bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life satisfaction after stroke and the association with upper extremity disability, sociodemographics, and participation
Authors: Ekstrand Elisabeth , Brogårdh Christina 
Published: September 2021

AbstractIntroductionRemaining disability after stroke can reduce a person's life satisfaction. Because previous studies of life satisfaction show inconsistent results, there is a need for more knowledge regarding perceived life satisfaction after stroke and associated factors.ObjectiveTo assess perceived life satisfaction after stroke in relation to Swedish reference values; and the association with upper extremity disability, sociodemographics, and participation.DesignCross‐sectional study.SettingUniversity hospital.ParticipantsSeventy‐five persons (72% male) with mild to moderate disability in a stable phase after stroke.InterventionsNot applicable.Main Outcome MeasureLife satisfaction was assessed with the Life Satisfaction Questionnaire (LiSat‐11), which includes one global item Life as a whole and 10 domain‐specific items. Global life satisfaction and explanatory factors were evaluated in two multivariate logistic regression models.ResultsFifty‐three percent of the participants were satisfied with Life as a whole. Highest satisfaction was found for Family life (78%) and Partner relationship (77%) and lowest satisfaction for Vocational situation (32%), Sexual life (25%), and Physical health (23%). Life as a whole and most domain‐specific items showed a significantly lower proportion of satisfied persons compared to Swedish reference values. In the first regression model with factors of upper extremity disability, manual ability was the strongest explanatory variable for Life as a whole (p value = .032, Nagelkerke R Square 0.117). In the second regression model, participation, social, and working status were the final explanatory variables (p value = .006, Nagelkerke R Square = 0.207).ConclusionOur findings indicate that persons with mild to moderate disability after stroke perceive overall less satisfaction with Life as a whole and domain‐specific items than the general Swedish population. To increase a person's life satisfaction after stroke, rehabilitation interventions should target a variety of aspects including enhancing functioning of upper extremity, reducing participation restrictions, and providing support regarding social and vocational situation.
Predictors of cancer screening among Black and White Maryland Medicaid enrollees with serious mental illness
Authors: Murphy Karly A. , Daumit Gail L. , McGinty Emma E. , Stone Elizabeth M. , Kennedy‐Hendricks Alene 
Published: September 2021

AbstractBackgroundCancer is the second leading cause of death for people with serious mental illness (SMI), such as schizophrenia and bipolar disorder. People with SMI receive cancer screenings at lower rates than the general population.AimsWe sought to identify factors associated with cancer screening in a publicly insured population with SMI and stratified by race, a factor itself linked with differential rates of cancer screening.Materials and MethodsWe used Maryland Medicaid administrative claims data (2010–2018) to examine screening rates for cervical cancer (N = 40,622), breast cancer (N = 9818), colorectal cancer (N = 19,306), and prostate cancer (N = 4887) among eligible Black and white enrollees with SMI. We examined individual‐level socio‐demographic and clinical factors, including co‐occurring substance use disorder, medical comorbidities, psychiatric diagnosis, obstetric‐gynecologic and primary care utilization, as well as county‐level characteristics, including metropolitan status, mean household income, and primary care workforce capacity. Generalized estimating equations with a logit link were used to examine the characteristics associated with cancer screening.ResultsCompared with white enrollees, Black enrollees were more likely to receive screening for cervical cancer (AOR: 1.18; 95% CI: 1.15‐1.22), breast cancer (AOR: 1.27; 95% CI: 1.19‐1.36), and colorectal cancer (AOR: 1.07; 95% CI: 1.02‐1.13), while similar rates were observed for prostate cancer screening (AOR: 1.06; 95% CI: 0.96‐1.18). Primary care utilization and longer Medicaid enrollment were positively associated with cancer screening while co‐occurring substance use disorder was negatively associated with cancer screening.ConclusionImproving cancer screening rates among populations with SMI should focus on facilitating continuous insurance coverage and access to primary care.
Label‐free quantitative proteomic and phosphoproteomic analyses of renal biopsy tissues in membranous nephropathy
Authors: Li Shanshan , Luo Zhifeng , Meng Shuhui , Qiu Xiaofen , Zheng Fengping , Dai Weier , Zhang Xinzhou , Sui Weiguo , Yan Qiang , Tang Donge , Dai Yong 
Published: September 2021

AbstractPurposeMembranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. However, the underlying mechanisms of its occurrence and development are not completely clear. Thus, it is essential to explore the mechanisms.Experimental designHere, we employed label‐free quantification and liquid chromatography‐tandem mass spectrometry analysis techniques to investigate the proteomic and phosphoproteomic alterations in renal biopsy tissues of MN patients. Samples were collected from 16 MN patients and 10 controls. Immunohistochemistry (IHC) was performed to validate the hub phosphoprotein.ResultsWe focused on the changes in the phosphoproteome in MN group versus control group (CG). Totally, 1704 phosphoproteins containing 3241 phosphosites were identified and quantified. The phosphorylation levels of 216 phosphoproteins containing 297 phosphosites were differentially regulated in stage II MN group versus CG, and 333 phosphoproteins containing 461 phosphosites were differentially phosphorylated in stage III MN group versus CG. In each comparison, several differential phosphoproteins were factors, kinases and receptors involved in cellular processes, biological regulation and other biological processes. The subcellular location of most of the differential phosphoproteins was the nucleus. Protein–protein interaction analysis showed that the connections among the differential phosphoproteins were extremely complex, and several signalling pathways probably associated with MN were identified. The hub phosphoprotein was validated by IHC.Conclusions and clinical relevanceThis investigation can provide direct insight into the global phosphorylation events in MN group versus CG and may help to shed light on the potential pathogenic mechanisms of MN.
Parametric inference of the loss based index Cpm for normal distribution
Authors: Saha Mahendra , Dey Sanku , Wang Liang 
Published: September 2021

AbstractThe process capability index (PCI) has been introduced as a tool to aid in the assessment of process performance and most of the traditional PCIs performed well when process follows the normal behavior. In this article, we consider a PCI, for normal random variables. The objective of this article is five fold: First, six different methods of estimation of the PCI are addressed from frequentist approaches and compare them in terms of their mean squared errors using extensive numerical simulations. Second, we compare three bootstrap confidence intervals (BCIs) of the PCI including standard bootstrap, percentile bootstrap, and bias‐corrected percentile bootstrap. Third, Bayesian estimation is considered under four loss functions (symmetric as well as asymmetric) using normal prior for location parameter and inverse gamma prior for the scale parameter for the considered model. Also, we obtain highest posterior density (HPD) credible intervals of the PCI . Fourth, a new cost effective PCI, namely, is introduced by incorporating tolerance cost function in the index . Fifth, the power of the test is obtained, and Monte Carlo simulation study has been carried out to compare the performances of the classical BCIs and HPD credible intervals of PCIs and in terms of average widths and coverage probabilities. Finally, two real data sets have been analyzed for illustrative purposes.
Critical Evaluation of the Undergraduate Curriculum—Are We Asking the Right Questions?
Authors: Salava A. 
Published: September 2021

Abstract
The curricular content in medical education needs continuous development and therefore must regularly undergo a critical evaluation. Here, the author describes an implemented shift in the teaching substance of an undergraduate dermatology course aimed to focus on relevance and practicability for general practitioners. The changes were based on a comprehensive nationwide database analysis of the spectrum of skin-related conditions seen in primary care.
Associations between mental health and job loss among middle‐ and low‐income veterans and civilians during the COVID‐19 pandemic: An exploratory study
Authors: Umucu Emre , Reyes Antonio , Nay Andrew , Elbogen Eric , Tsai Jack 
Published: September 2021

AbstractThis study examined the relationship between job loss and mental health during the pandemic among a nationally representative sample of middle‐ and low‐income military veterans and civilians. Participants were recruited from Amazon Mechanical Turk in May–June 2020. Our sample was comparable to the U.S. population with respect to key demographics (i.e., sex, race, ethnicity, and geographic region). More veterans were male (36.9% civilians vs. 74.1% veterans), and on average they were older than civilians (Mcivilians = 47.86 vs. Mveterans = 52.64). After controlling for sociodemographic factors, probable anxiety (adjusted odds ratio for veterans = 1.96, 95% [1.22–3.15]) was significantly associated with job loss among veterans, whereas among civilians, probable anxiety (adjusted odds ratio for civilians [AORc] = 1.48, 95% [1.21–1.81]), probable COVID‐19 era‐related stress (AORc = 1.73, 95% [1.45–2.07]), and loneliness (AORc = 1.09, 95% [1.04–1.13]) were associated with job loss. Results demonstrated that veteran sample's effect sizes were larger than civilian sample's effect sizes; however, our moderation analyses results revealed that veteran status did not moderate the relationships between mental health and job loss. The findings in this study support a relationship between job loss and poorer mental health, suggesting that increased mental health services may be important to address ongoing effects of the COVID‐19 pandemic.
Fermions on wobbling kinks: normal versus quasinormal modes
Authors: Campos João G. F. , Mohammadi Azadeh 
Published: September 2021

Abstract
The system consisting of a fermion in the background of a wobbling kink is studied in this paper. To investigate the impact of the wobbling on the fermion-kink interaction, we employ the time-dependent perturbation theory formalism in quantum mechanics. To do so, we compute the transition probabilities between states given in terms of the Bogoliubov coefficients. We derive Fermi’s golden rule for the model, which allows the transition to the continuum at a constant rate if the fermion-kink coupling constant is smaller than the wobbling frequency. Moreover, we study the system replacing the shape mode with a quasinormal mode. In this case, the transition rate to continuum decays in time due to the leakage of the mode, and the final transition probability decreases sharply for large coupling constants in a way that is analogous to Fermi’s golden rule. Throughout the paper, we compare the perturbative results with numerical simulations and show that they are in good agreement.
Flavor symmetries in the Yukawa sector of non-supersymmetric SO(10): numerical fits using renormalization group running
Authors: Ohlsson Tommy , Pernow Marcus 
Published: September 2021

Abstract
We consider a class of SO(10) models with flavor symmetries in the Yukawa sector and investigate their viability by performing numerical fits to the fermion masses and mixing parameters. The fitting procedure involves a top-down approach in which we solve the renormalization group equations from the scale of grand unification down to the electroweak scale. This allows the intermediate scale right-handed neutrinos and scalar triplet, involved in the type I and II seesaw mechanisms, to be integrated out at their corresponding mass scales, leading to a correct renormalization group running. The result is that, of the 14 models considered, only two are able to fit the known data well. Both these two models correspond to ℤ2 symmetries. In addition to being able to fit the fermion masses and mixing parameters, they provide predictions for the sum of light neutrino masses and the effective neutrinoless double beta decay mass parameter, which are both within current observational bounds.
Mixed QCD-EW corrections for Higgs leptonic decay via HW+W− vertex
Authors: Ma Chichuan , Wang Yuxuan , Xu Xiaofeng , Yang Li Lin , Zhou Bin 
Published: September 2021

AbstractWe consider the two-loop corrections to theHW+W−vertex at orderααs. We construct a canonical basis for the two-loop integrals using the Baikov representation and the intersection theory. By solving theϵ-form differential equations, we obtain fully analytic expressions for the master integrals in terms of multiple polylogarithms, which allow fast and accurate numeric evaluation for arbitrary configurations of external momenta. We apply our analytic results to the decay processH→νeeW, and study both the integrated and differential decay rates. Our results can also be applied to the Higgs production process viaWboson fusion.
Comparison of different treatments for children with radial neck fracture and analysis of prognostic factors
Authors: Xia Anning , You Chao , Han Jingming , Wu Dechao , Xia Yongjie , Wang Jiangsheng 
Published: September 2021

Abstract
Introduction
The aim of this was to analyze the effect of different treatment options on radial neck fractures in children and to explore the factors affecting the prognosis of fractures.

Methods
The clinical data of 131 children with radial neck fractures admitted to our hospital from 2010 to 2018 were retrospectively analyzed, and the patients were divided into 6 groups according to treatment methods [manual reduction with Kirschner wires (K-wires) for internal fixation (group A); manual reduction with elastic stable intramedullary nails (ESINs) for internal fixation (group B); leverage reduction with K-wires for internal fixation (group C); leverage reduction with ESINs for internal fixation (group D); manual and leverage reduction with K-wires/ESINs for internal fixation (group E); and open reduction with K-wires/ESINs for internal fixation (group F)]. Postoperative elbow function and complications were analyzed.

Results
Among the 131 patients with fractures, the median age was 8 years, the median preoperative angulation was 52°, the follow-up rate was 86.3% (113/131), the average follow-up time was 58.3 months, and the postoperative complication rate was 17.7% (20/113). The comparison among the different treatment groups showed that group B had the best recovery of elbow function, postoperatively, and the lowest postoperative complication rate. Age, duration of hospitalization, and preoperative angulation were independent factors affecting postoperative complications. Older age, longer duration of hospitalization, and higher angulation increase the postoperative complications.

Conclusion
Different treatment options have different efficacies for radial neck fractures in children, of which manipulative reduction with internal fixation using ESINs can achieve good efficacy and a low postoperative complication rate. Age, duration of hospitalization, and preoperative angulation are independent factors for postoperative complications.
Österreichisches Neugeborenen-Screening – Früherkennung von Vitamin-B12-Mangel im Fokus
Authors: Konstantopoulou Vassiliki , Greber-Platzer Susanne , Zeyda Maximilian 
Published: September 2021

ZusammenfassungDas österreichische Neugeborenen-Screening ist seit mehr als 50 Jahren eine sehr erfolgreiche Errungenschaft der Präventivmedizin und wird kontinuierlich an die Entwicklungen von Diagnostika, Therapien und Kenntnissen über Zielkrankheiten angepasst. Obwohl seit Langem bekannt, aber als Nebenbefund angesehen, wurde der Vitamin-B12-Mangel bei Neugeborenen kürzlich in den Fokus des österreichischen Neugeborenen-Screenings gerückt. Diese Entwicklung ist auf technische Innovationen zurückzuführen, die den Nachweis eines Verdachts (Messung von Homozystein in aufgrund eines angepassten Screening-Algorithmus identifizierten Proben) verbessern, sowie auf aktuelle Ernährungstrends wie Vegetarismus und Veganismus, die – zumindest teilweise – für die hohe Prävalenz des Vitamin-B12-Mangels insbesondere bei gestillten Kindern verantwortlich sind. Obwohl zu diesem Thema noch Forschungsbedarf besteht, ist es schlüssig, dass durch frühzeitige, präsymptomatische Erkennung eines Vitamin-B12-Mangels im Neugeborenenalter und anschließende Behandlung Entwicklungsstörungen und andere neurologische Störungen vermieden werden können.
Sub-millisecond 2D MRI of the vocal fold oscillation using single-point imaging with rapid encoding
Authors: Fischer Johannes , Özen Ali Caglar , Ilbey Serhat , Traser Louisa , Echternach Matthias , Richter Bernhard , Bock Michael 
Published: September 2021

Abstract
Objective
The slow spatial encoding of MRI has precluded its application to rapid physiologic motion in the past. The purpose of this study is to introduce a new fast acquisition method and to demonstrate feasibility of encoding rapid two-dimensional motion of human vocal folds with sub-millisecond resolution.

Method
In our previous work, we achieved high temporal resolution by applying a rapidly switched phase encoding gradient along the direction of motion. In this work, we extend phase encoding to the second image direction by using single-point imaging with rapid encoding (SPIRE) to image the two-dimensional vocal fold oscillation in the coronal view. Image data were gated using electroglottography (EGG) and motion corrected. An iterative reconstruction with a total variation (TV) constraint was used and the sequence was also simulated using a motion phantom.

Results
Dynamic images of the vocal folds during phonation at pitches of 150 and 165 Hz were acquired in two volunteers and the periodic motion of the vocal folds at a temporal resolution of about 600 µs was shown. The simulations emphasize the necessity of SPIRE for two-dimensional motion encoding.

Discussion
SPIRE is a new MRI method to image rapidly oscillating structures and for the first time provides dynamic images of the vocal folds oscillations in the coronal plane.
‘Pollen potency’: the relationship between atmospheric pollen counts and allergen exposure
Authors: Tegart Lachlan J. , Johnston Fay H. , Borchers Arriagada Nicolas , Workman Annabelle , Dickinson Joanne L. , Green Brett J. , Jones Penelope J. 
Published: September 2021

AbstractPollen allergies are responsible for a considerable global public health burden, and understanding exposure is critical to addressing the health impacts. Atmospheric pollen counts are routinely used as a predictor of risk; however, immune responses are triggered by specific proteins known as allergens, which occur both within and on the surface of the pollen grain. The ratio between atmospheric pollen counts and allergen concentrations (‘pollen potency’) has been shown to be inconsistent, with potentially important implications for pollen monitoring practice. Despite this, there has been no previous synthesis of the literature and our understanding of the factors that influence pollen potency remains poor. We conducted a scoping review with the aim of deriving a current understanding of: (a) the factors that influence pollen potency; (b) its variation through time, between taxa and by location; and (c) the implications for pollen monitoring practice. Our synthesis found that pollen potency is highly variable within and between seasons, and between locations; however, much of this variability remains unexplained and has not been deeply investigated. We found no predictable pollen potency patterns relating to taxon, geography or time, and inconclusive evidence regarding possible driving factors. With respect to human health, the studies in our synthesis generally reported larger associations between atmospheric allergen loads and allergy symptoms than whole pollen counts. This suggests that pollen potency influences public health risk; however, the evidence base remains limited. Further research is needed to better understand both pollen potency variability and its implications for health.
Unknotting reciprocal causation between organism and environment
Authors: Baedke Jan , Fábregas-Tejeda Alejandro , Prieto Guido I. 
Published: September 2021

AbstractIn recent years, biologists and philosophers of science have argued that evolutionary theory should incorporate more seriously the idea of ‘reciprocal causation.’ This notion refers to feedback loops whereby organisms change their experiences of the environment or alter the physical properties of their surroundings. In these loops, in particular niche constructing activities are central, since they may alter selection pressures acting on organisms, and thus affect their evolutionary trajectories. This paper discusses long-standing problems that emerge when studying such reciprocal causal processes between organisms and environments. By comparing past approaches to reciprocal causation from the early twentieth century with contemporary ones in niche construction theory, we identify two central reoccurring problems: All of these approaches have not been able to provide a conceptual framework that allows (i) maintaining meaningful boundaries between organisms and environments, instead of merging the two, and (ii) integrating experiential and physical kinds of reciprocal causation. By building on case studies of niche construction research, we provide a model that is able to solve these two problems. It allows distinguishing between mutually interacting organisms and environments in complex scenarios, as well as integrating various forms of experiential and physical niche construction.
4D imaging of fetal right ventricle—feasibility study and a review of the literature
Authors: Pasieczna M. , Duliban J. , Grzyb A. , Szymkiewicz-Dangel J. 
Published: September 2021

AbstractFunctional analysis of the fetal cardiovascular system is crucial for the assessment of fetal condition. Evaluation of the right ventricle with standard 2D echocardiography is challenging due to its complex geometry and irregular muscle fibers arrangement. Software package TOMTEC 4D RV-Function is an analysis tool which allows assessment of right ventricular function based on volumetric measurements and myocardial deformation. The aim of this study was to determine the feasibility of this method in fetal echocardiography. The retrospective study was conducted in the high-flow Referral Center for Fetal Cardiology. We recorded 4D echocardiographic sequences of 46 fetuses with normal hearts. Following parameters were calculated: end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF), right ventricle longitudinal free-wall (RVLS free-wall) and septal strain (RVLS septum). Tei index was calculated as a standard measure or RV function for comparison. 4D assessment was feasible in 38 out of 46 fetuses (83%). RV volumetric parameters—EDV, ESV and SV—increased exponentially with gestational age. Functional parameters—RV Tei index, EF and strains—were independent of gestational age. Mean EF was 45.2% (± 6%), RV free-wall strain was − 21.2% and RV septal strain was − 21.5%. There was a statistically significant correlation between septal and free-wall strains (r = 0.51, p = 0.001) as well as between EF and RV free-wall strain (r = − 0.41, p = 0.011). 4D RV assessment is feasible in most fetuses. Its clinical application should be further investigated in larger prospective studies.