bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insomnia and circadian sleep disorders in ovarian cancer: Evaluation and management of underestimated modifiable factors potentially contributing to morbidity
Authors: Palagini Laura , Miniati Mario , Massa Lucia , Folesani Federica , Marazziti Donatella , Grassi Luigi , Riemann Dieter 
Published: October 2021

AbstractOvarian cancer is the leading cause of gynaecological cancer deaths and the seventh most commonly diagnosed cancer among women worldwide, so that, as it is related to substantial and increasing disease burden, the management of ovarian cancer survivors should be a priority. Such issues involve prevention and management of emotional distress, anxiety/depressive symptoms, and maintenance of quality of life from initial diagnosis to post‐treatment. Within this framework, sleep disturbances, in particular insomnia, are emerging as modifiable determinants of mental health, also contributing to substantial morbidity among cancer, including ovarian cancer. To this aim we conducted a systematic review according to PRISMA guidelines on prevalence and management of insomnia and circadian sleep disorders in ovarian cancer, while selecting 22 papers. Insomnia was evaluated in ovarian cancer and, while circadian sleep disturbances were poorly assessed in ovarian cancer, insomnia increased from 14% to 60% of patients. Insomnia was associated with cancer‐related comorbid conditions such as emotional distress, anxiety/depressive symptoms and low quality of life. Despite this evidence, no studies have been conducted about insomnia treatment in ovarian cancer. The burden of insomnia and circadian sleep disorders in patients with ovarian cancer still needs to be addressed, and requires a call to action for the evaluation and management of these potential modifiable factors that might contribute to ovarian cancer morbidity.
Immunoglobulin G and phosphatidylserine in regenerative and nonregenerative immune‐mediated anemias of dogs
Authors: Lucidi Cynthia A. , Gerlach John A. , Jutkowitz Ari , Scott Michael A. 
Published: October 2021

AbstractBackgroundAlthough precursor‐targeted immune‐mediated anemia (PIMA) is thought to be caused by immune targeting of erythroid precursors (nucleated RBCs, nRBCs), its pathogenesis is unknown. Immunoglobulin G (IgG) or phosphatidylserine (PS) may promote nRBC destruction in PIMA.HypothesisDogs with PIMA have increased nRBC IgG and PS, and dogs with immune‐mediated hemolytic anemia (IMHA) have increased RBC PS compared to healthy dogs.AnimalsBlood from 20 healthy dogs and from dogs with IMHA (11) or other (non‐IMHA) conditions (9), and marrow aspirates with or without blood from 10 healthy dogs and from dogs with PIMA (17) or other (non‐IMHA, non‐PIMA) conditions (7).MethodsMarrow nRBC stages were separated by density gradient. Flow cytometry was used to assess the percentage of RBCs or nRBCs with increased IgG or PS.ResultsRed blood cell (RBC) IgG positivity was increased in 9/11 IMHA dogs and 0/9 non‐IMHA dogs. Red blood cell PS positivity was increased in 10/11 IMHA dogs and 2/9 non‐IMHA dogs. Five of 17 PIMA dogs had increased nRBC IgG positivity in mid‐ or late‐stage fractions, whereas all 7 non‐PIMA dogs were negative. Mid‐ and late‐stage erythroid precursor PS was significantly higher in PIMA dogs compared to healthy dogs. Five of 14 PIMA dogs had increased RBC IgG positivity.ConclusionsImmunoglobulin G and PS may promote destruction of nRBCs in PIMA dogs; PS may promote destruction of RBCs in IMHA dogs.
Refining the genomic location of single nucleotide polymorphism variation affecting Atlantic salmon maturation timing at a key large‐effect locus
Authors: Sinclair‐Waters Marion , Piavchenko Nikolai , Ruokolainen Annukka , Aykanat Tutku , Erkinaro Jaakko , Primmer Craig R. 
Published: October 2021

AbstractEfforts to understand the genetic underpinnings of phenotypic variation are becoming more and more frequent in molecular ecology. Such efforts often lead to the identification of candidate regions showing signals of association and/or selection. These regions may contain multiple genes and therefore validation of which genes are actually responsible for the signal is required. In Atlantic salmon (Salmo salar), a large‐effect locus for maturation timing, an ecologically important trait, occurs in a genomic region including two genes, vgll3 and akap11, but data for clearly determining which of the genes (or both) contribute to the association have been lacking. Here, we take advantage of natural recombination events detected between the two candidate genes in a salmon broodstock to reduce linkage disequilibrium at the locus, thus enabling delineation of the influence of variation at these two genes on early maturation. By rearing 5,895 males to maturation age, of which 81% had recombinant vgll3/akap11 allelic combinations, we found that vgll3 single nucleotide polymorphism (SNP) variation was strongly associated with early maturation, whereas there was little or no association between akap11 SNP variation and early maturation. These findings provide strong evidence supporting vgll3 as the primary candidate gene in the chromosome 25 locus for influencing early maturation. This will help guide future research for understanding the genetic processes controlling early maturation. This also exemplifies the utility of natural recombinants to more precisely map causal variation underlying ecologically important phenotypic diversity.
Individual tree damage dominates mortality risk factors across six tropical forests
Authors: Zuleta Daniel , Arellano Gabriel , Muller‐Landau Helene C. , McMahon Sean M. , Aguilar Salomón , Bunyavejchewin Sarayudh , Cárdenas Dairon , Chang‐Yang Chia‐Hao , Duque Alvaro , Mitre David , Nasardin Musalmah , Pérez Rolando , Sun I‐Fang , Yao Tze Leong , Davies Stuart J. 
Published: October 2021

Summary

The relative importance of tree mortality risk factors remains unknown, especially in diverse tropical forests where species may vary widely in their responses to particular conditions.

We present a new framework for quantifying the importance of mortality risk factors and apply it to compare 19 risks on 31 203 trees (1977 species) in 14 one‐year periods in six tropical forests. We defined a condition as a risk factor for a species if it was associated with at least a doubling of mortality rate in univariate analyses. For each risk, we estimated prevalence (frequency), lethality (difference in mortality between trees with and without the risk) and impact (‘excess mortality’ associated with the risk, relative to stand‐level mortality).

The most impactful risk factors were light limitation and crown/trunk loss; the most prevalent were light limitation and small size; the most lethal were leaf damage and wounds. Modes of death (standing, broken and uprooted) had limited links with previous conditions and mortality risk factors.

We provide the first ranking of importance of tree‐level mortality risk factors in tropical forests. Future research should focus on the links between these risks, their climatic drivers and the physiological processes to enable mechanistic predictions of future tree mortality.
Sucrose promotes D53 accumulation and tillering in rice
Authors: Patil Suyash B. , Barbier Francois F. , Zhao Jinfeng , Zafar Syed A. , Uzair Muhammad , Sun Yinglu , Fang Jingjing , Perez‐Garcia Maria‐Dolores , Bertheloot Jessica , Sakr Soulaiman , Fichtner Franziska , Chabikwa Tinashe G. , Yuan Shoujiang , Beveridge Christine A. , Li Xueyong 
Published: October 2021

Summary

Shoot branching is regulated by multiple signals. Previous studies have indicated that sucrose may promote shoot branching through suppressing the inhibitory effect of the hormone strigolactone (SL). However, the molecular mechanisms underlying this effect are unknown.

Here, we used molecular and genetic tools to identify the molecular targets underlying the antagonistic interaction between sucrose and SL.

We showed that sucrose antagonizes the suppressive action of SL on tillering in rice and on the degradation of D53, a major target of SL signalling. Sucrose inhibits the gene expression of D3, the orthologue of the Arabidopsis F‐box MAX2 required for SL signalling. Overexpression of D3 antagonizes sucrose inhibition of D53 degradation and enables the SL inhibition of tillering under high sucrose. Sucrose prevents SL‐induced degradation of D14, the SL receptor involved in D53 degradation. In contrast to D3, D14 overexpression enhances D53 protein levels and sucrose‐induced tillering, even in the presence of SL.

Our results show that sucrose inhibits SL response by affecting key components of SL signalling and, together with previous studies reporting the inhibition of SL synthesis by nitrate and phosphate, demonstrate the central role played by SLs in the regulation of plant architecture by nutrients.
A sugarcane smut fungus effector simulates the host endogenous elicitor peptide to suppress plant immunity
Authors: Ling Hui , Fu Xueqin , Huang Ning , Zhong Zaofa , Su Weihua , Lin Wenxiong , Cui Haitao , Que Youxiong 
Published: October 2021

Summary

The smut fungus Sporisorium scitamineum causes the most prevalent disease on sugarcane. The mechanism of its pathogenesis, especially the functions and host targets of its effector proteins, are unknown.

In order to identify putative effectors involving in S. scitamineum infection, a weighted gene co‐expression network analysis was conducted based on the transcriptome profiles of both smut fungus and sugarcane using a customized microarray. A smut effector gene, termed SsPele1, showed strong co‐expression with sugarcane PLANT ELICITOR PEPTIDE RECEPTOR1 (ScPEPR1), which encodes a receptor like kinase for perception of plant elicitor peptide1 (ScPep1). The relationship between SsPele1 and ScPEPR1, and the biological function of SsPele1 were characterized in this study.

The SsPele1 C‐terminus contains a plant elicitor peptide‐like motif, by which SsPele1 interacts strongly with ScPEPR1. Strikingly, the perception of ScPep1 on ScPEPR1 is competed by SsPele1 association, leading to the suppression of ScPEPR1‐mediated immune responses. Moreover, the Ustilago maydis effector UmPele1, an ortholog of SsPele1, promotes fungal virulence using the same strategy.

This study reveals a novel strategy by which a fungal effector can mimic the plant elicitor peptide to complete its perception and attenuate receptor‐activated immunity.
Enhanced job satisfaction under tighter technological control: The paradoxical outcomes of digitalisation
Authors: Bisht Nidhi S. , Trusson Clive , Siwale Juliana , Ravishankar M. N. 
Published: October 2021

AbstractVia a multiple case study of work in microfinance institutions in India, this paper reports on the experiences of field officers and branch managers following work digitalisation. It identifies and explains an intriguing post‐digitalisation paradox of reported increased job satisfaction and tighter technological control diminishing branch managers' work‐life balance. The paradox draws attention to the significance of context in workers' experiences of mobile digital technologies (MDTs) and contradicts previous studies on workers' positive experiences of adopting MDTs: the workers in this study did not experience greater autonomy or flexibility but reported enhanced employment security and status. The paper also adds to literature on employment relations following work digitalisation by revealing powerful enforcement of technological control, with ‘WhatsApp’ identified as a key managerial tool used for surveillance and discipline, and worker resistance at the margins.
Root dynamic growth strategies in response to salinity
Authors: Zou Yutao , Zhang Yanxia , Testerink Christa 
Published: October 2021

AbstractIncreasing soil salinization largely impacts crop yield worldwide. To deal with salinity stress, plants exhibit an array of responses, including root system architecture remodelling. Here, we review recent progress in physiological, developmental and cellular mechanisms of root growth responses to salinity. Most recent research in modulation of root branching, root tropisms, as well as in root cell wall modifications under salinity stress, is discussed in the context of the contribution of these responses to overall plant performance. We highlight the power of natural variation approaches revealing novel potential pathways responsible for differences in root salt stress responses. Together, these new findings promote our understanding of how salt shapes the root phenotype, which may provide potential avenues for engineering crops with better yield and survival in saline soils.
What COVID‐19 has taught us about social inequities and the urgent need for systemic change
Authors: Wright Toni , Sah Rajeeb Kumar , Keys Clare , Nanayakkara Gowri , Onyejekwe Chisa 
Published: October 2021

AbstractThis paper critically comments on the state of affairs in the UK relating to the pandemic and explores how a focus on inequities experienced by marginalized and vulnerable groups is necessary for exposing the material realties of everyday life, but also how such a focus has been hijacked by center right politics to distract us from collective responsibilities and building alliances for systemic change. The paper critically reviews the impact of the COVID‐19 pandemic on the most marginalized and vulnerable in UK society and highlights the interconnected risk factors of COVID‐19 and its secondary impacts to demonstrate how these are linked to political ideology, policy, and practice. We conclude with recommendations informed through a looking back at the key tenants and purposes of universal healthcare to apprise what is needed in this moment of crisis and beyond.
The use of motivational interviewing to overcome COVID‐19 vaccine hesitancy in primary care settings
Authors: Breckenridge Leigh Ann , Burns Dana , Nye Carla 
Published: October 2021

AbstractVaccine hesitancy is not a new phenomenon. However, the COVID‐19 pandemic has highlighted the impact of political, racial, and health disparities on vaccine hesitancy at a global level. With the creation of the COVID‐19 vaccine, a resurgence of vaccine hesitancy has emerged and many are reluctant to receive the vaccination. The reluctance varies from concerns about government interference in vaccine development, to the speed of vaccine development, to long‐term health outcomes and potential side effects. Health care professionals need to consider evidence‐based approaches that are effective in assisting patients with health care decision‐making regarding vaccine uptake. Motivational Interviewing (MI) is an effective technique to positively impact behavior change. Definitions and examples of MI techniques are provided to illustrate how MI can be used to support patient autonomy and provide a safe and trusting environment, with the goal of increasing COVID‐19 vaccination uptake.
The effect of two retraining programs, barefoot running vs increasing cadence, on kinematic parameters: A randomized controlled trial
Authors: Molina‐Molina Alejandro , Latorre‐Román Pedro Ángel , Mercado‐Palomino Elia , Delgado‐García Gabriel , Richards Jim , Soto‐Hermoso Víctor Manuel 
Published: October 2021

The aim of this study was to compare the effects of two 10‐week non‐laboratory‐based running retraining programs on foot kinematics and spatiotemporal parameters in recreational runners. One hundred and three recreational runners (30 ± 7.2 years old, 39% females) were randomly assigned to either: a barefoot retraining group (BAR) with 3 sessions/week over 10 weeks, a cadence retraining group (CAD) who increased cadence by 10% again with 3 sessions/week over 10 weeks and a control group (CON) who did not perform any retraining. The footstrike pattern, footstrike angle (FSA), and spatial‐temporal variables at comfortable and high speeds were measured using 2D/3D photogrammetry and a floor‐based photocell system. A 3 × 2 ANOVA was used to compare between the groups and 2 time points. The FSA significantly reduced at the comfortable speed by 5.81° for BAR (p < 0.001; Cohen's d = 0.749) and 4.81° for CAD (p = 0.002; Cohen's d = 0.638), and at high speed by 6.54° for BAR (p < 0.001; Cohen's d = 0.753) and by 4.71° for CAD (p = 0.001; Cohen's d = 0.623). The cadence significantly increased by 2% in the CAD group (p = 0.015; Cohen's d = 0.344) at comfortable speed and the BAR group showed a 1.7% increase at high speed. BAR and CAD retraining programs showed a moderate effect for reducing FSA and rearfoot prevalence, and a small effect for increasing cadence. Both offer low‐cost and feasible tools for gait modification within recreational runners in clinical scenarios.
Bifurcations and Arnold Tongues of a Multiplier-Accelerator Model
Authors: Zhong Jiyu 
Published: October 2021

Abstract
In this paper, we investigate the bifurcations of a multiplier-accelerator model with nonlinear investment function in an anticyclical fiscal policy rule. First, we give the conditions that the model produces supercritical flip bifurcation and subcritical one, respectively. Second, we prove that the model undergoes a generalized flip bifurcation and present a parameter region such that the model possesses two two-periodic orbits. Third, it is proved that the model undergoes supercritical Neimark–Sacker bifurcation and produces an attracting invariant circle surrounding a fixed point. Fourth, we present the Arnold tongues such that the model has periodic orbits on the invariant circle produced from the Neimark–Sacker bifurcation. Finally, to verify the correctness of our results, we numerically simulate an attracting two-periodic orbit, a stable invariant circle, an Arnold tongue with rotation number 1/7 and an attracting seven-periodic orbit on the invariant circle.
Probing the explanation of the muon (g-2) anomaly and thermal light dark matter with the semi-visible dark photon channel
Authors: Cazzaniga C. , Odagiu P. , Depero E. , Molina Bueno L. , Andreev Yu. M. , Banerjee D. , Bernhard J. , Burtsev V. E. , Charitonidis N. , Chumakov A. G. , Cooke D. , Crivelli P. , Dermenev A. V. , Donskov S. V. , Dusaev R. R. , Enik T. , Feshchenko A. , Frolov V. N. , Gardikiotis A. , Gerassimov S. G. , Girod S. , Gninenko S. N. , Hösgen M. , Kachanov V. A. , Karneyeu A. E. , Kekelidze G. , Ketzer B. , Kirpichnikov D. V. , Kirsanov M. M. , Kolosov V. N. , Konorov I. V. , Kovalenko S. G. , Kramarenko V. A. , Kravchuk L. V. , Krasnikov N. V. , Kuleshov S. V. , Lyubovitskij V. E. , Lysan V. , Matveev V. A. , Mikhailov Yu. V. , Peshekhonov D. V. , Polyakov V. A. , Radics B. , Rojas R. , Rubbia A. , Samoylenko V. D. , Shchukin D. , Sieber H. , Tikhomirov V. O. , Tlisova I. V. , Tlisov D. A. , Toropin A. N. , Trifonov A. Yu. , Vasilishin B. I. , Arenas G. Vasquez , Volkov P. V. , Volkov V. Yu. , Ulloa P. ,   NA64 Collaboration
Published: October 2021

AbstractWe report the results of a search for a new vector boson ($$ A'$$

A
′

) decaying into two dark matter particles $$\chi _1 \chi _2$$

χ
1

χ
2

of different mass. The heavier $$\chi _2$$

χ
2

particle subsequently decays to $$\chi _1$$

χ
1

and an off-shell Dark Photon $$ A'^* \rightarrow e^+e^-$$

A

′
∗

→

e
+

e
-

. For a sufficiently large mass splitting, this model can explain in terms of new physics the recently confirmed discrepancy observed in the muon anomalous magnetic moment at Fermilab. Remarkably, it also predicts the observed yield of thermal dark matter relic abundance. A detailed Monte-Carlo simulation was used to determine the signal yield and detection efficiency for this channel in the NA64 setup. The results were obtained re-analyzing the previous NA64 searches for an invisible decay $$A'\rightarrow \chi \overline{\chi }$$

A
′

→
χ

χ
¯

and axion-like or pseudo-scalar particles $$a \rightarrow \gamma \gamma $$

a
→
γ
γ

. With this method, we exclude a significant portion of the parameter space justifying the muon g-2 anomaly and being compatible with the observed dark matter relic density for $$A'$$

A
′

masses from 2$$m_e$$

m
e

up to 390 MeV and mixing parameter $$\varepsilon $$
ε
between $$3\times 10^{-5}$$

3
×

10

-
5

and $$2\times 10^{-2}$$

2
×

10

-
2

.
Characterizing partisan political narrative frameworks about COVID-19 on Twitter
Authors: Jing Elise , Ahn Yong-Yeol 
Published: October 2021

AbstractThe COVID-19 pandemic is a global crisis that has been testing every society and exposing the critical role of local politics in crisis response. In the United States, there has been a strong partisan divide between the Democratic and Republican party’s narratives about the pandemic which resulted in polarization of individual behaviors and divergent policy adoption across regions. As shown in this case, as well as in most major social issues, strongly polarized narrative frameworks facilitate such narratives. To understand polarization and other social chasms, it is critical to dissect these diverging narratives. Here, taking the Democratic and Republican political social media posts about the pandemic as a case study, we demonstrate that a combination of computational methods can provide useful insights into the different contexts, framing, and characters and relationships that construct their narrative frameworks which individual posts source from. Leveraging a dataset of tweets from the politicians in the U.S., including the ex-president, members of Congress, and state governors, we found that the Democrats’ narrative tends to be more concerned with the pandemic as well as financial and social support, while the Republicans discuss more about other political entities such as China. We then perform an automatic framing analysis to characterize the ways in which they frame their narratives, where we found that the Democrats emphasize the government’s role in responding to the pandemic, and the Republicans emphasize the roles of individuals and support for small businesses. Finally, we present a semantic role analysis that uncovers the important characters and relationships in their narratives as well as how they facilitate a membership categorization process. Our findings concretely expose the gaps in the “elusive consensus” between the two parties. Our methodologies may be applied to computationally study narratives in various domains.