bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients
Authors: Deng Xia , Cai Zhensheng , Li Yanyan , Wu Xunan , Zhao Li , Li Haoxiang , Chen Ke , Zhang Panpan , Wang Chenxi , Zhao Zhicong , Yang Ling , Yuan Guoyue 
Published: November 2021

ObjectiveEctodysplasin A (EDA), a newly discovered hepatokine, has recently been considered to be closely related to glycolipid metabolism disorders, but the pathophysiological effects of EDA are still poorly understood. This study was the first time to determine the level of serum EDA in newly diagnosed type 2 diabetes mellitus (T2DM) patients, and to explore the relationships between serum EDA levels and various metabolic indexes.MethodsA total of 184 subjects were enrolled in the study, including 92 subjects with newly diagnosed T2DM and 92 subjects with age- and sex-matched normal glucose tolerance (NGT). Serum EDA levels were determined using enzyme-linked immunosorbent assay (ELISA). Oral glucose tolerance test, glycosylated hemoglobin c (HbA1c), and insulin were also measured.ResultsSerum EDA levels were significantly increased in the T2DM group than in the NGT group (359.91 ± 117.99 vs. 265.82 ± 86.51 pg/ml, p &lt; 0.001). Serum EDA levels were positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), HbA1c, 2-hour postprandial plasma glucose (2hPG), fasting plasma insulin (FIns), fasting C peptide (FCP), triglyceride (TG), HOMA-IR, and negatively correlated with high-density lipoprotein cholesterol (HDL-c) and HOMA-β (p &lt; 0.05). Multiple stepwise regression analysis demonstrated that 2hPG and FIns were independent influencing factors of serum EDA level (p &lt; 0.05). Logistic regression analysis showed that serum EDA level was significantly independently correlated with T2DM (p &lt; 0.05).ConclusionsSerum EDA levels are significantly higher in T2DM patients, suggesting that EDA may play a role in the occurrence and development of T2DM.
Keabsahan Identitas dalam Administrasi Kependudukan
Authors: Afdhal Afdhal 
Published: November 2021

Abstract This study aims to identify and explain the purpose of sticking client fingerprint To identify and explain the legal status of fingerprints on Electronic citizen Card (E-KTP) with sticking client fingerprint on the public administration.The research was conducted as an Empirical legal research with socio-legal research approach. The data were collected using structured interview techniques. Data were analyzed qualitatively.The results of the study explained that the purpose of sticking clien fingerprint has not completely realized the legal assurance the correct fingerprint, consequently administration can not use the fingerprint data effectively. Fingerprints used by notaries and fingerprints appear on electronic citizen card have a legal status as authentic evidence of the a citizen’s identity. Implementation sticking fingerprints do Civil Registry Office has a mechanism and standard operating procedure from the stage of registration, data entry and verification of data so that the results can be used as the information and valid. But sticking obligation fingerprint notaries do is rely on the interpretation of each requires a considerable time in the match the data client Purpose, Fingerprints, Public Administration
PERAN PENYIDIK KEPOLISIAN TERHADAP ANAK YANG BERKONFLIK DENGAN HUKUM DALAM PERSPEKTIF RESTORATIVE JUSTICE
Authors: Muhdi Imam 
Published: November 2021

Abstract Children are the hope of the nation. But reality shows that children are still involved in various forms of crime. Meanwhile, the police as law enforcers are expected to handle criminal cases involving children as a perpetrator with a different approach, namely the approach of restroative justice. This is what becomes the rationale for research with two objectives: (1). The role of police investigators on children in conflict with the law with a restroative approachjustice; (2). Forced efforts that can be carried out by police investigators on children in conflict with the law. This research is a normative study with two approaches, namelylegislation approach and conceptual approach. Based on this approach, the overall results of the study were analyzed argumentatively qualitatively. The results of the study indicate that police investigators have a very important roleimportant in handling crime cases involving children by exposing the child to putting forward the approach of restroative justice. The results of subsequent research, that forced efforts by police investigators againstchildren who are in conflict with the law in the approach of restroative justice, which should prioritize human values by integrating the role of the community, given the development of the child's soul. The recommendation of researchers is that police investigators handling child crimes should be provided with special skills that prioritize the approachrestroative justice. Keywords: Children, Police Investigators, and Restorative Justice
KEDUDUKAN SIGHAT TAQLIQ TALAQ DALAM HUKUM ISLAM
Authors: Muhja Zainal Abidin 
Published: November 2021

Weddings are performed by bond of trust , means that men and women who were married in the territory of the Republic of Indonesia shall have the religion together . The principle of the law of marriage is absolute means to not have a period of time dalaluarsa . Marriage must also be registered at the Office of Religious Affairs and registered atNote Civil . Marriage is an agreement between a man and a woman in the scope of family law . Marriage is a worship that will continue to take place up in heaven . By because it's every couple must keep the rope marriage that is not interrupted and canceled . Inamong those who cancel the marriage are divorce. Divorces according to Language is decided bond . As for the term fiqhi is decided bond of marriage with the pronouncement of talaq or that convey the same to the pronouncement of divorce . This study discusses "the effect of the Sighat Tak'lik agreement on the marriage bond in Sharia and its impact on divorce in religious courts in Tarakan City "The research is aimed to know the result of treaty sighat Tak'lik and its impact on the divorce that happened in court Religion Tarakan City and knowing Forms agreement sighat Tak'lik who cancels wedding in sharia . The type of research that is used is the study of law Juridical Normative among others case approach, conceptual approach and statute approach. Case approach is the approach by way of doing research on the case - a case that relates to the issues that face . Keywords: Sighat Taqliq , Talaq, Marriage , Marriage , Shariah
BENTUK KETERBUKAAN RAHASIA MEDIS DALAM SITUASI PANDEMI VIRUS COVID 19 DI INDONESIA
Authors: Afdhal Afdhal , Irvansyah Irvansyah 
Published: November 2021

The right to confidentiality or privacy is something unique between a patient's relationship with a doctor because it is based on trust. This patient-doctor relationship is unique because the patient believes in the doctor's ability and the patient believes the doctor will keep the patient's secret. The influence of the covid 19 outbreak has made people nervous and afraid because the virus is very easy to spread and spreads globally. The community asks to open data related to the secrets of Covid 19 patients, both in the form of names, addresses, symptoms, diagnosis, and interactions that have been made. Patient data which is classified as a basic right to privacy is an important component in breaking the chain of the spread of Covid 19 because the government has implemented large-scale social restrictions in certain areas to maintain social interactions so that the community can avoid exposure to this virus. This needs to be studied in depth regarding the Forms of Disclosure of Medical Secrets in the PANDEMIC Covid 19 Situation in Indonesia.This type of research is normative juridical research or what is known as doctrinal research. Normative juridical research is research that looks at problems through the aims and objectives to be achieved using surgical tools in the form of statutory regulations and regulations in a formal hierarchy of regulations as well as theoretical studies of updated and modern literature.Covid 19 Patient Information is data stored in medical records that can be provided based on patient consent or the law. But in Article 57 paragraph (2) of Health Law, the right to confidentiality is excluded, one of which is for the benefit of society. The doctor's obligation to keep information related to the patient's medical condition is an obligation as described in the Republic of Indonesia Minister of Health Regulation Number 269 / MENKES / PER / III / 2008 concerning Medical Records but in the event of an outbreak or pandemic covid 19, the disclosure of secrets is carried out with the covid procedure, namely by evaluating the interaction of patients who have been in SWAB Positive and carry out self-isolation for COVID 19 patients without symptoms and medical isolation for patients with symptoms. Keyword: Information, Covid 19, Hukum, Privacy
Redesign Woodeco Stool
Authors: Marpaung Jhon Viter , Fauzi Muhammad , Prastyani Desy 
Published: November 2021

The concept applied to the design of stool furniture this time carries the
theme that will be used, namely Scandinavian. A product that will be
designed through trend analysis, through the uniqueness of the design
owned. The uniqueness is presented through a combination of foreign
and traditional cultures, being a style inspiration for designers and
becoming the first choice product for the community in its needs.
Qualitative methods with an event approach that is carried out make a
direct source for designers to conduct a renewable data research so as to gain knowledge about the style and concept of a broader design to be applied to a design design this time. Market segmentation or User is
intended is an urban society that has a standardization of modern living,
as well as the characteristics of users who have uniqueness in a work
such as creative workers oriented in the field of art or creative. This
product is intended for families who have a modern lifestyle, with the
implementation of modern product styles making this design has a
concept of styling organic design that is combined with the application of batak toba motifs as the preservation of cultural products to preserve
cultural knowledge to make their own scandinavian-style products
The Mass Distribution of Neutron Stars in Gravitational-wave Binaries
Authors: Landry Philippe , Read Jocelyn S. 
Published: November 2021

Abstract
The discovery of two neutron star–black hole coalescences by LIGO and Virgo brings the total number of likely neutron stars observed in gravitational waves to six. We perform the first inference of the mass distribution of this extragalactic population of neutron stars. In contrast to the bimodal Galactic population detected primarily as radio pulsars, the masses of neutron stars in gravitational-wave binaries are thus far consistent with a uniform distribution, with a greater prevalence of high-mass neutron stars. The maximum mass in the gravitational-wave population agrees with that inferred from the neutron stars in our Galaxy and with expectations from dense matter.
Roles of Midwives and Indonesian Midwives Association in Reducing Risk Factors for Stunting in Indonesia
Authors: Sumiaty Sumiaty , Ali Muhammad Nur , Muhamad Hasan , Hafid Fahmi 
Published: November 2021

Background: Stunting is caused by multi-dimensional factors and the most decisive intervention should be carried out in the first 1,000 days of life. Poor parenting practices, lack of knowledge about health and nutrition before and during pregnancy are some of the contributing factors and 60% of children aged 0-6 months do not receive exclusive breastfeeding.
Aim: To assess the role of midwives and the Indonesian Midwives Association Professional Organization in reducing the risk of stunting in Indonesia.
Method: This type of descriptive research uses an exploratory study approach by assessing the role of midwives and the professional organization of the Indonesian Midwives Association (IBI) in reducing the risk of stunting in Central Sulawesi. The data of 288 midwives were collected using google form from 22 July 2020 to 22 August 2020. Data were analyzed by SPSS.
Result: In general, midwives have provided maternal and child health books to pregnant women, recorded complete maternal and child health records, conducted antenatal care for pregnant women, provided nutritional food counseling for pregnant women, gave Fe 90 tablets to pregnant women, provided calcium tablets to pregnant women, conducting classes for pregnant women, delaying umbilical cord cutting (>30 minutes), providing vitamin A to postpartum mothers, conducting exclusive breastfeeding counseling, providing family planning services, providing IYCF counseling. However, for the activities of Implementing a special stunting prevention program, implementing postnatal care and initiating early breastfeeding still need improvement.
Conclusion: The role of midwives in efforts to prevent stunting in Indonesia with midwives have provided maternal and child health books to pregnant women. Delaying umbilical cord cutting to 30 minutes, giving vitamin A to postpartum mothers, breastfeeding counseling, providing family planning services, providing IYCF counseling
La réforme de l’université en France et son impact sur le management des établissements : une transformation en accordéon
Authors: Bollecker Marc 
Published: November 2021

L’objet de cet article est d’analyser si les réformes engagées en France pour moderniser les universités publiques ont conduit au déploiement de pratiques basées sur du New Public Management . L’étude est fondée sur une analyse détaillée des 7 dimensions du New Public Management telles que définies par Hood (1991). Les résultats dévoilent une évolution en accordéon : si certaines pratiques tendent vers le déploiement de pratiques relevant du New Public Management , les universités conservent des principes d’une organisation centrée sur l’État et sur la collégialité.
Establishment and evaluation of a Sprague-Dawley rat model of intramedullary spinal cord glioma
Authors: Liu Dongkang , Yi Guo , Wang James Jin , Wang Guihuai 
Published: November 2021

Background and Aim:
Intramedullary spinal cord glioma has no evident boundary with normal spinal cord tissue. The rate of successful surgical resection of intramedullary spinal cord glioma is low. Well-established animal models for intramedullary spinal cord glioma can help promote translation from related basic therapy research to clinical applications. In this study, we established a rat model of intramedullary spinal cord glioma.

Materials and Methods:
A total of 23 male Sprague-Dawley (SD) rats were randomized into blank control (n = 3) and experimental (n = 20) groups. The blank control group received intramedullary injection of Dulbecco's modified Eagle medium (DMEM) and the experimental group was injected with DMEM containing C6 glioma cells. The neurological states of these rats were evaluated using the Basso, Beattie, and Bresnahan scale (BBB). Tumor sizes were measured by magnetic resonance imaging. The histopathological analysis was performed to observe the growth of infiltrating tumors. All procedures involving animals were approved by the Ethics Committee of the Laboratory Animal Facility Biomedical Analysis Center, Tsinghua University (Beijing, China; approval No. 17-WGH1).

Results:
On postoperative 7 days, the experimental group presented with a significant progressive decrease in motor function (mean BBB score 15.00 ± 1.20) compared with the blank control group (20.67 ± 0.47, P < 0.01). All rats in the experimental group showed exponential tumor growth and had an average survival of up to 5 weeks after tumor cell implantation. The tumor sizes were 3.18 ± 0.21 mm3, 68.55 ± 3.38 mm3, and 345.28 ± 22.57 mm3 on postoperative 7, 14, and 28 days. The histopathological analysis illustrated that the growth of infiltrating tumors followed the longitudinal axis of the spinal cord.

Conclusions:
Thus, we have established a SD rat model of intramedullary spinal cord glioma, and we found that our findings are reproducible and homogeneous. These positive results provide solid bases for further studies of intramedullary spinal cord glioma.
Undisclosed payments by pharmaceutical manufacturers to authors of inflammatory bowel disease guidelines in the United States
Authors: Al Sulais Eman , Alsahafi Majid , AlAmeel Turki 
Published: November 2021

Background:
Payments from pharmaceutical drug manufacturers to authors of clinical practice guidelines (CPGs) may have an impact on their recommendations. In this study, we aimed to evaluate the accuracy of financial conflict of interest (FCOI) declarations among authors of Inflammatory Bowel Disease (IBD) guidelines.

Methods:
We collected data on industry payments to authors of IBD guidelines published by the American Gastroenterology Association (AGA), American College of Gastroenterology (ACG) and American Society of Gastrointestinal Endoscopy (ASGE). We reported the accuracy of the authors' declarations by comparing their statements in the FCOI section of the guidelines with the data reported on the Centers for Medicare and Medicaid Services website (CMS-OP). We also investigated the adherence of IBD guidelines to the National Academy of Medicine (NAM) criteria for trustworthy guidelines.

Results:
A total of eight clinical practice guidelines and 35 individual authors were included. Four authors had no profile identified at CMS-OP. The total payment to all included authors was $10,575,843.06, with a mean payment of $314,242.38 per author. A total of 28/35 authors (80%) received payment from pharmaceutical companies, 23/35 (65.7%) received $10,000 or more, 15/35 (42.8%) received $100,000 or more and 3/35 (8.57%) received $1,000,000 or more. Total discrepancies identified while comparing the authors' declaration of their FCOI and CMS-OP were 28: ACG had 12/14 (85.7%), AGA had 7/12 (53.8%) and ASGE had 9/10 (90%) discrepancies. None of the guidelines met all NAM criteria and 4/8 (50%) guidelines met none.

Conclusions:
Discrepancies exist between authors' declarations in the FOCI section and data on CMS-OP. Poor compliance with the NAM criteria was prevalent among authors of IBD guidelines. More transparency in reporting and monitoring is needed.
Analysis of Criminal Law Sanctions' Application Against Statutory Rape from the Positive Law Perspective on Ambon Island and Lease Islands
Authors: Rahawarin Fauzia , Nursalam Nursalam 
Published: November 2021

The purpose of this study was to analyze the application of criminal law sanctions against statutory rape in Indonesia. The analysis employed a positive law perspective and an empirical legal approach. The research data consisted of verbal utterances and observation results collected from Criminal Investigators at the Ambon Island and Lease Islands’ police stations. Data analysis was carried out through (1) data reduction, (2) data display, and (3) conclusion. The results of this study indicate that criminal sanctions against statutory rape in Indonesia are applied through the process of investigation, visum et repertum, prosecution and summons of suspects and witnesses, statements of criminal penalties for the perpetrators, and prevention of sexual immorality and rape. The criminal sanctions are based on “Law Number 35 of 2014 about Amendments to Law Number 23 of 2002 concerning Child Protection Articles 76D and 81.

Keywords: criminal, intercourse, positive law
The Intercultural Communication Competence of International Students in Indonesia: A Case Study Approach of Darmasiswa Program
Authors: Larasati Ayu , Mayagita Avradya 
Published: November 2021

Currently, there are many international students come to Indonesia to learn the language and culture. However, it is undeniable that they experienced a very diverse culture shock when they arrived in Indonesia. There are many differences that they experience ranging from weather, food, different ways of eating, time and delay problems to different type of toilet. This study aims to answer the questions on how they adapt to the new culture, and how to become competent in intercultural communication. This is a qualitative research with a case study approach. Data collection was obtained by semi-structured interviews with 8 international students who are studying language and culture in Indonesia. The results showed that intercultural communication competence can be possessed by international student if they have a motivation to learn that can make them more easily to adapt with new cultures and environment.
Một số yếu tố liên quan đến viêm phổi sơ sinh nặng có nhiễm virus hợp bào hô hấp tại Trung tâm Sơ sinh Bệnh viện Nhi Trung ương
Authors: Trang Nguyễn Thị , Dung Khu Thị Khánh 
Published: November 2021

Mục tiêu: Xác định một số yếu tố liên quan đến viêm phổi nặng do nhiễm virus hợp bào hô hấp (RSV) ở trẻ sơ sinh.
Phương pháp: Nghiên cứu mô tả cắt ngang trên 157 trẻ sơ sinh viêm phổi do RSV tại Bệnh viện Nhi Trung ương.
Kết quả: Các yếu tố liên quan tới tình trạng viêm phổi RSV nặng bao gồm: Đẻ non (OR = 3,8; p<0,05); đồng nhiễm vi khuẩn (OR = 2,9; p<0,05); tăng bạch cầu đa nhân trung tính (37,2 ± 16,2 % so với 31,7 ± 15,4 %), tăng CRP (6,8 ± 12,1mg/L so với 2,4 ± 3,5 mg/L ở nhóm viêm phổi nhẹ); toan hô hấp còn bù với CO2 trong nhóm viêm phổi nặng trung bình là 51,98 ± 13,2.
Kết luận: Nghiên cứu cung cấp tỷ lệ viêm phổi sơ sinh nặng có nhiễm RSV ở trẻ sơ sinh và về các yếu tố liên quan đến viêm phổi nặng có nhiễm RSV ở trẻ sơ sinh gồm đẻ non, đồng nhiễm vi khuẩn, tăng bạch cầu đa nhân trung tính, tăng CRP.
Current Aspect of Bisphenol A Toxicology and Its Health Effects
Authors: Khamphaya Tanaporn , Pouyfung Phisit , Kuraeiad Saruda , Vattanasit Udomratana , Yimthiang Supabhorn 
Published: November 2021

Bisphenol A (BPA) is a synthetic and dangerous chemical that is released extensively into the environment. BPA is utilized to synthesize polycarbonate plastics for an assortment of basic items such as electronic gadgets, housewares and apparatuses, water pipes, food packaging and containers. Because of the widespread use of BPA products, people are easily exposed to BPA from using these products in their daily life, especially BPA-contaminated food. BPA intake is found in Oceania, Asia, Europe, and North America in both children and adults. Ingestion is a significant route of BPA exposure. The mechanisms of BPA toxicity involve oxidative stress production, genetic and epigenetic dysregulation, nuclear receptor dysfunction, insulin resistance, and adipose tissue inflammation. Exposure to BPA has many health effects, which include altered neurogenesis and reproductive toxicity. Recently, BPA has also been associated with non-communicable diseases, including cardiovascular disease, cancer, lipid disorder, and diabetes. Toxicological data could provide insights that might be useful for promoting awareness to BPA toxicity and preventing BPA-associated diseases. Herein, this review aims to summarize the current knowledge on the toxicological profiles and health effects of BPA, with emphasis on the mechanisms of its toxicity.
HIGHLIGHTS

Human exposure to BPA is a major public health concern owing to toxicity
Contaminated seafood and food containers are important sources of BPA exposure
BPA toxicity involves the endocrine, neuronal, cardiovascular, and reproductive systems
Mechanisms of BPA toxicity has been linked to nuclear receptor, genetic and epigenetic, oxidative stress, and brain receptors
Pregnant women and children are especially vulnerable to BPA exposure

GRAPHICAL ABSTRACT