bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drivers learn city-scale dynamic equilibrium
Authors: Zhang Ruda , Ghanem Roger 
Published: July 2021

Abstract
Understanding driver behavior in on-demand mobility services is crucial for designing efficient and sustainable transport models. Drivers' delivery strategy is well understood, but their search strategy and learning process still lack an empirically validated model. Here we provide a game-theoretic model of driver search strategy and learning dynamics, interpret the collective outcome in a thermodynamic framework, and verify its various implications empirically. We capture driver search strategies in a multi-market oligopoly model, which has a unique Nash equilibrium and is globally asymptotically stable. The equilibrium can therefore be obtained via heuristic learning rules where drivers pursue the incentive gradient or simply imitate others. To help understand city-scale phenomena, we offer a macroscopic view with the laws of thermodynamics. With 870 million trips of over 50k drivers in New York City, we show that the equilibrium well explains the spatiotemporal patterns of driver search behavior, and estimate an empirical constitutive relation. We find that new drivers learn the equilibrium within a year, and those who stay longer learn better. The collective response to new competition is also as predicted. Among empirical studies of driver strategy in on-demand services, our work examines the longest period, the most trips, and is the largest for taxi industry.
Spectrum and Clinical Characteristics of Gene Mutations in Chinese Pediatric Acute Lymphoblastic Leukemia
Authors: Shen Diying , Liu Lixia , Xu Xiaojun , Song Hua , Zhang Jingying , Xu Weiqun , Zhao Fenying , Liang Juan , Liao Chan , Wang Yan , Xia Tian , Wang Chengcheng , Lou Feng , Cao Shanbo , Qin Jiayue , Tang Yongmin 
Published: July 2021

Abstract
Purpose

The 5-year survival rate of children with acute lymphoblastic leukemia (ALL) is 85–90%, with a 10–15% rate of treatment failure. Next-generation sequencing (NGS) identified recurrent mutated genes in ALL that might alter the diagnosis, classification, prognostic stratification, treatment, and response to ALL. Few studies on gene mutations in Chinese pediatric ALL have been identified. Thus, an in-depth understanding of the biological characteristics of these patients is essential.. The present study aimed to characterize the spectrum and clinical features of recurrent driver gene mutations in a single-center cohort of Chinese pediatric ALL.
Methods

We enrolled 219 patients with pediatric ALL in our single center. Targeted sequencing based on NGS was used to detect gene mutations in patients. The correlation was analyzed between gene mutation and clinical features, including patient characteristics, cytogenetics, genetic subtypes, risk stratification and treatment outcomes using χ2-square test or Fisher’s exact test for categorical variables.
Results

A total of 381 gene mutations were identified in 66 different genes in 152/219 patients. PIK3R1 mutation was more common in infants (p = 0.021). KRAS and FLT3 mutations were both more enriched in patients with hyperdiploidy (P < 0.0001, P = 0.0003, respectively). NRAS, PTPN11, FLT3, and KMT2D mutations were more common in patients who did not carry the fusion genes (all p < 0.05). PTEN mutation was significantly associated with high-risk ALL patients (P = 0.011), while NOTCH1 mutation was common in middle-risk ALL patients (P = 0.039). Patients with ETV6 or PHF6 mutations were more sensitive to steroid treatment (P = 0.033, P = 0.048, respectively).
Conclusion

This study depicted the specific genomic landscape of Chinese pediatric ALL and revealed the relevance between mutational spectrum and clinical features of Chinese pediatric ALL, which highlights the need for molecular classification, risk stratification, and prognosis evaluation.
Minimisation of Overestimation of River Flows in 1D- Hydrodynamic Modeling
Authors: Vashist Komal , Singh K. K. 
Published: July 2021

Abstract
One-dimensional hydrodynamic models overestimate river cross-section derived from freely available SRTM DEMs. The present study aims to minimize the overestimation of river flow. DEM-extracted cross-sections obtained from 30 m and 90 m resolutions show higher elevation values than the actual river cross sections of Krishna and Bhima rivers, India. To minimize the overestimation of the river flow, DEM-extracted cross-sections are modified using known cross-section of the river. The corrections for cross sections extracted from DEM, are obtained by subtracting the DEM-derived cross-sections from a known cross-section of the river. Monsoons flows that occurred in years 2006 and 2009 in Krishna and Bhimariver have been used for modeling. The MIKE HYDRO River model performance with modified DEM-extracted cross-sections of river improves as the correlation coefficient, root mean square error, index of agreement, Nash Sutcliffe efficiency & Percentage deviation in peak (%) values are improved.
Preparation of Activated Carbon From Sunflower Straw by H3PO4 Activation and Its Application for Acid Fuchsin Adsorption
Authors: Zhao Wende , Chen Liping 
Published: July 2021

Abstract
In this work, sunflower straw (SS) was used as the raw material, H3PO4 was used as the activator, and the sunflower straw activated carbon (SSAC) was prepared by the one-step activation method under the impregnation ratio of 1:1, 1:2, 1:3, 1:5 (SS/H3PO4, g/g). The adsorption of acid fuchsin (AF) simulated dye wastewater by SSAC prepared under different immersion ratios has been studied. As the impregnation ratio increases, the pore structures of SSAC changed greatly. SSAC3 had the largest specific surface area (1794.01 m2/g), and SSAC4 had the smallest microporosity (0.0527 cm3/g) and the largest pore volume (2.549 cm3/g). The adsorption kinetics of four types of SSAC to AF were more in line with the quasi-second-order adsorption kinetic model. The Langmuir isotherm model was suitable for describing SSAC3 and SSAC4, and the Freundlich isotherm model was suitable for describing SSAC1 and SSAC2. Thermodynamics showed that the adsorption process was spontaneous and endothermic. At 303 K, SSAC4 showed a removal rate of 97.73% for 200 mg/L AF, and the maximum adsorption capacity of 2763.36 mg/g, which was the highest among the four types of SSAC. This study shows that the sunflower straw activated carbon prepared by the H3PO4 one-step activation method is a green and efficient carbon material and has great application potential in the treatment of dye-containing wastewater.
Toxicopathological and Molecular Studies on Imidacloprid and Hexaflumuron-induced Hepatorenal Toxicity in Rats.
Authors: Hassanen Eman I. , Hussien Ahmed M. , Mehanna Sally , Ibrahim Marwa A. , Hassan Neven H. 
Published: July 2021

Abstract
Pesticides are considered the main source of environmental pollution and causing severe hazardous effects on humans and livestock. Imidacloprid (IC) and hexaflumuron (HFM) are broadly used insecticides for crop protection in the world. Some studies discussed IC toxicity in rats, but the toxicity of HFM doesn’t elucidate yet. So that, the current study aimed to investigate the pathogenesis and the mechanistic way of both IC and HFM induced hepatorenal toxicity in rats with comprehensive insight into its molecular mechanism. 21 male Wistar albino rats were divided into 3 groups as the following: group (1), normal saline; group (2), receiving IC; and group (3), receiving HFM. All the following materials were orally administered every day for 28 days. At the end, all rats were euthanized to collect blood and organ samples (liver and kidneys). The results revealed behavioral alterations in walking, body tension, alertness, and head movement as well as a decrease in body weight of rats receiving either IC or HFM. In addition to increasing the levels of MDA with decreasing GHS levels in liver and kidney homogenates. Both liver and kidney tissues showed extensive histopathological alterations associated with increasing the serum levels of ALT, AST, urea, and creatinine as well as reduction in total proteins, albumin, and globulin levels. Furthermore, there was upregulation of m-RNA levels of caspase-3, JNK, and HO-1 genes with strong positive reaction of caspase-3, TNF-ὰ and NF-KB proteins in both liver and kidneys of rats receiving either IC or HFM compared with the control group. We can conclude that both IC and HFM induced oxidative hepatorenal damage via ROS overproduction that activate NF-KB signaling pathways and mitochondrial and JNK dependent apoptosis pathway.
The Two-years Immune Effect Between 0-1-2-months and 0-1-6-months of HBV Vaccination Schedule in Adults
Authors: Wang Juan , Liu Chang-Hai , Ma Yuanji , Zhu Xia , Luo Liru , Ji Yulin , Tang Hong 
Published: July 2021

Abstract
Background: The short-term 0-1-2-months hepatitis B virus (HBV) vaccination schedule was previously proposed in the adult population; however, its long-term immune effect remains unclear. The present study was aimed to investigate 1) the 2-months and 2-year immune effect of HBV vaccination; and 2) compliance rate between 0-1-2-months and 0-1-6-months vaccination schedules in adults.Method: A total of 1281 subjects tested for HBsAg(-) and Hepatitis B surface antibody (anti-HBs)(-) were recruited. Participants from two distant counties were inoculated hepatitis B yeast vaccine for 10ug per dose each time, with 0-1-2-months (n=606) and 0-1-6-months (n=675) vaccination schedule, sequentially followed-up at two months and two years after the 3rd injection.Results: There was no statistical difference in anti-HBs seroconversion rate between 0-1-2-months and 0-1-6-months vaccination schedule at two months (91.96% vs 89.42%, p=0.229) and two years (81.06% vs. 77.14%, p=0.217). Quantitative anti-HBs level of 0-1-2-months vaccination schedule was not different with 0-1-6-months vaccination schedule at 2 months (anti-HBs1) (342.12 ± 378.42 m IU/ml vs. 392.38 ± 391.96 m IU/ml, p=0.062), but was higher at two years (anti-HBs2) (198.37 ± 286.44 m IU /ml vs. 155.65 ± 271.73 m IU /ml, p=0.048). By subgroup analysis, 0-1-2-months vaccination schedule showed better maintenance (p=0.041) and delayed reinforcement (p=0.019) in comparison to 0-1-6 vaccination schedule. The 0-1-2-months vaccination schedule also increased the 3rd-time injection completion rate (89.49% vs. 84.49%, p=0.010).Conclusion: the 0-1-2-months vaccination could obtain a similar short-term immune effect, but achieve a better long-term immune memory and a higher completion rate in the adult population.Trial registration: None
Removal of Phosphorus from Domestic Sewage by a Constructed Wetland Coupled Microbial Fuel Cell System
Authors: Yu Shuang , Dou Peng , Yin Yue , Wang Peijing , Wang Hao , Han Jinlong , Xu Duo 
Published: July 2021

Abstract
A constructed wetland (CW) coupled microbial fuel cell (MFC) system that treats wastewater and generates electricity was constructed. The total phosphorus in the simulated domestic sewage was used as the treatment target, and the optimal phosphorus removal effect and electricity generation were determined by comparing the changes in substrates, hydraulic retention times, and microorganisms. The mechanism underlying phosphorus removal was also analyzed. The experimental results showed that the best removal efficiencies of the two CW-MFC systems that used magnesia and garnet as substrates were 80.3% and 92.4%, respectively. Phosphorus removal by the garnet matrix mainly depends on a complex adsorption process whereas the magnesia system relies on ion exchange reactions. The CW-MFC system can also generate electricity. The highest output voltage and stable voltage of the garnet system were both higher than those of the magnesia system. The maximum stable voltage of the garnet device was 500 mV, while that of the magnesia device was 290 mV. The microorganisms in the soil and in the electrode within the wetland sediments also substantially changed, indicating that microorganisms positively respond to the removal of organic matter and power generation. Combining the advantages of constructed wetlands and microbial fuel cells also improves phosphorus removal in the coupled system. Therefore, when studying a CW-MFC system, the selection of electrode materials, matrix, and system structure should be taken into account in order to find a method that will improve the power generation capacity of the system and remove phosphorus.
Acute Occlusion of Abdominal Aorta: Duration of Bilateral Limb Ischemia and its Influence on Early-Term and Mid-Term Outcomes
Authors: Skrypnik Denis , Butaev Sultan , Arakelyan Artur , Falco Coral , Vinogradov Roman , Baryshev Alexander , Porhanov Vladimir 
Published: July 2021

Abstract
Background To investigate the influence of duration of bilateral acute limb ischemia (BALI) due to acute aortic occlusion (AAO) on the amputation-free survival in the early- and mid-term follow-ups (FUs). Methods A retrospective analysis of patients treated due to primary occlusion of the infrarenal aorta and BALI was performed. Univariate analysis was used to determine the risk factors of adverse outcomes and to compare the duration of BALI between amputation-free survival and the non-amputation-free survival group. The log-rank test was used to compare amputation-free survival in the FU. Results The data of 16 patients, with a mean age of 70 ± 11 years, were analyzed. Predominantly females (56.3%, 9/16) were included in the study. The median FU was 32 months (range, 26–108 months). The mean ischemia time was significantly shorter in the amputation-free survival group compared to that in the non-amputation-free survival group (7.4 ± 3.5 hours vs. 22.4 ± 16.3 hours, p = .01). The time frame for successful bilateral lower limb revascularization was at <11h (p= .001, Cramer’s V= .71). Amputation-free survival in the early- and mid-term FUs was improved, if the duration of BALI was < 11 hours (log rank test, p = .006). Conclusions The duration of BALI due to AAO < 11 hours was shown to be associated with improved amputation-free survival in the early- and mid-term FUs. Trial registration: The study was retrospectively registered in TCTR international registry (identification no. TCTR20210609002).
Gender Differences are Noted in Factors Associated with Insomnia in Older Adult Outpatients: A Cross-Sectional Study
Authors: Peng Yu-Ting , Hsu Ying-Hsin , Chou Ming-Yueh , Chu Che-sheng , Su Chen-San , Liang Chih-Kuang , Wang Yu-Chun , Yang Tsan , Chen Liang-Kung , Lin Yu-Te 
Published: July 2021

Abstract
Background: Insomnia is a common sleep disturbance in older adults and is associated with many poor health outcomes. This study aimed to investigate the relevance of insomnia in older adult outpatients and to analyze differences between genders in factors associated with insomnia.Methods: This cross-sectional study was conducted in the outpatient clinics of a tertiary hospital in Southern Taiwan from July to September 2018. A total of 400 consecutive subjects aged 60 years or older were recruited. Insomnia was defined as a score of > 6 points on the Athens Insomnia Scale (AIS). Socio-demographics, health behaviors and clinical data were collected by face-to-face interview. Multivariable logistic regression was adopted for statistical analysis of the entire sample and stratified by gender.Results: Participants’ mean age was 74.74 ± 8.54 years, and the majority (93%) had more than one chronic disease. The prevalence of insomnia accounted for 30% (120/400) of all subjects, with males 22.9% (46/201) and females 37.2% (74/199). Gender, appetite, exercise, depressive symptoms, and sleep-related conditions such as short sleep duration, sleeping pills usage, medium-high risk of obstructive sleep apnea(OSA) and restless leg syndrome(RLS) were factors associated with insomnia in older adults. Exercise, sleeping pills usage, and RLS had an independent association with insomnia only in men, while appetite was associated with insomnia in women only.Conclusions: Insomnia is highly prevalent among older adults, predominantly females. Significant differences are found between genders in factors associated with insomnia. Understanding gender differences may help clinicians to modify associated factors when managing older adults with insomnia.
Burden of Liver Cancer Attributable to Five Risk Factors by Specific Etiologies in 204 Countries and Territories
Authors: Li Yizhen , Wei Bajin , Deng Yujiao , Liu Yuanxing , Deng Xinyue , Xiang Dong , Hu Jingjing , Zheng Yi , Xu Peng , Yao Jia , Zhai Zhen , Zhou Linghui , Yang Si , Wu Ying , Zheng Shusen , Dai Zhijun 
Published: July 2021

Abstract
Background Liver cancer has caused a serious disease burden worldwide wherein prognostic risk factors may have had a significant role. However, previous studies have focused on liver cancer distributions and trend variations without analyzing the role of risk factors. Methods We assessed liver cancer burden attributable to five recognized risk factors as well as temporal trends from 1990 to 2019 based on the 2019 Global Burden of Disease Study. The risk exposure levels and their contributed burden were estimated by cause, sex, age, and location. Furthermore, the relationship between the risks and social-demographic index (SDI) was investigated. Results The total liver cancer burden attributable to risk factors is still increasing year by year in terms of death and disability-adjusted life years. However, the burden attributable to alcohol use and smoking has shown a downward trend in recent years. Risk-related burden in males was more than three times as that in females, the burden among the middle-aged and elderly was the most serious, and Central Asia, high-income Asia Pacific and East Asia exhibited the highest burden worldwide. The exposure levels of the five recognized risk factors were generally positively correlated with SDI value. However, the risk-related liver cancer burden first increased and then decreased with the SDI value. Conclusion These findings could help in understanding the role of prognostic risk factors in liver cancer burden, in promoting the development of relevant studies, and in proposing better prevention and control policies tailored to local conditions.
Molecular Diversity, Haplotype Distribution and Gene Flow of Bipolaris Sorokiniana Fungus Causing Spot Blotch Disease in Different Wheat Growing Zones
Authors: Kashyap Prem Lal , Kumar sudheer , Sharma Anju , Kumar Ravi Shekhar , Mahapatra Sunita , Jasrotia Poonam , Singh Gyanendra Pratap 
Published: July 2021

Abstract
Bipolaris sorokiniana (BS) is an economically important fungal pathogen causing spot blotch of wheat (Trtiticum aestivum) and found in all wheat growing zones of India. Very scanty and fragmentary information is available on its genetic diversity. The current research is the first detailed report on the geographic distribution and evolution of BS population in five geographically distinct wheat growing zones [North Western Plain Zone (NWPZ), North Eastern Plain zone (NEPZ); North Hill Zone (NHZ), Southern Hill Zone (SHZ) and Peninsular Zone (PZ)] of India, studied by performing nucleotide sequence comparison of internal transcribed spacer region of 183 isolates. A moderate to high levels of haplotypic diversity was noticed in different wheat growing zones. Phylogenetic analysis suggests that B. sorokiniana exist in two distinct lineages as all isolates under study were grouped in two different clades and found analogous to the findings of haplotypic and median joining network analysis. The genetic parameters revealed the existence of 59 haplotypes with three major haplotypes (H_2, H_3, and H_25) which showed star-like structure network surrounded by several single haplotypes, revealing high frequency of the mutations ((Eta = 2 – 437) in total analyzed population. H_3 was observed as a predominant haplotype and prevalent in all the five zones. Moderate level of genetic differentiation was found between NEPZ and PZ (Fst = 0.563), whereas it was low between NEPZ and NHZ (Fst = -0.062). High level of gene flow was noticed between NWPZ and NEPZ (Nm = 14.32), while it was found minimum between SZ and NHZ (Nm = 0.50). Moreover, negative score of neutrality statistics (Tajima’s D and Fu’s FS test) for NWPZ, PZ and SHZ populations, suggested recent population expansion in these zones. However, positive score for both the neutrality tests observed in NEPZ and NHZ indicated the dominance of balancing selection in structuring their population. Recombination events were observed in the NWPZ, NEPZ and NHZ population, while it was absent in SHZ and PZ population. Thus, the lack of any specific genetic population structure in all the zones indicates for the expansion history only from one common source population i.e. NWPZ, a mega zone of wheat production in India. Overall, it seems that the predominance of individual haplotypes with a moderate level of genetic variation and men mediated movement of contaminated seed and dispersal of inoculum, mutations and recombination as prime evolutionary processes play essential role in defining the genetic structure of BS population.
Modeling And Optimization Study of PEMFC Fueled With Ammonia Reforming Gas
Authors: Zhao Jian Feng , Qianchao LIANG , Yifan LIANG 
Published: July 2021

Abstract
The storage of high-purity hydrogen has been a technical challenge limiting the large-scale application of fuel cells. Ammonia is an ideal hydrogen storage carrier with a storage mass density of up to 17 wt% and can be easily liquefied for storage and transportation, but ammonia requires complex separation equipment to re-generate high-purity hydrogen, which greatly reduces its advantages in hydrogen storage. Therefore, the development of direct ammonia reforming gas fuel cells, which can avoid complicated pure hydrogen separation equipment, has a very meaningful impact and can greatly expand the application of fuel cells. In this paper, we study the modeling simulation of ammonia reforming gas-fueled proton exchange membrane fuel cell (PEMFC) based on the preliminary experiments, and the concentration-dependent Butler-Volmer electrochemical model is used to simulate the ammonia reforming gas-fueled PEMFC. Firstly, the concentration-dependent Butler-Volmer electrochemical model was improved by adding a correction factor for the concentration difference polarization based on the characteristics of the experimental data to obtain a correction factor of 1.65 based on the experimental data; secondly, the effect of the anode channel length on the fuel cell performance was investigated. The results show that: firstly, the improved concentration-dependent Butler-Volmer electrochemical model can better match the experimental results; secondly, the anode channel length has less effect on the maximum power density and hydrogen concentration in the exhaust gas, and the current density gradient increases with decreasing anode channel length, but the fuel flow resistance decreases. The results of the study can provide a reference for the simulation study of PEMFC using ammonia reforming gas as fuel.