bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Coastal Sand Deposits From Tsunamis and Storm Waves Based on Numerical Computations
Authors: Watanabe Masashi , Goto Kazuhisa , Roeber Volker , Imamura Fumihiko 
Published: June 2021

AbstractTsunami and storm deposits can be utilized for estimating inundation zones and recurrence intervals of extreme waves in modern, historic, and prehistoric times. However, the distribution of these deposits is extremely complex and affected by various factors such as the size of the waves, topography, bathymetry, and the supply of sediment and its properties. Here, we use numerical computations to identify the key factors affecting the inundation extent of tsunamis and storm waves, and which subsequently govern the distribution of the corresponding coastal sand deposits. The results demonstrate that the overall topography slope has the most significant impact on the inundation extent of tsunamis and storm waves and subsequently the inland distribution distance of the transported deposits. The existence of onshore sediment sources is crucial for estimating the maximum extent of storm deposits because only a limited amount of sediment is carried inland by the storm waves. In contrast, the presence of onshore sediment sources is less critical for the delineation of the maximum distribution envelope of tsunami deposits compared to other parameters. The parameters that mainly control the sediment deposit volume over land under tsunami and storm wave conditions are the grain size and wave height, respectively. Our computed results are summarized using the Dean number, Shields number, and Iribarren number showing an inter‐connectivity between topography, input wave characteristic, and onshore distributions of both types of deposits. Despite some simplifications, this approach can efficiently lead to an identification and reconstruction of past catastrophic wave events.
Constraining Shallow Seawater Oxygenation for the Yangtze Platform During the Early Cambrian
Authors: Frank A. B. , Klaebe R. M. , Xu L. , Frei R. 
Published: June 2021

AbstractWhile atmospheric oxygenation occurred largely in two major steps, the oxygenation of Earth's oceans is assumed to be more complicated, shifting repeatedly between oxic and anoxic conditions. The exact timeline and causal drivers of these changes, which seemingly culminated in the well‐ventilated oceans we see today are not well understood. This study presents Cr isotope and rare earth element + yttrium (REE + Y) data combined with V/Cr ratios for the calcareous Yanjiahe and shaley Shuijingtuo Formations from the shelf of the Yangtze Block, South China, to improve our understanding of marine redox conditions during the early Cambrian. We measured authigenic δ53Cr values of up to 1.38‰ for the carbonates of the Yanjiahe Formation as well as Ce anomalies as low as 0.57 suggesting deposition under oxic conditions. The Shuijingtuo Formation is characterized by authigenic δ53Cr values as high as 1.27‰ at its base, but shows a strong increase in detrital content upwards, masking authigenic Cr isotope values and dissolved marine REE + Y profiles. The upper Shuijingtuo Formation is characterized by V/Cr ratios as high as 27, which indicate anoxic conditions. Hence, our data support a prevalence of oxic seawater conditions in the shallow seawater of the Yangtze Block during the Ediacaran‐Cambrian transition, which shifted repeatedly to anoxic during the early Cambrian likely as a result of sea level rise and a redox‐stratified ocean.
HNRNPH1-stabilized LINC00662 promotes ovarian cancer progression by activating the GRP78/p38 pathway
Authors: Wu Yong , Guo Qinhao , Ju Xingzhu , Hu Zhixiang , Xia Lingfang , Deng Yu , Zhao Ping , Zhang Meng , Shao Yang , Huang Shenglin , He Xianghuo , Wen Hao , Wu Xiaohua 
Published: June 2021

AbstractNumerous studies suggest an important role for copy number alterations (CNAs) in cancer progression. However, CNAs of long intergenic noncoding RNAs (lincRNAs) in ovarian cancer (OC) and their potential functions have not been fully investigated. Here, based on analysis of The Cancer Genome Atlas (TCGA) database, we identified in this study an oncogenic lincRNA termed LINC00662 that exhibited a significant correlation between its CNA and its increased expression. LINC00662 overexpression is highly associated with malignant features in OC patients and is a prognostic indicator. LINC00662 significantly promotes OC cell proliferation and metastasis in vitro and in vivo. Mechanistically, LINC00662 is stabilized by heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1). Moreover, LINC00662 exerts oncogenic effects by interacting with glucose-regulated protein 78 (GRP78) and preventing its ubiquitination in OC cells, leading to activation of the oncogenic p38 MAPK signaling pathway. Taken together, our results define an oncogenic role for LINC00662 in OC progression mediated via GRP78/p38 signaling, with potential implications regarding therapeutic targets for OC.
PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment
Authors: Ji Guangyu , Zhou Wenjuan , Du Jingyi , Zhou Juan , Wu Dong , Zhao Man , Yang Liping , Hao Aijun 
Published: June 2021

AbstractColorectal cancer (CRC) stem cells are resistant to cancer therapy and are therefore responsible for tumour progression after conventional therapy fails. However, the molecular mechanisms underlying the maintenance of stemness are poorly understood. In this study, we identified PCGF1 as a crucial epigenetic regulator that sustains the stem cell-like phenotype of CRC. PCGF1 expression was increased in CRC and was significantly correlated with cancer progression and poor prognosis in CRC patients. PCGF1 knockdown inhibited CRC stem cell proliferation and CRC stem cell enrichment. Importantly, PCGF1 silencing impaired tumour growth in vivo. Mechanistically, PCGF1 bound to the promoters of CRC stem cell markers and activated their transcription by increasing the H3K4 histone trimethylation (H3K4me3) marks and decreasing the H3K27 histone trimethylation (H3K27me3) marks on their promoters by increasing expression of the H3K4me3 methyltransferase KMT2A and the H3K27me3 demethylase KDM6A. Our findings suggest that PCGF1 is a potential therapeutic target for CRC treatment.
Graph‐colouring based pilot assignment to mitigate downlink pilot contamination for cell‐free massive MIMO systems
Authors: Haj Hmida Wafa , Meghdadi Vahid , Bouallegue Ammar , Cances Jean Pierre 
Published: June 2021

AbstractIn cell‐free massive multiple‐input‐multiple‐output (CF‐MMIMO) systems, a massive number of access points, mastered by central processing units are distributed in a coverage area to serve much smaller number of user equipments (UEs) simultaneously over the same time/frequency resources. In opposition to the centralized MMIMO, CF‐MMIMO particularity is that its channel hardening degree is not sufficiently accentuated, thus, it will be judicious to include downlink (DL) pilots in order for the DL channel to be estimated. This paper considers the DL pilot assignment for the CF‐MMIMO systems by defining a metric, involving the inter‐user interference. This metric gives insights into DL pilot contamination. A threshold is then defined to optimize the number of DL pilots, which maximizes the minimum per‐user DL throughput. This approach gives a conflict graph, where each UE is regarded as a vertex of the graph. This is a combinatorial optimization problem that can be approximated using graph‐colouring algorithms. The simulation results reveal that the proposed method outperforms interestingly, in terms of per‐user DL throughput, the existing methods such as statistical channel state information, the orthogonal, and the random pilot assignment in the DL training.
New relaxed stability and stabilization conditions for T‐S fuzzy systems with time‐varying delays
Authors: Zhou Kun , Wang Binrui , Qi Shunan 
Published: June 2021

AbstractThis paper investigates the stability analysis and stabilization of T‐S fuzzy systems with time‐varying delays. First, a new augmented Lyapunov–Krasovskii functional is constructed, delay‐dependent stability criteria in terms of linear matrix inequalities (LMIs) are obtained by combining them with the integral inequality technique and the reciprocally convex combination inequality. Based on the state space decomposition method, some piecewise membership functions are employed to approximate the membership functions. The piecewise membership functions can be locally represented in terms of the convex combinations of the supremum and infimum of some local basis functions. The boundary information of the membership functions is adequately taken into consideration in stability analysis, and then some relaxed membership‐function‐dependent stability results are obtained. Second, state feedback controllers for fuzzy systems with time‐varying delays are presented under the imperfect premise‐matching technique, whose membership functions and the number of fuzzy rules are allowed to be designed freely, consequently, the flexibility of controller design is improved. Finally, four numerical examples are given to demonstrate the effectiveness of the presented approaches.
Generalised dual‐filter disturbance observer for nonminimum‐phase systems
Authors: Deng Jiuqiang , Zhou Xi , Mao Yao 
Published: June 2021

AbstractTo reject the disturbances of the nonminimum‐phase systems, the generalised dual‐filter disturbance observer is proposed. The conventional disturbance observer methods inevitably lead to nonminimum‐phase systems' instability. To stabilise the system, the forward plant and dual filters are introduced. The stability constraints are transferred to the dual filters. Based on any stable designs of the close‐loop controller, the dual filters can be easily designed. The simulations effectively verify that the disturbance rejection performances of the proposed method are triple those of the closed‐loop nonminimum‐phase system, and the original system's tracking capabilities and stability margins are few affected.
Bidirectional speed range extension of DFIG‐based WECS with dynamic minimum dc‐bus voltage
Authors: Jia Feng , Zi Erming , Fu Yang , Cai Xu 
Published: June 2021

AbstractEnlarging the speed range of wind turbines is an effective way to increase power production in low‐frequency band wind which contains more energy and is very challenging for DFIG‐based wind energy conversion system (WECS). The analysis shows that current controllability of the converter is the main factor limiting bidirectional speed range extension (BSRE). This problem can be solved by increasing dc‐bus voltage, but a constant and high dc‐bus voltage will increase the electrical stress and switching losses of the converter. This paper proposed a dynamic minimum dc‐bus voltage (DMDCV) technique in which the dc‐bus voltage can automatically adjust to enable the back‐to‐back voltage source converter to work in linear modulation mode at its minimum value, thus supporting BSRE while also achieving multiple goals including low electrical stress and low switching losses. Two implementation methods of DMDCV with and without modulation depth loop are proposed and discussed. The co‐simulation results verified the feasibility of DMDCV and the advantages of BSRE in improving power generation.
Influence of a target’s inclination on LiDAR waveform and its application
Authors: Yang Tao , Lai Jiancheng , Wang Chunyong , Yan Wei , Ji Yunjing , Zhao Yan , Wu Zhixiang , Li Zhenhua 
Published: June 2021

AbstractInclination is one of the important parameters of a target’s surface, which is closely related to the waveform of light detection and ranging. When the target is tilted, the laser spot on the target’s surface changes greatly, and the influence of the target on the echo signal is more complex. Here, the formation process of a laser’s echo signal is explored. On that basis, the spot distribution model in the case of a large incident angle is optimised, and a comparison is made with the conventional method. A simulation system which can produce and display the signal affected by the inclined target is designed. In view of the difficulty in extracting the target's inclination from the echo signal, a method based on waveform analysis is proposed in this article. Then a calculation model is built to retrieve the inclination of the target from the echo signal by data fitting. The maximum measured error is only 0.948°, and the maximum root‐mean‐squared‐error is only 0.45°.
Effects of Mediterranean Diet in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Randomized Controlled Trials
Authors: Kawaguchi Takumi , Charlton Michael , Kawaguchi Atsushi , Yamamura Sakura , Nakano Dan , Tsutsumi Tsubasa , Zafer Maryam , Torimura Takuji 
Published: June 2021

AbstractWe conducted a meta-analysis to investigate the effects of the Mediterranean Diet (Med-Diet) on hepatic steatosis and insulin resistance in patients with nonalcoholic fatty liver disease (NAFLD). Six randomized controlled trials were selected for the meta-analysis (sample size: 250 participants). In the meta-analysis, there was no significant difference in body mass index and waist circumference between the Med-Diet and control groups. Med-Diet significantly reduced fatty liver index (FLI) compared with the control diet (standard mean difference [SMD]: –1.06; 95% CI: –1.95 to –0.17; p = 0.02). Med-Diet significantly reduced homeostasis model assessment of insulin resistance (HOMA-IR) compared with the control diet (SMD: –0.34; 95% CI: –0.65 to –0.03; p = 0.03). Similarly, a meta-regression analysis using age showed that Med-Diet significantly reduced FLI and HOMA-IR (95% CI: –0.956 to –0.237, p = 0.001 and 95% CI: –0.713 to –0.003, p = 0.048, respectively). This meta-analysis demonstrated that Med-Diet improved hepatic steatosis and insulin resistance in patients with NAFLD. Thus, Med-Diet is a beneficial pharmaconutritional therapy in patients with NAFLD.
Pseudobasophilia as a Screening Tool in Dengue: A Single Center Study
Authors: Manuel Kevin , Ambroise Marie Moses , Ramdas Anita , Varghese Renu G'Boy 
Published: June 2021

AbstractObjectives Proper serological testing for the definite diagnosis of dengue is costly and may not be easily available in a resource-limited setting. Hematological parameters can help in the early identification of dengue cases. This study aims to evaluate the occurrence and utility of pseudobasophilia in identifying dengue-affected patients.Materials and Methods This retrospective cross-sectional study included 1,304 dengue cases confirmed by serology and 1,044 dengue serology negative acute febrile illness cases as controls. Complete blood count (CBC) values of the first EDTA (ethylenediamine tetraacetic acid) blood sample from automated hematology analyzers were reviewed. The hematological parameters in the dengue and control groups were compared and the variation of these parameters with the day of fever was also analyzed.Statistical Analysis Mann-Whitney’s test, Kruskal-Wallis test, and Fisher’s exact test were used for statistical analysis. A p-value < 0.05 was considered statistically significant for all tests.Results There was a statistically significant variation between dengue cases and controls for hematocrit, platelet count, mean platelet volume, total white blood cell count, and absolute basophil count. The dengue group had a higher hematocrit from day 2 to day 10, platelet count ≤ 100,000/µL from day 4 to day 9, higher mean platelet volume from day 2 to day 7, leucopenia from day 3 to day 5, and higher absolute basophil count from day 2 to day 10. Interestingly, pseudobasophilia was seen in 533 (40.87%) of dengue cases and only 3 (0.28%) of the controls. Pseudobasophilia was also observed to have an increasing trend to the day of fever.Conclusion Pseudobasophilia along with other CBC parameters is useful and cost effective for the early identification of dengue. This can prompt early investigations and supportive treatment leading to improved clinical outcomes.
Facial Neuritis as a Manifestation of Gradenigo's Syndrome
Authors: Kentab Amal Y. , Kentab Osama Y. 
Published: June 2021

AbstractGradenigo's syndrome (GS) is a rare, acquired syndrome caused by middle ear infections or mastoiditis. It is identified by the triad of otorrhea due to otitis media (OM), retro-orbital pain in the region innervated by the first and second divisions of the trigeminal nerve, and diplopia as a result of cranial nerve (CN) VI palsy. As a result of extension of the inflammation, the facial nerve (VII) may also be affected. GS has a poor prognosis unless promptly diagnosed and treated. Herein, we report the clinical and radiological findings observed in two children diagnosed with chronic suppurative OM, mastoiditis, and facial neuritis. Both were medically managed as cases of GS with high-dose intravenous antibiotic and full recovery was achieved a few weeks after discharge. There was no need for any surgical intervention. This case report illustrates the importance of early recognition, diagnosis, and treatment of this treatable syndrome using antibiotics to prevent subsequent fatal complications and further need for surgical intervention.
Back Transfer of Infants with Tracheostomies: A Regional Center Experience
Authors: Attar Mohammad A. , Pace Rachael A. , Schumacher Robert E. 
Published: June 2021

AbstractWe describe our center's experience with the back transfer of infants following tracheostomies. We conducted a retrospective cohort study of infants transferred to pediatric critical care units of our regional center with conditions originating in the neonatal period who underwent tracheostomy during the hospitalization within their first year of life between 2006 and 2017. Recovering patients are discharged home or transferred back to the referring hospitals. We evaluated patient characteristics, destination of discharge and type of pulmonary support at discharge, and mechanical ventilation (MV) or tracheotomy masks (TM). Of the 139 included patients, 72% were transferred to the neonatal intensive care unit, 21% to the pediatric cardiothoracic unit, and 7% to the pediatric intensive care unit. Their median gestational age was 35 weeks. They were admitted at a median 22 days of life and lived at a median distance of 56 miles from our center. Furthermore, 34 infants (24%) were back transferred closer to their homes (23 with MV and 11 with TM), and 84 (60%) were discharged home (53 on MV and 31 on TM). Twenty-one patients (15%) died in the hospital (before discharge or transfer). Back transferred patients on MV had a significantly shorter duration between tracheostomy and transfer compared with those discharged home from our center: MV (median = 22 vs. 103 days, p < 0.0001) and TM (median = 13 vs. 35 days, p < 0.0001). Back transfer of infants with tracheostomies closer to their homes was associated with a significantly shorter hospitalization and more efficient use of the subspecialized resources at the RC.
Identification of Multisystem Inflammatory Syndrome in Children Classes and Development of Hyperinflammation Score in Pediatric COVID-19
Authors: Totapally Balagangadhar R. , Nadiger Meghana , Hassor Sophia , Laufer Marcelo , Etinger Veronica , Ramos Otto , Biehler Jefry , Meyer Keith , Melnick Steven 
Published: June 2021

AbstractThe aim of this study is to describe characteristics and hospital course of children admitted with COVID-19 to a tertiary care pediatric center in Southeastern United States, and to present the frequency of three classes of multisystem inflammatory syndrome in children (MIS-C) and develop pediatric COVID-19 associated hyperinflammation score (PcHIS). A retrospective cohort study of 68 children was performed. Critical illness was defined as any child requiring respiratory or cardiovascular support or renal replacement therapy. PcHIS was developed by using six variables: fever, hematological dysfunction, coagulopathy, hepatic injury, macrophage activation, and cytokinemia. Centers for Disease Control and Prevention criteria were used to identify MIS-C, and three classes of MIS-C were identified based on the findings of recently published latent class analysis (Class 1: MIS-C without Kawasaki like disease, Class 2: MIS-C with respiratory disease, and Class 3: MIS-C with Kawasaki like disease). The median age was 6.4 years. Fever, respiratory, and gastrointestinal were common presenting symptoms. MIS-C was present in 32 (47%), critical COVID-19 illness in 11 (16%), and 17 (25%) were admitted to the PICU. Children with critical illness were adolescents with elevated body mass index and premorbid conditions. PcHIS score of 3 had a sensitivity of 100% and a specificity of 77% for predicting critical COVID-19 illness. Among MIS-C patients, 15 (47%) were in Class 1, 8 (25%) were in Class 2, and 9 (28%) were in Class 3. We conclude that most children with COVID-19 have mild-to-moderate illness. Critical COVID-19 is mainly seen in obese adolescents with premorbid conditions. Three Classes of MIS-C are identifiable based on clinical features. Validation and clinical implication of inflammation score in pediatric COVID-19 need further investigation.
Cognitive and Behavioral Profiles of Children with Aspartylglucosaminuria: A Case Series
Authors: Crowe Louise M. , Brown Amy , Peters Heidi 
Published: June 2021

AbstractAspartylglucosaminuria (AGU) is a rare lysosomal storage disorder with an autosomal recessive inheritance. It affects the aspartylglucosaminidase (AGA) gene and causes a deficiency in activity of the enzyme N-aspartyl-β-glucosaminidase with resultant accumulation of glycoasparagines in body tissues. Children with AGU present with developmental delays in cognitive and language skills. Currently, information on cognition and behavior of children with AGU is limited. This case series presents the neuropsychological and behavioral profiles of three children with AGU assessed at two time points. All the three children had full-scale intelligence quotient (IQ) scores in the intellectual disabled range (<70). IQ had declined since their previous cognitive assessment 1 to 2 years prior. Other cognitive skills were significantly below expected levels. Parents reported several behavioral problems and adaptive difficulties. The findings challenge current beliefs that cognition is impaired but stable in children with declines seen in a short time.