bluuebunny/crossref_metadata_2025_split huggingface dataset:
The LOWER URINARY TRACT SYMPTOMS IN ANURIA AND NON-ANURIA PATIENTS AFTER RENAL TRANSPLANTATION: A COMPARATIVE STUDY
Authors: Rahmita Maulidina Medika , Harrina Erlianti Rahardjo  , Arry Rodjani  , Nur Rasyid  
Published: July 2021

Objective: The purpose of this study is to examine the difference of lower urinary tract (LUT) symptoms in anuric and non-anuric individuals after renal transplantation (RT). Material & Methods: LUT function and symptoms were assessed in subjects who had undergone RT at Cipto Mangunkusumo General Hospital, Jakarta, from November 2016 to June 2017. Subjects were divided into anuric and non-anuric groups. We excluded patients with surgical complications that could not undergo uroflowmetry. Results: Thirty-two (21 male, 11 female) subjects were recruited in this study. The anuric subjects were younger than the non-anuric ones (47 ± 12.82 vs. 51.31 ± 16.33, p < 0.001) There were no significant differences in the International Prostate Symptoms Score (IPSS) (6.5 ± 3.67 vs. 6.25 ± 2.95, p = 0.567), Overactive Bladder Symptoms Score (OABSS) (4.06 ± 2.01 vs 4.12 ± 2.39, p = 1.000), maximum urinary flow rate (Qmax) (20.32 ± 9.04 vs. 22.32 ± 10.31, p = 0.956), post-void residual (PVR) (41.12 ± 37.63 vs. 47.62 ± 38.63, p = 0.361) and voided volume (227.88 ± 112.30 vs 251.06 ± 126.75, p = 0.588) between anuric and non-anuric subjects, respectively. IPSS-voiding symptom, IPSS-storage symptom, and OAB symptom did not differ significantly between both groups (p > 0.05). Thirteen (13/16) and seven (7/16) subjects of the anuric and non-anuric groups were both pleased with their quality of life, respectively. Conclusion: LUT symptoms do not differ between anuric and non-anuric patients.
CLINICAL EVALUATION OF TENCKHOFF CATHETER INSERTION IN PAEDIATRIC PERITONEAL DIALYSIS : A SINGLE CENTER STUDY
Authors: Nurkholiq Syahdat , Ghinorawa Tanaya 
Published: July 2021

Objective: This study aimed to evaluate the clinical outcome of Tenckhoff catheter insertion at Sardjito General Hospital for pediatric renal failure. Material & Methods: Data were collected from January 2014 to December 2018 at Sardjito General Hospital. All patient records were collected retrospectively such as patient characteristics, underlying diseases of kidney failure, congenital abnormalities, surgical technique, complications that occur after Tenckhoff catheter insertion. Results: 45 patients meet the inclusion criteria. A total of 7 patients with acute kidney failure (15.5%) and 38 patients with chronic kidney failure (84.5%). Glomerulonephritis is the most common cause of kidney failure (21 patients, 46.7%). The insertion technique used was open surgery in 34 patients (76%) and laparoscopic insertion in 11 patients (24%). Complications reported were catheter dysfunction, leakage of dialysate, surgical site infection, and peritonitis. Conclusion: Tenckhoff catheter insertion for peritoneal dialysis (PD) in pediatric patients with acute and chronic renal failure performed in our center is effective and safe. The most common cause of renal failure in pediatric is glomerulonephritis. Open surgery and laparoscopic insertion of Tenckhoff catheter both have a low complication rate. Catheter dysfunction due to mechanical catheter obstruction is one of the main problems in the placement of Tenckhoff catheter.
MALE URETHRAL STRICTURE CHARACTERISTIC IN DR KARIADI GENERAL HOSPITAL SEMARANG: A DESCRIPTIVE STUDY
Authors: Parulian Pasaribu Erwin , Daniswara Nanda , Santosa Ardy , Agung Nugroho Eriawan , Soedarso M. Adi , Rais Adin Sofyan 
Published: July 2021

Objective: This research was conducted to describe male urethral stricture characteristic in Kariadi General Hospital Semarang. Material & Methods: The data is collected retrospectively from the male urethral stricture patient medical records Kariadi General Hospital Semarang between January 2013 until December 2017. The data is analyzed descriptively to describe the characteristics of male urethral stricture patients, patient age, etiology, site, definitive surgery, and complications. Results: Within the period, 171 patients with male urethral stricture. The mean age was 52.11 years (range 9-86). The causes of stricture were trauma in 145 patients (84.8%), infection in 25 patients (14.6%) and iatrogenic in 1 patients (0.06%). Strictures site were posterior in 146 patients (85.4%) and anterior in 25 patients (14.6%). The definitive surgery for strictures were from DVIU in 132 patients (77.2%) and urethroplasty in 39 patients (22.8%). Complications rate were recurrence of stricture 56 patients (32.74%), bleeding 6 patients (3.05%), extravasation 14 patients (8.18%), erectile dysfunction 4 patients (2.34%). Conclusion: Trauma is the leading cause of urethral stricture in Kariadi General Hospital. The most common definitive therapy for urethral stricture in Kariadi General Hospital was still DVIU, but there has been an increase for urethroplasty and we still get the learning curve for it.
THE EFFICACY COMPARISON OF MIRABEGRON AS A MONOTHERAPY VERSUS ITS COMBINATION WITH SOLIFENACIN IN OVERACTIVE BLADDER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Madani Hasan , Soetojo  , Djatisoesanto Wahjoe 
Published: July 2021

Objective: This review aimed to evaluate the efficacy and safety of mirabegron as monotherapy and its combination with solifenacin for patients with overactive bladder (OAB). Material & Methods: A systematic search was conducted in PubMed, Google Scholar, and Science Direct using the keywords Overactive bladder or OAB and mirabegron or beta-3 agonist or β3 adrenoreceptor agonist and solifenacin or antimuscarinic based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline to include relevant randomized controlled trials (RCT)s. The included studies were assessed for their risks of bias using the Cochrane risk of bias tool for randomized controlled trials. Quantitative analysis using forest plot was performed in Review Manager 5.4. Results: A total of 4 RCTs were included from 227 studies. A fixed-effects model was chosen due to the low level of heterogeneity between the studies (I2 = 0%). The average micturition volume of patients in the combination group is higher compared to the monotherapy group (MD 17.13, 95% CI 12.78 - 21.48, p < 0.00001). The mean micturition frequency (MD - 0.54, 95% CI - 0.73 - -0.34, p < 0.00001) and incontinence incidence (MD -0.30, 95% CI -0.48 - -0.12, p = 0.001) in the combined group are significantly lower compared to the monotherapy group. Conclusion: The combination of mirabegron and solifenacin has better efficacy compared to mirabegron as monotherapy for OAB patients with a therapy duration of less than 12 weeks based on the micturition volume, micturition frequency, and incontinence incidence. The administration of combination therapy would not increase adverse event incidence compared to monotherapy.
Pengembangan Bahan Ajar Tematik Berbasis Proyek untuk Mengembangkan Keterampilan Berpikir Kreatif dan Karakter Wirausaha Peserta Didik Tunanetra
Authors: Fatimah Siti , , Budiono 
Published: July 2021

Penelitian ini bertujuan untuk mengembangkan bahan ajar tematik berbasis proyek untuk meningkatkan keterampilan berpikir kreatif dan karakter wirausaha peserta didik tunanetra. Desain pengembangan bahan ajar menggunakan pendekatan Design Based Research (DBR). Tahapan DBR yang digunakan terdiri dari empat tahap, yaitu tahap analisis kebutuhan, tahap desain/ pengembangan produk, tahap pengujian produk, dan tahap refleksi. Subjek dalam penelitian ini adalah 2 peserta didik tunanetra di SLB Putra Manunggal Gombong, Kebumen. Instrumen yang digunakan adalah lembar angket, lembar wawancara, lembar observasi, dan lembar tes. Teknik analisis data menggunakan deskriptif kualitatif. Hasil penelitian menunjukkan: 1) Bahan ajar tematik berbasis proyek layak digunakan bagi peserta didik tunanetra; 2) Pembelajaran proyek menggunakan bahan ajar tematik efektif meningkatkan keterampilan berpikir kreatif dan karakter wirausaha peserta didik tunanetra; 3) Besar pengembangan karakter wirausaha peserta didik tunanetra menunjukkan kategori tinggi/baik yaitu dengan persentase sebesar 84%, sedangkan peningkatan keterampilan berpikir kreatif peserta didik menunjukkan kategori sedang dengan nilai N-Gain 0,60.
Comportamiento del Midazolam administrado con tres diferentes vehículos para sedación consciente Estudio retrospectivo
Authors: Muñoz Villanueva de Evans Magali Natalia , Gonzales Mendoza Julio César Isaías 
Published: July 2021

Ante situaciones de miedo y ansiedad algunos pacientes requieren tratamientos bajo sedación consciente con midazolam, el cual requiere de ser mezclado con algún vehículo para su administración, sin embargo existe poca información de cómo este podría afectar su absorción. Objetivo: evaluar el nivel de sedación consciente en relación a la administración oral de midazolam con tres vehículos diferentes. Material y métodos: estudio observacional, retrospectivo y comparativo de 45 reportes de sedación consciente de los cuales, 20 cumplieron con los criterios de inclusión. Los datos fueron tomados de las histórias clínicas y analizados evaluando edad, sexo, comparando el nivel de sedación a traves de la escala de Houpt y los vehículos empleados (Paracetamol, jugo de frutas y azucar con jugo en cuchara). Se empleó el programa estadístico SPSS para la prueba chí cuadrado, analisis de frecuencia, moda y media para el análisis de los datos, con un nivel de significancia de 5%. Resultados: En cuanto a la somnolencia la mayoría de los pacientes presentó Houpt nivel 3 (somnoliento). En cuanto al movimiento no se encontró diferencia significativa según el vehículo utilizado. En cuanto al llanto, la mayoría de los pacientes presentó un nivel 3 y 4. Conclusión: La dilución del midazolam en jugo mostró mejores resultados en cuanto a somnolencia y llanto, pero estas diferencias no fueron estadísticamente significativas mostrando que los tres vehículos podrían ser útiles para la administración del midazolam vía oral.
Recovering Marine Gravity Over the Gulf of Guinea From Multi-Satellite Sea Surface Heights
Authors: Annan Richard Fiifi , Wan Xiaoyun 
Published: July 2021

A regional gravity field product, comprising vertical deflections and gravity anomalies, of the Gulf of Guinea (15°W to 5°E, 4°S to 4°N) has been developed from sea surface heights (SSH) of five altimetry missions. Though the remove-restore technique was adopted, the deflections of the vertical were computed directly from the SSH without the influence of a global geopotential model. The north-component of vertical deflections was more accurate than the east-component by almost three times. Analysis of results showed each satellite can contribute almost equally in resolving the north-component. This is attributable to the nearly northern inclinations of the various satellites. However, Cryosat-2, Jason-1/GM, and SARAL/AltiKa contributed the most in resolving the east-component. We attribute this to the superior spatial resolution of Cryosat-2, the lower inclination of Jason-1/GM, and the high range accuracy of the Ka-band of SARAL/AltiKa. Weights of 0.687 and 0.313 were, respectively, assigned to the north and east components in order to minimize their non-uniform accuracy effect on the resultant gravity anomaly model. Histogram of computed gravity anomalies compared well with those from renowned models: DTU13, SIOv28, and EGM2008. It averagely deviates from the reference models by −0.33 mGal. Further assessment was done by comparing it with a quadratically adjusted shipborne free-air gravity anomalies. After some data cleaning, observations in shallow waters, as well as some ship tracks were still unreliable. By excluding the observations in shallow waters, the derived gravity field model compares well in ocean depths deeper than 2,000 m.
Giga-Cycle Fatigue Behavior of the Nuclear Structure of 316L Weldments
Authors: Xiong Zhihong , Peng Engao , Zeng Lianghua , Xu Qirong 
Published: July 2021

Some components made of 316L stainless steel in nuclear reactors are connected by welding, and these are under giga-cycle fatigue loading. Therefore, the giga-cycle fatigue behavior of 316L weldments, which are fabricated by Laser Beam Welding (LBW) and Gas Tungsten Arc Welding (GTAW), were investigated using an ultrasonic fatigue testing system. The results indicate that the fatigue strength of LBW-made weldments is almost the same as that of GTAW-made weldments even though the microstructure and mechanical properties of the weldments are different. For the LBW-made specimens, the LBW-induced internal pores with a diameter range of about 89–270 μm were observed in the fracture surface. However, an obvious decrease in fatigue life was not observed in such cases. For the GTAW-made specimens, the quality requirement of the weld seam has to be more strict to prevent fatigue strength from decreasing. The fatigue failure mode of the GTAW-made specimens is the same as that of LBW-made specimens in the high-cycle fatigue regime but different in the giga-cycle fatigue regime.
The Impact of High-Fat Diet and Restrictive Feeding on Natural Killer Cells in Obese-Resistant BALB/c Mice
Authors: Spielmann Julia , Naujoks Wiebke , Emde Matthias , Allweyer Martin , Fänder Johannes , Kielstein Heike , Quandt Dagmar , Bähr Ina 
Published: July 2021

Background: The association of obesity and an increased risk for severe infections and various cancer types is well-described. Natural killer (NK) cells are circulating lymphoid cells and promoters of the immune response toward viruses and malignant cells. As demonstrated in previous studies the phenotype and functionality of NK cells is impaired in obesity. So far, the majority of animal studies were exclusively performed using ad libitum feeding regimes and it remained unclear whether NK cell alterations are mediated by obesity-associated immunological changes or by direct effects of the dietary composition. Therefore, the aim of the present study was to characterize NK cells in the peripheral blood of obese-resistant BALB/c mice supplied a normal-fat diet (NFD) or high-fat diet (HFD), ad libitum or in a restrictive manner.Methods: Twenty-eight BALB/c-mice were fed a NFD or HFD either ad libitum or in a restrictive feeding regime with 90% of the mean daily diet supply of the corresponding ad libitum group (each group n = 7). Blood and visceral adipose tissue were collected for flow cytometric analysis, analysis of plasma cytokine concentrations by multiplex immunoassay and real-time RT-PCR analyses. For statistical analyses two-way ANOVA with the factors “feeding regime” and “diet” was performed followed by a post-hoc Tukey's multiple comparison test and to compare means of the four mouse groups.Results:Ad libitum-feeding of a HFD in BALB/c mice has no influence on body weight gain, visceral fat mass, plasma cytokine concentrations, immune cell populations as well as the number, frequency and phenotype of NK cells. In contrast, restrictive feeding of a HFD compared to NFD led to significantly higher body weights, visceral fat mass and plasma interferon-γ concentrations which was associated with changes in the frequencies of granulocytes and NK cell subsets as well as in the surface expression of NK cell maturation markers.Conclusion: Results demonstrate for the first time that HFD-induced alterations in NK cells are consequences of the obese associated immunological profile rather than a direct effect of the dietary composition. These data can help to clarify the increased risk for cancer and severe infections in obesity.
Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration
Authors: Parra-Guillen Zinnia P. , Freshwater Tomoko , Cao Youfang , Mayawala Kapil , Zalba Sara , Garrido Maria J. , de Alwis Dinesh , Troconiz Iñaki F. 
Published: July 2021

V937 is an investigational novel oncolytic non-genetically modified Kuykendall strain of Coxsackievirus A21 which is in clinical development for the treatment of advanced solid tumor malignancies. V937 infects and lyses tumor cells expressing the intercellular adhesion molecule I (ICAM-I) receptor. We integrated in vitro and in vivo data from six different preclinical studies to build a mechanistic model that allowed a quantitative analysis of the biological processes of V937 viral kinetics and dynamics, viral distribution to tumor, and anti-tumor response elicited by V937 in human xenograft models in immunodeficient mice following intratumoral and intravenous administration. Estimates of viral infection and replication which were calculated from in vitro experiments were successfully used to describe the tumor response in vivo under various experimental conditions. Despite the predicted high clearance rate of V937 in systemic circulation (t1/2 = 4.3 min), high viral replication was observed in immunodeficient mice which resulted in tumor shrinkage with both intratumoral and intravenous administration. The described framework represents a step towards the quantitative characterization of viral distribution, replication, and oncolytic effect of a novel oncolytic virus following intratumoral and intravenous administrations in the absence of an immune response. This model may further be expanded to integrate the role of the immune system on viral and tumor dynamics to support the clinical development of oncolytic viruses.
Microvolt T-Wave Alternans Is Modulated by Acute Low-Level Tragus Stimulation in Patients With Ischemic Cardiomyopathy and Heart Failure
Authors: Kulkarni Kanchan , Stavrakis Stavros , Elkholey Khaled , Singh Jagmeet P. , Parks Kimberly A. , Armoundas Antonis A. 
Published: July 2021

Aims: Microvolt T-wave alternans (TWA), an oscillation in T-wave morphology of the electrocardiogram (ECG), has been associated with increased susceptibility to ventricular tachy-arrhythmias, while vagus nerve stimulation has shown promising anti-arrhythmic effects in in vivo and ex vivo animal studies. We aimed to examine the effect of non-invasive, acute low-level tragus stimulation (LLTS) on TWA in patients with ischemic cardiomyopathy and heart failure.Methods: 26 patients with ischemic cardiomyopathy (left ventricular ejection fraction &lt;35%) and chronic stable heart failure, previously implanted with an automatic implantable cardioverter defibrillator (ICD) device with an atrial lead (dual chamber ICD or cardiac resynchronization therapy defibrillator), were enrolled in the study. Each patient sequentially received, (1) Sham LLTS (electrode on tragus, but no stimulation delivered) for 5 min; (2) Active LLTS at two different frequencies (5 and 20 Hz, 15 min each); and (3) Active LLTS, during concomitant atrial pacing at 100 bpm at two different frequencies (5 and 20 Hz, 15 min each). LLTS was delivered through a transcutaneous electrical nerve stimulation device (pulse width 200 μs, frequency 5/20 Hz, amplitude 1 mA lower than the discomfort threshold). TWA burden was assessed using continuous ECG monitoring during sham and active LLTS in sinus rhythm, as well as during atrial pacing.Results: Right atrial pacing at 100 bpm led to significantly heightened TWA burden compared to sinus rhythm, with or without LLTS. Acute LLTS at both 5 and 20 Hz, during sinus rhythm led to a significant rise in TWA burden in the precordial leads (p &lt; 0.05).Conclusion: Acute LLTS results in a heart-rate dependent increase in TWA burden.
A Comparison of In-flight and Ground-Based Emergency Medical Events on the Clinical Demand for Outreach Medical Services at Taoyuan International Airport, Taiwan
Authors: Lo Chin-Hsiang , Shiao Yu-Feng , Hsu Shih-Tien 
Published: July 2021

Background: Limited information is available covering all medical events managed by the airport-based outreach medical service. This study explores the clinical demand for emergency medical outreach services at Taoyuan International Airport (TIA), Taiwan.Methods: Electronic medical records collected from TIA medical outreach services from 2017 to 2018, included passengers' profiles, flight information, events location, chief complaints, diagnosis (using ICD-9 -CM codes), and management outcomes. Medical events distribution was stratified by location and ages, and were compared statistically.Results: Among 1,501 eligible records, there were 81.8% ground-based emergency medical events (GBME), 16.9% in-flight medical events (IFME) managed after scheduled landing, and 1.3% IFME leading to unscheduled diversion or re-entry to TIA. The top three GBME diagnoses were associated with neurological (23.3%), gastrointestinal (21.2%), and trauma-related (19.3%) conditions. The top three IFME diagnosis that prompted unscheduled landings via flight diversion or re-entry were neurological (47.4%), psychological (15.8%), and cardiovascular (10.5%). The chief complaints that prompted unscheduled landings were mostly related to neurological (42.1%), cardiovascular (26.3%), and out-of-hospital cardiac arrest (OHCA) (10.5%) symptoms. A higher frequency of IFME events due to dermatologic causes in patients aged ≤ 18 years compared with adults and older adults (19 vs. 1.5% and 0, respectively); and a higher frequency of IFME due to cardiovascular causes in adults ≥ 65 years compared with patients aged ≤ 65 (15.1 vs. 9%). Among all IFME patients, six out-of-hospital deaths occurred among passengers from scheduled landings and two deaths occurred among 18 IFME passengers who were transferred to local hospitals from flight diversion or re-entry. A statistically significant difference in outcomes and short-term follow-up status was found between patients with IFME and those with GBME (p &lt; 0.001).Conclusion: Ground-based emergency medical events exceeded in-flight medical events at TIA. The most frequent events were related to neurological, gastrointestinal symptoms, or trauma. Results of this study may provide useful information for training medical outreach staff and preparing medical supplies to meet the clinical demand for airport medical outreach services.
Bibliometric Review to Explore Emerging High-Intensity Interval Training in Health Promotion: A New Century Picture
Authors: You Yanwei , Li Wenkai , Liu Jianxiu , Li Xingtian , Fu Yingyao , Ma Xindong 
Published: July 2021

Background: High-intensity interval training (HIIT) is an emerging exercise strategy and is considered to be a recipe for health promotion. This study aimed to systematically identify collaboration networks, track research trends, highlight current hotspots, and predict future frontiers in HIIT and its applications in health promotion since the start of the new century.Methods: Relevant original publications were obtained from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) database between 2001 and 2020. CiteSpace and VOSviewer software were used to perform bibliometric visualization and comparative analysis of involved indexes that included countries, institutions, journals, authors, references, and keywords.Results: A total of 572 papers were included, and the trend of annual publications showed a remarkable growth. The United States and the University of Exeter were the most productive country and institutions, respectively, with 107 and 18 publications, respectively. European Journal of Applied Physiology took the lead in the number of published articles, and Medicine and Science in Sports and Exercise ranked first in the cocitation counts. Barker AR and Gibala MJ were considered as the most productive and the most highly-cited authors.Conclusions: “Health risks,” “adolescent,” and “aging” are the three noteworthy topics during the evolution of HIIT-health promotion (HIIT-HP) research. The current research hotspots of HIIT and its practices in the health promotion domain lies in “metabolic diseases,” “cardiovascular diseases,” “neurological diseases,” and “musculoskeletal diseases.” The authors summarize that “prevention and rehabilitation,” “micro and molecular level,” and “cognition and mental health” are becoming frontiers and focus on the health topics related to HIIT in the upcoming years, which are worthy of further exploration.