bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors
Authors: Beyranvand Nejad Elham , Labrie Camilla , van Elsas Marit J , Kleinovink Jan Willem , Mittrücker Hans-Willi , Franken Kees L M C , Heink Sylvia , Korn Thomas , Arens Ramon , van Hall Thorbald , van der Burg Sjoerd H 
Published: April 2021

BackgroundHigh serum interleukin (IL-6) levels may cause resistance to immunotherapy by modulation of myeloid cells in the tumor microenvironment. IL-6 signaling blockade is tested in cancer, but as this inflammatory cytokine has pleiotropic effects, this treatment is not always effective.MethodsIL-6 and IL-6R blockade was applied in an IL-6-mediated immunotherapy-resistant TC-1 tumor model (TC-1.IL-6) and immunotherapy-sensitive TC-1.control. Effects on therapeutic vaccination-induced tumor regression, recurrence and survival as well on T cells and myeloid cells in the tumor microenvironment were studied. The effects of IL-6 signaling in macrophages under therapy conditions were studied in Il6rafl/fl×LysMcre+ mice.ResultsOur therapeutic vaccination protocol elicits a strong tumor-specific CD8+ T-cell response, leading to enhanced intratumoral T-cell infiltration and recruitment of tumoricidal macrophages. Blockade of IL-6 signaling exacerbated tumor outgrowth, reflected by fewer complete regressions and more recurrences after therapeutic vaccination, especially in TC-1.IL-6 tumor-bearing mice. Early IL-6 signaling blockade partly inhibited the development of the vaccine-induced CD8+ T-cell response. However, the main mechanism was the malfunction of macrophages during therapy-induced tumor regression. Therapy efficacy was impaired in Il6rafl/fl×LysMcre+ but not cre-negative control mice, while no differences in the vaccine-induced CD8+ T-cell response were found between these mice. IL-6 signaling blockade resulted in decreased expression of suppressor of cytokine signaling 3, essential for effective M1-type function in macrophages, and increased expression of the phagocytic checkpoint molecule signal-regulatory protein alpha by macrophages.ConclusionIL-6 signaling is critical for macrophage function under circumstances of immunotherapy-induced tumor tissue destruction, in line with the acute inflammatory functions of IL-6 signaling described in infections.
Averages of b-hadron, c-hadron, and $$\tau $$-lepton properties as of 2018
Authors: Amhis Y. , Banerjee Sw. , Ben-Haim E. , Bernlochner F. U. , Bona M. , Bozek A. , Bozzi C. , Brodzicka J. , Chrzaszcz M. , Dingfelder J. , Duell S. , Egede U. , Gersabeck M. , Gershon T. , Goldenzweig P. , Hayasaka K. , Hayashii H. , Johnson D. , Kenzie M. , Kuhr T. , Leroy O. , Li H.-B. , Lusiani A. , Ma H.-L. , Miyabayashi K. , Naik P. , Nanut T. , Patel M. , Pompili A. , Rama M. , Roney M. , Rotondo M. , Schneider O. , Schwanda C. , Schwartz A. J. , Shwartz B. , Serrano J. , Soffer A. , Tonelli D. , Urquijo P. , Van Kooten R. , Yelton J. 
Published: April 2021

AbstractThis paper reports world averages of measurements of b-hadron, c-hadron, and $$\tau $$
τ
-lepton properties obtained by the Heavy Flavour Averaging Group using results available through September 2018. In rare cases, significant results obtained several months later are also used. For the averaging, common input parameters used in the various analyses are adjusted (rescaled) to common values, and known correlations are taken into account. The averages include branching fractions, lifetimes, neutral meson mixing parameters, $$C\!P$$

C

P

violation parameters, parameters of semileptonic decays, and Cabibbo–Kobayashi–Maskawa matrix elements.
Simplified fast detector simulation in MadAnalysis 5
Authors: Araz Jack Y. , Fuks Benjamin , Polykratis Georgios 
Published: April 2021

AbstractWe introduce a new simplified fast detector simulator in the MadAnalysis 5 platform. The Python-like interpreter of the programme has been augmented by new commands allowing for a detector parametrisation through smearing and efficiency functions. On run time, an associated C++ code is automatically generated and executed to produce reconstructed-level events. In addition, we have extended the MadAnalysis 5 recasting infrastructure to support our detector emulator, and we provide predefined LHC detector configurations. We have compared predictions obtained with our approach to those resulting from the usage of the Delphes 3 software, both for Standard Model processes and a few new physics signals. Results generally agree to a level of about 10% or better, the largest differences in the predictions stemming from the different strategies that are followed to model specific detector effects. Equipped with these new functionalities, MadAnalysis 5 now offers a new user-friendly way to include detector effects when analysing collider events, the simulation of the detector and the analysis being both handled either through a set of intuitive Python commands or directly within the C++ core of the platform.
Exact charged black hole solutions in D-dimensions in f(R) gravity
Authors: Tang Zi-Yu , Wang Bin , Papantonopoulos Eleftherios 
Published: April 2021

AbstractWe consider Maxwell-f(R) gravity and obtain an exact charged black hole solution with dynamic curvature in D-dimensions. Considering a spherically symmetric metric ansatz and without specifying the form of f(R) we find a general black hole solution in D-dimensions. This general black hole solution can reduce to the Reissner–Nordström (RN) black hole in D-dimensions in Einstein gravity and to the known charged black hole solutions with constant curvature in f(R) gravity. Restricting the parameters of the general solution we get polynomial solutions which reveal novel properties when compared to RN black holes. Specifically we study the solution in $$(3+1)$$

(
3
+
1
)

-dimensions in which the form of f(R) can be solved explicitly giving a dynamic curvature and compare it with the RN black hole. We also carry out a detailed study of its thermodynamics.
Perihelion advance and stability criterion of a spinning charged test particle in Reissner–Nordström field: Application in earth orbit
Authors: Bakry Mohamed Abdallah , Moatimid Galal Mahrous , Tantawy Mohamed Mounir 
Published: April 2021

In this study, a new equation of motion of a spinning charged test particle is examined. This equation is a counterpart of Papapetrou equations in Riemannian geometry when the charge of the particle disappears. By using the Lagrangian approach, the equation of motion of the spinning charged particle is derived. Furthermore, the path deviation of the spinning charged particle is achieved by the same Lagrangian function. The equation of motion of the spinning charged test particle, in the Reissner–Nordström background is entirely solved. The stability criteria of the spinning motion of the charge test particle are discussed. The Perihelion advance and trajectory of a spinning charged test particle, in the Reissner–Nordström space–time, is scrutinized along with two different methods; the first is the perturbation method (Einstein’s method) and the second is described by Kerner et al.[Formula: see text] Moreover, the effect of charge and spin on Perihelion advance are inspected. Additionally, the existing results are matched with the previously cited works. Finally, applications to the Earth’s orbit are also analyzed.
Electron-impact ionization and ionic fragmentation of O2from threshold to 120 eV energy range
Authors: Lomsadze R. A. , Gochitashvili M. R. , Kezerashvili R. Ya. , Schulz M. 
Published: April 2021

We study the electron-impact induced ionization of O2from threshold to 120 eV using the electron spectroscopy method. Our approach is simple in concept and embodies the ion source with a collision chamber and a mass spectrometer with a quadruple filter as a selector for the product ions. The combination of these two devices makes it possible to unequivocally collect all energetic fragment ions formed in ionization and dissociative processes and to detect them with known efficiency. The ion source allows varying and tuning the electron-impact ionization energy and the target-gas pressure. We demonstrate that for obtaining reliable results of cross-sections for inelastic processes and determining mechanisms for the formation of O[Formula: see text] ions, it is crucial to control the electron-impact energy for production of ion and the pressure in the ion source. A comparison of our results with other experimental and theoretical data shows good agreement and proves the validity of our approach.
Risk of Atrial Fibrillation and Stroke After Bariatric Surgery in Patients With Morbid Obesity With or Without Obstructive Sleep Apnea
Authors: Dalmar Ahmed , Singh Maharaj , Heis Zoe , Cumpian Tabitha L. , Ceretto Cheryl , Mortada M. Eyman , Bhatia Atul , Niazi Imran , Chua Thomas Y. , Sra Jasbir , Jahangir Arshad 
Published: April 2021

Background and Purpose:
Weight loss in morbidly obese patients reduces atrial fibrillation (AF); however, it is unknown whether similar benefits are maintained in patients with obstructive sleep apnea (OSA). We sought to determine whether incident AF and stroke rates are affected by OSA after weight loss and to identify predictors of AF and stroke.

Methods:
Differences in laparoscopic adjustable gastric banding–induced weight loss on incident AF and stroke events in those with and without OSA in the entire and in propensity-matched cohorts were determined longitudinally, and independent predictors of AF and stroke were identified.

Results:

Of 827 morbidly obese patients who underwent laparoscopic adjustable gastric banding (mean age, 44±11 years; mean body mass index, 49±8 kg/m
2
), incident AF was documented in 4.96% and stroke in 5.44% of patients during a mean 6.0±3.2-year follow-up. Despite a similar reduction in body weight (19.6% and 21% in 3 years), new-onset AF was significantly higher in patients with OSA than without OSA in the entire (1.7% versus 0.5% per year;
P
<0.001) and propensity-matched cohorts. Incident stroke was higher in the OSA than in the non-OSA group (2.10% versus 0.47% per year;
P
<0.001), but only 20% of patients with stroke had documented AF. On multivariate analysis, OSA (hazard ratio, 2.88 [95% CI, 1.45–5.73]), age, and hypertension were independent predictors of new-onset AF, and OSA (hazard ratio, 5.84 [95% CI, 3.02–11.30]), depression, and body mass index were for stroke events.

Conclusions:
In morbidly obese patients who underwent laparoscopic adjustable gastric banding, despite similar weight loss, patients with OSA had a higher incidence of AF and stroke than patients without OSA. Both non-AF and AF-related factors were involved in increasing stroke risk. Further investigation is warranted into whether OSA treatment helps reduce AF or stroke events in this population.
Amnesic Probing: Behavioral Explanation with Amnesic Counterfactuals
Authors: Elazar Yanai , Ravfogel Shauli , Jacovi Alon , Goldberg Yoav 
Published: April 2021

AbstractA growing body of work makes use of probing in order to investigate the working of neural models, often considered black boxes. Recently, an ongoing debate emerged surrounding the limitations of the probing paradigm. In this work, we point out the inability to infer behavioral conclusions from probing results, and offer an alternative method that focuses on how the information is being used, rather than on what information is encoded. Our method, Amnesic Probing, follows the intuition that the utility of a property for a given task can be assessed by measuring the influence of a causal intervention that removes it from the representation. Equipped with this new analysis tool, we can ask questions that were not possible before, for example, is part-of-speech information important for word prediction? We perform a series of analyses on BERT to answer these types of questions. Our findings demonstrate that conventional probing performance is not correlated to task importance, and we call for increased scrutiny of claims that draw behavioral or causal conclusions from probing results.1
Playing dead: lizards show tonic immobility without human handling
Authors: Damas-Moreira Isabel 
Published: April 2021

Abstract
Tonic immobility, or the ability to play dead, is widespread among vertebrates. It is a last line of defence against a threat, and usually follows physical restraint. Here, I report two lizards exhibiting tonic immobility in the presence of humans, but remarkably, without any handling or physical contact. These two lizards belonged to an invasive population of the Italian Wall Lizard (Podarcis siculus), and both events took place in different years and situations, suggesting this behaviour may be more common than previously thought. There are rare documented cases of animals exhibiting this behaviour without handling; however, to my knowledge, this is the first description of a lizard displaying tonic immobility to humans, in the absence of handling. This is also the first incident of tonic immobility in the Italian Wall Lizard. I discuss these anecdotal events in the light of this invasive population inhabiting a highly urbanized location.
Risk Factors Associated to Residual Tumor in Re-excision for Positive Margins in Breast Conservative Surgery
Authors: Sarre-Lazcano Catherine , Clemente-Gutiérrez Uriel , Pastor-Sifuentes Francisco U. , Medina-Franco Heriberto 
Published: April 2021

Background Breast conservative surgery (BCS) is an adequate treatment for patients with early breast cancer. Local recurrence is associated with diverse factors. Our objective was to evaluate risk factors associated with finding residual tumor in patients with positive margins in BCS. Methods Observational retrospective study, including patients diagnosed with breast cancer undergoing BCS between 2000 and 2016. Clinicopathological and treatment variables were collected. Main outcome was the finding of residual tumor on re-excision. Positive margins were defined as tumor present on ink. Results Three hundred and six patients underwent BCS. Mean age was 57 ± 12.2 years. Positive margins were found in 84 (27.4%) patients, 15 (4.9%) had unknown margin status, and 207 (67.6%) had negative margins. Seventy-eight patients from the positive margin group and 23 patients from the unknown/negative margin group were reintervened. Residual tumor was present in 41% of patients with positive margins and in 45% of patients with negative margins ( P = .192). In univariate analysis, overweight (P = .04) and positive axillary lymph nodes ( P = .02) were associated with residual tumor on re-excision. In multivariate analysis, postmenopausal status was a protective factor (HR .047, P = .30). Mean follow-up was 58.4 months and mean local recurrence-free survival (LRFS) was 56.4 months (.1-203.2), with no difference regarding margin status or residual tumor. Discussion Postmenopausal status was associated with a decreased rate of residual tumor in patients with positive margins. The presence of residual tumor on re-excision was not associated with a lower LRFS. These factors must be considered when positive margins are present in BCS.
Surgical Control of Bleeding From Ovarian Torsion in the Setting of Immune Thrombocytopenic Purpura Without Splenectomy
Authors: Shaw Taylor B. , Ma Brenda , Barazza Mark , Sawaya David 
Published: April 2021

Immune thrombocytopenic purpura (ITP) is a disorder caused by autoimmune antibodies which target glycoprotein IIb/IIIa complex or other platelet membrane antigens leading to platelet destruction. These platelets are then cleared by the spleen resulting in thrombocytopenia. Immune thrombocytopenic purpura affects about 1 to 6.4 cases in 100 000 children making it one of the most common causes of symptomatic thrombocytopenia in the pediatric population. It is rare that children or adolescents present with serious bleeding due to ITP. Common presentations include petechiae, bleeding gums, or bruising. Bleeding requiring hospitalization or transfusions is unusual and only occurs in approximately 5% of children. Even more uncommon is the presentation of severe bleeding complications requiring surgery for resolution. We present a case of a 17-year-old girl with acute ITP complicated by intraperitoneal hemorrhage and refractory thrombocytopenia due to ovarian cyst requiring oophorectomy.
The Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo
Authors: Sarsitthithum Kanokporn , Wisupagan Tosapohn , Kiatthanabumrung Sivaporn , Jariengprasert Chanchai 
Published: April 2021

Objective: This study aimed to evaluate the association between serum vitamin D levels and benign paroxysmal positional vertigo (BPPV). Participants and Methods: This prospective study consisted of 137 participants. There were 69 participants in the BPPV group compared with 68 healthy participants. Blood samples from both groups were collected from all participants to assess serum vitamin D levels. Results: No significant difference in demographic data between BPPV and control groups. The results showed that the mean serum vitamin D levels in the BPPV group was lower than that of the control group ( P value = .001). Among BPPV participants, there was no statistically significant difference between mean serum vitamin D levels of participants with recurrent BPPV, and that of newly diagnosed BPPV participants ( P value = .313). Conclusion: A statistically significant association between lower mean serum vitamin D levels in the BPPV group compared with that of the control group. Therefore, low serum vitamin D levels may be one of the risk factors for BPPV.
BMI self-selection: Exploring alternatives to self-reported BMI
Authors: Shiely Frances , Millar Seán R 
Published: April 2021

Background Accurately measuring BMI in large epidemiological studies is problematic as objective measurements are expensive, so subjective methodologies must usually suffice. The purpose of this study is to explore a new subjective method of BMI measurement: BMI self-selection. Methods A cross-sectional analysis of the Mitchelstown Cohort Rescreen study, a random sample of 1,354 men and women aged 51–77 years recruited from a single primary care centre. BMI self-selection was measured by asking patients to select their BMI category: underweight, normal weight, overweight, obese. Weight and height were also objectively measured. Results 79% were overweight or obese: 86% of males, 69% of females (P < 0.001) and 59% of these underestimated their BMI. The sensitivity for correct BMI self-selection for normal weight, overweight and obese was 77%, 61% and 11% respectively. In multivariable analysis, gender, higher education levels, being told by a health professional to lose weight, and being on a diet were significantly associated with correct BMI self-selection. There was a linear trend relationship between increasing BMI levels and correct selection of BMI; participants in the highest BMI quartile had an approximate eight-fold increased odds of correctly selecting their BMI when compared to participants within the lower overweight/obese quartiles (OR = 7.72, 95%CI:4.59, 12.98). Conclusions BMI self-selection may be useful for self-reporting BMI. Clinicians need to be aware of disparities between BMI self-selection at higher and lower BMI levels among overweight/obese patients and encourage preventative action for those at the lower levels to avoid weight gain and thus reduce their all-cause mortality risk.
Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility
Authors: Bellil Hela , Ghieh Farah , Hermel Emeline , Mandon-Pepin Béatrice , Vialard François 
Published: April 2021

AbstractSpermatogenesis is a complex process regulated by a multitude of genes. The identification and characterization of male-germ-cell-specific genes is crucial to understanding the mechanisms through which the cells develop. The term “TEX gene” was coined by Wang et al. (Nat Genet. 2001; 27: 422–6) after they used cDNA suppression subtractive hybridization (SSH) to identify new transcripts that were present only in purified mouse spermatogonia. TEX (Testis expressed) orthologues have been found in other vertebrates (mammals, birds, and reptiles), invertebrates, and yeasts. To date, 69 TEX genes have been described in different species and different tissues. To evaluate the expression of each TEX/tex gene, we compiled data from 7 different RNA-Seq mRNA databases in humans, and 4 in the mouse according to the expression atlas database.Various studies have highlighted a role for many of these genes in spermatogenesis. Here, we review current knowledge on the TEX genes and their roles in spermatogenesis and fertilization in humans and, comparatively, in other species (notably the mouse). As expected, TEX genes appear to have a major role in reproduction in general and in spermatogenesis in humans but also in all mammals such as the mouse. Most of them are expressed specifically or predominantly in the testis. As most of the TEX genes are highly conserved in mammals, defects in the male (gene mutations in humans and gene-null mice) lead to infertility. In the future, cumulative data on the human TEX genes’ physiological functions and pathophysiological dysfunctions should become available and is likely to confirm the essential role of this family in the reproductive process. Thirteen TEX genes are now referenced in the OMIM database, and 3 have been linked to a specific phenotype. TEX11 (on Xq13.1) is currently the gene most frequently reported as being associated with azoospermia.
The relationship between voluntary employer change and work ability among older workers: investigating the honeymoon-hangover effect
Authors: Garthe Nina , Hasselhorn Hans Martin 
Published: April 2021

AbstractThe aim of the study was to investigate the effect of voluntary employer changes on self-reported work ability among older workers in Germany and whether a honeymoon-hangover effect (HHE) exists here. In research on job satisfaction, three typical periods around a voluntary employer change characterize a HHE: a deterioration in the old job (deterioration), an initial increase in the new job (honeymoon) and a subsequent decline over time (hangover). Whether a HHE exists in respect to work ability following a voluntary employer change remained open. The analyses are based on data from the first three waves of the lidA study (2011, 2014, 2018), a representative cohort study of older employees in Germany born in 1959 or 1965. Data from 2502 workers who participated in all three study waves was analyzed. Fixed-effects regression analyses including lag and lead variables were conducted. A deterioration, honeymoon and hangover period were found. Work ability increased substantially following the voluntary employer change. Our study shows that voluntary employer changes have the potential to maintain work ability at higher working age, but not to increase the work ability in the long-term perspective. However, despite the existence of a hangover period, the positive overall effect of the voluntary change should not be underestimated.