bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastrodin represses hydrogen peroxide-induced oxidative stress in retinal pigment epithelial cells through p38MAPK/iNOS pathway
Authors: Zhou Xingli , Zhao Ximing 
Published: November 2021

Elevated reactive oxygen species (ROS) induce oxidative damage in retinal pigment epithelium (RPE) and contribute to the development of age-related macular degeneration (AMD). Gastrodin plays an antioxidant role in distinct diseases, such as epilepsy, cerebral ischemia, Alzheimer’s disease, and cardiovascular diseases. However, the function of gastrodin in AMD remains unclear. Human RPE (ARPE-19) cells were incubated with 300 μM hydrogen peroxide (H2O2) for 24 hours. The results showed that H2O2 decreased cell viability and promoted the cell apoptosis of ARPE-19 cells. H2O2-induced ARPE-19 cells were then treated with different concentrations of gastrodin. Gastrodin increased cell viability of H2O2-induced ARPE-19 cells, suppressed the cell apoptosis of H2O2-induced ARPE-19 cells with reduced B-cell lymphoma (Bcl)-2 like protein (Bax), and enhanced Bcl-2. The levels of ROS were enhanced, malondialdehyde (MDA) was up-regulated, and superoxide dismutase (SOD) and glutathione (GSH) were down-regulated in H2O2-induced ARPE-19 cells. However, gastrodin reduced the levels of ROS and MDA and elevated SOD and GSH in H2O2-induced ARPE-19 cells. Furthermore, H2O2-induced increase of inducible nitric oxide synthase (iNOS) and p-p38 proteins in ARPE-19 was reversed by gastrodin. In conclusion, gastrodin exerted antiapoptotic and antioxidant capacities to protect against H2O2-induced oxidative stress in RPE, thereby acting as a potential agent for managing AMD.
A comparative clinical study on the effect of virechana karma and panchtikta pancha prashritika basti karma in the management of prameha w.s.r. to type ii diabetes
Authors: Pandey Rajeev Kumar , Bhatted Santosh kumar 
Published: November 2021

is a chronic disorder of origin with the vitiation of various body elements like and Diabetes mellitus is similar to which is a subtype of Here the patient voids excessive quantity of urine having concordance with with sweet taste. Insulin and other oral hypoglycaemic drugs are associated with several side effects and they have limited role in preventing the complications like neuropathy, nephropathy, retinopathy etc. Hence an ideal therapy which corrects the basic pathology and prevents the progress of the disease and complications is the need of time. So The explained in Ayurveda seems to be an appropriate solution for the treatment of Prameha.Aacharya Charaka and Sushruta has advised for here accumulate in the lower part of the body owing to the incompetence of the The major factor involved in the of are the in general and in particular hence to remove the and to eliminate the from nearest root is best. is best to improve Agni and is the best treatment to correct Vata.The present clinical study was conducted to evaluate the efficacy of Virechana karma and Basti karma in 90 patients (equally distributed in three group) of diagnosed case of Madhumeha for periods of 3 month. Group comparison was done by ANNOVA test showed that the Virechana was found better to reduce FBS and PPP Basti was found better to reduce PPBS
Efficacy of Terminalia chebula) and exercise in management of obesity (Sthaulya) — A case report
Authors: Joshi Mrudula Vinayak , Kedar Snehal Subhash , Prabhudesai Tejaswini Radhakrishna 
Published: November 2021

Obesity or is one of the lifestyle disorders rapidly increasing in the community; due to rigorously changing dietary habits and behavioural pattern. is a state of increased ofmeta data i.e. abnormal and /or excessive fat accumulation that may impair health of an individual. A married woman aged 29 years, presented to the clinic with complaint of infertility, loss of appetite and increased body weight. Regular walking exercise, as medicine along with counseling for diet restrictions made her lose 7.15% of her body weight with BMI reduction up to 2.94 units. Obesity is a public health problem with multiple risk factors and so its management is also very complex. Essential calorie intake coupled with appropriate adequate physical exercise and proper adherence to Ayurved guidelines for (daily regimen) can reduce rising problem of obesity in society.
Adult Male’s Penile Size Measurement and Its Affecting Factors
Authors: Wijanarko Mikhael San Putra , Stella Cathelin , Oktavianto Gian 
Published: November 2021

Background: In the general population, it is estimated that 91% of adult males perceive their penile size to be smaller than average. Concern about penile size can affect one’s self-esteem, which then affects its sexual function, satisfaction, as well as physical and mental health. Therefore, accurate penile measurements are needed for clinical and academic purposes.
Reviews: Measurement of penile size can be performed in an erect, stretched, even flaccid condition. However, from various researches, there is no standardization of such a measurement method. Various researches have carried out average penile measurement but many factors can affect these results such as race, genital conditions, systemic diseases, surgical procedures, and aging.
Summary: There is no internationally agreed way of measuring an adult male's penis and many other factors can make the results of penile measurements vary. Proper measurement and finding out the right average of penile size in adult male with regard to other affecting factors, will be indispensable for both clinical and academic purposes.
Exploring the Determinants of Intention to Quit and Awareness Regarding Ill Effects and Control Policies of Tobacco among Health Workers of a Tertiary Care Hospital in North India
Authors: Prasad Nidhi , Bharati Dharamvir Ranjan , Choudhary Sanjay Kumar , Kumar Binay 
Published: November 2021

Introduction: Sociodemographic factor, awareness of the health effects and legislative law can lead to an increase in cessation of tobacco. Tobacco related knowledge and awareness are found to be better in people working in the health care sector as compared to the general population. The objective of the study was to find the prevalence of quitting rate amongst the health workers and perceived harmful effects on health, tobacco types and awareness of the anti -smoking legislation law in India among the health care workers working in a tertiary care hospital. Methods: A cross-sectional study was conducted among 306 hospital staff (196 housekeeping staff and 110 nursing orderlies) at a tertiary care hospital of Faridabad in 2018. Convenience sampling was conducted, and data were collected through pre tested semi structured questionnaires on sociodemographic details, awareness of ill effects of tobacco and intention to quit. Results: Among 133 current tobacco users, intention to quit smoking was present in only 96 respondents (72.18%). There was association between age, marital status and type of family with the intention to quit. 63 respondents (21%) were unaware that smoking causes lung cancer and 115 (38%) of the total respondents did not consider smokeless tobacco as a causal risk factor for cancer. A total of 180 respondents (58.8%) were not aware of anti-tobacco control laws in India. Moreover, it was found that health concern was commonest reason of intention to quit. Conclusions: Intention to quit tobacco among study participants was low, so there is need to look for knowledge gaps about harms of different types of products and anti-tobacco legislation. More comprehensive tobacco cessation services should also be prioritized in the heath sector.Keywords: awareness of ill effects, COTPA, India, intention to quit, tobacco
BONE ALUMINUM AS A BIOLOGICAL MONITORING OF OCCUPATIONAL EXPOSURE TO ALUMINUM
Authors: Monintja Keyne Christa , Ilyas Muhammad 
Published: November 2021

ABSTRACTThe current proposed biological monitoring of aluminum is based on the analysis of aluminum concentration in blood/serum or in urine, but both considered to be reflective of short-term exposure. Based on its toxic kinetics, aluminum has been demonstrated to be accumulated in the bone. The aim of this study is to find out whether by analyzing bone aluminum, we might have an overview of aluminum accumulation that might cause health problems in the future. This review was conducted through a method of search and selection of articles from Pubmed, Cochrane Library, and Google Scholar databases aimed to answer question rising from the problem statement of this study. The process of searching articles used the keywords “occupational aluminum” OR “bone aluminum” AND “biological monitoring” OR “biomonitoring”. The selection of articles was performed using the defined inclusion and exclusion criteria. Initially, 61 articles were obtained, but after the selection process and hand searching, four articles remained consisting of two case reports and two cross sectional studies. Based on the selected evidence-based resources, bone can be a promising potential biomarker of aluminum, especially for cumulative exposure assessment. The use of in vivo neutron activation analysis (IVNAA) or X-ray fluorescence (XRF) technology for the purpose of noninvasively quantifying aluminum concentration in the bone, is suitable enough to be performed in occupational settings. Keywords: Bone aluminum, occupational exposure, IVNAA, XRF, biomonitoring, biological monitoring
THE CORRELATION AVAILABILITY NURSES AND EQUIPMENT WITH ACUTE MISSED NURSING CARE AT HOSPITALS
Authors: Putra Kuswantoro Rusca , Dewi Fajar Mulia , Rahmayanti Asih Devi , Budiati Ani 
Published: November 2021

Background: One of the nurse’s roles is to provide nursing care regards of patient safety, consistently and timely. The availability of nurses and equipment can be considered as a primary constraint contributing to acute missed nursing care.Aims: This study aimed to determine the correlation between the availability of nurses and equipment with incidences of acute missed nursing care in medical and surgical wards at hospitals.Methods: This study used quantitative research with a cross sectional approach. This research was conducted at six private hospitals in Malang from October 2020 to November 2020. The population in this study were selected using consecutive sampling, and the study sample consisted of 206 nurses. The acute MISSCARE Survey was used to collect data. The relationship between the availability of the number of nurses and equipment with acute missed nursing care was analyzed by applying SPSS version 26 with the Spearman test.Results: The relationship between the availability of nurses and acute missed nursing care yielded results of ρ = 0.016 (<0.05) and R = -0.168. Equipment availability and acute missed nursing care had values of ρ = 0.026 (<0.05), and R = -0.155. This shows correlation between the availability of the number of nurses and equipment with incidences of acute missed nursing care.Conclusion: The availability of the number of nurses and equipment are the reasons for the incidence of acute missed nursing care. Therefore, nursing managers are needed in managing and allocating the necessary number of nurses and equipment.Keywords: equipment, missed nursing care, nurse
Eric Weil e la «fine della storia»
Authors: Raimondi Edoardo 
Published: November 2021

O artigo visa mostrar como Eric Weil (1904-1977) recompreendeu a famosa tese do “fim da história”, elaborada por Alexandre Kojève (1902-1968) desde os anos de 1930, propondo uma nova versão de caráter essencialmente “kantiano pós-hegeliano”: um elemento teórico fundamental do inter histórico- filosófico weiliano, que emergiria claramente dos estudos específicos sobre Kant aos quais Weil se dedicou de modo pontual a partir da década de 1960. Veremos, portanto, como as reviravoltas “práticas” de tal recompreensão tenham de fato indicado a estrada para a constituição de uma nova filosofia política, eminentemente crítica e antidogmática.
Revised Maximum Depositional Age for the Ediacaran Browns Hole Formation: Implications for Western Laurentia Neoproterozoic Stratigraphy
Authors: Provow Ashley W. , Newell Dennis L. , Dehler Carol M. , Ault Alexis K. , Yonkee W. Adolph , Thomson Stuart N. , Mahan Kevin H. 
Published: November 2021

AbstractConstraining the depositional age of Neoproterozoic stratigraphy in the North American Cordilleran margin informs global connections of major climatic and tectonic events in deep time. Making these correlations is challenging due to a paucity of existing geochronological data and adequate material for absolute age control in key stratigraphic sequences. The late Ediacaran Browns Hole Formation in the Brigham Group of northern Utah, USA, provides a key chronological benchmark on Neoproterozoic stratigraphy. This unit locally comprises &lt;140 m of volcaniclastic rocks with interbedded mafic-volcanic flows that lie within a 3500 m thick package of strata preserving the Cryogenian, Ediacaran, and the lowermost Cambrian history of this area. Prior efforts to constrain the age of the Browns Hole Formation yielded uncertain and conflicting results. Here, we report new laser-ablation-inductively-coupled-mass-spectrometry U-Pb geochronologic data from detrital apatite grains to refine the maximum depositional age of the volcanic member of the Browns Hole Formation to 613±12 Ma (2σ). Apatite crystals are euhedral and pristine and define a single date population, indicating they are likely proximally sourced. These data place new constraints on the timing and tempo of deposition of underlying and overlying units. Owing to unresolved interpretations for the age of underlying Cryogenian stratigraphy, our new date brackets two potential Brigham Group accumulation rate scenarios for ~1400 m of preserved strata: ~38 mm/kyr over ~37 Myr or ~64 mm/kyr over ~22 Myr. These results suggest that the origins of regional unconformities at the base of the Inkom Formation, previously attributed to either the Marinoan or Gaskiers global glaciation events, should be revisited. Our paired sedimentological and geochronology data inform the timing of rift-related magmatism and sedimentation near the western margin of Laurentia.
Technical Solution Improves Safety, Efficiency of Well Construction Offshore Australia
Authors: Carpenter Chris 
Published: November 2021

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 202353, “Drilling-Performance and Risk-Management Optimization Offshore Australia: Improving Overall Safety and Efficiency of the Well-Construction Process,” by Chandrasekhar Kirthi Singam, Farshid Hafezi, and Clyde Rebello, Schlumberger, et al., prepared for the 2020 SPE Asia Pacific Oil and Gas Conference and Exhibition, originally scheduled to be held in Perth, Australia, 20–22 October. The paper has not been peer reviewed.
The emergence of real-time well construction performance-monitoring centers has improved the service delivery for operators across numerous offshore oil fields in Australia significantly. The complete paper details new technologies and work flows implemented for three Australian offshore wells, with the primary objective of improving drilling efficiency while managing associated risks. Additional objectives included optimizing daily operational performance, thus delivering time savings for the operator and highlighting areas of possible improvements.

Introduction
The paper describes a successful drilling campaign in a challenging field in the Timor Sea. It describes how data analysis, risk evaluation, and real-time performance monitoring can be influential in saving rig time and project success. As part of this project, a major operator in Australia decided to perform an infill drilling campaign involving three high-angle directional wells (J type) in a saturated, complex field. The campaign design stage was initiated in 2017 with a main objective of delivering the project within authority-for-expenditure (AFE) budget and with planning for all potential challenges.

Technical Overview
The technical solution (Fig. 1) was deployed using drilling-interpretation software and executed its work flows to achieve the required objectives.
Development of Corrosion Inhibitors to Mitigate Elemental Sulfur Induced Pitting Corrosion
Authors: Dickey Douglas C. , Obeyesekere Nihal U. Obeyesekere , Wylde Jonathan J. 
Published: November 2021

Abstract
The effects of elemental sulfur on the corrosion of mild steel is a serious problem in the oil & gas industry costing millions of dollars annually in lost production and assets.
Mitigating the corrosive effects of elemental sulfur on mild steel in the oil and gas industry is a challenge and finding a viable solution would provide a more cost effective and safer working environment and as well as be environmentally conscious. Currently, there are no highly effective products for elemental sulfur corrosion in the marketplace.
More than fifty new chemical formulations were blended and screened by rotating cylinder electrode method (RCE). These formulations were tested in the presence of 0.1% elemental sulfur in mildly sour conditions. The promising candidates were identified and tested again in the presence of elemental sulfur under the same mildly sour conditions.
The most promising candidates from the initial screening were then subjected to rotating cage autoclave (RCA) testing for extended periods of time in the presence of 0.1% and 0.15% elemental sulfur. The general corrosion rates were calculated via weight loss and the metal surfaces were examined under a high-power digital microscope for pitting and localized corrosion.
A detailed analysis of the above testing yields promising results. The results from the testing show that formulations mitigate pitting in environments containing elemental sulfur. In less harsh conditions, such as low chloride brines or low CO2 environment, formulations seem to provide excellent protection against general corrosion while mitigating pitting due to elemental sulfur. In more extreme environments such as harsh brines with elevated chloride levels, high hydrogen sulfide and CO2 levels, the formulations mitigate pitting but need further development in inhibiting general corrosion The best product currently developed inhibits corrosion and pitting in the presence of elemental sulfur in various conditions and performs well against elemental sulfur in more aggressive sour systems. We are currently improving the performance against elemental sulfur and developing chemistries to mitigate polysulfide induced corrosion in sour systems.
This paper describes the development of effective inhibitors for corrosion and pitting in the presence of elemental sulfur under sour conditions. This study focuses more on pitting corrosion due to the corrosive characteristics of elemental sulfur than on uniform general corrosion. The general corrosion with the selected inhibitor was highly mitigated and was less than 3.0 mpy while yielding excellent protection against sulfur induced pitting.
Turbulence Leads to Overestimation of the Acid-Diffusion Coefficient at Typical Experimental Conditions Using the Rotating Disk Apparatus
Authors: Ivanishin Igor , Kotb Abdelrahman , Nasr-El-Din Hisham 
Published: November 2021

Abstract
A rotating-disk apparatus (RDA) is used to determine the acid-diffusion coefficient. The equations to interpret RDA tests were previously derived assuming laminar flow to the disk, i.e. uniform accessibility with equal flux of the reactive species over the entire surface of the disk. Thus, the acid-diffusion coefficient is overestimated if the tests are run at transition or turbulent flow regimes. The present work validated laminar flow assumptions at typical RDA experimental conditions to optimize the acid-diffusion coefficient measurements. Disks of calcite marble with a diameter of 0.72, 1.11, and 1.46 in. were reacted in an RDA with hydrochloric acid at temperatures ranging from 73.4 to 100°F and disk rotational speeds ranging from 207 to 1,555 rpm. Transition to turbulent flow was observed at Reynolds numbers one order of magnitude lower than the universally accepted critical value of 3×105. Dissolution patterns on the disks after the experiments and the simulation results using a developed computational fluid-dynamics model confirm this conclusion.
The turbulence created cavities near the edges of the 1.46 and 1.1 in. disks starting at rotational speeds of 587 and 829 rpm, respectively. The region of turbulent flow propagated toward the center of the disks with further increase of disk rotational speed. Because of the non-uniform (higher) mass-transfer rate, the diffusion coefficient is overestimated to a value of 6.71×10−5 and 5.01×10−5 cm2/s for the 1.46 and 1.11 in. disks, respectively. For the 0.72 in. disks, no turbulent flow was observed at all disk rotational speeds tested, and the calculated value of the diffusion coefficient was 3.08×10-5 cm2/s. Commercial RDA setups are often equipped with 1.0 or 1.5 in. coreholders and are capable of maintaining a disk rotational speed of up to 2,000 rpm. Thus, care must be taken not to run the tests at transition or turbulent flow regimes, as this will result in overestimation of the acid-diffusion coefficient. Preliminary results indicate that the observed phenomena also affect the RDA analysis of organic and other less reactive acid compositions. Presented results are integral for designing the RDA tests to improve the accuracy of the acid-diffusion coefficient calculations.
Triazine Polymers for Improving Elastic Properties in Oil Well Cements
Authors: Patel Hasmukh , Johnson Kenneth , Martinez Roland 
Published: November 2021

Abstract
The oil well cement placed in the annulus between casings and the formations experience high stresses under downhole conditions. These frequent stresses deteriorate the mechanical properties of cement and lead to the formation of micro-cracks and fractures, which affect production and increases the cost of operation. Although several polymeric materials have been employed to improve tensile properties of the cement, these additives have also adversely affected the compressive strength of the cement. A highly stable polymeric additive, triazine-based polymers, is designed, synthesized, and compounded with the cement to improve the tensile properties of the well-cement. Triazine polymer was characterized by fourier transform infrared spectroscopy and thermogravimetric analysis. The triazine polymer was mixed with cement and the cement slurries were cured at 180 °F under 3000 psi for 3 days. The set-cement samples were subjected to mechanical testing under high temperature and high pressure to study the elastic properties of the cement. The introduction of this polymer into the cement has improved the elastic properties of the cement with minimum reduction in compressive strength. The thickening time, dynamic compressive strength development, rheology, fluid loss properties, and brazilian tensile strength of the control and cement with triazine polymers were studied to understand the effect of this newly developed polymeric additive. The molecular interaction of the triazine polymer with cement particles has shown formation of covalent linkage between the polymer and cement particle. We have observed a 15 % decrease in Young's modulus for cement compounded with 2%wt. of triazine polymer, indicating the introduction of elastic properties in wellbore cement.