bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune-related Gene-based Prognostic Signature for the Risk Stratification Analysis of Breast Cancer
Authors: Su Dongqing , Lu Qianzi , Pan Yi , Yu Yao , Wang Shiyuan , Zuo Yongchun , Yang Lei 
Published: October 2021

Background:Breast cancer has plagued women for many years and caused many deaths around the world.Method:In this study, based on the weighted correlation network analysis, univariate Cox regression analysis, and least absolute shrinkage and selection operator, 12 immune-related genes were selected to construct the risk score for breast cancer patients. The multivariable Cox regression analysis, gene set enrichment analysis, and nomogram were also conducted in this study.Results:Good results were obtained in the survival analysis, enrichment analysis, multivariable Cox regression analysis and immune-related feature analysis. When the risk score model was applied in 22 breast cancer cohorts, the univariate Cox regression analysis demonstrated that the risk score model was significantly associated with overall survival in most of the breast cancer cohorts.Conclusion:Based on these results, we could conclude that the proposed risk score model may be a promising method and may improve the treatment stratification of breast cancer patients in the future work.
Use of Commercially Produced Medical Education Videos in a Cardiovascular Curriculum: Multiple Cohort Study
Authors: Tackett Sean , Green David , Dyal Michael , O'Keefe Erin , Thomas Tanya Emmanuelle , Nguyen Tiffany , Vo Duyen , Patel Mausam , Murdock Christopher J , Wolfe Erin M , Shehadeh Lina A 
Published: October 2021

Background
Short instructional videos can make learning more efficient through the application of multimedia principles, and video animations can illustrate the complex concepts and dynamic processes that are common in health sciences education. Commercially produced videos are commonly used by medical students but are rarely integrated into curricula.

Objective
Our goal was to examine student engagement with medical education videos incorporated into a preclinical Cardiovascular Systems course.

Methods
Students who took the first-year 8-week Cardiovascular Systems course in 2019 and 2020 were included in the study. Videos from Osmosis were recommended to be watched before live sessions throughout the course. Video use was monitored through dashboards, and course credit was given for watching videos. All students were emailed electronic surveys after the final exam asking about the course’s blended learning experience and use of videos. Osmosis usage data for number of video views, multiple choice questions, and flashcards were extracted from Osmosis dashboards.

Results
Overall, 232/359 (64.6%) students completed surveys, with rates by class of 81/154 (52.6%) for MD Class of 2022, 39/50 (78%) for MD/MPH Class of 2022, and 112/155 (72.3%) for MD Class of 2023. Osmosis dashboard data were available for all 359 students. All students received the full credit offered for Osmosis engagement, and learning analytics demonstrated regular usage of videos and other digital platform features. Survey responses indicated that most students found Osmosis videos to be helpful for learning (204/232, 87.9%; P=.001) and preferred Osmosis videos to the traditional lecture format (134/232, 57.8%; P<.001).

Conclusions
Commercial medical education videos may enhance curriculum with low faculty effort and improve students’ learning experiences. Findings from our experience at one medical school can guide the effective use of supplemental digital resources for learning, and related evaluation and research.
Delivering Cardiac Rehabilitation Exercise Virtually Using a Digital Health Platform (ECME-CR): Protocol for a Pilot Trial
Authors: Giggins Oonagh M , Doyle Julie , Smith Suzanne , Moran Orla , Gavin Shane , Sojan Nisanth , Boyle Gordon 
Published: October 2021

Background
Exercise-based cardiac rehabilitation is recognized as a core component of cardiovascular disease management and has been shown to reduce all-cause and cardiovascular mortality and reduce the risk of hospital readmission following a cardiac event. However, despite this, the uptake of and long-term adherence to cardiac rehabilitation exercise is poor. Delivering cardiac rehabilitation exercise virtually (ie, allowing patients to participate from their own homes) may be an alternative approach that could enhance uptake and increase adherence.

Objective
The aim of this study is to assess the feasibility of delivering a virtual cardiac rehabilitation exercise program supported by the Eastern Corridor Medical Engineering – Cardiac Rehabilitation (ECME-CR) platform.

Methods
A convenience sample (n=20) of participants eligible to participate in community-based cardiac rehabilitation exercise will be recruited. Participants will be randomized to one of two study groups. Both study groups will perform the same exercise program, consisting of twice-weekly sessions of 60 minutes each, over an 8-week intervention period. Participants in the intervention group will partake in virtually delivered cardiac rehabilitation exercise classes in their own home. The virtual exercise classes will be delivered to participants using a videoconferencing platform. Participants in the control group will attend the research center for their cardiac rehabilitation exercise classes. Intervention group participants will receive the ECME-CR digital health platform for monitoring during the class and during the intervention period. Outcomes will be assessed at baseline and following the 8-week intervention period. The primary outcome will be exercise capacity as assessed using the 6-minute walk test. Other outcome measures will include heart rate, blood pressure, weight, percentage body fat, muscle strength, and self-reported quality of life. Semistructured interviews will also be conducted with a subset of participants to explore their experiences of using the digital platform.

Results
Participant recruitment and data collection will begin in July 2021, and it is anticipated that the study results will be available for dissemination in spring 2022.

Conclusions
This pilot trial will inform the design of a randomized controlled trial that will assess the clinical effectiveness of the ECME-CR digital health platform.

International Registered Report Identifier (IRRID)
PRR1-10.2196/31855
Excess Mortality During the COVID-19 Pandemic in Jordan: Secondary Data Analysis
Authors: Khader Yousef , Al Nsour Mohannad 
Published: October 2021

Background
All-cause mortality and estimates of excess deaths are commonly used in different countries to estimate the burden of COVID-19 and assess its direct and indirect effects.

Objective
This study aimed to analyze the excess mortality during the COVID-19 pandemic in Jordan in April-December 2020.

Methods
Official data on deaths in Jordan for 2020 and previous years (2016-2019) were obtained from the Department of Civil Status. We contrasted mortality rates in 2020 with those in each year and the pooled period 2016-2020 using a standardized mortality ratio (SMR) measure. Expected deaths for 2020 were estimated by fitting the overdispersed Poisson generalized linear models to the monthly death counts for the period of 2016-2019.

Results
Overall, a 21% increase in standardized mortality (SMR 1.21, 95% CI 1.19-1.22) occurred in April-December 2020 compared with the April-December months in the pooled period 2016-2019. The SMR was more pronounced for men than for women (SMR 1.26, 95% CI 1.24-1.29 vs SMR 1.12, 95% CI 1.10-1.14), and it was statistically significant for both genders (P<.05). Using overdispersed Poisson generalized linear models, the number of expected deaths in April-December 2020 was 12,845 (7957 for women and 4888 for men). The total number of excess deaths during this period was estimated at 4583 (95% CI 4451-4716), with higher excess deaths in men (3112, 95% CI 3003-3221) than in women (1503, 95% CI 1427-1579). Almost 83.66% of excess deaths were attributed to COVID-19 in the Ministry of Health database. The vast majority of excess deaths occurred in people aged 60 years or older.

Conclusions
The reported COVID-19 death counts underestimated mortality attributable to COVID-19. Excess deaths could reflect the increased deaths secondary to the pandemic and its containment measures. The majority of excess deaths occurred among old age groups. It is, therefore, important to maintain essential services for the elderly during pandemics.
Por el bienestar de los demás
Authors: Ramírez Chicharro Manuel 
Published: October 2021

En el marco de los proyectos democratizadores en Cuba y México durante los años treinta y cuarenta, las feministas se convirtieron en importantes agentes del cambio. A veces, en el marco de los proyectos de modernización nacional propuestos desde los órganos de poder político. En otros momentos, planteando sus propios programas de intervención. Este artículo contribuye a complejizar las relaciones entre feminismo, educación y asistencialismo comparando los congresos y ruegos petitorios de las ligas feministas de carácter progresista que actuaron en Cuba y México durante los años treinta y cuarenta, concluyendo que sus diagnósticos y propuestas fueron similares a pesar de operar bajo marcos jurídicos distintos y procesos históricos conectados, aunque dispares.
Pengetahuan dan Motivasi Kepatuhan Protokol Kesehatan Covid-19 : Survei Online pada Mahasiswa Jawa Timur
Authors: Helmina Salma Nur , Linawati Hasna , Nisa Hoirun 
Published: October 2021

The government has made various efforts to prevent and control COVID-19, such as enforcing the law concerning the COVID-19 Health Protocols. However, violations of health protocols still frequently occur in various circles, including university students. Therefore, this study aims to determine the factors that influence university students’ compliance with the COVID-19 health protocols. This study used a cross-sectional study design with a quota sampling technique and was conducted in October 2020. The participants were 468 university students in East Java. The number of participants who complied with the COVID-19 health protocols was 61.3%, while those who did not comply were still quite high (38.7%). The factors that were significantly related to compliance with the COVID-19 health protocols were knowledge, motivation, and health problems, while lifestyle changes were not significantly related to compliance with the COVID-19 health protocols. Participants with high level of knowledge (AOR 5.54 95% CI: 2.68-11.49), good motivation (AOR 2.15 95% CI: 1.43-3.22), and health problems (AOR 1.19 95% CI: 0.52-2.73) are more likely to comply with the COVID-19 health protocols. Thus,concerted efforts are needed to increase knowledge and motivation so that compliance with the COVID-19 health protocol significantly increases. Keywords: Knowledge, Motivation, Health Problems, Compliance
Abstrak
Pemerintah telah melakukan berbagai upaya pencegahan dan penanggulangan COVID-19 seperti penegakan hukum dengan Protokol Kesehatan COVID-19. Namun, pelanggaran terhadap protokol kesehatan masih sering terjadi di berbagai kalangan termasuk mahasiswa. Oleh karena itu, penelitian ini bertujuan untuk mengetahui faktor yang mempengaruhi kepatuhan protokol kesehatan COVID-19 pada mahasiswa. Penelitian ini menggunakan desain studi potong-lintang dengan teknik quota sampling dan dilakukan pada bulan Oktober 2020. Partisipan pada penelitian ini sebanyak 468 mahasiswa di Jawa Timur. Partisipan mahasiswa yang patuh terhadap protokol kesehatan COVID-19 sebesar 61,3%, sedangkan yang tidak patuh masih cukup tinggi (38,7%). Faktor yang berhubungan signifikan dengan kepatuhan protokol kesehatan COVID-19 adalah pengetahuan, motivasi, dan masalah kesehatan sedangkan perubahan gaya hidup tidak berhubungan signifikan dengan kepatuhan protokol kesehatan COVID-19. Partisipan dengan pengetahuan yang tinggi (AOR 5,54 95% CI: 2,68-11,49), motivasi baik (AOR 2,15 95% CI:1,43-3,22), dan memiliki masalah kesehatan (AOR 1,19 95% CI: 0,52-2,73) cenderung lebih patuh untuk terhadap protokol kesehatan COVID-19. Dengan demikian, diperlukan upaya yang terencana untuk meningkatkan pengetahuan dan motivasi supaya kepatuhan terhadap protokol kesehatan COVID-19 meningkat secara signifikan.
Kata kunci: Pengetahuan, Motivasi, Masalah Kesehatan, Kepatuhan
Competences for education for sustainability: analysis of educational policy documents in Portugal
Authors: Sá Patrícia , Andrade Ana Isabel , Machado Jane , Sá Cristina 
Published: October 2021

The present study is part of the TEDS - Teacher Education for Sustainability project. This is an Erasmus+ project and involves five European countries: Portugal, France, Lithuania, Finland and Malta. The main aim of the TEDS project is to provide European teacher educators and teachers with the knowledge and tools necessary to implement an education that promotes sustainability in their practices. Within this project, one of the objectives was to understand how key competences in education for sustainability are present in the educational documents of each of the participating countries. This article refers to the analysis carried out on Portuguese educational documents. It is a qualitative study framed on the interpretive paradigm. It is an exploratory, descriptive-interpretive study aimed at identifying and describing the main characteristics related to the key competences in education for sustainability present in the official Portuguese documents that guide teaching and learning. After the analysis, validation and discussion of the results of the content analysis carried out on the corpus, these seem to indicate that the educational documents analyzed are compatible with the key competences considered in the guiding reference framework. All documents present different aspects of the various competences, highlighting their importance in the foundation of an educational practice that promotes sustainability.
QUANDO O DIÁLOGO FREIREANO É BASE PARA A INCLUSÃO ESCOLAR
Authors: Tinôco Saimonton 
Published: October 2021

Neste artigo objetivamos identificar as estratégias de organização do trabalho pedagógico inclusivo, no âmbito da sala de aula e da escola, desencadeadas a partir de um diálogo propositivo. Sendo assim, relatamos parte de uma pesquisa realizada numa escola privada de médio porte de uma capital do Nordeste, por um período de um semestre, quando foram realizadas observações e conversas com diferentes profissionais que a compõem. O diálogo freiriano se fez presente em todos os momentos do percurso, constituindo-se enquanto alternativa de escuta, acolhimento e problematização do fazer e do saber docente. Desse modo, identificamos algumas estratégias vivenciadas durante o diálogo estabelecido com o contexto escolar, quais sejam: o acompanhamento ao/à professor(a) regente, a participação de professor(a) auxiliar, o trabalho ético com todos os/as estudantes, a participação da família e a colaboração de profissionais de fora da escola. Por fim, entendemos que o diálogo freireano pode e deve ser utilizado como um recurso para uma crítica à realidade educacional, a construção coletiva, a tomada de decisão e o desenvolvimento pessoal e profissional. A presença do diálogo no ambiente escolar promove uma aproximação entre as pessoas que compõem a comunidade educativa, como também entre os seus discursos, estabelecendo redes de colaboração. Por esse motivo, é preciso compartilhar, com todos(as) os/as envolvidos(as), os interesses, os dilemas e as estratégias do processo inclusivo, sejam eles pais, profissionais extra escola e estudantes.
Life Endangerment – A Paramount Condition in Forensic and Judicial Practice
Authors: Radu Carmen Corina , Hogea Timur , Doroftei Dana , Carașca Cosmin 
Published: October 2021

Abstract
Life-threatening injuries represent those types of lesions that certainly lead to the victim’s death if no qualified medical care is applied in due time. We hold important the aspect of imminent danger, and that the lesion, in its natural way of evolution, will determine the person’s death, his life being saved only by a qualified medical intervention. The juridical correspondent is represented in article 194: bodily harm - The new criminal code and the new criminal procedure code. The authors review and comment on the main particular aspects of life-threatening traumas, based on topography, anatomical aspects and forensic interpretation, in order to offer arguments to be incorporated from a medico-legal point of view, reported to the criteria of life-threatening conditions. We shall illustrate the subject by 6 case reports.
Genotoxicity of chromium (III) and cobalt (II) and interactions between them
Authors: Czarnek Katarzyna , Siwicki Andrzej K. 
Published: October 2021

Abstract

Introduction. Chromium and cobalt are essential trace elements that are required only in a small amount, otherwise their excess can cause toxic effects.

Aim. The aim of this study was to determine the effects of chromium (III) and cobalt (II) and their combinations on genotoxicity in human fibroblasts cells (BJ).

Material and methods. In this work, comet and micronucleus assays were used. The BJ cells were exposed to chromium chloride and cobalt chloride at concentration ranges from 100 to 1400 µM. Mixtures of these elements were prepared so as to examine interactions between them.

Results. The present study shows the genotoxic effects of chromium (III) and cobalt (II) and their mixtures on BJ cells. In the comet assay, no comets were observed at the lowest concentrations; in the higher, a significant increase in their percentage was observed. In the other assay (formation of micronuclei), a statistically significant increase in the number of cells with micronuclei was observed in the BJ cells spiked with cobalt chloride and chromium chloride. In the case of simultaneous incubation of chromium chloride at 200 µM and cobalt chloride at 1000 µM in the BJ line, antagonism was observed. However, the interaction of chromium chloride at the 1000 µM and cobalt chloride at 200 µM leads to synergism between the studied elements.

Conclusions. Cobalt (II) and chromium (III) show genotoxic properties, they induce breaks in double and single-stranded DNA and they cause formation of AP-sites that do not have purine or pyrimidine bases.
Alone in the Country of the Catholics: Labrador Inuit in Prague (1880)
Authors: Křížová Markéta 
Published: October 2021

AbstractThe ethnographic shows of the end of the 19thcentury responded to an increased hunger for the exotic, especially among the bourgeois classes in Europe and North America, and to the establishment of both physical and cultural anthropology as scientific disciplines with a need for study material. At the same time they served as a manifestation of European superiority in the time of the last phase of colonialist thrust to other continents. “Scientific colonialism” reached also to regions without actual colonial or imperial ambitions, as the story of Labrador Inuit who visited Prague during their tour of Europe in November 1880 will prove. The reactions of local intellectuals and the general public to the performances of the “savages” will be examined in the context of the Czech and German nationalist competition and the atmosphere of colonial complicity. Thanks to the testimony of a member of the group, Abraham Ulrikab, supplemented by newspaper articles and other sources, it is possible to explore the miscommunication arising from the fact that the Inuit were members of the Moravian Church, professing allegiance to old Protestant tradition in the Czech Lands and cultivating a fragmented knowledge of Czech history and culture.
Examination of the Role of Corporate Branding in Achieving Business Excellence Requirements in Agencies of Algerian Companies
Authors: Derroum Ahmed , Haouati Ouarda 
Published: October 2021

Abstract
This study seeks to define the role of corporate brands in achieving business excellence by conducting a field study on the agencies of Algerian mobile operators “Mobilis” and “Djezzy” in the state of Djelfa where the questionnaire has been used for the collection of opinions sample (45 employees) and then processed with the statistical program (SPSS). The results have shown that there is high awareness of corporate brands and business excellence. We have also found that the two dimensions of corporate brand (strategic vision, stakeholder image) affect the business excellence, whereas the organizational culture does not affect it. The results have also demonstrated that corporate brands as a group explain 47 % of the variation in business excellence, while the difference test have demonstrated that the awareness of the sample about “corporate brands” is not different according to the company but the awareness of the business excellence is in favor of the company “Mobilis” at the expense of the mobile operator “Djezzy”.
Syntaxonomy and ecological differentiation of the pioneer vegetation of Ukraine Classes: Isoëto-Nanojuncetea, Bidentetea
Authors: Dubyna Dmytro V. , Dziuba Tetiana P. , Iemelianova Svitlana M. , Felbaba-Klushyna Lyubov M. 
Published: October 2021

Abstract
The studies of the pioneer vegetation of freshwater shorelines of water bodies are of particular interest owing to the specific ecology of these habitats and the short cycle for their development in which periods of flooding and subsequent drainage alternate. Using the methods of phytosociological classification and cluster analysis based on the interpretation of 414 phytosociological relevés, the syntaxonomic structure of the pioneer vegetation of freshwater shorelines of the water bodies of Ukraine has been established that are represented by the phytosociological classes Isoëto-Nanojuncetea and Bidentetea. The class Isoëto-Nanojuncetea includes 8 associations that belong to 2 alliances and 1 order and the class Bidentetea includes 10 associations belonging to 2 alliances and 1 order. Phytocoenoses of both classes are more typical for the Polissia region and the forest-steppe zone of Ukraine, where there are favourable habitats with a flat relief, low degree of dissection and a high level of soil humidity. Using a DCA ordination analysis of associations their position in ecological space was determined. It was established that the main factors of ecological differentiation for Isoëto-Nanojuncetea habitats are soil humidity, soil aeration, nitrogen content, as well as temperature regime. Differentiation in the hyperspace of abiotic factors of the class Bidentetea occurs mainly along the gradients of soil humidity, salt regime and acidity. The ecological distribution of syntaxa of this class is also significantly influenced by the concentration of mineral nitrogen compounds in the soil.