bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genotypic and phenotypic prevalence of Nocardia species in Iran: First systematic review and meta-analysis of data accumulated over years 1992-2021
Authors: Hashemzadeh Mohammad , Dezfuli Aram Asareh Zadegan , Khosravi Azar Dokht , Savari Mohammad , Jahangirimehr Fatemeh 
Published: July 2021

Background
Nocardia species belong to the aerobic actinomycetes group of bacteria which are gram-positive and partially acid-fast Bacilli. These bacteria may sometimes be associated with nosocomial infections. Nocardia diseases are not required to be reported to public health authorities in Iran. Hence, the present study was designed to determine the prevalence of human Nocardia spp. in Iran by using a systematic review and meta-analysis according to the preferred reporting items for systematic reviews and meta-Analyses statement.

Methods
The data of the prevalence of Nocardia species were collected from databases such as Embase, PubMed/MEDLINE via Ovid, Web of Science, Scopus and Google Scholar as well as national Iranian databases, including SID, Magiran. Analyses were conducted by STATA 14.0.

Results
The meta-analyses showed that the proportion of Nocardia spp. in Iranian studies varied from 1.71(1.17, 2.24) to 0.46(0.09, 0.83). N. asteroides (21% [95% CI 1.17, 2.24]), N. cyriacigeorgica (17% [95% CI 0.99, 1.77]), N. facanica (10% [95% CI 0.75, 1.00]) were considered to be common causative agents.

Conclusions
Our study presents that despite the fact that Nocardia spp. are normally are saprophytic organisms, are currently accounts as emerging pathogens due to an increase in immunocompromised patients among Iranian populations. Considering our results, the establishment of advanced diagnostic facilities for the rapid detection of Nocardia infections are required for optimal therapeutic strategies of Nocardia spp. in Iran. Our findings could help the programmatic management of the disease within the context of Nocardia control programs.
12 weeks of strength training improves fluid cognition in older adults: A nonrandomized pilot trial
Authors: Macaulay Timothy R. , Pa Judy , Kutch Jason J. , Lane Christianne J. , Duncan Dominique , Yan Lirong , Schroeder E. Todd 
Published: July 2021

Objectives
Resistance training (RT) is a promising strategy to slow or prevent fluid cognitive decline during aging. However, the effects of strength-specific RT programs have received little attention. The purpose of this single-group proof of concept clinical trial was to determine whether a 12-week strength training (ST) program could improve fluid cognition in healthy older adults 60 to 80 years of age, and to explore concomitant physiological and psychological changes.

Methods
Twenty participants (69.1 ± 5.8 years, 14 women) completed this study with no drop-outs or severe adverse events. Baseline assessments were completed before an initial 12-week control period, then participants were re-tested at pre-intervention and after the 12-week ST intervention. The NIH Toolbox Cognition Battery and standard physical and psychological measures were administered at all three time points. During the 36 sessions of periodized ST (3 sessions per week), participants were supervised by an exercise specialist and challenged via autoregulatory load progression.

Results
Test-retest reliability over the control period was good for fluid cognition and excellent for crystallized cognition. Fluid composite scores significantly increased from pre- to post-intervention (8.2 ± 6.1%, p < 0.01, d = 1.27), while crystallized composite scores did not (-0.5 ± 2.8%, p = 0.46, d = -0.34). Performance on individual fluid instruments, including executive function, attention, working memory, and processing speed, also significantly improved. Surprisingly, changes in fluid composite scores had small negative correlations with changes in muscular strength and sleep quality, but a small positive correlation with changes in muscular power.

Conclusions
Thus, improvements in fluid cognition can be safely achieved in older adults using a 12-week high-intensity ST program, but further controlled studies are needed to confirm these findings. Furthermore, the relationship with other widespread physiological and psychological benefits remains unclear.
Time-trends and predictors of interhospital transfers and 30-day rehospitalizations after acute coronary syndrome from 2000-2015
Authors: Rocha J. Afonso , Cardoso José Carlos , Freitas Alberto , Allison Thomas G. , Azevedo Luís F. 
Published: July 2021

AimsAssess trends and factors associated with interhospital transfers (IHT) and 30-day acute coronary syndrome (ACS) rehospitalizations in a national administrative database of patients admitted with an ACS between 2000–2015.Methods and resultsCohort study of patients hospitalized with ACS from 2000 to 2015, using a validated linkage algorithm to identify and link patient-level sequential hospitalizations occurring within 30 days from first admission (considering all hospitalizations within the 30-day timeframe as belonging to the same ACS episode of care-ACS-EC). From 212,481 ACS-EC, 42,670 (20.1%) had more than one hospitalization. ACS-EC hospitalization rates decreased throughout the study period (2000: 207.7/100.000 person-years to 2015: 185,8/100,000 person-years, p for trend <0.05). Proportion of IHT increased from 10.5% in 2000 to 20.1% in 2015 compared to a reduction in both planned and unplanned 30-day ACS rehospitalization from 9.0% in 2000 to 2.7% in 2015. After adjusting for patient and first admission hospital’s characteristics, compared to 2000–2003, in 2012–2015 the odds of IHT increased by 3.81 (95%CI: 3.65–3.98); the odds of unplanned and planned 30-day ACS rehospitalization decreased by 0.36 (95%CI: 0.33; 0.39) and 0.47 (95%CI: 0.43; 0.53), respectively. Female sex, older age and the presence and severity of comorbidities were associated with lower likelihood of being transferred or having a planned 30-day ACS rehospitalization. Unplanned 30-day ACS rehospitalization was more likely in patients with higher comorbidity burden.ConclusionIHT and 30-day ACS rehospitalization reflect coronary referral network efficiency and access to specialized treatment. Identifying factors associated with higher likelihood of IHT and 30-day ACS rehospitalization may allow heightened surveillance and interventions to reduce rehospitalizations and inequities in access to specialized treatment.
Media Game Edukasi Quizizz dalam Pembelajaran Sejarah Kebudayaan Islam Sebagai Upaya Meningkatkan Hasil Belajar Siswa
Authors: Amaliyatul Ulya  , Ahmad Arifi  
Published: July 2021

History of Islamic Culture (SKI) is a subject that emphasizes the ability of students to take lessons from Islamic history by imitating figures who excel in their time and developing Islamic culture and civilization. The purpose of this study was to determine the effectiveness of the Quizizz Educational Game in improving student learning outcomes in SKI lessons at MI Al-Huda. This research is a type of field research with an experimental approach. The research subjects were class 4 students, totaling 52 students. Class IVA became the experimental class with 25 students and class IVB became the control class with 27 students. Methods of data collection using tests, interviews, observation, and documentation. The results showed that learning with the Quizizz Educational Game in class IVA was effective. The test results showed an increase in student learning outcomes in the experimental class compared to the control class. The average score increase in the experimental class was 9.83 and for the control class, it increased by 9.6. Based on statistical analysis with the t-test calculation, the significance value was 0.000 <0.05. The results of the statistical test indicate that there is a significant difference in the learning outcomes of SKI between the experimental group and the control group. This proves that the increase in student learning outcomes is influenced by the use of Quizizz Educational Games.
Abstrak: Sejarah Kebudayaan Islam (SKI) merupakan mata pelajaran yang menekankan pada kemampuan peserta didik dalam mengambil hikmah pelajaran dari sejarah Islam dengan cara meneladani tokoh yang berprestasi pada masanya serta mengembangkan kebudayaan serta peradaban Islam. Tujuan penelitian ini untuk mengetahui efektivitas Game Edukasi Quizizz dalam meningkatkan hasil belajar siswa pada pelajaran SKI di MI Al-Huda. Penelitian ini termasuk jenis penelitian lapangan dengan pendekatan eksperimen. Subjek penelitianya adalah peserta didik kelas 4 yang berjumlah 52 siswa. Kelas IVA menjadi kelas eksperimen berjumlah 25 siswa dan kelas IVB menjadi kelas kontrol dengan jumlah 27 siswa. Metode pengumpulan data menggunakan tes, wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa pembelajaran dengan Game Edukasi Quizizz di kelas IVA berjalan efektif. Hasil tes memperlihatkan adanya peningkatan hasil belajar peserta didik di kelas eksperimen dibanding kelas kontrol. Rata-rata peningkatan nilai di kelas eskperimen sebesar 9,83 dan untuk kelas kontrol meningkat sebesar 9,6. Berdasarkan analisis statistik dengan perhitungan uji-t didapatkan nilai signifikansinya 0,000 < 0,05. Hasil uji statistik tersebut menunjukkan bahwa adanya perbedaan yang signifikan hasil belajar SKI antara kelompok eksperimen dan kelompok kontrol. Hal ini membuktikan bahwa peningkatan hasil belajar peserta didik dipengaruhi penggunaan Game Edukasi Quizizz.
Musica Reservata: Two Initiatory Chants for the Vòdún Worship Society in Benin. By Gilbert Rouget. Translated by Cari Friesen.
Authors: Friesen Cari 
Published: July 2021

Rouget analyzes the recordings of two pieces for vòdún initiation ceremonies for the deities of Xɛvyòsò (thunder and lightning) and Sakpàtá (the Earth), which he recorded near Porto Novo, Benin (formerly Dahomey), in 1958 and 1969, respectively. These pieces are performed in great secrecy and differ significantly in form and style from the drumming, dancing, and singing performed for the public “coming-out” ceremonies at the end of the initiates’ period of seclusion. Using staff and sonogram transcriptions, Rouget focuses on melodic and strophic repetition, as well as the function of chromaticism, a rarity in African music. These pieces reflect how the initiates move from a state of “dispossession,” or self-alienation, which the author chronicles in his photographs, before they are symbolically reborn in the public portion of the ceremony. Rouget argues for the pieces’ status as sacred works of art, originating from before colonization, that are worthy of aesthetic appreciation.
Citation: Rouget, Gilbert. Musica Reservata: Two Initiatory Chants for the Vòdún Worship Society in Benin. Translated by Cari Friesen. Ethnomusicology Translations, no. 12. Bloomington, IN: Society for Ethnomusicology, 2021.
Originally published in French as Musica Reservata. Deux chants initiatiques pour le culte des vôdoun au Bénin. Paris: Palais de l’Institut, 2006.
The Stories We Live By and the stories we won’t stand by: Measuring the impact of a free online course in ecolinguistics
Authors: Roccia Mariana , Iubini-Hampton Jessica 
Published: July 2021

Abstract
Current dominant narratives of economic growth, consumerism, and anthropocentric views on human existence, to name a few, are behind the driving forces responsible for the increasing destruction of the very own ecological systems that all life depends on. By utilizing tools of Discourse Analysis while adopting an ecological perspective, the free online course The Stories We Live By (TSWLB) offers a practical and accessible framework in which stories can be critically evaluated, questioned, and resisted. Crucially, students are encouraged to apply their newly acquired theoretical insights to search for alternative stories to live by. While current approaches of impact assessment beyond academia can be measured more readily in the sciences, it is harder to assess whether, how, and to what extent humanities research produces change in society; arguably, the digital format of the course adds to the complexity of assessing its impact. In this article, the authors aim to draw attention on the inherent value of the dissemination of traditional academic tools beyond academia. By combining both qualitative and quantitative methodologies in relation to the free online course TSWLB as a case study, the article provides an innovative tool to effectively measure impact which renders itself suitable for a wider range of disciplines across both traditional and digital humanities.
Crystal structure of 1-(2-cyanobenzyl)-3-cyano-4-phenyl-4-(2-cyanobenzyl)-1,4-dihydropyridine monohydrate, C56H42N8O
Authors: Li Yi-Da , Song Zhi-Qiang , Yue Zhi-Wei , Zhong Qi-Di , Qi Ya-Juan 
Published: July 2021

Abstract
C56H42N8O, orthorhombic, Pbcn (no. 60), a = 17.885(3) Å, b = 15.647(2) Å, c = 16.189(2) Å, V = 4530.4(11) Å3, Z = 4, R

gt
(F) = 0.0464, wR

ref
(F
2) = 0.1219, T = 296.15 K.
Zwischen Absicherung, Irrelevanz und Infragestellung der Liebe: Deutungen heiratender Paare in der Thematisierung und Aushandlung von Eheverträgen
Authors: Wutzler Michael 
Published: July 2021

ZusammenfassungEmotionalisierung und Rationalisierung sind elementare Prozesse westlich-moderner Gesellschaften. Eindrücklich lässt sich dies anhand von Paarbeziehungen nachzeichnen, deren Transformation im Übergang in die Moderne zugleich von der Autonomisierung der emotionalen Bindungen und der Verrechtlichung dieser Bindungen gekennzeichnet ist. Die den Paarbeziehungen zugrundeliegende emotionalen Bindungen folgen einer anderen Logik als die Formalisierung des Rechts und zugleich unterliegt jede intime Beziehung rechtlichen Rahmenbedingungen. Die individuelle emotionale Vergemeinschaftung über Höchstrelevanz und Nicht-Austauschbarkeit steht der Sachlichkeit, Vertragsförmigkeit und Austauschbarkeit des Rechts gegenüber. Die Individualisierung und Deinstitutionalisierung intimer Beziehungen haben die rechtliche Normierung des Intimen nicht aufgelöst. Rechtliche Regulierungen üben nicht nur Zwang aus, sondern geben auch die Möglichkeit, intime Beziehung zu gestalten. Es obliegt den Individuen in Paarbeziehungen dieses Spannungsverhältnis von zugleich emotionaler und rechtlicher Handlungsaufforderung auszuhandeln. Die Aneignung von Recht und das Bewusstsein für dessen Effekte auf die eigene Paarrealität setzen konkretes Wissen oder Annahmen über rechtliche Regularien voraus. Im Artikel wird auf Basis der Analyse von Paarinterviews der Thematisierung von Eheverträgen durch kurz vor ihrer Eheschließung stehender Paare und der Frage nachgegangen, wie Paare die Ambiguität von emotionaler Bindung und Verrechtlichung der Beziehung verhandeln. Eheverträge stellen eine Möglichkeit dar, zwischen der bestehenden Rechtslage und der Paarrealität zu vermitteln. Anhand empirischer Beispiele werden vier zentrale Deutungsmuster von Eheverträgen beschrieben.
Synthesis and coordination chemistry of silver(I), gold(I) and gold(III) complexes with picoline-functionalized benzimidazolin-2-ylidene ligands
Authors: Jahnke Mareike C. , Hahn F. Ekkehardt 
Published: July 2021

Abstract
The reactions of N-alkyl-N′-picolyl-benzimidazolium bromides or N,N′-dipicolyl-benzimidazolium bromide with silver oxide yielded the silver dicarbene complexes of the type [Ag(NHC)2][AgBr2] 1–4 (NHC = picoline-functionalized benzimidazolin-2-ylidene). The silver complexes 1–4 have been used in carbene transfer reactions to yield the gold(I) complexes of the type [AuCl(NHC)] 5–8 in good yields. A halide exchange at the metal center of complexes 5–8 with lithium bromide yielded the gold bromide complexes 9–12. Finally, the oxidation of the gold(I) centers in complexes 9–12 with elemental bromine gave the gold(III) complexes of the type [AuBr3(NHC)] 13–16. Molecular structures of selected Au(I) and Au(III) complexes have been determined by X-ray diffraction studies.
A recurrent familial partial lipodystrophy due to a monoallelic or biallelic LMNA founder variant highlights the multifaceted cardiac manifestations of metabolic laminopathies
Authors: Treiber Guillaume , Flaus Furmaniuk Ania , Guilleux Alice , Medjane Samir , Bonfanti Oriane , Schneebeli Stéphane , Bernard Céline , Le-Moullec Nathalie , Bakiri Faouzi , Pholsena Maryse , Rollot Olivier , Vatier Camille , Jarlet Eric , Jéru Isabelle , Lascols Olivier , Darcel Françoise , Domun Bhoopendrasing , Venault Adrien , Venault Sophie , Jacquemont Marie-Line , Doray Berenice , Maiza Jean-Christophe , Cogne Muriel , Vigouroux Corinne , Nobécourt Estelle 
Published: July 2021

Aims
LMNA-linked familial partial lipodystrophy type 2 (FPLD2) leads to insulin resistance-associated metabolic complications and cardiovascular diseases. We aimed to characterise the disease phenotype in a cohort of patients carrying an LMNA founder variant.

Methods
We collected clinical and biological data from patients carrying the monoallelic or biallelic LMNA p.(Thr655Asnfs*49) variant (n =  65 and 13, respectively) and 19 non-affected relative controls followed-up in Reunion Island Lipodystrophy Competence Centre, France.

Results
Two-thirds of patients with FPLD2 (n = 51) and one-third of controls (n = 6) displayed lipodystrophy and/or lean or android morphotype (P  = 0.02). Although age and BMI were not statistically different between the two groups, the insulin resistance index (median HOMA-IR: 3.7 vs 1.5, P  = 0.001), and the prevalence of diabetes, dyslipidaemia, and non-alcoholic fatty liver disease were much higher in patients with FPLD2 (51.3 vs 15.8%, 83.3 vs 42.1%, and 83.1 vs 33.3% (all P ≤ 0.01), respectively). Atherosclerosis tended to be more frequent in patients with FPLD2 (P  = 0.07). Compared to heterozygous, homozygous patients displayed more severe lipoatrophy and metabolic alterations (lower BMI, fat mass, leptin and adiponectin, and higher triglycerides P ≤ 0.03) and tended to develop diabetes more frequently, and earlier (P  = 0.09). Dilated cardiomyopathy and/or rhythm/conduction disturbances were the hallmark of the disease in homozygous patients, leading to death in four cases.

Conclusions
The level of expression of the LMNA ‘Reunionese’ variant determines the severity of both lipoatrophy and metabolic complications. It also modulates the cardiac phenotype, from atherosclerosis to severe cardiomyopathy, highlighting the need for careful cardiac follow-up in affected patients.
Magnetic resonance imaging is a valuable tool to evaluate the therapeutic efficacy of burosumab in children with X-linked hypophosphatemia
Authors: Zhukouskaya Volha V , Mannes Inès , Chaussain Catherine , Kamenický Peter , Audrain Christelle , Lambert Anne-Sophie , Nevoux Jérôme , Wicart Philippe , Briot Karine , Di Rocco Federico , Trabado Séverine , Prié Dominique , Di Somma Carolina , Colao Annamaria , Adamsbaum Catherine , Rothenbuhler Anya , Linglart Agnès 
Published: July 2021

Purpose
To examine the MRI diagnostic performance in the assessment of therapeutic response to burosumab in children with X-linked hypophosphatemia (XLH).

Design
Prospective longitudinal open cohort.

Patients
Seventeen children with XLH, average age of 10.2 ± 2.7 years, had a knee MRI at baseline and after 1 year of burosumab.

Intervention
Children received burosumab at an average dose of 1.4 ± 0.5 mg/kg during 1 year for the treatment of severe rickets (the target serum phosphate ≥ 1.2 mmol/L (≥3.7 mg/dL). The primary endpoint was the change from baseline to 12 months in rachitic lesions on knee MRI. Secondary endpoints were changes in biochemical parameters of phosphate and alkaline phosphatase (ALP).

Results
One year of treatment with burosumab significantly reduced radiological disease activity on knee MRI (by 44 ± 29% in the transverse extent of widening) which was accompanied by a significant reduction in biochemical activity, namely in serum ALP activity, by 28 ± 17%. Additionally, MRI parameters after 1 year of treatment with burosumab (the maximum width of medial physis at 12 months and the change from baseline in the maximum width of lateral physis) were associated with ALP activity at 12 months.

Conclusion
We suggest that MRI is a valuable and quantitative tool to evaluate the therapeutic response to burosumab. MRI could be an excellent alternative to standard bone radiographs for evaluation of the rachitic lesions in a clinical setting avoiding repeated exposition to ionizing radiation.
ENDOCRINOLOGY IN THE TIME OF COVID-19-2021 UPDATES: The management of diabetes insipidus and hyponatraemia
Authors: Christ-Crain Mirjam , Hoorn Ewout J , Sherlock Mark , Thompson Chris J , Wass John 
Published: July 2021

AbstractCOVID-19 has changed the nature of medical consultations, emphasizing virtual patient counselling, with relevance for patients with diabetes insipidus (DI) or hyponatraemia. The main complication of desmopressin treatment in DI is dilutional hyponatraemia. Since plasma sodium monitoring is not always possible in times of COVID-19, we recommend to delay the desmopressin dose once a week until aquaresis occurs allowing excess retained water to be excreted. Patients should measure their body weight daily. Patients with DI admitted to the hospital with COVID-19 have a high risk for mortality due to volume depletion. Specialists must supervise fluid replacement and dosing of desmopressin. Patients after pituitary surgery should drink to thirst and measure their body weight daily to early recognize the development of postoperative SIAD. They should know hyponatraemia symptoms. Hyponatraemia in COVID-19 is common with a prevalence of 20–30% and is mostly due to SIAD or hypovolaemia. It mirrors disease severity and is an early predictor of mortality. Hypernatraemia may also develop in COVID-19 patients, with a prevalence of 3–5%, especially in ICU, and derives from different multifactorial reasons, for example, due to insensible water losses from pyrexia, increased respiration rate and use of diuretics. Hypernatraemic dehydration may contribute to the high risk of acute kidney injury in COVID-19. IV fluid replacement should be administered with caution in severe cases of COVID-19 because of the risk of pulmonary oedema.
Caracterización del contenido científico divulgado en las redes Twitter e Instagram en el periodo 2018-2020
Authors: Ricciulli David 
Published: July 2021

Se presentan los avances de un proyecto de investigación que busca dar cuenta de las características principales del contenido científico en español dirigido a jóvenes y que se haya divulgado en las redes sociales Twitter e Instagram durante el periodo 2018 a 2020. La propuesta se justifica tras la percepción generalizada de una problemática sobre los procesos de consumo de información en el escenario de las redes sociales. Frente a ella, se considera importante identificar las dinámicas de producción y consumo de la información científica en este contexto para poder formular lineamientos que permitan construir estrategias de fomento de la cultura científica en el Politécnico Grancolombiano.
El estudio propuesto se llevará a cabo siguiendo una metodología de enfoque mixto que favorecería las técnicas cualitativas para lograr las valoraciones propuestas en dos de los objetivos. El uso de técnicas cuantitativas se justifica para determinar un resultado cuantificable asociado al impacto de las noticias científicas, que se busca medir.
Como hallazgo preliminar se encuentra que la alfabetización científica y los procesos para fomentarla redundan en amplios beneficios para la construcción de nuevos conocimientos y sobre ellos es necesario hacer visibles los procesos de análisis, descubrimiento y publicación (Miller, 2001).
Adicionalmente, teniendo en cuenta que el proyecto problematiza sobre contenidos científicos en línea, que por lo general consisten en elementos audiovisuales, las reflexiones asociadas a los procesos formativos que se valen de estos recursos, resultan de especial importancia (Tippett, 2016).
Se resalta la importancia de la aprehensión pública de la ciencia y su importancia en la construcción de ciudadanías participativas y la divulgación científica asociada a su capacidad de transformación social (Sinatra, G. M., & Hofer, B. K., 2016).