bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Localized Waves and their Interaction Solutions for a Dimensionally Reduced (2+1)-dimensional Boussinesq Equation from N-soliton Solutions
Authors: Kumar Dipankar , Nuruzzaman Md. , Paul Gour Chandra , Hoque Ashabul 
Published: July 2021

Abstract
The Boussinesq equation (BqE) has been of considerable interest in coastal and ocean engineering models for simulating surface water waves in shallow seas and harbors, tsunami wave propagation, wave over-topping, inundation, and near-shore wave process in which nonlinearity and dispersion effects are taken into consideration. The study deals with the dynamics of localized waves and their interaction solutions to a dimensionally reduced (2 + 1)-dimensional BqE from N-soliton solutions with the use of Hirota’s bilinear method (HBM). Taking the long-wave limit approach in coordination with some constraint parameters in the N-soliton solutions, the localized waves (i.e., soliton, breather, lump, and rogue waves) and their interaction solutions are constructed. The interaction solutions can be obtained among localized waves, such as (i) one breather or one lump from the two solitons, (ii) one stripe and one breather, and one stripe and one lump from the three solitons, and (iii) two stripes and one breather, one lump and one periodic breather, two stripes and one lump, two breathers, and two lumps from the four solitons. It is to be found that all interactions among the solitons are elastic. The energy, phase shift, shape, and propagation direction of these localized waves and their interaction solutions can be influenced and controlled by the involved constraint parameters. The dynamical characteristics of these localized waves and their interaction solutions are demonstrated through some 3D and density graphs. The outcomes achieved in this study can be used to illustrate the wave interaction phenomena in shallow water.
Bacteroidota and Lachnospiraceae Integration Into the Gut Microbiome at Key Time Points in Early Life are Critical for Neurodevelopment
Authors: Oliphant Kaitlyn , Ali Mehneez , D'Souza Mark , Hughes Patrick D. , Sulakhe Dinanath , Wang Annie Z. , Xie Bingqing , Yeasin Rummanu , Msall Michael M. , Andrews Bree , Claud Erika C. 
Published: July 2021

Abstract
Background: The early life microbiome plays critical roles in host development, shaping long-term outcomes including brain functioning. It is not known which initial infant colonizers elicit optimal neurodevelopment; thus, this study investigated the association between gut microbiome succession from the first week of life and head circumference growth (HCG), the earliest validated marker for neurodevelopment. Faecal samples were collected weekly from a preterm infant cohort during their neonatal intensive care unit stay and subjected to 16S rRNA gene sequencing for evaluating gut microbiome composition, in conjunction with clinical data and head circumference measurements. Results: Preterm infants with suboptimal HCG trajectories had a depletion in the abundance/prevalence of Bacteroidota and Lachnospiraceae, independent of morbidity and caloric restriction. The severity of gut microbiome depletion matched the timing of significant HCG pattern separation between study groups at 30 weeks postmenstrual age. Consideration of the clinical variables indicated that optimal infant microbiome succession is primarily driven by dispersal limitation (i.e., delivery mode) and secondarily by habitat filtering (i.e., antibiotics and enteral feeding). Conclusions: Bacteroidota and Lachnospiraceae are known core taxa of the adult microbiome, with roles in dietary glycan foraging, beneficial metabolite production and immunity, and our work provides strong evidence that their integration into the gut microbiome needs to occur early for optimal neurodevelopment.
Impact of Treatment on Cessation of Air Leakage and Recurrence of Spontaneous Pneumothorax: A Case Control Study
Authors: Nakano Takahito , Kaneda Hiroyuki , Fukumoto Kento , Matsui Hiroshi , Taniguchi Yohei , Saito Tomohito , Murakawa Tomohiro 
Published: July 2021

Abstract
Background: Conservative observation with/without oxygen supplementation, aspiration, or tube drainage is selected as an initial treatment for spontaneous pneumothorax. In this study, we have examined the efficacy of initial management for cessation of air leak and prevention of recurrence separately, with consideration of the degree of lung collapse.Methods: Spontaneous pneumothorax in patients who underwent initial management in our institute between January 2006 and December 2015 were included in this retrospective, single-institutional study. Multivariate analyses were conducted to identify risk factors related to the persistent air leak after initial treatment and those related to ipsilateral recurrence after last treatment.Results: In the multivariate analysis for predicting persistent air leak after first treatment, repeated episode of ipsilateral pneumothorax (p = 0.0022), high degree of lung collapse (p = 0.032), and bulla formation (p < 0.0001) were the statistically significant risk factors for treatment failure. Recurrence of ipsilateral pneumothorax was observed in 126 cases. In the multivariate analysis for predicting the recurrence, repeated episode of ipsilateral pneumothorax was the significant risk factor (p = 0.0032).Conclusions: Predicting factors for persistent air leak after initial treatment were recurrence of ipsilateral pneumothorax, high degree of lung collapse, and radiological evidence of bullae. The predictive factor for recurrence after the last treatment was recurrence of ipsilateral pneumothorax. Selection of either observational or interventional approach at initial management did not affect the outcomes evaluated. Therefore, because of treatment invasiveness, observation is recommended to be attempted first in cases sans risk factors.Trial Registration: retrospectively registeredDate of IRB approval: May 28, 2018Number of IRB approval: 2017320
ADRC-Backstepping-Compensation Control for A Novel Aerial Manipulator System
Authors: Ma Le , YAN Yiming , Li Zhiwei , Liu Jie 
Published: July 2021

Abstract
This paper proposes a fully-actuated control method for a novel aerial manipulation system (AMS). A customized carbon frame structure supports the servo actuators, on which eight propellers group into pairs located. We present kinematics and dynamics modeling of the AMS based on Craig parameter method and recursive Newton–Euler equation, respectively. Then, an Active disturbance rejection control (ADRC)–Backstepping–Compensation controller is designed to control the exact position and orientation of the manipulator in the Cartesian space. Finally, the performance of the system is demonstrated through simulations and outdoor experiments.
The Effect of Lipid Accumulation Product and Its Interaction With Family History of Hypertension on Hypertension Risk in Population With Nondiabetic in Eastern China: A Cross-sectional Study
Authors: Shu Li , Song Lina , Shen Yanqi , Wang Jinchen , Han Ziyan , Shu Li 
Published: July 2021

Abstract
Background: Lipid Accumulation Product (LAP) was proposed as a useful indicator of visceral obesity, the visceral obesity and cardiovascular diseases are closely related. However, the empirical evidences of LAP and hypertension (HTN) are limited. Our study sought to assess the risk factors of HTN and prehypertension (PHT), and provide an insight into the possible interacting influences of LAP with family history of HTN on the risk of HTN in the nondiabetic Eastern Chinese population. Methods: A large cross-sectional study was conducted in community health service centers in urban Bengbu of Anhui province, China. All elderly person aged 45 years and older were performed an interview questionnaire, physical measurements and biochemical indicators examinations by trained staffs. Common indexes to screen obese persons such as body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and LAP were calculated. Multivariate logistic regression was used to test the prevalence of HTN and PHT in relation to each quartile increase in LAP level and family history of HTN. The receiver operating characteristic (ROC) analysis was applied to calculate the best cut-off value of LAP and identify the superior obesity indicator. The interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI). Results: 7733 subjects were enrolled in our study, the overall prevalence rates of normotension, PHT and HTN were 38.1%, 37.1% and 24.8%, respectively. The prevalence of HTN increased rapidly across LAP quartiles in males and females, the LAP values in the top quartile were significantly higher than those in the bottom quartile (31.8% vs. 17.6% in males, p for trend <0.001; 31.4% vs. 18.8% in females, p for trend <0.001). The AUC value of LAP were superior to BMI in males (Z=6.627, p<0.001) and females (Z=8.045, p<0.001). Multinomial logistic regression analysis showed that compared with subjects in LAP quartile 1, those in quartile 3 (OR: 1.612, 95% CI: 1.386-1.876) and quartile 4 (OR: 1.942, 95% CI: 1.673-2.253) had significantly higher risk of HTN (p for trend<0.001) after adjusting for confounding factors. A significant interaction was observed between LAP and family history of HTN in males (AP: 0.1663, 95% CI: 0.0027-0.3299; SI: 1.4035, 95% CI: 1.0597-1.8590) and females (RERI: 1.4109, 95% CI: 0.1455-2.9674; AP: 0.1664, 95% CI: 0.0088-0.3240; SI: 1.3884, 95% CI: 1.0565-1.8245). Conclusion: LAP is a simple and convenient index to predict the HTN risk, higher LAP values have relatively associated with higher blood pressure (BP). The results demonstrated that interactive effects of LAP with family history of HTN may synergistically influence the development of HTN.
Biodiversity of Fungi, Causing Wood Biodeterioration In Buildings In Poland Against The Background Of Research Conducted In Other European Countries.
Authors: Andres Bogusław Adam , Krajewski Krzysztof J. , Betlej Izabela 
Published: July 2021

Abstract
The paper presents the results of surveys on the diversity of wood-destroying fungi in buildings and wooden engineering structures outdoors in Poland. The respondents reported a total of 48 species and genus of wood-degrading Basidiomycetes. The greatest species diversity of wood-degrading fungi was found on open-air engineering structures (33 species), the second location in terms of biodiversity was unused residential buildings (30 species), the lowest biodiversity was found in the used residential buildings (21 species).The most common fungi in the buildings were Serpula lacrymans (24.8%), Coniophora puteana (14.1%) and Fibroporia vaillantii (13.8%). The prevalence of S. lacrymans and C. puteana in buildings in Poland is similar to the European average. The occurrence of indoor polypores group (Amyloporia sinuosa, Fibroporia vaillantii, Neoantrodia serialis) in Poland is twice as high as the European average. Donkioporia expansa, which is numerous in buildings in Western Europe, is sporadically recorded in Poland (0.1%).
Widespread reductions in human labor capacity after 1.5°C warming
Authors: Yan Karena , Schlunegger Sarah , MacGilchrist Graeme , Rodgers Keith , Stein Karl , Dunne John , Slater Richard , Lee Sun-Seon , Rosenbloom Nan , Edwards James 
Published: July 2021

Abstract
Rising temperatures and specific humidity are compounding influences that increase heat stress and reduce safe labor capacity. Here, we evaluate reductions in summertime labor capacity using Large Ensemble experiments from two Earth System Models (ESMs). Vulnerable regions, including the Indian subcontinent, Southeast Asia, and West Africa, are expected to begin experiencing 25% reductions as early as the 2040s. Internal climate variability can cloud the timing of such reductions, with differences in onset between ensemble members exceeding 40 years in high-variability locations. At regional scales, onset times are more certain, with differences between ensemble members typically less than 20 years. We demonstrate the benefits for maintaining human labor capacity associated with limiting the increase in global mean surface temperature (ΔGMST) to 1.5°C, consistent with the Paris Agreement. If ΔGMST exceeds 3.5°C, at least 15% of the global population is projected to experience 50% reductions in summertime labor capacity.
Factors Related to Turnover Intention Among Staff of Elderly Caring Social Organizations in Anhui Province, China: A Cross-sectional Study
Authors: Chen Xuefei , Tang Ling , liu Liu , Bai Zhongliang , Chen Ren 
Published: July 2021

Abstract
Objective: Turnover intention of employees in elderly caring social organizations has a significant impact on elderly care service delivery. This study investigated the associated factors of turnover intention among employees of elderly caring social organizations in Anhui Province, China.Methods: A total of 605 participants were selected using a multi-stage stratified random sampling method. A self-administered questionnaire was used to collect information on socio-demographic, social support, and turnover intention from the participants. The data was analyzed through descriptive statistical analysis, one-way variance analysis, Spearman correlation analysis, and multiple linear regression. Results: Results of our study showed that the total score of turnover intention, turnover intention I, turnover intention II and turnover intention III were 8.84, 2.32, 2.38, and 4.14, respectively. Social support negatively correlated with turnover intention I and turnover intention II. However, it showed positive correlation with turnover intention III and total turnover intention scores; turnover intentionⅠ(coefficient: -0.082), turnover intention Ⅱ(coefficient: -0.071), turnover intention Ⅲ(coefficient: 0.19), Total score of turnover intention (coefficient: 0.093). Ethnic group, age, education level, and job satisfaction were associated with turnover intention.Conclusion :Improvement of social support play an important role in reducing the turnover intention of employees in elderly caring social organizations. It is important to increase organizational commitment and strengthen psychological empowerment, combined with decreasing job burnout for stability.
Effect of Sodium Silicate and Salicylic Acid on Sodium and Potassium Ratio in Wheat (Triticum aestivum L.) Grown Under Salt Stress
Authors: Mushtaq Ayesha , Sabir Nazish , Kousar Tasneem , Rizwan Sabeena , Jabeen Uzma , Bashir Farrukh , Sabir Sadia , Shahwani Naeem 
Published: July 2021

Abstract
Purpose Salinity pose severe threat to cultivation as it drastically affects the plant sustainability and yield. The intended aim of current consensus is to assess effects of sodium silicate and salicylic acid on wheat genotypes (slat tolerant and salt sensitive) grown under salt. Methods This experiment was designed to check the effect of silicon on wheat varieties, so four different wheat genotypes named as (Umeed, Rasco, Zarghoon and Shahkaar) were grown in hydroponics under saline and normal environment. Sodium silicate and salicylic acid were applied on all varieties to determine the slat tolerance ability. Plants were harvested at maturity and different physical and chemical aspects were recorded. Results To assess the salt stress on growth and yield of wheat genotypes. Wheat grown in saline conditions with sodium silicate supplementation showed improvement in all growth parameters as compared to the plants grown under salt stress without silicon supplementation. Higher contents of potassium were observed in plants grown under salt stress with silicon supplementation however, potassium concentration was found less in salicylic acid treatment and control under salt stress. Sodium concentration was found higher under salt stress but sodium silicate application reduced Na+ uptake under salt stress. Significance increase in K+ : Na+ ratio in roots enhance the translocation which in turn elevates salt tolerance ability. Among wheat varieties potassium uptake was quite high in Umeed and Rasco as compared to Zarghoon and Shahkar. Conclusion Based on current results it can be deduced that application of sodium silicate on different wheat varieties mitigated Na+ toxicity by elevating K+: Na+ ratio and net translocation rate in salt stressed plants.
Mapping of Population Disparities in the Cholangiocarcinoma Urinary Metabolome
Authors: Alsaleh Munirah , Leftley Zoe , Connor Thomas O’ , Hughes Thomas , Barbera Thomas A. , Koomson Larry K. , Zabron Abigail , Reeves Helen , Cramp Matthew , Ryder Stephen D , Greer Shaun , Prince Martin , Sithithaworn Paiboon , Khuntikeo Narong , Loilome Watcharin , Yongvanit Puangrat , Cox I Jane , Williams Roger , Wadsworth Christopher A. , Holmes Elaine , Nash Kathryn , Andrews Ross , Taylor-Robinson Simon D 
Published: July 2021

Abstract
Background Phenotypic diversity in urinary metabolomes of different geographical populations has been recognized recently. In this study, urinary metabolic signatures from Western (United Kingdom) and South-East Asian (Thai) cholangiocarcinoma patients were characterized to understand spectral variability due to host carcinogenic processes and/or exogenous differences (nutritional, environmental and pharmaceutical). Methods Urinary liquid chromatography mass spectroscopy (LC-MS) spectral profiles from Thai (healthy=20 and cholangiocarcinoma=14) and UK cohorts (healthy=22 and cholangiocarcinoma=10) were obtained and modelled using chemometric data analysis. Results Healthy metabolome disparities between the two distinct populations were primarily related to differences in dietary practices and body composition. Metabolites excreted due to drug treatment were dominant in urine specimens from cholangiocarcinoma patients, particularly in Western individuals. Urine from participants with sporadic (UK) cholangiocarcinoma contained greater levels of a nucleotide metabolite (uridine/pseudouridine). Higher relative concentrations of 7-methylguanine were observed in urine specimens from Thai cholangiocarcinoma patients. The urinary excretion of hippurate and methyladenine (gut microbial-host co-metabolites) showed a similar pattern of lower levels in patients with malignant biliary tumours from both countries.Conclusion Intrinsic (body weight and body composition) and extrinsic (xenobiotic metabolism) factors were the main causes of disparities between the two populations. Regardless of the underlying aetiology, biological perturbations associated with cholangiocarcinoma urine metabolome signatures appeared to be influenced by gut microbial community metabolism. Dysregulation in nucleotide metabolism was associated with sporadic cholangiocarcinoma, possibly indicating differences in mitochondrial energy production pathways between cholangiocarcinoma tumour subtypes. Mapping population-specific metabolic disparities may aid in interpretation of disease processes and identification of candidate biomarkers.
Design &amp; Development of Laser Etched Porous-Silicon Capacitive Chip for Rapid Sensing of Pesticide Solvents
Authors: Gheewala Shailesh Mahendralal , Parmesh Chinthakunta , Patel Piyush N. , Dhavse Rasika 
Published: July 2021

Abstract
This work presents the development of porous silicon-based electrical sensor for the detection and quantification of organic solvents. The design of silicon chip is modeled as capacitive sensor. Different electrode configurations like coplanar top electrodes, top-bottom, coplanar bottom electrodes were analyzed in order to select optimum chip design for sensing application. The prototype chip was fabrication that used a mechanized pulse fiber laser etching process in order to develop a single-layer silicon structure with uniform porous structures. The fabricated chip was characterized using scanning electron microscopy and it shows an average pore diameter of 55.22 µm and pore depth of 98.9 µm. Organic solvents like ethanol, methanol, acetonitrile were tested and analyzed in order to investigate the performance of the proposed chip. Unlike porous silicon based optical sensors, the proposed sensor exhibited stable results up to 35 days at room temperature. The application of the proposed sensor chip is demonstrated for sensing and for the quantification of Atrazine chemical which is a pesticide solvent which is utilized in farming to control weeds. The sensitivity and the limit of detection was found to be 0.51 nF/ppm and 0.929 ppm respectively. The proposed capacitive-based porous silicon chip is suitable for time-effective and low-cost sensing and detection of organic solvents that are used in food industry.
Bioinformatic Analysis Identifying S100a9 Associated With Cell Proliferation and Metastasis in Neuroblastoma
Authors: Chen Xian , Xue Yukun , Feng Jiao , Tian Qingwu , Zhang Yunyuan , Wang Qing 
Published: July 2021

Abstract
Background: More than half of neuroblastoma (NB) patients presented with distant metastases and the mortality of patients suffering from metastatic relapse was about 90%. It is urgent to find a biomarker that can facilitate the prediction of metastasis in NB patients. Methods and Results: In the present study, we systematically analyzed Gene Expression Omnibus (GEO) datasets and focused on identifying the critical molecular networks and novel key hub genes implicated in NB. We found totally, 176 up-regulated and 19 down-regulated differentially expressed genes (DEGs) were identified. Based on these DEGs, a PPI network composed of 150 nodes and 452 interactions was established. PPI network identification combined with qRT-PCR, ELISA and IHC, S100A9 as was screened as an outstanding gene. Furthermore, in vitro tumorigenesis assays demonstrated that S100A9 overexpression enhanced the proliferation, migration, and invasion of NB cells. Conclusions: Taken together, our findings suggested that S100A9 could participate in NB tumorigenesis and metastasis and that S100A9 has the potential to be used as a biomarker in the prediction of NB metastasis.
Residual Symptoms, Lung Function and Imaging Findings in Patients Recovering from SARS-CoV-2 Infection
Authors: darawshy fares , Rmeileh Ayman Abu , Kuint Rottem , Padawer Dan , Karim Khalil , Fridlender Zvi G , Laxer Uri , Goychman Polina Cohen , Berkman Neville 
Published: July 2021

Abstract
RationaleSymptoms following acute COVID-19 infection are common, but their relationship to initial COVID-19 severity is unclear. We hypothesize that residual symptoms are related to disease severity, and severe acute COVID-19 infection is more likely to cause residual pulmonary damage. This study aims to evaluate symptoms, lung function and abnormal imaging within 3 months following COVID-19 infection, and whether they are related to initial disease severity.Methods A cross-sectional study was carried out at a designated post-COVID clinic in Hadassah Medical Center, Jerusalem, Israel. Patients with PCR-confirmed SARS-CoV-2 infection were evaluated within 12 weeks following infection and included both admitted and non-admitted subjects. All participants underwent assessment of symptoms, quality of life (SGRQ), pulmonary function tests, and imaging. Results A total of 208 patients (age 49.3±16 years) were included in the study. Initial disease severity was mild in 86, moderate in 49 and severe in 73 patients. At the time of follow up, there were no differences in frequency of residual symptoms or in SGRQ score between groups. Patients with severe COVID-19 were more likely to have residual dyspnea (p=0.04), lower oxygen saturation (p<0.01), lower FVC and TLC (p<0.001, p=0.03 respectively), abnormal CXR (p<0.01) and abnormal CT scan (p<0.01) compared to other groups. Conclusion Frequency of symptoms and impairment of quality of life at 12 weeks follow up are common and are not related to severity of initial COVID-19 disease. In contrast, reduced lung function and abnormal pulmonary imaging are more common in patients with more severe acute COVID-19 infection.