bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping white matter maturational processes and degrees on neonates by diffusion kurtosis imaging with multiparametric analysis
Authors: Li Xianjun , Li Mengxuan , Wang Miaomiao , Wu Fan , Liu Heng , Sun Qinli , Zhang Yuli , Liu Congcong , Jin Chao , Yang Jian 
Published: October 2021

AbstractWhite matter maturation has been characterized by diffusion tensor (DT) metrics. However, maturational processes and degrees are not fully investigated due to limitations of univariate approaches and limited specificity/sensitivity. Diffusion kurtosis imaging (DKI) provides kurtosis tensor (KT) and white matter tract integrity (WMTI) metrics, besides DT metrics. Therefore, we tried to investigate performances of DKI with the multiparametric analysis in characterizing white matter maturation. Developmental changes in metrics were investigated by using tract‐based spatial statistics and the region of interest analysis on 50 neonates with postmenstrual age (PMA) from 37.43 to 43.57 weeks. Changes in metrics were combined into various patterns to reveal different maturational processes. Mahalanobis distance based on DT metrics (DM,DT) and that combing DT and KT metrics (DM,DT‐KT) were computed, separately. Performances of DM,DT‐KT and DM,DT were compared in revealing correlations with PMA and the neurobehavioral score. Compared with DT metrics, WMTI metrics demonstrated additional changing patterns. Furthermore, variations of DM,DT‐KT across regions were in agreement with the maturational sequence. Additionally, DM,DT‐KT demonstrated stronger negative correlations with PMA and the neurobehavioral score in more regions than DM,DT. Results suggest that DKI with the multiparametric analysis benefits the understanding of white matter maturational processes and degrees on neonates.
Mental health in the UK Biobank: A roadmap to self‐report measures and neuroimaging correlates
Authors: Dutt Rosie K , Hannon Kayla , Easley Ty O , Griffis Joseph C , Zhang Wei , Bijsterbosch Janine D 
Published: October 2021

AbstractThe UK Biobank (UKB) is a highly promising dataset for brain biomarker research into population mental health due to its unprecedented sample size and extensive phenotypic, imaging, and biological measurements. In this study, we aimed to provide a shared foundation for UKB neuroimaging research into mental health with a focus on anxiety and depression. We compared UKB self‐report measures and revealed important timing effects between scan acquisition and separate online acquisition of some mental health measures. To overcome these timing effects, we introduced and validated the Recent Depressive Symptoms (RDS‐4) score which we recommend for state‐dependent and longitudinal research in the UKB. We furthermore tested univariate and multivariate associations between brain imaging‐derived phenotypes (IDPs) and mental health. Our results showed a significant multivariate relationship between IDPs and mental health, which was replicable. Conversely, effect sizes for individual IDPs were small. Test–retest reliability of IDPs was stronger for measures of brain structure than for measures of brain function. Taken together, these results provide benchmarks and guidelines for future UKB research into brain biomarkers of mental health.
High trans‐2‐Decalones by Photoredox Catalyzed β‐Isomerization
Authors: Sombret Juliette , Quintaine Julie , Biremond Tony , Barnes Quentin , de Saint‐Laumer Jean‐Yves , Saudan Lionel 
Published: October 2021

AbstractThe synergistic combination of three catalytic processes – photoredox, enamine and hydrogen atom transfer (HAT) catalysis – enabled the β‐isomerization of 2‐decalones towards the thermodynamically most stable trans‐isomers. A library of iridium (III) complexes and organic dyes were screened in combination with cyclic amines and thiols which after optimization gave the desired trans‐2‐decalones with high trans/cis ratios of 60 : 40 up to 98 : 2.
Strategic analysis of providing corporate sustainability open data
Authors: Helbig Raphaela , von Höveling Sven , Solsbach Andreas , Marx Gómez Jorge 
Published: October 2021

SummaryHow companies report their data is undergoing digitization and sustainable transformation. Sustainability is important; therefore, various stakeholders are interested in sustainability information. Companies provide the required information and strive toward the use of information systems to ensure efficient data processing. A possible approach for information provision is open data. This research introduces the idea of corporate sustainability open data (CSOD) as one new mechanism of companies' sustainability self‐reporting. Since CSOD is not yet commonly practiced by companies, a strategic analysis of the situation and its possible consequences is conducted with an analysis of strengths, weaknesses, opportunities, and threats. This research provides an overview of companies' sustainable development through open data. Moreover, it identifies drivers, challenges, and reasonable strategies for CSOD adoption. Thus, the research contributes to the establishment of an innovative application of open data in the private sector to support sustainable transformation worldwide.
Teaching Driving Literacies in a Community Language School
Authors: Lorimer Leonard Rebecca , Gear Caroline 
Published: October 2021

AbstractThis case study describes the dynamics of a literacy curriculum that was collaboratively designed at a community language school. The curriculum teaches participants how to get a driver’s license in Massachusetts, focusing on the English language literacies necessary for passing the written and road tests. This case study describes the curriculum’s context, framework, and goals, and then details how the curriculum was designed and experienced by its students and teachers. Participants’ insights show that literacies as seemingly incidental as those required for driving can be deeply meaningful, requiring attention to how literacy is experienced by bodies, in motion.
Immigration Stories to Reveal Funds of Knowledge and Brave Spaces in Literacy Curriculum
Authors: McNeill Erin 
Published: October 2021

AbstractThe purpose of this practitioner inquiry study was to learn from students as they shared their life experiences, drawing from their stories to develop curriculum and instruction in an English learner classroom. The project argues that when relationships are prioritized with diverse students using a pedagogy of acompañamiento, classrooms become spaces where students can share family stories, life experiences, and funds of knowledge. In this article, year one of the study, Rabia’s immigration story focused on her father’s journey to America while a classmate created a presentation about the same journey from Rabia’s perspective. Data was coded for accompaniment and funds of knowledge, then classified into emerging themes. Recommendations for literacy practice include projects focused on family and community in literacy curriculum, a need for brave spaces, where courage and understanding may be necessary when sharing sensitive information with new audiences and a recognition of how immigration shapes lives.
Designing Classroom Practices for Teaching Online Inquiry: Experiences from the Field
Authors: Kiili Carita , Lakkala Minna , Ilomäki Liisa , Toom Auli , Coiro Julie , Hämäläinen Elina , Sormunen Eero 
Published: October 2021

AbstractStudents face several challenges when asked to locate relevant and credible information from the internet. This article introduces three principles for designing online inquiry lessons and documents what we learned from five language arts teachers from Finland who implemented and provided feedback on a learning unit framed in those design principles. Teachers implemented a researcher‐designed online inquiry unit in nine upper secondary school classrooms. The unit included four 75‐minute lessons sequenced to support the location, evaluation, and synthesis of information students encountered in an online inquiry task. Teachers’ diaries revealed their impressions of the unit, problems encountered, and exceptions made to the designed plan. Follow‐up interviews revealed additional insights about appropriate time allocation, clear instruction, and areas where students benefit from explicit guidance in strategy use. Findings suggest a researcher‐teacher collaboration can be a fruitful endeavor to assist in advancing the design of productive online inquiry activities.
Common factors of commodity prices
Authors: Delle Chiaie Simona , Ferrara Laurent , Giannone Domenico 
Published: October 2021

SummaryIn this paper, we extract latent factors from a large cross‐section of commodity prices, including fuel and non‐fuel commodities. We decompose each commodity price series into a global (or common) component, block‐specific components, and a purely idiosyncratic component. We find that the bulk of the fluctuations in commodity prices are well summarized by a single global factor. This global factor is closely related to fluctuations in global economic activity and, since the early 2000s, has become more important in explaining variations in commodity prices.
Three‐dimensional bioprinting of polysaccharide‐based self‐healing hydrogels with dual cross‐linking
Authors: Kim Hyun Seung , Kim Chunggoo , Lee Kuen Yong 
Published: October 2021

AbstractThree‐dimensional (3D) bioprinting technique is useful to fabricate constructs with functional and biological structures for various biomedical applications. Oxidized hyaluronate (OHA) and glycol chitosan (GC) can form autonomous self‐healing hydrogels when adipic acid dihydrazide (ADH) is used. We demonstrate that hyaluronate–alginate hybrid (HAH) polymers can be used for secondary physical cross‐linking of OHA/GC/ADH hydrogel with calcium ions after 3D printing. The molecular weight of hyaluronate can be varied while keeping the molecular weight of alginate in HAH. The mechanical stiffness and stability of gels after 3D printing are strongly dependent on the molecular weight of HAH at the same cross‐linking density. In vitro chondrogenic differentiation of ATDC5 cells encapsulated in 3D‐printed constructs is dependent on the molecular weight of HAH in gels. This dual cross‐linking system consisting of naturally occurring biocompatible polysaccharides may have potential in the 3D bioprinting of custom‐made scaffolds for tissue engineering applications.
Long non‐coding RNA NEAT1 and its targets (microRNA‐21 and microRNA‐125a) in rheumatoid arthritis: Altered expression and potential to monitor disease activity and treatment outcome
Authors: Yang Junfeng , Wang Shanfu , Liu Lei , Wang Jianwei , Shao Yang 
Published: October 2021

AbstractBackgroundThe present study aimed to explore the association of long non‐coding RNA nuclear‐enriched abundant transcript 1 (lnc‐NEAT1) with inflammation, disease activity, treatment outcome, and its targets (microRNA [miR]‐21 and miR‐125a) in patients with rheumatoid arthritis (RA).MethodsPeripheral blood mononuclear cells were sampled from 130 RA patients at baseline, week (W) 6, and W12, as well as from 60 healthy controls (HCs) after enrollment. Meanwhile, the expressions of lnc‐NEAT1, miR‐21, and miR‐125a were detected by reverse transcription‐quantitative polymerase chain reaction.Resultslnc‐NEAT1 was elevated, but miR‐21 and miR‐125a were declined in RA patients compared with HCs (all p < 0.001); meanwhile, lnc‐NEAT1 was negatively correlated with miR‐21 and miR‐125a (both p < 0.05) in RA patients. Besides, elevated lnc‐NEAT1 but declined miR‐21 and miR‐125a were correlated with erythrocyte sedimentation rate (ESR) and C‐reactive protein and the 28‐joint Disease Activity‐ESR score (all p < 0.05) in RA patients. Moreover, lnc‐NEAT1 was declined from baseline to W12 in RA patients (p < 0.001). Additionally, lnc‐NEAT1 at W12 was declined in response patients compared with non‐response patients (p = 0.006), and also decreased in remission patients compared with non‐remission patients (p < 0.001).Conclusionlnc‐NEAT1 and its targets (miR‐21 and miR‐125a) correlate with RA risk and disease activity, and declined lnc‐NEAT1 associates with better treatment outcome to some extent in RA patients, suggesting that lnc‐NEAT1 might be a potential biomarker to monitor disease activity and treatment outcome in RA.
A longitudinal investigation of the meaning‐making model in midlife adults who have experienced trauma
Authors: Fitzke Reagan E. , Marsh Dylan R. , Prince Mark A. 
Published: October 2021

AbstractIntroductionPark and Folkman's (1997) meaning‐making model posits that distress from traumatic events stems from discrepancies between one's global meaning framework and appraised situational meaning of the traumatic event, with meaning making diminishing these discrepancies and thus bolstering well‐being. The current study investigates this supposition over a 19‐year span in mid‐life adults.MethodsWe selected participants from the Midlife in the United States (MIDUS) study who had indicated the experience of a negatively impactful traumatic event (N = 1687). We hypothesized that increased positive reappraisal (a type of meaning making) would have an indirect effect on positive and negative affect through the three dimensions of meaning in life (significance, coherence, and purpose).ResultsAll direct and indirect effects were significant and supported hypotheses.ConclusionResults suggest that the assertions of the meaning‐making model hold true over a period of nearly two decades among mid‐life adults who have experienced traumatic events.
A unique sarcopenic progression in the mouse rotator cuff
Authors: Meyer Gretchen A. , Shen Karen C. 
Published: October 2021

AbstractBackgroundIn response to chronic injury, the muscles of the rotator cuff (RC) experience a unique degeneration characterized by extensive fatty infiltration and loss of contractile function. Human studies suggest this degeneration is also a feature of RC sarcopenia and may precede RC injury. In this study, we investigated whether RC muscles exhibit a similar unique sarcopenia in the mouse.MethodsMale and female mice were subdivided into four age groups: 3, 9, 18, and 24 months. The supraspinatus (SS) and infraspinatus muscles of the RC and the tibialis anterior (TA) muscle of the hindlimb were assessed. Muscle mass, contractile function, fibre cross‐sectional areas and numbers, fatty infiltration, and fibrosis were assessed at each time point. Targeted transcriptional analyses were performed to assess the role of metabolic and inflammatory derangement in the pathology.ResultsThe 24‐month‐aged female mice exhibited decreased mass (25% lower than at 9 and 18 months, P < 0.01) in all muscles tested. However, only RC muscles also exhibited decreased contractile tension at this time point (20% lower than at 18 months, P < 0.005). Similarly, only female RC muscles exhibited increased fatty infiltration at 24 months (20% higher than 9 months, P < 0.05) and had elevated transcriptional markers of adipogenesis (2.4‐fold higher Pparg and 3.8‐fold higher Adipoq expression compared with 9 months, P < 0.001). Unbiased metabolic transcriptional profiling identified up‐regulation of the antigen presentation (Z scores of 2.3 and 1.9 for SS and TA, respectively) and cytokine and chemokine signalling (Z scores of 3.1 and 2.4 for SS and TA, respectively) pathways in 24 month female muscle compared with 9. Further transcriptional analysis supported increased expression of pro‐adipogenic inflammatory signals (6.3‐fold increase in Il6 and 5.0‐fold increase in Anxa2, P < 0.01) and increased presence of fibro‐adipogenic progenitors (2.5‐fold) in the 24‐month‐aged female RC compared with 9 months that together exacerbate fatty infiltration.ConclusionsThese data indicate that female mice replicate the unique sarcopenic pathology in the ageing human RC. Furthermore, they suggest that the exacerbated fatty infiltration is due to an interaction between higher resident fibro‐adipogenic progenitor numbers and an elevated systemic inflammation in aged female mice. We conclude that female mouse RC muscle is a novel system to study both human RC degeneration and the signals that regulate sarcopenic fatty infiltration in general, which is prevalent in humans but largely absent from the rodent hindlimb.
Associations between inflammatory markers, body composition, and physical function: the Copenhagen Sarcopenia Study
Authors: Kamper Rikke S. , Alcazar Julian , Andersen Lars L. , Haddock Bryan , Jørgensen Niklas Rye , Hovind Peter , Suetta Charlotte 
Published: October 2021

AbstractBackgroundChronic low‐grade inflammation has been suggested as one of the key elements in the development of sarcopenia, but in contrast to disease‐related loss of muscle mass, the role of chronic low‐grade inflammation in age‐related (primary) sarcopenia is still not clear. The aim of this study was to investigate low‐grade inflammation in relation to age and the potential association between inflammatory biomarkers and body composition, muscle strength and physical performance in a healthy Danish cohort.MethodsThere were 1160 generally healthy men and women (range: 22–93 years) included. Appendicular lean mass (ALM) and visceral fat normalized to height (kg/m2) was assessed by dual‐energy X‐ray absorptiometry (iDXA, GE Lunar). Muscle strength and physical performance were evaluated by handgrip strength (HGS), 30 s sit‐to‐stand performance, and maximal gait speed (GS). Systemic levels of TNF‐α, IL‐6, IL‐1β, IL‐4, IL‐13, and IFN‐γ were measured using multiplex bead‐based immunoassays (Bio‐Rad). hsCRP was assessed using latex particle‐enhanced immunoturbidimetric assays (Roche Diagnostics).ResultsWith age, ALM/h2, HGS, sit‐to‐stand performance and GS decreased, whereas visceral fat/h2 increased in both men and women (P < 0.05). Systemic levels of hsCRP, TNF‐α, IL‐4, and IFN‐γ increased with age in men and women (P < 0.05), while IL‐1β increased in women only (P < 0.01). Higher levels of hsCRP were associated with lower ALM/h2 in elderly (≥65 years) men and women (P < 0.001). Higher levels of hsCRP were associated with lower handgrip strength in elderly women (P < 0.05) whereas higher levels of hsCRP was not associated with lower HGS in elderly men (P = 0.056). Higher levels of hsCRP were associated with lower GS (P < 0.05), whereas IFN‐γ was positively associated with GS in elderly women (P < 0.05), but not elderly men. Visceral fat index was positively associated with hsCRP in elderly men and women (P < 0.001). Compared with elderly with normal HGS, elderly men and women with low HGS displayed higher levels of TNF‐α and hsCRP (P < 0.05).ConclusionsWith age, systemic levels of hsCRP, TNF‐α, IL‐4, and IFN‐γ increased, with hsCRP and TNF‐α being especially elevated in more physically frail elderly supporting the association between low‐grade systemic inflammation and poor physical function. In contrast, only high levels of hsCRP were weakly associated with low muscle mass and positively associated with visceral fat and low physical function, suggesting that chronic low‐grade inflammation is not the main driver of age‐related loss of muscle mass as previously suggested.
Subcutaneous fat area at the upper thigh level is a useful prognostic marker in the elderly with femur fracture
Authors: Kim Youn‐Jung , Seo Dong‐Woo , Ko Yousun , Hong Seok‐In , Kim Kyung Won , Kim Won Young 
Published: October 2021

AbstractBackgroundThe aim of this study was to evaluate prognostic value of body tissue composition at the upper thigh level for 1 year mortality in elderly patients with proximal femur fracture.MethodsThis retrospective cohort study included consecutive elderly (aged ≥65) patients diagnosed with proximal femur fracture based on the findings of pelvic bone computed tomography (CT) performed at the emergency department of a tertiary care hospital and treated with surgery between 2010 and 2017. The cross‐sectional area of subcutaneous fat and skeletal muscle at the upper thigh level was measured using CT. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for 1 year mortality were estimated using a Cox proportional hazards model. Survival based on the SFA quartiles was assessed using nonparametric Kaplan–Meier survival analysis and compared used log‐rank tests.ResultsAmong 876 elderly patients included in this study, the median age was 79.0 years, and 646 (73.7%) patients were female. A total of 93 (10.6%) died within 1 year after admission to the emergency department. Survivors had a significantly higher median subcutaneous fat area (SFA) than non‐survivors (170.2 vs. 133.0 cm2, P < 0.001), but no significant difference was observed between the skeletal muscle area (median, 156.7 vs. 160.3 cm2, P = 0.504) and muscle density (median, 19.0 vs. 19.1 HU, P = 0.861) of both groups. After adjustment of other clinical characteristics and body compositions, the multivariate Cox proportional hazard analysis showed that SFA (adjusted HR, 0.987; 95% CI, 0.982–0.992; P < 0.001) was independently associated with 1 year mortality. With 384 deaths during 51 322 person‐months of follow‐up, the median estimated survival duration of all the patients was 92.8 months (95% CI, 80.8–104.7 months). The patients with SFA in the third (165.6–195.0 cm2) and fourth (>195.0 cm2) quartiles showed significantly longer survival duration than those with SFA in the first (<131.4 cm2; median survival time, 51.3 months) and second (131.4–165.5 cm2; median survival time, 88.7 months) quartiles (P < 0.001 by log‐rank test).ConclusionsThe SFAs measured at the upper thigh level and 1 year mortality are positively associated in elderly patients with proximal femur fracture. SFA may be an independent prognostic biomarker for 1 year mortality of femur fracture.
Alpha‐fetoprotein and focal nodular hyperplasia: An unconventional couple
Authors: Carrier Paul , Guyot Anne , Debette‐Gratien Marilyne , Fredon Fabien , Teissier Marie‐Pierre , Labrousse François , Loustaud‐Ratti Véronique 
Published: October 2021

AbstractWe report the case of a 36‐year‐old patient who was initially managed for gynecomastia. The first biological analyses showed a moderately elevated alpha‐fetoprotein (AFP) level. After an endocrine etiology was excluded, an abdominal computed tomography scan showed typical focal nodular hyperplasia (FNH) proven by biopsy and showing expression of AFP in FNH cells. After follow‐up for 24 months, the serum AFP and liver radiology remained unchanged. The association between an elevated AFP and FNH is rarely described in the medical literature.