bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early and mid-term outcomes of nonsurgical management of femoral shaft fractures with associated multiple injuries in school-age children
Authors: Qiao Yi , Wang Xiaodong , Dai Jin , Zhen Yunfang 
Published: May 2021

Abstract
Background

Femoral shaft fractures associated with multiple injuries are commonly encountered in school-age children. Clinical outcomes of non-surgical management of pediatric femoral shaft fractures with high-energy multiple injuries are not well characterized. In this study, we evaluated the early and mid-term clinical outcomes of non-surgical management of pediatric femoral shaft fractures with high energy multiple injuries in our setting.
Methods

Retrospective review of school-age children with femoral shaft fractures managed non-surgically at the orthopedics department over a 3-year period.
Results

Eleven patients (6 boys and five girls; mean age: 7.2 years) with femoral shaft fractures associated with multiple injuries qualified the inclusion criteria. All fractures in this study population were sustained in road traffic accidents. Seven patients recovered very well. Basic functional recovery of lower limbs was satisfactory. Two patients had residual joint dysfunction, 4 patients showed abnormal gait, while 4 patients showed varying degrees of limp because of lower limb length discrepancy.
Conclusion

Clinical outcomes of non-surgical management of pediatric femoral shaft fractures at our center were comparable to the outcomes of other management approaches. Conservative management that shortens the duration of hospital stay without increasing cost of management should be encouraged.
COVID-19 is affecting elderly people more and increasing in its severity
Authors: Mertoglu Cuma , huyut mehmet tahir , olmez hasan , tosun mustafa , kantarci mecit , coban taha abdulkadir 
Published: May 2021

Abstract
Objective

The important changes occur in routine blood tests in Corona Virus Disease 2019 (COVID-19).
Methods

The biochemical, hematological and inflammatory biomarkers of a total of 3969 COVID-19 patients’ results (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn.
Results

In the non-ICU group, lymphocyte to monocyte ratio were lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn and eosinophil, hematocrit, hemoglobin, lymphocyte and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher than the only summer.
Conclusion

The change in routine blood biomarkers in COVID-19 varies in the period from the emergence of the disease until now. Also, the timely change of blood biomarkers was mostly more negative and this indicates that the disease progresses more severely.
Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
Authors: Souza Thiago , Temerozo Jairo , Fintelman-Rodrigues Natalia , Santos Monique Cristina , Hottz Eugênio , Sacramento Carolina , Silva Aline , Mandacaru Samuel , Moraes Emilly Caroline , Trugilho Monique , Gesto João , Ferreira Marcelo , Betoni Felipe , Martins-Gonçalves Remy , Azevedo-Quintanilha Isacláudia , Abrantes Juliana , Righy Cassia , Kurtz Pedro , Jiang Hui , Tan Hongdong , Morel Carlos , Bou-Habib Dumith , Bozza Fernando , Bozza Patricia 
Published: May 2021

Abstract
Critically ill 2019 coronavirus disease patients (COVID-19) under invasive mechanical ventilation (IMV) are 10- to 40-times more likely to die than the general population. Although progression from mild to severe COVID-19 has been associated with hypoxia, uncontrolled inflammation and coagulopathy, the mechanisms involved in progression to severity are poorly understood. By analyzing the virome from tracheal aspirates (TA) of 25 COVID-19 patients under IMV, we found higher levels and differential expression of human endogenous retrovirus K (HERV-K) genes compared to nasopharyngeal swabs from mild cases and TA from non-COVID patients. Proteomic analysis and RT-PCR confirmed the presence of HERV-K in these patients. Moreover, increased HERV-K expression was triggered in human primary monocytes from healthy donors after experimental SARS-CoV-2 infection in vitro. In critically ill patients, higher HERV-K levels were associated with early mortality (within 14 days) in the intensive care unit. Increased HERV-K expression in deceased patients associated with IL-17-related inflammation, monocyte activation and higher consumption of clotting/fibrinolysis factors. Our data implicate the levels of HERV-K transcripts in the outcome of critical COVID-19 patients under invasive mechanical ventilation.
Anisotropic scaling in 3D topological models: fromWeyl semimetal to Hopf insulator
Authors: Rufo S. , Griffith M. A. R. , Lopes Nei , Continentino M. A. 
Published: May 2021

Abstract
A proposal to study topological models beyond the standard topological classification and that exhibit breakdown of Lorentz invariance is presented. The focus of the investigation relies on their anisotropic quantum critical behavior. We study anisotropic effects on three-dimensional (3D) topological models, computing their anisotropic correlation length critical exponent ν obtained from numerical calculations of the penetration length of the zero-energy surface states as a function of the distance to the topological quantum critical point. A generalized Weyl semimetal model with broken time-reversal symmetry is introduced and studied using a modified Dirac equation. An approach to characterize topological surface states in topological insulators when applied to Fermi arcs allows to capture the anisotropic critical exponent θ = νx/νz. We also consider the Hopf insulator model, for which the study of the topological surface states yields unusual values for ν and for the dynamic critical exponent z. From an analysis of the energy dispersions, we propose a scaling relation να¯ zα¯ = 2q and θ = νx/νz = zz/zx for ν and z that only depends on the Hopf insulator Hamiltonian parameters p and q and the axis direction α¯ . An anisotropic quantum hyperscaling relation is also obtained.
Association between prenatal maternal anxiety and/or stress and offspring’s cognitive functioning: a systematic review and meta-analysis
Authors: Delagneau Garance , Testa Renee , Veen Sarit Van , Anderson Peter 
Published: May 2021

Abstract
The relationship between prenatal maternal stress and/or anxiety and children’s cognitive development is inconclusive. This systematic review and meta-analysis aims to examine the relationship between the different domains of stress, anxiety and children’s cognitive outcomes during the first 18 years of life. Five databases were searched for all observational studies investigating the association between symptoms of prenatal maternal anxiety and/or stress and children’s cognitive outcomes. Of 7,004 articles identified, 21 met the inclusion criteria and 11 provided usable data that were further analysed quantitatively. A weak negative association was found between prenatal stress and/or anxiety exposure and the offspring’s language development. Associations varied based on the type of prenatal psychological exposure (i.e., trait anxiety, state anxiety, perceived stress, stress response). Specifically, maternal prenatal exposure to stress but not anxiety was found to correlate with children’s general intellectual skills. Moreover, trait anxiety but not the combined exposure to trait and state anxiety was correlated with attention in the offspring. While exposure to stress and/or anxiety at any stage of pregnancy was found to be associated with adverse cognitive outcomes in the offspring, there was a trend that timing of exposure may be associated with distinct cognitive outcomes. Findings support the need for screening and interventions to prevent or minimise mental health problems in pregnant women in order to optimise child development. Findings also have implications for conceptualising prenatal stress and anxiety in future research, as well as investigating timing and cumulative effects of prenatal stress and/anxiety exposure.
Rifaximin: unique selective antibiotic for the treatment of gastrointestinal diseases
Authors: Plotnikova E. Yu. 
Published: May 2021

The human gut microbiota has been a major focus of scientific research in recent years. Studies based on metagenomic methods have revealed the multifaceted abilities of gut microbes, from metabolic functions to immunomodulation, from antipathogenic activity to behavioral formation. Since the gut microbiota plays a crucial role in maintaining human health, more or less specific changes in the gut microbiota are associated with various gastrointestinal diseases. These data strongly support the use of gut microbiota modulators, such as antibiotics, prebiotics and probiotics, as the choice for almost all gastrointestinal disorders. The traditional use of antibiotics in clinical practice is to counteract local or systemic infections. It can be assumed that antibiotics have a detrimental effect on the intestinal ecology. However, this is not true for all antibiotics.Rifaximin is a non-systemic oral antibiotic derived from rifampin and is characterized by a broad spectrum of antibacterial activity against Gram-positive and negative, aerobic and anaerobic bacteria. Rifaximin was first approved in Italy in 1987 and then in many other countries of the world for the treatment of several gastrointestinal diseases. This review presents the pharmacology and pharmacodynamics of rifaximin, describing various actions beyond its antibacterial activity, such as altering virulence, preventing intestinal mucosal adhesion and bacterial translocation. Key studies on the different uses of rifaximin are also described. In addition, rifaximin has some anti-inflammatory effects with minimal impact on the overall composition of the gut microbiota. All of these properties make rifaximin a good candidate for the treatment of various gastrointestinal diseases.
Periostin as a promising biological marker of early recurrence of polyposis rhinosinusitis after surgical treatment
Authors: Svistushkin V. M. , Chichkova N. V. , Pshonkina D. M. 
Published: May 2021

Introduction. In spite of the numerous studies devoted to the issues of chronic rhinosinusitis with nasal polyps, the urgency of this problem remains due to the high incidence of the disease. The relapsing course of chronic rhinosinusitis with nasal polyps determines the uncontrolled course of bronchial asthma by patients with combined pathology. The main goal of case management of patients with chronic rhinosinusitis with nasal polyps is to achieve control over the polyposis process. It has been shown, that a promising direction is the study of biological markers. Goal. Study of the concentration of serum periostin in combination with serum eosinophilia and the number of eosinophils of the nasal secretion to predict early recurrence of chronic rhinosinusitis with nasal polyps after surgical treatment.Materials and methods. The study included 47 patients with a diagnosis of chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis with nasal polyps in combination with bronchial asthma. All patients underwent bilateral endoscopic polysinusotomy followed by case follow-up for a year. The diagnosis of bronchial asthma was made based on the diagnostic criteria defined in the Global Strategy for the Treatment and Prevention of Bronchial Asthma and in the Federal Clinical Guidelines for the Diagnosis and Treatment of Bronchial Asthma. All patients were consulted by a pulmonologist. Control examinations of patients were carried out every 3 months. All patients underwent a study of the concentration of periostin in the blood serum. Blood probe samples were taken before the start of treatment and after 12 months.Results and discussion. In the course of the study, was proved the relationship between a high concentration of serum periostin in combination with increased eosinophils of blood and nasal secretion with an early relapse of polyposis rhinosinusitis.Conclusions. An increased concentration of serum periostin before surgical treatment is a prognostically unfavorable factor for early recurrence of chronic rhinosinusitis with nasal polyps.
DEVELOPMENT, EVALUATION AND RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF QUERCETIN, ELLAGIC ACID AND KAEMPFEROL IN A POLYHERBAL FORMULATION
Authors: K. SHALINI , K. ILANGO 
Published: May 2021

Objective: The current study was planned to develop polyherbal tablet formulation, standardization and evaluation for mitigating the symptoms of polycystic ovarian syndrome (PCOS). To control the issue of PCOS in women by the utilization of newly developed polyherbal tablet formulation.
Methods: The polyherbal tablets were prepared using a hydroalcoholic extract of the selected medicinal plants viz. Asparagus racemosus, Bauhinia variegata, Caesalpinia bonducella, Saraca asoca, and Symplocos racemosa with the help of a super disintegrant addition technique using crospovidone, kyron T-314 and pregelatinized starch in various percentages. Evaluation assessments such as pre-formulation studies, weight variation, hardness, friability, thickness, disintegration, IR compatibility and simultaneous estimation of quercetin, ellagic acid and kaempferol by RP-HPLC method were done.
Results: The results reveal that preformulation and evaluation parameters were satisfactory and found to be within an acceptable limit. The Fourier transform infrared spectroscopy (FTIR) compatibility displays no chemical interaction amongst the hydroalcoholic extract of polyherbal formulation and excipients. In simultaneous estimation, the retention time of quercetin, ellagic acid, and kaempferol were found to be 4.86, 6.96 and 10.01 min respectively. The linearity of quercetin, ellagic acid and kaempferol were found in the range of 0-200 µg/ml with correlation coefficients (R2>0.997) within the tested ranges. The LOD and LOQ values of quercetin, ellagic acid and kaempferol were found to be 11.86, 2.63, 5.28 µg/ml and 35.95, 7.98, 16.00 µg/ml respectively. The % RSD values were found to be less than 2 showed the optimized method is precise.
Conclusion: To conclude, the prepared polyherbal tablet and its quality control analysis revealed satisfactory pharmaceutical properties that fulfill within the limits of pharmacopeial standards. The RP-HPLC method for simultaneous estimation of quercetin, ellagic acid and kaempferol were simple, precise, accurate and consistent for the quantitative analysis and quality control examination of herbal formulations.
Dobraduras Dinâmicas e a Argumentação em Geometria
Authors: Ferreira Silveira Priscila , Rodrigues Notare Márcia 
Published: May 2021

Nesse artigo analisa-se o desenvolvimento do pensamento geométrico e da argumentação a partir da exploração de situações geométricas de dobraduras em ambiente de geometria dinâmica. A investigação foi conduzida por um experimento, com alunos do nono ano do Ensino Fundamental. Por meio de investigação geométrica, foram elaboradas atividades dinâmicas, nas quais se oportunizou o desenvolvimento de aspectos essenciais do pensamento geométrico, como a exploração, formulação e teste de conjecturas, assim como o incentivo à argumentação na escola. Essa investigação foi realizada com o software GeoGebra, a partir da manipulação de objetos geométricos dinâmicos que simulam dobraduras em folhas de papel, nos quais os alunos foram incentivados a explorar e argumentar. Os resultados do experimento apontam que, com a utilização de ambiente de geometria dinâmica, é possível resgatar o trabalho com o desenvolvimento do pensamento geométrico na escola básica.
Reference range of naïve T and T memory lymphocyte subsets in peripheral blood of healthy adult
Authors: Xia Ying , Liu Aqing , Li Wentao , Liu Yunhe , Zhang Guan , Ye Songshan , Zhao Zhijieruo , Shi Juan , Yu Jianchun , Jia Yingjie , Liu Xu , Guo Yongtie , Chen Huayu 
Published: May 2021

Abstract: Background： Naïve T and T memory cell subsets can provide
important information for the diagnosis and treatment of immunological
and hematological disorders. Lymphocyte compartment undergo dramatic
changes during adulthood; age-related reference values derived from
healthy individuals are crucial. However, extensively detailed
immunophenotyping reference values of peripheral blood lymphocytes in
whole spectrum of adulthood performed by flow cytometry-based
single-platform method are rare. Methods: 309 healthy adult volunteers
were recruited from Tianjin in China. The absolute counts and
percentages of CD3+CD4+ T cells, CD3+CD8+ T cells, naïve T cells (Tn), T
memory stem cells (Tscm), central memory T cells (Tcm), effector memory
T cells (Tem), terminal effector T cells (Tte) were determined by flow
cytometry with single platform technologies. Results: Reference range of
absolute counts and percentage of lymphocyte subsets were formulated by
different age and gender. We also find out the changing regularity of
them: the cells which have stem cell properties, Tn and Tscm cells,
decrease with aging; memory cell subsets, Tcm and Tem increase with
aging, which increase from 18 to 64 years old and present no significant
change over the 65 years old. Gender have influence on the fluctuation
of lymphocyte subsets, absolute count of CD3+CD8+, CD8+ Tcm, CD8+ Tem in
male are higher than that in female. Conclusion: The reference values of
percentages and absolute numbers of naïve T and T memory cell subsets
can help doctors to understand the immune state of patients and to
evaluate conditions of prognosis then adjust treatment for patients.
Pasado y presente en la resistencia de los pueblos originarios de Norteamerica
Authors: Bozza Juan Alberto 
Published: May 2021

Este artículo analiza la vinculación entre la acción colectiva de las naciones originarias de Norteamérica y la revisión crítica del pasado americano. Describe el enfoque estigmatizador proyectado por la historiografía decimonónica hasta bien avanzado el siglo XX. Considera al movimiento por los derechos civiles de los años sesenta como la etapa matricial de la conciencia histórica india. Destaca el rol de las organizaciones militantes nativas que, fundadas en una visión alternativa y crítica del pasado, llevaron a cabo un conjunto de iniciativas encaminadas a la emancipación y autogobierno de los pueblos ancestrales. Estas acciones fueron decisivas para la construcción de una memoria de la resistencia de los pueblos nativos de Norteamérica.
Violencia política y género: Estudio de la militancia de mujeres comunistas durante el periodo de la Política de Rebelión Popular de Masas (1980-1990)
Authors: Robles Recabarren Javiera 
Published: May 2021

Revisión de Tesis Violencia política y género: Estudio de la militancia de mujeres comunistas durante el periodo de la Política de Rebelión Popular de Masas (1980-1990)
De-generar la formación docente en Educación Física
Authors: Bazán Eugenia , Bilo Mayra , Brandán Tatiana , Castro Franco , Gravano Ornella , Mármol Nicolas , Labaké Leticia , Rexach Patricia , Ciccone Santiago , Vieytes Manuel 
Published: May 2021

El presente artículo se enmarca en el proyecto de investigación “La buena enseñanza. Intervenciones docentes y evaluación en clave de géneros. Estudio en los Profesorados Universitarios de Educación Física de la UNLu y UdelaR”, de la Universidad Nacional de Luján, Argentina. El propósito es compartir un taller vivencial llevado a cabo en el “II Encuentro de Estudios en Deporte” de la Universidad de la República, Uruguay (UdelaR). Dicha instancia surge como necesidad de generar un espacio práctico de problematización e indagación sobre la educación física y su enseñanza con perspectiva de géneros en la trayectoria de la formación docente, con el objeto que los y las participantes practiquen, apropien y transfieran la perspectiva de géneros al desarrollo de sus prácticas docentes.
Test and Re-Test Reliability of the Special Judo Fitness Test
Authors: Štefanovský Miloš , Poliak Matej , Augustovičová Dušana , Kraček Stanislav , Hadža Radovan 
Published: May 2021

Summary

Background. When analyzing the available literature, we found differences and considerable variability in the Special Judo Fitness Test (SJFT) reliability methods.

Problems and Aim. For this reason, we have set our goal to determine the reliability and measurement error of all parameters by SJFT.

Methods. The research sample consisted of 15 judo athletes (17.13 ± 1.96 years, body height 174.4 ± 10.64 cm, body weight 72 ± 15.37 kg) who trained in judo on average 8.73 ± 2.12 years in two different Slovak judo clubs. The results were processed using interclass correlation analysis and measurement error percentage.

Results. Our results indicate poor reliability for HR0 (α= 0.374, Err = 4.2 %) and moderate reliability for the following parameters: the number of throws in section A (α = 0.641, Err = 5.9 %), section B (α = 0.512, Err = 6.0 %), and section C (α = 0.644, Err = 5.9 %), respectively. Moderate reliability was also found for the total number of throws (α = 0.687, Err = 5.1 %). Good reliability was found for HR1
(α = 0797, Err = 3.5 %) and SJFT index (α = 0.807, Err = 4.5 %).

Conclusions. According to the results of this study, by testing the special level of judo fitness, as well as its changes, we recommend using the HR1 and SJFT index as good reliable parameters.
Research of urban waterfront space planning and design based on children-friendly idea
Authors: Jiao Hong , Liu Zehua 
Published: May 2021

Abstract
The natural environment is vital for the healthy growth of children. The absence of exposure to Nature in cities is an important cause of physical and psychological health problems in children. With the objective of a healthy growth environment for children, this paper states the active role of the urban waterfront space, analyses the relationship between children and urban waterfront space, summarises the characteristics of children’s outdoor activities, proposes the principle and methods of planning and designing a children-friendly urban waterfront space, and provides some improved design strategies.
Experimental Work to Study the Strengthening Effect of SFR and CFRP on a Part or Whole of the Length of Slender RC Columns
Authors: Al-Helfi Mohammed , Allami Ali 
Published: May 2021

Abstract
This paper is focussed on the investigation of the strengthened column by steel-fibre-reinforced (SFR) and carbon fibre-reinforced polymer (CFRP) on a part or a whole of the length of the column under axial force, and to obtain the effective length, which is responsible for the increasing of the ability of the column to resist buckling. Seven samples were designed as slender reinforced columns with dimensions of 2000 mm length and cross-sections of 120 mm x 60 mm. It was shown that the strengthening of the middle half of the column length by SFR gave an ultimate load similar to the strengthening of the whole column with same material. Also, it was found that the column strengthened by SFR increased its ultimate load by 42.6 %, 42.1 % and 33.3 % for strengthened lengths of dimensions L, L/2 and L/3, respectively, compared to the non-strengthened column. The increase in ultimate load that could be borne by the column strengthened by CFRP were 53.0 % and 33.8 % for strengthened lengths of L and L/2, respectively, only. Interaction diagram had been depended as a theoretical analysis for slender concrete columns. The interaction diagram for the column strengthened by CFRP is greater than for the column strengthened by SFR, which in turn is greater than the non-strengthened column.