bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-219-5p is Involved in the Proliferation, Migration and Invasion of Oral Cancer Through SOX5 Regulation
Authors: Zhou Ting , He Ying , Dong Xiao-Han , Chen Bo , Ton Jun , Xiyang Yan-Bin , Mao Rui 
Published: June 2021

Abstract
Purpose Oral cancer has the characteristics of rapid progression, wide invasion and poor prognosis, which induces higher mortality in the patients. At present, there are about 300 thousand new cases of oral cell carcinoma worldwide. Particularly, the incidence rate of oral cancer in China is relatively high. Therefore, it urgently needs to understand the pathogenesis of oral cancer and molecular mechanisms underlying. Abnormal regulation of miR-219-5p is present in various types of cancer. However, the relationship between miR-219-5p and its targets in oral cancer has not been well evaluated. Methods Western blotting and Quantitative RT-PCR were used to detect the expression of SOX5 in oral cancer tissues.Migration ,cell proliferation,and invasion were detected using CCK8 assay,Conlony formation assay and Transwell assays .The interaction between SOX5 and miR-219-5p and oral cancer was confirmed using dual-luciferase reporter assays.Result This study aims to investigate the possible roles of miR-219-5p and its potential target gene, SOX5, in the progress of oral cancer. Our data showed that the high miR-219-5p and low SOX5 expression levels were associated with improved survival rates in patients. miR-219-5p level was negatively correlated with the expression of SOX5. Genetic analysis and luciferase assay revealed that the miR-291-5p regulated SOX5 expression by targeting the 3'-UTR region of SOX5 mRNA. Functionally, we confirmed that miR-219-5p mimics inhibited SOX5 expression and suppressed the proliferation, colony formation ability, invasion and migration of oral cancer cells, SCC4 and SCC9. In contrast, inhibition of miR-219-5p increased SOX5 levels and promoted the vitality and mobility of oral cancer cells. Furthermore, special siRNA targeting SOX5 partially neutralized the effects of miR-219-5p inhibitor. Conclusions This study demonstrates that miR-219-5p may inhibit the proliferation, migration and invasion of oral cancer by targeting the expression of SOX5, which provided novel candidates for clinic prognosis and/or therapy.
Association of significantly elevated serum levels of NGAL and IGFBP4 in patients with diabetic nephropathy
Authors: Ali Hamad , Abu-Farha Mohamed , Alshawaf Eman , Devarajan Sriraman , Bahbahani Yousif , Al-Khairi Irina , Cherian Preethi , Alsairafi Zahra , Vijayan Vidya , Al-Mulla Hamad , Attar Abdulnabi Al , Abubaker Jehad 
Published: June 2021

Abstract
Background: Diabetic nephropathy (DN) is a kidney-related complication affecting approximately 40% of patients with diabetes. Current DN diagnostic criteria predominantly rely on albuminuria and serum creatinine levels; however, the specificity and reliability of both markers are limited. Hence, reliable biomarkers are required to diagnose and effectively manage DN progression. Methods: Here we investigated the expression level and the association between neutrophil gelatinase-associated lipocalin (NGAL), IGFBP-1, IGFBP-3, and IGFBP-4 in patients with DN and compared it to patients with T2D and control participants. A cohort comprise of 159 individuals (DN = 67) was clinically evaluated and circulatory levels of NGAL, IGFBP1, IGFBP3, and IGFBP4 were determined using ELISA. Results: Levels of circulating NGAL were significantly higher in people with DN compared to people with T2D and non-diabetic groups (92.76 ± 7.5, 57.22 ± 8.7, and 52.47 ± 2.9 mg/L, respectively; p < 0.0001). IGFBP4 showed a similar pattern, where it was highest in people with DN (795.61 ng/ml ±130.7) compared to people with T2D and non-diabetic respectively (374.56 ng/ml ±86.8, 273.06 ng/ml ±27.8, ANOVA p<0.01). Our analysis presents a significant positive correlation between NGAL and IGFBP4 in people with DN (ρ =.620, p <0.005). IGFBP4 also correlated positively with creatinine level and negatively with eGFR, in people with DN supporting its involvement in DN. Conclusion: Our results report the association between the rise in NGAL and IGFBP4 levels in DN and suggest them as potential markers to aid DN diagnosis.
Active Fault Tolerant Nonsingular Terminal Sliding Mode Control for Electromechanical System Based on Support Vector Machine
Authors: Hu Jian , Yang ZhengYin , Yao JianYong 
Published: June 2021

Abstract
At present, electromechanical actuator is very popular in the industrial field because of environmental protection, energy saving and high efficiency. At the same time, it also puts forward higher requirements for its reliability. In this paper, a fault tolerant nonsingular terminal sliding mode control method for electromechanical system based on support vector machine (SVM) is proposed. SVM is designed to estimate the possible faults in the system by off-line learning from large sample data with gradient descent method. The estimation is used to compensate the possible fault with feedforward cancellation technique in the proposed controller. An observer is designed to estimate the system states to make fault detection and reconstruct the controller when something is wrong in electromechanical system. A nonsingular terminal sliding mode surface is designed, and Lyapunov theorem is used to derive a parameter adaptation law for handling the parametric uncertainty and a nonsingular terminal sliding mode control law. It is guaranteed the proposed controller can achieve bounded stability. Extensive comparative simulation and experimental results illustrate the effectiveness and advancement of the proposed controller compared with several other main-stream controllers.
Modeling the longitudinal outcomes of congestive heart failure patients: A case study at Wachemo University Nigist Eleni Mohammed Memorial Referral Hospital
Authors: Sultan Mohammed , Ahmed Ritbano 
Published: June 2021

Abstract
The linear mixed model is one of the common models used to analyze the longitudinal data;it may comprise of separate (Univariate), joint Bivariate, and joint Multivariate linear mixed model, which is predicted on the number of response variables incorporated in the analysis. Adjusting for correlation matrix and covariance matrix between and within subjects is one reason why modern longitudinal data analysis techniques are deemed more appropriate than some of the previous methods of analysis. Some studies assume that the correlation between observation is zero. However, it is unlikely that repeated measurements on the same individual Will actually be independent. To that end, comparing the different linear mixed models identifying the appropriate model demonstrates that the evolution of patients with congestive heart failure is necessary.In this study the separate, bivariate, and multivariate linear mixed models were compared with different covariance and correlation structures. Finally, a multivariate linear mixed model with autoregressive order one correlation structure and unstructured covariance structure for random effects, to consider within and between patient's variations, was considered as a best model to depict the evolution of patients with congestive heart failure.
A Review of Trends and Crime Patterns of Arson Offences in India: 2009-2018
Authors: Savia Fernandes Glorita , Mulimani C. F. 
Published: June 2021

Abstract
Crime statistics provide innate knowledge on different types of crimes, their jurisdictions, current status and future predictive trends in society. This research paper is based on the review of data available in the national open access publication of crime data in the country. It focuses on arson offences in India for the last decade from 2009 to 2018. It is important to study national crime statistics to enhance policing and criminological studies in different trends encountered through research. Explaining the trends of a crime in a country can help in establishing better policies, reporting systems, investigative methods and ultimately, a better criminal justice system. While Criminology studies have been generally focused on behavior, causes, etc. associated with violent crimes like offences against the body, violence against women, offences against children; this paper is aimed at discussing trends with respect to arson, a lesser known offence in our country.
Propuesta conceptual para la mitigación de riesgo por inundación en la unidad de planeamiento zonal (UPZ) Tibabuyes, localidad de Suba
Authors: Sierra Florez Didier camilo , Valbuena Villamil Tatiana , Ayala Rodriguéz Angie , Gómez Rodriguez Luz Adriana 
Published: June 2021

Contextualización: la localidad de Suba, específicamente la Unidad de Planeamiento Zonal (UPZ) Tibabuyes, corresponde a un sector de la ciudad de Bogotá que, debido a su proceso de expansión desequilibrado, ha llevado a que las personas se asienten de manera ilegal sobre las Áreas Protegidas como el Humedal Juan Amarillo, el Humedal de la Conejera y la Zona de Manejo Especial del río Bogotá pertenecientes a la Estructura Ecológica Principal y se encuentren expuestos a fenómenos naturales como la inundación.

Vacío de conocimiento: Las incertidumbres en la variabilidad climática en zonas de vulnerabilidad hacen que la población sea propensa a sufrir accidentes de acuerdo a los posibles eventos naturales por una inadecuada planeación zonal y sobre todo una falta de planeación, es por esto que la investigación busca brindar diferentes herramienta metodológicas conceptuales para mejorar las condiciones que puedan llegar a afectar la calidad de vida de los habitantes y que puede llegar a generar consecuencias de ocupación de suelos importantes para el país y a aumentar significativamente el riesgo.

Propósito: diseñar una propuesta conceptual para reducir el riesgo de inundación en UPZ Tibabuyes.
Metodología: se usó un enfoque en la Acción Participativa (IAP) dentro de la cual se establecieron tres fases de investigación en donde se realizaron los análisis de percepción en la zona de acuerdo a las necesidades establecidas por la ronda hídrica, en la cual se pudo categorizar la amenaza según los escenarios de inundación; para esto, se determinaron los parámetros de evaluación (alta, cuando la lámina de agua es >1,0 m y su velocidad > 2,0 m/s) y la categoría (media, cuando la lámina de agua es >0,5 < 1,0 m y su velocidad está entre 1,5 a 2,0 m/s).

Resultados y conclusiones: se determinó el plan de acción que consta de 17 estrategias, de las cuales 10 corresponden a estrategias implementadas es caso de presentarse un escenario de riesgo alto de inundación, y las 7 estrategias complementarias deben ser empleadas en caso de presentarse un escenario de riesgo medio de inundación. en ambas se relaciona la población afectada, los requerimientos y actividades técnicas por desarrollar junto con un presupuesto estimado y sus posibles fuentes de financiación.
Suelo mineral como componente de sustrato para plantas
Authors: Demari Avrella Eduarda , Pinto Paim Luciana , Tedesco Marília , Armiliato Emer Aquélis , Schafer Gilmar , Dutra de Souza Paulo Vitor , Fior Claudimar Sidnei 
Published: June 2021

Contextualización: Sustrato es todo el material poroso, que, asociado a una maceta, proporciona ancoraje y suficientes niveles de agua y oxígeno al desarrollo de las plantas.
Vacío de conocimiento: Algunos materiales cuando adjuntados a la formulación suelen generar alteraciones en el producto final, las cuales pueden ser desventajosas, dependientes de su aplicación.
Propósito del estudio: Evaluar la influencia del suelo mineral bajo sus características química y física, cuando utilizado cómo componente de sustrato para plantas.
Metodología: Se empleó un argisol rojo distrófico típico, que se autoclavó, tamizó (malla 4,75 mm) y posteriormente se mezcló bajo diferentes proporciones (0, 25, 50, 75 e 100%) con turba de Sphagnum o polvo-de-coco (v/v). Las mezclas se sometieron a la caracterización física, química y biológica. Se empleó el diseño estadístico enteramente casualizado, con tres repeticiones por tratamiento. Los datos se sometieron al análisis de varianza y regresión polinomial (P < 0,05).
Resultados y conclusiones: Al añadirse suelo en la formulación de los sustratos hubo disminución en la conductividad eléctrica y manutención del pH, además del aumento expresivo en las densidades húmeda y seca, y reducción en la porosidad total, espacio de aireación, disponibilidad y capacidad de retención de agua. Además, se encontraron hongos y nematodos en el suelo, que puede ser un inoculador de patógenos. Por lo tanto, el empleo de suelo mineral cómo componente de sustrato, además de generar formulaciones con características de cultivo inadecuadas, pudiendo influenciar negativamente el crecimiento y desarrollo vegetal, provoca daños ambientales debido a su extracción, conllevando a una producción insostenible a largo plazo.
Frequency Occurrence and Percentage Distribution of Rh C, Rh c, Rh E and Rh e Blood Group Amongst Pregnant Women Attending Antenatal Clinic in Port Harcourt, Nigeria
Authors: Christian Serekara Gideon , Eze Evelyn Mgbeoma , Badom Barizoge Monsi , Pepple Ibiere Allwell , Simeon Christopher Aloy 
Published: June 2021

Background: The Rhesus (Rh) blood group is one of the most complex blood groups in humans comprising mainly of Rh D, C, c, E and e. However, only Rh D is routinely screened for in Nigeria despite the fact that other Rh antigens are clinically significant and can cause haemolytic disease of the newborn and delayed haemolytic transfusion reactions.
Aim: The aim was to determine the frequency distribution of Rh C, c, E and e blood groups among pregnant women attending antenatal clinic in Port Harcourt, Nigeria.
Study Design: The study consisted of 147 apparently healthy pregnant women within the age range of 18-45 years, attending a selected Primary Healthcare Centre (Obio Cottage Hospital) in Port Harcourt. The study was carried out from January 20, 2020 to March 27, 2020. The presence of Rh C, c, E and e blood groups were investigated using Anti-C, c, E and e monoclonal antibody in the same order.
Results: Rh C, c, E and e were observed in 38.09%, 100%, 17.68% and 100% in the same order.
Conclusion: The study indicated dominance of Rh c and Rh e over Rh C and Rh E among the studied pregnant women. It is necessary to take into cognizance the fact that the presence of Rh C, c, E and e antigens may be the cause of some delayed transfusion reactions and haemolytic disease of the foetus and newborn. Therefore, routine antigen typing for Rh antigens may help in decreasing red blood cell allo-immunization and delayed haemolytic transfusion reaction during pregnancy.
Multiple anthelmintic resistance at a goat farm in Slovakia
Authors: Babják M. , Königová A. , Várady M. 
Published: June 2021

SummaryCases of parasite resistance to the main classes of anthelmintics are increasingly reported from small ruminants at farms in Europe. We visited a goat farm in Slovakia in November 2019 with suspected parasite problems that reduced productivity and performed anin vivofaecal egg count reduction test (FECRT) and anin vitrolarval development test (LDT) for all three main classes of anthelmintics. The lowest efficacy (60 %) detected by FECRT was for ivermectin (IVM). Benzimidazole (BZ) efficacy ranged between 80.3 and 86.5 %, and levamisole (LEV) efficacy was 94 %. The results from thein vivoFECRT test were confirmed by thein vitroLDT. Minimum inhibitory concentration (MIC) 173.6 ng/ml for IVM several times exceeded the recommended threshold of 21.6 ng/ml. Mean LD50for BZ was equal to the threshold concentration, but the other threshold criteria indicated a low level of resistance in the population. The LDT did not indicate the presence of resistance only for LEV. The MIC 1.0 μg/ml for LEV was evaluated as susceptible with respect to species composition.Teladorsagiawas the dominant genus after treatment with BZ, IVM, and LEV.Haemonchus contortuswas identifi ed after treatment with BZ and LEV.
Foodborne Parasitic Diseases in the Neotropics – a review
Authors: Chávez-Ruvalcaba F. , Chávez-Ruvalcaba M. I. , Moran Santibañez K. , Muñoz-Carrillo J. L. , León Coria A. , Reyna Martínez R. 
Published: June 2021

Summary
Within the Universal Declaration of Human Rights, it is stated that everyone has the right to an adequate standard of living, which ensures, as well as their family, health and well-being, and food, thereby ensuring adequate nutrition. One of the major threats to overcome this is to ensure food security, which becomes particularly challenging in developing countries due to the high incidence of parasitic diseases. The World Health Organization (WHO), considers it one of the main causes of morbidity, closely linked to poverty and related to inadequate personal hygiene, consumption of raw food, lack of sanitary services, limited access to drinking water and fecal contamination in the environment. It is estimated that more than a fifth of the world’s population is infected by one or several intestinal parasites, and that in many countries of Central and South America the average percentage of infected people is 45%, being Taenia solium, Echinococcus granulosus, Toxoplasma gondii, Cryptosporidium spp, Entamoeba histolytica, Trichinella spiralis, Ascaris spp, Trypanosoma cruzi and Fasciola hepatica some of the most important ones in the neotropics. One of the main reasons why these diseases are diffi cult to control is t he ignorance of their lifecycles, as well as symptoms and current epidemiology of the disease, which contributes to a late or erroneous diagnosis. The present work aims to discuss and make public the current knowledge as well as the general characteristics of these diseases to the general audience.
Stock mapping, size structure and biological parameters of the clam Polititapes aureus in the shellfish production area of the southern Tunisian waters (Central Mediterranean)
Authors: Derbali Abdelkarim , Jarboui Othman 
Published: June 2021

Abstract
The clam Polititapes aureus is one of the most abundant shellfish species in the southern Tunisian waters. Its current exploitation status and management are becoming a major concern for fishing industry in Tunisia. The significant ecological role of the species and possible future commercial benefits require a better knowledge of its stock. This research is the first attempt to investigate its current status in an area with the largest shellfish production. The obtained results showed a scattered distribution. The stock density ranged from 0 to 124 ind. m−2, and biomass values varied from 0 to 300 g m−2. This results in a remarkable biomass of 201.2 (± 64.6) t and high abundance reaching 91.3 ± 32.9 million individuals, estimated an area of 4182 ha. The species distribution was also investigated, with the size ranging from 4.9 to 35.34 mm. The overall sex ratio (F:M) was 1.26:1, which significantly deviated different from parity (1:1). The main environmental factors were identified and several abiotic parameters were found to strongly affect the spread of the clam species. The clam reproduce well and is expected to almost meet the domestic market demand through artisanal fishery.
Hubungan Antara Kecerdasan Adversitas dan Motivasi Berprestasi dengan Kecemasan Berbahasa Asing pada Mahasiswa Tingkat Akhir Program Sarjana Universitas Sebelas Maret
Authors: Cesarini Dwike Aprilia 
Published: June 2021

Kesiapan lulusan mahasiswa UNS perlu dipersiapkan sebelum memasuki dunia kerja yang menantang, salah satunya dengan pencapaian kompetensi dalam berbahasa Inggris. Berdasarkan hasil capaian tes (English for Academic Purposes) pada tahun 2018 mahasiswa UNS secara keseluruhan memiliki rata-rata indeks pencapaian C yang tergolong rendah. Pencapaian tes prestasi yang tergolong rendah tersebut dapat dipengaruhi oleh kecemasan berbahasa asing yang dialami oleh mahasiswa. Kecemasan berbahasa asing merupakan perasaan takut, khawatir, serta kepercayaan irasional yang mampu menghambat atau mengganggu performansi ketika belajar maupun berkomunikasi bahasa asing. Faktor yang dapat mempengaruhi kecemasan berbahasa asing individu adalah tingkat kecerdasan adversitas dan motivasi berprestasi dari individu. Penelitian ini bertujuan untuk mengetahui hubungan antara kecerdasan adversitas dan motivasi berprestasi dengan kecemasan berbahasa asing pada mahasiswa tingkat akhir program Sarjana di UNS. Penelitian ini menggunakan studi korelasi dengan sampel 367 mahasiswa tingkat akhir dari sebelas fakultas yang ada di UNS yang diambil menggunakan disproportional random sampling. Penelitian ini menggunakan Skala Kecemasan Berbahasa Asing (r=0.959) , Skala Kecerdasan Adversitas (r=0.945) dan Skala Motivasi Berprestasi (r= 0.882) . Hasil uji hipotesis menunjukkan nilai F hitung sebesar 13.538 (F tabel =3.02; Fhitung Ftabel) dan (p=0.000 0.05). Hal ini menunjukkan terdapat hubungan yang signifikan antara kecerdasan adversitas dan motivasi berprestasi dengan kecemasan berbahasa asing pada mahasiswa tingkat akhir. Nilai koefisien korelasi dalam penelitian ini adalah 0.069 yang menunjukkan bahwa kontribusi kecerdasan adversitas dan motivasi berprestasi dengan kecemasan berbahasa asing yaitu 6.9% dengan nilai sumbangan efektif dari kecerdasan adversitas sebesar 5.1% sedangkan motivasi berprestasi sebesar 1.8% dan sisanya dipengaruhi oleh variabel lain. Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan antara kecerdasan adversitas dan motivasi berprestasi dengan kecemasan berbahasa asing pada mahasiswa tingkat akhir program sarjana di Universitas Sebelas Maret. Kata kunci: Kecerdasan Adversitas, Kecemasan Berbahasa Asing, Motivasi Berprestasi
RETRACTED Defamation Strategy Implementation in the German Political Discourse
Authors: Kryachkova A. P. 
Published: June 2021

RETRACTEDThe main definitions of political discourse are introduced in this article. The author also suggests her own definition of this term. The participants of political discourse use various communicative strategies in order to influence opponents. The article reviews various definitions of communicative strategy term. The author gives her own definition of communicative strategy term and describes the main political discourse strategies. The purpose of the article is to review defamation strategy implementation and to identify its role in political discourse of Germany based on Bundestag's political wrangling. The author describes the main tactics and conversational turns of defamation strategy and its development in German politicians' speech image. Defamation strategy is one of the leading strategies in any aggressive verbal behavior discourse. The research describes main communicant's intentions by using of defamation strategy. The addresser uses this kind of strategy to offend the opponent's positive image aiming to undermine opponent's credibility and to reduce his significance at the political stage. There are following tactics of defamation strategy: offence, accusation, jeer. The article reviews the functioning of named tactics in political discourse of Germany. The article describes special aspects of above listed tactics, distinguishes terms of offence and accusation, gives examples from Bundestag's political speeches. Every tactic has its conversational turns, that are realized by various linguistic means. The article analyses political comments as an evaluative lexis subject. It also suggests analysis of such turns as intensification, comment's metaphoricity, comparative constractions, that promote better perlocutionary effect.