bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of a Breastfeeding Support Education Program for Late Preterm Infants: a Randomized Controlled Study
Authors: Sato Izumi , Imura Masumi 
Published: May 2021

Abstract
Background: Nutritional support affects the growth and development of late preterm infants (LPIs) and also impacts their health in the long term. Though breastmilk is the first choice as a nutrition source for LPIs, there is no consensus on how to provide supplements when breastmilk is unavailable, as well as the quantity to be provided or nutritional strategies to be followed. LPIs may need to wait for a certain period until breastmilk supply is sufficient. Nurses and midwives play an important role in supporting the promotion of breastmilk secretion in the postnatal period. Therefore, this study aimed to develop an educational program for them and test its efficacy. Methods: In this two-group parallel randomized controlled trial, the data were collected between July and April 2019 from nurses and midwives working in obstetrics facilities who were randomly assigned to either the breastfeeding support for LPIs (BSLPI) program or the non-technical skills (NTS) program. The effects of the intervention were assessed immediately before, after, and one month after the program. Results: There were 36 participants in the BSLPI group and 33 in the NTS group. The BSLPI group had significantly higher self-efficacy for providing breastfeeding support immediately after (mean=55.7, SD=8.0, p=.001) and one month after the intervention (mean=57.3, SD=8.6, p=.001) compared to immediately before the intervention (mean=47.8, SD=10.3). The BSLPI group demonstrated significant improvements in social skills in nursing interactions with mothers immediately after the intervention (BSLPI: mean=80.5, SD=110.9 vs. NTC: mean=75.0, SD=9.7, p=.032) and one month later (BSLPI: mean=82.5, SD=10.1 vs. NTC: mean=75.8, SD=9.4, p=.010), as well as in knowledge and skills necessary for breastfeeding support for LPIs immediately after the intervention (BSLPI: mean=84.5, SD=8.3 vs. NTC: mean=48.7, SD=11.9, p=.001) and one month later (BSLPI: mean=79.3, SD=11.3 vs. NTC: mean=51.3, SD=12.6, p=.001). Conclusions: The BSLPI intervention increased nurses’ and midwives’ sense of self-efficacy for providing breastfeeding support, social skills in nursing interactions with mothers, and knowledge and skills necessary for breastfeeding support for LPIs, suggesting that it provided effective support. This trial was retrospectively registered with the University Hospital Medical Information Network (UMIN; R000040145UMIN000035227).
Morroniside protect human granulosa cells against H2O2-induced oxidative damage via regulating Nrf2 and MAPK signaling pathway
Authors: Ma Yucong , Hao Guimin , Lin Xiaohua , Zhao Zhiming , Yang Aimin , Cao Yucong , Zhang Shuancheng , Geng Jingran , Fan Lijie , Zhang Yu , Chen Jingwei , He Ming , Du Huilan 
Published: May 2021

Abstract
Background

Morroniside is the main ingredient of Cornus officinalis, which has an antioxidant effect. Ovarian granulosa cells (GCs) are responsible for regulating the development and atresia of follicles, which are susceptible to oxidative stress. In this study, we investigated whether morroniside could inhibit oxidative stress of GCs induced by hydrogen peroxide (H2O2), thus leading to improve oocyte quality.
Methods

The study was divided into 5 groups: control group, H2O2 group, morroniside (5 µM) + H2O2, morroniside (10 µM) + H2O2, Morroniside (20 µM) + H2O2. Cell survival rate was determined by CCK-8, ROS fluorescence level was determined by DCFH-DA probe, MDA, 8-OHdG, T-AOC, SOD, NQO1 and caspase-3 were determined by ELISA, SOD, NQO1, Bax, Bcl-2, caspase-3, caspase-9, Nrf2 and MAPKs protein expression were determined by Western blot, and Nrf2 nuclear translocation level was determined by immunofluorescence method. SPSS21.0 was used for statistical data analysis.
Results

After pretreatment with morroniside, the levels of ROS, MDA and 8-OHdG in ovarian GCs were significantly decreased. Morroniside significantly upregulated the level of p-Nrf2 and promoted the nuclear translocation level of Nrf2, which transcriptionally activated antioxidase SOD and NQO1. In addition, the levels of apoptosis-related proteins Bax, Bcl-2, caspase-3 and caspase-9 were significantly regulated via p38 and JNK pathway by morroniside.
Conclusions

These results suggested that morroniside could reduce oxidative damage and apoptosis of ovarian GCs induced by H2O2 in multiple ways, which provided a new idea for clinical improvement of oxidative stress in female reproductive system.
Regional shifts of crop species diversity in rainfed and irrigated cultivation in Iran
Authors: Jafaria Leila , Asadi Sara , Asgari Ashkan 
Published: May 2021

Abstract
Concerns about the negative effects of declining agricultural biodiversity due to modern agricultural practices and climatic constraints in various parts of the world, including Iran, on the sustainability of agricultural ecosystems are increasingly growing. However, the historical knowledge of temporal and spatial biodiversity is lacking. To identify the value and trend of crop diversity in Iran was used biodiversity indices based on the area under rainfed and irrigated crops and total from 1991 to 2018. The crop species diversity of irrigated cultivation was higher than the rainfed and total cultivations area. The Shannon and Simpson indices had experienced a constant trend, but species richness was increased, which was related to the rise in the area of some species in recent years. The area of wheat and barley had a significant impact on crop diversity so that Shannon diversity was reduced with their dominance. Overall, this study revealed that Iran's agricultural system relies on wheat and barley. We warn that by increasing the area of these crops and the prevalence of monoculture, the probability of damages increased due to external factors such as sudden weather changes or the spread of diseases and the important consequences of which will be instability and production risk in the future.
A Novel Clustering-Based Purity and Distance Imputation for Handling Medical Data With Missing Values
Authors: Cheng Ching-Hsue , Huang Shu-Fen 
Published: May 2021

Abstract
Nowadays, people pay increasing attention to health, and the integrity of medical records has been put into focus. Recently, medical data imputation has become a very active field because medical data usually have missing values. Many imputation methods have been proposed, but many model-based imputation methods such as expectation-maximization and regression-based imputation based on the variables data have a multivariate normal distribution, which assumption can lead to biased results. Sometimes this becomes a bottleneck, such as computationally more complex than model-free methods. Furthermore, directly remove instances with missing values, this approach has several problems, and it is possible to lose the important data, produce ineffective research samples, and cause research deviations, and so on. Therefore, this study proposes a novel clustering-based purity and distance imputation method to improve the handling of missing values. In the experiment, we collected eight different medical datasets to compare the proposed imputation methods with the listed imputation methods with regard to the results of different situations. In imputation measures, the area under the curve (AUC) is used to evaluate the performance of the imbalanced class datasets in MAR and MCAR experiments, and accuracy is applied to measure its performance of the balanced class in MNAR experiment. Finally, the root-mean-square error (RMSE) is also used to compare the proposed and the listing imputation methods. In addition, this study utilized the elbow method and the average silhouette method to find the optimal number of clusters for all datasets. Results showed that the proposed imputation method could improve imputation performance in the accuracy, AUC, and RMSE of different missing degrees and missing types.
Classification of Atrial Fibrillation and Congestive Heart Failure using Convolutional Neural Network with Electrocardiogram
Authors: Fu’adah Yunendah Nur , Lim Ki Moo 
Published: May 2021

Abstract
Delayed diagnosis of atrial fibrillation (AF) and congestive heart failure (CHF) can lead to death. Early diagnosis of these cardiac conditions is possible by manually analyzing electrocardiogram (ECG) signals. However, manual diagnosis is complex, owing to the various characteristics of ECG signals. Several studies have reported promising results using the automatic classification of ECG signals. The performance accuracy needs to be improved considering that an accurate classification system of AF and CHF has the potential to save a patient’s life. An optimal ECG signal classification system for AF and CHF has been proposed in this study using a one-dimensional convolutional neural network (1-D CNN) to improve the performance. A total of 150 datasets of ECG signals were modeled using the1-D CNN. The proposed 1-D CNN algorithm, provided precision values, recall, f1-score, accuracy of 100%, and successfully classified raw data of ECG signals into three conditions, which are normal sinus rhythm (NSR), AF, and CHF. The results showed that the proposed method outperformed the previous methods. This approach can be considered as an adjunct for medical personnel to diagnose AF, CHF, and NSR.
Nutlet Micromorphology and Character Evolution of Some Species of Rochelieae (Boraginaceae) and Its Systematic Implications
Authors: Ebadi Mostafa , Nikzat Sedigheh 
Published: May 2021

Abstract
Background: The macro/micro-morphology of nutlets in 11 species (and 22 accessions) of the Boraginaceae family was investigated by stereomicroscope and scanning electron microscopy to evaluate the taxonomic relevance of these traits. To evaluate the phylogenetic significance of the character evolution, available DNA sequence data from GenBank were combined with selected original nutlet data, and phylogenetic analysis was performed.Results: The Rochelieae nutlets' shape varied from ovoid (ovoid, ovoid-triangular, and ovoid-rectangular) to the pyramid. Six major patterns were recognized based on nutlet ultrastructure characters. Rocheliae is characterized by a transition from “without appendage” to “with tubercles and prickles” on the nutlet disk, and also by a shift from “lack of prickles” to “glossy prickles”.Conclusions: The results indicated that the nutlet ultrastructure pattern of Rochelieae is systematically informative at the genus level, but not at the species level. The results showed that glochid is not an ancestral trait but is a synapomorphy and the transition to this trait occurred in the genus Lappula. The Close boundary of nutlet microstructures between L. barbata and L. microcarpa was discussed.
Constitutive modeling of an electro-magneto-rheological fluid: A continuum mechanics approach
Authors: Kumar Deepak , Sarangi Somnath 
Published: May 2021

Abstract
The present article deals with a continuum mechanics-based method to model an electro-magneto-rheological (EMR) fluid deformation under an electromagnetic field. The proposed method follows the fundamental laws of physics, including the principles of thermodynamics. We start with the general balance laws for mass, linear momentum, angular momentum, energy, and the second law of thermodynamics in the form of Clausius-Duhem inequality with Maxwell’s equations. Then, we derive the generalized constitutive relation for EMR fluids following the representation theorem. To validate of the same, the developed constitutive relation is applied to an electro-rheological fluid valve system. The analytical predictions of the considered system are consistent with the experimentation. At last, we simulate different velocity profiles from the developed constitutive relation in the case of the parallel plate configuration. As a result, we succeed in providing more physics-based analytical findings than the existing studies in the literature.
Minimizing outliers on cardiovascular signals: an open-source solution
Authors: Bazo Gabriel , Silva Taiz Francine Brasil da , Corrêa Fernando Morgan de Aguiar 
Published: May 2021

Abstract
Context: Intravenous cardiovascular recording of conscious animals is susceptible to outlier’s presence, due to freely movement and manipulations. These outliers can interfere on heart rate variability results, indicating erroneous results of sympathetic or parasympathetic modulation.Objective: Develop an automated computational approach to minimize the presence of outliers in cardiovascular recorded signals.Method: An application was developed according to the problem addressed based on free-use web frameworks.Results: The use of the proposed application detected and minimized respectively 1% and 0.97% of points outliers in signals of systolic arterial pressure (SAP) and pulse interval (PI) from a representative blood pressure recording. As until then the work of minimization of outliers was carried out manually; the use of the new application considerably reduced time spend analyzing the data.Conclusion: The proposed algorithm can detect and minimize interferent points, reducing chances of an erroneous interpretation about the cardiovascular modulation by the autonomic nervous system. The method can also significantly reduce the time of manual point-to-point screening performed by researchers.
Impaction of Regurgitation Jet on Anterior Mitral Leaflet Causes Diastolic Dysfunction in Patients With Bicuspid Aortic Valve and Mild Insufficiency: A Cardiovascular Magnetic Resonance Study
Authors: Galea Nicola , Pambianchi Giacomo , Cundari Giulia , Sturla Francesco , Marchitelli Livia , Putotto Carolina , Versacci Paolo , De Paulis Ruggero , Francone Marco , Catalano Carlo 
Published: May 2021

Abstract
Purpose: To assess the impact of regurgitant jet direction on left ventricular function and intraventricular hemodynamics in asymptomatic patients with bicuspid aortic valve (BAV) and mild aortic valve regurgitation (AR), using cardiac magnetic resonance (CMR) feature tracking and 4D flow imaging.Methods: Fifty BAV individuals were retrospectively selected: 15 with mild AR and posterior regurgitation jet (Group-PJ), 15 with regurgitant jet in other directions (Group-nPJ) and 20 with no regurgitation (Controls). CMR protocol included cine steady state free precession (SSFP) sequences and 4D Flow imaging covering the entire left ventricle (LV) cavity and the aortic root. Cine-SSFP images were analyzed to assess LV volumes, longitudinal and circumferential myocardial strain.Results: Circumferential and longitudinal peak diastolic strain rate (PDSR) and peak diastolic velocity (PDV) were reduced in group PJ if compared to group nPJ and control group (PDSR = 1.10±0.2 s-1 vs 1.34±0.5 s-1 vs 1.53±0.3 s-1 , p:0.001 and 0.68±0.2 s-1 vs 1.17±0.2 s-1 vs 1.05±0.4 s-1 ; p<0.001, PDV = -101.6±28.1 deg/s vs -201.4±85.9 deg/s vs - 221.6±67.1 deg/s; p<0.001 and -28.1±8 mm/s vs -38.9±11.1 mm/s vs -43.6±14.3 mm/s, p<0.001, respectively), whereas no differences have been found in systolic strain values. 4D Flow images (available only in 9 patients) showed deformation of diastolic transmitral streamlines direction in group PJ compared to other groups.Conclusion: In BAV patients with AR, the posterior direction of the regurgitant jet may hamper the complete mitral valve opening, disturbing transmitral flow and slowing the LV diastolic filling
Towards an inclusive research culture in upcoming Health and Education Precincts in New South Wales, Australia: implications for policy and practice
Authors: Balasubramanian Madhan , Flood Victoria 
Published: May 2021

Abstract
An inclusive research culture is vital towards the maturity of Health and Education Precincts into an active innovation ecosystem. To date, substantial investments have been made in 13 upcoming Health and Education Precincts in varying stages of development in the Greater Sydney region, New South Wales. The political commitment to create an innovative environment for teaching and a vibrant research culture is noticeable. However, it is unclear to what extent government policy engages the breadth of clinical personnel in teaching and research-related activities and contributes towards improving research culture. Based on a study conducted at the central river district of the Greater Sydney region, we argue that better engagement of clinical personnel in teaching/research-related activities and inclusion of research-related roles within the job description of clinical personnel can substantially drive a positive research culture and thereby contribute towards the overall development of Health and Education Precincts. Opportunities for continued education and training of clinical personnel and involvement in graduate research programs also substantially drives research culture. We argue that future policy and practice solutions for upcoming Health and Education Precincts need to foster an inclusive research culture and should be tailored to meet the needs of an innovative ecosystem. Future solutions will need to contribute towards improving research culture as well as the health and wellbeing of people in the region.
Nanocellulose from citrus processing waste using water and electricity only
Authors: Jitan Samar Al , Scurria Antonino , Albanese Lorenzo , Pagliaro Mario , Meneguzzo Francesco , Zabini Federica , Sakkaf Reem Al , Yusuf Ahmed , Palmisano Giovanni , Ciriminna Rosaria 
Published: May 2021

Abstract
Along with a water-soluble fraction rich in pectin, the hydrodynamic cavitation of citrus processing waste carried out in water directly on a semi-industrial scale affords an insoluble fraction consisting of a new nanocellulose of high quality. Lemon and grapefruit nanocellulose powders isolated upon filtration and mild drying consist, respectively, of 100-500 nm wide cellulose nanorods, and of 500-1,000 nm wide ramified microfibrils extending for several μm. The process is general and can be applied to any citrus processing biowaste. These findings establish a long-sought technically viable route to a material whose numerous potential applications in fields ranging from biomedicine to composite production have been limited by the harsh conditions required for the extraction of nanocellulose via acid or enzymatic hydrolysis following pretreatment of lignocellulosic biomass with acid-chlorite or alkali.
AGAMA, TAKHAYUL DAN KEARIFAN LOKAL DALAM UPAYA PENGEMBANGAN MASYARAKAT BERBASIS PARIWISATA
Authors: Fatkhullah Mukhammad 
Published: May 2021

Abstrak: Dalam pariwisata, eksotisme budaya merupakan daya tarik bagi wisatawan. Akan tetapi, tidak semua budaya menghasilkan dampak yang sama. Beberapa justru menjadi penghambat upaya mengembangan masyarakat, terlebih pada upaya eksplorasi sumberdaya alam potensial untuk menunjang tujuan pembangunan. Penelitian ini bermaksud untuk melihat bagaimana budaya masyarakat lokal memberikan kontribusi pada sektor pariwisata, dengan menggunakan metode eksploratis berdasarkan studi literatur. Hasilnya, budaya masyarakat lokal mampu mendukung sektor pariwisata dengan syarat terdapat unsur kearifan didalamnya. Adapun unsur tersebut dapat bersumber dari Agama, bahkan takhayul sekalipun. Akan tetapi, hal tersebut hanya berlaku pada komunitas yang homogen. Takhayul yang ada pada masyarakat yang heterogen hanya akan menimbulkan keacuhan masyarakat, hingga penelantaran lingkungan. Adapun upaya untuk menghapus takhayul dapat dilakukan melalui peningkatan kualitas pendidikan dan aspek keagamaan. Lebih lanjut, studi ini menemukan bahwa pengembangan wisata berbasis budaya tetap dapat diupayakan dengan mempertimbangkan: (1) regulasi yang beroritentasi pada pengembangan masyarakat dan berwawasan lingkungan, (2) pengembangan yang berfokus pada keunikan dan identitas lokal, serta (3) strategi pemasaran yang menekankan pada pengalaman spiritual.
Kata Kunci: Agama; Takhayul; Kearifan Lokal; Pariwisata; Pengembangan Masyarakat.

Abstract: In the tourism industry, cultural exoticism is an asset that can attract tourists. However, not all cultures offer wisdom. Some become obstacles to community development efforts, especially the exploration of natural resource potentials to support development goals. This study intends to see how the local culture contributes to the tourism sector, using an exploratory method based on literature studies. As a result, the culture of local communities can support the tourism sector if there is an element of wisdom in it. These elements can be derived from religion, even superstition. However, this can only apply if society is homogeneous. A superstition exists in heterogeneous societies that can lead to natural resource neglect or destruction. Efforts to eradicate superstition can be made through improving the quality of education and religious aspects. Furthermore, this study finds that cultural-based tourism development efforts can still be pursued by considering: (1) regulations that are oriented towards community development and sustainable environment, (2) development that focuses on uniqueness and local identity, and (3) marketing strategies emphasize spiritual experiences.
Keywords: Religion; Superstition; Local Wisdom; Tourism; Community Development.
Community-acquired pneumonia in HIV patients
Authors: Viktorova I. B. , Zimina V. N. , Dadyka I. V. , Аndreeva I. V. , Golovina I. A. , Chuzhikova E. P. 
Published: May 2021

The objective: to study the frequency and nature of community-acquired pneumonia (CAP) in HIV patients.Subjects and methods: The continuous longitudinal retrospective study of all cases of respiratory diseases among HIV patients (n = 185), who received in-patient treatment in the therapy department.Results. CAP was diagnosed in 38.4% (n = 71) of patients and it was the most frequent respiratory disease among HIV patients. The median CD4 count in CAP made 197.5 cells/μL, 9.1% of patients received antiretroviral therapy before hospital admission. 74.7% of CAP patients (n = 53) had lesions disseminated to several lobes. Laboratory parameters revealed in severe CAP (leukocytosis > 12 × 109/L, leukopenia < 4.0 × 109/L and thrombocytopenia < 100 × 1012/L) were associated with the degree of immunodeficiency and did not depend on the infiltration dissemination (p > 0.05). Bacteremia in CAP was detected in 20.8% of patients and it was associated with the failure of standard empiric antibiotic therapy (p < 0.05). 9.9% of CAP patients (n = 7) were diagnosed with polymicrobial infection. Lethal outcomes of CAP were recorded in 5.6% of cases (n = 4), all with severe immunosuppression (the median of CD4 count was 5 cells/μL), 2 cases had bilateral subtotal CAP and 2 suffered from polymicrobial infection.
Clinical aspects of using artificial intelligence for the interpretation of chest X-rays
Authors: Morozov S. P. , Kokina D. Yu. , Pavlov N. A. , Kirpichev Yu. S. , Gombolevskiy V. A. , Аndreychenko A. E. 
Published: May 2021

The review considers the possible use of artificial intelligence for the interpretation of chest X-rays by analyzing 45 publications. Experimental and commercial diagnostic systems for pulmonary tuberculosis, pneumonia, neoplasms and other diseases have been analyzed.