bluuebunny/crossref_metadata_2025_split huggingface dataset:
DOCK4 Correlated with Immune Infiltration is a Valuable Prognostic Biomarker in Stomach Adenocarcinoma.
Authors: Lu Yi , Yu Xi Jia , Dong Ping Qiu , Du Yan , Liang Zheng 
Published: November 2021

Abstract
Background:Dedicator for cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) for the small GTPase Rac1, the mechanisms involved in immune infiltration in STAD (stomachadenocarcinoma) remain unclear. Methods: The UALCAN database was used to analyze the expression of the DOCKfamily, and the Kaplan-Meier plotter and GEPIA databases were used to assess the prognostic value of the DOCK family in STAD. Furthermore,the correlation between DOCK4 expression withtumor immune infiltration and the expression of related immune marker genes in STAD was explored using TIMER and GEPIA websites. Subsequently, the relationship between DOCK4 expression and clinical characteristics was verified using the UALCAN database. Finally, the mutation of DOCK4 was analyzed via TIMER2.0 and cBioPortal databases. And the protein-protein interaction(PPI) networks of DOCK4 were constructed using GeneMANIA and STRING websites.Results: DOCK4 was finally screened out, and its expression in tumors was significantly evaluated relative to paracancerous tissues and had a negative impact on the prognosis of patients with STAD.DOCK4 was found significantly related to tumor immune infiltration in STAD.Conclusions:In summary, DOCK4 is a potential regulator of the recruitment and regulation of immune infiltrating cells, thus becoming a valuable prognosticbiomarker in STAD.
The COVID-19 Pandemic Highlights An Unmet Need To Improve Remote Assessment of Disease Activity in Rare Diseases, Juvenile-Onset Systemic Lupus Erythematosus And Juvenile Dermatomyositis
Authors: Peng Junjie , Mehta Puja , Khatun Ayesha , Wu Wing-Han , Hennelly Laura , Doolan Georgia , Henty Julian Robert , Howard Paul , Jury Elizabeth C , Ciurtin Coziana 
Published: November 2021

Abstract
Here we report the results of a pilot young patient survey which targeted patients with juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM), which explored wellbeing, resilience and general concern about the COVID-19 pandemic. The survey was completed anonymously by patients who have been approached via the automatically generated hospital data base between June-December 2020. This pilot study found that generalised concerns regarding the COVID-19 pandemic were significantly higher in females, although their self-reported disease activity scores were comparable with male respondents. Our findings highlight a need to improve remote assessments to facilitate triaging for face-to-face visits in the situation of future pandemics associated with disruption of clinical services, as well as further research in this area of young patient-reported outcomes outside hospital visits.
Quantitative Evaluation of Disease Severity in Connective Tissue Disease-associated Interstitial Lung Disease by Dual-energy Computed Tomography
Authors: Chen Ling , Lu Haiyan , Zhu Min , Yang Ting , Li WanJiang , Zhang Yali , Xie Qibin , Li Zhenlin , Wan Huajing , Luo Fengming 
Published: November 2021

Abstract
BACKGROUND: High-resolution computed tomography (HRCT) is recommended for diagnosing and monitoring connective tissue disease-associated interstitial lung disease (CTD-ILD). Quantitative computed tomography has the potential to precisely assess the radiological severity of CTD-ILD, but has still been under study.OBJECTIVE: To investigate whether dual-energy computed tomography (DECT), a novel quantitative technique, can be used in the quantitative severity assessment in CTD-ILD. METHODS: This cross-section study recruited adult CTD-ILD patients who underwent a DECT scan from the ICE study between October 2019 and April 2021. DECT parameters, including effective atomic number (Zeff), volume, and monochromatic CT number (MCTN) of each lung lobe, were evaluated. CTD-ILD was classified into extensive CTD-ILD and limited CTD-ILD by staging algorithm combined pulmonary function test (PFT) and total extent of ILD (TEI) score based on the chest CT. Dyspnea, cough, and life quality were scored by Borg dyspnea score, Leicester cough questionnaire (LCQ), and short-form 36 health survey questionnaire (SF-36), respectively. RESULTS: There was a total of 121 CTD-ILD patients enrolled. Higher Zeff value (3.11 vs 2.26, p < 0.001), higher MCTN (-721.31 vs -801.44, p < 0.001), and lower lung volume (2481.13cm3 vs 3525.52cm3, p < 0.001) were found in extensive CTD-ILD compared with limited CTD-ILD. DECT parameters had a moderate to high correlation with FVC%pre (|r| = 0.647-0.750, p < 0.01) and DLCO%pre (|r| = 0.424-0.484, p < 0.01), and moderate to high correlation with TEI (|r| = 0.411-0.719, p < 0.01). Receiver operating characteristic (ROC) analysis suggested MCTN had the best performance for extensive CTD-ILD discrimination in right middle lung lobe (AUC = 0.877, cut-off: -805, p < 0.001), with a sensitivity of 86.36% and a specificity of 77.42%. The Zeff value was the independent risk factor for dyspnea and cough ( OR = 3.716 for dyspnea, p < 0.05; OR = 2.294 for cough, p < 0.05), and lung volume significantly contributed to the mental component summary (MCS) in SF-36 (β=0.190, p < 0.05).CONCLUSIONS: DECT parameters can be applied to evaluate the severity of CTD-ILD.
Unraveling the Structure and Role of Mn and Ce for Selective Catalytic Reduction of NOx in Application-Relevant Catalysts and Conditions
Authors: Gevers Lieven , Enakonda Linga , Shahid Ameen , Ould-Chikh Samy , Paalanen Pasi , Hedhili Mohamed , Wen Fei , Ruiz-Martinez Javier 
Published: November 2021

Abstract
Mn-based oxides are promising catalysts for the selective catalytic reduction (SCR) of NOx with NH3 at temperatures below 200 °C. There is a general agreement that combining Mn with another metal oxide, such as CeOx improves catalytic activity. However, to date, there is an unsettling debate on the role of Ce as Mn promoter on the SCR reaction. To solve this, here we have systematically studied the effect Ce by preparing, characterizing and testing around 30 catalysts aiming for a well-controlled homogeneous dispersion of the metal oxides. Our results show that, at low-temperature SCR conditions, the intrinsic activity of the Mn active sites is not positively affected by Ce species in intimate contact. In fact, the results suggest that Ce is electronically interacting with Mn and decreasing the active-site average activity. To confirm our findings, activities reported in literature were surface-area normalized and the analysis do not support an increase in activity by Ce addition. Therefore, we can unequivocally conclude that the beneficial effect of Ce is textural, increasing catalyst surface area and therefore the total number of active sites. Besides, addition of Ce is increasing N2 selectivity as it suppresses second-step oxidation reactions and thus N2O formation by structurally diluting the MnOx active sites. Therefore, the textural promoting effect still makes Ce an interesting additive for Mn catalysts.
Title MiR-188-5p Affects the Progression of Alzheimer's disease by Negatively Regulating Neuritin Expression
Authors: Sun Jiawei , Song Dandan , song yin , Li Guoxiang , Meng Pingping , Zhu Jingling , Huang Jin 
Published: November 2021

Abstract
BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disease characterized by complex pathobiological characteristics and still lacks accurate biomarkers in early diagnosis. Neuritin (NRN1) is a neurotrophic factor, which has active roles in neuronal plasticity and regeneration. Recent research suggests that Neuritin has been associated with loss of cognitive function, maybe a potential therapeutic target in AD. MethodsWe have clustered the upregulated miRNAs in AD and predicted the target miRNAs of Neuritin by bioinformatics analysis, found miR-188-5p may involve in the development of AD. ResultsIn the present study, we confirm the association between Neuritin and miR-188-5p expression in mice with AD. Besides, we provide evidence for the changes of cognition capacity, miR-188-5p and Neuritin levels in APP/PS1 mice. ConclusionOur results reveal a previously undefined mechanism that miR-188-5p plays a significant role in the development of AD by inhibiting the expression of target protein Neuritin.
Progression of Aortic Dissection: An Application of Soliton Solutions of Nonlinear Evolution Equation in (3+1)-Dimensions
Authors: JADAUN VISHAKHA , Singh Nitin 
Published: November 2021

Abstract
Aortic dissection is a serious pathology involving the vessel wall of the aorta with significant societal impact. To understand aortic dissection we explain the role of the dynamic pathology in the absence or presence of structural and/or functional abnormalities. We frame a differential equation to evaluate the impact of mean blood pressure on the aortic wall and prove the existence and uniqueness of its solution for homeostatic recoil and relaxation for infinitesimal aortic tissue. We model and analyze generalized (3+1)-dimensional nonlinear partial differential equation for aortic wave dynamics. We use the Lie group of transformations on this nonlinear evolution equation to obtain invariant solutions, traveling wave solutions including solitons. We find that abnormalities in the dynamic pathology of aortic dissection act as triggers for the progression of disease in early-stage through the formation of soliton-like pulses and their interaction. We address the role of unstable wavefields in waveform dynamics when waves are unidirectional. Moreover, the notion of dynamic pathology within the domain of vascular geometry may explain the evolution of aneurysms in cerebral arteries and cardiomyopathies even in the absence of anatomical and physiological abnormalities.
WITHDRAWN: Market weight, slaughter age, and yield grade to determine economic carcass traits and primal cuts yield of Hanwoo beef
Authors: Kwon Ki-Mun , Jeon Hwa-Eun , Han Seung-Ju , Woo Hee-Chan , Heo Sung-Min , Hong Hyoung Ki , Nogoy Kim Margarette C. , Choi Seong Ho 
Published: November 2021

Abstract
ObjectiveThis study was conducted to evaluate the relationship between market weight, slaughter age, yield grade, and primal cut yield in Hanwoo. MethodsA total of 403 Hanwoo (Korean native cattle) was assessed for carcass traits such as carcass cold weight, backfat thickness, ribeye area, dressing percentage, yield index, and marbling score. The production yield of the individual major primal cuts of Hanwoo beef was also measured. FindingsCarcass cold weight, ribeye area, and backfat thickness, which affect meat quality increased with increased market weight (p<0.05). The production yield of the ten major primal cuts also increased with increased market weight (p<0.05). In terms of slaughter age, carcass cold weight, ribeye area, and backfat thickness all increased from 25 months to 28-29 months, and the production yield of all prime cuts also increased with increasing slaughter age. According to the meat yield grade, carcass cold weight and backfat thickness increased from grade A to grade C, although the ribeye area was not affected. The combined findings of the study suggest that slaughtering Hanwoo at the weight of 651-700 kg and 701-750 and age of 28.23 and 29.83 months might be desirable to achieve the best quality and quantity grade of Hanwoo beef. However, the positive correlation of carcass cold weight and backfat thickness, and the negative correlation of the yield index according to primal cuts yield indicated that it is necessary to couple the slaughtering management of cattle with improved genetic and breeding method of Hanwoo to increase the production yield of the major prime cuts of Hanwoo beef.
Intermittent Fasting Reduces Neuroinflammation in Intracerebral Hemorrhage Through the Sirt3/Nrf2/HO-1 Pathway
Authors: Dai Shuhui , Wei Jialiang , Zhang Hongchen , Luo Peng , Yang Yuefan , Jiang Xiaofan , Fei Zhou , Liang Wenbin , Jiang Jianli , Li Xia 
Published: November 2021

Abstract
Background: Inflammation contributes to the poor prognosis of intracerebral hemorrhage (ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in multiple pathogenic processes. In the present study, we aimed to investigated the beneficial effects of IF in attenuating neuroinflammation and neurological deficits in a mouse model of ICH and to investigate the underlying mechanism.Methods: ICH was modelled by intrastriatal injection of autologous blood and IF was modelled by every-other-day feeding in male control mice (C57BL6), mice with and microglia specific knockout Sirt3f/f;Cx3cr1-Cre (Sirt3 cKO), and Sirt3f/f (wild-type) mice. Brain tissues and arterial blood were harvested at 1, 3, 7 and 28 days after ICH for immunohistochemistry analysis of Iba-1, DARPP-32 and HO-1, morphological analysis by HE staining and inflammatory factor release tests by ELISA. Motor functions were approached by corner turn and forelimb use asymmetry tests. Fluorescent double-labelled staining of Iba-1 with CD16, Arg1 or Sirt3 was used to provide direct image of co-expression of these molecules in microglia. TUNEL and Nissl staining was performed to evaluate cellular injuries. Results: IF alleviated neurological deficits in both acute and chronic phases after ICH. Morphologically, IF enhanced hematoma clearance, reduced brain edema in acute phase and attenuated striatum atrophy in chronic phase. In addtition, IF decreased the numbers of TUNEL+ cells and increased Nissl+ neuron number at day 1, 3 and 7 after ICH. IF suppressed CD16+Iba-1+ microglia activation at day 3 after ICH and reduced inflammatory releases, such as IL-1β and TNF-α. The above effects of IF were attenuated by microglia Sirt3 deletion partly because of an inhibition of Nrf2/HO-1 signalling pathway. Interestingly, IF increased Iba-1+ microglia number at day 7 which mainly expressed Arg1 while decreased the proinflammatory factor levels. In mice with microglia-specific Sirt3 deletion, the effects of IF on Iba-1+ microglia activation and anti-inflammatory factor expressions were attenuated as compared to wild-type Sirt3f/f mice. Conclusions: IF protects against ICH by suppressing the inflammatory responses via the Sirt3/Nrf2/HO-1 pathway.
Measuring Correlated Qubit Errors on Quantum Computers
Authors: Schales Peyton 
Published: November 2021

Abstract
Quantum computing is an emerging technology that, with its exponential computational speedup, will allow us to solve a new level of hard problems. From rapid vaccine development, efficient discovery of exotic materials, and complex AI models, to quickly cracking RSA encryption, quantum computers have the potential to revolutionize science. However, for quantum computing to solve these problems, quantum error correction methods are needed to eliminate qubit errors. An underlying assumption of current quantum error correction is that qubit errors are not correlated. If correlated qubit errors are prevalent, quantum error correction will be difficult, if not impossible. In this work, I developed a method to identify correlated errors between pairs of qubits and used this method to determine if correlations exist on current small-scale quantum computers. My method uses independence of error probabilities P(qa) ⨉ P(qb) = P(qaqb) to determine correlation. After running 40 million experiments to collect error probabilities by varying the quantum gates, number of gates, and pairs of qubits on multiple quantum computers, I found that these computers have a high occurrence of correlated qubit errors when qubits are topological neighbors. For example, I found that Hadamard gate operations can cause correlated errors, supported by a p-value of 0.0160. My work shows that the assumption that qubit errors are not correlated is incorrect for current quantum computers. In the future, scientists can use these methods to test for correlated errors as they develop new quantum computers, enabling quantum computing to achieve its full potential.
East Asian summer monsoon enhanced by COVID-19
Authors: He Chao , Zhou Wen , Li Tim , Zhou Tianjun , Wang Yuhao 
Published: November 2021

Abstract
Anthropogenic emissions decreased dramatically during the COVID-19 pandemic, but its possible effect on monsoon is unclear. Based on coupled models participating in the COVID Model Intercomparison Project (COVID-MIP), we show modeling evidence that the East Asian summer monsoon (EASM) is enhanced in terms of both precipitation and circulation, and the amplitude of the forced response reaches about 1/3 of the standard deviation for interannual variability. The response of EASM to COVID-19 is consistent with the response to the removal of all anthropogenic aerosols simulated by atmospheric component models, which confirms the dominant role of the fast response to reduced aerosols. The observational evidence, i.e., the anomalously strong EASM observed in 2020 and 2021, also supports the simulated enhancement of EASM. The essential mechanism for the enhanced EASM in response to COVID-19 is the enhanced zonal thermal contrast between Asian continent and the western North Pacific in the troposphere, particularly at the upper troposphere, due to the reduced aerosol concentration over Asian continent and the associated latent heating feedback. As the enhancement of EASM is a fast response to the reduction in aerosols, the effect of COVID-19 on EASM dampens soon after the rebound of emissions based on the models participating in COVID-MIP.
Correlation between Job Burnout and Fear of COVID-19 among ICU and CCU Nurses
Authors: Golabi F. , Aghdam M. B. Alizadeh , Akbarian H. , Mazraehshadi M. M. Hosseini 
Published: November 2021

Abstract
Background: Occupational burnout among nurses is one of the major factors which affect the quality of nursing care. Assessing the relationship between burnout and its associated factors is one of the most basic things that should be done so that later, actions can be taken to reduce burnout. Fear of COVID-19 is one of the factors that can increase burnout of nurses during the Coronavirus Disease 2019(COVID-19) pandemic.Aim: To investigate the relationship between job burnout and fear of COVID-19 among ICU and CCU nurses.Methods: The Maslach Burnout Inventory (MBI) and the Fear of COVID-19 Scale (FCV-19S) were distributed to ICU and CCU nurses (n = 170) at Shahid Madani Cardiac Hospital, Tabriz, Iran, and the correlation between job burnout and fear of COVID-19 was calculated.Results: The results show that the level of emotional exhaustion and reduced personal accomplishment among participants of this study is average, and depersonalization is at a low level. Also, the level of fear of coronavirus is below average among the respondents. The research showed that emotional exhaustion and fear of COVID-19 were positively correlated (p < 0.05), but there was not any significant correlation between depersonalization and fear of Coronavirus; as the relationship between reduced personal accomplishment and fear of COVID-19. In addition, there were significant correlations between age and reduced personal accomplishment, as well as marital status and reduced personal accomplishment (p < 0.05). On the other hand, the results showed that there were not any significant correlations between gender and burnout dimensions, nor between educational degree and burnout dimensions.Conclusion: As job burnout reduces the quality of nursing care, managers must take strategies that reduce job burnout. One of the strategies that they can take is to reduce the fear of COVID-19 by taking wise strategies.
Plasma Lipidome Acts as Diagnostic Marker and Predictor for Cyclosporin Response in Patients with Aplastic Anemia
Authors: Ruan Jing , Yang Chen , Du Yali , Chen Miao , Han Bing 
Published: November 2021

Abstract
The lipid metabolomic profile has been well defined in the pathogenesis and differential diagnosis in patients with different myeloid diseases. We assumed that the serum lipid metabolites could also help the diagnosis and prognostic prediction of aplastic anemia (AA). In this study, serum lipid profiles were explored in AA patients before and after cyclosporin (CsA) treatment. Meanwhile, hypocellular myelodysplastic syndrome (h-MDS) patients and the healthy volunteers were compared as controls. 15 AA patients, 11 h-MDS patients and 20 age and sex matched health controls were enrolled. All the AA patients were diagnosed to be non-severe aplastic anemia with transfusion dependency and were treated by CsA 3-5mg/kg/d for at least 6 months. AA patients had decreased arachidonic acid pathway metabolites and retinol metabolism-related metabolites as compared with h-MDS and the health (P<0.05), whereas h-MDS patients had increased metabolism of proline and threonine and abnormal sphingolipid metabolism compared with AA patients and the normal controls. After 6-month of CsA treatment, serum arachidonic acid, PGE2, PGJ2, 15(S)-HETE, leukotriene B4 and Protectin D1 decreased significantly. Patients who had response to CsA had higher levels of baseline protectin D1 (p=0.011), leukotriene B4 (p=0.011), 15(S)-HETE (p=0.004) and all-trans-retinal (p=0.000) than those who had no response.
Geographic pattern of phytoplankton community and their drivers in lakes of middle and lower reaches of Yangtze River floodplain, ChinaGeographic pattern of phytoplankton community and their drivers in lakes of middle and lower reaches of Yangtze River floodplain, China
Authors: Xiao Zhe , Li Hua , Li Xiaochuang , Li Renhui , Huo Shouliang , Yu Gongliang 
Published: November 2021

Abstract
Disentangling the relative contributions of deterministic and stochastic processes were critical to compressive understanding of underlying mechanism governing geographic pattern and assembly of phytoplankton community, while it was seldom performed in connected lakes under human pressure. Here, we investigated phytoplankton community pattern in relation to environmental and spatial factors over 81 lakes located in middle and lower reaches of Yangtze River (MLYR) floodplain, where many lakes suffered eutrophication and cyanobacterial blooms. A majority of MLYR lakes had higher phytoplankton abundance surpassing 107 cells/L, and were dominated by common bloom-forming cyanobacterial genera, including Pseudanabaena, Microcystis, Merismopedia, Dolichospermum, Limnothrix, and Raphidiopsis. Phytoplankton community exhibited a striking geographical pattern both for taxonomic and functional compositions, while functional groups were less sensitive and disimmilarity in communities displayed no significant increases with increasing geographical distance. Further, species richness explained much higher percentage of community variations than species turnover, indicating a reduced effect of environmental filtering of phytoplankton species with tolerance to similar environments in connected MLYR lakes. Both deterministic and stochastic processes governed assembly and biogeographic of phytoplankton community. Variation partition analysis showed spatial factors exhibited greater influence on phytoplankton community compared to environmental variables. The stronger influence of spatial factors was further demonstrated by Mantel test and neutral community model. These findings indicate deterministic and stochastic processes exhibited similar biogeographic patterns for phytoplankton community in MLYR lakes, but stochastic process was overwhelmingly dominated. Moreover, a large proportion of unexplained variation implies complex interactions exist to shape assembly mechanism of phytoplankton community in MLYR lakes.