bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment
Authors: Staszewski Cara , Herrera Kimberly M. , Kertowidjojo Elizabeth , Ly Victoria , Iovino Nicole , Garretto Diana , Kaplan Cynthia , Persad Malini D. , Garry David J. 
Published: October 2021

Introduction. To compare the effects of medication-assisted treatment on the placenta in pregnant women with opioid use disorder and uncomplicated pregnancies. Methods. This is a case-controlled study of pregnant women utilizing medication-assisted treatment, buprenorphine or methadone, which were matched to healthy uncomplicated controls by gestational age. Placental evaluations and neonatal outcomes were evaluated. Data analysis performed standard statistics and relative risk analysis with a

p
<
0.05

considered significant. Results. There were 143 women who met the inclusion criteria: 103 utilizing MAT, 41 buprenorphine and 62 methadone, and 40 uncomplicated matched healthy controls. The incidence of delayed villous maturation was 36% in the medication-assisted group compared with 10% in controls (RR 3.6: 95% CI 1.37-9.43;

p
<
0.01

). The placental weight was greater (

541
±
117

g versus

491
±
117

g;

p
=
0.02

), and the fetoplacental weight ratio was lower (

5.70
±
1.1

versus

7.13
±
1.4

;

p
<
0.01

) in the medication-exposed pregnancies compared with controls. The mean birth weight of the MAT newborns was significantly lower than that of the healthy controls (

3018
±
536

g versus

3380
±
492

g;

p
<
0.01

). When evaluating the subgroups of the MAT newborns, the birth weight of the methadone-exposed newborns (

2886
±
514

g) was significantly lower than that of the buprenorphine-exposed newborns (

3218
±
512

g;

p
<
0.01

). Conclusion. Medication-exposed pregnancies have a greater incidence of delayed villous maturation, a larger placental size, and a decreased fetoplacental weight ratio compared to the healthy controls. Larger long-term follow-up studies to evaluate outcomes with the presence of delayed villous maturation are needed.
Barrier Solutions of Elliptic Differential Equations in Musielak-Orlicz-Sobolev Spaces
Authors: Dong Ge , Fang Xiaochun 
Published: October 2021

In this paper, we study the solution set of the following Dirichlet boundary equation:

−
div

a

1

x
,
u
,
D
u

+

a

0

x
,
u

=
f

x
,
u
,
D
u

in Musielak-Orlicz-Sobolev spaces, where

a

1

:
Ω
×
ℝ
×

ℝ

N

⟶

ℝ

N

,

a

0

:
Ω
×
ℝ
⟶
ℝ

, and

f
:
Ω
×
ℝ
×

ℝ

N

⟶
ℝ

are all Carathéodory functions. Both

a

1

and

f

depend on the solution

u

and its gradient

D
u

. By using a linear functional analysis method, we provide sufficient conditions which ensure that the solution set of the equation is nonempty, and it possesses a greatest element and a smallest element with respect to the ordering “≤,” which are called barrier solutions.
Effectiveness of Physical Activity Interventions among Rural Cancer Survivors: A Systematic Review and Meta-Analysis
Authors: Mama Scherezade K. , Lopez-Olivo Maria A. , Bhuiyan Nishat , Leach Heather J. 
Published: October 2021

AbstractThis review estimated the effectiveness of behavior change interventions to increase physical activity (PA) among rural adult cancer survivors. PubMed Medline, CINAHL, and PsychINFO were systematically searched through July 2020. Two independent investigators screened citations to identify studies to increase PA in adults residing in rural areas who had received any cancer diagnosis. Meta-analyses were conducted to assess proportion of participants achieving PA goal, paired mean difference (MD) in aerobic PA and strength training, and retention from baseline to post-intervention. Seven studies met inclusion criteria encompassing a total of 722 participants (591 in intervention and 131 controls). Overall quality of evidence was low to medium. The pooled proportion of participants achieving PA goals (150–225 min/wk) was 39% [95% confidence interval (CI), 18%–62%]. The mean time spent engaging in aerobic PA increased from baseline to post-intervention (range, 6–52 weeks) by 97.7 min/wk (95% CI, 75.0–120.4), and the MD in time spent on strength training was 12.2 min/wk (95% CI, −8.3–32.8). The pooled retention rate was 82% (95% CI, 69%–92%) at 6 to 78 weeks. Because of the modest intervention effects, low quality of evidence, and small number of studies, further rigorously designed behavior change interventions, including randomized controlled trials with long-term follow up, are needed to confirm efficacy for increasing PA in rural cancer survivors and to test innovative implementation strategies to enhance reach and effectiveness.
Molecular and Cellular Dynamics of Aortic Aneurysms Revealed by Single-Cell Transcriptomics
Authors: Li Yanming , LeMaire Scott A. , Shen Ying H. 
Published: October 2021

The aorta is highly heterogeneous, containing many different types of cells that perform sophisticated functions to maintain aortic homeostasis. Recently, single-cell RNA sequencing studies have provided substantial new insight into the heterogeneity of vascular cell types, the comprehensive molecular features of each cell type, and the phenotypic interrelationship between these cell populations. This new information has significantly improved our understanding of aortic biology and aneurysms at the molecular and cellular level. Here, we summarize these findings, with a focus on what single-cell RNA sequencing analysis has revealed about cellular heterogeneity, cellular transitions, communications among cell populations, and critical transcription factors in the vascular wall. We also review the information learned from single-cell RNA sequencing that has contributed to our understanding of the pathogenesis of vascular disease, such as the identification of cell types in which aneurysm-related genes and genetic variants function. Finally, we discuss the challenges and future directions of single-cell RNA sequencing applications in studies of aortic biology and diseases.

Graphic Abstract:
A graphic abstract is available for this article.
ANKRD36 Is Involved in Hypertension by Altering Expression of ENaC Genes
Authors: Yan Yupeng , Wang Jin’e , Yu Liang , Cui Bing , Wang Hongrui , Xiao Xiao , Zhang Yu , Zheng Jun , Wang Jingjun , Hui Rutai , Wang Yibo 
Published: October 2021

Rationale:
Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases. Getting deep insight into the pathogenesis of hypertension is necessary.

Objective:

To investigate the role of ANK (ankyrin) repeat domain 36 (
ANKRD36
) in hypertension.

Methods and Results:

We first recruited an essential hypertension cohort and then performed genome-wide transcriptome analysis with peripheral blood mRNA.
ANKRD36
was found to be significantly lower expressed in hypertension. The anchorin repeat domain mediates a variety of protein-protein interactions. The ENaC (epithelial sodium channel) genes expression was found upregulated in human umbilical vein endothelial cells with
ANKRD36
knockdown by using Affymetrix expression profile chip. In human embryonic kidney epithelial cells and HEK293T (human embryonic kidney cells),
ANKRD36
overexpression significantly downregulated expression of ENaC genes, and
ANKRD36
knockdown upregulated their expression. The chromosome immunoprecipitation assay and yin yang 1 (
YY1
) knockdown showed the expression of ENaC was regulated by ANKRD36 via YY1, a dual-function transcription factor ubiquitously expressed in human tissues. Immunocoprecipitation and fluorescence resonance energy transfer assay confirmed the interaction between ANKRD36 and YY1. The nucleo-cytoplasmic ratio of YY1 decreased when ANKRD36 was overexpressed and also increased when ANKRD36 was knocked down. ANK2 domain of ANKRD36 was critical to its interaction with YY1.
Ankrd36
knockout mice showed higher blood pressure levels and Na
+
reabsorption, especially when fed with high-salt diet. Higher expression of ENaC genes was observed in renal tubular epithelial cells from the knockout mice, and
Yy1
knockdown mitigated the alteration.
Ankrd36
knockout mice also showed more sensitive response to ENaC inhibitor amiloride treatment.

Conclusions:

We identified that ANKRD36 was involved in blood pressure regulation by interacting with YY1 and then altering expression of ENaC genes. Lower expressed ANKRD36 in hypertension might be a potential therapeutic target, and the application of ENaC inhibitors on hypertension treatment might be extended when serum K
+
levels are closely monitored.
Effects of local infiltration of analgesia and tranexamic acid in total knee replacements: safety and efficacy in reducing blood loss and comparability to intra-articular tranexamic acid
Authors: Sivasubramanian Harish , Tan Cheryl Marise Peilin , Wang Lushun 
Published: October 2021

Abstract

Introduction:
The use of periarticular (PA) tranexamic acid (TXA) and its efficacy in comparison with intra-articular (IA) TXA have not been well explored in the literature. This retrospective cohort study aimed to compare the effects of IA and PA TXA with analgesic components in reducing blood loss and improving immediate postoperative pain relief and functional outcomes in patients after unilateral primary total knee arthroplasty (TKA).

Methods:
A total of 63 patients underwent TKA, and they were divided into the IA TXA delivery group (n= 42) and PA TXA delivery group (n = 21). All patients were administered 1 g of TXA. They also received pericapsular infiltration consisting of 0.5 mL of adrenaline, 0.4 mL of morphine, 1 g of vancomycin, 1 mL of ketorolac and 15 mL of ropivacaine. Outcomes for blood loss and surrogate markers for immediate functional recovery were measured.

Results:
Of the 63 patients, 54% were female and 46% male. The mean drop in postoperative haemoglobin levels in the PA and IA groups was 2.0 g/dL and 1.6 g/dL, respectively, and this was not statistically significant (P = 0.10). The mean haematocrit drop in the PA and IA groups was 6.1% and 5.3%, respectively, and this was also not statistically significant (P = 0.58). The postoperative day (POD) 1 and discharge day flexion angles, POD 1 and POD 2 visual analogue scale (VAS) scores, gait distance on discharge and length of hospitalisation stay were largely similar in the two groups.

Conclusion:
Our study showed that both IA and PA TXA with analgesic components were equally efficient in reducing blood loss and improving immediate postoperative pain relief and functional outcomes.
Early mobilisation following fragility hip fracture surgery: current trends and association with discharge outcomes in a local tertiary hospital
Authors: Tan Shumei , Vasireddy Aswinkumar 
Published: October 2021

Introduction:
Postoperative day 1 (POD 1) mobilisation is a key clinical indicator for the fragility hip fracture surgery population. This study aimed to evaluate the current trends of POD 1 mobilisation at our institution and to review the relationships between early mobilisation and outcomes of early functional recovery, length of stay (LOS) and discharge destination.

Methods:
In this preliminary observational study, data pertaining to demographics, premorbid function, health status, injury and surgical factors, POD 1 mobilisation status and clinical outcomes of interest were retrieved from eligible patients. Patients who attained POD 1 ambulation formed the early ambulation (EA) group, while the remaining patients formed the delayed ambulation (DA) group. Data were analysed for any significant difference between the groups.

Results:
One hundred and fifteen patients were included in the analysis. The rate of patients achieving at least sitting out of bed on POD 1 was 80.0% (n=92), which was comparable to the data available from international hip fracture audit databases. There were 55 (47.8%) patients in the EA group and 60 (52.5%) patients in the DA group. The EA group was approximately nine times more likely to achieve independence in ambulation at discharge compared to the DA group (adjusted odds ratio 9.20, 95% confidence interval 1.50–56.45; P = 0.016). There were observed trends of shorter LOS and more proportion of home discharge in the EA group compared to the DA group (P > 0.05).

Conclusion:
This is the first local study to offer benchmark of the POD 1 mobilisation status for this population. Patients who attained POD 1 ambulation had better early functional recovery.
Fisheries Co-management and Fishers’ Income in Inland Openwater Fisheries in Bangladesh
Authors: Shamsul Kabir G. M. , Mustafa Golam. 
Published: October 2021

Abstract
Community management of inland openwater fisheries in Bangladesh has introduced and practiced through the Community Based Fisheries Management (cbfm) approach with partnership arrangement of government and non-government organisations, fisher communities and other stakeholders. One of the principles behind community based fisheries management is to improve fishers’ income and reduce transaction costs efficiently. The implementation of the cbfm approach has experienced a significant contribution towards fishers’ income and transaction costs. cbfm arrangement introduced fisher led, community led and women led approach. Community based organisations (cbo s) as local institutions have been established through community participation under cbfm approach.
This paper presents and assesses the impact of cbfm approaches on fishers’ income and transaction costs in inland openwater fisheries in Bangladesh. This study might have policy implication to scale up cbfm approach to promote fishers’ income for better management of inland open water fisheries with a long term commitment.
The Paulo Freire System
Authors: Torres Carlos Alberto 
Published: October 2021

Abstract
This article discusses the origins and structure of what for the lack of a better term I will call the ‘Paulo Freire System’. Focusing on the historical experience of Angicos which catapulted Freire to world fame as an adult educator, a major claim of this article is that Freire’s work was a much more ambitious and revolutionary project than transforming adult education and literacy training becoming another landmark in the history of popular education in the region. The Angicos experience connecting public education with popular culture, the system that Freire and associates imagined in the sixties aimed for a profound and revolutionary transformation of public education in Brazil. With his exile in 1964, popular education becomes a model that could deeply affect public education worldwide. Represented theoretically in the pages of Pedagogy of the Oppressed, a pedagogical classic of the twenty first century, education is for Freire critical hermeneutics, addressing the dilemmas of citizenship building with a postcolonial ethics.
Planned Power Transition and Unexpected Crisis: Russian Responses to Belarusian Post-Election Protests
Authors: Fung Ricky Nam-Lau 
Published: October 2021

Abstract
This Policy Insight article aimed to review Russia’s policies toward Belarus since the outbreak of the post-election protests. Russia tries to minimise the impacts of the crisis in Belarus to prevent the possibilities of the redistribution of power when it faces the “2024 problem”.
Fossil wood of Syzygium from the Miocene of Guangxi, South China: the earliest fossil evidence of the genus in eastern Asia
Authors: Li Yifan , Huang Luliang , Quan Cheng , Jin Jianhua , Oskolski Alexei A. 
Published: October 2021

Abstract
A new species, Syzygium guipingensis sp. nov. (Myrtaceae), is described based on mummified fossil wood from the Miocene Erzitang Formation of Guiping Basin, Guangxi, South China. This species represents the most ancient reliable fossil record of the genus Syzygium in eastern Asia, showing the greatest similarity to the extant species S. buxifolium Hook. et Arnott. Its occurrence in the Miocene is consistent with the diversification age of the Asian lineage within Syzygium as estimated by molecular dating (11.4 Ma). The fossil record of Syzygium suggests that this genus migrated from Australia to eastern Asia in the Miocene, coincidently with the formation of island chains between these continents.
Problems of Time
Authors: van Haeften Chris 
Published: October 2021

Abstract
Herman Dooyeweerd approached time in terms of order. By contrast, Dirk Vollenhoven saw time as continuous change and becoming. Hendrik Hart, in his (1973) article “Problems of Time: An Essay,” attempts to steer a middle course between Dooyeweerd and Vollenhoven. However, Hart did not sufficiently take into account that temporality is primarily continuous succession in duration and continuous duration in succession. Nor has he been able to come to terms with the root of cosmic time.
A Brief Description of the Anhui University Shi Jing Manuscript
Authors: Huang (黄德寬) Dekuan 
Published: October 2021

Abstract
In 2015, Anhui University acquired a valuable batch of bamboo manuscripts from the Warring States period. The Anda slips have received wide attention both abroad and in China, in particular the Shi jing manuscript contained therein. This article discusses the sequence, number, and variants of the songs, titles, wording, and phrasing in the Shi jing manuscript. The final section of this article introduces the philological value of this find.
On the Nature of the Tsinghua Bamboo-Slip Manuscript Chi jiu zhi ji Tang zhi wu
Authors: Sun (孫飛燕) Feiyan 
Published: October 2021

Abstract
The nature of the Tsinghua bamboo-slip manuscript Chi jiu zhi ji Tang zhi wu is different from that of the Yi Yin shuo, which is recorded in the ‘Zhuzi lüe’ of the Han shu ‘Yiwen zhi’. This manuscript is also not a story fabricated by people in the Warring States period. It is possible that what is presented in this manuscript was a legend passed from generation to generation within Yi Yin’s lineage. Unlike Yin zhi and Yin gao, this manuscript does not belong to the Shangshu category.
The Sui Chapter of the Zhoujiazhai Daybook
Authors: Fan (凡國棟) Guodong , Luo (羅運兵) Yunbing 
Published: October 2021

Abstract
The Sui 歲 chapter of the Zhoujiazhai 周家寨 Daybook (rishu 日書) is a type of divination text with a focus on “timing,” including the formation of heaven and earth, five elements 五行, five colors 五色, five sounds 五音, and their relationships. It develops the concepts of “five periods” 五時, “four seasons” 四時 and “the engagement (and disengagement) of four seasons” 四時結（解）, and tells of the seasonal ordinances and climate of the twelve months in sequence. This kind of literature first appeared in the Daybook from Kongjiapo 孔家坡, but the text was incomplete. The Sui chapter in the Daybook from Zhoujiazhai introduced in this paper was excavated from a site adjacent to the Kongjiapo tomb, and the two daybooks are akin in terms of dating and content. Through comparison and collation, this paper proposes a translation and annotation superior to that of the published brief report, and presents a preliminary study on some problems related to the text. The paper demonstrates that there was a rule of collocation among the twelve branches in the second part of the chapter. The paper further suggests that texts like Sui ought to be classified as “theories of day selection,” and that a daybook should be classified as a combination of the techniques and the theories of day selection.
A Preliminary Analysis of Rhymed Passages in the Daybook Manuscripts
Authors: Krijgsman (武致知) Rens 
Published: October 2021

Abstract
The daybook manuscripts are miscellanies in that they gather together a range of different forms of text onto a single manuscript carrier. This article focuses on passages of rhymed text, analyzing in particular the forms, patterns, and functions of the rhymes. On this basis, I provide a number of preliminary observations on the use and context of the daybook manuscripts. The article focuses on the use of rhyme in material from the Kongjiapo 孔家坡 and Shuihudi 睡虎地 daybook manuscripts in particular, while also paying attention to related hemerological, astrological, and divinatory material from Mawangdui 馬王堆, Fangmatan 放馬灘, and the Beida 北大 manuscripts among others. These materials have a penchant for using especially Yang-group 陽部 rhymes marking the (auspicious or otherwise) results of actions and divinations, in this regard they can be further compared to genres such as prayers and philosophical sayings for instance, raising the possibility of a shared discursive practice.
Large internal variability dominates over global warming signal in observed lower stratospheric QBO amplitude
Authors: Match Aaron , Fueglistaler Stephan 
Published: October 2021

AbstractGlobal warming projections of dynamics are less robust than projections of thermodynamics. However, robust aspects of the thermodynamics can be used to constrain some dynamical aspects. This paper argues that tropospheric expansion under global warming (a thermodynamical process) explains changes in the amplitude of the Quasi-Biennial Oscillation (QBO) in the lower and middle stratosphere (a dynamical process). A theoretical scaling for tropospheric expansion of approximately 6 hPa K−1 is derived, which agrees well with global climate model (GCM) experiments. Using this theoretical scaling, the response of QBO amplitude to global warming is predicted by shifting the climatological QBO amplitude profile upwards by 6 hPa per Kelvin of global warming. In global warming simulations, QBO amplitude in the lower- to mid-stratosphere shifts upwards as predicted by tropospheric expansion. Applied to observations, the tropospheric expansion framework suggests a historical weakening of QBO amplitude at 70 hPa of 3% decade−1 from 1953-2020. This expected weakening trend is half of the 6% decade−1 from 1953-2012 detected and attributed to global warming in a recent study. The previously reported trend was reinforced by record low QBO amplitudes during the mid-2000s, from which the QBO has since recovered. Given the modest weakening expected on physical grounds, past decadal modulations of QBO amplitude are reinterpreted as a hitherto unrecognized source of internal variability. This large internal variability dominates over the global warming signal, such that despite 65 years of observations, there is not yet a statistically significant weakening trend.
Resolution of Paraneoplastic Lumbosacral Plexopathy in a Patient With Stage III Rectal Cancer after Curative Resection
Authors: Bengart Joseph J. , Chouliaras Konstantinos , Nurkin Steven 
Published: October 2021

Paraneoplastic syndromes are rare but possible manifestations of colorectal cancer. We present THE CASE of a 51-year-old female diagnosed with cT3N2 rectal adenocarcinoma who developed back pain and progressive muscle weakness during preoperative treatment. She had a rapid worsening in mobility and was ultimately ambulating with a wheelchair, despite physical therapy and conservative treatments. Extensive laboratory workup including onconeural antibodies was negative and her lower extremity electromyogram was suggestive of a subacute demyelinating lumbosacral plexopathy. After multidisciplinary discussion, the decision was made to proceed with curative resection. She had significant improvement in her weakness following resection, suggesting a paraneoplastic etiology. One year after resection, she remains free of disease and is ambulating comfortably. Onconeural antibodies can be a helpful diagnostic tool, but their absence does not rule out paraneoplastic disease. A high index of suspicion is necessary when assessing patients with atypical symptoms, particularly with the rise of colorectal cancer in young adults.