bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Organic Sprouted Whole Wheat Grain Flourless Bread Decreases DNA Damage in Diabetic Patients?
Authors: Rajkovic Milan , Glavinic Uros , Ristanic Marko , Cosic Milivoje , Dimitrijevic-Sreckovic Vesna , Ilic Iva , Djelic Ninoslav 
Published: September 2021

Abstract
Diabetes is one of the main health concerns, especially in developed countries. During the last few decades, the percentage of diabetic persons is constantly increasing. Although the genetic factors have a strong influence in the development of diabetes, environmental influence (physical inactivity, inadequate nutrition leading to obesity) also have an important impact. The main objective of this investigation was to evaluate the possible influence of organic sprouted whole wheat grain flourless bread Tonus® (product of Trivit, Becej, Serbia) on DNA damage at various stages of progression through type 2 diabetes mellitus (T2DM). In addition to control (non-diabetic) subjects we analyzed obese, pre-diabetic and diabetic patients, for a total of four experimental groups. All subjects used to eat Mediterranean diet for at least two years before being included in our study. In each of four groups we had five persons practicing the Mediterranean diet but instead of bread they consumed flourless bread Tonus®. The DNA damage was evaluated on peripheral blood mononuclear cells by alkaline single cell gel electrophoresis (Comet) assay at the very beginning (before starting the Tonus® bread diet), and after exactly the three months of consumption of Tonus® bread. Statistical analysis revealed that only in patients with type 2 diabetes, Tonus® bread intake led to decreased DNA damage compared to the level of DNA damage of these patients before they started Tonus® bread diet. We assume that decrease of body weight and hyperinsulinemia caused by Tonus® bread in the diet might be one of the main causes of decreased DNA damage.
The Influence of Zinc and Heavy Metals in Feed and Water on the Quality of Cryopreserved Bull Semen
Authors: Jakovljević Goran , Lazarević Miodrag , Mirilović Milorad , Milovanović Aleksandar , Apić Jelena , Šefer Dragan , Nedić Svetlana , Vakanjac Slobodanka 
Published: September 2021

AbstractThis study aimed to assess the influence of different concentrations of zinc (Zn), lead (Pb), mercury (Hg) and cadmium (Cd) found in the feed and water provided to bulls on the concentrations of these metals in cryopreserved bull semen, and to determine their influence onto semen quality parameters. Correlations between heavy metal concentrations in the semen and the quality parameters of semen as estimated by computer-assisted sperm analysis (CASA) and flow cytometry (FC) methods were determined.A total of 40 cryopreserved semen samples originating from bulls housed in 4 different centers for artificial insemination (A, B, C and D) were examined, making a total of 160 samples. The concentrations of metals and semen quality parameters were determined in cryopreserved semen of 10 bulls from each center, namely 4 samples from each bull. Concentrations of Zn, Pb, Hg and Cd in hay and concentrated feed were within the allowed limits as proposed by the National Research Council (NRC, 2000). A strong negative correlation was detected between curvilinear velocity (VCL) and Zn concentrations in the semen (P < 0.01; r = -0.772) in group D, and a positive correlation of VCL with Pb concentrations (P < 0.05 and r = 0.718) in group B. Mercury concentrations in cryopreserved semen correlated negatively to the percent of live sperm cells with intact acrosomes (V/IA: P < 0.05; r = -0.640) and positively with the percent of dead sperm cells with damaged acrosomes (D/DA: P < 0.01; r = 0.766) in group D. This finding confirms the hypothesis that Hg, even at low concentrations, may cause acrosome damage.
Canine Intestinal Lymphangiectasia Concomitant with Renal Cell Carcinoma
Authors: Lee Eun-Joo , Chung Myung-Jin , Jeong Kyu-Shik 
Published: September 2021

Abstract
The etiology of dilation of lymphatic vessels, termed as intestinal lymphangiectasia, remains unknown. In most cases, it occurs secondary to other pathologic conditions such as gastrointestinal neoplasms. However, only a few cases of canine intestinal lymphangiectasia concurrent with non-gastrointestinal neoplasms have been reported so far. Moreover, the correlation between intestinal lymphangiectasia and non-gastrointestinal neoplasms has not been discussed in any other literature. In this study, we report a rare case of intestinal lymphangiectasia concomitant with renal cell carcinoma in an 11 year old female mixed Maltese, suggesting that non-gastrointestinal neoplasms could be associated with the development of intestinal lymphangiectasia. On gross observation, the small intestine was irregularly swollen presenting an accordion like shape. Microscopic examination revealed prominent dilatation of the lymphatic vessels, especially, within the submucosa and muscularis layer. The lacteals within the villi were dilated and presented “club-shaped” tips. The carcinoma might trigger intestinal lymphangiectasia by compressing the main lymphatic vessels or the cisterna chyli, subsequently increasing the pressure of the lymphatic vessels in the gastrointestinal tract. Moreover, metastasis of the carcinoma to the gastrointestinal tract could induce intestinal lymphangiectasia. Thus, the occurrence of intestinal lymphangiectasia must be considered when an abdominal neoplasm is located around major lymphatic vessels.
New psychoactive and classic substances in pooled urine samples collected at the Ultra Europe festival in Split, Croatia
Authors: Sutlović Davorka , Kuret Sendi , Definis Marija 
Published: September 2021

Abstract
We believe that analysing pooled urine samples for recreational drugs used at mass events can provide useful information about trends in drug use. An opportunity arose with the Ultra Europe music festival, which is attended by more than 150,000 people from over 150 countries every year. We analysed 30 pooled urine samples collected from portable chemical toilets located at or close to the Ultra Europe music festival venue in Split, Croatia in 2016–2018 to detect the presence of classic and new psychoactive substances (NPS). Four urine samples collected in 2016 were from a toilet without added chemicals (otherwise used to kill the smell) while the remaining samples were collected from toilets with added chemicals. Samples were qualitatively analysed with gas chromatography-mass spectrometry (GC/MS) using the full-scan mode. Data were compared with the Wiley mass spectral library of designer drugs and our in-house library containing about 1000 compounds and metabolites. We identified forty-six different substances and metabolites, 26 of which were classic substances/metabolites, mostly from the stimulants group, while 20 were NPS. In the NPS group, most of them were phenethylamines and cathinones. The variety of substances was the highest on the first day of the festival regardless of the year, but 2018 showed a significant drop compared to the previous two years. The results of our study revealed a stable trend of classic drug consumption, while NPS trend changed from one year to another.
Work from home and musculoskeletal pain in telecommunications workers during COVID-19 pandemic: a pilot study
Authors: Radulović Azra Huršidić , Žaja Roko , Milošević Milan , Radulović Bojana , Luketić Ivica , Božić Tajana 
Published: September 2021

Abstract
One of the side-effects of the COVID-19 pandemic is a global change in work ergonomic patterns as millions of people replaced their usual work environment with home to limit the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection. The aim of our cross-sectional pilot study was to identify musculoskeletal pain that may have resulted from this change and included 232 telecommunications company workers of both genders [121 (52.2 %) men aged 23–62 (median 41; interquartile range 33–46 yrs.) and 111 (47.8 %) women aged 23–53 (median 40; interquartile range 33–44)] who had been working from home for eight months (from 16 March to 4 December 2020) before they joined the study. The participants were asked to fill in our web-based questionnaire by self-assessing their experience of hand, lower back, and upper back/neck pain while working at home and by describing their work setting and physical activity. Compared to previous work at the office, 90 (39.1 %) participants reported stronger pain in the lower back, 105 (45.7 %) in the upper back/neck, and 63 (27.2 %) in their hands. Only one third did not report any musculoskeletal problems related to work from home. Significantly fewer men than women reported hand, lower back, and upper back/ neck pain (p=0.033, p=0.001 and p=0.013, respectively). Sixty-nine workers (29.9 %) reported to work in a separate room, 75 (32.4 %) worked in a separate section of a room with other household members, whereas 87 (37.7 %) had no separate work space, 30 of whom most often worked in the dining room. Ninety-five participants (40.9 %) had no office desk to work at, and only 75 (32.3 %) used an ergonomic chair. Of those who shared their household with others (N=164), 116 (70.7 %) complained about constant or occasional disturbances. Over a half of all participants (52 %) said that they worked longer hours from home than at work, predominantly women (p=0.05). Only 69 participants (29.9 %) were taking frequent breaks, predominantly older ones (p=0.006). Our findings clearly point to a need to inform home workers how to make more ergonomic use of non-ergonomic equipment, use breaks, and exercise and to inform employers how to better organise working hours to meet the needs of work from home.
Constrains of the Multi-Sectoral Partnerships in Romania - Are Local Action Groups Sustainable?
Authors: Olar Alexandru , Jitea Mugurel-Ionel 
Published: September 2021

Abstract
Local Action Groups (LAGs) are responsible for promoting social and economic development in their territories, by creating local development strategies (LDSs) funded through LEADER Programme. They are area-based multisectoral partnerships, formed from public, private and social stakeholders. The aim of this paper is to study the governance and sustainability of Romanian LAGs, using evidence from the Nord-West Development Region from Romania. Structured interviews with LAGs managers were used as a primary method for collecting data. The results show that LAGs are struggling to remain active during the transition periods between two editions of the program, questioning their capacity to function without LEADER funding. However, they report fewer major changes compared to the last transition, mostly focusing on partnership and territorial structure.
Morphobiometry and Growth Performances of Improved Genetic Types of Chickens (Gallus Gallus) Raised in Cameroon
Authors: Kouatcho Francois Djitie , Radu-Rusu Razvan Mihail , Roşca Dan-Claudiu , Steve Sotche Merveil , Simiz Eliza 
Published: September 2021

Abstract
From July to November 2019, a study has been carried out in the locality of Ngaoundéré in order to contribute to a better knowledge of exotic hens. For this purpose, 190 improved strain chicks of one day-old with an average weight of 35.49±3.78g were distributed according to the type of feather. They were fed an iso-energetic and iso-proteic feed. Data on phenotype characteristics, growth performance, biometric data and carcass were determined. The main results show that three types of feathering were recorded with 16.4% of hens with bare necks and with feathered pits, 78.1% of hens with feathered pits and 5.5% of hens with normal feathers. The majority of hens were recorded with a single comb (75.3%), round mumps (71.2%), white pits (76.4%), black beaks (47.9%) and brown eyes (75.3%). In terms of zootechnical performance, the highest live weight (1758.00±322.20g) was recorded with naked-necked hens and feathered pits. The highest weekly average weight gain was recorded with yellow eyed hens (111.77±16.63g) followed by bare-necked and feathered pits (107.83±20.06g). Hens expressing the Na and Pti genes showed the best growth performance although carcass yield was not significantly affected by feather type. It was concluded that there is a very high phenotypic diversity in the so-called improved hens. However, despite their great potential, responsible management of this genetic resource should be encouraged in order to avoid genetic erosion of local poultry resources.
Ag Continuous Doped SnO2 Sensor Selective to Co2 in Presence of Ethanol at Room Temperature
Authors: Benadjemia M’hammed Benali , Lounis Mourad , Miloudi Mohamed , Beloufa Nabil 
Published: September 2021

Abstract
This paper contains experimental research to minimize the basic limits of the SnO2 semiconductor oxide gas sensor. The operating temperature is high. In addition, their selectivity diminishes with gasses having the same chemical behavior. An experimental methodology is presented to overcome the difficulties of these metal oxides. The efficiency of the gas sensors made of Ag continuously doped at room temperature is excellent. At the end of the testing processes and security measures supplied, laboratory tests and experiments will be conducted to guarantee the acceptability of the planned study.
Science of many names: Onomastic terms in the opinion journalism of the Czech National Corpus
Authors: David Jaroslav , Klemensová Tereza , Místecký Michal 
Published: September 2021

AbstractThe contribution focuses on the use and collocation analysis of basic notions linked to the field of onomastics, including those that are specialized (e.g., “proprium”, “anthroponym”, “toponym”, “chrematonym”, etc.) and the ones that are commonly used (e.g., “proper name/naming”). In the latter case, attention will be paid to whether these terms are connected to onomastic contexts. In general, the research analyses sources where the lemmata are used, including their typical surroundings. The goal of the paper is to show how the public perceives onomastics, whether it is familiar with its key terms. The analysis is based on the data of the Czech National Corpus, version 8, opinion-journalism texts.
Anthroponyms from the pragmatic and communication perspective
Authors: Sokolová Jana 
Published: September 2021

AbstractThe aim of this paper is to extend the model theory and the modeling of onymic signs by V. Blanár by a new pragmatic-communicative dimension. The central motive of the paper is the possibilities and limits of use of personal names in dialogic communication from the perspective of the speaker, and taking into account the addressee who, being a semantic-pragmatic and communication partner/interlocutor of the speaker, receives the locutionary and illocutionary components of discourse, addresses the meaning the speaker attributed to the generated oral discourse, and analyzes the pragmatically charged knowledge that has been transmitted/received during the interaction processes. The author will focus on the functional availability of anthroponyms in the locutionary and non-locutionary intersubjectivity. Both happen on the speaker – addressee axis, with the anthroponyms (i) identifying the speaker and/or (ii) identifying or contacting the addressee in the locutionary intersubjectivity, and indicating another bearer in the non-locutionary intersubjectivity. The identity of the bearer is either confirmed or contradicted by the speaker. Through the using of his/her proper name, the speaker also signals whether or not the bearer of the name belongs to his/her personal sphere. Using concrete language material, the author intends to verify the applicability of anthroponyms with regard to the communication flexibility of the speaker, respect for the rules of cultural partnership in communication and some leeway in the knowledge requirements and expectations toward the addressee, since cooperation and courtesy involving empathy, respect, tactfulness and solidarity are the presumed components of verbal behaviour of both interlocutors.
Lexical-semantic characteristics of the common noun háj (‘grove’) and the proper names Háj in relation to archaeological sites. (The archaeological site and motivation of its name from the aspects of history and linguistics)
Authors: Mitáš Vladimír , Žigo Pavol 
Published: September 2021

Abstract
The article is an attempt to employ the lexical-semantic reconstruction by Professor Vincent Blanár, whose 100th birthday the authors commemorate, to help us understand the cultural legacy of the past. The core of the text is a retrospective view of the names of areas with occurrence of Pre-Slavic material culture and an attempt to identify the motivating lexical units of the oronyms Háj and their derivatives from the territory of today’s Slovakia by means of interconnected knowledge from the fields of linguistics and archaeology. Proper names such as Háj/Háje occurred as late as in Slavic cultural and linguistic environment; however, material evidence at places with such names suggests presence of an older culture, i. e., settlement by population of a different cultural, social or linguistic provenance. In this study, the lexical-semantic reconstruction of the common noun háj in its original meaning as the motivating linguistic unit for oronyms such as Háj and their derivatives is reflected in the mirror of archaeological research. In connection with the sites named Háj/Háje in the regions of Gemer, Malohont, Novohrad or Hont in the south of Central Slovakia, the authors state that from the aspect of archaeology, they are at least remarkable places of the cultural landscape in which we can expect finds from various stages of prehistory and protohistory. The authors also emphasize that in the studied cases, this is not an absolute rule; it is rather a distinct signal of occurrence of archaeological finds.
Development of an effective therapy for alkaptonuria – Lessons for osteoarthritis
Authors: Gallagher James A. , Dillon Jane P. , Ranganath Lakshminarayan R. 
Published: September 2021

Abstract
Osteoarthritis (OA) is one of the major causes of disability and pain worldwide, yet despite a massive international research effort, no effective disease-modifying drugs have been identified to date. In this review, we put forward the proposition that greater focus on rarer forms of OA could lead to a better understanding of the pathogenesis of more common OA. We have investigated the severe osteoarthropathy of the ultra-rare disease alkaptonuria (AKU). In addition to the progress made in finding a treatment for AKU, our research has revealed important lessons for more common OA, including the identification of high-density mineralized protrusions (HDMPs), new pathoanatomical structures which may play an important role in joint destruction and pain in AKU and in OA. AKU is an inherited disorder of tyrosine metabolism, caused by genetic lack of the enzyme homogentisate 1,2 dioxygenase (HGD), which leads to failure to breakdown homogentisic acid (HGA). While most HGA is excreted over time, some of it is deposited as a pigment in connective tissues, a process described as ochronosis. Ochronotic pigment alters the mechanical properties of tissues, leading to inevitable joint destruction and frequently to cardiac valve disease. Until recently, there was no effective therapy for AKU, but preclinical studies demonstrated that upstream inhibition of tyrosine metabolism by nitisinone, a drug previously used in hereditary tyrosinaemia 1 (HT1), completely prevented ochronosis in AKU mice. This was followed by successful clinical trials which have resulted in nitisinone being approved for therapy of AKU by the European Medicines Agency, making AKU the only cause of OA for which there is an effective therapy to date. Study of other rare causes of OA should be a higher priority for researchers and funders to ensure further advances in understanding and eventual therapy of OA.
The role of 14-3-3 η as a biomarker in rheumatoid arthritis
Authors: Abdelhafiz Dima , Kilborn Sally , Bukhari Marwan 
Published: September 2021

AbstractRheumatoid arthritis (RA) is a chronic multisystem inflammatory disorder with significant morbidity and mortality. Making an early diagnosis and providing appropriate treatment decisions based on clinical and other parameter results in good disease control. Biomarkers, such as C reactive protein (CRP), anti-cyclic citrullinated peptides (anti-CCP), and erythrocyte sedimentation rate (ESR), have been traditionally used. Recently novel biomarkers are described. This article reviews the evidence behind a novel biomarker 14-3-3 η that has been found to provide additional diagnostic and prognostic information as well as predicting response to treatment. A systematic literature review is presented showing the evidence behind this molecule.
Оrganizational aspects of primary health care for personal skeleton damage caused by road traffic accidents
Authors: Masljakov V. V. , Pavlova O. N. , Pimenov A. V. , Proshin A. G. , Poljako A. V. , Pimenova A. A. 
Published: September 2021

The purpose of the study. Study the organizational aspects of providing primary health care for victims with the facial department of the skeleton as a result of traffic accidents. Materials and methods. To achieve this goal, a retrospective study was conducted. The work included victims of road accidents with damage to the facial part of the skull between the ages of 18 and 70 years. In total, 150 victims were included in the study between 2000 and 2019. Results of the study and their analysis. The study shows that injuries to the facial skeleton as a result of traffic accidents are relevant. As a result of the study, it was found that as a result of an accident, there is approximately the same number of closed and open injuries. At the same time, open injuries, which could be regarded as medium and severe, were identified in 45 (30%) cases. In addition, data analysis showed that in 30,7% of observations, first aid was provided by random witnesses and/ or relatives of victims who did not have the skills and necessary knowledge to provide such assistance. In addition, an additional 19,3 per cent of first aid was provided by staff of various services who have some knowledge and skills in first aid. This is due to the fact that in the first group, first aid was provided faster than in the second group. The lack of the necessary skills to provide first aid to victims with such an injury can be explained by the rather high percentage of errors, which in the first group amounted to 18,7%, while employees of various services showed good results in providing such assistance and errors were not noted. Key words: primary health care, damage to the facial skeleton, traffic accident.