bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Observation of Outcomes and Patient Access to Integrated Care Following Point-of-Care Glycemic Screening in Community Health Center Dental Safety Net Clinics
Authors: Glurich Ingrid , Berg Richard , Panny Aloksagar , Shimpi Neel , Steinmetz Annie , Nycz Greg , Acharya Amit 
Published: May 2021

Introduction: Rates of diabetes/prediabetes continue to increase, with disparity populations disproportionately affected. Previous field trials promoted point-of-care (POC) glycemic screening in dental settings as an additional primary care setting to identify potentially at-risk individuals requiring integrated care intervention. The present study observed outcomes of POC hemoglobin A1c (HbA1c) screening at community health center (CHC) dental clinics (DC) and compliance with longitudinal integrated care management among at-risk patients attending dental appointments.Materials and Methods: POC HbA1c screening utilizing Food and Drug Administration (FDA)-approved instrumentation in DC settings and periodontal evaluation of at-risk dental patients with no prior diagnosis of diabetes/prediabetes and no glycemic testing in the preceding 6 months were undertaken. Screening of patients attending dental appointments from October 24, 2017, through September 24, 2018, was implemented at four Wisconsin CHC-DCs serving populations with a high representation of disparity. Subjects meeting at-risk profiles underwent POC HbA1c screening. Individuals with measures in the diabetic/prediabetic ranges were advised to seek further medical evaluation and were re-contacted after 3 months to document compliance. Longitudinal capture of glycemic measures in electronic health records for up to 2 years was undertaken for a subset (n = 44) of subjects with available clinical, medical, and dental data. Longitudinal glycemic status and frequency of medical and dental access for follow-up care were monitored.Results: Risk assessment identified 224/915 (24.5%) patients who met inclusion criteria following two levels of risk screening, with 127/224 (57%) qualifying for POC HbA1c screening. Among those tested, 62/127 (49%) exhibited hyperglycemic measures: 55 in the prediabetic range and seven in the diabetic range. Moderate-to-severe periodontitis was more prevalent in patients with prediabetes/diabetes than in individuals with measures in the normal range. Participant follow-up compliance at 3 months was 90%. Longitudinal follow-up documented high rates of consistent access (100 and 89%, respectively), to the integrated medical/DC environment over 24 months for individuals with hyperglycemic screening measures.Conclusion: POC glycemic screening revealed elevated HbA1c measures in nearly half of at-risk CHC-DC patients. Strong compliance with integrated medical/dental management over a 24-month interval was observed, documenting good patient receptivity to POC screening in the dental setting and compliance with integrated care follow-up by at-risk patients.
Sport Concussion Assessment Tool-5th Edition (SCAT5): Normative Reference Values for the National Rugby League Women's Premiership
Authors: Iverson Grant L. , Howell David R. , Van Patten Ryan , Bloomfield Paul , Gardner Andrew J. 
Published: May 2021

Objective: To establish normative reference values for the Sport Concussion Assessment Tool-5th Edition (SCAT5) for the new National Rugby League Women's Premiership.Methods: Preseason SCAT5 baseline testing was administered individually to all National Rugby League Women's Premiership players (N = 117). Testing was completed by the medical staff. Normative reference values were calculated for the components of the SCAT5, including the Standardized Assessment of Concussion, modified Balance Error Scoring System, and the Symptom Scale. A small case series of players who sustained concussions were included to illustrate the use of the new normative data.Results: The median Standardized Assessment of Concussion total score was 27.0 (M = 26.9, SD = 2.1). The median modified Balance Error Scoring System score was 2.0 (M = 2.4, SD = 2.2). The median number of symptoms score was 1.0 (M = 3.2, SD = 4.7) and the median symptom severity score was 2.0 (M = 5.4, SD = 8.2). The most common baseline symptom was fatigue or low energy (33%), followed by trouble sleeping (24%), headache (23%), neck pain (22%), and difficulty remembering (21%). In the total sample, 41% reported no symptoms. The clinical interpretation of these new normative data to a case series of women with concussions is provided.Conclusions: Normative reference values are provided for the SCAT5 for women who are professional rugby league players. Using these normative data will improve clinical interpretation of SCAT5 scores following a concussion.
Metabolism and Tissue Distribution of Chelerythrine and Effects of Macleaya Cordata Extracts on Liver NAD(P)H Quinone Oxidoreductase
Authors: Huang Chong-Yin , Huang Ya-Jun , Zhang Zhuo-Yi , Liu Yi-Song , Liu Zhao-Ying 
Published: May 2021

Background:Macleaya cordata (Willd.) (Papaveraceae) is listed as a feed additive in animal production by the European Food Authority.Methods: The metabolites of chelerythrine in rats were measured in vitro and in vivo by rapid and accurate high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (HPLC/QqTOF-MS). The structures of CHE metabolites were elucidated by comparing their changes in accurate molecular masses and fragment ions with those of parent ion or metabolite. The metabolic enzymes that were involved in chelerythrine reduction were investigated using an inhibition method. The tissue distribution of chelerythrine and the effects on NQO1 following intragastric administration with M. cordata extracts in rats were examined.Results: A total of twelve metabolites of chelerythrine were characterized by this approach in rat liver S9 and in vivo. The reduction of the iminium bond of chelerythrine and subsequent O-demethylation was the main metabolic pathway of chelerythrine in rat liver S9 while the reduction of the iminium bond of chelerythrine was the main metabolic pathway of chelerythrine in rats in vivo. After the rats were given intragastric administration, the low concentration residues of sanguinarine and chelerythrine in different rat tissues were found at 48 h after the last dose, suggesting that both compounds could be widely distributed in tissues. The results also indicated that XO, NQO1, NQO2, and carbonyl reductase are involved in chelerythrine reduction. Macleaya cordata extracts treated female and male rats, respectively, showed different responses, inhibiting NQO1 activity in males, but inducing NQO1 activity in females. Chelerythrine had a weak impact on NQO1 activity, but sanguinarine inhibited NQO1 activityConclusion: Through studying the effects of cytosolic reductase inhibitors on chelerythrine reduction and the impact of chelerythrine and sanguinarine on the activity of NQO1 in vitro and in vivo, we clarified the potential drug interaction of Macleaya cordata extract in clinical application, so as to provide theoretical guidance for clinically safe medication. In addition, it provided a reference basis for the metabolic mechanism of chelerythrinein rats.
Effects of Synbiotics on the Fecal Microbiome and Metabolomic Profiles of Healthy Research Dogs Administered Antibiotics: A Randomized, Controlled Trial
Authors: Whittemore Jacqueline C. , Price Joshua M. , Moyers Tamberlyn , Suchodolski Jan S. 
Published: May 2021

Background: Antibiotic-associated gastrointestinal signs occurred in 100% of dogs administered enrofloxacin with metronidazole in a previous study, and signs partially were mitigated by synbiotics. The objective of this randomized, double-blinded, placebo-controlled trial was to compare the fecal microbiome and metabolome of dogs administered enrofloxacin and metronidazole, followed by either a placebo or a bacterial/yeast synbiotic combination.Methods: Twenty-two healthy research dogs were randomized to two treatment groups. There were three study periods: baseline, treatment, and washout. Dogs were administered enrofloxacin (10 mg/kg qd) and metronidazole (12.5 mg/kg BID), followed 1 h later by placebo or a commercially-available synbiotic combination (BID), per os for 21 days with reevaluation 56 days thereafter. Fecal samples were collected on days 5–7 (baseline), 26–28, and 82–84. The fecal microbiome was analyzed by qPCR and sequencing of 16S rRNA genes; time-of-flight mass spectrometry was used to determine metabolomic profiles. Split plot repeated measures mixed model ANOVA was used to compare results between treatment groups. P &lt; 0.05 was considered significant, with Benjamini and Hochberg's False Discovery Rate used to adjust for multiple comparisons.Results: Alpha diversity metrics differed significantly over time in both treatment groups, with incomplete recovery by days 82–84. Beta diversity and the dysbiosis index differed significantly over time and between treatment groups, with incomplete recovery at days 82–84 for dogs in the placebo group. Significant group-by-time interactions were noted for 15 genera, including Adlercreutzia, Bifidobacterium, Slackia, Turicibacter, Clostridium (including C. hiranonis) [Ruminococcus], Erysipelotrichaceae_g_, [Eubacterium], and Succinivibrionaceae_g_. Concurrent group and time effects were present for six genera, including Collinsella, Ruminococcaceae_g_, and Prevotella. Metabolite profiles differed significantly by group-by-time, group, and time for 28, 20, and 192 metabolites, respectively. These included short-chain fatty acid, bile acid, tryptophan, sphingolipid, benzoic acid, and cinnaminic acid metabolites, as well as fucose and ethanolamine. Changes in many taxa and metabolites persisted through days 82–84.Conclusion: Antibiotic administration causes sustained dysbiosis and dysmetabolism in dogs. Significant group-by-time interactions were noted for a number of taxa and metabolites, potentially contributing to decreased antibiotic-induced gastrointestinal effects in dogs administered synbiotics.
Biochemical and Initial Structural Characterization of the Monocot Chimeric Jacalin OsJAC1
Authors: Huwa Nikolai , Weiergräber Oliver H. , Kirsch Christian , Schaffrath Ulrich , Classen Thomas 
Published: May 2021

The monocot chimeric jacalin OsJAC1 from Oryza sativa consists of a dirigent and a jacalin-related lectin domain. The corresponding gene is expressed in response to different abiotic and biotic stimuli. However, there is a lack of knowledge about the basic function of the individual domains and their contribution to the physiological role of the entire protein. In this study, we have established a heterologous expression in Escherichia coli with high yields for the full-length protein OsJAC1 as well as its individual domains. Our findings showed that the secondary structure of both domains is dominated by β-strand elements. Under reducing conditions, the native protein displayed clearly visible transition points of thermal unfolding at 59 and 85 °C, which could be attributed to the lectin and the dirigent domain, respectively. Our study identified a single carbohydrate-binding site for each domain with different specificities towards mannose and glucose (jacalin domain), and galactose moieties (dirigent domain), respectively. The recognition of different carbohydrates might explain the ability of OsJAC1 to respond to different abiotic and biotic factors. This is the first report of specific carbohydrate-binding activity of a DIR domain, shedding new light on its function in the context of this monocot chimeric jacalin.
Detection of Zoonotic Cryptosporidium ubiquitum in Alpine Wild Ruminants
Authors: Trogu Tiziana , Formenti Nicoletta , Marangi Marianna , Viganò Roberto , Bionda Radames , Giangaspero Annunziata , Lanfranchi Paolo , Ferrari Nicola 
Published: May 2021

Cryptosporidium is a widespread apicomplexan protozoan of major zoonotic importance, characterized by a wide host range, and with relevant economic implications and potential negative effects on livestock and wildlife population dynamics. Considering the recent strong demographic increase of alpine ungulates, in this study, carried out in the Italian Northwestern Alps, we investigated the occurrence of Cryptosporidium spp. in these species and their potential involvement in environmental contamination with Cryptosporidium spp. oocysts. The immune-enzymatic approach revealed a Cryptosporidium prevalence of 1.7% (5/293), 0.5% (1/196) and 3.4% (4/119) in alpine chamois (Rupicapra rupicapra), red deer (Cervus elaphus) and roe deer (Capreolus capreolus), respectively. Positive samples were subjected to polymerase chain reaction (PCR) amplification for the COWP and gp60 genes. The presence of Cryptosporidium was confirmed in one chamois and four roe deer. Sequences obtained clustered within Cryptosporidium ubiquitum, currently recognized as an emerging zoonotic species. This finding represents the first detection of zoonotic C. ubiquitum in chamois and in the Alpine environment. Despite the low observed prevalences, environmental contamination by oocysts could play a role as a potential source of infections for humans and livestock.
Influence of Selective Agents (EMJH-STAFF), Sample Filtration and pH on Leptospira interrogans Serovar Icterohaemorrhagiae Cultivation and Isolation from Swine Urine
Authors: Steinparzer Romana , Mair Tamara , Unterweger Christine , Steinrigl Adi , Schmoll Friedrich 
Published: May 2021

Leptospira spp. cause the zoonotic disease leptospirosis, which occurs in numerous mammalians worldwide. Isolation is still important for serotyping and genotyping of Leptospira, which in turn is essential for epidemiological surveillance of leptospirosis and the development of diagnostic tests and vaccines. However, isolation of Leptospira from clinical specimens is inherently insensitive. This study was conducted to examine the influence of selective agents, sample filtration, sample pH and the use of phosphate buffered saline (PBS) buffer for sample storage to improve the success of cultivation and isolation of Leptospira interrogans serovar Icterohaemorrhagiae from swine urine. EMJH (Ellinghausen McCullough, Johnson and Harris) medium including the selective agents sulfamethoxazole, trimethoprim, amphotericin, fosfomycin and 5-fluorouracil (STAFF) increased the success of Leptospira isolation from spiked swine urine samples. Sample filtration yielded only negative results. Isolation in EMJH-STAFF was successful from swine urine with a density as low as 104 Leptospira/mL, and urine with pH ≤ 7 impaired the cultivation rate. Cultivation and isolation were not improved by the addition of PBS to spiked urine samples prior to storage for 24 h at 4 °C. The results of the study demonstrate that cultivation and isolation of leptospires from swine urine can be improved by enhanced methods.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI STUNTING PADA BALITA DI KOTA GORONTALO MENGGUNAKAN REGRESI BINOMIAL NEGATIF
Authors: ZUBEDI FAHREZAL , ALIU MUFTIH ALWI , RAHIM YOLANDA , OROH FRANKY ALFRITS 
Published: May 2021

This study aims to model stunting cases in children under five in Gorontalo city in 2018. In this model, it can be seen that the significant factors that affect stunting cases in children under five in Gorontalo city in 2018. This study uses data on stunting cases in 9 (nine) districts in the city of Gorontalo and the factors that influence it. The research data were obtained from the Public Health in Gorontalo city. This study used one response variable, namely the number of cases of stunting and four predictor variables, namely number of toddlers who received exclusive breastfeeding, the percentage of low birth weight (LBW), the percentage toddlers who received complete basic immunization, and number of proper sanitation. The results obtained were the variables of number of toddlers who received exclusive breastfeeding and the percentage toddlers who received complete basic immunization which had a significant effect on stunting cases in children under five in the city of Gorontalo in 2018. This was indicated by the P-value of the variable for number of toddlers who received exclusive breastfeeding of 0.00283 and P-value of variable the percentage toddlers who get complete basic immunization is 0.06564.
PROSPECTS FOR THE USE OF TRICHLOROETHYL AMIDES WITH THIOAMIDE FUNCTIONS IN THE TECHNOLOGY OF BRILLIANT NICKEL PLATING
Authors: Shurupov Dmitriy , Andreeva Yuliya , Balyueva Yuliya , Sosnovskaya Nina , Rozencveyg Igor' 
Published: May 2021

The influence of organic additives in the nickel-plating sulfate electrolyte on the pos sibility of obtaining shiny coatings is investigated. The presence in the structure of the additive of
trichloramide fragments and substituents containing a thiocarbonyl group-a residue of thiourea or
rubeanoic acid, allows to obtain shiny nickel coatings without the introduction of additional reagents.
DEVELOPMENT OF A PROGRAM FOR CALCULATING THE CONCENTRATION FIELD OF THE DISTRIBUTION OF SULFUR DIOXIDE IN THE AIR
Authors: Blaschinskaya Oksana , Kobozev Vladimir , Patrushev Konstantin 
Published: May 2021

A program for calculating the concentration field of the distribution of sulfur dioxide
in the air from a point source of emission using a kinetic model, taking into account the barrier surface
of green spaces, is considered.
ARTIFICIAL INTELLIGENCE IN POWER INDUSTRY
Authors: Konovalov Yuriy , Vaygachev Anton 
Published: May 2021

Trends in the development of artificial intelligence and the use of neural networks as
applied to the power industry are considered. It is revealed that the well-known forecasting systems
based on artificial neural networks are difficult to formalize and get an unambiguous solution. There fore, this problem must be solved using a systematic approach that combines the capabilities of artifi cial neural networks and fuzzy logic under conditions of partial uncertainty of parameters
SIMULATION OF EMERGENCY MODES OF POWER SUPPLY SYSTEMS OF NON-TRACTION CONSUMERS
Authors: Lyubchenko Irina 
Published: May 2021

The influence of sources of reactive power on the quality of electricity on the tires of
non-traction consumers who receive power from the two-wire-rail line in the event of a short circuit in
the contact network is studied. The results show that the use of sources of reactive power contributes
to the maintenance of voltage on the substation tires, significantly reducing the coefficient of
asymmetry in the reverse sequence.
ELECTROMAGNETIC SAFETY AT THE INTERSECTION OF TRACTION NETWORKS AND POWER LINES WHEN WORKING AT HEIGHT
Authors: Seredkin Dmitriy 
Published: May 2021

The electromagnetic fields affecting the personnel during the maintenance of the
traction network from the leiter are considered. The results obtained during calculations using the
methodology developed at IrGUPS and implemented in the Fazonord software package show that the
electric and magnetic field strengths exceed the permissible levels for electrical personnel
LABOR PROTECTION IN THE CHILD CARE CENTER
Authors: Krasnova Anzhela , Glavinskaya Lyubov' 
Published: May 2021

The article is devoted to the study of the work of a specialist in labor protection of
the Center for Assistance to children. The article analyzes the implementation of the work on the crea tion of an integrated system of protection of life, health, safety, fire safety, labor protect
BIS(2-CHLOROPROPENYL)SULFIDE HETEROCYCLIZATION UNDER THE ACTION OF CHALCOGENS IN HYDRAZINE HYDRATE–KOH
Authors: Manuylov Viktor , Nikonova Valentina , Rozencveyg Igor' , Korchevin Nikolay 
Published: May 2021

The sense of bis(2-chloropropenyl)sulfide heterocyclization at its interaction with
sulfur, selen and tellur in the hydrazine hydrate–KOH system has been studied. The suggest plausible
mechanism of different heterocycles formation is discussed.
ISOTHIURONIUM SALTS CONTAINING OXYGEN OR NITROGEN ATOMS IN AN ORGANIC FRAGMENT – A NEW TYPE OF GLOSS-FORMING AGENTS IN ELECTROCHEMICAL NICKEL PLATING
Authors: Preina Anastasiya , Dmitrieva Valeriya , Grabel'nyh Valentina , Sosnovskaya Nina 
Published: May 2021

Based on chlorex, bis (2-chloroethyl) disubstituted isothiuronium salts containing
additional oxygen or nitrogen atoms have been synthesized for amine and thiourea. The resulting salts
were studied as gloss-forming additives in the Watts electrolyte for the electrochemical production of
shiny nickel coatings. The electrolysis modes that ensure the production of high-quality coatings are
found.
Observations of Gravity Waves in the Middle Atmosphere of Mars
Authors: Saunders William R. , Person Michael J. , Withers Paul 
Published: May 2021

Abstract
Gravity waves are ubiquitous throughout the atmosphere of Mars. Their propagation and dissipation influence the circulation and thermal structure of the middle and upper atmosphere. Yet there have been few studies of gravity wave characteristics in the middle atmosphere, a region that is critical for their propagation from generation in the lower atmosphere to dissipation and associated exchanges of momentum and energy in the upper atmosphere. There have been few studies because few atmospheric profiles span the middle atmosphere with the kilometer-scale or smaller vertical resolution that is Required to characterize gravity waves. Here we report the characterization of gravity waves in the middle atmosphere using 12 high-resolution atmospheric density profiles. Four of these were acquired from a ground-based stellar occultation from 1976 that yielded immersion and emersion profiles on opposite sides of the planet, and the remaining eight were measured during atmospheric entry by landers and rovers. Predominant wavelengths were 3–14 km, and amplitudes were generally 0.8%–2.5%. Where static stability is large and positive, gravity waves grow efficiently. In other instances, static stability is not large and positive over a wide altitude range, and gravity wave amplitudes do not behave as neatly. These observations of gravity waves in the middle atmosphere of Mars can be used to test gravity wave parameterizations in large-scale general circulation models and to investigate predictions for how gravity wave propagation and dissipation influence the circulation and thermal structure of the middle and upper atmosphere.
Fe xii and Fe xiii Line Widths in the Polar Off-limb Solar Corona up to 1.5 R
⊙
Authors: Zhu 朱 Yingjie 英杰 , Szente Judit , Landi Enrico 
Published: May 2021

Abstract
The nonthermal broadening of spectral lines formed in the solar corona is often used to seek evidence of Alfvén waves propagating in the corona. To have a better understanding of the variation of line widths at different altitudes, we measured the line widths of the strong Fe xii 192.4, 193.5, and 195.1 Å and Fe xiii 202.0 Å in an off-limb southern coronal hole up to 1.5 R
⊙ observed by the Extreme Ultraviolet Spectrometer on board the Hinode satellite. We compared our measurements to the predictions from the Alfvén Wave Solar Model (AWSoM) and the SPECTRUM module. We found that the Fe xii and Fe xiii line widths first increase monotonically below 1.1 R
⊙ and then keep fluctuating between 1.1 and 1.5 R
⊙. The synthetic line widths of Fe xii and Fe xiii below 1.3 R
⊙ are notably lower than the observed ones. We found that the emission from a streamer in the line of sight significantly contaminates the coronal hole line profiles even up to 1.5 R
⊙ both in observations and simulations. We suggest that either the discrepancy between the observations and simulations is caused by insufficient nonthermal broadening at the streamer in the AWSoM simulation or the observations are less affected by the streamer. Our results emphasize the importance of identifying the origin of the coronal EUV emission in off-limb observations.