bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of rapid rupture of a calcified amorphous tumor observed by echocardiography
Authors: Shirakura Kentaro , Ushioda Ryohei , Tsutsui Masahiro , Kunioka Shingo , Mochizuki Nobuhiro , Aonuma Tatsuya , Kawabata Naoko , Saitoh Erika , Nakagawa Naoki , Kamiya Hiroyuki 
Published: February 2025

Abstract
A calcified amorphous tumor (CAT) of the heart is a rare, non-neoplastic, intracavitary cardiac mass. Histological examination reveals the presence of calcified and amorphous fibrous material with underlying chronic inflammation. Some studies have reported that CAT typically exhibits rapid growth. However, we observed a case in which CAT unexpectedly ruptured within approximately two weeks. There was no cerebral infarction or significant valvular disease, therefore we were not sure about the indication for surgery; however considering the epidemiological possibility of CAT, we decided to operate and were able to treat the patient without complications.
Discovery of the variable optical counterpart of the redback pulsar PSR J2055+1545
Authors: Sen Marco Turchetta Bidisha , Simpson Jordan A , Linares Manuel , Breton Rene P , Casares Jorge , Kennedy Mark R , Shahbaz Tariq 
Published: February 2025

Abstract
We present the discovery of the variable optical counterpart to PSR J2055+1545, a redback millisecond pulsar, and the first radial velocity curve of its companion star. The multi-band optical light curves of this system show a 0.4–0.6 mag amplitude modulation with a single peak per orbit and variable colours, suggesting that the companion is mildly irradiated by the pulsar wind. We find that the flux maximum is asymmetric and occurs at orbital phase ≃ 0.4, anticipating the superior conjunction of the companion (where the optical emission of irradiated redback companions is typically brightest). We ascribe this asymmetry, well fit with a hot spot in our light curve modelling, to irradiation from the intrabinary shock between pulsar and companion winds. The optical spectra obtained with the Gran Telescopio Canarias reveal a G-dwarf companion star with temperatures of 5749 ± 34 K and 6106 ± 35 K at its inferior and superior orbital conjunctions, respectively, and a radial velocity semi-amplitude of 385 ± 3 km s−1. Our best-fit model yields a neutron star mass of $1.7^{+0.4}_{-0.1} \ \mathrm{M}_{\odot }$ and a companion mass of $0.29^{+0.07}_{-0.01} \ \mathrm{M}_{\odot }$. Based on the close similarity between the optical light curve of PSR J2055+1545 and those observed from PSR J1023+0038 and PSR J1227−4853 during their rotation-powered states, we suggest this system may develop an accretion disc in the future and manifest as a transitional millisecond pulsar.
Phase 1 dose-escalation trial using convection-enhanced delivery (CED) of radio-immunotheranostic 124I-Omburtamab for diffuse intrinsic pontine glioma (DIPG)
Authors: Souweidane Mark M , Bander Evan D , Zanzonico Pat , Reiner Anne S , Manino Nicole , Haque Sofia , Carrasquillo Jorge A , Lyashchenko Serge K , Thakur Sunitha B , Lewis Jason S , Donzelli Maria , Cheung Nai-Kong V , Larson Steven M , Kramer Kim , Pandit-Taskar Neeta , Dunkel Ira J 
Published: February 2025

Abstract

Background
Median survival for patients with Diffuse Intrinsic Pontine Glioma (DIPG) is 8-12 months.

Methods
A phase 1, open label, 3 + 3 dose escalation trial delivered radiolabeled 124I-Omburtamab, targeting B7-H3, using MR-guided stereotactic convection enhanced delivery (CED) into the brainstem of pediatric DIPG patients. CED was performed after completion of standard-of-care external-beam radiation therapy (EBRT). Fifty children were treated and evaluable. 124I-Omburtamab activity was escalated from 0.25-10.0 mCi (9.25-370 MBq) and volume escalated from 0.25 ml-10.0 ml with serial PET/MRI post-administration. Safety was the primary outcome. National Cancer Institute Common Terminology Criteria for Adverse Events were assessed for 30 days following CED of 124I-Omburtamab. Secondary outcomes included overall survival and lesion-to-whole-body absorbed dose ratio.

Results
The maximum tolerated activity per study protocol was determined to be 6mCi (222 MBq). The overall mean (±SD) total absorbed dose in the lesion per unit injected activity was 35.2 ± 18 cGy/MBq with a high lesion-to-whole-body absorbed dose ratio averaging 816, across all activity levels. Eleven patients had treatment-related grade 3 CNS toxicities with no grade-4 or -5 CNS toxicities. Five dose-limiting toxicity events occurred. Median survival was 15.29 months from diagnosis (95% CI: 12.20 – 16.83 months). Survival rate estimates at 1, 2, and 3 years were 65.4% (CI 53.3-80.1%), 18.4% (CI: 10.2-33.2%), and 11.7% (CI: 5.3-25.7%), respectively.

Conclusions
Administration of 124I-Omburtamab via CED is a safe treatment option for DIPG, with a maximum tolerated activity level identified. This study represents the first in-human theranostic use of a 124I radiopharmaceutical, simultaneously, as an imaging and therapeutic agent.
Content analysis of tobacco brands’ “Tagged” section on Instagram
Authors: Donaldson Scott I , La Capria Kathryn , DeJesus Amanda , Ganz Ollie , Allem Jon-Patrick 
Published: February 2025

Abstract

Introduction
Brands can be “tagged” in Instagram posts to communicate a partnership with a social media influencer. Little is known about the content of these communications in the tobacco-related literature. To address this gap, this study identified tagged posts on the official Instagram pages of tobacco brands and described the themes of such posts.

Methods
Six tobacco brands with official Instagram pages were identified. Each tagged section of the brand’s official Instagram page was examined to identify potential partnerships with social media influencers. Posts to the tagged section of the Instagram page were collected from November 2022 to February 2024. For each post, tobacco-related themes were coded.

Results
This study identified 594 tagged posts from 222 potential social media influencers. The most common theme among tagged posts was product presence (n=430, 72.4%), followed by branding (n=421, 70.9%). Young adults were identified in 40.4% (n=240) of posts. Among users who tagged a brand account, 96.1% (n=571) of their account profiles contained URL links to commercial websites, suggesting social media influencer status.

Conclusions
This study showed that the tagged section of tobacco brands’ Instagram pages contained posts suggestive of paid partnerships between the brand and social media influencers. These posts often featured tobacco use and young adults. Future research should examine whether the presence of (or accessibility to) URL links to commercial websites appearing on influencers’ pages increases an Instagram user’s purchase intentions and tobacco use initiation.

Implications
This study showed that the “tagged” sections of the official Instagram pages of six tobacco brands featured tobacco use, contained links to commercial websites, avoided content about addiction, and revealed that social media influencers inconsistently disclosed financial relationships with tobacco brands. In addition to enforcing and bolstering online marketing restrictions, prevention programs and interventions may focus on tobacco-related digital media literacy to help inoculate young adults against the pro-tobacco online environment.
Social Media Use and Exposure to E-Cigarette Content: A Comparison of Lesbian or Gay, Bisexual, and Questioning and Heterosexual Male and Female Young Adults in California
Authors: Ganz Ollie , Gonsalves Nishi , Talbot Eugene M , Donaldson Scott I , Jeong Michelle , Allem Jon-Patrick 
Published: February 2025

Abstract

Introduction
Given the rapidly changing media landscape and popularity of e-cigarettes among young adults who identify as lesbian or gay, bisexual, questioning, or something else (LGB+), timely data on media consumption and exposure to e-cigarette content across media channels is imperative for developing counter-messaging and public education campaigns for these individuals.

Methods
Using 2023 data from young adults in California, this study examined how social media use differed for heterosexual and LGB+ young adults, by sex. Exposure to e-cigarette content across media channels was also compared between heterosexual and LGB+ young adults, by sex.

Results
Findings from a non-probability representative sample of young adults in California showed that more LGB+ young adults reported using Tumblr and fewer reported using Facebook and Snapchat, compared with heterosexual young adults, among both males and females. Use of Reddit was more common among LGB+ versus heterosexual females, but there were no differences by sexual identity among males. Exposure to e-cigarette marketing was more common among LGB+ females compared with heterosexual females, but this was not the case for males. Exposure to user-generated e-cigarette content, and self-reported visits to e-cigarette websites, were more common among LGB+ females compared to heterosexual females.

Conclusions
These findings highlight the importance of treating LGB+ individuals as a heterogeneous group. As such, anti-tobacco campaigns targeting LGB+ individuals that leverage social media will want to consider which platforms are most used among their target audience to increase campaign reach.

Implications
This study builds upon the literature by providing timely data on how LGB+ young adults consume social media and are exposed to e-cigarette marketing. Findings have implications for tobacco education campaigns designed for LGB+ individuals that leverage social media.
CHANGE in Cigarette, other tobacco product, and cannabis use among individuals who used or did not use CANNABIS during a smoking cessation trial
Authors: Lambart Leah M , Cox Lisa Sanderson , Mayo Matthew S , Brown Alexandra R , Leavens Eleanor L S , Ahluwalia Jasjit S , Nollen Nicole L 
Published: February 2025

Abstract

Introduction
As many as 40% of adults who smoke (AWS) use cannabis, yet little is known about how cigarette-cannabis (CIG-CAN) use impacts change in cigarette and other tobacco product (OTP) use during a quit attempt.

Methods
Secondary data analysis of a smoking cessation randomized clinical trial (RCT) that enrolled 392 Black adults who wanted to quit cigarettes and were provided 18 weeks of standard or adapted pharmacotherapy. Participants self-reported cigarettes, cannabis, and OTP at W0,2,6,12,18, and 26. Longitudinal modeling of group, time, and group by time effects compared change in cigarettes, cannabis, and OTP between those who did and did not use cannabis.

Results
Nearly half (47.2%,185/392) were CIG-CAN users. Cannabis types were joints (78.4%) and blunts (51.9%). Significant reduction in CPD over time (p=0.02) did not differ by group (p=0.18). OTP had significant group, group by time interaction and time effect (p&lt;0.001), however, OTP use is small and had minimal effect on consumption. CIG-CAN increased cannabis use through week 26 (p&lt;0.001). When CPD decreased, there was a compensatory effect on OTP (&lt;.0001), but not cannabis (p=0.37).

Conclusion
Prevalence of cannabis use was high among Black adults attempting to quit cigarette smoking in an RCT. OTP use was minimal, but CIG-CAN maintained higher OTP and increased consumption of cannabis while having similar reductions in CPD. Findings require replication in a prospectively designed study but suggest a pattern of compensation, primarily with cannabis, among CIG-CAN that may limit potential health benefit of cigarette reduction and could compromise future attempts at cessation.

Implications
This study’s findings suggest a large percentage of cannabis use (47%) and within those users an increase of other tobacco products. At the same time, participants reduced cigarettes per day in both those who did and did not use cannabis. These findings reinforce the need for targeted treatment of all combustible products. Clinical practice guidelines and empirically informed interventions to address CIG-CAN co-use are absent in the field and urgently needed. In addition, better assessment of CIG-CAN in clinical studies is needed to aid in understanding the health impact of co-use.
Large-scale analysis of fact-checked stories on Twitter reveals graded effects of ambiguity and falsehood on information reappearance
Authors: Kauk Julian , Kreysa Helene , Schweinberger Stefan R 
Published: February 2025

Abstract
Misinformation disrupts our information ecosystem, adversely affecting individuals and straining social cohesion and democracy. Understanding what causes online (mis)information to (re)appear is crucial for fortifying our information ecosystem. We analyzed a large-scale Twitter (now “X”) dataset of about 2 million tweets across 123 fact-checked stories. Previous research suggested a falsehood effect (false information reappears more frequently) and an ambiguity effect (ambiguous information reappears more frequently). However, robust indicators for their existence remain elusive. Using polynomial statistical modeling, we compared a falsehood model, an ambiguity model, and a dual effect model. The data supported the dual effect model (13.76 times as likely as a null model), indicating both ambiguity and falsehood promote information reappearance. However, evidence for ambiguity was stronger: the ambiguity model was 6.6 times as likely as the falsehood model. Various control checks affirmed the ambiguity effect, while the falsehood effect was less stable. Nonetheless, the best-fitting model explained &lt;7% of the variance, indicating that (i) the dynamics of online (mis)information are complex and (ii) falsehood effects may play a smaller role than previous research has suggested. These findings underscore the importance of understanding the dynamics of online (mis)information, though our focus on fact-checked stories may limit the generalizability to the full spectrum of information shared online. Even so, our results can inform policymakers, journalists, social media platforms, and the public in building a more resilient information environment, while also opening new avenues for research, including source credibility, cross-platform applicability, and psychological factors.
Emerging roles of RNA N4-acetylcytidine modification in reproductive health
Authors: Wubulikasimu Zibaguli , Zhao Hongyu , Mao Fengbiao , Zhao Xiaolu 
Published: February 2025

Abstract
N4-acetylcytidine (ac4C), an emerging post-transcriptional RNA modification, plays a pivotal role in epigenetic regulation. Ac4C is detected not only in tRNA, rRNA and mRNA, but also in miRNA, lncRNA, viral RNA, and even DNA. Functionally, ac4C stabilizes mRNA, enhances protein translation fidelity, and impacts various biological processes and diseases such as cancer, inflammation, immune regulation, neural diseases, osteogenic differentiation, cardiovascular diseases, viral infections, and replication. Current research primarily focuses on ac4C’s roles in cancer progression and immunity, with emerging findings in gynecological diseases and reproduction. However, a comprehensive understanding of ac4C's implications in reproductive health is lacking. This review provides a historical perspective on ac4C's discovery and detection methods, elucidates its functions in reproductive development and gynecological disorders, and offers insights for further research in reproductive health. This review aims to pave the way for innovative therapeutic approaches and precise diagnostic tools tailored to this field.
The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population
Authors: Karacam Dogan (Melike Karaçam Doğan) Melike , Prachason Thanavadee , Lin Bochao , Pries Lotta-Katrin , Arias-Magnasco Angelo , Bortoletto Riccardo , Menne-Lothmann Claudia , Decoster Jeroen , van Winkel Ruud , Collip Dina , Delespaul Philippe , De Hert Marc , Derom Catherine , Thiery Evert , Jacobs Nele , van Os Jim , Rutten Bart , Brondino Natascia , Colizzi Marco , Luykx Jurjen , Fusar-Poli Laura , Guloksuz Sinan 
Published: February 2025

Abstract

Background
Psychosis-related environmental risks in autism, along with genetic overlaps between autism and psychosis, have been well-established. However, their moderating roles in the relationship between autistic traits (ATs) and psychotic experiences (PEs) remain underexplored.

Methods
First-wave data from 792 twins and siblings (mean age: 17.47±3.6, 60.23% female) in the TwinssCan Project were analyzed. PEs and ATs were assessed using the Community Assessment of Psychic Experiences and the Autism-Spectrum Quotient, respectively. Polygenic risk scores for schizophrenia and psychosis-associated environmental factors (i.e., childhood trauma(CT), bullying, negative life events, obstetric complications, cannabis use, winter birth, and hearing impairment) were tested for their independent effects on PEs and their interaction effects with ATs in moderating the relationship between ATs and PEs using separate multilevel linear regression models with Bonferroni’s correction.

Results
ATs, all CT subtypes, bullying, and negative life events were positively associated with PEs (all P&lt;0.004). Moderation analyses revealed that the association between ATs and PEs was amplified by emotional abuse (B:0.08, 95% CI:0.05-0.11, P&lt;0.001), physical abuse (B:0.11, P=0.001), sexual abuse (B:0.09, 95% CI:0.03-0.15, P=0.002), and physical neglect (B:0.06, 95% CI:0.03-0.10, P=0.001), emotional neglect (B:0.04, 95% CI:0.01-0.07, P=0.007), and negative life events (B:0.007, 95% CI:0.0005-0.014, P=0.04), although the latter two risks did not survive Bonferroni’s correction. No significant main or interacting effects of genetic and other risk factors were found.

Conclusions
People with high ATs were more likely to have PEs when exposed to CT. Trauma screening and early interventions might be warranted in this at-risk population.
Fine root respiration in Quercus rubra (L.) aligns with the economics trade-offs in bi-dimensional root trait space
Authors: Shedd E L , Cavaleri M A , Külheim C , Burton A J 
Published: February 2025

Abstract
Plant economic theory argues that growth strategies maximize either the rate or longevity of return per resource investment in a unidimensional trade-off. Belowground trade-offs may not mimic those aboveground due to soil resource heterogeneity, different physical constraints imposed by the shape of roots compared to leaves, and fungal symbioses, and often multiple dimensions of variation are found. Root respiration represents a substantial carbon flux out of forest ecosystems, but its placement in these trade-offs is unclear, and its incorporation into carbon cycle models is limited by available data. Most research on root traits has focused on interspecific variability, but here, we investigated whether trade-offs among one species’ populations align with those between species by sampling Quercus rubra populations along a Midwest, USA latitudinal gradient. Across populations, we assessed whether fine root traits follow uni- or multidimensional trade-offs, and how these axes relate to root respiration. Respiration rates, morphological traits, and root nitrogen were measured on excised fine roots at 14 sites, spanning a wide variety of environmental conditions, and then analyzed for trade-off axes. We uncovered substantial root trait variation among Q. rubra populations that aligned with two distinct trade-offs, one between branching intensity and average diameter, and a second with root tissue density on one end and specific root length, root nitrogen concentration, and root specific respiration on the other. Reliance on ectomycorrhizal fungi, which colonize root tips, may be a possible explanation for the first axis, with higher branching intensity representing more collaboration. Along the latter axis, root specific respiration increased with root nitrogen concentration and decreased with root tissue density. These results support a similar bi-dimensional trait space between Q. rubra populations to that between species, with an economics trade-off that might be a useful predictor of the fine root respiration carbon flux.
Challenges in assessing the impact of infection and disease control interventions over the past decade based on the Expanded Special Project for the Elimination of Neglected Topical Diseases (ESPEN) database
Authors: Ng Chi Wai , Maddren Rosie , Anderson Roy M 
Published: February 2025

Abstract
Over the past 2 decades there has been good progress in the control of many of the neglected tropical diseases (NTDs) treatable by preventative chemotherapy (PC). Continued major drug donations from pharmaceutical companies, support from philanthropic organizations and heightened international recognition of the health impacts of these diseases have each played an important role in lowering the global health burden due to NTDs. However, considerable improvement in data collection is required to accurately assess this progress as we move towards the ‘end game’ of eliminating these infections as a source of morbidity and mortality. The data quality, type and format collected by the Expanded Special Project for the Elimination of Neglected Tropical Diseases database from the African Ministries of Health are discussed and suggestions made for improvements in collection and presentation.
Dipeptidyl peptidase‐4 deficiency prevents chronic stress‐induced cardiac remodeling and dysfunction in mice
Authors: Jiang Zhe , Zhao Longguo , Xin Minglong , Wan Ying , Xu Shengnan , Yue Xueling , Jin Xianglan , Cui Rihua , Li Yanglong , Kim Weon , Wu Hongxian , Cheng Xian Wu 
Published: February 2025

AbstractExposure to chronic psychosocial stress is a risk factor for metabolic cardiovascular disorders. Dipeptidyl peptidase‐4 (DPP‐4) plays essential roles in human pathobiology, and we recently showed that DPP‐4 levels are increased by chronic stress in murine models. We here investigated the role of DPP‐4 in stress‐related cardiac injury and dysfunction in mice, focusing on oxidative stress and cardiac apoptosis. Male mice were randomly assigned to non‐stress and two‐week immobilized‐stress groups for biological and morphological studies. On day 14 post‐stress, stress had increased blood pressure, heart weight, cardiac myocyte size, and interstitial fibrosis, impaired cardiac diastolic function, and increased plasma levels of DPP‐4 and glucose. The stressed mice also had increased levels of monocyte chemoattractant protein‐1, inteleukin‐6, gp91phox, matrix metalloproteinase‐2 (MMP‐2), MMP‐9, tissue inhibitor of MMP‐1/−2, caspase‐8, and Bax genes and/or proteins and lowered levels of Bcl‐2, p‐Akt, and endothelial nitric oxide synthase (eNOS) proteins. DPP‐4 inhibition by either a genetic or pharmacological approach ameliorated the stress‐induced targeted molecular and morphological changes. In vitro, DPP‐4 inhibition also mitigated the alterations in the targeted caspase‐8, Bcl‐2, eNOS, and p‐Akt proteins in H9c2 cardiomyocytes in response to H2O2. DPP‐4 inhibition appeared to improve the stress‐induced cardiac injury and dysfunction in mice, possibly via the improvement of oxidative stress and apoptosis, suggesting that DPP‐4 could become a novel therapeutic target for chronic psychological stress‐related metabolic cardiovascular disorders.