bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming the Temperature Effect on a Single Junction and Intermediate Band Solar Cells Using Optical Filter and SECs
Authors: Vahedi S , Eskandari Mohammad , Barzinjy Azeez , Rostami Ali , Dolatyari Mahboubeh , Rostami Ghasem 
Published: July 2021

Abstract
The performance of electronic devices, especially solar cells, at high temperatures is of primary interest to researchers. The design and construction of high-efficiency solar cells face some difficulties. One of these difficulties is the rising temperature, thus solar cells temperature assessment is essential to guarantee high performance. Normally, rising temperature, in solar cells, is associated with the normal ambient temperature and the produced internal temperature due to power dissipation. Accordingly, this investigation aims to reduce the effect of applied temperature from both sources. To reduce the destructive effect, the authors design a simple construction model that utilizes SiO2 and Si3N4 as a filtering layer. The outcomes of this study show that the power conversion is optimum. Si and SiC Solar cells both with and without using a filter are evaluated and compared. Finally, enhancement in power conversion efficiency and other characteristics has been investigated. The intermediate band solar cells were evaluated with both internal and external temperature effects. To reduce the internal temperature, the authors utilized a novel method for extracting the hot carriers from different energy levels by using multilevel energy selective contacts (ESCs). It was shown that ESCs promote efficiency and break the Shockley-Queisser limit.
Elucidation of new xylose metabolizing pathway in Pseudomonas gessardii VXlt-16 and its correlation with xylitol production from sugarcane bagasse hydrolysate
Authors: Ahuja Vishal , Mehta Sanjeev , Rathour Ranju Kumari , Sharma Vaishali , Rana Nidhi , Sheetal Sheetal , Bhatt Arvind Kumar , Kieliszek Marek 
Published: July 2021

Abstract
Scientific interventions have identified lignocellulosic biomass as potential raw material for various industrial processes. However toxic byproducts released during the process result in deterioration of environment to a greater extent. Microbes can utilize these wastes for production of products of commercial value like bio-fuels, protein, organic acids and xylitol. However, high production cost and astringent operating conditions have been the major bottlenecks for its commercial production. In microbes, xylose is metabolized by xylose isomerase (XI) and xylose reductase-xylitol dehydrogenase (XR-XDH) pathways, with later having ability to transform pure xylose as well as xylose rich lignocelluloses. Efforts to find hyper producer isolates for xylitol production resulted in identification of one such isolate Pseudomonas gessardii VXlt-16 (MG770460) by 16s rDNA sequencing. Statistical optimization resulted in 7.28 folds’ increase in xylitol yield with 64.76% xylose bioconversion. Conversion of xylose to xylitol even at large scale suggests the possible application of bacterial isolate for the production of this useful product at industrial scale.
Usefulness of Palliative Radiotherapy in Reducing the Frequency of Red Blood Cell Transfusion in Patients with Malignant Tumor Bleeding
Authors: Katano Atsuto , Yamashita Hideomi 
Published: July 2021

Abstract
Purpose: We aimed to evaluate the usefulness of palliative radiotherapy in reducing the frequency of red blood cell (RBC) transfusions in patients with malignant tumor bleeding as a quantitative value to evaluate the hemostatic effect.Patients and methods: In this study, we conducted a retrospective review of patients visiting our department between June 2013 and April 2021. All patients underwent RBC transfusions for 30 days before the initiation of radiotherapy. We determined the overall survival time and RBC transfusion-free time using statistical tests.Results: In total, 21 patients were enrolled in our study, including 13 women and 8 men; the median patient age was 63 years (range: 32 to 82 years). After radiotherapy, 19 of the 21 patients had a decreased frequency of requirement for RBC transfusion compared to that before radiotherapy. Fourteen patients had achieved an RBC transfusion-free state one month after radiotherapy. The estimated 1-year overall survival and RBC transfusion-free rates were 36.3% (95% confidence interval [CI]: 14.2%) and 66.7% (95% CI: 42.5%–42.5 %), respectively.Conclusion: The present study revealed a reduction in RBC transfusion after palliative radiotherapy in patients with malignant tumor bleeding. We believe that reducing the frequency of blood transfusions in patients with terminal conditions would have significant clinical benefits.
Effects of Waterlogging on Soybean Rhizosphere Microbial Community Profiled Using Illumina MiSeq, LoopSeq, and PacBio 16S rRNA Genes Sequences
Authors: TaoBing Yu , Lang Cheng , Qi Liu , ShaSha Wang , Yuan Zhou , Hongbin Zhong , Meifang Tang , Hai Nian , Tengxiang Lian 
Published: July 2021

Abstract
Background: Waterlogging on the global environment has led to a significant decline in crop yields. However, the response of plant-associated microbes to waterlogging stress on different soils is not known. Moreover, there are few reports on whether this response is influenced by different sequencing methods. In this study, the effects of waterlogging on soybean rhizosphere microbial structure on two types of soil were examined, using a short reading 16S rRNA sequencing variable region V4 and two full-length 16S rRNA sequencing variable regions V1-V9.Results: The results revealed some similarities and differences in three sequencing methods for soybean rhizosphere microbial response to waterlogging stress. Based on CPCoA analysis, all the sequencing methods showed that waterlogging on both types of soil significantly affected the bacterial community structure of the soybean rhizosphere, and increased the relative abundance of Geobacter. However, the full-length sequencing methods had higher classification resolution than short-read sequencing (except phylum level of all sequencing methods and class level of LoopSeq sequencing). Further, analysis on OTU level and network showed that waterlogging increased the abundance of some microorganisms related to nitrogen cycle using V4 sequencing, and microorganisms related to phosphorus cycling when using two full-length sequencing methods. This is in line with the core microbial analysis. Environmental factors affecting the structure of microbial communities differed among sequencing methods.Conclusions: In summary, this piece of work detected the effects of waterlogging on soybean rhizosphere microbes using three sequencing methods. Some functional microbes were enriched in the rhizosphere, which may benefit soybean in resisting waterlogging stress. On the other hand, there were several differences in results among the three sequencing methods which might affect the response of rhizosphere microbial structure to stress. Our analysis of sequencing methods on various levels provides some useful information on environmental samples sequencing.
A Novel Attributed Community Detection by Integration of Feature Weighting and Node Centrality
Authors: Rostami Mehrdad , Oussalah Mourad 
Published: July 2021

Abstract
Community detection is one of the basic problems in social network analysis. Community detection on an attributed social networks aims to discover communities that have not only adhesive structure but also homogeneous node properties. Although community detection has been extensively studied, attributed community detection of large social networks with a large number of attributes remains a vital challenge. To address this challenge, a novel attributed community detection method through an integration of feature weighting with node centrality techniques is developed in this paper. The developed method includes two main phases: (1) Weight Matrix Calculation, (2) Label Propagation Algorithm-based Attributed Community Detection. The aim of the first phase is to calculate the weight between two linked nodes using structural and attribute similarities, while, in the second phase, an improved label propagation algorithm-based community detection method in attributed social network is proposed. The purpose of the second phase is to detect different communities by employing the calculated weight matrix and node popularity. After implementing the proposed method, its performance is compared with several other state of the art methods using some benchmarked real-world datasets. The results indicate that the developed method outperforms several other state of the art methods and ascertain the effectiveness of the developed method for attributed community detection.
Clinical Manifestations of Orbital Involvement in IgG4-Related Disease: A Retrospective Study of 573 Patients
Authors: Gan Linyang , Luo Xuan , Fei Yunyun , Peng Linyi , Zhou Jiaxin , Li Jieqiong , Lu Hui , Liu Zheng , Zhang Panpan , Liu Xiaowei , Zhang Wen 
Published: July 2021

Abstract
Purpose: To investigate the clinical manifestations of orbital involvement in a large cohort of Chinese patients with IgG4-related disease (IgG4-RD). Methods: A total of 573 patients with IgG4-related disease were included. We described and compared the demographic, clinical, laboratory and histopathologic findings from 314 patients with IgG4-related ophthalmic disease (IgG4-ROD) and 259 with extra-ophthalmic IgG4-RD.Results: Male predominance was found significant in extra-ophthalmic IgG4-RD only. Patients with IgG4-ROD showed younger age at diagnosis and longer duration from onset till diagnosis. In patients with extra-ophthalmic IgG4-RD, the most commonly involved extra-ophthalmic organ was pancreas; while in IgG4-ROD patients, salivary gland was most frequently affected. Multivariate analysis exhibited IgG4-ROD was associated with allergy history, higher serum IgG4/IgG ratio, multiple organs involvement and sialoadenitis. Orbital images were reviewed in 173 (55.1%) IgG4-ROD patients. Fifty-one (29.5%) patients had multiple lesions. Lacrimal gland involvement was detected in 151 (87.3%) patients, followed by extraocular muscles (40, 23.1%), other orbital soft tissue (40, 23.1%) and trigeminal nerve (8, 4.6%). Biopsy was performed from various organs in 390 cases. A dense lymphoplasmacytic infiltration and fibrosis were the main feature in orbital specimens. Storiform fibrosis and obliterative phlebitis were absent in lacrimal gland.Conclusions: Lacrimal gland involvement was the most common orbital manifestation of IgG4-ROD. Patients with IgG4-ROD showed different characteristic in demographic, clinical, laboratory findings compared to patients with extra-ophthalmic IgG4-RD. These features might indicate potential differences in the pathogenesis of these two subgroups of IgG4-RD.
Feasibility Study Protocol: Investigating The Impact of Bleed Events On Anticoagulated Patients Diagnosed With Atrial Fibrillation Using Patient Reported Outcome Measures
Authors: Hutchings Hayley A , Lanyon Kirsty , Lister Steven , Alikhan Raza , Fegan Claire , Halcox Julian , Holland Gail , Hughes Arfon , Jenkins Rhys , Laing Hamish , Lobban Trudie , More Lianne , Owen Diane , Pollock Kevin G , Todd Ceri , Wareham Kathie 
Published: July 2021

Abstract
BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia. Oral anticoagulation therapies (OATs) are often prescribed in conjunction with medications to restore normal heart rate rhythm which can limit the risk of an AF-related stroke and systemic thromboembolism. However, they are associated with the serious side effect of bleeding. Both clinically relevant non-major bleeding (CRNMB) and major bleeding while anticoagulated are believed to have a significant impact on patient quality of life (QoL). There is currently limited research into the effect bleeding has on QoL. The aim of this study is to evaluate the feasibility of identifying and recruiting patients diagnosed with AF, who are taking OATs and have recently experienced a bleed and collecting information on their QoL.MethodsWe will recruit a minimum of 50 patients to this cross sectional, observational study. We will recruit from general practices, secondary care and through an online AF forum. We will ask participants to complete three validated patient-reported outcome measures (PROMs: EQ5D, AFEQT and PACT-Q), approximately four weeks following a bleed and again 3 months later. We will randomly select a subset of 10 participants (of those who agree to be interviewed) to undergo a structured interview with a member of the research team to explore the impact of bleeding on their QoL and to gain feedback on the three PROMs used. We will undertake a descriptive analysis of the PROMs and demographic data. We will analyse the qualitative interviews thematically to identify key themes. DiscussionWe aim to establish if it is possible to recruit patients and use PROMs to collect information regarding how patient QoL is affected when they experience either a CRNMB or major bleed, while taking OATs for the management of AF. We will also explore the appropriateness or otherwise of the three identified PROMs for assessing quality of life following a bleed. Trial registrationThe trial has been adopted onto the NIHR Portfolio (I.D. #47771) and registered with www.ClinicalTrials.gov (#NCT04921176) retrospectively registered in June 2021.
A Graphical Pressure Sensor Array With Multilayered Structure: Written Through Graphene Ink on Cellulose Paper Substrate
Authors: Ji Chao , Zhang Qiang , Li Qiang , Pei Zhen , Zhao Dong , Yuan Zhongyun , Wang Jie , Zhang Wendong , Sang Shengbo 
Published: July 2021

Abstract
Paper based flexible pressure sensors have received extensive attention due to their recoverability and accessibility. In this paper, we proposed graphical pressure sensors array with multilayered structure. A simple writing method was adopted to achieve the adsorption of sensitive materials on the fiber structure of cellulose paper. Pressure sensors with 1, 3, 5 and 7 stacked layers were fabricated and compared, respectively. The results show that the 7layers sensor combined high sensitivity (44 kPa-1) and fast time response (150 ms). The highly sensitive stacked paper-based sensor array realizes the pressure detection of objects and special-shaped surfaces. A pressure sensor base on commercial corrugated box was also fabricated to compare. The corrugated carton array was made to switch reminder devices for its convenience and accessibility. Since there are many scenarios that require a safe distance, especially under the influence of the COVID-19, the writable paper-based sensor array was used to realize graphical distance perception and warning.
Periostin: A Biomarker Useful in Treating Patients with Progressive Fibrosing Interstitial Lung Diseases
Authors: Takai Masayuki , Ono Junya , Okamoto Masaki , Fujimoto Kiminori , Kamei Ayami , Nunomura Satoshi , Nanri Yasuhiro , Ohta Shoichiro , Hoshino Tomoaki , Azuma Arata , Izuhara Kenji 
Published: July 2021

Abstract
Background: The concept of progressive fibrosing interstitial lung diseases (PF-ILD) has been recently proposed to describe a progressive phenotype in fibrosing ILDs, separate from the classical differential diagnosis of ILDs. However, we still do not know enough about how we can differentiate PF-ILD patients from non–PF-ILD patients in advance or how we can predict decline of lung function in PF-ILD patients. Periostin is a matricellular protein playing a critical role in the pathogenesis of pulmonary fibrosis significantly high in idiopathic pulmonary fibrosis patients. Methods: In this study, we applied three periostin ELISA systems—an original ELISA system recognizing total periostin, an ELISA system recognizing only the monomeric periostin, and a modified ELISA system that can measure periostin independently of the IgA complex established in this study—to serum from idiopathic interstitial pneumonia (IIP) patients to address whether periostin can differentiate PF-ILD from non–PF-ILD patients in advance, whether periostin can predict the decline of lung function in PF-ILD patients, and which ELISA system for periostin is the most suitable for these purposes.Results: We established the modified ELISA system using SS16A recognizing the R3 domain instead of SS18A recognizing the R1 domain as the primary mAb that can measure periostin independently of the IgA complex. All periostin values found by the three systems were significantly higher in PF-ILD patients than in healthy subjects in addition to SP-D and KL-6, whereas all the periostin values, but not SP-D or KL-6, could differentiate PF-ILD patients from patients with IIP other than PF-ILD, in the order of the monomer system, the modified system, and the original system. Moreover, the periostin values by all three systems, but not SP-D or KL-6, showed significant correlations with decline of either %VC or DL, CO, in order of the monomer system, the modified system, and the original system.Conclusions: Serum periostin, but not SP-D and KL-6, differentiates PF-ILD from non–PF-ILD and predicts decline of lung function in PF-ILD patients. The monomer periostin ELISA system is the best at doing so. These results demonstrate that periostin, particularly the monomeric form, is useful in treating PF-ILD patients.
Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non-Small Cell Lung Cancer Cells Through ATF4-AKT-Mtor Signaling Pathway.
Authors: Shao Shali , Du Yajing , Wu Duojiao , Wang Xiangdong , Qiao Tiankui 
Published: July 2021

Abstract
Cancer usually coexists with depression, and depression correspondingly influences the progress and prognosis of cancer. Antidepressants are often used on depression, so it’s meaningful to study how antidepressants affect the cancer. Recently, the antidepressants were reported to have an antiproliferation effect in different cancer. However, the specific molecular target in lung cancer remains unclear. In this study, we investigated how fluoxetine influenced different kind of cells and discovered the molecular basis of its inhibitory effect in lung cancer. CCK8 and immunofluorescence found that fluoxetine specifically inhibited the cell proliferation of H460 and A549 cells and induced autophagy. The analysis of the RNA sequence hinted that the ER stress-related protein and mTOR pathway were involved in the treatment of fluoxetine. Western blot results revealed that fluoxetine activated the endoplasmic reticulum (ER) stress pathway, including PKR-like ER kinase (PERK), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP), while inhibited the AKT/mTOR pathway. In addition, the transfection of ATF4 siRNA further discovered that ER stress participated in the inhibition of the AKT/mTOR pathway and the induction of antiproliferation and autophagy in the fluoxetine-treated cells. More importantly, fluoxetine was demonstrated to play cytotoxic activity in cancer cells without affecting normal cells. Our results showed that fluoxetine triggered the ATF4-AKT-mTOR signaling pathway to induce cell cycle arrest and autophagy to restraint cancer cells growth in lung cancer. This study results found that fluoxetine unaffected the proliferation of normal lung epithelial cells, providing a safe clinical therapeutic strategy for lung cancer patients with depression.
Construction and Validation of a Prognostic Risk Model Based on Autophagy-Related Genes in Hepatocellular Carcinoma Cells
Authors: Feng Rui , Li Jian , Xuan Weiling , Liu Hanbo , Cheng Dexin , Wang Guowei 
Published: July 2021

Abstract
Background

Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer and the main cause of cancer mortality. Its high complexity and dismal prognosis bring dramatic difficulty to treatment. Due to the disclosed dual functions of autophagy in cancer development, understanding autophagy-related genes devotes into seeking novel biomarkers for HCC.
Methods

Differential expression of genes in normal and tumor groups was analyzed to acquire autophagy-related genes in HCC. GO and KEGG pathway analyses were conducted on these genes. Genes were then screened by univariate regression analysis. The screened genes were subjected to multivariate Cox regression analysis to build a prognostic model. The model was validated by ICGC validation set.
Results

Altogether, 42 autophagy-related differential genes were screened by differential expression analysis. Enrichment analysis showed that they were mainly enriched in pathways including regulation of autophagy and cell apoptosis. Genes were screened by univariate analysis and multivariate Cox regression analysis to build a prognostic model. The model was constituted by 6 feature genes: EIF2S1, BIRC5, SQSTM1, ATG7, HDAC1, FKBP1A. Validation confirmed the accuracy and independence of this model in predicting HCC patient’s prognosis.
Conclusion

A total of 6 feature genes were identified to build a prognostic risk model. This model is conducive to investigating interplay between autophagy-related genes and HCC prognosis.
Trans-Arterial Embolization On A Catastrophic Primary Postpartum Hemorrhage Due To Arterial Aneurysm With Arteriovenous Fistula At Bilateral Lower Vagina: A Case Report
Authors: Wu Cheng-Hsien , Wong Yon-Cheong , Wu Patricia Wanping , Chueh Ho-Yen 
Published: July 2021

Abstract
Background: Failure of the primary management at controlling the post-partum hemorrhage (PPH) is occasionally encountered. A catastrophic cause of PPH as vagina arterial aneurysms with AVF is rare and not reported in English literature.Case presentations: We present a 34-year-old woman of arterial aneurysms with arteriovenous fistulas (AVF) at bilateral lower vagina causing intractable PPH with aggressive bleeding. By trans-arterial embolization (TAE) the bleeding is successfully controlled, and patient then could recover smoothly.Conclusion: These vascular anomalies being fierce culprit of the PPH would result in primary management failure. Knowledge of the possible etiology of post-partum hemorrhage is crucial for treatment management. This case report aims to point out a pivotal role of TAE at detecting and treating this unusual cause of PPH.