bluuebunny/crossref_metadata_2025_split huggingface dataset:
Report of the 22nd nationwide follow‐up Survey of Primary Liver Cancer in Japan (2012–2013)
Authors: Kudo Masatoshi , Izumi Namiki , Kokudo Norihiro , Sakamoto Michiie , Shiina Shuichiro , Takayama Tadatoshi , Tateishi Ryosuke , Nakashima Osamu , Murakami Takamichi , Matsuyama Yutaka , Takahashi Arata , Miyata Hiroaki , Kubo Shoji 
Published: May 2021

AbstractIn the 22nd Nationwide Follow‐up Survey of Primary Liver Cancer in Japan, data from 21 155 newly registered patients and 43 041 previously registered follow‐up patients were compiled from 538 institutions over a 2‐year period from January 1, 2012 to December 31, 2013. Basic statistics compiled for patients newly registered in the 22nd survey were cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment‐related factors, pathologic diagnosis, recurrence status and autopsy findings. Compared with the previous 21st survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, more patients with non‐B non‐C HCC, smaller tumor diameter and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma, and combined hepatocellular cholangiocarcinoma (combined HCC and intrahepatic cholangiocarcinoma) by treatment type and background characteristics for patients newly registered between 2002 and 2013 whose final outcome was survival or death. Median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter or Child–Pugh grade) and by treatment type (hepatectomy, radiofrequency ablation therapy, transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2013 into five time period groups. The data obtained from this nationwide follow‐up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer worldwide.
User involvement in the making: Positions and types of knowledge enacted in the interaction between service users and researchers in user panel meetings
Authors: Koren Solvang Per , Sveen Unni , Søberg Helene Lundgaard 
Published: May 2021

AbstractBackgroundNumerous studies of user involvement in research have been conducted. However, there is a lack of studies applying observational methods and addressing the concrete practice of involvement.ObjectiveTo determine what knowledge types and competences users apply when involved in the research process through user panel meetings.DesignUser panel meetings in a qualitative project in rehabilitation were sound‐recorded and transcribed verbatim. Data analysis applied an abductive approach framed by positioning theory.Setting and participantsSix rehabilitation service users and a similar number of researchers met 20 times during a six‐year project period. They discussed various issues in the research process such as interview guides, analysis and dissemination of results.FindingsThe service users combined their respective knowledge and competence into six positions enacted in the panel interactions. They engaged as co‐researchers, based their contributions on their respective personal histories, represented an NGO and peers, applied their respective professional and educational backgrounds and, finally, engaged as concerned citizens.Discussion and conclusionThe findings add to the discussion of professionalization of user involvement by introducing a wider array of positions enacted than do the findings of previous studies. Researchers recruiting user panel members, as well as NGOs appointing candidates for user panels, are advised to consider a wide competence profile for possible candidates. A panel is also considered as a resource in confirming and elaborating on a study's findings.Patient and public contributionA service user panel contributed to the study.
Health literacy: The role of NHS library and knowledge services
Authors: Naughton Joanne , Booth Kerry , Elliott Paula , Evans Morag , Simões Maria , Wilson Suzanne 
Published: May 2021

AbstractHealth literacy is key to person‐centred, preventative healthcare and is both a societal and individual responsibility. This feature describes work undertaken by Health Education England, the Community Health and Learning Foundation and NHS Library and Knowledge Services to raise awareness among NHS staff and other key partners of the impact of low health literacy. It highlights a range of health literacy resources and ideas for developing and adapting these tools for remote delivery during and post‐pandemic.D.I.
Expanding conceptual understanding of interview anxiety and performance: Integrating cognitive, behavioral, and physiological features
Authors: Constantin Kaytlin L. , Powell Deborah M. , McCarthy Julie M. 
Published: May 2021

AbstractInterview anxiety is common among interviewees and has the potential to undermine an applicant's interview performance. Nevertheless, there is much that we do not understand about the role of anxiety in job interviews. In this paper, we advance a conceptual model that highlights the multidimensional nature of interview anxiety by incorporating its cognitive, behavioral, and physiological components, termed the Tripartite Interview Anxiety Framework (TIAF). This model highlights the role of person, interviewer, and contextual characteristics in shaping interview anxiety, elucidates the underlying relations between interview anxiety and performance, and delineates critical moderators of these important relations. In doing so, the TIAF simultaneously advances the theory of interview anxiety, promotes further work in this area, and highlights implications for practice.
“I am making good money, but …”: The precarious situation of Polish nurses in Norway
Authors: Goździak Elżbieta M. , Main Izabella 
Published: May 2021

AbstractPrecarity is defined as precarious existence, lacking in predictability, job security, material or psychological welfare. In migration studies, precarity is often associated with low wages, “illegality” and “deportability.” Based on field research, this article focuses on Polish nurses working in Norway. As health professionals and citizens of the European Union, they do not possess the stereotypical characteristics of precarious workers. They are neither low skilled or poorly compensated nor unauthorised. Our findings emphasise multiple sources of Polish nurses’ precarity in Poland – multiple low‐wage jobs, poor life‐work balance – and in Norway – short‐time assignments, variable working hours, high levels of mobility and challenges in family reunification. Precarity in Norway stemmed from policies that left recruitment of foreign‐born nurses in the hands of private agencies acting without an oversight of the Norwegian Health Directorate. Norway subscribes to the WHO ethical recruitment principles, but it falls short in monitoring private recruitment agencies.
Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre‐ and post‐bright light therapy: First explorations
Authors: Hamers Pauline C. M. , Savas Mesut , van Rossum Elisabeth F. C. , de Rijke Yolanda B. , Bindels Patrick J. E. , Festen Dederieke A. M. , Hermans Heidi 
Published: May 2021

AbstractBackgroundDepressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long‐term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids.MethodScalp hair samples (n = 14) were retrospectively examined at baseline and post‐BLT (10.000 and 300 lux). Liquid chromatography–tandem mass spectrometry was used to measure hair glucocorticoids.ResultsA significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post‐intervention HairE levels were significantly increased ([95% CI: 11.2–17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0–18.3 pg/mg], p = .020).ConclusionsThis study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.
GLCCI1 reduces collagen deposition and airway hyper‐responsiveness in a mouse asthma model through binding with WD repeat domain 45B
Authors: Xun Qiufen , Kuang Jiulong , Yang Qing , Wang Wei , Zhu Guofeng 
Published: May 2021

AbstractAsthma is a serious public health problem worldwide, without effective therapeutic methods. Our previous study indicated that glucocorticoid‐induced transcript 1 gene (GLCCI1) knockout reduces the sensitivity to glucocorticoid in asthmatic mouse. Here, we explored the role and action mechanism of GLCCI1 in asthma development. In ovalbumin‐sensitized mice, airway resistance and tissue damage increased, the production of inflammatory cytokines were up‐regulated, GLCCI1 expression was reduced and autophagy was activated. Increasing of GLCCI1 inhibited human and mouse airway epithelial cell (AEC) autophagy, while decreasing of GLCCI1 promoted autophagy. Furthermore, we found that GLCCI1 bound with WD repeat domain 45B (WDR45B) and inhibited its expression. Increasing of WDR45B partly reversed the inhibition of GLCCI1 to autophagy‐related proteins expression and autophagosome formation in vitro. Increasing of WDR45B in vivo reversed the improvement of GLCCI1 on airway remodelling in asthma and the inhibition to autophagy level in lung tissues. Overall, our data showed that GLCCI1 improved airway remodelling in ovalbumin‐sensitized mice through inhibiting autophagy via combination with WDR45B and inhibiting its expression. Our results proved a new idea for asthma treatment.
Movement ecology of black marlin Istiompax indica in the Western Indian Ocean
Authors: Rohner Christoph A. , Bealey Roy , Fulanda Bernerd M. , Everett Jason D. , Richardson Anthony J. , Pierce Simon J. 
Published: May 2021

AbstractThe black marlin Istiompax indica is an apex marine predator and is susceptible to overfishing. The movement ecology of the species remains poorly known, particularly within the Indian Ocean, which has hampered assessment of their conservation status and fisheries management requirements. Here, we used pop‐up archival satellite tags to track I. indica movement and examine their dispersal. Forty‐nine tags were deployed off Kenya during both the north‐east (November–April) and south‐west (August–September) monsoon seasons, providing locations from every month of the year. Individual I. indica were highly mobile and track distance correlated with the duration of tag attachment. Mean track duration was 38 days and mean track distance was >1800 km. Individuals dispersed in several directions: north‐east into Somalian waters and up to northern Oman, east towards the Seychelles, and south into the Mozambique Channel. Their core habitat shifted seasonally and overlapped with areas of high productivity off Kenya, Somalia and Oman during the first half of the year. A second annual aggregation off the Kenyan coast, during August and September, did not coincide with high chlorophyll‐a (chl‐a) concentrations or thermal fronts, and the drivers of the species' presence and movement from this second aggregation was unclear. We tested their habitat preferences by comparing environmental conditions at track locations to the conditions at locations along simulated tracks based on the empirical data. Observed I. indica preferred cooler water with higher chl‐a concentrations and stayed closer to the coast than simulated tracks. The rapid and extensive dispersal of I. indica from Kenya suggests that there is likely a single stock in the Western Indian Ocean, with individuals swimming between areas of high commercial catches off northern Somalia and Oman, and artisanal and recreational fisheries catches throughout East Africa and Mozambique.
Rapid re‐transplantation safety following early kidney graft loss
Authors: Rodríguez‐Espinosa Diana , Broseta José Jesús , Hermida Evelyn , Cuadrado Elena , Guillén‐Olmos Elena , Montagud‐Marrahi Enrique , Diekmann Fritz 
Published: May 2021

AbstractIntroductionEarly graft loss is a devastating kidney transplant complication associated with high mortality and an increased risk of sensitization to antigens from the failed graft. Moreover, if rapid re‐transplantation were to occur, given that the human leukocyte antigen antibodies identification may not be reliable until several weeks after transplantation, the recipient's immunological status would be uncertain. Hence, there could be an increased immunological risk. To date, there is no information on whether a rapid re‐transplantation after early graft loss, without a new reliable anti‐HLA determination, is safe.MethodsWe retrospectively analysed the number of rejections and the graft survival of re‐transplanted patients with early graft loss (defined as graft failure before 30 days from transplant) from our centre between June 2003 and November 2019. The studied population was divided into rapid re‐transplantation (performed within 30 days of early graft loss) and late re‐transplantation (performed beyond those 30 days).ResultsForty‐seven patients were re‐transplanted after early graft loss. There were nine rapid re‐transplantation cases with an 89% five‐year graft survival and one antibody‐mediated rejection episode. Furthermore, we identified 38 cases of late re‐transplantation with a 69% five‐year graft survival, 4 T cell‐mediated, and 11 antibody‐mediated rejections.ConclusionsRapid re‐transplantation appears to be safe and does not entail increased rejection risk, nor does it impact long‐term graft survival when compared to late re‐transplantation.
Tapentadol results in less deterioration of gastrointestinal function and symptoms than standard opioid therapy in healthy male volunteers
Authors: Mark Esben Bolvig , Nedergaard Rasmus Bach , Hansen Tine Maria , Nissen Thomas Dahl , Frøkjær Jens Brøndum , Scott S. Mark , Krogh Klaus , Drewes Asbjørn Mohr 
Published: May 2021

AbstractBackgroundTapentadol is a combined opioid agonist and norepinephrine reuptake inhibitor with fewer gastrointestinal side effects at equianalgesic doses compared with classical strong opioids. Previous studies on tapentadol have included multi‐morbid patients in whom confounders exclude detailed assessment of the mechanistic effects and strict comparison with other opioids or placebo. This study aimed at investigating the effects of tapentadol and oxycodone on gastrointestinal motility and gastrointestinal side effects.Methods21 healthy males participated in a randomized, double‐blind, placebo‐controlled, crossover study. Tapentadol (50 mg twice daily), oxycodone (10 mg twice daily), or placebo tablets were administered for 14 days. Segmental gastrointestinal transit times and colonic motility parameters were measured with electromagnetic capsules. Gastrointestinal side effects were assessed using questionnaires.Key ResultsDuring dosing with tapentadol, gastrointestinal side effects and motility parameters were on placebo level. Compared with tapentadol, oxycodone increased whole gut transit time by 17.9 hours (p = .015) and rectosigmoid transit time by 6.5 hours (p = .005). Compared with tapentadol, oxycodone also reduced long, fast antegrade colonic movements (p = .001). In comparison with placebo, oxycodone prolonged whole gut transit time by 31.6 hours, (p < .001). Moreover, less long, fast antegrade colonic movements (p = .002) were observed during oxycodone. For oxycodone only, slow colonic movements were associated with gastrointestinal side effects.Conclusions & InferencesIn this mechanistic study, tapentadol caused significantly less colonic dysmotility and gastrointestinal side effects as compared with oxycodone in equianalgesic doses.
Street‐level bureaucrats and policy entrepreneurship: When implementers challenge policy design
Authors: Cohen Nissim , Aviram Neomi F. 
Published: May 2021

AbstractLinking street‐level bureaucracy with policy entrepreneurship is a new, ongoing trend in the literature. We claim that in various cases one must consider street‐level policy entrepreneurship in order to fully understand policy processes. Therefore, we call on public policy and administration scholars to devote more resources to this important link. The symposium will promote our understanding of this still underresearched area. We will explore both theoretically and empirically how bureaucrats who interact with the public on a daily basis not only implement policy but also influence how it is designed. We will also assess the contribution of the symposium papers in light of the existing scholarly debate. We will conclude by reflecting on the challenges of studying street‐level policy entrepreneurship and suggest future avenues for research in this field.
The plasma membrane–associated Ca2+‐binding protein,PCaP1,is required for oligogalacturonide and flagellin‐induced priming and immunity
Authors: Giovannoni Moira , Marti Lucia , Ferrari Simone , Tanaka‐Takada Natsuki , Maeshima Masayoshi , Ott Thomas , De Lorenzo Giulia , Mattei Benedetta 
Published: May 2021

AbstractEarly signalling events in response to elicitation include reversible protein phosphorylation and re‐localization of plasma membrane (PM) proteins. Oligogalacturonides (OGs) are a class of damage‐associated molecular patterns (DAMPs) that act as endogenous signals to activate the plant immune response. Previous data on early phosphoproteome changes inArabidopsis thalianaupon OG perception uncovered the immune‐related phospho‐regulation of several membrane proteins, among which PCaP1, a PM‐anchored protein with actin filament–severing activity, was chosen for its potential involvement in OG‐ and flagellin‐triggered responses. Here, we demonstrate that PCaP1 is required for late, but not early, responses induced by OGs and flagellin. Moreover,pcap1mutants, unlike the wild type, are impaired in the recovery of full responsiveness to a second treatment with OGs performed 24 h after the first one. Localization studies on PCaP1 upon OG treatment in plants expressing a functional PCaP1‐GFP fusion under the control ofPCaP1promoter revealed fluorescence on the PM, organized in densely packed punctate structures, previously reported as microdomains. Fluorescence was found to be associated also with endocytic vesicles, the number of which rapidly increased after OG treatment, suggesting both an endocytic turnover of PCaP1 for maintaining its homeostasis at the PM and an OG‐induced endocytosis.
Forest soil penetration resistance following heavy traffic: A 10‐year field study
Authors: Pousse Noémie , Bonnaud Pascal , Legout Arnaud , Darboux Frédéric , Ranger Jacques 
Published: May 2021

AbstractNatural recovery of acidic soils following heavy traffic is assumed to take several decades. The aim of this study was to monitor the recovery of soil penetration resistance (PR) after soil compaction by heavy traffic at two forest sites. The sites, located in northeast France, have soils that differ slightly in pH and silt content. The impact on soil PR following heavy traffic was dependent on the soil water content (WC) at the time of measurement, and, therefore, the entire WC range and corresponding PR values were measured. For the most acidic and silty soil, no difference in PR among treatments was observed when the soils were near saturation; however, the difference in PR values was high when soils were close to wilting point. For the least acidic and silty soil, the impact of heavy traffic on PR could be detected whatever the soil moisture, with the magnitude of the effect dependent on the soil water content and depth considered. Standardized PR values with regard to WC allowed an analysis of the evolution of the effect of heavy traffic with time. Ten years after being subjected to heavy traffic, the PR values in the 0‐ to 40‐cm layer recovered to undisturbed values at the least acidic and silty site, but not WC dynamic. The most acidic and silty soil site did not show any recovery of PR or WC dynamic ten years following traffic, although liming at this site was able to increase the regeneration of PR to undisturbed levels.
Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population
Authors: Yang Jia , Liu Weipeng , Yan Zhiling , Li Chuanyin , Liu Shuyuan , Yang Xi , Li Yu , Shi Li , Yao Yufeng 
Published: May 2021

The host immune system plays an important role in infectious diseases and cancers. The heterodimer formed by transporter associated with antigen presenting (TAP)1 and TAP2 is responsible for intracellular peptide loading onto MHC‐I molecules. Studies have shown that single‐nucleotide polymorphisms (SNPs) in TAP genes might affect the expression and function of TAP and be associated with cancer risk. We aimed to investigate the association of SNPs in the TAP1 and TAP2 genes with cervical intraepithelial neoplasia (CIN) and cervical cancer (CC) in a Chinese Han population. Six SNPs in the TAP1 gene and seven in the TAP2 gene were selected. The 13 SNPs were genotyped in 1255 healthy individuals, 575 patients with CIN and 1034 patients with CC using the SNaPshot assay. The association between these SNPs and CIN and CC risk was analysed. The allelic and genotypic distributions of rs41549617 and rs1135216 showed significant differences between the control and CC groups (P < 0.0038). The T allele of rs41549617 was associated with a decreased risk of CC (OR = 0.476, 95%CI: 0.286–0.791). Moreover, the G allele of rs1135216 appears to be associated with a decreased risk of CC (OR = 0.746; 95%CI: 0.632–0.881). The allele and genotype distribution of rs241441 showed a significant difference between the control and CC groups (P < 0.0038), and the rs241441 G allele was associated with an increased risk of CC (OR = 1.232, 95%CI: 1.092–1.398). In addition, the results of the association between TAP alleles and CC showed that TAP1*020101 and TAP1*0301 have an association with CC (P = 0.001 and P = 0.002, respectively). Our results demonstrate that the TAP1 and TAP2 genes are associated with CC in the Chinese Han population.