bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical analysis on fracture initiation from radial micro‐hole in anisotropy formation
Authors: Li Yumei , Zhang Tao , Zheng Yiming , Zhang Jinghua , Wen Tao , Sun Shibin 
Published: October 2021

AbstractThe radial jet drilling (RJD) technology is typically developed to open multiple lateral micro‐holes from a main wellbore to the formation. The multiple groups of 3D numerical models of radial micro‐holes through a main well are built by incorporating the pore hydro‐mechanical coupling effects. A number of sensitivity analyses were conducted on the effects of the radial jetting azimuth, the stress anisotropy, and the elastic anisotropy on the rock fracture initiation of the micro‐holes. As revealed from the results, the fracture initiation from the micro‐hole exhibited the diversified characteristics with the increase in the jetting azimuth of the micro‐hole. On the whole, the fracture initiation point was concentrated at the maximum principal stress. Thus, the jetting azimuth of the nozzle was recommended to be designed in the interval of 0°‐30°. A higher elastic modulus anisotropy ratio K and a lower Poisson's ratio anisotropy ratio K′ caused the significant rigidity characteristics of the rock, which increased the possibility of fracture initiation in the horizontal direction; a lower elastic modulus anisotropy ratio K and a higher Poisson's ratio anisotropy ratio K′ caused the strong rigidity characteristics, so the rock could not easily fracture in the vertical direction. Several suggestions were given that the rock is easy to be broken by selecting a smaller jetting azimuth angle and a more significant in‐situ stress difference. The numerical simulation results agree well with field experiment results, with an average accuracy of 97.17%. The proposed numerical model has a good performance in predicting the fracture initiation pressure of the radial micro‐hole in anisotropy formation.
Enhanced characterization and modeling of A‐MPDU aggregation for IEEE 802.11n WLANs
Authors: Jabri Issam , Mansour Kaouther , Al‐Oqily Ibrahim , Ezzedine Tahar 
Published: October 2021

AbstractThe MAC protocol data unit aggregation (A‐MPDU) and Block Acknowledgment (Block Ack) techniques are probably the most relevant 802.11 MAC layer enhancements. In spite of being tremendously studied in the literature, recent research activities have revealed that the available analytical models for those techniques do not capture the impact of the Block Ack window limit on the aggregated frame size. This provokes errors in the estimation of the average aggregation size that raise up toin erroneous environments. Throughout this work, we use Markovian techniques to design a more accurate model for 802.11n MAC layer. Our model reflects the impact of the conventional A‐MPDU acknowledgment method on the A‐MPDU aggregation size. The accuracy of our model has been validated through ns‐3 simulations. A comparison with two analytical models of 802.11n MAC sub‐layer has been also carried on. In depth analysis have been conducted to investigate the behavior of A‐MPDU aggregation scheme under different channel conditions and its impact on the overall network performance. Assessments have shown that our model is more rigorous than existing models. Besides, we have proved that A‐MPDU frame aggregation technique is extremely sensitive to channel conditions variation because of the effect of the Block Ack window limit on the maximum aggregation size.
The microbial community, biogenic amines content of soybean paste, and the degradation of biogenic amines by Lactobacillus plantarum HM24
Authors: Li Siyi , Du Xue , Feng Lu , Mu Guangqing , Tuo Yanfeng 
Published: October 2021

AbstractSoybean paste was a traditional fermented product in Northeast China, mainly fermented by molds, yeast, Bacillus, and lactic acid bacteria. This study investigated the dynamic changes of the microbial community and biogenic amine content during the fermentation of the traditional soybean paste. The microbial diversity of soybean paste in different regions was analyzed by MiSeq sequencing technology. The results showed that Penicillium and Tetragenococcus were the dominant microorganisms responsible for the fermentation of soybean paste. Biogenic amine was found in the traditional soybean paste at different fermentation stages, putrescine, and tyramine were the mainly biogenic amines and their content increased with the extension of fermentation time. Serratia in the soybean paste was positively correlated with the formation of spermine, cadaverine (p < .01), and β‐phenethylamine (p < .05), Leuconostoc was negatively correlated with tyramine formation (p < .05), and Enterococcus was positively correlated with the formation of histamine, tryptamine and cadaverine (p < .01). Lactobacillus fermentum HM22, Lactobacillus plantarum HM24, and Enterococcus faecalis YF10042 with strong biogenic amine degrading capacity were inoculated into the koji. After 20 days of fermentation, the degradation rates of tryptamine, β‐phenylethylamine, putrescine, cadaverine, histamine, and tyramine in soybean paste inoculated with L. plantarum HM24 were 35.31%, 43.14%, 30.18%, 33.44%, 32.74%, and 39.91%, respectively, indicating that the use of L. plantarum HM24 as a starter culture in soybean paste fermentation might be a good strategy for biogenic amines reduction.
Antioxidant and protective effects of extra virgin olive oil incorporated with diallyl sulfide against CCl4‐induced acute liver injury in mice
Authors: Habibi Emna , Baâti Tarek , Njim Leila , M’Rabet Yassine , Hosni Karim 
Published: October 2021

AbstractThe present study delineates the effects of incorporation of 1% diallyl sulfide (DAS) into extra virgin olive oil (EVOO) on the physico‐chemical characteristics, in vitro antioxidant, and in vivo hepatoprotective properties in CCl4‐induced acute liver injury in mice. Results showed that the DAS‐rich EVOO exhibited good oxidative stability over one‐month storage and preserved its original quality‐related parameters including major components (oleic acid, linoleic acid, and palmitic acid), and minor components (tocopherols, chlorophylls and carotenoids, tyrosol, hydroxytyrosol, elenolic acid, oleuropein and its aglycone, pinoresinol, vanilic acid, cinnamic acid, ferulic acid, luteolin, apigenin, and sterols). Compared with EVOO or DAS, the DAS‐rich EVOO displayed the highest DPPH and ABTS‐radical scavenging activities and showed the strongest cellular antioxidant activity (CAA). In connection with its free radical scavenging activity and CAA, DAS‐rich EVOO significantly normalized the serum ALT and AST levels and prevented the increase in interleukin‐6 in CCl4‐intoxicated mice. The manifest anti‐inflammatory and hepatoprotective effects of DAS‐rich EVOO were further supported by liver histopathological examinations. Overall, the EVOO enrichment with DAS could open up opportunities for the development of novel functional food with improved antioxidant and hepatoprotective properties.
Cerebral perfusion mediated by thalamo‐cortical functional connectivity in non‐dominant thalamus affects naming ability in aphasia
Authors: Zhang Jie , Zhou Zhen , Li Lingling , Ye Jing , Shang Desheng , Zhong Shuchang , Yao Bo , Xu Cong , Yu Yamei , He Fangping , Ye Xiangming , Luo Benyan 
Published: October 2021

AbstractNaming is a commonly impaired language domain in various types of aphasia. Emerging evidence supports the cortico‐subcortical circuitry subserving naming processing, although neurovascular regulation of the non‐dominant thalamic and basal ganglia subregions underlying post‐stroke naming difficulty remains unclear. Data from 25 subacute stroke patients and 26 age‐, sex‐, and education‐matched healthy volunteers were analyzed. Region‐of‐interest‐wise functional connectivity (FC) was calculated to measure the strength of cortico‐subcortical connections. Cerebral blood flow (CBF) was determined to reflect perfusion levels. Correlation and mediation analyses were performed to identify the relationship between cortico‐subcortical connectivity, regional cerebral perfusion, and naming performance. We observed increased right‐hemispheric subcortical connectivity in patients. FC between the right posterior superior temporal sulcus (pSTS) and lateral/medial prefrontal thalamus (lPFtha/mPFtha) exhibited significantly negative correlations with total naming score. Trend‐level increased CBF in subcortical nuclei, including that in the right lPFtha, and significant negative correlations between naming and regional perfusion of the right lPFtha were observed. The relationship between CBF in the right lPFtha and naming was fully mediated by the lPFtha‐pSTS connectivity in the non‐dominant hemisphere. Our findings suggest that perfusion changes in the right thalamic subregions affect naming performance through thalamo‐cortical circuits in post‐stroke aphasia. This study highlights the neurovascular pathophysiology of the non‐dominant hemisphere and demonstrates thalamic involvement in naming after stroke.
Perceived self‐efficacy of students and its influence on attitudes and knowledge about HIV/AIDS in Ghana
Authors: Opoku Maxwell Peprah , Agyei‐Okyere Elvis , Nketsia William , Torgbenu Eric Lawer , Kumi Emmanuel Opoku 
Published: October 2021

AbstractGlobally, human immunodeficiency syndrome (HIV) and its accompanying acquired immune deficiency syndrome (AIDS) have long been a public health threat due to the high death toll and the various effects on individuals and societies. Unfortunately, in developing countries such as Ghana, persons living with HIV/AIDS are victims of discrimination and rejection and are often excluded from social activities. Consequently, there is a need for mitigation strategies aimed at reducing the spread of the disease. Indeed, in human society, beliefs are fundamental to understanding people's intentions towards a given phenomenon. The purpose of this study was to assess students' perceived self‐efficacy, attitude towards and knowledge about HIV/AIDS. In this study, Bandura's self‐efficacy theory was used as a framework to assess the relationship between students' perceived self‐efficacy, attitude towards and knowledge about HIV/AIDS. A total of 342 students of at least 15 years old were recruited from junior and senior high schools and a public university to complete two scales: the general self‐efficacy and attitude and knowledge about HIV/AIDS scales. While there was a positive correlation among self‐efficacy, attitude and knowledge, attitude and knowledge combined to predict self‐efficacy. The limitations of the study, recommendations for future research and policy implications are discussed herein.
Two‐phase fluid motion through porous medium with volume fraction: An application of MATLAB bvp4c solver technique
Authors: Dey Debasish , Chutia Barbie 
Published: October 2021

AbstractIn this paper, we have attempted to study the steady two‐dimensional hydromagnetic convective flow through porous medium and heat transfer effects. Fluid is containing dust particles and is moving under the influence of Lorentz, buoyancy, Darcy, and viscous forces. Motion is considered to be governed by the volume fraction of the dust grains and the increment of shear stress and rate of heat transfer at the surface has been analyzed. Governing equations of the problem are converted into ordinary differential equations utilizing similarity transformations. The converted differential equations are figured numerically using the MATLAB built‐in technique bvp4c. The results are depicted in graphical forms for different values of the flow parameters. The findings are obtained considering the volume fraction and compared with the results of the previous paper. It is observed that the shear stress enhances with diminishing resistance and decreases for the higher values of the Hartmann number, permeability parameter, and volume fraction of the dust phase. Also, improving the Nusselt number gives a boost to thermal diffusivity.
Using micro‐catchment experiments for multi‐local scale modelling of nature‐based solutions
Authors: Hankin Barry , Page Trevor J. C. , Chappell Nick A. , Beven Keith J. , Smith Paul J. , Kretzschmar Ann , Lamb Rob 
Published: October 2021

AbstractThe Q‐natural flood management project has co‐developed with the Environment Agency 18 monitored micro‐catchments (~1 km2) in Cumbria, UK installing calibrated flumes aimed at quantifying the potential shift in observed flows resulting from a range of nature‐based‐solutions installed by local organizations. The small‐scale reduces the influence of variability characterizing larger catchments that would otherwise mask any such shifts, which we attempt to relate to a shift in model parameters. This paper demonstrates an approach to applying donor‐parameter‐shifts obtained from modelling two of the paired micro‐catchments to a much larger scale, in order to understand the potential for improved distributed modelling of nature‐based solutions in the form of additional tree‐planting. The models include a rainfall‐runoff model, Dynamic Topmodel, and a 2D hydrodynamic model, JFlow, permitting analysis of changes in hillslope processes and channel hydrodynamics resulting from a range of distributed measures designed to emulate natural hydrological processes that evaporate, store or infiltrate flows. We report on attempts to detect shift in hydrological response using one of the paired‐micro‐catchment moorland versus forestry sites in Lorton using Dynamic Topmodel. A donor‐parameter‐shift approach is used in a hypothetical experiment to represent new woodland in a much larger catchment, although testing all combinations of spatial planting strategies, responses to multiple‐extremes, failure‐modes and changes to synchronization becomes intractable to support good decision making. We argue that the problem can be re‐framed to use donor‐parameter‐shifts at multi‐local‐scale catchments above communities known to be at risk, commensurate with most of the evidence of NbS impacts being effective at the small scale (ca. 10 km2). This might lead to more effective modelling to help catchment managers prioritize those communities‐at‐risk where there is more evidence that NbS might be effective.
Accuracy and precision of the cosmic‐ray neutron sensor for soil moisture estimation at humid environments
Authors: Iwema Joost , Schrön Martin , Koltermann Da Silva Juliana , Schweiser De Paiva Lopes Rodolfo , Rosolem Rafael 
Published: October 2021

AbstractThe accuracy and precision of the cosmic‐ray neutron sensor (CRNS) neutron count and soil moisture estimate are affected differently by distinct neutron moderating factors. Moreover, whereas the accuracy can be improved by correcting for different hydrogen pools, the precision can only be improved by increasing the surface area of the CRNS sensors or by increasing the integration time. To date, the effects of different neutron moderating factors on CRNS accuracy and precision are not completely understood. We used data from three agricultural and low biomass sites located within a few kilometres distance from each other in South England. We developed an extended version of the COsmic‐ray Soil Moisture Interaction Code (COSMIC), which included the effects of relevant neutron moderating factors on the neutron counts. With sensitivity analysis, we found atmospheric pressure and soil moisture content to be most influential on neutron count accuracy and precision. These two factors were, respectively, seven and four times more important than soil bulk density, lattice water and soil organic matter. Above ground biomass was substantially less influential compared to these variables. However, because the three sites had similar soil organic matter and meteorology, calibration results showed that differences between sites could be mostly explained by differences in above ground biomass and to a lesser extent intercepted water. The neutron count differences due to above ground biomass corresponded with substantial soil moisture estimate differences up to ; a significant effect on soil moisture accuracy. The precision of the soil moisture estimate was 10 times more sensitive to soil moisture than other factors and was therefore mostly a function of soil moisture content itself. The neutron count integration times required to obtain a soil moisture precision were typically less than a day. Our results are indicative for other humid, temperate, agricultural sites.
Critically Reading the Canon: Culturally Sustaining Approaches to a Prescribed Literature Curriculum
Authors: Ervin Jennifer 
Published: October 2021

AbstractCulturally sustaining pedagogy (Paris, 2012) has emerged as an essential way to value the evolution of culture among diverse learners. Discussions around teaching in a culturally sustaining manner in the English language arts classroom, specifically when teaching literary analysis, often address the need to incorporate multicultural literature so that students are exposed to stories told from diverse perspectives. However, the reality in many schools is that teachers do not have ownership over their curriculum in a way that allows them to choose which texts they read and study with students. In this context, culturally sustaining teaching presents a difficult challenge. In this literature review, the author presents classroom strategies that apply a critical literacy lens to analysis of canonical literature as a way to create a place for culturally sustaining teaching within a prescribed curriculum.
CEO ownership and firm performance: Evidence from the 2003 dividend tax cut
Authors: Duong Hong Kim 
Published: October 2021

AbstractThis study investigates the performance consequences of changes in the optimality of chief executive officer (CEO) ownership by using the 2003 dividend tax cut (DTC) as an exogenous shock. I find that CEO ownership of dividend payers significantly increased after the DTC in the form of higher annual restricted stock grants and more option exercises. I also document that more optimal ownership is associated with performance improvement and more efficient R&D investment. Overall, findings from my study provide insights into the role of managerial equity incentives for firm performance.
STING‐mediated inflammation contributes to Gao binge ethanol feeding model
Authors: Wang Ling , You Hong‐Mei , Meng Hong‐Wu , Pan Xue‐Yin , Chen Xin , Bi Yi‐Hui , Zhang Ya‐Fei , Li Juan‐Juan , Yin Na‐Na , Zhang Zheng‐Wei , Huang Cheng , Li Jun 
Published: October 2021

AbstractAlcohol metabolism causes hepatocytes to release damage‐associated molecular patterns (DAMPs). This includes mitochondrial DNA (mtDNA), which is generated and released from damaged hepatocytes and contributes to liver injury by producing proinflammatory cytokines. STING is a pattern recognition receptor of DAMPs known to control the induction of innate immunity in various pathological processes. However, the expression profile and functions of STING in the Gao binge ethanol model remain poorly understood. We demonstrated that STING is upregulated in the Gao binge ethanol model. STING functions as an mtDNA sensor in the Kupffer cells of the liver and induces STING‐signaling pathway‐dependent inflammation and further aggravates hepatocyte apoptosis in the Gao binge ethanol model. This study provides novel insights into predicting disease progression and developing targeted therapies for alcoholic liver injury.
Role of miR‐185‐5p as modulator of periostin synthesis and smooth muscle contraction in asthma
Authors: Rodrigo‐Muñoz José M. , Cañas José A. , Sastre Beatriz , Gil‐Martínez Marta , García Latorre Raquel , Sastre Joaquín , del Pozo Victoria 
Published: October 2021

AbstractAsthma is a chronic respiratory disease produced by an aberrant immune response that originates with breathing difficulties and cough, through airway remodeling. The above pathophysiological events of asthma emerge the regulators of effectors, like epigenetics, which include microRNAs (miRNAs) who perform post‐transcriptional regulation, controlling diverse pathways in respiratory diseases. The objective of the study was to determine how miR‐185‐5p regulates the secretion of periostin by airway structural cells, and smooth muscle cells contraction, both related to airway remodeling in asthma. We used miR‐185‐5p mimic and inhibitors in bronchial smooth muscle cells (BSMCs) and small airway epithelial cells (SAECs) from healthy subjects. Gene expression and protein levels of periostin (POSTN), CDC42, and RHOA were analyzed by RT‐PCR and ELISA/Western blot, respectively. BSMC contractility was analyzed using cell‐embedded collagen gels and measurement of intracellular calcium was performed using Fura‐2. Additionally, miR‐185‐5p and periostin expression were evaluated in sputum from healthy and asthmatics. From these experiments, we observed that miR‐185‐5p modulation regulates periostin mRNA and protein in BSMCs and SAECs. A tendency for diminished miR‐185‐5p expression and higher periostin levels was seen in sputum cells from asthmatics compared to healthy, with an inverse correlation observed between POSTN and miR‐185‐5p. Inhibition of miR‐185‐5p produced higher BSMCs contraction induced by histamine. Calcium mobilization was not modified by miR‐185‐5p, showing that miR‐185‐5p role in BSMC contractility is performed by regulating CDC42 and RhoA pro‐contractile factors instead. In conclusion, miR‐185‐5p is a modulator of periostin secretion by airway structural cells and of smooth muscle contraction, which can be related to asthma pathophysiology, and thus, might be a promising therapeutic target.
Population Pharmacokinetics of Ponatinib in Healthy Adult Volunteers and Patients With Hematologic Malignancies and Model‐Informed Dose Selection for Pediatric Development
Authors: Hanley Michael J. , Diderichsen Paul M. , Narasimhan Narayana , Srivastava Shouryadeep , Gupta Neeraj , Venkatakrishnan Karthik 
Published: October 2021

AbstractThe BCR‐ABL1 inhibitor ponatinib is approved for the treatment of adults with chronic myeloid leukemia or Philadelphia chromosome–positive acute lymphoblastic leukemia, including those with the T315I mutation. We report a population pharmacokinetic model‐based analysis for ponatinib and its application to inform dose selection for pediatric development. Plasma concentration–time data were collected from 260 participants (86 healthy volunteers; 174 patients with hematologic malignancies) enrolled across 7 clinical trials. Data were analyzed using nonlinear mixed‐effects modeling. Ponatinib pharmacokinetics were described by a 2‐compartment model with first‐order elimination from the central compartment. The final model included body weight and age as covariates on the apparent central volume of distribution; however, exposure variability explained by these covariates was small compared with overall variability in the population. None of the covariates evaluated, including sex, age (19‐85 years), race, body weight (40.7‐152.0 kg), total bilirubin (0.1‐3.16 mg/dL), alanine aminotransferase (6‐188 U/L), albumin (23.0‐52.5 g/L), and creatinine clearance (≥28 mL/min) had clinically meaningful effects on apparent oral clearance. Simulations based on the final model predicted that daily doses of 15 to 45 mg result in steady‐state average concentrations that are in the pharmacological range for BCR‐ABL1 inhibition and approximate or exceed concentrations associated with suppression of T315I mutant clones. The final model was adapted using allometric scaling to inform dose selection for pediatric development. Clinicaltrials.gov identifier: NCT00660920; NCT01667133; NCT01650805