bluuebunny/crossref_metadata_2025_split huggingface dataset:
On nonlinear pantograph fractional differential equations with Atangana–Baleanu–Caputo derivative
Authors: Abdo Mohammed S. , Abdeljawad Thabet , Kucche Kishor D. , Alqudah Manar A. , Ali Saeed M. , Jeelani Mdi Begum 
Published: January 2021

AbstractIn this paper, we obtain sufficient conditions for the existence and uniqueness results of the pantograph fractional differential equations (FDEs) with nonlocal conditions involving Atangana–Baleanu–Caputo (ABC) derivative operator with fractional orders. Our approach is based on the reduction of FDEs to fractional integral equations and on some fixed point theorems such as Banach’s contraction principle and the fixed point theorem of Krasnoselskii. Further, Gronwall’s inequality in the frame of the Atangana–Baleanu fractional integral operator is applied to develop adequate results for different kinds of Ulam–Hyers stabilities. Lastly, the paper includes an example to substantiate the validity of the results.
Enhancing innovation speed through trust: a case study on reframing employee defensive routines
Authors: Mitcheltree Christina Marie 
Published: January 2021

AbstractTrust in organizations plays an essential role for efficient innovation implementation. However, trust between managers and employees is under-communicated in relation to innovation speed. Innovation speed is related to innovation adoption, concerning new ways of performing laboratory services within the health sector. The purpose of this case study is to investigate how trust mechanisms may enhance innovation speed by reducing employee decisions to perform defensive routines. The focus is related to trust as a social condition for enhancing innovation acceptance in the context of management and organizing styles subject to the Norwegian Work Life Model.The study found that a lack of employee participation and involvement may result in emotional tension, a sense of uncertainty, disconnect, and various defensive mechanisms towards management and the innovation. Consequently, employees’ attention, loyalty, and responsibility might be redirected away from the innovation.
Effect of Zanthoxylum alkylamides on glucose metabolism in streptozotocin-induced diabetic Sprague–Dawley rats
Authors: Wang Rui , You Yu-ming , Liu Xiong 
Published: January 2021

AbstractThis research aimed at investigating the hypoglycemic effect ofZanthoxylumalkylamides and whether TRPV1 receptor could participate in the glucose metabolism by using streptozotocin-induced diabetic rat model. The results showed that the blood glucose measured in theZanthoxylumalkylamides treated group (ALK) showed significantly lower values than that in the model group (Model). Significant improvements in the oral glucose tolerance as well as plasma insulin and hepatic glycogen were also observed in the ALK group, when compared to the model group. However, the improving effects ofZanthoxylumalkylamides on glucose metabolism disorder in diabetic rats were markedly inhibited by capsazepine as the TRPV1 receptor antagonist. In addition, there were significant differences in the levels of mRNA and protein of phosphoenolpyruvate carboxylase (PEPCK), gucose-6-phosphatase (G6Pase), glucokinase (GK) and cannabinoid receptor l (CB1) in the livers of the ALK group compared to model group. Meanwhile, ALK group also exhibited a remarkable increase in the pancreatic-duodenal homeobox 1 (PDX-1), glucose transporter 2 (GLUT 2), GK levels and a significant decrease in the expression levels of CB1 in the pancreas, while the presence of capsazepine would affected the expression of these genes. These findings indicate thatZanthoxylumalkylamides could ameliorate the glucose metabolism disorder in diabetic rats. Furthermore, the TRPV1 receptor could participate in regulating the expressions of genes and proteins related to glucose metabolism and insulin secretion in the liver and pancreas, and takes a role in the hypoglycemic process ofZanthoxylumalkylamides.
Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells
Authors: Rogers Leonard C. , Zhou Jing , Baker Adriana , Schutt Charles R. , Panda Prashanta K. , Van Tine Brian A. 
Published: January 2021

Abstract
Background
Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. Consequently, ASS1-negative cells are susceptible to depletion of extracellular arginine by PEGylated arginine deiminase (ADI-PEG20), an agent currently being developed in clinical trials. As the primary mechanism of resistance to arginine depletion is re-expression of ASS1, we sought a tool to understand the temporal emergence of the resistance phenotype at the single-cell level.

Methods
A real-time, single-cell florescence biosensor was developed to monitor arginine-dependent protein translation. The versatile, protein-based sensor provides temporal information about the metabolic adaptation of cells, as it is able to quantify and track individual cells over time.

Results
Every ASS1-deficient cell analyzed was found to respond to arginine deprivation by decreased expression of the sensor, indicating an absence of resistance in the naïve cell population. However, the temporal recovery and emergence of resistance varied widely amongst cells, suggesting a heterogeneous metabolic response. The sensor also enabled determination of a minimal arginine concentration required for its optimal translation.

Conclusions
The translation-dependent sensor developed here is able to accurately track the development of resistance in ASS1-deficient cells treated with ADI-PEG20. Its ability to track single cells over time allowed the determination that resistance is not present in the naïve population, as well as elucidating the heterogeneity of the timing and extent of resistance. This tool represents a useful advance in the study of arginine deprivation, while its design has potential to be adapted to other amino acids.
Anxiety among dental professionals and its association with their dependency on social media for health information: insights from the COVID-19 pandemic
Authors: Al-Amad Suhail H. , Hussein Amal 
Published: January 2021

Abstract
Background
Social media can play a detrimental role during a global health emergency. In this study, we aimed at assessing the impact social media has on the anxiety level of dental healthcare workers (DHCWs) whilst living through the COVID-19 pandemic.

Methods
An online questionnaire was disseminated to a cross-sectional sample of DHCWs from 19 countries using social media platforms. The questionnaire enquired about DHCWs’ frequency of using social media and their dependency on health-related information posted on those platforms. Anxiety was measured using General Anxiety Disorder scale (GAD-7).

Results
Four-hundred and three (403) DHCWs completed the online questionnaire. Sixty-eight percent (68%) frequently use social media for information on COVID-19. The frequency of social media use was higher among younger DHCWs, with shorter clinical experience, and holders of undergraduate qualifications (p = 0.009, p = 0.002, and p = 0.023, respectively). Almost one third of DHCWs had moderate to severe anxiety (31.7%), which was significantly associated with the frequency of social media use (p = 0.016). This association was adjusted for age, years of experience and qualification level (OR 1.75; 95% CI 1.05–2.93; p = 0.032).

Conclusion
COVID-19 social media infodemic has been adversely impacting the psychological wellbeing of DHCWs. More effective measures are needed to control the quality and spreadability of health information on social media platforms.
Change in quality of life and self-esteem in a randomized controlled CBT study for anxious and sad children: can targeting anxious and depressive symptoms improve functional domains in schoolchildren?
Authors: Martinsen Kristin D. , Rasmussen Lene-Mari P. , Wentzel-Larsen Tore , Holen Solveig , Sund Anne Mari , Pedersen Marit Løtveit , Løvaas Mona Elisabeth S. , Patras Joshua , Adolfsen Frode , Neumer Simon-Peter 
Published: January 2021

AbstractBackgroundQuality of life and self-esteem are functional domains that may suffer when having mental problems. In this study, we examined the change in quality of life and self-esteem when targeting anxious and depressive symptoms in school children (8–12 years) using a CBT-based transdiagnostic intervention called EMOTION, Kids Coping with anxiety and depression. The aim of this study was to investigate quality of life and self-esteem in children with elevated levels of anxious and depressive symptoms, and further if the EMOTION intervention could influence these important functional domains.MethodsThe study had a clustered randomized design (cRCT), whereN = 795 children recruited from 36 schools participated. The children were included based on self-reports of anxious and depressive symptoms. Schools were the unit of randomization and were assigned to intervention or control condition. Children in the intervention condition received the 10-week EMOTION intervention. Mixed effects models were used to take account of the possible clustering of data. Separate models were estimated for the dependent variables.ResultsChildren with elevated levels of anxious and depressive symptoms reported lower levels of quality of life and self-esteem compared to normative samples, with girls and older children reporting the lowest levels. For both genders and older children, a large and significant increase in quality of life and self-esteem was found among the children who received the intervention compared to the children in the control condition. Children in the intervention group reporting both anxious and depressive symptoms showed a significantly larger increase in both quality of life and self-esteem compared to the controls. Reductions in quality of life and self-esteem were partially mediated by reductions in symptoms of anxiety and depression.ConclusionsParticipating in an intervention targeting emotional symptoms may have a positive effect on quality of life and self-esteem in addition to reducing anxious and depressive symptoms. Improved quality of life may increase the child’s satisfaction and subjective perception of wellbeing. As low self-esteem may lead to anxious and depressive symptoms, improving this functional domain in children may make them more robust dealing with future emotional challenges.Trial registrationNCT02340637, retrospectively registered
Optimization of subcritical water extraction of phenolic compounds from Ziziphus jujuba using response surface methodology: evaluation of thermal stability and antioxidant activity
Authors: Niazmand Razieh , Shahidi Noghabi Mostafa , Niazmand Azam 
Published: January 2021

Abstract
Background
The jujube is mainly grown in the subtropical and tropical regions of Asia. Due to owning bioactive compounds such as polyphenols, it was considered as medicinal and nutritional plant in traditional medicine. This study aimed to extract phenolic compounds from Ziziphus jujuba using subcritical water (SCW) process. The possible combinations of temperature, time, and fruit-to-solvent ratio were investigated using response surface methodology.

Results
The total phenolic compounds (TPC) and radical scavenging capacity (RSC) of 975.94 mg/g and 53.98%, respectively, were recovered at optimum extraction conditions (170 °C, 74.49 min, and fruit-to-solvent ratio of 1:5.29). The extract obtained in SCW optimum conditions was put under thermal treatments including low temperature long time, high temperature short time, cooking, baking, and sterilization. The results showed after baking, the amount of TPC, RSC, and absorbance at 420 nm increased. The quantity of gallic acid, chlorogenic acid, p-coumaric acid, ferulic acid, and rutin increased significantly. The efficiency of SCW extract in retarding lipid oxidation in bulk oil and O/W emulsion model was investigated at 50 °C for 10 days. After 10 days, the peroxide value of bulk oil (1.1 meq O2/kg) containing SCW extract was lower than O/W emulsion model (2.2 meq O2/kg).

Conclusion
The subcritical extracted phenolic compounds seem to have good antioxidant activity as well as thermal stability for using in food or drug industries.
The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?
Authors: Wildi Karin , Livingstone Samantha , Palmieri Chiara , LiBassi Gianluigi , Suen Jacky , Fraser John 
Published: January 2021

AbstractThe acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing pharmacological agents to treat ARDS, its mortality rate remains unaltered high and treatment is still only supportive. Over the years, there have been many attempts to identify meaningful subgroups likely to react differently to treatment among the heterogenous ARDS population, most of them unsuccessful. Only recently, analysis of large ARDS cohorts from randomized controlled trials have identified the presence of distinct biological subphenotypes among ARDS patients: a hypoinflammatory (or uninflamed; named P1) and a hyperinflammatory (or reactive; named P2) subphenotype have been proposed and corroborated with existing retrospective data. The hyperinflammatory subphenotyope was clearly associated with shock state, metabolic acidosis, and worse clinical outcomes. Core features of the respective subphenotypes were identified consistently in all assessed cohorts, independently of the studied population, the geographical location, the study design, or the analysis method. Additionally and clinically even more relevant treatment efficacies, as assessed retrospectively, appeared to be highly dependent on the respective subphenotype. This discovery launches a promising new approach to targeted medicine in ARDS. Even though it is now widely accepted that each ARDS subphenotype has distinct functional, biological, and mechanistic differences, there are crucial gaps in our knowledge, hindering the translation to bedside application. First of all, the underlying driving biological factors are still largely unknown, and secondly, there is currently no option for fast and easy identification of ARDS subphenotypes. This narrative review aims to summarize the evidence in biological subphenotyping in ARDS and tries to point out the current issues that will need addressing before translation of biological subohenotypes into clinical practice will be possible.
Effect of data conserving respiratory motion compensation on left ventricular functional parameters assessed in gated myocardial perfusion SPECT
Authors: Kortelainen Matti J , Koivumäki Tuomas M , Vauhkonen Marko J , Hakulinen Mikko A 
Published: January 2021

Abstract
Background
Respiratory motion compromises image quality in myocardial perfusion (MP) single-photon emission computed tomography (SPECT) imaging and may affect analysis of left ventricular (LV) functional parameters, including phase analysis-quantified mechanical dyssynchrony parameters. In this paper, we investigate the performance of two algorithms, respiratory blur modeling (RBM) and joint motion-compensated (JMC) ordered-subsets expectation maximization (OSEM), and the effects of motion compensation on cardiac-gated MP-SPECT studies.

Methods
Image acquisitions were carried out with a dual-detector SPECT/CT system in list-mode format. A cardiac phantom was imaged as stationary and under respiratory motion. The images were reconstructed with OSEM, RBM-OSEM, and JMC-OSEM algorithms, and compared in terms of mean squared error (MSE). Subsequently, MP-SPECT data of 19 patients were binned into dual-gated (respiratory and cardiac gating) projection images. The images of the patients were analyzed with Quantitative Gated SPECT (QGS) 2012 program (Cedars-Sinai Medical Center, USA). The parameters of interest were LV volumes, ejection fraction, wall motion, wall thickening, phase analysis, and perfusion parameters.

Results
In phantom experiment, compared to the stationary OSEM reconstruction, the MSE values for OSEM, RBM-OSEM, and JMC-OSEM were 8.5406·10−5,2.7190·10−5, and 2.0795·10−5, respectively. In the analysis of LV function, use of JMC had a small but statistically significant (p < 0.05) effect on several parameters: it increased LV volumes and standard deviation of phase angle histogram, and it decreased ejection fraction, global wall motion, and lateral, septal, and apical perfusion.

Conclusions
Compared to standard OSEM algorithm, RBM-OSEM and JMC-OSEM both improve image quality under motion. Motion compensation has a minor effect on LV functional parameters.
Resorption of retromolar bone grafts after alveolar ridge augmentation—volumetric changes after 12 months assessed by CBCT analysis
Authors: Stricker Andres , Jacobs Reinhilde , Maes Frederik , Fluegge Tabea , Vach Kirstin , Fleiner Jonathan 
Published: January 2021

AbstractIn this pilot study, a volumetric analysis of retromolar onlay bone grafts over a period of 12 months was conducted, using repeated CBCT imaging combined with automated image registration.Eleven patients being treated with 16 bone grafts taken from the retromolar area were examined by CBCT scanning prior to bone augmentation (T0), immediately after bone augmentation (T1) and after a healing time of 12 months after augmentation (T2). Graft volumes were measured at each time point after automated image registration of consecutive CBCT scans.The mean volume of the augmented site was 372.2 ± 179.4 mm3. Resorption relative to the original augmented volume was 43.7% ± 19.0% after 12 months.Three-dimensional graft resorption could be precisely depicted by the use of automated image registration for CBCT data over a period of 12 months and demonstrated extensive volumetric changes of bone grafts taken from the ascending ramus of the mandible.Graft resorption and continuous bony remodeling of the grafted site before and after implant insertion have to be carefully considered by the clinician.
First documented record of the leatherback turtle (Dermochelys coriacea) from Djibouti waters
Authors: Boldrocchi Ginevra , Schmidt Jennifer V. , Robinson David P. 
Published: January 2021

AbstractA subadult leatherback turtle was documented in the Gulf of Goubet (Djibouti) during a research expedition. This sighting confirms for the first time previous anecdotal observations of the occurrence of the leatherback turtle, Dermochelys coriacea (Vandelli, 1761), in Djibouti waters. Coupled with observations from fishers, this finding underlines the urgent need to carry out research programs to evaluate the species habitat use within Djibouti waters, and to review the species distribution in the Gulf of Aden. Although marine turtles are protected in Djibouti, illegal harvest and entanglement in fishing gear pose a threat to their survival, and conservation measures should be implemented.
Activity competence among infants and toddlers with developmental disabilities: Rasch analysis of the Infant Toddler Activity Card Sort (ITACS)
Authors: Hoyt Catherine R. , L’Hotta Allison J. , Bauer Anna H. , Chang Chih-Hung , Varughese Taniya E. , Abel Regina A. , King Allison A. 
Published: January 2021

AbstractBackgroundDevelopment is rapid in the first years of life. Developmental delays appearing during this critical period have the potential to persist throughout the child’s life. Available standardized assessments for this age record a child’s ability to successfully complete discrete skills but fail to capture whether the child incorporates those skills into daily routines that are meaningful to the child and family. The Infant Toddler Activity Card Sort (ITACS) is a newly developed photograph-based early intervention tool to measure the participation-related concept of activity competence using caregiver report. The purpose of the present study was to use Rasch analysis to determine if ITACS items comprehensively measure the construct of child activity competence.ResultsA total of 60 child/caregiver dyads participated. The dichotomous caregiver-reported responses (present vs. absent) on the 40 individual ITACS items were used in Rasch analysis, and three iterations of the model were completed. The final model included 51 child/caregiver dyads and 67 ITACS assessments with a good spread of individual ability measure (6.47 logits). All items demonstrated adequate infit except for “sleeping” (range 0.68–1.54). Five items (sleeping, eating at restaurants, brushing teeth, crawling, and interact with pets) demonstrated high Mean Square (MNSQ) outfit statistics and one (take a bath) demonstrated low MNSQ outfit. ITACS items demonstrated a good spread of item difficulty measures (6.27 logits), and a clear ceiling was observed. Three activity items (smiling, breastfeeding, and playing with adults) were rarely endorsed as concerns. The activities most likely to be reported as challenging were “crying/communicating” and “going to school”. Person and item reliability statistics were adequate (0.79 and 0.80, respectively). The separation between individuals and between items were adequate to good (1.96 and 1.99, respectively).ConclusionsFindings indicate that ITACS items are measuring a unidimensional construct--activity competence in early childhood. The Rasch analysis of caregiver responses suggest that some activities are more likely to be considered challenging and may be important targets for intervention. These results provide evidence to further validate the ITACS as a caregiver report measure and support its use in the early intervention setting to facilitate caregiver driven goal development.
A challenging case of a successful outcome of cesarean section with combined spinal–epidural technique in a parturient with Eisenmenger syndrome
Authors: Gehlot Ravindra Kr. , Verma Devendra , Raiger L. K. 
Published: January 2021

AbstractBackgroundEisenmenger syndrome belongs to the 0.4–4.1% (incidence) rarely encountered congenital cardiac lesions in pregnancy. Management of a pregnant patient with Eisenmenger syndrome is a challenging task for the anesthesiologist.Case presentationHere, we report the successful outcome with the use of low-dose sequential combined spinal–epidural (CSE) anesthesia in a patient with Eisenmenger syndrome posted for cesarean section. Low-dose sequential CSE anesthesia was adequate for the performance of cesarean section with minimal hemodynamic changes and good fetal outcome.ConclusionLow-dose sequential CSE can be a safe alternative to achieve good anesthesia with hemodynamic stability in such case.
A conceptual design for deflection device in VTDP system
Authors: Gao Yongwei , Zhang Jianming , Wang Long , Chen Bingzhen , Wei Binbin 
Published: January 2021

AbstractThe effectiveness of the Vectored Thrust Ducted Propeller (VTDP) system is not high currently, especially the lateral force is not large enough. Thus, a conceptual design for a deflection device of a VTDP system was proposed to achieve effective hovering control. The magnitude of the lateral force that was applied to maintain balance while hovering was examined. A comparison between the experimental and numerical results for the 16H-1 was made to verify the numerical simulation approach. The deflection devices of the X-49 and the proposed design were analyzed using numerical simulations. The results indicated that a larger lateral force and lower power consumption were presented in the proposed design. The results of this article provide a new idea for the design of the VTDP system.