bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐Altitude Ion Upflow Observed by EISCAT and its Effects on Supply of Molecular Ions in the Ring Current Detected by Arase (ERG)
Authors: Takada M. , Seki K. , Ogawa Y. , Keika K. , Kasahara S. , Yokota S. , Hori T. , Asamura K. , Miyoshi Y. , Shinohara I. 
Published: April 2021

AbstractDuring the magnetic storm starting on September 7, 2017, the MEP‐i instrument onboard the Arase (ERG) satellite observed molecular ions (O2+/NO+/N2+) in the ring current. The molecular ions were observed by Arase in four orbits during this magnetic storm. This indicates that there was a continuous molecular ion supply from the ionosphere. During the storm main phase around the second Dst minimum (∼−100 nT) on September 8, 2017, the European Incoherent Scatter (EISCAT) radar observed the ion upflow (∼50–150 m s−1) in the low‐altitude (250–350 km) ionosphere together with strong ion heating up to >2,000 K. The convective electric field derived from the electron heating observed by EISCAT at an altitude of approximately 110 km was also enhanced by a factor of 2. The observations suggest that the additional ion heating at low altitudes helps to cause the fast upflow and transport molecular ions upward. The flux decreases from 280 to 350 km altitudes due to the dissociative recombination was estimated to be approximately two orders of magnitude. This resulted in significant molecular ion flux remaining at 350 km altitude. These results suggest that the low‐altitude ion upflow caused by the ion frictional heating enables molecular ions to escape to space against rapid loss by the dissociative recombination.
Distribution of Temperature and Strength in the Central Andean Lithosphere and Its Relationship to Seismicity and Active Deformation
Authors: Ibarra F. , Prezzi C. B. , Bott J. , Scheck‐Wenderoth M. , Strecker M. R. 
Published: April 2021

AbstractWe present three‐dimensional (3D) models of the present‐day steady‐state conductive thermal field and strength distribution in the lithosphere beneath the Central Andes. Our primary objective was to investigate the influence that the structure of the Central Andean lithosphere has on its thermal and rheological state, and the relationship between the latter and the active deformation in the region. We used our previous data‐driven and gravity‐constrained 3D density model as starting point for the calculations. We first assigned lithology‐derived thermal and rheological properties to the different divisions of the density model and defined temperature boundary conditions. We then calculated the 3D steady‐state conductive thermal field and the maximum differential stresses for both brittle and ductile behaviors. We find that the thickness and composition of the crust are the main factors affecting the modeled thermal field, and consequently also the strength distribution. The orogen is characterized by a thick felsic crust with elevated temperatures and a low integrated strength, whereas the foreland and forearc are underlain by a more mafic and thinner crust with lower temperatures and a higher integrated strength. We find that most of the intraplate deformation coincides spatially with the steepest strength gradients and suggest that the high potential energy of the orogen together with the presence of rheological lateral heterogeneities produce high compressional stresses and strong strain localization along the margins of the orogen. We interpret earthquakes within the modeled ductile field to be related to the weakening effect of long‐lived faults and/or the presence of seismic asperities.
A Dual‐Polarized Frequency Selective Rasorber With Wide Transmission Band
Authors: Jiao W. H. , Chang Y. M. , Wang L. , Wu W. J. 
Published: April 2021

AbstractIn this paper, a novel and simple dual‐polarized frequency‐selective rasorber (FSR) which has a wide absorption band including a wide transmission band was presented. Detailed equivalent circuit was derived to accurately predict the frequency responses of the structure. Based on reasonable equivalent analysis of a traditional metal grid structure, a modified structure with improved performance was proposed. The structure consists of a lossy frequency‐selective surface (FSS) constructed with metal rings connected by center loaded strips as the top layer, and a broadband transmission FSS at the bottom, while the two layers are separated by air. To validate our proposal, a prototype was fabricated and measured. The measured results are in good agreements with simulations under normal incidence, which indicates a broad absorption bandwidth of 80% that from 3.40 to 8.16 GHz; in the meantime, a wide transmission band with an insertion loss of less than −1.25 dB is ranging from 9.03 to 12.01 GHz. It should be pointed out that, the reflection from the whole structure in the operation band can be kept below −10 dB from 4.15 to 11.87 GHz.
The p53-caspase-2 axis in the cell cycle and DNA damage response
Authors: Lim Yoon , Dorstyn Loretta , Kumar Sharad 
Published: April 2021

AbstractCaspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (DRONC and caspase-9, respectively), the function of caspase-2 in apoptosis has remained enigmatic. A number of recent studies suggest that caspase-2 plays an important role in the regulation of p53 in response to cellular stress and DNA damage to prevent the proliferation and accumulation of damaged or aberrant cells. Here, we review these recent observations and their implications in caspase-2-mediated cellular death, senescence, and tumor suppression.
Blood pressure and resting heart rate in 3-17-year-olds in Germany in 2003–2006 and 2014–2017
Authors: Sarganas Giselle , Schienkiewitz Anja , Finger Jonas D. , Neuhauser Hannelore K. 
Published: April 2021

AbstractTo track blood pressure (BP) and resting heart rate (RHR) in children and adolescents is important due to its associations with cardiovascular outcomes in the adulthood. Therefore, the aim of this study was to examine BP and RHR over a decade among children and adolescents living in Germany using national examination data. Cross-sectional data from 3- to 17-year-old national survey participants (KiGGS 2003–06,n = 14,701; KiGGS 2014–17,n = 3509) including standardized oscillometric BP and RHR were used for age- and sex-standardized analysis. Measurement protocols were identical with the exception of the cuff selection rule, which was accounted for in the analyses. Different BP and RHR trends were observed according to age-groups. In 3- to 6-year-olds adjusted mean SBP and DBP were significantly higher in 2014–2017 compared to 2003–2006 (+2.4 and +1.9 mm Hg, respectively), while RHR was statistically significantly lower by −3.8 bpm. No significant changes in BP or in RHR were observed in 7- to 10-year-olds over time. In 11- to 13-year-olds as well as in 14- to 17-year-olds lower BP has been observed (SBP −2.4 and −3.2 mm Hg, respectively, and DBP −1.8 and −1.7 mm Hg), while RHR was significantly higher (+2.7 and +3.7 bpm). BP trends did not parallel RHR trends. The downward BP trend in adolescents seemed to follow decreasing adult BP trends in middle and high-income countries. The increase in BP in younger children needs confirmation from other studies as well as further investigation. In school-aged children and adolescents, the increased RHR trend may indicate decreased physical fitness.
A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis
Authors: Wang Xiangyu , Li Zhaozheng , Bai Yang , Zhang Rui , Meng Ran , Chen Fangping , Wang Haichao , Billiar Timothy R. , Xiao Xianzhong , Lu Ben , Tang Yiting 
Published: April 2021

AbstractCaspase-11, a cytosolic lipopolysaccharide (LPS) receptor, mediates lethal immune responses and coagulopathy in sepsis, a leading cause of death worldwide with limited therapeutic options. We previously showed that over-activation of caspase-11 is driven by hepatocyte-released high mobility group box 1 (HMGB1), which delivers extracellular LPS into the cytosol of host cells during sepsis. Using a phenotypic screening strategy with recombinant HMGB1 and peritoneal macrophages, we discovered that FeTPPS, a small molecule selectively inhibits HMGB1-mediated caspase-11 activation. The physical interaction between FeTPPS and HMGB1 disrupts the HMGB1-LPS binding and decreases the capacity of HMGB1 to induce lysosomal rupture, leading to the diminished cytosolic delivery of LPS. Treatment of FeTPPS significantly attenuates HMGB1- and caspase-11-mediated immune responses, organ damage, and lethality in endotoxemia and bacterial sepsis. These findings shed light on the development of HMGB1-targeting therapeutics for lethal immune disorders and might open a new avenue to treat sepsis.
Moving somatic gene editing to the clinic: routes to market access and reimbursement in Europe
Authors: Rigter Tessel , Klein David , Weinreich Stephanie S. , Cornel Martina C. 
Published: April 2021

AbstractSomatic gene editing (SGE) holds great promise for making genetic therapy possible for many monogenic conditions very soon. Is our current system of European market authorization and reimbursement ready for the expected tsunami of gene therapies? At a recent workshop of the Netherlands ZonMw consortium on ethical, legal, and social implications of personalized medicine, we discussed the current possibilities for bringing new gene therapies to the clinic. In Europe, it is not yet clear whether the route via the European medicines agency as an advanced therapy medicinal product is the most appropriate for evaluation of highly personalized SGE applications, although this may optimally guarantee safety and effectiveness. Compassionate use may ensure faster access than the centralized procedure but does not stimulate the commercial development of products. Prescription to named patients may only provide adequate access for single patients. Temporary authorization of use may allow access to medication half a year before formal market authorization has been granted, but may also have large budget impacts. Magistral compounding under a hospital exemption may be an attractive solution for rare, tailor-made applications at an acceptable price. To approve local experimental use of a therapy on a case-by-case basis may be fast, but does not guarantee optimal safety, effectiveness, and broad implementation. We argue that alternative routes should be considered for products developed for a market of large groups of patients versus unique personalized treatments. A balance between scientific evidence for safety and effectiveness, affordability, and fast access may demand a range of alternative solutions.
Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
Authors: Huang Hao , Hu Jianyang , Maryam Alishba , Huang Qinghua , Zhang Yuchen , Ramakrishnan Saravanan , Li Jingyu , Ma Haiying , Ma Victor W. S. , Cheuk Wah , So Grace Y. K. , Wang Wei , Cho William C. S. , Zhang Liang , Chan Kui Ming , Wang Xin , Chin Y. Rebecca 
Published: April 2021

AbstractBreast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet the functional role of cis-regulatory elements including super-enhancers in different breast cancer subtypes remains poorly characterized. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis. Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between breast cancer subtypes, and provide clinically relevant biological insights towards TNBC. Using CRISPR/Cas9-mediated gene editing, we identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1 and MET, thereby unveiling a mechanism for specific overexpression of the key oncogenes in TNBC. We also identify ANLN as a TNBC-specific gene regulated by super-enhancer. Our studies reveal a TNBC-specific epigenomic landscape, contributing to the dysregulated oncogene expression in breast tumorigenesis.
Comprehensive omic characterization of breast cancer in Mexican-Hispanic women
Authors: Romero-Cordoba Sandra L. , Salido-Guadarrama Ivan , Rebollar-Vega Rosa , Bautista-Piña Veronica , Dominguez-Reyes Carlos , Tenorio-Torres Alberto , Villegas-Carlos Felipe , Fernández-López Juan C. , Uribe-Figueroa Laura , Alfaro-Ruiz Luis , Hidalgo-Miranda Alfredo 
Published: April 2021

AbstractBreast cancer is a heterogeneous pathology, but the genomic basis of its variability remains poorly understood in populations other than Caucasians. Here, through DNA and RNA portraits we explored the molecular features of breast cancers in a set of Hispanic-Mexican (HM) women and compared them to public multi-ancestry datasets. HM patients present an earlier onset of the disease, particularly in aggressive clinical subtypes, compared to non-Hispanic women. The age-related COSMIC signature 1 was more frequent in HM women than in those from other ancestries. We found the AKT1E17K hotspot mutation in 8% of the HM women and identify the AKT1/PIK3CA axis as a potentially druggable target. Also, HM luminal breast tumors present an enhanced immunogenic phenotype compared to Asiatic and Caucasian tumors. This study is an initial effort to include patients from Hispanic populations in the research of breast cancer etiology and biology to further understand breast cancer disparities.
Squeezed light from a nanophotonic molecule
Authors: Zhang Y. , Menotti M. , Tan K. , Vaidya V. D. , Mahler D. H. , Helt L. G. , Zatti L. , Liscidini M. , Morrison B. , Vernon Z. 
Published: April 2021

AbstractDelicate engineering of integrated nonlinear structures is required for developing scalable sources of non-classical light to be deployed in quantum information processing systems. In this work, we demonstrate a photonic molecule composed of two coupled microring resonators on an integrated nanophotonic chip, designed to generate strongly squeezed light uncontaminated by noise from unwanted parasitic nonlinear processes. By tuning the photonic molecule to selectively couple and thus hybridize only the modes involved in the unwanted processes, suppression of parasitic parametric fluorescence is accomplished. This strategy enables the use of microring resonators for the efficient generation of degenerate squeezed light: without it, simple single-resonator structures cannot avoid contamination from nonlinear noise without significantly compromising pump power efficiency. We use this device to generate 8(1) dB of broadband degenerate squeezed light on-chip, with 1.65(1) dB directly measured.
A systematic approach to generating accurate neural network potentials: the case of carbon
Authors: Shaidu Yusuf , Küçükbenli Emine , Lot Ruggero , Pellegrini Franco , Kaxiras Efthimios , de Gironcoli Stefano 
Published: April 2021

AbstractAvailability of affordable and widely applicable interatomic potentials is the key needed to unlock the riches of modern materials modeling. Artificial neural network-based approaches for generating potentials are promising; however, neural network training requires large amounts of data, sampled adequately from an often unknown potential energy surface. Here we propose a self-consistent approach that is based on crystal structure prediction formalism and is guided by unsupervised data analysis, to construct an accurate, inexpensive, and transferable artificial neural network potential. Using this approach, we construct an interatomic potential for carbon and demonstrate its ability to reproduce first principles results on elastic and vibrational properties for diamond, graphite, and graphene, as well as energy ordering and structural properties of a wide range of crystalline and amorphous phases.
Prediction of high thermoelectric performance in the low-dimensional metal halide Cs3Cu2I5
Authors: Jung Young-Kwang , Han In Taek , Kim Yong Churl , Walsh Aron 
Published: April 2021

AbstractMetal halides have emerged as a new generation of semiconductors with applications ranging from solar cells to chemical sensors. We assess the thermoelectric potential of Cs3Cu2I5, which has a crystal structure formed of zero-dimensional [Cu2I5]3− anionic clusters that are separated by Cs+ counter cations. We find the compound exhibits the characteristics of a phonon-glass electron-crystal with a large imbalance in the conduction of heat and electrons predicted from first-principles transport theory. Strong anharmonic phonon–phonon scattering results in short-lived acoustic vibrations and an ultra-low lattice thermal conductivity (<0.1 W m−1 K−1). The dispersive conduction band leads to a high electron mobility (>10 cm2 V−1 s−1). For an n-type crystal at 600 K, a thermoelectric figure-of-merit ZT of 2.6 is found to be accessible, which for a cold source of 300 K corresponds to a thermodynamic heat-to-electricity conversion efficiency of 15%.
Delayed orthostatic hypotension in Parkinson’s disease
Authors: Yoo Sang-Won , Kim Joong-Seok , Yoo Ji-Yeon , Yun Eunkyeong , Yoon Uicheul , Shin Na-Young , Lee Kwang-Soo 
Published: April 2021

AbstractOrthostatic hypotension (OH) is relatively common in the early stage of Parkinson’s disease (PD). It is divided into delayed OH and classical OH. Classical OH in PD has been investigated widely, however, the clinical implications of delayed OH in PD have seldom been studied. The purpose of this study is to characterize delayed OH in PD. A total of 285 patients with early drug-naïve PD were enrolled and divided into three groups according to orthostatic change: no-OH, delayed OH, and classical OH. The disease severity in terms of motor, non-motor, and cognitive functions was assessed. The cortical thickness of 82 patients was analyzed with brain magnetic resonance imaging. The differences among groups and linear tendency in the order of no-OH, delayed OH, and classical OH were investigated. Seventy-seven patients were re-evaluated. Initial and follow-up evaluations were explored to discern any temporal effects of orthostasis on disease severity. Sixty-four (22.5%) patients were defined as having delayed OH and 117 (41.1%) had classical OH. Between-group comparisons revealed that classical OH had the worst outcomes in motor, non-motor, cognitive, and cortical thickness, compared to the other groups. No-OH and delayed OH did not differ significantly. Linear trends across the pre-ordered OH subtypes found that clinical parameters worsened along with the orthostatic challenge. Clinical scales deteriorated and the linear gradient was maintained during the follow-up period. This study suggests that delayed OH is a mild form of classical OH in PD. PD with delayed OH has milder disease severity and progression.
Detection of exogenous sugars in pineapple juice using compound-specific stable hydrogen isotope analysis
Authors: Kelly Simon D. , Abrahim Aiman , Rinke Peter , Cannavan Andrew 
Published: April 2021

AbstractAn improved procedure for determining 2H/1H isotope ratios, using gas chromatography-isotope ratio mass spectrometry, has been used to detect the addition of exogenous C4-plant-derived sugars to pineapple juice. Isotopic techniques are commonly used to identify the addition of low-cost sugars to fruit juices and are difficult to subvert as it is not economically viable to change the isotopic ratios of the sugars. However, the addition of cane sugar to pineapple juice has presented a significant challenge that is only detected by site-specific 13C analysis of the methyl and methylene positions of ethanol derived from pineapple sugars, measured by nuclear magnetic resonance. This new GC-IRMS-based procedure utilises the trifluoroacetate derivative of sucrose to allow direct measurement of the carbon-bound non-exchangeable hydrogen. This provides advantages over alternative isotopic methods in terms of analysis time and sensitivity. This feasibility study has demonstrated the potential to reliably differentiate between authentic pineapple juices and those adulterated with commercial beet and cane sucrose.
BonZeb: open-source, modular software tools for high-resolution zebrafish tracking and analysis
Authors: Guilbeault Nicholas C. , Guerguiev Jordan , Martin Michael , Tate Isabelle , Thiele Tod R. 
Published: April 2021

AbstractWe present BonZeb—a suite of modular Bonsai packages which allow high-resolution zebrafish tracking with dynamic visual feedback. Bonsai is an increasingly popular software platform that is accelerating the standardization of experimental protocols within the neurosciences due to its speed, flexibility, and minimal programming overhead. BonZeb can be implemented into novel and existing Bonsai workflows for online behavioral tracking and offline tracking with batch processing. We demonstrate that BonZeb can run a variety of experimental configurations used for gaining insights into the neural mechanisms of zebrafish behavior. BonZeb supports head-fixed closed-loop and free-swimming virtual open-loop assays as well as multi-animal tracking, optogenetic stimulation, and calcium imaging during behavior. The combined performance, ease of use and versatility of BonZeb opens new experimental avenues for researchers seeking high-resolution behavioral tracking of larval zebrafish.
Non-invasive characterization of complex coronary lesions
Authors: Vardhan Madhurima , Gounley John , Chen S. James , Chi Eric C. , Kahn Andrew M. , Leopold Jane A. , Randles Amanda 
Published: April 2021

AbstractConventional invasive diagnostic imaging techniques do not adequately resolve complex Type B and C coronary lesions, which present unique challenges, require personalized treatment and result in worsened patient outcomes. These lesions are often excluded from large-scale non-invasive clinical trials and there does not exist a validated approach to characterize hemodynamic quantities and guide percutaneous intervention for such lesions. This work identifies key biomarkers that differentiate complex Type B and C lesions from simple Type A lesions by introducing and validating a coronary angiography-based computational fluid dynamic (CFD-CA) framework for intracoronary assessment in complex lesions at ultrahigh resolution. Among 14 patients selected in this study, 7 patients with Type B and C lesions were included in the complex lesion group including ostial, bifurcation, serial lesions and lesion where flow was supplied by collateral bed. Simple lesion group included 7 patients with lesions that were discrete, $$<10\hbox {mm}$$

<
10
mm

long and readily accessible. Intracoronary assessment was performed using CFD-CA framework and validated by comparing to clinically measured pressure-based index, such as FFR. Local pressure, endothelial shear stress (ESS) and velocity profiles were derived for all patients. We validates the accuracy of our CFD-CA framework and report excellent agreement with invasive measurements ($$n=14, R^2 = 0.6, p = 0.0013$$

n
=
14
,

R
2

=
0.6
,
p
=
0.0013

). Ultra-high resolution achieved by the model enable physiological assessment in complex lesions and quantify hemodynamic metrics in all vessels up to 1mm in diameter. Importantly, we demonstrate that in contrast to traditional pressure-based metrics, there is a significant difference in the intracoronary hemodynamic forces, such as ESS, in complex lesions compared to simple lesions at both resting and hyperemic physiological states [n = 14, $$p=0.03$$

p
=
0.03

]. Higher ESS was observed in the complex lesion group ($$7.0\pm 4.7$$

7.0
±
4.7

Pa) than in simple lesion group ($$4.8\pm 3.6$$

4.8
±
3.6

Pa). Complex coronary lesions have higher ESS compared to simple lesions, such differential hemodynamic evaluation can provide much the needed insight into the increase in adverse outcomes for such patients and has incremental prognostic value over traditional pressure-based indices, such as FFR.