bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational and methodological support of preschoolers’ thinking skills development during problem foreign language teaching
Authors:   Bunin Yelets State University, Kartashova Valentina N. , Volynkina Natalia V. ,   N.E. Zhukovsky and Y.A. Gagarin Air Force Academy
Published: March 2021

Introduction. Contemporary requirements to quality improving organizational and methodological support of preschoolers’ thinking skills development in object spatial environment and insufficient development of technological aspect of the problem highlight the search for new pedagogical opportunities among them on the basis of developing potential of children foreign language education.Resolving the contradiction lies in multifunctional substantively rich program creation in this direction and its implementation in the pre-school educational institution. Materials and methods. The study covered 114 (the control group – 57 children, the experimental group – 57 children) Voronezh and Yelets (Russian Federation) preschoolers at the age of 5,5–7,5. To diagnose the development level of imaginatively logical, visibly active and verbally logical thinking skills we used the methods of L.A. Venger, M. I. Ilyina, R. S. Nemov, G. A. Uruntayeva. The results were proved by the χ2-Pearson statistical test. Research results. The quantitative and qualitative review of the experimental teaching statistical data proved the fact that implementation of the authors’ experimental program based on problem teaching and creation of certain pedagogical conditions for preschoolers’ thinking skills stimulation enhance significantly the level of children’s intellectual development during early foreign language education (χ2 = 13,376 > χ20,05). Discussion and conclusion. For the first time a program was created and implementation conditions on the basis of the problem approach were identified. They included different types of children’s’ activity for joint foreign language communicative task performance and stimulated greatly development of preschoolers’ imaginatively logical, visibly active and verbally logical thinking skillsduring problem foreign language teaching. On the basis of the program a tutorially methodical set may be developed which would contribute to improving organizational and methodological support of preschoolers’ thinking skills development.
Perfil dermatoglífico y potencialidades físicas de niñas de gimnasia artística de competencia: Comparación con no gimnastas
Authors: Gastélum-Cuadras Gabriel , Valenzuela-Jurado Felipe , López-Alonzo Salvador Jesús , Chávez-Erives Arturo Iván , Fernandez Aljoe Rahndol 
Published: March 2021

Objetivo: Identificar las potencialidades físicas, a través de perfiles dermatoglíficos, de niñas gimnastas de competencia comparadas con niñas no gimnastas.
Método: Se midieron niñas no gimnastas (n=50) y niñas gimnastas (n=50) participantes en el Campeonato Regional de bases 2018, Zona 1 Norte de México, de los estados de Sonora, Sinaloa, Baja California, Baja California Sur y Chihuahua. Lo anterior a través del método dermatoglífico informatizado, sobre la base del protocolo propuesto por Cummins y Midlo, que consiste en la toma de las huellas de los 10 dedos de las manos.
Resultados: Las gimnastas exhiben mayor coordinación motora, agilidad y resistencia, ya que presentan valores más altos en marcas dactilares como verticilos y delta 10. Absolutamente todas las formulas encontradas en las gimnastas presentan verticilos (coordinación y agilidad), aunque en diferente proporción. Las fórmulas que más se repiten en ambos grupos son presillas > verticilos (gimnastas 48% y no gimnastas 44%) y verticilos > presillas (gimnastas 26% y no gimnasta 16%). Notando que, aunque en las niñas no gimnastas también aparecen dichas formulas, en este grupo tienden a diversificarse de forma clara.
Conclusiones: Se logra definir que los verticilos, que correlacionan con coordinación y agilidad, son huellas de suma importancia en la práctica de la gimnasta, que junto con un delta 10 (promedio) de 14 y un alto conteo de líneas en los dedos de la mano izquierda, como elementos indispensables en el perfil dermatoglífico en la gimnasia.
Influencia de la localización del acelerómetro para cuantificar la actividad física en programas para la prevención de osteoporosis
Authors: Sanchez Trigo Horacio , Sánchez-Oliver Antonio Jesús , Sañudo Borja 
Published: March 2021

Objetivo: La actividad física tiene efectos positivos sobre la salud ósea. Para desarrollar programas de prevención de la osteoporosis basados en actividad física, la intensidad de la misma debe cuantificarse con precisión con el fin de garantizar su efectividad así como la integridad esquelética del individuo. El objetivo ha sido evaluar la influencia de la localización del acelerómetro para cuantificar la intensidad de la actividad física en programas para la prevención de osteoporosis.
Método: Dieciocho mujeres premenopáusicas completaron un protocolo de ejercicio compuesto por cinco saltos con contramovimiento y cuatro series en tapiz rodante a distintas velocidades. Las participantes portaron acelerómetros situados en muñeca y cadera, y se compararon las medidas de aceleración registradas en ambas localizaciones. Se realizaron tres tipos de análisis: 1) Asociación entre mediciones de ambas localizaciones. 2) Nivel de similitud en las estimaciones grupales. 3) Evaluación del sesgo de medición.
Resultados: Baja correlación entre medidas de aceleración registradas en muñeca y cadera en todas las pruebas de protocolo (r= 0.046-0.469, p<0.05). Las diferencias entre las estimaciones grupales y el sesgo de medición aumentan a medida que se incrementa la velocidad en el tapiz rodante.
Conclusiones: La aceleración medida en la muñeca podría sobreestimar la aceleración realmente producida en la cadera. Este efecto debe tenerse en cuenta a la hora de cuantificar la carga en programas de actividad física para la prevención de la osteoporosis.
Causas de la lesión de isquiosurales en fútbol: Una revisión bibliográfica desde las etapas formativas hasta la profesional
Authors: Jiménez-Sánchez Hodei , Bazuelo Ruiz Bruno 
Published: March 2021

Objetivos: identificar las principales causas de lesión de isquiosurales en las diferentes etapas de formación, desde la etapa sub-12 hasta la etapa profesional, y establecer la influencia de la lesión previa de isquiosurales como causa principal de sufrir una nueva lesión.
Método: la búsqueda bibliográfica se realizó en Dialnet, Pubmed, Web of Science, Scopus y SportDISCUS, entre las fechas de enero de 2010 hasta mayo de 2020.
Resultados: la búsqueda concluyó que el patrón de lesión isquiosural más concurrido es el de jugador de edad avanzada, con mayores valores de fuerza y menores valores de flexibilidad, y con un mayor grado de anteversión pélvica. El envejecimiento, los movimientos compensatorios en patrones motores fundamentales y otros factores de la competición se presentaron como las principales causas de lesión en jugadores profesionales.
Conclusiones: la lesión previa, con el mayor número de casos registrados de incidencia lesional, se estableció como principal factor de riesgo de lesión de la musculatura isquiosural.
MODERN ARAP EDEBİYATINDA MUÂRAZA: AHMED ŞEVKÎ-HÂŞİM er-RİFÂÎ ÖRNEĞİ
Authors: YILDIZ Ahmet 
Published: March 2021

Modern Mısır edebiyatında Nahda şairleri arasında sayılan Ahmed Şevkî (ö. 1932), şiirlerinde klasik Arap edebiyatı üslubunu kullanmış güçlü bir ediptir. Şiirleriyle Mısır halkının duygularına tercüman olan Şevkî, pek çok şairi etkilemiştir. Hâşim er-Rifâî (ö. 1959) de bunlardan biridir. 1935 yılında doğan, yaşadığı dönemin siyasî olaylarında İslâmcı duruşuyla tanınan ve bu nedenle komünistler tarafından bir hedef hâline gelen Hâşim, 1959 yılında öldürülmüştür. Erken yaşlarda şiir yazmaya başlayan Hâşim, ardında bir şiir divanı bırakmış, Şevkî gibi tiyatro yazmış ve onun bazı kasidelerine muârazalar yapmıştır. Bu çalışmada, Hâşim’in divanında yer alan Nehcü’l-Bürde, Mevlidü’n-Nûr ve el-Ezher isimli kasideler incelenmiştir. Bu üç kaside isimlendirme, revî harfi, kafiye, vezin, muhteva ve beyit sayısı yönünden ele alınmış, nazîreleri olan Ahmed Şevkî’ye ait kasidelerle karşılaştırılmış, Şevkî’nin şiirlerinin, Hâşim’in şiirlerine etkisi tespit edilmiştir. Böylece câhiliye döneminden beri var olan muâraza sanatının 20. yüzyıldaki örnekleri incelenerek, bir şairin şiirinde kullandığı şekil ve muhtevanın, diğer şairlerin eserlerine etkisi göz önüne serilmiştir.Bu makale için 06-10-2021 tarihinde bir düzeltme yayınlandı. https://dergipark.org.tr/tr/pub/daad/issue/65219/1003205
SUPRAORBITAL CRANIOTOMY APPROACH IN ENDOCRINE-INACTIVE PITUITARY ADENOMAS
Authors: Valea Ana , Turturea Roxana , Botezan Oana , Moldovan Cristina , Carsote Mara 
Published: March 2021

A non-functioning pituitary adenoma is one of the most common endocrine tumors with a benign pattern in the majority of cases. We present the case of a 69 years old female admitted to the endocrinology department for visual field defects, dizziness, memory disorder, bradylalia, bradypsychia. During the medical examination, the patient presented a syncopal event, with abundant sweating and temporo-spatial disorientation. Magnetic Resonance Imaging revealed a pituitary macroadenoma of 23/33.3/37 mm with two spherical lesions overlapped (“snowman” shape), with mass effect on the cavernous sinuses extending to the posterior wall of the left sphenoid sinus. Visual field examination showed significant narrowing to both eyes. The hormonal profile revealed gonadotropic insufficiency and low Insulin-like Growth Factor 1 with normal prolactin and cortisol levels. Thyroid hormonal evaluation highlighted primary hypothyroidism due to autoimmune thyroiditis. Two weeks later, adenomectomy was performed by supraorbital craniotomy. After discharge, she received the thyroid hormone replacement therapy initiated preoperatively and specific therapy for associated pathology: diabetes mellitus type 2, osteoporosis, and hyperlipidemia. Pituitary surgery is the first line treatment for the majority of patients with symptomatic endocrine-inactive adenomas. A further multidisciplinary close check-up is periodically recommended.
THE MARK OF THE DURATION OF SURGERY ON THE POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH COMPLICATED COLON CANCER
Authors: Mihailov Raul , Serban Cristina , Beznea Adrian , Firescu Dorel , Constantin Georgiana Bianca , Rebegea Laura , Voicu Dragos , Mihailov Oana , Patrascu Traian 
Published: March 2021

Postoperative complications are common in patients with complicated colon cancers operated in Emergency. Most complications are those of the sound (suppurations, hematoma, dehiscence), postoperative ileus, anastomotic fistula. The purpose of this study is to evaluate the influence of the duration of the surgery on the postoperative complications in patients with complicated colon tumors, operated in emergency. We made a retrospective study on 451 patients treated for complicated colon cancers in the surgery clinics I and II of the Clinical Emergency County Hospital Galați between 2008 and 2017. In this study, we found all the 3 types of complications of colon tumors, but the most common was the intestinal obstruction. The operations varied from colostomies to subtotal and total colectomies. Most complications occured on the postoperatory days 4-8. The statistical analysis that we made revealed important statistical significance in the correlation of the postoperative complications and the duration of the surgical intervention (p value less than 0,001).The emergency colon cancer surgery has a high rate of postoperative complications, of which the most common are cardio-respiratory, parietal and fistulous. Their occurrence is directly influenced by the duration of the surgery.
Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages
Authors: Zhang Xinmei , Li Chao , Cao Weijun , Zhang Zhenyu 
Published: March 2021

ObjectiveMicrobial infections have been shown to contribute to gastric carcinogenesis, the knowledge of gastric microbiota alteration in this process may provide help in early diagnosis of gastric cancer. The aim of this study was to characterize the microbial changes and identify taxonomic biomarkers across stages of gastric carcinogenesis.MethodsThe gastric microbiota was investigated by 16S rRNA gene analysis in gastric mucosal specimens from 47 patients including superficial gastritis (SG), atrophic gastritis (AG), gastric intraepithelial neoplasia (GIN), and gastric cancer (GC). Differences in microbial composition across the disease stages, especially in GIN and GC were assessed using linear discriminant analysis effect size.ResultsThere was no gradual changing trend in the richness or diversity of the gastric microbiota across stages of gastric carcinogenesis. The relative abundance of dominant taxa at phylum and genus levels didn’t show a gradual shift pattern, and the only four taxa that continuously enriched from SG to GC were Slackia, Selenomonas, Bergeyella, and Capnocytophaga, all of which were oral bacteria. The most representative taxa which were enriched in GC patients were oral bacteria including Parvimonas, Eikenella and Prevotella-2, and environmental bacteria including Kroppenstedtia, Lentibacillus, and Oceanobacillus. The gastric microbiota in GIN patients were characterized by enrichment of intestinal commensals including Romboutsia, Fusicatenibacter, Prevotellaceae-Ga6A1-group, and Intestinimonas. Gastric cardia cancer and non-cardia cancer patients had significantly different microbiota profiles characterized by a higher abundance of Helicobacter in the cardia cancer patients.ConclusionsOur results provide insights on potential taxonomic biomarkers for gastric cancer and precancerous stages, and suggest that gastric microbiota might play different roles in the carcinogenesis of cardia cancer and non-cardia cancer.
Triple Oxygen Isotope Measurements by Multi-Collector Secondary Ion Mass Spectrometry
Authors: Bouden Nordine , Villeneuve Johan , Marrocchi Yves , Deloule Etienne , Füri Evelyn , Gurenko Andrey , Piani Laurette , Thomassot Emilie , Peres Paula , Fernandes Firmino 
Published: March 2021

Secondary ion mass spectrometry (SIMS) is a powerful technique for in situ triple oxygen isotope measurements that has been used for more than 30 years. Since pioneering works performed on small-radius ion microprobes in the mid-80s, tremendous progress has been made in terms of analytical precision, spatial resolution and analysis duration. In this respect, the emergence in the mid-90s of the large-radius ion microprobe equipped with a multi-collector system (MC-SIMS) was a game changer. Further developments achieved on CAMECA MC-SIMS since then (e.g., stability of the electronics, enhanced transmission of secondary ions, automatic centering of the secondary ion beam, enhanced control of the magnetic field, 1012Ω resistor for the Faraday cup amplifiers) allow nowadays to routinely measure oxygen isotopic ratios (18O/16O and 17O/16O) in various matrices with a precision (internal error and reproducibility) better than 0.5‰ (2σ), a spatial resolution smaller than 10 µm and in a few minutes per analysis. This paper focuses on the application of the MC-SIMS technique to the in situ monitoring of mass-independent triple oxygen isotope variations.
Evidence of Surface Rupture Associated With Historical Earthquakes in the Lower Tagus Valley, Portugal. Implications for Seismic Hazard in the Greater Lisbon Area
Authors: Canora Carolina , Vilanova Susana P. , De Pro-Diáz Yolanda , Pina Pedro , Heleno Sandra 
Published: March 2021

The Lower Tagus Valley Fault, Portugal, has long been associated with the damaging earthquakes that affected the Greater Lisbon Area in historical times. These include a poorly documented earthquake that occurred in 1344, the relatively well-documented 1531 earthquake, and the most recent M6.0 1909 earthquake. In this work, we use a 0.5 m resolution LiDAR-based digital elevation model and a 0.5 cm resolution digital surface model based on UAV photogrammetry to accurately locate the fault scarps in the northernmost portion of the western fault strand and to select sites to perform paleoseimolological investigations. The paleoseismological and geochronological analysis performed in the Alviela trench site document the fault activity in the last 3000 years, including two earthquakes during historical times. We performed ground motion scenarios for 20 km, 40 km, and 60 km ruptures including the trench site. The ground motion fields obtained for the 40 km and 60 km ruptures are in agreement with most macroseismic intensity data available for the 1531 earthquake, implying a magnitude in the range M6.8–7.4. However, the degree of deformation preserved in the trench suggests a value closer to the lower magnitude bound. The intensity level observed in Lisbon in 1531 (IX) is lower than the modeled intensities for all considered scenarios and could be related to a particularly high level of vulnerability of the building stock.
Continuous Positive Airway Pressure Improves Renal Function in Obese Patients With Obstructive Sleep Apnea Syndrome
Authors: Perticone Maria , Maio Raffaele , Scarpino Paola Elisa , Mancuso Luana , Volpentesta Mara , Caroleo Benedetto , Suraci Edoardo , Sciacqua Angela , Sesti Giorgio , Perticone Francesco 
Published: March 2021

Background:Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular morbidity and mortality, and it has a detrimental effect on renal function. Obesity is the major risk factor for OSAS, and represents a risk factor for chronic kidney disease. Continuous positive airway pressure (CPAP) is the suggested therapy for moderate-to-severe OSAS. We designed this study to evaluate the effect of CPAP on estimated glomerular filtration rate (e-GFR) in a cohort of obese patients with moderate-to-severe OSAS and normal renal function.Methods:We enrolled 198 obese subjects, divided into two groups (OSAS+ and OSAS–), on the basis of cardiorespiratory monitoring; mild OSAS patients (n= 33) were excluded from the study, thus the analyses were conducted on 165 patients. Comparisons between groups were made by Studentt-test or χ2test as appropriate. Linear regression analyses were used to assess the relationship between baseline e-GFR and different covariates and, in the OSAS+ group, between Δe-GFR and different covariates. A multivariate regression analysis was performed to determinate the independent predictor of the Δe-GFR.Results:OSAS+ subjects showed significantly increased values of systolic blood pressure, HOMA, pulse wave velocity, high-sensitivity C reactive protein and uric acid compared with OSAS– group. OSAS+ group showed significantly lower values of e-GFR and increased values of microalbuminuria. At linear regression analysis e-GFR resulted significantly and inversely related to AHI in the whole study population and in the two groups. After 6 months of CPAP therapy, OSAS+ subjects showed an improvement in respiratory parameters, as well as a significant increase in e-GFR values (104.2 + 19.0 vs. 84.0 + 13.1 ml/min/1.73 m2,P&lt; 0.0001). At multiple regression analysis, Δ apnea/hypopnea index (AHIa) resulted the main independent predictor of Δe-GFR explaining 22% of its variation.Conclusions:Obese OSAS patients show significantly lower values of e-GFR, even if in the normal range, compared with obese non-OSAS subjects. After 6 months of CPAP, e-GFR significantly improved (+20 ml/min/1.73 m2) and ΔAHIa resulted the most important independent predictor of Δe-GFR.
Adiponectin-Transfected Endothelial Progenitor Cells Have Protective Effects After 2-Hour Middle-Cerebral Artery Occlusion in Rats With Type 2 Diabetes Mellitus
Authors: Wang Meiyao , Li Yan , Zhang Renwei , Zhang Shuaimei , Feng Hongliang , Kong Zhaohong , Aiziretiaili Nadire , Luo Zhengjin , Cai Qi , Hong Yan , Liu Yumin 
Published: March 2021

Objectives: This present study aimed to examine the effects of adiponectin-transfected endothelial progenitor cells (LV-APN-EPCs) on cerebral ischemia–reperfusion injury in rats with type 2 diabetes mellitus (T2DM) and to explore the underlying mechanisms.Methods: Seventy male Sprague–Dawley rats with T2DM were randomly divided into sham, phosphate-buffered saline (PBS), LV-APN-EPCs, LV-EPCs, and EPCs groups. Transient middle cerebral artery occlusion (MCAO) was induced by the intraluminal suture method. After 1 h of reperfusion, the five interventions were performed by tail-vein injections. The modified neurological severity score (mNSS) was used to assess neurological function before and on days 1, 7, and 14 after MCAO. After 14 days, magnetic resonance imaging scanning, hematoxylin and eosin staining, terminal dUTP nick-end labeling staining, Western blotting analysis, cluster of differentiation (CD) 31 immunofluorescence, and enzyme-linked immunosorbent assay were used to evaluate infarct rate, morphological damage, cell apoptosis, and microvessel density.Results: Compared with PBS, LV-EPCs, and EPCs groups, the LV-APN-EPCs group showed significantly lower mNSS score, lower infarct rate, and less morphological damage (all P &lt; 0.05). In addition, compared with other groups, the LV-APN-EPCs group had significantly increased levels of B cell lymphoma/leukemia-2 (Bcl-2) protein, CD31+ microvessels, endothelial nitric oxide synthase, and vascular endothelial growth factor, and decreased levels of Bcl-2-associated X protein and neuronal apoptosis in the peri-infarct cortex (all P &lt; 0.05).Conclusion: These results suggest that LV-APN-EPCs exert protective effects against cerebral ischemia–reperfusion injury in T2DM rats by increasing angiogenesis.
High Expression of CLEC11A Predicts Favorable Prognosis in Acute Myeloid Leukemia
Authors: Yin Chengliang , Zhang Junyan , Guan Wei , Dou Liping , Liu Yuchen , Shen Ming , Jia Xiaodong , Xu Lu , Wu Rilige , Li Yan 
Published: March 2021

BackgroundAcute myeloid leukemia (AML) is a heterogeneous disease of the hematopoietic system, for which identification of novel molecular markers is potentially important for clinical prognosis and is an urgent need for treatment optimization.MethodsWe selected C-type lectin domain family 11, member A (CLEC11A) for study via several public databases, comparing expression among a variety of tumors and normal samples as well as different organs and tissues. To investigated the relationship between CLEC11A expression and clinical characteristics, we derived an AML cohort from The Cancer Genome Atlas (TCGA); we also investigated the Bloodspot and HemaExplorer databases. The Kaplan-Meier method and log-rank test were used to evaluate the associations between CLEC11A mRNA expression, as well as DNA methylation, and overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS). DNA methylation levels of CLEC11A from our own 28 de novo AML patients were assessed and related to chemotherapeutic outcomes. Bioinformatics analysis of CLEC11A was carried out using public databases.ResultsMultiple public databases revealed that CLEC11A expression was higher in leukemia. The TCGA data revealed that high CLEC11A expression was linked with favorable prognosis (OS p-value = 2e-04; EFS p-value = 6e-04), which was validated in GSE6891 (OS p-value = 0; EFS p-value = 0; RFS p-value = 2e-03). Methylation of CLEC11A was negatively associated with CLEC11A expression, and high CLEC11A methylation level group was linked to poorer prognosis (OS p-value = 1e-02; EFS p-value = 2e-02). Meanwhile, CLEC11A hypermethylation was associated with poor induction remission rate and dismal survival. Bioinformatic analysis also showed that CLEC11A was an up-regulated gene in leukemogenesis.ConclusionCLEC11A may be used as a prognostic biomarker, and could do benefit for AML patients by providing precise treatment indications, and its unique gene pattern should aid in further understanding the heterogeneous AML mechanisms.