bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sedentary Profiles: A New Perspective on Accumulation Patterns in Sedentary Behavior
Authors: HIBBING PAUL R. , BELLETTIERE JOHN , CARLSON JORDAN A. 
Published: November 2021

ABSTRACT
The health effects of sedentary behavior (SB) may be moderated by SB accumulation patterns (e.g., in prolonged bouts). These patterns are challenging to assess thoroughly and interpretably.

Purpose
The purpose of this study is to introduce SB profiles (i.e., groups of similar SB accumulation patterns) as a new approach to pattern-focused SB research.

Methods
Data came from the National Health and Nutrition Examination Survey (2003–2006). The SB bouts were determined from hip-worn accelerometer data, and k-medoid clustering was used to define three SB profiles (interrupted, intermediate, and prolonged). These were used as the exposure in logistic regression models to examine odds ratios (OR) of having high (>20%) predicted-10-yr risk of cardiovascular disease (CVD). For comparison, the models were also fitted using standard metrics (i.e., tertiles of mean SB bout duration and daily total SB time).

Results
Those with interrupted profile (n = 1740) were typically sedentary ~32% of the time, in bouts ≤15 min. Those with intermediate profile (n = 2453) were typically sedentary ~47% of the time, in bouts ≤20 min. Those with prolonged profile (n = 1302) were typically sedentary ~61% of the time, frequently in bouts >20 min. The fully adjusted model showed that high CVD risk was more common for the intermediate (OR, 1.87) and prolonged (OR, 4.65) profiles than the interrupted profile (all P < 0.001). For standard metrics, OR ranged from 1.46 (middle tertile of daily total SB time) to 4.11 (upper tertile of mean bout duration) with all P < 0.002.

Conclusions
The SB profiles represent a promising new avenue for understanding and combating adverse SB trends. The value of the approach was highlighted by the strong associations with CVD risk.
Assessment of the physical development and metabolic status of children born to women with gestational diabetes
Authors: Deynega (Masel) A. S. , Liskina A. S. , Valieva S. A. , Nikitina I. L. 
Published: November 2021

Backgraund: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders found during pregnancy. Currently, it is relevant not only to search optimal target levels of glycemia during pregnancy, but also to study the ­effect of different glycemia levels on fetal development and further changes in glucose and lipid metabolism in children.Aims: To describe perinatal period, physical development and metabolic status of children born to women with GDM and different glucose levels during pregnancy.Materials and methods: The perinatal period features and anthropometric parameters at birth were evaluated in 300 children born to women with GDM and different levels of glycemia during pregnancy. Over the course two years, 141 children have been evaluated for physical development parameters and glucose and lipid metabolism. Fasting and postprandial glycemia was measured with glucometer for 14 days in 33 children aged 1 to 4 years.Results: The anthropometric parameters of children at birth did not differ from the parameters of the control group (p> 0.05) when during pregnancy fasting blood glucose was less than 5.1 mmol / l and 7.0 mmol / l 1 hour after a meal. The glycemia in women above this level was associated with an increase of frequency and risk of a body mass index, body mass / length ratio and head circumference “above average” in children at birth (p <0.05). With the dynamic control of anthropometric parameters up to 2 years, no differences between the comparison groups were obtained (p> 0.05). The change in metabolic parameters was represented by neonatal hypoglycemia in children of GDM group (GDM group — 23%, control group — 3.5%, p = 0.000002), the least risk of which occurred in group with the lowest fasting and postprandial glycemic values during pregnancy. Fasting glucose, and insulin levels, НOMA index, triglycerides and cholesterol, as well as monitoring fasting and postprandial glycemia for 14 days, were obtained no significant differences between the comparison groups of children (p> 0.05).Conclusions: The lowest risks of neonatal hypoglycemia and anthropometric deviations at birth were associated with the lowest glycemia levels during pregnancy, which correspond to the criteria of the Russian clinical guidelines.
Features of heart failure with preserved ejection fraction (HFpEF) in diabetic patients with resistant hypertension
Authors: Manukyan M. A. , Falkovskaya A. Y. , Mordovin V. F. , Ryabova T. R. , Zyubanova I. V. , Gusakova A. M. , Suslova T. E. 
Published: November 2021

BACKGROUND: It is expected that a steady increase in the incidence of diabetes and resistant hypertension (RHTN), along with an increase in life expectancy, will lead to a noticeable increase in the proportion of patients with heart failure with preserved ejection fraction (HFpEF). At the same time, data on the frequency of HFpEF in a selective group of patients with RHTN in combination with diabetes are still lacking, and the pathophysiological and molecular mechanisms of its formation have not been yet studied sufficiently.AIM: To assess the features of the development HFpEF in diabetic and non-diabetic patients with RHTN, as well as to determine the factors associated with HFpEF.MATERIALS AND METHODS: In the study were included 36 patients with RHTN and type 2 diabetes mellitus (DM) (mean age 61.4 ± 6.4 years, 14 men) and 33 patients with RHTN without diabetes, matched by sex, age and level of systolic blood pressure (BP). All patients underwent baseline office and 24-hour BP measurement, echocardiography with assess diastolic function, lab tests (basal glycemia, HbA1c, creatinine, aldosterone, TNF-alpha, hsCRP, brain naturetic peptide, metalloproteinases of types 2, 9 (MMP-2, MMP-9) and tissue inhibitor of MMP type 1 (TIMP-1)). HFpEF was diagnosed according to the 2019 AHA/ESC guidelines.RESULTS: The frequency of HFpEF was significantly higher in patients with RHTN with DM than those without DM (89% and 70%, respectively, p=0.045). This difference was due to a higher frequency of such major functional criterion of HFpEF as E/e’≥15 (p=0.042), as well as a tendency towards a higher frequency of an increase in left atrial volumes (p=0.081) and an increase in BNP (p=0.110). Despite the comparable frequency of diastolic dysfunction in patients with and without diabetes (100% and 97%, respectively), disturbance of the transmitral blood flow in patients with DM were more pronounced than in those without diabetes. Deterioration of transmitral blood flow and pseudo-normalization of diastolic function in diabetic patients with RHTN have relationship not only with signs of carbohydrate metabolism disturbance, but also with level of pulse blood pressure, TNF-alfa, TIMP-1 and TIMP-1 / MMP-2 ratio, which, along with the incidence of atherosclerosis, were higher in patients with DM than in those without diabetes.CONCLUSIONS: Thus, HFpEF occurs in the majority of diabetic patients with RHTN. The frequency of HFpEF in patients with DN is significantly higher than in patients without it, which is associated with more pronounced impairments of diastolic function. The progressive development of diastolic dysfunction in patients with diabetes mellitus is associated not only with metabolic disorders, but also with increased activity of chronic subclinical inflammation, profibrotic state and high severity of vascular changes.
Annual biological variation and personalized reference intervals of clinical chemistry and hematology analytes
Authors: Wang Shuo , Zhao Min , Su Zihan , Mu Runqing 
Published: November 2021

Abstract

Objectives
A large number of people undergo annual health checkup but accurate laboratory criterion for evaluating their health status is limited. The present study determined annual biological variation (BV) and derived parameters of common laboratory analytes in order to accurately evaluate the test results of the annual healthcare population.

Methods
A total of 43 healthy individuals who had regular healthcare once a year for six consecutive years, were enrolled using physical, electrocardiogram, ultrasonography and laboratory. The annual BV data and derived parameters, such as reference change value (RCV) and index of individuality (II) were calculated and compared with weekly data. We used annual BV and homeostatic set point to calculate personalized reference intervals (RIper) which were compared with population-based reference intervals (RIpop).

Results
We have established the annual within-subject BV (CVI), RCV, II, RIper of 24 commonly used clinical chemistry and hematology analytes for healthy individuals. Among the 18 comparable measurands, CVI estimates of annual data for 11 measurands were significantly higher than the weekly data. Approximately 50% measurands of II were <0.6, the utility of their RIpop were limited. The distribution range of RIper for most measurands only copied small part of RIpop with reference range index for 8 measurands <0.5.

Conclusions
Compared with weekly BV, for annual healthcare individuals, annual BV and related parameters can provide more accurate evaluation of laboratory results. RIper based on long-term BV data is very valuable for “personalized” diagnosis on annual health assessments.
Biological variation estimates of thyroid related measurands – meta-analysis of BIVAC compliant studies
Authors: Fernández-Calle Pilar , Díaz-Garzón Jorge , Bartlett William , Sandberg Sverre , Braga Federica , Beatriz Boned , Carobene Anna , Coskun Abdurrahman , Gonzalez-Lao Elisabet , Marques Fernando , Perich Carmen , Simon Margarida , Aarsand Aasne K. 
Published: November 2021

Abstract

Objectives
Testing for thyroid disease constitutes a high proportion of the workloads of clinical laboratories worldwide. The setting of analytical performance specifications (APS) for testing methods and aiding clinical interpretation of test results requires biological variation (BV) data. A critical review of published BV studies of thyroid disease related measurands has therefore been undertaken and meta-analysis applied to deliver robust BV estimates.

Methods
A systematic literature search was conducted for BV studies of thyroid related analytes. BV data from studies compliant with the Biological Variation Data Critical Appraisal Checklist (BIVAC) were subjected to meta-analysis. Global estimates of within subject variation (CVI) enabled determination of APS (imprecision and bias), indices of individuality, and indicative estimates of reference change values.

Results
The systematic review identified 17 relevant BV studies. Only one study (EuBIVAS) achieved a BIVAC grade of A. Methodological and statistical issues were the reason for B and C scores. The meta-analysis derived CVI generally delivered lower APS for imprecision than the mean CVA of the studies included in this systematic review.

Conclusions
Systematic review and meta-analysis of studies of BV of thyroid disease biomarkers have enabled delivery of well characterized estimates of BV for some, but not all measurands. The newly derived APS for imprecision for both free thyroxine and triiodothyronine may be considered challenging. The high degree of individuality identified for thyroid related measurands reinforces the importance of RCVs. Generation of BV data applicable to multiple scenarios may require definition using “big data” instead of the demanding experimental approach.
Trichostatin A sensitizes hepatoma cells to Taxol more than 5-Aza-dC and dexamethasone
Authors: Donia Thoria , Khedr Sherien , Salim Elsayed I. , Hessien Mohamed 
Published: November 2021

Abstract

Objectives
This work was designed to compare the sensitizing effects of epigenetic modifiers on cancer cells vs. that of glucocorticoids. Also, to evaluate their effects on genes involved in epigenetic changes and drug metabolism.

Methods
Hepatoma cells (HepG2) were treated with the anticancer drug (Taxol), with a histone deacetylase inhibitor (Trichostatin A [TSA]), DNA methyltransferase inhibitor (5-Aza-dC) or dexamethasone (DEX). Cytotoxicity was assessed by MTT assay and the apoptosis was determined by Annexin V-FITC. The expression levels of HDAC1, HDAC3, Dnmt1, Dnmt3α, CYP1A2, CYP3A4, CYP2B6, CYP2C19 and CYP2D6 were monitored by qRT-PCR.

Results
TSA, synergistically enhanced cells sensitivity with the anticancer effect of Taxol more than 5-Aza-dC and DEX. This was evidenced by the relative decrease in IC50 in cells cotreated with Taxol + TSA, Taxol + 5-Aza-dC or Taxol + DEX. Apoptosis was induced in 51.2, 16.9 and 41.3% of cells, respectively. In presence of Taxol, TSA induced four-fold increase in the expression of HDAC1 and downregulated Dnmt1&3α genes. CYP2D6 demonstrated progressive expression (up to 28-fold) with the increasing number of drugs. Moreover, the isoform overexpressed in cells treated with TSA + Taxol > DEX + Taxol > 5-Aza-dC + Taxol (6.4, 4.6 and 2.99, respectively). The investigated genes were clustered in two distinct subsets, where no coregulation was observed between HDAC1 and HDAC3. However, tight pairwise correlation-based cluster was seen between (CYP3A4/Dnmt3α and CYP2D6/CYP2C19).

Conclusions
The data reflects the sensitizing effect of acetylation modification by TSA on the responsiveness of hepatoma cells to anticancer therapy. The effect of histone deacetylase inhibition was more than hypomethylation and glucocorticoid effects. TSA exerts its role through its modulatory role on epigenetics and drugs metabolizing genes. Other modifiers (5-Aza-dC and DEX), however may adopt different mechanisms.
A guide to value of information methods for prioritising research in health impact modelling
Authors: Jackson Christopher , Johnson Robert , de Nazelle Audrey , Goel Rahul , de Sá Thiago Hérick , Tainio Marko , Woodcock James 
Published: November 2021

AbstractHealth impact simulation models are used to predict how a proposed policy or scenario will affect population health outcomes. These models represent the typically-complex systems that describe how the scenarios affect exposures to risk factors for disease or injury (e.g. air pollution or physical inactivity), and how these risk factors are related to measures of population health (e.g. expected survival). These models are informed by multiple sources of data, and are subject to multiple sources of uncertainty. We want to describe which sources of uncertainty contribute most to uncertainty about the estimate or decision arising from the model. Furthermore, we want to decide where further research should be focused to obtain further data to reduce this uncertainty, and what form that research might take. This article presents a tutorial in the use of Value of Information methods for uncertainty analysis and research prioritisation in health impact simulation models. These methods are based on Bayesian decision-theoretic principles, and quantify the expected benefits from further information of different kinds. Theexpected value of partial perfect informationabout a parameter measures sensitivity of a decision or estimate to uncertainty about that parameter. Theexpected value of sample informationrepresents the expected benefit from a specific proposed study to get better information about the parameter. The methods are applicable both to situations where the model is used to make a decision between alternative policies, and situations where the model is simply used to estimate a quantity (such as expected gains in survival under a scenario). This paper explains how to calculate and interpret the expected value of information in the context of a simple model describing the health impacts of air pollution from motorised transport. We provide a general-purpose R package and full code to reproduce the example analyses.
Combining good dispersion with tailored charge trapping in nanodielectrics by hybrid functionalization of silica
Authors: He Xiaozhen , Rytöluoto Ilkka , Anyszka Rafal , Mahtabani Amirhossein , Niittymäki Minna , Saarimäki Eetta , Mazel Christelle , Perego Gabriele , Lahti Kari , Paajanen Mika , Dierkes Wilma , Blume Anke 
Published: November 2021

Abstract
Fumed silica-filled polypropylene (PP)-based nanodielectrics were studied in this work. To not only improve the dispersion of the silica but also introduce deep charge traps into the polymeric matrix, five types of modified silicas were manufactured with different surface modifications. The modified silica surfaces comprise an inner and a surface layer. The inner layer contains a polar urethane group for tailoring the charge trap properties of the PP/propylene–ethylene copolymer nanocomposites, whereas the surface layer consists of hydrocarbons (ethyl-, tert-butyl-, cyclopentyl-, phenyl-, or naphthalenyl moieties) in order to gain a good dispersion of the silica in the unpolar polymer blend. Scanning electron microscopic pictures proved that these tailored silicas show a much better dispersion than the unmodified one. Thermally stimulated depolarization current measurements revealed the ability of the silica to introduce deep charge traps with low trap density. The trap depth distribution depends on the type of the unpolar surface layer consisting of the different hydrocarbons. Among these five differently modified silicas, the introduction of the one with a surface layer consisting of tert-butyl moieties resulted in the lowest charge injection and the lowest charge current in the nanocomposite, proving good dielectric performance. Additionally, this silica exhibits good dispersion in the polymeric matrix, indicating a promising performance for nanodielectric application.
Experimental investigation on the effect of accelerated ageing conditions on the pull-out capacity of compressed wood and hardwood dowel type fasteners
Authors: Mehra Sameer , Harte Annette M. , Sotayo Adeayo , Guan Zhongwei , O’Ceallaigh Conan 
Published: November 2021

Abstract
The widespread use of adhesives in timber construction has negative implications for the end-of-life disposal or re-use of the structural timber components. To promote the circular bioeconomy, it is preferable to substitute adhesives with more sustainable alternatives such as wood-based connectors. Today, robotic fabrication technologies facilitate the development of dowel-laminated timber (DLT) products whereby hardwood dowels are used to connect timber laminates as a substitute to adhesives. In recent years, thermo-mechanical densification of wood has resulted in significant improvements in the mechanical performance of the wood. This modified product often termed compressed wood (CW) has a shape-recovery effect which may be beneficial for the development of DLT products and timber-timber connections with improved friction fit with time. To test the hypothesis, accelerated ageing tests were carried out on CW-timber and hardwood-timber dowel type connections subjected to variable climate conditions. Finally, the capacity of the connections or friction fit was assessed using pull-out tests. Results show that the shape-recovery effect leads to the continuous expansion of the CW dowels and facilitates a friction fit with the timber substrate yielding higher pull-out loads when compared to hardwood dowels.
Language ideologies and social positioning: the restoration of a “much needed bridge”
Authors: Spitzmüller Jürgen , Busch Brigitta , Flubacher Mi-Cha 
Published: November 2021

AbstractIn recent years, the intersections between, or entanglements of, local action and translocal patterns gained renewed interest in sociolinguistics. Received distinctions such asmicro/macroorpractice/structurehave been challenged and confronted with more granular concepts such associolinguistic scales. Consequently, established disciplinary orientations such asmicro/macroorqualitative/quantitative sociolinguisticshave also been questioned: rather than one of two options, sociolinguistics is now supposed to embrace “complexity”. This fundamental discussion also centrally concerns research into language ideologies. While it has always been acknowledged that language ideologies frame and shape, or manifest in, local action, they have long been construed as a translocal social order, a “macro phenomenon”. In the wake of the general discussion outlined above, however, this has been challenged. Language ideologies are now increasingly located at the intersection of structure and practice, construed as structurating practices and as dynamic, scalar phenomena that emerge from, and are subjected to, ongoing local processes of social positioning and indexical enregisterment (which they reversely frame). This special issue takes up the discussion and asks where we can get to with such a complex notion of language ideologies and/as social positioning, how far we have come already, and which obstacles lie ahead. The authors address these questions from different perspectives. This introduction sets the scene, recapitulates the discussion and state of the art, and provides an outline of the issue.
Indexical borders: the sociolinguistic scales of the shibboleth
Authors: Busch Brigitta , Spitzmüller Jürgen 
Published: November 2021

Abstract
This paper engages with the notion of the shibboleth, an indexically loaded, usually referentially indifferent set of (ideologically constructed) minimal pairs that is used in order to mark and perform social differentiation. We argue that the shibboleth is to be considered an interpretive (metapragmatic) phenomenon that operates on different sociolinguistic scales, notably the discursive scale (ideologies of communication), the performative scale (performance and metapragmatic stance-taking), and the subjective scale (lived experience). We propose a scalar metapragmatic theory of the shibboleth as an “indexical border” that takes into account how shibboleths emerge (are enregistered) and how they depend on contextualisation (or the indexical field). As a case in point, we present analyses of biographical construals of sociolinguistic displacement in the context of remigration from German-speaking countries to Bosnia and Herzegovina. Specifically, we focus on construals of displacement that are connected with (mis-)performances of phonologically rather subtle but indexically highly salient Bosnian/Croatian/Serbian affricate shibboleths (<č/dž> and <ć/đ>).
Figures of personhood: time, space, and affect as heuristics for metapragmatic analysis
Authors: Park Joseph Sung-Yul 
Published: November 2021

Abstract

Figure of personhood, or set of indexicals that are linked with a performable person type, occupies a key role in contemporary metapragmatic analysis. But how can the concept be operationalized so that it can be used to link metapragmatic analysis to critical investigation of the political processes underlying society? In this paper, I suggest that focusing on how figures of personhood in metapragmatic discourse are organized along dimensions of time, space, and affect can serve as valuable heuristics for a critically oriented metapragmatic analysis, as it is those dimensions that highlight the material and political groundedness of figures of personhood. This point is then demonstrated through three sample cases: representations of Koreans as incompetent speakers of English in a commercial advertisement, middle-class Filipino youths’ self-positioning through construction of an undesirable elite figure, and valorization of neoliberal future-readiness in a promotional video for a Singaporean university’s student career center.