bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Complex Interaction Between the Major Sleep Symptoms, the Severity of Obstructive Sleep Apnea, and Sleep Quality
Authors: Frangopoulos Frangiskos , Zannetos Savvas , Nicolaou Ivi , Economou Nicholas-Tiberio , Adamide Tonia , Georgiou Andreas , Nikolaidis Pantelis T. , Rosemann Thomas , Knechtle Beat , Trakada Georgia 
Published: February 2021

Introduction: Little information exists in the general population whether clinical presentation phenotypes of obstructive sleep apnea (OSA) differ in terms of sleep quality and comorbidities.Aim: The purpose of our study was to assess possible differences between symptomatic and asymptomatic OSA patients concerning syndrome's severity, patients' sleep quality, and comorbidities.Subjects and methods: First, in a nationwide, stratified, epidemiological survey, 4,118 Cypriot adult participants were interviewed about sleep habits and complaints. In the second stage of the survey, 264 randomly selected adults underwent a type III sleep study for possible OSA. Additionally, they completed the Greek version of Pittsburgh Sleep Quality Index (Gr-PSQI), Epworth Sleepiness Scale (ESS), Athens Insomnia Scale (AIS), and Hospital Anxiety and Depression Scale (HADS).Results: From 264 enrolled participants, 155 individuals (40 females and 115 males) were first diagnosed with OSA. Among these 155 patients, 34% had ESS ≥ 10 and 49% AIS ≥ 6. One or both symptoms present categorized the individual as symptomatic (60%) and neither major symptom as asymptomatic (40%). There were no significant statistical differences (SSDs) between the two groups (symptomatic–asymptomatic) with regard to anthropometrics [age or gender; neck, abdomen, and hip circumferences; and body mass index (BMI)]. The two groups had no differences in OSA severity—as expressed by apnea–hypopnea index (AHI), oxygen desaturation index (ODI), and mean oxyhemoglobin saturation (SaO2)—and in cardiometabolic comorbidities. Symptomatic patients expressed anxiety and depression more often than asymptomatics (p &lt; 0.001) and had poorer subjective sleep quality (Gr-PSQI, p &lt; 0.001). According to PSQI questionnaire, there were no SSDs regarding hours in bed and the use of sleep medications, but there were significant differences in the subjective perception of sleep quality (p &lt; 0.001), sleep efficiency (p &lt; 0.001), duration of sleep (p = 0.001), sleep latency (p = 0.007), daytime dysfunction (p &lt; 0.001), and finally sleep disturbances (p &lt; 0.001).Conclusion: According to our data, OSA patients reporting insomnia-like symptoms and/or sleepiness do not represent a more severe phenotype, by the classic definition of OSA, but their subjective sleep quality is compromised, causing a vicious cycle of anxiety or depression.
Monitoring of Adverse Drug Reaction-Related Parameters in Children and Adolescents Treated With Antipsychotic Drugs in Psychiatric Outpatient Clinics
Authors: Minjon Lenneke , Brozina Ivona , Egberts Toine C. G. , Heerdink Eibert R. , van den Ban Els 
Published: February 2021

Aim: To assess the frequency of monitoring of adverse drug reaction (ADR) related parameters in children and adolescents treated with antipsychotic drugs in psychiatric outpatient clinics and the considerations when monitoring was not performed.Methods: This retrospective follow-up study included 100 randomly selected outpatients aged ≤18 years who had a first prescription of an antipsychotic drug recorded in the electronic medical records of psychiatric outpatient clinics between 2014 and 2017. They were followed for up to 3 years. This study assessed the frequency of monitoring for physical parameters (weight, height, body mass index, waist circumference, pulse, blood pressure, and an electrocardiogram) and laboratory parameters (glucose, lipids, and prolactin) before the first prescription of an antipsychotic drug as well as during its use. Monitoring frequencies were stratified by the patient characteristics (sex, age, cardiovascular risk factors, and use of other psychotropic drugs), and by location of antipsychotic drug initiation (psychiatric outpatient clinic or elsewhere). Additionally, this study assessed the considerations mentioned in the medical records for not monitoring ADR-related parameters.Results: Overall, physical parameters were monitored more frequently (weight: 85.9% during the first half-year) than laboratory parameters (glucose and cholesterol: both 23.5%). There were no significant differences in monitoring at least one physical as well as in monitoring at least one laboratory parameter during the baseline period and during the total follow-up of antipsychotic drug treatment between the patient characteristics. In total, 3% of the children and adolescents were never monitored for any physical parameter, and 54% were never monitored for any laboratory parameter. For a minority of the children (14.8%) who were never monitored for laboratory parameters, considerations were recorded in their medical records, including refusal by the child or parents and monitoring performed by the general practitioner or elsewhere.Conclusion: Monitoring frequencies of ADR-related parameters in children and adolescents treated with antipsychotic drugs in psychiatric outpatient clinics varied and especially monitoring of laboratory parameters was infrequent. Considerations why monitoring was not performed were rarely recorded. The optimal method of monitoring and documentation thereof should become clear to optimize the benefit-risk balance of antipsychotic drug treatment for each child.
Emergence of NDM-5 Producing Carbapenem-Resistant Klebsiella aerogenes in a Pediatric Hospital in Shanghai, China
Authors: Pan Fen , Xu Qi , Zhang Hong 
Published: February 2021

Background: Carbapenem-resistant Klebsiella aerogenes (CRKA) has posed a serious threat for clinical anti-infective therapy. However, the molecular characteristics of CRKA in Shanghai are rarely reported.Objective: This study aimed to investigate the resistance profiles, dissemination mechanism, and molecular characteristics of CRKA strains isolated from children in a pediatric hospital, Shanghai.Method: Fifty CRKA isolates were collected in 2019. Antimicrobial susceptibility of the strains was determined by broth microdilution method. The β-lactamases and outer membrane porin genes were characterized by polymerase chain reaction (PCR). Conjugation experiments were performed to determine the transferability of the plasmids. The plasmids were typed based on their incompatibility group using the PCR-based replicon typing method. Multilocus sequence typing (MLST) and enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR) were performed for the genetic relationship.Results: All CRKA strains showed high level of resistance to cephalosporins and carbapenems, but still susceptible to aminoglycosides, colistin, and tigecycline. Forty five of fifty isolates carried blaNDM−5 genes (45/50, 90%), alongside with other β-Lactamase genes including blaCTX−M−1, blaTEM−1, and blaSHV−11 being detected. Loss of ompK35 and ompK36 genes were observed in 14% (7/50) and 28% (14/50), respectively, with 5 isolates lacking both ompK35 and ompK36. MLST analysis demonstrated that the majority of isolates belonged to ST4 (47/50, 94%) and ERIC-PCR fingerprinting was performed to identify NDM-5-producing isolates with approximately or more than 80% similarity levels. Plasmids carrying blaNDM−5 were successfully transferred to the E. coli recipient and plasmid typing showed that IncX3 were the prevalent among CRKA isolates.Conclusions: Our finding revealed the emergence of NDM-5 producing CRKA belonging to ST4 among children in Shanghai. Further attention should be paid to control the horizontal spread of the Class B carbapenemases like NDM in children.
A National Study of Colorectal Cancer Survivorship Disparities: A Latent Class Analysis Using SEER (Surveillance, Epidemiology, and End Results) Registries
Authors: Montiel Ishino Francisco A. , Odame Emmanuel A. , Villalobos Kevin , Liu Xiaohui , Salmeron Bonita , Mamudu Hadii , Williams Faustine 
Published: February 2021

Introduction: Long–standing disparities in colorectal cancer (CRC) outcomes and survival between Whites and Blacks have been observed. A person–centered approach using latent class analysis (LCA) is a novel methodology to assess and address CRC health disparities. LCA can overcome statistical challenges from subgroup analyses that would normally impede variable–centered analyses like regression. Aim was to identify risk profiles and differences in malignant CRC survivorship outcomes.Methods: We conducted an LCA on the Surveillance, Epidemiology, and End Results data from 1975 to 2016 for adults ≥18 (N = 525,245). Sociodemographics used were age, sex/gender, marital status, race, and ethnicity (Hispanic/Latinos) and stage at diagnosis. To select the best fitting model, we employed a comparative approach comparing sample-size adjusted BIC and entropy; which indicates a good separation of classes.Results: A four–class solution with an entropy of 0.72 was identified as: lowest survivorship, medium-low, medium-high, and highest survivorship. The lowest survivorship class (26% of sample) with a mean survival rate of 53 months had the highest conditional probabilities of being 76–85 years–old at diagnosis, female, widowed, and non-Hispanic White, with a high likelihood with localized staging. The highest survivorship class (53% of sample) with a mean survival rate of 92 months had the highest likelihood of being married, male with localized staging, and a high likelihood of being non-Hispanic White.Conclusion: The use of a person–centered measure with population-based cancer registries data can help better detect cancer risk subgroups that may otherwise be overlooked.
Benefits of GP care in outreach settings for people experiencing homelessness: a qualitative study
Authors: Hirst Victoria , Cuthill Fiona 
Published: February 2021

BackgroundAlthough people experiencing homelessness (PEH) have the worst health outcomes in society, they have a low uptake of primary care services. GP outreach has developed as a way of increasing their access into primary care but little is known about the experience of patients receiving care in this way.AimTo explore PEHs’ experiences of GP care in community outreach settings in UK; and to seek staff/volunteers’ views on the strengths and weaknesses of GP community outreach services.Design and settingA multi-method qualitative study with PEH and staff/volunteers working in three different community outreach settings in the UK.MethodIndividual semi-structured interviews were carried out with 22 PEH and two focus groups with key staff/volunteers. Data were analysed thematically using framework analysis.ResultsGP outreach services better enabled PEH to access medical care and staff/volunteers valued GP support to promote, and facilitate access to, healthcare services. In particular, the findings illuminate the high value that PEH placed on the organisational environment of the GP outreach service. Valued aspects of GP outreach were identified as comfortable, safe, and engendering a sense of belonging; convenient, opportunistic, and a one-stop shop; and being heard, having more time, and breaking down barriers.ConclusionThe organisational environment is important in enabling PEH to engage with GP services. The physical and organisational environment of the outreach settings were the most important factors; they created a space where professional barriers between the GP and patients were flattened, so facilitating a therapeutic relationship.
Remote primary care consultations for people living with dementia during the COVID-19 pandemic: experiences of people living with dementia and their carers
Authors: Tuijt Remco , Rait Greta , Frost Rachael , Wilcock Jane , Manthorpe Jill , Walters Kate 
Published: February 2021

BackgroundCOVID-19 has accelerated remote healthcare provision in primary care, with changes potentially permanent. The implementation of remote provision of health care needs to be informed by vulnerable populations, such as people living with dementia.AimTo understand the remote healthcare experiences of patients living with dementia and their family carers during the COVID-19 pandemic.Design and settingQualitative interviews with community-based patients living with dementia and their carers were carried out between May–August 2020, while the COVID-19 pandemic was ongoing in England.MethodSemi-structured interviews were conducted remotely by telephone or video call with 30 patients living with dementia and 31 carers. Data were analysed using thematic analysis.ResultsThree main themes were derived relating to: proactive care at the onset of COVID-19 restrictions; avoidance of healthcare settings and services; and difficulties with remote healthcare encounters. People living with dementia and their carers felt check-up calls were reassuring but limited in scope and content. Some avoided healthcare services, wishing to minimise COVID-19 risk or reduce NHS burden, or encountering technological barriers. Difficulties in remote consultations included lack of prompts to remember problems, dealing with new emerging difficulties, rescheduling/missed calls, and inclusion of the voice of the person with dementia.ConclusionWhile remote consultations could be effective, proactive calls could be more structured around needs. Consideration should be given to replace non-verbal prompts to describe problems, particularly for new health concerns. In continuing remote consultations, it is important to facilitate engagement with patients living with dementia and their carers to ensure good practice.
ROSEMARY VOLATILE OIL AS A PRESERVATIVE AGENT IN SOME CANNED MEAT FOODS
Authors: & et al. Abed 
Published: February 2021

This research was aimed to evaluate activity of Rosemary volatile oil and Nisin A in vivo and on B. cereus isolated from some canned meat products in vitro. The results showed that the activity of Rosemary volatile oil (2000 µg/ml) and Nisin A (350 µg\ml) attained to 27 and 19 mm inhibitory zone diameter respectively in well diffusion method. The viable plate count from samples of canned meat treated with effective concentration of Rosemary volatile oil and Nisin A were examined. The samples with Rosemary volatile oil was not showed any CFU/g after 9 days of preservation while sample with Nisin A and control observed 49 and 45 CFU/g respectively. In vivo experiment on mice, two weeks after oral dose of Rosemary volatile oil (2000 µg/ml) and Nisin A (350 IU\ ml), there were no death. Furthermore, there were no changes in histological sections taken from liver and spleen of mice treated with Rosemary volatile oil while Nisin A have shown changes in liver and spleen weights and gross or histological characteristics. In conclusion, the Rosemary volatile oil have higher antibacterial effect against B. cereus compare with using Nisin A which caused more damage to the organs in the liver and spleen, Thus, it can use the volatile oil of this plant as a preservative at the same time for preservation of meat.
Pengaruh Perencanaan Pajak dan Kualitas Laba Terhadap Nilai Perusahaan dengan Kinerja Keuangan Sebagai Variabel Intervening
Authors: Purnama Hari 
Published: February 2021

Penelitian ini bertujuan untuk menguji pengaruh Perencanaan Pajak , Kualitas Laba dan Kinerja keuangan terhadap Nilai Perusahaan. Untuk menguji pengaruh Perencanaan Pajak , dan Kualitas Laba terhadap kinerja keuangan. Untuk menguji pengaruh Perencanaan Pajak , dan Kualitas Laba terhadap Nilai Perusahaan yang dimoderasi kinerja keuangan.
Variabel penelitian ini terdiri dari variabel bebas dan terikat. Variabel bebas penelitian ini adalah Perencanaan Pajak, dan Kualitas laba, variabel terikatnya adalah Nilai Perusahaan dan variabel moderasi kinerja keuangan. Populasi dalam penelitian ini yaitu seluruh Perusahaan Food And Beverage yang berjumlah 19 perusahaan yang terdaftar di Bursa Efek Indonesia (BEI). Teknik Pengambilan Sampel purposive sampling, sehingga sampel yang masuk kriteria sebesar 13 perusahaan. Metode pengambilan data menggunakan dokumentasi. Teknik analisis yang digunakan adalah regresi linier berganda dengan taraf signifikansi 5%.
Perencanaan Pajak tidak berpengaruh terhadap Nilai Perusahaan. Sedangkan Kualitas Laba dan Kinerja keuangan secara parsial berpengaruh positif dan signifikan terhadap Nilai Perusahaan. Perencanaan Pajak tidak berpenagaruh terhadap kinerja keuangan. Kualitas laba secara parsial berpengaruh signifikan terhadap kinerja keuangan. Kinerja keuangan tidak mampu memediasi hubungan pengaruh Perencanaan Pajak terhadap Nilai Perusahaan. Kinerja keuangan mampu memediasi hubungan pengaruh Kualitas Laba terhadap Nilai Perusahaan.
PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN KONSUMEN PADA PERUSAHAAN MASTER PIECE KARAOKE DI KOTA BENGKULU
Authors: Abi Yudi Irawan 
Published: February 2021

The purpose of this study was to determine the effect of tangible, reliability, responsiveness, assurance and empathy of service quality to consumer satisfaction of Master Piece Karaoke in Bengkulu. The sampling technique in this study using purposive sampling techniques and data collection is done by distributing questionnaires to the respondents. The questionaires were distributed to the 100 respondent of Master Piece Karaoke in Bengkulu. The analysis tool used is multiple linear regression using SPSS 16. Hypothesis testing using the T test. Result shows that partially, tangible, reliability, responsiveness, assurance and empathy variables has significant effect on consumer satisfaction of Master Piece Karaoke in Bengkulu. Based on the analysis of known coefficient of determination value of Adjusted R Square is 0.477, this means 47,7% variable consumer satisfaction is influenced by variables service quality.
MANAJEMEN LABA YANG DIPENGARUHI OLEH MANAGERIAL OVERCONFIDENCE DAN KEPEMILIKAN KELUARGA
Authors: Yustisi Yuni Putri , Putri Destia Dwi 
Published: February 2021

ABSTRAK
Penelitian ini bertujuan untuk mengetahui tindakan manajemen laba yang dipengaruhi oleh managerial overconfidence dan kepemilikan keluarga. Penelitian ini menggunakan sebuah indeks untuk dapat mengukur variabel managerial overconfidence yang dikonstruksikan pada komponen aktivitas investasi, aktivitas pendanaan, dan kebijakan dividen dengan median industri sebagai pembanding. Data yang digunakan adalah sampel perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia selama tahun 2012-2017. Perusahaan manufaktur dipilih sebagai sampel penelitian dikarenakan perusahaan manufaktur memiliki tingkat volatility laba yang berubah-ubah. Metode penelitian yang digunakan dalam penelitian ini untuk menganalisis data dan menguji hipotesis adalah statistik deskriptif dan uji regresi linier berganda. Hasil pengujian statistik pada penelitian ini menunjukkan bahwa variabel managerial overconfidence berpengaruh positif terhadap manajemen laba. Selain itu, pengujian interaksi antara kepemilikan keluarga dengan managerial overconfidence tidak memperlemah terjadinya manajemen laba.
Kata Kunci: Managerial Overconfidence, Manajemen Laba, Kepemilikan Keluarga

ABSTRACT
This study aims to determine that earnings management is influenced by managerial overconfidence and family ownership. This study uses an indeks to measure the managerial overconfidence variable which is constructed in the components of investment activity, financial activity, and dividend policy with the industry median as a comparison. The data used is a sample of manufacturing companies listed on the Indonesian Stock Exchange during 2012-2017. Manufacturing companies are selected as research samples because manufacturing companies have varying levels of earnings volatility. This study's research method to analyze data and test hypotheses is descriptive statistics and multiple linear regression. The results of statistical tests in this study indicate that the managerial overconfidence variable has a positive effect on earnings management. In addition, testing the interaction between family ownership with managerial overconfidence does not equate to improved earnings management.
Keywords: Managerial Overconfidence, Earnings Management, Family Ownership
Minimal Conditions for Survival of Technological Civilizations in the Face of Stellar Evolution
Authors: Hansen Bradley M. S. , Zuckerman Ben 
Published: February 2021

Abstract
The ease of interstellar rocket travel is an issue with implications for the long-term fate of our own and other civilizations and for the much-debated number of technological civilizations in the Galaxy. We show that the physical barrier to interstellar travel can be greatly reduced if voyagers are patient, and wait for the close passage of another star. For a representative time of ∼1 Gyr, characteristic of the remaining time that Earth will remain habitable, one anticipates a passage of another star within ∼1500 au. This lowers the travel time for interstellar migration by ∼two orders of magnitude compared with calculated travel times based on distances comparable to average interstellar separations (i.e., ∼1 pc) in the solar vicinity. We consider the implications for how long-lived civilizations may respond to stellar evolution, including the case of stars in wide binaries, and the difficulties of identifying systems currently undergoing a relevant close encounter. Assuming that life originates only around G-type stars, but migrates primarily to lower mass hosts when the original system becomes uninhabitable, the fraction of extant technological civilizations that exist as diaspora can be comparable to the fraction that still orbit their original host stars.
Multiple Populations in Low-mass Globular Clusters: Palomar 13
Authors: Tang Baitian , Wang Yue , Huang Ruoyun , Li Chengyuan , Yu Jincheng , Geisler Doug , Dias Bruno , Fernández-Trincado José G. , Carballo-Bello Julio A. , Cabrera-Lavers Antonio 
Published: February 2021

Abstract
Since the discovery of chemically peculiar stars in globular clusters in the last century, the study of multiple populations has become increasingly important, given that chemical inhomogeneity is found in almost all globular clusters. Despite various proposed theories attempting to explain this phenomenon, fitting all the observational evidence in globular clusters with one single theory remains notoriously difficult and currently unsuccessful. In order to improve existing models and motivate new ones, we are observing globular clusters at critical conditions, e.g., metal-rich end, metal-poor end, and low mass end. In this paper, we present our first attempt to investigate multiple populations in low mass globular clusters. We obtained low-resolution spectra around 4000 Å of 30 members of the globular cluster Palomar 13 using OSIRIS/Multi-object spectrograph mounted at the Gran Telescopio Canarias. The membership of red giant branch stars is confirmed by the latest proper motions from Gaia DR2 and literature velocities. After comparing the measured CN and CH spectral indices with those of the stellar models, we found a clear sign of nitrogen variation among the red giant branch stars. Palomar 13 may be the lowest mass globular cluster showing multiple populations.