bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inorganic Phosphorous, Lime and Vermicompost Induced Changes on Phosphorus Fractions and Other Properties of Acidic Soil of Cheha District, Ethiopia
Authors: Alemu Bereket Ayenew , Melese Asmare 
Published: March 2021

Abstract
Background: In acid soils, soluble inorganic phosphorus is fixed by aluminum and iron, so that phosphorous availability to plant would be inhibited. Thus, an incubation study was conducted to evaluate the effects of lime, vermicompost, and mineral P fertilizer on the distribution of P fractions and oxalate and dithionite extractable aluminum and iron. The treatments consisted of three rates of phosphorous (0, 74.51 and 149.01 kg P ha-1), three rates of vermicompost (0, 5 and 10 ton VC ha-1) and four rates of lime (0, 5.70, 9.20, and 11.50 ton CaCO3 ha-1). The experiment was laid out as a complete randomized design in a factorial arrangement. Results: Combined application of lime, vermicompost and mineral P significantly increased (p<0.05) labile phosphorus fractions and decreased potential sorption capacities of the soil. As the increased soil pH, reduced exchangeable acidity and oxalate extractable Fe and Al the integrated applications of these amendments fixed aluminum and iron instead of phosphorus, thus rendering phosphorus available by keeping the inorganic phosphorus in a bioavailable labile phosphorus pool compared to sole application of the amendments. Conclusions: Combined applications of lime, vermicompost and inorganic P to acidic soils of Goha-1 in Cheha district could convey enhanced amount of available P and ensures the maintenance of higher levels of labile P. It might also contribute towards meeting crop P requirements.
Addressing single spin crossover molecules in a two-dimensional monolayer
Authors: Tong Yongfeng , Kelaï Massine , Bairagi Kaushik , Repain Vincent , Lagoute Jérôme , Girard Yann , Rousset Sylvie , Boillot Marie-Laure , Mallah Talal , Enachescu Cristian , Bellec Amandine 
Published: March 2021

Abstract
Bistable spin-crossover molecules are particularly interesting to the development of innovative electronic and spintronic devices as they present two spin states that can be controlled by external stimuli.
In this purpose, being able to switch at will the spin state of a single molecule in a dense molecular array is a key milestone. However, the elastic interactions between the molecules favour more cooperative behaviour where patches of neighbouring molecules switches simultaneously. We demonstrate here that the interaction of iron II spin-crossover molecules with a metallic substrate can strongly reduce their cooperative behaviour until addressing independently single molecular spin state. Mechanoelastic model is able to reproduce well such findings.
The key factors affecting cumulative live birth rate after single oocyte retrieved in women during IVF/ICSI-ET: a retrospective analysis of 1380 PCOS patients
Authors: Li You , Xia Leizhen , Tan Jun , Wu Qiongfang , Zhang Ziyu 
Published: March 2021

Abstract
Background: The factors affecting the cumulative live birth rate (CLBR) of PCOS patients who received in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) are unknown.Methods: Here we carried out a retrospective analysis of 1380 PCOS patients who received IVF/ICSI-ET for the first time from January 2014 to December 2016. According to the cumulative live births of PCOS patients after single oocyte collection, they were divided into cumulative live births group (group A) and non-cumulative live births group (group B).Results: The conservative cumulative live birth rate was 63.48%. There were 876 cumulative live births (group A) and 504 non-cumulative live births (group B) according to whether the patients had live births or not. Competition analysis showed that duration of infertility, primary/secondary type of infertility, stimulation protocols, starting dose of gonadotrophins and oocyte retrieved numbers were significantly correlated with CLBR. The Cox proportional risk regression model of PCOS patients showed that stimulation protocols had a significant impact on CLBR. Patients in the GnRH-antagonist protocol group and the mild stimulation protocol had lower CLBR than those in the Prolonged GnRH-agonist protocol, which was statistically significant. PCOS patients with the starting dose of gonadotrophins greater than 112.5u had lower CLBR than those with less than 100u, which was statistically significant. Women with 11-15 oocytes and 16-20 oocytes had higher CLBR than women with 1-9 oocytes, which was statistically significant.Conclusions: According to our statistical results, patients with PCOS represent a challenge for reproductive medicine.
EMID1: a multifunctional molecule identified in a murine model for the invasion- independent metastasis pathway
Authors: Kawata Takuya , Muramatsu Koji , Shishito Namiko , Ichikawa-Tomikawa Naoki , Oishi Takuma , Kakuda Yuko , Akiyama Yasuto , Yamaguchi Ken , Sakamoto Michiie , Sugino Takashi 
Published: March 2021

Abstract
Our previous analysis using a mouse metastasis model identified EMI Domain Containing 1 (EMID1) as a potential candidate metastasis-promoting gene. Although EMID1 was isolated as a member of the Emu gene family, which is expressed during mouse embryogenesis, little is known about the molecule. We sought to clarify the molecular function of EMID1 and the protein expression. Overexpression and knockdown studies using mouse cell lines identified two novel functions of EMID1: intracellular signaling involving enhancement of cell growth via cell cycle promotion and suppression of cell motility, and inhibition of cell-matrix adhesion by extracellularly secreted EMID1. EMID1 deposited on the culture dish induced self-detachment of cells that overexpressed the protein and inhibited adhesion of additionally seeded cells. This multifunctional property involving both intracellular signaling and the extracellular matrix suggests that EMID1 may be a matricellular proteins. Expression analysis using immunohistochemical staining revealed expression of EMID1 that was limited to chief cells of the gastric fundic gland and β cells of the pancreatic islets in normal adult human tissues, implying cell-specific functions of this molecule. In addition, increased expression of EMID1 protein detected in some cases of human cancers implies that EMID1 might be a new therapeutic target for cancer treatment.
Labor institution environment and labor agglomeration based on provincial panel data analysis
Authors: Guan Huaping , Tao Aiyuan , Yang Fan 
Published: March 2021

Abstract
With the shift in regional economic patterns in China, Chinese labor forces are showing a trend toward concentration. Many scholars are analyzing this trend of labor agglomeration from the perspective economies of scale and transaction costs. This study explains the phenomenon of labor agglomeration from the perspective of the labor system environment. First, it considers that the labor system environment includes the social contract environment and labor contract environment. Second, it attempts to show that a good labor system environment can promote labor agglomeration through theoretical analysis, while technological advancement can promote the agglomeration of professional and technical talents. Third, this study uses provincial panel data to conduct an empirical analysis. Finally, the paper presents some policy suggestions for maintaining a good labor system environment, including improving the level of public service of the floating population and building harmonious labor relations.
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
Authors: Wang Yue , Yang Siwy Ling , DeFalco Louis , Anderson Danielle , Zhang Yu , Aw Ashley , Lim Su Ying , Lim Xin Ni , Tan Antson Kiat Yee , Zhang Tong , Chawla Tanu , Su Yan , Lezhava Alexander , Merits Andres , Wang Lin-Fa , Roland Huber 
Published: March 2021

Abstract
SARS-CoV-2 has emerged as a major threat to global public health, resulting in global societal and economic disruptions. Here, we investigate the intramolecular and intermolecular RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 virus in cells using high throughput structure probing on Illumina and Nanopore platforms. We identified twelve potentially functional structural elements within the SARS-CoV-2 genome, observed that identical sequences can fold into divergent structures on different subgenomic RNAs, and that WT and Δ382 virus genomes can fold differently. Proximity ligation sequencing experiments identified hundreds of intramolecular and intermolecular pair-wise interactions within the virus genome and between virus and host RNAs. SARS-CoV-2 binds strongly to mitochondrial and small nucleolar RNAs and is extensively 2’-O-methylated. 2’-O-methylation sites in the virus genome are enriched in the untranslated regions and are associated with increased pair-wise interactions. SARS-CoV-2 infection results in a global decrease of 2’-O-methylation sites on host mRNAs, suggesting that binding to snoRNAs could be a pro-viral mechanism to sequester methylation machinery from host RNAs towards the virus genome. Collectively, these studies deepen our understanding of the molecular basis of SARS-CoV-2 pathogenicity, cellular factors important during infection and provide a platform for targeted therapy.
Particulate Matter Concentrations and Their Association With COVID-19 Related Mortality in Mexico During June 2020 Saharan Dust Event&nbsp;
Authors: Kutralam-Muniasamy Gurusamy , Pérez-Guevara Fermín , Martínez Ignacio Elizalde , Chari Shruti Venkata 
Published: March 2021

Abstract
The present study evaluated the impact of Saharan dust event on particulate matter (PM; PM10 and PM2.5) concentrations by analyzing the daily average PM data between Saharan dust days (June 23 - 29, 2020) and non-Saharan dust days (June 15 to June 22 and June 30 to July 12, 2020) for four major affected regions in Mexico and by comparing with three major previous events (2015, 2018 and 2019). The results showed PM10 and PM2.5 concentrations were 2-5 times higher during the Saharan dust event with the highest daily averages of 197 μg/m3 and 94 μg/m3, respectively and exceeded the Mexican standard norm (NOM-020-SSA1-2014). When comparing with the previous Saharan dust episodes of 2015, 2018 and 2019, the levels of PM10 and PM2.5 considerably increased and more than doubled across Mexico. The correlation analysis revealed a positive association of PM levels with the number of daily COVID-19 cases and deaths during Saharan dust event. Furthermore, the human health risk assessment showed that the chronic daily intake and hazard quotient values incremented during Saharan dust days compared to non-Saharan days, indicating potential health effects and importance of taking necessary measures to ensure better air quality following the COVID-19 pandemic.
A Design of Compact Wideband Antenna Based on Hybridization of Minkowski Fractal Curves on Hexagonal Patch and Partial Ground Plane with Truncated Corners
Authors: Bharti Gurpreet , Sivia Jagtar Singh 
Published: March 2021

Abstract
In this manuscript, a compact wideband antenna using a partial ground plane has been designed by the hybridization of Minkowski fractal curves on the hexagonal radiating patch. Further, the corners of this partial ground plane have been truncated and the Minkowski curves superimposed on each truncated corner and finally, the L – shaped stub has been employed to enhance the performance parameters of the antenna in terms of the number of frequency bands and impedance bandwidth. Different prototypes of an antenna have been compared and found that prototype with L – shaped stub and ground plane with truncated corners using Minkowski curve (proposed prototype) exhibits better antenna performance parameters. The proposed prototype of the antenna reveals the maximum bandwidth of 10.86GHz (140.10%) with four distinct frequency bands 4.4, 7.1, 10.8, 16.3GHz. Designed antenna has also been fabricated and tested for authentication of simulated results with measured results and found in reasonable agreement with each other. The proposed antenna uses a low-cost FR4 substrate with a compact overall size of 24×30×1.6mm3. Due to the wider bandwidth, stable radiation pattern, and gain at the desired frequency points, the proposed antenna can be used for different wireless applications.
Dendrimer-modified Gold Nanorods as a Platform for Combinational Gene Therapy and Photothermal Therapy of Tumors
Authors: Ye Lili , Chen Yaoming , Mao Jizong , Lei Xiaotian , Yang Qian , cui chunhui 
Published: March 2021

Abstract
Background: The exploitation of novel nanomaterials combining diagnostic and therapeutic functionalities within one single nanoplatform is challenging for tumor theranostics.Methods: In this work, we synthesized dendrimer-modified gold nanorods for combinational gene therapy and photothermal therapy (PTT) of cancer cells. Seed-mediated synthesized gold nanorods were modified with GX1 peptide-modified amine-termi-nated generation 3 poly(amidoamine) dendrimers via Au-S bond. The obtained GX1 modified dendrimer-stabilized Au NRs (Au NR@PAMAM-GX1) are performed as a gene delivery vector to gene (FAM172A) for computed tomography (CT) imaging, thermal imaging, photothermal therapy (PTT) and gene therapy of Colon cancer cells (HCT-8 cells).Results: We find that Au NR @ PAMAM-GX1 can specifically deliver FAM172A to cancer cells with excellent transfection efficiency. The HCT-8 cells treated with the Au NR@PAMAM-GX1/FAM172A under laser irradiation have a viability of 20.45%, which is much lower than the survival rate of other single-mode PTT treatment or single-mode gene therapy. In addition, animal experiment results confirm that Au NR@PAMAM-GX1/FAM172A complexes can achieve tumor thermal imaging, PTT and gene therapy after tail vein injection.Conclusion: The synthesized Au NR@PAMAM-GX1 is a potential nanoplatform for tumor imaging and treatment.
Influence of Tibetan Plateau On The North American Summer Monsoon Precipitation
Authors: Wen Qin , Han Zixuan , Yang Hajun , Cheng Jianbo , Liu Zhengyu , Liu Jian 
Published: March 2021

Abstract
It has been well known that the uplift of the Tibetan Plateau (TP) can significantly enhance the Asian monsoon. Here, by comparing the sensitivity experiments with vs without the TP, we find that TP uplift can also increase the precipitation of North American Summer Monsoon (NASM), with atmosphere teleconnection accounting for 6% and oceanic dynamical process accounting for another 6%. Physically, TP uplift generates a stationary Rossby wave train traveling from Asian continent to the North Atlantic region, resulting in an anomalous high-pressure over tropical-subtropical North Atlantic. The anomalous subtropical high enhances the low level southerly winds, forcing an anomalous upward motion over North American monsoon (NAM) region and then an increased summer precipitation there. In addition, TP uplift enhances the Atlantic meridional overturning circulation, which reduces the meridional temperature gradient and leads to a northward shift of Hadley Cell over eastern Pacific-Atlantic section. The latter shifts the convection center northward to 10°N and further increases the NASM precipitation. The enhanced NASM precipitation can also be understood by the northward shift of Intertropical Convergence Zone. Our study implies that the changes of NAM climate can be affected by not only local process but also remote forcing, including the Asian highland.
Diagnosis of Advanced Cervical Cancer, Missed Opportunities?
Authors: Mattern Jérémie , Letendre Irène , Sibiude Jeanne , Pénager Cécile , Jnifen Asma , Souare Fatoumata , Ayel Sophie , Nguyen Thuy , Mandelbrot Laurent 
Published: March 2021

Abstract
Background
Cervical cancer is common worldwide but despite the existence of primary and secondary prevention strategies, the survival rate is decreasing in France. This survival rate is impacted by the increasing proportion of advanced-stage cancer. Our objective was to determine the factors associated with a diagnosis of advanced-stage cervical cancer in an urban population in France
Methods
A retrospective study was conducted on all consecutive records of patients diagnosed with cervical cancer between January 2006 and December 2018 in a single center in Paris. The data collected were demographic characteristics, medical and gynecological history, circumstances of diagnosis, diagnostic and therapeutic management. The patients were divided into two groups according to the FIGO 2018 stage at diagnosis: group A stages Ia 1 to Ib2 and group B advanced stages Ib3 a to IV.
Results
From 2006 to 2018, among 96 patients who were diagnosed with cervical cancer, 25 (26%) were in group A and 71 (74%) in group B. Women in group B had less frequently received regular gynecological care than in group A (36.9% vs 84.2%, p < 0.001) and a fewer had Pap test screening in the previous 3 years (30.4% vs 95.0%, p < 0.001). Parity greater than 3 was more frequent in group B (69.6% vs 42.9%, p = 0.031). The diagnosis was made during a routine examination or cervical smear in only 9.23% and 16.18% respectively in group B, vs 60 % of cases in 45.82% of cases in group A (p < 0.001 and p = 0.003). Vaginal bleeding was observed in 85.29% in group B vs 36% in group A (p < 0.001). Histological type was squamous cell carcinoma 87.32% of group B and 56% of group A (p < 0.001).
Conclusion
Diagnosis of cervical cancers at advanced stages was mostly in women who did not benefit from the recommended screening. Universal access to screening is necessary for the prevention and early treatment of cervical cancer.
Health risk assessment and bioaccumulation of heavy metals in Procambarus clarkii from six provinces of China
Authors: Mo Aijie , Huang Yangyang , Gu Zemao , Liu Chunsheng , Wang Jianghua , Yuan Yongchao 
Published: March 2021

Abstract
Contamination with heavy metals in wild red swamp crayfish (Procambarus clarkii) from 7 different geographical areas in six provinces of China (Hubei, Hunan, Jiangxi, Anhui, Jiangsu, and Shandong) was evaluated. Concentrations of chromium (Cr), arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) in the abdominal muscle, gonad, and hepatopancreas were determined by inductively coupled plasma mass spectrometry (ICP-MS) and Atomic Fluorescence Spectrometer (AFS). Except for the Cd content in hepatopancreas, the contents of selected heavy metals in three different tissues were significantly lower than the proposed limits provided by United States Environmental Protection Agency (USEPA). The maximum accumulations of Cd and Pb were in hepatopancreas, while the maximum accumulation of As was in gonad, and the maximum accumulations of Hg and Cr were in abdominal muscle. The highest contents of Cr, Hg, and Pb were all detected in Dongting Lake, Hunan, which was consistent with the trend of the metal pollution index (MPI). Risk value of the target hazard quotient (THQ) was below 1.0, suggesting that the intake of selected heavy metals through crayfish consumption would not pose a significant health risk to consumers.
Application of Improved Incision in the Protection of Superficial Temporal Artery.
Authors: Yan Renchun , Fang Xinyun 
Published: March 2021

Abstract
Objective: To explain the clinical importance of protecting the superficial temporal artery and introduce a method of protecting the superficial temporal artery.Methods: This study retrospectively analyzed the clinical data of 75 emergency patients undergoing frontotemporal craniotomy. The data was divided into traditional incision group and improved incision group according to the different surgical incision methods.Results: There were 38 cases in the traditional incision group, 13 of which had superficial temporal artery injury. Only 8 cases (21%) underwent the anatomical separation of superficial temporal artery during the operation. Whereas there were 37 cases in the improved incision group, with none showing superficial temporal artery injury. Conclusion: No strong consciousness of protecting the superficial temporal artery was shown in the clinical emergency surgery. The improved incision is a simple and easy way to protect the superficial temporal artery.
Waterbed leakage drives EU ETS emissions: COVID-19, the Green Deal &amp; the recovery plan
Authors: Bruninx Kenneth , Ovaere Marten 
Published: March 2021

Abstract
Because of the EU ETS' cancellation policy, its fixed cap or waterbed is punctured, meaning that shocks and overlapping policies can change cumulative carbon emissions, i.e., waterbed leakage. This paper explains the mechanisms behind waterbed leakage and quantifies the effect of COVID-19, the European Green Deal, and the recovery stimulus package on cumulative EU ETS emissions and allowance prices. We find that the negative demand shock of the pandemic has limited effect on the EU ETS price and is almost completely translated into lower carbon emissions, because of high waterbed leakage. Increasing the 2030 reduction target to -55% increases the price of allowances to 67 euro/ton CO2 today and decreases carbon emissions in the period 2020-2050 by around 16.3 GtCO2 or 42% of the cumulative cap under current policies. These results are robust to significant changes in allowance demand triggered by overlapping policies in the period 2021-2031.
Scleral Fixation Using a Hydrophilic Four-haptic Lens and Polytetrafluoroethylene Suture: A Phase I Clinical Trial
Authors: Junqueira Natacha , Chaves Leandro , Poli-Neto Omero , Scott Ingrid , Jorge Rodrigo 
Published: March 2021

Abstract
Purpose: To assess the safety of scleral fixation using Akreos AO60 IOL and Gore-Tex suture. Methods: Prospective evaluation of 20 patients who underwent scleral fixation of Akreos AO60 with Gore-Tex. Patients presenting with aphakia or dislocated IOL without capsular support were enrolled in the study. Main outcome measures included visual acuity, endothelial cell density, and postoperative complications over 6 months of follow-up.Results: Mean ± SD uncorrected logMAR visual acuity improved from 1.92 ± 0.23 (20/1600 Snellen equivalent) preoperatively to 0.80 ± 0.56 (20/125) post-surgery (p < 0.001). Mean ± SD BCVA logMAR was 0.43 ± 0.23 preoperatively and 0.37 ± 0.24 (20/50) post-surgery (p = 0.312). Exposure of suture occurred in 8/20 (40%) eyes over the 6 months of follow-up. The mean ± SD endothelial cell density was 1,740.50 ± 522.92 cells/mm2 and 1,187.19 ± 493.00 cells/mm2 (p < 0.001) pre and postoperatively, respectively. Mean ± SD postoperative spherical equivalent was -1.12 ± 1.50D. Postoperative complications included hypotony in 15% of the patients, ocular hypertension and transient vitreous hemorrhage in 10%, and retinal detachment and transient lens opacification in 5%. Conclusion: Scleral fixation with an Akreos AO60 and Gore-Tex appears safe. However, caution must be taken regarding suture exposure, and scleral flaps can be a technique to reduce the risk of this complication. Phase II studies are needed.