bluuebunny/crossref_metadata_2025_split huggingface dataset:
A continuous performance management approach: Effects of daily performance management behaviors on leader‐member exchange, next‐day job attitudes, and job performance
Authors: Zhang Xiyang , Qian Jing 
Published: February 2025

AbstractBuilding on the trend of performance management (PM) moving towards more frequent and the research gap for the effectiveness of the modern form of PM, we adopt an experience sampling method to study daily PM behaviors continuously for two weeks. Our theoretical model was tested using 906 observations from 97 full‐time employees, providing initial evidence for daily PM's effectiveness in increasing employee next‐day job attitudes and job performance. Moreover, we also revealed the relationship‐based mechanism underlying the effects of daily PM. Specifically, our findings suggest that daily PM behaviors increase employee next‐day job satisfaction, job engagement, and job performance because PM behaviors make employees perceive a higher leader‐member exchange relationship. Importantly, we found the boundary conditions for PM behaviors in increasing this exchange relationship quality. The relationship was weaker when work stressors (i.e., workload and cognitive stressors) were high rather than low. We discuss theoretical and practical implications, limitations, and future research directions.
Revisiting the relationship between career plateau and job performance: A social‐cognitive perspective
Authors: Yang Wei‐Ning , Wang Yu‐Hsuan , Doden Wiebke , Wang Pei‐Yun 
Published: February 2025

AbstractPrevious studies examining the influence of career plateau on job performance have primarily adopted a social exchange or conservation‐of‐resources perspective, but support for these perspectives has been inconsistent. Our research takes a novel theoretical approach by investigating how and when career plateau affects job performance through a social‐cognitive lens. Specifically, we propose job self‐efficacy as a mechanism through which hierarchical and job content plateau affect job performance, and that these relationships will be moderated by career stage. Path analysis results from a multi‐wave, multisource study featuring supervisor–subordinate dyads indicate that a hierarchical plateau (where promotions are perceived as unlikely) is associated with lower job self‐efficacy and, in turn, lower supervisor‐rated performance for employees in the maintenance career stage. In contrast, a job content plateau (where employees perceive a lack of new responsibilities and work challenges) is associated with higher job self‐efficacy and, in turn, better supervisor‐rated performance, regardless of their career stages. By applying a novel theoretical perspective, we enhance understanding of the relationship between career plateau and employee performance.
Effects of Pretreatment With Coenzyme Q10 (CoQ10) and High‐Intensity Interval Training (HIIT) on FNDC5, Irisin, and BDNF Levels, and Amyloid‐Beta (Aβ) Plaque Formation in the Hippocampus of Aβ‐Induced Alzheimer's Disease Rats
Authors: Puoyan‐Majd Samira , Parnow Abdolhossein , Rashno Masome , Heidarimoghadam Rashid , komaki Alireza 
Published: February 2025

ABSTRACTAimsPhysical exercise has been shown to protect against cognitive decline in Alzheimer's disease (AD), likely through the upregulation of brain‐derived neurotrophic factor (BDNF). Recent studies have reported that exercise activates the FNDC5/irisin pathway in the hippocampus of mice, triggering a neuroprotective gene program that includes BDNF. This study aimed to investigate the effects of 8 weeks of pretreatment with coenzyme Q10 (CoQ10) and high‐intensity interval training (HIIT), both individually and in combination, on FNDC5, irisin, BDNF, and amyloid‐beta (Aβ) plaque formation in the hippocampus of Aβ‐related AD rats.MethodsIn this study, 72 male Wistar rats were randomly assigned to one of the following groups: control, sham, HIIT (low intensity: 3 min running at 50%–60% VO2max; high intensity: 4 min running at 85%–90% VO2max), Q10 (50 mg/kg, orally administered), Q10 + HIIT, AD, AD + HIIT, AD + Q10, and AD + Q10 + HIIT.ResultsAβ injection resulted in a trend toward decreased levels of FNDC5, irisin, and BDNF, alongside increased Aβ plaque formation in the hippocampus of Aβ‐induced AD rats. However, pretreatment with CoQ10, HIIT, or their combination significantly restored hippocampal levels of FNDC5, irisin, and BDNF, while also inhibiting Aβ plaque accumulation in these rats.ConclusionPretreatment with CoQ10 and HIIT improved the Aβ‐induced reduction in BDNF levels probably through the FNDC5/irisin pathway and preventing Aβ plaque formation.
NFAT1 Signaling Contributes to Bone Cancer Pain by Regulating IL‐18 Expression in Spinal Microglia
Authors: Chen Xuetai , Zeng Ying , Wang Zizhu , Zhu Jixiang , Liu Fengyun , Zhu Mingxuan , Zheng Jiayi , Chen Qingdaiyao , Zhai Dongxu , Chen Yangyang , Niu Jiayao , Xue Zhouya , Sun Guan , Li Feng , Pan Zhiqiang 
Published: February 2025

ABSTRACTAimsThis study aimed to test the hypothesis that nuclear factor of activated T cells 1 (NFAT1) signaling contributes to bone cancer pain by regulating interleukin (IL)‐18 expression in spinal microglia.MethodsThis study was performed on male mice using a Lewis lung carcinoma‐induced bone cancer pain model. Nociceptive behaviors were evaluated by measuring mechanical allodynia, thermal hyperalgesia, and spontaneous pain. Expression levels were measured via real‐time quantitative polymerase chain reaction, western blotting, and immunofluorescence analysis. The effect of pharmacologic intervention of spinal NFAT1/IL‐18 signaling on bone cancer pain was the primary outcome.ResultsNFAT1 expression was upregulated in the spinal microglia after tumor inoculation. Pharmacological inhibition of NFAT1 upregulation prevented and reversed bone cancer‐related pain behaviors. In spinal microglia, NFAT1 inhibition decreased p38 MAPK phosphorylation and IL‐18 production. Blocking NFAT1 signaling suppressed tumor‐induced neuronal sensitization and microglial activation as well as activation of the N‐methyl‐D‐aspartate receptor and the subsequent Ca2+‐dependent signaling.ConclusionMicroglia NFAT1‐p38 signaling contributes to bone cancer pain through IL‐18‐mediated central sensitization in spinal microglia. NFAT1 could be a potential target for therapeutic intervention to prevent bone cancer pain.
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF‐1α Signaling Pathway
Authors: Zhou Jiabin , Lei Yu , Zhang Shilin , Liu Yuhan , Yi Dongye 
Published: February 2025

ABSTRACTBackgroundCerebral ischemic stroke (CIS) is a debilitating neurological condition lacking specific treatments. Cerebral ischemia/reperfusion injury (CIRI) is a critical pathological process in CIS.PurposeThis study aimed to explore the protective effects of panaxadiol (PD) against oxidative stress‐induced neuronal apoptosis in CIS/CIRI and its underlying mechanisms.MethodAn MCAO mouse model was established to investigate the therapeutic effects of PD in vivo. Network pharmacology and molecular docking techniques were used to predict PD's anti‐CIS targets. The protective effects of PD were further validated in vitro using oxygen–glucose deprivation/reoxygenation (OGD/R)‐treated HT22 cells. Finally, core targets were verified through combined in vivo and in vitro experiments to elucidate the mechanisms of PD in treating CIS.ResultPD exhibited significant neuroprotective activity, demonstrated by restoration of behavioral performance, reduced infarct volume, and decreased neuronal apoptosis in mice. Network pharmacology analysis identified 24 overlapping target genes between PD and CIS‐related targets. The hub genes, PTGS2, SERPINE1, ICAM‐1, STAT3, MMP3, HMOX1, and NOS3, were associated with the HIF‐1α pathway, which may play a crucial role in PD's anti‐CIS effects. Molecular docking confirmed the stable binding of PD to these hub genes. Both in vitro and in vivo experiments further confirmed that PD significantly mitigates neuronal apoptosis and oxidative stress induced by CIS/CIRI.ConclusionPD significantly counteracts CIS/CIRI by modulating the JAK3/STAT3/HIF‐1α signaling pathway, making it a promising therapeutic agent for treating CIS/CIRI.
Treatment‐Free Remission Outcomes in a BCR::ABL1 Digital PCR Selected Clinical Cohort of CML Patients
Authors: Kockerols C. , Valk P. J. M. , Hogenbirk P. , Geelen I. , Blijlevens N. M. A. , Janssen J. J. W. M. , Hoogendoorn M. , Kersting S. , Klein S. K. , Daenen L. G. M. , Donker M. , te Boekhorst P. A. W. , Jie K.‐S. G. , Corsten M. , Cruijsen M. J. , Levenga H. , Smit W. M. , Levin M.‐D. , de Jongh E. , de Jonge S. , Vlot A. J. , Durian M. F. , Zwaginga J. J. , Mohlmann M. , Wustman T. J. , Blommers R. , Cornelissen J. J. , Westerweel P. E. ,   Collaborating Authors
Published: February 2025

ABSTRACTApproximately 40%–60% of patients reaching a stable deep molecular response during TKI treatment will maintain a state of remission after TKI discontinuation, denoted as treatment‐free remission (TFR). Depth of molecular response assessed by BCR::ABL1 digital PCR prior to TKI discontinuation has demonstrated its significance as a reliable predictive parameter for TFR. A clinically applicable prediction cutoff of 0.0023%IS has been established and externally validated. In this study, BCR::ABL1 digital PCR, as most sensitive and stable assay of its kind, was investigated as a TFR prediction tool in the Netherlands, and evaluated for its predictive value to stop TKI treatment below the aforementioned cutoff. The primary endpoint of molecular recurrence (MolR, BCR::ABL1 > 0.1%IS) at 12 months was prospectively assessed. Overall, 67 discontinued patients below the set BCR::ABL1 digital PCR cutoff were included. The overall MolR probability was 50% (95% CI, 36%–62%). In 38 patients treated for more than 6 years as commonly recommended as desirable treatment duration before TFR attempt, the MolR probability dropped to 36% (95% CI, 18%–50%). Patients attempting an early TKI discontinuation (treated for less than 6 years) had a high MolR probability of 76% (95% CI, 65%–89%). BCR::ABL1 digital PCR was successfully used in Dutch clinical practice. Our study indicates that in patients with a low BCR::ABL1 digital PCR result, a total TKI treatment duration of six or more years remains associated with a lower MolR rate and should generally be pursued. In patients treated for more than 6 years, BCR::ABL1 digital PCR was capable to identify stop candidates with a higher probability of TFR success.
Conflict and Father Involvement: The Unique Role of Postpartum Destructiveness for Fathers' Direct Care in Toddlerhood
Authors: Murray‐Perdue Samantha A. , Rayburn Stephanie , Wang Lijuan , Cummings E. Mark , Braungart‐Rieker Julia M. 
Published: February 2025

ABSTRACTFather involvement in childcare is associated with positive outcomes for children. Growing evidence supports many predictors of fathers' involvement, including maternal gatekeeping and father characteristics. The present study focuses on fathers' postpartum experiences, exploring parallel insights from environmental, interpersonal, and internal factors after having a baby to predict later involvement. We investigated how early household chaos, couple conflict, and father depressive symptoms in infancy predict later direct involvement in toddler care. The current study utilized data from 202 families participating in a parenting intervention program. We longitudinally assessed father reports of household chaos and their depressive symptoms, and employed an observational measure of conflict, at 6, 12, and 18 months postpartum to predict mother and father reports of father direct contributions to childcare at 18 months. Latent variables were created for household chaos, depressive symptoms, and destructiveness to incorporate reports 6 months apart. A structural equation model indicated father appraisals of household chaos were positively associated with depressive symptoms over time. Furthermore, couple destructiveness was negatively predictive of mothers' reports, but not fathers' reports of father direct care at 18 months after controlling for direct care behavior within 6 months postpartum. These results suggest that although father appraisals of his environment likely relate to his mental health, couple functioning played a greater role over time in direct care. We emphasize including fathers' appraisals of their experience in future research and underscore the potential impact of intervening at the couple level postpartum to support fathers' direct involvement in childcare over time.
Climate‐Influenced Ecological Memory Modulates Microbial Responses to Soil Moisture
Authors: Liang Shuxin , Zhu Wenjin , Zhang Weihong , Geng Jun , Grossart Hans‐Peter , Fang Linchuan , Shi Yu , Yang Yuyi 
Published: February 2025

ABSTRACTLong‐term climatic differences shape the ecological memory of soil bacterial communities, which refers to the ability of past events to influence current environmental responses. However, their ecological mechanisms and consequences for bacterial responses to current environmental changes remain largely unknown, particularly in terms of temporal dynamics. Therefore, soil bacterial communities in the arid (Lhasa River Basin) and humid (Nyang River Basin) grasslands of the Qinghai‐Tibet Plateau were compared to explore their temporal dynamics in response to current soil moisture and the resulting ecological consequences. Our results indicate that the differences between current and historical soil moisture determine the degree of divergence in bacterial community composition and potential function. The temporal dynamics of bacterial community composition, life strategies, and potential functions differed with environmental history, even under comparable moisture conditions. In contrast, bacterial communities with the same environmental history exhibited similar temporal dynamics, suggesting that environmental history has an important influence on bacterial community dynamics. This phenomenon may be caused by the continuous accumulation of bacterial community life strategies as an informational legacy, regulating future response patterns to soil moisture changes and thereby affecting biogeochemical cycles in the soil. For example, soil bacterial communities in relatively arid regions may increase their potential for dormancy, even when the current soil environment is moist, thereby enhancing ecosystem resilience by improving their capacity to respond to future drought events. This study provides new insights into the ecological memory of soil bacteria, emphasizing its critical role in influencing the compositional and functional changes of bacterial communities in response to current environmental changes. It highlights the significance of understanding the effect of environmental history in predicting the future responses of bacterial communities to disturbances and environmental changes.
The Depletion of TRAIP Results in the Retention of PCNA on Chromatin During Mitosis Leads to Inhibiting DNA Replication Initiation
Authors: Shiomi Yasushi , Hayashi Akiyo , Saito Yuichiro , Kanemaki Masato T. , Nishitani Hideo 
Published: February 2025

ABSTRACTLoading PCNA onto chromatin is a pivotal step in DNA replication, cell cycle progression, and genome integrity. Conversely, unloading PCNA from chromatin is equally crucial for maintaining genome stability. Cells deficient in the PCNA unloader ATAD5‐RFC exhibit elevated levels of chromatin‐bound PCNA during S phase, but still show dissociation of PCNA from chromatin in mitosis. In this study, we found that depletion of TRAIP, an E3 ubiquitin ligase, results in the retention of PCNA on chromatin during mitosis. Although TRAIP‐depleted cells with chromatin‐bound PCNA during mitosis progressed into the subsequent G1 phase, they displayed reduced levels of Cdt1, a key replication licensing factor, and impaired S phase entry. In addition, TRAIP‐depleted cells exhibited delayed S phase progression. These results suggest that TRAIP functions independently of ATAD5‐RFC in removing PCNA from chromatin. Furthermore, TRAIP appears to be essential for precise pre‐replication complexes (pre‐RCs) formation necessary for faithful initiation of DNA replication and S phase progression.
Public Stigma of Stroke Scale: Turkish Validity and Reliability Study
Authors: Turan Gülcan Bahcecioglu , Özer Zülfinaz , Yıldız Esra 
Published: February 2025

ABSTRACTObjectiveThis study was conducted to examine the validity and reliability of the Turkish version of the Public Stigma of Stroke Scale (PSSS).BackgroundThe stigma perceived by patients who have had stroke affects the quality of life as well as many health‐related factors. Therefore, it is necessary to determine the society's stigmatization of the stroke patient and to reveal the differences related to stroke in different cultures.DesignThis study is methodological research.MethodsThis study was conducted with 410 individuals aged 18 and over. The data were collected by using descriptive information form and PSSS. The data were evaluated by using exploratory and confirmatory factor analysis, Cronbach's alpha, McDonald's Omega reliability, composite reliability, mean variance extracted and test–retest analysis.ResultsFactor load values of the scale items were found to vary between 0.585 and 0.904. The fit index values in the scale were found as X2/df = 2.42, < 0.001, CFI = 0.934, TLI = 0.928, SRMR = 0.042 and RMSEA = 0.059. It was found that Cronbach's alpha coefficients of the factors of the scale ranged between 0.916 and 0.946, and the total Cronbach's alpha coefficient was 0.897. Total McDonald's omega coefficient was found to be 0.897, and McDonald's omega coefficients of the factors were found to be between 0.921 and 0.951. Total composite reliability was found to be 0.981, and total mean variance extracted was found to be 0.740. It was found that the Turkish version of the 33‐item and four‐factor scales was confirmed without any changes in the original scale form.ConclusionTurkish version of PSSS is a valid and reliable measurement tool for the evaluation of the stigmatization of stroke patients by the public and for use in clinical practice.
Self‐reactive B cells are increased in all major stages of peripheral development in Sjögren's disease
Authors: Lee Adrian YS , Qi Zhankun , Jackson Katherine JL , Reed Joanne H 
Published: February 2025

AbstractSjögren's disease (SjD) is a chronic autoimmune disorder characterized by increased circulating self‐reactive B cells. While many of these self‐reactive B cells emerge from the bone marrow, it is not known whether they are excluded from or enriched in specific developmental stages in the periphery. The aim of this study was to determine the immunophenotype of circulating self‐reactive B cells in SjD to inform more precise therapeutic targeting. Five major B cell populations: transitional, mature naïve, switched memory, double negative and plasmablasts were single‐cell sorted and cultured to produce IgG. Self‐reactive IgG was identified by ELISA, flow cytometry of permeabilized HEK293 cells and HEp‐2 indirect immunofluorescence. Immunoglobulin heavy chains were sequenced by Sanger and next‐generation sequencing. Compared with healthy donor controls (HCs), SjD patients had higher frequencies of naïve and CD21low atypical memory B cell subsets, while antigen‐experienced B cells expressed more Ki67 and CD86. B cells recognizing intracellular self‐antigens were identified in all stages of peripheral B cell development for SjD and HCs, but frequencies of autoreactive B cells were up to 10‐fold higher in SjD. Self‐reactive transitional B cells expressed higher surface CD38 and lower surface IgM. An increase in self‐reactive B cells throughout peripheral development in SjD compared with HCs suggests that counterselection of autoantibody‐bearing B cells during central and peripheral tolerance checkpoints are reduced in SjD. Therapeutic strategies focused on depleting B cells based on B cell receptor specificity rather than the developmental stage would be more efficient to target self‐reactive B cells in SjD.
Factors Influencing Contact Force in Robotic Magnetic Navigation Ablation
Authors: Orczykowski Michal , Bak Maciej , Kaczmarek Krzysztof , Urbanek Piotr , Robert Bodalski , Dubowski Krzysztof , Warminski Grzegorz , Derejko Pawel , Ptaszynski Pawel , Sterlinski Maciej , Bilinska Maria , Szumowski Lukasz 
Published: February 2025

ABSTRACTIntroductionStability of catheter‐tissue contact in the robotic magnetic navigation (RMN) system is one of the key features that distinguishes this system from manually guided catheters. Numerous studies have shown that contact force (CF) in manually controlled catheters is as crucial for forming an optimal lesion as the duration of application or power. Catheters used in the RMN system lack a quantitative method for intraoperative monitoring of this parameter. Our study aims to partially address this gap in scientific knowledge.MethodsWe conducted a total of 1200 CF measurements using the RMN system (Stereotaxis, St. Louis, MO, USA), a magnetic‐guided 8 Fr RF ablation catheter (THERMOCOOL RMT Catheter, Biosense Webster, Irvine, CA, USA) inserted through a long sheath (SR0, Abbott Cardiovascular, Nathan Lane North, Plymouth, MN, USA), and a precision jewelry scale (IKEME, Guangdong, CN). We analyzed the impact on the obtained CF values of four different magnetic field vectors (transverse, sagittal, caudal, and cranial), two field strengths (0.1T and 0.08T), and three catheter extension configurations from the long sheath (with Position 1 being the least extended and Position 3 the most extended).ResultsThe contact force values varied significantly across the different magnetic field vectors, field strengths, and catheter extensions from the vascular sheath.The greatest differences in achieved values were observed across the different magnetic field vectors in the Position 1, ranging from 3.52 ± 0.1 g (caudal plane) to 15.15 ± 0.05 g (cranial plane) at 0.08 Tesla (T) field strength (p < 0.001), and from 4.10 ± 0.06 g (caudal) to 15.01 ± 0.07 g (cranial) at 0.1 T, p < 0.001. Differences in other vectors reached approximately 20%.The highest CF values were obtained in Position 1, intermediate values in Position 2, and the lowest in Position 3. An exception was the transverse vector, where, particularly with a magnetic field of 0.1 T, more similar values were observed across Positions 1–3, with respective values of 8.61 ± 0.14 g, 9.36 ± 0.06 g, and 8.31 ± 0.05 g.A stronger magnetic field (0.1 T compared to 0.08 T) resulted in higher CF values, especially during measurements in the transverse vector. This effect was most pronounced in the most extended catheter from the sheath ‐ Position 3 (with respective values of 4.54 ± 0.09 g vs. 8.31 ± 0.05 g, p < 0.001). In the sagittal, cranial, and caudal vectors, the differences were less noticeable.ConclusionDifferent magnetic field vectors, catheter extensions from the sheath, and magnetic field strengths result in varying contact force values. For effective radiofrequency ablation lesions, these factors should be considered alongside power, duration, and other established parameters.