bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of clinical and anamnestic characteristics and treatment of patients with hypertriglyceridemia (the data from Kuzbass register of dyslipidemias)
Authors: Sedykh D. Yu. , Hryachkova O. N. , Kashtalap V. V. , Barbarash O. L. 
Published: September 2021

Aim. To study the features of clinical and anamnestic characteristics and treatment of patients with hypertriglyceridemia (HTG) using the data of the lipid control center of Kemerovo.Methods. The single-center retrospective study is based on the data of patients dynamic observation (n = 100) in the Dyslipidemia Registry of Kuzbass in 2019. A comparative analysis of clinical and anamnestic characteristics, lipidogram parameters and therapy was performed at the time when the patients were included in the study and after 6–12 months in patients with HTG (the criterion was the level of triglycerides (TG) above 1.69 mmol/L) and in patients without it. Indications for consulting a lipidologist were high cholesterol (levels of total cholesterol (TC) ˃7.5 mmol/L or low-density lipoprotein cholesterol ˃4.9 mmol/L or TG˃5 mmol/L), requirement of the high dose and/or combination therapy of lipid-lowering drugs; medical history of cardiovascular diseases and/or revascularization of vascular bed in patients under 55 years of age; suspected intolerance to lipid-lowering therapy due to the developed side effects; the issue of lipid-lowering therapy in complex clinical situations.Results. Among the patients who visited a lipidologist in 2019, mixed hypertriglyceridemia was noted in 56 (56%) of cases, while 44 (44%) patients had other lipid metabolism disorders without increased levels of TG. A distinctive feature of patients with mixed hypertriglyceridemia is the lower incidence of myocardial infarctions (p = 0.029) and lower number of coronary stents (p = 0.018) in the medical history, despite the initially higher levels of TC (p = 0.005) and TG (p = 0.000). According to the results of 6–12 months observation, a significant decrease in TC (p = 0.001) and TG (p = 0.044) levels during the lipid-lowering therapy was revealed due to the addition of fenofibrate (p = 0.000) to all groups of patients who were monitored by a lipidologist.Conclusion. The patients with dyslipidemia and HTG are a complex category of patients who require combined lipid-lowering therapy, which can only be prescribed by a lipidologist.
Management of patients with atherosclerotic lower extremity peripheral arterial disease in the outpatient setting
Authors: Makarov S. A. , Smirnov K. V. 
Published: September 2021

Aim. To analyze and scientifically substantiate the need for the creation of a program for the outpatient observation with COZANC using remote patronage.Methods. The study prospectively included 150 patients with atherosclerosis of the arteries of the lower extremities. The average age of the patients was 68.3 ± 9.7 years. Clinical and anamnestic data were studied, and patients were interviewed using questionnaires and scales. Two observation groups were formed: the main one consisted of 70 patients, who were included in the program of remote patronage clinical examination, and 80 patients were under the standard model of outpatient observation with COZANC.Results. For a 3-month period of outpatient observation, an audio communication session was carried out for 70 patients, once a month. During the reporting period, no acute cardiovascular events were recorded in the main group, while in the comparison group there were 3 (3.75%) myocardial infarctions. The development of CLI occurred in the main group in 1 case, while in the comparison group there were 4 (5%) patients, in one case the lower limb was amputated. In the comparison group, there were 3 ischemic events that resulted in a lethal outcome.Conclusion. For the first time, a personalized remote patronage program was created and introduced into clinical practice at the level of primary health care, as a tool for optimizing the clinical examination program for patients with COZANC. The effectiveness of the remote patronage program for patients with atherosclerosis of the arteries of the lower extremities is described in relation to the prevention of acute cardiovascular events and the progression of COZANC.
"Portrait" of patients with pulmonary hypertension, associated with mitral valve diseases before cardiac surgery
Authors: Teplova Yu. E. , Lyapina I. N. , Shaleva V. A. , Kuzmina O. K. , Evtushenko A. V. , Barbarash O. L. 
Published: September 2021

Aim. To study “the portrait” of patients with acquired mitral valve (MV) heart disease of various origins and pulmonary hypertension hospitalized for surgical correction of the defect.Methods. The study included 97 patients with acquired diseases of mitral valve and pulmonary hypertension. The assessment of demographic, clinical and anamnestic data, indicators of transthoracic echocardiography, quality of life before the correction of MV defect was carried out.Results. The studied cohort is mostly represented by female patients (n = 70; 72.2%). The most common cause of mitral valve disease was rheumatic heart disease (n = 40; 41.2%). Overweight, hypertension (n = 76; 78.4%) and atrial fibrillation (n = 62; 63.9%) were the most common comorbidities. The mean pressure level in the pulmonary artery according to echocardiography was 35.5 (29.0; 40.0) mm Hg, with no significant difference among the patients, regardless the mitral defect etiology. Less pronounced remodeling of the left ventricle was noted in patients with rheumatic heart disease, which is caused by a lesion of the MV by the type of stenosis in contrast to patients with connective tissue dysplasia syndrome or against the background of detachment of MV chords with MV damage in the form of its insufficiency. There were no significant differences in the systolic function of the right ventricle depending on the etiology of MV defect.Conclusion. The “portrait” of a patient with pulmonary hypertension associated with an acquired mitral valve defect before its correction is the predominance of female, overweight, with II or III functional class of chronic heart failure, more frequent rheumatic genesis of MV defect, the presence of concomitant pathology in the form of hypertension and persistent atrial fibrillation, and increased size of the left atrium and left ventricle, reduced systolic function of the right ventricle according to the data of Echocardiography.
Development of personalized cell-populated vascular graft in vitro
Authors: Khanova M. Yu. , Velikanova E. A. , Glushkova T. V. , Matveeva V. G. 
Published: September 2021

Aim. To create a personalized cell-populated small-diameter vascular prosthesis in a pulsating bioreactor.Methods. Tubular grafts were made by electrospinning from mixtures of biodegradable polymers, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(εcaprolactone) (PCL). The inner surface is modified with fibrin. Tubular scaffolds were colonized with cultured colony-forming endothelial cells and grown under static conditions for 2 days. Then, the cell-populated prostheses continued to be cultivated for 5 days in a pulsating bioreactor system with a final shear stress of 2.85 dynes/cm².Results. The advantages of the cultivation of cell-populated vascular prostheses in a pulsating bioreactor have been revealed. The selected mode of cultivation of cellpopulated vascular prostheses under conditions of a pulsating flow with a shear stress of 2.85 dynes/cm² did not have a damaging effect on the integrity of the endothelial monolayer. Moving unidirectional mechanical stimuli of chaotic orientation fibers of F-actin changed to a predominant orientation in the direction of flow, and also increased the expression of F-actin, Talin focal adhesion protein, and specific endothelial markers CD309, CD31, vWF.Conclusion. The creation of a personalized cell-populated small-diameter vascular prosthesis with a functional endothelial monolayer is possible due to the use of autologous endothelial cells, autologous fibrin, and cultivation under conditions of a pulsating flow.
Gender differences in cardiometabolic risks among young adults
Authors: Chulkov V. S. , Lenets E. A. , Gavrilova E. S. , Minina E. E. , Pozdeeva V. A. , Ukolov N. D. 
Published: September 2021

Aim. To carry out a comparative assessment of cardiometabolic risk factors in men and women aged 18–44 years.Methods. The cross-sectional study included 251 patients divided into 2 groups. Group 1 consisted of 124 men; group 2 had 127 women in it. All participants of the study underwent anamnesis collection, blood pressure measurement, and assessment of anthropometric parameters, physical examination, biochemical and immunological tests.Results. The most significant gender differences were noted in the levels of leptin and adiponectin, fibrinogen and plasminogen activator inhibitor type 1, angiotensin II and interleukin-10 in the blood serum with no differences in cardiometabolic risk factors, including glucose and lipid metabolism.Conclusion. The revealed features of changes in adipokines and cytokines, indicators of hemostasis and vasoconstrictors in men and women expand the current knowledge about the role of some pathophysiological mechanisms in the development of cardiovascular pathology at a young age in the context of cardiometabolic risk concept.
The features of early rehabilitation in patients after surgical repair of valvular heart disease
Authors: Shaleva V. A. , Lyapina I. N. , Teplova Yu. E. , Pomeshkina S. A. , Barbarash O. L. 
Published: September 2021

Aim. To develop and evaluate the safety/efficacy of an early rehabilitation program with physical aerobic training in patients after surgical repair of acquired valvular heart disease.Methods. The study included 45 patients with valvular heart disease undergoing surgical repair. Patients in the group (n = 30) underwent a standard cardiac rehabilitation after the surgery; on the 8th day after the surgery patients in the main group (n = 15) in addition to the standard cardiac rehabilitation were involved in personalized aerobic physical training on a treadmill prescribed according to the cardiopulmonary exercise testing results (spiroveloergometry). The duration of the training on a treadmill was 14 days.Results. The rhythm changing, life-threatening heart rhythm disorders, episodes of ischemia, desaturation were not recorded during the training. The main reason to stop the training was the weakness and fatigue of the patients. There were no disturbances of intracardiac hemodynamic after the course of physical training. In the main group there was a significant increase in exercise tolerance from 50.0 [25.0; 75.0] to 75.0 [50.0; 100.0] W (p = 0.04), close to significant increase in VO2peak from 10.9 [9.6; 13.3] to 12.3 [10.6; 14.9] ml/kg/min (p = 0.07).Conclusion. The 14-days program of early rehabilitation with aerobic training after surgical repair of valvular heart disease has demonstrated its safety and influenced the increase in exercise tolerance, peak oxygen consumption.
USTClitho2.0: Updated Unified Seismic Tomography Models for Continental China Lithosphere from Joint Inversion of Body-Wave Arrival Times and Surface-Wave Dispersion Data
Authors: Han Shoucheng , Zhang Haijiang , Xin Hailiang , Shen Weisen , Yao Huajian 
Published: September 2021

Abstract
Xin et al. (2019) presented 3D seismic velocity models (VP and VS) of crust and uppermost mantle of continental China using seismic body-wave travel-time tomography, which are referred to as Unified Seismic Tomography Models for Continental China Lithosphere 1.0 (USTClitho1.0). Compared with previous models of continental China, the VP and VS models of USTClitho1.0 have the highest spatial resolution of 0.5°–1.0° in the horizontal direction and are useful for better understanding the complex tectonics of continental China. Although USTClitho1.0 is implicitly constrained by surface-wave data by using the VS model from surface-wave tomography and the converted VP model as initial models for body-wave travel-time tomography, the predicted surface-wave dispersion curves from USTClitho1.0 do not fit the observed data well. Here, we present updated 3D VP and VS models of the continental China lithosphere (USTClitho2.0) by joint inversion of body-wave arrival times and surface-wave dispersion data. Compared with the previous joint inversion scheme of Zhang et al. (2014), similar to Fang et al. (2016), it is further improved by including the sensitivity of surface-wave dispersion data to VP in the new joint inversion system. As a result, the shallow VP structure is also better imaged. In addition, the new joint inversion scheme considers the large topography variations between the eastern and western parts of China. Thus, USTClitho2.0 better resolves the upper-crustal structure of the Tibetan plateau. Compared with USTClitho1.0, USTClitho2.0 fits both body-wave arrival times and surface-wave dispersion data. Thus, the new velocity models are more accurate and can serve as a better reference model for regional-scale tomography and geodynamic studies in continental China.
A rare case of protein C mutation causing neonatal purpura fulminans
Authors: Tawab Abdul , George Madhu , Joseph Jino , Zacharias Ann Mary 
Published: September 2021

Congenital protein C deficiency presenting as purpura fulminans is a rare condition in neonates. It is a disorder with autosomal recessive inheritance and is caused by homozygous or compound heterozygous mutations in PROC gene. The authors report a case of autosomal homozygous PROC gene transversion mutation in a newborn baby born to third degree consanguineous parents who presented as purpura fulminans at birth. She had almost undetectable protein C levels. As protein C concentrate was not readily available, she was managed with low molecular weight heparin along with fresh frozen plasma. Despite our best efforts, baby succumbed to her illness on day 21 of life. Autosomal recessive protein C deficiency should always be sought as an explanation for thrombotic disorders in the newborn with manifestations of disseminated intravascular coagulation.
Literary Philosophy and the Use of Uselessness
Authors: Jarvie Scott A , Frattura Addyson 
Published: September 2021

We build this work from the memory of the time we stumbled into tulips at city hall. As guard sirens fled off into the night, we wondered, “Maybe we can borrow some.” We ripped handfuls from the ground and ran. “Don’t worry,” we said, “they are too busy to catch us stealing tulips.” Likewise, we get away with this useless project because others are busy doing useful work: exigent, coherent, important work. We support much of that busyness, and at the same time wonder what is lost with all that attention towards usefulness. What we offer here, through a hybrid of reflective, poetic, essayistic and scholarly forms, may be an attempted escape from the obligations of scholarship. It may be indulgent. It may tell the reader nothing, or only what the reader already knows. Yet it is oriented towards an enduring promise. This is the promise of a literary experience, understood as a kind of resonance, ineffable primarily, but nevertheless one that matters. Such a promise is found in the power and possibility of story, through poetic lines that must be broken and conceptual tethers left incommensurable. We enter this space of breaking and unfurling through an inquiry into use.

The question of use and uselessness is one way of holding human contradictions in both hands. By this we mean that we make and leave space for literary and philosophical inquiries considered useless—in that they do not resolve anything—but nevertheless matterful. We suggest that readers meander these curated pages as they \ meander through an art exhibition or a museum. Within a literary exhibition one can wander through pages, spaces, and ideas. Pause. Dwell. Think. We curate a literary home beyond the demands of making something of use and we invite the reader to sit with us. As with an exhibition, possibility cannot be controlled for and so we exist in potentiality acknowledging both its positive and negative potential. Through our use, misuse, and abuse of literature and philosophy, we make ourselves a home in a possibility that can only be offered, not demanded. We manifest this literary home through fragments of philosophy evoked through a series of microfictions.

As scholars, learners, teachers, and writers we are often asked to defend what our writing does. And it is implicitly suggested that knowledge creation is the result. What is the use of a work that cannot promise new knowledge? Literary knowledge may only be one gorgeous possible ordering. It is a practice which produces a kind of knowledge which is no knowledge, which is useless. If we must answer what it is that our writing does we suppose that—if anything—it offers up fictions for philosophizing. We explore a home for this work in scholarly contexts which too often find it useless, which is to say we position uselessness as a concept of value for our work as scholars, writers, and teachers. In the end we name no new uses but fiction; we steal tulips.
Analysis of Fractures and Disability Defects Accidents in Lian Oil Company by Tripod Beta Technique
Authors: Akhavan A , Salehi Reyhani SH , Halvani Gh 
Published: September 2021

Introduction: Undoubtedly, the first step in controlling accidents is to analyze them to identify the root causes. In this study, the root causes of accidents leading to severe consequences have been analyzed using the beta tripod technique in Lian Oil Company.
Materials and Methods: The research method is descriptive-analytical. In this research, the events of 2020 in two barrel-making and barrel filling units of Lian Oil Refining and Trade Company have been investigated. The tripod-beta method is one of the methods of tracing the roots of accidents, which is widely used in the oil industry because of its special attitude towards the element of human error. Using investigator software, a tripod beta diagram related to three fracture and disability accidents was drawn and after recording and identifying the relevant causes and obstacles, corrective measures were taken to prevent similar accidents. The basis of accident control is the creation of appropriate control and defense systems in such a way as to prevent the interconnection and interaction of the risk factor and the target factor.
Results: The results of this study show that non-compliance with safety principles due to reduced staff awareness and lack of long-term and short-term training are the root causes of accidents studied and had the highest impact on these events. 45% of cases were related to the cause of the accident. Other cases after training have had almost the same effect on the occurrence of events. Each of the cases accounted for 11% of the causes of the accidents.
Conclusion: Beta tripod technique is currently one of the best methods for tracing the roots of accidents. The results also indicate that effective measures in the normal time phase, i.e. employing more talented people, conducting training at the beginning of employment, and upstream perspective, i.e. operator coordination with hardware and methods of implementation in the phase of ideas and thinking and design will greatly prevent accidents.
Occupational accidents in Yazd University of Medical Sciences hospitals
Authors: Hajimaghsoudi M , Dehghani MH , Sadooghian M 
Published: September 2021

Introduction: Health care workers are exposed to numerous occupational accidents and injuries, the occurrence of which leads to physical and psychological problems for employees. Accident control is an important factor in reducing risks; Ensuring the health of staff and patients and efforts to prevent occupational accidents, especially in clinical settings. This study was conducted to investigate occupational accidents in three hospitals of Yazd.
Materials and Methods: This is a descriptive-analytical cross-sectional study that was conducted in three teaching hospitals in Yazd. A total of 186 non-physicians from different wards of these three hospitals were included in the study by simple stratified random sampling. Data collection was performed using an 18-item occupational accident questionnaire. Data analysis was performed using SPSS21 software using descriptive statistics and Mann-Whitney and Kruskal-Wallis statistical tests.
Results: Among understudy accidents, exposure to blood or body fluids showed the highest frequency while falling had the lowest frequency. The results showed that there was no relationship between gender and the number and type of accidents, but in some of the accidents, there was a significant relationship between the number and type of accidents, workplace, work experiences, educational level, shift work, and hospital type (p<0.05).
Conclusion: Because these accidents occurred at least once in each of the three selected hospitals, it is necessary to prevent these accidents. Regarding the complex nature of hospital accidents and prevention of incidents, management of hospital accidents and prevention of accidents, requires the determination of all staff and management of the hospital organization.
Investigating the effect of participatory ergonomics implementation on job satisfaction in the staff of Shahid Rajaei Faridan Hospital
Authors: Halvani GH , Fallah H , Fallahzadeh H , Mirzaei Y 
Published: September 2021

Introduction: Participatory ergonomics means the participation of all components of an organization in the development and implementation of ergonomic knowledge, to optimize the working environment with the full support of the senior manager of the organization. Use it to solve problems in your work environment. This study aimed to investigate the effect of participatory ergonomics implementation on job satisfaction in the staff of Shahid Rajaei Hospital in Frieden.
Materials and Methods: The present study was performed as an intervention, before and after, and in Shahid Rajaei Frieden Hospital. The data collection method was through a job spectrum questionnaire. Data analysis was performed using SPSS25 software and paired t-test.
Results: The results showed, the highest job satisfaction is related to rewards and the lowest is related to ancillary benefits. The average scores obtained from the completed questionnaire before and after the intervention were 123 and 135, respectively and a significant relationship between participatory ergonomics implementation and job satisfaction was seen (P <0.03).
Conclusion: In this study, participatory ergonomics was used to improve the ergonomic aspects. The results of this study showed that participatory ergonomics can increase job satisfaction among employees So that there was a significant relationship between the implementation of participatory ergonomics and job satisfaction.