bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Value of Using Patient-Oriented MRI Reports in Clinical Practice
Authors: Perlis Nathan , Finelli Antonio , Lovas Mike , Lund Alexis , Meo Amelia Di , Lajkosz Katherine , Berlin Alejandro , Papadakos Janet , Ghai Sangeet , Deniffel Dominik , Meng Eric , Wiljer David , Alibhai Shabbir , Bakas Vasiliki , Badzynski Adam , Lee Odelia , Cafazzo Joseph , Haider Masoom 
Published: December 2021

Abstract
Purpose

Standard radiology reports (SRR) are designed to communicate information between doctors. With many patients having instantaneous access to SRRs on patient portals, interpretation without guidance from doctors can cause anxiety and panic. We designed a patient-centred prostate MRI template report (PACERR) to address some of these challenges and tested whether PACERRs improve patient knowledge and experience.
Materials and Methods

Patients booked for clinical prostate MRI were randomly assigned to SRR or SRR + PACERR. Questionnaires included multiple-choice that targeted 4 domains (understanding, usefulness, next steps, emotional experience) hypothesized to improve with patient-centred reports and short answer questions, testing knowledge regarding MRI results. Clinical encounters were observed and recorded to explore whether adding PACERR improved communication. Likert scaled-responses and short-answer questions were compared using Mann-Whitney U test and Kruskal-Wallis test.
Results

Of the 40 participants, the majority were MRI naïve (70%). Patients receiving a PACERR had higher scores in the categories of patient understanding (mean: 4.17 vs. 3.39, p=0.006), usefulness (mean: 4.58 vs. 3.07, p<0.001), and identifying next steps (mean: 1.89 vs. 3.03, p=0.003) but not emotional experience (mean: 4.18 vs. 3.79, p=0.22). PACERR participants found the layout and design more patient friendly (mean: 4.47 vs. 2.61, p<0.001) and easier to understand (mean: 4.37 vs. 2.38, p<0.001). In the knowledge section, overall, the PACERR arm scored better (87% vs. 56%, p=0.004).
Conclusion

With the addition of Prostate MRI PACERR, participants had better understanding of their results and felt more prepared to involve themselves in discussions with their doctor.
Clinical Features and Ultrasound Findings of a Rare Musculoskeletal System Disease--neuromuscular Choristomas
Authors: Guo Wen , Wang Hong , Chen Tao , Yang Wei , Wang Shu-Feng , Chen Shan-Lin 
Published: December 2021

Abstract
Background: Neuromuscular choristomas (NMCs) as exquisitely rare developmental lesions have previously been established associated with recurrent fibromatosis after surgery, led to multiple operations, or even amputation. Yet, the report about ultrasound imaging features and clinical conditions of NMCs was rare. The purpose of this study was to describe the ultrasound features and clinical analysis of NMCs to provide suggestions to the optimal management strategy.Methods: From 2020 September to 2021 September, 7 patients with a confirmed diagnosis of NMC who underwent ultrasound examination in our department were enrolled into our study. Physical examinations were performed to detect motor deficit, sensory deficit, neuropathic pain, limb undergrowth, muscular atrophy, cavus foot and bone dysplasia. Ultrasound imaging were performed and investigated in both involved nerve and neuromuscular choristomas associated desmoid-type fibromatosis (NMC-DTF). All patients had a definite history and regular follow up. The clinical course, physical examinations, ultrasound features and pathologic results of NMC patients were analyzed.Results: Seven patients with an average age of 7.0±7.2 years (range: 2-22 years) were enrolled into our study. Nerves involved included the sciatic nerve (6 cases) and the brachial plexus (1 case). 6 patients (85.7%) presented with manifestations of limb undergrowth, 6 (85.7%) with muscular atrophy, and 5 (71.4%) with cavus foot deformity. Based upon ultrasound findings, all visible involved nerve segments presented with hypoechoic and fusiform enlargement with intraneural skeletal muscle elements. Five patients (71.4%) had NMC-DTFs at the site of the affected nerve. All NMC-DTFs were shown as hypoechoic solid lesion adjacent to the nerve and well-circumscribed. In the subset of surgery group, all 5 patients presented with progression to NMC-DTFs at the site of the NMCs. No fibromatosis was detected in the other two non-surgery patients. Conclusions: Understanding of the typical ultrasound features and clinical associated conditions would help to early diagnose the rare disease. When a potential diagnosis is made, invasive procedure like biopsy or resection might be not a good choice given frequent complication by aggressive recurrence.
Public Attitudes Towards Sharing Loyalty Card Data for Academic Health Research: a Qualitative Study
Authors: Dolan Elizabeth H , Shiells Kate , Goulding James , Skatova Anya 
Published: December 2021

Abstract
Background: A growing number of studies show the potential of loyalty card data for use in health research. However, research into public perceptions of using this data is limited. This study aimed to investigate public attitudes towards donating loyalty card data for academic health research, and the safeguards the public would want to see implemented. The way in which participant attitudes varied according to whether loyalty card data would be used for either cancer or COVID-19 research was also examined. Methods: Participants (N=40) were recruited via Prolific Academic to take part in semi-structured telephone interviews, with questions focused on data sharing related to either COVID-19 or ovarian/bowel cancer as the proposed health condition to be researched. Content analysis was used to identify sub-themes corresponding to the two a priori themes, attitudes and safeguards.Results: Participant attitudes were found to fall into two categories, either rational or emotional. Under rational, most participants were in favour of sharing loyalty card data. Support of health research was seen as an important reason to donate such data, with loyalty card logs being considered as already within the public domain. With increased understanding of research purpose, participants expressed higher willingness to donate data. Within the emotional category, participants shared fears about revealing location information and of third parties obtaining their data. With regards to safeguards, participants described the importance of anonymisation and the level of data detail; the control, convenience and choice they desired in sharing data; and the need for transparency and data security. The change in hypothetical purpose of the data sharing, from Covid-19 to cancer research, had no impact on participants’ decision to donate, although did affect their understanding of how loyalty card data could be used. Conclusions: Based on interviews with the public, this study contributes recommendations for those researchers and the wider policy community seeking to obtain loyalty card data for health research. Whilst participants were largely in favour of donating loyalty card data for academic health research, information, choice and appropriate safeguards are all exposed as prerequisites upon which decisions are made.
The Impact of COVID-19 on Individual Oral Health: A Protocol for a Systematic Scoping Review
Authors: Dickson-Swift Virginia , Knevel Ron , Kangutkar Teejeshere 
Published: December 2021

Abstract
Poor oral health continues to be one of the most prevalent non-communicable diseases (NCDs) worldwide consuming one-fifth of out-of-pocket health expenditure [1-3]. In 2017, it was estimated that oral diseases affect close to 3.5 billion people worldwide, with caries (dental decay) of permanent teeth being the most common condition [4]. It is estimated that 44% of all people worldwide are suffering from untreated caries in primary and permanent teeth [5]. International data indicates that dental caries is one of the most prevalent health conditions [6-8] and a leading cause of preventable hospitalization [6]. Poor oral health is also associated with a number of other chronic diseases including stroke and cardiovascular disease [9, 10]. People’s ability to look after their oral health is impacted by a range of social, economic, environmental and political determinants [11] and the impact of COVID-19 on oral health is hypothesised to be significant.
Nitrogen Application Practices to Reduce Cd Concentration in Rice (Oryza Sativa L.) Grains
Authors: Zhou Qingyun , Wang Hui , Xu Chao , Zheng Shen , Wu Meiyan , Zhang Quan , Liao Yulin , Zhu Hanhua , Zhu Qihong , Huang Daoyou 
Published: December 2021

Abstract
Cd pollution in paddy soils creates challenges in rice grain production, thereby threatening food security. The effectiveness of different base-tillering-panicle urea application ratio and the combined basal application of urea and Chinese milk vetch (CMV, Astragalus sinicus L.) in minimizing Cd accumulation in rice grains was explored in a Cd-contaminated acidic soil via a field experiment. The results indicated that under similar N application rates, an appropriate amount of urea applied at the panicle stage or the combined basal application of urea and CMV decreased Cd absorption by rice roots and its accumulation in rice grains, as compared with that of conventional N application (control). Furthermore, under a 3:4:3 base-tillering-panicle urea application ratio or for basal application of CMV at high levels, Cd concentrations in brown rice were significantly lower (40.7% and 34.1%, respectively) than that of control. Cd transport coefficient from root to straw was significantly higher than that of control when an appropriate amount of urea was applied at the panicle stage or urea and CMV were applied basally, whereas the Cd transport coefficient from straw to brown rice was relatively lower. Moreover, soil pH, or the concentrations of CEC and CaCl2-Cd under different N fertilizer treatment was not significantly different. However, rice grain yield increased by 29.4% with basal application of a high amount of CMV compared with that of control. An appropriate amount of urea applied at the panicle stage or the combined basal application of urea and CMV decreased Cd absorption by rice roots and inhibited its transport from straw to brown rice, thus reducing Cd concentration in brown rice. Therefore, combined with the key phase of Cd accumulation in rice, a reasonable urea application ratio or a basal application of high amounts of CMV can effectively reduce Cd concentration in brown rice.
Electrochemical Degradation of Carbamazepine: A Case Study of Quantification of “10, 11 Dihydro-10 Hydroxy Carbamazepine And 10, 11-Epoxycarbamazepine” As The Main By-Products Using LC-TOF/MS.
Authors: Mussa Zainab Haider , Al-Qaim Fouad Fadhil 
Published: December 2021

Abstract
Carbamazepine (CBZ) is one of the most widely used antiepileptic drugs in Malaysia, so, it was detected in wastewater frequently. The electrochemical treatment process has been applied for the degradation of CBZ using graphite-PVC as an anode. However, two main by-products, namely, 10,11-dihydro10-hydroxy carbamazepine (HDX-CBZ) and 10,11-epoxycarbamazepine (EPX-CBZ) have been analysed and quantified using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). HDX-CBZ and EPX-CBZ were analysed in positive ionisation mode and were separated chromatographically using 5 mm, 2 mm´150 mm C18 column at a flow rate of 0.3 mL/min. To improve sensitivity and detectability, SPE was applied as a pre-concentration step for the treated carbamazepine samples to extract and pre-concentrate HDX-CBZ and EPX-CBZ. However, three different solvents, namely, methyl tertiary butyl ether, acetone and methanol, have been optimized to enhance the recovery. The recovery was 85% and 92% for HDX-CBZ and EPX-CBZ, respectively, in the presence of methanol. The limit of quantification (LOQ) was 0.588 and 0.109 µg/L for both by-products, respectively. The concentration of HDX-CBZ and EPX-CBZ was 343 and 144 μg/L, respectively, after 20 min of treatment, then, it was decreased to 17.2 and 9.8 μg/L at 40 min. Finally, both by-products were eliminated after 60 min.
Mass Spectrometry-Based Identification of New Serum Biomarkers in Patients with Latent Infection Pulmonary Tuberculosis
Authors: Li Yan-Xia , Zheng Kang-Di , Duan Yu , Liu Hua-Juan , Tang Yu-Qun , Wu Jun , Lin Dong-Zi , Zhang Zhao 
Published: December 2021

Abstract
Background: To screen specific metabolic markers serum metabolic biomarkers which can achieve the main monitoring indicators to evaluate the development from latent infection to active tuberculosis infection, and analysis its underlying mechanisms and functions. Methods: Four groups of serum, including healthy control, latent infection, drug sensitivity (DS), and drug resistant tuberculosis, were collected. The metabolites in all serum samples were extracted by oscillatory, deproteinization, and then were detected by LC-MS/MS analysis. Normalization by Pareto-scaling method, the difference analysis was carried out by Metaboanalyst 4.0 software, one-way ANOVA analysis among groups showed that p-value ≤0.05 was regarded as a different metabolite. To clarify the dynamic changes and functions of differential metabolites with disease progression, and explore its significance and mechanism as a marker by further cluster analysis, functional enrichment analysis, and relative content change analysis of differential metabolites. Results: There were 565 significantly different metabolites in four groups. Differential metabolites, including Indole-3-acetaldehyde, Theophylline, Inosine and Prostaglandin H2, etc., may be the key serum biomarkers to diagnose the period of latent infection of Mycobacterium tuberculosis (M. tuberculosis). which was closely related to Amino acid metabolism, Biosynthesis of other secondary metabolites, Nucleotide metabolism, Endocrine system, Immune system, Lipid metabolism, and Nervous system. Conclusion: Indole-3-acetaldehyde, Theophylline, Inosine, and Prostaglandin H2, the 4 metabolites may be potential markers diagnosing the period of latent infection of M. tuberculosis. Meanwhile, Inosine and Prostaglandin E1 can become potential biomarkers for the diagnosis of latent infection, and Theophylline and Cotinine 1 can be used as potential markers to monitor disease progression, which established strategy provided promising clinical application prospects for the development of disease assessment by combining small molecule metabolic markers to improve the sensitivity and specificity of disease diagnosis.
The Fast Fixed-Time Bipartite Synchronization of Coupled Delayed Neural Networks with Signed Graphs
Authors: Yang Shiju , Li Chuandong , Li Yu , Yang Ting , Li Bo 
Published: December 2021

Abstract
In this paper, the fixed-time bipartite synchronization problem for coupled delayed neural networks with signed graphs is discussed. Different from traditional neural networks, the interactions between nodes of delayed neural networks can be either collaborative or antagonistic. Furthermore, compared with the initial-condition based finite-time synchronization, the settling time is bounded by a constant within fixedtime regardless of the initial condition. It is worth noting that the fixed-time stable network for bipartite synchronization in this paper achieves more faster convergence than most existing publications. By applying constructing comparison system method, Lyapunov stability theory and inequality techniques, some sufficient criteria for fixed-time bipartite synchronization are obtained. Finally, two numerical examples are granted to display the performance of the obtained results.
Potential Anticarcinogenic Effects From Plasma of Elderly After Exercise Training: A Pilot Study
Authors: Peres Alessandra , Dorneles Gilson , Branchini Gisele , Nunes Fernanda , Romão Pedro , Minuzzi Luciele Guerra , Lira Fabio , Cavalcante Mateus , Elsner Viviane 
Published: December 2021

Abstract
This study aimed to evaluate the impact of exercise training plasma on in vitro prostate cancer cell viability and proliferation. PC3 prostate cancer cells were incubated with plasma obtained from young women with high and low physical fitness (PF) and with the plasma collected from institutionalized elderly before and after multimodal exercise training. Plasma from High PF women induced the lowest cell viability and proliferation after incubation time. PC3 cells presented lower cell viability and diminished rates of cell proliferation after the incubation with post-training plasma samples of elderly. The incubation of PC3 cells with post-training plasma of elderly decreased the mitochondrial membrane polarization and increased mitochondrial reactive oxygen species (ROS) production without changes in cytosolic ROS. Post-training plasma did not change apoptosis or necrosis rates in the PC-3 cell line. Multimodal exercise training increased the plasma levels of IL-2, IL-10, IFN-α, and FGF-1, and decreased TNF-α concentrations in institutionalized elderly. In conclusion, we showed that systemic adaptations in plasma mediators of institutionalized elderly may alter cell viability and proliferation by targeting mitochondrial ROS in a prostate cancer cell line.
Impact of Event Scale-6 (IES-6) for U.S. Adults Who Experienced the COVID-19 Pandemic
Authors: Jeong Jiin , Kim Ah-Ram , Hilton Claudia , Hong Ickpyo 
Published: December 2021

Abstract
Background: Post-traumatic stress disorder (PTSD) is a mental illness caused by traumatic events, such as the COVID-19 pandemic. Accurate diagnosis of this disorder is critical to establish effective intervention approaches. The Impact of Event Scale-6 (IES-6) is widely used for PTSD screening, but there has been no research on its psychometric properties with individuals who experienced the COVID-19 pandemic.Methods: A random sample of 600 participants were randomly selected from a COVID-19 survey database (n = 6,391). Rasch analysis was conducted to examine item fit, rating scale structure, construct validity, differential item functioning (DIF), and precision of the IES-6. Results: The principal component analysis of Rasch residuals (54.1% of the raw variance explained) and the average of residual correlations (average r = .19) supported the unidimensionality structure in the IES-6. The rating scale was suitable, and the item difficulty hierarchy was logical. The item fit and the DIF contrast were acceptable, except for item 5. The IES-6’s person reliability was .76, which was also an acceptable level.Conclusions: This study showed that the IES-6 has acceptable item-level psychometrics for screening PTSD in adults in the United States for individuals who have experienced the COVID-19 pandemic. The findings suggested that the IES-6 would be useful for the rapid identification of PTSD and allow clinicians to quickly provide interventions for people with the disorder and their families.
In Vitro Evaluation of Herbicides on Beneficial and Pathogenic Microorganisms
Authors: Reddy Thumu Venkateswara , Menon Meera V. , K. Anita Cherian , P.V. Sindhu , Mohan Karthika , George Daly 
Published: December 2021

Abstract
An experiment was conducted in the laboratory to evaluate the effect of herbicides on beneficial and pathogenic microorganisms. Eighteen treatments included six herbicides at three different doses viz., cyhalofop-butyl (80, 160 and 240 ppm), cyhalofop-butyl + penoxsulam (150, 300 and 450 ppm), bispyribac-sodium (25, 50 and 75 ppm), fenoxaprop-p-ethyl (60, 12 and 180 ppm), carfentrazone-ethyl (20, 40 and 60 ppm) and chlorimuron-ethyl + metsulfuron-methyl (4, 8 and 12 ppm) evaluated on beneficial microbial bioagents (Trichoderma viride and Pseudomonas fluorescens) and pathogenic microorganisms (Rhizoctonia solani, Pyricularia oryzae and Xanthomonas oryzae pv. oryzae). Results revealed that bispyribac-sodium and cyhalofop-butyl + penoxsulam had greatest inhibitory effect on pathogenic microorganisms Rhizoctonia solani (47.76 and 54.40%) and Pyricularia oryzae (49.07 and 61.12%), but showed no effect on Xanthomonasoryzaepv. oryzae, and were less harmful to biocontrol agents Trichoderma viride and Pseudomonas fluorescens at recommended doses, which were effective in control of broad spectrum of weed flora in rice ecosystem.
Longer Diagnosis-surgery Duration Is Associated With an Increased Risk of Early Postoperative Complications for Crohn's Disease: A Retrospective Study
Authors: Chen Xuanyi , Zhang Siqi , Shen Fanru , Shi Yuan , Liu Sailiang , Jin Yihua , Zhong Ming , Qiao Yuqi , Yu Minhao 
Published: December 2021

Abstract
Background: Early postoperative complications(ePOCs) frequently occur in Crohn’s patients after surgery. The risk factors of ePOCs for Crohn’s disease (CD), however, remain controversial. We aimed to assess the incidence and risk factors of ePOCs in CD patients after surgical resection.Methods: The retrospective study was conducted on 97 patients undergoing surgeries between January 2010 and September 2019 for Crohn’s disease in a tertiary hospital in China. Results: In total, 33 patients (34.0%) experienced ePOCs, including 11 intra-abdominal septic complications (11.3%) and 1 postoperative death (1.0%). Severe complications (Dindo–Clavien III–IV) were seen in 8 patients (8.2%). In multivariate analysis, diagnosis-surgery duration exceeding 6 months(odds-ratio [OR]=4.07; confidence interval [CI] 95%[1.10-15.09], P=0.036), serum platelet count <300*1000/mm3(odds-ratio [OR]=6.74; confidence interval [CI] 95%[1.58-28.71], P=0.01) and serum gamma-glutamyl transpeptidase(GGT) level >10U/L(odds-ratio [OR]=9.22; confidence interval [CI] 95%[1.23-68.99], P=0.031)were identified as independent risk factors for ePOCs. Preoperative exposure to anti-tumor necrosis factor (TNF) agents (P=1.00) were not associated with a higher risk of ePOCs. 34.0% of CD patients developed ePOCs after surgical resection.Conclusions: Diagnosis-surgery duration exceeding 6 months, serum platelet count <300*1000/mm3, and serum GGT level >10U/L were associated with an increased risk of ePOCs. Preoperative exposure to anti-TNF agents were not associated with a higher risk of ePOCs.
Stochastic Model For Setpoint of a Rolling Mill: An Application In The Soybean Oil Production
Authors: Ferreira Magna Paulina de Souza , Arantes Márcio da Silva , Arantes Jesimar da Silva , Bonnard Renan , Toledo Claudio Fabiano Motta 
Published: December 2021

Abstract
A scientific challenge on industrial production is to mathematically represent a production process, and this challenge increases when describing production processes with stochastic behavior. The present paper will be approaching a specific part of the production process of soybean oil, where the main objective is to maximize the oil extraction by keeping the thicknesses of the soybean flakes within an operating range. We propose a method, based on a mathematical stochastic model, to obtain pressure setpoints that produce flakes as ideal as possible for oil extraction. The results reported are achieved by applying the proposed method in the industry with improvements within the process in terms of time and quality.