bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis
Authors: Duan Nai-fan , Liu Bin , Li Xiao-na , Xiong Yi-bai , Zhang Yan , Zhang Chi , LI Li , Lu Cheng , Lyu Jueni 
Published: August 2021

Background: Recently, Chinese patent medicines (CPMs) have been widely used to treat children with influenza in China, with curative effects. Therefore, the efficacy and safety of such treatment require further evaluation. The present meta-analysis integrated data from several independent studies to determine overall treatment trends in children with influenza.Methods: The following databases were searched for randomized controlled trials (RCTs) published from their inception to December 12, 2020: CNKI, Wanfang, SinoMed, PubMed, Cochrane library, and Embase. Two researchers independently extracted the data, assessed the methodological quality of the studies, and conducted a meta-analysis of the results using Review Manager 5.2. The results were assessed using forest plots, and publication bias was evaluated using a funnel plot.Results: A total of 21 RCTs involving 2960 cases were included. Compared to oseltamivir alone, CPMs combined with oseltamivir reduced the duration of symptoms, including that of fever (mean difference [MD] = −0.64, 95% confidence interval [CI]: −0.86 to −0.41, P &lt; 0.00001), cough (MD = −0.82, 95% CI: −1.02 to −0.62, P &lt; 0.00001), nasal obstruction (MD = −0.88, 95% CI: −1.15 to −0.61, P &lt; 0.00001), and sore throat (MD = −0.92, 95% CI: −1.26 to −0.57, P &lt; 0.00001). Combined therapy also reduced the time of viral shedding (MD = −0.53, 95% CI: −0.70 to −0.36, P &lt; 0.00001) and the occurrence of adverse drug reactions (ADRs) (RR=0.53, 95% CI: 0.34 to 0.83, P = 0.005).Conclusions: CPMs combined with oseltamivir reduced the duration of symptoms, shortened the time of viral shedding, and reduced the number of ADRs. However, these results should be considered with caution because there was marked heterogeneity and publication bias in the research data. More rigorous RCTs should be designed to verify the effect of CPMs in children with influenza.
Greater than the Sum: Applying Daily-Dose Equivalents to Antipsychotic Prescription Claims to Study Real-World Effects
Authors: Hayes Kaleen N. , Gomes Tara , Tadrous Mina 
Published: August 2021

Traditional methods to standardize exposures in pharmacoepidemiologic studies, like defined daily-doses, may be inadequate to capture drug class effects when there are many in-class medications, formulations, and administration routes. Antipsychotic medications are one example of a drug class with these complexities. Direct dose conversion methods are pharmacologically-based but often overlooked, potentially for lack of real-world guidance and examples of their implementation. The purpose of this article is to describe a method to implement dose conversion, using an example study that quantifies antipsychotic use among a cohort of older adults with dementia. We identified 45,442 older adults (aged ≥66 years) with dementia initiating antipsychotic therapy between January 1, 2009 and December 31, 2012 in Ontario, Canada using linked administrative healthcare databases. We developed and applied a data cleaning and dose conversion algorithm to quantify antipsychotic exposure in chlorpromazine dose equivalents at initiation, month 6, and month 12 of therapy. Results were stratified by route of administration. At initiation, 14% of patients received multiple antipsychotic prescriptions simultaneously. Patients initiating regular injectable and multiple administration routes received the highest median chlorpromazine equivalent daily-doses. Data cleaning changed 3, 16, 36, and 42% of total equivalent daily-doses in patients initiating oral, regular injectable, long-acting injectable, and multiple administration routes, respectively. Dose conversion of prescription claims data was a feasible method to quantify and present antipsychotic drug exposures. Dose conversion methods can be considered for drug effects studies of antipsychotic therapies and other medication classes with complex use.
Intestinal Barrier Dysfunction Exacerbates Neuroinflammation via the TLR4 Pathway in Mice With Heart Failure
Authors: Huo Jun-Yu , Jiang Wan-Ying , Yin Ting , Xu Hai , Lyu Yi-Ting , Chen Yuan-Yuan , Chen Meng , Geng Jie , Jiang Zhi-Xin , Shan Qi-Jun 
Published: August 2021

AimsThe present study aimed to investigate alterations in neuroinflammation after heart failure (HF) and explore the potential mechanisms.MethodsMale wild-type (WT) and Toll-like receptor 4 (TLR4)-knockout (KO) mice were subjected to sham operation or ligation of the left anterior descending coronary artery to induce HF. 8 weeks later, cardiac functions were analyzed by echocardiography, and intestinal barrier functions were examined by measuring tight junction protein expression, intestinal permeability and plasma metabolite levels. Alterations in neuroinflammation in the brain were examined by measuring microglial activation, inflammatory cytokine levels and the proinflammatory signaling pathway. The intestinal barrier protector intestinal alkaline phosphatase (IAP) and intestinal homeostasis inhibitor L-phenylalanine (L-Phe) were used to examine the relationship between intestinal barrier dysfunction and neuroinflammation in mice with HF.ResultsEight weeks later, WT mice with HF displayed obvious increases in intestinal permeability and plasma lipopolysaccharide (LPS) levels, which were accompanied by elevated expression of TLR4 in the brain and enhanced neuroinflammation. Treatment with the intestinal barrier protector IAP significantly attenuated neuroinflammation after HF while effectively increasing plasma LPS levels. TLR4-KO mice showed significant improvements in HF-induced neuroinflammation, which was not markedly affected by intestinal barrier inhibitors or protectors.ConclusionHF could induce intestinal barrier dysfunction and increase gut-to-blood translocation of LPS, which could further promote neuroinflammation through the TLR4 pathway.
Financial and Mental Health Concerns of Impoverished Urban-Dwelling Bangladeshi People During COVID-19
Authors: Islam Md. Saiful , Rahman Md. Estiar , Banik Rajon , Emran Md. Galib Ishraq , Saiara Noshin , Hossain Sahadat , Hasan M. Tasdik , Sikder Md. Tajuddin , Smith Lee , Potenza Marc N. 
Published: August 2021

Background: The COVID-19 pandemic has impacted the physical, mental and financial health of many individuals. Individuals living in impoverished crowded settings may be particularly vulnerable to COVID-19-related stressors. How substantially marginalized groups like impoverished urban-dwelling individuals have been impacted during this pandemic is poorly understood. The present study aimed to investigate the associated factors of financial concerns and symptoms of depression and posttraumatic stress disorder (PTSD) during the COVID-19 pandemic among impoverished urban-dwelling individuals residing in Dhaka, Bangladesh.Methods: A cross-sectional survey was conducted between August and September 2020 using face-to-face interviews in six disadvantaged neighborhoods (“slums”) in Dhaka. Individuals were interviewed using a semi-structured questionnaire consisting of questions assessing socio-demographics, lifestyle, financial well-being relating to the COVID-19 pandemic, depression, and PTSD.Results: Four-hundred-and-thirty-five individuals (male = 54.7%; mean age = 45.0 ± 12.0 years; age range = 18–85 years) participated. Most (96.3%) reported that their household income decreased due to the COVID-19 pandemic. Factors associated with decreased household incomes included female gender, primary education, joblessness, food scarcity and depression. Depression symptoms were linked to female gender, joblessness, divorce, living in a joint family, excessive sleep and smoking. Low incomes, excessive sleep, joblessness and food scarcity were positively associated with PTSD symptoms. In contrast, less sleep appeared protective against PTSD.Conclusions: Public health initiatives, in particular mental health services that target stress and biocentric approaches that consider how humans interact with multiple facets of nature, should be introduced to mitigate against potential financial and psychological effects of the pandemic on impoverished urban-dwelling individuals in Bangladesh.
Depression-, Anxiety-, and Anger and Cognitive Functions: Findings From a Longitudinal Prospective Study
Authors: Lindert Jutta , Paul Kimberley C. , Lachman Margie E. , Ritz Beate , Seeman Teresa E. 
Published: August 2021

Background: Determinants of changes in cognitive function during aging are not well-understood. We aimed to estimate the effects of depression-, anxiety- and anger symptoms on cognition and on cognition changes, especially on changes in episodic memory (EM) and executive functioning (EF).Methods: We analyze data from the Mid-Life in the Midlife in the United States Biomarker study at two time points including n = 710 women, and n = 542 men (1996/1997) at the first assessment and n = 669 women, and n = 514 men at the second assessment (2013/2014). To assess cognition we used the Brief Test of Adult Cognition (BTACT). To measure depression-, anxiety- and anger symptoms we used the Mood and Anxiety Symptom Questionnaire (MASQ), the Center for Epidemiologic Studies Depression Scale (CES-D) and the State-Trait Anger Expression Inventory (STAXI). We used repeated models analyses to explore changes in cognition, and repeated measures linear mixed-effects models to investigate depression, anxiety and anger effects on cognition. All analyses were adjusted for potential confounders (cognition at baseline, age, education, income).Results: At the first assessment, women had significantly better episodic memory functioning than men; men in the oldest age group had significant better executive functioning. At the second assessment, more education, and white ethnicity were associated with less negative changes on episodic memory and executive functioning. Depression- and anger symptoms were associated with declines in episodic memory among women; anxiety symptoms were associated with declines in episodic memory and executive functioning in both gender in men (EF: β: −0.02, (95% CI: −0.03, −0.01; EM: β −0.02 (−0.02, 95% CI: −0.03, −0.01) and in women (EF: β −0.01, 95% CI: −0.02, −0.0004; EM: β −0.013, 95% CI: −0.03, −0.001).Conclusions: Depression-, anxiety- and anger symptoms were associated with changes in episodic memory and executive functioning. Further longitudinal studies are critical in populations in more countries to better understand the impact of depression, anxiety and anger symptoms on cognition changes.
FUTURE SOCIAL WORKER TRAINING IN FACILITATION INTERACTION WITH PEOPLE OF DIFFERENT AGES AND SOCIAL STATUS
Authors: Strelnikov V. 
Published: August 2021

The article describes the peculiarities of future social worker training in facilitation interaction with people of different ages and social status; it is shown how the technologies of ‘dyad interaction’ and future specialists in social work situational training are applied on the basis of facilitation; an analysis of their implementation in the practice of future social worker training in facilitation interaction with people of different ages and social status is given.
The aim of the paper is to summarize the practical work of researchers from English-speaking countries on the effective use of postclassical didactics (‘dyad interaction’ and situational learning) in the practice of social worker training in facilitation interaction with people of different ages and social status.
The essence of ‘case-method technology implementation in the practice of future social worker training in facilitation interaction with people of different ages and social status is contained; it is contained in a change of the purpose of training (awareness that there is a possibility of many solutions in social and social-pedagogical work of; democratic nature of the process of acquiring knowledge, equality with other participants, in particular with the lecturer, when the main thing is to develop in the process of co-creation of the future specialist in social work with the lecturer new knowledge, skills of facilitation interaction with people of different ages and social status; the method on the basis of which the system of values of future specialists in social work as facilitators develops, their facilitation positions, life attitudes, a kind of professional worldview, etc. are formed).
A description of the functional forms and qualities of dyad interaction is presented. Considering the relative compactness and simplicity, they are used by lecturers in the process of future social worker training in facilitation interaction with people of different ages and social status. It has improved the quality of the lecturer’s dyad interaction with future social workers.
MANIFESTAÇÕES NEUROLÓGICAS EM PACIENTES QUE CONTRAÍRAM COVID-19: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Godoy Jhonson Tizzo , Dutra Milla Giancristofaro , Agnolin Alexandre Antonio , Avila Ana Teresa Bittencourt , Faccio Carolina Bohn , Souza Elaine Maria , de Almeida Giovana Lima , Feitosa Karen Karollinne Dikauá Santos , Lopes Larissa Magalhães de Moraes , de Oliveira Maria Luiza Franco , Aguiar Sthefanie Ferreira Caires 
Published: August 2021

INTRODUÇÃO: O espectro da infecção do SARS-CoV-2 é amplo e predomina o acometimento respiratório. Estudos recentes, no entanto, têm demonstrado cada vez mais o acometimento extra respiratório, incluindo alterações neurológicas diversas. A presente revisão discorre sobre as principais manifestações neurológicas decorrentes da infecção por SARS-CoV-2 e suas consequências para os infectados. METODOLOGIA: Trata-se de uma revisão integrativa da literatura. As bases de dados utilizadas foram MEDLINE/PubMed, Scielo e LILACS. Os seguintes descritores foram utilizados: “Neurological manifestations”, “COVID-19” e “Neurological symptoms”. RESULTADOS: No mundo foram reportadas diversas manifestações neurológicas como as centrais (cefaleia, tontura, convulsões, meningite/encefalite, déficit cognitivo, AVC), periféricas (analgesia, anosmia) e musculoesqueléticas. As mais frequentemente observadas foram tontura e cefaléia. DISCUSSÃO: O mecanismo de neuro invasão ainda não está totalmente esclarecido, mas as evidências mostram que se deve haver lesão direta, imunomediada ou decorrente de hipóxia, além de eventos secundários relacionados a distúrbios sistêmicos, como sepse, hiperpirexia hipercoagulabilidade etc. A agressividade dos sintomas pode variar desde as mais leves até predispor manifestações graves como doenças cerebrovasculares agudas. CONCLUSÃO: As manifestações neurológicas apresentaram-se sob diferentes formas e ainda são necessários mais ensaios clínicos para analisar a fisiopatologia do SARS-CoV-2 no sistema nervoso, assim como suas consequências tardias.
Hubungan antara Grit Terhadap Penyesuaian Diri Siswa Boarding School
Authors: Hanifah Raidah , Mujidin M , Diponegoro Ahmad Muhammad 
Published: August 2021

The transition period for school change has an impact on students. This study aims to determine the relationship between grit and self-adjustment of students who carry out the boarding school program in the tenth grade in Yogyakarta. Using cluster random sampling technique, this research was conducted at three middle schools in tenth grade students who conducted a boarding school program with a total of 117 students. The measuring instrument in this study used a grit scale and a self adjustment scale. Data analysis using mement product correlation. The results showed that the coefficient between grit andself-adjustment was 0.316 with a significance level of 0.001 (p <0.01). It is concluded that there is a very significant positiverelationship between grit and self-adjustment of tenth grade boarding school students in Yogyakarta. So, the higher the grit,the higher the student's adjustment
Penilaian Kawasan Perumahan dengan Pendekatan Konsep Berkelanjutan (Greenship Neighborhood Assessment)
Authors: Sapitri  , Aziz Zarnold 
Published: August 2021

Global warming and environmental degradation are still being issues in various countries, including Indonesia. It has been causing the climate change. In 2015 the United Nations started a program called Sustainable Development Goals (SDGs). One of the goals was to tackle climate change. In order to encourage the implementation of SDGs, an effort that could conduct was the realization of green housing areas. An assesment is needed to make sure that sustainable development in neighborhood is implemented well and correct. Green Building Council Indonesia (GBCI) has published a rating system called Greenship Neighborhood as a reference for assessing the concept of sustainable development neighbourhood. The purpose of this study was to find out how the implementation of Greenship Neighbourhood and how much value is achieved in Citraland residential area. The method that used were descriptive qualitative and quantitative. Descriptive qualitative was a description of the research object conditions, while descriptive quantitative was output assessments numbers based on the Greenship Neighborhood assessment tool. There were seven aspects that assessed i.e. land ecological enhancement, movement and connectivity, water management and conservation, solid and material waste, community wellbeing strategy, buildings and energy, and innovation future development. The results of research showed that there were six of the seven assessment categories have been applied in the object area. Generaly, the total value is 36 out of 124, with percentage achieved 29%. Based on these result, Citraland Pekanbaru residential area did not meet the minimum standard for the application of Greenship Neigborhood according to GBCI.
Impact of Accreditation Certification on Improving Healthcare Quality and Patient Safety at Johns Hopkins Aramco Healthcare
Authors: Al-Sayedahmed Huda , Al-Tawfiq Jaffar , Al-Dossary Basma , Al-Yami Saeed 
Published: August 2021

ABSTRACT

Introduction
Accreditation gained worldwide attention as a means of increasing awareness of medical errors, improving healthcare quality, and ensuring a culture of safety. Johns Hopkins Aramco Healthcare has been accredited by Joint Commission International (JCI) since 2002. The aim of this study was to evaluate the effect of the accreditation process on healthcare quality performance by maintaining compliance with the requirements of JCI's international patient safety goals (IPSGs) over a 4-year period and how this was reflected by patient safety and satisfaction.

Methods
In Johns Hopkins Aramco Healthcare, the six JCI IPSGs are part of the as key performance indicators that reflect organizational performance in different services. For this study, data from January 2017 to the end of 2020 were analyzed apropos performance and correlation with patient experience.

Results
The IPSGs data analysis showed that general performance was maintained above the target values (&gt; 90%–96%) in all IPSGs. This was significantly reflected in high patient satisfaction during this period, with Pearson correlation of 0.9 and p &lt; 0.000.

Conclusions
Maintaining accreditation status over time enhances patients' confidence in an organization and its leadership as providers of safe, quality healthcare services. However, individual staff perception, commitment, accountability, and responsibility have an influence on performance, the organization's accreditation status, and patients' experiences.
Crashing Project Evaluation by Managing Allocation Resource and Cost using CPM-PERT and MS,Project in Nurul Hayat Mosque’s Renovation
Authors: Athira Nur Rizka , Andris Dea Ayu Maharani , Khoiroh Siti Muhimatul 
Published: August 2021

The implementation of project management must be calculated based on time and cost estimation. One of the efficiency measures that can take is to accelerate. Time, cost, and quality are factors that must consider while making project acceleration. Project renovation in Nurul Hayat's room was chosen in this research because this project experienced delays in implementation. Delays occur due to a lack of available manpower. This delay will certainly have an impact on costs. The purpose of this research is to speed up time and get optimum costs while still paying attention to quality standards. By CPM-PERT approach, and the evaluation of project acceleration with Ms. Project, the results obtained are scheduling the initial completion of the mosque renovation which initially has an estimated 42 days with a normal total cost of 17,227,500, can be accelerated for 36 working days with additional processing costs of Rp. 70,000 and overtime costs of Rp. 1,635,000. The total cost is Rp 18,932,500
Keyword: Crashing Project, CPM-PERT, Ms. Project
Bidding Models Analysis on Ship Repair Projects (Friedman and Ackoff & Sasieni Models)
Authors: Maharani Aditya , Hardiyati Fitri , Subagyo Ali 
Published: August 2021

The existence of a ship project carried out with a tender system by the LPSE allows all shipyard industries to bid on the project, this causes the chances of winning to become smaller, the determination of the tender price greatly determines the size of the profit that can be obtained and the percentage of the possibility of winning the project in a shipping industry. Therefore, the strategy of determining the bid price is very important. The statistical method used is multi discrete distribution, and multi normal distribution, while the bidding model uses Friedman (1956) and Ackoff & Sasieni (1968) models.
The results obtained the best bid price strategy to win an auction or tender is the model that produces the lowest optimum mark-up, namely the Friedman model with multi normal distribution, while for Ackoff & Sasieni it produces a higher bid than the Friedman model except in certain company conditions.
Thermodynamic Studies on the Sorption of Lead (II), Chromium (III) and Manganese (II) ions onto Acid-Activated Shale
Authors: Ilaboya I. R. , Okpoko J. S. 
Published: August 2021

Shale mineral in its raw form was collected, processed, calcinated and activated using tetraoxosulphate (VI) acid. The microstructural arrangement and chemical composition of the raw, calcinated and acid-activated shale was determined using x-ray fluorescence and scanning electron microscope to verify its ability for the removal of Pb2+, Cr3+ and Mn2+ from wastewater. Batch experimental method was used to study the effect of different adsorption parameters on the sorption efficiency of shale. The effect of temperature on the sorption of Pb2+, Cr3+ and Mn2+ on acid-activated shale was investigated at varied temperature of 15 – 40 . The calculated value of enthalpy () was 12.50 kJ/mol for Pb2+ adsorption, 5 kJ/mol for Cr3+ and 11 kJ/mol for Mn2+ adsorption. The calculated values of Gibbs free energy () varies from -6.576 kJ/mol to 1.358 kJ/mol for Pb2+ adsorptions, from -2.696 kJ/mol to 0.192 kJ/mol for Cr3+ adsorptions, and -4.994 kJ/mol to 1.870 kJ/mol for Mn2+ adsorptions. The entropy () range is 38.68 – 60.946 kJ/mol for Pb2+ adsorptions, 16.69 – 24.58 kJ/mol for Cr3+ adsorptions, and 31.70 – 51.10 kJ/mol for Mn2+ adsorptions. The positive value of shows that the adsorption of Pb2+, Cr3+ and Mn2+ onto acid-activated shale was an endothermic process. The values of are negative at temperature of 298 K and above for the three metal ions studied, which confirmed that the adsorption of Pb2+, Cr3+ and Mn2+ on acid-activated shale was a spontaneous process. The decline in with increasing adsorption temperature showed that adsorptions of Pb2+, Cr3+ and Mn2+ onto acid-activated shale became better at higher temperature while the positive value of for all metal ions studied showed the amplified arbitrariness at the solid-solution interface during the fixation of the adsorbate on the active site of acid-activated shale.