bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weighted Gene Co-expression Network Analysis Reveals ALDH1B1 As a Prognositc Biomarker Involved in Gastric Cancer Development
Authors: Li Yi , Pu Ke , Wang Yuping , Zhou Yongning 
Published: November 2021

Abstract
BackgroundGastric cancer (GC) is one of the leading cancers associated with high mortality and poor prognosis mainly due to its relatively late diagnosis and the limited therapeutic options. Consequently, screening for prognostic GC biomarkers and novel molecular therapeutic targets is necessary to promote patient outcomes. Methods Weighted gene co-expression network analysis (WGCNA), a systems biology approach, was applied to analyze the mRNA sequencing data and clinical information of GC patients obtained from The Cancer Genome Atlas (TCGA). Gene modules and clinical traits were constructed according to the Pearson correlation analysis, and the gene ontology (GO) and functional enrichment analysis of meaningful modules were carried out. Hub genes from meaningful modules were screened out by two approaches: the intra-modular and protein-protein interaction (PPI) analysis methods. Next, through upstream regulatory analysis, hub genes with high connectivity degree were further validated with differential expression analysis, Kaplan-Meier survival analysis, and the Cox regression model. ResultsWe found that seven modules were associated with the following clinical traits: anatomical location of gastric adenocarcinoma, histological type, histological grade, and pathological stage. The hub gene ALDH1B1 was found to have potential as a biomarker for gastric cancer cells, the relationship between this hub gene and gastric cancer drug treatment is also worthy of attention.Conclusion These findings may contribute to understanding the GC tumourigenic mechanisms, as well as provide new potential prognostic factors and molecular therapeutic targets for GC. The ALDH1B1 hub gene also provides a new vantage point for further clinical experiments and large-scale cohort studies to validate its association with GC patient survival, and provide a new direction for the research of gastric cancer drug treatment.
Efficacy of Levamisole with Standard Care Treatment vs Standard Care in Clinical Presentations of Non-Hospitalized Patients with COVID-19: A Randomized Clinical Trial
Authors: Asgardoon Mohammad Hossein , koochak Hamid Emadi , Kazemi-Galougahi Mohammad Hassan , Dehnavi Ali Zare , Khodaei Behzad , Behkar Atefeh , Dehpour Ahmad Reza , Khalili Hossein , Aminianfar Mohammad 
Published: November 2021

Abstract
Introduction:

Levamisole (LVM) demonstrated clinical benefit in a trial in patients with mild to moderate coronavirus disease 2019 (COVID-19), but its effect in a larger sample size needs to be confirmed.
Methods

In this randomized open-label trial, we enrolled non-hospitalized patients with mild to moderate COVID-19 at nine health centers in Tehran province, Iran, in 2021. Patients were randomly assigned to receive a 10-day course of LVM with standard care (n = 185), or standard care (n = 180) in a 1:1 ratio. On days 1 to 10, LVM was administered orally at a dosage of 50 mg. The participants were called and followed on days 1, 3, 5, 7, 9, and 14. The outcomes were general health condition, hospitalization rate, sign and symptoms, and adverse events (AEs). Generalized Estimating Equations model was used for analysis.
Results

Among 507 randomized patients, 473 started the experiment and received LVM in addition to standard care or received only the standard care (median age, 40 [IQR, 32-50.75] years; 164 [44.9%] women; 9.4% had diabetes, 8.8% hypertension, 1.6% cardiovascular disease), and 346 (98%) completed the trial. Compared to control group, LVM decreased the general health condition of the patients (B=-0.635; CI= -0.041, -0.329; P= 0.000). Patients in the LVM with standard care group had significantly lower odds of developing fever (OR= 0.260; 95% CI= ‎0.11‎‎3‎-0.59‎‎9‎; P = .002), chills (OR= 0.223; 95% CI= ‎‎0.07‎‎6‎-‎0.64‎‎8‎; P = 0.006), fatigue (OR= 0.576; 95% CI= ‎0.34‎‎6‎-‎0.96‎‎0‎‎; P = ‎0.034), and myalgia (OR= 0.54‎‎4‎; 95% CI= ‎0.31‎‎7‎-‎0.93‎‎2‎‎; P =0.027). During the therapy, there was no significant difference in the parameters of dyspnea, cough, diarrhea, nausea, vomiting, sore throat, hyposmia, dysgeusia, and anorexia (P > 0.05). No significant difference was observed in the rate of hospitalization. Although the intervention group had greater AEs than the control group, yet, the difference was not statistically significant.
Conclusions

LVM has clinical benefit in improving health condition of patients with mild to moderate COVID-19. Further studies are needed to confirm our findings.
Trial Registration:

Iranian Registry of Clinical Trials: IRCT20201124049480N1; Registration date: 28/03/2021.
Utilization of Zinc-Ferrite/ Water Hybrid Nanofluids for enhancing thermal performance of a Flat Plate Solar Collector -An Analytical Study
Authors: stalin Prakasam Michael Joseph , Arjunan Thottipalayam Vellingri , Almeshaal Mohammed Abdulrahman , Murugesan Palaniappan , Prabu Balaramachandran , Kumar Pasupathi Manoj 
Published: November 2021

Abstract
Thermodynamic performance analysis is carried out on a flat plate solar thermal collector utilizing single and hybrid nanofluids. As heat transfer fluids, Fe2O4/water, Zn-Fe2O4/water hybrid nanofluids, and water are used, and its performance are compared based on the energy and exergy transfer rate. The thermo-physical properties are evaluated by regression polynomial model for all the working fluids. Developed codes in MATLAB solve the collector's thermal model iteratively, energy and exergetic performance are evaluated. The system was then subjected to parametric investigation and optimization for variations in fluid flow rate, temperatures, and concentrations of nanoparticles. The findings show that utilizing Zn-Fe2O4/water hybrid nanofluids with a particle concentration of 0.5 percent enhanced the solar collector's thermal performance by 6.6% while using Fe2O4/water nanofluids raised the collector's thermal performance by 7.83% when compared to water as the working fluid. While hybrid nanofluids give a better thermal alternative than water and single nanofluids, they have also produced a 5.36% increase in exergetic efficiency and an enhancement of 8.24 percent when used with Fe2O4/water nanofluids.
An Efficient and Flexible Window Function for Memristor Model and its Analog Circuit Application
Authors: singh chandra prakash 
Published: November 2021

Abstract
The memristor is a nanostructure resistive tuning two terminal novel electronics device that has been widely explored in the area of neuromorphic computing systems, memories, digital circuits, analog circuits and many more new applications. In this article an efficient and flexible window function is presented for linear drift memristor model. Propose window function provides a unique feature (controllable window function discontinuity) to linear drift memristor model by which DPHL (Distorted Pinched Hysteresis Loop) problem is resolved and also improved the programming resistance state of the memristor. Five control parameters are introduced in the presented window function, in order to fix the pre-existing problem (like boundary effect, boundary lock and inflexibility) and make it more flexible. The programmable analog gain amplifier circuit is ultimately executed to instantiate the utilization of evolved memristor model.
Characterization of the Corona Discharge Treated Cotton Subsequently Applied With Biodegradable Cationic Softener
Authors: Rehan Abdul Malik , Abro Zamir Ahmed , Zeeshan Muhammad Ali , Shah Ahmer Hussain , Tariq Syed Qutaba Bin 
Published: November 2021

Abstract
In this paper, cotton fabric processed with Corona and different amounts of biodegradable cationic softener are studied. Properties such as bending length, water absorption time, and crease recovery angle are therefore measured. By increasing the amount of cationic softener, bending length is observed to be decreased and time for water absorption and crease recovery angle of the sample increased. Scanning Electron Microscopy (SEM) is carried out for the investigation of surface morphology and the micrographs revealed cracking or etching effect on the cotton fabric treated with Corona. However, Attenuated Total Reflection- Fourier Transform Infrared Spectroscopy (ATR-FTIR) analysis confirmed the chemical change on the surface of the Corona treated cotton fabric which is due to the increase of hydrophilic groups. The results also indicated that the presence of the cationic softener on the Corona treated cotton fabric improved the hydrophobicity. The judgments are in close agreement with the findings of water absorption time, bending length, and crease recovery angle.
Changing Perceptions of Macrodistributive Justice in China: A Comparative Analysis Based on CGSS2005 and CGSS2015
Authors: Hu Rong , Zeng Ziyao , Lu Zekai , Xie Ying 
Published: November 2021

Abstract
We use comparative data from CGSS2005 and CGSS2015 to explore people's changing perceptions of macrodistributive justice in China. Despite the widening income gap, the public's recognition of distribution justice has increased. Significant economic growth has improved people's tolerance for income differentiation and helps to explain the stability of the social structure in China. However, potential benefit differentiation, status changes, intergenerational differences, values and other factors have greatly increased the disequilibrium of justice perceptions.
The Role of Children’s Age and Gender, and Friends’ Gender in the Children’s Interaction towards Social Problem Solving Strategies in Preschool Children
Authors: Izzaty Rita Eka 
Published: November 2021

Social problem-solving strategy accepted by society is the essential accomplishments in the development of pre-school children. However, until recent studies, social problem-solving strategies among pre-school children in Indonesia is still rarely conducted. This research examines the role of age, gender in children, and friends’ gender towards social problem-solving strategies. This research utilised a purposive sampling that voluntarily involved 162 children 4-6 years old. Those children were selected from an intact family consisting of a father, mother and children who lived together. A hypothetical social situation dilemma was utilised to gather social problem-solving strategies data from the subjects. The data were analysed with the use of cross-tabulation and chi-square test. Concerning the data analysis, the results reveal no significant difference in social problem-solving strategies when viewed in terms of age and gender of the children and friends’ gender. This suggests that children ages 4 to 6 years for boys and girls still have the same patterns of social behaviour dealing with similar gender and different ones.
The magnetic field about a three-dimensional block neodymium magnet
Authors: Weir Graham John , Chisholm George , Leveneur Jerome 
Published: November 2021

Neodymium magnets were independently discovered in 1984 by General Motors and Sumitomo. Today, they are the strongest type of permanent magnets commercially available. They are the most widely used industrial magnets with many applications, including in hard disk drives, cordless tools and magnetic fasteners. We use a vector potential approach, rather than the more usual magnetic potential approach, to derive the three-dimensional (3D) magnetic field for a neodymium magnet, assuming an idealized block geometry and uniform magnetization. For each field or observation point, the 3D solution involves 24 nondimensional quantities, arising from the eight vertex positions of the magnet and the three components of the magnetic field. The only unknown in the model is the value of magnetization, with all other model quantities defined in terms of field position and magnet location. The longitudinal magnetic field component in the direction of magnetization is bounded everywhere, but discontinuous across the magnet faces parallel to the magnetization direction. The transverse magnetic fields are logarithmically unbounded on approaching a vertex of the magnet.

doi:10.1017/S1446181120000097
Personas for Better Targeted eHealth Technologies: User-Centered Design Approach
Authors: ten Klooster Iris , Wentzel Jobke , Sieverink Floor , Linssen Gerard , Wesselink Robin , van Gemert-Pijnen Lisette 
Published: November 2021

Background
The full potential of eHealth technologies to support self-management and disease management for patients with chronic diseases is not being reached. A possible explanation for these lacking results is that during the development process, insufficient attention is paid to the needs, wishes, and context of the prospective end users. To overcome such issues, the user-centered design practice of creating personas is widely accepted to ensure the fit between a technology and the target group or end users throughout all phases of development.

Objective
In this study, we integrate several approaches to persona development into the Persona Approach Twente to attain a more holistic and structured approach that aligns with the iterative process of eHealth development.

Methods
In 3 steps, a secondary analysis was carried out on different parts of the data set using the Partitioning Around Medoids clustering method. First, we used health-related electronic patient record data only. Second, we added person-related data that were gathered through interviews and questionnaires. Third, we added log data.

Results
In the first step, 2 clusters were found, with average silhouette widths of 0.12 and 0.27. In the second step, again 2 clusters were found, with average silhouette widths of 0.08 and 0.12. In the third step, 3 clusters were identified, with average silhouette widths of 0.09, 0.12, and 0.04.

Conclusions
The Persona Approach Twente is applicable for mixed types of data and allows alignment of this user-centered design method to the iterative approach of eHealth development. A variety of characteristics can be used that stretches beyond (standardized) medical and demographic measurements. Challenges lie in data quality and fitness for (quantitative) clustering.
Implementing Automated Text Messaging for Patient Self-management in the Veterans Health Administration: Qualitative Study Applying the Nonadoption, Abandonment, Scale-up, Spread, and Sustainability Framework
Authors: Yakovchenko Vera , McInnes D Keith , Petrakis Beth Ann , Gillespie Chris , Lipschitz Jessica M , McCullough Megan B , Richardson Lorilei , Vetter Brian , Hogan Timothy P 
Published: November 2021

Background
The Veterans Health Administration (VHA) is deploying an automated texting system (aTS) to support patient self-management.

Objective
We conducted a qualitative evaluation to examine factors influencing national rollout of the aTS, guided by the Nonadoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) framework, which is intended to support the evaluation of novel technologies.

Methods
Semistructured interviews were conducted with 33 staff and 38 patients who were early adopters of the aTS. Data were analyzed following deductive and inductive approaches using a priori codes and emergent coding based on the NASSS.

Results
We identified themes across NASSS domains: (1) Condition: The aTS was considered relevant for a range of patient needs; however, perceptions of patient suitability were guided by texting experience and clinical complexity rather than potential benefits. (2) Technology: Onboarding of the aTS presented difficulty and the staff had different opinions on incorporating patient-generated data into care planning. (3) Value: Supply-side value relied on the flexibility of the aTS and its impact on staff workload whereas demand-side value was driven by patient perceptions of the psychological and behavioral impacts of the aTS. (4) Adopters: Limited clarity on staff roles and responsibilities presented challenges in incorporating the aTS into clinical processes. (5) Organization: Staff were willing to try the aTS; however, perceptions of leadership support and clinic readiness hindered usage. (6) Wider system: Staff focused on enhancing aTS interoperability with the electronic medical record. (7) Embedding and adaptation over time: The interplay of aTS versatility, patient and staff demands, and broader societal changes in preferences for communicating health information facilitated aTS implementation.

Conclusions
VHA’s new aTS has the potential to further engage patients and expand the reach of VHA care; however, patients and staff require additional support to adopt, implement, and sustain the aTS. The NASSS highlighted how the aTS can be better embedded into current practices, which patients might benefit most from its functionality, and which aspects of aTS messages are most relevant to self-management.

Trial Registration
ClinicalTrials.gov NCT03898349; https://clinicaltrials.gov/ct2/show/NCT03898349
Modeling Access Across the Digital Divide for Intersectional Groups Seeking Web-Based Health Information: National Survey
Authors: Medero Kristina , Merrill Jr Kelly , Ross Morgan Quinn 
Published: November 2021

Background
The digital divide refers to technological disparities based on demographic characteristics (eg, race and ethnicity). Lack of physical access to the internet inhibits online health information seeking (OHIS) and exacerbates health disparities. Research on the digital divide examines where and how people access the internet, whereas research on OHIS investigates how intersectional identities influence OHIS. We combine these perspectives to explicate how unique context–device access pairings operate differently across intersectional identities—particularly racial and ethnic groups—in the domain of OHIS.

Objective
This study aims to examine how different types of internet access relate to OHIS for different racial and ethnic groups. We investigate relationships among predisposing characteristics (ie, age, sex, education, and income), internet access (home computer, public computer, work computer, and mobile), health needs, and OHIS.

Methods
Analysis was conducted using data from the 2019 Health Information National Trends Survey. Our theoretical model of OHIS explicates the roles of internet access and health needs for racial and ethnic minority groups’ OHIS. Participant responses were analyzed using structural equation modeling. Three separate group structural equation modeling models were specified based on Black, Latine, and White self-categorizations.

Results
Overall, predisposing characteristics (ie, age, sex, education, and income) were associated with internet access, health needs, and OHIS; internet access was associated with OHIS; and health needs were associated with OHIS. Home computer and mobile access were most consistently associated with OHIS. Several notable linkages between predisposing characteristics and internet access differed for Black and Latine individuals. Older racial and ethnic minorities tended to access the internet on home and public computers less frequently; home computer access was a stronger predictor of OHIS for White individuals, and mobile access was a stronger predictor of OHIS for non-White individuals.

Conclusions
Our findings necessitate a deeper unpacking of how physical internet access, the foundational and multifaceted level of the digital divide, affects specific racial and ethnic groups and their OHIS. We not only find support for prior work on the digital divide but also surface new insights, including distinct impacts of context–device access pairings for OHIS and several relationships that differ between racial and ethnic groups. As such, we propose interventions with an intersectional approach to access to ameliorate the impact of the digital divide.
30-Year Cardiovascular Disease in Type 1 Diabetes: Risk and Risk Factors Differ by Long-term Patterns of Glycemic Control
Authors: Miller Rachel G. , Orchard Trevor J. , Costacou Tina 
Published: November 2021

OBJECTIVE
We hypothesized that there is heterogeneity in long-term patterns of glycemic control with respect to cardiovascular disease (CVD) development in type 1 diabetes and that risk factors for CVD differ by glycemic control pattern. Thus, we estimated associations between data-derived latent HbA1c trajectories and 30-year CVD risk in the Pittsburgh Epidemiology of Diabetes Complications (EDC) study of childhood-onset (&lt;17 years old) type 1 diabetes.

RESEARCH DESIGN AND METHODS
Participants (n = 536 with two or more HbA1c measurements [median 6] and CVD-free at baseline; mean age 27 and diabetes duration 18 years) were followed from 1986 to 1988 to 2016 to 2018 to ascertain CVD incidence (CVD death, myocardial infarction, stroke, coronary revascularization or blockage ≥50%, ischemic electrocardiogram, or angina). Latent HbA1c trajectories and their association with time-to-CVD incidence were simultaneously assessed using joint latent class mixed models.

RESULTS
Two HbA1c trajectories with respect to differential CVD risk were identified: low (HbA1c ∼8% [64 mmol/mol] and improving over follow-up, 76% of cohort) and high (HbA1c ∼10% [86 mmol/mol] and stable, 24%). Overall, 30-year CVD incidence was 47.4% (n = 253); major adverse cardiovascular event incidence was 31.0% (n = 176). High HbA1c was associated with threefold increased CVD risk versus low HbA1c. Both groups had similar age and diabetes duration. Non-HDL cholesterol and estimated glomerular filtration rate were associated with CVD risk only in low HbA1c; albumin excretion rate was associated with CVD risk only in high HbA1c.

CONCLUSIONS
These risk factor differences suggest that pathways to CVD may differ by glycemic control, potentially resulting in important implications for prognosis in type 1 diabetes.
METEORIC IRON IN PRODUCTION AND RELIGIOUS PRACTICE OF THE YAMNAYA CULTURE IN THE URALS REGION
Authors: Моргунова Н. Л. , Кулькова М. А. , Кульков А. М. 
Published: November 2021

Среди курганов ямной культуры Среднего Поволжья и Южного Приуралья особое место занимают монументальные сооружения с находками изделий из железа. Выделяются предметы как производственного, так и ритуального назначения. По данным радиоуглеродного анализа курганы датируются в пределах первой половины III тыс. до н. э. В 2019 г. авторами на современном оборудовании проведены новые исследования химического состава поверхности металлических предметов, изотопный анализ свинца, а также реставрация железных предметов. Дополнительные исследования позволили подтвердить метеоритное происхождение железа, уточнить форму и функциональное назначение изделий. Анализ погребального обряда и инвентаря из меди и метеоритного железа позволяет сделать вывод, что курганы были предназначены для «супер-лидеров». При жизни они могли выполнять управленческие, военные и сакрально-ритуальные функции. Наличие предметов из железа свидетельствует об обожествлении власти вождей и о распространенном представлении связи лидерства и небесных сил.
Large burial constructions that have yielded items made from iron occupy a special place among the Yamnaya kurgans in the Middle Volga region and the Southern Urals. It is possible to single out both production items and artifacts used for religious purposes. The radiocarbon data put the kurgans around the first half of III mill. BC. In 2019 the authors conducted new research of the chemical composition of the metal item surface, using modern equipment, performed the stable isotope analysis of the lead and carried out the restoration works of the iron objects. The additional studies provided an opportunity to confirm the meteoric origin of the iron, clarify the shape and the functional purpose of the artifacts. It can be inferred from the analysis of the funerary rite and the offerings made from copper and meteoric iron that the kurgans were intended to bury super leaders. During their lifetime such chieftains could perform management, military and sacral ritual functions. Presence of iron items suggests that the power of the chieftains was deified and the idea of the links between the leadership and heavenly forces was quite common.