bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peritoneal dialysis–first initiative in India: a cost-effectiveness analysis
Authors: Gupta Dharna , Jyani Gaurav , Ramachandran Raja , Bahuguna Pankaj , Ameel Mohammed , Dahiya Bharat Bhushan , Kohli Harbir Singh , Prinja Shankar , Jha Vivekanand 
Published: July 2021

ABSTRACTBackgroundThe increasing burden of kidney failure (KF) in India necessitates provision of cost-effective kidney replacement therapy (KRT). We assessed the comparative cost-effectiveness of initiating KRT with peritoneal dialysis (PD) or haemodialysis (HD) in the Indian context.MethodsThe cost and clinical effectiveness of starting KRT with either PD or HD were measured in terms of life years (LYs) and quality-adjusted life years (QALYs) using a mathematical Markov model. Complications such as peritonitis, vascular access–related complications and blood-borne infections were considered. Health system costs, out-of-pocket expenditures borne by patients and indirect costs were included. Two scenarios were considered: Scenario 1 (real-world scenario)—as per the current cost and utilization patterns; Scenario 2 (public programme scenario)—use in the public sector as per Pradhan Mantri National Dialysis Programme (PMNDP) guidelines. The lifetime costs and health outcomes among KF patients were assessed.ResultsThe mean QALYs lived per KF person with PD and HD were estimated to be 3.3 and 1.6, respectively. From a societal perspective, a PD-first policy is cost-saving as compared with an HD-first policy in both Scenarios 1 and 2. If only the costs directly attributable to patient care (direct costs) are considered, the PD-first treatment policy is estimated to be cost-effective only if the price of PD consumables can be brought down to INR70/U.ConclusionsPD as initial treatment is a cost-saving option for management of KF in India as compared with HD first. The government should negotiate the price of PD consumables under the PMNDP.
Improved Collision Detection Of MD5 Using Sufficient Condition Combination
Authors: Shen Yanzhao , Wu Ting , Wang Gaoli , Dong Xinfeng , Qian Haifeng 
Published: July 2021

Abstract
Counter-cryptanalysis uses cryptanalytic techniques to detect cryptanalytic attacks. It was introduced by Stevens with a collision detection algorithm that detects whether a message is one of a colliding message pair constructed using a collision attack. Later, Stevens and Shumow improved the collision detection against SHA-1 by using unavoidable conditions. However, there are no results improving collision detection against MD5 due to its weak diffusion properties. In this paper, an improved collision detection algorithm against MD5 is proposed by using the 14-bit sufficient condition combinations. This leads to the dividing the 223 classes into four sets. Each element, belonging to the first two sets, holds the same sufficient condition combination. Our new algorithm can classify 126 classes efficiently. The runtime is 28.6% of the previous collision detection method.
Transition from esophagectomy to endoscopic therapy for early esophageal cancer
Authors: Dunn Jason M , Reyhani Arasteh , Santaolalla Aida , Zylstra Janine , Gimson Eliza , Pennington Mark , Baker Cara , Kelly Mark , Van Hemelrijck Mieke , Lagergren Jesper , Zeki Sebastian S , Gossage James A , Davies Andrew R 
Published: July 2021

Summary

Background
To assess the outcomes of patients with early esophageal cancer and high-grade dysplasia comparing esophagectomy, the historical treatment of choice, to endoscopic eradication therapy (EET).

Methods
Retrospective cohort study of consecutive patients with early esophageal cancer/high-grade dysplasia, treated between 2000 and 2018 at a tertiary center. Primary outcomes were all-cause and disease-specific mortality assessed by multivariable Cox regression and a propensity score matching sub analysis, providing hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, tumor grade (G1/2 vs. G3), tumor stage, and lymphovascular invasion. Secondary outcomes included complications, hospital stay, and overall costs.

Results
Among 269 patients, 133 underwent esophagectomy and 136 received EET. Adjusted survival analysis showed no difference between groups regarding all-cause mortality (HR 1.85, 95% CI 0.73, 4.72) and disease-specific mortality (HR 1.10, 95% CI 0.26, 4.65). In-hospital and 30-day mortality was 0% in both groups. The surgical group had a significantly higher rate of complications (Clavien–Dindo ≥3 26.3% vs. endoscopic therapy 0.74%), longer in-patient stay (median 14 vs. 0 days endoscopic therapy) and higher hospital costs(£16 360 vs. £8786 per patient).

Conclusion
This series of patients treated during a transition period from surgery to EET, demonstrates a primary endoscopic approach does not compromise oncological outcomes with the benefit of fewer complications, shorter hospital stays, and lower costs compared to surgery. It should be available as the gold standard treatment for patients with early esophageal cancer. Those with adverse prognostic features may still benefit from esophagectomy.
Global Moments and the Rise of Area Studies and Development Theory in Germany, 1914–1945
Authors: Gross Stephen G 
Published: July 2021

Abstract
Scholars have often portrayed development theory as a new discipline that grew out of America’s rise to global power during and after the Second World War. This article adds to the complex origin story of development theory by showing how questions of population growth in agrarian countries, poverty and unemployment, and anxieties about supply chains led German economists in the interwar years to anticipate post-1945 theories of and strategies for the economic development of ‘Third World’ countries. It argues that development theory arose not only from discrete intellectual or political trends affecting a single country, but also from broader structural processes that were changing the nature of global relations, such as world war and the increased movement of refugees. More specifically, this discipline was an imperial tool used by German elites, then later by Americans, to try to manage the effects of population growth and global interdependence in their nation’s favour by learning more about their less economically developed commercial partners. In contrast to American or British experts who saw migration as the best solution to the challenge of rural unemployment and ‘overpopulation’—a term new to the post-1919 world—German economists crafted new agrarian development schemes. They saw the development of south-eastern Europe as a way to embed these smaller states in a larger, regional German bloc.
FD-injection-based elastic wavefield separation for open and closed configurations
Authors: Thomsen Henrik R , Koene Erik F M , Robertsson Johan O A , van Manen Dirk-Jan 
Published: July 2021

SUMMARYAn important step in the processing of seismic data that are recorded at the free surface is the isolation of the primary incident wavefield from the total recorded wavefield (which is contaminated with the immediate reflections off the free surface). We present a 3-D wavefield reconstruction technique, based on numerical wavefield injection along a closed boundary, that allows us to isolate this primary wavefield from measurements at the free surface. The technique consists of injecting only the three-component particle velocity recordings acquired at the free surface into a numerical wavefield simulation, and additionally requires information about the medium properties. The result of our proposed procedure is the separation of elastic waves into their first-order incident and reflected constituents, even when the recording or injection surface has sharp corners. With the use of synthetic data it is shown that the method achieves close to numerically exact wavefield separation, provided that the true elastic model in the interior is used. In practice, the parameters for a homogeneous elastic model can be determined efficiently from the surface data itself using an optimization scheme. Finally, the wavefield separation technique is successfully applied to experimental data, with particle velocity recordings acquired along five faces of a cubic granite rock volume. In addition to characterizing materials in laboratories, the presented technique has applications in numerical modelling and in so-called immersive experimentation, where the incident field is required to immerse an elastic object in an arbitrary larger, virtual elastic environment.
Seismic anisotropy, dominant slip systems and phase transitions in the lowermost mantle
Authors: Chandler Brian Chase , Chen Li-Wei , Li Mingming , Romanowicz Barbara , Wenk Hans-Rudolf 
Published: July 2021

SUMMARY
The presence of seismic anisotropy at the base of the Earth's mantle is well established, but there is no consensus on the deformation mechanisms in lower mantle minerals that could explain it. Strong anisotropy in magnesium post-perovskite (pPv) has been invoked, but different studies disagree on the dominant slip systems at play. Here, we aim to further constrain this by implementing the most recent results from atomistic models and high-pressure deformation experiments, coupled with a realistic composition and a 3-D geodynamic model, to compare the resulting deformation-induced anisotropy with seismic observations of the lowermost mantle. We account for forward and reverse phase transitions from bridgmanite (Pv) to pPv. We find that pPv with either dominant (001) or (010) slip can both explain the seismically observed anisotropy in colder regions where downwellings turn to horizontal flow, but only a model with dominant (001) slip matches seismic observations at the root of hotter large-scale upwellings. Allowing for partial melt does not change these conclusions, while it significantly increases the strength of anisotropy and reduces shear and compressional velocities at the base of upwellings.
Transcriptome of HPβCD-treated Niemann-Pick disease type C1 cells highlights GPNMB as a biomarker for therapeutics
Authors: Rodriguez-Gil Jorge L , Baxter Laura L , Watkins-Chow Dawn E , Johnson Nicholas L , Davidson Cristin D , Carlson Steven R , Incao Arturo A ,   NISC Comparative Sequencing Program, Wallom Kerri L , Farhat Nicole Y , Platt Frances M , Dale Ryan K , Porter Forbes D , Pavan William J 
Published: July 2021

AbstractThe rare, fatal neurodegenerative disorder Niemann-Pick disease type C1 (NPC1) arises from lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurological degeneration and premature death. The timing and severity of NPC1 clinical presentation is extremely heterogeneous. This study analyzed RNA-Seq data from 42 NPC1 patient-derived, primary fibroblast cell lines to determine transcriptional changes induced by treatment with 2-hydroxypropyl-β-cyclodextrin (HPβCD), a compound currently under investigation in clinical trials. A total of 485 HPβCD-responsive genes were identified. Pathway enrichment analysis of these genes showed significant involvement in cholesterol and lipid biosynthesis. Furthermore, immunohistochemistry of the cerebellum as well as measurements of plasma from Npc1m1N null mice treated with HPβCD and adeno-associated virus gene therapy suggests that one of the identified genes, GPNMB, may serve as a useful biomarker of treatment response in NPC1 disease. Overall, this large NPC1 patient-derived dataset provides a comprehensive foundation for understanding the genomic response to HPβCD treatment.
A Gut-Specific LITAF-Like Gene in Antheraea pernyi (Lepidoptera: Saturniidae) Involved in the Immune Response to Three Pathogens
Authors: Lei Yuyu , Li Ying , Yang Xinfeng , Zhu Xuwei , Zhang Xian , Du Jie , Liang Shimei , Li Shanshan , Duan Jianping 
Published: July 2021

Abstract
Antheraea pernyi (Guérin-Méneville 1855) is an important resource for silk, food, and biohealth products; however, exogenous pathogens largely affect the commercial application potential of this species. Since the gut is a key organ for the digestion and absorption of nutrients as well as for immune defense, we used comparative transcriptome analysis to screen for a gut-specific molecular tool for further functional research in A. pernyi. In total, 3,331 differentially expressed genes (DEGs) were identified in the gut compared with all other pooled tissues of A. pernyi, including 1,463 upregulated genes in the gut. Among these, we further focused on a lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) gene because of its high gut-specific expression and the presence of a highly conserved SIMPLE-like domain, which is related to the immune response to pathogenic infections in many species. The cDNA sequence of ApLITAF was 447-bp long and contained a 243-bp open reading frame encoding an 80-amino acid protein. Immune challenge assays indicated that ApLITAF expression was significantly upregulated in the gut of A. pernyi naturally infected with nucleopolyhedrovirus (NPV) or fed leaves infected with the gram-negative bacterium Escherichia coli (Migula 1895) and the gram-positive bacterium Bacillus subtilis (Ehrenberg 1835). Cell transfection showed that ApLITAF localized to the lysosome. Collectively, these results suggested that ApLITAF played a role in the immune response of A. pernyi and could facilitate the future research and breeding application in this species.
Comparing single- and mixed-species groups in fruit flies: differences in group dynamics, but not group formation
Authors: Girardeau Anna R , Foley Brad R , Saltz Julia B 
Published: July 2021

AbstractMixed-species groups describe active associations among individuals of 2 or more species at the same trophic level. Mixed-species groups are important to key ecological and evolutionary processes such as competition and predation, and research that ignores the presence of other species risks ignoring a key aspect of the environment in which social behavior is expressed and selected. Despite the defining emphasis of active formation for mixed-species groups, surprisingly little is known about the mechanisms by which mixed-species groups form. Furthermore, insects have been almost completely ignored in the study of mixed-species groups, despite their taxonomic importance and relative prominence in the study of single-species groups. Here, we measured group formation processes in Drosophila melanogaster and its sister species, Drosophila simulans. Each species was studied alone, and together, and one population of D. melanogaster was also studied both alone and with another, phenotypically distinct D. melanogaster population, in a nested-factorial design. This approach differs from typical methods of studying mixed-species groups in that we could quantitatively compare group formation between single-population, mixed-population, and mixed-species treatments. Surprisingly, we found no differences between treatments in the number, size, or composition of groups that formed, suggesting that single- and mixed-species groups form through similar mechanisms of active attraction. However, we found that mixed-species groups showed elevated interspecies male–male interactions, relative to interpopulation or intergenotype interactions in single-species groups. Our findings expand the conceptual and taxonomic study of mixed-species groups while raising new questions about the mechanisms of group formation broadly.
Systemic therapy for hepatocellular carcinoma: current status and future perspectives
Authors: Furuse Junji , Ueno Makoto , Ikeda Masafumi 
Published: July 2021

AbstractSince sorafenib was established as the standard of care for patients with advanced hepatocellular carcinoma, various tyrosine kinase inhibitors, targeting vascular endothelial growth factor receptor and other molecular growth factors, have been developed. Lenvatinib demonstrated non-inferiority to sorafenib in terms of the overall survival, and it has also become confirmed as another standard of care for patients with advanced hepatocellular carcinoma. Recently, various immune checkpoint inhibitors have been investigated, either as monotherapy or in combination with another agent, and superiority of the combination of atezolizumab plus bevacizumab, in terms of the overall survival and progression-free survival, has been demonstrated over sorafenib, which is recognized as the treatment regimen of first choice for first-line systemic therapy of advanced hepatocellular carcinoma. Regorafenib, cabozantinib and ramucirumab have been demonstrated to show survival benefits as second-line treatment agents for progressive disease after first-line sorafenib treatment. There are still various medical requirements in systemic therapy for hepatocellular carcinoma. To date, no evidence has been established for the selection of sequential treatment after immune checkpoint inhibitor-containing treatments, especially atezolizumab plus bevacizumab. A promising treatment for Child-Pugh class B hepatocellular carcinoma patients is also an urgent medical need that has not yet been met. Although there are some difficulties in establishing the needed evidence, well-designed clinical trials are warranted.
Evaluation of the Success of Weight Loss Programs Using the Fit for Performance Curriculum
Authors: Wonn Jessica , Khan Joetta 
Published: July 2021

ABSTRACT

Introduction
Overweight and obesity rates continue to rise among U.S. Army soldiers, which impacts their overall readiness status and puts them at greater risk for musculoskeletal injury and development of chronic disease. To address the concern with obesity and ensure that Soldiers are meeting body composition standards, the Army offers Fit for Performance-Weight Loss Strategies curriculum, a program of standardized material on nutrition and physical activity presented over six 1-hour sessions. This study aimed to evaluate the success and attrition of weight loss programs using the Fit for Performance curriculum in an Army setting among TRICARE regions.

Materials and Methods
This retrospective cohort study consolidated data on participants in weight loss programs using the Fit for Performance curriculum. It examines attrition rates, weight loss, change in body mass index (BMI), factors influencing weight loss, and attrition based on geographical location. Statistical analysis was completed using R Core Team software, version 3.6.1, for t-tests, linear regression, and analysis of variance. Significance was set at P ≤ .05. This study was determined to be exempt by the Walter Reed National Military Hospital Institutional Review Board.

Results
In total, 8,336 U.S. Army soldiers (80% male, mean age = 26.2 ± 6.9 years) participated in the program. Attrition rates were high (96.4%). Those who attended 4-6 sessions lost significantly more weight than those who attended 1-3 sessions (0.72 kg [1.60 lbs], P &lt; .001); however, weight lost was not clinically significant. Sex, age, and number of sessions attended influenced to the amount of weight lost, but only accounted for 4% of the variation. Among TRICARE regions there was a significant difference in attrition rates, with those in the Western (1.2 sessions, P &lt; .001) and Overseas (1.6 sessions, P &lt; .001) regions attending statistically fewer sessions than those in the Eastern region.

Conclusions
Consistent attendance in a weight loss program promotes changes in BMI, which may improve the health of the force. However, the factors influencing these changes are unclear. The results indicate opportunities to re-examine current processes and the program elements to encourage increased or complete participation and determine if program element changes are warranted for the Fit for Performance-Weight Loss Strategies Program. Attrition rates were high, indicating opportunities to research reasons for attendance and attrition in the future. Finally, these findings highlight an opportunity for educating the military leadership on the increased success with increased attendance.
Too Hot to Handle: Early Temperature Management and Unique Treatment of Hyperpyrexia in SARS-CoV2 Encephalopathy
Authors: Micci Luca , DesRosiers Taylor 
Published: July 2021

ABSTRACT
A 45-year-old otherwise healthy active duty male was admitted to the medical intensive care unit for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) encephalopathy associated with hyperpyrexia. Magnetic resonance imaging findings demonstrated cytotoxic lesions primarily at the midline of the splenium of corpus callosum (CLOCC). Similar cases involving hyperpyrexia in the setting of SARS-CoV2 infection have demonstrated exceedingly high-mortality outcomes. Three mechanisms exist as to the likely underlying pathophysiology of SARS-CoV2-induced hyperpyrexia: direct brain injury, persistent immune dysregulation of cytokines, and vascular thrombosis. To date, no cases have reported imaging findings consistent with SARS-CoV2-induced brain injury leading to hyperpyrexia. Magnetic resonance imaging findings in this case, however, may finally elucidate the underlying mechanism for hyperpyrexia in this population. Magnetic resonance imaging findings in this case show diffusion restriction of the corpus callosum without evidence of any Central Nervous System (CNS) vessel abnormality. Given that hyperpyrexia has a clear association with increased mortality and morbidity in the SARS-CoV2 infected population, the decision to initiate steroids and remdesivir regardless of respiratory status was made for the concern for severe SARS-CoV2 infection as demonstrated by the CLOCC. Additional cases will be needed to assess their potential use as a radiological marker of disease burden.
Scintillation of PSR B1508+55 – the view from a 10 000-km baseline
Authors: Marthi V R , Simard D , Main R A , Pen U-L , van Kerkwijk M H , Vanderlinde K , Gupta Y , Roberts C , Quine B M 
Published: July 2021

ABSTRACT
We report on the simultaneous Giant Metrewave Radio Telescope (GMRT) and Algonquin Radio Observatory (ARO) observations at 550–750 MHz of the scintillation of PSR B1508+55, resulting in an ∼10 000-km baseline. This regime of measurement lies between the shorter few 100- to 1000-km baselines of earlier multistation observations and the much longer earth–space baselines. We measure a scintillation cross-correlation coefficient of 0.22, offset from zero time lag due to a ∼45-s traversal time of the scintillation pattern. The scintillation time of 135 s is 3× longer, ruling out isotropic as well as strictly one-dimensional scattering. Hence, the low cross-correlation coefficient is indicative of highly anisotropic but two-dimensional scattering. The common scintillation detected on the baseline is confined to low delays of ≲1μs, suggesting that this correlation may not be associated with the parabolic scintillation arc detected at the GMRT. Detection of pulsed echoes and their direct imaging with the Low-Frequency Array (LOFAR) by a different group enable them to measure a distance of 125 pc to the screen causing these echoes. These previous measurements, alongside our observations, lead us to propose that there are at least two scattering screens: the closer 125-pc screen causing the scintillation arc detected at GMRT, and a screen further beyond causing the scintillation detected on the GMRT-ARO baseline. We advance the hypothesis that the 125-pc screen partially resolves the speckle images on the screen beyond leading to loss of coherence in the scintillation dynamic spectrum to explain the low cross-correlation coefficient.