bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic and prognostic value of serum soluble CD163 in cirrhotic patients with hepatitis C virus-related hepatocellular carcinoma before and after locoregional therapy
Authors: Sakr Marwa Ahmed , Mohamed Khaled Abdel Hamid , Hussein Ahmed Mohamed , Fouad Mohamed Hassan , Allam Ahmed Samir , Safwat Eslam 
Published: March 2021

Abstract
Background
Tumor-associated macrophages (TAMs), inflammatory cells in tumor microenvironment, are crucial for the tumor occurrence and progression which in turn increase the expression of soluble CD163 (sCD163). Nevertheless, not much has been established regarding sCD163 and its connection to HCC diagnosis and prognosis. This study was conducted to evaluate the diagnostic and prognostic role of sCD163 in patients with HCC on top of HCV-related liver cirrhosis. Forty adult patients with HCV-related liver cirrhosis and HCC (HCC group) were randomly selected and subjected to locoregional therapies, either transarterial chemoembolization (TACE) or radiofrequency ablation (RFA). Four patients were excluded because of portal vein invasion. Another group of 20 patients with liver cirrhosis only served as controls (LC group). Routine laboratory studies and abdominal ultrasound were done for all. Alpha-fetoprotein (AFP) and sCD163 were measured twice, at baseline and 1-month post-intervention, using a commercially available enzyme-linked immunosorbent assay kit.

Results
At baseline, sCD163 showed an insignificant higher value in HCC group (p > 0.05). The best cutoff value for sCD163 and AFP was 6.2 mg/L and 195 ng/mL, respectively. AFP had a larger area under the curve (0.88 vs. 0.767). An overall significant decline was seen in sCD163 after treatment (6.5±1.5 to 3.1±2.5 mg/L; p < 0.001), while AFP showed an insignificant decrease (p > 0.05). Also, sCD163 decreased significantly in the eradicated cases (6.1±1.4 mg/L before intervention vs. 2.3±1.4 mg/L after intervention, p < 0.01), while there was a significant increase in the recurrent cases (8.4±0.4 mg/L before intervention vs. 10.3±1.6 after intervention; p < 0.05). Moreover, sCD163 showed a significant difference in its pre-intervention and post-intervention values between recurrent and eradicated HCC cases (p < 0.01).

Conclusions
It is concluded that sCD163 has a minor role as a diagnostic marker for HCC, yet it could be used as a good prognostic marker in predicting the tumor response to locoregional therapies.
One Year of GH Treatment for Growth Failure in Children With Anorexia Nervosa: A Randomized Placebo-Controlled Trial
Authors: Léger Juliane , Fjellestad-Paulsen Anne , Bargiacchi Anne , Pages Justine , Chevenne Didier , Alison Marianne , Alberti Corinne , Guilmin-Crepon Sophie 
Published: March 2021

Abstract

Context
Children with anorexia nervosa (AN) are at risk of adult height deficit due to prolonged low height velocity (HV).

Objective
To investigate the effects of human growth hormone (GH) injections on HV in children with AN and severe growth impairment.

Design and participants
In this prospective, randomized, double-blind, single-center, proof-of-concept trial, children with AN and low HV (≤2 cm/year) for at least 18 months, and a bone age ≤12 years for girls and ≤14 years for boys, were randomized to receive daily subcutaneous injections of human GH (0.050 mg/kg/day) or placebo for 12 months.

Main outcome measures
Change in HV after 12 months.

Results
In total, 8 patients were assigned to the GH group and 6 to the placebo group. Patients had a median (25th-75th percentile) HV of 1.0 (0.5;1.5) cm/year. The effect of GH treatment increased strongly after 6 months, with a height gain after 12 months of 9.65 (8.0;11.6) cm for the GH group vs 3.85 (1.7;7.3) cm for the placebo group, with an absolute median (2.5th-97.5th percentile) difference between the groups of 5.8 (−1.85;9.68) cm after bootstrapping. The percentage of patients with a HV &gt; 5 cm/year during the study period was higher in the GH group than in the placebo group (100% vs 50%, P = 0.05). Adverse events occurred in similar numbers in the 2 groups, were mild or nonfatal, and did not lead to treatment being stopped.

Conclusion
GH administration to improve HV is a potentially valid option for increasing HV in children with AN and prolonged severe growth failure.
Ovarian Reserve Biomarkers and Menstrual Cycle Length in a Prospective Cohort Study
Authors: Harris Benjamin S , Steiner Anne Z , Jukic Anne Marie 
Published: March 2021

Abstract

Context
While age-related changes in menstrual cycle length are well known, it is unclear whether anti-Müllerian (AMH) or other ovarian reserve biomarkers have a direct association with cycle length.

Objective
To determine the association between biomarkers of ovarian reserve and menstrual cycle length.

Methods
Secondary analysis using data from time to conceive (TTC), a prospective time to pregnancy cohort study. The age-independent association between cycle length and biomarkers of ovarian reserve was analyzed using linear mixed and marginal models. Study participants were TTC-enrolled women aged 30-44 years with no history of infertility who were attempting to conceive for &lt;3 months were enrolled. Serum AMH, follicle-stimulating hormone, and inhibin B levels were measured on cycle day 2, 3, or 4. Participants recorded daily menstrual cycle data for ≤4 months. The primary outcome was menstrual cycle length; follicular and luteal phase lengths were secondary outcomes.

Results
Multivariable analysis included 1880 cycles from 632 women. Compared with AMH levels of 1.6 to 3.4 ng/mL, women with AMH &lt;1.6 ng/mL had cycles and follicular phases that were 0.98 (95% CI –1.46, –0.50) and 1.58 days shorter (95% CI –2.53, –0.63), respectively, while women with AMH &gt;8 ng/mL had cycles that were 2.15 days longer (95% CI 1.46, 2.83), follicular phases that were 2 days longer (95% CI 0.77, 3.24), and luteal phases that were 1.80 days longer (95% CI 0.71, 2.88).

Conclusion
Increasing AMH levels are associated with longer menstrual cycles due to both a lengthening of the follicular and the luteal phase independent of age.
Three-phase modeling and optimization of benzene alkylation in commercial catalytic reactors
Authors: Danesh Donya , Farsi Mohammad , Rahimpour Mohammad Reza 
Published: March 2021

Abstract
The main object of this research is heterogenous modeling of benzene alkylation in three phase reactors based on the mass and energy balance equations by coupling the kinetic and equilibrium models and optimization the process conditions to enhance production capacity. In the first step, the alkylation reactors are simulated considering a three-phase model including heat and mass transfer resistances in the solid catalyst, gas and liquid phases. To prove the accuracy of developed model and adopted assumptions, the simulation results are compared with the plant data. Based on the simulation results, the benzene conversion and ethylbenzene selectivity in the alkylation reactors are 15.03 and 94.60% at the conventional condition. In the second step, considering the temperature of inlet streams to the reactors as decision variables, an optimization problem is formulated to maximize the ethylbenzene production rate as the objective function. Based on the simulation results, applying optimal condition on the system improves the ethylbenzene production by 1.33% at the same ethylene conversion compared to the conventional condition.
Respiratory viral infections and associated neurological manifestations
Authors: Hosseini Shirin , Michaelsen-Preusse Kristin , Korte Martin 
Published: March 2021

Abstract
Respiratory viruses as a major threat to human and animal health today are still a leading cause of worldwide severe pandemics. Although the primary target tissue of these viruses is the lung, they can induce immediate or delayed neuropathological manifestations in humans and animals. Already after the Spanish flu (1918/20) evidence accumulated that neurological diseases can be induced by respiratory viral infections as some patients showed parkinsonism, seizures, or dementia. In the recent outbreak of COVID-19 as well patients suffered from headache, dizziness, nausea, or reduced sense of smell and taste suggesting that SARS-CoV2 may affect the central nervous system (CNS). It was shown that different respiratory viral infections can lead to deleterious complications in the CNS by a direct invasion of the virus into the brain and/or indirect pathways via proinflammatory cytokine expression. Therefore, we will discuss in this review mechanisms how the most prevalent respiratory viruses including influenza and coronaviruses in humans can exert long-lasting detrimental effects on the CNS and possible links to the development of neurodegenerative diseases as an enduring consequence.
Feasibility Analysis of Multimedia Technology Applied in Musical Drama Teaching Class—Taking the Teaching Practice of the Township Version of “Tang Xianzu” as an Example
Authors: Zhang Qing , Li Xiaorong 
Published: March 2021

Abstract
In today’s fast-developing society, information technology is widely used in various teaching fields, which has a major impact on education and teaching in all aspects. In the classroom teaching of musical dramas, the application of multimedia technology has greatly broadened the teaching philosophy of musical drama teachers and constantly changed the teaching mode of musical drama teaching classrooms. It also made music teachers have to improve their multimedia technology to adapt to modern teaching facilities. Multi-channel surround sound is an inevitable trend in the development of audio-visual technology and a perfect embodiment of art and technology. Multi-channel surround system is applied to multimedia teaching, which brings students a stronger sense of space, positioning, and layering. The impact of audition can fully stimulate students’ enthusiasm and interest in learning. Based on the mature multimedia teaching technology, this article studies the audio production processing technology related to it in detail. On this basis, the multi-channel surround sound of streaming media is also tracked and analyzed. The difference between the two determines the theoretical and technical gap between the two formats and elaborates on the procedures and steps for surround sound production. This article takes the teaching practice of the township version of “Tang Xianzu” as an example to design a multi-channel surround sound system. Multi-channel surround sound technology was introduced into the multimedia software production of the musical drama teaching class. A leap in the production level of multimedia software. It injects vitality into music quality education and broadens the application range of modern educational technology.
IACMI–The Composites Institute Efforts in Current and Post–COVID-19 Manufacturing Era—Innovations and Sustainability
Authors: Vaidya Uday , Hopkins John 
Published: March 2021

Abstract
Institute for Advanced Composites Manufacturing Innovation (IACMI)–The Composites Institute comprises 150 industry members making up the supply chain from material suppliers; Tiers 1, 2, and 3 original equipment manufacturer (OEM)s and fabricators; academia; and national laboratories. The institute is addressing the needs for medical systems support in response to the coronavirus 2019 (COVID-19) crisis and the recovery of the U.S. composites industry and connected manufacturing supply chains. The impact of the current and post-COVID response by IACMI and its partners extends across health care, automotive, transportation, construction, infrastructure, aerospace, sports, marine, and industrial sectors. Sustainability and circular economy of advanced materials and manufacturing play a key role in overall reduced embodied energy. This technical note provides a summary of IACMI efforts in response to COVID-19 and outlook for the post-COVID era with a focus on sustainable advanced materials and manufacturing.
Magnetoresistive Properties of Multilayer Film Systems Based on Permalloy and Silver
Authors: Pazukha I.M. , Shuliarenko D.O. , Dolgov-Gordiichuk S.R. , Odnodvorets L.V. 
Published: March 2021

In this paper, the experimental investigation focuses on the magnetoresistive properties of nanosized film systems. Their structure changes from layered to granular due to transition from bilayer FM/NM (FM is a ferromagnetic material, NM is a nonmagnetic material) to [FM/NM]n multilayer film at a constant total thickness of samples. As ferromagnetic and nonmagnetic materials were chosen permalloy Ni80Fe20 (Py) and Ag, respectively. It was demonstrated that the shape of the field dependences of magnetoresistance depends on the number of bilayer Py/Ag. For as-deposited [Py/Ag]n/S at n = 8, 16, the transition from the antiferromagnetic ordering of magnetic moments to ferromagnetic one occurs under an external magnetic field. As a result, the resistivity of the samples reduced, and the giant magnetoresistive effect was realized. The increase of the number of bilayers repeats from 2 to 16 at the unchanged total thickness of the system leads to the growth of the magnetoresistance from 0.1 % to 0.35 %. During annealing up to 600 K, the magnetoresistive effect is reduced, but it does not disappear completely
Sensitive and validated TLC densitometry method coupled with fluorescence detection for quantitative determination of the newly co-formulated drugs, celecoxib and amlodipine besylate in tablet dosage form
Authors: Rizk M. , Toubar S. , Ramzy E. , Helmy Marwa 
Published: March 2021

Abstract
New, sensitive, rapid, cost-effective, and validated stability-indicating thin layer chromatographic (TLC) method coupled with fluorescence (FL) detection was developed for the quantitative analysis of celecoxib (CEL) and amlodipine besylate (AMLO) in their laboratory prepared binary mixture using the non-fluorescent TLC silica gel 60 plates. Ethyl acetate: diethylamine: 1-propanol (9:1:0.2, V/V) was used as a developing system. The retention factor (Rf) for each drug was 0.80 ± 0.03 and 0.44 ± 0.01 for CEL and AMLO, respectively. The plates were excited at 264 nm for the simultaneous FL measurement of CEL and AMLO, the calibration curves were linear over a concentration ranges of 30.0–300.0 ng/band and 15.0–150.0 ng/band with mean percentage recoveries of 99.80 ± 0.85 and 99.80 ± 0.77 For CEL and AMLO, respectively. The developed method was applied for the stability studies of the cited drugs in their laboratory prepared binary mixture and the forced degradation products were determined when present in presence of the pure drugs so the method can be considered as a stability-indicating one and it was validated as per ICH guidelines and proved to be accurate and precise.
The changing face of Dentistry in the COVID-19 pandemic
Authors: Wood NH 
Published: March 2021

The year is drawing to a close and with it we present to you the final issue of the South African Dental Journal for 2020. This year saw us face the terrible COVID-19 pandemic. As oral healthcare practitioners we have been challenged in many ways, and this placed many of us under extreme pressure. Unfortunately we are just starting to see a new rise, or second wave, in the numbers of positive COVID-19 cases being reported. This means that the pressure is not about to be released, and we continue to navigate these uncharted waters into 2021.
In February we were uncertain about the impact of COVID-19 on our healthcare systems and our country, however we have now seen the course and the progression of this disease in many countries, and we know the reach it has and the devastating infection it causes. In light of this I am reminding you of the required infection control processes and procedures that need to be in place to protect yourself, co-workers and your patients.
Epidemiological profile of patients utilizing dental public health services in the eThekwini and uMgungundlovu districts of KwaZulu-Natal province, South Africa
Authors: Mthethwa Jimmy M , Mahomed Ozayr H , Yengopal Veerasamy 
Published: March 2021

INTRODUCTION: Oral conditions such as dental caries, periodontal diseases, tooth loss and trauma affect millions of people globally. These conditions can be prevented when detected early, thereby avoiding adverse outcomes. The prevalence of oral conditions has been reported in most provinces. However, there is a paucity of data in KwaZulu-Natal. AIM AND OBJECTIVE: This study aimed to determine the prevalence of oral conditions at public health facilities in two health districts in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: A cross-sectional analytical study design was used to determine the nature of oral conditions treated in dental facilities in the eThekwini and uMgungundlovu districts, in KwaZulu-Natal. The study was conducted over a 5-month period (November 2018 - April 2019). After clinicians examined the patients they entered the data in the patients clinical records and selected information (routine medical history questions as well as 16 possible diagnosis codes) were entered into a data extraction template. The data were analyzed using statistical software SPSS. RESULTS: Dental caries was the most prevalent oral condition at 66.4% followed by periodontal disease at 11.7%, trauma at 7.3% and lastly tooth loss at 5.9% CONCLUSION: These findings contribute to knowledge on the prevalence of these oral conditions found in the province.
Categoria nominal e abstracção (ou o porquê das sereias serem mais concretas que o ar)
Authors: Teixeira José 
Published: March 2021

O presente estudo tem por finalidade tentar demonstrar a não exequibilidade das tentativas de apresentação de critérios dualistas para a classificação tradicional concreto-abstracto na categoria gramatical nome. Depois de seren sintetizadas as visões tradicionais e respectivos critérios justificativos, apresentam-se os resultados de um inquérito (1403 inquiridos, 22448 respostas) que comprovam que a classificação concreto-abstracto apresenta graus de saliência variável, mas não aleatória, entre os falantes. A partir destes resultados e dentro de uma visão cognitiva do significado como resultante multimodal dos processos perceptivos do ser humano, explana-se um quadro justificativo das relações existentes entre as duas vertentes: mecanismos perceptivos utilizados na conceptualização do real e grau atribuído ao nome na escala concreto-abstracto.
PEMANFAATAN TEKNOLOGI FISH MACHINE SEPARATOR PADA UKM TAHU BAKSO BANDENG DESA BATURSARI
Authors: Oktoriza Linda Ayu , Widowati Amerti Irvin , Surjawati Surjawati 
Published: March 2021

Terdapat usaha yang dijalankan oleh para ibu rumah tangga yang ingin membantu keuangan keluarga, dengan cara mengolah ikan bandeng menjadi Tahu Bakso Bandeng. Berdasarkan hasil observasi dan diskusi dengan mitra terdapat beberapa masalah yang dihadapi pada usaha tersebut. Belum adanya teknologi yang masuk serta pengetahuan yang minimum mengenai higienitas, memiliki cukup andil dalam kendala menjalankan usaha tersebut. Masalah selanjutnya yang dihadapi mitra adalah masih mencampuradukan antara uang hasil usaha dengan uang untuk kebutuhan rumah tangga, sehingga sulit menentukan laba bersih.
Metode pendekatan yang digunakan adalah pendampingan yang dilakukan dengan brainstorming untuk membuka mindset tentang pentingnya memproduksi barang olahan pangan dengan menggunakan teknologi yang lebih efisien dan lebih bersih, serta menjaga higienitas. Selanjutnya penyuluhan tentang faktor penentu keberhasilan usaha pembuatan Tahu Bakso Bandeng ini, baik dalam produksi maupun manajemennya. Lalu, praktik yang akan diajarkan penggunaan teknologi dalam proses produksi, serta yang terakhir adalah pelatihan.
Luaran yang dihasilkan adalah meningkatkan keterampilan mitra antara lain: 1) Aspek produksi yaitu peningkatan kualitas dan kuantitas produk dengan memasukkan teknologi kedalam proses produksi, serta sistem produksi yang lebih efektif dan efisien serta selalu menjaga higienitas produk dengan cara menggunakan sarung tangan dan 2) Aspek pengelolaan keuangan usaha yaitu terpisahnya keuangan usaha dan keuangan rumah tangga dengan melakukan penggolongan, pencatatan, dan pembukuan sehingga mitra dapat menentukan laba usaha secara tepat.
STRATEGI MEMBANGUN BRANDING USAHA EKSPOR BRIKET ARANG TEMPURUNG KELAPA PADA UKM “BRIQCO”
Authors: Wulandari Retno , Anita Diyah Candra , Nugroho Hendrato Setiabudi 
Published: March 2021

Strategi Global Value Chain digunakan untuk menghadapi persaingan pasar global, sehingga UMKM mampu beradaptasi di pasar global. Tujuan yang ingin dicapai dalam program PPUD (Pengembangan Produk Unggulan Daerah) pada tahun ketiga ini, antara lain: penyelenggaraan Workshop Global Value Chain dan seluk-beluk ekspor impor, pembuatan aspek legalitas CV, pengurusan merk dagang BriqCo, pengurusan Izin Gangguan (IG), peningkatan branding melalui pembuatan website dan market place (Brand Awarness) serta penambahan mesin produksi. Metode yang dilakukan melalui rapat koordinasi, pelatihan dan simulasi, pembuatan alat dengan alih teknologi guna efisiensi produksi, pengurusan legalitas dan paten serta pembuatan website. Hasil implementasi yang dilakukan pada bulan Maret – Agustus 2020 antara lain tercapainya efisiensi produksi limbah briket arang tempurung kelapa sekaligus alih teknologi dengan membuat oven pengeringan dengan penambahan bowler, terbentuknya kesadaran diri tentang pentingnya pajak dan aspek legalitas usaha BriqCo, peningkatan branding usaha melalui pembuatan website perusahaan, telah tersedianya akta notaris perusahaan. Luaran dalam program pengabdian masyarakat ini adalah bertambahnya jumlah karyawan dari 38 orang menjadi 41 orang karyawan, owner meningkat pengetahuan perpajakan, efisiensi produksi limbah briket dengan produksi bara-bara, peningkatan branding dengan adanya website dan legalitas usaha CV serta persiapan relokasi pabrik.
OPTIMALISASI PENGELOLAAN ADMINISTRASI DAN SISTEM INFORMASI DESA PONCOSARI UNTUK MENINGKATKAN EFISIENSI PELAYANAN KEPADA MASYARAKAT
Authors: Sugito Sugito , Anam Muhammad Zahrul 
Published: March 2021

Pengelolaan administrasi kependudukan dan Sistem Informasi Desa (SID) Poncosari belum dilakukan secara optimal. Hal ini dikarenakan kurangnya petugas website, minimnya keterampilan jurnalisme dan fotografi, serta kurangnya pengetahuan teknis dari aparat dusun dalam tertib adminitrasi. Pengabdian dilakukan dengan menggunakan metode penyuluhan, pelatihan, dan pendampingan yang melibatkan masyarakat secara aktif dan bekerja sama dengan KKN Mahasiswa UMY 74 dan 88 di Desa Poncosari. Kegiatan yang dilakukan adalah penyuluhan dan pelatihan administrasi kependudukan, pelatihan adminitrasi, dan penyusunan proposal kegiatan bagi karang taruna, serta pelatihan pendampingan jurnalistik warga dan fotografi. Pengabdian ini telah meningkatkan kemampuan jurnalistik, fotografi, dan tata kelola administrasi sehingga dapat mengotimalkan pengelolaan web desa dan SID Poncosari. Tindak lanjut dari pengabdian ini adalah pendampingan pengelolaan website desa dan pengembangan literasi media serta peningkatan pengelolaan potensi wisata di Desa Poncosari.