bluuebunny/crossref_metadata_2025_split huggingface dataset:
The COVID‐19 crisis and policy responses by continental European welfare states
Authors: Cantillon Bea , Seeleib‐Kaiser Martin , van der Veen Romke 
Published: March 2021

AbstractSocial protection in Germany, Belgium and the Netherlands share Bismarckian roots. Over time, these welfare states were however in constant flux and incorporated to a greater or lesser extend elements of both the Anglo‐Saxon and Nordic models. While the Netherlands has from the beginning deviated from the Bismarckian model, in recent years this welfare state has undergone important reforms that have made it increasingly evolve into a “Bismarck cum Beveridge” model. Germany and Belgium also witnessed a dual transformation, with retrenched earnings‐related benefits for long‐term unemployed and an increasing number of atypically employed people on the one hand and expanded social security to the so‐called “new social risks” on the other. It is against this changing institutional background that we can understand the similarities and differences in the extent to which these three continental welfare states used traditional social insurance systems to buffer the social and economic consequences of confinement. First, all three countries strengthened to varying degrees social protection systems for the active age population. So conceived, the policy responses were a response to the dual transformation of social protection that took place in recent decades without, however, changing its course. Second, the extent to which continental welfare states made use of existing social insurance schemes seems to be related to the extent to which these welfare states have moved in the Anglo‐Saxon direction.
Social policy in the face of a global pandemic: Policy responses to the COVID‐19 crisis
Authors: Béland Daniel , Cantillon Bea , Hick Rod , Moreira Amílcar 
Published: March 2021

AbstractHow have welfare states responded to the coronavirus pandemic? In this introductory article, we provide a synopsis of papers that comprise this special issue on social policy responses to COVID‐19, an overview of some of the key questions they raise, and some provisional answers to these questions. Our conclusions are threefold: first, these social policy responses, while entailing new developments in many countries, nonetheless reflect, at least in part, existing national policy legacies. Second, these responses can be understood as a form of “emergency Keynesianism,” which is characterized by the massive use of deficit spending during economic crises, with the aim of to supporting rather than challenging core capitalist institutions. Third, there are clear differences in terms of the nature of the reforms enacted during the initial phase of the COVID‐19 crisis as compared to reforms enacted as a response to the 2008 financial crisis.
Plastidial acyl carrier protein Δ9‐desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum
Authors: Smith Richard , Jouhet Juliette , Gandini Chiara , Nekrasov Vladimir , Marechal Eric , Napier Johnathan A. , Sayanova Olga 
Published: March 2021

SUMMARYThe unicellular marine diatom Phaeodactylum tricornutum accumulates up to 35% eicosapentaenoic acid (EPA, 20:5n3) and has been used as a model organism to study long chain polyunsaturated fatty acids (LC‐PUFA) biosynthesis due to an excellent annotated genome sequence and established transformation system. In P. tricornutum, the majority of EPA accumulates in polar lipids, particularly in galactolipids such as mono‐ and di‐galactosyldiacylglycerol. LC‐PUFA biosynthesis is considered to start from oleic acid (18:1n9). EPA can be synthesized via a series of desaturation and elongation steps occurring at the endoplasmic reticulum and newly synthesized EPA is then imported into the plastids for incorporation into galactolipids via an unknown route. The basis for the flux of EPA is fundamental to understanding LC‐PUFA biosynthesis in diatoms. We used P. tricornutum to study acyl modifying activities, upstream of 18:1n9, on subsequent LC‐PUFA biosynthesis. We identified the gene coding for the plastidial acyl carrier protein Δ9‐desaturase, a key enzyme in fatty acid modification and analyzed the impact of overexpression and knock out of this gene on glycerolipid metabolism. This revealed a previously unknown role of this soluble desaturase in EPA synthesis and production of triacylglycerol. This study provides further insight into the distinctive nature of lipid metabolism in the marine diatom P. tricornutum and suggests additional approaches for tailoring oil composition in microalgae.
Can non‐Mendelian inheritance of extrachromosomal circular DNA‐mediated EPSPS gene amplification provide an opportunity to reverse resistance to glyphosate?
Authors: Jugulam Mithila 
Published: March 2021

AbstractAmplification of herbicide target genes conferring naturally evolved resistance in weed species is one of the novel and more recently known mechanisms of resistance. Numerous agriculturally important dicot and monocot weeds, including Palmer amaranth (Amaranthus palmeri), common waterhemp (Amaranthus tuberculatus) and Italian ryegrass (Lolium multiflorum), have evolved resistance to glyphosate via this mechanism. Specifically, the extrachromosomal amplification of the 5‐enopyruvlyshikimate‐3‐phosphate synthase (EPSPS) gene, the molecular target of glyphosate, was found to be the basis for glyphosate resistance in Amaranthus weeds, for example Palmer amaranth and common waterhemp. Nonetheless, the mechanism of extrachromosomal amplification of the EPSPS gene was different in these weeds. These extrachromosomal elements are newly identified genetic components and represent a paradigm shift in genetics to provide an adaptive advantage to organisms to withstand stress. Also, the extrachromosomal amplified copies are touted to be unstable in many organisms, due to their unpredictable behaviour during mitosis or meiosis, suggesting that they may have not integrated into the host genome. Therefore, it is reasonable to hypothesise that, in the absence of selection, the number of EPSPS copies may dissipate leading to the reversal of glyphosate resistance to susceptibility.
Le transfert singulier pour la formule des traces de Jacquet–Rallis
Authors: Chaudouard Pierre-Henri , Zydor Michał 
Published: March 2021

RésuméLa formule des traces relative de Jacquet–Rallis (pour les groupes unitaires ou les groupes linéaires généraux) est une identité entre des périodes des représentations automorphes et des distributions géométriques. Selon Jacquet et Rallis, une comparaison de ces deux formules des traces relatives devrait aboutir à une démonstration des conjectures de Gan–Gross–Prasad et Ichino–Ikeda pour les groupes unitaires. Les termes géométriques des groupes unitaires ou des groupes linéaires sont indexés par les points rationnels d'un espace quotient commun. Nous établissons que ces termes géométriques peuvent être vus comme des fonctionnelles sur des espaces d'intégrales orbitales semi-simples régulières locales. En outre, nous montrons que point par point ces distributions sont en fait égales, via l'identification des espaces d'intégrales orbitales locales donnée par le transfert et le lemme fondamental (essentiellement connus dans cette situation). Cela donne leur comparaison et cela clôt la partie géométrique du programme de Jacquet–Rallis. Notre résultat principal est donc un analogue de la stabilisation de la partie géométrique de la formule des traces due à Langlands, Kottwitz et Arthur.
Acute hypobaric hypoxia and cardiac energetic response in prepubertal rats: Role of nitric oxide
Authors: La Padula Pablo H. , Czerniczyniec Analia , Bonazzola Patricia , Piotrkowski Bárbara , Vanasco Virginia , Lores‐Arnaiz Silvia , Costa Lidia E. 
Published: March 2021

New Findings

What is the central question of this study?
In adult rat hearts, exposure to hypobaric hypoxia increases tolerance to hypoxia–reoxygenation, termed endogenous cardioprotection. The mechanism involves the nitric oxide system and modulation of mitochondrial oxygen consumption. What is the cardiac energetic response in prepubertal rats exposed to hypobaric hypoxia?

What is the main finding and its importance?
Prepubertal rats, unlike adult rats, did not increase tolerance to hypoxia–reoxygenation in response acute exposure to hypobaric hypoxia, which impaired cardiac contractile economy. This finding could be related to a failure to increase nitric oxide synthase expression, hence modulation of mitochondrial oxygen consumption and ATP production.

AbstractStudies in our laboratory showed that exposure of rats to hypobaric hypoxia (HH) increased the tolerance of the heart to hypoxia–reoxygenation (H/R), involving mitochondrial and cytosolic nitric oxide synthase (NOS) systems. The objective of the present study was to evaluate how the degree of somatic maturation could alter this healthy response. Prepubertal male rats were exposed for 48 h to a simulated altitude of 4400 m in a hypobaric chamber. The mechanical energetic activity in perfused hearts and the contractile functional capacity of NOS in isolated left ventricular papillary muscles were evaluated during H/R. Cytosolic nitric oxide (NO), production of nitrites/nitrates (Nx), expression of NOS isoforms, mitochondrial O2 consumption and ATP production were also evaluated. The left ventricular pressure during H/R was not improved by HH. However, the energetic activity was increased. Thus, the contractile economy (left ventricular pressure/energetic activity) decreased in HH. Nitric oxide did not modify papillary muscle contractility after H/R. Cytosolic p‐eNOS‐Ser1177 and inducible NOS expression were decreased by HH, but no changes were observed in NO production. Interestingly, HH increased Nx levels, but O2 consumption and ATP production in mitochondria were not affected by HH. Prepubertal rats exposed to HH preserved cardiac contractile function, but with a high energetic cost, modifying contractile economy. Although this could be related to the decreased NOS expression detected, cytosolic NO production was preserved, maybe through the Nx metabolic pathway, without modification of mitochondrial ATP production and O2 consumption. In this scenario, the treatment was unable to increase tolerance to H/R as observed in adult animals.
A Mobile Mathieu Oscillator Model for Vibrational Locomotion of a Bristlebot
Authors: Tallapragada Phanindra , Gandra Chandravamsi 
Published: March 2021

Abstract
Terrestrial locomotion that is produced by creating and exploiting frictional anisotropy is common amongst animals such as snakes, gastropods, and limbless lizards. In this paper we present a model of a bristlebot that locomotes by generating frictional anisotropy due to the oscillatory motion of an internal mass and show that this is equivalent to a stick–slip Mathieu oscillator. Such vibrational robots have been available as toys and theoretical curiosities and have seen some applications such as the well-known kilobot and in pipe line inspection, but much remains unknown about this type of terrestrial locomotion. In this paper, motivated by a toy model of a bristlebot made from a toothbrush, we derive a theoretical model for its dynamics and show that its dynamics can be classified into four modes of motion: purely stick (no locomotion), slip, stick–slip, and hopping. In the stick mode, the dynamics of the system are those of a nonlinear Mathieu oscillator and large amplitude resonance oscillations lead to the slip mode of motion. The mode of motion depends on the amplitude and frequency of the periodic forcing. We compute a phase diagram that captures this behavior, which is reminiscent of the tongues of instability seen in a Mathieu oscillator. The broader result that emerges in this paper is that mobile limbless continuum or soft robots can exploit high-frequency parametric oscillations to generate fast and efficient terrestrial motion.
Increasing Life Span by Cooling the Laminated Core Segment of Motors to Reduce Material and Energy Costs Over the Lifecycle of Motors
Authors: Lucas Stephen , Bari Saiful 
Published: March 2021

Abstract
Internal losses in motor windings and cores result in unwanted heat. According to International Energy Agency, majority of motors in service today are AC induction motors between 0.75 and 375 kW. For these motors, internal losses (heat) are conducted to the surrounding environment by internal conduction to the casing and then to the surrounding environment by convection. For small motors of up to 5 kW, the cores are mounted in a simple round housing and as they get larger the housings are ribbed and external fans are installed. Motors are designed assuming an environmental maximum temperature of 40 °C and with a hot spot allowance of 10 °C can withstand up to 155 °C (class F) at the winding position. However, due to changes in environmental temperatures, system voltage variations and harmonics, winding temperatures often exceed this limit. Consequently, this range of motors last only approximately 3 years. This paper investigates the possible application of thermoelectric cooler (TEC) to increase the heat flow from the core to reduce the temperature at the winding position, potentially providing longer insulation and motor life. For small motors, they can be simply attached to the outer surface. For larger motors with frames incorporating cooling ribs, they could be installed between the cores and the frames. The experimental results found that the application of TEC reduces the winding temperatures by 25.4%. Ability to incorporate this technology allows the opportunity to add a controlled device that can reduce temperatures at the windings when the temperatures exceed normal ratings.
Standard maintenance therapy versus local consolidative radiation therapy and standard maintenance therapy in 1–5 sites of oligometastatic non-small cell lung cancer: a study protocol of phase III randomised controlled trial
Authors: Tibdewal Anil , Agarwal Jai Prakash , Srinivasan Shashank , Mummudi Naveen , Noronha Vanita , Prabhash Kumar , Patil Vijay , Purandare Nilendu , Janu Amit , Kannan Sadhna 
Published: March 2021

IntroductionTwo-phase II randomised studies have shown a significant benefit of local consolidation therapy in oligometastatic non-small cell lung cancer (NSCLC). This phase III randomised controlled trial (RCT) will evaluate the efficacy of local consolidation radiation therapy (RT) in oligometastases (OM) NSCLC after completion of initial systemic therapy.Methods and analysisThis is a single-centre phase III RCT of OM NSCLC patients. One hundred and ninety patients will undergo 1:1 randomisation to either standard maintenance therapy (control arm) or local consolidation RT and standard maintenance therapy (experimental arm). Patients will be stratified into the number of OM sites (1–2 vs 3–5), nodal metastases (N0–N1 vs N2–N3) and presence or absence of brain metastases. Stereotactic body radiation therapy to all the oligometastatic sites and definitive RT to primary disease will be given in the experimental arm. The primary endpoint is overall survival and secondary endpoints include progression-free survival, local control of OM sites, new distant metastases free survival, objective response rate, toxicity and quality of life. Translation endpoint include circulating tumour cells and radiomics using texture analysis.Ethics and disseminationAll patients will be provided with a written informed consent form which needs to be signed before randomisation. The study is approved by the institutional ethics committee-II (project number 3445) and registered with Clinical Trials Registry—India, dated 21 April 2020.Trial registration numberCTRI/2020/04/024761; Pre-Results.
UK advanced practice nurses’ experiences of the COVID-19 pandemic: a mixed-methods cross-sectional study
Authors: Wood Emily , King Rachel , Senek Michaela , Robertson Steve , Taylor Bethany , Tod Angela , Ryan Anthony 
Published: March 2021

ObjectiveThe aim of the study was to understand the experiences of advanced practice nurses (APNs) in the UK during the 2020 COVID-19 pandemic, particularly in relation to safety, shortages and retention.DesignA cross-sectional, mixed-methods survey.SettingAPNs in any UK setting.ParticipantsThe survey was sent to an existing UK-wide cohort of APNs. 124 APNs responded (51%).ResultsUK-based APNs in this study reported shortages of staff (51%) and personal protective equipment (PPE) (68%) during the first 3 months of the coronavirus outbreak. Almost half (47%) had considered leaving their job over the same 3 months. Despite difficulties, there were reports of positive changes to working practice that have enhanced care.ConclusionUK APNs report COVID-19-related shortages in staff and equipment across primary and secondary care and all regions of the UK. Shortages of PPE during a pandemic are known to be a factor in the development of mental health sequelae as well as a risk factor for increased turnover and retention issues. Half of APNs surveyed were considering a change in job. The UK risks a further crisis in staff morale and retention if this is not acknowledged and addressed. APNs also expressed concern about patients not receiving routine care as many specialties closed or reduced working during the crisis. However, there were also many examples of good practice, positive changes and innovation.
Improving the quality of self-management support in ambulatory cancer care: a mixed-method study of organisational and clinician readiness, barriers and enablers for tailoring of implementation strategies to multisites
Authors: Howell Doris , Powis Melanie , Kirkby Ryan , Amernic Heidi , Moody Lesley , Bryant-Lukosius Denise , O'Brien Mary Ann , Rask Sara , Krzyzanowska Monika 
Published: March 2021

IntroductionImproving the quality of self-management support (SMS) for treatment-related toxicities is a priority in cancer care. Successful implementation of SMS programmes depends on tailoring implementation strategies to organisational readiness factors and barriers/enablers, however, a systematic process for this is lacking. In this formative phase of our implementation-effectiveness trial, Self-Management and Activation to Reduce Treatment-Related Toxicities, we evaluated readiness based on constructs in the Consolidated Framework for Implementation Research (CFIR) and Normalisation Process Theory (NPT) and developed a process for mapping implementation strategies to local contexts.MethodsIn this convergent mixed-method study, surveys and interviews were used to assess readiness and barriers/enablers for SMS among stakeholders in 3 disease site groups at 3 regional cancer centres (RCCs) in Ontario, Canada. Median survey responses were classified as a barrier, enabler or neutral based on a priori cut-off values. Barriers/enablers at each centre were mapped to CFIR and then inputted into the CFIR-Expert Recommendations for Implementing Change Strategy Matching Tool V.1.0 (CFIR-ERIC) to identify centre-specific implementation strategies. Qualitative data were separately analysed and themes mapped to CFIR constructs to provide a deeper understanding of barriers/enablers.ResultsSMS in most of the RCCs was not systematically delivered, yet most stakeholders (n=78; respondent rate=50%) valued SMS. For centre 1, 7 barriers/12 enablers were identified, 14 barriers/9 enablers for centre 2 and 11 barriers/5 enablers for centre 3. Of the total 46 strategies identified, 30 (65%) were common across centres as core implementation strategies and 5 tailored implementation recommendations were identified for centres 1 and 3, and 4 for centre 2.ConclusionsThe CFIR and CFIR-ERIC were valuable tools for tailoring SMS implementation to readiness and barriers/enablers, whereas NPT helped to clarify the clinical work of implementation. Our approach to tailoring of implementation strategies may have relevance for other studies.
The effect of dairy products and non-dairy snacks on food intake, subjective appetite and cortisol levels in children: a randomized control study
Authors: Gheller Brandon J.F. , Li Athena C. , Gheller Mary E. , Armstrong Tove , Vandenboer Erik , Bellissimo Nick , Anini Younes , Hamilton Jill , Nunes Fernando , Mollard Rebecca C. , Anderson G. Harvey , Luhovyy Bohdan L. 
Published: March 2021

Dairy snacks are available in various physical forms and their consumption is linked to improved metabolic health. The objective of this study was to determine the effect of dairy snacks of different physical forms on short-term food intake (FI), subjective appetite, and the stress hormone, cortisol, in children. Following a repeated-measures crossover design, 40 children aged 9–14 years randomly consumed 1 of 5 isoenergetic (180 kcal) snacks per study session. These snacks included solid (potato chips, cookies, and cheese), semi-solid (Greek yogurt), and fluid (2% fat milk) snacks. FI was measured 120 min after snack consumption. Subjective appetite was measured at 0 (immediately before the snack), 15, 30, 45, 60, 90, and 120 min. Salivary cortisol (n = 18) was measured after the Greek yogurt and cookie snacks at 0, 30, 60, 90, and 120 min. FI did not differ between snacks (P = 0.15). The Greek yogurt (P < 0.0001) and cheese (P = 0.0009) snacks reduced average appetite compared with the 2% fat milk snack. Salivary cortisol levels were not affected by snack (P = 0.84). This study demonstrates that dairy snacks are as effective as other popular snacks at influencing subsequent FI. However, solid and semi-solid dairy snacks are more effective at repressing subjective appetite than a fluid dairy snack. Registered at ClinicalTrials.gov (NCT02484625). Novelty: Milk, Greek yogurt and cheese have a similar effect on short-term food intake in children as popular potato chips and cookie snacks. Solid, semi-solid and liquid snacks have a similar effect on short-term food intake in children.
Chaotic motion of scalar particle coupling to Chern–Simons invariant in Kerr black hole spacetime
Authors: Zhou Xuan , Chen Songbai , Jing Jiliang 
Published: March 2021

AbstractWe present firstly the equation of motion for the test scalar particle coupling to the Chern–Simons invariant in Kerr black hole spacetime by the short-wave approximation. We have analyzed the dynamical behaviors of the test coupled particles by applying techniques including Poincaré sections, fast Lyapunov exponent indicator, bifurcation diagram and basins of attraction. It is shown that there exists chaotic phenomenon in the motion of scalar particle interacted with the Chern–Simons invariant in a Kerr black hole spacetime. With the increase of the coupling strength, the motion of the coupled particles for the chosen parameters first undergoes a series of transitions betweens chaotic motion and regular motion and then falls into horizon or escapes to spatial infinity. Thus, the coupling between scalar particle and Chern–Simons invariant yields the richer dynamical behavior of scalar particle in a Kerr black hole spacetime.