bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semiquantitative Risk Assessment Method for Groundwater Source Protection Using a Process-based Interdisciplinary Approach
Authors: Duda Robert , Zdechlik Robert , Kania Jarosław 
Published: July 2021

AbstractPotable groundwater resources are at risk as a result of industrial development and an increase in fertilizer use. Protection of the groundwater supply may require the establishment of groundwater source protection zones (GSPZs) to allow the implementation of protective measures. The aim of this study was to develop a new approach to groundwater source risk assessment (GSRA). The risk was defined as the highest of the risks identified for individual potential sources of contamination (PSCs). The risk resulting from a given PSC is the combination of its adverse impact on groundwater, unwanted event probability, and adverse effect and annoyance to the population. A multicriteria assessment method was designed to estimate indices of the potential groundwater impact of industrial facilities and noninert waste landfills with the range and weight method. Application of the proposed approach was tested considering an idealized model and three scenarios involving various industrial PSCs and fertilization practices. The overall nitrogen load was compared to the maximum effective nitrogen load for the crops in question. Sensitivity analysis of this methodology revealed that the main factors influencing the risk to the water supply include the nonreactive contaminant mass load in PSC leachate and the ratio of the groundwater volume abstracted from wells to the amount of water flowing from PSCs into wells, which determines the dilution degree of the contaminant mass. This proposed interdisciplinary approach to GSRA provides a robust basis to reach decisions on GSPZ establishment and the development of a groundwater risk analysis methodology.
Examining the Feasibility of Quantifying Receptor Availability Using Cross-Modality Paired-Agent Imaging
Authors: Meng Boyu , Sadeghipour Negar , Folaron Margaret R. , Strawbridge Rendall R. , Samkoe Kimberley S. , Tichauer Kenneth M. , Davis Scott C. 
Published: July 2021

Abstract
Purpose
The ability to noninvasively quantify receptor availability (RA) in solid tumors is an aspirational goal of molecular imaging, often challenged by the influence of non-specific accumulation of the contrast agent. Paired-agent imaging (PAI) techniques aim to compensate for this effect by imaging the kinetics of a targeted agent and an untargeted isotype, often simultaneously, and comparing the kinetics of the two agents to estimate RA. This is usually accomplished using two spectrally distinct fluorescent agents, limiting the technique to superficial tissues and/or preclinical applications. Applying the approach in humans using conventional imaging modalities is generally infeasible since most modalities are unable to routinely image multiple agents simultaneously. We examine the ability of PAI to be implemented in a cross-modality paradigm, in which the targeted and untargeted agent kinetics are imaged with different modalities and used to recover receptor availability.

Procedures
Eighteen mice bearing orthotopic brain tumors were administered a solution containing three contrast agents: (1) a fluorescent agent targeted to epidermal growth factor receptor (EGFR), (2) an untargeted fluorescent isotype, and (3) a gadolinium-based contrast agent (GBCA) for MRI imaging. The kinetics of all three agents were imaged for 1 h after administration using an MRI-coupled fluorescence tomography system. Paired-agent receptor availability was computed using (1) the conventional all-optical approach using the targeted and untargeted optical agent images and (2) the cross-modality approach using the targeted optical and untargeted MRI-GBCA images. Receptor availability estimates between the two methods were compared.

Results
Receptor availability values using the cross-modality approach were highly correlated to the conventional, single-modality approach (r = 0.94; p < 0.00001).

Conclusion
These results suggest that cross-modality paired-agent imaging for quantifying receptor availability is feasible. Ultimately, cross-modality paired-agent imaging could facilitate rapid, noninvasive receptor availability quantification in humans using hybrid clinical imaging modalities.
Transcriptome sequencing and drought resistance gene annotation in Quercus liaotungensis leaves
Authors: Wang Guobao , Qin Li 
Published: July 2021

AbstractQ. liaotungensis is an important drought-resistant tree species in Northeast China where the climate is dry and rainless. In this study, we performed a deep transcriptomic sequencing in Q. liaotungensis leaves, including de novo assembly and functional annotation for screening the candidate genes involved in drought avoidance. A total of 25,593 unigenes were obtained from Illumina sequencing platform. According to Gene Ontology annotation and KEGG pathway enrichment analysis, we screened a series of candidate genes encoding SOD, POD, CAT, DREB, MYB, WRKY, bZIP, and NAC from the Q. liaotungensis leaf transcriptome, all of which are potentially involved in drought resistance. The results of this study expanded the genetic resources of Q. liaotungensis and provided a theoretical basis for further exploring the functional gene information of Q. liaotungensis.
Impact of cardiovascular disease on clinical outcomes in hospitalized patients with Covid-19: a systematic review and meta-analysis
Authors: Maddaloni Ernesto , D’Onofrio Luca , Siena Antonio , Luordi Cecilia , Mignogna Carmen , Amendolara Rocco , Cavallari Ilaria , Grigioni Francesco , Buzzetti Raffaella 
Published: July 2021

AbstractContrasting data have been published about the impact of cardiovascular disease on Covid-19. A comprehensive synthesis and pooled analysis of the available evidence is needed to guide prioritization of prevention strategies. To clarify the association of cardiovascular disease with Covid-19 outcomes, we searched PubMed up to 26 October 2020, for studies reporting the prevalence of cardiovascular disease among inpatients with Covid-19 in relation to their outcomes. Pooled odds-ratios (OR) for death, for mechanical ventilation or admission in an intensive care unit (ICU) and for composite outcomes were calculated using random effect models overall and in the subgroup of people with comorbid diabetes. Thirty-three studies enrolling 52,857 inpatients were included. Cardiovascular disease was associated with a higher risk of death both overall (OR 2.58, 95% confidence intervals, CI 2.12–3.14, p < 0.001, number of studies 24) and in the subgroup of people with diabetes (OR 2.91, 95% CI 2.13–3.97, p < 0.001, number of studies 4), but not with higher risk of ICU admission or mechanical ventilation (OR 1.35, 95% CI 0.73–2.50, p = 0.34, number of studies 4). Four out of five studies reporting OR adjusted for confounders failed to show independent association of cardiovascular disease with Covid-19 deaths. Accordingly, the adjusted-OR for Covid-19 death in people with cardiovascular disease dropped to 1.31 (95% CI 1.01–1.70, p = 0.041). Among patients hospitalized for Covid-19, cardiovascular disease confers higher risk of death, which was highly mitigated when adjusting the association for confounders.
Coronary plaque instability assessed by positron emission tomography and optical coherence tomography
Authors: Galiuto L. , Leccisotti L. , Locorotondo G. , Porto I. , Burzotta F. , Trani C. , Niccoli G. , Leone A. M. , Danza M. L. , Melita V. , Fedele E. , Stefanelli A. , Giordano A. , Crea F. 
Published: July 2021

Abstract
Background
Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) are caused often by destabilization of non-flow limiting inflamed coronary artery plaques. 18F-fluorodeoxyglucose (FDG) uptake with positron emission tomography/computed tomography (PET/CT) reveals plaque inflammation, while intracoronary optical coherence tomography (OCT) reliably identifies morphological features of coronary instability, such as plaque rupture or erosion. We aimed to prospectively compare these two innovative biotechnologies in the characterization of coronary artery inflammation, which has never been attempted before.

Methods
OCT and FDG PET/CT were performed in 18 patients with single vessel coronary artery disease, treated by percutaneous coronary intervention (PCI) with stent implantation, divided into 2 groups: NSTEMI/UA (n = 10) and stable angina (n = 8) patients.

Results
Plaque rupture/erosion recurred more frequently [100% vs 25%, p = 0.001] and FDG uptake was greater [TBR median 1.50 vs 0.87, p = 0.004] in NSTEMI/UA than stable angina patients. FDG uptake resulted greater in patients with than without plaque rupture/erosion [1.2 (0.86–1.96) vs 0.87 (0.66–1.07), p = 0.013]. Among NSTEMI/UA patients, no significant difference in FDG uptake was found between ruptured and eroded plaques. The highest FDG uptake values were found in ruptured plaques, belonging to patients with NSTEMI/UA. OCT and PET/CT agreed in 72% of patients [p = 0.018]: 100% of patients with plaque rupture/erosion and increased FDG uptake had NSTEMI/UA.

Conclusion
For the first time, we demonstrated that the correspondence between increased FDG uptake with PET/CT and morphology of coronary plaque instability at OCT is high.
On Ulrich bundles on projective bundles
Authors: Hochenegger Andreas 
Published: July 2021

Abstract
In this article, the existence of Ulrich bundles on projective bundles

$${{\mathbb {P}}}({{\mathcal {E}}}) \rightarrow X$$

P
(
E
)
→
X

is discussed. In the case, that the base variety X is a curve or surface, a close relationship between Ulrich bundles on X and those on

$${{\mathbb {P}}}({{\mathcal {E}}})$$

P
(
E
)

is established for specific polarisations. This yields the existence of Ulrich bundles on a wide range of projective bundles over curves and some surfaces.
Effects of environmental factors on the behaviour and nest group sizes of Smith's bush squirrels, Paraxerus cepapi, in a Zambezian bioregion
Authors: Nyirenda Vincent R. , Sakala Sudden , Simwanda Matamyo , Phiri Darius , Murayama Yuji , Ranagalage Manjula 
Published: July 2021

AbstractThe responses of wildlife to environmental factors are of conservation importance. However, the absence of relevant information due to inadequate studies, and lack of understanding of the influences of environmental factors on wildlife, particularly in the Zambezian bioregion, remain a conservation concern. For instance, there is a shortage of knowledge on the relationship between fixed effects of environmental factors and behaviour as well as nest group sizes of Smith’s bush squirrels,Paraxerus cepapiSmith, 1836. Our study examined the relationship between fixed effects of several environmental factors (i.e., with focus on ecological factors) and the behaviour as well as nest group sizes of the bush squirrels in and around Zambia’s Chembe Bird Sanctuary (CBS). Flight initiation distances (FIDs) as an index of bush squirrel behaviour, and nest group sizes were simultaneously surveyed to understand the drivers of biological and population responses, respectively. The results revealed that higher tree height (m) and larger canopy coverage (%) could increase FIDs for bush squirrels. The nest group sizes of bush squirrels could also increase with canopy coverage (%) and presence of termite mounds. By focusing on the two different squirrels' responses, the results of this study highlight the most important environmental factors to consider in minimizing the impacts of human activities on bush squirrels, especially in conservation planning and management by taking into consideration the bush squirrels’ natural history, habitat protection and safe distance between humans and bush squirrels.
Seizures as the first manifestation of chromosome 2q24.2-q24.3 in a two and a half years old girl: A case report
Authors: Dai Wen-cheng , Liu Xue-xia , Li Hui-jun , Song Gui-ning , Li Yan-hui , Zhang Cheng-ling , Zhang Lin 
Published: July 2021

AbstractBackgroundMutations and/or duplications in the chromosome 2q24.3 region are known to be responsible for various epilepsy phenotypes. However, microdeletion in childhood epilepsy is rarely reported.Case presentationA two-and-a-half-year-old girl with no history of hypocalcemia or seizures developed new symptoms of generalized tonic-clonic epilepsy. The clinical manifestations were growth retardation, prominent forehead, closed anterior fontanelle, and poor muscle tension. Peripheral blood, echocardiography, abdominal ultrasound, and electroencephalogram (EEG) examinations were all normal. No karyotype abnormality was found in the patient, but a single nucleotide polymorphism (SNP) array test detected that a 3.5 Mb single-copy microdeletion had occurred in the q24.2-q24.3 region on chromosome 2. Fluorescence in situ hybridization (FISH) tests revealed that the 2q24 fragment was inserted into the q11.2 region of the patient's chromosome 15, as well as that of her sister. In both cases, the patient's mother is the source carrier of the chromosome 15 insertion.ConclusionsThe deletion of the sodium channel gene cluster (SCN1A, SCN2A, and SCN3A), but not SCN1A haploinsufficiency ​alone, may contribute to complex infant epilepsy syndromes. However, the pathogenic mechanism still needs to be studied further.
Storm Time Effects on Latitudinal Distribution of Ionospheric TEC in the American and Asian‐Australian Sectors: August 25–26, 2018 Geomagnetic Storm
Authors: Bolaji O. S. , Fashae J. B. , Adebiyi S. J. , Owolabi Charles , Adebesin B. O. , Kaka R. O. , Ibanga Jewel , Abass M. , Akinola O. O. , Adekoya B. J. , Younas W. 
Published: July 2021

AbstractOn the dayside of August 25–26, 2018 (main phase, MP of the storm), we unveiled the storm time effects on the latitudinal distribution of ionospheric total electron content (TEC). We used 17 and 19 Global Positioning System receivers in American and Asian‐Australian sectors, respectively. Also, we employed a pair of magnetometers in each sector to unveil storm time effects on vertical E × B upward directed inferred drift velocity in the F region ionosphere. Also used is NASA Thermosphere Ionosphere Mesosphere Energetics and Dynamics satellite airglow instrument to investigate storm time changes in neutral composition, O/N2 ratio. In this investigation, we corrected the latitudinal offset found in the works of Younas et al. (2020, https://doi.org/10.1029/2020JA027981). Interestingly, we observed that a double‐humped increase (DHI) seen at a middle latitude station (MGUE, ∼22°S) after the MP on the dayside in American sector (Younas et al., 2020, https://doi.org/10.1029/2020JA027981) did straddle ∼23.58°N and ∼22°S. On August 25, 2018, storm commencement was evident in Sym‐H (∼−8 nT) around 18:00 UT. It later became intensified (∼−174 nT) on August 26 around 08:00 UT. During storm's MP (after the MP), fountain effect operation was significantly enhanced (inhibited) in Asian‐Australian (American) sector. Middle latitude TEC during MP got reduced in American sector (13:00 LT–15:40 LT) compared to those seen in Asian‐Australian sector (13:00 LT–15:40 LT). The northern equatorial peak (∼25 TECU) seen at IHYO (14:00 LT) after MP in the American sector is higher when compared with that (∼21 TECU) seen at PPPC (11:40 LT) during MP in Asian‐Australian sector.
Inferring Permafrost Active Layer Thermal Properties From Numerical Model Optimization
Authors: de Bruin Jelte G. H. , Bense Victor F. , van der Ploeg Martine J. 
Published: July 2021

AbstractPermafrost has become increasingly unstable as a result of surface warming; therefore it is crucial to improve our understanding of permafrost spatiotemporal dynamics to assess the impact of active layer thickening on future hydrogeological processes. However, direct determinations of permafrost active‐layer thermal properties are few, resulting in large uncertainty in forecasts of active layer thickness. To assess how to reduce the uncertainty without expanding monitoring efforts, a total of 1,728 numerical 1D models were compared using three error measures against observed active layer temperature data from the Qinghai‐Tibetan Plateau. Resulting optimized parameter values varied depending on the error measure used, but agree with reported ones: bulk volumetric heat capacity is 1.82–1.94 K, bulk thermal conductivity 1.0–1.2 W/m K and porosity 0.25–0.45 . The active layer thickening rate varied significantly for the three error measures, as demonstrated by a years thawing time‐lag between the error measures over a 100 years modeling period.
Directionality of the Martian Surface Radiation and Derivation of the Upward Albedo Radiation
Authors: Guo Jingnan , Khaksarighiri Salman , Wimmer‐Schweingruber Robert F. , Hassler Donald M. , Ehresmann Bent , Zeitlin Cary , Löffler Sven , Matthiä Daniel , Berger Thomas , Reitz Günther , Calef Fred 
Published: July 2021

AbstractSince 2012 August, the Radiation Assessment Detector (RAD) on the Curiosity rover has been characterizing the Martian surface radiation field which is essential in preparation for future crewed Mars missions. RAD observed radiation dose is influenced by variable topographical features as the rover traverses through the terrain. In particular, while Curiosity was parked near a butte in the Murray Buttes area, we find a decrease of the dose rate by (5 1)% as 19% of the sky was obstructed, versus 10% in an average reference period. Combining a zenith‐angle‐dependent radiation model and the rover panoramic visibility map leads to a predicted reduction of the downward dose by 12% due to the obstruction, larger than the observed decrease. With the hypothesis that this difference is attributable to albedo radiation coming from the butte, we estimate the (flat‐terrain) albedo radiation to be about 19% of the total surface dose.
Field‐Aligned Low‐Energy O+ Flux Enhancements in the Inner Magnetosphere Observed by Arase
Authors: Nosé M. , Matsuoka A. , Miyoshi Y. , Asamura K. , Hori T. , Teramoto M. , Shinohara I. , Hirahara M. 
Published: July 2021

AbstractThe present study examines the low‐energy ion flux variations observed by the Arase satellite in the inner magnetosphere. From the magnetic field and ion flux data obtained by the fluxgate magnetometer and the low‐energy particle experiments–ion mass analyzer onboard Arase, we find 55 events of the low‐energy O+ flux enhancement accompanied with magnetic field dipolarization in the periods of April 1–October 31, 2017 and July 1, 2018–January 31, 2019. The low‐energy O+ flux enhancements (a) start a few minutes after the dipolarization onset, (b) have energy‐dispersed signatures with decreasing energy from a few keV down to ∼10 eV, (c) are observed in both storm and non‐storm periods, (d) have a field‐aligned distribution (α ∼ 0° in the southern hemisphere and α ∼ 180° in the northern hemisphere), (e) are accompanied by the low‐energy H+ flux enhancements that have lower energies than O+ by a factor of 3–10, and (f) increase the O+ density and the O+/H+ density ratio by ∼10 times and 4–5 times, respectively. We perform a numerical simulation to trace ion trajectories forward in time from the Arase positions. It is revealed that both H+ and O+ ions drift eastward and reach the dawn‐to‐morning sector without being lost in the ionosphere, if the pitch angle scattering effect is considered near the equatorial plane. This result suggests that these low‐energy field‐aligned ions can contribute to formation of the warm plasma cloak.
Cluster After 20 Years of Operations: Science Highlights and Technical Challenges
Authors: Escoubet C. P. , Masson A. , Laakso H. , Goldstein M. L. , Dimbylow T. , Bogdanova Y. V. , Hapgood M. , Sousa B. , Sieg D. , Taylor M. G. G. T. 
Published: July 2021

AbstractThe Cluster mission was the first constellation using four identical spacecraft to study Sun‐Earth connection plasma processes. Using four spacecraft in a tetrahedron shape, it could measure, for the first time, 3D quantities such as electrical currents, plasma gradients or divergence of the electron pressure tensor and 3D structures such as boundaries, surface waves or vortices. Launched in pairs in July and August 2000, on two Soyuz rockets from Baikonur, the four spacecraft have been collecting data continuously for more than 20 years. The mission faced many challenges during the years of operations as some spacecraft subsystems had a lifetime of a few years beyond the initial two‐year mission. The major one was to operate without functioning batteries and to successfully pass short and long eclipses, up to 3 h long, without damaging the on‐board computers and transmitters and without freezing the fuel. More than 1,000 eclipses have been successfully passed since 2010 using a specially made procedure which switches off the complete spacecraft before entering into eclipse and switches it on when the Sun is again illuminating the solar panels. During 20 years, many discoveries and science results have been published in more than 2,700 scientific papers. A few highlights are presented here, focusing on how varying the spacecraft separation was essential to achieve the science goals of the mission. The Cluster Science Data System and the Cluster archive allows public access to all science data as well as spacecraft ancillary data.
Superposed Epoch Analysis of Dispersionless Particle Injections Inside Geosynchronous Orbit
Authors: Motoba T. , Ohtani S. , Gkioulidou M. , Ukhorskiy A. Y. , Lanzerotti L. J. , Claudepierre S. G. 
Published: July 2021

AbstractDispersionless injections, involving sudden, simultaneous flux enhancements of energetic particles over some broad range of energy, are a characteristic signature of the particles that are experiencing a significant acceleration and/or rapid inward transport at the leading edge of injections. We have statistically analyzed data from Van Allen Probes (also known as Radiation Belt Storm Probes [RBSP]) to reveal where the proton (H+) and electron (e–) dispersionless injections occur preferentially inside geosynchronous orbit and how they develop depending on local magnetic field changes. By surveying measurements of RBSP during four tail seasons in 2012–2019, we have identified 171 dispersionless injection events. Most of the events, which are accompanied by local magnetic dipolarizations, occur in the dusk‐to‐midnight sector, regardless of particle species. Out of the selected 171 events, 75 events exhibit dispersionless injections of both H+ and e–, which occur within 2 min of each other. With only three exceptions, the both‐species injection events are further divided into two main subgroups: One is the H+ preceding e– events with a time offset of tens of seconds between H+ and e–, and the other the concurrent H+ and e– events without any time offset. Our superposed epoch results raise the intriguing possibility that the presence or absence of a pronounced negative dip in the local magnetic field ahead of the concurrent sharp dipolarization determines which of the two subgroups will occur. The difference between the two subgroups may be explained in terms of the dawn‐dusk asymmetry of localized diamagnetic perturbations ahead of a deeply penetrating dipolarization front.