bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Surrogate Enzyme-Linked Immunosorbent Assay to Select High-Titer Human Convalescent Plasma for Treating Immunocompromised Patients Infected With Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern
Authors: Dolange Victoria , Slamanig Stefan , Abdeljawad Adam , Lai Tsoi Ying , Lemus Nicholas , Singh Gagandeep , Carreño Juan Manuel , Abbad Anass , Srivastava Komal , Simon Viviana , Sachithanandham Jaiprasath , Pekosz Andrew , Sullivan David , Krammer Florian , Sun Weina , Palese Peter , González-Domínguez Irene 
Published: January 2025

Abstract

Background
The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants challenges the treatment of immunocompromised patients against coronavirus disease 2019 (COVID-19). High-titer COVID-19 convalescent plasma (CCP) remains one of the few available therapeutics for these patients. We have revisited the selection of CCP samples and evaluated their efficacy against the Omicron XBB.1.5 variant, the dominant strain in 2023.

Methods
A surrogate enzyme-linked immunoassay was reviewed to select CCP samples that ensure a protective level of neutralizing antibodies as the main correlate of protection. Antibody titers were analyzed in 500 serum samples from a population-based serosurvey at Mount Sinai Hospital in early 2023, and the results were validated with CCP samples (collected in 2020–2023) using an immunosuppressed mouse model.

Results
Using logistic regression modeling, we have redefined high-titer CCP against the new variant in the postpandemic era, where over 97% of the population has natural or vaccine-induced antibodies against earlier SARS-CoV-2 strains. Treatment of immunocompromised mice with two doses (100 μL/dose) of CCP plasma via intraperitoneal injection reduced lung viral titers by 46-fold 3 days post-XBB.1.5 infection.

Conclusions
These findings will guide future efforts in selecting high-titer CCP for emerging SARS-CoV-2 variants.
Emergence and Global Spread of Mpox Clade Ib: Challenges and the Role of Wastewater and Environmental Surveillance
Authors: Tiwari Ananda , Kalonji Thierry , Miller Taru , Van Den Bossche Tim , Krolicka Adriana , Muhindo-Mavoko Hypolite , Mitashi Patrick , Tahita Marc Christian , Lood Rolf , Pitkänen Tarja , Maketa Vivi 
Published: January 2025

Abstract
Several African countries, mainly the Democratic Republic of Congo, Burundi, and Uganda, are facing highly transmissible mpox clade Ib epidemics, prompting the World Health Organization to declare a Public Health Emergency of International Concern. It has spread to key travel hubs like Kinshasa, Bujumbura, and Kampala, increasing international spread risks. Current mitigation efforts focus mainly on medical care, diagnostics, vaccination, and infection prevention, but overlook wastewater and environmental surveillance (WES). WES can be effective in detecting hotspots and enabling rapid response through enhanced data collection and genomic sequencing. This perspective article reviews the latest outbreak situation and advocates integrating WES into response strategies.
Taking Peace into Our Own Hands: Colombian Feminists Use Local Politics to Advance Their Agenda for Peace
Authors: Fal-Dutra Santos Agnieszka , Cardona Sonia , Jaramillo Piedrahita Francy L 
Published: January 2025

Abstract
Feminist activism was a key force that shaped the peace negotiations between the Colombian government and Fuerzas Armadas Revolucionarias de Colombia—Ejercito Popular and the resulting 2016 peace agreement. Their efforts have resulted in a historic agreement that includes over 120 provisions related to issues of gender equality. However, as they advance a vision of sustainable and gender-equal peace, Colombian feminists have also faced a host of challenges. Important commitments made at the national level—for example, through the 2016 peace agreement or the recently drafted National Action Plan on Women, Peace, and Security—are often not translated to the local level, where gender inequality and different forms of insecurities faced by women remain rampant. In this article, the three coauthors build on their lived experiences of advancing the feminist agenda in Cauca, Colombia, to map out the ways in which Colombian feminists respond to the challenges they face. Bringing together a feminist institutionalist perspective with the norm localization framework, we trace how Colombian feminists have appropriated, adapted, and used global norms to influence local institutions through three processes: localization of the Women, Peace, and Security agenda; drafting of Local Development Plans; and the development of municipal Public Policy for Women in Puerto Tejada. We argue that norm localization can be effectively used as a strategy to influence institutions and gender dynamics within them. This adds to the ongoing discussions around the different strategies feminists can use to navigate in and change male-dominated and masculinized institutions.
Rethinking Failure: Feminist Peacebuilding and the Peace Continuum in Violent and Illiberal “Post-Conflict” Settings
Authors: Anderson Miriam J , Corredor Elizabeth S , Zulver Julia 
Published: January 2025

Abstract
This article introduces the special forum, “Feminism in the Face of Failure: Peacebuilding in Violent and Illiberal ‘Post-Conflict Settings,'” by exploring feminist responses to the shortcomings of both liberal and illiberal peacebuilding models in fragile post-conflict environments. We introduce the concept of a “peace continuum,” challenging traditional binary approaches to peace and conflict. Our framework highlights how grassroots feminist activists, often excluded from formal peace processes, persist in their peacebuilding efforts even amidst renewed violence, authoritarianism, and failed peace agreements. Drawing on examples from countries such as Colombia, Afghanistan, and Myanmar, the forum showcases how women are leading nonmilitarized, inclusive, and locally grounded peace efforts despite the collapse of formal peace processes. The articles collectively emphasize the resilience, intentionality, and ongoing activism of women in reshaping peace, advocating for gender equality, and addressing structural violence in their societies. The issue calls for broader recognition and support for these crucial, often overlooked, feminist peacebuilding efforts, even in situations deemed “failures.”
Survey of Laboratory Stewardship Governance at US Academic Medical Centers
Authors: Eby Charles S , Al-Hammadi Noor , Dodds Kathy , Sunkavalli Deepak , Gronowski Ann M 
Published: January 2025

Abstract

Background
Efforts to appropriately utilize laboratory tests have been underway for several decades. However, limited information is available regarding the status of laboratory stewardship at academic medical centers. Prior to initiating a laboratory stewardship committee, a study was initiated to gain insights from peer institutions.

Methods
An online REDCap survey was created and emailed to US pathology department leaders at 94 academic medical centers.

Results
Response rate was 40%. Sixty-eight percent (n = 26) of respondents indicated that they have a laboratory stewardship committee. There was variability among academic medical institutions regarding governance, committee structure and responsibilities, and assessment of laboratory stewardship committee performance. There was consensus for inclusion of: hospital administration and clinical leadership; informatics (IT) support, and a multidisciplinary clinical team combined with laboratory medicine expertise. Of the 32% (n = 12) without a committee, 4 started one but found it unsustainable, and 6 were unsuccessful at starting a program. Respondents without a current laboratory stewardship program cited lack of leadership support, insufficient management and IT resources, and unclear vision and goals as major factors. Fifty-eight percent of those without a laboratory stewardship committee predicted their hospital would establish one within the next 5 years.

Conclusions
Survey results provide insights into the status of laboratory stewardship efforts at peer institutions. Awareness of the structural and leadership components critical to successful and sustained initiatives will improve the quality and value of clinical laboratory services.
Analysis of modern strategies for using artificial intelligence technologies in the creation of fantasy content
Authors: Sultan Yertay , Dautova Gulnaz , Alkebayeva Dina , Akzhigitova Akkibat , Aden Zhansaya 
Published: January 2025

Abstract
This study explores the integration of artificial intelligence (AI) in the creation of fantasy narratives, examining the new possibilities AI offers for authors and readers and its impact on the genre’s evolution. The study used literature review, textual analysis, comparative analysis, data analysis, experimental methods, ethical and legal examination, and data processing methods using Natural Language Processing software. Through analysis of films, video games, and qualitative text review, the research found that modern technologies—particularly AI and computer graphics—have greatly enhanced the visualization of fantasy worlds, contributing to the genre’s growing popularity. Interactive AI-driven platforms enable customized experiences, increasing engagement and satisfaction among audiences. A significant finding is that contemporary fantasy works, while retaining traditional elements like the struggle between good and evil, magic, and adventure, are now incorporating modern socio-cultural and political themes. This blend preserves the genre’s appeal to diverse audiences while keeping it relevant in today’s context. Additionally, AI opens new avenues for authors by aiding in overcoming creative blocks, generating fresh ideas, and constructing interactive worlds where readers can shape the plot or create their own characters. This not only accelerates the creative process but also enriches storytelling with more varied narratives. The study concludes that fantasy remains a powerful tool for cultural and social expression and that AI holds great potential for the genre's future growth, promising more innovative and inclusive experiences for audiences.
How welfare and credit regimes shape economic policies during times of crisis: the case of Covid-19
Authors: Laprise Marie-Lou , Wiedemann Andreas 
Published: January 2025

Abstract
How much economic support governments offered to households during the Covid-19 pandemic differed considerably across rich democracies. What explains this variation? We argue that institutional structures of welfare and credit regimes shape households’ abilities to address income shortfalls and, as a result, governments’ policy repertoire during crises. In countries with permissive credit regimes, economic support policies were more comprehensive when social policies were limited. Governments not only provided income support but also debt relief to shield households from default risks due to high pre-crisis debt leverage. Yet those countries ceased income support sooner as credit resumed its substitutive role vis-à-vis the welfare state. We provide evidence for our argument by examining pandemic policies from five OECD countries that vary in their social policies, credit access and household indebtedness. Our findings suggest that the privatization of risks imposes financial burdens on households that constrain governments’ policy responses in times of crisis.
The value of crypto? Sociotechnical imaginaries on cryptocurrency in YouTube content
Authors: De Keere Kobe , Trans Martin , Milan Stefania 
Published: January 2025

Abstract
In less than two decades, cryptocurrency has transformed from being an object of interest for an obscure online community to becoming a digital asset of global appeal. By acknowledging the importance of fictional expectations in the creation of economic value, this study addresses the question: How is the value of crypto imagined? Through quantitative and qualitative coding of 1921 YouTube video transcripts, combined with Exploratory Factor Analysis, this article maps out the sociotechnical imaginaries that attribute value to crypto, that are being disseminated on YouTube. This study identifies four distinct imaginaries that project a value on cryptocurrency: investment, utility, digital metallism, and infrastructural mutualism imaginary. This explorative analysis sheds light on the potential value consumers attribute to cryptocurrencies while opening new research avenues toward a better understanding of the market and its mediation by platform algorithms as potential market devices.
Byers v Saudi National Bank: circumventing the knowing receipt doctrine
Authors: Arvidsson Christopher 
Published: January 2025

Abstract
This article will map a category of unconscionable transfers that can circumvent the knowing receipt doctrine by design. It exposes and charts these transfers—herein referred to as Samba Transfers—by looking at Byers v Saudi National Bank. While Byers is the model case, Samba Transfers can occur in many situations. The Supreme Court’s decision in Byers has paved the way for this category of unconscionable transfers. This is because the court dealt with the ‘knowing receipt issue’ by resorting to reasons of principle rather than focusing on the defendant’s unconscionable behaviour. This article endorses the Supreme Court’s principled approach. Still, it asks whether Samba Transfers are a cause for concern following Byers. In particular, can the law on dishonest assistance come to the rescue if a recipient of assets has used the judgment in Byers as a blueprint to evade liability in knowing receipt?
Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Authors: Guo Xiaoqing , Seo Ji-Eun , Xu Hannah , Yan Jian , Malhi Pritpal , Atrakchi Aisar H , McGovern Timothy , Davis Bruno Karen L , Heflich Robert H , Chen Tao 
Published: January 2025

Abstract
Several potent carcinogenic nitrosamines, including N-nitrosodiethylamine (NDEA) and N-nitrosodimethylamine (NDMA), induce micronuclei in the micronucleated hepatocyte (MNHEP) assay but not in the micronucleated reticulocyte (MNRET) assay. However, the MNHEP assay is not as frequently used as the MNRET assay for evaluating in vivo genotoxicity. The present study evaluated MN formation in the liver of Big Blue transgenic rats exposed to 4 small-molecule nitrosamines, NDMA, N-nitrosodiisopropylamine (NDIPA), N-nitrosoethylisopropylamine (NEIPA), and N-nitrosomethylphenylamine (NMPA), using a repeat-dose protocol typically used for in vivo mutagenicity studies. NDMA is a potent liver carcinogen, whereas NDIPA and NEIPA are relatively weak liver carcinogens, and NMPA primarily produces esophageal tumors. Seven-week-old rats were treated with the nitrosamines for 28 consecutive days; liver was harvested 3 days after the last dose and used for conducting the flow-cytometry-based MNHEP assay. All 4 nitrosamines induced dose-dependent increases in %MNHEP and the magnitude of the responses correlated with their carcinogenicity in rat liver. These results indicate that the flow-cytometry-based MNHEP assay can be successfully integrated into 28-day repeat-dose studies, and that the MNHEP assay may be useful for evaluating the genotoxicity of nitrosamines that have different carcinogenic potencies and different tumor target specificities.
Overcoming the snakebite challenge in Sudan: a call to action
Authors: Badri Rawa , Dawood Iyas , Osman Rana , Ahmed Nayyrah , Adam Salma Ibrahim Mohammed 
Published: January 2025

Abstract
Snakebite envenomation is a neglected tropical disease that affects millions of people in sub-Saharan Africa, including Sudan. The severity of snakebite envenomation ranges from mild to severe, and can even lead to death. Sudan has a high burden of snakebite envenomation, with an estimated 12 632 cases and a mortality rate of 2.5% per year. The country faces several challenges in addressing snakebite envenomation, including a weak health system, limited access to healthcare facilities and a shortage of antivenom. This article highlights the challenges facing snakebite control in Sudan and provides recommendations for reducing the burden of this neglected tropical disease.
National Action Plan for the prevention and control of snakebite envenoming in India: strategies and challenges
Authors: Munshi Hrishikesh , Gajbhiye Rahul K 
Published: January 2025

Abstract
India accounts for one-half of global snakebite-related deaths. The recently launched National Action Plan for the Prevention and Control of Snakebite Envenoming in India is a comprehensive initiative designed to address this burden. It aims to ensure universal access to antivenom, strengthen healthcare systems, train healthcare professionals and engage traditional healers to enhance public awareness. The plan also promotes democratization and inter-sectoral collaboration, allowing states to customize their approaches, and advocates for a One Health strategy. While the plan reinforces India's commitment to sustainable development, continued political commitment, robust monitoring and evaluation, global collaborations and community ownership remain crucial for its effective implementation.
Community-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda
Authors: Ediriweera Dileepa Senajith , Hakizimana Dieudonne , Diggle Peter J , Schurer Janna M 
Published: January 2025

Abstract

Background
Snakebite envenoming is a medical emergency that requires rapid access to essential medicines and well-trained personnel. In resource-poor countries, mapping snakebite incidence can help policymakers to make evidence-based decisions for resource prioritisation. This study aimed to characterise the spatial variation in snakebite risk, and in particular to identify areas of relatively high and low risk, in Eastern Province, Rwanda.

Methods
Snakebite surveillance of people bitten in 2020 was conducted in Eastern Province through household visits and case verification. Geostatistical modelling and predictive mapping were applied to data from 617 villages in six districts to develop sector-level and district-level risk maps.

Results
There were 1217 individuals bitten by snakes across six districts. The estimated population-weighted snakebite incidence in Eastern Province was 440 (95% predictive interval 421 to 460) cases per 100 000 people, corresponding to 13 500 (95% predictive interval 12 950 to 14 150) snakebite events per year. Two sectors in the southwest, Gashanda and Jarama, showed &gt;1500 snakebite events per 100 000 annually. The lowest incidence was observed in the north.

Conclusions
Considerable differences exist in snakebite risk between sectors in Eastern Province, with the highest risk concentrated in the southwest. Policymakers should consider prioritising resources related to snakebite prevention, essential medicines and health worker training in this region.
Genetic variability in snake venom and its implications for antivenom development in sub-Saharan Africa
Authors: Ayesiga Innocent , Okoro Lenz N , Taremba Chirigo , Yeboah Michael O , Naab Justine T M , Anyango Ruphline M , Adekeye John , Kahwa Ivan 
Published: January 2025

Abstract
Snake venom, a complex mixture of proteins, has attracted human attention for centuries due to its associated mortality, morbidity and other therapeutic properties. In sub-Saharan Africa (SSA), where snakebites pose a significant health risk, understanding the genetic variability of snake venoms is crucial for developing effective antivenoms. The wide geographic distribution of venomous snake species in SSA countries demonstrates the need to develop specific and broad antivenoms. However, the development of broad antivenoms has been hindered by different factors, such as antivenom cross-reactivity and polygenic paratopes. While specific antivenoms have been hindered by the numerous snake species across the SSA region, current antivenoms, such as SAIMR polyvalent and Premium Serums & Vaccines, exhibit varying degrees of cross-reactivity. Such ability to cross-react enables the antivenoms to target multiple components from the different snake species. The advent of biotechnological innovations, including recombinant antibodies, small-molecule drugs, monoclonal antibodies and synthetic antivenoms, presents options for eliminating limitations associated with traditional plasma-derived antivenoms. However, challenges still persist, especially in SSA, in addressing genetic variability, as evidenced by inadequate testing capacity and limited genomic research facilities. This comprehensive review explores the genetic variability of snake venoms in SSA, emphasizing the venom composition of various snake species and their interactions. This information is critical in developing multiple strategies during antivenom development. Finally, it offers information concerning the need for extensive collaborative engagements, technological advancements and comprehensive genomic evaluations to produce targeted and effective antivenoms.
Conflict between sea snakes and humans on the coast of West Bengal and Odisha, India: perception, attitudes and incidents
Authors: Patra Anweshan , Mahapatra Ardhendu Das , Malhotra Anita , Santra Vishal , Ghorai Sudipta Kumar , Annadurai D 
Published: January 2025

Abstract

Background
Snakebite envenoming is a critical medical emergency and significant global public health issue, with India experiencing the highest annual snakebite deaths. Sea snakes in the Indian Ocean pose a severe threat to rural fishermen due to their potent neurotoxins.

Methods
From December 2020 to December 2021, we conducted surveys at 15 fishing ports in East Medinipur, West Bengal, and Balasore, Odisha, India (between 21.805651 N 87.874188 E and 21.574851 N 87.374059 E). We interviewed 2301 fishermen in 421 group sessions to document sea snake bite incidents, outcomes and perceptions from 2012 onwards. Historical data were also retrieved from various databases and social media platforms.

Results
We recorded 166 sea snake bite cases, with 55.4% fatalities, 2.4% permanent disabilities and 41% survivors. Gill net fishermen were the most affected, with most bites occurring while handling snakes caught in nets, particularly at dawn and dusk. Fishermen reported a significant decline in sea snake populations over the past decade due to by-catch and killing practices.

Conclusions
Sea snake bites are a major occupational hazard for Indian fishermen, with high fatality rates due to limited medical access. Increased awareness, safer handling practices and improved medical infrastructure are essential to reduce mortality and conserve sea snake populations. This study highlights the need for targeted interventions in affected communities.