bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between systemic immune inflammation index and newly diagnosed adult celiac disease
Authors: Cakir Isil , Dogan Serkan 
Published: September 2021

Abstract

Objectives
The systemic immune inflammation index (SII) is a novel biomarker based on platelet, neutrophil and lymphocyte counts. SII serum levels have diagnostic, prognostic degrees and correlations with various immune, inflammatory diseases. Celiac disease (CD) is an immune-mediated chronic enteropathy with inflammatory situations. Here we aimed to evaluate clinical significance of SII and to compare SII with other inflammatory markers in CD.

Methods
161 pathologically confirmed CD and 75 dyspeptic patients were enrolled. Hemogram, biochemical markers, SII, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume-to-platelet ratio (MPR) and monocyte-to-high density lipoprotein cholesterol ratio (MHR) were evaluated.

Results
There was a statistically significant difference between groups for SII (p<0.001). SII was statistically correlated with and superior to inflammatory markers in relation with CD. There were also statistically significant differences between groups for hsCRP, PLR, NLR, MPR, haemoglobin, platelet count, platelet volume distribution width, plateletcrit, ferritin, total cholesterol and HDL cholesterol (p=0.034; 0.015; 0.032; <0.001; <0.001; <0.001; 0.030; 0.001; <0.001; <0.001; 0.048, respectively). Correlations between SII and NLR, PLR, MHR, hsCRP were statistically significant (p≤0.001; <0.001; 0.033; 0.030, respectively). ROC analysis was used to determine the optimal cut-off value for CD by SII. A baseline SII level >560.0 was associated with CD with 64% specificity, 78% sensitivity (p<0.001).

Conclusions
To the best of our knowledge, this is the first study analyzed the diagnostic value of SII in CD. SII may serve as a beneficial marker for the diagnosis of inflammatory state superior to that of hsCRP, PLR, NLR, MHR, MPR and WBC.
miR-485-5p alleviates Alzheimer’s disease progression by targeting PACS1
Authors: He Chuan , Su Caixia , Zhang Wentong , Wan Qi 
Published: September 2021

Abstract
Alzheimer’s disease (AD) is a common dementia and a heterogeneous disease. Previous research has validated that microRNAs (miRNAs) are pivotal regulators in the initiation and development of tremendous diseases including AD. MicroRNA-485-5p (miR-485-5p) was reported to be an important participant implicated in several neurological diseases, but its role in AD still needs to be further investigated. In this research, we explored the biological function of miR-485-5p in AD. RT-qPCR revealed that miR-485-5p expression was downregulated in the hippocampus of APP/PS1 mice. Additionally, miR-485-5p overexpression facilitated the learning and memory capabilities of APP/PS1 mice according to Morris water maze test, fear conditioning test, and immunofluorescent staining. Moreover, CCK-8 assay, flow cytometric analysis, and western blot analysis suggested that miR-485-5p overexpression promoted pericyte viability and prohibited pericyte apoptosis in APP/PS1 mice. Mechanistically, miR-485-5p directly targeted PACS1 in pericytes, as shown in a luciferase reporter assay. In rescue assays, PACS1 overexpression countervailed the effect of miR-485-5p overexpression on pericyte viability and apoptosis. In conclusion, miR-485-5p ameliorates AD progression by targeting PACS1.
Nonlinear excitations and dynamic features of dust ion-acoustic waves in a magnetized electron–positron–ion plasma
Authors: Maity Rabindranath , Sahu Biswajit 
Published: September 2021

Abstract
A wide class of nonlinear excitations and the dynamics of wave groups of finite amplitude ion-acoustic waves are investigated in multicomponent magnetized plasma system comprising warm ions, and superthermal electrons as well as positrons in presence of negatively charged impurities or dust particles. Employing the reductive perturbation technique (RPT), the Korteweg–de-Vries (KdV) equation, and extended KdV equation are derived. The presence of excess superthermal electrons as well as positrons and other plasma parameters are shown to influence the characteristics of both compressive and rarefactive solitons as well as double layers (DLs). Also, we extend our investigation by deriving the nonlinear Schrödinger equation from the extended KdV equation employing a suitable transformation to study the wave group dynamics for long waves. The analytical and numerical simulation results demonstrate that nonlinear wave predicts solitons, “table-top” solitons, DLs, bipolar structure, rogue waves, and breather structures. Moreover, implementing the concept of dynamical systems, phase portraits of nonlinear periodic, homoclinic trajectories, and supernonlinear periodic trajectories are presented through numerical simulation.
Effect of Thermal-Oxygen Aging on Temperature Stability of Styrene-Butadiene-Styrene–Modified Asphalt
Authors: Wang Lan , Xue Zhihua , Zhang Le 
Published: September 2021

Abstract
In order to explore the effect of aging on the temperature stability of styrene-butadiene-styrene (SBS)-modified asphalt, matrix asphalt and SBS-modified asphalt were used as the control to conduct short-term aging and long-term aging. Three indexes of asphalt with different aging degrees were tested to analyze the change rule of each index. The specific heat capacity and phase transition temperature of SBS-modified asphalt before and after aging were studied by differential scanning calorimetry (DSC). At last, the mechanism was studied by attenuated total reflection Fourier infrared spectroscopy. The results show that the penetration and ductility of matrix asphalt and SBS-modified asphalt decrease with the deepening of aging. The difference is that the softening point of matrix asphalt shows an increasing trend, whereas the softening point of SBS-modified asphalt shows a changing rule of first decreasing and then rising. The addition of SBS modifier can increase the specific heat capacity of asphalt and change the viscosity-flow conversion temperature. The degradation of SBS modifier leads to the decrease of the specific heat capacity after long-term aging, whereas the viscosity-flow conversion temperature decreases first and then rises, which is consistent with the change law of softening point. As a special block copolymer, the specific heat capacity of SBS modifier is determined by the polymer butadiene with lower glass transition temperature, whereas the softening point changes with the polymer styrene with higher glass transition temperature, which is consistent with the change rule of functional group index, softening point, and specific heat capacity of SBS-modified asphalt before and after aging.
Analysis of the Effects of Voids in Mineral Aggregate on Pavement Fatigue Performance Using AASHTOWare Pavement ME Design and FlexPAVE
Authors: Mirzahosseini Mohammadreza , Lee Jusang , Olek Jan , Jeon Jongmyung , Nantung Tommy E. 
Published: September 2021

Abstract
Deviation of volumetric properties of asphalt mixtures, such as voids in mineral aggregates (VMA), from the agency–specified thresholds can cause minor to significant changes in pavement performance. This paper presents the results of the study on the effects of the deficiency of VMA parameters (ΔVMADesign) on the fatigue performance of asphalt pavements. Dynamic modulus and fatigue tests were performed on two types of mixtures (one with 9.5-mm nominal maximum aggregate size (NMAS) and the second one with 19-mm NMAS) at three levels of ΔVMADesign. The results were analyzed using two simulation models (i.e., FlexPAVE 1.1Alpha and AASHTOWare Pavement ME Design version 2.3.0 (Pavement ME)). The results showed that fatigue service life reduction was linearly correlated to an increase in ΔVMADesign and could reach almost 50 % for a pavement with ΔVMADesign of 3 %. Additionally, while both Pavement ME and FlexPAVE showed comparable results in terms of top-down cracking/damage predictions, the results of the analysis performed by FlexPAVE in terms of bottom-up damage prediction were more consistent with respect to the expected behavior of pavement structure in terms of damage.
Thyroid autoimmunity and metabolic syndrome: a nationwide population-based study
Authors: Kim Hye Jeong , Park Sang Joon , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil , Yoo Myung Hi 
Published: September 2021

Objective
Recent studies have reported that thyroid hormone levels are associated with metabolic syndrome (MetS) even in euthyroid subjects. However, the association between thyroid autoimmunity and MetS is uncertain. This study aimed to investigate the relationship between thyroid autoimmunity and MetS in a large cohort study of euthyroid subjects.

Methods
A total of 4775 participants aged ≥19 years from the Korea National Health and Nutrition Examination Survey VI (2013–2015) with anti-thyroid peroxidase antibody (TPOAb) results and normal thyroid functions were included in this study. Subjects were grouped according to thyroid autoimmunity (positivity of TPOAb). We estimated the odds ratios (ORs) for MetS according to TPOAb positivity using logistic regression models, adjusted for potential confounders.

Results
Of the study subjects, 25% (n = 1206) were diagnosed with MetS. Subjects with MetS showed higher median TPOAb levels (6.3 vs 6.8 IU/mL, P < 0.001) and higher positivity of TPOAb (5 vs 7%, P = 0.002) than those without MetS. There was a significant difference in prevalence of MetS depending on the TPOAb positivity (25% vs 33%, P = 0.002). Subjects with TPOAb positive had a significantly greater risk of abdominal obesity (OR 1.675, 95% CI: 1.302–2.154, P < 0.001), low high-density lipoprotein cholesterol (OR: 1.603, 95% CI: 1.244–2.066, P < 0.001) and elevated blood pressure (OR: 1.418, 95% CI: 1.099–1.829, P = 0.007) as compared to those with TPOAb negative. Positivity of TPOAb was a significant risk factor for MetS even after adjusting for confounding variables including age, sex, household income, education, smoking, alcohol consumption, walking activity, thyroid-stimulating hormone and free thyroxine (OR: 1.389, 95% CI: 1.048–1.841, P = 0.022).

Conclusion
In euthyroid subjects, thyroid autoimmunity is associated with MetS. Further large longitudinal studies are needed to clarify causality.
Education and the Postmodern Subject in Neoliberal Society and the Possibilities of Emancipation by Paulo Freire’s Pedagogy
Authors: Zanatta Ronnie Peter Pereira , Dias Maria Sara Lima , Saavedra Filho Nestor Cortez 
Published: September 2021

Background: In a society increasingly marked by the logic of contemporary capitalism, education becomes an instrument for the reproduction of alienated labour forces. Objectives: To provide an overview of the characteristics of subjectivity and attitudes of the postmodern subject based on the studies of Fredric Jameson and David Harvey; unveiling the development of techniques for producing more effective ways of subjecting the company culture to neoliberal rationality described by Pierre Dardot and Christian Laval and their influences on the formation of contemporary identities; reflect on the role of education, in particular of scientific education, in overcoming the state of alienation brought about by the capitalist system of neoliberal societies. Design: Articulation between exploratory and bibliographic research, articulated with the theoretical frameworks of Paulo Freire’s critical theory and pedagogy. Settings and Participants: Given the typology of the research carried out, articles, books and documents about the capitalist system in neoliberal societies, the educational legislation and Paulo Freire’s pedagogy. Data Collection and analysis: Critical reflection on the texts consulted and included in the research. Results: There is a relationship between the subjects constituted from the marketing logic and the role of the school as a reproducer of mechanisms of subjugation to the hegemonic capitalist system; there is also the business and industrial influence in the development of educational policies throughout the history of education. Conclusions: As a possibility of transforming this scenario of alienation from the educational system to hegemonic power, the Freirean conception of emancipatory critical humanist education is presented, in addition to the reproduction of capitalist logic, based on the awareness of subjects based on dialogical pedagogy and the appropriation of the scientific knowledge as a transformer of reality.
Az adat és a kormányzás jelentősége az okos város stratégiai alapú értékteremtési folyamatában – Magyar nagyvárosok összehasonlítása egy szintetizáló ökoszisztéma modell keretében
Authors: Gyimesi Áron , Somlyódyné Pfeil Edit 
Published: September 2021

Álláspontunk szerint az okos város az embert helyezi a középpontba, a technológia csupán a lehetőséget biztosítja arra, hogy a városok élhetőbbek, innovatívabbak legyenek, hatékonyabban működjenek, és jobban megállják a helyüket a polgárokért vívott versenyben. A városok digitális átalakulása azonban tudatos stratégia mentén, a kijelölt prioritások betartásával, kizárólag akkurátus megvalósítással lehet sikeres. Tanulmányunkban sorra vesszük az okos várossá válás tekintetében meghatározó tényezőket. Elemezzük az okos várossá válás lehetséges fókuszpontjait, illetve megrajzoljuk azokat az összefüggéseket, amelyek valóban komplex kihívássá teszik az átalakulás folyamatát. Értékeljük a mért adat kiemelt helyét az okosváros-koncepcióban, és azonosítjuk az e-government fogalmát, valamint az okos kormányzás városvezetési módszertanát, mint az okos várossá válás értékteremtő irányítási metódusát. Úgy véljük, hogy ez a két tényező kiemelt fontosságú: ezek tartják fent a kapcsolatot az okos város megannyi koncepcionális alkotóeleme között, amelyeket egy, a céljai szerint szintetizáló, az elméleti és a pragmatikus okos város stratégiai modelleket egyesítő új ökoszisztéma modell keretei között jelenítünk meg. A modell alapgondolata szerint az okos várost egyfajta platformként képzeljük el, amelynek dinamikusan áramoltatnia kell az információkat és a feladatokat, átlépve a város hagyományos ágazatai között; egyszerre kielégítve a speciális ügykezelési szempontokat és a komplexebb kormányzásra vonatkozó igényeket. A modell integrálja, dinamizálja és fejlődésre sarkallja az okos város külső és belső szereplőit, strukturális és koncepcionális elemeit, valamint operatív testületeit és technológiai megoldásait.
A modellt egy olyan kutatás eredményeként jelenítjük meg, amely során öt magyarországi nagyváros okos város stratégiai dokumentumainak szemantikai elemzését valósítottuk meg. A stratégiai dokumentumok elemzése során elsődlegesen arra a kérdésre kerestük a választ, vajon a szakirodalom által rendszerezett okosváros-jellemzők, struktúrák megjelennek-e ezekben a dokumentumokban. Kerestük továbbá az elméleti munkákban dominánsan megjelenő ágazati megközelítéssel szakító modellünk visszaigazolását. A tanulmányunk törekvése, hogy egyensúlyt találjon az okosváros-paradigma komplex rendszerében, miközben rávilágít azokra a dinamikus elemi és absztrakt tényezőkre, amelyek annak motorjául szolgálnak.
Miller Fisher syndrome developed after a previous COVID-19 infection (case report)
Authors: Malko V. A. , Klimov P. V. , Topuzova M. P. , Yarush I.  V. , Simakov K. V. , Alekseeva T. M. 
Published: September 2021

Miller Fisher syndrome is one of the forms of Guillain–Barrе́ syndrome, characterized by a clinical triad that includes ophthalmoplegia, ataxia and areflexia, with the possible addition of moderate peripheral tetraparesis. During the year that has passed since the start of the pandemic of the new coronavirus infection COVID‑19, international publications have presented a few cases of Miller Fisher syndrome, which developed in patients at different times after the COVID‑19 infection – from 3–5 days to 3 weeks. The article presents a description of a clinical case of Miller Fisher syndrome, which occurred with 34‑year‑old man 21 days after the COVID‑19 infection. The clinical manifestations of Miller Fisher syndrome were typical and included diplopia, areflexia, and ataxia. At the beginning of the disease, there was a transient episode of speech impairment in the form of mild dysarthria. Oculomotor disorders predominated in the clinical picture over other components of the classical triad. On the background of treatment with human immunoglobulin G, there was a complete regression of symptoms.This description of Miller Fisher syndrome, which developed after the postponed infection with COVID‑19, is the first in Russia. The presented case demonstrates the ability of the SARS‑CoV‑2 virus to induce the development of an autoimmune disease. Practitioners should take into account the possibility of Miller Fisher syndrome developing in the event of an acute onset of diplopia, ataxia and areflexia in patients after a previous COVID‑19 infection.
Survey of Fragile Geologic Features and Their Quasi-Static Earthquake Ground-Motion Constraints, Southern Oregon
Authors: McPhillips Devin , Scharer Katherine M. 
Published: September 2021

ABSTRACTFragile geologic features (FGFs), which are extant on the landscape but vulnerable to earthquake ground shaking, may provide geological constraints on the intensity of prior shaking. These empirical constraints are particularly important in regions such as the Pacific Northwest that have not experienced a megathrust earthquake in written history. Here, we describe our field survey of FGFs in southern Oregon. We documented 58 features with fragile geometric characteristics, as determined from field measurements of size and strength, historical photographs, and light detection and ranging point clouds. Among the surveyed FGFs, sea stacks have particular advantages for use as ground-motion constraints: (1) they are frequently tall and thin; (2) they are widely distributed parallel to the coast, proximal to the trench and the likely megathrust rupture surface; and (3) they are formed by sea cliff retreat, meaning that their ages may be coarsely estimated as a function of distance from the coast. About 40% of the surveyed sea stacks appear to have survived multiple Cascadia megathrust earthquakes. Using a quasi-static analysis, we estimate the minimum horizontal ground accelerations that could fracture the rock pillars. We provide context for the quasi-static results by comparing them with predictions from kinematic simulations and ground-motion prediction equations. Among the sea stacks old enough to have survived multiple megathrust earthquakes (n = 16), eight yield breaking accelerations lower than the predictions, although they generally overlap within uncertainty. FGFs with the lowest breaking accelerations are distributed uniformly over 130 km of coastline. Results for inland features, such as speleothems, are in close agreement with the predictions. We conclude that FGFs show promise for investigating both past earthquake shaking and its spatial variability along the coasts of Oregon and Washington, where sea stacks are often prevalent. Future work can refine our understanding of FGF age and evolution.
Multichannel Alignment of S Waves
Authors: Bostock Michael , Plourde Alexandre , Drolet Doriane , Littel Geena 
Published: September 2021

ABSTRACT
High-resolution earthquake locations and structural inversions using body waves rely on precise delay-time measurements. Subsample accuracy can be realized for P waves using multichannel cross correlation (MCCC), as developed by VanDecar and Crosson (1990), which exploits redundancy in pairwise cross correlations to determine delays between similar waveforms in studies of mantle structure using teleseismic sources (common source and multiple stations) and regional studies of structure and seismicity (multiple sources and common station). For regional S waves, alignment is complicated by the additional degree of freedom in waveform polarity that is expressed for sources with different moment tensors. Here, we recast MCCC within a principal component framework and demonstrate the equivalence between maximizing waveform correlation and minimization of various singular value–based objective functions for P waves. The singular-value framework is more general and leads naturally to an MCCC linear system for S waves that possesses an order of magnitude greater redundancy than that for P waves. Robust L1 solution of the system provides an effective means of mitigating outliers at the expense of subsample precision. Residual time shifts associated with higher-order singular vectors are employed in an iterative adaptive alignment that achieves subsample resolution. We demonstrate application of the approach on a seismicity cluster within the northern Cascadia crustal fore-arc.
Rayleigh Wave Propagation in the Bighorn Mountains Region, Wyoming
Authors: Kintner Jonas A. , Cleveland K. Michael , Modrak Ryan , Dunham Audrey 
Published: September 2021

ABSTRACT
Short-period Rayleigh waves, Rg, provide strong constraints on the depth of shallow seismic events and are of interest for monitoring small explosions. Characterizing the seismic sources that generate Rg requires an understanding of how shallow crustal structure affects Rayleigh wave propagation. In support of these efforts, this study utilizes observed waveforms from small shallow explosions recorded on temporary seismic network deployments in the Bighorn region, Wyoming. We study regional near-surface geology by measuring changes in surface-wave amplitude and polarization during propagation through basins, foothills, and mountains. We develop additional insight by carrying out surface-wave eigenfunction analyses and numerical-wave simulations, which together reproduce many characteristics seen in the observed waveforms. Our results show how sedimentary basins in the Bighorn region allow for amplified prograde-polarized higher-mode and retrograde-polarized fundamental-mode Rayleigh waves, whereas adjacent mountains only support retrograde motion. These different modes provide distinct constraints on the Earth structure and source characteristics, potentially enabling targeted inversions in future studies. Our findings provide insight into Rg propagation through complex near-surface geology, improving our understanding of shallow propagation and source effects that are relevant to explosion monitoring efforts.
ETAS-Approach Accounting for Short-Term Incompleteness of Earthquake Catalogs
Authors: Hainzl Sebastian 
Published: September 2021

ABSTRACT
The epidemic-type aftershock sequence (ETAS) model is a powerful statistical model to explain and forecast the spatiotemporal evolution of seismicity. However, its parameter estimation can be strongly biased by catalog deficiencies, particularly short-term incompleteness related to missing events in phases of high-seismic activity. Recent studies have shown that these short-term fluctuations of the completeness magnitude can be explained by the blindness of detection algorithms after earthquakes, preventing the detection of events with a smaller magnitude. Based on this assumption, I derive a direct relation between the true and detectable seismicity rate and magnitude distributions, respectively. These relations only include one additional parameter, the so-called blind time Tb, and lead to a closed-form maximum-likelihood formulation to estimate the ETAS parameters directly accounting for varying completeness. Tests using synthetic simulations show that the true parameters can be resolved from incomplete catalogs. Finally, I apply the new model to California’s most prominent mainshock–aftershock sequences in the last decades. The results show that the model leads to superior fits with Tb decreasing with time, indicating improved detection algorithms. The estimated parameters significantly differ from the estimation with the standard approach, indicating higher b-values and larger trigger potentials than previously thought.