bluuebunny/crossref_metadata_2025_split huggingface dataset:
CBX3 Is a Prognostic Biomarker That Is Correlated With Lymphocyte Infiltration in Hepatocellular Carcinoma
Authors: Zhang Jia-Ning , TAO Qi fei , Ding Dong yang , YANG YUAN , Zhou Wei-Ping 
Published: September 2021

Abstract
Background: CBX3 is a key gene that is involved in immune cell regulation, however, its prognostic values and its correlation with infiltrating lymphocytes in various cancers have not been clearly established. This study aims to investigate the role CBX3 in hepatocellular carcinoma (HCC).Methods: We first reviewed the expression of CBX3 in different cancers and adjacent tissues using oncomine database. Next, the authors focus on the expression of CBX3 in hepatocellular carcinoma. Therefore, the expression of CBX3 in hepatocellular carcinoma were analyzed through UALCAN online analysis website and the Human Protein Atlas (www.proteinatlas.org) website. In addition, we further found that CBX3 can be identified as an effective marker for the prognostic guidance of hepatocellular carcinoma according to the Kaplan-Meier plotter database and the Bioinformatics analysis online websites (www.aclbi.com). Next, we used the Bioinformatics analysis online websites to explore whether the expression level of CBX3 in liver cancer is related to the infiltration of certain immune cells. In addition, we also predicted the correlation between immune checkpoint and CBX3 in liver cancer.Results: The analysis results preliminarily show that CBX3 be expressed abnormally in many cancers, and CBX3 was significantly up-regulated in HCC. The high expression of CBX3 indicated survival outcomes and it showed a huge potential as a effective marker for the prognostic guidance of hepatocellular carcinoma. Furthermore, we found that CBX3 in liver cancer is related to the infiltration of certain immune cells, including CD4+ T cells, macrophages and B cells. In addition, the results showed HAVCR2 is most likely to become an effective immune checkpoint for HCC patients immunotherapy with high CBX3 expression.Conclusions: CBX3 is a potential diagnostic and prognostic marker in HCC and related to the infiltration of certain immune cells. It is expected to become a breakthrough point in immunotherapy in the future.
Prediction of Hemorrhagic Transformation and Functional Prognosis in Patients With Acute Ischemic Stroke Using One-stop CT Examination: A Study on the Plateau Region of China
Authors: Li Meng , Hu Huiying , Li Weixia , Bai Chengpin , Bai Xin , Wang Xueyan , Wu Yousen , Lu Guangshun , Bao Haihua 
Published: September 2021

Abstract
There are few studies on the early hemorrhagic transformation of ischemic stroke in plateau area. This study aimed to analyze the value of one-stop CT in predicting HT and functional outcomes in patients with acute ischemic stroke (AIS) caused by occlusion of great vessels before treatment in the high plateau region. Data were obtained from patients who underwent non-enhanced CT (NCCT), CTP and CTA examination within 24 hours from October 2019 to December 2020. Follow-up CT/MRI was performed within one month to determine if HT occurred later. The clinical data, laboratory results and imaging data of patients with and without HT were compared. Of the 74 patients included, 32(43.3%) had HT during follow-up, and HT was more likely to occur in poor collateral circulation (p = 0.029). The values of MTT, Tmax, PS, rCBV, rMTT, rPS in HT group were higher than those in non-HT group (p < 0.05). The results showed that PS > 1.315 ml/100 g/min (AUC, 0.753, p = 0.001) and rCBV > 1.470(AUC, 0.764; p=0.001) had better diagnostic value for HT. One-stop CT examination was performed before treatment in patients with AIS. Quantitative perfusion parameters and multi-phase CTA were used to evaluate the prognosis of HT after recanalization of proximal great vessels.
Improving Animal-Specific Radiotherapy Quality Assurance For Kilovoltage X-Ray Radiotherapy Using A 3D Printed Dog Skull Water Phantom
Authors: Tanabe Yoshinori , Iseri Toshie , Onizuka Ryouta , Ishida Takayuki , Eto Hidetoshi , Nakaichi Munekazu 
Published: September 2021

Abstract
Accurate dose assessment during animal radiotherapy is beneficial for veterinary medicine and medical education. We evaluated the dose distributions of kilovoltage X-ray orthovoltage radiotherapy and created a dog skull water phantom for animal-specific radiotherapy. EGSnrc-based BEAMnrc and DOSXYZnrc codes were used to simulate orthovoltage dose distributions. At 10, 20, 30, 40, 50 and 80 mm in a water phantom, depth dose was measured with waterproof Farmer dosimetry chambers and the diagonal off-axis ratio was measured with Gafchromic EBT3 film to simulate orthovoltage dose distributions. Energy differences between orthovoltage and linear accelerated radiotherapy were assessed with a heterogeneous bone and tissue virtual phantom. The animal-specific phantom for radiotherapy quality assurance was created from CT scans of a dog and printed with a three-dimensional printer using polyamide 12 nylon, with insertion points for dosimetry chambers and Gafchromic EBT3 film. Monte Carlo simulated and measured dose distributions differed by no more than 2.0% along the central axis up to a depth of 80 mm. The anode heel effect occurred in shallow areas. The orthovoltage radiotherapy percentage depth dose in bone was >40%. Build-up was >40%, with build-down after bone exit, whereas linear accelerator radiotherapy absorption changed little in the bone. A highly water-impermeable, animal-specific dog skull water phantom could be created to evaluate dose distribution.Animal-specific water phantoms and Monte Carlo simulated pre-treatment radiotherapy is useful quality assurance for orthovoltage radiotherapy and yields a visually familiar phantom that will be useful for veterinary medical education.
Nutritional Surveillance in Brazil: Challenges and Opportunities. A Mixed-Method Research to Assess the Brazilian Sisvan System
Authors: Nasser Gabriela , Maun Andy 
Published: September 2021

Abstract
Background: As countries currently face growing malnutrition trends (often with a double burden of malnutrition), data on the nutritional status of the population can provide support to local policies, as well as track progress towards goals, such as the global nutrition targets. Brazil has a national nutritional surveillance system (Sisvan), which provides nutritional status data for municipalities, on all age groups. In an effort to offer a more in-depth analysis of the Sisvan, this study investigated the strengths and limitations of the system regarding the available data on children to explore its contribution to the health information system and policy making potential. Methods: A mixed methods approach was used innovatively, with triangulation of results, to combine quantitative descriptive statistics (to determine national coverage and completeness of nutritional status data among children in the Sisvan between 2008 and 2018), with a qualitative phenomenographic analysis of in-depth interviews with stakeholders involved with the system. Results: Results demonstrated on average an increase in coverage within the system of the nutritional status of children nationally from 14% in 2008 to 35,8% in 2018, with variability in this growth over the different areas of the country. The interviews demonstrated that the Sisvan is a tool to improve health conditions that go beyond nutrition. It has the potential to be integrated in a greater structure of Public Health care. After triangulation of results, there was agreements between the quantitative and qualitative analysis, demonstrating that the surveillance system is embedded in the Primary Health Care strategy, albeit current limitations. Conclusion: The Sisvan has the potential to be an important tool for the monitoring of nutritional targets and provision of information for local and national health and nutrition policies. However, more integration between the several instances involved is still a gap, for a full usage of the system and the generated data.
Optimal Initial Intravenous Diuretic Dose for Acute Decompensated Heart Failure: Insights from the REALITY- AHF
Authors: Yoshioka Kenji , Maeda Daichi , Okumura Takahiro , Kida Keisuke , Oishi Shogo , Akiyama Eiichi , Suzuki Satoshi , Yamamoto Masayoshi , Mizukami Akira , Kuroda Shunsuke , Kagiyama Nobuyuki , Yamaguchi Tetsuo , Sasano Tetsuo , Matsumura Akihiko , Kitai Takeshi , Matsue Yuya 
Published: September 2021

Abstract
Although intravenous diuretics is a cornerstone of acute heart failure treatment (AHF), its optimal initial dose is unclear. This is a post-hoc analysis of the REALITY-AHF, a prospective multicentre observational registry of AHF. The initial intravenous diuretic dose used in each patient was categorised into below, standard, or above the recommended dose groups according to guideline-recommended initial intravenous diuretic dose. The recommended dose was individualised based on the oral diuretic dose taken at admission. We compared the study endpoints, including 60-day mortality, diuretics response within six hours, and length of hospital stay (HS). Of 1,093 patients, 429, 558, and 106 were assigned to the Below, Standard, and Above groups, respectively. The diuretics response and HS were significantly greater in the Below group than in the Standard group after adjusting for covariates. Kaplan-Meier analysis indicated a significantly higher incidence of 60-day mortality in the Above group than the Standard group. This difference was retained after adjusting for other prognostic factors. Treatment with a lower than guideline-recommended intravenous diuretic dose was associated with longer HS, whereas above the guideline-recommended dose was associated with a higher 60-day mortality rate. Our results reconfirm that the guideline-recommended initial intravenous diuretic dose is feasible for AHF.
Epigenetic Marker of Telomeric Age is Associated with Exacerbations and Hospitalizations in Chronic Obstructive Pulmonary Disease
Authors: Cordero Ana I Hernández , Yang Chen Xi , Li Xuan , Milne Stephen , Chen Virginia , Hollander Zsuzsanna , Ng Raymond , Criner Gerard J. , Woodruff Prescott G. , Lazarus Stephen C. , Connett John E. , Han MeiLan K. , Martinez Fernando J. , Reed Robert M. , Man S. F. Paul , Leung Janice M , Sin Don 
Published: September 2021

Abstract
Background: Chronic obstructive pulmonary disease (COPD) is an age-related condition that has been associated with early telomere attrition; the clinical implications of telomere shortening in COPD are not well known. In this study we aimed to determine the relationship of the epigenetic regulation of telomeric length in peripheral blood with the risk of exacerbations and hospitalization in patients with COPD. Methods: Blood DNA methylation profiles were obtained from 292 patients with COPD enrolled in the placebo arm of the Macrolide Azithromycin to Prevent Rapid Worsening of Symptoms Associated With Chronic Obstructive Pulmonary Disease study (MACRO) and who were followed for 1-year. We calculated telomere length based on DNA methylation markers (DNAmTL) and related this biomarker to the risk of exacerbation and hospitalization and health status (St. George respiratory questionary score [SGRQ]) over this time using a Cox proportional hazards model. We also used linear models to investigate the associations of DNAmTL with the rates of exacerbations and hospitalizations (adjusted for chronological age, lung function, race, sex, smoking, and body mass index).Results: Participants with short DNAmTL demonstrated increased risk of exacerbation (P=0.02) and hospitalization (P=0.03) compared to those with longer DNAmTL. DNAmTL age acceleration was associated with higher rates of exacerbation (P=1.35x10-04) and hospitalization (P=5.21x10-03) and poor health status (SGRQ) independent of chronological age (P=0.03).Conclusion: Telomeric age based on blood DNA methylation is associated with COPD exacerbation and hospitalization and thus is a promising biomarker for poor outcomes in COPD.
Profile and Triage Appropriateness of Trauma Patients Triaged Green: A Prospective Cohort Study from a Secondary Care Hospital in India
Authors: Anthony Aroke Anna , Dutta Rohini , Sarang Bhakti , David Siddarth , O'Reilly Gerard , Raykar Nakul , Khajanchi Monty , Attergrim Jonatan , Soni Kapil Dev , Sharma Naveen , Mohan Monali , Gadgil Anita , Roy Nobhojit , Wärnberg Martin Gerdin 
Published: September 2021

Abstract
Introduction: Triage is an important component of in-hospital trauma care for adequate patient management and to avoid overcrowding in emergency departments (ED). Prioritising the evaluation of non-urgent patients may result in the diversion of workforce from patients requiring immediate care. However, not evaluating these patients may result in missed injuries and poor outcomes. We aimed to evaluate the profile of these non-urgent patients triaged ‘green’, as part of a triage-trial in a secondary-care hospital in India and validate this against the Cape Triage Score (CTS).Methods: We analysed data of patients triaged green in a prospective single-centre cohort study between July 2016 to November 2019. Clinicians at this triage-naive ED were introduced to a triage trial who then assigned a triage category to trauma patients, aged 18 years and above, on initial evaluation. Telephonic follow-up was performed for all patients included in the study. Triage appropriateness was retrospectively analysed using the CTS. Results: We included 4135 trauma patients triaged green. The mean age of patients was 32.8 (±13.1) years, 77% males. The median (IQR) length of stay of admitted patients was 3 (13) days. Half the patients had a mild Injury Severity Score (3-8), with the majority of injuries being blunt (98%). Of the patients triaged green, 97% came in as direct arrivals and 94.4% were discharged from the ED after initial evaluation. As per CTS, nearly three-quarters (74%) of patients were undertriaged ‘green’ by the clinicians in a triage-naive ED. Conclusion: ​​ Three-fourths (74%) of the patients triaged green by clinicians in a secondary care hospital in Mumbai were mistriaged when retrospectively analysed using CTS. This highlights the need for implementation and evaluation of trauma triage training for the in-hospital first responders (clinicians, nurses and other paramedical staff) in the EDs.
Socially Induced False Memories in the Absence of Misinformation
Authors: Wagner Ullrich , Echterhoff Gerald 
Published: September 2021

Abstract
Ample evidence shows that post-encoding misinformation from others can induce false memories. Here, we demonstrate in two experiments a new, tacit form of socially generated false memories, resulting from interpersonal co-monitoring at encoding without communication of misinformation. Pairs of participants jointly viewed semantically coherent word lists, presented successively in blue, green, or red letters. Each individual was instructed to memorize words presented in one of the colors. One color remained unassigned (control condition). Participants reported more false memories for non-presented words (lures) semantically related to partner-assigned than to control lists, although both list types were equally irrelevant to their own task. Notably, this effect also persisted for particularly rich memories. These findings show for the first time that social induction of false memories, even subjectively rich ones, does not necessarily require communication of deceptive information. This has important implications both theoretically and practically (e.g. in forensic contexts).
In Vivo Study of a Newly Synthesized Chromen-4-One Derivative as an Antitumor Agent Against HCC
Authors: Nabeel Asmaa Ismail , Mansour somaya Z , Mahdy El-Sayed M. E. , El-Mezayen Hatem , Mohamed Sarah Ali 
Published: September 2021

Abstract
Background: Chromenes are a wide group of natural compounds that can be synthesized chemically. The chromen-4-one nucleus acts as a skeleton for varieties of additional active groups that makes the chromenes activity varies between antioxidant and anti-inflammatory agents. In the present study, a newly synthesized chromene compound exhibits different behavior other than anti-inflammatory and antioxidant activities that it is the first time that a member of chromen-4-one compound can control the cancer progress. Inflammation is the first step in tumor development where the severity grade can potentiate tumor growth and progression. In many tumors pro-inflammatory genes record high expression level such as tumor necrosis factor (TNF-α) and vascular endothelial growth factors (VEGF). These pro-inflammatory factors act as rate limiting steps in tumor initiation and controlling its expression acts as an early therapeutic way to control the tumor proliferation. The chromone derivatives have biological activities such as anti-inflammatory and antitumor activity. Methods: In the present study a new chromene derivative (Ch) was studied against HCC induced by diethylnitrosamine (DEN) in rats. Results: The treatment strategy Ch compound is to down regulate pro-inflammatory gene expression of early genes as TNF-α as well as VEGF and subsequently controls other factors such as p53, Cyt C and MMP-9. Also, retrieve the balance between Bcl2 and Bax proteins in DEN induced HCC in rats. Conclusion: The ability to control the primary initiators of HCC offers the new Ch derivative an antitumor activity and encourages further researches to follow and monitor its effect on the molecular level.
Laser Oscillating of Nickel Alloyed Welds on Press-hardened Steel
Authors: Sun Qian , Zhang Zhenghui , Wang Xiaonan , Zhang Qingyu , Liu Zhenguang 
Published: September 2021

Abstract
Laser oscillating welding was employed to fabricate Al-Si coated press-hardened steel (PHS) to improve the element homogeneity in the fusion zone. Three oscillation amplitudes that are 0 mm, 0.5 mm and 1.3 mm were studied in this present. Ni foil of 0.06 mm thickness was used as an interlayer between two tailored PHS welded. Welds defects was absent for any oscillation amplitudes, and weld width increased with increasing oscillation amplitudes. Compared to linear laser welding, Ni and Al had an uneven elemental profile due to strong stirring force, full martensite was achieved in fusion zone. However, δ-ferrite was present with oscillation amplitudes increased to 1.3 mm, since Ni content had a sharp descent compared to Al. Tensile srtength of welded joints was not influnced by altering oscillation amplitudes.
Police Officers' Perception of Mentally Disordered People: A National Survey in Japan
Authors: Shiina Akihiro , Niitsu Tomihisa , Tomoto Aika , Iyo Masaomi , Shimizu Eiji , Fujii Chiyo 
Published: September 2021

Abstract
BackgroundsThe treatment of mentally disordered offenders is an issue in forensic mental health. In most countries, police officers working in the community are the first to deal with patients at risk of harming themselves or others. However, their perceptions and opinions regarding forensic mental health have not been adequately investigated in Japan.MethodsWe conducted a national survey to gather police officers' views regarding legislation on mentally disordered people and inter-organizational collaboration.ResultsA total of 241 police officers participated in this study. Many participants were aware of the mental health care scheme in their daily work. Contrastingly, many participants complained about the public health center and psychiatrists. They seem to have emerged partially from the differences in each organization's structure, lack of resources, and communication gaps. Many participants felt a lack of opportunity to learn about psychiatry.ConclusionBetter collaborative care for mentally disordered people requires mutual relationships among the police, public health centers, and psychiatrists with a deeper understanding of community mental health.
Acquired Drug Resistance During the Turnaround Time for Drug Susceptibility Testing Impacts Outcome of Tuberculosis
Authors: Zhu Jiahui , Forsman Lina Davies , Bao Ziwei , Xie Yan , Ning Zhu , Li Xuliang , Hoffner Sven , Hu Yi 
Published: September 2021

Abstract
BackgroundThe impacts of acquired resistance to first-line drugs (FLDs) during turnaround time (TAT) for drug susceptibility testing (DST) are still unclear. Thus, we aimed to investigate the impacts of acquired resistance to FLDs during TAT for DST on tuberculosis (TB) standard treatment.MethodWe performed a prospective cohort study between 2013 and 2018 in China, including sputum culture-positive TB patients with a baseline DST result for a Mycobacterium tuberculosis (Mtb) isolate collected at TB diagnosis and a follow-up DST result for a Mtb isolate collected when baseline DST result became available. Mtb isolates with acquired drug resistance were identified by the comparison between baseline and follow-up DST. Treatment outcome were evaluated by sputum culture conversion and World Health Organization (WHO) treatment outcome definitions. ResultsIn total, 65 patients with Mtb isolates with acquired resistance to any FLDs and 130 patients with consistent drug susceptibility profile were included in the analysis. In a Cox proportional hazard regression analysis, acquired pyrazinamide-resistance (aHR 0.54, 95%CI: 0.36-0.81) and acquired isoniazid-resistance (aHR 0.50, 95%CI: 0.29-0.85) were associated with prolonged time to sputum culture conversion. Furthermore, independent risk factors of treatment failure included acquired INH-resistance (aOR 7.64, 95%CI: 2.39-16.08) and acquired PZA-resistance (aOR 5.71, 95%CI: 2.31-14.12).ConclusionThe association between acquisition of drug resistance and treatment outcome highlights the importance of shortening the turnaround time of DST.
Large tumour cell group, combinations of CMYC+ or PD-1+ tumour cells and intense PD-L1+ cell reaction are important prognostic factors in nodal T-cell lymphomas with T follicular helper markers
Authors: Mihashi Yasuhito , Kimura Shoichi , Iwasaki Hiromi , Oshiro Yumi , Takamatsu Yasushi , Kawauchi Shigeto , Shimajiri Shohei , Ishizuka Kenji , Takeshita Morishige 
Published: September 2021

Abstract
Background

The clinicopathological characteristics and prognostic factors in nodal T-cell lymphomas with T follicular helper markers (TFH+) are not adequately investigated.
Methods

Immunohistologically, we selected 22 patients with TFH + lymphoma in 47 of peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS), and subclassified into large and small cell groups. We compared the two groups with 39 angioimmunoblastic T-cell lymphoma (AITL) and seven follicular T-cell lymphoma (F-TCL) patients. Prognostic factors were analysed by overall survival in patients with three types of TFH + lymphomas.
Results

Thirteen large cell and nine small cell PTCL patients had more than two TFH markers including programmed cell death-1 (PD-1). Large cell TFH + PTCL showed CMYC expression in 10 patients (76.9%), and four of 11 large cell group (36.4%) had somatic RHOA G17V gene mutation by Sanger sequencing. In TFH + lymphomas, large cell TFH + PTCL patients showed significantly worse prognosis than those of the small cell group, AITL, and F-TCL (p < 0.05). CMYC + tumour cells, and combined PD-1 ligand 1 (PD-L1) + tumour cells and intense reaction of PD-L1 + non-neoplastic cells (high PD-L1 + cell group) were significantly poor prognostic factors (p < 0.05). Combinations of CMYC + or PD-1 + tumour cells and high PD-L1 + cell group indicated significantly poor prognosis (p < 0.01).
Conclusion

Large cell TFH + PTCL indicated poor prognosis in TFH + lymphomas. These data suggested that CMYC + tumour cells and intense PD-L1 + cell reaction influenced tumour cell progression in TFH + lymphomas, and PD-1 + tumour cell/intense PD-L1 + cell reactions may play a role in immune evasion.