bluuebunny/crossref_metadata_2025_split huggingface dataset:
KCNQ5 and C9orf50 Methylation in Stool DNA for Early Detection of Colorectal Cancer
Authors: Cao Yaping , Zhao Guodong , Yuan Mufa , Liu Xiaoyu , Ma Yong , Cao Yang , Miao Bei , Zhao Shuyan , Li Danning , Xiong Shangmin , Zheng Minxue , Fei Sujuan 
Published: January 2021

BackgroundAberrant DNA methylation has emerged as a class of promising biomarkers for early colorectal cancer (CRC) detection, but the performance of methylated C9orf50 and methylated KCNQ5 in stool DNA has never been evaluated.MethodsMethylation specific quantitative PCR (qPCR) assays for methylated C9orf50 and methylated KCNQ5 were developed. The methylation levels of C9orf50 and KCNQ5 in 198 CRC patients, 20 advanced adenoma (AA) patients, 101 small polyp (SP) patients, and 141 no evidence of disease (NED) subjects were analyzed.ResultsThe methylation levels of both KCNQ5 and C9orf50 genes were significantly higher in CRC and AA groups than those in SP and NED groups, but showed no significant difference among different stages of CRC. The sensitivities of methylated KCNQ5 and methylated C9orf50 for CRC detection were 77.3% (95% CI: 70.7–82.8%) and 85.9% (95% CI: 80.0–90.2%) with specificities of 91.5% (95% CI: 85.3–95.3%) and 95.0% (95% CI: 89.7–97.8%), respectively. When C9orf50 and methylated KCNQ5 were combined, the clinical performance for CRC detection was similar to that of methylated C9orf50 alone.ConclusionsStool DNA based methylated C9orf50 test has the potential to become an alternative approach for CRC screening and prevention.
A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza®) in Healthy Male Subjects
Authors: Mai Gang , Fan Lianlian , Li Mupeng , Zhang Peiwen , Gan Chunyan , Huang Qian , Shentu Jianzhong 
Published: January 2021

Objective: Pharmacokinetic (PK) similarity between biosimilar candidate LRG201902 and European Union-sourced liraglutide reference product (Victoza®) was evaluated. Safety and immunogenicity were also assessed.Methods: This single-dose, randomized, open-label, 2-period crossover study (CTR20192342) was conducted in thirty-eight healthy adult male subjects. Volunteers were randomized 1:1 at the beginning to receive a single 0.6 mg dose of Victoza® or LRG201902 by subcutaneous injection during the first period. Following 8 days washout period, all subjects received the alternate formulation during the second period. Blood samples were collected up to 72 h after administration. The primary pharmacokinetic endpoints were AUC0–t, AUC0–∞, and Cmax. Pharmacokinetic similarity was achieved if 90% confidence intervals (CIs) of the geometric mean ratios (GMRs) of AUC0-t, AUC0–∞, and Cmax were within the range of 80–125%. Other pharmacokinetic parameters including Tmax, t½, and λz were also measured. Safety profile and immunogenicity data were collected from each subject.Results: Cmax, AUC0–t, and AUC0–∞ were similar between the two groups. GMRs of Cmax, AUC0–t, and AUC0–∞ were 113.50%, 107.21%, and 106.97% between LRG201902 and Victoza® respectively. The 90% CIs for the GMRs of Cmax, AUC0-t, and AUC0–∞ were all within the PK equivalence criteria. Mean serum concentration-time profiles, secondary pharmacokinetic parameters (Tmax, t½, and λz) were comparable between groups. Treatment-related adverse events were reported by 27.8% and 23.7% subjects in the LRG201902 and Victoza® arms, respectively. All post-dose samples were detected negative for anti-drug antibodies.Conclusion: This study demonstrates pharmacokinetic similarity of LRG201902 to Victoza® in healthy subjects. The safety and immunogenicity profiles were similar for the two products.
As metodologias ativas aplicadas ao trabalho crítico da habilidade oral em Português como língua adicional
Authors: Leroy Henrique Rodrigues , Santos Camila de Souza , Maria Mamani Silvana , Paula Milena Maria Ferreira de Paula , Bernardes Anna Karolina Sousa 
Published: January 2021

Esta pesquisa qualitativa de caráter descritivo e exploratório analisa uma unidade didática de Português Língua Adicional (PLA) de nível intermediário, focada no trabalho com as habilidades orais nesse idioma. Os objetivos deste estudo são: verificar a aplicação ou não das Metodologias Ativas nas tarefas de produção e compreensão oral em língua adicional e verificar se há mobilização de estratégias para a formação crítica do aluno na preparação para a oralidade examinada pelo Celpe-Bras. Os conceitos basilares deste estudo são as Metodologias Ativas (FILATRO e CAVALCANTI, 2018; MORÁN, 2017; BERBEL, 2011) e os aspectos da oralidade no ensino-aprendizagem do PLA (MARCUSCHI, 2003). As análises demonstram que a unidade mobiliza diversas estratégias para potencializar a compreensão e a produção oral com protagonismo do estudante, abrindo espaço ao diálogo sobre a diversidade cultural e explorando a criticidade através das Metodologias Ativas.
The Influence Of Transformational Leadership, Personal Value And Organizational Commitment To The Performance Of Millerial Employees In Digital Era In Companies Internet Services Provider (Isp) In City Batam With Motivation As An Intervening Variable
Authors: Nurhatisyah Nurhatisyah , Rumengan Jemmy , Satriawan Bambang , Yanti Sri , Fahizah Ana , Dewi Nolla Puspita 
Published: January 2021

This study aims to analyze the effect of transformational leadership, personal value, and organizational commitment on the performance of millennial employees with motivation as an intervening variable on millennial employees of internet service provider companies in Batam. This type of research is associative causality. This research was conducted using a survey method by distributing questionnaires. The population of this research is three internet service provider companies domiciled in Batam Center. Data analysis methods used are descriptive statistical analysis and Partial Least Square (SEM-PLS) analysis. The analysis was assisted with the Smart PLS 3.0 program. The results of this study indicate that transformational leadership and organizational commitment significantly influence the performance of millennial employees of internet service provider companies in Batam while personal value has no significant effect. transformational leadership has no significant effect on motivation, while personal values and organizational commitment have a significant effect on motivation. The transformational leadership, personal value, and organizational commitment indirectly have insignificant effect on the performance of millennial employees of internet service provider companies in Batam with motivation as an intervening variable. transformational leadership has no significant effect on motivation, while personal values and organizational commitment have a significant effect on motivation. The transformational leadership, personal value, and organizational commitment indirectly have insignificant effect on the performance of millennial employees of internet service provider companies in Batam with motivation as an intervening variable. transformational leadership has no significant effect on motivation, while personal values and organizational commitment have a significant effect on motivation. The transformational leadership, personal value, and organizational commitment indirectly have insignificant effect on the performance of millennial employees of internet service provider companies in Batam with motivation as an intervening variable.
UJI GABUNGAN PERTUMBUHAN JARAK PAGAR AKIBAT PEMBERIAN FMA DAN SITOKININ DI DUA LOKASI BERBEDA
Authors: Indriana Kovertina Rakhmi 
Published: January 2021

Tujuan penelitian ini untuk mengungkapkan hasil pertumbuhan tanaman terbaik melalui uji gabungan multi lokasi dengan memberikan kombinasi tiga kultivar jarak pagar dan dosis fungi mikoriza arbuskular (FMA) terbaik dengan konsentrasi sitokinin pada lahan marginal seperti tanah inceptisol. Percobaan dimulai bulan Januari 2019 sampai bulan Juni 2019 pada ketinggian 0-50 mdpl (dataran rendah) dan ketinggian 750-850 mdpl (dataran menengah). Percobaan kombinasi mengevaluasi kultivar jarak pagar dengan dosis FMA terbaik dan konsentrasi sitokinin diulang 3 kali. Hasil percobaan terdapat pengaruh yang nyata dan interaksi antara sitokinin dan kultivar jarak pagar dengan dosis FMA terbaik maka dapat ditentukan kombinasi terbaik antara sitokinin dan kultivar jarak pagar dengan dosis FMA terbaik di kedua lokasi yaitu pada konsentrasi sitokinin 100 mg L-1 untuk rata-rata laju asimilasi bersih (LAB), konsentrasi sitokinin 300 mg L-1 untuk luas daun, nisbah luas daun, dan nisbah pupus akar. Serta konsentrasi sitokinin 400 mg L-1 untuk rata-rata laju tumbuh (LTR).
PENGARUH KEPEMIMPINAN DAN MOTIVASI TERHADAP PARTISIPASI ANGGOTA DI MASYARAKAT PELESTARI PADI PANDANWANGI CIANJUR (MP3C)
Authors: Alam Asep Saepul , Rizal Ahmad Nur , Rohmatulloh Dany 
Published: January 2021

Dalam organisasi, pemimpin dan anggota sangat berperan penting untuk menjalankan sebuah organisasi. Sifat kepemimpinan yang dimiliki oleh seorang pemimpin sangat penting untuk mengarahkan anggotanya agar bisa mencapai tujuan organisasi bersama-sama, selain seorang pemimpin, komponen penting dalam organisasi adalah anggota, motivasi yang dimiliki oleh anggota akan berperan pada organisasi untuk tercapainya visi dan misi organisasi. Sehingga kedunya penyebab tersebut akan mempengarhi partisipasi anggota dalam mengikuti kegiatan di dalam organisasi Penelitian ini bertujuan untuk mengetahui pengaruh baik secara simultan ataupun parsial antara kepemimpinan dan motivasi terhadap partisipasi anggota di Masyarakat Pelestari Padi Pandanwangi Cianjur (MP3C). Penelitian ini menggunakan path analisis. Hasil penelitian menunjukan: (1) terdapat pengaruh antara kepemimpinan terhadap partisipasi anggota, (2) terdapat pengaruh antara motivasi terhadap partisipasi anggota, (3) terdapat pengaruh antara kepemimpinan dan motivasi terhadap partisipasi.
The evaluation of Avian Influenza and Coronavirus as Human Pathogenic Enveloped Viruses for Possible Health Risk in Seafood: A Review
Authors: TOKUR Bahar , KORKMAZ Koray 
Published: January 2021

Human pathogenic viruses in seafood are a significant and emerging problem for public health, food safety, and socio-economic implications worldwide. They may exist in any form of untreated water due to pollution induced by fecal content of human or animal origin, directly infected through interaction with body secretions and fluids containing contagious viral particles, or indirectly by aerosols or other polluted fomites. Thus, human pathogenic viruses can cause infection anytime by transmitting them from water and food environments to seafood and its products. Nowadays, people go through an unprecedented, huge challenge and global health disaster around the world because of the severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) outbreak. Non-enveloped viruses are commonly known to have more stable and can survive much longer than viruses with an envelope tag. However, some studies show that some enveloped viruses such as avian influenza can be accumulated by seafood and can survive at low temperature for a long time. Low temperature preservation of seafood during processing, storage, transfer, distribution and display in retail stores are common methods to prevent the loss of quality and survival of the SARS-CoV2 may be enough time to have all transmission routes at these low temperatures like other viruses. However, there have been no cases of COVID-19 infection identified through either water-borne or food-borne transmission since the beginning of the pandemic (almost a year). It seems that the main way of virus transmission is mostly person to person through respiratory droplets. So, it is thought to be that the risk of getting COVID-19 from seafood is very low and it can safely consume with proper cooking and hygiene protocol.
Fragilización por hidrógeno y Brush Plating
Authors: Sepúlveda Orlando , Monsalve Alberto 
Published: January 2021

Se hace una revisión de los mecanismos de daño por hidrógeno, incluyendo el ampollado por hidrógeno, la precipitación interna de hidruros, el agrietamiento por precipitación de hidruros, el ataque por hidrógeno y la fragilización por hidrógeno. Se analizan los tipos de fractura en función de los puntos de residencia del hidrógeno y la interacción del hidrógeno con los aceros, estudiándose las etapas de disolución, difusión y transporte de hidrógeno. Se describe el proceso de “Brush Plating” que se aplica a una superficie con el fin de reparar los daños en los recubrimientos anticorrosivos. Finalmente, se describe el procedimiento para evaluar el daño por hidrógeno en aceros, a través del método de la carga incremental detallado en la norma ASTM F1624-12, analizándose el caso de un acero SAE 4340 sometido a brush-plating en comparación con el mismo acero sometido a carga de hidrógeno. El resultado muestra la validez de la norma aludida en la determinación del daño por hidrógeno en aceros.
Palabras Clave: Daño por hidrógeno; Brush-plating; Método de carga incremental.
Evaluación electroquímica de nuevos inhibidores de corrosión para molienda de minerales con agua de mar
Authors: Rojas Francisca , Fernández Braulio , Magne Luis , Cifuentes Gerardo , Garrido Belén 
Published: January 2021

En las plantas de procesamiento de minerales los medios de molienda, como bolas y barras, son fabricadas de acero; en molienda húmeda, su consumo normalmente es elevado debido a las componentes corrosivas del medio en que se efectúa, lo que provoca que el acero sea clasificado como un insumo crítico dentro del proceso. Es importante in- vestigar cómo evitar o minimizar el impacto económico por consumo de acero en los medios de molienda, para ello se evaluaron electroquímicamente 3 inhibidores de corrosión orgánicos por voltametría lineal y utilizando la aproximación de Tafel, para medir corrientes y potenciales de corrosión. Fueron utilizadas soluciones de agua de mar con diferentes concentraciones de los inhibidores, para pH natural del agua de mar y pH de 9,5. El inhibidor que presenta los mejores resultados bajo las diferentes condiciones de pH y concentración es el inhibidor 3, con pérdidas de espesor promedio de 0,36 mm/año a pH natural y 0,7 mm/año a pH 9,5.
Palabras Clave: Corrosión; inhibidores; bolas; molienda; agua de mar.
MODEL PENGEMBANGAN BUDAYA RELEGIUS DI MADARASAH IBTIDAIYAH DALAM PENGUATAN KARAKTER SISWA
Authors: Sultoniyah Luluk , Royani Ahmad 
Published: January 2021

Moral decadence phenomenon among teenagers includes college student. Lately, it has disturbed many parties. The phenomenon could seen from juvenile deliquency, drug, and free relationship. Higher educational institution that shoud be moral development center and students moral, even in some cases being a moral decadence transit. Therefore, educational institution is not only expected as a place to get knowledge, but also could give enough stock in educating strong student morals to face globalization era. The development of religious culture in MI Al-Barokah An-Nur Ajung Jember is carried out by instilling systematic behavior or manners in practicing their religions, so that they have good personality, character, noble morality, and responsibility, both their relationship with Allah, with human beings and with the environment. therefore, the values developed at MI Al-Barokah An-Nur were emphasizing morality, achievement, discipline and environmental culture.
Fenomena dekadensi moral di kalangan remaja termasuk mahasiswa. Belakangan ini hal itu meresahkan banyak pihak. Fenomena tersebut terlihat dari kenakalan remaja, narkoba, dan hubungan bebas. Perguruan tinggi yang seharusnya menjadi pusat pengembangan moral dan moral siswa, bahkan dalam beberapa kasus menjadi transit dekadensi moral. Oleh karena itu, lembaga pendidikan tidak hanya diharapkan sebagai tempat menimba ilmu, tetapi juga dapat memberikan bekal yang cukup dalam mendidik akhlak siswa yang kuat untuk menghadapi era globalisasi. Pengembangan budaya keagamaan di MI Al-Barokah An-Nur Ajung Jember dilakukan dengan menanamkan perilaku atau tata krama yang sistematis dalam mengamalkan agamanya, sehingga memiliki kepribadian, akhlak, akhlak yang mulia, dan tanggung jawab yang baik, baik hubungannya dengan Allah, maupun hubungan mereka dengan Allah. dengan manusia dan dengan lingkungan. Oleh karena itu nilai-nilai yang dikembangkan di MI Al-Barokah An-Nur adalah mengutamakan moralitas, prestasi, disiplin dan budaya lingkungan.
FEMINISME DAN KETAHANAN PEREMPUAN DALAM DUNIA KERJA DI INDONESIA DAN ISLANDIA
Authors: Hasanah Cici Afifatul , Ferliana Ayu , Adi Depict Pristine 
Published: January 2021

The purpose of this study is describe feminism and the resilience of women in the world of work in Indonesia and Iceland. Feminism as a system of ideas, as a framework and study of social life and human experience that evolved from a women-centered perspective. In Indonesia and Iceland, this is a long history as a reflection of the responsibility regarding the reality of gender inequality. In this study researchers used a research method with the type of literature study. Data collection techniques that utilize secondary data obtained through the library and then described and analyzed to extract from the literature such as books, journals, report, documents and other materials that support this research. Based on the results and discussion that has been presented, it can be concluded that feminism is increasingly developing and being recognized by the world. Feminism and the resilience of women in these two countries have shown that women have great opportunities in the development of the world of work, politics and other fields.
Tujuan dari penelitian ini adalah mendeskripsikan feminisme dan ketahanan perempuan dalam dunia kerja di Indonesia dan Islandia. Feminisme sebagai sistem gagasan, sebagai kerangka kerja dan studi kehidupan sosial dan pengalaman manusia yang berevolusi dari perpsektif yang berpusat pada perempuan. Di Indonesia dan Islandia, hal ini adalah sejarah panjang sebagai cerminan dari tanggung jawab tentang realitas ketidaksetaraan gender. Dalam penelitian ini peneliti menggunakan metode penelitian dengan jenis kajian kepustakaan. Teknik pengumpulan data menggunakan teknik penelitian kepustakaan yang memanfaatkan data sekunder yang diperoleh melalui perpustakaan kemudian di deskripsikan dan dianalisis untuk disarikan dari literatur seperti buku, jurnal, laporan, dokumen dan bahan lain yang mendukung penelitian ini. Berdasarkan hasil dan pembahasan yang telah dipaparkan dapat disimpulkan bahwa feminisme semakin lama semakin berkembang dan diakui oleh dunia. Feminisme dan ketahanan perempuan di dua negara ini sudah menunjukkan bahwa kaum perempuan memiliki peluang besar dalam perkembangan dunia kerja, politik dan bidang lainnya.
MANAJEMEN PENDIDIKAN MULTIKULTURAL PADA ANAK USIA DINI DI SEKOLAH DASAR KATOLIK SUKORENO UMBULSARI JEMBER
Authors: S u l a i m a n S u l a i m a n 
Published: January 2021

This research is motivated by various forms of violence in schools that arise due to the diversity of students in various ways. Thus, multicultural values education is needed in shaping religious character that involves the management process in schools. This research method uses qualitative research methods with the type of field research. Data collection uses observations, interviews and documentaries. the results of this research that management of multicultural education in Catholic Primary Schools (SDK) carried out by maximizing management functions by planning, implementing and supervising the process and results of multicural education itself.

Penelitian ini dilatar belakangi dari munculnya berbagai bentuk kekerasan yang cukup beragam di sekolah yang timbul karena adanya keberagaman yang terjadi antar siswa dalam berbagai hal, sehingga sangat diperlukan adanya pendidikan nilai-nilai multikultural dalam pembentukan karakter religius yang melibatkan serangkaian proses manajemen di sekolah. Metode penelitian ini menggunakan metode penelitian kualitatif dengan jenis penelitian lapangan (field reaserch). pengumpulan datanya menggunakan pengamatan (observasi), wawancara dan dokumenter. Kesimpulan dari penelitian ini adalah manajeman pendidikan multikultural di Sekolah Dasar Katolik (SDK) dilakukan dengan memaksimalkan fungsi-fungsi manajeman yaitu dengan merencanakan, melaksanakan dan mengawasi proses maupun hasil dari pendidikan multikural itu sendiri.
Implementasi Servqual dalam Meningkatkan Mutu Layanan pada Manajemen Pemasaran Pendidikan
Authors: Hidayat Rofiq 
Published: January 2021

Banyaknya lembaga pendidikan yang tidak memberikan pelayanan dengan baik mempengaruhi dalam kepuasan pelanggan pendidikan. akibatnya penerimaan peserta didik baru semakin menurun hingga berujung pada sekolah yang digabung atau ditutup karena jumlah peserta didik tidak sesuai pagu. Untuk itulah perlu adanya peningkatan mutu layanan dalam sebuah manajemen pemasaan pendidikan di lembaga pendidikan dalam rangka menyongsong revolusi industri 4.0. Fokus kajian kali ini adalah bagaimana standar pelayanan pada manajemen mutu terpadu, bagaimana kesenjanganan antara produsen dan pelanggan pendidikan bisa terjadi, dan bagaimana Servqual RATER (Reliability, Assurance, Tangible, Empathy, dan Responsiveness) bisa menjadi solusi sekaligus imlplementasinya di era revolusi industri 4.0. Melalui metode analisis deskriptif, hasil implementasi Servqual tersebut ada pada bagaimana mengimplementasikan RATER dengan konsep manajemen pemasaran era revolusi industri 4.0 yang memiliki tiga ciri, yaitu dari eksklusif ke inklusif, dari vertikal ke horisontal, dan dari individual ke sosial.
Kata Kunci: manajemen pemasaran pendidikan, mutu layanan, Servqual
Many educational institutions do not provide services well for the satisfaction of education customers. As a result, accepting new students decreases to the point where schools are demerged or closed because the number of students does not meet the requirements. To help, it is necessary to improve the quality of services in the management of education at the Educational Institutions in the context of welcoming the industrial revolution 4.0 era. The focus of this study is how the service standards in integrated management, how to manage the handling between suppliers and customers Education can occur, and how Servqual RATER (Reliability, Assurance, Tangible, Empathy, and Responsiveness) can be a solution as well as its implementation in the Industrial Revolution 4.0 era. Through the descriptive analysis method, the results of this Servqual implementation exist when implementing RATER with the Marketing Management concept of the Industrial Revolution era 4.0 which has three features; from exclusive to inclusive, from vertical to horizontal, and from individual to social.