bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global epidemiology of acromegaly: a systematic review and meta-analysis
Authors: Crisafulli Salvatore , Luxi Nicoletta , Sultana Janet , Fontana Andrea , Spagnolo Federica , Giuffrida Giuseppe , Ferraù Francesco , Gianfrilli Daniele , Cozzolino Alessia , Cristina De Martino Maria , Gatto Federico , Barone-Adesi Francesco , Cannavò Salvatore , Trifirò Gianluca 
Published: June 2021

Objective
To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in the literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the identified studies.

Methods
MEDLINE, EMBASE and The Cochrane Library databases were searched for studies assessing the epidemiology of acromegaly from inception until 31 January 2020. We included original observational studies written in English, reporting acromegaly prevalence and/or incidence for a well-defined geographic area. Two reviewers independently extracted data and performed quality assessments. Prevalence and incidence pooled estimates were derived by performing a random-effects meta-analysis.

Results
A total of 32 studies were included in the systematic review, and 22 of them were included in the meta-analysis. The pooled prevalence of acromegaly was 5.9 (95% CI: 4.4–7.9) per 100 000 persons, while the incidence rate (IR) was 0.38 (95% CI: 0.32–0.44) cases per 100 000 person-years. For both prevalence and IR, considerable between-study heterogeneity was found (I2 = 99.3 and 86.0%, respectively). The quality of study reporting was rated as the medium for 20 studies and low for 12 studies.

Conclusions
Although the largest amount of heterogeneity was due to the high precision of the studies’ estimates, data source and geographic area could represent relevant study-level factors which could explain about 50% of the total between-study variability. Large-scale high-quality studies on the epidemiology of acromegaly are warranted to help the public health system in making decisions.
Persistent improvement of bone mineral density up to 20 years after treatment of Cushing’s syndrome
Authors: van Houten Pepijn , Netea-Maier Romana , Wagenmakers Margreet , Roerink Sean , Hermus Ad , van de Ven Annenienke 
Published: June 2021

Objective
Cushing’s syndrome (CS) is associated with osteoporosis and high fracture risk. Besides male sex, it is unknown which variables influence bone mineral density (BMD) at diagnosis and it is unclear to what extent BMD normalizes during long-term follow-up after treatment of CS. The aim of this study was to determine factors associated with BMD at diagnosis of CS and to determine the long-term course of BMD and fracture rate after successful treatment of CS.

Design
Retrospective cross-sectional and longitudinal cohort study.

Methods
Data were collected from 231 patients with CS who were treated at the Radboud University Medical Centre between 1968 and 2020.

Results
At diagnosis, male sex was associated with lower Z-scores at the lumbar spine (LS) compared with female sex: −0.97s.d. (−1.45 to −0.49) after correction for possible confounders. Shorter duration of symptoms and younger age were also associated with lower Z-scores at diagnosis, while etiology of CS, urinary cortisol excretion and gonadal status were not associated with Z-scores at diagnosis. Z-scores improved up to 20 years after treatment. Fifteen years after treatment, men showed larger improvements of Z-scores than women; +2.56 (1.82–3.30) increase in LS Z-score vs +1.48 (0.96–2.00) respectively. Fracture incidence was highest during the 2 years before diagnosis and decreased after treatment.

Conclusion
Male sex, younger age and shorter duration of symptoms are associated with lower BMD at diagnosis of CS. BMD continues to improve up to 20 years after treatment of CS. Fracture rate decreases after treatment of CS.
El contacto y la comunicación en la pandemia
Authors: Chaves Ignacio 
Published: June 2021

El ser humano es un animal social y físico que se construye desde y por el cuerpo. Es porque los demás son y le hacen ser; y se “alimenta” del contacto con sus congéneres. Parte de ese “contacto” es la comunicación por la que establece relaciones sociales con otras personas.
La sociabilidad es un tema de contacto y de comunicación, o viceversa; porque por la comunicación mantenemos el contacto con los otros y el contacto es una manera de comunicarnos. ¿Cómo han sido la comunicación y el contacto durante la pandemia? Parece que hemos entrado en un museo virtual en el que nuestros acercamientos se han visto constreñidos a las conexiones a través de las pantallas.
Reflexionar alrededor de la comunicación y el contacto en estos inciertos tiempos pandémicos es necesario para saber qué lugar ocupan y cómo se están viendo afectadas y cuáles están siendo sus repercusiones en las relaciones sociales. El futuro dependerá en gran parte de cómo nos enfrentemos comunicacional y afectivamente a la “nueva” situación surgida de esta metamorfosis social que estamos sufriendo.
One Call Away: Addressing a Safety Gap for Urgent Issues Post Discharge
Authors: Yale Sarah , Bauer Sarah Corey , Stephany Alyssa , Porada Kelsey , Liljestrom Tracey 
Published: June 2021

OBJECTIVES:The transition period from hospitalization to outpatient care can be high risk for pediatric patients. Our aim was to profile the use of a “safety net” for families through provision of specific inpatient provider contact information for urgent issues post discharge.METHODS:In this prospective study, we implemented an updated after-visit summary that directed families to call the hospital operator and specifically ask for the pediatric hospital medicine attending on call if they were unable to reach their primary care provider (PCP) with an urgent postdischarge concern. Education for nursing staff, operators, and pediatric hospital medicine providers was completed, and contact information was automatically populated into the after-visit summary. Information collected included the number of calls, the topic, time spent, whether the family contacted the PCP first, and the time of day. Descriptive statistics and Fisher’s exact test were used to summarize findings.RESULTS:Over a 13-month period, of 5145 discharges, there were 47 postdischarge phone calls, which averaged to 3.6 calls per month. The average length of time spent on a call was 21 minutes. For 30% of calls, families had tried contacting their PCPs first, and 55% of calls occurred at night. Topics of calls included requesting advice about symptoms, time line for reevaluation, and assistance with medications.CONCLUSIONS:This safety net provided families with real-time problem-solving for an urgent need post discharge, which included triaging patient symptoms at home, counseling on medication questions, information about the time line of illness recovery, and provision of additional resources.
Letting Residents Lead: Implementing Resident Admission Triage Call Curriculum and Practice
Authors: Bauer Sarah Corey , McFadden Vanessa , Madhani Kavi , Kaeppler Caitlin , Porada Kelsey , Weisgerber Michael C. 
Published: June 2021

BACKGROUND AND OBJECTIVES:
Graduating residents are expected to be competent in triaging patients to appropriate resources. Before 2017, pediatric residents were not involved in admission triage decisions. In 2017, after implementing an admission triage curriculum (ATC), residents had opportunities to be involved in overnight admission calls with the emergency department (ED), which were initially supervised (joint calls), and as skills progressed, residents conducted calls and admitted patients independently. We implemented and evaluated the impact of a graduated ATC intervention bundle on pediatric resident opportunities to participate in admission triage, while monitoring resident confidence, the ED experience, and patient safety.

METHODS:
We evaluated the impact of our ATC using quality improvement methodology. The primary outcome was the frequency of resident participation in joint and independent triage calls. Other measures included resident confidence, the ED clinician experience, and patient safety. Resident confidence and the ED clinician experience were rated via surveys. Safety was monitored with daytime hospitalist morning assessments and postadmission complications documented in the medical record.

RESULTS:
The percent of joint calls with the hospitalist increased from 7% to 88%, and 125 patients were admitted independently. Residents reported significant increases in adequacy of triage training and confidence in 3 triage skills (P &lt; .001) after ATC. There were no complications or safety concerns on patients admitted by residents. ED clinicians reported increased admitting process efficiency and satisfaction.

CONCLUSIONS:
Our ATC intervention bundle increased the number of admission decision opportunities for pediatric residents, while increasing resident triage confidence, maintaining safety, and improving ED clinician experience.
Outcomes Associated With High- Versus Low-Frequency Laboratory Testing Among Hospitalized Children
Authors: Stephens John R. , Hall Matt , Markham Jessica L. , Tchou Michael J. , Cotter Jillian M. , Shah Samir S. , Steiner Michael J. , Gay James C. 
Published: June 2021

BACKGROUND AND OBJECTIVES:Previous pediatric studies have revealed substantial variation in laboratory testing for specific conditions, but clinical outcomes associated with high- versus low-frequency testing are unclear. We hypothesized that hospitals with high- versus low-testing frequency would have worse clinical outcomes.METHODS:We conducted a multicenter retrospective cohort study of patients 0 to 18 years old with low-acuity hospitalizations in the years 2018–2019 for 1 of 10 common All Patient Refined Diagnosis Related Groups. We identified hospitals with high-, moderate-, and low-frequency testing for 3 common groups of laboratory tests: complete blood cell count, basic chemistry studies, and inflammatory markers. Outcomes included length of stay, 7- and 30-day emergency department revisit and readmission rates, and hospital costs, comparing hospitals with high- versus low-frequency testing.RESULTS:We identified 132 391 study encounters across 44 hospitals. Laboratory testing frequency varied by hospital and condition. We identified hospitals with high- (13), moderate- (20), and low-frequency (11) laboratory testing. When we compared hospitals with high- versus low-frequency testing, there were no differences in adjusted hospital costs (rate ratio 0.89; 95% confidence interval 0.71–1.12), length of stay (rate ratio 0.98; 95% confidence interval 0.91–1.06), 7-day (odds ratio 0.99; 95% confidence interval 0.81–1.21) or 30-day (odds ratio 1.01; 95% confidence interval 0.82–1.25) emergency department revisit rates, or 7-day (odds ratio 0.84; 95% confidence interval 0.65–1.25) or 30-day (odds ratio 0.91; 95% confidence interval 0.76–1.09) readmission rates.CONCLUSIONS:In a multicenter study of children hospitalized for common low-acuity conditions, laboratory testing frequency varied widely across hospitals, without substantial differences in outcomes. Our results suggest opportunities to reduce laboratory overuse across conditions and children’s hospitals.
DEVELOPMENT OF JAPONICA TYPE CYTOPLASMIC MALE STERILE (CMS) RICE LINES FOR COMMERCIAL HYBRID RICE IN MEDITERRANEAN ECOLOGICAL CONDITION
Authors: UNAN Rasim 
Published: June 2021

Hybrid rice has an average
15 % to 20 % yield advantage over inbred lines. The availability of stable cytoplasmic male sterility
system is vital for commercial hybrid rice. The experiment was conducted to
develop japonica type CMS lines of national rice varieties. National varieties
were tested to determine as maintainer, CMS or restorer features via test
cross. The test crosses were made by using 19 japonica type national rice varieties
and 21 CMS lines and 1 restorer line. All national rice varieties which tested are
determined maintainer features. In addition to, 5 CMS introduction lines and 1
restorer lines adapted Mediterranean ecological condition for hybrid breeding
process. Two maintainer were backcrossed for 6 generations and it was developed
similar agronomic features and 100% spikelet sterile CMS lines. For production
of CMS lines Osmancik-97 and Kiziltan, it was employed wild abortive rice which
is CMS V20A. Successive backcrossing of varieties succeeded to produce
completely male sterile CMS lines. Wild abortive cytoplasm did not affect
agronomic characteristic. Since Osmancik-97 is one of the most popular
varieties and it was used as a donor gene for new varieties, the WA-CMS lines
of Osmancik-97 and Kiziltan will be useful for hybrid rice breeding.
Síndrome cri du chat: un maullido del gato
Authors: Quesada Zaragoza Natalia 
Published: June 2021

El síndrome del maullido de gato es una enfermedad hereditaria rara que se caracteriza por el hecho de que el niño afectado, bebé lactante, tiene un llanto similar al maullido de un gato (grito de un gato = cri du chat). El síndrome del maullido de gato está causado por una alteración específica del material genético: la pérdida (deleción) de una parte de las estructuras filiformes del núcleo celular que portan el material genético (uno de los brazos de uno de los cromosomas: el brazo corto del cromosoma 5).
El maullido de gato puede caracterizarse por alteraciones físicas y psicomotoras ya que se ralentizan. Suelen tener un peso extremadamente bajo tras el parto. El apoyo físico y mental temprano es decisivo para estos niños. La voz de los niños con síndrome del maullido de gato suele diferenciarse más a medida que crecen y el desarrollo del lenguaje suele retrasarse considerablemente.
PENGEMBANGAN TADRIBAT PEMBELAJARAN ISTIMA’ BUKU AL ‘ARABIYAH LIL HAYAH BERBASIS ONLINE
Authors: Ubaid Abdullah , Maghfur Taaib 
Published: June 2021

The development of online-based Arabic learning media is a requirement in this modern era to improve the quality of learning. The purpose of this research is (1) to produce an exercise of online-based listening learning in Al 'Arabiyah Lil Hayah Book. (2) Analyzing the feasibility of online listening learning exercises in the Al 'Arabiyah Lil Hayah Book.This study uses a research and development model according to Borg and Gall with 10 stages, namely: (1) research and information collecting, (2) planning, (3) develop preliminary form of product, (4) preliminary field testing, (5) main product revision (6) main field testing, (7) operasional product revision, (8) operasional field testing, (9) final product revision, (10) dissemination and implementation.The output of this research and development is an exercise of online-based listening learning in Al 'Arabiyah Lil Hayah Book which can be accessed by users very easily via a computer or smartphone connected to an internet network without having to download certain applications, but simply typing the website address ppb.uin-malang.ac.id/alh in the user's device browser.Based on the results of the research that has been carried out by the researcher, it can be concluded that the exercise of online-based listening learning in Al 'Arabiyah Lil Hayah Book is feasible to use. This refers to the data obtained by researchers from the results of the questionnaire analysis by the Arabic learning media experts, namely Dr. Danial Hilmi, M.Pd. as well as respondents from PKPBA students in the preliminary field testing, main field testing and operasional field testing.
Prevalence of Nutritional Risk at Admission in Internal Medicine Wards in Portugal: The Multicentre Cross-Sectional ANUMEDI Study
Authors: Marinho Ricardo , Pessoa Ana , Lopes Marta , Rosinhas João , Pinho João , Silveira Joana , Amado Ana , Silva Sandra , Oliveira Bruno , Marinho Anibal , Jager-Wittenaar Harriët 
Published: June 2021

Introduction: Disease-related undernutrition is highly prevalent and requires timely intervention. However, identifying undernutrition often relies on physician judgment. As Internal Medicine wards are the backbone of the hospital setting, insight into the prevalence of nutritional risk in this population is essential. We aimed to determine the prevalence of nutritional risk in Internal Medicine wards, to identify its correlates, and to assess the agreement between the physicians’ impression of nutritional risk and evaluation by Nutritional Risk Screening 2002.Material and Methods: A cross-sectional multicentre study was performed in Internal Medicine wards of 24 Portuguese hospitals during 2017. Data on demographics, previous hospital admissions, primary diagnosis, and Charlson comorbidity index score were collected. Nutritional risk at admission was assessed using Nutritional Risk Screening 2002. Agreement between physicians’ impression of nutritional risk and Nutritional Risk Screening 2002 was tested by Cohen’s kappa.Results: The study included 729 participants (mean age 74 ± 14.6 years, 51% male). The main reason for admission was respiratory disease. Mean Charlson comorbidity index score was 5.8 ± 2.8. Prevalence of nutritional risk was 51%. Nutritional risk was associated with admission during the previous year (odds ratio = 1.65, 95% confidence interval: 1.22 - 2.24), solid tumour with metastasis (odds ratio = 4.73, 95% confidence interval: 2.06 - 10.87), any tumour without metastasis (odds ratio = 2.04, 95% confidence interval:1.24 - 3.34), kidney disease (odds ratio = 1.83, 95% confidence interval: 1.21 - 2.75), peptic ulcer (odds ratio = 2.17, 95% confidence interval: 1.10 - 4.25), heart failure (odds ratio = 1.51, 95% confidence interval: 1.11 - 2.04), dementia (odds ratio = 3.02, 95% confidence interval: 1.96 - 4.64), and cerebrovascular disease (odds ratio = 1.62, 95% confidence interval: 1.12 - 2.35). Agreement between physicians’ evaluation of nutritional status and Nutritional Risk Screening 2002 was weak (Cohen’s kappa = 0.415, p < 0.001).Discussion: Prevalence of nutritional risk in the Internal Medicine population is very high. Admission during the previous year and multiple comorbidities increase the odds of being at-risk. Subjective physician evaluation is not appropriate for nutritional screening.Conclusion: The high prevalence of at-risk patients and poor subjective physician evaluation suggest the need to implement mandatory nutritional screening.
L'entrée des Croisés à Constantinople
Authors: Chimot Jean-Philippe 
Published: June 2021

Inquiet de son avenir, le gouvernement de la Monarchie de Juillet (1830-48) invente une sorte de roman national en peinture, à Versailles notamment. Il en attend une légitimation indirecte. Dans l'épisode des Croisades (12°et 13° siècles), réévalué et chanté par le romantisme, Delacroix reçoit une commande : l'Entrée des Croisés à Constantinople (1204), livrée en 1840. On analyse ici comment, d'un épisode peu glorieux (en fait un pillage), il développe, par sa poétique plastique et chromatique, toutes les sombres et éclatantes contradictions.
Profil Keterampilan Merancang Rencana Pelaksanaan Pembelajaran Blended Learning Guru Fisika
Authors: Ismet Ismet , Wiyono Ketang , Andriani Nely , Saparini Saparini , Novaliza Anggia , Rizaldi Widya Rahmatika 
Published: June 2021

Kegiatan pendampingan penyusunan rencana pelaksanaan pembelajaran (RPP) blended learning bagi guru Fisika MGMP Ogan Ilir bertujuan meningkatkan keterampilan guru menyusun rencana pembelajaran berbasis daring. Kegiatan dikemas dalam konsep penelitian tindakan kelas yang dilaksanakan sebanyak 3 siklus. Siklus I membahas materi rencana pembelajaran blended learning menggunakan zoom meeting. Siklus 2 pembimbingan secara online dan tugas mandiri secara asinkronis. Siklus 3 pembimbingan secara kolaboratif dengan menggunakan zoom meeting dan pada tahapan akhir dilaksanakan seminar hasil kegiatan. Teknik pengumpulan data teknik nontes. Instrumen pengumpulan data menggunakan lembar observasi yang dilaksanakan secara asinkronis. Data yang terkumpul berbentuk RPP blended learning dan kemudian diobservasi sesuai indikator kelengkapan RPP. Teknik analisa menggunakan deksriptif dengan menentukan presentase. Hasil pengabdian menunjukkan adanya peningkatan keterampilan guru dalam membuat RPP hal ini ditunjukkan dengan persentase sebesar 94%. Dapat disimpulkan terdapat peningkatan keterampilan Guru MGMP Fisika Ogan Ilir dalam menyusun Rencana Pembelajaran Blended Learning pada mata pelajaran Fisika. Assistance activities have been carried out to prepare Blended learning implementation plans for Physics teacher MGMP Ogan Ilir. This activity aims to improve the skills of teachers in preparing online-based learning plans. Activities are packaged in the concept of classroom action research which is carried out in 3 cycles. Cycle I discusses the material of the blended learning plan using zoom meetings. Cycle 2 online guidance and asynchronous independent assignment. Cycle 3 Collaborative guidance using zoom meetings, and in the final stage, a seminar on the results of the activities are held. Non-test technique data collection techniques. The data collection instrument used an observation sheet which was carried out asynchronously and synchronously through a zoom meeting. The analysis technique uses a percentage, and then it is described. The results showed an increase in the skills of teachers in making lesson plans, which was indicated by the percentage of validity of 94%. It can be concluded that there is an increase in the skills of the Physics MGMP Teachers of Ogan Ilir in compiling Blended Learning Plans on Physics subjects.