bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
Authors: Tanaka Sébastien , De Tymowski Christian , Zappella Nathalie , Snauwaert Aurélie , Robert Tiphaine , Lortat-Jacob Brice , Castier Yves , Tran-Dinh Alexy , Tashk Parvine , Bouzid Donia , Para Marylou , Pellenc Quentin , Atchade Enora , Meilhac Olivier , Montravers Philippe 
Published: August 2021

AbstractExtracorporeal membrane oxygenation (ECMO), a relevant technology for patients with acute respiratory distress syndrome (ARDS) or acute cardiac failure (ACF), is a frequent cause of systemic inflammatory response syndrome. During sepsis, HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) concentrations decrease, and an association between low lipoprotein levels and poor outcomes was reported. There are no data from patients undergoing ECMO. The goal of this study was to characterize the lipoprotein profiles of ICU patients requiring ECMO. All consecutive patients admitted for ARDS or ACF requiring ECMO were prospectively included. Daily lipoprotein levels and short-term prognosis outcome were assessed. 25 patients were included. On admission, lipoprotein concentrations were low, under the reference values ([HDL-C] = 0.6[0.4–0.8]mmol/L;[LDL-C] = 1.3[1.0–1.7]mmol/L). A statistically significant rise in lipoproteins overtime was observed during the ICU stay. We found no relationship between lipoproteins concentrations and mortality on Day-28 (p = 0.689 and p = 0.979, respectively). Comparison of surviving patients with non-surviving patients did not reveal any differences in lipoproteins concentrations. Stratification between septic and non-septic patients demonstrated that septic patients had lower lipoproteins concentrations on admission (HDL-C: 0.5[0.3–0.6]mmol/l vs 0.8[0.6–0.9]mmol/l, p = 0.003; LDL-C: 1.1[0.9–1.5]mmol/l vs 1.5[1.3–2.6]mmol/l; p = 0.012), whereas these two groups were comparable in terms of severity and outcomes. HDL-C concentrations during ICU hospitalization were also significantly lower in the septic group than in the non-septic group (p = 0.035). In conclusion, Lipoprotein concentrations are low in patients requiring ECMO but are not associated with poor outcomes. The subpopulation of septic patients had lower lipoprotein levels overtime, which reinforces the potential key-role of these particles during sepsis.
High-intensity infrasound effects on glucose metabolism in rats
Authors: Pereira Gonçalo Martins , Santos Madalena , Pereira Sofia S. , Borrecho Gonçalo , Tortosa Francisco , Brito José , Freitas Diamantino , de Carvalho António Oliveira , Águas Artur , Oliveira Maria João , Oliveira Pedro 
Published: August 2021

AbstractRecent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar rats were randomly divided in two groups: one group not exposed to HII and the other continuously exposed to HII. Animals were sacrificed at three timepoints of exposure (1, 6 or 12 weeks). An intraperitoneal glucose tolerance test was performed, blood samples were collected and the pancreas and the quadriceps femoris muscle were excised. Circulating insulin and corticosterone levels were determined and pancreatic and muscular tissue were routinely processed for histochemistry and immunohistochemistry with an anti-GLUT4 antibody. Animals exposed to HII had higher corticosterone levels than animals not exposed. No differences were found on insulin concerning HII exposure or glucose intolerance. Glucose intolerant animals had pancreatic islet fibrosis and no differences were found in GLUT4 ratio concerning HII exposure. In conclusion, we found that continuous exposure to HII increases stress hormone levels without inducing glucose intolerance in rats.
Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
Authors: Adhikari Aniruddha , Mondal Susmita , Chatterjee Tanima , Das Monojit , Biswas Pritam , Ghosh Ria , Darbar Soumendra , Alessa Hussain , Althakafy Jalal T. , Sayqal Ali , Ahmed Saleh A. , Das Anjan Kumar , Bhattacharyya Maitree , Pal Samir Kumar 
Published: August 2021

AbstractTargeting reactive oxygen species (ROS) while maintaining cellular redox signaling is crucial in the development of redox medicine as the origin of several prevailing diseases including chronic kidney disease (CKD) is linked to ROS imbalance and associated mitochondrial dysfunction. Here, we have shown that a potential nanomedicine comprising of Mn3O4 nanoparticles duly functionalized with biocompatible ligand citrate (C-Mn3O4 NPs) can maintain cellular redox balance in an animal model of oxidative injury. We developed a cisplatin-induced CKD model in C57BL/6j mice with severe mitochondrial dysfunction and oxidative distress leading to the pathogenesis. Four weeks of treatment with C-Mn3O4 NPs restored renal function, preserved normal kidney architecture, ameliorated overexpression of pro-inflammatory cytokines, and arrested glomerulosclerosis and interstitial fibrosis. A detailed study involving human embryonic kidney (HEK 293) cells and isolated mitochondria from experimental animals revealed that the molecular mechanism behind the pharmacological action of the nanomedicine involves protection of structural and functional integrity of mitochondria from oxidative damage, subsequent reduction in intracellular ROS, and maintenance of cellular redox homeostasis. To the best of our knowledge, such studies that efficiently treated a multifaceted disease like CKD using a biocompatible redox nanomedicine are sparse in the literature. Successful clinical translation of this nanomedicine may open a new avenue in redox-mediated therapeutics of several other diseases (e.g., diabetic nephropathy, neurodegeneration, and cardiovascular disease) where oxidative distress plays a central role in pathogenesis.
High-efficiency nitrate electroreduction to ammonia on electrodeposited cobalt–phosphorus alloy film
Authors: Li Zerong , Wen Guilai , Liang Jie , Li Tingshuai , Luo Yonglan , Kong Qingquan , Shi Xifeng , Asiri Abdullah M. , Liu Qian , Sun Xuping 
Published: August 2021

Ti plate supported cobalt-phosphorus alloy film acts as an active and selective electrocatalyst for ambient NO3−-to-NH3 conversion. In 0.2 M Na2SO4 with 200 ppm NO3−, it offers a NH3 yield rate of 416.0 ± 7.2 μg h−1 cm−2 with a Faradaic efficiency of 93.6 ± 3.3% at −0.6 and −0.3 V vs. RHE, respectively.
The Effects of Written Stuttering Disclosure on the Perceptions of a Child Who Stutters
Authors: Snyder Greg , Manahan Ashlee , McKnight Peyton , Kornisch Myriam 
Published: August 2021

Purpose
This study measured between-groups differences in perceived speech skills and personality characteristics of a 12-year-old male child who stutters (CWS) as a function of a written factual stuttering disclosure statement, delivered by the CWS, his “mother,” or his “teacher.”

Method
Four hundred twenty-four college-age adults were assigned to one of four groups, including three experimental groups (i.e., written self-disclosure, mother-written disclosure, and teacher-written disclosure) and a control group (no written disclosure). Participants in the control conditions viewed a brief video of the CWS. In the experimental conditions, participants read a brief written disclosure statement for 30 s, followed by the same video used in the control condition. After viewing the video, all participants completed surveys relative to their perceptions of the CWS speech skills and personality characteristics.

Results
Results reveal that a written stuttering disclosure statement provided by the mother correlated with select significant desirable perceptual differences of the CWS, while a written disclosure statement provided by the CWS yielded insignificant or even undesirable perceptual differences of the CWS. Written stuttering disclosures provided by a “teacher” did not yield any significant between-groups differences in the perception of a CWS. Gender affiliation was found to be a source of covariance in a number of perceived speech skills and personality characteristics.

Conclusions
Written stuttering disclosure statements provided by the “mother” correlated with select favorable perceptual differences of speech skills and personal characteristics of a CWS. Clinically, the application of novel methods (written and oral disclosure statements) and sources (i.e., CWS advocates such as “mother” and “teacher”) of stuttering disclosure statement can be integrated into a systematic therapeutic program, creating an innovative approach of scaffolding self-advocacy via stuttering disclosure in CWS.

Supplemental Material

https://doi.org/10.23641/asha.15505857
An improved YOLOv3‐tiny algorithm for vehicle detection in natural scenes
Authors: Huang Bingqiang , Lin Haiping , Hu Zejun , Xiang Xinjian , Yao Jiana 
Published: August 2021

AbstractYOLO (You Only Look Once), as a target detection algorithm with good speed and precision, is widely used in the industry. In the process of driving, the vehicle image captured by the driving camera is detected and it extracts the license plate and the front part of the vehicle. Compared with the network structure of YOLOv3‐tiny algorithm, the acquisition method of anchor box is improved by combining the Birch algorithm. In order to improve the real‐time performance, the original two‐scale detection is added to the multi‐scale prediction of three‐scale detection to ensure its accuracy. Finally, the experimental results show that the improved YOLOv3‐tiny network structure proposed in this study can improve the performance of mean‐average‐precision, intersection over union and speed by 5.99%, 17.52% and 48.4%, respectively, and the algorithm has certain robustness.
Formation and influence analysis of electrolytic corrosion products on insulator surface
Authors: Cao Bin , Li Zong , Yang Daiming , Mu Lei , Liu Peng , Wang Liming , Yang Lianwu , Wu Yankun 
Published: August 2021

AbstractNowadays, end fitting corrosion reduces the mechanical strength and flashover voltage of insulators, forming a huge threat to high‐voltage direct current transmission lines. At present, the parameters of electrolytic corrosion inhibition measures are selected based on the premise of the constant annual corrosion rate. However, with the development of corrosion, corrosion products accumulate on the insulator surface, which may impact the corrosion rate. In order to clarify the influence of corrosion products, this work studied how corrosion products influence the corrosion rate from the corrosion phenomenon, corrosion current, feature and formation of corrosion products. The results showed that corrosion products of iron and zinc were excellent in adhesion on the insulator surface and could not be cleaned by rain, which was able to increase the corrosion rate. In future, in the selection of the quality of the zinc ring bonded on insulator fittings, there will be a demand to consider the influence of corrosion products on the corrosion rate.
Non‐invasive assessment of knee osteoarthritis patients using thermal imaging
Authors: Lohchab Viney , Rathod Pratik , Mahapatra Prasant K. , Bachhal Vikas , Hooda Aman 
Published: August 2021

AbstractRadiography is a widely used method for grading and tracking the anatomical changes in knee osteoarthritis (OA) patients. The ease of thermography in mapping functional information via the skin temperature (Tsk) helps in the diagnosis of various musculoskeletal diseases. There is a significant involvement of soft tissues in knee OA due to the complex osteoligamentous degeneration, which may affect the knee Tsk. A total of 62 patients with knee OA were analysed using thermography. The mean Tsk was computed by extracting the region of interest from the acquired thermal images using an automatic segmentation technique for frontal, lateral, and medial views. The mean Tsk for grade 1, 2, 3 and 4 were 30.96 ± 0.59, 31.56 ± 0.79, 31.40 ± 1.22, 32.20 ± 0.70 ˚C respectively. A significant temperature difference was found between grade 2 and 4 (p = 0.02, p = 0.018), grade 3 and 4 (p = 0.03, p = 0.02) for frontal and lateral views; whereas no significant difference was found between grade 2 and 3. Further, 2‐way ANOVA test showed that risk factors (like age, BMI and duration of disease) do affect the mean Tsk significantly with a p‐value of 0.0003, 0.02, and 0.008.
ENHANCED GRAVITROPISM 2encodes a STERILE ALPHA MOTIF–containing protein that controls root growth angle in barley and wheat
Authors: Kirschner Gwendolyn K. , Rosignoli Serena , Guo Li , Vardanega Isaia , Imani Jafargholi , Altmüller Janine , Milner Sara G. , Balzano Raffaella , Nagel Kerstin A. , Pflugfelder Daniel , Forestan Cristian , Bovina Riccardo , Koller Robert , Stöcker Tyll G. , Mascher Martin , Simmonds James , Uauy Cristobal , Schoof Heiko , Tuberosa Roberto , Salvi Silvio , Hochholdinger Frank 
Published: August 2021

SignificanceTo date, the potential of utilizing root traits in plant breeding remains largely untapped. In this study, we cloned and characterized theENHANCED GRAVITROPISM2(EGT2) gene of barley that encodes a STERILE ALPHA MOTIF domain–containing protein. We demonstrated thatEGT2is a key gene of root growth angle regulation in response to gravity, which is conserved in barley and wheat and could be a promising target for crop improvement in cereals.
ChlamydomonasLZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip
Authors: Sun Wei-Yue , Xue Bin , Liu Yan-Xia , Zhang Rui-Kai , Li Rong-Chao , Xin Wen , Wu Mingfu , Fan Zhen-Chuan 
Published: August 2021

SignificanceBardet–Biedl syndrome (BBS) characteristic of blindness, obesity, and kidney anomalies is a rare human ciliopathy. BBS could result from disrupted ciliary dynamics of the BBSome, a conserved octamer of BBS proteins, which facilitates intraflagellar transport with the ciliary entry and/or removal of signaling proteins. Here, we show that LZTFL1 mediates phototaxis through balancing BBSomes available for transporting into and out of cilia. LZTFL1 controls the BBSome basal body amount available for entering cilia by promoting BBS3 targeting to the basal bodies. LZTFL1 simultaneously promotes BBSome removal out of cilia by stabilizing IFT25/27, a regulator essential for BBSome reassembly at the ciliary tip. LZTFL1 applies this dual-mode system to maintain BBSome ciliary dynamics, providing a mechanistic mechanism for BBS disorder.
SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice
Authors: Miyata Haruhiko , Oura Seiya , Morohoshi Akane , Shimada Keisuke , Mashiko Daisuke , Oyama Yuki , Kaneda Yuki , Matsumura Takafumi , Abbasi Ferheen , Ikawa Masahito 
Published: August 2021

Significance
Calcineurin is a target of immunosuppressive drugs such as cyclosporine A and tacrolimus. In the immune system, calcineurin interacts with NFAT via the PxIxIT motif to activate T cells. In contrast, little is known about the proteins that interact with a testis-enriched calcineurin that is essential for sperm motility and male fertility. Here, we discovered that calcineurin interacts with SPATA33 via a PQIIIT sequence in the testis. Further analyses reveal that SPATA33 plays critical roles in sperm motility and male fertility. Our finding sheds new light on the molecular mechanisms of sperm motility regulation and the etiology of human male fertility. Furthermore, it may help us not only understand reproductive toxicities but also develop nonhormonal male contraceptives.
Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein
Authors: Toyama Yuki , Harkness Robert W. , Kay Lewis E. 
Published: August 2021

Significance
The HtrA2 enzyme removes toxic proteins in mitochondria, ensuring proper cellular function. HtrA2 malfunction is associated with neurodegenerative disorders such as Parkinson’s disease and essential tremor. HtrA2 is composed of three copies of a protein chain, and the ways in which these chains communicate to form a functional enzyme are not well understood. Here, we have used NMR spectroscopy in concert with a strategy for producing trimers containing different types of chains to elucidate the mechanisms by which the HtrA2 enzyme is regulated. Our data lead to a model explaining how HtrA2 suppresses proteolysis of nonsubstrate proteins and, furthermore, how a single point mutation in HtrA2 that leads to neurodegeneration in mice gives rise to an inactive enzyme.
Laser-subcycle control of electronic excitation across system boundaries
Authors: Dorner-Kirchner Martin , Erattupuzha Sonia , Larimian Seyedreza , Koch Markus , Hanus Václav , Kangaparambil Sarayoo , Paulus Gerhard , Baltuška Andrius , Xie Xinhua , Kitzler-Zeiler Markus , Wang YanLan , Lai XuanYang , Yu ShaoGang , Sun RenPing , Liu XiaoJun 
Published: August 2021

Abstract
We report on the results of a joint experimental and numerical study on the sub-cycle laser field-driven electron dynamics that underlie the population of highly excited electronic states in multiply ionized argon dimers by electron recapture processes. Our experiments using few-cycle laser pulses with a known carrier-envelope phase (CEP) in combination with reaction microscopy reveal a distinct CEP-dependence of the electron emission and recapture process and, furthermore, a small but significant CEP-offset to the scenario in which no excited argon dimers are produced. With the help of classical ensemble trajectory simulations we trace down these different CEP-dependencies to subtle differences in the laser-driven sub-cycle electron trajectory dynamics that involve in both cases the transfer of an electron from one argon ion across the system boundary to the neighboring ion and its transient capture on this ion.
Near-infrared emission from spatially indirect excitons in type II ZnTe/CdSe/(Zn,Mg)Te core/double-shell nanowires
Authors: Wojnar Piotr , Płachta Jakub , Reszka Anna , Lähnemann Jonas , Kaleta Anna , Kret Sławomir , Baranowski Piotr , Wójcik Maciej , Kowalski Bogdan J , Baczewski Lech T , Karczewski Grzegorz , Wojtowicz Tomasz 
Published: August 2021

Abstract
ZnTe/CdSe/(Zn, Mg)Te core/double-shell nanowires are grown by molecular beam epitaxy by employing the vapor–liquid–solid growth mechanism assisted with gold catalysts. A photoluminescence study of these structures reveals the presence of an optical emission in the near infrared. We assign this emission to the spatially indirect exciton recombination at the ZnTe/CdSe type II interface. This conclusion is confirmed by the observation of a significant blue-shift of the emission energy with an increasing excitation fluence induced by the electron–hole separation at the interface. Cathodoluminescence measurements reveal that the optical emission in the near infrared originates from nanowires and not from two-dimensional residual deposits between them. Moreover, it is demonstrated that the emission energy in the near infrared depends on the average CdSe shell thickness and the average Mg concentration within the (Zn, Mg)Te shell. The main mechanism responsible for these changes is associated with the strain induced by the (Zn, Mg)Te shell in the entire core/shell nanowire heterostructure.
Investigating the accuracy of co-registered ionoacoustic and ultrasound images in pulsed proton beams
Authors: Lascaud Julie , Dash Pratik , Wieser Hans-Peter , Kalunga Ronaldo , Würl Matthias , Assmann Walter , Parodi Katia 
Published: August 2021

Abstract
The sharp spatial and temporal dose gradients of pulsed ion beams result in an acoustic emission (ionoacoustics), which can be used to reconstruct the dose distribution from measurements at different positions. The accuracy of range verification from ionoacoustic images measured with an ultrasound linear array configuration is investigated both theoretically and experimentally for monoenergetic proton beams at energies relevant for pre-clinical studies (20 and 22 MeV). The influence of the linear sensor array arrangement (length up to 4 cm and number of elements from 5 to 200) and medium properties on the range estimation accuracy are assessed using time-reversal reconstruction. We show that for an ideal homogeneous case, the ionoacoustic images enable a range verification with a relative error lower than 0.1%, however, with limited lateral dose accuracy. Similar results were obtained experimentally by irradiating a water phantom and taking into account the spatial impulse response (geometry) of the acoustic detector during the reconstruction of pressures obtained by moving laterally a single-element transducer to mimic a linear array configuration. Finally, co-registered ionoacoustic and ultrasound images were investigated using silicone inserts immersed in the water phantom across the proton beam axis. By accounting for the sensor response and speed of sound variations (deduced from co-registration with ultrasound images) the accuracy is improved to a few tens of micrometers (relative error less than to 0.5%), confirming the promise of ongoing developments for ionoacoustic range verification in pre-clinical and clinical proton therapy applications.
Copper oxide phases probed via plasmonic light emission in the STM
Authors: Gloystein Alexander , Nilius Niklas 
Published: August 2021

Abstract
Luminescence spectroscopy with a scanning tunnelling microscope (STM) is employed to differentiate bulk-type Cu2O from a Cu3O2 surface oxide at the nanometre scale. Although plasmonic modes in the tunnelling gap are responsible for the emission response in both cases, the luminescence cross-section shows a characteristic dependence on bias voltage for the two oxide phases. On the Cu3O2 surface oxide, the emission yield peaks at the 1st field emission resonance of the STM junction, when particularly high inelastic tunnelling rates are realized between tip and sample. On Cu2O(111) patches, on the other hand, direct and defect-mediated electron recombination from the oxide conduction to the valence band is responsible for plasmon excitations in the STM cavity. Given the different excitation mechanisms, Cu2O and Cu3O2 oxide regions become distinguishable in bias-dependent STM luminescence maps with nanometre precision. We expect this optical contrast scheme to be applicable whenever blends of dielectric materials with different band gaps coexist on the surface.
Design of Commercial Building by Considering Various Structural Orientations
Authors: Reddy Marri Srinivasa , Gnana Kumar S. , Reddy Tallapureddy Subba 
Published: August 2021

Abstract
Building introduction is a critical structure thought, mostly concerning based on the wind and radiation from the sun. In transcendently hot humidity based locations like Malaysia where the sunlight is existing overall year which gets daylight all year around, structures of the buildings have to be situated to limit sunlight based gain and amplify regular ventilation. This paper represents an investigate on the impact of building introduction based on the absorption of sun radiation at outside divider, shifter zone proportion at the coated window and regular ventilation during the working in humidity locations. The Raman building is located in AEC Campus, Penang which is a mechanical business building, constructed in the form of east west ways. For the contextual investigation the both east and west bearing rooms were considered. By utilizing the lumberjack BABUC/M, the contrast among the “in” and “out” speed and temperature of the air in both of the rooms were calculated which information’s have been dissected and researched. The outcome of this study demonstrated that the indoor temperature is expanded based on the impact of the east window which is better than west window. The west window is identified as suitable for the ventilated or unventilated rooms.