bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online Balint Group Work Versus Pharmacotherapy in Treatment of Coronavirus Anxiety in Healthcare Workers in Iran: A Pilot Randomized Controlled Trial
Authors: shahini najmeh , gholamzad shakiba , salimi zanireh , Dehkordi Mansoureh Kiani , Khaniki Saeedeh Hajebi , Oskoei Reza Rahimzadeh , Ardabili Hossein Mohaddes 
Published: September 2021

Abstract
Background: An increase in symptoms of anxiety is already being reported in relation to the COVID-19 pandemic.Objectives: We aimed to compare the effectiveness of Balint group work with pharmacotherapy in coronavirus related anxiety among healthcare workers (HCWs) in Iran.Methods: In This pilot clinical trial, after passing a phone screening procedure by a psychiatrist, subjects were quasi-randomly assigned to Balint (8 sixty-minute online sessions) or pharmacotherapy (Sertraline) groups. Both groups were asked to fill two questionnaires, including the Corona Disease Anxiety Scale (CDAS) and Connor-Davidson resilience scale (CD-RISC), at the beginning and the end of the 4-week intervention period.Results: A total of 45 HCWs enrolled in this study. The results showed a significant difference between the post-test and pre-test scores of both groups in the total scores of anxiety and its subcomponents (p≤0.001). There was no significant difference between the effectiveness of the two interventions on anxiety (p=0.52). Both interventions had a significant effect on the subjects' resilience and its subscales (p≤0.05) except for positive acceptance change. The spiritual influences domain had a significantly higher increase in the pharmacotherapy group (P=0.031).Conclusions: We showed Balint group work maybe can better to pharmacotherapy with Sertraline in management of COVID-19 related anxiety and boosting resilience in healthcare workers.
Novel Preclinical Human Salivary Gland Cancer Models Established Using Organoid Culture And Patient-Derived Xenografting
Authors: Aizawa Yoshihiro , Takada Kentaro , Aoyama Jun , Sano Daisuke , Yamanaka Shoji , Seki Masahide , Kuze Yuta , Ramilowski Jordan , Okuda Ryo , Ueno Yasuharu , Nojima Yusuke , Inayama Yoshiaki , Hatakeyama Hiromitsu , Hatano Takashi , Takahashi Hideaki , Nishimura Goshi , Fujii Satoshi , Suzuki Yutaka , Taniguchi Hideki , Oridate Nobuhiko 
Published: September 2021

Abstract
Salivary gland carcinoma (SGC) has poor prognosis depending on the histological subtype. However, due to the scarcity of preclinical experimental models, its pathogenesis remains largely unknown, hampering the development of new treatment modalities for patients with these malignancies. Here, we first report the establishment of a large collection of human SGC experimental models for multiple histological subtypes using patient-derived xenograft (PDX) and organoid culture techniques with our previously optimized method. Additionally, we successfully generated organoids by culturing established PDXs (PDX-derived organoids). Through passaging, each pre-clinical model was confirmed to maintain the pathological characteristics of the original tumor and the genetic traits of corresponding histological subtypes. Finally, we confirmed that these organoids were available for pharmacologic studies. Thus, our comprehensive models of SGC could be a powerful resource for the development of novel therapeutic agents and investigating the pathogenesis of these malignancies.
Exclusive Enteral Nutrition Promotes Clinical Remission and Mucosal Healing of Southern China Pediatric Crohn’s Disease in Short Time
Authors: Xiong Liya , Chen Peiyu , Xie Jing , Ren Lu , Wang Hongli , Xu Qian , Yuan Linqing , Wu Peiqun , Wei Lijuan , Li Huiwen , Geng Lanlan , Gong Sitang 
Published: September 2021

Abstract
Background: this study aimed to understand the effective of exclusive enteral nutrition on clinical remission and mucosal healing with pediatric Crohn’s disease (CD)in a real-world setting in southern China. Methods: In this prospective disease registry, children (aged between 2 and 18years)with newly diagnosed luminal CD were recruited from December 2018 to December 2020. Patients were examined at baseline and at weeks3 and 8 of EEN induction. Logistic regression analysis is used to assess the influencing factors of EEN. Results: The clinical remission and mucosal healing rate of children is 76.5%、35% separately after 8 week induction. The remission rate of mild CD is higher than that of moderate-severe CD, but it is not statistically significant(p=0.01). Disease location、age、the response rate at week 3 all do not predict the effectiveness of EEN treatment.Conclusions: EEN can effectively promote clinical remission and mucosal healing of southern China pediatric Crohn’s disease in short time and is also recommend as the first-line therapy for children with severe luminal CD
Compound Traditional Chinese Medicine Dermatitis Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules in AD
Authors: Zhang Rongrong , Shao Shuai , Shen Yingxin , Sun Jiaming , Piao Songlan , Zhao Daqing , Li Guangzhe , yan mingming 
Published: September 2021

Abstract
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by an itchy and scaly rash. Compound traditional Chinese medicine dermatitis ointment (CTCMDO) is a traditional classics aimed at AD composed of a mixture of extracts from five plants known to have anti-inflammatory and antiallergic effects. Materials and methods: In this study, we used HPLC and LC/MS to analyze the effective components of CTCMDO in detail and establish its HPLC fingerprint analysis. On this basis, this article studied the anti-inflammatory and antipruritic activities of CTCMDO in the treatment of DNCB-induced AD in mice.Results: Through comparison with literature data, a total of 43 compounds were identified, including phenylpropionic acid compounds; alkaloid compounds; curcumin compounds and lignans. On this basis, a fingerprint with 17 common peaks was established. In AD-like mice, CTCMDO treatment suppressed the scratching behavior induced by DNCB in a dose-dependent manner and inhibited the production of Th1/2 cytokines in serum. CTCMDO treatment reversed the up regulation of P substance levels of itch-related genes in the skin. Furthermore, CTCMDO suppressed the phosphorylation of JNK、ERK and p38 in the skin. Conclusion: In all, our work indicated that CTCMDO can signifificantly attenuate the pathological alterations of Th1/2 cytokines and itch-related mediators, and inhibit the phosphorylation of MAPKs to treat AD.
Performance Improvements of Hemispherical Solar Still Using Internal Reflector: Energy and Exergy Analysis
Authors: Attia Mohammed El Hadi , Athikesavan Muthu Manokar , Kaliyamoorthy Murugan , Balachandran Guruprasad , Kutbudeen Syed Jafar , Sathyamurthy Ravishankar 
Published: September 2021

Abstract
Various scientists are looking for effective and easy solutions for augmentation of yield from the Hemispherical Solar Still (HSS). In this study, aluminium foil-sheet was used to reflect the intensity hence augments the evaporation rate and daily yield. Experimentations were conducted on two SS: the first SS is HSS; the second SS is HSS with reflective aluminium foil-sheet walls (HSS-RAFW). The highest distilled water production from the HSS, HSS-RAFW are 3.36 and 4.1 kg/m2, respectively. Compared to the HSS, the yield of distilled water was augmented by 22.21% when using the HSS- RAFW. The daily energy and exergy efficiency (EnE and ExE) of the HSS is 26.27 and 1.04%, respectively and daily EnE and ExE of the HSS-RAFW is 32.75 and 1.71%, respectively.
Use of Lignosulfonate from Pulping Industrial Waste as a Potential Material for Proton Exchange Membrane in Fuel Cell
Authors: Liang Hunan , Zhu Guodong , Li Yan , Yu Dayu , Shang Wei 
Published: September 2021

Abstract
A polymer membrane as a proton exchange membrane (PEM) used in fuel cell is prepared by blending lignosulfonate (LS) from sulfite pulp industrial waste with sulphonated poly (ether ether ketone) (SPEEK). Different contents of LS ranging from 0 to 20% (w/w) were blended with SPEEK to measure the influence of LS content on performance of membrane. The results indicated that the proton conductivity of the prepared membrane was increased with the content of LS in membrane. For as-prepared membrane containing 15% LS, the proton conductivity is remarkably higher than that of membrane fabricated by sulfonated poly (aryl ether ketone) at the same test conditions. Nevertheless, the physical strength decreased as the LS content increased. Comprehensively, the blending membrane containing 15% LS can satisfy the PEM application, which implyes LS as a potential candidate for PEM application in a low temperature range.
Feasibility of a web-based stress management intervention for university students in Indonesia
Authors: Juniar Dilfa , Ballegooijen Wouter van , Schulte Mieke H.J. , Schaik Anneke van , Passchier Jan , Heber Elena , Lehr Dirk , Sadarjoen Sawitri Supardi , Riper Heleen 
Published: September 2021

Abstract
Background

University students are susceptible to excessive stress. A web-based stress management intervention holds promise to improve stress but is still at a novel stage in Indonesia. This present paper reports the feasibility of the intervention we developed ( ‘Rileks’ ) among university students in Indonesia in terms of acceptability and usability, and to propose recommendations for future improvements.

Methods

A single-group pre-test and post-test design was used. Participants with DASS-42 Stress scale score ≥ 15 were given access to the intervention (N= 68). The main outcome measures were the Client Satisfaction Questionnaire-8 (CSQ-8), the System Usability Scale (SUS), and intervention uptake. Participants’ experience in each session was evaluated using closed and open-ended questions for future improvements. Descriptive statistics were used to examine primary outcome and qualitative session evaluations. Participants’ responses to each topic of the open questions were summarized.

Results

The intervention was evaluated as being satisfactory (CSQ-8 average score 21.89 (SD 8.72), range 8-32). However, the intervention’s usability was still below expectation (SUS average score 62.8 (SD 14.74), range 0-100). The core modules were completed by 10 participants (14.7%) and the study drop out rate was 63.23% at post-assessment. The module content was rated generally positively with some notes for improvement covering content and technical aspects.

Conclusions

The study indicates that Rileks is potentially feasible for Indonesian university students. In order to be optimally applied in such context and before scaling up web-based intervention in general in Indonesia a further development and refinement are needed.
Changes in Televisit Modalities Due to the Covid-Pandemic in Chile: A Comparison of Patient Satisfaction.
Authors: Constanzo Freddy , Aracena-Sherck Paula , Benavides Luis , Garcés Jorge , Villalobos Rodrigo , Marrugo Mery , Kuzmanic Katia , Caamaño Ramón , Peña Lorena , Silva César , Alvarado Cristobal 
Published: September 2021

Abstract
BACKROUND: The corona virus 2019 (COVID-19) pandemic has impacted healthcare guidelines and modalities of patient consultation worldwide. The frequent cycles of quarantine confinement in Chile has caused mobility restrictions for both patients and physicians, which forced the Hospital Las Higueras de Talcahuano (HHT) to replace the assisted televisit modality with a more classic televisit program. This change may have impacted the satisfaction of patients.METHODS: Patient’s perception of satisfaction was evaluated through self-administered survey questionnaires, previously validated in the Spanish language. Cohorts were grouped according to two relational models:i) Assisted televisit, 503 neurology patients during the years 2018-2019; and ii) Televisit, 831 patients from different specialtiestreated during 2020. Perception of satisfaction was compared by gender, age, and type of televisit, and internal consistency (Cronbach alpha) and reliability (factorial analysis of main components) were assessed. RESULTS: Assisted televisit and televisit cohortswere composed by 64.2% and 67.6% women, respectively; patients under 65 years of age were 62.2% and 75%, respectively. Assisted televisit patients showed very high 94.4% (n=475) and high 5.2% (n=26) satisfaction levels, while televisit patients showed very high 22.3% (n=185), high 63.9% (n=531), and moderate 13.1% (n=109) satisfaction levels; this difference is statistically significant at p<0.001. Questionnaires showed excellent internal consistency, and all items showed point biserial correlations greater than 0.30. CONCLUSION: Lower perception of satisfaction due to the change in televisit relational modality underscores the importance of primary care professionals, who support the specialist inthe assisted televisit model. The results of this study suggest that assisted televisit contributes to delivering an integrative solution that helps to alleviate the fragmentation of the system.
Utilization of Antenatal Care Among Adolescent and Young Mothers in Ghana; Analysis of The 2017/18 Multiple Indicator Cluster Survey
Authors: Anaba Emmanuel Anongeba , Alor Stanley Kofi , Badzi Caroline Dinam 
Published: September 2021

Abstract
Background Complications during pregnancy and childbirth are the leading cause of death among adolescent girls. In Ghana, the prevalence of adolescent pregnancy remains high. Yet, little is known about ANC utilization among adolescents and young mothers. This study aimed to assess the prevalence of obtaining 4 or more ANC visits, and associated factors among adolescent and young mothers. Methods We analysed secondary data from the sixth round of the Ghana Multiple Indicator Cluster Survey 2017/18. A total of 947 adolescent and young mothers were included in this study. Data were analysed using STATA/SE, version 16, employing descriptive statistics and Multiple Logistic Regression. Results It was found the majority of the participants were aged 20-24 years (70%), married/in union (61%) and non-insured (64%). The prevalence of obtaining 4 or more ANC visits was 84%. Adolescent and young mothers with junior high school education, in the second wealth quintile, exposed to the internet, and resided in the Upper East Region had a higher likelihood of obtaining 4 or more ANC visits (p < 0.05). Conclusions This study demonstrated that optimal ANC utilization among adolescent and young mothers were determined by socio-economic factors. Going forward, maternal healthcare interventions must prioritize adolescent and young mothers from poor socio-economic backgrounds.
Evidence of Accelerated Epigenetic Aging of Breast Tissues In Patients With Breast Cancer Is Driven By CpGs Associated With Polycomb Related Genes
Authors: Rozenblit Mariya , Hofstatter Erin , Liu Zuyun , O'Meara Tess , Storniolo Anna Maria , Dalela Disha , Singh Vineet , Pusztai Lajos , Levine Morgan 
Published: September 2021

Abstract
Purpose: Age is one of the strongest risk factors for the development of breast cancer, however the underlying etiology linking age and breast cancer remains unclear. We have previously observed links between epigenetic aging signatures in breast/tumor tissue and breast cancer risk/prevalence. However, these DNA methylation-based aging biomarkers capture diverse epigenetic phenomena and it is not known to what degree they relate to breast cancer risk, and/or progression. Methods: Using six epigenetic clocks, we analyzed whether they distinguish normal breast tissue adjacent to tumor (cases) vs normal breast tissue from healthy controls (controls). Results: The Levine (p=0.0037) and Yang clocks (p=0.023) showed significant epigenetic age acceleration in cases vs controls in breast tissue. We observed that much of the difference between cases and controls is driven by CpGs associated with polycomb related genes. Thus, we developed a new score utilizing only CpGs associated with polycomb related genes and demonstrated that it robustly captured epigenetic age acceleration in cases vs controls (p=0.00012). Finally, we tested whether this same signal could be seen in peripheral blood. We observed no difference in cases vs. controls and no correlation between matched tissue/blood samples, suggesting that peripheral blood is not a good surrogate marker for epigenetic age acceleration. Conclusions: Moving forward, it will be critical for studies to elucidate whether epigenetic age acceleration in breast tissue precedes breast cancer diagnosis and whether methylation changes at CpGs associated with polycomb related genes can be used to assess the risk of developing breast cancer among unaffected individuals.
Existence, Fate And Risk Assessment of Pharmaceuticals During Treatment of Domestic Wastewater: Mass Flow And Consumption Calculation
Authors: Badawy Mohamed I. , El-Gohary Fatma A. , Abdel-Wahed Mahmoud S. , Gad-Allah Tarek A. , Ali Mohamed Eid 
Published: September 2021

Abstract
In Egypt, pharmaceuticals consumption is dramatically increasing, owing to the population growth and the unrestricted sale manner. Therefore, the occurrence and fate of nine pharmaceutical compounds (PhCs) were scrutinized at the different stages of sewage treatment plant (STP) in Giza, Egypt. Levels of these PhCs were assessed in wastewater and sludge phases by a high-performance liquid chromatography coupled. Nine PhCs were detected in both wastewater and sludge. Average concentration of the total PhCs detected in influent, primary sedimentation effluent and final effluent were 227, 155 and 89 µg/L, respectively. The overall removal efficiency of the individual PhCs ranged from 18 % to 72 % removal. The occurrence trend revealed that biodegradation and sorption are the concurrently removal mechanisms of the studied PhCs. As well, the calculated total mass load of individual PhCs were in the range 328 – 42256, 152 – 26180, and 257 – 6625 g d-1 for influent, effluent and sludge. Meanwhile, the calculated range of personal mass load of the individual PhCs was 193 – 15274, 120 – 10864 and 34 - 265 µg d-1 Pe-1, for the influent, the final effluent and the sludge, respectively. The overall personal pharmaceutical consumption per day in West of Greater Cairo was estimated based on influent concentration of STP. Sulfamethoxazole, paracetamol and diclofenac were identified with the highest levels in the influent of STP, PSE and FE as well as in the dewatered sludge. Furthermore, the high concentrations of these compounds in the sludge confirms the sorption pathway removal of PhCs. Generally, the average daily and annual consumption per capita of the most dominant PhCs in wastewater; sulfamethazole, paracetamol and diclofenac are 60.09, 34.79, and 26.69 mg d-1 Pe-1 and 22, 12.52, and 12.52 g y-1 Pe-1, respectively. Moreover, risk assessment (RQ) for the detected PhCs in FE is greatly higher than the predicted non-effect concentration (PNEC). Conclusively, the FE of STP is considered a risky source for PhCs in adjacent surface water.
Neonatal Circumcision Availability in the United States: A Physician Survey
Authors: Naha Ushasi , Arora Hans , Walton Ryan , Rosoklija Ilina , Skibley Lindsay , Johnson Emilie 
Published: September 2021

Abstract
Background: A significant proportion of boys present to surgical specialists later in infancy/early childhood for elective operative circumcision despite the higher procedural risks. This study aims to assess physician perspectives on access to neonatal circumcision (NC) across the United States and identify potential reasons contributing to disparities in access. Methods: A cross-sectional survey was electronically distributed to physician members of the Societies for Pediatric Urology and the American Academy of Pediatrics Section on Hospital Medicine. Hospital characteristics and circumcision practices were assessed. Associations between NC availability and institutional characteristics were evaluated using chi-squared testing and multivariable logistic regression. Qualitative analyses of free-text comments were performed. Results: A total of 367 physicians responded (129 urologists [41%], 188 pediatric hospitalists [59%])). NC was available at 86% of hospitals represented. On univariate and multivariate analysis, the 50 hospitals who did not offer NC were more likely to be located in the Western region (odds ratio [OR]=8.33; 95% confidence interval [CI]=3.1-25 vs Midwest) and in an urban area (OR=4.2; 95% CI=1.6-10 vs suburban/rural) compared with hospitals that offered NC. Most common reasons for lack of availability included not a birth hospital (N=22, 47%), lack of insurance coverage (N=8, 17%), and low insurance reimbursement (N=7, 15%). Institutional, regional, or provider availability (68%), insurance/payment (12.4%), and ethics (12.4%) were common themes in the qualitative comments.Conclusions: Overall availability of neonatal circumcision varied based on hospital characteristics, including geography. Information from this survey will inform development of interventions designed to offer NC equitably and comprehensively.
The Effect of Inoculation With Amycolatopsis Strains On Yield and Nutrient Content of Wheat (Triticum Aestivum L.) and Soil Microbiological Properties
Authors: Kussainova Maira , Kızılkaya Rıdvan 
Published: September 2021

Abstract
In this study, the yield and nutrient content of wheat (Triticum aestivum L.) grown in greenhouse conditions and soil microbiological properties were investigated. Inoculating Amycolatopsis strains, including A.magusensis DSM 45510T, A.orientalis DSM 40040T, and A.azurea DSM 43854T was considered. The mixture of wheat straw (WS) was used to increase soil organic matter content by 5%. It was determined that the grain and straw yield of wheat increased significantly (P < 0.001) in inoculation with Amycolatopsis strains in soils without WS. However, inoculation with Amycolatopsis strains in soil with WS significantly decreased grain and straw of wheat yield. Also, it was found that soil microbial biomass and soil basal respiration (SBR) increased in inoculation with Amycolatopsis strains in both soils with and without WS. While it was established that Cmic:Corg ratio of the control group in the soil samples at the end of the harvest was 1.23, infusing with Amycolatopsis strains was observed to be around 2.95–3.31. Moreover, inoculation with Amycolatopsis strains in soils with WS varied between 0.32–0.40. In the same way, it was determined the microbial metabolic quotient (qCO2) was 2.58 in the control group. This meaning was between 5.67–5.82 in infusing with Amycolatopsis strains and 6.04–6.41 in inoculating with Amycolatopsis strains in soils mixed with ground wheat stalk. As a result, it suggested that the yield of wheat could be increased inoculation with A.magusensis, A.orientalis, and A.azurea, from Amycolatopsis strains, in soils with low soil organic matter content and soils that cannot be shown an increment in terms of organic matter content.