bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological study of Acute Encephalitis Syndrome and Japanese Encephalitis burden in Sivasagar district of Assam, India
Authors: Ahmed Rahim Ali , Konwar Daisy , Swargiary Ananta , Shankar Hari , Singh Kuldeep , Bordoloi Rimen 
Published: December 2021

Abstract
Japanese Encephalitis (JE) is among the most common cause of viral encephalitis in human beings caused by the Japanese Encephalitis virus (JEV). It is found worldwide, especially in Southeast Asia and less commonly in the western pacific regions and Australia.North East India is identified as hotspot for Japanese encephalitis and is considered a major health problem in Assam. The present study assesses the epidemiology of Acute Encephalitis Syndrome (AES) and JE cases of the Sivasagar district of Assam for 2011-20.Epidemiological data of AES and JE such as disease burden, case fatality rate (CFR), etc. were collected from NVBDCP Unit of Sivasagar district. Data were obtained as a part of routine AES/JE control programme for the period 2011-20. The overall AES and JE casesduring 2011-20 were 1081 and 588, and death cases 333 and 180, respectively.The CFR of the district was found to be 30.61%. AES and JE cases were highest in Galekey and Patsaku block. The AES/JE cases were significantly higher in elderly (>30 years) and male population of the district. The peak AES/JE active and death cases were reported in June and July in the study period. Routine JE vaccination was found to be carried out since 2011-20 in the agegroup 9-18 months, covering more than 50% of the target population size. Similarly, during the 2011-12 and 2014-15, JE vaccination campaign was carried out in 1-15- and 16-60-years age-group. The prevalence of AES/JE cases in the Sivasagar district of Assam is declining. Nevertheless, there is an urgent need to intensify the AES/JE surveillance programme to detect the cases and develop strategy for better JE management. The immunization coverage for 9-18 months should be increased.
Sudan low changes affecting rainy days in southwestern Iran over six decades (1957–2019)
Authors: Mohammadi Fahimeh , Pazhoh Farshad , Hombari Farzaneh Jafari 
Published: December 2021

Abstract
The present study evaluated the dynamic changes in Sudan low systems over six decades (1957–2019), which were classified based on solar cycles. Rainfall days were extracted in January using data from 42 synoptic stations in the south and southwest regions of Iran. Then, the rainy days due to the Sudan low system were separated from the precipitation of the other atmospheric systems using the visual analysis of the maps. The synoptic analysis indicated that the sea level pressure has been decreasing at all sampling stations from the first to the sixth decade. Furthermore, decreasing elevation to −80 m (negative anomaly) in the 500 hPa level atmosphere from the first decade to the sixth decade indicated further atmospheric instability and more strengthening of the Sudan low compared to previous decades. The contribution of advection moisture to the area increased within the region at 700 hPa. This implies that the role of the transferred moisture from the intertropical convergence zone is increasing in the systems transferred from Sudan and in the study area. In general, the share of Sudan low precipitation is increasing in the south and southwest regions of Iran. This result is a positive effect of the climate change on the study area.
Characteristics of carbon source greenhouse gas flux in the water–air formation in the middle and upper reaches of the Three Gorges Reservoir
Authors: Qin Yu , Yu Zongtai , Gou Yujia , Liu Zhengmian 
Published: December 2021

Abstract
This study selected five points in the middle and upper mainstream of the Three Gorges Reservoir area. Starting from May 2016, the greenhouse gases CO2 and CH4 from the water–air formation at the sampling points have been monitored month by month for 10 months. Using the headspace balance method and the thin boundary layer model estimation method, we obtained the CO2 and CH4 partial pressure ranges and the water–air formation diffusion flux at the mainstream point. It is found that the CH4 partial pressure of water body is significantly positively correlated with water temperature, and significantly negatively correlated with DO; the CH2 partial pressure of water body is positively correlated with water temperature, but negatively correlated with conductivity, DO, pH and wind speed. The diffusion fluxes of CH4 and CO2 at the water–air formation are positively correlated with CH4 partial pressure and water temperature, and negatively correlated with ph, DO and conductivity. It is also found that the reservoir has a certain mitigation effect on the release of CO2 from the river water body, and the CH4 diffusion flux at the water–air formation is roughly equivalent.
A EXPERIÊNCIA DO GRUPO SAÚDE E BEM-ESTAR FURB NA REDE FEMININA DE COMBATE AO CÂNCER DE BLUMENAU (SC), BRASIL
Authors: Ceccato Monica Weiler , Aita Cléria Becker , Tensini Ana Cláudia , Kohls Cheila Carolina , Martinez Amanda , Westphal Camila Michelle , Losi Joana , Pereira Alice Inara , Cruz Sabrida 
Published: December 2021

Saúde e Bem-Estar é um Projeto de Extensão da Universidade Regional de Blumenau. Seu objetivo é contribuir com a prevenção e promoção da saúde e do bem-estar das mulheres da Rede Feminina de Combate ao Câncer de Blumenau/SC. Sua metodologia é educação em saúde com a prática de grupos e oficinas. De acordo com o Edital PROEXT 2016 MEC/SESu e Resolução FURB 24/2004, este projeto possui como área temática principal o eixo Saúde e sub-áreas: Saúde da Mulher, Saúde das Mulheres e Saúde do Trabalhador. Em relação aos Objetivos do Desenvolvimento Sustentável, relaciona-se com o ODS 3 Boa Saúde e Bem Estar e, indiretamente com vários outros, haja visto que a promoção de saúde e qualidade de vida está relacionada com as várias dimensões do desenvolvimento sustentável. As mulheres participantes relatam melhora da funcionalidade nas atividades de vida diária, da consciência corporal e do retorno ao trabalho.
Projeto Vernáculo: a arte e o artefato popular do Rio Grande do Norte em destaque
Authors: Ramos Everardo Araújo , Bessa Olavo Fontes Magalhães 
Published: December 2021

O artigo Projeto Vernáculo: a arte e o artefato popular do Rio Grande do Norte em destaque de autoria deEverardo Araújo Ramos, apresenta um projeto de pesquisa e extensão que trata da produção da arte e do artefato a partir de técnicas tradicionais, quase sempre por pessoas de pouca ou nenhuma instrução formal.
Diagnostic, Prognostic, and Therapeutic Value of miR-148b in
Human Cancers
Authors: Bahrami Afsane , Ferns Gordon A. 
Published: December 2021

:
MicroRNAs (miRs) is a class of conserved, small, noncoding RNA molecules
that modulate gene expression post-transcriptionally. miR-148b is a member of miR-
148/152 family generally known to be a tumor suppressor via its effect on different
signaling pathways and regulatory genes. Aberrant expression of miR-148b has recently
been shown to be responsible for tumorigenesis of several different cancer types. This
review discusses the current evidence regarding the involvement of miR-148b
expression in human cancers and its potential clinical importance for tumor diagnosis,
prognosis, and therapeutics.
Physiological and Pathophysiological Role of Cysteine Metabolism in
Human Metabolic Syndrome
Authors: Muthuraman Arunachalam , Ramesh Muthusamy , Shaikh Sohrab A. , Aswinprakash Subramanian , Jagadeesh Dhamodharan 
Published: December 2021

Abstract:
Cysteine is one of the major intermediate products of cellular amino-acid metabolism. It is a semi-essential amino acid for protein synthesis. Besides, it is also employed in the regulation of major endogenous anti-oxidant molecules i.e., reduced glutathione (GSH). Further, it is a precursor of multiple sulfur-containing molecules like hydrogen sulfide, lanthionine, taurine, coenzyme A and biotin. It is also one of the key molecules for post-translational modifications of various cellular proteins. In physiological conditions, it is employed in the sulfhydration process and plays a key role in the physiology modification of the inflammatory process in various organs, including the neurological system. The catabolism of cysteine is regulated by cysteine dioxygenase enzyme activity. The dysregulated conditions of cysteine and cysteine-associated hydrogen sulfide metabolism are widely employed in the acceleration of the neurodegenerative process. Moreover, the upregulation of cysteine and hydrogen sulfide synthesis occurs via the reverse trans-sulfuration process. This process helps to manage the worsening of a pathological condition of a cellular system. Moreover, it is also employed in the accumulation of homocysteine contents. Further, both cysteine and homocysteine molecules are widely accepted as biomarkers for various types of diseases. Therefore, the targets involved in the regulation of cysteine have been considered as valid targets to treat various disorders like cardiac disease, ischemic stroke, diabetes, cancer, and renal dysfunction.
Differential Proliferative and Cytotoxic Effect of Selected Components of
Essential Oils on Human Glioblastoma Cells
Authors: Sheikh Sumbla , Sturzu Alexander , Kalbacher Hubert , Nägele Thomas , Ernemann Ulrike , Heckl Stefan 
Published: December 2021

Background:
In the study of bioactive agents from traditional medicine, mono- and
sesquiterpenes represent the main ingredients of essential oils. Till now, only thymoquinone and
perillyl alcohol have been clinically tested on glioblastoma.

Objective:
In the present study, we examined the effect of ten different essential oils on three human
glioblastoma cell lines and one healthy human cell line.

Methods:
We used confocal laser scanning microscopy, flow cytometry, and cell growth analysis
to evaluate cell morphology changes, membrane disruption effects, acute cytotoxicity and effects
on the proliferation rate caused by the essential oils pinene, geraniol, eucalyptol, perillaldehyde, limonene,
and linalool, perillyl alcohol, myrcene, bisabolol and valencene on human cells. Caspase
3/7 activity was measured to observe apoptosis induced by the essential oils.

Results:
We found that the cytotoxicity concentrations varied not only between different essential
oils but also among different cell lines. Acute cytotoxicity of essential oils was based on cell membrane
disruption and that HEK cells were affected to a much higher degree than the Glioblastoma
cells. Vacuoles found in surviving glioblastoma cells appeared to be a factor in this effect.

Conclusion:
Caspase activity did not correlate with the membrane damage observed in the flow cytometry
experiments. This is especially evident in the HEK cells that only showed apoptosis with
two out of ten essential oils. Comparison of the effects of other essential oil to perillyl alcohol,
which is already used in glioblastoma therapy, revealed perillaldehyde and valencene as two new
candidate substances that showed even stronger anti-glioblastoma effects in all experiments.
Weight Gain and Loss in Cancer Patients Undergoing Chemotherapy: Importance of Dose Adjustment
Authors: de Lima Fernandes Maria Ayanny , de Aguiar Silva Andreza Tallyne , Cavalcanti Iago Dillion Lima , de Medeiros Adrya Lúcia Peres Bezerra , de Oliveira Lima Lígia Maria , de Castro Gomes Tâmara Kelly 
Published: December 2021

Introduction:
The established dose of chemotherapy is based on the values of the patient's
body weight, where variations during treatment can increase the toxicity of chemotherapy, with
the development of nephrotoxicity, among other toxicity profiles, as well as in cases of weight
gain, patients may receive low doses and compromise the therapeutic response to the tumor.

Objective:
To evaluate weight gain and loss in cancer patients undergoing chemotherapy.

Methods:
Longitudinal analytical study with patients at the end of chemotherapy treatment of both
genders. The type, location of the tumor and the antineoplastic agent used were collected from the
medical records, as well as height and weight at the beginning of treatment. At the time of collection,
anthropometric assessment was performed using body mass index, arm circumference, arm
muscle circumference, triceps skinfold thickness and percentage of weight loss.

Results:
Among the patients included in the study, 47.5% had a weight gain of around 2.5 kg,
while the remaining patients (52.5%) had a weight loss of around 2.8 kg. Of the patients who had
GFR, 55.5% had severe PP, 33.4% had no significant loss and 11.1 had significant loss. In the current
study, only 22% had a GFR <60ml/min/1.73m2, but they would already need to readjust the
medication calculation.

Conclusion:
It is important to evaluate body surface variations and also the GFR to adjust the dose
of the antineoplastic agent and to prevent or minimize nephrotoxicity, as well as to reduce the risk
of underdosing and inefficiency of the therapy.
Internet Addiction, Depression and Relation with Academic Failure in Students of Allied Medical Sciences, Semnan, Iran
Authors: Shayestefar Mina , Saffari Mohadese , Mahmoudi Milad Salaj , Razyani Ehsan 
Published: December 2021

Background:Internet addiction, which is a result of increasing inevitable use of the Internet and smartphones, causes discomfort and serious social and occupational problems that can consequently lead to some mental disorders, such as depression. On the other hand, depression and Internet addiction are factors affecting students' academic performance.Objective:This study aimed to investigate Internet addiction, depression and their relation with academic failure in students of Semnan Allied Medical Sciences.Methods:In this cross-sectional study, all students who were in the 3rd and higher semesters were examined. Three questionnaires (demographic, Beck Depression Inventory, and the Internet Addiction Test by Young) were used. The academic failure was assessed using the student's grade point average in the previous 3 semesters. Collected data were analyzed through descriptive and inferential statistics methods at the significance level of 0.05.Results:170 students participated in this study. The correlation between depression and grade point average changes was found to be negative (r=-0.19) and significant (p=0.01). Moreover, a positive (r=0.39) and significant (p=0.01) correlation was observed between depression and internet addiction scores. Binary logistic regression analysis also indicated that students' depression score (P=0.04, OR1.04, CI 95%=1-1.08) and sex (P=0.008, OR=0.37, CI 95% = 0.17-0.77) can predict academic failure.Conclusion:Due to the observation of internet addiction and depression in the students and effects of these disorders on their academic performance, it is necessary to educate students and families, identify risk factors and provide solutions to deal with them.
READING SĪTĀ’S LETTER ON OLD JAVANESE RĀMĀYAṆA KAKAWIN ON THE BASIS OF CANDRAKIRAṆA AS PROSODIC TREATISE
Authors: Aminullah Zakariya Pamuji 
Published: December 2021

The study presented in this article focuses on the signification of the poetic metres and the theory of rasa expounded in Candrakiraṇa, a guide to the composition of kakawin that is preserved in the scriptoriums of mountains. The use of the poetic metres and theory of rasa was examined in the text of Sītā’s letter to Rāma that was taken from the Rāmāyaṇa Kakawin. It was carried out on the three manuscripts of Candrakiraṇa preserved by the National Library of Indonesia (PNRI). The findings show that the use of śārdūlawikriḍita metre in Sītā’s letters results in a form of signification for particular aesthetic experiences (rasa), namely karuṇa (sympathy), bhayānaka (concern), śānta (peace) and śṛṅgara (love). Tulisan ini berfokus pada metrum dan teori rasa sebagai sarana pemaknaan yang dimuat dalam Candrakiraṇa, sebuah pedoman penulisan kakawin yang diwariskan di skriptorium-skriptorium pegunungan. Metrum dan teori rasa tersebut dikaji penggunaannya dalam surat Sītā kepada Rāma yang terkandung dalam Kakawin Rāmāyaṇa. Kajian ini melibatkan tiga manuskrip yang merupakan koleksi Perpustakaan Nasional Republik Indonesia. Hasil analisis menunjukkan bahwa metrum śārdūlawikriḍita yang digunakan pada surat Sīta menunjukkan bentuk pemaknaan untuk pengalaman-pengalaman estetika (rasa) tertentu, yaitu karuṇa (belas kasihan), bhayānaka (kekhawatiran), śānta (damai) dan śṛṅgara (cinta).
AN ECOFEMINIST READING OF TERE LIYE’S SI ANAK PEMBERANI
Authors: Nelfita Yulia , Andriyani Noni , Hayati Yenni 
Published: December 2021

This study is motivated by several reasons, and one of them is the lack of ecofeminist studies of Indonesian novels. The previous studies focus on novels written by women. Ecofeminist studies of Indonesian novels written by men have not been available so far. The analysis in this study is descriptive with hermeneutic technique of interpretation. This is part of a collective research project in this area. The study leads to a conclusion that Tere Liye’s novel, Si Anak Pemberani, contains some ecofeminist values. The most represented ones in the text are the natural ecofeminist values because there is essential relationship between women and nature. The least represented ones are the spiritualist ecofeminist values because the relationship between spirituality and nature is considered a mystical belief that is no longer relevant in modern society. Penelitian ini dilatarbelakangi oleh beberapa hal; salah satunya adalah belum adanya kajian ekofeminisme terhadap novel-novel Indonesia. Penelitian-penelitian yang sudah pernah dilakukan selalu dilakukan terhadap novel-novel yang ditulis oleh pengarang perempuan sementara penelitian ekofeminisme terhadap novel-novel Indonesia yang ditulis oleh laki-laki belum ada. Berdasarkan hal tersebut, masalah yang dideskripsikan dalam penelitian ini adalah “Bagaimanakah perspektif ekofeminis tercermin dalam novel Si Anak Pemberani karya Tere Liye?”. Teori yang digunakan adalah teori ekofeminisme yang meliputi (1) ekofeminisme alam, (2) ekofeminisme spriritualis, dan (3) ekofeminisme sosialis. Penelitian ini bersifat kualitatif dan merupakan penelitian kepustakaan. Metode analisis yang digunakan adalah metode deskriptif yang didukung oleh teknik hermeneutik. Hasil penelitian menunjukkan bahwa terdapat perspektif ekofeminis dalam novel Si Anak Pemberani karya Tere Liye. Aliran ekofeminisme yang dominan adalah aliran ekofeminisme alam karena pada dasarnya perempuan memiliki kedekatan dengan alam. Aliran yang paling sedikit ditampilkan adalah aliran ekofeminisme spiritualis karena pada zaman sekarang kedekatan secara spiritualis dengan alam dianggap hal mistis yang tidak lagi dipercayai oleh masyarakat.
The Phenomenon of Dynastic Politics Following Constitutional Court Decision Number 33/PUU-XIII/2015
Authors: Rafiqi Ilham Dwi , Ramadhan Febriansyah 
Published: December 2021

This research aims at breaking down the dynamics of dynastic politics after the 2020 simultaneous general election and the dynamics between the nomination of regional heads and dynastic politics following the issuance of the Constitutional Court decision no. 33/PUU-XIII/2005. The research found that this local politics phenomenon is triggered by the policy on regional autonomy and decentralization after reformation in bringing about new groups with family ties at local levels who occupy positions in the government. Going by the excuses of freedom and human rights, the groups in this dynastic politics have seen a gradual increase in quantity overtime. This increase happened after the Constitutional Court decision no. 33/PUU-XIII/2015 ruled in their favour. In the ruling, the Court took human rights into their main consideration for reversing the ruling against the ban on the dynastic politics law, which in Article 7 (r) UU 1/2015 may give the impression that the right to political participation is removed.
KEBERSYUKURAN DAN OPTIMISME MASA DEPAN SISWA SEKOLAH MENENGAH PERTAMA
Authors: Fu'ady Muh Anwar , Atiqoh Siti Vika Durrotul 
Published: December 2021

Individu yang mampu bersyukur atas apa yang dimilikinya akan lebih besar memiliki harapan dan kebahagiaan. Keterbatasan yang ada disekelingling siswa adalah juga termasuk dari nikmat yang perlu disyukuri. Harapan yang ada padanya memungkinkan siswa terhindar dari depresi, karena individu yang memiliki optimisme akan jarang terkejut ketika mengalami kesulitan, begitupun dengan segala kekurangan yang dihadapi. Sehingga kebersyukuran siswa berbanding lurus dengan optimisme masa depan mereka. Penelitian ini menggunakan analisis Korelasi Pearson. Siswa SMP Wahid Hasyim memiliki kebersyukuran dan optimisme masa depan dalam tingkatan sedang, dan kedua hal tersebut sangat dipengaruhi faktor internal dan eksternal secara bersamaan, yakni lingkungan sekolah, spirtualitas dan pola pikir.
Linking brain size in wild stream-dwelling brown trout with dietary supply of omega-3 fatty acids
Authors: Závorka Libor , Wallerius Magnus Lovén , Kainz Martin J. , Höjesjö Johan 
Published: December 2021

1. Omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) are key
structural lipids and their dietary intake is essential for brain
development of virtually all vertebrates. The importance of n-3 LC-PUFA
has been demonstrated in clinical and laboratory studies, but little is
known about how differences in availability of n-3 LC-PUFA in natural
prey influence brain development of wild consumers. The availability of
n-3 LC-PUFA in the prey communities is driven by primary producers and
it is therefore distributed heterogeneously, but predictably across
ecosystems, being higher in aquatic than in terrestrial food webs.
Consequently, the numerous consumers foraging on the interface of
aquatic and terrestrial food webs can differ substantially in their
intake of n-3 LC-PUFA, which may lead to in brain development, yet, this
hypothesis still remains to be tested.
2. Here we use the previously demonstrated shift towards higher reliance
on n-3 LC-PUFA deprived terrestrial prey of native brown
troutSalmo trutta living in sympatry with invasive brook
troutSalvelinus fontinalis to explore this hypothesis.
3. We found that the content of n-3 LC-PUFA in muscle tissues of brown
trout decreased with increasing consumption of n-3 LC-PUFA deprived
terrestrial prey. Brain volume was positively related to content of the
n-3 LC-PUFA, docosahexaenoic acid, in muscle tissues of brown trout.
4. Our study thus suggests that increased reliance on low quality diet
of n-3 LC-PUFA deprived subsidies from terrestrial food web can have a
significant negative impact on brain development of wild trout. These
findings provide the first evidence of an intra-specific link between
n-3 LC-PUFA content in natural prey and brain size of wild vertebrate
consumers.
5. Ongoing global change is predicted to reduce the availability of
dietary n-3 LC-PUFA across food webs. Therefore, our findings emphasise
the need for further research on how wild consumers adapt to the
shortage of dietary n-3 LC-PUFA in order to maintain optimal development
and functioning of their brain, which is crucial for their fitness.
Stochastic Jumping Robots for Large-scale Environmental Sensing
Authors: Hird Julian , Conn Andrew , Hauert Sabine 
Published: December 2021

Single-use jumping robots that are mass-producible and biodegradable
could be quickly released for environmental sensing applications. Such
robots would be pre-loaded to perform a set number of jumps, in random
directions and with random distances, removing the need for onboard
energy and computation. Stochastic jumpers build on embodied randomness
and large-scale deployments to perform useful work. This paper
introduces simulation results showing how to construct a large group of
stochastic jumpers to perform environmental sensing, and the first
demonstration of robot prototypes that can perform a set number of
sequential jumps, have full-body sensing, and are well suited to be
made biodegradable.

Corresponding author(s)
Email: a.conn@bristol.ac.uksabine.hauert@bristol.ac.uk