bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic Monitoring in Gujarat, India, during 2020 Coronavirus Lockdown and Lessons Learned
Authors: Kumar Santosh , Kumar R. Chaitanya , Roy Ketan Singha , Chopra Sumer 
Published: February 2021

Abstract
The Gujarat region, situated in the westernmost part of India, experienced a deadly intraplate 2001 Mw 7.6 Bhuj earthquake. In the aftermath of the disaster, the Institute of Seismological Research established the Gujarat (India) seismic network in 2006. The network is being operated in online and offline modes, whereas, seismicity monitoring is being done in near-real-time, using data received from the online seismic stations. The Coronavirus disease-19 lockdown provided an opportunity to assess the network reliability in a difficult and challenging scenario. The positive aspect of the lockdown is reflected in signal-to-noise ratio, which improved significantly at all the sites during the lockdown, with more prominent being at sites located on top of the Quaternary sediments due to the absence of high-frequency anthropogenic noise. A sharp fall in the seismic background noise is noticed at most of the stations during the lockdown period, with respect to the prelockdown period. We used the lockdown data to identify other natural sources of noise, besides anthropogenic. The lockdown helped in solving the enigma of seismicity in certain pockets, which turned out to be related to quarry blasts.
Prevalence and characteristics of polycystic ovarian syndrome in women attending in outpatient department of obstetrics and gynecology of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Authors: Fatema Kaniz , Das Tripti Rani , Kazal Rezaul Karim , Mahamood Sharmeen , Pervin Hasna Hena , Noor Farah , Chakma Bidisha 
Published: February 2021

Background: Polycystic ovary syndrome (PCOS) is a heterogenous, multifactorial, complex genetic disorder. Most commonly, it affects the females of reproductive age. This is one of the most widespread diseases across the world and if left untreated, may result in infertility and even uterine cancer. Methods: A cross sectional observation study of 100 PCOS patients was carried out from August 2018 to July 2019 in gynecology out-patient department of Bangabandhu Sheikh Mujib medical university, Dhaka. In this study clinical, biochemical and hormonal profile of these patients were analyzed and correlation was done between clinical features and biochemical and hormonal profile. Results: The prevalence of PCOS was 6.11% in the gynecology out-patient visits and 35.39% among infertile women. The mean age group of the patients was 24.3±5.16 SD. The mean BMI was 24.66±5.34 SD. The mean duration of infertility was 5.17 years. The prevalence of metabolic syndrome in our study was 15.0%. In this study menstrual irregularity was the most common complaint. Spearman’s correlation between various clinical and laboratory parameters showed positive correlation exists between BMI and testosterone (r=0.4824; p<0.0001).Conclusions: The study showed that most of our polycystic ovary syndrome subjects were present with oligomenorrhea. Hirsutism and central obesity were also common presentation. Obese women with PCOS had more severe ovulatory dysfunction and need more attention for their appropriate management.
Diet and Nutrition Recommendations during the COVID-19 Pandemic
Authors: Jain Surabhi 
Published: February 2021

Coronavirus disease of 2019 (COVID‐19) is caused by coronavirus 2 (SARS‐CoV‐2), has affected the lives of people worldwide. This document aims to provide guidance on managing asymptomatic, symptomatic mild to moderate illness home quarantine patient’s diet and Nutrition needs. Specially in this time of pandemic, optimum Diet and Nutrition care becomes extremely necessary to manage the illness effectively. Dietary intervention can definitely decrese the severity and disease load of the country. In this time, Healthy positive lifestyle modification is of utmost importance which includes the Healthy diet and Nutrition food habits, meeting nutrition requirements as per medical issues, incorporation of physical activity and relaxation techniques for mental and emotional health.This review summarizes, evidence based literature, nutritional guidelines to support recovery in COVID-19 patients. In this article, we have tried to work out the dietary recommendaions with all the macro and micronutrients for patients suffering from asymptomatic to symptomatic mild to moderate COVID-19 illness, advised home quarantine. A healthy diet containing a variety of macronutrients and micronutrients can provide a significant amount of minerals, vitamins, antioxidants, and bioactive compounds, which can help in better outcomes in COVID-19 positive patients.
Electocardiographic changes in acute cerebrovascular accidents-a tertiary centre experience in South India
Authors: Sebastian Sajith , Susan Roy Jenny 
Published: February 2021

Cerebrovascular accident plays an important role in the morbidity and mortality of adults posing serious medical, socio-economic and rehabilitation problems. Electrocardiographic abnormalities have been known to occur in the context of neurological disease. The current study is an observational study aimed at elucidating the relation between cerebrovascular accident and ECG. To determine the frequency of ECG changes in cerebrovascular accident and to determine the variations in ECG manifestations and mortality in different types of stroke. 100 patients of acute stroke were considered. ECG was recorded in these patients within 24 hours of admission. Follow up of admitted patients was done to know the prognosis. ECG abnormalities noted among cerebral ischemic patients were presence of T Wave inversion (34.48%) and ST segment depression (32.76%) followed by QTc Prolongation (29.31%) and presence of U waves (27.59%). In cases of haemorrhagic Stroke, T wave inversion (33.33%) and arrhythmias (33.33%) were followed by U waves (30.95%) and ST segment depression (23.81%). Mortality was higher in patients with ST-T changes in ischemic group (66.66%) and in patients with positive U waves (60%) in haemorrhagic group. Studying ECG changes will provide insight in prognosis and management of stroke patients and may alter their management in coming future. ECG changes occurred very commonly in acute stroke. The changes are thought to be independent of the nature of stroke. It was noted that ST and T inversion being common in ischemic while T inversions and arrhythmias common in haemorrhagic CVA. It was also noted that the mortality was higher in patients with abnormal ECG following an acute Cerebrovascular event.
Revisiting the Land Conversion of the Protected Forest for the Mining Industry in Tumpang Pitu, Banyuwangi
Authors: Triatmojo Dimas Bagus , Atikah Warah , Fadhilah Nurul Laili 
Published: February 2021

Indonesia is a country that has abundant natural resources, both renewable and non-renewable. The wealth of natural resources contained in the motherland can be utilized for the needs and welfare of the people of Indonesia under Article 33 paragraph (3) of the 1945 Constitution. One of the natural resources in Indonesia is forests. The government establishes a forest area as a protected forest area for a benefit that is expected by law. There is a violation of the use of protected forest areas for interests outside the forestry sector, namely the conversion of the function of protected forests used as mining land violations that are contrary to Article 38 Paragraph 4 of Law Number 41 of 1999. Mining business activities have negative impacts as well as positive impacts that arise. Mining will harm environmental conditions that can affect the social life of the community, reducing the environmental quality of the positive impact of the existence of mining business activities in an area will cause changes to the economic level, the legal basis for protecting the affected communities in the mining sector, as mandated by Article 28G Paragraph (1) and Article 28H Paragraph (1) of the 1945 Constitution.
Keywords: Transfer of Protection Forest Functions, Mining Impacts.
Comparing the Contract Between Islamic and Indonesian Laws
Authors: Puneri Atharyanshah 
Published: February 2021

In the common transaction, the contract plays a crucial element made between the parties with their consent. Its importance reflects that the contract realizes the parties' agreements and the contract binds the parties mentioned in the agreements. This study aims to review the contract law by analyzing the law of contract from two different laws, which are Islamic and Indonesian laws. This study finds some similarities and differences between Islamic and Indonesian laws when they come to governing contracts. Every contract in Islamic law must comply with sharia aspects, and the law derived from the Quran and Hadith. Meanwhile, based on Indonesian law, a contract can be deemed legal when it complies with the requirements stated in Article 1320 Indonesian Civil Code, and every Contract in Indonesian Law comes and is derived from the Indonesian Civil Code.
KEYWORDS: contract law, Islamic law, Indonesian law.
Solid Fuel Based on Waste of Low-Utilized Combustible Energy Resources
Authors: Khroustalev B. M. , Pekhota A. N. , Nguyen Nga Thuy , Vu Phap Minh 
Published: February 2021

The paper presents main trends in growth and generation of waste, depending on increase of world GDP and the population of the planet. The main directions in extending the concept of national strategies for sustainable development have been considered with due account of energy and resource conservation problems, as well as the need for the rational use of natural and secondary resources in all countries of the world community. The energy potential use of combustible waste that has not found technological application is considered by many countries as one of the priority areas in the field of unconventional energy. The paper describes the main directions in application of the technology for briquetting multicomponent compositions into solid fuel. The developed production technology makes it possible to process waste products by briquetting them with the addition of various binders, and on the example of a binder component in the form of viscous hydrocarbon-containing waste, the main technological features of obtaining solid multicomponent fuel are presented in the paper. The paper describes the equipment for electrohydraulic treatment, which operates as a part of the preparation line for briquetting of the applied oily waste and that allows to reduce the sulphur content in the waste used, and such approach in general permits to regulate the environmental characteristics of harmful substance emissions at the maximum acceptable level. Taking into account the application aspects of the technology for wet briquetting of materials, the paper reflects the main results of the obtained dependences of humidity on productivity according to the content of the binder component. The proposed algorithm for solving the problem makes it possible to rationally use of substandard combustible industrial waste to obtain a multicomponent solid fuel, while at the production stage, the energy and environmental aspects of the resulting fuel are taken into account with due consideration of the component composition of the fuel.
Methodological Tools for Evaluating Effectiveness of Capital Construction Projects of Oil Producing Enterprises
Authors: Chazov E. L. , Grakhov V. P. , Simchenko O. L. 
Published: February 2021

Due to the fact that most of the large oil fields in Russia, characterized by high production costs, are at the final stage of development; the issue of cost optimization has become increasingly important in recent years. The main cost items at oil and gas enterprises are design and construction (reconstruction) of oil field facilities. Analysis of currently used methods for ranking oil and gas projects has shown that all of them are inherently subjective, since they are based on expert opinion. The authors have developed a methodological tools for evaluating the effectiveness of capital construction projects of oil field facilities (for example, construction work on the site for inventory receiving bridges and lifting units), which allows to eliminate the influence of expert opinion as much as possible and, consequently, significantly improve the quality and validity of management decisions. The choice of the optimal project is based on a two – level assessment (stage 1– technical assessment, stage 2 – economic assessment). At each stage, an integral indicator is determined by calculation based on the results of objective data analysis and using the developed algorithms. Thus, it is possible to judge the effectiveness of any project without being based on a subjective approach in the assessment with the help of expert opinion.
Essential Cytoplasmic Role of the Histone Lysine Methyltransferase Setdb1 in Post-Transcriptional Regulation in Embryonic Stem Cells
Authors: Rapone Roberta , Maestro Laurence Del , Bouyioukos Costas , Albini Sonia , Cruz-Tapias Paola , Joliot Véronique , Cosson Bertrand , Ait-Si-Ali Slimane 
Published: February 2021

Abstract
Embryonic stem cells (ESCs) fate is regulated both at transcriptional and post-transcriptional levels. Indeed, several studies showed that, in addition to gene transcription, mRNA stability and protein synthesis are finely tuned and strongly control the ESCs pluripotency and fate changes. An increasing number of RNA-binding proteins (RBPs) involved in post-transcriptional and translational regulation of gene expression has been identified as regulators of ESC identity. The major lysine methyltransferase Setdb1 is essential for the self-renewal and viability of ESCs. Setdb1 was primarily known to methylate the lysine 9 of histone 3 (H3K9) in the nucleus, where it regulates chromatin functions. However, Setdb1 is also massively localized in the cytoplasm, including in mouse ESCs, where its role remains unknown. Here we show that the cytoplasmic Setdb1 (cSetdb1) is essential for the survival of mESCs. Functional assays further demonstrate that cSetdb1 regulates gene expression post-transcriptionally, affecting the abundance of mRNAs and the rate of newly synthetized proteins. A yeast-two-hybrid assay shows that cSetdb1 interacts with several regulators of mRNA stability and protein translation machinery, such as the ESCs-specific E3 ubiquitin ligase and mRNA silencer Trim71/Lin41. Finally, proteomic analyses reveal that cSetdb1 is required for the integrity of Trim71 complexes involved in mRNA metabolism and translation. Altogether, our data uncover the essential cytoplasmic function of a firstly supposed nuclear “histone” lysine methyltransferase, Setdb1, and provide new insights into the cytoplasmic/post-transcriptional regulation of gene expression mediated by a key epigenetic regulator.
Quantitative Analysis of Body Posture and Its Correlation With Cervical Posture in Various Malocclusions
Authors: Pradeep Shruthi , Venkatasubramanian Priyanka , Parameswaran Ratna , Vijayalakshmi Devaki 
Published: February 2021

Abstract
BACKGROUND: Considering that malocclusions can cause cervico-mandibular and cervico-cranial disorders, the aim of this study is to investigate whether there are significant differences in posture in subjects with skeletal class I, class II and skeletal class III malocclusion METHODS: A clinical study conducted on 90 subjects with Angle`s class I, II, III skeletal malocclusion. Standardized Casts of the subjects were used to analyze the tooth characteristics. Lateral cephalograms were used to assess cervical posture through cervical skull Rocabado analysis. A customized force platform with pressure sensors were used for posture analysis. RESULTS: There is a difference in body posture in subjects with skeletal class I, class II and class III malocclusion and a positive correlation between body posture and cervical posture is found in subjects with these classes of skeletal malocclusion. Subjects with class I malocclusion were found to have a normal cervical and body posture. Strain values from the force platform showed equal distribution of strain on both the feet. Subjects with class II malocclusion were found to have a forward cervical posture with the forward lean of body posture. Subjects with class III skeletal malocclusion were found to have a backward cervical posture with the posterior lean of body posture. CONCLUSION: The results suggest that different classes of malocclusion present with an alteration in cervical and body posture. Correction of the malocclusion or an intervention plan for the prevailing malocclusion should be done as early as possible which can be used to correct the posture thereby restoring the equilibrium of the body.
Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation
Authors: Wang Xinlong , Agrawal Vasundhara , Li Yue , Virk Ranya , Patel Priyam , Jain Surbhi , Rivera-Bolanos Nancy , Frederick Jane , Roth Eric , Bleher Reiner , Duan Chongwen , Bin Jiang , Ntziachristos Panagiotis , Backman Vadim , Ameer Guillermo 
Published: February 2021

Abstract
Efficient manipulation of cell fate is important for regenerative engineering applications. Lineage-specific differentiation of stem cells is particularly challenging due to their inherent plasticity. Engineered topographies may alter cellular plasticity through contact guidance. However, the ability to rationally design topographies to regulate phenotypic outcomes has been hindered in part by the lack of tools to quantify nanoscale chromatin structure reorganization in live cells. Herein we use micropillars, molecular, and nanostructural quantification tools to investigate how nuclear morphology in human mesenchymal stem cells (hMSCs) affects chromatin conformation and osteogenic differentiation. We show that micropillar-induced contact guidance is transduced via the cytoskeleton and impacts nuclear architecture, lamin A/C multimerization, histone modifications, and the 3-D conformation of chromatin within packing domains, a key regulator of transcriptional responsiveness. Micropillars repressed expression of genes associated with developmental processes and enhanced lineage-specific responsiveness, thereby decreasing cell plasticity and off-target differentiation, and facilitating osteogenic differentiation of hMSCs. Altogether, these findings reveal that chromatin reprogramming through contact guidance-induced nuclear deformation can be an efficient way to manipulate cell fate.
Binding of LncRNA-DACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility
Authors: Pan Zhenwei , Xue Gen-Long , Zhang Yang , Yang Jiming , Yang Ying , Zhang Ruixin , Li Desheng , Tian Tao , Zhang Xiaofang , Li Changzhu , Li Xingda , Yang Jiqin , Shen Kewei , Guo Yang , Liu Xuening , Yang Guohui , Lu Yanjie , Yang Baofeng 
Published: February 2021

Abstract

Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. The study aims to explore whether lncRNA-DACH1(lncDACH1) can regulate the distribution of Nav1.5 by binding to dystrophin and participate in ventricular arrhythmogenesis. LncDACH1 was confirmed to bind to dystrophin. Cardiomyocyte-specific transgenic overexpression of lncDACH1(lncDACH1-TG) reduced the membrane distribution of dystrophin and Nav1.5 in cardiomyocytes. The opposite data were collected from lncDACH1 cardiomyocyte conditional knockout (lncDACH1-CKO) mice. Moreover, increased ventricular arrhythmia susceptibility was observed in lncDACH1-TG mice in vivo and ex vivo. The conservative fragment of lncDACH1 inhibited membrane distribution of dystrophin and Nav1.5 and promoted the inducibility of ventricular arrhythmia. Upregulation of dystrophin in lncDACH1-TG mice rescued the impaired membrane distribution of dystrophin and Nav1.5. The human homologue of lncDACH1 inhibited the membrane distribution of Nav1.5 in human iPS-differentiated cardiomyocytes. Collectively, lncDACH1 regulates Nav1.5 membrane distribution by binding to dystrophin and participates in ventricular arrhythmogenesis.
Significance of nuclear quantum effects in hydrogen bonded molecular chains
Authors: Cahlik Ales , Hellerstedt Jack , Mendieta-Moreno Jesus , Švec Martin , Santhini Vijai , Pascual Simon , Soler-Polo Diego , Erlingsson Sigurdur , Vyborny Karel , Mutombo Pingo , Marsalek Ondrej , Siri Olivier , Jelinek Pavel 
Published: February 2021

Abstract
In hydrogen bonded systems, nuclear quantum effects such as zero-point motion and tunneling can significantly affect their material properties through underlying physical and chemical processes. Presently, direct observation of the influence of nuclear quantum effects on the strength of hydrogen bonds with resulting structural and electronic implications remains elusive, leaving opportunities for deeper understanding to harness their fascinating properties. We studied hydrogen-bonded one-dimensional quinonediimine molecular networks which may adopt two isomeric electronic configurations via proton transfer. Herein, we demonstrate that concerted proton transfer promotes a delocalization of π-electrons along the molecular chain, which enhances the cohesive energy between molecular units, increasing the mechanical stability of the chain and giving rise to new electronic in-gap states localized at the ends. These findings demonstrate the identification of a new class of isomeric hydrogen bonded molecular systems where nuclear quantum effects play a dominant role in establishing their chemical and physical properties. We anticipate that this work will open new research directions towards the control of mechanical and electronic properties of low-dimensional molecular materials via concerted proton tunneling.
Relationship Between Serum Hepatitis B Core-Related Antigen and Hepatitis B Surface Antigen in Hepatitis B Cirrhosis Patients With HBV-DNA Negative Status: A Cross-Sectional Study
Authors: Xu Bai-guo , Liu An-jing , Liu Ying , Han Tao , Guo Hua , Ding Xian , Xiang Hui-ling 
Published: February 2021

Abstract
Background: The relationship between serum hepatitis B surface antigen (HBsAg) and HBV core-related antigen (HBcrAg) titers, which is especially clinically important in monitoring virus replication activity and progression of liver disease, is not thoroughly studied in patients with hepatitis B cirrhosis, particularly in HBV-DNA negative patients. This retrospective study explored the relationship between serum HBcrAg and HBsAg titers in hepatitis B cirrhosis patients with HBV-DNA negative status. Methods: We analyzed data and samples from 180 patients diagnosed with HBV liver cirrhosis. Statistical analyses included baseline characteristics, univariate analysis, stratification analysis, three different analytical models, Spearman’s correlation analysis, generalized additive model, and two-piecewise linear regression model. Results: After adjusting for confounders (age, sex, primary hepatic carcinoma, HBeAg, Child–Pugh class, alcoholic liver disease, Diabetes mellitus , and type and duration of use of anti-HBV agents), a non-linear relationship was found between HBsAg and HBcrAg. The inflection point was 0.58. The effect sizes, confidence intervals, and P value on the left and right sides of the inflection point were 0.10, (–0.23–0.42), 0.555 and 0.62, (0.46–0.78), ＜0.0001, respectively. There was statistical significance (all p<0.01) between HBcrAg and HBsAg among all the stratification variables except for the "others" group in type of anti-HBV agents. Spearman’s correlation coefficient between HBsAg and HBcrAg was 0.613 (P<0.0001). Conclusions: There was a clear non-linear relationship between HBcrAg and HBsAg in patients with hepatitis B cirrhosis who were HBV-DNA negative, and the correlation between serum HBcrAg and HBsAg was moderate.