bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis and Prophylactic Regional Nodal Irradiation in Breast Cancer Patients With the First Isolated Chest Wall Recurrence After Mastectomy
Authors: Zhao Xu-Ran , Xuan Liang , Yin Jun , Tang Yu , Sun Hui-Ru , Jing Hao , Song Yong-Wen , Jin Jing , Liu Yue-Ping , Fang Hui , Ren Hua , Chen Bo , Tang Yuan , Li Ning , Qi Shu-Nan , Lu Ning-Ning , Yang Yong , Li Ye-Xiong , Sun Bing , Wu Shi-Kai , Wang Shu-Lian 
Published: February 2021

Background and PurposeOptimal radiation target volumes for breast cancer patients with their first isolated chest wall recurrence (ICWR) after mastectomy are controversial. We aimed to analyze the regional failure patterns and to investigate the role of prophylactic regional nodal irradiation (RNI) for ICWR.Materials and MethodsAltogether 205 patients with ICWR after mastectomy were retrospectively analyzed. Post-recurrence progression-free survival (PFS) and overall survival (OS) rates were calculated by Kaplan-Meier method and the differences were compared with Log-rank test. Competing risk model was used to estimate the subsequent regional recurrence (sRR) and locoregional recurrence (sLRR) rates, and the differences were compared with Gray test.ResultsThe 5-year sRR rate was 25.2% with median follow-up of 88.6 months. Of the 52 patients with sRR, 30 (57.7%) recurred in the axilla, 29 (55.8%) in supraclavicular fossa (SC), and five (9.6%) in internal mammary nodes. Surgery plus radiotherapy was independently associated with better sLRR and PFS rates (p&lt;0.001). The ICWR interval of ≤ 4 years was associated with unfavorable sRR (p=0.062), sLRR (p=0.014), PFS (p=0.001), and OS (p=0.005). Among the 157 patients who received radiotherapy after ICWR, chest wall plus RNI significantly improved PFS (p=0.004) and OS (p=0.021) compared with chest wall irradiation alone. In the 166 patients whose ICWR interval was ≤ 4 years, chest wall plus RNI provided the best PFS (p&lt;0.001) and OS (p=0.022) compared with chest wall irradiation alone or no radiotherapy.ConclusionPatients with ICWR have a high-risk of sRR in SC and axilla. Chest wall plus RNI is recommended.
Alnus hirsuta (Spach) Rupr. Attenuates Airway Inflammation and Mucus Overproduction in a Murine Model of Ovalbumin-Challenged Asthma
Authors: Lee Ba-Wool , Ha Ji-Hye , Ji Yeongseon , Jeong Seong-Hun , Kim Ju-Hong , Lee Jihye , Park Ji-Young , Kwon Hyung-Jun , Jung Kyungsook , Kim Jong-Choon , Ryu Young-Bae , Lee In-Chul 
Published: February 2021

Alnus hirsuta (Spach) Rupr. (AH), a member of the Betulaceae family, is widely used in Eastern Asia of as a source of medicinal compounds for the treatment of hemorrhage, diarrhea, and alcoholism. In this study, we investigated the protective effects of a methanolic extract of AH branches against airway inflammation and mucus production in tumor necrosis factor (TNF)-α-stimulated NCI-H292 cells and in an ovalbumin (OVA)-challenged allergic asthma mouse model. Female BALB/c mice were injected with OVA (40 μg) and aluminum hydroxide (2 mg) on days 0 and 14 to induce allergic airway inflammation. The mice were then challenged with 1% OVA from days 21–23. Mice were treated with AH (50 and 100 mg/kg/day; 2% DMSO) or dexamethasone (positive control; 3 mg/kg/day) from days 18–23. AH treatment effectively attenuated airway resistance/hyperresponsiveness and reduced levels of T helper type 2 (Th2) cytokines, eotaxins, and number of inflammatory cells in bronchoalveolar lavage fluid, and immunoglobulin E in serums of OVA-challenged mice. In histological analysis, AH treatment significantly inhibited airway inflammation and mucus production in OVA-challenged mice. AH treatment downregulated the phosphorylation of I kappa B-alpha, p65 nuclear factor-kappa B (p65NF-κB), and mitogen-activated protein kinases with suppression of mucin 5AC (MUC5AC) in lung tissue. Moreover, AH treatment decreased the levels of pro-inflammatory cytokines and Th2 cytokines, as well as MUC5AC expression, and inhibited the phosphorylation of p65NF-κB in TNF-α-stimulated NCI-H292 cells. These results indicate that AH might represent a useful therapeutic agent for the treatment of allergic asthma.
Network Analysis to Identify Communities Among Multiple Exposure Biomarkers Measured at Birth in Three Flemish General Population Samples
Authors: Ottenbros Ilse , Govarts Eva , Lebret Erik , Vermeulen Roel , Schoeters Greet , Vlaanderen Jelle 
Published: February 2021

Introduction:Humans are exposed to multiple environmental chemicals via different sources resulting in complex real-life exposure patterns. Insight into these patterns is important for applications such as linkage to health effects and (mixture) risk assessment. By providing internal exposure levels of (metabolites of) chemicals, biomonitoring studies can provide snapshots of exposure patterns and factors that drive them. Presentation of biomonitoring data in networks facilitates the detection of such exposure patterns and allows for the systematic comparison of observed exposure patterns between datasets and strata within datasets.Methods:We demonstrate the use of network techniques in human biomonitoring data from cord blood samples collected in three campaigns of the Flemish Environment and Health Studies (FLEHS) (sampling years resp. 2002–2004, 2008–2009, and 2013–2014). Measured biomarkers were multiple organochlorine compounds, PFAS and metals. Comparative network analysis (CNA) was conducted to systematically compare networks between sampling campaigns, smoking status during pregnancy, and maternal pre-pregnancy BMI.Results:Network techniques offered an intuitive approach to visualize complex correlation structures within human biomonitoring data. The identification of groups of highly connected biomarkers, “communities,” within these networks highlighted which biomarkers should be considered collectively in the analysis and interpretation of epidemiological studies or in the design of toxicological mixture studies. Network analyses demonstrated in our example to which extent biomarker networks and its communities changed across the sampling campaigns, smoking status during pregnancy, and maternal pre-pregnancy BMI.Conclusion:Network analysis is a data-driven and intuitive screening method when dealing with multiple exposure biomarkers, which can easily be upscaled to high dimensional HBM datasets, and can inform mixture risk assessment approaches.
PTSD and Suicidal Behaviors Amongst L'Aquila 2009 Earthquake Young Survivors
Authors: Carmassi Claudia , Bertelloni Carlo Antonio , Dell'Oste Valerio , Luperini Chiara , Marazziti Donatella , Rossi Rodolfo , Dell'Osso Liliana 
Published: February 2021

Background: Post-traumatic stress disorder (PTSD) is one of the most frequent and severe psychiatric consequences of natural disasters, frequently associated with suicidality. The aim of this study was at examining the possible relationships between suicidal behaviors and full-blown or partial PTSD, in a sample of young earthquake survivors. The second aim was at investigating the specific role of PTSD symptoms on suicidality.Methods: A total of 475 young adults who survived the L'Aquila 2009 earthquake, one of the most severe Italian disasters of the last decades, were recruited and assessed after 21 months from the catastrophe. Participants were evaluated by two questionnaires assessing subthreshold psychopathology, the Trauma and Loss Spectrum Self-Report (TALS-SR) to investigate both full and partial PTSD, and two specific Mood Spectrum Self-Report (MOODS-SR) sub-domains exploring suicidality, namely suicidal ideation and suicide attempts.Results: The ensuing findings showed that suicidal ideation and suicide attempts were present, respectively, in 40 (8.4%) and 11 (2.3%) survivors. Rates of suicidal ideation were significantly more elevated in full-blown PTSD subjects (group 1), as compared with those suffering from partial (group 2) or no PTSD (group 3). Interestingly, group 2 subjects showed significantly more suicidal ideation than healthy individuals, and less than those of group 1, while the frequency of suicide attempts was similar across the three groups. Suicidal ideation was associated with higher scores in the following TALS-SR domains: grief-reactions, re-experiencing, avoidance and numbing, maladaptive coping, and personal characteristics/risk factor.Conclusions: The results of the present study support and extend previous findings on the role of PTSD symptoms in suicidality after a severe earthquake. However, as compared with available literature, they also highlight the significant impact of sub-threshold PTSD manifestations in increasing the suicide risk in survivors of a mass disaster.
DETECCIÓN DE Pseudomonas spp. EN LA BAHÍA DE CARTAGENA
Authors: Rabelo-Florez Roger Alberto , Cuadrado-Cano Bernarda Soraya , Márquez-Gómez Marco Antonio , Quintero-Caviedes Jose Ramiro , De la Rosa-Martínez Darwin 
Published: February 2021

Objetivo: El objetivo principal de esta investigación es obtener bacterias del género Pseudomona spp. con capacidad biodegradora de hidrocarburos en muestras de agua superficial de la Bahía de Cartagena de Indias. Material y Método: Diseño observacional, descriptivo, transversal y prospectivo. Se tomaron tres muestras de agua superficial de la Bahía de Cartagena de indias, se sembraron para preadaptacion y adaptación biológica de las bacterias en medio con sales minerales, ACPM 1% v/v y petróleo crudo 1% v/v, como única fuente de carbono y energía. Resultados: Las bacterias que crecieron en los medios con petróleo crudo fueron identificadas en 31 morfotipos de colonias bacterianas, de las cuales solo el 19,4% dio positivo para la presencia de Pseudomona spp., y el 80,6% restante, pertenecientes a otros grupos bacterianos. Discusión: Se evidenció un cambio de color en el agar nutritivo durante el procedimiento de aislamiento de las bacterias de la muestra 2 relacionado con la presencia de especies de Pseudomonas en especial P. aeruginosa. Conclusión: Se reporta la presencia del género de Pseudomona spp. con capacidad biodegradadora de petróleo en una de las muestras de agua recolectadas en la Bahía de Cartagena. Este estudio abre la posibilidad de futuros trabajos de bioprospección e identificación metabólica de las cepas aisladas.
Improving team coordination in primary-care settings via multifaceted team-based feedback: a non-randomised controlled trial study
Authors: Hysong Sylvia J , Amspoker Amber B , Hughes Ashley M , Lester Houston F , Svojse Erica K , Khan Kashif , Mehta Praveen , Petersen Laura A 
Published: February 2021

BackgroundCoordination is critical to successful team-based health care. Most clinicians, however, are not trained in effective coordination or teamwork. Audit and feedback (A&F) could improve team coordination, if designed with teams in mind.AimThe effectiveness of a multifaceted, A&F-plus-debrief intervention was tested to establish whether it improved coordination in primary care teams compared with controls.Design & settingCase-control trial within US Veterans Health Administration medical centres.MethodThirty-four primary care teams selected from four geographically distinct hospitals were compared with 34 administratively matched control teams. Intervention-arm teams received monthly A&F reports about key coordination behaviours and structured debriefings over 7 months. Control teams were followed exclusively via their clinical records. Outcome measures included a coordination composite and its component indicators (appointments starting on time, timely recall scheduling, emergency department utilisation, and electronic patient portal enrolment). Predictors included intervention arm, extent of exposure to intervention, and degree of multiple team membership (MTM).ResultsIntervention teams did not significantly improve over control teams, even after adjusting for MTM. Follow-up analyses indicated cross-team variability in intervention fidelity; although all intervention teams received feedback reports, not all teams attended all debriefings. Compared with their respective baselines, teams with high debriefing exposure improved significantly. Teams with high debriefing exposure improved significantly more than teams with low exposure. Low exposure teams significantly increased patient portal enrolment.ConclusionTeam-based A&F, including adequate reflection time, can improve coordination; however, the effect is dose dependent. Consistency of debriefing appears more critical than proportion of team members attending a debriefing for ensuring implementation fidelity and effectiveness.
ANALISIS KESALAHAN BAHASA DALAM PENULISAN LAPORAN TUGAS AKHIR MAHASISWA POLITEKNIK NEGERI TANAH LAUT
Authors: Budiantoro Tekad , Wijayati Titik , Karolina Karolina 
Published: February 2021

Fokus utama dari penelitian ini adalah untuk menganalisis jenis kesalahan apa saja yang terdapat pada Laporan Tugas Akhir yang ditulis oleh Mahasiswa Politeknik Negeri Tanah Laut. Penelitian tentang analisis kesalahan bahasa ini menggunakan metode deskriptif kualitatif. Subyek penelitian adalah sampel Dokumen Laporan Tugas Akhir Mahasiswa Politeknik Negeri Tanah Laut sebagai korpus dan bahan analisis, sebanyak 6 (enam) eksemplar, masing-masing 2 dari Program Studi Teknik Informatika, 2 dari Program Studi Agroindustri; dan 2 dari Program Studi Teknik Otomotif . Dalam penelitian ini akan digunakan teknik analisis wacana, seluruh data temuan ditabulasi, untuk diinfentarisir, dipilih, dan dipilah atau diklasifikasikan sesuai dengan jenis dan letak kesalahannya, baik yang bersifat fonologis, morfologis, sintaksis ataupun kesalahan yang bersifat semantis atau tata makna dan kesalahan-kesalahan lain yang terjadi. Simpulan dari hasil penelitian ini adalah menunjukkan bahwa terdapat beberapa jenis kesalahan yang terdapat pada Laporan Tugas Akhir yang ditulis oleh Mahasiswa Politeknik Negeri Tanah Laut, yakni (1) Kesalahan pada tataran fonologi; (2)Kesalahan pada tataran morfologi; (3) Kesalahan pada tataran sintaksis; (4) Kesalahan pada tataran makna. Diperlukan penelutian lebih lanjut untuk menemukan solusi yang tetap dalam mengatasi permasalahan tentang banyaknya kesalahan tata bahasa yang terdapat pada Laporan Tugas Akhir yang ditulis oleh Mahasiswa Politeknik Negeri Tanah Laut.
Cegah COVID-19 Di Era New Normal Pada KP.Sambengan
Authors: Arenawati Arenawati , Listyaningsih Listyaningsih , Anggara Yogi 
Published: February 2021

Pengabdian Kepada Masyarakat yang akan dilakukan untuk pencegahan masyarakat dalam menghadapi pandemi ini. Data yang ditunjukan oleh website resmi covid19.boyolali.go.id di kabupaten Boyolali tercatat 1330 kasus COVID-19, 55 meninggal dunia,dan 120 dirawat. Untuk di kecamatan Simo tercatat 1280 di konfirmasi positif. Dengan demikian perlu dilakukan upaya peningkatan kesadaran masyarakat tentang pencegahan penularan COVID-19 berbasis keluarga untuk membantu kesadaran masyarakat di kp.sambengan.Target sasaran pengabdian adalah Kelurahan kel. Gunung, kec. Simo, kab.
Boyolali. Dari seluruh rangkaian kegiatan pelaksanaan pengabdian masyarakat ini telah disebarkan berbagai konten digital yang sangat mudah diakses. Pengabdian pada masyarakat terintegrasi magang ini menggunakan pendekatan dengan sebagai berikut: 1) tahap perencanaan; 2) tahap persiapan; 3) tahap pelaksanaan; 4) tahap evaluasi. Dari seluruh rangkaian kegiatan pelaksanaan magang pengabdian masyarakat ini telah disosialisasikan berbagai konten meliputi digital dan non digital. Daerah sasaran yakni yakni kp.Sambengan, kel. Gunung, kec. Simo, kab. Boyolali sudah disebarluaskan poster melalui media sosial berisikan perlunya pencegahan masyarakat mengenai virus COVID-19. Kemudian siap untuk menghadapi New Normal untuk masyarakat serta kelurahan agar tetap waspada. Serta pemanfaatan poster untuk Instagram oleh para anggota pengabdi dilakukan untuk meningkatkan pencegahan dan angka kasus positif di masyarakat secara konkrit terkait COVID-19
OPTIMALISASI PERSEDIAAN BAHAN BAKU BAGI KELANCARAN PROSES PRODUKSI PADA TOKO ROTI DWI JAYA BAKERY KUPANG
Authors: Taek Bete Yohanes M M , Nursiani Ni Putu , Ndoen Wehelmina M 
Published: February 2021

This research will focus on the controlling of raw materials supply to expedite the production process.This study aims to determine and analyze the optimization of raw material supplies in the Dwi JayaBakery Kupang. The method used in this study is the EOQ (economic order quantity), Safety Stock,Re-order Point methods. The instruments used in this study were interviews, literature studies, anddocumentation. The results showed that, in ordering raw materials, Dwi Jaya Bakery still usesconventional calculations where by predicting the amount of raw materials replenishment if there isonly a small amount of supplies, and also has not applied safety stock and ROP optimally, so thatsometimes raw materials in the warehouse were lack of inventory, it indirectly affect profits from DwiJaya Bakery and which results in delays in ordering so that it can disrupt the production process.
Keywords: Optimization of Raw Material Inventory, Production Process, EOQ (Economic OrderQuantity
ANALISIS PENENTUAN LUAS PRODUKSI PADA PERUSAHAAN ROTI BANGKIT JAYA DI KOTA KUPANG
Authors: Naisoko Raimundus Ivan , Foenay Christien C , Nyoko Antonio E L 
Published: February 2021

The purpose of this study is to analyze the determination of production volume to maximize profits.This research is a quantitative research. Data analysis techniques are Forecasting and LinearProgramming (Simplex Method). The result of analysis concluded that the production volume usingLinear Programming simplex method obtained in 2019 should produce as many as 405,792,000molten chocolate bread per year and by 2020 should produce as many as 4,107,480 molten chocolatebread per year for earning maximum profit. Meanwhile, the Forecasting result is to produce 4 typesof bread as many as 6,308,240 breads in 2019 and 6,365,560 breads in 2020. In terms of profitoptimization then calculation using Linear Programming is better however considering the marketingaspect where consumers require a variety of bread flavors then calculation using forecasting method ismore recommended.
Keywords: Forecasting, Linear Programming, Optimization, Volume Production
E-Commerce in the People’s Republic of China and the Use of Neuromarketing Tools During the 2020 Pandemic
Authors: Molchanov N. N. , Jian-Fei Yang 
Published: February 2021

Aim. The presented study aims to determine the reaction of Chinese consumers to the use of e-commerce and neuromarketing tools during the coronavirus pandemic and to develop guidelines for e-commerce companies regarding the use of neuromarketing tools in the post-pandemic period.Tasks. The authors assess the awareness and attitude of respondents as consumers (individuals) regarding e-commerce tools in the People’s Republic of China (PRC); assess the attitude of respondents as consumers (individuals) to neuromarketing tools in e-commerce in the PRC during the pandemic; develop guidelines for improving the neuromarketing methodology in the PRC in the post-pandemic period.Methods. The authors test several hypotheses using statistical analysis. The hypotheses are tested in practice on the basis of a survey (using handouts and online questionnaires) of individuals. The attitude of Chinese citizens to the use of e-commerce tools is examined. The respondents are asked questions with one answer, multiple answers, and Likert scale questions. Data is processed using IBM SPSS Statistics 26 software and statistical methods, such as frequency analysis, contrast of means, and a number of others.Results. The opinion of Chinese consumers on the practice of using neurotechnologies in e-commerce is comprehensively assessed. The study analyzes the awareness of Chinese consumers regarding neurotechnologies and their own consumer behavior, showing their attitude to the use of neurotechnologies in e-commerce in the context of the pandemic.Conclusions. First, the COVID-19 pandemic has not significantly affected the overall income and spending of Chinese citizens. Only one-third of the Chinese population has increased their use of e-commerce platforms to make online purchases. Second, the pandemic has changed the consumption patterns of the Chinese population, making them more open to online shopping. Third, the average time of browsing products and making purchasing decisions on e-commerce platforms for Chinese residents did not change significantly during the pandemic. Fourth, while some Chinese consumers had a negative experience using e-commerce platforms during the pandemic, they used them more often than usual and will make more online purchases in the post-pandemic era. Fifth, when making online purchases, Chinese consumers always pay attention primarily to the quality and price of goods rather than other factors.
Audit rotation and audit fee determination policy on audit quality with lowballing audit practice as the intervening variable
Authors: Listya Anisa , Siregar Muhammad Ichsan 
Published: February 2021

Purpose: This study aimed to analyze the effect of audit rotation and audit fee policy toward audit quality with lowballing audit practice as the intervening variable.
Research methodology: The research method used was path analysis with a sample of twenty manufacturing companies in Indonesia Stock Exchange during 2015-2019.
Results: The research results prove that the audit rotation and audit fee policy significantly affect the audit quality through the lowballing audit.
Limitations: The research sample used manufacturing companies listed on the IDX, so the generalization of this study's results for non-manufacturing and non-listed companies must be made carefully.
Contribution: This research can provide benefits for Audit Firms, regulators (PPPK), and professional associations (IAPI) as an evaluation of the implementation of audit rotation policies, implementation of regulations for determining audit fees following IAPI's Regulation No. 2 of 2016 concerning Determination of Financial Report Audit Service Fees, as well as evaluation of the implementation of the audit quality indicator guidelines formulated by IAPI.
Keywords: Audit rotation, Policy of determining audit fee, Lowballing audit, Negative abnormal audit fee, Audit quality
A way to improve neuro regional analgesia: what adjuvant is the best? A narrative review.
Authors: Dmytriiev Dmytro , Nazarchuk Oleksandr , Dmytriiev Kostiantyn , Lysak Evgenii , Zaletska Olesya 
Published: February 2021

Introduction. The aim of this review was to systematize known facts about the effects of adjuvants to local anesthetics in order to determine adjuvant with the best effect among all others. More precisely the time of action onset, depth of the effect, duration of the block and some additional effects such as “marker of intravascular injection”, safety and toxicity profile, along with the adjuvant, which have all these properties in a sufficient degree.
Materials and methods. We searched for information in Medline, PubMed, Scopus, Embase. 105 articles were identified regarding the topic, published since 1989 to 2020. Data from 105 articles about adjuvants to local anesthetics was analyzed and synthesized in this article.
Results. Regional methods of analgesia are becoming a crucial part of anesthesiologists’ practice and the knowledge about adjuvants is developing alongside with it, so there are more and more studies devoted to it. All them try to find to find “ideal” adjuvant, that have all needed effects at sufficient degree, but we think that due to the different groups that adjuvants belong to some adjuvants are better than another.
Combination of adjuvants is not positive at all times.
Conclusion. A variety of adjuvants to local anesthetics are available now, but yet data about most of them remains controversial, so more studies are required to found out best adjuvants and their adverse effects