bluuebunny/crossref_metadata_2025_split huggingface dataset:
WOMEN MANAGERS IN AUDITING SECTOR: A DESCRIPTIVE RESEARCH ON TURKEY
Authors: Şengül Çelikay Duygu 
Published: August 2021

This study examines the relationship between female managers' presence in audit firms and audit firms' characteristics. In line with the employment rates obtained from POA, it is observed that gender inequality in the audit sector started from employment. In the research part, 90 audit companies' data that published transparency reports in 2018 were used. It has been determined that there are very few female managers in the sector; in fact, 47 of 90 companies do not have a female partner, board member, or responsible auditor. It is also analyzed that in the older audit firms, the audit firms that earn more revenue and big four firms, the number of female managers is significantly higher than in other firms. The study is essential in revealing that women's employment in the audit sector is a crucial problem and detects the positive relationship between corporate governance and female managers.
Kör Dövüşü Kitap Tanıtımı
Authors: ÇELEBİ Berfu 
Published: August 2021

Ayşen Işık'ın "Kör Dövüşü" adlı öykü kitabında kadın - erkek, kadın - kadın ve kadın - toplum arasındaki çatışma alanları kitaptaki on beş öykünün dil bilimsel açıdan incelenmesi sonucu tespit edilmiştir . Tanıtım yazısında öykülerdeki bu çatışma alanlarına değinilerek kadının varoluşsal mücadelesine değinilmiştir.
Hubungan Perilaku Menjaga Kebersihan Genetalia Eksterna Dengan Penyakit Keputihan
Authors: Dita Ayu , SH Fitri 
Published: July 2021

Berdasarkan data penelitian tentang kesehatan reproduksi wanita menunjukkan 75% wanita di dunia pasti menderita keputihan, paling tidak sekali dalam hidupnya. Perawatan genitalia eksterna yang tidak baik akan menjadi pemicu terjadinya keputihan. Faktanya banyak remaja putri yang belum mengerti dan peduli bagaimana cara merawat organ reproduksinya. Tujuan penelitian ini adalah untuk mengetahui hubungan perilaku menjaga kebersihan genetalia eksterna dengan penyakit keputihan pada siswi SMAN 3 Pangkalpinang Tahun 2016. Metode penelitian ini bersifat survey deskriptif analitik dengan desain cross sectional, penelitian ini dilakukan pada tanggal 26-31 mei 2016, populasi penelitian ini adalah 156 siswi dan jumlah sampel 125 siswi kelas X dan XI SMAN 3 Pangkalpinang Tahun 2016. Pengambilan data dilakukan dengan pengisian kuesioner terpimpin yang telah diuji cobakan, Pengambilan sampel dengan mengunakan kuota sampling dan data analisis secara univariat dan bivariat dengan menggunakan uji chi square dengan derajat kepercayaan 95%. Hasil uji menunjukkan ada hubungan yang bermakna antara perilaku menjaga kebersihan genetalia eksterna dengan penyakit keputihan adalah pengetahuan (p=0,000, POR=6.375), sikap (p=0,000, POR=5.189), tindakan (p=0,001, POR=5.280), hubungan yang paling dominan berhubungan dengan penyakit keputihan adalah pengetahuan (POR: 6,375). Simpulan penelitian adalah ada hubungan yang bermakna antara pegetahuan, sikap dan tindakan menjaga kebersihan genetalia eksterna dengan penyakit keputihan pada siswi SMA Negeri 3 Pangkalpinang. Hubungan yang paling dominan berhubungan yaitu pengetahuan. Diharapkan pihak sekolah saling menjalin kerja sama dengan Instansi Kesehatan dalam mempromosikan pendidikan kesehatan reproduksi dan cara menjaganya.
Effects of Intracoronary Pro-urokinase or Tirofiban on Coronary Flow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction: A Multi-Center, Placebo-Controlled, Single-Blind, Randomized Clinical Trial
Authors: Huang Dong , Qian Juying , Liu Zongjun , Xu Yawei , Zhao Xianxian , Qiao Zengyong , Fang Weiyi , Jiang Li , Hu Wei , Shen Chengxing , Liang Chun , Zhang Qi , Ge Junbo 
Published: August 2021

Background: To determine whether intracoronary pro-urokinase or tirofiban improves myocardial reperfusion during primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI).Methods: The study included patients with acute STEMI presenting within 12 h of symptoms at 11 hospitals in China between November 2015 and July 2017. Patients were randomized to receive selective intracoronary infusion of recombinant pro-urokinase (20 mg), tirofiban (10 μg/kg), or saline (20 mL) proximal to the infarct-related lesion over a 3-min period before stent implantation during primary PCI. The primary outcome was final corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) after PCI.Results: This study included 345 patients. Initial angiography identified a high-grade thrombus (TIMI 4–5) in 80% of patients. Final CTFC after PCI was significantly lower in the pro-urokinase (P &lt; 0.001) and tirofiban (P &lt; 0.001) groups than in the saline group and similar between the pro-urokinase and tirofiban groups (P &gt; 0.05). The pro-urokinase (P = 0.008) and tirofiban groups (P = 0.022) had more complete ST-segment resolution at 2 h and lower peak creatine kinase-MB levels after PCI than the saline group (P = 0.006 and P = 0.023). The 30-day incidence of major adverse cardiac events was 4.5% in the pro-urokinase group, 3.4% in the tirofiban group, and 2.6% in the saline group. The incidence of in-hospital TIMI major bleeding events was low and comparable between groups.Conclusions: Adjunctive intracoronary pro-urokinase or tirofiban given before stent implantation during primary PCI improves myocardial reperfusion without increasing the incidence of major bleeding events.
Fast and Efficient Genome Editing of Human FOXP3+ Regulatory T Cells
Authors: Van Zeebroeck Lauren , Arroyo Hornero Rebeca , Côrte-Real Beatriz F. , Hamad Ibrahim , Meissner Torsten B. , Kleinewietfeld Markus 
Published: August 2021

FOXP3+ regulatory T cells (Tregs) are central for maintaining peripheral tolerance and immune homeostasis. Because of their immunosuppressive characteristics, Tregs are a potential therapeutic target in various diseases such as autoimmunity, transplantation and infectious diseases like COVID-19. Numerous studies are currently exploring the potential of adoptive Treg therapy in different disease settings and novel genome editing techniques like CRISPR/Cas will likely widen possibilities to strengthen its efficacy. However, robust and expeditious protocols for genome editing of human Tregs are limited. Here, we describe a rapid and effective protocol for reaching high genome editing efficiencies in human Tregs without compromising cell integrity, suitable for potential therapeutic applications. By deletion of IL2RA encoding for IL-2 receptor α-chain (CD25) in Tregs, we demonstrated the applicability of the method for downstream functional assays and highlighted the importance for CD25 for in vitro suppressive function of human Tregs. Moreover, deletion of IL6RA (CD126) in human Tregs elicits cytokine unresponsiveness and thus may prevent IL-6-mediated instability of Tregs, making it an attractive target to potentially boost functionality in settings of adoptive Treg therapies to contain overreaching inflammation or autoimmunity. Thus, our rapid and efficient protocol for genome editing in human Tregs may advance possibilities for Treg-based cellular therapies.
Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study
Authors: Liu Jiao , Shen Yanfei , Wen Zhenliang , Xu Qianghong , Wu Zhixiong , Feng Huibin , Li Zhongyi , Dong Xuan , Huang Sisi , Guo Jun , Zhang Lidi , Chen Yizhu , Li Wenzhe , Zhu Wei , Du Hangxiang , Liu Yongan , Wang Tao , Chen Limin , Teboul Jean-Louis , Annane Djillali , Chen Dechang 
Published: August 2021

BackgroundThymosin alpha 1 (Tα1) is widely used to treat patients with COVID-19 in China; however, its efficacy remains unclear. This study aimed to explore the efficacy of Tα1 as a COVID-19 therapy.MethodsWe performed a multicenter cohort study in five tertiary hospitals in the Hubei province of China between December 2019 and March 2020. The patient non-recovery rate was used as the primary outcome.ResultsAll crude outcomes, including non-recovery rate (65/306 vs. 290/1,976, p = 0.003), in-hospital mortality rate (62/306 vs. 271/1,976, p = 0.003), intubation rate (31/306 vs. 106/1,976, p = 0.001), acute respiratory distress syndrome (ARDS) incidence (104/306 vs. 499/1,976, p = 0.001), acute kidney injury (AKI) incidence (26/306 vs. 66/1,976, p &lt; 0.001), and length of intensive care unit (ICU) stay (14.9 ± 12.7 vs. 8.7 ± 8.2 days, p &lt; 0.001), were significantly higher in the Tα1 treatment group. After adjusting for confounding factors, Tα1 use was found to be significantly associated with a higher non-recovery rate than non-Tα1 use (OR 1.5, 95% CI 1.1–2.1, p = 0.028). An increased risk of non-recovery rate associated with Tα1 use was observed in the patient subgroups with maximum sequential organ failure assessment (SOFA) scores ≥2 (OR 2.0, 95%CI 1.4–2.9, p = 0.024), a record of ICU admission (OR 5.4, 95%CI 2.1–14.0, p &lt; 0.001), and lower PaO2/FiO2 values (OR 1.9, 95%CI 1.1–3.4, p = 0.046). Furthermore, later initiation of Tα1 use was associated with a higher non-recovery rate.ConclusionTα1 use in COVID-19 patients was associated with an increased non-recovery rate, especially in those with greater disease severity.
Age- and Gender-Specific Prevalence of Frailty and Its Outcomes in the Longevous Population: The Chinese Longitudinal Healthy Longevity Study
Authors: Wang Huai-yu , Lv Xiaozhen , Du Jian , Kong Guilan , Zhang Luxia 
Published: August 2021

Background: Frailty is an epidemic age-related syndrome addressing heavy burden to the healthcare system. Subject to the rarity, age-, and gender-specific prevalence of frailty and its prognosis among the longevous population remains under-investigated.Methods: Based on the Chinese Longitudinal Healthy Longevity Study (CLHLS, 2008–2018), individuals aged ≥ 65 years having complete data of frailty were recruited. Modified Fried criteria (exhaustion, shrink, weakness, low mobility, and inactivity) were adopted to define pre-frailty (1–2 domains) and frailty (≥3 domains), respectively. The association between pre-frailty/frailty and adverse outcomes (frequent hospitalization, limited physical performance, cognitive decline, multimorbidity, and dependence) was analyzed using logistic regression models. The association between pre-frailty/frailty and mortality was analyzed using Cox proportional hazards models. Age- and gender-stratified analyses were performed.Results: Totally, 13,859 participants aged 85.8 ± 11.1 years, including 2,056 centenarians, were recruited. The overall prevalence of pre-frailty and frailty were 54.1 and 26.3%, respectively. Only 5.0% of centenarians were non-frailty whereas 59.9% of the young-old (65–79 years) showed pre-frailty. Both pre-frailty and frailty were associated with the increased risk of multiple adverse outcomes, such as incident limited physical performance, cognitive decline and dependence, respectively (P &lt; 0.05). Frail males were more vulnerable to the risk of mortality (hazard ratio [HR] = 2.3, 95% confidence interval [CI], 2.1–2.6) compared with frail females (HR = 1.9, 95%CI, 1.7–2.1). The strongest association between frailty and mortality was observed among the young-old (HR = 3.6, 95%CI, 2.8–4.5). Exhaustion was the most common domain among patients with pre-frailty (74.8%) or frailty (83.2%), followed by shrink (32.3%) in pre-frailty and low mobility (83.0%) in frailty. Inactivity among females aged 65–79 years showed the strongest association with the risk of mortality (HR = 3.50, 95%CI, 2.52–4.87).Conclusion: A huge gap exists between longer life and healthy aging in China. According to the age- and gender-specific prevalence and prognosis of frailty, the strategy of frailty prevention and intervention should be further individualized.
Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study
Authors: Huang Yun , Zhang Zeyu , Liao Weijun , Hu Kuan , Wang Zhiming 
Published: August 2021

Background and AimAlthough the treatment effect and availability of therapeutic options for advanced hepatocellular carcinoma (HCC) are limited, the downstaging strategy may improve patient prognosis. This study aimed to investigate the potential of combination therapy as a downstaging strategy for treating advanced HCC with portal vein tumor thrombus (PVTT).MethodsThis retrospective case series included patients having advanced HCC with PVTT, who received the combination therapy of sorafenib, camrelizumab, transcatheter arterial chemoembolization (TACE), and stereotactic body radiation therapy (SBRT) from January 2019 to December 2019 in Xiangya Hospital, Central South University. The downstaging rate, treatment responses, progression-free survival (PFS), overall survival (OS), disease control rate, and toxicities were evaluated.ResultsOf the 13 patients, HCC downstaging was achieved in 4 (33.3%) patients who later received hepatectomy. The overall response rate was 41.7%, and the disease control rate was 50.0%. The median PFS time was 15.7 months, with a 1-year PFS rate of 58.3%, whereas the median OS was not reached after 1 year (1-year OS, 83.3%). No severe adverse events or grade 3–4 adverse effect was observed in 12 of the 13 enrolled patients; therapy had to be discontinued in only one patient due to adverse events, who was excluded from the study. The most common adverse effect was fever (n = 4, 33.3%), followed by skin reaction (n = 3, 25%).ConclusionA combination therapy comprising sorafenib, camrelizumab, TACE, and SBRT is an effective downstaging strategy for advanced HCC with PVTT and is associated with few adverse events.
Predicting the Adult Clinical and Academic Outcomes in Boys With ADHD: A 7- to 10-Year Follow-Up Study in China
Authors: Ren Yanling , Fang Xinyu , Fang Hui , Pang Gaofeng , Cai Jing , Wang Suhong , Ke Xiaoyan 
Published: August 2021

Background: Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood and causes adverse effects on social functioning. The present study aimed to widely investigate the predictors, particularly childhood intelligence quotient (IQ) and family environment factors, on adult clinical and academic outcomes in boys with ADHD.Methods: A total of 101 boys with ADHD in a Chinese Han ADHD cohort were followed up 7–10 years later. Baseline ADHD symptoms were evaluated using the parent version of the ADHD Rating Scale-IV (ADHD-RS-IV) and the Chinese version of the Conners' Parent Rating Scale-Revised (CPRS-48). The intelligence of the child was tested by the China-Wechsler Intelligence Scale for Children (C-WISC), and family function was assessed by the Family Environment Scale-Chinese Edition (FES-CV). Adult ADHD persistence was defined using DSM-IV criteria for ADHD, and academic outcome fell into two categories: higher academic level group (studying in senior middle school or above) and lower academic level group (studying in vocational secondary schools or below).Results: Stepwise multiple logistic regression analysis revealed that the father's character, impulsive–hyperactive index as measured by the CPRS-48, and intellectual–cultural index as measured by the FES-CV independently predicted clinical outcomes in adults, with an AUC of 0.770 (p &lt; 0.001, 95% CI = 0.678–0.863). The corresponding sensitivity and specificity were 0.743 and 0.727, respectively. The father's education level, family economic level, and verbal IQ (VIQ) on the C-WISC independently predicted adult academic outcomes, with an AUC of 0.870 (p &lt; 0.001, 95% CI = 0.796–0.944). The corresponding sensitivity and specificity were 0.813 and 0.783, respectively.Conclusion: Initial ADHD symptom severity and IQ, father's character and education level, and family atmosphere and function affect adult clinical and academic outcomes. Addressing these areas early may help to improve the prognosis of ADHD into adulthood.
The Relationship Between Yoga and Spirituality: A Systematic Review of Empirical Research
Authors: Csala Barbara , Springinsfeld Constanze Maria , Köteles Ferenc 
Published: August 2021

ObjectiveBoth yoga practice and spirituality are associated with beneficial mental health outcomes. Within yoga research, however, spirituality is still a widely neglected area. The present systematic review aims to explore empirical studies, which do, in fact, investigate the relationship between yoga and spirituality in order to provide an overview and future directions for research on this topic. The review examines whether available empirical research supports an association between yoga practice and spirituality and, if so, which specific aspects of spirituality are associated with yoga practice.MethodsThe systematic review followed the PRISMA guideline (Prospero registration number: CRD42020155043). Empirical studies written in English, German, or Hungarian language were selected from a database search in Google Scholar, PsycINFO, and Science Direct. A total of 30 studies met the final inclusion criteria.ResultsAccording to the quantitative and qualitative studies reviewed, yoga practice seems to be positively associated with spirituality. This association concerns various aspects of spirituality, such as spiritual aspirations, a search for insight/wisdom, an integrative worldview, a sense of meaning and peace, faith, hope, compassion, and happiness within. To harness the potential spiritual benefits of yoga, regular practice appears to be essential. Yoga practitioners seem to have both physical and spiritual motives for practicing. At least in Western societies, however, physical intentions are more prevalent than spiritual ones. The meaning of spirituality for yoga practitioners is also discussed. Due to risk of bias of the majority of the reviewed studies, however, outcomes must be taken with caution.ConclusionYoga practice may be positively associated with several aspects of spirituality. For more evidence, further investigation of the topic is suggested. Particularly, we propose the inclusion of holistic forms of yoga practice and a comparison of Eastern and Western approaches to yoga.
Fatores socioeconômicos associados ao rendimento no mercado de trabalho rural no Nordeste / Socioeconomic factors associated with income in the rural labor market in the Northeast
Authors: Ciro Paulo Marcos dos Reis , Albino Pablo Murta Baião 
Published: August 2021

Dada importância do capital humano para o desenvolvimento de um país ou região, cabe salientar a diversidade regional brasileira no que tange ao mercado de trabalho rural. A região do Nordeste conta com metade da população ocupada em atividades agrícolas e apresenta fatores socioeconômicos insatisfatórios comparando com as demais regiões. Neste sentido, a presente pesquisa buscou identificar os fatores associados ao mercado de trabalho rural no Brasil e especificamente, para a região do Nordeste. O trabalho tem como hipótese central a especificidade do Nordeste rural, em especial a baixa escolaridade, afeta negatividade os rendimentos. Para isso, utilizou os microdados da Pesquisa Nacional por Amostra de Domicílios (PNAD) de 2004 a 2012. Empregando o método de pseudo painel, utilizando coortes de idade, sexo e raça, para reduzir o possível viés dos estimadores decorrente do problema de endogeneidade entre rendimento e escolaridade. Os resultados mostraram que o retorno à educação no Nordeste é inferior às demais regiões do país, confirmando as expectativas iniciais. Ainda, cabe salientar as especificidades de cada Estado que compõe esta região. Por fim, conclui-se que, dadas as diferenças de dinâmica do mercado de trabalho do Nordeste, além de outras especificidades de outras naturezas, é importante que pesquisas futuras e políticas públicas levem em consideração as particularidades da região.
Peran Gereja dalam Memberdayakan Penyandang Disabilitas di Gereja Toraja Jemaat Kaero
Authors: Devi Devi , Ivan Ivan , Rumbi Frans Paillin 
Published: July 2021

Abstract : This paper explains congregation understanding about people with disabilities and how the church empowers them. This paper using a qualitative method with the inductive approach—data sources from literature research, observations, and interviews. The findings of this research are people with disabilities were very difficult to accept the situation. However, the people with disabilities can rise and think positively after getting mentoring from church. Chruch assembly to organize service programs like material help and pastoral care, and then empowers. Now, people with disabilities will be getting self-sufficient and participate in serving the church.

Keywords: service, church, empowerment, and disability

Abstrak : Tulisan ini bermaksud menjelaskan pemahaman jemat tentang penyandang disabilitas serta bagaimana gereja memberdayakan para penyandang disabilitas. Data-data dikumpulkan melalui studi kepustakan, observasi dan wawancara. Hasil penelitian ini menemukan bahwa penyandang disabilitas awalnya sulit untuk menerima keadaannya. Akan tetapi mereka dapat bangkit dan berpikir positif karena mendapat pendampingan dari gereja. Majelis gereja menggiatkan program diakonia baik berupa bantuan materi, pendampingan pastoral dan pemberdayaan. Kini penyandang disabilitas mulai menjadi pribadi yang mandiri dan terlibat aktif dalam pelayanan.

Kata kunci: Diakonia, Gereja, Pemberdayaan dan Penyandang Disabilitas
SYMBOLIC STRUGGLE FOR POLICY IMPLEMENTATION OF «ACTIVE AGING» IN THE RUSSIAN SOCIAL AND LABOR SPHERE
Authors: Сизова И. Л. , Орлова Н. С. 
Published: August 2021

В статье рассматриваются социальные процессы, сопровождающие реализацию политики «активного долголетия» в российской социальнотрудовой сфере. В первом разделе статьи кратко представляются основы концепции «активного долголетия» и обсуждаются возможные социальные механизмы ее применения. Особое место здесь отводится анализу социальных прав, которые формируют основу для разных моделей развития общественного благосостояния и качества жизни населения. Во втором разделе на базе парадигмы конструктивизма в социальных науках и теории символической власти П. Бурдьё предлагается авторский вариант изучения структур восприятия и оценивания населением реализованных государственных реформ. В третьем разделе представлены результаты эмпирического анализа серии полуструктурированных интервью с основными субъектами социально-трудовой сферы и текстов обращений граждан в органы государственной власти. В заключение интерпретируется символическая борьба вокруг восприятия политики «активного долголетия» в России. Авторы приходят к выводу о том, что ожидается новый всплеск программ социальной помощи пожилым и рост пассивности в их трудовом поведении.
The article examines the social processes accompanying implementation of the policy «active aging» in the Russian social and labor spheres. The basic concepts of «active aging» are brieﬂ y introduced and possible social mechanisms of its application are discussed in the ﬁrst section of the article. Special importance is given to the analysis of social rights which form the basis for different models of the development of public welfare and the population’s quality of life. In the second section, author’s version of studying the perception and assessment structures by the population of the implemented reforms of the State are proposed on the basis of the paradigm of constructivism in the social sciences and the theory of symbolic power by P. Bourdieu. In the third section the results of an empirical analysis of a set of semi-structured interviews with the main subjects of the social and labor spheres and the texts of citizens’ appeals to government bodies are presented. In conclusion, the symbolic struggle around the perception of the «active aging» policy in Russia is interpreted. The authors conclude that a new surge in social assistance programs for the elderly and an increase in passivity in their work behavior are expected.