bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are small protected habitat patches within boreal production forests effective in conserving species richness, abundance and community composition? A systematic review
Authors: Häkkilä Matti , Johansson Anna , Sandgren Terhi , Uusitalo Anne , Mönkkönen Mikko , Puttonen Pasi , Savilaakso Sini 
Published: January 2021

Abstract
Background
In boreal zone forest management is changing and degrading forest habitats, which has caused declines in biodiversity. To mitigate these harmful effects in production forests, small-scale habitats with high biodiversity values have been protected within them. These habitats include woodland key habitats, and other small habitat patches protected by voluntary conservation actions. In this systematic review we synthesize the evidence on the value of small protected habitat patches (SPHP) within production forest landscapes for biodiversity. Review question: Are small protected habitat patches within boreal production forests effective in conserving species richness, abundance, and community composition?

Methods
Both peer-reviewed and grey literature were searched from bibliographical databases, organizational websites and internet search engines in English, Finnish, Swedish and Russian. Articles were screened at two stages (title/abstract and full text) and the validity of the included studies were assessed. Screening and validity assessment were based on predetermined criteria. After data extraction, narrative and quantitative syntheses were conducted. Influences of effect modifiers were tested, and sensitivity analyses were conducted.

Review findings
During the searches 19,458 articles were found. After duplicate removal and title/abstract screening 336 articles remained. During full text screening 41 articles were included and 35 of them (174 studies) were included in narrative synthesis. 28 articles with 127 studies had suitable data for meta-analysis. SPHPs had significantly higher species richness compared to production forests. When compared to natural forests, there was no significant difference. Forest management in areas surrounding SPHPs did not have impact on species richness of these patches. Individual abundance was significantly higher in SPHPs compared to natural or production forests. There was significantly more dead wood in SPHPs compared to production forests, but when compared to natural forests there was no significant difference. Community composition was different between SPHPs and both production and natural forests.

Conclusions
The findings of this review show that small protected patches within production forests are important part of biodiversity conservation. They cannot substitute larger protected areas but supplement the protected area network. However, there were gaps both in geographical distribution of the studies as well as in the selection of target species of the studies. Therefore, generalization of the results must be done carefully.
Compliance with antibiotic prophylaxis guidelines in caesarean delivery: a retrospective, drug utilization study (indication-prescription type) at an Ecuadorian hospital
Authors: Romero Viamonte Katherine , Salvent Tames Adrian , Sepúlveda Correa Rosa , Rojo Manteca María Victoria , Martín-Suárez Ana 
Published: January 2021

Abstract
Background
Preoperative antibiotic prophylaxis is essential for preventing surgical site infection (SSI). The aim of this study was to evaluate compliance with international and local recommendations in caesarean deliveries carried out at the Obstetrics and Gynaecology Service of the Ambato General Hospital, as well as any related health and economic consequences.

Methods
A retrospective indication-prescription drug utilization study was conducted using data from caesarean deliveries occurred in 2018. A clinical pharmacist assessed guidelines compliance based on the following criteria: administration of antibiotic prophylaxis, antibiotic selection, dose, time of administration and duration. The relationship between the frequency of SSI and other variables, including guideline compliance, was analysed. The cost associated with the antibiotic used was compared with the theoretical cost considering total compliance with recommendations. Descriptive statistics, Odds Ratio and Pearson Chi Square were used for data analysis by IBM SPSS Statistics version 25.

Results
The study included 814 patients with an average age of 30.87 ± 5.50 years old. Among the caesarean sections, 68.67% were emergency interventions; 3.44% lasted longer than four hours and in 0.25% of the deliveries blood loss was greater than 1.5 L. Only 69.90% of patients received preoperative antibiotic prophylaxis; however, 100% received postoperative antibiotic treatment despite disagreement with guideline recommendations (duration: 6.75 ± 1.39 days). The use of antibiotic prophylaxis was more frequent in scheduled than in emergency caesarean sections (OR = 2.79, P = 0.000). Nevertheless, the timing of administration, antibiotic selection and dose were more closely adhered to guideline recommendations. The incidence of surgical site infection was 1.35%, but tended to increase in patients who had not received preoperative antibiotic prophylaxis (OR = 1.33, P = 0.649). Also, a significant relationship was found between SSI and patient age (χ2 = 8.08, P = 0.036). The mean expenditure on antibiotics per patient was 5.7 times greater than that the cost derived from compliance with international recommendations.

Conclusions
Surgical antibiotic prophylaxis compliance was far below guideline recommendations, especially with respect to implementation and duration. This not only poses a risk to patients but leads to unnecessary expenditure on medicines. Therefore, this justifies the need for educational interventions and the implementation of institutional protocols involving pharmacists.
Bacterial but no SARS-CoV-2 contamination after terminal disinfection of tertiary care intensive care units treating COVID-19 patients
Authors:   for the COVID-19 ICU-Research Group Zurich, Hofmaenner Daniel A. , Wendel Garcia Pedro David , Duvnjak Branko , Chakrakodi Bhavya , Maier Julian D. , Huber Michael , Huder Jon , Wolfensberger Aline , Schreiber Peter W. , Schuepbach Reto A. , Zinkernagel Annelies S. , Buehler Philipp K. , Brugger Silvio D. 
Published: January 2021

Abstract
Background
In intensive care units (ICUs) treating patients with Coronavirus disease 2019 (COVID-19) invasive ventilation poses a high risk for aerosol and droplet formation. Surface contamination of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) or bacteria can result in nosocomial transmission.

Methods
Two tertiary care COVID-19 intensive care units treating 53 patients for 870 patient days were sampled after terminal cleaning and preparation for regular use to treat non-COVID-19 patients.

Results
A total of 176 swabs were sampled of defined locations covering both ICUs. No SARS-CoV-2 ribonucleic acid (RNA) was detected. Gram-negative bacterial contamination was mainly linked to sinks and siphons. Skin flora was isolated from most swabbed areas and Enterococcus faecium was detected on two keyboards.

Conclusions
After basic cleaning with standard disinfection measures no remaining SARS-CoV-2 RNA was detected. Bacterial contamination was low and mainly localised in sinks and siphons.
Phenotypic and genomic relationships between vulva score categories and reproductive performance in first-parity sows
Authors: Corredor Flor-Anita , Sanglard Leticia P. , Ross Jason W. , Keating Aileen F. , Leach Richard J. , Serão Nick V. L. 
Published: January 2021

Abstract
Background
One of the biggest challenges in the swine industry is to increase female reproductive efficiency. Recently, vulva score categories (VSC), assessed prior to puberty, has been proposed as an indicator trait of efficient reproductive performance in sows. The objective of this study was to validate the use of VSC as an indicator trait for reproductive performance, and to perform genetic and genomic analyses for VSC.

Methods
The phenotypic relationship of VSC, using a three-point scale: small (VSC-S), medium (VSC-M), and large (VSC-L), on reproductive performance was evaluated on three farms. VSC was measured at 15 weeks of age, for farms 1 and 2, and at 14 weeks of age for farm 3 on 3981 Yorkshire gilts, in which 1083 had genotypes (~ 50 K SNPs). Genetic parameters for VSC with reproductive traits were estimated using ssGBLUP. A Genome-wide association study (GWAS) for VSC was performed using BayesB.

Results
For the phenotypic analysis of VSC across datasets, differences in performance were identified there was a significant effect (P ≤ 0.05) for the interaction between Farm and VSC for total number dead (TND), and a trend (P < 0.10) for total number born (TNB). There were significant (P ≤ 0.05) pre-defined contrasts of VSC-S versus VSC-M + L on TNB, number born alive (NBA), TND, number of stillborn (NSB), and number of mummies (MUM). Heritability estimates for VSC as a categorical trait (VSCc) and a quantitative trait (VSCq) were 0.40 ± 0.02 and 0.83 ± 0.02, respectively, for across farm, 0.13 ± 0.07 and 0.20 ± 0.10, respectively, for Farm1, 0.07 ± 0.07 and 0.09 ± 0.09, respectively, for Farm2, and 0.20 ± 0.03 and 0.34 ± 0.05, respectively, for Farm3. For across farms, favorable genetic correlations estimates were found for TNB (0.28 ± 0.19) and NBA (0.26 ± 0.17). Within farms, moderate genetic correlations between VSC with reproductive traits were found for TNB (0.61 ± 0.47) and MUM (0.69 ± 0.47) for farm 1, for number of services until first farrow (NS; 0.69 ± 0.38) and unique service with successful first farrow (SFS; − 0.71 ± 0.38) for farm 3. Multiple genomic regions associated with VSCc were identified. Of these, a QTL located on chromosome 3 at 33–34 Mb accounted for about 7.1% of the genetic variance for VSCc and VSCq. This region harbors the gene PRM1 that has been associated with early embryonic development in pigs.

Conclusions
The results support potential of VSC for improved reproductive efficiency on first-parity performance, but the results might depend on the interaction between environmental factors and VSC, as well as potentially additive genetics.
A philosophical perspective on the prenatal in utero microbiome debate
Authors: Walter Jens , Hornef Mathias W. 
Published: January 2021

AbstractWithin the last 6 years, a research field has emerged that focuses on the characterization of microbial communities in the prenatal intrauterine environment of humans and their putative role in human health. However, there is considerable controversy around the existence of such microbial populations. The often contentious debate is primarily focused on technical aspects of the research, such as difficulties to assure aseptic sampling and to differentiate legitimate signals in the data from contamination. Although such discussions are clearly important, we feel that the problems with the prenatal microbiome field go deeper. In this commentary, we apply a philosophical framework to evaluate the foundations, experimental approaches, and interpretations used by scientists on both sides of the debate. We argue that the evidence for a “sterile womb” is based on a scientific approach that aligns well with important principles of the philosophy of science as genuine tests of the hypothesis and multiple angles of explanatory considerations were applied. In contrast, research in support of the “in utero colonization hypothesis” is solely based on descriptive verifications that do not provide explanatory insight, which weakens the evidence for a prenatal intrauterine microbiome. We propose that a reflection on philosophical principles can inform not only the debate on the prenatal intrauterine microbiome but also other disciplines that attempt to study low-biomass microbial communities.
Quarantining arriving travelers in the era of COVID-19: balancing the risk and benefits a learning experience from Bahrain
Authors: Abdulrahman Abdulkarim , AlSabbagh Manaf , AlAwadhi Abdulla , Al-Tawfiq Jaffar A. , Rabaan Ali A. , Atkin Stephen , AlQahtani Manaf 
Published: January 2021

AbstractThe quarantine period imposed to travelers in many countries due to COVID19 is a major obstacle for any traveler. Lifting the quarantine period could lead to significant improvement in people’s quality of life and any country’s economy. Bahrain have used two quarantine models from arriving passengers. We report data about the incidence of COVID19 on arriving passengers at Bahrain International airport. Infection rates were reported on arrival, during quarantine and after leaving quarantine. Results showed that travelers had low incidence of COVID19 on arriving and during the quarantine period, while becoming at higher risk after leaving quarantine. We concluded that quarantine requirement maybe lifted for arriving travelers. Testing upon arrival with implementation of the public health preventative measures can minimize the risk of transmission.
Visualization of flow dynamics in the portal circulation using 320-detector-row computed tomography: a feasibility study
Authors: Kageyama Ken , Yamamoto Akira , Jogo Atsushi , Izuta Shinichiro , Himoto Daisuke , Kakimi Akihiko , Sohgawa Etsuji , Miki Yukio 
Published: January 2021

AbstractMultidetector row computed tomography (CT) scanners perform dynamic scanning and have a wide scan range. Time-resolved three-dimensional CT (i.e., 4D CT) has recently enabled visualization of flow in neurovascular vessels. We hypothesized that 4D CT technology would be a useful and non-invasive method for visualizing the flow dynamics of the portal circulation. The aim of this study was to evaluate the technical feasibility of 4D CT for visualizing flow dynamics in the portal circulation using 320-detector-row CT. 4D CT images of 18 consecutive patients with portal circulation including gastrorenal shunt were retrospectively evaluated for their ability to generate flow dynamics of the portal circulation. Flow dynamics could be visualized by 4D CT in 68 of the 72 vessels in the portal vein, splenic vein, superior mesenteric vein, and gastrorenal shunt. Flow direction could not be identified in four vessels, all of them being superior mesenteric veins. Flow direction was recognized on 4D CT in the 68 vessels of the portal circulation. A preliminary validation study revealed that flow direction of all 19 vessels in the portal circulation had concordance between 4D CT and color Doppler ultrasound. 4D CT could visualize flow dynamics of the portal circulation.
The neuropathological impact of COVID-19: a review
Authors: Ibrahim Fouad Ghadha 
Published: January 2021

Abstract
Background
The Coronavirus disease 2019 (COVID-19) outbreak has become a challenging global issue after its emergence in December 2019. Due to the high adaptation of the virus, COVID-19 demonstrated a high transmission and infectivity potentials. Several studies demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induce deleterious neurological manifestations through interacting with the central nervous system (CNS).

Main body
The neuroinvasive potential of SARS-CoV-2 might contribute to its fatal behavior. Understanding the underlying mechanisms of this novel neuropathogen might contribute to the development of effective therapeutic strategies. The manifestations of neural damage in COVID-19 patients ranged from headache to severe encephalopathy and progression of preexisting neural disorders, it is speculated that neuroinvasion is strongly linked to the fatal respiratory dysfunction. The underlying neuropathological impact of emerging pneumonia (COVID-19) is still unclear.

Conclusion
This review demonstrated the urgent need to understand the neuropathology of COVID-19, to manage the current borderless viral outbreak of SARS-CoV-2 and its comorbidities. Moreover, SARS-CoV-2 could be regarded as an opportunistic neuropathogen that affects several vital functions in the human body.
The effects of weather on the spread of COVID-19: evidence from Ghana
Authors: Aidoo Eric N. , Adebanji Atinuke O. , Awashie Gaston E. , Appiah Simon K. 
Published: January 2021

Abstract
Background
Climatic factors have been shown to influence communicable disease dynamics especially in tropical regions where temperature could swing from extreme heat and dryness to wet and cold within a short period of time. This is more pronounced in the spread of airborne diseases. In this study, the effect of some local weather variables (average temperature, average relative humidity, average wind speed and average atmospheric pressure) on the risk of Severe Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Ghana is investigated. The daily confirmed new COVID-19 cases were compiled from the Ghana Health Service and the weather data extracted from Weatherbase. The type of relationship between the climatic variable and risk of spread were explored using the Generalized Additive Model (GAM).

Results
Results obtained showed that wind speed and atmospheric pressure have positive linear relationship with the spread of infection an increase in the risk of COVID-19 spread. In addition, the risk of spread fluctuates for temperature between 24 and 29 °C but sharply decreases when average temperature exceeds 29 °C. The risk of spread of COVID-19 significantly decrease for relative humidity between 72 and 76% and leveled afterwards.

Conclusion
The results indicate that wind speed and pressure have a positive linear relationship with the risk of spread of COVID-19 whilst temperature and humidity have a non-linear relationship with the spread of COVID-19. These findings highlight the need for policy makers to design effective countermeasures for controlling the spread as we are still within the low temperature season.
Exploring the usability of the COM-B model and Theoretical Domains Framework (TDF) to define the helpers of and hindrances to evidence-based practice in midwifery
Authors: De Leo Annemarie , Bayes Sara , Bloxsome Dianne , Butt Janice 
Published: January 2021

Abstract
Background
Despite the advancement of scientific research in the field of maternity care, midwives face challenges translating latest evidence into evidence-based practice (EBP) and express reticence towards leading practice change in clinical areas. This study aimed to explore midwifery leaders’ views on what factors help or hinder midwives’ efforts to translate latest evidence into everyday practice and consider them in relation to both the Capability, Opportunity, Motivation and Behaviour (COM-B) model and Theoretical Domains Framework (TDF).

Methods
This qualitative study formed part of a larger action research (AR) project that was designed to improve midwives’ EBP implementation capability. Data were obtained from eight Western Australian midwifery leaders who were employed in either managerial or executive positions within their organisation. Five midwives attended a focus group workshop and three opted for face-to-face interviews. Thematic analysis was used to code the transcribed data and group alike findings into sub-categories, which were collapsed to four major categories and one overarching core finding. These were mapped to a matrix combining the COM-B and TDF to establish the usability of these tools in midwifery contexts.

Results
Four major categories were developed from the data collected in this study. Three reported the hindrances midwives’ experienced when trying to initiate new EBPs: ‘For midwives, medical opposition and workplace culture are the biggest challenges’, ‘Fear can stop change: it’s personal for midwives’ and ‘Midwives are tired of fighting the battle for EBP; they need knowledge and the confidence to bring about practice change.’ The other major category highlighted factors midwives’ considered helpers of EBP: ‘Having stakeholder buy-in and strong midwifery leadership is a huge advantage.’ When mapped to the TDF and COM-B, these findings provided valuable insight into the helpers of and hindrances to evidence-based practice in midwifery.

Conclusion
Midwives are motivated to initiate evidence-based change yet have limited knowledge of implementation processes or the confidence to lead practice change. Factors such as inter-disciplinary buy-in, clear instruction for midwives and support from midwifery leaders were considered beneficial to implementing practice change in clinical areas. The TDF when used in combination with the COM-B was deemed useful to midwives wanting to lead practice change projects in clinical areas.
Obstetric near misses among women with serious mental illness: data linkage cohort study
Authors: Easter Abigail , Sandall Jane , Howard Louise M. 
Published: January 2021

BackgroundInvestigating obstetric near misses (life-threatening obstetric complications) provides crucial information to prevent maternal mortality and morbidity.AimsTo investigate the rate and type of obstetric near misses among women with serious mental illness (SMI).MethodWe conducted a historical cohort study, using de-identified electronic mental health records linked with maternity data from Hospital Episode Statistics. The English Maternal Morbidity Outcome Indicator was used to identify obstetric near misses at the time of delivery in two cohorts: (1) exposed cohort – all women with a live or still birth in 2007–2016, and a history of secondary mental healthcare before delivery in south-east London (n = 13 570); (2) unexposed cohort – all women with a live or still birth in 2007–2016, resident within south-east London, with no history of mental healthcare before delivery (n = 223 274).ResultsThe rate of obstetric near misses was 884.3/100 000 (95% CI 733.2–1057.4) maternities in the exposed group compared with 575.1/100 000 (95% CI 544.0–607.4) maternities in the unexposed group (adjusted odds ratio 1.6, 95% CI 1.3–2.0, P < 0.001). Highest risks were for acute renal failure (adjusted odds ratio 2.1, 95% CI 1.1–3.8, P = 0.022); cardiac arrest, failure or infarction (adjusted odds ratio 2.3, 95% CI 1.1–4.8, P = 0.028); and obstetric embolism (adjusted odds ratio 3.1, 95% CI 1.6–5.8, P < 0.001).ConclusionsFindings emphasise the importance of integrated physical and mental healthcare before and during pregnancy for women with SMI.
Videoconference Intervention for Distance Caregivers of Patients With Cancer: A Randomized Controlled Trial
Authors: Douglas Sara L. , Mazanec Polly , Lipson Amy R. , Day Kim , Blackstone Eric , Bajor David L. , Saltzman Joel , Krishnamurthi Smitha 
Published: January 2021

PURPOSE: Approximately 20% of caregivers (CGs) live > 1 hour away from the patient and are considered distance caregivers (DCGs) who often report higher distress and anxiety than local CGs. The purpose of this study was to test the effectiveness of an intervention aimed at reducing anxiety and distress in DCGs of patients with cancer. METHODS: This randomized controlled trial enrolled DCGs of patients with all cancer types who were being seen monthly by oncologists in outpatient clinics. There were three arms of the intervention delivered over a 4-month period: arm 1 (a) received 4 monthly videoconference-tailored coaching sessions with an advanced practice nurse or social worker focused on information and support, (b) participated in patient’s appointments with the oncologist via videoconference over the 4-month study period, and (c) had access to a website designed for DCGs. Arm 2 did not receive the coaching sessions but received the other two components, and arm 3 received access to the DCG website only. RESULTS: There were 302 DCGs who provided pre- and postintervention data. There were significant anxiety by group ( P = .028 and r = 0.16) and distress by group interactions ( P = .014 and r = 0.17). Arm 1 had the greatest percentage of DCGs who demonstrated improvement in anxiety (18.6%) and distress (25.2%). CONCLUSION: Coaching and use of videoconference technology (to join the DCG into the patient-oncologist office visit) were effective in reducing both anxiety and distress for DCGs. These components could be considered for local CGs who—with COVID-19—are unable to accompany the patient to oncologist visits.