bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endogenous N-oleoylethanolamine Crystals loaded Liposomes with Enhanced Hydrophobic Drug Loading Capacity for Efficient Stroke Therapy
Authors: Wu Shichao , Liao Di , Li Xi , Liu Zeyu , Zhang Lin , Mo Fanny , Hu Shuo , Xia Jian , Yang Xiangrui 
Published: July 2021

Abstract
Background. Although the preparation of liposomes achieves great success and many have received regulatory approval, their retention of highly hydrophobic drugs is still problematic. Results. Herein we report a novel strategy for efficiently loading hydrophobic drug to liposomes for stroke therapy. N-oleoylethanolamine (OEA), an endogenous highly hydrophobic molecule with outstanding neuroprotective effect, was successfully loaded to OEA-SPC&DSPE-PEG liposomes (OSDP LNPs) with a drug loading of 15.9 ± 1.2 wt%, four times higher than those prepared via traditional methods. Efficient retention in OSDP LNPs greatly improved the pharmaceutical property and therefore enhanced the neuroprotective effect of OEA. Through the data of positron emission tomography (PET) and TTC-stained brain slices, it could be clearly visualized that the acute ischemic brain tissues were preserved as penumbral tissues and bounced back with reperfusion. The in vivo experiments stated that OSDP LNPs could significantly improve the survival rate, the behavioral score, the spatial learning and memory ability of the MCAO (middle cerebral artery occlusion) rats. Meanwhile, the cerebral infarct volume, the edema degree, the apoptosis of the neurons and the inflammation within the brain were also greatly decreased. Conclusions. These results suggest that the OSDP LNPs have a great chance to develop hydrophobic OEA into a potential anti-stroke formulation.
Impact of Mild to Moderate U-shape Hearing Loss on Listening Effort in School-aged Children with Alport Syndrome
Authors: Chen Zhe , Zhang Yue , Zhang Zhikai , Ren Lei , Wei Chaogang , Liu Yuhe 
Published: July 2021

Abstract
In this study, we aimed to investigate the effect of mild to moderate U-shape hearing loss on listening effort in Alport syndrome (AS) children by pupillometry. Subjects were required to answer questions after listening to conversations that simulate real scenes in daily life. We recorded the accuracy rate and pupil data of two conditions: SNR = + 15 dB and SNR = -2 dB. A mixed effect model was established to analyze the influence of SNR, mid-frequency energy proportion and hearing status on the accuracy and pupil response. The results showed SNR had a main effect on the accuracy. The baseline pupil diameter of AS children was always smaller than normal hearing children. When analyzing the time window including the stages of listening to the conversation, listening to the question and thinking, SNR and the hearing status had main effect on mean pupil dilation. We concluded that AS children with hearing loss were often in a state of low arousal before auditory task. Both hearing status and task difficulty have impact on listening effort of AS children. The effort of AS children with U-shape hearing loss might come mainly from consequent cognitive processing (as a consequence of effortful listening) instead of passive listening during speech communication.
Performance Evaluation of Epitaxial Layer Based Gate Modulated TFET (GM-TFET)
Authors: Saha Rajesh , Goswami Rupam , Bhowmick Brinda , Baishya Srimanta 
Published: July 2021

Abstract
This paper reports the performance of an epitaxial layer (ETL) based gate modulated (GM-TFET) through 3D Technology Computer Aided Design (TCAD) simulations. The architecture utilizes effects of both vertical tunneling and lateral tunneling phenomena to improve the device performance. Attributes of the ETL, its thickness (tepi) and doping concentration (Nepi) are varied and their impact on device electrical parameters such as transfer characteristic, output performance, subthreshold swing (SS), and threshold voltage (VT) is highlighted. It is observed that both tepi and Nepi significantly influence the different electrical parameters of the ETL based TFET architecture.
Application of Precut Papillotomy in Patients With Surgically Altered Gastrointestinal Anatomy
Authors: Yin Linlin , Zhao Si , Zhu Hanlong , Ji Guozhong , Zhang Xiuhua 
Published: July 2021

Abstract
It is challenging to perform ERCP (endoscopic retrograde cholangiopancreatography) in patients with surgically altered gastrointestinal anatomy. The failure rate of selective bile duct cannulation by the standard method is high. To explore the application of precut papillotomy (PP) technique in patients with gastrectomy, we carried out this retrospective analysis. From January 2017 to September 2020, 107 patients with surgically altered gastrointestinal anatomy were referred to our department for ERCP examination. Among them, 11 cases were duodenal stricture or jejunal stricture, resulting in the inability to reach the duodenal papilla. Eleven patients stopped cannulation because they could not tolerate the further operation. 60 patients were intubated successfully by standard method. Finally, 25 patients using the precut papillotomy technique were included in our analysis. Of the 25 patients who used pp, 21 completed selective biliary cannulation, with a success rate of 84% (21/25). Compared with standard intubation, the PP technique increased the success rate of intubation in patients with altered anatomy by 21.9%. Among the patients we included, 2 cases had adverse events, including 1 case of acute pancreatitis and 1 case of perforation; the incidence of adverse events was 8%. All adverse events were mild and cured after conservative treatment. In patients with gastrointestinal anatomical changes, PP is effective and relatively safe to improve the selective biliary cannulation success rate.
Birth weight and nutrient restriction affect jejunal enzyme activity and gene markers for nutrient transport and intestinal function in piglets
Authors: Wellington Michael O. , Rodrigues Lucas A. , Li Qiao , Dong Bingqi , Panisson Josiane C. , Yang Chengbo , Columbus Daniel 
Published: July 2021

Abstract

Background
Significant variations in live birth weight of piglets have arisen due to increased sow prolificacy. Intestinal development and function may be affected by birth weight. Low birth weight (LBW) pigs may also have reduced feed intake, leading to further impairment of intestinal development. The objective of this study was to examine the intestinal development pattern of low and normal birth weight (NBW) piglets with normal (NN) or restricted (RN) neonatal feed intake.
Results
Jejunal intestinal samples were analyzed for target gene expression and enzyme activity at d 28 (weaning) 56 post-birth (post-weaning). At d 28, EAAC1 and B0AT1 were downregulated in LBW compared to NBW pigs (P < 0.05). On d 56, B0AT1 and ASCT2 were downregulated in RN compared to NN pigs (P < 0.05), regardless of birth weight. PepT1 expression was downregulated in LBW compared to NBW pigs at 28 d (P < 0.05), with no effects of treatments at 56 d. SGLT1 was upregulated in NBW-NN compared to LBW-NN pigs (P < 0.05) at 28 d. Alkaline phosphatase (ALP) was upregulated in LBW-RN at d 28. At d 56, CLDN-3 and ZO-1 were upregulated in NN compared to RN pigs (P < 0.05). There were no treatment effects on ALP, maltase, or sucrase activity at 28 d. However, at 56 d, ALP was upregulated in NBW-NN pigs while sucrase activity was upregulated in NN pigs.
Conclusion
The results demonstrate differences in jejunal gene expression associated with birth weight, with reduced expression of protein/amino acid transporters (PepT1, EAAC1, B0AT1) in LBW compared to NBW pigs. While neonatal nutrient restriction had minimal effects at 28 d, intestinal barrier function (Claudin-3 and ZO-1) and neutral amino acid transport (B0AT1 and ASCT2) were improved in pigs under normal compared to restricted feeding pre-weaning at d 56.
The Cervantes Scale for Measuring Health-Related Quality of Life in Postmenopausal Breast Cancer Survivors During Adjuvant Endocrine Therapy
Authors: Custódio Isis Danyelle D. , Mazzutti Fernanda S. , Lima Mariana T. M. , de Carvalho Kamila P. , Canto Paula P. L. , Paiva Carlos Eduardo , Maia Yara Cristina de Paiva 
Published: July 2021

Abstract
Background: Potentially, instruments to manage adverse effects may improve adherence and persistence of treatment, health-related quality of life (HRQL) and breast cancer (BC) outcomes. In this sense, we consider the Cervantes Scale an appropriate option to assess HRQL in BC survivors undergoing adjuvant endocrine therapy with Aromatase Inhibitors (AI), as it is a specific HRQL questionnaire that considers particularities of the perimenopausal and postmenopausal women. The purpose of this study was to analyze the psychometric properties of the 31-item Cervantes Scale (CS-31), 16-item Cervantes Short-Form Scale (CS-16) and 10-item Cervantes Scale (CS-10) and to promote the additional validation for breast cancer (BC) survivors during adjuvant endocrine therapy.Methods: This prospective study included 89 postmenopausal BC survivors in endocrine therapy. The women completed the CS, Functional Assessment of Chronic Illness Therapy - fatigue (FACIT-F) and Hospital Anxiety and Depression Scale (HADS). The internal consistency, convergent validity, responsiveness analyses and known-group validity of CS were evaluated. Also, simple linear regression assessed the predictive capacity of the CS in relation to the FACIT-F.Results: The internal consistency was good (Cronbach's alpha: CS-10=0.76; CS-16=0.80; CS-31=0.89). For convergent validity, in general, we identified negative and strong correlations (r>0.6) with exception of moderate correlation between Social/Family Well-Being of FACIT-F and Sexual (r=-0.453) and Couple (r=-0.436) of CS-31, and weak correlation between Social/Family Well-Being of FACIT-F and Sexual (r=-0.289) and Couple (r=-0.287) of CS-16. A prospective improvement in health-related quality of life (HRQL) were identified, except for domains Sexual and Couple of CS-16/CS-31, as well as FACT-G, Social/Family and Functional Well-Being of FACIT-F. The CSs were able to predict changes in the FACIT-F. Furthermore, women with anxiety and depression by HADS presented worse HRQL by CS (p<0.001).Conclusions: We identified that the CS, highlighting the CS-31, proved to be appropriate for use in routine medical oncology with BC survivors during adjuvant endocrine therapy, although larger studies are needed to confirm these results.
MicroRNA-155 Expression Is Associated With Pulpitis Progression By Targeting SHIP1
Authors: Li Baishun , Guo Liyang , He Ying , Tu Xinran , Zhong Jialin , Guan Hongbing , Jiang Yiguo , Jiang Qianzhou 
Published: July 2021

Abstract
Pulpitis is a commonly seen oral inflammation condition in clinical practice, it can cause much pain for the patient and may induce infections in other systems. Much is still unknown for the pathogenic mechanism of pulpitis. In this work, we discovered that the expression of miR-155 was associated with dental pulpal inflammation both in vivo and in vitro. Experiments on odontoblast cell line MDPC-23 showed miR-155 could act as a positive regulator by increasing the production of pro-inflammatory cytokines IL-1β and IL-6 during inflammatory responses, whereas knockdown of miR-155 can reverse the effects. Bioinformatics analysis demonstrated that SHIP1 is a direct target of miR-155 in odontoblasts, this result was further verified at both mRNA and protein level. Inhibition of miR-155 resulted in the downregulation of inflammation factors, while co-transfection of si-SHIP1 and miR-155 inhibitor promoted the inflammatory responses. Treatment with miR-155 mimic or si-SHIP1 up-regulated the protein level of p-PI3K and p-AKT. By contrast, miR-155 inhibitor exerted the opposite effects. miR-155 mimics could upregulated the gene expression of IL-1β and IL-6. Co-transfection of LY294002 and miR-155 mimic attenuated the inflammatory responses. Consistent with in vitro results, miR-155-/- mice could alleviate inflammatory response, as well as decrease the activation of p-PI3K and p-AKT, whereas increase the activation of SHIP1. In conclusion, these data revealed a novel role for miR-155 in regulation of dental pulpal inflammatory response by targeting SHIP1 through PI3K/AKT signaling pathway.
In-Situ Fabrication of ZrB2-ZrC-SiCnws Hybrid Nanopowders With Tunable Morphologies of SiCnws
Authors: Liu Changqing , Yuan Xiaoxiao , Wang Wanting , Liu Hulin , Li Chengxin , Wu Heng , Hou Xianghui 
Published: July 2021

Abstract
SiC nanowires (SiCnws) with different morphologies have great potential for the reinforcement of ceramic materials. But it is a big challenge in the in-situ synthesis of SiCnws in the ceramic powders which is critical to ensure high reinforcing effects. For the reinforcement of ZrB2-ZrC composites, a simple method is developed to in-situ fabricate SiCnws with various morphologies in nano-sized ZrB2-ZrC powders through pyrolyzing ZrB2-ZrC-SiC gel precursors. The prepared ZrB2-ZrC ceramic powders have mean diameter of about 100 nm with uniformly distributed SiCnw in morphologies of nanocylider, bead-like, bamboo-shape with tunable nodes, chain-like and hexagonal prisms were prepared by optimizing the preparation process. Moreover, the SiCnws were in a diameter of ranging from 100 to 400 nm, while the length was controlled from tens to hundreds of microns. The generation of ZrB2/ZrC can determine the formation of SiCnws with specific morphologies by producing CO gas to affect the local supersaturation of the SiO and CO vapors. The study provides an opportunity for fabricating SiCnw reinforced ceramic materials with enhanced strengthening effect and also overcome its critical fabrication process.
Electrical Properties of Double Perovskite LaPbFeTiO6 Synthesized by Sol-Gel Method
Authors: Nassar K. Iben , Slimi M. , Rammeh N. , Graça Manuel. P. F. 
Published: July 2021

Abstract
The double perovskite structure is interesting for many researches in various fields of physics and their technological applications. The LaPbFeTiO6 (LPFTO) compound is a very important for many technologies because it has dielectric and electrical properties. It has made an attractive semiconductor material for the electronic field, such as the realization of filters or capacitors. In this work, LaPbFeTiO6 was prepared by the sol-gel method.The structural, morphological and electrical properties of this sample were studied using different techniques. X-ray diffraction analysis, the sample crystallized in the rhombohedral system with space group R C. The surface of the sample and the average grain size were examined by scanning electron microscope (SEM). The electrical conductivity and dielectric characterizations were studied as a function of frequency and temperature (200-380K) by impedance spectroscopy. Indeed, the dielectric constant increases with increasing temperature. The AC conductivity obeys the Jonscher power law. The activation energy obtained from the complex impedance and the conductivity are close. The frequency dependence of the electrical impedance shows the existence of a relaxation phenomenon.
Advanced Digital Health Care Information Sharing for Covid19- Version 2.0
Authors: yadav Kusum , G Suhasini , Kartha Ranju S , Le Trung-Hieu , M Nazargi Mahabob , Kumar Anil , Bommisetti Ravi kumar 
Published: July 2021

Abstract
The covid-19 virus has been linked to an acute outbreak of the disease that has passed for years. Clear explanations of these should be provided by trained professionals and those with healthcare experience who have the energy to work on intensive care. The World Health Organization (WHO) has taken various steps to address this. These can be audited by NETCCN (National Emergency Telecritical Care Network) using digital technology. This section explains a lot. It is proposed by the National Emergency Telecritical Care Network (NETCCN). This digital health information will be solved as an updated version 2.0, which will greatly improve future emergencies. The proposed method of digital predication support for Artificial Intelligent (AI). Use these to learn historical information about the virus. This technology can detect telemetry, complex maintenance robotics and monitoring intelligence. These can be developed to integrate multiple virus-related information. All of these will be coordinated by health professionals. Frequently testing should be done to ensure continued readiness to protect against emergency disasters.
Determination of laminar burning velocity of methane/air flames in sub atmospheric environments
Authors: Cardona Vargas Arley , Arrieta Carlos E. , Tumay Hernando Alexander Yepes , Echeverri-Uribe Camilo , Amell Andrés 
Published: July 2021

The global energy demand enhances the environmental and operational benefits of natural gas as an energy alternative, due to its composition, mainly methane (CH4), it has low polluting emissions and benefits in energy and combustion systems. In the present work, the laminar burning velocity of methane was determined numerically and experimentally at two pressure conditions, 0.85 atm and 0.98 atm, corresponding to the city of Medellín and Caucasia, respectively, located in Colombia. The environmental conditions were 0.85 atm, 0.98 atm, and 295±1 K. The simulations and experimental measurements were carried out for different equivalence relations. Experimental laminar burning velocities were determined using the burner method and spontaneous chemiluminescence technique, flames were generated using burners with contoured rectangular ports to maintain laminar Reynolds numbers for the equivalence ratios under study and to reduce the effects of stretch and curvature in the direction of the burner's axis. In general, the laminar burning velocity fits well with the numerical results. With the results obtained, a correlation is proposed that relates the laminar burning velocity with the effects of pressure, in the form SL=aPb, where a and b are model constants. Sensitivity analysis was performed using the GRI-Mech 3.0 mechanism which showed that the most sensitive reaction was H+O2=O+OH (R38). Additionally, it was found that the reactions H+CH3 (+M)=CH4 (+M) (R52), 2CH3 (+M)=C2H6 (+M) (R158), and O+CH3=H+CH2O (R10) dominate the consumption of CH3 which is an important radical in the oxidation of methane, this analysis is carried out for equivalence ratios of 0.8 and 1.0, and atmospheric pressures of 0.85 atm and 0.98 atm
Implementation of marble waste as aggregate material rigid pavement
Authors: Aditya Candra , Irawan Dafid , Silviana Silviana 
Published: July 2021

The rigid pavement is used for the pavement with soft ground conditions (subgrade). On the other hand, in recent years, marble waste for civil construction has been widely used to substitute conventional materials such as fine and coarse aggregate in concrete. This study aims to optimize marble sand waste as a substitute for river sand aggregates on concrete pavements. This research creates innovation in the production of rigid pavement. The study used an experimental method to test the raw material, namely fine aggregate (river sand and marble sand) and rigid pavement testing, with various variations in the material's composition, including loading, strain, and concrete slab stress tests. The use of marble sand as a substitute for river sand affects the compressive strength of concrete. The maximum compressive strength of 34.67 N/mm² occurs at 60 % marble sand content. Calculation of the optimum level of marble sand by the regression method yielded 48.90 % with an average compressive strength of 32.37 N/mm². In terms of strain, rigid pavement concrete slabs with 60 % marble sand content showed the best performance among all specimens. The stretch is relatively small so that it is not so fluctuating, the flexibility is relatively small, and the stiffness is the highest. The strain character tends to be compressive so that the dependence on reinforcement will decrease. Dynamically at the shock load, the three concrete slabs are quite good and very far from resonance in both the traffic service load frequency and the large shock load. Rigid pavement concrete slabs with a marble sand content of 40 % show the best performance because they are damping faster and have less tension. Statically, rigid pavement concrete slabs with a marble sand content of 60 % are the best
Development of surface roughness model in turning process of 3X13 steel using TiAlN coated carbide insert
Authors: Nguyen Nhu-Tung , Trung Do Duc 
Published: July 2021

Surface roughness that is one of the most important parameters is used to evaluate the quality of a machining process. Improving the accuracy of the surface roughness model will contribute to ensure an accurate assessment of the machining quality. This study aims to improve the accuracy of the surface roughness model in a machnining process. In this study, Johnson and Box-Cox transformations were successfully applied to improve the accuracy of surface roughness model when turning 3X13 steel using TiAlN insert. Four input parameters that were used in experimental process were cutting velocity, feed rate, depth of cut, and insert-nose radius. The experimental matrix was designed using Central Composite Design (CCD) with 29 experiments. By analyzing the experimental data, the influence of input parameters on surface roughness was investigated. A quadratic model was built to explain the relationship of surface roughness and the input parameters. Box-Cox and Johnson transformations were applied to develop two new models of surface roughness. The accuracy of three surface roughness models showed that the surface roughness model using Johnson transformation had the highest accuracy. The second one model of surface roughness is the model using Box-Cox transformation. And surface roughness model without transformation had the smallest accuracy. Using the Johnson transformation, the determination coefficient of surface roughness model increased from 80.43 % to 84.09 %, and mean absolute error reduced from 19.94 % to 16.64 %. Johnson and Box-Cox transformations could be applied to improve the acuaracy of the surface roughness prediction in turning process of 3X13 steel and can be extended with other materials and other machining processes