bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Successful Publication for Systematic Review Protocol Registration: an Analysis of 397 Registered Protocols.
Authors: Minh Le Huu Nhat , Le Huu-Hoai , Tawfik Gehad Mohamed , Makram Omar Mohamed , Tieu Thuan , Tai Luu Lam Thang , Shahin Karim Mohamed , Abozaid Ali Ahmed-Fouad , Shah Jaffer , Nam Nguyen Hai , Huy Nguyen Tien 
Published: June 2021

Abstract
Background: Meta-analyses are on top of the evidence-based medicine pyramid, yet many of them are not completed after they are begun. Many factors impacting the publication of meta-analysis works have been discussed, and their association with publication likelihood has been investigated. These factors include the type of systematic review, journal metrics, h-index of the corresponding author, country of the corresponding author, funding sources, and duration of publication. In our current review, we aim to investigate these various factors and their impact on the likelihood of publication. A comprehensive review of 397 registered protocols retrieved from five databases was performed to investigate the different factors that might affect the likelihood of publication. These factors include the type of systematic review, journal metrics, h-index of the corresponding author, country of the corresponding author, funding sources, and duration of publication.Results: We found that corresponding authors in developed countries and English-speaking countries had higher likelihoods of publication: 206/320 (p=0.018) and 158/236 (p=0.006), respectively. Our models of multivariable logistic regression analysis revealed that two main factors impact the publication outcome: updated protocol status of the published review paper (OR: 1.7, 95% CI: 1.0-2.8, p=0.037) and external funding (OR: 2.1, 95% CI: 1.2-3.8, p=0.01). However, corresponding authors’ location in developed countries (OR: 1.7, 95% CI: 0.8-3.4, p=0.139) and English-speaking countries (OR: 1.5, 95% CI: 0.9-2.6, p=0.1) were insignificant determinants.Conclusion: Meta-analyses continue to be on top of the evidence hierarchy, rendering them the key to informed clinical decision-making. Therefore, more attention should be paid to the methodological quality of this type of publication.
In vitro Assessment of Intra-operative and Post-operative Environment in Reducing Bladder Cancer Recurrence
Authors: TSE Ryan Tsz-Hei , ZHAO Hongda , WONG Christine Yim-Ping , KONG Angel Wing-Yan , CHAN Ronald Cheong-Kin , TO Ka-Fai , NG Chi-Fai , TEOH Jeremy Yuen-Chun 
Published: June 2021

Abstract
Urinary bladder cancer is a common cancer worldwide. Currently, the modality of treating and monitoring bladder cancer is wide. Nonetheless, the high recurrence rate of non-muscle-invasive bladder cancer after surgical resection is still unsatisfactory. Hereby, our study demonstrated whether the intra-operative and post-operative environments will affect bladder cancer recurrence utilizing in vitro cell line model. Bladder cancer cell lines were submerged in four different irrigating fluids for assessing their tumorigenic properties. Our results showed that sterile water performed the best in terms of the magnitude of cytotoxicity to cell lines. Besides, we also investigated cytotoxic effects of the four irrigating agents as well as mitomycin C (MMC) in normothermic and hyperthermic conditions. We observed that sterile water and MMC had an increased cytotoxic effects to bladder cancer cell lines in hyperthermic conditions. Altogether, our results could be translated into clinical practice in the future by manipulating the intra-operative and post-operative conditions in order to lower the chance of residual cancer cell reimplant onto the bladder, which in turns, reducing the recurrence rate of bladder cancers.
A Window into the Breeding Ecology and Molt of the Eastern Black Rail (Laterallus jamaicensis jamaicensis)
Authors: Hand Christine E. , Gabel Wray , DiPetto Gabriella R. , Bonafilia Rachel E. , Znidersic Elizabeth 
Published: June 2021

Abstract
Knowledge of the ecology and behavior of the Eastern Black Rail (Laterallus jamaicensis jamaicensis) has remained nearly as elusive as the rail itself. Camera trapping methods facilitated the first study of breeding phenology and chick development (n = 33 broods), flightless molt phenology and duration (n = 10 adults in molt), and courtship and brood rearing behaviors. In addition, behavioral observations combined with phenology data provided evidence of pairs raising two or more broods during a breeding season. Conservation and management efforts for the Eastern Black Rail should take into consideration periods of vulnerability such as incubation, brood rearing and flightless molt, which coincide with increasingly severe and frequent coastal flooding events and hurricanes. To effectively develop conservation strategies to ensure the persistence of the Eastern Black Rail, it is necessary to understand factors key to the fecundity and survival of the subspecies.
Most natural-forming calcites precipitate at isotopic equilibrium
Authors: jie Yuan 
Published: June 2021

Abstract
Based on thermodynamic equilibrium isotope fractionation theory, this letter reasonably understands the clumping 13C-18O (Δ47 ), as well as carbon and oxygen isotope fractionation in calcites with extremely slow-growing rates from Devils Hole and Laghetto Basso (Corchia Cave) at atomic level with solid physical precipitation models and quantum-mechanical backgrounds. It is found that most calcites in nature precipitate in at equilibrium.
Genetic Stability of Aedes aegypti Populations following Invasion by wMel Wolbachia
Authors: Lau Meng-Jia , Schmidt Tom , Yang Qiong , Chung Jessica , Sankey Lucien , Ross Perran A. , Hoffmann Ary A. 
Published: June 2021

Abstract
BackgroundWolbachia wMel is the most used strain in mosquito rear and release strategies that aim to inhibit the transmission of arboviruses such as dengue, Zika, Chikungunya and yellow fever. However, the long-term establishment of wMel in natural populations of the dengue mosquito Aedes aegypti raises concerns that interactions between Wolbachia wMel and Ae. aegypti may lead to changes in the host genome, which could affect useful attributes of Wolbachia that allow it to invade and suppress disease transmission. ResultsWe applied an evolve-and-resequence approach to study genome-wide genetic changes in Ae. aegypti from the Cairns region, Australia, where Wolbachia wMel was first introduced more than 10 years ago. Mosquito samples were collected at three different time points in Gordonvale, Australia, covering the phase before (2010) and after (2013 and 2018) Wolbachia releases. An additional three locations where Wolbachia replacement happened at different times across the last decade were also sampled in 2018. We found that the genomes of mosquito populations mostly remained stable after Wolbachia release, with population differences tending to reflect the geographic location of the populations rather than Wolbachia infection status. However, outlier analysis suggests that Wolbachia may have had an influence on some genes related to immune response, development, recognition and behavior. ConclusionsAe. aegypti populations remained geographically distinct after Wolbachia wMel releases in North Australia despite their Wolbachia infection status. At some specific genomic loci, we found signs of selection associated with Wolbachia, suggesting potential evolutionary impacts can happen in the future and further monitoring is warranted.
De Novo Hepatocellular Carcinoma in Hepatitis C-Related Cirrhosis: Are Advanced Glycation end Products a Key Driver?
Authors: Abdel-Razik Ahmed , Shabana Walaa , Nakib Ahmed Mohamed El , Abdelsalam Mostafa , Abdelwahab Ahmed , Hasan Ahmad S. , Elzehery Rasha , Elhelaly Rania , Fathy Aya Ahmed , Mostafa Sally Abdallah , Yassen Ahmed H. 
Published: June 2021

Abstract
Background: The advanced glycation end products (AGEs) have been implicated in different diseases' pathogenesis, but their role in hepatocellular carcinoma (HCC) is still a matter of debate. This study aims to investigate the association of AGEs with HCC development in patients with cirrhosis. Methods: Only 153 of the 181 non-diabetic patients with cirrhosis were consecutively involved in this pilot cohort prospective study, along with 34 healthy control participants. Demographic characteristics, biochemical parameters, clinical data, and AGEs levels in all subjects at the starting point and every year after that for two years were assessed. Multivariable Cox regression analysis was used to settle variables that could predict HCC development within this period. Results: HCC developed in 13 (8.5%) patients. Univariate Cox regression analysis reported that age (P=0.043), treatment with direct-acting antivirals (DAAs) (P=0.021), and AGEs levels (P=0.04) were related to HCC development. After adjusting multiple confounders, the multivariable Cox regression model has revealed that treatment with DAAs and AGEs were the powerful parameters related to the HCC occurrence (all P<0.05). AGEs at a cutoff value of more than 79.6 ng/ml had 100% sensitivity, 96.4% specificity, and 0.999 area under the curve (all P<0.001), using the receiver operating characteristic curve, for prediction of HCC development. Conclusion: This work suggests that AGEs are associated with an increased incidence of HCC, particularly in cirrhosis, which is encouraging in decreasing the risk of HCC in these patients.
Characterization of Activated Carbon Prepared From the Nucleus of Ziziphus Lotus (NBEG): Isothermal Study and Kinetics of Adsorption of Methylene Blue
Authors: Touzani Ibrahim , FIKRI-BENBRAHIM Kawtar , Ahlafi Hammou , Ihssane Bouchaib , Boudouch Otmane 
Published: June 2021

Abstract
Ziziphus lotus (Nbeg) is very common in Morocco where it occupies various ecosystems and presents different interests; however it remains devalued and knows recent deterioration due to the human pressure through clearing, wood collection, irrational cuts’ exploitation and overgrazing. This study aims to prepare activated carbon from the cores of this interesting biomaterial, for the first time to the best of our knowledge, according to a manufacturing process based on its chemical and thermal activation. The cores of Ziziphus lotus (Nbeg) were chemically activated by sulfuric acid (H2SO4, 98%) for 24h with a mass contribution (1:1), and then carbonized at a temperature of 500 °C for 2 hours. The obtained activated carbon was characterized by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and specific surface measurement. These characterization results showed an important porosity and a surface structure having acid groups and carboxylic functions. The adsorption of methylene blue (MB) was evaluated, by Langmuir and Freundlich models examination, in order to explain the adsorption efficiency in a systematic and scientific way. Also pseudo-first order and pseudo-second order kinetic models were used to identify the possible mechanisms of this adsorption process. The results showed that the MB adsorption process on activated carbon follows the Langmuir model and that the adsorption kinetic is best represented by kinetics data of the pseudo-second order model. Therefore, Z. lotus can be used as a low-cost available material to prepare a high quality activated carbon having a promising potential in the wastewater treatment.
Diattenuation and Retardance Signature of Plasmonic Gold Nanorods in Turbid Media Revealed by Mueller Matrix Polarimetry
Authors: Ray Subir Kumar , Ghosh Nirmalya , Vitkin Alex 
Published: June 2021

Abstract
Plasmonic gold nanorods (GNRs) are finding increasing use in biomedicine due to their unique electromagnetic properties, optical contrast enhancement and biocompatibility; they also show promise as polarization contrast agents. However, quantification of their polarization-enhancing properties within heterogeneous turbid media remains challenging. We report on polarization response in controlled tissue phantoms consisting of dielectric microsphere scatterers with varying admixtures of GRNs. Experimental Mueller matrix measurements and polarization sensitive Monte-Carlo simulations show excellent agreement. Despite the random 3D orientation and distribution of GNRs and strong multiple scattering background, significant linear diattenuation and retardance were observed that are exclusive characteristics of the GNRs, suggesting their potential as contrast agents for polarimetric imaging of biological tissue
Substance use and psychiatric disorders in patients referred to consultation-liaison psychiatry within a regional general hospital
Authors: Tucker Murray , Hill Harry , Nicholson Emma , Moylan Steven 
Published: June 2021

Abstract
Little is known about clinically important differences between patients depending on the number of comorbid psychiatric disorders, or the presence or absence of a substance use disorder (SUD) comorbidity. This study investigated for differences in psychosocial disadvantage, psychiatric disorders, and health service amongst 194 general hospital patients referred to consultation-liaison psychiatry (CLP) with no psychiatric diagnosis, single psychiatric diagnosis, multiple (non-SUD) psychiatric diagnoses, or psychiatric diagnosis plus SUD comorbidity. The results showed that SUDs were the commonest diagnostic category (34%). The SUD comorbidity group had more disadvantaged housing, were prescribed most psychoactive medications, and 20% prematurely self-discharged against medical advice. Increased SUDs were associated with reduced length of stay, men, younger age, increased investigations, and reduced private health insurance subscription. Patients with SUD comorbidity versus multiple psychiatric diagnosis had reduced odds of Adjustment Disorder, Somatic Symptom Disorder, and Insomnia Disorder. Post Traumatic Stress Disorder was the strongest predictor of multiple SUDs, followed by Cluster B personality disorders. In conclusion, SUDs have become a leading clinical focus for CLP. The presence or absence of SUDs amongst patients with multiple psychiatric disorders has important clinical implications for engagement, diagnosis, prescribing, and outpatient follow-up.
Appropriateness of using vitamin K for the correction of INR elevation secondary to hepatic disease in critically ill patients: An Observational Study
Authors: Sulaiman Khalid Al , Mutairi Mashael Al , Harbi Omar Al , Duraihim Alanoud Al , Aldosary Sara , Khalil Haifa Al , Shaya Abdulrahman Al , Harbi Shmeylan Al , Marshdi Nouf Al , Aamer Kholoud Al , Vishwakarma Ramesh , Katheri Abdulmalik Al , Bekairy Abdulkareem M. Al 
Published: June 2021

Abstract
Background Hepatic diseases have been associated with an increased risk of coagulopathy and increased odds of secondary thrombosis and bleeding. Using vitamin K for correction of coagulopathy in critically ill patients is controversial with limited evidence. Objective To evaluate the efficacy as well as safety of vitamin K in correction of international normalized ratio (INR) elevation secondary to liver disease in critically ill patients. Setting Tertiary teaching hospital in Saudi Arabia. Method A retrospective case-control study of adult ICU patients with coagulopathy secondary to liver disease. A total of 98 patients were included in the study. Patients were divided into two groups based on vitamin K administration to correct INR elevation. differences. The propensity score was generated based on disease severity scores to adjust group. Main outcomes The primary outcome was to evaluate the association between vitamin K administration and the incidence of new bleeding events in critically ill patients with INR elevation secondary to liver disease. Secondary outcomes were to evaluate the incidence of a new thrombotic event and the degree of INR correction with vitamin K. Results Forty-seven patients (48%) received vitamin K during the study period. The incidence of the new bleeding event was not statistically different between groups (OR 2.4, 95% CI 0.28-21.67, P=0.42). Delta of INR reduction was observed with a median of 0.63 when the first dose is given (p-value: <.0001). However, other subsequent doses of vitamin K were not statistically significant. Conclusion Using vitamin K for INR correction in critically ill patients with coagulopathy secondary to liver disease was not associated with a lower incidence of new bleeding events. Vitamin K was efficient in reducing INR level at the first dose, other subsequent doses were not.Impacts on practice: Routine use of vitamin K to correct PT/INR in critically ill patients with liver disease may need be re-evaluated.If the initial dose of vitamin K does not reverse INR elevation, subsequent doses may not have any effect.Using vitamin K to correct INR was not associated with a lower incidence of new bleeding events nor RBCs/Platelets transfusion than patients who did not receive it.
Alzheimer's Disease Early Detection Using Machine Learning Techniques
Authors: Alroobaea Roobaea , Mechti Seifeddine , Haoues Mariem , Rubaiee Saeed , Ahmed Anas , Andejany Murad , Bragazzi Nicola Luigi , Sharma Dilip Kumar , Kolla Bhanu Prakash , Sengan Sudhakar 
Published: June 2021

Abstract
Alzheimer's is the main reason for dementia, that affects frequently older adults. This disease is costly especially, in terms of treatment. In addition, Alzheimer's is one of the deaths causes in the old-age citizens. Early Alzheimer's detection helps medical staffs in this disease diagnosis, which will certainly decrease the risk of death. This made the early Alzheimer's disease detection a crucial problem in the healthcare industry. The objective of this research study is to introduce a computer-aided diagnosis system for Alzheimer's disease detection using machine learning techniques. We employed data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Open Access Series of Imaging Studies (OASIS) brain datasets. Common supervised machine learning techniques have been applied for automatic Alzheimer’s disease detection such as: logistic regression, support vector machine, random forest, linear discriminant analysis, etc. The best accuracy values provided by the machine learning classifiers are 99.43% and 99.10% given by respectively, logistic regression and support vector machine using ADNI dataset, whereas for the OASIS dataset, we obtained 84.33% and 83.92% given by respectively logistic regression and random forest.
Biogenic Zinc Oxide Nano-structures Differentiation under Musical Sounds
Authors: Bakir Aya , Hamimed Selma , Landoulsi Ahmed , Chatti Abdelwaheb 
Published: June 2021

Abstract
A new emerging and green approach was used to synthesis nanomaterials. In the present study, we report the use of Yarrowia lipolytica supernatant in the synthesis of zinc oxide nanoparticles (ZnO NPs). During the synthesis, the reactional medium was subjected to different musical sounds (MSs) such as Quran sound, Tunisian music, and Flamingo. The obtained nanoparticles were analysed using UV–vis spectroscopy, which showed a peak near to 258 nm characteristic of ZnO NPs. The Fourier transform infrared spectrum was established to identify the functional groups that recorded absorption bands at 564 and 574 cm− 1 confirming the presence of ZnO NPs. While, X-ray diffraction revealed the high purity crystalline ZnO NPs and indicated the effectiveness of MSs on the crystal size by having the smallest size on Quran sound (20.9 nm). Moreover, ZnO NPs morphology was affected by the MSs that varied from spherical agglomerated to nanotubular shapes. These results reveal the successful use of MSs in the synthesis of smaller and controlled nanoparticles.
Production of biodegradable sodium caseinate film containing titanium oxide nanoparticles and grape seed essence and investigation of physicochemical properties
Authors: Yorghanlu Roghiye Ashrafi , Hemmati Haleh , Pirsa Sajad , Makhani Arezu 
Published: June 2021

Abstract
In this study sodium caseinate film was produced and the effect of titanium oxide nanoparticles and grape seed essence as factors that enhances film properties was investigated. For this purpose, nanocomposite films based on sodium caseinate were modified with different levels of nanoparticles of 0 to 1.5 % and grape seed essence at levels of 0 to 500 ppm based on the central composite experimental design (CCD). The effects of these variables on physical/mechanical properties, water vapor permeability and antioxidant properties were investigated. The morphology and chemical structure of different films were evaluated by SEM and FTIR techniques. The results showed that the addition of titanium oxide nanoparticles has improved the mechanical properties of the films. In this regard, films prepared from 1.5% and 500 ppm nanoparticles have the highest tensile strength. The results of scanning electron microscopy test showed that the addition of nanoparticles led to the indirect penetration of water, which reduced the permeability of the films to water vapor to 4.89 kg/m. The addition of grape seed essence caused the antioxidant effects of the produced films, so that the films containing 250 ppm showed antioxidant activity of 86.74%. Overall, the results showed that the addition of nanoparticles and grape seed essence had positive effects on the physical and chemical properties of sodium caseinate.
Computer vision application in tracking grooming behaviour in arthropods
Authors: Munshi Chayan , Sadhu Arnab , Chatterjee Subhendu Kumar , Bhattacharya Shelley 
Published: June 2021

Abstract
Computer vision application is a broad-spectrum sophisticated technique of high accuracy, which can be used efficiently to detect objects from a video footage. The principle of feature detection is being implemented through this technique for the recognition of desired behavioural patterns. Our results demonstrate a competent function of SURF (Speeded Up Robust Features), a computer vision algorithm in assessing animal behaviour from a recorded video. In the present study, we have applied this algorithm for accurate quantification of grooming behaviour in aquatic arthropods, using a semi-transparent freshwater prawn, Macrobrachium lamarrei as a model organism. Grooming behaviour is considered as an index of neuronal stress in several animals. We predict the effective application of this method in the area of behavioural ecology and neuroethological research in diverse group of animals.
Trend analyses suggest gender-focused, peer-aware, and parent-targeted interventions could reduce teenage e-cigarette use
Authors: Hanafin Joan , Sunday Salome , Clancy Luke 
Published: June 2021

Abstract
E-cigarette ever-use and current-use among teenagers has been increasing worldwide, including in Ireland. Boys are widely observed to have increased prevalence compared with girls.We use data from two waves of the European School Survey Project on Alcohol and other Drugs (ESPAD) in Ireland and focus on gender and teenage e-cigarette use. We examine changes in ever and current-use among 16-year-olds (n = 3,421) between 2015 and 2019. We use multivariable logistic regression analyses to explore relative and gendered effects of covariates on teenage e-cigarette use.E-cigarette ever-use increased from 23–39% and current-use from 10–18%, (in 2015 vs 2019, respectively). The rate of increase in ever-use is significantly greater for girls AOR 2.67 (C.I. 2.02, 3.54) vs 2.04 (C.I. 1.55, 2.68) for boys. Smoking and e-cigarette use are linked but never-smokers who try e-cigarettes have risen from 33–67%. Peer smoking is also significantly associated with e-cigarette ever- and current-use, particularly for boys if “Most/All friends smoke” AOR 5.90 (C.I. 3.31, 10.52) vs 3.50 (C.I. 1.79, 6.84) for girls. Less parental monitoring is associated with greater e-cigarette use, for boys AOR 5.50 (C.I. 2.85, 10.61) vs AOR 5.31 (C.I. 3.01, 9.37) for girls.Boys currently have a higher prevalence of e-cigarette use but girls are increasingly at risk. Targeting by industry through advertising, gaming and social media may contribute to use. Peer influences and parental monitoring are significant risk factors for use and provide a mechanism for intervention to prevent an increasing risk of nicotine addiction.