bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water Quality Monitoring System for Fisheries using Internet of Things (IoT)
Authors: Ya’acob N , Dzulkefli N N S N , Yusof A L , Kassim M , Naim N F , Aris S S M 
Published: October 2021

Abstract
Fish production has significant impacts on the investment and operating costs of the modernization of fish ponds. Water quality monitoring system may help to overcome all the problems by using the implementation of the internet of things (IoT) technology. The project aims in detecting the presence of fishes using an ultrasonic sensor and investigating the parameters of pH and temperature sensors. The system is used pH and temperature sensor as the factors affecting the quality of water and fish growth, the ultrasonic sensor for detecting the presence of fishes, Blynk application through a smartphone for notifications, NodeMCU ESP8266 as its central controller and wireless fidelity (WI-FI) as the communication technology. A sample of three different measurement times in the early morning, midday, and evening based on temperature, pH levels and the fish distance show that this farm has high-quality water. From the measurement at the field test, temperature value increase in the midday, pH level remains constant in the three different times and the fish distance underwater always changes as a fish needs to find oxygen and a portion of food. As a result, a farmer need not hire workers at their site, consequently, drive down operating costs and improve efficiency.
Portable Real-Time BMI Nutritional Advice
Authors: Karim A D Ab , Lazam N A Md , Mohd Yahya N A , Abdul Rahman S 
Published: October 2021

Abstract
Overweight and obesity refer to body weight that is greater than what is considered normal or healthy for a certain height. Your body mass index (BMI) is one way to tell if you are at a healthy weight, overweight, or obese. The BMI is a measure based on your weight in relation to your height. Existing device only measure weight and height require the user to self-calculate their BMI based on the formula related to their weight and height. Furthermore, currently available systems cannot keep track user’s previous BMI record and do not provide a guidance or nutritional advice based on user’s current BMI. The solution to this is a proposed project which is an IOT based Portable Real-Time BMI nutritional advice that able to calculate user’s BMI and keep current and previous user’s record. The project aims to help people to monitor their BMI as a way of keeping a healthy weight. The objectives of this project are to develop a portable real-time measuring system to measure height and weight that can auto-calculate BMI and give nutritional advice using web-based application. The sensors used in this system are HX711 Load cell amplifier and Ultrasonic sensor. The system will perform weight and height measurement upon user’s command. Data from both sensors will be sent to NodeMCU Wi-Fi module for BMI calculation. Virtual server is used to store the data from the system app. Apart from BMI calculation, this system is able to display user’s previous BMI data as a performance tracker in monitoring their BMI. The application is also able to generate a nutritional advice based on user’s current BMI.
Students’ Performance Prediction using Artificial Neural Network
Authors: Ahmad N , Hassan N , Jaafar H , Enzai N I M 
Published: October 2021

Abstract
This paper proposed a method for predicting diploma students’ performance of Faculty of Electrical Engineering (EE), Universiti Teknologi MARA (UiTM) Terengganu. Data of 59 first semester students from Electrical Engineering (EE) were obtained to predict students’ academic performance. A predictive model based on a machine learning technique was employed. The predictive model utilizes Artificial Neural Network (ANN) technique that was developed to predict the actual performance of first semester students based on Sijil Pelajaran Malaysia (SPM) results, first semester results, and the interest level of the participants towards EE course. The findings have shown that the developed model could accurately predict the actual result of the first semester students successfully with minimal errors.
Semiconductor defect classification by using cascaded convolutional neural network
Authors: Tajudin P N A , Shapiai M I 
Published: October 2021

Abstract
The semiconductor industry is one of the rapidly growing industries globally. To be on par in both quality and quantity, most of the semiconductor industry has an inspection procedure in line with every production process. The dataset defect classes’ main features can be group into two main groups base on their pattern similarity. Previously, most of the studies did not consider the pattern similarity and fed all the input into one classifier, increasing the risk of misclassification into more classes. One classifier does not feed all. Therefore, this study proposed a cascaded convolutional neural network classifier framework for semiconductor defects to enhance the defect pattern analysis. The cascaded convolutional neural network consists of multiple models trained based on various pre-process inputs. The data pre-processing includes a median filter method by using the OpenCV library. The input has to be pre-processed to distinguish the main feature, and the model can classify it based on those features. Comparing the proposed method with the single classifier show a slight increase in accuracy from 86.7% to 87.7%. In the future, further investigation will be carried out, especially on certain defect wafer compromise of multiple defect classes and how does it reduce the capability of the cascaded convolutional neural network model.
Production and Characterisation of Cheddar Cheese-like from Cocos Nucifera L.
Authors: Ismail S N , Latip M S A , Mohamad M A 
Published: October 2021

AbstractTraditionally, cheese is made from animal milk and had been introduced a long time ago. The increasing demand for cheese has caused a substantial commercialise production that led to animal exploitation and environmental pollution. Henceforth, this study aims to produce and characterise Cheddar Cheese-like attributes made of coconut cream fromCocos Nucifera L.The shelf life analysis, colour analysis used Chroma Meter CR-410, pH value analysis, meltability analysis, and sensory evaluation were conducted through the meltability test, descriptive test, paired comparison test and a consumer preference test. The results illustrated that shelf life is extended below danger zone temperature, and there is a distinct colour of Cheddar Cheese-like colour compared to regular cheese. The Cheddar Cheese-like managed to mimic the effect of melting cheese and was accepted by most of the respondents based on the appearance (93.3 per cent), aroma (86.7 per cent), taste (93.3 per cent), texture (73.3 per cent), and consistency (86.7 per cent) characteristic. Subsequently, preferences analysis shows 56.7 per cent of the respondents prefer Cheddar Cheese-like over the regular cheese. Therefore, based on the result, this study concludes that coconut milk can be an alternative to producing a cheese-like product that will benefit the consumer of different diet and allergies and at the same time preserve the environment for sustainability reason.
Improving pediatric pharmacy services in a primarily adult emergency department
Authors: Hachem Souheila N , Thomson Julie M , Heigham Melissa K , MacDonald Nancy C 
Published: October 2021

Abstract

Purpose
The American Society of Health-System Pharmacists (ASHP) and Pediatric Pharmacy Advocacy Group (PPAG) guidelines for providing pediatric pharmacy services in hospitals and health systems can be used to improve medication safety wherever pediatric patients receive care, including in the emergency department (ED). The purpose of this initiative was to improve compliance with these guidelines in a primarily adult ED.

Methods
This quality improvement initiative was conducted in a level 1 trauma center ED between October 2019 and March 2020. The ASHP-PPAG guidelines were used to create practice elements applicable to the ED. An initial compliance assessment defined elements as noncompliant, partially compliant, fully compliant, or not applicable. Investigators identified interventions to improve compliance for noncompliant or partially compliant elements and then reassessed compliance following implementation. Data were expressed using descriptive statistics. This initiative was exempt from institutional review board approval.

Results
Ninety-three ED practice elements were identified within the 9 standards of the ASHP-PPAG guidelines. At the initial compliance assessment, the majority (59.8%) of practice elements were fully compliant; however, various service gaps were identified in 8 of the standards, and 16 interventions were implemented to improve compliance. At the final compliance assessment, there was a 19.5% increase in full compliance. Barriers to achieving full compliance included technology restrictions, time constraints, financial limitations, and influences external to pharmacy.

Conclusion
This quality improvement initiative demonstrated that the ASHP-PPAG guidelines can be used to improve ED pediatric pharmacy services in a primarily adult institution. The initiative may serve as an example for other hospitals to improve compliance with the guidelines.
Short-term outcomes after pancreatoduodenectomy in octogenarians: multicentre case–control study
Authors: Attard Joseph A , Al-Sarireh Bilal , Bhogal Ricky Harminder , Farrugia Alexia , Fusai Giuseppe , Harper Simon , Hidalgo-Salinas Camila , Jah Asif , Marangoni Gabriele , Mortimer Matthew , Pizanias Michail , Prachialias Andreas , Roberts Keith J , Sew Hee Chloe , Soggiu Fiammetta , Srinivasan Parthi , Chatzizacharias Nikolaos A 
Published: October 2021

Abstract

Background
Pancreatoduodenectomy (PD) is frequently the surgical treatment indicated for a number of pathologies. Elderly patients may be denied surgery because of concerns over poor perioperative outcomes. The aim of this study was to evaluate postoperative clinical outcomes and provide evidence on current UK practice in the elderly population after PD.

Methods
This was a multicentre retrospective case–control study of octogenarians undergoing PD between January 2008 and December 2017, matched with younger controls from seven specialist centres in the UK. The primary endpoint was 90-day mortality. Secondary endpoints were index admission mortality, postoperative complications, and 30-day readmission rates.

Results
In total, 235 octogenarians (median age 81 (range 80–90) years) and 235 controls (age 67 (31–79) years) were included in the study. Eastern Cooperative Oncology Group performance status (median 0 (range 0–3) versus 0 (0–2); P = 0.010) and Charlson Co-morbidity Index score (7 (6–11) versus 5 (2–9); P = 0.001) were higher for octogenarians than controls. Postoperative complication and 30-day readmission rates were comparable. The 90-day mortality rate was higher among octogenarians (9 versus 3 per cent; P = 0.030). Index admission mortality rates were comparable (4 versus 2 per cent; P = 0.160), indicating that the difference in mortality was related to deaths after hospital discharge. Despite the higher 90-day mortality rate in the octogenarian population, multivariable Cox regression analysis did not identify age as an independent predictor of postoperative mortality.

Conclusion
Despite careful patient selection and comparable index admission mortality, 90-day and, particularly, out-of-hospital mortality rates were higher in octogenarians.
A perspective on the centre-periphery hypothesis: some examples inPetuniaand other Neotropical taxa
Authors: Freitas Loreta B 
Published: October 2021

AbstractThe Neotropical region holds high plant species richness, and these species originated under the influence of climate changes, tectonic processes and ecological factors. Several genera of Solanaceae have appeared and diversified quickly in the area, producing a high number of species and lineages. Petunia is endemic to the grasslands of southern South America and constitutes one of these young groups. From this perspective, I aim to identify processes driving the diversification of Petunia, review works describing genetic and morphological diversity for species in this genus and compare the evolutionary patterns of this genus with other genera from the Neotropics. The primary process explaining the genetic variability in the genus seems to be migration during the Quaternary period, as observed for other herbaceous species in South America. Molecular, morphological and even mating system diversity seem to follow the centre-periphery hypothesis.
Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis
Authors: Binsker Ulrike , Käsbohrer Annemarie , Hammerl Jens A 
Published: October 2021

Abstract
The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in the veterinary medicine since its discovery, leading to a steadily increasing prevalence of resistant isolates in the livestock and meat-based food sector. Consequently, transmission of resistant isolates from animals to humans, acquisition via food and exposure to colistin in the clinic are reasons for the increased prevalence of colistin-resistant Enterobacterales in humans in the last decades. Initially, resistance mechanisms were caused by mutations in chromosomal genes. However, since the discovery in 2015, the focus has shifted exclusively to mobile colistin resistances (mcr). This review will advance the understanding of chromosomal-mediated resistance mechanisms in Enterobacterales. We provide an overview about genes involved in colistin resistance and the current global situation of colistin-resistant Enterobacterales. A comparison of the global colistin use in veterinary and human medicine highlights the effort to reduce colistin sales in veterinary medicine under the One Health approach. In contrast, it uncovers the alarming rise in colistin consumption in human medicine due to the emergence of MDR Enterobacterales, which might be an important driver for the increasing emergence of chromosome-mediated colistin resistance.
Critical discussion on drug efflux in Mycobacterium tuberculosis
Authors: Remm Sille , Earp Jennifer C , Dick Thomas , Dartois Véronique , Seeger Markus A 
Published: October 2021

Abstract
Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important goal of tuberculosis research is to shorten the treatment to reduce the burden on patients, increase adherence to the drug regimen and thereby slow down the spread of drug resistance. Inhibition of drug efflux pumps by small molecules has been advocated as a promising strategy to attack persistent Mtb and shorten therapy. Although mycobacterial drug efflux pumps have been broadly investigated, mechanistic studies are scarce. In this critical review, we shed light on drug efflux in its larger mechanistic context by considering the intricate interplay between membrane transporters annotated as drug efflux pumps, membrane energetics, efflux inhibitors and cell wall biosynthesis processes. We conclude that a great wealth of data on mycobacterial transporters is insufficient to distinguish by what mechanism they contribute to drug resistance. Recent studies suggest that some drug efflux pumps transport structural lipids of the mycobacterial cell wall and that the action of certain drug efflux inhibitors involves dissipation of the proton motive force, thereby draining the energy source of all active membrane transporters. We propose recommendations on the generation and interpretation of drug efflux data to reduce ambiguities and promote assigning novel roles to mycobacterial membrane transporters.
Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation ofOBFC1
Authors: Cardinale Antonella , Cantalupo Sueva , Lasorsa Vito Alessandro , Montella Annalaura , Cimmino Flora , Succoio Mariangela , Vermeulen Michiel , Baltissen Marijke P , Esposito Matteo , Avitabile Marianna , Formicola Daniela , Testori Alessandro , Bonfiglio Ferdinando , Ghiorzo Paola , Scalvenzi Massimiliano , Ayala Fabrizio , Zambrano Nicola , Iles Mark M , Xu Mai , Law Matthew H , Brown Kevin M , Iolascon Achille , Capasso Mario 
Published: October 2021

AbstractThe 10q24.33 locus is known to be associated with susceptibility to cutaneous malignant melanoma (CMM), but the mechanisms underlying this association have been not extensively investigated.We carried out an integrative genomic analysis of 10q24.33 using epigenomic annotations and in vitro reporter gene assays to identify regulatory variants. We found two putative functional single nucleotide polymorphisms (SNPs) in an enhancer and in the promoter of OBFC1, respectively, in neural crest and CMM cells, one, rs2995264, altering enhancer activity. The minor allele G of rs2995264 correlated with lower OBFC1 expression in 470 CMM tumors and was confirmed to increase the CMM risk in a cohort of 484 CMM cases and 1801 controls of Italian origin. Hi-C and chromosome conformation capture (3C) experiments showed the interaction between the enhancer-SNP region and the promoter of OBFC1 and an isogenic model characterized by CRISPR-Cas9 deletion of the enhancer-SNP region confirmed the potential regulatory effect of rs2995264 on OBFC1 transcription. Moreover, the presence of G-rs2995264 risk allele reduced the binding affinity of the transcription factor MEOX2. Biologic investigations showed significant cell viability upon depletion of OBFC1, specifically in CMM cells that were homozygous for the protective allele. Clinically, high levels of OBFC1 expression associated with histologically favorable CMM tumors. Finally, preliminary results suggested the potential effect of decreased OBFC1 expression on telomerase activity in tumorigenic conditions.Our results support the hypothesis that reduced expression of OBFC1 gene through functional heritable DNA variation can contribute to malignant transformation of normal melanocytes.
Potential human immunotherapeutics for plague
Authors: Andrianaivoarimanana Voahangy , Randriantseheno Lovasoa Nomena , Moore Kristoffer M , Walker Nicola J , Lonsdale Steven G , Kempster Sarah , Almond Neil A , Rajerison Minoarisoa , Williamson E Diane 
Published: October 2021

Summary
Two monoclonal antibodies directed to the V antigen of Yersinia pestis have been tested for protective efficacy in a murine model of bubonic plague. Mice were infected with a current clinical isolate from Madagascar, designated Y. pestis 10–21/S. Mab7.3, delivered to mice intra-periteoneally at either 24 h prior to, or 24 h post-infection, was fully protective, building on many studies which have demonstrated the protective efficacy of this Mab against a number of different clinical isolates of Y. pestis. Mab 29.3, delivered intra-peritoneally at either −24 h or +24 h, protected 4/5 mice in either condition; this has demonstrated the protective efficacy of this Mab in vivo for the first time. These results add to the cumulative data about Mab7.3, which is currently being humanized and highlight its potential as a human immunotherapeutic for plague, which is an enduring endemic disease in Madagascar and other regions of Africa, Asia, and South America.
Validation of the Thermo Scientific SureTect™ Campylobacter jejuni, C. coli, and C. lari PCR Kit for the Detection of Campylobacter jejuni, C. coli, and C. lari in Raw Poultry and Ready-to-Cook Poultry Products: AOAC Performance Tested MethodSM 012101
Authors: Faulds Nikki , Evans Katharine , Williams Jessica , Crabtree David , Hughes Annette , Stephenson Patrick , Leak Dean , Sohier Daniele , Palomäki Jukka-Pekka , Bastin Benjamin , Benzinger M Joseph , Agin James 
Published: October 2021

Abstract

Background
The Thermo Scientific SureTect™ Campylobacter jejuni, C. coli, and C. lari PCR Kit is a real-time PCR assay for the detection and differentiation of C. jejuni, C. coli, and C. lari from raw poultry, ready-to-cook poultry products, and environmental samples.

Objective
The Thermo Scientific SureTect Campylobacter jejuni, C. coli, and C. lari PCR Kit was evaluated for AOAC®Performance Tested MethodsSM certification.

Methods
Inclusivity/exclusivity, matrix studies, product consistency and stability, and robustness testing were conducted to assess the method’s performance. In the matrix studies, the method was validated against United States and international reference methods for Campylobacter detection.

Results
There were no statistically significant differences found in the matrix studies between the candidate and reference methods when analyzed by probability of detection. All 52 inclusivity strains and none of the 51 exclusivity strains tested were detected by the assay. Robustness testing demonstrated that the assay gave reliable performance with specific method deviations outside of the recommended parameters, and the real-time stability testing demonstrated that there were no statistically significant differences between kit lots, validating the stated shelf life of the kit.

Conclusion
The data presented support the product claims that the Thermo Scientific SureTect Campylobacter jejuni, C. coli, and C. lari PCR assay is suitable for the detection and differentiation of C. jejuni, C. coli, and C. lari from raw poultry, ready-to-cook poultry products, and environmental samples.

Highlights
Presumptive results can be obtained in as little as 23 h. Microaerophilic incubators are not required for enrichment.
Three-Dimensional Tracking of Multiple Small Insects by a Single Camera
Authors: Chen Ching-Hsin , Chiang Ann-Shyn , Tsai Hung-Yin 
Published: October 2021

Abstract
Many systems to monitor insect behavior have been developed recently. Yet most of these can only detect two-dimensional behavior for convenient analysis and exclude other activities, such as jumping or flying. Therefore, the development of a three-dimensional (3D) monitoring system is necessary to investigate the 3D behavior of insects. In such a system, multiple-camera setups are often used to accomplish this purpose. Here, a system with a single camera for tracking small insects in a 3D space is proposed, eliminating the synchronization problems that typically occur when multiple cameras are instead used. With this setup, two other images are obtained via mirrors fixed at other viewing angles. Using the proposed algorithms, the tracking accuracy of five individual drain flies, Clogmia albipunctata (Williston) (Diptera: Psychodidae), flitting about in a spherical arena (78 mm in diameter) is as high as 98.7%, whereas the accuracy of 10 individuals is 96.3%. With this proposed method, the 3D trajectory monitoring experiments of insects can be performed more efficiently.