bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi Pelaksanaan Pos Pembinaan Terpadu (Posbindu) PTM di Kabupaten Pesisir Barat
Authors: Susilawati Nova , Adyas Atikah , Djamil Achmad 
Published: September 2021

Tujuan penelitian yaitu mengetahui efektivititas posbindu dalam pengendalian dan pencegahan penyakit tidak menular di Kabupaten Pesisir Barat. Penelitian kualitatif pendekatan fenomenologi dan didukung data kuantitatif kasus PTM unutuk menilai effect Posbindu dalam pengendalian dan pencegahan PTM. Informan dalam penelitian ini berjumlah 19 informan terdiri dari Petugas Posbindu Puskesmas sebanyak 5 informan, kader posbindu berjumlah 4 informan dan peserta posbindu berjumlah 5 orang dan 5 informan Pembina Posbindu Puskemas dipilih menjadi triagulasi dalam penelitian ini. Hasil penelitian terhadap efektivitas posbindu di kabupaten pesisir barat masih ditemukannya masalah pada input meliputi; sumberdaya, sarana prasarana, pendanaan, proses dan output sehingga pelaksanaan Posbindu di Kabupaten Pesisir Barat belum efektif dan berdampak pada tidak terkendalinya kasus hipertensi dibuktikan dengan capaian pemeriksaan penderita hipertensi sebesar 7,76% dan hasil pemeriksaan tekanan darah menunjukkan 429 penderita hipertensi berada pada rentang kategori buruk. Pelaksanaan Posbindu belum Efektiv dalam pengendalian dan pencegahan penyakit tidak menular di Kabupaten Pesisir Barat
Marker-Assisted Pyramiding of Multiple Disease Resistance Genes in Coffee Genotypes (Coffea arabica)
Authors: de Almeida Dênia Pires , Caixeta Eveline Teixeira , Moreira Karoliny Ferreira , de Oliveira Antonio Carlos Baião , de Freitas Kátia Nogueira Pestana , Pereira Antônio Alves , Rosado Renato Domiciano Silva , Zambolim Laércio , Cruz Cosme Damião 
Published: September 2021

The use of resistant cultivars is the most effective strategy for controlling coffee leaf rust caused by the fungus Hemileia vastatrix. To assist the development of such cultivars, amplified fragment-length polymorphism (AFLP) markers linked to two loci of coffee resistance to races I and II as well as pathotype 001 of H. vastatrix were converted to sequence-characterized amplified region (SCAR) and cleaved amplified polymorphic site (CAPS) markers. In total, 2 SCAR markers and 1 CAPS marker were validated in resistant and susceptible parents as well as in 247 individuals from the F2 population. The efficiency of these markers for marker-assisted selection (MAS) was evaluated in F2:3 and backcross (BCrs2) populations genotyped with the developed markers and phenotyped with race II of H. vastatrix. The markers showed 90% efficiency in MAS. Therefore, the developed markers, together with molecular markers associated with other rust resistance genes, were used for F3:4 and BCrs3 coffee selection. The selected plants were analyzed using two markers associated with coffee berry disease (CBD) resistance, aiming for preventive breeding. MAS of F3:4 and BCrs3 individuals with all resistance loci was feasible. Our phenotypic and genotypic approaches are useful for the development of coffee genotypes with multiple genes conferring resistance to coffee leaf rust and CBD.
Beta vulgaris rubra L. (Beetroot) Peel Methanol Extract Reduces Oxidative Stress and Stimulates Cell Proliferation via Increasing VEGF Expression in H2O2 Induced Oxidative Stressed Human Umbilical Vein Endothelial Cells
Authors: Al-Harbi Laila Naif , Pandurangan Subash-Babu , Al-Dossari Alhanouf Mohammed , Shamlan Ghalia , Salamatullah Ahmad Mohammad , Alshatwi Ali A , Alotiby Amna Abdullah 
Published: September 2021

The antioxidant capacity of polyphenols and flavonoids present in dietary agents aids in arresting the development of reactive oxygen species (ROS) and protecting endothelial smooth muscle cells from oxidative stress/induced necrosis. Beetroot (Beta vulgaris var. rubra L.; BVr) is a commonly consumed vegetable representing a rich source of antioxidants. Beetroot peel’s bioactive compounds and their role in human umbilical vein endothelial cells (HUVECs) are still under-researched. In the present study, beetroot peel methanol extract (BPME) was prepared, and its effect on the bio-efficacy, nuclear integrity, mitochondrial membrane potential and vascular cell growth, and immunoregulation-related gene expression levels in HUVECs with induced oxidative stress were analysed. Gas chromatography–mass spectroscopy (GC-MS) results confirmed that BPME contains 5-hydroxymethylfurfural (32.6%), methyl pyruvate (15.13%), furfural (9.98%), and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-Pyran-4-one (12.4%). BPME extract effectively enhanced cell proliferation and was confirmed by MTT assay; the nuclear integrity was confirmed by propidium iodide (PI) staining assay; the mitochondrial membrane potential (Δψm) was confirmed by JC-1 staining assay. Annexin V assay confirmed that BPME-treated HUVECs showed 99% viable cells, but only 39.8% viability was shown in HUVECs treated with H2O2 alone. In addition, BPME treatment of HUVECs for 48 h reduced mRNA expression of lipid peroxide (LPO) and increased NOS-3, Nrf-2, GSK-3β, GPX, endothelial nitric oxide synthase (eNOS) and vascular cell growth factor (VEGF) mRNA expression levels. We found that BPME treatment decreased proinflammatory (nuclear factor-κβ (F-κβ), tissue necrosis factor-α (TNF-α), toll-like receptor-4 (TLR-4), interleukin-1β (IL-1β)) and vascular inflammation (intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), EDN1, IL-1β)-related mRNA expressions. In conclusion, beetroot peel treatment effectively increased vascular smooth cell growth factors and microtubule development, whereas it decreased vascular inflammatory regulators. BPME may be beneficial for vascular smooth cell regeneration, tissue repair and anti-ageing potential.
Critical Solutal Marangoni Number Correlation for Short-Scale Convective Instabilities in Drying Poly(vinyl acetate)-Methanol Thin Films
Authors: Tönsmann Max , Scharfer Philip , Schabel Wilhelm 
Published: September 2021

A new empiric correlation for the critical solutal Marangoni number as function of the Péclet and Schmidt numbers is proposed. It is based on previously published experimental flow field data in drying poly(vinyl acetate)-methanol films with an initial thickness in the range of 20–100 μm and an initial solvent load of 1 to 2 gMeOH/gPVAc, as well as newly derived concentration profile measurements and 1D drying simulations. The analysis accounts for realistic transient material properties and describes the occurrence of short-scale convective Marangoni (in)stabilities during the entire drying process with an accuracy of 9%. In addition, the proposed correlation qualitatively follows trends known from theory. As convective Marangoni instabilities in drying polymer films may induce surface deformations, which persist in the dry film, the correlation may facilitate future process design for either thin films with uniform thickness or deliberate self-assembly.
A Two-Stage Deep Learning Registration Method for Remote Sensing Images Based on Sub-Image Matching
Authors: Chen Yuan , Jiang Jie 
Published: September 2021

The registration of multi-temporal remote sensing images with abundant information and complex changes is an important preprocessing step for subsequent applications. This paper presents a novel two-stage deep learning registration method based on sub-image matching. Unlike the conventional registration framework, the proposed network learns the mapping between matched sub-images and the geometric transformation parameters directly. In the first stage, the matching of sub-images (MSI), sub-images cropped from the images are matched through the corresponding heatmaps, which are made of the predicted similarity of each sub-image pairs. The second stage, the estimation of transformation parameters (ETP), a network with weight structure and position embedding estimates the global transformation parameters from the matched pairs. The network can deal with an uncertain number of matched sub-image inputs and reduce the impact of outliers. Furthermore, the sample sharing training strategy and the augmentation based on the bounding rectangle are introduced. We evaluated our method by comparing the conventional and deep learning methods qualitatively and quantitatively on Google Earth, ISPRS, and WHU Building Datasets. The experiments showed that our method obtained the probability of correct keypoints (PCK) of over 99% at α = 0.05 (α: the normalized distance threshold) and achieved a maximum increase of 16.8% at α = 0.01, compared with the latest method. The results demonstrated that our method has good robustness and improved the precision in the registration of optical remote sensing images with great variation.
Five-year survival and biomarkers of sympatho-adrenal, neurohumoral, immune activation, fibrosis in patients with early and late superresponse to cardiac resynchronization therapy
Authors: Kuznetsov V. A. , Enina T. N. , Gorbatenko E. A. , Soldatova A. M. , Shirokov N. E. , Petelina T. I. , Winemark L. A. 
Published: September 2021

Methods. 82 SR (80.5% men; mean age 60.4±9.3; 45 (54.9%) with CAD) were divided according to period of LVESV maximum decrease: Gr.1 (n=19)- <24months (14.0 [8.0; 21.0]), Gr.2 (n=63)->24 months (59[43.0; 84.0]). Dynamics of echocardiography, adrenaline (ADR) plasma levels, norepinephrine (NE), interleukins (IL) 1β, 6, 10, TNF-α, NT-proBNP, MMP-9, TIMP-1, 4, were examined. Five-year survival was estimated by Kaplan-Meier method. ROC analysis and logistic regression were applied to identify late CRT response factors.Results. Initially, groups didn’t differ by clinical and echocardiographic findings. At baseline, Gr.2 had larger ADR (p=0.049) and NE (p=0.061). Rate of change in NE was opposite in groups during CRT: ΔNE increased in Gr.1 and decreased in Gr.2. (p=0.015), which was associated with better reverse cardiac remodeling (lower LV end systolic diameter, LV end diastolic diameter, LVESV, LV end diastolic volume), decrease in activity of immune inflammation (decrease in levels of IL-1β, 6, 10, TNF-α) and fibrosis formation (decrease in TIMP- 1, enhancement of MMP-9/TIMP-1). Cut-off value of 2.55 ng/ml for NE complied with the highest sensitivity (80%), specificity (60%), AUC=0.693 (p=0.011) for predicting late CRT response. Proportion of patients with NE<2.55 ng/ml was 21.1% in Gr.1 and 59.7% in Gr.2, (p=0.003), mean follow-up period was 45.8±0.3 and 94.9±35.9 months (p<0.001), respectively All SR of Gr.2 were alive within 5 years, survival rate was 50% in Gr.1 (Log-Rank test<0.001). NE was associated with late CRT response (OR 8.0 (95%CI 1.5-42.8), p=0.015).Conclusion. Late CRT response was accompanied by increased life expectancy, better 5-year survival, associated with greater reverse cardiac remodeling, decreased fibrosis activity, immune, neurohumoral, sympathoadrenal activation. When NE level was less than 2.55 ng/ml, probability of late response increased 8-fold.
Cardiac contractility modulation therapy in elderly patients with chronic heart failure: results of the 12-month follow-up
Authors: Chugunov I. A. , Davtyan K. V. , Topchyan A. H. , Mironova N. A. , Gupalo E. M. 
Published: September 2021

Aim. This study aimed to evaluate the efficacy and safety of cardiac contractility modulation (CCM) therapy in elderly patients with heart failure with reduced ejection fraction (HFrEF).Methods. Sixteen patients older than 65 years old (median age 70 years) undergoing CCM Optimizer (Impulse Dynamics) device implantation due to HFrEF (NYHA class II - 9 (56%), III - 4 (25%), IV - 3 (19%)) were enrolled in this two-center observational study. Before implantation 6-minute walk test (6MWT), transthoracic echocardiography (TTE) was performed on all patients, and NTproBNP levels were assessed. The follow-up duration was 12 months with 2, 6, 12-month follow-up visits. Control 6MWT, TTE and NTproBNP tests were performed at 6-month and 12-month follow-up visits.Results. Two patients died during follow-up due to HF decompensation. The remaining patients showed a significant improvement in 6MWT (350 m vs 402.5 m, p=0,01). We also noted a tendency towards the left ventricular EF improvement (33% vs 40%, p=0,2) and lower values of NTproBNP levels (1112 pg/ml vs 527 pg/ml, p=0,19).Conclusion. CCM therapy is a safe and efficient additional treatment option to manage elderly patients with HFrEF for reducing signs and symptoms of HF.
Pengaruh Manajemen Modal Kerja Terhadap Profitabilitas Dengan Moderasi Financial Constraints
Authors: Artha Merika Indah Puspita Sari  , Rahmat Setiawan  
Published: September 2021

Abstract
This study aims to determine the effect of working capital management on profitaility. Working capital management here is seen through cash conversion cycle company. The study also looked at the moderating effect of financial constraints on the effect of working capital management on profitaility. The research used purposive sampling method and the analytical method used in this study is multiple linear regression. Based on the results of the analysis it can be concluded that cash conversion cycle has a significant negative effect on profitability. The financial constraints variabel strengthens the negative effect of the cash conversion cycle on profitability.

Keywords: working capital management, cash conversion cycle, profitability, and financial constraints.
Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh manajemen modal kerja terhadap profitabilitas. Manajemen modal kerja disini dilihat melalui siklus konversi kas perusahaan. Penelitian ini juga melihat efek moderasi financial constraints pada pengaruh manajemen modal kerja terhadap profitabilitas. Metode pengambilan sampel menggunakan purposive sampling, dan metode analisis yang digunakan pada penelitian ini adalah metode regresi linier berganda. Berdasarkan hasil analisis dapat disimpulkan bahwa manajemen modal kerja melalui siklus konversi kas berpengaruh negatif signifikan terhadap profitabilitas. Variabel financial constraints memperkuat pengaruh negatif siklus konversi kas terhadap profitabilitas.
Kata Kunci: manajemen modal kerja, siklus konversi kas, profitabilitas dan financial constraints.
O preconceito na educação física escolar: percepção de professores da rede pública de município do sul do Brasil
Authors: Santos Maiara Scheila Freitas , Montiel Fabiana Celente , Silva Felipe Fernando Guimarães da , Ribeiro José Antônio Bicca , Afonso Mariângela da Rosa , Teixeira Fernanda de Souza 
Published: September 2021

INTRODUÇÃO: O presente trabalho versa sobre as manifestações de preconceito identificadas por professores de Educação Física, da rede pública de ensino de um município do sul do Brasil, e as consequências de tais manifestações no andamento de suas aulas. OBJETIVO: Buscou-se identificar os tipos de preconceitos observados nas aulas de Educação Física e as consequências para: o aluno agressor, o aluno que sofre o preconceito e a turma na qual estão inseridos. MÉTODOS: Trata-se de um estudo com abordagem qualitativa, de caráter descritivo, em que a coleta de dados se deu por meio de entrevista. Para a análise dos dados utilizou-se a técnica de análise de conteúdo. Foram entrevistados 27 professores de Educação Física, sendo 11 homens e 16 mulheres. RESULTADOS: Os resultados apontaram que os tipos de preconceitos mais frequentemente identificados pelos professores nas aulas de Educação Física são étnico-racial, de diferenças corporais e aqueles relativos à classe social. Os dados demonstraram que o preconceito fomenta a agressividade; além de causar traumas, diminuição da autoestima e redução na participação das atividades propostas a quem sofre a agressão. CONCLUSÃO: Ficou evidenciada a carência de ações mais efetivas relacionadas à redução das manifestações de preconceito dentro do ambiente escolar.
A percepção dos gestores das escolas de ensino médio em Fortaleza sobre a importância da educação física como componente curricular
Authors: Moreno Danilo Bastos , Andrade César Augusto Barroso de , Alves Maria Emanuela Cordeiro , Rodrigues Leonardo Coelho 
Published: September 2021

INTRODUÇÃO: A Educação Básica no Brasil passou por momentos bem conturbados durante a década de 2010. Dentre esses momentos pode-se destacar a evolução da MP n° 746/2016 para a Lei 13.415/2017 e a instituição do Novo Ensino Médio. A partir desta Lei, a Educação Física (EF) poderia ser excluída do rol de disciplinas curriculares obrigatórias da Educação Básica. Em meio a esse cenário, vários movimentos foram realizados para manter a EF como obrigatória na etapa do Ensino Médio na escola. OBJETIVO: Verificar a percepção dos gestores de escolas de ensino médio, pertencentes a rede pública do estado do Ceará, sobre a importância das aulas de EF. MÉTODOS: O estudo caracteriza-se como uma pesquisa de campo e exploratória, com caráter transversal quanti-qualitativo, com a aplicação de um questionário do tipo Likert, com itens de múltipla escolha acerca de cada pergunta, variando as opções entre “discordo total”, “discordo parcialmente”, “concordo parcialmente” e “concordo totalmente”. Participaram do estudo gestores de escolas regulares e profissionalizantes. A amostra do estudo foi composta por 40 gestores de escolas regulares e de tempo integral de um total de 119 escolas, perfazendo 33% das escolas elencadas como público para o atual estudo. A coleta de dados ocorreu dentre os anos de 2018 e 2019. RESULTADOS: Foi achado que os gestores consideram a EF como importante à formação integral do estudante (92,5%), que a carga horária semanal deveria ser aumentada (62,5%) e que a disciplina contribui para uma melhoria da prática de atividade física dos estudantes. CONCLUSÃO: A partir da percepção dos gestores das escolas estaduais da cidade de Fortaleza (CE), o componente curricular EF é importante para a formação dos estudantes. Bem como, eles consideram que a carga horária da disciplina poderia ser aumentada por conta da importante influência da disciplina sobre a prática de atividade física.
A Systematic Literature Review of the Epidemiology, Health-Related Quality of Life Impact, and Economic Burden of Immunoglobulin A Nephropathy
Authors: Kwon Christina Soeun , Daniele Patrick , Forsythe Anna , Ngai Christopher 
Published: September 2021

Introduction: This systematic literature review analyzed published evidence on IgA nephropathy (IgAN), focusing on US epidemiology, health-related quality of life (HRQoL), and economic burden of illness. Methods: Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, Embase®, MEDLINE®, Cochrane, and Econlit (January 2010 to June 2020) were searched, along with relevant congresses (2017-2020). Results: Of 123 epidemiologic studies selected for data extraction, 24 reported IgAN diagnosis rates ranging from 6.3% to 29.7% among adult and pediatric patients undergoing renal biopsy, with all reported US rates <15%. No US studies reported IgAN prevalence. A meta-analysis of US studies calculated an annual incidence of 1.29/100 000 people, translating to an annual US incidence of 4236 adults and children. Relative to Europe, the United States had more patients diagnosed with IgAN in later chronic kidney disease stages. US rates of transition to end-stage renal disease (ESRD) ranged from 12.5% to 23% during 3-3.9 years of observation, rising to 53% during 19 years of observation. Across 8 studies reporting HRQoL, pain and fatigue were the most reported symptoms, and patients consistently ranked kidney function and mortality as the most important treatment outcomes. Patients with glomerulopathy reported worse mental health than healthy controls or hemodialysis patients; proteinuria was significantly associated with poorer HRQoL and depression. Conclusion: While economic evidence in IgAN remains sparse, management of ESRD is a major cost driver. IgAN is a rare disease where disease progression causes increasing patient burden, underscoring the need for therapies that prevent kidney function decline and HRQoL deterioration while reducing mortality.
TO THE QUESTION ABOUT DEFINITION OF THE TERM «MILITARY CHARGES»
Authors: Савелов Г.А. , Алешин А.И. , Калач Г.П. , Степкин К.А. , Баранов Е.В. 
Published: September 2021

статья посвящена исследованию такого термина как «военные сборы» с целью изложение исчерпывающей дефиниции данного термина ввиду малой научной разработанности данной темы
the article is devoted to the study of such a term as "military training" in order to present an exhaustive definition of this term in view of the low scientific development of this topic
fbst: An R package for the Full Bayesian Significance Test for testing a sharp null hypothesis against its alternative via the e value
Authors: Kelter Riko 
Published: September 2021

AbstractHypothesis testing is a central statistical method in psychology and the cognitive sciences. However, the problems of null hypothesis significance testing (NHST) and p values have been debated widely, but few attractive alternatives exist. This article introduces the R package, which implements the Full Bayesian Significance Test (FBST) to test a sharp null hypothesis against its alternative via the e value. The statistical theory of the FBST has been introduced more than two decades ago and since then the FBST has shown to be a Bayesian alternative to NHST and p values with both theoretical and practical highly appealing properties. The algorithm provided in the package is applicable to any Bayesian model as long as the posterior distribution can be obtained at least numerically. The core function of the package provides the Bayesian evidence against the null hypothesis, the e value. Additionally, p values based on asymptotic arguments can be computed and rich visualizations for communication and interpretation of the results can be produced. Three examples of frequently used statistical procedures in the cognitive sciences are given in this paper, which demonstrate how to apply the FBST in practice using the package. Based on the success of the FBST in statistical science, the package should be of interest to a broad range of researchers and hopefully will encourage researchers to consider the FBST as a possible alternative when conducting hypothesis tests of a sharp null hypothesis.
Faktor yang Mempengaruhi Tax Avoidance dengan Ukuran Perusahaan sebagai Variabel Kontrol
Authors: Mariani Desy , Suryani Suryani 
Published: September 2021

For companies, taxes are costs that reduce profits. The company wants to pay the minimum tax so that the profit earned by the company does not decrease, while from the government side, tax collection is used to finance the implementation of state development. This difference also causes taxpayers to tend to avoid taxes to reduce their tax burden, so that state revenue from the tax sector is still not maximized.
This study aims to determine the factors that affect tax avoidance with company size as a control variable. This study uses a sample of trading, service and investment companies in the wholesale and retail trade sub-sector listed on the Indonesia Stock Exchange for the period 2014-2018. The sampling method used in this study was purposive sampling method, where according to the established criteria, 22 companies were obtained and the data used were secondary data. The analysis technique used in this study is multiple linear regression analysis using the Statistical Product and Service Solutions (SPSS) v.20.0 program. The results show that Leverage, Sales Growth and Company Size have a positive effect on tax avoidance, while liquidity and fixed asset intensity have no effect on tax avoidance, thus company size can control Leverage and Sales Growth to influence tax avoidance.
ПРИМЕНЕНИЕ ОБРАЗОВАТЕЛЬНЫХ КОНСТРУКТОРОВ В ОБУЧЕНИИ ФИЗИКЕ
Authors: Лепехов А.В. , Кузнецова О.В. 
Published: September 2021

В статье рассматриваются место и роль образовательных конструкторов в реализации метапредметного и STEM/STEAM обучения. Описываются возможности применения образовательных конструкторов в обучении физике.
The article discusses the place and role of educational constructors in the implementation of metasubject and STEM/STEAM learning. The possibilities of using educational constructors in teaching physics are described.