bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of a short one-on-one nursing intervention in people with coronary heart disease
Authors: Xia Wen , Liu Ting , Lei Jie 
Published: January 2021

Abstract

Background:
To assess the efficacy of a short one-on-one nursing intervention in people with coronary heart disease (CHD).

Methods:
The experiment will be implemented from January 2021 to May 2021 at Wuhan No.1 Hospital. The experiment was granted through the Research Ethics Committee of Wuhan No.1 Hospital (W202012-8) and recorded in research registry (researchregistry6378). Patients are eligible for the study if they have a diagnosis of CHD, confirmed by their physician and lived independently. Exclusion criteria are:

Results:
Table 1 reflects the comparison of the biochemical and clinical variables and the lifestyle factors.

Conclusion:
A relatively short education may increase knowledge, attitudes and beliefs about ACS and response to ACS symptoms in individuals with CHD.

Trial registration number:
researchregistry6378
Relationship between A1166C polymorphism of angiotensin II type 1 receptor gene and arteriosclerosis
Authors: Shi Zhongping , Wang Jun , Chen Shanjiang , Dai Haiyue , Huang Yiwei 
Published: January 2021

Abstract

Background:
Arteriosclerosis has genetic correlation. Many studies have shown that angiotensin II type 1 receptor (AT1R) gene A1166C polymorphism is highly associated with arteriosclerosis, but there is no evidence-based basis. The purpose of this study is to systematically evaluate the relationship between AT1R gene A1166C polymorphism and arteriosclerosis.

Methods:
The search time is set from the establishment of the database in December 2020 in this study. The search database include China National Knowledge Infrastructure (CNKI), Wanfang, VIP and China Biology Medicine disc (CBM), PubMed, EMBASE, Web of Science, and the Cochrane Library. The subjects are observational studies on the relationship between AGTR1 A1166C polymorphism and arteriosclerosis (including case-control study, cross-sectional study, and cohort study). The language is limited to English and Chinese. The data of the included study are extracted and the literature quality is evaluated by 2 researchers independently. The data are statistically analyzed by Stata 16.0 software.

Results:
This study will use pulse wave velocity as an index to evaluate arteriosclerosis to explore the relationship between AT1R gene A1166C polymorphism and arteriosclerosis.

Conclusion:
This study will provide evidence-based medicine for elucidating the genetic tendency of arteriosclerosis.

Ethics and dissemination:
Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval will not be required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.

OSF Registration number:
DOI 10.17605/OSF.IO/V6E2Y
Prevalence and predictive nomogram of depression among hypertensive patients in primary care
Authors: Wang Lin , Li Nanfang , Heizhati Mulalibieke , Li Mei , Pan Fengyu , Yang Zhikang , Wang Zhongrong , Abudereyimu Reyila 
Published: January 2021

Abstract
Hypertensive patients commonly co-exist persistent depressive symptoms. However, these issues are not always identified, especially in primary health care, which may worsen the prognosis of hypertension. Therefore, the aim of this study was to determine the prevalence and risk factor of depression, and to develop risk nomogram of depression in hypertensive patients from primary health care Northwest China.
We used a stratified multistage random sampling method to obtain 1856 hypertensives subjects aged ≥18 years in Xinjiang between April and October 2019. The subjects were randomly divided into a training set (n = 1299) and a validation set (n = 557). Depression was evaluated by Hospital Anxiety and Depression Scale (HADS), with a cut-off score ≥8. Using the least absolute shrinkage and selection operator (LASSO) regression model, we identified optimized risk factors of depression in the training set, followed by the establishment of prediction nomogram. The discriminative ability, calibration, and clinical usefulness of nomogram were assessed. The results were verified by internal validation in validation set.
13.7% hypertensive subjects displayed depression. Seven independent risk factors of depression were identified and entered into the nomogram including age, region, ethnicity, marital status, physical activity, sleep quality, and control of hypertension. The nomogram displayed robust discrimination with an AUC of 0.760 [95% confidence interval (CI): 0.724–0.797)] and 0.761 (95%CI: 0.702–0.819), and good calibration in training set and validation set, respectively. The decision curve analysis and clinical impact curve demonstrated clinical usefulness of predictive nomogram.
There is a considerable prevalence of depression in patients with hypertension from primary care of Xinjiang, Northwest China. Our nomogram may help primary care providers assess the risk of depression in patients with hypertension.
Complementary and alternative therapies for non-alcoholic fatty liver disease
Authors: Zhang Tiefeng , Han Duan , Zhang Tianqi , Jing Cai , Sun Jianguang 
Published: January 2021

Abstract

Background:
Non-alcoholic fatty liver disease (NAFLD) has become a global pandemic, and its incidence is increasing year by year. At present, there are no definite curative drugs for the treatment of NAFLD in modern medicine. Surprisingly, complementary and alternative therapies play an important role and have special advantages. In this study, we will adopt Bayesian network meta-analysis (NMA) to evaluate the efficiency and safety of complementary therapy and alternative therapies for NAFLD.

Methods:
We will collect randomized controlled trials (RCTs) related to the treatment of NAFLD in PubMed, Cochrane Library, CNKI, and other databases. Two reviewers will screen the literature and extract data in line with the inclusion and exclusion criteria, and then assess the risk of bias according to Cochrane risk of bias assessment tool. The Bayesian NMA will be performed by Stata16.0 and WinBUGS1.4.3.

Results:
Our study will compare and rank the efficacy and safety of diverse complementary and alternative therapies for NAFLD.

Conclusion:
This study can provide credible evidence for the efficacy and safety of complementary therapies and alternative therapies in the treatment of NAFLD. We expect to assist clinicians and patients to choose the optimal therapeutic regimen.

Protocol registration number:
INPLASY2020120136.
Effects of Taijiquan on glucose and lipid metabolism in middle-aged and elderly diabetic patients
Authors: Liu Ya-Nv , Wang Lin , Fan Xin , Liu Shijie , Wu Qi , Qian You-Lin 
Published: January 2021

Abstract

Background:
The improvement effect of exercise on diabetes mellitus has been widely recognized. Taijiquan, as a popular exercise mode for middle-aged and elderly people, is not clear about its effect on glucose and lipid metabolism in elderly diabetic patients. In this paper, the influence of Taijiquan on glucose and lipid metabolism in middle-aged and elderly diabetic patients was studied by using a meta-analysis method, to provide evidence for the clinical promotion of Taijiquan to improve glucose and lipid metabolism in diabetic patients.

Methods:
Computer system search and manual search were conducted respectively in web of science, PubMed, Cochrane Library, EMBASE, Google Scholar, China National Knowledge Infrastructure, Wanfang Database, VIP from the inception to August 1, 2020. Randomized controlled trials of the application of Taijiquan in middle-aged and elderly diabetic patients were collected.

Results:
The current study is a systematic review and meta-analysis program with no results. Data analysis will be completed after the program.

Conclusion:
This review aims to study the effect of Taijiquan on the glucose and lipid metabolism of middle-aged and elderly diabetic patients, objectively evaluate the effect of Taijiquan on the glucose and lipid metabolism of middle-aged and elderly diabetic patients, and provide scientific basis for clinical exercise intervention in middle-aged and elderly diabetic patients.

Protocol registration number:
INPLASY2020120107
Comparison of clinical efficacy of laparoscopic splenectomy versus open splenectomy for idiopathic thrombocytopenic purpura
Authors: Zhu Quan-Li , Wu Wei 
Published: January 2021

Abstract

Background:
The purpose of this study is to compare the clinical efficacy of laparoscopic splenectomy (LS) and open splenectomy (OS) in the treatment of Idiopathic thrombocytopenic purpura.

Methods:
We systematically searched PubMed, Web of science, EMBASE, Clinicaltrials.gov, and Cochrane Central Register for studies (study published from July 1992–January 2020). This study analyzed the clinical effect of LS and OS on idiopathic thrombocytopenic purpur.

Results:
This study showed that compared with OS, the LS's Overall response (OR: 0.60, 95% confidence interval (CI): 0.23–1.59, P = .30), Complication (OR: 0.59, 95% CI: 0.18–1.94, P = .38), Accessory spleen(OR: 1.70, 95% CI: 0.98–2.98, P = .06), Wound infections (OR: 0.65, 95% CI: 0.26–1.59, P = .34), Pancreatic fistula (OR: 0.73, 95% CI: 0.16–3.30, P = .68), was no significant, the Operative time (weighted mean difference (WMD): 49.33, 95% CI: 36.29–62.37, P < .00001)was longer, and the Estimated blood loss (WMD: –172.59, 95% CI: –319.96 to –25.22, P = .02), Postoperative length of stay (WMD: –4.68, 95% CI: –7.75 to –1.62, P = .003)was less.

Conclusions:
The therapeutic effect of LS was the same as that of OS in Overall response Complication Accessory spleen, while The operative time was longer, the Estimated blood loss was less, and the postoperative length of stay was shorter.
Integrated Traditional Chinese and Western medicine for ulcerative colitis with diabetes
Authors: Lan Yu-Ze , Bai Ya-Li , Zhu Xiang-Dong 
Published: January 2021

Abstract

Background:
This study aimed to access the efficacy and safety of integrated Traditional Chinese and Western medicine treatment for patients with ulcerative colitis (UC) combined diabetes.

Methods:
This protocol adheres to the preferred reporting items for systematic reviews and meta-analysis protocol statement. We plan to search 8 electronic databases to identify qualifying studies published from database inception until December 1, 2020. The software of EndNote reference manager (X9) will be used to study selection. A pre-developed standardized data collection form will be used to extract from all eligible studies. For included studies, the quality will be assessed by Cochrane Risk of bias tool. The RevMan 5.3 software (Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014) developed by the Cochrane Collaboration will be used for all statistical analysis. If possible, meta-analysis will be undertaken for each of the outcomes. For continuous variable data, we will used mean differences with 95% confidence intervals (CIs) as summary statistics. For dichotomous variable data, we will calculate Mantel-Haenszel odds ratio with 95% CIs as summary statistics from the numbers of events in control and intervention groups. We will consider a result to be statistically significant if P < .05. If outcomes cannot be meta-analyzed, we will performer a descriptive analysis.

Results:
This study will be performed to test the efficacy and safety of integrated Traditional Chinese and Western medicine treatment for patients with UC combined diabetes.

Conclusion:
The results of our study will be published in a peer-reviewed journals, and we will promotion results in domestic and foreign conferences.

Registration number:
INPLASY2020120087

Ethics and dissemination:
As a systematic review and meta-analysis which based on previously published literature, ethical approval, and informed consent from patients are not required.
Effects of mind-body exercise on PTSD symptoms, depression and anxiety in PTSD patients
Authors: Zhu Lin , Li Long , Li Xiao-zhi , Wang Lin 
Published: January 2021

Abstract

Background:
The present study aimed to systematically analyze the effects of mind-body exercise on PTSD symptom, depression and anxiety among patients with post-traumatic stress disorder (PTSD) and to provide a scientific evidence-based exercise prescription. Meanwhile, it will also help reduce the global mental health burden of COVID-19.

Methods:
Both Chinese and English databases (PubMed, Web of Science, the Cochrane Library, EMBASE, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang) were used as sources of data to search for randomized controlled trials (RCTs) published between January 1980 to September 2020 relating to the effects of mind-body exercise on PTSD symptom, depression and anxiety in PTSD patients.

Conclusion:
This systematic review and meta-analysis will provide stronger evidence on the effectiveness and safety of mind-body exercise for PTSD symptoms in PTSD patients.

Systematic review registration:
INPLASY2020120072.
Severe laryngeal edema caused by Pseudoterranova species
Authors: Suzuki Shiori , Bandoh Nobuyuki , Goto Takashi , Uemura Akihiro , Sasaki Mizuki , Harabuchi Yasuaki 
Published: January 2021

Abstract

Rationale:
Severe laryngeal edema can cause upper airway obstruction, which is fatal. Pseudoterranova, an uncommon nematode of the family Anisakidae, predominantly invades the stomach after ingestion of the nematodes in raw or undercooked marine fish. There have been a few reports of development of severe laryngeal edema caused by the nematode invading the base of the tongue.

Patient concerns:
A 69-year-old Japanese woman complained of stuffy and scratchy throat for 8 hours and reported eating sashimi, fresh slices of raw jacopever, 4 days before the first visit.

Diagnosis:
Endoscopy revealed a white-yellowish wriggling worm at the left side of the base of the tongue and severe edema of the larynx.

Interventions:
The worm was extracted using endoscopic forceps. The patient was hospitalized and treated with intravenous injection of an antibiotic and steroid.

Outcomes:
The symptoms and laryngeal edema disappeared the next day. The worm was identified as a 4th-stage larva of Pseudoterranova spp based on morphologic features. The serum Anisakis-specific IgE antibody level was high, at 38.6 UA/mL.

Lessons:
Clinicians should be aware of the possibility of severe laryngeal edema due to invasion by anisakid nematodes in the pharyngolaryngeal area in cases involving previous ingestion of raw or uncooked marine fish.
Mixed response and mechanisms of resistance to larotrectinib in metastatic carcinoma ex pleomorphic adenoma of the parotid harboring an NTRK2 fusion
Authors: Pircher Magdalena , Briner Hans Rudolf , Bonomo Marco , Horcic Milo , Petrausch Ulf , Helbling Daniel , Winder Thomas 
Published: January 2021

Abstract

Introduction:
Standardized systemic treatment options are lacking for carcinoma ex pleomorphic adenoma, which is a rare and aggressive tumor primarily found in salivary glands.
Here we report the case of a 63-year-old male with carcinoma ex pleomorphic adenoma of the left parotid and parapharyngeal space harboring a neurotrophic receptor tyrosine kinase (NTRK) 2 fusion who was treated with a small molecule inhibitor that targets the tropomyosin receptor kinase (TRK) proteins. To the best of our knowledge, no similar case has been described in the literature so far.

Patient concerns:
After multiple surgical resections and radiotherapy for localized cancer disease over several years, our patient again developed an increasing swelling and pain around the left ear and numbness of the left half of the face.

Diagnosis:
Magnetic resonance imaging and positron emission tomography/computed tomography scans showed tumor recurrence in the left parotid, below the left ear, and in the parapharyngeal space, as well as metastases of the lungs and cervical lymph nodes. As data on the efficacy of systemic therapies for inoperable carcinoma ex pleomorphic adenoma are scarce, we performed a next-generation sequencing that revealed the presence of a hitherto unknown NTRK2 fusion.

Interventions:
Treatment with the TRK inhibitor larotrectinib was initiated, which induced rapid symptom improvement. However, part of the tumor had to be removed shortly afterwards due to local progression. Molecular testing did not demonstrate any alterations accounting for resistance to larotrectinib, with maintenance of the NTRK2 fusion.

Outcomes:
Three months later, imaging confirmed mixed response. While the reason for this remains unknown, the patient is in good condition and continues to receive larotrectinib.

Conclusion:
It remains unclear why our patient showed mixed response to larotrectinib and further studies are needed to explore other possible mechanisms of resistance.
Early-phase pelvic bone SPECT
Authors: Ayoubi Jacob , Guendouzen Sofiane , Morland David 
Published: January 2021

Abstract
Tomoscintigraphic reconstruction in nuclear medicine assumes that the distribution of the tracer is unchanged in the volume of interest throughout the duration of the acquisition. This condition is however not met in early-phase bone scintigraphy and early-phase pelvic SPECT may display helical artifacts due to the filling of the bladder. Those artifacts may hamper proper interpretation of surrounding bone areas. The aim of this study was to construct a 4D digital pelvic phantom to simulate different acquisition protocols and optimize the acquisition.
A 4D digital pelvic phantom was generated with a dynamic component consisting in an expanding bladder with 2 ureters and a static part consisting in the 2 kidneys, bone structures, and soft tissues. Projection data were obtained using an attenuated Radon transform function. Four acquisitions protocols were tested: 32 projections of 16 seconds (32–16–1), 32 projections of 8 seconds (32–8–1), 2 consecutive SPECT of 32 projections of 4 seconds (32–4–2) and 2 consecutive SPECT of 16 projections of 8 seconds (16–8–2). The optimal protocol was then tested on one patient.
The amplitude of the artifacts was reduced with the 32–8–1, 32–4–2, and 16–8–2 protocols. The 16–8–2 protocol had the highest signal to noise ratio among those 3 protocols. The bladder artifact was visually markedly reduced on the patient acquisition with a 16–8–2 protocol.
Two successive early-phase bone SPECT, with a lower number of projection than the usual protocol reduce the impact of the helical artifacts around the bladder.
The modified water swallowing test score is the best predictor of postoperative pneumonia following extubation in cardiovascular surgery
Authors: Oguchi Natsuko , Yamamoto Shuhei , Terashima Satsuki , Arai Ruka , Sato Masaaki , Ikegami Shota , Horiuchi Hiroshi 
Published: January 2021

Abstract
No guidelines have been established for the evaluation of swallowing function following extubation. The factors of bedside swallowing evaluations (BSEs) that are associated with the development of pneumonia have not been fully elucidated. This study aimed to retrospectively investigate the most appropriate measurements of BSEs for predicting pneumonia.
The study subjects were 97 adults who underwent BSEs following cardiovascular surgery. Patients were divided into the pneumonia onset group (n = 21) and the non-onset group (n = 76). Patient characteristics, intraoperative characteristics, complications, BSE results, and postoperative progress were compared between the groups. BSEs were composed of consciousness level, modified water swallowing test (MWST) score, repetitive saliva swallowing test score, speech intelligibility score, and risk of dysphagia in the cardiac surgery score. Univariate and multivariate analyses with the BSE as the independent variable and pneumonia onset as the dependent variable were also performed to identify factors that predict pneumonia. For factors that became significant in univariate analysis, the incidence of pneumonia was shown using the Kaplan-Meier curve.
No significant differences were found in patient characteristics, intraoperative characteristics, and complications between the 2 groups. The postoperative progress was significantly different between the 2 groups, the pneumonia-onset group had a significantly longer time until the start of oral intake and a significantly lower median value of Food Intake Level Scale at the time of discharge. According to univariate and multivariate analyses, MWST score was a significant factor for predicting the onset of pneumonia even after adjusting for patient characteristics and surgical factors, and the incidence of pneumonia increased approximately 3 times when the MWST score was 3 points or less.
The MWST score after extubation in cardiovascular surgery was the strongest predictor of postoperative pneumonia in BSEs. Furthermore, the incidence of pneumonia increased approximately 3 times when the MWST score was 3 points or less. Predicting cases with a high risk of developing pneumonia allows nurses and attending physicians to monitor the progress carefully and take aggressive preventive measures.
Clinical manifestation of multiple wasp stings with details of whole transcriptome analysis
Authors: Ou Wei-Fan , Huang Wei-Hsuan , Chiu Hsien-Fu , Mao Yan-Chiao , Wen Mei-Chin , Chen Cheng-Hsu , Hung Sheng-Jou , Wu Ming-Ju , Wu Chieh-Liang , Chao Wen-Cheng 
Published: January 2021

Abstract

Introduction:
Multiple wasp stings is an emergency result from systemic reactions to the toxin with a wide range of manifestations, and we presented 2 patients with distinct clinical and transcriptomic findings.

Patient concerns:
Two patients without systemic disease presented with nearly 90 painful papules after attacked by a swarm of wasps (Vespa basalis).

Diagnosis:
Patient 1 was a 44-year-old healthy male whose clinical manifestations mainly comprised hemolysis, hepatic injury, rhabdomyolysis, and acute kidney injury. Patient 2 was a 49-year-old healthy female who presented with severe acute respiratory distress syndrome (ARDS) in addition to certain clinical manifestations that were also found in patient 1. We used ribo- nucleic acid sequencing (RNA-Seq) to characterize the inflammatory responses of 2 patients with distinct clinical manifestations after multiple wasp stings.

Interventions:
Both 2 patients received 5 sessions of plasmapheresis, and patient-1 further received mechanical ventilation for 8 days as well as 8 sessions of hemodialysis until day 17.

Outcomes:
Both patients recovered uneventfully after the aforementioned management. We used RNA-Seq to demonstrate a largely regulated neutrophil-predominated immune response in patient 1. In patient 2, we found a profound neutrophilc response on week 1 and a robust neutrophilic as well as pro-inflammatory responses on week 2. Furthermore, we found increased expression of signals that were associated with renal system process on week 2.

Conclusion:
In conclusion, we report 2 patients who manifested with shared and distinct presentations after an attack by the same swarm of wasps. Both patients had hemolysis, rhabdomyolysis, hepatic injury and acute kidney injury, and 1 patient had ARDS. The whole transcriptomic analyses were consistent with the distinct clinical manifestation, and these results suggest the potential of RNA-Sequencing to disentangle complex inflammatory responses in patients with multiple wasp stings. Plasmapheresis and corticosteroid were administered to both patients and case 2 also underwent 8 sessions of hemodialysis.