bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of a new symptom checker in patient triage: Canadian cohort study
Authors: Chan Forson , Lai Simon , Pieterman Marcus , Richardson Lisa , Singh Amanda , Peters Jocelynn , Toy Alex , Piccininni Caroline , Rouault Taiysa , Wong Kristie , Quong James K. , Wakabayashi Adrienne T. , Pawelec-Brzychczy Anna 
Published: December 2021

Background
Computerized algorithms known as symptom checkers aim to help patients decide what to do should they have a new medical concern. However, despite widespread implementation, most studies on symptom checkers have involved simulated patients. Only limited evidence currently exists about symptom checker safety or accuracy when used by real patients. We developed a new prototype symptom checker and assessed its safety and accuracy in a prospective cohort of patients presenting to primary care and emergency departments with new medical concerns.

Method
A prospective cohort study was done to assess the prototype’s performance. The cohort consisted of adult patients (≥16 years old) who presented to hospital emergency departments and family physician clinics. Primary outcomes were safety and accuracy of triage recommendations to seek hospital care, seek primary care, or manage symptoms at home.

Results
Data from 281 hospital patients and 300 clinic patients were collected and analyzed. Sensitivity to emergencies was 100% (10/10 encounters). Sensitivity to urgencies was 90% (73/81) and 97% (34/35) for hospital and primary care patients, respectively. The prototype was significantly more accurate than patients at triage (73% versus 58%, p<0.01). Compliance with triage recommendations in this cohort using this iteration of the symptom checker would have reduced hospital visits by 55% but cause potential harm in 2–3% from delay in care.

Interpretation
The prototype symptom checker was superior to patients in deciding the most appropriate treatment setting for medical issues. This symptom checker could reduce a significant number of unnecessary hospital visits, with accuracy and safety outcomes comparable to existing data on telephone triage.
transtextualidad en los títulos de crédito en «The human voice» (2020) de Pedro Almodóvar
Authors: Hornero Campos Virginia 
Published: December 2021

The human voice (Almodóvar, P. 2020) trata sobre la soledad humana, concretamente la femenina, a través del drama y desesperación de una mujer que da todo lo que tiene para mantener su relación amorosa, pero que tampoco duda en cambiar lo que le queda. Estrenada en el Festival de Venecia, es quizás la obra del Pedro Almodóvar donde mejor se puede observar una relación simbiótica en la que la transtextualidad (término y teoría de Gerard Genette comúnmente utilizado en el ámbito literario) trasciende para generar un puzzle en el que el telón de apertura de los títulos de crédito, con una carga identitaria magnánima, dialogará bajo la creatividad de Stvdio Gatti, sobre la cinta del director manchego, sin matizarla ni zcomplementarla.
Ambas partes (títulos y cinta) conversarán de manera lúdica y transversal para des- embocar en la irremediable demostración de que los títulos de crédito en la obra fílmica de Pedro Almodóvar tienen un comportamiento transtextual inequívoco.
Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome
Authors: Koloda Yulia A. , Denisova Yulia V. , Podzolkova Natalia M. 
Published: December 2021

Abstract
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of childbearing, which is defined by the accumulation of multiple, small fluid-filled ovarian cysts without the selection of a single dominant follicle. Most PCOS phenotypes are characterized by the absence of spontaneous ovulation, resistance toward ovulation inductors, the production of a large immature oocytes number, and the high prevalence of ovarian hyperstimulation syndrome, resulting in reduced assisted reproductive technologies (ART) programs effectiveness. The review analyses current data about the relationship between polymorphism genotypes of KISS genes, follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH) and their receptors genes, gonadotropin-releasing hormone (GnRH), estrogen, and progesterone receptors genes, the PCOS risk and the features of ovarian response to stimulation during ART cycles. The use of single nucleotide polymorphisms (SNPs) as prognostic markers of ART programs outcomes would provide a personalized approach to the drugs and doses choice for ovarian stimulation and significantly increase the chance of pregnancy.
Improvements and limits of anti SARS-CoV-2 antibodies assays by WHO (NIBSC 20/136) standardization
Authors: Giavarina Davide , Carta Mariarosa 
Published: December 2021

Abstract

Objectives
A few CLIA automated immunoassays for the recognition of anti S1-RBD SARS-CoV-2 antibodies have recently been placed on the market. Preliminary data demonstrate a high correlation between methods but wide differences in absolute concentrations. A new WHO international standard for anti-SARS-CoV-2 immunoglobulin, NIBSC code 20/136, has been recently introduced to reduce the differences. The aim of this study is thus to verify the harmonization made by NIBSC 20/136 on Ab anti S1-RBD measurement on real samples.

Methods
The following assays were studied: LIAISON® SARS-CoV-2 TrimericS IgG (DiaSorin); Elecsys® anti-SARS-CoV-2 S (ROCHE); Atellica IM SARS-CoV-2 IgG (sCOVG) (Siemens); MAGLUMI® SARS-CoV-2 S-RBD IgG (Snibe), measuring 210 samples from 70 health workers with no previous SARS-CoV2 infection, during their Pfizer-BioNTech’s BNT162b2 vaccination period.

Results
The recalculation of concentrations based on the NIBSC 20/136 standardization improve the analytical and diagnostic comparability but do not cancel this variability between methods: recalibrated results remain different across methods, both in terms of tendency and single data.

Conclusions
The recalculation of concentrations based on the NIBSC 20/136 standardization improves the analytical and diagnostic comparability but does not cancel the differences between methods: recalibrated results remain different across methods, both in terms of tendency and single data.
A New Legal Design for the Credit Reporting Industry
Authors: Buonanno Luigi 
Published: December 2021

Abstract
Under the traditional and well-established conception, credit bureaus are understood as being little more than vessels storing customer data that has been furnished by specific suppliers, such as banks, intermediaries and, more generally, lenders. Accordingly, credit bureaus are deemed to play a ‘neutral’ role in the credit market. Hence, in Europe and the US, they are generally not responsible for any inaccuracies in the information they put into circulation, despite data quality being crucial for the proper functioning of the market and for a fair allocation of resources. This circumstance engenders, however, a conflict between the market interest in accurate data and the ‘endogenous’ for-profit interest of credit bureaus. More specifically, despite their performing an important activity in an oligopolistic environment, credit bureaus are presently allowed to pursue their for-profit interest without any substantial accountability as regards their ‘exogenous’ function of transmitting accurate data. This disequilibrium oftentimes results in under-performance and a low level of data quality. The analysis points out, also through a comparative analysis with the rules governing the US credit report system, how these circumstances in the credit market sector can imperil some pivotal objectives of the EU legal policy, which aims at ensuring equal levels of protection among citizens of Member States within a unique environment dependent on the cross-border exchange of information.
Learning in and through classroom interaction: On the convergence of language and content learning opportunities in subject-matter learning
Authors: Quasthoff Uta , Heller Vivien , Prediger Susanne , Erath Kirstin 
Published: December 2021

AbstractThis study uses an interdisciplinary approach to explore the interplay of linguistic and subject-matter learning. Drawing on previous linguistic work on discourse and genre acquisition, subject-matter teaching as well as the convergence of linguistic and content learning in multilingual classrooms, the study seeks to examine the following questions: (1) How can patterns of classroom talk support or hinder the acquisition of academic discourse competence and subject-matter learning? (2) How are these two learning domains related? The analyses of 120 video-recorded mathematics and German lessons in five classes (n=149 students, 10 teachers) in different German school types revealed two patterns of teacher-student-interaction, which differ in the participatory roles and the (language) learning opportunities they assign to the students. Two larger excerpts from mathematics-lessons are analyzed to illustrate the ways in which linguistic and content learning merge in the two patterns.
Antoninus Pius im Akzeptanzsystem. Ein ‚durchschnittlicher‘ Princeps zwischen dynastischem Prinzip und charismatischer Herrschaft
Authors: Michels Christoph 
Published: December 2021

Zusammenfassung
Die Erforschung antiker Monarchien ist in den letzten Jahrzehnten durch Einbindung herrschaftssoziologischer Konzepte und Fragestellungen wesentlich bereichert worden. Das gilt insbesondere für den römischen Prinzipat, eine monarchische Herrschaftsform sui generis, die aufgrund ihrer inneren Paradoxien mit einer allein rechtlichen Perspektive nicht zu fassen ist. Während dabei bislang vor allem Umbrüche und Krisen und in verschiedener Hinsicht außergewöhnliche Principes im Fokus standen, fragt der Beitrag nach Erkenntnismöglichkeiten entsprechender Modelle für den gemeinhin als wenig beachtenswert eingeschätzten Antoninus Pius (138–161). Akzeptanz seiner – trotz stabiler Herrschaftsordnung – prekären Position musste auch ein ‚durchschnittlicher‘ Princeps wie Pius in einer aktiv zu gestaltenden Kommunikation erwerben, wodurch seine lange Herrschaftszeit erklärungsbedürftig wird. Gegen die von den Quellen nahegelegte personale Perspektive auf Pius’ Regierungsentscheidungen lässt sich zeigen, wie stark sich die herrscherliche Rolle, die sich aus den an den Princeps herangetragenen Erwartungen und Ehrungen der für seine Akzeptanz zentralen Gruppen ergab, auf scheinbar persönliche Entscheidungen auswirkte. Das gängige ‚zivile‘ Bild von Pius’ Herrschaft kann dabei mit Max Webers Konzept der charismatischen Herrschaft insofern differenziert werden, als sich auch dezidiert ‚außeralltägliche‘, in Kontrast zum Bild des civilis princeps stehende Aspekte festmachen lassen. Diese standen indes nicht – wie mitunter in der Forschung postuliert – in Opposition zu dem auch in der Zeit der ‚Adoptivkaiser‘ wirksamen dynastischen Denken.
Interaction among a lump, periodic waves, and kink solutions to the KP-BBM equation
Authors: Li Junjie , Manafian Jalil , Hang Nguyen Thi , Ngoc Huy Dinh Tran , Davidyants Alla 
Published: December 2021

Abstract
The Hirota bilinear method is prepared for searching the diverse soliton solutions to the (2+1)-dimensional Kadomtsev–Petviashvili–Benjamin–Bona–Mahony (KP-BBM) equation. Also, the Hirota bilinear method is used to find the lump and interaction with two stripe soliton solutions. Interaction among lumps, periodic waves, and one-kink soliton solutions are investigated. Also, the solitary wave, periodic wave, and cross-kink wave solutions are examined for the KP-BBM equation. The graphs for various parameters are plotted to contain a 3D plot, contour plot, density plot, and 2D plot. We construct the exact lump and interaction among other types of solutions, by solving the underdetermined nonlinear system of algebraic equations with the associated parameters. Finally, analysis and graphical simulation are presented to show the dynamical characteristics of our solutions, and the interaction behaviors are revealed. The existing conditions are employed to discuss the available got solutions.
“My Skin Is Not Me”: The Transformations of William Shakespeare’s Othello in Ann-Marie MacDonald’sGoodnight Desdemona (Good Morning Juliet)and Djanet Sears’sHarlem Duet
Authors: Sassi Imed 
Published: December 2021

AbstractBothGoodnight Desdemona (Good Morning Juliet)(1990) andHarlem Duet(1997) are Canadian feminist appropriations of William Shakespeare. Both deal, at least partly, withOthello, and both can be considered subversive re-visions of Shakespeare’s play which aim to articulate oppositional intervention in the canon. These similarities notwithstanding, the plays have not often been studied concurrently. Also, while several critics have explored them, mostly separately, in terms of their adaptation/appropriation of Shakespeare, seeking to spell out the transformations they have brought to the “original” text, little has been said about how the iconic figure of Shakespeare still holds sway in these new dramas, albeit in different ways and to varying degrees. Likewise, their dramatization of the character of Othello remains rather understudied. This essay explores the “new” Othellos of the two plays, contending that their positioning in the two texts evinces some similarities while their characterization differs widely, given the plays’ generic difference, but mostly the two playwrights’ rather divergent feminist perspectives which, in turn, substantially shape the plays’ respective appropriation techniques.
This Is England 2021: Staging England and Englishness in Contemporary Theatre
Authors: Edwards Gemma 
Published: December 2021

AbstractThis article explores the ways in which contemporary theatre is engaging with English national questions. In the context of the current devolutionary movements in Britain, I apply a national specificity, focusing on plays and performances which address the politics of just one of the three nations within Britain: England. While this study of the specifics of England and Englishness is already well-established in literary studies (Gardiner) and political science (Kenny; Nairn), there is yet to be a sustained critical engagement with England in theatre studies. Following a discussion of Jez Butterworth’sJerusalem(2009) in light of its planned West End revival in 2022, I then turn to two recent theatrical representations of England in Mike Bartlett’sAlbion(2017 and 2020) and the Young Vic’sMy Englandshorts (2019), which I propose offer more rigorous, reflexive explorations into English national identity. As questions over England’s cultural and political representation become increasingly loaded and difficult to navigate, I suggest that the beginnings of this English national register in the theatre marks an attempt to nuance these debates, opening a productive space for critical inquiry.
Respiration, Heartbeat, and Conscious Tactile Perception
Authors: Grund Martin , Al Esra , Pabst Marc , Dabbagh Alice , Stephani Tilman , Nierhaus Till , Gaebler Michael , Villringer Arno 
Published: December 2021

Previous studies have shown that timing of sensory stimulation during the cardiac cycle interacts with perception. Given the natural coupling of respiration and cardiac activity, we investigated here their joint effects on tactile perception. Forty-one healthy female and male human participants reported conscious perception of finger near-threshold electrical pulses (33% null trials) and decision confidence while electrocardiography, respiratory activity, and finger photoplethysmography were recorded. Participants adapted their respiratory cycle to expected stimulus onsets to preferentially occur during late inspiration/early expiration. This closely matched heart rate variation (sinus arrhythmia) across the respiratory cycle such that most frequent stimulation onsets occurred during the period of highest heart rate probably indicating highest alertness and cortical excitability. Tactile detection rate was highest during the first quadrant after expiration onset. Interindividually, stronger respiratory phase-locking to the task was associated with higher detection rates. Regarding the cardiac cycle, we confirmed previous findings that tactile detection rate was higher during diastole than systole and newly specified its minimum at 250–300 ms after the R-peak corresponding to the pulse wave arrival in the finger. Expectation of stimulation induced a transient heart deceleration which was more pronounced for unconfident decision ratings. Interindividually, stronger poststimulus modulations of heart rate were linked to higher detection rates. In summary, we demonstrate how tuning to the respiratory cycle and integration of respiratory-cardiac signals are used to optimize performance of a tactile detection task.SIGNIFICANCE STATEMENTMechanistic studies on perception and cognition tend to focus on the brain neglecting contributions of the body. Here, we investigated how respiration and heartbeat influence tactile perception: respiration phase-locking to expected stimulus onsets corresponds to highest heart rate (and presumably alertness/cortical excitability) and correlates with detection performance. Tactile detection varies across the heart cycle with a minimum when the pulse reaches the finger and a maximum in diastole. Taken together with our previous finding of unchanged early event-related potentials across the cardiac cycle, we conclude that these effects are not a peripheral physiological artifact but a result of cognitive processes that model our body's internal state, make predictions to guide behavior, and might also tune respiration to serve the task.
Community Health Worker Intervention to Address Social Determinants of Health for Children Hospitalized With Asthma
Authors: Schechter Sarah B. , Lakhaney Divya , Peretz Patricia J. , Matiz Luz Adriana 
Published: December 2021

BACKGROUND
Social determinants of health (SDOH) contribute to racial disparities in asthma outcomes. Community health worker (CHW) programs represent a promising way to screen for SDOH and connect patients to resources, but the impact of CHW programs in the inpatient pediatric setting has been examined in few studies. In this study, we aimed to evaluate a CHW program for children hospitalized with asthma in a predominantly Hispanic community by examining rates of SDOH and social resource navigation.

METHODS
This pilot study involved a CHW intervention to improve pediatric asthma care. Patients were included if they were hospitalized with asthma over an 18-month period and enrolled in the CHW program during their hospitalization. In an intake interview, CHWs screened caregivers for SDOH and provided tailored social resource navigation. Descriptive statistics were used to assess rates of social risk factors and social resource navigation.

RESULTS
Eighty patients underwent SDOH screening. The majority of patients were Hispanic (81.3%, n = 65). Half of caregivers reported food or housing insecurity over the past 12 months (50.0%, n = 40), and most reported inadequate housing conditions (63.8%, n = 51). CHWs coordinated social resources for the majority of families (98.8%, n = 79), with the most common being food resources (42.5%, n = 34), housing resources (82.5%, n = 66), and appointment navigation (41.3%, n = 33).

CONCLUSIONS
CHWs identified a high burden of unmet social needs and provided associated social resource navigation in a largely Hispanic pediatric population hospitalized for asthma. CHW programs have potential to improve asthma outcomes by linking high-risk patients with social resources.
The effect of recycled tyre steel fibers on the properties of concrete
Authors: Senesavath Souphavanh , Salem Ali , Kashkash Saied , Zehra Bintul , Orban Zoltan 
Published: December 2021

Abstract
Steel fibers recovered from recycled tires were considered for use as reinforcement in concrete to improve the tensile properties of concrete as well as being an economically viable and environmentally friendly alternative. This paper investigates the effect of purified and non-purified recycled tire steel fiber in concrete with a constant fiber proportion of 30 kg m−3 to determine properties in fresh and hardened concrete. The results indicate that concrete with purified tire fibers have better tensile properties than those with non-purified tire fibers. Density, strength, and toughness significantly increase but workability tends to decrease when using recycled tire steel fiber as reinforcement in concrete.
TSH DÜZEYİ NORMAL, DÜŞÜK VE YÜKSEK HASTALARDA VÜCUT KİTLE İNDEKSLERİNE GÖRE HDL DÜZEYLERİNİN KARŞILAŞTIRILMASI
Authors: KAYA ZAMAN Ferda 
Published: December 2021

Amaç
Obezite dünyada prevelansı gittikçe artan bir sağlık
problemidir. Obezite ayrıca dislipideminin önemli nedenlerinden
biridir Son yıllarda tiroid hormon düzeyleri
ve vücut kitle indekslerini (VKİ) karşılaştıran pek
çok çalışma vardır. Ayrıca tiroid hormon testleri ve
lipid profilini inceleyen çalışmalarda mevcuttur. Bu
çalışmanın amacı, erişkin bireylerde Tiroid Stimulan
Hormon (TSH) düzeyleri normal, düşük ya da yüksek
olmasının vücut kitle indeksine göre Yüksek Dansiteli
Lipoprotein (HDL) düzeylerine etkisinin değerlendirilmesidir.
Gereç ve Yöntem
Çalışma retrospektif olarak veri analiz yöntemiyle dizayn
edildi. Aralık 2016- Eylül 2020 tarihleri arasında
özel bir üniversite hastanesinin Checkup polikliniğine
başvurmuş; Herhangi bir tiroid ilacı kullanmayan,
TSH, VKİ, HDL değerleri bakılmış, 18 yaş üstü bireylerin
verileri toplandı(n=1621). Sosyo-demografik veri
olarak ayrıca her hasta için yaş ve cinsiyet verileri
de kaydedildi. Veriler SPSS 25.0 paket programıyla
analiz edildi. Sürekli değişkenler ortalama ± standart
sapma ve ortanca (min, maks), kategorik değişkenler
ise sayı ve yüzde olarak ifade edildi. Verilerin normal
dağılıma uygunluğu Kolmogorov Smirnov testi ve
histogramlar ile incelendi. Bağımsız grup incelemelerinde;
Mann Whitney U testi ve Kruskal Wallis Varyans
Analizi (post hoc: Bonferroni düzeltmeli Mann
Whitney U testi) kullanıldı. Kategorik değişkenler arasındaki
farklılıkların incelenmesinde ise Ki kare testi
kullanıldı. Tüm analizlerde p0,05).
Sonuç
Çalışmamızda normal kilolu olan kişiler arasında TSH
değeri normal olanların HDL değerleri, TSH değeri
yüksek olanlara göre anlamlı şekilde düşük bulundu.
Bu konuda hem erişkin hem çocuklarda yapılan bazı
çalışmalar olsa da hala araştırmaya açık bir konudur.
Bu alanda yapılacak yeni çalışmalar ile konu hakkında
daha ayrıntılı ilişkiler saptanabilecektir.