bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Performance Optimization of Manganese‐based Cathode Materials for Zinc‐Ion Batteries
Authors: Wang Song , Sang Zhiyuan , Zhao Xinqi , Guo Jingdong , Chen Hao , Yang De'an 
Published: December 2021

AbstractOwing to the low cost, high specific capacity and high safety, zinc‐ion batteries (ZIBs) have great advantages in replacing lithium‐ion batteries to meet future demand for energy storage. Manganese‐based cathode materials, benefiting from the abundant reserves, non‐toxic, acceptable capacity and long cycle stability, have been widely developed and applied to develop high performance ZIBs. Unfortunately, poor conductivity, Mn2+ dissolution and unstable structure hinder it to achieve an ideal electrochemical performance. Thus, an overview of the cathodic performance optimization strategies and the synthesis is provided. Firstly, the synthesis methods and their influence on the morphology and structure are summarized. Secondly, various strategies of performance optimization, including structure design, compositing with conductive materials, pre‐intercalation, defect engineering and electrochemical activation, are categorized and analyzed in detail. Lastly, perspectives on the subsequent performance optimization are proposed. It is expected that this review will be beneficial to future scientific research on tailoring manganese‐based cathode materials for ZIBs.
Current‐Corrected Cycling Strategies for True Electrode Performance Measurement
Authors: Yan Zilai , Scott Benjamin , Glazier Stephen L. , Obrovac Mark N. 
Published: December 2021

AbstractIn battery research, galvanostatic cycling is the most widely used strategy to evaluate electrode performance. By applying pre‐set current throughout the test, this method often fails to accurately reflect electrode performance at the designed cycling rate (particularly for high‐rate cycling) because the actual capacity can be considerably affected by polarization and electrode degradation. To address this issue, a current‐corrected cycling method is proposed, in which the current is actively adjusted during cycling based on the measured capacity of previous cycles. Compared to the traditional method, which may result in cycling rates that are hundreds of times faster than the designed rate, the proposed cycling strategy can effectively measure rate‐dependent electrode performance precisely at designated rates. The authors believe this method is highly useful in electrode/battery performance evaluation for practical cell design, particularly in fast‐charging applications.
Crocin attenuates inflammation of lung tissue in ovalbumin‐sensitized mice by altering the expression of endoplasmic reticulum stress markers
Authors: Aslani Mohammad Reza , Amani Mojtaba , Masrori Neghin , Boskabady Mohammad Hossein , Ebrahimi Hossein Ali , Chodari Leila 
Published: December 2021

AbstractEndoplasmic reticulum (ER) stress plays a pivotal role in the pathogenesis of asthma. The present study aimed to investigate the reducing or suppressing effects of crocin in ovalbumin (OVA)‐sensitized mice on ER stress markers. Mice were divided into six groups (n = 5 per group) including control, OVA‐sensitized (OVA), OVA‐treated crocin (OVA‐Cr25, OVA‐Cr50, and OVA‐Cr100 mg/kg), and OVA‐treated dexamethasone (1 mg/kg), (OVA‐Dexa) groups. Animals 5 later groups were sensitized to OVA and the treatment groups received intraperitoneally crocin/dexamethasone in the last 5 days of the model. At the end of the study, lung tissue was evaluated for airway inflammation, caspase 12 and CHOP protein levels, and expression of ER stress markers using real‐time‐PCR. Sensitization with OVA significantly caused airway inflammation and induction of ER stress in mice compared to the control group based on the elevated inflammatory cells and ER stress markers in the lung tissue. Treatment with crocin and dexamethasone reduced airway inflammation and suppressed ER stress markers. Interestingly, in the OVA‐Cr100 group, the suppressive effects on ER stress apoptotic markers were comparable to the OVA‐Dexa group. The results suggest that crocin mediates maladaptive ER stress conditions possibly by creating adaptive ER stress status and driving protein folding correctly.
Identification of anti–hepatic fibrosis components in Periplaneta americana based on spectrum–effect relationship and chemical component separation
Authors: Fu Wenpeng , Zhao Yanwen , Xie Jingjing , Yang Yongshou , Xiao Peiyun 
Published: November 2021

AbstractPeriplaneta americana (PA) is used as a traditional medicine for hepatic diseases such as hepatic fibrosis in China. However, the relationship between the corresponding therapeutic effect and the chemical composition is still unclear. In this study, spectrum–effect relationship and chemical component separation were used to discover the potential of anti–hepatic fibrosis components of PA. The fingerprints of 10 batches of samples were established using HPLC, and the anti–hepatic fibrosis effect was determined using HSC‐T6 cells. The spectrum–effect relationship between common peaks and efficacy values was established using partial least squares analysis. Partial peaks in the fingerprints were identified, including X4 (9,12‐heptadecanedenoic acid glyceride), X5 (nonadecanoic acid methyl ester), X6 (glyceryl oleate), X7 (13,16,19‐eicosatrienoic acid), X9 (linoleic acid), X10 (9,12,15‐octadecatrienoic acid glyceride), X12 (hexadecanoic acid), X13 (oleic acid), and X14 (octadecanoic acid), and their anti–hepatic fibrosis activity was tested to verify the results of spectrum–effect relationships. The results showed that X4, X6, X7, and X10 were the active ingredients of PA. This work successfully identified the partial anti–hepatic fibrosis components of PA, which can be used to explain the material basis for the PA anti–hepatic fibrosis effect.
Establishment and validation of an SIL‐IS LC–MS/MS method for the determination of ibuprofen in human plasma and its pharmacokinetic study
Authors: Wang Changmao , Wang Yaqin , Xie Haitang , Zhan Cuijiao , He Xuejun , Liu Ran , Hu Rongfeng , Shen Jie , Jia Yuanwei 
Published: November 2021

AbstractIn this work, we developed and validated a highly sensitive, rapid and stable LC–MS/MS method for the determination of ibuprofen in human plasma with ibuprofen‐d3 as a stable isotopically labeled internal standard (SIL‐IS). Human plasma samples were prepared by one‐step protein precipitation. The chromatographic separation was achieved on a Poroshell 120 EC‐C18 (2.1 × 50 mm, 2.7 μm). Aqueous solution (containing 0.05% acetic acid and 5 mm NH4Ac) and methanol were selected as the mobile phase with gradient elution. An electrospray ionization source was applied and operated in negative ion mode. Multiple reaction monitoring mode was used for quantification using target fragment ions m/z 205.0 → 161.1 for ibuprofen and m/z 208.0 → 164.0 for SIL‐IS, respectively. This method exhibited a linear range of 0.05–36 μg/ml for ibuprofen with correlation coefficient >0.99. Mean recoveries of ibuprofen in human plasma ranged from 78.4 to 80.9%. The RSD of intra‐ and inter‐day precision were both < 5%. The accuracy was between 88.2 and 103.67%. The matrix effect was negligible in human plasma, including lipidemia and hemolytic plasma. A simple, efficient and accurate LC–MS/MS method was successfully established and applied to a pharmacokinetic study in healthy Chinese volunteers after a single oral administration of ibuprofen granules.
The association between coracoacromial ligament morphology and rotator cuff tears: A cadaveric study
Authors: Alraddadi Abdulrahman , Alashkham Abduelmenem , Lamb Clare , Soames Roger 
Published: December 2021

AbstractTo determine the association between coracoacromial ligament (CAL) morphology and rotator cuff tears. The present study is a prospective cohort study based on the dissection of 172 shoulders from 86 (46 female, 40 male) formalin embalmed European Caucasian cadavers, with a median age of 82 years. The anatomy of CAL was examined, including its morphology and parametric measurements, while the rotator cuff tendons were inspected for the presence of tears. Gross examination of the CAL in 155 shoulders revealed a variable number of bands as follows: 28 (18%) had one band, 56 (36%) two bands and 71 (46%) three or more bands. Inspection of the rotator cuff tendons showed the presence of tears in 77 (50%) shoulders, of which 37 (24%) were partial and 40 (26%) were full‐thickness tears. Statistical analysis showed a significant association (P < 0.05) between CAL band number and the prevalence of a rotator cuff tear. A high proportion of rotator cuff tears were observed in shoulders with two (52%) and three or more CAL bands (56%) compared to single band ligaments (29%). Parametric assessment of the CAL in shoulders with rotator cuff tears showed significantly greater (P < 0.05) attachment widths and ratios, thicker ligament bands, and larger cross‐sectional areas compared to the control group. Coracoacromial ligaments with more than a single band have a strong association with rotator cuff tears.
Lithium Storage Properties of TiC‐Modified SnS2 Nanosheets
Authors: Ren Ying , Shi Qi , Zhang Guifeng 
Published: December 2021

AbstractTo deal with the problem of low conductivity and easy restacking of SnS2 nanosheets, TiC‐modified SnS2 nanosheets have been obtained by sulfurization of Sn/TiC precursors. Electrochemical test results show that a synergistic effect of ultrathin SnS2 nanosheets and highly conductive TiC can significantly improve the lithium storage properties of the nanocomposite. The higher the TiC content in the SnS2/TiC nanosheets, the greater their capacity. More specifically, an SnS2/TiC (35 %) electrode delivers a high reversible capacity of 631 mAh g−1 at 0.3 A g−1 after 100 cycles, corresponding to a capacity retention of 87.0 %. Moreover, it exhibits a higher surface area of 50.076 m2 g−1 and outstanding cyclability with a reversible capacity of 597 mAh g−1 at 1 A g−1 after 350 cycles. Overall SnS2/TiC nanosheets have high yield and purity, and their preparation is simple, making them an ideal candidate material for high‐performance anodes in next‐generation Li‐ion batteries.
Ruthenium Complexes Bearing Axially Chiral Bipyridyls: The Mismatched Diastereomer Showed Red Circularly Polarized Phosphorescence
Authors: Takaishi Kazuto , Nakatsuka Yusuke , Asano Hitomi , Yamada Yuya , Ema Tadashi 
Published: November 2021

AbstractRutheniumII complexes bearing three axially chiral bipyridyl ligands were synthesized as a new family of chiral complex dyes, and Δ‐(S)‐ and Λ‐(S)‐diastereomers were obtained. The X‐ray crystal structure analyses, spectroscopy, and DFT calculations suggested that all the bipyridyls maintained chirality in both the ground and excited states, and the Δ‐(S)‐ and Λ‐(S)‐isomers are the matched (more relaxed) and mismatched (more constrained) pairs, respectively. The mismatched Λ‐(S)‐isomer exhibited red circularly polarized phosphorescence (CPP) both in solution and in the solid state. The solution state CPP is the most intense of ruthenium complexes, while the solid state CPP is the first example of them. It is supposed that, for the Λ‐(S)‐isomer, the six cumulative CH/π interactions suppress further distortion in the T1 state.
Ultrafiltration and cardiopulmonary bypass associated acute kidney injury: A systematic review and meta‐analysis
Authors: Kandil Omneya A. , Motawea Karam R. , Darling Edward , Riley Jeffrey B. , Shah Jaffer , Elashhat Mohamed Abdalla Mohamed , Searles Bruce , Aiash Hani 
Published: November 2021

AbstractBackgroundCardiopulmonary bypass is known to raise the risk of acute kidney injury (AKI). Previous studies have identified numerous risk factors of cardiopulmonary bypass including the possible impact of perioperative ultrafiltration. However, the association between ultrafiltration (UF) and AKI remains conflicting. Thus, we conducted a meta‐analysis to further examine the relationship between UF and AKI.HypothesisUltrafiltration during cardiac surgery increases the risk of developping Acute kidney Injury.MethodsWe searched PubMed, Web of Science, EBSCO, and SCOPUS through July 2021. The RevMan (version 5.4) software was used to calculate the pooled risk ratios (RRs) and mean differences along with their associated confidence intervals (95% CI).ResultsWe identified 12 studies with a total of 8005 patients. There was no statistically significant difference in the incidence of AKI between the group who underwent UF and the control group who did not (RR = 0.90, 95% CI = 0.64−1). Subgroup analysis on patients with previous renal insufficiency also yielded nonsignificant difference (RR = 0.84, 95% CI = 0.53 −1.33, p = .47). Subgroup analysis based on volume of ultrafiltrate removed (> or <2900 ml) was not significant and did not increase the AKI risk as predicted (RR = 0.82, 95% CI = 0.63 −1.07, p = .15). We also did subgroup analysis according to the type of UF and again no significant difference in AKI incidence between UF groups and controls was observed in either the conventional ultrafiltration (CUF), modified ultrafiltration (MUF), zero‐balanced ultrafiltration (ZBUF), or combined MUF and CUF subgroups.ConclusionUF in cardiac surgery is not associated with increased AKI incidence and may be safely used even in baseline chronic injury patients.
Metal‐Based Aggregation‐Induced Emission Theranostic Systems
Authors: Shen Hanchen , Xu Changhuo , Sun Feiyi , Zhao Mengying , Wu Qian , Zhang Jianyu , Li Sijie , Zhang Jing , Lam Jacky W. Y. , Tang Ben Zhong 
Published: November 2021

AbstractEfficient theranostic systems can realize better outcomes in disease treatment because of precise diagnosis and the concomitant effective therapy. Aggregation‐induced emission luminogens (AIEgens) are a unique type of organic emitters with intriguing photophysical properties in the aggregate state. Among the AIEgens studied for biomedical applications, so far, metal‐based AIE systems have shown great potential in theranostics due to the enhanced multimodal bioimaging ability and therapeutic effect. This research field has been growing rapidly, and many rationally designed systems with promising activities to cancer and other diseases have been reported recently. In this review, we summarized the recent progress of metal‐based AIE materials in bioimaging and biological theranostics, and deciphered the pertinent design strategies. We hope that this review can offer new insights into the development of this growing field.
Comparative Hydrophobic Core Dynamics Between Wild‐Type Amyloid‐β Fibrils, Glutamate‐3 Truncation, and Serine‐8 Phosphorylation
Authors: Vugmeyster Liliya , Fai Au Dan , Smith Matthew C. , Ostrovsky Dmitry 
Published: November 2021

AbstractPost‐translational modifications (PTMs) of amyloid‐β (Aβ) species are implicated in the modulation of overall toxicities and aggregation propensities. We investigated the internal dynamics in the hydrophobic core of the truncated ΔE3 mutant fibrils of Aβ1–40and compared them with prior and new data for wild‐type fibrils as well as with phosphorylated S8 fibrils. Deuteron static solid‐state NMR techniques, spanning line‐shape analysis, longitudinal relaxation, and chemical exchange saturation transfer methods, were employed to assess the rotameric jumps of several methyl‐bearing and aromatic groups in the core of the fibrils. Taken together, the results indicate the rather significant influence of the PTMs on the hydrophobic core dynamics, which propagates far beyond the local site of the chemical modification. The phosphorylated S8 fibrils display an overall rigidifying of the core based on the higher activation barriers of motions than the wild‐type fibrils, whereas the ΔE3 fibrils induce a broader variety of changes, some of which are thermodynamic in nature rather than the kinetic ones.
Comprehensive phenotyping of human peripheral blood B lymphocytes in pathological conditions
Authors: Carsetti Rita , Corrente Francesco , Capponi Claudia , Mirabella Mattia , Cascioli Simona , Palomba Patrizia , Bertaina Valentina , Pagliara Daria , Colucci Manuela , Piano Mortari Eva 
Published: December 2021

AbstractSeveral diseases are associated with alterations of the B‐cell compartment. Knowing how to correctly identify by flow cytometry the distribution of B‐cell populations in the peripheral blood is important to help in the early diagnosis. In the accompanying article we describe how to identify the different B‐cell subsets in the peripheral blood of healthy donors. Here we show a few examples of diseases that cause dysregulation of the B‐cell compartment.
A novel strategy for the detection of boldenone undecylenate misuse in cattle using ultra‐high performance liquid chromatography coupled to high resolution orbitrap mass spectrometry: From non‐targeted to targeted
Authors: Rocha Diego G. , Lana Mary Ane G. , de Assis Débora C. S. , de Macedo Adriana N. , Corrêa Joane M. M. , Augusti Rodinei , Faria Adriana F. 
Published: December 2021

AbstractIn this work multivariate strategies were employed in order to highlight new potential biomarkers of interest to detect the exogenous treatment of steers intramuscularly treated with boldenone undecylenate. Serum samples collected from treated (n = 4) and control (n = 8) crossbred animals of varying ages and weights were extracted using a simple sample preparation procedure based on salt assisted liquid–liquid extraction. Data acquisition was performed using liquid chromatography and Q‐Exactive™ Orbitrap mass spectrometry. Data processing and treatment were performed using two non‐targeted workflows: (1) Compound Discoverer software and (2) XCMS package on the open‐source R software combined with MetaboAnalyst. Three potential biomarkers were highlighted taking into account the chromatographic shapes, the feature location on the generated s‐plots, the fold change, the adjusted p values, the coefficient of variation in the QC samples and the area under the ROC curves. Predicted formulas based on mass accuracy, structural composition and spectra similarity were proposed. A robust statistical model to predict the boldenone treatment was further developed based on the weighted abundances of the selected biomarkers. The requirements for screening methods were successfully fulfilled, together with a wider detection window in comparison with the monitoring of the deconjugated metabolite boldenone, although biomarker identification studies are still ongoing.
NT‐proBNP as a marker for atrial fibrillation and heart failure in four observational outpatient trials
Authors: Werhahn Stefanie M. , Becker Christian , Mende Meinhard , Haarmann Helge , Nolte Kathleen , Laufs Ulrich , Zeynalova Samira , Löffler Markus , Dagres Nikolaos , Husser Daniela , Dörr Marcus , Gross Stefan , Felix Stephan B. , Petersmann Astrid , Herrmann‐Lingen Christoph , Binder Lutz , Scherer Martin , Hasenfuß Gerd , Pieske Burkert , Edelmann Frank , Wachter Rolf 
Published: December 2021

AbstractAimsHeart failure (HF) and atrial fibrillation (AF) frequently coexist and are both associated with increased levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP). It is known that AF impairs the diagnostic accuracy of NT‐proBNP for HF. The aim of the present study was to compare the diagnostic and predictive accuracy of NT‐proBNP for HF and AF in stable outpatients with cardiovascular risk factors.Methods and resultsData were obtained from the DIAST‐CHF trial, a prospective cohort study that recruited individuals with cardiovascular risk factors and followed them up for 12 years. Data were validated in three independent population‐based cohorts using the same inclusion/exclusion criteria: LIFE‐Adult (n = 2869), SHIP (n = 2013), and SHIP‐TREND (n = 2408). Serum levels of NT‐proBNP were taken once at baseline. The DIAST‐CHF study enrolled 1727 study participants (47.7% female, mean age 66.9 ± 8.1 years). At baseline, patients without AF or HF (n = 1375) had a median NT‐proBNP of 94 pg/mL (interquartile range 51;181). In patients with AF (n = 93), NT‐proBNP amounted to 667 (215;1130) pg/mL. It was significantly higher than in the first group (P < 0.001) and compared with those with only HF [n = 201; 158 (66;363) pg/mL; P < 0.001]. The highest levels of NT‐proBNP [868 (213;1397) pg/mL] were measured in patients with concomitant HF and AF (n = 58; P < 0.001 vs. control and vs. HF, P = 1.0 vs. AF). In patients with AF, NT‐proBNP levels did not differ between those with HF and preserved ejection fraction (EF) > 50% [n = 38; 603 (175;1070) pg/mL] and those without HF (P = 1.0). Receiver‐operating characteristic curves of NT‐proBNP showed a similar area under the curve (AUC) for the detection of AF at baseline (0.84, 95% CI [0.79–0.88]) and for HF with EF < 50% (0.78 [0.72–0.85]; P = 0.18). The AUC for HF with EF > 50% was significantly lower (0.61 [0.56–0.65]) than for AF (P = 0.001). During follow‐up, AF was newly diagnosed in 157 (9.1%) and HF in 141 (9.6%) study participants. NT‐proBNP was a better predictor of incident AF during the first 2 years (AUC: 0.79 [0.75–0.83]) than of newly diagnosed HF (0.59 [0.55–0.63]; P < 0.001). Data were validated in three independent population‐based cohorts (LIFE‐Adult, n = 2869; SHIP, n = 2013; and SHIP‐TREND, n = 2408).ConclusionsIn stable outpatients, NT‐proBNP is a better marker for prevalent and incident AF than for HF. In AF patients, the diagnostic value of NT‐proBNP for HF with EF > 50% is very limited.
Evolutionary de Winter pattern: from STEMI to de Winter ECG—a case report
Authors: Huang Weijun , Mai Linlin , Lu Jianhua , Li Wenshen , Huang Yuli , Hu Yunzhao 
Published: December 2021

AbstractThe de Winter electrocardiography (ECG) pattern is a sign that implies proximal left anterior descending coronary artery occlusion in patients with chest pain. We report a case of a 34‐year‐old man with a history of smoking who presented to the local emergency department with a 49 min history of chest pain. The first ECG of the patient indicated that ST‐segment elevation was noted in the lead V2–V4; 57 min later, a second ECG revealed a typical de Winter syndrome when the patient was transferred to the emergency chest pain centre of our hospital. A percutaneous coronary intervention (PCI) was performed approximately 8 h later because the patient initially refused the PCI. Acute coronary artery angiography showed that the proximal left anterior descending coronary artery was completely occluded. Our case suggests that ST‐segment elevation myocardial infarction may evolve in the direction of de Winter, which reflects a coronary thrombus in formation, so the de Winter ECG pattern should not be considered static.