bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between single anterior and single posterior approaches of debridement interbody fusion and fixation for the treatment of mono-segment lumbar spine tuberculosis
Authors: Wu Hangli , Cui Yaqing , Gong Liqun , Liu Jun , Fan Yayi , Zhou Yongchun , Li Weiwei 
Published: May 2021

Abstract
Purpose
To compare the efficacy of single anterior and single posterior approach of debridement, interbody fusion, and fixation for the treatment of mono-segment lumbar spine tuberculosis (TB) patients.

Methods
Eighty-seven patients with mono-segment lumbar TB who underwent debridement, interbody fusion, and fixation through either single anterior (Group A) or single posterior approach (Group B) from January 2007 to January 2017 were enrolled in this study. The duration of the operation, blood loss, complication rate, visual analog scale (VAS), Oswestry disability index (ODI), Frankel scale, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), kyphosis angle, correction rate, correction loss, and time taken for bone graft fusion were compared between the groups.

Results
The average period of follow-up was 34.3 ± 9.5 months (24–56 months). No significant differences were observed between patients in Group A and patients in Group B in terms of gender, age, body mass index (BMI), duration of illness and preoperative evaluative indices (P > 0.05). The mean operation time and blood loss was significantly higher in Group A (P = 0.000), along with a slightly higher rate of complications compared with Group B (P = 0.848). The VAS, ODI and Frankel scale scores showed significant improvement in both groups (P = 0.000), along with the ESR, CRP and kyphosis indices (P = 0.000), which were similar in both groups at the final follow-up.

Conclusion
Both single anterior and single posterior approaches of debridement, interbody fusion and fixation are effective for mono-segment lumbar TB patients, although the single posterior approach is of a shorter duration and results in less blood loss.
The effect of clamped and unclamped umbilical cord samples on blood gas analysis
Authors: Colciago Elisabetta , Fumagalli Simona , Ciarmoli Elena , Antolini Laura , Nespoli Antonella , Mastrolia Salvatore Andrea , Tagliabue Paolo Emilio , Furlan Chiara , Manganini Cristina , Vergani Patrizia 
Published: May 2021

Abstract
Purpose
Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups.

Methods
A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped).

Results
There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group.

Conclusion
Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed.
Protective operative techniques in radical hysterectomy in early cervical carcinoma and their influence on disease-free and overall survival: a systematic review and meta-analysis of risk groups
Authors: Kampers Johanna , Gerhardt E. , Sibbertsen P. , Flock T. , Klapdor R. , Hertel H. , Jentschke M. , Hillemanns P. 
Published: May 2021

Abstract
Purpose
Radical hysterectomy with pelvic lymphadenectomy presents the standard treatment for early cervical cancer. Recently, studies have shown a superior oncological outcome for open versus minimal invasive surgery, however, the reasons remain to be speculated. This meta-analysis evaluates the outcomes of robotic and laparoscopic hysterectomy compared to open hysterectomy. Risk groups including the use of uterine manipulators or colpotomy were created.

Methods
Ovid-Medline and Embase databases were systematically searched in June 2020. No limitation in date of publication or country was made. Subgroup analyses were performed regarding the surgical approach and the endpoints OS and DFS.

Results
30 studies fulfilled the inclusion criteria. Five prospective, randomized-control trials were included. Patients were analyzed concerning the surgical approach [open surgery (AH), laparoscopic surgery (LH), robotic surgery (RH)]. Additionally, three subgroups were created from the LH group: the LH high-risk group (manipulator), intermediate-risk group (no manipulator, intracorporal colpotomy) and LH low-risk group (no manipulator, vaginal colpotomy). Regarding OS, the meta-analysis showed inferiority of LH in total over AH (0.97 [0.96; 0.98]). The OS was significantly higher in LH low risk (0.96 [0.94; 0.98) compared to LH intermediate risk (0.93 [0.91; 0.94]). OS rates were comparable in AH and LH Low-risk group. DFS was higher in the AH group compared to the LH group in general (0.92 [95%-CI 0.88; 0.95] vs. 0.87 [0.82; 0.91]), whereas the application of protective measures (no uterine manipulator in combination with vaginal colpotomy) was associated with increased DFS in laparoscopy (0.91 [0.91; 0.95]).

Conclusion
DFS and OS in laparoscopy appear to be depending on surgical technique. Protective operating techniques in laparoscopy result in improved minimal invasive survival.
Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study
Authors: Schürmann Matthias , Aljubeh Mohamed , Tiemann Carsten , Sudhoff Holger 
Published: May 2021

Abstract
Purpose
The scope of this research endeavor was the determination of the applicability of over the counter mouthwash solutions in reducing the viral load in the saliva of COVID-19 patients and hence decreasing their infectivity. Beyond that, new experimental mouthwashes were investigated in terms of a possible positive immune modulation, which might offer an additional opportunity for a positive pharmaceutical effect.

Methods
The effectivity of the mouth washing solution was determined on 34 hospitalized COVID-19 patients by measuring the viral load by RT-qPCR in pharyngeal swabs, which were taken before and after rinsing. The inflammatory modulation thru the experimental solutions was assayed in an in vitro model of virus infected nasopharyngeal epithelium cells.

Results
The clinical pilot study demonstrated that the mouth rinsing solution was able to reduce the viral load by about 90% in the saliva of most patients. This reduction was determined to persist for about 6 h. In the experimental solutions, the ingredients dexpanthenol and zinc were able to reduce the expression of proinflammatory cytokines in the cell culture model, while the antiviral response was not altered significantly.

Conclusion
We recommend the application of mouth wash solutions to COVID-19 patients, since our results indicate a reduction in infectivity and might govern the protection of health care professionals. Further improvement to the over the counter formulation can be made by utilizing zinc and dexpanthenol, as they which might be beneficial for the patients’ health.
Temporary threshold shift after noise exposure in hypobaric hypoxia at high altitude: results of the ADEMED expedition 2011
Authors: Fehrenbacher K. , Apel C. , Bertsch D. , van der Giet M. S. , van der Giet S. , Grass M. , Gschwandtl C. , Heussen N. , Hundt N. , Kühn C. , Morrison A. , Müller-Ost M. , Müller-Tarpet M. , Porath S. , Risse J. , Schmitz S. , Schöffl V. , Timmermann L. , Wernitz K. , Küpper T. 
Published: May 2021

Abstract
Objectives
To evaluate whether there is an increased risk for noise-induced hearing loss at high altitude rsp. in hypobaric hypoxia.

Methods
Thirteen volunteers got standard audiometry at 125, 250, 500, 750, 1000, 1500, 2000, 3000, 4000, 6000, and 8000 Hz before and after 10 min of white noise at 90 dB. The system was calibrated for the respective altitude. Measurements were performed at Kathmandu (1400 m) and at Gorak Shep (5300 m) (Solo Khumbu/Nepal) after 10 days of acclimatization while on trek. Temporary threshold shift (TTS) was analyzed by descriptive statistics and by factor analysis.

Results
TTS is significantly more pronounced at high altitudes. Acclimatization does not provide any protection of the inner ear, although it increases arterial oxygen saturation.

Conclusion
The thresholds beyond which noise protection is recommended (> 80 dB) or necessary (> 85 dB) are not sufficient at high altitudes. We suggest providing protective devices above an altitude of 1500 m (“ear threshold altitude”) when noise level is higher than 75 dB and using them definitively above 80 dB. This takes the individual reaction on hypobaric hypoxia at high altitude into account.
Contribution of the basal forebrain to corticocortical network interactions
Authors: Gombkoto Peter , Gielow Matthew , Varsanyi Peter , Chavez Candice , Zaborszky Laszlo 
Published: May 2021

AbstractBasal forebrain (BF) cholinergic neurons provide the cerebral cortex with acetylcholine. Despite the long-established involvement of these cells in sensory processing, attention, and memory, the mechanisms by which cholinergic signaling regulates cognitive processes remain elusive. In this study, we recorded spiking and local field potential data simultaneously from several locations in the BF, and sites in the orbitofrontal and visual cortex in transgenic ChAT-Cre rats performing a visual discrimination task. We observed distinct differences in the fine spatial distributions of gamma coherence values between specific basalo-cortical and cortico-cortical sites that shifted across task phases. Additionally, cholinergic firing induced spatial changes in cortical gamma power, and optogenetic activation of BF increased coherence between specific cortico-cortical sites, suggesting that the cholinergic system contributes to selective modulation of cortico-cortical circuits. Furthermore, the results suggest that cells in specific BF locations are dynamically recruited across behavioral epochs to coordinate interregional cortical processes underlying cognition.
Mobile-bearing versus fixed-bearing total knee arthroplasty: a meta-analysis of randomized controlled trials.
Authors: Hantouly Ashraf T. , Ahmed Abdulaziz F. , Alzobi Osama , Toubasi Ammar , Salameh Motasem , Elmhiregh Aissam , Hameed Shamsi , Ahmed Ghalib O. , Alvand Abtin , Al Dosari Mohammed Al Ateeq 
Published: May 2021

Abstract
Objective
The purpose of this study was to perform a meta-analysis comparing mobile-bearing with fixed-bearing total knee arthroplasty (TKA) in terms of all-cause revision rates, aspetic loosening, knee functional scores, range of motion and radiographic lucent lines and osteolysis.

Methods
PubMed, Cochrane Library, Google Scholar and Web of Science were searched up to January 2020. Randomized controlled trials that compared primary mobile-bearing with fixed-bearing TKA, reporting at least one of the outcomes of interest, at a minimum follow-up of 12 months were included. All outcomes of interest were pooled at short-term (< 5 years), mid-term (5 to 9 years) and long-term (> = 10 years) follow-up intervals.

Results
A total of 70 eligible articles were included in the qualitative and statistical analyses. There was no difference between mobile-bearing or fixed-bearing TKA at short-term, mid-term and long-term follow-ups in all outcome measures including all-cause revision rate, aseptic loosening, oxford knee score, knee society score, Hospital for Special Surgery score, maximum knee flexion, radiographic lucent lines and radiographic osteolysis.

Conclusion
The current level of evidence demonstrated that both mobile-bearing and fixed-bearing designs achieved excellent outcomes, yet it does not prove the theoretical advantages of the mobile-bearing insert over its fixed-bearing counterpart. The use of either design could therefore be supported based on the outcomes assessed in this study.
Level of Evidence: Level II, Therapeutic
Bidirectional relationship of problematic Internet use with hyperactivity/inattention and depressive symptoms in adolescents: a population-based cohort study
Authors: Morita Masaya , Ando Shuntaro , Kiyono Tomoki , Morishima Ryo , Yagi Tomoko , Kanata Sho , Fujikawa Shinya , Yamasaki Syudo , Nishida Atsushi , Kasai Kiyoto 
Published: May 2021

AbstractProblematic Internet use (PIU), hyperactivity/inattention, and depressive symptoms are comorbid problems in adolescence, but the causal relationships among these issues are unclear. To assess the relationships among PIU, hyperactivity/inattention, and depressive symptoms in adolescents in the general population. This longitudinal cohort study used data from the Tokyo Teen Cohort study in Tokyo, Japan, for two years between October 2012 and January 2015. Of the 3171 pairs of children and parents, 3007 pairs continued to participate in the second wave of the Tokyo Teen Cohort study. A total of 3007 children were included in the analysis (mean [standard deviation] age, 9.7 [0.4] years; 1418 women [47.2%]. Cross-lagged panel analysis revealed that PIU at timepoint 1 was significantly associated with hyperactivity/inattention at timepoint 2 (β = 0.03; 95% confidence interval (CI) 0.01–0.06), and hyperactivity/inattention at timepoint 1 was also significantly associated with PIU at timepoint 2 (β = 0.07; 95% CI 0.04–0.10), even after adjustments were made for depressive symptoms. Furthermore, PIU at timepoint 1 was significantly associated with depressive symptoms at timepoint 2 (β = 0.05; 95% CI 0.01–0.12), and depressive symptoms at timepoint 1 were also significantly associated with PIU at timepoint 2 (β = 0.05; 95% CI 0.02–0.07), even after adjustments were made for hyperactivity/inattention. These results support the bidirectional relationships among PIU, hyperactivity/inattention, and depressive symptoms. PIU may be a target to improve hyperactivity/inattention and depressive symptoms in adolescents.
Do households prefer to move up or down the urban hierarchy during an economic crisis?
Authors: van Leeuwen Eveline S. , Venhorst Viktor A. 
Published: May 2021

AbstractIn this paper, we investigate the relationship between adverse economic circumstances and the desire of Dutch households to move up or down the urban hierarchy. We apply three consecutive waves of the Dutch Housing Demand Survey (WoON) in a repeated cross-section setting, with data collected at the time of the Global Financial Crisis (GFC) and its aftermath. We find that households desire to move down the urban hierarchy during the volatile and uncertain periods following the GFC. This is a surprising result, given that urban areas are generally considered more opportunity rich. In order to uncover the mechanisms driving this result, we considered the impact of the economic circumstances on the general willingness to move and on the underlying motives. We find that willingness to move increased when the adverse economic consequences of the GFC hit Dutch households. Further, it appears that this willingness to move is only partially related to work. Besides work, desires to move for health, education, vicinity to family and friends, and reasons related to the dwelling, also become more prevalent during the aftermath of the GFC as well. This heterogeneity in impacts and consequences for household desired mobility serves to explain some of the mixed results in the literature, and generates lessons for current and future crises such as the Covid-19 pandemic.
Design of a high-stability heterogeneous clock system for small satellites in LEO
Authors: Van Buren Damon , Axelrad Penina , Palo Scott 
Published: May 2021

AbstractWe describe our investigation into the performance of low-power heterogeneous timing systems for small satellites, using real GPS observables from the GRACE Follow-On mission. Small satellites have become capable platforms for a wide range of commercial, scientific and defense missions, but they are still unable to meet the needs of missions that require precise timing, on the order of a few nanoseconds. Improved low-power onboard clocks would make small satellites a viable option for even more missions, enabling radio aperture interferometry, improved radio occultation measurements, high altitude GPS navigation, and GPS augmentation missions, among others. One approach for providing improved small satellite timekeeping is to combine a heterogeneous group of oscillators, each of which provides the best stability over a different time frame. A hardware architecture that uses a single-crystal oscillator, one or more Chip Scale Atomic Clocks (CSACs) and the reference time from a GPS receiver is presented. The clocks each contribute stability over a subset of timeframes, resulting in excellent overall system stability for timeframes ranging from less than a second to several days. A Kalman filter is used to estimate the long-term errors of the CSACs based on the CSAC-GPS time difference, and the improved CSAC time is used to discipline the crystal oscillator, which provides the high-stability reference clock for the small satellite. Simulations using GRACE-FO observations show time error standard deviations for the system range from 2.3 ns down to 1.3 ns for the clock system, depending on how many CSACs are used. The results provide insight into the timing performance which could be achieved on small LEO spacecraft by a low power timing system.
The impact of the Beirut blast on the COVID-19 situation in Lebanon
Authors: Fares Mohamad Y. , Musharrafieh Umayya , Bizri Abdul Rahman 
Published: May 2021

Abstract
Aim
On August 4, 2020, a massive explosion hit Lebanon’s capital city, Beirut. The aim of this study was to explore the effect of the Beirut blast on the COVID-19 situation in the country.

Subject and Methods
Data on COVID-19 were retrieved from the Lebanese Ministry of Public Health (LMOPH), where all the COVID-19 positive cases were reported. The study was divided into two periods, considering the incubation period of the COVID-19 virus: (July 27–August 9, 2020) and (August 10–23, 2020). Information obtained included daily number of cases, tests, deaths, hospitalized patients, intensive care unit (ICU) patients, and mode of acquisition (local vs. expat). Daily positivity rates were reported per 100 tests. An independent sample t-test and a Joinpoint regression analysis were used to determine significance. A p value less than 0.05 was considered significant.

Results
A total of 201,010 tests were conducted during our studied period, with 8993 positive cases, constituting a total positivity rate of 4.5 per 100 tests. Case fatality rate over the studied period was 0.8%. The positivity rate of the period prior to August 10, 2020, was 2.7 per 100 tests, significantly less than that of the period following the explosion, which was 6.4 per 100 tests (p < 0.001). During our studied period, daily positivity rates were significantly increasing at a slope of 0.29 (p < 0.001). A significant increase in slope was noted on August 13, 2020 (p < 0.001). The number of hospitalized patients increased from 139 patients on July 27 to 266 on August 23, 2020, and that of ICU patients increased from 36 to 75.

Conclusion
The port of Beirut explosion resulted in a significant increase in the daily number of positive COVID-19 cases. The aftermath of the explosion, the damage to healthcare facilities, and the overcrowding due to emergency efforts were contributing factors to that increase.
Seismic hazard for the Trans Adriatic Pipeline (TAP). Part 2: broadband scenarios at the Fier Compressor Station (Albania)
Authors: Moratto L. , Vuan A. , Saraò A. , Slejko D. , Papazachos C. , Caputo R. , Civile D. , Volpi V. , Ceramicola S. , Chatzipetros A. , Daja S. , Fabris P. , Garcia-Pelaez J. , Geletti R. , Karvelis P. , Pavlides S. , Rapti D. , Rebez A. , Rossi G. , Sandron D. , Santulin M. , Sboras S. , Tamaro A. , Zecchin M. , Zgur F. , Zuliani D. 
Published: May 2021

AbstractTo ensure environmental and public safety, critical facilities require rigorous seismic hazard analysis to define seismic input for their design. We consider the case of the Trans Adriatic Pipeline (TAP), which is a pipeline that transports natural gas from the Caspian Sea to southern Italy, crossing active faults and areas characterized by high seismicity levels. For this pipeline, we develop a Probabilistic Seismic Hazard Assessment (PSHA) for the broader area, and, for the selected critical sites, we perform deterministic seismic hazard assessment (DSHA), by calculating shaking scenarios that account for the physics of the source, propagation, and site effects. This paper presents a DSHA for a compressor station located at Fier, along the Albanian coastal region. Considering the location of the most hazardous faults in the study site, revealed by the PSHA disaggregation, we model the ground motion for two different scenarios to simulate the worst-case scenario for this compressor station. We compute broadband waveforms for receivers on soft soils by applying specific transfer functions estimated from the available geotechnical data for the Fier area. The simulations reproduce the variability observed in the ground motion recorded in the near-earthquake source. The vertical ground motion is strong for receivers placed above the rupture areas and should not be ignored in seismic designs; furthermore, our vertical simulations reproduce the displacement and the static offset of the ground motion highlighted in recent studies. This observation confirms the importance of the DSHA analysis in defining the expected pipeline damage functions and permanent soil deformations.
The circular economy potential of urban organic waste streams in low- and middle-income countries
Authors: Ddiba Daniel , Andersson Kim , Rosemarin Arno , Schulte-Herbrüggen Helfrid , Dickin Sarah 
Published: May 2021

AbstractThere is growing recognition of the potential environmental and socio-economic benefits of applying a circular approach to urban organic waste management through resource recovery. Decisions around planning and implementing circular urban waste systems require estimates of the quantity of resources available in waste streams and their potential market value. However, studies assessing circular economy potential have so-far been conducted mostly in high-income countries, yet cities in low- and middle-income countries have different challenges when developing a circular economy. This paper addresses this gap by estimating the resource recovery potential of organic waste streams in the context of low- and middle-income countries, illustrated with the case of Kampala, Uganda. A simplified material flow analysis approach is used to track the transformation of waste streams, namely faecal sludge, sewage sludge and organic solid waste into the resource recovery products biogas, solid fuel, black soldier fly larvae and compost. Findings indicate that even at current rates of waste collection, the three waste streams combined could annually yield 135,000 tonnes of solid fuel or 39.6 million Nm3 of biogas or 15,000 tonnes of black soldier fly larvae or 108,000 tonnes of compost and revenues from the products could range from 5.1 million USD from compost to 47 million USD from biogas. The results demonstrate how complex information describing urban waste can be presented to facilitate decision making and planning by stakeholders. By highlighting different resource recovery opportunities, application of this approach could provide an incentive for more sustainable urban sanitation and waste management systems.