bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the sexual health of young people (under 25) in high-risk populations: a systematic review and meta-analysis of behavioural and psychosocial interventions.
Authors: Brown Ellie , Monaco Samantha L Lo , O'Donoghue Brian , Hughes Elizabeth , Graham Melissa , Simmons Magenta , Gray Richard 
Published: April 2021

Abstract
Background Ensuring young people experience good sexual health is a key public health concern. Yet, some vulnerable groups of young people are at higher risk of poor sexual health, and consequently require additional support to achieve good sexual health. Therefore, the aim of this systematic review was to identify and assess the evidence base for behavioural and psychosocial interventions to improve sexual health for young people with additional vulnerabilities.Methods We searched for randomised controlled trials of interventions aimed at promoting sexual health, with any non-pharmacological comparator (e.g., waitlist control). Key outcomes of interest were indicators of sexual health (e.g., condom use, attitudes to contraception, knowledge of risk). Participants in eligible trials were under 25 years old and in a high-risk group (alcohol and other drug use; justice-involved; homeless; LGBTQI+; mental ill-health; ethnic minority, or out-of-home care). The final literature searches were performed on 16 September 2020, on MEDLINE, PsycINFO, EMBASE, CENTRAL, Web of Science, Scopus and clinical trial registries. Meta-analyses were conducted where possible.Results Forty-seven papers from 46 trials of the 5213 identified met inclusion criteria, with all but one of the included trials conducted in North America. Three focused predominantly on AOD, six on juvenile justice, two on homelessness, five on young men who have sex with men (YMSM), 26 on ethnic minorities, two on mental ill-health, three on out-of-home care, however no trials were identified in LGBTQI + groups outside of YMSM. The 47 included papers had a combined total of 21,543 participants. The vast majority (26/46) of trials were conducted with ethnic minority groups, with most of the interventions delivered as group therapy, and some involving parents and caregivers. Condom use was the most frequently reported outcome measure. In trials targeting ethnic minorities, the meta-analysis found a medium effect size (0.62, p = 0.0004) of the intervention on condom use.Conclusions There remains a dearth of research undertaken outside of North America, and in high-risk groups other than ethnic minorities. Future interventions should address sexual health more broadly than just the absence of negative biological outcomes with LGBTQI+, homeless and mental ill-health populations targeted for such work.This review was registered at Prospero (ref. 149810) and at osf.io/ukva9.
Clinical significance of serum AMH and INHB in girls with precocious puberty
Authors: Liu Qingxu , Yin Xiaoqin , Li Pin 
Published: April 2021

Abstract
Background: Precocious puberty is the second sexual characteristic of girls before 8 years old. The diagnosis of central precocious puberty (CPP) needs to evaluate ovarian function, and ultrasound examination is an auxiliary means for the evaluation of ovary at present. The serum levels of AMH and INHB might be markers of evaluation of ovary according the former research. We investigated the clinical features, serum sex hormones, serum levels of AMH and INHB in 184 girls with precocious puberty, which provided deeper insight into the clinical significance of AMH and INHB in female precocious puberty. Methods: We evaluated 184 girls with precocious puberty at the Department of Endocrinology of Shanghai Children's Hospital from 2017 to 2021, which was consisted of PT, Tanner stage 2 CPP and Tanner stage 3 CPP. We analysed clinical data from the patients including clinical manifestations, AMH, INHB and other hormone levels, and we analysed AMH and INHB in normal control group either.Results: The PT group (P = 0.031) and Tanner stage 2 CPP group (P = 0.006) exhibited significantly higher AMH level than that in normal control group. AMH level showed no significant difference among PT group, Tanner stage 2 CPP group and Tanner stage 3 CPP group. The Tanner stage 2 CPP group exhibited significantly higher level of INHB than that in Tanner stage 3 CPP group (P = 0.013) and normal control group (P = 0.007). AMH and INHB were positively correlated in the four groups, especially in the PT group (r = 0.694**, P < 0.01). AMH and basal LH were positively correlated in PT group (r = 0.296*, P < 0.01). AMH or INHB showed no correlation with chronical age, bone age, uterine volume, ovarian volume, BMI, E2, SHBG, peak LH, basal FSH, peak FSH, IGF-1 or IGF-BP3. The ROC analysis showed that the AUC of AMH or INHB was relatively low. Conclusions: In this research, the serum AMH and INHB in 184 girls with precocious puberty were analysed. The PT group and Tanner stage 2 CPP group exhibited significantly higher AMH level than that in normal control group. The Tanner stage 2 CPP group exhibited significantly higher level of INHB than that in Tanner stage 3 CPP group and normal control group. AMH and INHB were positively correlated in the four groups, especially in the PT group. ROC analysis showed that the diagnostic performance of PT or CPP using AMH or INHB was weak.
Acute ischemic stroke with cervical internal carotid artery steno-occlusive lesion: multicenter analysis of endovascular approaches
Authors: Cirillo Luigi , Romano Daniele Giuseppe , Vornetti Gianfranco , Frauenfelder Giulia , Tamburrano Chiara , Taglialatela Francesco , Isceri Salvatore , Saponiero Renato , Napoletano Rosa , Gentile Mauro , Romoli Michele , Princiotta Ciro , Simonetti Luigi , Zini Andrea 
Published: April 2021

Abstract
Background

Occlusions of internal carotid artery (ICA), whether isolated or in tandem lesions (TL) have a poor response to treatment with intravenous thrombolysis. Previous studies ​​have demonstrated the superiority of mechanical thrombectomy in the treatment of acute ischemic stroke (AIS) following large vessel occlusion, compared to standard intravenous fibrinolysis. The aim of our study was to describe endovascular treatment (EVT) in AIS due to ICA occlusion, whether isolated or in TL.
Methods

we assessed the association between 90-day outcome and clinical, demographic, imaging and procedure data in 51 consecutive patients with acute isolated ICA or TL occlusion who underwent endovascular treatment (EVT). We evaluated baseline NIHSS and mRS, ASPECTS, type of occlusion, stent placement, use of stent retrievers and/or thromboaspiration, duration of the procedure, mTICI, procedural therapy and complications.
Results

A favorable 90-day outcome (mRS 0–2) was achieved in 34 patients (67%) and was significantly associated with the use of dual antiplatelet therapy after the procedure (p = 0.008), shorter procedure duration (p = 0.031), TICI 2b-3 (p < 0.001) and lack of post-procedural hemorrhagic transformation (p = 0.001). Four patients did not survive, resulting in a mortality rate of 8%
Conclusions

EVT in the treatment of AIS due to ICA occlusion is safe and effective; mortality rates are in agreement with the current literature. The use of the stent is safe and promotes good angiographic results, as well as therapy with a GpIIb / IIIa inhibitor immediately after stent release which is also associated with better 3-month outcome and good revascularization.
SI on economic costs of invasions -&nbsp;Feeling the pinch: global economic costs of crayfish invasions and comparison with other aquatic crustaceans
Authors: Kouba Antonin , Oficialdegui Francisco J. , Cuthbert Ross N. , Kourantidou Melina , South Josie , Tricarico Elena , Leroy Boris , Gozlan Rudolphe , Courchamp Franck , Haubrock Phillip J 
Published: April 2021

Abstract
Despite voluminous literature identifying invasive species impacts, understandings of monetary costs remain limited. Recently, profound impacts have been attributed to invasive crustaceans, but associated monetary costs lack synthesis. Here, we analyse globally reported costs of invasive freshwater crayfish across taxonomic, spatial and temporal descriptors. Moreover, we compare their cost magnitude to other invasive crustaceans — crabs, amphipods and lobsters. Between 2000 and 2020, crayfish caused US$ 1.28 billion in reported costs; the vast majority (95%) attributed to Astacidae (principally the signal crayfish Pacifastacus leniusculus) and the remainder to Cambaridae. According to reports, crayfish costs mostly impacted European economies (US$ 1.23 billion), followed by costs reported for North America and Asia. Despite well-known damages caused by invasive crayfish, costs were unreported elsewhere, highlighting knowledge gaps and challenges in cost quantifications. Invasive crayfish costs increased exponentially in the last two decades, averaging at US$ 61 million per-annum. Invasive crabs caused costs of similar magnitude (US$ 1.25 billion; US$ 53 million per-annum) but were mostly confined to North America (95%). Damage-related costs dominated for both crayfish (83%) and crabs (99%), with management spending lacking. Reported economic impacts from amphipods (US$ 178.8 thousand) and lobsters (US$ 44.6 thousand) were considerably lower. We identify burgeoning economic costs from these invasive groups yet highlight pervasive knowledge gaps at multiple scales. Further cost reporting is required to better-ascertain the true scale of monetary costs caused by invasive aquatic crustaceans.
Enhancing osteoblast function through pulsed electrical stimulation: implications for peri-implant healing and osseointegration
Authors: Pettersen Emily , Shah Furqan A. , Ortiz-Catalan Max 
Published: April 2021

Abstract

Electrical stimulation has been suggested as a mean for promoting the bonding of bone tissue to an implant, known as osseointegration. Previous work has investigated the impact of electrical stimulation in different models, both in vitro and in vivo, using various electrode configurations for delivering the electric field and with a wide range of stimulation parameters. However, there is no consensus on optimal electrode configuration nor stimulation parameters. Here, we investigated a novel approach of delivering electrical stimulation to a titanium implant using parameters clinically tested in a different application, namely peripheral nerve stimulation. We propose an in vitro model comprising of Ti6Al4V implants precultured with MC3T3-E1 preosteoblasts, stimulated for 72 h at two different pulse amplitudes (10 µA and 20 µA) and at two different frequencies (50 Hz and 100 Hz). We found that pulsed electrical stimulation enhances cell viability (and/or proliferation) and collagen production in an approximately dose-dependent manner. Our findings suggest that pulsed electrical stimulation with characteristics similar to peripheral nervous stimulation has the potential to accelerate osteoblast function and may provide a promising approach to improving peri-implant bone healing, particularly to neuromusculoskeletal interfaces in which implanted electrodes are readily available.
Health services for Indigenous children in remote Australia: a strategic literature review
Authors: Dossetor Philippa Jane , Thorburn Kathryn , Oscar June , Carter Maureen , Jeffery Heather E , Harley David , Elliott Elizabeth Jane , Martiniuk Alexandra LC 
Published: April 2021

Abstract
Introduction: There is a significant gap between health outcomes in Indigenous and non-Indigenous children, which may relate to inequity in health service provision, particularly in remote areas. We aim to review the literature to describe health services and their use by children living in remote Australia, comparing them to best practice models to identify opportunities for improvements.Methods: Electronic-databases of medical literature were searched from Jan 1990 to Dec 2013. Grey literature was identified through investigation of websites, including local, state and national health departments. Essential information was extracted and summarised for papers meeting inclusion criteria for the review.Results: A total of 45 titles was identified in a strategic search of electronic medical databases and 47 in the grey literature. Strict inclusion and exclusion criteria applied. Data were extracted from 92 documents.Conclusions: Barriers exist to effective child health service delivery in remote Australia including availability and access. Existing services cannot meet demand. Gold standard models for service delivery incorporating community engagement and collaboration should be explored. Increased resources and focus on primary prevention and health promotion are essential.
Predictors of 30-Day Mortality Using Machine Learning Approach following Carotid Endarterectomy: An Insight from National Surgical Quality Database
Authors: Fatima Nida , MD FR FAHA Ashfaq Shuaib , MD F MPH Maher Saqqur 
Published: April 2021

Abstract
BACKGROUND: Pre-operative prognostication of 30-day mortality in patients with carotid endarterectomy (CEA) can optimize surgical risk stratification and guide the decision-making process to improve survival. To develop and validate a set of predictive variables of 30-day mortality following CEA.METHODS: The patient cohort was identified from the American College of Surgeons National Surgical Quality Improvement Program (2005-2016). We performed logistic regression (enter, stepwise and forward) and least absolute shrinkage and selection operator (LASSO) method for selection of variables, which resulted in 28-candidate models. The final model was selected based upon clinical knowledge and numerical results.RESULTS: Statistical analysis included 65,807 patients with 30-day mortality in 0.7% (n=466) patients. The median age of our cohort was 71.0 years (range, 16-89 years). The model with 9-predictive factors which included: age, body mass index, functional health status, American society of anesthesiologist grade, chronic obstructive pulmonary disorder, preoperative serum albumin, preoperative hematocrit, preoperative serum creatinine and preoperative platelet count—performed best on discrimination, calibration, Brier score and decision analysis to develop a machine learning algorithm. Logistic regression showed higher AUCs than LASSO across these different models. The predictive probability derived from the best model was converted into an open-accessible scoring system.CONCLUSION: Machine learning algorithms show promising results for predicting 30-day mortality following CEA. These algorithms can be useful aids for counseling patients, assessing pre-operative medical risks, and predicting survival after surgery.
Solar zenith angle dependence of relationships between energy inputs to the ionosphere and ion outflow fluxes
Authors: Kitamura Naritoshi , Seki Kanako , Keika Kunihiro , Nishimura Yukitoshi , Hori Tomoaki , Hirahara Masafumi , Lund Eric J , Kistler Lynn M , Strangeway Robert J 
Published: April 2021

Abstract
The ionosphere is one of the important sources for magnetospheric plasma, particularly for heavy ions with low charge states. We investigate the effect of solar illumination on the number flux of ion outflow using data obtained by the Fast Auroral SnapshoT satellite at 3000–4150 km altitude from 7 January 1998 to 5 February 1999. We derive empirical formulas between energy inputs and outflowing ion number fluxes for various solar zenith angle ranges. We found that the outflowing ion number flux under sunlit conditions increases more steeply with increasing electron density in the loss cone or with increasing precipitating electron density (> 50 eV), compared with the ion flux under dark conditions. Under ionospheric dark conditions, weak electron precipitation can drive ion outflow with small averaged fluxes (~ 107 cm− 2 s− 1). The slopes of relations between the DC and Alfvén Poynting fluxes and outflowing ion number fluxes show no clear dependence on solar zenith angle. Intense ion outflow events (> 108 cm− 2 s− 1) occur mostly under sunlit conditions (solar zenith angle < 90°). Thus, it is presumably difficult to drive intense ion outflows under dark conditions, because of a lack of the solar illumination (low ionospheric density and/or small scale height owing to low plasma temperature).
Outcomes of Ahmed Glaucoma Valv Implantation in Patients with Pars Plana Vitrectomy History
Authors: Subasi Sevgi , Yuksel Nursen , Karabas Levent Veysel , Tugan Busra Yilmaz , Basaran Ece 
Published: April 2021

Abstract
Background and Objective: Ahmed glaucoma valv (AGV) implantation is one of the successful surgical methods in secondary glaucoma that develops after pars plana vitrectomy (PPV). In our study, we aimed to evaluate the 1-year results of AGV implantation in patients with a history of PPV.Study Design: A total of 26 patients who underwent AGV implantation after PPV were included in our retrospective study. Fourteen of 26 patients had AGV implantation due to neovascular glaucoma (NVG) and 12 of them had secondary refractory galucoma. Data of these two groups of patients were evaluated in terms of IOP reduction, number of medication use, surgical complete and qualified success, surgical failure, and complications.Results: The mean IOP was 29.54±4.87 mmHg at the preoperative of AGV implantation and 12.88±4.17 at the twelfth month visit in overal group. There was no statistically significant difference between two groups in terms of IOP in preoperative and all postoperative visits (p>0.05). The mean intervals between PPV and AGV implantation were 67 ± 34 days in NVG and 391 ± 500 days in non-NVG group (p=0.017). In overal group, 91.7% of patients had improvement in BCVA at the twelfth month visit. Complete and qualified surgical success rates were 75%, 83.3% in NVG group and 50%, 91.7% in non-NVG group respectively. There was no devastating complication in both group.Conclusion: AGV implantation is a safe and effective surgical method in uncontrolled IOP elevations after PPV. While surgical success and failure rates was similar between etiologies, the time required for AGV implantation after PPV was shorter in NVG etiology.
Colitis ulcerativa para no gastroenterólogos
Authors: Zuluaga Arbeláez Nicolás , Sierra Vargas Elsy Cristina , Díaz Coronado Juan Camilo , Guevara Casallas Luis Gonzalo 
Published: April 2021

La colitis ulcerativa es una enfermedad intestinal inflamatoria crónica, de etiología idiopática y fisiopatología multifactorial, caracterizada por la inflamación de la mucosa rectal, con extensión proximal, continua y simétrica a través del colon. Su diagnóstico se establece a partir de los hallazgos clínicos, endoscópicos e histológicos. La meta terapéutica es lograr la remisión clínica y endoscópica, reducir el riesgo de colectomía, cáncer colorrectal y mejorar la calidad de vida de los pacientes. Se realizó una búsqueda de artículos científicos y se exponen los aspectos más relevantes y actualizados sobre la enfermedad; con el objetivo de proporcionar elementos para su abordaje diagnóstico y terapéutico.
Effects of the Interactive Web-Based Video “Mon Coeur, Mon BASIC” on Drug Adherence of Patients With Myocardial Infarction: Randomized Controlled Trial
Authors: Bruggmann Christel , Adjedj Julien , Sardy Sylvain , Muller Olivier , Voirol Pierre , Sadeghipour Farshid 
Published: April 2021

Background
Secondary prevention strategies after acute coronary syndrome (ACS) presentation with the use of drug combinations are essential to reduce the recurrence of cardiovascular events. However, lack of drug adherence is known to be common in this population and to be related to treatment failure. To improve drug adherence, we developed the “Mon Coeur, Mon BASIC” video. This online video has been specifically designed to inform patients about their disease and their current medications. Interactivity has been used to increase patient attention, and the video can also be viewed on smartphones and tablets.

Objective
The objective of this study was to assess the long-term impact of an informative web-based video on drug adherence in patients admitted for an ACS.

Methods
This randomized study was conducted with consecutive patients admitted to University Hospital of Lausanne for ACS. We randomized patients to an intervention group, which had access to the web-based video and a short interview with the pharmacist, and a control group receiving usual care. The primary outcome was the difference in drug adherence, assessed with the Adherence to Refills and Medication Scale (ARMS; 9 multiple-choice questions, scores ranging from 12 for perfect adherence to 48 for lack of adherence), between groups at 1, 3, and 6 months. We assessed the difference in ARMS score between both groups with the Wilcoxon rank sum test. Secondary outcomes were differences in knowledge, readmissions, and emergency room visits between groups and patients’ satisfaction with the video.

Results
Sixty patients were included at baseline. The median age of the participants was 59 years (IQR 49-69), and 85% (51/60) were male. At 1 month, 51 patients participated in the follow-up, 50 patients participated at 3 months, and 47 patients participated at 6 months. The mean ARMS scores at 1 and 6 months did not differ between the intervention and control groups (13.24 vs 13.15, 13.52 vs 13.68, respectively). At 3 months, this score was significantly lower in the intervention group than in the control group (12.54 vs 13.75; P=.03). We observed significant increases in knowledge from baseline to 1 and 3 months, but not to 6 months, in the intervention group. Readmissions and emergency room visits have been very rare, and the proportion was not different among groups. Patients in the intervention group were highly satisfied with the video.

Conclusions
Despite a lower sample size than we expected to reach, we observed that the “Mon Coeur, Mon BASIC” web-based interactive video improved patients’ knowledge and seemed to have an impact on drug adherence. These results are encouraging, and the video will be offered to all patients admitted to our hospital with ACS.

Trial Registration
ClinicalTrials.gov NCT03949608; https://clinicaltrials.gov/ct2/show/NCT03949608