bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidimensional Analyses of the Learning Curve of Endoscopic Thyroidectomy
Authors: Liang Tsung‐Jung , Tsai Chung‐Yu , Liu Shiuh‐Inn , Chen I‐Shu 
Published: January 2021

AbstractBackgroundEndoscopic thyroidectomy has comparable surgical outcomes and superior cosmetic satisfaction to open thyroidectomy. However, steep learning curve is a concern. This study evaluated the learning curve of endoscopic thyroidectomy using various parameters and statistical methods.MethodsA total of 90 consecutive patients who underwent endoscopic thyroidectomy using bilateral axillo‐breast approach (BABA) between March 2016 and April 2020 were enrolled. Operative time, postoperative drainage amount, and blood loss were assessed by cumulative sum (CUSUM) analysis and moving average to evaluate the learning curve.ResultsUsing the CUSUM analysis, the peak point of both operative time and drainage amount occurred at the 30th case. No clear single peak was identified in the CUSUM plot for blood loss. The moving average also showed significant reduction in operative time and drainage amount after, approximately, the first 30 cases. The blood loss decreased after the 25th case. We therefore divided the patients into 2 phases: phase 1 (1–30 cases) and phase 2 (31–90 cases). The operative time, drainage amount, and blood loss decreased significantly in the phase 2 compared with phase 1. Lower pain score in first postoperative day and shorter hospital stay were also observed in the phase 2. Although the reduction in transient hypoparathyroidism did not reach statistical significance, no permanent hypoparathyroidism was noted in the phase 2.ConclusionsThe learning curve for endoscopic thyroidectomy is approximately 30 cases. Aside from the operative time, drainage amount may also serve as a surrogate for the learning curve evaluation.
ICD therapy in the elderly: a retrospective single-center analysis of mortality
Authors: Scheurlen Cornelia , van den Bruck Jan , Wörmann Jonas , Plenge Tobias , Sultan Arian , Steven Daniel , Lüker Jakob 
Published: January 2021

Abstract
Background
Current implantable cardioverter-defibrillator (ICD) guidelines do not impose age limitations for ICD implantation (IMPL) and generator exchange (GE); however, patients (pts) should be expected to survive for 1 year. With higher age, comorbidity and mortality due to non-sudden cardiac death increase. Thus, the benefit of ICD therapy in elderly pts remains unclear. Mortality after ICD IMPL or GE in pts ≥ 75 years was assessed.

Methods
Consecutive pts aged ≥ 75 years with ICD IMPL or GE at the University Hospital Cologne, Germany, between 01/2013 and 12/2017 were included in this retrospective analysis.

Results
Of 418 pts, 82 (20%) fulfilled the inclusion criteria; in 70 (55 = IMPL, 79%, 15 = GE, 21%) follow-up (FU) was available. The median FU was 3.1 years. During FU, 40 pts (57%) died (29/55 [53%] IMPL; 11/15 [73%] GE). Mean survival after surgery was 561 ± 462 days. The 1‑year mortality rate was 19/70 (27%) overall, 9/52 (17%) in pts ≥ 75 and 10/18 (56%) in pts ≥ 80 years. Deceased pts were more likely to suffer from chronic renal failure (85% vs. 53%, p = 0.004) and peripheral artery disease (18% vs. 0%, p = 0.02). During FU, seven pts experienced ICD shocks (four appropriate, three inappropriate). In primary prevention (n = 35) mortality was 46% and four pts experienced ICD therapies (two adequate); in secondary prevention (n = 35) mortality was 69% (p = 0.053) with three ICD therapies (two adequate).

Conclusion
Mortality in ICD pts aged ≥ 80 years was 56% at 1 and 72% at 2 years in this retrospective analysis. The decision to implant an ICD in elderly pts should be made carefully and individually.
Unicondylar knee replacement versus total knee replacement for the treatment of medial knee osteoarthritis: a systematic review and meta-analysis
Authors: Deng Meichao , Hu Yang , Zhang Zhongzu , Zhang Hongjun , Qu Yiming , Shao Gaohai 
Published: January 2021

Abstract
Background
Since the optimal surgery for isolated medial knee osteoarthritis (OA) is unclear, this study aimed at comparing the effectiveness of unicondylar knee replacement (UKR) with total knee replacement (TKR) for simple medial knee OA.

Methods
Literature searches of PubMed, Embase, Web of Science, and the Cochrane Library were searched up to 1th April 2020. Only studies comparing UKR with TKR for isolated medial knee OA were included. Data collection and extraction, quality assessment, and data analyses were performed according to the Cochrane standards.

Results
A total of 13 articles with 1888 patients were included, among which, 944 and 944 underwent UKR and TKR, respectively. The analyzed postoperative outcomes were mostly within 5 years of follow-up. The meta-analysis showed that UKR improved knee general function (P < 0.00001) and health (P = 0.02), moreover, reduced post-operative pain (P = 0.01) and complications (P < 0.05) more than TKR. There were no significant differences in postoperative revision (P = 0.252), high-activity arthroplasty score (HAAS) (P = 0.307) and Oxford knee score (OKS) (P = 0.15) between the two techniques.

Conclusions
The patients of UKR could achieve better clinical results than that of TKR, moreover, there were negligible differences between the two techniques in postoperative revision in the early and mid-term follow-up and surgeons should be aware of the important reasons for revision of UKR. Thus, UKR instead of TKR should be performed in patients with late-stage isolated medial knee OA.
Spatiotemporal Changes in the Gene Expression Spectrum of the β2 Adrenergic Receptor Signaling Pathway in the Lungs of Rhesus Monkeys
Authors: Zheng Zhongmei , Cao Bangrong , Hu Yu , Xie Liang , Gu Ling , Shi Fang , Liu Hanmin 
Published: January 2021

Abstract
Objective
β2 adrenergic receptor (ADRB2) agonists mainly participate in regulation of airway function through the ADRB2-G protein-adenylyl cyclase (AC) signaling pathway; however, the key genes associated with this pathway and the spatiotemporal changes in the expression spectrum of some of their subtypes remain unclear, resulting in an insufficient theoretical basis for formulating the dose and method of drug administration for neonates.

Methods
We performed sampling at different developmental time points in rhesus monkeys, including the embryo stage, neonatal stage, and adolescence. The MiSeq platform was used for sequencing of key genes and some of their subtypes in the ADRB2 signaling pathway in lung tissues, and target gene expression was normalized and calculated according to reads per kilobase million.

Results
At different lung-developmental stages, we observed expression of phenylethanolamine N-methyltransferase (PNMT), ADRB2, AC, AKAP and EPAC subtypes (except AC8, AKAP4/5), and various phosphodiesterase (PDE) subtypes (PDE3, PDE4, PDE7, and PDE8), with persistently high expression of AC6, PDE4B, and AKAP(1/2/8/9/12/13, and EZR) maintained throughout the lung-developmental process, PNMT, ADRB2, AC(4/6), PDE4B, and AKAP(1/2/8/9/12/13, EZR, and MAP2)were highly expressed at the neonatal stage.

Conclusion
During normal lung development in rhesus monkeys, key genes associated with ADRB2–G protein–AC signaling and some of their subtypes are almost all expressed at the neonatal stage, suggesting that this signaling pathway plays a role in this developmental stage. Additionally, AC6, PDE4B, and AKAP(1/2/8/9/12/13, and EZR) showed persistently high expression during the entire lung-developmental process, which provides a reference for the development and utilization of key gene subtypes in this pathway.
Physicochemical characteristics of surimi-like material made from the muscle tissues of freshwater mussels (Sinanodonta woodiana Lea, 1834)
Authors: Stangierski Jerzy , Rezler Ryszard , Grześ Bożena , Andrzejewski Wojciech , Konieczny Piotr 
Published: January 2021

AbstractThe aim of the study was to determine selected characteristics of surimi-like material (SLM) made from the muscle tissues of Sinanodonta woodiana (Lea, 1834) freshwater mussels. The research material consisted of unwashed mussel muscle homogenate as the control sample—C, mussel muscle tissue twice washed with water (SLM-W) and sample washed with NaCl at a concentration of 0.169 mol/L as well as water (SLM–S). A raw control sample and surimi like-materials were analysed using the SDS-PAGE technique. They were also tested using the DMTA method (dynamic mechanical thermal analysis) while heating the samples up to 80 °C and cooling to 20 °C. The thermal drip and texture of gels after heating (75 °C, 30 min) were also determined. The washing procedure had a significant impact on the protein composition of the SLMs. A significantly (p < 0.05) higher percentage of proteins with molecular weights of 270–273 kDa and 105–110 kDa (corresponding to specific filamin isoforms), as well as 42–43 kDa (corresponding to actin), were found in the SLMs compared to sample C. Ccorrelation analysis confirmed a strong positive relationship between the percentage share of the above proteins and the values of the elasticity modulus (r ≥ 0.84) and firmness (r ≥ 0.88) of SLM gels. The SLM-S sample was characterised by the lowest significant (p < 0.05) thermal drip values. During heating, the rheological traits of all samples changed at two stages: from 20 to 50 °C and over 50 °C. The highest dynamics of variation in the elasticity modulus (G′) value were noticed at temperatures exceeding 50 °C in all samples. The G′ values in the SLM samples were significantly greater than the values in sample C. The analysis revealed a strong correlation (r ≥ 0.81) between the determinants of the texture of the SLM samples and their rheological parameters. Sample SLM-W was the one with the highest firmness and elasticity values. The analysis showed that the textural properties of the SLM samples mainly resulted from the reaction of spatial matrices to mechanical interactions.
Data models, representation and adequacy-for-purpose
Authors: Bokulich Alisa , Parker Wendy 
Published: January 2021

AbstractWe critically engage two traditional views of scientific data and outline a novel philosophical view that we call thepragmatic-representational (PR) view of data. On the PR view, data are representations that are the product of a process of inquiry, and they should be evaluated in terms of their adequacy or fitness for particular purposes. Some important implications of the PR view for data assessment, related to misrepresentation, context-sensitivity, and complementary use, are highlighted. The PR view provides insight into the common but little-discussed practices of iteratively reusing and repurposing data, which result in many datasets’ having a phylogeny—an origin and complex evolutionary history—that is relevant to their evaluation and future use. We relate these insights to the open-data and data-rescue movements, and highlight several future avenues of research that build on the PR view of data.
Are there similarities between the Corona and the climate crisis?
Authors: Schmidt Robert C. 
Published: January 2021

AbstractIn this short paper, I look back at the early stages of the Corona crisis, around early February 2020, and compare the situation with the climate crisis. Although these two problems unfold on a completely different timescale (weeks in the case of Corona, decades in the case of climate change), I find some rather striking similarities between these two problems, related with issues such as uncertainty, free-rider incentives, and disincentives of politicians to adequately address the respective issue with early, farsighted and possibly harsh policy measures. I then argue that for complex problems with certain characteristics, it may be necessary to establish novel political decision procedures that sidestep the normal, day-to-day political proceedings. These would be procedures that actively involve experts, and lower the involvement of political parties as far as possible to minimize the decision-makers’ disincentives.
Electrical and thermal transport behaviours of high-entropy perovskite thermoelectric oxides
Authors: Zheng Yunpeng , Zou Mingchu , Zhang Wenyu , Yi Di , Lan Jinle , Nan Ce-Wen , Lin Yuan-Hua 
Published: January 2021

AbstractOxide-based ceramics could be promising thermoelectric materials because of their thermal and chemical stability at high temperature. However, their mediocre electrical conductivity or high thermal conductivity is still a challenge for the use in commercial devices. Here, we report significantly suppressed thermal conductivity in SrTiO3-based thermoelectric ceramics via high-entropy strategy for the first time, and optimized electrical conductivity by defect engineering. In high-entropy (Ca0.2Sr0.2Ba0.2Pb0.2La0.2)TiO3 bulks, the minimum thermal conductivity can be 1.17 W/(m·K) at 923 K, which should be ascribed to the large lattice distortion and the huge mass fluctuation effect. The power factor can reach about 295 μW/(m·K2) by inducing oxygen vacancies. Finally, the ZT value of 0.2 can be realized at 873 K in this bulk sample. This approach proposed a new concept of high entropy into thermoelectric oxides, which could be generalized for designing high-performance thermoelectric oxides with low thermal conductivity.
Berufsbezogene Zufriedenheit und Gesundheitswahrnehmung von Tanzpädagoginnen und -pädagogen
Authors: Schmidt Mike , Ohlendorf Daniela , Reer Rüdiger , Groneberg David A. , Wanke Eileen M. 
Published: January 2021

ZusammenfassungHintergrundDer eigene Körper ist das zentrale Arbeitsinstrument eines*einer Tanzpädagog*in (TP) innerhalb der Bewegungsvermittlung. Bisher fehlen Erkenntnisse über die subjektive Wahrnehmung der eigenen berufsassoziierten Gesundheit und Zufriedenheit sowie die Identifizierung gesundheitsbelastender Berufsmerkmale.MethodikIm Rahmen einer fragebogenbasierten Querschnittserhebung wurde eine Kohorte von TP in Deutschland zur eigenen Gesundheit und generellen Berufszufriedenheit und belastenden Aspekten im Zusammenhang mit ihrer Berufsausübung untersucht. Zusätzlich wurden allgemeine anthropometrische und soziodemographische Merkmale erfasst. Neben der Betrachtung der Gesamtkohorte wurde auf geschlechtsspezifische Unterschiede getestet. In die statistische Analyse wurdenn = 232 TP (m: 51/w: 181) im Alter von 43,1 ± 11,0 Jahren eingeschlossen.ErgebnisseDer allgemeine Gesundheitszustand wurde von 85,3 % der Befragten mit „befriedigend“ (26,1 %) bis „sehr gut“ (14,7 %) beurteilt. 59,2 % der Tanzpädagog*innen schätzten ihre Gesundheit „gut“ (35,3 %) bis „sehr gut“ ein. Es herrschte eine hohe Zufriedenheit mit der eigenen Berufsausübung für 80 % der Teilnehmenden. Die TP fühlten sich überwiegend in der Lage (trifft „voll & ganz“ bzw. „eher zu“), mit den physischen (75,7 %) und psychischen Berufsanforderungen (70,3 %) umzugehen. Als belastende Berufsmerkmale in der Eigenwahrnehmung können neben Zukunftsängsten (51,5 %) vor allem arbeitsorganisatorische (fehlende Zeit für Familie und Freunde bei 28,4 %) und ökonomische Aspekte (Einkommensunsicherheit bei 61,0 % und fehlende Altersabsicherung bei 65,7 %) herausgestellt werden.DiskussionDie Berufsausübung als TP geht mit einer hohen generellen Zufriedenheit und einem positiven Empfinden des eigenen Gesundheitszustandes einher. Eine Bestätigung dieser positiven Ergebnisse durch Verletzungs- und Erkrankungsstatistiken steht noch aus. Darüber hinaus wäre eine Verbesserung arbeitsorganisatorischer und ökonomischer Aspekte wünschenswert.
Surface-applied or incorporated biochar and compost combination improves soil fertility, Chinese cabbage and papaya biomass
Authors: Cox Justine , Hue Nguyen V. , Ahmad Amjad , Kobayashi Kent D. 
Published: January 2021

AbstractMany Hawaiian agricultural soils are acidic with low-nutrient retention; therefore, organic soil amendments are often used to improve soil properties and increase yields. Amendments can be incorporated for annual crops, but perennial orchards need surface application to avoid damaging surface roots. Pot trials compared responses to incorporated (IBC) or surface-applied (SBC) combination of hardwood biochar and chicken manure compost (4% v/v of each amendment) added to an Andisol and Oxisol. Soil pH was increased by 0.4–1.1 units in IBC and by 0.2–0.5 for SBC in the 0–10 cm soil layer. Both SBC and IBC increased soil total N, extractable P, Ca and Mg in the 0–10 cm soil layer. Soil pH, total C and extractable Ca were also higher in the 10–20 cm soil layer for IBC soil, indicating movement and/or leaching of amendments. Chinese cabbage biomass was 18–70% higher in the IBC and 14–47% higher in the SBC than that in the unamended soil, while papaya biomass was 23% and 19% higher in SBC and IBC, respectively. There was a greater response in the more acidic Andisol soil, with larger improvements in soil pH, plant nutrient uptake and root biomass than the Oxisol. Surface application was as effective in increasing plant growth as the incorporated amendment, providing evidence for farm scale assessment. Biochar and compost are recommended for use in tropical soils, and surface application may be beneficial to annual and perennial crops.
Contracting for Terroir in Sake
Authors: Ramseyer J. Mark 
Published: January 2021

Over the last century, Japanese consumers have steadily lost their taste for sake. Several large producers dominate the mass market through economies of scale, but the regional brewers have gradually gone out of business. In this environment, a small group of enterprising regional brewers began to create a market for premium sake with the environmental variations so important to French terroir.To produce this terroir sake, brewers must convince local farmers to grow high-risk and high-cost varieties of rice optimized for premium sake. The challenge involves unusually complex incentive and informational requirements. Yet the parties almost never draft elaborate contracts with verifiable terms, and rarely vertically integrate. Instead, they build dense and refined networks of social capital among themselves and combine short-term renewable (and hence terminable) contracts, extremely high (efficiency-wage level) prices, and close monitoring by the brewer. In the process, they give the farmers strong incentives to let the brewers intervene as needed in the farming.The brewers and farmers neither draft elaborate contracts nor vertically integrate for a simple reason: they do not need to do so. The combination of dense networks of social capital, terminable short-term contracts, and high prices gives them all the flexibility they need.
Born Again Black Panther: Race, Christian Conservatism, and the Remaking of Eldridge Cleaver
Authors: Wells Dan 
Published: January 2021

ABSTRACTWhen Eldridge Cleaver, the former Black Panther Party Minister of Information, returned to the United States in November 1975, he claimed to have surrendered his life to Christ and conservatism. Utilizing the Eldridge Cleaver Papers housed at the Bancroft Library, this article recounts the transformation of Eldridge Cleaver from radical Black Panther to born-again Christian and anticommunist crusader. Cleaver's story of transformation demonstrates the pervasive power of the twentieth-century crusade against communism and the manner in which American conservatism created distinct categories of race that were written on the mind, body, religious belief, and practice of Eldridge Cleaver. This article highlights how conservatives enacted a program of racial respectability, remaking Eldridge in the image of conservative, capitalist, Christian whiteness. Cleaver was stripped of his “blackness,” a conservative effort to distance him from the “volatile black figures” of the mid-twentieth century. If Cleaver held on to any vestige of his old life—his leather jacket, “regional euphemisms,” liberationist ideology, and even his Afro hairstyle—his new life would be useless to conservatives. This article illustrates how Cleaver participated in a global crusade that sought to maintain and extend the unifying commitments of twentieth-century religious conservatism. Those commitments included (1) the commercial, economic, and political interests that produced, funded, and policed conservatism; (2) traditional white, middle-class family values; and (3) political, racial, gendered, and religious understandings of the citizen subject. Eldridge Cleaver and his anticommunist crusade are windows into the distinct categories of religion, politics, and race—Christianity, conservatism, and white respectability—constructed and enacted by American conservatives in the twentieth century.
Predictive capacity and cut-off points of adiposity indices for body fat prediction according to adolescent periods
Authors: Morais Núbia de Souza de , Miranda Valter Paulo Neves , Ribeiro Sarah Aparecida Vieira , Pereira Patrícia Feliciano , de Souza Eliana Carla Gomes , Franceschini Sylvia do Carmo Castro , Priore Silvia Eloiza 
Published: January 2021

AbstractOverweight is increasing in the adolescent population and became a public health problem in the world. This study aimed to identify the body adiposity indices (BAI) with the best capacity to predict excess fat tissue and propose cut-off points for them, according to sex and adolescence period. This is a cross-sectional study. We calculated BMI, conicity index (CI), BAI, body roundness index (BRI), waist:height ratio (WtHR) and waist:hip ratio. Predictive capacity and cut-off points of adiposity indices were established by ROC (receiver operating characteristic) curves. We determined AUC-ROC and CI, stratified by sex and adolescence period. The best index to identify excess body fat in 10-13-year-old female adolescents was the WtHR (AUC = 0·92), like the BAI in girls aged from 14 to 16 years old (AUC = 0·87) and 17 to 19 years old (AUC = 0·80). In male adolescents aged from 10 to 13 years old and 14 to 16 years old, the best index was the WtHR (AUC = 0·93 and AUC = 0·8, respectively), like the BAI in boys aged from 17 to 19 years old (AUC = 0·95). The use of indices with specific cut-off points for each period of adolescence and according to sex is important for the reliable diagnosis of excess body fat. It is advisable to use indices together to obtain a more accurate assessment. Thus, the WtHR and BAI are reproducible and reliable, with high sensitivity and specificity values, and can be used together with the BMI.
Consumption of flavonoid-rich fruits, flavonoids from fruits and stroke risk: a prospective cohort study
Authors: Gao Qi , Dong Jia-Yi , Cui Renzhe , Muraki Isao , Yamagishi Kazumasa , Sawada Norie , Iso Hiroyasu , Tsugane Shoichiro ,   for the Japan Public Health Center-based Prospective Study Group
Published: January 2021

AbstractWe sought to examine the prospective associations of specific fruit consumption, in particular flavonoid-rich fruit (FRF) consumption, with the risk of stroke and subtypes of stroke in a Japanese population. A study followed a total of 39 843 men and 47 334 women aged 44–76 years, and free of CVD, diabetes and cancer at baseline since 1995 and 1998 to the end of 2009 and 2012, respectively. Data on total and specific FRF consumption for each participant were obtained using a self-administrated FFQ. The hazard ratios (HR) of stroke in relation to total and specific FRF consumption were estimated through Cox proportional hazards regression models. During a median follow-up of 13·1 years, 4091 incident stroke cases (2557 cerebral infarctions and 1516 haemorrhagic strokes) were documented. After adjustment for age, BMI, study area, lifestyles, dietary factors and other risk factors, it was found that total FRF consumption was associated with a significantly lower risk of stroke in women (HR = 0·70; 95 % CI 0·58, 0·84), while the association in men was not significant (HR = 0·93; 95 % CI 0·79, 1·09). As for specific FRF, consumptions of citrus fruits, strawberries and grapes were found associated with a lower stroke risk in women. Higher consumptions of FRF, in particular citrus fruits, strawberries and grapes, were associated with a lower risk of developing stroke in Japanese women.