bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persuasion by Design? Design Theory Between Aesthetics and Rhetoric
Authors: Knape Joachim 
Published: October 2021

Abstract
This article deals primarily with object design from a production-theoretical perspective. It is focused on the question of the rhetorical achievement of design, i.e., its persuasiveness, which was already discussed by Buchanan and Krippendorf in 1985. To this day, the relationship between aesthetic and rhetorical calculuses in the design process is controversial in theoretical discussion. The solution to the problem: Aesthetics and rhetoric combine in the appeal structure (1) at the moment of creation of design and (2) at the moment of the user's decision for an object. In these processes, the design argument results from the combination of aestheticized gestalt and rhetorical appeal of an object.
(De)Signing Authority: The Indexical Dimension of Typography in Academic Communication
Authors: Spitzmüller Jürgen 
Published: October 2021

Abstract
Graphics in scientific communication are not just a means to elegantly convey, condense, or systematize “facts.” As any form of communication, they are bound to, or enregistered in, the discursive context of previous uses. Graphics, thus, do not only visualize information (in an iconic or symbolic way), they also contextualize (i.e., index) the practices, communities, and genres of particular fields and thereby serve as effective emblems of scholarly identity. This article elaborates on the indexical or emblematic dimension of academic graphic design. Drawing on sociolinguistic theory of social positioning and identification, it will be argued how graphic design is a disciplinary practice in the double sense of the word.
Lagged teleconnections of climate variables identified via complex rotated Maximum Covariance Analysis
Authors: Rieger Niclas , Corral Álvaro , Olmedo Estrella , Turiel Antonio 
Published: October 2021

AbstractA proper description of ocean-atmosphere interactions is key for a correct understanding of climate evolution. The interplay among the different variables acting over the climate is complex, often leading to correlations across long spatial distances (teleconnections). In some occasions, those teleconnections occur with quite significant temporal shifts that are fundamental for the understanding of the underlying phenomena but which are poorly captured by standard methods. Applying orthogonal decomposition such as Maximum Covariance Analysis (MCA) to geophysical data sets allows to extract common dominant patterns between two different variables, but generally suffers from (i) the non-physical orthogonal constraint as well as (ii) the consideration of simple correlations, whereby temporally offset signals are not detected. Here we propose an extension, complex rotated MCA, to address both limitations. We transform our signals using the Hilbert transform and perform the orthogonal decomposition in complex space, allowing us to correctly correlate out-of-phase signals. Subsequent Varimax rotation removes the orthogonal constraints, leading to more physically meaningful modes of geophysical variability. As an example of application, we have employed this method on sea surface temperature and continental precipitation; our method successfully captures the temporal and spatial interactions between these two variables, namely for (i) the seasonal cycle, (ii) canonical ENSO, (iii) the global warming trend, (iv) the Pacific Decadal Oscillation, (v) ENSO Modoki and finally (vi) the Atlantic Meridional Mode. The complex rotated modes of MCA provide information on the regional amplitude, and under certain conditions, the regional time lag between changes on ocean temperature and land precipitation.
An experience in treatment of neurologically silent clival chordoma mimicking a nasopharyngeal tumor
Authors: Lin Jung-Ting , Hsu Heng-Jui 
Published: October 2021

Cranial chordoma is a rare neoplasm that is challenging to both diagnose and manage. We present our experience in treating a case of clival chordoma mimicking a nasopharyngeal mass without any signs of cranial deficits or intracranial insult. Management was comprised of endoscopic transnasal debulking surgery followed by radiotherapy. However, we failed to achieve an oncologic outcome due to the development of lethal central nervous system and respiratory infections 1 month after the surgery.
Comparison of stent related symptoms in patients taking mirabegron, solifenacin, or tamsulosin: A double blinded randomized clinical trial
Authors: Chandna Abhishek , Kumar Santosh , Parmar Kalpesh M , Sharma Aditya P , Devana Sudheer K , Mete Uttam K , Singh Shrawan K 
Published: October 2021

Background: The present study aims to assess the efficacy of mirabegron, a novel beta-3 agonist for ameliorating stent related symptoms (SRSs) as compared to tamsulosin and solifenacin. Methods: Total of 150 patients undergoing ureteral stent placement following ureteroscopic lithotripsy, percutaneous nephrolithotomy, or laparoscopic/robotic pyeloplasty were randomized in 1:1:1 fashion to receive mirabegron 50 mg (group A), solifenacin 5 mg (group B), and tamsulosin 0.4 mg (group C) OD respectively. Patients were followed at POD10 (I visit), 4 weeks (II visit) after surgery, and 2 weeks post-stent removal. Validated vernacular version of ureteric stent symptoms questionnaire (USSQ) was administered to the patients at each visit. Results: Out of 150 patients randomized, 123 patients (A; n = 41, B; n = 40, and C; n = 42) completed the study. The groups were comparable in terms of urinary index score of USSQ at I and II visits ( p = 0.119 and 0.076, respectively). A lower proportion of patients in group B experiencing bodily pain at II visit ( p = 0.039), however, pain scores were comparable. Significantly lower general health index scores were observed in group A at I visit and over 4 weeks ( p = 0.007). No significant differences were observed in other domains of USSQ. Age, sex, and surgical procedure undertaken did not significantly impact the scores in various USSQ domains. Conclusion: Mirabegron demonstrates comparable benefit in alleviating SRSs with better general health indices and may be an effective alternative for SRSs, especially when tamsulosin or solifenacin are contra-indicated or poorly tolerated.
Eptacog Beta for Bleeding Treatment and Prevention in Congenital Hemophilia A and B With Inhibitors: A Review of Clinical Data and Implications for Clinical Practice
Authors: Ciolek Alana M. , Arnall Justin , Moore Donald C. , Palkimas Surabhi , Der-Nigoghossian Julie , Dane Kathryn 
Published: October 2021

Objective: To review the pharmacology, dosing and administration, safety, clinical efficacy, and role of eptacog beta in the treatment of congenital hemophilia with inhibitors. Data Sources: A literature search of PubMed (1966 to August 2021) was conducted using the keywords eptacog beta, recombinant FVII, and hemophilia. Study Selection and Data Extraction: All relevant published articles and prescribing information on eptacog beta for the treatment of congenital hemophilia with inhibitors were reviewed. Data Synthesis: Eptacog beta is a novel recombinant activated factor VII (rVIIa) product that demonstrated efficacy in controlling bleeding and associated pain in patients with hemophilia A or B with inhibitors. Eptacog beta has limited Food and Drug Administration–approved and off-label indications compared with other bypassing agents (BPAs; activated prothrombin complex concentrates [aPCC; eptacog alfa]). Eptacog beta costs less than eptacog alfa, but still more than aPCCs. Relevance to Patient Care and Clinical Practice: This review provides insight into the role of eptacog beta for treatment of congenital hemophilia with inhibitors and reviews important health system formulary considerations for available BPAs. Conclusions: Eptacog beta is more cost-effective than eptacog alfa and, as such, may become the preferred rVIIa formulary product. However, eptacog alfa availability remains necessary for the treatment of disorders where eptacog beta has limited data. aPCC should remain the first-line BPA for the treatment of bleeding in patients with inhibitors with no contraindications to use because of its equivocal efficacy and safety and in light of the magnitude of cost savings associated with this strategy.
Humoral immune response after COVID-19 in multiple sclerosis: A nation-wide Austrian study
Authors: Bsteh Gabriel , Dürauer Sophie , Assar Hamid , Hegen Harald , Heschl Bettina , Leutmezer Fritz , Pauli Franziska Di , Gradl Christiane , Traxler Gerhard , Zulehner Gudrun , Rommer Paulus , Wipfler Peter , Guger Michael , Höftberger Romana , Enzinger Christian , Berger Thomas 
Published: October 2021

Background: Knowledge on immunity after SARS-CoV-2 infection in patients with multiple sclerosis (pwMS) and the impact of disease-modifying treatment (DMT) is limited. Objective: To evaluate degree, duration and potential predictors of specific humoral immune response in pwMS with prior COVID-19. Methods: Anti-SARS-CoV-2 antibody testing was performed in pwMS with PCR-confirmed diagnosis of symptomatic COVID-19 from a nation-wide registry. Predictors of seropositivity were identified by multivariate regression models. Results: In 125 pwMS (mean age = 42.4 years (SD = 12.3 years), 70% female), anti-SARS-CoV-2 antibodies were detected in 76.0% after a median of 5.2 months from positive PCR. Seropositivity rate was significantly lower in patients on IS-DMT (61.4%, p = 0.001) than without DMT or immunomodulatory DMT (80.6%; 86.0%, respectively). In multivariate analysis, IS-DMT was associated with reduced probability of seropositivity (odds ratio (OR): 0.51; 95% confidence interval (95% CI): 0.17–0.82; p < 0.001). Predefined subgroup analyses showed marked reduction of seropositivity in pwMS on rituximab/ocrelizumab (OR 0.15; 95% CI: 0.05–0.56; p < 0.001). Rate of seropositivity did not change significantly over 6 months. Conclusions: Humoral immunity is stable after SARS-CoV-2 infection in MS, but is reduced by immunosuppressive DMT, particularly anti-CD20 monoclonal antibodies. This provides important evidence for advising pwMS as well as for planning and prioritizing vaccination.
Strength index analysis of concrete with large size recycled aggregate based on back propagation neural network
Authors: Li Tan , Xiao Jianzhuang , Singh Amardeep 
Published: October 2021

A back propagation (BP) neural network (NN) model was used to analyze the relationship between the cube compressive strength and various strength indicators of concrete with large-sized recycled aggregates (LSRA) (80 mm maximum size). Factors such as strength and replacement rate of recycled aggregates were used as input parameters to establish the neural network model. The BP-NN model was optimized by analyzing the influence and sensitivity of each parameter in the model. Then the mechanical properties of concrete with LSRA were predicted. Results showed that the strength of new concrete had a more significant impact on the strength of recycled concrete with LSRA, followed by the strength of old concrete. While considering all the factors, including the mechanical strength and the replacement ratio regarding the maximum utilization of RA, the 30% incorporation rate was suggested as an ideal incorporation rate.
Hybrid artificial intelligence-based inference models for accurately predicting dam body displacements: A case study of the Fei Tsui dam
Authors: Cheng Min-Yuan , Cao Minh-Tu , Huang I-Feng 
Published: October 2021

Surveillance is a critical activity in monitoring the operation condition and safety of dams. This study reviewed the historical monitoring data of the Fei Tsui dam to determine possible influential factors for the dam body displacement and then evaluated the influencing degree of these factors by using correlation analysis. Thus, the key influential factors were identified objectively and further chosen as the input variables for numerous artificial intelligence (AI)-based inference models, including single machine learning techniques (support vector machine (SVM), artificial neural networks) and hybrid AI models. The models were trained and tested with 4722 real data retrieved in 11 years from the monitoring devices installed on elements of the dam, and then generated their respective inferred dam body displacement values. The results revealed that the adaptive time-dependent evolutionary least squares SVM model had the greatest performance by providing the lowest values of prediction errors in terms of mean absolute percentage error (MAPE = 8.14%), root mean square error (RMSE = 1.08 cm), and coefficient of determination (R = 0.993). The analysis results endorsed that the hybrid AI model could be an efficient tool to early produce accurate warnings of the dam displacements.
Integrating Safety and Health Promotion in Workplaces: A Scoping Review of Facilitators, Barriers, and Recommendations
Authors: Biswas Aviroop , Begum Momtaz , Van Eerd Dwayne , Johnston Heather , Smith Peter M. , Gignac Monique A. M. 
Published: October 2021

Background Growing evidence supports the integration and coordination of occupational health and safety and workplace health promotion activities instead of these coexisting as siloed efforts. Identifying implementation challenges and how these can be overcome is an important step to achieving truly integrated worker health efforts. We conducted a scoping review to identify the barriers and facilitators to integrated worker health approaches and described recommendations for implementing these efforts. Method Peer-reviewed articles and gray literature from 2008 to 2019 were searched from the following electronic databases: EMBASE, Ovid Medline, PsycINFO, and ABI/INFORM. References from relevant articles and key informant suggestions also were collected. Data were extracted from documents if they focused on the occupational health and safety and health promotion of workers and described outcomes associated with integrated worker health approaches or outlined considerations relevant to the implementation of these approaches. Results Fifty-one documents met the inclusion criteria and were reviewed. Barriers and facilitators to implementing integrated worker health approaches were found at the extraorganizational, organizational, worker, and program levels, with limited resource availability the most reported barrier and support from leadership the most reported facilitator. Ten broad recommendations were identified and highlighted gaining leadership support, demonstrating leadership commitment, developing worker-centric approaches, and building capacity for workers. Conclusion In reviewing the literature, we found clear and consistent recommendations relevant for integrated worker health approaches. Further research is needed to better understand how these recommendations apply to diverse workforces and organizations with varied resources.
Introduction of 3D Printing in a German Municipal Hospital—Practice Guide for CMF Surgery
Authors: Gleissner H , Castrillon-Oberndorfer G , Gehrlich St 
Published: October 2021

Study Design: This study aimed to introduce 3D printing in a municipal hospital to improve the treatment of craniomaxillofacial patients and optimize costs and operating time. Thus we describe the implementation of low-cost in-house 3D printing to facilitate orbital- and mandible reconstruction in CMF surgery. Moreover, we address legal requirements, safety at work, fire- and data protection. Finally, we want to share our experiences using 3D printing and point out its advantages in providing better patient care. Methods: We outline the setup of in-house 3D printing and focus on obeying German health care regulations. We based our approach on a fused deposition modeling 3D printer and free software. As proof of concept, we treated 4 cases of severe orbital trauma and 1 case of mandibular reconstruction. We printed a 3D patient-specific model for each case and adapted a titanium mesh implant, respectively, a titanium reconstruction plate before performing the surgery. Results: Our approach reduced costs, duration of anesthesia, operating time, recovery time, and postoperative swelling and increased the revenue. Functional outcome in orbital reconstruction like eye movement and double vision, was improved compared to the conventional technique. No severe complications like loss-of-vision or surgical revision occurred. Likewise, mandibular reconstruction showed no plate loosening or plate fracture. Conclusion: The implementation of cost-efficient 3D printing resulted in successful patient treatment with excellent outcomes. Our practice guide offers a 3D printing workflow and could be adapted to fit the needs of other specialties like neurosurgery, orthopedic surgery as well.
Challenges of Singapore’s First Acute Geriatric Isolation Facility During the COVID-19 Pandemic
Authors: Chong Yap Bernard Kok , Del Valle Espeleta Wrenzie , Sinnatamby Savithri , Li Fuyin , Liza Bantilan Anna , Ong Siew Yit , Png Gek Kheng , Koh Jansen Meng Kwang , Koh Lip Hoe , Goh Kiat Sern 
Published: October 2021

Aim The COVID-19 pandemic has seen hospitals isolating suspect cases. Geriatric populations are at a risk of severe COVID-19 disease and often present with concomitant geriatric syndromes requiring holistic interdisciplinary care. However, isolation of older people poses challenges to care delivery. This study shares the experience of Singapore’s first acute geriatric isolation facility geriatric PARI (Pneumonia-Acute Respiratory Infection) ward and describes the geriatric-related outcomes and pitfalls in care delivery. Methods This is a retrospective cross-sectional study performed in 7 negative pressure isolation rooms in an acute care public hospital in Singapore. 100 patients admitted consecutively to the geriatric PARI ward were included. Patient demographics, presenting symptoms and geriatric-related adverse outcomes associated with hospitalisation were collected and analysed. Results Patients’ mean age was 86.4 years (standard deviation [SD]: 6.8) with significant comorbidities being hypertension (81%), hyperlipidaemia (74%) and renal disease (70%). 51% of patients had dementia and 24% had behaviour and psychological symptoms of dementia (BPSD). 27% of patients presented atypically with delirium and 15% presented with a fall. Delirium was associated with restraint use (OR: 3.88; p-value 0.01). Falls rate was 1.64 per 1000 occupied bed. 1 patient screened positive for COVID-19. Conclusions The geriatric PARI ward is essential for curbing nosocomial transmission of COVID-19. This is important in the older people with comorbidities who are more likely to develop morbidity and mortality. Our study reveals challenges in delivering person-centred care to the older patients in isolation rooms, especially in the management of delirium and falls prevention. Innovative strategies should be developed to minimise isolation-related adverse outcome.
Residual Lesion Diagnostics in Pediatric Postcardiotomy Extracorporeal Membrane Oxygenation and Its Outcomes
Authors: Soynov Ilya A. , Kornilov Igor A. , Kulyabin Yuriy Y. , Zubritskiy Alexey V. , Ponomarev Dmitry N. , Nichay Nataliya R. , Murashov Ivan S. , Bogachev-Prokophiev Alexander V. 
Published: October 2021

Background: To assess the impact of diagnostic procedures in identifying residual lesions during extracorporeal membrane oxygenation (ECMO) on survival after pediatric cardiac surgery. Methods: Between January 2012 and December 2017, 74 patients required postcardiotomy ECMO. Patients were retrospectively divided into 2 groups: Group I underwent only echocardiography ([echo only] 46 patients, 62.2%) and group II (echo+) underwent additional diagnostic tests (ie, computed tomography [CT] or cardiac catheterization; 28 patients, 37.8%). Propensity score matching was used to balance the 2 groups by baseline characteristics. Results: Two equal groups (28 patients in each group) were formed by propensity score matching. Fourteen (50%) patients in the echo-only group and 20 (71%) patients in the echo+ group were successfully weaned from ECMO ( P = .17). Four (14.3%) patients survived in the echo-only group and 15 (53.5%) patients survived in the echo+ group ( P = .004). Patients in the echo+ group had a lower chance of dying compared to the echo-only group (odds ratio, 0.14.6; 95% CI, 0.039-0.52; P = .003). The residual lesions, which may have served as a mortality factor, were found by autopsy in 8 (40%) patients in the echo-only group, while none were found in the echo+ group ( P = .014). Conclusions: The autopsies of patients who died despite postcardiotomy ECMO support showed that in 40% of cases that had been investigated by echo only, residual lesions that had not been detected by echocardiography were present. The cardiac catheterization and CT during ECMO are effective and safe for identifying residual lesions. Early detection and repair of residual lesions may increase the survival rate of pediatric cardiac patients on ECMO.
Surgical management of Diffuse Idiopathic Skeletal Hyperostosis (DISH) causing secondary dysphagia (Narrative review)
Authors: Bunmaprasert Torphong , Keeratiruangrong Jakkrit , Sugandhavesa Nantawit , Riew K Daniel , Liawrungrueang Wongthawat 
Published: October 2021

Objectives: To summarize the current evidence on surgical treatment for large bridging osteophytes of the anterior cervical spine from Diffuse Idiopathic Skeletal Hyperostosis (DISH). Overview of Literature: In the current review, the surgical treatment of secondary dysphagia from DISH was the most useful treatment. We propose a treatment algorithm for management of this condition because currently there are only case reports and retrospective studies available. Methods: Literature search was performed using the MeSH terms “Anterior Cervical Osteophyte,” “Diffuse Idiopathic Skeletal Hyperostosis (DISH),” and “Dysphagia” and “Treatment” for articles published between January 2000 and February 2020. PubMed search identified 117 articles that met the initial screening criteria. Detailed analysis identified the 40 best matching articles, following which the full inclusion and exclusion criteria left 11 articles for this review. Results: Incidence of secondary dysphagia was associated with DISH in elderly patients (average 65 years). The major clinical findings were dysphagia or respiratory compromise, with the most common level of bridging osteophytes of the cervical spine at C3–C5. There were 10 articles on surgical treatment involving anterior cervical osteophytectomy without fusion, 1 for multilevel cervical oblique corpectomy, 1 for anterior cervical discectomy with fusion plus plate, and 1 for anterior cervical osteophytectomy with stand-alone PEEK cage or plus plate. All the cases resulted in significant improvement without recurrence, with only 1 case having post-operative complications. Follow-up duration was 3–70.3 months. Conclusions: Surgical intervention for anterior cervical osteophytectomy appears to result in improved outcomes. However, there could be disadvantages concerning cervical spine motion if cervical osteophytectomy with cervical discectomy and fusion (ACDF) plus plate system is done.