bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart and brain interactions
Authors: Schnabel Renate B. , Hasenfuß Gert , Buchmann Sylvia , Kahl Kai G. , Aeschbacher Stefanie , Osswald Stefan , Angermann Christiane E. 
Published: February 2021

AbstractCardiovascular diseases (CVD) and mental health disorders (MHD; e.g. depression, anxiety and cognitive dysfunction) are highly prevalent and are associated with significant morbidity and mortality and impaired quality of life. Currently, possible interactions between pathophysiological mechanisms in MHD and CVD are rarely considered during the diagnostic work-up, prognostic assessment and treatment planning in patients with CVD, and research addressing bidirectional disease mechanisms in a systematic fashion is scarce. Besides some overarching pathogenetic principles shared by CVD and MHD, there are specific syndromes in which pre-existing neurological or psychiatric illness predisposes and contributes to CVD development (as in Takotsubo syndrome), or in which the distorted interplay between innate immune and central nervous systems and/or pre-existing CVD leads to secondary MHD and brain damage (as in peripartum cardiomyopathy or atrial fibrillation). Clinical manifestations and phenotypes of cardio-psycho-neurological diseases depend on the individual somatic, psychosocial, and genetic risk profile as well as on personal resilience, and differ in many respects between men and women. In this article, we provide arguments on why, in such conditions, multidisciplinary collaborations should be established to allow for more comprehensive understanding of the pathophysiology as well as appropriate and targeted diagnosis and treatment. In addition, we summarize current knowledge on the complex interactions between the cardiovascular and central nervous systems in Takotsubo syndrome and peripartum cardiomyopathy, and on the neurological and psychiatric complications of atrial fibrillation.
Therapieoptionen beim oligometastasierten Magenkarzinom
Authors: Jung Minoa Karin , Ott Katja , Chevallay Mickael , Mönig Stefan Paul 
Published: February 2021

Zusammenfassung
Hintergrund
Zum Zeitpunkt der Diagnosestellung des Magenkarzinoms haben ca. zwei Drittel der Patienten bereits Metastasen. Wichtig ist es, die Oligometastasierung von der diffus metastasierten Situation abzugrenzen. Die S3-Leitlinie hat die Definition der Oligometastasierung erstmals in die Leitlinie aufgenommen.

Fragestellung
Kann das Überleben von Patienten mit Oligometastasierung mittels Resektion des Tumors und der Metastase kombiniert mit perioperativer Chemotherapie verbessert werden?

Material und Methoden
In dieser Übersichtsarbeit wird die Datenlage der aktuellen Literatur dargestellt.

Ergebnisse
Die holländische Magenkarzinomstudie stellte ein verbessertes medianes Überleben für Patienten mit singulären Metastasen fest, wenn diese reseziert wurden. Aufgrund der Resultate der deutschen AIO-FLOT3-Studie, in der sich das mediane Überleben von Patienten mit Oligometastasen mit multimodaler Therapie verdoppelte, wurde die AIO-FLOT5(RENAISSANCE)-Studie initiiert. Diese randomisiert limitiert metastatische Patienten nach neoadjuvanter Chemotherapie entweder zu Resektion gefolgt von Chemotherapie oder zu definitiver Chemotherapie. Weitere randomisierende Studien untersuchen den Nutzen von Antikörpern und Immun-Checkpoint-Inhibitoren beim lokoregionalen und metastasierten Magenkarzinom mit vielversprechenden Resultaten.

Diskussion
Die Resultate der aktuellen Studien werden zeigen, ob Patienten mit Oligometastasierung von einer multimodalen Therapie mit Resektion profitieren. Die eindeutige Definition der Oligometastasierung, eine Beurteilung des Ansprechens nach neoadjuvanter Chemotherapie und eine realistische Einschätzung der R0-Resektion werden bei der entsprechenden Patientenselektion hilfreich sein.
Protuberances are organized distinct regions of long-term callus: histological and transcriptomic analyses in kiwifruit
Authors: Czernicka Małgorzata , Chłosta Iwona , Kęska Kinga , Kozieradzka-Kiszkurno Małgorzata , Abdullah Mohib , Popielarska-Konieczna Marzena 
Published: February 2021

Abstract
Key message
Macroscopic, ultrastructural, and molecular features—like a ball shape, the presence of starch granules, and the up-regulation of genes involved in carbohydrate metabolism and secondary metabolite biosynthesis—distinguish PT regions within a callus.

Abstract
The modification of the mass of pluripotent cells into de novo shoot bud regeneration is highly relevant to developmental biology and for agriculture and biotechnology. This study deals with protuberances (PT), structures that appear during the organogenic long-term culturing of callus (OC) in kiwifruit. These ball-shaped regions of callus might be considered the first morphological sign of the subsequent shoot bud development. Sections of PT show the regular arrangement of some cells, especially on the surface, in contrast to the regions of OC beyond the PT. The cells of OC possess chloroplasts; however, starch granules were observed only in PTs’ plastids. Transcriptomic data revealed unique gene expression for each kind of sample: OC, PT, and PT with visible shoot buds (PT–SH). Higher expression of the gene involved in lipid (glycerol-3-phosphate acyltransferase 5 [GPAT5]), carbohydrate (granule-bound starch synthase 1 [GBSS1]), and secondary metabolite (beta-glucosidase 45 [BGL45]) pathways were detected in PT and could be proposed as the markers of these structures. The up-regulation of the regulatory associated protein of TOR (RAPTOR1) was found in PT–SH. The highest expression of the actinidain gene in leaves from two-year-old regenerated plants suggests that the synthesis of this protein takes place in fully developed organs. The findings indicate that PT and PT–SH are specific structures within OC but have more features in common with callus tissue than with organs.
The electrophysiological footprint of CACNA1A disorders
Authors: Indelicato Elisabetta , Unterberger Iris , Nachbauer Wolfgang , Eigentler Andreas , Amprosi Matthias , Zeiner Fiona , Haberlandt Edda , Kaml Manuela , Gizewski Elke , Boesch Sylvia 
Published: February 2021

Abstract
Objectives
CACNA1A variants underlie three neurological disorders: familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6). EEG is applied to study their episodic manifestations, but findings in the intervals did not gain attention up to date.

Methods
We analyzed repeated EEG recordings performed between 1994 and 2019 in a large cohort of genetically confirmed CACNA1A patients. EEG findings were compared with those of CACNA1A-negative phenocopies. A review of the related literature was performed.

Results
85 EEG recordings from 38 patients (19 EA2, 14 FHM1, 5 SCA6) were analyzed. Baseline EEG was abnormal in 55% of cases (12 EA2, 9 FHM1). The most common finding was a lateralized intermittent slowing, mainly affecting the temporal region. Slowing was more pronounced after a recent attack but was consistently detected in the majority of patients also during the follow-up. Interictal epileptic discharges (IEDs) were detected in eight patients (7 EA2,1 FHM1). EEG abnormalities and especially IEDs were significantly associated with younger age at examination (16 ± 9 vs 43 ± 21 years in those without epileptic changes, p = 0.003) and with earlier onset of disease (1 (1–2) vs 12 (5–45) years, p = 0.0009). EEG findings in CACNA1A-negative phenocopies (n = 15) were largely unremarkable (p = 0.03 in the comparison with CACNA1A patients).

Conclusions
EEG abnormalities between attacks are highly prevalent in episodic CACNA1A disorders and especially associated with younger age at examination and earlier disease onset. Our findings underpin an age-dependent effect of CACNA1A variants, with a more severe impairment when P/Q channel dysfunction manifests early in life.
Effects of Levodopa on quality of sleep and nocturnal movements in Parkinson’s Disease
Authors: Schaeffer Eva , Vaterrodt Thomas , Zaunbrecher Laura , Liepelt-Scarfone Inga , Emmert Kirsten , Roeben Benjamin , Elshehabi Morad , Hansen Clint , Becker Sara , Nussbaum Susanne , Busch Jan-Hinrich , Synofzik Matthis , Berg Daniela , Maetzler Walter 
Published: February 2021

Abstract
Background
Sleep disturbances are common in Parkinson’s Disease (PD), with nocturnal akinesia being one of the most burdensome. Levodopa is frequently used in clinical routine to improve nocturnal akinesia, although evidence is not well proven.

Methods
We assessed associations of Levodopa intake with quality of sleep and perception of nocturnal akinesia in three PD cohorts, using the Parkinson’s Disease Sleep Scale (PDSS-2) in two cohorts and a question on nocturnal immobility in one cohort. In one cohort also objective assessment of mobility during sleep was performed, using mobile health technology.

Results
In an independent analysis of all three cohorts (in total n = 1124 PD patients), patients taking Levodopa CR reported a significantly higher burden by nocturnal akinesia than patients without Levodopa. Higher Levodopa intake and MDS-UPDRS part IV scores (indicating motor fluctuations) predicted worse PDSS-2 and higher subjective nocturnal immobility scores, while disease duration and severity were not predictive. Levodopa intake was not associated with objectively changed mobility during sleep.

Conclusion
Our results showed an association of higher Levodopa intake with perception of worse quality of sleep and nocturnal immobility in PD, indicating that Levodopa alone might not be suitable to improve subjective feeling of nocturnal akinesia in PD. In contrast, Levodopa intake was not relevantly associated with objectively measured mobility during sleep. PD patients with motor fluctuations may be particularly affected by subjective perception of nocturnal mobility. This study should motivate further pathophysiological and clinical investigations on the cause of perception of immobility during sleep in PD.
Quail-chick grafting experiments corroborate that Tbr1-positive eminential prethalamic neurons migrate along three streams into hypothalamus, subpallium and septocommissural areas
Authors: Alonso Antonia , Trujillo Carmen María , Puelles Luis 
Published: February 2021

AbstractThe prethalamic eminence (PThE), a diencephalic caudal neighbor of the telencephalon and alar hypothalamus, is frequently described in mammals and birds as a transient embryonic structure, undetectable in the adult brain. Based on descriptive developmental analysis ofTbr1gene brain expression in chick embryos, we previously reported that three migratory cellular streams exit the PThE rostralward, targeting multiple sites in the hypothalamus, subpallium and septocommissural area, where eminential cells form distinct nuclei or disperse populations. These conclusions needed experimental corroboration. In this work, we used the homotopic quail-chick chimeric grafting procedure at stages HH10/HH11 to demonstrate by fate-mapping the three predicted tangential migration streams. Some chimeric brains were processed forTbr1in situ hybridization, for correlation with our previous approach. Evidence supporting all three postulated migration streams is presented. The results suggested a slight heterochrony among the juxtapeduncular (first), the peripeduncular (next), and the eminentio-septal (last) streams, each of which followed differential routes. A possible effect of such heterochrony on the differential selection of medial to lateral habenular hodologic targets by the migrated neurons is discussed.
Tropical cyclones over the western north Pacific since the mid-nineteenth century
Authors: Kubota Hisayuki , Matsumoto Jun , Zaiki Masumi , Tsukahara Togo , Mikami Takehiko , Allan Rob , Wilkinson Clive , Wilkinson Sally , Wood Kevin , Mollan Mark 
Published: February 2021

AbstractTropical cyclone (TC) activities over the western North Pacific (WNP) and TC landfall in Japan are investigated by collecting historical TC track data and meteorological observation data starting from the mid-nineteenth century. Historical TC track data and TC best track data are merged over the WNP from 1884 to 2018. The quality of historical TC data is not sufficient to count the TC numbers over the WNP due to the lack of spatial coverage and different TC criteria before the 1950s. We focus on TC landfall in Japan using a combination of TC track data and meteorological data observed at weather stations and lighthouses from 1877 to 2019. A unified TC definition is applied to obtain equivalent quality during the whole analysis period. We identify lower annual TC landfall numbers during the 1970s to the 2000s and find other periods have more TC landfall numbers including the nineteenth century. No trend in TC landfall number is detected. TC intensity is estimated by an annual power dissipation index (APDI). High APDI periods are found to be around 1900, in the 1910s, from the 1930s to 1960s, and after the 1990s. When we focus on the period from 1977 to 2019, a significant increasing trend of ADPI is seen, and significant northeastward shift of TC landfall location is detected. On the other hand, TC landfall location shifts northeastward and then southwestward in about 100-year interval. European and US ships sailed through East and Southeast Asian waters before the weather station network was established in the late nineteenth century. Then, we focus on TC events in July 1853 observed by the US Naval Japan Expedition of Perry’s fleet and August 1863 by a UK Navy ship that participated in two wars in Japan. A TC moved slowly westward over the East China Sea south of the Okinawa Islands from 21 to 25 July 1853. Another TC was detected in the East China Sea on 15–16 August 1863 during the bombardment of Kagoshima in southern Japan. Pressure data are evaluated by comparing the observations made by 10 naval ships in Yokohama, central Japan during 1863–1864. The deviation of each ship pressure data from the 10 ships mean is about 2.7–2.8 hPa.
Monitoring nitrate reduction: hydrogeochemistry and clogging potential in raw water wells
Authors: Ortmeyer F. , Volkova K. , Wisotzky F. , Wohnlich S. , Banning A. 
Published: February 2021

AbstractThe mainly agricultural input of NO3- and compliance with drinking water guideline values pose major challenges for many water suppliers. Additionally, associated changes in hydrochemistry, especially concerning products of NO3- reduction (Fe2+/3+, Mn2+/4+, Ca2+, Mg2+, SO42-, HCO3-) and subsequent reactions, can have a major influence on mineral saturation states and well yield: well productivity can be strongly reduced by mineral precipitation and silting. To evaluate hydrogeochemical evolution and clogging potential for a given well field, thorough hydrochemical and geochemical investigations are required. Therefore, time-dependent and depth-specific ion concentrations in water samples (n = 818) were analysed in a catchment area of a waterworks in western Germany. The sediments of the aquifers were extensively investigated for their geochemistry (CS, scanning electron microscope, aqua regia digestion and dithionite solution; n = 253). In addition, PhreeqC was used to model saturation indices in order to identify possible mineral precipitation in the wells. Results show a high NO3- input into deep wells screened in Tertiary sediments due to an admixture of Quaternary groundwater. Directly at the Quaternary-Tertiary boundary, chemolithotrophic NO3- reduction consuming pyrite occurs. Protons released during the process are pH-buffered by dissolving carbonate minerals. Overall, the hydrochemistry and especially the saturation indices are strongly influenced by NO3- reduction and its degradation products. A change in well yield has not yet been observed, but future clogging by ochre formation or sintering cannot be excluded.
Economic Complexity and Environmental Performance: Evidence from a World Sample
Authors: Boleti Eirini , Garas Antonios , Kyriakou Alexandra , Lapatinas Athanasios 
Published: February 2021

AbstractIn this paper, we analyze the relationship between economic complexity and environmental performance using annual data on 88 developed and developing countries for the period of 2002–2012. We use the Economic Complexity Index, which links a country’s productive structure with the amount of knowledge and know-how embodied in the goods it produces, and the Environmental Performance Index as a measure of environmental performance. We show that moving to higher levels of economic complexity leads to better overall environmental performance, which means that sophistication of exported products does not induce environmental degradation. Nevertheless, we find that the effect of economic complexity on air quality is negative, i.e., exposure to PM2.5, CO$$_2$$

2

, methane and nitrous oxide emissions increases, and these findings are robust across alternative econometric specifications.
Success of collaboration for sustainable agriculture: a case study meta-analysis
Authors: Velten Sarah , Jager Nicolas W. , Newig Jens 
Published: February 2021

AbstractMore and better collaboration between farmers and other stakeholders has repeatedly been identified as a key strategy for sustainable agriculture. However, for collaboration to actually benefit sustainable agriculture certain conditions have to be met. In this paper, we scrutinize the conditions that support or hamper the success of collaborative efforts in the context of sustainable agriculture. For this purpose, we conducted an exploratory case study meta-analysis to consolidate insights from 30 case studies on local and regional collaborative groups for a more sustainable agriculture in the EU. Through multiple regression analysis, we evaluated which factors influence the ‘success’ of such collaboratives. Thereby, we measured success through five explicit and comprehensive success criteria. We found two external, five actor-related, and five organization and management-related factors to decisively influence the different success criteria. Overall, our results highlight that collaboration success requires defining priorities as for each of the success criteria a different set of factors is decisive. Although our results showed trade-offs between the achievement of social and economic goals, it is possible to pursue some success criteria simultaneously. Furthermore, our results give reason to be optimistic about the performance of collaboratives: internal factors, which are in the hand of the collaboratives, are likely to be of greater importance than uncontrollable external conditions. Additionally, conditions encountered at the outset of a collaborative matter less than the way these conditions develop toward later stages. Thus, rather than depending on external and predefined conditions, success largely depends on the agency within the collaboratives.
Asymptotic analysis of self-excited and forced vibrations of a self-regulating pressure control valve
Authors: Schröders Simon , Fidlin Alexander 
Published: February 2021

AbstractPressure vibrations in hydraulic systems are a widespread problem and can be caused by external excitation or self-exciting mechanisms. Although vibrations cannot be completely avoided in most cases, at least their frequencies must be known in order to prevent resonant excitation of adjacent components. While external excitation frequencies are known in most cases, the estimation of self-excited vibration amplitudes and frequencies is often difficult. Usually, numerical studies have to be executed in order to elaborate parameter influences, which is computationally expensive. The same holds true for the prediction of forced oscillation amplitudes. This contribution proposes asymptotic approximations of forced and self-excited oscillations in a simple hydraulic circuit consisting of a pump, an ideal consumer and a pressure control valve. Two excitation mechanisms of practical interest, namely pump pulsations (forced vibrations) and valve instability (self-excited vibrations), are analyzed. The system dynamics are described by a singularly perturbed third-order differential equation. By separating slow and fast variables in the system without external excitation, a first-order approximation of the slow manifold is computed. The flow on the slow manifold is approximated by an averaging procedure, whose piecewise defined zero-order solution maps the valve’s switching property. A modification of the procedure allows for the asymptotic approximation of the system’s forced response to an external excitation. The approximate solutions are validated within a realistic parameter range by comparison with numerical solutions of the full system equations.
A strictly economic explanation of gender roles: the lasting legacy of the plough
Authors: Cigno Alessandro 
Published: February 2021

AbstractWe show that the descendants of ancient farmers may have an interest in marrying among themselves, and thus maintaining the gendered division of labour originally justified on comparative-advantage grounds by the advent of the plough, even after they emigrate to a modern industrial economy where individual productivity depends on education rather than physical characteristics. The result rests on the argument that, if efficiency requires the more productive spouse to specialize in raising income, and the less productive one in raising children, irrespective of gender, an efficient domestic equilibrium will be implemented by a costlessly enforceable pre-marital contract stipulating that the husband should do the former and the wife the latter. A contract may not be needed, however, if time spent with children gives direct utility, because an efficient equilibrium may then be characterized by little or no division of labour.
Augmented Reality in Orthopedic Surgery Is Emerging from Proof of Concept Towards Clinical Studies: a Literature Review Explaining the Technology and Current State of the Art
Authors: Casari Fabio A. , Navab Nassir , Hruby Laura A. , Kriechling Philipp , Nakamura Ricardo , Tori Romero , de Lourdes dos Santos Nunes Fátima , Queiroz Marcelo C. , Fürnstahl Philipp , Farshad Mazda 
Published: February 2021

Abstract
Purpose of Review
Augmented reality (AR) is becoming increasingly popular in modern-day medicine. Computer-driven tools are progressively integrated into clinical and surgical procedures. The purpose of this review was to provide a comprehensive overview of the current technology and its challenges based on recent literature mainly focusing on clinical, cadaver, and innovative sawbone studies in the field of orthopedic surgery. The most relevant literature was selected according to clinical and innovational relevance and is summarized.

Recent Findings
Augmented reality applications in orthopedic surgery are increasingly reported. In this review, we summarize basic principles of AR including data preparation, visualization, and registration/tracking and present recently published clinical applications in the area of spine, osteotomies, arthroplasty, trauma, and orthopedic oncology. Higher accuracy in surgical execution, reduction of radiation exposure, and decreased surgery time are major findings presented in the literature.

Summary
In light of the tremendous progress of technological developments in modern-day medicine and emerging numbers of research groups working on the implementation of AR in routine clinical procedures, we expect the AR technology soon to be implemented as standard devices in orthopedic surgery.