bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty acid homeostasis in honey bees (Apis mellifera) fed commercial diet supplements
Authors: Corby-Harris Vanessa , Bennett Meghan M. , Deeter Megan E. , Snyder Lucy , Meador Charlotte , Welchert Ashley C. , Hoffman Amelia , Obernesser Bethany T. , Carroll Mark J. 
Published: December 2021

AbstractHoney bees obtain lipids from pollen or commercial supplements. These supplements do not fully support colony health. We tested the hypothesis that supplements are deficient because they lack essential fatty acids (EFAs). The five supplements we tested had low linolenic (⍵3) acid and were unbalanced (⍵6:⍵3 > 6) compared to natural pollen. We selected two of these supplements for further study because they had different levels of individual EFAs and different ⍵6:⍵3 ratios. Bees from hives fed these different supplements had equivalent tissue EFA levels. In choice assays, hives fed these different supplements were presented with flours with various absolute and relative levels of EFAs. We saw no difference in foraging preference. Rather, all hives preferred flours with small grain size and high protein to lipid ratios. We conclude that bees balance their internal EFAs and that differential colony nutrition does not affect foraging preference. The data also argue for more linolenic (⍵3) acid in commercial supplements.
Responsible innovation for digital identity systems
Authors: Anand Nishant , Brass Irina 
Published: December 2021

Abstract
Digital identity (eID) systems are a crucial piece in the digital services ecosystem. They connect individuals to a variety of socioeconomic opportunities but can also reinforce power asymmetries between organizations and individuals. Data collection practices can negatively impact an individual’s right to privacy, autonomy, and self-determination. Protecting individual rights, however, may be at odds with imperatives of profit maximization or national security. The use of eID technologies is hence highly contested. Current approaches to governing eID systems have been unable to fully address the trade-offs between the opportunities and risks associated with these systems. The responsible innovation (RI) literature provides a set of principles to govern disruptive innovations, such as eID systems, toward societally desirable outcomes. This article uses RI principles to develop a framework to govern eID systems in a more inclusive, responsible, and user-centered manner. The proposed framework seeks to complement existing practices for eID system governance by bringing forth principles of deliberation and democratic engagement to build trust amongst stakeholders of the eID system and deliver shared socioeconomic benefits.
Maximizing the Role of Emergency Medical Services in COVID-19 Response
Authors: Sonkin Roman , Alpert Evan Avraham , Katz David E. , Jaffe Eli 
Published: December 2021

Abstract
The Centers for Disease Control and Prevention define 6 intervals of a pandemic: (1) investigation of cases, (2) recognition of the increased potential for ongoing transmission, (3) initiation of a pandemic wave, (4) acceleration of a pandemic wave, (5) deceleration of a pandemic wave, and (6) preparation for future pandemic waves. Each of these stages has 8 domains. Following China’s coronavirus disease 2019 (COVID-19) outbreak announcement, Israel’s National Emergency Medical Services (EMS) Organization immediately began working in conjunction with the Ministry of Health (MOH) to address the threat of the COVID-19 outbreak. This article will describe how a national EMS organization acted according to these pandemic intervals and domains. In the initial stages, EMS managed a checkpoint in the international airport voluntarily testing people for febrile symptoms. Calls to the dispatch centers that aroused the suspicion of COVID-19 resulted in EMS transport to the hospital with protective gear. During the period of first exposure, the scope of the medical emergency number was increased to include questions concerning coronavirus, telemedicine, and home sampling by protected EMS workers. In the contagion stages, epidemiological tests were conducted by the MOH, and EMS began operating dedicated telephone triage, mass drive-through sampling, and finally, administration of vaccinations.
Towards the development of an automated electrical self-potential sensor of melt and rainwater flow in snow
Authors: Priestley Alex , Kulessa Bernd , Essery Richard , Lejeune Yves , Le Gac Erwan , Blackford Jane 
Published: December 2021

AbstractTo understand snow structure and snowmelt timing, information about flows of liquid water within the snowpack is essential. Models can make predictions using explicit representations of physical processes, or through parameterization, but it is difficult to verify simulations. In situ observations generally measure bulk quantities. Where internal snowpack measurements are made, they tend to be destructive and unsuitable for continuous monitoring. Here, we present a novel method for in situ monitoring of water flow in seasonal snow using the electrical self-potential (SP) geophysical method. A prototype geophysical array was installed at Col de Porte (France) in October 2018. Snow hydrological and meteorological observations were also collected. Results for two periods of hydrological interest during winter 2018–19 (a marked period of diurnal melting and refreezing, and a rain-on-snow event) show that the electrical SP method is sensitive to internal water flow. Water flow was detected by SP signals before it was measured in conventional snowmelt lysimeters at the base of the snowpack. This initial feasibility study shows the utility of the SP method as a non-destructive snow sensor. Future development should include combining SP measurements with a high-resolution snow physics model to improve prediction of melt timing.
Peripheral inflammatory markers associated with brain volume reduction in patients with bipolar I disorder
Authors: Tsai Shang-Ying , Sajatovic Martha , Hsu Jung-Lung , Chung Kuo-Hsuan , Chen Pao-Huan , Huang Yu-Jui 
Published: December 2021

AbstractBackground:Neuroinflammation and brain structural abnormalities are found in bipolar disorder (BD). Elevated levels of cytokines and chemokines have been detected in the serum and cerebrospinal fluid of patients with BD. This study investigated the association between peripheral inflammatory markers and brain subregion volumes in BD patients.Methods:Euthymic patients with bipolar I disorder (BD-I) aged 20–45 years underwent whole-brain magnetic resonance imaging. Plasma levels of monocyte chemoattractant protein-1 (MCP-1), chitinase-3-like protein 1 (also known as YKL-40), fractalkine (FKN), soluble tumour necrosis factor receptor-1 (sTNF-R1), interleukin-1β, and transforming growth factor-β1 were measured on the day of neuroimaging. Clinical data were obtained from medical records and interviewing patients and reliable others.Results:We recruited 31 patients with a mean age of 29.5 years. In multivariate regression analysis, plasma level YKL-40, a chemokine, was the most common inflammatory marker among these measurements displaying significantly negative association with the volume of various brain subareas across the frontal, temporal, and parietal lobes. Higher YKL-40 and sTNF-R1 levels were both significantly associated with lower volumes of the left anterior cingulum, left frontal lobe, right superior temporal gyrus, and supramarginal gyrus. A greater number of total lifetime mood episodes were also associated with smaller volumes of the right caudate nucleus and bilateral frontal lobes.Conclusions:The volume of brain regions known to be relevant to BD-I may be diminished in relation to higher plasma level of YKL-40, sTNF-R1, and more lifetime mood episodes. Macrophage and macrophage-like cells may be involved in brain volume reduction among BD-I patients.
Changes in serum levels of brain-derived neurotrophic factor with electroconvulsive therapy and pharmacotherapy and its clinical correlates in male schizophrenia patients
Authors: Akbas Ibrahim , Balaban Ozlem Devrim 
Published: December 2021

AbstractObjectives:It has been postulated that neurotrophin dysregulation leads to disorganisation in neuronal networks, which results in schizophrenia. The current study sets out to evaluate if the finding of lower brain-derived neurotrophic factor (BDNF) levels in schizophrenia patients could be confirmed in an independent cohort and to investigate if the BDNF levels can be altered with different treatment modalities such as electroconvulsive therapy (ECT) and/or antipsychotic pharmacotherapy (PT).Methods:A total of 54 male patients with schizophrenia and 35 healthy controls were included in the study. Schizophrenia patients were subdivided into two groups as the ones who underwent ECT + PT and only PT. Clinical and sociodemographic data questionnaire, Positive and Negative Syndrome Scale (PANSS) and blood sample collection for BDNF assessment were applied to all patients (on first and last days of admissions) and healthy participants (on the day of the interview). Then, clinical parameters and blood sample outcomes were statistically analysed.Results:Mean BDNF levels of healthy individuals were significantly higher than mean pre- and post-treatment BDNF levels in both PT only and ECT + PT groups. While serum BDNF levels did not increase after ECT + PT, there was a trend level increase in the PT only group. There was no significant correlation between the changes in serum BDNF levels with total PANSS scores in either group after treatment.Conclusions:We could confirm previously suggested data of lower serum BDNF levels in schizophrenia patients compared to healthy population but we could not find significant increase in serum BDNF levels with ECT + PT or only PT as some previous studies suggested.
Reconstituted virus–nucleus system reveals mechanics of herpesvirus genome uncoating
Authors: Evilevitch Alex , Tsimtsirakis Efthymios 
Published: December 2021

AbstractThe viral replication cycle is controlled by information transduced through both molecular and mechanical interactions. Viral infection mechanics remains largely unexplored, however, due to the complexity of cellular mechanical responses over the course of infection as well as a limited ability to isolate and probe these responses. Here, we develop an experimental system consisting of herpes simplex virus type 1 (HSV-1) capsids bound to isolated and reconstituted cell nuclei, which allows direct probing of capsid–nucleus mechanics with atomic force microscopy (AFM). Major mechanical transformations occur in the host nucleus when pressurised viral DNA ejects from HSV-1 capsids docked at the nuclear pore complexes (NPCs) on the nuclear membrane. This leads to structural rearrangement of the host chromosome, affecting its compaction. This in turn regulates viral genome replication and transcription dynamics as well as the decision between a lytic or latent course of infection. AFM probing of our reconstituted capsid–nucleus system provides high-resolution topographical imaging of viral capsid docking at the NPCs as well as force volume mapping of the infected nucleus surface, reflecting mechanical transformations associated with chromatin compaction and stiffness of nuclear lamina (to which chromatin is tethered). This experimental system provides a novel platform for investigation of virus–host interaction mechanics during viral genome penetration into the nucleus.
Trends and predictors of early initiation, exclusive and continued breast-feeding in Bangladesh (2004–2018): a multilevel analysis of demographic and health survey data
Authors: Ahmed Md. Sabbir , Whitfield Kyly C. , Yunus Fakir Md 
Published: December 2021

AbstractThe early initiation of breast-feeding (EIBF) within 1 h of birth, exclusive breast-feeding (EBF) to 6 months and continued breast-feeding (CBF) to 2 years are key infant and young child feeding guidelines promoted globally for optimal child health and development. Using publicly available national survey data from the five most recent, consecutive Bangladesh Demographic and Health Surveys (2004, 2007, 2011, 2014 and 2017–2018), we assessed the trends in these key breast-feeding indicators. Multiple multilevel logistic regression models were built to assess socio-demographic predictors of breast-feeding using the latest 2017–2018 data set. Both EIBF and EBF have increased significantly between 2004 and 2017–2018, from 26 % to 60 % and 36 % to 68 %, respectively, and CBF decreased from 94 % to 85 %. Caesarean section delivery conferred lower EIBF practice (OR = 0·34, 95 % CI 0·27, 0·42) compared with vaginal delivery. Women who were currently working had 32 % lower odds of EBF (OR = 0·68, 95 % CI 0·48, 0·95). Compared with delivery at home, women who delivered in a health facility had 81 % higher odds of EBF (OR = 1·81, 95 % CI 1·25, 2·34). Larger family size (≥5) also predicted EBF (OR = 1·70, 95 % CI 1·21, 2·40). Rural residency was associated with 2·39 (95 % CI 1·32, 4·31) times of higher odds of CBF. Regional variation was also predictive of the various breast-feeding indicators. Although Bangladesh currently exceeds the 2019 global prevalence rates for these three breast-feeding indicators, efforts should be made to continue improving EIBF and EBF and to prevent future decreases in CBF.
Why we should be looking for earlobe creases in ENT. A systematic review and meta-analysis of diagonal earlobe crease and coronary artery disease
Authors: Curtis J , Walford S 
Published: December 2021

Abstract

Objective
The association between diagonal earlobe crease and cardiovascular disease has been known for several decades. This review investigated whether there is a significant association between the presence of a diagonal earlobe crease and coronary artery disease independent of other confounding factors.

Method
This study was a systematic review and meta-analysis of selected studies using the Preferred Reporting Items for Systematic Reviews and Meta-analyses checklist.

Results
This study included 12 studies in the pooled analysis with 2415 cases and 2545 controls. The study found that patients with diagonal earlobe crease have an increased (four times) likelihood of having coronary artery disease. In addition, despite some previous studies suggesting that diagonal earlobe crease was simply a result of age, all 10 of the included studies that looked at this found that the relationship between diagonal earlobe crease and coronary artery disease was independent of both age and other known cardiovascular risk factors.

Conclusion
Patients with diagonal earlobe crease appear to have an increased risk of coronary artery disease, and this may be higher for patients with bilateral diagonal earlobe crease.
Histopathological changes of nasal mucosa after nasal packing with Merocel
Authors: Tan M , Bayındır T , Çiçek M T , Aslan M , Gül M 
Published: December 2021

AbstractObjectiveTo determine histopathological changes in nasal mucosa associated with duration of nasal packing with Merocel tampons.MethodsThis study included 24 healthy rabbits, 6 rabbits per group. In group A, no tampon was applied. In group B, Merocel nasal tampons were applied and removed after 24 hours. In group C, the tampons were removed after 48 hours. In group D, the tampons were removed after 5 days. Specimens were obtained from the septum of each rabbit, including cartilage. Histopathological examination was performed.ResultsSignificant differences were observed in terms of inflammatory infiltration and loss of cilia between groups A and B. Significant differences were also observed in terms of inflammatory infiltration, haematoma, cilia loss, epithelium dysplasia and cartilage degeneration between groups B and C. There were significant differences in terms of cilia loss, epithelium dysplasia and subepithelial fibrosis between groups C and D. Cartilage degeneration was mild in one animal in group B and in two animals in group C, and was moderate in four animals in group C.ConclusionIt is recommended that Merocel nasal tampons are removed within 48 hours to preserve nasal mucosal function. Keeping the pack longer may cause cartilage degeneration and other complications.
The Street-Level Organisation in-between Employer Needs and Client Needs: Creaming Users by Motivation in the Norwegian Employment and Welfare Service (NAV)
Authors: GJERSØE HEIDI MOEN , STRAND ANNE HEGE 
Published: December 2021

AbstractEmployer engagement is increasingly emphasised in the context of efforts to bring more disadvantaged people into work. A new approach in the Norwegian Employment and Welfare Service (NAV) combines demand-side and supply-side measures in a ‘combined workplace-oriented approach’. Through qualitative interviews with frontline staff – including job coaches following the Supported Employment (SE) method – the paper examines the intermediary role of the street-level organisation (SLO) through the targeted use of SE methods directed at young users and employers. The findings suggest that young users are ‘creamed by motivation’ into the SE programme, which can be explained by the importance the SLO places: on maintaining inter-organisational relationships with employers, on job coaches’ performance goals and the need to uphold an organisational structure in the SLO that seemingly works efficient to shift caseloads of young unemployed into work. Hence, creaming is not specific to outsourcing but can also occur when insourcing employer engagement services into a public SLO. Although relational work directed at both employers and young clients is seen as the benefit of a combined workplace-oriented approach, it appears a rather flimsy foundation for successful ALMPs unless supported by more structural demand-side measures.
Asymptotics of sloshing eigenvalues for a triangular prism
Authors: MAYRAND JULIEN , SENÉCAL CHARLES , ST–AMANT SIMON 
Published: December 2021

AbstractWe consider the three-dimensional sloshing problem on a triangular prism whose angles with the sloshing surface are of the form
${\pi}/{2q}$
, where q is an integer. We are interested in finding a two-term asymptotic expansion of the eigenvalue counting function. When both angles are
${\pi}/{4}$
, we compute the exact value of the second term. As for the general case, we conjecture an asymptotic expansion by constructing quasimodes for the problem and computing the counting function of the related quasi-eigenvalues. These quasimodes come from solutions of the sloping beach problem and correspond to two kinds of waves, edge waves and surface waves. We show that the quasi-eigenvalues are exponentially close to real eigenvalues of the sloshing problem. The asymptotic expansion of their counting function is closely related to a lattice counting problem inside a perturbed ellipse where the perturbation is in a sense random. The contribution of the angles can then be detected through that perturbation.
Identifying Primary Care Models of Dementia Care that Improve Quality of Life for People Living with Dementia and their Care Partners: An Environmental Scan
Authors: Helmer-Smith Mary , Mihan Ariana , Sethuram Claire , Moroz Isabella , Crowe Lois , MacDonald Tanya , Major Jennifer , Houghton Deanne , Laplante James , Mastin Donald , Poole Lisa , Wighton Mary Beth , Liddy Clare 
Published: December 2021

AbstractDementia is a growing concern in Canada, affecting peoples’ health and raising the cost of care. Between June and October 2019, we conducted an environmental scan to identify primary care models, strategies, and resources for dementia care from 11 pre-selected countries and assess their impact on quality-of-life measures. Search strategies included a rapid scoping review, grey literature search, and discussions with stakeholders. Eighteen primary care-based models of dementia care were identified. Common factors include team-based care, centralized care/case coordination, individual treatment plans, a stepped-care approach, and support for care partners. Five provinces had released a dementia strategy. Evidence of positive outcomes supported primary care-based models for dementia care, although only one model demonstrated evidence of impact on quality of life. Although these findings are encouraging, further research is needed to identify primary care-based models of dementia care that demonstrably improve quality of life for people living with dementia and their care partners.
Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing
Authors: Puetz V. B. , Viding E. , Maguire E. A. , Mechelli A. , Armbruster-Genç D. , Sharp M. , Rankin G. , Gerin M. I. , McCrory E. J. 
Published: December 2021

AbstractAltered autobiographical memory (ABM) processing characterizes some individuals with experiences of childhood maltreatment. This fMRI study of ABM processing evaluated potential developmental plasticity in neural functioning following maltreatment. Adolescents with (N = 19; MT group) and without (N = 18; Non-MT group) documented childhood maltreatment recalled specific ABMs in response to emotionally valenced cue words during fMRI at baseline (age 12.71 ± 1.48) and follow-up (14.88 ± 1.53 years). Psychological assessments were collected at both timepoints. Longitudinal analyses were carried out with BOLD signal changes during ABM recall and psychopathology to investigate change over time. In both groups there was relative stability of the ABM brain network, with some developmental maturational changes observed in cortical midline structures (ventromedial PFC (vmPFC), posterior cingulate cortex (pCC), and retrosplenial cortex (rSC). Significantly increased activation of the right rSC was observed only in the MT group, which was associated with improved psychological functioning. Baseline group differences in relation to hippocampal functioning, were not detected at follow-up. This study provides preliminary empirical evidence of functional developmental plasticity in children with documented maltreatment experience using fMRI. This suggests that altered patterns of brain function, associated with maltreatment experience, are not fixed and may reflect the potential to track a neural basis of resilience.
Risk factors for early use of e-cigarettes and alcohol: Dimensions and profiles of temperament
Authors: Hartmann Sarah A. , Hayes Timothy , Sutherland Matthew T. , Trucco Elisa M. 
Published: December 2021

AbstractAdolescent e-cigarette use has been labeled an epidemic and alcohol use during this developmental period is associated with deleterious outcomes. Though specific temperamental dimensions have been shown to predict substance use, profiles of temperament have rarely been examined as predictors. This study examines dimensions and profiles of adolescent temperament as predictors of early use of e-cigarettes and alcohol. The sample was comprised of adolescent (62.07% female, 87.59% White, 82.76% Hispanic/Latinx)/caregiver dyads (N = 146) who completed the first two timepoints (M age at second timepoint = 16.16, SD = 0.68) of a longitudinal adolescent substance use study. Models showed parent-reported effortful control predicted protection against adolescent use of e-cigarettes, whereas adolescent report of effortful control predicted protection against alcohol use. Though dissimilar in temperamental pattern, three profiles emerged from both parent- and adolescent-report-based latent profile analysis models. Adolescents characterized by parents as displaying a Resilient profile had greater odds of e-cigarette use than those characterized by a Reserved profile, whereas adolescents who self-characterized as Mixed-type had markedly greater odds of alcohol use than those who self-characterized as Resilient. Utilization of temperamental profiles may aid in identification of particularly vulnerable subgroups of adolescents who may benefit from relevant preventative programing.