bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice Characteristics of Pediatric Otolaryngology Same-Day Appointments
Authors: Berg Jenna , Tu Alexander , Jones Dwight , Geelan-Hansen Katie 
Published: December 2021

Objectives This study aims to assess characteristics of same-day clinic appointments in a pediatric population at an academic otolaryngology practice. Methods Retrospective chart review of patients aged 18 or younger who had same-day clinic appointments between January 1, 2016, and December 31, 2018, at a single academic institution. Demographic data, diagnosis(es), procedures, and operations completed were included in the analysis. Results There were 363 same-day visits by 322 patients in the 3-year study period. Two hundred sixty-nine (269) of these visits were from new patients. Otitis media and rhinosinusitis were the most frequently coded diagnoses. One hundred forty-four (144) procedures were completed the day of the visit and 169 operations were performed as a result of the same-day visit. If the patient had a procedure or operation performed, they were more likely to have been referred by another provider. Conclusions Providing same-day appointments can help provide timely and appropriate otolaryngology specialty care to pediatric patients. Further evaluation is needed to determine the effects on patient satisfaction as well as no-show rates.
Bone metastases with post-treatment intralesional fatty content of the spine: imaging features from T1-weighted imaging with CT finding correlations
Authors: Park Sekyoung , Huh Jin Do 
Published: December 2021

Background Despite post-treatment intralesional fatty content (PIFAT) in bone metastases indicating a healing processes after treatment, the imaging features of PIFAT have not been studied in detail. Purpose To analyze imaging features from T1-weighted (T1W) imaging with computed tomography (CT) finding correlations in bone metastases with PIFAT of the spine. Material and Methods A total of 29 bone metastases with PIFAT were analyzed with T1W and CT images before and after treatment. On T1W imaging after treatment, the lesions were categorized into three types according to fat distribution patterns. CT attenuation changes after treatment were also evaluated. According to the MD Anderson (MDA) criteria, response types for all lesions were obtained on magnetic resonance (MR) and CT images. Results The types from T1W imaging in bone metastases with PIFAT were as follows: 14 with a return to totally normal marrow signal intensity within the lesion; 13 with an inhomogeneous patchy pattern in the lesion; and two with a peripheral halo of fatty marrow or peripheral fat signal intensity foci in the lesion. Among bone metastases with PIFAT, 93.1% showed osteosclerotic changes in this study. According to the MDA criteria, the concordance between the response types of the MR and CT images was 57.2%. Conclusion Knowledge of imaging features from T1W imaging with CT correlation in bone metastases with PIFAT is important for the accurate interpretation of post-treatment MR and CT studies. Both MR and CT images have a complementary value regarding the post-treatment evaluation of bone metastases with PIFAT.
Melting heat analysis in squeezed flow of nanofluids (SWCNTs + Water, SWCNTs + Gasoline oil, MWCNTs  + Water, MWCNTs + Gasoline oil) with Cattaneo–Cristov heat flux
Authors: Muhammad K. , Hayat T. , Alsaedi A. 
Published: December 2021

Abstract This analysis emphasizes impacts of CNTs (Carbon nanotubes) during Darcy–Forchheimer squeezed flow. Melting heat transfer process is addressed. Water and gasoline are treated as baseliquid. By transformation method non-linear system of ODEs are obtained from the flow field equations (PDEs). Further the emerged flow problem is solved via OHAM. Influences of physical involved parameters on velocity, surface friction coefficient, temperature as well as Nusselt number are expressed graphically and interpreted physically.
Charting a global research strategy for progressive MS—An international progressive MS Alliance proposal
Authors: Thompson Alan J , Carroll William , Ciccarelli Olga , Comi Giancarlo , Cross Anne , Donnelly Alexis , Feinstein Anthony , Fox Robert J , Helme Anne , Hohlfeld Reinhard , Hyde Robert , Kanellis Pamela , Landsman Douglas , Lubetzki Catherine , Marrie Ruth Ann , Morahan Julia , Montalban Xavier , Musch Bruno , Rawlings Sarah , Salvetti Marco , Sellebjerg Finn , Sincock Caroline , Smith Kathryn E , Strum Jon , Zaratin Paola , Coetzee Timothy 
Published: December 2021

Background: Progressive forms of multiple sclerosis (MS) affect more than 1 million individuals globally. Recent approvals of ocrelizumab for primary progressive MS and siponimod for active secondary progressive MS have opened the therapeutic door, though results from early trials of neuroprotective agents have been mixed. The recent introduction of the term ‘active’ secondary progressive MS into the therapeutic lexicon has introduced potential confusion to disease description and thereby clinical management. Objective: This paper reviews recent progress, highlights continued knowledge and proposes, on behalf of the International Progressive MS Alliance, a global research strategy for progressive MS. Methods: Literature searches of PubMed between 2015 and May, 2021 were conducted using the search terms “progressive multiple sclerosis”, “primary progressive multiple sclerosis”, “secondary progressive MS”. Proposed strategies were developed through a series of in-person and virtual meetings of the International Progressive MS Alliance Scientific Steering Committee. Results: Sustaining and accelerating progress will require greater understanding of underlying mechanisms, identification of potential therapeutic targets, biomarker discovery and validation, and conduct of clinical trials with improved trial design. Encouraging developments in symptomatic and rehabilitative interventions are starting to address ongoing challenges experienced by people with progressive MS. Conclusion: We need to manage these challenges and realise the opportunities in the context of a global research strategy, which will improve quality of life for people with progressive MS.
Carpal tunnel syndrome and finger deformities in children with mucopolysaccharidoses and mucolipidoses: a retrospective review of 52 patients
Authors: Thirache Clément , Gaume Mathilde , Gitiaux Cyril , Salon Arielle , Dana Caroline , Pannier Stéphanie 
Published: December 2021

This single-centre retrospective study reports our management of carpal tunnel syndrome in 52 children (103 hands) with mucopolysaccharidoses and mucolipidoses. All except one were bilateral. The median age at surgery was 4 years (range 1.5 to 12). The diagnosis of carpal tunnel syndrome was confirmed by an electromyogram (EMG) in all patients; 38% of these presented without any clinical signs. Surgical neurolysis was performed in all hands, combined with epineurotomy in 52 hands (50%) and flexor tenosynovectomy in 75 hands (73%). Surgery was bilateral in 98% of children (102 hands). The mean follow-up was 12 years (range 1 to 19) and the EMG was normalized in 78% of hands. Ten patients suffered recurrence, eight of whom required further surgery. Screening for carpal tunnel syndrome is essential for the management of children mucopolysaccharidoses and mucolipidoses. Surgical treatment should be carried out early with follow-up by EMG to detect recurrence. Level of evidence: IV
Curcumin suppresses neuroinflammation to protect neurons by preventing NLRP3 inflammasome activation
Authors: Shi Qiang , Zheng Ying-ying , Wang Le , Xue Yi-dong , Yang Yan-ling 
Published: December 2021

Introduction Nucleotide-binding and oligomerization domain like receptors protein 3 (NLRP3) inflammasome-mediated interleukin (IL)-1β secretion plays an important role in the progression of Alzheimer’s disease (AD). Curcumin has been shown to improve cognitive impairment and learning ability of AD mice by reducing IL-1β secretion. However, its exact mechanism of action remains unclear. In the present study, we explored the relationship between the neuroprotective effect of curcumin and activation of the NLRP3 inflammasome pathway. Methods BV2 cells were primed with 500 ng/mL lipopolysaccharide (LPS) for 4 h and subsequently treated with 50 μM Aβ25-35 for 24 h or pretreated with 2.5–10 μM curcumin for 4 h and exposed to 50 μM Aβ25-35 for 24 h. The effects of curcumin and Aβ25-35 were assessed by the CCK8 assay. ELISA was used for the detection of IL-1β, IL-6, and tumor necrosis factor (TNF)-α levels in the supernatant of the cell culture medium. The viability of SH-SY5Y cells, which were incubated with conditioned medium (CM) was assessed using the CCK8 assay. The percentage of apoptotic SH-SY5Y cells incubated with CM was assessed using Annexin V-FITC/PI staining flow cytometry analysis. The expression levels of NLRP3, caspase-1 and IL-1β were observed by western blot and immunofluorescence staining analyses; the mRNA levels of nlrp3, caspase-1 and IL-1β were analyzed using qRT-PCR. Results Low (2.5 μM), medium (5 μM), and high (10 μM) concentrations of curcumin and 50 μM Aβ25-35 were used to perform the experiments in the present study. Curcumin attenuated the IL-1β, IL-6, and TNF-α release and increased SH-SY5Y cell activity, while decreasing the apoptotic percentage of SH-SY5Y cells using Aβ25-35 for cell stimulation ( p < 0.05). Furthermore, curcumin inhibited the expression of NLRP3, caspase-1 and IL-1β and nlrp3 in BV-2 cells ( p < 0.05), However, curcumin did not affect the expression levels of caspase-1 and IL-1β ( p > 0.05) Conclusion Overall, the data indicated that curcumin is a promising neuroprotective agent for suppressing neuroinflammation by inhibiting the NLRP3 inflammasome pathway.
Examining the Effect of Short-Term Affect on Farmers’ Risk and Time Preferences in Financial Decision-Making
Authors: Begho Toritseju , Ambali Omotuyole I. 
Published: December 2021

Farmers regularly make intertemporal decisions under risk or uncertainty. To improve how farmers behave when faced with decisions that have financial consequences, there is a need for a deeper understanding of farmers’ risk and time preferences. While the relationship between individual components of affect and risk preferences is well documented, the same cannot be said for holistic measures of affect on one hand, and for affect and time preferences on the other hand. The data analysed in this paper is the 2014–2015 Indonesian Family Life Survey Wave 5. The survey included experimental measures designed to elicit both risk and time preferences from the same subjects. We analysed the data using limited dependent variable regression models. Our findings strengthen what is known about the affect infusion model. With increased pleasant affect, farmers’ willingness to take risks increases significantly. The results also suggest that pleasant affect is associated with increased odds that farmers will choose future rewards in the long horizon but had no statistically significant effect on the short horizon. The practical implications are that an experience of pleasant affect before decision-making may cause the decision-maker (DM) to perceive a prospect as having high benefits and low risks. Pleasant affect may also induce lower sensitivity towards losses and play the role of a buffer which reduces the immediate negative impact of information that otherwise would prevent the DM from focusing on the long-term. JEL Classifications: C93, D81, D91
Determining the Efficiency of Ergonomic Belt During Patient Handling and its Effect on Reducing Musculoskeletal Disorders in Nurses
Authors: Zakerian Seyed Abolfazl , Afzalinejhad Mansooreh , Mahmodi Mahmood , Sheibani Niloofar 
Published: December 2021

Introduction Nursing personnel are always at risk for work-related musculoskeletal disorders, and patient transportation is one of the major risk factor for these disorders. Objective The aim of this study was to evaluate the ergonomic belt to improve patient transferring conditions. Methods The subjects included 60 health care workers (HCW) of a hospital with patient transfer experience. The ergonomic belt was examined to help move the patient from one bed to another. The prevalence of musculoskeletal disorders was assessed through the Nordic questionnaire, the degree of perceived exertion through the Borg criterion, and the patient's movement through the MAPO index before and after the intervention. Results The results showed a significant decrease in Borg scale scores and MAPO index in two factors of education and auxiliary tools and overall scores of this index. We also saw a significant reduction in musculoskeletal disorders in the neck, shoulders and arms, waist, hands and wrists, thighs, knees and legs. There were no significant differences in the elbow and forearm before and after using the ergonomic belt. Conclusion In general, it can be concluded that the use of ergonomic belt had helped to reduce the risk of musculoskeletal disorders, as well as reducing the perceived exertion of nurses and other relevant personnel.
Linguistic Movements and Political Heterogeneity: Rethinking Unification Movement across British and ‘Princely’ Karnataka
Authors: Boratti Vijayakumar M. 
Published: December 2021

Subsequent to the Partition of Bengal in 1905, the consolidation of linguistic identities and movements emerged as an important assertion of core democratic values, positing that governance must be in a language intelligible to the majority. Like other linguistic movements in late-colonial India, the Karnataka Ekikarana (Karnataka unification) movement did not proceed with a spatially uniform logic nor followed a uniform temporality in realising its objectives of uniting Kannada speakers from disparate sub-regions. Attempting to reconcile elite literary ambitions, popular aspirations and political differences, the movement shifted gears through several phases as it worked across multiple territorial jurisdictions and political systems, including the demarcations of British India and princely India. Focussing on the period between 1860 and 1938, the present article examines the heterogeneous nature of the unification movement across British-Karnataka and two Kannada-speaking princely states, namely, Mysore in the south and Jamakhandi in the north. It explores the ways in which the ruling family of ‘model’ Mysore sought legitimacy in embracing their Kannada heritage; in contrast, the Jamakhandi rulers resisted any concession to Kannada linguistic sentiments. The article shows how, in arriving at monolingually indexed territorial entities, the bridging of ‘internal’ frontiers across these divergent political and linguistic contours proved just as crucial as the claiming of dominance over other language groups within an intensely polyglot world.
Effect of hypoxic conditioning on functional fitness, balance and fear of falling in healthy older adults: a randomized controlled trial
Authors: Timon Rafael , Camacho-Cardeñosa Marta , González-Custodio Adrián , Olcina Guillermo , Gusi Narcis , Camacho-Cardeñosa Alba 
Published: December 2021

Abstract
Background
Hypoxic conditioning has been proposed as a new tool to mitigate the sarcopenia and enhance health-related function, but decrements in standing balance have been observed during hypoxia exposure. The aim of the study was to evaluate the effect of a hypoxic conditioning training on functional fitness, balance and fear of falling in healthy older adults.

Methods
A total of 54 healthy older adults (aged 65–75 years), who voluntarily participated in the study, were randomly divided into three groups: the control group (CON), the normoxia training group (NT) that performed strength training in normoxia, and the hypoxia training group (HT) that trained under moderate hypoxic conditions at a simulated altitude of 2500 m asl. The training programme that was performed during 24 weeks was similar in both experimental groups and consisted of a full-body workout with elastic bands and kettlebells (three sets × 12–15 reps). The Senior Fitness Test (SFT), the Single Leg Stance test (SLS) and the Short Falls Efficacy Scale-International (FES-I) were assessed before and after the intervention.

Results
Results showed that after training, either in normoxia or in hypoxia, the participants increased upper and lower body strength, and the aerobic endurance, and decreased the fear of falling.

Conclusions
The moderate hypoxic conditioning seems to be a useful tool to increase the functional capacity in healthy older adults without observing a decline in balance.

Trial registration
ClinicalTrials.gov NCT04281264. Registered February 9, 2019-Retrospectively registered.
Investigation of hub gene associated with the infection of Staphylococcus aureus via weighted gene co-expression network analysis
Authors: Li Jia-xin , Cao Xun-jie , Huang Yuan-yi , Li Ya-ping , Yu Zi-yuan , Lin Min , Li Qiu-ying , Chen Ji-chun , Guo Xu-guang 
Published: December 2021

Abstract
Introduction
Staphylococcus aureus is a gram-positive bacterium that causes serious infection. With the increasing resistance of bacteria to current antibiotics, it is necessary to learn more about the molecular mechanism and cellular pathways involved in the Staphylococcus aureus infection.

Methods
We downloaded the GSE33341 dataset from the GEO database and applied the weighted gene co-expression network analysis (WGCNA), from which we obtained some critical modules. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) were applied to illustrate the biological functions of genes in these modules. We constructed the protein-protein interaction (PPI) network by Cytoscape and selected five candidate hub genes. Five potential hub genes were validated in GSE30119 by GraphPad Prism 8.0. The diagnostic values of these genes were calculated and present in the ROC curve based on the GSE13670 dataset. Their gene functions were analyzed by Gene Set Enrichment Analysis (GSEA).

Results
A co-expression network was built with 5000 genes divided into 11 modules. The genes in green and turquoise modules demonstrated a high correlation. According to the KEGG and GO analyses, genes in the green module were closely related to ubiquitination and autophagy. Subsequently, we picked out the top five hub genes in the green module. And UBB was determined as the hub gene in the GSE30119 dataset. The expression level of UBB, ASB, and MKRN1 could significantly differentiate between Staphylococcus aureus infection and healthy controls based on the ROC curve. The GSEA analysis indicated that lower expression levels of UBB were associated with the P53 signal pathway.

Conclusions
We identified some hub genes and significant signal enrichment pathways in Staphylococcus aureus infection via bioinformatics analysis, which may facilitate the development of potential clinical therapeutic strategies.
Comparative evaluation of pain perception with a new needle-free system and dental needle method in children: a randomized clinical trial
Authors: Altan Halenur , Belevcikli Melek , Coşgun Alem , Demir Osman 
Published: December 2021

Abstract
Background
Pain control during dental procedures is one of the most important topics related to behavior management in children. This study aims to compare the pain perception associated with a needle-free system (Comfort-In™) and the dental needle method during filling and pulpotomy treatments in children.

Methods
The study included teeth that required treatment (pulpotomy or filling treatment) in 56 patients aged 4 to 11 years with no systemic problems or history of allergy. Patients were randomly divided into the needle-free system group (filling treatment, n = 13; pulpotomy, n = 15) and dental needle method group (filling treatment, n = 14; pulpotomy, n = 14). For pulpotomy and filling treatment performed with 0.3 mL anesthesia, the active ingredient of which is 2% lidocaine and 1/80000 epinephrine. The patients’ behavior before the procedure was evaluated by a pediatric dentist using the Frankl Behavior Scale. The pain intensity was assessed Immediately after injection (induction), during treatment (treatment), and at the end of the treatment (post treatment) by the Wong-Baker Faces Pain Scale.

Results
The median (IQR-InterQuartile Range) induction pain value was 6[3-8] and 2[0-4] in dental needle method and needle-free system respectively, p < 0.001). In filling and pulpotomy treatment group, no difference between the needle and needle-free group for treatment and post-treatment pain values.

Conclusions
For pulpotomy and filling treatment, needle-free system performed with 0.3 mL anesthesia was found as effective as infiltrative anesthesia with a dental needle method.

Trial registration
ClinicalTrials.gov, NCT04653974. Registered 4 December 2020 – Retrospectively registered.
A conceptual analysis of older adults’ empowerment in contemporary japanese culture
Authors: Tsubouchi Yoshihito , Yorozuya Kyosuke , Tainosyo Akiyoshi , Naito Yasuo 
Published: December 2021

Abstract
Background
Empowerment among older adults is a key concept for improving their health. In contrast, empowerment evolves according to cultural and historical contexts and needs to be consistently tested and constructed. The purpose of this study was to clarify the components of older adults’ empowerment in contemporary Japan and to reconstruct the definition of empowerment.

Methods
A conceptual analysis was performed using Rodgers’ evolutionary method. The data sources were PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Cochrane Library, and Igaku Chuo Zasshi. The search keywords were “empowerment,” “older adults,” and “Japan/Japanese.” Of the 8811 articles published between 2000 and 2019 that focused on older adults’ empowerment, we selected 60 articles that met our objectives.

Results
Seven antecedents, six attributes, and seven consequences were identified. Older adults’ empowerment in contemporary Japan was defined as “the series of processes in which disclosing oneself, not only verbally but also nonverbally (e.g., through work, roles, and collaborative activities), in connection with others, objectively perceiving one’s existence and challenges, taking proactive actions based on decision-making, and utilizing one’s strengths in new work and community life.”

Conclusions
This concept is useful in practice, education, and research on community development and providing support for older adults based on self-help and mutual aid, not only in Japan but also for the global aging society.