bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence
Authors: Vierhout Megan , Ayoub Anmar , Naiel Safaa , Yazdanshenas Parichehr , Revill Spencer D. , Reihani Amir , Dvorkin‐Gheva Anna , Shi Wei , Ask Kjetil 
Published: June 2021

AbstractSince the discovery of the myofibroblast over 50 years ago, much has been learned about its role in wound healing and fibrosis. Its origin, however, remains controversial, with a number of progenitor cells being proposed. Macrophage–myofibroblast transition (MMT) is a recent term coined in 2014 that describes the mechanism through which macrophages, derived from circulating monocytes originating in the bone marrow, transformed into myofibroblasts and contributed to kidney fibrosis. Over the past years, several studies have confirmed the existence of MMT in various systems, suggesting that MMT could potentially occur in all fibrotic conditions and constitute a reasonable therapeutic target to prevent progressive fibrotic disease. In this perspective, we examined recent evidence supporting the notion of MMT in both human disease and experimental models across organ systems. Mechanistic insight from these studies and information from in vitro studies is provided. The findings substantiating plausible MMT showcased the co‐expression of macrophage and myofibroblast markers, including CD68 or F4/80 (macrophage) and α‐SMA (myofibroblast), in fibroblast‐like cells. Furthermore, fate‐mapping experiments in murine models exhibiting myeloid‐derived myofibroblasts in the tissue further provide direct evidence for MMT. Additionally, we provide some evidence from single cell RNA sequencing experiments confirmed by fluorescent in situ hybridisation studies, showing monocyte/macrophage and myofibroblast markers co‐expressed in lung tissue from patients with fibrotic lung disease. In conclusion, MMT is likely a significant contributor to myofibroblast formation in wound healing and fibrotic disease across organ systems. Circulating precursors including monocytes and the molecular mechanisms governing MMT could constitute valid targets and provide insight for the development of novel antifibrotic therapies; however, further understanding of these processes is warranted.
Alterations in arterial CO2 rather than pH affect the kinetics of neurovascular coupling in humans
Authors: Caldwell Hannah G. , Howe Connor A. , Hoiland Ryan L. , Carr Jay M.J.R. , Chalifoux Carter J. , Brown Courtney V. , Patrician Alexander , Tremblay Joshua C. , Panerai Ronney B. , Robinson Thompson G. , Minhas Jatinder S. , Ainslie Philip N. 
Published: June 2021

Key points
We investigated the influence of arterial () with and without acute experimental metabolic alkalosis on neurovascular coupling (NVC).
We assessed stepwise iso‐oxic alterations in prior to and following intravenous NaHCO3 to acutely elevate arterial pH and [HCO3–].
The NVC response was not altered following NaHCO3 between stepwise stages; therefore, NVC is acutely mediated by rather than the prevailing arterial [H+]/pH.
The NVC response was attenuated by 27–38% with −10 mmHg and the absolute peak change was reduced by −19% with +10 mmHg irrespective of acutely elevated arterial pH/[HCO3–].
The NVC kinetics (i.e. time to peak) were markedly slower with hypercapnia versus hypocapnia (24 ± 5 vs. 7 ± 5 s, respectively) likely indicating an influence of resting cerebrovascular tone on NVC responsiveness.
AbstractElevations in cerebral metabolism necessitate appropriate coordinated and localized increases in cerebral blood flow (i.e. neurovascular coupling; NVC). Recent pre‐clinical work indicates that arterial () mediates NVC independently of arterial/extracellular pH; this has yet to be experimentally tested in humans. The goal of this study was to investigate the hypotheses that: (1) the NVC response would be unaffected by acute experimentally elevated arterial pH; rather, would regulate any changes in NVC; and (2) stepwise respiratory alkalosis and acidosis would each progressively reduce the NVC response. Ten healthy males completed a standardized visual stimulus‐evoked NVC test during matched stepwise iso‐oxic alterations in (hypocapnia: −5, −10 mmHg; hypercapnia: +5, +10 mmHg) prior to and following intravenous NaHCO3 (8.4%, 50 mEq/50 ml) that elevated arterial pH (7.406 ± 0.019 vs. 7.457 ± 0.029; P < 0.001) and [HCO3–] (26.2 ± 1.5 vs. 29.3 ± 0.9 mEq/l; P < 0.001). Although the NVC response was collectively attenuated by 27–38% with −10 mmHg (stage post hoc: all P < 0.05), this response was unaltered following NaHCO3 (all P > 0.05) irrespective of the higher pH (P = 0.002) at each matched stage of (P = 0.417). The absolute peak change was reduced by −19 ± 41% with +10 mmHg irrespective of acutely elevated arterial pH/[HCO3–] (stage post hoc: P = 0.022). The NVC kinetics (i.e. time to peak) were markedly slower with hypercapnia versus hypocapnia (24 ± 5 vs. 7 ± 5 s, respectively; stage effect: P < 0.001). Overall, these findings indicate that temporal patterns in NVC are acutely regulated by rather than arterial pH per se in the setting of acute metabolic alkalosis in humans.
Application of the Buckingham Π Theorem to Model the Multiple Effect Vacuum Membrane Distillation
Authors: Najib A. , Orfi J. , Alansary H. , Ali E. 
Published: June 2021

Abstract
This study aims to develop a dimensionless model of the vacuum multi-effect membrane distillation (V-MEMD) system through which a preliminary prediction of the most critical performance indicators can be attained. The Buckingham Π theorem was utilized to define dimensionless parameters that enable the predicted relationships associated with independent input parameters to describe the essential performance indicators of the V-MEMD system. The obtained simplified model reduces the design parameters from ten to two effective dimensionless parameters to realize the realistic and actual behavior of the designated system. The self-sustained model can be used as a short-cut tool for design and performance analysis to avoid time-consuming experimentations and complicated theoretical models. The compatibility of the generated model is assessed by matching the expected response of the output dimensionless parameters of recovery ratio (Π6) and gain output ratio (GOR, Π12) to variations in the pressure ratio and cooling process. The model is validated with other works, and discrepancies are found to be within ±8% and ±0.8 for the recovery ratio and GOR, respectively. Furthermore, the specific thermal energy consumption (STEC) is correlated to the GOR assuming constant vaporization enthalpy and density of the distillate water. The correlation can predict STEC within 5% accuracy over various operating conditions for the supplied hot water.
Transient Channel Sagging Measurements Under Severe Thermal Loading Condition: An Optical Imaging Approach
Authors: Singh Ankit R. , Tariq Andallib 
Published: June 2021

Abstract
Whenever any engineering system comprising of an internally heated channel/tube is exposed to a severe thermal load, the sagging or deflection measurement becomes an inevitable task from its safety/design analysis perspective. As an example, in a horizontal-type nuclear reactor safety study, it is required to measure the sagging of the channels during a postulated accidental scenario analysis. Unfortunately, measurement of the transient deflection/sagging of the channel under a harsh environment at extreme temperatures is a challenging task, and cannot be performed by the means of conventional intrusive approaches. This study proposes a non-contact digital imaging method with a laser generator and bandwidth filter, which is tested to measure the continuous channel sagging in a uniquely designed test rig. A scaled-down channel setup simulating the horizontal type nuclear reactor is used during the implementation of the present approach for sagging analysis at elevated temperatures. A digital edge detection tool with the Canny method is used to extract digital edges from recorded grayscale images, wherein successive images are used to measure transient sagging. The results are compared with post-test channel deflection measurements, and the difference in measurement is found to be within ±10 percent of post-test deflection.
Computational Fluid Dynamics and Experimental Analysis of the Heat Transfer in a Room With a Roof Solar Chimney
Authors: Vazquez-Ruiz A. , Navarro J. M. A. , Hinojosa J. F. , Xamán J. P. 
Published: June 2021

Abstract
This study reports a numerical-experimental analysis of heat transfer and airflow in a scaled room with a heated wall coupled with a double-channel vertical roof solar chimney. For the experimental part, a parametric study was performed in the thermal system, considering different values of heat flux supplied to a vertical wall of the scaled room (75 and 150 W/m2) and the absorber surface of the solar chimney (151 and 667 W/m2). Experimental temperature profiles were obtained at six different depths and heights, and experimental heat transfer coefficients were computed for both heated surfaces. The renormalization group k-ɛ turbulence model was evaluated against experimental data using computational fluid dynamics software. With the validated model, the effect of the heated wall and solar chimney on temperature fields, flow patterns, and heat transfer convective coefficients are presented and discussed. The cases with heat flux on the heated wall of the scaled room produce the biggest air changes per hour (ACH), being 30.1, 31.2, and 23.4 ACH for cases 1 to 3, respectively, while cases with no heated wall produce fewer ACH (11.72 and 12.28 for case 4 and 5). The comparison between cases with and without heat flux on one vertical wall but the same solar chimney heat flux shows that the ACH increases between 154% and 156%, respectively.
Comparison of stress orientation indicators in Chicxulub’s peak ring: Kinked biotites, basal PDFs, and feather features
Authors: Ebert* M. , Poelchau M.H. , Kenkmann T. , Gulick S.P.S. , Hall B. , Lofi J. , McCall N. , Rae A.S.P. 
Published: June 2021

ABSTRACT
During hypervelocity impacts, target rocks are subjected to shock wave compression with high pressures and differential stresses. These differential stresses cause microscopic shear-induced deformation, which can be observed in the form of kinking, twinning, fracturing, and shear faulting in a range of minerals. The orientation of these shear-induced deformation features can be used to constrain the maximum shortening axis. Under the assumption of pure shear deformation, the maximum shortening axis is parallel to the maximum principal axis of stress, σ1, which gives the propagation direction of the shock wave that passed through a rock sample. In this study, shocked granitoids cored from the uppermost peak ring of the Chicxulub crater (International Ocean Discovery Program [IODP]/International Continental Drilling Project [ICDP] Expedition 364) were examined for structures formed by shearing. Orientations of kink planes in biotite and basal planar deformation features (PDFs) in quartz were measured with a U-stage and compared to a previous study of feather feature orientations in quartz from the same samples. In all three cases, the orientations of the shortening axis derived from these measurements were in good agreement with each other, indicating that the shear deformation features all formed in an environment with similar orientations of the maximum principal axis of stress. These structures formed by shearing are useful tools that can aid in understanding the deformational effects of the shock wave, as well as constraining shock wave propagation and postshock deformation during the cratering process.
A Method for Magma Viscosity Assessment by Lava Dome Morphology
Authors: Starodubtseva Yu. V. , Starodubtsev I. S. , Ismail-Zadeh A. T. , Tsepelev I. A. , Melnik O. E. , Korotkii A. I. 
Published: June 2021

AbstractLava domes form when a highly viscous magma erupts on the surface. Several types of lava dome morphology can be distinguished depending on the flow rate and the rheology of magma: obelisks, lava lobes, and endogenic structures. The viscosity of magma nonlinearly depends on the volume fraction of crystals and temperature. Here we present an approach to magma viscosity estimation based on a comparison of observed and simulated morphological forms of lava domes. We consider a two-dimensional axisymmetric model of magma extrusion on the surface and lava dome evolution, and assume that the lava viscosity depends only on the volume fraction of crystals. The crystallization is associated with a growth of the liquidus temperature due to the volatile loss from the magma, and it is determined by the characteristic time of crystal content growth (CCGT) and the discharge rate. Lava domes are modeled using a finite-volume method implemented in Ansys Fluent software for various CCGTs and volcanic vent sizes. For a selected eruption duration a set of morphological shapes of domes (shapes of the interface between lava dome and air) is obtained. Lava dome shapes modeled this way are compared with the observed shape of the lava dome (synthesized in the study by a random modification of one of the calculated shapes). To estimate magma viscosity, the deviation between the observed dome shape and the simulated dome shapes is assessed by three functionals: the symmetric difference, the peak signal-to-noise ratio, and the structural similarity index measure. These functionals are often used in the computer vision and in image processing. Although each functional allows to determine the best fit between the modeled and observed shapes of lava dome, the functional based on the structural similarity index measure performs it better. The viscosity of the observed dome can be then approximated by the viscosity of the modeled dome, which shape fits best the shape of the observed dome. This approach can be extended to three-dimensional case studies to restore the conditions of natural lava dome growth.
Nationwide multicentre comparison of preoperative biometry and predictability of cataract surgery in Japan
Authors: Kamiya Kazutaka , Hayashi Ken , Tanabe Mao , Tabuchi Hitoshi , Sato Masaki , Gotoh Norihito , Kojima Takashi , Hatsusaka Natsuko 
Published: June 2021

AimTo compare the preoperative biometric data and the refractive accuracy of cataract surgery among major surgical sites in a nationwide multicentre study.MethodsWe prospectively obtained the preoperative biometric data of 2143 eyes of 2143 consecutive patients undergoing standard cataract surgery at major 12 facilities and compared the preoperative biometry as well as the postoperative refractive accuracy among them.ResultsWe found significant differences in most preoperative variables, such as axial length (one-way analysis of variance, p=0.003), anterior chamber depth (p<0.001), lens thickness (p<0.001) and central corneal thickness (p<0.001), except for mean keratometry (p=0.587) and corneal astigmatism (p=0.304), among the 12 surgical sites. The prediction error using the Sanders-Retzlaff-Kraff/Theoretical (SRK/T formula was significantly more hyperopic than that using the Barrett Universal II formula (paired t-test, p<0.001). The absolute error using the SRK/T formula was significantly larger than that using the Barrett Universal II formula (p=0.016). The prediction error using the SRK/T formula was significantly more hyperopic than that using the Barrett Universal II formula at 10 of 12 institutions, but significantly more myopic at one institution. The absolute error using the SRK/T formula was significantly larger than that using the Barrett Universal II formula at 4 of 12 institutions but significantly smaller at two institutions.ConclusionsRegional divergences of the preoperative biometry were not necessarily negligible, and the optimised intraocular lens power calculation formula was individually different among the 12 facilities. Our findings highlight the importance of individual optimisation of these formulas at each facility, especially in consideration of these biometric variations.Trial registration numberClinical Trial Registry; 000039976.
Impact of free maternity policies in Kenya: an interrupted time-series analysis
Authors: Orangi Stacey , Kairu Angela , Malla Lucas , Ondera Joanne , Mbuthia Boniface , Ravishankar Nirmala , Barasa Edwine 
Published: June 2021

BackgroundUser fees have been reported to limit access to services and increase inequities. As a result, Kenya introduced a free maternity policy in all public facilities in 2013. Subsequently in 2017, the policy was revised to the Linda Mama programme to expand access to private sector, expand the benefit package and change its management.MethodsAn interrupted time-series analysis on facility deliveries, antenatal care (ANC) and postnatal care (PNC) visits data between 2012 and 2019 was used to determine the effect of the two free maternity policies. These data were from 5419 public and 305 private and faith-based facilities across all counties, with data sourced from the health information system. A segmented negative binomial regression with seasonality accounted for, was used to determine the level (immediate) effect and trend (month-on-month) effect of the policies.ResultsThe 2013 free-maternity policy led to a 19.6% and 28.9% level increase in normal deliveries and caesarean sections, respectively, in public facilities. There was also a 1.4% trend decrease in caesarean sections in public facilities. A level decrease followed by a trend increase in PNC visits was reported in public facilities. For private and faith-based facilities, there was a level decrease in caesarean sections and ANC visits followed by a trend increase in caeserean sections following the 2013 policy.Furthermore, the 2017 Linda Mama programme showed a level decrease then a trend increase in PNC visits and a 1.1% trend decrease in caesarean sections in public facilities. In private and faith-based facilities, there was a reported level decrease in normal deliveries and caesarean sections and a trend increase in caesarean sections.ConclusionThe free maternity policies show mixed effects in increasing access to maternal health services. Emphasis on other accessibility barriers and service delivery challenges alongside user fee removal policies should be addressed to realise maximum benefits in maternal health utilisation.
Indirect effects of 13-valent pneumococcal conjugate vaccine on pneumococcal carriage in children hospitalised with acute respiratory infection despite heterogeneous vaccine coverage: an observational study in Lao People’s Democratic Republic
Authors: Chan Jocelyn , Lai Jana Y R , Nguyen Cattram D , Vilivong Keoudomphone , Dunne Eileen M , Dubot-Pérès Audrey , Fox Kimberley , Hinds Jason , Moore Kerryn A , Nation Monica L , Pell Casey L , Xeuatvongsa Anonh , Vongsouvath Manivanh , Newton Paul N , Mulholland Kim , Satzke Catherine , Dance David A B , Russell Fiona M 
Published: June 2021

IntroductionEmpiric data on indirect (herd) effects of pneumococcal conjugate vaccines (PCVs) in settings with low or heterogeneous PCV coverage are limited. The indirect effects of PCV, which benefits both vaccinated and non-vaccinated individuals, are mediated by reductions in vaccine-type (VT) carriage (a prerequisite for disease). The aim of this study among hospitalised children in Lao People’s Democratic Republic (Lao PDR) is to determine the effectiveness of a 13-valent PCV (PCV13) against VT pneumococcal nasopharyngeal carriage (direct effects) and the association between village-level PCV13 coverage and VT carriage (indirect effects).MethodsPneumococcal nasopharyngeal carriage surveillance commenced in December 2013, shortly after PCV13 introduction (October 2013). We recruited and swabbed children aged 2–59 months admitted to hospital with acute respiratory infection. Pneumococci were detected usinglytAquantitative real-time PCR and serotyped using microarray. PCV13 status and village-level PCV13 coverage were determined using written immunisation records. Associations between both PCV13 status and village-level PCV13 coverage and VT carriage were calculated using generalised estimating equations, controlling for potential confounders.ResultsWe enrolled 1423 participants and determined PCV13 coverage for 368 villages (269 863 children aged under 5 years). By 2017, median village-level vaccine coverage reached 37.5%, however, the IQR indicated wide variation among villages (24.1–56.4). Both receipt of PCV13 and the level of PCV13 coverage were independently associated with a reduced odds of VT carriage: adjusted PCV13 effectiveness was 38.1% (95% CI 4.1% to 60.0%; p=0.032); and for each per cent increase in PCV13 coverage, the estimated odds of VT carriage decreased by 1.1% (95% CI 0.0% to 2.2%; p=0.056). After adjustment, VT carriage decreased from 20.0% to 12.8% as PCV13 coverage increased from zero to 60% among under 5.ConclusionsDespite marked heterogeneity in PCV13 coverage, we found evidence of indirect effects in Lao PDR. Individual vaccination with PCV13 was effective against VT carriage.
Cost and greenhouse gas emissions of current, healthy, flexitarian and vegan diets in Aotearoa (New Zealand)
Authors: Kidd Bruce , Mackay Sally , Vandevijvere Stefanie , Swinburn Boyd 
Published: June 2021

ObjectiveTo compare the costs and climate impact (greenhouse gas emissions) associated with current and healthy diets and two healthy and environmentally friendly dietary patterns: flexitarian and vegan.DesignModelling studySettingAotearoa (New Zealand).Main outcome measuresThe distribution of the cost and climate impact (kgCO2e/kg of food per fortnight) of 2 weekly current, healthy, vegan and flexitarian household diets was modelled using a list of commonly consumed foods, a set of quantity/serves constraints for each, and constraints for food group and nutrient intakes based on dietary guidelines (Eating and Activity Guidelines for healthy diets and EAT-Lancet reference diet for vegan and flexitarian diets) or nutrition survey data (current diets).ResultsThe iterative creation of 210–237 household dietary intakes for each dietary scenario was achieved using computer software adapted for the purpose (DIETCOST). There were stepwise differences between diet scenarios (p<0.001) with thecurrentdiet having the lowest mean cost in New Zealand Dollars (NZ$584 (95% CI NZ$580 to NZ$588)) per fortnight for a family of four) but highest mean climate impact (597 kgCO2e (95% CI 590 to 604 kgCO2e)), followed by the healthy diet (NZ$637 (95% CI NZ$632 to NZ$642), 452 kgCO2e (95% CI 446 to 458 kgCO2e)), the flexitarian diet (NZ$728 (95% CI NZ$723 to NZ$734), 263 kgCO2e (95% CI 261 to 265 kgCO2e)) and the vegan diet, which had the highest mean cost and lowest mean climate impact (NZ$789, (95% CI NZ$784 to NZ$794), 203 kgCO2e (95% CI 201 to 204 kgCO2e)). There was a negative relationship between cost and climate impact across diets and a positive relationship within diets.ConclusionsMoving from current diets towards sustainable healthy diets (SHDs) will reduce climate impact but generally at a higher cost to households. The results reflect trade-offs, with the larger constraints placed on diets, the greater cost and factors such as nutritional adequacy, variety, cost and low-emissions foods being considered. Further monitoring and policies are needed to support population transitions that are country specific from current diets to SHD.