bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing Factors Analysis on Provincial Difference of Rural Energy Efficiency in China Employing Super Efficiency SBM Model and Global Malmquist-Luenberger Index
Authors: Wen Lei , Zhou You 
Published: July 2021

Abstract
Given the current circumstance of increasingly severe resource and environmental deterioration, the progress of Chinese rural energy efficiency has a remarkable impression on Chinese future high-quality development. Energy consumption in rural areas accounts for a considerable proportion, so it is imperative to make a specific and accurate assessment of rural energy efficiency. This paper abandons the traditional method of regional division and separates China into eight economic zones. First of all, this paper applies Super-SBM model to calculate the rural energy efficiency and constructs a Global Malmquist-Luenberger (GML) Index based on 2008–2018 panel data. Subsequently, GML is decomposed into technical efficiency change index (GMLEC) and technological progress change index (GMLTC) to analyze green total-factor productivity (GTFP) in rural areas. Eventually, the GML and its decomposition terms of eight economic zones are explained by practicing a cumulative multiplication method from 2008 to 2018. The consequences of employing panel data of region prove that: (1) There is a severe regional imbalance of Chinese rural energy efficiency. (2) The rural energy efficiency in the northwest and southwest (western region) is higher than the Middle Yangtze River and the Middle Yellow River (central region). (3) GMLTC has a significant impact on GTFP.
Antibiotic Resistance Patterns and Distribution of Ampc β-Lactamases Genes Among Acinetobacter Baumannii Clinical Isolates from Hospitals of Tehran, Iran
Authors: Alizadeh Sajad , Baserisalehi Majid , Bahador Nima 
Published: July 2021

Abstract
Background

Acinetobacter is a Gram-negative coccobacilli bacterium that can produce severe and different infections. Among the species of these bacteria, Acinetobacter baumannii is the most common cause of nosocomial infections. Due to the high prevalence of antibiotic resistance in this bacterium and the significant increase in antibiotic resistance, this study was conducted to investigate the antibiotic susceptibility of A. baumannii isolates from Iran. A total of 60 A. baumannii bacteria were isolated from the different clinical samples in hospitals of Tehran, Iran. The isolates susceptibility to 13 commonly used antibiotics was examined according to the Clinical & Laboratory Standards Institute (CLSI) guidelines. Using PCR, three important AmpC β-lactamases relayed genes (DHA, CIT and MOX) were detected.
Results

The highest and lowest resistance rate was related to ampicillin (98.3%) colistin (35%), respectively. Of 60 isolates, 59 isolates (98.34%) were resistant to more than 8 antibiotics. The frequencies of DHA, CIT and MOX genes were 1 (2%), 7 (12%), 27 (46%), respectively. Based on definition, 59 (88.33%), 44 (73.33%) and 13 (21.66%) isolates were MDR, XDR and PDR, respectively. Twenty-four isolates (40%) were negative for all three genes. There was a significant relationship between the presence of MOX gene and antibiotic resistance.
Conclusions

The high resistance rates of the A. baumannii isolates reported in the present study is alarming and need the management of treatment such as performing of antibiogram test before antibiotic therapy for select the appropriate antibiotic and also completes the course of treatment period.
Different Response of Perennial Ryegrass – Epichloë Endophyte Symbiota to the Elevated Concentration of Heavy Metals in Soil
Authors: Żurek Grzegorz , Wiewióra Barbara , Rybka Krystyna , Prokopiuk Kamil 
Published: July 2021

Abstract
The phenomenon of plant mutualistic symbiosis with microbes may have a positive effect on the improvement of plant tolerance to environmental stresses as well as on the ability of plants to accumulate heavy metal (HM) ions from soil. The influence of Epichloë fungal endophyte (Ascomycota, Clavicipitaceae) on perennial ryegrass (Lolium perenne L.) plants grown in the presence of elevated concentrations of HM ions (Cd2+, Pb2+ and Cu2+) in soil was studied. The presence of Epichloë in the host grass tissues resulted in different accumulation of HM ions in the aboveground parts of the plants. In some cases endophyte infection positively affected ryegrass ability to accumulate HM ions from soil. In plants with (E+) and without (E-) endophytes the hormesis effect was induced by the elevated concentration of Cu2+ ions, resulting in better growth and photosynthesis, as examined by measurements of Chl a fluorescence. The obtained results indicate that based on the laboratory evaluation of the efficiency of HM accumulation, we were able to choose the best associations of perennial ryegrass with endophytes for HM phytoremediation.
Small Bowel Obstruction Caused by Tubo-Ovarian Abscess Following Chronic Pelvic Inflammatory Disease: A Case Report
Authors: Li Yanan , Zhang Xiao , Zhao Yaxuan , Zhang Zhiqiang , Meng Li , Du Yanfang , Huang Xianghua 
Published: July 2021

Abstract
BackgroundAlthough there are reports of small bowel obstruction (SBO) secondary to tubo-ovarian abscess (TOA), there have been no documented cases of unexpected SBO, multiple intestinal ruptures and adhesions in a patient with chronic PID followed by successful surgical treatment of TOA who was successfully treated by surgery after failure by conservative treatment.Case presentationA 40-year-old female was admitted with main complaint of abdominal pain and fever for six days. A pelvic mass measuring 6.37x7.85x9.04 cm and ascites at rectovaginal pouch were found despite local treatment with metronidazole and cefazolin. Laboratory tests revealed leukocytosis of 8.9x10^9/L with hyper-neutrocytophilia of 82.8%, C-reactive protein increase at 223 mg/L and Procalcitonin 0.14ng/L. The patient was diagnosed with an acute attack of chronic PID. Tests and body temperature improved after 4 days of IV antibiotics. However, two days later, the patient presented abdominal distension, poor appetite, and difficulty in defecation. Abdominal CT suggested possibility of bowel obstruction. Accordingly, an explorative laparoscopy was performed, revealing 500ml pale yellow ascites within the abdominal cavity. The intestinal tube was clearly dilated with poor peristalsis. Multiple intestinal ruptures and adhesions were found. Dense adhesion existed between the intestinal loop and posterior uterus wall, closing the rectouterine pouch. Pale yellow thick pus could be seen from the end of fallopian tube, and part of the right ovary showed serious pyosis. All the adhesions were split, ruptures were repaired and normal anatomy was restored. Postoperative pathology indicated acute and chronic inflammation of both fallopian tubes with focal abscess formation. The patient was discharged 15 days after operation and followed up at one month without any symptoms.ConclusionIn such cases, close attention should be paid to changes in the patient’s condition and lesion changes. Early laparoscopy is advised when there are significant clinical or CT scan signs of bowel obstruction in TOA patients. Precise predictors or a predictive model for the need of invasive intervention to TOA will require further investigation.
Phenological Plasticity and Adaptive Potential of Sugar Maple Populations
Authors: xiali guo , Buttò Valentina , Surget-Groba Yann , Huang Jian-Guo , Delagrange Sylvain , Rossi Sergio 
Published: July 2021

Abstract
Global changes affect the growing conditions of terrestrial ecosystems, mismatching the phenological adaptation of plants to local climates at mid and high latitudes. Their long lifespan and slow reproductive cycles prevent trees from tracking the quick shift in their usual climatic conditions, thus endangering the survival of local populations. In this study, we explored the phenological plasticity and adaptive potential of bud burst in sugar maple (Acer saccharum Marsh.) seedlings from 30 Canadian origins with contrasting climates planted in two common gardens near and at the northern boundary of the species range. Bud development and leafing occurred in April-May, with complete bud burst lasting between 21 and 29 days. On average, bud swelling differed by 12 days between common gardens. However, this difference decreased to 4 days for complete leafing. Both factors site and seed origin affected bud burst, which represented the phenological plasticity and adaptation of sugar maple, respectively. Overall, the former (7.4–88.3%) contributed more than the latter (9.2–25.5%) to the variance in bud burst, despite the wide climatic range among the provenance origins compared with that at the two common gardens. Adaptation to local conditions provide the genetic tools for the survival of species across wide climatic ranges. Plasticity enables physiological responses of individuals to quick environmental changes. Our study demonstrated the major role of plasticity in bud phenology, and revealed the importance of investing resources in mechanisms dealing with the climatic challenges due to inter-annual variations in weather events.
Level of Oral Hygiene Practices and its Association with Socio-Demographyic Characters Among Middle School Students in Low Income Countries
Authors: Gebregiorgis Tecleab Okubai , Humed Alhassen Saleh , Tekle Beraki Mael , Ghebremedhin Bereket Tesfamichael , Haile Letebrhan Habtemariam 
Published: July 2021

Abstract

Background: The practice of keeping the mouth clean to prevent common oral health diseases is necessary, especially in children who live in developing countries. Thisstudyaims to assess middle school students’ oral hygiene practice (OHP)Status and its association with socio-demographic factors among children in low- income countries in Asmara, Eritrea.Methods: Descriptivecross-sectionalstudy wasconducted to determine the status ofOHPamongMiddle school studentsage of 12-15years. Data was collected from all participants (N=572) through face -to- face interview using a pretested and semi structured questionnaire. Pearson’s chi-square test and multiple binary logistic regressions were usedto analyze the whole data.Results: Overall, majority (70%) of middle school children were having poor OHP.From the total respondents, only 201 (35.2%) of the middleschool children cleaned their teeth two times or more a day,16(3.1%) used dental floss for dental cleaning and 314(54.9%) brushed their teeth after meals.The most utilized oral hygiene tools were toothbrush 554.8(97%), chewstick411.3(71.9%), and toothpick 192 (33.6%).Most of the participants 554(97.4%) used toothpaste during tooth cleaning, but 509 (89%) of the children were unaware about the presence of fluoride in their toothpaste.From the children, 196 (34.4%) changed their brush every three months,and only 72 (12.6%) applied circular strokes while brushing their tooth. The most frequently consumed sugar foods and drinks were bread and biscuits, sugar containing chewing gum and tea cited as 536(93.7%), 256(54.8%) and 486(85%) of the respondents respectively.Around half (52%) of the respondents didn’t cleaning their tongue at all. Only 112 (19.5%) visited a dentist during the past twelve months. OHP score was significantly different for gender and school type (P<0.05).Females children were having better OHP than males AOR=0.636 (0.441 – 0.918, P=0.012).Moreover, Arbate Asmara was less likely to have poor OHP than Bana AOR=0.426 (0.197 – 0.92, P=0.030).Conclusions: This study found that,majority of the children was having poor OHP. Sex and school ofmiddle school children in low income countries had a significantcorrelation with OHP. The results of this study indicatetheneed of a Comprehensive oral hygiene practiceeducation for the children and their parents to achieve good oral hygiene in the middle school.
The Spatial-Temporal Distribution and Control Measures Evaluation of Droplets and Aerosol Cloud in Dental Procedures
Authors: Yuan Chao , Yang Hongtao , Zheng Siyuan , Sun Xiangyu , Chen Xiaochi , Chen Yuntao , Kang Jian , Liu Moubin , Zheng Shuguo 
Published: July 2021

Abstract
Background: Droplets and aerosol cloud generating procedures in dentistry can increase the risk of airborne transmission of diseases such as COVID-19. To gain insight into the diffusion of spatters and possible preventive measures, we measured the particle spatial-temporal distribution characteristic and evaluated the effectiveness of the control measures.Methods: We conducted an experiment to observe the emitted spatters obtained during the simulated dental preparation by using high-speed videography. We measured the particle size distributions by laser diffraction and preliminarily estimated its velocity. We qualitatively and quantitatively described the spatial-temporal distributions of spatters and their control measure effects. Results: Majority of the dental spatters were small droplets (diameter less than 50 μm). A large number of smallest droplets (diameter less than 10 μm) were generated by high-speed air turbine handpiece. At the oral outlet, the speed of large droplets could exceed 2.63 m/s, and the speed of aerosol clouds ranged from 0.31–2.37 m/s. The evolution of the spatters showed that the more fully developed the state, the greater the number of spatters and the wider the contamination range. When the operation mode was moved from the central incisor to the first molar, the spatter direction became increasingly concentrated, and the velocities were enhanced. Larger droplets randomly moved along trajectories and rapidly settled. The aerosol cloud tended to float as a mass that interacted with the surrounding air. The high-volume evacuation could effectively clear away most of the dental spatters. The suction air purifier could change the diffusion direction of the spatters, compress the contamination range, and control aerosol escape into surrounding air. Conclusions: Our view is that we should combine the ‘point’ control measure (high-volume evacuation) and ‘area’ control measure (suction air purifier) to reduce the scope of pollution and prevent the aerosol escape into the surroundings. The study contributes to devising more accurate infection control guidelines, establishing appropriate interventions for different oral treatments, and minimizing the spread of respiratory diseases so that we can reduce cost and achieve the best results when medical resources are limited.
Comparison of [18F] NaF PET/CT Analysis Methods and Derivation of a Semi-population Input Function for Site Specific Measurements of Bone Formation in a Population With Chronic Kidney Disease Mineral and Bone Disorder
Authors: Vrist Marie Houmaa , Bech Jesper Nørgaard , Lauridsen Thomas Guldager , Fynbo Claire Anne , Theil Jørn 
Published: July 2021

Abstract
PurposeImplementation and comparison of non-invasive dynamic and static whole-body (WB) [18F]NaF PET/CT scan methods to replace invasive bone biopsy, used for quantitative analysis of bone clearance in patients with chronic kidney disease - mineral and bone disorder (CKD-MBD).MethodsSeventeen patients with CKD-MBD underwent a 60-minute dynamic scan followed by a 30-minute static WB scan. Tracer kinetics in four thoracic vertebrae were analyzed using non-linear regression and Patlak analysis using image-derived arterial input functions. We validated the use of a semi-population input function in this population.ResultsSkeletal plasma clearance (Ki) from Patlak analyses correlated well with non-linear regression analysis, but Ki-results using Patlak analysis were lower compared to Ki-results using non-linear regression analysis. However, no significant difference was found between Ki obtained by static WB scans and Ki obtained by dynamic scans using non-linear regression analysis (p=0.29). ConclusionOur results show good correlation between dynamic and static analysis of skeletal plasma clearance with no significant difference between the Ki-results obtained by non-linear regression analysis and the more clinically suitable static scan analysis method. We found lower Ki-results when Patlak analysis was applied. Thus, WB [18F]NaF PET/CT scans can be applied in future studies to measure Ki in CKD-BMD patients, but the results should not be compared uncritically with results obtained by dynamic scans analysis.
Skp2 Stabilizes Mcl-1 and Confers Radioresistance in Colorectal Cancer
Authors: Yu Xinfang , Zhou Li , Liu Wenbin , Liu lijun , Gao Feng , Li Wei , Liu Haidan 
Published: July 2021

Abstract
Background
Overexpression of Skp2 plays a critical role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, Skp2 has been proposed as an attractive target for anti-tumor interventions.
Methods
The expression of Skp2 in human colorectal cancer (CRC) and the role of Skp2 in tumorigenic properties and irradiation sensitivities of CRC cells were examined by anchorage-dependent and -independent growth assays, immunoblot, flow cytometry, immunohistochemical staining, ubiquitination analysis, co-immunoprecipitation assay, CRISPR-Cas9-based gene knockout, and xenograft experiments.
Results
Skp2 is highly expressed in CRC patient tissues. Blocking Skp2 expression reduces the tumorigenic properties of CRC cells in vitro and in vivo. Depletion of Skp2 confers sensitivity to irradiation of CRC cells. Skp2 deficiency enhances irradiation-induced intrinsic apoptosis by facilitating E3 ligase FBW7-mediated Mcl-1 ubiquitination and degradation. Knockout of Skp2 sensitizes CRC cells to irradiation treatments in vivo.
Conclusion
Our findings indicate that Skp2 stabilizes Mcl-1, and targeting Skp2 in combination with traditional radiotherapy might be efficacious in treating CRC.
TCF4 and HuR Mediated-METTL14 Suppresses Dissemination of Colorectal Cancer via N6-Methyladenosine-Dependent Silencing of ARRDC4
Authors: Wang Hao , Wei Wei , Zhang Zhong-Yuan , Liu Yao , Shi Bin , Zhong Wen , Zhang Hou-Shun , Fang Xin , Sun Chun-Lei , Wang Jia-Bei , Liu Lian-Xin 
Published: July 2021

Abstract
Background: Metastasis remains the major obstacle to improved survival for colorectal cancer (CRC) patients. Dysregulation of N6-methyladenosine (m6A) is causally associated with the development of metastasis through poorly understood mechanisms. Methods: The expression of METTL14 and its correlation with clinicopathological features were evaluated by western blot and immunohistochemistry. The roles of METTL14 in CRC metastasis were determined through in vitro and in vivo assays. The underlying mechanisms of METTL14 regulation were explored using transcriptome-sequencing, m6A-seguencing, methylated RNA immunoprecipitation (MeRIP), m6A dot blot, RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assay.Results: METTL14 is functionally related to the inhibition of ARRDC4/ZEB1 signaling and to the consequent suppression of CRC metastasis. We unveil METTL14-mediated m6A modification profile and identify ARRDC4 as a direct downstream target of METTL14. Knockdown of METTL14 significantly enhances ARRDC4 mRNA stability relying on the “reader” protein YHTDF2 dependent manner. Moreover, TCF4 can induce METTL14 protein expression, and HuR suppresses METTL14 expression by directly binding to its promoter. Clinically, decreased METTL14 is correlated with poor prognosis and acts as an independent predictor of CRC survival. Conclusion: Our data suggest that TCF4 and HuR mediated-METTL14 can trigger the metastasis of CRC during cancer development via YHTDF2/ARRDC4/ZEB1 axis, which imposes great challenge that inhibition of METTL14 is a potential approach for cancer treatment.
Identifying Functional Brain Abnormalities in Migraine and Depression Comorbidity
Authors: Yang Ying , Wei Kai , Zhang Hongchun , Hu Hongyun , Yan Li , Gui Wei , Liu Ying , Chen Xin 
Published: July 2021

Abstract
Background: Migraine and major depressive disorder (MDD) are both high prevalence brain disorders and often comorbidity. However, the neural mechanisms underlying the migraine and depression comorbidity are largely unknown. We aimed to explore the brain functional abnormalities associated with the co-occurrence of migraine and depression. Methods: High-resolution T1-weighted and resting-state functional magnetic resonance imaging were required from ninety-three well-matched subjects with migraineurs with depression, migraineurs without depression, patients with MDD and healthy controls (HC). Voxel-wise one-way and two-way analyses of variance in multiple functional variables were performed among the four groups. Furthermore, correlation analysis was conducted to detect the clinical significance of the altered brain functional regions.Results: Migraineurs with depression showed functional alterations in the default mode network (DMN), pain processing network (PPN), and visual network (VN) compared with HC. Migraineurs without depression exhibited abnormalities in the DMN, PPN, VN, and ventral attention network compared with HC. Furthermore, the abnormalities in the right paracentral lobule and left calcarine were significantly correlated with emotional scales in the pooled migraine patients. Conclusions: Migraineurs with and without depression revealed widely shared regional networks of function changes related to the DMN, PPN, and VN. Importantly, the right paracentral lobule and left calcarine may be the core regions for the neuropathological mechanism in migraine and depression comorbidity, and may contribute to the development of depression in migraineurs.
Structural and Vibrational Study of Molecular Interaction in a Ternary Liquid Mixture of Benzylamine, Ethanol and Benzene
Authors: . Hema , Bhatt Tara , Arya Pratibha , Dhondiyal Charu Ch. , Tiwari Himani , Devlal Kamal 
Published: July 2021

Abstract
The structural study of the non-covalent interactions in the ternary mixture of benzylamine (BA), ethanol and benzene have been attempted through Density Functional Theory (DFT) calculation. The optimized structure of monomers (BA, ethanol and benzene), BA dimer and their complexes (BA-benzene, BA-ethanol, BA-ethanol-benzene) and their interaction energy is used to describe the intermolecular interaction between the molecules. In addition to conventional H-bonding, the stability of the system is found to depend on several other interactions such as CH/π, NH/π, OH/π interaction. The Fourier Transform InfraRed (FTIR) spectroscopy technique is also used to study molecular interaction. An interpretation of the IR stretching bands based on the interactions is also provided. The variation in IR band position and intensity of spectra with change in concentration of the mixture shows that different kinds of interactions are presented in the mixture. The strength of these interactions varies with concentration. At lower concentration (x1=0.0), weak OH/π interaction between benzene and ethanol takes place while at other mole fraction N-H-----O, O-H------N, NH/π interaction is present between molecules.
The Angular Speed Distribution of Randomly Moving Particles
Authors: Guo Tao 
Published: July 2021

Abstract
Spin is a common phenomenon in nature, but the detailed statistical principle behind it is seldom discussed. This article aims to inspire people to think about such problems. In this article, probability theory and the corresponding modules of Mathematica software are used to study the distribution of angular speed generated by a population of equal speed particles moving randomly in space. The probability density expression of this distribution is derived successfully, and then its accuracy is verified by simulation data. Finally, it is confirmed that the angular speed follows the Maxwell distribution with a specified scale parameter. This research may be helpful for understanding why most celestial bodies or micro particles in the universe spin.