bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐related quality of life with fixed‐duration venetoclax‐obinutuzumab for previously untreated chronic lymphocytic leukemia: Results from the randomized, phase 3 CLL14 trial
Authors: Al‐Sawaf Othman , Gentile Brittany , Devine Jacob , Zhang Can , Sail Kavita , Tandon Maneesh , Fink Anna‐Maria , Kutsch Nadine , Wendtner Clemens‐Martin , Eichhorst Barbara , Hallek Michael , Fischer Kirsten 
Published: June 2021

AbstractChronic lymphocytic leukemia (CLL)‐related symptoms impair the well‐being of patients, making improvement of health‐related quality of life (QoL) a goal of treatment. The CLL14 trial demonstrated higher efficacy of fixed‐duration venetoclax‐obinutuzumab (Ven‐Obi) compared to chlorambucil‐obinutuzumab (Clb‐Obi) in patients with previously untreated CLL. To assess patients' QoL, the following patient‐reported outcomes (PRO) measures were assessed: the M.D. Anderson Symptom Inventory (MDASI) core instrument and CLL module and the EORTC Quality of Life Questionnaire Core 30 (EORTC QLQ‐C30). At treatment start, physical functioning (mean 75.9 [standard deviation (SD) ± 20.1] in the Clb‐Obi arm and 76.9 [±19.4] in the Ven‐Obi arm), role functioning (73.6 [±27.86] and 72.6 [±26.9]) and GHS/QoL (63.6 [±21.0] and 60.3 [±20.5]) were comparable between treatment arms per EORTC QLQ‐C30 scale scores. Baseline levels of physical and role functioning were maintained throughout treatment and follow‐up, with no relevant improvement or deterioration. On average, patients treated with Ven‐Obi showed a meaningful improvement of GHS/QoL during treatment and follow‐up by at least eight points at cycle three, whereas improvement was delayed until cycle eight with Clb‐Obi. According to MDASI scores, CLL symptoms (1.5 [±1.2] and 1.6 [±1.3]), core cancer symptoms (1.5 [±1.4] and 1.8 [±1.7]) and symptom interference (2.1 [±2.3] and 2.3 [±2.3]) were generally low and comparable between treatment arms at baseline and were maintained throughout treatment and follow‐up. This analysis demonstrates that the higher efficacy of Ven‐Obi is not associated with QoL impairment and that Ven‐Obi achieves early relief of CLL‐related symptoms in elderly unfit patients.
Thermal‐Responsive Polyoxometalate–Metalloviologen Hybrid: Reversible Intermolecular Three‐Component Reaction and Temperature‐Regulated Resistive Switching Behaviors
Authors: Huang You‐Ren , Lin Xiang‐Ling , Chen Bin , Zheng Hui‐Dong , Chen Zhi‐Rong , Li Hao‐Hong , Zheng Shou‐Tian 
Published: June 2021

AbstractThe development of new‐type memristors with special performance is of great interest. Herein, an inorganic‐organic hybrid crystalline polyoxometalate (POM) with usual dynamic structures is reported and used as active material for fabricating memristor with unique temperature‐regulated resistive switching behaviors. The hybrid POM not only exhibits tunable thermochromic properties, but also thermal‐induced reversible aggregation and disaggregation reactions, leading to reversible structural transformations in SCSC fashion. Further, the memory device using the hybrid POM as active layer exhibits uncommon performance, which can keep resistive switching silent in the low temperature range of 30–150 °C, but show nonvolatile memory behavior in the high temperature range of 150–270 °C. Particularly, the silent and working states at three special temperatures (30, 150 and 270 °C) can be monitored by chromism. The correlation between structure and resistive switching property of the material has been discussed. The work demonstrates that crystalline inorganic‐organic hybrid POMs are promising materials for making memristors with superior performance.
Decatungstate‐Mediated C(sp3)–H Heteroarylation via Radical‐Polar Crossover in Batch and Flow
Authors: Wan Ting , Capaldo Luca , Laudadio Gabriele , Nyuchev Alexander V. , Rincón Juan A. , García‐Losada Pablo , Mateos Carlos , Frederick Michael O. , Nuño Manuel , Noël Timothy 
Published: June 2021

AbstractPhotocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3)–H functionalization of organic molecules. Herein, we report on the unprecedented combination of decatungstate hydrogen atom transfer photocatalysis with the oxidative radical–polar crossover concept to access the direct net‐oxidative C(sp3)–H heteroarylation. The present methodology demonstrates a high functional group tolerance (40 examples) and is scalable when using continuous‐flow reactor technology. The developed protocol is also amenable to the late‐stage functionalization of biologically relevant molecules such as stanozolol, (−)‐ambroxide, podophyllotoxin, and dideoxyribose.
Zeolitic imidazolate frameworks (ZIF‐8, ZIF‐67, and ZIF‐L) for hydrogen production
Authors: Abdelhamid Hani Nasser 
Published: June 2021

Hydride materials have good performance for hydrogen (H2) gas storage and release. The release of H2 gas from hydrides via the hydrolysis process can be improved or controlled using a catalyst. Herein, benzoic acid (BA) and hexamethylenetetramine (HMTA) modulate the synthesis of hierarchical porous zeolitic imidazolate framework‐8 (HFZIF‐8, Zn‐based metal organic frameworks [MOFs]), ZIF‐67 (Co‐based MOFs), and leaf‐like ZIF (ZIF‐L). The mechanistic study for the synthesis procedure of ZIF‐8 revealed an in situ synthesis of zinc hydroxide nitrate nanosheets (100‐ to 150‐nm thickness) with an interplanar distance of 0.97 nm between the layers of zinc hydroxide, Zn5(OH)82+. X‐ray diffraction (XRD) data indicated that benzoate ions replaced nitrate ions (2NO3−) between Zn5(OH)82+ layers leading to an increase in the interplanar distance (from 0.97 nm to 1.9 nm). Zinc hydroxide benzoate nanosheets showed a fast conversion into HPZIF‐8 at room temperature. The concentration of BA and HMTA tuned the porosity of HPZIF‐8, offering a hierarchical micropore–mesopore structure. The prepared materials increased the hydrolysis rate of sodium borohydride. ZIF‐8 and ZIF‐67 prepared using BA showed high catalytic performance in terms of efficiency and reaction time compared with other materials. The result's findings open new avenues for the synthesis of adequate materials for hydrogen generation via the hydrolysis of hydrides.
Exploring the functional relation of magnetic density and magnetocaloric effect based on a dinuclear system
Authors: Liu Zi‐Yuan , Huang Xu‐Ke , Chen Zi‐Lu , Liu Dong‐Cheng , Zou Hua‐Hong , Liang Fu‐Pei 
Published: June 2021

Molecular magnetic refrigerating material is a kind of green and environmentally friendly materials, which achieve the purpose of cooling by its magnetocaloric effect. Magnetic density is crucial to the magnetocaloric effect of the complexes, and it is usually described by the parameters of Mw/NGd or metal/ligand mass ratio, which represents the content of Gd (III) in the complexes. In order to establish the functional relation between these parameters and magnetocaloric effect, doping is a credible method without changing the coordination environment of the system, which is realized by the process of increasing Gd (III) gradually in the diamagnetic complex. Hence, a diamagnetic dinuclear Y2, four doped samples Gd0.24Y1.76, Gd0.51Y1.49, Gd1.04Y0.96, and Gd1.46Y0.54, and a pure dinuclear Gd2 were synthesized and characterized. Through the measurement of magnetic properties and data fitting, the functional relations were obtained between these parameters and −ΔSm in this dinuclear system. It is the first time that the relationships are set up via experimental design, and it will contribute to observation and comprehension of how magnetic density affects the magnetocaloric effect. In addition, the −ΔSm of dinuclear Gd2 is 29.96 J kg−1 K−1, which is higher than most of the reported dinuclear Gd (III)‐based complexes.
Trophic niche overlap between native freshwater mussels (Order: Unionida) and the invasive Corbicula fluminea
Authors: Modesto Vanessa , Dias Ester , Ilarri Martina , Lopes‐Lima Manuel , Teixeira Amílcar , Varandas Simone , Castro Paulo , Antunes Carlos , Sousa Ronaldo 
Published: June 2021

Abstract

Freshwater mussels (Order Unionida) are highly threatened. Interspecific competition for food sources with invasive alien species is considered to be one of the factors responsible for their decline because successful invaders are expected to have wider trophic niches and more flexible feeding strategies than their native counterparts.
In this study, carbon (δ13C: 13C/12C) and nitrogen (δ15N: 15N/14N) stable isotopes were used to investigate the trophic niche overlap between the native freshwater mussel species, Anodonta anatina, Potomida littoralis, and Unio delphinus, and the invasive bivalve Corbicula fluminea living in sympatry in the Tua basin (south‐west Europe).
The species presenting the widest trophic niches were C. fluminea and A. anatina, which indicate that they have broader diets than U. delphinus and P. littoralis. Nonetheless, all the species assimilated microphytobenthos, sediment organic matter, and detritus derived from vascular plants, although with interspecific variability in the assimilated proportions of each source. The trophic niche of the invasive species overlapped with the trophic niche of all the native species, with the extent varying between sites and according to the species.
From the three native species analysed, Potomida littoralis may be at a higher risk for competition for food with C. fluminea in the Tua basin, if food sources become limited, because this native mussel presented the narrowest trophic niche across sites and the highest probability of overlapping with the trophic niche of C. fluminea.
Given the global widespread distribution of C. fluminea, the implementation of management measures devoted to the control or even eradication of this invasive alien species should be a conservation priority given its potential for competition with highly threatened native freshwater mussels.
Identifying marsupials from Australian archaeological sites: current methodological challenges and opportunities in zooarchaeological practice
Authors: MEIN ERIN , MANNE TIINA 
Published: June 2021

AbstractWe review current zooarchaeological practice in Australia, identifying major research themes and key methodological gaps where opportunities exist for the development of Australian zooarchaeology as a discipline. We demonstrate that marsupial remains form a significant component of Australian zooarchaeological assemblages, yet high resolution taxonomic identification of these remains continues to prove challenging, owing to a combination of high species diversity and few resources which provide diagnostic criteria for discriminating morphologically similar, but ecologically variable taxa. The lack of robust protocols for discriminating marsupial taxa significantly impacts our ability to effectively integrate zooarchaeological data into broader narratives of Aboriginal colonisation, resilience and adaptation across Australia. Publication of identification protocols would help refine and standardise diagnostic criteria used between analysts, improve the methodological transparency of zooarchaeological analysis and provide resources for the training of a new generation of specialists. A range of opportunities currently exist, utilising qualitative and quantitative techniques, to significantly contribute towards the methodological robustness of zooarchaeological practice in Australia.
Suppression of the TRIF‐dependent signaling pathway of TLRs by epoxomicin
Authors: Kim Su Y. , Shin Seokwon , Kwon Minji , Youn Daniel , Sung Nam J. , Kim Na H. , Park Sin‐Aye , Youn Hyung‐Sun 
Published: June 2021

AbstractToll‐like receptors (TLRs) can recognize specific signatures of invading microbial pathogens and activate a cascade of downstream signals to induce the secretion of inflammatory cytokines, chemokines, and type I interferons. The activation of TLRs triggers two downstream signaling pathways: the MyD88‐ and the TRIF‐dependent pathways. To evaluate the therapeutic potential of epoxomicin, a member of the linear peptide αʹ,βʹ‐epoxyketone first isolated from an actinomycetes strain, we examined its effects on signal transduction via TLR signaling pathways. Epoxomicin inhibited the activation of NF‐kB and IRF3 induced by TLR agonists, decreased the expression of interferon‐inducible protein‐10, and inhibited the activation of NF‐kB and IRF3 induced by overexpression of downstream signaling components of TLR signaling pathways. These results suggest that epoxomicin can regulate both the MyD88‐ and TRIF‐dependent signaling pathways of TLRs. Thus, it might have potential as a new therapeutic drug for a variety of inflammatory diseases.
Tenascin‐C regulates migration of SOX10 tendon stem cells via integrin‐α9 for promoting patellar tendon remodeling
Authors: Xu Kang , Shao Yibo , Xia Yi , Qian Yuna , Jiang Nan , Liu Xianqiong , Yang Li , Wang Chunli 
Published: June 2021

AbstractInsufficient attention has been focused on the directional migration of SOX10+ tendon stem cells (STSCs) during tendon remodeling. Here, we investigate whether tenascin‐C (TNC) promotes STSC motility and migration. Based on the hypothesis that TNCs induce STSC migration, RNA‐sequencing (RNA‐seq) was conducted, identifying 2107 differentially expressed genes (DEGs), of which 1272 were up‐regulated and 835 down‐regulated following treatment with TNC versus the control. The DEGs were principally involved in cell adhesion and cell membrane signal transduction. Highly enriched‐related signaling included the PI3K‐Akt, focal adhesion, and ECM–receptor interaction pathways. Protein interaction analysis established that TNC was positively correlated with ITGA9 (integrin‐α9). Furthermore, TNC activated the phosphorylation levels of FAK and Akt, and knockdown of ITGA9 with siRNA revealed that TNC contributes to STSC migration via the targeting of ITGA9. In addition, in vivo administration of TNC promoted tissue regeneration of injured tendons. In conclusion, TNC regulated the migration of STSCs via ITGA9, thereby promoting the regeneration of tendon injuries.
Adoption of single agent anticancer therapy for advanced hepatocellular carcinoma and impact of facility type, insurance status, and income on survival: Analysis of the national cancer database 2004–2014
Authors: Opneja Aman , Cioffi Gino , Alahmadi Asrar , Jones Nelroy , Tang Tin‐Yun , Patil Nirav , Bajor David L. , Saltzman Joel N. , Mohamed Amr , Selfridge Eva , Mangla Ankit , Barnholtz‐Sloan Jill , Lee Richard T. 
Published: June 2021

AbstractBackgroundThis study analyzes the pattern of use of single agent anticancer therapy (SAACT) in the treatment and survival of advanced hepatocellular carcinoma (aHCC) before and after sorafenib was FDA approved in 2007.MethodsAdult patients diagnosed with HCC and treated with only ACT from 2004 – 2014 were identified in NCDB database. Patients were analyzed during three time frames: 2004–2006 (pre‐sorafenib (PS)), 2007–2010 (early sorafenib (ES)) and 2011–2014 (late sorafenib (LS)). Cox proportional hazards models and Kaplan‐Meier method were used for analyses.ResultsThe NCDB contained 31,107 patients with HCC diagnosed from 2004–2014 and treated with ACT alone. Patients were generally men (78.0%), >50 years of age (92.5%). A significant increase in the rate of adaption of SAACT was observed over time: 6.2% PS, 15.2% ES, and 22.2% LS (p < 0.0001). During this later period, the highest proportion of SAACT is among academic and integrated network facilities (23.3%) as compared to community facilities (17.0%, p < 0.0001). The median overall survival of patients with aHCC treated only with SAACT improved significantly over time from 8.0 months (m) (95% CI: 7.4–8.8) to 10.7 m (10.4–11.2) to 15.6 m (15.2–16.0, p < 0.001). Multivariate analysis indicates worse outcomes for patients treated at community cancer programs (HR 1.28, (5% CI: 1.23–1.32), patients without insurance (HR 1.11, 1.06–1.16) and estimated household income of <$63,000 (HR 1.09, 1.05–1.13).ConclusionaHCC patients treated only with ACT have experienced an overall improvement in survival, but significant differences exist between facility type, insurance status, and income.
Protein Macrocyclization for Tertiary Structure Stabilization
Authors: Haim Anissa , Neubacher Saskia , Grossmann Tom N. 
Published: June 2021

AbstractProteins possess unique molecular recognition capabilities and enzymatic activities, features that are usually tied to a particular tertiary structure. To make use of proteins for biotechnological and biomedical purposes, it is often required to enforce their tertiary structure in order to ensure sufficient stability under the conditions inherent to the application of interest. The introduction of intramolecular crosslinks has proven efficient in stabilizing native protein folds. Herein, we give an overview of methods that allow the macrocyclization of expressed proteins, discussing involved reaction mechanisms and structural implications.
In Situ Synchrotron X‐ray Diffraction Studies of the Mechanochemical Synthesis of ZnS from its Elements
Authors: Petersen Hilke , Reichle Steffen , Leiting Sebastian , Losch Pit , Kersten Wolfgang , Rathmann Tobias , Tseng Jochi , Etter Martin , Schmidt Wolfgang , Weidenthaler Claudia 
Published: June 2021

AbstractMechanochemistry, as a synthesis tool for inorganic materials, became an ever‐growing field in material chemistry. The direct energy transfer by collision of the educts with the milling media gives the possibility to design environmental‐friendly reactions. Nevertheless, the underlying process of energy transfer and hence the kinetics of mechanosynthesis remain unclear. Herein, we present in situ synchrotron X‐ray diffraction studies coupled with pressure measurements performed during the formation of ZnS and the subsequent phase transition (PT) from the hexagonal to the cubic modification. Milling Zn and S8 results in the sublimation of S8, observed by a sudden pressure increase. Simultaneously, the hexagonal metastable ZnS‐modification (wurtzite) forms. Via detection of the pressure maximum, the exact start of the wurtzite formation can be determined. Immediately after the formation of wurtzite, the structural PT to the thermodynamic stable cubic modification sphalerite takes place. This PT can be described by the Prout‐Tompkins equation for autocatalytic reactions, similar to thermally induced PT in sulfur vapor at high temperatures (T>1133 K). The increase in the reactivity of the wurtzite formation is explained by the reaction in sulfur vapor and the induction of defect structures by the collisions with the milling media.
Tris(pentafluoroethyl)silanol Derivatives and the Lewis Amphoteric Tris(pentafluoroethyl)silanolate Anion, [Si(C2F5)3O]−
Authors: Tiessen Natalia , Schwarze Nico , Keßler Mira , Neumann Beate , Stammler Hans‐Georg , Hoge Berthold 
Published: June 2021

AbstractWhile alkyl‐substituted siloxanes are widely known, virtually nothing is known about perfluoroalkyl siloxanes and their congener species, the silanols and silanolates. We recently reported on the tris(pentafluoroethyl)silanide ion, [Si(C2F5)3]−, which features Lewis amphoteric character deriving from the pentafluoroethyl substituents and their strong electron‐withdrawing properties. Transferring this knowledge, we investigated the Lewis amphoteric behavior of the tris(pentafluoroethyl)silanolate, [Si(C2F5)3O]−. In order to examine such Lewis amphoteric behavior, we first developed a strategy for the synthesis of the corresponding silanol Si(C2F5)3OH, which readily condenses at room temperature to the hexakis(pentafluoroethyl)disiloxane, (C2F5)3SiOSi(C2F5)3. Deprotonation of Si(C2F5)3OH employing a sterically demanding phosphazene base allows the characterization of the first example of a dimeric triorganosilanolate: the dianionic hexakis(pentafluoroethyl)disilanolate, [{Si(C2F5)3O}2]2−, implies Lewis amphoteric character of the monomeric [Si(C2F5)3O]− anion.
Sauber in Richtung Zukunft
Authors: Bolz Lukas 
Published: June 2021

AbstractWasserstoff ist ein zentrales Element für die klimaneutrale Zukunft. Die Firma Proton Motor Fuel Cell setzt JUMO VIBROtemp Temperatursensoren zur Temperaturüberwachung in Brennstoffzellen‐Systemen ein.
Automatikmodul für Rotationsverdampfer
Authors: Heyder Jürgen 
Published: June 2021

AbstractDie autarke Lösung aus Rotationsverdampfer und Hei‐Volume Distimatic Pro Modul kann unbeaufsichtigt Tag und Nacht betrieben werden. Dank der automatischen Rückstandsentleerung entfällt eine manuelle Entnahme während des Prozesszyklus. Dadurch besteht die
Experimental Considerations for Operando Metal‐Ion Battery Monitoring using X‐ray Techniques
Authors: Saurel D. , Pendashteh A. , Jáuregui M. , Reynaud M. , Fehse M. , Galceran M. , Casas‐Cabanas M. 
Published: June 2021

AbstractInvited for this month's cover is the group of Damien Saurel and Montserrat Canas‐Cabanas at CIC EnergiGUNE and Ikerbasque (Spain). the data corresponding to NaTiOPO4 Na‐ion anode material obtained in a powder X‐ray diffraction operando experiment when cycled between 2.4 and 1V vs Na+/Na (2θ λ Cu = 32° ‐ 34 °, reversible intercalation of 0.58 Na+). Operando experiments have provided key insights regarding the internal processes occurring in a battery during operation and this knowledge has been critical for the design of optimized electrode materials and long‐lasting cells. In our work we discuss several experimental considerations that we believe are relevant for operando data acquisition and analysis through different examples collected using our home‐made in situ cell using both lab‐scale and synchrotron data. Read the full text of their Full Paper at 10.1002/cmtd.202100009.
Securing continuation of treatment for children with cancer in times of social unrest and pandemic
Authors: Zuleta Verónica , Berliner Josefina , Rossell Nuria , Zubieta Marcela 
Published: June 2021

AbstractBackgroundChildhood cancer in Chile reports 500 new cases each year of which 85% are treated in the public health system. Governmental programs ensure access to diagnosis, treatment, follow up and palliative care, whereas Fundación Nuestros Hijos (FNH) provides supportive care for non‐covered medical and psychosocial needs. Common financial difficulties in families of children and adolescents with cancer increased considerably when a wave of social unrest arose in October 2019 and the Covid‐19 pandemic in March 2020 hit the country, leaving families of children with cancer facing greater challenges.AimsWe report here the support activities and interventions carried out by FNH to help the families during the crisis of these months.MethodsA socioeconomic survey was conducted among FNH's beneficiary families to know their needs. During these months of acute crisis for many families, support activities and interventions were developed and varied types of aid were allocated to help the families.ResultsThe main results of the survey in which 525 (70%) of FNH's beneficiary families participated showed that 75% of them had only one breadwinner, and 52% had one unemployed family member. Almost 90% of job loss happened during the months of social unrest and pandemic. Four main interventions: (a) safe transportation, (b) food, (c) heating, (d) internet connectivity, were organized to support important needs of the families and prevent children to miss treatment appointments. Additionally, some families who did not access governmental emergency aid were guided in the process.ConclusionsThe aid provided helped the families to relieve some of their needs, facilitated the continuation of treatment during the pandemic, and made the caregivers feel supported and listened.