bluuebunny/crossref_metadata_2025_split huggingface dataset:
Berberine Attenuates Chronic Atrophic Gastritis Induced by MNNG and Its Potential Mechanism
Authors: Tong Yuling , Liu Liping , Wang Ruilin , Yang Tao , Wen Jianxia , Wei Shizhang , Jing Manyi , Zou Wenjun , Zhao Yanling 
Published: March 2021

The purpose of this study was to investigate the therapeutic effect of berberine (BBR) on MNNG-induced chronic atrophic gastritis (CAG) and the possible mechanism of BBR through TGF-β1/PI3K signal pathway. GES-1 were pretreated with MNNG for 2 h before BBR treatment in all procedures. Cell viability was quantified by cell counting kit-8, and GES-1 morphology and proliferation were detected by high content screening (HCS) assay. The rat model of CAG was established by MNNG, and the therapeutic effect of BBR on stomach histopathology and serum supernatant were analyzed in vivo. In addition, the possible mechanism of BBR was further discussed, and the expression of related genes and proteins in TGF-β1/PI3K signal pathway was detected. The results showed that BBR could significantly improve the survival rate and morphological changes of GES-1, improve the gastric tissue injury of CAG rats, and reduce the expression of G-17 and inflammatory factors IL-8, TNF-α, IL-6 and IL-1β. In addition, BBR down-regulated the expression of TGF-β1 axis-related signals such as TGF-β1, PI3K, p-Akt/Akt, p-mTOR/mTOR and P70S6K, and promoted the expression of PTEN, LC3-II and Beclin-1. In Conclusion, BBR can improve CAG which may be closely related to TGF-β1/PI3K signal pathway.
A Method for Multihole Blasting Seismic Wave Prediction and Its Application in Pillar Recovery
Authors: Xie Lianku , Xiong Daiyu , Yang Tianhong , He Li , Yu Qinglei 
Published: March 2021

Long-hole blasting in mines is likely to cause strong vibration of surficial infrastructure, greatly damage the rock mass surrounding goaf near explosion center, and possibly induce blast vibration disasters. In this article, an improved method for multihole blasting seismic wave prediction is proposed to estimate far-field blast vibration. In this method, the fundamental vibration waveforms are firstly measured through the field blast with a single deck at an underground pilot area. The fundamental vibration waveforms are then used to simulate the vibration waveforms for a single-deck case in the production blast by considering the difference of the equivalent distances from the production blast site and the pilot area to the surface measuring point. The vibration waveforms for the single-deck case are linearly superposed to predict the possible vibration waveforms in production blast with multiple long holes and decks according to the designed delay time between decks. Based on these predicted waveforms, the blast vibration can be estimated and the blast design can be optimized to determine a rational delay time in accordance with the vibration limit. The proposed method was applied in pillar recovery of Hongling Polymetallic Mine to optimize the long-hole blast design to manage blast vibration. The rational delay time for the 716 production blast design was recommended as 26 ms. The practice showed that the blast vibration induced by the 716 production blast has been managed, and the predicted and the measured waveforms agree well. It provides an effective method for multihole blast design to control blast vibration.
Irisin Regulating Skeletal Response to Endurance Exercise in Ovariectomized Mice by Promoting Akt/β-Catenin Pathway
Authors: Zhao Renqing , Zhou Yalan , Li Jinqiao , Lin Junjie , Cui Wei , Peng Yan , Bu Wenqian 
Published: March 2021

Purpose: Thought irisin is recognized as a pivotal modulator for bone formation, its role in regulating skeletal response to exercise training remains unknown. Therefore, we aimed to determine the change of irisin in response to 8-week exercise training and its role in regulating the effects of exercise on bone loss in ovariectomized (Ovx) mice.Methods: Forty 3-month old female C57BL/6 mic were randomly allocated into four groups: (1) Sham-operated (Sham); (2) ovariectomized; (3) Ovx plus 8-week downhill running exercise (Ex); (4) Ovx plus exercise and received twice weekly injection of cyclo RGDyk protein (a putative anti-irisin receptor agents) (ExRg).Results: Ex group showed enhanced cortical and trabecular volumetric bone mineral density (vBMD) (p &lt; 0.05), improved bone microarchitecture, and increased intensity of alkaline phosphatase positive (ALP+) cells compared with Ovx group. However, cyclo RGDyk administration weakened the exercise-related improvement of vBMD, BV/TV, and ALP intensity in bone. Serum estradiol, irisin, and bone alkaline phosphatase were higher, whereas circulating tartrate-resistant acid phosphatase was lower in Ex group compared with Ovx group (p &lt; 0.05). Exercise promoted mRNA expression of fibronectin type III domain-containing protein 5 (FNDC5), Akt and β-catenin, and enhanced protein levels of FNDC5, the ratio of phosphorylated Akt (p-Akt) to Akt, and β-catenin (p &lt; 0.05). When irisin pathways were blocked with cyclo RGDyk, increment of Akt, p-Akt/Akt, and β-catenin in Ex mice were attenuated.Conclusion: It is suggested that irisin plays a potential role in regulating skeletal response to exercise partly through its interaction with Akt/β-catenin pathways.
Combined Chair-Based Exercises Improve Functional Fitness, Mental Well-Being, Salivary Steroid Balance, and Anti-microbial Activity in Pre-frail Older Women
Authors: Furtado Guilherme Eustáquio , Letieri Rubens Vinícius , Silva-Caldo Adriana , Trombeta Joice C. S. , Monteiro Clara , Rodrigues Rafael Nogueira , Vieira-Pedrosa Ana , Barros Marcelo Paes , Cavaglieri Cláudia Regina , Hogervorst Eef , Teixeira Ana Maria , Ferreira José Pedro 
Published: March 2021

IntroductionRegular exercise has long been shown to positively impact the immune system responsiveness and improve mental well-being (MWB). However, the putative links between biomarkers of mental health and immune efficiency in exercising subjects have been scarcely investigated. The aim of this study was to verify the effect of a 14-week combined chair-based exercise program (CEP) on salivary steroid hormones and anti-microbial proteins, functional fitness, and MWB indexes in pre-frail older women.MethodsThe participant women (82.8 4.6 years old; n = 32) were randomly divided into the exercising group (CEP, n = 17) and the non-exercising control group (CG, n = 15). The pre/post assessment included: (1) salivary anti-microbial proteins lysozyme; (Lys) and immunoglobulin-A (IgA); (2) salivary steroid hormones of testosterone (TT) and cortisol (COR); (3) functional fitness (gait speed, hand grip strength, and static balance); (4) MWB questionnaires (happiness, depression state, satisfaction with life, and stress).ResultsSignificant differences with large Cohen’s (d) effect sizes were found on increased salivary TT (p &lt; 0.05; d = 0.60) after exercise intervention. The results revealed a decrease in IgA levels after CEP (p &lt; 0.01, d = 0.30). The increase in subjective happiness levels (p &lt; 0.05, d = 0.30) and decrease of stress perception (p &lt; 0.01, d = 2.60) and depressive state (p &lt; 0.05, d = 0.30) were found after intervention in the CEP group. Robust statistical differences in gait speed (p &lt; 0.05; d = 0.60) and balance tests (p &lt; 0.05; d = 0.80) were also found in the CEP group. In control, COR increased moderately (p &lt; 0.05; d = 0.65) while no changes were found for the other indicators. Correlation analyses showed inter-dependence between pre–post variations of MWB, biochemical indexes, and fitness function (e.g., COR inverse correlation with hand grip strength and balance tests).ConclusionThe CEP program was able to improve functional-fitness performance, decrease feelings of stress, and increase happiness. The CEP also induced clinically relevant hormonal and immune responses, which suggests that chair exercises that combine muscular strength, balance, and gait speed training are promising interventions to improve physical and mental health of older pre-frail adults.
Higher Negative Self-Reference Level in Patients With Personality Disorders and Suicide Attempt(s) History During Biological Treatment for Major Depressive Disorder: Clinical Implications
Authors: Bulteau Samuel , Péré Morgane , Blanchin Myriam , Poulet Emmanuel , Brunelin Jérôme , Sauvaget Anne , Sébille Véronique 
Published: March 2021

Objective: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depressive Disorder (MDD).Methods: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory (BDI13). Associations between depression changes on BDI13 domains (Negative Self-Reference, Sad Mood, and Performance Impairment), treatment arm, time, and clinical variables were tested in a mixed linear model.Results: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI13 were personality disorders (+2.1 points), a past history of suicide attempt(s) (+1.7 points), age under 65 years old (+1.5 points), and female sex (+1.1 points).Conclusions: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt(s).
The First-Night Effect in Elite Sports: An Initial Glance on Polysomnography in Home-Based Settings
Authors: Hof zum Berge Annika , Kellmann Michael , Jakowski Sarah 
Published: March 2021

Self-applied portable polysomnography is considered a promising tool to assess sleep architecture in field studies. However, no findings have been published regarding the appearance of a first-night effect within a sport-specific setting. Its absence, however, would allow for a single night sleep monitoring and hence minimize the burden on athletes while still obtaining the most important variables. For this reason, the aim of the study was to assess whether the effect appears in home-based sleep monitoring of elite athletes.The study sample included eight male and 12 female German elite athletes from five different sports. Participants slept with a portable polysomnography for two nights, which they self-applied at night before going to bed. Time in bed and wake-up time in the morning were freely chosen by each individual athlete without any restrictions regarding time or sleeping environment. Participants were asked to keep the same location and time frame during the two days of monitoring and stick to their usual sleeping schedules. Sleep stages were manually scored using 30-s epochs. Sleep parameters and stages were later compared with the help of linear mixed models to investigate the factor time.Significant differences between the two nights were found for percentage of Non-REM sleep [T(19) = −2,10, p &lt; 0.05, d = −0.47, 95%-CI (−7.23, −0.01)] with small effect size, Total Wake Time [T(19) = 2.30, p = 0.03, d = 0.51, 95%-CI (1.66, 35.17)], Sleep Efficiency [T(19) = −2.48, p = 0.02, d = −0.55, 95%-CI (−7.43, −0.63)], and Wake percentage [T(19) = 2.47, p = 0.02, d = 0.55, 95%-CI (0.61, 7.43)] with moderate effect sizes, and N3 Sleep Onset Latency [T(19) = 3.37, p &lt; 0.01, d = 0.75, 95%-CI (7.15, 30.54)] with large effect size. Confidence Intervals for all other indices range from negative to positive values and hence specify, that parameters were not systematically negatively affected in the first night.Findings suggest that some individuals are more affected by the first-night effect than others. Yet, in order to keep the measurement uncertainties to a minimum, a more conservative approach with at least two monitoring nights should be used whenever possible, if no other supporting information on the athletes says otherwise.
Disentangling Within- and Between-Person Effects During Response Inhibition in Obsessive-Compulsive Disorder
Authors: Hagland Pernille , Thorsen Anders Lillevik , Ousdal Olga Therese , Gjestad Rolf , de Wit Stella J. , Hansen Bjarne , Hagen Kristen , Kvale Gerd , van den Heuvel Odile A. 
Published: March 2021

Background: Obsessive-compulsive disorder (OCD) has been related to worse performance, abnormal brain activity, and functional connectivity during response inhibition. Whether these findings are indications of stable traits that contribute to the development of the disorder, or whether they are a result of the state severity of obsessions and anxiety, remains unclear since previous research mainly has employed cross-sectional designs. The present study aimed to assess longitudinal between- and within-person relationships between symptoms, task performance, right inferior frontal gyrus brain activation, and connectivity between the right amygdala and the right pre-supplementary motor area in 29 OCD patients before and after concentrated exposure and response prevention treatment.Method: Patients received exposure and response prevention delivered during 4 consecutive days, following the Bergen 4-day Treatment format. Patients performed a Stop Signal Task during 3T functional Magnetic Resonance Imaging the day before treatment, as well as 1 week and 3 months after treatment completion. Multilevel models were used to analyze disaggregated within- and between-person effects over time. Independent variables were scores on the symptom severity scales for OCD, anxiety, depression, and state distress during scanning. Dependent variables were reaction time for go trials, stop signal response time, task-related brain activation and connectivity.Results: A positive between-person effect was found for obsessive-compulsive, anxiety, and depressive symptom severity on go trial reaction time, indicating that patients with higher symptom scores on average respond slower during accurate go trials. We also found no significant between- or within-person relations between symptom severity and task-related activation or fronto-limbic connectivity.Conclusions: The between-person findings may point toward a general association between slower processing speed and symptom severity in OCD. Longitudinal studies should disaggregate between- and within-person effects to better understand variation over time.
Cortical Thickness Changes in Chronic Ketamine Users
Authors: Zhong Jun , Wu Huawang , Wu Fengchun , He Hongbo , Zhang Zhaohua , Huang Jiaxin , Cao Penghui , Fan Ni 
Published: March 2021

Background: Previous studies have examined the effects of long-term ketamine use on gray matter volume. But it is unclear whether chronic ketamine use alters cortical thickness and whether cortical thickness changes in chronic ketamine users are associated with cognitive deficits observed in chronic ketamine users.Methods: Here, 28 chronic ketamine users and 30 healthy controls (HCs) were recruited. Cortical morphometry based on Computational Anatomy Toolbox (CAT12) was used to measure cortical thickness. Cognitive performance was measured by MATRICS Consensus Cognitive Battery (MCCB). Two-sample t-test was used to assess differences in cortical thickness and cognitive performance between the two groups. Partial correlation analysis was used for assessing correlations between cortical thickness changes and clinical characteristics, cognitive performance in chronic ketamine users.Results: Chronic ketamine users exhibited significantly reduced cortical thickness in frontal, parietal, temporal, and occipital lobes compared to HC [false discovery rate (FDR) corrected at p &lt; 0.05]. In chronic ketamine users, the average quantity (g) of ketamine use/day was negatively correlated with cortical thickness in the left superior frontal gyrus (SFG), right caudal middle frontal gyrus (MFG), and right paracentral lobule. The frequency of ketamine use (days per week) was negatively correlated with cortical thickness in the left isthmus cingulate cortex. Duration of ketamine use (month) was negatively correlated with cortical thickness in the left precentral gyrus. The chronic ketamine users showed significantly poorer cognitive performance on the working memory (P = 0.009), visual learning (P = 0.009), speed of processing (P &lt; 0.000), and Matrics composite (P = 0.01). There was no correlation between scores of domains of MCCB and reduced cortical thickness.Conclusion: The present study observed reduced cortical thickness in multiple brain areas, especially in the prefrontal cortex (PFC) in chronic ketamine users. Dose, frequency, and duration of ketamine use was negatively correlated with cortical thickness of some brain areas. Our results suggest that chronic ketamine use may lead to a decrease of cortical thickness. But the present study did not observe any correlation between reduced cortical thickness and decreased cognitive performance in chronic ketamine users.
A Bioecosystem Theory of Negative Symptoms in Schizophrenia
Authors: Strauss Gregory P. 
Published: March 2021

Objective:Negative symptoms are a core feature of schizophrenia that has been linked to numerous poor clinical outcomes. Although person-level mechanisms have been identified for negative symptoms, psychosocial and pharmacological treatments targeting these mechanisms have been ineffective. The current theoretical paper proposes that limited treatment progress may result in part from a failure to identify and target environmental processes that cause and maintain negative symptoms.Methods:A novel theoretical model is outlined, called the bioecosystem theory of negative symptoms, that offers a conceptual framework for studying interactions among environmental systems and person-related biological and psychosocial factors.Results:Relying on Bronfenbrenner's developmental theory as an organizing framework, four interactive environmental systems are proposed to be critical for the genesis and maintenance of negative symptoms: (1) Microsystem: the immediate environment; (2) Mesosystem: the interactions among microsystems; (3) Exosystem: indirect environments that influence the individual through the microsystems; (4) Macrosystem: socio-cultural factors. The environmental factors within these systems are proposed to function as a network and have dynamic within-system interactions, as well as cross-system interactions that change over time and across phases of illness.Conclusions:Environmental contributions to negative symptoms have received minimal empirical attention, despite their potential to explain variance in negative symptom severity. The bioecosystem model of negative symptoms introduced here offers a novel conceptual framework for exploring environmental contributions to negative symptoms and their interaction with person-level biological and psychological factors. This theory may facilitate new avenues for identifying environmental treatment targets and novel systems-level interventions.
Social Determinants of Health and Well-Being of Adolescents in Multicultural Families in South Korea: Social-Cultural and Community Influence
Authors: Shin Jungeun , Lee Hyeonkyeong , Choi Eun Kyoung , Nam Chungmo , Chae Sun-Mi , Park Oksik 
Published: March 2021

Objectives: Adolescents in multicultural families (AMFs) are exposed to numerous stressors and face environmental vulnerability within the family, school, and community systems, which may affect their health and well-being. Concrete discussion on policies is lacking due to insufficient data on the levels of well-being of AMFs in South Korea. This study aimed to investigate social-cultural and community factors affecting their well-being.Methods: A cross-sectional study was conducted with a convenience sample of 206 AMFs (aged 13–18 years) from 16 general schools and three multicultural schools across eight large cities. AMFs completed a self-administrative questionnaire assessing well-being, individual factors (acculturative stress, health behavior), social and community factors (social support, sense of community), and environmental factors (school type, economic status). Data were analyzed using structural equation modeling.Results: Social support and sense of community significantly and directly affected well-being. The economic status and type of school had an indirect effect on well-being, whereas the effect of acculturative stress was not significant. Factors significantly affecting adolescents' well-being were social support, sense of community, economic status, and type of school.Conclusion: Addressing well-being may be the strategy leading AMFs to grow into healthy adults. These results could help educators, health professionals, and policymakers to identify ways to enhance the well-being of AMFs.
PERAN BMT EL-MIZAN ANNAFII DALAM MENINGKATKAN KUALITAS USAHA MIKRO
Authors: Yudih Dadang , Sharah Cahya Muthia , Nursamsiah Mira 
Published: March 2021

ABSTRAKPenelitian ini bertujuan untuk menganalisa peran aktif koperasi syariah dalam meningkatkan kualitas usaha mikro dan mengetahui jenis-jenis peranan koperasi syariah dalam meningkatkan kualitas usaha mikro. Metode penelitiannya adalah metode kualitatif dengan pengambilan data melalui wawancara terstruktur, observasi lapangan dan dokumentasi. Hasil dari penelitian memperlihatkan bahwa BMT EL-MIZAN ANNAFII telah menjalankan perannya secara umum sebagai koperasi syariah yang mampu membuat kegiatan ekonomi dan sosial anggotanya yang merupakan warga sekitar masjid menjadi lebih baik dan sejahtera, sedangkan jenis-jenis peran aktif yang telah dilakukan oleh BMT EL-MIZAN ANNAFII dalam peningkatan kualitas usaha mikro hanya pada aspek fisik pemasaran produk (toko dan kerjasama dengan muslimah center) dan belum menyentuh aspek manajemen pemasaran jasa (kualitas pelayanan), manajemen produksi barang, manajemen keuangan, akuntansi sederhana, manajemen SDM dan etika bisnis syariah. ABSTRACTThis research aims to analyze the role of active Islamic cooperative in improving the quality of the micro enterprise and know the kinds of cooperative role of Sharia in improving quality of micro enterprises.Qualitative research methods are methods with data retrieval through structured interviews, field observations and documentation.The results of the research show that the BMT EL-MIZAN ANNAFII has run its role in General as a cooperative of Sharia that are able to make economic and social activities of its members which is the community around the mosque became a better and prosperous, while the types of initiatives that have been undertaken by the BMT EL-MIZAN ANNAFII in the improved quality of micro enterprises only on the physical aspects of the marketing of products and haven't touched aspects of marketing management services (quality of service), production management, financial management, simple accounting, human resource management and business ethics