bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thanks, but No Thanks: Preferences towards Teleworking Colleagues in Public Organizations
Authors: Mele Valentina , Bellé Nicola , Cucciniello Maria 
Published: April 2021

Abstract
Over the last decades, one of the most significant changes in the workplaces of government agencies around the world has been the introduction of telework. The relatively scant public administration research on this innovation and on its semantic or substantive variations such as telecommuting, home-work, remote work, and smart work has examined its effects on teleworkers and only recently on non-teleworkers. However, scholars have overlooked the relational dynamics triggered by telework. This is the focus of our study. We start by connecting telework with specific features of public bureaucracies, such as control, modularity, and the separation of professional and personal life. Next, we explore through a mixed-methods design a relational dynamic overlooked by previous studies, that is, the preferences of non-teleworkers towards teleworking colleagues and the motives behind them. Results from a discrete choice experiment with over 1,000 non-teleworking public employees revealed a remarkably strong preference toward non-teleworkers. A qualitative follow-up based on semi-structured interviews found the workplace collective as the locus of the tensions caused by telework and illuminated critical issues perceived by non-teleworkers, ensuring a more fine-grained understanding of the impacts of flexible work arrangements on the functioning of public organizations.
Recent greening of grasslands in northern China driven by increasing precipitation
Authors: Di Kai , Hu Zhongmin , Wang Mei , Cao Ruochen , Liang Minqi , Wu Genan , Chen Ruru , Hao Guangcun , Zhao Yaolong 
Published: April 2021

Abstract

Aims
Recent warmer and wetter climate in northern China remains a hot topic in recent years, yet its effect on vegetation growth has not been fully understood. This study investigated the temporal change of vegetation cover and its correlations with climatic variables from 1982 to 2018 for grasslands in northern China. Our aim is to clarify whether the warmer and wetter climate in recent years drives the greening of the vegetation in this region.

Methods
We investigated the temporal dynamic of vegetation normalized difference vegetation index (NDVI) and its driving forces based on long time-series data. Piecewise regression was used to examine whether there was a turning point of the trend of NDVI and climatic variables. Pearson correlation analyses were conducted to quantify the relationship between NDVI and climatic factors. Stepwise multivariable regression was used to quantify the contributions of climate variables to the temporal variations in NDVI.

Important Findings
We found a turning point of NDVI trend in 2008, with GIMMS NDVI indicating a slight increase of 0.00022 yr−1 during 1982–2008 to an increase of 0.002 yr−1 for GIMMS NDVI during 2008–2015 and 0.0018 yr−1 for MODIS NDVI during 2008–2018. Precipitation was the predominant driver, and air temperature and vapor pressure deficit exerted a minor impact on the temporal dynamics of NDVI. Overall, our results suggest a turning point of NDVI trend, and that recent warmer and wetter climate has caused vegetation greening, which provides insights for better predicting the vegetation cover in this region under changing climate.
Bacilluspromotes invasiveness of exoticFlaveria bidentisby increasing its nitrogen and phosphorus uptake
Authors: Chen Xue , Li Qiao , Wang Yan , Chen Fengxin , Zhang Xiaoya , Zhang Fengjuan 
Published: April 2021

AbstractThe effect of exotic plants on Bacillus diversity in the rhizosphere and the role of Bacilli in exotic or native plant species remain poorly understood. Flaveria bidentis is an invasive grass in China. Setaria viridis is a native grass and occurs in areas invaded by F. bidentis. Our objectives were (i) to examine the differences in the Bacillus communities between F. bidentis and S. viridis rhizospheres soil, and (ii) to compare the effects of Bacilli from F. bidentis and S. viridis rhizospheres on the competitiveness of the invasive species. Flaveria bidentis monoculture, mixture of F. bidentis and S. viridis and S. viridis monoculture were designed in the field experiment. Bacillus diversity in their rhizosphere was analyzed using 16S rRNA. One of the dominant Bacilli in the rhizosphere soil of F. bidentis was selected to test its effect on the competitive growth of F. bidentis in a greenhouse experiment. Bacillus diversity differed in F. bidentis and S. viridis rhizosphere. Brevibacterium frigoritolerans was the dominant Bacilli in the rhizosphere of both F. bidentis and S. viridis; however, its relative abundance in the F. bidentis rhizosphere was much higher than that in the S. viridis rhizosphere. In addition, B. frigoritolerans in the F. bidentis rhizosphere enhanced the growth of the plant compared with that of S. viridis by improving the nitrogen and phosphorus levels. This study showed that F. bidentis invasion influenced Bacillus communities, especially B. frigoritolerans, which, in turn, facilitated F. bidentis growth by increasing the levels of available nitrogen and phosphorus.
Identification and characterization of novel QTL conferring internal detoxification of aluminium in soybean
Authors: Li Yang , Ye Heng , Song Li , Vuong Tri D , Song Qijian , Zhao Lijuan , Shannon J Grover , Li Yan , Nguyen Henry T 
Published: April 2021

Abstract
Aluminium (Al) toxicity inhibits soybean root growth, leading to insufficient water and nutrient uptake. Two soybean lines (‘Magellan’ and PI 567731) were identified differing in Al tolerance, as determined by primary root length ratio, total root length ratio, and root tip number ratio under Al stress. Serious root necrosis was observed in PI 567731, but not in Magellan under Al stress. An F8 recombinant inbred line population derived from a cross between Magellan and PI 567731 was used to map the quantitative trait loci (QTL) for Al tolerance. Three QTL on chromosomes 3, 13, and 20, with tolerant alleles from Magellan, were identified. qAl_Gm13 and qAl_Gm20 explained large phenotypic variations (13–27%) and helped maintain root elongation and initiation under Al stress. In addition, qAl_Gm13 and qAl_Gm20 were confirmed in near-isogenic backgrounds and were identified to epistatically regulate Al tolerance via internal detoxification instead of Al3+ exclusion. Phylogenetic and pedigree analysis identified the tolerant alleles of both loci derived from the US ancestral line, A.K.[FC30761], originally from China. Our results provide novel genetic resources for breeding Al-tolerant soybean and suggest that internal detoxification contributes to soybean tolerance to excessive soil Al.
Structural dynamics and determinants of abscisic acid–receptor binding preference in different aggregation states
Authors: Yang Jing-Fang , Chen Mo-Xian , Zhang Jianhua , Hao Ge-Fei , Yang Guang-Fu 
Published: April 2021

AbstractIn the 21st century, drought has been the main cause of shortages in world grain production and has created problems with food security. Abscisic acid (ABA) is a key plant hormone involved in the response to abiotic stress, especially drought. The pyrabactin resistance (PYR)/PYR1-like (PYL)/regulatory component of abscisic acid receptor (RCAR) family of proteins (simplified as PYLs) is a well-known ABA receptor family, which can be divided into dimeric and monomeric forms. PYLs can recognize ABA and activate downstream plant drought-resistance signals. However, the difference between monomeric and dimeric receptors in the mechanism of the response to ABA is unclear. Here, we reveal that monomeric receptors have a competitive advantage over dimeric receptors for binding to ABA, driven by the energy penalty resulting from dimer dissociation. ABA also plays different roles with the monomer and the dimer: in the monomer, it acts as a ‘conformational stabilizer’ for stabilizing the closed gate, whereas for the dimer, it serves as an ‘allosteric promoter’ for promoting gate closure, which leads to dissociation of the two subunits. This work illustrates how receptor oligomerization could modulate hormonal responses and provides a new concept for novel engineered plants based on ABA binding of monomers.
An upper observable black hole mass scale for tidal destruction events with thermal X-ray spectra
Authors: Mummery Andrew , Balbus Steven A 
Published: April 2021

ABSTRACT
We comprehensively model the X-ray luminosity emergent from time-dependent relativistic accretion discs, developing analytical models of the X-ray luminosity of thermal disc systems as a function of black hole mass M, disc mass Md, and disc α-parameter. The X-ray properties of these solutions will be directly relevant for understanding tidal disruption event (TDE) observations. We demonstrate an extremely strong suppression of thermal X-ray luminosity from large mass black holes, LX ∼ exp (− m7/6), where m is a dimensionless mass, roughly the black hole mass in unity of 106M⊙. This strong suppression results in upper observable black hole mass limits, which we demonstrate to be of order Mlim ≃ 3 × 107M⊙, above which thermal X-ray emission will not be observable. This upper observable black hole mass limit is a function of the remaining disc parameters, and the full dependence can be described analytically (equation 82). We demonstrate that the current population of observed X-ray TDEs is indeed consistent with an upper black hole mass limit of order M ∼ 107M⊙, consistent with our analysis.
Forecasting solar cycle 25 using comprehensive precursor combination and multiple regression technique
Authors: Xiong Yating , Lu Jianyong , Zhao Kai , Sun Meng , Gao Yang 
Published: April 2021

ABSTRACT
In this paper, we propose a new model to predict the complete sunspot cycle based on the comprehensive precursor information (peak, skewness, maximum geomagnetic index aa of the previous cycle, and start value of predicted cycle). The monthly average sunspot original data are processed by Gaussian smoothing and the new model is validated by the observed sunspots of cycle 24. Compared with the traditional 13-month moving average, the Gaussian filter has less missing information and is better to describe the overall trend of the raw data. Through the permutation and combination of multiple parameters in precursor methods of solar cycle forecasting, the multiple regression technique is used to successfully achieve the peak prediction. The regression coefficient (R) of the empirical model established in this paper can reach 0.95. By adding a new parameter to the original HWR function, we provide a complete solar cycle profile showing unimodal structure. It shows that the peak value of cycle 25 will come in March 2024, with a peak of 140.2.
Characterization of 92 southern TESS candidate planet hosts and a new photometric [Fe/H] relation for cool dwarfs
Authors: Rains Adam D , Žerjal Maruša , Ireland Michael J , Nordlander Thomas , Bessell Michael S , Casagrande Luca , Onken Christopher A , Joyce Meridith , Kammerer Jens , Abbot Harrison 
Published: April 2021

ABSTRACT
We present the results of a medium-resolution optical spectroscopic survey of 92 cool ($3000 \,\mathrm{ K}\lesssim T_{\rm eff} \lesssim 4500\,$K) southern TESS candidate planet hosts, and describe our spectral fitting methodology used to recover stellar parameters. We quantify model deficiencies at predicting optical fluxes, and while our technique works well for Teff, further improvements are needed for [Fe/H]. To this end, we developed an updated photometric [Fe/H] calibration for isolated main-sequence stars built upon a calibration sample of 69 cool dwarfs in binary systems, precise to $\pm 0.19\,$dex, from supersolar to metal poor, over 1.51 &lt; Gaia (BP − RP) &lt; 3.3. Our fitted Teff and R⋆ have median precisions of 0.8 per cent and 1.7 per cent, respectively, and are consistent with our sample of standard stars. We use these to model the transit light curves and determine exoplanet radii for 100 candidate planets to 3.5 per cent precision and see evidence that the planet radius gap is also present for cool dwarfs. Our results are consistent with the sample of confirmed TESS planets, with this survey representing one of the largest uniform analyses of cool TESS candidate planet hosts to date.
Hard X-ray emission from a Compton scattering corona in large black hole mass tidal disruption events
Authors: Mummery Andrew , Balbus Steven A 
Published: April 2021

ABSTRACT
We extend the relativistic time-dependent thin-disc TDE model to describe non-thermal (2−10 keV) X-ray emission produced by the Compton up-scattering of thermal disc photons by a compact electron corona, developing analytical and numerical models of the evolving non-thermal X-ray light curves. In the simplest cases, these X-ray light curves follow power-law profiles in time. We suggest that TDE discs act in many respects as scaled-up versions of XRB discs, and that such discs should undergo state transitions into harder accretion states. XRB state transitions typically occur when the disc luminosity becomes roughly one per cent of its Eddington value. We show that if the same is true for TDE discs then this, in turn, implies that TDEs with non-thermal X-ray spectra should come preferentially from large-mass black holes. The characteristic hard-state transition mass is MHS ≃ 2 × 107M⊙. Hence, subpopulations of thermal and non-thermal X-ray TDEs should come from systematically different black hole masses. We demonstrate that the known populations of thermal and non-thermal X-ray TDEs do indeed come from different distributions of black hole masses. The null-hypothesis of identical black hole mass distributions is rejected by a two-sample Anderson-Darling test with a p-value &lt;0.01. Finally, we present a model for the X-ray rebrightening of TDEs at late times as they transition into the hard state. These models of evolving TDE light curves are the first to join both thermal and non-thermal X-ray components in a unified scenario.
Globally visible singularity in an astrophysical setup
Authors: Mosani Karim , Dey Dipanjan , Joshi Pankaj S 
Published: April 2021

ABSTRACT
The global visibility of a singularity as an end state of the gravitational collapse of a spherically symmetric pressureless cloud is investigated. We show the existence of a non-zero measured set of parameters: the total mass and the initial mean density of the collapsing cloud, giving rise to a physically strong globally visible singularity as the end state for a fixed velocity function. The existence of such a set indicates that such singularity is stable under small perturbation in the initial data causing its existence. This is true for marginally as well as non-marginally bound cases. The possibility of the presence of such suitable parameters in the astrophysical setup is then studied: (1) The singularities’ requirements at the centre of the M87 galaxy and at the centre of our galaxy (SgrA*) to be globally visible are discussed in terms of the initial size of the collapsing cloud forming them, presuming that such singularities are formed due to gravitational collapse. (2) The requirement for the primordial singularities formed due to a collapsing configuration after getting detached from the background universe at the time of matter-dominated era just after the time of matter-radiation equality, to be globally visible, is discussed. (3) The scenario of the collapse of a neutron star after reaching a critical mass, which is achieved by accreting the supernova ejecta expelled by its binary companion core progenitor, is considered. The primary aim of this paper is to show that globally visible singularities can form in astrophysical setups under appropriate circumstances.
Oocyte-secreted factors strongly stimulate sFRP4 expression in human cumulus cells
Authors: Esfandyari Sahar , Winston Nicola J , Fierro Michelle A , Scoccia Humberto , Stocco Carlos 
Published: April 2021

Abstract
Secreted frizzled-related protein-4 (SFRP4) belongs to a family of soluble ovarian-expressed proteins that participate in female reproduction, particularly in rodents. In humans, SFRP4 is highly expressed in cumulus cells (CCs). However, the mechanisms that stimulate SFRP4 in CCs have not been examined. We hypothesise that oocyte-secreted factors such as growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are involved in the regulation of SFRP4. Human CCs were collected from patients undergoing fertility treatments and treated with GDF9 or BMP15 or their combination in the presence of FSH or vehicle. FSH treatment significantly decreased SFRP4 mRNA levels when compared with nontreated cells. However, SFRP4 mRNA levels were increased significantly by GDF9 plus BMP15 in a concentration-dependent manner in the presence or absence of FSH. The combination of GDF9 plus BMP15 also increased SFRP4 protein levels and decreased the activity of the β-catenin/T cell factor-responsive promoter significantly. GDF9 plus BMP15 inhibited steroidogenic acute regulatory protein and LH/hCG receptor stimulation by FSH, while treatment with SFRP4 blocked the stimulatory effect of FSH on these genes. The evidence demonstrates that GDF9 and BMP15 act in coordination to stimulate SFRP4 expression and suggests that SFRP4 mediates the anti-luteinising effects of the oocyte in human CCs.
Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing
Authors: Asada Ken , Sakaue Fumika , Nagata Tetsuya , Zhang Ji-chun , Yoshida-Tanaka Kie , Abe Aya , Nawa Makiko , Nishina Kazutaka , Yokota Takanori 
Published: April 2021

Abstract
Antisense oligonucleotide (ASO)-based therapy is one of the next-generation therapy, especially targeting neurological disorders. Many cases of ASO-dependent gene expression suppression have been reported. Recently, we developed a tocopherol conjugated DNA/RNA heteroduplex oligonucleotide (Toc-HDO) as a new type of drug. Toc-HDO is more potent, stable, and efficiently taken up by the target tissues compared to the parental ASO. However, the detailed mechanisms of Toc-HDO, including its binding proteins, are unknown. Here, we developed native gel shift assays with fluorescence-labeled nucleic acids samples extracted from mice livers. These assays revealed two Toc-HDO binding proteins, annexin A5 (ANXA5) and carbonic anhydrase 8 (CA8). Later, we identified two more proteins, apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) and flap structure-specific endonuclease 1 (FEN1) by data mining. shRNA knockdown studies demonstrated that all four proteins regulated Toc-HDO activity in Hepa1–6, mouse hepatocellular cells. In vitro binding assays and fluorescence polarization assays with purified recombinant proteins characterized the identified proteins and pull-down assays with cell lysates demonstrated the protein binding to the Toc-HDO and ASO in a biological environment. Taken together, our findings provide a brand new molecular biological insight as well as future directions for HDO-based disease therapy.
DeepRefiner: high-accuracy protein structure refinement by deep network calibration
Authors: Shuvo Md Hossain , Gulfam Muhammad , Bhattacharya Debswapna 
Published: April 2021

Abstract
The DeepRefiner webserver, freely available at http://watson.cse.eng.auburn.edu/DeepRefiner/, is an interactive and fully configurable online system for high-accuracy protein structure refinement. Fuelled by deep learning, DeepRefiner offers the ability to leverage cutting-edge deep neural network architectures which can be calibrated for on-demand selection of adventurous or conservative refinement modes targeted at degree or consistency of refinement. The method has been extensively tested in the Critical Assessment of Techniques for Protein Structure Prediction (CASP) experiments under the group name ‘Bhattacharya-Server’ and was officially ranked as the No. 2 refinement server in CASP13 (second only to ‘Seok-server’ and outperforming all other refinement servers) and No. 2 refinement server in CASP14 (second only to ‘FEIG-S’ and outperforming all other refinement servers including ‘Seok-server’). The DeepRefiner web interface offers a number of convenient features, including (i) fully customizable refinement job submission and validation; (ii) automated job status update, tracking, and notifications; (ii) interactive and interpretable web-based results retrieval with quantitative and visual analysis and (iv) extensive help information on job submission and results interpretation via web-based tutorial and help tooltips.
Treatment of embryonal tumors with multilayered rosettes with carboplatin/etoposide induction and high-dose chemotherapy within the prospective P-HIT trial
Authors: Juhnke B-Ole , Gessi Marco , Gerber Nicolas U , Friedrich Carsten , Mynarek Martin , von Bueren André O , Haberler Christine , Schüller Ulrich , Kortmann Rolf-Dieter , Timmermann Beate , Bison Brigitte , Warmuth-Metz Monika , Kwiecien Robert , Pfister Stefan M , Spix Claudia , Pietsch Torsten , Kool Marcel , Rutkowski Stefan , von Hoff Katja 
Published: April 2021

Abstract

Background
Embryonal tumors with multilayered rosettes (ETMR) are highly aggressive tumors occurring in early childhood. Published clinical data refer to retrospective, heterogeneously treated cohorts. Here, we describe the outcome of patients treated according to the prospective P-HIT trial and subsequent HIT2000-interim-registry.

Patients and methods
Age-stratified treatment included carboplatin/etoposide induction, tandem high-dose chemotherapy (“CARBO/ETO + HDCT”), and response-stratified radiotherapy. Patients with centrally reviewed neuropathological and molecularly confirmed diagnosis of ETMR recruited within the P-HIT trial (2001-2011; n = 19), the HIT2000-interim-registry (2012-2014; n = 12), and earlier HIT trials (n = 4) were selected for analysis.

Results
Age-adjusted incidence rate was 1.35 per 1 million children (aged 1-4 years) in the years 2012-2014. Median age at diagnosis for 35 patients was 2.9 years. Metastases at diagnosis were detected in 9 patients. One patient died due to postoperative complications. For 30 patients with non-brainstem tumor location, 5-year progression-free survival (PFS) and overall survival (OS) were 35% and 47% after treatment with CARBO/ETO + HDCT (n = 17), compared to 0% and 8% with other treatments (n = 13, P[OS] = .011). All 4 patients with brainstem tumor died within 10 months after diagnosis. By multivariable analysis, supratentorial location: (HR [PFS]: 0.07 [95%CI: 0.01-0.38], P = .003), localized disease (M0): (HR [OS] M0, no residual tumor: 0.30 [95%CI: 0.009-1.09], P = .068; M0, residual tumor: 0.18 [95%CI: 0.04-0.76], P = .020), and CARBO/ETO + HDCT treatment (HR [OS]: 0.16 [95%CI: 0.05-054], P = .003) were identified as independent prognostic factors. Of 9 survivors, 6 were treated with radiotherapy (craniospinal 4; local 2).

Conclusions
Our data indicate improved survival with intensified chemotherapy (CARBO/ETO + HDCT). However, despite intensive treatment, the outcome was poor. Thus, innovative therapies need to be evaluated urgently in an upfront setting.