bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Dysfunction of Glymphatic System in Patients With Glioma
Authors: Toh Cheng Hong , Siow Tiing Yee 
Published: September 2021

ObjectivesRodent experiments have provided some insights into the changes of glymphatic function associated with glioma growth. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method offers an opportunity for the noninvasive investigation of the glymphatic system in patients with glioma. We aimed to investigate the factors associated with glymphatic function changes in patients with glioma.Materials and MethodsA total of 201 glioma patients (mean age = 47.4 years, 116 men; 86 grade II, 52 grade III, and 63 grade IV) who had preoperative diffusion tensor imaging for calculation of the ALPS index were retrospectively included. Information collected from each patient included sex, age, tumor grade, isocitrate dehydrogenase 1 (IDH1) mutation status, peritumoral brain edema volume, tumor volume, and ALPS index. Group differences in the ALPS index according to sex, tumor grade, and IDH1 mutation status were assessed using analysis of covariance with age adjustment. Linear regression analyses were performed to identify the factors associated with the ALPS index.ResultsGroup comparisons revealed that the ALPS index of grade II/III gliomas was significantly higher than that of grade IV gliomas (p &lt; 0.001). The ALPS index of IDH1 mutant gliomas was significantly higher than that of IDH1 wild-type gliomas (p &lt; 0.001). On multivariable linear regression analysis, IDH1 mutation (β = 0.308, p &lt; 0.001) and peritumoral brain edema volume (β = −0.353, p &lt; 0.001) were the two independent factors associated with the ALPS index.ConclusionIDH1 wild-type gliomas and gliomas with larger peritumoral brain edema volumes were associated with a lower ALPS index, which may reflect impaired glymphatic function.
Active Fraction Combination From Liuwei Dihuang Decoction Improves Adult Hippocampal Neurogenesis and Neurogenic Microenvironment in Cranially Irradiated Mice
Authors: Wei Mingxiao , Feng Shufang , Zhang Lin , Wang Chen , Chu Shasha , Shi Tianyao , Zhou Wenxia , Zhang Yongxiang 
Published: September 2021

Background: Cranial radiotherapy is clinically used in the treatment of brain tumours; however, the consequent cognitive and emotional dysfunctions seriously impair the life quality of patients. LW-AFC, an active fraction combination extracted from classical traditional Chinese medicine prescription Liuwei Dihuang decoction, can improve cognitive and emotional dysfunctions in many animal models; however, the protective effect of LW-AFC on cranial irradiation–induced cognitive and emotional dysfunctions has not been reported. Recent studies indicate that impairment of adult hippocampal neurogenesis (AHN) and alterations of the neurogenic microenvironment in the hippocampus constitute critical factors in cognitive and emotional dysfunctions following cranial irradiation. Here, our research further investigated the potential protective effects and mechanisms of LW-AFC on cranial irradiation–induced cognitive and emotional dysfunctions in mice.Methods: LW-AFC (1.6 g/kg) was intragastrically administered to mice for 14 days before cranial irradiation (7 Gy γ-ray). AHN was examined by quantifying the number of proliferative neural stem cells and immature neurons in the dorsal and ventral hippocampus. The contextual fear conditioning test, open field test, and tail suspension test were used to assess cognitive and emotional functions in mice. To detect the change of the neurogenic microenvironment, colorimetry and multiplex bead analysis were performed to measure the level of oxidative stress, neurotrophic and growth factors, and inflammation in the hippocampus.Results: LW-AFC exerted beneficial effects on the contextual fear memory, anxiety behaviour, and depression behaviour in irradiated mice. Moreover, LW-AFC increased the number of proliferative neural stem cells and immature neurons in the dorsal hippocampus, displaying a regional specificity of neurogenic response. For the neurogenic microenvironment, LW-AFC significantly increased the contents of superoxide dismutase, glutathione peroxidase, glutathione, and catalase and decreased the content of malondialdehyde in the hippocampus of irradiated mice, accompanied by the increase in brain-derived neurotrophic factor, insulin-like growth factor-1, and interleukin-4 content. Together, LW-AFC improved cognitive and emotional dysfunctions, promoted AHN preferentially in the dorsal hippocampus, and ameliorated disturbance in the neurogenic microenvironment in irradiated mice.Conclusion: LW-AFC ameliorates cranial irradiation–induced cognitive and emotional dysfunctions, and the underlying mechanisms are mediated by promoting AHN in the dorsal hippocampus and improving the neurogenic microenvironment. LW-AFC might be a promising therapeutic agent to treat cognitive and emotional dysfunctions in patients receiving cranial radiotherapy.
Optimal Dose of Serotonin Reuptake Inhibitors for Obsessive-Compulsive Disorder in Adults: A Systematic Review and Dose–Response Meta-Analysis
Authors: Xu Jiao , Hao Qinjian , Qian Ruiyi , Mu Xingyu , Dai Minhan , Wu Yulu , Tang Yiguo , Xie Min , Wang Qiang 
Published: September 2021

Background: Obsessive-compulsive disorder (OCD) is a common chronic mental disorder with a high disability rate. Serotonin reuptake inhibitors (SRIs), including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants, such as clomipramine, are the most common choices for the pharmacological treatment of OCD. Optimizing their use is pivotal in guiding clinical practice of OCD. However, there are few studies on the optimal dose of SRIs and there is controversy about their dose–response relationship and optimal target dose. Therefore, the objective of this study was to summarize the relationship between the dose and effect of SRIs, as well as the optimal dose of SRIs for OCD, as to propose future research directions.Methods: Medline, Embase, Biosis, PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and CINAHL were searched for relevant publications, and the search was up to February 22, 2020. We used a one-stage, robust error meta-regression (REMR) model to deal with the correlated dose–response data for SRIs from different studies. Doses of SRIs were converted to fluoxetine equivalents when performing dose–response analysis. Review Manager Program Version 5.3 and STATA software package (version 15.1) were applied to analyze data. The study protocol was registered with PROSPERO (number CRD42020168344).Results: Eleven studies involving 2,322 participants were included in final analysis. For SRIs, the dose–efficacy curve showed a gradual increase trend in the 0–40-mg dose range and then had a decreased trend in doses up to 100 mg fluoxetine equivalent. Dropouts due to adverse effects gradually increased throughout the inspected dose slope. The curve of dose of all-cause dropouts suggested no relationship between them. Sensitivity analysis proved that these results were robust.Conclusion: The systematic review found that the optimal dose for efficacy was about 40mg fluoxetine equivalent. Tolerability decreased with increased doses, and there was no significant correlation between acceptability and doses of SRIs. Therefore, the optimal dose of SRIs needs to consider effectiveness and tolerability.Systematic Review Registration: [PROSPERO], identifier [CRD42020168344].
Time-Specific Associations of Tumor Necrosis Factor-α Levels and Polymorphisms (−850 C/T or −308 G/A) With Suicidal Ideation in Acute Coronary Syndrome Patients
Authors: Kang Hee-Ju , Kim Ju-Wan , Lee Ju-Yeon , Kim Sung-Wan , Shin Il-Seon , Hong Young Joon , Ahn Youngkeun , Jeong Myung-Ho , Kim Jae-Min 
Published: September 2021

Background: Considering the association of inflammation with suicide and acute coronary syndrome (ACS), we investigated the individual and interactive effects of serum tumor necrosis factor-alpha (sTNFα) levels and two polymorphisms (−850 C/T and −308 G/A) on suicidal ideation (SI) after ACS.Methods: The SI status using items on the Montgomery–Åsberg Depression Rating Scale (MADRS), related covariates including sociodemographic and clinical characteristics, sTNFα levels, and tumor necrosis factor-alpha (TNF-α) polymorphisms were evaluated in 969 patients within 2 weeks after ACS. Of the patients, 711 were evaluated 1 year later for SI. Multivariate logistic regression models were used to calculate individual and interactive associations after adjusting for the covariates.Results: Higher (vs. lower) sTNFα levels and the −850 C/T or T/T (vs. C/C) polymorphism were significantly associated with SI 2 weeks after ACS, while only higher sTNFα levels were significantly associated with SI after 1 year. Significant interactive effects were detected between sTNFα (higher) levels and the −850 C/T (C/C or C/T) polymorphism on SI 2 weeks after ACS and between the two (−850 CC or CT and −308 G/A or AA) polymorphisms on SI 1 year after ACS.Conclusions: The sTNFα level and two polymorphisms (−850C/T and −308 G/A), separately or in combination, could be time-specific biomarkers for SI in ACS. Focused interventions for ACS patients at risk of SI might reduce the suicidal burden in patients with ACS.
COVID-19 Vaccine Perceptions and Differences by Sex, Age, and Education in 1,367 Community Adults in Ontario
Authors: Syan Sabrina K. , Gohari Mahmood R. , Levitt Emily E. , Belisario Kyla , Gillard Jessica , DeJesus Jane , MacKillop James 
Published: September 2021

Background: COVID-19 is a global pandemic and vaccination efforts may be impeded by vaccine hesitancy. The present study examined willingness to receive a COVID-19 vaccine, the associated reasons for willingness/unwillingness, and vaccine safety perceptions in a cross-sectional assessment of community adults in Ontario.Methods: One thousand three hundred sixty seven individuals (60.6% female, mean age = 37.5%) participated in this study between January 15, 2021 and February 15, 2021. Perceptions of vaccine safety and reasons for willingness/unwillingness to receive the COVID-19 vaccine were investigated using an online assessment. Perceptions were investigated in general and by age, sex and education using analysis of variance.Results: Overall, 82.8% of the sample reported they were willing to receive a COVID-19 vaccine and 17.2% reported they were unwilling. The three most common reasons for unwillingness were long-term side effects (65.5%), immediate side effects (60.5%), and lack of trust in the vaccine (55.2%). Vaccine willingness significantly differed by sex and education level, with female participants and those with less than a bachelor's degree being more likely to report unwillingness. Perception of COVID-19 vaccine safety was significantly lower (−10.3%) than vaccines in general and differed by age, sex and education, with females, older adults, and individuals with less than a bachelor's degree reporting lower perceived COVID-19 vaccine safety.Conclusion: In this sample of community adults, the COVID-19 vaccine hesitancy rate was less than one in five individuals, but with higher rates in population subgroups. Targeting public health messaging to females and individuals with less than bachelor's degree, and addressing concerns about long-term and immediate side effects may increase vaccine uptake.
Ferroelectric Properties and Spectroscopic Characterization of Pb(Mg1/3Nb2/3)O3-32PbTiO3:Er3+/Sc3+ Crystal
Authors: Zhang Jin , Xi Zengzhe , Wang Xinzhe , Feng Hao , Long Wei , He Aiguo 
Published: September 2021

An Er3+/Sc3+ co-doped 0.68Pb(Mg1/3Nb2/3)O3-0.32PbTiO3 ferroelectric single crystal was grown by high-temperature flux method. The remnant polarization Pr is 27.97 µC/cm2 and the coercive field Ec is 8.26 kV/cm for [100] oriented crystal. Green (524 and 551 nm) and red (654 nm) emission bands are generated at the 980 nm excitation, which corresponds to the 2H11/2→ 4I15/2, 4S3/2→ 4I15/2 and 4F9/2→ 4I15/2 transitions of Er3+, respectively. Judd–Ofelt theory has been applied to predict the spectroscopic characteristics of the as-grown crystals. The obtained J–O intensity parameters Ωt (t = 2, 4 and 6) are Ω2 = 0.76 × 10−20 cm2, Ω4 = 1.0 × 10−20 cm2, Ω6 = 0.55 × 10−20 cm2. Spectroscopic characteristics, including optical transition probabilities, branching ratio, and radiative lifetime of Er3+ in the crystal, are determined. The calculated radiative lifetimes of 4I13/2 and 4I11/2 energy levels are 2.82 ms and 2.61 ms, respectively. These investigations provide possibilities for the crystal Pb(Mg1/3Nb2/3)O3-0.32PbTiO3:Er3+/Sc3+ to be a new type of multifunctional crystal integrating electricity-luminescence.
Câncer infantojuvenil: caracterização a partir da Classificação Internacional da Atenção Primária
Authors: Barros Mariana Boulitreau Siqueira Campos , Lima Thaís Maria Ribeiro , Silva Isabelle Maria Freitas , Santana Jocrasta Bispo , Morais Vera Lúcia Lins de , Bushatsky Magaly 
Published: September 2021

Objetivo: caracterizar o câncer infantojuvenil conforme a Classificação Internacional da Atenção Primária (CIAP-2) em uma unidade de referência em Recife-PE. Método: trata-se de um estudo transversal de abordagem quantitativa, com entrevistas realizadas com os pais/responsáveis pelos pacientes em 2015. A sintomatologia relatada foi classificada conforme a CIAP em sua segunda versão, sendo os dados analisados em medidas absolutas e relativas. Tem aprovação pelo Comitê de Ética em Pesquisa, CAAE 42167315.4.0000.5208. Resultados: predominância do sexo masculino, entre 15-21 anos, com diagnósticos de leucemia, tumores ósseos, linfomas, respectivamente. Conforme a CIAP-2, os sinais/sintomas mais citados foram os inespecíficos. Conclusão: por esta inespecificidade, urge a necessidade de alertar e capacitar os profissionais na suspeição precoce dos sinais e sintomas do câncer infantojuvenil, subsidiando assim um melhor prognóstico.
Descritores: neoplasias; saúde da criança; saúde do adolescente.
The First Response of Family to Patient with Heart Attack in Banjarese Community South Kalimantan: A Phenomenological Study
Authors: Mohtar M. Sobirin , Hamzah  , Budiyarti Yuliani , Solikin  
Published: September 2021

Family first response in patients with heart attacks is very important in increasing patient safety. Friedman's familiy theory views that the family has a major role and function indecide the prompt and appropriate course of action. Orem's Wholly Compensatory System Theory looked at that familymust provide partial assistance when a family member is sick. Theory Cultural care Leininger looked at that family tend to maintain their culture when doing help. Indonesia, especially in Banjarmasin, has different social and cultural conditions so that the experience of making its first response will of course also be different. This study aims to explore the family experience of the first response to patients with heart attacks. This study used a qualitative method with a phenomenological study approach to 8 participants from Banjar community in South Kalimantan with purposive sampling technique. Collecting data using in-depth interviews with a tape recorder and field notes. The method of analysis uses Creswell. There are 6 themes found namely (1) The initial understanding of a family about heart attack is in the form of menyamak or angin duduk, (2) The family's first action in a patient with an attackheart in the form of cabut angin, (3) family onset in doing his first response against attacks in the form of estimated time (4) Family delay factors in doing the first response in the form of a cause(5) The emotional response of the family in facing a heart attack such as neutral response, anxiety and shock. (6) Meaning as a helper for family members such as pride, relief and pleasure. Nurses need to rectify the culture that is in conflict with health by changing the family mindset of their understanding of diseases, especially heart attacks.
The Belgica 121 expedition to the Western Antarctic Peninsula: a detailed biodiversity census
Authors: Danis Bruno , Christiansen Henrik , Guillaumot Charlène , Heindler Franz , Jossart Quentin , Moreau Camille , Pasotti Francesca , Robert Henri , Wallis Ben , Saucède Thomas 
Published: September 2021

This dataset relates to the biodiversity census carried out during the Belgica 121 (B121) expedition to the Western Antarctic Peninsula from February to March 2019. One of the aims of the campaign was to explore the surroundings of the Gerlache Strait and to carry out a detailed biodiversity census focusing on inter- and subtidal shallow-water areas using both classic descriptive marine ecology methods, as well as state-of-the art techniques (habitat mapping, genetics, trophic ecology). The biodiversity census was carried out onboard a nimble research vessel, RV Australis. This dataset will offer access to the raw data on biodiversity occurrences, obtained using a range of methods described in this data paper.
New raw biodiversity data for a poorly-sampled region (Western Antarctic Peninsula) with a special focus on shallow ecosystems.
Simulating operation of power units 1 and 2 at Novovoronezh NPP II with two electrical feed pumps disabled and the backup pump not enabled
Authors: Gusev Igor N. , Vorobyev Aleksandr P. , Kozlovsky Mikhail N. , Padun Sergey P. 
Published: September 2021

Introduction. The article analyzes the operation of Unit 1 and 2 of Novovoronezh Nuclear Power Plant II (equipped with VVER-1200 reactors) with two electrical feed pumps disabled and the backup pump not enabled. These operating conditions are subsequently simulated using the power unit model software-hardware package (PUM SHC) developed by LLC IF SNIIP ATOM.
Research objectives. The objective of this work was to check the reliability of the forecasts of changes in the power unit parameters obtained using the PUM SHC, based on operational data.
Methods. The simulated power unit parameter changes in transient conditions were in good agreement with the data collected in real tests. During the simulation, the power unit dynamic stability was preserved, i.e., the operational parameters were within the design limits and did not exceed the protection operation set points.
Results. The results of the work suggest the possibility of using current NPP power unit simulations:
for developing proposals for adjusting the operation control algorithms in case of malfunctions and emergency modes with the main equipment shutdown and power unit protection actuation; and
for verifying design solutions for updating the power unit systems, which are associated with the use of new equipment or changes in flow diagrams.
Conclusion. Current power unit models can be applied both for existing power units and for new ones that are being commissioned.
EFFECTIVE WAREHOUSE MANAGEMENT USING LEAN CONCEPTS AND ITS EFFECTS ON PAKISTAN’S FMCG INDUSTRY
Authors: MUHAMMAD RAFAY SHAIKH  , DR. MUHAMMAD ASIM  , SALMAN MANZOOR  
Published: September 2021

Warehousing plays an important role in integrating the supply chain of the industry. But given the volatility and dynamic nature of supply chain management as a field, the factors that need to be considered when implementing lean in the warehousing that not every warehouse structure is the same. While implementing other external factors and the concerns of the people working the warehousing needs to be considered. Because the purpose is the same that effective and efficient warehouse, with less cost and more profit. In addition to this, the study will describe and the theory of core competencies on parallel practices and how these competencies are used in implementing the lean methodology in the warehouse. A survey was carried out through questionnaires to determine which competencies are best suited to choosing a lean in the warehouse. Hypothetically, the findings showed that in making warehouse effective all three independent factors have their own significance over the provided two dependent factors. Concluding, the study will act as a touchstone in understanding the lean management practices on shorter yet connected enterprises in small to large scale industries.
Music Fundamentals for Musical Theatre
Authors: Riley Christine 
Published: September 2021

Musical theatre students and performers are frequently asked to learn musical material in a short space of time; sight-read pieces in auditions; collaborate with accompanists; and communicate musically with peers, directors, music directors and choreographers. Many of these students and performers will have had no formal musical training.
This book offers a series of lessons in music fundamentals, including theory, sight-singing and aural tests, giving readers the necessary skills to navigate music and all that is demanded of them, without having had a formal music training. It focuses on the skills required of the musical theatre performer and draws on musical theatre repertoire in order to connect theory with practice.
Throughout the book, each musical concept is laid out clearly and simply with helpful hints and reminders. The author takes the reader back to basics to ensure full understanding of each area. As the concepts begin to build on one another, the format and process is kept the same so that readers can see how different aspects interrelate.
Through introducing theoretical ideas and putting each systematically into practice with sight-singing and ear-training, the students gain a much deeper and more integrated understanding of the material, and are able to retain it, using it in voice lessons, performance classes and their professional lives.
The book is published alongside a companion website, which offers supporting material for the aural skills component and gives readers the opportunity to drill listening exercises individually and at their own pace.
Music Fundamentals for Musical Theatre allows aspirational performers – and even those who aren’t enrolled on a course – to access the key components of music training that will be essential to their careers.
Introducing Aesthetics and the Philosophy of Art
Authors: Hudson Hick Darren 
Published: September 2021

‘Place in garden, lawn, to beautify landscape.’
When Don Featherstone’s plastic pink flamingos were first advertised in the 1957 Sears catalogue, these were the instructions. The flamingos are placed on the cover of this book for another reason: to start us asking questions. That’s where philosophy always begins.
Introducing Aesthetics and the Philosophy of Art is written to introduce students to a broad array of questions that have occupied philosophers since antiquity, and which continue to bother us today—questions like:
– Is there something special about something’s being art? Can a mass-produced plastic bird have that special something?
– If someone likes plastic pink flamingos, does that mean they have bad taste? Is bad taste a bad thing?
– Do Featherstone’s pink flamingos mean anything? If so, does that depend on what Featherstone meant in designing them?
Grounded in an array of real-world examples, from the classical to the contemporary—and from Marcel Duchamp’s signed urinal to The Exorcist to the ugliest animal in the world—each chapter in this text opens with an illustrated guiding case, introducing a number of the issues to be discussed, and serving as a touchstone thoughout the chapter.
With its trademark conversational style, clear explanations, and wealth of supporting features, Introducing Aesthetics and the Philosophy of Art is the ideal introduction to the major problems, issues, and debates in the field. Now expanded and revised for its second edition, Introducing Aesthetics and the Philosophy of Art is designed to give readers the background and the tools necessary to begin asking and answering the most intriguing questions about art and beauty, even when those questions are about pink plastic flamingos.