bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound evaluation of anterior transvaginal mesh for pelvic organ prolapse: correlation to 5-year clinical outcomes
Authors: Poutakidis Georgios , Marsk Anna , Altman Daniel , Falconer Christian , Morcos Edward 
Published: June 2021

Abstract
Introduction and hypothesis
Vaginal prolapse mesh may effectively restore vaginal anatomy. The aim of this study was to investigate how the in vivo mesh position correlates to clinical outcomes.

Methods
Seventy-one women operated on using Uphold mesh for apical pelvic organ prolapse (POP-Q, C ≥ stage II) were examined 5 years after surgery by introital-perineal 2D ultrasound in a midsagittal plane at rest and Valsalva. The horizontal line and pubis symphysis were considered the reference for all measures. Ultrasound measures were statistically compared to clinical outcomes: POP-Q, Pelvic Floor Distress Inventory (PFDI-20) and subscales [Pelvic Organ Distress Inventory (PODI-6), and Urinary Distress Inventory (UDI-6)] and the VAS scale for pain.

Results
Original mesh length was preserved by 86% and correlated to improved pain as estimated by VAS scale (r 0.321). Valsalva was associated with a lowering of the superior and inferior mesh margins by 7.3 and 6.1 mm, respectively (p < 0.001) but a reduction of total mesh length by only 1 mm (30.2 ± 5.2 to 29.2 ± 4.7 mm, p < 0.001). Mobility of the anterior vaginal wall (bladder neck and midurethra) at Valsalva was parallel to downward movement of the mesh inferior margin (r 0.346 and 0.314) but inversely correlated to total UDI-6 (r − 0.254 and − 0.263). Mobility of the midurethra was inversely correlated to bladder emptying (PFDI-20 Question 19, r − 0.245).

Conclusions
Five years after surgery, preserved original length of the mesh with apical support was correlated to improved anatomical and patient-reported outcomes. Mesh support to the vaginal apex was associated with improved bladder emptying and total urinary distress outcomes but not stress urinary incontinence.
Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
Authors: Buchmueller Julia , Sprenger Heike , Ebmeyer Johanna , Rasinger Josef Daniel , Creutzenberg Otto , Schaudien Dirk , Hengstler Jan G. , Guenther Georgia , Braeuning Albert , Hessel-Pras Stefanie 
Published: June 2021

AbstractPyrrolizidine alkaloids (PAs) are secondary plant metabolites synthesized by a wide range of plants as protection against herbivores. These toxins are found worldwide and pose a threat to human health. PAs induce acute effects like hepatic sinusoidal obstruction syndrome and pulmonary arterial hypertension. Moreover, chronic exposure to low doses can induce cancer and liver cirrhosis in laboratory animals. The mechanisms causing hepatotoxicity have been investigated previously. However, toxic effects in the lung are less well understood, and especially data on the correlation effects with individual chemical structures of different PAs are lacking. The present study focuses on the identification of gene expression changes in vivo in rat lungs after exposure to six structurally different PAs (echimidine, heliotrine, lasiocarpine, senecionine, senkirkine, and platyphylline). Rats were treated by gavage with daily doses of 3.3 mg PA/kg bodyweight for 28 days and transcriptional changes in the lung and kidney were investigated by whole-genome microarray analysis. The results were compared with recently published data on gene regulation in the liver. Using bioinformatics data mining, we identified inflammatory responses as a predominant feature in rat lungs. By comparison, in liver, early molecular consequences to PAs were characterized by alterations in cell-cycle regulation and DNA damage response. Our results provide, for the first time, information about early molecular effects in lung tissue after subacute exposure to PAs, and demonstrates tissue-specificity of PA-induced molecular effects.
Hybrid mastopexy: improving outcomes on implant-based augmentation mastopexy with fat
Authors: Cuccia Giuseppe , Gagliardo Carola Maria , Romeo Marco , Di Trapani Benedetto 
Published: June 2021

Abstract
Background
Autologous fat transplantation for breast augmentation represents an increasingly interesting technique in plastic surgery. Only a few standardized procedures are available. Hybrid augmentation mastopexy combines the benefits of autologous fat transplantation and implant-based breast augmentation mastopexy, reducing implant-related complications and prothesis size. Herein, we describe our surgical approach as a “hybrid aesthetic surgery.”

Methods
A retrospective analysis of all patients who underwent hybrid breast augmentation and lifting with simultaneous fat grafting was carried out. Clinical outcomes, ultrasound evaluation of upper pole fullness, aesthetic postoperative results, and complications were examined.

Results
Eighteen patients with a mean age of 33 years (range: 24–52 years) and mean BMI of 25.8 kg/m2 (range: 21.4–32.1 kg/m2) were included in this study. Mean injected fat volume per breast was 115 cc (range: 78–144 cc). Patients were followed up for a mean of 9.4 months (range: 6–24 months). No fat necrosis or major complications were encountered during the follow-up. Patient satisfaction was high in terms of breast shape, size, and coverage of the breast implant. No recurrence of ptosis was observed yet and no secondary revision surgery was performed.

Conclusions
Hybrid mastopexy augmentation is an effective and safe procedure that combines the benefits of autologous fat grafting and implant-based breast augmentation. The transfer of autologous soft tissue allows obtaining a natural breast shape, reducing the onset of rippling and prothesis size. The reduction of prothesis size prevents ptosis recurrence but provides the desired projection. This reliable option improves long-term breast shape with elevated patient’s satisfaction.
Level of evidence: Level IV, therapeutic study.
Postoperative Pain Relief after Pancreatic Resection: Systematic Review and Meta‐Analysis of Analgesic Modalities
Authors: Akter Nasreen , Ratnayake Bathiya , Joh Daniel B. , Chan Sara‐Jane , Bonner Emily , Pandanaboyana Sanjay 
Published: June 2021

AbstractBackgroundThis systematic review explored the efficacy of different pain relief modalities used in the management of postoperative pain following pancreatoduodenectomy (PD) and distal pancreatectomy (DP) and impact on perioperative outcomes.MethodsMEDLINE (OVID), Embase, Pubmed, Web of Science and CENTRAL databases were searched using PRISMA framework. Primary outcomes included pain on postoperative day 2 and 4 and respiratory morbidity. Secondary outcomes included operation time, bile leak, delayed gastric emptying, postoperative pancreatic fistula, length of stay, and opioid use.ResultsFive randomized controlled trials and seven retrospective cohort studies (1313 patients) were included in the systematic review. Studies compared epidural analgesia (EDA) (n = 845), patient controlled analgesia (PCA) (n = 425) and transabdominal wound catheters (TAWC) (n = 43). EDA versus PCA following PD was compared in eight studies (1004 patients) in the quantitative meta‐analysis. Pain scores on day 2 (p = 0.19) and 4 (p = 0.18) and respiratory morbidity (p = 0.42) were comparable between EDA and PCA. Operative times, bile leak, delayed gastric emptying, pancreatic fistula, opioid use, and length of stay also were comparable between EDA and PCA. Pain scores and perioperative outcomes were comparable between EDA and PCA following DP and EDA and TAWC following PD.ConclusionsEDA, PCA and TAWC are the most frequently used analgesic modalities in pancreatic surgery. Pain relief and other perioperative outcomes are comparable between them. Further larger randomized controlled trials are warranted to explore the relative merits of each analgesic modality on postoperative outcomes with emphasis on postoperative complications.
Impact of intraepithelial capillary loops and atypical vessels in confocal laser endomicroscopy for the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma
Authors: Sievert Matti , Eckstein Markus , Mantsopoulos Konstantinos , Mueller Sarina K. , Stelzle Florian , Aubreville Marc , Oetter Nicolai , Maier Andreas , Iro Heinrich , Goncalves Miguel 
Published: June 2021

Abstract
Purpose
Confocal laser endomicroscopy (CLE) allows surface imaging of the laryngeal and pharyngeal mucosa in vivo at a thousand-fold magnification. This study aims to compare irregular blood vessels and intraepithelial capillary loops in healthy mucosa and squamous cell carcinoma (SCC) via CLE.

Materials and methods
We included ten patients with confirmed SCC and planned total laryngectomy in this study between March 2020 and February 2021. CLE images of these patients were collected and compared with the corresponding histology in hematoxylin and eosin staining. We analyzed the characteristic endomicroscopic patterns of blood vessels and intraepithelial capillary loops for the diagnosis of SCC.

Results
In a total of 54 sequences, we identified 243 blood vessels which were analyzed regarding structure, diameter, and Fluorescein leakage, confirming that irregular, corkscrew-like vessels (24.4% vs. 1.3%; P < .001), dilated intraepithelial capillary loops (90.8% vs. 28.7%; P < .001), and increased capillary leakage (40.7% vs. 2.5%; P < .001), are significantly more frequently detected in SCC compared to the healthy epithelium. We defined a vessel diameter of 30 μm in capillary loops as a cut-off value, obtaining a sensitivity, specificity, PPV, and NPV and accuracy of 90.6%, 71.3%, 57.4%, 94.7%, and 77.1%, respectively, for the detection of malignancy based solely on capillary architecture.

Conclusion
Capillaries within malignant lesions are fundamentally different from those in healthy mucosa regions. The capillary architecture is a significant feature aiding the identification of malignant mucosa areas during in-vivo, real-time CLE examination.
Mycobacterium chimaera: a report of 2 new cases and literature review
Authors: Natanti Alice , Palpacelli Marco , Valsecchi Marco , Tagliabracci Adriano , Pesaresi Mauro 
Published: June 2021

AbstractMycobacterium chimaera is a non-tuberculous mycobacterium, member of the Mycobacterium avium complex (MAC), which has become a global public health concern due to infection following cardiac surgery performed with contaminated heater-cooler units. M. chimaera infection is characterized by a long latency, non-specific signs and symptoms and high mortality rates. Thus, the diagnosis is still challenging both for forensic pathologists and for clinicians. Clinical manifestations of M. chimaera infection include endocarditis, hepatitis, nephritis, encephalitis and chorioretinitis. A constant histopathologic finding is the presence of non-caseating granulomas, with multinucleated giant cells and histiocytes. Hereby, we present two cases of fatal disseminated M. chimaera infection following aortic valve surgery reporting clinical history and post-mortem findings. Further, we provide a brief overview of the literature with a special focus on histopathological characteristics of M. chimaera infection. The aim of this article is to provide a complete synopsis of histopathological characteristics useful for forensic pathologists.
Serological response to SARS-CoV-2 vaccination in multiple sclerosis patients treated with fingolimod or ocrelizumab: an initial real-life experience
Authors: S. Guerrieri , S. Lazzarin , C. Zanetta , A. Nozzolillo , M. Filippi , L. Moiola 
Published: June 2021

Abstract
Background
Recent observations suggest a lack of humoral response after SARS-CoV-2 vaccination in multiple sclerosis (MS) patients treated with fingolimod or ocrelizumab

Objectives
To assess serological response to SARS-CoV-2 vaccination in MS patients receiving these disease-modifying treatments (DMTs) in a real-life setting.

Methods
Retrospective clinical data collection from MS patients followed at San Raffaele Hospital MS Centre (Milan, Italy). All patients treated with fingolimod or ocrelizumab who had received a complete anti-COVID-19 vaccination course, with no clinical history suggestive of previous SARS-CoV-2 infection and with an available post-vaccination serological assay obtained at least 14 days after vaccination completion were considered for the study.

Results
We collected data from 32 MS patients, 16 treated with fingolimod and 16 receiving ocrelizumab. Among the fingolimod group 10 patients (62.5%) had a positive serological response after vaccination and among ocrelizumab-treated patients a positive serological test was found in six cases (37.5%). No relation between serological response and clinical features (i.e., treatment duration, time between vaccination and last treatment dose, and white blood cells count) was identified.

Conclusions
Our initial real-life experience suggests a variable antibody production in MS patients receiving these DMTs. At present, there are no sufficient data to do not recommend anti-SARS-CoV-2 vaccine in these patients.
Sex dimorphism in dioecious Palmer amaranth (Amaranthus palmeri) in response to water stress
Authors: Mesgaran Mohsen B. , Matzrafi Maor , Ohadi Sara 
Published: June 2021

Abstract
Main conclusion
Phenological isolation can potentially reduce seed output and may be exploited as a novel tool for ecological management of dioecious weeds.

Abstract
Dioecious plants may benefit from a maximized outcrossing and optimal sex-specific resource allocation; however, this breeding system may also be exploited for weed management. Seed production in dioecious species is contingent upon the co-occurrence and co-flowering of the two genders and can be further disturbed by flowering asynchrony. We explored dimorphism in secondary sex characters in Amaranthus palmeri, and tested if reproductive synchrony can be affected by water stress. We have used seeds of A. palmeri from California, Kansas and Texas, and studied secondary sex characters under natural conditions and in response to water stress. Seeds of A. palmeri from California (CA) and Kansas (KS) were cordially provided by Dr. Anil Shrestha (California State University, Fresno, California) and Dr. Dallas E. Peterson (Kansas State University, Manhattan, Kansas), respectively. Seeds of a third population were collected from mature plants (about 30 plants) from a set-aside field in College Station, Texas. A. palmeri showed no sexual dimorphism with regard to the timing of emergence, plant height, and relative growth rate. While the initiation of flowering occurred earlier in males than females, females preceded males in timing of anthesis. Water stress delayed anthesis in males to a greater extent than females increasing the anthesis mismatch between the two sexes by seven days. Our data provide the first evidence of environment-controlled flowering asynchrony in A. palmeri. From a practical point of view, phenological isolation can potentially reduce seed output and may be exploited as a novel tool for ecological management of dioecious weeds.
Riesz transforms of a general Ornstein–Uhlenbeck semigroup
Authors: Casarino Valentina , Ciatti Paolo , Sjögren Peter 
Published: June 2021

AbstractWe consider Riesz transforms of any order associated to an Ornstein–Uhlenbeck operator with covariance given by a real, symmetric and positive definite matrix, and with drift given by a real matrix whose eigenvalues have negative real parts. In this general Gaussian context, we prove that a Riesz transform is of weak type (1, 1) with respect to the invariant measure if and only if its order is at most 2.
Conservation laws for even order systems of polyharmonic map type
Authors: de Longueville Frédéric Louis , Gastel Andreas 
Published: June 2021

AbstractFollowing Rivière’s study of conservation laws for second order quasilinear systems with critical nonlinearity and Lamm/Rivière’s generalization to fourth order, we consider similar systems of order 2m. Typical examples are m-polyharmonic maps. Under natural conditions, we find a conservation law for weak solutions on 2m-dimensional domains. This implies continuity of weak solutions.
Isolated singularities for the n-Liouville equation
Authors: Esposito Pierpaolo 
Published: June 2021

AbstractIn dimension n isolated singularities—at a finite point or at infinity—for solutions of finite total mass to the n-Liouville equation are of logarithmic type. As a consequence, we simplify the classification argument in Esposito (Anal Non Linéaire 35(3):781–801, 2018) and establish a quantization result for entire solutions of the singular n-Liouville equation.
Several results on compact metrizable spaces in $$\mathbf {ZF}$$
Authors: Keremedis Kyriakos , Tachtsis Eleftherios , Wajch Eliza 
Published: June 2021

AbstractIn the absence of the axiom of choice, the set-theoretic status of many natural statements about metrizable compact spaces is investigated. Some of the statements are provable in $$\mathbf {ZF}$$
ZF
, some are shown to be independent of $$\mathbf {ZF}$$
ZF
. For independence results, distinct models of $$\mathbf {ZF}$$
ZF
and permutation models of $$\mathbf {ZFA}$$
ZFA
with transfer theorems of Pincus are applied. New symmetric models of $$\mathbf {ZF}$$
ZF
are constructed in each of which the power set of $$\mathbb {R}$$
R
is well-orderable, the Continuum Hypothesis is satisfied but a denumerable family of non-empty finite sets can fail to have a choice function, and a compact metrizable space need not be embeddable into the Tychonoff cube $$[0, 1]^{\mathbb {R}}$$

[
0
,
1
]

R

.
20 years on: the legacy of Daksha Emson for perinatal psychiatry
Authors: Casanova Dias Marisa , Sönmez Güngör Ekin , Dolman Clare , De Picker Livia , Jones Ian 
Published: June 2021

AbstractThe tragedy of Daksha’s death illustrates both the importance of perinatal mental health and the stigma associated with doctors seeking help. With this letter, we express our hope that the lasting legacy of her and others’ tragic stories lies in the continuing improvement and worldwide expansion of perinatal psychiatric services and training so that those in greatest need receive the best care possible wherever — and whoever — they are.
Cyclic tensile strain affects the response of human periodontal ligament stromal cells to tumor necrosis factor-α
Authors: Zhao Zhongqi , Behm Christian , Rausch Marco Aoqi , Tian Zhiwei , Rausch-Fan Xiaohui , Andrukhov Oleh 
Published: June 2021

AbstractObjectivesOrthodontic treatment in adult patients predisposed to mild or severe periodontal disease is challenging for orthodontists. Orthodontic malpractice or hyper-occlusal forces may aggravate periodontitis-induced destruction of periodontal tissues, but the specific mechanism remains unknown. In the present study, the combined effect of mechanical stress and tumor necrosis factor (TNF)-α on the inflammatory response in human periodontal ligament stromal cells (hPDLSCs) was investigated.Materials and methodshPDLSCs from 5 healthy donors were treated with TNF-α and/or subjected to cyclic tensile strain (CTS) of 6% or 12% elongation with 0.1 Hz for 6- and 24 h. The gene expression of interleukin (IL)-6, IL-8 and cell adhesion molecules VCAM and ICAM was analyzed by qPCR. The protein levels of IL-6 and IL-8 in conditioned media was measured by ELISA. The surface expression of VCAM-1 and ICAM-1 was quantified by immunostaining followed by flow cytometry analysis.ResultsTNF-α-induced IL-6 gene and protein expression was inhibited by CTS, whereas TNF-α-induced IL-8 expression was decreased at mRNA expression level but enhanced at the protein level in a magnitude-dependent manner. CTS downregulated the gene expression of VCAM-1 and ICAM-1 under TNF-α stimulation, but the downregulation of the surface expression analyzed by flow cytometry was observed chiefly for VCAM-1.ConclusionsOur findings show that mechanical force differentially regulates TNF-α-induced expression of inflammatory mediators and adhesion molecules at the early stage of force application. The effect of cyclic tensile strain is complex and could be either anti-inflammatory or pro-inflammatory depending on the type of pro-inflammatory mediators and force magnitude.Clinical relevanceOrthodontic forces regulate the inflammatory mediators of periodontitis. The underlying mechanism may have significant implications for future strategies of combined periodontal and orthodontic treatment.
Soft robotics: the route to true robotic organisms
Authors: Rossiter Jonathan 
Published: June 2021

AbstractSoft Robotics has come to the fore in the last decade as a new way of conceptualising, designing and fabricating robots. Soft materials empower robots with locomotion, manipulation, and adaptability capabilities beyond those possible with conventional rigid robots. Soft robots can also be made from biological, biocompatible and biodegradable materials. This offers the tantalising possibility of bridging the gap between robots and organisms. Here, we discuss the properties of soft materials and soft systems that make them so attractive for future robots. In doing so, we consider how future robots can behave like, and have abilities akin to, biological organisms. These include huge numbers, finite lifetime, homeostasis and minimal—and even positive—environmental impact. This paves the way for future robots, not as machines, but as robotic organisms.
The Frontal Assessment Battery (FAB) and its sub-scales: validation and updated normative data in an Italian population sample
Authors: Aiello Edoardo Nicolò , Esposito Antonella , Gramegna Chiara , Gazzaniga Valentina , Zago Stefano , Difonzo Teresa , Appollonio Ildebrando Marco , Bolognini Nadia 
Published: June 2021

Abstract
Background
Deficits of executive functioning (EF) are frequently found in neurological disorders. The Frontal Assessment Battery (FAB) is one of the most widespread and psychometrically robust EF screeners in clinical settings. However, in Italy, FAB norms date back to 15 years ago; moreover, its validity against “EF-loaded” global cognitive screeners (e.g., the Montreal Cognitive Assessment, MoCA) has yet to be tested. This study thus aimed at (a) providing updated normative data for the Italian FAB and (b) assessing its convergent validity with the MoCA.

Methods
Four-hundred and seventy-five healthy Italian native speakers (306 females, 169 males; mean age: 61.08 ± 15.1; mean education: 11.67 ± 4.57) were administered by the MoCA and the FAB. FAB items were divided into three subscales: FAB-1 (linguistically mediated EF), FAB-2 (planning), and FAB-3 (inhibition). Regression-based norms were derived (equivalent scores) for all FAB measures.

Results
Age and education were predictive of all FAB measures, whereas no gender differences were detected. The FAB and its sub-scales were related to MoCA measures—the strongest associations being found with MoCA total and MoCA-EF scores. FAB sub-scales were both internally related and associated with FAB total scores.

Discussion
The FAB proved to have convergent validity with both global cognitive and EF measures in healthy individuals. The present study provides updated normative data for the FAB and its sub-scales in an Italian population sample, and thus supports an adaptive usage of this EF screener.