bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wnt5a Protects Motor Neuron in Amyotrophic Lateral Sclerosis by Regulating Wnt/Ca2+ Signaling Pathway
Authors: Liu Jinmeng , Zhou Fenghua , Guan Yingjun , Zhao Zhenhan , Meng Fandi , Wang Xuemei , Jiang Xin , Zhang Haoyun , Zhang Lingyun , Wang Qing , Chen Yanchun 
Published: October 2021

Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that lead to the degeneration and death of motor neurons (MNs). Wnt signaling participates in multiple neurodegenerative processes. Wnt5a is a critical signaling molecule in Wnt signaling pathway. Intracellular Ca2+ homeostasis is disrupted in a number of neurodegenerative diseases, and Ca2+/Calmodulin dependent protein kinase II (CaMKII) involved in various diseases associated with Ca2+ signaling abnormalities. Here, we found that Wnt5a modulated MNs degeneration during ALS. CaMKII is a key effector of signals derived from Wnt/Ca2+ signaling pathway. Its main subtypes CaMKII-α and CaMKII-β were down-regulated in the spinal cord of SOD1G93A transgenic mice (ALS mice) and SOD1 mutant motor neuron like hybrid (NSC-34) cells. In addition, results showed that CaMKII-α and CaMKII-β were positively regulated by Wnt5a in vitro. Using specific CaMKII inhibitor and activator, we found that Wnt5a promoted NSC-34 cells viability and proliferation, inhibited cells apoptosis and promoted cells neurite outgrowth via the Wnt/Ca2+ signaling pathway. These results indicate that Wnt5a confers neuroprotection by promoting neuronal proliferation, inhibiting cell apoptosis and promoting neurite growth through Wnt/Ca2+ signaling pathway. Therefore, targeting Wnt5a can be an effective strategy to treat ALS.
Combination of G-CSF Improves Radiation Response and Generate Abscopal Effects in Patients With NSCLC
Authors: Yin Tianwen , Wang Duoying , Wang Peiliang , Yu Jinming , Teng Feifei 
Published: October 2021

Abstract
Backgrounds:

Local radiation could enhance immune response that mediates tumor regression. Recent studies focus on adding immunotherapy to RT to improve treatment response and induce abscopal response. As a stimulator for granulocytes, the clinical anticancer effects of granulocyte-colony stimulating factor (G-CSF) are still controversial. In this study, we evaluated the synergistic effect of radiotherapy with G-CSF in patients with NSCLC, using a propensity-score (PS) matching method.
Results

After matching, 333 patients in the G-CSF group and 333 patients in the observation group were included. With a median follow-up of 18.4 months, combination with G-CSF significantly improved PFS (median, 12.1ms vs. 7.3ms, p<.001). Multivariate analysis revealed that N stage, M stage, BED and administration of G-CSF were independent factors for PFS. Combination with G-CSF significantly improves abscopal response of radiotherapy (26.8% vs. 14.8% p=.001). Synchronous chemotherapy showed a tendency toward a favorable indicator for abscopal response, but the difference did not reach statistical significance (p=.089).
Methods

From 2000 to 2018, 1312 patients with NSCLC received definite or palliative radiotherapy were included, of whom 468 (35.7%) patients received G-CSF during radiotherapy. Patients in the G-CSF group were matched in a 1:1 ratio according to their PS to the observation group with a caliper of 0.01.
Conclusion

Concurrent administration of G-CSF improved radiation response significantly and generated abscopal effects in NSCLC. It indicated that the combination of radiotherapy and G-CSF is potential a new strategy and should be further evaluated in prospective clinical trials.
Crystallographic Principal Modulation and Metal Core – Crystal Structure Exchangeable: Computational And Molecular Docking Simulation
Authors: Sayed Doaa S. El 
Published: October 2021

Abstract
Keeping in mind, the structural analysis can be modified and regulated with computational background then advances in complex structural analysis thereof. Crystallographic data of metal complexes can be modulated to form a huge number of other metal complexes that can be synthesized and applied in recent further fields. The crystal structure of Pd complex was studied as previously reported and identified to be exchanged with other metals such Zn and Ni. DFT methodology was applied to investigate the difference in electronic properties of these complexes-exchangeable metals. Spectroscopic studies were performed to compare the difference in results. Hirschfeld surface analysis deeply illustrated the intermolecular contacts of the reported Pd crystal structure. Molecular docking simulation was applied on the previously synthesized complex and the investigated ones using E-coli protein target with comparison in details.
Using explainable deep learning in da Vinci Xi robot for tumor detection
Authors: Azad Rohan Ibn , Mukhopadhyay Subhas , Asadnia Mohsen 
Published: October 2021

Abstract
Deep learning has proved successful in computer-aided detection in interpreting ultrasound images, COVID infections, identifying tumors from computed tomography (CT) scans for humans and animals. This paper proposes applications of deep learning in detecting cancerous cells inside patients via laparoscopic camera on da Vinci Xi surgical robots. The paper presents method for detecting tumor via object detection and classification/localizing using GRAD-CAM. Localization means heat map is drawn on the image highlighting the classified class. Analyzing images collected from publicly available partial robotic nephrectomy videos, for object detection, the final mAP was 0.974 and for classification the accuracy was 0.84.
Comparative Effectiveness of Enhanced Patient Instructions for Bowel Preparation Before Colonoscopy: Network Meta-analysis of 23 Randomized Controlled Trials
Authors: Tian Xu , Yi Li-Juan , Han Yang , Chen Hui , Liu Xiao-Ling , Chen Wei-Qing , Jiménez-Herrera Maria F 
Published: October 2021

Background
Various enhanced patient instructions (EPIs) have been used for bowel preparation (BP) and our previous meta-analysis also demonstrated the efficacy of EPIs in increasing the colonic polyp and adenoma detection rates; however, the optimal method for adequate BP has not yet been developed.

Objective
We performed a network meta-analysis to determine the optimal instructions.

Methods
We searched for randomized controlled trials (RCTs) comparing the effectiveness of EPIs with each other or standard patient instructions (SPIs) for BP. We performed direct and Bayesian network meta-analyses for all instructions and used the GRADE (Grading of Recommendations Assessment, Development and Evaluation) criteria to appraise the quality of evidence.

Results
We included 23 RCTs (7969 patients) comparing 10 different instructions. In direct meta-analyses, most of the EPIs, except visual aids and mobile apps, increased the adequate preparation rate (APR). Network meta-analyses showed that additional explanations were superior to visual aids (odds ratio [OR] 0.35, 95% CI 0.19-0.59), telephone calls (OR 0.62, 95% CI 0.37-0.99), educational videos (OR 0.79, 95% CI 0.5-0.77), and mobile apps (OR 0.33, 95% CI 0.14-0.68) with low-to-high-quality evidence; newly designed booklets (OR 3.28, 95% CI 1.59-6.16), SMS text messaging (OR 2.33, 95% CI 1.28-3.91), telephone calls (OR 1.86, 95% CI 1.03-1.78), educational videos (OR 2.33, 95% CI 1.40-3.65), and social media applications (OR 2.42, 95% CI 1.4-3.93) were superior to visual aids and mobile apps with low-to-high-quality evidence. SMS text messaging, telephone calls, and social media applications increase adherence to and satisfaction with the BP regime. Social media applications reduce the risk of adverse events (AEs). Telephone calls and social media applications increase the polyp detection rate (PDR).

Conclusions
Newly designed booklets, telephone calls, educational videos, and social media applications can improve the quality of BP. Telephone calls and social media applications improve adherence to and satisfaction with the BP regime, reduce the risk of AEs, and increase the PDR.

Trial Registration
INPLASY (International Platform of Registered Systematic Review and Meta-analysis Protocols) INPLASY2020120103; https://inplasy.com/inplasy-2020-12-0103/
Why Much of the Liberal Left Can Now be Termed ‘Regressive’: Discourses on Trump, Immigration, and Islam
Authors: Lataster Raphael , Hasan Rumy 
Published: October 2021

Abstract
We find much of the discourse from the soi disant progressive politicians, media and academy to be misinformed, hypocritical, and even regressive. This applies to discussions about politicians such as President Donald Trump and Hillary Clinton, and especially concerns the issues of Islam and immigration. We argue that much of the contemporary liberal left appears to be more intolerant, more Orwellian, than its traditional rivals on the right [while recognising that there are differences between those who describe themselves as ‘liberals’ or ‘leftists’, including moderate left, centre left, far left etc., we have decided to use the portmanteau ‘liberal left’ as this equates to the more generally agreed upon signifier ‘progressive’].
Popper’s Paradox of Tolerance: An Examination of Segregated Muslim Neighbourhoods in Modern Britain
Authors: Hasan Rumy 
Published: October 2021

Abstract
The twenty first century has witnessed a heightened interest in Muslim settlers in western democracies. In Britain, following the suicide bombings of 9/11 and particularly in the aftermath of the 7th July 2005 bombings in London, much of this focus has been on the threat of terror attacks emanating from radicalised Muslims. It is clearly the case that the same focus also applies to other west European countries which have witnessed similar attacks. The question arises as to the kind of milieu in which domestic jihadist perpetrators have been raised and live. In most cases—though not all—an upbringing in segregated Muslim neighbourhoods is a recurring theme. These can be deemed ‘closed communities’, yet they are situated in open societies underpinned by a secular, liberal democratic polity. This paper provides reasons and evidence for the epithet of closed communities with respect to Muslims in Britain and explores how these—in many significant respects—differ from mainstream, liberal, secular society. The tensions that inevitably arise are considered together with their implications. The inspiration for this paper stems from Karl Popper’s The Open Society and its Enemies.
The Game of Poker Chips, Dominoes and Survival
Authors: Goldstein Larry 
Published: October 2021

Abstract
The Game of Poker Chips, Dominoes and Survival fosters team building and high level cooperation in large groups, and is a tool applied in management training exercises. Each player, initially given two colored poker chips, is allowed to make exchanges with the game coordinator according to two rules, and must secure a domino before time is called in order to ‘survive’. Though the rules are simple, it is not evident by their form that the survival of the entire group requires that they cooperate at a high level. From the point of view of the game coordinator, the di culty of the game for the group can be controlled not only by the time limit, but also by the initial distribution of chips, in a way we make precise by a time complexity type argument. That analysis also provides insight into good strategies for group survival, those taking the least amount of time. In addition, coordinators may also want to be aware of when the game is ‘solvable’, that is, when their initial distribution of chips permits the survival of all group members if given su cient time to make exchanges. It turns out that the game is solvable if and only if the initial distribution contains seven chips that have one of two particular color distributions. In addition to being a lively game to play in management training or classroom settings, the analysis of the game after play can make for an engaging exercise in any discrete mathematics course to give a basic introduction to elements of game theory, logical reasoning, number theory and the computation of algorithmic complexities.
The effect of radiation therapy and chemotherapy on malignant craniopharyngioma: A review
Authors: Elarjani Turki , Alhuthayl Meshari Rashed , Alhindi Hindi , Kanaan Imad N 
Published: October 2021

Background:
Malignant craniopharyngioma is a rare tumor with few published case reports. It can form de novo or transform from a benign variant and is associated with a dismal survival rate. We reviewed the literature for all published cases and studied the effect of radiation on the rate of malignant transformation. We analyzed the effect of chemotherapy on survival.

Methods:
We used various search engines to locate literature from 1980 onward and identified 31 case reports, one of which was excluded. Statistical analysis using the SAS software was conducted, and a significant value was identified if P < 0.05.

Results:
There was equal distribution among male and female patients. The average age at malignant diagnosis is 31.11 years (±15.16) and 12.19 years (±8.41) for the average interval of benign tumor progression to malignancy. The most common clinical presentation was visual loss and/or field deficits in 26/30 patients (86%). Almost 11/30 patients (37%) had endocrinological deficits, with panhypopituitarism as the most common in 8/11 patients (73%). Fifteen patients received radiation before malignant transformation (47%) and demonstrated no effect on malignant transformation (P = 0.379). Gross total resection was achieved in 2/30 patients. The average time to mortality postoperatively is 5.3 months ± 4.3. Ten patients received chemotherapy, and five were alive at last follow-up (P = 0.115).

Conclusion:
Malignant craniopharyngioma carries a dismal prognosis with no apparent benefits of radiation therapy and chemotherapy on survival.
Roman Mosaics of Antequera. An Overview
Authors: VARGAS-VÁZQUEZ Sebastián , ROMERO PÉREZ Manuel 
Published: October 2021

The present-day city of Antequera, in the province of Malaga, Spain, dominates an extensive territory encompassing numerous archaeological sites from different eras. The urban centres of Singilia Barba, Anticaria and Aratispi, belong to the Roman period, now only offering us two mosaics, and a good number of rural properties, from which most of the set of Antequera mosaics come.
Within the Antequeran mosaic repertoire, the geometric mosaic occupies a special place, with specimens of great beauty and excellent design, for example those in the majestic Roman villa of La Estación. From a figurative point of view, Antequera has beautiful specimens, such as the Oceanus mosaic of the baths of Santa María and that of the Erotes and Priapus figures of the Roman villae of La Estación and Bobadilla, respectively. Particularly, the Roman villa of Caserío Silverio has a heritage consisting of a large number of figurative representations, highlighting the imposing, although poorly preserved, pavement of the triclinium. This mosaic must have contained a scene related to the mythology of water, of which singular fragments are preserved, such as the representation of the Tiber River and some epigraphic verses extracted from book IV of Vergil’s Georgics.
Implementation Word2Vec for Feature Expansion in Twitter Sentiment Analysis
Authors: Naufal Adi Nugroho  , Erwin Budi Setiawan  
Published: October 2021

Abstract
Twitter is a microblog-based social media site launched on July 13, 2006. In March 2020, 476.696 tweets about the government policy in COVID-19 spread on Twitter were captured by the Institute for Development of Economics and Finance (Indef). Government policy has a standard meaning, namely a decision systematically made by the government with specific goals and objectives relating to the public interest, whether carried out directly or indirectly. Sentiment analysis analyzes people’s opinions, sentiments, evaluations, attitudes, and emotions from written language. In this decade, Sentiment Analysis is has become a trendy research area. The purpose of this paper is to focus how to implement word2vec using similarity word as a feature expansion for minimize the vocabulary mismatch in Twitter Sentiment Analysis using “word embeddings”. This research contains 11.395 tweets for a dataset, where the dataset will be used in two classifications: Support Vector Machine Algorithm and Artificial Neural Network Algorithm. The output of Word2Vec will be used for feature expansion in this research, where the algorithm of expansion will check in each row in the corpus where has a similarity vector with that word and will replace the word with the similarity of this words if the value is 0. The dataset in Feature Expansion is using 142.545 articles from Indonesian media. The result of this research is ANN is better than SVM, where the ANN without feature expansion gets 68.89 % and using feature expansion gets 72.58 %. For SVM, the final accuracy without feature expansion is 63.95 %, and using feature expansion gets 68.56 %. This research proves that feature expansion can improve the final accuracy.
Estimating of Survival Function under Type One Censoring Sample for Mixture Distribution
Authors: S. Abadi Qesma , H. AL-Kanani Iden 
Published: October 2021

In this article, it is interesting to estimate and derive the three parameters which contain two scales parameters and one shape parameter of a new mixture distribution for the singly type one censored data which is the branch of right censored sample. Then to define some special mathematical and statistical properties for this new mixture distribution which is considered one of the continuous distributions characterized by its flexibility. Next, using maximum likelihood estimator method for singly type one censored data based on the Newton-Raphson matrix procedure to find and estimate values of these three parameter by utilizing the real data taken from the National Center for Research and Treatment of Hematology/University of Mustansiriyah for leukemia diseases. After that we find and derive the estimate of probability density function, estimate survival function and finally estimate the hazard function.
Synthesis and some Features of Three-Phases Polymer/Metal/Ceramic Multilayers Nanocomposite
Authors: S. Abbas Al-Khafaji Raghad 
Published: October 2021

Layer by layer development two features of pulsed laser deposition PLD, with a high kinetic energy and sharp instantaneous deposition rating. Layered films of polymer/metal/ceramic nanocomposites consisting of polystyrene PS(as substrate) , tin Sn and cadmium oxide CdO were deposited by PLD. Structure for layered samples were measured by XRD X ray diffraction, there were appearance of peaks which reflected to formation of new compounds result of reaction between layers. Particles size was calculated using two methods and it give nanoscale. Microstrain was also calculated and exhibited high value (0.01) for sample p/m.
Retos de inclusión comunitaria
Authors: Muñoz Gálvez Jazmín 
Published: October 2021

El presente análisis sobre retos de inclusión y participación comunitaria se inscribe en el contexto de la crisis financiera y sanitaria global, especialmente en el panorama latinoamericano presentado por el último informe de la CEPAL (2021), donde se realizan una serie de recomendaciones con base a un modelo de democracia desarrollista y de autonomía democrática que posea como fin una mayor equidad y desarrollo humano en la región. La relación entre el principio de autonomía democrática y el acceso a derechos sociales, económicos, políticos y culturales se considerará complementario a los procesos de participación comunitaria y social de carácter no estatal.
Mental health sequelae of bone cancer: A narrative review
Authors: Tsagkaris Christos , Desse Dimitra , Laskaratou Emmanouela Dionysia 
Published: October 2021

Introduction: Bone cancer causes a significant mental health burden. Although the mental health implications of cancer as a whole have been widely discussed, there is limited evidence regarding the psychiatric and psychological sequelae of malignant and benign bone neoplasms in particular.
Purpose: To summarize the scientific literature, present relevant knowledge gaps and discuss a number of recommendations. Methodology: The authors searched Pubmed/Medline and Google Scholar with keywords (mental health, bone cancer, musculoskeletal neoplasms, psychiatric comorbidities). When appropriate, MeSH terms and Boolean operators were used. Relevant peer reviewed studies published in English, French or German until 05 May 2021 were included.
Results and Discussion: Loss of mobility, decrease of physical activity, chronic pain and amputations in combination with patient’s previous psychiatric history, socioeconomic conditions, cancer biology and treatment-related side effects undermine the mental wellbeing of patients and carers. Since March 2020, the COVID-19 pandemic has posed an additional burden, which is yet to be comprehensively evaluated.
Conclusion: More research and solid action towards the integration of mental health care into the management of bone cancer is crucial
herramientas de detección precoz de problemas relacionados con el alcohol para profesionales sanitarios
Authors: Béjar Prado Luis María 
Published: October 2021

Los problemas relacionados con el consumo de alcohol constituyen un grupo muy heterogéneo de problemas de diversa índole: social, psicológica y física, que están asociados al consumo excesivo de alcohol, tanto de forma ocasional como regular. En la Unión Europea, estos problemas tienen un notable impacto sobre la mortalidad, con unas 115.000 muertes anuales causadas en personas de hasta 70 años, y sobre la discapacidad, el alcohol es el tercero entre veintiséis factores de riesgo de mala salud, solo por detrás de tabaco e hipertensión arterial. El objetivo es poner de manifiesto, el importante papel de los profesionales sanitarios, en especial el médico de familia y médico de salud laboral, e inclusive farmacéuticos, en la detección precoz del consumo excesivo de alcohol y de los problemas relacionados a través del uso de herramientas sencillas y fácilmente accesibles. Rev.cienc.biomed. 2011; 2 (1): 86-90
Раритетна компонента лісових фітоценозів Західно- та Центральнополіського лісогосподарського округу України
Authors: Bondaruk M. A. , Tselishchev O. G. 
Published: October 2021

Робота містить аналіз стратегії диференційованої охорони популяцій раритетних видів лісової флори України та їхніх локалітетів на основі дослідження еколого-фітоценотичних особливостей і причин раритетності, моніторингу чисельності та поширення в певних регіонах. На ділянках моніторингу лісів 1-го рівня (280 ділянок) у межах Західно- та Центральнополіського округу Поліської лісогосподарської області України досліджено стан популяцій раритетних видів рослин (рясність-покриття та участь у складі рослинного покриву), проаналізовано їхню приуроченість до певних деревостанів і типів лісу та розповсюдження в лісових фітоценозах. Визначено регіональні особливості причин раритетності видів лісової флори й запропоновано заходи щодо їхньої охорони, які охоплюють регулярне проведення моніторингових спостережень (раз на 5 років), виділення особливо захисних лісових ділянок або особливо цінних для збереження територій (ОЦЗ 1) під час FSC сертифікації лісогосподарських підприємств на ділянках із життєздатними популяціями раритетних видів та перегляд регіонального охоронного статусу окремих видів.