bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Left Atrial Enlargement Using a Convolutional Neural Network-Enabled Electrocardiogram
Authors: Jiang Junrong , Deng Hai , Xue Yumei , Liao Hongtao , Wu Shulin 
Published: January 2021

Background: Left atrial enlargement (LAE) can independently predict the development of a variety of cardiovascular diseases.Objectives: This study sought to develop an artificial intelligence approach for the detection of LAE based on 12-lead electrocardiography (ECG).Methods: The study population came from an epidemiological survey of heart disease in Guangzhou. Elderly people (3,391) over 65 years old who had both 10-s 12 lead ECG and echocardiography were enrolled in this study. The left atrial (LA) anteroposterior diameter &gt;40 mm on echocardiography was diagnosed as LAE, and the LA anteroposterior diameter was indexed by body surface area (BSA) to classify LAE into different degrees. A convolutional neural network (CNN) was trained and validated to detect LAE from normal ECGs. The performance of the model was evaluated by calculating the area under the curve (AUC), accuracy, sensitivity, specificity, and F1 score.Results: In this study, gender, obesity, hypertension, and valvular heart disease seemed to be related to left atrial enlargement. The AI-enabled ECG identified LAE with an AUC of 0.949 (95% CI: 0.911–0.987). The sensitivity, specificity, accuracy, precision, and F1 score were 84.0%, 92.0%, 88.0%, 91.3%, and 0.875, respectively. Physicians identified LAE with sensitivity, specificity, accuracy, precision, and F1 scores of 38.0%, 84.0%, 61.0%, 70.4%, and 0.494, respectively. In classifying LAE in different degrees, the AUCs of identifying normal, mild LAE, and moderate-severe LAE ECGs were 0.942 (95% CI: 0.903–0.981), 0.951 (95% CI: 0.917–0.987), and 0.998 (95% CI: 0.996–1.00), respectively. The sensitivity, specificity, accuracy, positive predictive value, and F1 scores of diagnosing mild LAE were 82.0%, 92.0%, 88.7%, 89.1%, and 0.854, while the sensitivity, specificity, accuracy, positive predictive value, and F1 scores of diagnosing moderate-severe LAE were 98.0%, 84.0%, 88.7%, 96.1%, and 0.969, respectively.Conclusions: An AI-enabled ECG acquired during sinus rhythm permits identification of individuals with a high likelihood of LAE. This model requires further refinement and external validation, but it may hold promise for LAE screening.
The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection
Authors: Mao Yanfei , Xu Bo , Guan Wenbin , Xu Dunfeng , Li Feng , Ren Rongrong , Zhu Xiaoyan , Gao Yuan , Jiang Lai 
Published: January 2021

BackgroundThe majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). The therapeutic effect of dexamethasone may be related to its ability to improve cortical function. Recent study showed that dexamethasone can reduce COVID-19 deaths by up to one third in critically ill patients. The aim of this article is to investigate whether SARS-CoV-2 can attack the adrenal cortex to aggravate the relative adrenal insufficiency.MethodsWe summarized the clinical features of COVID-19 reported in currently available observational studies. ACE2 and TMPRSS2 expression was examined in human adrenal glands by immunohistochemical staining. We retrospectively analyzed serum cortisol levels in critically ill patients with or without COVID-19.ResultsHigh percentage of critically ill patients with SARS-COV-2 infection in the study were treated with vasopressors. ACE2 receptor and TMPRSS2 serine protease were colocalized in adrenocortical cells in zona fasciculata and zona reticularis. We collected plasma cortisol concentrations in nine critically ill patients with COVID-19. The cortisol levels of critically ill patients with COVID-19 were lower than those in non-COVID-19 critically ill group. Six of the nine COVID-19 critically ill patients had random plasma cortisol concentrations below 10 µg/dl, which met the criteria for the diagnosis of CIRCI.ConclusionWe demonstrate that ACE2 and TMPRSS2 are colocalized in adrenocortical cells, and that the cortisol levels are lower in critically ill patients with COVID-19 as compared to those of non-COVID-19 critically ill patients. Based on our findings, we recommend measuring plasma cortisol level to guide hormonal therapy.
Protocol for Sampling Sequential Fin Spine Growth Intervals for Isotope Analysis in the Atlantic Bluefin Tuna
Authors: Luque Patricia Lastra , Sakai Saburo , Murua Hilario , Arrizabalaga Haritz 
Published: January 2021

BackgroundMicromilled fish otoliths (ear bones) have been widely used for stable oxygen (δ18O) and carbon (δ13C) isotope analysis. The first dorsal fin spine is routinely used for ageing in the eastern Atlantic bluefin tuna (ABFT) population; however, stable isotope analysis remains unapplied in this hard structure. The objective of the present protocol is to achieve a sequential sampling of growth layers in the ABFT fin spine at high spatial resolution and along growth trajectory for stable isotope analysis.MethodsWe used a micromilling and micro-powder collecting technique for sequentially sampling annual growth layers of the fin spine bone collected from freshly caught ABFT. We assessed the carbonate content and the optimal drilling amount to ensure enough powder quantity was recovered from each annual growth band to accommodate accurate measurement of the δ18O and δ13C values.ResultsThe optimal drilling path included 20 drilling lines in 49 μm, with 400 μm depth and 900 μm-line width, which represents a time resolution of about 2.5 months. The minimum powder quantity required from each annual growth layer for δ18O and δ13C isotope analysis was approximately 180 μg because the carbonate contents in the fin spine powder was 5–6%. The δ18O profile assayed in the last growth intervals coincide with the surface δ18Oseawater for the southern west waters off the Norwegian coast, where the tuna was caught. The fluctuating pattern in the second growth interval may reflect certain fidelity to the Norwegian SE and Swedish SW coast and/or otherwise to the US west coast. The δ13Cspine displayed a larger temporal variability along the growth transect that may be explained by several factors including differences in habitat use, behavior, and even trophic level.ConclusionBased on the result obtained, we present an optimal standard protocol for the sampling of sequential, annually formed growth layers in the fin spine bone for stable isotope analysis using the micro-milling as a high precision technique. This protocol is particularly useful in endangered and/or protected species for which fin spines represent a non-lethal alternative to otoliths opening new research avenues to improve their management and conservation.
Survival Factors and Metabolic Pathogenesis in Elderly Patients (≥65) With COVID-19: A Multi-Center Study
Authors: Mei Qi , Wang Amanda Y. , Bryant Amy , Yang Yang , Li Ming , Wang Fei , Du Shangming , Kurts Christian , Wu Patrick , Ma Ke , Wu Liang , Chen Huawen , Luo Jinlong , Li Yong , Hu Guangyuan , Yuan Xianglin , Li Jian 
Published: January 2021

Background: Elderly patients infected with COVID-19 are reported to be facing a substantially increased risk of mortality. Clinical characteristics, treatment options, and potential survival factors remain under investigation. This study aimed to fill this gap and provide clinically relevant factors associated with survival of elderly patients with COVID-19.Methods: In this multi-center study, elderly patients (age ≥65 years old) with laboratory-confirmed COVID-19 from 4 Wuhan hospitals were included. The clinical end point was hospital discharge or deceased with last date of follow-up on Jul. 08, 2020. Clinical, demographic, and laboratory data were collected. Univariate and multivariate analysis were performed to analyze survival and risk factors. A metabolic flux analysis using a large-scale molecular model was applied to investigate the pathogenesis of SARS-CoV-2 with regard to metabolism pathways.Results: A total of 223 elderly patients infected with COVID-19 were included, 91 (40.8%) were discharged and 132 (59.2%) deceased. Acute respiratory distress syndrome (ARDS) developed in 140 (62.8%) patients, 23 (25.3%) of these patients survived. Multivariate analysis showed that potential risk factors for mortality were elevated D-Dimer (odds ratio: 1.13 [95% CI 1.04 - 1.22], p = 0.005), high immune-related metabolic index (6.42 [95% CI 2.66–15.48], p &lt; 0.001), and increased neutrophil-to-lymphocyte ratio (1.08 [95% 1.03–1.13], p &lt; 0.001). Elderly patients receiving interferon atmotherapy showed an increased probability of survival (0.29 [95% CI 0.17–0.51], p &lt; 0.001). Based on these factors, an algorithm (AlgSurv) was developed to predict survival for elderly patients. The metabolic flux analysis showed that 12 metabolic pathways including phenylalanine (odds ratio: 28.27 [95% CI 10.56–75.72], p &lt; 0.001), fatty acid (15.61 [95% CI 6.66–36.6], p &lt; 0.001), and pyruvate (12.86 [95% CI 5.85–28.28], p &lt; 0.001) showed a consistently lower flux in the survivors vs. the deceased subgroup. This may reflect a key pathogenic mechanism of COVID-19 infection.Conclusion: Several factors such as interferon atmotherapy and recreased activity of specific metabolic pathways were found to be associated with survival of elderly patients. Based on these findings, a survival algorithm (AlgSurv) was developed to assist the clinical stratification for elderly patients. Dysregulation of the metabolic pathways revealed in this study may aid in the drug and vaccine development against COVID-19.
Preliminary Outcome of a Novel Edge-to-Edge Closure Device to Manage Mitral Regurgitation in Dogs
Authors: Liu Bo , Leach Stacey B. , Pan Wenzhi , Zheng Fangyu , Jia Liujun , Zhou Xueying , Li Jing 
Published: January 2021

Background: Veterinary management of mitral valve regurgitation due to mxyomatous valve disease in dogs is limited to medical treatments, which only postpones the onset of congestive heart failure or alleviates clinical symptoms. Most surgical procedures to manage this condition in humans require cardiopulmonary bypass and have a high risk of complications.Animals: Eight dogs with naturally occurring mitral valve regurgitation.Methods: Prospective observational study. All dogs were treated with a novel edge-to-edge transcatheter device named ValveClamp. The total surgical procedural time and total catheterization time were recorded. Echocardiographic variables measured pre- and post-procedure were compared using Wilcoxin-signed rank test with a P &lt; 0.05 considered significant. Data were expressed as median and interquartile range and absolute numbers and percentages.Results: The procedural success rate was 100% and all the dogs survived without complications. The median (interquartile range) total surgical procedural time was 86.5 (76–96.2) minutes and catheterization time was 23.5 (22–33.8) minutes. Echocardiography revealed a significant reduction in mitral regurgitation severity in all dogs following the procedure based on both a reduced mitral regurgitant maximum jet area (P = 0.012) and a reduced mitral regurgitant maximum jet area to left atrial area (P = 0.018).Conclusion: The ValveClamp device is effective at reducing the severity of mitral regurgitation in dogs with naturally occurring myxomatous valve disease.
The Early History of God: Yahweh and the Other Deities in Ancient Israel
Authors: Lumingkewas Marthin Steven 
Published: January 2021

Mark S. Smith merupakan satu di antara peneliti Kitab Ibrani; khususnya teks-teks ANET (Ancient Near Eastern Text) bersama dengan beberap ahli bahasa Semit barat seperti Frank Moore Cross, Michael D. Morgan dan Brevard S. Child. Akan tetapi, Smith lebih dikenal dengan model interpretasi Israel sebagai satu entitas dengan bangsa sekitarnya – dalam hal ini Kanaan. Pendekatan ini menghasilkan metodologi penting untuk melihat Israel dengan cara berbeda – yaitu Israel sebagai bangsa yang identik dengan bangsa-bangsa Kanaan – berlawanan dengan pemahaman yang selama ini melihat kedua bangsa sebagai vis-a-vis berdasarkan informasi Kitab Ibrani. Buku ini berupaya menggambarkan upaya memahami Israel tidak dapat diperoleh melalui sejarah semata. Berbicara mengenai Israel sebagai umat dengan beberapa mishpat, kemudian berlanjut menjadi sebuah bangsa dalam koridor monarki, sampai mereka masuk dan kembali dari pembuangan; termasuk di dalamnya sistem agama mereka, hanya dapat dilakukan melalui memori. Memori yang dimaksud Smith dalam hal ini adalah melalui proses convergence dan differentiation. Pada masa awal Israel, bangsa ini tidak berbeda dengan bangsa-bangsa sekitarnya; termasuk di dalamnya sistem keagaman yang mereka anut. El, Baal, Anat dan Asherah menjadi allah utama Israel. El menjadi sesembahan utama Israel bersamaan dengan Yahweh. Baal menjadi sesembahan Daud ketika ia berseru Baal Perazim (allah memberikan terobosan) dalam 2 Samuel 5:20 dan 1 Tawarik 14:11 (hal.74-76).
PENGARUH KARAKTERISTIK KOMITE AUDIT TERHADAP PENGUNGKAPAN ETIKA SUKARELA DAN IMPLIKASI TERHADAP HARGA SAHAM
Authors: Laksito Herry 
Published: January 2021

The objectives of this paper is to investigate the impact of audit committee characteristics on voluntary ethics disclosure and its implications on stock price. Independent variable in this paper is measured using four elements of audit committee characteristics consist of competency, the number of meeting, scope, tenure and multiple directorships. On the other hand this paper uses the stock price as dependent variable and voluntary ethical disclosure as mediating variable. The population in this paper are all companies listed on the Indonesian Stock Exchange in 2018. Sample selection method using purposive sampling and the number of samples attained as many as 94 companies. This analysis used in this paper is a multiple regression analysis. The results of this study show that the number of meeting and multiple directorship were significantly associated with the voluntary ethics disclosure, while competency, size and tenure were not significantly associated with the voluntary ethics disclosure. The study also found a positive and significant effect between voluntary ethical disclosure and company stock prices.
PENGEMBANGAN MEDIA PUZZLE PENA (PENYAKIT MENULAR) KELAS V SEKOLAH DASAR
Authors: Ardiyanto Asep , Agustini Ferina , Septi Risqiana Sholeha  
Published: January 2021

Penelitian ini bertujuan untuk mengetahui kevalidan dan kepraktisan pengembangan media puzzle pena (penyakit menular) untuk kelas V Sekolah Dasar. Jenis penelitian ini adalah penelitian dan pengembangan oleh Borg & Gall. Populasi dalam penelitian ini adalah seluruh siswa kelas V SD Negeri 3 Bacem. Sampel yang diamati adalah 19 siswa kelas V. Pengembangan menghasilkan media puzzle pena (penyakit menular) pembelajaran Pendidikan Jasmani, Olahraga dan Kesehatan yang valid dan praktis. Hasil penelitian ini diperoleh melalui hasil validasi ahli media dan ahli materi dengan jumlah rata-rata keidealan yaitu 91,87% untuk hasil validasi media dan 95,31% untuk hasil validasi materi serta hasil tanggapan guru dan siswa terhadap media puzzle pena (penyakit menular) dengan rata-rata keidealan 92,5% untuk hasil tanggapan guru dan 95,5% untuk hasil tanggapan siswa. Hal ini dapat disimpulkan bahwa media pembelajaran puzzle pena (penyakit menular) untuk kelas V Sekolah Dasar yang dikembangkan termasuk dalam kategori “Sangat Baik” untuk digunakan dalam mata pelajaran PJOK kelas V Sekolah Dasar.
GAYA KEPEMIMPINAN DAN LINGKUNGAN KERJA BERPENGARUH TERHADAP KINERJA KARYAWAN MELALUI MOTIVASI KERJA PT. MINA JAYA LESTARI SURABAYA
Authors: Al Anva Dewi Layungsari  , Untung Lasiyono  , Tri Ari Prabowo  
Published: January 2021

Dijelaskan analisa pengaruh gaya kepemimpinan dan lingkungan kerja terhadap kinerja karyawan melalui motivasi kerja pada PT.Mina Jaya Lestari. Sampel yang digunakan adalah 113 orang. Teknik memakai non probability dengan teknik Random sampling. Analisis data menggunakan path analysis. Diperoleh hasil Gaya Kepemimpinan dan lingkungan kerja berpengaruh positif dan signifikan terhadap Motivasi Kerja Karyawan pada PT. Mina Jaya Lestari Surabaya, Gaya Kepemimpinan, lingkungan kerja dan motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan pada PT. Mina Jaya Lestari Surabaya. Hasil pengujian hipotesis menggunakan ujit dan uji-sobel. Dimana hasil tersebut menunjukkan terdapat pengaruh signifikan, hipotesis bisa diterima dan terbukti kebenarannya.
PENGARUH RISIKO LIKUIDITAS DAN PERTUMBUHAN PENJUALAN TERHADAP HARGA SAHAM PADA PERUSAHAAN PROPERTI DAN REAL ESTATE
Authors: Nur Maulida Chasanah  , Aji Prasetyo  
Published: January 2021

Saham termasuk dalam jenis investasi di pasar modal yang digunakan oleh banyak investor, maka investor perlu untuk mengamati harga saham dari suatu perusahaan sebelum memulai investasi. Variabel yang digunakan untuk mengukur harga saham menggunakan Risiko Likuiditas dan Pertumbuhan Penjualan. Penelitian ini mempunyai tujuan yaitu untuk mengetahui apakah ada pengaruh antara variabel bebas terhadap variabel terikat yang dipilih dalam penelitian ini. Dokumentasi adalah teknik yang dipilih untuk pengumpulan data. Teknik untuk mengalisis data dalam penelitian ini menerapkan analisis regresi linier berganda, uji asumsi klasik, serta uji t dan uji-f. Hasil uji-t variabel Risiko Likuiditas memperoleh nilai 0,009 karena (0,009 < 0,05) maka Risiko Likuiditas memengaruhi harga saham. Hasil uji t variabel Pertumbuhan Penjualan memperoleh nilai 0,762 karena (0,762 > 0,05) maka Pertumbuhan Penjualan tidak memengaruhi harga saham. Sedangkan untuk hasil uji-f memperoleh nilai 0,019 karena (0,019 < 0,05) maka variabel Risiko Likuiditas dan Pertumbuhan Penjualan memengaruhi harga saham secara bersama-sama.
Pengaruh Lingkungan Kerja dan Motivasi Kerja Terhadap Semangat Kerja PT. Alkonusa Teknik Interkon Surabaya
Authors: Amrul Khakim  , Mochammad Munir Rachman  
Published: January 2021

Penelitian yang akan dilakukan ini guna mengetahui apakah ada faktor yang mempengaruhi dari kinerja karyawan PT. Alkonusa Teknik Interkon Surabaya. Dimana faktor tersebut memliki dua variabel yaitu lingkungan kerja dan motivasi kerja Karyawan yang memiliki motivasi yang besar dalam bekerja bertujuan untuk perusaahan di PT. Alkonusa Teknik Interkon Surabaya, pengambilan data yang digunakan untuk mengukur menggunakan alat bantu SPSS. Teknik sampling digunakan untuk dipakai yakni metode kuisioner, observasi, dokumentasi. Dalam penelitian ini terdapat beberapa teknik pengujian yang terdiri dari “uji instrumen, uji asumsi klasik dan uji regresi linier berganda”. Hasil uji regresi linier berganda menunjukkan koefisien regresi pada variabel X1 0,379 dan variabel X2 0,622. Hasil Uji T dapat disimpulkan bahwa nilai lingkungan kerja (X1) t-hitung = 4.226 dan nilai sig. 0,000. Motivasi kerja (X2) t-hitung = 8.098 dan nilai sig. 0,000. Sedangkan hasil Uji F menunjukkan hasil nilai variabel lingkungan kerja dan motivasi kerja F simultan 50.270 dan nilai sig. 0,000. Dari hasil penelitian dapat disimpilkan bahwa lingkungan kerja dan motivasi kerja berpengaruh terhadap semangat kerja karyawan yang berada di PT. Alkonusa Teknik Interkon, Surabaya.
PENGARUH KEPEMIMPINAN DAN LOYALITAS KERJA TERHADAP PRODUKTIVITAS KARYAWAN PADA CV. SALSABILA GROUP DI GRESIK
Authors: Domy Budi Santoso  , Siti Samsiyah  
Published: January 2021

Penelitian ini bermaksud untuk menilai dan menelaah dampak kepemimpinan dan loyalitas kerja terhadap produktivitas karyawan CV. Salsabila Group di Gresik, dengan jenis penelitian kuantitatif. Sampel dimabil dari semua karyawan yang berjumlah 73 responden memepergunakan metode sampling jenuh. Data diperoleh dari hasil penyebaan kuesioner, Ulasan menggunakan regresi linear, uji validitas dan uji realibilitas. Uji asumsi klasik yang meliputi Uji Normalitas Uji Heteroskedasitas Uji multikolinieritas Uji Autokorelasi. dan uji hipotesis : Uji t, Uji F. Hasil penelitian menunjukkan bahwa kepemimpinan dan loyalitas kerja secara simultan dan parsial berpengaruh secara signifikan terhadap produktivitas karyawan pada CV. Salsabila Group di Gresik.
PENGARUH LINGKUNGAN KERJA & STRESS KERJA TERHADAP KINERJA KARYAWAN PT. DWI MULYA JAYA MOJOKERTO
Authors: Jaeni Siti Qomaroh Jaenun Musolikah  , M. Munir Rachman  , Suharyanto  
Published: January 2021

Dijelaskan riset ini menganalisa lingkungan kerja serta stress kerja karyawan PT. Dwi Mulya Jaya Mojokerto terhadap kinerja karyawan. Riset ini memakai pendekatan kuantitatif deskriptif. Adapun populasi riset ini yakni seluruh karyawan PT. Dwi Mulya Jaya Mojokerto sejumlah 76 karyawan. Teknik sampel memakai sampling jenuh. Didapatkan hasil riset thitung X1 4,338 serta sig. ,010 < ,05. X2 4,916 serta sig. ,023 < ,05 serta uji bersamaan 37,075 serta sig. ,000< ,05. Artinya telah terbukti adanya pengaruh secara terpisah serta bersamaan variabel bebas terhadap variabel terikat
PENGARUH LIKUIDITAS DAN GCG TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN KONSTRUKSI YANG TERDAFTAR DI BEI
Authors: Falentina Purmintasari  , Yuni Sukandani  
Published: January 2021

Supaya memahami dampak dari likuiditas dan GCG terhadap nilai perusahaan di usaha konstruksi yang tercantum di IDXI, maka peneliti melakukan riset ini. Laporan keuangan usaha konstruksi yang tercantum di IDX merupakan populasi di riset ini. Ada 5 perusahaan konstruksi yang diperoleh menggunakan teknik purposive sampling menjadi sampel penelitian. Dokumentasi merupakan metode pengumpulan data dan menggunakan analisis regresi linear berganda, uji t dan uji F. Hasil penelitian menunjukkan bahwa likuiditas berpengaruh terhadap nilai perusahaan (0,025 < 0,05), kepemilikan institusional tidak berdampek terhadap nilai perusahaan (0,214 > 0,05), kepemilikan manajerial terhadap nilai perusahaan (0,040 < 0,05). Sedangkan secara simultan Fhitung pada variabel likuiditas, kepemilikan institusional dan kepemilikan manajerial berpengaruh terhadap nilai perusahaan dengan signifikan senilai 0,048 < 0,05.
Analisis Proksimat Abon Bonggol Pisang Dengan Fortifikasi Tepung Tempe Dan Lesitin
Authors: Rahayu Sihmawati Rini , Agustiyah Rosida Dwi 
Published: January 2021

The aim of this research was to evaluate a proximate test (protein, fat, water content and carbohydrate) shredded banana corm with tempeh flour and lechitin fortification. This research is an experimental study using a completely randomized design factorial pattern. The first treatment was: Tempe soybean flour (T) with a level of T1 (5%), T2 (10%) and T3 (15%). The second treatment was lecithin (L) with levels of L1 (3%), L2 (5%) and L3 (7%) so that 9 treatment combinations were obtained. The collected data were analyzed with a 2-way classification variance test (analysis of variance). If there is a difference between treatments followed by LSD test. Proximate test results on the protein content of shredded banana corm showed that the addition of tempeh flour (T) had a very significant effect on protein content (P <0.01), while the addition of lecithin (L) was not significant (P> 0.05) both tempeh flour and lechitin did not significant on fat content and water content (P> 0.05). Tempeh flour (T) has a very significant effect on carbohydrate content (P <0.01), while the addition of lecithin (L) is not significant (P> 0.05).

Keywords: banana corn, shredded, tempeh flour, lecithin, proximate test