bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Southern Ocean Exchange: porous boundaries between humpback whale breeding populations in southern polar waters
Authors: Marcondes M. C. C. , Cheeseman T. , Jackson J. A. , Friedlaender A. S. , Pallin L. , Olio M. , Wedekin L. L. , Daura-Jorge F. G. , Cardoso J. , Santos J. D. F. , Fortes R. C. , Araújo M. F. , Bassoi M. , Beaver V. , Bombosch A. , Clark C. W. , Denkinger J. , Boyle A. , Rasmussen K. , Savenko O. , Avila I. C. , Palacios D. M. , Kennedy A. S. , Sousa-Lima R. S. 
Published: December 2021

AbstractHumpback whales (Megaptera novaeangliae) are a cosmopolitan species and perform long annual migrations between low-latitude breeding areas and high-latitude feeding areas. Their breeding populations appear to be spatially and genetically segregated due to long-term, maternally inherited fidelity to natal breeding areas. In the Southern Hemisphere, some humpback whale breeding populations mix in Southern Ocean waters in summer, but very little movement between Pacific and Atlantic waters has been identified to date, suggesting these waters constituted an oceanic boundary between genetically distinct populations. Here, we present new evidence of summer co-occurrence in the West Antarctic Peninsula feeding area of two recovering humpback whale breeding populations from the Atlantic (Brazil) and Pacific (Central and South America). As humpback whale populations recover, observations like this point to the need to revise our perceptions of boundaries between stocks, particularly on high latitude feeding grounds. We suggest that this “Southern Ocean Exchange” may become more frequent as populations recover from commercial whaling and climate change modifies environmental dynamics and humpback whale prey availability.
Quantum imaging of a polarisation sensitive phase pattern with hyper-entangled photons
Authors: Kaur Manpreet , Singh Mandip 
Published: December 2021

AbstractA transparent polarisation sensitive phase pattern makes a polarisation dependent transformation of quantum state of photons without absorbing them. Such an invisible pattern can be imaged with quantum entangled photons by making joint quantum measurements on photons. This paper shows a long path experiment to quantum image a transparent polarisation sensitive phase pattern with hyper-entangled photon pairs involving momentum and polarisation degrees of freedom. In the imaging configuration, a single photon interacts with the pattern while the other photon, which has never interacted with the pattern, is measured jointly in a chosen polarisation basis and in a quantum superposition basis of its position which is equivalent to measure its momentum. Individual photons of each hyper-entangled pair cannot provide a complete image information. The image is constructed by measuring the polarisation state and position of the interacting photon corresponding to a measurement outcome of the non-interacting photon. This paper presents a detailed concept, theory and free space long path experiments on quantum imaging of polarisation sensitive phase patterns.
Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma
Authors: Liu Zhiwei , Sarathkumara Yomani D. , Chan John K. C. , Kwong Yok-Lam , Lam Tai Hing , Ip Dennis Kai Ming , Chiu Brian C.-H. , Xu Jun , Su Yu-Chieh , Proietti Carla , Cooper Martha M. , Yu Kelly J. , Bassig Bryan , Liang Raymond , Hu Wei , Ji Bu-Tian , Coghill Anna E. , Pfeiffer Ruth M. , Hildesheim Allan , Rothman Nathaniel , Doolan Denise L. , Lan Qing 
Published: December 2021

AbstractExtranodal natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy that has been etiologically linked to Epstein-Barr virus (EBV) infection, with EBV gene transcripts identified in almost all cases. However, the humoral immune response to EBV in NKTCL patients has not been well characterized. We examined the antibody response to EBV in plasma samples from 51 NKTCL cases and 154 controls from Hong Kong and Taiwan who were part of the multi-center, hospital-based AsiaLymph case–control study. The EBV-directed serological response was characterized using a protein microarray that measured IgG and IgA antibodies against 202 protein sequences representing the entire EBV proteome. We analyzed 157 IgG antibodies and 127 IgA antibodies that fulfilled quality control requirements. Associations between EBV serology and NKTCL status were disproportionately observed for IgG rather than IgA antibodies. Nine anti-EBV IgG responses were significantly elevated in NKTCL cases compared with controls and had ORshighest vs. lowest tertile > 6.0 (Bonferroni-corrected P-values < 0.05). Among these nine elevated IgG responses in NKTCL patients, three IgG antibodies (all targeting EBNA3A) are novel and have not been observed for other EBV-associated tumors of B-cell or epithelial origin. IgG antibodies against EBNA1, which have consistently been elevated in other EBV-associated tumors, were not elevated in NKTCL cases. We characterize the antibody response against EBV for patients with NKTCL and identify IgG antibody responses against six distinct EBV proteins. Our findings suggest distinct serologic patterns of this NK/T-cell lymphoma compared with other EBV-associated tumors of B-cell or epithelial origin.
Cross-bridge mechanics estimated from skeletal muscles’ work-loop responses to impacts in legged locomotion
Authors: Christensen Kasper B. , Günther Michael , Schmitt Syn , Siebert Tobias 
Published: December 2021

AbstractLegged locomotion has evolved as the most common form of terrestrial locomotion. When the leg makes contact with a solid surface, muscles absorb some of the shock-wave accelerations (impacts) that propagate through the body. We built a custom-made frame to which we fixated a rat (Rattus norvegicus, Wistar) muscle (m. gastrocnemius medialis and lateralis: GAS) for emulating an impact. We found that the fibre material of the muscle dissipates between 3.5 and $$23\,\upmu \hbox {J}$$

23

μ
J

ranging from fresh, fully active to passive muscle material, respectively. Accordingly, the corresponding dissipated energy in a half-sarcomere ranges between 10.4 and $$68\,z\hbox {J}$$

68

z
J

, respectively. At maximum activity, a single cross-bridge would, thus, dissipate 0.6% of the mechanical work available per ATP split per impact, and up to 16% energy in common, submaximal, activities. We also found the cross-bridge stiffness as low as $$2.2\,\hbox {pN}\,\hbox {nm}^{-1}$$

2.2

pN

nm

-
1

, which can be explained by the Coulomb-actuating cross-bridge part dominating the sarcomere stiffness. Results of the study provide a deeper understanding of contractile dynamics during early ground contact in bouncy gait.
Weakly Supervised Sensitive Heatmap framework to classify and localize diabetic retinopathy lesions
Authors: Al-Mukhtar Mohammed , Morad Ameer Hussein , Albadri Mustafa , Islam MD Samiul 
Published: December 2021

AbstractVision loss happens due to diabetic retinopathy (DR) in severe stages. Thus, an automatic detection method applied to diagnose DR in an earlier phase may help medical doctors to make better decisions. DR is considered one of the main risks, leading to blindness. Computer-Aided Diagnosis systems play an essential role in detecting features in fundus images. Fundus images may include blood vessels, exudates, micro-aneurysm, hemorrhages, and neovascularization. In this paper, our model combines automatic detection for the diabetic retinopathy classification with localization methods depending on weakly-supervised learning. The model has four stages; in stage one, various preprocessing techniques are applied to smooth the data set. In stage two, the network had gotten deeply to the optic disk segment for eliminating any exudate's false prediction because the exudates had the same color pixel as the optic disk. In stage three, the network is fed through training data to classify each label. Finally, the layers of the convolution neural network are re-edited, and used to localize the impact of DR on the patient's eye. The framework tackles the matching technique between two essential concepts where the classification problem depends on the supervised learning method. While the localization problem was obtained by the weakly supervised method. An additional layer known as weakly supervised sensitive heat map (WSSH) was added to detect the ROI of the lesion at a test accuracy of 98.65%, while comparing with Class Activation Map that involved weakly supervised technology achieved 0.954. The main purpose is to learn a representation that collect the central localization of discriminative features in a retina image. CNN-WSSH model is able to highlight decisive features in a single forward pass for getting the best detection of lesions.
Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy
Authors: Taguchi Shinya , Azushima Kengo , Yamaji Takahiro , Urate Shingo , Suzuki Toru , Abe Eriko , Tanaka Shohei , Tsukamoto Shunichiro , Kamimura Daisuke , Kinguchi Sho , Yamashita Akio , Wakui Hiromichi , Tamura Kouichi 
Published: December 2021

AbstractTumor necrosis factor (TNF)-α is a potent mediator of inflammation and is involved in the pathophysiology of chronic kidney disease (CKD). However, the effects of TNF-α inhibition on the progression of kidney fibrosis have not been fully elucidated. We examined the effects of TNF-α inhibition by etanercept (ETN) on kidney inflammation and fibrosis in mice with aristolochic acid (AA) nephropathy as a model of kidney fibrosis. C57BL/6 J mice were administered AA for 4 weeks, followed by a 4-week remodeling period. The mice exhibited kidney fibrosis, functional decline, and albuminuria concomitant with increases in renal mRNA expression of inflammation- and fibrosis-related genes. The 8-week ETN treatment partially but significantly attenuated kidney fibrosis and ameliorated albuminuria without affecting kidney function. These findings were accompanied by significant suppression of interleukin (IL)-1β, IL-6, and collagen types I and III mRNA expression. Moreover, ETN tended to reduce the AA-induced increase in interstitial TUNEL-positive cells with a significant reduction in Bax mRNA expression. Renal phosphorylated p38 MAPK was significantly upregulated by AA but was normalized by ETN. These findings indicate a substantial role for the TNF-α pathway in the pathogenesis of kidney fibrosis and suggest that TNF-α inhibition could become an adjunct therapeutic strategy for CKD with fibrosis.
Orangutan mothers adjust their behaviour during food solicitations in a way that likely facilitates feeding skill acquisition in their offspring
Authors: Mikeliban Mulati , Kunz Belinda , Rahmaeti Tri , Uomini Natalie , Schuppli Caroline 
Published: December 2021

AbstractImmature orangutans acquire their feeding skills over several years, via social and independent learning. So far, it has remained uninvestigated to what extent orangutan mothers are actively involved in this learning process. From a fitness point of view, it may be adaptive for mothers to facilitate their offspring’s skill acquisition to make them reach nutritional independence faster. Food solicitations are potential means to social learning which, because of their interactive nature, allow to investigate the degree of active involvement of the mother. To investigate the role of food solicitation and the role of the mother in immatures’ foraging skill acquisition, we analysed 1390 food solicitation events between 21 immature Sumatran orangutans (Pongo abelii) and their mothers, collected over 13 years at the Suaq Balimbing orangutan population. We found that solicitation rates decreased with increasing age of the immatures and increased with increasing processing complexity of the food item. Mothers were more likely to share complex items and showed the highest likelihoods of sharing around the age at which immatures are learning most of their feeding skills. Our results indicate that immature Sumatran orangutans use food solicitation to acquire feeding skills. Furthermore, mothers flexibly adjust their behaviour in a way that likely facilitates their offspring’s skill acquisition. We conclude that orangutan mothers have a more active role in the skill acquisition of their offspring than previously thought.
Very long term outcome after linear versus electrogram guided ablation for persistent atrial fibrillation
Authors: Yamashita Seigo , Tokuda Michifumi , Mahida Saagar , Sato Hidenori , Ikewaki Hirotsugu , Oseto Hirotsuna , Yokoyama Masaaki , Isogai Ryota , Tokutake Kenichi , Yokoyama Kenichi , Narui Ryohsuke , Kato Mika , Tanigawa Shin-ichi , Sugimoto Ken-ichi , Yoshimura Michihiro , Yamane Teiichi 
Published: December 2021

AbstractThe optimal ablation strategy for persistent atrial fibrillation (PsAF) remains to be defined. We sought to compare very long-term outcomes between linear ablation and electrogram (EGM)-guided ablation for PsAF. In a retrospective analysis, long-term arrhythmia-free survival compared between two propensity-score matched cohorts, one with pulmonary vein isolation (PVI) and linear ablation including roof/mitral isthmus line (LINE-group, n = 52) and one with PVI and EGM-guided ablation (EGM-group; n = 52). Overall, 99% of patients underwent successful PVI. Complete block following linear ablation was achieved for 94% of roof lines and 81% of mitral lines (both lines blocked in 75%). AF termination by EGM-guided ablation was accomplished in 40% of patients. Non-PV foci were targeted in 7 (13%) in the LINE-group and 5 (10%) patients in the EGM-group (p = 0.76). During 100 ± 28 months of follow-up, linear ablation was associated with superior arrhythmia-free survival after the initial and last procedure (1.8 ± 0.9 procedures) compared with EGM-group (Logrank test: p = 0.0001 and p = 0.045, respectively). In multivariable analysis, longer AF duration and EGM-guided ablation remained as independent predictors of atrial arrhythmia recurrence. Linear ablation might be a more effective complementary technique to PVI than EGM-guided ablation for PsAF ablation.
Magnetic field amplification driven by the gyro motion of charged particles
Authors: Gu Yan-Jun , Murakami Masakatsu 
Published: December 2021

AbstractSpontaneous magnetic field generation plays important role in laser-plasma interactions. Strong quasi-static magnetic fields affect the thermal conductivity and the plasma dynamics, particularly in the case of ultra intense laser where the magnetic part of Lorentz force becomes as significant as the electric part. Kinetic simulations of giga-gauss magnetic field amplification via a laser irradiated microtube structure reveal the dynamics of charged particle implosions and the mechanism of magnetic field growth. A giga-gauss magnetic field is generated and amplified with the opposite polarity to the seed magnetic field. The spot size of the field is comparable to the laser wavelength, and the lifetime is hundreds of femtoseconds. An analytical model is presented to explain the underlying physics. This study should aid in designing future experiments.
Machine learning to estimate the local quality of protein crystal structures
Authors: Miyaguchi Ikuko , Sato Miwa , Kashima Akiko , Nakagawa Hiroyuki , Kokabu Yuichi , Ma Biao , Matsumoto Shigeyuki , Tokuhisa Atsushi , Ohta Masateru , Ikeguchi Mitsunori 
Published: December 2021

AbstractLow-resolution electron density maps can pose a major obstacle in the determination and use of protein structures. Herein, we describe a novel method, called quality assessment based on an electron density map (QAEmap), which evaluates local protein structures determined by X-ray crystallography and could be applied to correct structural errors using low-resolution maps. QAEmap uses a three-dimensional deep convolutional neural network with electron density maps and their corresponding coordinates as input and predicts the correlation between the local structure and putative high-resolution experimental electron density map. This correlation could be used as a metric to modify the structure. Further, we propose that this method may be applied to evaluate ligand binding, which can be difficult to determine at low resolution.
Investigation of halloysite nanotubes and Schiff base combination with deposited copper iodide nanoparticles as a novel heterogeneous catalytic system
Authors: Daraie Mansoureh , Bagheri Donya , Malmir Masoume , Heravi Majid M. 
Published: December 2021

AbstractThe design, preparation and characterization of a novel composite based on functionalization of halloysite nanoclay with Schiff base followed by immobilization of copper iodide as nanoparticles is revealed. This novel nano composite was fully characterized by utilization of FTIR, SEM/EDX, TGA, XRD and BET techniques. This Cu(I) NPs immobilized onto halloysite was successfully examined as a heterogeneous, thus easily recoverable and reusable catalyst in one of classist organic name reaction so-called “Click Reaction”. That comprised a three component reaction of phenylacetylene, α-haloketone or alkyl halide and sodium azide in aqueous media to furnish 1,2,3‐triazoles in short reaction time and high yields. Remarkably, the examination of the reusability of the catalyst confirmed that the catalyst could be reused at least six reaction runs without appreciable loss of its catalytic activity.
Oxidative stress and soluble receptor for advanced glycation end-products play a role in the pathophysiology of delirium after cardiac surgery
Authors: Kaźmierski Jakub , Miler Piotr , Pawlak Agnieszka , Jerczyńska Hanna , Woźniak Joanna , Frankowska Emilia , Brzezińska Agnieszka , Nowakowska Karina , Woźniak Katarzyna , Krejca Michał , Wilczyński Mirosław 
Published: December 2021

AbstractCoronary-artery bypass graft (CABG) surgery is known to improve cardiac function and decrease mortality, albeit, this method of treatment is also associated with a neuropsychiatric complications including postoperative delirium. The pathophysiology of delirium after cardiac surgery remains poorly understood. Thus, the purpose of this study was to investigate whether oxidative stress reflected by decreased preoperative and postoperative plasma antioxidant activity is independently associated with delirium after cardiac surgery. The second aim was to assess whether decreased antioxidant activity is stress-related or mediated by other pathologies such as major depressive disorder (MDD), anxiety disorders, and cognitive impairment. Furthermore, the putative relationship between pre- and postoperative soluble receptor for advanced glycation end-products (sRAGE) overexpression and plasma antioxidant capacity was evaluated. The patients cognitive status was assessed 1 day preoperatively with the use of the Mini-Mental State Examination Test and the Clock Drawing Test. A diagnosis of MDD and anxiety disorders was established on the basis of DSM-5 criteria. Blood samples for antioxidant capacity and sRAGE levels were collected both preoperatively and postoperatively. The Confusion Assessment Method for the Intensive Care Unit was used within the first 5 days postoperatively to screen for a diagnosis of delirium. Postoperative delirium was diagnosed in 34% (61 of 177) of individuals. Multivariate logistic regression analysis revealed that low baseline antioxidant capacity was independently associated with postoperative delirium development. Moreover, increased risk of delirium was observed among patients with a preoperative diagnosis of MDD associated with antioxidant capacity decreased postoperatively. According to receiver operating characteristic analysis, the most optimal cutoff values of the preoperative and postoperative antioxidant capacity that predict the development of delirium were 1.72 mM and 1.89 mM, respectively. Pre- and postoperative antioxidant capacity levels were negatively correlated with postoperative sRAGE concentration (Spearman's Rank Correlation − 0.198 and − 0.158, p < 0.05, respectively). Patients with decreased preoperative antioxidant activity and those with depressive episodes complicated with lower postoperative antioxidant activity are at significantly higher risk of delirium after cardiac surgery development. sRAGE overexpression may be considered as protective mechanism against increased oxidative stress and subsequent cell damage.
Preclinical evaluation of noncontact vital signs monitoring using real-time IR-UWB radar and factors affecting its accuracy
Authors: Park Jun-Young , Lee Yonggu , Heo Ran , Park Hyun-Kyung , Cho Seok-Hyun , Cho Sung Ho , Lim Young-Hyo 
Published: December 2021

AbstractRecently, noncontact vital sign monitors have attracted attention because of issues related to the transmission of contagious diseases. We developed a real-time vital sign monitor using impulse-radio ultrawideband (IR-UWB) radar with embedded processors and software; we then evaluated its accuracy in measuring heart rate (HR) and respiratory rate (RR) and investigated the factors affecting the accuracy of the radar-based measurements. In 50 patients visiting a cardiology clinic, HR and RR were measured using IR-UWB radar simultaneously with electrocardiography and capnometry. All patients underwent HR and RR measurements in 2 postures—supine and sitting—for 2 min each. There was a high agreement between the RR measured using radar and capnometry (concordance correlation coefficient [CCC] 0.925 [0.919–0.926]; upper and lower limits of agreement [LOA], − 2.21 and 3.90 breaths/min). The HR measured using radar was also in close agreement with the value measured using electrocardiography (CCC 0.749 [0.738–0.760]; upper and lower LOA, − 12.78 and 15.04 beats/min). Linear mixed effect models showed that the sitting position and an HR < 70 bpm were associated with an increase in the absolute biases of the HR, whereas the sitting position and an RR < 18 breaths/min were associated with an increase in the absolute biases of the RR. The IR-UWB radar sensor with embedded processors and software can measure the RR and HR in real time with high precision. The sitting position and a low RR or HR were associated with the accuracy of RR and HR measurement, respectively, using IR-UWB radar.