bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chapter 1.1 Tectonic history of Antarctica over the past 200 million years
Authors: Storey Bryan C. , Granot Roi 
Published: January 2021

Abstract
The tectonic evolution of Antarctica in the Mesozoic and Cenozoic eras was marked by igneous activity that formed as a result of simultaneous continental rifting and subduction processes acting during the final stages of the southward drift of Gondwana towards the South Pole. For the most part, continental rifting resulted in the progressive disintegration of the Gondwana supercontinent from Middle Jurassic times to the final isolation of Antarctica at the South Pole following the Cenozoic opening of the surrounding ocean basins, and the separation of Antarctica from South America and Australia. The initial rifting into East and West Gondwana was proceeded by emplacement of large igneous provinces preserved in present-day South America, Africa and Antarctica. Continued rifting within Antarctica did not lead to continental separation but to the development of the West Antarctic Rift System, dividing the continent into the East and West Antarctic plates, and uplift of the Transantarctic Mountains. Motion between East and West Antarctica has been accommodated by a series of discrete rifting pulses with a westward shift and concentration of the motion throughout the Cenozoic leading to crustal thinning, subsidence, elevated heat flow conditions and rift-related magmatic activity. Contemporaneous with the disintegration of Gondwana and the isolation of Antarctica, subduction processes were active along the palaeo-Pacific margin of Antarctica recorded by magmatic arcs, accretionary complexes, and forearc and back-arc basin sequences. A low in magmatic activity between 156 and 142 Ma suggests that subduction may have ceased during this time. Today, following the gradual cessation of the Antarctic rifting and surrounding subduction, the Antarctic continent is situated close to the centre of a large Antarctic Plate which, with the exception of an active margin on the northern tip of the Antarctic Peninsula, is surrounded by active spreading ridges.
Chapter 3.2a Bransfield Strait and James Ross Island: volcanology
Authors: Smellie John L. 
Published: January 2021

Abstract

Following more than 25 years of exploration and research since the last regional appraisal, the number of known subaerially exposed volcanoes in the northern Antarctic Peninsula region has more than trebled, from less than 15 to more than 50, and that total must be increased at least three-fold if seamounts in Bransfield Strait are included. Several volcanoes remain unvisited and there are relatively few detailed studies. The region includes Deception Island, the most prolific active volcano in Antarctica, and Mount Haddington, the largest volcano in Antarctica. The tectonic environment of the volcanism is more variable than elsewhere in Antarctica. Most of the volcanism is related to subduction. It includes very young ensialic marginal basin volcanism (Bransfield Strait), back-arc alkaline volcanism (James Ross Island Volcanic Group) and slab-window-related volcanism (seamount offshore of Anvers Island), as well as volcanism of uncertain origin (Anvers and Brabant islands; small volcanic centres on Livingston and Greenwich islands). Only ‘normal’ arc volcanism is not clearly represented, possibly because active subduction virtually ceased at
c.
4 Ma. The eruptive environment for the volcanism varied between subglacial, marine and subaerial but a subglacial setting is prominent, particularly in the James Ross Island Volcanic Group.
Bladder Tumor Subtype Commitment Occurs in Carcinoma In Situ Driven by Key Signaling Pathways Including ECM Remodeling
Authors: Wullweber Adrian , Strick Reiner , Lange Fabienne , Sikic Danijel , Taubert Helge , Wach Sven , Wullich Bernd , Bertz Simone , Weyerer Veronika , Stoehr Robert , Breyer Johannes , Burger Maximilian , Hartmann Arndt , Strissel Pamela L. , Eckstein Markus 
Published: January 2021

Abstract

Basal and luminal subtypes of invasive bladder tumors have significant prognostic and predictive impacts for patients. However, it remains unclear whether tumor subtype commitment occurs in noninvasive urothelial lesions or in carcinoma in situ (CIS) and which gene pathways are important for bladder tumor progression. To understand the timing of this commitment, we used gene expression and protein analysis to create a global overview of 36 separate tissues excised from a whole bladder encompassing urothelium, noninvasive urothelial lesions, CIS, and invasive carcinomas. Additionally investigated were matched CIS, noninvasive urothelial lesions, and muscle-invasive bladder cancers (MIBC) from 22 patients. The final stage of subtype commitment to either a luminal or basal MIBC occurred at the CIS transition. For all tissues combined, hierarchical clustering of subtype gene expression revealed three subtypes: “luminal,” “basal,” and a “luminal p53-/extracellular matrix (ECM)-like” phenotype of ECM-related genes enriched in tumor-associated urothelium, noninvasive urothelial lesions, and CIS, but rarely invasive, carcinomas. A separate cohort of normal urothelium from noncancer patients showed significantly lower expression of ECM-related genes compared with tumor-associated urothelium, noninvasive urothelial lesions, and CIS. A PanCancer Progression Panel of 681 genes unveiled pathways specific for the luminal p53-/ECM-like cluster, for example, ECM remodeling, angiogenesis, epithelial-to-mesenchymal transition, cellular discohesion, cell motility involved in tumor progression, and cell proliferation and oncogenic ERBB2/ERBB3 signaling for invasive carcinomas. In conclusion, this study provides insights into bladder cancer subtype commitment and associated signaling pathways, which could help predict therapy response and enhance our understanding of therapy resistance.

Significance:
This study demonstrates that CIS is the stage of commitment for determining MIBC tumor subtype, which is relevant for patient prognosis and therapy response.
Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer Therapy
Authors: Amjadi-Moheb Fatemeh , Paniri Alireza , Akhavan-Niaki Haleh 
Published: January 2021

Abstract
MYC is embedded in the transcriptional oasis of the 8q24 gene desert. A plethora of genomic elements has roles in MYC aberrant expression in cancer development by interacting with transcription factors and epigenetics regulators as well as altering the structure of chromatin at the MYC locus and tissue-specific long-range enhancer–promoter contacts. Furthermore, MYC is a master regulator of several human cancers by modulating the transcription of numerous cancer-related genes through epigenetic mechanisms. This review provides a comprehensive overview of the three-dimensional genomic organization around MYC and the role of epigenetic machinery in transcription and function of MYC as well as discusses various epigenetic-targeted therapeutic strategies in MYC-driven cancers.
Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells
Authors: Bauzone Marjolaine , Souidi Mouloud , Dessein Anne-Frédérique , Wisztorski Maxence , Vincent Audrey , Gimeno Jean-Pascal , Monté Didier , Van Seuningen Isabelle , Gespach Christian , Huet Guillemette 
Published: January 2021

Abstract

The mechanisms whereby the Hippo pathway effector YAP regulates cancer cell stemness, plasticity, and chemoresistance are not fully understood. We previously showed that in 5-fluorouracil (5-FU)–resistant colorectal cancer cells, the transcriptional coactivator YAP is differentially regulated at critical transitions connected with reversible quiescence/dormancy to promote metastasis. Here, we found that experimental YAP activation in 5-FU–sensitive and 5-FU–resistant HT29 colorectal cancer cells enhanced nuclear YAP localization and the transcript levels of the retinoic acid (RA) receptors RARα/γ and RAR target genes CYP26A1, ALDH1A3, and LGR5 through RA Response Elements (RARE). In these two cell models, constitutive YAP activation reinforced the expression of the stemness biomarkers and regulators ALDH1A3, LGR5, and OCT4. Conversely, YAP silencing, RAR/RXR inhibition by the pan-RAR antagonist BMS493, and vitamin A depletion downregulated stemness traits and self-renewal. Regarding the mechanisms engaged, proximity-dependent labeling, nuclear YAP pulldown coupled with mass spectrometry, and chromatin immunoprecipitation (ChIP)/re-ChIP experiments revealed: (i) the nuclear colocalization/interaction of YAP with RARγ and RXRs; and (ii) combined genomic co-occupancy of YAP, RARα/γ, and RXRα interactomes at proximal RAREs of LGR5 and ALDH1A3 promoters. Moreover, activation of the YAP/RAR-RXR cross-talk in colorectal cancer cells promoted RAR self-activation loops via vitamin A metabolism, RA, and active RAR ligands generated by ALDH1A3. Together, our data identify YAP as a bona fide RAR-RXR transcriptional coactivator that acts through RARE-activated stemness genes.

Implications:
Targeting the newly identified YAP/RAR-RXR cross-talk implicated in cancer cell stemness maintenance may lead to multitarget combination therapies for patients with colorectal cancer.
O-GlcNAc Transferase – An Auxiliary Factor or a Full-blown Oncogene?
Authors: Itkonen Harri M. , Loda Massimo , Mills Ian G. 
Published: January 2021

Abstract
The β-linked N-acetyl-d-glucosamine (GlcNAc) is a posttranslational modification of serine and threonine residues catalyzed by the enzyme O-GlcNAc transferase (OGT). Increased OGT expression is a feature of most human cancers and inhibition of OGT decreases cancer cell proliferation. Antiproliferative effects are attributed to posttranslational modifications of known regulators of cancer cell proliferation, such as MYC, FOXM1, and EZH2. In general, OGT amplifies cell-specific phenotype, for example, OGT overexpression enhances reprogramming efficiency of mouse embryonic fibroblasts into stem cells. Genome-wide screens suggest that certain cancers are particularly dependent on OGT, and understanding these addictions is important when considering OGT as a target for cancer therapy. The O-GlcNAc modification is involved in most cellular processes, which raises concerns of on-target undesirable effects of OGT-targeting therapy. Yet, emerging evidence suggest that, much like proteasome inhibitors, specific compounds targeting OGT elicit selective antiproliferative effects in cancer cells, and can prime malignant cells to other treatments. It is, therefore, essential to gain mechanistic insights on substrate specificity for OGT, develop reagents to more specifically enrich for O-GlcNAc–modified proteins, identify O-GlcNAc “readers,” and develop OGT small-molecule inhibitors. Here, we review the relevance of OGT in cancer progression and the potential targeting of this metabolic enzyme as a putative oncogene.
Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN
Authors: Thurston Rebecca C. , Aslanidou Vlachos Helen E. , Derby Carol A. , Jackson Elizabeth A. , Brooks Maria Mori , Matthews Karen A. , Harlow Sioban , Joffe Hadine , El Khoudary Samar R. 
Published: January 2021

Background
Cardiovascular disease (CVD) in women has unique features, including associations with reproductive factors that are incompletely understood. Vasomotor symptoms (VMS), the classic menopausal symptom, are linked to CVD risk factors and subclinical CVD. Evidence linking VMS to CVD events is limited. We tested whether frequent and/or persistent VMS were associated with increased risk for fatal and nonfatal CVD events in SWAN (Study of Women’s Health Across the Nation).

Methods and Results

A total of 3083 women, aged 42 to 52 years at baseline, underwent up to 16 in‐person visits over 22 years. Assessments included questionnaires on VMS frequency (0, 1–5, or ≥6 days/2 weeks), physical measures, phlebotomy, and reported CVD events (myocardial infarction, stroke, heart failure, and revascularization). A subset of events was adjudicated via medical record. Death certificates were obtained. Relationships between baseline VMS or persistent VMS over the follow‐up (proportion of visits with frequent VMS) with combined incident nonfatal and fatal CVD were tested in Cox proportional hazards models adjusted for demographics, medication use, and CVD risk factors. Participants experienced 231 CVD events over the follow‐up. Women with frequent baseline VMS had an elevated risk of subsequent CVD events (relative to no VMS; ≥6 days: hazard ratio [HR] [95% CI], 1.51 [1.05–2.17],
P
=0.03; 1–5 days: HR [95% CI], 1.02 [0.75–1.39],
P
=0.89, multivariable). Women with frequent VMS that persisted over time also had an increased CVD event risk (>33% versus ≤33% of visits: HR [95% CI], 1.77 [1.33–2.35],
P
<0.0001, multivariable).

Conclusions
Frequent and persistent VMS were associated with increased risk of later CVD events. VMS may represent a novel female‐specific CVD risk factor.
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke
Authors: Zhong Chongke , Lu Zian , Che Bizhong , Qian Sifan , Zheng Xiaowei , Wang Aili , Bu Xiaoqing , Zhang Jintao , Ju Zhong , Xu Tan , Zhang Yonghong 
Published: January 2021

Background and Purpose:
Choline metabolism was suggested to play pathophysiological roles in nervous system and atherosclerosis development. However, little is known about the impacts of choline pathway nutrients and metabolites on poststroke cognitive impairment. We aimed to prospectively investigate the relationships between circulating choline, betaine, and trimethylamine N-oxide with cognitive impairment among acute ischemic stroke patients.

Methods:
We derived data from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). Plasma choline, betaine, and trimethylamine N-oxide concentrations at baseline were measured in 617 participants. Cognitive impairment was evaluated using the Mini-Mental State Examination and the Montreal Cognitive Assessment. Reclassification and calibration of models with choline-related biomarkers were evaluated.

Results:
Plasma choline and betaine were inversely associated with cognitive impairment. Compared with the lowest tertile, adjusted odds ratios of Mini-Mental State Examination–defined cognitive impairment for participants in the highest tertiles of choline and betaine were 0.59 (95% CI, 0.39–0.90) and 0.60 (95% CI, 0.39–0.92), respectively. In addition, both choline and betaine offered incremental predictive ability over the basic model with established risk factors, shown by increase in net reclassification improvement and integrated discrimination improvement. There were similar significant relationships between choline and betaine with cognitive impairment as defined by the Montreal Cognitive Assessment. However, plasma trimethylamine N-oxide was only associated with cognitive impairment evaluated using the Mini-Mental State Examination; the adjusted odds ratio was 1.33 (95% CI, 1.04–1.72) for each 1-SD increment of trimethylamine N-oxide.

Conclusions:
Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment.
Tracing the context in disciplinary classifications: A bibliometric
pairwise comparison of five classifications of journals in the social sciences
and humanities
Authors: Sīle Linda , Guns Raf , Vandermoere Frédéric , Sivertsen Gunnar , Engels Tim C. E. 
Published: January 2021

Abstract
Despite the centrality of disciplinary classifications in bibliometric analyses, it is not well known how the choice of disciplinary classification influences bibliometric representations of research in the social sciences and humanities (SSH). This is especially crucial when using data from national databases. Therefore, we examine the differences in the disciplinary profile of an article along with the absolute and relative number of articles across disciplines using five disciplinary classifications for journals. We use data on journal articles (2006–2015) from the national bibliographic databases VABB-SHW in Flanders (Belgium) and Cristin in Norway. Our study is based on pairwise comparisons of the local classifications used in these databases, the Web of Science subject categories, the Science-Metrix, and the ERIH PLUS journal classifications. For comparability, all classifications are mapped to the OECD Fields of Research and Development classification. The findings show that the choice of disciplinary classification can lead to over- or underestimation of the absolute number of publications per discipline. In contrast, if the focus is on the relative numbers, the choice of classification has practically no influence. These findings facilitate an informed choice of a disciplinary classification for journals in SSH when using data from national databases.
Playing the Man in the Book of Ruth: Reshaping the Masculine Ideal
Authors: Purcell Richard Anthony 
Published: January 2021

Abstract
Many scholars have productively analyzed the book of Ruth to explore gender roles and norms. Few studies, though, have brought masculinity theory to bear on the book of Ruth, and those that have primarily focus on the character of Boaz. However, other characters ‘play the man’ in this narrative, notably Ruth herself. Though Boaz is labeled as an אישׁ גבור חיל, Ruth often better performs the masculine ideal represented by this label. She enters dangerous situations to protect and provide for Naomi. Moreover, Ruth initiates and manipulates sexual contact in order to produce progeny. The narrative presents the characters of Ruth, Boaz, and, at times, Yhwh performing masculine roles with varying levels of success. This essay contends that the book takes up previously assumed norms of masculinity and reshapes them in light of a changing socio-political context.
The “Foreigner” and the Eunuch: The Politics of Belonging in Isaiah 56:1–8
Authors: Southwood Katherine E. 
Published: January 2021

Abstract
One important theme that has emerged recently in research concerning exile, migration, and return-migration is the concept of “belonging”, a concept that is quickly destabilising the emphasis on identity. This article will demonstrate the heuristic significance of research concerning belonging for Biblical scholars, focusing on the negative stereotypical identity labels, “the foreigner” and “the eunuch” in Isaiah 56:1–8. It will emphasise the crucial importance of using clear and differentiated analytical language and will illustrate how doing so enables us to perceive new nuances and shades of meaning in the Biblical text. We will emphasise the importance of elective attachment in Isaiah 56:1–8 and will emphasise the significance of recognising that identity labels such as “foreigner” are constructed and unstable. The article surveys material concerning belonging and demonstrates its significance for rethinking and reframing the polemic against ethnic entitlement and exclusionary language.
Effect of temperature on subclinical infection by Batrachochytrium dendrobatidis in three species of plethodontid salamanders
Authors: Mendoza-Almeralla Cinthya , Suazo-Ortuño Ireri , Parra-Olea Gabriela , Suzán Gerardo 
Published: January 2021

Abstract
We assessed the effect of temperature on subclinical Batrachochytrium dendrobatidis (Bd) infection in three species of plethodontids. Collected individuals were tested for Bd in the field during the dry and rainy season and randomly assigned to 15° and 18°C treatments for 30 days. We collected 129 salamanders, of these nine individuals tested positive for Bd in the field. At the two temperature trials, 12 individuals that were Bd-negative in the field, tested positive for Bd. Near the end of the temperature trials, 18 of 21 Bd-positive individuals tested negative for Bd. Three individuals that were Bd positive in the field and assigned to the 18°C trial died during the experiment. Our results suggest that at 15°C the most of plethodontids present subclinical infection, whereas at higher temperatures, Bd infection can increase to detectable levels. The processes underlying plethodontids’s recovery from Bd infection warrants further study.
No Sense in Saying ‘There is No Sense Organ for Time’
Authors: Singhal Ishan 
Published: January 2021

Abstract
This paper explores the use of perhaps the most ubiquitous phrase in time perception literature, i.e., ‘there is no sense organ for time’. I argue here that its usage often highlights several misguided notions about how we perceive time and thus creates a problem in studying it. In this commentary three such underlying notions are discussed which are often drawn as conclusions from the lack of a sensory system to perceive time. These are that time is generated or created separately by the brain, that time perception is different from other kinds of perception and that the study of time is hampered by the lack of a dedicated sense organ. These notions are discussed and argued against. It is claimed that a sense organ for time is not possible, nor does this exclude time from our percepts in general. Moreover, rather than creating a problem, a lack of a sense organ for time offers an opportunity to theorize about our experiences across perceptual modalities and cognitive mechanisms. I conclude by suggesting an end to using this phrase and instead seeing mental time as existing across our experiences.
Global Surface Temperature Response to 11-Yr Solar Cycle Forcing Consistent with General Circulation Model Results
Authors: Amdur T. , Stine A. R. , Huybers P. 
Published: January 2021

ABSTRACTThe 11-yr solar cycle is associated with a roughly 1 W m−2 trough-to-peak variation in total solar irradiance and is expected to produce a global temperature response. The sensitivity of this response is, however, contentious. Empirical best estimates of global surface temperature sensitivity to solar forcing range from 0.08 to 0.18 K (W m−2)−1. In comparison, best estimates from general circulation models forced by solar variability range between 0.03 and 0.07 K (W m−2)−1, prompting speculation that physical mechanisms not included in general circulation models may amplify responses to solar variability. Using a lagged multiple linear regression method, we find a sensitivity of global-average surface temperature ranging between 0.02 and 0.09 K (W m−2)−1, depending on which predictor and temperature datasets are used. On the basis of likelihood maximization, we give a best estimate of the sensitivity to solar variability of 0.05 K (W m−2)−1 (0.03–0.09 K; 95% confidence interval). Furthermore, through updating a widely used compositing approach to incorporate recent observations, we revise prior global temperature sensitivity best estimates of 0.12–0.18 K (W m−2)−1 downward to 0.07–0.10 K (W m−2)−1. The finding of a most likely global temperature response of 0.05 K (W m−2)−1 supports a relatively modest role for solar cycle variability in driving global surface temperature variations over the twentieth century and removes the need to invoke processes that amplify the response relative to that exhibited in general circulation models.