bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Critical Role for YPK1 in Farnesol Mediated Modulation of Aureobasidin A Drug Susceptibility
Authors: Venkatramanan M , BARI VINAY KUMAR 
Published: October 2021

Abstract
Candida albicans is a dimorphic fungus, have the ability to secrete a quorum sensing molecule farnesol in a cell density dependent manner which regulates its morphogenic shift from yeast to hyphae. The ability to switch between different forms is highly correlated with its ability to cause disease such as Candidiasis. The switching between different yeast to hyphae form leads to significant alteration in the plasma membrane sphingolipids. Complex sphingolipids are principal components of fungal plasma membranes; and their interaction with antifungal drug can play a crucial role in multidrug resistance. Therefore, we reasoned that the farnesol mediated modulation of the complex sphingolipid biosynthetic pathway might lead to the altered drugs susceptibility. Our studies demonstrate for the first time that exogenous addition of farnesol affects the sphingolipid biosynthesis and causes altered Aureobasidin A (AbA) drug susceptibility which mainly inhibits the complex sphingolipid biosynthesis pathway.
The Impact of Quality Management Practices on Manufacturing Performance: An Empirical Study Based on System Theory
Authors: Liu Jie , Zhuang Dejuan , Shen Wei 
Published: October 2021

Abstract
As one important part of core competitiveness of manufacturing enterprises, quality management practices have gradually received more attention. In many existing researches, quality management practices are regarded as a whole or categorized into two or four types of practice elements for discussions. There are less researches on the relationships among specific quality management practice elements and their impacts on manufacturing performance. This study analyzes quality management practices with the philosophical thinking of system theory, and deconstructs the mechanism of the mutual influences and synergies among various quality management practice elements and also their impacts on manufacturing performance, from an overall perspective through an empirical research. At last, a model of quality management practice synergies is built, as a theoretical support for manufacturing enterprises implementation of quality management practices.
Relationship between the Height of Fibular Head and the Incidence and Severity of Knee Osteoarthritis
Authors: Xu Xinghui , Li Jun , Yao Deping , Deng Pan , Chen Boliang , Liu Yifei , jin Yang 
Published: October 2021

Abstract
Objective: To investigate the correlation between fibular head height and the incidence and severity of varus knee osteoarthritis based on three-dimensional reconstruction of the knee joint.Methods: The data of knee joint imaging in our hospital from June 2018 to June 2020 were collected. The degree of varus deformity of the knee was assessed at the superior hip-knee-ankle angle of the X-rays. Three-dimensional reconstruction of patient computed tomography(CT)data was performed by mimics software. The fibular head height, joint line convergence angle (JLCA) and medial proximal tibial angle (MPTA) were measured in a three-dimensional model. The patients were divided according to the Kellgren-Lawrence grade: group A: grade 0, group B: grade I, group C: grade II, group D: grade III, and group E: grade IV. The differences in age, gender, height, weight, body mass index(BMI), fibular head height, and degree of varus deformity (JLCA, MPTA, and coxa-knee-ankle angle) were compared. Ordinal multivariate logistic regression was used to analyze the correlation between fibular head height and Kellgren-Lawrence grade.Pearson correlation was used to analyze the correlation between fibular head height and Kellgren-Lawrence grade.Results: 232 patients (232 knees) were finally included in the study, with Kellgren-Lawrence grades of 28 in group A, 31 in group B, 49 in group C, 53 in group D, and 71 in group E. The differences in age, gender, height, body mass index, fibular head height, JLCA, MPTA, and hip-knee-ankle angle among the five groups were statistically significant (P < 0.05), and the differences in body weight were not statistically significant (P > 0.05). There were significant differences in fibular head height, JLCA, JLCA and hip-knee-ankle angle between different groups (P < 0.05). Furthermore, there were significant differences in JLCA and hip-knee-ankle angle (P < 0.05), and both JLCA and hip-knee-ankle angle increased with severe aggravation of Kellgren-Lawrence grade. Furthermore, both fibular head height and MPTA decreased as the Kellgren-Lawrence grade was severely aggravated. There was a significant negative correlation between Kellgren-Lawrence grade and fibular head height (r = -0.812, P < 0.001). Furthermore, there was a significant negative correlation between fibular head height and hip-knee-ankle angle (r = -0.7905, P < 0.001). When Kellgren-Lawrence grade III and IV knees were considered as disease, ROC curve analysis showed a cut-off value of 10.63 for fibular head height and an AUC of 0.872.Conclusion: The height of fibular head in patients with varus knee osteoarthritis is smaller than that in non-osteoarthritis patients. In addition to body mass index, fibular head height is a risk factor for the pathogenesis of varus knee osteoarthritis,the smaller the fibular head height, the more severe the severity of osteoarthritis and the more severe the degree of varus deformity.
LRP11-AS1 Promotes the Malignant Behavior of Triple Negative Breast Cancer Cells via the MiR-149-3p/NRP2 Axis
Authors: Li Peng , Zeng Yu , Chen Yudan , Huang Peng , Chen Xinchun , Zheng Weidong 
Published: October 2021

Abstract
Background: Breast cancer is the most commonly diagnosed cancer in women. Triple negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to the deficiency in drug-targetable receptors. LRP11-AS1, a newly identified oncogenic long noncoding RNA (lncRNA) was found to be significantly overexpressed in TNBC cells. The aim of this study is to investigate the malignant roles and the oncogenic mechanisms of LRP11-AS1 in TNBC. Methods: CCK-8, colony formation, transwell migration and transwell invasion assays were performed to study the functions of LRP11-AS1. Quantitative PCR and western blot were used to determine the gene expression. Bioinformatics analysis and dual-luciferase reporter assay were conducted to study lncRNA and miRNA interactions. Results: LRP11-AS1 was found to be significantly overexpressed in TNBC cells compared to the non-TNBC cells and normal mammary epithelial cells. Knockdown of LRP11-AS1 could inhibit the growth and metastasis of TNBC cells and regulate cell cycle. Mechanistically, LRP11-AS1 was found to act as a competing endogenous RNA (ceRNA) to sponge miR-149-3p. Silencing of LRP11-AS1 increased the expression of miR-149-3p and overexpression of miR-149-3p suppressed the expression of LRP11-AS1. Inhibition of miR-149-3p could reverse the anticancer effect of LRP11-AS1 deficiency in TNBC cells. Moreover, Neuropilin-2 (NRP2) was found to be the target of miR-149-3p. Rescue experiments revealed that NRP2 overexpression could rescue the anticancer effect of LRP11-AS1 deficiency in TNBC cells. Conclusion: LRP11-AS1 overexpressed in TNBC showed the oncogenic effects possibly by sponging miR-149-3p and regulating the miR-1493p/NRP2 axis, which indicated LRP11-AS1 as a potential diagnostic biomarker and therapeutic target in TNBC.
Air pollution Exposure And Mammographic Breast Density In Tehran, Iran
Authors: Eslami Bita , Alipour Sadaf , Omranipour Ramesh , Naddafi Kazem , Naghizadeh Mohammad Mehdi , Shamsipour Mansour , Aryan Arvin , Abedi Mahboubeh , Bayani Leila , Hassanvand Mohammad Sadegh 
Published: October 2021

Abstract
Background: Air pollution is one of the major public health challenges in many parts of the world possibly has an association with breast cancer. However, the mechanism is still unclear. This study aimed to find an association between exposure to six criteria ambient air pollutants (PM2.5, PM10, SO2, NO2, O3, and CO) and mammographic breast density (MBD), as one of the strongest predictors for developing breast cancer, in women living in Tehran, Iran.Methods: Participants were selected from women attending two university hospitals for screening mammography from 2019 to2021. Breast density was rated by two expert radiologists. Individual exposures to 3-years ambient air pollution levels at the residence were estimated.Results: The final analysis in 791 eligible women showed that low and high breast density was detected in 34.8% and 62.2% of participants, respectively. Logistic regression analysis after considering all possible confounding factors represented that an increase in 10 units of NO2 (ppb) exposure was associated with an increased risk of breast density with an OR equal to 1.47 (95% CI: 1.10 to 1.97). Furthermore, CO level was associated with a decreasing breast density (OR = 0.33, 95% CI = 0.17 to 0.64). None of the other pollutants were associated with breast density.Conclusion: MBD was associated with higher levels of ambient air NO2 and lower levels of CO. Perhaps MBD monitoring as an available tool in each population, can help the prediction of future breast cancer occurrence and finding the high-risk geographic areas.
Performance Analysis and Evaluation of Ternary Optical Computer Based on Asynchronous Multiple Vacations
Authors: Xianchao Wang , Xianchuan Wang , Jie Zhang , Man Ling , Dayou Hou , Kai Song 
Published: October 2021

Abstract
Ternary optical computer(TOC) has become a research hotspot in the field because of the advantages such as inherent parallelism, numerous trits, low power consumption, extendibility, bitwise allocability and dynamical bitwise reconfigurability. Meanwhile, its performance evaluation attracts more and more attentions from potential users and researchers. To model its computing ecology more accurately, this paper first builds a three-staged TOC service model by introducing asynchronous multi-vacations and tandem queueing, and then proposes a task scheduling algorithm and an optical processor allocation algorithm with asynchronous vacations of some small optical processors after dividing equally the entire optical processor into several small optical processors which can be used independently. At the same time, the analytical model was established to obtain important performance indicators such as response time, the number of tasks and utilization of optical processor, based on M/M/1 and M/M/n queuing system with asynchronous multi-vacations. In addition, relevant numerical simulation experiments are conducted. The results illustrate that the number of small optical processors, vacation rate and the number of small optical processors allowed to be on vacation have important effects on the system performance. Compared with synchronous vacation, asynchronous vacation not only ensures the system to obtain better maintenance but also improves the system performance to some degree.
The added value of recent-infection testing in population-based HIV surveys
Authors: Mhlanga Laurette , Grebe Eduard , Welte Alex 
Published: October 2021

Abstract
Background: There is no clear consensus on how best to use increasingly available data derived from large populationbased surveys featuring HIV infection status ascertainment. In particular, for the purpose of estimating HIV incidence, there is considerable scope for better elucidation of the benefit of adding ‘recent infection’ ascertainment, which adds considerable additional cost and complexity to surveys which are already costly and complex. Methods: Using an epidemic/survey simulation tool developed for this and some closely related investigations, we explore the value added by ‘recent infection’ data from population surveys, to support HIV incidence estimation. This directly piggy-backs on to two companion pieces which have explored, independently, the use of the ‘synthetic cohort’ paradigm of Mahiane et al (analysing age/time structure of prevalence, in conjunction with estimates of mortality) and the paradigm of Kassanjee et al (focusing on ‘recent infection’ data). Results: Our headline findings are that: 1) Recent infection data adds marginal benefit to surveillance focused on the early years after sexual debut, which can reasonably be taken to be a core sentinel group in which surveillance is significantly more efficient than attempts to cover all ages; and 2) by contrast, recent infection data is crucial for the reliable estimation of incidence trends when only two cross sectional surveys are available. We detail numerous components of a general and robust approach to analysing data when both the Mahiane and Kassanjee analyses are in play. Conclusion: Our main results present non-trivial dilemmas for survey design, as recency data is crucial for stabilising the more timely estimates, but of marginal benefit for the most important sentinel group. We hope that adaptation of our analysis, to simulated scenarios closely aligned to specific contexts facing expensive choices, will support rational investments in, and use of, precious surveillance opportunities and data sets.
Antibacterial data synthesis challenges: a systematic review of treatments for complicated Gram-negative urinary tract infections
Authors: Dillon Ryan , Uyei Jennifer , Singh Rajpal , McCann Eilish 
Published: October 2021

Aim:
To determine the suitability of network meta-analysis (NMA) using antibacterial treatment evidence in complicated urinary tract infection.
Materials & methods:
We conducted a systematic literature review to identify published clinical trial data for complicated urinary tract infection treatments. We performed a feasibility assessment to determine whether the available evidence would support the creation of a robust NMA, considering key assumptions of homogeneity, similarity and consistency.
Results:
Twenty-five trials met eligibility criteria. Risk of bias was low, and individual studies met their primary end point(s). Assumptions central to the conduct of a robust NMA were not met. Heterogeneity was ubiquitous, including baseline pathogen, treatment and patient characteristics.
Conclusion:
Limited and heterogeneous data identified make the use of NMA to compare novel antibacterial agents impractical and likely unreliable.
Procedural Safeguards under the European Convention on Human Rights in Public (Administrative) Law Matters
Authors: Sever Tina 
Published: October 2021

AbstractThe effectiveness of procedure is important for parties (e.g. citizens or business entities) to be able to exercise their rights in due time and is a key foundation of the rule of law. A State with an effective legal system provides a business-friendly environment, which is appealing for investments. The State decides on permits, licenses, taxes, etc. by applying administrative procedure. The aim of the paper is to identify and analyse such matters under public (administrative) law at the national level, which – due to their influence on private rights or obligations – fall under the civil or criminal limb of Article 6 of the ECHR and its requirements, as well as the requirements of Article 13. By means of a case study and descriptive-analytical and normative methods, the paper identifies comparatively selected cases and analyses the ECtHR test regarding reasonable time, focusing on overall procedure duration and the awarded compensations. The findings show that the ECtHR does not define reasonable timein abstracto. Therefore, the established violations among the states range from two-year procedures to nine years and more, depending on the circumstances of each individual case. Similarly, there are also variations in terms of compensation awarded.
Assessment of National Program of Learning Regions in Slovakia – Design and Testing
Authors: Kološta Stanislav , Sabelová Lenka , Kráľ Pavol 
Published: October 2021

Abstract
In May 2007, the Ministry of Education, Science, Research and Sport of the Slovak Republic approved the National Program for Learning Regions. It states that the long-term strategic objective for the development of Slovak regions is the gradual reduction of disparities in living standards in regions and to improve regional economic performance. One of the tools for achieving this goal is considered the learning region concept. The main aim of this article is to streamline the presentation and monitoring of the partial progress made in achieving the objectives of the National Program for Learning Regions in the Slovak Republic to policy-makers and to make this relatively complex issue accessible to a wider audience through one aggregated index and two partial indices; the PCA method was used. The results showed relatively large differences between regions. The highest value of the aggregated LR index was reached by the Trnava region, followed by the Bratislava region; these two regions seems to be in accordance with reaching the objectives of the National Program for Learning Regions. The lowest values were found in the Banská Bystrica, Prešov and Košice regions. Moreover, we found a positive correlation between aggregated and economical-innovative indices with average GDP during the years 2008–2014 at the NUTS 3 level.
Potentials of Administrative Procedures as a Participatory Tool within Governance Models in Central and Eastern Europe
Authors: Kovac Polonca 
Published: October 2021

AbstractGood public governance requires participative networking to tackle the worst societal problems. Redefined administrative procedure as an instrument that should ensure efficient public policies is one of the key approaches in this respect. The objective of this article is to show, based on qualitative research methods, that in modern public administration, procedure is attributed a much different role than under the traditionalRechtsstaatdoctrine. It has been evolving towards becoming a dialogue tool for the state and the citizens, increasingly recognised in Neo-Weberian and good governance models, also in Central and Eastern Europe (CEE). Administrative procedure’s modernised codification in CEE countries, grounded in public administration theory, EU and case law, is in this article seen as of the utmost importance to apply in the region to develop its governance capacity. The article addresses said issues and provides a specific outline as to how to systematically and proportionally codify administrative procedural law in this sense on a national scale. The author proposes a concrete, holistic outline to redefine respective codification within contemporary public governance models. This outline incorporates minimum joint fundamental principles, e.g. the right to be heard. Following the principle of proportionality, in addition a more detailed codification is suggested by more formalised proceedings in the case of the collision of legally protected interests. The principles, such as participation, would apply for any administrative acts, resulting from legislative policy-making or single-case decision-making, and judicial reviews thereof alike. Such an approach should ensure a balanced recognition and effective protection of parties and public interest.
International Court Jurisdiction in Disputes Concerning Unlawful Use of Trademarks on the Internet
Authors: Gongol Tomáš , Zahradníková Radka 
Published: October 2021

Abstract
The rapid development of IT technologies in the last few decades has also created increasing number of cross-border disputes. This trend is affected by the fact, that there are no border lines that we can find in the real world. Different law systems have to deal with the existence of this new, on state borders independent entity. In the perspective of law, internet is interesting because of its inability as a virtual space, to fit in the doctrine of legal state, by which the state exercises its authority and enforces its law on its territory. This traditional bond between the state, its territory and its law system is impaired, sometimes it is referred to as virtualization or delocalization of legal relationships. Delocalization has a great influence on determination of the decisive law system and court jurisdictions. In those cases, we need to distinguish substantive law and procedural law in order to determine court (or other institution) jurisdiction and law system which would be applied on the case. With regard to the topic of this article, we will deal with private law relationships with international elements. Unlawful use of trademarks on the internet raises a number of issues. One example is the use of trademarks on the internet and to what extent such use is infringing trademark rights on a specific territory. This paper deals particularly with the jurisdictional issues and how rules on private international law can assist in resolving these issues. The currently applicable EU Brussels I Regulation (Recast) allows infringers to be sued either in the place of the defendant’s domicile or in the place of the harmful event.
Loan to Value Ratio and Monetary Transmission Mechanism
Authors: Reichel Vlastimil , Němec Daniel , Chalmovianský Jakub 
Published: October 2021

Abstract
Using a dynamic stochastic general equilibrium model (DSGE) with the housing sector, this paper evaluates the impact of housing collateral on the business cycle in the Czech economy. We devote special attention to the setting of the loan to value (LTV) ratio, which we believe plays an important role as a regulator of the monetary transmission mechanism. The impacts of LTV ratio are quantified by simulating the responses of alternative LTV level setting on key macroeconomic variables. Our simulations are based on an estimated DSGE model. Our approach allows us to understand better the responses of the real economy to the tightening of monetary policy moderated by different LTV levels. Our results show that higher loan to value ratios strengthen the effect of the monetary transmission mechanism to consumption and output.
Jurisdiction Not to Tax, Tax Sparing Clauses, and the OECD Minimum Taxation (GloBE) Proposal
Authors: Navarro Aitor 
Published: October 2021

AbstractThe OECD Programme of Work on the tax challenges arising from the digitalization of the economy comprises a so-called GloBE (Global Base Erosion) or Pillar Two proposal, consisting of a series of measures aimed at establishing a floor to tax competition by achieving minimum taxation of the income obtained by in-scope multinational enterprises. If such a measure is implemented, developing countries would be severely deprived of the possibility to grant tax incentives to attract FDI and potentially foster economic growth. This contribution emphasizes the importance of the thorough review of their tax policy preferences that developing countries should undertake amidst the rapid adoption of GloBE, which the OECD is pushing to achieve. To illustrate this concern, an examination of implementation issues shows that a deficient enactment of the income inclusion rule proposed in GloBE could paradoxically trigger the applicability of tax sparing clauses aimed at protecting the effectiveness of tax incentives, even when both sets of rules pursue opposing goals.
A Fenomenologia e o desafio do Naturalismo
Authors: Zahavi Dan 
Published: October 2021

Abstract
Whereas 20 or 30 years ago one might have been inclined to characterize the development of 20th century philosophy in terms of a linguistic turn, a turn from a philosophy of subjectivity to a philosophy of language, it might today be more apt to describe the development in terms of a turn from anti-naturalism to naturalism. But insofar as naturalists consider the scientific account of reality authoritative, a commitment to naturalism is bound to put pressure on the idea that philosophy can make a distinct and autonomous contribution to the study of reality. In the following, I will discuss the question of how phenomenology ought to respond to this challenge. What sense can we make of recent proposals to naturalize phenomenology?