bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astrocytes lure CXCR2-expressing CD4
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T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis
Authors: Khaw Yee Ming , Tierney Abbey , Cunningham Claire , Soto-Díaz Katiria , Kang Eunjoo , Steelman Andrew J. , Inoue Makoto 
Published: February 2021

Significance
Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and neuronal damage. While T cells are consistently detected in the gray matter of human MS samples, they are rarely seen in the gray matter of the most common mouse model of MS. Here, we show a modified mouse model that is characterized by a high degree of neuronal damage, T cell infiltration, and reactive gliosis in spinal cord gray matter. Using conditional knockout mice, we show that T cell migration to spinal cord gray matter depends on T cell expression of CXCR2 and astrocyte expression of TAK1-mediated chemokines such as CXCL1.
The zebrafishgrimemutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm
Authors: Koopman Charlotte D. , De Angelis Jessica , Iyer Swati P. , Verkerk Arie O. , Da Silva Jason , Berecki Geza , Jeanes Angela , Baillie Gregory J. , Paterson Scott , Uribe Veronica , Ehrlich Ophelia V. , Robinson Samuel D. , Garric Laurence , Petrou Steven , Simons Cas , Vetter Irina , Hogan Benjamin M. , de Boer Teun P. , Bakkers Jeroen , Smith Kelly A. 
Published: February 2021

SignificanceThe heart initiates rhythmic contractions early during development. A unique zebrafish mutant with specific cardiac arrhythmia phenotypes was identified and mutation of the uncharacterizedtmem161bgene shown to be causative. Tmem161b knockout mice are perinatal lethal and isolated embryonic cardiomyocytes exhibit arrhythmic Ca2+oscillations, suggesting functional conservation. Protein localization studies show Tmem161b is expressed in excitable cells and at cardiomyocyte plasma membranes. Imaging of in vivo action potentials showstmem161bmutants have prolonged action potential repolarization. Patch-clamping of isolated cardiomyocytes confirms prolonged action potential repolarization and shows increased Ca2+and K+currents are likely the cause of altered action potential morphology. This suggests Tmem161b is a new conserved regulator of cardiac rhythm by inhibiting Ca2+and K+currents.
Pathogen disgust sensitivity protects against infection in a high pathogen environment
Authors: Cepon-Robins Tara J. , Blackwell Aaron D. , Gildner Theresa E. , Liebert Melissa A. , Urlacher Samuel S. , Madimenos Felicia C. , Eick Geeta N. , Snodgrass J. Josh , Sugiyama Lawrence S. 
Published: February 2021

SignificanceDisgust likely evolved to regulate exposure to pathogen-related stimuli and behaviors. One key prediction, that individuals with greater pathogen disgust sensitivity (PDS) will be exposed to fewer pathogens and thus suffer fewer infections, has never been tested directly. To function adaptively, PDS must respond to the local cost/benefit context of avoidance, but this too has been undertested. We provide a test of these predictions among an Indigenous population with notable variation in PDS, infection, and infrastructure. We document predicted negative associations between PDS and pathogen exposure, while illuminating complex, multidirectional relationships among disgust, infection, and environmental variation. Our findings support the hypothesis that disgust functions to regulate pathogen exposure, demonstrating the importance of evolved psychological mechanisms in disease avoidance.
SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation
Authors: Haseeb Abdul , Kc Ranjan , Angelozzi Marco , de Charleroy Charles , Rux Danielle , Tower Robert J. , Yao Lutian , Pellegrino da Silva Renata , Pacifici Maurizio , Qin Ling , Lefebvre Véronique 
Published: February 2021

SignificanceCartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints. Chondrocytes build cartilage in development, governed by the transcription factor SOX9. Using mouse models and transcriptome profiling approaches, we show here that SOX9 also has key roles to maintain growth plates open postnatally and to protect adult articular cartilage from osteoarthritic degradation. In particular, SOX9 safeguards the lineage fate of chondrocytes by preventing their dedifferentiation into skeletogenic mesenchymal progenitors followed by redifferentiation into osteoblasts. These findings provide insights into cellular plasticity and its molecular control in developmental, physiological, and pathological processes within and beyond the skeletal system.
Double inhibition and activation mechanisms of Ephexin family RhoGEFs
Authors: Zhang Meng , Lin Lin , Wang Chao , Zhu Jinwei 
Published: February 2021

Significance
Ephexin family guanine nucleotide exchange factors (GEFs) act downstream of Eph signaling to regulate cytoskeletal dynamics, playing critical roles in diverse cellular processes. To achieve precise regulation of Eph signaling, the GEF activities of Ephexins need to be tightly controlled. We here present the crystal structures of autoinhibited Ephexin4, which reveal that both N- and C-terminal fragments directly contact with and inhibit the DH catalytic domain of Ephexin4. This double inhibition mechanism may be commonly utilized by other Ephexins and SGEF. Phosphorylation of a conserved tyrosine at its N terminus and association of PDZ protein(s) to its C-terminal PDZ-binding motif may relieve the autoinhibited Ephexin4. These results reveal versatile autoinhibitory mechanisms that fine-tune the GEF activities of Ephexin family RhoGEFs.
Effect of surface roughness on the fatigue failure and evaluation of TC17 titanium alloy
Authors: Jinlong Wang , Wenjie Peng , Jing Yu , Jingsi Wang , Mingchao Ding , Yuanliang Zhang 
Published: February 2021

This paper is focused on the investigation of fatigue failure mechanism for TC17 with surface roughness, which is the quantitative expression of surface micro-scratch. First, the designed fatigue tests for TC17 with different surface conditions are carried out to investigate the mechanism of fatigue failure behavior for TC17 with surface roughness. A modified formula is developed to evaluate the fatigue limit of TC17. Then, with the comprehensive application of S–N curve models and test results, the new finding of model parameters is adopted, leading to a fatigue life model of TC17 with surface roughness. Study of fatigue evaluation model of TC17 with surface roughness is significant in theoretical and engineering fatigue study. GRAPHICAL ABSTRACT
A cheap and accurate technique of measuring the rolling time of cylinders
Authors: Panagiotides N 
Published: February 2021

Abstract
Measuring time of motion using photogates is a good solution when the moving object has plane surfaces or when you can put upon it a plane surface object, which acts as a beam stopper. There are however situations where other devices, and in particular micro-switches, although they are much cheaper than photogates, perform at least as well as photogates. In this frontline, I describe how we can construct an inclined plane equipped with micro-switches and how we can use it in experiments involving rolling cylinders.
Exploration And Analysis of The Integration of Civil Engineering Technology and Computer Under New Technical Conditions
Authors: Zhang Aiguo 
Published: February 2021

Abstract
Due to the objective existence of natural disasters such as typhoon, earthquake, fire and flood, the performance of engineering structure needs to face such small probability and large load. It is a very difficult and unrealistic method to conduct experiments to verify. First, it is impossible to fully simulate the parameter variation bar; second, the cost of physical test is too high; third, it is dangerous to destroy the experiment and the equipment is difficult to keep up with it. The computer simulation technology can simulate the whole process from deformation to collapse of civil engineering structures of prototype size under the action of disaster load on the computer, so as to reveal the links and factors of unsafe structure, thus greatly improving the reliability of civil engineering.
Research on Innovative Application of Artistic Characteristics of Building Decoration Materials in Interior Design Based on Big Data
Authors: Cao Chunna 
Published: February 2021

Abstract
In the 21st century, people have entered the era of big data. People’s life is inseparable from the comparison of big data mining technology, including Building Decoration Materials (hereinafter referred to as BDM). Through big data technology, we can select more suitable BDM, which can improve people’s artistic expression level. The artistic characteristics of decorative materials can show a certain artistic beauty, which fully shows people’s artistic wisdom and level. However, with the continuous improvement of appreciation level, the traditional method of strengthening the indoor aesthetic feeling only by the artistic characteristics of decorative materials has failed to meet the requirements of people. Therefore, it is necessary to fully combine the visual experience of decorative materials to improve the artistic characteristics. This paper analyzes the decorative materials in color, texture, texture, specifications and other aspects of visual performance, which can better enhance the artistic characteristics of Interior design (hereinafter referred to as ID). Finally, this paper puts forward some practical cases.
Research on the Design of Intelligent Energy Efficiency Management System for Ships Based on Computer Big Data Platform
Authors: Li Fangxuan , Gao Wenxue 
Published: February 2021

Abstract
In the process of protecting ecological environment, constructing ecological civilization and constructing harmonious environment between man and nature, energy efficiency management is our only way. In this paper, the design of ship intelligent energy efficiency management system using computer big data is introduced from three main components, and the functions of the main system are given.
Research on Global Path Planning of Artificial Intelligence Robot Based on Improved Ant Colony Algorithm
Authors: Zhao Hairu , Zhou Hui , Yang Guiqin 
Published: February 2021

Abstract
With the rapid development of science and technology and the improvement of people’s living standards and enjoyment consciousness, robots have come into people’s field of vision more and more. People’s use of robots in production and life has greatly increased. As an important function of the normal use of the robot and evaluating the quality level of the robot, the careful design and optimization of the path planning is the most important. This study discusses the basic situation of robot global path planning, the application, advantages and improvement measures of ant colony algorithm in robot path planning, which provides help for the further development and popularization of robot.
Study on the Application of LSTM in Meteorological Element Prediction based on Computer Software
Authors: Wang Han , Li Ling 
Published: February 2021

Abstract
The 21st century is the era of big data. With the rapid development of computer technology, we can store more meteorological data, which increases the meteorological data. As people put forward higher requirements for meteorological information, we need to collect and forecast abundant meteorological laws. With the rapid development of computer technology, deep learning has opened a new era of artificial intelligence. Deep learning technology has brought opportunities to the development of meteorological forecasting technology, which has played an important role in basic weather forecast, economic activities and disaster prevention in China. First of all, this paper analyzes the important role of meteorological elements prediction. Then, this paper analyzes the deep learning LSTM algorithm. Finally, this paper makes an empirical analysis.
Research on the Intelligent Building Electrical Monitoring System Based on Computer Web
Authors: Dong Juan 
Published: February 2021

Abstract
With the development of computer information technology, the traditional building electrical monitoring system has been unable to meet the needs of users. However, the automation degree of the electrical equipment in the current intelligent building is also low. Especially for the electrical monitoring system, there is no convenient and real-time management and service architecture, so there is still a large room for improvement. Based on this, this paper first analyses the intelligent building electrical monitoring system based on Web, then studies the related technology of intelligent building web monitoring system development, and finally gives the implementation strategy of intelligent building electrical monitoring system based on computer web.
Research and Discussion on Specialty Construction of Experimental Technology for New Energy Vehicles
Authors: Liu Lesheng 
Published: February 2021

Abstract
The reform of the mechanism and performance of the internal combustion engine in the traditional automobile industry has always been the main goal in the environmental protection strategy. In recent years, people have proposed experimental technologies for new energy vehicles[1]. Facts have proved that new energy vehicles have great advantages in energy consumption and environmental pollution prevention. Because of this factor, the space for new energy vehicles to play in the automotive industry is constantly growing. Some emerging automobile-related companies are also working hard to find research and development methods for new energy vehicles. This phenomenon has also led to a sharp increase in the demand for talents after the launch of new energy vehicles. Therefore, the current obsolete automobile research and development profession must undergo transformational development to be able to adapt to the needs of society. The construction of the new energy vehicle test technology specialty is imminent.
Research on New Methods and Technologies of Engineering and Environmental Geophysical Exploration Based on Internet of Things
Authors: Ma Ming 
Published: February 2021

Abstract
After years of development, geophysical exploration in macro programming environment through the Internet of things has become a basic international model and has been widely valued and studied. Because of its special advantages in practice, the research of new geophysical methods and technologies has been introduced into the education of computer, law, economics, engineering and other disciplines. With the development of network technology, geophysical exploration of engineering and environment has been combined with network technology, forming problem-oriented research in network environment. In the continuous exploration, there is a stable inertia and activity process between the various elements, which can effectively find problems and solve problems. Therefore, through the Internet of things, this effective bridge combines engineering and environment with “new geophysical methods and technologies” to explore and develop new fields[1].
Research on Comprehensive Prevention and Control Technology of Overlying Goaf Water under Complex Conditions Based on Computer
Authors: Qu Nianhua , Wang Haitao , Song Xin , Cheng Tong , Wang Yajun 
Published: February 2021

Abstract
With the gradual depletion of the upper resources of some coal mines with a long mining life, the operations of these coal mines gradually want to transfer to the lower coal seam. However, the mining activities of the upper coal seam have produced a large number of goafs, and due to human and natural factors, there are serious water problems in the goaf, and there is a big security risk. Based on this, this paper first studies the computer-based coal mining and overlying goaf exploration technology, and then gives the comprehensive prevention and control strategy of overlying goaf water under complex conditions based on computer.
Design Analysis of Natural Lighting and Ventilation of Underground Garage with the Computer-aided Technology
Authors: Yu Qingli 
Published: February 2021

Abstract
In the analysis of the lighting and ventilation design mode of the underground garage, it is necessary to take the natural green environmental protection standard design as the main thought and pay attention to the influence of lighting on the car. According to the data simulation method and the overall design scheme standard, the specific range of numerical simulation standard is determined. Through the analysis of airflow change, distribution mode, air volume, carbon dioxide, carbon monoxide concentration ratio level of underground garage, we can determine the actual ventilation design standards of underground garage and value more on the implementation of natural lighting and ventilation design scheme under green building mode. This paper analyzes the practical natural lighting application design method of green building underground garage with the computer-aided technology, combines the development of green building and building energy saving, lays emphasis on the ventilation and sewage effect of underground garage, strengthens the reasonable allocation and application of the overall lighting and ventilation of underground garage and finally clarifies the operation standard and design effect.
Research on Electrical Testing System of New Energy Vehicle Based on Computer
Authors: Zheng Tuo 
Published: February 2021

Abstract
According to the design structure and working characteristics of the whole vehicle electrical system of new energy vehicle, combined with the deep application of computer in PLC programming and sensor, this paper studies the detection target, detection principle, detection method and some instruments of electrical insulation performance and electrical working performance, in order to provide some reference for the development and progress of new energy vehicle electrical system.
Microgrid Computer Distributed Voltage Control Strategy for Multi-inverters
Authors: Fei Wang 
Published: February 2021

Abstract
We always emphasize the shortage of some domestic resources. In our cognitive field, it seems that electricity is an inexhaustible energy. In fact, power resources are also renewable resources produced with the assistance of the power system. The micro-grid we often say is a protective measure with auxiliary functions that can solve the problem of electronic failure[1]. In addition, for the distribution of distributed energy, microgrid technology can also help it to connect in a wide range. However, looking at some of the system structures, we will find that the main and most difficult problem is that it is difficult to mobilize the integrated control of the power generated by multiple distributed inverters through the computer. From this point of view, the research on the distributed voltage control of the microgrid computer oriented to multiple or multiple inverters is imminent.
Design and Research of the Automatic Hydraulic Testing and Testing Device for Gas Cylinder
Authors: Huang Wei , Zhou Zhou 
Published: February 2021

Abstract
Gas cylinder is a typical storage and transportation equipment, which plays an important role in the national economy. Cylinder hydrostatic test is the core project in cylinder quality inspection, which mainly refers to GB/T 9251-2011 cylinder hydrostatic test method and CGA C-1-2009 methods for pressure testing compressed gas cylinders. These two standards are hydrostatic test by external measurement, which is mainly used to check whether the overpressure bearing capacity of gas cylinder meets the requirements. Hydrostatic test is an essential part of gas cylinder production. Therefore, we must produce a good hydrostatic test device, which will directly affect the reliability, production efficiency and testing efficiency of the gas cylinder quality test results. Firstly, this paper analyzes the detection method of gas cylinder. Then, this paper designs the flow chart of gas cylinder hydraulic testing. At last, this paper designs the testing device of cylinder water pressure detection.
Research on Fire Alarm Monitoring System Based on Computer
Authors: Bai Xutao , Lu Hairong 
Published: February 2021

Abstract
With the rapid development of urbanization, the number of buildings is increasing rapidly, and the density of buildings increases the difficulty of fire protection. Therefore, more and more fires occur in the city, which is not conducive to the improvement of people’s daily safety and quality of life. In order to ensure the quality of urban construction, the construction of fire alarm monitoring system is particularly important. In the new era of social development, we will comprehensively improve the traditional and single monitoring and alarm functions, integrate the functions of monitoring, linkage, alarm, regulation and prevention, and establish a comprehensive and intelligent fire alarm and monitoring system. With the rapid development of network technology, the realization of fire alarm monitoring system is inseparable from the support of network system. On this basis, we should strengthen the research on alarm monitoring system, realize the good integration of network technology and fire alarm monitoring system, constantly improve it, and play its maximum role to improve the quality of fire protection work, so as to contribute to the modernization of the city.
Research on the application of computer information management system in project cost prediction
Authors: Chen Yanhua , Yu Zhihua , Liu Jinchao 
Published: February 2021

Abstract
“project cost” refers to how to build or change an engineering structure, so that it can more effectively achieve the established objectives of the project, the project cost is often referred to in the project to make the relevant project should have what kind of structure selection. With the advent of the information age, the engineering structure of a project has an increasingly important impact on its management effectiveness. In this paper, a management guru mintzberg’s theory as the breakthrough point, analyzes the engineering cost in computer information management the important role of engineering cost, and how to effectively achieve the project cost and the environment of good match, good configuration of engineering parameters, to meet the needs of the engineering of computer information management effectiveness.
Probe Development of Borehole Resistivity Measurement in Coal Mine
Authors: Ma Bin 
Published: February 2021

Abstract
In order to better serve the disaster prevention and control work, a method of measuring the borehole resistivity is proposed in the fine geological exploration and coal mining. It measures the resistivity variation curve on the borehole profile, so as to divide the coal field strata and identify the geological anomaly areas. Firstly, we have designed a device which can generate a frequency of 0-1 MHz, based on the measurement model of a symmetrical four stage device. Then the automatic range conversion module is designed, including full differential amplifier circuit and high-speed AD circuit signal acquisition unit. Finally, the device coefficient K of the probe tube is calibrated by linear regression analysis. The performance test results show that the measurement error of resistivity probe tube is 0.2%, which can meet the needs of fine detection in coal mine borehole.