bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abundance and distribution of microplastics in water and sediment of Baiyangdian Lake, Northern China
Authors: Fang Yanyan 
Published: November 2021

Abstract
Microplastics (MPs) have been found in all environment matrices and have become an issue of concern worldwide. In this study, Baiyangdian Lake in Northern China was investigated for the presence of MPs (0.45 µm–5 mm) in sediment and at different water depths. MPs were found at 1,000–20,000 pieces/m3 (average 9,595) in water and at 400–2,200 pieces/kg (average 1,023) in sediment. Since the implementation of pollution abatement measures, visible MPs have been nearly eliminated; the MPs found in this study were mainly in the micrometer range, with no more than 3–5 pieces greater than 1 mm per sample. The main forms of MPs were fibrous and fragmented, and the main components were polyamide, polyethylene, and polypropylene. MPs found in water near a garbage transfer station showed the following abundance of MPs: surface water < middle water < bottom water. The sediment contained a higher amount of MP fragments, indicating that the historical transfer and disposal of garbage was a main source of plastic deposition in this area. There was a high content of fibrous MPs in surface water, while the abundance of fragmented MPs increased with the depth of water. The main sources of MPs in the study area were residential activities, local plastic factories, and the treated effluent from a sewage treatment plant.
Hemorrhagic Transformation in Patients With Large-artery Atherosclerotic Stroke Is Associated With Gut Microbiota and LPS-TLR4 Signaling Pathway
Authors: Huang Qin , Wei Min-Ping , Feng Xian-Jing , Yu Fang , Liao Di , Liu Ze-Yu , Luo Yun-Fang , Zhao Ting-Ting , Tu Ru-Xin , Huang Qing , Liu Yun-Hai , Jian xia 
Published: November 2021

Abstract
Objective: Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of gut microbiota is an important feature of stroke, and some special bacteria combined with bacterial metabolites may contribute to HT pathogenesis. we aimed to study the relationship between gut microbiota and HT of large-artery atherosclerotic stroke. Methods: From May-2020 through September-2021, the blood and fecal samples in patients with acute first-ever ischemic stroke and not undergoing intravenous thrombolysis or endovascular were obtained on admission, and gut microbiota was assessed by 16s ribosomal ribonucleic acid (rRNA) sequence. Stroke that developed HT (n=15) were compared to those without HT (n=17) and healthy controls (n=16). We also examined the key components of lipopolysaccharide (LPS) pathway: LPS, LPS-binding protein (LBP), and solube CD14 (sCD14). The role of gut microbiota in HT was evaluated using experimental stroke model. Results: We observed that bacterial diversity was decreased in both HT and non-HT group compared to the healthy controls. The patients of ischemic stroke that developed HT had differential composition of gut microbiota, in particular, an increase in the relative abundance and diversity of members belonging to the Enterobacteriaceae family. Plasma LPS and LBP levels were higher in HT group compared to non-HT group. The concentrations of LPS, LBP and sCD14 were associated with increased abundance of Enterobacteriaceae. In experimental study, the antibiotics treatment diminished HT-induced increase in the levels of LPS and LBP as well as upregulated expression of Toll-like receptor 4 (TLR4) and NF-κB in colon tissue. Transplant of microbiota from HT rats triggered higher level of LPS, LBP and sCD14 in plasma and increased expression of TLR4 and NF-κB in colon tissue.Conclusion: Stroke patients who developed with HT exhibit an obvious change in gut microbiota and LPS-induced inflammatory response. This suggests that maintaining a balance of gut microbiota may be an important factor in preventing HT after stroke.
Elastic Settlement Analysis of Rigid Footings Relying On The “Characteristic Point” Concept
Authors: Pantelidis Lysandros 
Published: November 2021

Abstract
In the present paper, the problem of finding the location of the so-called “characteristic point” of flexible footings is revisited. As known, the settlement at the characteristic point, is equal to the uniform settlement of the respective rigid footing. The cases of infinitely long strips and circular footings are studied fully analytically. For the case of rectangular footings, analytical results (for flexible footings) are compared with the respective numerical results (for rigid footings) obtained from 3D finite element analysis (210 cases were examined). As shown, the location of the characteristic point may greatly deviate from the well-known values reported in the literature, as it strongly depends on the thickness and Poisson’s ratio value of the compressible medium. For rectangular footings this location also depends on their aspect ratio, L/B. The location of the characteristic point with respect to the center of footing for the various cases examined is given in tabular form. Strain influence area values (Aj=ρjEs/qB) are also given for the convenient calculation of the settlement (ρj) of footings, especially the rigid, rectangular ones; q is the uniform surcharge of footing and Es the soil modulus.
Focused Ultrasound and RadioTHERapy for Non-Invasive Palliative Pain Treatment in Patients with Bone Metastasis: A Study Protocol for the Three Armed Randomized Controlled FURTHER-trial
Authors: Bartels Marcia , Ferrer Cyril , Bos Clemens , Bartels Lambertus , Boomsma Martijn , Slotman Derk , Phernambucq Erik , Nijholt Ingrid , Morganti Alessio , Siepe Giambattista , Buwenge Milly , Gruell Holger , Bratke Grischa , Yeo Sin Yuin , Blanco Roberto , Minn Heikki , Huhtala Mira , Napoli Alessandro , de Felice Francesca , Catalano Carlo , Bazzocchi Alberto , Gasperini Chiara , Campanacci Laura , Galendi Julia , Mueller Dirk , Braat Manon , Moonen Chrit , Verkooijen Helena 
Published: November 2021

Abstract
Background

Cancer Induced Bone Pain (CIBP), caused by bone metastases, is a common complication of cancer and strongly impairs quality of life (QoL). External Beam RadioTherapy (EBRT) is the current standard of care for treatment of CIBP. However, approximately 45% of patients have no adequate pain response after EBRT. Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) may improve pain palliation in this patient population.
Methods/design:

The FURTHER trial is an international multicenter, three-armed randomized controlled trial. A total of 216 patients with painful bone metastases will be randomized in a 1:1:1 ratio to receive EBRT only, MR-HIFU only, or combined treatment with EBRT followed by MR-HIFU. During a follow-up period of six months, patients will be contacted at eight time points to retrieve information about their level of pain, QoL and the occurrence of (serious) adverse events. The primary outcome of the trial is pain response at 14 days after completion of treatment. Secondary outcomes include pain response at 14 days after trial enrolment, pain scores (daily until the 21st day, weekly until the 6th week and monthly until the 6th month), toxicity, adverse events, QoL, and survival. Cost-effectiveness and cost-utility analysis will be conducted.
Discussion

The FURTHER trial aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU – alone or in combination with EBRT – compared to EBRT to relieve CIBP. The trial will be performed in six hospitals in four European countries, all of which are partners in the FURTHER consortium.
Trial registration:

The FURTHER trial is registered under the Netherlands Trials Register number NL71303.041.19 and ClinicalTrials.gov registration number NCT04307914. Date of trial registration is 13-01-2020.
Transmen Individuals Have Hyperandrogenism Related Metabolic Changes Compared Ciswomen: Case Controlled Study
Authors: Erel Pınar , Elbasan Onur , Yorguner Neşe , İmre Eren , ÜSTAY Özlem 
Published: November 2021

Abstract
Introduction

: This study aims to evaluate metabolic parameters and hormonal profiles of transmen individuals who are referred from psychiatry outpatient clinic, compared to natal women.
Method

This study is designed as a single-center observational cohort study. Seventy drug-naive female to male transgender individuals (FtoM) and 34 healthy natal women for the control group were included. Hormone profile and metabolic parameters were measured and compared between the two groups.
Results

Sixteen of the 70 FtoM individuals meet Rotterdam criteria and are diagnosed with PCOS (22,85%), on the other hand in 4 individuals in the control group meet the criteria (11,7%). Although there wasn't any significant difference between the two groups weight and BMI; total testosterone, triglyceride, FAI, androstenedione, 17-OH progesterone, muscle strength, HOMA-IR levels were significantly higher in the transmen group and HDL levels were significantly higher in the control group (p values 0.001, 0.007, 0.013, 0.011, 0.001, 0.004 respectively.)
Conclusion

This is the first case-controlled study that compared anthropometric, metabolic, and endocrinological parameters of transmen individuals with cis women. In our study, we showed that even when PCOS patients were excluded, hyperandrogenemia continues in these individuals compared to cis women. It is clear that transmen individuals have higher androgen levels which may have been the reason for increased muscle strength, insulin resistance, and dyslipidemia compared to natal women. But the main reason for hyperandrogenism in drug-naïve transmen individuals is still not known and more comprehensive further studies are needed.
Energy and Heat for Medium-sized Cities in a Temperate Climate From a Small Nuclear Reactor and Solar Panels
Authors: Janczyszyn Jerzy , Jaskólski Marcin 
Published: November 2021

Abstract
The article discusses the possibilities of using a system consisting of small nuclear reactors, solar collectors and a heat accumulator in future carbon-free conditions. Kraków (Poland) was chosen as an example of a city supplied with electricity, and heat from the discussed system. The demand for electricity and heat was estimated, possible technical solutions were proposed in an approximate manner and monthly balances of electricity and heat were calculated. It was found impossible to meet the energy needs by using only renewable sources in specific conditions of moderate and season-dependent intensity values of sun and wind. The only and efficient option that is able to cover the city's demand for electricity and heat is a nuclear power plant, consisting, for example, of NuScale nuclear units in combination with solar collectors and a properly selected heat accumulator. Fifty MWel reactors were considered, but a new version of the NuScale modular reactor with a modular capacity of 77 MWel is also briefly shown.
Longitudinally Extensive Transverse Myelitis (LETM) in COVID-19 Infection, A Case-Report
Authors: Cutsem Jean-Christophe Van , Lamon Ann-Sophie , Belleghem Vincent Van , Vancaester Evelien 
Published: November 2021

Abstract
IntroductionSince the COVID-19 pandemic, a growing number of central nervous system (CNS) complications in patients with COVID-19 have been reported. Isolated, longitudinally extensive transverse myelitis (LETM), is a unique presentation of CNS involvement. The limited reports, its diverse clinical manifestations and the possible long-term consequences make the reporting crucial to further our understanding of those syndromes occurring in COVID-19 positive patients.Case PresentationA 63-year old male consulted the emergency department after a sudden onset of gait ataxia, a one-week history of paresthesia progressing from the feet to the midsternal area and urinary. He tested positive on a SARS-CoV-2 RNA RT-PCR nasopharyngeal swab two days prior to the onset of his symptoms. Neurological examination showed a sensory level at T7 with symmetrically reduced fine touch, vibration, proprioception and furthermore an ataxic gait was observed. Cerebrospinal fluid on day one of admission showed pleocytosis, predominantly neutrophils, elevated protein count and normal glucose level and IgG. MRI of the spinal cord revealed a diffusely increased signal intensity involving the near-complete spinal cord, from the brainstem to level T12, fitting the diagnosis of LETM. ConclusionThe few cases of transverse myelitis in association with COVID-infection are believed to have an immune-mediated postinfectious mechanism. In this case however, parainfectious direct viral invasion of the spinal cord is far more likely because of a neutrophilic predominance in CSF and a short timespan between infection and symptoms. It could provide more clues that the SARS-CoV-2 is acutally capable of causing direct neurotoxic effects.
Dynamic Pollution Emission Prediction Method of a Combined Heat and Power System Based on the Hybrid CNN-LSTM Model and Attention Mechanism
Authors: Wan Anping , Yang Jie , Chen Ting , Jinxing Yang , Li Ke , Qinglong Zhou 
Published: November 2021

Abstract
The prediction of pollution emission from a combined heat and power (CHP) system is very important for the production regulation and emergency response of a power system. The composition and structure of the CHP equipment are complex, and the production process is cumbersome. The fuel chemical reaction of the pulverized coal in the boiler represents a highly nonlinear and strongly interrelated process that is strongly affected by external environmental factors, which causes a certain level of volatility and uncertainty. In this study, a pollution emission prediction method of CHP systems based on feature engineering and a hybrid deep learning model is proposed. Feature engineering performs multi-step preprocessing on the original data, refines the correlation factors, and removes redundant variables. The hybrid deep learning model has a multi-variable input and is established by combining the convolutional neural network-long short-term memory network with the attention mechanism. The case study is conducted on the collected actual dataset. The influence of the prediction target periodicity on the prediction results is analyzed seasonally to verify the effectiveness of the hybrid model. The results show that the root mean square error of the proposed method is less than one, and the error is reduced compared to the other basic methods, which proves the superiority of the proposed pollution emission prediction method over the existing methods.
Agroturismo: cultura e identidade agregando renda no espaço rural
Authors: Zandonadi Beatriz Mauro , Freire Ana Lucy Oliveira 
Published: November 2021

O espaço rural brasileiro vem passando por mudanças importantes ao longo das últimas três décadas. Novas atividades econômicas se destacam num cenário que gera significativas transformações sociais e culturais sobre a realidade rural do país, incluso nesse quadro o estado do Espírito Santo, onde sobressai o exemplo do município de Venda Nova do Imigrante, localizado na região centro serrana, dotado de clima ameno, relevo pontuado de serras e com forte influência dos imigrantes italianos que colonizaram a região. A base de sua economia é a agricultura, porém o município vem ganhando notoriedade numa nova atividade: o agroturismo. Essa modalidade de turismo surgiu como uma forma de diversificar e aumentar a renda, além de possibilitar a permanência das famílias no espaço rural, especialmente após o declínio de produções agrícolas tradicionais, como o café. O agroturismo vem se mostrando uma maneira de recuperar e ressaltar os traços culturais típicos; manter a identidade tradicional dos produtores; dinamizar o espaço local; sendo ainda uma forma de inserir os ganhos com as novas atividades na economia urbana. Esse artigo visa discutir e analisar as novas as atividades ligadas ao agroturismo, assim como estas podem contribuir no desenvolvimento da economia rural, mantendo e reativando conhecimentos e heranças culturais que ajudam na manutenção da identidade dos produtores locais, além de pontuar alguns cuidados a serem tomados para que tais atividades não percam seu propósito principal.
Agente versus estrutura no modelo multidimensional-reflexivo: estudo de caso de uma organização hoteleira do tipo cama café
Authors: Matos Mariana Bueno de Andrade , Matos Beatriz Gondim , Barbosa Maria de Lourdes de Azevedo 
Published: November 2021

O presente estudo teve como objetivo compreender o sistema organizacional de um meio de hospedagem do tipo Cama e Café a partir da relação agência/estrutura, ou seja, da relação entre as pessoas e a estrutura organizacional da empresa. A análise dessa relação buscou avaliar como esses elementos (agente e estrutura) se influenciam a partir do modelo Multidimensional-Reflexivo (ALVES, 2004). Para tanto, buscou-se fundamentação na teoria de Weber, nomeadamente, os conceitos de Ação Social, Tipo Ideal e Estruturas puras de Dominação. Como metodologia, realizou-se um estudo de caso de natureza qualitativa de um meio de hospedagem do tipo Cama e Café. A coleta de dados se deu por entrevistas semiestruturadas, e as informações foram tratadas com a técnica de análise do discurso. Com o resultado da pesquisa verificou-se que existe a supremacia do agente sobre a estrutura na empresa e o subtipo em que se enquadra o ‘cama e café’ é o organizacional-administrativo patriarcal reformista, ou seja, em que o líder da empresa têm autonomia administrativa e é livre da tradição, e, assim, promove mudanças já que a coordenação e o controle são centrados nele.
A importância da hospitalidade e qualidade dos serviços na hotelaria hospitalar
Authors: Oliveira da Silva Cavalcante Islaine Cristiane , Fernandes Ferreira Lissa Valéria 
Published: November 2021

A hotelaria hospitalar é caracterizada como um serviço do turismo médico, envolvendo infraestrutura presente na hotelaria convencional. A qualificação e a humanização complementam-se através da hospitalidade. Ser bem acolhido e receber atenção são itens básicos no processo de envolvimento do cliente com qualquer empreendimento/localidade. Teve-se como objetivo geral de pesquisa analisar os instrumentos de mensuração da qualidade dos serviços de hospitais da Cidade do Natal, sendo eles privados e públicos, identificando a relevância dessa estratégia no que diz respeito ao controle e organização dos serviços. Para fins metodológicos o estudo classifica-se com uma abordagem qualitativa, exploratório e descritivo com análise bibliográfica. Como resultados, pode-se constatar a importância significativa dos instrumentos de mensuração de qualidade nos hospitais para uma melhor resposta quanto aos serviços prestados. Pode-se analisar também a hospitalidade na hotelaria hospitalar como de relevância no processo de melhoria do paciente, pois contribui para o seu bem-estar durante sua estada no hospital. O cliente define-se como a chave de todo o processo dos serviços e sua opinião sobre o produto faz-se de importância significativa para obtenção de resultados positivos. A contínua análise da percepção dos clientes ainda permanece sendo uma das melhores estratégias na gestão dos serviços.
PRÁTICAS PARA APRIMORAR O ENSINO NA DISCIPLINA DE PEDOLOGIA
Authors: Batista Ivaniza Sales 
Published: November 2021

A Pedologia é uma ciência de suma importância na compreensão, análise, interpretação e planejamento do espaço geográfico. Diante disso, torna-se relevante que o ensino da Pedologia proporcione condições reais de aprendizado e construção do conhecimento. Objetivou-se avaliar a importância da utilização de atividades práticas para aprimorar o ensino em Pedologia. A metodologia adotada restringiu-se à aplicação de questionários e a realização de uma avaliação das experiências adquiridas em sala de aula. Os resultados obtidos demonstram o quão relevante se constitui o desenvolvimento de atividades práticas como essa. Os alunos puderam analisar em campo e em laboratório os atributos morfológicos dos solos e discutir as peculiaridades de cada um deles, fazendo inferências sobre os diferentes ambientes de onde as amostras de solo analisadas foram coletadas. Por fim, foi comprovado a partir da análise dos questionários que os discentes demonstraram aprender com maior facilidade os conteúdos teóricos trabalhados em sala de aula, em campo e com a ida ao laboratório. Essas práticas capacita-os a analisar das particularidades dos solos e suas inter-relações com o meio, de modo, a aguçar o olhar técnico/profissional dos mesmos.
Withdrawal Notice: Development of Itraconazole Loaded Transethosomes for Improved Transdermal Delivery
Authors: Mishra Koushlesh Kumar 
Published: November 2021

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Relationship Between Illness Representations and Symptoms of Internet Gaming Disorder Among Young People: Cross-Lagged Model
Authors: Yang Xue , Wong Kei Man , She Rui , Zhao Chengjia , Ding Nani , Xu Huihui , Tu Xiaolian , Lai Xinyi , Zhang Guohua 
Published: November 2021

Background
The common-sense model of illness suggests that mental representations of health threats may affect one’s behavioral reactions to them and health status. Internet gaming disorder is a newly defined mental disorder. Illness representations of internet gaming disorder may affect one’s risk of internet gaming disorder. In turn, symptoms of internet gaming disorder may affect one’s perceptions of the disorder.

Objective
This study aimed to investigate the relationships between illness representations and symptoms of internet gaming disorder in college students.

Methods
A 1-year longitudinal study was conducted with a convenience sample of Chinese college students (n=591; 342/591, 57.9% female).

Results
Of the participants, 10.1% (60/591) and 9.1% (54/591) were classified as having probable internet gaming disorder at baseline (T1) and follow-up (T2), respectively. The correlations between some dimensions of illness representations regarding internet gaming disorder (ie, consequence, timeline, personal control, treatment control, and concern) at T1 and symptoms of internet gaming disorder at T2 and between symptoms of internet gaming disorder at T1 and the dimensions of illness representations at T2 (ie, consequence, timeline, personal control, and emotional response) were statistically significant. The cross-lagged model fit the data well ((χ2/df=2.28, comparative fit index=.95, root mean square error of approximation=.06) and showed that internet gaming disorder at T1 was positively associated with unfavorable illness representations at T2.

Conclusions
Individuals with more severe symptoms of internet gaming disorder had more pessimistic perceptions about the disorder. Such cognitive perceptions may affect one’s emotional and behavioral reactions towards the disorder (eg, greater levels of depression and low self-control intention) and should be modified by educational programs and psychological interventions.