bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Quality of Life for Children With Cerebral Palsy in Vietnam: Implementation of Intensive Models of Rehabilitation
Authors: Coker-Bolt Patricia , DeLuca Stephanie C. , Khánh Chi Hoàng , Tường Giao Lê Tường Lê , Nguyễn Thị Đang , Bich Ngoc Nguyen Thi 
Published: September 2021

Abstract
Date Presented 04/8/21
Vietnamese therapists developed constraint-induced movement therapy (CIMT) models and completed a prospective nonrandomized study at two hospitals in Vietnam. Therapists at Hanoi Rehab Hospital delivered a low-dose (30-hour) CIMT protocol, and therapists in Ho Chi Minh City Children's Hospital delivered a high-dose (72-hour) CIMT protocol. Children in both low- and high-dose CIMT groups showed improvements in everyday activities and individual therapy goals. This study advances the delivery of evidence-based practice in Vietnam.
Primary Author and Speaker: Patricia Coker-Bolt
Additional Authors and Speakers: Katherine Breithaupt
Contributing Authors: Lauren Williams
Durvalumab (Imfinzi)
Authors: Reimbursement Team  
Published: September 2021

CADTH recommends that Imfinzi should be reimbursed by public drug plans for the treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) if certain conditions are met.
Imfinzi should only be reimbursed if it is prescribed and monitored by clinicians who have been trained in oncology and immunotherapy, and if the price of Imfinzi is reduced.
Imfinzi should only be covered to treat adult patients who have not received previous treatment for ES-SCLC.
Pembrolizumab (Keytruda)
Authors: Reimbursement Team  
Published: September 2021

CADTH recommends that Keytruda (pembrolizumab) should be reimbursed as monotherapy for the first-line treatment of metastatic microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) colorectal cancer if certain conditions are met.
Keytruda should only be reimbursed if prescribed by clinicians with experience in immuno-oncology and treating colorectal cancer, and if the price of the drug is reduced.
Keytruda should only be covered to treat patients who have not received prior treatment for metastatic MSI-H/dMMR colorectal cancer and have a good performance status at the start of treatment with pembrolizumab.
Autologous Hematopoietic Cell Transplant for Patients With Multiple Sclerosis
Authors: Tran Khai , Loshak Hannah 
Published: September 2021

Evidence from 2 randomized controlled trials and 4 retrospective studies with limited methodological quality suggests that treatment with autologous hematopoietic stem cell transplantation was associated with significant improvement in clinical outcomes (e.g., disease progression, clinical relapse), MRI outcomes, the composite outcome “No Evidence of Disease Activity,” and quality of life compared to disease-modifying therapies.
Treatment with autologous hematopoietic stem cell transplantation was associated with no treatment-related mortality or life-threatening complications including progressive multifocal leukoencephalopathy. However, autologous hematopoietic stem cell transplantation was associated with expected short-term adverse events including febrile neutropenia, organ infections, sepsis, and viral reactivations; and long-term adverse events including the development of new autoimmune diseases, mainly thyroid disease.
Both identified guidelines recommend the use of autologous hematopoietic stem cell transplantation as standard of care for the treatment of highly active relapsing-remitting multiple sclerosis patients refractory to disease-modifying therapies and suggest that the treatment may be appropriate for progressive forms of multiple sclerosis with an active inflammatory component.
No cost-effectiveness studies were identified.
Chlorhexidine Gluconate for Skin Preparation During Catheter Insertion and Surgical Procedures
Authors: Tingley Kylie , Lê Mê-Linh 
Published: September 2021

There is a lack of evidence on the clinical effectiveness of chlorhexidine gluconate wipes for patients being prepped for urinary catheter insertion in acute or community care. More research in this area is needed.
In critical care settings, bathing with chlorhexidine gluconate wipes results in either a reduction or no difference in the risk of infection compared to bathing with soap and water.
The results from 1 study demonstrated that using chlorhexidine gluconate‒impregnated cloths the night before and morning of admission pre-surgery reduced infections at the site of the prosthetic in patients undergoing total joint arthroplasty when compared to standard soap and water bathing.
When reported, adverse events associated with chlorhexidine gluconate wipes included mild skin irritation.
The Portable Neuromodulation Stimulator: Targeting Neuroplasticity for Balance or Gait Deficit
Authors: Khangura Sara D. 
Published: September 2021

CADTH’s Horizon Scanning Service identifies new and emerging technologies that may be of interest to health care decision-makers in Canada
Health Technology Update articles generally focus on a single technology or intervention.
This Horizon Scan presents a brief summary of information relevant to the Portable Neuromodulation Stimulator, designed to be used in conjunction with physical therapy to improve balance or gait impairments associated with mild-to-moderate symptoms of multiple sclerosis or mild-to-moderate traumatic brain injury.
Venetoclax (Venclexta)
Authors: Reimbursement Team  
Published: September 2021

CADTH recommends that Venclexta in combination with low-dose cytarabine (LDAC) should not be reimbursed by public drug plans for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) who are 75 years or older, or who have comorbidities that preclude the use of intensive induction chemotherapy.
Evidence from 1 clinical trial demonstrated that treatment with Venclexta plus LDAC did not improve overall survival compared to treatment with LDAC alone. No conclusions could be drawn for other important outcomes including remission rates, transfusion independence, event-free survival, quality of life, and symptoms.
Patients identified a need for treatments that can maintain remission, improve quality of life and symptoms (fatigue), and that have fewer side effects. It is unclear whether Venclexta plus LDAC meets these needs.
Economic evidence suggests that Venclexta plus LDAC is not cost-effective at a willingness-to-pay threshold of $50,000 per quality-adjusted life-year (QALY), even at a 100% reduction in the price of Venclexta.
Based on public list prices, the 3-year budget impact is $70,006,541. This estimate is larger than the value identified by drug plans as feasible for adoption.
Daunorubicin and Cytarabine (Vyxeos)
Authors: Reimbursement Team  
Published: September 2021

CADTH recommends that Vyxeos should be reimbursed by public drug plans for the treatment of adults with newly diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) if certain conditions are met.
Vyxeos should only be reimbursed if the induction cycles are administered in an inpatient setting and supervised by a hematologist with expertise in managing patients with acute leukemia and if the cost of Vyxeos is reduced.
Vyxeos should only be covered to treat adult patients with newly diagnosed t-AML or AML-MRC who were deemed fit for intensive chemotherapy by the treating physician.
Shortened Drug Regimens for the Treatment of Active Tuberculosis
Authors: Brett Kendra , Severn Melissa 
Published: September 2021

For treating active tuberculosis (TB), some 4-month treatment regimens may be as effective and safe as the standard 6-month treatment regimen. However, there are also 4-month treatment regimens that seem to be less effective than the 6-month treatment regimen for treating active TB. The effectiveness of these shortened treatment regimens depends on the combination of drugs and the dose schedule.
For treating active TB, a 3-month treatment regimen appears to be less effective than the standard 6-month regimen, as it is associated with a higher rate of TB recurring within 2 years after completing treatment.
Semaglutide (Rybelsus)
Authors: Reimbursement Team  
Published: September 2021

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses semaglutide (Rybelsus), 3 mg, 7 mg, and 14 mg tablets, for oral administration
Indication: Semaglutide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2DM:

as monotherapy when metformin is considered inappropriate due to intolerance or contraindications;
in combination with other medicinal products for the treatment of diabetes.
Encorafenib in Combination With Binimetinib (Braftovi and Mektovi)
Authors: Reimbursement Team  
Published: September 2021

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses encorafenib (Braftovi), 75 mg oral capsules in combination with binimetinib (Mektovi), 15 mg oral tablets.
Indications:

Braftovi (encorafenib) is indicated, in combination with binimetinib, for the treatment of patients with unresectable metastatic melanoma with a BRAF V600 mutation, as detected by a validated test.
Mektovi (binimetinib) is indicated, in combination with encorafenib, for the treatment of patients with unresectable metastatic melanoma with a BRAF V600 mutation, as detected by a validated test.
Newer Biologics for the Treatment of Plaque Psoriasis
Authors: Subramonian Anusree , Walter Melissa 
Published: September 2021

Eight systematic reviews with network meta-analysis were identified that compared newer biologics with older biologics in patients with moderate-to-severe plaque psoriasis. There was extensive overlap of primary studies across the systematic reviews and network meta-analyses.
Newer biologics such as secukinumab, ixekizumab, brodalumab and risankizumab were more favourable compared to older biologics (adalimumab, etanercept, and ustekinumab) in reaching 90% or 100% skin clearance, as measured with the Psoriasis Area Severity Index. The risk of side effects was similar between the newer and older biologics.
KEMAMPUAN MENGANALISIS UNSUR INTRINSIK PUISI “KESABARAN’’ KARYA CHAIRIL ANWAR SISWA KELAS X SMA NEGERI 6 PINRANG KECAMATAN TIROANG KABUPATEN PINRANG
Authors: Purnamasari Dewi , M. Usman , Agussalim H. 
Published: September 2021

Penelitian ini bertujuan untuk memperoleh data dan informasi yang lengkap tentang kemampuan menganalisis unsur intrinsik puisi “Kesabaran” karya Chairil Anwar siswa kelas X SMA Negeri 6 Pinrang Kecematan Tiroang Kabupaten Pinrang. Pada tahun pelajaran 2016/2017
Populasi penelitian ini adalah siswa kelas X SMA Negeri 6 Pinrang yang berjumlah 128 siswa yang tersebar pada 4 kelas. Mencermati jumlah populasi yang cukup besar maka penarikan sampel dilakukan dengan sebesar 25% dari jumlah populasi atau sebanyak 32 siswa.
Data dikumpulkan melalui teknik dokumentasi dan teknik tes. Data tes diolah dan dianalisis dengan menggunakan teknik statistik deskriptif dengan rumus persentase (%).
Berdasarkan hasil penelitian diketahui bahwa siswa yang memperoleh nilai 75 ke atas sebanyak 28 siswa (87,5%) dan siswa yang memperoleh nilai kurang dari 75 sebanyak 4 siswa (12.5%). Dengan demikian siswa yang mendapat nlai 100 (9,375%) sebanyak 4 orang, nilai 90 (3,125%) sebanyak 1 orang, nilai 85 (21,875%) sebanyak 7 orang, nilai 80 (15,625%) sebanyak 5 orang, nilai 75 (37,5%) sebanyak 12 orang, nilai 65 (9,375%) sebanyak 3 orang dan nilai 35 (3,125%) sebanyak 1 orang
Dengan demikian dapat disimpulkan bahwa siswa kelas X SMA Negeri 6 Pinrang Kecamatan Tiroang Kabupaten Pinrang telah mampu menganalisis unsur intrinsik puisi ‘kesabaran’ karya chairil Anwar
SOSIALISASI PENYEDIAAN PROFIL DAN POTENSI DESA PADA WEBSITE UNTUK MENUNJANG EFEKTIFITAS PERENCANAAN PEMBANGUNAN DESA
Authors: Rusdi Muhammad , Hermansyah Sam 
Published: September 2021

Pada hakekatnya tujuan pembangunan suatu negara dilaksanakan untuk mensejahterakan masyarakat. Untuk mewujudkan tujuan tersebut dilaksanakan pembangunan nasional seutuhnya dan pembangunan masyarakat seluruhnya. Dalam merealisasikan tujuan pembangunan, maka segenap potensi alam harus digali, dikembangkan dan dimafaatkan sebaik-baiknya. Begitu pula dengan Potensi manusia berupa penduduk yang banyak jumlahnya harus ditingkatkan pengetahuan dan keterampilannya sehingga, mampu menggali, mengembangkan dan memanfaatkan potensi alam secara maksimal, dan pelaksanaan program pembangunan tercapai.
Penyelenggaraan pemerintahan desa Bolu Timoreng dengan memanfaatkan teknologi informasi dan komunikasi (pengelolaan Website) akan menciptakan suatu sistem informasi dan komunikasi berbasis teknologi informasi. Website dapat menjadi wahana pertanggung jawaban pemerintah desa atas penyelenggaraan pemerintahan, dan dapat diajadikan sebagai wahana penyajian profil dan potensi desa. Sehingga pemerintah dalam menyusun perencanaan pembangunan dapat tercipta perencanaan pembangunan dari pemeritah desa yang lebih baik. Website Desa merupakan wujud nyata dari implementasi pengelolaan informasi dan sarana interaksi dengan warganya, mendorong partisipasi masyarakat dan memungkinkan terjadinya transaksi, kolaborasi dan transformasi informasi dan teknologi sehingga akan mengurangi kesenjangan digital dan mendorong peningkatan partisipasi masyarakat dalam penyusunan perencanaan pembangunan.
Pendataan Potensi desa di desa Bulo Timoreng dapat dikelolah ke dalam website, sehingga dihasilkan informasi penting berbasis wilayah untuk berbagai keperluan oleh berbagai pihak yang membutuhkan terutama profil dan Potensi desa digunakan untuk menyusun perencanaan pembangunan. Dengan melihat webside potensi desa pemerintah dapat merancanakan sebuah perencanan pembagunan dengan baik dan terarah.
The Presentation of potential data for Micro, Small and Medium Enterprises (MSME) in the Food Sector at vilage office website
Authors: Salfiana Salfiana , Hermansyah Sam , Mannu Ahmad , Nurwidah Andi 
Published: September 2021

The title of this paper is the presentation of potential data for Micro, Small and Medium Enterprises (MSME) in the Food Sector at vilage office website. The purpose of this paper is the existence of MSME data in food as a source of information for development needs, especially in the food sector. The implementation method consists of preparation and briefing, data collection and data collection to the Village Website. Food MSME data presented on the Website consists of Pipang MSME profiles, the current market and the stabilization of food prices in the market. The Community Service Program 1 UMS Rappang is expected to benefit the community. By providing MSME data on this website, it is expected to be information for MSME development strategies in particular and the Environment Kampung Pisang in general.
Pembinaan Organisasi dan Pembentukan Struktur BUMDes Carawali Kecamatan Watang Pulu Kabupaten Sidrap
Authors: Lukman Lukman , Erfina Erfina 
Published: September 2021

Pada dasarnya sudah banyak sekali program pemberdayaan yang dilakukan oleh pemerintah desa Carawali. Namun sayang dalam tataran praktik berbagai penyimpangan acapkali terjadi yang disebabkan oleh beragam alasan. Misalnya alasan financial, pendidikan, dan keterampilan, kesehatan dan lain sebagainya. Badan usaha milik desa Carawali merupakan salah satu organisasi yang terkesan pakum hari ini. Tidak dapat dipungkiri peran organisasi Badan Usaha Milik Desa (BUMDes) sangat besar. Terutama untuk mengatasi permasalahan sosial masyarakat yang dapat menjadi wadah untuk melakukan pengembangan sumberdaya manusia disamping sebagai wadah pemenuhan dan pemecahan permasahalan sosial di tengah kehidupan masyarakat. Tujuan dari Kegiatan pengabdian ini adalah mengoptimalisasi pengelolaan BUMDes Carawali. Karenanya, dalam pengabdian ini penulis melakukan berbagai strategi guna mengaktifkan organisasi BUMDes Carawali yang saat ini tidak terkelola dengan baik. Adapun strategi yang dilakukan adalah melakukan pembinaan mental keorganisasian, pembinaan tata kelola administrasi, serta pembentukan struktur melalaui kegiatan workshop. Dengan demikian pengabdian ini dapat mengoptimalisasi peran BUMDes Carawali dalam penyelesaian berbagai permasalahan ditengah masyarakat. Adapun ukuran keberhasilan dari kegiatan ini adalah BUMDes Carawali dapat menjadi sehat kembali dengan terbentuknya pengurus baru yang dapat lebih berperan kemasyakat terhadap pembangunan SDM dan membantu pemerintah desa dalam memecahkan persoalan sosial yang ada. Dengan adanya BUMDes ini pemerintah desa Carawali dapat kembali mengaktifkan dana bergulirnya.
Boolean Zero Square (BZS) Semigroups
Authors: G.A. Pinto 
Published: September 2021

We introduce a new class of semigroups, that we call BZS - Boolean Zero Square-semigroups. A semigroup S with a zero element, 0, is said to be a BZS semigroup if, for every , we have or . We obtain some properties that describe the behaviour of the Green’s equivalence relations , , and . Necessary and sufficient conditions for a BZS semigroup to be a band and an inverse semigroup are obtained. A characterisation of a special type of BZS completely 0-simple semigroup is presented.
Juventudes, ruralidades y trayectorias en un escenario regional
Authors: Villegas Quispe Melissa 
Published: September 2021

Frente a las demandas de atención de las juventudes desde el bono demográfico, es importante incorporar la perspectiva de la diversidad de experiencias que viven los jóvenes a fin de comprender las oportunidades como alternativas que tienen según sus contextos. De esta manera, en el presente estudio, se describen las modalidades de las trayectorias laborales y educativas de jóvenes que cursan la educación superior técnica en un contexto territorial específico. Mediante un enfoque cualitativo centrado en las trayectorias de vida, se tuvo acceso a las vivencias de los jóvenes sobre la educación y el trabajo, y los proyectos de vida a partir de la educación superior. Considerar las particularidades de las trayectorias resulta clave para comprender a las juventudes rurales y para una mejor mirada de los territorios que configuran nuevas aspiraciones.
Faced with the demands of the youth from the demographic dividend, it's important to incorporate the perspective of the experiences' diversity that young people live to understand the opportunities that they have as alternatives according to the contexts. Thus, in this study, we describe the modalities of the laboral and educational trajectories of young people that are following Higher Technical Education in a territorial specific context. Through a qualitative approach centered in their life trajectories, there was access to their educational and laboral experiences, and their life projects in higher education. Consider their trajectories' particularities is key to a better understanding of rural youth and the territories that shape new aspirations.
ECOLOGÍA PROFUNDA EN RESPUESTA A LA CRISIS AMBIENTAL: PENSANDO EL MEDIO AMBIENTE DESDE AMÉRICA LATINA
Authors: Escalante Beltrán Soledad 
Published: September 2021

Este artículo explora las ideas de Arne Naess sobre el cambio de paradigma entre una ética antropocéntrica hacia una ética biocéntrica en el marco de una ecología profunda que contrasta con una superficial. Estudiamos algunos casos en América Latina para establecer el vínculo entre el colonialismo y la depredación ecológica, así como la deshumanización de lo indígena. Desde el punto de vista de la de-colonización, también es importante considerar la teoría crítica del pensamiento post-hegeliano, reflejada en los pensadores de la Escuela de Frankfurt. Podemos considerar que la crítica a la modernidad encaja completamente en la mentalidad del imperialismo y la colonización, y esto tiene un impacto directo en la relación entre la ecología y las sociedades que han sido despojadas de las formas de vida antiguas para ser reemplazadas por la cultura industrial de países del tercer mundo.
This article explores the idea of Arne Naess about the paradigm shift between an anthropocentric ethics towards a biocentric ethics in the frame of a Deep ecology that contrasts with a shallow one. We study some cases in Latinamerica to establish the link between colonialism and ecology depredation, as well as the de-humanization of the indigenous. In the way of a de-colonization perspective, it is also important to consider the Critical Theory of post-hegelian thought, reflected in thinkers of the Frankfurt School. We can consider that the critic to modernity fits entirely into the mentality of imperialism and colonization, and this has a direct impact into the relation between ecology and societies that have been stripped of ancient ways of life to be replaced with the industrial culture of third world countries.
Modernidad sistémica, modernidad cultural y política ecológica
Authors: Caviglia Alessandro 
Published: September 2021

El presente texto revisa las exigencias de la política ecológica a la luz de la distinción entre la modernidad sistémica y la modernidad cultural. Esto permite entender la complejidad de la modernidad y los detalles que han de tenerse en cuenta si se busca llevar a cabo una política ecológica. Ello implica precisar en qué sentido determinadas posiciones de la política ecológica resultan ser contramodernas y terminan atentando contra los derechos fundamentales.
This article revises the requirements of ecological politics in light of the distinction between systemic and cultural modernity. This allows us to understand the complexity of modernity and the details that must be taken into account if one seeks to carry out an ecological policy. Further, this implicates the need to specify in which sense certain stances of ecological politics reveal themselves as counter-modern and end up violating fundamental rights.
Presentación
Authors: Barrera Víctor Andrés 
Published: September 2021

De acuerdo con la estructura general del proceso de negociación entre el Gobierno nacional y las Farc-EP, luego de la firma del nuevo acuerdo final en diciembre de 2016 se inició la etapa de construcción de una paz estable y duradera contemplada a diez años y orientada a trabajar en los territorios más fuertemente afectados por el conflicto armado (Oficina del Alto Comisionado para la Paz, 2016, p.2). Se asume, entonces, que estamos en el momento en que debería comenzar a materializarse aquello que el alto comisionado para la paz, Sergio Jaramillo, denominó paz territorial, entendida como una apuesta para superar la lógica de fragmentación, considerada por él nuestra "enfermedad histórica".Palabras Clave: Proceso de negociacion, Gobierno nacional, Farc-EP, Paz, Alto Comisionado para la Paz, Sergio Jaramillo, Paz territorial