bluuebunny/crossref_metadata_2025_split huggingface dataset:
The problem of suicidal behavior in adolescence
Authors: Ivanov Roman , Ivanova Larisa , Maltseva Tatyana 
Published: September 2021

The article examines the problems of suicidal behavior in adolescents, as well as ways to prevent and counteract this destructive behavior. This is due today to the great urgency of this social problem, both for the Russian and for the world community. In the study, the tasks were set to study the characteristics of suicidal behavior in adolescents; the study of the social significance of adolescent suicide in the public consciousness in order to determine ways to solve the problem of suicidal behavior in adolescents to reduce suicidal moods among young people. Among the causes of suicidal behavior in adolescents, interpersonal and intrapersonal conflicts are considered, as well as economic and socio-political conditions. Particular attention is paid to measures to counteract suicidal behavior with the help of the adolescent's immediate environment: parents, teachers, other closest social agents by forming a social position on suicide in the latter (preventive work).
The purpose of this article is to study the problems of adolescent suicide, its social significance and to identify ways and mechanisms to reduce the risks of suicide among children and adolescents.
The subject of research in this article is suicidal behavior, its causes and characteristics of its appearance.
Intra-annual diameter growth variation of six common European tree species in pure and mixed stands
Authors: Strieder Emanuel , Vospernik Sonja 
Published: September 2021

Studies of intra-annual growth are particularly useful for understanding tree growth because of their high temporal resolution. This study was performed in Austria and included hourly band dendrometer data of 244 annual tree recordings from six tree species ( (L.) Karst., L., Mill., Mill., L., spp. ( (Matt.) Liebl., L.) sampled on five sites with contrasting site conditions in pure and mixed stands and on trees of different social position. Measurements encompassed 1â7 years. Cumulative diameter increment was modelled by logistic mixed-effects models with random effects at the tree and year level. The results showed large differences in seasonal growth patterns between sites, with a clearly shorter growing season at the drier sites. Species specific response on dry sites could be linked to drought characteristics, whereas response on more humid sites was related to light requirements or successional status. The deciduous trees showed earlier growth culmination and shorter growing periods than the evergreen species. Individual tree growth of spp., , and was positively affected by mixture whereas , and showed no or adverse mixture effects. Mixture effects differed between years and social position. Furthermore, increment culmination was earlier in mixed stands, but shifts were minor. Tree growth differed by social position with dominant trees showing the largest increment and the longest growth duration, with shifts in tree growth patterns due to social position being as large as those between different sites.Picea abiesPinus sylvestrisLarix deciduaAbies albaFagus sylvaticaQuercusQuercus petraeaQuercus roburQuercusP. abiesF. sylvaticaL. deciduaP. sylvestrisA. alba
Distance Learning Model Innovation for Early Childhood during COVID-19 Pandemic
Authors: Musyafa Ali  , Samiaji Mukhamad Hamid , Cesilia Prawening  
Published: September 2021

Purpose – The COVID-19 pandemic has changed many lives, especially in the field of education. These changes start from the level of early childhood education, elementary education, to higher education. The learning process initially done conventionally in early childhood education has now been transformed into distance-learning or online. This sudden transformation of learning is essential to present an innovative distance learning model in the early childhood education environment. This study describes the distance learning model innovation for early childhood, implemented by PAUD Wadas Kelir, South Purwokerto, during the COVID-19 pandemic. Teachers designed this learning model at PAUD Wadas Kelir by combining fun and unique online and offline learning.
Design/methods/approach – This type of research is field research with a descriptive qualitative method. In collecting data, researchers used three methods, i.e., observation, interviews, and documentation. The data analysis technique used, i.e., reducing data, presenting data, and drawing conclusions. Moreover, the validity of the data is tested using triangulation techniques.
Findings – The results of this study show that there are ten learning model innovations implemented by ECE Wadas Kelir, i.e., learning with parental involvement, work projects, study visits, quizzes, online learning, creativity competitions, films and videos, creative and interactive stories, recording materials, and learning appreciation.
Research implications/limitations – This case study focuses on Early Childhood Education (ECE) learning models applied to early childhood education institutions during the pandemic in PAUD Wadas Kelir, South Purwokerto, but it is unlikely that the situation is different elsewhere because the pandemic is Indonesia and global.
Practical implications – This case study demonstrated how the application learning models of ECE during the pandemic are effective for children's growth and development.
Originality/value – This paper contributes to knowledge and understanding of applying several learning models for ECE during the pandemic as reference material in implementing the learning process for early childhood.
Paper type Case study
Learning the Yellow Book in Al-Fitroh Jejeran Boarding School, Wonokromo Pleret Bantul: Study of Learning Materials in Philosophical Perspective
Authors: Mujahid Mujahid 
Published: September 2021

Many studies on boarding school have been carried out before by researchers. But most of these studies are more descriptive by describing what happened in the boarding. While studies about boarding school analyzed with philosophical theory are still rarely conducted. The subjects of this study were caregivers and some students who were selected purposively. The data collection uses observation, interview and documentation. This paper aims to reveal the philosophical perspective of the learning materials of the Yellow Book in al-Fitroh Jejeran Boarding school, Wonokromo Pleret Bantul. The philosophical framework used as a reference for the analysis of this study is the Religious-Conservative tradition (al-Diniy al-muhafidz). Religious -Rational (al-Dini al-' Aqliy) and Pragmatic-Instrumental (al-Darai'i) traditions. The results showed that philosophically learning the Yellow Book in that boarding school uses religious-conservative tradition (al-Diniy al-muhafidz). The source of the material taught refers to the yellow books produced by scholars in the Middle Ages. The reason Kyai refers in the classical books because the books were written by salafiyyin scholars closer to its existence with the Prophet, to allow the truth is more assured. According to his beliefs getting closer to the existence of the prophet, the value of truth is more authentic. While the Religious-Rational School (al-Dini al-'Aqliy) has not got an adequate place in the Boarding School. The existence of general science is not given to students so that the students are not affected by outside influences that will slowly erode and keep students away from religious sciences. While the instrumental pragmatic tradition (al-Darai'i) which is characterized by accommodating a variety of tangible sciences related to the direct needs of humans, both spiritual needs and material needs, must be recognized not all can be organized by the boarding school completely.
Correlation Between Total Cholesterol Level with Blood Pressure of Hypertensive Patients in Kalidoni, Palembang
Authors: Umar Tungki Pratama , Mariana Mariana 
Published: September 2021

Background: Hypertension is the main problem worldwide. It has strong relationship with other component of metabolic syndrome, namely dyslipidemi. Authors are analyzing the correlation between total cholesterol level and blood pressure in the hypertensive patient at Kalidoni Primary Health Center, Palembang, Indonesia.Methods: This was a cross-sectional study involving 82 adult hypertensive patients. Data were collected from the medical record of patients who are visiting Kalidoni Primary Health Center in December 2019-January 2020. Demographic data, blood pressure, and total cholesterol level were gained. Obtained data are analyzed descriptively (frequency distribution) and analytically (correlation using Pearson or Spearman method).Result: Significant positive correlations were observed between total cholesterol level and systolic blood pressure (r=0.509, p=0.000) in addition to body weight and diastolic blood pressure (r=0.279; p=0.011).Conclusion: Blood cholesterol level had a significant correlation with moderate strength for determining systolic blood pressure level in hypertensive patients.
Gambaran Profil dan Infeksi Cacing Usus pada Pekerja di Tiga Rumah Potong Hewan Provinsi Riau
Authors: Maryanti Esy , Zenia Yola , Aldi Afrinaldi , Mulia Fadly , Linda Mislindawati 
Published: September 2021

Background: Intestinal worm infestation is still a health problem in Indonesia that is often neglected. This disease is chronic in nature and is strongly influenced by factors of environmental hygiene and sanitation. Slaughterhouses are places where animals in the form of cows, goat/ sheep and pigs are slaughtered to be distributed to meat sellers or to reataurants. This study aims to determine the profil description and incidence of intestinal worm infestations in workers in three slaughterhouses in Riau Province.Methods: This study was a cross-sectional descriptive study in August – October 2020 in three slaughterhouses in Riau Province ( Pekanbaru, Duri and Dumai city). Stool examination was carried out using the Kato Katz Method at the Parasitology Laboratory Medical Faculty, Universitas Riau. Result: Do A total 37 workers who were examined found 35 men, age range 21 – 30 yo as much as 38% with latest education 46% was high school, length of work 1 – 5 years as much as 57% and as much as 41% have normal nutriotional status. Six workers found positive for intestinal worm infections (16%), there were three hookworm infections and one each to Trichuris trichiura, Oxyuris vermicularis and Hymenolepis diminuta.Conclusion : There were still intestinal worm infections among workers in the three slaughterhouses. Intestinal worm infection usually occurs in children and rarely occurs in adults and if it occurs in adults this may be due to poor hygiene and sanitation of the slaughterhouse workers.
Potensi Formulasi Self Microemulsifying Drug Delivery System (SMEDDS) Ekstrak Biji Kedelai (Glycine soja) Terhadap Penurunan Kolesterol pada Penyakit Jantung Koroner
Authors: Swastika I Nengah Raka , Ristiani Ni Ketut , Gorintha Adrian Wiryanata , Indrayani Agung Wiwiek 
Published: September 2021

Background: Coronary heart diseases (CHD) is a disorder that caused by blockage of coronary arteries due to the process of atherosclerosis which disrupts the blood supply to the heart muscle. According to Sample Registration System (SRS) Indonesia in 2014, CHD is a second highest cause of death after stroke that is 12,9% of all cause of death in Indonesia. Therefore, this study aims to examining the effect of soybean extract encapsulated with Self Microemulsifying Drug Delivery System (SMEDDS) on LDL levels in coronary heart model rats. Based on various study, isoflavone aglycone genistein is the main flavonoid in soybean seed that has potential as an antioxidant. To increase bioavailability of aglycone isoflavones, a SMEDDS is needed. In this regard, the purpose of this reseach is to examine the potential of soybean seed (Glycine soja) extract to reduced cholesterol in CHD.Methods: The method used is a literature review with literature sources in the form of relevant articles from the search engines, namely Google Scholar, Pubmed, ScienceDirect, and Research Gate. Inclusion criteria included journals containing the keywords “soybean (Glycine soja)”, “Coronary Heart Disease”, “SMEDDS”, and “genistein isoflavone aglycone”.Result: Isoflavone aglycone as an potential antioxidant that is able to bind free radicals and and also lowering LDL, Triglycerides, and glucose levels in hyperglycemic states and increasing HDL.Conclusion : Soybean seed extract with SMEDDS encapsulation have a potential to decrease LDL level in coronary heart disease.
The crystal structure of bis(2-oxidopyridin-1-ium-3-carboxylato-κ2
O,O′)-(phenantroline-κ2
N,N′)manganese(II) - methanol (1/3), C27H28N4O9Mn
Authors: Men Xiaoxia , Zhang Zhongyu , Li Xiaoli , Sun Weiqin 
Published: September 2021

Abstract
C27H28N4O9Mn, monoclinic, P21/n (no. 14), a = 10.0269(7) Å, b = 14.1702(10) Å, c = 20.0750(14) Å, β = 100.298(1)°, V = 2806.4(3) Å3, Z = 4, R

gt
(F) = 0.0403, wR

ref
(F
2) = 0.0985, T = 296.15 K.
Neuroscience meets cancer: networks and neuronal input to brain tumors
Authors: Venkataramani Varun , Karreman Matthia A. , Winkler Frank 
Published: September 2021

Abstract
The nervous system with its complex organizational features and functions is well-known for its impressive ability to process information and drive countless biological processes. It has come to the surprise of many that the nervous system can also be intimately involved in an unwelcome area of human life: the initiation and progression of cancer. For brain tumors, the parallels to neurodevelopment and nervous system function can be found on multiple levels. First, cancer cells of incurable gliomas interconnect with long cellular extensions to a large communicating multicellular network. Second, indirect and direct neuronal input can generate, activate, and control brain tumor growth. Third, it is becoming increasingly clear that those features not only drive brain tumor progression but also the notorious resistance of these tumors against standard antitumor therapies. Remarkably, these recent insights have already generated novel ideas for better antitumor therapies.
14N, 13C, and 119Sn solid-state NMR characterization of tin(II) carbodiimide Sn(NCN)
Authors: Jaworski Aleksander , Piątek Jędrzej , Mereacre Liuda , Braun Cordula , Slabon Adam 
Published: September 2021

Abstract
We report the first magic-angle spinning (MAS) nuclear magnetic resonance (NMR) study on Sn(NCN). In this compound the spatially elongated (NCN)2− ion is assumed to develop two distinct forms: either cyanamide (N≡C–N2−) or carbodiimide (−N=C=N−). Our 14N MAS NMR results reveal that in Sn(NCN) the (NCN)2− groups exist exclusively in the form of symmetric carbodiimide ions with two equivalent nitrogen sites, which is in agreement with the X-ray diffraction data. The 14N quadrupolar coupling constant

|

C
Q

|

$\vert {C}_{\text{Q}}\vert $

≈ 1.1 MHz for the −N=C=N− ion in Sn(NCN) is low when compared to those observed in molecular compounds that comprise cyano-type N≡C– moieties (

|

C
Q

|

$\vert {C}_{\text{Q}}\vert $

> 3.5 MHz). This together with the information from 14N and 13C chemical shifts indicates that solid-state NMR is a powerful tool for providing atomic-level insights into anion species present in these compounds. The experimental NMR results are corroborated by high-level calculations with quantum chemistry methods.
DNA methylation profiling reveals new potential subtype‐specific gene markers for early‐stage renal cell carcinoma in Caucasian population
Authors: Liko Alvaro Filbert , Ciputra Edward , Sanjaya Nathaniel Alvin , Thenaka Priskila Cherisca , Agustriawan David 
Published: September 2021

BackgroundRenal cell carcinoma (RCC) is among the top adult cancers worldwide, with a challenging management due to lack of early diagnosis, therapy resistance, and diverse molecular background. Aberrant DNA methylation has been associated with RCC development due to transcription deregulation. We discovered potential DNA methylation‐based biomarkers for stage I RCC in Caucasian population from The Cancer Genome Atlas (TCGA) database.MethodsPatients’ clinical, methylation beta‐value, and mRNA expression data were retrieved. Differential methylation and expression analysis were conducted to obtain differentially methylated CpG‐gene pairs. Inversely correlated CpG‐gene pairs between their expression and methylation levels were selected using Pearson’s correlation test and then screened for any recorded somatic mutations. Their biomarker capacities were analyzed using the Kaplan‐Meier and receiver operating characteristic analysis, followed by protein network and functional enrichment analysis.ResultsWe obtained differentially methylated CpGs in clear cell (KIRC) and papillary RCC (KIRP) but not chromophobe RCC (KICH). Six inversely correlated CpG‐gene pairs with no reported cancer‐associated mutations were selected. Prognostic values were found in ATXN1 and RFTN1 for KIRC, along with GRAMD1B and TM4SF19 for KIRP, while diagnostic values were found in VIM and RFTN1 for KIRC, along with TNFAIP6 and TM4SF19 for KIRP. Both subtypes showed enrichment of immune and metabolism‐related pathways.ConclusionWe discovered novel potential DNA methylation‐based prognostic and diagnostic markers for early‐stage RCC in Caucasian population. Validation by wet laboratory analysis and adjustments for confounding variables might be needed, considering our study limitation to specific race.
Progressive disseminated histoplasmosis in idiopathic CD4 lymphocytopenia an underdiagnosed combination - a case report
Authors: Yadav Prakrati , Kumar Deepak , Bohra Gopal Krishana , Garg Mahendra Kumar , Bharti Jyotsna N , Purohit Abhishek HL , Meena Durga Shankar 
Published: September 2021

Progressive disseminated histoplasmosis (PDH) usually presents as fever, anemia, leukopenia, hepatosplenomegaly, lymphadenopathy and pulmonary symptoms. There are few reports showed the association of Idiopathic CD4 lymphocytopenia (ICL) with histoplasmosis. We describe a 65-year-old female presented with history of fever, papulo-nodular rash and significant weight loss and diagnosed as progressive disseminated histoplasmosis. All immunocompromised conditions were ruled out. In addition, her 2 consecutive CD4 counts were below 300. The patient was diagnosed with PDH associated with ICL. Patient showed significant improvement with liposomal amphotericin B and itraconazole. Absolute CD4 counts should be done in all cases of progressive disseminated histoplasmosis even in HIV negative individuals to rule out associated ICL.
Thyroid carcinoma associated with other primary neoplasms, a single center study
Authors: Gabora Katalin , Bălăcescu Ovidiu , Trifa Adrian , Morariu Ana Maria , Pop Bogdan , Vișan Simona , Fetica Bogdan , Piciu Andra , Piciu Doina 
Published: September 2021

Background and aims. Thyroid carcinoma is the most frequent endocrine malignancy. It develops following a complex interaction of environmental and genetic factors. Its incidence is on the rise mostly due to the frequent diagnosis of microcarcinomas (tumor<1 cm ). In most cases, it has very good prognosis and survival rates. The incidence of a second primary malignancy in thyroid cancer patients is higher than in the general population. In this article, we focus on the role of BRAF V600E mutation in the development of other primary neoplasms associated with thyroid carcinoma.
Methods. This study was conducted in the department of Nuclear Medicine and Genetics of the "Prof. Dr. Ion Chiricuță” Institute of Oncology of Cluj-Napoca. We evaluated patients with thyroid carcinoma, who were diagnosed and treated for other malignancies such as breast, colorectal, lung cancer and malignant melanoma. In addition, we tested for the BRAF V600E mutation using paraffin samples of patients.
Results. We identified 17 patients that had thyroid carcinoma associated with other primary malignancies. Two of the patients included in the study had three associated primary cancers. The time interval between the diagnoses of two primary neoplasms in the same patient was 6.15 years, with a standard deviation (SD) of 5.39 years. The most common primary tumor associated with thyroid carcinoma in this study was breast cancer. We applied genetic testing for the BRAF V600E mutation in 12 patients. The BRAF V600E mutation positivity rate was 26.9% and most of the cancer associations were metachronous (occurring at least 6 months after thyroid cancer).
Conclusions. The BRAF V600E mutation is an important prognostic factor in the neoplasms included in this study, but its presence is not a predictive factor for the appearance of a metachronous or synchronous associated primary neoplasm to thyroid cancer.
Geoinformation technologies as a basis for research of the optimal location of general secondary education institutions (on the example of Chernivtsi city territorial community)
Authors: Zayachuk Myroslav D. , Kostashchuk Ivan I. , Darchuk Kostiantyn V. , Bilous Yurii O. 
Published: September 2021

GIS technologies allow an analyzis of large data sets at the lowest cost. To date, when forming a network of secondary schools, almost no geographic information systems have been used. GIS plays a special role in the study of transport and walking accessibility to GSEI. The article analyzes the theoretical, methodological and practical problems of using geographic information systems in studies of walking accessibility to general secondary schools of Chernivtsi city territorial community and describes the general secondary education institutions of the studied community. Based on geoinformation systems developed in Open Route Service and QGIS, the areas of the community with the best and worst walking accessibility to secondary schools were identified, which is certainly of great practical importance in creating pivotal institutions, their service zone and overcoming the problem of overcrowding in some schools. The most convenient location of the general secondary education institutions of Chernivtsi city territorial community was observed in the central part of the city, as well as in microdistricts Prospect and Boulevard, where there is a fairly dense arrangement of general secondary education institutions. There are also areas in the community that are outside the 2-kilometer walking accessibility zone and require transportation for students. Such areas are the Shantsi, Tsetsyno and Slobidka and Rohizna microdistricts, which have a cottage type accommodations. In general, most of the community is within walking accessibility. An important aspect of the location of GSEI is the availability indicator, which ranges 0.2 to 0.81. The average rate of accessibility to GSEI in the Chernivtsi city territorial community is 0.65. It should be noted that in the community there is a relevant problem of providing students with places in GSEI in those areas, where today the construction of new residential areas is actively carried out, while educational institutions are not expanding and not being built.