bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological interactions between calcium silicate‐based endodontic biomaterials and periodontal ligament stem cells: A systematic review of in vitro studies
Authors: Sanz José Luis , Guerrero‐Gironés Julia , Pecci‐Lloret María P. , Pecci‐Lloret Miguel R. , Melo María 
Published: August 2021

AbstractBackgroundMost recently, the biological interactions, that is cytocompatibility, cell differentiation and mineralization potential, between calcium silicate‐based biomaterials and periodontal ligament stem cells (PDLSCs) have been studied at an in vitro level, in order to predict their clinical behaviour during endodontic procedures involving direct contact with periodontal tissues, namely root canal treatment, endodontic surgery and regenerative endodontic treatment.ObjectiveThe aim of the present systematic review was to present a qualitative synthesis of available in vitro studies assessing the biological interaction of PDLSCs and calcium silicate‐based biomaterials.MethodologyThe present review followed PRISMA 2020 guidelines. An advanced database search was performed in Medline, Scopus, Embase, Web of Science and SciELO on 1 July 2020 and last updated on 22 April 2021. Studies assessing the biological interactions of PDLSCs with calcium silicate‐based sealers (CSSs) and/or cements (CSCs) at an in vitro level were considered for inclusion. The evaluation of the ‘biological interaction’ was defined as any assay or test on the cytotoxicity, cytocompatibility, cell plasticity or differentiation potential, and bioactive properties of PDLSCs cultured in CSC or CSS‐conditioned media. Quality (risk of bias) was assessed using a modified CONSORT checklist for in vitro studies of dental materials.ResultsA total of 20 studies were included for the qualitative synthesis. CSCs and CSSs, as a group of endodontic materials, exhibit adequate cytocompatibility and favour the osteo/cementogenic differentiation and mineralization potential of PDLSCs, as evidenced from the in vitro studies included in the present systematic review.DiscussionThe influence of the compositional differences, inclusion of additives, sample preparation, and varying conditions and manipulations on the biological properties of calcium silicate‐based materials remain a subject for future research.ConclusionsWithin the limitations of the in vitro nature of the included studies, this work supports the potential use of calcium silicate‐based endodontic materials in stem cell therapy and biologically based regenerative endodontic procedures.RegistrationOSF Registries; https://doi.org/10.17605/OSF.IO/SQ9UY.
Solid pancreas transplant outcomes with increased donor and recipient ages compared with reference ages: a systematic review
Authors: Ling Jonathan E. H. , Choo Shi Zhou , Polkinghorne Kevan R. , Kanellis John 
Published: August 2021

AbstractBackgroundIncreased recipient and donor age are associated with worse solid organ pancreas transplant outcomes. However, donor and recipient age criteria vary between jurisdictions. We systematically reviewed studies reporting the association between transplanting older recipients and donors beyond current Transplantation Society of Australia and New Zealand (TSANZ) limits with solid pancreas transplant outcomes.AimsTo review current outcomes of solid pancreas transplantation in recipients and donors over the TSANZ reference ages.MethodsStudies comparing transplant outcomes between a reference‐age and an older‐age donor (>45 years) or recipient (≥50 years) cohort for solid pancreas transplantation were included. Primary outcomes were pancreas/kidney graft and patient survival at 1 and 5 years. Secondary outcomes were post‐transplant complications (graft thrombosis, acute rejection and relaparotomy rates).ResultsEleven studies were included (two studies assessing solid pancreas outcomes between older vs reference‐aged donors and nine studies assessing outcomes between older vs reference‐aged recipients). Seven of 11 studies were judged to be at high risk of bias. Primary and secondary outcomes were not significantly different between recipient age groups in nine studies. A sensitivity analysis of older versus reference‐aged studies excluding studies at high risk of bias also showed non‐inferior primary and secondary outcomes at 1 year. Two studies comparing outcomes by donor age showed worse graft survival but non‐inferior patient survival with older donors.ConclusionIncreased donor or recipient age alone should not absolutely contraindicate solid pancreas transplantation, especially if other risk predictors are minimised.
Outcomes following parathyroidectomy for secondary hyperparathyroidism in patients with chronic kidney disease: a single‐centre study
Authors: Bali Parul , Toussaint Nigel D. , Tiong Mark K. , Ruderman Irene 
Published: August 2021

AbstractBackgroundSurgical parathyroidectomy may be required for severe and refractory secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD). Parathyroidectomy is associated with long‐term survival benefit despite an increase in short‐term morbidity and mortality. Global variation in practice exists, with limited Australian data on outcomes following parathyroidectomy.AimTo evaluate clinical outcomes of patients with chronic kidney disease undergoing surgical parathyroidectomy for secondary hyperparathyroidism.MethodsWe conducted a retrospective study of patients who underwent parathyroidectomy for SHPT between January 2010 and December 2019 at a single tertiary referral centre in Melbourne, Australia. Biochemical markers and medications were assessed 12 months pre‐ and post‐surgery. Clinical outcomes, including hospital readmission, cardiovascular events and mortality were assessed following surgery.ResultsDuring the 10‐year study period, 129 patients underwent parathyroidectomy for SHPT (mean age 50.7 ± 15 years; 109 (85%) on dialysis). Significant immediate post‐operative complications were seen in eight (6%) patients, requiring admission to the intensive care unit (n = 6) or return to theatre (n = 2). Within the first 6 months, 24 (19%) patients required hospital readmission. Within 12 months post‐parathyroidectomy, 100 (78%) and 103 (80%) patients experienced at least one episode of hypercalcaemia (corrected calcium >2.6 mmol/L) or hypocalcaemia (corrected calcium <2.1 mmol/L) respectively. Over a 12‐month period, there were six (5%) deaths and eight (6%) patients experienced a major cardiovascular event.ConclusionSignificant fluctuations in serum calcium levels are common post‐parathyroidectomy; however, long‐term morbidity and mortality in our cohort were lower than previously reported, highlighting that parathyroidectomy in a carefully selected cohort is safe for severe SHPT refractory to medical treatment.
Analysing triggers for anti‐NMDA‐receptor encephalitis including herpes simplex virus encephalitis and ovarian teratoma: results from the Queensland Autoimmune Encephalitis cohort
Authors: Swayne Andrew , Warren Nicola , Prain Kerri , Gillis David , Wong Richard , Blum Stefan 
Published: August 2021

AbstractBackgroundAnti‐N‐methyl‐D‐aspartate‐receptor (anti‐NMDA‐R) encephalitis is a complex autoimmune neuropsychiatric syndrome. Although initially associated with ovarian teratoma, subsequent studies have demonstrated that anti‐NMDA‐R encephalitis may occur without an identifiable cause or be triggered by viral infection of the central nervous system such as herpes simplex virus encephalitis (HSVE).AimTo present details from a Queensland cohort analysing triggering events in patients with anti‐NMDA‐R encephalitis in an Australian context.MethodologyThe authors identified patients with anti‐NMDA‐R encephalitis diagnosed and managed through public hospitals in Queensland, Australia, between 2010 and the end of 2019. Data collected included demographics, clinical presentation, investigation results, management and outcome measurements.ResultsThirty‐one cases of anti‐NMDA‐R encephalitis were included in the study. Three cases of anti‐NMDA‐R encephalitis were triggered by prior HSVE, five cases were associated with ovarian teratoma and 23 cases had no identifiable trigger. There were an additional three cases in which anti‐NMDA receptor antibodies were present in the context of other disease states but where the patient did not develop anti‐NMDA‐R encephalitis. Cases triggered by HSVE or associated with ovarian teratoma experienced a more severe disease course compared to cases with no identifiable trigger. All groups responded to immunosuppressive or immunomodulatory therapy. Analysis of clinical characteristics revealed a complex heterogeneous syndrome with some variability between groups.ConclusionIn this cohort, the number of cases of anti‐NMDA‐R encephalitis triggered by HSVE is comparable to those triggered by ovarian teratoma. However, the majority of cases of anti‐NMDA‐R encephalitis had no identifiable trigger or associated disease process.
Plasma cell survival: The intrinsic drivers, migratory signals, and extrinsic regulators
Authors: Nguyen Doan C. , Duan Meixue , Ali Mohammad , Ley Ariel , Sanz Ignacio , Lee F. Eun‐Hyung 
Published: August 2021

SummaryAntibody‐secreting cells (ASC) are the effectors of protective humoral immunity and the only cell type that produces antibodies or immunoglobulins in mammals. In addition to their formidable capacity to secrete massive quantities of proteins, ASC are terminally differentiated and have unique features to become long‐lived plasma cells (LLPC). Upon antigen encounter, B cells are activated through a complex multistep process to undergo fundamental morphological, subcellular, and molecular transformation to become an efficient protein factory with lifelong potential. The ASC survival potential is determined by factors at the time of induction, capacity to migration from induction to survival sites, and ability to mature in the specialized bone marrow microenvironments. In the past decade, considerable progress has been made in identifying factors regulating ASC longevity. Here, we review the intrinsic drivers, trafficking signals, and extrinsic regulators with particular focus on how they impact the survival potential to become a LLPC.
PTCSC3‐mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation
Authors: Jiang Bo , Chen Yong , Xia Fada , Li Xinying 
Published: August 2021

AbstractThe Warburg effect (aerobic glycolysis), a hallmark of cancer, serves as a promising target for diagnosis and therapy. Growing evidence indicates that long non‐coding RNAs (lncRNAs) play an important role in aerobic glycolysis of various tumours. However, the correlation between lncRNAs and glycolysis in thyroid cancer cells is still poorly understood. In this study, we showed that lncRNA papillary thyroid cancer susceptibility candidate 3 (PTCSC3) was significantly downregulated in papillary thyroid carcinoma (PTC). Overexpression of PTCSC3 significantly inhibited the aerobic glycolysis and tumour growth of PTC cells. Consistently, PTCSC3 overexpression suppressed tumour progress in vivo. Mechanistically, PTCSC3 inhibits aerobic glycolysis and proliferation of PTC by directly interacting with PGK1, a key enzyme in glycolytic pathway. As a result, PTCSC3 performs its role in PTC development via PGK1 and may be a potential therapeutic target for PTC treatment.
Effect of periodontal–orthodontic treatment of teeth with pathological tooth flaring, drifting, and elongation in patients with severe periodontitis: A systematic review with meta‐analysis
Authors: Papageorgiou Spyridon N. , Antonoglou Georgios N. , Michelogiannakis Dimitrios , Kakali Lydia , Eliades Theodore , Madianos Phoebus 
Published: July 2021

AbstractAimTo assess the beneficial and adverse effects on the dental and periodontal issues of periodontal–orthodontic treatment of teeth with pathological tooth flaring, drifting, and elongation in patients with severe periodontitis.Materials and methodsNine databases were searched in April 2020 for randomized/non‐randomized clinical studies. After duplicate study selection, data extraction, and risk‐of‐bias assessment, random‐effect meta‐analyses of mean differences (MDs) and their 95% confidence intervals (CIs) were performed, followed by subgroup/meta‐regression analyses.ResultsA total of 30 randomized and non‐randomized clinical studies including 914 patients (29.7% male; mean age 43.4 years) were identified. Orthodontic treatment of pathologically migrated teeth was associated with clinical attachment gain (−0.24 mm; seven studies), pocket probing depth reduction (−0.23 mm; seven studies), marginal bone gain (−0.36 mm; seven studies), and papilla height gain (−1.42 mm; two studies) without considerable adverse effects, while patient sex, gingival phenotype, baseline disease severity, interval between periodontal and orthodontic treatment, and orthodontic treatment duration affected the results. Greater marginal bone level gains were seen by additional circumferential fiberotomy (two studies; MD = –0.98 mm; 95% CI = –1.87 to −0.10 mm; p = .03), but the quality of evidence was low.ConclusionsLimited evidence of poor quality indicates that orthodontic treatment might be associated with small improvements of periodontal parameters, which do not seem to affect prognosis, but more research is needed.
Equity Short Selling and the Bank Loan Market
Authors: Ho Po‐Hsin , Lin Chih‐Yung , Lin Tse‐Chun 
Published: August 2021

AbstractUsing a difference‐in‐differences approach, we show that relaxation of short‐sale constraints helps to filter out low‐quality borrowers from the bank loan market. Treated firms that can still borrow from banks enjoy a lower loan spread, compared with control firms without this sorting mechanism. The results show that such treated borrowers have improved information asymmetry and credit risk, as well as better nonprice contract terms. Overall, equity short selling has a real effect on the bank loan market by weeding out poor‐quality borrowers, resulting in a lower cost of private debt for remaining borrower firms.
Contextualizing Management Research: An Open Systems Perspective
Authors: Filatotchev Igor , Ireland R. Duane , Stahl Günter K. 
Published: August 2021

AbstractManagement researchers rely frequently on theoretical perspectives originating in North American and European contexts. Given the influences context has on scholarship, the question becomes if using primarily Western theories provides researchers with the design insights needed to capture the robust context of the setting in which they conduct their studies. Herein, we seek to establish a foundation for developing fertile exchanges of ideas regarding contextualized management research. To do this, we examine some of the main theories in management studies through the heuristic lens of an ‘open systems’ framework that allows us to build on comparative management and institutional theories. We discuss existing theory advances in selected areas of management studies, including corporate governance, strategic management, entrepreneurship, and corporate social responsibility (CSR) to offer avenues for future research. Completing studies with a solid grounding in contextualized management theories has the potential to provide novel research avenues and opportunities to integrate diverse theoretical perspectives. We also identify a need for multidisciplinary research, epistemological openness, and methodological pluralism.
A novel melatonin‐regulated lncRNA suppresses TPA‐induced oral cancer cell motility through replenishing PRUNE2 expression
Authors: Su Shih‐Chi , Yeh Chia‐Ming , Lin Chiao‐Wen , Hsieh Yi‐Hsien , Chuang Chun‐Yi , Tang Chih‐Hsin , Lee Yi‐Chan , Yang Shun‐Fa 
Published: August 2021

AbstractThe inhibitory effect of melatonin on cancer cell dissemination is well established, yet the functional involvement of lncRNAs in melatonin signaling remains poorly understood. In this study, we identified a melatonin‐attenuated lncRNA acting as a potential melatonin‐regulated oral cancer stimulator (MROS‐1). Downregulation of MROS‐1 by melatonin suppressed TPA‐induced oral cancer migration through replenishing the protein expression of prune homolog 2 (PRUNE2), which functioned as a tumor suppressor in oral cancer. Melatonin‐mediated MROS‐1/PRUNE2 expression and cell motility in oral cancer were regulated largely through the activation of JAK‐STAT pathway. In addition, MROS‐1, preferentially localized in the nuclei, promoted oral cancer migration in an epigenetic mechanism in which it modulates PRUNE2 expression by interacting with a member of the DNA methylation machinery, DNA methyltransferase 3A (DNMT3A). Higher methylation levels of PRUNE2 promoter were associated with nodal metastases and inversely correlated with PRUNE2 expression in head and neck cancer. Collectively, these findings suggest that MROS‐1, serving as a functional mediator of melatonin signaling, could predispose patients with oral cancer to metastasize and may be implicated as a potential target for antimetastatic therapies.
The role of prior sleep for divergent thinking in infants
Authors: Seehagen Sabine , Charlton Samuel , Starkey Nicola , Fallaize Amy , Brown Juliana , Jones Kelly 
Published: August 2021

SummaryHigher‐order cognitive functions seem particularly vulnerable to disruptions in prior sleep in school‐aged children and adult populations. This study tested whether divergent thinking in infants varied as a function of prior sleep. Forty‐three infants aged 13–16 months participated in a behavioural assessment of divergent thinking. Length of wakefulness since last sleep was experimentally manipulated. In addition, potential relations between divergent thinking and sleep quantity and quality during the night immediately before the assessment, as well as during three consecutive nights preceding the assessment, were examined using actigraphy recordings in combination with parent diaries. Divergent thinking was not impaired by lack of sleep within the previous 4 h. Divergent thinking was consistently related to night‐time sleep quality and quantity prior to the assessment. These results suggest that timing of prior naturally occurring daytime sleep is less relevant for emergent divergent thinking capacity than quality and quantity of preceding night‐time sleep.
The changing characteristics of patients infected with chronic hepatitis C virus from 2014 to 2019: Real‐world data from the German Hepatitis C‐Registry (DHC‐R)
Authors: Hüppe Dietrich , Stoehr Albrecht , Buggisch Peter , Mauss Stefan , Klinker Hartwig , Teuber Gerlinde , Hidde Dennis , Lohmann Kristina , Bondin Mark , Wedemeyer Heiner 
Published: August 2021

AbstractThe number of patients diagnosed with hepatitis C virus (HCV) is markedly higher than the number initiating treatment indicating gaps in the care cascade, likely centred around reaching at‐risk populations. Understanding changing characteristics of patients with HCV allows for targeted programs that increase linkage to care. We investigated changes in demographic and clinical characteristics of patients registered in the German Hepatitis C‐Registry (DHC‐R) from 1 January 2014 to 31 December 2019. The DHC‐R is an ongoing, noninterventional, multicentre, prospective, observational cohort registry including 327 German centres. Patient characteristics were analysed over time in 7 phases for all patients completing a screening visit. Overall, 14,357 patients were enrolled. The percentage of treatment‐naïve/non‐cirrhotic patients increased from 34.4% in phase 1 (1 January–31 December 2014) to 68.2% in phase 7 (1 August–31 December 2019). The proportion of migrants, alcohol users, people who inject drugs, and those receiving opiate substitution therapy increased in later registry phases. Most patients (60.1%) were receiving comedication at baseline. The most prescribed comedications were drugs used to treat opioid dependence which increased from 9.2% in phase 1 to 24.0% in phase 7. The patients’ mean age decreased from 52.3 years in phase 1 to 48.7 years in phase 7. From 2014 to 2019, the proportion of at‐risk patients enrolling in the registry increased. To eliminate viral hepatitis as a major public health threat, a continued commitment to engaging underserved populations into the HCV care cascade is needed.
The Rgg1518 transcriptional regulator is a necessary facet of sugar metabolism and virulence in Streptococcus pneumoniae
Authors: Shlla Bushra , Gazioglu Ozcan , Shafeeq Sulman , Manzoor Irfan , Kuipers Oscar P. , Ulijasz Andrew , Hiller N. Luisa , Andrew Peter W. , Yesilkaya Hasan 
Published: July 2021

AbstractRggs are a group of transcriptional regulators with diverse roles in metabolism and virulence. Here, we present work on the Rgg1518/SHP1518 quorum sensing system of Streptococcus pneumoniae. The activity of Rgg1518 is induced by its cognate peptide, SHP1518. In vitro analysis showed that the Rgg1518 system is active in conditions rich in galactose and mannose, key nutrients during nasopharyngeal colonization. Rgg1518 expression is highly induced in the presence of these sugars and its isogenic mutant is attenuated in growth on galactose and mannose. When compared with other Rgg systems, Rgg1518 has the largest regulon on galactose. On galactose it controls up‐ or downregulation of a functionally diverse set of genes involved in galactose metabolism, capsule biosynthesis, iron metabolism, protein translation, as well as other metabolic functions, acting mainly as a repressor of gene expression. Rgg1518 is a repressor of capsule biosynthesis, and binds directly to the capsule regulatory region. Comparison with other Rggs revealed inter‐regulatory interactions among Rggs. Finally, the rgg1518 mutant is attenuated in colonization and virulence in a mouse model of colonization and pneumonia. We conclude that Rgg1518 is a virulence determinant that contributes to a regulatory network composed of multiple Rgg systems.
The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish
Authors: Lu Youyou , Zhang Junxue , Zhou Xiaohong , Guan Meiyu , Zhang Zhe , Liang Xi , Tong Lingjun , Yi Huaxi , Gong Pimin , Bai Lu , Zhou Hui , Liu Tongjie , Zhang Lanwei 
Published: August 2021

AbstractBackgroundConstipation is a gastrointestinal symptom with high incidence rate and large number of patients. It is becoming one of the urgent medical problems. Poor intestinal motility is one of the important causes of constipation. Current drug treatments for constipation are associated with many side effects; thus, it is necessary to study more effective treatment methods and potential mechanism.MethodsA zebrafish model of intestinal motility obstruction was established by loperamide hydrochloride to evaluate the effect of probiotic, food ingredients, and combination on intestinal peristalsis according to intestinal peristalsis frequency counts. The gastrointestinal survival ability of the best probiotics was evaluated by surface hydrophobicity, self‐aggregation, acid and bile salt tolerance, and gastrointestinal transit tolerance. Interactions between probiotics and food ingredients were studied in vivo and in vitro. The expression of 5‐HT was detected by ELISA and fluorescence immunoassay, and 5‐HT related genes were detected by RT‐PCR.Key ResultsWe obtained the probiotics, food ingredients, and combination that effectively promoted intestinal peristalsis, X11 and YRL577, P. persica and KGM, KGM + X11, respectively. Both KGM and P. persica promoted colonization of probiotics in vivo. KGM + X11 could effectively promote the increase in 5‐HT synthesis in zebrafish via up‐regulating gene expression of TPH‐1, TPH‐2, and 5‐HTR and down‐regulating gene expression of SERT. The specific in‐depth mechanism needs further study.Conclusions and InferencesThe combinations of KGM with X11 effectively promoted intestinal peristalsis. We provide a theoretical basis for new modalities that can promote intestinal peristalsis and alleviate constipation.