bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Biological Activity of Curcuma longa Methanol Extract and Its Antibacterial effect on Staphylococcus aureus
Authors: Ogbonna Covenant , Özgör Erkay 
Published: April 2021

Abstract
Plants are known to possess enormous profound benefits, which if well incorporated in daily living have the potential to influence our health in ways unexpected. Significant progress has been made concerning the anti-oxidative and anti-cancerous effect of bioactive components in food products, worthy of note in the curcuminoids derived from turmeric (Curcuma longa) rhizomes. Therefore, to this end, this research aims to describe succinctly the phytocomponents, antioxidant activity and anti-microbial activity of turmeric methanol extract. The zones of inhibition were measured after plating on a Mueller Hinton agar plate and compared to the standards penicillin G and chloramphenicol. Chloramphenicol used as a positive control was found to be most effective on Staphylococcus aureus while Curcuma longa methanol extract and penicillin G were found to have the same microbial inhibition due to the negative control. Compared to the IC50 values of Ascorbic acid which was 5 mg/ ml, Curcuma longa methanol extract had a lower IC50 value is 3.2 mg/ml which according to previous literature is a good one given that lower IC50 values indicate great antioxidant activity. It was gathered by the observation that the qualitative extraction of Curcuma longa using methanol shows the presence of varying chemical components such as AR-tumerone, arachinsaeure, alpha-tumerone amongst others. Research data suggest that ar-turmerone has the potential to promote the positive and negative proliferation of tumor cell lines. As a result, Curcuma longa has high potential to be developed into an antibiotic against Methicillin-resistant Staphylococcus aureus and other clinically important bacterial strains in future.
Comparison of three diagnostic methods in the diagnosis of cryptosporidiosis and gp60 subtyping of Cryptosporidium parvum in diarrheic calves in Central Anatolia Region of Turkey
Authors: Yildirim Alparslan , Sevinc Ferda , Onder Zuhal , Duzlu Onder , Ekici Ozlem Derinbay , Isik Nermin , Ciloglu Arif , Simsek Emrah , Yetismis Gamze , Inci Abdullah 
Published: April 2021

Abstract
The aim of this study was to compare three diagnostic methods for the diagnosis of cryptosporidiosis and to detect subtypes ofCryptosporidium parvum by sequences analyses of gp60 gene in diarrheic calves in several herds in Konya province located in Central Anatolia Region of Turkey. Fecal samples were collected from a total of 194 pre-weaned calves (n=158, ≤15 days old, and n=36, 15 to 40 days old), with diarrhoea. For comparative diagnosis, all samples were examined by modified Ziehl-Neelsen staining of fecal smears for the presence of oocyst, nested PCR-RFLP of SSU rRNA and TaqMan qPCR for the detection of Cryptosporidium DNA. A total of 92 (47.4%) and 104 (53.6%) out of the examined samples were found positive by microscopic examination and molecular tools, respectively. The diagnostic sensitivity and specificity of microscopic identification were determined as 88.5% and 100.0%, respectively compared to molecular assays. Cryptosporidium parvum was the only detected species in all positive samples by species-specific qPCR and nested PCR-RFLP assays. Species identifications were further confirmed by sequence analyses of the SSU rRNA PCR products. There was no statistically significant difference in C. parvum prevalence between early pre-weaned calves and calves older than 15 days. The sequence analyses of the gp60 gene of C. parvum isolates revealed a one subtype IIaA13G2R1 belonging to zoonotic family IIa in diarrheic calves
Yoga as an Adjuvant for Cancer Patients in India
Authors: Chakrabarty Jyothi , Vidyasagar M S 
Published: April 2021

Abstract
Though Yoga has originated in India, its scientific use to alleviate the sufferings of cancer patients in India is thin. There are very few published studies on yoga intervention for cancer patients from India. The objective of this review was to analyze the studies that have used yoga as an adjuvant for cancer treatment. Literature searches were made in PubMed, CINAHL, Google Scholar, Proquest and Science Direct for retrieving the related studies. Data were analyzed according to the objective. The compiled results show that yoga and pranayama interventions for cancer patients in India focused mostly on psychological aspects like anxiety and depression. Few studies have explored deep into the mechanisms by which the interventions produce the desired effects. Only very few researchers have analyzed the genetic or biochemical changes that occur in the human body as a result of practicing yoga. Currently, the focus is generally on breast cancer. Researches with yoga and pranayama as an adjuvant for other cancers also need to be experimented.
Acinar cell carcinoma in childhood: A case report of a very rare tumor
Authors: Pourtsidis Apostolos , Papachristidou Smaragda , Achilleos Orthodoxos , Mirza Darius , Servitzoglou Marina , Doganis Dimitrios , Kapetaniou Konstantina , Nikita Maria , Magkou Evgenia , Ptochis Nikolaos , Papazoglou Anastasia , Moutafi Antonia , Pantalos Georgios , Michail Aikaterini , Baka Margarita 
Published: April 2021

Abstract

Introduction
Pancreatic tumors are reported rarely in childhood and represent an extremely rare entity in Pediatric Oncology. One of the least common types of pediatric pancreatic tumor is acinar cell carcinoma (ACC). We aim to present a rare case of ACC and the difficulties we faced during diagnosis and treatment.

Patient and Methods
An 8-year old girl presented with jaundice. Workup revealed a tumor originating from the head of the pancreas with multiple metastatic lesions in her liver. Evaluation of tumor markers revealed elevated levels of AFP. Pathology report was indicative of acinar cell carcinoma of the pancreas.

Results
After consulting the EXPeRT group (European Cooperative Study Group for Pediatric Rare Tumors), chemotherapy was initiated. Partial response was observed after the first 4 courses with decrease of AFP levels. While planning her surgery, AFP elevated and a second-line course of chemotherapy was administered. Our patient underwent Whipple’s Duodenopancreatectomy with partial metastasectomy. Although the postoperative period was uneventful, AFP continued to rise even after postoperative chemotherapy was administered. There were signs of metastatic disease progression. Our patient received a third-line regimen with no improvement. She received local radiotherapy and a next-line chemotherapy course. Local relapse and metastatic disease progression placed our patient in palliative care. She passed away nine months after the initial diagnosis.

Conclusions
Acinar cell carcinoma of the pancreas is a rare type of pediatric cancer with very challenging diagnosis and treatment. Cooperation at the European level and multicenter management of those rare cases is vital for the optimum outcome.
Targeted therapy in advanced desmoid tumors: Current perspectives
Authors: Mohammed Amrallah A. , EL-Tanni Hani , EL-Khatib Hani M. 
Published: April 2021

Abstract

Background
Desmoid tumors/aggressive fibromatosis (DTs/AF) are cytological bland fibrous neoplasms originating from the musculoaponeurotic structures throughout the body. The exact cause still remains unknown, however, they may present sporadically or as a manifestation of a hereditary syndrome called familial adenomatous polyposis (FAP). Although they lack the capacity to establish metastases, DTs/AF may be devastated and occasionally fatal. As a result of the heterogeneity of DTs/AF, treatment needs to be individualized to improve local tumor control and maintain patients’ quality of life. Therefore, after a multidisciplinary approach, all treatment options should be discussed with patients. Where systemic chemotherapy has been shown to be unsuccessful with marked side effects in case of advanced DTs/AF, new therapeutic options are needed.

Methods
A Medline search was conducted and published articles in different studies from 2000 to the present were reviewed.

Conclusion
More research is needed to illustrate both the prognostic and predictive factors of the targeted therapy and the value of their combinations with or without other treatment modalities to get the best result for the treatment of advanced DTs/AF.
17. The State of Belle Park
Authors: Peters Garnet , Oliver Nadene , Oswald Sean , Rosenblat Howard 
Published: April 2021

Our group used the Belle Park Golf course, located at 713 Montreal Street, as our project site. The course is located on top of a pre-existing dump that served as the city’s waste disposal site between the early 1950’s until 1974, it still shows signs of leachate seepage. The wildlife issue we explored is the effect of this leachate on the surrounding ecosystem, including tree species, fish and mammals. We researched case studies in similar situations that have been done in the past as a base for our understanding. The community entity are working with is the Environment Division of the City of Kingston, in charge of monitoring the hybrid poplar trees planted along the fairways. They are used as a means to extract contaminants from the soil, based on their proven ability for rapid growth. We will evaluate the effectiveness of this technique along with the vertical leachate extraction wells on site. Also, our group hopes to obtain the history of the water sample data that is collected from monitoring wells around the site for our analyses and interpretation. The latest budget information shows that the golf course lost $203,000 last year. This has prompted city council to reconsider the future of the property and open the doors for new innovative ideas. As part of our project we hope to come up with a sustainable solution that preserves the natural habitat and serves the community, such as a park.
21. Invasion of Asian Carp in the Great Lakes
Authors: Smrekar Kassandra , Tanaka Shingo , Williams Lavie 
Published: April 2021

A recent threat posed to the Great Lakes and adjoining waterways is the Asian Carp. This large bodied fish originated from Asia and was first imported to the North American between 1960 to 1970. Their migration northward through the Mississippi River eliminated native freshwater species through competition of habitat and food resources. It is imperative to focus on the potential invasion of the Asian Carp because the risk assessment is high that the carp would eliminate all native species. Currently the carp are at the border of entering Lake Michigan, which would then provide access to the rest of the freshwater regions in the surrounding area. Ultimately, the loss of lake biodiversity is the fundamental problem and is coupled with economic issues. Bowfin Environmental Consulting INC and various invasive species awareness programs have been utilized to provide guidance on undertaking a project that involves an aggressive invasive species. The challenge faced will be to determine a method in which to prevent the invasion of Asian Carp. Examining their migration patterns, importation laws of live fish, and the policies of invasive species, will provide insight on the approach that should be taken to eliminate the threat of Asian Carp. It is also important to analyze which native species are most susceptible to becoming extinct. Overall, the intention is not only to increase government, scientific, and public awareness of this issue, but also to provide methods that can be implemented to prevent and eradicate the spread of Asian Carp in North American waterways.
Novel Integration of Administrative Pharmacy Residents in a Management Course
Authors: Ford James , Rotzenberg Katherine , Mott David 
Published: April 2021

Background: Management skills are an essential component of a pharmacy graduate’s abilities for successful practice. Although pharmacy education standards require that students have a working knowledge of management principles, students often do not see the value in management and business courses. One innovative approach is restructuring course content using case examples and real-world experiences to improve student understanding of finance and management principles.
Innovation: Two specific changes were implemented in a second year (P2) management and finance course to improve the relevance of business principles. Course content was organized around current pharmacy service cases from a variety of practice settings and supported by the value of problem-based learning. Post-graduate year 1 (PGY-1) administrative pharmacy residents were engaged as course teaching assistants (TAs) who brought real-world experiences into the class. An analysis of pre- and post-course voluntary surveys, course evaluations, and TA evaluations assessed the impact of the course redesign.
Findings: The course redesign achieved its intended goal of improving student-perceived course relevance. This was shown through statistically significant improvements in course evaluations that were intended to measure student perception of pharmacy management and its relevance in their future career. Student completed TA evaluations showed that those who reported their TA shared real-world applications had higher confidence in applying course concepts and greater understanding of course materials.
Conclusions: Administrative pharmacy residents were successfully integrated into a pharmacy management course redesign, resulting in improved student perceptions of course relevance.
EFICÁCIA DA REVASCULARIZAÇÃO NA FORMAÇÃO DO ÁPICE RADICULAR EM PACIENTES COM RIZOGÊNESE INCOMPLETA: UMA REVISÃO INTEGRATIVA
Authors: REIA Verônica Caroline Brito , MOLITOR Pedro , PIRAS Fernanda Furtado , CAMARGO Marcelo Ueti de , MAGRO Miriam Graziele 
Published: April 2021

Objetivos: Verificar a eficácia da revascularização para induzir a continuidade de formação do ápice radicular em pacientes com rizogênese incompleta. Metodologia: A estratégia de busca foi aplicada nas bases de dados eletrônicas PubMed, Embase, Web of Science e LILACS, sendo selecionados quatro artigos publicados entre 2011 e 2021. Resultados: Um total de 27 pacientes diagnosticados com necrose pulpar foi incluído, de ambos os sexos. Os testes de percussão, térmico e elétrico no exame clínico foram realizados em 4 pacientes. Todos os pacientes fizeram radiografia periapical para análise inicial. O tratamento endodôntico foi realizado com indução do sangramento apical do canal radicular para revascularização em todos os estudos. No acompanhamento de até 4 anos, observou-se, radiograficamente, aumento do comprimento e espessura radicular, diminuição e posterior desaparecimento da radioluscência periapical, estreitamento do ápice radicular, desenvolvimento radicular e redução da lesão periapical. Conclusão: A revascularização permite que, mesmo após o estímulo para indução de sangramento, a região periapical continue a formação radicular por mais tempo quando comparada a outros materiais endodônticos.

THE EFFECTIVENESS OF REVASCULARIZATION ON ROOT APEX FORMATION IN PATIENTS WITH IMMATURE PERMANENT TEETH: AN INTEGRATIVE REVIEW

ABSTRACT
Objectives: To verify the effectiveness of revascularization to induce further root apex formation in patients with immature permanent teeth. Method: A searching strategy was performed at PubMed, Embase, Web of Science, and LILACS electronic database, four articles issued between 2011 and 2021 were screened. Results: A total of 27 patients diagnosed with pulp necrosis were included, both genders. Percussion, electric, and thermal pulp testing were performed for clinical examination in those 4 patients. All the patients had a periapical x-ray taken for initial analysis. The endodontic treatment was performed with the apex-induced bleeding into the root canal for the revascularization in all the studies. At a 4-year follow-up it was observed, radiographically, an increase in root length and thickness, and afterward the periapical radiolucency disappearance, the root apex narrowing, root growing, and the periapical lesion reduction. Conclusion: Revascularization enables, even after the stimulus for bleeding induction, the periapical region to further continue the root formation when compared to other endodontic materials.

Descriptors: Endodontics. Pulp Necrosis. Tooth Apex.
Gambaran Infeksi Nontuberculous Mycobacteria (NTM) pada Penderita Suspek TB Paru Menggunakan Multiplex PCR (MPCR)-Universal Lateral Flow Assay (ULFA) Kit
Authors: Akbar Putri Wulan , Iskandar Agustin , Astuti Tri Wahju , Indriana Kristin 
Published: April 2021

Infeksi paru akibat Nontuberculous Mycobacteria (NTM) dan Mycobacterium tuberculosis (MTB) dapat memberikan gambaran klinis yang serupa sehingga berpotensi menyebabkan kesalahan diagnosis dan terapi. Pemeriksaan Multiplex PCR (MPCR)-Universal Lateral Flow Assay (ULFA) merupakan pemeriksaan berbasis molekuler untuk mendeteksi gen rpoB, IS1660 dan mtp40 yang dapat digunakan untuk membedakan infeksi NTM dari infeksi TB. Tujuan: Mendapatkan gambaran infeksi NTM menggunakan MPCR-ULFA pada penderita terduga TB paru. Metode: Penelitian ini merupakan studi deskriptif dengan pendekatan potong lintang yang dilaksanakan sejak April sampai Juli 2019. Sebanyak 39 sampel sputum dari pasien terduga TB paru dari RSUD Kanjuruhan Kepanjen, Kabupaten Malang diperiksakan apusan BTA, GeneXpert dan MPCR-ULFA. Hasil: Sebanyak 5 sampel (12,8%) sputum dari pasien terduga TB paru terdeteksi sebagai NTM positif menggunakan pemeriksaan MPCR-ULFA. Empat dari lima sampel (80%) tersebut memiliki kesesuaian dengan hasil GeneXpert dan apusan BTA, yakni MTB negatif. Pemeriksaan molekuler baik GeneXpert maupun MPCR-ULFA keduanya mendeteksi keberadaan gen rpoB dari Mycobacterium. Metode MPCR-ULFA mengamplifikasi 3 gen target sekaligus (IS1660, mtp40 dan rpoB) sehingga dapat mendeteksi infeksi NTM atau MTB. Simpulan: Prevalensi NTM pada pasien terduga TB paru di RSUD Kanjuruhan Kepanjen menggunakan MPCR-ULFA mencapai 12,8%. Sebanyak 80% dari NTM positif memiliki hasil pemeriksaan GeneXpert dan apusan BTA negatif.Kata kunci: GeneXpert, MPCR-ULFA, NTM, suspek TB paru
Efektifitas Metode William's Flexion dan Yoga Terhadap Intensitas Nyeri Punggung Bawah pada Ibu Hamil Trimester III di Kota Tanjungpinang Tahun 2019
Authors: Rahmadona Rahmadona , Batubara Kartika Sri Dewi 
Published: April 2021

Nyeri punggung bawah pada kehamilan merupakan nyeri pada area lumbosacral. Hal ini sangat mengganggu aktivitas harian ibu hamil yang apabila tidak ditangani dapat menyebabkan kualitas hidup ibu hamil menjadi buruk. Beberapa terapi non farmakologis seperti latihan William’s flexion dan yoga dapat diupayakan mengatasi keluhan nyeri punggung bawah pada kehamilan.Tujuan: Menentukan efektifitas metode William’s flexion dan yoga terhadap intensitas nyeri punggung bawah pada ibu hamil trimester III di Kota Tanjungpinang tahun 2019. Metode: Penelitian ini adalah pra eksperimen dengan two group pre test post test design terhadap 60 sampel yang terbagi dua kelompok yaitu kelompok William’s flexion dan yoga. Data dikumpulkan dari Agustus hingga Oktober 2019, kemudian diukur menggunakan skala ukur numerik . Analisis data menggunakan t-test dependent dan independent. Hasil: Penelitian menunjukkan uji rerata dalam tiap kelompok perlakuan menunjukkan hasil bermakna (p=0,000) dengan selisih rerata penurunan intensitas nyeri punggung bawah pada kelompok William’s flexion sebesar 1,27 dan kelompok yoga sebesar 2,50. Uji rerata antar kelompok perlakuan juga menunjukan hasil bermakna(p=0,000). Simpulan: Metode William’s flexion dan yoga efektif menurunkan intensitas nyeri punggung bawah. Latihan yoga memberi penurunan intensitas nyeri lebih besar daripada latihan William’s flexion sehingga kedua metode ini bisa dipakai untuk mengatasi keluhan nyeri punggung bawah pada ibu hamil trimester III.Kata kunci: nyeri punggung bawah, William’s flexion, yoga
PELATIHAN KONSEP ANALISIS LAPORAN KEUANGAN KEPADA UMKM
Authors: Mayangsari Sekar , Banjarnahor Erliana , Lenggogeni Lenggogeni Jakarta , Nasution Kevin M. Pransilva 
Published: April 2021

Abstrak:Tujuan dari pelaksanaan kegiatan Pengabdian kepada Masyarakat (PkM) ini membantu UMKM membuat laporan keuangan yang mengacu kepada Standar Akuntansi Keuangan Entitas tanpa Akuntanbilitas Publik (SAK-ETAP) serta memahami konsep analisis laporan keuangan. Kegiatan PkM ini yang merupakan kegiatan yang berkesinambungan. Dalam pelatihan, metode dilakukan dengan daring dengan menggunakan aplikasi zoom. Dalam pelatihan dilakukan diskusi dengan peserta yang dipandu oleh moderator melalui aplikasi zoom. Dilakukan pula umpan balik terhadap peserta dengan kuesioner melalui google form. Hasil evaluasi dari pelaksanaan PkM menunjukan bahwa peserta PkM menyatakan puas terhadap kegiatan, dan tujuan PkM tercapai dimana peserta memperoleh manfaat berupa pengetahuan, pemahaman dan ketrampilan tentang konsep analisis laporan keuangan UMKM. Abstract:The purpose of implementing this Pengabdian kepada Masyarakat (PkM) activity is to help MSMEs create financial reports that refer to the Financial Accounting Standards Entities without Public Accountability (SAK-ETAP) and understand the concept of financial statement analysis. This PkM activity is ongoing. During the training, discussions were held with participants guided by a moderator through the zoom application. Feedback was also carried out to participants with a questionnaire via a google form. The results of the evaluation of the implementation of PkM show that the PkM participants expressed satisfaction with the activities, and the PkM objectives were achieved where the participants benefited in the form of knowledge, understanding, and skills about the concept of analysis of SME financial statements.
pengaruh penekanan pellet silika terhadap porositas dan permeabilitas
Authors: Fadli Heri 
Published: April 2021

Klasifikasi silika (SiO2) dibagi dalam empat karakter dasar silika yaitu struktur kristal, dispersitas, komposisi permukaan dan porositas. Sebelumnya pasir silika ini banyak digunakan oleh industri minyak dan gas sebagai proppant (pasir frak) maupun sebagai filter air. Pilihan proppant tergantung pada jenis permeabilitas atau kekuatan butir yang dibutuhkan. Dimana proppant dengan ukuran yang lebih besar akan memberikan permeabilitas rekahan yang lebih baik, karena nilai permeabilitas akan meningkat seiring dengan bertambahnya diameter dari butiran. Penelitian ini bertujuan untuk mengetahui pengaruh penekanan pellet silika terhadap porositas dan permeabilitas. Penekanan pellet silika ini menggunakan mesin press hidrolik dengan type KW05-135 dan kapasitas 10.000 Kg. Peneliti membuat pellet silika dengan kandungan pasir silika berukuran butir seragam (100 mesh) sebanyak 8,74 g/cm3, menggunakan perekat jenis Polyethylene Glycol (PEG) 400 sebanyak 0,57 g/cm3, dan Aluminium Powder 3,42 g/cm3. Cetakan yang digunakan Mold Pellet Silika Type Alloy 410 dengan diameter dalam 27 mm, diameter luar 57 mm dan ketinggian lubang cetakan 89 mm dengan penekanan 1000 Kg, 3000 Kg, dan 5000 Kg, serta memberikan suhu sintering sebesar 1200°C. Adapun nilai porositas optimum yang diperoleh sebesar 39,25% dan nilai permeabilitas optimum yang di dapatkan sebesar 57 mD.