bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualised music for people living with dementia and the experiences and perceptions of residential aged care staff: A qualitative study
Authors: Gaviola Minah Amor , Higgins Isabel , Dilworth Sophie , Holliday Elizabeth , Inder Kerry J. 
Published: August 2021

AbstractObjectiveTo explore the experiences and perceptions of staff regarding the use of individualised music for people with dementia living in residential aged care.MethodsA qualitative descriptive methodology was used. Methods included a focus group and face‐to‐face interviews, open‐ended responses to a pre‐post survey and relevant clinical notes about older participants’ responses. Qualitative content analysis was used to analyse data.ResultsThere were four themes: (1) transcendental reminiscing, the calm, the joy and the elation; (2) optimism, excitement and the snowball effect; (3) pitching in for older person, it is not rocket science and the hurdles; and (4) music beyond the intervention.ConclusionsOverall, the individualised music was a generally positive experience. While some older participants reported discomfort with the use of headphones, staff concerns related to care and accessibility of music equipment.
Incidence of self‐induced abortion with misoprostol, admitted to a provincial hospital in Papua New Guinea: A prospective observational study
Authors: Bolnga John W , Lufele Elvin , Teno Mitilam , Agua Vero , Ao Paula , DL Mola Glen , Pomat William , Laman Moses 
Published: August 2021

BackgroundMisoprostol is a life‐savingmedication in obstetric practice but the prevalence of misoprostol‐related self‐induced abortion is increasing in many communities.AimsTo investigate the hospital incidence, clinical management, and legal framework of self‐induced abortions with misoprostol.Materials and MethodsThis was a prospective observational study conducted over 18 months. All patients <20 weeks pregnant who were admitted with a diagnosis of misoprostol‐induced abortion were included in the study.ResultsOf 186 women with abortion‐related admissions during the study period, 51 (27.4%) women reported using misoprostol to induce abortion. The majority were young (27.8 ± 5.5) married women (32/51: 62.7%), particularly educated (27/51: 52.9%) employed women (27/51: 52.9%), who were not on any contraception (46/51: 90.1%). Most abortions were induced in the first trimester (39/51: 76.5%) and patients were admitted because of prolonged bleeding (23/51: 45.1%). A significant proportion of participants who did not receive the correct dose of misoprostol developed sepsis compared to those who received a correct dose (6/18 (33.3%) vs 1/30 (3.3%); P = 0.008).ConclusionThe use of misoprostol as an abortifacient is increasing in Papua New Guinea, particularly among educated and employed women. A review of the laws to meet the demand for abortion services and to limit complications of unsafe abortion practices is required.
The Humber is a Haunting: Settler Deathscapes, Indigenous Spectres, and the Memorialisation of a Canadian Heritage River
Authors: Fortier Craig 
Published: August 2021

AbstractThis paper argues that state‐sponsored memorialisation is a critical enterprise in creating and maintaining a national cultural identity that softens or erases the ongoing process of death‐making and dispossession wrought by settlers on the land and Indigenous peoples. Drawing on the work of Toronto‐based Cree scholar Karyn Recollet, I further argue that this death‐making is not a given. Indigenous peoples assert their presence and relationships to the Humber River and its adjacent lifeforces alongside and in opposition to official memorialising projects. The 20thanniversary of the Humber River’s designation as a Canada Heritage River in 2019, the first in the era of the Truth and Reconciliation Commission of Canada’s Calls to Action, begs the question as to the role memorial and commemoration ceremonies play in the coalescence of a particular settler colonial story/myth that stabilises geographies as “memorial spaces” while simultaneously narrating Indigenous peoples through erasure, assimilation, and as historical ghosts.
Clinical implementation of pre‐biopsy magnetic resonance imaging pathways for the diagnosis of prostate cancer
Authors: Israël Bas , Immerzeel Jos , van der Leest Marloes , Hannink Gerjon , Zámecnik Patrik , Bomers Joyce , Schoots Ivo G. , van Basten Jean‐Paul , Debruyne Frans , van Oort Inge , Sedelaar Michiel , Barentsz Jelle 
Published: August 2021

ObjectiveTo assess the outcomes of pre‐biopsy magnetic resonance imaging (MRI) pathways, as a tool in biopsy‐naïve men with suspicion of prostate cancer, in routine clinical practice. Secondary outcomes included a comparison of transrectal MRI‐directed biopsy (TR‐MRDB) and transperineal (TP)‐MRDB in men with suspicious MRI.Patients and MethodsWe retrospectively assessed a two‐centre cohort of consecutive biopsy‐naïve men with suspicion of prostate cancer who underwent a Prostate Imaging‐Reporting and Data System version 2 (PI‐RADS v2) compliant pre‐biopsy MRI in a single, high‐volume centre between 2015 and 2019 (Centre 1). Men with suspicious MRI scans underwent TR‐MRDB in Centre 1 and TP‐MRDB with additional random biopsies (RB) in Centre 2. The MRI and histopathology were assessed in the same institution (Centre 1). Outcomes included: (i) overall detection rates of Grade Group (GG) 1, GG ≥2, and GG ≥3 cancer in men with suspicious MRI; (ii) Biopsy‐avoidance due to non‐suspicious MRI; and (iii) Cancer detection rates and biopsy‐related complications between TR‐ and TP‐MRDB. To reduce confounding bias for MRDB comparisons, inverse probability weighting (IPW) was performed for age, digital rectal examination, prostate‐specific antigen (PSA), prostate volume, PSA density, and PI‐RADS category.ResultsOf the 2597 men included, the overall GG 1, GG ≥2, and GG ≥3 prevalence was 8% (210/2597), 27% (697/2597), and 15% (396/2597), respectively. Biopsy was avoided in 57% (1488/2597) of men. After IPW, the GG 1, GG ≥2 and GG ≥3 detection rates after TR‐ and TP‐MRDB were comparable at 24%, 57%, and 32%; and 18%, 64%, and 38%, respectively; with mean differences of −5.7% (95% confidence interval [CI] −13% to 1.4%), 6.1% (95% CI −2.1% to 14%), and 5.7% (95% CI −1.7% to 13%). Complications were similar in TR‐MRDB (0.50%) and TP‐MRDB with RB (0.62%; mean difference 0.11%, 95% CI −0.87% to 1.1%).ConclusionThis high‐volume, two‐centre study shows pre‐biopsy MRI as a decision tool is implementable in daily clinical practice. Compared to recent trials, a substantially higher biopsy avoidance rate was achieved without compromising GG ≥2/GG ≥3 detection and coinciding with lower over detection rates of GG 1 cancer. Prostate cancer detection and complication rates were comparable for TR‐ and TP‐MRDB.
Clinical efficacy of anodized dental implants for implant‐supported prostheses after different loading protocols: A systematic review and meta‐analysis
Authors: Nagay Bruna Egumi , Dini Caroline , Borges Guilherme Almeida , Mesquita Marcelo Ferraz , Cavalcanti Yuri Wanderley , Magno Marcela Baraúna , Maia Lucianne Cople , Barão Valentim Adelino Ricardo 
Published: August 2021

AbstractObjectivesTo summarize the clinical performance of anodized implants connected to different prostheses design after immediate/early (IL) or conventional loading (CL) protocols.Materials and MethodsSeven databases were surveyed for randomized (RCTs) and non‐randomized controlled clinical trials (CCTs). Studies comparing ILvs. CL protocol of anodized implants supporting single crown, fixed partial denture (FPD), full‐arch fixed dental prosthesis (FDP), or overdenture were included. Risk‐of‐bias was evaluated using Cochrane Collaboration tools. Meta‐analyses for different follow‐up were analyzed, followed by heterogeneity source assessment and GRADE approach. The outcomes included implant survival rate, marginal bone loss (MBL), implant stability quotient (ISQ), probing depth (PD), plaque index (PI), and peri‐implantitis prevalence.ResultsFrom 24 eligible studies, 22 were included for quantitative evaluation. Most RCTs (58%,n = 11) and all the 5 CCTs had high and serious risk‐of‐bias, respectively. Overall, pooling all prosthesis design, no difference between ILvs. CL protocols was observed for all outcomes (p > .05). However, according to prosthesis type subgroups, CL reduced MBL for full‐arch FDP (p < .05). In a point‐in‐time assessment, with overdenture, although IL presented higher PI (12 months), it showed lower MBL (≥24 months), higher ISQ (3 months), and lower PD (6 and 12 months) (p < .05). Conversely, PD was higher for IL in single crown (3 and 6 months) (p < .05). Regarding MBL, IL demonstrated higher mean difference for full‐arch FDP (36 months) and FPD (12 and 36 months) (p < .05).ConclusionWithin the limitations of this study, overall, there is no significant difference in the outcomes between IL and CL loading protocols.
The use of rhBMP2 for augmentation of established horizontal/vertical defects may require additional use of rhVEGF to achieve significant bone regeneration: An in vivo experimental study
Authors: Kauffmann Philipp , Raschke David , Tröltzsch Markus , Santander Petra , Brockmeyer Phillip , Schliephake Henning 
Published: August 2021

AbstractAimTo test the hypothesis that the use of rhBMP2 in established defects requires additional growth factors such as rhVEGF to accomplish effective bone repair.Materials and MethodsHorizontal/vertical defects of 2 cm length and 1 cm height were created bilaterally in the alveolar crest of the maxillae of 18 minipigs together with the extraction of all premolar teeth and one molar tooth on both sides. After 3 months of healing, defects were augmented with 0.5 g particulate PDLLA/CaCO3 composite loaded with 400 µg rhBMP2/50 µg rhVEGF165 on one side and 800 µg rhBMP2 on the other in 12 test animals, whereas defects in six control animals were sham operated and left unfilled on one side and augmented with blank carriers on the other. After 4 and 13 weeks, the animals were evaluated each for area of new bone formation (mm²) and bone density (area %).ResultsAugmentations with carriers loaded with 800 g µrhBMP2 failed to induce significantly more bone than in the augmentations with unloaded carrier after 4 and 13 weeks (p = .1000,p = .381). Augmentations with carriers loaded with 400 µg rhBMP2 and 50 µg erhVEGF165 resulted in significantly increased bone formation after 13 weeks (p = .024) compared to blank carriers. Soft tissue in augmentations with combined rhBMP2/rhVEGF165 loading exhibited numerous microvessels compared to soft tissue in augmentations with rhBMP2.ConclusionsIt is concluded that effective bone regeneration in augmentations of established alveolar ridge defects may require the application of rhVEGF additionally to rhBMP2.
Response of balsam poplar to inoculation withMarssonina balsamiferaefrom Minnesota, USA
Authors: Stanosz Glen R. , Smith Denise R. , Ramsfield Tod D. , McMahon Bernard G. , Berguson William E. 
Published: August 2021

AbstractLeaf spots of poplar (Populus) species and hybrids in North America commonly are caused by threeDrepanopezizaspecies (previously referred to by their asexual morph names in genusMarssonina). A fourth species,Marssonina balsamiferae, is known only from herbarium specimens and was described from balsam poplar (Populus balsamifera) leaves collected in 1966 in Manitoba, Canada. Balsam poplar leaves collected in 2014 in Minnesota, USA bore spots with acervuli and conidia consistent with those ofM. balsamiferae, and isolates were obtained from these leaves. Conidial morphology and analysis of nuclear ribosomal ITS sequences distinguished the Minnesota strains from the very common leaf spot pathogen of poplars in the northcentral region of the USA,Drepanopeziza brunnea. Inoculation of rooted balsam poplar cuttings with conidia ofM. balsamiferaestrains from Minnesota resulted in necrotic leaf spots. Acervuli bearing conidia consistent with those ofM. balsamiferaewere observed on symptomatic leaves, and the fungus was reisolated from infected tissues. Contemporary recognition of existence and pathogenicity ofM. balsamiferae, including presence in the USA, should prompt further investigation of its geographic distribution and relationships with hosts and related fungal species.
Understanding long‐term changes in patient identity 15–20 years after surgery for temporal lobe epilepsy
Authors: Coleman Honor , McIntosh Anne , Rayner Genevieve , Wilson Sarah J. 
Published: August 2021

AbstractObjectiveFollowing epilepsy surgery, patients can experience complex psychosocial changes. We recently described a longer term adjustment and reframing (“meaning‐making”) process 15–20 years following surgery for temporal lobe epilepsy, which could involve an ongoing sense of being a “different” person for some patients. Here, we quantitatively examine identity at long‐term follow‐up and how this relates to meaning‐making and postoperative seizure outcome.MethodsEighty‐seven participants were included: 39 who underwent anterior temporal lobectomy (ATL) 15–20 years ago (59% female; median age = 49.2 years, interquartile range [IQR] = 10; median follow‐up = 18.4 years, IQR = 4.4) and 48 surgically naïve focal epilepsy patients (56% female; median age = 34.5 years, IQR = 19). We captured approach to meaning‐making by coding for key narrative features identified in our previous qualitative work. Nonparametric tests and correspondence analysis were then used to explore relationships between a quantitative measure of identity and meaning‐making, as well as seizure outcome, mood, and health‐related quality of life (HRQOL).ResultsPatients 15–20 years post‐ATL demonstrated a shift toward increasing identity commitment and exploration compared to the surgically naïve cohort, with this shift significantly linked to seizure outcome. Examining the relationship between identity and meaning‐making also revealed three groups: (1) those who embraced self‐change (29%), (2) those who continued to struggle with this process (60.5%), and (3) those who showed minimal engagement (10.5%). Those who "embraced change" were significantly younger at regular seizure onset and demonstrated a trend toward higher HRQOL.SignificanceFindings suggest that ATL patients show a more developed identity profile compared to surgically naïve controls; however, the majority still struggled with postoperative identity change at long‐term follow‐up. Approximately one third of patients demonstrated positive psychological growth following surgery, reflected in the ability to embrace change. Findings highlight the importance of understanding the impact of surgery on patient identity to maximize the psychosocial benefits.
Deliberate self‐harm among adolescents: A structural equation modelling analysis
Authors: Singtakaew Arunothai , Chaimongkol Nujjaree 
Published: August 2021

AbstractDeliberate self‐harm is an intentional behaviour involving direct destruction of body tissues that causes non‐fatal physical trauma to the extent that bleeding or bruising occurs without conscious suicidal intent. Adolescents’ self‐harm is an important issue in mental health work due to its high prevalence in Thailand. This study aims to test a causal model of deliberate self‐harm and identify how sex, family relationship, school connectedness, stress, resilience, and self‐control influenced deliberate self‐harm behaviour in Thai adolescents. A model‐testing, cross‐sectional study was conducted to test a causal model of deliberate self‐harm in Thai adolescents. Multi‐stage random sampling was used to recruit 360 adolescents. Adolescents completed six self‐report instruments: the family relationship questionnaire, student‐school connectedness scale, resilience factors scale for Thai adolescents, self‐control questionnaire, Perceived Stress Scale‐10 (Thai version), and Deliberate Self‐Harm Inventory. Internal consistencies ranged from 0.81 to 0.89. Data were analysed by using descriptive statistics and structural equation modelling. The findings found sex, resilience, stress, and school connectedness had direct effects on deliberate self‐harm (β = −0.139, β = −0.266, β = 0.163, and β = −0.671, respectively). Resilience and stress also mediated the links between sex (female), family relationship, school connectedness, and deliberate self‐harm. The variables accounted for 65.2% of the variance in the prediction of deliberate self‐harm behaviour in Thai adolescents. These findings suggest the causal model of deliberate self‐harm fit the empirical data. Interventions to reduce stress and strengthen school connectedness, family relationship, and resilience among Thai adolescents should be implemented, particularly for boys, to prevent deliberate self‐harm.
Mesophyll conductance modulates photosynthetic rate in cotton crops exposed to heat stress under field conditions
Authors: Mercado Álvarez Kelly , Bertero H. Daniel , Paytas Marcelo J. , Ploschuk Edmundo L. 
Published: August 2021

AbstractCotton is often exposed to high temperatures during the reproductive stage, which can negatively affect its productivity. The objectives were to: i) test whether heat stress impacts during the reproductive stage on photosynthesis are due to instant temperature effects or to acclimation produced during the heat stress period, ii) evaluate the role of stomatal and mesophyll conductance on net photosynthetic rate and iii) identify possible interactions between heat stress and different source/sink ratios during the reproductive period. Two field experiments were carried out in 2016 (Exp. 1) and 2017 (Exp. 2). Two heating treatment periods were imposed as follows: pre‐flowering between 15 days before flower bud and flowering (H1) and post‐flowering between flowering and 15 days later (H2). Each treatment had a control group (C1 and C2, respectively). In Exp. 1, two genotypes with contrasting crop cycles were compared. In Exp. 2, 50% defoliated plants (D‐) were compared with intact plants (D+) under the same temperature treatments using one genotype. Average daily maximum temperature of heated treatments for both experiments was 37.9 ± 0.79ºC, 5.8ºC higher than the controls. Independently of the period, thermal stress had a negative impact on photosynthesis in both genotypes through an acclimation response, reducing it up to 35% compared with controls when heath‐stressed and control plants were measured at the same temperature. Instant responses to temperature were not observed. This decrease was mainly determined by mesophyll conductance, and no recovery was observed 15 days after the end of treatments. Photosynthesis depletion was conditioned by the source/sink ratio, showing a complete recovery only in defoliated plants. It is concluded that thermal stress had a negative acclimation impact on photosynthesis, without responses to changes in instant temperature, and this acclimation is modulated mainly by mesophyll conductance.
Doing Research‐Creation in School: Keeping an Eye on the Ball
Authors: Pahl Kate , Pool Steve 
Published: August 2021

AbstractThis article explores the potential of the idea of ‘research‐creation’ when working with children making films in the context of a project that explored children’s experience of school. The proposition of the article is that rather than see children’s work as something to be discussed or extracted from, if it is seen as ‘the work’ it is differently situated. In the article, an artist and an ethnographer explore the potential of artistic methodologies in working collaboratively with children. The article describes this process and engages with an interdisciplinary lens to explore the nature of this kind of work. The results of the art‐making activities included a series of short films made by children on their experience of feeling odd in school. Within these films, ideas surfaced such as ghosts or day‐dreaming. In the conclusion the implications for artistic research with children are explored.
Fluid shear stress regulates osteoblast proliferation and apoptosis via the lncRNA TUG1/miR‐34a/FGFR1 axis
Authors: Wang Xingwen , He Jinwen , Wang Hong , Zhao Dacheng , Geng Bin , Wang Shenghong , An Jiangdong , Wang Cuifang , Han Hua , Xia Yayi 
Published: August 2021

AbstractLncRNAs and microRNAs play critical roles in osteoblast differentiation and bone formation. However, their exact roles in osteoblasts under fluid shear stress (FSS) and the possible mechanisms remain unclear. The aim of this study was to explore whether and how miR‐34a regulates osteoblast proliferation and apoptosis under FSS. In this study, FSS down‐regulated miR‐34a levels of MC3T3‐E1 cells. MiR‐34a up‐regulation attenuated FSS‐induced promotion of proliferation and suppression of apoptosis. Luciferase reporter assay revealed that miR‐34a directly targeted FGFR1. Moreover, miR‐34a regulated osteoblast proliferation and apoptosis via FGFR1. Further, we validated that lncRNA TUG1 acted as a competing endogenous RNA (ceRNA) to interact with miR‐34a and up‐regulate FGFR1 protein expression. Furthermore, lncRNA TUG1 could promote proliferation and inhibit apoptosis. Taken together, our study revealed the key role of the lncRNA TUG1/miR‐34a/FGFR1 axis in FSS‐regulated osteoblast proliferation and apoptosis and may provide potential therapeutic targets for osteoporosis.
Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta‐analysis
Authors: Gad Hoda , Petropoulos Ioannis N , Khan Adnan , Ponirakis Georgios , MacDonald Ross , Alam Uazman , Malik Rayaz A 
Published: August 2021

ABSTRACTIntroductionCorneal confocal microscopy (CCM) is a rapid non‐invasive ophthalmic imaging technique that identifies corneal nerve fiber damage. Small studies suggest that CCM could be used to assess patients with diabetic peripheral neuropathy (DPN).AimTo undertake a systematic review and meta‐analysis assessing the diagnostic utility of CCM for sub‐clinical DPN (DPN−) and established DPN (DPN+).Data sourcesDatabases (PubMed, Embase, Central, ProQuest) were searched for studies using CCM in patients with diabetes up to April 2020.Study selectionStudies were included if they reported on at least one CCM parameter in patients with diabetes.Data extractionCorneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), and inferior whorl length (IWL) were compared between patients with diabetes with and without DPN and controls. Meta‐analysis was undertaken using RevMan V.5.3.Data synthesisThirty‐eight studies including ~4,000 participants were included in this meta‐analysis. There were significant reductions in CNFD, CNBD, CNFL, and IWL in DPN− vs controls (P < 0.00001), DPN+ vs controls (P < 0.00001), and DPN+ vs DPN− (P < 0.00001).ConclusionThis systematic review and meta‐analysis shows that CCM detects small nerve fiber loss in subclinical and clinical DPN and concludes that CCM has good diagnostic utility in DPN.