bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lesser spot-nosed monkeys coordinate alarm call production with associated Campbell’s monkeys
Authors: Le Floch Auriane , Bouchard Alice , Gallot Quentin , Zuberbühler Klaus 
Published: July 2021

Abstract
Forest monkeys often form semi-permanent mixed-species associations to increase group-size related anti-predator benefits without corresponding increases in resource competition. In this study, we analysed the alarm call system of lesser spot-nosed monkeys, a primate that spends most of its time in mixed-species groups while occupying the lowest and presumably most dangerous part of the forest canopy. In contrast to other primate species, we found no evidence for predator-specific alarm calls. Instead, males gave one general alarm call type (‘kroo’) to three main dangers (i.e., crowned eagles, leopards and falling trees) and a second call type (‘tcha-kow’) as a coordinated response to calls produced in non-predatory contexts (‘boom’) by associated male Campbell’s monkeys. Production of ‘kroo’ calls was also strongly affected by the alarm calling behaviour of male Campbell’s monkeys, suggesting that male lesser spot-nosed monkeys adjust their alarm call production to another species’ vocal behaviour. We discuss different hypotheses for this unusual phenomenon and propose that high predation pressure can lead to reliance on other species vocal behaviour to minimise predation.

Significance statement
Predation can lead to the evolution of acoustically distinct, predator-specific alarm calls. However, there are occasional reports of species lacking such abilities, despite diverse predation pressure, suggesting that evolutionary mechanisms are more complex. We conducted field experiments to systematically describe the alarm calling behaviour of lesser spot-nosed monkeys, an arboreal primate living in the lower forest strata where pressure from different predators is high. We found evidence for two acoustically distinct calls but, contrary to other primates in the same habitat, no evidence for predator-specific alarms. Instead, callers produced one alarm call type (‘kroo’) to all predator classes and another call type (‘tcha-kow’) to non-predatory dangers, but only as a response to a specific vocalisation of Campbell’s monkeys (‘boom’). The production of both calls was affected by the calling behaviour of Campbell’s monkeys, suggesting that lesser spot-nosed monkey vocal behaviour is dependent on the antipredator behaviour of other species. Our study advances the theory of interspecies interactions and evolution of alarm calls.
Keratin 7 expression in hepatic cholestatic diseases
Authors: Sakellariou S. , Michaelides C. , Voulgaris T. , Vlachogiannakos J. , Manesis E. , Tiniakos D. G. , Delladetsima I. 
Published: July 2021

AbstractWe evaluated keratin 7 (K7) hepatocellular expression in 92 patients with common types of acute and chronic cholestatic diseases caused by bile duct obstruction/destruction or parenchymal lesions [acute hepatitis (n=20), mixed/pure cholestasis (n=16), primary biliary cholangitis-PBC (n=35), primary sclerosing cholangitis-PSC (n=10), vanishing bile duct syndrome (n=3), complete large bile duct obstruction due to space-occupying lesions (n=8)]. K7 immunohistochemical hepatocellular expression and ductular reaction (DR) were semi-quantitatively assessed. Results were correlated with liver enzyme serum levels, cholestasis type, histological features, hepatocellular Ki67 labelling index (LI) and HepPar1 expression. Hepatocellular K7 expression was detected in 87% (81/92) cases and in all cholestatic disease types with lowest incidence in pure/mixed cholestasis and highest in incomplete bile duct obstruction (iBDO), reaching 100% in PSC. K7-positive hepatocytes had low Ki67 LI (0-5%) retaining HepPar1 expression, irrespective of disease type. PSC cases had high K7 hepatocellular expression even with intact bile ducts, a feature that may aid differential diagnosis of cholestatic syndromes. K7 hepatocellular expression significantly correlated with cholestasis type, bile duct loss and fibrosis stage. It was higher in milder acute cholestatic hepatitis showing inverse correlation with hepatocyte proliferation and serum transaminase levels. In iBDO, younger age independently correlated with high K7 expression, while serum GGT levels showed a nearly significant correlation. Correlation with DR findings implied that K7-positive hepatocytes may result through metaplasia. In conclusion, K7 hepatocellular expression is a sensitive though non-specific marker of cholestasis. It may represent a cytoprotective reaction of resting hepatocytes in cholestasis of longer duration especially in younger patients.
The expression of tenascin-C in neural stem/progenitor cells is stimulated by the growth factors EGF and FGF-2, but not by TGFβ1
Authors: Theocharidis Ursula , Roll Lars , Faissner Andreas 
Published: July 2021

AbstractNeural stem/progenitor cells (NSPCs) rely on internal and external cues determining their lineage decisions during brain development. The progenitor cells of the embryonic mammalian forebrain reside in the ventricular and subventricular zones of the lateral ventricles, where they proliferate, generate neurons and glial cells, and respond to external cues like growth factors. The extracellular matrix (ECM) surrounds NSPCs and influences the cell fate by providing mechanical scaffold, trophic support, and instructive signals. The ECM molecule tenascin-C (Tnc) is expressed in the proliferative zones of the developing forebrain and involved in the proliferation and maturation of NSPCs. Here, we analyzed the regulation of the Tnc gene expression by NSPCs cultivated under the influence of different growth factors. We observed that the epidermal growth factor (EGF) and the fibroblast growth factor (FGF)-2 strongly increased the expression of Tnc, whereas the transforming growth factor (TGF)β 1 had no effect on Tnc gene expression, in contrast to previous findings in cell cultures of neural and non-neural origin. The stimulation of the Tnc gene expression induced by EGF or FGF-2 was reversible and seen in constantly treated as well as short term stimulated NSPC cultures. The activation depended on the presence of the respective receptors, which was slightly different in cortical and striatal NSPC cultures. Our results confirm the influence of extracellular stimuli regulating the expression of factors that form a niche for NSPCs during embryonic forebrain development.
Genotypic traits and tradeoffs of fast growth in silver birch, a pioneer tree
Authors: Mikola Juha , Koikkalainen Katariina , Rasehorn Mira , Silfver Tarja , Paaso Ulla , Rousi Matti 
Published: July 2021

AbstractFast-growing and slow-growing plant species are suggested to show integrated economics spectrums and the tradeoffs of fast growth are predicted to emerge as susceptibility to herbivory and resource competition. We tested if these predictions also hold for fast-growing and slow-growing genotypes within a silver birch, Betula pendula population. We exposed cloned saplings of 17 genotypes with slow, medium or fast height growth to reduced insect herbivory, using an insecticide, and to increasing resource competition, using naturally varying field plot grass cover. We measured shoot and root growth, ectomycorrhizal (EM) fungal production using ergosterol analysis and soil N transfer to leaves using 15N-labelled pulse of NH4+. We found that fast-growing genotypes grew on average 78% faster, produced 56% and 16% more leaf mass and ergosterol, and showed 78% higher leaf N uptake than slow-growing genotypes. The insecticide decreased leaf damage by 83% and increased shoot growth, leaf growth and leaf N uptake by 38%, 52% and 76%, without differences between the responses of fast-growing and slow-growing genotypes, whereas root mass decreased with increasing grass cover. Shoot and leaf growth of fast-growing genotypes decreased and EM fungal production of slow-growing genotypes increased with increasing grass cover. Our results suggest that fast growth is genotypically associated with higher allocation to EM fungi, better soil N capture and greater leaf production, and that the tradeoff of fast growth is sensitivity to competition, but not to insect herbivory. EM fungi may have a dual role: to support growth of fast-growing genotypes under low grass competition and to maintain growth of slow-growing genotypes under intensifying competition.
Nonlinear multiscale simulation of elastic beam lattices with anisotropic homogenized constitutive models based on artificial neural networks
Authors: Gärtner Til , Fernández Mauricio , Weeger Oliver 
Published: July 2021

AbstractA sequential nonlinear multiscale method for the simulation of elastic metamaterials subject to large deformations and instabilities is proposed. For the finite strain homogenization of cubic beam lattice unit cells, a stochastic perturbation approach is applied to induce buckling. Then, three variants of anisotropic effective constitutive models built upon artificial neural networks are trained on the homogenization data and investigated: one is hyperelastic and fulfills the material symmetry conditions by construction, while the other two are hyperelastic and elastic, respectively, and approximate the material symmetry through data augmentation based on strain energy densities and stresses. Finally, macroscopic nonlinear finite element simulations are conducted and compared to fully resolved simulations of a lattice structure. The good agreement between both approaches in tension and compression scenarios shows that the sequential multiscale approach based on anisotropic constitutive models can accurately reproduce the highly nonlinear behavior of buckling-driven 3D metamaterials at lesser computational effort.
Tracking mineral and geochemical characteristics of Holocene lake sediments: the case of Hotagen, west-central Sweden
Authors: Kanbar Hussein Jaafar , Tran Le Thai , Olajos Fredrik , Englund Göran , Holmboe Michael 
Published: July 2021

AbstractPurposeIntact lake sediments reflect the development of terrestrial ecosystems. This development can be understood by decoding mineral and geochemical information of sedimentary archives. Therefore, we characterized a Holocene lake sediment core and revealed bulk to micro-scale variations via a combination of geochemical techniques and statistical methods.MethodsA 2.3 m sediment core was collected from Hotagen, a lake in west-central Sweden; a sediment sample was collected every 5 cm. A part of each sediment sample was kept untreated (named bulk) and another part was size-fractionated into < 4, 4–16, 16–64, and > 64 µm subsamples. Characterization was then made with respect to grain size distribution (GSD), physico-chemical parameters, geochemical properties, organic composition, and mineralogy. The sediments were investigated at bulk, micro-, and elemental scales using powder X-ray diffraction (XRD), diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), and scanning electron microscopy coupled to energy-dispersive X-ray spectroscopy (SEM–EDX).ResultsThe deepest sediment was identified as glacial till dating back to the Late Pleistocene. The bulk sediments showed a clear distinction between 0–195 cm (unit 1, U1) and 200–225 cm (unit 2, U2) depths. Quartz and feldspar minerals decreased and organic matter and clay minerals increased from the till towards the lower limit of U1. The development in the sedimentary properties marked the transformation of the terrestrial ecosystem from glacier-covered land to vegetated areas. This development was also well reflected by the appearance of X-ray amorphous materials and the formation of distinct organo-mineral aggregates; chlorite was the predominant clay mineral in these aggregates. The geochemical variation between U2 and U1 sediments was further established by resolving the DRIFT spectral components through multivariate curve resolution alternating least square (MCR-ALS). The U1 sediments settled over a period of ~ 7500 years and showed comparable mineral, geochemical, and organic composition. However, the size-fractionated sediments, mainly < 4 µm, showed diverse mineral and geochemical composition. Indeed, these sediments were distinct by containing relatively higher amounts of X-ray amorphous materials and clay minerals, the latter had variable Na, Mg, and K contents.ConclusionThe combined use of geochemical and statistical approaches used in this study followed the mineral and geochemical development of sediments that had settled during the Late Pleistocene and Early Holocene Epochs. Finally, the U2 sediments marked the terrestrial ecosystem development that occurred during the late glaciation, deglaciation, and post-glaciation periods.Graphical abstract
Selbsthilfe und Gesundheitskompetenz während der Corona-Pandemie: Ergebnisse der qualitativen GeMSeHeCo-Studie
Authors: Kogel Lisa Marie , Steeb Natalie , Rathmann Katharina 
Published: July 2021

ZusammenfassungHintergrundDie Pandemie stellt Menschen mit Beeinträchtigung vor vielfältige Herausforderungen, insbesondere auch beim Umgang mit Gesundheitsinformationen. Bislang ist nur wenig über die Rolle der Selbsthilfe bei der Förderung der Gesundheitskompetenz ihrer Mitglieder während der Pandemie bekannt.MethodikDer Studie „Gesundheitskompetenz von Mitgliedern der Selbsthilfe: Herausforderungen durch die Corona-Pandemie (GeMSeHeCo)“ liegt ein qualitatives Studiendesign zugrunde. Der Feldzugang erfolgte deutschlandweit über die Selbsthilfegruppen. Von Juli bis Oktober 2020 wurdenN = 19 Telefoninterviews mit Vertreter*innen von Selbsthilfegruppen durchgeführt, transkribiert und inhaltsanalytisch ausgewertet.ErgebnisseVertreter*innen der Selbsthilfe berichteten über Stärken und Schwächen der Mitglieder im Umgang mit Gesundheitsinformationen während der Corona-Pandemie. Schwächen wurden v. a. bei älteren Mitgliedern, Menschen mit niedrigem Bildungsniveau und mit Migrationshintergrund berichtet. Stärken beobachteten die Vertreter*innen bei langjährigen Mitgliedern und bei Mitgliedern, die sich zu ihrer Krankheit kontinuierlich weiterbilden.DiskussionDie Selbsthilfe wird während der Pandemie als wichtige Unterstützung der Mitglieder im Umgang mit Gesundheitsinformationen wahrgenommen. Ein Vorteil für die Mitglieder besteht insbesondere in der Prüfung und Zusammenstellung von Gesundheitsinformationen nach individuellen Bedarfen durch die Selbsthilfe. Herausforderungen können aufgrund von Sprach- und Verständnisschwierigkeiten entstehen, bspw. durch einen Migrationshintergrund. Der Ausbau von digitalen Angeboten hat sich in dieser Zeit als hilfreich erwiesen. Dabei sollte die Unterstützung vermehrt Ältere und Mitglieder mit geringen finanziellen Möglichkeiten berücksichtigen, da diese während der Pandemie weniger Zugang zu digitalen Angeboten aufweisen.
Multistep batch-flow hybrid synthesis of a terbinafine precursor
Authors: Hergert Tamás , Mátravölgyi Béla , Örkényi Róbert , Éles János , Faigl Ferenc 
Published: July 2021

AbstractA three-step batch-flow hybrid process has been developed for an expeditious synthesis of the enynol key intermediate of antifungal terbinafine. This procedure involves consecutive organometallic steps without the necessity of any in-line purification: after a metalation by n-butyllithium, a selective addition of the lithium salt was elaborated followed by a Grignard reaction resulting in a high yield of 6,6-dimethylhept-1-en-4-yn-3-ol. Moreover, as an alternative to tetrahydrofuran, cyclopentyl methyl ether was used as solvent implementing a safe, sustainable, yet selective synthetic process. Even on a laboratory-scale, the optimized batch-flow hybrid process had a theoretical throughput of 41 g/h. Furthermore, the newly developed process provides an efficient synthesis route to the key-intermediate, while making acrolein obsolete, minimizing side-products, and enabling safe and convenient scale-up.
Is a PD game still a dilemma for Japanese rural villagers? A field and laboratory comparison of the impact of social group membership on cooperation
Authors: Mitani Yohei 
Published: July 2021

AbstractLocal norms and shared beliefs in cohesive social groups regulate individual behavior in everyday economic life. I use a door-to-door field experiment where a hundred and twenty villagers recruited from twenty-three communities in a Japanese rural mountainous village play a simultaneous prisoner’s dilemma game. To examine whether a set of experiences shared through interactions among community members affect experimental behavior, I compare villagers’ behavior under in-community and out-community random matching protocols. I also report a counterpart laboratory experiment with seventy-two university student subjects to address the external validity of laboratory experiments. The findings are three-fold. First, almost full cooperation is achieved when villagers play a prisoner’s dilemma game with their anonymous community members. Second, cooperation is significantly higher within the in-group compared to the out-group treatment in both the laboratory and field experiments. Third, although a significant treatment effect of social group membership is preserved, a big difference in the average cooperation rates is observed between the laboratory and field.
HANDLING DISTRUST ON RISK COMMUNICATION IN NIGERIA: A STRATEGY TO STRENGTHENING THE COVID-19 OUTBREAK RESPONSE
Authors: Ilesanmi Olayinka Stephen , Akosile Priscilla Onaopemipo , Afolabi Aanuoluwapo Adeyimika , Ukwenya Victor Okoliko 
Published: July 2021

Abstract

Background
This study aimed to assess the level of trust in the COVID-19 risk communication efforts in Nigeria.

Methods
We conducted a descriptive cross-sectional study among community members aged 15 years and above in Ondo state in October, 2020. Data were collected using an interviewer-administered questionnaire. Data were analyzed using SPSS version 22. Descriptive statistics were summarized using frequencies. Trust was ranked from “1” implying “Low level of trust” to “7” denoting “High level of trust”. We conducted bivariate Chi-square test on respondents’ level of trust in the Nigeria Centre for Disease Control (NCDC) and socio-demographic characteristics. The level of significance was set at p<0.05.

Results
Among the 691 respondents, 244 (35.3%) were aged 21 to 29 years, and 304 (51.4%) used the NCDC to obtain COVID-19 knowledge. Overall, 205 (41.8%) had high level of trust in the NCDC. Furthermore, 51 (51.5%) individuals aged 30-39 years had high level of trust in the NCDC (ᵡ2=17.455, p= 0.001). Also, 114 (48.5%) persons who lived with children below 18 years had high level of trust in the NCDC (ᵡ2= 8.266, p= 0.004).

Conclusion
Policy makers should prioritize the involvement of young and educated persons in COVID-19 risk communication strategies.
Risk factors and outcomes associated with community-onset and hospital-acquired coinfection in patients hospitalized for coronavirus disease 2019 (COVID-19): A multihospital cohort study
Authors: Petty Lindsay A. , Flanders Scott A. , Vaughn Valerie M. , Ratz David , O’Malley Megan , Malani Anurag N. , Washer Laraine , Kim Tae , Kocher Keith E. , Kaatz Scott , Czilok Tawny , McLaughlin Elizabeth , Prescott Hallie C. , Chopra Vineet , Gandhi Tejal 
Published: July 2021

AbstractBackground:We sought to determine the incidence of community-onset and hospital-acquired coinfection in patients hospitalized with coronavirus disease 2019 (COVID-19) and to evaluate associated predictors and outcomes.Methods:In this multicenter retrospective cohort study of patients hospitalized for COVID-19 from March 2020 to August 2020 across 38 Michigan hospitals, we assessed prevalence, predictors, and outcomes of community-onset and hospital-acquired coinfections. In-hospital and 60-day mortality, readmission, discharge to long-term care facility (LTCF), and mechanical ventilation duration were assessed for patients with versus without coinfection.Results:Of 2,205 patients with COVID-19, 141 (6.4%) had a coinfection: 3.0% community onset and 3.4% hospital acquired. Of patients without coinfection, 64.9% received antibiotics. Community-onset coinfection predictors included admission from an LTCF (OR, 3.98; 95% CI, 2.34–6.76; P < .001) and admission to intensive care (OR, 4.34; 95% CI, 2.87–6.55; P < .001). Hospital-acquired coinfection predictors included fever (OR, 2.46; 95% CI, 1.15–5.27; P = .02) and advanced respiratory support (OR, 40.72; 95% CI, 13.49–122.93; P < .001). Patients with (vs without) community-onset coinfection had longer mechanical ventilation (OR, 3.31; 95% CI, 1.67–6.56; P = .001) and higher in-hospital mortality (OR, 1.90; 95% CI, 1.06–3.40; P = .03) and 60-day mortality (OR, 1.86; 95% CI, 1.05–3.29; P = .03). Patients with (vs without) hospital-acquired coinfection had higher discharge to LTCF (OR, 8.48; 95% CI, 3.30–21.76; P < .001), in-hospital mortality (OR, 4.17; 95% CI, 2.37–7.33; P ≤ .001), and 60-day mortality (OR, 3.66; 95% CI, 2.11–6.33; P ≤ .001).Conclusion:Despite community-onset and hospital-acquired coinfection being uncommon, most patients hospitalized with COVID-19 received antibiotics. Admission from LTCF and to ICU were associated with increased risk of community-onset coinfection. Future studies should prospectively validate predictors of COVID-19 coinfection to facilitate the reduction of antibiotic use.
“The Band of Brothers”: The Mobilization of English Welsh Dual Identities in Second World War Britain
Authors: Ugolini Wendy 
Published: July 2021

AbstractIn the run-up to the Second World War, the War Office agreed to organize territorial units that recruited specifically on the grounds of English Welsh dual identities. These formations, which comprised the 99th London Welsh Heavy Anti-Aircraft regiment and the 46th Liverpool Welsh Royal Tank Regiment, began recruiting in 1939 from English cities with significant Welsh populations. This article explores the mobilization and performance of English Welsh identities during the Second World War and reflects upon why, at a time of global conflict, some English men opted to enlist on the basis of Welsh antecedents. Relatively little attention has been paid to the plurality of British identity in wartime or to how the existence of what historian Thomas Hajkowski has called “hybrid ‘dual identities’” within the constituent countries of the United Kingdom informed the functioning of Britishness during the Second World War. Making use of previously unpublished and original life-writing sources, this article illuminates the significance of dual identifications across two nations at once—in this case, Wales and England—within the multinational state of Britain at war. Overall, by examining the intersectionality between subjective wartime constructions of kin, home, and nation(s), it points to how a sense of dual identifications could feed into recruitment patterns and potentially bolster combat motivation and morale. By highlighting the interconnectedness between constituent nations of Britain, and the complexities of identity formation within Britishness, this article adds to the literature that complicates the notion of fixed singular national identities and underscores the importance of dual identifications within and across the borders of the constituent nations in advancing our understanding of twentieth-century Britain.