bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Aging-Related Genes on the Prognosis of Colon Cancer
Authors: Liu Yushu , Gong Jiantao , Huang Yanyi , Jiang Qunguang 
Published: November 2021

Abstract
Background:Colon cancer is a common malignant cancer with high incidence and poor prognosis. Cell senescence and apoptosis are important mechanisms of tumor occurrence and development, in which aging-related genes(ARGs) play an important role. This study aimed to establish a prognostic risk model based on ARGs for diagnosis and prognosis prediction of colon cancer .Methods: We downloaded transcriptome data and clinical information of colon cancer patients from the Cancer Genome Atlas(TCGA) database and the microarray dataset(GSE39582) from the Gene Expression Omnibus(GEO) database. Univariate COX, least absolute shrinkage and selection operator(LASSO) regression algorithm and multivariate COX regression analysis were used to construct a 6-ARG prognosis model and calculated the riskScore. The prognostic signatures is validated by internal validation cohort and external validation cohort(GSE39582).In addition, functional enrichment pathways and immune microenvironment of aging-related genes(ARGs) were also analyzed. We also analyzed the correlation between rsikScore and clinical features and constructed a nomogram based on riskScore. We are the first to construct prognostic nomogram based on ARGs.Results: Through univariate COX,LASSO regression algorithm and multivariate COX regression analysis,6 prognostic ARGs (PDPK1,RAD52,GSR,IL7,BDNF and SERPINE1) were screened out and riskScore was constructed. We have verified that riskScore has good prognostic value in both internal validation cohort and external validation cohort. Pathway enrichment and immunoanalysis of ARGs provide a direction for the treatment of colon cancer patients. We also found that riskScore was closely related to the clinical characteristics of patients. Based on riskScore and related clinical features, we constructed a nomogram, which has good predictive performance.Conclusion: The 6-ARG prognostic signature we constructed has a certain clinical predictive ability. Its riskScore is also closely related to clinical characteristics, and nomogram based on this has stronger predictive ability than a single indicator. ARGs and the nomogram we constructed may provide a promising treatment for colon cancer patients.
The in vitro antimicrobial and antioxidant activity of leaves of medicinal plants with phytobiotic potential in animal production
Authors: Aroche Roisbel , Jiang Xianren , Martínez Yordan , Rodríguez Román , Li Xilong , Arévalo Ana Carolina , Avellaneda Mavir Carolina 
Published: November 2021

Abstract
Little is known about which secondary metabolites are responsible for inhibiting pathogenic bacteria and reducing the pro-oxidant effect on the leaves of four medicinal plants used as phytobiotic in animal production. The aim of this study was to evaluate the antimicrobial and antioxidant activity of four medicinal plants (Anacardium occidentale, Psidium guajava, Morinda citrifolia and Moringa oleifera.) in vitro. A total of six bacterial strains were inoculated, then minimum bactericidal concentration (MBC) was evaluated in fine powder and minimum inhibitory concentration (MIC) and MBC were determined on the aqueous extract. Also, the in vitro antioxidant activity was evaluated through 1,1-diphenyl-2-picryl-hydrazyl, as well as the main secondary metabolites were identified and quantified by chromatographic analysis. The results showed that Anacardium occidentale and Psidium guajava leaves had higher antimicrobial activity against all bacterial strains. In addition, Morinda citrifolia inhibited S. aureus in the aqueous extract, although without in vitro bactericidal effect, while Moringa oleifera leaf did not show antimicrobial effect. All plants showed antioxidant capacity, standing out Anacardium occidentale and Psidium guajava. Mainly the leaves of Anacardium occidentale showed high concentrations of quercetin 3-O-glucoside-7-O-rhamnoside, kaempeferol-7-O-glucoside, quercetin, caffeic acid, and cinnamic acid. Apparently, the antimicrobial and antioxidant activity are due to the main polyphenolic compounds identified in medicinal plants (mainly Anacardium occidentale and Psidium guajava); however, further studies are necessary to elucidate the exact mechanism.
Central Nervous System Disorders Associated to Immune Checkpoint Inhibitors
Authors: de Souza Felipe Fanine , Trevisani Julia Petry , Breis Letícia Caroline , Sizenando Luís Gustavo Marcelino , Schlindwein Marco Antônio Machado , Silva Paola Herreira , da Cunha Ribas Gustavo , Gonçalves Marcus Vinicius Magno 
Published: November 2021

Abstract:
New therapies and alternatives for the containment of tumor progression are being proposed
for the treatment of cancer. In this context, monoclonal therapies using Immune Checkpoint
Inhibitors (ICI) come as a therapeutic proposal. They are responsible for immunological control by
blocking PD-1, PD-L1 and CTLA-4 molecules. However, among the effects caused by therapy, the
use of medications is associated with neurological diseases reported as an adverse effect, affecting
the Central Nervous System (CNS) and causing a wide range of symptoms. In this regard, the present
bibliographic review presents the main CNS disorders associated with this therapy, in addition
to the incidence, symptoms and treatment of these diseases.
Gisekia pharnaceoides Restores Colonic Mucosal Homeostasis by Regulating
Antioxidant Enzyme System and Cytokines Signaling in Ulcerative
Colitis Mice Model
Authors: Javaid Faraza , Aslam Naveed , Arshad Hafiza Maida , Awan Ambreen Mehmood , Majeed Wafa , Jabeen Qaiser 
Published: November 2021

Background:
Gisekia pharnaceoides Linn. (Aizoaceae), traditionally known as baluka saag or sareli is commonly found in the deep Cholistan region of Pakistan. It is used by native community for the mitigation of a range of diseases, including inflammatory disorders and gastric ulcers.

Objective:
This study is designed to evaluate the defensive impact of G. pharnaceoides in acetic acid-induced ulcerative colitis in mice and to discover the mechanism for anti-inflammatory action. Method: The ethanolic crude extract of G. pharnaceoides (Gp.Cr) was prepared and evaluated for phytochemical substances by preliminary screening and HPLC analysis. Anti-inflammatory activity of Gp.Cr (300 and 500 mg/kg) was examined by administration of 200 µl of 7.5% acetic acid intra-rectally to induce ulcerative colitis and colonic mucosal injury, while mucosal homeostasis was evaluated by disease activity index, colonic ulcer score and hematological parameters. Anti-inflammatory potential was quantified by assessing antioxidant enzymes (SOD, CAT, GPX-1), lipid peroxides, nitric oxide and cytokines (IL-1β, IL-6, TNF-α) immunoassays and further analyzed by histological analysis of colon tissues.

Results:
Phytochemical screening of Gp.Cr revealed the presence of alkaloids, phenols, flavonoids, steroids, tannins and saponins, while HPLC analysis confirmed the presence of quercetin, gallic acid, coumaric and sinapic acid. In acetic acid-induced ulcerative colitis model, Gp.Cr (300 and 500 mg/kg) along with sulphasalazine (500 mg/kg) decreased disease activity index, ulcer scores and hematological parameters. Gp.Cr showed a significant anti-inflammatory potential by increasing antioxidant enzymes and decreasing lipid peroxides, nitric oxide and cytokines levels. Histopathological examination showed significant decline in ulceration and tissue disruption.

Conclusion:
Hence, the findings confirmed the effectiveness of G. pharnaceoides crude extract in the treatment of ulcerative colitis and might be a promising remedy to manage inflammatory disorders.
Idarubicin and Ara-C Treatment Associated with Fungal Infection in Acute Leukemia Patients with Febrile Neutropenia
Authors: Wanitpongpun Chinadol , Teawtrakul Nattiya , Lanamtieng Theerin , Chansung Kanchana , Sirijeerachai Chittima , Amampai Worakamol , Sawanyawisuth Kittisak 
Published: November 2021

Background:
Pateints with acute leukemia along with febrile neutropenia is at risk for
fungal as well as bacterial infections. Fungal infection is a more serious and common infection in
this setting, leading to a high mortality rate. There is limited data on clinical factors predictive of
fungal infection in acute leukemia with febrile neutropenia.

Objective:
This study aimed to evaluate clinical predictive factors of fungal infection in acute
leukemia patients with FN.

Methods:
This was a retrospective analytical study and included adult patients diagnosed with
acute leukemia, who developed FN, and had positive culture with either bacterial or fungal infection.
Predictors for fungal infection were calculated by using logistic regression analysis. A subgroup
analysis in patients with acute myeloid leukemia (AML) was also performed.

Results:
There were 94 patients who met the study criteria. Of those, 29 patients had positive culture
for fungus (30.82%), categorized as Aspergillus (19 patients; 65.51%) and Candida (10 patients;
34.49%). The mortality rate was significantly higher in the fungal infection group than the
bacterial infection group (24.14% vs. 6.15%; p 0.031). There were six factors in the final model predictive
of fungal infection with one independent predictor: treatment regimen of Idarubicin plus
Ara-C with an adjusted odds ratio of 5.188 (95% CI of 1.386, 19.419). A subgroup analysis for fungal
infection in patients with AML showed that only the treatment regimen of Idarubicin plus Ara-
C was a significant factor. Its adjusted odds ratio was 5.138 (95% CI of 1.156, 24.467).

Conclusion:
Treatment with idarubicin and Ara-C may increase the risk of fungal infection in
acute leukemia patients with FN.
Nuevas formas de enfrentar la realidad
Authors: del Ángel Martínez Rosa María , Carranco Arenas Morgana 
Published: November 2021

Es indudable que los y las docentes instructores están constantemente buscando formas más efectivas e innovadoras de enseñar. En los últimos 18 meses, esta búsqueda se ha vuelto aún más acentuada, ya que la covid-19 sacudió el panorama universitario y escolar, y el mundo académico, lo que y empujó a los docentes a experimentar con nuevas estrategias para incentivar a sus estudiantes. Actualmente, si hacemos una breve búsqueda en internet, podemos encontrar varios métodos de enseñanza innovadores, desde el aula invertida, conferencias digitalizadas o en línea —como tareas previas a la clase—, comunidades de práctica e investigación, hasta dictar la sesión en un canal de YouTube o podcast.
La gestion d’un risque territorialisé en milieu urbain : exemple du dispositif ESPADA pour la gestion des crues rapides à Nîmes
Authors: Tchekemian Anthony , Boussageon Jeanne 
Published: November 2021

En la geografía, el estudio de los riesgos se orienta esencialmente hacia la articulación entre la predicción, la prevención y la comprensión del riesgo. Entonces, ¿cómo predecir, anticipar y alertar antes de que ocurra el evento? Y consecuentemente, ¿cómo intervenir antes de tener la certeza, es decir, antes de que se produzca el evento? Un ejemplo de riesgo territorializado, donde la relación entre la comprensión, predicción y prevención parece funcionar, es el riesgo de inundación. Seguido de una terrible inundación ocurrida en Nîmes en 1988, analizamos cómo, por una conciencia colectiva, fue implementado por el municipio y el cuerpo de bomberos de Gard, un dispositivo de alerta y seguridad, denominado ESPADA, con el fin de evitar que un desastre departamental vuelva a suceder.
Fashion in Postmodern Political Communication
Authors: Afanasieva Olga V. 
Published: November 2021

The goal of this article is to try to reach theoretical comprehension of the political fashion phenomenon. Conceptualization of fashion as an effect of mass communication allows one to see in it not only a phenomenon of pop culture but also an immanent side, and at the same time the main social, psychological and mental risk of the progress, – the accelerating humanity evolution. The article shows how modern values – novelty priority, truth accessibility, individualism, – and mass communications progress maximize the potential and danger of mass mental enthusiasm in political sphere. The author substantiates the following conclusion: political fashion in the communication mental context of postmodern appears to be the manifestation and factor the increasing crisis of social structure.
Pengaruh Literasi Keuangan dan Pengendalian Diri terhadap Perilaku Konsumtif Mahasiswa
Authors: Prihatini Diary , Irianto Agus 
Published: November 2021

This study aims to determine and analyze 1) the effect of financial literacy on the consumptive behavior of students of the Economics Faculty of Padang State University 2) the effect of self-control on the consumptive behavior of students of the Economics Faculty of Padang State University, and 3) the effect of financial literacy on self-control. This type of research is an inferential descriptive study. The sampling technique used in this study was proportional random sampling technique with a sample of 86 students. The data analysis technique used in this research is descriptive analysis and path analysis. The results showed that (1) financial literacy has a significant effect on the consumptive behavior of students of the Economics Faculty of Padang State University, (2) Self-control has a significant effect on the consumptive behavior of students in the Economics Faculty of Padang State University, and (3) Financial literacy has a significant effect on self-control of students in the Economics Faculty of State University field.Abstrak ditulis salam bahasa inggris, menggunakan jenis huruf Palatino Linotype 10 pt spasi satu, Max 200 kata.Keywords : financial literacy, self-control, consumptive behavior
Pengaruh Kecerdasan Emosional dan Komunikasi Interpersonal Terhadap Hasil Belajar Siswa pada Mata Pelajaran Pengelolaan Bisnis Ritel
Authors: Yusrida Hafizah , Kurniawati Tri 
Published: November 2021

This study aims to analyze: 1) the effect of emotional quotientand interpersonal communication on student learning outcomes, 2) the effect of emotional quotient on student learning outcomes,3) the effect of interpersonal communicationon student learning outcomes. This is a descriptive and associative research. The sampling technique used is total sampling, with 84 samples.The results show that (1) there is a positive and significant influence of emotional quotient and interpersonal communication on student learning outcomes, (2) there is a positive and significant influence of emotional quotient on student learning outcomes,(3) there is a positive and significant influence of interpersonal communication on student learning outcome.The teacher can always help students control emotions in the classroom and can teach how to communicate well between fellow students in the classroom, because with emotional intelligence and good interpersonal communication will improve student learning outcomes. Keywords: emotional quotient, interpersonal communication, student learning outcomes
Penerapan Metode Drill and Practice untuk Meningkatkan Pemahaman Guru Akuntansi SMK dalam Penyusunan Laporan Arus Kas
Authors: Sari Vita Fitria , Afriyenti Mayar 
Published: November 2021

The objective of this research is determine whether there is difference in the teacher's understanding of the material for preparing cash flow reports before and after receiving training treatment for preparing cash flow reports by applying the drill and practice method. This research categorized as pre-experimental (nondesign) by the method of the one group pretest – posttest design. Data analysis carried out using independent sample t-test. The results indicated that there is difference in the understanding of accounting teachers on the material for preparing cash flow statements before and after receiving treatment in the form of training in preparing cash flow reports by applying the drill and practice method. The application of drill and practice method can be recommended as an alternative learning method for accounting.
POWER GENERATOR FROM OCEAN WAVE ENERGY CONVERSION
Authors: Aribowo Widi , Agung Achmad Imam , Haryudo Subuh Isnur , Muarif Syamsul 
Published: November 2021

The need for electrical energy has increased every year. On the other hand, the largest power plants in Indonesia still use non-renewable energy sources such as coal and petroleum, while these non-renewable energy sources will eventually run out. To anticipate running out of this energy, a renewable energy source is needed. This existence will not run out even though it is consumed every day. Renewable energy that can be used for conversion into electrical energy in coastal areas is wave power. The waves that always crash on the shoreline can be used to drive turbines. The turbine rotates due to the crashing waves connected to a DC generator. It will convert mechanical energy into electrical energy. The electrical energy generated by the DC generator is used to charge the battery. The purpose of this research is the know-how to design a wave power generator and to determine the performance. The experimental method is used in this study. In the results, the generator works optimally during the day with the resulting voltage of 10.6 V to 10.7 V with rotation speed of 623 Rpm to With 710 Rpm.
MODEL E-BUSINESS MENGGUNAKAN PIECES FRAMEWORK UNTUK PENINGKATAN DAYA SAING UMKM BERBASIS MOBILE APPLICATION
Authors: Azizah Noor , Wahono Buang Budi 
Published: November 2021

Usaha Kecil dan Menengah (UKM) merupakan salah satu bidang yang memberikan kontribusi yang segnifikan dalam memacu pertumbuhan ekonomi Indonesia. Di sisi yang lain, perkembangan teknologi dan internet juga berkembang sangat cepat. Oleh karena itu, pengelolaan bisnis dengan memanfaatkan teknologi digital yang ada saat ini menjadi bagian penting dalam meningkatkan daya saing UMKM agar mampu berkompetisi dengan pelaku industri yang lain. Tujuan dari penelitian ini adalah membangun sebuah e-business yang digunakan untuk meningkatkan performa bisnisnya dalam rangka mencapai keunggulan kompetitifnya agar mampu berdaya saing dengan para kompetitor yang lain. Tools yang digunakan untuk menganalisa kebutuhan sistem menggunakan PIECES Framework yang meliputi performance, informations, economics, control, efficency, dan services. Adapun data primer diperoleh dari 50 responden untuk mengukur tingkat kepuasan penggunaan sistem e-business dalam pengelolaan bisnis UMKM. Hasilnya diperoleh rata-rata kepuasan pengguna, 3,92 yang artinya sistem e-business yang dikembangkan sangat penting dan pengguna merasa puas dalam penggunaan sistem tersebut
Design and realisation of residential property management information system based on browser/server mode
Authors: Ma Mingze 
Published: November 2021

Abstract
The data filling, mathematical calculations and statistical operations for property management are realised by a system development tool that adopts the browser/server (B/S) architecture, Java, as the development language and a framework that adopts Spring MVC mode; additionally, the MySQL database is used, the source code and database interaction process use the Mybatis framework and the front-end display uses the VUE.js framework.. Functional modules include the following elements: owner information, real estate information, engineering equipment, personnel management and lease management. The system has passed the functional test, if it has been in trial operation for 1 year in multiple residential communities and has the characteristics of simple operation, stable operation and strong scalability, among others.
Phototherapy in the Treatment of Diabetic Foot — A Preliminary Study
Authors: Mikołajczyk Zbigniew , Nowak Iwona , Kawiński Andrzej , Mik Michał 
Published: November 2021

Abstract
The first part of the publication presents a substantively insightful literature study on the essence and effects of light waves on wound healing in living organisms, including the use of phototherapy in the treatment of the diabetic foot. A knitted textile dressing was designed and manufactured for phototherapy of patients with diabetes suffering from diabetic foot syndrome (DFS). The proposed solution is intended for the treatment of dermal tissues within the patient's foot affected because of diabetic disease at an early stage. Thus, the use of a knitted dressing with incorporated fiber optic structures and powered by a semiconductor laser emitting a 405 nm light wave from its entire surface would prevent further anomalies of the patient's tissues and help to avoid surgical intervention.
Acute Kidney Injury Following Rhabdomyolysis in Critically Ill Patients
Authors: Saverymuthu Alvin , Teo Rufinah , Zain Jaafar Md , Cheah Saw Kian , Yusof Aliza Mohamad , Rahman Raha Abdul 
Published: November 2021

Abstract

Introduction
Rhabdomyolysis, which resulted from the rapid breakdown of damaged skeletal muscle, potentially leads to acute kidney injury.

Aim
To determine the incidence and associated risk of kidney injury following rhabdomyolysis in critically ill patients.

Methods
All critically ill patients admitted from January 2016 to December 2017 were screened. A creatinine kinase level of > 5 times the upper limit of normal (> 1000 U/L) was defined as rhabdomyolysis, and kidney injury was determined based on the Kidney Disease Improving Global Outcome (KDIGO) score. In addition, trauma, prolonged surgery, sepsis, antipsychotic drugs, hyperthermia were included as risk factors for kidney injury.

Results
Out of 1620 admissions, 149 (9.2%) were identified as having rhabdomyolysis and 54 (36.2%) developed kidney injury. Acute kidney injury, by and large, was related to rhabdomyolysis followed a prolonged surgery (18.7%), sepsis (50.0%) or trauma (31.5%). The reduction in the creatinine kinase levels following hydration treatment was statistically significant in the non- kidney injury group (Z= -3.948, p<0.05) compared to the kidney injury group (Z= -0.623, p=0.534). Significantly, odds of developing acute kidney injury were 1.040 (p<0.001) for mean BW >50kg, 1.372(p<0.001) for SOFA Score >2, 5.333 (p<0.001) for sepsis and the multivariate regression analysis showed that SOFA scores >2 (p<0.001), BW >50kg (p=0.016) and sepsis (p<0.05) were independent risk factors. The overall mortality due to rhabdomyolysis was 15.4% (23/149), with significantly higher incidences of mortality in the kidney injury group (35.2%) vs the non- kidney injury (3.5%) [ p<0.001].

Conclusions
One-third of rhabdomyolysis patients developed acute kidney injury with a significantly high mortality rate. Sepsis was a prominent cause of acute kidney injury. Both sepsis and a SOFA score >2 were significant independent risk factors.