bluuebunny/crossref_metadata_2025_split huggingface dataset:
Political Science Scholarship on the Middle East: A View from the Journals
Authors: Cammett Melani , Kendall Isabel 
Published: February 2021

ABSTRACTBased on an original dataset of all articles on the Middle East in major political science journals during the past two decades, we assess trends in publishing on the region to explore whether it remains underrepresented in political science and how the field has evolved. We focus on the evolution of the total share of Middle East and North Africa (MENA)-focused articles, research topics, methods employed, and patterns of authorship by gender. The proportion of MENA-focused articles has increased, particularly after the 2011 Arab Spring uprisings, but remains strikingly low. With respect to topics and methods, research on the Middle East is increasingly integrated in mainstream political science, with articles addressing core disciplinary debates and relying increasingly more on statistical and experimental methods. Yet, these shifts may come at the expense of predominantly qualitative research, and primary topics may reflect the priorities of Western researchers while underplaying the major concerns of Middle Eastern publics.
Selling Orchestral Music in the Vaudeville Age: The Duncan-Damrosch Tours, 1908–1911
Authors: FRANKENBACH CHANTAL 
Published: February 2021

AbstractBetween 1908 and 1911, New York Symphony Orchestra conductor Walter Damrosch engaged the modern dancer Isadora Duncan to perform with his orchestra in New York and on three tours of the Midwest. Posing considerable risk to his reputation as an elite conductor, this unusual alliance grew in part from his concert manager's wish to compete with the Salomé dance craze raging in vaudeville halls across the country. Damrosch's “pioneering spirit” allowed him a genuine appreciation of Duncan's expressive, transcendent dancing. Yet for his critics, the shockingly under-dressed dancer, just back from her conquest of Europe, represented yet another sensational Salomé eager to capitalize on the popular profanities of market-driven entertainment. Music critics and Protestant clergymen from St. Louis to Boston berated Damrosch for what they saw as an immoral capitulation to mass consumerism and a desecrating abuse of the sacred repertoire he guarded—a repertoire defined in part by its distance from dancing. This article draws on critiques in the daily press, Damrosch's personal papers, and scholarship in dance and religious studies to situate Damrosch's marketing experiment with Duncan in the wider context of Progressive-era devotional life, where similar concessions to mass entertainment arose in the urban revival movement of the Third Great Awakening. Damrosch's recourse to Duncan's “barefoot dancing”—oddly akin to the tactics of big tent revivalists espousing Muscular Christianity and epitomized by Billy Sunday's pulpit pantomimes—illuminates the collision of spiritual and economic concerns that shaped both musical and ecclesiastical arenas of the American “sacred.”
Millimeter-wave dual-mode and dual-band switchable Gilbert up-conversion mixer in 65-nm CMOS process
Authors: Zhu Fang , Luo Guo Qing 
Published: February 2021

AbstractIn this paper, a millimeter-wave (MMW) dual-mode and dual-band switchable Gilbert up-conversion mixer in a commercial 65-nm complementary metal oxide semiconductor (CMOS) process is presented. By simply changing the bias, the proposed CMOS Gilbert up-conversion mixer can be switched between subharmonic and fundamental operation modes for MMW dual-band applications. With a low local oscillator pumping power of 3 dBm and low dc power consumption of 6 mW, the proposed CMOS Gilbert up-conversion mixer exhibits a measured conversion gain of −0.5 ± 1.5 dB from 37 to 50 GHz and 2.5 ± 1.5 dB from 17.5 to 32 GHz for the subharmonic and fundamental modes, respectively.
Implications of COVID-19 on progress in the UN Conventions on biodiversity and climate change
Authors: Ortiz Andrea Monica D. , de Leon Alaya M. , Torres Justine Nicole V. , Guiao Cecilia Therese T. , La Viña Antonio G. M. 
Published: February 2021

2020 was to be a landmark year for setting targets to stop biodiversity loss and prevent dangerous climate change. However, COVID-19 has caused delays to the 15th Conference of the Parties (COP) of the UN Convention on Biological Diversity and the 26th COP of the UN Framework Convention on Climate Change. Negotiations on the Global Biodiversity Framework and the second submission of Nationally Determined Contributions under the Paris Agreement were due to take place at these COPs. There is uncertainty as to how the COVID-19 disruption will affect the negotiations, whether parties will pursue more ambitious actions or take a weaker stance on issues. Our policy analysis shows there are broad opportunities for climate and biodiversity frameworks to better respond to COVID-19, by viewing future pandemics, biodiversity loss, and climate change as interconnected problems. Importantly, there needs to be greater focus on agriculture and food systems in discussions, establishing safeguards for carbon markets, and implementing nature-based solutions in meeting the Paris Agreement goals. We can no longer delay action to address the biodiversity and climate emergencies, and accelerating sustainable recovery plans through virtual spaces may help keep discussions and momentum before the resumption of in-person negotiations.Non-technical summary:High ambition needed at UN biodiversity and climate conferences to address pandemics, biodiversity, climate change, and health.
Scenarios of Human Responses to Unprecedented Social‐Environmental Extreme Events
Authors: Rusca Maria , Messori Gabriele , Di Baldassarre Giuliano 
Published: February 2021

AbstractIn a rapidly changing world, what is today an unprecedented extreme may soon become the norm. As a result, extreme‐related disasters are expected to become more frequent and intense. This will have widespread socio‐economic consequences and affect the ability of different societal groups to recover from and adapt to rapidly changing environmental conditions. Therefore, there is the need to decipher the relation between genesis of unprecedented events, accumulation and distribution of risk, and recovery trajectories across different societal groups. Here, we develop an analytical approach to unravel the complexity of future extremes and multiscalar societal responses—from households to national governments and from immediate impacts to longer term recovery. This requires creating new forms of knowledge that integrate analyses of the past—that is, structural causes and political processes of risk accumulation and differentiated recovery trajectories—with plausible scenarios of future environmental extremes grounded in the event‐specific literature. We specifically seek to combine the physical characteristics of the extremes with examinations of how culture, politics, power, and policy visions shape societal responses to unprecedented events, and interpret the events associal‐environmentalextremes. This new approach, at the nexus between social and natural sciences, has the concrete advantage of providing an impact‐focused vision of future social‐environmental risks, beyond what is achievable within conventional disciplinary boundaries. In this paper, we focus on extreme flooding events and the societal responses they elicit. However, our approach is flexible and applicable to a wide range of extreme events. We see it as the first building block of a new field of research, allowing for novel and integrated theoretical explanations and forecasting of social‐environmental extremes.
Effects of the IMF Direction on Atmospheric Escape From a Mars‐like Planet Under Weak Intrinsic Magnetic Field Conditions
Authors: Sakai Shotaro , Seki Kanako , Terada Naoki , Shinagawa Hiroyuki , Sakata Ryoya , Tanaka Takashi , Ebihara Yusuke 
Published: February 2021

AbstractDirection of the upstream interplanetary magnetic field (IMF) significantly changes the magnetospheric configuration, influencing the atmospheric escape mechanism. This paper investigates effects of IMF on the ion escape mechanism from a Mars‐like planet that has a weak dipole magnetic field directing northward on the equatorial surface. The northward (parallel to the dipole at subsolar), southward (antiparallel), and Parker‐spiral IMFs under present solar wind conditions are compared based on multispecies magnetohydrodynamics simulations. In the northward IMF case, molecular ions escape from the high‐latitude lobe reconnection region, where ionospheric ions are transported upward along open field lines. Atomic oxygen ions originating either in the ionosphere or oxygen corona escape through a broader ring‐shaped region. In the southward IMF case, the escape flux of heavy ions increases significantly and has peaks around the equatorial dawn and dusk flanks. The draped IMF can penetrate into the subsolar ionosphere by erosion, and the IMF becomes mass‐loaded as it is transported through the dayside ionosphere. The mass‐loaded draped IMF is carried to the tail, contributing to ion escape. The escape channels in the northward and southward IMF cases are different from those in the Parker‐spiral IMF case. The escape rate is the lowest in the northward IMF case and comparable in the Parker‐spiral and southward IMF cases. In the northward IMF case, a weak intrinsic dipole forms a magnetosphere configuration similar to that of Earth, quenching the escape rate, while the Parker‐spiral and southward IMFs cause reconnection and erosion, promoting ion escape from the upper atmosphere.
Data‐Driven Two‐Fault Modeling of the Mw 6.0 2008 Wells, Nevada Earthquake Suggests a Listric Fault Rupture
Authors: Frietsch Michael , Ferreira Ana M. G. , Funning Gareth J. 
Published: February 2021

AbstractStructural fault complexity at depth affects seismic hazard, earthquake physics, and regional tectonic behavior, but constraining such complexity is challenging. We present earthquake source models of the February 21, 2008, Mw 6.0 Wells event that occurred in the Basin and Range in the western USA, suggesting the rupture of both the shallow and deep parts of a listric fault. We use a large data set including 150 local seismic waveforms from the USArray combined with high‐quality Interferometric Synthetic Aperture Radar and teleseismic waveforms. Rather than imposing an a priori fault geometry in the source inversions, as is often done in the literature, we use a data‐driven approach whereby all the faulting parameters and number of faults are determined by the data alone. We find a two‐fault normal faulting solution comprising: (i) a shallow (centroid depth ∼4.6 km) sub‐event with Mw 5.3 and fault dip of ∼77°; and (ii) a deeper (centroid depth ∼8.8 km), larger Mw 6.0 sub‐event on a fault with shallower dip angle (∼41°). Our preferred two‐fault model is consistent with aftershocks and with the tectonics of the region. The local USArray waveforms used in the modeling are key to detect the rupture of both shallow and deep parts of the possible listric fault. The lack of such dense and uniform coverage of earthquakes in other regions on Earth may explain why the full seismic rupture of listric faults may have gone undetected in the past. Thus, earthquake slip on whole listric faults may be more common than previously thought.
Targeting tumor-associated macrophages to synergize tumor immunotherapy
Authors: Xiang Xiaonan , Wang Jianguo , Lu Di , Xu Xiao 
Published: February 2021

AbstractThe current treatment strategies in advanced malignancies remain limited. Notably, immunotherapies have raised hope for a successful control of these advanced diseases, but their therapeutic responses are suboptimal and vary considerably among individuals. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment (TME) and are often correlated with poor prognosis and therapy resistance, including immunotherapies. Thus, a deeper understanding of the complex roles of TAMs in immunotherapy regulation could provide new insight into the TME. Furthermore, targeting of TAMs is an emerging field of interest due to the hope that these strategies will synergize with current immunotherapies. In this review, we summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies, and discuss the therapeutic potential of targeting TAMs as an adjuvant therapy in tumor immunotherapies.
Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years
Authors: Passweg Jakob R. , Baldomero Helen , Chabannon Christian , Basak Grzegorz W. , de la Cámara Rafael , Corbacioglu Selim , Dolstra Harry , Duarte Rafael , Glass Bertram , Greco Raffaella , Lankester Arjan C. , Mohty Mohamad , Peffault de Latour Régis , Snowden John A. , Yakoub-Agha Ibrahim , Kröger Nicolaus ,   for the European Society for Blood and Marrow Transplantation (EBMT)
Published: February 2021

AbstractNumbers of Hematopoietic cell transplantation (HCT) in Europe and collaborating countries continues to rise with 48,512 HCT in 43,581 patients, comprising of 19,798 (41%) allogeneic and 28,714 (59%) autologous, reported by 700 centers in 51 countries during 2019. Main indications were myeloid malignancies 10,764 (25%), lymphoid malignancies 27,895 (64%), and nonmalignant disorders 3173 (7%). A marked growth in CAR-T cellular therapies from 151 in 2017 to 1134 patients in 2019 is observed. This year’s analyses focus on changes over 30 years. Since the first survey in 1990 where 143 centers reported 4234 HCT, the number has increased to 700 centers and 48,512 HCT. Transplants were reported in 20 countries in 1990, and 51, 30 years later. More than 800,000 HCT in 715,000 patients were reported overall. Next to the massive expansion of HCT technology, most notable developments include the success of unrelated donor and haploidentical HCT, an increase followed by decrease in the number of cord blood transplants, use of reduced intensity HCT in older patients, and the phenomenal rise in cellular therapy. This annual report of the European Society for Blood and Marrow Transplantation (EBMT) reflects current activity and highlights important trends vital for health care planning.
Detector-integrated on-chip QKD receiver for GHz clock rates
Authors: Beutel Fabian , Gehring Helge , Wolff Martin A. , Schuck Carsten , Pernice Wolfram 
Published: February 2021

AbstractQuantum key distribution (QKD) can greatly benefit from photonic integration, which enables implementing low-loss, alignment-free, and scalable photonic circuitry. At the same time, superconducting nanowire single-photon detectors (SNSPD) are an ideal detector technology for QKD due to their high efficiency, low dark-count rate, and low jitter. We present a QKD receiver chip featuring the full photonic circuitry needed for different time-based protocols, including single-photon detectors. By utilizing waveguide-integrated SNSPDs we achieve low dead times together with low dark-count rates and demonstrate a QKD experiment at 2.6 GHz clock rate, yielding secret-key rates of 2.5 Mbit/s for low channel attenuations of 2.5 dB without detector saturation. Due to the broadband 3D polymer couplers the reciver chip can be operated at a wide wavelength range in the telecom band, thus paving the way for highly parallelized wavelength-division multiplexing implementations.
The transferability of handwriting skills: from the Cyrillic to the Latin alphabet
Authors: Asselborn Thibault , Johal Wafa , Tleubayev Bolat , Zhexenova Zhanel , Dillenbourg Pierre , McBride Catherine , Sandygulova Anara 
Published: February 2021

AbstractDo handwriting skills transfer when a child writes in two different scripts, such as the Latin and Cyrillic alphabets? Are our measures of handwriting skills intrinsically bound to one alphabet or will a child who faces handwriting difficulties in one script experience similar difficulties in the other script? To answer these questions, 190 children from grades 1–4 were asked to copy a short text using both the Cyrillic and Latin alphabets on a digital tablet. A recent change of policy in Kazakhstan gave us an opportunity to measure transfer, as the Latin-based Kazakh alphabet has not yet been introduced. Therefore, pupils in grade 1 had a 6-months experience in Cyrillic, and pupils in grades 2, 3, and 4 had 1.5, 2.5, and 3.5 years of experience in Cyrillic, respectively. This unique situation created a quasi-experimental situation that allowed us to measure the influence of the number of years spent practicing Cyrillic on the quality of handwriting in the Latin alphabet. The results showed that some of the differences between the two scripts were constant across all grades. These differences thus reflect the intrinsic differences in the handwriting dynamics between the two alphabets. For instance, several features related to the pen pressure on the tablet are quite different. Other features, however, revealed decreasing differences between the two scripts across grades. While we found that the quality of Cyrillic writing increased from grades 1–4, due to increased practice, we also found that the quality of the Latin writing increased as well, despite the fact that all of the pupils had the same absence of experience in writing in Latin. We can therefore interpret this improvement in Latin script as an indicator of the transfer of fine motor control skills from Cyrillic to Latin. This result is especially surprising given that one could instead hypothesize a negative transfer, i.e., that the finger controls automated for one alphabet would interfere with those required by the other alphabet. One interesting side-effect of these findings is that the algorithms that we developed for the diagnosis of handwriting difficulties among French-speaking children could be relevant for other alphabets, paving the way for the creation of a cross-lingual model for the detection of handwriting difficulties.
Endogenous complement human serum bactericidal assay (enc-hSBA) for vaccine effectiveness assessments against meningococcal serogroup B
Authors: Kleinschmidt Annett , Vadivelu Kumaran , Serino Laura , Neidig Nina , de Wergifosse Bertrand 
Published: February 2021

AbstractImmunogenicity of vaccines against meningococcal serogroup B (MenB) has been assessed pre-licensure with a human serum bactericidal activity assay (hSBA), tested against small numbers of strains. We report the qualification/validation of an alternative qualitative hSBA which uses endogenous complement (enc-hSBA) present in the vaccinee’s serum. Serum samples were collected from adults pre-vaccination and post-vaccination with the 4-component MenB vaccine (4CMenB). A representative panel of invasive isolates and 4 antigen-specific indicator strains were used in qualification experiments. Each strain was tested in ≥3 experiments with pre/post-vaccination sera to evaluate intermediate precision. A 110-strain panel and the 4 indicator strains met qualification criteria, demonstrating assay precision. Assay robustness, specificity and sensitivity were demonstrated using the 4 indicator strains. Enc-hSBA is highly standardized, allows testing across large panels of epidemiologically-relevant MenB strains, and accounts for complement activity differences between vaccinees. Therefore, enc-hSBA enables a more accurate estimation of effectiveness for vaccines against MenB.
High diversity droplet microfluidic libraries generated with a commercial liquid spotter
Authors: Zhang Jesse Q. , Siltanen Christian A. , Dolatmoradi Ata , Sun Chen , Chang Kai-Chun , Cole Russell H. , Gartner Zev J. , Abate Adam R. 
Published: February 2021

AbstractDroplet libraries consisting of many reagents encapsulated in separate droplets are necessary for applications of microfluidics, including combinatorial chemical synthesis, DNA-encoded libraries, and massively multiplexed PCR. However, existing approaches for generating them are laborious and impractical. Here, we describe an automated approach using a commercial array spotter. The approach can controllably emulsify hundreds of different reagents in a fraction of the time of manual operation of a microfluidic device, and without any user intervention. We demonstrate that the droplets produced by the spotter are similarly uniform to those produced by microfluidics and automate the generation of a ~ 2 mL emulsion containing 192 different reagents in ~ 4 h. The ease with which it can generate high diversity droplet libraries should make combinatorial applications more feasible in droplet microfluidics. Moreover, the instrument serves as an automated droplet generator, allowing execution of droplet reactions without microfluidic expertise.
Automatic segmentation of inner ear on CT-scan using auto-context convolutional neural network
Authors: Hussain Raabid , Lalande Alain , Girum Kibrom Berihu , Guigou Caroline , Bozorg Grayeli Alexis 
Published: February 2021

AbstractTemporal bone CT-scan is a prerequisite in most surgical procedures concerning the ear such as cochlear implants. The 3D vision of inner ear structures is crucial for diagnostic and surgical preplanning purposes. Since clinical CT-scans are acquired at relatively low resolutions, improved performance can be achieved by registering patient-specific CT images to a high-resolution inner ear model built from accurate 3D segmentations based on micro-CT of human temporal bone specimens. This paper presents a framework based on convolutional neural network for human inner ear segmentation from micro-CT images which can be used to build such a model from an extensive database. The proposed approach employs an auto-context based cascaded 2D U-net architecture with 3D connected component refinement to segment the cochlear scalae, semicircular canals, and the vestibule. The system was formulated on a data set composed of 17 micro-CT from public Hear-EU dataset. A Dice coefficient of 0.90 and Hausdorff distance of 0.74 mm were obtained. The system yielded precise and fast automatic inner-ear segmentations.
Electron–phonon coupling in superconducting 1T-PdTe2
Authors: Anemone Gloria , Casado Aguilar Pablo , Garnica Manuela , Calleja Fabian , Al Taleb Amjad , Kuo Chia-Nung , Lue Chin Shan , Politano Antonio , Vázquez de Parga Amadeo L. , Benedek Giorgio , Farías Daniel , Miranda Rodolfo 
Published: February 2021

AbstractWe have determined the electron–phonon interaction in type II Dirac semimetallic 1T-PdTe2 by means of helium atom scattering. While 1T-PdTe2 is isostructural with 1T-PtTe2, only the former is superconductor. The difference can be traced to the substantially larger value of the electron–phonon coupling in 1T-PdTe2, λ = 0.58, obtained from the Debye-Waller attenuation of the He specular peak. With this value and the surface Debye temperature, ΘD = 106.2 K, we have figured out the superconducting critical temperature, Tc = 1.83 K given by the BCS theory, which is in good agreement with Tc = (1.95 ± 0.03) K obtained with low-temperature scanning tunneling microscopy. The value of the effective mass related to ΘD indicates that the large electron–phonon coupling in 1T-PdTe2 is due to coupling, not only with the zone-center optical mode O2 at 9.2 meV, as proposed in a recent theoretical study, but also with the zone-boundary acoustic mode LA. Our results suggest that the topological states of a Dirac cone play a negligible role on the onset of superconductivity.