bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Updated Review of the Pre-Clinical Role of microRNAs and their
Contribution to Colorectal Cancer
Authors: Dastmalchi Narges , Safaralizadeh Reza , Teimourian Shahram 
Published: December 2021

:
Colorectal cancer (CRC) is one of the main causes of malignancy-related
mortality worldwide. It was well-identified that microRNAs (miRNAs) decisively participate
in cellular biological pathways; in a way that their deregulated expression causes CRC
progression. miRNAs can control the translation and degradation of mRNAs by binding to
various molecular targets involved in different biological processes, including growth,
apoptosis, cell cycle, autophagy, angiogenesis, metastasis, etc. The functions of these
dysregulated miRNAs may be either oncogenic or tumor-suppressive. Therefore, these
miRNAs can be contributed to prognostic, diagnostic, and therapeutic approaches in CRC.
In this study, we reviewed the tumor-suppressive and oncogenic functions of miRNAs in
CRC and assessed their molecular activities in CRC development. However, further
investigation for the involvement of dysregulated miRNAs in CRC progression is required.
Amniotic Fluid Stem Cells: What They Are and What They Can Become
Authors: Rosner Margit , Hengstschläger Markus 
Published: December 2021

:
In the last two decades, fetal amniotic fluid stem cells progressively attracted attention
in the context of both basic research and the development of innovative therapeutic concepts. They
exhibit broadly multipotent plasticity with the ability to differentiate into cells of all three embryonic
germ layers and low immunogenicity. They are convenient to maintain, highly proliferative, genomically
stable, non-tumorigenic, perfectly amenable to genetic modifications, and do not raise
ethical concerns. However, it is important to note that among the various fetal amniotic fluid cells,
only c-Kit+ amniotic fluid stem cells represent a distinct entity showing the full spectrum of these
features. Since amniotic fluid additionally contains numerous terminally differentiated cells and
progenitor cells with more limited differentiation potentials, it is of highest relevance to always precisely
describe the isolation procedure and characteristics of the used amniotic fluid-derived cell
type. It is of obvious interest for scientists, clinicians, and patients alike to be able to rely on up-todate
and concisely separated pictures of the utilities as well as the limitations of terminally differentiated
amniotic fluid cells, amniotic fluid-derived progenitor cells, and c-Kit+ amniotic fluid stem
cells, to drive these distinct cellular models towards as many individual clinical applications as possible.
Increasing Participation Rates in Germany’s Skin Cancer Screening Program (HELIOS): Protocol for a Mixed Methods Study
Authors: Steeb Theresa , Heppt Markus V , Erdmann Michael , Wessely Anja , Klug Stefanie J , Berking Carola 
Published: December 2021

Background
In 2008, a nationwide skin cancer screening (SCS) program was implemented in Germany. However, participation rates remain low.

Objective
The overall objective of the HELIOS study is to identify subgroup-specific invitation and communication strategies to increase informed SCS participation in Germany.

Methods
Focus group discussions will be performed in Erlangen, Germany, to explore potential invitation and communication strategies as well as possible barriers and motivating factors to participate in SCS. Male and female patients of different age groups who have already been diagnosed with skin cancer, as well as participants without a prior diagnosis of skin cancer, will be invited. Based on these results, an online questionnaire will be developed to identify subgroup-specific invitation strategies. A random sample of 2500 persons from the general population aged >35 years from the Munich area will be contacted to complete the questionnaire. Besides descriptive analysis, multinomial logistic regression will be performed. Additionally, a cluster analysis will be conducted to discover patterns or similarities among the participants.

Results
Recruitment for the focus group studies started in February 2021 and is ongoing. As of August 2021, we have enrolled 39 participants. We expect to end enrollment in the qualitative study in September 2021 and to finish the analysis in December 2021. The second part of the study will then start in January 2022.

Conclusions
The results of this project will enable us to derive improved and more efficient invitation and communication strategies for SCS. These may be implemented in the future to facilitate increased SCS uptake and early skin cancer detection.

International Registered Report Identifier (IRRID)
DERR1-10.2196/31860
Modification of Fishbone-Based Hydroxyapatite with MnFe<sub>2</sub>O<sub>4</sub> for Efficient Adsorption of Cd(II) and Ni(II) from Aqueous Solution
Authors: Hariani Poedji Loekitowati , Rachmat Addy , Said Muhammad , Salni Salni 
Published: December 2021

Due to their toxicity, Cd(II) and Ni(II) ions in the environment are severe. The hydroxyapatite composite was improved with magnetic MnFe2O4 to remove Cd(II) and Ni(II) ions from an aqueous solution. Hydroxyapatite was extracted from Snakehead (Channa striata) fish bones via alkaline-heat treatment. The hydroxyapatite/MnFe2O4 composite performance was analyzed through XRD, FTIR, SEM-EDS, BET analysis, and VSM, and the results reveal that the hydroxyapatite/MnFe2O4 composite shows good magnetic properties of 21.95 emu/g. The kinetics evaluation confirmed that the pseudo-second-order kinetics model was more suitable to describe the adsorption of Cd(II) and Ni(II) ions by hydroxyapatite/MnFe2O4 composite from the solution. The Langmuir isotherm model was suitable to describe the adsorption process of the Cd(II) and Ni(II) ions, where the adsorption capacities for Cd(II) and Ni(II) are 54.3 and 47.4 mg/g, respectively. Desorption of Cd(II) and Ni(II) ions from hydroxyapatite/MnFe2O4 composite using NaCl as the eluent was more effective than EDTA. The findings of this study indicate that hydroxyapatite/MnFe2O4 can reduce Cd(II) and Ni(II) ions in wastewater so that it can recover natural resources.
SiJasPro : Sistem Informasi Jasa Proyek Dalam Meningkatkan Kepuasan Pelanggan
Authors: Hasanudin Muhaimin , Ramayanti Desi 
Published: December 2021

<em>Sektor penyedia jasa tenaga kerja memiliki peranan dalam upaya mendukung pelayanan kepada pelanggan. Namun di sisi lain, ketika pelanggan ingin membangun atau merenovasi rumah kesulitan dalam mencari material bangunan dan penyedia jasa proyek (tukang bangunan) dalam satu sistem. Penyedia jasa memberikan jasa keahlian dalam membangun dan merenovasi rumah berdasarkan permintaan pelanggan. Berdasarkan masalah tersebut, peneliti melakukan perancangan Sistem Informasi Jasa Proyek bertujuan memfasilitasi pelanggan, penyedia jasa dan penjual dalam satu sistem disebut eMarketplace Si JasPro. Diharapkan dapat membantu dan membuka peluang usaha bagi umkm material bangunan dan penyedia jasa bangunan, mempermudah pelanggan membeli kebutuhan material dan mencari penyedia jasa, pelanggan dapat mengetahui harga dan jasa material sehingga bisa memperkirakan kebutuhan yang diinginkan, pelanggan bisa berkonsultasi dengan konsultan bangunan, memberikan sketsa kerja dan memberikan komentar dari hasil kerja penyedia jasa sehingga dapat meningkatkan pelayanan pelanggan. Dalam mengembangkan aplikasi SI JasPro menggunakan metode Rapid Application Development (RAD). Aplikasi Si JasPro dapat mengintegrasikan pelanggan, penjual dan penyedia jasa dalam satu sistem, mempermudah para pengguna sistem dalam mengakses informasi dan mengelola data secara terkomputerisasi</em>
MAKNA KEBAHAGIAAN PADA MAHASISWA PEREMPUAN DI ERA MILLENNIALS
Authors: Ariska Desi , Situmorang Nina Zulida , Hanif Mifta , Sulistiawan Agus 
Published: December 2021

Kebahagiaan merupakan suatu hal yang penting dalam kehidupan individu tanpa melihat batas usia dan jenis kelamin, kebahagiaan merupakan wujud kesempurnaan, sehingga banyak orang yang berusaha mewujudkannya.kebahagiaan adalah perasaan positif yang akan mendorong seseorang untuk melakukan berbagai tindakan yang positif. Penelitian ini bertujuan untuk menganalisis makna kebahagiaan mahasiswa perempuan di Yogyakarta. Sejumlah 74 mahasiswa di Yogyakarta mengisi kuesioner dengan pertanyaan terbuka dan informasi mengenai data diri. Analisis yang digunakan dalam penelitian ini menggunakan kombinasi metode kualitatif dengan pendekatan indigenous psychology, pendekatan dilihat dari sudut pandang budaya lokal, yang memungkinkan untuk melihat setiap fenomena sesuai dengan konteks terkait. Respon dikategorikan berdasarkan persamaan tema. Hasil yang diperoleh dari kategorisasi makna kebahagiaan pada perempuan adalah peristiwa yang berhubungan dengan nilai Kebermanfataan,Religiusitas, kesuksesan, keluarga, kenyamanan, dicintai, sehat, dan lain-lain.
FEAR OF CRIME DITINJAU DARI GENDER, USIA, ETNIS DAN SOSIO EKONOMI
Authors: Sa'diyah Siti Alifatus , Sudrajat Ahmad Adi , Marisa Pugud Aujian Arum , Hijriyati Naena , Putri Sheilla Khairunnisa Rahardi , Duwiyanti Arie 
Published: December 2021

Penelitian ini bertujuan untuk mengetahui tingkat fear of crime berdasarkan gender, usia, etnis, dan juga sosio-ekonomi di Surabaya. Responden penelitian adalah laki – laki dan perempuan remaja dengan rentang usia 12 – 18 tahun dan dewasa dengan rentang usia 19 – 40 tahun serta berdomisili di Surabaya. Responden adalah etnis Jawa dan Madura, dengan kriteria sosio-ekonomi bawah, menengah dan atas yang berjumlah 160 orang. Penelitian ini menggunakan jenis penelitian kuantitatif dengan menggunakan metode survey diskriptif dan komparatif, dimana jenis metode tersebut digunakan untuk menggambarkan atau menganilisis suatu fenomena yang sedang diteliti. Penelitian ini menggunakan skala fear of crime. Adapaun metode yang digunakan untuk menganalisis data adalah One-Sample T-Test dan diolah menggunakan SPSS. Hasil penelitian menunjukkan bahwa dari 160 responden yang berpartisipasi dalam penelitian fear of crime di Surabaya terdapat 107 responden dengan tingkat fear of crime tinggi, 32 responden dengan tingkat fear of crime sedang, dan 21 responden dengan tingkat fear of crime yang rendah. Penelitian ini juga menunjukkan bahwa tingkat fear of crime pada perempuan lebih tinggi daripada laki-laki, sedangkan pada etnis, sosio ekonomi dan usia tidak terdapat perbedaan yang significan.
STEREOTIP “PIDIE KRIET” TERHADAP PERILAKU ALTRUISME
Authors: Amna Zaujatul - , Aflah Ruhul 
Published: December 2021

“Pidie Kriet” diartikan sebagai “Pidie pelit”. “Pidie kriet” merupakan suatu istilah yang melekat pada masyarakat Pidie, Aceh, Indonesia. Istilah tersebut masih berkembang hingga saat ini terutama di masyarakat Pidie, dimana stereotip tersebut berpengaruh bagi individu karena diasosikan seseorang yang berasal dari pidie diasosikan dengan stereotip dengan orang yang pelit. Hal ini tentunya akan memengaruhi perilaku altruisme dari individu tersebut. penelitian ini bertujuan untuk mengetahui hubungan antara stereotip “Pidie Kriet” dengan perilaku altruism, yang dilakukan terhadap 120 mahasiswa Pidie yang dipilih dengan menggunakan teknik sampling insidental. Hasil analisis menunjukkan terdapat hubungan negatif dan signifikan antara stereotip “Pidie Kriet” dengan perilaku altruism (p=0,014, r=0,227). Hal ini dapat diartikan semakin tinggi stereotype pidie kriet dalam diri individu, maka semakin rendah perilaku altruismenya, dan juga sebaliknya. Hasil penelitian juga menunjukkan pada umumnya subjek memiliki tingkat perilaku altruisme yang tinggi dan stereotip “pidie kriet” yang rendah dalam dirinya. Dengan demikian, dapat dikatakan bahwa stereotip "Pidie Kriet" tidak terlalu memengaruhi perilaku altruisme mahasiswa Pidie tersebut.
ANALISA DESKRIPTIF KOMITMEN ORGANISASI PADA KARYAWAN GF FOUNDATION
Authors: Jupitawati Ratna , Kadiyono Anissa Lestari 
Published: December 2021

Pada kesempatan ini peneliti tertarik untuk melakukan penelitian tentang komitmen karyawan pada organisasi kemanusiaan GF Foundation, yaitu organisasi yang menyalurkan donasi pada proyek kemanusiaan baik berskala nasional maupun internasional. Penelitian yang dilakukan bersifat deskriptif yaitu bertujuan ingin mengetahui seberapa tinggi komitmen yang dimiliki dari para karyawannya. Kemudian dilihat juga komitmen yang paling menonjol diantara tiga komitmen yang digali yaitu Afektif Komitmen, Kontinuitas Komitmen dan Normatif Komitmen. Sebanyak 31 personel yang merupakan karyawan tetap Golden Future diambil datanya dengan mengisi kuesioner dan wawancara. Dari data yang diperoleh terlihat bahwa Afektif Komitmen lebih menonjol dibandingkan yang lainnya, kemudian Normatif Komitmen dan Kontinuitas Komitmen. Begitu pula halnya berdasarkan jenis kelamin terlihat pula bahwa antara karyawan laki-laki dan perempuan kedua-keduanya memiliki Afektif Komitment yang sama-sama tinggi.
DIFFERENCES OF LIFE SATISFACTION AMONG ACEHNESE UNIVERSITY STUDENTS IN MALAYSIA MALE AND FEMALE
Authors: Hayati Pelita , SIM CHE CHEW , Fitria Ida 
Published: December 2021

International student mobility has over the past 10-15 years become an increasingly, more students from across the world are able to participate in higher education abroad, especially those from countries with rapidly growing economies in Asian country (i.e Malaysia, Indonesia, etc). The high educational ranking of Malaysia is appealing to many Acehnese students including to study in Malaysia. Studying abroad can be a challenge having to adapt and adjust oneself to a whole new environment, culture, language, education system, lifestyle, and new friends. This study aims to investigate the levels of life satisfaction among Acehnese university students in Malaysia male and female. T-test analysis has performed to analyze the mean life satisfaction between male and female students. The result of this study reveals there was no significant difference in life satisfaction across gender. Further discussions are displayed in full view of this study.
Biodiversidad en cifras: avances en el conocimiento de especies en Costa Rica
Authors: Tania Bermúdez Rojas  , Vilma Obando Acuña  
Published: December 2021

Para conservar y utilizar sosteniblemente la biodiversidad es fundamental conocerla, por ello se presentan los datos en cifras de algunos grupos taxonómicos de Costa Rica. La información fue recopilada, analizada y sistematizada en talleres, consulta a especialistas y revisión de publicaciones. Se presenta la información de forma integrada y sencilla, comparando las cifras del 2014 con el 2019 como actualización de los siguientes grupos taxonómicos: insectos, hongos, líquenes, plantas, peces, anfibios, reptiles, aves y mamíferos. Además, se mencionan los principales vacíos de información. Entre los principales resultados observamos que para el 2019 aumentó el número en la mayoría de los grupos de vertebrados, siendo los peces los de mayor incremento; para anfibios, reptiles, aves y mamíferos, el aumento fue menor debido a las revisiones taxonómicas que permitió el ingreso, pero también la eliminación de algunos registros. El número de insectos, así como los artrópodos están en revisión. El número de plantas y hongos disminuyó, por la rectificación taxonómica de los dos grupos. Sin embargo, separando hongos de líquenes, este último presenta un incremento significativo. La información generada es fundamental para comenzar a generar datos serios, confiables y actualizados sobre nuestra biodiversidad.
TRADITIONAL NORTHERN SELKUP TOY
Authors: Степанова Ольга Борисовна 
Published: December 2021

Традиционная игрушка северных селькупов, сегодня ими почти забытая, до сих пор никем не исследовалась. Между тем, она представляет собой яркий фрагмент традиционной селькупской культуры. Исследование ставило своей задачей вернуть селькупскому народу этот элемент его культуры в форме научного описания. На основе главным образом музейных материалов и отчасти полевых материалов автора были выявлены и рассмотрены пять типов игрушки северных селькупов, включая шесть видов куклы. Из-за нехватки селькупского материала в исследовании активно использовался метод научной реконструкции. Описания зафиксированных у селькупов типов и видов игрушки воссоздавались по материалам игрушки соседних народов. Попутно устанавливалось, какие традиции — западносибирские и восточносибирские — оказывали влияние на формирование облика того или иного типа/вида игрушки у селькупов. Был рассмотрен вопрос о связи североселькупской игрушки — вещи утилитарного значения — с сакральным или, иными словами, вопрос ее символических смыслов. Автор пришла к выводу, что все типы и виды селькупской игрушки в прошлом были сакральными обрядовыми предметами, и что в семиотическом статусе игрушки соотношение «знакового» и «вещного» со временем сдвинулось в сторону «вещного». Завершенный вид исследованию придали включенные в него материалы по современному состоянию традиционной североселькупской игрушки.
The traditional toy of the northern Selkups, today almost forgotten by them, has not yet been studied by anyone. Meanwhile, it is a vivid fragment of the traditional Selkup culture. The research aimed to return this element of their culture to the Selkup people in the form of a scientific description. Based mainly on museum materials and partly from the author's field materials, five types of toys of the northern Selkups were identified and considered, including six types of dolls. Due to the lack of Selkup material, the method of scientific reconstruction was actively used in the study. Descriptions of the types and types of toys recorded by the Selkups were recreated based on the materials of toys of neighboring peoples. Along the way, it was established which traditions — West Siberian and East Siberian — influenced the formation of the appearance of a particular type / type of toy among the Selkups. The question of the connection between the North Selkup toy — a thing of utilitarian meaning — with the sacred, or, in other words, the question of its symbolic meanings, was considered. The author came to the conclusion that all types and types of Selkup toys in the past were sacred ritual objects, and that in the semiotic status of a toy, the ratio of “sign” and “thing” over time shifted towards the “thing”. The study was completed by the materials included in it on the current state of the traditional North Selkup toy.
ACTIVATION OF MENTAL ACTIVITY AS A PEDAGOGICAL CONDITION FOR THE DEVELOPMENT OF THE COGNITIVE ACTIVITY OF SENIOR PRESCHOOLERS
Authors: Грибова Елена Петровна 
Published: December 2021

Рассматривается вопрос развития познавательной активности детей старшего дошкольного возраста. Развитие данного вида активности зависит от ряда факторов, среди которых можно выделить и педагогические условия. Одним из эффективных педагогических условий выступает максимальная опора на активную мыслительную деятельность детей. Данное условие сподвигает педагогов на применение в образовательной деятельности с детьми разнообразных ситуаций, порождающих у них интеллектуальное затруднение и, как следствие, потребность разрешить и выйти из него. Показано, что данные ситуации могут быть представлены в виде кейсов (кейс-стади), эвристической беседы, «сильных» (открытых, проблемных) вопросов и др. Приведены практические примеры предлагаемых методов стимулирования познавательной активности детей.
The issue of the development of cognitive activity of senior preschoolers is considered. The development of this type of activity depends on a number of factors, among which pedagogical conditions can be distinguished. One of the effective pedagogical conditions for the development of the cognitive activity of older preschoolers is the maximum reliance on the active mental activity of children. The types of problem situations are listed: 1) situationchoice; 2) a situation of uncertainty; 3) conflict situation; 4) situation-paradox; 5) the situation with the hypothesis; 6) situation with the refutation; 7) situation-inconsistency. It is noted that the tension of an older preschooler of intellectual forces to solve tasks or search for an answer to a question is the basis for the development of his mental activity, cognitive interest and the manifestation of activity. The use of situations and questions of a problematic nature by the teacher in work with children of senior preschool age contributes to the intensification of the mental activity of children, thereby increasing their activity in the process of searching for new knowledge and information, the formation of new skills in the cognitive sphere. At the same time, the proposed methods should be used by the teacher not separately from each other, but in aggregate, since they complement each other, involving collective discussion of situations by children and the search for answers, problem solving, and productive cognitive activity. This article provides practical examples of proposed methods to stimulate children’s cognitive activity.
Switching Between Aflibercept and Ranibizumab in the Treatment of Refractory Exudative Age-related Macular Degeneration
Authors: Wichrowska Małgorzata , Kocięcki Jarosław , Suda Wojciech 
Published: December 2021

Introduction: Aflibercept and ranibizumab have become the most used drugs in the treatment of wet age-related macular degeneration. Some patients; however, do not respond to aflibercept and ranibizumab treatment. Our aim was to determine whether the switch from aflibercept to ranibizumab, and then switchback, is effective in a group of patients poorly responding to aflibercept. We assessed best corrected visual acuity, central retinal thickness, and the presence of intra- and subretinal fluid (respectively).
Material and methods: We conducted a retrospective comparative case series study. Twenty eyes of 20 patients, who had no inhibition of disease activity after at least one year of treatment with aflibercept, were included in the study. If after switch to ranibizumab the response to the drug was again inadequate, we returned to aflibercept. We divided the study population into two groups: treatment- naïve and patients who had received injections before entering the Drug Program for the Treatment of Age-Related Exudative Macular Degeneration.
Results: We observed an improvement in both best corrected visual acuity and central retinal thickness parameters, but only in the treatment-naïve group. We did not observe any statistically credible effects for sub- and intraretinal fluid in the studied groups.
Conclusions: Drug conversion may be beneficial for patients poorly responding to primary therapy. Greater improvement is seen in previously untreated patients.
The role of balanced supplementation in diet of age-related macular degeneration patients
Authors: Kusz vel Sobczuk Iwona , Święch Anna 
Published: December 2021

Aim: The aim of the article was to discuss the role of balanced supplementation in diet of age-related macular degeneration patients.
Methods: This review was carried out using comprehensive and systematic literature reports on the role of supplementation of vitamin D, vitamin C, vitamin E, vitamin B6, vitamin B12, zinc, lutein, zeaxanthin, omega-3 acid and folic acid in the prevention of AMD.
Results: Vitamins, minerals and carotenoids are essential for the proper retinal function over an inflammation and immune response modulation.
Conclusions: Vitamins, minerals and carotenoids discussed in the article have anti-inflammatory and antioxidative properties in the management of AMD progression. Accordingly, it is relevant to assure the appropriate level of these nutrients in a diet of AMD patients.