bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRISPR : le Nobel, enfin…
Authors: Jordan Bertrand 
Published: January 2021

Après Marie Curie, en 1903 et 1911, Irène Joliot-Curie en 1935, Françoise Barré-Sinoussi en 2008, Esther Duflo (franco-américaine) en 2019, Emmanuelle Charpentier est la cinquième française à décrocher un Prix Nobel (le Nobel de chimie 2020) qu’elle partage avec l’américaine Jennifer Anne Doudna. C’est la première fois qu’un prix Nobel scientifique est décerné conjointement à deux femmes.
Emmanuelle Charpentier (née le 11 décembre 1968 à Juvisy-sur-Orge, France), obtient un doctorat à l’Institut Pasteur, après un master à l’université Pierre et Marie Curie (UPMC, maintenant Sorbonne Université, Paris). Microbiologiste, généticienne et biochimiste, elle poursuit un cursus international au sein d’institutions américaines avant un retour en Europe (Suède et Allemagne). Elle est aujourd’hui professeure à l’Institut Max Planck de Science des Pathogènes à Berlin qu’elle a créé et qu’elle dirige.
Jennifer Anne Doudna (née le 19 février 1964 à Washington) est une professeure américaine de biochimie et de biologie moléculaire à l’université de Californie à Berkeley. Elle est titulaire d’une licence en chimie obtenue au Pomona College en 1985. Sa thèse de doctorat en biochimie, centrée sur l’étude des ribozymes, a été menée à l’université Harvard. Par la suite, elle a effectué un postdoctorat à l’université du Colorado à Boulder.
Endoscopic ultrasound-guided biliary drainage of malignant stenosis, not treatable with endoscopic retrograde cholangiopancreatography: a single-center, prospective observational study
Authors: Tarantino Ilaria , Peralta Marco , Ligresti Dario , Amata Michele , Barresi Luca , Cipolletta Fabio , Antonio Granata , Traina Mario 
Published: January 2021

Abstract
Background and study aims The therapeutic role of endoscopic ultrasound (EUS) evolved in recent decade,s opening a new chapter in the field of endoscopic biliary drainage (BD). EUS-BD has emerged as a new mini-invasive technique for neoplastic jaundice not amenable to endoscopic retrograde cholangiopancreatography (ERCP). The primary study aims were to assess the clinical efficacy of EUS-BD using an electrocautery-enhanced lumen apposing metal stent (ECE-LAMS) in patients with malignant biliary obstruction with failed\unfeasible ERCP and the adverse event (AE) rate. The secondary aims were to evaluate the technical success and incidence of jaundice recurrence.
Patients and methods Data from All patients referred to our tertiary-care Institute with obstructive jaundice due to unresectable malignant distal biliary stricture and unfeasible\failed ERCP, were prospectively recorded from January 2015 to February 2018. The procedures were performed by a single-step ECE-LAMS (AXIOS-EC, Boston Scientific) placement, from the upper gut lumen to the biliary tree, for definitive biliary decompression.
Results Twenty-one patients were consecutively enrolled. Mean pre-procedure common bile duct diameter was 16 mm and the bilirubin level was 13.9 mg/dL (range 3.8–29.5). LAMS was positioned from the duodenal bulb (n = 19) to gastric antrum (n = 2). We registered a 100 % of technical and clinical success. No AEs occurred. We observed a single case of delayed AE consisting of a buried LAMS, which was successfully resolved endoscopically.
Conclusions Despite the limits of being non-comparative, our study shows outcomes in a homogeneous population in terms of indications and technique. EUS-BD with dedicated ECE-LAMS is associated with extremely good clinical efficacy and safety and can be considered as an alternative in cases of failed/unfeasible ERCP.
Capsule endoscopy transit-related indicators in choosing the insertion route for double-balloon enteroscopy: a systematic review
Authors: Cortegoso Valdivia Pablo , Skonieczna-Żydecka Karolina , Pennazio Marco , Rondonotti Emanuele , Marlicz Wojciech , Toth Ervin , Koulaouzidis Anastasios 
Published: January 2021

Abstract
Background and study aims When capsule endoscopy (CE) detects a small bowel (SB) target lesion that may be manageable with enteroscopy, the selection of the insertion route is critical. Time- and progression-based CE indices have been proposed for localization of SB lesions. This systematic review analysed the role of CE transit indicators in choosing the insertion route for double-balloon enteroscopy (DBE).
Methods A comprehensive literature search identified papers assessing the role of CE on the choice of the route selection for DBE. Data on CE, criteria for route selection, and DBE success parameters were retrieved and analyzed according to the PRISMA statement. Risk of bias was assessed through the STROBE assessment. The primary outcome evaluated was DBE success rate in reaching a SB lesion, measured as the ratio of positive initial DBE to the number of total DBE.
Results Seven studies including 262 CEs requiring subsequent DBE were selected. Six studies used time-based indices and one used the PillCam Progress indicator. SB lesions were identified and insertion route was selected according to a specific cut-off, using fixed landmarks for defining SB transit except for one study in which the mouth-cecum transit was considered. DBE success rate was high in all studies, ranging from 78.3 % to 100 %. Six of seven studies were high quality.
Conclusions The precise localization of SB lesions remains an open issue, and larger studies are required to determine the most accurate index for selecting the DBE insertion route. In the future, 3 D localization technologies and tracking systems will be essential to accomplish this tricky task.
Evaluation eines integrierten OP-Saals auf Basis offener Standards in der Cochlea-Implantat-Chirurgie
Authors: Weber-Chüo Teresa , Rockstroh Max , Franke Stefan , Hofer Mathias , Dietz Andreas , Neumuth Thomas , Pirlich Markus 
Published: January 2021

Zusammenfassung
Hintergrund Die zunehmende Digitalisierung in der Chirurgie macht die Entwicklung moderner Operationskonzepte notwendig. Dabei werden neue Ansätze der Systemvernetzung und Integration auf Basis offener Standards der medizinischen Geräte verfolgt.
Methodik Gemeinsam mit dem Innovationszentrum für Computerassistierte Chirurgie (ICCAS) konnte die Demonstration eines integrierten OP-Saals am Beispiel der Cochlea-Implantation durchgeführt werden. Evaluiert wurden das präoperative Management, die intraoperativen Prozeduren sowie die postoperative Dokumentation von insgesamt n = 30 Studienteilnehmern (2 Gruppen). Neben der Erhebung objektiver Parameter kamen qualitative Fragebögen und quantitative, intervallskalierte Fragen zur Anwendung.
Ergebnisse Präoperativ wurde die digitale Präsentation klinischer Daten der Patienten von beiden Gruppen als hilfreich angesehen (Gruppe 1: Median = 5, Gruppe 2: Median = 4). Dies gilt auch für die personalisierten OP-Einstellungen, die intraoperativen Darstellungsmöglichkeiten sowie die dynamische, Operateur-zentrierte Visualisierung (Median = 4). Ähnlich positive Schlussfolgerungen wurden für die postoperative Dokumentation und die postoperative Nachsorge gezogen (Median = 4). Ein signifikanter Unterschied in der Gesamtbewertung des integrierten Operationskonzepts zwischen beiden Expertengruppen konnte nicht festgestellt werden (p > 0,05).
Schlussfolgerungen Die positiven Studienergebnisse zeigen, dass die theoretische Idee der Systemvernetzung auf der Basis offener Standards am Beispiel einer Cochlea-Implantation erfolgreich in die Praxis umgesetzt werden kann. Damit scheint der intelligente „Operationssaal der Zukunft“ keine fiktive Idee mehr zu sein, sondern ein realistisches Abbild der modernen chirurgischen Medizin.
A tungsten external heater for BX90 diamond anvil cells with a range up to 1700 K
Authors: Yan J. , Doran A. , MacDowell A. A. , Kalkan B. 
Published: January 2021

Resistive heating of a sample in a diamond anvil cell (DAC) can generate a homogeneous temperature field across the sample chamber with reliable temperatures measured by a thermocouple. It is of importance in experiments aiming at exploring phase diagrams and quantifying thermoelastic properties of materials. Here, we present a ring-heater design developed for BX90 diamond anvil cells (DACs). It is made of a ring-shaped aluminum oxide holder hosting a tungsten wire coil inside and coupled with Ar + 2% H2 gas to prevent oxidation during experiment. This modular plug-and-play design enables in situ studies of samples via x-ray diffraction up to a temperature of 1700 K. Temperature in the BX90 sample volume as measured through a thermocouple was calibrated using the melting point of gold. As an application of this design, we report the thermal expansion coefficient of MgO at 9.5(1) GPa.
The microwave absorption properties of Y2Fe16Si@MOF and Y2Fe16Si@GO composites
Authors: Wang Yuankang , Liu Zhou , Zhang Pengyu , Cai Kunting , Yang Wenyun , Han Jingzhi , Liu Shunquan , Wang Changsheng , Zou Ruqiang , Yang Jinbo 
Published: January 2021

With the development in communication technology, severe electromagnetic wave radiation pollution has been created, resulting in electromagnetic interference and health hazards. Thus, materials with excellent microwave absorbing properties have become an urgent need. Magnetic particles with core-shell structures are widely used as microwave absorbers due to their high magnetic loss, little eddy current effect, and tunable dielectric properties. Herein, carbonized Metal-Organic Framework (MOF), and Graphene Oxide (GO) are used to coat the Y2Fe16Si (YFeSi) magnetic powders to form YFeSi@MOF and YFeSi@GO core-shell structures. Their microwave absorption properties are studied. The reflection loss (RL) of YFeSi@MOF can reach -19.2dB@15.1GHz under 1.4 mm thickness with an effective bandwidth of 4.7 GHz, and the reflection loss of YFeSi@GO can reach -18.3dB@16.2GHz under 1.6 mm thickness with an effective bandwidth of 3.9 GHz.
Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis
Authors: Price Nathan L. , Zhang Xinbo , Fernández-Tussy Pablo , Singh Abhishek K. , Burnap Sean A. , Rotllan Noemi , Goedeke Leigh , Sun Jonathan , Canfrán-Duque Alberto , Aryal Binod , Mayr Manuel , Suárez Yajaira , Fernández-Hernando Carlos 
Published: January 2021

Significance
Prior work has suggested that the ability of miR-33, a microRNA involved in regulation of lipid metabolism, to regulate liver function underlies its effects on obesity and/or atherosclerosis. In this work, we selectively remove miR-33 from the liver and demonstrate that, unlike mice globally deficient for miR-33, mice lacking miR-33 in the liver are not predisposed to diet-induced obesity and are actually protected from hepatic insulin resistance and fibrosis. While loss of liver miR-33 increases circulating high-density lipoprotein and increases reverse cholesterol transport in mice on a chow diet, it is not sufficient to decrease atherosclerotic plaque burden under hyperlipidemic conditions where hepatic miR-33 is already repressed. This information will help improve efforts to develop novel therapies against cardiometabolic diseases.
Virus-like insertions with sequence signatures similar to those of endogenous nonretroviral RNA viruses in the human genome
Authors: Kojima Shohei , Yoshikawa Kohei , Ito Jumpei , Nakagawa So , Parrish Nicholas F. , Horie Masayuki , Kawano Shuichi , Tomonaga Keizo 
Published: January 2021

Significance
Ancient animals left diverse physical fossil records from which we can deduce that species with extraordinary features once populated our planet. By infecting germlines, some ancient viruses deposited genetic fossil records. However, inferring that a sequence is a viral fossil has so far required homology to circulating viruses. We developed a method to recognize viral fossils that do not closely resemble known viruses. Rather than homology, we detected sequence patterns of fossilized and modern RNA viruses that distinguish them from human sequences. Our results indicate that as-yet-undiscovered fossils from unknown viruses remain hidden in animal genomes. These relics of the ancient virosphere, including sequences reported here, will expand our knowledge about the diversity of ancient viruses and also our genomes.
Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial)
Authors: Chen Li , Zhu Hong-Ming , Li Yan , Liu Qi-Fa , Hu Yu , Zhou Jian-Feng , Jin Jie , Hu Jian-Da , Liu Ting , Wu De-Pei , Chen Jie-Ping , Lai Yong-Rong , Wang Jian-Xiang , Li Juan , Li Jian-Yong , Du Xin , Wang Xin , Yang Ming-Zhen , Yan Jin-Song , Ouyang Gui-Fang , Liu Li , Hou Ming , Huang Xiao-Jun , Yan Xiao-Jing , Xu Dan , Li Wei-Ming , Li Deng-Ju , Lou Yin-Jun , Wu Zheng-Jun , Niu Ting , Wang Ying , Li Xiao-Yang , You Jian-Hua , Zhao Hui-Jin , Chen Yú , Shen Yang , Chen Qiu-Sheng , Chen Yù , Li Jian , Wang Bing-Shun , Zhao Wei-Li , Mi Jian-Qing , Wang Kan-Kan , Hu Jiong , Chen Zhu , Chen Sai-Juan , Li Jun-Min 
Published: January 2021

Significance
The APL2012 trial is currently the largest randomized, multicenter clinical study of APL based on ATRA-ATO treatment with risk stratification. We enrolled 855 newly diagnosed APL patients during December 2012 to December 2017 for careful follow-up. All patients received ATRA-ATO–based protocols for remission induction. At the consolidation phase, the key part of the trial, ATO was used to replace or reduce chemotherapy in a risk-stratified way. Patients were then treated with ATRA-ATO as maintenance. The results indicated not only the noninferiority of ATO compared to intensive chemotherapy in survival but also an advantage in adverse effects. The trial provides support for the ATO regimen as a standard for making further refinements in the treatment of this highly curable disease.
Improving second language reading comprehension through reading strategies
Authors: Yapp Deborah June , de Graaff Rick , van den Bergh Huub 
Published: January 2021

AbstractEffective readers consciously or unconsciously use reading strategies to help them process information on what they read. All readers can benefit from reading strategy instruction but, empirical research on which strategies are effective is lacking. Less is known about reading strategy effectiveness in a second language (L2). This meta-analysis of 46 L2 reading strategy studies analysed ten reading strategies, also in combination with a range of pedagogical approaches, and found an overall mean effect size of0.91,underscoring the benefits of multi strategy teaching. Effect sizes were calculated for each strategy, as well as the combination of strategy with approach, instructor type, intervention duration and type of test used. Some strategies were more effective than others. Also, differences in effect sizes are dependent on the approach used. Some pedagogical approaches are effective for some strategies but not with all. We recommend further research in L2 reading strategy interventions and instruction.
Eye-tracking as a window into assembled phonology in native and non-native reading
Authors: Martin Katherine I. , Juffs Alan 
Published: January 2021

AbstractThe past 30 years of reading research has confirmed the importance of bottom-up processing. Rather than a psycholinguistic guessing game (Goodman, 1967), reading is dependent on rapid, accurate recognition of written forms. In fluent first language (L1) readers, this is seen in the automatic activation of a word’s phonological form, impacting lexical processing (Perfetti & Bell, 1991;Rayner, Sereno, Lesch & Pollatsek, 1995). Although the influence of phonological form is well established, less clear is the extent to which readers are sensitive to thepossiblepronunciations of a word (Lesch & Pollatsek, 1998), derived from the varying consistency of grapheme-to-phoneme correspondences (GPCs) (e.g., although ‘great’ has only one pronunciation, [ɡɹeɪt], the grapheme <ea> within it has multiple possible pronunciations: [i] in [plit] ‘pleat’, [ɛ] in [bɹɛθ] ‘breath’;Parkin, 1982). Further, little is known about non-native readers’ sensitivity to such characteristics. Non-native readers process text differently from L1 readers (Koda & Zehler, 2008;McBride-Chang, Bialystok, Chong & Li, 2004), with implications for understanding L2 reading comprehension (Rayner, Chace, Slattery & Ashby, 2006). The goal of this study was thus to determine whether native and non-native readers are sensitive to the consistency of a word’s component GPCs during lexical processing and to compare this sensitivity among readers from different L1s.
Interplay between perceived cross-linguistic similarity and L2 production
Authors: Georgiou Georgios 
Published: January 2021

Abstract
The present study aims to investigate the relationship between perceived cross-linguistic similarity and second language
(L2) production. To this purpose, Egyptian Arabic learners of Greek in Cyprus who took part in a previous cross-linguistic perceptual study,
completed a production test with respect to the Cypriot Greek vowels. The findings showed that perceived cross-linguistic similarity was
linked with L2 production since along with the consideration of first language (L1)-L2 acoustic differences, it predicted most of the L2
vowel productions. Also, many L2 vowels were considerably longer than the corresponding L1 vowels. This can be interpreted as an L1 transfer
since Egyptian Arabic vowels are longer in duration than the Cypriot Greek vowels. An interesting finding was that the production of the L2
vowels had only partial overlap with the productions of the L1 vowels, a finding that provides support for the hypotheses of the Speech
Learning Model.
SAY-complementizers and indexical shift in Poshkart Chuvash
Authors: Knyazev Mikhail 
Published: January 2021

AbstractAlthough SAY-complementizers have been extensively documented, the question of theformsused in this function and their specific properties has received less attention. The paper focuses on the complementizertenine(an action nominalization of SAY), which is used with communicative reception verbs (‘hear’, ‘read’, etc.), in a dialect of Chuvash (Turkic). The main puzzle concerns the difference betweentenineand the more general complementizerteze(the same-subject converb of SAY) with respect to the controller of shifted first person (namely,teze, but nottenine, disallows non-subject controllers). An account of this restriction based on three independent language-specific constraints is offered. An alternative account is discussed wherebytenine(andteze) aresynchronicallynon-finite forms of SAY. The findings highlight the importance of the form of the complementizer as well as of the choice of controller for shifted 1st person in SAY-based complementation and extend the typological parameters of indexical shift.
Rheumatoid arthritis relapse in patients with other iatrogenic immunodeficiency-associated lymphoproliferative disorders and its treatment
Authors: Nagafuchi Hiroko , Goto Yutaka , Suzuki Shotaro , Sakurai Keiichi , Imamura Mitsuru , Suzuki Takeshi , Yamasaki Yoshioki , Shibata Tomohiko , Kawahata Kimito 
Published: January 2021

AbstractObjectivesRheumatoid arthritis (RA) in patients undergoing immunosuppressive therapy (IS) is sometimes involved with other iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPD). We aimed to clarify the effects of LPD treatment on RA and the current status of RA treatment options after LPD onset and subsequent IS withdrawal.MethodsWe retrospectively analyzed data of patients who had RA with LPD and examined the relationship between LPD course and RA treatment as well as that between RA relapse and LPD treatment.ResultsLPD patients were categorized into two groups: patients who regressed spontaneously (n = 19) and those who needed chemotherapy (n = 12). The chemotherapy group had significantly less RA relapse than the spontaneous regression group (p = .041). RA almost relapsed early in the spontaneous regression group and needed treatment for RA. Chemotherapy with rituximab prevented long-term RA relapse, and RA did not relapse for long even after rituximab monotherapy. The total dose of rituximab in monotherapy correlated with the time to RA relapse. Six patients with RA relapse received biologics and had no LPD relapse for more than 1 year.ConclusionsRituximab in chemotherapy for LPD may help prevent RA relapse with LPD. Large-scale studies are required in the future for verification.
Recoverable self-cleaning surface formed by nanostructured microcapsules encapsulating hydrophobic agent
Authors: Park Dong Hyeok , Nguyen Xuan Don , Jeon Hyeong Jin , Go Jeung Sang 
Published: January 2021

Abstract
A recoverable self-cleaning surface is studied by coating the nanostructured core–shell microcapsules like a chestnut bur. The microcapsules encapsulate the hydrophobic agent so that when they are broken by mechanical damage, it is released and functions to recover the loss of the self-cleaning performance. The core–shell droplets encapsulating the hydrophobic agent are generated continuously by introducing immiscible fluids into a multi-coaxial microfluidic channel platform and cured by UV irradiation to be polymerized. The control of the size and shell thickness of the microcapsules, and the volume of the hydrophobic agent are examined. Also, the nanostructures on the surface of the microcapsules are obtained by the polyaniline process for additional increase in roughness. The critical breakage forces of the microcapsules are measured for increasing the shell thickness. Finally, the nanostructured microcapsule surface is fabricated on a glass substrate and the water contact angle is measured to determine the self-cleaning performance. Also, its recovery of the self-cleaning performance surface from the mechanical damage is demonstrated. The formation of the recoverable self-cleaning surface by coating enables to apply for a large scale and arbitrary curved surface.
Tapered racetrack microring resonator for single nanoparticle detection
Authors: Bag Saawan K , Sinha Rajat K , Wan Meher , Varshney S K 
Published: January 2021

Abstract
Rapid detection of a single nanoparticle has always been challenging and demanding. Several methods and approaches have been employed over the last few years. In this work, we have devised an integrated photonic platform to detect a single nanoparticle (NP) such as gold (Au) nanoparticle. The proposed platforms make use of a racetrack micro-ring resonator where a small region in the lower arm (non-coupled) of the resonator has been tapered to enhance the evanescent field strength many folds, which enhances the sensitivity of the device. Numerical simulations have been performed using finite difference time domain that reveal the splitting of a resonant mode in the presence of Au nanoparticle (AuNP) of radius 100 nm. The proposed approach has the capability to distinguish between different sizes and numbers of NPs. We have also studied the effect of assorted NPs in the vicinity of the tapered region. Numerical results also confirm the unique potentiality to detect NPs even if they are not adjacent to waveguide surface as well detection of a single NP of infinitesimally small size. We believe that the proposed architecture may pave a pivotal role in the sensing of biological objects such as novel viruses whose size is similar to the size of AuNP as studied in this work.