bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Pan-Cancer Analysis on CBX3 as a Prognostic and Immunological Biomarker
Authors: Niu Hongjuan , Chen Peiqiong , Fan Lu , Sun Boyu 
Published: September 2021

Abstract
Background: Increased evidence supports the relationship between chromobox protein homolog 3 (CBX3) and tumorigenesis of some cancers. However, the role of CBX3 in pan-cancers remains poorly defined. In the research, we aimed to investigate the prognostic value and the immunological functions of CBX3. Results: We explored the potential oncogenic roles of CBX3 in mRNA and protein levels based on the diverse databases, including the expression, the correlation with prognosis, tumor microenvironment (TME), DNA methylation, protein phosphorylation and enrichment analysis across all TCGA tumors. The results show that CBX3 is overexpressed in multiple cancers, and significant correlations exist between high expression and adverse prognosis in most tumor patients. We observed an enhanced phosphorylation level in uterine corpus endometrial carcinoma, colon cancer and lung adenocarcinoma. A distinct relationship was also found between CBX3 expression and TME, including immune infiltration of tumor-infiltrating lymphocytes (TILs) and cancer-associated fibroblasts (CAFs), immune score or matrix score, immune checkpoints. The correlative transcription factors and miRNAs of CBX3-binding hub genes were analyzed to investigate the molecular mechanism. Moreover, alcoholism and alteration of DNA cellular biology may be involved in the functional mechanisms of CBX3. Conclusion: The first pan-cancer study offers a relatively comprehensive cognition on the oncogenic roles of CBX3 as a prognostic and immunological marker in various malignant tumors.
A Meta-Analysis of randomized controlled trials: Efficiency and safety of ondansetron in preventing post-anesthesia shivering during cesarean section
Authors: Zheng Guanghao , Liu Jianpin , Zhang Jieyu , Cao Fei 
Published: September 2021

Abstract
Objective Although ondansetron was considered to prevent post-anesthesia shivering during cesarean section, its efficiency remained controversial. Our review was conducted to estimate the efficiency and safety of ondansetron in preventing post-anesthesia shivering during cesarean section. Methods: The literature were searched from their inception to October 2020 without restriction of language. All randomized controlled trials investigating the efficacy of ondansetron versus placebo in preventing shivering during cesarean section under neuraxial anesthesia were included. The meta-analysis was conducted using Stata software. Results: Eleven randomized controlled studies with a total of 748 individuals were finally included in our meta-analysis. Our results manifested that intravenous ondansetron compared with intravenous placebo significantly reduced the incidence of PAS (RR: 0.53, 95% CI: 0.14 to 0.68). Subgroup analysis according to doses of ondansetron indicated that the efficacy of 4 mg doses of ondansetron(RR: 0.37, 95% CI: 0.21 to 0.64) is equivalent to that of 8 mg doses of ondansetron(RR: 0.61, 95% CI: 0.47 to 0.81) in preventing PAS. In addition, the intravenous ondansetron led to a lower incidence of hypotension than intravenous placebo(OR: 0.47, 95% CI: 0.32 to 0.70). We could not demonstrate differences in the incidence of bradycardia between intravenous ondansetron and intravenous placebo. Conclusion: Our results found that intravenous ondansetron was effective in preventing shivering during cesarean section under neuraxial anesthesia, and had an advantage in reducing the incidence of hypotension compared with intravenous placebo.
Effects of Hypertensive Disorders of Pregnancy On The Mortality and Complications in Very Low Birth Weight Neonates
Authors: Zhang Baoquan , Chen Xiujuan , Yang Changyi , Shi Huiying , Xiu Wenlong , Dai Yue 
Published: September 2021

Abstract
Purpose

This study was designed to investigate the effects of hypertensive disorders of pregnancy (HDP) on the mortality and complications in very low birth weight neonates.
Methods

Premature infants at a gestational age of < 37 weeks with a birth weight of < 1,500g were included in this retrospective analysis. Gestational age-matched pregnant women with normal blood pressure giving birth to a very low birth weight neonate served as normal control. HDP neonates were divided into three subgroups based on the disease severity, including gestational hypertension, pre-eclampsia and eclampsia. Then we compared the incidence of complications among three subgroups. We also analyzed the relationship between the subgroups and the neonatal prognosis.
Results

The incidence of fetal distress, small for gestational age (SGA), mechanical ventilation, neonatal respiratory distress syndrome (RDS), neonatal necrotizing enterocolitis (NEC, ≥ 2 stage), and mortality in HDP group were significantly higher than those of the control. The 1 min Apgar score in HDP group was significantly lower than that of the normal control (P < 0.05). There were significant differences in fetal distress, 1 min Apgar score, mechanical ventilation, RDS and NEC (≥ 2 stage) among HDP, pre-eclampsia and eclampsia subgroups (P < 0.05). Multivariate regression analysis indicated that pre-eclampsia was an independent risk factor for SGA (OR = 4.123, 95%CI: 2.783–6.109) and NEC (OR = 2.493, 95%CI: 1.161–5.351). Eclampsia was a risk factor for SGA (OR = 3.804, 95%CI: 1.239–11.681) and NEC (OR = 7.264, 95%CI: 1.771–29.797).
Conclusions

HDP may affect the prognosis of very low birth weight neonates. Pre-eclampsia and eclampsia were risk factors for SGA and NEC.
Biosynthesis of Zinc Oxide (ZnO) Using Culture Biomass of Aspergillus Niger :The Influence of pH On Textile Morphology And Antimicrobial Activity
Authors: Rilda Yetria , Rinaldi Rifki , Syukri Syukri , Armaini Armaini , Refinel Refinel , Agustien Anthoni , Pardi Hilfi 
Published: September 2021

Abstract
The biosynthesis of zinc oxide (ZnO) is performed through enzymatic mechanisms, by controlling the particle size and morphology of the compound using the sol-gel method. Furthermore, this method utilizes stabilizer obtained from the cell biomass of Aspergillus niger bacteria, in order to yield homogeneous and consistent products, which corresponds with the XRD outcome that exhibits good crystallinity. The evaluation of functional, morphological, and antibacterial activities was carried out at pH 6.0-13.0, as the prepared samples were characterized by FT-IR. The analysis showed the interaction of hydroxyl groups, aromatic rings, as well as N-H and O-Zn-O compounds at a wavenumber of 401-584 cm−1. The XRD and SEM characterizations showed that the structure and crystal phase of ZnO were hexagonal wurtzite at dimensions of 36.2 - 45.4 nm. The differences in pH also influenced the dimensions, morphology, and antimicrobial activity. ZnO with pH of 8.0 was characterized by FESEM-EDAX, based on the analysis of morphological uniformity. This characterization obtained rod and cube structures, with atomic ratios of Zn = 61.5% and O = 38.5%. The UV-DRS spectrum showed that the optical band gap was not significantly influenced by the pH of the reactant solution, with a value of Eg = 3.00–3.11 eV. The differences in morphology further distinguished anti-bacterial properties on textile fibres, through the use of the Gram-negative and positive bacteria (Pseudomonas aeruginosa and Staphylococcus aureus), with inhibition zones of 17-21 mm and 21-25 mm, respectively. Therefore, ZnO is classified as a very strong antibacterial material compared to amoxicillin, with an inhibition zone of 13.6 mm.
Enhanced oil removal from a real polymer production plant by cellulose nanocrystals - Serine incorporated polyethersulfone ultrafiltration membrane
Authors: Asadi Azar , Gholami Foad , Zinatizadeh Ali Akbar 
Published: September 2021

Abstract
As discharging oily wastewater from industries to the environment is a potential threat for the aquatic ecosystem, in this research oil removal from a real case of Kermanshah polymer production plant wastewater was investigated. The focus of this study was on improving the oil rejection performance of polyethersulfone (PES) ultrafiltration membrane due to adding cellulose nanocrystals (CNC) and modified CNC with Serine amino acid (CNC-Ser) in PES mix matrix. From the results, the membranes embedded with CNC-Ser showed better performance in terms of water flux, flux recovery ratio and oil rejection (higher than 97%) compared to the modified membranes with CNC. The lowest water contact angle (41.370), the smoother surface and higher negative surface potential (-24 mv) was achieved for the optimum loading of CNC-Ser. Besides, long-term performance of the membranes with optimum loading of CNC and CNC-Ser were compared in both dead-end and cross-flow set-ups.
Malaria Prevalence in Asymptomatic and Symptomatic Children Living in Rural, Semi-Urban and Urban Areas in Eastern Gabon.
Authors: Kouna Lady Charlène , LIABAGUI Sandrine Lydie OYEGUE , VOUMBO-Matoumona Dominique Fatima , LEKANA-DOUKI Jean Bernard 
Published: September 2021

Abstract
Background
Malaria remains a major public health issue in the world despite a decline in the disease burden. However, though symptomatic malaria is diagnosed and treated, asymptomatic infections remain poorly known and support transmission. This study assessed the prevalence of symptomatic and asymptomatic plasmodial infections in three areas in Gabon to monitor and evaluate the impact of malaria.
Methods
A cross-sectional study was conducted at the Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF). Febrile children and without fever, aged 6 months to 15 years from three localities (Franceville, Makokou, Lastoursville) in south-eastern Gabon were included in this study. The Plasmodium Spp infection was determined by microscopy and/or rapid diagnostic tests (RDT) followed by PCR according to the Snounou method. The data were recorded in Excel, and the statistical analyzes were performed using the software R version R 64x 3.5.0.
Results
Two thousand three hundred and eighty-one (2381) children were screened and included in this analysis. The mean age was significantly higher in asymptomatic children compared to symptomatic children. Hematological parameters varied significantly according to regions and clinical signs. The overall prevalence of Plasmodium infection was 40% (952/2381). In the urban area (Franceville) the prevalence of plasmodial infection was not significantly different between symptomatic and asymptomatic children. In contrast, a high prevalence of symptomatic plasmodial infection was found in infected children in rural and semi-rural areas. Among the three plasmodial species (Plasmodium falciparum, Plasmodium malariae, Plasmodium ovale) identified, Plasmodium falciparum was the most widespread, and its prevalence was not significantly different between symptomatic and asymptomatic children in the three localities. In rural and semi-rural areas, a higher or lower prevalence of Plasmodium malariae was demonstrated in asymptomatic children.
Conclusion
This study showed that the prevalence of plasmodial infection varied according to the regions and clinical signs. The main species was Plasmodium falciparum, but in asymptomatic children the prevalence of Plasmodium malariae was high in rural areas. To help fight malaria more effectively asymptomatic infections should be taken into account and treated.
Optical Navigation-Related Factors Interfering With The Accuracy of Robot-Assisted Surgery
Authors: Tian Wei , Shi Zhan , Li Zuchang , Fan Mingxing , Wang Qilong , Liu Yajun , Liu Bo , He Da , Zhao Jingwei , Lang Zhao , Ma Sai 
Published: September 2021

Abstract
Objective To explore navigation-related factors interfering with accuracy of robot-assisted surgery. Methods We made a measurement model to test the accuracy of the TianJi Robot system when performing the stimulated screw placement procedure. The three-coordinate machine was used to measure the deviation between the actual position and the planned position. We designed corresponding experiments to explore the effects of different navigation-related factors on the screw placement accuracy. The deviations were measured at different distance (ranging from 1.2 m to 2.2 m) between the navigation optical stereo camera and the tracker and each distance was measured 50 times. The distance between the optical camera and the patient tracker was set at 1.4 m and the deviations were measured at different angles between the camera and the robot tracker, each angle was measured more than 25 times. Data was donated with mean and standard deviation. The line charts were employed to describe the changes of deviations over one clinical factor including distance and angle. Results Within the available scope of navigation optical system (1.2 m-2.2 m), the deviation increased with the distance (χ2=479.107, P<0.001). The robotic system accuracy was high and stable (mean deviation 0.332 mm ± 0.067 mm) when the relative angle between the optical camera and the tracker less than 40 degrees. Conclusions Accuracy of robot system was affected by the relative distance and angle between the optical camera and the tracker. When placing and adjusting the optical tracking devices, surgeons should set the relative distance between the optical camera and the patient tracker as 1.4 m- 1.5 m and the relative angle less than 40 degrees.
The Impact of a Peer Social Support Network From the Perspective of Women With Fibromyalgia. A Qualitative Study
Authors: Reig-Garcia Glòria , Bosch-Farré Cristina , Suñer-Soler Rosa , Juvinyà-Canal Dolors , Pla-Vila Núria , Boix-Roqueta Esther , Noell-Boix Rosa , Mantas-Jiménez Susana 
Published: September 2021

Abstract
Background: Fibromyalgia is a chronic and complex disease whose management by patients requires a high level of commitment. Patient empowerment therefore represents an important milestone in chronic disease treatment and control. We explored the impact of a peer social support network from the perspective of women with fibromyalgia.Methods: A generic qualitative design was proposed for the study, for which women who had been diagnosed with fibromyalgia were purposefully selected. Six semi-structured interviews were conducted and the collected data were thematically analysed.Results: Three key themes emerged regarding the peer social support network: (1) empowerment (it facilitated acceptance of the diagnosis and was a source of information); (2) effects on wellbeing and quality of life (it attenuated stigma, improved physical wellbeing, provided emotional support and was a socialization medium); and (3) valuable aspects (it transmitted feelings of being understood and listened to and it increased personal feelings of satisfaction).Conclusions: A peer social support network for women with fibromyalgia exerts positive effects on their physical, mental, and social wellbeing and empowers them to better manage their disease. Healthcare for women with fibromyalgia should include strategies that connect them through peer social support networks.
The effects of ethyl lauroyl arginine hydrochloride (ELAH) in nasal spray formula on SARS-Cov-2
Authors: Thacore Harshad R. , Gaffar Abdul , Yun Seiyoung , Chenine Agnes L. , Ferrari Maria . G. 
Published: September 2021

Abstract
SARS-CoV-2 and coronaviruses, enveloped RNA viruses, are major causes of acute human respiratory diseases. The aim of the study was to investigate the broad-spectrum antiviral effects of ethyl lauroyl arginine hydrochloride (ELAH) in in vitro and in vivo assays. Cell-based assays found that the pseudovirus VSV-SARS-CoV-2 was inhibited with an EC50 of 15 micrograms/ml, with complete inhibition achieved at 110 micrograms/ml. The effects were comparable to those observed with anti-SARS-CoV-2 antibody neutralization assays against VSV-SARS-CoV-2. Intranasal administration of the Wuhan strain of SARS-CoV-2 treated in vitro with ELAH inhibited the disease symptoms caused by the virus in a Syrian hamster model compared to that caused by the same dose of virus treated in vitro with medium alone. Subgenomic RNA and total RNA viral load were concomitantly reduced in the treated animals compared with the control group. In cell-based studies, pretreatment of susceptible cells with 1–10 micrograms/ml ELAH inhibited the attachment of the virus to the cells, as measured by cytopathic and high-resolution scanning electron microscopy (SEM) effects, suggesting that the primary mode of ELAH action was due to preventing the attachment of the virus to the cells. Collectively, the data suggest that ELAH could be a promising agent for the prevention of SARS infection through nasopharyngeal surfaces.
Experiences of Health Providers and patients in COVID‑19: A SWOT analysis
Authors: kheirkhah Aliasghar , Movahed Ehsan , gheyabi Fereshte , Farsani Fatemeh kave , Rigabadi Fatemeh 
Published: September 2021

Abstract
Background: Health providers and patients face many problems in preventing and controlling COVID-19 in the family and the health system.Aim: The aim of the present study was to explore experiences of health providers and patients in COVID‑19.Methods: directional qualitative content analysis was applied and 15 participants, including 10 patients with COVID-19 and 5 health providers. Data were collected using semi-structured interviews and analyzed by Lundman and Graneheim qualitative content analysis methods. The MAXQDA10 software was used to manage qualitative data analysis.Results: During the data analysis, "strengths", "weaknesses", "opportunities", and "threats" were defined in terms of categories. The " Benefits and Barriers " was determined as the main theme.Conclusion: Community members and policymakers should support and reinforce the positive experiences of patients and health providers and the health system and families need to be more prepared for the crisis.
Managing Fuels, Tree, and Stand Growth Using Prescribed Fire and Alternatives in Young Mixed Conifer Stands
Authors: Russell Kane Winslow , York Robert A. 
Published: September 2021

Abstract
Background

In the wake of increasingly frequent and severe wildfires in California, artificial regeneration and density management facilitate prompt reforestation and the rapid growth of large, fire-resistant trees. Young plantations are particularly prone to high-severity wildfire effects, suggesting the implementation of fuel reduction treatments in the early stages of stand development. The extent to which density management (i.e., thinning) and fuels management (i.e., prescribed fire) can work together is uncertain given their potentially conflicting effects on tree and stand level growth. We investigated how four different treatments – mastication, mastication plus herbicide, two prescribed burns, and mastication plus two burns – affected individual and stand-level growth versus fuel loads in mixed-conifer plantations during young stand development in the north-central Sierra Nevada, California, USA.
Results

The mastication plus herbicide treatment maximized individual tree growth, especially for white fir and incense-cedar, but fuel loads doubled after five years without the use of fire. The mastication only treatment resulted in a 151% increase in fuel loads over the same period, and individual tree growth was comparable to the burn only and mastication plus burn treatments. The burn only treatment greatly decreased fuel loads but also resulted in low relative stand growth. The mastication plus burn treatment prevented fuel accumulation and generally did not slow down individual tree growth. In addition, stand growth occurred at a rate similar to that of the mastication plus herbicide treatment.
Conclusions

Mastication followed by repeated prescribed burning could be a viable management strategy to reduce wildfire hazard without sacrificing growth in young mixed-conifer stands that are entering a vulnerable stage of fire risk. Mastication in combination with herbicide may grow trees to a large, fire-resistant size more quickly, but does not address fuel buildup. The use of fire alone can effectively reduce fuels while not substantially impacting individual tree growth, but stand growth may decline relative to mastication and herbicide.
Telephone-Based Reminder To Improve Safety After Percutaneous Coronary Intervention
Authors: Chidester Jeffrey , Bennett Daniel , Mathew Chris , Denkins Tiffany , Vigen Rebecca , Addo Tayo , Das Sandeep 
Published: September 2021

Abstract
Introduction: Dual Antiplatelet Therapy (DAPT) is a class I guideline indication after Percutaneous Coronary Intervention (PCI). Our population is high-risk for low medication adherence. With a multidisciplinary team we developed a telephone-based intervention to improve DAPT adherence post-PCI. Methods: Patients undergoing PCI at our center were contacted by nursing staff via telephone at 1 week, 30 days, and 60 days post-procedure. Calls included a reminder of the importance of DAPT and elicited any patient concerns. Concerns were relayed to the team who could take appropriate action. For patients filling their medications at any pharmacies within our closed system the proportion of days covered (PDC) was calculated. These were compared to data for patients undergoing PCI in the seven months prior to program initiation. Information on interventions performed as a result of calls was also collected. Results: During the study period, 452 patients underwent PCI. Of these, 70% were contacted and 244 filled their prescription at our system pharmacies. Twelve-month median PDC was 74%, with 45% of patients having PDC >80%. There was no significant difference when compared to the group prior to the intervention, median PDC 79% and 50% of patients having PDC >80%. In 26 patients calls led to interventions, removing barriers that would have otherwise prevented continued adherence. Conclusion: A telephone-based reminder system led to directed interventions in nearly 1 in 10 patients contacted. It was not able to significantly improve PDC when compared to a contemporary sample. This highlights the difficulty in using PDC to detect barriers to adherence.
Effects of Kinesiology Taping On Sleep Quality In Participants With Cronical Low Back Pain
Authors: Yükselmiş Özkan 
Published: September 2021

Abstract
Our main aim in this study is to compare the effectiveness of conventional physical therapy in the context of sleep quality of participants with chronic low back pain and the effectiveness of kinesiology taping applied to the waist area in a very short time.40 participants (30 females, 10 males) whose age ranges ranged from 25 to 50 years were randomly divided into two groups (banding group and control group). In both groups, a home exercise program was given by applying therapeutic ultrasound for 5 minutes, TENS (Transcutaneous Electrical Nerve Stimulation) for 30 minutes and infrared for 30 minutes. In kinesiology taping groups, taping was applied to the waist region with the star technique, once for 48 hours. VAS (Visual Analog Scale) for pain, hip flexor flexibility test and hand-finger floor distance test for flexibility, Berg balance scale for balance, Beck anxiety scale for anxiety, Oswestry disability index for disability level, Tampa kinesiophobia scale for kinesiophobia, sleep quality Pittsburg sleep quality index and Nottingham life profiles were used for quality of life. Evaluations were made twice, before and after the treatment. The significance level was accepted as p <0.05.