bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Proportion of Excised Cone Volume for Cervical Lesions is the Best Predictor of Pregnancy Outcomes after Cervical Conization
Authors: Wang Yahui , Lin Wei , Luo Youjun , Niu Zhaoyuan , Du Yanhui , Lv Yingpin , Cui Zhumei , Zhang Yan , Yuan Fang 
Published: February 2021

Abstract
Background: As much more women in the reproductive period are treated with a cervical conization, the risk of subsequent adverse pregnancy outcomes is also increasing. We carried the present study to evaluate whether absolute cone length/volume and the proportions of the cone length/volume correlate to spontaneous abortion (SAB) and spontaneous preterm birth (SPTB) and their predictive values.Methods: The present retrospective observational study included 312 women undergoing cervical conization for cervical lesions at the Affiliated Hospital of Qingdao University during 2012–2019. The information about the pretreatment cervical dimensions and cone size and pregnancy outcomes were collected to assess the correlation between cone parameters and pregnancy outcomes.Results: In the multivariate logistic regression models, the cervical length excised, the cervical volume excised, the proportion of the length excised, and the proportion of the cervical volume excised significantly correlated with SAB and SPTB, respectively (P<0.05). A most significant inverse correlation of the proportion of the cervical volume excised with pregnancy duration emerged (P<0.001, r=-0.220). The area under the curve (AUC) of the proportion of the cervical volume excised was greatest (0.700,95% CI 0.634-0.765). And the risk of SAB and SPTB increased with the proportion of the cervical volume excised increasing (OR 19.704, 95% CI 4.646-83.568). The cutoff point of the proportion of the cervical volume excised was 19.5% (sensitivity 0.635; specificity 0.655). Conclusion: The cone length/volume and the proportions of cervical length/volume excised were associated with increased risks of SAB and SPTB. The proportion of the cervical volume excised is the best predictor for SAB and SPTB after cervical conization. When the proportion of the cervical volume excised is more than 19.5%, women should be informed about their future risk of SAB and SPTB after cervical conization for cervical lesions.
Genomic analyses of 10,376 individuals provides comprehensive map of genetic variations, structure and reference haplotypes for Chinese population
Authors: Zheng Houfeng , Cong Peikuan , Bai Weiyang , Li Jinchen , Li Nan , Gai Sirui , Khederzadeh Saber , Liu Yuheng , Qiu Mochang , Zhu Xiaowei , Zhao Pianpian , Xia Jiangwei , Yu Shihui , Zhao Weiwei , Liu Junquan , Guan Penglin , Qian Yu , Tao Jianguo , Yang Mengyuan , Tian Geng , Xie Shuyang , Liu Keqi , Tang Beisha 
Published: February 2021

Abstract
Here, we initiated the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-genome sequencing individuals and 5,481 high-density genotyping individuals. We identified 80.99 million SNPs and INDELs, of which 38.6% are novel. The genetic evidence of Chinese population structure supported the corresponding geographical boundaries of the Qinling-Huaihe Line and Nanling Mountains. The genetic architecture within North Han was more homogeneous than South Han, and the history of effective population size of Lingnan began to deviate from the other three regions from 6 thousand years ago. In addition, we identified a novel locus (SNX29) under selection pressure and confirmed several loci associated with alcohol metabolism and histocompatibility systems. We observed significant selection of genes on epidermal cell differentiation and skin development only in southern Chinese. Finally, the WBBC haplotype panel, which is a population-specific reference panel, yielded substantial improvement of imputation performance in Chinese population for low-frequency and rare variants compared to 1KG Project, and merging EAS individuals to increase the haplotype size of WBBC could improve the performance across all MAF bins. We provided an online imputation server (https://wbbc.westlake.edu.cn/) which could result in higher imputation accuracy compared to the existing panels, especially for lower frequency variants.
Efficacy of Percutaneous Transforaminal Endoscopic Discectomy Unilateral and Bilateral Approach for Bilateral Decompression in Treatment of Degenerative Lumbar Spinal Stenosis and Their Effects on Quality of Life
Authors: Cai Xianbin , Lin Haibin , Chen Xuanhuang , Cai Hanhua , Zheng Feng , Wu Changfu 
Published: February 2021

Abstract
The authors have requested that this preprint be removed from Research Square.
Feasibility and Efficacy of a Decision Aid for Emergency Department Patients with Suspected Ureterolithiasis: Protocol for an Adaptive Randomized Controlled Trial
Authors: Schoenfeld Elizabeth M , Poronsky Kye E , Westafer Lauren M , Visintainer Paul , DiFronzo Brianna M , Scales Charles D , Hess Erik P , Lindenauer Peter K 
Published: February 2021

Abstract
Background: Approximately 2 million patients present to Emergency Departments in the US annually with signs and symptoms of ureterolithiasis (or renal colic, the pain from an obstructing kidney stone). Both ultrasound and CT scan can be used for diagnosis, but the vast majority of patients receive a CT scan. Diagnostic pathways utilizing ultrasound have been shown to decrease radiation exposure to patients but are potentially less accurate. Because of these and other trade-offs, this decision has been proposed as appropriate for Shared Decision-Making (SDM), where clinicians and patients discuss clinical options and their consequences and arrive at a decision together. We developed a decision aid to facilitate SDM in this scenario. The objective of this study is to determine the effects of this decision aid, as compared to usual care, on patient knowledge, radiation exposure, engagement, safety, and healthcare utilization. Methods: This is the protocol for an adaptive randomized controlled trial to determine the effects of the intervention – a decision aid (“Kidney Stone Choice”) – on patient-centered outcomes, compared with usual care. Patients age 18-55 presenting to the Emergency Department with signs and symptoms consistent with acute uncomplicated ureterolithiasis will be consecutively enrolled and randomized. Participants will be blinded to group allocation. We will collect outcomes related to patient knowledge, radiation exposure, trust in physician, safety, and downstream healthcare utilization. Discussion: We hypothesize that this study will demonstrate that “Kidney Stone Choice,” the decision aid created for this scenario, improves patient knowledge and decreases exposure to ionizing radiation. The adaptive design of this study will allow us to identify issues with fidelity and feasibility and subsequently evaluate the intervention for efficacy. Trial registration: ClinicalTrials.gov - NCT04234035https://clinicaltrials.gov/ct2/show/NCT04234035Registered January 21, 2020 – Retrospectively Registered
The Impact of Improved Water Supply on Cholera and Diarrhoeal Diseases in Uvira, Democratic Republic of the Congo: A Protocol for a Pragmatic Stepped-Wedge Cluster Randomised Trial and Economic Evaluation
Authors: Gallandat Karin , Jeandron Aurélie , Ross Ian , Saidi Jaime Mufitini , Rumedeka Baron Bashige , Kapepula Vercus Lumami , Cousens Simon , Allen Elizabeth , MacDougall Amy , Cumming Oliver 
Published: February 2021

Abstract
Introduction. Diarrhoeal disease remains a leading cause of mortality and morbidity worldwide. Cholera alone is estimated to cause 95,000 deaths per year, most of which occur in endemic settings with inadequate water access. Whilst a global strategy to eliminate cholera by 2030 calls for investment in improved drinking water services, there is limited rigorous evidence for the impact of improved water supply on endemic cholera transmission in low-income urban settings. Our protocol is designed to deliver a pragmatic health impact evaluation of a large-scale water supply intervention in Uvira (Democratic Republic of the Congo), a cholera transmission hotspot. Methods/Design.A stepped-wedge cluster randomised trial (SW-CRT) was designed to evaluate the impact of a large-scale drinking water supply intervention on cholera incidence among the 280,000 inhabitants of Uvira. The city was divided into 16 clusters, where new community and household taps will be installed following a randomised sequence over a transition period of up to 8 weeks in each cluster. The primary trial outcomes are the monthly incidence of “confirmed” cholera cases (patients testing positive by rapid detection kit) and of “suspected” cholera cases (patients admitted to the cholera treatment centre). Concurrent process and economic evaluations will provide further information on the context, costs and efficiency of the intervention. Discussion.In this protocol, we describe a pragmatic approach to conducting rigorous research to assess the impacts of a complex water supply intervention on severe diarrhoeal disease and cholera in an unstable, low-resource setting representative of cholera-affected areas. In particular, we discuss a series of pre-identified risks and linked mitigation strategies as well as the value of combining different data collection methods and preparation of multiple analysis scenarios to account for possible deviations from the protocol. The study described here has the potential to provide robust evidence to support more effective cholera control in challenging, high-burden settings. Trial registration. This trial is registered on clinicaltrials.gov (NCT02928341, 10th October 2016, https://clinicaltrials.gov/ct2/show/NCT02928341) and has received ethics approval from the London School of Hygiene and Tropical Medicine (8913, 10603) and from the Ethics Committee from the School of Public Health, University of Kinshasa, Democratic Republic of the Congo (ESP/CE/088/2015).
Relativity and View Effects
Authors: Fischli Bernard 
Published: February 2021

Abstract
Relativity has been based on the implicit assumption that electromagnetism would exclusively describe interactions. Relativistic view effects are included as well, and they act with no force and no energy exchanges. The Ehrenfest paradox is solved. View effects specific to each point of view are the solution. The calculation of the deflection of light by the sun explains in detail why the deflection angle must be almost double the value obtained with Newton’s laws. The compatibility of General Relativity with the new interpretation is discussed. View effects cannot impact total energy. An object has no speed limit due to relativity but can be limited due to other causes. Inertial behavior is examined. Inertial masses are redundant, but this does not introduce gravitation to General Relativity.
Effective Inhibition of Mitochondrial Metabolism by Cryptotanshinone in
MDA-MB231 cells: A Proteomic Analysis
Authors: Zhou Jiefeng , Li Qingcao , Wu Haoran , Tsai Shin-Han , Yeh Yu-Ting 
Published: February 2021

Background :
Triple-negative breast cancer (TNBC) is a subtype of invasive cancer in breast with the symptoms of unfavourable prognosis and limited targeted treatment options. Evidence of changes in the metabolic status of TNBC, characterised by increased glycolysis, mitochondrial oxidative phosphorylation, as well as production and utilization of tricarboxylic acid cycle intermediates.

Objective:
Investigate the proteins altered in cryptotanshinone treated MDA-MB-231 cells and explore the key pathways and specific molecular markers involved in cryptotanshinone treatment.

Method:
We use unlabeled quantitative proteomics to gain insight into the anticancer mechanism of cryptotanshinone on MDA-MB231 triple negative breast cancer cells. And flow cytometry was used to detect apoptosis and changes in cell mitochondrial membrane potential.

Results:
We show that inhibiting the expression of electron transport chain complex proteins, also inhibits mitochondrial oxidative phosphorylation. Additionally, down-regulation of the ribosime biogenesis pathway was found to inhibit cell metabolism.

Conclusion:
In summary, results show that cryptotanshinone can trigger rapid and irreversible apoptosis in MDA-MB-231 cells through effectively inhibiting cell metabolism.
Screening clinical signs of TB in HIV-infected convicts in correctional facilities federal penitentiary servicе
Authors: Borovitsky V. S. 
Published: February 2021

Aim. To identify the main clinical signs that make it possible to further detect the development of tuberculosis in patients with HIV infection in a correctional facility of the Federal Penitentiary Service with a high degree of probability.Materials and methods: 569 patients with tuberculosis, 363 with HIV infection, and 206 prisoners without HIV infection. Age: from 18 to 62 years old.Results. In this study, we have identiﬁed highly probable clinical symptoms in HIV-infected prisoners in the presence of tuberculosis and weakness, cough, clinical manifestations of mycosis, hepatomegaly and lymphadenopathy. The sensitivity of detecting tuberculosis in patients with HIV infection for complaints of weakness — 61,2%, speciﬁcity — 57,3%, cough with sputum — 67,8 and 51,0%, clinical manifestation of mycosis — 95,6 and 80,6%, hepatomegaly — 48,8 and 100%, lymphadenopathy — 50,4 and 100,0%, respectively. The combined combination of these clinical manifestations gives a sensitivity of 94,6% with 81,9% speciﬁcity. The percentage of correctly classiﬁed cases according to this model is 88,93%, with the area under the ROC curve (AUC) — 0,963.
THE PERCEPTION ON THE USE SOCIAL MEDIA IN LEARNING ENGLISH
Authors: Handayani Rahmawati Dwi , Syafei Muh Syafei , Perwikasih Utari Aisyah Ririn 
Published: February 2021

Abstract The objective of the research to know the perception of fourth semester students of Universitas Muria Kudus on the use social media in learning English. The researcher used descriptive qualitative research and the data was collected by the used of questionnaire. The participants are 50 students of English Education Department of Universitas Muria Kudus. The result showed social media have good perception for the fourth semester students of English Education Department of Universitas Muria Kudus. Social media have provide rich resource to learn English. It is indicate that social media has positive contribution for learning English they are listening, reading, writing and speaking skill.
EVALUASI PROGRAM KAMPUNG KELUARGA BERENCANA DALAM MENINGKATKAN KETAHANAN DAN KESEJAHTERAAN KELUARGA
Authors: Resnawaty Risna , Humaedi Sahadi , Adiansah Wandi 
Published: February 2021

ABSTRAKArtikel ini merupakan hasil penelitian mengenai program kampung keluarga berencana di Dusun Jenawi, Desa Mertasinga, Kecamatan Gunung Jati, Kabupaten Cirebon. Dusun Jenawi merupakan tempat dimana pertama kali program Kampung KB digulirkan oleh Presiden RI Joko Widodo pada tahun 2016. Tujuan program Kampung KB ini sendiri adalah untuk meningkatkan ketahanan dan kesejahteraan keluarga. Penelitian ini bertujuan untuk mengevaluasi Program Kampung Keluarga Berencana di dusun Jenawi setelah 4 tahun program ini berjalan. Penelitian ini menggunakan pendekatan kualitatif dengan metode penelitian. Hasil penelitian menunjukkan adanya perubahan pada tingkat Kesehatan dan kesejahteraan keluarga, namun perubahannya sangat lambat dan kurang signifikan. Salah satu penyebabnya adalah kurangnya sumber daya manusia sebagai tenaga pelaksana kampung. Berdasarkan hal tersebut diperlukan adanya peningkatan kapasitas kader agar ketahanan dan kesejahteraan keluarga dapat terwujudkan dan terjadi peningakatn kesejahteraan pada masyarakat dusun Jenawi
WORKSHOP PENERAPAN METODE FIFO PADA GUDANG PERSEDIAAN BARANG DI TOKO KEMANGGISAN
Authors: Usman Ridwan , Rusmiland Rimsa , Putra Muhammad Fidiandri 
Published: February 2021

Persediaan merupakan salah satu perkiraan yang terpenting dalam sebuah perusahaan. Bagi perusahaan, persediaan merupakan asset yang cukup besar nilainya. Konsep penyimpanan diperlukan untuk pemenuhan keberlangsungan usaha. Toko Kemanggisan merupakan unit usaha mini market, toko serba ada menyediakan kebutuhan bahan pokok, peralatan kantor serta perabotan rumah tangga, terutama untuk memenuhi kebutuhkan warga sekitar. Lokasi gudang penyimpanan yang bersebelahan dengan Toko Kemanggisan, saat ini sistem penyimpanan barang di Toko Kemanggisan belum menerapkan konsep penyimpanan salah satunya metode FIFO (First In First Out). Kegiatan pengabdian masyarakat di Toko Kemanggisan. Diawali wawancara untuk penentuan kebutuhan mitra, peserta workshop adalah bagian persediaan yaitu staff administrasi dari supplier, staff gudang dan manager operasional, workshop pemahaman, materi penerapan praktik penyimpanan barang dan metode FIFO (First In First Out). Workshop ini menambah ilmu, pengetahuan cara menyimpan barang yang efektif, kemudahan akses pengambilan barang lebih yang cepat dan penyimpanannya lebih teratur.
SOSIALISASI MANAJEMEN KINERJA TENAGA KESEJAHTERAAN KECAMATAN DALAM PENANGGULANGAN MASALAH KESEJAHTERAAN SOSIAL DI KECAMATAN KARAWANG BARAT
Authors: Purnamasari Hanny , Ramdani Rachmat 
Published: February 2021

Permasalahan sosial di tengah masyarakat seperti kemiskinan, keterlantaran, ketunaan sosial dan penyimpnagan perilaku mendorong pemerintahan untuk segera mengambil tindakan untuk penanggan melaui pendekatan secara sistematis terpadu dan menyuluruh dalam rangka mengurangi permasalahan kesejahteraan sosial serta memenuhi kebutuhan dasar warga negara secara layak. Pengabdian kepada masayarakat ini bertujuan untuk menjelaskan dan memberikan pemahaman tentang manajemen kinerja tenaga kesejahteraan dalam penanggulangan masalah kesejahteraan sosial. Metode pengabdian kepada masyarakat ini dilakan dengan cara ceramah dan tatap muka yang akan dilaksanakan di aula Kecamatan Karawang Barat Kabupaten Karawang. Pemaparan materi disampaikan oleh pelaksana pengabdian yang merupakan staf pengajar Program Studi Ilmu Pemerintahan Universitas Singaperbangsa Karawang. Tenaga kesejahteraan diharapkan berpartisipasi aktif terkait dengan topik dengan dibukanya sesi tanya jawab.
INTERVENSI KEMANUSIAAN NATO DI LIBYA : ANALISIS JUS IN BELLO
Authors: Swastika Mayora Bunga 
Published: February 2021

The Arab Spring is a term for the revolutions of countries in the Middle East. The Arab Spring has a purpose to overthrow a dictatorial government. The series of Arab Spring began with protest in Tunisia on December 18, 2010. This protest started with Mohamed Bouazizi, a Tunisian street vendor, who set himself on fire as a protest against corruption. The success of the protest in Tunisia gave a domino effect to the surrounding countries. The impact of the Arab Spring also occurred in Libya in 2011. Libyan leader, Muhammar al-Gaddafi who has been in power for 42 years, refused to resign. This triggered protest from the Libyan people. Civil war happened in Libya between the pro-Gaddafi group and the opposition. NATO conducted humanitarian intervention in Libya under the official UN mandate. This article provides a humanitarian intervention analysis conducted by NATO using just war theory, especially the principle of jus in bello. The purpose of this article is to find out whether the intervention was in accordance with the jus in bello principle or not. This article used the literature study method by collecting data related to NATO intervention in Libya. This article shows that there are crimes against humanity committed by NATO in Libya. But, NATO intervention in Libya can reach the goal if viewed with proportionality principle in jus in bello. Keywords: Libyan conflict, humanitarian intervention, jus in bello.
DEMYSTIFYING THE MYTH OF COSMOPOLITANISM: ARE WE TRULY LIVING IN A BORDERLESS WORLD?
Authors: Rivai Aspin Nur Arifin , Bastari Gema Ramadhan 
Published: February 2021

This paper will discuss about the possibility that cosmopolitanism as an idea might only exist as a myth. It begins by questioning the hypocrisy surrounding our everyday life where powerful countries preach about living in dignity but ended up taking away that very dignity itself. If cosmopolitanism is defined as an idea that give worth to every human being, no matter their affiliation, then the current state of the world does not reflect that idea at all. This paper will attempt to demystify the practice of cosmopolitanism in modern era. This paper then found that cosmopolitanism is basically a political project for the powerful to inject their idea into weaker actor, in order to create hegemony. Whether someone’s act can be considered cosmopolitan or not depends on their capability to exercise their power. In the end, this paper concludes that cosmopolitanism as a standard of morality does not exist in our world. A borderless world might exist, but it is up to the powerful to decide who can live in it. For most people, cosmopolitanism remains a myth that could never bring salvation. Kata kunci: Cosmopolitanism, Morality, Hegemony.
ANALISIS PERLINDUNGAN MEREK DAGANG TERHADAP SENGKETA NEGARA ISLE OF MAN DAN WEN KEN DRUG CO. PTE LTD
Authors: Luneto Riska , Dika Aldilla 
Published: February 2021

Protection of trademarks (goods / services) is one of the important things for every inventor. The success of the WTO as an organization that oversees cooperation in the field of trade has an important role in the struggle that was resolved in the field of trade, in accordance with the agreement in the TRIPs which discussed Intellectual Property that was sponsored both nationally and internationally. The damaged trademark case by the Wen Ken Group Company later became an example of violation of the agreement, when the trademark product / service that was registered did not conflict with the logo, symbol or symbol of an ideology or the State. The resolution of this dispute is then still a polemic in Indonesia because the decisions made are not in accordance with the provisions in force, so they are approved by the WTO. Keywords: Intellectual Property Rights, WTO, TRIPs, Trademarks, Disputes
Theory and Practice of Neuromarketing: Analyzing Human Behavior in Relation to Markets
Authors: Bočková Kateřina , Škrabánková Jana , Hanák Michal 
Published: February 2021

The presented paper deals with a comprehensive interpretation of the term neuromarketing, as a discipline that applies neuroscientific methods to analyze and to understand human behavior in relation to markets and market exchanges. Due to the topic, this paper presents mainly secondary data, next the questionnaire is used. We state that neuromarketing is a discipline that applies neuroscientific methods to analyze and to understand human behavior in relation to the markets and market exchanges. Each of the neuromarketing techniques measures different data and suits different purposes, with a combination of the most reliable results. The interest in the theoretical research of neuromarketing focuses on the consumer decision-making process. One of the main benefits of neuromarketing is the potential to measure accurate, objective data that can be used to make informed decisions in management practice. However, it is currently only a complement to other areas of marketing and will be beneficial if it is used to obtain otherwise inaccessible data. We are convinced that the existence of the Neuromarketing Center in the ITI of the Olomouc agglomeration will be a significant contribution to the development of the neuromarketing theory. Doi: 10.28991/esj-2021-01256 Full Text: PDF