bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Soil and Weather Factors on Mulberry Root Rot Incidence in the Western Zone of Tamil Nadu, India
Authors: Saratha M. , Angappan K. , Karthikeyan S. , Marimuthu S. , Chozhan K. 
Published: December 2021

Aims: To record the occurrence of mulberry root rot disease, epidemiology, interaction of weather and soil parameters with the soil-borne pathogens in Western zone of Tamil Nadu during 2019-2020.
Study Design: Survey.
Place and Duration of Study: Surveyed in Coimbatore, Tiruppur, Erode, Dharmapuri and Krishnagiri districts of Tamil Nadu. Laboratory experiments were carried out at Department of Sericulture & Department of Plant Pathology, Tamil Nadu Agricultural University (TNAU), Coimbatore between July 2019 and Jan 2021.
Methodology: Per cent disease incidence of root rot was recorded in all surveyed gardens. To analyze the soil and weather parameters, the composite soil samples were subjected to textural analysis and weather data were collected from TNAU Agro Climate Research Centre. To predict soil temperature for all surveyed locations, the model regression equations were derived. The correlation analysis was done between per cent disease incidence, weather and soil parameters.
Results: The highest disease incidence was recorded in Nallampalli block of Dharmapuri district (54 per cent) whereas the lowest in Udumalaipettai block of Tiruppur district (0.06 per cent). The infected mulberry root samples yielded complex of soil-borne pathogens including Macrophomina phaseolina, Lasiodiplodia theobromae, Fusarium sp., and pathogenicity was proved. The results revealed that root rot incidence was recorded in all types of cultivars, significantly in ruling variety V1 irrespective of its age, soil type, spacing, and irrigation method. Soil parameters like texture, temperature and moisture content were found to augment the disease. Per cent disease incidence had significantly positive correlation with the weather factors like air and soil temperature whereas negative correlation with relative humidity and rainfall.
Conclusion: Synergism of abiotic stress factors hinders the mulberry plant health and increases its susceptibility to the soil-borne pathogens.
Nursing Students and Online Learning During COVID-19 Pandemic: A Scoping Review
Authors: George Rinu J. , Kunjavara Jibin , Kumar L. Manoj , Sam Shiny T. 
Published: December 2021

Aim: This scoping review paper aimed to overview the published research related to nursing students and online learning during the COVID-19 pandemic over the last year 2020-2021.
Methodology: Online Google Scholar Database was searched for articles related to nursing students and online learning during Covid 19 pandemic published between1st June 2020 to 1st June 2021.
Results: Initial search with key words “nursing students” found 20300 results, finally 39 articles were selected which meet the eligibility criteria. Majority of the authors (69.23 %) have an academic affiliation, only one single author (11.2 %) with clinical affiliation and those who had both academic and clinical were (28.19 %). Only (5.12 %) study applied any theory or conceptual frame work. The focuses of the studies selected were mainly (33.33 %) perception or attitude, (28.20 %) impact and satisfaction were as (20.52 %) focused on experiences and challenges faced. We could only find (5.12 %) studies those where funded. In the selection of research designs majority (46.15 %) adopted quantitative approach followed by (20.51 %) qualitative approaches and (10.25 %) mixed methods; others (23.07 %) included reports, editorials, reflective articles, opinions. About (94.8 %) studies were done without any collaboration with other disciplines only (5.12 %) studies were multidisciplinary.
Conclusion: Nursing teaching faculties swiftly responded to COVID-19 by conducting researches mainly adopting quantitative approaches. Nursing researches need more collaboration and funding.
A Case Report on Tuberculous Meningitis
Authors: Kapgate Shreya , Sharma Ranjana , Mendhe Deeplata , Wanjari Mayur 
Published: December 2021

Introduction: The most common cause of tuberculous meningitis is a hematogenous spread of mycobacteria from the lungs. tuberculous meningitis is a fatal disease. Symptoms typically worsen over time, and there are three clinical stages to the disease (prodromal phase, phase of neurological symptoms and phase of paresis)
Case Presentation: The chief complaint of a one-year-old boy was fever, irritability, vomiting, and Generalized Tonic-Clonic Seizure convulsions. The patient's pupils were found to be unequal on physical examination, prompting a repeat neuroimaging. It was done on MRI (magnetic resonance imaging) with T1 hyperintensity on T2 and restricted diffusion on DWI (diffusion-weighted imaging) he has not improved after taking treatment and the patient is on a ventilator as well, we nasogastric tube also. I was receiving treatment and will continue to do so until the end of my care.
Conclusion: In our environment, tuberculous meningitis that presents late is not uncommon. It arrived late at our medical facility. After a full recovery, the patient's comprehensive health care team collaborates to help him regain his previous level of independence and satisfaction. This report is intended to raise clinician awareness of tuberculous meningitis' unusual clinical presentation. Tuberculous meningitis is treated holistically with a focus on medical and nursing management.
Effectiveness of Remote Simulation amongst EMS Professionals in Pune, India
Authors: Rishipathak Parag , Vijayaraghavan Shrimathy , Hinduja Anand 
Published: December 2021

Introduction: The Sars CoV2 virus has spread havoc claiming millions of lives in its wake and the world health Organization (WHO) had declared it as a pandemic in 2020. Though medical education and clinical training has always laid more emphasis on face – to- face teaching and physical skill based hands-on training, lately various e-learning tools have become popular as teaching pedagogy due to the restriction of social distancing in the current COVID scenario. Simulation based learning plays a very important role in adding to non-technical skills and management of patient as a whole. Simulation through remote mode has gained major precedence in these last few years especially since the onset of COVID. The present study seeks to know the effectiveness of a single remote simulation session amongst Emergency Medical Services (EMS) professionals
Objective: To assess the effectiveness of remote simulation in the management of cardiac arrest amongst EMS professionals.
Study Design: Cross Sectional Descriptive Study.
Place of Study: Symbiosis Centre for Health Skills (SCHS), Pune India in September 2021.
Materials and Methods: The present study was conducted in September 2021, amongst 80 Emergency Medical Professionals (EMPs) from Pune, India. American Heart Association (AHA) – Pre-course Self-Assessment Questionnaire for the year 2020 was utilized for the study to assess ECG interpretation competency among EMS Professionals before and after a remote simulation session.
Results and Discussion: Time is of essence in a cardiac arrest scenario as any delay can cause exponential rise in the mortality rate. The COVID 19 era has severely restricted bedside learning and on site simulation. A healthy alternative has emerged in the form of remote simulation, which can ensure continuity of learning along with mitigation of the disease spread.
Conclusion: The findings of the study are encouraging and should be followed up with larger sample size and multiple remote simulation sessions to gain further insight into the effectiveness of this unique tool. The COVID 19 era has severely restricted bedside learning and on site simulation. A healthy alternative has emerged in the form of remote simulation, which can ensure continuity of learning along with mitigation of the disease spread.
To Assess Social Demographic Characteristics of Women with Pelvic Organ Prolapse
Authors: Taksande Vaishali Deoraoji , Ambade Shraddha Satish , Bajait Roshan Deoraoji , Bhonde Prajwal Vinayakrao , Borkar Tejaswini Shrirang , Chaudhary Shital Raju , Dhawane Pranjali Ramesh 
Published: December 2021

Introduction: One of the prevalent clinical conditions in daily gynecological treatment is pelvic organ prolapses (POP), particularly in parous women. The entity comprises vaginal wall descent and/or uterine descent. Pelvic organ prolapse is a common pelvic disorder among women.
Objective: To determine the social demographic characteristics and types of pelvic organ prolapse and to find out the association between social demographical characteristics with pelvic organ prolapse.
Methods: The descriptive survey was used and the sampling technique was non probability convenient sampling technique and the sample size was 60.
Results: Twenty six (43.3%) women were belongs to in the age group of 33-40 years. 54 (90%) of women were married.29 (48.3% ) of women never had abortion. 26 (43.3%) of women had normal delivery whereas 17(28.3) had instrumental delivery .19 (31.3%) of women had perineal tear, 20 (33.30%) of women had cervical tear in previous pregnancy . 21(35% ) of women had cystocele whereas 20(33.3) has rectocele . There is significance association between the of age of women, marital status, occupation, Place of previous delivery, type of previous delivery, complications during previous labour except the parity with pelvic organ prolapse.
Conclusion: Pelvic organ prolapse is common gynecological condition .The patients are relatively middle age group. Parity, Occupation, Injuries to birth canal was may be contributory to severity of pelvic organ prolapse.
Comparative analysis of two mathematical algorithms for the calculation of computed tomography perfusion parameters in the healthy and diseased pancreas
Authors: Pan Kehua , Wang Hongqing , Chen Xiaoyu , Ye Xiaocui , Zhang Zhao , Chen Xiao , Jia Xiufen 
Published: December 2021

AbstractBackgroundThe maximum slope (MS) and deconvolution (DC) algorithms are commonly used to post‐process computed tomography perfusion (CTP) data. This study aims to analyze the differences between MS and DC algorithms for the calculation of pancreatic CTP parameters.MethodsThe pancreatic CTP data of 57 patients were analyzed using MS and DC algorithms. Two blinded radiologists calculated pancreatic blood volume (BV) and blood flow (BF). Interobserver correlation coefficients were used to evaluate the consistency between two radiologists. Paired t‐tests, Pearson linear correlation analysis, and Bland–Altman analysis were performed to evaluate the correlation and consistency of the CTP parameters between the two algorithms.ResultsAmong the 30 subjects with normal pancreas, the BV values in the three pancreatic regions were higher in the case of the MS algorithm than in the case of the DC algorithm (t = 39.35, p < 0.001), and the BF values in the three pancreatic regions were slightly higher for the MS algorithm than for the DC algorithm (t = 2.19, p = 0.031). Similarly, among the 27 patients with acute pancreatitis, the BV values obtained using the MS methods were higher than those obtained using the DC methods (t = 54.14, p < 0.001). Furthermore, the BF values were higher with the MS methods than the DC methods (t = 8.45, p < 0.001). Besides, Pearson linear correlation and Bland–Altman analysis showed that the BF and BV values showed a good correlation and a bad consistency between the two algorithms.ConclusionsThe BF and BV values measured using MS and DC algorithms had a good correlation but were not consistent.
Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents
Authors: Wang Changlong , Wang Xiaojun , Zhang Wei , Ma Ding , Li Feng , Jia Rongrong , Shi Min , Wang Yugang , Ma Guanghui , Wei Wei 
Published: December 2021

AbstractFerritin (Fn) is considered a promising carrier for targeted delivery to tumors, but the successful application in vivo has not been fully achieved yet. Herein, strong evidence is provided that the Fn receptor is expressed in liver tissues, resulting in an intercept effect in regards to tumor delivery. Building on these observations, a biomineralization technology is rationally designed to shield Fn using a calcium phosphate (CaP) shell, which can improve the delivery performance by reducing Fn interception in the liver while re‐exposing it in acidic tumors. Moreover, the selective dissolution of the CaP shell not only neutralizes the acidic microenvironment but also induces the intratumoral immunomodulation and calcification. Upon multiple cell line and patient‐derived xenografts, it is demonstrated that the elaboration of the highly flexible Fn@CaP chassis by loading a chemotherapeutic drug into the Fn cavity confers potent antitumor effects, and additionally encapsulating a photosensitizer into the outer shell enables a combined chemo‐photothermal therapy for complete suppression of advanced tumors. Altogether, these results support Fn@CaP as a new nanoplatform for efficient modulation of the tumor microenvironment and targeted delivery of diverse therapeutic agents.
Vibrational Strong Coupling between Surface Phonon Polaritons and Organic Molecules via Single Quartz Micropillars
Authors: Liu Kaizhen , Huang Guangyan , Li Xiang , Zhu Guangpeng , Du Wei , Wang Tao 
Published: December 2021

AbstractVibrational strong coupling (VSC), the strong coupling between optical resonances and the dipolar absorption of molecular vibrations at mid‐infrared frequencies, holds the great potential for the development of ultrasensitive infrared spectroscopy, the modification of chemical properties of molecules, and the control of chemical reactions. In the realm of ultracompact VSC, there is a need to scale down the size of mid‐infrared optical resonators and to elevate their optical field strength. Herein, by using single quartz micropillars as mid‐infrared optical resonators, the strong coupling is demonstrated between surface phonon polariton (SPhP) resonances and molecular vibrations from far‐field observation. The single quartz micropillars support sharp SPhP resonances with an ultrasmall mode volume, which strongly couples with the molecular vibrations of 4‐nitrobenzyl alcohol (C7H7NO3) molecules featuring pronounced mode splitting and anticrossing dispersion. The coupling strength depends on the molecular concentration and reaches the strong coupling regime with only 7300 molecules. The findings pave the way for promoting the VSC sensitivity, miniaturing the VSC devices, and will boost the development of ultracompact mid‐infrared spectroscopy and chemical reaction control devices.
The Effects of Various Surface Coatings of Gold Nanorods on Toxicity, Neuronal Localization, Microstructural Alterations, and In vitro/In vivo Biodistribution
Authors: Ozcicek Ilyas , Aysit Nese , Cakici Cagri , Ayturk Nilufer Ulas , Aydeger Asel , Erim Umit Can 
Published: December 2021

AbstractWith the development of gold nanorods (AuNRs) for a number of biomedical applications, understanding their various biological effects has become important. Surface functionalization of AuNRs is attracting increasing attention with regard to toxicity, cellular uptake, localization, therapeutic potential, and biodistribution. The aim of the study is to synthesis of stable AuNRs functionalized with polyethylenimine (PEI) and polyethylene glycol (PEG), multiparametric investigation of their cellular effects on the dorsal root ganglion (DRG) primary sensory neurones, evaluation of the in vitro/in vivo biodistribution, and toxicity. PEI and PEG surface coatings increased both biocompatibility and biodistribution of the AuNRs. With the near‐infrared laser of the two‐photon microscope, very strong radiations are taken from the nucleolus parts of the neurones particularly and these localizations of the AuNRs‐PEI are confirmed by the transmission electron microscope images. Inductively coupled plasma mass spectrometry analysis shows the presence of AuNRs in liver, spleen, kidney, heart, blood, and brain within a 30 day period. It is observed that the surface coatings of the AuNRs significantly increase the biodistribution and biocompatibility. The surface functionalization, stability, and biocompatibility of the AuNRs are very important parameters for the potential nanotheranostic applications of AuNRs in the next studies.
Chalcogenide Perovskites: Tantalizing Prospects, Challenging Materials
Authors: Sopiha Kostiantyn V. , Comparotto Corrado , Márquez José A. , Scragg Jonathan J. S. 
Published: December 2021

AbstractChalcogenide perovskites have recently emerged into the spotlight as highly robust, earth abundant, and nontoxic candidates for various energy conversion applications, not least photovoltaics (PV). Now, a serious effort is required to determine if they can emulate the PV performance of the better‐known, part‐organic halide perovskites, in applications such as tandem solar cells. This review summarizes the surprisingly large body of literature pertaining to chalcogenide perovskites, which have been investigated for many years despite only recently being considered for applications. The confusing variety of claims coming from computational materials discovery is clarified, and it is specified which chalcogenide perovskites actually exist and should form the focus of experimental work. The highly interesting optoelectronic and transport properties of the known materials at their current stage of development are summarized, which makes a clear case for investigating them further. The existing synthesis literature is collated, which provides some important and possibly unnoticed clues to experimentalists grappling with these somewhat challenging materials. The authors hope that the highlighting of this information will facilitate further exciting studies, better approaches, and new progress for chalcogenide perovskites.
Optimized Infrared LED and Its Use in an All‐HgTe Nanocrystal‐Based Active Imaging Setup
Authors: Bossavit Erwan , Qu Junling , Abadie Claire , Dabard Corentin , Dang Tung , Izquierdo Eva , Khalili Adrien , Gréboval Charlie , Chu Audrey , Pierini Stefano , Cavallo Mariarosa , Prado Yoann , Parahyba Victor , Xu Xiang Zhen , Decamps‐Mandine Armel , Silly Mathieu , Ithurria Sandrine , Lhuillier Emmanuel 
Published: December 2021

AbstractNanocrystals (NCs) have reached a high level of maturity, enabling their integration into optoelectronic devices. The next challenge is the combination of several types of devices into one complex system to achieve better on‐chip integration. Here, an all‐HgTe‐NC active imaging setup operating in the short‐wave infrared (IR) is focused on. First, the design of an optimized IR light‐emitting diode (LED) is focused on. It is shown that a halide technology processing enables an increase of the electroluminescence signal by a factor of 3, while preserving a low turn‐on voltage and a high brightness (3 W sr−1 m−2). Then the degradation mechanism of this LED under continuous operation is unveiled and a shift from band edge to trap emission is shown. This degradation process can be strongly reduced thanks to the encapsulation and the thermal control of the LED. Lastly, the IR emission of the LED is imaged using a focal plane array whose active layer is also made of HgTe NCs, paving the way for all‐NC‐based active imaging setups.
Low Inorganic Phosphate Stress Inhibits Liver Cancer Progression: from In Vivo to In Vitro
Authors: Bi Qiu‐Chen , Luo Rong‐Guang , Li Yan‐Shu , Zhao Jun , Fu Xin , Chen Hong , Lv Yang‐Feng , Liu Zhi‐Xing , Liang Qing‐Rong , Tang Qun 
Published: December 2021

AbstractMetabolic stress (for example, low pO2, low pH) stimulates cancer progression in a complex and largely unresolved manner. Excessive inorganic phosphate burden is being considered as another stimulator, until now there is no well‐designed study to examine the potential benefits of reducing phosphate burden on cancer progression. Sevelamer microspheres, a polymeric phosphate binder, are introduced as embolic material for interventional treatment of rabbit VX2 liver cancer model. This technique is named as “transarterial sevelamer embolization (TASE).” The microspheres prove to be highly biocompatible, and TASE is found to be a safe local‐regional technique. Compared with conventional transarterial chemoembolization (TACE), TASE is found to not only occlude the tumor‐feeding vessel, but simultaneously deplete intratumoral inorganic phosphate (Pi), thereby inducing severe necrosis as well reducing metastasis and recurrence. Reduced Pi stress inhibits tumor vascularity, invasion, and metastasis by downregulating the angiogenic factors and oncoprotein expression. Energy metabolomics indicate that Pi stress also suppresses tumor anaerobic glycolysis and glutaminolysis. This systemic anti‐cancer effect indicates a promising new application for sevelamer and TASE as a potential alternative to conventional TACE for liver cancer treatment.
8p23.1 deletion: Look out for left ventricular hypertrabeculation and not only congenital heart diseases. Single‐center experience and literature revision
Authors: Cicenia Marianna , Alesi Viola , Orlando Valeria , Magliozzi Monia , Di Tommaso Silvia , Iodice Francesca G. , Pompei Emanuela , Toscano Alessandra , Digilio Maria C. , Drago Fabrizio , Novelli Antonio , Baban Anwar 
Published: December 2021

AbstractDeletions involving the distal portion of the short arm of chromosome 8(8p23.1) show a high phenotypic variability. Congenital heart diseases (CHD) are often described. GATA4 when mutated or deleted is reported to be involved in cardiac morphogenesis. Only twice, left ventricular non compaction (LVNC) was reported in literature in association with 8p23.1 deletion. The present cohort includes five new patients with 8p23.1 deletions including GATA4. The spectrum of CHD is variable. Moreover, in four patients, LV hypertrabeculation was detected and in the fifth LVNC was recognized. Literature revision identified 45 patients with 8p23.1 deletions (encompassing GATA4) and heart involvement. It included wide spectrum of CHD including: heterotaxy spectrum 7/45 (15, 6%), atrioventricular canal 14/45 (balanced 3/45 including two of them with hypoplastic aortic arch; unbalanced 4/45, Fallot—AVC 1/45, partial AVC 3/45, unspecified 3/45), predominant major left heart lesions included 2/45 (4, 4%): interrupted aortic arch and hypoplastic left heart syndrome. Left ventricular hypertrabeculation might be potentially underestimated in patients with 8p23.1 deletion. These might suggest the importance of including microarray analysis in this group of patients. Moreover, 8p23.1 microdeletion or GATA4 variants can be considered in heterotaxy genetic panels.