bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Options for the Management of Aromatase Inhibitor-
Associated Bone Loss
Authors: Gaudio Agostino , Xourafa Anastasia , Rapisarda Rosario , Castellino Pietro 
Published: August 2021

Background:
Breast cancer is the most commonly occurring cancer in women worldwide.
Early breast cancer is a kind of invasive neoplasm that has not proliferated beyond the breast
or the axillary lymph nodes. Current therapeutic strategies for breast cancer mainly include local
therapies such as surgery or radiotherapy and systemic therapies like chemotherapy, endocrine, and
targeted therapy. Nowadays, the adjuvant treatment for hormone receptor-positive early breast cancer
in postmenopausal women remains the main effective systemic therapy which can improve disease-
free survival and overall survival; it involves several endocrine treatment regimens, including
Selective Estrogen Receptor Modulators (SERMs), Aromatase Inhibitors (AIs), or a combination
of them. AIs have been shown to be more effective in preventing recurrence in postmenopausal women
with early breast cancer when compared with tamoxifen, thus representing the standard of
care for adjuvant endocrine therapy. Although AIs are usually well-tolerated, they can have some
side effects. Apart from the appearance of arthralgias or myalgias and cardiovascular events, AI
therapies, reducing already low endogenous postmenopausal estradiol levels, cause increased bone
loss and increase fracture risk in postmenopausal women.

Objectives:
The objective of this review is to evaluate the therapeutic options in the management
of Aromatase Inhibitor-Associated Bone Loss (AIBL).

Methods:
We reviewed the current literature dealing with different therapeutic options in the treatment
of AIBL.

Results:
Clinical practice guidelines recommend a careful evaluation of skeletal health in all women
with breast cancer before AI therapy initiation. Adequate calcium and vitamin D intake have also
been suggested. Pharmacological attempts to minimize AI-related bone loss have focused on the
use of antiresorptive agents, such as bisphosphonates and denosumab to protect bone integrity and
reduce the risk of fractures. Furthermore, clinical trials have shown that by making the bone microenvironment
less susceptible to breast cancer metastasis, these drugs are able to increase disease-
free survival.

Conclusions:
AI, that are the pillar of the systemic treatment for patients with hormone receptor--
positive breast cancer, are associated with different side effects, and in particular, osteoporosis and
fractures. Both bisphosphonates and denosumab are able to prevent this negative effect.
Anti-Diabetic Drugs GLP-1 Agonists and DPP-4 Inhibitors may Represent
Potential Therapeutic Approaches for COVID-19
Authors: Alshanwani Aliah , Kashour Tarek , Badr Amira 
Published: August 2021

:
The fast spread of coronavirus 2019 (COVID-19) calls for immediate action to counter
the associated significant loss of human life and deep economic impact. Certain patient populations
like those with obesity and diabetes are at higher risk for acquiring severe COVID-19 disease and
have a higher risk of COVID-19 associated mortality. In the absence of an effective and safe
vaccine, the only immediate promising approach is to repurpose an existing approved drug. Several
drugs have been proposed and tested as adjunctive therapy for COVID-19. Among these drugs are
the glucagon-like peptide-1 (GLP-1) 2 agonists and the dipeptidylpeptidase-4 (DPP-4) inhibitors.
Beyond their glucose-lowering effects, these drugs have several pleiotropic protective properties,
which include cardioprotective effects, anti-inflammatory and immunomodulatory activities, antifibrotic
effects, antithrombotic effects, and vascular endothelial protective properties. This narrative
review discusses these protective properties and addresses their scientific plausibility for their potential
use as adjunctive therapy for COVID-19 disease.
Determinants of Use of the Care Information Exchange Portal: Cross-sectional Study
Authors: Neves Ana Luisa , Smalley Katelyn R , Freise Lisa , Harrison Paul , Darzi Ara , Mayer Erik K 
Published: August 2021

Background
Sharing electronic health records with patients has been shown to improve patient safety and quality of care. Patient portals represent a convenient tool to enhance patient access to their own health care data. However, the success of portals will only be possible through sustained adoption by its end users: the patients. A better understanding of the characteristics of users and nonusers is critical for understanding which groups remain excluded from using such tools.

Objective
This study aims to identify the determinants of the use of the Care Information Exchange, a shared patient portal program in the United Kingdom.

Methods
A cross-sectional study was conducted using a web-based questionnaire. Information collected included age, gender, ethnicity, educational level, health status, postcode, and digital literacy. Registered individuals were defined as having had an account created in the portal, independent of their actual use of the platform; users were defined as having ever used the portal. Multivariate logistic regression was used to model the probability of being a user. Statistical analysis was performed in R and Tableau was used to create maps of the proportion of Care Information Exchange users by postcode area.

Results
A total of 1083 participants replied to the survey (186% of the estimated minimum target sample). The proportion of users was 61.58% (667/1083). Among these, most (385/667, 57.7%) used the portal at least once a month. To characterize the system’s users and nonusers, we performed a subanalysis of the sample, including only participants who had provided at least information regarding gender and age. The subanalysis included 650 individuals (389/650, 59.8% women; 551/650, 84.8% >40 years). Most participants were White (498/650, 76.6%) and resided in London (420/650, 64.6%). Individuals with a higher educational degree (undergraduate and professional, or postgraduate and higher) had higher odds of being a portal user (adjusted odds ratio [OR] 1.58, 95% CI 1.04-2.39 and OR 2.38, 95% CI 1.42-4.02, respectively) compared with those with a secondary degree or below. Higher digital literacy scores (≥30) were associated with higher odds of being a user (adjusted OR 2.96, 95% CI 2.02-4.35). Those with a good overall health status had lower odds of being a user (adjusted OR 0.58, 95% CI 0.37-0.91).

Conclusions
This work adds to the growing body of evidence highlighting the importance of educational aspects (educational level and digital literacy) in the adoption of patient portals. Further research should not only describe but also systematically address these inequalities through patient-centered interventions aimed at reducing the digital divide. Health care providers and policy makers must partner in investing and delivering strategic programs that improve access to technology and digital literacy in an effort to improve digital inclusion and reduce inequities in the delivery of care.
Clinical Utility of Wearable Sensors and Patient-Reported Surveys in Patients With Schizophrenia: Noninterventional, Observational Study
Authors: Lahti Adrienne C , Wang Dai , Pei Huiling , Baker Susan , Narayan Vaibhav A 
Published: August 2021

Background
Relapse in schizophrenia may be preceded by early warning signs of biological, sensory, and clinical status. Early detection of warning signs may facilitate intervention and prevent relapses.

Objective
This study aims to investigate the feasibility of using wearable devices and self-reported technologies to identify symptom exacerbation correlates and relapse in patients with schizophrenia.

Methods
In this observational study, patients with schizophrenia were provided with remote sensing devices to continuously monitor activity (Garmin vivofit) and sleep (Philips Actiwatch), and smartphones were used to record patient-reported outcomes. Clinical assessments of symptoms (Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale) were performed biweekly, and other clinical scales on symptoms (Clinical Global Impression-Schizophrenia, Calgary Depression Scale), psychosocial functioning, physical activity (Yale Physical Activity Survey), and sleep (Pittsburgh Sleep Quality Index) were assessed every 4 weeks. Patients were observed for 4 months, and correlations between clinical assessments and aggregated device metrics data were assessed using a mixed-effect model. An elastic net model was used to predict the clinical symptoms based on the device features.

Results
Of the 40 patients enrolled, 1 patient relapsed after being stable with evaluable postbaseline data. Weekly patient-reported outcomes were moderately correlated with psychiatric symptoms (Brief Psychiatric Rating Scale total score, r=0.29; Calgary Depression Scale total score, r=0.37; and Positive and Negative Syndrome Scale total score, r=0.3). In the elastic net model, sleep and activity features derived from Philips Actigraph and Garmin vivofit were predictive of the sitting index of the Yale Physical Activity Survey and sleep duration component of the Pittsburgh Sleep Quality Index. On the basis of the combined patient data, a high percentage of data coverage and compliance (>80%) was observed for each device.

Conclusions
This study demonstrated that wearable devices and smartphones could be effectively deployed and potentially used to monitor patients with schizophrenia. Furthermore, metrics-based prediction models can assist in detecting earlier signs of symptom changes. The operational learnings from this study may provide insights to conduct future studies.

Trial Registration
ClinicalTrials.gov NCT02224430; https://www.clinicaltrials.gov/ct2/show/NCT02224430
An Evaluation of the Efficacy of LED Light Curing Units in Primary and Secondary Dental Settings in the United Kingdom
Authors: Altaie A , Hadis MA , Wilson V , German MJ , Nattress BR , Wood D , Palin WM 
Published: August 2021

SUMMARY

Objective:
This study aimed to evaluate the irradiance and the quality of LED light curing units (LCUs) in primary and secondary clinics in the UK and to assess the effect of damage, contamination, use of protective sleeves, and distance of light tips to target on the irradiance and performance of LCUs.

Methods:
The irradiance levels (mW/cm2) of 26 LED LCUs from general dental practices and 207 LED LCUs from two dental hospitals were measured using a digital radiometer (Blue Phase II, Ivoclar, Vivadent, Amherst, NY). Ten LED light guide tips (Satelec Mini, Acteon, Merignac, France) were selected to evaluate the effect of chipping, contamination (tip debris), and use of protective sleeves and tips to sensor distance on irradiance (mW/cm2) using a MARC Resin Calibrator (Blue Light Analytics, Halifax, Canada). Homogeneity of the light output was evaluated using a laser beam profiler (SP620; Ophir-Spiricon, North Longan, UT, USA). Statistical analysis was conducted using a one-way analysis of variance (ANOVA) with post hoc Tukey test (α=0.05) and linear regression with stepwise correlation tests.

Results:
Thirty-three percent of the LCUs delivered irradiance output less than 500 mW/cm2. The condition of the light curing tips was poor, with 16% contaminated with resin debris, 26% damaged, and 10% both contaminated and damaged. The irradiance output was significantly reduced in contaminated (62%) and chipped (50%) light curing tips and when using protective sleeves (24%) (p&lt;0.05). Irradiance was also reduced when increasing the distance with 25% and 34% reduction at 7 mm and 10 mm, respectively (p&lt;0.05).

Conclusion:
There remains a lack of awareness of the need for regular monitoring and maintenance of dental LCUs. Damaged and contaminated light curing tips, use of protective sleeves, and increasing the distance from the restoration significantly reduced the irradiance output and the performance of the LCUs.
INTERRELATIONS BETWEEN THE LINEAR AND NONLINEAR CHARAC TERISTICS OF SOILS ACC ORDING TO INSTRUMENTAL DATA
Authors: Заалишвили В.Б. 
Published: August 2021

В работе приведены корреляционные взаимосвязи между линейными и нелинейными характеристи- ками грунтов, установленные по данным записей колебаний различных грунтов, зарегистрированных при сильном Рачинском землетрясении 1991 года (Грузия) и результатам специальных исследований. Рассмотрен физический смысл введенного автором показателя, тесно связанного с поглощением и физической нелинейностью грунтов в виде площади подспектральной области нормализованного и реального спектров колебаний грунтов. Установлено соответствие особенностей изменения показателей динамического поведения грунтов (динамической жесткости грунта) и площади нормализованного и ре- ального спектра грунтовых колебаний. Показано, что в зависимости от уровня воздействия и прочности грунтов вполне отчетливо проявля- ется и может быть произведена относительная количественная оценка степени нелинейности и неупруго- сти грунтов. Это позволило получить эмпирические соотношения для надежной и физически обоснован- ной дифференциации грунтов по их сейсмическим свойствам
In the work the correlation interrelations between the linear and nonlinear characteristics of soils, established according to the data of the records of the fluctuations of different soils, registered with strong Rachinskiy earthquake of 1991 (Georgia) and to the results of special studies is given. Is examined the physical sense of the introduced by the author index, closely related to the absorption and the physical nonlinearity of the soils in the form of the area of the under spectra region of the normalized and real oscillation spectra of soils. The correspondence of the special features of a change in the indices of the dynamic behavior of soils (dynamic hardness of soil) and area of the normalized and real spectrum of ground of fluctuations is established. It is shown that depending on the level of action and strength of soils the relative quantitative assessment of the degree of nonlinearity and inelasticity of soils completely distinctly is manifested and can be produced. This made it possible to obtain empirical relationships for the reliable and physically substantiated differentiation of soils according to their seismic properties
THE RUSSIAN POLAR EXPEDITION (1901–1902): MATERIALS FROM THE ARCHIVE OF THE ORE AND PETROGRAPHIC MUSEUM AT IGEM RAS (INSTITUTE OF GEOLOGY OF ORE DEPOSITS OF THE RUSSIAN ACADEMY OF SCIENCES) AND THE LIBRARY COLLECTION OF GEOLOGICAL LITERATURE AT LNS RAS (THE LIBRARY ON NATURAL SCIENCE OF THE RUSSIAN ACADEMY OF SCIENCES). PART 3. THE RUSSIAN POLAR EXPEDITION (1901-1902): IN SEARCH OF SANNIKOV LAND
Authors: Докучаев А.Я. , Крехан Г.Р. , Каргин А.В. , Кулаков Ф.В. , Курдюков Е.Б. , Лексин А.Б. , Лобанов К.В. , Полякова М.В. , Юткина Е.В. 
Published: August 2021

История Русской Полярной экспедиции (РПЭ, 1900–1902 гг.) под руководством Эдуарда
Васильевича Толля, которая должна была найти землю Санникова и достичь Берингова пролива,
активно обсуждается в научной и популярной литературе.
В статье на основе официальных протоколов Императорской Академии наук, писем и дневников
ее участников, Э.В. Толля, А.В. Колчака, Ф.А. Матисена, А.А. Бялыницкого-Бирули рассмотрены по-
ставленные перед РПЭ задачи и достигнутые ей основные результаты. РПЭ сыграла важную роль в
освоении Северного морского пути и в организации последовавших за ней выдающихся российских и
советских арктических и полярных экспедиций.
The history of the Russian Polar Expedition (RPE, 1900-1902), that was headed by Edward V.
Toll and was supposed to fi nd the Sannikov Land and to reach the Bering Strait, is being actively discussed
in popular scientifi c literature.
Based on offi cial reports of the Russian Imperial Academy of Sciences, the expedition members’
correspondence and diaries (E.V. Toll, A.V. Kolchak, F.A. Mattisen, A.A. Bialynicki-Birula), the paper
discuses the tasks assigned to the expedition and its principal results achieved. The RPE played an
important role in the development of the Northern Sea Route and in organization subsequent signifi cant
Russian and Soviet Arctic and polar expeditions.
GLACIERS AND NEAR GLACIERS LAKES OF GULARIDON BASIN’S RIVER, CENTRAL CAUCASUS MOUNTAINS
Authors: Тавасиев Р.А. 
Published: August 2021

В статье приводятся новые данные по ледникам и приледниковым озерам, расположенным в бассейне реки Гуларидон (правый приток р. Караугом дон, левый приток р. Терек) и изменениях, произошедших на них за последние 52 года. Дан прогноз возможных опасных природных процессов, которые могут здесь произойти.
New data on the glaciers and near glaciers lakes located in the basin of river Gularidon (the right in ow of the Karaugomdon River, the lefthand in ow of the Terek River) and the changes, which happened on them for the last 52 years, are provided in article. The forecast of possible natural hazards, which can happen here, is given.
PENGARUH PEMBERIAN JINTAN HITAM (Nigella sativa) TERHADAP KADAR HDL (HIGH DENSITY LIPOPROTEIN) DAN LDL (LOW DENSITY LIPOPROTEIN) PADA BROILER JANTAN
Authors: Syahroni Syahroni , Santosa Purnama Edy , Siswanto Siswanto , Hartono Madi 
Published: August 2021

These study aimed to determine the effectiveness of Nigella sativa in increasing HDL levels and reducing LDL levels in male broilers. This research was conducted in December 2019 - January 2020 at the Integrated Field Laboratory, Faculty of Agriculture, University of Lampung. Analysis of HDL and LDL levels was carried out in Pramitra Biolab Indonesia. The study used sixty blood samples of Cobb male broiler. This study used a completely randomized design (CRD) with four treatments and each treatment was repeated three times, namely drinking water without a mixture of Nigella sativa (P0), drinking water with 36 mg/kg body weight=BW/day Nigella sativa (P1), drinking water with 72 mg/kg BW/day Nigella sativa (P2), drinking water with 144 mg/kg BW/day Nigella sativa (P3). Based on descriptive analysis that has been done Nigella sativa was effective in increasing HDL levels and reducing LDL levels in male broilers. Giving Nigella sativa with dose of 72 mg/kg BW/day resulted in the highest HDL levels of 88.6 mg/dl, whereas administration of Nigella sativa with dose of 144 mg/kg BW/day resulted in the lowest LDL level of 31.3 mg/dl.
Keywords: HDL LDL, Male broiler chickens, Nigella sativa
PENERAPAN MODEL PEMBELAJARAN PROJECT BASED LEARNING (PJBL) TERHADAP PEMAHAMAN KONSEP SISWA PADA MATERI SUHU DAN KALOR
Authors: Sonia Sonia , Kurniawan Yudi , Muliyani Riski 
Published: August 2021

Penelitian ini bertujuan untuk mendapatkan gambaran mengenai peningkatan aspek pemahaman konsep siswa setelah diterapkan model pembelajaran Project Based Learning (PjBL) pada materi suhu dan kalor. Penelitian menggunakan metode weak-experiment design dengan desain penelitian one group pretest-posttest design. Populasi penelitian adalah seluruh siswa kelas VII disalah satu MTS Singkawang dengan teknik pengambilan sampel berupa teknik cluster sampling. Penelitian dilakukan di kelas VII H yang berjumlah 23 orang siswa. Instrumen yang digunakan berupa tes pemahaman konsep objektif 18 pilihan ganda. Penelitian ini menemukan bahwa pemahaman konsep siswa mengalami peningkatan disemua aspek. Peningkatan nilai tertinggi terdapat pada aspek pemahaman konsep menafsirkan yang nilai N-gain-nya sebesar 0,7 dengan kategori tinggi. Pada aspek mencontohkan sebesar 0,5 dengan kategori sedang, aspek mengklasifikasikan sebesar 0,4 dengan kategori sedang, aspek menyimpulkan sebesar 0,6 dengan kategori sedang, aspek membandingkan sebesar 0,3 dengan kategori sedang, dan nilai terendah terdapat pada aspek menjelaskan yang nilai N-gain-nya sebesar 0,2 dengan kategori rendah. Dengan demikian, model pembelajaran Project Based Learning (PjBL) dapat dijadikan sebagai alternatif dalam meningkatkan kemampuan pemahaman konsep siswa pada materi suhu dan kalor.
ANTESEDEN KEPUASAN KERJA DAN PENGARUHNYA TERHADAP KINERJA APARATUR BADAN NARKOTIKA NASIONAL PROVINSI ACEH
Authors: Nasir Mohammad , Marbawi Marbawi , Qamarius Ibrahim 
Published: August 2021

This study aims to determine two antecedent variabels of job satisfaction and the impact on personil performance of National Narcotics Agency Aceh Province. The data used is the data by distributing questionnaires to 175 respondent of personil National Narcotics Agency Aceh Province. To analyze the data, the statistical analysis used structure equation modeling (SEM) and processed with the help of the application Amos. The variables measured include individual characterstic and work characteristic effect toward job satisfaction and then analysis of statistical test is individual characterstic, work characteristic and job satisfaction effect toward of Personil Performance of National Narcotics Agency Aceh Province. The result job satisfaction variable effect of partial mediated on individual characterstic and work characteristic toward to Personil Performance of National Narcotics Agency Aceh Province.
Rancang Bangun Aplikasi Presensi Menggunakan SmartCard RFID Berbasis Web
Authors: Tukadi Tukadi 
Published: August 2021

Presensi karyawan di dalam suatu perusahaan merupakan keperluan administrasi yang penting, karena dapat mempengaruhi besarnya gaji atau honor seorang karyawan dan juga dapat meningkatkan produktivitas perusahaan. Untuk itu dalam presensi diperlukan ketelitian agar tidak merugikan perusahaaan atau karyawan itu sendiri. Maka dari itu pada penelitian ini di ancang aplikasi presensi unntuk penggajian menggunakan Smart Card Rfid Berbasis Web. RFID ini sendiri memiliki kelebihan kecepatan baca data dibandingkan alat sejenisnya, selain itu RFID juga lebih murah dari segi harga dan juga pembacaan informasi lebih mudah karena bentuk dan bidang tidak mempengaruhi pembacaan informasi. Secara fungsional RFID terdiri 2 bagian inti yaitu RFID reader dan tag RFID. Tag RFID adalah komponen kecil yang menyimpan sebuah informasi rahasia dimana informasi tersebut hanya dapat dibaca menggunakan RFID reader. Dengan menggunakan Smart Card Rfid berbasis Web dihasilkan proses presensi bisa lebih teliti, akurat dan dapat dimonitoring secara realtime dengan menggunakan web, sehingga dari pihak karyawan ataupun perusahaan dapat memantau presensi dimanapun secara realtime. Agar sistem berjalan dengan baik diperlukan efisiensi pengiriman data, semakin ringan data yang dikirim maka throughtput yang dibutuhkan semakin kecil, dari hasil pengujian didapatkan prosentase keberhasilan 95%. Berdasarkan pengujian error rate yang mana dilakukan percobaan sebanyak 10 kali dapat diketahui bahwa 9 dari 10 data berhasil terkirim dengan baik. Agar tindakan ini tidak membuat sistem menunggu terlalu lama pengiriman data dibatasi dengan waktu 5 detik
Perancangan Sistem Pendingin Stayrofoam Air Conditionerportable Menggunakan Thermoelectric Cooler (Elemen Peltier)
Authors: Imaduddin Ilmi Rizki 
Published: August 2021

Abstrak— Pada penelitian ini dihasilkan perancangan dan sistem pendingin ruangan, hasil pengujian akurasi (thermoelektrik cooler, dan hygrometer). Pada hasil pengujian thermoelektrik cooler hasil rata-rata peltier didapatkan suhu 8,5 oC, peltier kedua didapatkan rata-rata 8,6 oC, peltier ketiga didapatkan rata-rata 5 oC, peltier ke empat didapatkan rata-rata 4,8 oC, peltier kelima didpatkan rata-rata 4,6 oC, dan peltier terakhir didapatkan 4,1 oC. Dan untuk hasil pengujian menggunakan hygrometer pembacaan temperatur relatif antara sensor NTC dengan hygrometer linear dengan R2 0,8004, dimana R2 merupakan regresi dan dapat menunjukkan kelelitian pengukuran alat yang dibuat sebesar 80 %. Dari data-data yang telah dianalisa, secara umum sistem suhu pendingin ruangan styrofom menggunakan thermoelektrik cooler pada penelitian ini telah memenuhi syarat umum sebuah pengendali, dimana untuk variasi-variasi akan menghasilkan respon yang diinginkan dari sebauah sistem pendingin. Apabila ada gangguan dari luar dapat ditanggapi secara responsif dari sistem, dengan selalu berusaha mendekatkan suhu sesuai set point.