bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of acclimation to elevated water temperature and hypoxia on thermal tolerance of the threatened pugnose shiner (Notropis anogenus)1
Authors: McDonnell Laura H. , Mandrak Nicholas E. , Kaur Saravpreet , Chapman Lauren J. 
Published: May 2021

For freshwater fishes, elevated water temperatures associated with climate warming and hypoxia can co-occur and are likely to interact as both affect oxidative metabolism. We quantified the effects of acclimation to elevated temperature and hypoxia on the thermal tolerance of pugnose shiner (Notropis anogenus), a cyprinid fish threatened in its Canadian range. In one experiment, pugnose shiner underwent two-week sequential acclimations to six increasing temperatures. Fish acclimated to warmer waters increased their critical thermal maximum (CTmax), while the agitation temperature (Tag) was 3.4 °C lower than the CTmax. In another experiment, fish were acclimated to three dissolved oxygen treatments (>95%, ∼56%, or ∼40% air saturation) for two weeks and tested under >95% and 40% conditions. CTmax was lower when measured under 40% for normoxia-acclimated fish but not for hypoxia-acclimated fish. Hypoxia-acclimated fish had higher Tag and smaller agitation windows than normoxia-acclimated fish, suggesting that hypoxia acclimation improves aspects of thermal tolerance. We examine the plasticity of thermal tolerance of pugnose shiner, showing that they may be more vulnerable to high temperatures compared with other non-imperiled Notropis species.
Optical and thermodynamic properties of a rotating dyonic black hole spacetime in $${\mathcal {N}} = 2, U(1)^2$$ gauged supergravity
Authors: Sharma Prateek , Nandan Hemwati , Papnoi Uma , Chatterjee Arindam Kumar 
Published: May 2021

AbstractThe null geodesics and the distance of closest approach for photon around a rotating dyonic black hole in $${\mathcal {N}} = 2, U(1)^2$$

N
=
2
,
U

(
1
)

2

gauged supergravity is studied. The phenomenon of black hole shadows with various black hole parameters has also analyzed. Further, the investigation of various thermodynamic properties for this black hole is performed with various thermodynamic parameters at the horizon. The heat capacity to study the thermodynamic stability of this black hole spacetime is also studied. The influence for different values of the black hole parameters $$ \nu $$
ν
, e, $$ \nu $$
ν
, g and $$N_{g}$$

N
g

on the phenomenon of black hole shadows and thermodynamic parameters is also investigated visually.
Changes in Macular Microvascular Structure in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Antivascular Endothelial Growth Factor for One Year
Authors: Song Shuang , Yu Xiaobing , Zhang Peng , Dai Hong 
Published: May 2021

Purpose. To observe the changes in macular microvascular structure and the correlation between anatomy and visual function in patients with macular edema secondary to branch retinal vein occlusion (BRVO) treated with antivascular endothelial growth factor for one year. Methods. This prospective study enrolled 39 patients (one eye per patient) who received intravitreal injections of ranibizumab for macular edema secondary to BRVO. All patients received a minimum of 3 initial monthly ranibizumab injections and criteria-driven pro re nata (PRN) dosing thereafter for visual acuity (VA) and central retinal thickness (CRT) stabilization. The follow-up period of this study was one year. The vascular density (VD) of the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP), the foveal avascular zone (FAZ) area, the FAZ perimeter, the VD within a 300 μm wide ring surrounding the FAZ (FD-300), and the acircularity index (AI) were measured automatically by optical coherence tomography angiography (OCTA) at baseline, month 6, and month 12. Results. Compared with those before treatment, the VD of the SCP significantly decreased 6 months after treatment (

P
<
0.05

), while the area and perimeter of the FAZ increased significantly (

P
<
0.01

). After 12 months of treatment, the area and perimeter of the FAZ increased significantly (

P
<
0.01

). There was no significant difference in any parameters between 12 months and 6 months after treatment (

P
>
0.05

). The change in BCVA was negatively correlated with the VD of the SCP at 12 months (

P
=
0.0447

, r = −0.3233). There was a relationship between the DBP and AI, and CRT was related to VD of DCP at baseline (

P
=
0.028
,

0.0209

; r = 0.383, −0.384). The PERIM and AI at 12 months were significantly associated with the recurrence of macular edema, and the changes in vascular density in the SCP and PERIM were significantly associated with the number of injections within 12 months (

P
<
0.05

). Conclusions. One year after ranibizumab treatment, the area and perimeter of the FAZ were enlarged, while the VD of the SCP and DCP remained stable, which indicated that ranibizumab treatment did not improve macular blood supply and macular ischemia in BRVO patients.
Influência do isomorfismo institucional na aceitação do orçamento mediada pelas finalidades de planejamento e diálogo
Authors: Luz Igor Pereira da , Lavarda Carlos Eduardo Facin 
Published: May 2021

O estudo teve como objetivo examinar a influência do isomorfismo institucional na aceitação do orçamento, mediada pelas finalidades do artefato. Realizou-se uma survey com gerentes das empresas do setor farmacêutico vinculadas ao Guia da Farmácia com amostra de 147 respostas válidas. Para a análise de dados e teste de hipóteses foi utilizada a Modelagem de Equações Estruturais pelos mínimos quadrados parciais. Os resultados apontam que os fatores coercitivos, miméticos e normativos advindos do ambiente levam a uma maior utilidade do artefato no contexto estudado. Aponta-se também para a influência positiva e significativa das finalidades de planejamento e a resposta estratégica de aceitação. O isomorfismo institucional ainda apresentou influência positiva e significativa na aceitação do orçamento. Encontrou-se ainda a mediação parcial das finalidades do orçamento na relação entre isomorfismo institucional e a resposta estratégica de aceitação. Infere-se que para uma maior aceitação faz-se relevante, além de utilizar o artefato para responder as pressões institucionais, dar utilidade às finalidades do orçamento nas atividades cotidianas da empresa. Como contribuições a teoria, o estudo reforça a complementaridade entre as proposições de isomorfismo institucional de DiMaggio e Powell (1983) e o modelo de respostas estratégicas propostas por Oliver (1991), trazendo a utilização do modelo para a literatura orçamentária. Aponta-se também a inclusão das finalidades do orçamento como variável mediadora na relação entre o isomorfismo institucional e a aceitação do orçamento.
Da fotografia documental à artística
Authors: Ward Rodolfo 
Published: May 2021

Este artigo tem a intenção de contribuir com os estudos sobre a visualidade na contemporaneidade ao focar a fotografia contemporânea e sua relação com a sociedade, principalmente na criação e manutenção de regimes de verdade e de poder da atualidade que transmutam o conceito de verdade na contemporaneidade. São abordadas as fricções entre a fotografia documental e a fotografia artística e como essas questões se imbricam com a noções de real e ficcional, de documental e artístico, para compreender as fronteiras e as transgressões da fotografia contemporânea. Como exemplo, são estudados os casos de Steve McCurry, de Andreas Gursky e da incorporação de imagens do coletivo Mídia Ninja pelo Museu de Arte Moderna de São Paulo (MAM SP).
A semana de cem anos
Authors: Coelho Fred 
Published: May 2021

Às vésperas de seu centenário, a Semana de Arte Moderna, ocorrida em fevereiro de 1922 no Teatro Municipal de São Paulo, se torna definitivamente uma efeméride nacional. A história dessa consagração, porém, é tortuosa e escrita por diferentes frentes de ação. Quase cem anos depois do evento – narrado pela sua fortuna crítica como, paradoxalmente, origem e destino da arte brasileira no século XX – sua força centrípeta paulistana e seu corte de classe colocam o arquivo modernista frente a novas perguntas e respostas sobre os impasses do Brasil contemporâneo. O artigo apresenta outros momentos em que o modernismo é questionado em sua excessiva “força fatal” e como, mesmo assim, se estabelece enquanto possibilidade transformadora de refletirmos sobre o país.
Development of a Patient-Specific p.D85N-Potassium Voltage-Gated Channel Subfamily E Member 1–Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for Drug-Induced Long QT Syndrome
Authors: Kim Maengjo , Ye Dan , John Kim C.S. , Zhou Wei , Tester David J. , Giudicessi John R. , Ackerman Michael J. 
Published: May 2021

Background:
Prior epidemiological studies demonstrated that the p.D85N-Potassium voltage-gated channel subfamily E member 1 (KCNE1) common variant reduces repolarization reserve and predisposes to drug-induced QT prolongation/torsades de pointes. We sought to develop a cellular model for drug-induced long QT syndrome using a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM).

Methods:
p.D85N-KCNE1 iPSCs were generated from a 23-year-old female with an exaggerated heart rate-corrected QT interval response to metoclopramide (ΔQTc of 160 ms). Clustered regularly interspaced short palindromic repeats-associated 9 technology was used to generate gene-corrected isogenic iPSCs. Field potential duration and action potential duration (APD) were measured from iPSC-CMs.

Results:

At baseline, p.D85N-KCNE1 iPSC-CMs displayed significantly longer field potential duration (281±15 ms, n=13 versus 223±8.6 ms, n=14,
P
<0.01) and action potential duration at 90% repolarization (APD90; 579±22 ms, n=24 versus 465±33 ms, n=26,
P
<0.01) than isogenic-control iPSC-CMs. Dofetilide at a concentration of 2 nM increased significantly field potential duration (379±20 ms, n=13,
P
<0.01) and APD90 (666±11 ms, n=46,
P
<0.01) in p.D85N-KCNE1 iPSC-CMs but not in isogenic-control. The effect of dofetilide on APD90 (616±54 ms, n=7 versus 526±54 ms, n=10,
P
<0.05) was confirmed by Patch-clamp. Interestingly, treatment of p.D85N-KCNE1 iPSC-CMs with estrogen at a concentration of 1 nM exaggerated further dofetilide-induced APD90 prolongation (696±9 ms, n=81,
P
<0.01) and caused more early afterdepolarizations (11.7%) compared with isogenic control (APD90: 618±8 ms, n=115 and early afterdepolarizations: 2.6%,
P
<0.05).

Conclusions:
This iPSC-CM study provides further evidence that the p.D85N-KCNE1 common variant in combination with environmental factors such as QT prolonging drugs and female sex is proarrhythmic.
Immediate Compared With Delayed Percutaneous Coronary Intervention for Patients With ST-Segment–Elevation Myocardial Infarction Presenting ≥12 Hours After Symptom Onset Is Not Associated With Improved Clinical Outcome
Authors: Ki You-Jeong , Kang Jeehoon , Yang Han-Mo , Woo Park Kyung , Kang Hyun-Jae , Koo Bon-Kwon , Cho Myeong-Chan , Kim Chong-Jin , Ahn Youngkeun , Jeong Myung Ho , Han Jung-Kyu , Kim Hyo-Soo ,   on behalf of investigators for Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH)
Published: May 2021

Background:
The role of immediate percutaneous coronary intervention (PCI; door-to-balloon time ≤90 minutes) in patients with ST-segment–elevation myocardial infarction who present ≥12 hours after symptom onset is still obscure. We sought to explore the clinical outcomes of immediate PCI in patients with ST-segment–elevation myocardial infarction depending on presentation time.

Methods:
Using the Korea Acute Myocardial Infarction Registry, a nationwide prospective multicenter registry in the Republic of Korea, we analyzed data from 5968 patients with ST-segment–elevation myocardial infarction. These patients were classified into the following groups: early presenters (n=5104 with symptom onset-to-door time <12 hours), late presenters (n=599 with symptom onset-to-door time 12–48 hours), and very late presenters (n=265 with symptom onset-to-door time ≥48 hours). The primary outcome was major adverse cardiac events, a composite of cardiac death, any myocardial infarction, and clinically driven target lesion revascularization.

Results:
In early presenters, immediate PCI was significantly associated with a lower rate of major adverse cardiac events compared with delayed PCI (door-to-balloon time >90 minutes; immediate versus delayed PCI, 8.6% versus 17.9%; inverse probability weighting adjusted hazard ratio, 0.63 [95% CI, 0.56–0.71]). In late presenters, immediate PCI was not associated with better major adverse cardiac events outcomes (13.0% versus 14.8%; inverse probability weighting adjusted hazard ratio, 1.05 [95% CI, 0.77–1.44]). The same trend was found for cardiac death (early presenters: immediate versus delayed PCI, 5.6% versus 14.3%; inverse probability weighting adjusted hazard ratio, 0.55 [95% CI, 0.48–0.64]; late presenters: 9.9% versus 9.8%; inverse probability weighting adjusted hazard ratio, 1.25 [95% CI, 0.86–1.82]). Very late presenters also showed the same trends as late presenters. Immediate PCI was an independent predictor of major adverse cardiac events in early presenters but not in late presenters.

Conclusions:
Immediate PCI, defined by time door-to-balloon time ≤90 minutes, for patients with ST-segment–elevation myocardial infarction who present ≥12 hours after symptom onset is not associated with improved long-term clinical outcomes as compared with delayed PCI (door-to-balloon time >90 minutes).
Valve-in-Surgical-Valve With SAPIEN 3 for Transcatheter Aortic Valve Replacement Based on Society of Thoracic Surgeons Predicted Risk of Mortality
Authors: Kaneko Tsuyoshi , Makkar Raj R. , Krishnaswamy Amar , Hermiller James , Greenbaum Adam , Babaliaros Vasilis , Shah Pinak B. , Bailey Stephen H. , Bapat Vinnie , Kapadia Samir , Abbas Amr E. 
Published: May 2021

Background:
The use of valve-in-valve–transcatheter aortic valve replacement (VIV-TAVR) in degenerated aortic bioprosthesis has been increasing, but the Food and Drug Administration approval is limited to high-risk patients. We analyzed the real-world experience of SAPIEN 3 VIV-TAVR, especially in lower-risk patients, based on the Society of Thoracic Surgeons (STS) score.

Methods:
All transfemoral VIV-TAVR with the SAPIEN 3 and Ultra valves between June 2015 and January 2020 were identified using the STS/American College of Cardiology Transcatheter Valve Therapies Registry. Patients were grouped based on STS score (low score: <4%, intermediate score: 4%≤ and≤8%, high score: >8%). Propensity-matched (1:3) analysis was conducted to compare to patients undergoing native TAVR.

Results:
Of 145 917 SAPIEN 3 TAVR patients, 4460 (3%) underwent transfemoral VIV-TAVR with available baseline STS data in 4276 patients. Average age was 73.9±11.2, 66.4% were male, and the mean STS score was 6.9±6.0%. Overall 30-day mortality was 2.4% (observed to expected ratio, 0.33), and 1-year mortality was 10.8%. 30-day mortality and observed to expected ratio were 0.9% and 0.32 in low-score, 2.2% and 0.38 in the intermediate-score, and 4.3% and 0.31 in the high-score group. Based on propensity-matched analysis, 30-day mortality was similar and 1-year mortality was lower in VIV compared to native TAVR among all risk groups. When the groups were analyzed based on the Heart Team risk stratification using high-risk and non–high risk, the findings remained consistent.

Conclusions:
In this real-world study, VIV-TAVR had excellent 30-day and 1-year outcomes, especially in lower-risk patients. These findings may suggest the feasibility and expansion of VIV-TAVR in lower-risk patients. However, long-term follow-up continues to be crucial.
Association of Lesion Pattern and Dysphagia in Acute Intracerebral Hemorrhage
Authors: Hess Felix , Foerch Christian , Keil Fee , Seiler Alexander , Lapa Sriramya 
Published: May 2021

Background and Purpose:
Dysphagia is a common and severe symptom of acute stroke. Although intracerebral hemorrhages (ICHs) account for 10% to 15% of all strokes, the occurrence of dysphagia in this subtype of stroke has not been widely investigated. The aim of this study was to evaluate the overall frequency and associated lesion locations and clinical predictors of dysphagia in patients with acute ICH.

Methods:
Our analysis included 132 patients with acute ICH. Clinical swallowing assessment was performed within 48 hours after admission. All patients underwent computed tomography imaging. Voxel-based lesion-symptom mapping was performed to determine lesion sites associated with dysphagia.

Results:
Eighty-four patients (63.6%) were classified as dysphagic. Higher scores on the National Institutes of Health Stroke Scale, larger ICH volumes, and higher degree of disability were associated with dysphagia. Voxels showing a statistically significant association with dysphagia were mainly located in the right insular cortex, the right central operculum, as well as the basal ganglia, corona radiata, and the left thalamus and left internal capsule. In contrast to lobar regions, in subcortical deep brain areas also small lesion volumes (<10 mL) were associated with a substantial risk of dysphagia. Intraventricular ICH extension and midline shift as imaging findings indicating a space-occupying effect were not associated with dysphagia in multivariate analysis.

Conclusions:
Dysphagia is a frequent symptom in acute ICH. Distinct cortical and subcortical lesion sites are related to swallowing dysfunction and predictive for the development of dysphagia. Therefore, patients with ICH should be carefully evaluated for dysphagia independently from lesion size, in particular if deep brain regions are affected.
Practice of Telehealth in Otolaryngology: A Scoping Review in the Era of COVID‐19
Authors: Gonzalez Joseph N. , Axiotakis Lucas G. , Yu Victoria X. , Gudis David A. , Overdevest Jonathan B. 
Published: May 2021

ObjectiveThe COVID‐19 pandemic has spurred widespread adoption and advancement in telehealth activities, representing a marked change in otolaryngology practice patterns. The present study undertakes a scoping review of research focused on telehealth in otolaryngology (teleotolaryngology) to identify key themes and commonly utilized outcome measures that will assist future development in this growing field.Data SourcesPubMed, Embase, and Cochrane databases and reference review.Review MethodsPer guidelines of the PRISMA Extension for Scoping Reviews, we performed database queries using a comprehensive search strategy developed in collaboration with research librarians at the Columbia University Irving Medical Center. We identified 596 unique references to undergo title and abstract review by 2 independent reviewers, leaving 439 studies for full‐text review.ResultsWe included 285 studies for extraction of notable findings, leaving 262 unique studies after accounting for content overlap. We identified core outcome measures, including patient and provider satisfaction, costs and benefits, quality of care, feasibility, and access to care. Publication volume increased markedly over time, though only 4% of studies incorporated randomized study group assignment. Using an iterative approach to thematic development, we organized article content across 5 main themes: (1) exploration of teleotolaryngology evolution, (2) role in virtual clinical encounters, (3) applications in interdisciplinary care and educational initiatives, (4) emerging and innovative technologies, and (5) barriers to implementation.ConclusionThis scoping review of teleotolaryngology documents its evolution and identifies current use cases, limitations, and emerging applications, providing a foundation from which to build future studies, inform policy decision making, and facilitate implementation where appropriate.
The diagnostic accuracy of intravoxel incoherent motion and diffusion kurtosis imaging in the differentiation of malignant and benign soft-tissue masses: which is better?
Authors: Liu Yajie , Yin Zhenzhen , Li Xiangwen , Zhang Yu , Yuan Yuan , Wei Lai , Wang Shaowu 
Published: May 2021

Background It is difficult for conventional magnetic resonance imaging (MRI) to distinguish benign soft-tissue masses (STMs) from malignant masses. Purpose To quantitatively compare the diagnostic value of intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) in STMs. Material and Methods The data from 58 patients with STMs were retrospectively analyzed. The GE Discovery 3.0-T MRI scanner was used to acquire conventional MRI sequences, IVIM, and DKI images. The chi-square test, independent sample t-test, and Mann–Whitney U tests were used to compare the differences between conventional MRI features, IVIM, and DKI parameters (Dslow, Dfast, f, mean kurtosis [MK], and mean diffusivity [MD]) between the benign and malignant groups. Receiver-operating characteristic (ROC) curve analysis was also performed. Results Tumor size and depth are statistically different in STTs. Dslow, MK, and MD values in the malignant groups are significantly lower than the benign groups ( P < 0.05). However, Dfast and f values are not statistically different between the two groups. The area under the curve (AUC) of Dslow value (0.859) is higher than MD (0.765) and MK (0.676) values for identifying benign and malignant STMs. The Dslow value showed the best specificity (82.93%). The sensitivity and specificity of IVIM and DKI parameters are higher than that of conventional MRI sequences. Conclusion IVIM and DKI can be used to distinguish between benign and malignant STMs, with Dslow as the most meaningful parameter.
Differentiation of microinfiltration and simple-edema areas in VX2 bone tumors by diffusion kurtosis imaging in animal experiments: a preliminary study
Authors: Yajun Fang , Limin Tang , Ruizhi Zhou , Qi Xu , Haisong Chen 
Published: May 2021

Background Dual-energy computed tomography, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to distinguish microinvasion areas of malignant bone tumors. However, reports of diffusion kurtosis imaging (DKI) to determine the extent of intramedullary infiltration are relatively rare. Purpose To assess the application value of MR-DKI in differentiating areas of microinfiltration and simple edema in rabbit bone VX2 tumor models. Material and Methods Conventional MRI and DKI were performed on 25 successfully constructed rabbit VX2 bone tumor models. We acquired a midline sagittal section of the tumor for hematoxylin and eosin staining. Using pathological findings as the gold standard and combining them with MRI data, strict point-to-point control was performed to delineate regions of interest (ROIs) in the microinfiltration and simple-edema areas of bone tumors for quantitative measurement of mean diffusivity (MD) and mean kurtosis (MK). MD and MK values between microinfiltration and simple-edema areas were compared using an independent sample t-test, and the diagnostic values were evaluated by receiver operating characteristic (ROC) curve analysis. Results In comparison with the simple-edema area, the micro-infiltration area demonstrated significantly smaller MD values and larger MK values ( P < 0.05), and MD showed a better area under the curve (AUC) than MK (AUC = 0.884 vs. AUC = 0.690) for distinguishing the microinfiltration area from the simple-edema area. The optimal cutoff MD value was 1108.5 mm2/s with a sensitivity of 84% and specificity of 84%. Conclusion DKI can distinguish the microinfiltration and simple-edema areas of malignant bone tumors in animal experiments.