bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Synthesis, Tautomerism, Molecular Docking And Biological Evaluation of 4-Hydroxy-3-(3-Oxo-1-Phenylbutyl)-2H-Chromen-2-One Analogues
Authors: Afzal Zakia , Rashid Naghmana , Nadeem Humaira , Khan Arif-ullah 
Published: November 2021

Abstract
Keeping in view the aim of better alternatives of 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one (warfarin), eleven analogs of warfarin have been synthesized with the goal to increase enantioselectivity of (S) enantiomer by using appropriate catalyst and minimize tautomerism by replacing methyl group of the side chain with aryl group. There are many reports of the serious complications with warfarin use, which are associated with the tautomeric forms of warfarin. The key step was highly enantioselective Michael addition of variously substituted chalcone and 4-hydroxycoumarin by using cinchona based 9-amino-9-deoxyepiquinine as chiral catalyst. Synthesized compounds were characterized by IR, 1HNMR,13CNMR, EIMS and CD studies. Enantiomeric excess (%ee) was determined by chiral HPLC which was upto 98%. Synthesized analogues were screened for anticoagulant, antibacterial and antifungal activities. In-vitro anticoagulant activity was evaluated by plasma recalcification time (PRT) method and out of eleven, ten synthesized compounds showed improved IC50 values as compaired to IC50 values of standard drug warfarin. Compound 4 showed 68.25% inhibation against staphylococcus aureus and compound 7 showed 68% inhibation against bacillus subtillis, gram positive strains of bacteria, compound 6 shows 70% inhibation against fungal strain candida albicans. Furthermore, molecular docking studies were carried out with Vitamin K1 epoxide reductase VKOR1 receptor 3kp9, a potential target of warfarin for anticoagulant activity.
A Bibliometric Analysis of the 100 Most Cited Articles on Adjacent Segment Degeneration in Worldwide from 1985 to 2021
Authors: Zhou Lijin , Cheng Yunzhong , Hai Yong , Liu Yuzeng , Li Yue , Lu Hongyi 
Published: November 2021

Abstract
Study design.A bibliometric review of the literature.Objective.The objective of our study is to research and analyze the most frequently cited 100 articles on adjacent segment degeneration (ASD).Background.Fusion is an effective method for degenerative diseases, however the problem of adjacent segment degeneration (ASD) after the fusion are also becoming increasingly important. Numerous of literatures and related researches promoted the development of this field. A bibliometric analysis of the 100 most cited articles on adjacent segment degeneration can supply lots of information and guide the future researches.Methods.We searched and identified the100 top-cited articles from Web of Science (WOS), using title-specific search“adjacent segment degeneration”. All articles published in English language between 1985 and 2021 were included. The following information were recorded and analyzed with bibliometric method: first author, article title, journal of publication, year of publication, total number of citations, country, institution and authors’ specialty.Results.The most prolific years were 2015 and 2016, each had 12 articles published. The most citation years were 2020 and 2018, which the total citations were 522 and 438, respectively. The citation count of the top 50 articles ranged from 22 to 421. European Spine Journal contributed the maximum of 17 articles. With regard to the primary author’s specialty, clinical neurology contributed to the majority of top 100 list with 75 articles, SHEN Y published the most of 5 articles. China mainland had produced 29 articles in the first. With regard to institutions, the most one was from Yonsei University with 8 articles.Conclusion.This study searched and analyzed the top 100 influential articles on ASD and provided a meaningful resource with detailed information for spine surgeons who may much more better to understand the trend in this filed. They can also benefit from the emphasis on citation count to prepare high-level articles by themselves in the future.
Biological And Chemical Properties of Cured Epoxy Resins
Authors: Rudawska Anna , Sarna-Boś Katarzyna , Rudawska Adrianna , Różyło-Kalinowska Ingrid , Chałas Renata 
Published: November 2021

Abstract
Introduction: Launched into production over 50 years ago, epoxy resins aroused enormous interest owing to their valuable properties that distinguish them from other polymeric materials. The investigation of biological and chemical effects of direct exposure to the materials under study on the human body may help in the organization of work when dealing with this type of materials.Objectives: The objective of this study is to investigate selected biological and chemical properties of 3 cured epoxy compounds: Epidian 53 epoxy resin with polyaminoamide C curing agent, Epidian 53 epoxy resin with polyaminoamide C curing agent, and aluminum powder, and Epidian 53 epoxy resin with polyaminoamide C curing agent, and copper powder. Methods: The experimental part of this paper describes the preparation and fabrication of adhesive compound samples, from a liquid state to cured plates. The study involved a cytotoxicity analysis (with an ELSA reader), pH measurements (with a pH meter), absorbance measurement over an entire reference wavelength range, and sterilization (on a specially designed test bench) along with microscopic examination of its effects.Results: Cytotoxicity and absorbance analysis results demonstrate that extracts of all tested resin samples do not have cytotoxic effect on the cells of living organisms. The absorbance results over the wavelength range do not indicate the formation of aggregations, which proves that no toxic agents harmful to living organisms are extracted from the resin samples.Conclusion: Results of this study demonstrate that cured epoxy resins are safe materials.
Distribution Characteristics Of New AO Classification In Different Age Groups Of Patients With Femoral Neck Fracture
Authors: Jiang Yuxuan , Zhu Yangjun , Feng Dongxu , Huang Wei , Jiang Wuqiang , Wang Xiaolong 
Published: November 2021

Abstract
Objective
The clinical and imaging data of patients diagnosed with femoral neck fractures (FNFs) in Xi 'an Honghui Hospital from 2018 to 2020.The epidemiological characteristics of these patients in different age groups were analyzed.
Methods
In this study, patients with femoral neck fracture hospitalized in Xi 'an Honghui Hospital from January 2018 to January 2021 were divided into four groups according to age: the young group (≤44 years old), the middle-aged group (45-59 years old),the young old group (60-74 years old), and the elderly group (≥75 years old) to analyze age,sex,side,injury mechanism,new AO classification and other features. A total of 2071 patients were included for analysis.
Results
There were 742 males (35.8%) and 1,329 females (64.2%).There were 1,106 patient s(53.4%) on the left side and 965 on the right side (46.6%).There were 1781 cases of low energy injury (86%) and 290 cases of high energy injury (14%), and the main injury mechanism was falling.The number of patients with femoral neck fracture in each year was 719 patients in 2018, 694 patients in 2019, and 661 patients in 2020, respectively. The number of patients showed a decreasing trend year by year, and the gender ratio and injury mechanism showed no significant trend of change. In the age group, the proportion of the young group was increasing year by year.Among the new AO classification, there were 1023 cases of B1.3, accounting for the highest proportion of 49.4%.The proportion of B2.2 was the highest in the young group (32.4%) .B1.3 and B2.2 were the main types in the middle-aged group, accounting for 31.7% and 32.0, respectively.B1.3 was dominant in the young old and elderly group (47.1% and 63.4%, respectively).
Conclusion
The new classification combines the classic classification, which is easier to remember. The stability of fracture is more carefully distinguished,which is conducive to guiding the surgical treatment of many stable femoral neck fractures in middle-aged and young old people. ORIF treatment can be used to delay the age of hip replacement.
Notch/NICD/RBP-J Signaling Axis Regulates M1 Polarization of Macrophages Mediated by Advanced Glycation End Products
Authors: Tan Hao , Xu Wenjie , Ding Xiaoqian , Ye Huayu , Hu Yun , He Xinyi , Ming Ye , Zheng Leilei 
Published: November 2021

Abstract
Advanced glycation end products (AGEs) aggregation and macrophages polarization both play essential roles in degenerative bone diseases caused by aging or diabetes, such as senile or diabetic osteoporosis. Here, we aimed to understand the involvement and potential mechanism of AGEs in macrophages polarization and osteoclastogenesis. We found that RAW264.7 macrophages treated with AGEs highly expressed M1-associated genes and surface antigen markers CD86, and released a large amount of NO to the extracellular environment. Through the detection of osteoclast-related markers and TRAP staining, we revealed that the osteoclastogenesis of M1 macrophages could be markedly enhanced by AGEs. To explore the potential mechanisms of AGEs-mediated M1 polarization, we first demonstrated that AGEs effectively activated the transduction of Notch signaling pathway, including nuclear translocation of NICD1. Subsequently, it was observed that the M1 polarization effects induced by AGEs were significantly mitigated, when γ-secretase inhibitor DAPT and siRNA targeting silencing RBP-J were applied to block the signal transduction of Notch. In conclusion, our findings revealed a series of phenomena that AGEs induce macrophage M1 polarization and enhance its osteoclastogenesis ability, and Notch/NICD/RBP-J signaling axis is involved in the regulation of this polarization process.
Clock Gene Regulates Kainic Acid-Induced Seizures Through Inhibiting Ferroptosis in Mice
Authors: Wang Fei , Guo Lianxia , Wu Zhengping , Zhang Tianpeng , Dong Dong , Wu Baojian 
Published: November 2021

Abstract
Temporal lobe epilepsy (TLE) is a common and intractable form of epilepsy. There is a strong need to better understand molecular events underlying TLE and to find novel therapeutic agents. Here we aimed to investigate the role of Clock gene and ferroptosis in regulating TLE. TLE model was established by treating mice with kainic acid (KA). Regulatory effects of Clock gene on KA-induced seizures and ferroptosis were evaluated using Clock knockout (Clock−/−) mice. mRNA and protein levels were determined by quantitative real-time PCR and western blotting, respectively. Ferroptosis was assessed by measuring the levels of iron, GSH and ROS. Transcriptional regulation was studied using a combination of luciferase reporter, mobility shift and chromatin immunoprecipitation (ChIP) assays. We found that Clock ablation exacerbated KA-induced seizures in mice, accompanied by enhanced ferroptosis in the hippocampus. Furthermore, Clock ablation reduced the hippocampal expression of GPX4 and PPAR-γ, two ferroptosis-inhibitory factors, in mice and in N2a cells. Moreover, Clock regulates diurnal expression of GPX4 and PPAR-γ in mouse hippocampus and rhythmicity in KA-induced seizures. Consistently, Clock overexpression up-regulated GPX4 and PPAR-γ, and protected against ferroptosis in N2a cells. In addition, based on luciferase reporter, mobility shift and ChIP assays, we uncovered that CLOCK protein trans-activated Gpx4 and Ppar-γ through specific binding to an E-box element in gene promoters. In conclusion, CLOCK protests against KA-induced seizures through promoting expression of GPX4 and PPAR-γ and inhibiting ferroptosis.
PENGARUH KEPEMILIKAN SAHAM, ROI, TOTAL ASET, DAN DIVIDEN TERHADAP DAR PADA PERUSAHAAN PT MEDIA NUSANTARA CITRA Tbk TAHUN 2011-2019
Authors: Saharani Devi , Hapsari Mega Tunjung 
Published: November 2021

Abstrak: Penelitian ini berfokus pada permasalahan pengambilan kebijakan utang perusahaan PT Media Nusantara Citra Tbk yang meliputi kebijakan dividen, profitabilitas, struktur kepemilikan, dan ukuran perusahaan. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian asosiatif. Metode pengumpulan data menggunakan metode studi pustaka dan dokumentasi. Teknik pengambilan sampel menggunakan metode purposive sampling. Data yang digunakan yaitu data sekunder yang diperoleh dari laporan keuangan triwulan PT Media Nusantara Citra Tbk tahun 2011-2019. Penelitian ini menggunakan analisis regresi linier berganda melalui SPSS. Hasil penelitian menunjukkan bahwa secara parsial variabel kepemilikan saham dan total aset berpengaruh positif dan signifikan terhadap DAR. Sedangkan variabel ROI dan dividen berpengaruh negatif dan signifikan terhadap DAR. Sementara, secara simultan variabel kepemilikan saham, ROI, total aset, dan dividen memiliki pengaruh yang signifikan terhadap DAR pada PT Media Nusantara Citra Tbk Tahun 2011-2019.
Kata Kunci: Kepemilikan Saham; Total Aset; ROI; Dividen; DAR.

Abstract: This research focuses on the problem of PT Media Nusantara Citra Tbk debt policy-making which includes dividend policy, profitability, ownership structure, and company SIZE. This research uses a quantitative approach with an associative research type. Data collection methods using a library and documentation study methods. Sampling techniques using a purposive sampling method. The data used is secondary data obtained from PT Media Nusantara Citra quarterly financial report for 2011-2019. This study used multiple linear regression analysis with SPSS. The results showed that partially variable shareholding and total assets had a positive and significant effect on DAR. Meanwhile, variable ROI and dividends have a negative and significant effect on DAR. Meanwhile, simultaneously variable shareholding, ROI, total asset, and dividend have a significant influence on DAR at PT Media Nusantara Citra Tbk The year 2011-2019.
Keywords: Shareholding; Total Assets; ROI; Dividend; DAR.
Prospects for the drug use based on common ivy for bronchopulmonary pathology in childhood
Authors: Mizernitskiy Yu. L. , Dorovskaya N. L. , Melnikova I. M. 
Published: November 2021

Respiratory diseases persistently lead in the structure of general morbidity in both children and adolescents. Acute respiratory infections are the most common among them. Interest of pediatricians to phytotherapy is not accidental and is due to the fact that it has a mild therapeutic effect, enhances the effectiveness of complex therapy, has few side effects. Of particular interest are herbal remedies containing ivy extract (Hedera helix), the active ingredients are mainly found in ivy leaves, they are biologically active substances: Triterpene saponins, glycosides, also contain carbohydrates, essential oils, steroids, phenolcarboxylic acids, coumarins, flavonoids, carotenoids, tocopherols (vitamin E), B and C vitamins, tannins, phytoncides. Ivy preparations are prescribed as an expectorant in the treatment of infectious and inflammatory diseases of the upper and lower respiratory tract due to their proven multidirectional effects: secretolytic, mucolytic, bronchospasmolytic. They also have anti-inflammatory, reparative, antioxidant effects.This article presents a clinical example of an officinal ivy-based preparation used in the treatment of a 3.5 year old patient diagnosed with acute respiratory viral infection. Temperature increased to 38 °C, runny nose; on the second day of illness the temperature remained subfebrile and a dry cough appeared. Nasal vasoconstrictor drops and oral acetylcysteine were prescribed, but there was no relief. On the third day of the illness, against the background of subfebrile temperature, the cough persisted, single dry rales were heard in the lungs, wheezing appeared during physical exertion. Acetylcysteine was withdrawn and replaced by ivy-based drops (16 drops 3 times a day orally after meals in a small amount of water). After 2 days the cough was moist, the sputum was easily expectorated, the wheezing in the lungs was almost gone, there was no more wheezing and the temperature was normal. By the sixth day of treatment the cough was gone and the girl had almost recovered. Nevertheless, Gedelix was continued for another 4 days. Prospective results and detailed study of the effects of herbal preparations on the basis of ivy extracts served as the basis for their recommendation as a complex therapy of cough in children.
Chronic Epstein-Barr viral infection in children: a clinical case
Authors: Kokoreva S. P. , Kotlova V. B. , Razuvaev O. A. 
Published: November 2021

The urgency of Epstein-Barr virus infection is explained by wide circulation of Epstein-Barr virus among children and adults, its tropism to immunocompetent cells with lifelong persistence after primary infection and polymorphism of clinical manifestations from subclinical forms, infectious mononucleosis to formation of oncological, autoimmune hematological diseases.Persistence of Epstein - Barr virus Leads to suppression of cellular immunity, decreased production of interferons and nonspecific protection factors, which contributes to reactivation of persistent infection, most often without mononucleosis-like syndrome, and the appearance of atypical mononuclears in blood with the formation of lymphoproliferative, intoxication, astheno-vegetative syndrome, long-term subfebrile condition, which dictates the need for immunocorrective therapy. This article presents a clinical case describing and analyzing the course of a chronic Epstein-Barr virus infection in a preschool child (5 years 8 months) with a pre-morbid background. Episodes of reactivation of chronic persistent infection occurred under the mask of acute respiratory infection with lymphoproliferative syndrome, purulent tonsillitis, purulent adenoiditis. Therapy, including antibiotics, short-course antiviral agents, bacterial lysates, and physiotherapy, had a temporary and short-lived effect. meglumine acridonacetate. The described clinical case demonstrates the effectiveness of the inclusion of meglumine acridonacetate, which has antiviral, immunomodulatory and anti-inflammatory effects, in the complex treatment of Epstein-Barr virus infection, This allowed to obtain fairly rapid positive clinical dynamics of relieving intoxication and febrile and lymphoproliferative syndromes in the acute period, and subsequently - astheno-vegetative syndrome and achieve the transition of active chronic Epstein - Barr virus infection into a latent form.
Management of children with allergic rhinitis in the practice of a local pediatrician
Authors: Koltuntceva I. V. , Gaiduk I. M. , Sakhno L. V. , Bairova S. V. 
Published: November 2021

Due to the increase in the weight of allergic diseases in the general pathology of childhood, the diagnosis and treatment of allergic rhinitis in children and the management of these patients at the outpatient stage have not lost their relevance. The period of preschool and school age is characterized by a high frequency of acute respiratory diseases of the upper respiratory tract, especially acute rhinitis, rhinopharyngitis, rhinosinusitis. This daily poses to the district pediatrician the tasks of differential diagnosis of allergic rhinitis and acute rhinitis with a prolonged course. Allergic rhinitis most often does not require hospitalization and, with timely diagnosis, does not lead to serious consequences. It is known that children who are prone to allergies suffer from acute respiratory viral infections more often and more severely than their peers. An integrated approach to the diagnosis and treatment of such children with the participation of an allergist, an otorhinolaryngologist, under the constant supervision of a district pediatrician, the rational use of drug therapy can reduce the duration of the disease, improve the quality of life of the patient.The article presents generalized principles of management of patients with allergic rhinitis from the point of view of domestic and international recommendations, describes in detail the rules of life for children with allergic rhinitis, emphasizes the role of the district pediatrician in teaching parents to ensure a hypoallergenic environment of the child. The authors present a clinical example of the effective use of a combined decognensant and an antihistamine for the treatment of acute respiratory viral infections in a child with allergic rhinitis.
Possibilities of inhalation bacteriophage therapy in treatment of children with acute tonsillitis
Authors: Turdieva Sh. T. , Nasirova G. R. , Ganiyeva D. K. 
Published: November 2021

Introduction. At the same time, in the last decade, pediatricians have increased interest in the study of the therapeutic effect of bacteriophages in infectious diseases of rhinolaryngological organs.Objective. The analysis of results of the use of inhalation bacteriophage therapy in children with acute tonsillitis, on an outpatient basis.Materials and methods. Examined 212 children from 4 to 15 years old with acute tonsillitis. Conducted general clinical research, pharyngoscopy, bacteriological examination of a smear of tonsils. Bacteriophage therapy carried out using the Pyobacteriophage complex liquid (PCL).Results. In the course of an objective clinical analysis, on the day of seeking outpatient care, patients noted asthenovegetative disorders in all patients (100%), in the form of general weakness (96.8%), loss of appetite (94.8%), and headache (92.5%). During the examination, cervical lymphadenopathy (98.6%), tonsil hyperemia and hyperplasia (98.1%), and exudates (48.1%) noted. It revealed that the main causative agents of acute tonsillitis in children were the bacteria Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae, with different relative proportions (from 24.2% to 59%). Inhalation bacteriophage therapy carried out from the first days of the disease. Against the background of therapy, it was noted - a decrease in swelling in the tonsils by 2-3 days with a decrease in general intoxication signs. On the 6th day from the beginning of bacteriophage therapy, asthenovegetative disorders stopped 2.2 times faster in relation to patients who did not receive bacteriophage therapy, against the background of a decrease in the manifestation of objective clinical signs of the disease.Conclusion. The use of inhalation bacteriophage therapy as part of the conservative treatment of acute tonsillitis in children contributes 1.4 times to the fastest relief of the acute period and an improvement in the subjective assessment of well-being is 25% higher concerning the comparison group.