bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROJECT SUCCESS: ROLE OF ORGANISATION STRENGTHS AND PROJECT MANAGEMENT COMPETENCIES
Authors: Ayyaz Samman , Khan Rao Aamir , Aslam Sohail , Khushnood Muhammad , Manzoor Humera 
Published: May 2021

Purpose of the study: This research examines the major organisation strength factors, important project management competencies, and the criteria for project success, and their interrelationship.
Methodology: A mixed-method approach is applied with a positivist stance to test the validity of the proposed hypotheses. Based on the detailed literature review and five expert interviews, 'organisation strengths' are identified and classified into three subcategories, making a second-order construct. A survey strategy is used to collect data from PMO individuals of construction organisations. SmartPLS software is used to analyse 97 responses.
Main Findings: The results of this study support the proposed relationship. It suggests that organisation strengths influence project management competencies and project success. Furthermore, resources and capabilities influence project success. The findings are in line with the literature suggesting that organisation resources and capabilities are important for project success.
Application of the study: This study is relevant for PMO individuals, especially in construction organisations. The findings highlight the importance of organisational strengths that lead to build project management competencies and eventually attain project success. These organisational strengths are of great significance to both the researchers and industry practitioners.
The originality of the study: This study has applied a mixed-method approach. The model in the study empirically tests the organisation strength factors affecting project success. Furthermore, the study used SmartPLS software to test the influence of organisation strength to increase project management competencies and their cumulative effect on project success.
Evaluation of the Protective Effect of The Cup Therapy on the Epileptic Seizure in Rats
Authors: ÇETİNKAYA Ayhan , FİDAN Esra , GÖKSU Selim , BOZAT Bihter , DEMİR Serif 
Published: May 2021

Objective: Cup therapy has an important place in traditional and complementary medicine applications. The purpose of our study, this is the first time to investigate the protective effect of cup therapy in rats on experimentally generated epileptic seizures in new rat modeling created by different anatomic regions.
Methods: In our study, 42 Wistar albino rats 3-4 months old (200-250 g) were used. Four other groups (n=7) except G3 and G4, 24 hours after cup therapy application, PTZ (35 mg/kg, sc., 0.2 cc) was injected, followed by behavioral epilepsy scoring.
Results: In the 'Open Area' and 'Elevated Plus Maze' tests, there was no behavioral difference between the cup therapy group and the control group (p > 0.05). Given all the parameters, the G4 group significantly reduces the seizure compared to other groups (p < 0.05). There is a significant difference in G2, G5 and G6 groups compared to G3 in the phases parameter (p < 0.05).
Conclusions: In this study, the new wet cup therapy (G2), which was applied for the first time, had a protective effect on seizures. G2, G5 and G6 groups are observed to suppress seizures compared to G3. Our findings are expected to contribute greatly to animal model analysis in the future.
Библиотека манастира Каленић и Ризница Епархије шумадијске
Authors: Димитријевић Нада 
Published: May 2021

У раду је представљена најстарија рукописна и штампана културна заоставштина манастира Каленић. Истраживањем које је спроведено у оквиру заједничког пројекта Архијерејског намесништва беличког и Народне библиотеке у Јагодини, Оживљавање прошлости за будућност – рукописне и старе штампане књиге на територији Поморавског округа, утврђено је да се у манастиру Каленић чува изузетно вредно књижно наслеђе Поморавља.У порти манастира смештена је Библиотека и Ризница Епархије шумадијске. Највреднији део фонда библиотеке манастира Каленић представља Фонд старих богослужбених књига у коме се чува 29 књига које, на основу Закона о старој и реткој библиотечкој грађи, испуњавају услове да се прогласе за културна добра од изузетног или великог значаја.Ризница Епархије шумадијске чува највредније експонате богослужбених реликвија са простора Епархије шумадијске. Изузетно богатство Ризнице чине рукописне и старе штампане богослужбене књиге.
OPTIMASI DAN ESTIMASI BIAYA PENAMBANGAN DAN PENGOLAHAN BATUBARA DI PT BHUMI RANTAU ENERGI
Authors: Ramadhani M. Faisal , Nurhakim Nurhakim , Hakim Romla Noor 
Published: May 2021

PT Bhumi Rantau Energi (PT BRE) pada Bulan Agustus menargetkan peningkatan produktivitas dari 500 ton per jam menjadi 560 ton per jam. Untuk itu diperlukan evaluasi terhadap ketersediaan umpan, kemampuan pengolahan batubara dan pemuatan batubara produk. Belum adanya referensi biaya pada target baru untuk Pit Cendana Selatan Seam O membuat perlunya estimasi biaya, agar diketahui biaya per-ton pada penambangan batubara (coal getting) dan peremukan batubara (coal crushing). Estimasi biaya yang digunakan ada dua macam, yakni biaya kepemilikan (owning cost) dan biaya operasi (operating cost).Metode yang digunakan dalam penelitian ini adalah menghitung produktivitas aktual alat mekanis kemudian menganalisanya. Supaya mendapat hasil maksimal, maka diperlukan optimasi untuk menghasilkan target yang diinginkan. Setelah dibuat simulasi untuk kegiatan optimasinya, selanjutnya dilakukan perhitungan trial, dimana setelah trial hasilnya akan dianalisis apakah mencapai target atau tidak. Setelah kegiatan trial mencapai target, akan dilakukan perhitungan estimasi biaya pada kegiatan penambangan batubara dan peremukan batubara.Pada trial, didapatkan produktivitas alat gali muat pada fleet 1 sebesar 291,376 ton/jam dan fleet 2 sebesar 290,926 ton/jam, dengan produktivitas Pit 583,302 ton/jam. Produktivitas alat umpan pada StockROM unit WL-01 sebesar 577,949 ton/jam. Produktivitas alat gali muat pada Stockcrushed unit WL-02 sebesar 284,598 ton/jam dan pada WL-03 sebesar 284,234 ton/jam, dengan produktivitas Stockcrushed 569,832 ton/jam. Estimasi biaya pada kegiatan coal getting didapat sebesar $ 0,707/ton dan pada kegiatan peremukan batubara (coal crushing) didapat estimasi sebesar $ 0,287/ton. Kata Kunci : Optimasi, Produktivitas, Estimasi Biaya
STUDI PENGOLAHAN MINERAL ZIRCON (ZrO²) MENJADI ZIRCONIA PADA PT KALIMANTAN ZIRCON INDUSTRI DI DESA GOHONG KECAMATAN KAHAYAN HILIR KABUPATEN PULANG PISAU PROVINSI KALIMANTAN TENGAH
Authors: Abbas Abbas , Triantoro Agus , Riswan Riswan 
Published: May 2021

PT Kalimantan Zircon Industri menargetkan produksi konsentrat zircon sebanyak 80 ton per hari melalui proses pengolahan gravity konsentrat dengan menggunakan meja goyang, magnetik seperation dan elektrostatis separation pada shif siang mulai pukul (07.00 – 16.00 WIB) dan shif malam (16.00 – 01.00 WIB ).Pada kegiatan penelitian ini dilakukan dengan melakukan pengamatan secara langsung di lapangan dan mengkompilasi data tersebut dengan literatur berdasarkan teori yang berkaitan dengan pengolahan bahan galian khususnya mineral zircon menjadi zirconia dengan kadar 65,6 % sebagaimana sudah di atur dalam Peraturan Menteri Energi dan Sumber Daya Mineral Nomor 7 Tahun 2012 tanggal 6 Februari 2012, mengamanatkan bahwa pelaku usaha yang bergelut di bidang pengolahan mineral zircon diwajibkan melakukan peningkatan nilai tambah mineral melaui pengolahan dan pemurnian dengan kadar mineral zirconia berupa produk akhir 65,6 %, rangkaian proses pengolahan ini dimulai dari pengolahan pada sluice box, meja goyang, magnetik seperation dan elektrostatis separation dan pengulangan pengolahan pada pada sluice box, meja goyang, magnetik seperation dan elektrostatis separation serta mengkaitkan pengaruh kecepatan air tipis pada permukaan meja goyang dan peningkatan feed dalam pencapaian target produksi 80 ton per hari dan menganalisa hubungan pencapaian target produksi tersebut dengan feed, material balance dan recovery.Dari hasil penelitian, sebanyak 86 ton material pasir zircon diperlukan untuk mendapatkan konsentrat zirconia 81,8 ton per hari dengan kecepatan feed 2,384 kg/m, recovery 76,3 %, kecepatan aliran tipis air pada permukaan meja goyang 3,164 m/s, dan volume fluida 48,675 m/s. Kata-kata kunci: zircon, konsentrat, feed, produksi
ANALISIS PENGARUH CURAH HUJAN TERHADAP PARAMETER KUALITAS BATUBARA PADA SEAM 12 MAWAR DI STOCK ROM MALINTUT PT MULTI TAMBANGJAYA UTAMA
Authors: Winda Winda , Triantoro Agus , Annisa Annisa 
Published: May 2021

Permasalahan yang timbul dari parameter kualitas batubara ini adalah hujan yang sering melanda pit atau stock ROM mengakibatkan kualitas batubara tidak stabil sehingga perlu diadakannya penanganan kualitas batubara. Lokasi kegiatan di PT Multi Tambangjaya Utama di Kabupaten Barito Selatan, Provinsi Kaliantan Selatan.Pada penelitian ini, melakukan sampling sebelum hujan dan ± 12 jam setelah hujan dan menganalisis sampel batubara dilaboratorium data – data yang didapat adalah nilai total moisture, inherent moisture, ash content, volatile matter, total sulfur, calori value, serta menganalisa faktor – faktor yang mempengaruhi pengurangan parameter kualitas batubara setelah hujan.Data hasil parameter kualitas batubara yang dianalisis adalah sebelum hujan: 1007 %TM 8.57 (ar), %IM 3.94 (adb), %ASH 5.45 (adb), %VM 45.35 (adb), %FC 45.26 (adb), %TS 3.23 (adb), CV 6913 kcal/kg (ar).Data hasil parameter kualitas batubara setelah hujan adalah : 1507 %TM 7.02 (ar) karena cuaca panas dan sampel dalam keadaan kering, 2208 %TM 10.81 (ar) karena cuaca gerimis selama 75 menit dan sampel dalam keadaan lembab, 2907 %IM 4.47 (adb), 3207 %IM 3.66 (adb) karena proses equilibrium (pengoksidian sampel pada suhu dan kelembaban ruang uji) di laboratorium yang kurang stabil, 2907 %ASH 6.87 (adb), 2208 %ASH 3.92 (adb) karena proses pencucian secara alami yang disebabkan oleh hujan, 2707 %VM 42.83 (adb), 2208 %VM 45.60 (adb) karena karena total moisture naik, 2907 %TS 3.79 (adb), 2108 %TS 2.96 (adb), karena pencucian alami yang disebabkan oleh hujan sulfur yang dimaksud pyritic sulfur, 1507 CV 7096 kcal/kg (ar), 2208 CV 6702 kcal/kg (ar) karena semakin tinggi moisture dan abu, semakin kecil nilai kalorinya. Kata kunci: kualitas batubara, pengaruh hujan, stock ROM
KAJIAN TEKNIS KETIDAKSESUAIAN ANTARA RENCANA PENAMBANGAN DENGAN KONDISI AKTUAL DI TAMBANG BATUBARA PT SENAMAS ENERGINDO MINERAL SITE JAWETEN, KABUPATEN BARITO TIMUR, PROVINSI KALIMANTAN TENGAH
Authors: Kusmana Evanrio , Santoso Eko , Novianti Yuniar Siska 
Published: May 2021

Dalam Kegiatan Penambangan sering terjadi adanya ketidaksesuaian antara rencana dengan kondisi aktual dilapangan dimana target waktu kerja dan target produksi mengalami ketidaksesuaian jika tidak didentifikasi secara dini, ketidaksesuian ini dapat terjadi berulang dan berlanjut setiap bulan, dan akan berpotensi menyebabkan kerugian terhadap perusahaan. Penelitian ini dilakukan dengan mengumpulkan data primer dan sekunder memakai dua cara, yaitu pengamatan lapangan dan penggunaan data perusahaan. Pengolahan data dilakukan dengan melakukan perhitungan volume overburden tergali dari data survey dan membandingkannya dengan target perencanaan terjadwal sehingga mendapatkan faktor-faktor keteidaksesuaian antara perencanaan dan aktual produksi. Analisis pembahasan dilakukan dengan cara mengkorelasikan hasil pengolahan data dengan masalah yang diteliti. Berdasarkan ketidaksesuaian target waktu kerja dan aktual produksi ketidaksesuaian alat gali EC750DL (1) sebesar 87%, EC750DL (2) sebesar 86%, dan EC950Lc (3) sebesar 81%. Ketidaksesuaian untuk target produksi alat gali EC750DL (1) sebesar 90%, EC750DL (2) sebesar 89%, dan EC950Lc (3) sebesar 77%. Berdasarkan hasil survey untuk target februari sebesar 222,927.11 BCM ketidaksesuaian 77,86%, dengan penggalian melebihi elevasi 51,503.04 BCM dan sisa penggalian 186,134.26 BCM. Berdasarkan hasil produksi sebesar 246,696.00 BCM ketidaksesuaian sebesar 86.17%. Dengan upaya peningkatan produksi sebesar 268,986.00 BCM dengan ketidaksesuaian sebesar 93.95%. Kata Kunci: ketidaksesuaian, target produksi, aktual produksi, survey
Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
Authors: Pinkard Otis , Mcfarland Sean , Sweet Thomas , Coller Jeff 
Published: May 2021

Abstract
Transfer RNAs (tRNA) are quintessential in deciphering the genetic code; disseminating nucleic acid triplets into correct amino acid identity. While this decoding function is clear, an emerging theme is that tRNA abundance and functionality can powerfully impact protein production rate, folding, activity, and messenger RNA stability. Importantly, however, the expression pattern of tRNAs is obliquely known. Here we present Quantitative Mature tRNA sequencing (QuantM-tRNA seq), a technique to monitor tRNA abundance and sequence variants secondary to RNA modifications. With QuantM-tRNA seq we assess the tRNA transcriptome in mammalian tissues. We observe dramatic distinctions in isodecoder expression and known tRNA modifications between tissues. Remarkably, despite dramatic changes in tRNA isodecoder gene expression, the overall anticodon pool of each tRNA family is similar across tissues. These findings suggest that while anticodon pools appear to be buffered via an unknown mechanism, underlying transcriptomic and epitranscriptomic differences suggest a more complex tRNA regulatory landscape.
Sample preparation and imaging procedures for super-resolution microscopy using Repeat DNA-PAINT.
Authors: Clowsley Alexander H , Kaufhold William T , Lutz Tobias , Meletiou Anna , Michele Lorenzo Di , Soeller Christian 
Published: May 2021

Abstract
The performance of DNA-PAINT in biological samples is often constrained by strong background signals and non-specific binding events, both of which are exacerbated by high imager concentrations. Here we describe the procedure for conducting Repeat Domain DNA-PAINT, a method that substantially reduces imager concentration and thus suppresses spurious signals.
Sharpness Recognition Based on Synergy between Bio-inspired Nociceptors and Tactile Mechanoreceptors&nbsp;
Authors: Parvizi-Fard Adel , Salimi-Nezhad Nima , Amiri Mahmood , Falotico Egidio , Laschi Cecilia 
Published: May 2021

Abstract
Touch and pain sensations are complementary aspects of daily life that convey crucial information about the environment while also providing protection to our body. Technological advancements in prosthesis design and control mechanisms assist amputees to regain lost function but often they have no meaningful tactile feedback or perception. In the present study, we propose a bio-inspired tactile system with a population of 23 digital afferents: 12 RA-I, 6 SA-I, and 5 nociceptors. Indeed, the functional concept of the nociceptor is implemented on the FPGA for the first time. One of the main features of biological tactile afferents is that their distal axon branches in the skin, creating complex receptive fields. Given these physiological observations, the bio-inspired afferents are randomly connected to the several neighboring mechanoreceptors with different weights to form their own receptive field. To test the performance of the proposed neuromorphic chip in sharpness detection, a robotic system with three-degree of freedom equipped with the tactile sensor indents the 3D-printed objects. Spike responses of the biomimetic afferents are then collected for analysis by rate and temporal coding algorithms. In this way, the impact of the innervation mechanism and collaboration of afferents and nociceptors on sharpness recognition are investigated. Our findings suggest that the synergy between sensory afferents and nociceptors conveys more information about tactile stimuli which in turn leads to the robustness of the proposed neuromorphic system against damage to the taxels or afferents. Moreover, it is illustrated that spiking activity of the biomimetic nociceptors is amplified as the sharpness increases which can be considered as a feedback mechanism for prosthesis protection. This neuromorphic approach advances the development of prosthesis to include the sensory feedback and to distinguish innocuous (non-painful) and noxious (painful) stimuli.
Large Scale Synthesis of Native Turn and Helix Mimics Stabilized by a Generic Hydrogen Bond Surrogate
Authors: Prabhakaran Erode N , Pal Sunit , Kumar Ankur , Mahajan Shifali 
Published: May 2021

Abstract
Short Turn and Helix mimics frequently represent molecular recognition surfaces perturbing bio-relevant protein-biomolecular interfaces. Generic methods that can stabilize short peptides into turns or helices by retaining all recognition elements, have tremendous applications in drug discovery. Here, a versatile modular synthetic protocol is presented for stabilizing turns and helices of different sizes by replacing their ring-closing hydrogen bonds with a generic three-carbon covalent surrogate. Two Fukuyama-Mitsunobu reactions insert the surrogate between desired residues in high yields and purity. Coupling with turn size-dependent oligopeptides containing both sterically restricted and non-coded residues, followed by macrolactamization yield a variety of stabilized turns. Short peptide extensions at the C-terminus of these turns yield stabilized 310-helices and α-helices. This solution-phase synthetic approach provides combinatorial access to libraries of stabilized turns and helices with all their native residues retained, in >100 mmole scales, in about one week per stabilized mimic, to technicians with postgraduate level training.
Dietary Magnesium Intake and its Association with Leukocyte Telomere Length in US Middle-aged and Elderly Adults
Authors: Hu Lihua , Hu Guiping , Bai Yi , Wang Baomin , Bao Huihui , Cheng Xiaoshu , Li Jianping 
Published: May 2021

Abstract
Background: Magnesium supplementation may extend the life span; however, the biological mechanism is still unknown. Leukocyte telomere length (LTL) is a marker of cell aging and biological health in humans. Data concerning whether magnesium supplementation can maintain telomere length, thus prolonging life are limited.Purpose: To investigate the association between dietary magnesium intake and LTL in US middle-aged and elderly adults. Methods: A total of 4039 US adults aged ≥45 years from National Health and Nutrition Examination Survey (NHANES, 1999-2002). Dietary magnesium intake was collected by a trained interviewer using 24-hour dietary recall method and LTL was obtained using the quantitative polymerase chain reaction (PCR) method. Multivariate linear regression analysis was performed to evaluate the the crude and adjusted association of dietary magnesium intake with LTL. Results: The overall mean (SD) of LTL was 5.6 (0.6) kp. After adjusting potential confounders, every 1 mg increase in log-transformed dietary magnesium intake was associated with 0.20 kp [95% confidence intervals (CI): 0.05-0.34] longer LTL. Participants with the highest tertile (≥ 299 mg) of dietary magnesium intake had statistically significant longer LTL (β = 0.07, P=0.038) compared with the lowest tertile (< 198 mg), with significant linear trends across tertiles. Moreover, the association between dietary magnesium intake and LTL was significantly stronger in participants with higher levels of education (≥ high school compared with < high school, P for interaction = 0.002). E-value analysis suggested robustness to unmeasured confounding.Conclusions: Our findings suggested that increased dietary magnesium intake was associated with longer LTL. Theses warrant additional investigation.
Clinical Profile of Migraine Headache Patients: A Descriptive Study of A Single Tertiary Centre in Malaysia
Authors: LAU YUE HUI , Kurien Jessica , LAU KENG MING , Adenan Sufian 
Published: May 2021

Abstract
Background:Migraine is one of the most common disabling neurological disorder among adult population in Malaysia. Purpose:To evaluate demographic characteristics among the migraine patients.Methods:A total of 73 patients with the complain of headache, who aged 18 to 65 were recruited prospectively at neurology clinic from December 2017 to April 2019 in Kuala Lumpur Hospital. All new patients were mainly referred by primary care clinics. Demographic characteristics such as age and gender, age of onset, clinical phenotypes, trigger factors, rescue therapy, prophylaxis usage, frequency of headache, psychiatric symptoms, marital status and education level were all evaluated. Migraine headaches were coded according to ICHD-III criteria. Statistical analysis was analysed using SPSS software. Descriptive statistics, mean and standard deviation were used to evaluate for clinical data.Results:44 out of 73 patients had migraine (60.3%). The mean age of migraine patients was 30 and mean age of onset was 24.8. Majority of the sample were female (36, 81.8%), single (23.52.3%) and with tertiary education level (31, 70.5%). The most frequent symptoms included unilateral headache (36, 81.8%) with throbbing in quality (39, 88.6%). The main trigger factor was stress (23, 52.3%). The most frequently used rescue therapies are sleeping and paracetamol ingestion (18, 40.9%). Most of the patients experienced acute attack 4-14 days in a month (15, 34.1%). 42(95.5%) patients were prophylaxis naïve.ConclusionCharacteristics of the migraine patients in Kuala Lumpur Hospital are comparable with previous studies. A registry of headache patients is crucial to determine the prevalence and local impact of the disease in Malaysia.
Human Adipose Derived Stem Cell Exosomes Enhance the Neural Differentiation of PC12 Cells
Authors: Najafabadi Samira Shariati , Amirpour Noushin , Amini Sharhram , Zare Nasrin , Kazemi Mohammad , Salehi Hossein 
Published: May 2021

Abstract
Background: Human adipose stem cells (hADSCs) are proper cell sources for tissue regeneration. They mainly mediate their therapeutic effects through paracrine factors as exosomes. The exosomes contents are protein, lipid and RNA. Exosomes are effective in restoring the function of neurons and astrocytes in neurodegenerative diseases, and improve the therapeutic outcomes. We investigated the effect of hADSCs derived exosomes on survival and neural differentiation of PC12 cells in vitro.Methods and Results: The isolated hADSCs, were characterized by flow cytometry. Exosomes were separated from hADSC-condition medium using Exo-spinTM kit and characterized by DLS and TEM. Then acridine orange staining was performed to confirm entrance of exosomes into PC12 cells. PC12 cells were treated with culture medium containing NGF and exosome. Cell viability was assessed by MTT assay, and neural differentiation by ICC technique and qRT-PCR. TEM and DLS data confirmed the isolation of exosomes according to their size (30-100nm) and acridine orange staining indicated entrance of exosomes to target cells. MTT assay showed that cell viability was significantly increased in exosome treated group. ICC technique revealed that the expression of Map2 was superior in the exosome treated group. Based on qRT-PCR data, Map2 and β-tub III gene expression was increased in the exosome treated group. Significant expression of Gfap was seen in the NGF and NGF/EXO treated groups.Conclusions: Present study indicated that hADSCs derived exosomes might enhance cell viability and promote neuronal differentiation and expression of mature neural marker in PC12 cells.