bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hamiltonian analysis of Mimetic gravity with higher derivatives
Authors: Zheng Yunlong 
Published: January 2021

Abstract
Two types of mimetic gravity models with higher derivatives of the mimetic field are analyzed in the Hamiltonian formalism. For the first type of mimetic gravity, the Ricci scalar only couples to the mimetic field and we demonstrate the number of degrees of freedom (DOFs) is three. Then in both Einstein frame and Jordan frame, we perform the Hamiltonian analysis for the extended mimetic gravity with higher derivatives directly coupled to the Ricci scalar. We show that different from previous studies working at the cosmological perturbation level, where only three propagating DOFs show up, this generalized mimetic model, in general, has four DOFs. To understand this discrepancy, we consider the unitary gauge and find out that the number of DOFs reduces to three. We conclude that the reason why this system looks peculiar is that the Dirac matrix of all secondary constraints becomes singular in the unitary gauge, resulting in extra secondary constraints and thus reducing the number of DOFs. Furthermore, we give a simple example of a dynamic system to illustrate how gauge choice can affect the number of secondary constraints as well as the DOFs when the rank of the Dirac matrix is gauge dependent.
Autismus-Spektrum-Störungen: von der Früherfassung zu Intervention und Begleitung
Authors: Hofer Johannes , Fellinger Johannes 
Published: January 2021

ZusammenfassungAutismus-Spektrum-Störungen zeigen eine Prävalenz von 1 %. Die unterschiedlich stark ausgeprägte, soziale Interaktions- und Kommunikationsstörung ist gekennzeichnet durch eingeschränkte Fähigkeit, sich sprachlich und nichtsprachlich auf andere Menschen einzustellen. Weitere Kernsymptome sind repetitive und stereotype Verhaltens- und Interessenmuster.Symptome einer Autismus-Spektrum-Störung zeigen sich überwiegend bereits während des Kleinkindalters und persistieren meist über die Lebensspanne in unterschiedlicher Phänomenologie und unterschiedlichem Ausprägungsgrad.Wichtige abzugrenzende, aber auch begleitende Störungen bei jungen Kindern sind: kognitive Entwicklungsstörungen, Aufmerksamkeitsdefizit- und Hyperaktivitätssyndrom und Sprachstörungen.Früherkennung ist häufig bereits im zweiten Lebensjahr möglich. Evidenzbasierte, effektive Frühinterventionsmodelle existieren, sind aktuell aber im deutschsprachigen Raum noch nicht flächendeckend verfügbar.Angesichts der hohen Belastung für Familie und Umfeld ist ein kompetentes ärztliches Case Management mit Vernetzung zu Systempartnern aus Bildungs- und Sozialwesen notwendig.
Multiple Sklerose und COVID-19
Authors: Guger Michael , Traxler Gerhard 
Published: January 2021

ZusammenfassungAlter, Behinderungsgrad, Übergewicht und Komorbiditäten sind bekannte Risikofaktoren für den schweren Verlauf einer COVID-19-Erkrankung bei Patienten mit multipler Sklerose. Die Diagnose einer multiplen Sklerose per se stellt, nach aktuellem Wissensstand, jedoch keinen isolierten Faktor für eine Ansteckungsgefahr oder einen schweren Verlauf dar. Ebenso wird die Fortführung krankheitsmodifizierender Therapien aufgrund der bisherigen Erfahrungen als sicher und ohne generell erhöhtes Risiko für die Patienten erachtet. Eine bereits etablierte Therapie bei multipler Sklerose sollte daher auch trotz COVID-19-Pandemie fortgeführt werden. Bei Patienten mit entsprechender Indikation sollte die Einleitung einer Therapie nicht verzögert werden. Weitere Auswertungen zukünftiger Registerdaten zur Bestätigung der bisherigen Ergebnisse sind wünschenswert und notwendig.
Analysis of entrapped and free liquor to gain new insights into kraft pulping
Authors: Brännvall Elisabet , Rönnols Jerk 
Published: January 2021

AbstractMost of our knowledge on kraft pulping comes from studies on dissolved lignin in the freely drainable black liquor and isolated residual lignin in pulp. However, entrapped liquor in the delignified chips has been shown to differ significantly from the free liquor. The present study has compared three liquor fractions: free, lumen and fiber wall liquor. The free liquor was obtained by draining the delignified chips, the lumen liquor was separated by centrifugation and the fiber wall liquor by subsequent leaching. The liquor in the fiber wall had the lowest concentration of lignin and hydrosulfide ions and the highest concentration of monovalent cations. The dissolved lignin in the fiber wall liquor had the highest molar mass and the highest content of xylan. The highest concentration of dissolved lignin was in the liquor filling the lumen cavities. The lignin in the free liquor had the lowest molar mass and the lowest content of lignin structures containing β-O-4 linkages and aliphatic hydroxyl groups. The lowest mass transfer rate of dissolved lignin was from the lumen liquor to the free liquor probably restricted by the tortuosity of the chip.
The Final Act: An Ethical Analysis of Pia Dijkstra’s Euthanasia for a Completed Life
Authors: Holzman T. J. 
Published: January 2021

AbstractAmongst other countries, the Netherlands currently allows euthanasia, provided the physician performing the procedure adheres to a strict set of requirements. In 2016, Second Chamber member Pia Dijkstra submitted a law proposal which would also allow euthanasia without the reason necessarily having any medical foundation; euthanasia on the basis of a completed life. The debate on this topic has been ongoing for over two decades, but this law proposal has made the discussion much more immediate and concrete. This paper considers the moral permissibility of Pia Dijkstra’s law proposal, focusing on the ethics of the implementation Dijkstra describes in her proposal. I argue that, at present, Dijkstra’s law proposal is unsuitable for implementation, due to a number of as of yet unaddressed problems, including the possible development of an ageist stigma and undue pressure on the profession of end-of-life coordinator. Perhaps adequate responses can be conceived to address these issues. However, the existence of a radically different, yet currently equally unacceptable position regarding the implementation of euthanasia for a completed life as proposed by fellow party member Paul Schnabel suggests it may be difficult to formulate an ethically acceptable implementation for this, in principle, ethically acceptable concept.
A Pre-registered Meta-analysis Based on Three Empirical Studies Reveals No Association Between Prenatal (Amniotic) Cortisol Exposure and Fluctuating Asymmetry in Human Infants
Authors: Bushell Will , Heil Martin , Ventura Teresa , Gomes Manuel C. , Körner Lisa M. , Lawrenz Judith , Schaal Nora K. , Richards Gareth 
Published: January 2021

AbstractDevelopmental instability (DI) reflects an organism’s inability to develop an ideal phenotype when challenged by genetic and environmental insults. DI can be estimated via the proxy measure of fluctuating asymmetry (FA), i.e., the small random deviations from perfect bilateral symmetry observed in the morphology of paired traits. The mechanisms involved in the genesis of FA in human populations are relatively unknown, though animal research indicates that hormonal processes may be involved. As maternal stress during pregnancy is detrimental to various developmental processes, elevated prenatal cortisol may represent a causal factor in the subsequent emergence of an asymmetrical phenotype. The main purpose of this pre-registered meta-analysis based on three empirical studies was to investigate whether mid-trimester amniotic cortisol levels predict subsequent FA in finger lengths of infants from Germany, Portugal, and the UK. No statistically significant relationships were observed, and meta-analytic combination of the effect size estimates yielded a null result. We did, however, detect significant positive correlations between the cortisol present in the amniotic fluid and maternal plasma in the Portuguese cohort, and observed that FA in the German cohort was significantly lower at 70-months than at either 9- or 20-months. Taken together, the current findings run contrary to animal research showing that elevated prenatal corticosterone exposure leads to increased FA. However, this may be because a single cortisol assay obtained via amniocentesis is an inadequate proxy for average gestational exposure, and/or that prenatal cortisol levels at an earlier (i.e., first rather than second trimester) stage of pregnancy is what explains variance in subsequent FA.
Cell Sources for Human In vitro Bone Models
Authors: Ansari Sana , Ito Keita , Hofmann Sandra 
Published: January 2021

AbstractPurpose of ReviewOne aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient’s own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the appropriate cell sources for development of such models.Recent FindingsBone marrow and peripheral blood are considered as suitable sources for extraction of osteoblast/osteocyte and osteoclast progenitor cells. Recent studies on these cell sources have shown no significant differences between isolated progenitor cells. However, various parameters such as medium composition affect the cell’s proliferation and differentiation potential which could make the peripheral blood-derived stem cells superior to the ones from bone marrow.SummaryPeripheral blood can be considered a suitable source for osteoblast/osteocyte and osteoclast progenitor cells, being less invasive for the patient. However, more investigations are needed focusing on extraction and differentiation of both cell types from the same donor sample of peripheral blood.
A Survey on Advancing the DBMS Query Optimizer: Cardinality Estimation, Cost Model, and Plan Enumeration
Authors: Lan Hai , Bao Zhifeng , Peng Yuwei 
Published: January 2021

AbstractQuery optimizer is at the heart of the database systems. Cost-based optimizer studied in this paper is adopted in almost all current database systems. A cost-based optimizer introduces a plan enumeration algorithm to find a (sub)plan, and then uses a cost model to obtain the cost of that plan, and selects the plan with the lowest cost. In the cost model, cardinality, the number of tuples through an operator, plays a crucial role. Due to the inaccuracy in cardinality estimation, errors in cost model, and the huge plan space, the optimizer cannot find the optimal execution plan for a complex query in a reasonable time. In this paper, we first deeply study the causes behind the limitations above. Next, we review the techniques used to improve the quality of the three key components in the cost-based optimizer, cardinality estimation, cost model, and plan enumeration. We also provide our insights on the future directions for each of the above aspects.
Annealing effects on structural and photovoltaic properties of the dip-SILAR-prepared bismuth oxyhalides (BiOI, Bi7O9I3, Bi5O7I) films
Authors: Matiur R. MD , Abuelwafa A. A. , Putri Anissa A. , Kato S. , Kishi N. , Soga T. 
Published: January 2021

AbstractBismuth oxyhalides are becoming a promising contender for photovoltaic applications due to its non-toxic nature and decent optical properties. This study mainly deals with clarifying the effects of phase transformations on the structure, optical, and electrical properties of BiOI thin film prepared via dip-successive ionic layer adsorption and reaction (SILAR) method at different annealing temperatures ranging from 100 to 400 °C. Therefore, significant phase transformations (i.e., the existence of Bi7O9I3 and Bi5O7I have been confirmed at 300 °C and 400 °C, respectively) appeared in the produced films, which were mainly due to the change of annealing temperatures. The experimental results confirmed that produced films achieved the maximum current density and efficiency and minimum current density and efficiency at 100 °C and 400 °C, respectively. Experimental results were also showed that with increasing the annealing temperature from 100 to 400 °C, the indirect bandgap risen from 1.77 to 2.96 eV while the crystallite size decreased from 17.62 to 12.99 nm. The energy band diagram with electrolyte explained the observed poor electrical properties during the phase transformation. Hence, this result will add positive impacts on the new information on findings for the dip-SILAR-prepared BiOI photovoltaic cells.
The Urban Mask Layer as Reference Geometry for Spatial Planning: Moving from German to European Geodata
Authors: Schumacher Ulrich 
Published: January 2021

AbstractIn view of rising urbanisation around the world, it is vital to improve the analysis and evaluation of spatial settlement structures in order to ensure the sustainable design of associated transformation processes. Geodata and the maps derived from urban datasets can contribute significantly to understanding the characteristics of settlement structures. In this context, urban areas with a concentration of settlement elements form an important reference geometry. In Germany, such an urban mask is termed Ortslage and is included as an object type in the official topographical basic geodata (ATKIS). It would be useful to have a similar urban mask at European level, especially as a layer of the Urban Atlas within the framework of the Copernicus Land Monitoring Service. Here we present a GIS-supported algorithm to generate such a layer from Urban Atlas data. The method is demonstrated on 30 European cities showing a wide range of urban structures. Further, we compare the physical shape of the Ortslage with the urban mask, here illustrated by the city of Leipzig, Germany. As a basic example of the planning relevance of this method, we consider and discuss the metric shape complexity of the urban space for the cartographic comparison of cities. Furthermore, we address the question of a mixed automated-manual technology in the delineation of the urban mask. The regular updating of the Urban Atlas data within the framework of the Copernicus Land Monitoring Service opens up the possibility of integrating analyses based on the urban masks into the European Spatial Observation.
A new Hardy–Mulholland-type inequality with a mixed kernel
Authors: Rassias Michael Th. , Yang Bicheng , Raigorodskii Andrei 
Published: January 2021

AbstractBy the use of weight coefficients and techniques of real analysis, we establish a new Hardy–Mulholland-type inequality with a mixed kernel and a best possible constant factor in terms of the hypergeometric function. Equivalent forms, an operator expression with the norm and reverses are also considered.
Effect of Stepped Care on Sexual Interest and Enjoyment in Distressed Patients with Head and Neck Cancer: A Randomized Controlled Trial
Authors: Schutte Laura E.R. , Melissant Heleen C. , Jansen Femke , Lissenberg-Witte Birgit I. , Leemans C. René , Sprangers Mirjam A.G. , Vergeer Marije R. , Verdonck-de Leeuw Irma M. , Laan Ellen T.M. 
Published: January 2021

Abstract

Introduction
A recent randomized controlled trial (RCT) in patients with head and neck cancer (HNC) with psychological distress showed that a stepped care (SC) program targeting psychological distress compared with care as usual (CAU), is (cost)effective in reducing psychological distress.

Aim
The aim of the present study was to investigate whether SC can coalleviate problems with sexual interest and enjoyment. A secondary aim was to investigate whether the presence of an unmet sexual health need and having a psychiatric disorder (depression or anxiety) at baseline moderated any effect of SC on these sexual variables until 1-year follow-up.

Methods
HNC survivors (N = 134), randomized to SC or CAU, were assessed regarding their sexual interest and enjoyment before and after the intervention and at 3, 6, 9, and 12 months follow-up. Linear mixed models were used to evaluate differences in the course of sexual interest and enjoyment between SC and CAU.

Main Outcome Measure
The “sexuality” symptom subscale, part of the European Organization for Research and Treatment of Cancer, Quality of Life Questionnaire, Head and Neck Cancer–specific module.

Results
Of all patients, 76.1% had an unmet sexual need at baseline, 24.6% had a psychiatric disorder (anxiety or depression). SC did not reduce problems with sexual interest and enjoyment at any of the follow-up measurements compared with CAU (P = .85). This was neither moderated by an unmet sexual health need at baseline (P = .64) nor by the presence of a psychiatric disorder at baseline (P = .59).

Conclusion
A substantial number of patients with HNC have unmet sexual health needs. SC targeting psychological distress does not reduce problems with sexuality in these patients. Interventions specifically targeting sexuality are recommended.
CEO Transformational Leadership and Corporate Entrepreneurship in China
Authors: Pan Yaotian , Verbeke Alain , Yuan Wenlong 
Published: January 2021

ABSTRACTA chief executive officer (CEO) acting as the firm's transformational leader is typically viewed as instrumental to corporate entrepreneurship in established firms, but how exactly does a higher level of corporate entrepreneurship come about, given a transformational CEO's actions? We suggest that organizational ambidexterity can function as a core mediating mechanism between transformational CEOs and the observed level of corporate entrepreneurship and that the effectiveness of this mediating process varies as a function of critical contingencies related to characteristics of the top management team (TMT), the environment and the organization's design. Our empirical evidence, based on a sample of 145 Chinese private sector firms, and using three primary sources of data (145 CEOs, 506 TMT members, and 1,981 middle managers), provides support for a moderated mediation process. We find that the mediating pathway from transformational leadership to corporate entrepreneurship through organizational ambidexterity is not significant when boundary conditions are ignored. However, when environmental dynamism, TMT collectivism, and structural differentiation are included as moderators, CEO transformational leadership does affect corporate entrepreneurship via the creation and effective functioning of organizational ambidexterity.
“Democracy and National Unity Day” in Turkey: the invention of a new national holiday
Authors: Solomonovich Nadav 
Published: January 2021

AbstractOn the night of July 15, 2016, the Republic of Turkey experienced yet another military coup attempt. However, this attempt failed, mainly due to civilian protest and casualties. Their sacrifice, according to the Turkish state, led to the creation of a new national celebration in Turkey, the “Democracy and National Unity Day.” Following the growing interest of historians in the field of national celebrations, this paper examines the creation of this holiday. It argues that the AKP government used this new holiday to shape the Turkish collective national memory and to introduce a national celebration that does not revolve around the founder of the Turkish Republic, Mustafa Kemal Atatürk, who symbolizes the secular camp in Turkey, but rather around the Justice and Development Party government and its more traditional and religious ideology, in the guise of celebrating Turkish democracy.
How to improve infectious disease prediction by integrating environmental data: an application of a novel ensemble analysis strategy to predict HFMD
Authors: Tao Junwen , Ma Yue , Zhuang Xuefei , Lv Qiang , Liu Yaqiong , Zhang Tao , Yin Fei 
Published: January 2021

Abstract
This study proposed a novel ensemble analysis strategy to improve hand, foot and mouth disease (HFMD) prediction by integrating environmental data. The approach began by establishing a vector autoregressive model (VAR). Then, a dynamic Bayesian networks (DBN) model was used for variable selection of environmental factors. Finally, a VAR model with constraints (CVAR) was established for predicting the incidence of HFMD in Chengdu city from 2011 to 2017. DBN showed that temperature was related to HFMD at lags 1 and 2. Humidity, wind speed, sunshine, PM10, SO2 and NO2 were related to HFMD at lag 2. Compared with the autoregressive integrated moving average model with external variables (ARIMAX), the CVAR model had a higher coefficient of determination (R2, average difference: + 2.11%; t = 6.2051, P = 0.0003 < 0.05), a lower root mean-squared error (−24.88%; t = −5.2898, P = 0.0007 < 0.05) and a lower mean absolute percentage error (−16.69%; t = −4.3647, P = 0.0024 < 0.05). The accuracy of predicting the time-series shape was 88.16% for the CVAR model and 86.41% for ARIMAX. The CVAR model performed better in terms of variable selection, model interpretation and prediction. Therefore, it could be used by health authorities to identify potential HFMD outbreaks and develop disease control measures.
Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity
Authors: Schulz André , Deuter Christian E. , Breden Ion-Hideo , Vögele Claus , Wingenfeld Katja , Otte Christian , Kuehl Linn K. 
Published: January 2021

AbstractAcute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic–pituitary–adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE.