bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of graded alumina by spark plasma sintering
Authors: Bódis Eszter , Károly Zoltán 
Published: August 2021

AbstractFunctionally graded materials (FGMs) attract considerable interest in materials science and industry, since their composition or morphology gradually changes along their length, width, or height, which provides new approach for the development of multifunctional materials. In this paper, we studied the fabrication of a gradient microstructure in alumina (Al2O3) by spark plasma sintering (SPS). During the SPS process, the applied asymmetric graphite tool configuration causes a large temperature gradient, which results in a gradually changing morphology in Al2O3 ceramics. The local temperatures were quantitatively measured through extra thermocouples during SPS processes with various asymmetric configurations. In the most asymmetric configuration, a maximum vertical temperature difference of 225 °C was detected within the sample treated at a sintering temperature of 1300 °C and a pressure of 25 MPa applied 200 °C·min−1 heating rate. The microstructure investigations demonstrated the morphology gradient in the ceramic: one part of the Al2O3 exhibited fine, nanostructured morphology with large open and permeable pores, whereas the other part was solid without pores. Our investigations show that a gradient Al2O3 ceramic can be produced with a single-step SPS process, which offers new directions in FGMs research. With an asymmetric sintering configuration and the sintering conditions, the structure of the ceramic, such as porosity, can be designed according to the requirements of the application area.
Fano schemes of complete intersections in toric varieties
Authors: Ilten Nathan , Kelly Tyler L. 
Published: August 2021

AbstractWe study Fano schemes $$\mathrm{F}_k(X)$$

F
k

(
X
)

for complete intersections X in a projective toric variety $$Y\subset \mathbb {P}^n$$

Y
⊂

P

n

. Our strategy is to decompose $$\mathrm{F}_k(X)$$

F
k

(
X
)

into closed subschemes based on the irreducible decomposition of $$\mathrm{F}_k(Y)$$

F
k

(
Y
)

as studied by Ilten and Zotine. We define the “expected dimension” for these subschemes, which always gives a lower bound on the actual dimension. Under additional assumptions, we show that these subschemes are non-empty and smooth of the expected dimension. Using tools from intersection theory, we can apply these results to count the number of linear subspaces in X when the expected dimension of $$\mathrm{F}_k(X)$$

F
k

(
X
)

is zero.
The diet of greater crested terns off southeast Australia varies with breeding stage and sea surface temperature
Authors: Quiring Katrin , Carroll G. , Champion C. , Heymann E. W. , Harcourt R. 
Published: August 2021

AbstractMonitoring seabird diet can provide insights into marine ecosystems that are logistically difficult or costly to observe with traditional fisheries survey methods. Using digital photography, we described the diet of greater crested terns (Thalasseus bergii) breeding on Montague Island (36°15′ S, 150°13′ E), a colony located in an oceanographically dynamic region of southeast Australia. We investigated how the type and size of prey brought back to the colony changed in relation to both breeding stage and variation in local environmental conditions. 2469 prey items were identified to species or family level over 35 consecutive days of photo-sampling in 2018. Australian anchovy (Engraulis australis), a surface-schooling clupeid fish, was the most abundant prey returned to the colony during all breeding stages (84.5%). The proportion of anchovy increased from 77.0% when birds were provisioning their adult partners during incubation, to 92.4% when they were provisioning chicks, suggesting selective foraging behaviour on this energy-rich species to facilitate rapid chick growth. Anchovy size was significantly larger during incubation (91.1 ± 14.9 mm), smaller during early chick provisioning (71.8 ± 11.0 mm), and increased slightly during mid provisioning (79.6 ± 11.9 mm), indicating adaptive prey selection that is matched to the physical requirements of different breeding stages. The proportion of anchovy prey was also influenced by sea surface temperature (SST), with anchovy becoming more dominant with increasing local SSTs, up to ~ 17.5 °C. This study gives new insight into the types of prey that are seasonally available to predators in this region. The strong specialisation by greater crested terns for one energy-rich species of schooling fish (anchovy) suggests that variation in the size and composition of their prey may serve as an indicator of change in the pelagic ecosystem off southeast Australia.
Amniotic band syndrome associated with extremely severe atypical clefts of the orofacial region
Authors: Eshete Mekonen , Banko Muhidin Abdo , Hailu Abiye , Brhanu Abeje , Mossey Peter , Butali Azeez 
Published: August 2021

AbstractAmniotic band syndrome (ABS) is not a commonly seen birth defect; however, it may have the potential to be severe and life-threatening requiring adequate attention. We present a severe case of amniotic band syndrome which encircled the head of the neonate tightly causing severe deformity. In this case report, the amniotic band encircled the head causing a severe bilateral Tessier 7 cleft. To our knowledge, this is the most severe type of ABS reported in the literature thus far.Level of evidence: Level V, risk / therapeutic study.
FISH-TAMB, a Fixation-Free mRNA Fluorescent Labeling Technique to Target Transcriptionally Active Members in Microbial Communities
Authors: Harris Rachel L. , Vetter Maggie C. Y. Lau , van Heerden Esta , Cason Errol , Vermeulen Jan-G , Taneja Anjali , Kieft Thomas L. , DeCoste Christina J. , Laevsky Gary S. , Onstott Tullis C. 
Published: August 2021

AbstractKeystone species or ecological engineers are vital to the health of an ecosystem; however, often, their low abundance or biomass present challenges for their discovery, identification, visualization and selection. We report the development of fluorescent in situ hybridization of transcript-annealing molecular beacons (FISH-TAMB), a fixation-free protocol that is applicable to archaea and bacteria. The FISH-TAMB method differs from existing FISH methods by the absence of fixatives or surfactants in buffers, the fast hybridization time of as short as 15 min at target cells’ growth temperature, and the omission of washing steps. Polyarginine cell-penetrating peptides are employed to deliver molecular beacons (MBs) across prokaryotic cell walls and membranes, fluorescently labeling cells when MBs hybridize to target mRNA sequences. Here, the detailed protocol of the preparation and application of FISH-TAMB is presented. To demonstrate FISH-TAMB’s ability to label intracellular mRNA targets, differentiate transcriptional states, detect active and rare taxa, and keep cell viability, labeling experiments were performed that targeted the messenger RNA (mRNA) of methyl-coenzyme M reductase A (mcrA) expressed in (1) Escherichia coli containing a plasmid with a partial mcrA gene of the methanogen Methanosarcina barkeri (E. coli mcrA+); (2) M. barkeri; and (3) an anaerobic methanotrophic (ANME) enrichment from a deep continental borehole. Although FISH-TAMB was initially envisioned for mRNA of any functional gene of interest without a requirement of prior knowledge of 16S ribosomal RNA (rRNA)-based taxonomy, FISH-TAMB has the potential for multiplexing and going beyond mRNA and thus is a versatile addition to the molecular ecologist’s toolkit, with potentially widespread application in the field of environmental microbiology.
18F-FDG PET baseline radiomics features improve the prediction of treatment outcome in diffuse large B-cell lymphoma
Authors: Eertink Jakoba J. , van de Brug Tim , Wiegers Sanne E. , Zwezerijnen Gerben J. C. , Pfaehler Elisabeth A. G. , Lugtenburg Pieternella J. , van der Holt Bronno , de Vet Henrica C. W. , Hoekstra Otto S. , Boellaard Ronald , Zijlstra Josée M. 
Published: August 2021

Abstract
Purpose
Accurate prognostic markers are urgently needed to identify diffuse large B-Cell lymphoma (DLBCL) patients at high risk of progression or relapse. Our purpose was to investigate the potential added value of baseline radiomics features to the international prognostic index (IPI) in predicting outcome after first-line treatment.

Methods
Three hundred seventeen newly diagnosed DLBCL patients were included. Lesions were delineated using a semi-automated segmentation method (standardized uptake value ≥ 4.0), and 490 radiomics features were extracted. We used logistic regression with backward feature selection to predict 2-year time to progression (TTP). The area under the curve (AUC) of the receiver operator characteristic curve was calculated to assess model performance. High-risk groups were defined based on prevalence of events; diagnostic performance was assessed using positive and negative predictive values.

Results
The IPI model yielded an AUC of 0.68. The optimal radiomics model comprised the natural logarithms of metabolic tumor volume (MTV) and of SUVpeak and the maximal distance between the largest lesion and any other lesion (Dmaxbulk, AUC 0.76). Combining radiomics and clinical features showed that a combination of tumor- (MTV, SUVpeak and Dmaxbulk) and patient-related parameters (WHO performance status and age > 60 years) performed best (AUC 0.79). Adding radiomics features to clinical predictors increased PPV with 15%, with more accurate selection of high-risk patients compared to the IPI model (progression at 2-year TTP, 44% vs 28%, respectively).

Conclusion
Prediction models using baseline radiomics combined with currently used clinical predictors identify patients at risk of relapse at baseline and significantly improved model performance.

Trial registration number and date
EudraCT: 2006–005,174-42, 01–08-2008.
Finite-size effects on the evolution of magnetic correlations and magnetocaloric properties of Pr0.4Bi0.2Sr0.4MnO3
Authors: Souza Anita D. , Vagadia Megha , Daivajna Mamatha D. 
Published: August 2021

AbstractThe effect of particle size reduction on the magnetic correlations of Pr0.4Bi0.2Sr0.4MnO3 nanoparticles prepared by top-down approach has been studied in detail. It was observed that as the milling time increases from 0 to 240 min, particle size decreases from 160 to 12 nm. Correspondingly it was observed that the ferromagnetic transition temperature (TC) drops (264 to 213 K) and saturation magnetization (MS) decreases (2.12–0.41 $${\upmu }_{\mathrm{B}}/\mathrm{f}.\mathrm{u}.$$

μ
B

/
f
.
u
.

) while coercivity (HC) shows a monotonous increase (0.18–1.5 kOe) as the particle size decreases due to increase in milling. The magnetic entropy change (ΔS) also decreases (2.41–0.24 J/kg-K) as particle size decreases indicating a strong correlation between magnetism and particle size. The metamagnetic M–H response of the bulk sample, which signifies the magnetic phase coexistence, is suppressed, and the nature of magnetic interactions demonstrates a transition from long range to short range. The observed characteristics emphasizes that with particle size reduction there is an increase in the surface disorder which can be explained by considering the core–shell model for the nanoparticles.
Graphic abstract
An empirical study on hospital-based prevention of recurrent urinary stone disease in Germany
Authors: Reicherz Alina , Rausch Patricia , Herout Roman , Noldus Joachim , Bach Peter 
Published: August 2021

Abstract
Purpose
Urinary stone disease is a common disease with a prevalence of 4.7% in Germany. The incidence increased over the last decades, and recurrence rates are up to 50% in the first 5 years after diagnosis. Adequate preventive measures can avoid up to 46% of stone recurrences. These numbers outline the importance of prevention. Especially among high-risk stone formers, specific diagnostics and measures are required. Published data indicate the divergence between the importance of prevention and its implementation in everyday clinical practice. This is the first survey among German urological departments highlighting medical care concerning the prevention of recurrent urinary stone disease, identifying challenges and providing recommendations for improvements.

Methods
Two hundred and seventy urological hospital departments in Germany were anonymously surveyed about measurements to prevent recurrent stone disease. The questionnaire comprised 23 items dealing with diagnostics, counselling, knowledge among doctors concerning preventive measures and difficulties in preventing recurrent urinary stone disease.

Results
Sixty-three urological departments (23.8%) answered the survey. The majority perform stone analysis at first and repeat events. Most patients with urinary stone disease receive general advice on preventive measures during their hospitalization. General recommendations focus on fluid intake and lifestyle changes. However, specific diets are infrequently recommended by inpatient urologists. Diagnostics to identify high-risk stone formers are mostly insufficient, and guideline-compliant urine tests are uncommon.

Conclusion
The quality of secondary prevention needs to improve considerably. The focus should be put on identifying high-risk stone formers and offering those patients specific counselling. Furthermore, general advice on dietary recommendations should be extended.
Robotics improves alignment accuracy and reduces early revision rates for UKA in the hands of low-volume UKA surgeons
Authors: Savov Peter , Tuecking Lars-Rene , Windhagen Henning , Calliess Tilman , Ettinger Max 
Published: August 2021

Abstract
Purpose
It is known that in uni-compartmental knee arthroplasty (UKA) low-volume surgeons have a higher complication and revision rate than high-volume surgeons. Further, robotic-assisted UKA leads to lower early revision rate as well as fewer limb and joint line outliers compared to conventional UKA. The purpose of this study was to retrospectively analyze the outliers’ and revision rate of low-volume UKA surgeons with different robotic systems at short-term follow-up.

Methods
In this case–control study, 103 robotic-assisted UKAs were included. The procedures were performed between 2016 and 2019 from two low-volume UKA surgeons with an imageless (IL) (63 patients) and image-based (IB) (40 patients) robotic system. Alignment outliers, joint line (JL) reconstruction, complication and revision rates of the two different robotic systems were analyzed. The minimum follow-up was two years. Outliers were defined as a postoperative valgus malalignment greater than 182°. The surgery time for all procedures was evaluated.

Results
The overall revision rate was 3.9% (4 of 103). Two occurred in the IB group (5.0%) and two in the IL group (3.2%). No valgus malalignment outliers were observed in both groups. The mean JL was not distalized by more than 2 mm in both groups (IL: 1.3 ± 1.6 mm vs. IB: 1.8 ± 0.9 mm, p value 0.08). The IL procedures had a significant lower mean surgery time (55 ± 13 min vs. 68 ± 14, p value 0.001).

Conclusion
Robotic-assisted UKA is a safe procedure in the hand of low-volume UKA surgeons. Robotic-assisted UKA minimizes overcorrection into valgus mal-alignment. Low revision rates are observed at short-term follow-up for robotic-assisted UKA. The choice of the different robotic systems has no impact on the outcome.
Pathologic myopia and severe pathologic myopia: correlation with axial length
Authors: Flores-Moreno Ignacio , Puertas Mariluz , Almazán-Alonso Elena , Ruiz-Medrano Jorge , García-Zamora María , Vega-González Rocío , Ruiz-Moreno José M. 
Published: August 2021

Abstract
Purpose
This study had three aims: (1) correlate axial length (AL), age and best-corrected visual acuity in high myopic patients scored on the ATN grading system; (2) determine AL cut-off values to distinguish between pathologic myopia (PM) and severe PM; and (3) identify clinical differences between PM and severe PM.

Methods
This is a cross-sectional, non-interventional study. All patients underwent complete ophthalmologic examination, ATN grading and multimodal imaging (colour fundus photography, swept-source OCT, fundus autofluorescence, OCT angiography and fluorescein angiography).

Results
Six hundred forty-four eyes from 345 high myopic patients were included. The eyes were graded on the ATN system and classified as PM (≥ A2) or severe PM (≥ A3, ≥ T3 and/or N2). Significant between-group (PM vs. severe PM) differences (p < 0.05) were observed on the individual ATN components (atrophic [A], tractional [T] and neovascular [N]), age, BCVA and AL. AL was also linearly correlated with the A, T and N components (r = 0.53, p < 0.01; r = 0.24, p < 0.01; r = 0.20, p < 0.01; respectively). ROC curve analysis showed the optimal AL cut-off value to distinguish between PM at 28 mm (AUC ROC curve: 0.813, specificity: 75%, sensitivity: 75%) and severe PM at 29.50 mm (AUC ROC curve: 0.760, specificity: 75%, sensitivity: 70%).

Conclusion
AL is the main variable associated with myopic maculopathy. Due to the clinical differences found between PM and severe PM, there is need to create an objective cut-off point to distinguish these two different entities being the optimal cut-off points for AL 28 mm and 29.5 mm, respectively. These objective AL cut-off values should be taken into account for determining a correct follow-up, ophthalmic management and treatment.
Gastrodermis ultrastructure of the different life stages of the polyopisthocotylean monogenean gill parasite Discocotyle sagittata
Authors: Cable Joanne , El-Naggar Mohamed Mohamed 
Published: August 2021

AbstractThe polyopisthocotylean Discocotyle sagittata is a blood-feeding monogenean that infects the gill lamellae of rainbow trout, Oncorhynchus mykiss, and brown trout, Salmo trutta. The ultrastructure of their alimentary tract, at different stages of the life cycle, was previously unknown. Here, we show that the gastrodermis of the oncomiracidium, subadult, and adult D. sagittata follows the same structural organization as that of other blood-feeding polyopisthocotyleans, being composed of digestive cells alternating with a connecting syncytium. Digestive cells of the oncomiracidium are found in three developmental forms: undifferentiated, developing differentiated, and differentiated (presumably functioning) cells whereas those of adult and subadult are present in a single functioning state with variable size and content. The apical cytoplasm of adult digestive cells forms conical outgrowths, a feature which is absent in the oncomiracidium. The connecting syncytium of the oncomiracidium has no evidence of metabolic activity, while that of adult and subadult is metabolically active. The lamellae of the connecting syncytium of adults and subadults are more numerous and larger, and their terminal portions are expanded, compared with those of the oncomiracidium. Parallel, tubular, membranous structures are characteristic of the apical cytoplasm of the connecting syncytium of the oncomiracidium. Luminal lamella in the oncomiracidium, subadult, and adult form balloon-like structures enclosing some luminal contents, but those of the oncomiracidium are larger, bounded by nucleated cytoplasmic layer, and enclose more luminal contents. The possible functions of these structures and mechanism of digestion in both oncomiracidium and adult are discussed.
Elternzentrierte ethische Entscheidungsfindung für Frühgeborene im Grenzbereich der Lebensfähigkeit – Reflexion über die Bedeutung probabilistischer Prognosen als Entscheidungsgrundlage
Authors: Kidszun André 
Published: August 2021

ZusammenfassungFrühgeborene im Grenzbereich der Lebensfähigkeit befinden sich in einer prognostischen Grauzone. Das bedeutet, dass deren Prognose zwar schlecht, aber nicht hoffnungslos ist, woraus folgt, dass nach Geburt lebenserhaltende Behandlungen nicht obligatorisch sind. Die Entscheidung für oder gegen lebenserhaltende Maßnahmen ist wertbeladen und für alle Beteiligten enorm herausfordernd. Sie sollte eine zwischen Eltern und Ärzt*innen geteilte Entscheidung sein, wobei sie unbedingt mit den Präferenzen der Eltern abgestimmt sein sollte. Bei der pränatalen Beratung der Eltern legen die behandelnden Ärzt*innen üblicherweise numerische Schätzungen der Prognose vor und nehmen in der Regel an, dass die Eltern ihre Behandlungspräferenzen davon ableiten. Inwieweit probabilistische Daten die Entscheidungen der Eltern in prognostischen Grauzonen tatsächlich beeinflussen, ist noch unzureichend untersucht. In der hier vorliegenden Arbeit wird eine Studie reflektiert, in welcher die Hypothese geprüft wurde, dass numerisch bessere oder schlechtere kindliche Prognosen die Präferenzen werdender Mütter für lebenserhaltende Maßnahmen nicht beeinflussen. In dieser Studie zeigte sich, dass die elterlichen Behandlungspräferenzen eher von individuellen Einstellungen und Werten als von Überlegungen zu numerischen Ergebnisschätzungen herzurühren scheinen. Unser Verständnis, welche Informationen werdende Eltern, die mit einer extremen Frühgeburt konfrontiert sind, wünschen und brauchen, ist noch immer unvollständig. Bedeutende medizinische Entscheidungen werden keineswegs nur rational und prognoseorientiert gefällt. In der vorliegenden Arbeit wird diskutiert, welchen Einfluss der Prozess der Entscheidungsfindung auf das Beratungsergebnis haben kann und welche Implikationen sich aus den bisher vorliegenden Studienergebnissen ergeben – klinisch-praktisch, ethisch und wissenschaftlich.
The impact of COVID-19 lockdown on child and adolescent mental health: systematic review
Authors: Panchal Urvashi , Salazar de Pablo Gonzalo , Franco Macarena , Moreno Carmen , Parellada Mara , Arango Celso , Fusar-Poli Paolo 
Published: August 2021

AbstractCOVID-19 was declared a pandemic in March 2020, resulting in many countries worldwide calling for lockdowns. This study aimed to review the existing literature on the effects of the lockdown measures established as a response to the COVID-19 pandemic on the mental health of children and adolescents. Embase, Ovid, Global Health, PsycINFO, Web of Science, and pre-print databases were searched in this PRISMA-compliant systematic review (PROSPERO: CRD42021225604). We included individual studies reporting on a wide range of mental health outcomes, including risk and protective factors, conducted in children and adolescents (aged ≤ 19 years), exposed to COVID-19 lockdown. Data extraction and quality appraisal were conducted by independent researchers, and results were synthesised by core themes. 61 articles with 54,999 children and adolescents were included (mean age = 11.3 years, 49.7% female). Anxiety symptoms and depression symptoms were common in the included studies and ranged 1.8–49.5% and 2.2–63.8%, respectively. Irritability (range = 16.7–73.2%) and anger (range = 30.0–51.3%), were also frequently reported by children and adolescents. Special needs and the presence of mental disorders before the lockdown, alongside excessive media exposure, were significant risk factors for anxiety. Parent–child communication was protective for anxiety and depression. The COVID-19 lockdown has resulted in psychological distress and highlighted vulnerable groups such as those with previous or current mental health difficulties. Supporting the mental health needs of children and adolescents at risk is key. Clinical guidelines to alleviate the negative effects of COVID-19 lockdown and public health strategies to support this population need to be developed.