bluuebunny/crossref_metadata_2025_split huggingface dataset:
The improvement of cardiac multispiral computed tomography protocol for planning interventional arrhythmia management
Authors: Kashtanova N. Yu. , Kondratyev E. V. , Karmazanovsky G. G. , Gruzdev I. S. , Artyukhina E. A. , Yashkov M. V. , Revishvili A. Sh. 
Published: May 2021

Purpose. Comparison of computer tomography (СT) contrast enhancement (CE) protocols for optimal visualization of cardiac chamber, definition it’s influence on results of non-invasive superficial cardiac mapping.Materials and methods. The study included 93 patients with heart rhythm disorders who planned catheter ablation of arrhythmia. Noninvasive cardiac mapping was made for topical diagnostics. It includes multichannel ECG-registration and CT with intravenous СE (1st group monophasic (50 patients), 2nd group split-bolus (18 patients), 3rd group with pre-bolus (25 patients). Qualitative and quantitative (measurement of mean blood attenuation in four chambers, calculation of ventricular-myocardial contrast-to-noise ratio VM-LV и VM-RV for left ventricle (LV) and right ventricle (RV), respectively) parameters were compared between groups. Fusion of ECG and CT data was made semi-automatic with diagnostic complex «Amycard 01К».Results. Regardless of CE technique was noted sufficient and homogeneous contrast attenuation of left atrium (LA) and LV (mean blood attenuation in LA more than 278 HU, LV 250 HU, VM-LV 0,582). Enhancement of right heart was insufficient with monophasic protocol, in most cases the average CT density was lower than 200 HU, VM-RV 0,256. Split-bolus protocol improves visualization of right atrium (RA) and RV (blood density in RA 258HU, RV 227HU, VM-RV 0,541), however there was heterogeneity of RA cavity because of artifacts from superior vena cava (VC) and unenhanced blood from inferior inferior VC. Using of pre-bolus increases contrast ratio between RA myocardium and blood due to increasing CT density of blood in inferior VC (blood density 294 HU). Quality of right ventricle CE was similar to 2nd group (blood density 264 HU, VM-RV 0,565).Conclusion. CE protocols split-bolus and with pre-bolus improve visualization of right ventricle, supporting the high level enhancement of left heart. Protocol with pre-bolus is preferable for exact differentiation of right atrial endocardial contour.
Beat-to-beat blood pressure measurement in patients with atrial fibrillation: a step towards personalized managemen
Authors: Shubik V. V. , Pivovarov V. V. , Zaytsev G. K. , Korneev A. B. , Tihonenko V. M. , Kormilitsyn A. Y. , Gordeeva M. V. , Berman M. V. , Lobov G. I. , Bondarev S. А. , Usov A. A. 
Published: May 2021

Aim. Blood pressure (BP) determination in atrial fibrillation (AF) patients remains challenging due to its high inter-measurement variability. The novel methodology of precise beat-to-beat BP determination may be used to guide the hypotensive therapy selection and adjustment, but along with that provides additional opportunity for the investigation of hemodynamics in patients with chronic AF.Material and method. The study sample consisted of 60 patients with the main diagnosis of grade II-III arterial hypertension; 30 of those were on sinus rhythm and 30 had chronic non-valvular AF. In all patients HR was within the limits recommended for left ventricular ejection fraction of >40%. Beat-to-beat systolic, diastolic, and pulse BP (SBP, DBP, and PBP, respectively) assessment at each heart beat within 15 minute interval was performed with “Kardiotekhnika-SAKR” system (NAO “Incart”, St.Petersburg, Russia).
The role of high-density mapping in atrial fibrillation ablation
Authors: Dedukh E. V. , Artyukhina E. A. 
Published: May 2021

Aims. To determine the role of the prevalence of low-voltage areas in the occurrence of arrhythmia recurrence after interventional treatment of atrial fibrillation (AF).Methods. The study included 38 patients with paroxysmal (52.6%) and persistent (47.4%) forms of AF who underwent interventional treatment of AF using high-density electroanatomical mapping (at least 10,000 EGM points). Analysis of electroanatomical maps was performed after the completion of the ablation procedure. The area of the low-voltage zones was measured manually. Then, the areas of all regions of low-voltage activity were summed up; the resulting value was expressed as a percentage of the total surface area of the left atrium (LA).Results. The observation period was 12.8±3.2 months. Based on the results of endocardial mapping, all patients were divided into 2 groups according to the prevalence of low-voltage areas in the LA. The first group included patients with an area of low-voltage zones less than 5% of the total surface of the left atrium, and the second with an area of low-voltage areas of more than 5% of the total surface of the left atrium. The patients of the first group had a lower LA volume compared to patients from the second group, with mean values of 119.87±16.35 ml and 154.57±33.23 ml, respectively (p=0.007). In the first group, AF recurrence was recorded in one patient after catheter treatment, in the second group in 5 patients.Conclusion. Common areas of low-voltage activity in the left atrium, detected by high-density mapping before the procedure for catheter treatment of AF, are a predictor of arrhythmia recurrence after interventional treatment.
Autonomic nervous modulation after cryoballoon ablation for paroxysmal atrial fibrillation
Authors: Novikov I. A. , Novikov P. S. , Mironov N. U. , Shariya M. A. , Sokolov S. F. , Maykov E. B. 
Published: May 2021

Aim. Aim of our study was the assessment of autonomic nervous system (ANS) modulation by assessment of heart rhythm variation (HRV) using Holter monitoring after single second generation cryoballoon ablation (CBA) for paroxysmal atrial fibrillation (AF).Methods. Patients who underwent the CBA for paroxysmal AF were include in this study. At the baseline the Holter monitoring after withdrawal of antiarrhythmic therapy (AAT) with assessment of HRV: SDNN, RMSSD, ln LF, ln LH, LH/HF, mean, minimal and maximal beats per minute (BPM) was perform. Follow-up was based on outpatient clinic visits at 3, 6, and 12 months including Holter monitoring.Results. Among 80 patients underwent CBA, HRV was assessed in 55 patients (65.5% male, age median 61 years, 97.7% of pulmonary vein have been successful isolated). One year after CBA all HRV parameters and the mean, minimal and maximal BPM was significantly different from baseline parameters (p<0.05). In the AF recurrence group ln LF was lower at 3-, 6and 12-month visits (p<0.05) and minimal HR was higher at 3 months (median 58 vs 55.5, p=0.033). Multivariate analysis demonstrated that early recurrence of AF was independent predictor of AF recurrence after CBA (HR 7,44, 95% CI 2,19-25,25, р=0,001).Conclusion. Our study demonstrated that CBA leads to modulation of ANS which persists for at least 12 months. The early recurrence of AF was only predictor of AF recurrence after CBA.
Acute effects of laser myocardial ablation in <i>ex vivo</i> and <i>in vivo</i>
Authors: Condori Leandro Н. I. , Vakhrushev A. D. , Korobchenko L. E. , Koshevaya E. G. , Mitrofanova L. B. , Goncharova N. S. , Andreeva E. M. , Mikhaylov E. N. , Lebedev D. S. 
Published: May 2021

Aim. To study and compare the lesions characteristics of laser energy in heart ex vivo and in experimental large animals.Materials and methods. For the ex vivo experiment a pig heart was obtained from a local slaughterhouse. Laser applications were applied using power 15-30 W in the left and right ventricles 5-50 seconds in duration. Immediately after ablation, examination was performed to determine myocardial damage characteristics at each point. In the experimental study, 7 sheep were included, laser applications were performed under fluoroscopic control in the right atrium with power 10, 15 and 20 W, 10-25 s; in the right ventricle 20, 25 and 30 W for 10-40 s; and in the left ventricle 20, 25 and 30 W for 20-40 s. The animals were euthanized and macroscopic examination of laser lesions was performed.Results. A total of 27 laser applications were performed on the heart ex vivo, all lesions were visualized as white spots on the endocardial surface. The maximum lesion depth was 9 mm achieved when using 20 W /50 s, the maximum lesion diameter was 6 mm, when using 25 W /40 s. The minimum lesion diameter and depth were observed when using 30 W /5 s, 2x1 mm. A total of 48 laser applications were performed in experimental animals, in one experimental animal was observed a transmural lesion in the right atrium when using 15 W /20 s. In 3 out of 7 experimental animals, transmural lesions were observed in the right ventricle when using 20 W /30 s; 20 W /40 s and 30 W /10 s. In the left ventricle, transmural lesions were observed in 2 animals, using 15 W /20 s and 20 W /40 s. In the ex vivo study, there was a strong positive correlation between ablation energy and lesion depth (R=0.91, P<0.05) and lesion volume (R=0.73, P<0.05); while there was no such statistical correlation in vivo.Conclusions. Laser ablation 15-20 W for 15-40 s seems to be optimal for achieving the deepest lesions in the atrium and ventricular myocardium. In our small pilot study with fiberoptic catheter ablation on a beating heart there was no correlation between energy delivered and the depth and volume of necrotic myocardium.
Experimental use of stereotactic radiosurgery for non-invasive interventions in arrhythmology
Authors: Vaskovskiy V. A. , Taymasova I. A. , Kalinin D. V. , Antipina N. A. , Nikolaeva A. A. , Smirnov G. Y. , Golanov A. V. , Potapov A. A. , Revishvili A. Sh. 
Published: May 2021

Purpose. The aim of the experimental study was to study the effects of stereotaxic radioablation of various doses on the myocardium of the atria, ventricles and atrioventricular (AV) node in the long term (up to 6 months); as well as assessment of collateral damage during radioablation.Material and methods. The research was carried out on 4 domestic pigs. The animals were 10-12 weeks old, the average weight was 30±2.7 kg. Linear accelerator «TrueBeam», Varian was used for the experiment. Animals were divided into groups according to the zones of planned radiation exposure: 1st animal AV node (dose 35 Gy), 2nd animal AV node and the apex of the left ventricle (LV) (dose 40/35 Gy, respectively), 3rd animal pulmonary veins (PV) and left atrium (dose 30 Gy), 4th AV node and free wall of the LV (dose 45/40 Gy). Under intravenous sedation with hemodynamic monitoring, contrast-based CT of the heart was performed to assess the degree of displacement of the heart chambers in one respiratory and cardiac cycle and to assess the anatomy of the chambers of the heart and adjacent organs. The allocation and the contouring of the target zones were carried out in 3 projections: axial, frontal and sagittal. For electrophysiological control, loop recorders were implanted in each animal. The average exposure time was 11±7 minutes. The long-term follow-up period was 6 months, followed by morphological examination of autopsy material.Results. The average follow-up period after the experiment was 134.75±77.34 days. The electrophysiological effect of the ablation was achieved in cases of complete AV-block development. This effect was developed in 2 out of 3 animals, whose AV-node was exposed: 2nd animal 40 Gy on 108th day of observation and 4th animal 45 Gy on 21st day of observation. No cardiac arrhythmias were recorded in all cases. The results of macroand microscopic examination showed significant changes in the target zones. These areas had precise but uneven damage boundaries, which were within the planned ones (conformal exposure with a high degree of precision). The transmural nature of the changes was noted as well. Massive fields of fibrous tissue of various degrees of maturity (with a predominance of subepicardial localization) with focal hemorrhages of various ages and granulations were detected, which were surrounded by cardiomyocytes with coagulated and vacuolated cytoplasm.Conclusion. The use of non-invasive stereotactic treatment of tachyarrhythmias has high prospects in modern arrhythmology as an alternative ablation method.
An Intersectional Investigation of Study Abroad Intent among Latino/a and White First-generation College Students
Authors: Goldstein Susan B. , Lopez Henry N. 
Published: May 2021

Despite a marked increase in study abroad participation in recent decades, first-generation students and Students of Color remain vastly underrepresented. The current study sought to expand the extant literature on first-generation and Latino/a students’ study abroad participation by applying an intersectional approach to identifying predictors of study abroad intent. A total of 478 undergraduates (Latino/a and White; first-generation and continuing-generation) completed a questionnaire based on previously identified predictors of study abroad intent. Separate binary logistic regression analyses for each of the four (ethnicity x generational status) subgroups indicated that personality and intercultural variables predicted intent to study abroad solely for the White continuing-generation students. Exposure to study abroad was a primary predictor of intent across subgroups, yet significant between-group differences emerged regarding the source and extent of this exposure. Implications for study abroad advising and inclusive participation are discussed.
Formulation, Characterization and In vitro Drug Delivery of Vitexin Loaded Liposomes
Authors: Sivathanu Dr.S.Bhagavathy , G Shivapriya , G Shivapriya 
Published: May 2021

Liposome is a spherical vesicle which contains atleast one lipid bilayer. Liposomes are used as a novel drug carriers because of its hydrophobic and hydrophilic nature, it has many advantages in the field of medical sciences. There are some other drug carriers like dendrimers, micelles, niosomes. Out of all, liposomes are considered to be the most promising agent for drug delivery. The uniqueness of liposome is when it is used as a pharmaceutical drug, it acts as a natural receptor. Thus it acts as an antigen and binds with the antibody (cancer cell) without causing any damage to the adjacent cells. For the synthesis of liposomes, a phospholipid is required. The liposomes can be synthesized using egg yolk and chloroform. So the basic phospholipid is obtained from egg yolk. For more stability, the liposomes are prepared using popc. The present work discuss about the effective preparation of drug loaded liposomes using popc (1- palmitoyl-2-oleoyl-sn-glycero-3- phosphocholine). POPC is an important phospholipid for biophysical experiments. Additionally chloroform is used as the solvent for the liposome preparation. The drug chosen for liposome loading is vitexin (vxn), which is an effective therapeutic agent against inflammation and cancer. The vesicular size, shape, drug entrapment efficacy, stability, electrochemical property and drug releasing property of the formulated liposomes were characterized. The results showed that the formulated liposomes are considered as the better drug carrier system and good choice for biotransformation within the cell to reach the target site such as cancer cells. Even though available treatments like chemotherapy and radiation therapy, causes damage to the surrounding cells, the alternative drug transferring system such as liposomal mediated drug transfer within the cell is considered as good choice of treatment to avoid such complications. The aim of liposome mediated drug carrier system is to develop a method to reach the drug to the target site. After drug delivery at the target site, the liposomes are fused within the surface of the body. This is because of the pH of liposomes, which is at 7.4 and temperature is maintained at 37 oC. So, the vxn loaded liposomes are considered as the novel drug carriers for the successful targetted drug delivery.
An In Vitro Study on Inhibiting Pathogenic Activity by Biosynthesized Silver Nanoparticles using Dioscorea Pentaphylla
Authors: N Muniyappan , Murugapandi Murugan 
Published: May 2021

Development of biologically stimulated experimental processes for the biosynthesis of nanoparticles is an essential branch of nanobiotechnology. Biocompatible silver nanoparticles have acknowledged significant notice in recent years because of their capable applications in bioimaging, biosensors, biolabels, and biomedicine. This study reports a green chemistry approach for the biological synthesis of silver nanoparticles by using the rhizomes extract of Dioscorea Pentaphylla. The properties of synthesis nanoparticles were characterized by UV-Visible spectroscopy, FT-IR, SEM, TEM and EDS. Surface Plasmon Resonance (SPR)
spectrum for silver nano-particles is obtained at 426 with dark brown color. FT-IR spectroscopy revealed that silver nanoparticles were functionalized with bio- molecules that have primary amine group (NH2), carbonyl phenolic group (-OH) and other stabilizing functional groups. The Morphological studies revealed that the particles are spherical in shape and in the size ranged from 20 ± 1nm. The effects of silver nanoparticles concentration and extract concentration were investigated and DPR-AgNPs showed the better pharma- cological applications.
Design, Synthesis, Antimicrobial Evaluation and Molecular Docking Studies of Some Novel Monoterpenoids Substituted Quinoxaline Thiosemicarbazide Derivatives
Authors: Bihari Bipin , Gautam Girendra Kumar , Ved Akash 
Published: May 2021

Owing to the increasingly serious problems caused by multidrug resistance in acquired infection pathogens, it has become an urgent need to develop new classes of antibiotics for overcoming the resistance. The present study aims to increase the antimicrobial activity of quinoxaline thiosemicarbazide derivatives by introducing a hydrophobic alkyl chain, an electron-releasing group in the ring, and substitution by some acyclic, cyclic and bicyclic monoterpenes and their antimicrobial evaluation against various strains with molecular docking studies. The lead molecule (1E, 4E)-1-(7-chloro-3-isopropyl- quinoxalin-2(1H)-ylidene) thiosemicarbazide was synthesized and condensed with various monoterpenes to synthesize different derivatives. The structures of compounds were confirmed through IR., NMR & mass spectroscopy. The synthesized derivatives were evaluated in vitro for antibacterial and antifungal activities against various strains using the agar dilution method. Molecular docking studies of the derivatives (Va– Vg) were performed to find out essential binding sites against target protein (PDB: 3 FAP, receptor: FKBP 12) using Autodock 4.2. The compounds Va, Vd, Vf & Vg exhibited potent antibacterial and antifungal activity. Among all these compounds Vd was found to exhibit more potent activity against gram +Ve, gram –Ve bacterial and fungal strains at MIC 0.19 μg/ml, 0.39μg/ml, and 1.56 μg/ml respectively. The docking studies of all the compounds exhibit potent binding energy, but the compound Vd exhibit interactive binding energy (-9.98 kcal/mol) to the active pockets of the receptor FKBP12. The compound Vd interacting with various active sites of amino acids of receptors like PHE128, TRP190, TYR26, VAL55, ILE56, PHE99, and TRP59. In terms of structure- activity relationship study it is revealed that the activity profile against bacterial and fungal strains was altered by the formation of monoterpenoid substituted (1E, 4E)-1-(7- chloro-3-isopropylquinoxalin-2(1H)-ylidene) thiosemicar- bazide derivatives. The study reveals that bicyclic monoterpenes substituted compounds exhibit greater activity than cyclic and acyclic. The molecular docking studies also showed that all the compounds exhibit good docking energy to bind and inhibit the FKBP12 receptor.
Analisis Efektivitas Dan Kontribusi Pajak Reklame Dan Pajak Restoran Terhadap Pendapatan Asli Daerah Kota Bogor
Authors: Yuniati Eka , Yuliandi Yuliandi 
Published: May 2021

Local Revenue is a source of original revenue derived from the potential of the region it self. Local Revenue is often used as an indicator of a region's progress. If the original income of a region is high, the economy of the area is considered advanced. The higher the Local Revenue received, the less dependency between the Regional Government on the Central Government. The largest revenue potential for Local Revenue is generated from local tax collection. One of the potential local tax revenues in Bogor City is the advertisement tax and restaurant tax. The purpose of this study was to determine the level of effectiveness and contribution of advertisement tax and restaurant tax to Local Revenue in Bogor City and to find out the efforts made by the Bogor City Regional Revenue Agency in increasing its local tax revenue. The research method used is descriptive qualitative method.
The result of this research is that the effectiveness of the advertisement tax and restaurant tax collection in Bogor City has been very effective, proven by the average advertisement tax effectiveness ratio of 104.06% and restaurant tax of 103.93%. The contribution of advertisement tax and restaurant tax to Local Revenue in Bogor City is still not good, as evidenced by the average advertisement tax contribution ratio of 1.43% including very poor criteria, and the average restaurant tax contribution of 12.99. % is in the poor criteria. Efforts made by the Bogor City Regional Revenue Agency in increasing advertisement tax revenue and restaurant tax are by collecting taxpayer data, checking tax rates, monitoring tax administration, and building communication and establishing closeness with the community.

Keywords: Effectiveness, Contribution, Advertising Tax, Restaurant Tax, Local Revenue
Pengaruh Biaya Produksi, Biaya Pemasaran, Dan Gaji Karyawan Terhadap Hasil Penjualan
Authors: Pamelda R. Adelya , Pradipto Didit 
Published: May 2021

Pada masa sekarang ini, dimana kemampuan teknologi sudah sangat pesat yang berdampak pada setiap aspek kehidupan tak terlepas dari bidang usaha/bisnis. Persaingan yang amat ketat memaksa tiap perusahaan melakukan dan memberikan yang terbaik untuk para konsumen demi terpenuhinya keinginan konsumen dan tercapainya tujuan perusahaan. Selain itu, strategi terhadap hal yang berpengaruh sangat diperlukan, dalam hal ini penekanan biaya serta pemanfaatan bahan baku, sasaran pasar, serta kemampuan karyawan yang merupakan aset perusahaan menjadi kunci dari sebuah usaha pencapaian tujuan suatu perusahaan.
Tujuan dari penelitian ini adalah mengetahui pengaruh biaya produksi, biaya pemasaran, dan gaji karyawan terhadap hasil penjualan. Populasi dalam penelitian ini adalah data tiap variabel pada CV FahmaHair pada tahun 2017-2019, dalam hal ini didapatkan 36 data dimana data tersebut merupakan total variabel tiap bulannya dan selama 3 tahun (12 bulan X 3 tahun). Penelitian ini menggunakan pendekatan kuantitatif dengan sumber data sekunder. Analisa data menggunakan SPSS 24 dengan metode analisis yaitu analisis statistik deskriptif, uji asumsi klasik, analisis regresi linier berganda, uji t, uji F, dan koefisien determinasi (R2).
Hasil uji t menunjukkan bahwa, variabel biaya produksi memiliki nilai signifikan sebesar 0,000<0,05 atau sig<0,05. Hal tersebut menunjukan bahwa biaya produksi berpengaruh secara signifikan terhadap hasil penjualan. Berbeda dengan variabel biaya pemasaran, dimana nilai signifikan sebesar 0,536>0,05 atau sig>0,05. Hal tersebut menunjukan bahwa biaya pemasaran tidak berpengaruh secara signifikan terhadap hasil penjualan. Variabel gaji karyawan tidak berpengaruh signifikan terhadap hasil penjualan yaitu dengan nilai signifikan sebesar 0,124>0,05 atau sig>0,05. Dari hasil uji F menunjukkan bahwa nilai adjusted R square sebesar 0,874 atau 87,4% yang berarti bahwa biaya produksi, biaya pemasaran dan gaji karyawan mampu mempengaruhi hasil penjualan sebesar 87,4%. Sedangkan sisanya sebesar 12,6% (100%-87,4%) dijelaskan oleh faktor-faktor lain diluar model penelitian ini.

Kata kunci: Biaya produksi, biaya pemasaran, gaji karyawan, penjualan.