bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonsurgical treatment reduces tendon inflammation and elevates tendon markers in early healing
Authors: Freedman Benjamin R. , Adu‐Berchie Kwasi , Barnum Carrie , Fryhofer George W. , Salka Nabeel S. , Shetye Snehal , Soslowsky Louis J. 
Published: December 2021

AbstractOperative treatment is assumed to provide superior outcomes to nonoperative (conservative) treatment following Achilles tendon rupture, however, this remains controversial. This study explores the effect of surgical repair on Achilles tendon healing. Rat Achilles tendons (n = 101) were bluntly transected and were randomized into groups receiving repair or non‐repair treatments. By 1 week after injury, repaired tendons had inferior mechanical properties, which continued to 3‐ and 6‐week post‐injury, evidenced by decreased dynamic modulus and failure stress. Transcriptomics analysis revealed >7000 differentially expressed genes between repaired and non‐repaired tendons after 1‐week post‐injury. While repaired tendons showed enriched inflammatory gene signatures, non‐repaired tendons showed increased tenogenic, myogenic, and mechanosensitive gene signatures, with >200‐fold enrichment in Tnmd expression. Analysis of gastrocnemius muscle revealed elevated MMP activity in tendons receiving repair treatment, despite no differences in muscle fiber morphology. Transcriptional regulation analysis highlighted that the highest expressed transcription factors in repaired tendons were associated with inflammation (Nfκb, SpI1, RelA, and Stat1), whereas non‐repaired tendons expressed markers associated with tissue development and mechano‐activation (Smarca1, Bnc2, Znf521, Fbn1, and Gli3). Taken together, these data highlight distinct differences in healing mechanism occurring immediately following injury and provide insights for new therapies to further augment tendons receiving repaired and non‐repaired treatments.
Anterior Palatoplasty With Expansion Sphincter Pharyngoplasty for All Type of Pharyngeal Collapse
Authors: Ciğer Ejder , İşlek Akif 
Published: December 2021

Objectives/HypothesisThis study was aimed to compare the efficiency of the anterior palatoplasty and expansion sphincter pharyngoplasty (APwESP) technique for all patterns of velopharyngeal obstruction (anterior–posterior [APPC], lateral [LPC], or combined circular pharyngeal collapse [CPC]).Study DesignThe study was designed as a randomized prospective trial at Kâtip Çelebi University, Atatürk Training, and Research Hospital.MethodsPatients only with velopharyngeal obstruction were included. Three groups were created according to the obstruction pattern (APPC, LPC, and CPC) for the study. Outcome parameters included patient's demographics, apnea‐hypopnea index (AHI), lowest oxygen saturation (LOS), Stanford subjective scale of snoring (SSSS), and Epworth sleepiness scale (ESS).ResultsThirty‐one (34.1%) patients were in APPC group, while 30 (33.0%) patients were in LPC, and 30 (33.0%) were in CPC group. Preoperatively for all patients, on average, AHI was 33.4 ± 13.6, SSSS was 8.3 ± 1.0, ESS was 16.5 ± 2.6, and LOS was determined as 85.5 ± 3.6. There was a significant postoperative improvement in all parameters for all patients. There was no significant difference in outcome parameters between the groups according to obstruction pattern postoperatively. After APwESP surgery, obstruction pattern was not a significant factor for AHI (P = .234), SSSS (P = .180), and LOS (P = .280) (repeated measure analysis of variance test). The rate of surgical success was detected similarly for both of the study groups (P = .435). The rate of successful surgery for severe obstructive sleep apnea in the APPC group was 72.2%, 88.2% in the LPC group, and 75.0% in the CPC group (P = .472).ConclusionA combination of APwESP surgery can manage all types of pharyngeal obstruction confidently.Level of Evidence3 Laryngoscope, 132:1313–1319, 2022
The composition of singular integral operators with nonsmooth kernels
Authors: Hu Guoen , Zhang Yandan 
Published: December 2021

AbstractLet T1, T2 be two singular integral operators with nonsmooth kernels introduced by Duong and McIntosh. In this paper, by establishing certain bi‐sublinear sparse dominations, the authors obtain some quantitative bounds on with and for the composite operator . Some weighted weak type endpoint estimates are also given.
Rational Process Design for Facile Fabrication of Dual Functional Hybrid Membrane of MOF and Electrospun Nanofiber towards High Removal Efficiency of PM2.5 and Toxic Gases
Authors: Kim Donghun , Kim Yoonjin , Kim Dokun , Son Dongwan , Doh Song Jun , Kim Myungwoong , Lee Hoik , Yoon Ki Ro 
Published: December 2021

AbstractThe application of nanofiber (NF) and porous metal‐organic framework (MOF) has increasingly attracted attention for the protection of public health. This composite platform provides the physical sieving of particulate matters (PMs) and capturing gases, serving as an outstanding filtering medium with lightweight and multifunctionality. Herein, process design and optimization are performed to produce a multifunctional membrane comprised NFs and MOF particles. Electrospinning/electrospray techniques are used to fabricate a hybrid membrane of poly(vinyl alcohol) NF and Fe‐BTC as an adsorptive MOF on a macroporous nonwoven (NW). Three types of filters are prepared by varying the order of processing steps, that is, MOF/NF/NW, MOF+NF/NW, and NF/MOF/NW, to elucidate the effect of the fabrication process in the filtration of air pollutant. The optimal filtration performance is achieved in MOF+NF/NW system: the highest filtration efficiency (97%) and outstanding gas capturing efficiencies (≈60% and ≈35% decreases from initial NH3 and H2S concentrations, respectively). However, when air permeability and filtration efficiency are considered, the most desirable configuration for personal protection equipment (PPE) is NF/MOF/NW system, which effectively enabled comfortable breathing without compromising the lightweight and multifunctional performance.
Second‐order efficient nonlinear filter stabilization for high Reynolds number flows
Authors: Takhirov Aziz , Trenchea Catalin , Waters Jiajia 
Published: December 2021

AbstractIn this article, we develop a second‐order nonlinear filter based stabilization scheme for high Reynolds number flows. We prove the unconditional stability of the method, establish the second order consistency and discuss the dynamical tuning of the relaxation parameter. The scheme is then validated against experimental data for an isothermal turbulent flow in a Staggered Tube Bundle at Reynolds number of 18,000. Numerical results are found to be in an overall good qualitative and quantitative agreement with the benchmark results.
Recontextualizing street‐level bureaucracy in the developing world
Authors: Lotta Gabriela , Pires Roberto , Hill Michael , Møller Marie Ostergaard 
Published: December 2021

AbstractThis Special Issue was driven by the need to better understand the theoretical, methodological, and practical implications of the growing mobilization of the street‐level bureaucracy (SLB) analytical framework in the study of state action and policy implementation in the developing world. Our curiosity rested on what has been happening to the framework in terms of empirical applications as well as the consequent challenges to the theory when it travels from the Global North to the Global South. We wanted to learn more about the evolution of ideas and theoretical propositions developed on the basis of some important assumptions—such as consolidated liberal states and advanced democracies—when they reach the specific conditions and varying contexts of states and societies in the developing world.
Optimization on diffeological spaces
Authors: Goldammer Nico , Welker Kathrin 
Published: December 2021

AbstractOn this poster, we present optimization techniques on diffeological spaces. Diffeological spaces firstly introduced by J.M. Souriau in the 1980s are a natural generalization of smooth manifolds. In order to generalize optimization methods known on manifolds to diffeological spaces, we define various objects like a diffeological tangent space, a diffeological Riemannian space as well as a diffeological gradient. In addition we give the definition of a diffeological retraction. These objects are necessary for formulating the steepest descent method on diffeological spaces. We present this method and apply it on an example.
Viscous energy dissipation reduction by optimization of multiple shapes
Authors: Suchan Tim , Welker Kathrin 
Published: December 2021

AbstractShape optimization has been an active field of research for the past decades and is used especially in engineering. On this poster, we consider a shape optimization model with multiple shapes, i.e., we consider more than one shape to be optimized. We assume that the optimization variable is a set Γ = (Γ1,…, ΓN) of non‐intersecting shapes contained in a bounded domain D ⊂ ℝd. We note that D depends on Γ, i.e., D = D(Γ). On this poster, a shape optimization of a two‐dimensional fluid‐mechanical problem is considered. We minimize the viscous energy dissipation in the fluid domain D, more precisely

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subject to the equations describing Stokes flow

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with appropriate boundary conditions, where y ∈ ℝ2 describes the fluid velocity, p ∈ ℝ the pressure, and f ∈ ℝ2 a given source term. In order to solve the minimization problem, we use an optimization approach based on the Steklov‐Poincaré metric, where the so‐called weak form of the shape derivative can be used. The algorithm and implementation details are presented, and numerical results are discussed for the optimization of multiple shapes in the fluid domain.
In‐silico selection of cancer blood plasma proteins by integrating genomic and proteomic databases
Authors: Chatterjee Gaurab , Ferris Bryn , Momenbeitollahi Nikan , Li Huiyan 
Published: December 2021

AbstractBlood protein markers have been studied for the clinical management of cancer. Due to the large number of the proteins existing in blood, it is often necessary to pre‐select potential protein markers before experimental studies. However, to date there is a lack of automated method for in‐silico selection of cancer blood proteins that integrates the information from both genetic and proteomic studies in a cancer‐specific manner. In this work, we synthesized both genomic and proteomic information from several open access databases and established a bioinformatic pipeline for in‐silico selection of blood plasma proteins overexpressed in specific type of cancer. We demonstrated the workflow of this pipeline with an example of breast cancer, while the methodology was applicable for other cancer types. With this pipeline we obtained 10 candidate biomarkers for breast cancer. The proposed pipeline provides a useful and convenient tool for in‐silico selection of candidate blood protein biomarkers for a variety of cancer research.
Achieving flame retardancy and mechanical integrity via phosphites in bio‐based resins
Authors: Custodio Kenee Kaiser S. , Walsh Tiffany R. 
Published: December 2021

AbstractBio‐based flame retardant (FR) resins typically exhibit diminished mechanical properties compared with their petroleum‐based counterparts. Recent experiments identified a promising FR phosphorus‐bearing vanillin‐based epoxy resin, EP2, that exhibited superior thermomechanical properties compared to that of petroleum‐based diglycidyl ether of bisphenol A. However, the structure/property relationships of such phosphorus‐containing bio‐based resins are relatively under‐explored and cannot be resolved via experiments alone. Here, molecular simulations are used to explore these relationships for a resin comprising EP2 cured with 4,4‐diaminodiphenylmethane. The predicted thermomechanical properties are consistent with experimental observations, and critically, the structural analysis reveals the importance of the pendant phosphite group in the monomer as central to maintaining extensive hydrogen‐bonding networks, giving rise to the excellent Young's modulus. This work provides the foundation for knowledge‐based strategies to systematically improve the structure/property relationships in FR bio‐based epoxy resins.
Laminaria japonica cyclic peptides exert anti‐colorectal carcinoma effects through apoptosis induction in vitro and in vivo
Authors: Du Xueting , Xiao Shengwei , Luo Qiang , Liu Xiaolei , Liu Jie 
Published: December 2021

Laminaria japonica is consumed as a health food and used as a traditional medicine because of its biochemical and pharmacological abilities. However, the anti‐tumor effect of L. japonica peptides has not been well explored. In the current study, three novel L. japonica cyclic peptides (LCPs) were isolated using an anti‐cancer activity tracking method. LCP‐3 [cyclo‐(Trp‐Leu‐His‐Val)] significantly induced apoptosis in Caco‐2 cells in vitro. LCP‐3 increased the Bax/Bcl‐2 ratio, activated caspases, and regulated the p53/murine double minute 2 network. LCP‐3 blocked Caco‐2 cells in G0/G1 phase, which was accompanied by the inhibition of cyclin expression. Furthermore, LCP‐3 inhibited colon cancer growth and induced cancer cell apoptosis in tumor‐bearing mice. Notably, LCP‐3 might be a potential agent for the prevention of colon cancer.
K‐filter‐based adaptive output feedback control for high‐order nonlinear systems subject to actuator and sensor attacks
Authors: Gao Rui , Huang Jiangshuai , Su Xiaojie , Zhao Ling 
Published: December 2021

AbstractIn this article, the security control problem of a class of high‐order nonlinear cyber‐physical systems is investigated where the actuator and sensor are suffered from deceptive cyber‐attacks. By assuming that only the contaminated system output is available for feedback control, a set of K‐filters are applied to develop a novel observer to reveal the state information, and based on which an adaptive control law is designed. It is shown that asymptotic stability of nonlinear systems and boundedness of all the closed‐loop signals can be guaranteed using backstepping method even in presence of adversarial attacks. Simulations results illustrate the effectiveness of the proposed algorithms.
Recalcitrant Erythrodermic Ichthyosis with Atopic Dermatitis Successfully Treated with Dupilumab in Combination with Guselkumab
Authors: Steinhoff M. , Al-Marri F. , Al Chalabi R. , Gieler U. , Buddenkotte J. 
Published: December 2021

Abstract

Background
Autosomal recessive congenital ichthyosis refers to a group of rare inherited disorders of keratinization and defective epidermal barrier resulting in varying clinical presentations and severities ranging from harlequin ichthyosis to congenital ichthyosiform erythroderma (CIE). Secondary atopic dermatitis (AD) can aggravate the disease state for CIE patients leading to recalcitrant CIE/AD with potentially unfavourable side effects and low tolerability.

Aims
Here, we report about a 38-year-old male patient with severe CIE as well as AD over the last 30 years.

Materials and Methods
The patients suffered from severe inflammation, pruritus and recurrent infections for decades without disease control and intolerable adverse events of previous therapies.

Results
Dupilumab (targeting IL-4Ra, 300 mg q2w) partially controlled pruritus, but only the combination of Dupilumab with Guselkumab (anti-IL23p19) controlled both CIE and AD with markedly reduced inflammation, itch and recurrent infections. Guselkumab alone was not sufficient to treat the severe CIE/AD.

Discussion
Further studies are required to assess the efficacy and safety of targeted therapies like Dupilumab/Guselkumab combination therapy in severe CIE/AD.
Dry Reforming of Methane over Ni/MgO@Al Catalysts with Unique Features of Sandwich Structure
Authors: Dai Hui , Zhu Yongqing , Xiong Siqi , Xiao Xin , Huang Lihong , Deng Jie , Zhou Changjian 
Published: December 2021

AbstractDry reforming of methane (DRM) reaction can eliminate CH4 and CO2, the two main greenhouse gases. However, the industrialization of Ni‐based catalysts has been restricted by the problems of sintering and carbon deposition in common use. In this work, a series of sandwich structure catalyst Ni/MgO@Alx with traditional Ni/MgO and core‐shell Ni@Al2O3 were characterized and analyzed. Extensive catalyst characterization using N2 adsoptron‐desorption isotherms, X‐ray diffraction (XRD), transmission electron microscope (TEM), temperature‐programmed reduction/ desorption (TPR/D), Raman and thermogravimetric analysis (TGA) indicates that the sandwich structure catalyst has high activity, and the suitable shell thickness directly determines the mass transfer and surface acidity and basicity of the catalyst. However, in the process of reaction, the carbon tube grows on the top of the active component, resulting in its stability is not as good as Ni@Al2O3. Under the conditions of high gas velocity of 18000 mL gcat−1 h−1 with a reaction gas ratio of CO2 : CH4=1 : 1, after 30 hours of reaction with Ni/MgO@Al0.6 catalyst at 750 °C, the conversion of CH4 and CO2 remained at 79 % and 83 %, respectively.
A Facile Approach to Access Multi‐Substituted Indenes via Nazarov Cyclisation of Aryl, Vinyl, and Alkyl/Aryl Carbinols
Authors: Chakraborty Mithun , Mahesh Gaddam , Nakel Omkar R. , Chavda Gautamee , Anusha Susarla , Sudhakar Gangarajula 
Published: December 2021

AbstractA divergent approach to highly substituted functionalized indenes has been developed. The two‐step reaction involving nucleophilic addition reaction of aryl vinyl ketone, an ideal intermediate with aryl or alkyl nucleophilic reagent, followed by electrocyclic reaction (Nazarov cyclization) in the presence of Lewis acid catalyst afforded indene derivatives in good to excellent yield.
Novel Carboxylic Acid Functionalized Dendronized Polymer: A Homogeneous, Reusable Metal Free Acid Catalyst for the Synthesis of Symmetric and Unsymmetric Xanthene Derivatives
Authors: Hiba Kottayil , Shaibuna Machingal , Prathapan Sreedharan , Sreekumar Krishnapillai 
Published: December 2021

AbstractIn the present study, carboxylic acid‐functionalized tris(hydroxymethyl)propane initiated polyepichlorohydrin cored dendronized polymer (TMP‐PECH‐COOH) was successfully synthesized. Successful incorporation of carboxylic acid functionality was evidenced by Fourier transform infrared spectroscopy (FT‐IR), thermogravimetric analysis (TG/DTG), and NMR spectroscopy (1H NMR). Thermodynamic properties such as thermal energy, enthalpy, and Gibb's free energy as well as global reactivity descriptors such as chemical potential, chemical hardness, and electrophilicity index of the TMP‐PECH‐COOH dendronized polymer were investigated using Gaussian 09 program employing the hybrid density functional B3LYP method and 6‐31G basis set. The synthesized dendronized polymer (TMP‐PECH‐COOH) could act as a metal‐free acid catalyst for catalyzing the reactions for the synthesis of 1,8‐dioxooctahydroxanthenes and tetrahydrobenzoxanthene‐11‐ones under mild reaction conditions in an aqueous medium. The catalyst could be reused at least six times making the present procedure facile, practical, and sustainable. In addition, the efficiency of the present catalyst was compared with some previous reports.
Study of the Synthesis and Application of a Fluorescence‐Enhanced Mg2+ Probe
Authors: Wang Huizhen , Xue Songsong , Xiao Guilong , Du Cheng , Liu Jiaqin , Xie Zhengfeng 
Published: December 2021

AbstractA Schiff base fluorescent probe compound H2L (N′‐(4‐bromo‐2‐hydroxy‐benzylidene)‐3‐hydroxy‐2naphthohydrazide) was synthesized using 3‐hydroxy‐2‐naphthoic acid hydrazide as raw material. The structure of H2L was characterized by NMR, IR, MS, and XRD methods. The fluorescence performance of H2L was studied by UV and FS. The results show that in 1 : 4 water system /DMSO solution (water system: 20 % triethanolamine:0.1 mol/L L‐cysteamine acid=1 : 1), H2L can be used to quickly identify Mg2+ with an obvious fluorescence enhancement and redshift. A color change “light green→bright yellow” can be clearly observed with the naked eye. The Mg2+ concentration shows a good linear relationship in the range of 0–1.0×10−5 mol/L, with a detection limit of 1.77×10−7 mol/L with good stability and reversibility. The response mechanism was explored through Job's curve, NMR titration and MS, which showed that Mg2+ can form a 1 : 1 complex with H2L. A gel (SAL) was prepared by doping H2L into sodium alginate (SA). SAL was found to show good adsorption properties for Mg2+ and can be easily distinguished by the naked eye under ultraviolet light. The microscopic morphology and composition of SAL before and after Mg2+ adsorption were analyzed by SEM‐EDS. H2L can be used for the qualitative detection of Mg2+ in actual water samples without being affected by other common metal ions, and has potential application value in the field of environmental detection.
Synthesis of Catechol Thioethers through Gallic Acid/Fe2(SO4)3 Catalyzed Aerobic Oxidative Coupling of Thiols and Catechol Derivatives
Authors: Si Mengyuan , Liu Zhongyuan , Dou Yingchao , Yang Guanyu 
Published: December 2021

AbstractA newly developed cooperative catalytic system Galic acid/Fe2(SO4)3 was employed in the syntheses of catechol thioethers through the direct aerobic oxidative coupling of various thiols with catechol derivatives. As the first organocatalytic oxidative method to prepare catechol thioethers except the enzymatical cases, it exhibits good tolerance and selectivity, leading to the good products in up to 95 % yields. It was postulated to undergo the divergent Michael‐type nucleophilic conjugate addition (1,4‐type or 1,6‐type) of the thiols onto the in‐situ generated ortho‐benzoquinones.
Autonomic behavioral impairment induced by simazine exposure during early life of male mouse is mediated by Lmx1a/Wnt1 pathway
Authors: Li Xueting , Hu Xiaomeng , Jiang Yujia , Wang Dandan , Wang Ting , Li Baixiang 
Published: December 2021

AbstractSimazine is a widely used herbicide and known as an environmental estrogen. Multiple studies have proved simazine can induced the degeneration of dopaminergic neuron resulting in a degenerative disease‐like syndrome. Herein, we explored the neurotoxicity of simazine on the dopaminergic nervous system of embryos and weaned offspring during the maternal gestation period or the maternal gestation and lactation periods. We found that simazine disturbed the crucial components expression involved in Lmx1a/Wnt1 pathway of dopaminergic neuron in embryonic and weaned offspring. Furthermore, morphological and behavioral tests performed on weaned male offspring treated by simazine suggested that the grip strength, autonomic exploring, and the space sense ability were weakened, as well as the pathological damage of dopaminergic neuron was clearly observed. But, the same neurotoxicity of simazine is less significantly observed in female offspring. Our findings will provide reliable reference for the determination of environmental limits and new insight into the pathogenesis of nonfamilial neurodegenerative diseases related to environmental risk factors.