bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Sound and Stimulus Expectation on Transcranial Magnetic Stimulation-Elicited Motor Evoked Potentials
Authors: Capozio Antonio , Chakrabarty Samit , Astill Sarah 
Published: September 2021

AbstractThe amplitude of motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) over the motor cortex is influenced by multiple factors. TMS delivery is accompanied by an abrupt clicking noise which can induce a startle response. This study investigated how masking/attenuating the sound produced by the TMS system discharging influences MEP amplitudes. In addition, the effects of increasing the time between consecutive stimuli and of making participants aware of the time at which they would be stimulated were studied. MEPs were recorded from the Flexor Carpi Radialis (FCR) muscle at rest by stimulation at motor threshold (MT), 120% MT and 140% MT intensity. Participants (N = 23) received stimulation under normal (NORMAL) conditions and while: wearing sound-attenuating earmuffs (EAR); listening to white noise (NOISE); the interval between stimuli were prolonged (LONG); stimulation timing was presented on a screen (READY). The results showed that masking (p = 0.020) and attenuating (p = 0.004) the incoming sound significantly reduced the amplitude of MEPs recorded across the intensities of stimulation. Increasing the interval between pulses had no effect on the recorded traces if a jitter was introduced (p = 1), but making participants aware of stimulation timing decreased MEP amplitudes (p = 0.049). These findings suggest that the sound produced by TMS at discharging increases MEP amplitudes and that MEP amplitudes are influenced by stimulus expectation. These confounding factors need to be considered when using TMS to assess corticospinal excitability.
Measuring the impact of suspending Umrah, a global mass gathering in Saudi Arabia on the COVID-19 pandemic
Authors: Alshammari Sultanah M. , Almutiry Waleed K. , Gwalani Harsha , Algarni Saeed M. , Saeedi Kawther 
Published: September 2021

AbstractSince the early days of the coronavirus (COVID-19) outbreak in Wuhan, China, Saudi Arabia started to implement several preventative measures starting with the imposition of travel restrictions to and from China. Due to the rapid spread of COVID-19, and with the first confirmed case in Saudi Arabia in March 2019, more strict measures, such as international travel restriction, and suspension or cancellation of major events, social gatherings, prayers at mosques, and sports competitions, were employed. These non-pharmaceutical interventions aim to reduce the extent of the epidemic due to the implications of international travel and mass gatherings on the increase in the number of new cases locally and globally. Since this ongoing outbreak is the first of its kind in the modern world, the impact of suspending mass gatherings on the outbreak is unknown and difficult to measure. We use a stratified SEIR epidemic model to evaluate the impact of Umrah, a global Muslim pilgrimage to Mecca, on the spread of the COVID-19 pandemic during the month of Ramadan, the peak of the Umrah season. The analyses shown in the paper provide insights into the effects of global mass gatherings such as Hajj and Umrah on the progression of the COVID-19 pandemic locally and globally.
Neglected Pragmatism: Discussing Abduction to Dissolute Classical Dichotomies
Authors: Sans Pinillos Alger 
Published: September 2021

AbstractMany parts of the contemporary philosophical debate have been built on the radicalization of conclusions derived from the acceptance of a certain set of classical dichotomies. It also discusses how pragmatism and abduction are currently presented to solve the problems arising from these dichotomies. For this reason, the efforts of this article have been directed to analyze the impact of this fact on the philosophy of science and logic. The starting point is that accepting abduction implies, in many ways, accepting the foundations of pragmatism. Also, that the analysis of such problems from pragmatism and the particular use of abduction dissolve the dichotomies and, with it, also modify the philosophical problems related to them. Therefore, I propose to understand abduction as the right conceptual device to review the problems and debates of the twentieth century’s epistemology from a pragmatic perspective. In doing so, the aim is to propose that the current use of abduction in contemporary debates may imply a change of the philosophical perspective.
Partial mowing of urban lawns supports higher abundances and diversities of insects
Authors: Wintergerst Jennifer , Kästner Tommy , Bartel Manuela , Schmidt Christian , Nuss Matthias 
Published: September 2021

AbstractWithin the citizen science project “Flowering meadows for Saxonian butterflies”, more than 640 meadows are partially and at maximum three times annually mowed in order to change urban lawns into habitats for insects. In 2019, insect diversity was evaluated using the 100 sweep net technique during five visits at nine butterfly meadows (BM) and nine intensively mowed lawns (IML). The mean arthropod biomass of these five visits per site is significantly higher on BM compared to IML. All adult individuals of Apidae, Coleoptera, Heteroptera, Orthoptera, Papilionoidea as well as Asilidae and Syrphidae have been identified morphologically, revealing 260 species from all study sites. The mean number of species per visit is significantly higher on BM compared to IML. 90 species are recorded as larva and the mean number of species per visit is significantly higher on BM compared to IML. 42 species are recorded as larva as well as adult. The records of larvae provide evidence for reproduction on the meadows.Implications for insect conservationOur results clearly demonstrate that a reduced mowing frequency together with an always partial mowing of the area support higher biomass, abundances and diversities of insects as well as reproduction of insects on urban lawns. Therefore, reduced mowing frequency together with partial mowing is recommended for urban lawns as well as meadows in the countryside and conservation areas to foster insect diversity.
Meaning-Preserving Translations of Non-classical Logics into Classical Logic: Between Pluralism and Monism
Authors: Schurz Gerhard 
Published: September 2021

AbstractIn order to prove the validity of logical rules, one has to assume these rules in the metalogic. However, rule-circular ‘justifications’ are demonstrably without epistemic value (sec. 1). Is a non-circular justification of a logical system possible? This question attains particular importance in view of lasting controversies about classical versus non-classical logics. In this paper the question is answered positively, based on meaning-preserving translations between logical systems. It is demonstrated that major systems of non-classical logic, including multi-valued, paraconsistent, intuitionistic and quantum logics, can be translated into classical logic by introducing additional intensional operators into the language (sec. 2–5). Based on this result it is argued that classical logic is representationally optimal. In sec. 6 it is investigated whether non-classical logics can be likewise representationally optimal. The answer is predominantly negative but partially positive. Nevertheless the situation is not symmetric, because classical logic has important ceteris paribus advantages as a unifying metalogic.
Augmented reality flavor: cross-modal mapping across gustation, olfaction, and vision
Authors: Halabi Osama , Saleh Mohammad 
Published: September 2021

AbstractGustatory display research is still in its infancy despite being one of the essential everyday senses that human practice while eating and drinking. Indeed, the most important and frequent tasks that our brain deals with every day are foraging and feeding. The recent studies by psychologists and cognitive neuroscientist revealed how complex multisensory rely on the integration of cues from all the human senses in any flavor experiences. The perception of flavor is multisensory and involves combinations of gustatory and olfactory stimuli. The cross-modal mapping between these modalities needs to be more explored in the virtual environment and simulation, especially in liquid food. In this paper, we present a customized wearable Augmented Reality (AR) system and olfaction display to study the effect of vision and olfaction on the gustatory sense. A user experiment and extensive analysis conducted to study the influence of each stimulus on the overall flavor, including other factors like age, previous experience in Virtual Reality (VR)/AR, and beverage consumption. The result showed that smell contributes strongly to the flavor with less contribution to the vision. However, the combination of these stimuli can deliver richer experience and a higher belief rate. Beverage consumption had a significant effect on the flavor belief rate. Experience is correlated with stimulus and age is correlated with belief rate, and both indirectly affected the belief rate.
Microencapsulation of Phenolic Extracts from Cocoa Shells to Enrich Chocolate Bars
Authors: Grassia M. , Messia M.C. , Marconi E. , Demirkol Ȫ. Şakiyan , Erdoğdu F. , Sarghini F. , Cinquanta L. , Corona O. , Planeta D. 
Published: September 2021

AbstractCocoa bean shells were subjected to green extraction technologies, based on the absence of toxic organic solvents, to recover polyphenols; the extract was then encapsulated using a spray dryer and maltodextrin as coating agent. The best conditions observed in the spray drying tests (core-to-coating ratio 1:5; inlet temperature 150 °C; flow rate 6 ml min−1) were applied to produce the microcapsules used to enrich the same cocoa mass as the shells and processed for the preparation of the chocolate bars. Sensory analysis showed no significant differences between enriched chocolate bar and the unenriched reference one, except for the appearance. Both samples were then subjected to accelerated storage tests, at the end of which the polyphenols in the control chocolate bar (0.85 g 100 g−1) were reduced by about 50% (0.42 g 100 g−1), while in the enriched chocolate (1.17 g 100 g−1) by only 22% (0.97 g 100 g−1). The proposed process significantly enriched the chocolate bars with phenolic antioxidants recovered from cocoa waste without increasing the sensations of bitterness and astringency.
Epigenetic clock and methylation studies in the rhesus macaque
Authors: Horvath Steve , Zoller Joseph A. , Haghani Amin , Jasinska Anna J. , Raj Ken , Breeze Charles E. , Ernst Jason , Vaughan Kelli L. , Mattison Julie A. 
Published: September 2021

AbstractMethylation levels at specific CpG positions in the genome have been used to develop accurate estimators of chronological age in humans, mice, and other species. Although epigenetic clocks are generally species-specific, the principles underpinning them appear to be conserved at least across the mammalian class. This is exemplified by the successful development of epigenetic clocks for mice and several other mammalian species. Here, we describe epigenetic clocks for the rhesus macaque (Macaca mulatta), the most widely used nonhuman primate in biological research. Using a custom methylation array (HorvathMammalMethylChip40), we profiled n = 281 tissue samples (blood, skin, adipose, kidney, liver, lung, muscle, and cerebral cortex). From these data, we generated five epigenetic clocks for macaques. These clocks differ with regard to applicability to different tissue types (pan-tissue, blood, skin), species (macaque only or both humans and macaques), and measure of age (chronological age versus relative age). Additionally, the age-based human-macaque clock exhibits a high age correlation (R = 0.89) with the vervet monkey (Chlorocebus sabaeus), another Old World species. Four CpGs within the KLF14 promoter were consistently altered with age in four tissues (adipose, blood, cerebral cortex, skin). Future studies will be needed to evaluate whether these epigenetic clocks predict age-related conditions in the rhesus macaque.
Octonionic Kerzman–Stein Operators
Authors: Constales Denis , Kraußhar Rolf Sören 
Published: September 2021

AbstractIn this paper we consider generalized Hardy spaces in the octonionic setting associated to arbitrary Lipschitz domains where the unit normal field exists almost everywhere. First we discuss some basic properties and explain structural differences to the associative Clifford analysis setting. The non-associativity requires special attention in the definition of an appropriate inner product and hence in the definition of a generalized Szegö projection. Whenever we want to apply classical theorems from reproducing kernel Hilbert spaces we first need to switch to the consideration of real-valued inner products where the Riesz representation theorem holds. Then we introduce a generalization of the dual Cauchy transform for octonionic monogenic functions which represents the adjoint transform with respect to the real-valued inner product$$\langle \cdot , \cdot \rangle _0$$⟨·,·⟩0together with an associated octonionic Kerzman–Stein operator and related kernel functions. Also in the octonionic setting, the Kerzman–Stein operator that we introduce turns out to be a compact operator. A motivation behind this approach is to find an approximative method to compute the Szegö projection of octonionic monogenic functions offering a possibility to tackle BVP in the octonions without the explicit knowledge of the octonionic Szegö kernel which is extremely difficult to determine in general. We also discuss the particular cases of the octonionic unit ball and the half-space. Finally, we relate our octonionic Kerzman–Stein operator to the Hilbert transform and particularly to the Hilbert–Riesz transform in the half-space case.
Juice chemical properties of 24 sorghum cultivars under varying levels of sugarcane aphid (Melanaphis sacchari) infestation
Authors: Knoll Joseph E. , Uchimiya Minori , Harris-Shultz Karen 
Published: September 2021

AbstractSugarcane aphids [Melanaphis sacchari (Zehntner)] have become a significant pest of grain, forage, and sweet sorghum [Sorghum bicolor (L.) Moench] in the USA in recent years. However, the effects of sugarcane aphid damage on sweet sorghum juice quality have not been well studied. A three-year (2015–2017) field study was conducted at Tifton, GA to assess planting date effects (April, May, or June planting) and cultivar responses (24 cultivars) to sugarcane aphids in sorghum. Aphid damage ratings were measured in all three years and cumulative aphid days were measured in 2016 and 2017. Cumulative aphid days (ln scale) and damage ratings (relative marginal effect) were correlated in five of the six plantings. Stem juice was collected at maturity from seven plantings for chemical analyses, which included HPLC, fluorescence excitation-emission spectrophotometry with parallel factor analysis (EEM/PARAFAC), and cyclic voltammetry (CV). Aphid damage ratings and cumulative aphid days were negatively correlated with sugar-related traits, particularly brix and total sugars. In four plantings, significant negative correlations (r ≤ −0.493) between trans-aconitic acid concentration and aphid damage were observed. Fluorescence and electrochemical properties related to the presence of polyphenols also showed correlations with aphid damage, particularly in the resistant landrace No. 5 Gambela. These secondary metabolites may play a role in sugarcane aphid resistance or tolerance. Stability analysis revealed that the more tolerant cultivars were able to maintain high concentrations of total sugars and trans-aconitic acid across environments.
Analysis of Post-operative Adjuvant Chemotherapy Versus Adjuvant Chemoradiation Therapy Outcomes in Non-metastatic Cholangiocarcinoma: an NCDB Review
Authors: Rodriguez Robin R. , Abel Stephen , Mamadgi Jyothika , Renz Paul B. , Wegner Rodney E. , Raj Moses S. 
Published: September 2021

Abstract
Background
Each year, approximately 8000 cases of cholangiocarcinoma are recorded in the USA. Surgical resection is considered to be the only curative option. Despite surgery as a curative approach, many patients will require adjuvant therapies in the form of chemotherapy (ChT) or chemoradiotherapy (CRT). As such, we sought to analyze outcomes in patients with non-metastatic cholangiocarcinoma receiving adjuvant ChT or CRT following surgical resection.

Methods
We queried the National Cancer Database (NCDB) for patients with a diagnosis of non-metastatic cholangiocarcinoma between the years 2010 and 2015 who underwent adjuvant ChT or CRT following surgery. Overall survival (OS) was calculated using Kaplan Meier method. Cox proportional hazard ratios were used to identify predictors of overall survival, and logistic regression was used to identify predictors of receiving each treatment.

Results
A total of 875 patients were identified who met the above eligibility criteria. Of these patients, 818 received adjuvant chemotherapy alone with 57 patients receiving adjuvant chemoradiation therapy. The median OS in patients receiving CRT was 19.8 months versus 11.9 months for ChT (p value < 0.0238). The 1- and 5-year survival rates between ChT and CRT were 50% vs 61% and 6% vs 13%, respectively (hazard ratio 0.7005; 95% CI 0.51–0.97; p value < 0.0294).

Conclusion
The results of this study suggest a potential benefit of chemoradiation therapy in the adjuvant setting, although the trends appear to show rare utilization. Given the limitations of our study, prospective corroboration is warranted.
Thermal building upgrade with off-grid PV system: a Polish case
Authors: Wciślik Sylwia , Kotrys-Działak Dagmara 
Published: September 2021

AbstractNowadays, one of the basic requirements for thermally upgraded buildings involves limitation in CO2 emission even by over 90%. To fulfil these criteria, it is necessary to use alternative energy sources and photovoltaics constitutes a reasonable option for this. This paper addresses an analysis of the efficiency and profitability of a photovoltaic system located in the geometric center of Europe-Poland, where the intensity of solar irradiation is not very high compared to other European countries. The difference of total solar radiation density between Poland and Malta is 49.2%, from analysis based on SolarGIS base. The PV Lighthouse calculator was used for global power density and photon current examination for a Polish city and locations of the highest and the lowest solar radiation values, Malta and Finland, respectively. This case study concerns a thermally upgraded building; a gas boiler was replaced by a heat pump supported by an off-grid PV system. To achieve a reduction in CO2 emission of 90%, it is necessary to install 182 PV cells, which generates high investment costs. An investment is entirely profitable with 70% of funding with Simple Pay Back Time, SPBT~7 years although Net Present Value, NPV>0; Internal Rate of Return, IRR=10.6%.
Stigma and life satisfaction among out-of-school Korean youth: the mediating roles of self-esteem and depressive symptoms
Authors: Cho Myong Sun 
Published: September 2021

AbstractThe purpose of this study was to assess the extent to which self-esteem and depressive symptoms mediated the influence of stigma on life satisfaction among out-of-school youth in the Republic of Korea. Cross-sectional data were collected from 318 youth, aged 18 to 23 years (20.67 ± 1.12), who provided information on perceived stigma, self-esteem, depressive symptoms, life satisfaction, and personal characteristics. A hierarchical linear regression analysis was followed by a path analysis to investigate the mediation effects. Stigma was found to be negatively associated with life satisfaction. Self-esteem mediated the negative association between stigma and life satisfaction, while depressive symptoms mediated the positive association between stigma and life satisfaction. The path analysis results showed that the influence of depressive symptoms on life satisfaction had the largest path coefficient (β = −0.60, p < .01) and the influence of self-esteem on life satisfaction also has a large path coefficient (β = 0.52, p < .01). This study demonstrated that self-esteem and depressive symptoms are important to the relationship between stigma and life satisfaction. Implications are discussed regarding possible stigma-reduction strategies and interventions to help out-of-school youth integrate into society and lead successful and satisfying lives.
Impact of weather conditions and building design on contaminant infiltration from crawl spaces in Swedish schools—Numerical modeling using Monte Carlo method
Authors: Domhagen Fredrik , Wahlgren Paula , Hagentoft Carl-Eric 
Published: September 2021

AbstractSome Swedish school buildings built in the 1960s and 1970s experience indoor air quality problems, where the contaminants are suspected to come from the crawl space underneath the building. The poor indoor air quality causes discomfort among pupils and teachers. Installing an exhaust fan to maintain a negative pressure difference in the crawl space relative to indoors or increasing the ventilation in the classroom are two examples of common measures taken to improve the indoor air quality. However, these measures are not always effective, and sometimes the school building has to be demolished. The relation between pressure distribution, contaminant concentration in the classroom, outdoor temperature, wind, mechanical ventilation, and air leakage distribution is complex. A better understanding of these relations is crucial for making decisions on the most efficient measure to improve the indoor air quality. In this paper, a model for contaminant infiltration from the crawl space is used together with the Monte Carlo method to study these relations. Simulations are performed for several cases where different building shapes, building orientations, shielding conditions, and geographical locations are simulated. Results show, for example, that for a building with an imbalanced ventilation system, air is leaking from the crawl space to the classroom for the majority of cases and that concentration levels in the classroom are usually the highest during mild and calm days.
Blaaskatheterisatie in historisch perspectief
Authors: Berendsen Sophie A. , Coolen Rosa L. , van Doorn Tess , Blok Bertil F. M. 
Published: September 2021

SamenvattingDit artikel geeft een overzicht van blaaskatheterisatie in Nederland tussen 1997 en 2018. Voor het maken van het overzicht is gebruikgemaakt van een databank met declaratie-informatie over extramurale hulpmiddelenzorg onder de verzekerde bevolking. Het aantal gebruikers wordt weergegeven per 100.000 personen. Het gebruik van verblijfskatheters is toegenomen van 159 (24.734 gebruikers) in 1997 naar 315 gebruikers per 100.000 personen (54.106 gebruikers) in 2018. Het gebruik van wegwerpkatheters verdrievoudigde van 92 (14.258 gebruikers) in 1997 naar 267 per 100.000 personen (45.909 gebruikers) in 2018. In 2018 had 20,7 % van de gebruikers een neurogeen en 44,9 % een niet-neurogeen onderliggend lijden. De totale kosten stegen van 27,7 naar 84,4 miljoen euro. De kosten voor intermitterende katheterisatie stegen het meest: van 16,4 naar 74,6 miljoen euro. Uit dit onderzoek blijkt dat in de afgelopen 21 jaar het gebruik van verblijfskatheters en wegwerpkatheters substantieel is toegenomen. Mogelijk komt dit door de stijging van incontinentiezorg bij ouderen en dat aan richtlijnen is toegevoegd dat intermitterende katheterisatie de voorkeur heeft boven een verblijfskatheter.