bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Updated Review on the Therapeutic, Diagnostic, and Prognostic
Value of Long Non-Coding RNAs in Gastric Cancer
Authors: Mohammadzadeh Alemeh , Dastmalchi Narges , Hussen Bashdar Mahmud , Shadbad Mahdi Abdoli , Safaralizadeh Reza 
Published: November 2021

:
As a novel group of non-coding RNAs, long non-coding RNA (lncRNAs) can
substantially regulate various biological processes. Downregulated tumor-suppressive
lncRNAs and upregulated oncogenic lncRNAs (onco-lncRNAs) have been implicated in
gastric cancer (GC) development. These dysregulations have been associated with decreased
chemosensitivity, inhibited apoptosis, and increased tumor migration in GC. Besides,
growing evidence indicates that lncRNAs can be a valuable diagnostic and prognostic
biomarker, and their expression levels are substantially associated with the clinicopathological
features of affected patients. The current study aims to review the recent
findings of the tumor-suppressive lncRNAs and onco-lncRNAs in GC development and
highlight their therapeutic, diagnostic, and prognostic values in treating GC cells. Besides,
it intends to highlight the future direction of lncRNAs in treating GC.
Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
Authors: Goyal Shweta , Seth Brashket , Chaturvedi Rajnish K. 
Published: November 2021

:Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) are neurological disorders pathologically characterized by chronic degeneration of dopaminergic neurons and motor neurons, respectively. There is still no cure or effective treatment against the disease progression and most of the treatments are symptomatic. The present review offers an overview of the different factors involved in the pathogenesis of these diseases. Subsequently, we focused on the recent advanced studies of dietary polyphenols and stem cell therapies, which have made it possible to slow down the progression of neurodegeneration. To date, stem cells and different polyphenols have been used for the directional induction of neural stem cells into dopaminergic neurons and motor neurons. We have also discussed their involvement in the modulation of different signal transduction pathways and growth factor levels in various in vivo and in vitro studies. Likewise stem cells, polyphenols also exhibit the potential of neuroprotection by their anti-apoptotic, anti-inflammatory, and anti-oxidant properties regulating the growth factors levels and molecular signaling events. Overall this review provides a detailed insight into recent strategies that promise the use of polyphenol with stem cell therapy for the possible treatment of PD and ALS.
Update on Myositis Therapy: From Today’s Standards to Tomorrow’s Possibilities
Authors: Glaubitz Stefanie , Zeng Rachel , Rakocevic Goran , Schmidt Jens 
Published: November 2021

Abstract:
Inflammatory myopathies, in short, myositis, are heterogeneous disorders that are characterized by
inflammation of skeletal muscle and weakness of arms and legs. Research over the past few years has led to a
new understanding regarding the pathogenesis of myositis. The new insights include different pathways of the
innate and adaptive immune response during the pathogenesis of myositis. The importance of non-inflammatory
mechanisms such as cell stress and impaired autophagy has been recently described. New target-specific
drugs for myositis have been developed and are currently being tested in clinical trials. In this review, we discuss
the mechanisms of action of pharmacological standards in myositis and provide an outlook of future treatment
approaches.
Biosynthesized CdS Nanoparticle Induces ROS-dependent Apoptosis in Human Lung
Cancer Cells
Authors: Shaikh Soni , Nasrin Tina , Patra Mousumi , Rahaman Sayed Modinur , Das Tapan Kumar 
Published: November 2021

Background:
The World Health Organization (WHO) estimated that the number of cancer-related deaths
was 9.6 million in 2018 and 2.09 million deaths occurred by lung cancer. The American Institute for Cancer Research
(AICR) also observed gender preferences in lung cancer, common in men than women. Since the past decade, nanoparticles
have now been widely documented for their anti-cancer properties, which signifies that the development of
nanotechnology would be a future diagnosis and treatment strategy for lung cancer.

Objective:
The current study aimed to investigate the role of biosynthesized CdS nanoparticles (CdS NPs) in lung
cancer cells (A549). Therefore, whether the CdS NP induces lung cancer cell death and the underlying mechanism is
yet to be elucidated.

Methods:
Literature was searched from various archives of biomedical and life science journals. Then, CdS NPs were
biosynthesized and characterized by traditional and cutting-edge protocols. The CdS NP-mediated cell death was elucidated
following standard protocols.

Results:
CdS NPs induced cytotoxicity towards A549 cells in a dose-dependent manner. However, such a death
mechanism does not go through necrosis. Intracellular reactive oxygen species (ROS) accumulation and mitochondrial
membrane depolarization demonstrated that cell death is associated with intracellular ROS production. Furthermore,
increased sub-G1 population, Bax expression, and decreased Bcl-2 expression revealed that the death was caused by
apoptosis.

Conclusion:
CdS NPs promote apoptosis-mediated lung cancer cell death through ROS production.
Relasi kuasa dalam pengembangan perangkat lunak open source perpustakaan perguruan tinggi di Bali
Authors: Suhartika I Putu , Haryanti Ni Putu Premierita 
Published: November 2021

Introductions. Discussions on critical perspectives of open source software is limited as most studies focus on technical aspects. This study examines aspects of process, form, ideology, and implications of power relations in the development of open source software for university libraries in Bali, observed from non-technical aspects of the system.
Research methods. The paper used cultural studies method with semi-structured interviews, observation, and documentation as data collection methods.
Data analysis. This study used genealogy and deconstruction methods involving Foucault and Derrida theory.
Results and discussion. The process of power relations in the development of open source software for university libraries in Bali is not only comes in parallel, but also in hegemonic relations. These relations are based on knowledge and influenced by the ideology of librarianship, free, open source, and capitalist which have implications for libraries, librarians, and users.
Conclusions and suggestions. The practice of power relations in the development of open source software for university libraries in Bali occurred through knowledge and hegemonic power. Therefore, human resources should also improve their communication skills.
Effects of Trauma and Anxiety on Adherence in Pediatric Type 1 Diabetes
Authors: Raj Rishi , Nguyen Mai , Pozzo Alba Morales , Marsac Meghan L. , Vselvoshakaya Olga , Meadows Amy Lynn 
Published: November 2021

BackgroundPsychiatric factors such as depression, anxiety, and life stressors have been shown to negatively affect diabetes self-management and A1C in children and adolescents. However, less is known about how trauma exposure and symptoms of post-traumatic stress disorder (PTSD) may affect type 1 diabetes.ObjectivesTo determine the rates of trauma exposure and PTSD symptoms in patients aged 7–21 years with type 1 diabetes and to examine the relationships among trauma exposure, PTSD, anxiety, depression, and diabetes self-management.MethodsPatients underwent standardized psychiatric screening questionnaires during clinic visits. A1C at goal was defined as &lt;7.0%, and behavioral adherence was defined as specific parameters of blood glucose monitoring. χ2 and Fisher exact tests were used to assess the relationships among trauma, PTSD, anxiety, and behavioral adherence. ANOVA was conducted to examine group differences between A1C and the presence of suicidal ideation.ResultsOf the participants, 38.4% (n = 99, mean age 13.8 ± 3.5 years, 51.5% female) had trauma symptoms and functional impairment concerning for PTSD. Rates of trauma secondary to accidental injury, medical traumatic stress, natural disaster, and witness to family violence were 28.3, 22.2, 10.1, and 6.1%, respectively. Neither PTSD nor anxiety nor depression symptoms were associated with behavioral nonadherence (P = 0.546, P = 0.337, and P = 0.697, respectively), but the subscales for significant school avoidance and generalized anxiety disorders were associated with behavioral nonadherence (P = 0.023 and P = 0.032, respectively). Those who reported suicidal ideation had higher mean A1C than those who did not (A1C 8.9 vs. 8.3, P = 0.047).ConclusionAlthough trauma was common among youth with type 1 diabetes, neither trauma nor PTSD was associated with changes to self-management. However, certain forms of anxiety and suicidal ideation were associated with poor self-management and higher A1C, respectively.
Reading the Silence of Bengi in Arupa Patangia’s ‘Aai’
Authors: Dutta Kalita Sandhani 
Published: November 2021

Arupa Patangia’s Aai, tells the story of Pomeela Bengi, a dim witted imbecile who has been a victim of the insurgency and has been rendered invisible after the death of her only surviving son Mohan. But, her silence acted as a voice of resistance because through it she could powerfully express how the state and its mechanisms function and makes the ordinary people like Pomeela victims, and how they are searching for an alternative.
A Testament to the Power of Resilience and Friendship Portrayed in Stephen King’s The Institute
Authors: Manju Dr. A.J , P M Anas 
Published: November 2021

We all face Hardships and difficult situations in our life. It’s all about the ups and downs in our day to day life. During these times we may be feeling exhausted and worried. But all that matters is that what we have learned from that tough situation. Resilience is defined as how we bounce back quickly from a difficult situation. The power of resilience arises when we face situational problems, major life problem and day to day problems. Friends are a major element in comforting us during our difficult times. Friends bring more happiness to our lives than virtually anything else. Friendships have a huge impact on our mental health and happiness. Good friends relieve stress, provide comfort and joy, and prevent loneliness and isolation.
The Institute (2019) is a science fiction horror novel written by Stephen king. It is one of his terrifying novels yet. Many of his works are transformed into movies and television series. The main focus of this novel is on the power of resilience and friendship among the children who are being kidnapped from their homes and being held captive under a sinister establishment called The Institute. The story is written by taking the ideas of a fictitious child abusing institution where gifted children from all over the country are taken in and they are being forced to undergo atrocious medical experiments. Most of the children have super powers of Telepathy or Telekinesis. That’s the reason they are all here in the Institute. The authorities in the Institute want the children to master their powers so that they can be used in wars. There is no hope of escape for the children, yet they are all finally escaped by the power of resilience and friendship shown by Luke Ellis, the main character in the novel and his friends.
The Impact of Outdoor Education Camp Program in Building Resilience among University Students
Authors: Samsudin Shamsulariffin , Tengku Kamalden Tengku Fadilah , Aziz Azlizam , Ismail Mohd Hafizal , Yaakob Sam Shor Nahar , Farizan Noor Hamzani 
Published: November 2021

Abstract: Resilience is gained through life experiences that local university students lack from a classroom environment. This study investigated the effect of outdoor education camp programs on the levels of resilience among Physical Education students from two selected universities in Malaysia. A questionnaire was utilized as the primary research tool in this study to assess the participants' perceptions and knowledge acquisition as well as their level of resilience toward the outdoor education camp programs. A total of 162 undergraduate students were studied using a pre-test and post-test approach and a modified version of the Connor-Davidson in a 25 items self-report scale. Analysis of paired t-test showed differences in factors involved in resilience variables, personal competence, instincts and tolerance of negative behavior, positive acceptance of change, control, and spiritual influence. The findings indicated a positive effect towards resilience upon completion of the 14-day outdoor education camp program. A multivariate analysis of variance (MANOVA) was carried out to evaluate if participation in the outdoor education program influenced participants' perceived level of resilience. Overall, there were statistically significant increases in resilience levels from the pre-test to the post-test stage. These results lead to the need for in-depth research into the assessment of internal factors in an outdoor camp program to provide valuable information on the effect of the intervention and implications towards enhancing resilience of the participants in low to high-risk activities.

Keywords: Outdoor education, Personal Development, Program Evaluation, Physical Education, Resilience
The Use of Video Annotation in Education: A Review
Authors: Catherine Chui Lam Nguoi , Habil Hadina 
Published: November 2021

Abstract: Video annotation (VA), a tool which allows commentaries to be synchronized with video content has recently received significant research attention in education. However, the application contexts of these studies are varied and fragmented. A review was therefore undertaken with the objectives to find out the extent to which the use of VA has been explored for different instructional purposes and summarize the potential affordances of VA in supporting student learning. Articles related to the use of VA in education context were searched from 2011 to 2020 (Nov). Of the final 32 eligible studies, it was found that VA tools were used predominantly to develop teaching practices, enhance learners’ conceptual understanding of video content and develop workplace skills as well as clinical practices. Five most dominant educational affordances of VA tools were summarized as follows: (1) facilitating learners’ reflection (2) facilitating feedback process (3) enhancing comprehension of video content (4) promoting students’ learning satisfaction and positive attitude and (5) convenience and ease. With the outstanding weight of research evidence gained on educational affordances offered by VA, it is convincing that advancing the use of VA in education can further expand the learning opportunities in 21st century classrooms.

Keywords: Affordances, Education, Feedback, Learners’ reflection, Video annotation
After a Year of Online Learning Amid the COVID-19 Pandemic: A Survey of Indonesian Undergraduate Students' Opinions and Behaviors
Authors: Prabawangi R. Prita , Fatanti Megasari Noer , Ananda Kun Sila 
Published: November 2021

Abstract: Universities around Indonesia are currently adopting online lectures to keep the learning process running in the face of the COVID-19 outbreak. Online courses, thanks to the rapid advancement of ICT, allow students and lecturers to interact despite the stay-at-home policy. Because of its flexibility and modern lifestyle, this method is likely to continue to be used in the future. Therefore, this study examines the benefits and disadvantages of online learning and understands students' expectations. With a total sample of 226 undergraduate students from four cities and seven universities in Indonesia, this research uses a descriptive survey design. The data collection technique was an online survey using Google Forms during May and June 2021. The results showed that most students viewed online learning during the pandemic as going well, although some students felt that their academic needs were not being met. Students find benefits of online learning, such as flexibility, cost savings, and increased confidence in engaging in discussions. However, the respondents identified a number of obstacles to achieve the ideal learning process, including low signal quality, limited laboratory practices, and high internet network expenses. Students reported certain disadvantages of online learning, such as limited interaction, irregular class schedules, and a high number of assignments. This study also found that most students lose their concentration easily. They also multitask during synchronous learning, where the side activities are mostly academically unrelated (e.g., doing daily activities, scrolling through social media, driving, and watching movies). From the data gathered, it is important for lecturers and universities to consider the reduction in assignments, meeting frequency, and duration of online learning to maintain students’ motivation and concentration

Keywords: Covid-19, higher education, Indonesia, online learning, undergraduate students
Measuring Satisfaction on Augmented Reality Courseware for Hearing-Impaired Students: Adjustment Formula form SUS
Authors: Megat Mohd Zainuddin Norziha , Maarop Nurazean , Wan Hassan Wan Azlan 
Published: November 2021

Abstract: Satisfaction is an important usability attribute in developing a courseware which involves end users. Measuring satisfaction among hearing-impaired students is different than measuring it among common students because they learn using sign language and have different learning styles. An educational courseware for hearing-impaired students is employed to measure this. The courseware uses the Augmented Reality technology and it is called PekAR-Mikroorganisma. Hence, this article focuses on the methodology of measuring and the attributes that contribute to users’ satisfaction. An adaptation of the System Usability Scale was used to identify the satisfaction value. Fifteen hearing-impaired students were employed as a case study. Findings show that the satisfaction level in using PekAR Mikroorganisma is high. It is hoped PekAR-Mikroorganisma can help the hearing-impaired to understand lessons better through the enhancement of their comprehension on abstract concepts.

Keywords: Augmented Reality, Hearing-Impaired, Usability Testing, Visual Informatics
The Effectiveness of Industrial Training during Covid- 19 Pandemic: Perspective of Undergraduate Students of Mechanical Engineering
Authors: Nik Roseley Nik Roselina , Kasolang Salmiah , S.K. Amedorme , Saad Nor Hayati , Venkatason Kausalyah , Makhsin Siti Rabizah 
Published: November 2021

Abstract: A post-training survey was conducted to all students of Bachelor of Engineering (Hons) Mechanical programme in Universiti Teknologi MARA (UiTM) who completed their industrial training in 2020. The aim of the survey was to overview the effectiveness of industrial training in the perspective of students. This study also was carried out to investigate the effect Covid-19 pandemic on the preparation of companies and students’ perception of their own performance before and after the industrial training. The survey was conducted via online involving 166 respondents. The questions included multiple-choice, 5-score Likert scale and open-ended questions. The results show that the majority of the respondents were satisfied with their selection of placement and achievement during the training with the highest mean Likert score of 4.65. The analysis on the self-evaluation of performance before and after industrial training also revealed a significant increase in generic skills especially personal attitude and professionalism aspects. The finding of this work also concludes that the pandemic has no severe impact on the effectiveness of industrial training in the perspective of the students. This finding will be considered for the development of guidelines of Industrial Training course to fit the demands during the pandemic.

Keywords: Industrial Training, Mechanical Engineering, Performance, Survey
Student Satisfaction in Using a Learning Management System (LMS) for Blended Learning Courses for Tertiary Education
Authors: Mohd Nasir Farah Damia , Hussain Mohd Al Mahdi , Mohamed Harnani , Mohd Mokhtar Mohd Amar , Abdul Karim Noorhuda 
Published: November 2021

Abstract: This study aims to investigate factors associated with students’ satisfaction with using LMS - UNIEC Virtual in blended learning courses in UNITAR International University, Kelana Jaya. Three factors; perceived ease of use (PEOU), facilitating conditions, and interaction are selected as independent variables in this study. This research was designed using a quantitative method with 17 closed-ended items questions with a 5-Likert scale and one open-ended question. The questionnaire was developed and modified from a published instrument and previous literature. 70 students were selected from Semester 3, Faculty of Education and Humanities by using cluster sampling. From the data analysis using Spearman Coefficients, there is a statistically significant correlation between facilitating conditions, perceived ease of use, and interaction on student satisfaction on using LMS. Results showed that in perceived ease of use (PEOU), participants agreed that they can easily access UNIEC Virtual features without any training and were confident of their computer skills to perform the task on UNIEC Virtual. As for the facilitating conditions, results showed that the students were able to navigate through the items on the website interface without difficulty. On the other hand, students suggested having a tutorial on how to use UNIEC integrated features, such as Office365 mail. Regarding the facilitating conditions, the students feel that course notes, forums, and assignments on UNIEC Virtual helped them to achieve a better learning outcome. They enjoyed participating in the discussion forum as well as creating ways to interact with the course mates and lecturers.

Keywords: UNIEC Virtual, Learning Management System (LMS), blended learning, perceived ease of use (PEOU), facilitating conditions and interaction.
Implementation Of LMS-CIDOS In Polytechnic English Language Classroom: Issues And Challenges
Authors: Hasnan Mahanim , Mohin Mohaida 
Published: November 2021

Abstract: The wide implementation of the Learning Management System (LMS) in many Higher Education Institutions (HEIs) in Malaysia is seen as strong support for eLearning. Many LMS have been developed and adopted based on their features, usability and functionality that can offer benefits for the whole faculty of the institution. In Malaysia’s Polytechnic, LMS-CIDOS is a platform used for eLearning. A blended learning platform has become a need for many lecturers. This study investigated the perception of English Language lecturers in utilising the platform to implement eLearning in language classroom teaching. This study explored the issues and challenges in implementing the blended learning concept in Muadzam Shah Polytechnic. The lecturers’ perceptions in this study were measured using the Instructors LMS Acceptance Model proposed by Kamla and Hafedh (2010), which was modified from the original Technology Acceptance Model (TAM) by Davis (1989). Seven experienced English Language Lecturers were also interviewed using the semi-structured interview approach. Among the themes that emerged through the thematic analysis was the reliability of hardware, software & internet connection, design and content organisation, temporary record-keeping, complex system structure, inadequate time and work management, insufficient training and support from the institution, the need for teaching guide from the expert, lack of skills to encourage active communication using LMS-CIDOS and students’ lack of digital literacy skills. The findings of this study offer an expanded understanding of LMS acceptance among higher education instructors and a reference for related areas of study.

Keywords: Blended learning, e-learning, LMS-CIDOS.