bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the relationship between anhedonia symptoms and trait positive appraisal style in adolescents: A longitudinal survey study
Authors: Yilmaz Merve , Psychogiou Lamprini , Ford Tamsin , Dunn Barnaby D. 
Published: July 2021

ABSTRACTIntroductionAnhedonia, defined as a loss of interest and pleasure in previously enjoyable activities, is a core symptom of depression that predicts a poor treatment response in adolescents. We know little about the cognitive vulnerability factors that contribute to the development of anhedonia in youth. This cross‐sectional and longitudinal survey study investigated the link between anhedonia symptoms and cognitive appraisal of positive affect.MethodsBaseline data were collected from 392 secondary school students in the UK (aged 13–16, 54 % Female), 170 of whom went on to complete the three‐month follow‐up assessment (a 43 % response rate). Participants rated their anhedonia symptoms and appraisal styles which were measured in terms of use of amplifying appraisals, dampening appraisals, and fear of positive emotion.ResultsAt baseline, greater anhedonia was significantly associated with increased levels of dampening and reduced levels of amplifying but was not significantly related to fear of positive emotion. Prospectively, greater baseline levels of amplifying uniquely predicted lower anhedonia severity at three‐month follow‐up, and vice‐versa. There was no evidence for reciprocal prospective associations between anhedonia and, appraisal styles of dampening and fear of positive emotion.ConclusionThese results indicate that cognitive appraisal of positive affect is associated with concurrent and to some extent can predict future symptoms of anhedonia in youth.
Advanced Grid Model of Weighted Mean Temperature Based on Feedforward Neural Network Over China
Authors: Zhu Mingchen , Hu Wusheng , Sun Wei 
Published: July 2021

AbstractWeighted mean temperature (Tm) is a key parameter in Global Navigation Satellite System meteorology. In this study, European Centre for Medium‐Range Weather Forecasts Re‐Analysis product with a spatial resolution of 0.5° × 0.5° from 1999 to 2018 was used to study the spatiotemporal behaviors of Tm in China. Decomposed by Fast Fourier Transformation, Tm and lapse rate (β) variations are highly latitude‐dependent and exhibit periodicities on annual, semi‐annual, and diurnal scales. Meanwhile, Tm keeps increasing at a rate of 0.25 K per decade across China. Based on these discoveries, this study build a new grid Tm model based on feedforward neural network (FNN) with a spatial resolution of 0.5° × 0.5°, known as Grid‐FNN model. FNN is applied to each grid point to compensate the residual error of the corresponding periodic functions. And the fitting accuracy at each grid is improved by the FNN algorithm. ERA‐Interim product with a spatial resolution of 0.4° × 0.4° and Radiosonde data in 2018 are used to validate the new model, and the accuracy of Grid‐FNN model is proved 8.6% and 10.9% better than GPT2w‐Tm model, respectively. The Grid‐FNN model also shows better performance than IGPT2w, GTm‐III, and GTrop model in autumn and winter and in high‐altitude regions.
The Spatial Characteristics of Hourly Rainfall Induced by Tropical Cyclones Along the South China Coast
Authors: Ali Riaz , Li Qinglan , Chen Ji , Huang Dian , Lu Xiaoxiong 
Published: July 2021

AbstractAccurate prediction of tropical cyclone (TC) induced rainfall is of great importance to disaster prevention but quite challenging to operational forecasters. This study quantifies the spatial characteristics of the hourly rainfall caused by TCs at several individual weather stations over the south China coast. We use the historical TC datasets from 2004 to 2018 and the hourly rainfall data from six weather stations to investigate the stations' rainfall distribution characteristics induced by TCs within a distance of 700 km to the weather stations. The hourly rainfall data during the study period from six coastal stations: Zhuzilin (ZZL), Shekou Ferry Terminal (SFT), and Wutong Village (WTV) in Shenzhen, and Hong Kong Observatory (HKO), Sha Tin (SHA), and Tai Mo Shan (TMS) in Hong Kong are used to investigate the statistical relationship. Results show that the most hazardous areas for TC‐induced rainfall are TCs within a distance of 200 km relative to the stations. High intensity TCs in the southwest quadrant may bring torrential rainfall to stations within 500 km distance, and low intensity TCs are likely to induce torrential rainfall to stations within 300 km distance when they are in the northeast and northwest quadrants. If TCs are over the region with the azimuth of 60–150° and distance out of 200 km to the six stations, there is almost no rainfall influence on those stations. The findings of this study are valuable to provide information for the local operational forecasters when predicting the potential rainfall along the south China coast due to future TCs.
Exhumation of the Coastal Metamorphic Belt Above the Subduction‐to‐Transform Transition, in the Southeast Caribbean Plate Corner
Authors: Arkle Jeanette C. , Weber John , Enkelmann Eva , Owen Lewis A. , Govers Rob , Jess Scott , Denison Chris , O'Sullivan Paul B. , Donelick Raymond A. 
Published: July 2021

AbstractPlate corners that transition from subduction to transform motion can result in complex deformation. The southeastern corner of the Caribbean plate is a site where active westward subduction of the oceanic South American plate transitions to transform motion along continental South America. The Northern Range (Trinidad) and Paria (Venezuela) metamorphic mountains are located directly above this eastward propagating plate transition zone. We examined the exhumation history of the Northern Range and eastern Paria using apatite fission track (AFT) and apatite and zircon (U‐Th)/He (AHe and ZHe, respectively) thermochronology on 21 bedrock samples. These samples yield ages of ∼43–6 Ma (ZHe: aliquots), ∼20–4 Ma (AFT: pooled) and ∼5–2 Ma (AHe: aliquots). Along strike of the mountains, our new and published samples show a gradual eastward increase in age. Thermal modeling reveals two phases of rapid cooling and inferred exhumation that post‐dates oblique collision and that migrated from west to east. We record an ∼six‐fold increase in cooling and exhumation between ∼13–9 Ma in the Paria Peninsula and western Northern Range; a deceleration followed this rapid exhumation at ∼7 and 5 Ma. Synchronous with the deceleration in the west, exhumation of the eastern Northern Range increased ∼4 Ma. These post‐collisional changes in exhumation constrain the inversion to east‐side‐up tilting of the Northern Range to ∼4 Ma. We interpret the timing and pattern of exhumation since the mid‐Miocene to be consistent with the time‐transgressive processes produced by an eastward propagating lithospheric subduction‐transform edge propagator fault.
Estimation of the Slip Rate Along the Unruptured Fault Segment of the M7.2 1896 Rikuu Earthquake, Northeast Japan
Authors: Arora Shreya , Kondo Hisao , Kurosawa Hideki , Koshika Kouta 
Published: July 2021

AbstractThe Ou Backbone Range (OBR) is one of the most seismically active intraplate regions in northeast Japan. Over the past 200 years, it has been the locus of five large magnitude earthquakes, including the M7.2 1896 Rikuu earthquake, which produced coseismic surface deformation along the northern segment of the Eastern Margin Fault Zone of Yokote Basin (EFZYB), while the southern segment remained unruptured. Despite the extensive paleoseismic investigations along the ruptured segment, the slip rate estimates, and the recurrence interval remained largely unresolved along the southern unruptured segment. This study reports the long‐term slip rate, and recurrence interval along the Higashi Chokai san Fault and the signatures of active faulting along the Kanazawa and Omoriyama Faults. Based on the seismic reflection and borehole survey, we have estimated a vertical displacement of 29.3–36.1 m across the Higashi Chokai san Fault, a long‐term slip rate of 1.6–1.9 mm/yr over the past 35 ka, and a recurrence interval of about 3,800–4,600 years.Combining our results with the already published data along the OBR, revealed two seismic gaps, first along the western margin of the OBR, along the partial rupture zone of the 1970 Akita‐ken earthquake, and second, along the eastern margin of the OBR, north of the 2008 Iwate‐Miyagi Nairiku earthquake (IMEQ) rupture zone. Given most of the slip is released elastically, we propose that these seismic gaps have a potential to produce earthquakes with magnitudes Mw7.1 and Mw7.3, respectively if they were to rupture in a single event.
Buried Aseismic Slip and Off‐Fault Deformation on the Southernmost San Andreas Fault Triggered by the 2010 El Mayor Cucapah Earthquake Revealed by UAVSAR
Authors: Parker Jay , Donnellan Andrea , Bilham Roger , Ludwig Lisa Grant , Wang Jun , Pierce Marlon , Mowery Nicholas , Jänecke Susanne 
Published: July 2021

AbstractWe use UAVSAR interferograms to characterize fault slip, triggered by the Mw 7.2 El Mayor‐Cucapah earthquake on the 1 San Andreas Fault in the Coachella Valley providing comprehensive maps of short‐term geodetic surface deformation that complement in situ measurements. Creepmeters and geological mapping of fault offsets on Durmid Hill recorded 4 and 8 mm of average triggered slip respectively on the fault, in contrast to radar views that reveal significant off‐fault dextral deformation averaging 20 mm. Unlike slip in previous triggered slip events on the southernmost San Andreas fault, dextral shear in 2010 is not confined to transpressional hills in the Coachella valley. Edge detection and gradient estimation applied to the 50‐m‐sampled interferogram data identify the location (to 20 m) and local strike (to <4°) of secondary surface ruptures. Transverse curve fitting applied to these local detections provides local estimates of the radar‐projected dextral slip and a parameter indicating the transverse width of the slip, which we equate with the depth of subsurface shear. These estimates are partially validated by fault‐transverse interferogram profiles generated using the GeoGateway UAVSAR tool, and appear consistent for radar‐projected slip greater than about 5 mm. An unexpected finding is that creep and triggered slip on the San Andreas fault terminate in the shallow subsurface below a surface shear zone that resists the simple expression of aseismic fault slip. We introduce the notion of a surface locking depth above which fault slip is manifest as distributed shear, and evaluate its depth as 6–27 m.
Prompt Penetration and Substorm Effects Over Jicamarca During the September 2017 Geomagnetic Storm
Authors: Fejer B. G. , Navarro L. A. , Sazykin S. , Newheart A. , Milla M. A. , Condor P. 
Published: July 2021

AbstractWe used reanalyzed Jicamarca radar measurements to study the response of equatorial ionospheric electrodynamics and spread F during the main phase of the large September 2017 geomagnetic storm. Our observations near dusk on 7 September show very large upward drifts followed by a large short‐lived downward drift perturbation that completely suppressed the lower F region plasma irregularities and severely decreased the backscattered power from the higher altitude spread F. We suggest that this large short‐lived westward electric field perturbation is most likely of magnetospheric origin and is due to a sudden and very strong magnetic field reconfiguration. Later in the early night period, data indicate large, mostly upward, drift perturbations generally consistent with standard undershielding and overshielding electric field effects, but with amplitudes significantly larger than expected. Our analysis suggests that occurrence of storm‐time substorms is one of the major factors causing the large nighttime westward and eastward electric field perturbations observed at Jicamarca near the storm main phase. Our analysis also suggests that magnetospheric substorms play far more important roles on the electrodynamics of the equatorial nighttime ionosphere than has generally been thought.
Alteration‐Induced Volcano Instability at La Soufrière de Guadeloupe (Eastern Caribbean)
Authors: Heap Michael J. , Baumann Tobias S. , Rosas‐Carbajal Marina , Komorowski Jean‐Christophe , Gilg H. Albert , Villeneuve Marlène , Moretti Roberto , Baud Patrick , Carbillet Lucille , Harnett Claire , Reuschlé Thierry 
Published: July 2021

AbstractVolcanoes are unstable structures that deform laterally and frequently experience mass wasting events. Hydrothermal alteration is often invoked as a mechanism that contributes significantly to volcano instability. We present a study that combines laboratory experiments, geophysical data, and large‐scale numerical modeling to better understand the influence of alteration on volcano stability, using La Soufrière de Guadeloupe (Eastern Caribbean) as a case study. Laboratory experiments on variably altered (advanced argillic alteration) blocks show that uniaxial compressive strength, Young's modulus, and cohesion decrease as a function of increasing alteration, but that the internal friction angle does not change systematically. Simplified volcano cross sections were prepared (a homogenous volcano, a volcano containing the alteration zone identified by a recent electrical survey, and a volcano with an artificially enlarged area of alteration) and mechanical properties were assigned to zones corresponding to unaltered and altered rock. Numerical modeling performed on these cross sections, using a hydro‐thermo‐mechanical modeling code, show (a) the importance of using upscaled values in large‐scale models and (b) that alteration significantly increases volcano deformation and collapse volume. Finally, we combined published muon tomography data with our laboratory data to create a 3D strength map, exposing a low‐strength zone beneath the southern flank of the volcano coincident with the hydrothermal system. We conclude that hydrothermal alteration decreases volcano stability and thus expedites volcano spreading and increases the likelihood of mass wasting events and associated volcanic hazards. Hydrothermal alteration, and its evolution, should therefore be monitored at active volcanoes worldwide.
Potential Impact of Photoinhibition on Microphytobenthic Primary Production on a Large Intertidal Mudflat
Authors: Savelli Raphaël , Serôdio João , Cugier Philippe , Méléder Vona , Polsenaere Pierre , Dupuy Christine , Le Fouest Vincent 
Published: July 2021

AbstractMicrophytobenthos (MPB) are a key primary producer of intertidal mudflats. MPB face strong variability in incident irradiance during low tides. Despite photoprotection and photoacclimation, such variations can translate into the photoinhibition of MPB cells. This study explores the effect of photoinhibition on MPB primary production (PP) over a large and productive temperate mudflat (Brouage mudflat, NW France). We used a regional and high‐resolution tri‐dimensional hydrodynamic model coupled to an MPB model with or without photoinhibition. Photoinhibition leads to a 20% (−0.79 × t C) decrease of the simulated MPB PP over the entire mudflat. As the upper shore is exposed to light more frequently and longer than the lower shore, the decrease of MPB PP is higher on the upper shore (−29%) than on the lower shore (−5%). With the highest photosynthetically active radiation cumulated over the mudflat, the decrease of MPB PP due to photoinhibition is the highest during spring and spring tides (−22% and −23%, respectively). The model suggests MPB photoinhibition is sensitive to the photoacclimation status of MPB cells through the light saturation parameter. This first modeling attempt to account for MPB photoinhibition is highly constrained by our current theoretical knowledge and limitations on the MPB growth physiology, but it suggests that this process can have a substantial impact on the MPB PP. As such, assessing the MPB photosynthetic response to the highly variable environmental conditions that prevail in large and productive intertidal mudflats is a real challenge for quantifying MPB PP from a synoptic to inter‐annual time scale.
AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms
Authors: Rejeski Kai , Duque-Afonso Jesús , Lübbert Michael 
Published: July 2021

AbstractThe chromosomal translocation t(8;21) and the resulting oncofusion gene AML1/ETO have long served as a prototypical genetic lesion to model and understand leukemogenesis. In this review, we describe the wide-ranging role of AML1/ETO in AML leukemogenesis, with a particular focus on the aberrant epigenetic regulation of gene transcription driven by this AML-defining mutation. We begin by analyzing how structural changes secondary to distinct genomic breakpoints and splice changes, as well as posttranscriptional modifications, influence AML1/ETO protein function. Next, we characterize how AML1/ETO recruits chromatin-modifying enzymes to target genes and how the oncofusion protein alters chromatin marks, transcription factor binding, and gene expression. We explore the specific impact of these global changes in the epigenetic network facilitated by the AML1/ETO oncofusion on cellular processes and leukemic growth. Furthermore, we define the genetic landscape of AML1/ETO-positive AML, presenting the current literature concerning the incidence of cooperating mutations in genes such as KIT, FLT3, and NRAS. Finally, we outline how alterations in transcriptional regulation patterns create potential vulnerabilities that may be exploited by epigenetically active agents and other therapeutics.
Integrating plant-to-plant communication and rhizosphere microbial dynamics: ecological and evolutionary implications and a call for experimental rigor
Authors: Howard Mia M , Bass Ethan , Chautá Alexander , Mutyambai Daniel , Kessler André 
Published: July 2021

Abstract
The perception of airborne chemical signals by plants can trigger reconfigurations of their metabolism that alter their biotic interactions. While plant-to-plant chemical communication has primarily been studied in the context of eliciting defenses to herbivores and pathogens, recent work suggests that it can also affect plants’ interactions with their rhizosphere microbiomes. In this perspective, we discuss the potential for integrating the fields of plant-to-plant communication and microbial ecology to understand the chemical ecology of plant−microbiome interactions. As an introduction for microbial ecologists, we highlight mechanistic knowledge gaps in plant volatile organic compound (VOC) perception and provide recommendations for avoiding common experimental errors that have plagued the plant communication field. Lastly, we discuss potential implications of plant VOCs structuring rhizosphere microbiomes, particularly effects on plant community and evolutionary dynamics. As we continue to discover links between plant metabolism and their microbiomes—from molecular to community scales—we hope that this perspective will provide both motivation and words of caution for researchers working at the intersection of these two fields.
Herpes simplex virus, early neuroimaging markers and incidence of Alzheimer’s disease
Authors: Linard Morgane , Baillet Marion , Letenneur Luc , Garrigue Isabelle , Catheline Gwenaëlle , Dartigues Jean-François , Peres Karine , Helmer Catherine 
Published: July 2021

AbstractWhile previous studies suggest the implication of herpes simplex virus (HSV) in the onset of Alzheimer’s disease (AD), no study has investigated its association with early neuroimaging markers of AD. In the Three-City and the AMI cohorts, the associations between HSV infection and (i) hippocampal volume (n = 349), (ii) white matter alterations in the parahippocampal cingulum and fornix using diffusion tensor imaging (n = 260), and (iii) incidence of AD (n = 1599) were assessed according to APOE4 status. Regardless of APOE4 status, infected subjects presented (i) significantly more microstructural alterations of the parahippocampal cingulum and fornix, (ii) lower hippocampal volumes only when their anti-HSV IgG level was in the highest tercile—reflecting possibly more frequent reactivations of the virus (p = 0.03 for subjects with a high anti-HSV IgG level while there was no association for all infected subjects, p = 0.19), and (iii) had no increased risk of developing AD. Nevertheless, among APOE4 carriers, infected subjects presented lower hippocampal volumes, although not significant (p = 0.09), and a two or three times higher risk of developing AD (adjusted Hazard ratio (aHR) = 2.72 [1.07–6.91] p = 0.04 for infected subjects and aHR = 3.87 [1.45–10.28] p = 0.007 for infected subjects with an anti-HSV IgG level in the highest tercile) while no association was found among APOE4 noncarriers. Our findings support an association between HSV infection and AD and a potential interaction between HSV status and APOE4. This reinforces the need to further investigate the infectious hypothesis of AD, especially the associated susceptibility factors and the possibility of preventive treatments.
High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells
Authors: Jia Ruochen , Kutzner Leon , Koren Anna , Runggatscher Kathrin , Májek Peter , Müller André C. , Schuster Michael , Bock Christoph , Loizou Joanna I. , Kubicek Stefan , Kralovics Robert 
Published: July 2021

AbstractMutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for small molecules that selectively inhibit the growth of CALR mutated cells using high-throughput drug screening. We investigated 89 172 compounds using isogenic cell lines carrying CALR mutations and identified synthetic lethality with compounds targeting the ATR-CHK1 pathway. The selective inhibitory effect of these compounds was validated in a co-culture assay of CALR mutated and wild-type cells. Of the tested compounds, CHK1 inhibitors potently depleted CALR mutated cells, allowing wild-type cell dominance in the co-culture over time. Neither CALR deficient cells nor JAK2V617F mutated cells showed hypersensitivity to ATR-CHK1 inhibition, thus suggesting specificity for the oncogenic activation by the mutant CALR. CHK1 inhibitors induced replication stress in CALR mutated cells revealed by elevated pan-nuclear staining for γH2AX and hyperphosphorylation of RPA2. This was accompanied by S-phase cell cycle arrest due to incomplete DNA replication. Transcriptomic and phosphoproteomic analyses revealed a replication stress signature caused by oncogenic CALR, suggesting an intrinsic vulnerability to CHK1 perturbation. This study reveals the ATR-CHK1 pathway as a potential therapeutic target in CALR mutated hematopoietic cells.