bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune checkpoint inhibitor-associated acute kidney injury and mortality: An observational study
Authors: Koks Marije S. , Ocak Gurbey , Suelmann Britt B. M. , Hulsbergen-Veelken Cornelia A. R. , Haitjema Saskia , Vianen Marieke E. , Verhaar Marianne C. , Kaasjager Karin A. H. , Khairoun Meriem 
Published: June 2021

Background
Immune checkpoint inhibitors, approved for the treatment of various types of cancer, are known to cause a unique spectrum of side effects, including acute kidney injury (AKI). The aim of this study was to describe the incidence, risk factors, renal outcomes, and mortality of AKI in patients receiving checkpoint inhibitors.

Methods
Patients receiving checkpoint inhibitors between January 2013 and May 2020 at the University Medical Center Utrecht, the Netherlands, were identified using the Utrecht Patient Oriented Database. AKI was defined as an increase in serum creatinine of ≥1.5 times the baseline value, based on the Kidney Disease: Improving Global Outcomes criteria. Cox proportional hazard regression analysis was used to assess risk factors for AKI and to evaluate the relationship between AKI and mortality. Persistent renal dysfunction was diagnosed in AKI patients with a final serum creatinine measurement of >1.3 times the baseline value.

Results
Among 676 patients receiving checkpoint inhibitors, the overall incidence of AKI was 14.2%. Baseline variables independently associated with AKI were a gynecologic malignancy, monotherapy with ipilimumab, and the use of a diuretic, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, or proton pump inhibitor at baseline. AKI was checkpoint inhibitor-associated in one third of all patients with AKI. Checkpoint inhibitor-associated AKI was mostly low-grade, occurred a median of 15 weeks after checkpoint inhibitor initiation, and resulted in persistent renal dysfunction in approximately 40% of the patients. Patients with all-cause AKI had a twofold increased mortality risk, but checkpoint inhibitor-associated AKI was not associated with increased mortality.

Conclusions
In this study, patients receiving checkpoint inhibitors frequently developed AKI due to various etiologies. AKI directly related to the effect of checkpoint inhibitor toxicity did not increase mortality. However, AKI not related to the effect of checkpoint inhibitor toxicity was associated with increased mortality.
Oncological principles in spinal tumor surgery
Authors: Zaborovskii N. S. , Ptashnikov D. A. , Mikhaylov D. A. , Smekalenkov O. A. , Masevnin S. V. 
Published: June 2021

Surgical intervention remains the cornerstone of the treatment of patients with spinal tumors. The presented literature review includes also the authors’ personal experience in the treatment of tumors. Pain relief, local control of a neoplasm growth and preservation of body functions are the main goals of this pathology treatment.Treatment of spinal tumors is based on the biology, location and extent of the neoplasm. If surgical treatment is indicated, en-bloc resection is the preferred method. This operation is based on the complete removal of the tumor in a single block entirely covered by a shell of healthy tissue. This surgical procedure can be challenging due to the proximity of the neural structures. Moreover, achieving clean resection margin around the tumor often requires the sacrifice of adjacent anatomic structures. A more comprehensive approach requires a combination of surgery, systemic therapy and radiotherapy to improve outcomes in patients with advanced spinal tumors.The fulfillment of oncological principles is fundamental to achieving best treatment outcomes for spinal tumors.
Six Weeks of Hip Joint Training Using a Novel Multihip Joint Board Improves Sprint Performance in Competitive Collegiate Male Sprinters
Authors: Nakata Hideomi , Nakanishi Yasuto , Otsuki Shingo , Mizuno Masuhiko , Connor Jonathan , Doma Kenji 
Published: June 2021

Abstract
Nakata, H, Nakanishi, Y, Otsuki, S, Mizuno, M, Connor, J, and Doma, K. Six weeks of hip joint training using a novel multihip joint board improves sprint performance in competitive collegiate male sprinters. J Strength Cond Res 36(10): 2891–2897, 2022—In a previous study, we identified the possibility that hip joint training using a multihip joint board (MHJB) may increase the cross-sectional area (CSA) of the psoas major (PM) muscle and improve sprint performance. However, the preliminary study reported descriptive findings because of a limited sample size. Therefore, we aimed to investigate and statistically infer the effects of the MHJB training protocol with a larger sample of male collegiate sprinters. The sprinters were randomly assigned to either the MHJB group (n = 7) or the control group (n = 7). The MHJB protocol consisted of 7 separate exercises targeting the development of the hip musculature, all using the MHJB device. The MHJB group undertook the MHJB protocol 3 times per week for 6 weeks, after their normal daily workout, whereas the control group completed their normal daily workout without the MHJB protocol. Sprint performance was recorded from official 100-m competitions before, and after, the 6-week training period. At the end of the training period, significantly greater improvement in PM CSA and 100-m sprint was noted in the MHJB group compared with the control group. These findings confirm the efficacy of MHJB training for increasing PM CSA and improve sprint performance in competitive male sprinters.
Effects of the COVID-19 Lockdown on Neuromuscular Performance and Body Composition in Elite Futsal Players
Authors: Spyrou Konstantinos , Alcaraz Pedro E. , Marín-Cascales Elena , Herrero-Carrasco Rubén , Cohen Daniel D. , Calleja-Gonzalez Julio , Pereira Lucas A. , Loturco Irineu , Freitas Tomás T. 
Published: June 2021

Abstract
Spyrou, K, Alcaraz, PE, Marín-Cascales, E, Herrero-Carrasco, R, Cohen, DD, Calleja-Gonzalez, J, Pereira, LA, Loturco, I, and Freitas, TT. Effects of the COVID-19 lockdown on neuromuscular performance and body composition in elite futsal players. J Strength Cond Res 35(8): 2309–2315, 2021—Recent world events (i.e., COVID-19 pandemic) led to an unparalleled situation in sports. Players were forced to stay at home for a prolonged period and not allowed to use their team's training facilities or even exercise outdoors. The main aim of this study was to examine the effects of the COVID-19 lockdown on neuromuscular performance and body composition in futsal players. Ten elite male players performed a 10-m sprint, horizontal and vertical jump, and body composition measurements before and after the quarantine (i.e., 70 days). Pre-post confinement differences in horizontal jump distance, countermovement jump variables, sprinting time, and body composition were analyzed by a paired sample t-test and effect sizes (ESs). A large and significant decline was observed in sprint ability (p = 0.004; ES = 1.31). Small and nonsignificant differences were found in horizontal jump performance (p = 0.243; ES = −0.39). Nonsignificant differences were observed in countermovement jump (CMJ) height (p = 0.076; ES = −0.63) but moderate-to-large significant declines were found in CMJ eccentric deceleration impulse, rate of force development, peak power, velocity, and landing peak force (p ≤ 0.05; ES = −0.52 – 1.23). Finally, trivial and nonsignificant differences were obtained on body composition parameters. In summary, sprint performance and specific CMJ kinetic variables were significantly affected by long-term reduced training, whereas vertical jump height and horizontal jump distance and body composition were not. Practitioners are advised to implement efficient sprint-oriented and eccentric-oriented training strategies to optimize return to competition after prolonged detraining periods.
Psychological and Physiological Changes in Response to the Cumulative Demands of a Women's Division I Collegiate Soccer Season
Authors: McFadden Bridget A. , Walker Alan J. , Bozzini Brittany N. , Hofacker Morgan , Russell Mark , Arent Shawn M. 
Published: June 2021

Abstract
McFadden, BA, Walker, AJ, Bozzini, BN, Hofacker, M, Russell, M, and Arent, SM. Psychological and physiological changes in response to the cumulative demands of a women's division I collegiate soccer season. J Strength Cond Res 36(5): 1373–1382, 2022—This study sought to determine the effects of a women's collegiate soccer season on psychological markers, biomarkers, sleep, and performance. Athletes participated in maximal countermovement vertical jump height (CMJ) assessments and biomarker monitoring in conjunction with subjective measures of psychological wellness and sleep questionnaires before preseason (S1) and every 4 weeks following (S2, S3, and S4). Training was monitored during practices and games using global positioning satellite systems and heart rate technology. Total training load was highest from S1 to S2, decreased from S2 to S3 (effect size [ES] = -2.5; p < 0.001), and remained stable from S3 to S4. CMJ declined at S2 (ES1-2 = −0.51; p = 0.001) and returned to baseline at S3. Increases from S1 to S2 were seen for creatine kinase (ES1-2 = 1.74), free testosterone (ES1-2 = 1.27), total testosterone (ES1-2 = 3.5), and free cortisol (ES1-2 = 0.88) (p < 0.03) before returning to baseline by S3 and S4 (free cortisol). Total cortisol was elevated throughout the season before declining at S4 (ES1-4 = −0.41; p = 0.03). Iron declined from S1 to S2 (ES1-2 = −0.73; p = 0.01) and returned to baseline values at S4, whereas growth hormone declined at S2 (ES1-2 = −0.50; p = 0.01) and remained depressed. Interleukin-6 increased at S4 (ES1-4 = 0.71; p = 0.02). Total training distress decreased from S1 to S2 (ES1-2 = −0.38; p = 0.02), returned to baseline by S3, and increased by S4 (ES1-4 = 0.57; p = 0.01). No changes were observed in markers of sleep (p > 0.05). Biomarkers showed notable changes after the highest workload period (S1-S2), which coincided with CMJ decrements. Biomarker perturbations preceded declines in subjective psychological wellness (S4) which occurred in the latter half of the season, indicating an accumulation of fatigue as the season progressed.
Short-animation video in web meeting classes for secondary school learners’ EFL writing achievement
Authors: Sari Dwi Nikita , Susilo Susilo , Limbong Efendi 
Published: June 2021

The study aims at investigating whether there is an effect of short animation video on the EFL narrative writing achievement of the secondary school EFL learners in the circumstance where web meeting was becoming the class. The study was an experimental study using Static Group Comparison Design. Respondents participated in the study were the 8th Graders of SMP Negeri 18 Samarinda, Indonesia. There were 32 students in the experimental group and the other 32 students in the control group. The data were collected by conducting writing tests, i.e. post-test for both the experimental and control groups. Independent sample t-test was used to test the significant difference for pre and post-test scores. The results revealed that the students under the experimental group (M = 83.22, SD = 7.979, N = 32) performed higher in scores on their narrative writing achievement than the students under the control group (M = 76.00, SD = 9.824, N = 32), t(32) = 3.227, p < .002, two-tailed. It means there is a significant difference between narrative writing achievement of the students under the experimental group and those under the control group. This finding implies there is a significant effect of short animation video on the narrative EFL writing achievement of the secondary school EFL learners.
A review of safety considerations for batteries in aircraft with electric propulsion
Authors: Sripad Shashank , Bills Alexander , Viswanathan Venkatasubramanian 
Published: June 2021

AbstractModern aircraft designs for “more electric” and “fully electric” aircraft have large battery packs ranging from tens of kWh for urban aviation to hundreds or thousands of kWh for commercial aviation. Such large battery packs require careful consideration of the safety concerns unique to aviation. The most pertinent safety concerns related to batteries can be categorized into two broad areas: exothermic heat related events (thermal issues) and partial or complete loss of safety–critical power supply (functional issues). Degradation during operation of a battery can contribute to capacity fade, increased internal resistance, power fade, and internal short circuits, which lead to the loss of or decrease in propulsive power. When batteries are the primary source of onboard power and energy, it is crucial to be able to estimate their state-of-health in terms of capacity and power capability. Internal short circuits and other sources of excessive heat generation can lead to high temperatures within the cells of a battery pack leading to safety concerns and thermal events. One of the biggest risk factors for batteries used in aviation is the potential for thermal runaway where temperatures reach the flashpoint of one of the cell components, eventually cascading over multiple cells leading to system-wide battery pack failure and a fire hazard. This article reviews the current understanding of the safety concerns related to batteries in the context of urban and regional electric aviation.
Perfil y características del emprendedor como aspectos determinantes en el progreso de ideas empresariales
Authors: Adie-Villafañe Jonathan , Cárdenas-Ortiz Luis-Carlos 
Published: June 2021

Objetivo: Este estudio caracterizó el perfil del emprendedor en los individuos participantes del programa de financiamiento al emprendedor Fondo Emprender, coordinado por el Servicio Nacional de Aprendizaje (SENA) entre los años 2014 y 2018, a fin de conocer los aspectos de la dinámica emprendedora en el departamento del Atlántico. Método: Para el desarrollo de la investigación se empleó un enfoque cuantitativo, con paradigma empírico analítico, diseño no experimental y de tipo descriptivo, estudiando una muestra de 100 individuos emprendedores. Resultados y Discusión: Del análisis del perfil emprendedor, fue posible apreciar una mayor participación del género femenino en la actividad emprendedora; rangos de edad entre los 10 y 34 años; nivel académico secundario, técnico y tecnólogo y, el sector empresarial servicios. Con respecto a las características del emprendedor, se observó una tendencia hacia el no cumplimiento en la capacidad de negociación, asunción de riesgos, innovación y creatividad, liderazgo de equipos, capacidad de trabajo, confianza en sí mismo y la flexibilidad y adaptarse a cambios. Conclusión: Es pertinente que, los programas de financiamiento al emprendedor como el Fondo Emprender, fomenten la necesidad de formación frecuente del emprendedor, en aras de educarse sobre maneras asertivas para establecer estrategias empresariales que garanticen su estabilidad organizacional.
El Presupuesto Participativo como mecanismo de participación ciudadana presente en los Estados de México
Authors: Rodríguez Burgos Karla , Guajardo Solís Marcela Cavazos 
Published: June 2021

El presente estudio tiene como objetivo identificar el respaldo legal en materia de Presupuesto Participativo aplicando un análisis de contenido comparado de los mecanismos y leyes de Participación Ciudadana con que cuentan los 32 Estados de México. Entre los resultados obtenidos se detectó que 29 de los 32 Estados de México cuentan con respaldo legal en el tema de participación ciudadana y solo 4 de éstos incluyen al Presupuesto Participativo como herramienta de participación, lo cual se presenta como un área de oportunidad para los Estados para involucrar más activamente a los ciudadanos, ya que esta herramienta es una forma exitosa a nivel mundial del involucramiento activo de los ciudadanos en las democracias participativas, permitiéndoles directamente la toma de decisiones, ejerciendo el presupuesto en donde consideren que es prioritario
Substantial Violation of Human Rights and Freedoms as a Prerequisite for Inadmissibility of Evidence
Authors: Yevhenovych Ablamskyi Serhii , Volodymyrivna Havryliuk Liudmyla , Georgievna Drozd Valentyna , Volodymyrivna Nenia Olena 
Published: June 2021

Objective: The aim of the article is to analyze the various legal and theoretical provisions related to the determination of legal content of the concept of finding evidence inadmissible due to substantial violation of human rights and freedoms. Method: The authors use general scientific and special methods that enable to obtain scientifically sound conclusions and proposals. In particular, scientific methods, such as dialectical, comparative-legal, system-structural, generalization and logical, are applied. Results: The problematic issues of the procedure for finding evidence inadmissible due to substantial violation of human rights and freedoms in the criminal proceedings of Ukraine are studied. Some essential violations in collecting evidence by the prosecution are under focus. The ECHR’s case-law with regard to procedure for finding evidence inadmissible is analyzed. The implementation of the doctrine of "fruit of the poisonous tree" and specificity of its application to direct and derivative evidence by domestic courts and the case law of the ECHR is considered. Conclusions: The authors argue that the investigator is required to comply with the procedure for investigative actions prescribed by the provisions of the CPC of Ukraine in order to ensure human rights and freedoms. The analysis of the application of provisions of the CPC of Ukraine and the ECHR’s case law regarding the issue raised enables to formulate sound conclusions.
Prosthodontic rehabilitation of residual mandibular defect with Fixed removable Hybrid prosthesis- A case report
Authors: Prakash Poonam , Gowda Mahesh , Sahoo NK 
Published: June 2021

Ameloblastoma is a rare, benign tumor of odontogenic epithelium that was recognized in 1827 by Cusack and renamed ameloblastoma in 1930 by Ivey and Churchill. Ameloblastomas can be found both in the maxilla and mandible with a greater predilection of about 80% in the mandible with the posterior ramus area being the most frequent site. While chemotherapy, radiation therapy, curettage and liquid nitrogen have been effective in some cases of ameloblastoma, surgical resection remains the most definitive treatment for this condition. Rehabilitation of residual mandibular defect post resection is a challenge due to long span compromised ridge condition and the absence of dentition. In such scenario, a fixed-removable prosthesis allows rapid return to excellent function by providing favorable biomechanical stress distribution along with restoration of esthetics, phonetics and ease of postoperative care and maintenance.This paper presents successful Prosthodontic rehabilitation of a patient with a large residual mandibular defect secondary to surgical resection for ameloblastoma using fixed-removable hybrid prosthesis.
SAÚDE DE HOMENS NA PANDEMIA DA COVID-19: PANORAMA BRASILEIRO
Authors: Sousa Anderson Reis , Araújo Isabella Félix Meira , Borges Cléa Conceição Leal , De Oliveira Josias Alves , De Almeida Márcio Soares , Caribé Wellington , Santos Junior Fernando Jorge Nascimento , Pereira Álvaro 
Published: June 2021

<p><strong>Objetivo: </strong>apresentar o panorama da saúde de homens em vivência da pandemia da Covid-19 no Brasil.<strong> Método: </strong>estudo qualitativo, realizado com<strong> </strong>100 homens residentes no Brasil. Aplicou-se um formulário online e os dados apreendidos foram analisados pelo Discurso do Sujeito Coletivo,<strong> </strong>sustentado na Teoria da Adaptação de Enfermagem. <strong>Resultados: </strong>a pandemia da Covid-19 mobilizou as dimensões de saúde física, afetiva e sexual, familiar e conjugal, saúde no e do trabalho, financeira, social, emocional, psicológica e mental, espiritual, religiosa e bioenergética dos homens. <strong> Conclusão: </strong>Repercussões deletérias, modos de adaptação para o enfrentamento e o cuidado de si dos homens compuseram o panorama da saúde no contexto pandêmico da Covid-19. <strong></strong></p>
DEMOGRAPHIC PREDICTION TOWARDS LEADERSHIP AND TEACHERS’ COMMITMENT AND MOTIVATION IN THE EDUCATIONAL SECTOR
Authors: Jabeen Afshan , Luqman Muhammad Safdar , Zia-ul-Islam Syed , Khan Muhammad Asghar , Manzoor Mehhwish 
Published: June 2021

Purpose of the study: The existing research study aimed to investigate the predictive effect of demographic traits, leadership styles on teachers’ job commitment and motivation at the college level, in Punjab, Pakistan.
Methodology: The population of the study consisted of 576 male and female lecturers (PE). The total number of lecturers (PE) working in all Government colleges is 576, male lecturer (PE) is 366, and female lecturers (PE) are 210. Three self cum closed-ended questionnaires were designed for the data collection. Mean, standard deviation, Independent Samples Test, and One-way ANOVA were applied to test the formulated hypotheses.
Main Findings: It was found that there no positive impact of leadership styles of the head of institutions upon professional commitment and motivation of the lecturers based on demographics. It was also found that the study respondents regarding demographic attributes have significant group mean differences in opinion about the research variables under study.
Implications of the study: It was recommended that the most motivated and committed worker is the one who is senior, married, educated, and female, has a sound salary package, has served the institution for a long time- period and has a chance of professional development. It was also found that s/he performs his/her duty under an HOI who has more of a transformational leadership style than the rest and should be more transformational. Therefore HOI of the institutions should adopt a transformational leadership style to get maximum output from the employees.
Detection of Escherichia coli in Postpartum Clinical Endometritis of Dairy Cattle by PCR
Authors: Kumar D.B. Chetan , Chacko Leeba , Promod K. , Sumod K. 
Published: June 2021

Background: Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Klebsiella pneumoniae (K. pneumoniae), Bacillus spp. and Fusobacterium necrophorum (F. necrophorum) are the common bacterial agents isolated from postpartum endometritis in dairy cattle. The objective of the present study was to determine the association of E. coli with postpartum endometritis by polymerase chain reaction (PCR). Methods: The present study was conducted from September 2019 to January 2020 at Teaching Veterinary Clinical Complex, College of Veterinary and Animal Sciences, Pookode, Kerala and organised dairy farms in Wayanad district, Kerala. Endometrial cytobrush samples (n = 36) were collected by cytobrush technique at 28 to 35 days postpartum (dpp). 16S rRNA gene was employed for the identification of E. coli by PCR. Result: Upon evaluating endometrial cytological smear, 26 animals were positive for endometritis with more than 5% polymorphonuclear (PMN) cells. The prevalence of endometritis was 72.22 per cent (26/36). E. coli was detected in 12 samples by PCR. The study suggested PCR as a highly sensitive method for the identification of E. coli associated with endometritis in postpartum dairy cows.