bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and Genotyping of Patients with Lysosomal Storage Disease in Malaysia.
Authors: Omar Affandi , Mohamed Rosnani , Nordin Fatimah Diana Amin , Shakrin Norashareena Mohamed , Nasohah Sofwatul Mukhtaroh , Salleh Nor Shuhaili , Azize Nor Azimah Abdul , Wahab Siti Aishah Abdul , Lua Seok Hian , Yakob Yusnita , Jalil Julaina Abdul 
Published: August 2021

Abstract
Background: Lysosomal storage disorders (LSD) are storage disorders involving malfunction of degradation enzymes in lysosome. More than 50 types of LSD have been discovered, which includes the group of mucopolysaccharidoses (MPS), sphingolipidoses, oligosaccharidoses, mucolipidoses, lipoprotein storage disorders, lysosomal transport defects and neuronal ceroid lipofuscinoses and others. The aims of this study were to calculate the birth prevalence and carrier frequency of LSDs in the Malaysian population; to compare our results with reported epidemiologic data from other populations, and to describe the mutation spectrum in Malaysia. From 2008 to 2017, 2.1% (92/4338) suspected patients were diagnosed with LSD. Results: The prevalence of LSD in Malaysia was 1/231,904 live births. The combined prevalence of MPS was 1/292,401 with its subtype of MPS II presented the highest calculated birth prevalence of 1/221,425. Within the group of sphingolipidoses, the combine prevalence was 1/770,777 with Fabry as the most common disorder with calculated prevalence of 1/193,203 followed by metachromatic leukodystrophy (MLD) (1/494,514). MLD is more common among people of Iban ethnicity with the prevalence of 1/6,981. Pompe and mucolipidoses type II are the less common subtypes of LSD with a prevalence of 1/1,694,634 and 1/2,229,516, respectively.Conclusion: Overall, although the prevalence of LSD in Malaysia may be underestimated, the prevalence of MPS is consistent with other reported in East Asian countries.
Identification of Core Predication-Related Candidate Genes in Ovarian Cancer Based on Integrated Bioinformatics and Experienment
Authors: Bi Jiaqing , Qin Qian , Ma Huihan , Ma Meijie , Feng Qinmei 
Published: August 2021

Abstract
Background: Ovarian cancer is one of the deadliest and most common gynecological malignancies. This study aims to use comprehensive bioinformatics analysis to try to identify the core candidate genes related to the prediction of ovarian cancer for the early diagnosis and prognosis of ovarian cancer. Methods: Obtain expression profiles from Gene Expression Omnibus database, identify differentially expressed genes (DEG) with p<0.05 and (logFC)>1.5, perform functional enrichment, protein-protein interaction (PPI) network construction, functional module analysis, and survival analysis And correlation analysis to obtain the target gene, through immunohistochemical staining, clinicopathological feature analysis to verify the expression and clinical significance of TTK.Results: 1. Identified 135 genes with the same expression. 33 up-regulated DEG were mainly enriched in mitotic spindle assembly checkpoints, chromosome segregation regulation, etc.; 102 down-regulated DEG was mainly enriched in neurotransmitter level regulation, protein serine/threonine Regulation of acid kinase activity, etc. Then the PPI network was constructed to screen 20 hub genes and perform survival analysis and expression correlation analysis. At the same time, the modules that met the requirements were screened and the genes were analyzed by pathway enrichment. It was found that TTK was highly expressed in ovarian cancer and led to a poor prognosis.2. Distant metastasis, lymph node metastasis, clinical staging (stage III-IV), and poor differentiation are independent risk factors for high TTK expression (P<0.05).3. TTK, CA125, HE4 three biological indicators show excellent diagnostic value in joint monitoring of ovarian cancer.Conclusions: TTK plays a vital role in the tumorigenesis, aggressiveness and malignant biological behavior of EOC, and can be used as a potential biomarker and potential therapeutic target for early diagnosis and predictive evaluation of EOC.
Stunting and Associated Factors Among Children Aged 6-59 Months From Households in Productive Safety Net Program and Non-productive Safety Net Program in Meta District, East Hararghe Zone, Eastern Ethiopia: a Comparative Cross – Sectional Study.
Authors: Tesfaye Aklilu , Egata Gudina 
Published: August 2021

Abstract
Background: Undernutrition is one of the major public health problems affecting children in developing settings. Despite impressive interventions such as productive safety net program (PSNP) in Ethiopia, there is paucity of information on the prevalence of stunting and its predictors among children aged 6-59 months born to beneficiaries and non-beneficiaries of the program in Ethiopia. Methods: Community based comparative cross sectional study design was used among randomly selected 1555 children aged 6 to 59 months from households using and not using PSNP respectively in Meta distinct from 5th-20th of March, 2017. Data were collected using pre-tested structured questionnaire. Measuring board was used to measure the length/height of the children. Length/height for age z-score was generated using world Health Organization (WHO) Anthros version 3.2.2. Descriptive statistics was used to describe all relevant data. Bivariable and Multivariable logistic regression analyses were used to predictors of the outcome variable. Odds ratio along with 95% confidence interval were estimated to measure the strength of the association. Level of statistical significance was declared at p-value less than 0.05. Result: The prevalence of stunting was 47.7%, 95% CI: (44.1%, 51.5%) among children from PSNP beneficiary households and 33.5%, 95% CI: (29.9%, 36.9%) from non-PSNP households respectively. Lack of maternal education [AOR = 3.39; 95% CI: (1.12, 5.11)], lack of women’s empowerment [AOR= 3.48; 95% CI: (2.36, 5.12)], non-attendance of antenatal care fourth visit [AOR= 4.2, 95% CI (2.5, 6.8)], practicing hand washing [AOR= 0.46; 95% CI: (0.28, 0.76)], childhood illness [AOR= 8.41; 95%CI: (4.58, 12.76)], non-exclusive breastfeeding [AOR= 3.6; 95% CI: (2.30, 4.80)], low dietary diversity score [AOR= 4.7; 95% CI (3.0, 7.40)] , and child ‘s age between 24 to 59 months [AOR = 3.2; 95% CI (1.6, 6.3)] were predictors of stunting. Conclusions: The prevalence of stunting was high among children from PSNP households in the study area. Stunting was significantly associated with maternal socio-demographic and obstetric and child related factors. Therefore, empowering women on household’s issues and improving infant and young child feeding practices could reduce the magnitude of stunting and its impacts on child health.
Reliability and Power Analysis of FinFET Based SRAM
Authors: Navaneetha Alluri , Bikshalu K. 
Published: August 2021

Abstract
Demand for accommodating more and new functionalities within a single chip such as SOC needs a novel devices and architecture such as FinFET device instead of MOSFET. FinFET is emerged as non-planar, multigate device to overcome short channel effects such as subthreshold swing deterioration, drain induced barrier lowering, threshold voltage roll off which degrade circuit performance. As the need of device technology is mounting in electronic gadgets the important parameters are taken into consideration such as low leakage, high reliability, low power dissipation, and high operating speed. Reliability is one of key considerations in converting a proof of concept into reality. In this work Reliability of FinFET device is studied experimentally according to ITRS (international technology roadmap for semiconductor) roadmap using several standard test protocols such as multiple current stressing, harsher environment conditions, and effect of electromigration. Furthermore, power analysis of FinFET based SRAM is done by using 7nm bsimcmg PTM files in mentor graphics tool. The FinFET based SRAM shown low leakage, power dissipation, delay compared to existing conventional MOSFET based SRAM.
Role of survival-associated alternative splicing events in the prognosis of ovarian cancer
Authors: Yue Congbo , Zhao Tianyi , Zhang Shoucai , Liu Yingjie , ZHENG GUIXI , Zhang Yi 
Published: August 2021

Abstract
Objective

Alternative splicing (AS) events play a crucial role in the tumorigenesis and progression of various cancers. In the present study, we aimed to identify specific AS events, which might be prognostic markers and therapeutic targets for ovarian cancer (OV).
Methods

Transcriptome data, clinical information, and Percent Spliced In (PSI) values were downloaded from TCGA database and TCGA SpliceSeq to explore the role of AS events in the prognosis of OV patients. Univariate and multivariate Cox regression analyses were performed to identify survival-associated AS events and develop multi-AS-based prognostic models. The K-M curves and ROC curves were conducted based on prognostic AS event models. Moreover, a splicing regulatory network was established according to the correlation between AS events and splicing factors (SFs). Finally, we performed functional enrichment analysis by GO terms and KEGG pathways.
Results

We identified 1,472 AS events that were associated with the survival of OV patients, and exon skipping (ES) was the most important type. We also found that prognostic models based on AS events were good predictors of OV prognosis, which could discriminate the high-risk group from the low-risk group (P < 0.05). Notably, the AUC value of AD, AP, AT, ES, ME, and the whole cohort was more than 0.70, indicating that these six models had valuable prediction strength. The risk score of prognostic models was identified as an independent prognostic factor. Furthermore, the AS-SF correlation network revealed several hub SF genes, including DDX39B, PNN, LUC7L3, ZC3H4 and SRSF11, and so on.
Conclusions

In the present study, we constructed powerful prognostic predictors for OV patients and uncovered interesting splicing networks. Collectively, our findings provided valuable insights into the underlying mechanisms of OV.
Safety of Bedside Placement of Tunneled Hemodialysis Catheters In The Intensive Care Unit: Translating From The Covid-19 Experience – Retrospective Single-Center Case Series
Authors: Sohail Mohammad Ahsan , Hanane Tarik , Lane James , Vachharajani Tushar 
Published: August 2021

Abstract
Background: Critically-ill patients with coronavirus disease-2019 (COVID-19) and kidney dysfunction often require tunneled hemodialysis catheter (TDC) placement for kidney replacement therapy (KRT), typically under fluoroscopic guidance to minimize catheter-related complications. This entails transportation of patients outside the intensive care unit (ICU) to a fluoroscopy suite, which may potentially expose many healthcare providers to COVID-19. One potential strategy to mitigate the risk of viral transmission is to insert TDCs at the bedside, using ultrasound (US) and anatomic landmarks only, without fluoroscopic guidance. Methods: We reviewed all COVID-19 patients in the ICU who underwent right internal jugular (RIJ) TDC insertion at the bedside between April and December 2020. Outcomes included procedural complications such as bleeding, venous air embolism, arrhythmias, pneumothorax and catheter tip malposition. TDC insertion was considered successful if the catheter was able to achieve blood flow sufficient to perform a single hemodialysis treatment. Results: We report a retrospective single-center case series of 25 patients with COVID-19 who had RIJ TDCs placed at the bedside, 10 of whom underwent simultaneous insertion of small-bore RIJ tunneled central venous catheters (T-CVC). Continuous veno-venous hemodialysis was the KRT modality employed in all patients. A median catheter blood flow rate of 200 ml/min (IQR:200-200) was achieved in all patients without any deviation from the dialysis prescription. No catheter-related complications were observed and none of the catheter tips were mal-positioned. Conclusions: Bedside RIJ TDC placement in COVID-19 patients, using US and anatomic landmarks without fluoroscopic guidance, may potentially reduce the risk of COVID-19 transmission amongst healthcare workers without compromising patient safety or catheter function.
Methanol-Based Esterification of Palm Oil Sludge – Preparation of Palmitic and Oleic Fatty Acid Ethyl Esters via Ethyl Acetate Transesterification
Authors: CHAPARRO-ACOSTA Javier , URBINA-GONZÁLEZ Juan-Manuel 
Published: August 2021

Abstract
Acid-catalyzed Fischer esterification of fatty acids with methanol as a reagent and solvent is used to prepare long chain alkyl methyl esters. Transesterification of palm oil in basic media using methanol is a synthesis route to prepare monoalkyl methyl esters of fatty acids. In this work, we report performing Fischer esterification of a sample of local palm oil sludge (rich in fatty acids) in the presence of methanol and obtaining ethyl esters of oleic and palmitic acids from transesterification reactions during extractions with ethyl acetate.
Sociocultural drivers of spirituality in Indian Saints; A Principal Component Analysis.
Authors: Mishra Prof. Badrinarayan 
Published: August 2021

Abstract
Human health is multidomain. However, the physical component has dominated health research. Spiritual health, the component traditionally considered as the pivot for health and wellness has taken a back seat. Exploring its’ different determinants in the traditional preachers will enhance our understanding of them and will be a guide for their use in the common man’s life. Aim: To find out important sociocultural factors/drivers to the spiritual health in Indian Saints. Objectives: To identify the important social and cultural determinants of spirituality in the study group by factor extraction through Principal Component Analysis (PCA). Methodology: 958 connecting Indian Saints who congregated at Kumbh Mela at the holy city of Ujjain in 2016 were randomly selected in equal proportion from different sects(clans). Their sociocultural background and spiritual score were evaluated by a sociocultural questionnaire and SAI (Spiritual Assessment Inventory). The contribution of sociocultural factors to spiritual score was analysed by Principal Component Analysis (PCA) and linear regression modelling. Statistical significance was established at p < 0.05. Results: 20 sociocultural factors were evaluated for component loading (factor extraction) and their impact on the spiritual score. The KMO (Kaiser-Meyer-Olkin Measure) score of Sampling Adequacy, Bartlett's test of sphericity and Communalities extraction were 0.57, sig. of 0.00 and ≥ 0.4 respectively thereby supporting; factor analysis. On PCA 6 had an eigenvalue > 1. All of these 6 principal components were found maintainable on The Monte Carlo PCA for Parallel Analysis and they together explained 66.20% of the cumulative variance. Their respective taxonomies were emancipation (PC 1), family heritage (PC 2), stimuli (PC 3), faith (PC 4), education (PC 5), and self-hegemony (PC 6). On regression analysis, the four important influencers of spirituality were; participant’s origin from a joint family (p – 0.00), their daily routine for spiritual enhancement (p-0.01), respect for other religions (p-0.00), and self-motivation (p-0.01). Conclusion: Emancipation (freedom from family bondage), the presence of religious family background, a fixed daily routine, belief in all religions, an unremitting drive for spiritual education, and self-hegemony were dominant components that determined spirituality in Indian Saints. Translating these drivers for the benefit of commoners may enrich their overall health and wellness.
The visual encoding of graspable unfamiliar objects
Authors: Federico Giovanni , Osiurak François , Brandimonte Maria Antonella , Salvatore Marco , Cavaliere Carlo 
Published: August 2021

Abstract
We explored by eye-tracking the visual encoding modalities of participants (N = 20) involved in a free-observation task in which three repetitions of ten unfamiliar graspable objects were administered. Then, we analysed the temporal allocation (t = 1500ms) of visual-spatial attention to objects’ manipulation (i.e., the part aimed at grasping the object) and functional (i.e., the part aimed at recognizing the function and identity of the object) areas. We found a reversed quadratic trend in the way participants visually explored the objects. Within the first 750ms, participants tended to shift their gaze on the functional areas while decreasing their attention on the manipulation areas. Then, participants reversed this trend, decreasing their visual-spatial attention to the functional areas while relatively increasing fixations to the manipulation areas. Crucially, the global amount of visual-spatial attention for objects’ functional areas significantly decreased as an effect of stimuli repetition while remaining stable for the manipulation areas, thus indicating stimulus familiarity effects. These findings support the action reappraisal theoretical approach, which considers object processing and tool use as abilities emerging from the integration among semantic, technical/mechanical, and sensorimotor knowledge.
Silver decorated myconanoparticles control growth and biofilm formation in uropathogenic E. coli
Authors: S Ranjani , U U. Rubiya Kathun , Hemalatha S 
Published: August 2021

Abstract
Nanotechnology involves the synthesis of nanoparticles that has been used in therapeutic application for treating diseases. In this present study we have adopted the synthesis of myconanoparticles from the extracellular extract of endophytic fungi Penicillium sclerotiorum (PsNps) and validated for its antibacterial potential against antibiotic resistant uropathogenic E. coli and ATCC (25922) strain of E. coli. Endophytic fungi were isolated from the healthy leaves of Tamarindus indica. The genomic DNA from endophytic fungi was isolated and ITS region was amplified by polymerase chain reaction (PCR) using universal fungal primers ITS1 and ITS4and sequenced for the identification of endophytic fungal isolates. Penicillium sclerotiorum extract were used for the synthesis silver nanoparticles (PsNps) and were characterized by UV-Vis spectroscopy, Fourier transform- infrared spectroscopy (FTIR), Zeta potential, FE-SEM and Energy- Dispersive X-ray analysis (EDAX). Antibacterial activity of PsNps was tested against the antibiotic resistant uropathogenic E. coli and ATCC (25922) strain of E. coli. Further experiments were carried out to explore the potential of PsNps in regulating the CTX-M-15 gene. The antimicrobial activity showed that the PsNps inhibited growth, biofilm formation in both the strains of E. coli. The expression of gene encoding CTX-M-15 was down regulated in resistant strain of uropathogenic E. coli. Our results suggest that the PsNps could be used as an alternative source for the antibiotics. Thus, further studies can be conducted to prove the in vivo potential of PsNps and can be formulated for commercialization.
An alternative approach to the relation between accretion luminosity and mass accretion rate
Authors: Pezzuto Stefano 
Published: August 2021

Abstract
In this paper I introduce and discuss an alternative approach to the relation between accretion luminosity, Lacc, and mass accretion rate, ˙M : instead of the universally adopted Lacc = GM ˙M/R, I propose the dynamical definition Lacc = v2f˙M/2 where vf is the final velocity of the infalling matter at the surface of the accreting object of mass M and radius R. Both definitions are based on the energy conservation, but while the former assumes that matter is in free fall, the latter is valid always. By adopting the alternative form for Lacc, I show that the Eddington luminosity Led, when the outward radiation pressure wins on gravity, is never produced with a finite ˙M. Instead, Led is a limit asymptotically reached when ˙M → ¥. My argument is very simple, so I felt the need to find a possible explanation to why no one arrived to this conclusion before. To this aim, I give a brief presentation of the history of accretion, from the pioneer work of Hoyle and collaborators until the ’60s of last century, to show how the perception of the role of the radiation pressure in accretion evolved. I give also some practical applications of the formulae I derived, in the case of high-mass star formation and of the growth of super massive black holes. The study of these two processes, already complex per se, becomes more difficult to solve because of the existence of a limiting ˙M, named Eddington mass accretion rate or ˙Med, that it is supposed to generate a luminosity equal to Led, making it impossible to accrete at rate ˙M > ˙Med. Accretion rates higher than ˙Med are however necessary, as theory and observations show. My definition of Lacc takes naturally into account the work done by radiation pressure to slow down the infalling matter: as a consequence, Lacc does not increase linearly with ˙M and Led is only an asymptotic value.
Contribution of reduced graphene oxidetohemicelluloses-basedfilms with enhanced mechanical and conductivity properties
Authors: Wu Yule , Rao Jun , Peng Feng , Zhang Liping , Gao Hui , Guan Ying 
Published: August 2021

Abstract
Aquaternized hemicellulose (QH)/chitosan/reduced graphene oxide (rGO) composite film with good mechanical propertyand electrical conductivity was prepared bysolution-casting method. The effects of reduced graphene oxide contents on the structures and properties of the composite films were investigated.The mechanical property and electrical conductivity of the film with rGO containing 0.5 wt.% was reached 102.09 MPa and 12.8 × 10− 2 S/cm, respectively.Under the functions of hydrogen bonds and Van Der Waals forces, three components were combined to obtain QH/CS/rGO composite films with higher thermal stability and conductivity. Due to the compositing of rGO, the composite films showed good UV-blocking properties.This work provided a low-cost and sustainable pathway for the application of high-strength hemicellulose composite films with electrical conductivity and UV resistance in flexible electrode materials.
Upgraded valorization of copper (II) immobilization onto Schiff base-functionalized pectin grafted magnetic nanoparticles: A thermostable, reusable, and efficient nanocatalyst for the green synthesis of 1,2,3-triazole in pure water
Authors: Siuki Hossein Khashei , Kargar Pouya Ghamari , Bagherzade Ghodsieh 
Published: August 2021

Abstract
In this project, the new catalyst copper defines as Fe3O4@Pectin@(CH2)3-Acetamide-Cu(II) was successfully manufactured and fully characterized by different techniques, including FT-IR, XRD, TEM, FESEM, EDX, VSM, and ICP analysis. All results showed that copper was successfully supported on the polymer‐coated magnetic nanoparticles. One of the most important properties of a catalyst is the ability to be prepared from simple materials such as pectin that’s a biopolymer that is widely found in nature. The catalytic activity of Fe3O4@Pectin@(CH2)3-Acetamide-Cu(II) was examined in a classical, one pot, and the three-component reaction of terminal alkynes, alkyl halides, and sodium azide in water and observed, proceeding smoothly and completed in good yields and high regioselectivity. The critical potential interests of the present method include high yields, recyclability of catalyst, easy workup, using an eco-friendly solvent, and the ability to sustain a variety of functional groups, which give economical as well as ecological rewards. The capability of the nanocomposite was compared with previous works, and the nanocomposite was found more efficient, economical, and reproducible. Also, the catalyst can be easily removed from the reaction solution using an external magnet and reused for five runs without reduction in catalyst activity.