bluuebunny/crossref_metadata_2025_split huggingface dataset:
European River Lamprey Lampetra Fluviatilis in the Upper Volga: Distribution and Biology
Authors: Zvezdin Aleksandr , Kucheryavyy Aleksandr , Kolotei Anzhelika , Polyakova Natalia , Pavlov Dmitrii 
Published: February 2021

Abstract
After the construction of the Volga Hydroelectric Station and other dams, migration routes of the Caspian lamprey were obstructed. The ecological niches vacated by this species attracted another lamprey of the genus Lampetra to the Upper Volga, which probably came from the Baltic Sea via the system of shipways developed in the 18 th and 19 th centuries. Based on collected samples and observations from sites in the Upper Volga basin, we provide diagnostic characters of adults, and information on spawning behavior. Silver coloration of Lampetra fluviatilis was noted for the first time and a new size-related subsample of “large” specimens was delimited, in addition to the previously described “dwarf”, “small” and “common” adult resident sizes categories. The three water systems: the Vyshnii Volochek, the Tikhvin and the Mariinskaya, are possible invasion pathways, based on the migration capabilities of the lampreys. Dispersal and colonization of the Caspian basin was likely a combination of upstream and downstreams migrations. First, the lampreys migrated upstream along the rivers of the Baltic basin until they reached the water-parting line, followed by mostly downstream dispersal into rivers of the Caspian basin. Dispersal in the Volga River was similar, in accordance with the migration cycle of this opportunistic lamprey species.
The Effects of Educational Intervention on Operating Room Nurses' Application of Electrosurgical Units
Authors: Fereidouni Armin , Amiri Mina , Bijani Mostafa , Moayedi Seyed Alireza , Torabizadeh Camellia 
Published: February 2021

Abstract
Background: An electrosurgical unit is one of the most essential pieces of equipment in operating rooms. Over 80% of operations today make use of electrosurgical units. Training operating room nurses in correct application of electrosurgical units and evaluation of their application play a key role in making optimal use of the units and extending their lifetime, reducing occupational hazards for surgical teams, and enhancing the safety of patients. The present study aims to investigate the effects of an educational intervention on operating room nurses' application of electrosurgical units. Methods: The present study is a quasi-experimental work of research conducted in all the operating rooms of the hospitals located in Shiraz, Iran. Data were collected from 200 observations of 200 surgeries (100 before intervention and 100 after). The content of education was derived from a literature review and standard guidelines and was presented as a poster in the operating rooms. The data collection instruments consisted of a Demographic Information Questionnaire, a surgery checklist, and the checklist for operating room Nurses' application of electrosurgical units. Data were collected once before the intervention and then again one month after the intervention. The collected data were analyzed using the descriptive statistics of chi-square test and paired t-test at a significance level of 0.05 in SPSS v. 18.Results: The average age of the participating nurses was 31.540±6.772 years. The majority of the participants were female. The results showed a statistically significant difference between the means and standard deviations of the nurses' application of electrosurgical units scores before (18.330±2.666) and after (20.820±3.400) intervention. Conclusion: Introducing operating room nurses to the standard guidelines for application of electrosurgical units can improve the quality of services provided by the nurses, increase the safety of patients, and reduce occupational hazards. Thus, to improve operating room nurses' professional performance in application of electrosurgical units, medical managers and policy-makers should attach more importance to on-the-job training programs.
What Is the Optimal Timing of Thawing for Transferring Vitrified-warmed Cleavage Stage of Slow-growing Embryos? A Cohort Retrospective Study
Authors: Geng Lan , Wu Jia-hui , Luo Jia-qi , Shi Yu , Qian Wei-ping , Kallen Amanda , Xia Xi 
Published: February 2021

Abstract
PurposeTo evaluate optimal thawing time, the early thawing or the routine thawing time, for transferring vitrified-warmed, and cultured overnight cleavage stage of the slow-growing embryos on Day 3 in frozen embryo transfer (FET) cycle. MethodsThis was a retrospective cohort study from January 2017 to July 2018, a total of 705 slow-growing embryos FET cycles in which the patients were aged <40. Thawing cleavage stage slow-growing Day 3 embryos on either the 2nd or 3rd day after ovulation in natural cycle or the equivalent timing of the artificial cycles. ResultsFor slow growing embryos, the clinical pregnancy rate of early thawing group (152/468 (32.5%)) was significantly higher than that of routine thawing group (55/235 (23.4%)) (OR 1.39(CI 1.06-1.81), p=0.01), while there was no statistically significant difference in pregnancy loss in early thawing group (39/170 (22.9%)) versus in routine thawing group (16/62 (25.8%)) (OR 0.89 (CI 0.53-1.47), p =0.65). ConclusionFor slow-growing embryos, higher pregnancy outcomes were shown in early thawing strategy as compared to the routine thawing, which suggested that the improvement of endometrium-embryo synchronism may correct the time difference brought by the slow-growing embryos.
Excessive Iodine Induces Thyroid Follicular Epithelial Cells Apoptosis by Activating HIF-1α-mediated Hypoxia Pathway in Hashimoto Thyroiditis
Authors: zhang lili , Liu Lin , Wang Ping , Qian Linxue 
Published: February 2021

Abstract
Purpose Hashimoto thyroiditis (HT) is considered the most common autoimmune thyroid disease. A growing body of evidence suggests that HT incidence correlates with excessive iodine intake. We should probe the effects of excessive iodine intake in HT development and its possible mechanism. Methods The study recruited 20 patients: 10 with HT and 10 with nodular goiter. We detected the expression of an apoptosis-related protein caspase-3 by immunohistochemistry. In vitro study, we explored the proliferation and apoptosis status in thyroid follicular cells (TFCs) stimulated at different iodine concentrations by MTT and flow cytometry. Then we performed RNA sequence analysis of Nthy-ori3-1 cells treated for 48h with different KI concentrations to probe the underlying mechanism. Finally, we used RT-PCR to verify its results. Results We identified apoptosis in thyroid tissue obtained from HT patients coincides with the increase of caspase-3 levels. In vitro study, iodine suppressed proliferation of TFCs and promoted TFCs apoptosis in a dose-dependent manner. RNA sequence results showed that high concentration of iodine activate the hypoxia-inducible factor-1α (HIF-1α)-mediated hypoxia pathway coincide with the upregulation of N-myc downregulated gene-1 (NDRG1) expression. Conclusions Our study confirmed that excessive iodine adsorption activates the HIF-1α-mediated hypoxia pathway to promote apoptosis of TFCs, which may be an important risk factor contributing to HT development.
Psychometric Properties of Instruments to Measure Parenting Practices and Children's Movement Behaviors in Low-income Families From Brazil
Authors: Goncalves Widjane Sheila Ferreira , Byrne Rebecca , Lira Pedro Israel Cabral , Viana Marcelo Tavares , Trost Stewart 
Published: February 2021

Abstract
Background: Childhood obesity has increased remarkably in low and middle-income (LMIC) countries. Movement behaviors (physical activity, screen time, and sleep) are crucial in the development of overweight and obesity in young children. Yet, few studies have investigated the relationship between children´s movement behaviors and parenting practices because validated measures for use among families from LMIC are lacking. This study evaluated the psychometric properties of previously validated measures of young children’s physical activity, screen time, and sleep and parenting practices, translated and culturally adapted to Brazilian families. Methods: A total of 78 parent-child dyads completed an interviewer-administered survey twice within 7 days. Child physical activity, sedentary time and sleep were concurrently measured using a wrist-worn accelerometer. Internal consistency and test-retest reliability was assessed using Cronbach’s alpha and Intraclass Correlation Coefficients (ICC’s). Concurrent validity was evaluated by calculating Spearman correlations between parent reported child behaviors and accelerometer measured behaviors. Results: Parenting practices scales exhibited acceptable internal consistency with alpha coefficients ranging from 0.66 - 0.88. Test-retest reliability ICC’s were acceptable and ranged from 0.82 - 0.99. Parent reported child physical activity was positively correlated with objectively measured total movement (rho= 0.29 - 0.46, p < .05) and energetic play (rho=0.29 – 0.40, p < .05). Parent reported child screen time was positively correlated with objectively measured sedentary time; (rho = 0.26, p < .05), and inversely correlated with total movement (rho = - 0.39 – - 0.41, p < .05) and energetic play (rho = - 0.37 – - 0.41, p < .05). Parent reported night-time sleep duration was significantly correlated with accelerometer measured sleep duration on weekdays (rho = 0.29, p < .05), but not weekends. Conclusions: Measurement tools to assess children’s movement behaviors and parenting practices, translated and culturally adapted for use in Brazilian families, exhibited acceptable evidence of concurrent validity, internal consistency, and test-retest reliability.
Effect of Micro Textures on the Cutting Performance of Circular Saw Blade Under Fluid Lubrication
Authors: Lu Yang , Deng JIanxin , sun Qinghao , Ge Dongliang , Wu Jiaxing , Zhang Zhihui 
Published: February 2021

Abstract
In this paper, linear micro textures that parallel to the sawtooth edge were fabricated on the surface of the high speed steel W6Mo5Cr4V2 circular saw blade by laser engraving. Further, cutting performance of micro textured circular saw blade (TCS) and traditional circular saw blade (CS), including sawing arc length, sawing force, sawing temperature, machined surface roughness and wear mechanism, were investigated in sawing 304 stainless steel pipes under the cutting fluid condition. Results showed that the largest sawing arc length and sawing force were occurred on the circular saw blade sawing outward from the inner wall. In addition, TCS circular saw blade exhibited better cutting performance and the mechanisms were found, on the one hand, the effective sawtooth-chip contact length was reduced due to the micro textures fabricated on the sawtooth surface, on the other hand, cutting fluid can be better penetrated into the micro textures and formed stable lubrication film in sawtooth-chip contact interface.
Implementation of Targeted Screening for Poverty in a Large Primary Care Team in Toronto, Canada: A Feasibility Study
Authors: Wintemute Kimberly , Noor Meh , Bhatt Aashka , Bloch Gary , Arackal Suja , Kalia Sumeet , Aliarzadeh Babak , Tona Sabrina La , Lo Joyce , Pinto Andrew , Greiver Michelle 
Published: February 2021

Abstract
BackgroundPoverty has a significant influence on health. Efforts to optimize income and reduce poverty could make a difference to the lives of patients and their families. Routine screening for poverty in primary care is an important first step but rarely occurs in Canada. We aimed to implement a targeted screening and referral process in a large, distributed primary care team in Toronto, Ontario, Canada.MethodsThis implementation evaluation was conducted with a large community-based primary care team in north Toronto. The primary care team serves relatively wealthy neighborhoods that contain pockets of poverty. Physicians were invited to participate. We implemented targeted screening by combining census information on neighborhood-level deprivation with postal codes in patient records. For physicians agreeing to participate, we added prompts to screen for poverty to the charts of adult patients living in the most deprived areas. Standardized electronic medical record templates recommended a referral to a team case worker for income optimization, for those patients screening positive. We recorded the number and percentages of participants at each stage, from screening to receiving advice on income optimization. ResultsThe primary care team included 86 physicians distributed across 19 clinical locations. Thirty-four physicians (39%) participated. Their practices provided care for 27,290 patients aged 18 or older; 852 patients (3%) were found to be living in the most deprived neighborhoods. 509 (60%) had at least one office visit over the 6 months of follow up, and 128 (25%) of those seen were screened. Only 25 (20%) of these patients screened positive for poverty, and 13 (52%) were referred. Eight patients (62% of those referred) were ultimately seen by a caseworker for income optimization.Discussion & ConclusionsWe implemented a targeted poverty screening program combined with resources to optimize income for patients in a large, distributed community-based primary care team. However, only a small number of patients were identified and linked to the intervention Further efforts to scale and spread screening and mitigation of poverty are warranted; these should include broadening the targeted population beyond those living in the most deprived areas.
Tailoring Nano-copolymer/CNTs Composite and Its Application in Drug Delivery
Authors: Darwish M. K. , Said M. S. , El-Sayed A. A. , Sobh R. A. , Khalek A. A. Abdel 
Published: February 2021

Abstract
This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these ground-breaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.
Recovery-oriented practices and role perceptions of healthcare staff providing community-based mental healthcare as team in Central and Eastern Europe: an observational study
Authors: Roth Catharina , Wensing Michel , Kuzman Martina Rojnic , Bjedov Sarah , Medved Sara , Istvanovic Ana , Grbic Danijela Stimac , Pavic Ivana , Tomcuk Aleksander , Dedovic Jovo , Djurisic Tatijana , Nica Raluca Ileana , Rotaru Tiberiu , Novotni Antoni , Bajraktarov Stojan , Milutinovic Milos , Nakov Vladimir , Zarkov Zahari , Dinolova Roumyana , Walters Bethany Hipple , Shields-Zeeman Laura , Petrea Ionela 
Published: February 2021

Abstract
Background: CMHTs deliver healthcare that supports the recovery of people with mental illness. They should achieve a sufficient level of good quality teamwork, composed of individual professional skills as well their adaptation within the clearly defined roles in teams in order to work efficiently. This paper analyses to what extent team members of five CMHTs newly implemented in five countries had introduced aspects of the recovery-oriented approach and evaluates what the team members’ perceptions on their collaborative care roles and their level of confidence with this role are.Method: A quantitative survey was administered among 66 professionals and peer worker including the Recovery Self-Assessment Tool Provider Version (RSA-P), the Team Member Self-Assessment Tool (TMSA), and demographic questions. Result: The RSA-P showed that all teams had the perception that they provide recovery–oriented practice to a moderately high degree after a training week on recovery-oriented care. Healthcare providers with fewer years of professional experience perceived more frequently that they operated in a recovery-oriented way (p=0.036, B -0.268). Nurses and peer workers did not feel confident or responsible to fulfil specific roles.Conclusion: Trainings on community-based practices and collaborative teamwork may facilitates recovery-oriented care and helps to improve team cohesion. Trial registration: Each trial was registered before participant enrolment in the clinicaltrials.gov database: Croatia, Zagreb (Trial Reg. No. NCT03862209); Montenegro, Kotor (Trial Reg. No. NCT03837340); Romania, Suceava (Trial Reg. No. NCT03884933); Macedonia, Skopje (Trial Reg. No. NCT03892473); Bulgaria, Sofia (Trial Reg. No. NCT03922425)
Salivary protein glycopatterns for natural regulation of oral microbiota
Authors: Li Zheng , Shu Jian , Hanjie Yu , Wang Yan , Ren Xiameng , Zhang Kun , Tang Zhen , Chen Wentian , Li Baozhen 
Published: February 2021

Abstract
The oral microbiota is the direct precursor of dental caries and periodontitis, which are the most common microbial-induced diseases worldwide. The distinct microenvironment at the oral barrier breeds unique microbial communities, which are regulated by host factors (inflammation or dietary sugars)1. Increasing evidence indicates that dysbiosis of oral microbial communities is associated with many human diseases2-5. Our studies demonstrated that human disease could induce different alterations in salivary protein glycopatterns6. However, the relationship between salivary protein glycopatterns and oral microbial communities is unknown. Here, we report that altered salivary protein glycopatterns, namely, fucosylated or sialylated structures induced by gastric cancer (GC) or type 2 diabetes mellitus (T2DM), respectively, are also drivers of dysbiosis of oral microbial communities and ultimately dental caries and periodontitis. The fucosylated neoglycoproteins and sialic acid (SA) α2-3 galactose (Gal) structure can inhibit the growth or/and adhesion of Aggregatibacter segnis and Candida albicans from the oral cavity of patients with GC and T2DM, respectively. These findings provide a novel theory that dynamic communities of oral microbiota are regulated naturally by host salivary protein glycopatterns, having important implications for developing new carbohydrate drugs for oral and body health.
Using an online CBT-based intervention to improve academic performance in students with low mood: A pre-post study with historical control
Authors: Awadalla Suheir , Davies Bethan , Glazebrook Cristine 
Published: February 2021

Abstract
Background

Online CBT-based interventions have shown potential to improve mental health in university students. However, their impacts in West Asian cultures and on educational achievement have yet to be fully investigated. This study aims to explore the feasibility, acceptability and potential effectiveness of a self-directed, internet-delivered, cognitive-behavioural skills training program (MoodGYM) in reducing depression and improving academic performance in university students in the United Arab Emirates (UAE).
Methods

This exploratory pre-post intervention study with an historic control group recruited 50 students from one UAE university, with GPA < 2 and self-reporting at least one of two key depressive symptoms. Pre-intervention, participants completed an online survey including most recent grade point average (GPA), number of attendance warnings and the Hospital Anxiety and Depression Scale (HADS). Participants were then sent a link to MoodGYM. After eight weeks, 44 participants repeated the survey and provided feedback on MoodGYM (88% follow-up). A subgroup of 19 students with GPA scores < 2 at baseline formed an historical control group for change in GPA and attendance warnings.
Results

Total HADS-Depression scores fell at post intervention (P = 0.004) and the proportion of participants scoring above the cut-off for depression (HADS-D ≥ 8) fell from 77.2–27.3% (p < 0.001). There was also a substantial fall in HADS-Anxiety scores (p < 0.001) and the proportion of participants above the cut-off for anxiety (HADS-A ≥ 8) fell from 50% to 11.4 % (p = 0.001). GPA scores improved substantially over time (p < 0.001, d = 1.3) and attendance warnings reduced (p = 0.008, d = 0.6). Compared to historic control, the intervention group had higher GPA at follow-up (p < 0.030 d = 0.6) fewer attendance warnings (p = 0.036 d = 0.7). Most students (79.6%) evaluated MoodGYM as useful and all students completed at least 2 MoodGYM modules. More modules completed (p = 0.005) and greater reduction in attendance warnings (p = 0.007) were independently associated with greater improvement in GPA scores at follow-up.
Conclusions

This study provides support for a web based mental health promotion intervention (MoodGYM) to improve academic achievement in university students with depressive symptoms. Further research is needed to explore how MoodGYM can be best implemented within University settings.
Post-operative Uric Acid: A Predictor for 30-days Mortality of Acute Type A Aortic Dissection Repair
Authors: Xu Qian , Ma Shulun , Hu Qinghua , Huang Lingjin , Wu Dongkai , Chen Xuliang , Lin Guoqiang , Luo Wanjun 
Published: February 2021

Abstract
Background: Hyperuricemia is associated with aortic dissection and cardiovascular diseases. The implication of high serum uric acid (UA) level after acute aortic dissection repair remains unknown. The aim of this study is to explore the role of peri-operative serum UA level in predicting 30-days mortality with acute type A aortic dissection (AAAD) patients, who underwent surgery. Methods and Results: 209 consecutive AAAD patients were included, 14.3% (n=30) were dead within 30 days after surgery. By univariate analysis, we found AAAD repair patients with 30-days mortality had a higher prevalence of cerebral malperfusion, lower pre-operative fibrinogen, longer cardiopulmonary bypass and aortic crossclamp time, and higher post-operative day 1 (POD1) creatinine and urea levels. Both pre-operative (433.80±152.59 vs. 373.46±108.31mmol/L, P=0.038) and POD1 (559.78±162.23 vs. 391.29±145.19 mmol/L, P=0.000) UA level were higher in mortality group than in survival group. In regression model, only cerebral malperfusion (OR, 7.937, 95% CI, 1.252-50.323; P=0.028) and POD1 UA level (OR, 1.006; 95% CI, 1.003-1.009; P=0.000) were independent predictors of 30-days mortality in AAAD repair patients. According to the ROC curve, the POD1 UA level provided positive value for 30-days mortality in AAAD repair patients with 0.799 areas under the curve. The optimum cutoff value selected by ROC curve was 500.15 mmol/L, with a sensitivity of 69.2% and a specificity of 81.7%. Conclusion: Pre- and post-operative hyperuricemia are potentially associated with worsened outcomes in AAAD surgery patients. The POD1 UA level has a predictive role in 30-days mortality in AAAD repair patients.