bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thromboembolic complications among multiple injured patients with pelvic injuries: identifying risk factors for possible patient-tailored prophylaxis
Authors: Kirchner Tim , Lefering Rolf , Sandkamp Richard , Eberbach Helge , Schumm Klaus , Schmal Hagen , Bayer Jörg ,   TraumaRegister DGU
Published: August 2021

Abstract
Background
Patients with pelvic and/or acetabular fractures are at high risk of developing thromboembolic (TE) complications. In our study we investigate TE complications and the potential negative effects of concomitant pelvic or acetabular injuries in multiple injured patients according to pelvic/acetabular injury severity and fracture classification.

Methods
The TraumaRegister DGU® was analyzed between 2010 and 2019. Multiple injured patients with pelvic and/or acetabular fractures with ISS ≥ 16 suffering from TE complications were identified. We conducted a univariate and multivariate analysis with TE events as independent variable to examine potential risk factors and contributing factors.

Results
10.634 patients met our inclusion criteria. The overall TE incidence was 4.9%. Independent risk factors for the development of TE complications were sepsis, ≥ 10 operative interventions, mass transfusion (≥ 10 PRBCs), age ≥ 65 years and AISAbdomen ≥ 3 (all p < 0.001). No correlation was found for overall injury severity (ISS), moderate traumatic brain injury, additional injury to lower extremities, type B and C pelvic fracture according to Tile/AO/OTA and closed or open acetabular fracture.

Conclusions
Multiple injured patients suffering from pelvic and/or acetabular fractures are at high risk of developing thromboembolic complications. Independent risk factors for the development of thromboembolic events in our study cohort were age ≥ 65 years, mass transfusion, AISAbdomen ≥ 3, sepsis and ≥ 10 surgery procedures. Among multiple injured patients with acetabular or pelvic injuries the severity of these injuries seems to have no further impact on thromboembolic risk. Our study, however, highlights the major impact of early hemorrhage and septic complications on thromboembolic risk in severely injured trauma patients. This may lead to individualized screening examinations and a patient-tailored thromboprophylaxis in high-risk patients for TE. Furthermore, the number of surgical interventions should be minimized in these patients to reduce thromboembolic risk.
Association between dipeptidyl peptidase-4 inhibitors use and leptin in type 2 diabetes mellitus
Authors: Wei Xin , Bai Yu , Wang Zhuo , Zheng Xiaohong , Jin Zening , Liu Xin 
Published: August 2021

AbstractBackgroundDipeptidyl peptidase-4 inhibitors (DPP-4i) provide a unique antihyperglycemic effect by regulating incretin peptides in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled with insulin therapy. The aim of this study was to investigate the impact of DPP-4i on leptin concentrations in subjects with T2DM.MethodsRandomized controlled trials (RCTs) with comparators were systematically searched through PubMed, Embase, and the Cochrane Library. Quantitative analysis was performed with a fixed or random-effects model according to heterogeneity. Publication bias was evaluated by using the standard methods for sensitivity analysis.ResultsTen trials with 698 patients with T2DM were included. Pooled analysis demonstrated that DPP-4i did not significantly change leptin concentrations (1.31 ng/mL, 95 % CI − 0.48 to 3.10). DPP-4i exerted effects on modulating leptin levels compared to active comparators (0.21 ng/mL, 95 % CI − 1.37 to 1.78). Meta-analysis was powerful and stable after sensitivity analysis.ConclusionsDPP-4i did not modulate leptin concentrations in T2DM and exerted no stronger effects than traditional antidiabetic agents.
Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes
Authors: You Sang Youn , Han Kyungdo , Lee Seung-Hawn , Kim Mee Kyoung 
Published: August 2021

Abstract
Background
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases; however, there has been little research into its impact on gestational diabetes mellitus (GDM).

Methods
This study included 308,095 women registered in the Korean National Health Insurance Service database, who delivered between 2011 and 2015 and received a health examination within 52 weeks before pregnancy. Insulin-requiring GDM was defined as no insurance claims for diabetes mellitus and a fasting blood glucose level of < 126 mg/dL before pregnancy, and initiation of insulin treatment during pregnancy. A fatty liver index (FLI) was calculated using body mass index, waist circumference, and blood triglyceride and γ-glutamyl transferase levels. FLI scores < 30 ruled out hepatic steatosis, while FLI scores ≥ 60 indicated NAFLD.

Results
The prevalence of NAFLD was 0.8% (2355/308,095) and 1984 (0.6%) subjects developed insulin-requiring GDM. FLIs of 30–59 and ≥ 60 were significantly associated with increased risk of insulin-requiring GDM (odds ratio [OR] 3.50; 95% confidence interval [CI] 2.99–4.10; OR 4.19; 95% CI 3.37–5.23), respectively. Further exploration of the association of FLI with GDM across FLI decile categories revealed a steady increase in OR across the categories. The association was more prominent among those without metabolic syndrome.

Conclusion
NAFLD in women is an independent risk factor for insulin-requiring GDM.
Characterization of a novel cysteine protease in Trichinella spiralis and its role in larval intrusion, development and fecundity
Authors: Hu Yuan Yuan , Zhang Ru , Yan Shu Wei , Yue Wen Wen , Zhang Jia Hang , Liu Ruo Dan , Long Shao Rong , Cui Jing , Wang Zhong Quan 
Published: August 2021

AbstractThe aim of this study was to investigate the biological properties of a novel gut-specific cysteine protease in Trichinella spiralis (TsGSCP) and its role in larval intrusion, development and fecundity. TsGSCP has a functional C1 peptidase domain; C1 peptidase belongs to cathepsin B family. The TsGSCP gene cloned and expressed in Escherichia coli BL21 showed intensive immunogenicity. qPCR and Western blotting revealed that TsGSCP mRNA and protein were expressed at various T. spiralis stages, but their expression levels in intestinal infectious larvae (IIL) were clearly higher than those in muscle larvae (ML), adult worms (AWs) and new-born larvae (NBL). Indirect immunofluorescence (IIF) analysis showed that TsGSCP was primarily located at the outer cuticle and the intrauterine embryos of this parasite. rTsGSCP showed the ability to specifically bind with IECs, and the binding site is within the IEC cytoplasm. rTsGSCP accelerated larval intrusion into host intestinal epithelial cells (IECs), whereas anti-rTsGSCP antibodies suppressed larval intrusion; the acceleration and suppression was induced by rTsGSCP and anti-rTsGSCP antibodies, respectively, in a dose-dependent manner. When ML were transfected with TsGSCP-specific dsRNA, TsGSCP expression and enzymatic activity were reduced by 46.82 and 37.39%, respectively, and the capacity of the larvae to intrude into IECs was also obviously impeded. Intestinal AW burden and adult female length and fecundity were significantly decreased in the group of mice infected with dsRNA-transfected ML compared to the control dsRNA and PBS groups. The results showed that TsGSCP plays a principal role in gut intrusion, worm development and fecundity in the T. spiralis lifecycle and might be a candidate target for vaccine development against Trichinella intrusion and infection.
The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules
Authors: Archibald Stephen J. , Allott Louis 
Published: August 2021

AbstractThe aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.
Geopolitics of Comparison: World LiteratureAvant la Lettre
Authors: Hassan Waïl S. 
Published: August 2021

AbstractAccording to a well-known narrative, the concept of Weltliteratur and its academic correlative, the discipline of comparative literature, originated in Germany and France in the early nineteenth century, influenced by the spread of scientism and nationalism. But there is another genesis story that begins in the late eighteenth century in Spain and Italy, countries with histories entangled with the Arab presence in Europe during the medieval period. Emphasizing the role of Arabic in the formation of European literatures, Juan Andrés wrote the first comparative history of “all literature,” before the concepts of Weltliteratur and comparative literature gained currency. The divergence of the two genesis stories is the result of competing geopolitical interests, which determine which literatures enter into the sphere of comparison, on what terms, within which paradigms, and under what ideological and discursive conditions.
On the Translatability of Cultural Phenomena: Modernismo and Modernism within and without Mass Culture
Authors: Herzovich Guido 
Published: August 2021

Abstract
“Spanish American modernismo,” wrote Octavio Paz in 1972, “has no connection to what in English is called ‘modernism.’” Indeed, for a long time there was consensus in both critical traditions that “despite some parallels,” as Astradur Eysteinsson put it, “the differences between the two concepts are too many to warrant their critical coalescence.” In recent years, however, it has become the rule to discuss Latin American and Spanish modernismos within the Anglo-Germanic notion of modernism, as part of the broader concept of “global modernisms.” But how did two of the most important aesthetic concepts of the twentieth century from two distinct traditions go from misleading cognates to variants of the same phenomenon? This article offers a comparative history to explain the conditions of their mutual (un)translatability. It presents their divergent beginnings, briefly surveys their independent developments, and finally argues that, in the past few decades, both have similarly turned from differential to relational concepts mainly by transforming their relationship to mass culture. They have thus gone from high-literary ideologies of exclusion to fields of research on the networks and dynamics of modern culture. As they did, however, their standing within their respective critical traditions has changed in opposite ways.
Efficiency of Human Resource Management in the Context of Covid-2019
Authors: Kuz'minova T. 
Published: August 2021

The main problem of social and labor relations in the context of COVID-2019 is the rise in unemployment. The article shows that an orientation towards the future forces us to pay attention not only to the preservation of the quantitative characteristics of human resources, but also to the efficiency of management of the most important factor of production for any enterprise “labor”.
According to the Federal State Statistics Service, the dynamics of growth in labor productivity and growth in wages in the Russian economy have been built. The analysis showed that the COVID-2019 pandemic, having influenced the economies of all countries, did not fundamentally change the efficiency of human resource management, but created the conditions for its qualitative transformation.
To ensure the long-term competitiveness of socio-economic systems in a changing environment, HR specialists are faced with the task of adequately assessing the ongoing changes and the appropriate transformation of human resource management systems.
A General Model and Efficient Algorithms for Reliable Facility Location Problem Under Uncertain Disruptions
Authors: Li Yongzhen , Li Xueping , Shu Jia , Song Miao , Zhang Kaike 
Published: August 2021

This paper studies the reliable uncapacitated facility location problem in which facilities are subject to uncertain disruptions. A two-stage distributionally robust model is formulated, which optimizes the facility location decisions so as to minimize the fixed facility location cost and the expected transportation cost of serving customers under the worst-case disruption distribution. The model is formulated in a general form, where the uncertain joint distribution of disruptions is partially characterized and is allowed to have any prespecified dependency structure. This model extends several related models in the literature, including the stochastic one with explicitly given disruption distribution and the robust one with moment information on disruptions. An efficient cutting plane algorithm is proposed to solve this model, where the separation problem is solved respectively by a polynomial-time algorithm in the stochastic case and by a column generation approach in the robust case. Extensive numerical study shows that the proposed cutting plane algorithm not only outperforms the best-known algorithm in the literature for the stochastic problem under independent disruptions but also efficiently solves the robust problem under correlated disruptions. The practical performance of the robust models is verified in a simulation based on historical typhoon data in China. The numerical results further indicate that the robust model with even a small amount of information on disruption correlation can mitigate the conservativeness and improve the location decision significantly. Summary of Contribution: In this paper, we study the reliable uncapacitated facility location problem under uncertain facility disruptions. The problem is formulated as a two-stage distributionally robust model, which generalizes several related models in the literature, including the stochastic one with explicitly given disruption distribution and the robust one with moment information on disruptions. To solve this generalized model, we propose a cutting plane algorithm, where the separation problem is solved respectively by a polynomial-time algorithm in the stochastic case and by a column generation approach in the robust case. The efficiency and effectiveness of the proposed algorithm are validated through extensive numerical experiments. We also conduct a data-driven simulation based on historical typhoon data in China to verify the practical performance of the proposed robust model. The numerical results further reveal insights into the value of information on disruption correlation in improving the robust location decisions.
Persepsi Generasi Z Terhadap Pengaruh Media Sosial dalam Intensi Pembelian Makanan Vegetarian ala Korea Pada Bisnis Rice Bowl In.yo
Authors: Genady Marcella Amanda , Michellita Cynthia 
Published: August 2021

Pesatnya perubahan tren makanan dan minuman menjadi tantangan besar bagi industri kuliner. Dengan adanya pandemi COVID-19, mulai muncul tren makanan vegetarian dan makanan sehat, selain itu makanan Korea juga kian digemari oleh Generasi Z. Penelitian ini bermaksud untuk mengetahui persepsi Generasi Z khususnya konsumen In.yo, sebuah bisnis lokal bertemakan Korea yang menyediakan berbagai varian makanan dengan protein nabati yang diolah dengan cita rasa ala Korea, terhadap pengaruh media sosial dalam intensi pembelian makanan vegetarian ala Korea, meskipun konsumen tidak menjalankan pola hidup vegetarian jenis apapun. Penelitian dilakukan secara daring pada 4 (empat) konsumen In.yo di kota Surabaya, Jombang, dan Samarinda. Dari penelitian ini dapat disimpulkan bahwa Generasi Z meskipun memiliki pengetahuan yang sangat rendah mengenai jenis-jenis vegetarian maupun protein nabati sebagai alternatif daging, memiliki intensi pembelian makanan vegetarian ala Korea karena rasa penasaran ingin mencoba karena melihat iklan yang ada di media sosial, ingin menurunkan berat badan,serta karena harga yang lebih murah dibandingkan dengan menu berprotein daging ayam. Sehingga usaha In.yo untuk mengedukasi Generasi Z mengenai pola makan vegetarian melalui media sosial, serta menyediakan pilihan makanan vegetarian memiliki pengaruh besar untuk mengubah persepsi Generasi Z terhadap makanan vegetarian ala Korea.
Isolation, identification, and analysis of the invertase-producing bacteria abundance in sugarcane rhizosphere soil with different plant productivity levels
Authors: Lase Ester Raisa K. , Giyanto Giyanto , SANTOSA DWI ANDREAS 
Published: August 2021

Abstract. Lase ERK, Giyanto Santosa DA. 2021. Isolation, identification, and analysis of the invertase-producing bacteria abundance in sugarcane rhizosphere soil with different plant productivity levels. Biodiversitas 22: 3156-3162. microbes and enzymes play an important role in maintaining the stability of soil ecosystems. Invertase is one of the soil enzymes produced by microbes to hydrolyze sucrose in the environment. The aims of this study were to investigate the abundance of invertase-producing bacteria and soil invertase activity in sugarcane rhizosphere soil with different plant productivity levels and their correlation with soil chemical and physical properties and to obtain invertase-producing bacteria from the sugarcane rhizosphere. The samples of sugarcane rhizosphere soil were collected using a randomized sampling method and determine their physical-chemical properties, the abundance of invertase-producing bacteria, and soil invertase activity. Twenty invertase-producing bacteria were successfully isolated and tested their abilities to produce invertase qualitatively and quantitatively. The three best isolates (ScT112, ScT124, and ScR301) were molecularly identified using the 16S rRNA gene and phylogenetic tree analysis. The results of this study indicate that there is a significant correlation between invertase bacterial abundance and soil invertase activity. The abundance of invertase-producing bacteria correlates with pH, organic C, total N, and soil sand content. Invertase activity in the soil correlates with pH and organic C. Based on the phylogenetic tree, the isolates of ScT112 had the closest homology with Cupriavidus sp., ScT124 was homologous with Klebsiella variicola, while ScR301 was homologous with Pantoea sp. These three isolates have the potential to be developed in industrial biotechnology to produce invertase. The hydrolysis zones of ScT112, ScT124, and ScR301 were 3.12 cm, 2.76 cm, and 2.55 cm, respectively with the invertase activity of 27.82 U mL-1, 24.56 U mL-1, and 24.08 U mL-1.
Population genetics analysis of Phytophthora nicotianae associated with heart rot in pineapple revealed geneflow between population
Authors: Afandi Auliana , Subandiyah Siti , Wibowo Arif , Hieno Ayaka , AFANDI Afandi , Loekito Supriyono , Suga Haruhisa , Kageyama Koji 
Published: August 2021

Abstract. Afandi A, Subandiyah S, Wibowo A, Hieno A, Afandi, Loekito S, Suga H, Kageyama K. 2021. Population genetics analysis of Phytophthora nicotianae associated with heart rot in pineapple revealed gene flow between populations. Biodiversitas 22: 3342-3348. Phytophthora nicotianae has caused heart rot in pineapple. This study identified the population genetic diversity of P. nicotianae, collecting 90 isolates of P. nicotianae from the pineapple plantation sites in three provinces of Indonesia and, as comparisons, seven isolates from non-pineapple sites. Six polymorphic microsatellite markers amplified the non-coding region was used to characterize the population diversity. The phylogenetic tree constructed by MEGA revealed three major clades; the first and second clades were dominated by the isolates from pineapple plantation sites, and the third clade contained isolates from the non-pineapple sites. The allelic pattern analysis using Genalex software revealed the local alleles specific to Lampung and Blitar populations. The AMOVA of microsatellite genotypes data showed that the isolates had a low diversity among the population (6%) but high diversity within individual. Conclusively, P. nicotianae population associated with heart rot in pineapple showed geneflow between populations.
Tannins in mangrove plants in Segara Anakan Lagoon, Central Java, Indonesia
Authors: Hilmi Endang , Sari Lilik Kartika , Siregar Asrul Sahri , Sulistyo Isdy , Mahdiana Arif , Junaedi Teuku , Muslih MUSLIH , Pertiwi Rika Prihati Cahyaning , Samudra Sesilia Rani , Prayogo Norman Arie 
Published: August 2021

Abstract. Hilmi E, Sari LK, Siregar AS, Sulistyo I, Mahdiana A, Junaedi T, Muslih, Pertiwi RPC, Samudra SR, Prayogo NA. 2021. Tannins in mangrove plants in Segara Anakan Lagoon, Central Java, Indonesia. Biodiversitas 22: 3508-3516. Mangrove tannin is polyphenol compound and extractive matter in mangrove vegetation. Mangrove tannins have the potentials to support paint industry, animal feed, tanners and wood adhesives industry. This research is aimed to investigate the mangrove species in Segara Anakan, Central Java, Indonesia that produce tannins, and to analyze the distribution and contents of tannin in the part of mangrove plant. A total of 342 samples from 19 mangrove species was collected from 37 sampling points in Segara Anakan. UV-Visible Spectrophotometry was used to analyze the tannin content in the samples. The results showed that the tannins contained in bark and stems were higher (66.6%) than those in leaves (33.4%). Mangrove vegetation can be classified into five classes in terms of tannin percentage with Heritiera littoralis, Nypa fruticans, and Rhizophora mucronata had highest tannin percentage. The clustering analysis of mangrove tannin showed that Ceriops decandra-Ceriops tagal, Acacia auriculiformis-Sonneratia alba, Sonneratia caseolaris-Xylocarpus granatum, and Avicennia marina-Rhizophora apiculata had high similarity of tannin percentage. The distribution of tannins in mangrove species is as follow: 0.59-10.14 kg trees-1 (bark and stem of mangrove diameter > 10 cm) and 0.20-3.74 kg trees-1 (leaves of mangrove diameter > 10 cm) until 8.84-158.96 kg trees-1 (bark and stem of mangrove diameter > 40 cm) and 4.60-91.65 kg trees-1 (leaves of mangrove diameter > 40 cm). R. mucronata and R. apiculata had the highest total tannin content, ranged between 386.60-460.38 kg trees-1.
Clinical characteristics, treatment strategies and oncologic outcomes of primary retroperitoneal tumours: a retrospective analysis in the Chinese population
Authors: Xu J , Cheng R , Ou L , Wei Z , Wang Y , Cui L , Shi B 
Published: August 2021

Introduction Primary retroperitoneal tumours (PRTs) are rare soft tissue tumours originating from the retroperitoneum. Although there has been considerable progress recently in diagnosis and treatment, the overall survival rate has not improved qualitatively. This study aimed to explore the clinical features, therapeutic strategies and prognosis of PRTs. Methods Retrospective analysis of clinical data for 121 PRT patients admitted to Peking University Shenzhen Hospital from April 2003 to February 2017. Results A total of 113 patients underwent surgery and 8 chose nonsurgical palliative treatment. There were 53 males and 68 females (ratio, 1:1.3; average age, 40.75 years), and the average tumour diameter was 9.69(2–40)cm. A total of 104 patients (92.04%) underwent complete resection, 5 (4.42%) underwent palliative resection and 21 (18.58%) underwent combined visceral resection. The pathological diagnosis was benign in 88 cases (72.73%) and malignant in 33 cases (27.27%). A total of 101 patients (83.47%) were followed for an average of 5.82 years. At the end of follow up, the recurrence and survival rates were 2.63% and 93.42% for benign tumours, respectively, and 24.00% and 60.00% for malignant tumours (p<0.01). Conclusions Imaging plays important roles in localising and characterising tumours, guiding treatment strategies. Complete tumour resection is key to reducing postoperative recurrence and improving survival. According to the postsurgical pathological results, combinations including radiotherapy, chemotherapy or targeted therapy are beneficial for improving prognosis.