bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Disease and Breast Cancer Stage at Diagnosis
Authors: Angelov Ivan , Haas Allen M. , Brock Elizabeth , Luo Lingfeng , Zhao Jing , Smith Benjamin D. , Giordano Sharon H. , Leeper Nicholas J. , Nead Kevin T. 
Published: January 2025

ImportanceCardiovascular disease (CVD) and cancer are the leading causes of mortality in the US. Large-scale population-based and mechanistic studies support a direct effect of CVD on accelerated tumor growth and spread, specifically in breast cancer.ObjectiveTo assess whether individuals presenting with advanced breast cancers are more likely to have prevalent CVD compared with those with early-stage breast cancers at the time of diagnosis.Design, Setting, and ParticipantsThis population-based case-control study used data from the Surveillance, Epidemiology, and End Results–Medicare linked databases from 2009 to 2020. The analysis was completed from May 2023 to August 2024. Participants were female patients aged at least 66 years diagnosed with invasive breast cancer. Cases were matched with controls by breast cancer stage at diagnosis and propensity scores using factors known to be associated with delayed cancer diagnosis.ExposurePrevalent CVD prior to breast cancer diagnosis.Main Outcomes and MeasuresThe outcome of interest was the odds of locally advanced (T3-4 or N+) or metastatic (M+) breast cancer status at diagnosis.ResultsThe full analytic cohort included 19 292 matched individuals, with median (IQR) age 73 (70-79) years, of whom 1676 (8.7%) were Black and 16 681 (86.5%) were White; 9478 individuals (49.1%) had prevalent CVD. Propensity score–matched, multivariable-adjusted models found that individuals with locally advanced or metastatic breast cancer at diagnosis had statistically significantly increased odds of prevalent CVD (odds ratio [OR], 1.10; 95% CI, 1.03-1.17; P = .007). This association was observed among hormone receptor–positive (OR, 1.11; 95% CI, 1.03-1.19; P = .006) but not hormone receptor–negative (OR, 1.02; 95% CI, 0.86-1.21; P = .83) breast cancer. ORs were directionally consistent when separately examining locally advanced (OR, 1.09; 95% CI, 1.02-1.17; P = .02) and metastatic (OR, 1.20; 95% CI, 0.94-1.54; P = .15) disease, among all receptor subtypes.Conclusions and RelevanceThis case-control study found that individuals with more advanced breast cancer at diagnosis were more likely to have prevalent CVD. This finding may be specific to hormone receptor–positive and ERBB2-negative (formerly HER2) disease. Future studies are needed to confirm these findings and investigate interventions to improve patient outcomes, including personalized cancer screening.
Social Determinants of Health and Suicide-Related Outcomes
Authors: Na Peter Jongho , Shin Jeonghyun , Kwak Ha Rim , Lee Jaewon , Jester Dylan J. , Bandara Piumee , Kim Jim Yong , Moutier Christine Y. , Pietrzak Robert H. , Oquendo Maria A. , Jeste Dilip V. 
Published: January 2025

ImportancePreventing suicide is one of the top priorities in public health policy. Identifying key social determinants of health (SDOH) in suicide risk is critical for informing clinical practices, future research, and policy solutions to prevent suicide.ObjectiveTo examine the associations of SDOH with suicide-related outcomes.Data SourcesStudies published before July 2023 were searched through PubMed, PsycINFO, Embase, and Web of Science. The date of the search was August 4, 2023.Study SelectionWe included the most up-to-date meta-analyses reporting associations between SDOH and suicide-related outcomes.Data Extraction and SynthesisThree independent reviewers extracted data and conducted quality assessment using the Joanna Briggs Institute Checklist for Systematic Reviews and Research Syntheses.Main Outcomes and MeasuresThe main outcomes of interest were suicide mortality, suicide attempt, and suicidal ideation.ResultsA total of 46 meta-analyses met inclusion criteria. For suicide mortality, justice system–involved individuals in the community, exposure to others’ and parental suicide, firearm accessibility, divorce, experience in foster care, release from incarceration, and midlife (age 35-65 years) unemployment were the SDOH with consistently strong effects. Individuals released from incarceration demonstrated a high prevalence of suicide mortality (114.5 per 100 000 persons). With regard to suicide attempt, experience of childhood abuse and maltreatment and sexual assault, gender and sexual minority status, and parental suicide mortality were the strongest risk factors. The prevalence of suicide attempt among homeless individuals (28.9%; 95% CI, 21.7%-37.2%) and incarcerated female youths (27%; 95% CI, 20%-34%) and adults (12.2%; 95% CI, 7.1%-17.2%) was high. For suicidal ideation, identification as bisexual and intimate partner violence in women were the strongest risk factors. The prevalence of lifetime suicidal ideation in homeless individuals was 41.6% (95% CI, 28.6%-56.0%). Protective factors associated with reduced risk of suicide mortality were religious affiliation and being married. School connectedness showed protective associations against suicide attempt and suicidal ideation.Conclusions and RelevanceTailoring interventions and future research for identified priority subpopulations, such as justice system–involved individuals in the community, and implementing policy measures addressing the SDOH that showed strong associations with suicide mortality, attempts, and ideation, such as gun licensing requirements, are critical to counteracting social and environmental forces that increase suicide risk.
3D Shape Control of Printed Micro‐Electrodes with Substrate Reshaping
Authors: Martí‐Jerez E. , Fernández‐Pradas J. Marcos , Serra P. , Duocastella M. 
Published: December 2024

AbstractAdditive manufacturing (AM) techniques based on liquid precursors, including inkjet printing or laser‐induced forward transfer (LIFT), are emerging as the tool‐of‐choice for the on‐demand fabrication of printed electronic devices on flat and flexible substrates. However, the aspect ratio of the printable structures, which is key for determining electrical properties, is typically determined by the wettability between printed ink and substrate. Higher aspect‐ratio structures can only be achieved by multi‐pass printing, with the consequent loss of fabrication throughput and increase in complexity. Here, these issues are addressed by using print‐n‐release, a method based on printing micro‐electrodes on pre‐stretched elastomeric substrates. Upon stress release, the liquid‐printed electrodes shrink while increasing their aspect‐ratio. As a result, their final shape can be tailored beyond the limitations imposed by wetting constraints, enabling intentional miniaturization by design. The principle and practical implementation of print‐n‐release are described, and show how electrodes with up to an 8 fold increase in aspect‐ratio and a 4 fold reduction in sheet resistance can be produced in a single‐pass compared to traditional printing methods. As a proof‐of‐concept, functional interdigitated electrodes that serve as sensors for drop volume and electrolyte concentration, delivering enhanced sensitivity and a reduced footprint not achievable with standard printing techniques are fabricated.
CMOS‐Compatible HfOx‐Based Radiation Hardening Component for Neuromorphic Computing Applications
Authors: Chang Yao‐Feng , Huang Yifu , Chung Chin‐Han , Chen Ying‐Chen 
Published: January 2025

AbstractHfOx‐based resistive random‐access‐memory (ReRAM) devices (TiN/Ti/HfOx/RuOx/TiN) are fabricated by CMOS‐compatible materials (ruthenium (Ru)) and lithography‐lite process, potentially enabling a maskless, etching‐free process that can be implemented in the low earth orbit (LEO), the International Space Station (ISS), and commercial LEO destinations (CLDs). The devices met the requirements for qualified manufacturers list verification (QMLV) and radiation hardness assurance (QMLV‐RHA), as well as Advanced Next Generation Strategic Radiation, hardened Memory (ANGSTRM), which potentially support LEO, medium earth orbit, and geosynchronous orbit missions. Specifically, after a 5‐Mrad total ionizing dose (TID) test, the electrical characterized results showed non‐degradation performance, memory window ≈40 with operation power < mW, capability of > 000‐times endurance and 15‐year retention. The Ruthenium oxide (RuOx) can serve as a photon‐absorb sink to reduce the switching layer damage caused by heating induced by radiation, supported by Particle and Heavy Ion Transport Code System Monte Carlo simulation. Furthermore, the neural network by HfOx/RuOx‐based ReRAM device is trained with the inference accuracy at various TIDs for a potential neuromorphic hardware system demonstration. The results show that HfOx/RuOx‐based ReRAM neuromorphic computing is quite robust as a radiation‐hardened structure, providing a development path to realize programmable computing chip tolerance under irradiation.
Application and residual effects of poultry litter biochar on cropping system yields
Authors: Freitas A. M. , Nair V. D. , Sollenberger L. E. , Harris W. G. , Rodriguez A. N. 
Published: December 2024

AbstractAnimal manures such as poultry litter supply plant‐available phosphorus (P), but P loss can occur following manure application to crops, particularly in sandy soils. The transformation of poultry litter biochar (PLB) reduces P losses upon application to crops while providing essential plant nutrients. Our objectives were to evaluate: (1) the effects of PLB on crop yields when applied at the same total P rate as inorganic P fertilizer and (2) the residual effect of previous‐year PLB and inorganic P fertilization on crop yield at two locations with different soil types (Entisols and Spodosols). Inorganic P, PLB, and no‐P treatments were allocated to six replicates of a randomized complete block design at each location. The cropping system was sequential plantings of rye, corn, and sorghum each year for 2 years. The residual effect of P application was quantified in Year 2 when first‐year PLB and inorganic P plots were subdivided, with half receiving no additional P and half receiving the same P application as the previous year. After each crop was harvested, crop yield, nitrogen (N) and P levels in plant tissue, and the soil phosphorus storage capacity were determined. PLB supported either similar or significantly greater cumulative biomass yields compared with inorganic P fertilization at the two locations. The effect of residual PLB on yield varied with the location and crop, highlighting the importance of soil type and management practices in optimizing the benefits of this amendment.
Quinoa productivity and quality under irrigated conditions through crop establishment methods in Pakistan
Authors: Hanif Muhammad Kashif , Afzal Irfan 
Published: December 2024

AbstractQuinoa (Chenopodium quinoa Willd.) is gaining global recognition for its nutritional benefits and adaptability to various environments. However, there is limited data on how different planting methods affect the productivity and quality of quinoa genotypes with varying panicle shapes, especially under irrigated conditions. We hypothesized that different crop establishment techniques influence the performance of quinoa genotypes in terms of phenology, weeds, growth, and yield aiming to enhance both yield and grain quality. To test this, a 2‐year field experiment (2021–2022 and 2022–2023) was conducted at Ayub Agricultural Research Institute, Faisalabad, Pakistan. The experiment used split‐plot design with three replications incorporating three sowing methods in main plots: ridge sowing (RS), line sowing (LS), and broadcasting (BC) and three quinoa genotypes with different panicle architectures: UAF‐Q7 (intermediate), Line‐105 (glomerulate), and Line‐22 (amarantiform) in subplots. Results indicated that LS method improved morphological and yield attributes like stem thickness, terminal panicle length and weight, grain yield, 1000‐grain weight, and biological yield compared to RS and BC. Among genotypes, Line‐105 showed superior performance in morphology, biomass, and yield, while UAF‐Q7 had higher grain protein content. Panicle number per plant showed positive correlation with terminal panicle weight, grain yield, 1000‐grain weight, and harvest index. LS also resulted in highest crop growth rate and grain quality. The study suggests that LS is a better planting technique and Line‐105 is a suitable genotype for achieving high grain yield under irrigated conditions.
Navigating Liminality in Evolving Forensic Anthropology Professionalism
Authors: Boyd Donna C. 
Published: December 2024

ABSTRACTEmerging aspects of professionalism within forensic anthropology, while enhancing the scientific foundation and practice for the discipline, have created liminalistic spaces and experiences in education and training, employment, ethics, and identities that reflect the broader transitional status in the discipline as a whole. These liminal states and problems are discussed in terms of their creation, development, and potential for resolution. They are interpreted within a liminal framework which requires navigation through significant changes in roles, status, and identity in forensic anthropology practice. Recommendations for mitigating the identified deficiencies, ambiguities, and frustrations they produce include expansion of educational training, certification, employment options, and roles and responsibilities, as well as adherence to standards and recognition and promotion of self‐care. Successful navigation of these issues will lead to a stronger future for both the discipline and the practitioner.
Disrupted brain networks underlying high‐fidelity memory retrieval in subjective cognitive decline: A task‐based fMRI study
Authors: Tang Wei , Zeng Qinghe , Xie Kaiqi , Cui Xiaoyu , Jin Xinhu , Han Ying , Li Juan 
Published: December 2024

AbstractINTRODUCTIONSubjective cognitive decline (SCD) is linked to memory complaints and disruptions in certain brain regions identified by molecular imaging and resting‐state functional magnetic resonance imaging studies. However, it remains unclear how these regions interact to contribute to both subjective and potential objective memory issues in SCD.METHODSTo address this gap, task‐based imaging studies are essential. The Mnemonic Similarity Task assessed high‐fidelity retrieval meanwhile MRI data measured group differences in activation and functional connectivity (FC) (calculated by generalized psychophysiological Interaction) between SCD individuals and normal controls.RESULTSWorse high‐fidelity retrieval in SCD was associated with hypoactivation in the hippocampus, hyperactivation in the control network (CN), and reduced FC between the hippocampus and CN. The angular gyrus (AG) partially drives this disconnection.DISCUSSIONThis study confirms objective cognitive deficits in SCD and highlights the AG's failure to integrate, addressing a gap in the literature that has primarily focused on the hippocampus and CN.Highlights
Objective high‐fidelity retrieval deficits detected in older adults with SCD.
Dysfunctional neural activations within retrieval networks impair memory accuracy.
Reduced task‐based FC drives high‐fidelity retrieval deficits.
The SCD‐related disruption of integrative function partly explains such deficits.
Future studies may benefit from inspections on obstruction in cognitive process.
Highly Sensitive LC–MS/MS Method for Determination of Dexamethasone in Rat Plasma and Brain Tissue: An Application to Pharmacokinetic Study in Rats
Authors: Bestha Rama Murthi , Zakkula Ashok , Keerthana Madipelli , Kaddare Sandeep , Veerla Niranjan , Mullangi Ramesh , Dittakavi Sreekanth 
Published: December 2024

ABSTRACTA highly sensitive and rapid LC–MS/MS method was developed and validated for the quantification of dexamethasone in rat plasma and brain tissue. Protein precipitation method was used for sample preparation. The separation of dexamethasone and the IS (labetalol) was achieved on an Atlantis dC18 column using an isocratic mobile phase (10 mM ammonium formate and acetonitrile, 25/75, v/v) delivered at 0.7 mL/min flow‐rate. Dexamethasone and the IS were eluted at 1.03 and 1.06 min, respectively. The MS/MS transitions monitored were m/z 393.100 → 373.100 (dexamethasone) and 329.100 → 91.100 (IS). Method validation was performed as per FDA guidelines and all parameters met the acceptance criteria. The assay was validated with a quantification range of 0.05–1046 ng/mL in both matrices. The intraday and interday precision for were in the range of 2.62–7.28 and 2.76%–6.98% and 2.24–6.85 and 2.97%–6.37%, in plasma and brain tissue, respectively. Dexamethasone was stable in a series of stability conditions in both matrices. Post‐intravenous administration to rats, dexamethasone concentrations in plasma and brain tissue were quantifiable up to 24 and 10 h, respectively. Dexamethasone half‐life was ~2.30 h. Dexamethasone exhibited low clearance and moderate volume of distribution in plasma but in brain tissue the clearance and volume of distribution were high.
Dynamic Metabolic Characterization of Lung Tissues in Rats Exposed to Whole‐Thorax Irradiation Based on GC‐MS
Authors: Wang WenLi , Gu Liming , Hong Xiedong , Gao Zhipiao , Liu Shanghai , Ren Yifan , Wang Yun , Tian Lang , Wang Chang 
Published: December 2024

ABSTRACTAn animal model of radiation‐induced lung injury (RILI) was established using female rats given sublethal whole‐thorax X‐ray irradiation (15 Gy) at a dose rate of 2.7 Gy/min. The rats were studied for up to day 45 and compared with sham‐irradiated controls. Time‐series lung tissue samples during the progression of RILI were collected for dynamic metabolomics studies based on gas chromatography–mass spectrometry (GC‐MS). Differential metabolites associated with radiation‐induced lung injury were identified, followed by metabolite set enrichment analysis to uncover pathway changes in RILI. The results revealed dynamic metabolic alterations in the progression of RILI, primarily involving in glycine and serine metabolism, the urea cycle, the Warburg effect, glutamate metabolism, arginine and proline metabolism, glucose‐alanine cycle, and ammonia recycling. In addition, the potential panel of biomarkers including taurine, lysine, and tyrosine of RILI was selected and then applied to evaluate the diagnostic potential for RILI based on the receiving operator characteristic curve (ROC) at the early‐stage of RILI. The better sensitivity, specificity, and accuracy indicate the potential of early diagnosis for RILI. These findings suggest that dynamic metabolomics data could provide new insights into understanding the complex metabolic dysregulation underlying RILI, facilitating the selection of biomarkers for early diagnosis.
Simultaneous Determination of Vitamins A and E and Their Generated Metabolites in Human Serum by LC–MS/MS
Authors: Jia Yongjuan , Liu Xingli , Liu Chunran , Chen Yongmei , Li Wei 
Published: December 2024

ABSTRACTIn the context of personalized and precision medicine, simultaneous monitoring of different forms of vitamins A and E and their metabolites could help us better understand the status of vitamins A and E in the body. The aim of this study was to establish a method for simultaneous determination of 13 kinds of vitamins A and E and their metabolites in human serum. Serum samples were directly detected by LC–MS/MS after deproteinization. Chromatographic and mass spectrometry parameters were optimized to achieve good separation and sensitivity for these analytes, especially for isomers. Finally, all analytes were effectively separated on Kinetex biphenyl stationary phase. The method covered a large profile of vitamins A and E and their metabolites in a run time only of 10 min. Good linearities were achieved in the quantitative range for each analyte with the correlation coefficients higher than 0.9916. The recoveries were in the range of 78.8%–111.6% with the intraday and interday precisions within 9.6%. This method was simple, sensitive, and accurate and had been successfully applied for the determination of vitamins A and E and their metabolites in human serum samples and could provide technical support for clinical nutritional evaluation of these vitamins.
Mainshock–aftershock seismic fragility assessment of civil structures: A state‐of‐the‐art review
Authors: Rashid Muhammad , Nishio Mayuko 
Published: December 2024

AbstractSequential seismic events occur worldwide, which impose significant threats to the safety and serviceability of Civil infrastructure, especially buildings and bridges. Fragility functions are imperative to support decision‐making tools for potential seismic risk identification and its impact on structural performance during sequential earthquakes. The increasing number of publications shows a notable increase in interest among researchers and the scientific community in this domain. This study presents a systematic review of available resources and techniques for structural performance and fragility evaluation subjected to mainshock–aftershock seismic loading. Efforts have been made to focus on the salient features of various approaches rather than criticizing the mathematical frameworks and associated analysis approaches. Existing knowledge related to the effect of sequential seismic loading on buildings and bridge infrastructures and their fragility estimates is presented concisely. The paper concludes by detailing the opportunities for future developments in the fragility analysis of Civil infrastructure under sequential seismic hazard. This would encourage stakeholders and decision‐makers to put into practice their applications for risk mitigation, recovery planning, and well‐informed decision‐making.
Mixed Convective and Nonuniform Internal Heat Generation Effect on Hydromagnetic Micropolar Fluid Flowing Across a Permeable Stretchy Wall: A Numerical Investigation
Authors: Oderinu R. A. , Ayanbukola F. J. , Alao S. , Sanusi B. A. , Oyeyinka T. A. 
Published: January 2025

ABSTRACTThe quest to efficiently manage heat generation/absorption in industries, such as chemical production, mechanical machines, oil exploration, and aeronautical engineering, is in high demand. This study is conducted to examine the impacts of internal heat generation/absorption as well as unsteady mixed convection of the micropolar fluid through a permeable channel. The formulated nonlinear fundamental equations converted from partial differential equation to ordinary differential equation are numerically analyzed and solved using the Laguerre Collocation Method along with Gauss–Lobatto points. To verify the simulation's accuracy, validation is performed via shooting technique with the fourth‐order Runge–Kutta method acting as the control method with the aid of Mathematica 11.0 software. The behavior of the flow was influenced by various physical parameters, which were analyzed using plots and tables. Impacts of skin friction, Sherwood number, and Nusselt number are evaluated. The findings reveal that an improvement in the micropolar term leads to an enhancement in temperature and velocity while angular momentum declines. Additionally, it was revealed that an increase in nonuniform heat generation parameters, magnetic term, and Eckert number improves the temperature profile, while the greater Grashof number results in an enhancement in the velocity profile.