bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection criteria for assembling a pediatric cancer predisposition syndrome gene panel
Authors: Byrjalsen Anna , Diets Illja J. , Bakhuizen Jette , Hansen Thomas van Overeem , Schmiegelow Kjeld , Gerdes Anne-Marie , Stoltze Ulrik , Kuiper Roland P. , Merks Johannes H. M. , Wadt Karin , Jongmans Marjolijn 
Published: June 2021

AbstractIncreasing use of genomic sequencing enables standardized screening of all childhood cancer predisposition syndromes (CPS) in children with cancer. Gene panels currently used often include adult-onset CPS genes and genes without substantial evidence linking them to cancer predisposition. We have developed criteria to select genes relevant for childhood-onset CPS and assembled a gene panel for use in children with cancer. We applied our criteria to 381 candidate genes, which were selected through two in-house panels (n = 338), a literature search (n = 39), and by assessing two Genomics England’s PanelApp panels (n = 4). We developed evaluation criteria that determined a gene’s eligibility for inclusion on a childhood-onset CPS gene panel. These criteria assessed (1) relevance in childhood cancer by a minimum of five childhood cancer patients reported carrying a pathogenic variant in the gene and (2) evidence supporting a causal relation between variants in this gene and cancer development. 138 genes fulfilled the criteria. In this study we have developed criteria to compile a childhood cancer predisposition gene panel which might ultimately be used in a clinical setting, regardless of the specific type of childhood cancer. This panel will be evaluated in a prospective study. The panel is available on (pediatric-cancer-predisposition-genepanel.nl) and will be regularly updated.
Are Autistic and Alexithymic Traits Distinct? A Factor-Analytic and Network Approach
Authors: Cuve Hélio Clemente , Murphy Jennifer , Hobson Hannah , Ichijo Eri , Catmur Caroline , Bird Geoffrey 
Published: June 2021

AbstractDespite the heterogeneity in autism, socioemotional difficulties are often framed as universal. Increasing evidence, however, suggests that socioemotional difficulties may be explained by alexithymia, a distinct yet frequently co-occurring condition. If, as some propose, autistic traits are responsible for socioemotional impairments, then alexithymia may itself be a symptom of autism. We aimed to determine whether alexithymia should be considered a product of autism or regarded as a separate condition. Using factor-analytic and network approaches, we provide evidence that alexithymic and autistic traits are distinct. We argue that: (1) models of socioemotional processing in autism should conceptualise difficulties as intrinsic to alexithymia; and (2) assessment of alexithymia is crucial for diagnosis and personalised interventions.
Evaluation of Single Event Upset Susceptibility of FinFET-based SRAMs with Weak Resistive Defects
Authors: Copetti Thiago , Cardoso Medeiros Guilherme , Taouil Mottaqiallah , Hamdioui Said , Bolzani Poehls Letícia , Balen Tiago 
Published: June 2021

AbstractFin Field-Effect Transistor (FinFET) technology enables the continuous downscaling of Integrated Circuits (ICs), using the Complementary Metal-Oxide Semiconductor (CMOS) technology in accordance with the More Moore domain. Despite demonstrating improvements on short channel effect and overcoming the growing leakage problem of planar CMOS technology, the continuity of feature size miniaturization tends to increase sensitivity to Single Event Upsets (SEUs) caused by ionizing particles, especially in blocks with higher transistor densities such as Static Random-Access Memories (SRAMs). Variation during the manufacturing process has introduced different types of defects that directly affect the SRAM's reliability, such as weak resistive defects. As some of these defects may cause dynamic faults, which require more than one consecutive operation to sensitize the fault at the logic level, traditional test approaches may fail to detect them, and test escapes may occur. These undetected faults, associated with weak resistive defects, may affect the FinFET-based SRAM reliability during its lifetime. In this context, this paper proposes to investigate the impact of ionizing particles on the reliability of FinFET-based SRAMs in the presence of weak resistive defects. Firstly, a TCAD model of a FinFET-based SRAM cell is proposed allowing the evaluation of the ionizing particle’s impact. Then, SPICE simulations are performed considering the current pulse parameters obtained with TCAD. In this step, weak resistive defects are injected into the FinFET-based SRAM cell. Results show that weak defects can positively or negatively influence the cell reliability against SEUs caused by ionizing particles.
Simple periprocedural precautions to reduce Doppler microembolic signals during AF ablation
Authors: Christoph Marian , Poitz David , Pfluecke Christian , Forkmann Mathias , Huo Yan , Gaspar Thomas , Schoen Steffen , Ibrahim Karim , Quick Silvio , Wunderlich Carsten 
Published: June 2021

Abstract
Background
Doppler microembolic signals (MES) occur during atrial fibrillation ablation despite of permanent flushed transseptal sheaths, frequent controls of periprocedural coagulation status and the use of irrigated ablation catheters

Purpose
To investigate the number and type of MES depending on the procedure time, prespecified procedure steps, the activated clotting time (ACT) during the ablation procedure and the catheter contact force.

Methods
In a prospective trial, 53 consecutive atrial fibrillation patients underwent pulmonary vein isolation by super-irrigated “point-by-point” ablation. All patients underwent a periinterventional, continuous transcranial Doppler examination (TCD) of the bilateral middle cerebral arteries during the complete ablation procedure.

Results
An average of 686±226 microembolic signals were detected by permanent transcranial Doppler. Thereby, 569±208 signals were differentiated as gaseous and 117±31 as solid MES. The number of MES with regard to defined procedure steps were as follows: gaseous: [transseptal puncture, 26 ± 28; sheath flushing, 24±12; catheter change, 21±11; angiography, 101±28; mapping, 9±9; ablation, 439±192; protamine administration, 0±0]; solid: [transseptal puncture, 8±8; sheath flushing, 9±5; catheter replacement, 6±6; angiography, not measurable; mapping, 2±5; ablation, 41±22; protamine administration, 0±0]. Significantly less MES occurred with shorter procedure time, higher ACT and the use of tissue contact force monitoring.

Conclusion
The current study demonstrates that during atrial fibrillation ablation using irrigated, “point-by-point” RF ablation, masses of microembolic signals are detected in transcranial ultrasound especially in the period of RF current application. The number of MES depends on the total procedure time and the reached ACT during ablation. The use of contact force monitoring might reduce MES during RF ablation.
Treatment success and its predictors as well as the complications of catheter ablation for atrial fibrillation in a high-volume centre
Authors: Numminen Anna , Penttilä Tero , Arola Olli , Inkovaara Jaakko , Oksala Niku , Mäkynen Heikki , Hernesniemi Jussi 
Published: June 2021

Abstract
Purpose
Catheter ablation for atrial fibrillation (AF) is a standard procedure for maintaining sinus rhythm. The aim of this study was to evaluate treatment success and its predictors and to provide quality control data on complications and redo operations in a centre with an initially a low but currently high annual volume.

Methods
Data on patients (n = 1,253) treated with catheter ablation for AF in Tays Heart Hospital between January 2010 and May 2018 was evaluated (n = 1178 ablation-naïve patients and n = 1514 AF ablations). Comprehensive data on patient characteristics, treatment results, redo operations and complications were collected. Treatment success (maintenance of sinus rhythm at 1 year) was evaluated among patients residing within the hospital district (45% of the entire study population).

Results
Treatment success was observed in approximately 62.9% of the ablation-naïve patients. Preoperative predictors of treatment success were paroxysmal AF type, previous use of antiarrhythmic drugs, left atrium diameter and age. The experience at the centre did not associate with the 1-year outcome. A relapse during the first 3-month blanking period was associated with a nine-fold risk of failure at 1 year (unadjusted OR 9.1, 95% CI 5.5–15.1, p < 0.001). The major complication rate was 4.5% (68/1514) with no deaths. Ten percent of the patients needed a redo procedure within the first year.

Conclusions
Patient-related factors are the most significant predictors of treatment success. A relapse during a 3-month blanking period is associated with a very high risk of failure at 1 year.
Lagrangian relaxation based heuristics for a chance-constrained optimization model of a hybrid solar-battery storage system
Authors: Singh Bismark , Knueven Bernard 
Published: June 2021

AbstractWe develop a stochastic optimization model for scheduling a hybrid solar-battery storage system. Solar power in excess of the promise can be used to charge the battery, while power short of the promise is met by discharging the battery. We ensure reliable operations by using a joint chance constraint. Models with a few hundred scenarios are relatively tractable; for larger models, we demonstrate how a Lagrangian relaxation scheme provides improved results. To further accelerate the Lagrangian scheme, we embed the progressive hedging algorithm within the subgradient iterations of the Lagrangian relaxation. We investigate several enhancements of the progressive hedging algorithm, and find bundling of scenarios results in the best bounds. Finally, we provide a generalization for how our analysis extends to a microgrid with multiple batteries and photovoltaic generators.
The role of Interleukin-1 receptor antagonist as a treatment option in calcium pyrophosphate crystal deposition disease
Authors: Altomare Alberto , Corrado Addolorata , Maruotti Nicola , Cici Daniela , Cantatore Francesco Paolo 
Published: June 2021

AbstractCalcium Pyrophosphate Crystal Deposition (CPPD) disease is characterized by the deposition of calcium pyrophosphate crystals in the cartilage. In most cases, it can manifest as a subclinical condition named chondrocalcinosis, often revealed by joint x-ray examination. In other cases, deposition can cause flares of arthritis, known as acute CPP crystal arthritis. In the last few years, many pathogenic pathways have been discovered. Interleukin-1 (IL-1) plays a key role in the pathogenesis of CPPD disease, both as a mediator of inflammatory response to crystals and as a promoter of damage to articular cartilage. In this review, we investigated the role of IL-1R inhibitor, such as Anakinra, as an alternative to the various therapeutic strategies for CPPD disease, especially among patients resistant to traditional treatment with NSAIDs, corticosteroids and colchicine.
Local Candidates, Place-Based Identities, and Electoral Success
Authors: Schulte-Cloos Julia , Bauer Paul C. 
Published: May 2021

AbstractWhile a large body of literature empirically documents an electoral advantage for local candidates, the exact mechanisms accounting for this effect remain less clear. We integrate theories on the political geography of candidate-voter relations with socio-psychological accounts of citizens’ local attachment, arguing that citizens vote for candidates from their own local communities as an expression of their place-based identity. To test our argument, we exploit a unique feature of the German mixed-member electoral system. We identify the causal effect of candidates’ localness by relying on within-electoral-district variation coupled with a geo-matching strategy on the level of municipalities ($$\hbox {N}=11175$$

N
=
11175

). The results show that voters exhibit a strong bias in favor of local candidates even when they are not competitive. More than only expecting particularistic benefits from representatives, citizens appear to vote for candidates from their own local community to express their place-based social identity.
Evaluating Others If They Stand Up for Their Moral Convictions, and Evaluating Ourselves If We Don't Stand Up
Authors: Cramwinckel Florien M. , van den Bos Kees , van Dijk Eric 
Published: June 2021

AbstractActing on one’s moral principles is not always easy. Upholding one’s moral beliefs may run counter to one’s social environment or situational demands. It may often cause people to remain silent on their convictions, while at the same time some may show the moral courage to speak out. How do people evaluate those who do stand up, and how does it affect their self-evaluations? In two experimental studies (Ns = 207 and 204), we investigated both types of evaluations. The studies demonstrate that people who failed to uphold their moral beliefs still had positive evaluations of others who showed moral courage. More specifically, pro-gay participants who went along with writing an anti-gay essay denouncing equal rights for sexual minorities had positive evaluations of another person who spoke up and refused this task. The failure to display moral courage had negative consequences for participants’ self-concepts. In Experiment 1, we show that pro-gay participants’ positive self-concepts were lowered after writing an anti-gay essay (vs. a pro-gay essay). In Experiment 2, we reveal that participants' positive self-concepts were lowered only when they were confronted with morally courageous behavior and their own failure to uphold their moral beliefs was visible to the experimenter.
Understanding variability in greenhouse gas emission estimates of smallholder dairy farms in Indonesia
Authors: Apdini Titis , Al Zahra Windi , Oosting Simon J. , de Boer Imke J. M. , de Vries Marion , Engel Bas , van Middelaar Corina E. 
Published: June 2021

Abstract
Purpose
Life cycle assessment studies on smallholder farms in tropical regions generally use data that is collected at one moment in time, which could hamper assessment of the exact situation. We assessed seasonal differences in greenhouse gas emissions (GHGEs) from Indonesian dairy farms by means of longitudinal observations and evaluated the implications of number of farm visits on the variance of the estimated GHGE per kg milk (GHGEI) for a single farm, and the population mean.

Methods
An LCA study was done on 32 smallholder dairy farms in the Lembang district area, West Java, Indonesia. Farm visits (FVs) were performed every 2 months throughout 1 year: FV1–FV3 (rainy season) and FV4–FV6 (dry season). GHGEs were assessed for all processes up to the farm-gate, including upstream processes (production and transportation of feed, fertiliser, fuel and electricity) and on-farm processes (keeping animals, manure management and forage cultivation). We compared means of GHGE per unit of fat-and-protein-corrected milk (FPCM) produced in the rainy and the dry season. We evaluated the implication of number of farm visits on the variance of the estimated GHGEI, and on the variance of GHGE from different processes.

Results and discussion
GHGEI was higher in the rainy (1.32 kg CO2-eq kg−1 FPCM) than in the dry (0.91 kg CO2-eq kg−1 FPCM) season (P < 0.05). The between farm variance was 0.025 kg CO2-eq kg−1 FPCM in both seasons. The within farm variance in the estimate for the single farm mean decreased from 0.69 (1 visit) to 0.027 (26 visits) kg CO2-eq kg−1 FPCM (rainy season), and from 0.32 to 0.012 kg CO2-eq kg−1 FPCM (dry season). The within farm variance in the estimate for the population mean was 0.02 (rainy) and 0.01 (dry) kg CO2-eq kg−1 FPCM (1 visit), and decreased with an increase in farm visits. Forage cultivation was the main source of between farm variance, enteric fermentation the main source of within farm variance.

Conclusions
The estimated GHGEI was significantly higher in the rainy than in the dry season. The main contribution to variability in GHGEI is due to variation between observations from visits to the same farm. This source of variability can be reduced by increasing the number of visits per farm. Estimates for variation within and between farms enable a more informed decision about the data collection procedure.
Jaws of Platynereis dumerilii: Miniature Biogenic Structures with Hardness Properties Similar to Those of Crystalline Metals
Authors: Zelaya-Lainez Luis , Balduzzi Giuseppe , Lahayne Olaf , Ikeda Kyojiro N. , Raible Florian , Herzig Christopher , Nischkauer Winfried , Limbeck Andreas , Hellmich Christian 
Published: June 2021

AbstractNanoindentation, laser ablation inductively coupled plasma mass spectroscopy and weighing ion-spiked organic matrix standards revealed structure-property relations in the microscopic jaw structures of a cosmopolitan bristle worm,Platynereis dumerilii. Hardness and elasticity values in the jaws’ tip region, exceeding those in the center region, can be traced back to more metal and halogen ions built into the structural protein matrix. Still, structure size appears as an even more relevant factor governing the hardness values measured on bristle worm jaws across the generaPlatynereis,GlyceraandNereis. The square of the hardness scales with the inverse of the indentation depth, indicating a Nix-Gao size effect as known for crystalline metals. The limit hardness for the indentation depth going to infinity, amounting to 0.53 GPa, appears to be an invariant material property of the ion-spiked structural proteins likely used by all types of bristle worms. Such a metal-like biogenic material is a major source of bio-inspiration.
Design of Functionalized Lobed Particles for Porous Self-Assemblies
Authors: Gorai Biswajit , Rocha Brunno C. , Vashisth Harish 
Published: June 2021

AbstractColloidal particles fabricated with anisotropic interactions have emerged as building blocks for designing materials with various nanotechnological applications. We used coarse-grained Langevin dynamics simulations to probe the morphologies of self-assembled structures formed by lobed particles decorated with functional groups. We tuned the interactions between the functional groups to investigate their effect on the porosity of self-assembled structures formed by lobed particles with different shapes (snowman, dumbbell, trigonal planar, tetrahedral, square planar, trigonal bipyramidal, and octahedral) at different temperatures. The dumbbell, trigonal planar, and square planar shaped particles, with planar geometries, form self-assembled structures including elongated chains, honeycomb sheets, and square sheets, respectively. The particles with non-planar geometries (tetrahedral, trigonal bipyramidal, and octahedral) self-assemble into random aggregate morphologies. The structures formed by trigonal bipyramidal and octahedral particles exhibit smaller and homogeneous pores compared to the structures formed by trigonal planar and square planar particles. The porosity in self-assembled structures is substantially enhanced by the functionalization of particles.
Multiscale Contextual Poverty in the Netherlands: Within and Between-Municipality Inequality
Authors: Petrović Ana , Manley David , van Ham Maarten 
Published: June 2021

AbstractContextual poverty refers to high proportions of people with a low income in a certain (residential) space, and it can affect individual socioeconomic outcomes as well as decisions to move into or out of the neighbourhood. Contextual poverty is a multiscale phenomenon: Poverty levels at the regional scale reflect regional economic development, while meso-scale concentrations of poverty within cities are related to city-specific social, economic and housing characteristics. Within cities, poverty can also concentrate at micro spatial scales, which are often neglected, largely due to a lack of data. Exposure to poverty at lower spatial scales, such as housing blocks and streets, is important because it can influence individuals through social mechanisms such as role models or social networks. This paper is based on the premise that sociospatial context is necessarily multiscalar, and therefore contextual poverty is a multiscale problem which can be better understood through the inequality within and between places at different spatial scales. The question is how to compare different spatial contexts if we know that they include various spatial scales. Our measure of contextual poverty embraces 101 spatial scales and compares different locations within and between municipalities in the Netherlands. We found that the national inequality primarily came from the concentrations of poverty in areas of a few kilometres, located in cities, which have different spatial patterns of contextual poverty, such as multicentre, core-periphery and east–west. In addition to the inequality between municipalities, there are considerable within-municipality inequalities, particularly among micro-areas of a few hundred metres.
The locomotory apparatus and paraxial swimming in fossil and living marine reptiles: comparing Nothosauroidea, Plesiosauria, and Chelonioidea
Authors: Krahl Anna 
Published: June 2021

AbstractThe terrestrial origins of the diapsid Sauropterygia and Testudines are uncertain, with the latter being highly controversially discussed to this day. For only 15 Ma, Nothosauroidea lived in shallow-marine seas of the Triassic. Contrastingly, the pelagic Plesiosauria evolved in the Late Triassic, dispersed globally, and inhabited the oceans of the Jurassic and Cretaceous for approximately 135 Ma. Since the Cretaceous (~ 100 Ma), Chelonioidea, the modern sea turtles, have populated the oceans. All three groups evolved aquatic paraxial locomotion. Nothosaurs swam with their foreflippers, supported by the swimming tail. Plesiosaurs are the only tetrapods to have ever evolved four hydrofoil-like flippers. The plesiosaur flipper beat cycle has been debated for nearly two centuries. The different proposed locomotory styles (rowing, rowing-flight, underwater flight) are discussed in this review. A fourth gait that is employed byCarettochelys insculpta, which combines rowing and flying, is introduced. The osteology of the locomotory apparatus of nothosaurs and plesiosaurs is reviewed and compared to that of extant underwater-flying Chelonioidea. In conclusion, underwater flight remains the favoured locomotory style for plesiosaurs. Also, the review reveals that nothosaur locomotion has largely remained unstudied. Further, our understanding of joint morphologies and mobilities of the foreflipper in nothosaurs, plesiosaurs, and even recent sea turtles, and of the hindflipper in plesiosaurs, is very limited. It is crucial to the discussion of locomotion, to find out, if certain limb cycles were even possible, as evidence seems to point to the improbability of a rowing motion because of limited humerus and femur long axis rotation in plesiosaurs.