bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Classification of Glioma Subgroup, Which Is Highly Correlated With the Clinical Characteristics and Tumor Tissue Characteristics, Based on the Expression Levels of Gβ and Gγ Genes
Authors: Cai Zehao , Yu Chunna , Li Shenglan , Wang Can , Fan Yaqiong , Ji Qiang , Chen Feng , Li Wenbin 
Published: June 2021

PurposeGlioma is a classical type of primary brain tumors that is most common seen in adults, and its high heterogeneity used to be a reference standard for subgroup classification. Glioma has been diagnosed based on histopathology, grade, and molecular markers including IDH mutation, chromosome 1p/19q loss, and H3K27M mutation. This subgroup classification cannot fully meet the current needs of clinicians and researchers. We, therefore, present a new subgroup classification for glioma based on the expression levels of Gβ and Gγ genes to complement studies on glioma and Gβγ subunits, and to support clinicians to assess a patient’s tumor status.MethodsGlioma samples retrieved from the CGGA database and the TCGA database. We clustered the gliomas into different groups by using expression values of Gβ and Gγ genes extracted from RNA sequencing data. The Kaplan–Meier method with a two-sided log-rank test was adopted to compare the OS of the patients between GNB2 group and non-GNB2 group. Univariate Cox regression analysis was referred to in order to investigate the prognostic role of each Gβ and Gγ genes. KEGG and ssGSEA analysis were applied to identify highly activated pathways. The “estimate” package, “GSVA” package, and the online analytical tools CIBERSORTx were employed to evaluate immune cell infiltration in glioma samples.ResultsThree subgroups were identified. Each subgroup had its own specific pathway activation pattern and other biological characteristics. High M2 cell infiltration was observed in the GNB2 subgroup. Different subgroups displayed different sensitivities to chemotherapeutics. GNB2 subgroup predicted poor survival in patients with gliomas, especially in patients with LGG with mutation IDH and non-codeleted 1p19q.ConclusionThe subgroup classification we proposed has great application value. It can be used to select chemotherapeutic drugs and the prognosis of patients with target gliomas. The unique relationships between subgroups and tumor-related pathways are worthy of further investigation to identify therapeutic Gβγ heterodimer targets.
Combination of Decitabine and a Modified Regimen of Cisplatin, Cytarabine and Dexamethasone: A Potential Salvage Regimen for Relapsed or Refractory Diffuse Large B-Cell Lymphoma After Second-Line Treatment Failure
Authors: Hu Junxia , Wang Xin , Chen Fei , Ding Mengjie , Dong Meng , Yang Wanqiu , Yin Meifeng , Wu Jingjing , Zhang Lei , Fu Xiaorui , Sun Zhenchang , Li Ling , Wang Xinhua , Li Xin , Guo Shuangshuang , Zhang Dianbao , Lu Xiaohui , Leng Qing , Zhang Mingzhi , Zhu Linan , Zhang Xudong , Chen Qingjiang 
Published: June 2021

ObjectiveThe prognosis for patients with relapsed or refractory diffuse large B-cell lymphoma (R/R-DLBCL) after second-line treatment failure is extremely poor. This study prospectively observed the efficacy and safety of decitabine with a modified cisplatin, cytarabine, and dexamethasone (DHAP) regimen in R/R-DLBCL patients who failed second-line treatment.MethodsTwenty-one R/R-DLBCL patients were enrolled and treated with decitabine and a modified DHAP regimen. The primary endpoints were overall response rate (ORR) and safety. The secondary endpoints were progression-free survival (PFS) and overall survival (OS).ResultsORR reached 50% (complete response rate, 35%), five patients (25%) had stable disease (SD) with disease control rate (DCR) of 75%. Subgroup analysis revealed patients over fifty years old had a higher complete response rate compared to younger patients (P = 0.005), and relapsed patients had a better complete response rate than refractory patients (P = 0.031). Median PFS was 7 months (95% confidence interval, 5.1-8.9 months). Median OS was not achieved. One-year OS was 59.0% (95% CI, 35.5%-82.5%), and two-year OS was 51.6% (95% confidence interval, 26.9%-76.3%). The main adverse events (AEs) were grade 3/4 hematologic toxicities such as neutropenia (90%), anemia (50%), and thrombocytopenia (70%). Other main non-hematologic AEs were grade 1/2 nausea/vomiting (40%) and infection (50%). No renal toxicity or treatment-related death occurred.ConclusionDecitabine with a modified DHAP regimen can improve the treatment response and prognosis of R/R-DLBCL patients with good tolerance to AEs, suggesting this regimen has potential as a possible new treatment option for R/R-DLBCL patients after second-line treatment failure.Clinical Trial RegistrationClinicalTrials.gov, identifier: NCT03579082.
Impact of the COVID-19 Pandemic Lockdown on Routine Childhood Immunization: A Saudi Nationwide Cross-Sectional Study
Authors: Baghdadi Leena R. , Younis Afnan , Al Suwaidan Hessah I. , Hassounah Marwah M. , Al Khalifah Reem 
Published: June 2021

Background: Routine childhood immunization is the most cost-effective method to prevent infection and decrease childhood morbidity and mortality. The COVID-19 pandemic has affected access to health care in Saudi Arabia, including mandatory vaccinations for young children. We aimed to assess the prevalence of intentionally delayed vaccinations in children aged ≤ 2 years during the COVID-19 pandemic curfew in Saudi Arabia, its relation to the caregivers' fear of infection, and identifying factors affecting the caregivers' decision.Methods: We conducted a cross-sectional study using a self-administered survey that targeted primary caregivers of children aged ≤ 2 years residing in Saudi Arabia during the COVID-19 pandemic curfew (March 4–July 6, 2020).Results: We received responses from 577 caregivers, of whom 90.8% were mothers. The prevalence of intentional vaccination delay was 37%. Upon adjusting the potential confounders, the odds of delaying scheduled childhood vaccination because of COVID-19 pandemic fears were greater among caregivers with higher levels of fear (OR 1.10, 95% CI 1.02–1.11). Common reasons for delaying vaccinations were COVID-19 infection and prevention of exposure to COVID-19 cases.Conclusion: Intentional vaccination delay leaves young children vulnerable to preventable infectious diseases. Identifying these children and offering catch-up vaccinations reduces this risk. Campaigns to increase awareness about the dangers of delaying vaccine-preventable diseases must be promoted to caregivers in addition to the promotion of home vaccination services. In preparation for future pandemics, we recommend countries consider interventions to control the level of fear and anxiety provoked by the pandemics and media, and interventions for improved access to vaccinations.
Chinese Medicine Combined With EGFR-TKIs Prolongs Progression-Free Survival and Overall Survival of Non-small Cell Lung Cancer (NSCLC) Patients Harboring EGFR Mutations, Compared With the Use of TKIs Alone
Authors: Wang Yujia , Wu Guoyu , Li Ru , Luo Yingzhe , Huang Xingmei , He Lifang , Zhong Huihui , Xiong Shaoquan 
Published: June 2021

Objective: To explore the efficacy comparison between epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKIs) combined with traditional Chinese medicine (TCM) and single EGFR-TKIs for advanced non-small cell lung cancer (NSCLC).Methods: A total of 91 NSCLC patients with EGFR mutation were divided into an experimental group and a control group (in a ratio of 2:1) to receive TCM and EGFR-TKIs (61 cases) or single EGFR-TKIs (30 cases). Patients in the control group took EGFR-TKIs and those in the experimental group took EGFR-TKIs plus TCM. We analyzed the progression-free survival (PFS), overall survival (OS), disease control rate (DCR), and treatment-related adverse events of two groups.Results: The mPFS of the experimental group and the control group was 12.3 and 8.9 months (P = 0.02), respectively, and the mOS of the experimental group and the control group was 28.2 and 24.2 months (P = 0.02), respectively. Subgroup analysis showed that for the patients with exon 19 deletion mutation (19DEL), mPFS between experimental group and control group was 12.7 and 10.1 months, respectively (P = 0.12). For exon 21 deletion mutation (L858R), the PFS of two groups was 10.8 vs. 8.2 months, respectively (P = 0.03). The subgroup analysis also showed that, for the patients with exon 19 deletion mutation, mOS between the experimental group and the control group was 30.3 and 28.7 months, respectively (P = 0.19). For exon 21 deletion mutation, the mOS of two groups was 25.5 vs. 21.3 months, respectively (P = 0.01). The DCR of the experimental group and the control group was 93.3% and 80.1%, respectively (P = 0.77). Grade 3–4 treatment-related adverse events were less common with the experimental group (11.48%) than the control group (26.67%).Conclusion: For NSCLC patients with EGFR mutation, EGFR-TKIs combined with TCM had a certain effect to prolong mPFS and mOS, compared with the use of EGFR-TKIs alone, especially for the patients with L858R. This conclusion has a significant effect on improving the survival of NSCLC patients after EGFR-TKIs resistance. It deserves further study.
Does Parental Investment Shape Adult Children’s Fertility Intentions? Findings From a German Family Panel
Authors: Tanskanen Antti O. , Danielsbacka Mirkka 
Published: June 2021

Parents can play an important role in the childbearing plans of adult children. However, studies testing whether changes in parental investment are associated with subsequent changes in fertility intentions over time are lacking. We investigated whether parental investment, measured as contact frequency, emotional closeness, financial support, and childcare, is associated with adult children’s intentions to have a first and a second, or subsequent, child within the next 2 years. These associations were studied in four different parent-adult child dyads based on the sex of parents and adult children (i.e, mother-daughter, mother-son, father-daughter, father-son). The participants are from the German Family Panel, which is a longitudinal survey of younger and middle-aged adults with eight follow-up waves. We exploited within-person (or fixed-effect) regression models, which concentrated an individual’s variation over time (i.e., whether changes in parental investment frequencies are associated with subsequent changes in adult children’s fertility intentions). It was detected that increased emotional closeness between fathers and daughters was associated with increased adult daughter’s intentions to have a first child but father-daughter contact decreased daughter’s intentions to have another child, and maternal financial support decreased son’s intentions to have a first child. Overall, statistically nonsignificant associations outweighed significant ones. Although it is often assumed that parental investment is an important factor influencing the childbearing decisions of adult children, the present findings indicate that parental investment may not increase adult children’s intentions to have a/another child in Germany.
Analysis of Millennial Purchase Intention Using Modified UTAUT2 in Yogyakarta City
Authors: Hutami Lusia Tria Hatmanti 
Published: June 2021

The purpose of this study was to analyse the effect of hedonic motivation and online purchasing habits on online purchase intentions and the effect of habitual mediation on hedonic motivation and online purchase intentions by Millennial. The research method used the AMOS path analysis to 400 students at the Universitas Sarjanawiyata Tamansiswa, Yogyakarta. The results showed that all hypotheses were accepted except hedonic motivation towards online purchase intentions, while habitual mediation of hedonic motivation and online purchase intentions was accepted, thus strengthening this mediation relationship. Thus, it can be concluded that Millennial like the online shopping experience because it is considered fun and amusing and can lead to habitual behaviour. The implication for online purchasing application managers should not only prioritize short-term (momentary) relationships but prioritize long-term relationships therefore consumers become accustomed to using the application. The author's recommendation for managers is to always be creative and innovative, such as creating an attractive and profitable membership program. This research is limited to the number and distribution area of the sample and does not specifically refer to a particular application. Suggestions for further research include the impact of social relationships and the facilitating conditions applied to online purchase intentions.
INTERVENÇÃO FISIOTERAPÊUTICA NA PROMOÇÃO E PREVENÇÃO DE DISTÚRBIOS DA COLUNA VERTEBRAL EM IDOSOS
Authors: Doliny Andre Eduardo Falcoski , Miranda Flávia Cristina , Perez Jéssica , Dias Luiza Grassmann , Macedo Ana Carolina  Brandt de , Szkudlarek Ariani , Gallo Rubneide , Zotz Talita Gnoato 
Published: June 2021

Este relato de experiência tem como objetivo expor a vivência de alunos da Universidade Federal do Paraná - UFPR, na disciplina de Habilidades Fisioterapêuticas, os quais montaram um grupo de promoção e prevenção a doenças de coluna vertebral em idosos. Foram realizados 13 encontros com média de 3 horas cada em um espaço cedido, localizado no bairro Alto no município de Curitiba – PR. No local, foram oferecidas palestras educacionais com temas sobre a prevenção de distúrbios musculoesqueléticos e da coluna vertebral; informações sobre alimentação; respiração; depressão; risco de quedas; e a importância de exercícios físicos. Associadas aos temas, eram planejadas atividades lúdicas que permitiram um melhor aprofundamento e consolidação do assunto abordado. Os participantes eram estimulados a interagirem com suas histórias e experiências. Observa-se que as atividades do grupo obtiveram resultados significantes tanto para os alunos quanto para os idosos. Esses puderam estabelecer um vínculo firmado pelos encontros semanais. Além dos benefícios da atividade física inserida regularmente na vida dos idosos, o grupo proporcionou a interação social entre as diversas pessoas que frequentaram os encontros. Foi visto, com as situações vivenciadas na disciplina, que existe uma necessidade de viabilizar programas com foco em educação em saúde que proporcionem à população um envelhecimento mais saudável e menos oneroso. Por fim, concluímos que a atuação do fisioterapeuta na saúde primária é de grande importância para a população idosa. Esta prática minimiza possíveis acometimentos causados pela senescência. Considera-se que o objetivo do grupo foi alcançado visto o crescimento do número de participantes a cada novo encontro e por meio dos relatos sobre a melhora da qualidade de vida desses.
Faktor-faktor yang Mempengaruhi Publikasi Informasi Keuangan pada Website Resmi Pemerintah Daerah se-Jawa Tengah
Authors: Anggara Yunita Eva 
Published: June 2021

This study aims to find out which factors have strong impact to the financial report publications on local government websites, due to the requirements of Good Government Governance, among others the principle of transparency and accountability. District/city governments in Central Java were selected as samples by consideration of the achievements and awards achieved related to transparency, accountability, and compliance. The variables used in this study were political competition, tenure, BPK audit options, total assets, leverage, and direct expenditure. Using Stata probit regression analysis tool, the results showed that the local governments in Central Java were in the increase of transparency and accountability stage, where this showed the success of the regional autonomy mission. There were upward trend of audit opinions and financial report publications on local government websites. All variables insufficiently affected internet publication of financial report The political map did not become disincentive for local heads in order to increase the transparency of financial reporting
Cambios tecnológicos en la educación, un tabú en la formación académica, pero una verdad para el estudiante y el profesor
Authors: Osuna Zabaleta Jesús María 
Published: June 2021

El presente artículo precisa la importancia de la tecnología en los entornos de formación académica, reflexiona sobre la evolución tecnológica y los recursos de las nuevas tecnologías en las aulas de clase, en los planes de estudio, y en las asignaturas de los estudiantes. La huella que está dejando la tecnología educativa en la educación y el cómo está impactando al aprendizaje en los diferentes espacios de conocimiento, en donde se imparte educación. En Colombia, y en cada uno de los rincones con los diferentes contextos; la huella que está dejando en cada espacio de formación, los hogares y lugares en donde la revolución tecnológica ha entrado, en donde los cuadernos, los libros y el lápiz están siendo reemplazados por los avances tecnológicos. Esta reflexión, en este artículo nos trasladara al pasado en los inicios de la educación, la tecnología y la comunicación hasta la actualidad.
Inteligencia artificial como recursos educativos abiertos
Authors: Ochoa valle Melanie , Espinoza Benavidez Patricia Noemi , Vargas Pérez Catalina Vitelia , Vargas Pérez Renan Alexander 
Published: June 2021

Entendemos por inteligencia la capacidad para comprender y/o solucionar problemas, o como sinónimo de conocimiento. Una cualidad que no es exclusiva del ser humano pese a que habitualmente se considera que somos la especie que más y mejor puede desarrollarla… o así ha sido hasta la irrupción de lo que conocemos, muchas veces a partir de prejuicios e información de relativa credibilidad, como Inteligencia Artificial (IA). Término que parte de una definición muy diferente a la que se le atribuye a la inteligencia orgánica y que, hace referencia a una disciplina científica dedicada a la creación de programas informáticos que son capaces de ejecutar operaciones, como el aprendizaje o el razonamiento lógico, con un grado de complejidad comparable al de la mente humana. Su aplicación en diferentes aspectos de nuestras vidas ha venido acompañada, desde sus primeras aplicaciones teóricas más o menos oficiales en la década de los 50 del siglo pasado, por un cierto recelo hacia las posibilidades de la IA como sustitutivo de la inteligencia humana. Lo que se ha visto acentuado en los últimos años después de que en el 2014 un ordenador consiguiese superar por primera vez el Test de Turing, utilizado para distinguir infaliblemente hasta ese momento la inteligencia humana de la artificial, pero que no han logrado el contener de la creciente utilización de la IA en diferentes áreas del conocimiento como, por ejemplo, la educación.
Optical Variability of ICRF3 Quasars in the Pan-STARRS 3Pi Survey with Functional Principal Component Analysis
Authors: Berghea C. T. , Makarov V. V. , Quigley K. , Goldman B. 
Published: June 2021

Abstract
We make use of individual (epoch) detection data from the Pan-STARRS “3π” survey for 2863 optical ICRF3 counterparts in the five wavelength bands g, r, i, z, and y, published as part of the Data Release 2. A dedicated method based on the Functional Principal Component Analysis is developed for these sparse and irregularly sampled data. With certain regularization and normalization constraints, it allows us to obtain uniform and compatible estimates of the variability amplitudes and average magnitudes between the passbands and objects. We find that the starting assumption of affinity of the light curves for a given object at different wavelengths is violated for several percent of the sample. The distributions of rms variability amplitudes are strongly skewed toward small values, peaking at ∼0.1 mag with tails stretching to 2 mag. Statistically, the lowest variability is found for the r band and the largest for the reddest y band. A small “brighter-redder” effect is present, with amplitudes in y greater than amplitudes in g in 57% of the sample. The variability versus redshift dependence shows a strong decline with z toward redshift 3, which we interpret as the time dilation of the dominant time frequencies. The colors of radio-loud ICRF3 quasars are correlated with redshift in a complicated, wavy pattern governed by the emergence of brightest emission lines within the five passbands.
Déconstruire les idées reçues sur les start-up, la nouvelle responsabilité dévolue aux acteurs de l’accompagnement entrepreneurial
Authors: Houy Thomas , Bazenet Flavien 
Published: June 2021

L’intense médiatisation autour des start-up du numérique a conduit à populariser, auprès du grand public, un certain nombre d’idées reçues sur l’entrepreneuriat. Le présent article établit que les primo-entrepreneurs, en raison de leur manque d’expérience dans la conduite d’un projet de création d’entreprise, adhérent à ces lieux communs. Les résultats de cette recherche confèrent donc aux acteurs de l’accompagnement entrepreneurial une nouvelle prérogative : déconstruire, auprès des jeunes porteurs de projets, l’ensemble de ces clichés et de ces représentations fallacieuses du monde des start-up véhiculés par la presse. L’article se fonde sur des données d’enquêtes réalisées auprès de 90 278 personnes ayant signalé leur intérêt pour la création d’entreprise entre 2007 et 2018 1 . Nous isolons les réponses données par les porteurs de projets numériques et les comparons à celles des autres répondants. L’examen des croyances de ce large panel permet de montrer que les primo-entrepreneurs du numérique pensent pouvoir accéder à des rémunérations élevées, envisagent le succès avec une probabilité forte, se lancent dans l’entrepreneuriat en étant relativement peu préparés et anticipent une amélioration de leur employabilité en cas d’échec de leur entreprise.
Le 1 er Mooc français : les coulisses d’une aventure intrapreneuriale
Authors: Verzat Caroline , Bachelet Rémi 
Published: June 2021

Rémi Bachelet, maître de conférences à l’École Centrale de Lille, travaille particulièrement sur l’innovation pédagogique et notamment les cours en ligne. Il a lancé le Mooc 1 « Gestion de Projet » (GdP), 1 er Mooc français en termes de nombre de participants (256 562 depuis 2013 2 ). Contrairement à la plupart des Moocs, il n’a pas nécessité de lourds investissements et fonctionne avec un business model frugal. Quelles sont les clés pédagogiques, organisationnelles et économiques de l’aventure ? Cet entretien explique le fonctionnement atypique du Mooc GdP en racontant l’histoire de sa mise en place et met en perspective les enseignements de son concepteur après 7 ans de fonctionnement.
Pratiquer le peer learning pour repenser la formation à l’ère du numérique
Authors: Liu Tiphaine , Patillon Romain 
Published: June 2021

Le peer learning ou l’apprentissage entre pairs (AEP) rencontre un succès croissant dans les milieux des nouvelles technologies profitant des possibilités offertes par les nouveaux outils numériques. Quels sont les enjeux et les conditions d’application d’une telle démarche ? À travers la présentation de trois cas où l’AEP est mis en pratique, une école et deux start-up qui en ont fait leur cœur de métier, se dessinent les contours d’un nouveau paradigme d’apprentissage à l’ère du numérique effaçant les frontières entre sachant et apprenant, entre savoirs académiques et savoir situés, entre nécessité de présence et utilisation des outils numériques à distance. Une démarche riche d’enseignements pour l’accompagnement des entrepreneurs.