bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bayesian Survival Analysis of Heart Failure Patients: A Case Study in Jimma University Medical Center, Jimma, Ethiopia
Authors: Tefera Tafese Ashine , Muleta Geremew , Tadesse Kenenisa 
Published: April 2021

Abstract
Heart failure is failure of the heart to pump blood with normal efficiency and globally growing public health issue with high death rate over the world including Ethiopia. The aim of this study was to identify factors affecting the survival time of heart failure patients in Jimma University Medical Center. To reach the aim, 409 heart failure patients were including in the study based on data taken from medical record of patients enrolled during January, 2016 to January, 2019. Kaplan Meier plots and log rank test were used for comparison of survival function; Bayesian survival models was used to identify factors affecting the survival time heart failure patients. Of the total patients in the study 164 (40.1%) were died. The estimated median survival time of patients was 31 months. Bayesian log-normal accelerated failure time model fit heart failure data-set better than other Bayesian accelerated failure time models used in this study. From the results of this model shows that the survival time of heart failure patients significantly affected by age, chronic kidney disease, diabetes mellitus, etiology of heart failure, hypertension, anemia, smoking cigarette and stages of heart failure. Bayesian log-normal accelerated failure time model describes the heart failure data-set well. Age group (49 to 65 years and greater than 65 years); etiology of heart failure (rheumatic valvular heart disease, hypertensive heart disease and Other diseases); presence of hypertension; presence of anemic; presence of chronic kidney disease; smokers; diabetes mellitus (type I and type II diabetic); and stages of heart failure (II, III and IV) were prolong the timing death of heart failure patients. The hospital, Jimma University medical center, need to improve public awareness for early detection of heart failure.
Mathematical Modelling and Simulation of Band Pass Filters Using The Floating Admittance Matrix Method.
Authors: ROY SANJAY KUMAR , Bhargava Cherry , Sharma Kamal Kumar , Singh Brahmadeo Prasad 
Published: April 2021

Abstract
This article describes the Band Pass Filters mathematical modeling, focusing on solutions using the Floating Admittance matrix method (FAM). The solution using the FAM Method looks superior for any circuit analysis. We are introducing a new strategy resulting in one of the best designs of the Bandpass and the Notch Filters. This document provides compelling reasons for the proposed Process, demonstrates its benefits and many valuable extensions and resources.
Physiological Response of Garlic (Allium Sativum) to Elevated Tropospheric Ozone in High Altitude Region of Western Ghats, Tamil Nadu, India
Authors: JawaharJothi Gayathri , Kovilpillai Boomiraj , Subramanian Avudainayagam , Mani Jayabalakrishnan Raja , Kumar Sudhir 
Published: April 2021

Abstract
A pot culture study was conducted at Horticultural Research Station, Ooty to assess the effect of ground level ozone on physiology in garlic plant and to find out the suitable remedial measures against ground level ozone. The potted soil was found to be acidic in nature with very low salt concentration, very high in organic carbon, medium in nitrogen, phosphorus and high in potassium. Elevated ozone levels (150ppb and 200ppb) had significantly reduced the garlic plant chlorophyll content, stomatal conductance, photosynthetic rate, pungency and total soluble solids. The highest chlorophyll content (33.97µmolm-2) was observed under ambient ozone level (T1) and the lowest chlorophyll content (12.68µmolm-2) was observed in elevated ozone exposure at 200 ppb (T3), the highest stomatal conductance (0.45mmol m-2s-1) was recorded in Ambient Ozone level + foliar spray 3% Panchagavya (T4), and the lowest stomatal conductance (0.11mmol m-2s-1) was observed in elevated ozone exposure at 200 ppb (T3). Since, the elevated ozone had significant reduction in photosynthetic rate in garlic, the lowest was observed (0.82µmol CO2 s-1m-2) in T3- Elevated ozone exposure at 200 ppb and the highest photosynthetic rate (3.02µmol CO2 s-1m-2) was observed in treatment T4- Ambient Ozone level + foliar spray 3% Panchagavya after a week. When coming to quality of garlic bulbs, the highest pungency content was found in Ambient Ozone level + foliar spray 0.1% Ascorbic acid and the lowest was observed in Elevated ozone exposure at 200 ppb (T3) furthermore, in observing the garlic quality where total soluble solids (TSS) showed that the treatment Ambient Ozone level + foliar spray 3% Panchagavya (40.00°Brix) as highest and the treatment Elevated ozone exposure at 200 ppb (T3) recorded the lowest. Thus the tropospheric ozone has detrimental impact on physiological responses, which will reduce crop growth and yield. The ozone protectants helped in scavenging the O3 from apoplast of the crops and among the ozone protectants, neem oil acted as a good ozone scavenger followed by ascorbic acid and panchagavya to improve the physiological response of garlic plant under elevated tropospheric ozone levels.
Pseudodesulfovibrio Alkaliphilus, Sp. Nov., An Alkaliphilic Sulfate-Reducing Bacterium Isolated From a Terrestrial Mud Volcano
Authors: Frolova Anastasia , Merkel Alexander Y. , Kuchierskaya Alexandra A. , Bonch-Osmolovskaya Elizaveta A. , Slobodkin Alexander I. 
Published: April 2021

Abstract
The diversity of anaerobic microorganisms in terrestrial mud volcanoes is largely unexplored. Here we report the isolation of a novel sulfate-reducing alkaliphilic bacterium (strain F-1T) from a terrestrial mud volcano located at the Taman peninsula, Russia. Cells of strain F-1T were Gram- -negative motile vibrios with a single polar flagellum; 2.0–4.0 µm in length and 0.5 µm in diameter. The temperature range for growth was 6–37°C, with an optimum at 24°C. The pH range for growth was 7.0–10.5, with an optimum at pH 9.5. Strain F-1T utilized lactate, pyruvate, and molecular hydrogen as electron donors and sulfate, sulfite, thiosulfate, elemental sulfur, fumarate or arsenate as electron acceptors. In the presence of sulfate the end products of lactate oxidation were acetate, H2S and CO2. Lactate and pyruvate could also be fermented. The major product of lactate fermentation was acetate. The main cellular fatty acids were anteiso-С15:0, С16:0, С18:0, and iso-С17:1ω8. Phylogenetic analysis revealed that strain F-1T was most closely related to Pseudodesulfovibrio aespoeensis (98.05% similarity). The total size of the genome of the novel isolate was 3.23Mb and the genomic DNA G + C content was 61.93 mol%. The genome contained all genes essential for dissimilatoty sulfate reduction. We propose to assign strain F-1T to the genus Pseudodesulfovibrio, as a new species, Pseudodesulfovibrio alkaliphilus sp. nov. The type strain is F-1T (= KCTC 15918T = VKM B-3405T).
Regional Cerebral Blood Perfusion Changes in Chronic Stroke Survivors as Potential Brain Correlates of The Functional Outcome Following Gamified Home-Based Rehabilitation (IntelliRehab)
Authors: Firwana Younis , Zolkefley Mohd Khairul Izamil , Hatta Hasnetty Zuria Mohamed , Rowbin Christina , Nassir Che Mohd Nasril Che Mohd , Hanafi Muhammad Hafiz , Abdullah Mohd Shafie , Keserci Bilgin , Lannin Natasha A. , Mustapha Muzaimi 
Published: April 2021

Abstract
Background: Hospital-based stroke rehabilitation for stroke survivors in developing countries may be limited by staffing ratios and length of stay that could hamper recovery potential. Thus, a home-based, gamified rehabilitation system (i.e. IntelliRehab) was tested for its ability to increase cerebral blood flow (CBF), and the secondary impact of changes on the upper limb motor function and functional outcomes. Objective: To explore the effect of IntelliRehab on CBF in chronic stroke patients and its correlation with the upper limb motor function. Methods: Two-dimensional pulsed Arterial Spin Labelling (2D-pASL) was used to obtain CBF images of stable, chronic stroke subjects (n=8) over 3-months intervention period. CBF alterations were mapped and the detected differences were marked as regions of interest. Motor functions represented by Fugl-Meyer Upper Extremity Assessment (FMA) and Stroke Impact Scale (SIS) were used to assess the primary and secondary outcomes, respectively. Results: Regional CBF were significantly increased in right inferior temporal gyrus and left superior temporal white matter after 1-month (p=0.044) and 3-months (p=0.01) of rehabilitation, respectively. However, regional CBF in left middle fronto-orbital gyrus significantly declined after 1-month of rehabilitation (p=0.012). Moreover, SIS-Q7 and FMA scores significantly increased after 1-month and 3-months of rehabilitation. There were no significant correlations, however, between CBF changes and upper limb motor function. Conclusions: Participants demonstrated improved motor functions, supporting the benefit of using IntelliRehab as a tool for home-based rehabilitation. However, the chronic nature of the stroke in recruited subjects may have limited potential for within-participant improvements.
Comparison of Clinical Characteristics of Adolescent Women With Different Subtypes of Anorexia Nervosa With First Episode and Without Treatment
Authors: zhang renyun , yang limin , xu defeng , ma haibo 
Published: April 2021

Abstract
Background

This study compared whether differences between different anorexia nervosa(AN)subtypes(R-AN,B-AN) in multiple organ complications.
Methods

Peripheral white blood cells (WBCs),thyroid function,etc, were measured in 53 patients (R-AN = 30,B-AN = 23)and compared 55 healthy controls (HCs)
Results

Compared with HCs, significant differences between R-AN in T, P, DBP, SBP WBC, PRL, TT4, TSH, FT3, FT4, TT3, TP, HGB, RBC,, EDI total score and DT, I, ID, IA ,BD, P and MF. Compared with HCs, significant differences between B-AN in DBP, WBC, PRL, TT4, FT3, FT4, TT3, TP, HGB, RBC,, EDI total score, DT, BD, I, ID, and IA and differences in PLT and P. significant differences between R-AN and B-AN in T, P, DBP, SBP, PRL, TSH, B, FT4, and HGB. In R-AN, BMI negatively correlated with amenorrhea, and PRL EDI total score, DT, BD, and P positively correlated with DBP, SBP, HGB and GLB. In B-AN, BMI negatively correlated with amenorrhea, PRL, EDI total score, and DT, and B, BD, positively correlated with T and DBP.
Conclusion

The effects of R-AN and B-AN on T, P, DBP, SBP, PRL TSH, B, FT4, and HGB were different, and BMI played a role in the changes.
Anatomical Dimensions of the Lumbar Dural Sac Predict the Sensory Block Level of Continuous Epidural Analgesia during Labor
Authors: Xu Chen-yang , Liu Can , Jin Xiao-ju , Yang Fan , Xu Fang , Qian Wan-Di , Guo Wen-jun 
Published: April 2021

Abstract
Background: The anatomical dimensions of the lumbar dural sac determine the sensory block level of spinal anesthesia; however, whether they show the same predictive value during continuous epidural anesthesia (CEA) remains undetermined. We designed the present study to verify the efficacy of the anatomical dimensions of the lumbar dural sac in predicting the sensory block level during labor analgesia. Methods: A total of 122 parturients with singleton pregnancies requesting labor analgesia were included in this study. The lumbar dural sac diameter (DSD), lumbar dural sac length (DSL), lumbar dural sac surface area (DSA) , and lumbar dural sac volume (DSV) were measured with an ultrasound color Doppler diagnostic apparatus. CEA was performed at the L2-L3 interspace. After epidural cannulation, an electronic infusion pump containing 0.08% ropivacaine and sufentanil 0.4 µg/ml was connected. The sensory block level was determined with alcohol-soaked cotton, a cotton swab, and a pinprick. The analgesic efficacy of CEA was determined with a visual analog scale (VAS). Divided the parturients into two groups: "ideal analgesia" and "non-ideal analgesia", and compared the groups by t test. Pearson's correlation was performed to evaluate the association between the anatomical dimensions of the lumbar dural sac and sensory block level. Multiple linear regression analysis was used to create a model for predicting the sensory block level. Results: In the "ideal analgesia" group, the height, DSL, DSA, DSV and DSD were significantly smaller, and the BMI was significantly larger (P<0.05) (Table 1). In addition, the DSL demonstrated the strongest correlation with the peak level of pain block (r=-0.816, P<0.0001; Figure 2A), temperature block (r=-0.874, P<0.0001; Figure 3A) and tactile block (r=-0.727, P<0.0001; Figure 4A). Finally, multiple linear regression analysis revealed that the DSL and BMI contributed to predicting the peak sensory block level. Conclusion: In conclusion, our study shows that the sensory block level of CEA is higher when the DSL, DSA, DSV and DSD of puerpera are lower. The DSL and BMI can be treated as predictors of the peak sensory block level in CEA during labor analgesia.
Direct Evidence Of Sex In Symbiodiniaceae And A Hypothesis About Meiosis
Authors: Figueroa R.I. , Howe-Kerr L. , Correa A.M.S. 
Published: April 2021

Abstract
Dinoflagellates in the family Symbiodiniaceae are obligate endosymbionts of diverse marine invertebrates, including corals, and impact the capacity of their hosts to respond to climate change-driven ocean warming. Understanding the conditions under which increased genetic variation in Symbiodiniaceae arises via sexual recombination can support efforts to evolve thermal tolerance in these symbionts and ultimately mitigate coral bleaching, the breakdown of the coral-Symbiodiniaceae partnership under stress. However, direct observations of meiosis in Symbiodiniaceae have not been reported, despite various lines of indirect evidence that it occurs. We present the first cytological evidence of sex in Symbiodiniaceae based on nuclear DNA content and morphology using Image Flow Cytometry, Cell Sorting and Confocal Microscopy. We show Symbiodiniaceae cells undergo gamete conjugation, zygote formation and meiosis within a dominant reef-building coral in situ. On average, sex was detected in 1.5% of the cells analyzed (N=10.000-40.000 cells observed per sample in a total of 20 samples obtained from 3 coral colonies). We show that meiosis follows a two-step process described in other dinoflagellates, in which diploid zygotes form dyads during meiosis I and triads and tetrads as final products of meiosis II. This study sets the stage for investigating environmental triggers of Symbiodiniaceae sexuality and can accelerate the assisted evolution of a key coral symbiont in order to combat reef degradation.
Evaluation of Beliefs and Attitudes of Child Labor Caregivers About Mental Disorders First Aid and Stigma
Authors: Ghadirian Laleh , Sayarifard Azadeh 
Published: April 2021

Abstract
Background: The beliefs and attitudes of caregivers of working children about mental health issues and first aid, as well as their attitudes about the stigma of mental health problems can affect their motivation seek professional help for affected children. The aim of this study was to assess the mental health literacy of child labor caregivers about first aid for mental health and their attitudes about stigma of mental disorders.Methods: In this cross-sectional study, the questionnaire was the Depression Health Literacy Questionnaire. All caregivers of working children covered by a NGO in the 17th district of Tehran who wanted to participate were included in the study. Results: Questionnaires of 129 caregivers were analyzed. Their mean age was 32.6 (±7) years. Of which 128 (99.2%) were women. Only 37 people (30.3%) were confident in their ability to help their children in case of depressive symptoms. The majority 109 (84.5%) of participants believed that asking a depressed child about suicidal ideation was harmful.Conclusion: According to the findings of this study, the literacy of child labor caregivers about mental health first aid is not enough and there is need to conduct interventions including providing the necessary trainings in this area.
Long Noncoding RNA NEAT1 Promotes Tumorigenesis in H. Pylori Gastric Cancer By Sponging miR-30a To Regulate COX-2/BCL9 Pathway
Authors: Rao Xiwu , Liu Ningning , Jia Ru , Feng Yuanyuan , Zhang Zhaozhou , Zhou Lihong , Han Gang , Wang Ziyuan , Cen Rong , Shi Nuolin , Zhu Huirong , Huang Chen , Liu Xuan , Ji Qing , Li Qi 
Published: April 2021

Abstract
Background: Helicobacter pylori (H. pylori) is a carcinogenic factor for gastric cancer. Our previous study demonstrated that H. pylori decreased the expression of microRNA(miRNA)-30a to promote the tumorigenesis in gastric cancer. However, the upstream regulatory mechanism of miR-30a hasn’t well-elucidated. In this study, we found the long non‑coding RNA (lncRNA) NEAT1 may sponge miR-30a to regulate COX-2/BCL9 pathway. Methods: The expression of NEAT1 was detected in gastric cancer tissues and tumour adjacent tissues by fluorescence in-situ hybridization(FISH) analysis and RT-qPCR. LncRNA-miRNA interaction networks were constructed using the RNAhybird and Starbase v.2.0. and then validated using dual-luciferase assay. The effects of NEAT1 dysregulation on the proliferative, migratory and invasive abilities of H. pylori filtrate infected gastric cancer cells were observed by cell counting kit-8 (CCK-8), colony formation, wound healing test and transwell assays. Western blot and RT-qPCR were performed to detect protein and RNA expression. The Immunohistochemistry(IHC) was carried out to analyze the location and expression of COX-2 and BCL9Results: FISH and RT-qPCR demonstrated that the expression of NEAT1 was up-regulated in gastric cancer tissues, especially in H. pylori gastric cancer tissues, and the expression of NEAT1 is negatively correlated with miR-30a(miR-30a-3p, miR-30a-5p). The proliferation, migration and invasion of H. pylori filtrate infected gastric cancer cells could be largely enhanced by the up-regulation of NEAT1, while the downregulation of NEAT1 decreased these abilities, and miR-30a could reverse the effect of NEAT1 on these abilities. Dual-luciferase assay identified that NEAT1 directly targeted miR-30a(miR-30a-3p, miR-30a-5p).Due to miR-30a(miR-30a-3p, miR-30a-5p) negatively regulated the expression of downstream COX-2 and BCL9, NEAT1 was identified to indirectly upregulate the expression of COX-2 and BCL9.IHC showed that the expression of COX-2 and BCL9 were increased in H. pylori gastric cancer tissues.Conclusion: The study demonstrated that lncRNA NEAT1 may act as a promoter oftumorigenesis in H. pylori gastric cancer, by sponging miR-30a(miR-30a-3p, miR-30a-5p) to regulate COX-2/BCL9 pathway.
WITHDRAWN: The effects of demographic characteristics and public healthcare systems on COVID-19 mortality risk in the Global South: GIS-based and artificial neural network techniques
Authors: Mansour Shawky , Abulibdeh Ammar , Alahmadi Mohammed , Ramadan Al Nazir 
Published: April 2021

Abstract
The coronavirus disease (COVID-19) that appeared in 2019 gave rise to a major global health crisis that is topping global health, socioeconomic and intervention programme agendas in 2020. Although the outbreak of COVID-19 has substantial and devastating impacts on developed countries, the countries of Global South share a higher proportion of the epidemic’s effects as shown particularly in morbidity and mortality rates in low-income countries . Globally, as at 13th June 2020, the total number of mortality cases was 428,337 of which 9% were in Asia (38,915) and 13.5% in South America (57,896) while 1.4% were in Africa (6080). The number of infections and deaths is still increasing rapidly at the time of writing. Modelling the effects of underlying factors and disease mortality is essential to plan effective control strategies for disease transmission and risks. The relationship between COVID-19 mortality rates and socio-demographic and health determinants can highlight various epidemic fatality risks. In this research, Geographic Information Systems (GIS) and an Artificial Neural Network (ANN) Multilayer Perceptron (MLP) were adopted to model and examine variations in COVID-19 mortality rates in the Global South. The model’s performance was tested using statistical measures of Mean Square Error (MSE), Root Mean Square Error (RMSE), Mean Bias Error (MBE), and the determination coefficient R2. The findings of this study indicated that the most important variable in explaining spatial mortality rate variations was the size of the elderly (65 and above) population . This was followed first by accessibility to handwashing facilities and second by hospital beds per 1000 population. Mapping the explanatory variables and estimated mortality rates and determining the importance of each variable in explaining the spatial variation of COVID-19 death rates across countries of the Global South can shed light on how public healthcare and demographic structures can offer policymakers invaluable guidelines to planning effective intervention strategies.
Exploring Formation Mechanism of Medical Collaborative Practices in Multi-level Market from an Infra-marginal Perspective
Authors: Wang Sufen 
Published: April 2021

Abstract
Purpose: The purpose of this paper to explore a set of methods to formally display and analyze the nature and laws of the emergence and evolution of all kinds of medical collaborative practices (MCPs) within multi-level market.Methodology: Based on Yang’s neoclassical economics, the paper argues that the reason for the origin of MCPs with multi-level market is the division of labor for different medical services and medical transaction service. From an infra-marginal perspective, the study processes are (1) to build a role generation model for collaborators. (2) to determine the role boundaries of collaborators by calculating the corner solution, and formalize the entanglement between role identities and specific MCPs through the corner equilibrium analysis. (3) to evaluate the stability of different forms of MCPs by general equilibrium analysis, and analyze their possible evolutionary paths of various MCPs by sensitivity analysis of the stability conditions of different structures. Results: (1) A role generation model of "producer-consumer", which is composed of three functions and involves three economic parameters, reflects the coexistence of division and cooperation, and integrate the influencing factors with process views. (2) The paper extracts eight role models and six structures of MCPs with corner equilibrium, and further formalizes the different ways of legalization of specific role identities in different MCPs in no market, or single-level or multi-level market. (3) Three structures (structure A with no market, structure CN with single-level market and structure CC with two-level market) have global equilibrium in different parameter spaces. With the increase of learning cost of medical services and medical transaction services, there are two structural evolution paths more likely to occur: " A - >CN -> CC " and "CN -> CC ->A".Conclusions: The research will provide theoretical basis for the government to select, formulate and implement the relevant policies of specific MCP, and help IT companies better develop internet medical service transaction platforms.