bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suppressive role of E3 ubiquitin ligase FBW7 in type I diabetes in non-obese diabetic mice through mediation of ubiquitination of EZH2
Authors: Guo Yingxue , Li Junfeng , Fan Shuang , Hu Qibo 
Published: November 2021

AbstractThe current study tried to uncover the molecular mechanism of E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (FBW7) in a heritable autoimmune disease, type I diabetes (T1D). After streptozotocin-induced T1D model establishment in non-obese diabetic (NOD) mouse, the protein expression of FBW7, enhancer of zeste homolog 2 (EZH2), and Zinc finger and BTB domain containing 16 (ZBTB16) was quantified. Next, splenocytes and pancreatic beta cells were isolated to measure the production of pro-inflammatory cytokines in splenocytes, as well as islet beta-cell apoptosis. Additionally, the stability of EZH2 induced by FBW7 was analyzed by cycloheximide chase assay. The binding affinity of FBW7 and EZH2 and the consequence of ubiquitination were monitored by co-immunoprecipitation assay. Last, a chromatin immunoprecipitation assay was employed to analyze the accumulation of EZH2 and H3K27me3 at the ZBTB16 promoter region. Our study demonstrated downregulated FBW7 and ZBTB16 and upregulated EZH2 in diabetic NOD mice. Overexpression of FBW7 in the NOD mice inhibited pro-inflammatory cytokine release in the splenocytes and the apoptosis of islets beta cells. FBW7 destabilized EZH2 and accelerated ubiquitin-dependent degradation. EZH2 and H3K27me3 downregulated the ZBTB16 expression by accumulating in the ZBTB16 promoter and methylation. FBW7 upregulates the expression of ZBTB16 by targeting histone methyltransferase EZH2 thus reducing the occurrence of T1D.
Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation
Authors: Pan Hong-Yu , Ye Zhi-Wei , Zheng Qian-Wang , Yun Fan , Tu Ming-Zhen , Hong Wei-Guo , Chen Bai-Xiong , Guo Li-Qiong , Lin Jun-Fang 
Published: November 2021

Postulated mechanisms of lifespan extension by EGT: preservation of CNS via the coordination of cholinergic neurotransmission, tyrosine metabolism, and peroxisomal proteins, regulated autophagic activity, and preservation of mitochondrial function.
A new periodic fractal parasitic structure to design the circularly polarized microstrip antenna for the satellite navigation system
Authors: Wei Kun , Wang Jun‐Long , Xu Rui , Ai Xia 
Published: November 2021

AbstractThis study presents a novel approach to design the single‐feed circularly polarized (CP) microstrip antenna by the periodic fractal parasitic structure (PFPS). By adding the PFPS along the radiated patch, a new independent orthogonal mode is generated. When the magnitudes of these two modes are the same and the time‐phase difference between them is 90°, the antenna can realise CP radiation. Parameter studies of the PFPS show how to design the CP microstrip antenna. The proposed CP microstrip antenna, designed for the satellite navigation system, has a 30 MHz 10‐dB impedance bandwidth and an 8 MHz 3‐dB axial ratio bandwidth in the centre frequency of 1.575 GHz. The advantage of this presented CP antenna is that these two modes for realising the CP radiation are independent of each other. This makes it more convenient to simplify the designing and debugging of the proposed CP antenna.
On the modelling, analysis, and design of a suboptimal controller for a class of wind/PV/battery based DC microgrid
Authors: Arabshahi Mohammad Reza , Torkaman Hossein , Bagheri Mehdi , Keyhani Ali 
Published: November 2021

AbstractThis study deals with the comprehensive modelling, analysis, and control of a DC microgrid (MG) in islanded mode. The proposed DC MG comprises a wind turbine, a photovoltaic (PV) source, battery storage, DC/DC source, and load side converters with DC loads. To this aim, a circuit‐oriented modelling of the whole system is developed. The PV source is modelled with a single‐diode electrical circuit. Afterward, a mathematical model of the system with state‐space representation was derived. A detailed analysis of PV system design is performed because the parameters of PV are appearing in the dynamic model of DC MG. For the purpose of controller development, the dynamic model of the DC MG, which is modelled by a non‐linear‐non‐affine eight‐order system, is linearized around an equilibrium point using the Jacobian matrix framework, while stability using eigenvalue is carried out showing that the stability is guaranteed under operating condition. Finally, for the first time, the state‐dependent Riccati equation (SDRE) technique is proposed to find the optimal regulation problem for the DC MG with non‐linear‐non‐affine dynamics. The numerical simulation studies first confirm the validity of the performed mathematical, then the effectiveness of the proposed non‐linear controller is evaluated under illumination and load change.
Detektion des subklinischen Keratokonus
Authors: Degle Stephan 
Published: November 2021

ZusammenfassungDas Frühstadium eines Keratokonus, ohne klassische und kennzeichnende klinische Befunde, stellt eine Kontraindikation für refraktive Chirurgie dar. Dieser Beitrag zeigt deshalb gemäß dem aktuellen Stand der Technik Möglichkeiten auf, Risikofaktoren für einen subklinischen Keratokonus zu erkennen.
Benigne Lidtumoren
Authors: Feldmann Maria Luisa , Chankiewitz Erik , Sonntag Svenja R. , Emmert Steffen , Ranjbar Mahdy , Grisanti Salvatore , Kakkassery Vinodh 
Published: November 2021

ZusammenfassungBenigne Lidtumoren sind vielfältig. In diesem Beitrag werden die häufigsten benignen Augenlidtumoren hinsichtlich Inzidenz, Klinik, Risikofaktoren, Symptomatik, histopathologischen Besonderheiten und Entartungs- sowie Rezidivwahrscheinlichkeit beleuchtet. Herausgearbeitet wird, wann eine systemische Abklärung erforderlich bzw. eine Probe zum Ausschluss eines Malignoms empfohlen ist und wie die Nachsorge auch im Hinblick auf eine spätere Entartung der Wucherung erfolgen sollte.
Neuroradiologie für den Augenarzt
Authors: Fitsiori Aikaterini , Steffen Heimo 
Published: November 2021

ZusammenfassungZu den neuroophthalmologischen Erkrankungen gehören Läsionen der Sehbahn einschließlich der Retina und des Sehnervs, Anomalien der Augenstellung und/oder -motilität sowie Pupillenstörungen 1. CT und MRT spielen bei der Diagnosestellung, der Ausbreitung eines Krankheitsprozesses und differenzialdiagnostischen Überlegungen eine herausragende Rolle. Ziel dieses Fortbildungsartikels ist es, dem Augenarzt einen Überblick über diese Untersuchungsverfahren und ihren Einsatz bei für den Augenarzt relevanten Erkrankungen zu geben.
Sind Prävalenzen in Survey- und Routinedaten vergleichbar?
Herzinfarktprävalenzen in Krankenkassendaten der AOK Niedersachsen und
in Daten der Studie zur Gesundheit Erwachsener in Deutschland
(DEGS1)
Authors: Epping Jelena , Safieddine Batoul , Geyer Siegfried , Tetzlaff Juliane 
Published: November 2021

Zusammenfassung
Ziele der Studie In dieser Studie wurde ein Vergleich von
Herzinfarktprävalenzen zwischen Krankenkassen- und
Gesundheitsbefragungsdaten vorgenommen. Bisherige Vergleichsstudien haben die
jeweilige Population verwendet, ohne mögliche Unterschiede in der
soziodemografischen Struktur zu berücksichtigen. Der hier verfolgte
Ansatz hatte zum Ziel, die soziodemografische Struktur über
verfügbare Informationen in beiden Datensätzen anzugleichen und
den Vergleich der Prävalenzen bei parallelisierten Stichproben
vorzunehmen.
Methodik Für die Analyse wurden die Daten der Studie zur
Gesundheit Erwachsener in Deutschland (DEGS1) und Abrechnungsdaten der AOK
Niedersachsen (AOKN) verwendet. Um die soziodemografische Struktur der beiden
Datensätze anzugleichen wurde eine nach Geschlecht, Alter und
Berufsbildungsabschluss parallelisierte Stichprobe aus den AOKN-Daten gezogen.
Im Rahmen einer Sensitivitätsanalyse wurden weitere Stichproben gezogen
und eine Gesamtprävalenz daraus gebildet.
Ergebnisse Es wurden Daten von 5779 DEGS1-Befragten und 22 534
AOKN-Versicherten für die Analyse verwendet. Nach der Parallelisierung
der Versichertenstichprobe nach Geschlecht, Alter und Berufsbildungsabschluss
ließen sich keine signifikanten Unterschiede in der
Herzinfarktprävalenz zwischen Krankenkassendaten der AOKN und Daten aus
dem Gesundheitssurvey DEGS1 feststellen. Bei Männern bestehen Tendenzen
zu niedrigeren Herzinfarktprävalenzen in den AOKN-Daten.
Mögliche Erklärung dafür ist entweder die vermutete
Selektion von weniger morbiden Versicherten durch die Verwendung des
Berufsbildungsabschlusses in den Daten der AOKN zur Parallelisierung oder aber
mögliche Erinnerungsfehler der Befragten in DEGS1.
Schlussfolgerung Für die Interpretation von
Erkrankungsprävalenzen aus unterschiedlichen Datenquellen können
Unterschiede in der soziodemografischen Struktur eine Rolle spielen. Dies kann
mittels Parallelisierung der Stichproben ausgeglichen werden. Künftige
vergleichende Analysen mit Routinedaten sollten verfügbare
soziodemografische Informationen berücksichtigen. Eine Ausweitung des
Ansatzes auf Krankheiten wie Diabetes und Stoffwechselstörungen ist in
Planung.
Erfassung der Verletztenversorgung in Krankenhausabrechnungsdaten:
Leistungen der BG Kliniken zu Lasten der Gesetzlichen
Unfallversicherung
Authors: Nimptsch Ulrike , Blümel Miriam , Topf Thomas , Stepath Kai , Busse Reinhard 
Published: November 2021

Zusammenfassung
Hintergrund Mit der Fallpauschalenbezogenen Krankenhausstatistik
(DRG-Statistik) verfügt Deutschland über ein nahezu
vollständiges Register aller akutstationären
Krankenhausbehandlungen. Behandlungen zu Lasten der gesetzlichen
Unfallversicherung, die in Krankenhäusern der Berufsgenossenschaften (BG
Kliniken) erbracht werden, sind jedoch von der von der Abrechnung nach dem
DRG-System und damit von der Datenübermittlungspflicht ausgenommen.
Daher ist davon auszugehen, dass die DRG-Statistik im Bereich der
Verletztenversorgung das stationäre Behandlungsaufkommen nicht
vollständig abbildet.
Methode Zur Abbildung der Versorgung von Verletzungen und
Verletzungsfolgen wurden Leistungsgruppen definiert, deren Fallzahlen sowohl in
den Mikrodaten der DRG-Statistik als auch in den Leistungsdaten aller neun BG
Kliniken berechnet wurden. Durch die Unterscheidung des Kostenträgers in
den Leistungsdaten der BG Kliniken (Gesetzliche Unfallversicherung vs. andere)
ließen sich die Schnittmenge der beiden Datenbestände sowie der
Anteil der nicht in der DRG-Statistik enthaltenen und damit nicht erfassten
Behandlungsfälle quantifizieren. Einbezogen wurden die Datenjahre 2016
bis 2018.
Ergebnisse Je nach Leistungsgruppe liegt die Untererfassung der
Behandlungsfälle in der DRG-Statistik kumuliert über die Jahre
2016 bis 2018 zwischen 0,1% und mehr als 60%. Die
größten Anteile der nicht in der DRG-Statistik erfassten
Behandlungsfälle betreffen die Frührehabilitation nach
Schädel-Hirn-Verletzungen (Untererfassung 61%), die Versorgung
von Querschnittverletzungen (Untererfassung 14% bei Erstversorgung,
23% bei Folgebehandlung), Amputationsverletzungen (Untererfassung
13%) und schwere Handverletzungen (Untererfassung 5%).
Schlussfolgerung Die Mikrodaten der DRG-Statistik sind in Bezug auf
Erkrankungen und Behandlungen, die nicht in die Leistungspflicht der
gesetzlichen Unfallversicherung fallen, als nahezu vollständig
anzusehen. In der Verletztenversorgung ergeben sich jedoch
größere Erfassungslücken durch die Versorgung in den BG
Kliniken zu Lasten der gesetzlichen Unfallversicherung. Eine
vollständige Abbildung der Verletztenversorgung ist nur unter
Einbeziehung der Leistungsdaten der BG Kliniken möglich.
Enantioselective, Copper-Catalyzed Addition of Nucleophilic Silicon to Alkenyl-Substituted Phosphine Oxides
Authors: Oestreich Martin , Hong Dou , Mao Wenbin , Irran Elisabeth 
Published: November 2021

AbstractAn enantioselective β-silylation of α,β-unsaturated phosphine oxide derivatives using a silylboronic ester as the silicon pronucleophile is reported. The reaction is catalyzed by copper salts in the presence of chiral pyridine–oxazoline (PyOx) ligands. Good to high enantioselectivities (≤95% ee) are obtained for β-aryl-substituted acceptors whereas alkyl residues in the β-position led to a lower ee value for 1° and no reaction for 2° and 3°. The new method represents another way of accessing α-chiral silanes and complements the known β-borylation.
The influence of waterproofing additives introduced into the mass of fresh concrete on the on the durability feature of the hardened concrete
Authors: Tuns I , Isopescu D N , Tamas F L , Boian I 
Published: November 2021

Abstract
The constructions with fluid retention and storage in general, between which the water holds a significant weight, are permanently exposed of physical and mechanical actions of deposited agent, with the continuous manifestation of the exfiltration tendency, herby the requirement of performance at tightness becomes essential. If the constructions that fulfill this role are realized of reinforced concrete, the tightness at fluid in general and at water in particular of the elements which compose the storage space is insured in a significant proportion by the waterproofing qualities of the structural concrete put in place. When the process of waterproofing concrete is clean and environmentally friendly and leads to improvement of initial physical-mechanical characteristics, represents an essential element in the combined approach of the performance requirements regarding the tightness and resistance condition. In this paper is presented a research study concerning the positive influence of waterproofing additive “Penetron” introduced into the fresh concrete mass used to realization of structural elements, with the role of storage and treatment of waste water, to mechanical characteristics of concrete after hardening.
On-board driver assistance systems classification
Authors: Khorychev A A 
Published: November 2021

Abstract
This article contains a brief overview of the known classifications of on-board driver assistance systems, the fundamental principles of a possible classification (based on a systematic approach and flow theory) and their application to systems of on-board driver assistance systems. The new classification criteria for the classification requirements is proposed for on-board driver assistance systems that take into account the peculiarities of the Russian Federation road network.
Wideband mid-infrared thermal emitter based on stacked nanocavity metasurfaces
Authors: Cao Tun , Lian Meng , Liu Kuan , Lou Xianchao , Guo Yaoming , Guo Dongming 
Published: November 2021

Abstract
Efficient thermal radiation in the mid-infrared (M-IR) region is of supreme importance for many applications including thermal imaging and sensing, thermal infrared light sources, infrared spectroscopy, emissivity coatings, and camouflage. The ability to control light makes metasurfaces an attractive platform for infrared applications. Recently, different metamaterials have been proposed to achieve high thermal radiation. To date, broadening the radiation bandwidth of a metasurface emitter (meta-emitter) has become a key goal to enable extensive applications. We experimentally demonstrate a broadband M-IR thermal emitter using stacked nanocavity metasurface consisting of two pairs of circular-shaped dielectric (Si3N4)–metal (Au) stacks. A high thermal radiation can be obtained by engineering the geometry of nanocavity metasurfaces. Such a meta-emitter provides wideband and broad angular absorptance of both p- and s-polarized light, offering a wideband thermal radiation with an average emissivity of more than 80% in the M-IR atmospheric window of 8–14 μm. The experimental illustration together with the theoretical framework establishes a basis for designing broadband thermal emitters, which, as anticipated, will initiate a promising avenue to M-IR sources.
American Literary Criticism in a Time of Pandemic
Authors: Constantinesco Thomas 
Published: November 2021

Abstract
This essay reflects, against the backdrop of the COVID-19 pandemic, on the relevance of literary studies in critical times, as well as on the notion of relevance as a measure of literary history and literary criticism. Drawing on the work of Giorgio Agamben and Wendy Brown, it argues for a model of relevance as untimeliness, where the function of criticism is to derive from literary texts a critical politics that eventually speaks both to these texts’ complex historical context and to their readers’ present and ever-changing circumstances. It then turns to the nineteenth-century archive to illustrate the untimely relevance of American literary history at the present time. While Dickinson might seem to suggest that “To suspend the breath/Is the most we can” (F1067) in a time of crisis, intimating that literature is essentially the record of our helplessness in the unraveling of the world, the example of Emerson’s antislavery lectures, where both the blight of slavery and the cause of abolition are metaphorized as airborne contamination, offer a template for thinking about the dangers as well as the potentialities of viral contagion.
American literature . . . captures the “air” or the atmosphere of history and equips us with models to take it in . . . Such is . . . [its] (un)timely relevance . . . at the present time.
spiralize: an R package for visualizing data on spirals
Authors: Gu Zuguang , Hübschmann Daniel 
Published: November 2021

Abstract

Summary
Spiral layout has two major advantages for data visualization. First, it is able to visualize data with long axes, which greatly improves the resolution of visualization. Second, it is efficient for time series data to reveal periodic patterns. Here, we present the R package spiralize that provides a general solution for visualizing data on spirals. spiralize implements numerous graphics functions so that self-defined high-level graphics can be easily implemented by users. The flexibility and power of spiralize are demonstrated by five examples from real-world datasets.

Availability and implementation
The spiralize package and documentations are freely available at the Comprehensive R Archive Network (CRAN) https://CRAN.R-project.org/package=spiralize

Supplementary information
Supplementary data are available at Bioinformatics online.
PIntMF: Penalized Integrative Matrix Factorization method for multi-omics data
Authors: Pierre-Jean Morgane , Mauger Florence , Deleuze Jean-François , Le Floch Edith 
Published: November 2021

AbstractMotivationIt is more and more common to perform multi-omics analyses to explore the genome at diverse levels and not only at a single level. Through integrative statistical methods, multi-omics data have the power to reveal new biological processes, potential biomarkers and subgroups in a cohort. Matrix factorization (MF) is an unsupervised statistical method that allows a clustering of individuals, but also reveals relevant omics variables from the various blocks.ResultsHere, we present PIntMF (Penalized Integrative Matrix Factorization), an MF model with sparsity, positivity and equality constraints. To induce sparsity in the model, we used a classical Lasso penalization on variable and individual matrices. For the matrix of samples, sparsity helps in the clustering, while normalization (matching an equality constraint) of inferred coefficients is added to improve interpretation. Moreover, we added an automatic tuning of the sparsity parameters using the famous glmnet package. We also proposed three criteria to help the user to choose the number of latent variables. PIntMF was compared with other state-of-the-art integrative methods including feature selection techniques in both synthetic and real data. PIntMF succeeds in finding relevant clusters as well as variables in two types of simulated data (correlated and uncorrelated). Next, PIntMF was applied to two real datasets (Diet and cancer), and it revealed interpretable clusters linked to available clinical data. Our method outperforms the existing ones on two criteria (clustering and variable selection). We show that PIntMF is an easy, fast and powerful tool to extract patterns and cluster samples from multi-omics data.Availability and implementationAn R package is available at https://github.com/mpierrejean/pintmf.Supplementary informationSupplementary data are available at Bioinformatics online.
Successive matings affect copulatory courtship but not sperm transfer in a spider model
Authors: Cargnelutti Franco , Calbacho-Rosa Lucia , Córdoba-Aguilar Alex , Peretti Alfredo Vicente 
Published: November 2021

Abstract
Previous studies have reported that males augment their reproductive success by increasing the number of females with which they copulate, and that such copulations are not energetically demanding in terms of trivial sperm production costs. However, we now know that males do pay reproductive costs. As males mate successively, a reduction in the performance of copulatory behaviours would be expected, as well as in the number of sperm transferred. Here we compared the duration of courtship, mating and post-insemination phase, the number of genital and non-genital copulatory courtship occurrences, and the number of sperm transferred in successive matings in Holocnemus pluchei spider males. As matings increased in males, there was no effect on the duration of courtship, mating or post-insemination phase. Interestingly, genital copulatory courtship varied in successive copulations depending on male size, but there was no change in the number of sperm transferred. In addition, the occurrence of non-genital copulatory courtship decreased along successive copulations. The negative effects of successive matings on copulatory courtship indicate that these behaviours are costly for males, except for the number of sperm transferred. Our research lays the foundation for future studies on male costs as a function of mating history in spiders.
Dissociating value-based neurocomputation from subsequent selection-related activations in human decision-making
Authors: Liu Zhiyuan , Liu Sijia , Li Shuang , Li Lin , Zheng Li , Weng Xue , Guo Xiuyan , Lu Yang , Men Weiwei , Gao Jiahong , You Xuqun 
Published: November 2021

AbstractHuman decision-making requires the brain to fulfill neural computation of benefit and risk and therewith a selection between options. It remains unclear how value-based neural computation and subsequent brain activity evolve to achieve a final decision and which process is modulated by irrational factors. We adopted a sequential risk-taking task that asked participants to successively decide whether to open a box with potential reward/punishment in an eight-box trial, or not to open. With time-resolved multivariate pattern analyses, we decoded electroencephalography and magnetoencephalography responses to two successive low- and high-risk boxes before open-box action. Referencing the specificity of decoding-accuracy peak to a first-stage processing completion, we set it as the demarcation and dissociated the neural time course of decision-making into valuation and selection stages. The behavioral hierarchical drift diffusion modeling confirmed different information processing in two stages, that is, the valuation stage was related to the drift rate of evidence accumulation, while the selection stage was related to the nondecision time spent in response-producing. We further observed that medial orbitofrontal cortex participated in the valuation stage, while superior frontal gyrus engaged in the selection stage of irrational open-box decisions. Afterward, we revealed that irrational factors influenced decision-making through the selection stage rather than the valuation stage.