bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of perinatal factors on platelet indices in late preterm and term newborns
Authors: ÜSTÜN Nuran 
Published: June 2021

Abstract
Aim: This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions.
Materials and Methods: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life.
Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex and maternal hypertension were significantly related to lower PLT (p
Un Ambiente visual integrado de desarrollo para el aprendizaje de programación en robótica
Authors: Ruíz Ramírez Carlos Alejandro , Montoya Quintero Diana María , Jimenez Builes Jovani Alberto 
Published: June 2021

Objetivo: revisar algunos aspectos y características positivas del uso de la robótica en ambientes educativos y describir algunas de las características de los lenguajes de programación utilizados en su implementación. Metodología: se explica como un ambiente de desarrollo implementado mediante el uso de algunas características de computación en la nube, puede ser usado para aplicar robótica en escuelas, colegios y universidades. El entorno de programación combina la programación gráfica utilizando notación de procesos de trabajo (BPM) y programación textual. Resultados: se demostró que se puede hacer una transición gradual de lenguajes visuales a lenguajes de programación textuales, así como las ventajas de aprender estándares que permiten el potenciar el aprendizaje de habilidades en el modelado de procesos.
Conclusiones: se comprobó la capacidad que tienen los entornos de programación diseñados con propósitos educativos para trabajar la robótica en un ambiente cloud computing, reduciendo la brecha que permite pasar de una programación gráfica a una programación textual usando múltiples dispositivos robóticos, en un único escenario de desarrollo.
A Study of the Chinese-English Translation of Culture-specific Items in Publicity Texts of Guangzhou’s Intangible Cultural Heritage
Authors: Zheng Shaohui 
Published: June 2021

Intangible cultural heritage is the core of Guangzhou’s cultural “soft power”. The Chinese-English translation of intangible cultural heritage is an important way to promote Guangzhou’s culture and to arouse the awareness of protecting intangible cultural heritage in the whole society. The culture-specific items in the publicity texts of intangible cultural heritage reflect the charm and heterogeneity of Guangzhou’s culture. This paper proposes that while translating cultural-specific items of Guangzhou’s intangible cultural heritage, in order to ensure that the translation can retain the cultural characteristics of the source language and be understood and accepted by the target language readers, translators should combine the translation strategies of Domestication and Foreignization and flexibly adopt seven methods, i.e., literal translation, literal translation plus transliteration, literal translation plus explanation, transliteration plus explanation, transliteration plus category words, transliteration plus intra-text explanation and transliteration plus free translation. Suggestions are also given aiming to provide reference for the researches and practice of the translation of intangible cultural heritage in Guangzhou and other cities. It is also hoped that this study can provide some implications for pedagogical application and be helpful for those who follow closely the translation of intangible cultural heritage.
The Correlation Between Being Informed on Complementary and Alternative Medicine and Its Reported Use Among Cancer Patients in Yogyakarta
Authors: Sari Ike Wuri Winahyu , Rukmi Dwi Kartika 
Published: June 2021

Background: Previous studies have indicated that the majority of cancer patients have used self-selected Complementary and Alternative Medicine to relieve disease-related symptoms and treatment-related adverse effects untreated by conventional treatment to improve the quality of life. Unfortunately, studies on Complementary and Alternative Medicine use among cancer patients, especially in Yogyakarta, the city with the highest cancer prevalence in Indonesia, are still limited.Objective: This present study aims to identify the correlation between being informed on Complementary and Alternative Medicine and its reported use among cancer patients.Methods: This study was a descriptive correlational study on 75 consenting cancer patients. The respondents were selected using a purposive sampling technique. Data about their Complementary and Alternative Medicine use were collected by administered questionnaires and analyzed using descriptive statistics and bivariate analysis.Results: 25.3% of respondents had used Complementary and Alternative Medicine. Being informed on Complementary and Alternative Medicine and its reported use among cancer patients were significantly correlated (r=0.331; p=0.002).Conclusion: Complementary and Alternative Medicine use among cancer patients was still limited. Health providers need to discuss Complementary and Alternative Medicine use with their patients openly.
Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways
Authors: Meng Yue , Ji Jian , Xiao Xiao , Li Minghan , Niu Shangbo , He Youhua , Tong Guojun , Pan Chenglong 
Published: June 2021

As a kind of chronic inflammatory diseases, Rheumatoid arthritis (RA) has a low cure rate and easy recurrence. It has widely reported that abnormal activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling pathways are associated with the development of RA inflammation. Blocking the inflammatory signaling pathways of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) can delay the development of RA. Ononin is a natural isoflavone glycoside and plays a key role in modulating inflammation related signaling pathways. However, whether Ononin exerts anti-inflammatory effects on RA inflammation remains unknown. In this study, we evaluated the therapeutic effect of Ononin on RA by establishing a tumor necrosis factor α (TNF-α)-induced RA-FLS cell model. Our data confirmed that Ononin could alleviate TNF-α-induced RA-FLS and MH7A cells viability, increase cell apoptosis, decrease the production of pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin 6 (IL-6), and further inhibit the abnormal activation of NF-κB and MAPK pathways. Our results suggested that Ononin could be a potential therapeutic agent for RA.
SATISFAÇÃO PROFISSIONAL DO ENFERMEIRO NO AMBIENTE DA UNIDADE DE TERAPIA INTENSIVA
Authors: Lessa dos Santos Emilenny , Pereira da Silva Cícera Eugênia , Melo de Oliveira Janine , Farias Barros Viviane , Da Silva Barros Romão Cyndi Myrelle , Dos Santos Josefa Jadiane , Barbosa da Silva Mariana 
Published: June 2021

<p>Objetivo: analisar a concepção do enfermeiro acerca da satisfação profissional no âmbito da unidade de terapia intensiva. Metodologia: estudo analítico de abordagem qualitativa, realizado em um hospital universitário do estado de Sergipe. A coleta de dados foi realizada em outubro de 2020, através de entrevistas semiestruturadas com enfermeiros do setor de unidade de terapia intensiva geral, os dados foram analisados mediante Análise de Conteúdo. Resultados: dos depoimentos emergiram as seguintes categorias: o trabalho do enfermeiro nas Unidades de Terapia Intensiva; fatores que interferem na satisfação profissional do enfermeiro no âmbito da UTI e a relação do enfermeiro com a satisfação profissional no ambiente de terapia intensiva durante a pandemia Covid-19. Conclusão: na concepção dos enfermeiros da UTI, a satisfação profissional é um aspecto importante no seu ambiente de trabalho e pode influenciar na prestação da assistência ofertada aos pacientes.</p>
Triple-Blinded Randomized Study to Evaluate the Effect of Acetaminophen and Morphine Sulfate on Pain Relief in MI-patients
Authors: Bakhshaei Mohammad Hossein , Homayounfar Shahram , Roozbahani Behzad , Malekpour Melika , Farhadian Maryam 
Published: June 2021

Background: Myocardial infarction is considered to be the most common symptom of cardiovascular diseases. Regarding the limitation of access to Morphine sulphate as a special drug and complications followed, this study aims to compare the treatment effects of intravenous acetaminophen and morphine sulphate on the reduction of pain in MI patients and to improve the cardiac performance.
Methods: The present study is a triple-blind randomized control trial in which 70 patients were divided into two separated groups and the pain was measured using Visual Analogue Scale. All analysis was done using SPSS Software at the significance level of 5 percent.
Results: 42 patients were male (60%) of whom 20 were in case group and 22 in control group. There were no significant difference between intervention group and control group in terms of VAS score (p = 0.520). The index change of VAS over the time was statistically significant (p=0.001) in intervention and control groups (intra group change). The results of variance analysis with repeated measurements showed that mean differences of Ejection Fraction over time in both groups of intervention and control was not statistically significant (p=0.28).
Conclusion: The findings of this study demonstrate that although Acetaminophen does not have an improved effect on pain control and cardiac performance than Morphine sulphate, it can be still an appropriate alternative for Morphine sulfate due to the lack of destructive effects and its availability.
Molecular Investigation of the Human Adenovirus in Retinoblastoma Patients
Authors: Tabibzadeh Alireza , Naseripour Masood , Karbalaie Niya Mohammad Hadi , Javanmard Davod , Esghaei Maryam 
Published: June 2021

Background and Aims: Retinoblastoma tumors are the most common intraocular malignancy in childhood, leading to death after two years. The Human Adenovirus (HAdV) infection could be critical in the retinoblastoma pathogenesis due to the virus and retinoblastoma 1 interactions. The objective of the current study was to investigate the possible presence of the HAdV genome in the retinoblastoma patient's tumors.
Materials and Methods: In this study, we evaluated the HAdV infection in 96 pathological confirmed retinoblastoma samples. The DNA was extracted from formalin-fixed paraffin-embedded blocks, and the virus infection was assessed using polymerase chain reaction. SPSS version 22 was used for statistical analysis.
Results: The mean age ± SD of the retinoblastoma patients was 28.89 ± 17 months. In addition, the demographic evaluation indicated that 43 (46.7%) of patients were female. The retinoblastoma laterality assessment indicates 87 (90.4%) unilateral and 9 (9.4%) bilateral tumors. Growth pattern analysis indicates endophytic 58 (77.3%), exophytic 8 (10.7%), and 9 (12%) of tumors with mix endophytic and exophytic patterns. The polymerase chain reaction results could not found any evidence of HAdV infection in all 96 formalin-fixed paraffin-embedded samples.
Conclusions: The study results suggest that there is not any association between HAdV infection and retinoblastoma tumors in studied samples. The HAdV infection may not a concern in retinoblastoma pathogenesis. Further investigations are recommended in this field of study.
The impact of BMI, Smoking, Family History and Ala 119 Ser (rs1056827) Polymorphism of CYP1B1*2 Genes with Susceptibility to Prostate Cancer among Iranian Men
Authors: Salmanzade Jamile , Tahmasebi Fard Zahra , Deilami khiabani Zahra 
Published: June 2021

Background and Aims: The genes involved in detoxification and the elimination of toxic metabolites have a vital role in cancer pathogenesis. Also, there is evidence that higher amounts of body fat are associated with increased risks of several cancers. The current study aims to identify the relationship of age, body mass index (BMI), smoking, family history, and polymorphism rs1056827 of CYP1B1 with prostate cancer.
Materials and Methods: A total of 103 patients and 103 healthy men as control groups were enrolled in the current study. The DNAs were extracted using the salting-out method after venesection, and the genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The obtained data were analyzed by SPSS version 23 using X2 statistical tests and logistic regression.
Results: The results showed a significant association between the study groups regarding age, BMI, and family history of the disease (p = 0.024, p = 4.08⨯10-4, and p = 3.58⨯10-19, respectively). Investigation of genetic models except to additive model showed a significant relationship between TT (Ser/Ser) genotype and prostate cancer. It also showed a strong association between this genotype with BMI and family history.
Conclusion: The current study results showed that the carriers of the TT genotype with a high BMI have a higher chance of developing prostate cancer. Further studies in this area will provide stronger results.
Raman Spectroscopic Characterization of Hepatic Differentiation of Mesenchymal Stem Cells
Authors: Arjmand Sareh , Barzegar Aram , Mohammadpour Alemeh , Rezaei Hanieh , Davoodian Nahid , Ghaneialvar Hori , Malekfar Rasoul , Sahebghadam Lotfi Abbas 
Published: June 2021

Background and Aims: Mesenchymal stem cells (MSCs) are a preferred cell source for the generation of hepatocyte-like cells in regenerative medicine. They can be isolated from different sources, including adipose tissues. The Raman spectroscopy approach was evaluated for quick and efficient identification of MSCs differentiation status and a broader perspective on cell differentiation.
Materials and Methods: The human adipose-derived mesenchymal stem cells (hASCs) were differentiated toward hepatocyte-like cells using a well-established method. The cells were cultured on fluorescence-free quartz discs, and the efficiency of differentiation was examined using molecular and biochemical methods. The Raman spectra were recorded at days 1, 7, 14, and 21 of differentiation, and HepG2 was used as a positive control.
Results: The changes in Raman spectra were detected during the sequential stages of differentiation, and the pattern of peaks on the last day of differentiation was remarkably similar to the positive control (HepG2).
Conclusion: Raman spectroscopy showed considerable potential to characterize hepatic differentiation.
Vitamin D Status in Jiroft City Population, South of Iran, 2015-2019
Authors: Kamali Mohadeseh , Shariati Mohammad , Taheri Sarvtin Mehdi 
Published: June 2021

Background and Aims: Vitamin D plays an important role in bone health, cardiovascular health, brain development, immune system regulation, mood regulation, and cancer prevention. This study aimed to evaluate the vitamin D status and the prevalence of vitamin D deficiency in Jiroft city, Kerman Province, south of Iran.
Materials and Methods: In this cross-sectional study, 5243 people were selected by random sampling during 2015-2019. Serum 25 (OH) D level was measured by VIDAS 25-OH vitamin D total testing kits. Levels used for definitions were deficient, D3 < 20 ng/ml; insufficient, D3 20-30 ng/ml; adequate, D3 30-100 ng/ml, and potential toxicity, >100 ng/ml.
Results: The mean of vitamin D was 26.03 ng/ml and 24.19 ng/ml in men and women, respectively (p=0.003). The prevalence of vitamin D deficiency was 41.55% and 51.7% in men and women, respectively. A significant relationship was seen between age and level of vitamin D (p=0.001).
Conclusions: The results of our study showed that vitamin D deficiency is common among the general population, especially in women in Jiroft city, Kerman Province, south of Iran. Serious plans are needed to improve the status of vitamin D in the people living in this region.
Soluble Expression and Purification of Q59L Mutant L-asparaginase in the Presence of Chaperones in SHuffle™ T7 strain
Authors: Biglari Goliloo Elham , Tollabi Abdolnabi , Zarei Jaliani Hossein 
Published: June 2021

Background and Aims: Q59L mutant of L-asparaginase enzyme from Escherichia coli (E. coli) has been introduced with lower side effects. This version of the enzyme might have potential applications in the treatment of leukemia patients. We utilized SHuffle T7 strain of E. coli, to produce the mutant enzyme in the presence of chaperone molecules.
Materials and Methods: Q59LAsp gene was cloned into pET28a expression vector, and two strains of E. coli (BL21 DE3 and SHuffle T7 strains) were used to produce recombinant protein. In parallel, PG-Tf2 plasmid was cloned into the same strains, and the effect of trigger factor chaperone and groELS chaperonines was studied. The his-tagged recombinant protein was expressed and purified using nickel affinity chromatography. The amount of recombinant protein which is produced in each condition was determined and compared.
Results: The amount of soluble recombinant protein was enhanced in the presence of chaperones in both strains of E. coli. SHuffle T7 strain produced more soluble recombinant protein in the soluble state than BL21 DE3 strain. So the best condition for the production of soluble recombinant Q59L mutant protein was the use of PG-Tf2 plasmid in the SHuffle T7 strain.
Conclusion: Application of the new strain SHuffle T7, with chaperones simultaneously showed better results in the production of Q59L mutant version of L-Asparaginase.
A Study on the Presence of Aflatoxin M1 in Cow’s Milk in Jiroft
Authors: Kamali Mohadeseh , Seyyedi Seyyedeh Sedigheh , Taheri Sarvtin Mehdi 
Published: June 2021

Background and Aims: Cow's milk is a daily staple food for many individuals that can be contaminated with many toxins such as aflatoxin M1 (AFM1). AFM1 is a chemical form of the aflatoxin B1 produced by some species of Aspergillus genus like A. ochraceus, A. flavus, A. nomius, and A. parasiticus that can contaminate feed and forage cattle. This toxin enters into the milk after eating contaminated feed by cows. AFM1 can cause various dangerous diseases such as cancer and immune deficiency in humans. The present study is aimed to investigate the level of AFM1 in cow's milk in Jiroft, Kerman Province, Iran.
Materials and Methods: A total of 90 cow’s milk samples were collected in spring and summer 2019 from available stores in Jiroft city. Enzyme-linked immunosorbent assay was used to measure AFM1 in all cow’s milk samples.Results: In the present study, AFM1 was found in 88 (97.8%) milk samples with a range of 0.2-90.62 ppt (mean, 20.07±24.46 ppt). AFM1 concentrations exceeded 50 ppt (maximum tolerance level of AFM1 in the European Union) was seen in 12 (13.3%) samples.
Conclusions: The results of this study showed the presence of AFM1 in cow's milk in Jiroft city. So, in this region, many people are exposed to dangerous diseases such as cancer due to the consumption of milk contaminated with AFM1.
Exploration of Malang Traditional Art for Junior High School Learning Materials
Authors: Rahmanto Kelik Desta , Iriaji . , Rini Denik Ristya , Prasetyo Abdul Rahman 
Published: June 2021

Malang has many kinds of traditional art and music and it is important that young people are aware of their local art and music as part of their cultural identity. The purpose of this research was to explore Malang traditional art and music which could be used as learning materials for junior high school students, especially for art and culture subject matter. This research used a qualitative approach. Data were collected through interviews, field observation and documentation analysis. The results showed that there is traditional art in Malang which can be used for this purpose, namely pottery from Penanggungan sub-district and batik from Celaket sub-district, which both use traditional elements. This research also identified the traditional music called Malangan Macapat which is different to Central Java Macapat. The conclusion was that these forms of Malang traditional art and music can be developed as learning materials for art and culture subject matter for junior high school students.

Keywords: education, art, music, learning materials, traditional
A distinção massa e contável na gramática Rikbaktsa (Macro-Jê)
Authors: Dellai Érica Milani , Ern Vitória Maria Jasper , Silva Léia de Jesus , Oliveira Roberta Pires de , Rachadel Beatriz Martins , Souza Bianca Maria de 
Published: June 2021

Neste artigo investigamos a distinção massivo-contável na língua Rikbaktsa (Macro-Jê). Partimos do questionário de Lima & Rothstein (2020), o qual procuramos responder levantando os dados em um acervo inédito do qual já dispúnhamos, na pouca literatura sobre a língua (Boswood 1971, 1978; SIL 2007; Silva 2011), e em uma elicitação de dados com um falante nativo. A análise mostrou que há morfologia de plural e que ela não se combina com nomes de massa. Nomes que denotam átomos estáveis se combinam diretamente com numerais. Para serem contados, nomes de substância exigem a presença de sintagmas de medidas. Esses são indícios de que a língua em questão pode ser caracterizada como uma língua de número marcado (Chierchia 2010, 2015), mesmo que haja alguns nomes de massa que podem ser contados diretamente. Em nenhuma das quinze línguas apresentadas em Lima & Rothstein (2020) há relato de um morfema especializado para marcar massa. Chacon (2012) afirma que o Kubeo (Tukano-Oriental) exibe um demonstrativo de massa. Esse é também o caso em Rikbaktsa, mas nesta língua o demonstrativo na ‘isto’, que seleciona nomes massivos, se espalha pela gramática: aparece com marca de terceira pessoa no pronome pessoal a-na, com proformas interrogativas e em construção atributiva. Este estudo contribui, portanto, para uma melhor compreensão da distinção massivo-contável através das línguas e da gramática desta língua minoritária.
COVID-19 AS WAKE-UP CALL TO RECONSIDER THE MAINSTREAM FINANCIAL PRACTICES: ISLAMIC FINANCE PERSPECTIVE
Authors: Nour Aldeen Khaled 
Published: June 2021

This paper aims to present recommendations that can immune a conventional financial system against the global crisis, particularly the Covid-19 pandemic crisis from the lens of Islamic finance. This paper contends that Islamic finance is a relatively immune financial system comparing to the mainstream financial system by eliminating Riba and considering only asset-backed transactions as fruitful ones. This paper begins with the conceptual investigation of the literature on the principles of Islamic finance. The literature’s origins include primary sources (Quraan and hadith) and secondary sources (books, journals, and online resources). This paper is only conceptual and does not aim to examine the issues or theories empirically. The article will be useful to develop hypotheses for future research, especially in Islamic finance. Islamic concepts will of interest, especially for countries that adopt the conventional financial system. This paper will also be useful in the introduction for both Islamic and conventional finance practitioners alike. This paper provides a conceptual model to substitute the dominant conventional economics. Highlights the necessary steps to reconsider the conventional financial system. Islamic finance can mitigate the impact of COVID-19 on the economies mainly because of the PLS (profit-loss sharing) system and Islamic ethics in financial transactions. The paper shows its originality in substance and makes a unique contribution to the literature on systems and ethics by emphasizing Islamic finance practices approaching an effective alternative to conventional finance. Keywords: Islamic finance, mainstream finance, Covid-19JEL Classifications: G00, Y9