bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Challenge of Integrating eHealth Into Health Care: Systematic Literature Review of the Donabedian Model of Structure, Process, and Outcome
Authors: Tossaint-Schoenmakers Rosian , Versluis Anke , Chavannes Niels , Talboom-Kamp Esther , Kasteleyn Marise 
Published: April 2021

Background
Health care organizations are increasingly working with eHealth. However, the integration of eHealth into regular health care is challenging. It requires organizations to change the way they work and their structure and care processes to be adapted to ensure that eHealth supports the attainment of the desired outcomes.

Objective
The aims of this study are to investigate whether there are identifiable indicators in the structure, process, and outcome categories that are related to the successful integration of eHealth in regular health care, as well as to investigate which indicators of structure and process are related to outcome indicators.

Methods
A systematic literature review was conducted using the Donabedian Structure-Process-Outcome (SPO) framework to identify indicators that are related to the integration of eHealth into health care organizations. Data extraction sheets were designed to provide an overview of the study characteristics, eHealth characteristics, and indicators. The extracted indicators were organized into themes and subthemes of the structure, process, and outcome categories.

Results
Eleven studies were included, covering a variety of study designs, diseases, and eHealth tools. All studies identified structure, process, and outcome indicators that were potentially related to the integration of eHealth. The number of indicators found in the structure, process, and outcome categories was 175, 84, and 88, respectively. The themes with the most-noted indicators and their mutual interaction were inner setting (51 indicators, 16 interactions), care receiver (40 indicators, 11 interactions), and technology (38 indicators, 12 interactions)—all within the structure category; health care actions (38 indicators, 15 interactions) within the process category; and efficiency (30 indicators, 15 interactions) within the outcome category. In-depth examination identified four most-reported indicators, namely “deployment of human resources” (n=11), in the inner setting theme within the structure category; “ease of use” (n=16) and “technical issue” (n=10), both in the technology theme within the structure category; and “health logistics” (n=26), in the efficiency theme within the outcome category.

Conclusions
Three principles are important for the successful integration of eHealth into health care. First, the role of the care receiver needs to be incorporated into the organizational structure and daily care process. Second, the technology must be well attuned to the organizational structure and daily care process. Third, the deployment of human resources to the daily care processes needs to be aligned with the desired end results. Not adhering to these points could negatively affect the organization, daily process, or the end results.
Effects of Myo-inositol Hexaphosphate (SNF472) on Bone Mineral Density in Patients Receiving Hemodialysis
Authors: Bushinsky David A. , Raggi Paolo , Bover Jordi , Ketteler Markus , Bellasi Antonio , Rodriguez Mariano , Sinha Smeeta , Garg Rekha , Perelló Joan , Gold Alex , Chertow Glenn M. ,   on behalf of the CaLIPSO Investigators*
Published: April 2021

Background and objectives
In the CaLIPSO study, intravenous administration of SNF472 (300 or 600 mg) during hemodialysis significantly attenuated progression of coronary artery and aortic valve calcification. SNF472 selectively inhibits formation of hydroxyapatite, the final step in cardiovascular calcification. Because bone mineral is predominantly hydroxyapatite, we assessed changes in bone mineral density in CaLIPSO.

Design, setting, participants, & measurements
Patients with coronary artery calcification at screening (Agatston score of 100–3500 U) were randomized 1:1:1 to receive placebo, 300 mg SNF472, or 600 mg SNF472 as an intravenous infusion during hemodialysis three times weekly for 52 weeks. Dual-energy x-ray absorptiometry (DXA) scans were obtained at baseline (screening) and end of treatment, and between-group changes from baseline were compared using analysis of covariance.

Results
Among 274 randomized patients, 202 had evaluable DXA scans at baseline and postrandomization (the DXA-modified intention-to-treat population). Mean (95% confidence interval) changes in total-hip bone mineral density from baseline to week 52 were −1.5% (−2.7% to −0.3%), −1.5% (−2.7% to −0.4%), and −2.5% (−3.8% to −1.2%) in the placebo, 300 mg SNF472, and 600 mg SNF472 groups, respectively. Mean (95% confidence interval) changes in femoral-neck bone mineral density from baseline to week 52 were −0.3% (−1.6% to 1.0%), −1.0% (−2.3% to 0.2%), and −2.6% (−4.0% to −1.3%), respectively. Regression analyses showed no correlation between change in coronary artery calcium volume and change in bone mineral density at either location. Changes in serum alkaline phosphatase, calcium, magnesium, phosphate, and intact parathyroid hormone levels were similar across treatment groups. Clinical fracture events were reported for four of 90, three of 92, and six of 91 patients in the placebo, 300 mg SNF472, and 600 mg SNF472 groups, respectively.

Conclusions
Bone mineral density decreased modestly in all groups over 1 year. In the 600 mg SNF472 group, the reduction appeared more pronounced. Reported fractures were infrequent in all groups.

Clinical Trial registry name and registration number:
Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD), NCT02966028
CHARACTERISTICS OF INDICATORS OF CENTRAL HEMODYNAMICS OF CADETS OF MARINE UNIVERSITY IN THE PERIOD OF LONG SWIMMING
Authors: Gudkov A. B. , Shcherbina A. F. , Popova O. N. , Nikanov A. N. 
Published: April 2021

Goal. To reveal the peculiarities of central hemodynamics of cadets of a marine university in the conditions of a five-month sailing.Materials and methods. A survey of 70 cadets on board of a sailing training vessel was carried out in the dynamics of a five-month voyage (165 days). Hemodynamic indicators were monitored before entry on duty. For the statistical processing of the results, the SPSS software, v 17.0 (IBM) was used.Results and its discussion. The first two months are characterized by stable indicators of myocardial contractile function, which begins to change from the third month. In the third month, signs of mobilization of the circulatory function appear, which is expressed in an increase in blood pressure (p<0.05) and blood pressure (p<0,05) (by 6.6% and 14%, respectively).The fourth and fifth months are characterized by a further activation of the compensatory-adaptive mechanisms of hemodynamics: an increase in blood pressure (p<0,05), blood pressure (p<0,001), as well as MVC (p<0,05) due to an increase in heart rate (p<0,001), which indirectly indicates a decrease in efficiency in the work of the cardiovascular system.
Statistical properties of linear Majorana fermions
Authors: Lima Francisco Cleiton , Moreira Allan , Machado Laura , ALMEIDA CARLOS ALBERTO 
Published: April 2021

A Majorana fermion is the single fermionic particle that is its own antiparticle. Its dynamics is determined by the Majorana equation, where the spinor field is by definition equal to its charge-conjugate field. In this paper, we investigated Shannon’s entropy of linear Majorana fermions to understand how this quantity is modified due to an external potential of the linear type linear. Subsequently, we turn our attention to the construction of an ensemble of these Majorana particles to study the thermodynamic properties of the model. Finally, we show how Shannon’s entropy and thermodynamic properties are modified under the linear potential action.
Keywords: Majorana Fermions; Thermodynamic properties; Shannon’s Entropy.
POR UMA EDUCAÇÃO EQUITATIVA E EMANCIPATÓRIA: RECURSOS EDUCACIONAIS ABERTOS (REA) COMO DISPOSITIVOS DE AUTORIA E DEMOCRATIZAÇÃO CURRICULAR
Authors: Jacques Juliana Sales , Mallmann Elena Maria , Mazzardo Mara Denize 
Published: April 2021

Recursos Educacionais Abertos são dispositivos de autoria e democratização curricular. A questão central é se potencializam construção teórico-prática visando comprometimento político-pedagógico para democratização do conhecimento, desenvolvimento profissional e fortalecimento da diversidade no planejamento-implementação-avaliação curricular. À luz dos postulados teórico-metodológicos da pesquisa-ação, analisamos a formação continuada de professores da Educação Básica da rede pública do Rio Grande do Sul, materializada no Small Open Online Course “REA: educação para o futuro”. Inferimos que o curso flexibiliza a formação porque coloca em interação professores de várias regiões, contextos escolares e áreas do conhecimento. Portanto, fomenta autoria e compartilhamento aberto de produções didáticas a fim de que possam ser recontextualizadas abrindo caminhos para educação equitativa e emancipatória.
The Animal in Pope’s Essay on Man
Authors: Smith Michael 
Published: April 2021

Why are there so many animals referenced in Alexander Pope’s poem Essay on Man? Traditionally, animals were separated from man throughout history. Namely, the animal was denied logos and access to the polis. However, this article claims that neither of these traditions hold true throughout Pope’s work. Rather, man is placed on a level on par with the animal in order to “vindicate the ways of God to man,” Pope’s explicit purpose of the poem. The article concludes that the agnostic figure of the animal, oddly, becomes the “guarantor” of God’s ways in the eyes of man through its comparison with man.
Espacios urbanos, jóvenes habitantes de calle y covid-19
Authors: Gómez Granda Pablo Andrés , Mena Rodríguez Victoria Eugenia 
Published: April 2021

Los proyectos urbanos propuestos por sucesivas administraciones de Bogotá con el propósito de resolver la problemática de los/as jóvenes habitantes de calle han sido formulados como respuestas a problemas físico-espaciales y de salud pública asociados con el consumo de drogas. La actual coyuntura de emergencia sanitaria global evidencia que estos proyectos vehiculizan tecnologías de poder que procuran el fenómeno de desespacializacion. Además de estudiar la problemática descrita, en el presente artículo se analiza una serie de elementos espaciales adecuados a la espacialización de los/as jóvenes habitantes de calle expuestos al covid-19.
Epidermal Growth Factor Inhibitor-induced Cutaneous Toxicity Improves with Moisturizers
Authors: Morino Ichiko , Okuno Aika , Hirakawa Yuka , Saya Yumiko , Murakami Yumi , Furukawa Fukumi , Matsunaka Hiroshi 
Published: April 2021

Although epidermal growth factor receptor (EGFR) inhibitors are one of the most effective treatment options for lung cancer, they frequently cause cutaneous toxicity that can lead to treatment discontinuation. Dryness, which is a common form of cutaneous toxicity, is usually treated using medical moisturizing agents. We aimed to investigate the treatment of cutaneous toxicity caused by EGFR inhibitors by comparing patients who used a cosmetic moisturizer with those who used conventional medical moisturizers. This study included 12 patients with lung cancer, who were receiving EGFR inhibitors and using topical medical moisturizers. The participants were assigned to a group that continued using medical moisturizers or a group that began using NOV® skin cream D. The study’s findings showed that like conventional medical moisturizers, NOV®skin cream D improved the cutaneous dryness caused by EGFR inhibitors and that it might additionally improve patients’ quality of life. Also, we obtained novel findings that NOV® skin cream D normalized keratinization, which is a component of normal skin cell differentiation impeded by EGFR inhibitors. Hence, the cosmetic moisturizer may help to prevent the discontinuation of EGFR inhibitors, thereby ensuring their continuous therapeutic effects.
Cutaneous seeding of transitional cell carcinoma of the urinary bladder after placement of a subcutaneous ureteral bypass device in a dog with bilateral ureteral obstruction
Authors: Merickel Joshua L. , Lawrence Jessica , Young Shamar J. , Thomson Christopher B. 
Published: April 2021

Abstract

CASE DESCRIPTION
A 12-year-old spayed female Jack Russell Terrier was presented with pollakiuria and stranguria.

CLINICAL FINDINGS
Transitional cell carcinoma (TCC) of the urinary bladder trigone and urethra was diagnosed via CT, cystoscopic, and histologic examinations. Azotemia developed 2 weeks following diagnosis, secondary to bilateral ureteral obstruction.

TREATMENT AND OUTCOME
Percutaneous antegrade ureteral stenting was unsuccessful; therefore, a subcutaneous ureteral bypass (SUB) device with 2 nephrostomy and 1 cystostomy catheters was surgically placed. Two months following placement of the SUB device, the dog developed a firm, multilobulated cutaneous mass at the site of the subcutaneous access port of the SUB device. Results of cytologic examination of cells aspirated from the mass were consistent with TCC. Within 1 month of confirmation of TCC of the cutaneous mass, the mass was ulcerated and infected, and the dog was euthanized because of signs of pain and perceived poor quality of life.

CLINICAL RELEVANCE
Seeding of neoplastic cells is a known complication of needle aspiration or biopsy or surgery in people and dogs with carcinomas. The occurrence of TCC at the SUB port site suggested caution with the placement of a SUB device in dogs with obstructive TCC.
Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-detomidine-butorphanol, tiletamine-zolazepam-xylazine-butorphanol, and ketamine-detomidine-butorphanol in pigs
Authors: Chang Li-Jen , Ko Jeff C. , Weil Ann B. , Weng Hsin-Yi 
Published: April 2021

Abstract

OBJECTIVE
To evaluate and compare the anesthetic, analgesic, and cardiorespiratory effects of tiletamine-zolazepam-detomidine-butorphanol (TZDB), tiletamine-zolazepam-xylazine-butorphanol (TZXB), and ketamine-detomidine-butorphanol (KDB) in pigs and to assess anesthetic recovery duration and quality following administration of tolazoline as a reversal agent.

ANIMALS
11 healthy 2.5-month-old castrated male Landrace mixed-breed pigs.

PROCEDURES
In a randomized, blinded crossover study design, pigs received the following anesthetic combinations, IM: TZDB (tiletamine-zolazepam [3 mg/kg {1.36 mg/lb}], detomidine [0.18 mg/kg {0.08 mg/lb}], and butorphanol [0.12 mg/kg {0.05 mg/lb}]); TZXB (tiletamine-zolazepam [4 mg/kg {1.8 mg/lb}], xylazine [4 mg/kg], and butorphanol [0.2 mg/kg {0.09 mg/lb}]); and KDB (ketamine [8 mg/kg {3.63 mg/lb}], detomidine [0.18 mg/kg], and butorphanol [0.3 mg/kg {0.14 mg/lb}]). A 7-day washout period was provided between treatments. At 45 minutes of anesthesia, pigs received tolazoline (2 mg/kg [0.9 mg/lb], IM; n = 6) treatment or control (5) treatment with saline (0.9% NaCl) solution.

RESULTS
All anesthetic combinations induced anesthesia. Endotracheal intubation was completed within 5 minutes after anesthetic administration in all pigs, except in 2 pigs following administration of KDB. Durations (mean ± SD) of endotracheal intubation and lateral recumbency in pigs that did not receive tolazoline were 55.3 ± 4.8 minutes, 83.8 ± 15.8 minutes, and 28.2 ± 4.5 minutes and 112.4 ± 18.7 minutes, 117.2 ± 16.7 minutes, and 79.7 ± 6.0 minutes, respectively, for the TZDB, TZXB, and KDB anesthetic treatments. Tolazoline significantly shortened the duration of anesthetic recovery for all anesthetic treatments without affecting the recovery quality.

CONCLUSIONS AND CLINICAL RELEVANCE
All 3 anesthetic combinations were suitable for providing anesthesia in pigs. Tolazoline administration shortened the duration of anesthetic recovery without affecting the quality of recovery.
Pleas for Respectability: Eighteenth-Century Women Writers Theorizing the Novel
Authors: Precup Amelia 
Published: April 2021

Abstract
The emergence and development of the modern novel used to be viewed as a largely masculine affair. However, over the past few decades, researchers and scholars have started to re-evaluate and acknowledge the importance of women’s literary and theoretical work to the rise and evolution of the genre. This article adds to these revisionist efforts by contributing to the ongoing discussion on the theoretical legacy left by some of the most notable British women writers of the long eighteenth century. The article analyses several texts (prefaces, dedications, dialogues, essays, reviews) in which they expressed their perspectives on questions situated at the core of the eighteenth-century debates concerning the novel. The critical and theoretical perspectives advanced by these writers are approached as contributions to the novel’s status as a respectable literary genre and, implicitly, as self-legitimizing efforts.
The Remediation of the Epic in Digital Games: The Elder Scrolls V: Skyrim
Authors: Melnic Vlad 
Published: April 2021

Abstract
This paper examines whether certain computer games, most notably RPGs, can be thought of as examples of the postmodern epic. Drawing on more recent critical frameworks of the epic, such as the ones proposed by Northrop Frye, Adeline Johns-Putra, Catherine Bates or John Miles Foley, the demonstration disembeds the most significant diachronic features of the epic from its two main media of reproduction, that of text and oral transmission, in order to test their fusion with the virtual environment of digital games. More specifically, I employ the concept of “epic mode” in order to explain the relevance of The Elder Scrolls: Skyrim for the history of the epic typology, which must now be understood as transmedial. I illustrate the manner in which this representative title assimilates the experience and performance of the epic, as well as several meaningful shifts in terms of genre theory, the most notable of which is an intrinsic posthuman quality. The experience of play inherent to Skyrim does not only validate the latter as an authentic digital epic of contemporary culture, but it also enhances the content, role and impact of the typology itself, which is yet far from falling into disuse.1
“One does what one can (on fait ce qu’on peut)”: Joseph Conrad as Translator
Authors: Stevenson Randall 
Published: April 2021

Abstract
Joseph Conrad’s fiction – Lord Jim especially – contains several instances of characters struggling with translation, or with foreign languages more generally, or transferring speech or syntactic patterns from one language to another. These features have much to suggest about Conrad’s own multilingual early life and his eventual adoption of English for his writing. They also have wider implications concerning his vision and tactics as a novelist – including his reliance on French fiction, and his regular emphases on cultural difference and on the cognitive and epistemological challenges of communicating experience. These challenges, in turn, initiate or anticipate concerns widely apparent in modernist fiction, indicating stresses in an advancing, globalised modernity which made its innovations so necessary. Appreciating Conrad’s interest in translation elucidates and confirms Fredric Jameson’s judgement of his writing as a key factor in the emergence of modernism in the early twentieth century.
Pharmaco-Botanical Mapping and Evaluation of the Medicinal Flora – Potencial along the Niraj and Târnava Mică Rivers
Authors: Nagy Zsolt 
Published: April 2021

Abstract
This study offers the partial results of the botanical studies, botanical cartography, and the evaluation of the medicinal flora potential in the ROSCI0297 Natura 2000 area (Dealurile Târnavei Mici – Bicheș). From March 4th, 2016 to March 3th, 2017, in a 1000 ha sample area and a 34 days long fieldwork the specific location of 101 officially applied medicinal plant species was identified and mapping was achieved. Simultaneously, 26 medicinal plant analogues, 300 other valuable taxa (e. g. plants under protection, rare orchids etc.), and the cartography of invasive plants were documented. Another important result of the first year is the identification, listing and analysis of the reshaping, influential and impairing factors of the vegetation and habitats.
The Effect of Music on Heart Rate Variability (Review)
Authors: Parizek D , Sladicekova K , Tonhajzerova I , Veterník M , Jakus J 
Published: April 2021

Abstract
Music therapy and the use of music in medical practice have now become rapidly advancing and promising areas of non-invasive alternative medicine. However, the opinions of physicians and therapists on the implementation of this complementary therapy, especially in the process of treating the patient, are constantly different. In addition, the effect of music and individual methodological procedures are not uniform and defined in detail. Therefore, this review study summarizes the results and conclusions of some selected high-quality publications over the last decade and makes suggestions for improvement and further research. It focuses mainly on the evaluation of changes in heart rate variability (HRV) as an indicator of the activity of the autonomic nervous system (ANS) in connection with the application of music in the process of passive music therapy.
Correlation of Increased Total Serum Immunoglobulin E Levels and Hidradenitis Suppurativa
Authors: Ballova A , Vorcakova K , Pec J 
Published: April 2021

Abstract

Introduction: Hidradenitis suppurativa is a chronic inflammatory skin disease with a typical formation of inflamed nodules, abscesses, and sinus tracts usually in the axillary, inguinal, and anogenital region. We decided to investigate the possible association of hidradenitis suppurativa and total IgE elevation and to explore the patients’ characteristics which can be related to high IgE levels.

Methods: We performed a retrospective observational study which included 67 patients with moderate-to-severe stage of hidradenitis suppurativa followed up in our outpatient dermatology department. Total IgE, IgA, IgG, IgM, and CRP serum levels were measured. A personal and family history was taken. We asked them about allergic diseases and cigarette smoking and determined the basic parameters such as the weight and height of the patients.

Results: Elevated total IgE levels were noticed in 21 patients (31.3%), of which 6 had a history of allergic disorder. Three of them had allergic rhinoconjunctivitis and the other three were suffering from atopic dermatitis. The mean total IgE level was 203.0 IU/ml with a maximum value of 1,954 IU/ml. Analysis of the factors, such as cigarette smoking, sex, elevated CRP, body mass index, and the number of affected areas, did not show an association with increased IgE levels.

Conclusion: Our study showed a higher mean value of total IgE in patients with moderate to severe hidradenitis suppurativa than in the general population. However, we did not confirm an association with any characteristics of the patients. Limitations of this work include a small number of patients and a lack of the control group, therefore further and more extensive studies are needed to support these results.
Theoretical study of lumichrome, 1-methyl-lumichrome and lumiflavin binding ability with thymine
Authors: Cagardová Denisa , Michalík Martin , Lukeš Vladimír 
Published: April 2021

Abstract
Gas-phase geometry and electronic structure of lumichrome, 1-methyl-lumichrome and lumiflavin in the electronic ground state and their excited states were investigated using the Density Functional Theory. Their binding ability with thymine was estimated for model van der Waals dimers with two intermolecular hydrogen bonds. The influence of hydrogen bonds on their photophysical properties was analyzed. Obtained theoretical data were compared with available experimental absorption and fluorescence spectra.