bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burkitt-type lymphoma incidentally found as the cause of acute appendicitis: a case report and review of literature
Authors: Shahmanyan Davit , Saway Brian , Palmerton Hannah , Rudderow John S. , Reed Christopher M. , Wattsman Terri-Ann , Faulks Emily R. , Collier Bryan R. , Budin Robert E. , Hamill Mark E. 
Published: September 2021

Abstract
Background
Appendectomy remains one of the most common emergency operations. Recent research supports the treatment of uncomplicated appendicitis with antibiotics alone. While nonoperative management of appendicitis may be safe in some patients, it may result in missed neoplasms. We present a case of acute appendicitis where the final pathology resulted in a diagnosis of a Burkitt-type lymphoma.

Case presentation
An 18-year-old male presented to the emergency department with 24 h of right lower quadrant pain with associated urinary retention, anorexia, and malaise. Past medical history was significant for intermittent diarrhea and anal fissure. He exhibited focal right lower quadrant tenderness. Workup revealed leukocytosis and CT uncovered acute appendicitis with periappendiceal abscess and no appendicolith. Laparoscopic appendectomy was performed and found acute appendicitis with associated abscess abutting the rectum and bladder. Pathology of the resected appendix reported acute appendicitis with evidence of Burkitt-type lymphoma. A PET scan did not reveal any residual disease. Hematology/oncology was consulted and chemotherapy was initiated with an excellent response.

Conclusions
Appendiceal lymphomas constitute less than 0.1% of gastrointestinal lymphomas. Primary appendix neoplasms are found in 0.5–1.0% of appendectomy specimens following acute appendicitis. In this case, appendectomy allowed for prompt identification and treatment of an aggressive, rapidly fatal lymphoma resulting in complete remission.
Psychometric validation of the Female Sexual Distress Scale-Desire/Arousal/Orgasm
Authors: Derogatis Leonard R. , Revicki Dennis A. , Rosen Raymond C. , Jordan Robert , Lucas Johna , Spana Carl 
Published: September 2021

Abstract
Background
For the treatment of female sexual dysfunction, the most relevant outcome measures are patient-reported treatment effects and changes in symptoms, underscoring the need for reliable, validated patient-reported outcome (PRO) instruments. The aim of this study was to evaluate the psychometric characteristics (validity and reliability) of the Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO) PRO measure, which was adapted from the validated FSDS-Revised (FSDS-R) questionnaire and added 2 questions involving arousal and orgasm.

Methods
Psychometric analyses were based on the data from a multicenter phase 2b dose-finding study that compared the safety and efficacy of bremelanotide versus placebo and were conducted in the evaluable modified intent-to-treat population (N = 325) from that study. Psychometric evaluation of the new items in the FSDS-DAO included confirmatory factor analyses, tests of internal consistency and test–retest reliability, examinations of convergent and discriminant validity, and determination of responsiveness. The validity of the FSDS-DAO was evaluated based on previously developed instruments, including the Female Sexual Function Index (FSFI), General Assessment Questionnaire (GAQ), Women’s Inventory of Treatment Satisfaction (WITS-9), and Female Sexual Encounter Profile-Revised (FSEP-R).

Results
Confirmatory factor analyses demonstrated that the FSDS-DAO items fit very well (Bentler’s comparative fit index of 0.929). Cronbach’s α for the FSDS-DAO total score was ≥ 0.91 at Visits 1, 2, 5, and 12, demonstrating adequate internal consistency reliability. Test–retest reliability was acceptable with an intra-class coefficient of 0.61 and a Spearman’s correlation coefficient score of 0.62 between Visits 1 and 2 (4 weeks). Acceptable construct validity was demonstrated by significant correlations with related PRO scales in the expected directions and magnitude. For example, participants reporting the worst levels of sexual function on the FSFI also showed the worst FSDS-DAO scores at Visits 5 and 12. The FSDS-DAO total score was responsive to change.

Conclusions
Evidence supports the validity and reliability of the FSDS-DAO for assessing sexually related distress in women with female sexual arousal disorder and/or hypoactive sexual desire disorder; the addition of the arousal and orgasm items did not impact the validity and reliability of the measure.
Clinical Trial Registration ClinicalTrials.gov NCT01382719.
A scoping review of deep neural networks for electric load forecasting
Authors: Vanting Nicolai Bo , Ma Zheng , Jørgensen Bo Nørregaard 
Published: September 2021

AbstractThe increasing dependency on electricity and demand for renewable energy sources means that distributed system operators face new challenges in their grid. Accurate forecasts of electric load can solve these challenges. In recent years deep neural networks have become increasingly popular in research, and researchers have carried out many experiments to create the most accurate deep learning models. Players in the energy sector can exploit the increasing amount of energy-related data collected from smart meters to improve the grid’s operating quality. This review investigates state-of-the-art methodologies relating to energy load forecasting using deep neural networks. A thorough literature search is conducted, which outlines and analyses essential aspects regarding deep learning load forecasts in the energy domain. The literature suggests two main perspectives: demand-side management and grid control on the supply side. Each perspective has multiple applications with its challenges to achieve accurate forecasts; households, buildings, and grids. This paper recommends using a hybrid deep learning multivariate model consisting of a convolutional and recurrent neural network based on the scoping review. The suggested input variables should be historical consumption, weather, and day features. Combining the convolutional and recurrent networks ensures that the model learns as many repeating patterns and features in the data as possible.
A QR code based framework for auto-configuration of IoT sensor networks in buildings
Authors: Madsen Simon Soele , Santos Athila Quaresma , Jørgensen Bo Nørregaard 
Published: September 2021

AbstractWorldwide buildings are responsible for about 40% of the overall consumption and contribute to an average of 30% percent of the global carbon emissions. Nevertheless, most current buildings lack efficient energy management systems because such solutions are very expensive, especially when necessary instrumentation needs to be installed after the building’s construction. As an alternative, we purpose the use of IoT sensor networks to retrofit existing medium and large-sized buildings to provide energy management capabilities in a cost-effective way. An IoT network auto-configuration platform for building energy management was developed. In order to efficiently manage metadata related to location and devices, a database using dynamic QR codes was created. Furthermore, we discuss the potential and shortcomings of different sensor-gateway pairing strategies that are applicable to an auto-configuring system. Lastly, we share our implementation of these concepts and demonstrate their use in a medium-sized building case study. The results show a trade-off between optimal configuration and total configuration time with a focus on the quality of the communication signal strength. The proposal provided the necessary automation for a cost-effective energy management system that can be deployed in both new constructions and existing buildings.
Evaluating the CO2 abatement effects of low-carbon city policy in China: a quasi-natural experiment
Authors: Li Qiangyi , Yang Mian , Xu Fei , Yang Fuxia , Xiang Xiaojian 
Published: September 2021

AbstractThe formulation and implementation of Low-Carbon City Policy (LCCP) is an essential initiative for China to build its low-carbon society. Based on the panel data of 282 prefecture-level cities in China from 2003 to 2016, this study evaluates the effects of LCCP implementation on pilot cities’ carbon emission performance using difference-in-differences method, and then the mechanism has also been examined with a mediating effect model. The results show that: first, the LCCP implementation has increased the carbon emission performance of the pilot cities significantly, indicating that it is an effective way to promote the low-carbon transformation of Chinese cities. Second, the positive effects in CO2 performance resulting from LCCP demonstrate significant heterogeneity: in general, the cities in east China, with higher economic development level and in a larger size, achieve more significant CO2 emission reduction than their respective counterparts. The results on the mechanism test imply that the LCCP helps improve pilot cities’ carbon emission performance in three ways, including reducing energy consumption, updating the industrial structure, and promoting technological progress. Finally, some useful policy recommendations are put forward to promote China’s low-carbon city construction.
Chemotherapy-related neurotoxicity in pediatric cancer patients: magnetic resonance imaging and clinical correlation
Authors: Abdou Mo’mena Abdel Aziz , El Kiki Hassan Ali , Madney Youssef , Youssef Ayda Aly 
Published: September 2021

Abstract
Background
Cancer is the second most common cause of death among children aged 1–14 years in the USA. Pediatric malignancies have elevated morbidity and mortality in the absence of proper treatment. Intensive treatment regimens have resulted in a significant increase in the number of survivors but also have been associated with the risk of developing neurotoxicity. The purpose of this study is to emphasize the role of advanced MRI techniques in the early detection of different chemotherapy neurotoxicities and make radiologists aware of them providing early management to prevent permanent damage.

Results
We evaluated 63 patients (43 males and 20 females), and their ages ranged from (2 to 17 years) with suspected chemotherapy-related neurotoxicity. MR examinations were performed with 1.5-T Philips systems. Clinical data were correlated with magnetic resonance imaging (MRI), and different treatment complications were diagnosed. All of our 63 patients were receiving chemotherapy treatment, and they developed different neurological symptoms. Patients diagnosed as posterior reversible encephalopathy syndrome were 41 with 8 patients had typical and 33 had atypical criteria, 16 patients diagnosed as cerebral venous sinus thrombosis with magnetic resonance venography (MRV) are the most important sequence that successfully diagnosed them, and finally, 6 patients diagnosed as methotrexate neurotoxicity with diffusion-weighted images (DWI) are the most important sequence for early diagnosis.

Conclusion
Chemotherapy is associated with certain neurotoxicities, conventional MRI can detect them, but by the use of advanced MRI techniques including MRV and DWI early detection of these neurotoxicities can occur. Therefore, the combination of conventional MRI together with advanced techniques improves the diagnostic efficacy of MRI in the early diagnosis of neurotoxicity.
Aberrant intrathyroidal lymph node metastasis in classical papillary thyroid carcinoma
Authors: Wan Zainon Wan Mohd Nazlee , Wan Abdul Rahman Wan Faiziah , Yahya Maya Mazuwin , Mat Nawi Nor Azwani , Suhaimi Nurul Shamimi , Mat Nawi Norazlina 
Published: September 2021

Abstract
Background
In cases of papillary thyroid carcinoma (PTC), lymph nodes are a typical site of metastasis. Extrathyroidal tissue involvement in differentiated thyroid carcinoma causes the disease to progress and affects the patients’ treatment options. Papillary thyroid carcinoma (PTC) is the common type in differentiated thyroid carcinoma (DTC), the other type is follicular thyroid carcinoma (FTC). Ectopic sites, such as intrathyroidal lymph node invasion in classical papillary thyroid malignancy, are extremely uncommon. It can be difficult to detect an intrathyroidal lymph node (ITLN) during a histopathological test, but it is important to do so since it affects the stage of the disease and subsequent treatment.

Case presentation
We present the case of a 63-year-old woman who presented with multinodular goitre and underwent total thyroidectomy. She was diagnosed with aberrant intrathyroidal lymph node metastases during pathological testing, resulting in an upgrade in treatment. Owing to the exceptionally unusual ectopic position of lymph node metastasis, in this case, there is a risk of diagnostic and therapeutic misinterpretation. This patient was treated with high-dose radioactive iodine in view of lymph node metastases.

Conclusions
Identification of ITLN by imaging characteristics is sometimes difficult, being often an intraoperative discovery and histopathological correlation that lead to upstage the disease and alter the final management.
Financial Burden of Drugs Prescribed for Cancer-Associated Symptoms
Authors: Gupta Arjun , Nshuti Leonce , Grewal Udhayvir S. , Sedhom Ramy , Check Devon K. , Parsons Helen M. , Blaes Anne H. , Virnig Beth A. , Lustberg Maryam B. , Subbiah Ishwaria M. , Nipp Ryan D. , Dy Sydney M. , Dusetzina Stacie B. 
Published: September 2021

PURPOSE: The financial toxicity of anticancer drugs is well-documented, but little is known about the costs of drugs used to manage cancer-associated symptoms. METHODS: We reviewed relevant guidelines and compiled drugs used to manage seven cancer-associated symptoms (anorexia and cachexia, chemotherapy-induced peripheral neuropathy, constipation, diarrhea, exocrine pancreatic insufficiency, cancer-associated fatigue, and chemotherapy-induced nausea and vomiting). Using GoodRx website, we identified the retail price (cash price at retail pharmacies) and lowest price (discounted, best-case scenario of out-of-pocket costs) for patients without insurance for each drug or formulation for a typical fill. We describe lowest prices here. RESULTS: For anorexia and cachexia, costs ranged from $5 US dollars (USD; generic olanzapine or mirtazapine tablets) to $1,156 USD (brand-name dronabinol solution) and varied widely by formulation of the same drug or dosage: for olanzapine 5 mg, $5 USD (generic tablet) to $239 USD (brand-name orally disintegrating tablet). For chemotherapy-induced peripheral neuropathy, costs of duloxetine varied from $12 USD (generic) to $529 USD (brand-name). For constipation, the cost of sennosides or polyethylene glycol was <$15 USD, whereas newer agents such as methylnaltrexone were expensive ($1,001 USD). For diarrhea, the cost of generic loperamide or diphenoxylate-atropine tablets was <$15 USD. For exocrine pancreatic insufficiency, only brand-name formulations were available, range of cost, $1,072 USD-$1,514 USD. For cancer-associated fatigue, the cost of generic dexamethasone or dexmethylphenidate was <$15 USD, whereas brand-name modafinil was more costly ($1,284 USD). For a 4-drug nausea and vomiting prophylaxis regimen, costs ranged from $181 USD to $1,430 USD. CONCLUSION: We highlight the high costs of many symptom control drugs and the wide variation in the costs of these drugs. These findings can guide patient-clinician discussions about cost-effectively managing symptoms, while promoting the use of less expensive formulations when possible.
Early Post-Renal Transplant Hyperglycemia
Authors: Iqbal Anira , Zhou Keren , Kashyap Sangeeta R , Lansang M Cecilia 
Published: September 2021

Abstract

Context
Though posttransplant diabetes mellitus (PTDM, occurring &gt; 45 days after transplantation) and its complications are well described, early post–renal transplant hyperglycemia (EPTH) (&lt; 45 days) similarly puts kidney transplant recipients at risk of infections, rehospitalizations, and graft failure and is not emphasized much in the literature. Proactive screening and management of EPTH is required given these consequences.

Objective
The aim of this article is to promote recognition of early post-renal transplant hyperglycemia, and to summarize available information on its pathophysiology, adverse effects, and management.

Methods
A PubMed search was conducted for “early post–renal transplant hyperglycemia,” “immediate posttransplant hyperglycemia,” “post–renal transplant diabetes,” “renal transplant,” “diabetes,” and combinations of these terms. EPTH is associated with significant complications including acute graft failure, rehospitalizations, cardiovascular events, PTDM, and infections.

Conclusion
Patients with diabetes experience better glycemic control in end-stage renal disease (ESRD), with resurgence of hyperglycemia after kidney transplant. Patients with and without known diabetes are at risk of EPTH. Risk factors include elevated pretransplant fasting glucose, diabetes, glucocorticoids, chronic infections, and posttransplant infections. We find that EPTH increases risk of re-hospitalizations from infections (cytomegalovirus, possibly COVID-19), acute graft rejections, cardiovascular events, and PTDM. It is essential, therefore, to provide diabetes education to patients before discharge. Insulin remains the standard of care while inpatient. Close follow-up after discharge is recommended for insulin adjustment. Some agents like dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists have shown promise. The tenuous kidney function in the early posttransplant period and lack of data limit the use of sodium-glucose cotransporter 2 inhibitors. There is a need for studies assessing noninsulin agents for EPTH to decrease risk of hypoglycemia associated with insulin and long-term complications of EPTH.
Calcitonin Gene Related Peptide, Adrenomedullin, and Adrenomedullin 2 Function in Uterine Artery During Human Pregnancy
Authors: Chauhan Madhu , Betancourt Ancizar , Balakrishnan Meena , Mishra Akansha , Espinosa Jimmy , Shamshirsaz Alireza A , Fox Karin , Belfort Michael , Yallampalli Chandra 
Published: September 2021

AbstractRationaleCalcitonin gene-related peptide (CGRP) and its family members adrenomedullin (ADM) and adrenomedullin 2 (ADM2; also known as intermedin) support vascular adaptions in rat pregnancy.ObjectiveThis study aimed to assess the relaxation response of uterine artery (UA) for CGRP, ADM, and ADM2 in nonpregnant and pregnant women and identify the involved mechanisms.Findings(1) Segments of UA from nonpregnant women that were precontracted with U46619 (1μM) in vitro are insensitive to the hypotensive effects of CGRP, ADM, and ADM2; (2) CGRP, ADM, and ADM2 (0.1-100nM) dose dependently relax UA segments from pregnant women with efficacy for CGRP &gt; ADM = ADM2; (3) the relaxation responses to CGRP, ADM, and ADM2 are differentially affected by the inhibitors of nitric oxide (NO) synthase (L-NAME), adenylyl cyclase (SQ22536), apamin, and charybdotoxin; (4) UA smooth muscle cells (UASMC) express mRNA for calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein (RAMP)1 and RAMP2 but not RAMP3; (5) receptor heterodimer comprising CRLR/RAMP1 and CRLR/RAMP2 but not CRLR/RAMP3 is present in UA; (6) soluble fms-like tyrosine kinase (sFLT-1) and TNF-α treatment decrease the expression of RAMP1 mRNA (P &lt; 0.05) in UASMC; and (7) sFLT-1 treatment impairs the association of CRLR with all 3 peptides while TNF-α inhibits the interaction of CGRP but not ADM or ADM2 with CRLR in UASMC (P &lt; 0.05).ConclusionsRelaxation sensitivity of UA for CGRP, ADM, and ADM2 is increased during pregnancy via peptide-specific involvement of NO system and endothelium-derived hyperpolarizing factors; vascular disruptors such as sFLT-1 and TNFα adversely impact their receptor system in UASMC.
Symmetry, Violence, and The Handmaiden's Queer Colonial Intimacies
Authors: Hu Jasmine 
Published: September 2021

Abstract
The Japanese annexation of Korea (1910–45) implicates a crisis of representation in South Korean national history. Both the traumatic wounds and complex intimacies of Japan's rule over its Korean subjects were met with postcolonial suppression, censorship, and disavowal. This article examines Park Chan-wook's The Handmaiden (Ah-ga-ssi, South Korea, 2016), a period film set in 1930s Korea under Japanese rule, in relation to the two nations’ fraught but interconnected colonial and postcolonial histories. By analyzing the film's explicit sexual depiction through discourses of ethnicity, gender, and nation, it argues that the lesbian sex scenes encode and eroticize latent anxieties and tensions surrounding Japan-Korea relations, making explicit the ambivalent longing and lingering identification shared between the colonizers and the colonized. Furthermore, through intertextual reference to the intertwined and imitative relations between the national cinemas of Japan and Korea—relations mediated and elided by a long history of state censorship—Park's film repudiates an essentialist South Korean identity propped up by both nationalist narratives and market liberalization policies. Through palimpsestic projection of the colonial era onto South Korea's neoliberal present, the film invites parallels between colonialism's unresolved legacy and contemporary modes of cultural production. Simultaneously, the film offers a utopian vision of a national self that surfaces—rather than suppresses—the violence and pleasure incurred in confrontations with the colonial or transnational other.
Daughter of Saul, or Saul Leanya: The Gendered Place of Atrocity in László Nemes's Son of Saul
Authors: Haragos Szidonia 
Published: September 2021

Abstract
László Nemes's 2015 production, Son of Saul (Saul fia), is one of the most critically acclaimed Holocaust movies to date. The film disrupts canonical notions of visual representation of the special squads of Jewish inmates, or Sonderkommando, forced to work in the crematoria. Simultaneously, it radically re-genders an exceptional survival scene recorded as autobiographical truth by witness testimony. A young Hungarian girl's survival of a Zyklon B gassing became exceptional among other incidents of survival in Auschwitz-Birkenau due to the medical assistance offered and the resuscitation administered by the Hungarian medical doctor of the crematoria, Miklos Nyiszli. Son of Saul effectively swaps the body of this teenage girl with the body of a boy in order to re-create a foundational patrilineal story of powerful ideological impact and legitimating force. Pursuing a project of reestablishing a hegemonic male discourse over the Holocaust, the film also portrays a female inmate as one of the four women who made the 7 October 1944 Sonderkommando revolt in Auschwitz-Birkenau possible by smuggling in the explosives for the insurgents. Ella's disconcerting neediness in the film seems uniquely misplaced onto a woman tortured by the Gestapo and hanged without having betrayed her accomplices. While Son of Saul offers its own remarkably successful solutions and modes of cinematic transcendence portraying the ultimate sites of extermination, it does not convey an adequate understanding of gender relations transformed by the historical context of the Final Solution and the vital role of women in the Jewish resistance to the Nazi-orchestrated genocide.
On Carolee
Authors: Rainer Yvonne 
Published: September 2021

Abstract
The essay celebrates Carolee Schneemann, the author's friend and colleague since their first meeting in the early 1960s at Judson Memorial Church, New York. The essay describes the author's and Schneemann's participation in the dance workshops at Judson. The essay cites select works produced by Schneemann at Judson, including Lateral Splay (1962) and Meat Joy (1964). The essay reflects on the relation between the dance workshops and Schneemann's work in painting. It gives particular focus to Schneemann's canonic “solo” Interior Scroll (1975) and the author's experience of the artist's retrospective exhibition Kinetic Painting at MoMA PS1 in 2018. The author presented this essay in the memorial service for Schneemann at Judson Memorial Church on 3 May 2019.