bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between serum zonulin level and severity of house dust mite allergic asthma
Authors: Baioumy Shereen A. , Elgendy Aya , Ibrahim Shereen M. , Taha Sara I. , Fouad Shaimaa H. 
Published: August 2021

Abstract
Background
Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, plays a critical role in susceptibility to environmental allergens. House dust mite allergy occurs more commonly than any other type of allergy among Egyptian asthmatic patients.

Aim
To assess the relation between serum zonulin level as a marker of increased intestinal permeability and the severity of house dust mite allergic asthma.

Methods
A case–control study which included 48 patients with house dust mite allergic asthma and 48 healthy control subjects attending the Allergy and Immunology Unit, Microbiology and Immunology Department, Faculty of Medicine, Zagazig University.

Results
A statistically significant difference was detected between the two studied groups with respect to serum IgE and serum zonulin levels (p ˂ 0.001 and ˂ 0.001, respectively). The mean serum zonulin was equal to 258.3 ± 153.01 ng/ml in the asthmatic group and 80 ± 13 ng/ml in the control group. Serum zonulin level significantly increased with the increase of asthma severity (p ˂ 0.001). The cut off value of serum zonulin was ≥ 198 ng/ml, and the area under the curve was 0.76. It displayed sensitivity equal to 80% and specificity equal to 71.4%. Its negative predictive value was equal to 83.3%.

Conclusion
Intestinal barrier dysfunction contributes to the pathogenesis of allergic asthma. Serum zonulin level reflects an increase in intestinal permeability. Zonulin acts as prognostic factor of severity in asthma. Correction of the gut barrier defect may have a potential positive prognostic effect in asthma.
Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma
Authors: Luo Jun-hua , Zhu Yun-hua , Xiang Cheng 
Published: August 2021

Abstract
Background
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) has been proved to play a vital role in human cancers. Nevertheless, the exact role of ENTPD1 in thyroid carcinoma (THCA) remained unclear. This study aimed to evaluate its prognostic value and reveal the potential regulatory mechanism in THCA.

Results
(1) Higher expression of ENTPD1 was found in THCA tissue compared with normal tissue (all P < 0.05). ENTPD1 expression was associated with age, sub-type and clinical stage of THCA patients (all P < 0.05). Immunohistochemistry showed its higher expression in patients with early stage. (2) ENTPD1 high expression was associated with favorable overall survival of THCA patients (all P < 0.05), especially for male patients and those with advanced stage, B-cells and Natural killer T-cells decreased (all P < 0.05). (3) Pathway analysis indicated that ENTPD1 mainly participated in metabolic process and negatively regulated metabolism-related pathway such as butanoate metabolism, pyruvate metabolism and fatty acid metabolism ((all P < 0.05). (4) ENTPD1 appeared genetic alteration in THCA, and the main mutation type of ENTPD1 was missense substitution (15.89%). (5) A weak correlation between ENTPD1 expression and methylation was found (P < 0.001). Methylation of ENTPD1 in THCA was lower than in normal group (P < 0.001), but it did not correlate with any clinical phenotypes of THCA patients.

Conclusions
ENTPD1 was highly expressed in THCA, and ENTPD1 high expression contributed to the prognosis of THCA patients. The present study inferred that ENTPD1 might serve as a metabolism-related gene and play a critical role in THCA through regulating metabolic pathways.
Masters & Johnson – their unique contribution to sexology
Authors: Wylie Kevan 
Published: August 2021

SUMMARYThe scientific study of human sexuality is now accepted as mainstream practice but early researchers in the field often attracted considerable criticism. Masters and Johnson were pioneers in observing and describing normal sexual function and consequently they provided unique insights into helping to understand sexual dysfunction. Their contribution to describing the physiological process of sexual response alongside potential psychological factors resulting in and maintaining sexual dysfunction is widely acknowledged. Their work continues to influence contemporary sexual medicine and psychosexual therapeutic practice.
Determinants of Risk-Aligned Bladder Cancer Surveillance—Mixed-Methods Evaluation Using the Tailored Implementation for Chronic Diseases Framework
Authors: Schroeck Florian R. , Ould Ismail A. Aziz , Perry Grace N. , Haggstrom David A. , Sanchez Steven L. , Walker DeRon R. , Young Jeanette , Zickmund Susan , Zubkoff Lisa 
Published: August 2021

PURPOSE: For many patients with cancer, the frequency of surveillance after primary treatment depends on the risk for cancer recurrence or progression. Lack of risk-aligned surveillance means too many unnecessary surveillance procedures for low-risk patients and not enough for high-risk patients. Using bladder cancer as an example, we examined whether practice determinants differ between Department of Veterans Affairs sites where risk-aligned surveillance was more (risk-aligned sites) or less common (need improvement sites). METHODS: We used our prior quantitative data to identify two risk-aligned sites and four need improvement sites. We performed semistructured interviews with 40 Veterans Affairs staff guided by the Tailored Implementation for Chronic Diseases framework that were deductively coded. We integrated quantitative data (risk-aligned site v need improvement site) and qualitative data from interviews, cross-tabulating salient determinants by site type. RESULTS: There were 14 participants from risk-aligned sites and 26 participants from need improvement sites. Irrespective of site type, we found a lack of knowledge on guideline recommendations. Additional salient determinants at need improvement sites were a lack of resources (“the next available without overbooking is probably seven to eight weeks out”) and an absence of routines to incorporate risk-aligned surveillance (“I have my own guidelines that I've been using for 35 years”). CONCLUSION: Knowledge, resources, and lack of routines were salient barriers to risk-aligned bladder cancer surveillance. Implementation strategies addressing knowledge and resources can likely contribute to more risk-aligned surveillance. In addition, reminders for providers to incorporate risk into their surveillance plans may improve their routines.
The diagnostic value of hepatobiliary scintigraphy for choledochal cysts in the era of magnetic resonance imaging with cholangiopancreatography and contrast-enhanced hepatobiliary phase: a case report and review
Authors: Chan Tak Kwong , Luk Wing Hang , Ng Fung Him , Chan Rois L.S. , Hui Yan Ho , Chan Chung Yan Justin , Cheung Wai Hung 
Published: August 2021

Objective: Choledochal cysts (CCs) represent cystic dilatations of the intra- or extrahepatic biliary tract. The diagnosis of CCs may not always be straightforward particularly for the intrahepatic subtype. Whereas the gold standard for diagnosing CCs is endoscopic retrograde cholangiopancreatography (ERCP), magnetic resonance cholangiopancreatography (MRCP) is commonly used as primary diagnostic tool for delineation of biliary pathologies including CCs. Methods: We report a case of cystic hepatic lesion near the confluence of bilateral intrahepatic ducts. MRCP shows direct anatomical communication between the lesion and the biliary tract, raising suspicion of a CC. Endoscopic ultrasound shows no communication between the lesion and biliary system. 99mTc-hepatic iminodiacetic acid scintigraphy (hepatobiliary scintigraphy) was subsequently performed, showing no tracer uptake in the concerned cystic hepatic lesion despite visualisation of gallbladder and transit of tracer into the intestine. Overall scintigraphic findings speak against a CC. Conclusion: The case showed conflicting anatomical findings of a CC on MRCP and endoscopic ultrasound. Hepatobiliary scintigraphy and hepatobiliary contrast MRI may both functionally demonstrate communication of a hepatic lesion with the biliary tract. But hepatobiliary scintigraphy offers the advantage of much higher hepatic extraction and hence higher resistance to competition from plasma bilirubin compared with hepatobiliary contrast MRI. The better pharmacokinetics of HIDA confer superior lesion contrast that may offset inferior image spatial resolution, in particular for large lesions and patients with hyperbilirubinaemia. Hepatobiliary scintigraphy should be considered a suitable functional diagnostic modality for CCs even in the era of magnetic resonance imaging with cholangiopancreatography and contrast-enhanced hepatobiliary phase.
Αναπρογραμματισμός του μεταβολισμού του Lotus japonicus σε μεταγραφικό, βιοχημικό και μεταβολομικό επίπεδο κατά τη συμβιωτική αζωτοδέσμευση
Authors: Καλλονιάτη Χρυσάνθη 
Published: August 2021

Symbiotic nitrogen fixation in legumes takes place in specialized organs called nodules,which become the main source of assimilated nitrogen for the whole plant. Symbiotic nitro‐gen fixation requires exquisite integration of plant and bacterial metabolism and involvesglobal changes in gene expression and metabolite accumulation in both rhizobia and thehost plant. In order to study the metabolic changes mediated by symbiotic nitrogen fixationon a whole‐plant level, metabolite levels were profiled by gas chromatography–mass spec‐trometry in nodules and non‐symbiotic organs of Lotus japonicus plants uninoculated or in‐oculated with M. loti wt, ΔnifA or ΔnifH fix‐ strains. Furthermore, transcriptomic andbiochemical approaches were combined to study sulfur metabolism in nodules, its link tosymbiotic nitrogen fixation, and the effect of nodules on whole‐plant sulfur partitioning andmetabolism. It is well established that nitrogen and sulfur (S) metabolism are tightly en‐twined and sulfur is required for symbiotic nitrogen fixation, however, little is known aboutthe molecular and biochemical mechanisms governing sulfur uptake and assimilation duringsymbiotic nitrogen fixation. Transcript profiling in Lotus japonicus was combined with quan‐tification of S‐metabolite contents and APR activity in nodules and in non‐symbiotic organsof plants uninoculated or inoculated with M. loti wt, ΔnifA or ΔnifH fix‐ strains. Moreover,sulfate uptake and its distribution into different plant organs were analyzed and 35S‐flux intodifferent S‐pools was monitored. Metabolite profiling revealed that symbiotic nitrogen fixa‐tion results in dramatic changes of many aspects of primary and secondary metabolism innodules which leads to global reprogramming of metabolism of the model legume on awhole‐plant level. Moreover, our data revealed that nitrogen fixing nodules represent athiol‐rich organ. Their high APR activity and 35S‐flux into cysteine and its metabolites in com‐bination with the transcriptional up‐regulation of several genes involved in sulfur assimila‐tion highlight the function of nodules as a new site of sulfur assimilation. The higher thiolcontent observed in non‐symbiotic organs of nitrogen fixing plants in comparison touninoculated plants cannot be attributed to local biosynthesis, indicating that nodules couldserve as a novel source of reduced sulfur for the plant, which triggers whole‐plant repro‐gramming of sulfur metabolism. Interestingly, the changes in metabolite profiling and theenhanced thiol biosynthesis in nodules and their impact on the whole‐plant sulfur, carbonand nitrogen economy are dampened in fix‐ plants, which in most respects metabolically re‐sembled uninoculated plants, indicating a strong interaction between nitrogen fixation andsulfur and carbon metabolism.
Μελέτη σχέσης δομής - βιολογικής δράσης αντιϋπερτασικών ενώσεων μέσω τεχνικών μοριακής μοντελοποίησης και φασματοσκοπίας πυρηνικού μαγνητικού συντονισμού (NMR)
Authors: Ματσούκας Μίνως-Τιμόθεος 
Published: August 2021

Η αρτηριακή πίεση ρυθμίζεται μέσω του συστήματος ρενίνης-­‐αγγειοτασίνης στο οποίο εμπλέκονται ο υποδοχέας της αγγειοτασίνης ΙΙ και η ρενίνη. Στην παρούσα ερευνητική εργασία, χρησιμοποιήθηκαν in silico τεχνικές για τη μελέτη της λειτουργίας των συμπλόκων αυτών των πρωτεϊνών με τους βιοδραστικούς προσδέτες τους. Μελετήθηκαν οι διαμορφωτικές και ενεργειακές αλλαγές στις οποίες υπόκειται η αλισκιρένη κατά την πρόσδεση στη ρενίνη και τα δομικά χαρακτηριστικά των συμπλόκων μεταξύ της αγγειοτασίνης ΙΙ και ενός μεγάλου αριθμού ανταγωνιστών της με τον υποδοχέα της (ΑΤ1). Στους υπολογισμούς ενσωματώθηκαν πειραματικά δεδομένα σχετικά με τη διαμόρφωση ή την ισχύ πρόσδεσης αυτών των μορίων προκειμένου να δημιουργηθούν αξιόπιστα μοντέλα που να προσομοιάζουν την βιολογική δράση αυτών των συμπλόκων και να χρησιμοποιηθούν για σχεδιασμό νέων δραστικών ενώσεων.
Regional disparities and their contribution to the coverage of the tetanus toxoid vaccine among women aged 15–49 years in Indonesia
Authors: Arifin Hidayat , Widiasih Restuning , Pradipta Rifky Octavia , Kurniawati Yulia 
Published: August 2021

Background: The prevention of Clostridium tetani bacterial infection through the administration of the tetanus toxoid (TT) vaccine in women is important. The purpose of this study was to determine the regional disparities and factors associated with TT vaccine coverage in women aged 15–49 years in Indonesia. Methods: The Indonesian Demographic Health Survey (IDHS) 2017 data was used in this study. A total of 36,028 women, aged 15–49 years were recruited using the two-stage stratified cluster sampling technique. The questionnaire used was based on the DHS Questionnaire Phase 7. Chi-squared and binary logistic regression were used in this study as part of the analysis. Results: We found that the TT vaccine coverage was 75.32% and that the majority were spread across several provinces. The provinces of Bali and Nusa Tenggara, the richer respondents, living in a rural area, visiting the health facility, having health insurance, and those currently working were factors making it more likely that the women would receive the TT vaccine. The respondents aged 15–24 years with a primary education level and the respondents who were divorced were less likely to receive the TT vaccine. Conclusion: The coverage of the TT vaccine among women can be increased by considering the regional disparities in Indonesia and the socio-economic demographic details of the respondents. Strengthening the policies from the central government in the local governments can improve the screening process and vaccine delivery outcomes. In addition, the importance of giving the TT vaccine to women needs to be relayed through health education in collaboration between health workers and the public.
Driving-induced lower back pain: Investigation of causes and recommendations with TRIZ
Authors: Ng Poh Kiat , Mohamed Muhammad Syafiq Syed , Yeow Jian Ai 
Published: August 2021

Background: Driving-induced lower back pain (DLBP) is associated with long driving times and awkward postures. Nonetheless, its actual causes and solutions remain unclear due to intervening causes from activities of daily living and traumatic injuries. This study investigated the causes and recommendations for DLBP using the theory of inventive problem solving (TRIZ). Methods: A cause-and-effect chain analysis (CECA) was conducted based on discussions with 19 ergonomics experts from Malaysia. Engineering contradictions were formulated according to the causes and associated with the parameters of the TRIZ system. These parameters were then intersected in the contradiction matrix to extract the inventive principles. Finally, recommendations were made based on these principles. Results: CECA uncovered the design- and posture-related causes of DLBP. It was implied that missing seat adjustment controls might cause drivers to sit with their knees positioned higher than their hips. This issue causes an excessive posterior pelvic tilt, resulting in DLBP. To address this issue, an inert atmosphere involving the addition of inflatable bubble wraps to elevate the posterior position was recommended. Conclusion: While there have been studies on DLBP, the present study demonstrated originality by using TRIZ to preliminarily but systematically investigate and resolve DLBP. Further triangulations, prototyping, experimentations, and verifications were not possible due to time and budgetary constraints. Nevertheless, this research uncovered the TRIZ-integrated perspectives on ergonomic solutions to DLBP that are more cost-effective than medical treatments or design overhauls.
Trauma, Narrative and History: Representation of Traumatic Experience in the Works of Algirdas Landsbergis
Authors: Bankauskaitė Gabija , Huber Loreta 
Published: August 2021

The twentieth century witnessed an abundant number of traumatic events related to dark history. Trauma caused by war, occupation, exile, repression, gave rise to migration or mass murder. To rely upon Cathy Caruth (1996: 3), the concept of trauma is understood as a physical wound; however, subsequently in medicine and the literature of psychiatry, especially in Freud’s works, the concept of trauma came to be understood as a psychological wound. In addition, trauma is not only a disturbing or stressful experience that affects an individual physically or psychologically, it may also be based on other factors created by society.
Over time the field of trauma in various contexts expanded so that today it is widely used in sociology when analysing historical and cultural events. Cultural traumatic memory is mirrored in trauma fiction that conveys the experience of loss and suffering, there is a space for memories, introspection, recollections, flashbacks and awful remembrances that are colored by pain. Apart from individual, event-based trauma, there is another category of trauma variously called cultural or historical trauma, which affects groups of people.
Numerous studies have been conducted on the latter topic, however, trauma and its expression in Lithuanian literature has not yet been sufficiently documented.
The aim of this study is to discuss the concepts of cultural and historical trauma and the way trauma is reflected in Algirdas Jeronimas Landsbergis’ works. The authors of the study claim that Landsbergis – one of many Lithuanian writers-in-exile – wrote texts that fill a cultural vacuum and invite a re-discussion of what was most painful in the past.
Dinner with Mock Faustus: Multilingual Cuisine Cooks the Identity
Authors: Laizāns Mārtiņš 
Published: August 2021

Phenomena related to gastronomy form an important part of both individual and collective identities. The gastronomical dimensions of literature can often be perceived as a commentary on the political, historical and societal, going beyond just the food. As cuisines are becoming more mixed globally, languages describing gastronomical scenes in literature are also becoming more multilingual.
The novel Mock Faustus (1973), by the Latvian writer Marģers Zariņš, fuses the gastronomical and the multilingual to the extreme, producing a utopian linguistic hybrid of the Latvian language to which a mix of foreign languages and countless intertextual references are added. This is achieved by the gastronomical vocabulary and imagery omnipresent in the narrative of writing a fictional cookbook. The depiction of gastronomical phenomena allows Zariņš to indirectly comment on Latvian history from the 1930s to 1945 and the confused and fragmented identities of these times.
O levar da “honra e virgindade”
Authors: Massuchetto Vanessa Caroline 
Published: August 2021

Este artigo trata de dois casos de estupro ocorridos na vila de Curitiba, processados pelo juízo ordinário e pela ouvidoria de Paranaguá na segunda metade do século XVIII. O objetivo principal é lançar luzes sobre as trajetórias femininas, as estratégias sociais e a cultura jurídica criminal local.
PALAVRAS-CHAVE: América Portuguesa. Vila de Curitiba. Cultura Jurídica Criminal. Estupro. Relações de Gênero.
A percepção do empoderamento feminino em relação ao exame papanicolau uma nova abordagem para prevenção do colo do útero
Authors: Lima Adeânio Almeida , Biscarde Genilberta Meireles 
Published: August 2021

Na atenção básica de saúde, é ofertado o exame Papanicolau, que desempenha umas das funções de detecção precoce da alteração das células e são curáveis na quase totalidade dos casos. De acordo algumas literaturas e mídias informativas jornalísticas está acontecendo uma evasão de mulheres para realização do exame, pois estimam-se 16.370 casos novos de câncer do colo do útero para cada ano. Dessa forma, surge um grande paradoxo, se temos o exame Papanicolau para detecção precoce do câncer do colo de útero com estimativas de cura se descoberto em estágios iniciais, eis a inquietação, porque as mulheres não estão fazendo o exame. O objetivo do estudo foi analisar e identificar a percepção do empoderamento e os sentimentos das mulheres ao exame Papanicolau na atenção básica de saúde.A pesquisa possui caráter de campo, optou-se pela abordagem qualitativa e descritiva. Como campo escolhido, utilizou-se a Estratégia de Saúde da família da Santa Terezinha, localizada na cidade de Nova Soure-BA com o foco em mulheres maiores de dezoitos anos usuárias do serviço de saúde com aplicação de um questionário semi estruturado, onde ocorreu a participação de vinte e cinco mulheres. Desta forma é de extrema urgência avaliar de forma holística a situação da oferta do planejamento familiar na realização do exame Papanicolau para a integralidade da saúde da mulher com a implementação do PAISM.
PALAVRAS-CHAVE: Planejamento Familiar. Empoderamento. Preventivo.
Entre a fêmea fatal e a fatalidade
Authors: Souza Valeska Bassi de 
Published: August 2021

Este trabalho buscou analisar, a partir de uma ação de desquite, como uma mulher construiu sua subjetividade por meio das suas experiências de vida amorosa, dos seus desejos e das suas dores. Temas como casamento, adultério, condição feminina, prostituição e desquite são tratados em diálogo com algumas autoras feministas.
PALAVRAS-CHAVE: Subjetividade Feminina. Sensibilidades. Gênero. Desquite. Adultério.
O que é ser mulher no rural contemporâneo
Authors: Franzmann Adriana , Lima Romilda de Souza 
Published: August 2021

Esta pesquisa analisa a autopercepção feminina quanto à identidade rural, urbana ou rural-urbana contida no discurso desse grupo. Trata-se de uma análise de abordagem qualitativa e etnográfica e a ancoragem teórica é sobretudo da sociologia rural. Foram realizadas entrevistas com 30 mulheres do município de Marechal Cândido Rondon, no Paraná. Todas elas moradoras do campo, em sítios dos quais são proprietárias junto com a família. Desse total, 15 trabalham na cidade e retornam ao sítio diariamente e 15 trabalham apenas nos sítios. Ao falarmos do lugar dessas mulheres, não o fazemos apenas enquanto local geográfico e físico, mas, sobretudo, àquele conectado ao territorial, cultural e social, diretamente perpassados pela identidade, que tem forte presença das relações étnicas, neste caso, da “germanidade” que é característica no município, em função da colonização. Ao final da pesquisa concluímos que essas mulheres demonstram uma relação direta entre campo e cidade, refletida em seus modos de vida, mesmo morando no sítio. Isso se dá inclusive para aquelas que não trabalham fora do sítio, mas que estabelecem estreita conexão de dependência com o meio urbano seja para trocas comerciais ou para socialização.
PALAVRAS-CHAVE: Rural-Urbano. Identidade. Gênero. Mulheres.