bluuebunny/crossref_metadata_2025_split huggingface dataset:
A denouement of defiance and death: Escaping the liminal space and phase of a Japanese internment camp in Ismail Marahimin's And the War is Over
Authors: Arps Arnoud 
Published: December 2024

AbstractIncreasingly, the importance of Indonesian perspectives is emphasized for the understanding of the Dutch colonial past. In this article, I examine the work of Indonesian author Ismail Marahimin. His only novel, Dan Perang Pun Usai (And the War Is Over), was published in 1977 and is set in the latter days of the Japanese occupation of Indonesia. What is remarkable about the story is not only the diversity of characters, but especially how they are each connected to a Japanese internment camp in Sumatra. This article shows how the idea of “liminality,” or a period and space of uncertainty and transition, recurs in the novel in various ways, not least for the Dutch internees, who are preparing an escape. This focus lays bare how liminal spaces and liminal phases produce fundamental changes for the actors involved, but also how they produce changes in how we culturally remember the past.
Insights on Wet and Dry Workflows for Human Gut Metaproteomics
Authors: Marzano Valeria , Levi Mortera Stefano , Putignani Lorenza 
Published: December 2024

ABSTRACTThe human gut microbiota (GM) is a community of microorganisms that resides in the gastrointestinal (GI) tract. Recognized as a critical element of human health, the functions of the GM extend beyond GI well‐being to influence overall systemic health and susceptibility to disease. Among the other omic sciences, metaproteomics highlights additional facets that make it a highly valuable discipline in the study of GM. Indeed, it allows the protein inventory of complex microbial communities. Proteins with associated taxonomic membership and function are identified and quantified from their constituent peptides by liquid chromatography coupled to mass spectrometry analyses and by querying specific databases (DBs). The aim of this review was to compile comprehensive information on metaproteomic studies of the human GM, with a focus on the bacterial component, to assist newcomers in understanding the methods and types of research conducted in this field. The review outlines key steps in a metaproteomic‐based study, such as protein extraction, DB selection, and bioinformatic workflow. The importance of standardization is emphasized. In addition, a list of previously published studies is provided as hints for researchers interested in investigating the role of GM in health and disease states.
As‐Needed Inhaled Corticosteroid‐Formoterol in a Single Inhaler Compared to Inhaled Corticosteroid‐Albuterol in Separate Inhalers as Reliever Therapy in Mild Pediatric Asthma: A Cost‐Utility Analysis
Authors: Rodríguez‐Martínez Carlos E. , Sossa‐Briceño Monica P. , Buendia Jefferson Antonio 
Published: December 2024

ABSTRACTObjectivesSince 2019 as‐needed low‐dose ICS‐formoterol in a single inhaler has been recommended for treatment of mild asthma in children aged more than 12 years. Alternatively, the use of ICS‐albuterol has been proposed in countries where ICS‐formoterol is not available or affordable. The aim of the present study was to evaluate the cost‐utility of as‐needed ICS‐albuterol in separate inhalers compared to ICS‐formoterol in a single inhaler as reliever therapy in pediatric patients with mild asthma living in Colombia.MethodsA Markov‐type model was developed to estimate the costs and health outcomes of a simulated cohort of pediatric patients with mild asthma treated for 12 months. The effectiveness data and transition probabilities were obtained from relevant randomized clinical trials (RCTs). Cost data were obtained from official databases provided by the Colombian Ministry of Health. The main outcome was the variable “quality‐adjusted life‐years” (QALYs).ResultsThe base‐case analysis showed that compared with the use of as‐needed ICS‐albuterol in separate inhalers, the use of ICS‐formoterol in a single in pediatric patients with mild asthma was associated with lower costs (US$475.51 vs. 735.33 average cost per patient) and the greatest gain in QALYs (0.9367 vs. 0.9352 QALYs on average per patient), thus leading to dominance.ConclusionsCompared with the use of as‐needed ICS‐albuterol in separate inhalers, the use of ICS‐formoterol in a single inhaler as reliever therapy is cost‐effective in patients aged 12 years or more with mild asthma, because it showed a greater gain in QALYs at lower total treatment costs.
An Efficient Approach to the Design and Construction of Novel Energetic Materials: Co‐Crystallization and Chemical Reaction of Insensitive Explosive ICM‐102 in Acidic Solutions
Authors: Wang Fei , Zhao Yunshu , Zhou Xu , Sun Shanhu , Li Siyao , Su Li , Zhang Xiaoyan , Liu Yonggang , Suo Zhirong , Xu Jinjiang , Sun Jie 
Published: December 2024

AbstractThe cocrystal represents a practical method for developing new energetic materials. However, insensitive explosives (LLM‐105, TATB, ICM‐102) encounter challenges in forming cocrystal explosives with other molecules due to the dense hydrogen bond interactions in insensitive explosives. To facilitate the formation of cocrystal explosives based on insensitive explosives, the electron distribution of typical insensitive explosives was analyzed by surface electrostatic potential (ESP), revealing that the ICM‐102 molecule exhibits strong proton affinity. Through the cultivation of a single crystal found that ICM‐102 undergoes self‐assembly and chemical reactions in acid, resulting in the efficient construction of two energetic cocrystals and two energetic salts. First, ICM‐102 undergoes supramolecular self‐assembly with HCOOH (MA) and CH3COOH (HAc) to generate the energetic cocrystals HG‐1 and HG‐2. Notably, HG‐1 is a ternary cocrystal. Second, ICM‐102 participates in hydrolysis and salt formation reactions in HF and HCl to form energetic salts Salt‐1 and Salt‐2. This study efficiently obtained the cocrystal explosives based on ICM‐102, providing a solid theoretical foundation for the construction of cocrystal explosives based on insensitive explosives.
Catocene and Butacene Permanence as Ferrocenic Liquid Burning Rate Catalyst for Solid Composite Propellants and Comparison With Recent Developments
Authors: Amado Javier Quagliano , Dutra Rita C. L. , Dutra Jorge C. N. , Ross Pablo 
Published: December 2024

ABSTRACTA short review about ferrocene‐based burning rate catalysts (FBRC) for solid composite propellants is presented. Historically, transition metal oxides (TMO) have been utilized as burning rate catalysts (BRC) since the start of solid rocket propellant development. However, these compounds have a marked tendency to migrate through the propellant grain and crystallize at boundary surfaces. Consequently, FBRC emerged as an alternative to TMO. After reviewing recent advances in the field, we suggest that the continued use of Catocene [2,2′‐bis(ethylferrocenyl)propane] and Butacene as liquid BRC of choice is based on a trade‐off between high burning rates, limited migration from propellant, simpler synthetic pathways, and lower costs of production in comparison with later developments in the area of FBRC. Then, this work aims to contribute to the state of the art of FBRC research, highlighting the importance of Catocene and Butacene, in comparison with the most recent developments in the field of FBRC, particularly regarding their role in decreasing the decomposition temperature of ammonium perchlorate and/or increasing the burning rate.
Thermal Research on the Decomposition Behaviors and Interactional Mechanism of NC–NG With DNTF
Authors: Huang Meng , Zhou Jing , Wang Xiaofeng , Zhang Junlin , Zheng Wei , Pan Qing 
Published: December 2024

ABSTRACTThe thermal decomposition analysis of nitrocellulose–nitroglycerine (NC–NG), 3,4‐dinitrofurazanfuroxan (DNTF), and their mixed system with differential scanning calorimetry (DSC), thermogravimetric analysis‐DSC–mass spectroscopy–Fourier transform infrared spectroscopy (TG–DSC–MS–FTIR) coupling technique, and in situ FTIR experiments under different experimental conditions was carried out for the investigation of interaction mechanism between NC–NG and DNTF. The results demonstrated that the NC–NG mixture significantly decreased the decomposition peak temperature of DNTF, and the activation energy of final mixed system (156.32 kJ mol−1) was lower than both NC–NG (163.82 kJ mol−1) and DNTF (177.03 kJ mol−1). On the basis of the gas fragmental products and condensed phase changes, NC–NG triggered the thermally decomposition process, resulting intensive amount of nitrogen oxides which further caused the breakage of nitro groups in DNTF.
A crucial active site network of titratable residues guides catalysis and NAD+ binding in human succinic semialdehyde dehydrogenase
Authors: Cesaro Samuele , Orlando Marco , Bettin Ilaria , Longo Carmen , Spagnoli Giulia , de Laureto Patrizia Polverino , Molla Gianluca , Bertoldi Mariarita 
Published: December 2024

AbstractHuman succinic semialdehyde dehydrogenase is a mitochondrial enzyme fundamental in the neurotransmitter γ‐aminobutyric acid catabolism. It catalyzes the NAD+‐dependent oxidative degradation of its derivative, succinic semialdehyde, to succinic acid. Mutations in its gene lead to an inherited neurometabolic rare disease, succinic semialdehyde dehydrogenase deficiency, characterized by mental and developmental delay. Due to the poor characterization of this enzyme, we carried out evolutionary and kinetic investigations to contribute to its functional behavior, a prerequisite to interpreting pathogenic variants. An in silico analysis shows that succinic semialdehyde dehydrogenases belong to two families, one human‐like and the other of bacterial origin, differing in the oligomeric state and in a network of active site residues. This information is coupled to the biophysical–biochemical characterization of the human recombinant enzyme uncovering that (i) catalysis proceeds by an ordered bi–bi mechanism with NAD+ binding before the aldehyde that exerts a partial non‐competitive inhibition; (ii) a stabilizing complex between the catalytic Cys340 and NAD+ is observed and interpreted as a protective mechanism; and (iii) a concerted non‐covalent network assists the action of the catalytic residues Cys340 and Glu306. Through mutational analyses of Lys214, Glu306, Cys340, and Glu515 associated with pH studies, we showed that NAD+ binding is controlled by the dyad Lys214‐Glu515. Moreover, catalysis is assured by proton transfer exerted by the same dyad networked with the catalytic Glu306, involved in catalytic Cys340 deprotonation/reprotonation. The identification of this weak bond network essential for cofactor binding and catalysis represents a first step to tackling the molecular basis for its deficiency.
Role of Mutual Information Profile Shifts in Assessing the Pathogenicity of Mutations on Protein Functions: The Case of Pyrin Variants Associated With Familial Mediterranean Fever
Authors: Hacisuleyman Aysima , Gul Ahmet , Erman Burak 
Published: December 2024

ABSTRACTThis study presents a novel method to assess the pathogenicity of pyrin protein mutations by using mutual information (MI) as a measure to quantify the correlation between residue motions or fluctuations and associated changes affecting the phenotype. The concept of MI profile shift is presented to quantify changes in MI upon mutation, revealing insights into residue–residue interactions at critical positions. We apply this method to the pyrin protein variants, which are associated with an autosomal recessively inherited disease called familial Mediterranean fever (FMF) since the available tools do not help predict the pathogenicity of the most penetrant variants. We demonstrate the utility of MI profile shifts in assessing the effects of mutations on protein stability, function, and disease phenotype. The importance of MI shifts, particularly the negative shifts observed in the pyrin example, as indicators of severe functional effects is emphasized. Additionally, the exploration of potential compensatory mechanisms suggested by positive MI shifts, which are otherwise random and inconsequential, is highlighted. The study also discusses challenges in relating MI profile changes to disease severity and advocates for comprehensive analysis considering genetic, environmental, and stochastic factors. Overall, this study provides insights into the molecular mechanisms underlying the pathogenesis of FMF and offers a framework for identifying potential therapeutic targets based on MI profile changes induced by mutations.
Alanine to glycine substitution in the PyR2 confers sodium channel resistance to Type I pyrethroids
Authors: Chen Mengli , Wang Likui , Zhou Xiangyi , Chen Guoxing , Xu Zhanyi , Yan Ru , Qian Jiali , Zhu Guonian , Wu Shaoying , Wu Huiming 
Published: December 2024

AbstractBACKGROUNDAedes aegypti is a primary urban vector of dengue, yellow fever, Zika and chikungunya worldwide. Pyrethroid insecticides are the most effective insecticides for controlling Ae. aegypti. However, pyrethroid resistance has developed due to the long‐term overuse of the insecticides, and many knockdown resistance (kdr) mutations have been identified in the resistant populations. A1007G, an alanine to glycine substitution, was found in resistant Ae. aegypti from Vietnam and Malaysia, which has always co‐existed with F1534C and V1016G. However, the role of A1007G in pyrethroid resistance and the linkage of A1007G and F1534C or V1016G remain unknown.RESULTSIn this study, we examined the effects of mutations on the sodium channel gating properties and pyrethroid sensitivity in Xenopus oocytes. We found mutations A1007G, A1007G + F1534C and A1007G + V1016G + F1534C shifted the voltage dependence of activation in the depolarizing direction. Mutations A1007G + F1534C and A1007G + V1016G + F1534C shifted the voltage dependence of inactivation in the depolarizing direction. Both mutations A1007G and F1534C reduced the channel sensitivity to two Type I pyrethroids, permethrin and bifenthrin, and synergistic effects were observed between mutations A1007G and F1534C. However, none of the mutations, A1007G, F1534C and A1007G + F1534C affected the channel sensitivity to two Type II pyrethroids, deltamethrin and cypermethrin. Furthermore, triple mutations A1007G + V1016G + F1534C significantly reduced the channel sensitivity to both Type I and Type II pyrethroids.CONCLUSIONWe identified A1007G had a distinct effect on sodium channel sensitivity to Type I, but not to Type II pyrethroids, also A1007G exhibited synergistic effects with F1534C to Type I pyrethroids, which will provide a fundamental insight into the distinct molecular interactions between insect sodium channel and Type I or Type II pyrethroids. © 2024 Society of Chemical Industry.
Parameter Estimate and Adaptive Control of DARMA Systems With Uniform Quantized Output Data
Authors: Jing Lida 
Published: December 2024

ABSTRACTThis paper is concerned with parameter estimate and adaptive control problems of deterministic autoregressive moving average (DARMA) systems on the basis of quantized data of system output signals which are generated by a kind of uniform quantizer. By designing system input signals, the extended least‐squares (ELS) algorithm with uniform output observations is proved to yield bounded estimation errors under some mild assumptions. Moreover, the adaptive tracking controller under inaccuracy observations is also designed. To analyse the properties of tracking error, we use the expanded form of the ELS and research the boundedness of quantization noise. In addition, we give the expression of tracking error and show how it depends on the size of quantization step when the quantization step satisfies some conditions. A numerical example is supplied to demonstrate the theoretical results.
A High‐Order Fully Actuated System Approach for Prescribed Performance Tracking Control of Quadrotor Unmanned Aerial Vehicle With Time‐Varying Uncertain Aerodynamic Parameters and Disturbances
Authors: Chen Yang , Zhang Dandan , Zhang Zhikai , Zhang Heng 
Published: December 2024

ABSTRACTIn this paper, a high‐order, fully actuated (HOFA) system approach‐based adaptive control design, with guaranteed transient and steady‐state tracking performances, is proposed for trajectory tracking of a lightweight, low‐cost quadrotor unmanned aerial vehicle (QUAV). Unlike most existing results on adaptive control for QUAVs, we consider the aerodynamic parameters and disturbance terms of the QUAV model as time‐varying uncertainties. These uncertainties are only assumed to be bounded, with no additional restrictions imposed on their bounds and derivatives, making our approach more suitable for QUAVs in dynamic harsh environments. Moreover, in contrast to the existing first‐order state‐space model‐based methods such as typical adaptive backstepping designs, the proposed HOFA system‐based approach does not require multiple design steps and can achieve arbitrarily assignable eigenstructure like a stabilized linear system, which makes the control design very simple and easy to implement for practical applications. In addition, by introducing the prescribed performance control technique and incorporating a novel appointed‐time performance function, it is shown that all tracking errors can be steered into their predesignated precision regions within their respective pre‐appointed settling times. Finally, the effectiveness and advantages of the proposed method are validated through simulation.
Design and Synthesis of New Quinoxaline‐Oxazole‐Morpholino Conjugates; Evaluation of Anticancer Activity and In Silico Molecular Docking and ADMET Studies
Authors: Bonakolluru Yellaiah , Marupati Siddhartha , Kandala Satyanarayana , Dasari Gouthami , Manchal Ravinder , Bandari Srinivas 
Published: December 2024

AbstractIn this paper, we report the synthesis of targeted quinoxaline‐oxazole‐morpholino conjugates (5a–n) in a conventional three‐step procedure from 3‐chloroquinoxalin‐2(1H)‐one. The anticancer activity was assessed against two human cancer cell lines, including MCF‐7 (breast) and HepG2 (liver), using the MTT assay method. In this study, Erlotinib was used as the standard drug. The anticancer activity results show that the compounds 5g (MCF‐7 = 1.20 ± 0.10 and HepG2 = 1.04 ± 0.05 µM), 5f (MCF‐7 = 1.29 ± 0.10 and HepG2 = 1.10 ± 0.06 µM), and 5e (MCF‐7 = 1.72 ± 0.10 and HepG2 = 1.45 ± 0.12 µM) exhibited more potent anticancer activity as compared to the standard drug Erlotinib. In a cell survivability test (MCF‐10A), all the three potent compounds (5g, 5f, and 5e) were evaluated against the normal breast cell line, although neither of them displayed any significant cytotoxicity with IC50 values greater than 88 .02 µM. In addition to this, molecular docking studies of compounds 5g, 5f, and 5e demonstrated that these compounds had more EGFR‐binding interactions. The potent compounds were further screened for their in vitro tyrosine kinase EGFR inhibitory activity using Erlotinib as the reference drug. The two compounds, 5g and 5f, display the highest tyrosine kinase EGFR inhibitory potency than the reference Erlotinib. The active compounds 5g, 5f, and 5e were subjected to in silico pharmacokinetic assessment by SWISS, ADME, and pkCSM. The three compounds, 5g, 5f, and 5e, followed Lipinski, Veber, Egan, and Muegge rules without any deviation.
Study on the Influence of Coupling Polycondensation of Coal Liquefaction Residue and Biomass to Produce Carbon Materials
Authors: Luo Huafeng , Gao Long , Qin Zhizhen , Wei Zheng 
Published: December 2024

AbstractThe coal liquefaction residue has been extensively used in the synthesis of various carbon materials. They still exist low density and strength. To improve these properties, a method of preparing high density and strength carbon materials by coupling coal liquefaction residue with biomass is proposed. Three kinds of biomass are added to the coal liquefaction residue, to attain the purpose of preparing carbon materials. The results show that different biomasses have a greater impact on the pyrolysis of coal liquefaction residue, and there is a synergistic effect between both. The maximum pyrolysis rate shifts to the low temperature segment. The different biomass can promote the increase of coal liquefaction residue polymerization yield, and the maximum growth rate is 7.52% compared with single pyrolysis. The density of carbides made from diverse biomass and coal liquefaction residues have increased significantly, the structure is denser, the whole is “rock”, and the maximum density is 1.98 g/cm3, which has reached the industrial metallurgical coke standard. The microcrystalline structure of carbides is arranged regularly and tends to graphitization. The different biomass can narrow the sulfur content of polymers and carbides, and the minimum sulfur content is 1.33%.
Carboxymethyl Chitosan‐based Biodegradable Films Preparation and Prospects for Food Preservation
Authors: Pk. Md. Elius Hosen , Islam Md. Monarul , Akter Rabeya , Nesa Fajilatun , Rahman Mohammad Mahbubur , Paul Trisha , Mustafi Sonjida , Karim Md. Rezaul , Rahman Shofiur , Alodhayb Abdullah N. , Vasquez‐Guardado Erick S. , Albrithen Hamad 
Published: December 2024

AbstractIn this study, carboxymethyl chitosan (CMCS)‐based biodegradable films were prepared by blending with polyvinyl alcohol (PVA) in water and characterized for their potential application as innovative food packaging materials. Blends of CMCS and PVA polymer solutions were cast and dried at 50 °C for 48 hours to obtain a flexible and transparent film. The films were prepared at different composition and were characterized using various techniques including Fourier‐transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), tensile strength (TS), scanning electron microscopy (SEM), and Thermogravimetric analysis (TG). The FTIR analysis confirmed the successful incorporation of carboxymethyl groups into the chitosan molecules, indicating the modification of chitosan. XRD pattern indicates an amorphous phase of the CMCS films. SEM images of the film surfaces show a uniform structure containing no cracks or holes revealing that both PVA and CMCS had good compatibility and unique film‐forming ability. The CMCS/PVA films demonstrated superior performance compared to conventional synthetic packaging materials, with a low water vapor transmission rate (53.46 g/m2/h), good tensile strength (10.8 MPa), and elongation at break (20.36%). Practical application tests showed that coating green chilies with CMCS/PVA films reduced water loss by 20% compared to uncoated chilies, effectively enhancing their shelf life.
The Sub‐Acute Potential Risk of Oxamyl in Male Albino Rats
Authors: Salama Maher S. , Osman Khaled A. , Elbanna Rania 
Published: December 2024

ABSTRACTThe current study aimed to investigate the sub‐acute effects of oxamyl on male Albino rats following oral administration of either 0.031 or 0.31 mg/kg/day for 14 consecutive days. The findings demonstrated that oxamyl produced a significant impact on most of the examined blood profile and biomarkers, along with a significant progressive and discernible alterations in the histology of organs. According to the results obtained, the potential mechanisms by which oxamyl causes its toxic effects on rats are identified as the inflammation indices, the inhibition of transaminases, alkaline phosphatase, and antioxidant enzymes, as well as the production of thiobarbituric acid reactive substances (TBARs) in organs following oxamyl treatment based on histopathological examinations. Due to the substantial genetic similarities between rats and humans, it is therefore anticipated that oxamyl will have comparable detrimental effects on humans.