bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-fire movements of Pacific marten (Martes caurina) depend on the severity of landscape change
Authors: Volkmann Logan A. , Hodges Karen E. 
Published: October 2021

AbstractBackgroundWildfires and forestry activities such as post-fire salvage logging are altering North American forests on a massive scale. Habitat change and fragmentation on forested landscapes may threaten forest specialists, such as Pacific marten (Martes caurina), that require closed, connected, and highly structured habitats. Although marten use burned landscapes, it is unclear how these animals respond to differing burn severities, or how well they tolerate additional landscape change from salvage logging.MethodsWe used snow tracking and GPS collars to examine marten movements in three large burns in north-central Washington, USA (burned in 2006) and central British Columbia, Canada (burned in 2010 and 2017). We also assessed marten habitat use in relation to areas salvage-logged in the 2010 burn. We evaluated marten path characteristics in relation to post-fire habitat quality, including shifts in behaviour when crossing severely-disturbed habitats. Using GPS locations, we investigated marten home range characteristics and habitat selection in relation to forest cover, burn severity, and salvage logging.ResultsMarten in the 2006 burn shifted from random to directed movement in areas burned at high severity; in BC, they chose highly straight paths when crossing salvage-blocks and meadows. Collared marten structured their home ranges around forest cover and burn severity, avoiding sparsely-covered habitats and selecting areas burned at low severity. Marten selected areas farther from roads in both Washington and BC, selected areas closer to water in the 2006 burn, and strongly avoided salvage-logged areas of the 2010 burn. Marten home ranges overlapped extensively, including two males tracked concurrently in the 2010 burn.ConclusionsAreas burned at low severity provide critical habitat for marten post-fire. Encouragingly, our results indicate that both male and female marten can maintain home ranges in large burns and use a wide range of post-fire conditions. However, salvage-logged areas are not suitable for marten and may represent significant barriers to foraging and dispersal.
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus
Authors: Jayaraman Anusha , Htike Thein Than , James Rachel , Picon Carmen , Reynolds Richard 
Published: October 2021

AbstractThe pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer’s disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal damage. The tumor necrosis factor (TNF) superfamily of cytokines are involved in many systemic chronic inflammatory and degenerative conditions and are amongst the key mediators of neuroinflammation. TNF binds to the TNFR1 and TNFR2 receptors to activate diverse cellular responses that can be either neuroprotective or neurodegenerative. In particular, TNF can induce programmed necrosis or necroptosis in an inflammatory environment. Although activation of necroptosis has recently been demonstrated in the AD brain, its significance in AD neuron loss and the role of TNF signaling is unclear. We demonstrate an increase in expression of multiple proteins in the TNF/TNF receptor-1-mediated necroptosis pathway in the AD post-mortem brain, as indicated by the phosphorylation of RIPK3 and MLKL, predominantly observed in the CA1 pyramidal neurons. The density of phosphoRIPK3 + and phosphoMLKL + neurons correlated inversely with total neuron density and showed significant sexual dimorphism within the AD cohort. In addition, apoptotic signaling was not significantly activated in the AD brain compared to the control brain. Exposure of human iPSC-derived glutamatergic neurons to TNF increased necroptotic cell death when apoptosis was inhibited, which was significantly reversed by small molecule inhibitors of RIPK1, RIPK3, and MLKL. In the post-mortem AD brain and in human iPSC neurons, in response to TNF, we show evidence of altered expression of proteins of the ESCRT III complex, which has been recently suggested as an antagonist of necroptosis and a possible mechanism by which cells can survive after necroptosis has been triggered. Taken together, our results suggest that neuronal loss in AD is due to TNF-mediated necroptosis rather than apoptosis, which is amenable to therapeutic intervention at several points in the signaling pathway.
Examining emotion regulation in binge-eating disorder
Authors: Walenda Anna , Kostecka Barbara , Santangelo Philip S. , Kucharska Katarzyna 
Published: October 2021

Abstract
Background
Inefficient mechanisms of emotional regulation appear essential in understanding the development and maintenance of binge-eating disorder (BED). Previous research focused mainly on a very limited emotion regulation strategies in BED, such as rumination, suppression, and positive reappraisal. Therefore, the aim of the study was to assess a wider range of emotional regulation strategies (i.e. acceptance, refocusing on planning, positive refocusing, positive reappraisal, putting into perspective, self-blame, other-blame, rumination, and catastrophizing), as well as associations between those strategies and binge-eating-related beliefs (negative, positive, and permissive), and clinical variables (eating disorders symptoms, both anxiety, depressive symptoms, and alexithymia).

Methods
Women diagnosed with BED (n = 35) according to the DSM-5 criteria and healthy women (n = 41) aged 22–60 years were assessed using: the Eating Attitudes Test-26, the Eating Beliefs Questionnaire-18, the Hospital Anxiety and Depression Scale, the Toronto Alexithymia Scale-20, the Cognitive Emotion Regulation Questionnaire, and the Difficulties in Emotion Regulation Scale. Statistical analyses included: Student t - tests or Mann–Whitney U tests for testing group differences between BED and HC group, and Pearson’s r coefficient or Spearman’s rho for exploring associations between the emotion regulation difficulties and strategies, and clinical variables and binge-eating-related beliefs in both groups.

Results
The BED group presented with a significantly higher level of emotion regulation difficulties such as: nonacceptance of emotional responses, lack of emotional clarity, difficulties engaging in goal-directed behavior, impulse control difficulties, and limited access to emotion regulation strategies compared to the healthy controls. Moreover, patients with BED were significantly more likely to use maladaptive strategies (rumination and self-blame) and less likely to use adaptive strategies (positive refocusing and putting into perspective). In the clinical group, various difficulties in emotion regulation difficulties occurred to be positively correlated with the level of alexithymia, and anxiety and depressive symptoms. Regarding emotion regulation strategies, self-blame and catastrophizing were positively related to anxiety symptoms, but solely catastrophizing was related to the severity of eating disorder psychopathology.

Conclusions
Our results indicate an essential and still insufficiently understood role of emotional dysregulation in BED. An especially important construct in this context seems to be alexithymia, which was strongly related to the majority of emotion regulation difficulties. Therefore, it might be beneficial to pay special attention to this construct when planning therapeutic interventions, as well as to the maladaptive emotion regulation strategies self-blame and catastrophizing, which were significantly related to BED psychopathology.
MicroRNAs in oral fluids (saliva and gingival crevicular fluid) as biomarkers in orthodontics: systematic review and integrated bioinformatic analysis
Authors: Kapoor Priyanka , Chowdhry Aman , Bagga Dinesh Kumar , Bhargava Deepak , Aishwarya S. 
Published: October 2021

AbstractBackgroundMicroRNAs (miRNAs) are non-coding short, single-stranded RNA molecules that may serve as biomarkers for various inflammatory and molecular mechanisms underlying bone and tissue remodeling consequent to orthodontic force application.MethodsA thorough literature search in major databases was conducted in March 2021 to generate evidence for miRNAs in orthodontics, with prior PROSPERO registration. The initial search revealed 920 articles, subjected to strict selection criteria according to PRISMA, and resulted in final inclusion of four studies. Quality assessment by QUADAS-2 classified three studies as unclear risk-of-bias while the applicability was high. Further, bioinformatic analysis was performed to identify the target genes from the miRNA database (miRDB) and TargetScan databases and their protein-protein interaction pathways with the STRING analysis.ResultsMultiple miRNAs in gingival crevicular fluid (GCF) of orthodontic patients were seen, including miRNA-21, 27(a/b), 29(a/b/c), 34,146(a/b), 101, and 214 along with matrix metalloproteinases (MMPs)-1, 2, 3, 8, 9, 14 in one study. A statistically significant increase in expression of miRNA-29a/b/c,101, 21 from pre-treatment (before initiation of retraction) was seen to reach a peak at 4–6 weeks (wk) of retraction. On the contrary, miRNA-34a showed downregulation from the 1 day to 4 wk of retraction and also, negatively correlated with MMPs-2,9,14 levels at the same observation times. The distance of canine movement showed mild correlation with miRNA-27a/b, 214 at 2 wk of retraction. Bioinformatics revealed 1213 mutual target genes which were analyzed for inter-relational pathways using Cytoscape plugin, MCODE. Further, 894 prominent protein interactions were identified from the STRING database and SMAD4, IGF1, ADAMTS6, COL4A1, COL1A1, COL3A1, FGFR1, COL19A1, FBN1, COL5A1, MGAT4A, LTBP1, MSR1, COL11A1, and COL5A3 were recognized as the hub genes. Their interactions were able to isolate multiple miRNAs: hsa-miR-34a-5p, hsa-miR-29b-2-5p, hsa-miR-29b-3p, hsa-miR-34a-3p, hsa-miR-27a-5p, hsa-miR-29a-5p, hsa-miR-29b-1-5p, hsa-miR-29c-3p, hsa-miR-214-5p, hsa-miR-27a-3p, hsa-miR-29a-3p, hsamiR-146-5p, which were found promising as biomarkers for tooth movement.ConclusionsOur results support using miRNAs as biomarkers in varied orthodontic study designs and for inter-relationships with pathological settings like periodontal disease, pre-malignancies, or conditions like obesity or metabolic irregularities, etc. The identified target genes and their protein interaction pathways can be used to propose precision therapies, focusing on ideal tooth movement with minimal iatrogenic side-effects.
Prospects for the application of geothermal resources in agriculture in Poland taking account of the natural functions of the countryside
Authors: Skrzypczak Robert , Kępińska Beata , Pająk Leszek , Bujakowski Wiesław 
Published: October 2021

AbstractAgriculture is among the most promising applications of geothermal energy, and Poland has conditions to develop geothermal use in this sector. Suitable locations for agricultural geothermal installations shall be selected during the planning stage. To support the selection process, the authors chosed and analyzed thematic maps and other information on basic natural conditions for agriculture in Poland, potential conflicts between the operation of possible geothermal agricultural installations and other important functions of the natural environment, valuable natural areas and protection systems, elements of the current agricultural economy, etc. The authors combined them with the spatial distribution of geothermal reservoir parameters suitable for their agricultural applications using CorelDRAW X7 software. As a result, the regions with prospective geothermal applications in a sustainable agriculture can be identified, while maintaining the existing natural functions of the area. An example is given of the energetic, technical and economic calculations for agricultural greenhouses which can be supplied by geothermal resources in an area with existing natural functions, and a relevant study case is presented. The novel approach described in this paper may serve as an example in other countries of agricultural development with the use of geothermal resources.
More examples of breakdown the 1:1 partner specificity between figs and fig wasps
Authors: Yu Hui , Liao Yaolin , Cheng Yufen , Jia Yongxia , Compton Stephen G. 
Published: October 2021

AbstractBackgroundThe obligate mutualism between fig trees (Ficus, Moraceae) and pollinating fig wasps (Agaonidae) is a model system for studying co-evolution due to its perceived extreme specificity, but recent studies have reported a number of examples of trees pollinated by more than one fig wasp or sharing pollinators with other trees. This will make the potential of pollen flow between species and hybridization more likely though only few fig hybrids in nature have been found. We reared pollinator fig wasps from figs of 13 Chinese fig tree species and established their identity using genetic methods in order to investigate the extent to which they were supporting more than one species of pollinator (co-pollinator).ResultsOur results showed (1) pollinator sharing was frequent among closely-related dioecious species (where pollinator offspring and seeds develop on different trees); (2) that where two pollinator species were developing in figs of one host species there was usually one fig wasp with prominent rate than the other. An exception wasF. triloba, where its two pollinators were equally abundant; (3) the extent of co-pollinator within one fig species is related to the dispersal ability of them which is stronger in dioecious figs, especially in small species.ConclusionsOur results gave more examples to the breakdown of extreme specificity, which suggest that host expansion events where pollinators reproduce in figs other than those of their usual hosts are not uncommon among fig wasps associated with dioecious hosts. Because closely related trees typically have closely related pollinators that have a very similar appearance, the extent of pollinator-sharing has probably been underestimated. Any pollinators that enter female figs carrying heterospecific pollen could potentially generate hybrid seed, and the extent of hybridization and its significance may also have been underestimated.
Normalization and outlier removal in class center-based firefly algorithm for missing value imputation
Authors: Nugroho Heru , Utama Nugraha Priya , Surendro Kridanto 
Published: October 2021

AbstractA missing value is one of the factors that often cause incomplete data in almost all studies, even those that are well-designed and controlled. It can also decrease a study’s statistical power or result in inaccurate estimations and conclusions. Hence, data normalization and missing value handling are considered the major problems in the data pre-processing stage, while classification algorithms are adopted to handle numerical features. In cases where the observed data contained outliers, the missing value estimated results are sometimes unreliable or even differ greatly from the true values. Therefore, this study aims to propose the combination of normalization and outlier removals before imputing missing values on the class center-based firefly algorithm method (ON  +  C3FA). Moreover, some standard imputation techniques like mean, a random value, regression, as well as multiple imputation, KNN imputation, and decision tree (DT)-based missing value imputation were utilized as a comparison of the proposed method. Experimental results on the sonar dataset showed normalization and outlier removals effect in the methods. According to the proposed method (ON  +  C3FA), AUC, accuracy, F1-Score, Precision, Recall, and AUC-PR had 0.972, 0.906, 0.906, 0.908, 0.906, 0.61 respectively. The result showed combining normalization and outlier removals in C3-FA (ON  +  C3FA) was an efficient technique for obtaining actual data in handling missing values, and it also outperformed the previous studies methods with r and RMSE values of 0.935 and 0.02. Meanwhile, the Dks value obtained from this technique was 0.04, which indicated that it could maintain the values or distribution accuracy.
MuSe: a multi-level storage scheme for big RDF data using MapReduce
Authors: Chawla Tanvi , Singh Girdhari , Pilli Emmanuel S. 
Published: October 2021

AbstractResource Description Framework (RDF) model owing to its flexible structure is increasingly being used to represent Linked data. The rise in amount of Linked data and Knowledge graphs has resulted in an increase in the volume of RDF data. RDF is used to model metadata especially for social media domains where the data is linked. With the plethora of RDF data sources available on the Web, scalable RDF data management becomes a tedious task. In this paper, we present MuSe—an efficient distributed RDF storage scheme for storing and querying RDF data with Hadoop MapReduce. In MuSe, the Big RDF data is stored at two levels for answering the common triple patterns in SPARQL queries. MuSe considers the type of frequently occuring triple patterns and optimizes RDF storage to answer such triple patterns in minimum time. It accesses only the tables that are sufficient for answering a triple pattern instead of scanning the whole RDF dataset. The extensive experiments on two synthetic RDF datasets i.e. LUBM and WatDiv, show that MuSe outperforms the compared state-of-the art frameworks in terms of query execution time and scalability.
Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study
Authors: van der Heijden Jaap , Kolliopoulos Constantinos , Skorup Paul , Sallisalmi Marko , Heldin Paraskevi , Hultström Michael , Tenhunen Jyrki 
Published: October 2021

Abstract
Background
Plasma hyaluronan concentrations are increased during sepsis but underlying mechanisms leading to high plasma hyaluronan concentration are poorly understood. In this study we evaluate the roles of plasma hyaluronan, effective plasma hyaluronidase (HYAL) activity and its endogenous plasma inhibition in clinical and experimental sepsis. We specifically hypothesized that plasma HYAL acts as endothelial glycocalyx shedding enzyme, sheddase.

Methods
Plasma hyaluronan, effective HYAL activity and HYAL inhibition were measured in healthy volunteers (n = 20), in patients with septic shock (n = 17, day 1 and day 4), in patients with acute pancreatitis (n = 7, day 1 and day 4) and in anesthetized and mechanically ventilated pigs (n = 16). Sixteen pigs were allocated (unblinded, open label) into three groups: Sepsis-1 with infusion of live Escherichia coli (E. coli) 1 × 108 CFU/h of 12 h (n = 5), Sepsis-2 with infusion of E. coli 1 × 108 CFU/h of 6 h followed by 1 × 109 CFU/h of the remaining 6 h (n = 5) or Control with no E. coli infusion (n = 6).

Results
In experimental E. coli porcine sepsis and in time controls, plasma hyaluronan increases with concomitant decrease in effective plasma HYAL activity and increase of endogenous HYAL inhibition. Plasma hyaluronan increased in patients with septic shock but not in acute pancreatitis. Effective plasma HYAL was lower in septic shock and acute pancreatitis as compared to healthy volunteers, while plasma HYAL inhibition was only increased in septic shock.

Conclusion
Elevated plasma hyaluronan levels coincided with a concomitant decrease in effective plasma HYAL activity and increase of endogenous plasma HYAL inhibition both in experimental and clinical sepsis. In acute pancreatitis, effective plasma HYAL activity was decreased which was not associated with increased plasma hyaluronan concentrations or endogenous HYAL inhibition. The results suggest that plasma HYAL does not act as sheddase in sepsis or pancreatitis.
Rice husk hydrochars from metal chloride-assisted hydrothermal carbonization as biosorbents of organics from aqueous solution
Authors: Li Yin , Hagos Fana Mulugeta , Chen Rongrong , Qian Hanxin , Mo Chengxing , Di Jing , Gai Xikun , Yang Ruiqin , Pan Genxing , Shan Shengdao 
Published: October 2021

AbstractHydrochar a carbon-rich material resulting from hydrothermal carbonization of biomass, has received substantial attention because of its potential application in various areas such as carbon sequestration, bioenergy production and environmental amelioration. A series of hydrochars were prepared by metal chloride-assisted hydrothermal carbonization of rice husk and characterized by elemental analysis, zeta potential, X-ray diffraction, Brunauer–Emmett–Teller measurements, Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy and scanning electron microscopy. The results reveal that the prepared hydrochars have carbon contents ranging from 45.01 to 58.71%, BET specific areas between 13.23 and 45.97 m2/g, and rich O-containing functional groups on the surfaces. The metal chlorides added in the feedwater could improve the degree of carbonization and show significant effects on the physical, chemical and adsorption properties of the hydrochars. The adsorption of the selected organics on the hydrochars is a spontaneous and physisorption-dominated process. The hydrochars possess larger adsorption capacities for 2-naphthol than for berberine hydrochloride and Congo red, and the modeling maximum adsorption capacities of 2-naphthol are in the range of 170.1–2680 mg/g. The adsorption equilibrium could be accomplished in 10, 40 and 30 min for 2-naphthol, berberine hydrochloride and Congo red, respectively. These results suggest metal chloride-assisted hydrothermal carbonization a promising method for converting biomass waste into effective adsorbents for wastewater treatment.
Polyhydroxyalkanoate production from rice straw hydrolysate obtained by alkaline pretreatment and enzymatic hydrolysis using Bacillus strains isolated from decomposing straw
Authors: Van Thuoc Doan , Chung Nguyen Thi , Hatti-Kaul Rajni 
Published: October 2021

AbstractRice straw is an important low-cost feedstock for bio-based economy. This report presents a study in which rice straw was used both as a source for isolation of bacteria producing the biodegradable polyester polyhydroxyalkanoate (PHA), as well as the carbon source for the production of the polymer by the isolated bacteria. Of the 100 bacterial isolates, seven were found to be positive for PHA production by Nile blue staining and were identified as Bacillus species by 16S rRNA gene sequence analysis. Three isolates showed 100% sequence identity to B. cereus, one to B. paranthracis, two with 99 and 100% identity to B. anthracis, while one was closely similar to B. thuringiensis. For use in PHA production, rice straw was subjected to mild alkaline pretreatment followed by enzymatic hydrolysis. Comparison of pretreatment by 2% sodium hydroxide, 2% calcium hydroxide and 20% aqueous ammonia, respectively, at different temperatures showed maximum weight loss with NaOH at 80 °C for 5 h, but ammonia for 15 h at 80 °C led to highest lignin removal of 63%. The ammonia-pretreated rice straw also led to highest release of total reducing sugar up to 92% on hydrolysis by a cocktail of cellulases and hemicellulases at 50 °C. Cultivation of the Bacillus isolates on the pretreated rice straw revealed highest PHA content of 59.3 and 46.4%, and PHA concentration of 2.96 and 2.51 g/L by Bacillus cereus VK92 and VK98, respectively.