bluuebunny/crossref_metadata_2025_split huggingface dataset:
WHAT IS GENERATIVE IN GENERATIVE DESIGN TOOLS? UNCOVERING TOPOLOGICAL GENERATIVITY WITH A C-K MODEL OF EVOLUTIONARY ALGORITHMS
Authors: Hatchuel Armand , Le Masson Pascal , Thomas Maxime , Weil Benoit 
Published: August 2021

AbstractGenerative design (GD) algorithms is a fast growing field. From the point of view of Design Science, this fast growth leads to wonder what exactly is 'generated' by GD algorithms and how? In the last decades, advances in design theory enabled to establish conditions and operators that characterize design generativity. Thus, it is now possible to study GD algorithms with the lenses of Design Science in order to reach a deeper and unified understanding of their generative techniques, their differences and, if possible, find new paths for improving their generativity.In this paper, first, we rely on C-K ttheory to build a canonical model of GD, based independent of the field of application of the algorithm. This model shows that GD is generative if and only if it builds, not one single artefact, but a “topology of artefacts” that allows for design constructability, covering strategies, and functional comparability of designs. Second, we use the canonical model to compare four well documented and most advanced types of GD algorithms. From these cases, it appears that generating a topology enables the analyses of interdependences and the design of resilience.
WHAT IS SUCCESSFUL PROTOTYPING? INSIGHTS FROM NOVICE DESIGNERS’ SELF-EVALUATION OF PROTOTYPING SUCCESS
Authors: Hansen Camilla Arndt , Martins Pacheco Nuno Miguel , Özkil Ali Gürcan , Zimmermann Markus 
Published: August 2021

AbstractPrototyping is essential for fuzzy front-end product development. The prototyping process answers questions about critical assumptions and supports design decisions, but it is often unstructured and context-dependent. Previously, we showed how to guide novice designers in early development stages with prototyping milestones. Here, we studied the prototyping success perceived by novice design teams. This was done in two steps: (1) teams were asked to assign each prototype to a milestone, a specific purpose, a fidelity level, and a human-centered design lens, and then evaluate the success using a predefined set of criteria. (2) Teams were interviewed about the success of the prototyping process, this time using self-chosen criteria. Results related to (1) show that teams perceived prototyping activities with respect to desirability and problem validation significantly less successful than prototyping activities towards feasibility and solution validation. Results related to (2) show that teams mostly chose success criteria related to how well prototypes supported communication, decision making, learning, and tangibility. This insight may be used to give priorities to further improvement of methods and guidance in these areas.
ZOOMING IN ON PRODUCT-SERVICE SYSTEM ECODESIGNING: A NOVEL ANALYSIS APPROACH AND APPLICATION TO A CASE INVOLVING EXPERIENCED PRACTITIONERS
Authors: Neramballi Abhijna , Sakao Tomohiko 
Published: August 2021

AbstractIn this article, we introduce a protocol analysis-based approach to analyze the cognitive characteristics of conceptual ecodesigning of product-service systems (PSSs). We initially present a novel and generic model to represent the lifecycle stages of solutions offered by industry and we contextualize it to PSS based offerings. Based on this representation of the PSS lifecycle stages and that of its architecture, we propose a multi-level coding scheme and a protocol analysis-based approach to analyze the distribution of designers' cognitive effort on the following three dimensions: i) different lifecycle stages, ii) different aspects of PSS architecture and iii) ecodesign activities and environmental issues. We applied this approach to analyze a conceptual PSS ecodesign case, performed in a laboratory setting by a pair of experienced practitioners. The results clearly indicate the evidence of quantitative differences in the distribution of the designers' cognitive effort on the different dimensions of PSS ecodesigning and thus, confirms the applicability and utility of the proposed approach.
CIRCULAR ECONOMY AND DIGITAL TECHNOLOGIES: A REVIEW OF THE CURRENT RESEARCH STREAMS
Authors: Trevisan Adriana Hofmann , Zacharias Isabela Simões , Liu Qinglan , Yang Miying , Mascarenhas Janaina 
Published: August 2021

AbstractThe interest in the Circular Economy (CE) has grown in recent years. Digital technologies (DTs) have demonstrated a potential synergy to achieve circular goals at the micro, meso, and macro-level. Although several studies in literature explore DTs and CE linkage, they have not been identified according to their primary research themes. This paper aims to identify the main research streams addressing CE and DTs. From a Systematic Literature Review and Content Analysis, we reviewed 40 articles and classified three primary research streams. (1) Industry 4.0 (I4.0) focuses on the relevance and role of I4.0 in the transition to a CE. (2) The Business research stream evaluated the connection between digital transformation and business. (3) The Sustainability research stream discusses sustainability issues such as waste management and smart cities. Based on the analyzed studies' purposes and gaps, we provide a research agenda for further research. Additionally, we explain the implications of DTs and CE to research on engineering design. Our paper guides researchers in their future research to focus on gaps that have not been answered and position their studies according to their research streams.
CITIZEN PROFILES OF RESIDUAL WASTE SEPARATION BEHAVIOUR
Authors: Kamoen Ceri , Karahanoglu Armagan 
Published: August 2021

AbstractThe impact of human behaviour on climate change is getting more apparent every day. Citizens are encouraged and sometimes forced to change their waste separation behaviour to reduce their effect on this global challenge. One way to achieve this is to reduce the amount of fine and bulky residual waste that ends in landfill or is incinerated. Studies show that this can be achieved by active, efficient, and correct household participation. Multiple intervention strategies are being tried out, while the European Union statistics show that the numbers are not at the desired level yet. To improve the waste separation practices, understanding the motivation and drivers of (correct) waste separation behaviour is of high importance for the current strategies' success. In this paper, based on the Self-Determination Theory, we propose "citizen-profiling" framework, which consists of six citizen profiles, that illustrates citizens' motivations and drivers of residual waste separation behaviour. We end this paper, with discussions on motivating the citizens to contribute to waste separation actively.
CREATION OF DIGITAL TWINS - KEY CHARACTERISTICS OF PHYSICAL TO VIRTUAL TWINNING IN MECHATRONIC PRODUCT DEVELOPMENT
Authors: Sturm Carolin , Steck Michael , Bremer Frank , Revfi Sven , Nelius Thomas , Gwosch Thomas , Albers Albert , Matthiesen Sven 
Published: August 2021

AbstractDue to the falling costs of computational resources and the increasing potential of data acquisition, interest in digital twins, a virtual copy of the physical original, and their industrial application is increasing. Nevertheless, there is limited published work on how to support the process of physical to virtual twinning and what its key aspects are. The aim of this study is to present insights with regards to physical to virtual twinning gained from modelling projects in mechatronic product development. We conducted a survey and in-depth interviews with members of modelling projects. In the surveys and interviews we identified how physical products and virtual models were linked, which virtual models were used and which general challenges and key aspects are considered important by the project members. Our findings show that the key characteristics that pose challenges to modelling regarding physical to virtual twinning are model granularity, model validation, and model integration and interconnectivity.
A DESIGN RATIONALE ANALYSIS METHOD TOWARDS ROBUST ARTIFACT DESIGN
Authors: Tsutsui Yusuke , Mitake Yuya , Sholihah Mar'atus , Hosono Shigeru , Shimomura Yoshiki 
Published: August 2021

AbstractTo design a more robust artifact, an artifact design based on a design rationale analysis is pivotal. Errors in previous design rationales that led to the degradation of artifact robustness in the past provide valuable knowledge towards improving the robust design. However, methods for exposing and analysing errors in design rationale remain unclear. This paper proposes a structured method for a design rationale analysis based on logical structuring. This method provides a well-constructed means of identifying and analysing errors in design rationale from the perspective of knowledge operation.
DECOMPOSITION AND RECOMPOSITION STRATEGIES OF PROFESSIONAL ENGINEERING DESIGN TEAMS
Authors: Milovanovic Julie , Gero John , Becker Kurt 
Published: August 2021

AbstractDesigners faced with complex design problems use decomposition strategies to tackle manageable sub-problems. Recomposition strategies aims at synthesizing sub-solutions into a unique design proposal. Design theory describes the design process as a combination of decomposition and recomposition strategies. In this paper, we explore dynamic patterns of decomposition and recomposition strategies of design teams. Data were collected from 9 teams of professional engineers. Using protocol analysis, we examined the dominance of decomposition and recomposition strategies over time and the correlations between each strategy and design processes such as analysis, synthesis, evaluation. We expected decomposition strategies to peak early in the design process and decay overtime. Instead, teams maintain decomposition and recomposition strategies consistently during the design process. We observed fast iteration of both strategies over a one hour-long design session. The research presented provides an empirical foundation to model the behaviour of professional engineering teams, and first insights to refine theoretical understanding of the use decomposition and recomposition strategies in design practice.
DEEPER COMPREHENSION OF BASIC ENVIRONMENTAL ISSUES THROUGH SERIOUS GAME
Authors: Kozderka Michal , Rose Bertrand 
Published: August 2021

AbstractDuring the last three decades we observe growing use of ecodesign, but we observe also misuse of ecodesign methods, leading often to time and financial loss. In coherence with several failure analysis and with our observation, we base our work on a hypothesis: Misuse of ecodesign is often caused by lack of basic comprehension of environmental issues: Non linearity of the processes, their inertia and their excessive costs.Building on this hypothesis, we decided to enhance our education program with an innovative serious game. The goal is to achieve comprehension of the basic environmental issues. Innovation of the game lies in revealing to students at the end of the game, that the fictive initial situation of the game corresponded to a starting point of a real catastrophe. Students can thus not only compare their decisions with those of real leaders, but also to understand how and why bad decisions were taken.Experiments indicate that students who played the game tend to evaluate environmental problems, while those who followed a lecture tend to describe them. This trend (going further than to a description) seems to be useful in decision making and in deployment of ecodesign methods.
Factorial and discriminant analysis on non-carcass components of Berganês lambs from different sexual classes and crossbreeding
Authors: Silva Filho José Renaldo Vilar da , Moura Neto João Bandeira de , Santos Lays Thayse Alves dos , Ferreira Clebson Oliveira , Rodrigues Rafael Torres de Souza , Arandas Janaina Kelli Gomes , Ribeiro Maria Norma , Voltolini Tadeu Vinhas 
Published: August 2021

AbstractThe aim of this study was to evaluate the non-carcass components (NCC) of Berganês ecotype lambs of different sexual classes and genotypes using univariate and multivariate statistics, carrying out two experimental trials. In order to evaluate the effects of the sexual class, non-castrated males (BNC), castrated males (BC) and females (BF) of Berganês ecotype lambs were used, with mean initial body weight of 27 ± 3.1 kg. To evaluate crossbreeding, non-castrated male lambs of the genotypes Berganês (BG), Berganês × Santa Inês (BSI) and Berganês × Dorper (BD) were used, as well as the control Dorper × Santa Inês (DSI), all with mean initial body weight of 28 ± 3.8 kg. The weight and yield of the total by-products was higher for BNC. Regarding the genotype, BSI showed higher weight and yield of internal fat, but the weight and yield of the total by-products was higher for BG and BD. In factorial analysis (FA), the NCC, more correlated with empty body weight (EBW) and total weight gain (TWG), showed higher eigenvectors for factor 1. For factor 2, the weights and yields of internal fat and total viscera obtained higher eigenvectors. The discriminant analysis (DA) classified 100% of individuals in their respective sexes and genotypes. Therefore, the FA indicated that, among the NCC evaluated, the weights of liver, kidneys, GIT, skin and feets are determinant for obtaining EBW and TWG. The classification achieved by the DA indicates that the sexual classes and genotypes are heterogeneous.
The effect of coronavirus disease 2019 on the hearing system
Authors: Gedik Ö , Hüsam H , Başöz M , Tas N , Aksoy F 
Published: August 2021

AbstractObjectiveThis study aimed to evaluate different auditory regions with audiological tests, based on the presumption that there may be damage to the structures in the hearing system after coronavirus disease 2019.MethodsTwenty individuals with no history of coronavirus disease 2019 and 27 individuals diagnosed with coronavirus disease 2019 were compared. Pure tone, speech and extended high-frequency audiometry, acoustic immitansmetry, transient evoked and distortion product otoacoustic emissions testing, and auditory brainstem response testing were conducted.ResultsThe pure tone audiometry and extended high-frequency mean threshold values were higher in the coronavirus disease 2019 group. The transient evoked otoacoustic emissions signal-to-noise ratios were bilaterally lower at 4 kHz in individuals with a coronavirus disease 2019 history. In the auditory brainstem response test, only the interpeak latencies of waves III–V were significantly different between groups.ConclusionCoronavirus disease 2019 may cause damage to the hearing system. Patients should be followed up in the long term with advanced audiological evaluation methods in order to determine the extent and level of damage.
Risk of suicide in patients who present to hospital after self-cutting according to site of injury: findings from the Multicentre Study of Self-harm in England
Authors: Geulayov Galit , Casey Deborah , Bale Elizabeth , Brand Fiona , Clements Caroline , Farooq Bushra , Kapur Nav , Ness Jennifer , Waters Keith , Patel Anita , Hawton Keith 
Published: August 2021

AbstractBackgroundWe compared the risk of death by suicide following hospital presentation for self-harm according to site of self-cut/stab.MethodWe included 54 999 self-harm presentations (involving 31 419 individuals) to hospitals in the Multicentre Study of Self-harm in England (1/1/2004–31/12/2014), with mortality follow-up to 31/12/2019. Information on method of self-harm was obtained through monitoring in hospitals. Information about mortality was obtained through linkage with NHS Digital. We assessed the association of site of self-cut with death by suicide using mixed effect models.ResultsIn total, 10 790 (19.6%) hospital presentations involved self-cutting/stabbing, 7489 of which (69.4%) were due to laceration to the arm/wrist alone, 1846 episodes (17.1%) involved cutting elsewhere on the body, and 1455 (13.5%) were due to laceration to unknown site. Controlling for confounders, presentation to a hospital following self-cut/stab to bodily parts other than wrist/arm was associated with greater chance of subsequent suicide relative to presentation after self-poisoning alone [adjusted odds ratio (aOR) 1.75, 95% confidence interval (CI) 1.03–2.96, p = 0.038]. The likelihood of suicide after presentation for cutting/stabbing the wrist/arm alone was comparable to that of patients who had self-poisoned alone. Presentations after laceration involving the neck were associated with a four-fold greater chance of subsequent suicide relative to self-poisoning (aOR 4.09, 95% CI 1.80–9.30, p = 0.001).ConclusionsPatients who attend hospital after self-cutting/stabbing are a heterogeneous group in terms of characteristics, methods of cutting/stabbing and risk of subsequent suicide. Risk of suicide is greater in individuals who self-cut/stab to parts of the body other than the wrist or arm, especially the neck.
The Perceived Occupational Stress Scale
Authors: Marcatto Francesco , Di Blas Lisa , Luis Ornella , Festa Simone , Ferrante Donatella 
Published: August 2021

Abstract. This article aims to present the development and test the psychometric properties of the Perceived Occupational Stress (POS) scale, a new brief instrument aimed at rating a worker’s perception of feeling stressed at work. Six studies are conducted on an overall sample of 1,805 Italian workers, to examine both the construct and concurrent validity of the POS scale. The results demonstrate the high internal consistency (α = .82) and test-retest reliability ( r = .86) of the POS scale, as well as its structural validity and concurrent validity with the Maslach Burnout Inventory ( r = .68 with Emotional Exhaustion) and the Effort-Reward Imbalance Questionnaire ( r = .62 with Imbalance and r = .51 with Overcommitment). Moreover, the POS scale is determined to uniquely contribute toward predicting stress-related health complaints, over and above indicators of workplace stressors, as measured by the Health and Safety Executive Management Standards Indicator Tool ( R2change = .06). Overall, the present findings indicate that the POS scale is a valid and reliable instrument for self-reporting occupational stress levels, and it could be used together with existing risk assessment measures of stress, to obtain a comprehensive evaluation of work-related stress.
The Lunar Mare Ring‐Moat Dome Structure (RMDS) Age Conundrum: Contemporaneous With Imbrian‐Aged Host Lava Flows or Emplaced in the Copernican?
Authors: Zhang Feng , Head James W. , Wöhler Christian , Basilevsky Alexander T. , Wilson Lionel , Xie Minggang , Bugiolacchi Roberto , Wilhelm Thorsten , Althoff Stephanie , Zou Yong L. 
Published: August 2021

AbstractRing‐moat dome structures (RMDSs) are small circular mounds of diameter typically about 200 m and ∼3–4 m in height, surrounded by narrow, shallow moats. They occur in clusters, are widespread in ancient Imbrian‐aged mare basalt host units and show mineralogies comparable to those of their host units. Based on these close associations and similarities, a model has been proposed for the formation of RMDS as the result of late‐stage flow inflation, with second boiling releasing quantities of magmatic volatiles that migrate to the top of the flow as magmatic foams and extrude through cracks in the cooled upper part of the flow to produce the small RMDS domes and surrounding moats. In contrast to this model advocating a contemporaneous emplacement of RMDSs and their host lava flows, a range of observations suggests that the RMDS formed significantly after the emplacement and cooling of their host lava flows, perhaps as recently as in the Copernican Period (∼1.1 Ga to the present). These observations include: (a) stratigraphic embayment of domes into post‐lava flow emplacement impact craters; (b) young crater degradation age estimates for the underlying embayed craters; (c) regolith development models that predict thicknesses in excess of the observed topography of domes and moats; (d) landform diffusional degradation models that predict very young ages for mounds and moats; (e) suggestions of fewer superposed craters on the mounds than on the adjacent host lava flows, and (f) observations of superposed craters that suggest that the mound substrate does not have the properties predicted by the magmatic foam model. Together, these observations are consistent with the RMDS formation occurring during the period after the extrusion and solidification of the host lava flows, up to and including the geologically recent Late Copernican, that is, the last few hundreds of millions of years of lunar history. We present and discuss each of these contradictory data and interpretations and summarize the requirements for magma ascent and eruption models that might account for young RMDS ages. We conclude with a discussion of the tests and future research and exploration that might help resolve the RMDS age and mode of emplacement conundrum.
Spatiotemporal Methane Emission From Global Reservoirs
Authors: Johnson Matthew S. , Matthews Elaine , Bastviken David , Deemer Bridget , Du Jinyang , Genovese Vanessa 
Published: August 2021

AbstractInland aquatic systems, such as reservoirs, contribute substantially to global methane (CH4) emissions; yet are among the most uncertain components of the total CH4 budget. Reservoirs have received recent attention as they may generate high CH4 fluxes. Improved quantification of these CH4 fluxes, particularly their spatiotemporal distribution, is key to realistically incorporating them in CH4 modeling and budget studies. Here we report on a new global, gridded (0.25° lat × 0.25° lon) study of reservoir CH4 emissions, accounting for new knowledge regarding reservoir areal extent and distribution, and spatiotemporal emission patterns influenced by diurnal variability, temperature‐dependent seasonality, satellite‐derived freeze‐thaw dynamics, and eco‐climatic zone. The results of this new data set comprise daily CH4 emissions throughout the full annual cycle and show that reservoirs cover 297 × 103 km2 globally and emit 10.1 Tg CH4 yr−1 (1σ uncertainty range of 7.2–12.9 Tg CH4 yr−1) from diffusive (1.2 Tg CH4 yr−1) and ebullitive (8.9 Tg CH4 yr−1) emission pathways. This analysis of reservoir CH4 emission addresses multiple gaps and uncertainties in previous studies and represents an important contribution to studies of the global CH4 budget. The new data sets and methodologies from this study provide a framework to better understand and model the current and future role of reservoirs in the global CH4 budget and to guide efforts to mitigate reservoir‐related CH4 emissions.
TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation
Authors: Li Mi , Wu Wei , Deng Sisi , Shao Zengwu , Jin Xin 
Published: August 2021

AbstractOsteosarcoma is one of the most common primary malignancies in bones and is characterized by high metastatic rates. Circulating tumor cells (CTCs) derived from solid tumors can give rise to metastatic lesions, increasing the risk of death in patients with cancer. Here, we used bioinformatics tools to compare the gene expression between CTCs and metastatic lesions in osteosarcoma to identify novel molecular mechanisms underlying osteosarcoma metastasis. We identified TRAIP as a key differentially expressed gene with prognostic significance in osteosarcoma. We demonstrated that TRAIP regulated the proliferation and invasion of osteosarcoma cells. In addition, we found that TRAIP promoted KANK1 polyubiquitination and subsequent degradation, downregulating IGFBP3 and activating the AKT pathway in osteosarcoma cells. These results support the critical role of the TRAIP/KANK1/IGFBP3/AKT signaling axis in osteosarcoma progression and suggest that TRAIP may represent a promising therapeutic target for osteosarcoma.