bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stratiform Cloud-Hydrometeor Assimilation for HRRR and RAP Model Short-Range Weather Prediction
Authors: Benjamin Stanley G. , James Eric P. , Hu Ming , Alexander Curtis R. , Ladwig Therese T. , Brown John M. , Weygandt Stephen S. , Turner David D. , Minnis Patrick , Smith William L. , Heidinger Andrew K. 
Published: June 2021

AbstractAccurate cloud and precipitation forecasts are a fundamental component of short-range data assimilation/model prediction systems such as the NOAA 3-km High-Resolution Rapid Refresh (HRRR) or the 13-km Rapid Refresh (RAP). To reduce cloud and precipitation spin-up problems, a non-variational assimilation technique for stratiform clouds was developed within the Gridpoint Statistical Interpolation (GSI) data assimilation system. One goal of this technique is retention of observed stratiform cloudy and clear 3D volumes into the subsequent model forecast. The cloud observations used include cloud-top data from satellite brightness temperatures, surface-based ceilometer data, and surface visibility. Quality control, expansion into spatial information content, and forward operators are described for each observation type. The projection of data from these observation types into an observation-based cloud-information 3D gridded field is accomplished via identification of cloudy, clear, and cloud-unknown 3D volumes. Updating of forecast background fields is accomplished through clearing and building of cloud water and cloud ice with associated modifications to water vapor and temperature. Impact of the cloud assimilation on short-range forecasts is assessed with a set of retrospective experiments in warm and cold seasons using the RAPv5 model. Short-range (1-9h) forecast skill is improved in both seasons for cloud ceiling and visibility and for 2-m temperature in daytime and with mixed results for other measures. Two modifications were introduced and tested with success: use of prognostic subgrid-scale cloud fraction to condition cloud building (in response to a high bias) and removal of a WRF-based rebalancing.
Examining Disparities in Food Access Between Historically Black Colleges and Universities and Non-Historically Black Colleges and Universities
Authors: Kornbluh Mariah , Hallum Shirelle , Wende Marilyn , Ray Joseph , Herrnstadt Zachary , Kaczynski Andrew T. 
Published: June 2021

Purpose: Examine if Historically Black Colleges and Universities (HBCUs) are more likely to be located in low food access area (LFA) census tracts compared to public non-HBCUs. Design: ArcGIS Pro was utilized to capture food environments and census tract sociodemographic data. Setting: The sample included 98 HBCUs and 777 public non-HBCUs within the United States. 28.9% of study census tracts were classified as LFA tracts. Measures: University data were gathered from the National Center for Education Statistics. Census tract-level LFA classification was informed by the United States Department of Agriculture’s Food Access Research Atlas. Covariates included population density and neighborhood socioeconomic status of census tracts containing subject universities. Analysis: Multilevel logistic regression was employed to examine the relationship between university type and LFA classification. Results: A higher percentage of HBCUs (46.9%) than public non-HBCUs (26.6%) were located in LFAs. After adjusting for population density and neighborhood socioeconomic status, university type was significantly associated with food access classification (B=0.71;p=.0036). The odds of an HBCU being located in LFA tracts were 104% greater than for a public non-HBCU (OR=2.04;95% CI=1.26,3.29). Conclusion: Findings underscore the need for policy interventions tailored to HBCU students to promote food security, environmental justice, and public health.
Gender-specific cut-off levels in colorectal cancer screening with fecal immunochemical test: A population-based study of colonoscopy findings and costs
Authors: Ribbing Wilén Hanna , Saraste Deborah , Blom Johannes 
Published: June 2021

Objective In the population-based Swedish regional colorectal cancer (CRC) screening program of Stockholm–Gotland using the fecal immunochemical test (FIT), gender-specific cut-off levels of fecal hemoglobin are applied, since previous studies have indicated a lower sensitivity of FIT for CRC in women. The aim was to evaluate the diagnostic yield and the screening costs overall and per detected CRC of this strategy. Methods All individuals aged 60–69 invited to screening in 2015–2017 were included. Cut-off level for positive FIT was 40 µg/g in women and 80 µg/g in men. Those with a positive FIT were referred to colonoscopy. The yield of CRC and screening cost for the study period were assessed and compared to cut-off levels of 80 µg/g in both genders. Results Approximately 230,000 individuals were invited. Overall participation rates were 72% in women and 65% in men ( p < 0.05). FIT was positive in 4256 individuals (2.7% in both genders). In 3758 colonoscopies, 258 (6.9%) CRCs were detected. The positive predictive value for CRC was significantly higher in men (8.3% vs. 5.8%). In 120 women with CRC, 28 (23%) had FIT < 80 µg/g. Negative colonoscopies were more common in women (24% vs. 17%, p < 0.05). Total costs for the study period were 52,000,000SEK (≈5,200,000€), i.e. 16% higher compared to using cut-off levels of 80 µg/g in both genders, and corresponding to a 3% increment in cost per detected CRC. Conclusion The high rate of CRC detected in women in the lowest FIT category outweighs the minor reduction in screening costs if the same cut-off level was used as for men.
Comparison of three regional anaesthetic techniques for infraorbital or maxillary nerve block in cats: a cadaveric study
Authors: Shilo-Benjamini Yael , Letz Shachar , Peery Dana , Abu Ahmad Wiessam , Bar-Am Yoav 
Published: June 2021

Objectives The maxillary nerve courses very close to the globe, rendering cats – with their large eyes – at risk of globe penetration during infraorbital or maxillary nerve blocks. Therefore, the goals of the study were to compare the distribution and potential complications of three infraorbital or maxillary regional injection techniques. Methods Twenty-three bilateral maxillae of cat cadavers were used in a randomised blinded trial. Each maxilla was injected with a 0.2 ml 1:1 mixture of lidocaine 2% and a contrast medium by one of three injection techniques: infraorbital foramen (IOF; n = 14); infraorbital canal (IOC; n = 16); or maxillary foramen (MF; transpalpebral approach; n = 16) using a 25 G 1.6 cm needle. CT imaging of each cadaver head was performed before and after injections. A radiologist scored injectate distribution (none [0], mild [1], moderate [2], large [3]) in four locations: rostral, central and caudal IOC, and at the MF, for which the distribution side was also determined. Comparisons were performed with ordinal logistic mixed effects ( P <0.05). Results The median (range) total distribution score of the IOC and MF technique were significantly higher compared with the IOF technique (6.5 [4–12], 4 [2–8] and 0 [0–10], respectively). The total IOC score was also significantly higher compared with the MF technique. Injectate distribution at the MF was significantly more central following IOC injection compared with MF injection, which distributed centrolaterally. None of the techniques resulted in intraocular injection. Conclusions and relevance The IOC and MF techniques produced a satisfactory spread of the mixture that could result in effective maxillary anaesthesia in cats. Further studies are required to determine the effectiveness and safety of these techniques.
A significant change towards cemented fixation in revision total hip arthroplasty in patients younger than 55 years in the Netherlands: results of an observational cohort study in the Dutch Arthroplasty Register in 28,516 primary hip replacements and 1285 revision procedures
Authors: Kuijpers Martijn FL , Hannink Gerjon , van Steenbergen Liza N , Schreurs B Wim 
Published: June 2021

Background: Worldwide, the majority of total hip arthroplasties (THAs) placed in patients <55 years are uncemented. However, little is known about the preferred method of fixation in revision hip arthroplasty in young patients. The aim of this study was to assess potential differences in the method of fixation used between primary and revision THA in young patients using data from the Dutch Arthroplasty Register. Methods: All primary THA placed in patients younger than 55 years, registered in the LROI between 2007 and 2019 were included n = 28,516). Kaplan-Meier survival analyses were used to estimate the survival of primary THA by method of fixation. Additionally, survival of revision procedures that changed or did not change in method of fixation were estimated. McNemar’s test was used to assess differences in the proportion of cemented and uncemented fixation between primary and revision THA. Results: In all acetabular revisions, the use of cemented fixation increased statistically significant with 39% (95% CI, 34–45, p < 0.001) from 23% in primary THA to 62% in revision procedures. In all femoral revisions, the increase of cemented fixation was also statistically significant with 25% (95% CI, 19–31, p < 0.001), from 11% in primary THA to 36% in revision surgery. For both revised acetabular and femoral components, we found no statistically significant difference in the 5-year survival between revision procedures that changed or did not change in method of fixation. Conclusions: There was a significant change towards cemented fixation between primary and revision THA in young patients in the Netherlands, which was especially pronounced in acetabular revisions. No significant difference in short-term survival was found between revision procedures that changed or did not change in method of fixation. Long-term follow-up data are needed to evaluate the effect of this change in fixation method on the outcome of revision procedures in young patients.
COVID-19 vaccine acceptance among high-risk populations in Uganda
Authors: Bongomin Felix , Olum Ronald , Andia-Biraro Irene , Nakwagala Frederick Nelson , Hassan Khalid Hudow , Nassozi Dianah Rhoda , Kaddumukasa Mark , Byakika-Kibwika Pauline , Kiguli Sarah , Kirenga Bruce J. 
Published: June 2021

Background: Immunization is an important strategy for controlling the COVID-19 pandemic. COVID-19 vaccination was recently launched in Uganda, with prioritization to healthcare workers and high-risk individuals. In this study, we aimed to determine the acceptability of COVID-19 vaccine among persons at high risk of COVID-19 morbidity and mortality in Uganda. Methods: Between 29 March and 14 April 2021, we conducted a cross-sectional survey consecutively recruiting persons at high risk of severe COVID-19 (diabetes mellitus, HIV and cardiovascular disease) attending Kiruddu National Referral Hospital outpatient clinics. A trained research nurse administered a semi-structured questionnaire assessing demographics, COVID-19 vaccine related attitudes and acceptability. Descriptive statistics, bivariate and multivariable analyses were performed using STATA 16. Results: A total of 317 participants with a mean age 51.5 ± 14.1 years were recruited. Of this, 184 (60.5%) were female. Overall, 216 (70.1%) participants were willing to accept the COVID-19 vaccine. The odds of willingness to accept COVID-19 vaccination were four times greater if a participant was male compared with if a participant was female [adjusted odds ratio (AOR): 4.1, 95% confidence interval (CI): 1.8–9.4, p = 0.00]. Participants who agreed (AOR: 0.04, 95% CI: 0.01–0.38, p = 0.003) or strongly agreed (AOR: 0.04, 95% CI: 0.01–0.59, p = 0.005) that they have some immunity against COVID-19 were also significantly less likely to accept the vaccine. Participants who had a history of vaccination hesitancy for their children were also significantly less likely to accept the COVID-19 vaccine (AOR: 0.1, 95% CI: 0.01–0.58, p = 0.016). Conclusion: The willingness to receive a COVID-19 vaccine in this group of high-risk individuals was comparable to the global COVID-19 vaccine acceptance rate. Increased sensitization, myth busting and utilization of opinion leaders to encourage vaccine acceptability is recommended.
Specific detection of high mobility group box 1 degradation product with a novel ELISA
Authors: Totoki Takaaki , Ito Takashi , Yamada Shingo , Honda Goichi , Hattori Tsuyoshi , Maruyama Ikuro 
Published: June 2021

Abstract
Background
During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inflammation and remote organ failure. The proinflammatory effects of HMGB1 can be suppressed by recombinant thrombomodulin (rTM), in part through a mechanism involving thrombin–rTM-mediated degradation of HMGB1. Given that HMGB1 is proinflammatory but the HMGB1 degradation product (desHMGB1) is not, an analytical method that discriminates between these two molecules may provide a more in-depth understanding of HMGB1-induced pathogenicity as well as rTM-mediated therapeutic efficiency.

Methods
A peptide that has a shared amino-terminal structure with desHMGB1 was synthesized. C3H/lpr mice were immunized with the desHMGB1 peptide conjugate, and antibody-secreting hybridoma cells were developed using conventional methods. The reactivity and specificity of the antibodies were then analyzed using antigen-coated enzyme-linked immunosorbent assay (ELISA) as well as antibody-coated ELISA. Next, plasma desHMGB1 levels were examined in a cecal ligation and puncture (CLP)-induced septic mouse model treated with rTM.

Results
Through a series of screening steps, we obtained a monoclonal antibody that recognized desHMGB1 but did not recognize intact HMGB1. ELISA using this antibody specifically detected desHMGB1, which was significantly increased in CLP-induced septic mice treated with rTM compared with those treated with saline.

Conclusions
In this study, we obtained a desHMGB1-specific monoclonal antibody. ELISA using the novel monoclonal antibody may be an option for the in-depth analysis of HMGB1-induced pathogenicity as well as rTM-mediated therapeutic efficiency.
An Intelligent Fault Diagnosis Method of Multi-Scale Deep Feature Fusion Based on Information Entropy
Authors: Shang Zhiwu , Li Wanxiang , Gao Maosheng , Liu Xia , Yu Yan 
Published: June 2021

AbstractFor a single-structure deep learning fault diagnosis model, its disadvantages are an insufficient feature extraction and weak fault classification capability. This paper proposes a multi-scale deep feature fusion intelligent fault diagnosis method based on information entropy. First, a normal autoencoder, denoising autoencoder, sparse autoencoder, and contractive autoencoder are used in parallel to construct a multi-scale deep neural network feature extraction structure. A deep feature fusion strategy based on information entropy is proposed to obtain low-dimensional features and ensure the robustness of the model and the quality of deep features. Finally, the advantage of the deep belief network probability model is used as the fault classifier to identify the faults. The effectiveness of the proposed method was verified by a gearbox test-bed. Experimental results show that, compared with traditional and existing intelligent fault diagnosis methods, the proposed method can obtain representative information and features from the raw data with higher classification accuracy.
Oil Film Stiffness of Double Involute Gears Based on Thermal EHL Theory
Authors: Yin Zhaoming , Fan Zhimin , Jiang Feng 
Published: June 2021

AbstractLubrication failure is one of the main failure forms of gear failure. Time varying meshing stiffness is an important factor affecting the dynamic behavior of gears. However, the influence of oil film stiffness is usually ignored in the research process. In this paper, according to the meshing characteristics of double involute gears, based on the non-Newtonian thermal EHL theory, a new calculation method of normal and tangential oil film stiffness for double involute gears is established by the idea of subsection method. The oil film stiffness difference between double involute gears and common involute gears is analyzed, and the influence of tooth waist order parameters, working conditions, and thermal effect on the oil film stiffness are studied. The results reveal that there are some differences between normal and tangential oil film stiffness between double involute gears and common involute gears, but there is little difference. Compared with the torque, rotation speed and initial viscosity of the lubricating oil, the tooth waist order parameters have less influence on the oil film stiffness. Thermal effect has a certain influence on normal and tangential oil film stiffness, which indicates that the influence of thermal effect on the oil film can not be ignored. This research proposes a calculation method of normal and tangential oil film stiffness suitable for double involute gears, which provides a theoretical basis for improving the stability of the transmission.
Global investigation of estrogen-responsive genes regulating lipid metabolism in the liver of laying hens
Authors: Ren Junxiao , Tian Weihua , Jiang Keren , Wang Zhang , Wang Dandan , Li Zhuanjian , Yan Fengbin , Wang Yanbin , Tian Yadong , Ou Kepeng , Wang Hongjun , Kang Xiangtao , Li Hong , Liu Xiaojun 
Published: June 2021

Abstract
Background
Estrogen plays an essential role in female development and reproductive function. In chickens, estrogen is critical for lipid metabolism in the liver. The regulatory molecular network of estrogen in chicken liver is poorly understood. To identify estrogen-responsive genes and estrogen functional sites on a genome-wide scale, we determined expression profiles of mRNAs, lncRNAs, and miRNAs in estrogen-treated ((17β-estradiol)) and control chicken livers using RNA-Sequencing (RNA-Seq) and studied the estrogen receptor α binding sites by ChIP-Sequencing (ChIP-Seq).

Results
We identified a total of 990 estrogen-responsive genes, including 962 protein-coding genes, 11 miRNAs, and 17 lncRNAs. Functional enrichment analyses showed that the estrogen-responsive genes were highly enriched in lipid metabolism and biological processes. Integrated analysis of the data of RNA-Seq and ChIP-Seq, identified 191 genes directly targeted by estrogen, including 185 protein-coding genes, 4 miRNAs, and 2 lncRNAs. In vivo and in vitro experiments showed that estrogen decreased the mRNA expression of PPARGC1B, which had been reported to be linked with lipid metabolism, by directly increasing the expression of miR-144-3p.

Conclusions
These results increase our understanding of the functional network of estrogen in chicken liver and also reveal aspects of the molecular mechanism of estrogen-related lipid metabolism.
Hybridization and introgression in sympatric and allopatric populations of four oak species
Authors: Li Xuan , Wei Gaoming , El-Kassaby Yousry A. , Fang Yanming 
Published: June 2021

Abstract
Background
Hybridization and introgression are vital sources of novel genetic variation driving diversification during reticulated evolution. Quercus is an important model clade, having extraordinary diverse and abundant members in the Northern hemisphere, that are used to studying the introgression of species boundaries and adaptive processes. China is the second-largest distribution center of Quercus, but there are limited studies on introgressive hybridization.

Results
Here, we screened 17 co-dominant nuclear microsatellite markers to investigate the hybridization and introgression of four oaks (Quercus acutissima, Quercus variabilis, Quercus fabri, and Quercus serrata) in 10 populations. We identified 361 alleles in the four-oak species across 17 loci, and all loci were characterized by high genetic variability (HE = 0.844–0.944) and moderate differentiation (FST = 0.037–0.156) levels. A population differentiation analysis revealed the following: allopatric homologous (FST = 0.064) < sympatric heterogeneous (FST = 0.071) < allopatric heterogeneous (FST = 0.084). A Bayesian admixture analysis determined four types of hybrids (Q. acutissima × Q. variabilis, Q. fabri × Q. serrata, Q. acutissima × Q. fabri, and Q. acutissima × Q. variabilis × Q. fabri) and their asymmetric introgression. Our results revealed that interspecific hybridization is commonly observed within the section Quercus, with members having tendency to hybridize.

Conclusions
Our study determined the basic hybridization and introgression states among the studied four oak species and extended our understanding of the evolutionary role of hybridization. The results provide useful theoretical data for formulating conservation strategies.
The provision of dementia care in general practice: practice nurse perceptions of their role
Authors: Gibson Caroline , Goeman Dianne , Hutchinson Alison , Yates Mark , Pond Dimity 
Published: June 2021

Abstract
Background
Primary care nurses can assist General Practitioner’s to identify cognition concerns and support patient health self-management for those experiencing cognitive impairment or dementia. This support may lead to more appropriate care and better health outcomes for this group. Consequently, there is a need to identify the role of the primary care nurse in dementia care provision, nurse perceptions of this role and to also understand the barriers and enablers that may influence any current or potential primary care nurse role in dementia care provision.

Methods
Eight focus groups were conducted with a total of 36 primary care nurses. Data was transcribed verbatim and thematically analysed.

Results
There was a high level of agreement between primary care nurses that they had a role in provision of dementia care. This role was largely attributed to the strong therapeutic relationship between nurses and patients. However, dementia care provision was not without its challenges, including a perceived lack of knowledge, limited resources and the hierarchical nature of general practice. Three main themes were identified: personal attributes of the primary care nurse; professional attributes of the primary care nurse role and the context of practice. Six sub-themes were identified: knowing the person; overcoming stigma; providing holistic care; knowing what to do; team culture and working in the system.

Conclusions
The findings of this study suggest primary care nurses have a role in dementia care provision and, there is a need to provide support for the nurse to deliver person-centred health care in the context of cognitive impairment. As the demand for good quality primary care for people living with dementia increases, the role of the primary care nurse should be considered in primary care policy discussions. The knowledge gained from this study could be useful in informing dementia training content, to provide better prompts in the health assessment and care planning templates used by primary care nurses to better identify the care needs of people with a cognitive impairment and to develop dementia care guidelines for primary care nurses.