bluuebunny/crossref_metadata_2025_split huggingface dataset:
An evaluation of PlayStreets in the South Side neighborhood of Columbus, Ohio
Authors: Adhikhari D , Henderson T , Dolce M , Banks AR , Zaim H , Onwuka A , Jones N 
Published: February 2021

Aims: Outdoor play, physical activity, and social cohesion are crucial indicators of community health. PlayStreets, a street play initiative to engage local children and families in outdoor play, physical activity, and social interactions, were implemented in a low-income neighborhood in Columbus, Ohio throughout the summer of 2019. This article aims to describe the implementation of a hospital-sponsored PlayStreets model executed through support from a community health initiative and to assess neighborhood impact through parent and child surveys. Methods: Approximately 350 children attended the events and 69 surveys were collected. Descriptive statistics were used to analyze survey data. Results: The mean age of children was 7 years, and the majority of children who attended were male. If not for PlayStreets, 55% of caregivers reported that their children would be inside. Event satisfaction levels were high, and 54% of caregivers said that they had more contact with their neighbors because of the events. Conclusions: Hospital buy-in and community support were crucial to the success of the event. We found that this model can successfully engage the local community while increasing opportunity for childhood outdoor play, physical activity, and neighborhood social interaction.
Substantial HbA1c Reduction Following Intermittent-Scanning Continuous Glucose Monitoring Was Not Associated With Early Worsening of Retinopathy in Type 1 Diabetes
Authors: Linton Kathryn , Stimson Roland H. , Dover Anna R. , Forbes Shareen , Madill Karen , Annoh Roxanne , Strachan Mark W. J. , McKnight J. A. , Wright Rohana J. , Gibb Fraser W. 
Published: February 2021

Background: Early worsening of diabetic retinopathy (EWDR) was observed in the intensively treated arm of the Diabetes Control and Complications Trial (DCCT) before long-term benefits accrued. We sought to assess whether there may be an increased risk of EWDR in high-risk individuals following intermittent-scanning continuous glucose monitoring (iscCGM) commencement. Methods: An observational study of 139 individuals with type 1 diabetes ≥5 years duration and with baseline HbA1c >75 mmol/mol (9.0%). This cohort was stratified by subsequent HbA1c response to iscCGM (best responders and non-responders). Pan-retinal photocoagulation (PRP), worsening retinopathy status and new development of retinopathy were compared between groups. Results: HbA1c change was -23 mmol/mol (IQR -32 to -19) (-2.1% [-2.9 to -1.8]) in responders and +6 mmol/mol (2-12) (+0.6 [0.2-1.1]) in non-responders ( P < .001). There was no difference in subsequent PRP between responders (14.1%) and non-responders (10.3%, P = .340). Baseline HbA1c (HR 1.052 per mmol/mol, P = .002) but not response category (HR 1.244, P = .664) was independently associated with the risk of requiring PRP. Worsening of retinopathy was not different between responders (16.9%) and non-responders (20.6%, P = .577), and the same was true with respect to new development of retinopathy (33.3% vs 31.8%, P = .919). Conclusions: In a cohort enriched for risk of diabetic retinopathy, reduction in HbA1c did not result in an increased risk of PRP, worsening retinopathy, or new development of retinopathy. These findings offer reassurance that substantial reduction in HbA1c is not independently associated with early worsening of diabetic eye disease in iscCGM users.
How to Define Pediatric Flatfoot: Comparison of 2 Methods: Foot Posture in Static and Dynamic Conditions in Children 5 to 9 Years Old
Authors: Boryczka-Trefler Anna , Kalinowska Małgorzata , Szczerbik Ewa , Stępowska Jolanta , Łukaszewska Anna , Syczewska Małgorzata 
Published: February 2021

Flexible flatfoot is the most common posture deformity among children. There are many diagnostic techniques to identify it, from clinical observation to measurements and imaging techniques, both in static and in dynamic conditions, but their reliability, validity, and accuracy are still unproven. The static and dynamic conditions differ; thus, the aim was to compare the results of the evaluation of flatfeet in 50 children (5-9 years of age) in both conditions: standing versus gait. Static evaluation. Comparison of the footprints (Harris and Beath pedograph) with the Clarke’s footprinting graphics. Dynamic evaluation. On the same day, all children underwent pedobarography during gait. Geometric measures of the feet (midfoot width, instep width, instep, foot width) were calculated together with the Arch Index. In the static condition, 87 of 100 were classified as a flatfoot, whereas during walking, there were just 56 feet classified as flat. So 35 feet classified on the basis of the clinical examination and Clarke’s footprint chart as flatfeet, according to the Arch Index calculated during walking were not flat, and 4 feet classified on the basis of Clarke’s footprint chart as normal according to the Arch Index were flat. Levels of Evidence: Prospective cohort study
The Brighton Spondylodiscitis Score Does Not Accurately Predict the Need for Surgery: A Retrospective Cohort Study in New Zealand
Authors: Hunter Sarah , Fernando Hasanga , Baker Joseph F. 
Published: February 2021

Study Design: Retrospective cohort study. Objectives: Despite pyogenic spondylodiscitis potentially conferring significant morbidity, there is no consensus on optimal treatment. The Brighton Spondylodiscitis Score (BSDS) was developed to identify patients who would likely fail conservative management and therefore benefit from earlier surgical intervention. In this study, we attempt external validation of the BSDS. Methods: We carried out a retrospective review of all patients treated at our institution, 2010-2016, for pyogenic spondylodiscitis. 91 met inclusion criteria and 40 progressed to require surgical intervention. The BSDS was calculated for each patient allowing stratification into low-, moderate- and high-risk groups. Calibration and discrimination was assessed with ROC curve analysis and calibration plot. Results: Area under the curve (AUC) was 0.469 (0.22-0.71) in our external validation, compared with AUC 0.83 and 0.71 (CI 0.50-0.88) in the original study and test populations respectively. Only 60% of patients in the high-risk group required surgery, 50% in the moderate, and 38% of the low indicating poor calibration and predictive accuracy. Operative intervention was not higher overall in our cohort (44% vs. 32%, p = 0.14). We found greater rates of bacteraemia, more distal infection, and more advanced MRI findings in our cohort. The incidence of spondylodiscitis in our region is higher (4/100 000/year). Conclusion: We failed to externally validate the BSDS in our population which is likely a result of unique population characteristics and the inherently variable pathology associated with spondylodiscitis. Clinicians must be cautious in adopting treatment algorithms developed in other health care systems that may comprise significantly different patient and pathogen characteristics.
Effect of shared decision making on mode of delivery and decisional conflict and regret in pregnant women with previous cesarean section: a randomized clinical trial
Authors: Hadizadeh-Talasaz Fatemeh , Ghoreyshi Faezeh , Mohammadzadeh Fatemeh , Rahmani Roghaieh 
Published: February 2021

Abstract
Background
The promotion of vaginal birth after cesarean section (VBAC) is the best method for the reduction of repeated cesarean sections. Nonetheless, the decisional conflict which often results from inadequate patient involvement in decision making, may lead to delayed decision making and regret about the choices that were made. The present study aimed to determine the effect of shared decision making on the mode of delivery and decisional conflict and regret in pregnant women with previous cesarean section.

Methods
This randomized clinical trial was conducted on 78 pregnant women with a previous cesarean section referring to community health centers in Torbat-e Jam, Iran, in 2019. They were randomly assigned to two groups of intervention and control. During weeks 24-30 of pregnancy, the Decisional Conflict Scale (DCS) was completed by pregnant mothers. Apart from the routine care, the experimental group received a counseling session which was held based on the three-talk model of shared decision making. This session was moderated by a midwife; moreover, a complementary counseling session was administered by a gynecologist. During weeks 35–37 of pregnancy, DCS was completed, and the Decision Regret Scale (DRS) was filled out for both groups at the 8th weeks postpartum and they were asked about the mode of delivery. Data were analyzed in SPSS software (version 19) using the Mann-Whitney, Chi-squared and Fisher’s exact tests. p-value less than 0.05 was considered statistically significant.

Results
After the intervention, the decisional conflict score was significantly lower in the shared decision making (SDM) group, compared to that in the control group (14.90 ± 9.65 vs. 25.41 ± 13.38; P < 0.001). Moreover, in the SDM group, the rate of vaginal birth was significantly higher than that in the control group (P < 0.001). Two month after the delivery, the mean score of decision regret was lower in the SDM group, in comparison to that in the control group (15.67 ± 23.37 vs. 27. 30± 26.75; P = 0.007).

Conclusions
Based on the results of the study, shared counseling can be effective in the reduction of decisional conflict and regret, as well as rate enhancement of VBAC. Therefore, it can be concluded that this counseling method can be used in prenatal care to reduce the rate of repeated cesarean section.

Trial registration
IRCT20190506043499N1; Name of the registry: Iranian Registry of Clinical Trials; Registered 10.
August 2019. URL of registry: https://en.irct.ir/trial/39538. Date of enrolment of the first participant to the trial: August 2019.
Effect of prior cancer on survival outcomes for patients with advanced prostate cancer
Authors: Wu Yechen , Chen Xi , Qian Duocheng , Wang Wei , Zhang Yiping , Hu Jinxin , Zhu Jun , Wu Qiang , Cao Tinghu 
Published: February 2021

Abstract
Background
A history of prior cancer commonly results in exclusion from cancer clinical trials. However, whether a prior cancer history has an adversely impact on clinical outcomes for patients with advanced prostate cancer (APC) remains largely unknown. We therefore aimed to investigate the impact of prior cancer history on these patients.

Methods
We identified patients with advanced prostate cancer diagnosed from 2004 to 2010 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance baseline characteristics. Kaplan–Meier method and the Cox proportional hazard model were utilized for survival analysis.

Results
A total of 19,772 eligible APC patients were included, of whom 887 (4.5 %) had a history of prior cancer. Urinary bladder (19 %), colon and cecum (16 %), melanoma of the skin (9 %) malignancies, and non-hodgkin lymphoma (9 %) were the most common types of prior cancer. Patients with a history of prior cancer had slightly inferior overall survival (OS) (AHR = 1.13; 95 % CI [1.02–1.26]; P = 0.017) as compared with that of patients without a prior cancer diagnosis. Subgroup analysis further indicated that a history of prior cancer didn’t adversely impact patients’ clinical outcomes, except in patients with a prior cancer diagnosed within 2 years, at advanced stage, or originating from specific sites, including bladder, colon and cecum, or lung and bronchus, or prior chronic lymphocytic leukemia.

Conclusions
A large proportion of APC patients with a prior cancer history had non-inferior survival to that of patients without a prior cancer diagnosis. These patients may be candidates for relevant cancer trials.
Belgian rare diseases plan in clinical pathology: identification of key biochemical diagnostic tests and establishment of reference laboratories and financing conditions
Authors:   Advisory Board of the Action 1 of the Belgian National Plan for Rare Diseases, Vandevelde Nathalie M. , Vermeersch Pieter , Devreese Katrien M. J. , Vincent Marie-Françoise , Gulbis Béatrice , Eyskens François , Boemer François , Gothot André , Van Hoof Viviane O. , Bonroy Carolien , Stepman Hedwig , Martens Geert A. , Bossuyt Xavier , Roosens Laurence , Smet Julie , Laeremans Hilde , Weets Ilse , Minon Jean-Marc , Vernelen Kris , Coucke Wim 
Published: February 2021

Abstract
Background
One objective of the Belgian Rare Diseases plan is to improve patients’ management using phenotypic tests and, more specifically, the access to those tests by identifying the biochemical analyses used for rare diseases, developing new financing conditions and establishing reference laboratories.

Methods
A feasibility study was performed from May 2015 until August 2016 in order to select the financeable biochemical analyses, and, among them, those that should be performed by reference laboratories. This selection was based on an inventory of analyses used for rare diseases and a survey addressed to the Belgian laboratories of clinical pathology (investigating the annual analytical costs, volumes, turnaround times and the tests unavailable in Belgium and outsourced abroad). A proposal of financeable analyses, financing modalities, reference laboratories’ scope and budget estimation was developed and submitted to the Belgian healthcare authorities. After its approval in December 2016, the implementation phase took place from January 2017 until December 2019.

Results
In 2019, new reimbursement conditions have been published for 46 analyses and eighteen reference laboratories have been recognized. Collaborations have also been developed with 5 foreign laboratories in order to organize the outsourcing and financing of 9 analyses unavailable in Belgium.

Conclusions
In the context of clinical pathology and rare diseases, this initiative enabled to identify unreimbursed analyses and to meet the most crucial financial needs. It also contributed to improve patients’ management by establishing Belgian reference laboratories and foreign referral laboratories for highly-specific analyses and a permanent surveillance, quality and financing framework for those tests.
Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion
Authors: Wu Xun , Cheng Yi-Shing Lisa , Matthen Mathew , Yoon Angela , Schwartz Gary K. , Bala Shashi , Taylor Alison M. , Momen-Heravi Fatemeh 
Published: February 2021

Abstract
Background
MicroRNAs (miRs) have been shown to play an important role in tumorigenesis, including in head and neck squamous cell carcinoma (HNSCC). The miR-34 family is thought to play a role in tumor suppression, but the exact mechanism of their action in HNSCC is not well understood. Moreover, the impact of chromosomal changes and mutation status on miR-34a expression remains unknown.

Methods
Differential expression of miR-34a, MET, and genomic alterations were assessed in the Cancer Genome Atlas (TCGA) datasets as well as in primary HNSCC and adjacent normal tissue. The biological functions of miR-34a in HNSCC were investigated in samples derived from primary human tumors and HNSCC cell lines. The expression of MET was evaluated using immunohistochemistry, and the molecular interaction of miR-34a and MET were demonstrated by RNA pulldown, RNA immunoprecipitation, luciferase reporter assay, and rescue experiments. Lastly, locked nucleic acid (LNA) miRs in mouse xenograft models were used to evaluate the clinical relevance of miR-34a in HNSCC tumor growth and modulation of the tumor microenvironment in vivo.

Results
Chromosome arm 1p loss and P53 mutations are both associated with lower levels of miR-34a. In HNSCC, miR-34a acts as a tumor suppressor and physically interacts with and functionally targets the proto-oncogene MET. Our studies found that miR-34a suppresses HNSCC carcinogenesis, at least in part, by downregulating MET, consequently inhibiting HNSCC proliferation. Consistent with these findings, administration of LNA-miR-34a in an in vivo model of HNSCC leads to diminished HNSCC cell proliferation and tumor burden in vitro and in vivo, represses expression of genes involved in epithelial-mesenchymal transition, and negates the oncogenic effect of MET in mouse tumors. Consistently, LNA-miR-34a induced a decreased number of immunosuppressive PDL1-expressing tumor-associated macrophages in the tumor microenvironment. In HNSCC patient samples, higher levels of miR-34a are significantly associated with a higher frequency of Th1 cells and CD8 naïve T cells.

Conclusions
Our results demonstrate that miR-34a directly targets MET and maintains anti-tumor immune activity. We propose miR-34a as a potential new therapeutic approach for HNSCC.
Incidence of urinary tract infection in neonates with significant indirect Hyperbilirubinemia of unknown etiology: case-control study
Authors: Baz Ahmed Mahrous Kamal , El-Agamy Osama Abd El-Fattah , Ibrahim Ashraf Mohamed 
Published: February 2021

Abstract
Background
Indirect hyperbilirubinemia is frequently encountered during neonatal period. Although it has different causes, in some cases it can’t be explained. Previous studies have illustrated that jaundice could be a major sign of urinary tract infection (UTI) in neonates.

Aim of the work
We aimed to determine the association between UTI and significant unexplained neonatal indirect hyperbilirubinemia.

Methods
This prospective controlled study was performed on 150 neonates divided in two groups (100 as cases and 50 as controls) to investigate the incidence of UTI in neonates with significant unexplained hyperbilirubinemia. Urine sample was obtained using urine catheterization technique from neonates and full urine analysis was done and cases with pyuria had urine culture to confirm UTI. Immediate renal ultrasonography (USG) was performed for neonates with UTI.

Results
UTI incidence was 11% in cases while none of neonates in control group had UTI with statistical significance between cases and controls (P value < 0.05). The most common (36.4%) pathogen was Escherichia coli. Posterior urethral valve with mild hydronephrosis was diagnosed in 18.2% of UTI positive patients by renal ultrasonography.

Conclusion
In neonates with unexplained indirect hyperbilirubinemia, UTI should be considered as a pathological cause.
Shear wave and strain sonoelastography for the evaluation of the Achilles tendon during isometric contractions
Authors: Schneebeli Alessandro , Fiorina Ilaria , Bortolotto Chandra , Barbero Marco , Falla Deborah , Cescon Corrado , Raciti Maria Vittoria , Tarantino Francesco , Preda Lorenzo 
Published: February 2021

Abstract
Objectives
Changes in mechanical loading as well as pathology can modify the Achilles tendon mechanical properties and therefore detection of these changes is relevant for the diagnosis and management of Achilles tendinopathy. The aim of this study was to evaluate strain and shear wave sonoelastography for their ability to detect changes in the Achilles tendon mechanical properties during a series of isometric contractions.

Methods
Longitudinal sonoelastography images of the Achilles tendon were acquired from 20 healthy participants using four different ultrasound devices; two implementing strain sonoelastography technology (SE1, SE2) and two, shear wave elastography technology (SWE1, SWE2).

Results
SE1 measured a decreasing strain ratio (tendon become harder) during the different contraction levels from 1.51 (0.92) to 0.33 (0.16) whereas SE2 mesaured a decreasing strain ratio from 1.08 (0.76) to 0.50 (0.32). SWE1 measured decreasing tendon stiffness during contractions of increasing intensity from 33.40 (19.61) to 16.19 (2.68) whereas SWE2 revealed increasing tendon stiffness between the first two contraction levels from 428.65 (131.5) kPa to 487.9 (121.5) kPa followed by decreasing stiffness for the higher contraction levels from 459.35 (113.48) kPa to 293.5 (91.18) kPa.

Conclusions
Strain elastography used with a reference material was able to detect elasticity changes between the different contraction levels whereas shear wave elastography was less able to detect changes in Achilles tendon stiffness when under load. Inconsistent results between the two technologies should be further investigated.
On statistical $\mathfrak{A}$-Cauchy and statistical $\mathfrak{A}$-summability via ideal
Authors: Edely Osama H. H. , Mursaleen M. 
Published: February 2021

AbstractThe notion of statistical convergence was extended to $\mathfrak{I}$
I
-convergence by (Kostyrko et al. in Real Anal. Exch. 26(2):669–686, 2000). In this paper we use such technique and introduce the notion of statistically $\mathfrak{A}^{\mathfrak{I}}$

A
I

-Cauchy and statistically $\mathfrak{A}^{\mathfrak{I}^{\ast }}$

A

I
∗

-Cauchy summability via the notion of ideal. We obtain some relations between them and prove that under certain conditions statistical $\mathfrak{A}^{\mathfrak{I}}$

A
I

-Cauchy and statistical $\mathfrak{A}^{\mathfrak{I}^{\ast }}$

A

I
∗

-Cauchy summability are equivalent. Moreover, we give some Tauberian theorems for statistical $\mathfrak{A}^{\mathfrak{I}}$

A
I

-summability.
Existence and global asymptotic stability criteria for nonlinear neutral-type neural networks involving multiple time delays using a quadratic-integral Lyapunov functional
Authors: Gholami Yousef 
Published: February 2021

AbstractIn this paper we consider a standard class of the neural networks and propose an investigation of the global asymptotic stability of these neural systems. The main aim of this investigation is to define a novel Lyapunov functional having quadratic-integral form and use it to reach a stability criterion for the under study neural networks. Since some fundamental characteristics, such as nonlinearity, including time-delays and neutrality, help us design a more realistic and applicable model of neural systems, we will use all of these factors in our neural dynamical systems. At the end, some numerical simulations are presented to illustrate the obtained stability criterion and show the essential role of the time-delays in appearance of the oscillations and stability in the neural networks.