bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy
Authors: Yang Tianshu , Yang Yunkai , Wang Yan 
Published: May 2021

AbstractEpigenetics studies heritable genomic modifications that occur with the participation of epigenetic modifying enzymes but without alterations of the nucleotide structure. Small-molecule inhibitors of these epigenetic modifying enzymes are known as epigenetic drugs (epi-drugs), which can cause programmed death of tumor cells by affecting the cell cycle, angiogenesis, proliferation, and migration. Epi-drugs include histone methylation inhibitors, histone demethylation inhibitors, histone deacetylation inhibitors, and DNA methylation inhibitors. Currently, epi-drugs undergo extensive development, research, and application. Although epi-drugs have convincing anti-tumor effects, the patient’s sensitivity to epi-drug application is also a fundamental clinical issue. The development and research of biomarkers for epi-drugs provide a promising direction for screening drug-sensitive patients. Here, we review the predictive biomarkers of 12 epi-drugs as well as the progress of combination therapy with chemotherapeutic drugs or immunotherapy. Further, we discuss the improvement in the development of natural ingredients with low toxicity and low side effects as epi-drugs.
Kimura’s disease with recurrent bilateral lacrimal gland involvement in a male Japanese child successfully treated with cyclosporine A
Authors: Sugimoto Keisuke , Enya Takuji , Morimoto Yuichi , Oshima Rina , Miyazaki Kohei , Okada Mitsuru 
Published: May 2021

Abstract
Background
Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, that are typically localized to the neck and head. Involvement of the lacrimal glands and limbs is uncommon and seldom reported.

Case presentation
We report a case of a 4-year-old Japanese boy presenting with bilateral upper eyelid swelling with nodular subcutaneous lesions and peripheral eosinophilia. Based on clinical, histopathological, and laboratory findings, the patient was diagnosed with KD. An itchy subcutaneous mass on the left arm developed at the age of 14 years. Treatment with steroids was effective. However, as the steroids were tapered after the patient developed side effects, the masses relapsed within a few months. Treatment with cyclosporine A was then initiated, which led to an improvement of clinical features and serial levels of cytokines.

Conclusions
We report a rare case of KD with a peculiar clinical presentation. The patient responded well to treatment with cyclosporine A.
Expression levels of plasma exosomal miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p in severe asthma patients and normal individuals with emphasis on inflammatory factors
Authors: Atashbasteh Mostafa , Mortaz Esmaeil , Mahdaviani Seyed Alireza , Jamaati Hamidreza , Allameh Abdolamir 
Published: May 2021

AbstractBackgroundIdentification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNAs in plasma exosomal fractions of severe asthma patients. The expression of miRNAs was determined in relation to the changes in inflammatory markers.MethodSevere asthma patients (n = 30) and healthy subjects (n = 30) were selected among the individuals referred to asthma and allergy clinic. Blood was collected from each participant to determine the serum high-sensitive C-reactive protein (hs-CRP) and total IgE. The exosomal fraction of plasma was isolated and processed for quantitation of miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p expression using quantitative real time-PCR (qRT-PCR).ResultsSerum hs-CRP and total IgE were significantly higher in asthma patients compared to controls. Expression of miR-124, miR-133b, and miR-130a was down-regulated in asthma patients as compared to controls (p < 0.0001). However, the expression of miR-125b was substantially higher in patients compared to controls (p < 0.0001). There was no significant difference in the expression of miR-125b-1-3p in the patients and controls. Data analysis revealed that among the miRNAs, changes in miR-125b in severe asthma patients were highly correlated with the serum levels of hs-CRP and IgE.ConclusionOverexpression of miR-125b in severe asthma which was associated with serum IgE and hs-CRP may suggest that this molecule is linked to inflammatory reactions. Up-regulation of miR-125b together with decreased expression of miR-124, miR-133b, and miR-130a may suggest that this miRNA profile is useful for diagnosis and discrimination of clinical phenotypes of asthma.
The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives
Authors: Li Shulin , Wang Fei , Sun Dong 
Published: May 2021

AbstractChronic kidney disease (CKD) affects 8–16% of the population worldwide and is characterized by fibrotic processes. Understanding the cellular and molecular mechanisms underpinning renal fibrosis is critical to the development of new therapeutics. Microvascular injury is considered an important contributor to renal progressive diseases. Vascular endothelium plays a significant role in responding to physical and chemical signals by generating factors that help maintain normal vascular tone, inhibit leukocyte adhesion and platelet aggregation, and suppress smooth muscle cell proliferation. Loss of the rich capillary network results in endothelial dysfunction, hypoxia, and inflammatory and oxidative effects and further leads to the imbalance of pro- and antiangiogenic factors, endothelial cell apoptosis and endothelial-mesenchymal transition. New techniques, including both invasive and noninvasive techniques, offer multiple methods to observe and monitor renal microcirculation and guide targeted therapeutic strategies. A better understanding of the role of endothelium in CKD will help in the development of effective interventions for renal microcirculation improvement. This review focuses on the role of microvascular injury in CKD, the methods to detect microvessels and the novel treatments to ameliorate renal fibrosis.
Basketball shooting technology based on acceleration sensor fusion motion capture technology
Authors: Zhao Binbin , Liu Shihong 
Published: May 2021

AbstractComputer vision recognition refers to the use of cameras and computers to replace the human eyes with computer vision, such as target recognition, tracking, measurement, and in-depth graphics processing, to process images to make them more suitable for human vision. Aiming at the problem of combining basketball shooting technology with visual recognition motion capture technology, this article mainly introduces the research of basketball shooting technology based on computer vision recognition fusion motion capture technology. This paper proposes that this technology first performs preprocessing operations such as background removal and filtering denoising on the acquired shooting video images to obtain the action characteristics of the characters in the video sequence and then uses the support vector machine (SVM) and the Gaussian mixture model to obtain the characteristics of the objects. Part of the data samples are extracted from the sample set for the learning and training of the model. After the training is completed, the other parts are classified and recognized. The simulation test results of the action database and the real shot video show that the support vector machine (SVM) can more quickly and effectively identify the actions that appear in the shot video, and the average recognition accuracy rate reaches 95.9%, which verifies the application and feasibility of this technology in the recognition of shooting actions is conducive to follow up and improve shooting techniques.
New oscillation theorems for a class of even-order neutral delay differential equations
Authors: Anis Mona , Moaaz Osama 
Published: May 2021

AbstractIn this work, we study the oscillatory behavior of even-order neutral delay differential equations$\upsilon ^{n}(l)+b(l)u(\eta (l))=0$υn(l)+b(l)u(η(l))=0, where$l\geq l_{0}$l≥l0,$n\geq 4$n≥4is an even integer and$\upsilon =u+a ( u\circ \mu ) $υ=u+a(u∘μ). By deducing a new iterative relationship between the solution and the corresponding function, new oscillation criteria are established that improve those reported in (T. Li, Yu.V. Rogovchenko in Appl. Math. Lett. 61:35–41, 2016).
Enhanced carbon acquisition and use efficiency alleviate microbial carbon relative to nitrogen limitation under soil acidification
Authors: Li Tianpeng , Wang Ruzhen , Cai Jiangping , Meng Yani , Wang Zhirui , Feng Xue , Liu Heyong , Turco Ronald F. , Jiang Yong 
Published: May 2021

AbstractBackgroundSoil microbial communities cope with an imbalanced supply of resources by adjusting their element acquisition and utilization strategies. Although soil pH has long been considered an essential driver of microbial growth and community composition, little is known about how soil acidification affects microbial acquisition and utilization of carbon (C) and nitrogen (N). To close the knowledge gap, we simulated soil acidification and created a pH gradient by adding eight levels of elemental sulfur (S) to the soil in a meadow steppe.ResultsWe found that S-induced soil acidification strongly enhanced the ratio of fungi to bacteria (F:B) and microbial biomass C to N (MBC:MBN) and subsequently decreased the C:N imbalance between microbial biomass and their resources. The linear decrease in the C:N imbalance with decreasing soil pH implied a conversion from N limitation to C limitation. To cope with enhanced C versus N limitation, soil microbial communities regulated the relative production of enzymes by increasing the ratio of β-glucosidase (BG, C-acquiring enzyme) to leucine aminopeptidase (LAP, N-acquiring enzyme), even though both enzymatic activities decreased with S addition. Structural equation modeling (SEM) suggested that higher C limitation and C:N-acquiring enzyme stimulated microbial carbon-use efficiency (CUE), which counteracted the negative effect of metal stress (i.e., aluminum and manganese) under soil acidification.ConclusionsOverall, these results highlight the importance of stoichiometric controls in microbial adaption to soil acidification, which may help predict soil microbial responses to future acid deposition.
RETRACTED ARTICLE: Social entrepreneurship and social enterprise phenomenon: toward a collective approach to social innovation in Tunisia
Authors: Fridhi Bechir 
Published: May 2021

AbstractThis article aims to understand the extent to which social entrepreneurship (SE) contributes to the construction of a collective dimension linked to social innovation (SI). We aim to propose new ideas that can deliver insights into the SE phenomenon. This research is also distinct from entrepreneurial ecosystems as its development already requires some successful entrepreneurial action and to do it, the structuring and consolidation of an entrepreneurial ecosystem constitutes a real challenge for the development of SI.This work has been based on a participant observation of eight major events dedicated to social entrepreneurship or the shared economy. In-depth interviews with Tunisian social entrepreneurs were also conducted in order to enrich our corpus. The results show the necessary cooperation of social entrepreneurs for a sustainable and responsible social innovation. Indeed, the analysis emphasizes that the viability and sustainability of a social innovation rests essentially on a collective construction, beyond common social values.
Illegal fishing and compliance management in marine protected areas: a situational approach
Authors: Weekers Damian , Petrossian Gohar , Thiault Lauric 
Published: May 2021

AbstractProtected Areas (PAs) are spatially representative management tools that impose various levels of protection for conservation purposes. As spatially regulated places, ensuring compliance with the rules represents a key element of effective management and positive conservation outcomes. Wildlife crime, and in particular poaching, is a serious global problem that undermines the success of PAs. This study applies a socio-ecological approach to understanding the opportunity structure of illegal recreational fishing (poaching) in no-take zones in Australia’s Great Barrier Reef Marine Park. We use Boosted Regression Trees to predict the spatio-temporal distribution of poaching risk within no-take Marine National Park zones. The results show that five risk factors account for nearly three quarters (73.6%) of the relative importance for poaching in no-take zones and that temporally varying conditions influence risk across space. We discuss these findings through the theoretical lens of Environmental Criminology and suggest that law enforcement strategies focus on reducing the negative outcomes associated with poaching by limiting the opportunity of would-be offenders to undertake illegal activity.
Microbiomes of clownfish and their symbiotic host anemone converge before their first physical contact
Authors: Émie Audet-Gilbert , François-Étienne Sylvain , Sidki Bouslama , Nicolas Derome 
Published: May 2021

AbstractBackgroundOne of the most charismatic, and yet not completely resolved example of mutualistic interaction is the partnership of clownfish and its symbiotic sea anemone. The mechanism explaining this tolerance currently relies on the molecular mimicry of clownfish epithelial mucus, which could serve as camouflage, preventing the anemone's nematocysts' discharge. Resident bacteria are known as key drivers of epithelial mucus chemical signature in vertebrates. A recent study has proposed a restructuration of the skin microbiota in a generalist clown fish when first contacting its symbiotic anemone. We explored a novel hypothesis by testing the effect of remote interaction on epithelial microbiota restructuration in both partners.MethodsWith metataxonomics, we investigated the epithelial microbiota dynamic of 18 pairs of percula clownfish (Amphiprion percula) and their symbiotic anemoneHeteractis magnificain remote interaction, physical interaction and control groups for both partners during a 4-week trial.ResultsThe Physical and Remote Interaction groups’ results evidence gradual epithelial microbiota convergence between both partners when fish and anemone were placed in the same water system. This convergence occurred preceding any physical contact between partners, and was maintained during the 2-week interaction period in both contact groups. After the interaction period, community structure of both fish and anemone’s epthelial community structures maintained the interaction signature 2 weeks after fish–anemone pairs’ separation. Furthermore, the interaction signature persistence was observed both in the Physical and Remote Interaction groups, thus suggesting that water-mediated chemical communication between symbiotic partners was strong enough to shift the skin microbiota durably, even after the separation of fish–anemone pairs. Finally, our results suggest that fish–anemone convergent microbiota restructuration was increasingly associated with the parallel recruitment of threeFlavobacteriaceaestrains closely related to a tyrosinase-producingCellulophaga tyrosinoxydans.ConclusionsOur study shows that bacterial community restructuration, in the acclimation process, does not only rely on direct physical contact. Furthermore, our results challenge, for the first time, the traditional unidirectional chemical camouflage hypothesis, as we argue that convergence of the epithelial microbiota of both partners may play essential roles in establishing mutual acceptance.
Text based personality prediction from multiple social media data sources using pre-trained language model and model averaging
Authors: Christian Hans , Suhartono Derwin , Chowanda Andry , Zamli Kamal Z. 
Published: May 2021

AbstractThe ever-increasing social media users has dramatically contributed to significant growth as far as the volume of online information is concerned. Often, the contents that these users put in social media can give valuable insights on their personalities (e.g., in terms of predicting job satisfaction, specific preferences, as well as the success of professional and romantic relationship) and getting it without the hassle of taking formal personality test. Termed personality prediction, the process involves extracting the digital content into features and mapping it according to a personality model. Owing to its simplicity and proven capability, a well-known personality model, called the big five personality traits, has often been adopted in the literature as the de facto standard for personality assessment. To date, there are many algorithms that can be used to extract embedded contextualized word from textual data for personality prediction system; some of them are based on ensembled model and deep learning. Although useful, existing algorithms such as RNN and LSTM suffers from the following limitations. Firstly, these algorithms take a long time to train the model owing to its sequential inputs. Secondly, these algorithms also lack the ability to capture the true (semantic) meaning of words; therefore, the context is slightly lost. To address these aforementioned limitations, this paper introduces a new prediction using multi model deep learning architecture combined with multiple pre-trained language model such as BERT, RoBERTa, and XLNet as features extraction method on social media data sources. Finally, the system takes the decision based on model averaging to make prediction. Unlike earlier work which adopts a single social media data with open and close vocabulary extraction method, the proposed work uses multiple social media data sources namely Facebook and Twitter and produce a predictive model for each trait using bidirectional context feature combine with extraction method. Our experience with the proposed work has been encouraging as it has outperformed similar existing works in the literature. More precisely, our results achieve a maximum accuracy of 86.2% and 0.912 f1 measure score on the Facebook dataset; 88.5% accuracy and 0.882 f1 measure score on the Twitter dataset.
Feasibility and acceptability of an enhanced cognitive behavioural therapy programme for parent–child dyads with anxiety disorders: a mixed-methods pilot trial protocol
Authors: Galea Samantha , Salvaris Chloe A. , Yap Marie B. H. , Norton Peter J. , Lawrence Katherine A. 
Published: May 2021

Abstract
Background
Cognitive behavioural therapy (CBT) is the most widely recognised and efficacious psychological therapy for the treatment of anxiety disorders in children and adults. However, suboptimal remission rates indicate room for improvement in treatments, particularly when both children and their parents have anxiety disorders. Bidirectional transmission and maintenance of anxiety within parent–child dyads could be better targeted by CBT, to improve treatment outcomes for children and parents with anxiety disorders. This study aimed to develop and evaluate the feasibility and acceptability of a concurrent parent–child enhanced CBT intervention that targets the individual’s anxiety disorder(s), as well as the bidirectional factors that influence and maintain anxiety in the dyad.

Methods
Feasibility and acceptability of the proposed CBT protocol will be evaluated in an open-label pilot trial of the intervention utilising qualitative and quantitative data collection. Ten parent–child dyad participants (n = 20) with anxiety disorders will be recruited for the proposed intervention. The intervention is based on an empirically supported 10-week CBT programme for anxiety disorders in adults, adapted to be delivered to parent–child dyads concurrently, and to target anxious modelling and overprotective behaviours through joint observational exposures. Intervention feasibility will be explored by pre-post symptom change on a range of clinician- and self-report measures to determine preliminary indications of participants’ intervention response and effect size calculations to estimate sample size for a future definitive randomised controlled trial (RCT). Additional feasibility measures will include recruitment rates, completion rates, and adherence to programme requirements. To explore participant acceptability of the intervention, qualitative interviews will be conducted with five parent–child dyads who complete the intervention (n = 10), along with five parent–child dyads with anxiety symptoms who express interest in the intervention (n = 10). Acceptability measures will include prospective and retrospective quantitative self-report and qualitative interview data.

Discussion
This pilot trial will utilise a mixed-methods design to determine the feasibility and acceptability of delivering an enhanced CBT intervention for the concurrent treatment of parent–child dyads with anxiety disorders. The results of this trial will inform the development and implementation of a future definitive randomised clinical trial to evaluate intervention efficacy.

Trial registration
Australian and New Zealand Clinical Trials Registry, ANZCTR1261900033410. Prospectively registered: pre-results. Registered 04 March 2019.
Cisplatin-induced neurotoxicity in cerebellar cortex of male mice involves oxidative stress and histopathology
Authors: Attia Azza , Matta Cecil , ElMazoudy Reda , Khalifa Hanan 
Published: May 2021

Abstract
Background
Despite evidence of neurotoxicity, cisplatin is still considered the most potent drug prescribed in human chemotherapy for a broad spectrum of malignancies. The objective was to evaluate the cerebellar cortex damage including oxidative stress biomarkers and histopathology aspects in male mice. One saline control group and two cisplatin groups were intraperitoneally injected with 0, 5, and 10 mg/kg body weight (bw) cisplatin, twice per week for four successive weeks, respectively.

Results
Cisplatin decreased the body weights of treated mice. Serum levels of superoxide dismutase and glutathione peroxidase were significantly reduced in the 5 and 10 mg/kg dose, twice weekly for 4 weeks treatment; in contrast, there was a significant increase of lipid peroxidation. 5 and 10 mg/kg bw of cisplatin caused histopathological damage in the cerebellum tissue characterized by disruption, disorganization, and degeneration with dense pyknotic nuclei of the granular cells. Ultrastructurally, in the cortical region of the cerebellum, the Purkinje cells showed irregular pyknotic nuclei with indistinct nucleoli, cytoplasmic vacuolation, marked indentation of the nuclear membrane, dilatation of the endoplasmic reticulum, and breakdown and disappearance of mitochondrial cristae. Moreover, the molecular layer showed cellular necrosis and an increased number of lysosomal particles. The myelinated nerve fibers showed degenerative areas distinct by splitting, disruption, and loss of the lamellar pattern of the myelin sheath.

Conclusion
These findings provide a confirmed foresight that the in vivo potential treatment of mice with cisplatin induces cerebellum deficits and impairment in neuronal histology. The identified mechanism which evokes neurotoxicity is oxidative stress-dependent status. This mechanism is pharmacologically boosted by great production of free radical reactive oxygen species.