bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 and telehealth
Authors: Adelman Deborah S. , Fant Catherine , Summer Georgianne 
Published: April 2021

Abstract:
In this second article of a three-part series, we explore how stakeholders can be educated on the use of telehealth technology and telemedicine. We address the need for staff and patient support for the transition to telehealth and offer suggestions to NPs for appropriate presentation and interaction with interdisciplinary teams and patients regarding telehealth.
Risk Factors for Preeclampsia: Results from a Cohort of Over 5000 Pregnancies in Spain
Authors: Cuenca Diana , Rolle Valeria , de Paco Matallana Katy , Valiño Nuria , Revello Rocio , Adiego Begoña , Mendoza Manel , Santacruz Belen , Gil Maria del Mar 
Published: April 2021

Abstract

Objective:
To determine the incidence of preeclampsia (PE) and preterm PE in Spain and to identify the risk factors for developing the disease.

Methods:
This is a multicenter prospective cohort study performed at six maternity units across Spain. Women with singleton pregnancies attending their first-trimester routine visit at the hospital were offered participation. Maternal and pregnancy characteristics, including mean arterial pressure, as well as ultrasound findings were recorded. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for subsequent development of PE.

Results:
A total of 5868 pregnancies were recruited for this study, including 174 (3.0%) cases of PE, 47 (0.8%) cases of preterm PE and 127 (2.2%) cases of term PE. Median maternal age was 33.9 years (interquartile range: 30.1 to 36.9) and median gestational age at the routine visit was 12.7  weeks (interquartile range: 12.3 to 13.0). However, 293 (5.0%) of the women were on aspirin treatment during pregnancy, likely reducing the true incidence of the disease. As expected, increasing body mass index (P < 0.001), uterine artery pulsatility index (P = 0.011) and mean arterial pressure (P < 0.001), assisted conception (P = 0.013), previous personal (P < 0.001) or family history of PE (P = 0.024) and chronic hypertension (P = 0.001) were identified as independent risk factors for developing subsequent PE during pregnancy. Screening for PE by maternal factors alone leads to a detection rate of 36.8% (64/174) at 10.0% (587/5868) screen positive rate.

Conclusion:
In Spain, 3.0% of singleton pregnancies are complicated by PE and 0.8% require delivery before term due to its severity. Screening of PE by risk factors alone is only able to detect about 40% of total PE at 10% screen-positive rate.
Employment Status in Individuals with Upper-Limb Amputation: A Survey of Current Trends
Authors: Lee Christina , Engdahl Susannah , Riegger Anna , Davis Alicia , Kelly Brian M. , Gates Deanna H. 
Published: April 2021

ABSTRACT

Introduction
After upper-limb amputation, employment opportunities may be limited. Given the dramatic shift in the job market in the United States in the recent years, there is a need to examine the updated employment rates and the types of occupations to which individuals with amputation can return to. In this study, we assessed current employment status for people with upper-limb loss and determined whether these individuals needed to change jobs as a result of limb loss. Second, we examined whether demographic or impairment-specific factors were correlated with employment status or the need to switch jobs.

Materials and methods
Individuals with upper-limb amputation provided personal and employment information in an online survey. We explored the bivariate relationships between employment status and 11 personal factors (e.g., age at amputation, highest education level). Using the significant factors from this analysis, we built a logistic regression model for postamputation employment status. We also explored the relationship between these same 11 factors and the individuals' need to switch jobs after limb loss.

Results
A total of 199 and 160 respondents were deemed eligible for the employment status and job switch analyses, respectively. Of the working-aged respondents, 60.8% (121/199) were employed at the time of survey. Twenty-nine percent (47/160) reported needing to change jobs because of their amputation. Factors negatively associated with employment included having a bilateral amputation, lower education level, older age at amputation, higher pain frequency, and wearing a prosthesis less frequently. Higher education level was the only significant predictor of successful employment in the logistic regression model. There were no significant relationships between any factor and the need to change jobs after amputation.

Conclusions
The results suggest that individuals with upper-limb amputation have a lower employment rate than the national average. Future work should focus on understanding the reasons behind employment challenges in this population.
Hysteroscopic morcellation for removal of persistent placental remnants in the uterine cornu
Authors: Yu Fan , Li Zhimin , Wang Yi , Yue Zhen , Zhong Yuanyue , Zeng Liqin 
Published: April 2021

Abstract

Rationale:
Hysteroscopic morcellation is an alternative approach for the removal of placental remnants, given its advantages of safety, efficiency and good reproductive outcomes. This superiority can be even more obvious for removing persistent placental remnants in the lateral angle of the uterine cavity after repeated dilation and curettage (D&C) of an angular pregnancy, which is rarely reported.

Patient concerns:
Two patients who were both initially misdiagnosed as having missed intrauterine miscarriages underwent repeated suction-assisted D&C procedures and were found to have persistent placental remnants in the lateral angles of the uterine cavity.

Diagnoses:
Ultrasound and hysteroscopy evaluations showed that placental remnants in both cases were in the lateral uterine angles and protruding to the interstitial myometrium around the fallopian tube. We corrected the diagnosis to that of angular pregnancy according to a comprehensive consideration of the ultrasound, hysteroscopy and pathology results.

Interventions:
We performed MyoSure hysteroscopic morcellation for both patients and the placental remnants were removed completely without any complication.

Outcomes:
The patients were both scheduled for a second-look hysteroscopy 1 to 3 months after surgery, which revealed normal morphology of the uterine cavities and tubal ostia. The patients both achieved normal intrauterine pregnancies several months after surgery.

Lessons:
Hysteroscopic morcellation is a good alternative approach for the removal of placental remnants and should be considered in cases in which there might be a high risk of incomplete evacuation or a high risk of uterine perforation, especially in cases of angular pregnancy.
The changing patterns of comorbidities associated with human immunodeficiency virus infection, a longitudinal retrospective cohort study of Medicare patients
Authors: Williams Nick D. , Huser Vojtech , Rhame Frank , Mayer Craig S. , Fung Kin Wah 
Published: April 2021

Abstract
The objective of this paper is to determine the temporal trend of the association of 66 comorbidities with human immunodeficiency virus (HIV) infection status among Medicare beneficiaries from 2000 through 2016.
We harvested patient level encounter claims from a 17-year long 100% sample of Medicare records. We used the chronic conditions warehouse comorbidity flags to determine HIV infection status and presence of comorbidities. We prepared 1 data set per year for analysis. Our 17 study data sets are retrospective annualized patient level case histories where the comorbidity status reflects if the patient has ever met the comorbidity case definition from the start of the study to the analysis year.
We implemented one logistic binary regression model per study year to discover the maximum likelihood estimate (MLE) of a comorbidity belonging to our binary classes of HIV+ or HIV– study populations. We report MLE and odds ratios by comorbidity and year.
Of the 66 assessed comorbidities, 35 remained associated with HIV– across all model years, 19 remained associated with HIV+ across all model years. Three comorbidities changed association from HIV+ to HIV– and 9 comorbidities changed association from HIV– to HIV+.
The prevalence of comorbidities associated with HIV infection changed over time due to clinical, social, and epidemiological reasons. Comorbidity surveillance can provide important insights into the understanding and management of HIV infection and its consequences.
Ranolazine in the prevention and treatment of atrial fibrillation
Authors: Yuan Chengdai , Luo Wei , Ren Xiaocao , Ya Maxiao , Yan Wenlong , Hui Quanbin 
Published: April 2021

Abstract

Background:
Atrial fibrillation (AF) is the most common clinical arrhythmia and a major cause of morbidity and mortality in clinical practice. This study aims to determine the ranolazine for prevention and treatment of atrial fibrillation.

Method:
This study adheres to the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Protocols. Chinese electronic Database (CBM, Wanfang, and CNKI) and international electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) will be searched for all relevant published articles. We will apply no language or the year of publication restrictions. Study selection, data collection, and assessment of study bias will be conducted independently by a pair of independent reviewers. The Cochrane risk of bias (ROB) tool will be used for the risk of bias assessment. The quality of evidence will be evaluated by Grading of Recommendations Assessment Development and Evaluation (GRADE) system. The statistical analysis of this meta-analysis will be calculated by Review manager version 5.3.

Results:
The results of this study will be published in a peer-reviewed journal.

Conclusion:
This review will evaluate the value of ranolazine interventions for patients with AF, and provide meaningful conclusions or high-level evidence for clinical practice and further research.

Trial registration:
This study protocol was registered in open Science framework (OSF), (Registration DOI: 10.17605/OSF.IO/T6W9Q).
Glycogen storage disease type VI with a novel PYGL mutation
Authors: Zhan Qian , Lv Zili , Tang Qing , Huang Li , Chen Xiuqi , Yang Meixiong , Lan Liancheng , Shan Qingwen 
Published: April 2021

Abstract

Rationale:
Glycogen storage disease (GSD) type VI is a rare disease caused by the inherited deficiency of liver phosphorylase.

Patient concerns:
The proband, a 61-month-old Chinese boy, manifested intermittent hematochezia, growth retardation, hepatomegaly, damage of liver function, mild hypoglycemia, and hyperlactatemia. The other patient was a 107-month-old Chinese girl with growth retardation, hepatomegaly, mild hypoglycemia, and hyperlactatemia. In order to further confirm the diagnosis, we conducted a liver biopsy and detected blood samples for their gene using IDT exon chip capture and high-throughput sequencing.

Diagnoses:
According to the clinical symptoms, physical examination, laboratory examinations, liver biopsy, and the genetic test finding, the 2 patients were diagnosed GSD VI.

Interventions:
They were treated mainly with uncooked cornstarch.

Outcomes:
There were 2 mutations of PYGL gene in this pedigree. c.2467C>T (p. Q823X) and c.2178-2A>C occurred both in the proband and his second sister.

Lessons:
As a novel mutation, c.2178-2A>C enriches the mutation spectrum of PYGL gene. The different degrees of elevated lactate is an unusual phenotype in GSD VI patients. It is not clear if this is caused by the new mutation of c. 2178-2A > C. Long-term complications remains to be observed.
Effectiveness and safety of Liuhe Pill for treating gout
Authors: Yang Chunsheng , Aletengbieke Zulifeiya , Liu Li , Bakeer Banu 
Published: April 2021

Abstract

Background:
Liuhe Pill as a famous traditional Chinese medicine formula is usually used to treat gout, acute pancreatitis, and cellulitis in China. But at present, there is no systematic evaluation report on its therapeutic effectiveness and safety of Liuhe Pill for treating gout. This protocol aims to assess the efficacy and safety of Liuhe Pill for treating gout.

Methods:
We will search the Web of Knowledge, EMBASEWANFANG DATA, China National Knowledge Infrastructure (CNKI), PubMed, ClinicalTrials.gov and Cochrane Library from inception to October 31, 2021 to retrieve relevant studies. We will also search citations of relevant primary and review. Authors of abstract in the meeting will be further searched in PubMed for potential full articles. To minimize the risk of publication bias, we will conduct a comprehensive search that included strategies to find published and unpublished studies. Two authors independently judged study eligibility and extracted data. Heterogeneity will be examined by computing the Q statistic and I

2
statistic.

Results:
This study assessed the efficiency and safety of Liuhe Pill for treating gout.

Conclusions:
This study will provide reliable evidence-based evidence for the clinical application of Liuhe Pill for treating gout.
The efficacy of a multistrain probiotic on cognitive function and risk of falls in patients with cirrhosis
Authors: Wang Na , Yao Wei , Ma Ruiping , Ren Fangfang 
Published: April 2021

Abstract

Objective:
The effect of probiotics on cognitive function and the risk of falling in cirrhosis patients have not been previously evaluated. We perform this protocol for systematic review and meta-analysis to evaluate the effect of a multistrain probiotic on cognitive function and the risk of falls in patients with cirrhosis.

Methods:
An all-round retrieval will be performed in 5 electronic journal databases from their inception to March 2021, which comprise Medline, Pubmed, Embase, ScienceDirect, and the Cochrane Library by 2 independent reviewers. Data extraction was performed independently, and any conflict was resolved before final analysis. Only randomized clinical trials were included in this study. The main endpoints were cognitive function and risk of falls, and the secondary endpoints were fall incidence, health-related quality of life (HRQOL), systemic inflammatory response, gut barrier, bacterial translocation, and fecal microbiota. The risk of bias assessment of the included studies was performed by 2 authors independently using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions.

Results:
We hypothesized that the multistrain probiotic improved cognitive function, risk of falls, and inflammatory response in patients with cirrhosis and cognitive dysfunction.

Conclusion:
This study expects to provide credible and scientific clinical evidence for the efficacy and safety of a multistrain probiotic on cognitive function and the risk of falls in patients with cirrhosis.

OSF registration number:
10.17605/OSF.IO/JKMTP.
The effect of comprehensive oral care program on oral health and quality of life in patients undergoing radiotherapy for head and neck cancer
Authors: Lee Hye-Ju , Han Dong-Hun , Kim Jin-Ho , Wu Hong-Gyun 
Published: April 2021

Abstract

Objectives:
The purpose of this study is to investigate the effect of the comprehensive oral care program on oral health status and symptoms in head and neck cancer (HNC) patients undergoing radiotherapy.

Methods:
This was a quasi-experimental study using a non-equivalent control group in non-synchronized design. All participants including control and experimental group were asked for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire H&N35 (EORTC QLQ-H&N35) and given an oral health education 4 times at baseline, immediate postradiotherapy, 3 months after radiotherapy, and 6 months after radiotherapy. In each visit except for final, the experimental group was given fluoride varnish application and fluoride mouth rinsing solution for daily use. Oral health examination for dental caries, plaque score (PS), bleeding on probing (BOP), and salivary flow rate was performed in baseline and 6 months after radiotherapy. Statistical analyses were done by paired t-tests and mixed ANCOVA repeated-measures analysis.

Results:
From November 1, 2013 to October 31, 2015, a total 61 patients undergoing radiotherapy for HNC cancer were enrolled (30 in control and 31 in experimental groups). Decrease in salivary flow rate was comparable between 2 groups. Dental caries increased in control group (P = .006); PS and BOP were decreased in experimental group (P < .001 and .004, respectively). Experimental group showed lower swallowing, speech problems, and less sexuality scores in EORTC QLQ-H&N35 than control group.

Conclusion:
We found improvement in oral health and the quality of life in HNC patients with comprehensive oral care intervention by dental professionals. Communicating and cooperating between the healthcare and dental professionals is needed to raise the quality of health care services for HNC patients receiving radiotherapy.
Establishment of a clinical diagnostic model for gouty arthritis based on the serum biochemical profile
Authors: Lyu Shang , Ding Ruowen , Yang Shilin , Chen Wanyuan , Rao Yi , OuYang Hui , Liu Peng , Feng Yulin 
Published: April 2021

Abstract
The disease progression of gouty arthritis (GA) is relatively clear, with the 4 stages of hyperuricemia (HUA), acute gouty arthritis (AGA), gouty arthritis during the intermittent period (GIP), and chronic gouty arthritis (CGA). This paper attempts to construct a clinical diagnostic model based on blood routine test data, in order to avoid the need for bursa fluid examination and other tedious steps, and at the same time to predict the development direction of GA.
Serum samples from 579 subjects were collected within 3 years in this study and were divided into a training set (n = 379) and validation set (n = 200). After a series of multivariate statistical analyses, the serum biochemical profile was obtained, which could effectively distinguish different stages of GA. A clinical diagnosis model based on the biochemical index of the training set was established to maximize the probability of the stage as a diagnosis, and the serum biochemical data from 200 patients were used for validation.
The total area under the curve (AUC) of the clinical diagnostic model was 0.9534, and the AUCs of the 5 models were 0.9814 (Control), 0.9288 (HUA), 0.9752 (AGA), 0.9056 (GIP), and 0.9759 (CGA). The kappa coefficient of the clinical diagnostic model was 0.80.
This clinical diagnostic model could be applied clinically and in research to improve the accuracy of the identification of the different stages of GA. Meanwhile, the serum biochemical profile revealed by this study could be used to assist the clinical diagnosis and prediction of GA.
Osteomuscular symptoms on motorcycles in the city of Rio Branco, Acre, Brazil, West Amazon
Authors: Araújo Narjara Campos de , Souza Orivaldo Florêncio de , Morais Mauro José de Deus , Leitão Francisco Naildo Cardoso , Bezerra Italla Maria Pinheiro , Abreu Luiz Carlos de , Rodrigues Luciano Miller Reis 
Published: April 2021

Abstract
Musculoskeletal disorders gradually affect workers in different parts of the world, compromising their occupational health and quality of life. Professionals exposed to these symptoms include the motorcycle taxi driver, whose pain is due to the overuse of the musculoskeletal system and little time to recover it.
To identify the prevalence of musculoskeletal symptoms in motorcycle taxi drivers in the city of Rio Branco, Acre, Brazil, West Amazon.
Cross-sectional study, involving 296 motorcycle taxi drivers in the city of Rio Branco-Acre, Brazil, male, from December 2016 to February 2017. The Nordic Musculoskeletal Questionnaire was used to collect information related to symptoms (pain, discomfort, or numbness) in the last 7 days of work. For the exclusion criteria were, being female; not reside outside the city of Rio Branco, Acre; having less than 3 months of work activity; not be carrying out their work activities at the time of application of the protocol; be limited by clinical or physical issues at the time of application of the protocol. The data obtained in the questionnaire were entered into the Epidata program (Epidata Association, Odense, Denmark) and then transferred to the STATA 10 statistical program (Stata Corp., College Station), for categorization and statistical analysis.
The study population is over 36 years old; most reported having a partner and a higher education level. The average daily working hours of the participants were 12 hours, with the majority working over 12 hours daily. Most of the epidemiological variables factors were associated with musculoskeletal pain when the prevalence and prevalence ratio analyzes were performed. Higher prevalence of musculoskeletal symptoms in the lumbar region is with 17.9%. In the lower limbs, the most affected joint was the ankle (5.7%), followed by the hip (5.07%) and knee (5.07%), respectively. Insomnia was present in 55.35% and self-reported headache in 49.4% of participants.
The musculoskeletal disorders generated by the daily service of motorcycle taxi drivers are directly affecting the quality of life of these professionals.
The efficacy of high-power short-duration radiofrequency for atrial fibrillation ablation
Authors: Zhang Peng , Ma Ling , Wang Fei , Shi Liang 
Published: April 2021

Abstract

Background:
Studies comparing data between the high-power short-duration radiofrequency (HPSR) and low power longer duration therapy were limited and inconsistent. Therefore, we conduct a high-quality systematic review and meta-analysis to assess the efficacy and safety of HPSR on outcomes for patients with atrial fibrillation (AF).

Methods:
The online literature is searched using the following combination of medical subject heading terms: “high-power” OR “high power” AND “radiofrequency” AND “atrial fibrillation.” MEDLINE (PubMed), EMBASE (OVID), Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science (ISI database) will be searched without any language restrictions. All clinical trials to assess the efficacy and safety of HPSR in the treatment of atrial fibrillation will be considered eligible for analysis. The present study will be performed by Review Manager Software (RevMan Version 5.3, The Cochrane Collaboration, Copenhagen, Denmark). Ethical approval and patient consent are not required because this study is a literature-based study.

Results:
This study expects to provide credible and scientific evidence for the efficacy and safety of HPSR on outcomes for patients with AF.

Registration number:
10.17605/OSF.IO/WAEBN.