bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early evaluation of treatment response to transarterial chemoembolization in patients with advanced hepatocellular carcinoma: The role of dynamic three-dimensional contrast-enhanced ultrasound
Authors: Cao Jiaying , Dong Yi , Fan Peili , Mao Feng , Chen Kailing , Chen Rongxin , Huang Beijian , Cheng Yaqing , Wang Wen-Ping 
Published: March 2021

BACKGROUND: Dynamic three-dimensional contrast-enhanced ultrasound (3D-CEUS) with quantitative analysis is available in recent years. It can reduce the quantitative sampling error caused by the inconsistency of different sections in order to evaluate local treatment response of hepatocellular carcinoma (HCC) accurately. OBJECTIVE: To investigate the value of dynamic 3D-CEUS in evaluating the early response to transarterial chemoembolization (TACE) treatment in patients with advanced HCC lesions. METHODS: In this prospective study, both two-dimensional (2D) CEUS and dynamic 3D-CEUS were performed on 40 HCC patients who scheduled for TACE at baseline (T0) and 1–3 days (T1) after treatment. Tumor microvascular perfusion changes were assessed by CEUS time-intensity curve (TIC) and quantitative parameters. According to contrast-enhanced computed tomography (CT) and magnetic resonance (MR) imaging 1 month after treatment results, patients were divided into responders and non-responders groups. The changes of perfusion parameters of both 2D-CEUS and 3D-CEUS were compared between responders and non-responders groups before and after TACE treatment. RESULTS: Before and after TACE treatment, no significant difference in maximum diameter of HCC lesions between the two groups could be found. There were more significant differences and ratios of perfusion parameters in 3D-CEUS quantitative analysis than in 2D-CEUS. The mutual significant differences and ratios of 2D-CEUS and 3D-CEUS included peak intensity (PI) difference, PI ratio, ratio of area under the curve (A), ratio of area under the wash-out part (AWO) and slope (S) difference. The former 4 corresponding parameters were better on 3D-CEUS than on 2D-CEUS. CONCLUSION: Dynamic 3D-CEUS can be used as a potential imaging method to evaluate early treatment response to TACE in advanced HCC patients.
Development and Validation of a Prognostic Nomogram for Gastric Signet Ring Cell Carcinoma: A Multicenter Population-Based Study
Authors: Zhang Shuairan , Liu Yang , Jiao Zihan , Li Zenan , Wang Jin , Li Ce , Qu Xiujuan , Xu Ling 
Published: March 2021

BackgroundGastric signet ring cell carcinoma (GSRCC) is a rare disease associated with poor prognosis. A prognostic nomogram was developed and validated in this study to assess GSRCC patients’ overall survival (OS).MethodsPatients diagnosed with GSRCC from the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016) and the First Hospital of China Medical University (CMU1h) were enrolled in this retrospective cohort study. Univariate and multivariate COX analysis was used to determine independent prognostic factors to construct the prognostic nomogram. Predictions were evaluated by the C-index and calibration curve. In addition, the receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and Kaplan-Meier analysis were employed to assess the clinical utility of the survival prediction model.ResultsPatients were classified into two cohorts. We randomly divided patients in the SEER database and CMU1h cohort into a training group (n=3068, 80%) and a validation group (n=764, 20%). Age, race, T stage, N stage, M stage, therapy, and tumor size were significantly associated with the prognosis of GSRCC patients. On this basis, a nomogram was constructed, with a C-index in the training and the validation cohorts at 0.772 (95% CI: 0.762–0.782) and 0.774 (95% CI: 0.752–0.796), respectively. The accuracy of the generated nomogram was verified through calibration plots. Similarly, compared with the traditional AJCC staging system, the results of the area under curve (AUC) calculated by ROC, DCA, and Kaplan-Meier curves, demonstrated a good predictive value of the constructed nomogram, compared to the traditional AJCC staging system.ConclusionIn the present study, seven independent prognostic factors of GSRCC were screened out. The established nomogram models based on seven variables provided a visualization of each prognostic factor’s risk and assisted clinicians in predicting the 1-, 3-, and 5-year OS of GSRCC.
Predicting Survival Duration With MRI Radiomics of Brain Metastases From Non-small Cell Lung Cancer
Authors: Chen Bihong T. , Jin Taihao , Ye Ningrong , Mambetsariev Isa , Wang Tao , Wong Chi Wah , Chen Zikuan , Rockne Russell C. , Colen Rivka R. , Holodny Andrei I. , Sampath Sagus , Salgia Ravi 
Published: March 2021

Background: Brain metastases are associated with poor survival. Molecular genetic testing informs on targeted therapy and survival. The purpose of this study was to perform a MR imaging-based radiomic analysis of brain metastases from non-small cell lung cancer (NSCLC) to identify radiomic features that were important for predicting survival duration.Methods: We retrospectively identified our study cohort via an institutional database search for patients with brain metastases from EGFR, ALK, and/or KRAS mutation-positive NSCLC. We segmented the brain metastatic tumors on the brain MR images, extracted radiomic features, constructed radiomic scores from significant radiomic features based on multivariate Cox regression analysis (p &lt; 0.05), and built predictive models for survival duration.Result: Of the 110 patients in the cohort (mean age 57.51 ± 12.32 years; range: 22–85 years, M:F = 37:73), 75, 26, and 15 had NSCLC with EGFR, ALK, and KRAS mutations, respectively. Predictive modeling of survival duration using both clinical and radiomic features yielded areas under the receiver operative characteristic curve of 0.977, 0.905, and 0.947 for the EGFR, ALK, and KRAS mutation-positive groups, respectively. Radiomic scores enabled the separation of each mutation-positive group into two subgroups with significantly different survival durations, i.e., shorter vs. longer duration when comparing to the median survival duration of the group.Conclusion: Our data supports the use of radiomic scores, based on MR imaging of brain metastases from NSCLC, as non-invasive biomarkers for survival duration. Future research with a larger sample size and external cohorts is needed to validate our results.
Characteristic of Tumor Regrowth After Gamma Knife Radiosurgery and Outcomes of Repeat Gamma Knife Radiosurgery in Nonfunctioning Pituitary Adenomas
Authors: Li Yanli , Wu Lisha , Quan Tingting , Fu Junyi , Cao Linhui , Li Xi , Liang Shunyao , Huang Minyi , Deng Yinhui , Yu Jinxiu 
Published: March 2021

ObjectiveThis study aimed to report the characteristic of tumor regrowth after gamma knife radiosurgery (GKRS) and outcomes of repeat GKRS in nonfunctioning pituitary adenomas (NFPAs).Design and MethodsThis retrospective study consisted of 369 NFPA patients treated with GKRS. The median age was 45.2 (range, 7.2–84.0) years. The median tumor volume was 3.5 (range, 0.1–44.3) cm3.ResultsTwenty-four patients (6.5%) were confirmed as regrowth after GKRS. The regrowth-free survivals were 100%, 98%, 97%, 86% and 77% at 1, 3, 5, 10 and 15 year, respectively. In multivariate analysis, parasellar invasion and margin dose (&lt;12 Gy) were associated with tumor regrowth (hazard ratio [HR] = 3.125, 95% confidence interval [CI] = 1.318–7.410, p = 0.010 and HR = 3.359, 95% CI = 1.347–8.379, p = 0.009, respectively). The median time of regrowth was 86.1 (range, 23.2–236.0) months. Previous surgery was associated with tumor regrowth out of field (p = 0.033). Twelve patients underwent repeat GKRS, including regrowth in (n = 8) and out of field (n = 4). Tumor shrunk in seven patients (58.3%), remained stable in one (8.3%) and regrowth in four (33.3%) with a median repeat GKRS margin dose of 12 (range, 10.0–14.0) Gy. The actuarial tumor control rates were 100%, 90%, 90%, 68%, and 68% at 1, 3, 5, 10, and 15 years after repeat GKRS, respectively.ConclusionsParasellar invasion and tumor margin dose (&lt;12 Gy) were independent risk factors for tumor regrowth after GKRS. Repeat GKRS might be effective on tumor control for selected patients. For regrowth in field due to relatively insufficient radiation dose, repeat GKRS might offer satisfactory tumor control. For regrowth out of field, preventing regrowth out of field was the key management. Sufficient target coverage and close follow-up might be helpful.
The Role of Chemotherapy in Patients With HER2-Negative Isolated Locoregional Recurrence of Breast Cancer: A Multicenter Retrospective Cohort Study
Authors: Lee Kyoungmin , Sim Sung Hoon , Kang Eun Joo , Seo Jae Hong , Chae Heejung , Lee Keun Seok , Kim Ji-Yeon , Ahn Jin Seok , Im Young-Hyuck , Park Seri , Park Yeon Hee , Park In Hae 
Published: March 2021

Background: The role of chemotherapy for isolated locoregional recurrence (iLRR) of breast cancer has not been firmly established after local therapies.Methods: We performed a multicenter, retrospective analysis to evaluate the clinical implications of chemotherapy in breast cancer patients with HER2-negative iLRR.Results: Of a total of 277 patients, 146 (52.7%) received chemotherapy for iLRR. Median follow-up duration was 56.1 months. Eighty-six (31.0%) patients had luminal B-like and 100 (36.1%) had TNBC iLRR. There was a trend of longer disease free survival (DFS) in the chemotherapy group (4-year DFS: 70.4 vs. 59.5%, HR = 0.68, 95% CI 0.45–1.02, log-rank p = 0.059). When adjusted with clinically relevant factors, DFS was significantly prolonged with chemotherapy (adjusted HR = 0.61, 95% CI 0.40–0.94, p = 0.023). Subgroup analyses for DFS showed patients with disease free interval (DFI) &lt;5 years or prior chemotherapy had a benefit from chemotherapy (adjusted HR = 0.57, p = 0.018; adjusted HR = 0.51, p = 0.005, respectively). Regarding the molecular subtypes, a longer DFS with chemotherapy was observed both in luminal B-like (4-year DFS: 77.8 vs. 55.0%, HR = 0.51, 95% CI 0.27–0.99, log-rank p = 0.048) and in TNBC patients (4-year DFS: 61.9 vs. 42.8%, HR = 0.49, 95% CI 0.24–1.02, log-rank p = 0.056), but not in luminal A-like.Conclusions: The chemotherapy for iLRR of breast cancer should be individualized for each patient, considering DFI, prior chemotherapy, and molecular subtypes.
A Question of Presence and Agency
Authors: Gaber Tammy 
Published: March 2021

New scholarship, covered by the books in this review essay, include studies of mosques in the UK, Canada, Spain and Australia and demonstrate that the proclamation of presence of the architecture of the mosque works on a number of levels. The exterior façade, of course, functions to symbolize some sort of landmark and identity in a variety of possible architectural languages. However, the interior, is where the differences truly lie between the mosque in constructed in the Muslim world and those constructed outside of the Muslim world. For minority communities, the mosque program necessarily includes facilities for education, recreation, festive gathering and dining in addition to other specific programs such as funeral preparation, food bank collection and so forth.
The contemporary mosque in the non-Muslim world, regardless of how west, north or south it is located, is loaded with much more programmatic demand in addition to the perceived politics of creating presence and identity in a perceived foreign landscape.
To download full review, click on PDF.
Sistem Pendukung Keputusan Untuk Menentukan Penerima Beasiswa Menggunakan Metode AHP-TOPSIS
Authors: Amelia Diyona , Auliasari Karina , Primaswara Prasetya Renaldi 
Published: March 2021

ITN Malang merupakan salah satu perguruan tinggi yang memiliki program beasiswa bagi mahasiswanya. Salah satunya yaitu Beasiswa Peningkatan Prestasi Akademik atau biasa disingkat dengan PPA. Setiap tahun ITN diberi kuota jumlah mahasiswa yang akan menerima beasiswa PPA dari Direktorak Pembelajaran dan Kemahasiswaan, Kemristekdikti, Kopertis Wilayah VII. Pelaksanaan program beasiswa ini ditangani oleh bidang kemahasiswaan sesuai dengan persyaratan dan ketentuan yang telah ditetapkan oleh kemenristekdikti. Program ini biasanya diawali dengan adanya pengumuman disetiap prodi yang disertai dengan ketentuan dan persyaratan yang harus di patuhi dan dilengkapi. Proses penyeleksian sendiri biasaya dilakukan oleh tim yang memang telah dibentuk oleh pihak kemahasiswaan dan proses ini biasanya membutuhkan waktu yang cukup lama, karena ada banyak aspek yang dipertimbangkan, prosesnya juga masih dilakukan secara manual. dan mereka juga harus tau mana yang lebih diprioritaskan dari aspek-aspek tersebut. Dibutuhkan sesuah sistem untuk membantu proses seleksi penerima beasiswa Peningkatan Prestasi Akademik (PPA), pada penelitian ini sistem seleksi menerapkan metode AHP untuk penentuan bobot kriteria dan metode TOPSIS untuk proses perangkingan. Dari hasil pengujian sistem, proses seleksi menggunakan metode AHP-TOPSIS sudah sesuai dengan perhitungan manual, setelah dilakukan perbandingan dengan metode TOPSIS diperoleh nilai rata-rata selisih sebesar 0.032138, dan urutan hasil perangkingan antara metode AHP-TOPSIS dan metode TOPSIS sama, dan didapatkan nilai akurasi dari perbandihan hasil seleksi sistem dengan hasil seleksi itn malang sebesar 82% .
Design and Selection of The Face Shield Materials as a Self-Protective Tool in Preventing COVID-19 using The Analytical Hierarchy Process Method
Authors: L Pattiapon Marcy 
Published: March 2021

The world has been shocked by the emergence of COVID-19 since December 2019 which is an acute respiratory disease caused by a corona virus called severe acute respiratory syndrome coronavirus 2 or abbreviated as SARSCoV-2 (Gorbalenya et al., 2020). As of June 17, 2020, the World Health Organization (WHO) noted that there were 8,061,550 people infected with COVID-19 and 440,290 people died (WHO,
2020a). Even though the Case Fatality Rate (CFR) of COVID-19 is only around 5.46%, this disease is very dangerous because of its spread so fast it has infected 216 countries (Worldometer, 2020). To prevent uncontrolled spread, WHO declared COVID-19 a pandemic on March 11, 2020 (WHO, 2020b) to increase awareness of this disease. The status of this pandemic is a concern for the world to make various efforts to prevent the spread of COVID-19. One way to protect yourself from spreading COVID-19 is to use Personal Protective Equipment. Face shield is a personal protective device that functions to protect the face from exposure to dangerous substances in the case of the spread of the Covid-19 virus. A good face shield is a face shield that has a high level of durability, has high material quality, has a sufficient level of elasticity, and the costs incurred are not too expensive.In choosing the best alternative in making a decision, the right method is needed so that the best alternative is obtained from various predetermined criteria.Then the Analytical Hierarchy Process (AHP) method is used to select the best alternative material to be used in making the Face Shield.
Based on the results of the research conducted, it can be seen that each alternative has the advantage of the criteria felt by the respondent.However, of the four criteria for

selecting the face shield material, the most superior or chosen as the choice is mica.Judging from the percentage of mica against the Durability criteria is 31.7%, the percentage of mica against the quality criteria is 43.1%.
Exploring the Relationship Between Locus of Control and Financial Behavior of Accounting Student from The Social Construction Theory Approach
Authors: Radianto Wirawan ED , Kristama Baswara Yua , Salim Ika Raharja 
Published: March 2021

This research examines the effect of locus control on financial literacy, including financial attitude, financial behavior, and financial self-efficacy. This study used a survey method by sending a questionnaire to the respondent through an enumerator. This study uses a sample, namely students of the accounting study program in Surabaya, Indonesia. A total of 159 questionnaires were processed from distributing 250 questionnaires randomly. This study uses the Partial Least Square data analysis. The result shows that locus of control affects financial attitude, financial behavior, and financial self-efficacy. Financial behavior increases when the respondents show excellent financial knowledge behavior and believe that they can manage for their finances. This investigation confirms that locus of control affects financial behavior. Meaning the role of locus of control is very important to increase financial behavior. This study also found that locus of control can contribute to the theory of social construction. Moreover, social construction theory can predict how individuals act to improve their financial behavior.

Received: 15 October 2020 / Accepted: 19 December 2020/ Published: 5 March 2021
Graphic Design for Children with Learning Disabilities Based on the Isaan Mural Painting
Authors: Plengdisakul Pakinee , Phothisane Souneth , Soodsang Nirat 
Published: March 2021

The study of 'Graphic design for children with learning disabilities' is a study that delves into learning-disabled children in the Isaan region. The author used the survey to formulate a graphic and media design model to enhance LD children's learning. This paper is a qualitative study of the data retrieved from the literature review and field data. Target groups include experts, practitioners, and stakeholders. Research instruments are structured and non-structured interviews, observation forms, and tests. The collected data were then analyzed using the 'information processing theory,' 'structural-functional theory,' product design principle, and graphic design element principle. The paper presents the result using descriptive analysis. Based on the study, it was found that the cause for learning disabilities in children living in Isaan mostly concerns with environmental learning disabilities. The best period for children with learning disabilities to effectively receive help is during their early primary or elementary education. The types of learning disabilities that can be found in children in the Isaan region are mostly reading and writing disabilities. Further, it was also revealed that Nakhonratchasima Primary Education Service Area 2 has the highest rate of learning-disabled children in Isaan. Most of the children with learning disabilities did not receive proper care from their caretakers. To identifying children with learning disabilities, the author collaborated with the children's caretakers, schools, Special Education Bureau, and hospitals. Common classroom behaviors among these children are their inability to read and write; this includes difficulties in social interactions and activity participation. As for the learning materials, it is clear that the materials used did not correspond with their special needs due to their disabilities. It is clear that these children need materials made for individual use that does not require participation in front of the class or learning through multimedia. The discovery can be used as a guideline in formulating graphic design. The graphic design should make insignificant information less distinct while reinforcing the main contents with bold lines, complementary colors, page distance, pictures used in representing alphabets, and the adoption of fun and creative characters. As for the material design guideline, the media should focus on one story for individual use. Students should also learn through playing, repeated reading, writing practice, using materials repeatedly without being bored, and can memorize the lessons when participating in hands-on activities.

Received: 23 December 2020 / Accepted: 11 February 2021 / Published: 5 March 2021
Remembering the Albanian Communism: The Creation of the Collective Memory Through the Lens of the Literature of Memory of the Albanian Catholic Clergy
Authors: Doçe Eljon , Halili Erenestina Gjergji 
Published: March 2021

This paper aims to analyze the contribution that the literature of memory is giving in the process of constructing the collective memory about the Albanian communism. The main work, which is the central part of our research, is about Father Zef Pllumi’s book “Live only to tell” which is considered as a monument of the collective memory regarding the Albanian experience during communism. Also, this paper aims to analyze the contribution of other Albanian Catholic clergy had in facing the communist regime in Albania and the legacy they left in creating the Albanian collective memory. The method of research used is a textual analysis of the narration and the relation between fiction and history, between the general historical myth and the personal truth, which is a very interesting type of literature that is written like history but, at the same time, it feels like fiction. After the fall of communism in Albania, the Albanians, especially those who were subjected to this extreme violence and oppression, felt the need to share their experience in various ways. One way was through the literature of memory, which is an important element in the process of the creation of collective memory for a very disturbing past for every post-communist country.

Received: 3 November 2020 / Accepted: 19 December 2020 / Published: 5 March 2021
Real Exchange Rate and Manufacturing Performance in Nigeria
Authors: Asaleye Abiola John , Maimako Rotdelmwa Filibus , Inegbedion Henry , Lawal Adedoyin Isola , Ogundipe Adeyemi A. 
Published: March 2021

The efficacy of currency devaluation to improve output in Nigeria is under debate, and coupled with an unsatisfactory result in the behaviour of the manufacturing sector performance regenerated interest of this study to investigate the impact of exchange rate on output and employment in the sector. The work uses Structural Vector Autoregression, ECM and Canonical Co-integrating Regression to examine the shock effect, short and long-run elasticities of exchange rate on the manufacturing performance. While employment and output are used as a proxy for manufacturing sector performance. The findings show that changes in the exchange rate are fairly elastic with output and employment both in short and long-run. However, changes in the exchange rate are insignificant with employment in the short run. The variance decomposition form the SVAR shows that forecast error shock of the exchange rate is more prolong on employment than output. Consequently, the result of the estimation of the Impulse Response Function from the Monte Carlos shows that one standard deviation of the exchange shock adversely affect employment. The outcome of the result indicates that the Nigerian exchange rate has not improved output and employment in the manufacturing sector. Several factors may be accounted for this, although, it may be due to cost-push inflationary pressure and unfavourable competitiveness. The study suggests the need to encourage long-term supply-side policies among others to improve the situation.

Received: 7 June 2020 / Accepted: 9 January 2021 / Published: 5 March 2021
Rapport au système représentatif et soutien à la démocratie directe et délibérative. Analyse comparée des attitudes des élus nationaux en Europe
Authors: Close Caroline 
Published: March 2021

Cet article examine les facteurs du soutien à deux types de dispositifs alternatifs à la démocratie représentative : les référendums et les assemblées délibératives, via une enquête menée auprès d’un peu plus de 900 parlementaires nationaux dans 14 pays européens (2009-2012). Les données révèlent au niveau agrégé un soutien moins marqué aux référendums qu’aux événements délibératifs. L’analyse statistique met en avant des facteurs explicatifs distincts du soutien à ces deux types de dispositifs, liés à l’affiliation partisane des parlementaires, mais aussi à leur évaluation du fonctionnement du système représentatif et de ses protagonistes.