bluuebunny/crossref_metadata_2025_split huggingface dataset:
Middle Miocene climate transition in the Tibetan Plateau: identification and significance
Authors: Song Shijun , Huang Lei , Zhang Yongshu , Zhang Qi , Zhou Fei , Liu Chiyang , Chen Yan , Wu Yingxiong , Zhang Yiming 
Published: October 2021

AbstractThe Middle Miocene Climatic Optimum is known for abrupt events during the global cooling trend of the past 20 Ma. Its identification in the Tibetan Plateau can help explain the cause of the critical Middle Miocene climate transition in Central Asia. In this study, fine-grained mixed sediments widely distributed in the Miocene Qaidam Lake in the northern Tibetan Plateau were used as a sensitive indicator for palaeoclimate. Their geochemical characteristics were investigated, together with an analysis of 2600 m long successive gamma-ray logging data from the whole JS2 drillcore, to understand the mid-Miocene climate transition in the Tibetan Plateau. By comparing the gamma-ray curve of the mixed sediments with global temperature, the Middle Miocene Climatic Optimum event can be easily identified. Further, the detailed petrological features and geochemical data of lacustrine fine-grained mixed sediments from a 400 m drillcore show oxidizing, high-sedimentation rate and brackish-saline water conditions in a semi-arid climate during the Middle Miocene period, demonstrating a dryer climate in the Qaidam Basin than in the monsoon-sensitive regions in Central Asia. These fine-grained mixed sediments have recorded climate drying before 15.3 Ma that represents a climatic transition within the Middle Miocene Climatic Optimum; increasing carbonate-rich mixed sediments, decreasing algal limestone layers and decreasing lacustrine organic matter are indicators of this transition. Regional tectonic events include the retreat of the Paratethys from Central Asia at ∼15 Ma and the synchronous tectonic reorganization of the Altyn-Tagh fault system and the northeastern Tibetan Plateau. We find that global climate change is the primary factor affecting the overall characteristics and changes of the Neogene climate in the Qaidam Basin, including the occurrence of the Middle Miocene Climatic Optimum and the cooling and drying tendency, while the regional events are a secondary factor.
Paediatric otogenic cerebral venous sinus thrombosis: a multidisciplinary approach
Authors: Constable J D , Hajioff D 
Published: October 2021

AbstractBackgroundPaediatric otogenic cerebral venous sinus thrombosis is a rare, heterogeneous and life-threatening condition, with possible otological, neurological and ophthalmological sequelae. Its course and outcomes can be widely variable. The publications available often consider individual aspects of paediatric otogenic cerebral venous sinus thrombosis management. The condition itself and the nature of the currently available guidance can lead to uncertainties when holistically managing patients with paediatric otogenic cerebral venous sinus thrombosis.ObjectivesClear recommendations for the comprehensive assessment and management of paediatric otogenic cerebral venous sinus thrombosis are presented, along with the literature review upon which they are based. Its clinical and radiological assessment are discussed.ConclusionA multidisciplinary approach to assessment and management is recommended, inclusive of infectious diseases, ENT surgery, neurology, ophthalmology and haematology. On balance, anticoagulation is recommended for three months. Follow-up imaging is not recommended in the absence of clinical concern. Follow up by ENT surgery, neurology and ophthalmology departments is recommended.
Reciprocal circulation pattern of SARS-CoV-2 and influenza viruses during the influenza seasons 2019/2020 and 2020/2021 in the Bavarian Influenza Sentinel (Germany)
Authors: Heinzinger Susanne , Eberle Ute , Angermeier Hildegard , Flechsler Jennifer , Konrad Regina , Dangel Alexandra , Berger Carola , Sprenger Annika , Hepner Sabrina , Biere Barbara , Liebl Bernhard , Ackermann Nikolaus , Sing Andreas 
Published: October 2021

Abstract
The corona virus disease-2019 (COVID-19) pandemic began in Wuhan, China, and quickly spread around the world. The pandemic overlapped with two consecutive influenza seasons (2019/2020 and 2020/2021). This provided the opportunity to study community circulation of influenza viruses and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in outpatients with acute respiratory infections during these two seasons within the Bavarian Influenza Sentinel (BIS) in Bavaria, Germany. From September to March, oropharyngeal swabs collected at BIS were analysed for influenza viruses and SARS-CoV-2 by real-time polymerase chain reaction. In BIS 2019/2020, 1376 swabs were tested for influenza viruses. The average positive rate was 37.6%, with a maximum of over 60% (in January). The predominant influenza viruses were Influenza A(H1N1)pdm09 (n = 202), Influenza A(H3N2) (n = 144) and Influenza B Victoria lineage (n = 129). In all, 610 of these BIS swabs contained sufficient material to retrospectively test for SARS-CoV-2. SARS-CoV-2 RNA was not detectable in any of these swabs. In BIS 2020/2021, 470 swabs were tested for influenza viruses and 457 for SARS-CoV-2. Only three swabs (0.6%) were positive for Influenza, while SARS-CoV-2 was found in 30 swabs (6.6%). We showed that no circulation of SARS-CoV-2 was detectable in BIS during the 2019/2020 influenza season, while virtually no influenza viruses were found in BIS 2020/2021 during the COVID-19 pandemic.
Closing lower secondary schools had no impact on COVID-19 incidence in 13–15-year-olds in Finland
Authors: Juutinen Aapo , Sarvikivi Emmi , Laukkanen-Nevala Päivi , Helve Otto 
Published: October 2021

Abstract
School lockdowns have been widely used to control the COVID-19 pandemic. However, these lockdowns may have a significant negative impact on the lives of young people. In this study, we have evaluated the impact of closing lower secondary schools for COVID-19 incidence in 13–15-year-olds in Finland, in a situation where restrictions and recommendation of social distancing were implemented uniformly in the entire country. COVID-19 case numbers were obtained from the National Infectious Disease Registry (NIDR) of the Finnish Institute for Health and Welfare, in which clinical microbiology laboratories report all positive SARS-CoV-2 tests with unique identifiers in a timely manner. The NIDR is linked to population data registry, enabling calculation of incidences. We estimated the differences in trends between areas with both restaurant and lower secondary school closures and areas with only restaurant closures in different age groups by using joinpoint regression. We also estimated the differences in trends between age groups. Based on our analysis, closing lower secondary schools had no impact on COVID-19 incidence among 13–15-year-olds. No significant changes on COVID-19 incidence were observed in other age groups either.
The phenotypic associations and gene–environment underpinnings of socioeconomic status and diurnal cortisol secretion in adolescence
Authors: Cantave Christina Y. , Brendgen Mara , Paquin Stéphane , Lupien Sonia , Dionne Ginette , Vitaro Frank , Boivin Michel , Ouellet-Morin Isabelle 
Published: October 2021

AbstractWhile converging evidence suggests that both environmental and genetic factors underlie variations in diurnal cortisol, the extent to which these sources of influence vary according to socioeconomic status (SES) has seldom been investigated, particularly in adolescence. To investigate whether a distinct genetic and environmental contribution to youth’s diurnal cortisol secretion emerges according to family SES and whether the timing of these experiences matters. Participants were 592 twin pairs, who mostly came from middle-income and intact families and for whom SES was measured in childhood and adolescence. Diurnal cortisol was assessed at age 14 at awakening, 30 min later, in the afternoon and evening over four nonconsecutive days. SES–cortisol phenotypic associations were specific to the adolescence period. Specifically, higher awakening cortisol levels were detected in wealthier backgrounds, whereas higher cortisol awakening response (CAR) and diurnal changes were present at both ends of the SES continuum. Moreover, smaller genetic contributions emerged for awakening cortisol in youth from poorer compared to wealthier backgrounds. The results suggest that the relative contribution of inherited factors to awakening cortisol secretion may be enhanced or suppressed depending on the socio-family context, which may help to decipher the mechanisms underlying later adjustment.
How Will Baseflow Respond to Climate Change in the Upper Colorado River Basin?
Authors: Miller Olivia L. , Miller Matthew P. , Longley Patrick C. , Alder Jay R. , Bearup Lindsay A. , Pruitt Tom , Jones Daniel K. , Putman Annie L. , Rumsey Christine A. , McKinney Tim 
Published: October 2021

AbstractBaseflow is critical to sustaining streamflow in the Upper Colorado River Basin. Therefore, effective water resources management requires estimates of baseflow response to climatic changes. This study provides the first estimates of projected baseflow changes from historical (1984–2012) to thirty‐year periods centered around 2030, 2050, and 2080 under warm/wet, median, and hot/dry climatic conditions using a hybrid statistical‐deterministic baseflow model. Total baseflow supplied to the Lower Colorado River Basin may decline by up to 33%, although this value may increase in the near future by 6% under warm/wet conditions. The percentage of baseflow lost during in‐stream transport is projected to increase by 1%–5% relative to historical conditions. Results highlight that climate‐driven changes in high‐elevation hydrology have impacts on basinwide water availability. Study results have implications for human and ecological water availability in one of the most heavily managed watersheds in the world.
Seasonal Variability of the Daytime and Nighttime Atmospheric Turbulence Experienced by InSight on Mars
Authors: Chatain A. , Spiga A. , Banfield D. , Forget F. , Murdoch N. 
Published: October 2021

AbstractThe InSight mission, featuring continuous high‐frequency high‐sensitivity pressure measurements, is in ideal position to study the active atmospheric turbulence of Mars. Data acquired during 1.25 Martian year allows us to study the seasonal evolution of turbulence and its diurnal cycle. We investigate vortices (abrupt pressure drops), local turbulence (frequency range Hz) and non‐local turbulence often caused by convection cells and plumes (frequency range Hz). Contrary to non‐local turbulence, local turbulence is strongly sensitive at all local times and seasons to the ambient wind. We report many remarkable events with the arrival of northern autumn at the InSight landing site: a spectacular burst of daytime vortices, the appearance of nighttime vortices, and the development of nighttime local turbulence as intense as its daytime counterpart. Nighttime turbulence at this dusty season appears as a result of the combination of a stronger low‐level jet, producing shear‐driven turbulence, and a weaker stability.
Contribution of Recycled Moisture to Precipitation: A Modified D‐Excess‐Based Model
Authors: Zhang Fen , Huang Tianming , Man Wenmin , Hu Hongchang , Long Yin , Li Zhenbin , Pang Zhonghe 
Published: October 2021

AbstractDefining moisture sources and evolution of precipitation is of significance for further exploration of complex hydro‐climatic interactions, especially under global warming with alternations of evapotranspiration capacity and precipitation moisture source structure. As a sensitive indicator, d‐excess has been widely used to quantify the proportion of recycled vapor to precipitation (fre). However, existing d‐excess‐based models ignore to take transpiration vapor into account and the calculated fre tends to be lower than the true value, thus underestimating the importance of recycled vapor in precipitation. Herein, the existing model was modified with transpiration vapor considered and applied in Guyuan, China located in a monsoon marginal zone with complex precipitation moisture sources. After modification, the estimated annual average fre was increased from 7.5% to 14.8%, well calibrating the existing model. This study highlights the contribution of transpiration vapor to precipitation and provides more information on the formation and evolution of precipitation to better serve future hydro‐climatic research.
Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency
Authors: Tsai Yi-Chih , Chen Su-Liang , Peng Shu-Ling , Tsai Ya-Li , Chang Zuong-Ming , Chang Vincent Hung-Shu , Ch’ang Hui-Ju 
Published: October 2021

AbstractKrüppel-like factor 10 (KLF10) is a tumor suppressor in multiple cancers. In a murine model of spontaneous pancreatic adenocarcinoma (PDAC), additional KLF10 depletion accelerated distant metastasis. However, Klf10 knockout mice, which suffer from metabolic disorders, do not develop malignancy. The mechanisms of KLF10 in PDAC progression deserve further exploration. KLF10-depleted and KLF10-overexpressing PDAC cells were established to measure epithelial-mesenchymal transition (EMT), glycolysis, and migration ability. A murine model was established to evaluate the benefit of genetic or pharmacological manipulation in KLF10-depleted PDAC cells (PDACshKLF10). Correlations of KLF10 deficiency with rapid metastasis, elevated EMT, and glycolysis were demonstrated in resected PDAC tissues, in vitro assays, and murine models. We identified sirtuin 6 (SIRT6) as an essential mediator of KLF10 that modulates EMT and glucose homeostasis. Overexpressing SIRT6 reversed the migratory and glycolytic phenotypes of PDACshKLF10 cells. Linoleic acid, a polyunsaturated essential fatty acid, upregulated SIRT6 and prolonged the survival of mice injected with PDACshKLF10. Modulating HIF1α and NFκB revealed that EMT and glycolysis in PDAC cells were coordinately regulated upstream by KLF10/SIRT6 signaling. Our study demonstrated a novel KLF10/SIRT6 pathway that modulated EMT and glycolysis coordinately via NFκB and HIF1α. Activation of KLF10/SIRT6 signaling ameliorated the distant progression of PDAC.Clinical Trial Registration:ClinicalTrials.gov. identifier: NCT01666184.
The current status of risk-stratified breast screening
Authors: Clift Ash Kieran , Dodwell David , Lord Simon , Petrou Stavros , Brady Sir Michael , Collins Gary S. , Hippisley-Cox Julia 
Published: October 2021

AbstractApart from high-risk scenarios such as the presence of highly penetrant genetic mutations, breast screening typically comprises mammography or tomosynthesis strategies defined by age. However, age-based screening ignores the range of breast cancer risks that individual women may possess and is antithetical to the ambitions of personalised early detection. Whilst screening mammography reduces breast cancer mortality, this is at the risk of potentially significant harms including overdiagnosis with overtreatment, and psychological morbidity associated with false positives. In risk-stratified screening, individualised risk assessment may inform screening intensity/interval, starting age, imaging modality used, or even decisions not to screen. However, clear evidence for its benefits and harms needs to be established. In this scoping review, the authors summarise the established and emerging evidence regarding several critical dependencies for successful risk-stratified breast screening: risk prediction model performance, epidemiological studies, retrospective clinical evaluations, health economic evaluations and qualitative research on feasibility and acceptability. Family history, breast density or reproductive factors are not on their own suitable for precisely estimating risk and risk prediction models increasingly incorporate combinations of demographic, clinical, genetic and imaging-related parameters. Clinical evaluations of risk-stratified screening are currently limited. Epidemiological evidence is sparse, and randomised trials only began in recent years.
Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice
Authors: Xie Xin , Tie Yi-Fan , Lai Song , Zhang Yun-Long , Li Hui-Hua , Liu Ying 
Published: October 2021

AbstractExcess myocardial triacylglycerol accumulation (i.e., cardiac steatosis) impairs heart function, suggesting that enzymes promoting triacylglycerol metabolism exert essential regulatory effects on heart function. Comparative gene identification 58 (CGI-58) is a key enzyme that promotes the hydrolysis of triglycerides by activating adipose triglyceride lipase and plays a protective role in maintaining heart function. In this study, the effects of CGI-58 on heart function and the underlying mechanism were investigated using cardiac-specific CGI58-knockout mice (CGI-58cko mice). Echocardiography and pathological staining were performed to detect changes in the structure and function of the heart. Proteomic profiling, immunofluorescent staining, western blotting, and real-time PCR were used to evaluate molecular changes. In CGI-58cko mice, we detected cardiac hypertrophic remodeling and heart failure associated with excessive cardiac lipid accumulation, ROS production, and decreased expression of regulators of fatty acid metabolism. These changes were markedly attenuated in CGI-58cko mice injected with rAAV9-CGI58. A quantitative proteomics analysis revealed significant increases in the expression of ER stress-related proteins and decreases in proteins related to fatty acid and amino acid metabolism in the hearts of CGI-58cko mice. Furthermore, the inhibition of ER stress by the inhibitor 4-PBA improved mitochondrial dysfunction, reduced oxidative stress, and reversed cardiac remodeling and dysfunction in cultured cardiomyocytes or in CGI-58cko mice. Our results suggested that CGI-58 is essential for the maintenance of heart function by reducing lipid accumulation and ER stress in cardiomyocytes, providing a new therapeutic target for cardiac steatosis and dysfunction.
Obesity in pregnant women: a 20-year analysis of the German experience
Authors: Strauss Alexander , Rochow Niels , Kunze Mirjam , Hesse Volker , Dudenhausen Joachim W. , Voigt Manfred 
Published: October 2021

AbstractBackground/objectiveTo investigate the longitudinal development of maternal body weight and analyze the influence of obesity on obstetrics during more than two decades in Germany.Subjects/methodsData collected from the Federal state of Schleswig-Holstein (German Perinatal Survey) were analyzed with regard to the dynamics of maternal anthropometric variables (body weight, BMI) between 1995–7 and 2004–17. In total 335,511 mothers substantiated the presented study-collective. The statistical analysis was performed using IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY.ResultsMaternal BMI advanced significantly over the study period. Among a rise in mean periconceptional body weight (67.6–72.0 kg), the segment of obese women increased disproportionately (in average 9.4–19.2%). Despite the observed trend to late giving birth (mean maternal age 1995: 29.3 vs. 30.7 years in 2017), it was not advanced maternal age but parity that influenced the continuous increase in maternal weight (mean maternal body weight 1995–7: primi- bi-, multiparae 67.4, 68.3 and 69.0 kg vs. 2004–17: primi- bi-, multiparae 70.0, 71.5 and 73.2 kg respectively).ConclusionObesity is a major problem on health issues in obstetrics. Advancing maternal BMI, increasing mother’s age and derived prenatal risks considerably complicate pregnancy and delivery. It has to be emphasized that its consequences do not end with delivery or childbed, but represent a livelong burden to the mother and their offspring. Hence, multimodal strategies to reduce/control periconceptional body weight are mandatory.
The geography of intergenerational social mobility in Britain
Authors: Longley Paul A. , van Dijk Justin , Lan Tian 
Published: October 2021

AbstractEmpirical analysis of social mobility is typically framed by outcomes recorded for only a single, recent generation, ignoring intergenerational preconditions and historical conferment of opportunity. We use the detailed geography of relative deprivation (hardship) to demonstrate that different family groups today experience different intergenerational outcomes and that there is a distinct Great Britain-wide geography to these inequalities. We trace the evolution of these inequalities back in time by coupling family group level data for the entire Victorian population with a present day population-wide consumer register. Further geographical linkage to neighbourhood deprivation data allows us to chart the different social mobility outcomes experienced by every one of the 13,378 long-established family groups. We identify clear and enduring regional divides in England and Scotland. In substantive terms, use of family names and new historical digital census resources are central to recognising that geography is pivotal to understanding intergenerational inequalities.
Increasing large wildfires over the western United States linked to diminishing sea ice in the Arctic
Authors: Zou Yufei , Rasch Philip J. , Wang Hailong , Xie Zuowei , Zhang Rudong 
Published: October 2021

AbstractThe compound nature of large wildfires in combination with complex physical and biophysical processes affecting variations in hydroclimate and fuel conditions makes it difficult to directly connect wildfire changes over fire-prone regions like the western United States (U.S.) with anthropogenic climate change. Here we show that increasing large wildfires during autumn over the western U.S. are fueled by more fire-favorable weather associated with declines in Arctic sea ice during preceding months on both interannual and interdecadal time scales. Our analysis (based on observations, climate model sensitivity experiments, and a multi-model ensemble of climate simulations) demonstrates and explains the Arctic-driven teleconnection through regional circulation changes with the poleward-shifted polar jet stream and enhanced fire-favorable surface weather conditions. The fire weather changes driven by declining Arctic sea ice during the past four decades are of similar magnitude to other leading modes of climate variability such as the El Niño-Southern Oscillation that also influence fire weather in the western U.S.
CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice
Authors: Halperin D. , Stavsky A. , Kadir R. , Drabkin M. , Wormser O. , Yogev Y. , Dolgin V. , Proskorovski-Ohayon R. , Perez Y. , Nudelman H. , Stoler O. , Rotblat B. , Lifschytz T. , Lotan A. , Meiri G. , Gitler D. , Birk O. S. 
Published: October 2021

AbstractAttention-deficit hyperactivity disorder (ADHD) is a common childhood-onset psychiatric disorder characterized by inattention, impulsivity and hyperactivity. ADHD exhibits substantial heritability, with rare monogenic variants contributing to its pathogenesis. Here we demonstrate familial ADHD caused by a missense mutation in CDH2, which encodes the adhesion protein N-cadherin, known to play a significant role in synaptogenesis; the mutation affects maturation of the protein. In line with the human phenotype, CRISPR/Cas9-mutated knock-in mice harboring the human mutation in the mouse ortholog recapitulated core behavioral features of hyperactivity. Symptoms were modified by methylphenidate, the most commonly prescribed therapeutic for ADHD. The mutated mice exhibited impaired presynaptic vesicle clustering, attenuated evoked transmitter release and decreased spontaneous release. Specific downstream molecular pathways were affected in both the ventral midbrain and prefrontal cortex, with reduced tyrosine hydroxylase expression and dopamine levels. We thus delineate roles for CDH2-related pathways in the pathophysiology of ADHD.