bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Narrative Shape of Orthopraxy: Storytelling,Dharma, and the Path to Liberation in Advaita Vedānta
Authors: Madaio James 
Published: November 2021

AbstractThis article analyses how Vidyāraṇya, a fourteenth-century Advaita Vedāntin, reads and re-tells life stories of exemplary sages to determine and establish duty, or dharma, on the Advaita Vedāntic path to liberation. Drawing on his Jīvanmuktiviveka, I show how Vidyāraṇya’s extrapolative, exegetical approach to life stories is shaped by hermeneutical concerns of the Dharmaśāstra tradition, which entails a narrative theology sensitive to the details of canonical life stories. In particular, the article closely examines Vidyāraṇya’s interpretation of episodes in the life of Yājñavalkya from the Bṛhadāraṇyaka Upaniṣad; Rāma, Śuka, Janaka, and Bhagīratha from the ‘Laghuyogavāsiṣṭha’; as well as the story of Nidāgha from the Viṣṇupurāṇa. I demonstrate how Vidyāraṇya’s reading of these narratives, including his diagnostic assessment of the soteriological status of the protagonists, engenders and authorises orthopraxy on the path to liberation. While setting out these issues, I pay particular attention to the way in which narrative accounts serve not only as theologically rich sources from which praxeological and theological positions are determined but also as examples in Vidyāraṇya’s argumentation.
3D mesoscopic architecture of a heterogeneous cellular network in the cementum–periodontal ligament–alveolar bone complex
Authors: Hirashima Shingo , Ohta Keisuke , Togo Akinobu , Nakamura Kei-ichiro 
Published: November 2021

AbstractCell-to-cell communication orchestrates various cell and tissue functions. This communication enables cells to form cellular networks with each other through direct contact via intercellular junctions. Because these cellular networks are closely related to tissue and organ functions, elucidating the morphological characteristics of cellular networks could lead to the development of novel therapeutic approaches. The tooth, periodontal ligament (PDL) and alveolar bone form a complex via collagen fibres. Teeth depend on the co-ordinated activity of this complex to maintain their function, with cellular networks in each of its three components. Imaging methods for three-dimensional (3D) mesoscopic architectural analysis include focused ion beam/scanning electron microscopy (FIB/SEM), which is characterized by its ability to select observation points and acquire data from complex tissue after extensive block-face imaging, without the need to prepare numerous ultrathin sections. Previously, we employed FIB/SEM to analyse the 3D mesoscopic architecture of hard tissue including the PDL, which exists between the bone and tooth root. The imaging results showed that the cementum, PDL and alveolar bone networks are in contact and form a heterogeneous cellular network. This cellular network may orchestrate mechanical loading–induced remodelling of the cementum–PDL–alveolar bone complex as the remodelling of each complex component is coordinated, as exemplified by tooth movement due to orthodontic treatment and tooth dislocation due to occlusal loss. In this review, we summarize and discuss the 3D mesoscopic architecture of cellular networks in the cementum, PDL and alveolar bone as observed in our recent mesoscopic and morphological studies.
Parent and Well-Sibling Communication in Families With a Child Who Has a Life-Limiting Condition: Quantitative Survey Data
Authors: Jaaniste Tiina , Chin Wei Ling (Audrey) , Tan Sarah Caellainn , Cuganesan Anjali , Coombs Sandra , Heaton Maria , Cowan Sue , Potter Denise , Aouad Phillip , Smith Philippa Louise , Trethewie Susan 
Published: November 2021

Abstract

Objective
Living with a child with a life-limiting condition (LLC), for which there is no hope of cure and premature death is expected, places much stress on a family unit. Familial communication has the potential to serve as a buffer when children are faced with stressful situations. The overall aim of the study was to learn more about illness-related communication between parents and well-siblings, giving particular consideration to the amount of illness-related communication, and sibling satisfaction with familial communication.

Methods
Participants included 48 well-siblings (aged 6–21 years) of children with LLCs and their parents. Parents and well-siblings independently completed validated measures of familial communication and sibling functioning. Parents also provided demographic information and completed a questionnaire assessing amount of illness-related information provided to well-siblings.

Results
Parents reported that 47.8% of well-siblings never or rarely initiated conversations about their sibling's illness. Moreover, 52.2% of well-siblings never or rarely spoke about death. Amount of illness-related communication between parents and well-siblings was most strongly predicted by parental resilience and well-sibling age. Parents engaged in significantly more illness-related communication with girls than boys (t(44)=−2.28, p = .028). Well-siblings (p &lt; .01) and parents (p &lt; .05) rated satisfaction with familial communication significantly higher than published norms. The only significant predictor of well-sibling satisfaction with familial communication was greater familial cohesion. Family communication variables were not significantly correlated with measures of sibling functioning (all p’s&gt;.05).

Conclusions
This study provides new information regarding parent and well-sibling communication in families who have a child with a LLC.
Concurrent granulomatous mastitis and invasive ductal cancer in contralateral breasts—a case report and review
Authors: Evans Jonathan , Sisk Louis , Chi Kee , Brown Shaun , To Henry 
Published: November 2021

Abstract
Idiopathic granulomatous mastitis (GM) is an uncommon chronic benign disease of the breast that is challenging to clinically distinguish from malignancy. However, it is unusual to diagnose GM concurrently with carcinoma in the same breast and rarer still to encounter GM and malignancy in contralateral breasts. We describe the case of a 39-year-old female who presented with right multifocal breast cancer and left granulomatous mastitis, discuss complexities in her management plan and review the literature on this unusual concurrent condition.
Delayed massive hemothorax after blunt thoracic trauma requiring thoracotomy by VATS: a case report
Authors: Park Chan Hee , Kim Kyeong Eui , Chae Min Cheol , Lee Jeong Woo 
Published: November 2021

Abstract
Delayed hemothorax after thoracic trauma is a rare type of thoracic injury that may require angioembolization and surgical treatment. We report a case of a 59-year-old man with a delayed massive hemothorax from a fall-induced blunt thoracic trauma, causing multiple right lower rib fractures. The patient fell from a chair while standing on and working from it. He was diagnosed with right 7th–11th rib fractures, scanty hemothorax and liver contusion. The patient was hospitalized and received conservative treatment, and a delayed massive hemothorax was present on the fourth day after the injury. Chest tube drainage and video-assisted thoracoscopic surgery were performed, and the patient was discharged 16 days after the surgery without bleeding or other complications. Delayed hemothorax should be considered when thoracic trauma patients complain of chest discomfort, dyspnea, cold sweating or fatigue. Early recognition, appropriate diagnosis and rapid intervention can improve prognosis and lead to successful patient treatment.
Pulmonary and aortic endarteritis revealing a patent ductus arteriosus in an adult
Authors: Bouhdadi H , Rhissassi J , Wazaren H , Idrissa M , Benlafqih C , Sayah R , Laaroussi M 
Published: November 2021

Abstract
The ductus arteriosus, an essential fetal structure, normally closes spontaneously soon after birth. Its persistence into late adulthood is considered to be rare; infective endarteritis (IE) complicating a patent ductus arteriosus (PDA) is an even rarer event. The clinical picture of an infected PDA could be subtle, and the diagnosis is frequently delayed. We present the case of a young woman who presented with prolonged fever for whom we made the diagnosis of a PDA complicated by IE, with vegetations in both pulmonary and aortic walls with mycotic aneurysms of the descending aorta. She underwent surgery and the post-operative course was uneventful. To our knowledge, this is the first reported case of a PDA complicated with both pulmonary and aortic endarteritis.
ABA-INSENSITIVE 3 with or without FUSCA3 highly up-regulates lipid droplet proteins and activates oil accumulation
Authors: Yang Zheng , Liu Xiangling , Wang Kai , Li Zhuowei , Jia Qingli , Zhao Cuizhu , Zhang Meng 
Published: November 2021

AbstractABA-INSENSITIVE 3 (ABI3) has long been known for activation of storage protein accumulation. A role of ABI3 on oil accumulation was previously suggested based on a decrease of oil content in seeds of abi3 mutant. However, this conclusion could not exclude possibilities of indirect or pleiotropic effects, such as through mutual regulatory interactions with FUSCA3 (FUS3), an activator of oil accumulation. To identify that ABI3 functions independent of the effects of related seed transcription factors, we expressed ABI3 under the control of an inducible promoter in tobacco BY2 cells and Arabidopsis rosette leaves. Inducible expression of ABI3 activated oil accumulation in these non-seed cells, demonstrating a general role of ABI3 in regulation of oil biosynthesis. Further expressing ABI3 in rosette leaves of fus3 knockout mutant still caused up to 3-fold greater triacylglycerol accumulation, indicating ABI3 can activate lipid accumulation independently of FUS3. Transcriptome analysis revealed that LIPID DROPLET PROTEIN (LDP) genes, including OLEOSINs and CALEOSINs, were up-regulated up to 1000-fold by ABI3 in the absence of FUS3, while the expression of WRINKLED1 was doubled. Taken together, our results provide genetic evidence that ABI3 activates oil accumulation with or without FUS3, most likely through up-regulating LDPs and WRINKLED1.
High-energy neutrinos from X-rays flares of blazars frequently observed by the Swift X-ray Telescope
Authors: Stathopoulos S I , Petropoulou M , Giommi P , Vasilopoulos G , Padovani P , Mastichiadis A 
Published: November 2021

ABSTRACT
Blazar flares have been suggested as ideal candidates for enhanced neutrino production. While the neutrino signal of γ-ray flares has been widely discussed, the neutrino yield of X-ray flares has received less attention. Here, we compute the predicted neutrino signal from X-ray flares detected in 66 blazars observed more than 50 times with the X-ray Telescope (XRT) on board the Neil Gehrels Swift  Observatory. We consider a scenario where X-ray flares are powered by synchrotron radiation of relativistic protons, and neutrinos are produced through photomeson interactions between protons with their own synchrotron X-ray photons. Using the 1 keV X-ray light curves for flare identification, the 0.5–10 keV fluence of each flare as a proxy for the all-flavour neutrino fluence, and the IceCube point-source effective area for different detector configurations, we calculate the number of muon and antimuon neutrinos above 100 TeV expected for IceCube from each flaring source. The bulk of the neutrino events from the sample originates from flares with durations ∼1–10 d. Accounting for the X-ray flare duty cycle of the sources in the sample, which ranges between ∼2 and 24 per cent, we compute an average yearly neutrino rate for each source. The median of the distribution (in logarithm) is ∼0.03 yr−1, with Mkn 421 having the highest predicted rate 1.2 ± 0.3 yr−1, followed by 3C 273 (0.33 ± 0.03 yr−1) and PG 1553+113 (0.25 ± 0.02 yr−1). Next-generation neutrino detectors together with regular X-ray monitoring of blazars could constrain the duty cycle of hadronic X-ray flares.
Constraints on star formation in NGC 2264
Authors: Parker Richard J , Schoettler Christina 
Published: November 2021

ABSTRACT
We quantify the spatial distribution of stars for two subclusters centred around the massive/intermediate-mass stars S Mon and IRS 1/2 in the NGC 2264 star-forming region. We find that both subclusters have neither a substructured nor a centrally concentrated distribution according to the $\mathcal {Q}$-parameter. Neither subcluster displays mass segregation according to the ΛMSR ratio, but the most massive stars in IRS 1/2 have higher relative surface densities according to the ΣLDR ratio. We then compare these quantities to the results of N-body simulations to constrain the initial conditions of NGC 2264, which are consistent with having been dense ($\tilde{\rho } \sim 10^4$ M⊙ pc−3), highly substructured and subvirial. These initial conditions were also derived from a separate analysis of the runaway and walkaway stars in the region, and indicate that star-forming regions within 1 kpc of the Sun likely have a broad range of initial stellar densities. In the case of NGC 2264, its initial stellar density could have been high enough to cause the destruction or truncation of protoplanetary discs and fledgling planetary systems due to dynamical encounters between stars in the early stages of its evolution.
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children’s Oncology Group study
Authors: Bartels Ute , Onar-Thomas Arzu , Patel Sunita K , Shaw Dennis , Fangusaro Jason , Dhall Girish , Souweidane Mark , Bhatia Aashim , Embry Leanne , Trask Christine L , Murphy Erin S , MacDonald Shannon , Wu Shengjie , Boyett James M , Leary Sarah , Fouladi Maryam , Gajjar Amar , Khatua Soumen 
Published: November 2021

AbstractBackgroundThe study aimed to evaluate whether simplified chemotherapy followed by dose-reduced irradiation was effective for treating patients (ages 3–21 years) with localized germinoma. The primary endpoint was 3-year progression-free survival (PFS) rate.MethodsPatients with a complete response to chemotherapy with carboplatin and etoposide received 18 Gy WVI + 12 Gy boost to the tumor bed. Patients with partial response proceeded to 24 Gy WVI + 12 Gy. Longitudinal cognitive functioning was evaluated prospectively on ALTE07C1 and was a primary study aim.ResultsOne hundred and fifty-one patients were enrolled; 137 were eligible. Among 90 evaluable patients, 74 were treated with 18 Gy and 16 with 24 Gy WVI. The study failed to demonstrate noninferiority of the 18 Gy WVI regimen compared to the design threshold of 95% 3-year PFS rate, where, per design, patients who could not be assessed for progression at 3 years were counted as failures. The Kaplan-Meier (KM)-based 3-year PFS estimates were 94.5 ± 2.7% and 93.75 ± 6.1% for the 18 Gy and 24 Gy WVI cohorts, respectively. Collectively, estimated mean IQ and attention/concentration were within normal range. A lower mean attention score was observed at 9 months for patients treated with 24 Gy. Acute effects in processing speed were observed in the 18 Gy cohort at 9 months which improved at 30-month assessment.ConclusionsWhile a failure according to the prospective statistical noninferiority design, this study demonstrated high rates of chemotherapy responses, favorable KM-based PFS and OS estimates in the context of reduced irradiation doses and holds promise for lower long-term morbidities for patients with germinoma.
An analog of Friedel oscillations in nanoconfined water
Authors: Xue Minmin , Hu Zhili , Qiu Hu , Shen Chun , Guo Wanlin , Zhang Zhuhua 
Published: November 2021

Abstract
Water confined in nanometer-scale crevices and cavities underpins a wide range of fundamental processes, such as capillary flow, ion transport and protein folding. However, how water responds within these confined spaces, with prevalent inhomogeneity built in or caused by impurities, is not well understood. Here, we show theoretically that water confined in one-dimensional nanochannels with localized perturbation exhibits pronounced density oscillations. The oscillations occur vividly like the Friedel oscillations in electron density resulting from defects in metals. A model analysis reveals that the density oscillations result from the perturbation-induced molecular scattering that is augmented by the confinement-enhanced correlation of water dipoles. This renders the oscillations a general behavior independent of the channel geometries and specific forms of the perturbation. Under confinements comparable to biological ion channels, such oscillations can strikingly extend over 10 nm, resulting in non-trivial effects at large distances that, for example, repel all ions from the channels with their long-range force. These results deepen the understanding of biological functions and inspire new applications in a variety of domains, such as ionic sensing and seawater desalination.
Resolving Frege’s Other Puzzle
Authors: Snyder Eric , Samuels Richard , Shapiro Stewart 
Published: November 2021

AbstractNumber words seemingly function both as adjectives attributing cardinality properties to collections, as in Frege’s ‘Jupiter has four moons’, and as names referring to numbers, as in Frege’s ‘The number of Jupiter’s moons is four’. This leads to what Thomas Hofweber calls Frege’s Other Puzzle: How can number words function as modifiers and as singular terms if neither adjectives nor names can serve multiple semantic functions? Whereas most philosophers deny that one of these uses is genuine, we instead argue that number words, like many related expressions, are polymorphic, having multiple uses whose meanings are systematically related via type shifting.
Fully automated opportunistic screening of vertebral fractures and osteoporosis on more than 150 000 routine computed tomography scans
Authors: Roux Christian , Rozes Antoine , Reizine Daniel , Hajage David , Daniel Christel , Maire Aurélien , Bréant Stéphane , Taright Namik , Gordon Ronen , Fechtenbaum Jacques  , Kolta Sami , Feydy Antoine , Briot Karine , Tubach Florence 
Published: November 2021

Abstract

Objective
Osteoporosis is underdiagnosed and undertreated, although severe complications of osteoporotic fractures, including vertebral fractures, are well known. This study sought to assess the feasibility and results of an opportunistic screening of vertebral fractures and osteoporosis in a large database of lumbar or abdominal CT scans.

Material and methods
Data were analysed from CT scans obtained in 35 hospitals from patients aged 60 years or older and stored in a Picture Archiving and Communication System in Assistance-Publique-Hôpitaux de Paris, from 2007 to 2013. Dedicated software was used to analyse the presence or absence of at least 1 vertebral fracture (VF), and the radiodensity of the lumbar vertebrae was measured Hounsfield Units (HUs). A simulated T-score was calculated.

Results
Data were analysed from 152 268 patients [mean age (S.D.) = 73.2 (9.07) years]. Success rates for VF assessment and HUs measurements were 82 and 87%, respectively. The prevalence of VFs was 24.5% and increased with age. Areas under the receiver operating characteristic curves for the detection of VFs were 0.61 and 0.62 for the mean HUs of the lumbar vertebrae and the L1 HUs, respectively. In patients without VFs, HUs decreased with age, similarly in males and females. The prevalence of osteoporosis (sT-score ≤ –2.5) was 23.8% and 36.5% in patients without and with VFs, respectively.

Conclusion
It is feasible on a large scale to screen for VFs and osteoporosis during opportunistic screening in patients 60 years or older having lumbar or abdominal CT.
The Long-Term Consequences of Imprisoning Our Youth: The Lasting Impact of Time Spent in Adult Jails and Prisons
Authors: Kurlychek Megan C , Kijowski Matthew C , Gagnon Alysha M 
Published: November 2021

AbstractWe explore the possible deleterious lifelong impacts for youth who serve stints of incarceration in adult jails or prisons. Our study uses a sample of all youth ages 16 and 17 arrested in New York State in 1987 and follows their criminal careers for 24 years. New York was selected as the state processed, not just some, but all youth of this age as adults, allowing us to overcome issues of selection bias and to use natural variation to create a propensity score matched sample to compare similar youth who either were, or who were not, subject to this punishment. Findings reveal that youth who spent time in an adult jail or prison recidivate more often, more quickly, and commit more total offenses. We also find that being offered youthful offender status, a status that removes the public stigma of a criminal record, reduces recidivism, regardless of the incarceration experience. Our study is situated in theories of deterrence, social learning, and labeling, and we apply our findings to greater societal implications of subjecting youth to punishments traditionally reserved for mature adults.
Exploring the Temporal Dynamics of County-Level Vulnerability Factors on COVID-19 Outcomes
Authors: Zhang Jing , Choi Daesung , Patel Shivani A , Ho Joyce C. 
Published: November 2021

AbstractAs the outbreak of COVID-19 has become a severe worldwide pandemic, every country fights against the spread of this deadly disease with incredible efforts. There are numerous researches along with every conceivable dimension for COVID-19. Among these researches, different demographic and contextual factors of populations and communities also play an essential role in providing more information for decision-makers. This paper mainly utilizes existing data on county contextual factors at the United States county-level to develop a model that can capture the dynamic trajectory of COVID-19 (i.e., cases) and its impacts across the United States. Moreover, our methods applied to contextual data achieves better results compared with existing measures of vulnerability.
A Comprehensive HPV-STI NGS Assay for Detection of 29 HPV Types and 14 non-HPV Sexually Transmitted Infections
Authors: Ma Zhihai , Gharizadeh Baback , Cai Xingsheng , Li Mengzhen , Fellner María Dolores , Basiletti Jorge Alejandro , Correa Rita Mariel , Colucci María Celeste , Baldoni Gabriela , Vacchino Martín , Galarza Patricia , Picconi María Alejandra , Wang Chunlin 
Published: November 2021

ABSTRACTSexually transmitted infections (STIs) are prevalent throughout the world and impose a significant burden on individual health and public health systems. Missed diagnosis and late treatment of STIs can lead to serious complications such as infertility and cervical cancer. Although sexually transmitted co-infections are common, most commercial assays target one or a few STIs. The HPV-STI ChapterDx Next Generation Sequencing (NGS) assay detects and quantifies 29 HPVs and 14 other STIs in a single-tube and single-step PCR reaction and can be applied to tens to thousands of samples in a single sequencing run. The assay was evaluated in this study, and the limit of detection was 100% at 50 copies for all targets, and 100%, 96%, 88% at 20 copies for 34, 8, and 1 target, respectively. The performance of this assay has been compared to Roche cobas HPV test, showing an overall agreement of 97.5% for hr-HPV, and 98.5% for both, HPV16 and HPV18. The assay also detected all HPV-infected CIN2/3 with 100% agreement with Roche cobas HPV results. Moreover, several co-infections with non-HPV STIs, such as C. trachomatis, T. vaginalis, M. genitalium, and HSV2 were identified. The ChapterDx HPV-STI NGS assay is a user-friendly, easy to automate and cost-efficient assay, which provides accurate and comprehensive results for a wide spectrum of HPVs and STIs.