bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measures of prefrontal functional near-infrared spectroscopy in visuomotor learning
Authors: Tinga Angelica M. , Clim Maria-Alena , de Back Tycho T. , Louwerse Max M. 
Published: February 2021

AbstractFunctional near-infrared spectroscopy (fNIRS) is a promising technique for non-invasively assessing cortical brain activity during learning. This technique is safe, portable, and, compared to other imaging techniques, relatively robust to head motion, ocular and muscular artifacts and environmental noise. Moreover, the spatial resolution of fNIRS is superior to electroencephalography (EEG), a more commonly applied technique for measuring brain activity non-invasively during learning. Outcomes from fNIRS measures during learning might therefore be both sensitive to learning and to feedback on learning, in a different way than EEG. However, few studies have examined fNIRS outcomes in learning and no study to date additionally examined the effects of feedback. To address this apparent gap in the literature, the current study examined prefrontal cortex activity measured through fNIRS during visuomotor learning and how this measure is affected by task feedback. Activity in the prefrontal cortex decreased over the course of learning while being unaffected by task feedback. The findings demonstrate that fNIRS in the prefrontal cortex is valuable for assessing visuomotor learning and that this measure is robust to task feedback. The current study highlights the potential of fNIRS in assessing learning even under different task feedback conditions.
Improved in vivo PET imaging of the adenosine A2A receptor in the brain using [18F]FLUDA, a deuterated radiotracer with high metabolic stability
Authors: Lai Thu Hang , Toussaint Magali , Teodoro Rodrigo , Dukić-Stefanović Sladjana , Gündel Daniel , Ludwig Friedrich-Alexander , Wenzel Barbara , Schröder Susann , Sattler Bernhard , Moldovan Rareş-Petru , Falkenburger Björn H. , Sabri Osama , Deuther-Conrad Winnie , Brust Peter 
Published: February 2021

Abstract
Purpose
The adenosine A2A receptor has emerged as a therapeutic target for multiple diseases, and thus the non-invasive imaging of the expression or occupancy of the A2A receptor has potential to contribute to diagnosis and drug development. We aimed at the development of a metabolically stable A2A receptor radiotracer and report herein the preclinical evaluation of [18F]FLUDA, a deuterated isotopologue of [18F]FESCH.

Methods
[18F]FLUDA was synthesized by a two-step one-pot approach and evaluated in vitro by autoradiographic studies as well as in vivo by metabolism and dynamic PET/MRI studies in mice and piglets under baseline and blocking conditions. A single-dose toxicity study was performed in rats.

Results
[18F]FLUDA was obtained with a radiochemical yield of 19% and molar activities of 72–180 GBq/μmol. Autoradiography proved A2A receptor–specific accumulation of [18F]FLUDA in the striatum of a mouse and pig brain. In vivo evaluation in mice revealed improved stability of [18F]FLUDA compared to that of [18F]FESCH, resulting in the absence of brain-penetrant radiometabolites. Furthermore, the radiometabolites detected in piglets are expected to have a low tendency for brain penetration. PET/MRI studies confirmed high specific binding of [18F]FLUDA towards striatal A2A receptor with a maximum specific-to-non-specific binding ratio in mice of 8.3. The toxicity study revealed no adverse effects of FLUDA up to 30 μg/kg, ~ 4000-fold the dose applied in human PET studies using [18F]FLUDA.

Conclusions
The new radiotracer [18F]FLUDA is suitable to detect the availability of the A2A receptor in the brain with high target specificity. It is regarded ready for human application.
Open conversion in laparoscopic cholecystectomy and bile duct exploration: subspecialisation safely reduces the conversion rates
Authors: Nassar Ahmad H. M. , Zanati Hisham El , Ng Hwei J. , Khan Khurram S. , Wood Colin 
Published: February 2021

Abstract
Background
Open conversion rates during laparoscopic cholecystectomy vary depending on many factors. Surgeon experience and operative difficulty influence the decision to convert on the grounds of patient safety but occasionally due to technical factors. We aim to evaluate the difficulties leading to conversion, the strategies used to minimise this event and how subspecialisation influenced conversion rates over time.

Methods
Prospectively collected data from 5738 laparoscopic cholecystectomies performed by a single surgeon over 28 years was analysed. Routine intraoperative cholangiography and common bile duct exploration when indicated are utilised. Patients undergoing conversion, fundus first dissection or subtotal cholecystectomy were identified and the causes and outcomes compared to those in the literature.

Results
28 patients underwent conversion to open cholecystectomy (0.49%). Morbidity was relatively high (33%). 16 of the 28 patients (57%) had undergone bile duct exploration. The most common causes of conversion in our series were dense adhesions (9/28, 32%) and impacted bile duct stones (7/28, 25%). 173 patients underwent fundus first cholecystectomy (FFC) (3%) and 6 subtotal cholecystectomy (0.1%). Morbidity was 17.3% for the FFC and no complications were encountered in the subtotal cholecystectomy patients. These salvage techniques have reduced our conversion rate from a potential 3.5% to 0.49%.

Conclusion
Although open conversion should not be seen as a failure, it carries a high morbidity and should only be performed when other strategies have failed. Subspecialisation and a high emergency case volume together with FFC and subtotal cholecystectomy as salvage strategies can reduce conversion and its morbidity in difficult cholecystectomies.
Verification of randomized consensus algorithms under round-rigid adversaries
Authors: Bertrand Nathalie , Konnov Igor , Lazić Marijana , Widder Josef 
Published: February 2021

AbstractRandomized fault-tolerant distributed algorithms pose a number of challenges for automated verification: (i) parameterization in the number of processes and faults, (ii) randomized choices and probabilistic properties, and (iii) an unbounded number of asynchronous rounds. This combination makes verification hard. Challenge (i) was recently addressed in the framework of threshold automata. We extend threshold automata to model randomized consensus algorithms that perform an unbounded number of asynchronous rounds. For non-probabilistic properties, we show that it is necessary and sufficient to verify these properties under round-rigid schedules, that is, schedules where processes enter round ronly after all processes finished round$$r-1$$r-1. For almost-sure termination, we analyze these algorithms under round-rigid adversaries, that is, fair adversaries that only generate round-rigid schedules. This allows us to do compositional and inductive reasoning that reduces verification of the asynchronous multi-round algorithms to model checking of a one-round threshold automaton. We apply this framework and automatically verify the following classic algorithms: Ben-Or’s and Bracha’s seminal consensus algorithms for crashes and Byzantine faults, 2-set agreement for crash faults, and RS-Bosco for the Byzantine case.
Anthropogenic and geogenic influences on peri-urban aquifers in semi-arid regions: insights from a case study in northeast Jaipur, Rajasthan, India
Authors: Frommen Theresa , Groeschke Maike , Nölscher Maximilian , Koeniger Paul , Schneider Michael 
Published: February 2021

AbstractRapid urbanization has exerted considerable pressure on groundwater resources in Jaipur, India. Peri-urban areas are particularly affected as the public supply infrastructure often does not reach this fast-growing fringe, which often lacks a planning strategy, leading to an informal water supply based on groundwater. At the same time, the hills and historic reservoirs located in these areas are important for groundwater recharge and, therefore, critical for sustainable groundwater-resource management. To understand the local hydrogeology and the role of anthropogenic influences, a 2-year field study was carried out in northeastern Jaipur. The aim was to develop a conceptual model on which a management concept can be built. The study comprised hydrochemical and stable isotope analyses of water samples, depth-to-water measurements, a leveling survey and geophysical investigations. The study revealed that the groundwater from both the Proterozoic hard rock and the overlying Quaternary alluvial aquifer generally does not meet the Indian drinking water thresholds for nitrate concentration and/or total dissolved solids (TDS). While anthropogenic activities are the main source of quantity problems (declining groundwater levels through overabstraction), the biggest quality problems (nitrate up to 550 mg/L and TDS >500 mg/L) are most likely of geogenic origin and only enhanced by anthropogenic impacts. Quantity and quality aspects improve significantly in areas influenced by recharge from the historic reservoirs, leading to the conclusion that artificial recharge structures may be the way forward to improving community water supply and that groundwater protection should be given priority in these areas.
Hydrogenative-PHIP polarized metabolites for biological studies
Authors: Reineri Francesca , Cavallari Eleonora , Carrera Carla , Aime Silvio 
Published: February 2021

AbstractParaHydrogen induced polarization (PHIP) is an efficient and cost-effective hyperpolarization method, but its application to biological investigations has been hampered, so far, due to chemical challenges. PHIP is obtained by means of the addition of hydrogen, enriched in the para-spin isomer, to an unsaturated substrate. Both hydrogen atoms must be transferred to the same substrate, in a pairwise manner, by a suitable hydrogenation catalyst; therefore, a de-hydrogenated precursor of the target molecule is necessary. This has strongly limited the number of parahydrogen polarized substrates. The non-hydrogenative approach brilliantly circumvents this central issue, but has not been translated to in-vivo yet. Recent advancements in hydrogenative PHIP (h-PHIP) considerably widened the possibility to hyperpolarize metabolites and, in this review, we will focus on substrates that have been obtained by means of this method and used in vivo. Attention will also be paid to the requirements that must be met and on the issues that have still to be tackled to obtain further improvements and to push PHIP substrates in biological applications.
Reliable distribution of computational load in robot teams
Authors: Valkov Ivan , Trinder Phil , Chechina Natalia 
Published: February 2021

AbstractModern multi-robot systems often need to solve computationally intensive tasks but operate with limited compute resources and in the presence of failures. Cooperating to share computational tasks between robots at the edge reduces execution time. We introduce and evaluate a new computation load management technology for teams of robots: Reliable Autonomous Mobile Programs (RAMPs). RAMPs use information about the computational resources available in the team and a cost model to decide where to execute. RAMPs are implemented in ROS on a collection of Raspberry Pi-based robots. The performance of RAMPs is evaluated using route planning, a typical computationally-intensive robotics application. A systematic study of RAMPs demonstrates a high likelihood of optimal or near-optimal distribution and hence efficient resource utilisation. RAMPs successfully complete in the presence of simultaneous, or successive, robot failures and network failures, while preserving near-optimal distribution.
Give more data, awareness and control to individual citizens, and they will help COVID-19 containment
Authors: Nanni Mirco , Andrienko Gennady , Barabási Albert-László , Boldrini Chiara , Bonchi Francesco , Cattuto Ciro , Chiaromonte Francesca , Comandé Giovanni , Conti Marco , Coté Mark , Dignum Frank , Dignum Virginia , Domingo-Ferrer Josep , Ferragina Paolo , Giannotti Fosca , Guidotti Riccardo , Helbing Dirk , Kaski Kimmo , Kertesz Janos , Lehmann Sune , Lepri Bruno , Lukowicz Paul , Matwin Stan , Jiménez David Megías , Monreale Anna , Morik Katharina , Oliver Nuria , Passarella Andrea , Passerini Andrea , Pedreschi Dino , Pentland Alex , Pianesi Fabio , Pratesi Francesca , Rinzivillo Salvatore , Ruggieri Salvatore , Siebes Arno , Torra Vicenc , Trasarti Roberto , Hoven Jeroen van den , Vespignani Alessandro 
Published: February 2021

AbstractThe rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the “phase 2” of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens’ privacy and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens’ “personal data stores”, to be shared separately and selectively (e.g., with a backend system, but possibly also with other citizens), voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allow the user to share spatio-temporal aggregates—if and when they want and for specific aims—with health authorities, for instance. Second, we favour a longer-term pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society.
Sharing (mis) information on social networking sites. An exploration of the norms for distributing content authored by others
Authors: Marin Lavinia 
Published: February 2021

AbstractThis article explores the norms that govern regular users’ acts of sharing content on social networking sites. Many debates on how to counteract misinformation on Social Networking Sites focus on the epistemic norms of testimony, implicitly assuming that the users’ acts of sharing should fall under the same norms as those for posting original content. I challenge this assumption by proposing a non-epistemic interpretation of (mis) information sharing on social networking sites which I construe as infrastructures for forms of life found online. Misinformation sharing belongs more in the realm of rumour spreading and gossiping rather than in the information-giving language games. However, the norms for sharing cannot be fixed in advance, as these emerge at the interaction between the platforms’ explicit rules, local norms established by user practices, and a meta-norm of sociality. This unpredictability does not leave us with a normative void as an important user responsibility still remains, namely that of making the context of the sharing gesture explicit. If users will clarify how their gestures of sharing are meant to be interpreted by others, they will implicitly assume responsibility for possible misunderstandings based on omissions, and the harms of shared misinformation can be diminished.
Influence of VEGF-A, VEGFR-1-3, and neuropilin 1-2 on progression-free: and overall survival in WHO grade II and III meningioma patients
Authors: Bernatz Simon , Monden Daniel , Gessler Florian , Radic Tijana , Hattingen Elke , Senft Christian , Seifert Volker , Ronellenfitsch Michael W. , Plate Karl H. , Harter Patrick N. , Baumgarten Peter 
Published: February 2021

AbstractHigher grade meningiomas tend to recur. We aimed to evaluate protein levels of vascular endothelial growth factor (VEGF)-A with the VEGF-receptors 1-3 and the co-receptors Neuropilin (NRP)-1 and -2 in WHO grade II and III meningiomas to elucidate the rationale for targeted treatments. We investigated 232 specimens of 147 patients suffering from cranial meningioma, including recurrent tumors. Immunohistochemistry for VEGF-A, VEGFR-1-3, and NRP-1/-2 was performed on tissue micro arrays. We applied a semiquantitative score (staining intensity x frequency). VEGF-A, VEGFR-1-3, and NRP-1 were heterogeneously expressed. NRP-2 was mainly absent. We demonstrated a significant increase of VEGF-A levels on tumor cells in WHO grade III meningiomas (p = 0.0098). We found a positive correlation between expression levels of VEGF-A and VEGFR-1 on tumor cells and vessels (p < 0.0001). In addition, there was a positive correlation of VEGF-A and VEGFR-3 expression on tumor vessels (p = 0.0034). VEGFR-2 expression was positively associated with progression-free survival (p = 0.0340). VEGF-A on tumor cells was negatively correlated with overall survival (p = 0.0084). The VEGF-A-driven system of tumor angiogenesis might still present a suitable target for adjuvant therapy in malignant meningioma disease. However, its role in malignant tumor progression may not be as crucial as expected. The value of comprehensive testing of the ligand and all receptors prior to administration of anti-angiogenic therapy needs to be evaluated in clinical trials.
CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice
Authors: Liu Hailin , Hu Xiangnan , Jiang Rong , Cai Jianghui , Lin Qiao , Fan Zhiguo , Zhao Pan , Wang Song , Zou Chunqiao , Du Weimin , Dong Zhi , Liu Yingju 
Published: February 2021

Abstract
Excessive microglial activation-mediated neuroinflammation is closely involved in the pathogenesis of several neurological diseases. CQMUH-011, as a novel adamantane sulfonamide compound, has been shown anti-inflammatory properties in activated macrophages (RAW264.7). However, the role of CQMUH-011 in microglial activation-induced neuroinflammation and neuroprotective properties has yet to be elucidated. In the present study, we investigated the potential effects and mechanisms of CQMUH-011 on lipopolysaccharide (LPS)-stimulated primary microglia in vitro and transient middle cerebral artery occlusion (t-MCAO)–induced acute cerebral ischemia/reperfusion (I/R) injury in vivo. The results demonstrated that CQMUH-011 significantly suppressed the production of tumor necrosis factor (TNF)-α and interleukin (IL)-1β by LPS-stimulated primary microglia. In addition, CQMUH-011 inhibited the proliferation of activated microglia by arresting the cell cycle at the G1/S phase accompanied by downregulating the expression of cell cycle regulatory proteins such as proliferating cell nuclear antigen (PCNA) and cyclin D1. CQMUH-011 was seen to induce apoptosis in activated microglia by regulating the expression of Bax and Bcl-2. Furthermore, CQMUH-011 markedly attenuated the protein expression of Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88) as well as the phosphorylation levels of nuclear factor-kappa (NF-κB) subunit p65, inhibitory kappa B-alpha (IκBα), and mitogen-activated protein kinases (MAPKs) such as extracellular signal-regulated kinase (ERK) and p38 kinases. In vivo, CQMUH-011 administration significantly improved neurological function and infarct volume, and ameliorated the inflammatory cytokines and microglia amount around the injury site of mice. In conclusion, these results suggested that CQMUH-011 has a notable anti-inflammatory effect and protects mice from I/R injure. Thus, CQMUH-011 may be a candidate drug for the treatment of cerebral ischemia patients.
Calibration and Uncertainty Estimation for Water Content Measurement in Solids
Authors: Aro Rudolf , Ayoub Mohamed Wajdi Ben , Leito Ivo , Georgin Éric , Savanier Benoit 
Published: February 2021

AbstractIn the field of water content measurement, the calibration of coulometric methods (e.g., coulometric Karl Fischer titration or evolved water vapor analysis) is often overlooked. However, as coulometric water content measurement methods are used to calibrate secondary methods, their results must be obtained with the highest degree of confidence. The utility of calibrating such instruments has been recently demonstrated. Both single and multiple point calibration methods have been suggested. This work compares these calibration methods for the evolved water vapor analysis technique. Two uncertainty estimation approaches (Kragten’s spreadsheet and M-CARE software tool) were compared as well, both based on the ISO GUM method.
Social Media Adoption, Usage And Impact In Business-To-Business (B2B) Context: A State-Of-The-Art Literature Review
Authors: Dwivedi Yogesh K. , Ismagilova Elvira , Rana Nripendra P. , Raman Ramakrishnan 
Published: February 2021

AbstractSocial media plays an important part in the digital transformation of businesses. This research provides a comprehensive analysis of the use of social media by business-to-business (B2B) companies. The current study focuses on the number of aspects of social media such as the effect of social media, social media tools, social media use, adoption of social media use and its barriers, social media strategies, and measuring the effectiveness of use of social media. This research provides a valuable synthesis of the relevant literature on social media in B2B context by analysing, performing weight analysis and discussing the key findings from existing research on social media. The findings of this study can be used as an informative framework on social media for both, academic and practitioners.