bluuebunny/crossref_metadata_2025_split huggingface dataset:
Male Sex Is Associated With Cervical Artery Dissection in Patients With Fibromuscular Dysplasia
Authors: Arnaud Charlotte , Boulanger Marion , Lorthioir Aurélien , Amar Laurence , Azarine Arshid , Boyer Louis , Chatellier Gilles , Di Monaco Silvia , Jeunemaitre Xavier , Kastler Adrian , Mousseaux Elie , Oppenheim Catherine , Thony Frédéric , Persu Alexandre , Olin Jeffrey W. , Azizi Michel , Touzé Emmanuel , Azarine Arshid , Azizi Michel , Chatellier Gilles , Chedid Antoine , Fiquet Béatrice , Jeunemaitre Xavier , Mousseaux Elie , Plouin Pierre‐François , Baguet Jean‐Philippe , Ormezzano Olivier , Thony Frédéric , Silhol François , Bodiguel Eric , Domigo Valérie , Oppenheim Catherine , Pasquini Marta , Touzé Emmanuel , Trystram Denis , Boyer Louis , Clavelou Pierre , Chamontin Bernard , Duly‐Bouhanick Béatrice , Hénon Hilde , Mounier‐Vehier Claire , Astarci Parla , Goffette Pierre , Hammer Frank , Lengelé Jean‐Philippe , Persu Alexandre , Severino Francesca , Verhelst Robert , Le Hello Claire , Gosse Philippe , Hervé Dominique , Pico Fernando , Kessler Michèle , Rossignol Patrick , Sanson Yves , Zuber Mathieu , Mazighi Mikael , Alamowitch Sonia 
Published: May 2021

Background
Cervical artery dissection (CeAD) is a frequent manifestation of fibromuscular dysplasia (FMD). However, risk factors for CeAD are unknown. We investigated factors associated with CeAD in the ARCADIA (Assessment of Renal and Cervical Artery Dysplasia) registry.

Methods and Results

The ARCADIA registry includes women or men aged ≥18 years, with a diagnosis of renal, cervical, or intracranial artery FMD, who were prospectively recruited at 16 university hospitals in France and Belgium. Diagnosis of acute or past CeAD at inclusion was established on imaging according to standard diagnostic criteria. Associations between potential determinants and CeAD were assessed by logistic regression analyses. Among 469 patients (75 men) with FMD, 65 (13.9%) had CeAD. Patients with CeAD were younger, more likely to be men, have a history of migraine, and less likely to have a history of hypertension than patients without CeAD. In the multivariable analysis, male sex (odds ratio [OR], 2.66; 95% CI, 1.34–5.25), history of migraine (OR, 1.90; 95% CI, 1.06–3.39), age ≥50 years (OR, 0.41; 95% CI, 0.23–0.73), history of hypertension (OR, 0.35; 95% CI, 0.20–0.64), and involvement of ≥3 vascular beds (OR, 2.49; 95% CI, 1.15–5.40) were significantly associated with CeAD. To validate the association between CeAD and sex, we performed a systematic review. We collected additional data on sex from 2 published studies and unpublished data from the US Registry for Fibromuscular Dysplasia and the European/International FMD Registry. In the pooled analysis (289 CeAD, 1933 patients), male sex was significantly associated with CeAD (OR, 2.04; 95% CI, 1.41–2.95;
I
2
=0%).

Conclusions
In patients with FMD, male sex and multisite involvement are associated with CeAD, in addition to other previously known risk factors.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02884141.
Transcatheter Device Closure of Perimembranous and Intracristal Ventricular Septal Defects in Children: Medium‐ and Long‐Term Results
Authors: Jiang Diandong , Han Bo , Zhao Lijian , Yi Yingchun , Zhang Jianjun , Fan Youfei , Lv Jianli , Wang Jing , Wang Yan 
Published: May 2021

Background
In children, the practice of transcatheter closure of intracristal ventricular septal defect (icVSD) has been limited. Currently, there is a lack of comparison between device closure of perimembranous ventricular septal defect (pmVSD) and icVSD, and long‐term clinical outcomes are rare.

Methods and Results

This study included a total of 633 children (39 with icVSD and 594 with pmVSD), aged 18 months to 16 years, who underwent transcatheter closure of ventricular septal defect between January 2014 and December 2018. All patients were followed up until September 2020, with a median follow‐up of 46 months in the pmVSD group and 52 months in the icVSD group. The procedural success rate was 96.3% and 84.6% in pmVSD and icVSD groups, respectively (
P
=0.002). The median of age, weight, procedure time, fluoroscopic time, and radiation dose were greater in the icVSD group compared with the pmVSD group. More eccentric ventricular septal defect occluders were used in the icVSD group. Most adverse events were minor without any intervention, with cardiac rhythm/conduction abnormalities being the most common. In the pmVSD group, 2 patients experienced complete atrioventricular block, with one implanting a permanent pacemaker and the other dying of cardiac arrest secondary to reversible complete atrioventricular block 40 days postprocedure. Complete left bundle‐branch block occurred in 14 patients, and 12 cases were transient. In the icVSD group, no complete atrioventricular block or death occurred, and one patient developed transient complete left bundle‐branch block.

Conclusions
In selected patients, transcatheter device closure of pmVSD and icVSD can be performed safely and successfully, with excellent medium‐ and long‐term results in children.
Association Between Uric Acid, Carotid Intima‐Media Thickness, and Cardiovascular Events: Prospective Results From the IMPROVE Study
Authors: Mannarino Massimo R. , Pirro Matteo , Gigante Bruna , Savonen Kai , Kurl Sudhir , Giral Philippe , Smit Andries , Veglia Fabrizio , Tremoli Elena , Baldassarre Damiano , Amato M. , Frigerio B. , Ravani A. , Sansaro D. , Coggi D. , Tedesco C. , Capra N. , Bonomi A. , Calabresi Laura , Sirtori C. R. , Eriksson Per , Silveira Angela , Leander Karin , Laguzzi Federica , Hamsten Anders , de Faire Ulf , Humphries Steve E. , Cooper J. , Acharya J. , Huttunen K. , Rauramaa E. , Penttila I. M. , Törrönen J. , van Gessel A. I. , van Roon A. M. , Nicolai A. , Mulder D. J. , Smeets G. H. , Kontush Anatole , Carrié Alain , Gallo Antonio , Karppi J. , Nurmi T. , Nyyssönen K. , Tuomainen T. P. , Tuomainen J. , Kauhanen J. , Vaudo G. , Bianconi V. , Siepi D. , Lupattelli G. 
Published: May 2021

Background
The association between elevated serum uric acid (SUA), cardiovascular disease (CVD) risk, and carotid atherosclerosis has long been explored, and contrasting results have been reported. Therefore, the role of SUA as an independent risk factor for vascular events (VEs) and carotid atherosclerosis deserves further attention. We investigated the relationship between SUA, incident VEs, carotid intima‐media thickness (cIMT), and cIMT progression in subjects at moderate‐to‐high CVD risk.

Methods and Results

In the IMPROVE (IMT‐Progression as Predictors of VEs) study, 3686 participants (median age 64 years; 48% men) with ≥ 3 vascular risk factors, free from VEs at baseline, were grouped according to SUA quartiles (division points: 244–284–328 µmol/L in women, 295–336–385 µmol/L in men). Carotid‐IMT and its 15‐month progression, along with incident VEs, were recorded. A U‐shaped association between SUA and VEs was observed in men, with 2.4‐fold (
P
= 0.004) and 2.5‐fold (
P
= 0.002) increased CVD risk in the first and fourth SUA quartiles as compared with the second. Adjusted hazard ratios (HRs) for cerebro‐VEs in men were the highest (first and fourth quartile versus second: HR, 5.3,
P
= 0.010 and HR, 4.4,
P
= 0.023, respectively). SUA level was independently associated with cIMT progression in men (β = 0.068,
P
= 0.014). No significant association between SUA levels, CVD end points, and cIMT progression were found in women.

Conclusions
Both low and high SUA levels are associated with an increased risk of VEs in men at moderate‐to‐high CVD risk but not in women. Only elevated SUA levels predict cIMT progression and at a lesser but not significant extent in women.
Diagnostic Thresholds for Pre–Diabetes Mellitus and Diabetes Mellitus and Subclinical Cardiac Disease in the General Population:
Data From the ACE 1950 Study
Authors: Myhre Peder L. , Lyngbakken Magnus N. , Berge Trygve , Røysland Ragnhild , Aagaard Erika N. , Pervez Osman , Kvisvik Brede , Brynildsen Jon , Norseth Jon , Tveit Arnljot , Steine Kjetil , Omland Torbjørn , Røsjø Helge 
Published: May 2021

Background
Diabetes mellitus (DM) is associated with left ventricular remodeling and incident heart failure, but the association between glycated hemoglobin A1c (HbA1c) and subclinical cardiac disease is not established. We aimed to determine the associations between HbA1c and (1) echocardiographic measures of left ventricular structure and function, and (2) cardiovascular biomarkers: cardiac troponin T, NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), and CRP (C‐reactive protein).

Methods and Results

Participants (n=3688) born in 1950 from the population‐based ACE (Akershus Cardiac Examination) 1950 Study were classified as DM (HbA1c≥6.5% or self‐reported DM), pre‐DM (HbA1c 5.7%–6.5%), and no‐DM (HbA1c<5.7%). DM, pre‐DM, and no‐DM were classified in 380 (10%), 1630 (44%), and 1678 (46%) participants, respectively. Mean age was 63.9±0.7 years, mean body mass index was 27.2±4.4 kg/m
2
, and 49% were women. Higher HbA1c was associated with worse left ventricular systolic (ejection fraction and global longitudinal strain) and diastolic (E/e'‐ratio) function, myocardial injury (cardiac troponin T), inflammation (CRP), and impaired neurohormonal homeostasis (NT‐proBNP) (
P
<0.001 in unadjusted and
P
<0.01 in adjusted analysis for all). The associations between HbA1c and cardiovascular biomarkers were independent of the echocardiographic variables, and vice versa. Associations were nonlinear (
P
<0.05 for nonlinearity) and appeared stronger in the pre‐DM range of HbA1c than the no‐DM and DM range.

Conclusions
HbA1c was associated with indexes of subclinical cardiovascular disease, and this was more pronounced in pre‐DM. Our results suggest that cardiovascular preventive measures should be considered also in subjects with hyperglycemia and HbA1c below the established DM cutoff.

Registration
clinicaltrials.gov. Identifier: NCT01555411.
Observed impact of meso-scale vertical motion on cloudiness
Authors: George Geet , Stevens Bjorn , Bony Sandrine , Klingebiel Marcus , Vogel Raphaela 
Published: May 2021

AbstractWe use estimates of meso-scale vertical velocity and co-located cloud measurements from the second Next-Generation Aircraft Remote Sensing for Validation campaign (NARVAL2) in the tropical North Atlantic to show the observed impact of meso-scale vertical motion on tropical clouds. Our results not only confirm previously untested hypotheses about the role of dynamics being non-negligible in determining cloudiness, but go further to show that at the meso-scale, the dynamics has a more dominant control on cloudiness variability than thermodynamics. A simple mass-flux estimate reveals that meso-scale vertical velocity at the sub-cloud layer top explains much of the variations in peak shallow cumulus cloud fraction. In contrast, we find that thermodynamic cloud-controlling factors, such as humidity and stability, are unable to explain the variations in cloudiness at the meso-scale. Thus, capturing the observed variability of cloudiness may require not only a consideration of thermodynamic factors, but also dynamic ones such as the meso-scale vertical velocity.
A multimodel investigation of atmospheric mechanisms for driving Arctic amplification in warmer climates
Authors: Dutta Deepashree , Sherwood Steven C. , Meissner Katrin J. , Sen Gupta Alex , Lunt Daniel J. , Tourte Gregory J. L. , Colman Robert , Narsey Sugata , Fuchs David , Brown Josephine R. 
Published: May 2021

AbstractWhen simulating past warm climates, such as the early Cretaceous and Paleogene periods, general circulation models (GCMs) underestimate the magnitude of warming in the Arctic. Additionally, model intercomparisons show a large spread in the magnitude of Arctic warming for these warmer-than-modern climates. Several mechanisms have been proposed to explain these disagreements, including the unrealistic representation of polar clouds or underestimated poleward heat transport in the models. This study provides an intercomparison of Arctic cloud and atmospheric heat transport (AHT) responses to strong imposed polar-amplified surface ocean warming across four atmosphere-only GCMs. All models simulate an increase in high clouds throughout the year; the resulting reduction in longwave radiation loss to space acts to support the imposed Arctic warming. The response of low and mid-level clouds varies considerably across the models, with models responding differently to surface warming and sea ice removal. The AHT is consistently weaker in the imposed warming experiments due to a large reduction in dry static energy transport that offsets a smaller increase in latent heat transport, thereby opposing the imposed surface warming. Our idealised polar amplification experiments require very large increases in implied ocean heat transport (OHT) to maintain steady state. Increased CO2 or tropical temperatures that likely characterised past warm climates, reduces the need for such large OHT increases.
Relative Contribution of Trend and Interannually Varying SST Anomalies to the 2018 Heat Waves in the Extratropical Northern Hemisphere
Authors: Hong Chi-Cherng , Tseng Wang-Ling , Hsu Huang-Hsiung , Lee Ming-Ying , Chang Chi-Chun 
Published: May 2021

AbstractThe northern extratropics—including regions in northern Europe, northeast Asia, and North America—experienced extremely prolonged heat waves during May–August 2018. Record-breaking surface temperatures, which caused numerous deaths, were observed in several cities. The 2018 heat waves exhibited a circumglobal characteristic owing to a circumpolar perturbation (CCP) in the middle–upper troposphere of the Northern Hemisphere (NH). The CCP had two parts: a wavelike perturbation and a hemispheric perturbation that was almost zonally symmetric. Singular-value decomposition analysis revealed that the zonally symmetric perturbation was coupled to the SST warming trend, whereas the wavelike perturbation was primarily coupled to the interannually varying SST anomaly (SSTA), particularly in the tropical North Pacific, which reached an extreme in 2018. Numerical experiments confirmed that the zonally symmetric component primarily resulted from the SSTA associated with the warming trend, whereas the interannually varying SSTAs in the NH contributed mostly to the wavelike perturbation. The warming trend component of SSTA, especially that in the tropics, compounded by the unusually large SSTAs in 2018, was hypothesized to have contributed to inducing the circumpolar circulation anomaly that caused the record-breaking heat waves in the extratropical NH in 2018.
Intensity of Poverty and Work Diversification: A Study of Female Domestic Workers’ Household
Authors: Bhattacharjee Sanghita , Goswami Bhaskar 
Published: May 2021

It is now a recognized fact that the earning from a single source does not provide a sufficient means of survival for a majority of poor households in developing countries. Accordingly, most of the poor households depend on a diverse portfolio of activities and income sources. This study is based on a primary survey of 334 female domestic workers in the district of South 24 Parganas, West Bengal, India from January to June 2016. The results of intensity of poverty show that 49% of these households are multi-dimensionally poor with 36.4% intensity of poverty. The severity and acuteness of deprivation is addressed by diversification into non-agricultural employment. The wage of the female domestic worker is not only an important determinant of livelihood strategy it is also a motivating factor for diversification. Large sections of the male workforce diversify into various non-farm activities such as manufacturing and construction in the secondary sector or hotel and restaurant, transport and so on in the services sector. Our findings reveal that diversification into non-farm informal sector is a vital option for livelihood sustenance irrespective of landless or land poor households. JEL Codes: J160, J460, J310, R23
The Effect of Antiosteoporosis Therapy With Risedronate on Rotator Cuff Healing in an Osteoporotic Rat Model
Authors: Xu Junjie , Su Wei , Chen Jiebo , Ye Zipeng , Wu Chenliang , Jiang Jia , Yan Xiaoyu , Cai Jiangyu , Zhao Jinzhong 
Published: May 2021

Background: Osteoporosis increases the revision rate of rotator cuff repair (RCR). Weak fixation might not be the only cause of high RCR failure rates. The biological mechanism associated with tendon-to-bone healing after RCR in osteoporosis should be investigated. Hypothesis: (1) Osteoporosis would impair rotator cuff healing through the high osteoclastic activity at the repaired interface. (2) Risedronate would promote rotator cuff healing by reducing osteoclastic activity at the repaired interface. Study Design: Controlled laboratory study. Methods: A total of 84 female Sprague Dawley rats were randomly treated using ovariectomy or sham surgeries to establish osteoporotic and nonosteoporotic rat models. After confirming osteoporosis, a chronic rotator cuff tear model was created and RCR was performed. Postoperatively, osteoporotic rats were randomly divided into osteoporosis (OP) and osteoporosis with risedronate administration (OP+RIS) groups. Nonosteoporotic rats were used as the control (CON) group. Osteoclastic activity was measured at 1 and 3 weeks after RCR, and histologic analysis of the tendon-to-bone interface, bone morphometric evaluation, and biomechanical tests were performed at 4 and 8 weeks. Results: At the early healing stages of 1 and 3 weeks after RCR, the OP group showed the highest osteoclast density at the repaired interface. Compared with the OP group, risedronate administration significantly decreased osteoclast density in the OP+RIS group. At 8 weeks, histologic scores were greater in the OP+RIS group than in the OP group but still lower than in the CON group. Histologic scores at 8 weeks were negatively correlated with osteoclast density at the early healing stage. Additionally, the OP+RIS group showed better bone morphometric parameters and biomechanical properties than did the OP group. Conclusion: Osteoporosis impaired rotator cuff healing, which might be related to the high osteoclast density at the repaired interface at the early healing stage. Postoperative risedronate administration decreased osteoclast density and enhanced rotator cuff healing in osteoporotic rats, although the effect was inferior to that in nonosteoporotic rats. Clinical Relevance: Postoperative risedronate administration can be considered a potential therapy to enhance rotator cuff healing in patients with postmenopausal osteoporosis. However, this needs to be verified in a clinical setting.
Minimum 5-Year Outcomes for Revision Hip Arthroscopy With a Prospective Subanalysis Against a Propensity-Matched Control Primary Group
Authors: Maldonado David R. , Kyin Cynthia , Rosinsky Philip J. , Shapira Jacob , Diulus Samantha C. , Lall Ajay C. , Domb Benjamin G. 
Published: May 2021

Background: There is a paucity of midterm outcome data on hip revision arthroscopic surgery. Purpose: (1) To report minimum 5-year patient-reported outcome measurement scores (PROMSs) in patients who underwent revision hip arthroscopy, (2) to compare minimum 5-year PROMSs with a propensity-matched control group that underwent primary hip arthroscopy, and (3) to compare the rate of achieving the minimal clinically important difference (MCID) at minimum 5-year follow-up between the revision group and the propensity-matched control primary group. Study Design: Cohort study; Level of evidence, 3. Methods: Data were prospectively collected between June 2008 and April 2014. Patients were included who underwent revision hip arthroscopy with preoperative and minimum 5-year follow-up scores for the modified Harris Hip Score (mHHS), Non-arthritic Hip Score (NAHS), Hip Outcome Score–Sports Specific Subscale (HOS-SSS), and visual analog scale (VAS) for pain. Patients with Tönnis grade >1 or with hip conditions such as avascular necrosis, Legg-Calve-Perthes disease, Ehlers-Danlos syndrome, and pigmented villonodular synovitis were excluded. A subanalysis was performed against a propensity-matched control group that underwent primary surgery. Groups were propensity matched in a 1:2 ratio for sex, age, body mass index, and follow-up time. Results: A total of 127 revision arthroscopies (113 patients) were included, and the mean ± SD follow-up time was 72.8 ± 23.3 months. The revision group was 74.0% female, and the average age and body mass index were 34.9 ± 12.4 years and 24.8 ± 4.2, respectively. The revision group demonstrated improvement for all PROMSs and reached the MCID for the mHHS (66.1%), HOS-SSS (68.4%), NAHS (66.9%), and VAS (80.0%). All revision cases were propensity matched to 254 primary arthroscopy cases. PROMSs in the revision group were lower than those of the control group before and after surgery. Delta values were similar between groups for all PROMSs. There were no differences in rates of achieving the MCID. The relative risk of arthroplasty conversion was 2.6 (95% CI, 1.5-4.6) for the revision group as compared with the primary group. Conclusion: Significant improvement in all PROMSs, including the VAS, and high patient satisfaction at minimum 5-year follow-up were reported after revision hip arthroscopy. A high proportion of patients in the revision cohort reached the MCID for the mHHS, HOS-SSS, NAHS, and VAS, with similar rates and magnitudes of improvement relative to the control group. As expected, these data indicate that patients undergoing primary hip arthroscopy have higher PROMSs before and after surgery and lower rates of conversion to arthroplasty.
The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma
Authors: Tanrıverdi Zübeyde , Meteroglu Fatih , Yüce Hande , Şenyiğit Abdurrahman , Işcan Mümtaz , Unüvar Songül 
Published: May 2021

Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group ( p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters ( p > 0.05) in the patient group. All biomarkers were positively correlated with each other ( p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.