bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapie eines bullösen Pemphigoids bei einem Warmblutwallach
Authors: Ehrmann Carolin , Hartung Svenja , Hirz Manuela , Fey Kerstin 
Published: October 2021

ZusammenfassungEin 15-jähriger Warmblutwallach wurde wegen multipler großflächiger, ulzerativer und krustiger Hautveränderungen vorgestellt, die seit 4 Jahren bestanden. Anhand der histologischen Untersuchung von Hautbioptaten wurde eine subepidermale Spaltbildung unterhalb der Basalzellen und oberhalb der Basalmembran festgestellt und ein bullöses Pemphigoid diagnostiziert. Durch eine immunsuppressive Therapie mit Dexamethason und Azathioprin konnte nach 14 Wochen eine vollständige Remission der Hautläsionen erreicht werden, wobei die betroffenen Hautareale durch Narbengewebe ersetzt wurden. Die Dauertherapie wurde nach schrittweiser Dosisreduktion über 5 Monate mit einer Erhaltungsdosis von 0,5 mg/kg Azathioprin täglich fortgesetzt. Nach 63 Wochen erfolgreicher Stabilisierung kam es zu einem Rezidiv sowie zusätzlich zu unerwünschten Arzneimittelnebenwirkungen (akute Hufrehe und erhöhte Infektanfälligkeit), sodass der Wallach aus Tierschutzgründen euthanasiert wurde.
Osteochondral Allograft Reconstruction of the Tibia Plateau for Posttraumatic Defects—A Novel Computer-Assisted Method Using 3D Preoperative Planning and Patient-Specific Instrumentation
Authors: Zaleski Martin , Hodel Sandro , Fürnstahl Philipp , Vlachopoulos Lazaros , Fucentese Sandro F. 
Published: October 2021

Abstract
Background Surgical treatment of posttraumatic defects of the knee joint is challenging. Osteochondral allograft reconstruction (OCAR) is an accepted procedure to restore the joint congruity and for pain relief, particularly in the younger population. Preoperative three-dimensional (3D) planning and patient-specific instrumentation (PSI) are well accepted for the treatment of posttraumatic deformities for several pathologies. The aim of this case report was to provide a guideline and detailed description of the preoperative 3D planning and the intraoperative navigation using PSI in OCAR for posttraumatic defects of the tibia plateau. We present the clinical radiographic results of a patient who was operated with this new technique with a 3.5-year follow-up.
Materials and Methods 3D-triangular surface models are created based on preoperative computer tomography (CT) of the injured side and the contralateral side. We describe the preoperative 3D-analysis and planning for the reconstruction with an osteochondral allograft (OCA) of the tibia plateau. We describe the PSI as well as cutting and reduction techniques to show the intraoperative possibilities in posttraumatic knee reconstructions with OCA.
Results Our clinical results indicate that 3D-assisted osteotomy and OCAR for posttraumatic defects of the knee may be beneficial and feasible. We illustrate the planning and execution of the osteotomy for the tibia and the allograft using PSI, allowing an accurate anatomical restoration of the joint congruency.
Discussion With 3D-planning and PSI the OCAR might be more precise compared with conventional methods. It could improve the reproducibility and might allow less experienced surgeons to perform the precise and technically challenging osteotomy cuts of the tibia and the allograft. Further, this technique might shorten operating time because time consuming intraoperative steps such as defining the osteotomy cuts of the tibia and the allograft during surgery are not necessary.
Conclusion OCAR of the tibia plateau for posttraumatic defects with 3D preoperative planning and PSI might allow for the accurate restoration of anatomical joint congruency, improve the reproducibility of surgical technique, and shorten the surgery time.
Dispositives of newness and change: academic organisations’ discursive practice at the intersection of excellence and gender
Authors: Wieners Sarah , Maria Weber Susanne 
Published: October 2021

AbstractOn the basis of a genealogical discourse analysis, Weber distinguishes four dispositives of creation. The ‘new’ is created and organised within systematic rationalities of creation. It emerges in (a) an organic cyclical transcendence, (b) a top-down pattern, (c) an entrepreneurial mode that designates man as creator and (d) a collective cyclical dynamic. The dispositives of man as creator and creation as an act are becoming particularly dominant in today’s academic organisations and these dispositives systematically produce institutional programmatics and organisational strategies. In this paper, we analyse how the new emerges in two academic organisations. The starting points of our analyses are two institutional innovations that emerged in Germany in the 2000s: the Excellence Initiative and the gender equality programme. Although they derive from different fields of discourse, both innovations share common features. The Excellence Initiative required universities to relate discourses of excellence and gender equality to each other, and this article investigates how the new emerges in academic organisations to understand whether these innovations produce equality or perpetuate traditional inequalities. Based on Foucault’s dispositive methodology, we use website analyses and interviews with gender equality officers and heads of early-career researchers’ departments. We highlight the discursive connections between gender and excellence for early-career researchers and outline various discursive organisational strategies.
Flavor-dependent photoproduction in heavy-ion collisions
Authors: Xie Zhuoxuan , Han Ruilin 
Published: October 2021

Abstract
Strong electromagnetic fields produced in the non-central heavy-ion collisions can induce vector meson photoproduction. In this paper, we study the photoproduction J/ψ and ϕ mesons in the relativistic heavy-ion collision from ultra-peripheral nuclear collisions to peripheral hadronic heavy ion collisions. And then include both initial hadronic production and thermal production in quark-gluon plasma (QGP). We find, for the charm anti-charm bound state J/ψ, the photoproduced J/ψs are mainly in the very low momentum region and clearly exceed the hadronic production. However, considering the thermal production of strange quark anti-quark pairs in QGP produced in relativistic heavy-ion collisions, the photoproduced ϕ is usually smaller than the thermal production and only evident at very peripheral collisions as even their photoproduction is much larger than J/ψ.
Molecular Clump Extraction Algorithm Based on Local Density Clustering*
Authors: Luo Xiaoyu , Zheng Sheng , Huang Yao , Zeng Shuguang , Zeng Xiangyun , Jiang Zhibo , Chen Zhiwei 
Published: October 2021

Abstract
The detection and parameterization of molecular clumps are the first step in studying them. We propose a method based on the Local Density Clustering algorithm while physical parameters of those clumps are measured using the Multiple Gaussian Model algorithm. One advantage of applying the Local Density Clustering to the clump detection and segmentation, is the high accuracy under different signal-to-noise levels. The Multiple Gaussian Model is able to deal with overlapping clumps whose parameters can reliably be derived. Using simulation and synthetic data, we have verified that the proposed algorithm could accurately characterize the morphology and flux of molecular clumps. The total flux recovery rate in 13CO (J = 1−0) line of M16 is measured as 90.2%. The detection rate and the completeness limit are 81.7% and 20 K km s−1 in 13CO (J = 1−0) line of M16, respectively.
GGCHEMPY: A Pure Python-based Gas-grain Chemical Code for Efficient Simulation of Interstellar Chemistry*
Authors: Ge Jixing 
Published: October 2021

Abstract
In this paper, we present a new gas-grain chemical code for interstellar clouds written in pure Python (GGCHEMPY (GGCHEMPY is available on https://github.com/JixingGE/GGCHEMPY)). By combining with the high-performance Python compiler Numba, GGCHEMPY is as efficient as the Fortran-based version. With the Python features, flexible computational workflows and extensions become possible. As a showcase, GGCHEMPY is applied to study the general effects of three-dimensional projection on molecular distributions using a two-core system which can be easily extended for more complex cases. By comparing the molecular distribution differences between two overlapping cores and two merging cores, we summarized the typical chemical differences such as N2H+, HC3N, C2S, H2CO,

HCN

and C2H, which can be used to interpret 3D structures in molecular clouds.
Spring fires in Russia: results from participatory burned area mapping with Sentinel-2 imagery
Authors: Glushkov Igor , Zhuravleva Ilona , McCarty Jessica L , Komarova Anna , Drozdovsky Alexey , Drozdovskaya Marina , Lupachik Vilen , Yaroshenko Alexey , Stehman Stephen V , Prishchepov Alexander V 
Published: October 2021

Abstract
Human-induced fires play a crucial role in transforming landscapes and contributing to greenhouse gas emissions. Russia is a country where human-induced fires are widespread and form distinctive spring and summer burning cycles. However, spring fires are not well documented and it is unclear which land-cover types are associated with the spread of spring fires. Using Sentinel-2 optical satellite imagery, a wall-to-wall spring burned area data set for 1 January to 15 May 2020 was created for Russia (excluding the Arctic) using a participatory crowdsourcing digitizing approach on an online platform developed specifically for this application. The 2020 spring fire product had a producer accuracy of 85% and user accuracy of 92%. Approximately 13.38 million ha, comprising 1.8% of the study area, were mapped as burned, with the majority of the 2020 spring burned areas in Siberia. Our spring-fire product revealed five times more burned area estimates compared to the burned area estimates from the moderate resolution imaging spectroradiometer (MODIS) MCD64 product. We also found high variability of burned area per active fire pixel across regions of Russia, when compared to MODIS and visible infrared imaging radiometer suite active fire data. Spring fires started to increase from the end of February and reached their maximum by the end of March through the middle of April. Spring fires were associated with arable lands and grasslands as land-cover types, except Siberia, where spring fires were most common in deciduous and needle-leaved forests, followed by arable lands. While spring fires were associated with croplands and grasslands, an estimate for Central Russia showed approximately 75% of spring fires occurred on abandoned agricultural lands. Our study demonstrated the suitability of optical Sentinel-2 imagery for spring fire mapping and the great utility of a participatory mapping approach for fast and accurate mapping as well as engagement of the community.
Future evolution of virtual water trading in the United States electricity sector
Authors: Graham Neal T , Iyer Gokul , Wise Marshall , Hejazi Mohamad , Wild Thomas B 
Published: October 2021

Abstract
Future transformations in the electricity sector could entail major shifts in power sector technology mixes and electricity trade, with consequences for the trading of virtual water. Previous virtual water trade studies largely focus on historical timeframes. We explore, for the first time, future—through 2050—virtual water trade driven by electricity trade under a range of future electricity sector transformation scenarios using the United States as an example. Under a business-as-usual scenario, virtual water trading in 2050 decreases by 3% relative to 2015 levels. By contrast, virtual water trading increases respectively by 3%, 26%, and 32%, in scenarios characterized by higher socioeconomic growth, higher potential for transmission expansion, and low-carbon transitions. These increases are driven by electricity generation expansion in the western U.S., resulting in higher virtual water trade to the east. In addition, we find that as electricity generation shifts west, an increased amount of nonrenewable groundwater will be consumed to generate electricity that is supplied to the east. Independent of scenario, the US electricity grid largely relies on virtual water exports from only a few states. Our study highlights the need for integrated and national strategies to manage the water and electric systems.
Non-negative matrix factorization for 2D-XAS images of lithium ion batteries
Authors: Tanimoto Hiroki , Hongkun Xu , Mizumaki Masaishiro , Seno Yoshiki , Uchiwada Jumpei , Yamagami Ryo , Kumazoe Hiroyuki , Iwamitsu Kazunori , Kimura Yuta , Amezawa Koji , Akai Ichiro , Aonishi Toru 
Published: October 2021

Abstract
Lithium-ion secondary batteries have been used in a wide variety of purposes, such as for powering mobile devices and electric vehicles, but their performance should be improved. One of the factors that limits their performance is the non-uniformity of the chemical reaction in the process of charging and discharging. Many attempts have been made to elucidate the mechanism behind this reaction non-uniformity. In this paper, to detect non-uniformity in various physical properties from Co K-edge two-dimensional x-ray absorption spectroscopy (2D-XAS) images of lithium ion batteries, we propose a method that consists of one-sided orthogonal non-negative matrix factorization in combination with removal of the reference signal. The difference between x-ray absorption spectra acquired at different positions in the battery is very small. However, even in such a situation, our method can decompose the 2D-XAS data into different spatial domains and their corresponding absorption spectra. From the spectral decomposition of the obtained absorption spectra, we confirmed a transition-energy shift of the main peak as evidence for a change in the state of charge and also found spectral changes due to orbital hybridization in the decomposed spectral components.
Possible dispersal of the coastal and subterranean carabid beetle Thalassoduvalius masidai (Coleoptera) by ocean currents
Authors: Nakahama Naoyuki , Okano Ryosuke , Nishimoto Yuichiro , Matsuo Ayumi , Ito Noboru , Suyama Yoshihisa 
Published: October 2021

Abstract
The spatial genetic structures of insects are reflected in their habitats. Coastal insects tend to have less genetic differentiation than subterranean insects. However, the general pattern of population structure of coastal species residing in subterranean habitats is unknown. Thalassoduvalius masidai (Coleoptera: Carabidae: Trechinae), endemic to Japan, is a coastal and subterranean beetle. Here, we hypothesized that T. masidai populations disperse among regions by ocean currents, floods and tsunamis, despite their habitat being underground. To test this hypothesis, we performed a phylogeographical analysis of T. masidai using single nucleotide polymorphism data from multiplexed inter-simple sequence repeat genotyping by sequencing (MIG-seq) and the mitochondrial COI gene. The phylogenetic network and tree and STRUCTURE analyses indicated that T. masidai populations were divided into three groups: the western Seto Inland Sea–Izu Peninsula coasts, the eastern Seto Inland Sea–Kii Peninsula coasts and the Japan Sea coasts. The genetic diversity of T. masidai was higher in sites with lower longitude and latitude. These results suggest that T. masidai migrated and dispersed from the south-western area of Japan by ocean currents, despite its underground habitat. The genetic analysis data from the present study would also be helpful for the conservation and taxonomic revision of this species.
The Importance of Forests in Bumble Bee Biology and Conservation
Authors: Mola John M , Hemberger Jeremy , Kochanski Jade , Richardson Leif L , Pearse Ian S 
Published: October 2021

AbstractDeclines of many bumble bee species have raised concerns because of their importance as pollinators and potential harbingers of declines among other insect taxa. At present, bumble bee conservation is predominantly focused on midsummer flower restoration in open habitats. However, a growing body of evidence suggests that forests may play an important role in bumble bee life history. Compared with open habitats, forests and woody edges provide food resources during phenologically distinct periods, are often preferred nesting and overwintering habitats, and can offer favorable abiotic conditions in a changing climate. Future research efforts are needed in order to anticipate how ongoing changes in forests, such as overbrowsing by deer, plant invasions, and shifting canopy demographics, affect the suitability of these habitats for bumble bees. Forested habitats are increasingly appreciated in the life cycles of many bumble bees, and they deserve greater attention from those who wish to understand bumble bee populations and aid in their conservation.
Daily, monthly and annual thermal performance of a linear Fresnel reflector to drive an organic Rankine-cycle system
Authors: Mahmood Hassan , Hossin Khaled 
Published: October 2021

AbstractThe organic Rankine cycle (ORC) coupled with a linear Fresnel reflector (LFR) utilizes a low-grade heat source. This article presents the study of a small-scale LFR–ORC power-generation plant under the climatic conditions of Almatret, Spain. The mathematical modelling is performed using thermodynamic equations and simulations are conducted to evaluate the optical performance of the LFR system and thermal performance of the ORC plant. Therminol-62 is used as a heat-transfer fluid (HTF) in the solar field, whereas NOVECTM 649 is used as the working fluid in the ORC power system. The LFR is integrated with a thermal-storage unit based on a two-tank system and stores the solar thermal energy via a heat exchanger. The thermal-energy output of the receiver tube of the LFR system is 108 kW and thermal losses are 7.872 kW during the peak time operation of a day at 1:00 p.m. The mechanical power output of the ORC turbine is 7.296 kW using the specific design conditions and the two-tank thermal-storage system adds 4 operation hours to the power plant after sunset.
A Unified Framework to Discover Permutation Generation Algorithms
Authors: Ganapathi Pramod , Chowdhury Rezaul 
Published: October 2021

AbstractWe present two simple, intuitive and general algorithmic frameworks that can be used to design a wide variety of permutation generation algorithms. The frameworks can be used to produce 19 existing permutation algorithms, including the well-known algorithms of Heap, Wells, Langdon, Zaks, Tompkins and Lipski. We use the frameworks to design two new sorting-based permutation generation algorithms, one of which is optimal.
Khorana score at an initial chemotherapy is effective on predicting death in patients with gastrointestinal cancer
Authors: Shibata K , Tokushige A , Imamura M , Ohishi M 
Published: October 2021

Abstract

Background
The Khorana risk score (KRS) has been recommended for predicting an incidence of cancer-associated thrombosis (CAT). On the other hand, KRS is that the specific gravity of score for the primary tumor is too high and the prevalence of severe obesity is low, so there are some reports that the KRS is not effective in predicting CAT but is effective in predicting death.

Purpose
The purpose of this retrospective cohort study was to evaluate the efficacy of KRS on predicting CAT and all-cause death at an initial chemotherapy in patients with gastrointestinal cancer.

Methods
260 consecutive patients with no history of thrombosis who started an initial chemotherapy for gastrointestinal cancer during a 2-year period from January 2017 to December 2018 in our hospital were divided into 3 groups according to KRS and observed until December 2019 (122 patients (46.9%) in the low-risk group (0 points), 114 patients (43.8%) in the intermediate-risk group (1–2 points), and 24 patients (9.2%) in the high-risk group (3–6 points)). The incidence of CAT and all-cause death was compared among 3 groups.

Results
The median age of the patients was 67 (60–75) years, and 63.5% of them were male. CAT was observed in 61 patients (23.5%), and 84 patients (32.3%) died during the observation period. There was no difference in the incidence rate of CAT among 3 groups (Log-rank P=0.6), but all-cause death was a significant difference among 3 groups (high risk group: 54.2%, intermediate risk group: 36.0%, low risk group: 24.6%, p value=0.0023). After adjustment for multivariate analysis, the KRS high risk group was still significantly associated with death (HR: 2.83, 95% CI: 1.37–5.83, p value =0.0049), but not with CAT.

Conclusion
The Khorana score at an initial of chemotherapy in patients with gastrointestinal cancer is useful in predicting prognosis, but not CAT.

Funding Acknowledgement
Type of funding sources: None.
Role of platelet GARP in TGFB activation
Authors: Bodart J , Dufeys C , Senis Y A , Nagy Z , Bertrand L , Beauloye C , Lucas S , Horman S 
Published: October 2021

Abstract

Introduction
Transforming growth factor (TGF)β is known to be a central player in the control of cardiac fibroblast properties and fibrosis. However, cellular and molecular mechanisms that trigger its activation remain poorly understood. Platelets are considered as a major source of TGFβ and recent evidence suggest that they are involved in TGFβ activation via Glycoprotein A Repetitions Predominant (GARP) present on their surface.

Purpose
The present study sought to evaluate the role of platelet GARP in TGFβ activation using platelet specific GARP knockout mice.

Methods
We generated a new Cre transgenic mouse strain that allowed Megakaryocyte/platelet specific invalidation of GARP (GpIba-Cre x GARPfl/fl). The impact of GARP deficiency on platelet function was measured in vitro by flow cytometry using thrombin and CRP. Serum production of total and active TGFβ was assessed by ELISA.

Results
Platelet count and other hematological parameters were normal in platelet specific GARP knockout mice, except platelet volume, which was increased by 10.3%, as compared to wild-type platelets. Stimulation by thrombin and CRP increased GARP exposure at platelet surface. However, platelets without GARP displayed normal agonist induced activation, as reflected by CD62P and αIIbβ3 exposure. Interestingly, the generation of active TGFβ was drastically impaired in the serum of platelet specific GARP knockout mice, while the amount of total TGFβ was not affected.

Conclusion
We provided evidence that platelet GARP is a crucial contributor to the systemic activation of TGFβ. Future work will aim to determine its role in cardiac fibroblast myodifferentiation and fibrosis.

Funding Acknowledgement
Type of funding sources: Other. Main funding source(s): FRIA
Highly Parallel Genomic Selection Response in ReplicatedDrosophila melanogasterPopulations with Reduced Genetic Variation
Authors: Burny Claire , Nolte Viola , Dolezal Marlies , Schlötterer Christian 
Published: October 2021

AbstractMany adaptive traits are polygenic and frequently more loci contributing to the phenotype are segregating than needed to express the phenotypic optimum. Experimental evolution with replicated populations adapting to a new controlled environment provides a powerful approach to study polygenic adaptation. Because genetic redundancy often results in nonparallel selection responses among replicates, we propose a modified evolve and resequence (E&R) design that maximizes the similarity among replicates. Rather than starting from many founders, we only use two inbred Drosophila melanogaster strains and expose them to a very extreme, hot temperature environment (29 °C). After 20 generations, we detect many genomic regions with a strong, highly parallel selection response in 10 evolved replicates. The X chromosome has a more pronounced selection response than the autosomes, which may be attributed to dominance effects. Furthermore, we find that the median selection coefficient for all chromosomes is higher in our two-genotype experiment than in classic E&R studies. Because two random genomes harbor sufficient variation for adaptive responses, we propose that this approach is particularly well-suited for the analysis of polygenic adaptation.