bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial metabolomics reveals localized impact of influenza virus infection on the lung tissue metabolome
Authors: Dean Danya A. , Klechka London , Hossain Ekram , Parab Adwaita R. , Eaton Krystin , Hinsdale Myron , McCall Laura-Isobel 
Published: November 2021

AbstractThe influenza virus (IAV) is a major cause of respiratory disease, with significant infection increases in pandemic years. Vaccines are a mainstay of IAV prevention, but are complicated by consideration of IAV’s vast strain diversity, manufacturing and vaccine uptake limitations. While antivirals may be used for treatment of IAV, they are most effective in early stages of the infection and several virus strains have become drug resistant. Therefore, there is a need for advances in IAV treatment, especially host-directed, personalized therapeutics.Given the spatial dynamics of IAV infection and the relationship between viral spatial distribution and disease severity, a spatial approach is necessary to expand our understanding of IAV pathogenesis. We used spatial metabolomics to address this issue. Spatial metabolomics combines liquid chromatography-tandem mass spectrometry of metabolites extracted from systematic organ sections, 3D models and computational techniques, to develop spatial models of metabolite location and their role in organ function and disease pathogenesis. In this project, we analyzed plasma and systematically sectioned lung tissue samples from uninfected or infected mice. Spatial mapping of sites of metabolic perturbations revealed significantly lower metabolic perturbation in the trachea compared to other lung tissue sites. Using random forest machine learning, we identified metabolites that responded differently in each lung position based on infection, including specific amino acids, lipids and lipid-like molecules, and nucleosides. These results support the implementation of spatial metabolomics to understand metabolic changes upon IAV infection and to identify candidate pathways to be targeted for IAV therapeutics.ImportanceThe influenza virus is a major health concern. Over 1 billion people become infected annually despite the wide distribution of vaccines, and antiviral agents are insufficient to address current clinical needs. In this study, we used spatial metabolomics to understand changes in the lung and plasma metabolome of mice infected with influenza A virus, compared to uninfected controls. We determined metabolites altered by infection in specific lung tissue sites and distinguished metabolites perturbed by infection between lung tissue and plasma samples. Our findings highlight the importance of a spatial approach to understanding the intersection between lung metabolome, viral infection and disease severity. Ultimately, this approach will expand our understanding of respiratory disease pathogenesis and guide the development of novel host-directed therapeutics.
Bacterial Sensitivity to Chlorhexidine and Povidone-Iodine Antiseptics Over Time: A Systematic Review and Meta-Analysis of Human-Derived Data
Authors: Aftab Raiyyan , Dodhia Vikash H , Jeanes Christopher , Wade Ryckie G 
Published: November 2021

AbstractBackgroundSurgical site infection (SSI) is the most common complication of surgery, increasing healthcare costs and hospital stay. Topical biocides such as chlorhexidine (CHX) and povidone-iodine (PVI) are used for skin antisepsis to minimise SSIs. There is an increasing concern of developing resistance to topical biocides, however the clinical implications of this remains unclear.OutcomesThe objective of this review was to determine whether the Minimum Bactericidal Concentration (MBC) for topical preparations of CHX or PVI have changed over time, in microbes relevant to SSI.MethodsWe searched for studies which reported the mean bactericidal concentration (MBC) of laboratory and clinical isolates of common SSI causing microbes to CHX and PVI. We excluded samples derived from non-humans and studies using antimicrobial solvents or mixtures of biocides with other active substances. MBC was pooled in random effects meta-analyses and change in MBC over time was explored using meta-regression.Results79 studies were including, analysing 6218 microbes between 1976 and 2021. Most studies used CHX (93%) and there was insufficient data for meta-analysis of PVI. Enterobacteriales had the highest MBC for CHX (20 mg/L [95% CI 14, 25]; I2 95%) whilst MRSA had the lowest (3 mg/L [95% CI 1, 2]; I2 93%). There was no change in MBC of CHX to Staphylococci (β 0.12 [-1.13, 1.37]; I2 99%) or Streptococci (β 0.13 [-0.35, 0.62]; I2 97%).ConclusionsThere is no evidence of change in susceptibility of common SSI-causing microbes to CHX over time. This study provides reassurance that the worldwide guidance that CHX should remain the first-choice agent for skin asepsis prior to surgery.
Factors correlated with the perceived usefulness of online reviews for consumers: a meta-analysis of the moderating effects of product type
Authors: Zhu Zhangxiang , Liu Jiapei , Dong Wei 
Published: November 2021

PurposeThe conclusions of studies on the factors correlated with the perceived usefulness of online reviews are inconsistent due to differences in research perspectives, research objects, research methods and data types. This study conducted a meta-analysis to verify a proposed model of perceived usefulness to obtain general conclusions.Design/methodology/approachA meta-analysis was conducted to study the factors correlated with the perceived usefulness of online reviews based on 51 studies.FindingsThe results indicate that, with the exception of negative reviews, the order of relevance for the perceived usefulness of online reviews is as follows: the trust tendency of review readers, review replies, review depth, review pictures, reviewer trustworthiness, positive reviews, reviewer expertise, review time and reviewer information disclosure. Perceived usefulness was significantly positively correlated with purchase intention. Review time, positive reviews and negative reviews were also more significantly correlated with perceived usefulness for search products than for experiential products. Review depth, reviewer trustworthiness, reviewer expertise and purchase intention had greater positive correlations with perceived usefulness for experiential products than for search products.Originality/valueThis study proposes an extended information adoption model based on argument quality and source credibility. The model includes personal factors such as the trust tendency of review readers, constructs a theoretical model of the factors correlated with the perceived usefulness of online reviews and considers the moderating effects of product type.
Value cocreation research in tourism and hospitality: a comparative bibliometric analysis
Authors: Liu Xinyi , Zeng Ying , He Juan , Li Zhiyong 
Published: November 2021

PurposeThe purpose of this study is to present a holistic review of journal articles on value cocreation in the tourism and hospitality field. By distinguishing similarities and differences in the contexts of China and other regions, the authors identify targeted research directions.Design/methodology/approachThis study collected 438 English articles and 31 Chinese articles on value cocreation in tourism and hospitality published in the Web of Science, Scopus and China National Knowledge Infrastructure online databases. After analyzing the study location of all articles in the sample, the authors identified 79 English-language articles that adopted China as the context of the study. The first data set included non-China-focused publications and the second data set included China-focused publications. A comparative bibliometric methodology was conducted.FindingsThe results indicate similarities and differences between the two data sets in terms of research methods, topics and future research directions. Seven major concepts were identified in the first data set: hospitality value cocreation; the value generation process; key stakeholders; outcome variables; the application of service-dominant logic; peer-to-peer accommodation and destination management. Four research focuses were identified in the second data set: the application of customer-dominant logic; the value generation process; resource integration and the cocreation experience.Research limitations/implicationsThis research contributes to the understanding of tourism and hospitality cocreation systems through literature analysis and encourages future research on the nexus of the Chinese and global contexts. This systematic investigation extends the concept of value cocreation by integrating its implementation process and value categories and further evaluates the consequences and benefits of value cocreation, which helps clarify how winners and losers can adjust their strategies accordingly.Originality/valueThe originality of this paper lies in the adopted comparative bibliometric analysis which comprehensively reviewed and compared the characteristics of value cocreation research across two contexts. In addition, the study dialectically assesses Chinese tourism cocreation phenomena and their impacts from a global perspective.
Unsafe at home: the increased trend of domestic violence during the COVID-19 pandemic in Bangladesh
Authors: Jahid Anita 
Published: November 2021

Purpose
The pandemic situation has increased the domestic violence rate against women and children significantly around the world. However, it is difficult to measure the accurate rate of increased domestic violence because of restrictions and limited mobility in accessing help and reporting. This paper aims to highlight the current situation of the novel coronavirus 2019 (COVID-19) pandemic and domestic violence in Bangladesh. It also states the challenges of the unprecedented situation and how to encounter increasing domestic violence cases.

Design/methodology/approach
This paper is a viewpoint of the COVID-19 pandemic and domestic violence situation in Bangladesh. Accordingly, this paper includes a comprehensive literature review that summarises related articles and newspapers on domestic violence.

Findings
Bangladesh is one of the most vulnerable countries to COVID-19 because of its most dense population. Currently, the COVID-19 virus is spreading rapidly in all parts of Bangladesh. In Bangladesh, the COVID-19 pandemic is increasing domestic violence for women and girls. Because of the lockdown, financial stress and livelihood scarcity, domestic violence rates show an increasing tendency that should not be overlooked to ensure the safety and security of women and girls in Bangladesh.

Originality/value
This paper delivers information about the current situation of COVID-19 in Bangladesh and the challenges of domestic violence that have risen. This paper will be helpful to policymakers, government and non-government officials for developing effective social safety net interventions.
Workplace learning experienced by employees in information technology-enabled work environments – a developing country experiences
Authors: Wickramasinghe Vathsala , Ramanathan Udayabanu 
Published: November 2021

PurposeThe purpose of this paper is to present the findings of a study that investigated workplace learning activities and drivers that enhanced learning as experienced by employees in Sri Lanka.Design/methodology/approachThis study was conducted in the knowledge process outsourcing sector, where employees perform knowledge work in flatter team-based structures with information technology-enabled work environments. From the 17 firms that volunteered to participate in the study, 239 technical/professional employees volunteered for the survey. Multiple regression analysis was used to identify the association between drivers of workplace learning and learning activities experienced by employees and whether individual demographic characteristics and the number of employees in the firm are associated with workplace learning activities experienced by employees.FindingsThis study found that organisation-related, individual-related and team-related drivers significantly influence workplace learning activities experienced by employees. In addition, employees’ age, firm-specific experience and the number of employees in the firm significantly influence the same.Originality/valueThis paper presents learning activities experienced by employees in the completion of work-related job tasks at hand and drivers experienced by employees in the new normal that has existed since the Covid-19 pandemic.
Unsettling colonial mentalities in family therapy: Entering negotiated spaces
Authors: Jordan Lorien S. 
Published: November 2021

AbstractThis article discusses the settler colonial roots of family therapy, positing that much of what is considered the standard or ideal family form comes from colonialism. Utilising settler colonial theory as a guide, I identify how the colonial nations, built through the violent exclusion of Indigenous and exogenous peoples, utilised the family to further their goals. Rather than suggest settler colonialism was an historic event, I consider how it continues today, privileging white families of European descent. To move the conversation forward on how white therapists from majoritised cultures can engage with racialised clients, I describe the negotiated spaces as a meeting ground where therapists and clients navigate differing worldviews. In these negotiations, our clients trust us, and to be accountable to this trust, we can unsettle the influence of settler colonialism. To conclude this paper, I discuss four possible pathways to begin the complicated process of unsettling.
Practitioner Points

Settler colonialism contributed to the standardisation of the nuclear family, informing the foundations of family therapy.

Establishing a ‘negotiated space’ in therapy can encourage ethical engagement between therapist and client as they navigate differences in culture, knowledge and meaning.

To ethically be in the negotiated spaces, therapists from majoritised cultures can ‘unsettle’ settler colonialism’s influence.

Learning personal and disciplinary relationships to settler colonialism, developing cultural humility and attending to power is the first step in unsettling.
Does Criminalizing Torture Deter Police Torture?
Authors: Berlin Mark S. 
Published: November 2021

AbstractMuch research casts doubt on the effectiveness of legal norms for improving respect for human rights. But such studies have mostly focused on treaty ratifications or constitutional provisions. In contrast, I focus on national criminal law. I argue that criminalization of torture is more likely to deter police torture than these other forms of legal prohibition, because criminalization more credibly increases the threat of material and social costs of torture, while also helping to catalyze mobilization that amplifies these deterrent effects. Using an original, global dataset on national criminal laws against torture, I find that states that criminalize torture and define it in line with the standards codified in the UN Convention against Torture experience reductions in police torture. These findings highlight a largely unexplored angle on the relationship between law and human rights protection and underscore the general importance of domestic legal internalization for the effectiveness of international law.
Complementary bottles during the first month and risk of cow’s milk allergy in breastfed infants
Authors: Garcette Karine , Hospital Véronique , Clerson Pierre , Maigret Pascal , Tounian Patrick 
Published: November 2021

AbstractAimTo assess the impact of complementary feeding bottles given at maternity hospital and/or over the first month after discharge from the maternity ward on cow's milk allergy (CMA) risk in breastfed infants.MethodsCase‐control study involving infants aged 6–9 months and who were breastfed for at least 1 month.ResultsIn 554 cases with a diagnosis of CMA and 211 controls, feeding bottles at maternity hospital, feeding bottles during the first month of life, avoidance of dairy products during pregnancy or breastfeeding, family history of allergy, intake of antibiotics and consumption of proton‐pump inhibitors or antacids by the infant during the first month of life were associated with increased risk of CMA in a univariate model. In a multivariate model, only feeding bottle at maternity hospital (OR = 1.81 [1.27; 2.59]), family history of allergy (OR = 2.83 [2.01; 3.99]) and avoidance of dairy products during pregnancy or breastfeeding (OR = 5.62 [1.99; 15.87]) were independent risk factors of CMA.ConclusionComplementary bottles given at maternity hospital to newborns who will be exclusively breastfed increases the later risk of CMA. Similarly, avoidance of dairy products during pregnancy or breastfeeding should be discouraged.
Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination
Authors: Myojin Yuta , Hikita Hayato , Tahata Yuki , Doi Akira , Kato Seiya , Sasaki Yoichi , Shirai Kumiko , Sakane Sadatsugu , Yamada Ryoko , Kodama Takahiro , Hagiwara Hideki , Imai Yasuharu , Hiramatsu Naoki , Tamura Shinji , Yamamoto Keiji , Ohkawa Kazuyoshi , Hijioka Taizo , Fukui Hiroyuki , Doi Yoshinori , Yamada Yukinori , Yakushijin Takayuki , Mita Eiji , Sakamori Ryotaro , Tatsumi Tomohide , Takehara Tetsuo 
Published: November 2021

SummaryBackgroundAfter hepatitis C virus (HCV) elimination, patients should be followed up due to risk of hepatocellular carcinoma (HCC). Growth differentiation factor 15 (GDF15) is a cytokine induced by mitochondrial dysfunction or oxidative stress.AimTo evaluate the prognostic value of GDF15 for HCC occurrence after HCV elimination.MethodsWe measured GDF15 levels in stored serum from patients with chronic HCV infection without a history of HCC who had achieved sustained virological response with direct‐acting antiviral agents (DAAs). The patients were randomly divided into derivation (n = 964) and validation (n = 642) cohorts.ResultsIn the derivation cohort, serum GDF15 levels were higher in those with HCC occurrence after DAA treatment than in those without. Multivariate Cox proportional hazards analysis revealed baseline GDF15 (>1350 pg/mL, HR 2.54), AFP (>5 ng/mL, HR 2.00), and the FIB‐4 index (>3.25, HR 2.69) to be independent risk factors for HCC. Scoring based on GDF15, AFP and the FIB‐4 index stratified HCC occurrence risk. In the validation cohort, the cumulative HCC occurrence rate at 3 years was 0.64%, 3.27% and 15.3% in low‐score (N = 171), medium‐score (N = 300) and high‐score (N = 166) groups, respectively. In the total cohort, scoring divided patients with a FIB‐4 index ≤3.25, whose HCC occurrence rate was 2.0% at 3 years, into medium‐score and low‐score groups with HCC occurrence rates at 3 years of 3.76% and 0.24%, respectively.ConclusionsSerum GDF15 predicts de novo HCC occurrence. Scoring using GDF15, AFP, and the FIB‐4 index can predict de novo HCC occurrence risk after HCV elimination.
Sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA2b) mediates oxidation‐induced endoplasmic reticulum stress to regulate neuropathic pain
Authors: Li Shaoheng , Zhao Fang , Tang Qinglian , Xi Chuchu , He Jing , Wang Yujing , Zhu Michael X. , Cao Zhengyu 
Published: November 2021

Background and PurposeNeuropathic pain is a widespread health problem with limited curative treatment. Decreased sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) expression has been reported in dorsal root ganglion (DRG) of animals suffering from neuropathic pain. We aimed to establish the relationship between SERCA expression and the pain responses and to elucidate the underlying molecular mechanism.Experimental ApproachNeuropathic pain was modelled using rat chronic constriction injury (CCI). Ca2+ imaging and current clamp patch‐clamp were used to determine cytosolic Ca2+ levels and action potential firing, respectively. Western blots, immunofluorescence staining and qRT‐PCR were used to quantitatively assess protein and mRNA expression, respectively. H&E staining and coupled enzyme assays were used to evaluate the nerve injury and SERCA2b activity, respectively.Key ResultsSERCA2b is the predominant SERCA isoform in rat DRG and its expression is decreased after CCI at mRNA, protein and activity levels. Whereas inhibiting SERCA with thapsigargin causes neuronal hyperexcitation, nerve injury, endoplasmic reticulum (ER) stress, satellite glial cell activation and mechanical allodynia, activating SERCA by CDN1163 or overexpressing SERCA2b in DRG after CCI produces long‐term relief of mechanical and thermal allodynia accompanied by morphological and functional restoration through alleviation of ER stress. Furthermore, the down‐regulation of DRG SERCA2b in CCI rats is caused by increased production of ROS through Sp1‐dependent transcriptional inhibition.Conclusion and ImplicationsOur findings reveal a novel pathway centring around SERCA2b as the key molecule underlying the mechanism of development and maintenance of neuropathic pain, and SERCA2b activators have the potential for therapeutic treatment of neuropathic pain.
Group I PAKs in myelin formation and repair of the central nervous system: what, when, and how
Authors: Wang Yan , Guo Fuzheng 
Published: November 2021

ABSTRACTp21‐activated kinases (PAKs) are a family of cell division control protein 42/ras‐related C3 botulinum toxin substrate 1 (Cdc42/Rac1)‐activated serine/threonine kinases. Group I PAKs (PAK1–3) have distinct activation mechanisms from group II PAKs (PAK4–6) and are the focus of this review. In transformed cancer cells, PAKs regulate a variety of cellular processes and molecular pathways which are also important for myelin formation and repair in the central nervous system (CNS). De novo mutations in group I PAKs are frequently seen in children with neurodevelopmental defects and white matter anomalies. Group I PAKs regulate virtually every aspect of neuronal development and function. Yet their functions in CNS myelination and remyelination remain incompletely defined. Herein, we highlight the current understanding of PAKs in regulating cellular and molecular pathways and discuss the status of PAK‐regulated pathways in oligodendrocyte development. We point out outstanding questions and future directions in the research field of group I PAKs and oligodendrocyte development.
Gradient boosting approaches can outperform logistic regression for risk prediction in cutaneous allergy
Authors: Cunningham Louise , Ganier Clarisse , Ferguson Felicity , White Ian R. , Watt Fiona M. , McFadden John , Lynch Magnus D. 
Published: November 2021

AbstractBackgroundContact allergy is a major clinical and public health challenge. It is important to identify individuals who are at risk and perform patch testing to identify relevant allergens. Predicting clinical risk on the basis of input parameters is common in clinical medicine and traditionally has been achieved with linear models.ObjectivesWe hypothesized that the risk of a clinically relevant positive patch test could be predicted according to clinical and demographic parameters.MethodsWe compared the predictive accuracy of logistic regression with more sophisticated machine learning approaches such as gradient boosting, in the prediction of patch testing results.ResultsWe found that both logistic regression and more sophisticated machine learning approaches were able to predict the risk of positive patch tests. For certain predictions, including the overall risk of a clinically relevant positive patch test, gradient boosting approaches can outperform logistic regression.ConclusionsThese findings suggest that complex nonlinear interactions between input variables are relevant in risk prediction. While a risk prediction model cannot replace the judgment of an experienced clinician, quantifying the risk of a clinically relevant positive patch test result has the potential to assist in decision making and to inform discussions with patients.