bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of intrinsic active sites in ternary CuZnTi catalysts toward low-temperature water gas shift reaction
Authors: Zhang Jian , Yin Pan , Xu Ming , Cui Guoqing , Yu Jun , Liu Ning , Hong Song , Zheng Li Rong , Wei Min 
Published: September 2021

Abstract
In the heterogeneous field, modulation over strong metal-support interactions (SMSI) plays a crucial role in boosting catalytic performance toward interface-sensitive reactions (e.g., water gas shift reaction, WGSR). Herein, a CuZnTi ternary catalyst was prepared via in situ structural topological transformation from CuZnTi-layered double hydroxides precursor (CuZnTi-LDHs). The resulting catalyst Cu/ZnTi-MMO(H350) exhibits an extraordinarily high catalytic activity toward low temperature-WGSR with a reaction rate of 19.7 μmolCO gcat-1 s-1 at 250 °C, among the highest level in Cu-based catalysts. Advanced electron microscope and in situ spectroscopy characterizations verify that Cu nanoparticles (particle size: 7~10 nm) are modified by ZnTi-mixed metal oxides with abundant Cuδ+−Ov−Ti3+ (0<δ<1) interfacial sites. Incorporation of Ti element facilitates the reduction of ZnO to stabilize Cuδ+ species at the interface, which enhances the chemisorption of CO molecule. Simultaneously, neighboring Ov−Ti3+ species significantly promotes the dissociation of H2O molecule. The structure-activity correlation studies based on quasi-in situ XPS, in situ DRIFTS, in situ and operando EXAFS reveal that the interfacial sites (Cuδ+−Ov−Ti3+) serve as the intrinsic active sites of WGS reaction. A combination of in situ characterization techniques and DFT calculations further substantiate that associative mechanism is the predominant reactive path below 200 °C whilst redox mechanism is overwhelming above 250 °C in the presence of Cu/ZnTi-MMO catalyst. This work demonstrates a facile modulation on metal-support interfacial structure via LDHs approach, which paves a way for rational design and preparation of heterogeneous catalysts.
Comparison between the Extraperitoneal Route with the Transperitoneal Route for the Permanent Colostomy: A Meta-Analysis with Rcts and Systematic Review
Authors: Luo Jinlong , Singh Dujanand , Zhang Faqiang , Yang Xinting , Zha Xiaoying , Jiang Huaiwu , Yang Lie , Yang Hua 
Published: September 2021

Abstract
AimTo assess the efficacy of extraperitoneal colostomy(EPC) in the prevention of stoma-related complications.BackgroundTransperitoneal colostomy (TPC) is still a widely used surgical approach. However, TPC has been reported with highly incidence of stoma-related complications, like parastomal hernia, stomal retraction, stomal prolapse.The purpose of EPC is to prevent these complications. But it is still lack of evidence-based basis.Material and methodsMEDLINE, EMBASE, Web of Science, Scopus, MOOSE, Pubmed, Google Scholar, Baidu Scholar, and the Cochrane Library were searched to conduct a systematic review and meta-analysis with RCTs. Revman 5.4 was performed in the meta-analysis.ResultsA total of 5 RCTs were eligible in this study. Compared with TPC, EPC group had lower incidence in Parastomal Hernia (RR, 0.14; 95% CI, 0.04–0.52, P=0.003, I2=0%), Stomal Prolapse (RR, 0.27; 95% CI, 0.08–0.95, P=0.04, I2=0%) and a higher rate of defaecation Sensation (RR, 3.51; 95% CI, 2.47–5.0, P＜0.00001, I2=37%). No statistical difference was observed in Stoma Retraction, Colostomy Construction Time, Stoma Ischemia, and Necrosis.ConclusionAn extraperitoneal colostomy is associated with a lower rate of postoperative complication compared to transperitoneal colostomy. Randomized controlled trial meta-analysis showed better results in permanent colostomy after abdominoperineal resection.
Clinical and Radiological Evaluation of Cage Subsidence Following Oblique Lumbar Interbody Fusion
Authors: Zhao Long , XIE Tianhang , Wang Xiandi , Yang Zhiqiang , Pu Xingxiao , Lu Yufei , Zeng Jiancheng 
Published: September 2021

Abstract
Background

Cage subsidence was previously reported as one of the most common complications following oblique lumbar interbody fusion (OLIF). We aimed to assess the impacts of CS on surgical results following OLIF, and determine its radiological characteristics and related risk factors.
Methods

Two hundred and forty-two patients underwent OLIF at L4-5 and with a minimum 12 months follow-up were reviewed. Patients were divided into three groups according to the extent disk height (DH) decrease during the follow-up: no CS (DH decrease ≤ 2 mm), mild CS (2mm < DH decrease ≤ 4 mm) and severe CS (DH decrease > 4mm). The clinical and radiological results were compared between groups to evaluate the radiological features, clinical effects and risk factors of CS.
Results

CS was identified in 79 (32.6%) patients, including 48 (19.8%) with mild CS and 31 (11.8%) with severe CS. CS mainly identified within 1 month postoperatively and did not progress after 3 months postoperatively, and more noted in the caudal endplate (44, 55.7%). In terms of clinical results, patients in the mild CS group were significantly worse than those in the no CS group, and patients in the severe CS group were significantly worse than those in the mild CS group. There was no significant difference in fusion rate between no CS (92.6%, 151/163) and mild CS (83.3%, 40/48) groups. However, significant lower fusion rate was observed in severe CS group (64.5%, 20/31) compared to no CS group. CS related risk factors included osteoporosis (OR = 5.976), DH overdistraction (OR = 1.175), flat disk space (OR = 3.309) and endplate injury (OR = 6.135).
Conclusion

CS following OLIF was an early postoperative complication. Higher magnitudes of CS were associated with worse clinical improvements and lower intervertebral fusion. Osteoporosis and endplate injury were significant risk factor for CS. Additionally, flat disk space and DH overdistraction were also correlated with the increased probability of CS.
COVID-19 and Autoimmunity: A Single Center Prospective Follow-Up Study
Authors: Sacchi Maria Cristina , Tamiazzo Stefania , Bonometti Ramona , Stobbione Paolo , Agatea Lisa , De Gaspari Piera , Lauritano Enrico Cristiano , Ciriello Maria Matilde , Maconi Antonio 
Published: September 2021

Abstract
Background: Various factors, such as viral infections, can act as triggers for the development of autoimmune diseases.In our recent study we reported the presence of autoantibodies in patients diagnosed with COVID-19. To verify whether these autoantibodies persisted over time and led to the development of chronic autoimmune diseases, we conducted a follow-up study at 3 and 6 months after admission.Methods:Thirteen of 40 patients enrolled in the previous study gave their consent to the analysis. The same autoimmunity tests performed at the time of diagnosis were carried out in these patients during follow up.Results:We showed, compatibly with an acute inflammatory response, that two patients were negative 6 months after diagnosis. In nine patients, autoantibodies were still present at follow-up. Among them, one patient had only ENA positivity. Another patient developed strong positivity for ANA and M2-β and Ku antigens. Currently, the symptoms do not meet full diagnostic criteria for diagnosis of polymyositis, but the patient is closely monitored to check its possible onset.Three patients developed: transient alopecia, autoimmune thrombocytopenia and hearing loss. Other four patients did not show any clinical symptoms.Conclusions:In conclusion, our data show that after 6 months, the autoantibodies are still present in the majority of patients. Further investigations will be necessary to check whether these patients will become negative over time or may develop clinical symptoms compatible with the onset of longer-term chronic autoimmune diseases.
Prognostic impact of hypochromic erythrocytes in patients with pulmonary arterial hypertension
Authors: Xanthouli Panagiota , Theobald Vivienne , Benjamin Nicola , Marra Alberto Maria , D'Agostino Anna , Egenlauf Benjamin , Shaukat Memoona , Ding Cao , Cittadini Antonio , Bossone Eduardo , Kögler Maria , Grünig Ekkehard , Muckenthaler Martina , Eichstaedt Christina Alessandra 
Published: September 2021

Abstract
Background

Iron deficiency affects up to 50% of patients with pulmonary arterial hypertension (PAH) but iron markers such as ferritin and serum iron are confounded by several non-disease related factors like acute inflammation and diet. The aim of this study was to identify a new marker for iron deficiency and clinical outcome in PAH patients.
Methods

In this single-center, retrospective study we assessed indicators of iron status and clinical parameters specifying the time to clinical worsening (TTCW) and survival in PAH patients at time of initial diagnosis and at 1-year follow-up using univariable and multivariable analysis.
Results

In total, 150 patients were included with an invasively confirmed PAH and complete data on iron metabolism. The proportion of hypochromic erythrocytes > 2% at initial diagnosis was identified as an independent predictor for a shorter TTCW (p = 0.0001) and worse survival (p = 0.002) at initial diagnosis as well as worse survival (p = 0.016) at 1-year follow-up. Only a subset of these patients (64%) suffered from iron deficiency. Low ferritin or low serum iron neither correlated with TTCW nor survival. Only severe hemoglobin deficiency at baseline was significantly associated with a shorter TTCW (p = 0.001).
Conclusions

The presence of hypochromic erythrocytes > 2% was a strong and independent predictor of mortality and shorter TTCW in this cohort of PAH patients. Thus, it can serve as a valuable indicator of iron homeostasis and prognosis even in patients without iron deficiency or anemia. Further studies are needed to confirm the results and to investigate therapeutic implications.
Transcriptome Changes Associated with Boron Applications in Fruits of Watercore-susceptible Pear Cultivar
Authors: Liu Xiao , Liu Dong-He , Shen Yan , Liu Jing , Wei Jun , Wang Chunlei 
Published: September 2021

Abstract
Watercore is a common physiological disorder in pear and is closely related to excessive accumulation of sorbitol and sucrose. Our previous research found the watercore incidence of ‘Akibae’ (Pyrus pyrifolia cv. Akibae) fruit significantly decreased after boron application (BA). Moreover, foliar spray of boric acid also significantly improved fruit quality. To uncover the mechanisms underlying pear fruit response to BA, a comprehensive transcriptome analysis was performed in this study. Transcriptome results revealed a total of 3146 up-regulated and 1145 down-regulated differently expressed genes (DEGs) between control and treated fruits of ‘Akibae’ pear, respectively. BA significantly induced expression of sorbitol metabolism and sucrose metabolism genes. Besides, BA also increased the expression of starch degradation, fatty acid synthesis, IAA (indole-3-acetic acid) degradation, GA (gibberellin acid) synthesis and inhibit the expression of ethylene synthesis genes. Overall, these findings suggested that BA alleviated ‘Akibae’ watercore occurrence and improve fruit quality by regulating the decrease of sorbitol and sucrose, increased of fatty acid and a balance of plant hormone. Our results provided further information for understanding the molecular mechanism of the effect of boron application on pear fruit.
The Effect of Metformin When Combined With Neoadjuvant Chemotherapy in Breast Cancer Patients
Authors: El-Khayat Shaimaa , Abouegylah Mohamed , Abdallah Dina , Geweil Ahmed Gaber , Elenbaby A.M. , Zahra Omar Shebl 
Published: September 2021

Abstract
BackgroundMetformin has been used to treat type 2 Diabetes Mellitus since long time. It has two proposed anti-neoplastic mechanisms, direct (insulin-independent) and indirect (insulin-dependent) actions. PurposeTo assess the effect of Metformin on pathological response when combined with neoadjuvant chemotherapy in breast cancer. Material and MethodsA prospective study included stage II, III non-diabetic breast cancer patients who received neoadjuvant chemotherapy in our center during the period from May 2017 to March 2019. 59 patients met our inclusion criteria and completed the study, 27 patients received 850mg Metformin every 12 hrs with chemotherapy (group A), 32 patients received chemotherapy without Metformin (group B). Pathological response was assessed by Chevallier classification and residual cancer burden score (RCB). ResultsBoth groups were well balanced regarding base line characteristics. The results of our study showed that the rate of pathological complete response (pCR) was 14.8% in group (A) vs. 6.3% in group (B) with a P-value of 0.39. RCB class 3 was 40.7% in group (A) Vs. 68.8% in group (B) which was statistically significant with a (P-value of 0.031). Patients with triple-positive histology who had RCB class 3 were only (14.3%) in group (A) versus (60%) in group B. Patients with body mass index (BMI) ≥25 who had RCB 3 were 40% and 66.7% in group (A) and (B) respectively. ConclusionMetformin may increase the pCR especially in patients with BMI≥25 and patients with triple-positive histology, a larger phase III study is needed to confirm this finding.
Identification of Immune-related lncRNA Panel for Predicting Immune Checkpoint Blockade and Prognosis in Head and Neck Squamous Cell Carcinoma
Authors: Zhou Chongchang , Zhan Guowen , Shen Zhisen , Shen Yi , Deng Hongxia , Shen Yiming , Wang Jianing , Li Jinyun 
Published: September 2021

Abstract
Immunotherapy is changing head and neck squamous cell carcinoma (HNSCC) treatment pattern. According to the Chinese Society of Clinical Oncology (CSCO) guidelines, immunotherapy has been deemed as first-line recommendation for recurrent/metastatic HNSCC, marking that advanced HNSCC has officially entered the era of immunotherapy. Long non-coding RNAs impact every step of cancer immunity. Therefore, reliable immune-lncRNA able to accurately predict the immune landscape and survival of HNSCC are crucial to clinical management. In the current study, we downloaded the transcriptomic and clinical data of HNSCC from The Cancer Genome Altas and identified differentially expressed immune-related lncRNAs (DEir-lncRNAs). Further then, Cox and least absolute shrinkage and selection operator (LASSO) regression analyses were performed to identify proper DEir-lncRNAs to construct optimal risk model. Low-risk and high-risk groups were classified based on the optimal cut-off value generated by the areas under curve for receiver operating characteristic curves (AUC), and Kaplan-Meier survival curves were utilized to validate the prediction model. We then evaluated the model based on the clinical factors, immune cell infiltration, chemotherapeutic and immunotherapeutic efficacy between two groups. Our results constructed a risk model consisted of 18 DEir-lncRNA pairs showing significantly association with survival of patients with HNSCC. Besides, HNSCC patients with low risk score significantly enriched of CD8+ T cell, and corelated with high chemosensitivity and immunotherapeutic sensitivity. In summary, our risk model could be served as a promising clinical prediction indicator, effective discoursing of the immune cell infiltration of HNSCC patients, and distinguishing patients who could benefit from chemotherapy and immunotherapy.
Design, Synthesis and Biological Evaluation of C-8 Modified Curcumol Derivatives as Potential Anticancer Agents
Authors: Meng Xiangwei , Wei Yingying , Nong Binglu , Zhao Huajun , Zhang xingxian 
Published: September 2021

Abstract
A series of structural modification of curcumol derivatives at C-8 position were designed and synthesized, which structures were confirmed by 1H NMR,13C NMR and HRMS analysis. The tested compounds were evaluated for in vitro antitumor activity against colorectal cancer cell lines SW620, HCT116 and CaCo2. Many of the tested candidates exhibited higher inhibition efficiency than curcumol. Among them, compound 3l shows the best inhibitory effect on the viability of SW620 with IC50 value of 19.90 mM. The structure-activity relationships (SARs) of these derivatives were discussed, which showed that the introduction of amino or aryl groups tended to increase the anti-cancer activity. In addition, compound 3l may inhibit cancer cell proliferation through triggering cell apoptosis.
A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues
Authors: Glaser Adam , Bishop Kevin , Barner Lindsey , Susaki Etsuo , Kubota Shimpei , Gao Gan , Serafin Robert , Balaram Pooja , Turschak Emily , Nicovich Philip , Lai Hoyin , Lucas Luciano , Yi Yating , Nichols Eva , Huang Hongyi , Reder Nicholas , Wilson Jasmine , Sivakumar Ramya , Shamskhou Elya , Stoltzfus Caleb , Wei Xing , Hempton Andrew , Pende Marko , Murawala Prayag , Dodt Hans , Imaizumi Takato , Shendure Jay , Beliveau Brian , Gerner Michael , Xin Li , Zhao Hu , True Lawrence , Reid R. Clay , Chandrashekar Jayaram , Ueda Hiroki , Svoboda Karel , Liu Jonathan 
Published: September 2021

Abstract
Light-sheet microscopy has emerged as the preferred means for high-throughput volumetric imaging of cleared tissues. However, there is a need for a user-friendly system that can address imaging applications with varied requirements in terms of resolution (mesoscopic to sub-micrometer), sample geometry (size, shape, and number), and compatibility with tissue-clearing protocols and sample holders of various refractive indices. We present a ‘hybrid’ system that combines a novel non-orthogonal dual-objective and conventional (orthogonal) open-top light-sheet architecture for versatile multi-scale volumetric imaging.
Independent prediction of aspartate aminotransferase to alanine aminotransferase ratio for adverse outcomes of patients with pyogenic liver abscess
Authors: Dai Huifang , Pan Youjin , Xu Jing 
Published: September 2021

Abstract
Background: In viral hepatitis, an increase in the ratio of aspartate aminotransferase to alanine aminotransferase (AAR) is associated with poor prognosis. However, the relationship between AAR and pyogenic liver abscess (PLA) remains to be unclear. In this study, the relationship between AAR and adverse outcomes in PLA patients were explored, and the predictive value of AAR were evaluated. Methods: In total, 240 PLA patients were consecutively enrolled in this study and followed up at 3 months. Univariate analysis, receiver-operating characteristic (ROC) curve analysis and multivariate logistic regression analyses were performed. Results: According to the ROC curve of AAR for adverse outcomes, the patients were divided into two groups using a cutoff of 0.97. Patients with high AAR had higher risk of mortality rate (16.5% vs 2.9%), empyema (23.7% vs 10.4%), metastatic infection (19.1% vs 9.7%), acute myocardial (7.3% vs 0.7%), acute hepatic failure (7.3% vs 2.2%) and septic shock (13.7% vs 4.4%) than patients with low AAR (all P<0.05). after adjusting for potential confounding factors in our logistic model, high AAR was independently associated with death (odds ratio (OR)=6.17, 95% of confidence interval (CI)=1.88-20.26) and all adverse outcomes (OR=4.03, 95% CI=2.12-7.66). AAR had the largest area under ROC curve (AUC) than ALT, AST in all adverse outcomes (AUC=0.690, cutoff value=0.97, P<0.01) and death prediction (AUC=0.821, cutoff value=1.31, P<0.01). Conclusion: In the clinical application of PLA, AAR may be a good method to predict the prognosis.
Detection of mild cognitive impairment by spinal posture assessment in health exams of the general older population: A Japanese cohort survey randomly sampled from a basic resident registry
Authors: Nishimura Hikaru , Ikegami Shota , Uehara Masashi , Takahashi Jun , Tokida Ryosuke , Kato Hiroyuki 
Published: September 2021

Abstract
The recent increase in the older adult population has led to a higher prevalence of cognitive impairment, which is often overlooked in routine health examinations. Citizens aged 50 to 89 years were targeted for this cohort survey by random sampling from the resident registry of a cooperating town in 2014. A total of 413 participants (203 male and 210 female) were enrolled. We analyzed the distribution of cognitive function test scores as determined by Montreal Cognitive Assessment and Mini-Mental State Examination tests in each age (50’s, 60’s, 70’s and 80’s) and sex group to examine whether mild cognitive impairment (MCI) could be detected by sagittal spinal balance measurement based on a radiological approach. Sagittal spinal balance was quantitatively measured as sagittal vertical axis (SVA). We observed significant associations for higher age and/or SVA anteriorization with lower cognitive function. In men, spinal balance anteriorization was associated with MCI independently of age, with combinations of age and SVA also making valid MCI determinations; male cases of SVA ≥ 100 mm at any age, SVA ≥ 90 mm at ≥ 70 years, and SVA ≥ 70 mm at ≥ 80 years were all more likely to have MCI than cases below those values. For women, MCI was more likely in cases of SVA ≥ 70 mm, regardless of age. Thus, spinal balance anteriorization can be regarded as an easily visible indicator of latent MCI in community-dwelling older people.
Gap-Filling of Ocean Color Over the Tropical Indian Ocean Using Monte-Carlo Method
Authors: Modi A , K Roxy M , S Ghosh 
Published: September 2021

Abstract
Continuous remote-sensed daily fields of ocean color now span over two decades; however, it still remains a challenge to examine the ocean ecosystem processes, e.g., phenology, at temporal frequencies of less than a month. This is due to the presence of significantly large gaps in satellite data caused by clouds, sun-glint, and hardware failure; thus, making gap-filling a prerequisite. Commonly used techniques of gap-filling are limited to single value imputation, thus ignoring the error estimates. Though convenient for datasets with fewer missing pixels, these techniques introduce potential biases in datasets having a higher percentage of gaps, such as in the tropical Indian Ocean during the summer monsoon, the satellite coverage is reduced up to 40% due to the seasonally varying cloud cover. In this study, we fill the missing values in the tropical Indian Ocean with a set of plausible values (here, 10,000) using the classical Monte-Carlo method and prepare 10,000 gap-filled datasets of ocean color. Contrary to the previously used gap-filled datasets, the ecological indicators derived using our gap-filled datasets also quantifies uncertainty indicating the likelihood of estimates. Quantification of uncertainty is critical to address the importance of underlying datasets and hence, motivating future observations.