bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-Related Quality of Life With Trastuzumab Monotherapy Versus Trastuzumab Plus Standard Chemotherapy as Adjuvant Therapy in Older Patients With HER2-Positive Breast Cancer
Authors: Taira Naruto , Sawaki Masataka , Uemura Yukari , Saito Tsuyoshi , Baba Shinichi , Kobayashi Kokoro , Kawashima Hiroaki , Tsuneizumi Michiko , Sagawa Noriko , Bando Hiroko , Takahashi Masato , Yamaguchi Miki , Takashima Tsutomu , Nakayama Takahiro , Kashiwaba Masahiro , Mizuno Toshiro , Yamamoto Yutaka , Iwata Hiroji , Ohashi Yasuo , Mukai Hirofumi , Kawahara Takuya ,   for the RESPECT Study Group
Published: April 2021

PURPOSE We report findings on quality of life (QoL) in the RESPECT trial, which compared adjuvant trastuzumab monotherapy with trastuzumab plus chemotherapy in older patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). PATIENTS AND METHODS Patients age 70-80 years with human epidermal growth factor receptor 2-positive surgically treated breast cancer were randomly assigned to receive trastuzumab (T) or trastuzumab plus chemotherapy (T + C). QoL was assessed using the Functional Assessment of Cancer Therapy-General (FACT-G), Philadelphia Geriatric Center Morale Scale, Hospital Anxiety and Depression Scale, Patient Neurotoxicity Questionnaire, and Tokyo Metropolitan Institute of Gerontology Index of Competence at baseline and after 2, 12, and 36 months. Comparisons were based on individual changes from baseline and were performed by Fisher’s test or mixed-model repeated-measures. RESULTS Among 275 patients in the parent study, 231 (84%) (average age: 74 years) were included in the analysis. At 2, 12, and 36 months, 198, 177, and 178 patients completed surveys, and the mean FACT-G scores at each survey point were 78.9, 80.4, 82.7, and 79.1 in group T and 79.5, 74.5, 78.4, and 78.5 in group T + C. Compared with group T + C, the proportion of patients showing QoL deterioration (≥ 5 points decrease from baseline in FACT-G) was significantly lower at 2 months (31% v 48%; P = .016) and 12 months (19% v 38%; P = .009). In group T, the Hospital Anxiety and Depression Scale score ( P = .003) and the proportion of severe sensory peripheral neuropathy ( P = .001) were significantly lower at 2 months, and Philadelphia Geriatric Center Morale Scale and Tokyo Metropolitan Institute of Gerontology Index of Competence scores were significantly higher ( P = .024, .042) at 12 months. At 36 months, there were no significant differences in any QoL items. CONCLUSION Detrimental effects of adjuvant chemotherapy on global QoL, morale, and activity capacity lasted for at least 12 months but were not observed at 36 months.
Gene Expression ofTakifugu rubripesGonads During AI- or MT-induced Masculinization and E2-induced Feminization
Authors: Yan Hongwei , Shen Xufang , Jiang Jieming , Zhang Lei , Yuan Zhen , Wu Yumeng , Liu Qi , Liu Ying 
Published: April 2021

AbstractElucidating the global molecular changes that occur during aromatase inhibitor (AI)– or 17α-methyltestosterone (MT)–induced masculinization and estradiol-17β (E2)–induced feminization is critical to understanding the roles that endocrine and genetic factors play in regulating the process of sex differentiation in fish. Here, fugu larvae were treated with AI (letrozole), MT, or E2 from 25 to 80 days after hatching (dah), and gonadal transcriptomic analysis at 80 dah was performed. The expression of dmrt1, gsdf, foxl2, and other key genes (star, hsd3b1, cyp11c1, cyp19a1a, etc.) involved in the steroid hormone biosynthesis pathway were found be altered. The expression of dmrt1, gsdf, cyp19a1a, and foxl2 was further verified by quantitative polymerase chain reaction. In the control group, the expression of dmrt1 and gsdf was significantly higher in XY larvae than in XX larvae, while the expression of foxl2 and cyp19a1a was significantly higher in XX larvae than in XY larvae (P &lt; .05). AI treatment suppressed the expression of foxl2 and cyp19a1a, and induced the expression of dmrt1 and gsdf in XX larvae. MT treatment suppressed the expression of foxl2, cyp19a1a, dmrt1, and gsdf in XX larvae. E2 treatment suppressed the expression of dmrt1 and gsdf, but did not restore the expression of foxl2 and cyp19a1a in XY larvae. The shared response following AI, MT, and E2 treatment suggested that these genes are essential for sex differentiation. This finding offers some insight into AI or MT-induced masculinization, and E2-induced femininization in fugu.
Determinants of dietary diversity practice among pregnant women attending antenatal clinic at Wachemo University Nigist Eleni Mohammed memorial referral hospital, Southern Ethiopia
Authors: Delil Romedan , Zinab Beakal , Mosa Hassen , Ahmed Ritbano , Hassen Habtamu 
Published: April 2021

BackgroundDietary diversity has continued to receive a global attention among pregnant women as they have been considered susceptible to malnutrition because of their increased nutrient demands. Thus, a variety of foodstuffs in their diet are necessary for ensuring the appropriateness of their nutrient consumptions. This study, therefore assessed the dietary diversity practice and its determinants among pregnant women attending antenatal clinic at Wachemo University Nigist Eleni Mohammed memorial referral hospital, Southern Ethiopia.MethodsA hospital-based cross-sectional study was carried out on 303 participants from May 1 to June 15, 2019 using a systematic random sampling technique. Data were entered and analyzed using SPSS (version24.0). Both bivariate and multivariable logistic regression analyses were used to decide the association of each explanatory variable with the outcome variable. Odds ratio with their 95% confidence intervals was calculated to identify the presence and strength of association, and statistical significance was declared atp< 0.05.ResultsThe overall prevalence of adequate dietary diversity practices was observed to be 42.6%. The determinants of dietary diversity practice included earning of a monthly income ≥2000 Ethiopian birr (AOR = 1.62; 95%CI:1.19–2.85), maternal educational level (AOR = 2.50; 95% CI: 1.05–6.12), educational status of partner (AOR = 2.45; 95% CI:1.20, 9.57), having a partner who was a government employee (AOR = 4; 95% CI:2.18–7.21), and the receiving of nutritional information (AOR = 1.35; 95% CI: 3.39–6.94).ConclusionsThe study indicated that the overall consumption of adequate dietary diversity practice was found to be low. Therefore, increasing household income, enhancing nutritional related information, advancing the academic level of both wife and her partner is essential to improve women’s dietary diversity practice.
Editorial
Authors: Seneda Marcos César 
Published: April 2021

[...]
O presente número, ora disponibilizado para os leitores, compõe-se de um dossiê temático, Reinscrever o conhecimento escolar no território do comum: uma introdução, o qual abriga seis artigos e uma entrevista, e inteira-se com mais oito artigos publicados sobre a temática de Educação e Filosofia, oriundos de diferentes pesquisas em ambas as áreas do conhecimento.
O dossiê refere-se ao domínio dos estudos curriculares e apresenta, através dos textos propostos, uma análise interdisciplinar sobre as diretrizes da concepção do saber escolar. Essa discussão é legitimada no contexto brasileiro atual em face das recentes discussões acerca das modificações empreendidas na Base Nacional Comum Curricular (BNCC). Procura-se aqui discutir a integração entre formação humana e as políticas orientadoras do ensino no país. Participam do dossiê pesquisadores de diferentes instituições de ensino superior brasileiras e estrangeiras. O dossiê ainda apresenta uma entrevista com a professora Elizabeth Fernandes de Macedo, com o propósito de oferecer aos leitores, juntamente com o registro da sua produção acadêmica, a crítica empreendida pela pesquisadora sobre a questão dos estudos curriculares e sobre o problema do conhecimento.
[...]
Recatolizar a Nação: Intelectuais Católicos na Comissão Nacional do Livro Didático (1938-1969)
Authors: Silva Aldemir Barbosa da , Carminati Celso João 
Published: April 2021

Recatolizar a Nação: Intelectuais Católicos na Comissão Nacional do Livro Didático (1938-1969)
Resumo: Este artigo analisa a presença de intelectuais católicos entre os membros da Comissão Nacional do Livro Didático (CNLD) como indício da relação de poder entre a Igreja Católica e o governo. Tal posição estratégica permite examinar, estimular, indicar e promover os livros didáticos na formação da nação, como aproximar a cultura católica dos princípios nacionalistas. Na primeira parte, apresentam-se sinais do movimento Reação Católica em torno do projeto de recatolizar a nação; na segunda, mostra-se a importância da CNLD entre os aparatos estatais em consonância com o projeto da construção institucional do governo; e, por fim, na terceira parte, indica-se a posição estratégica de intelectuais católicos na CNLD.
Palavras-chave: História da educação. Intelectuais católicos. Livro didático. Reação católica.
Recatolizing the Nation: Intellectual Catholics in the National Commission of the Didactic Book (1938-1969)
Abstract: This article analyzes the presence of Catholic intellectuals among the members of the National Textbook Commission (CNLD) as an indication of the power relationship between the Catholic Church and the government. Such a strategic position allows us to examine, stimulate, indicate and promote didactic books in the formation of the nation, how to bring Catholic culture closer to nationalist principles. In the first part, there are signs of the Catholic Reaction movement around the project to re-nation the nation; the second shows the importance of the CNLD among state apparatus in line with the government's institutional construction project; and, finally, in the third part, the strategic position of Catholic intellectuals in the CNLD is indicated.
Keywords: History of education. Catholic intellectuals. Textbook. Catholic reaction.
Recatolizar la Nación: Intelectuales Católicos en la Comisión Nacional del libro Didáctico (1938-1969)
Resumen: Este artículo analiza la presencia de intelectuales católicos entre los miembros de la Comisión Nacional del Libro Didáctico (CNLD) como indicio de la relación de poder entre la Iglesia Católica y el gobierno. Tal posición estratégica permite examinar, estimular, indicar y promover los libros didácticos en la formación de la nación, como aproximar la cultura católica de los principios nacionalistas. En la primera parte, se presentan señales del movimiento Reacción Católica en torno al proyecto de recatolizar la nación; en la segunda, se muestra la importancia de la CNLD entre los aparatos estatales en consonancia con el proyecto de la construcción institucional del gobierno; y, finalmente, en la tercera parte, se indica la posición estratégica de intelectuales católicos en la CNLD.
Palabras clave: Historia de la educación. Intelectuales católicos. Libro didáctico. Reacción católica.
Data de registro: 08/02/2019
Data de aceite: 02/03/2020
Financiamento: CAPES
La domanda sul l’uomo e la II Meditazione
Authors: Agostini Igor 
Published: April 2021

A questão sobre o homem e a II Meditação
Resumo: Neste artigo, analiso a noção pré-filosófica de “homem” discutida por Descartes na Segunda Meditação. Apesar da atenção dirigida a esse tópico pelos contemporâneos de Descartes, em particular Bourdin, os pesquisadores não se demoram sobre tal questão. Argumentarei nas páginas seguintes que a análise da noção pré-filosófica de homem, por parte de Descartes, constitui um caso paradigmático do procedimento seguido na Segunda Meditação para encontrar a distinção. Esse procedimento consiste, de fato, em um movimento que, retomando uma noção pré-filosófica, encontra, através da atenção e, por conseguinte, da clareza, a distinção: concentrando a atenção na noção pré-filosófica de homem em que “descobre” a cogitatio, o meditador torna tal noção clara; depois, a separa das determinações às quais está unida, tornando-a distinta.
Palavras-chave: Descartes; Meditações; Homem; Clareza e distinção.
La domanda sul l’uomo e la II Meditazione
Riassunto: In questo articolo analizzo la nozione pre-filosofica di ‘uomo discussa da Descartes nella Seconda Meditazione. A dispetto dell’attenzione rivolta su questo punto dai contemporanei di Descartes, in particolare Bourdin, gli studiosi non si sono particolarmente soffermati su tale questione. Argomenterò nelle pagine seguenti che l’analisi, da parte di Descartes, della nozione pre-filosofica di uomo costituisce un caso paradigmaico della procedura seguita nella seconda Meditazione per giungere alla distinzione. Questa procedura consiste, infatti, in un movimento che, regredendo da una nozione pre-filosofica, giunge, attraverso l’attenzione e, quindi, la chiarezza, alla distinzione: dentro la nozione pre-filosofica di uomo in cui il meditante ‘scopre’ la cogitatio, egli sofferma l’attenzione rendendo tale nozione chiara, poi la separa dalle determinazioni cui è unita nella medesima nozione rendendola distinta.
Parole-chiave: Descartes; Meditações; Homem; Clareza e distinção.
The question about man and II Meditation
Abstract: In this paper I will focus on the pre-philosophical notion of ‘man’ discussed by Descartes in the Second Meditation. In spite of the attention addressed on this very point by Descartes’s contemporaries, especially by Bourdin, scholars have not much dealt with this topic. In what follows, I will argue that Descartes’s analysis of the pre-philosophical notion of ‘man’ constitutes a paradigmatic case of the procedure followed in the Second Meditation in order to attain distinction. This procedure consists in a movement by which the meditator, by regressing from a pre-philosophical notion, obtains clearness through attention, and therefore distinctness through clearness: by focusing his attention on the pre-philosophical notion of ‘man’, in which he discovers the ‘cogitatio’, the meditator makes such a notion clear; then, by internal means of separation, he makes this notion distinct as well.
Keywords: Descartes; Meditações; Homem; Clareza e distinção.
Le feedback est-il toujours motivant ? Les attitudes des bacheliers polonophones de classes bilingues envers la rétroaction corrective écrite
Authors: Lipińska Julia 
Published: April 2021

Feedback is one of the key tools used to regulate the process of learning. In order to be effective, it must provide the students with accurate information and guidelines concerning their work by not only showing them mistakes, but also pointing out what they already know and giving advice to help them improve their skills. Poorly executed feedback may damage the students’ motivation instead of reinforcing it. Thus, it is important to know how students perceive different feedback techniques and how they react to them. To answer these questions, we led a research among Polish bilingual high school students learning French. We asked them about their preferences concerning feedback and about its perceived influence on their motivation. The results show students prefer detailed comments which show them positive and negative aspects of their work, without harming their self-esteem, i.e. by giving feedback in front of their peers. Such practices, according to students, have a beneficial effect on their motivation.
Les apprenants prennent la parole : analyse des procedes de cohesion utilises dans le cadre d’une interview avec des locuteurs natifs
Authors: Valetopoulos Freiderikos 
Published: April 2021

The aim of this paper is to explore the strategies used by B1 learners of French as a Foreign Language to construct their discourse and achieve cohesion during an interview with native speakers. The results of this analysis will highlight the characteristics of the development of oral competences. According to the Common European Framework of Reference for Languages, B1 learners can communicate with some confidence on familiar routine and non-routine matters related to their interests and professional field. In an interview task, learners are able to take some initiatives but are very dependent on the interviewer in the interaction. Learners should also be able to use a prepared questionnaire to carry out a structured interview, with some spontaneous follow up questions. The corpus analysis indicated certain strategies expressing inter-sentential and inter-sequential cohesion, such as use of discourse markers (et, donc) or markers of agreement (d’accord).
Zastosowanie analizy konwersacyjnej w dydaktyce akademickiej
Authors: Nowicka Agnieszka 
Published: April 2021

The article discusses a case study focusing on the students’ task of analyzing expressing opinions in Polish and English TV discussions. The written observation task is performed as a final requirement to receive credit for the course of interaction analysis, during which the second-year students of applied linguistics are introduced to the basic methods of conversation analysis. I use document analysis of students’ discourse to distinguish the main tendencies in performing the task by the students.
The aim of the research presented in the paper is assessing the students’ ability to use conversation analysis in observing different ways of expressing opinion in selected Polish and American TV discussions. I especially focus on evaluating the students’ skill of unmotivated looking at the ways of expressing opinions in TV discussions. This phenomenological observation requires suspending the researcher’s personal views and assumptions concerning the meaning of actions in interaction. The main aim of conversation analysis is discovering the meaning of communicative actions from the perspective of a talk participant. If applied appropriately, this kind of observation allows student-researchers to avoid a tendency to rely on stereotypical evaluations in the analysis of interactions.
The effect of athletic training on strength in prepubertal children aged 6-9 years
Authors: Branet Camelia 
Published: April 2021

Abstract
The problem of practicing a sport during childhood is a largelycommented topic, being closely related to the physical development, physiological and emotional balance of the human body during the growth period.The obesity rate increased with over 20% in prepubertal children, which inevitably led to a decrease in their motor performance in strength, speed and endurance efforts, hence the imperative to train strength in children.Starting from this idea, our study aimed at investigating whether a 10-monthtraining program involving athletic means could improve strength inprepubertal children aged 6-9 years. There were 50investigatedsubjects aged 6-9 years, of whom 20subjectswere part of the experimental group. The athletics lessons took place three times per week and lasted 80 minutes.Strength was assessed by two motor tests: standing long jump and sit-ups from lying on the back within30 seconds. After the statistical processing of the obtained results in the two motor tests, we can conclude that, at this age, it is possible tointervene on the improvement of both the lower-limb explosive strength andthe abdominal muscle strength.
THE RISE OF INDIA IN THE NEW BALANCE OF POWER IN ASIA SINCE THE BEGINNING OF 21ST CENTURY: IMPACTS ON INDIA - VIETNAM RELATIONS
Authors: Nam Tien Tran 
Published: April 2021

Purpose of the study: The study focuses on the rise of India in the new balance of power in Asia since the beginning of the 21st century. It had three major purposes: (a) to discover the new balance of power in Asia (b), to examine the possible predicting scenario about the role of India in Asia’s order; (c) to understand critical influences of the Indian rise that affect on India-Vietnam relations.
Methodology: This study describes a qualitative study based upon a combination of three main methods such as historical method, analysis-synthesis method (documentary analysis), and case study method. The data were sourced from secondary data and content analysis in various publications of governments, foreign governments, or international bodies. Moreover, foreign policy journals, books, magazines, newspapers, and public records.
Main Findings: The study had some key research findings. The first main finding was that the rise of India would contribute to the common development of Asian countries and affirm the position of Asia on the world map. The second major finding was that India-Vietnam relationships supported India becoming a peaceful superpower dominating East Asia, especially Southeast Asia.
Applications of this study: The implications of the study can be supported by the observation of foreign policy substitutability. This study about the rise of India can be used to get the support of the policymaker or government to make the foreign policy adapting to the new era in Asia. Moreover, the study is also a valuable document for students majoring in International Relations, International History, and Politics.
Novelty/Originality of this study: There is no or has not been any study that discusses the rise of India in the new balance of power in Asia since the beginning of the 21st century and its impacts on India-Vietnam relations.
RETRATOS DA EJA NA AMAZÔNIA MARAJOARA: DESAFIOS DO ENSINO DA LÍNGUA INGLESA NA EDUCAÇÃO ESCOLAR QUILOMBOLA
Authors: Ribeiro Karley Dos Reis , Santos Raquel Amorim dos , Brito Camila De Cássia 
Published: April 2021

O presente estudo se propôs a discutir o ensino da Língua Inglesa (LI) para alunos da Educação de Jovens e Adultos (EJA), na perspectiva da Educação Escolar Quilombola (EEQ), em uma escola quilombola do município de Salvaterra da Amazônia Marajoara. A pesquisa analisou o ensino da LI e seus desdobramentos para a EEQ, permitindo evidenciar outras perspectivas para o ensino do idioma. Utilizou-se a análise interpretativista e pesquisa bibliográfica especializada da área. A pesquisa é de natureza qualitativa e de cunho interpretativista, e os aportes teóricos que embasaram a análise dos dados foram: Pennycook (1998), Rajagopalan (2003), Moita Lopes (2002; 2005), entre outros. Os resultados da pesquisa evidenciaram que as questões étnico-raciais nas aulas de LI na EJA da EEQ é um campo desafiador para alcançar a qualidade do ensino da LI na proposta da EEQ. A necessidade de formação continuada dos professores de LI para as relações étnico-raciais é uma necessidade emergencial, pois os dados indicaram que os desafios estão associados majoritariamente as práticas pedagógicas do professor de LI.
NARRATIVAS DE CRIANÇAS SOBRE O SABER/FAZER EM FESTAS AMAZÔNICAS: O CASO DA MARUJADA DE SÃO BENEDITO E SÃO SEBASTIÃO EM TRACUATEUA/PA
Authors: Silva Dilma Oliveira da , Carvalho Nazaré Cristina 
Published: April 2021

O estudo tem como objetivo analisar os saberes e os fazeres vivenciados pelas crianças durante a festa da marujada no município de Tracuateua/PA. A problemática fomentada norteou-se pela seguinte pergunta: qual a percepção das crianças da marujada de Tracuateua/PA sobre os saberes/fazeres dessa festividade? Para isso, foi necessário discutir as categorias cultura, educação, saberes e infância sobre novos olhares na perspectiva da cultura representada como “teia de significados” construídos nas relações sociais dos homens; a educação como uma “fração dessa cultura” e que pode ser desenvolvida em diferentes lugares com diversos grupos sociais; os saberes enquanto um aprendizado transmitido entre gerações numa heterogeneidade de fazer; a infância foi analisada à luz da “sociologia da infância”, compreendendo a criança como protagonista de suas vivências. Este estudo teve como intérpretes 16 (dezesseis) crianças, sendo 10 (dez) meninas e 6 (seis) meninos, com faixa etária entre 6 (seis) e 12 (doze) anos de idade, participantes da festa. O percurso metodológico foi caracterizado pela abordagem qualitativa com técnicas de pesquisa como rodas de conversas, observação, diários de campo, registros fotográficos e a dinâmica com desenhos. Dessa forma, partindo da diversidade de conhecimento construídos no cotidiano da marujada identificou-se saberes e fazeres inerentes a festa vivenciados e partilhados do/pelo movimento entre marujos e marujas de diferentes gerações por meio da escuta, da observação e da oralidade.