bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of the Calcitonin Gene‐Related Peptide Monoclonal Antibody Galcanezumab Pharmacokinetics and Capsaicin‐Induced Dermal Blood Flow in Healthy Subjects
Authors: Fiedler‐Kelly Jill , Raddad Eyas , de Hoon Jan , Ludwig Elizabeth A. , Passarell Julie , Kielbasa William , Collins Emily C. 
Published: March 2021

AbstractGalcanezumab, a humanized monoclonal antibody targeting calcitonin gene‐related peptide, was recently approved for migraine prophylaxis. The pharmacokinetic/pharmacodynamic (PK/PD) relationship between galcanezumab concentration and inhibition of capsaicin‐induced dermal blood flow (CIDBF) was evaluated using first‐in‐human data following 6 single subcutaneous doses (1 to 600 mg) or multiple (4) 150‐mg doses every 2 weeks in 7 cohorts (7 actively treated subjects and 2 placebo‐treated healthy subjects). Galcanezumab pharmacokinetics were best described by a 1‐compartment model with delayed first‐order absorption/linear elimination. Apparent estimates (between‐subject variability) of clearance, volume of distribution, absorption rate constant, and lag time were 0.0106 L/h (27%CV), 11.2 L (21%CV), 0.0192 h–1 (89%CV), and 0.202 hours, respectively. Estimated elimination half‐life was about 30 days. An effect compartment link model described the concentration‐effect relationship; estimated maximum inhibitory effect was 70.5%, and 50% maximum inhibitory effect concentration (IC50) was 1060 ng/mL. Galcanezumab showed dose‐ and concentration‐dependent potent and durable inhibition of CIDBF. Simulated effect compartment concentrations were maintained above IC50 after 12 weeks of dosing. Near‐maximal CIDBF inhibition occurred with 150 mg biweekly for 12 weeks lasting ≥24 weeks or with ≥30 mg every 2 weeks or 195 mg every 13 weeks. Quantitative modeling of galcanezumab PK/PD supported dose selection for the phase 2 proof‐of‐concept study.
A weakly supervised tooth‐mark and crack detection method in tongue image
Authors: Weng Hui , Li Lei , Lei Huangwei , Luo Zhiming , Li Candong , Li Shaozi 
Published: March 2021

AbstractTongue diagnosis is one of the primary clinical diagnostic methods in Traditional Chinese Medicine. Recognizing the tooth‐marked tongue and the crackled tongue plays an essential role in evaluating the status of patients. Previous methods mainly focus on identifying whether a tongue image is a tooth‐marked tongue (cracked tongue) or not, while cannot provide more details. In this study, we propose a weakly supervised method for training the tooth‐mark and crack detection model by leveraging fully bounding‐box level annotated and coarse image‐level annotated tongue images. The proposed model is extended from the YOLO object detection model, and we add several classification branches for recognizing the tooth‐marked tongue and cracked tongue. The classification branch aims to predict the coarse label for both coarse‐labeled data and fully annotated data. The detection branch is used to locate the position of tooth marks and cracks from the fully annotated data. Finally, we utilize a multitask loss function for training the model. Experimental results on a challenging tongue image dataset demonstrate the effectiveness of our proposed weakly supervised method.
Application of near infrared spectroscopy for determination of relationship between crop year, maturity group, location, and carbohydrate composition in soybeans
Authors: Singh Mukti , Bowman Michael J. , Berhow Mark A. , Price Neil P. J. , Liu Sean X. 
Published: March 2021

AbstractOver 40,000 discrete samples of soybeans (Glycine max) were obtained from locations around the United States grown during the years 2013–2018. The samples were ground and scanned on near infrared spectrometer (NIRS). The carbohydrate composition—sucrose, raffinose family oligosaccharides, total soluble sugar composition, total insoluble sugars, and total uronic acids—was determined by prediction using NIRS calibration models. Multiple linear regression models were developed using about 2,300 soybean samples and an additional 700 samples for validation with NIRS scans and carbohydrate composition measurements using analytical methods. Relationship between carbohydrates and the agronomic traits of the soybeans were determined. It was found that crop year, maturity group, and location had a significant effect on the carbohydrate composition of soybeans. NIRS is an accurate, rapid, and nondestructive method to determine carbohydrate composition in large numbers of soybeans.
A Bayesian resampling approach to estimate the difference in effect sizes in consumer social responses to CSR initiatives versus corporate abilities
Authors: Marquina Percy , Charles Vincent 
Published: March 2021

AbstractWe expand previous analyses and advance our understanding of the difference in the impact on consumer purchasing behaviour between pursuing corporate social responsibility (CSR) initiatives and improving corporate abilities. To this aim, a Bayesian bootstrapping simulation is applied to selected consumer samples for 123 homogeneous choice‐based conjoint studies. We develop a simulation‐based approach to estimate the empirical distributions of effect sizes under two Bayesian bootstrap resampling schemes. This approach permits us to evaluate the results for two predefined classifications: Foote‐Cone‐Belding (FCB) and gender. The results indicate that females exhibit higher concern for CSR initiatives. Furthermore, we found that managers can exploit the classification of their product in the FCB grid and obtain more efficient consumer responses by implementing strategies focused on certain attributes. This is the first application of the FCB grid to identify differences in consumer responses across different products with different levels of rational consideration and involvement.
Harmonics mitigation approach by using pulse‐doubling circuit in the AC–DC rectifier
Authors: Abdollahi Rohollah , Badfar Ehsan 
Published: March 2021

SummaryIn this research, a novel pulse‐doubling circuit (PDC) is employed to upgrade the 28‐pulse rectifier to the efficient 56‐pulse rectifier. The main objective of this research is to reduce the power kVA rating. In the autotransformer with a 14‐phase polygon structure, the kVA rating is approximately 39.5% of the load power. Since the pulse‐doubling method is utilized, the rectifier with 56 pulses has benefited from a simpler structure. With a comparison to the other rectifiers, the harmonic mitigation is the clearest feature of the proposed rectifier. According to the experimental and theoretical results, in the proposed rectifier with 56 pulses, the input current THD is less than 3%. Finally, the volume and cost of the proposed rectifier with 56 pulses show a notable reduction. In other words, the proposed rectifier is an economical choice for most sectors of the industry.
Clinical characteristics of endocrinopathies in Chinese patients with hereditary haemochromatosis
Authors: Wu Han , Yu Miao , Xiao Cheng , Zhang Qian , Xiao Xinhua 
Published: March 2021

AbstractAimsHereditary haemochromatosis (HH) is a genetic disorder characterised by systemic iron overload and can lead to end‐organ failure. However, very few data on this disorder, especially those on endocrine gland involvement in Chinese populations, are currently available. This study aimed to analyse the clinical features of endocrinopathies in patients with HH to generate concern among endocrinologists and improve the management of this disorder.Materials and MethodsChinese patients with HH‐related endocrine dysfunction were enrolled at Peking Union Medical College Hospital from January 2010 to December 2018. All clinical data were analysed and summarised.ResultsA total of six patients were enrolled in this study, comprising five men and one woman; the average age was 36.5 ± 13.3 years. Mean serum ferritin concentration was 4508.8 ± 1074.3 ng/ml, and median transferrin saturation was 97.9% (96.6%–110.0%). Endocrine gland involvement associated with HH included the pancreas (5/6 patients), the adenohypophysis (5/6 patients) and the bones (1/6 patients); secondary endocrinopathies consisted of diabetes mellitus, hypogonadism, adrenal insufficiency and osteoporosis. Based on phlebotomy and iron chelation therapy, five patients were treated with exogenous insulin preparations, and three patients were treated with exogenous sex hormone replacement therapy. The clinical symptoms of five patients improved, although one patient died of hepatic encephalopathy and multiple organ failure.ConclusionsHH can cause multiple endocrinopathies. The possibility of HH should be carefully considered in patients with endocrine gland dysfunctions and concomitant elevated serum ferritin levels. Endocrine gland function should also be assessed and followed up in patients with a clear diagnosis of HH.
Deep reefs are not refugium for shallow‐water fish communities in the southwestern Atlantic
Authors: Medeiros Aline P. M. , Ferreira Beatrice P. , Alvarado Fredy , Betancur‐R Ricardo , Soares Marcelo O. , Santos Bráulio A. 
Published: March 2021

Abstract

The deep reef refugia hypothesis (DRRH) predicts that deep reef ecosystems may act as refugium for the biota of disturbed shallow waters. Because deep reefs are among the most understudied habitats on Earth, formal tests of the DRRH remain scarce. If the DRRH is valid at the community level, the diversity of species, functions, and lineages of fish communities of shallow reefs should be encapsulated in deep reefs.

We tested the DRRH by assessing the taxonomic, functional, and phylogenetic diversity of 22 Brazilian fish communities between 2 and 62 m depth. We partitioned the gamma diversity of shallow (<30 m) and deep reefs (>30 m) into independent alpha and beta components, accounted for species’ abundance, and assessed whether beta patterns were mostly driven by spatial turnover or nestedness.

We recorded 3,821 fishes belonging to 85 species and 36 families. Contrary to DRRH expectations, only 48% of the species occurred in both shallow and deep reefs. Alpha diversity of rare species was higher in deep reefs as expected, but alpha diversity of typical and dominant species did not vary with depth. Alpha functional diversity was higher in deep reefs only for rare and typical species, but not for dominant species. Alpha phylogenetic diversity was consistently higher in deep reefs, supporting DRRH expectations.

Profiles of taxonomic, functional, and phylogenetic beta diversity indicated that deep reefs were not more heterogeneous than shallow reefs, contradicting expectations of biotic homogenization near sea surface. Furthermore, pairwise beta‐diversity analyses revealed that the patterns were mostly driven by spatial turnover rather than nestedness at any depth.

Conclusions. Although some results support the DRRH, most indicate that the shallow‐water reef fish diversity is not fully encapsulated in deep reefs. Every reef contributes significantly to the regional diversity and must be managed and protected accordingly.
Phylogeography of sugar kelp: Northern ice‐age refugia in the Gulf of Alaska
Authors: Grant William Stewart , Chenoweth Erica 
Published: March 2021

AbstractMany Northeast (NE) Pacific fishes and invertebrates survived Pleistocene glaciations in northern refugia, but the extent that kelps survived in northern areas is uncertain. Here, we test the hypothesis that populations of sugar kelp (Saccharina latissima) persisted in the Gulf of Alaska during ice‐age maxima when the western margin of the Cordilleran ice sheet covered coastal areas around the NE Pacific Ocean. We estimated genetic diversities within and phylogeographical relationships among 14 populations along 2,800 km in the NE Pacific and Bering Sea with partial sequences of mitochondrial DNA 5′‐cytochrome oxidase subunit I (COI, bp = 624, n = 543), chloroplast DNA ribulose‐1,5‐bisphosphate carboxylase large subunit‐3′ (rbcL, bp = 735, n = 514), and 11 microsatellite loci. Concatenated sequences of rbcL and COI showed moderate levels of within‐population genetic diversity (mean h = 0.200) but substantial differences among populations (ΦST = 0.834, p < .0001). Microsatellites showed moderate levels of heterozygosity within populations (mean HE = 0.391). Kelps in the same organellar lineage tended to cluster together, regardless of geographic origins, as indicated in a principal coordinate analysis (PCoA) of microsatellite genotypes. The PCoA also showed evidence of nuclear hybridizations between co‐occurring organellar lineages. Individual admixture plots with population clusters of K = 2, 6, and 9 showed increasing complexity with considerable historical admixture between some clusters. A time‐calibrated phylogeny placed divergences between rbcL‐COI lineages at 1.4 million years at most. The time frames of mutation in the rbcL‐COI lineages and microsatellite population clusters differed among locations. The existence of ancient lineages in the Gulf of Alaska, moderate levels of genetic diversity, and the absence of departures from neutrality are consistent with northern refugia during multiple Croll‐Milankovitch climate cycles in the Pleistocene Epoch.
Embryo ecology: Developmental synchrony and asynchrony in the embryonic development of wild annual fish populations
Authors: Polačik Matej , Vrtílek Milan , Reichard Martin , Žák Jakub , Blažek Radim , Podrabsky Jason 
Published: March 2021

AbstractEmbryo–environment interactions are of paramount importance during the development of all organisms, and impacts during this period can echo far into later stages of ontogeny. African annual fish of the genus Nothobranchius live in temporary pools and their eggs survive the dry season in the dry bottom substrate of the pools by entering a facultative developmental arrest termed diapause. Uniquely among animals, the embryos (encased in eggs) may enter diapause at three different developmental stages. Such a system allows for the potential to employ different regulation mechanisms for each diapause. We sampled multiple Nothobranchius embryo banks across the progressing season, species, and populations. We present important baseline field data and examine the role of environmental regulation in the embryonic development of this unique system. We describe the course of embryo development in the wild and find it to be very different from the typical development under laboratory conditions. Development across the embryo banks was synchronized within and across the sampled populations with all embryos entering diapause I during the rainy season and diapause II during the dry season. Asynchrony occurred at transient phases of the habitat, during the process of habitat desiccation, and at the end of the dry season. Our findings reveal the significance of environmental conditions in the serial character of the annual fish diapauses.
An empirical test of the bet‐hedging polyandry hypothesis: Female red flour beetles avoid extinction via multiple mating
Authors: Matsumura Kentarou , Miyatake Takahisa , Yasui Yukio 
Published: March 2021

AbstractBet‐hedging via polyandry (spreading the extinction risk of the female's lineage over multiple males) may explain the evolution of female multiple mating, which is found in a wide range of animal and plant taxa. This hypothesis posits that females can increase their fitness via polyandrous mating when “unsuitable” males (i.e., males causing reproductive failure for various reasons) are frequent in the population and females cannot discriminate such unsuitable mates. Although recent theoretical studies have shown that polyandry can operate as a bet‐hedging strategy, empirical tests are scarce. In the present study, we tested the bet‐hedging polyandry hypothesis by using the red flour beetle Tribolium castaneum. We compared female reproductive success between monandry and polyandry treatments when females mated with males randomly collected from an experimental population, including 20% irradiated (infertile) males. In addition, we evaluated geometric mean fitness across multiple generations as the index of adaptability of bet‐hedging traits. Polyandrous females showed a significantly higher egg hatching rate and higher geometric mean fitness than monandrous females. These results strongly support the bet‐hedging polyandry hypothesis.
Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI‐induced hypogonadism?
Authors: Geddes Rastafa I. , Kapoor Amita , Hayashi Kentaro , Rauh Ryan , Wehber Marlyse , Bongers Quinn , Jansen Alex D. , Anderson Icelle M. , Farquhar Gabrielle , Vadakkadath‐Meethal Sivan , Ziegler Toni E. , Atwood Craig S. 
Published: March 2021

AbstractIntroductionHypogonadotropic hypogonadism (HH) is an almost universal, yet underappreciated, endocrinological complication of traumatic brain injury (TBI). The goal of this study was to determine whether the developmental hormone human chorionic gonadotropin (hCG) treatment could reverse HH induced by a TBI.MethodsPlasma samples were collected at post‐surgery/post‐injury (PSD/PID) days ‐10, 1, 11, 19 and 29 from male Sprague‐Dawley rats (5‐ to 6‐month‐old) that had undergone a Sham surgery (craniectomy alone) or CCI injury (craniectomy + bilateral moderate‐to‐severe CCI injury) and treatment with saline or hCG (400 IU/kg; i.m.) every other day.ResultsBoth Sham and CCI injury significantly decreased circulating testosterone (T), 11‐deoxycorticosterone (11‐DOC) and corticosterone concentrations to a similar extent (79.1% vs. 80.0%; 46.6% vs. 48.4%; 56.2% vs. 32.5%; respectively) by PSD/PID 1. hCG treatment returned circulating T to baseline concentrations by PSD/PID 1 (8.9 ± 1.5 ng/ml and 8.3 ± 1.9 ng/ml; respectively) and was maintained through PSD/PID 29. hCG treatment significantly, but transiently, increased circulating progesterone (P4) ~3‐fold (30.2 ± 10.5 ng/ml and 24.2 ± 5.8 ng/ml) above that of baseline concentrations on PSD 1 and PID 1, respectively. hCG treatment did not reverse hypoadrenalism following either procedure.ConclusionsTogether, these data indicate that (1) craniectomy is sufficient to induce persistent hypogonadism and hypoadrenalism, (2) hCG can reverse hypogonadism induced by a craniectomy or craniectomy +CCI injury, suggesting that (3) craniectomy and CCI injury induce a persistent hypogonadism by decreasing hypothalamic and/or pituitary function rather than testicular function in male rats. The potential role of hCG as a cheap, safe and readily available treatment for reversing surgery or TBI‐induced hypogonadism is discussed.
The emotional face of anorexia nervosa: The neural correlates of emotional processing
Authors: Halls Daniel , Leslie Monica , Leppanen Jenni , Sedgewick Felicity , Surguladze Simon , Fonville Leon , Lang Katie , Simic Mima , Nicholls Dasha , Williams Steven , Tchanturia Kate 
Published: March 2021

AbstractSocial–emotional processing difficulties have been reported in Anorexia Nervosa (AN), yet the neural correlates remain unclear. Previous neuroimaging work is sparse and has not used functional connectivity paradigms to more fully explore the neural correlates of emotional difficulties. Fifty‐seven acutely unwell AN (AAN) women, 60 weight‐recovered AN (WR) women and 69 healthy control (HC) women categorised the gender of a series of emotional faces while undergoing Functional Magnetic Resonance Imaging. The mean age of the AAN group was 19.40 (2.83), WR 18.37 (3.59) and HC 19.37 (3.36). A whole brain and psychophysical interaction connectivity approach was used. Parameter estimates from significant clusters were extracted and correlated with clinical symptoms. Whilst no group level differences in whole brain activation were demonstrated, significant group level functional connectivity differences emerged. WR participants showed increased connectivity between the bilateral occipital face area and the cingulate, precentral gyri, superior, middle, medial and inferior frontal gyri compared to AAN and HC when viewing happy valenced faces. Eating disorder symptoms and parameter estimates were positively correlated. Our findings characterise the neural basis of social–emotional processing in a large sample of individuals with AN.
Large‐scale functional network connectivity mediate the associations of gut microbiota with sleep quality and executive functions
Authors: Cai Huanhuan , Wang Chunli , Qian Yinfeng , Zhang Shujun , Zhang Cun , Zhao Wenming , Zhang Tingting , Zhang Biao , Chen Jingyao , Liu Siyu , Zhu Jiajia , Yu Yongqiang 
Published: March 2021

AbstractNetwork neuroscience has broadly conceptualized the functions of the brain as complex communication within and between large‐scale neural networks. Nevertheless, whether and how the gut microbiota influence functional network connectivity that in turn impact human behaviors has yet to be determined. We collected fecal samples from 157 healthy young adults and used 16S sequencing to assess gut microbial diversity and enterotypes. Large‐scale inter‐ and intranetwork functional connectivity was measured using a combination of resting‐state functional MRI data and independent component analysis. Sleep quality and core executive functions were also evaluated. Then, we tested for potential associations between gut microbiota, functional network connectivity and behaviors. We found significant associations of gut microbial diversity with internetwork functional connectivity between the executive control, default mode and sensorimotor systems, and intranetwork connectivity of the executive control system. Moreover, some internetwork functional connectivity mediated the relations of microbial diversity with sleep quality, working memory, and attention. In addition, there was a significant effect of enterotypes on intranetwork connectivity of the executive control system, which could mediate the link between enterotypes and executive function. Our findings not only may expand existing biological knowledge of the gut microbiota‐brain‐behavior relationships from the perspective of large‐scale functional network organization, but also may ultimately inform a translational conceptualization of how to improve sleep quality and executive functions through the regulation of gut microbiota.
Medicaid expansion and the mental health of college students
Authors: Cowan Benjamin W. , Hao Zhuang 
Published: March 2021

AbstractReported mental health problems have risen dramatically among US college students over time, as has treatment for these problems. We examine the effect of state‐level Medicaid expansion following the 2014 implementation of the Affordable Care Act on the diagnosis of mental health conditions, psychotropic prescription drug use, and the mental health status of a national sample of college students. We find that students from disadvantaged backgrounds are more likely to report being on public insurance after 2014 in expansion states relative to non‐expansion states, while more advantaged students do not see this increase. Both diagnosis of common mental health conditions and psychotropic drug use increase following expansion for disadvantaged students relative to advantaged ones, which translates into an elimination of the pre‐expansion gap in these outcomes by family background in expansion states. However, in contrast to some recent work on Medicaid expansion and mental health, we do not find that these changes are associated with improvements in self‐reported mental health status. We also do not find that Medicaid expansion has affected risky health behaviors or academic outcomes.