bluuebunny/crossref_metadata_2025_split huggingface dataset:
A weighted least squares optimisation strategy for medical image super resolution via multiscale convolutional neural networks for healthcare applications
Authors: Goyal Bhawna , Lepcha Dawa Chyophel , Dogra Ayush , Wang Shui-Hua 
Published: July 2021

AbstractMedical imaging is an essential medical diagnosis system subsequently integrated with artificial intelligence for assistance in clinical diagnosis. The actual medical images acquired during the image capturing procedures generate poor quality images as a result of numerous physical restrictions of the imaging equipment and time constraints. Recently, medical image super-resolution (SR) has emerged as an indispensable research subject in the community of image processing to address such limitations. SR is a classical computer vision operation that attempts to restore a visually sharp high-resolution images from the degraded low-resolution images. In this study, an effective medical super-resolution approach based on weighted least squares optimisation via multiscale convolutional neural networks (CNNs) has been proposed for lesion localisation. The weighted least squares optimisation strategy that particularly is well-suited for progressively coarsening the original images and simultaneously extract multiscale information has been executed. Subsequently, a SR model by training CNNs based on wavelet analysis has been designed by carrying out wavelet decomposition of optimized images for multiscale representations. Then multiple CNNs have been trained separately to approximate the wavelet multiscale representations. The trained multiple convolutional neural networks characterize medical images in many directions and multiscale frequency bands, and thus facilitate image restoration subject to increased number of variations depicted in different dimensions and orientations. Finally, the trained CNNs regress wavelet multiscale representations from a LR medical images, followed by wavelet synthesis that forms a reconstructed HR medical image. The experimental performance indicates that the proposed model SR restoration approach achieve superior SR efficiency over existing comparative methods
Laboratory-Developed Tests: Design of a Regulatory Strategy in Compliance with the International State-of-the-Art and the Regulation (EU) 2017/746 (EU IVDR [In Vitro Diagnostic Medical Device Regulation])
Authors: Spitzenberger Folker , Patel Jaimin , Gebuhr Inga , Kruttwig Klaus , Safi Abdulrahim , Meisel Christian 
Published: July 2021

Abstract
Purpose
This study aimed at the development of a regulatory strategy for compliance of laboratory-developed tests (LDTs) with requirements of the Regulation (EU) 2017/746 (“EU-IVDR”) under consideration of international requirements for LDTs as established in major regulatory regions. Furthermore, it was analysed in how far elements of current LDT regulation could qualify for an internationally harmonised concept ensuring quality, safety and performance of LDTs.

Methods
A review of regulatory literature including legislation as well as guidance documents was performed. The regulatory strategy was adapted from international guidance concepts used for commercially marketed IVD. It was then applied to the example of a large medical laboratory in the EU. A high-level comparison was conducted to identify gaps and matches between the different international regulatory requirements for LDTs.

Results
A four-step strategy for compliance of LDTs with the EU IVDR was implemented in an exemplary medical laboratory. On the basis of an internationally used LDT definition, LDTs constitute nearly 50% of the total IVD devices used in the laboratory. While an ISO 15189-compliant QMS is a major component, it should be accompanied by the application of appropriate processes for risk management, performance evaluation and continuous monitoring of LDTs. At least six criteria represent common characteristics of a potential, internationally convergent concept for the regulation/standardization of LDTs.

Conclusions
This study confirms the impact of LDTs for individualized and innovative medical laboratory testing. Prerequisites for LDT use as especially given by the IVDR and missing interpretation in the EU with regard to the scope of LDT definition, the application of standards and the extent of documentation for LDTs currently lead to uncertainties for both laboratories and regulatory bodies responsible for LDT oversight. The characteristics identified as common criteria for ensuring quality, safety and performance of LDTs may be considered as central elements of future international consensus guidance.
Child maltreatment and protective assets in the development of internalising and externalising problems: A study of youth offenders
Authors: Li Dongdong , Ng Nyx , Chu Chi Meng , Oei Adam , Chng Grace , Ruby Kala 
Published: July 2021

ABSTRACTIntroductionAn emerging trend in child maltreatment research focuses on identifying protective assets that contribute to youth resilience. Extending the trend, this study examines not just whether but also how protective assets in various domains (e.g., the individual, family, and schools) are associated with internalising and externalising problems among youth offenders, which is a population that typically reports a high prevalence of child maltreatment experiences.MethodsThis study used the baseline data of 790 youth offenders (85% male) aged between 12 and 19 years old from the EPYC project, a national longitudinal study in Singapore. Structural equation modelling was conducted to test the direct effects and interactive effects of protective assets and child maltreatment on internalising and externalising problems.ResultsFor direct effects, maltreated youth offenders reported higher levels of internalising and externalising problems than their non‐maltreated counterparts. Higher levels of peer assets were directly related to lower levels of externalising, but not internalising problems. For interactive effects, overall protective assets, school/work assets and internal assets had significant buffering effects against physical/emotional abuse on externalising problems, whereas peer assets showed significant buffering effects against sexual abuse on internalising problems.ConclusionAn overall level of protective assets, as well as assets from specific domains (peer, school/work, and internal assets) could provide protective effects on problematic behaviours among youth offenders. Interventions seeking to address youth internalising and externalising problems should focus on reducing child maltreatment incidence and enhancing protective assets within these domains.
Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis
Authors: Ganesh Aravind , Reis Isabella R. , Varma Malavika , Patry David G. , Cooke Lara J. 
Published: July 2021

ABSTRACT:Background/Objective:Coronavirus disease 2019 (COVID-19) has been associated with various neurological and atypical head/eyes/ears/nose/throat (HEENT) manifestations. We sought to review the evidence for these manifestations.Methods:In this systematic review and meta-analysis, we compiled studies published until March 31, 2021 that examined non-respiratory HEENT, central, and peripheral nervous system presentations in COVID-19 patients. We included 477 studies for qualitative synthesis and 59 studies for meta-analyses.Results:Anosmia, ageusia, and conjunctivitis may precede typical upper/lower respiratory symptoms. Central nervous system (CNS) manifestations include stroke and encephalopathy, potentially with brainstem or cranial nerve involvement. MRI studies support CNS para-/postinfectious etiologies, but direct neuroinvasion seems very rare, with few cases detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the CNS. Peripheral nervous system (PNS) manifestations include muscle damage, Guillain–Barre syndrome (GBS), and its variants. There was moderate-to-high study heterogeneity and risk of bias. In random-effects meta-analyses, anosmia/ageusia was estimated to occur in 56% of COVID-19 patients (95% CI: 0.41–0.71, I2:99.9%), more commonly than in patients without COVID-19 (OR: 14.28, 95% CI: 8.39–24.29, I2: 49.0%). Neurological symptoms were estimated to occur in 36% of hospitalized patients (95% CI: 0.31–0.42, I2: 99.8%); ischemic stroke in 3% (95% CI: 0.03–0.04, I2: 99.2%), and GBS in 0.04% (0.033%–0.047%), more commonly than in patients without COVID-19 (OR[stroke]: 2.53, 95% CI: 1.16–5.50, I2: 76.4%; OR[GBS]: 3.43,1.15–10.25, I2: 89.1%).Conclusions:Current evidence is mostly from retrospective cohorts or series, largely in hospitalized or critically ill patients, not representative of typical community-dwelling patients. There remains a paucity of systematically gathered prospective data on neurological manifestations. Nevertheless, these findings support a high index of suspicion to identify HEENT/neurological presentations in patients with known COVID-19, and to test for COVID-19 in patients with such presentations at risk of infection.
Optimization of Man Power Deployment for Covid-19 Screening in a Tertiary Care Hospital: A Study of Utility of Queuing Analysis
Authors: Yadav Shakti Kumar , Singh Garima , Sarin Namrata , Singh Sompal , Gupta Ruchika 
Published: July 2021

AbstractObjectives:The recent Covid-19 pandemic has burdened the healthcare facilities, especially in the presence of limited infrastructure. We aimed at applying a queuing model to the Covid-19 screening area so as to optimize the screening services and ensuring that no patient is refused the service.Methods:The mean arrival time of patients, number of physicians, mean screening time and queue characteristics were observed and entered in the M/M/c/K queuing model using R programming to optimize the number of physicians required in the screening area.Results:Considering the mean arrival of 7 patients in 10 minutes and screening of 3 patients in 10 minutes by 1 physician, 2 physicians were assigned. At this capacity, the probability of saturation of the system was 15% with patient loss rate of 1.05 per 10 minutes. Queuing simulation with 3 physicians reduced the patient loss rate to 0.013 per 10 minutes and a saturation probability of 0.2%. However, an increase of arrival rate from 10 to 20 led to an early saturation of the system.Conclusion:Queuing models offer an opportunity for the healthcare providers and hospital administrators to optimize patient care services, especially in critical areas with an ever-changing situation such as the current pandemic.
Classification of backward filtrations and factor filtrations: examples from cellular automata
Authors: LANTHIER PAUL , DE LA RUE THIERRY 
Published: July 2021

AbstractWe consider backward filtrations generated by processes coming from deterministic and probabilistic cellular automata. We prove that these filtrations are standard in the classical sense of Vershik’s theory, but we also study them from another point of view that takes into account the measure-preserving action of the shift map, for which each sigma-algebra in the filtrations is invariant. This initiates what we call the dynamical classification of factor filtrations, and the examples we study show that this classification leads to different results.
How government-controlled media shifts policy attitudes through framing
Authors: Pan Jennifer , Shao Zijie , Xu Yiqing 
Published: July 2021

AbstractResearch shows that government-controlled media is an effective tool for authoritarian regimes to shape public opinion. Does government-controlled media remain effective when it is required to support changes in positions that autocrats take on issues? Existing theories do not provide a clear answer to this question, but we often observe authoritarian governments using government media to frame policies in new ways when significant changes in policy positions are required. By conducting an experiment that exposes respondents to government-controlled media—in the form of TV news segments—on issues where the regime substantially changed its policy positions, we find that by framing the same issue differently, government-controlled media moves respondents to adopt policy positions closer to the ones espoused by the regime regardless of individual predisposition. This result holds for domestic and foreign policy issues, for direct and composite measures of attitudes, and persists up to 48 hours after exposure.
Hypothesis testing with error correction models
Authors: Kraft Patrick W. , Key Ellen M. , Lebo Matthew J. 
Published: July 2021

AbstractGrant and Lebo (2016) and Keeleet al.(2016) clarify the conditions under which the popular general error correction model (GECM) can be used and interpreted easily: In a bivariate GECM the data must be integrated in order to rely on the error correction coefficient,$\alpha _1^\ast$, to test cointegration and measure the rate of error correction between a single exogenousxand a dependent variable,y. Here we demonstrate that even if the data are all integrated, the test on$\alpha _1^\ast$is misunderstood when there is more than a single independent variable. The null hypothesis is that there is no cointegration betweenyand anyxbut the correct alternative hypothesis is thatyis cointegrated with at least one—but not necessarily more than one—of thex's. A significant$\alpha _1^\ast$can occur when someI(1) regressors are not cointegrated and the equation is not balanced. Thus, the correct limiting distributions of the right-hand-side long-run coefficients may be unknown. We use simulations to demonstrate the problem and then discuss implications for applied examples.
Implementation strategies for improving vitamin D status and increasing vitamin D intake in the UK: current controversies and future perspectives: proceedings of the 2nd Rank Prize Funds Forum on vitamin D
Authors: Buttriss Judy L. , Lanham-New Susan A. , Steenson Simon , Levy Louis , Swan Gillian E. , Darling Andrea L. , Cashman Kevin D. , Allen Rachel E. , Durrant Louise R. , Smith Colin P. , Magee Pamela , Hill Tom R. , Uday Suma , Kiely Mairead , Delamare Gael , Hoyland Alexa E. , Larsen Lise , Street Laura N. , Mathers John C. , Prentice Ann 
Published: July 2021

AbstractA multi-disciplinary expert group met to discuss vitamin D deficiency in the UK and strategies for improving population intakes and status. Changes to UK Government advice since the 1st Rank Forum on Vitamin D (2009) were discussed, including rationale for setting a reference nutrient intake (10 µg/d; 400 IU/d) for adults and children (4+ years). Current UK data show inadequate intakes among all age groups and high prevalence of low vitamin D status among specific groups (e.g. pregnant women and adolescent males/females). Evidence of widespread deficiency within some minority ethnic groups, resulting in nutritional rickets (particularly among Black and South Asian infants), raised particular concern. Latest data indicate that UK population vitamin D intakes and status reamain relatively unchanged since Government recommendations changed in 2016. Vitamin D food fortification was discussed as a potential strategy to increase population intakes. Data from dose–response and dietary modelling studies indicate dairy products, bread, hens’ eggs and some meats as potential fortification vehicles. Vitamin D3appears more effective than vitamin D2for raising serum 25-hydroxyvitamin D concentration, which has implications for choice of fortificant. Other considerations for successful fortification strategies include: (i) need for ‘real-world’ cost information for use in modelling work; (ii) supportive food legislation; (iii) improved consumer and health professional understanding of vitamin D’s importance; (iv) clinical consequences of inadequate vitamin D status and (v) consistent communication of Government advice across health/social care professions, and via the food industry. These areas urgently require further research to enable universal improvement in vitamin D intakes and status in the UK population.
Sleep duration and eating behaviours are associated with body composition in 5-year-old children: findings from the ROLO longitudinal birth cohort study
Authors: Delahunt Anna , Conway Marie C. , McDonnell Ciara , O Reilly Sharleen L. , O Keeffe Linda M. , Kearney Patricia M. , Mehegan John , McAuliffe Fionnuala M. 
Published: July 2021

AbstractInadequate sleep and poor eating behaviours are associated with higher risk of childhood overweight and obesity. Less is known about the influence sleep has on eating behaviours and consequently body composition. Furthermore, whether associations differ in boys and girls has not been investigated extensively. We investigate associations between sleep, eating behaviours and body composition in cross-sectional analysis of 5-year-old children. Weight, height, BMI, mid upper arm circumference (MUAC), abdominal circumference (AC) and skinfold measurements were obtained. Maternal reported information on child’s eating behaviour and sleep habits were collected using validated questionnaires. Multiple linear regression examined associations between sleep, eating behaviours and body composition. Sleep duration was negatively associated with BMI, with 1-h greater sleep duration associated with 0·24 kg/m2 (B = 0·24, CI −0·42, −0·03, P = 0·026) lower BMI and 0·21 cm lower (B = –0·21, CI −0·41, −0·02, P = 0·035) MUAC. When stratified by sex, girls showed stronger inverse associations between sleep duration (h) and BMI (kg/m2) (B = –0·32; CI −0·60, −0·04, P = 0·024), MUAC (cm) (B = –0·29; CI −0·58, 0·000, P = 0·05) and AC (cm) (B = –1·10; CI −1·85, −0·21, P = 0·014) than boys. Positive associations for ‘Enjoys Food’ and ‘Food Responsiveness’ with BMI, MUAC and AC were observed in girls only. Inverse associations between sleep duration and ‘Emotional Undereating’ and ‘Food Fussiness’ were observed in both sexes, although stronger in boys. Sleep duration did not mediate the relationship between eating behaviours and BMI. Further exploration is required to understand how sleep impacts eating behaviours and consequently body composition and how sex influences this relationship.
Early-life exposure to the Chinese famine and risk of hyperuricaemia in adult females in Qingdao
Authors: Shao Yuhan , Liu Li , Li Xiaojing , Sun Jianping , Huang Xiaomei 
Published: July 2021

AbstractTwo population-based cross-sectional surveys involving randomly selected Chinese adults aged 35–74 years were conducted in Qingdao, China in 2006 and 2009. Nine thousand fifty-five subjects from the two surveys were grouped into four birth groups of fetal/infant exposed (born between 1 January 1959 and 31 December 1962), childhood exposed (born between 1 January 1950 and 31 December 1958), adolescence exposed (born between 1 January 1942 and 31 December 1949) and the unexposed (born before 1941 and after 1963). Multivariate logistic regression models were used to calculate the OR and 95 % CI of hyperuricaemia in different exposed groups. Overall, famine exposure in the fetal/infant period, childhood and adolescence was not associated with adulthood hyperuricaemia (all P > 0·05). In females, childhood exposed group (OR = 1·59, 95 % CI 1·25, 2·02) and adolescence exposed group (OR = 1·74, 95 % CI 1·30, 2·33) both had higher risks to have hyperuricaemia in adult. However, this difference was not found in fetal/infant exposed group. In males, no significant relation was observed in any famine exposed group (all P > 0·05). Exposure to famine in childhood and adolescence is associated with an increased risk of hyperuricaemia for adulthood of females, but not in males. Adequate nutrition during early life appears to be beneficial to prevent hyperuricaemia of adult females.
A NEW SOLUTION CONCERNING CHOICE-OF-LAW FOR THE ASSIGNMENT OF DEBTS
Authors: Xu Alison 
Published: July 2021

AbstractThis article explores a solution to the choice-of-law issues concerning both voluntary and involuntary assignments arising in a domestic forum. The focus is on English private international law rules relating to cross-border assignments. A distinction is made between primary and extended parties as the foundation for choice-of-law analysis. Drawing on insights from the distinction of the use value and exchange value of debts found in economics, this article proposes a new analytical framework for choice-of-law based on a modified choice-of-law theory of interest-analysis.
PORT CLOSURES AND PERSONS AT SEA IN INTERNATIONAL LAW
Authors: Galani Sofia 
Published: July 2021

AbstractThe systematic protection of persons at sea remains flawed. This problem has become even more acute during the Covid-19 pandemic when port closures have caused an unprecedented humanitarian crisis at sea. This article looks at the impact of port closures on the rights of persons at sea and considers how international law can protect those rights. While persons at sea are afforded significant rights protections in international law, the rights and duties of States often clash, with the result that persons at sea can find themselves in something of a legal vacuum. In order to address this problem, this article argues that the various rights and duties of States must be interpreted and applied in a way that fully recognises the rights of persons at sea.
Right to Development Governance in the Advent of the African Continental Free Trade Area
Authors: Ngang Carol Chi 
Published: July 2021

AbstractIn this article, I explore the question of whether the African Continental Free Trade Area (AfCFTA) could provide the framework mechanism for actualizing the right to development in Africa. The imperative for socio-economic and cultural development suggests rethinking the manner in which Africa is governed and, importantly, also the necessity of putting into place functional mechanisms in view of enacting the future that is envisaged for the continent. Article 22(2) of the African Charter enjoins state parties to individually or collectively undertake measures to give effect to the right to development. After several futile endeavours aimed at finding an appropriate mechanism for development, Africa eventually takes a giant stride in establishing the AfCFTA. From a decolonial perspective, I examine the prospects of the AfCFTA, particularly with regard to competing interests that dominate the African development space. At face value, the AfCFTA appears to provide an enabling framework for the nurturing of productive capabilities, the flourishing of local initiatives, the eradication of poverty and expanded opportunities for development. Notwithstanding, I contend that the inherently neoliberal nature of the AfCFTA leaves a further question of whether the free trade area is likely to deliver socio-economic and cultural development benefits to the peoples of Africa.
Re-evaluating the Admiralty Jurisdiction of Nigeria's Federal High Court in the Age of Combined Transport Shipping
Authors: Ukwueze Festus O , Umezuruike Herbert A , Ibegbulem Dike J 
Published: July 2021

AbstractThis article critically examines the admiralty jurisdiction of the Federal High Court of Nigeria in relation to claims arising from combined transport shipping. It questions the rationale for the continued circumscription of the court's admiralty jurisdiction to activities on navigable waters based on English law pedigree. It argues that, in the present era of containerization and combined transport shipping, it has become imperative to unshackle Nigerian courts from English antecedents that limit the admiralty jurisdiction of the court to activities on the high seas. The article identifies extant national legislation, a continental instrument and recent judicial authorities that provide the basis for expanding the Federal High Court's admiralty jurisdiction to accommodate the adjudication of claims derived from combined transport shipping beyond the locale of the high seas.