bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4+ T-cell-dependent manner.
Authors: Ware Michael , McQuinn Christopher , Zaidi Mohommad , Knochelmann Hannah , Robinson Brian , Herting Cameron , Mace Thomas , Chen Zhengjia , Zhang Chao , Farren Matthew , Ruggieri Amanda , Bowers Jacob , Shakya Reena , III Alton Farris , Young Greg , III William Carson , El-Rayes Bassel , Paulos Chrystal , Lesinski Gregory B. 
Published: June 2021

Abstract
This study aimed to enhance anti-tumor immune responses to pancreatic cancer via antibody-based blockade of interleukin-6 (IL-6) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Mice bearing subcutaneous MT5 or orthotopic KPC-luc pancreatic tumors were treated with antibodies to IL-6, CTLA-4, or the combination. This combination significantly inhibited tumor growth, accompanied by overwhelming T-cell infiltration. Tcell depletion studies unveiled a unique dependence on CD4+ T-cells for anti-tumor activity of this combination therapy. In vivo blockade of CXCR3 prevented orthotopic tumor regression in the presence of the combination treatment, demonstrating an integral role for the CXCR3 axis in mediating efficacy. Increased expression of CXCR3 on tumor infiltrating cells was observed by IHC and by PCR. These data represent the first report of IL-6 and CTLA-4 blockade as a means to regress pancreatic tumors with defined operative mechanisms of efficacy. Given these results, this therapeutic combination has potential for immediate clinical translation.
Central Aortic Cannula Disruption Following Left Atrial Myxoma Excision
Authors: Kashyap Nitin Kumar , Nandy Pritam , Magatapalli Kishan , Sahani Preetam , Dantis Klein 
Published: June 2021

Abstract
Background Central aortic cannulation is used to give oxygenated blood to the patient through a heart-lung machine. Major surgical intraoperative bleeding during cardiac surgery is a dreaded complication, resulting in significant morbidity and mortality. Central Aortic cannula disruption during Cardiopulmonary bypass (CPB) is a rare complication which needs prompt management. Case Presentation We are reporting a case of central aortic cannula disruption during LA myxoma excision in which the Metal tip part of the cannula detached from its body, resulting in massive blood loss. Intraoperative blood salvage technique was used to maintain hemodynamics during surgery.Conclusion Aortic cannula disruption is a rare complication and can be lethal to the patient, if not managed timely. Before cannulation, proper visual inspection of all cannulae by team members is very important to eliminate this type of complication.
Reaction Kinetics of Levulinic Acid Synthesis from Glucose Using Bronsted Acid Catalyst
Authors: Toif Meutia Ermina , Hidayat Muslikhin , Rochmadi Rochmadi , Budiman Arief 
Published: June 2021

Abstract
Glucose is the primary derivative of lignocellulosic biomass, which is abundantly available. Glucose has excellent potential to be converted into valuable compounds such as ethanol, sorbitol, gluconic acid, and levulinic acid (LA). Levulinic acid is a very promising green platform chemical. It is composed of two functional groups, ketone and carboxylate groups which can act as highly reactive electrophiles for nucleophilic attack so it has extensive applications, including fuel additives, raw materials for the pharmaceutical industry, and cosmetics. The reaction kinetics of LA synthesis from glucose using hydrochloric acid catalyst (bronsted acid) were studied in a wide range of operating conditions, i.e., temperature of 140-180 oC, catalyst concentration of 0.5-1.5 M, and initial glucose concentration of 0.1-0.5 M. The highest LA yield is 48.34 %wt at 0.1 M initial glucose concentration, 1 M HCl, and temperature of 180 oC. The experimental results show that the bronsted acid catalyst's reaction pathway consists of glucose decomposition to levoglucosan (LG), conversion of LG to 5-hydroxymethylfurfural (HMF), and rehydration of HMF to LA. The experimental data yields a good fitting by assuming a first-order reaction model.
Rhoifolin Alleviate Alcoholic Liver Disease by Inhibiting the TLR4 / NF-kB Signaling Pathway and Attenuating Oxidative Stress
Authors: Mai Baoyu , Han Ling , Zhong Jiarui , Cao Zelin , Fang Jiaqi , Zhang Xiaoying , Gao Zelin , Xiao Fengxia 
Published: June 2021

Abstract
Alcoholic liver disease (ALD) is caused by long-term excessive consumption of alcohol, which is affected by TLR4 / NF-kB mediated inflammatory response and CYP2E1-mediated oxidative stress effects. Rhoifolin (ROF) is a flavonoid compound in Citrus grandis ‘Tomentosa’, with antioxidant and anti-inflammation effect. However, the action of its effect on ALD has been elucidated yet. In the present study, we investigated ROF’s anti-inflammatory, antioxidant and antiapoptotic action in the treatment of ALD. In established ALD mice, ROF promoted hepatic function through downgrading the amount of aminotransferase, attenuating oxidative stress, and restoring antioxidant balance in hepatic tissue. Additionally, ROF significantly reduced the expression of inflammatory cytokines, such as NF-kB, TNF-a, IL-6, and IL-1b in the mice. In vitro experiments indicated that ROF increased the LO2 cells viability and inhibited cells apoptosis. ROF reversed the expression of CYP2E1, NLRP3, p-p65, p-IkB and TLR4, which were consistent with animal experiment. Overall, ROF can alleviate ethanol-induced liver injury through inhibiting oxidative stress and inflammation, and is a promising compound for ALD treatment.
The Potential Function of KIF17 in Large Yellow Croaker (Larimichthys crocea) Spermatid Remodeling: Molecular Characterization and Expression Pattern During Spermiogenesis
Authors: Wang Jingqian , Liu Zhao , Gao Xinming , Du Chen , Hou Congcong , Tang Daojun , Lou Bao , Shen Weiliang , Zhu Jun-Quan 
Published: June 2021

Abstract
KIF17, which belongs to the kinesin-2 protein family, plays an indispensable role in mammalian spermiogenesis. However, the role of KIF17 in fish spermatid remodeling during spermiogenesis remains poorly understood. Therefore, we aimed to study the role of KIF17 in spermatid remodeling during Larimichthys crocea (L. crocea) spermiogenesis. The kif17 cDNA sequence, 3247 bp in length, was cloned from L. crocea testis, which consisted of a 347 bp 5ʹ-untranslated region (UTR), 413 bp 3ʹ -UTR, and 2487 bp open reading frame. Bioinformatic analyses revealed that KIF17 obtained from L. crocea (Lc-KIF17) exhibited a high sequence identity compared with those from other teleosts and possessed the structural features of other kinesin-2 proteins. Based on structural similarity, we speculate that the role of Lc-KIF17 may be similar to that of KIF17 in other animals. Lc-kif17 mRNA was diffusely expressed in L. crocea tissues and was highly expressed in the testis, especially at stage IV testicular development. Immunofluorescence analysis revealed that Lc-KIF17 signals colocalized with β-tubulin signals and migrated from the perinuclear cytoplasm to the side of the nucleus where the tail forms during spermiogenesis. These findings revealed that KIF17 may be involved in L. crocea spermiogenesis. In particular, KIF17 may participate in spermatid remodeling by interacting with perinuclear microtubules during L. crocea spermiogenesis. Collectively, this study contributes to an improved understanding of the mechanism underlying L. crocea spermiogenesis and provides a basis for further research on L. crocea reproduction and development.
Effect of Induction of Labor on Maternal and Perinatal Outcomes in Low-Risk Singleton Pregnancies: A Retrospective Case-Control Study
Authors: Qinjian Zhang , Siwen Chen , Xia Xu , Huale Zhang , Jianying Yan 
Published: June 2021

Abstract
Background: To investigate the effect of induction of labor on maternal and fetal outcomes. Methods: This retrospective case-control study included 4386 pregnant women with low-risk singleton pregnancies who underwent regular prenatal examination and successful vaginal delivery at ≥41 weeks and 0 days of gestation in Fujian Maternal and Child Health Hospital between January 2014 and December 2018. Clinical data were reviewed according to the mode of labor initiation; the women were divided into an induction of labor group (2007 cases) and a spontaneous onset of labor group (2361 cases). Two-sample independent t-test and χ 2 tests were used to analyze the differences in clinical characteristics such as maternal age and parity between the two groups. Results: The induction of labor group had a significantly longer total duration of labor (9.37±5.37 vs. 8.82±5.13 h; P<0.001), was associated with more postpartum blood loss (219.18±188.32 vs. 199.95±124.69 mL; P=0.01), and had a significantly higher incidence of severe postpartum hemorrhage (PPH) (0.8% [16/2007] vs. 0.33% [8/2361]; P=0.041) than the spontaneous onset of labor group. However, no significant difference was found in the neonatal outcomes. After adjusting for age, induction of labor in nulliparous women was more likely to lead to PPH than spontaneous onset of labor (2.74% [55/2007] vs. 1.65% [39/2361]; odds ratio=1.557; 95% confidence interval: 1.039–2.332; P<0.05]. Conclusion: Induction of labor increases postpartum blood loss, especially in primary parturients, leading to an increased risk of PPH, which may be related to the prolongation of the total duration of labor. Therefore, low-risk nulliparous women should try to avoid induction of labor without medical indications.
BET Protein Inhibition Evidently Enhances Sensitivity to PI3K/mTOR Dual Inhibition in Intrahepatic Cholangiocarcinoma
Authors: Miao Xiaolong , Gong Weihua 
Published: June 2021

Abstract
Background & Aims: Intrahepatic cholangiocarcinoma (ICC), the second most common primary liver cancer, is a fatal malignancy with a poor prognosis. Molecular targeted therapy is a promising treatment strategy. However, resistance to molecular-targeted therapy is inevitable and represents a major clinical challenge. Our objective was to provide a novel and efficient therapeutic strategy in treating primary ICC.Approach & Results: We generated an orthotopic ICC mouse model through hydrodynamic transfection of AKT and YAP into mouse liver. Genetic approaches were applied to study the mechanism that mediated resistance to a PI3K/mTOR dual inhibitor in mediating AKT/YapS127A-driven tumorigenesis. Haematoxylin and eosin staining, immunohistochemistry and immunoblotting were applied to assess the efficacy of ICC combination therapy in vitro and in vivo.Conclusions: We confirmed that mTOR signalling is the most significantly affected pathway in ICC. BEZ235, a novel PI3K/mTOR dual inhibitor, can suppress the proliferation, invasion and colony formation abilities of ICC cells in vitro but cannot effectively inhibit ICC progression in vivo. The inhibition of PI3K/mTOR allowed the upregulation of c-Myc and YAP through the suppression of the phosphorylation of LATS1. This is a novel mechanism that mediates resistance to PI3K/mTOR dual inhibitors. However, BET inhibition by JQ1 downregulates c-Myc and YAP transcription, which could enhance the efficacy of PI3K/mTOR inhibitors. The efficacy results of combination therapy exhibited effective treatment of ICC in vitro and in vivo. Our data further confirmed that the combination of a PI3K/mTOR dual inhibitor and BET inhibition induces M1 polarization and suppresses M2 polarization in macrophages by regulating the expression of HIF-1a.
A Scientometric Introspect of Literary Warrants Published in Annals of Library and Information Studies (ALIS) during the Last Decade
Authors: Esh Manash , Ghosh Saptarshi LIS 
Published: June 2021

Abstract
Scientometric studies are enduring studies that portray an organized visual of messy data. The current study is a scientometric study based on secondary data sets included in Scopus. A corpus of 311 documents published in the journal Annals of Library and Information Studies (ALIS) from 2011 to 2020 was the population of the study. The study focused on several characteristics of the journal, including article distribution, average author per document, average document per year, authorship productivity, collaboration index, country-wise distribution of documents and citation analysis. The study retrieved the most prolific author contributing to this journal with 19 articles. The Council of Scientific and Industrial Research (CSIR) and the University of Delhi were the top literary contributors to the ALIS journal. The University of Kerala got the most citations per document (6.833). The maximum count of author keywords (Scientometrics) used in the journal from 2011 to 2020 was 135.
Salivary Cystatin S in Children With Early Childhood Caries in Comparison With Caries-free Children; Statistical Analysis and Machine Learning
Authors: Koopaie Maryam , Salamati Mahsa , Montazeri Roshanak , Davoudi Mansour , Kolahdooz Sajad 
Published: June 2021

Abstract
Background: Early childhood caries is the most common infectious disease in childhood, with a high prevalence in developing countries. Recognition of the factors affecting early childhood caries and its pathophysiology, allows better control of disease. Cystatin S as one of the salivary proteins, has an important role in pellicle formation, tooth re-mineralization and protection. The aim of the present study is to assess salivary cystatin S levels and demographic data in early childhood caries children in comparison with caries-free ones using statistical analysis and machine learning methods. Methods: A cross-sectional case-control study was undertaken on 20 cases of early childhood caries and 20 caries-free children as a control group. Unstimulated whole saliva samples by suction method was collected. Cystatin S concentrations were determined using human cystatin S ELISA kit. A checklist was collected for each participant about the demographic characteristics, oral health status and dietary habits by interviewing parents. The regression and receiver operating characteristic (ROC) curve analysis was done to evaluate the potential role of cystatin S salivary level and demographic using machine learning and statistical analysis.Results: The mean value of salivary cystatin S concentration in early childhood caries group was 191.55±81.90 (ng/ml) and in caries-free group was 370.06±128.87 (ng/ml). T-test analysis showed that there is a statistically significant difference between early childhood caries and caries-free group in salivary cystatin S level (p: 0.032). Investigation of area under the curve and accuracy of ROC curve revealed that logistic regression model based on the salivary cystatin S levels and birth weight had most and acceptable potential for discriminating of early childhood caries from caries-free controls. After that the machine learning models and finally salivary cystatin S levels had more capability for differentiation of early childhood caries from caries-free controls.Conclusion: Salivary cystatin S in caries-free children was higher than the children with early childhood caries. Therefore, cystatin S protein can be used as a biomarker for early prediction of early childhood caries, furthermore cystatin S is a protective factor against dental caries.
Patient and Health worker experiences on Utilization of Community Client Led ART Delivery Model in South-Western Uganda: A Qualitative Study
Authors: Kintu Timothy Mwanje , Ssewanyana Anna Maria , Kyagambiddwa Tonny , Nampijja Pretty Mariam , Apio Patience Kevin , Kitaka Jessica , Kabakyenga Jerome Kahuma 
Published: June 2021

Abstract
BackgroundIn an effort to accommodate the growing number of stable HIV clients, improve retention in care and reduce health care burden the differentiated service delivery (DSD) models were introduced in 2014. One such model, Community Client Led ART Delivery (CCLAD) was rolled out in Uganda in 2017. The extent of utilization of this model has not been fully studied. The aim of the study was to explore the patient and health worker experiences on the utilization of CCLAD model at Bwizibwera Health Centre IV, south western Uganda.MethodsThis was a descriptive study employing qualitative methods. The study had 68 purposively selected participants who participated in 10 Focus Group Discussions with HIV clients enrolled in CCLAD; 10 in-depth interviews with HIV clients not enrolled in CCLAD and 6 health workers. Key informant interviews were held with the 2 focal persons for DSD. The discussions and interviews were audio recorded, transcribed verbatim and then translated. Both deductive and inductive approaches were employed to analyse the data using in NVivo software. ResultsPatient and health worker experiences in this study were categorized as drivers and barriers to the utilization of the CCLAD model. The main drivers for utilization of this model at different levels were: individual (reduced costs, living positively with HIV, improved patient self-management), community (peer support and contextual factors) and health system (reduced patient congestion at the health centre, caring health workers as well as CCLAD sensitization by health workers). However, significant barriers to the utilization of this community-based model were: individual (personal values and preferences, lack of commitment of CCLAD group members), community (stigma, gender bias) and health system (frequent drug stockouts, certain implementation challenges, fluctuating implementing partner priorities, shortage of trained health workers and insufficient health education by health workers).ConclusionBased on our findings the CCLAD model is meeting the objectives set out by Differentiated Service Delivery for HIV care and treatment. Notwithstanding the benefits, challenges remain which call on the Ministry of Health and other implementing partners to address these hindrances to facilitate the scalability, sustainability and the realisation of the full-range of benefits that the model presents.
Electronic Properties of Orthorhombic, Tetragonal and Monoclinic KDP by First-Principles Calculations
Authors: Xu Xia , Yang Ning , Tang Bin , Liu Qi-Jun 
Published: June 2021

Abstract
The electronic properties of KDP (KH2PO4), in orthorhombic, tetragonal and monoclinic phases, have been investigated by using the generalized gradient approximation (GGA) within density functional theory. The comparison of the calculated band gap of the tetragonal crystal and the experimental results shows that the band gap of this paper is very close to the experimental results. In addition, this work calculates the effective mass of KDP for the first time. The effective mass of electrons in the conduction bands of the orthorhombic phase is greater than that of the tetragonal phase, so the mobility of electrons in the tetragonal phase is higher than that of the orthorhombic phase. The calculated DOS shows that the lower conduction band is composed of the K-3p states, P-3p states and O-2p states. There is a strong hybridization between P and O orbitals.
Acute Macular Neuroretinopathy After COVID-19 Vaccine
Authors: Michel Tony , Stolowy Natacha , Gascon Pierre , Dupessey Florence , Comet Alban , Attia Ruben , David Thierry , Denis Daniele 
Published: June 2021

Abstract
We report the case of a 21-year-old female patient with unilateral acute macular neuroretinopathy (AMN) two days after the administration of the Oxford-AstraZeneca COVID-19 vaccination.
Panel Data Modelling of COVID-19 Infected Cases
Authors: ARUNACHALAM RAJARATHINAM , PAKKIRISAMY TAMILSELVAN 
Published: June 2021

Abstract
Background and Objective: The novel coronavirus pandemic, known as COVID-19, could not have been more predictable; thus, the world encountered health crises and substantial economic crises. This paper analyses the trends in COVID-19 cases in October 2020 in four southern districts of Tamil Nadu state, India, using a panel regression model. Materials and Methods: Panel data on the number of COVID-19-infected cases were collected from daily bulletins published through the official website www.stopcorona.tn.gov.in maintained by the Government of Tamil Nadu state, India. Panel data regression models were employed to study the trends. EViews Ver.11. Software was used to estimate the model and its parameters. Results: In all four districts, the COVID-19-infected case data followed a normal distribution. Maximum numbers of COVID-19-infected cases were registered in Kanniyakumari, followed by Tirunelveli, Thoothukudi and Tenkasi districts. The fewest COVID-19 cases were registered in Tenkasi, followed by Tirunelveli, Thoothukudi and Kanniyakumari districts. A random e2ffects model was found to be an appropriate model to study the trend.Conclusion: The panel data regression model is found to be more appropriate than traditional models. The Hausman test and Wald test confirmed the selection of the random effects model. The Jarque-Bera normality test ensured the normality of the residuals. In all four districts under study, the number of COVID-19 infections showed a decreasing trend at a rate of 1.68% during October 2020.
Clinical Profile And Risk Factors of Cerebral Venous Sinus Thrombosis (CVST) in Sudan
Authors: Ibrahim Etedal Ahmed A , Mohamed Rofiedah Eisa Hassan , Ahmed Khabab Abbasher Hussien Mohamed , Omer Mohammed Eltahier Abdalla 
Published: June 2021

Abstract
Background

Cerebral venous sinus thrombosis (CVST) is relatively uncommon cause of stroke mainly affects young ladies, with a wide spectrum of symptoms severity and prognosis. In this study we aim to study the clinical profile and Risk Factors of CVST among Sudanese patients in Khartoum state hospitals.
Methods

This is an observational cross-sectional multi-center hospital based study which covered 37 participants, in three major hospitals in khartoum, with radiologically confirmed Cerebral Venous Sinus Thrombosis (CVST)
Results

37 patients were included in this study, The mean age of patients was 38.5 ± 13.4 years, with minimum age of 23 years and maximum of 75 years, the largest group (n = 18, 48.6%) were in the range between “26–35” years, regarding gender distribution (n = 8; 21.6%) were males and the majority of patients were female (n = 29; 78.4%), the commonest presenting feature was headache (n = 35; 94.6%), followed by blurring of vision (n = 25; 67.6%), while seizures is a presenting symptom in nearly half of the patients (n = 17; 45.9%), on examination papilloedema was present in 83.8%. In this study 13.8% were pregnant, 31.0% were postpartum, OCPS user account for 27.%, and No risk factor present in 32.4%. regarding the involved sinus Sagittal Venous Sinus and the transverse sinus were the most affected sinuses. Regarding treatment options: “low molecular weight heparin followed with warfarin” was found in 81.1%, followed with heparin only 10.8%, while the new agents NOACs comprised only 8.1%.
Conclusion

The study concluded that Cerebral Venous Sinus Thrombosis is mainly a disease of child-bearing women, although significant proportions of men were affected. Cerebral Venous Sinus Thrombosis presents in a wide variety of signs and symptoms.