bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KEMAMPUAN TANAH DI DAERAH PEMUKIMAN KOTA BENGKULU DALAM MENJERAP ALKYL BENZENE SULPHONATE (ABS) DAN LINEAR ALKYLBENZENE SULPHONATE (LAS)
Authors: Ananda Fikri , Candra I Nyoman , Elvinawati Elvinawati 
Published: July 2021

This research aims to know the ability of land in a residential area of the city of Bengkulu in adsorbed Alkyl Benzene Sulphonate (ABS) and Linear Alkyl Benzene Sulphonate (LAS). Soil samples were taken at five-point i.e. the backyard of Balai Buntar, Fatmawati Airport, Beringin Raya , Pematang Gubernur and Simpang Nakau with a drill ground at a depth of 20 cm and cleaned from garbage impurity. Then the soil characterized include moisture content, pH, texture and the organic content and ABS and ALS adsorbsition measured using UV-vis spectrophotometers att 222-223 nm wavelengths. In this research tested the influence of pH, pulp and optimum contact time contacts from soil sample at in ABS and ALS adsorbsition The adsorbtion pattern is known as the Freundlich and Langmuir parameters. Based on research, generally, it can be concluded that the land in the residential area of Bengkulu city has characteristic average water content – average 23%, pH average – average 5.35 and it's Turn dusty clay. The optimum condition from soil in adsorbs from Alkyl Benzene Sulphonate (ABS) occurs at pH 3, a mass of 1 g and 2 hours of contact time with the adsorption capacity of 0.874 mg/g, while for Linear Alkyl Benzene Sulphonate (LAS) adsorption the optimum soil conditions occur at pH 2, mass 0.5 g and 1-hour contact time with the adsorption capacity of 1.607 mg/g. The pattern of soil adsorption against ABS tends to follow the Langmuir equation whereas against LAS tend to follow the Freundlich equation. Adsorpstion of soil samples in Bengkulu City against ABS belongs to low and adsorpstion against LAS belongs to very low
PEMBUATAN NANOPARTIKEL-PERAK EKSTRAK DAUN UBI JALAR ORANGE (Ipomoea batatas L.) DENGAN METODE BIOREDUKSI DAN UJI AKTIVITAS TERHADAP JUMLAH TROMBOSIT Mus musculus
Authors: Trinanda Ririn , Sundaryono Agus , Handayani Dewi 
Published: July 2021

This study aims to make silver nanoparticles (NPP) of orange Sweet potato extract (Ipomoea batatas L.) using bioreduction method and test the effect of giving silver nanoparticles - leaf extract of Ipomoea batatas L. orange (Ipomoea batatas L.) to the number of thrombocyte from male of Mus musculus induced by aspirin. The precursor used is 1 mM AgNO3 solution and as bioreductor is an antioxidant compound in orange sweet potato extract (Ipomoea batatas L.). The ratio of AgNO3 1 mM solution volume and orange sweet potato leaf extract is 9: 1 with 2 hours time. The characteristic test again obtained NPP is done using FTIR and Particle Size Analyzer (PSA) using Dynamyc Light Scattering method (DLS). The results showed that from the PSA analysis is known the average size of NPP – I. Batatas, L leaf extract is an average of 86.0 nm with a polydispersity value (PDI) of 0.17 < 1 that indicates that the NPP-leaf extract particle size distribution It is less homogeneous and are less stable.The results show that the administration of silver nanoparticles - orange sweet potato extract (Ipomoea batatas L.) can increase the platelet count of male mice significantly Dose of 0.014 g / Kgbb of 259,600 / mm3.
PENERAPAN MODEL PEMBELAJARAN AUDITORY, INTELLECTUALY DAN REPETITION (AIR) DENGAN MENGGUNAKAN MEDIA PEMBELAJARAN KARTU ARISAN UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR SISWA KELAS X MIA 1 SMAN 8 KOTA BENGKULU
Authors: Sumiati Diana , Bahar Amrul , Handayani Dewi 
Published: July 2021

This study aimed to improve learning activities and learning outcomes of students in class X MIA 1 of Senior High School (SMAN) 8 Bengkulu on the subject of chemical bonds through the application of Auditory, Intellectualy, and Repetition (AIR) learning models by using learning media with lottery card. This study is a classroom action research consisting of three cycles, each cycle consisting of four stages, planning, action, observation and reflection. In collection of data was done by non-test and test methods, teacher observation sheets, student observation sheets and post-test. The data was processed by using simple quantitative data analysis techniques, the total value of each student, the average value, the percentage of absorptive power, learning completeness and the average observation score.The results of the study in the 2018/2019 school year showed that the application of the Auditory Intellectualy Repitition learning model using learning media with lottery cards in class X MIA 1 of SMA Negeri 8 Kota Bengkulu could improve teacher activities, student activities and student chemistry learning outcomes. This can be seen from the average score of teacher activities in the first cycle to the third cycle in a row : 23, 27.5 and 31.5. Student activity also showed improvement in each cycle. The average score of student activity in cycle I to cycle III was sequentially 20, 25 29.5. Learning outcomes also increase in each cycle. This can be seen from the average value of the test results in each cycle, in the first cycle of 61.82, in the second cycle of 67.88, in the third cycle of 79.09. Classical absorption in cycle I, cycle II, cycle III are 61.82%, 67.88%, 79.09%, with the percentage of completeness learning in each cycle of 42%, 73%, and 87.8 %.
PERBANDINGAN MODEL PEMBELAJARAN PROBLEM SOLVING DAN PROBLEM BASED LEARNING TERHADAP KEMAMPUAN BERPIKIR KRITIS SISWA KELAS XI MIA MAN 2 KOTA BENGKULU
Authors: Sani Ida Nurjelita , Bahar Amrul , Elvinawati Elvinawati 
Published: July 2021

The aim of this study to determine the comparison of Problem Solving (PS) and Problem Based Learning (PBL) models to critical thinking skills of student on buffer solution material. This type of research is quasi experimental research with posttest only control group design research design. The population of this study is all class XI IPA of MAN 2 Bengkulu City academic year 2018/2019 as many 133 students. The analysis of the data was used the normality test, homogeneity test, and hypothesis test. The research sample was taken by purposive sampling technique. Data on the results of students' critical thinking skills are obtained from the value of the posttest or final test. Posttest is done by using test instruments in the form of descriptive tests as many as 6 items, each of which has a different critical thinking indicator. Previous test instruments were tested and analyzed to see the level of validity, reliability, differentiation and the level of difficulty of the questions. The results of the study showed that the average value of students' critical thinking ability achievement in the experimental class 1 was higher than that of the experimental class 2 students which were 74.09 and 70.22. Based on these results, the experimental class 1 which applied the problem solving learning model was better at improving students' thinking skills than the experimental class 2 which applied a problem-based learning model. Hypothesis testing with the T-test at the 0.05 significance level yields a sig value. (2-tailed)> level of signicant which is 0.147> 0.05 so that Ho is accepted. Thus, it can be concluded that there is no significant difference between the critical thinking skills of the experimental class 1 students who apply PS models and experimental class 2 students who apply the PBL model.
Artificial Intelligence-Aided Recognition of Pathological Characteristics and Subtype Classification of Superficial Perivascular Dermatitis
Authors: Bao Yingqiu , Zhang Jing , Zhang Qiuli , Chang Jianmin , Lu Di , Fu Yu 
Published: July 2021

Background: Superficial perivascular dermatitis, an important type of inflammatory dermatosis, comprises various skin diseases, which are difficult to distinguish by clinical manifestations and need pathological imaging observation. Coupled with its complex pathological characteristics, the subtype classification depends to a great extent on dermatopathologists. There is an urgent need to develop an efficient approach to recognize the pathological characteristics and classify the subtypes of superficial perivascular dermatitis.Methods: 3,954 pathological images (4 × and 10 ×) of three subtypes—psoriasiform, spongiotic and interface—of superficial perivascular dermatitis were captured from 327 cases diagnosed both clinically and pathologically. The control group comprised 1,337 pathological images of 85 normal skin tissue slides taken from the edge of benign epidermal cysts. First, senior dermatologists and dermatopathologists followed the structure–pattern analysis method to label the pathological characteristics that significantly contribute to classifying different subtypes on 4 × and 10 × images. A cascaded deep learning algorithm framework was then proposed to establish pixel-level pathological characteristics' masks and classify the subtypes by supervised learning.Results: 13 different pathological characteristics were recognized, and the accuracy of subtype classification was 85.24%. In contrast, the accuracy of the subtype classification model without recognition was 71.35%.Conclusion: Our cascaded deep learning model used small samples to deliver efficient recognition of pathological characteristics and subtype classification simultaneously. Moreover, the proposed method could be applied to both microscopic images and digital scanned images.
Analytic and Integrative Framework for Understanding Human Sympathetic Arterial Baroreflex Function: Equilibrium Diagram of Arterial Pressure and Plasma Norepinephrine Level
Authors: Yamasaki Fumiyasu , Sato Takayuki , Sato Kyoko , Diedrich André 
Published: July 2021

BackgroundThe sympathetic arterial baroreflex is a closed-loop feedback system for stabilizing arterial pressure (AP). Identification of unique functions of the closed system in humans is a challenge. Here we propose an analytic and integrative framework for identifying a static operating point and open-loop gain to characterize sympathetic arterial baroreflex in humans.Methods and ResultsAn equilibrium diagram with two crossing functions of mechanoneural (MN) and neuromechanical (NM) arcs was analyzed during graded tilt maneuvers in seven healthy subjects. AP and plasma norepinephrine level (PNE), as a surrogate for sympathetic nerve activity, and were recorded after vagal modulation of heart function was blocked by atropine. The MN-arc curve was described as a locus of operating points during –7, 0, 15, and 60° head-up tilting (HUT) on a PNE-AP plane. The NM-arc curve was drawn as a line between operating points before and after ganglionic blockade (trimethaphan, 0.1 mg⋅ml–1⋅kg–1) during 0° or 15° HUT. Gain values were estimated from the slopes of these functional curves. Finally, an open-loop gain, which is a most important index for performance of arterial baroreflex, was given by a product of the gain values of MN (GMN) and NM arcs (GNM). Gain values of MN was 8.92 ± 3.07 pg⋅ml−1⋅mmHg−1; and GNM at 0° and 15° HUT were 0.61 ± 0.08 and 0.36 ± 0.05 mmHg⋅ml⋅pg–1, respectively. A postural change from supine to 15° HUT significantly reduced the open-loop gain from 5.62 ± 0.98 to 3.75 ± 0.62. The effects of HUT on the NM arc and open-loop gain seemed to be similar to those of blood loss observed in our previous animal studies.ConclusionAn equilibrium-diagram analysis contributes to a quantitative and integrative understanding of function of human sympathetic arterial baroreflex.
Pyrotinib in the Treatment of Women With HER2-Positive Advanced Breast Cancer: A Multicenter, Prospective, Real-World Study
Authors: Zhang Lili , Wu Xiaohong , Zhou Jun , Zhu Mingzhen , Yu Hao , Zhang Yusong , Zhao Yutian , Han Zhengxiang , Guo Yujiang , Guan Xiaoqing , Wang Xufen , Xu Hong , Sun Li , Zhang Jiaxin , Zhuang Min , Xie Li , Yu Shiyou , Chen Ping , Feng Jifeng 
Published: July 2021

BackgroundHER2-positive breast cancer was aggressive, resulting in a poorer prognosis. This multicenter study analyzed the real-world data of women treated with pyrotinib-based therapy, aiming to describe their characteristics, treatment regimens, and to investigate the clinical outcomes.MethodsA total of 141 patients with HER2-positive breast cancer were enrolled from February 2019 to April 2020. Last follow-up time was February 2021. All patients were treated with pyrotinib-based therapy in 21-day cycles. The primary endpoint was progression-free survival (PFS).ResultsThe median PFS (mPFS) for pyrotinib-based therapy was 12.0 months (95%CI 8.1-17.8) in all patients. Among the patients with liver metastases, mPFS was 8.7 months (95%CI, 6.3-15.4) compared to 12.3 months (95%CI, 8.8-23.3) for patients without liver metastases (P=0.172). In addition, patients receiving pyrotinib-based therapy as their &gt;2 lines treatment had a numerically lower mPFS than those receiving pyrotinib-based therapy as their ≤2 lines treatment [8.4 (95%CI, 5.9-15.4) vs. 15.1 (95%CI, 9.3-22.9) months, P=0.107]. The mPFS was 12.2 months (95%CI, 7.9-18.8) in patients with previous exposure to trastuzumab and 11.8 months (95%CI, 6.8-22.9) in patients without previous exposure to trastuzumab (P=0.732). Moreover, mPFS in patients receiving regimens with and without capecitabine were 15.1 months (95%CI, 10.0-18.8) and 8.4 months (95%CI, 6.7-22.9), respectively (P=0.070). Furthermore, in patients with brain metastases, estimated 6-month PFS rate was 70.0%, and rate at 12 months was 60.0%. Seventy patients with measurable lesions were evaluable for response. The objective response rate was 38.6% and disease control rate was 85.7%. The most common adverse event was diarrhea (85.0%).ConclusionPyrotinib-based therapy showed promising efficacy in patients with HER2-positive breast cancer and was well tolerated, especially in patients treated with pyrotinib as ≤2 lines treatment and receiving regimens with capecitabine. The results of this real-world study further confirmed the intriguing efficacy of pyrotinib.
Real-World Analysis of Survival and Clinical Events in a Cohort of Italian Perinatally HIV-1 Infected Children From 2001 to 2018
Authors: Chiappini Elena , Larotonda Francesca , Lisi Catiuscia , Giacomet Vania , Erba Paola , Bernardi Stefania , Zangari Paola , Di Biagio Antonio , Taramasso Lucia , Giaquinto Carlo , Rampon Osvalda , Gabiano Clara , Garazzino Silvia , Tagliabue Claudia , Esposito Susanna , Bruzzese Eugenia , Badolato Raffaele , Zanaboni Domenico , Cellini Monica , Dedoni Maurizio , Mazza Antonio , Pession Andrea , Giannini Anna Maria , Salvini Filippo , Dodi Icilio , Carloni Ines , Cazzato Salvatore , Tovo Pier Angelo , de Martino Maurizio , Galli Luisa 
Published: July 2021

Background:Combined antiretroviral therapy (cART) has been associated with a steep decrease in mortality and morbidity in HIV-1 infected children. New antiretroviral molecules and drug classes have been developed and the management of HIV-infected children has improved, but recent data on survival are limited.Methods:An observational retrospective study investigating changes in mortality and morbidity was conducted on 1,091 perinatally HIV-1 infected children enrolled in the Italian Register for HIV Infection in Children and followed-up from 2001 to 2018.Results:Three hundred and fifty-four (32%) AIDS events and 26 (2%) deaths occurred overtime. Mortality rates decreased from 0.4/100 person-years in 2001–2006 to 0.27/100 person-years in 2007–2012 and 0.07/100 person-years in 2013–2018. Notably, 92% of the dead children were born in Italy, but only 50% were followed-up since birth or within three months of age. Seventy three percent of children had started cART at age ≥6 months; 23% were treated for &lt;30 days before death. B and C clinical events progressively decreased (P&lt; 0.0001). Opportunistic infections significantly decreased over time, but still were the most common events in all the periods (6.76/100 person-years in 2013–2018). In the last period, severe bacterial infections were the most common ones. Cancer rates were 0.07/100; 0.17/100; 0.07/100 person-years in the three periods, respectively.Conclusions:Progressive reductions both in mortality and in rates of class B and C clinical events and OIs have been observed during the cART era. However, deaths were still registered; more than half of dead children were enrolled after birth and had belatedly started cART.
Effectiveness and Acceptance of a Smartphone-Based Virtual Agent Screening for Alcohol and Tobacco Problems and Associated Risk Factors During COVID-19 Pandemic in the General Population
Authors: Auriacombe Marc , Fournet Lucie , Dupuy Lucile , Micoulaud-Franchi Jean-Arthur , de Sevin Etienne , Moriceau Sarah , Baillet Emmanuelle , Alexandre Jean-Marc , Serre Fuschia , Philip Pierre 
Published: July 2021

Background: During the current COVID-19 pandemic, alcohol, and tobacco are the most available substances for managing stress and can induce a risk of addiction. KANOPEE is a smartphone application available to the general population using an embodied conversational agent (ECA) to screen for experiences of problems with alcohol/tobacco use and to provide follow-up tools for brief intervention.Objectives: This study aimed to determine if the smartphone KANOPEE application could identify people at risk for alcohol and/or tobacco use disorders in the context of the current COVID-19 pandemic, to assess adherence to a 7-day follow-up use diary, and to evaluate trust and acceptance of the application.Methods: The conversational agent, named Jeanne, interviewed participants about perceived problems with the use of alcohol and tobacco since the pandemic and explored risk for tobacco and alcohol use disorder with the five-item Cigarette Dependence Scale (CDS-5) and “Cut Down, Annoyed, Guilty, Eye-opener” (CAGE) questionnaire and experience of craving for each substance. Descriptive, univariate, and multivariate analyses were performed to specify personalized associations with reporting a problem with alcohol/tobacco use; descriptive analysis reported the experience with the intervention and acceptance and trust in the application.Results: From April 22 to October 26, 2020, 1,588 French participants completed the KANOPEE interview, and 318 answered the acceptance and trust scales. Forty-two percent of tobacco users and 27% of alcohol users reported problem use since the pandemic. Positive screening with CDS-5 and CAGE and craving were associated with reported problem use (p &lt; 0.0001). Lockdown period influenced alcohol (p &lt; 0.0005) but not tobacco use (p &gt; 0.05). Eighty-eight percent of users reported that KANOPEE was easy to use, and 82% found Jeanne to be trustworthy and credible.Conclusion: KANOPEE was able to screen for risk factors for substance use disorder (SUD) and was acceptable to users. Reporting craving and being at risk for SUD seem to be early markers to be identified. Alcohol problem use seems to be more reliant on contextual conditions such as confinement. This method is able to offer acceptable, brief, and early intervention with minimal delay for vulnerable people.
Prevalence and Incidence of Sexually Transmitted Infection in Injectable Progestin Contraception Users in South Africa
Authors: Noguchi Lisa M. , Marrazzo Jeanne M. , Richardson Barbara , Hillier Sharon L. , Balkus Jennifer E. , Palanee-Phillips Thesla , Nair Gonasagrie , Panchia Ravindre , Piper Jeanna , Gomez Kailazarid , Ramjee Gita , Chirenje Z. Mike 
Published: July 2021

Introduction: Whether intramuscular depot medroxyprogesterone acetate (DMPA-IM) and norethisterone enanthate (NET-EN) have a differential impact on the incidence of sexually transmitted infection (STI) remains unclear. In the Vaginal and Oral Interventions to Control the Epidemic (VOICE) trial, HIV-1 acquisition was higher for DMPA-IM users vs. NET-EN users. We compared DMPA-IM and NET-EN users with regard to chlamydia, gonorrhea, trichomoniasis, syphilis, and herpes simplex virus type 2 (HSV-2) infection.Materials and Methods: Prospective data were analyzed from VOICE, a randomized trial of HIV-1 chemoprophylaxis. Participants were evaluated annually and as indicated for chlamydia, gonorrhea, trichomoniasis, and syphilis. Stored specimens were tested for HSV-2. Proportional hazards models compared the risk of STI between DMPA-IM and NET-EN users.Results: Among 2,911 injectable contraception users in South Africa, 1,800 (61.8%) used DMPA-IM and 1,111 used NET-EN (38.2%). DMPA-IM and NET-EN users did not differ in baseline chlamydia: 15.1 vs. 14.3%, p = 0.54; gonorrhea: 3.4 vs. 3.7%, p = 0.70; trichomoniasis: 5.7 vs.5.0%, p = 0.40; or syphilis: 1.5 vs. 0.7%, p = 0.08; but differed for baseline HSV-2: (51.3 vs. 38.6%, p &lt; 0.001). Four hundred forty-eight incident chlamydia, 103 gonorrhea, 150 trichomonas, 17 syphilis, and 48 HSV-2 infections were detected over 2,742, 2,742, 2,783, 2,945, and 756 person-years (py), respectively (chlamydia 16.3/100 py; gonorrhea 3.8/100 py; trichomoniasis 5.4/100 py; syphilis 0.6/100 py; HSV-2 6.4/100 py). Comparing DMPA-IM with NET-EN users, no difference was noted in the incidence of chlamydia, gonorrhea, trichomoniasis, syphilis, or HSV-2 infections, including when adjusted for confounders [chlamydia (aHR 1.03, 95% CI 0.85–1.25), gonorrhea (aHR 0.88, 95% CI 0.60–1.31), trichomoniasis (aHR 1.07, 95% CI 0.74–1.54), syphilis (aHR 0.41, 95% CI 0.15–1.10), and HSV-2 (aHR 0.83, 95% CI 0.45–1.54, p = 0.56)].Discussion: Among South African participants enrolled in VOICE, DMPA-IM and NET-EN users differed in prevalence of HSV-2 at baseline but did not differ in the incidence of chlamydia, gonorrhea, trichomoniasis, syphilis, or HSV-2 infection. Differential HIV-1 acquisition, previously demonstrated in this cohort, does not appear to be explained by differential STI acquisition. However, the high incidence of multiple STIs reinforces the need to accelerate access to comprehensive sexual and reproductive health services.
Moral e Alienação: uma aproximação entre o jovem Hegel e Nietzsche pela religião
Authors: Zandoná Felipe B. 
Published: July 2021

O presente trabalho pretende apresentar ao leitor uma aproximação entre a moral e a alienação a partir de um diálogo entre o jovem Hegel e Nietzsche. O objetivo geral do artigo é demonstrar - para além das divergências filosóficas - que o Hegel da juventude e Nietzsche possuem um cerne crítico comum no trato da moral. Como objetivo específico, o artigo pretende demonstrar que este cerne crítico da moral passa, primordialmente, pela crítica religiosa e, em especial pelo fenômeno da alienação. Na intenção de atingir os objetivos aqui traçados, tomaremos por base, inicialmente, a alienação como manifestada por Hegel nos seus escritos teológicos de juventude, em especial nas obras O positivismo da religião cristã e O espírito do cristianismo e seu destino. Importante será, na seqüência do trabalho, a crítica religiosa feita por Nietzsche na Genealogia da moral, já que possibilitará uma análise conjunta das duas filosofias e nos levará a um desfecho final do trabalho onde, como conclusão, pretenderá se demonstrar que os efeitos da alienação no jovem Hegel possuem claras semelhanças para com os efeitos da moral em Nietzsche.

Palavras-chave: Hegel. Nietzsche. moral. Alienação