bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of glaucoma surgery on visual field progression in open‐angle glaucoma considering the floor effect
Authors: Schlatter Andreas , Rauchegger Teresa , Schmid Eduard , Teuchner Barbara 
Published: October 2021

AbstractPurposeThe aim of this retrospective analysis was to investigate whether trabeculectomy (TRAB) and XEN® Gel Stent implantation (XEN) – both filtrating surgery techniques – can slow down the deterioration of visual field (VF) parameters considering the floor effect, which could lead to a misestimation of pre‐ and postoperative VF rate of progression (ROP).MethodsIncluded in this study were patients with open‐angle glaucoma, who underwent either TRAB or XEN® gel stent implantation and who had at least three VF tests before and after surgery, over an observation period of 13 years. The annual ROP of the mean defect (MD) and the square root of loss variance (sLV) were calculated with two different censoring thresholds: by censored regression and by ordinary least squares regression (OLSR). In addition, the diagnostic range of sLV was calculated.Results48 eyes of 39 glaucoma patients were included in the study. The annual rate of MD progression was significantly reduced by filtering surgery when calculating the yearly ROP using OLSR (p = 0.006) and by censoring values exceeding a precalculated cut‐off of 14.20 dB (p = 0.041) and a cut‐off from the literature of 15.00 dB (p = 0.028). On average, the MD was impacted by a significant floor effect of 14.20 dB (95% CI: 12.83‐15.56), corresponding to 17.7/59 absolute defects or 29.9% of the whole VF. When applying both OLSR and censored regression, the annual rate of sLV progression did not show a significant difference. The sLV showed a diagnostic boundary at a MD of 15.78 dB.ConclusionThis study shows that filtering surgery can reduce the progression of VF in patients with open‐angle glaucoma, especially those whose disease develops aggressively. This is valid even if the floor effect in advanced cases is compensated by censored regression. On average, the ROP of MD is affected by a significant floor effect at about 29.9% absolute loss of the whole VF.
Performance of creatinine‐based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
Authors: Delanaye Pierre , Björk Jonas , Courbebaisse Marie , Couzi Lionel , Ebert Natalie , Eriksen Björn O. , Dalton R. Neil , Dubourg Laurence , Gaillard Francois , Garrouste Cyril , Grubb Anders , Jacquemont Lola , Hansson Magnus , Kamar Nassim , Lamb Edmund J. , Legendre Christophe , Littmann Karin , Mariat Christophe , Melsom Toralf , Rostaing Lionel , Rule Andrew D. , Schaeffner Elke , Sundin Per‐Ola , Berg Ulla B. , Åsling‐Monemi Kajsa , Selistre Luciano , Åkesson Anna , Larsson Anders , Bökenkamp Arend , Pottel Hans , Nyman Ulf 
Published: October 2021

AimThe Cockcroft‐Gault (CG) creatinine‐based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over‐ or underdosing.MethodsIn a cross‐sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification‐of‐Diet‐in‐Renal‐Diseases (MDRD), Chronic‐Kidney‐Disease‐Epidemiology (CKD‐EPI), Lund‐Malmö‐Revised (LMR) and European‐Kidney‐Function‐Consortium (EKFC) equations. Validation focused on bias, imprecision and accuracy (percentage of estimates within ±30% of mGFR, P30), overall and stratified for mGFR, age and body mass index at mGFR <60 mL/min, as well as classification in mGFR stages.ResultsThe CG equation performed worse than the other equations, overall and in mGFR, age and BMI subgroups in terms of bias (systematic overestimation), imprecision and accuracy except for patients ≥65 years where bias and P30 were similar to MDRD and CKD‐EPI, but worse than LMR and EKFC. In subjects with mGFR <60 mL/min and at BMI 18.5‐25 kg/m2, all equations performed similarly, and for BMI < 18.5 kg/m2 CG and LMR had the best results though all equations had poor P30‐accuracy. At BMI ≥ 25 kg/m2 the bias of the CG increased with increasing BMI (+17.2 mL/min at BMI ≥ 40 kg/m2). The four more recent equations also classified mGFR stages better than CG.ConclusionsThe CG equation showed poor ability to estimate GFR overall and in analyses stratified for mGFR, age and BMI. CG was inferior to correctly classify the patients in the mGFR staging compared to more recent creatinine‐based equations.
Exploring the intellectual structure of research in codes of ethics: A bibliometric analysis
Authors: Delgado‐Alemany Rafael , Blanco‐González Alicia , Díez‐Martín Francisco 
Published: October 2021

AbstractIn this study, we map the intellectual structure of the code of ethics research field by means of a co‐citation bibliometric analysis. To date, this type of analysis is absent from the literature on codes of ethics. Previous literature reviews have clarified definitions, studied contents, and analyzed the effectiveness of codes of ethics. However, the qualitative nature of these reviews does not resolve fundamental issues for understanding the evolution and status of this research field. This study contributes to the field by providing a bibliometric review in which the main research areas, sources of knowledge, trends, interrelationships, and dissemination paths of the domain are shown. Our findings reveal four main lines of research in the field of codes of ethics: corporate agent behavior with respect to codes of ethics, content analysis, effectiveness of codes of ethics, and employees’ attitudes toward codes of ethics. We also show that the study of the contents of codes of ethics is the main connecting bridge in this area of knowledge. Finally, we identify upcoming research topics in the field such as cultural change, the defensive nature of codes of ethics, and the application of organizational theories to code analysis.
Relationship between physical activity and health in individuals with intellectual disability
Authors: Faust Caroline , Morin Diane 
Published: October 2021

Accessible summary
Individuals with intellectual disability are less physically active and have more health problems than the general population.
This paper is about information gathered from family members on health and physical activity levels of people with intellectual disability.
Health of people with intellectual disability do not differ according to the frequency and the intensity of physical activity.
Research is important for people with intellectual disability because our results helped better understand the need for developing physical activity guidelines specifically for this population and strategies to encourage them to be more physically active.

AbstractBackgroundThe frequency and intensity of physical activity are directly related to health in the general population. However, to our knowledge, no study has looked at that relationship in people with intellectual disability.MethodThe aim of this study was to determine whether there were differences in the health of 407 people with intellectual disability according to the frequency and intensity of physical activity. The method involved cross‐sectional study of secondary data.FindingsResults showed that the ability to express pain, number of orthopaedic and physiotherapy consultations, body mass index and percentage of psychosis/schizophrenia diagnoses differed with the frequency and intensity of physical activity.ConclusionOther studies are needed to learn more about physical activity factors that could improve the health of people with intellectual disability.
Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis
Authors: Sehl‐Ewert Julia , Schwaiger Theresa , Schäfer Alexander , Hölper Julia E. , Klupp Barbara G. , Teifke Jens P. , Blohm Ulrike , Mettenleiter Thomas C. 
Published: October 2021

AbstractHerpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, its pathogenesis is still only poorly understood. Although several mouse models of predominantly herpes simplex virus 1 (HSV‐1) infections mimic different crucial aspects of HSE, central questions remain unanswered. They comprise the specific temporofrontal tropism, viral spread within the central nervous system (CNS), as well as potential molecular and immunological barriers that drive virus into latency while only rarely resulting in severe HSE. We have recently proposed an alternative mouse model by using a pseudorabies virus (PrV) mutant that more faithfully represents the striking features of human HSE: temporofrontal meningoencephalitis with few severely, but generally only moderately to subclinically affected mice as well as characteristic behavioral abnormalities. Here, we characterized this animal model using 6‐ to 8‐week‐old female CD‐1 mice in more detail. Long‐term investigation over 6 months consistently revealed a biphasic course of infection accompanied by recurring clinical signs including behavioral alterations and mainly mild meningoencephalitis restricted to the temporal and frontal lobes. By histopathological and immunological analyses, we followed the kinetics and spatial distribution of inflammatory lesions as well as the underlying cytokine expression in the CNS over 21 days within the acute phase of infection. Affecting the temporal lobes, the inflammatory infiltrate was composed of lymphocytes and macrophages showing a predominantly lymphocytic shift 15 days after infection. A strong increase was observed in cytokines CXCL10, CCL2, CCL5, and CXCL1 recruiting inflammatory cells to the CNS. Unlike the majority of infected mice, strongly affected animals demonstrated extensive temporal lobe edema, which is typically present in severe human HSE cases. In summary, these results support the validity of our animal model for in‐depth investigation of HSE pathogenesis.
Identification of RET fusions in a Chinese multicancer retrospective analysis by next‐generation sequencing
Authors: Shi Minke , Wang Weiran , Zhang Jinku , Li Bobo , Lv Dongxiao , Wang Danhua , Wang Sizhen , Cheng Dezhi , Ma Tonghui 
Published: October 2021

AbstractFusion of RET with different partner genes has been detected in papillary thyroid, lung, colorectal, pancreatic, and breast cancer. Approval of selpercatinib for treatment of lung and thyroid cancer with RET gene mutations or fusions calls for studies to explore RET fusion partners and their eligibility for RET‐based targeted therapy. In this study, RET fusion patterns in a large group of Chinese cancer patients covering several cancer types were identified using next‑generation sequencing. A total of 44 fusion patterns were identified in the study cohort with KIF5B, CCDC6, and ERC1 being the most common RET fusion partners. Notably, 17 novel fusions were first reported in this study. Prevalence of functional RET fusions was 1.05% in lung cancer, 6.03% in thyroid cancer, 0.39% in colorectal cancer, and less than 0.1% in gastric cancer and hepatocellular carcinoma. Analysis showed a preference for fusion partners in different tumor types, with KIF5B being the common type in lung cancer, CCDC6 in thyroid cancer, and NCOA4 in colorectal cancer. Co‐occurrence of EGFR mutations and RET fusions with rare partner genes (rather than KIF5B) in lung cancer patients was correlated with epidermal growth factor receptor‐tyrosine kinase inhibitor resistance and could predict response to targeted therapies. Findings from this study provide a guide to clinicians in determining tumors with specific fusion patterns as candidates for RET targeted therapies.
Infant vocalizing and phenotypic outcomes in autism: Evidence from the first 2 years
Authors: Plate Samantha , Yankowitz Lisa , Resorla Leslie , Swanson Meghan R. , Meera Shoba Sreenath , Estes Annette , Marrus Natasha , Cola Meredith , Petrulla Victoria , Faggen Aubrey , Pandey Juhi , Paterson Sarah , Pruett John R. , Hazlett Heather , Dager Stephen , St. John Tanya , Botteron Kelly , Zwaigenbaum Lonnie , Piven Joseph , Schultz Robert T. , Parish‐Morris Julia ,   IBIS Network
Published: October 2021

AbstractInfant vocalizations are early‐emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)‐ and high (HR)‐risk for ASD (HR‐ASD = 23, female = 3; HR‐Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR‐ASD infants produced fewer vocalizations than HR‐Neg infants. From 6 to 24 months, HR‐Neg infants demonstrated steeper vocalization growth compared to HR‐ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD.
Mono‐allelic loss of YTHDF3 and neurodevelopmental disorder: clinical features of four individuals with 8q12.3 deletions
Authors: Terkelsen Thorkild , Brasch‐Andersen Charlotte , Illum Niels , Busa Tiffany , Missirian Chantal , Chandler Kate , Holden Simon T. , Jensen Uffe Birk , Fagerberg Christina R. 
Published: October 2021

AbstractThe YTH domain family member 3 gene (YTHDF3) encodes a reader of the abundant N6‐methyladenosine (m6A) modification of eukaryotic mRNA, which plays an essential role in regulating mRNA stability and is necessary to achieve normal development of the central nervous system in animal models. YTHDF3 has not previously been implicated in Mendelian disease despite a high probability of loss of function intolerance and statistical evidence of enrichment for gene‐disruptive de novo variants in large‐scale studies of individuals with intellectual disability and/or developmental delay. We report four individuals with deletion of 8q12.3, deletion size 1.38–2.60 Mb, encompassing YTHDF3, three of them were de novo, and in one case, the inheritance was unknown. Common features of the individuals (age range, 4–22 years) were developmental delay and/or intellectual disability. Two individuals underwent squint surgery. We suggest that haploinsufficiency of YTHDF3 causes a neurodevelopmental disorder with developmental delay and intellectual disability of variable degree.
Phylogeny of gracillariid leaf‐mining moths: evolution of larval behaviour inferred from phylogenomic and Sanger data
Authors: Li Xuankun , St Laurent Ryan , Earl Chandra , Doorenweerd Camiel , van Nieukerken Erik J. , Davis Donald R. , Johns Chris A. , Kawakita Atsushi , Kobayashi Shigeki , Zwick Andreas , Lopez‐Vaamonde Carlos , Ohshima Issei , Kawahara Akito Y. 
Published: October 2021

AbstractGracillariidae is the most taxonomically diverse cosmopolitan leaf‐mining moth family, consisting of nearly 2000 named species in 105 described genera, classified into eight extant subfamilies. The majority of gracillariid species are internal plant feeders as larvae, creating mines and galls in plant tissue. Despite their diversity and ecological adaptations, their phylogenetic relationships, especially among subfamilies, remain uncertain. Genomic data (83 taxa, 589 loci) were integrated with Sanger data (130 taxa, 22 loci), to reconstruct a phylogeny of Gracillariidae. Based on analyses of both datasets combined and analyzed separately, monophyly of Gracillariidae and all its subfamilies, monophyly of the clade “LAMPO” (subfamilies: Lithocolletinae, Acrocercopinae, Marmarinae, Phyllocnistinae, and Oecophyllembiinae) and relationships of its subclade “AMO” (subfamilies: Acrocercopinae, Marmarinae, and Oecophyllembiinae) were strongly supported. A sister‐group relationship of Ornixolinae to the remainder of the family, and a monophyletic leaf roller lineage (Callicercops Vári + Parornichinae) + Gracillariinae, as sister to the “LAMPO” clade were supported by the most likely tree. Dating analyses indicate a mid‐Cretaceous (105.3 Ma) origin of the family, followed by a rapid diversification into the nine subfamilies predating the Cretaceous–Palaeogene extinction. We hypothesize that advanced larval behaviours, such as making keeled or tentiform blotch mines, rolling leaves and galling, allowed gracillariids to better avoid larval parasitoids allowing them to further diversify. Finally, we stabilize the classification by formally re‐establishing the subfamily ranks of Marmarinae stat.rev., Oecophyllembiinae stat.rev. and Parornichinae stat.rev., and erect a new subfamily, Callicercopinae Li, Ohshima and Kawahara to accommodate the enigmatic genus Callicercops.
‘When I open it, I have to drink it all’: Push and pull factors shaping domestic alcohol consumption during the COVID‐19 pandemic UK Spring 2020 lockdown
Authors: Conroy Dominic , Nicholls Emily 
Published: October 2021

AbstractIntroductionThe closure of licensed venues during the COVID‐19 pandemic meant that most alcohol has been consumed at home during lockdown periods in the UK, a phenomenon that remains under‐researched despite the public health implications.MethodsThis article draws on a study consisting of online semi‐structured interviews and focus groups with 20 UK drinkers, conducted between the first and second 2020 UK lockdowns. The study aimed to explore changing and enduring UK drinking practices within home spaces during the pandemic.ResultsOur findings illuminate specific ways in which assemblages and contextual factors may come together to encourage or mitigate against the consumption of any (or excessive) volumes of alcohol at home during the lockdown. For example, the physical presence of alcohol bottles may both encourage consumption (e.g. compulsion to finish an open bottle of wine) and cue reflection on one's drinking (through the potentially confronting presence of empty bottles after domestic drinking). We also highlight the significance of the home as a space separate from—and different to—public drinking spaces.Discussion and ConclusionsWith the increasing normalisation of domestic drinking during a global pandemic, this paper illuminates several factors that may encourage or curtail domestic alcohol consumption and invites us to consider the importance of assemblages, space and context. Such findings have wider applicability; for example, consideration of specific (and perhaps unique) push and pull factors of home spaces could inform future alcohol policy, health promotion messages and how guidance around ‘moderation’ or risky drinking is communicated.
Sensory stimulation via the visual, auditory, olfactory and gustatory systems can modulate mood and depression
Authors: Canbeyli Resit 
Published: October 2021

AbstractDepression is one of the most common mental disorders, predicted to be the leading cause of disease burden by the next decade. There is great deal of emphasis on the central origin and potential therapeutics of depression whereby the symptomatology of depression has been interpreted and treated as brain generated dysfunctions filtering down to the periphery. This top‐down approach has found strong support from clinical work and basic neuroscientific research. Nevertheless, despite great advances in our knowledge of the aetiology and therapeutics of depression, success in treatment is still by no means assured. As a consequence, a wide net has been cast by both clinicians and researchers in search of more efficient therapies for mood disorders. As a complementary view, the present integrative review advocates approaching mood and depression from the opposite perspective: a bottom‐up view that starts from the periphery. Specifically, evidence is provided to show that sensory stimulation via the visual, auditory, olfactory, and gustatory systems can modulate depression. The review shows how—depending on several parameters—unisensory stimulation via these modalities can ameliorate or aggravate depressive symptoms. Moreover, the review emphasises the bidirectional relationship between sensory stimulation and depression. Just as peripheral stimulation can modulate depression, depression in turn affects—and in most cases impairs—sensory reception. Furthermore, the review suggests that combined use of multisensory stimulation may have synergistic ameliorative effects on depressive symptoms over and above what has so far been documented for unisensory stimulation.
Low‐salinity transitions drive abrupt microbial response to sea‐level change
Authors: Whittle Alex , Barnett Robert L. , Charman Dan J. , Gallego‐Sala Angela V. 
Published: October 2021

AbstractThe salinisation of many coastal ecosystems is underway and is expected to continue into the future because of sea‐level rise and storm intensification brought about by the changing climate. However, the response of soil microbes to increasing salinity conditions within coastal environments is poorly understood, despite their importance for nutrient cascading, carbon sequestration and wider ecosystem functioning. Here, we demonstrate deterioration in the productivity of a top‐tier microbial group (testate amoebae) with increasing coastal salinity, which we show to be consistent across phylogenetic groups, salinity gradients, environment types and latitude. Our results show that microbial changes occur in the very early stages of marine inundation, presaging more radical changes in soil and ecosystem function and providing an early warning of coastal salinisation that could be used to improve coastal planning and adaptation.
Modified particle swarm optimization based magnetic resonance imaging analysis for identification of risk factors tissue damage incidence
Authors: Ke Ji , Wang Shufa , Li Jiangchun , Liu Quan 
Published: October 2021

AbstractThis study was to analyse the risk factors of unstable patella and the incidence of tissue damage (TD) with magnetic resonance imaging (MRI) image under the modified particle swarm optimization (MPSO). In this study, 45 patients with patella instability who visited hospital from 1 November 2018 to 28 September 2020 were selected as the experimental group (group E), and 45 volunteers with healthy knee joints were recruited as the control group (group C). MRI images under MPSO were to evaluate the four groups of related indicators (trochlear groove angle, trochlear groove depth, trochlear surface ratios, and Insall‐Salvati index) of unstable patella in the two groups and count the incidence of TD caused by unstable patella. Comparison of four indicators revealed that there was an obvious difference in the data of the two groups. The abnormal rate of patients with unstable patella in the group E was much higher than that of the group C, and the difference was statistical (p < 0.05). The incidences of trochlea dysplasia and high patella accounted for 88.9% and 57.8% in group E and accounted for 4.4% and 3.2% in the group C, respectively, showing statistically obvious differences (p < 0.05). The incidence of patella cartilage TD, thigh cartilage TD, lateral meniscus TD, medial meniscus TD, patella medial retinaculum TD, patella lateral retinaculum TD, patellar ligament damage, and joint effusions were 14.5%, 11.45%, 50.38%, 49.62%, 10.69%, 16.03%, 9.16%, and 79.39%, respectively in the patients with unstable patella in the group E. In short, trochlear dysplasia and high patella were risk factors for unstable patella, and unstable patella was one of the risk factors for multiple TDs of the knee joint. This study provided a new research basis for the early treatment of unstable patella.