bluuebunny/crossref_metadata_2025_split huggingface dataset:
XIV Congresso de Iniciação Cientifica da Universidade de Araraquara
Authors: Carvalho De Lorenzo Helena 
Published: February 2021

Os trabalhos que compõem o presente volume da Revista Brasileira Multidisciplinar ReBRAm são versões expandidas de dez resumos, selecionados dentre os quase 500 trabalhos apresentados no XIV Congresso de Iniciação Cientifica da Uniara, realizado no período de 04 a 08 de novembro de 2019, na Universidade de Araraquara. Este evento, que se iniciou em 2006, como um pequeno congresso de caráter local, vem gradativamente se ampliando e ganhando a participação de estudantes e pesquisadores de outras instituições de ensino da região e acontece graças aos esforços de um grupo de professores que, em anos consecutivos, veem se empenhando para a realização do mesmo. Também tem sido o resultado de trabalho de nossa comunidade de docentes e pesquisadores, e da sua crença de que a iniciação cientifica é uma ferramenta fundamental para a formação profissional de nossos alunos.
É, evidentemente, impossível socializar com os leitores o calor gratificante de um congresso de iniciação cientifica, o interesse e alegria dos jovens e o intercambio fecundo entre estudantes e docentes de diversos cursos de graduação. Pensamos, porém, que é relevante partilhar com o público, em especial, leitores desta revista multidisciplinar, os artigos que compõem este volume, como prestação de contas de nosso trabalho, e como contribuição ao debate e à realização de novas pesquisas....
Metode Deteksi Intrusi Menggunakan Algoritme Extreme Learning Machine dengan Correlation-based Feature Selection
Authors: Sulandri Sulandri , Basuki Achmad , Bachtiar Fitra Abdurrachman 
Published: February 2021

<p>Deteksi intrusi pada jaringan komputer merupakan kegiatan yang sangat penting dilakukan untuk menjaga keamanan data dan informasi. Deteksi intrusi merupakan proses monitor <em>tra</em><em>f</em><em>fi</em><em>c</em> pada sebuah jaringan untuk mendeteksi adanya pola data yang dianggap mencurigakan, yang memungkinkan terjadinya serangan jaringan. Penelitian ini melakukan analisis pada <em>traffic</em> jaringan untuk mengetahui apakah paket tersebut mengandung intrusi atau merupakan paket normal. Data <em>traffic </em>yang digunakan untuk deteksi intrusi pada penelitian ini diambil dari <em>dataset</em> KDD Cup. Metode yang digunakan untuk melakukan deteksi intrusi dengan cara klasifikasi yaitu dengan menggunakan metode <em>Extreme Learning Machine</em> (ELM). Namun, dengan menggunakan metode ELM saja tidak mampu untuk menghasilkan akurasi yang baik maka, pada metode ELM perlu ditambahkan metode seleksi fitur <em>Correlation-Based Feature Selection</em> (CFS) untuk meningkatkan hasil akurasi dan waktu komputasi. Hasil penelitian yang dilakukan dengan menggunakan metode ELM menunjukkan tingkat akurasi mencapai 81,97% dengan waktu komputasi 3,39 detik. Setelah ditambahkan metode seleksi fitur CFS pada ELM tingkat akurasi meningkat secara signifikan menjadi 98,00% dengan waktu komputasi 2,32 detik.</p><p> </p><p><em><strong>Abstract</strong></em></p><p><em>Intrusion detection of computer networks is a very important activity carried out to maintain data and information security. Intrusion detection is the process of monitoring traffic on a network to detect any data patterns that are considered suspicious, which allows network attacks. This research analyzes the network traffic to find out whether the packet contains intrusion or is a normal packet. Traffic data used for intrusion detection in this study were taken from the KDD Cup dataset. The method used to do intrusion detection by classification is using the Extreme Learning Machine (ELM) method. However, using the ELM method alone is not able to produce good accuracy, so the ELM method needs to be added to the Correlation-Based Feature Selection (CFS) feature selection method to improve the accuracy and computational time. The results of the research conducted using the ELM method showed an accuracy rate of 81.97% with a computation time of 3.39 seconds. After adding the CFS feature selection method to ELM the accuracy level increased significantly to 98.00% with a computing time of 2.32 seconds.</em><em></em></p>
Desain Arsitektur IoT untuk Budidaya Gurami
Authors: Sudianto Yupit 
Published: February 2021

<p class="Abstrak">Sektor perikanan di Indonesia memiliki potensi bagus untuk dikembangkan. Dengan pengelolaan yang baik, sektor ini dapat memberikan kontribusi bagi ketahanan pangan nasional dan meningkatkan kesejahteraan bagi masyarakat Indonesia. Salah satu sektor perikanan yang menarik untuk dibudidayakan adalah ikan gurami. Gurami banyak diminati oleh masyarakat dan memiliki harga jual yang stabil. Namun, kendala dalam budidaya gurami adalah pertumbuhan yang lambat, biaya pakan yang tinggi, dan tingkat kelangsungan hidup yang rendah. Seiring dengan perkembangan teknologi <em>internet of things</em> (IoT) dewasa ini, tentunya teknologi ini dapat memberikan solusi bagi pembudidaya gurami untuk mengatasi kendala tersebut. Oleh karena itu, pada penelitian ini diusulkan arsitektur IoT untuk budidaya gurami. Arsitektur IoT yang diusulkan dalam penelitian ini memiliki enam desain yang terdiri dari <em>domain model</em>, <em>business process hierarchy</em>, <em>IoT layer</em>, <em>deployment</em>, <em>information</em>, dan <em>interoperability endpoint</em>. Dengan adanya arsitektur IoT ini diharapkan sistem IoT yang dibangun sesuai dengan kebutuhan pembudidaya gurami serta memudahkan <em>developers</em> untuk membangun dan mengembangkan sistem tersebut.</p><p class="Abstrak"> </p><p class="Abstrak"><strong><em>Abstract</em></strong></p><p class="Abstrak"><em>The fisheries sector in Indonesia has great potential to be developed. With good management, this sector can contribute to national food security and improve welfare for the people of Indonesia. One of the interesting fisheries sector to be cultivated is gurami. Gurami is much in demand by the public and has a stable selling price. However, growth in gouramy cultivation is slow growth, high food costs, and low survival rates. The development of internet of things (IoT) technology today, this technology can provide solutions for gouramy farmers to overcome these obstacles. Therefore, this research proposes IoT architecture for gouramy cultivation. The IoT architecture proposed in this study has six designs consisting of the domain model, business process hierarchy, IoT layer, deployment, information, and interoperability endpoints. The IoT architecture is expected to build the IoT system in accordance with the needs of gouramy farmers and make it easier for developers to build and develop the system.</em></p>
Medical genetic study of the Republic of North Ossetia Alania. II. Nosological spectrum of hereditary pathology in three districts
Authors: Гетоева З.К. , Кадышев В.В. , Джаджиева М.Ю. , Галкина В.А. , Перепелов А.В. , Михайлова Л.К. , Тебиева И.С. , Гинтер Е.К. , Зинченко Р.А. 
Published: February 2021

Представлен нозологический спектр моногенных наследственных болезней (МНБ) в трех районах Республики Северная Осетия Алания (РСОА) - Правобережном, Ардонском и Кировском, общей численностью 119 590 человек. Обследовано все население районов по протоколу генетико-эпидемиологических исследований (разработка ФГБНУ «МГНЦ»), выявлено и диагностировано 600 пациентов (из 418 семей) с различными МНБ. Всего выявлено 135 нозологических форм - 65 с аутосомно-доминантным типом наследования (АД), 57 с аутосомно-рецессивным (АР) и 14 с Х-сцепленным (Х-сц.). Определены распространенность заболеваний, частые и редкие нозологические формы. Проведено сравнение нозологического спектра и распространенности отдельных МНБ с таковыми в ранее обследованных популяциях европейской части России. Выявлены особенности разнообразия МНБ. Более высокие значения распространенности, чем в других популяциях РФ выявлены синдром Элерса-Данло, миотоническая дистрофия, несиндромальная умственная отсталость с различными типами наследования, различные формы пигментного ретинита и др. Ряд заболеваний, частых в обследованных регионах РФ, наоборот, встречались реже - вульгарный ихтиоз, нейрофиброматоз, наследственная моторно-сенсорная нейропатия и ихтиозиформная эритродеремия.
In this article we present the nosological spectrum of monogenic hereditary diseases (MHD) in three districts of the Republic of North Ossetia - Alania (RNOA) - Pravoberezhny, Ardonsky and Kirovsky, with a total population of 119,590 people. The entire population of the districts was examined according to the Protocol of genetic and epidemiological studies (developed by the Federal state budgetary Research Centre for Medical Genetics), 600 patients (from 418 families) with various NBS were identified and diagnosed. We identified 136 nosological forms of MHD - 65 with autosomal dominant type of inheritance (AD), 57 with autosomal recessive (AR) and 14 with X-linked (X-lin.). We determine the prevalence of diseases, frequent and rare nosological forms. The nosological spectrum and prevalence of individual MHD were compared with previously surveyed populations in the European part of Russia: Kirov, Kostroma, Arkhangelsk, Tver, Bryansk, Rostov regions, Krasnodar territory and the Republics of Karachay-Cherkessia, Adygea, Tatarstan, Bashkortostan, Mari El, Udmurtia and Chuvashia. Features of the MHD diversity are revealed. With higher prevalence values than in other populations of the Russian Federation, Ehlers-Danlo syndrome, myotonic dystrophy, non - syndromic mental retardation with various types of inheritance and various forms of retinitis pigmentosa, etc. A number of diseases that are frequent in the Russian Federation have shown on the contrary lower prevalence values - vulgar ichthyosis, neurofibromatosis, hereditary motor-sensory neuropathy and ichthyosiform erythroderemia.
Reduction of serotonin receptor 2A protein level in peripheral blood lymphocytes during antipsychotic medication is biomarker of therapy safety
Authors: Заботина А.М. , Грунина М.Н. , Волкова Е.В. , Насырова Р.Ф. , Тараскина А.Е. 
Published: February 2021

В лимфоцитах периферической крови (ЛПК) в группе пациентов с коморбидным течением шизофрении с синдромом алкогольной зависимости показаны более низкие значения количества белка рецептора 5-НТ2А и уровня его мРНК по сравнению с группой с неотягощенной психической патологией (р<0.001). Безопасная фармакотерапия ассоциирована со снижением количества рецептора 5-НТ2А в ЛПК на 28-й день без изменения уровня транскрипции гена, возможно вызванного интернализацией рецептора.
We studied mRNA and protein levels of serotonin receptor 2A (5-НТ2А) in lymphocytes of schizophrenia patients both before and after 28 days of antipsychotic therapy in order to estimate biomarkers of efficacy and safety of the treatment. We found lower mRNA and protein levels of 5-НТ2А in peripheral blood lymphocytes (PBL) of schizophrenia patients with alcohol addiction syndrome than in PBL of schizophrenia patients without addictions (р<0.001). Absence of common adverse side effects (antipsychotic-induced weight gain, parkinsonism, akathisia) during antipsychotic therapy was associated with reduction of 5-НТ2А protein level in PBL by 28th day of the treatment, while HTR2A mRNA level was not changed. Reduction of 5-НТ2А protein level in PBL by 28th day may be a potential biomarker of the antipsychotic therapy safety.
Ethical challenges of preimplantation genetic testing
Authors: Гребенщикова Е.Г. 
Published: February 2021

Рассматриваются основные этические вызовы предимплантационного генетического тестирования (ПГТ), раскрывается взаимосвязь этической проблематики экстракорпорального оплодотворения и ПГТ, анализируются социальные аспекты применения ПГТ.
The main ethical challenges of preimplantation genetic testing (PGT) are examined, the relationship between the ethical issues of IVF and PGT is revealed, the social aspects of the use of PGT are analyzed.
Ethical and legal problems of commodification of biomaterials in the development of genomics and genomic medicine
Authors: Попова О.В. 
Published: February 2021

В статье рассмотрен ряд этико-правовых проблем коммодификации биоматериалов в процессе развития геномики и геномной медицины. Показано, что биоматериалы в современном мире рассматриваются как объекты имущественного и патентного права и становятся источником получения прибыли. Зачастую это приводит к появлению казусов, связанных с защитой прав индивида, являющегося источником происхождения биоматериалов. Выдвинут тезис о том, что ситуация, связанная с оборотом биоматериалов, отражается в различных модусах отношений между индивидом, наукой и обществом, с характерной для каждого из них артикуляцией приоритета личного или общественного блага.
The article considers a number of ethical and legal problems of commodification of biomaterials in the development of genomics and genomic medicine. It is shown that biomaterials in the modern world are considered as objects of property and patent law and become a source of profit. Often this leads to the appearance of incidents related to the protection of the rights of the individual, which is the source of origin of biomaterials. The thesis is put forward that the situation associated with the circulation of biomaterials is reflected in various modes of relations between the individual, science and society, with the articulation of the priority of a personal or public good characteristic of each of them.
Sociological aspects of genetic carrier screening for autosomal recessive disorders
Authors: Ревазян К.З. , Мешков А.Н. , Ершова А.И. , Глечян А.М. , Сивакова О.В. , Войнова Н.А. , Волков А.К. , Драпкина О.М. 
Published: February 2021

Генетический скрининг на носительство вариантов, вызывающих развитие аутосомно-рецессивных заболеваний является важным звеном профилактики наследственных заболеваний на этапе планирования семьи. Пациентам поликлиники НОМТЦ МГТУ им. Н.Э. Баумана в возрасте 18-49 лет (женщины) и от 18 лет (мужчины) было предложено ознакомиться с брошюрой о генетическом скрининге на носительство вариантов, вызывающих развитие аутосомно-рецессивных заболеваний и заполнить анонимный опросник для выявления отношения к скринингу. Анкетирование продемонстрировало положительное отношение участников к проведению генетического скрининга, так как 73% опрошенных изъявили желание пройти скрининг, но у 46% были опасения касательно его возможных негативных последствий. При дальнейшем внедрении генетического скрининга на носительство вариантов, вызывающих развитие аутосомно-рецессивных заболеваний, в систему здравоохранения важно организовать просветительскую работу, информирующую население о роли скрининга и для устранения нежелательных последствий.
Genetic carrier screening for autosomal-recessive disorders is an important part of hereditary diseases prevention at the stage of family planning. Patients of the Bauman clinic (18-49 years old women and men older 18 years) were asked to read a brochure about carrier screening for autosomal-recessive disorders and fill out an anonymous questionnaire to identify their attitudes towards screening. The questionnaire showed a positive attitude of the participants towards genetic screening, as 73% of respondents expressed a desire to undergo screening, but 46% had concerns about its possible negative consequences. With the further implementation of carrier screening by the healthcare system, it is important to organize educational work that will inform the population about the role of screening and for eliminating undesirable consequences.
Genetic factors of predisposition to hereditary forms of thrombophilia in women with high-risk pregnancy
Authors: Ратникова С.Ю. , Жукова Т.П. , Зайцева Е.С. , Конева Т.Г. 
Published: February 2021

В настоящее время огромное значение имеет оценка генетических факторов, приводящих к риску тромбоэмболических осложнений у беременных женщин. Проведено исследование полиморфизма генов системы гемостаза (F5 (G1691А), F2 (G20210A), SERPINC1(G786A), PROC(A2583T)) методом полимеразной цепной реакции в режиме реального времени у 63 пациенток с отягощенным акушерским анамнезом. Показано, что присутствие в генотипе у 48 пациенток (76%) одного или сочетания нескольких низкофункциональных аллелей исследуемых генов является фактором риска развития тромбофилических осложнений беременности (фетоплацентарной недостаточности, угрозы прерывания, преэклампсии, преждевременной отслойки нормально расположенной плаценты, антенатальной гибели плода).
Estimation of genetic factors that lead to risk of thromboembolic complications in pregnant women, has a great importance in current time. Investigation of gene polymorphisms of hemostatic system (F5 (G1691А), F2 (G20210A), SERPINC1(G786A), PROC(A2583T)) with application of real time polymerase chain reaction in 63 patients with aggravated obstetric anamnesis was done. It was shown that the presence in the genotype of 48 patients (76%) of one or a combination of several low-functional alleles of the studied genes is a risk factor for the development of thrombophilic pregnancy complications (fetoplacental insufficiency, threatening miscarriage, preeclampsia, premature detachment of normally situated placenta, intrauterine fetal death).
Increased methylation of gene promoters in the trophoblast of spontaneous miscarriages with trisomy 16
Authors: Васильев С.А. , Толмачева Е.Н. , Васильева О.Ю. , Никитина Т.В. , Саженова Е.А. , Марков А.В. , Сердюкова Е.С. , Лебедев И.Н. 
Published: February 2021

Обнаружен повышенный уровень нарушений эпигенетической регуляции экспрессии генов в трофобласте хориона спонтанных абортусов с трисомией 16. Среди гиперметилированных генов была значимо обогащена группа генов секретируемых белков, значительное количество генов кодировали рецепторы и транскрипционные факторы. Гиперметилирование выявленных генов является потенциальной причиной гибели эмбрионов с трисомией 16 на ранних стадиях развития.
An increased level of abnormal epigenetic regulation of gene expression in the trophoblast of spontaneous miscarriages with trisomy 16 was found. Among the hypermethylated genes, the group of genes of secreted proteins was significantly enriched, and a significant number of genes encoded receptors and transcription factors. Hypermethylation of the identified genes is a potential cause of death of embryos with trisomy 16 in the early stages of development.
DNA-methylation analysis of differentially expressed genes in fibroblast cell-lines, derived from monozygotic twins discordant for Parkinson’s disease
Authors: Рыболовлев И.Н. , Власов И.Н. , Алиева А.Х. , Сломинский П.А. , Шадрина М.И. 
Published: February 2021

Болезнь Паркинсона (БП) является многофакторным гетерогенным нейродегенеративным заболеванием. Поскольку этиопатогенез БП недостаточно изучен, кроме поиска и анализа изменений на уровне ДНК, необходимо распространить фокус исследований на другие уровни: транскриптом и метилом. Изменения на уровне эпигенома можно исследовать у лиц с идентичной генетической конституцией, такой «моделью» являются дискордантные по этому заболеванию монозиготные близнецы. В исследовании приняло участие 3 пары фенотипически и генотипически монозиготных близнецов русского происхождения; В исследовании приняло участие 3 пары фенотипически и генотипически монозиготных близнецов русского происхождения. БП была уточнена у одного из каждой пары близнецов; длительность течения болезни у близнеца с БП составило по меньшей мере 7 лет.; длительность течения болезни у близнеца с БП составила по меньшей мере 7 лет. Были проанализированы метиломы крови и отобраны точки варьирующегося метилирования. Нами было найдено 8 дифференциально экспрессирующихся генов, которые могут быть дифференциально метилированы. Были выявлены различия между здоровым близнецом и близнецом с БП по уровню метилирования ДНК для ряда этих генов в клеточных линиях фибробластов. Полученные нами данные могут указывать на участие процесса ДНК-метилирования в регуляции транскрипции кандидатных генов-участников патогенеза БП.
In recent years it has been convincingly demonstrated that genetic factors play an important role in progression of Parkinson’s disease (PD). Since the etiology of PD has not been elucidated completely yet, it is crucial to shift focus of the research to the broader areas - to dive into investigations of methylome and transcriptome. Epigenetic regulation of gene expression may take part in pathogenesis of PD. Changes in epigenome can be conveniently investigated in case of individuals with almost identical genetic makeup, and monozygotic twins discordant for PD may be such “model”. 3 pairs phenotypically and genotypically monozygous twins of Russian ancestry were enrolled in the study. PD was diagnosed in one of each pair. The disease duration was at least 7 years. Data on blood methylomes was analyzed. Points of variable methylation in blood methylomes were selected. With this approach, 8 differentially expressed genes were found that also may be differentially methylated. Changes in methylation level for some of this genes were found in monozygotic twins discordant for PD fibroblasts cell-lines between healthy and afflicted siblings. Acquired data might suggest participation of DNA-methylation in transcription regulation of PD pathogenesis-related candidate genes.
Circulating PCSK9 levels and conventional risk factors in CAD
Authors: Deepa P K  , Kedari G S R  , Resmi C R  
Published: February 2021

Coronary artery disease (CAD) is the chief cause of mortality and morbidity worldwide. The aim of this study was to compare the levels PCSK9 and conventional risk factors of CAD in CAD patients and age and sex-matched controls and also to evaluate the relationship of circulating PCSK9 levels with other conventional risk factors of coronary artery patients. Sixty two clinically proved CAD patients and sixty-two healthy; age and sex-matched subjects without CAD were selected for the study. Detailed clinical and other relevant data were recorded using proforma. Five ml of fasting venous blood was collected from all the subjects and used for the investigations of fasting plasma glucose (FPG), HBA1C, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol (Direct), Apo B and PCSK9. The outcomes of this study showed that levels of FPG, HbA1c, lipid parameters-total cholesterol, triglycerides, LDL-c, Apo B were significantly higher whereas HDL-c were significantly low in CAD patients compared to normal controls. Circulating PCSK9 level was significantly elevated, and its level was correlated with other risk parameters. This study found that circulating PCSK9 level was significantly high, and its level was correlated with other risk parameters.
Correlation between BMI and Oral Cancer: A Hospital-Based Case-Control Study
Authors: Arun Prakash Sharma  , Seema Monga  , Junaid Malik  , Khaja Nasereruddin  , Shahid Rasool  , Ratna Priya  
Published: February 2021

Increased body mass index (BMI) is considered a significant factor in several malignancies of body. It also affects the prognosis of the management of malignancies. Its role in cancer of the oral cavity should also be evaluated as another risk factor other than tobacco, alcohol, virus etc. Therefore this study was conducted to evaluate the correlation between BMI and cancer of the oral cavity. A total of 160 patients (140 males, 20 females) with confirmed histopathologic diagnosis of oral squamous cell carcinoma (OSCC) and 200 healthy controls were enrolled. Height and weight of each study subject were measured. BMI was calculated by dividing the weight of the subject in kilograms with the square of the height in the square of metres. Chi-square test was used for evaluation of the level of significance. The number of those subjects with OSCC belonging to the overweight and obese group was 136 while the number of those healthy controls belonging to the overweight and obese group was 24. The statistical analysis revealed a significant correlation between BMI and oral cancer. There is a significant correlation between oral cancer and increased BMI. Increased BMI can also be considered as another critical risk factor for oral cancer because it has been found associated with other cancers of the oral cavity.