bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of Azithromycin and Amoxicillin/clavulanate for otitis media in children: a systematic review and meta-analysis of randomized controlled trials
Authors: Tesfai Gabriel , Abay Solomon , Makonnen Eyasu 
Published: March 2021

Abstract
BackgroundResistance, prolonged therapy and more adverse reactions made amoxicillin less preferred for treating otitis media. The aim of this study was to compare the efficacy and safety of azithromycin and amoxicillin/clavulanate for treatment of otitis media in children.MethodologyThis study was a systematic review and meta-analysis. PubMed, Cochrane library and Google scholar databases were searched. Comparative RCT studies between azithromycin and amoxicillin/clavulanate to treat otitis media in children published up to 30 September 2019 were included. Risk of bias was assessed and Data was extracted by the first author and checked by second author. Meta-analysis was performed by STATA software version 16, and Mantel-Haenszel statistical method with effect measure odds ratio was employed for analysis.Result751 records were identified and 14 studies were eligible for analysis. In 12 studies azithromycin had equivalent clinical efficacy and 2 had less to amoxicillin/clavulanate. Meta-analysis results showed small statistical difference on efficacy in favor of amoxicillin/clavulanate after completion of treatment OR 0.75, 95% CI (0.62–0.91). On subgroup analysis for children less than 2 year (OR 0.96 95% CI (0.49–2.29), and greater than 2 year (OR 1.40 95% CI (0.93–2.11) and also efficacy on follow up (OR 0.97 95% CI (0.83–1.15) there is no statistical significant difference. The clinical adverse events are more in amoxicillin/clavulanate group than in azithromycin with statistical significant difference OR 0.46 95% CI (0.43–0.56).ConclusionAzithromycin is not inferior to amoxicillin/clavulanate to treat otitis media in children, and it is safer and more tolerable.
Simulation-based Machine Learning for Optoelectronic Device Design: Perspectives, Problems, and Prospects
Authors: Piprek Joachim 
Published: March 2021

Abstract
Numerical simulation and machine learning represent opposite approaches to computational analysis of the real world, deductive vs. inductive. However, both methods suffer from various uncertainties and even their combination often fails to link theory and reality. Focusing on GaN-based light-emitting diode (LED) design optimization, this paper evaluates examples of simulation-based machine learning from a physics point of view. Strategies are suggested for achieving more realistic predictions.
Age-appropriate vaccination coverage and its determinants in children aged 12-36 months in Nepal: a national and subnational assessment
Authors: Rauniyar Santosh Kumar , Iwaki Yoko , Yoneoka Daisuke , Hashizume Masahiro , Nomura Shuhei 
Published: March 2021

Abstract
Background Vaccination is one of the effective ways to develop immunity against potential life-threatening diseases in children in early age. This study is focused on analysing the age-appropriate vaccination coverage at national and subnational levels and identify the factors associated with age-appropriate coverage in Nepal.Methods 460 children aged 12-36 months were included in the study. The data was obtained from Nepal Demographic and Health Survey (NDHS) 2016-17. Age-appropriate coverage of Bacillus Calmette-Guerin vaccine (BCG), oral polio vaccine (OPV) doses 1-3, pentavalent vaccine (PE) doses 1-3, and first dose of measles, mumps, and rubella vaccine (MMR) were estimated using Kaplan Meier method. Multilevel logistic regression with random intercept was used to identify the factors associated with age-appropriate vaccination. Results The crude coverage of the vaccines included in the study ranged from 91.5% (95% CI, 88.5-93.7) for PE3 to 97.8% (95.8-98.7) for BCG. Although the crude coverage of all the vaccines was above 90%, the age-appropriate coverage was significantly low, ranging from 41.5% (36.5-46.6) for PE3 to 73.9 % (69.2-78.1) for PE1. Furthermore, high disparity in timely vaccination coverage was observed at regional level. Compared to the age-appropriate vaccination coverage in other provinces, Province 2 had the lowest coverage of all, followed by that in Province 6. The timeliness of vaccination was significantly associated with subnational regions i.e., provinces and the season of childbirth.Conclusion Although the immunization program in Nepal has achieved the target of 90% crude coverage of all the childhood vaccines, the age-appropriate coverage is significantly low which undermines the effectiveness of the vaccines administered. Thus, along with crude coverage, timeliness of the vaccines administered should be taken into consideration and thoroughly monitored at national and subnational levels. Provincial government should formulate tailored strategies to ensure the timely administration of the childhood vaccines.
WD40 Repeat 43 Mediates Cell Survival, Proliferation, Migration and Invasion via Vimentin in Colorectal Cancer
Authors: Li Zijian , Feng Min , Zhang Jie , Wang Xingzhou , Xu En , Wang Chao , Lin Fengcen , Yang Zhi , Yu Heng , Guan Wenxian , Wang Hao 
Published: March 2021

Abstract
BackgroundWD40 repeat (WDR)43 is an RNA-binding protein that belongs to the WDR domain protein family. Its biological function is largely unclear, particularly in colorectal cancer (CRC). MethodsIn the present study, we searched the TCGA database and found the correlation between WDR43 and CRC. Subsequently,the high expression of WDR43 in human clinical samples of CRC was validated and we further examined the biological functions of it in CRC cells.Finally,we explored potential downstream proteins or pathways and established subcutaneous xenograft model to verify our findings.ResultsImmunohistochemistry of 16 patient specimens confirmed that the expression of WDR43 was elevated in CRC. WDR43 knockdown was shown to increase apoptosis and inhibit the proliferation, migration and invasion of CRC cells in vitro and reduce tumorigenesis in animal models.In addition, it was found that WDR43 knockdown inhibited vimentin (VIM) expression in CRC cells and overexpression of VIM can partially reverse the effects of WDR43 both in vitro and in vivo. ConclusionIn conclusion, the role of WDR43 in the occurrence and development of CRC was investigated in the present study. WDR43 may serve as a valuable biomarker and provide new options for the diagnosis and treatment of colorectal cancer.
Anatomical Identification of Ischial Spines Applicable to Intrapartum Transperineal Ultrasound Based on Magnetic Resonance Imaging of Pregnant Women
Authors: Yano Eriko , Iriyama Takayuki , Hanaoka Shouhei , Sayama Seisuke , Ichinose Mari , Toshimitsu Masatake , Seyama Takahiro , Sone Kenbun , Kumasawa Keiichi , Nagamatsu Takeshi , Kobayashi Koichi , Fujii Tomoyuki , Osuga Yutaka 
Published: March 2021

Abstract
Intrapartum transperineal ultrasound (ITU) is considered useful in judging fetal head descent; however, the inability to detect ischial spines on ITU has been a drawback to its legitimacy. The current study aimed to determine the anatomical location of ischial spines, which can be directly applied to ITU. Based on magnetic resonance imaging of 67 pregnant women at 33+ 2 [31+ 6-34+ 0] weeks gestation (median [interquartile range: IQR]), we calculated the angle between the pubic symphysis and the midpoint of ischial spines (midline symphysis-ischial spine angle; mSIA), which is theoretically equivalent to the angle of progression at fetal head station 0 on ITU, by determining spatial coordinates of pelvic landmarks and utilizing spatial vector analysis. Furthermore, we measured symphysis-ischial spine distance (SID), defined as the distance between the vertical plane passing the lower edge of the pubic symphysis and the plane that passes the ischial spines. As a result, mSIA was 109.6 ° [105.1–114.0] and SID 26.4 mm [19.8–30.7] (median, [IQR]). There was no correlation between mSIA or SID and maternal characteristics, including physique. Our results provide valuable evidence to enhance the reliability of ITU in assessing fetal head descent by considering the location of ischial spines.
Numerical Simulation and Experimental Research on Rubber Flexible-Die Forming Limitation with New Position-Limited Back Pressure Mechanism
Authors: Han Zhi-ren , Wei Chuang , Du Si-min , Jia Zhen , Du Xin-yang 
Published: March 2021

Abstract
The forming limitation and the wall thickness distribution are two main parameters for estimating the forming quality of T-shaped tube. In this paper, the effects of three key factors on the forming limitation and the wall thickness distribution are investigated, which are punch front distance l1, reverse height h1 and matching relationship between rubber hardness and axial feed Δl. A new position-limited back pressure mechanism is proposed which is made up of rigid position-limited lever, flexible back pressure medium and rigid spacer. The simulations and experiments are carried out. Both results show the thinning rate of the wall thickness decreases first and then increases and the thickening rate decreases gradually with the increase of l1. The branch reaches the highest with the l1 of 5mm under the requirements of thinning rate and thickening rate. With the increase of reverse height h1, the bigger h1 is beneficial to the wall thickness thinning suppress at the top of branch, the highest branch was formed when h1 is 7mm. When Δl is fixed, the rubber hardness has a great influence on the forming defects, higher rubber hardness causes the top of branch to rupture and lower causes the wall to wrinkle. When rubber hardness is fixed, the thickening rate decreases with the increase of Δl. The best forming limitation and thickness distribution are achieved with the punch front distance l1 of 5mm, the reverse height h1 of 7mm, the rubber hardness of 70HA and the axial feed Δl of 24mm.
Virtualized Clinical Studies to Assess the Natural History and Impact of Gut Microbiome Modulation in Non-Hospitalized Patients with Mild to Moderate COVID-19 a Randomized, Open-Label, Prospective Study with a Parallel Group Study Evaluating the Physiologic Effects of KB109 on Gut Microbiota Structure and Function: A Structured Summary of a Study Protocol for a Randomized Controlled Study
Authors: Haran John P , Pinero Jose C , Zheng Yan , Alonzo-Palma Norma , Wingertzahn Mark 
Published: March 2021

Abstract
Objectives These 2 parallel studies (K031 and K032) aim to evaluate the safety of KB109 in addition to supportive self-care (SSC) compared with SSC alone in outpatients with mild to moderate coronavirus disease 2019 (COVID-19). KB109 is a novel synthetic glycan that was formulated to modulate the gut microbiome composition and metabolic output in order to increase beneficial short-chain fatty acid (SCFA) production in the gut. The K031 study is designed to evaluate the safety of KB109 and characterize its impact on the natural progression of COVID-19 in patients with mild to moderate disease. The K032 study is evaluating the effect of KB109 on the gut microbiota structure and function in this same patient population. Additionally, both studies are evaluating measures of health care utilization, quality of life (QOL), laboratory indices, biomarkers of inflammation, and serological measures of immunity in patients who received SSC alone or with KB109. Noteworthy aspects of these outpatient studies include study design measures aimed at limiting in-person interactions to minimize the risk of infection spread, such as use of online diaries, telemedicine, and at-home sample collection.
Increases in Adipose Tissue and Muscle Function are Longitudinally Associated with Better Quality of Life in Colorectal Cancer Survivors
Authors: Kenkhuis Marlou-Floor , Roekel Eline H. Van , Koole Janna L. , Breedveld-Peters José J.L. , Breukink Stephanie O. , Janssen-Heijnen Maryska L.G. , Keulen Eric T.P. , Duijnhoven Fränzel J.B. van , Mols Floortje , Weijenberg Matty P. , Bours Martijn J.L. 
Published: March 2021

Abstract
Background: Colorectal cancer (CRC) survivors need evidence-based guidelines pertaining to post-treatment body composition, which could benefit health-related quality of life (HRQoL). We aimed to describe the course of several body composition measures, and to assess longitudinal associations of these measures with HRQoL, fatigue and chemotherapy-induced peripheral neuropathy (CIPN). Methods: In a prospective cohort among stage I-III CRC survivors (n=459), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Body mass index (BMI), waist circumference and fat percentage were assessed as measures of adiposity, and muscle arm circumference and handgrip strength as measures of muscle mass and function. We applied linear mixed-models to describe changes in body composition over time and to analyze overall longitudinal associations.Results: Of included participants, 44% was overweight and 31% was obese at diagnosis. All body composition measures followed similar trends, decreasing from diagnosis to 6 weeks and then increasing up to 24 months post-treatment. In confounder-adjusted mixed models, increases in adipose tissue and muscle function were longitudinally associated with better HRQoL and less fatigue, regardless of pre-treatment body composition.Discussion: With regards to improving HRQoL, decreasing fatigue and CIPN, clinical practice should also focus on restoring body tissues after CRC treatment.
Flood Hydrograph Coincidence Analysis of the Upper Yangtze River and Dongting Lake, China
Authors: Zhang Chao , Ji Changming , Wang Yi , Xiao Qian 
Published: March 2021

Abstract
In hydrological research, flood events can be analyzed by flood hydrograph coincidence. Existing flood hydrograph coincidence research mostly focuses on the analysis of the coincidence risk probability of the annual maximum flood event using the 15-day maximum annual flood volume; the actual duration of the flood hydrograph is neglected. The duration of the flood hydrograph is a key variable in (1) determining whether flood hydrograph coincidence occurs, and (2) accurately calculating the flood hydrograph coincidence risk probability. This paper creatively proposes a novel method to analyze the flood hydrograph coincidence risk probability by establishing a five-dimensional joint distribution of flood volumes, durations and interval time for two hydrologic stations. More specifically, using the annual maximum flood of the upper Yangtze River and input from Dongting Lake as an example, the Pearson Type III and the mixed von Mises distributions were used to establish the marginal distribution of flood volumes, flood duration and interval time. Subsequently, the five-dimensional joint distribution based on vine copula was established to analyze the flood hydrograph coincidence risk probability. The results were verified by comparison with a historical flood sequence. The flood hydrograph coincidence volume-risk probability curve was also obtained, providing theoretical support for flood control safety and risk management in the middle and lower Yangtze River. This study also demonstrates the significant beneficial role of regulation by the Three Gorges Water Conservancy Project in mitigating flood risk of the Yangtze River.
Dissolved silica-catalyzed disordered dolomite precipitation
Authors: Fang Yihang , Xu Huifang 
Published: March 2021

AbstractThere is a great abundance of sedimentary dolomite in the Proterozoic and Lower Paleozoic, but examples of primary dolomite are scarce in the Cenozoic. This discrepancy suggests a poorly understood but dramatic shift in the geochemical system that inhibited dolomite formation. Previous research on microbial-mediated dolomite formation demonstrated that microbial activity could promote disordered dolomite precipitation through the catalytic role of polysaccharides. However, the microbial-mediated model cannot explain some of the Precambrian dolomite for which there is no evidence of microbial origin. Here, we present an abiotic mechanism with dissolved silica catalyzed dolomite precipitation that provides new insight into this long-lasting “dolomite problem.” In this study, we demonstrate that the presence of 1–2 mM of aqueous Si(OH)4 in high Mg:Ca ratio solutions at room temperature will promote disordered dolomite precipitation (with up to 48.7 mol% MgCO3) and inhibit aragonite formation. Dissolved silica in solution also promotes Mg incorporation into the Ca-Mg carbonates. Dissolved silica possesses low-dipole moment and dielectric constant similar to hydrogen sulfide, dioxane, polysaccharide, and exopolymeric substances (EPS), which are catalysts in previously established room-temperature dolomite synthesis. The molecules with low-dipole moment adsorbed on the dolomite surface can lower the dehydration energy barrier of a surface Mg2+-water complex and promote dolomite nucleation and growth. This study provides a new model for abiotic sedimentary dolomite formation, which is likely to be responsible for the significant amount of primary dolomite in Earth history.
Element mobility and oxygen isotope systematics during submarine alteration of basaltic glass
Authors: He Miaohong , Zhang Shudi , Zhang Le , Yang Fan , Zhang Yanqiang , Huang Xiaolong , Wei Gangjian 
Published: March 2021

Abstract
Studies of the submarine alteration of basaltic glass may improve the understanding of crust-seawater interactions and the oceanic elemental cycle. Natural alteration processes such as the palagonitization of basaltic glass are complex, and their elucidation is crucial to the understanding of fluid-rock interactions. This study involves major and trace element and isotope mapping of a submarine-altered basaltic glass grain and reveals sequential development of alteration textures toward the grain core through the transition between unaltered glass and palagonite. The conversion from basaltic glass to palagonite in a low-temperature submarine environment results in enrichment in B, Rb, K, Li, H2O, U, Nb, Th, Ti, Cu, Ta, Zr, Hf, Ni, Sc, Fe, Cr, Pb, and Zn; and depletion in Si, Mg, Al, Sr, Na, Co, rare-earth elements, Ca, P, and V (in order of decreasing distribution coefficient). The glass-palagonite interface region has the highest high field strength element (HFSE) and Fe-Ti contents but the lowest Mg content, indicating that the Fe-Ti phases that host HFSE were precipitated first during initial palagonitization. At the same time, an inferred exchange of oxygen occurred, based on variation in δ18O, with values increasing from basaltic glass to palagonite. However, initial palagonite compositions were affected by subsequent precipitation and/or incorporation/adsorption of additional compounds such as Mg(OH)2 scavenged from pore water.
The study of Cu/Fe-doped Al-MCM-41 to degrade Rhodamine B
Authors: Li Shunyi , Wang Shaohua , Chen Qiang , Jiang Suyu , Sun Shaohui 
Published: March 2021

Abstract
Textile wastewater has been recognized as one of the most difficult to treat environmental problems. Aiming to acquire an excellent treatment effect that could meet the stringent discharge regulations, a series of Cu- and Fe-doped Al-MCM-41 heterogeneous Fenton catalysts with different metal contents (1.21–3.45 wt%) were successfully synthesized by co-precipitation method to degrade Rhodamine B. Their physicochemical properties were analysed by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, nitrogen physisorption and scanning electron microscopy. The incorporation of metal did not alter MCM-41's mesostructure, but increasing the contents of metal would decrease the order of MCM-41s’ structure. The effects of temperature, pH, H2O2 dosage, dye concentration and the dosage of catalysts on Rhodamine B degradation were also investigated. It was found that M2 with 2.71 wt% of active metals performed best on Rhodamine B degradation. For the high concentration of Rhodamine B (400 mg/L), the decolorization efficiency could reach 96.0% using only 40 mM H2O2 within 50 min at 60 °C. Further adding 40 mM of H2O2, the chemical oxygen demand removal reached 75.1% after 100 min. M2 showed excellent stability and could be reused at least three times without any obvious deterioration in catalytic activity. M2 fitted well with the Freundlich isotherms and the first-order rate model.
Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s
Disease Agents: A Moiety Based Review
Authors: Teli Pankaj , Sahiba Nusrat , Soni Jay , Sethiya Ayushi , Agarwal Dinesh Kumar , Agarwal Shikha 
Published: March 2021

Abstract:
Dementia is a chronic neurodegenerative disease, and a maximum number of the cases are
directly related to Alzheimer’s disease. More than 4 million people are living with Alzheimer’s
disease-related dementia in India, making it a national crisis. Alzheimer’s disease deteriorates
cognitive functions with the passage of time and consists of multi-faceted factors, such as the decline
of acetylcholine level, amyloid β-aggregation, tau hyperphosphorylation, oxidative stress, etc. The
classical drugs used to date, are focused on only one target and are not serving the cause properly.
Hence, the community of scientists is rigorously working on multi-target-directed agents that
incorporate two or more active scaffolds in one compound or hybrid of active moieties. This article
aims to evaluate novel potential compounds and moieties, such as quinolines, chalcones, coumarins,
chromenes, piperazine, carbazoles, cinnamic acids, tacrine hybrids, donepezil hybrids, etc., that have
been introduced as multi-target-directed agents in the recent five years.