bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence of Hepatitis C and Hepatitis B in Lesbian, Gay, Bisexual and Transgender Populations: A Systematic Review and Meta-Analysis
Authors: Moradi Ghobad , Soheili Marzieh , Rashti Roya , Dehghanbanadaki Hojat , Nouri Elham , Zakaryaei Farima , Amini Elnaz Ezzati , Baiezeedi Sheno , Ahmadi Sanaz , Moradi Yousef 
Published: November 2021

Abstract
Objectives: This study aimed to systematically review the literature on the prevalence of Hepatitis C virus (HCV) and Hepatitis B virus (HBV) infections in transgender and LGBT people and determine their pooled estimates worldwide.Methods: Databases (PubMed, Scopus, Web of Science, Embase, Ovid, Cochrane, PsycInfo) were searched from April 2000 to July 2021. The pooled, subgroup, and cumulative analyses were executed using the random-effects model in Stata 16. Results: Ten studies, including eight studies on Four transgender people and two studies on 2150 LGBTs, were included. The pooled prevalence of HCV and HBV in all transgender populations globally were 9% (95%CI: 3- 15%) and 11% (95%CI: 2- 20%), respectively. The corresponding prevalence in male-to-female transgender people were estimated as 5% (95%CI: 1- 9%) and 6% (95%CI: 3- 10%), respectively. These estimates in American transgenders were 10% (95%CI: 5- 25%) and 16% (95%CI: 8- 23%), respectively. Conclusion: This study was identified the overall prevalence of HBV and HCV infections in transgender people, which were higher than those in the general population. Thus, this group of sexual minorities was at higher risk for HBV and HCV infections, and it was necessary to develop, design, and implement a protocol for providing services related to HBV and HCV infections, such as a hepatitis B vaccination program and treatment of hepatitis C along with screening and designing appropriate interventions in transgender people.
Progesterone Inhibits LPS-Induced Oxidative Stress Through Nrf2/Keap1 Pathway in Bovine Endometrial Epithelial Cells
Authors: Cui Luying , Zhang Qi , Zhang Jiaqi , Wang Heng , Dong Junsheng , Li Jun , Qian Chen , Li Jianji 
Published: November 2021

Abstract
Background
Postpartum uterine infection can lead to endometrial inflammation and oxidative damage. Progesterone makes the animal more susceptible to uterine infection. Progesterone has been proved to play an anti-inflammatory role in inhibiting uterine innate immunity, and to reduce tissue oxidative damage. But the effect of progesterone on the oxidative damage of bovine endometrium has not been reported. The purpose of this study was to explore the effect and mechanism of progesterone (1, 3, and 5 ng/mL) on oxidative damage in primary bovine endometrial epithelial cells (BEEC) induced by lipopolysaccharide (LPS) from Escherichia coli.
Results
Compared with the LPS group, there were decreases (P < 0.05) in the levels of reactive oxygen and malondialdehyde, and increases (P < 0.05) in the activities of superoxide dismutase and catalase, and total antioxidant capacity in the cotreatment groups of progesterone and LPS. The cotreatment of LPS and P4 upregulated (P < 0.05) the mRNA abundance of antioxidant genes and the key protein levels in Nrf2/Keap1 pathway, and promoted the Nrf2 protein to enter the nucleus. The use of progesterone receptor antagonist mifepristone reversed the antioxidative effect of progesterone.
Conclusions
Progesterone protects BEEC from LPS-induced oxidative damage by activating Nrf2/Keap1 pathway through progesterone receptor.
PI3K/AKT Pathway Promotes Keloid Fibroblasts Proliferation by Enhancing Glycolysis Under Hypoxia
Authors: Wang Qifei , Yang Xin , Ma Jianxun , Xie Xiang , Sun Yimou , Chang Xu , Bi Hongsen , Xue Hongyu , Qin Zelian 
Published: November 2021

Abstract
Background

Keloids are disfiguring fibro-proliferative disorders characterized by glucose metabolism reprogramming, namely elevated glycolysis and compromised oxidative phosphorylation. Our previous study demonstrated altered glucose metabolism and enhanced phosphorylation of the PI3K/AKT pathway in keloid fibroblasts (KFb) under hypoxic conditions. However, whether the PI3K/AKT pathway influences KFb cell function by regulating glucose metabolism under hypoxic conditions remains unclear.
Results

Our findings revealed that when the PI3K/AKT pathway was inactivated with LY294002 under hypoxia, the protein expression of glycolytic enzymes GLUT1, HK2, PFKFB3, PGK1, ENO1, PKM2, and LDHA decreased under hypoxia, while the amount of mitochondria and mitochondrial membrane potential (MMP) increased, and mitochondrial ultrastructure in KFb remained unchanged. The key parameters of extracellular acidification rate (ECAR) markedly diminished, and those of oxygen consumption rate (OCR) significantly increased after inhibition of the PI3K/AKT pathway. When the PI3K/AKT pathway was suppressed, the levels of ROS and mitochondrial ROS were significantly increased. Meanwhile, cell proliferation, migration, and invasion were inhibited, and apoptosis was increased when the PI3K/AKT pathway was blocked. Additionally, cell proliferation was compromised when KFb were treated with both SC79 (an activator of the PI3K/AKT pathway) and 2-DG (an inhibitor of glycolysis), compared to the SC79 group. Moreover, a positive feedback mechanism was demonstrated in the PI3K/AKT pathway and HIF-1α.
Conclusions

Our data collectively demonstrated that the PI3K/AKT pathway promotes proliferation and inhibits apoptosis in KFb under hypoxia by regulating glycolysis, indicating that the PI3K/AKT signaling pathway could be a therapeutic target for keloids.
Comprehensive identification of protein orthologs facilitated an understanding of the phylogenomics, protein conservation and phosphorylation of Ascoviridae species
Authors: Shi Yanhua , Lin Weiping , Wang Guohui , Zhao Punan , Huang Guo-hua , Hou Dianhai 
Published: November 2021

Abstract
Analysis of orthology is important for understanding protein conservation, function and phylogenomics. This study performed a comprehensive identification of Ascoviridae orthology based on identification of 366 ascoviridae protein homologue groups and phylogenetic analysis of 34 non-single copy proteins. Our fondings revealed 90 newly annotated proteins, five new identified Ascoviridae core proteins and 14 Ascovirus core proteins. Moreover, a phylogenomic tree of 11 ascoviridae species was inferred based on the concatenation of 35 of 45 Ascoviridae ortholog groups. In combination with phosphoproteomic results and conservation estimations, 30 conserved phosphorylation sites on 17 phosphoproteins were identified from a total of 176 phosphosites on 57 phosphoproteins from Heliothis virescens ascovirus 3h (HvAV-3h), supplying potential research targets for exploration of the detailed role of these protein in the regulation of viral infection mechanisms. This study would facilitates further Ascoviridae genome annotation and comparison and other functional genomic investigations.
Analysis of Electromagnetic Force And Formability of Tube Electromagnetic Bulging Based On Convex Magnetic Field Shaper
Authors: Wu Weiye , Qiu Li , Abu-Siada A. , Wang Chenglin , Jiang Jinbo 
Published: November 2021

Abstract
In order to solve the problems of non-uniform axial deformation and thinning of wall thickness in traditional tube electromagnetic bulging, a method of tube electromagnetic bulging based on convex magnetic field shaper is proposed in this paper. The electromagnetic-structure coupling model is constructed by using COMSOL software, and the influence of convex magnetic field shaper structure on radial and axial electromagnetic force, axial deformation uniformity and wall thickness reduction is analyzed, and compared with traditional tube electromagnetic bulging. The results show that by using this method, the axial deformation uniformity is increased by 4.2 times, and the relative wall thickness is reduced by 33%. Obviously, this method of tube bulging can effectively overcome the problems existing in traditional tube electromagnetic bulging and promote the wide application of electromagnetic forming technology.
Radiologic Cervical Parameters To Determine Ligamentous Injuries in Patients With Ankylosing Spondylitis – Are They Different?
Authors: Teuber Henrik , Halvachizadeh Sascha , Muthirakalayil Melvin , Yin Luxu , Eisenkrein Harry , Hildebrand Frank , Kobbe Philipp , Sprengel Kai , Mica Ladislav , Alkadhi Hatem , Pape Hans-Christoph , Pfeifer Roman 
Published: November 2021

Abstract
Introduction: Cervical ligamentous injuries in patients with ankylosing spondylitis (AS) may be difficult to detect, even with the utilization of computed tomography (CT) scans. The purpose of this study was to investigate the influence AS has on various radiologic parameters used to detect traumatic and degenerative pathologies of the cervical spine. Methods: A matched, case-control retrospective analysis of patients with AS and controls without AS admitted at two level-1 trauma centers was performed. All patients were admitted via shock room and received a polytrauma CT. Study patients were included if they had no injury to the cervical spine. Twenty-four CT parameters of atlanto-occipital dislocation/ instability, traumatic and degenerative spondylolisthesis, basilar invagination, and prevertebral soft-tissue swelling were assessed. Study patients were matched by age and sex. Results: A total of 78 patients were included (AS group, n=39; control group, n=39). The evaluated cervical radiologic parameters were largely within normal limits and showed no significant clinical or morphologic differences between the two groups. Conclusion: In this analysis, CT measurements pertaining to various cervical pathologies were not different between patients with and without ankylosing spondylitis. Parameters to assess for atlanto-occipital dislocation/ instability, spondylolisthesis, or basilar invagination may reliably be used in patients with AS.
Finite Element Analysis and Comparative Study of 4 Kinds of Internal Fixation Systems for Anterior Cervical Discectomy and Fusion in Children
Authors: li ziyu , Zhou Jianqiang , Li Zhijun , Zhang Shaojie , wang xing , Li xiaohe 
Published: November 2021

Abstract
Background: Spinal injury in children usually occurs in the cervical spine region. Anterior fixation of lower cervical spine has been applied in the treatment of pediatric cervical spine injury and disease due to its stable and firm mechanical properties. This study performed finite element analysis and comparison of 4 different anterior cervical internal fixation systems for children, and explored more stable methods of anterior cervical internal fixation in children. Methods: A finite element model of 6-year-old children with lower cervical spine C4/5 discectomy was established, and the self-designed lower cervical spine anterior locking internal fixation system ACBLP and the children’s anterior cervical internal fixation system ACOP, ACVLP, ACSLP plate screws were fixed and loaded on the model. 27.42N•m torque load was applied to each internal fixation model under 6 working conditions of anteflexion, backward flexion, left flexion, right flexion, left rotation and right rotation, to simulate the movement of the cervical spine. The activity and stress distribution cloud diagram of each finite element model was obtained. Results: In the four internal fixation models of ACOP, ACVLP, ACSLP, and ACBLP, the mobility of C4/5 segment basically showed a decreasing relationship, and the mobility of adjacent segments increased significantly. In the Mises stress cloud diagram of the cervical spine of the four models, the vertebral body and accessories of the ACBLP model born the least stress, followed by ACSLP; The steel plate and screws in the ACVLP internal fixation model were the most stressed; The stress of the internal fixation system (plate/screw) in all models increased in the order of ACBLP, ACSLP, ACVLP, and ACOP.Conclusions: ACBLP internal fixation system had obvious advantages in anterior internal fixation of lower cervical spine in children, C4/5 had the smallest degree of movement, relative displacement was minimal, the stress on the pedicle was the least while the stress on the plate screw was relatively the smallest.
A low-cost environmentally friendly approach to isolate lignin containing micro and nanofibrillated cellulose from Eucalyptus globulus bark by steam explosion
Authors: NADER Saad , BROSSE Nicolas , KHADRAOUI Malek , FUENTEALBA Cecilia , ZIEGLER-DEVIN Isabelle , QUILÈS Fabienne , MAURET Evelyne , CHATEL Sofiane EL KIRAT 
Published: November 2021

Abstract
Micro- and Nano-Fibrillated Cellulose (MNFCs) have gained an increasing attention due to their remarkable properties but their production usually requires an intensive multi-step process. This study proposes to find a novel approach involving steam explosion for the production of lignin-containing micro- and nano-fibrillated cellulose (L-MNFCs) using Eucalyptus globulus bark as a new lignocellulosic feedstock. Eucalyptus globulus bark was first pre-treated in alkali conditions by steam explosion in alkaline conditions (200°C, 8 min) or by conventional alkaline cooking in a rotating autoclave (170°C, 60 min), refined and then grinded until the formation of gels. The chemical composition (Ionic chromatography, FTIR-ATR) of the pulps and morphology of the products (Morfi Neo, Optical and Atomic Force Microscopies (AFM), suspension turbidity) have been studied. Nanopapers were produced from lignin-containing microfibrils to investigate the mechanical properties. Results obtained showed that steam explosion produced pulps with slightly higher lignin content (≈ 9 %), containing shorter fibers (≈ 400 µm) and higher amounts of fine elements (≈ 86 %) compared to conventional alkali cooking (≈ 5 %, ≈ 560 µm and 66 %, respectively). AFM images of SteamEx L-MNFC gels showed a web-like structure containing lignin nanoparticles.
Performance of RC Cast-in-Place Buildings During The November 26, 2019 Albania Earthquake
Authors: Marinković Marko , Baballëku Markel , Isufi Brisid , Blagojević Nikola , Milićević Ivan , Brzev Svetlana 
Published: November 2021

Abstract
This paper documents performance of cast-in-place reinforced concrete (RC) buildings in the Durrës during Albania earthquake of 26th of November 2019 (MW 6.4). Both mid- and high-rise RC buildings were affected by the earthquake, experiencing structural and/or non-structural damage and even collapse in some cases. The authors performed a reconnaissance study after the earthquake and were involved in seismic assessment of buildings in the affected area. Besides the observations related to physical damage related to RC buildings, the paper also presents results of a statistical analysis of damaged RC buildings in the Durrës city. The discussion in the paper is focused on damage patterns and failure mechanisms that are relevant for the seismic response of RC structures. Most common damage pattern is related to masonry infill walls, which experienced damage and failure in some cases, and affected the performance of adjacent RC columns due to the infill/frame interaction. Taller RC framed buildings (10 storeys and higher) were expected to have RC shear walls; however, these walls were reportedly absent in the damaged buildings of this type. In some cases, masonry infill walls (instead of RC shear walls) were used in the elevator shaft areas, which resulted in inadequate seismic performance. Two case study buildings were presented in detail to illustrate seismic behaviour of cast-in-place RC buildings. The case study is based on field observations after the earthquake and a detailed seismic assessment study. Finally, relevant lessons and recommendations are presented in light of the observed performance of RC buildings.
Disparities in Fruit and Vegetable Intake at the Intersection of Gender and Education in Northern Sweden: A Cross-Sectional Study
Authors: Vogt Thomas , Gustafsson Per E 
Published: November 2021

Abstract
Background: Even though the existence of inequalities in fruit and vegetable consumption has been well established, it is not clear how it is patterned across intersections of multiple social positions and identities. This study aims to investigate disparities in fruit and vegetable intake between groups at the intersection of education and gender in northern Sweden, and to estimate the discriminatory accuracy of the intersectional groups.Methods: Cross-sectional data from the 2018 Health on Equal Terms survey conducted in four regions in northern Sweden was used (N=21,853). Four intersectional groups were created: high and low educated men, and high and low educated women. Prevalence differences corresponding to joint, referent, and excess intersectional inequalities, were estimated using linear binomial regression for three binary outcome variables: inadequate fruit and vegetable intake combined, inadequate fruit intake, and inadequate vegetable intake. The analysis was adjusted for potential confounders. The discriminatory accuracy of the intersectional groups was estimated by the area under the receiver operating characteristic curve.Results: Low educated men had the highest prevalence of inadequate intake of fruits and vegetables combined (81.4%), fruits (53.5%), and vegetables (54.2%), while high educated women had the lowest (47.7%, 28.6%, and 19.2% respectively). The joint disparities between high educated women and low educated men were both significant and substantial for all outcome variables (34.6 pp, 28.7pp, and 34.9pp respectively, adjusted). They were mostly explained by the two referent disparities for gender and education – the part of the joint disparity explained by differences in gender and education, respectively. An inconsistent direction, magnitude, and significance between outcomes was observed for the excess intersectional disparity - the part of the joint disparity not explained by either referent disparity (-5.5pp, 0.1pp, and 3.9pp respectively, adjusted). The discriminatory accuracy of the intersectional groups was moderate (0.67, 0.64, and 0.66 respectively).Conclusion: An intersectional approach can provide a more detailed view of inequalities in fruit and vegetable consumption between groups combining several social positions. The moderate discriminatory accuracy observed here suggests that interventions and policies aiming to reduce diet inequalities should not solely be targeted at certain groups, but also be universal.
Peripherally Inserted Central Catheters: Evaluation of Diluted Lipid Emulsion as Lubricant for Improved Guidewire Removal in a Neonatal Population.
Authors: Rens Matheus F.P.T. van , Paramban Ratheesh , Francia Airene L.V. , Singh Kalpana , Chandra Prem , Mahmah Mohamad Adnan , Thome Ulrich H. , Spencer Timothy R. 
Published: November 2021

Abstract
Background: Medical management of neonates is often predicated upon safe and reliable vascular access which may be related to physiological monitoring, medical treatment, supportive therapy and diagnostic or procedural purposes. For this, peripherally inserted central catheters (PICCs) are deemed safe to provide vascular access and infusion related therapy in the neonatal intensive care setting. Purpose: PICCs are associated with a reduced incidence of complications compared to short peripheral catheters. Despite a reduced complication rate, the impact for the patient has to be considered severe. Difficult PICC guidewire removal during the insertion procedure is known to cause catheter damage, resulting in leakage or breakage of the catheter itself. The aim of this study was to assess and compare the incidence of therapy failure related to the use of preflush fluids (normal saline (NSS) versus diluted lipid solution(DLS)) used before PICC guidewire removal. Method and Setting: This was a retrospective observational study and performed on the Neonatal Intensive Care Unit (NICU) of the Women’s Wellness and Research Centre, Hamad Medical Corporation, Qatar. The single site study included 507 neonates who required intravenous therapy. Results: The results show that the use of a diluted lipid preflush resulted in significantly less therapy failures, compared with the control group. This remains significant after adjusting for day of insertion, gestational age, birth weight and catheter type.Conclusion: DLS preflush demonstrated a benefit over the use of a NSS preflush to enhance PICC guidewire removal in patients admitted to the NICU. The risk for the development of maintenance-related complications leading to premature removal of the device, decreased significantly if the preflush DLS was used. During the study period no known complications related to the used lipid solution were identified. Implications for Practice and Research: This study is the first of its kind ever published in international literature and supports the enhancement of guidewire removal by using a diluted lipid preflush. When the requirement for vascular access is most pertinent, using a diluted lipid preflush is a safe and effective method to remove the guidewire in order to facilitate long-term vascular access amongst the neonatal population.
Cerebrospinal Fluid Profile of Lipid Mediators In Alzheimer’s Disease
Authors: Do Khanh Van , Hjorth Erik , Wang Ying , Jun Bokkyoo , Kautzmann Marie-Audrey I. , Eriksdotter Maria , Schultzberg Marianne , Bazan Nicolas G 
Published: November 2021

Abstract
Background: Alzheimer's disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting from insufficient resolution is involved in the pathogenesis of AD and is associated with cognitive impairment. Specialized pro-resolving lipid mediators (LMs) that promote the resolution of inflammation may be valuable markers in AD diagnosis and as therapeutic targets.Methods: Liquid chromatography-tandem mass spectrometry was used to analyze pro-resolving and pro-inflammatory LMs in cerebrospinal fluid (CSF) from patients with cognitive impairment ranging from subjective impairment to a diagnosis of AD, and correlated to cognition, CSF tau and β-amyloid (Aβ), and an inflammation biomarker (YKL-40). Results: RvD4, neuroprotectin D1, MaR1, and RvE4 were lower in AD and/or MCI compared to SCI. The pro-inflammatory LTB4 and 15-HETE were higher in AD and MCI, respectively, while PGD2 and PGE2 were decreased in AD, compared to SCI. RvD4 was also negatively correlated to AD tangle biomarkers. Many differences were dependent on gender.Conclusion: In this exploratory study of the lipidome in CSF of AD, MCI and SCI, the results indicate a gender-dependent shift in the LM profile from pro-resolving to pro-inflammatory in progression to AD, suggesting that it may be of use as a biomarker when followed by confirmation by replication studies.