bluuebunny/crossref_metadata_2025_split huggingface dataset:
FOXE1 polymorphism rs965513 predisposes to thyroid cancer in a European cohort
Authors: Owens Patrick W , McVeigh Terri Patricia , Miller Nicola , Guerin Carole , Sebag Frederic , Quill Denis , Bell Marcia , Kerin Michael J , Lowery Aoife J 
Published: May 2021

Objective
FOXE1 is an intronless gene on chromosome 9 which plays a significant role in thyroid morphogenesis. Mutations in FOXE1 are associated with thyroid phenotypes including congenital hypothyroidism, thyroid dysgenesis and thyroid cancer. This study aims to investigate the frequency and impact of a SNP (rs965513, G>A) at 9q22.23 in a Western European cohort of patients with differentiated thyroid cancer(DTC), compared to controls.

Design
This is a candidate gene case control study.

Methods
277 patients with histologically confirmed DTC were recruited from tertiary referral centres in Ireland and France. 309 cancer-free controls were recruited from the community. DNA was extracted from buccal swabs or whole blood of control subjects and patients with DTC. Allelic and genotypic frequencies among patients were compared with controls, to assess the risk for disease conferred by homozygous and heterozygous carriers compared to WT genotypes. Genotyping was performed using Taqman-based PCR.

Results
277 patients with confirmed DTC and 309 non-cancer controls were genotyped for the variant (rs965513). The frequency of the minor allele among cases was 0.45 compared to 0.34 among controls. The genotypic odds ratio for heterozygotes was 1.66 (CI 1.16–2.39, P =0.00555), increasing to 2.93 (CI 1.70–5.05, P =0.00007) for rare homozygotes. All subjects were in Hardy-Weinberg equilibrium (±χ2, P =0.09, P =0.07 respectively).

Conclusions
This FOXE1 polymorphism is a low penetrance variant associated with DTC susceptibility in this cohort. The minor allele was identified among patients with thyroid cancer significantly more frequently than controls. An allele dosage effect was observed, with rare homozygous genotypes conferring greater risk than heterozygotes.
Incidence of COVID-19 and Risk of Diabetic Ketoacidosis in New-Onset Type 1 Diabetes
Authors: Kamrath Clemens , Rosenbauer Joachim , Eckert Alexander J. , Pappa Angeliki , Reschke Felix , Rohrer Tilman R. , Mönkemöller Kirsten , Wurm Michael , Hake Kathrin , Raile Klemens , Holl Reinhard W. 
Published: May 2021

OBJECTIVES
With this study, our aim was to quantify the relative risk (RR) of diabetic ketoacidosis at diagnosis of type 1 diabetes during the year 2020 and to assess whether it was associated with the regional incidence of coronavirus disease 2019 (COVID-19) cases and deaths.

METHODS
Multicenter cohort study based on data from the German Diabetes Prospective Follow-up Registry. The monthly RR for ketoacidosis in 2020 was estimated from observed and expected rates in 3238 children with new-onset type 1 diabetes. Expected rates were derived from data from 2000 to 2019 by using a multivariable logistic trend regression model. The association between the regional incidence of COVID-19 and the rate of ketoacidosis was investigated by applying a log-binomial mixed-effects model to weekly data with Germany divided into 5 regions.

RESULTS
The observed versus expected frequency of diabetic ketoacidosis was significantly higher from April to September and in December (mean adjusted RRs, 1.48–1.96). During the first half of 2020, each increase in the regional weekly incidence of COVID-19 by 50 cases or 1 death per 100 000 population was associated with an increase in the RR of diabetic ketoacidosis of 1.40 (95% confidence interval, 1.10–1.77; P = .006) and 1.23 (1.14–1.32; P &lt; .001), respectively. This association was no longer evident during the second half of 2020.

CONCLUSIONS
These findings suggest that the local severity of the pandemic rather than health policy measures appear to be the main reason for the increase in diabetic ketoacidosis and thus the delayed use of health care during the pandemic.
O Modelo da Sala de Aula Invertida: Uma estratégia ativa para o ensino presencial e remoto
Authors: Tomaschewski Bueno Maria Bethânia , Da Rosa Rodrigues Emerson , Giusti Moreira Maria Isabel 
Published: May 2021

O modelo da Sala de Aula Invertida abarca como uma possibilidade no processo de ensino e de aprendizagem e com o surgimento da Pandemia da Covid-19 se intensificou as reflexões por outras propostas no contexto educacional. Com isso, esta pesquisa tem como objetivo refletir perante a percepção de docentes frente ao modelo da Sala de Aula Invertida como uma estratégia ativa no processo de ensino e de aprendizagem. A pesquisa possui abordagem qualiquantitativa e foi delineada aos 132 docentes do Campus Pelotas - Visconde da Graça do Instituto Federal Sul-rio-grandense com aplicação de um questionário pelo recurso do Google Forms com perguntas abertas e fechadas no período de dezembro de 2020 a janeiro de 2021. Os resultados evidenciaram que esses docentes estão dispostos a implementar e a conhecer outras propostas no contexto educacional, possuem o entendimento frente ao Ensino Híbrido e especificamente ao modelo delineado. Apesar do retorno exíguo de participantes, considera-se esta pesquisa uma provocação a futuros estudos, pois se trata de uma temática contemporânea, relevante e de discussão crescente.
Przyjemność i dobro w dialogu Protagoras Platona
Authors: Gródek Wojciech Kleofas 
Published: May 2021

Artykuł jest próbą wyjaśnienia, dlaczego w dialogu Protagoras Platon ustami Sokratesa uznaje przyjemność (hedone) za dobro (agathon). Interpretatorzy nie są zgodni co do oceny samej tezy i jej uzasadnienia przez Sokratesa. Wydaje się być ona sprzeczna z poglądami Platona w innych dialogach. Część interpretatorów twierdzi, że jest to prawdziwe spojrzenie samego Sokratesa lub wczesnego Platona z okresu, kiedy pisał dialog. Inni twierdzą, że teza ta jest przesłanką służącą do udowodnienia twierdzenia, iż cnota jest wiedzą. Pojawił się również pogląd, że jedynie pobieżne czytanie tekstu może skłaniać czytelnika do uznania, iż Sokrates poważnie traktuje tezę o związku przyjemności z dobrem. Jeżeli jednak nie traktuje tej tezy poważnie, to dlaczego próbuje przekonać do niej swoich rozmówców? Mając na uwadze te wątpliwości, podjęto analizę tekstu dialogu w celu rozpoznania, czy pojawia się w nim wzmianka o cechach właściwych dobru, które decydują o przyjemności. Ważnym punktem w uzasadnianiu związku przyjemności z dobrem jest wskazanie przez Sokratesa, czym należy się kierować w postępowaniu, aby odczuwać przyjemność w całym życiu i uniknąć złudzeń, dzięki którym pojawia się mniemanie, że przyjemność jest zła. W wyniku przeprowadzonych analiz można postawić wniosek, że decydującą rolę w uzyskaniu stanu gwarantującego przyjemność w ­całym życiu odgrywa panowanie nad sobą samym.
Zmierzch mistrzów i brzask bożyszcz. Ojca Bocheńskiego teoria autorytetu
Authors: Okołowski Paweł 
Published: May 2021

Zjawisko autorytetu należy do zjawisk najważniejszych w życiu społecznym, a jego pojęcie do najtrudniejszych w teoretycznym ujęciu. Na tle obszernej literatury przedmiotu wyróżnia się niezrównana rozprawa ojca Jana Marii Bocheńskiego Co to jest autorytet? z roku 1974. Autor daje w niej 88 tez z metafizyki człowieka, charakteryzujących autorytet.Teza główna głosi, że „każdy autorytet jest autorytetem epistemicznym albo deontycznym”. Teza ta jest wątpliwa, lecz wywody Bocheńskiego niezwykle jasne – stwarzające w ogóle możliwość budowania teorii autorytetu. Autor niniejszego artykułu twierdzi, że zasadniczy podział autorytetów dzieli je na osobowe i instytucjonalne, te pierwsze zaś rozpadają się na bratnie i sekciarskie. Bratni autorytet osobowy to „miłość wzajemna do osoby, między nierównymi” – kategoria podstawowa, wyróżniona przez Arystotelesa. Jest on zawsze epistemiczno-deontyczny. Jako wzorzec zachowań silnie jest obecny także w Chinach czy Indiach. Bocheński go nie docenił.We współczesnym świecie Zachodu ma miejsce „upadek autorytetów” czy, inaczej mówiąc, „dominują autorytety fałszywe”. Oznacza to, że brakuje autorytetów bratnich, czyli mistrzów, a plenią się autorytety sekciarskie oraz związki typu idol-fan (kwitną „bożyszcza”). Upadek autorytetu jest skutkiem rozwoju technologii, która zasadniczo odmieniła warunki ludzkiego życia, utrudniając rozpoznawanie bratnich dusz.
Problem ideałów w twórczości i życiu Fiodora Dostojewskiego. Polemika z uwagami Lwa Szestowa
Authors: Putała Nina 
Published: May 2021

Lew Szestow w swoim studium nad twórczością i życiem Fiodora Dostojewskiego ukazuje pisarza jako myśliciela, który wraz z doświadczeniem życiowym wyzbywa się naiwnego odniesienia do ideałów i stopniowo odkrywa istotę dramatu ludzkiej egzystencji. Szestow – krytyk idealizmu i tradycji opartej na rozumie – pokazuje proces porzucania przez Dostojewskiego ideałów jako akt filozoficznej odwagi i wyjście z ograniczeń racjonalnego dyskursu. Przy tym Szestow pomija pozytywną, poznawczą funkcję odniesienia do ideałów, którą – zdaniem autorki – Dostojewski, wbrew przypisywanym mu przez Szestowa poglądom, zauważa.
Early Copper Age Graves from Polgár-Nagy-Kasziba
Authors: Solnay Eszter 
Published: May 2021

Four Early Copper Age graves were excavated at Polgár-Nagy-Kasziba; two young children, and two adults – the latter including an elderly man and a woman. They all belong to the so-called Tiszapolgár culture. Thanks to numerous examinations – meaning anthropology, pathology or AMS dating –, much information were revealed about the four individuals, but they were never completely published. This paper analyses in details the whole grave cluster compared to the other graves from the Tiszapolgár culture, especially at the Polgár region. As a result, the personal biographies of the four individuals were created. However, it seems that all the four deceased were connected to high prestige in some way because of their age, gender, kinship or personal achievements.
Archaeological investigations on the Süttő plateau in 2018
Authors: Czajlik Zoltán , Novinszki-Groma Katalin , Rupnik László , Bödőcs András , Fejér Eszter , Jáky András , Puszta Sándor , Sörös Zsófia , Vass Bíborka , Czifra Szabolcs 
Published: May 2021

The Early Iron Age site complex of Süttő is located on a loess plateau on the right bank of the Danube. After a long history of research of the Early Iron Age fortified settlement, tumulus groups and flat cemetery, between 2013–2017, some pioneer investigations were carried out using non-invasive methods. In 2018, members of the Institute of Archaeological Sciences of the Eötvös Loránd University and the Archaeological Heritage Protection Directorate of the Hungarian National Museum conducted an interdisciplinary research project (archaeological excavation, geophysical measurements, metal detecting survey, systematic field walking, geological drilling) on the plateau in the framework of the Interreg DTP Iron Age Danube project. As a result of intensive research, it became clear that aside from the Early Iron Age necropolis, the eastern part of the plateau was used as a burial site in the Early Bronze Age, as a settlement in the Late Bronze Age, and we must consider the existence of a Late Iron Age settlement in this area as well.
The Impact of Parental Involvement and Expectations on Elementary School Students' Academic Achievement
Authors: LİNDBERG E.nihal , GÜVEN Pınar 
Published: May 2021

This study is a correlational research that aims to define the relationship between parental involvement, parental expectations and elementary school students’ academic success. The research was conducted in …… province and in defining the sample of the study, it was aimed to ensure the diversity of socioeconomic level and sociocultural status. Totally, 420 parents have voluntarily participated in the research after the purpose of the study explained to them. The data was gathered with the Scale for School and Family Involvement in Elementary Schools, subscale of parents developed by Sheldon and Epstein’s (2007) which has been adapted into Turkish by Oğuz (2012). While there was only one dependent variable of the study (academic success), there are six independent variables (parents’ educational status, household income, parents’ gender, child’s gender, parental involvement, parental expectation).
Within the research, independent samples t-test and Chi-square independence test were used. Moreover, logistic regression analysis was performed in order to define the power of predictability of the variables. Results showed that, there are not significantly statistical relations between academic success and parents’ gender, children’s gender, parental involvement at school. On the other hand, it has been concluded that parents’ educational status, household income, parental expectation and parental involvement at home are significantly correlated with children’s academic success. It was seen that the most important predictor of a child’s academic success is parental expectations. Based on the results, recommendations were developed for parents, schools and researchers.
Non-drug technologies in the prevention of arterial hypertension in civil aviation dispatchers
Authors: Korolev Denis V. , Yamerskov Vladimir V. 
Published: May 2021

Purpose. In recent decades, there has been an increased interest in the study of the prevention of cardiovascular diseases in civil aviation dispatchers, for whom professional stress is one of the leading risk factors in the formation of arterial hypertension in the workplace.
Material and methods. The article presents the survey data of 120 civil aviation dispatchers, who, in order to reduce the prevention of the development of arterial hypertension, underwent a complex of combined color-light-and psycho-correctional music therapy.
Conclusion. As a result of the study, it was proved that the combined color-light therapy technology and psycho-correctional music therapy have a pronounced vasocorrecting effect, which is confirmed by a decrease in systolic and diastolic pressure and heart rate to the level of healthy individuals in the studied contingent of air traffic controllers.
The New England earthquake of January 7, 1925
Authors: Porter William W. 
Published: May 2021

Summary
An earthquake occurred on the morning of January 7, 1925. It was felt in eastern Massachusetts, and adjacent parts of Rhode Island, New Hampshire, and Maine. Distance from Harvard seismograph forty-five kilometers. Epicentral area thought to be near Cape Ann. Not felt at sea. Closely related to an earthquake area in northeast Massachusetts. Radius of periphery of disturbed area from epicentral area,—maximum seventy-five miles, minimum fifty miles. Maximum intensity barely V, Rossi-Forel Scale.
Epicentral time and surface structure determined for the Tango earthquake, Japan, March 7, 1927
Authors: Hodgson Ernest A. 
Published: May 2021

XIV. SummaryIt is concluded that: The major energy of the Tango earthquake, causing the elastic waves which registered on seismographs all the world over, was released at 9h 27m 44s, G.M.T., March 7, 1927, from a single focus about 12 kilometers below the epicenter, which lay some 7 kilometers southwest of the Gomura fault and about 12.5 kilometers northwest of the Yamada fault, that is to say at 35° 36′.4 N., 134° 58′.2 E., in a surface stratum only some 16 kilometers thick, in which the velocity of the longitudinal wave has the unusually high average value of 6.3 kilometers per second, the velocity for the same wave below the discontinuity being 7.75 kilometers per second and about the inner edge of the mantle at its contact with the core 12.4 kilometers per second. The P- and S-curves of the previous paper are to be subjected to a constant correction of — 11 seconds in the light of the foregoing results, which indicate an epicentral time of 9h 27m 46s instead of the tentatively assumed 9h 27m 35s. Arguments are advanced for believing the corrected P-curve for the Tango earthquake to be reasonably well established except for a range of several degrees on each side of an epicentral distance of 20°.
Remarks on the diurnal variation of earthquake occurrence with reference to the Helena, Montana, swarm*
Authors: Landsberg H. 
Published: May 2021

Summary
From the observations of the Helena, Montana, swarm earthquakes it is deduced that a maximum of earthquakes of the swarm type occurs in the early morning hours of local time and that there exists a distribution of about 42 per cent of the shocks in the daytime, and 58 per cent in the nighttime. This is confirmed by material from earthquakes from widely different seismic periods and regions.
Materials for the study of deep-focus earthquakes*
Authors: Gutenberg B. , Richter C. F. 
Published: May 2021

Summary (Abstract)
Travel times of normal earthquakes are made the basis for calculated travel times for shocks at depths down to 800 km. These are presented in tabular form, together with certain auxiliary data. Theoretical discussion is given for the critical distances at which pP and PP, sP and SP, etc., coincide, and below which these phases should not occur. These distances are not focal points (caustics). Methods are given for determining epicenter, depth, and origin time, and are applied to a selected group of shocks. The results of different methods agree very well with one another and with the calculated travel-time data. A preliminary report is given on certain characteristics of the shocks studied. The mechanism of deep-focus earthquakes is discussed briefly, and it is concluded that normal and deep-focus earthquakes are probably brought about by the same forces.
The earthquake of November 14, 1937*
Authors: Lynch Joseph 
Published: May 2021

Abstract
In this preliminary paper on the earthquake of November 14, 1937, the S and SKS curves of the quake (h = 250 km.) are compared with those of Gutenberg and Brunner for the same depth. The S curve of both Gutenberg and Brunner is confirmed from 50° to 100° within a few seconds. The SKS curve of Gutenberg is confirmed from 85° to 105° within a few seconds, while that of Brunner over the same range would seem to have an average error of 13 seconds. From 105° to 115° Brunner's curve is in fair agreement with that of the author, while Gutenberg's diverges rapidly after 105° to a difference of 14 seconds at 115°. The SKKS-SKS interval decreases with increasing distance between 103° and 107°.
Ground vibrations near dynamite blasts*
Authors: Leet L. Don 
Published: May 2021

Summary
In general, then, the concentrated energy at the source is actually divided among the principal wave types, which are there added together. Within very short distances, however, these wave types begin to separate because of their different velocities. There are thus two factors working to reduce the maximum shaking to which the ground is subjected. One is the natural decay of each wave with distance, as internal friction exhausts its original energy. The other, which is usually the dominating effect at short distances, is this stringing out of the wave types, each carrying its portion of the initial energy, until there is no longer any concentration where two or more types join forces to produce additive amplitudes.
Seismic activity in the Imperial Valley, California*
Authors: Wood Harry O. 
Published: May 2021

Abstract
Following a brief résumé of the historical record of the occupation of the Imperial Valley by people, and of the earthquakes reported felt, there are given estimates of the number of such shocks which are judged to pertain to the immediate region for the intervals (a) 1769 to June 10, 1902, and (b) June 10, 1902, through May, 1940; also the number of such shocks instrumentally recorded but not reported felt during the interval October, 1926, through May, 1940, with a few brief interruptions. These lists make it clear that the Valley region has long been markedly active, but not so greatly so as some similar districts elsewhere. Dates, and brief descriptions, are given for a number of the more important shocks, and the effect of the May 18, 1940, shock is appraised briefly.
Instrumental study of the New Hampshire earthquakes of December, 1940*
Authors: Leet L. Don , Linehan D. 
Published: May 2021

ABSTRACT
Astudy of original records and bulletin readings for two strong earthquakes in the Ossipee Mountains district of southeastern New Hampshire in December, 1940, gave for both
φ = 43 ° 50 ′ N λ = 71 ° 1 7 ′ W
S started from a depth of approximately 35 km., and P at the same time from a depth of 15 km. The second shock was multiple. Times at the focus were:
1940 December 20 d 07 h 27 m 26 s 24 d 13 h 43 m 45 s 47 s 57 s
The velocities observed, in km/sec., were: P1+26.44S1+23.82P37.30S34.02Pn8.44Sn4.43
Mechanism at the focus probably differed from that of earthquakes which involve surface faulting, but is not discussed in detail in this paper. First motion from the second earthquake was reversed from that of the first at near-by stations. No foreshocks preceded the first earthquake; there was a small one just before the second; and there were only ten after-shocks, the last one occurring on February 12, 1941.
The Richter magnitude was at least 6 for the first and slightly greater for the second main shock. From this the energy can be computed as 1020 ergs or 7.4 × 1012 foot-pounds. This ranks both shocks as potentially destructive. They were felt to a distance of 350 miles, which means an area of potential perceptibility of the order of 385,000 square miles.
Microseisms at Berkeley and Surf on near-by coasts*
Authors: Byerly Perry 
Published: May 2021

Summary and Conclusions
The amplitudes of microseisms recorded at Berkeley correlate over six-months and yearly periods with surf strength on near-by beaches quite as well as the observations of surf strength at adjacent stations correlate with each other, all the correlation ratios being between 0.53 and 0.58. During a winter month the correlation between microseisms and surf rose to 0.81. A consideration of energies leads to the conclusion that the energy of average large microseisms at Berkeley can be explained as due to surf on near-by beaches if about 10−7 of the potential energy of probable-sized deep-water waves is eventually transformed into elastic Rayleigh waves at the near-by beaches.
Not all microseisms at Berkeley are caused by near-by surf, but many may very well be. It is possible to pick periods when one is large and the other is not, and vice versa. It is also possible to find times when very heavy seas and very large microseisms begin together in a most conspicuous fashion.
Apparent origin time of S̄ *
Authors: Gutenberg B. , Richter C. F. 
Published: May 2021

abstractRepresentative travel times for 50 shocks in southern California indicate that transverse waves appear to leave the focus about half a second earlier, on the average, than longitudinal waves. If fault rupture is propagated with a speed greater than that of transverse waves, the originating of such waves along a moderately extended fault segment will completely explain the observations. An exact theory is given on the simplest assumptions.