bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of manual therapy on pain, physical function, and nerve conduction studies in carpal tunnel syndrome patients: a systematic review and meta-analysis
Authors: Jiménez-del-Barrio Sandra , Cadellans-Arróniz Aida , Ceballos-Laita Luis , Estébanez-de-Miguel Elena , López-de-Celis Carles , Bueno-Gracia Elena , Pérez-Bellmunt Albert 
Published: December 2021

Abstract
Aim of the study

Systematic review and meta-analysis to assess the effectiveness of manual therapy in improving carpal tunnel syndrome (CTS) symptoms, physical function, and nerve conduction studies.

Method
MEDLINE, Web of Science, SCOPUS, Cochrane Library, TRIP database, and PEDro databases were searched from the inception to September 2021. PICO search strategy was used to identify randomized controlled trials applying manual therapy on patients with CTS. Eligible studies and data extraction were conducted independently by two reviewers. Methodology quality and risk of bias were assessed by PEDro scale. Outcomes assessed were pain intensity, physical function, and nerve conduction studies.

Results
Eighty-one potential studies were identified and six studies involving 401 patients were finally included. Pain intensity immediately after treatment showed a pooled standard mean difference (SMD) of − 2.13 with 95% confidence interval (CI) (− 2.39, − 1.86). Physical function with Boston Carpal Tunnel Syndrome Questionnaire (BCTS-Q) showed a pooled SMD of − 1.67 with 95% CI (− 1.92, − 1.43) on symptoms severity, and a SMD of − 0.89 with 95% CI (− 1.08, − 0.70) on functional status. Nerve conduction studies showed a SMD of − 0.19 with 95% CI (− 0.40, − 0.02) on motor conduction and a SMD of − 1.15 with 95% CI (− 1.36, − 0.93) on sensory conduction.

Conclusions
This study highlights the effectiveness of manual therapy techniques based on soft tissue and neurodynamic mobilizations, in isolation, on pain, physical function, and nerve conduction studies in patients with CTS.
Inanspruchnahme von Unterstützungsangeboten in Familien mit einem psychisch belasteten Elternteil
Authors: Schunke Annika , Reim Julia , Lux Ulrike , Walper Sabine 
Published: December 2021

Zusammenfassung
Hintergrund
Kinder psychisch erkrankter Eltern sind vielfach mit familialen Belastungen konfrontiert und haben ein erhöhtes Risiko, selbst an einer psychischen Störung zu erkranken. Präventionsangebote auf Eltern- und Kindebene haben entsprechend hohe Relevanz. Wenig Beachtung in der Forschung fand bislang die Frage, inwieweit therapeutische und beratende Unterstützungsangebote für psychisch belastete Eltern auch der gesundheitlichen Versorgung ihrer Kinder zugutekommen.

Fragestellung
Die vorliegende Studie untersucht eltern- und kindbezogene Prädiktoren der Inanspruchnahme von therapeutischen und familienbezogenen Unterstützungsangeboten bei Eltern mit selbstberichteter psychischer Belastung. Zusammenhänge zur Inanspruchnahme von Kinder- und Jugendtherapie, auch in Abhängigkeit von der kindlichen psychischen Gesundheit, werden geprüft.

Material und Methode
Ausgehend von 844 Eltern mit 1146 Kindern im Alter von 7 bis 16 Jahren, die in den Wellen 11 und 12 des pairfam-Panels befragt wurden, umfasst die Stichprobe der Hauptanalysen 161 Kinder, deren Elternteil über Depressionssymptome oder eine psychische Erkrankung berichtete. Angaben zur Inanspruchnahme von Therapie und weiteren Angeboten stammen von dem Elternteil, Angaben zur psychischen Gesundheit der Kinder von diesen selbst.

Ergebnisse
Etwa ein Drittel der Eltern mit selbstberichteter psychischer Belastung nimmt eine Therapie in Anspruch. Hierbei werden häufiger auch weitere Angebote für Familien und Kinder genutzt. Selbstberichtete Verhaltensauffälligkeiten der Kinder haben jedoch keinen weiteren Effekt auf ihre Versorgungslage.

Schlussfolgerung
Die Befunde sprechen für eine unzureichende Versorgungslage von auffälligen Kindern psychisch belasteter Eltern, auch dann, wenn die Eltern selbst in Behandlung sind.
Functional results of endoscopic arytenoid abduction lateropexy for bilateral vocal fold palsy
Authors: Rovó László , Matievics Vera , Sztanó Balázs , Szakács László , Pálinkó Dóra , Wootten Christopher T. , Pfiszterer Péter , Tóbiás Zoltán , Bach Ádám 
Published: December 2021

Abstract
Purpose
Endoscopic arytenoid abduction lateropexy (EAAL) is a reliable surgical solution for the minimally invasive treatment of bilateral vocal fold palsy (BVFP), providing a stable airway by the lateralization of the arytenoid cartilages with a simple suture. The nondestructive manner of the intervention theoretically leads to higher regeneration potential, thus better voice quality. The study aimed to investigate the respiratory and phonatory outcomes of this treatment concept.

Methods
61 BVFP patients with significant dyspnea associated with thyroid/parathyroid surgery were treated by unilateral EAAL. Jitter, Shimmer, Harmonics to Noise Ratio, Maximum Phonation Time, Fundamental frequency, Voice Handicap Index, Dysphonia Severity Index, Friedrich’s Dysphonia Index, Global-Roughness-Breathiness scale, Quality of Life, and Peak Inspiratory Flow were evaluated 18 months after EAAL.

Results
All patients had a stable and adequate airway during the follow-up. Ten patients (16.4%) experienced complete bilateral motion recovery with objective acoustic parameters in the physiological ranges. Most functional results of the 13 patients (21.3%) with unilateral recovery also reached the normal values. Fifteen patients (24.6%) had unilateral adduction recovery only, with slightly impaired voice quality. Eleven patients (18.0%) had false vocal fold phonation with socially acceptable voice. In 12 patients (19.7%) no significant motion recovery was detected on the glottic level.

Conclusion
EAAL does not interfere with the potential regeneration process and meets the most important phoniatric requirements while guaranteeing the reversibility of the procedure—therefore serving patients with transient palsy. Further, a socially acceptable voice quality and an adequate airway are ensured even in cases of permanent bilateral vocal fold paralysis.
Integrating trauma, self-disturbances, cognitive biases, and personality into a model for the risk of psychosis: a longitudinal study in a non-clinical sample
Authors: Pionke-Ubych Renata , Frydecka Dorota , Cechnicki Andrzej , Krężołek Martyna , Nelson Barnaby , Gawęda Łukasz 
Published: December 2021

AbstractThe hypothesis of the psychosis continuum enables to study the mechanisms of psychosis risk not only in clinical samples but in non-clinical as well. The aim of this longitudinal study was to investigate self-disturbances (SD), a risk factor that has attracted substantial interest over the last two decades, in combination with trauma, cognitive biases and personality, and to test whether SD are associated with subclinical positive symptoms (PS) over a 12-month follow-up period. Our study was conducted in a non-clinical sample of 139 Polish young adults (81 females, ageM = 25.32, SD = 4.51) who were selected for frequent experience of subclinical PS. Participants completed self-report questionnaires for the evaluation of SD (IPASE), trauma (CECA.Q), cognitive biases (DACOBS) and personality (TCI), and were interviewed for subclinical PS (CAARMS). SD and subclinical PS were re-assessed 12 months after baseline measurement. The hypothesized model for psychosis risk was tested using path analysis. The change in SD and subclinical PS over the 12-month period was investigated with non-parametric equivalent of dependent sample t-tests. The models with self-transcendence (ST) and harm avoidance (HA) as personality variables were found to be well-fitted and explained 34% of the variance in subclinical PS at follow-up. Moreover, we found a significant reduction of SD and subclinical PS after 12 months. Our study suggests that combining trauma, cognitive biases, SD and personality traits such as ST and HA into one model can enhance our understanding of appearance as well as maintenance of subclinical PS.
Targeting abundant survivin expression in liposarcoma: subtype dependent therapy responses to YM155 treatment
Authors: Vay Christian , Schlünder Philipp M. , Dizdar Levent , Esposito Irene , Ghadimi Markus P. H. , Knoefel Wolfram T. , Krieg Andreas 
Published: December 2021

AbstractPurposeLiposarcoma (LPS) represent the largest group of malignant soft tissue tumours comprising a heterogeneous group of subtypes in which the degrees of chemoresistance and radiosensitivity strongly vary. Consequently, it is of utmost interest to establish novel therapeutic regimens based on molecular targets.MethodsImmunohistochemical staining of survivin was performed in tissue microarrays comprising 49 primary LPS specimens. LPS cell lines were treated with survivin antagonist YM155 and doxorubicin or etoposide alone as well as in combination. Changes in cell viability were investigated and the synergistic effect of a combined therapy analysed.ResultsImmunohistochemistry revealed an abundant expression of survivin in LPS that significantly concurred with less-differentiated tumour subtypes and grading. In vitro, we demonstrated the impact of the survivin inhibitor YM155 on dedifferentiated LPS (DDLPS) and, even more imposing, pleomorphic LPS (PLS) tumour cell viability with a strong induction of apoptosis. A combined treatment of doxorubicin or etoposide with YM155 augmented the cytotoxic effects on DDLPS and PLS cells.ConclusionThese findings support the significant role of survivin in the oncogenesis and progression of LPS subtypes providing a rationale to target survivin in eligible in-vivo models and to pioneer clinical applications of survivin-specific substances unfolding their therapeutic potential in LPS patients prospectively.
Fine structure of mushroom bodies and the brain in Sthenelais boa (Phyllodocida, Annelida)
Authors: Beckers Patrick , Pein Carla , Bartolomaeus Thomas 
Published: December 2021

AbstractMushroom bodies are known from annelids and arthropods and were formerly assumed to argue for a close relationship of these two taxa. Since molecular phylogenies univocally show that both taxa belong to two different clades in the bilaterian tree, similarity must either result from convergent evolution or from transformation of an ancestral mushroom body. Any morphological differences in the ultrastructure and composition of mushroom bodies could thus indicate convergent evolution that results from similar functional constraints. We here study the ultrastructure of the mushroom bodies, the glomerular neuropil, glia-cells and the general anatomy of the nervous system in Sthenelais boa. The neuropil of the mushroom bodies is composed of densely packed, small diameter neurites that lack individual or clusterwise glia enwrapping. Neurites of other regions of the brain are much more prominent, are enwrapped by glia-cell processes and thus can be discriminated from the neuropil of the mushroom bodies. The same applies to the respective neuronal somata. The glomerular neuropil of insects and annelids is a region of higher synaptic activity that result in a spheroid appearance of these structures. However, while these structures are sharply delimited from the surrounding neuropil of the brain by glia enwrapping in insects, this is not the case in Sthenelais boa. Although superficially similar, there are anatomical differences in the arrangement of glia-cells in the mushroom bodies and the glomerular neuropil between insects and annelids. Hence, we suppose that the observed differences rather evolved convergently to solve similar functional constrains than by transforming an ancestral mushroom body design.
Basement and cover architecture in the Central Pyrenees constrained by gravity data
Authors: Clariana P. , Soto R. , Ayala C. , Casas-Sainz A. M. , Román-Berdiel T. , Oliva-Urcia B. , Pueyo E. L. , Beamud E. , Rey-Moral C. , Rubio F. , Margalef A. , Schamuells S. , Bach N. , Martí J. 
Published: December 2021

AbstractA new gravity survey (1164 gravity stations and 180 samples for density analysis) combined with two new geological cross sections has been carried out in a sector of the Central Pyrenees in order to improve the characterization of basement and cover architecture. From North to South, the study area comprises the southern half of the Axial Zone and the northernmost part of the South-Pyrenean Zone. New gravity data were combined with previous existing databases to obtain the Bouguer and residual anomaly maps of the study area. The two cross sections, oriented NNE–SSW, were built from field data and previous surficial and subsurface data and cross the La Maladeta plutonic complex. The residual anomaly map shows values ranging from −18 to 16 mGal and anomalies mainly oriented N120E. The two 2.5D modelled cross sections show similar observed gravity curves coinciding with similar interpreted structural architecture. Data show a gravity high oriented N120E coinciding with the Orri basement thrust sheet and an important gravity depression, with the same orientation, coinciding with the leading edge at depth of the Rialp basement thrust sheet and interpreted as linked to a large subsurface accumulation of Triassic evaporites. The volume at depth of the La Maladeta and Arties granites has been constrained through gravity modelling. This work highlights that the combination of structural geology and gravity modelling can help to determine the structural architecture of an orogen and localize accumulations of evaporites at depth.
On the incorporation of strontium into the crystal structure of bredigite: structural effects and phase transition
Authors: Kahlenberg Volker , Prosser Lukas , Salzmann Michael F. , Hejny Clivia 
Published: December 2021

AbstractSr-substitution in the crystal structure of bredigite has been studied in detail. Samples of a hypothetical solid-solution series with nominal composition Ca7-xSrxMg[SiO4]4 (x = 0, 2, …,7) have been prepared from sinter reactions in the temperature range between 1275 and 1325 °C and characterized using powder and single-crystal X-ray diffraction. Synthesis runs between x = 1 and x = 4 resulted in compounds with increasing Sr contents, for which single-crystal diffraction studies revealed the following Sr/(Sr + Ca) atomic ratios: 0.133,0.268, 0.409 and 0.559. They are isostructural to the pure calcium end-member (x = 0) and adopt the orthorhombic space group Pnnm. Evolution of the unit-cell parameters and cell volumes of the solid-solution series are defined by linear or nearly linear trends when plotted against the Sr/(Sr + Ca) atomic ratio. Replacement of calcium with strontium atoms on the different sites shows clear preferences for specific positions. For the experiment with x = 5, formation of bredigite-related single-crystals with Sr/(Sr + Ca) = 0.675 was observed. These samples, however, exhibited a halved c lattice parameter when compared with the corresponding value in the Pnnm structure, pointing to a compositionally induced phase transition somewhere in region between Sr/(Sr + Ca) = 0.559 and 0.675. The crystal structure of this new phase with composition Ca2.32Sr4.82Mg0.86[SiO4]4 was successfully determined in space group Pbam. Basic crystallographic data are as follows: a = 18.869(2) Å, b = 6.9445(8) Å, c = 5.5426(6) Å, V = 726.28(14) Å3, Z = 2. Structure determination was accomplished using charge flipping. Subsequent least-squares refinements resulted in a residual of R(|F|) = 2.70% for 822 independent reflections and 87 parameters. The Pbam- and the Pnnm-structures are in a group-subgroup relationship and topologically related. Both are based on so-called pinwheel-like MSi6O24 clusters consisting of a central magnesium-dominated [MO6]-octahedron as well as six attached [SiO4]-tetrahedra. The clusters are linked into chain-like elements running along [001]. Linkage between the chains is provided by mixed Sr/Ca positions with 6 to 10 oxygen ligands. Differences between the two phases result from changes in Sr-Ca site occupancies in combination with displacements of the atoms and tilts of the tetrahedra. The distortion pattern has been studied using group-theoretical methods including mode analysis. Notably, for the samples with x = 6 and x = 7—the latter corresponding to the hypothetical pure strontium end-member composition—no bredigite-type phases could be identified, indicating that there is an upper limit for the Sr-uptake.
Institutions and institutional changes: aquatic food production in Central Luzon, Philippines
Authors: Manlosa Aisa O. , Hornidge Anna-Katharina , Schlüter Achim 
Published: December 2021

AbstractAquaculture is the most rapidly growing food production sector globally. In certain coastal social-ecological systems, this has resulted in significant changes and sustainability challenges. In particular, coastal environments which used to support only capture fisheries are becoming sites for brackish water aquaculture production; this impacts the sustainability of aquatic food production. Sustainability challenges associated with aquaculture expansion and intensification necessitate a contextually rooted understanding of institutions and institutional changes which can be used as an informed basis for leveraging institutions to achieve desirable sustainability outcomes in the aquatic food sector. This research used a qualitative empirical case study involving in-depth interviews, participant observation, and analysis of institutional documents in the region of Central Luzon, Philippines. It applied the inter-institutional systems concept which considers multiple institutions with distinct but linked purposes and functions in the societal spheres of state, market, and civil society. The study found that aquaculture emerged as an important livelihood because of rice farmers’ need to adapt to saltwater intrusion into what were formerly rice farms. It grew into an industry due to developments in the availability and accessibility of inputs such as fingerlings and feeds. This process was also driven by the high demand and high profitability of fish farming at the time. Regulatory institutions have not adequately adapted to protect the environment. Market institutions adapted but the changes mostly benefited consignacions (middlemen) and large-scale players. However, organised groups of collaborating smallholder fishers and fish farmers are helping to address the disadvantages they face.
Sensitivity analysis for unobserved confounding in causal mediation analysis allowing for effect modification, censoring and truncation
Authors: Lindmark Anita 
Published: December 2021

AbstractCausal mediation analysis is used to decompose the total effect of an exposure on an outcome into an indirect effect, taking the path through an intermediate variable, and a direct effect. To estimate these effects, strong assumptions are made about unconfoundedness of the relationships between the exposure, mediator and outcome. These assumptions are difficult to verify in a given situation and therefore a mediation analysis should be complemented with a sensitivity analysis to assess the possible impact of violations. In this paper we present a method for sensitivity analysis to not only unobserved mediator-outcome confounding, which has largely been the focus of previous literature, but also unobserved confounding involving the exposure. The setting is estimation of natural direct and indirect effects based on parametric regression models. We present results for combinations of binary and continuous mediators and outcomes and extend the sensitivity analysis for mediator-outcome confounding to cases where the continuous outcome variable is censored or truncated. The proposed methods perform well also in the presence of interactions between the exposure, mediator and observed confounders, allowing for modeling flexibility as well as exploration of effect modification. The performance of the method is illustrated through simulations and an empirical example.
Model-driven development of asynchronous message-driven architectures with AsyncAPI
Authors: Gómez Abel , Iglesias-Urkia Markel , Belategi Lorea , Mendialdua Xabier , Cabot Jordi 
Published: December 2021

AbstractIn the Internet-of-Things (IoT) vision, everyday objects evolve into cyber-physical systems. The massive use and deployment of these systems has given place to the Industry 4.0 or Industrial IoT (IIoT). Due to its scalability requirements, IIoT architectures are typically distributed and asynchronous. In this scenario, one of the most widely used paradigms is publish/subscribe, where messages are sent and received based on a set of categories or topics. However, these architectures face interoperability challenges. Consistency in message categories and structure is the key to avoid potential losses of information. Ensuring this consistency requires complex data processing logic both on the publisher and the subscriber sides. In this paper, we present our proposal relying on AsyncAPI to automate the design and implementation of these asynchronous architectures using model-driven techniques for the generation of (part of) message-driven infrastructures. Our proposal offers two different ways of designing the architectures: either graphically, by modeling and annotating the messages that are sent among the different IoT devices, or textually, by implementing an editor compliant with the AsyncAPI specification. We have evaluated our proposal by conducting a set of experiments with 25 subjects with different expertise and background. The experiments show that one-third of the subjects were able to design and implement a working architecture in less than an hour without previous knowledge of our proposal, and an additional one-third estimated that they would only need less than two hours in total.
G protein-coupled receptors that influence lifespan of human and animal models
Authors: Lagunas-Rangel Francisco Alejandro 
Published: December 2021

AbstractHumanity has always sought to live longer and for this, multiple strategies have been tried with varying results. In this sense, G protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while maintaining good health since they have a substantial participation in a wide variety of processes of human pathophysiology and are one of the main therapeutic targets. In this way, we present the analysis of a series of GPCRs whose activity has been shown to affect the lifespan of animal and human models, and in which we put a special interest in describing the molecular mechanisms involved. Our compilation of data revealed that the mechanisms most involved in the role of GPCRs in lifespan are those that mimic dietary restriction, those related to insulin signaling and the AMPK and TOR pathways, and those that alter oxidative homeostasis and severe and/or chronic inflammation. We also discuss the possibility of using agonist or antagonist drugs, depending on the beneficial or harmful effects of each GPCR, in order to prolong people's lifespan and healthspan.