bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired Peripheral Microvascular Function and Risk of Major Adverse Cardiovascular Events in Patients With Coronary Artery Disease
Authors: Young An , Garcia Mariana , Sullivan Samaah M. , Liu Chang , Moazzami Kasra , Ko Yi-An , Shah Amit J. , Kim Jeong Hwan , Pearce Brad , Uphoff Irina , Bremner J. Douglas , Raggi Paolo , Quyyumi Arshed , Vaccarino Viola 
Published: March 2021

Objective:
In patients with stable coronary artery disease (CAD), the risk of major adverse cardiovascular events (MACE) remains elevated despite treatment. The role of microvascular dysfunction on MACE beyond traditional risk indicators and inflammation is not well established. We examined whether peripheral microvascular dysfunction is associated with MACE in patients with CAD.

Approach and Results:
Microvascular function was measured with the Reactive Hyperemia Index (RHI) using digital peripheral arterial tonometry in 546 patients with CAD, who were followed 7 years for incident MACE. The primary end point included cardiovascular death or myocardial infarction; the secondary end point included cardiovascular death, myocardial infarction, or heart failure hospitalization. Hazard models for competing risk were used to estimate the association between RHI and MACE adjusting for age, sex, race, traditional risk factors, medications, and CAD severity. We also examined the association of baseline interleukin-6, C-reactive protein, monocyte chemoattractant protein-1, and matrix metallopeptidase-9 with RHI.

Mean age was 62±9 years. Mean RHI was 2.1±0.63. After adjustment, for each 1-SD decrease in RHI, there was a 40% increase in the primary end point (hazard ratio, 1.4 [95% CI, 1.1–1.9],
P
=0.01) and a similar increase in the secondary end point (HR, 1.3 [95% CI, 1.1–1.7],
P
=0.006). Inflammatory biomarker levels were associated with greater RHI impairment (
P
<0.05) but did not affect the relationship between RHI and MACE.

Conclusions:
Peripheral microvascular dysfunction is associated with increased risk of MACE in patients with stable CAD, implicating the role of microvascular disease in the pathogenesis of adverse outcomes in patients with CAD.
Universality of citation distributions: A new understanding
Authors: Golosovsky Michael 
Published: March 2021

AbstractUniversality of scaled citation distributions was claimed a decade ago but its theoretical justification has been lacking so far. Here, we study citation distributions for three disciplines—Physics, Economics, and Mathematics—and assess them using our explanatory model of citation dynamics. The model posits that the citation count of a paper is determined by its fitness: the attribute, which, for most papers, is set at the moment of publication. In addition, the papers’ citation count is related to the process by which the knowledge about this paper propagates in the scientific community. Our measurements indicate that the fitness distribution for different disciplines is nearly identical and can be approximated by the log-normal distribution, while the viral propagation process is discipline specific. The model explains which sets of citation distributions can be scaled and which cannot. In particular, we show that the near-universal shape of the citation distributions for different disciplines and for different citation years traces its origin to the nearly universal fitness distribution, while deviations from this shape are associated with the discipline-specific citation dynamics of papers.
Latent Compositional Representations Improve Systematic Generalization in Grounded Question Answering
Authors: Bogin Ben , Subramanian Sanjay , Gardner Matt , Berant Jonathan 
Published: March 2021

AbstractAnswering questions that involve multi-step reasoning requires decomposing them and using the answers of intermediate steps to reach the final answer. However, state-of-the-art models in grounded question answering often do not explicitly perform decomposition, leading to difficulties in generalization to out-of-distribution examples. In this work, we propose a model that computes a representation and denotation for all question spans in a bottom-up, compositional manner using a CKY-style parser. Our model induces latent trees, driven by end-to-end (the answer) supervision only. We show that this inductive bias towards tree structures dramatically improves systematic generalization to out-of- distribution examples, compared to strong baselines on an arithmetic expressions benchmark as well as on C losure, a dataset that focuses on systematic generalization for grounded question answering. On this challenging dataset, our model reaches an accuracy of 96.1%, significantly higher than prior models that almost perfectly solve the task on a random, in-distribution split.
An Epistemic Troika
Authors: Fine Gail 
Published: March 2021

Abstract
In a characteristically stimulating and important paper, ‘Episteme’, Myles Burnyeat discusses what he calls the epistemic troika, which consists of knowledge by acquaintance, knowledge that, and knowledge how. He argues that the troika ‘lacks universal validity’; he ‘suspects’ that it is the product of Anglophone philosophy in the 1950s-early 1970s. He also challenges the philosophical value of the troika. In my paper, I explore the troika, both in its own right and as a guide to Plato’s epistemology; I also assess Burnyeat’s views on these issues.
Drinking and Discourse in Plato
Authors: Anagnostou-Laoutides Eva , Payne Andrew 
Published: March 2021

Abstract
The article argues that in the Symposium, but also the Phaedrus and the Protagoras, Plato instructs us on the correct way of engaging in discourse by adducing examples from the activities of drinking and singing (/performing poetry). By presenting Socrates as grappling with the use of wine, rhetoric and poetry, almost failing at times, but always able to recollect himself and identify the faults in his methods (as well as of others), Plato recognizes the difficulties of the process, while acknowledging Socrates’ extraordinary intellect.
Plotinus on the Conception of Time (ennoia chronou): A Re-Examination of Enn. 3.7(45).12
Authors: Michalewski Alexandra 
Published: March 2021

Abstract
This paper aims to revisit a debated issue concerning the formation of the “conception of time” in Plotinus’ treatise On Eternity and Time. Over the last several years, studies have drawn attention to the fact that ennoia (“conception”) in Plotinus does not always refer to the existence of an innate notion in the soul, but that it can also refer to a conception that is formed empirically. However, it is unclear whether this holds true also for the conception of time. My claim is that, far from attributing an empirical origin to the formation of the ennoia of time, Plotinus is committed to distinguishing the ennoia of number, which measures times, from the ennoia of time in the proper sense. However, just as it is necessary to distinguish essential time from its manifestation, measured by the movements of the heavenly bodies, we must also distinguish the innate notion of essential number, which the soul naturally possesses in itself, from the notion of arithmetical number, obtained through the observation of discrete quantities. This paper thus proposes to read Enn. 3.7(45).12 in connection with the analyses developed in Enn. 6.6(34).4, which concern the ennoia of number.
The Many Voices of a Teacher without Teachers
Authors: Motta Anna 
Published: March 2021

Abstract
The aim of this paper is to show that an introductory step to the Neoplatonic exegesis of the dialogue was to redefine the figure of Socrates and Socratism, so as to offer aspiring Platonists a correct interpretation of Plato and of the Neoplatonic metaphysical system. In the final stages of a long tradition, Socrates became the teacher par excellence not only of Plato but of all Platonists. In particular, by focusing on the Prolegomena to Platonic philosophy I wish to highlight the fact that, when it comes to teaching, there is no Socrates but Plato’s teacher, a teacher whose many voices – universalised according to well-defined criteria – can also be attributed to Plato. If Plato came to be seen as polyphonic and always self-consistent, this is probably because it was possible to show that Socrates’ hallmark was his ability to remain consistent while expressing many different opinions in the dialogues.
L’“uno” e l’“intelletto” dell’anima umana: ricezioni neoplatoniche del Fedro di Platone
Authors: Neola Benedetto 
Published: March 2021

Abstract
Thanks to the exegesis, Iamblichus succeeds in forging a psycho-epistemological doctrine which can boast a remarkable degree of consistency, albeit not always without minor flaws. Notably, the exegesis of Plato’s Phaedrus plays a pivotal role in constructing this system, despite moving not from phrases of the dialogue, but simply from single words, like κυβερνήτης and ἡνίοχος. Iamblichus’ anathema against Plotinus’ psychology makes Socrates’ palinode the sacred text from which to elicit those formulae of orthodoxy bound to be devoutly recited by posterior Platonists, like Hermias of Alexandria. Indeed, in this text the divine Plato has revealed the essence of the triad νοερόν, νοητόν, κριτήριον, whose each element is susceptible of being dichotomized: νοερόν in νοῦς and ἕν, νοητόν in νοητόν and ἀκρότατα νοητά, κριτήριον in καθαρμός/φιλοσοφία and ἐνθουσιασμός/θεουργία. The result of this complex and fascinating move is an outstanding proof of philology and philosophy, psychology and epistemology hermeneutics and mysticism.
The Secularisation Thesis Recast: Christianity in Modern China and South Korea
Authors: Baar Jemima A.H. 
Published: March 2021

Abstract
Steve Bruce’s and Karel Dobbelaere’s secularisation theses – that industrialisation, urbanisation, societalisation, and rationalisation erode religion on macro-, meso- and micro-levels – can be challenged by reference to the growth and vitality of Christianity in China and South Korea. Christianity propelled economic growth and political change in South Korea at the end of the twentieth century, and has recognised potential in China. Religious institutions play critical roles in contemporary South Korean and Chinese communities. Although in an economically dynamic age permeated by scientific thinking, Christianity thrives in the private sphere in China. The plateauing of the growth rate of South Korean Christianity in recent decades coincides with widespread stability and prosperity in the country, which may have reduced the psychological and practical needs for religion. Thus, the Secularisation Thesis ought to be recast: social stability and prosperity better explain religious decline than industrialisation, urbanisation, societalisation, and rationalisation.
The Springtime Western Pacific Pattern: Its Formation and Maintenance Mechanisms and Climate Impacts
Authors: Zhuge Anran , Tan Benkui 
Published: March 2021

AbstractBased on daily data from the Japanese 55-year Reanalysis (JRA-55) covering the spring seasons from 1958 to 2018, this study examines the formation mechanisms and climate impacts of the springtime western Pacific (WP) pattern as subseasonal climate variability over North Pacific. Results suggest that the springtime WP pattern arises from a weak dipole-like disturbance over North Pacific and disturbances over East Asia. The energetic analysis suggests that the baroclinic energy conversion acts as an important energy source to balance the available potential energy loss caused by transient eddies and diabatic heating and acts as a kinetic energy (KE) source for the WP pattern. For the feedback forcing by total transient eddies, it acts as a major KE source for the WP pattern before day 0 and acts as a strong KE sink after day 0. It turns out that the barotropic energy conversion makes only weak KE contribution to the WP pattern. Once the WP pattern forms, East Asia and North America experience strong surface air temperature anomalies of opposite signs, while strong sea surface temperature anomalies are found to occur over midlatitude and tropical North Pacific at the same time. Concurrently, the Pacific jet and the storm track shift northward or southward around their climatological position. In addition, a dipole-like shallow convective anomaly appears over midlatitude North Pacific, and a band of anomalous deep convection tends to occur in the tropics as the energy of the WP pattern propagates into the region.
Joint Boost to Super El Niño from the Indian and Atlantic Oceans
Authors: Wang Jia-Zhen , Wang Chunzai 
Published: March 2021

AbstractSuper El Niño has been a research focus since the first event occurred. On the basis of observations and models, we propose that a super El Niño emerges if El Niño is an early-onset type coincident with the distribution of an Atlantic Niña (AN) in summer and a positive Indian Ocean dipole (IOD) in autumn, conditions referred to as the Indo-Atlantic Booster (IAB). The underlying physical mechanisms refer to three-ocean interactions with seasonality. Early onset endows super El Niño with adequate strength in summer to excite wind-driven responses over the Indian and Atlantic Oceans, which further facilitate IAB formation by coupling with the seasonal cycle. In return, IAB alternately produces additional zonal winds U over the Pacific Ocean, augmenting super El Niño via the Bjerknes feedback. Adding AN and IOD indices into the regression model of U leads to a better performance than the single Niño-3.4 model, with a rise in the total explained variances by 10%–20% and a reduction in the misestimations of super El Niños by 50%. Extended analyses using Coupled Model Intercomparison Project models further confirm the sufficiency and necessity of early onset and IAB on super El Niño formation. Approximately 70% of super El Niños are early-onset types accompanied by IAB and 60% of early-onset El Niños with IAB finally grow into extreme events. These results highlight the super El Niño as an outcome of pantropical interactions, so including both the Indian and Atlantic Oceans and their teleconnections with the Pacific Ocean will greatly improve super El Niño prediction.
High inter- and intra-observer agreement for measuring tissue oxygenation of the plantar surface of the foot in healthy participants with the Hyperview®: A pilot study
Authors: van Schilt Kaz LJ , Hollander Evert-Jan F , Veen Oscar C , Koelemay Mark J , van Geloven Anna AW , Olthof Dominique C 
Published: March 2021

Objectives The Hyperview® is a novel camera that applies hyperspectral imaging to project local concentrations of oxyhaemoglobin (OXY), deoxyhaemoglobin (DEOXY) and O2-saturation (O2-SAT) in a map. In this pilot validation study, we assessed inter - and intra-observer agreement for measuring OXY, DEOXY and O2-SAT in healthy participants. Methods The plantar region of the right foot was assessed with the Hyperview® in 50 healthy participants. Two consecutive pictures were taken by the same observer, followed by two images by a second observer. Measurements were performed without and with standardization (a static device for both the foot and the Hyperview camera). Inter- and intra-observer agreements were expressed as Intraclass Correlation coefficients (ICC) with their 95% confidence interval (CI). A score <0.40 indicates poor agreement, 0.40–0.59 fair, 0.60–0.74 good and 0.75–1.00 excellent agreement. Bland and Altman plots were also generated. Results Without standardization, the ICC values between the observers for OXY, DEOXY and O2-SAT ranged from 0.70 to 0.83. The intra-observer agreement of both observers ranged from 0.36 to 0.83. With standardization, the ICC values between the observers ranged from 0.80 to 0.82 and intra-observer agreement varied from 0.75 to 0.92. Four Bland and Altman plots were generated of the measurements of OXY by observers 1 and 2. Conclusions When standardization is used, the Hyperview® camera is a reliable device with excellent intra- and inter-observer agreements for the assessment of OXY, DEOXY and O2-SAT. In future research, the inter- and intra-observer agreements of the camera should be investigated in patients with diabetes and/or peripheral arterial disease.
Molecular clues in the regulation of mini‐puberty involve neuronal DNA binding transcription factor NHLH2
Authors: Hadziselimovic Faruk , Verkauskas Gilvydas , Stadler Michael B. 
Published: March 2021

AbstractGonadotropin releasing hormone agonist (GnRHa) treatment following surgery to correct cryptorchidism restores mini-puberty via endocrinological and transcriptional effects and prevents adult infertility in most cases. Several genes are important for central hypogonadotropic hypogonadism in mammals, including many that are transcribed in both the brain and testis. However, the expression of these genes in prepubertal gonads has not been studied systematically, and little is known about the effect of hormone therapy on their testicular and neuronal expression levels. In this review, we interpret histological sections, data on hormone levels, and RNA profiling data from adult normal testes compared to pre-pubertal low infertility risk (LIR) and high infertility risk (HIR) patients randomly treated with surgery in combination with GnRHa or only surgery. We organize 31 target genes relevant for idiopathic hypogonadotropic hypogonadism and cryptorchidism into five classes depending on their expression levels in HIR versus LIR samples and their response to GnRHa treatment. Nescient-helix-loop-helix 2 (NHLH2) was the only gene showing a decreased mRNA level in HIR patients and an increase after GnRHa treatment. This phenomenon may reflect a broader effect of hormone treatment on gene expression in both testicular and central nervous system tissues, which could explain why the hypothalamus-pituitary-testicular axis is permanently restored by the administration of GnRHa.
Cloning and expression analysis of GATA1 gene in Carassius auratus red var
Authors: Tian Yusu , Sun Yuandong , Ou Mi , Cui Xiaojuan , Zhou Dinggang , Che Wen’an 
Published: March 2021

AbstractBackgroundGATA1 is a key transcription factor in the GATA family, and promotes the differentiation and maturation of red blood cell, which is essential for normal hematopoiesis.ResultsOur results showed that the cDNA sequence ofGATA1 was 2730 bp long encoding 443 amino acids. qRT-PCR analysis demonstrated thatGATA1 had the highest expression in testis (T), followed by pituitary (P) and spleen (S).GATA1 gene expression inC. auratusred var. embryo from the neuroblast stage (N) to the embryo hatching (H) changes continuously; and the gene expression levels of nonylphenol (NP)-treated and those of control embryos were significantly different. Moreover, Methylation levels ofGATA1gene in NP-treated embryos were higher than those in control embryos, indicating that NP affectedGATA1methylation.ConclusionsOur study provides cues for further studying the roles ofGATA1 gene in fish development, and suggested a potential molecular mechanism by which NP leads to abnormal development of fish embryos.
The lung microbiota in Korean patients with non-tuberculous mycobacterial pulmonary disease
Authors: Kang Sung-Yoon , Kim Hyojung , Jung Sungwon , Lee Sang Min , Lee Sang Pyo 
Published: March 2021

Abstract
Background
The microbiota of the lower respiratory tract in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD) has not been fully evaluated. We explored the role of the lung microbiota in NTM-PD by analyzing protected specimen brushing (PSB) and bronchial washing samples from patients with NTM-PD obtained using a flexible bronchoscope.

Results
Bronchial washing and PSB samples from the NTM-PD group tended to have fewer OTUs and lower Chao1 richness values compared with those from the control group. In both bronchial washing and PSB samples, beta diversity was significantly lower in the NTM-PD group than in the control group (P = 2.25E-6 and P = 4.13E-4, respectively). Principal component analysis showed that the PSBs and bronchial washings exhibited similar patterns within each group but differed between the two groups. The volcano plots indicated differences in several phyla and genera between the two groups.

Conclusions
The lower respiratory tract of patients with NTM-PD has a unique microbiota distribution that is low in richness/diversity.
Body perception disturbances in women with pregnancy-related lumbopelvic pain and their role in the persistence of pain postpartum
Authors: Goossens Nina , Geraerts Inge , Vandenplas Lizelotte , Van Veldhoven Zahra , Asnong Anne , Janssens Lotte 
Published: March 2021

Abstract
Background
Lumbopelvic pain (LPP) is common during pregnancy and can have long-lasting negative consequences in terms of disability and reduced quality of life. Therefore, it is crucial to identify women at risk of having pregnancy-related LPP after childbirth. This study aimed to investigate the association between body perception, pain intensity, and disability in women with pregnancy-related LPP during late pregnancy and postpartum, and to study whether a disturbed body perception during late pregnancy predicted having postpartum LPP.

Methods
A prospective cohort study in 130 primiparous women (median age = 30 years) was performed. Pain intensity, disability, and lumbopelvic body perception during the last month of pregnancy and 6 weeks postpartum were assessed with the Numerical Pain Rating Scale (NPRS), Oswestry Disability Index, and Fremantle Back Awareness Questionnaire, respectively. Having pregnancy-related LPP was defined as an NPRS score ≥ 1/10. At both timepoints, women were categorized into three groups; pain-free, LPP with low disability, and LPP with high disability (based on Oswestry Disability Index scores). At each timepoint, body perception was compared between groups, and correlations between body perception, pain intensity, and disability were evaluated in women with LPP by using non-parametric tests. Logistic regression analysis was used to determine whether body perception during the last month of pregnancy predicted the presence of LPP 6 weeks postpartum.

Results
Women with LPP at the end of pregnancy, and 6 weeks postpartum reported a more disturbed body perception compared to pain-free women (p ≤ 0.005). Greater body perception disturbance correlated with higher pain intensity (σ = 0.266, p = 0.008) and disability (σ = 0.472, p < 0.001) during late pregnancy, and with pain intensity 6 weeks postpartum (σ = 0.403, p = 0.015). A disturbed body perception during late pregnancy nearly significantly predicted having postpartum LPP (Odds Ratio = 1.231, p = 0.052).

Conclusions
Body perception disturbance was greater in women experiencing LPP during late pregnancy and postpartum compared to pain-free women, and correlated with pain intensity and disability. Though non-significant (p = 0.052), the results of the regression analysis suggest that greater body perception disturbance during late pregnancy might predict having LPP postpartum. However, future studies should follow up on this.