bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHARACTERISTIC OF AGE-DEPENDENT CHANGES IN PIAL ARTERIAL VESSELS ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
Authors: Горшкова О. П. 
Published: September 2021

Изучено изменение роли эндотелиальной гиперполяризации ( EDH ) в эндотелий-зависимой регуляции тонуса мозговых сосудов при старении в отсутствии и в условиях длительно текущей артериальной гипертензии (АГ). Исследовали роль EDH , индуцируемой активацией IK -каналов, и NO в дилатации пиальных артериальных сосудов на ацетилхолин у нормотензивных ( WKY ) и спонтанно гипертензивных крыс ( SHR ) в возрасте 4 и 18 мес. Установлено, что у крыс WKY механизм EDH преимущественно выражен в группе мелких сосудов. В процессе старения происходит снижение вклада EDH в осуществление дилатации мелких и средних сосудов с одновременным его повышением у артерий диаметром более 40 мкм. АГ приводит к повышению вклада процессов EDH в дилатацию сосудов мелкого и среднего диаметра. Старение, сопровождаемое длительно текущей АГ, снижает вклад EDH в дилатацию. У 18-месячных крыс SHR этот механизм выражен только в группе мелких сосудов диаметром менее 20 мкм. В основе возрастных изменений роли механизмов EDH в дилататорных ответах сосудов у крыс WKY и SHR лежит нарушение системы синтеза NO и изменение роли NO -опосредованных механизмов в эндотелийзависимой вазодилатации.
A comparative study of changes in the contribution of endothelium-dependent hyperpolarization (EDH) induced by activation of the intermediate-conductance calcium-activated potassium channels ( IK ) channels and the contribution of NO in pial arterial vessels dilation to acetylcholine (ACh) in normotensive ( WKY ) and spontaneously hypertensive ( SHR ) rats at the age of 4 and 18 months was conducted. It was found that in WKY , the EDH is mainly expressed in the group of small pial arterial vessels. During aging, the contribution of EDH to the dilatation of small (diameter less than 20 microns) and medium (20-40 microns) vessels decreases, while it increases in arteries with a diameter of more than 40 microns. Hypertension (HT) leads to an increase in the contribution of EDH processes to dilation of vessels of small and medium diameters. Aging, accompanied by long-term HT, reduces the contribution of EDH to dilation. In 18-month-old SHR, this mechanism is expressed only in a group of small vessels. Age-dependent changes in the EDH contribution in pial arterial vessels dilation in WKY and SHR rats are based on the NO synthesis system damage and a change in the NO -mediated contribution in endothelium-dependent vasodilation.
AGE AND NOSOLOGICAL STRUCTURE OF OPHTHALMOLOGICAL DISEASES OF PATIENTS OF THE OPHTHALMOLOGICAL CENTER OF SAINT-PETERSBURG IN 2015-2019
Authors: Сагинбаев У. Р. , Ахмедов Т. А. , Потемкин В. В. , Пушкин А. С. , Рукавишникова С. А. 
Published: September 2021

На нашей планете живeт около 1,3 млрд человек с такими нарушениями зрительного анализатора, как катаракта и глаукома, распространенность которых значимо выше у лиц пожилого возраста. Заболевания глаз остаются глобальной медикосоциальной и экономической проблемой, что связано как с прогрессированием болезни вплоть до слепоты, так и с отсутствием методов патогенетической терапии. Проведен ретроспективный анализ многолетней динамики и структуры случаев офтальмологических заболеваний у пациентов, проходивших лечение в многопрофильной больнице. Описана возрастная и нозологическая структура офтальмологических заболеваний. Выявлены закономерные особенности структуры заболеваний относительно разных возрастных групп, также обнаружены закономерности в их динамике.
About 1,3 billion people live on our planet with visual disorders such as cataract and glaucoma, the prevalence of which is signiﬁcantly higher in the elderlypopulation. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease to blindness and the lack of pathogenetic therapy methods. A retrospective analysis of the long-term dynamics and structure of cases of ophthalmological diseases of patients treated in a large multidisciplinary hospital was carried out. The age and nosological structure of eye diseases is described. Natural features of the structure of diseases relative to different age groups have been revealed, as well as patterns in dynamics have been found.
PREMATURE AGING IN METALLURGICAL INDUSTRY WORKERS DEPENDING ON THE BEHAVIORAL RISKS EXISTENCE
Authors: Мишина Е. А. , Беломестнова О. В. , Вараксин А. Н. 
Published: September 2021

Цель работы - определение роли поведенческих рисков в увеличении биологического возраста (БВ). На основе полученных данных для 499 работников по методике В. П. Войтенко была построена новая формула для расчета БВ. Установлено, что максимальные значения разности между БВ и должным биологическим возрастом (ДБВ) были у работников с самым низким уровнем физической активности (+0,54±0,3 года). Также в данной группе наблюдали максимальное количество жалоб на состояние здоровья. При увеличении ИМТ на 1 кг/м, разность БВ и ДБВ увеличивается в среднем на 0,16 года. Проведен двухфакторный дисперсионный анализ для выяснения совместного действия поведенческих рисков на величину БВ-ДБВ. При максимальном уровне курения и низкой физической активности отмечены самые высокие значения разницы между БВ и ДБВ.
The purpose of the study is to determine the role of behavioral risks in increasing biological age indicators. A new formula for calculating the biological age (BA) was plotted, based on the data obtained for 499 employees using the V. P. Voytenko’s method. It was found, that the maximum difference between biological and chronological (CA) ages are observed in workers with the lowest level of physical activity (0,54±0,3 years). In addition, there is a maximum number of health complaints in this group. With an increase in BMI by one kg/m, the difference between biological and chronological ages grow by 0,16 of the year. We conducted a two-factor analysis of variance in order to ﬁgure out the combined effect of behavioral risks on the BA-CA value. At the maximum level of smoking and the lowest level of physical activity, the highest difference values between BA and CA are observed.
THE EFFECT OF ANTIHYPERTENSIVE CHRONOTHERAPY ON INDICATORS OF THE DAILY BLOOD PRESSURE PROFILE IN ELDERLY PATIENTS WITH ARTERIAL HYPERTENSION WITH A HISTORY OF MYOCARDIAL INFARCTION
Authors: Агарков Н. М. , Прощаев К. И. , Лутай Ю. А. , Ильницкий А. Н. , Корнеева С. И. , Маркелова А. М. , Коломиец В. И. 
Published: September 2021

Традиционные схемы терапии больных артериальной гипертензией не всегда являются эффективными и нуждаются в совершенствовании на основе принципов хронобиологии. Цель работы - анализ влияния хронотерапии фиксированной комбинацией амлодипина, лизиноприла и розувастатина на показатели суточного мониторирования АД. У 62 больных 60-74 лет с инфарктом миокарда в анамнезе и артериальной гипертензией использована фиксированная комбинация амлодипина, лизиноприла и розувастатина в дозе 5/10/10 мг за 2 ч до достижения максимального САД (превентивная хронотерапия), 63 больных с аналогичными заболеваниями и возрастом этот препарат в дозе 5/10/10мг принимали вечером, а 58 человек - в утренние часы (традиционное лечение). Суточное мониторирование АД до и через 6 мес после лечения выполняли аппаратом «SpaceLabsMedical»(США) с расчетом общепринятых показателей. Установлена наибольшая эффективность превентивной хронотерапии по сравнению с другими вариантами лечения по достижению уровня целевого АД, снижению индексов времени и вариабельности САД, что позволяет рекомендовать данную фиксированную комбинацию в гериатрической практике.
Traditional treatment regimens for patients with hypertension are not always effective and need to be improved based on the principles of chronobiology. The purpose of this work is to analyze the effect of preventive chronotherapy with amlodipine, lisinopril, and rosuvastatin on daily blood pressure monitoring. In 62 patients with a history of myocardial infarction and hypertension at the age of 60-74, a ﬁxed combination of amlodipine, lisinopril and rosuvastatin at a dose of 5/10/10 mg 2 hours before reaching maximum systolic blood pressure (preventive chronotherapy), in 63 patients with similar diseases and age, this drug is taken at a dose of 5/10/10mg in the evening, and in 58 people - in the morning (traditional treatment). Daily monitoring of blood pressure before and 6 months after treatment was performed by the «SpacelabsMedical» device (USA) with the calculation of generally accepted indicators. The greatest effectiveness of preventive chronotherapy in comparison with other treatment options for achieving the target blood pressure level, reducing the time indices and the variability of systolic blood pressure has been established, which allows us to recommend this ﬁxed combination in geriatric practice.
Metagenomic characterization of planktonic communities during a mucilage event in the Çanakkale Strait (Dardanelles), Turkey
Authors: YILMAZ Sevdan , KÜÇÜKER Mehmet Ali , KAHRAMAN Dilek 
Published: September 2021

Bu çalışma da Çanakkale Boğazı'ında (Dardanel) müsilaj oluşumu sırasında planktonik toplulukların kompozisyonları metagenomik yaklaşımla araştırılmıştır. Müsilaj örnekleri, Çanakkale Boğazı'nın üç farklı istasyonunda (İstasyon 1: 40°15'22.53"K, 26°40'43.58"D; İstasyon 2: 40°10'59.21"K 26°37'81.17"D; İstasyon 3: 40°11'15.67"K, 26°39'90.81"D) yoğun müsilaj oluşumu gözlemlenen Mayıs 2021'de toplanmıştır. Filum düzeyinde toplam sekans sayısının 86.68% ini kapsayan baskın planktonik ökaryotlar, Dinoflagellata (%38.57), Protalveolata (%15.03), Diatomea (%12.41), Nematozoa (%8.44), Apicomplexa (%6.79) ve Chlorophyta (%5.43) olarak belirlenmiştir. En baskın OTU'ler (>%10), Alexandrium ve Syndiniales_Group_II olup, diğer baskın OTU'lar (>%2) ise Viscosia sp., Lankesteria, Arcocellulus, Thalassiosira ve Nannochloris olmuştur.
Bu çalışma, Türkiye'de meydana gelen bir müsilaj olayı sırasında Çanakkale Boğazı'nda planktonik toplulukların durumunu netleştirmiştir. Sonuç olarak, en baskın cinsin müsilaj üretme kabiliyeti olduğu bilinen Alexandrium olduğu belirlenmiştir. Bazı Alexandrium türleri toksin üretebilir, insan sağlığı üzerinde ciddi etkilere neden olabilir ve çift kabuklu, karides ve balık ölümlerine yol açabilir. Bu nedenle müsilaj yapısındaki Alexandrium toksinlerinin belirlenmesi için daha detaylı bir çalışmaya ihtiyaç vardır. Ayrıca elde edilen müsilajın ağır metal içeriği araştırılmıştır. Müsilajın yapısındaki As ve Cr konsantrasyonları atıklar için belirlenen düzenli depolama sahalarına bertaraf etme sınırlarının üzerindedir. Bu nedenle deniz yüzeyinden toplanan müsilajın düzenli depolama sahalarına gönderilmeden önce ağır metal içeriği kontrol edilmelidir.
الأفعال الكلامية الإنجازية في حوار فيلم "قيامة أرطغرل" الحلقة الأولى
Authors: Setiadi Syamsi , Kamal Muhammad , Rahmah Annisa Ayu 
Published: September 2021

This study aims to obtain a clear description of the form and function of illocutionary speech acts in the dialogue of the film "Qiyamatu Ertugrul" episode 1. The method used in this research is descriptive qualitative method. The research instrument is the researcher herself is assisted by a classification table which contains the types of illocutionary speech acts and their fusions. Thus the researcher got the results that illocutionary speech acts in the dialogue of the film "Qiyamatu Ertugrul" episode 1, are as follows: 19 assertive speech acts with a percentage of 21% consisting of a statement function of 16 utterances and 3 explanations of 3 speeches. Commissive speech acts were 8 utterances with a percentage of 8% consisting of the promise function of 6 utterances and threats of 2 utterances. The directive speech acts were 47 speeches with a percentage of 53% consisting of the function of forcing 1 speech, giving advice as much as 1 speech, forcing 2 speeches, praying for 2 speeches, asking for 3 speeches, offering as many as 3 speeches, begging as much as 5 utterances, and ordered as many as 30 speeches. Expressive speech acts were 15 utterances with a percentage of 17% consisting of praising 6 utterances, thanking 5 utterances and congratulating 4 utterances. There are also declarative speech acts that are not found in the dialogue of this film.
Model Pembelajaran Contextual Teaching and Learning (CTL) dalam Pembelajaran Bahasa Arab
Authors: Kurniati Depi , Nopiyanti Nopiyanti , Arifa Zakiyah 
Published: September 2021

This study intended to determine the feasibility of the Contextual Teaching Learning model in Arabic learning at MTsN Batu. This research-based on the stigma that developed in society showed that learning Arabic was considered problematic and complicated. That caused the problems that came from teachers were the lack of professionalism in teaching and the limitations of the components that will affect the Arabic learning process's implementation in terms of learning models. While the problems that arose from students in learning Arabic were the necessary experience, school background, mastery of mufradat (vocabulary), and family environmental factors, which then impact difficulties in understanding reading and not being able to master Arabic in full either in grammar and its communication. This research used quantitative and qualitative method with a descriptive-analytical type. The participants in this study were 32 students at MTsN Batu East Java. Research data collected from the questioner, observation, interviews and documentation. The study's findings showed that the percentage of the feasibility of the Contextual Teaching Learning (CTL) learning model in Arabic learning was 82.44% with mean 140,16. This finding means that the Contextual Teaching Learning (CTL) learning model's implementation at MTsN Batu was in an outstanding category. The components of the Contextual Teaching Learning (CTL) learning model during the learning process have been fulfilled. This study indicated that the Contextual Teaching Learning (CTL) model during the Arabic learning process was suitable only for specific materials.
Digital Literacy: Teachers' Perceptions of Using Google Accounts in the Online Learning Process
Authors: Fatmawati Fatmawati , Andriyani Noni , Ningsih Rika 
Published: September 2021

This current study explores the teacher's perspective on the usefulness of google account in the online learning process at SMAN 1 Tambang, Riau. The teachers and other school staff did not simply implement the policy of the distance learning process. The shift from face-to-face learning activities to online learning is confusing for teachers, especially senior teachers. Teachers are challenged to be able to use technology in carrying out their duties. The digital literacy of teachers is critical in the implementation of online learning. Hence, an understanding of google classroom, google meet, and google form is an influential media aid in the learning process, especially in online learning. The research method used is a survey method. The sample in this study was 46 teachers of SMAN 1 Tambang. The results showed that 46 respondents who filled out the research questionnaire, 75% stated Strongly Agree, 23% stated Agree, and 2% stated Disagree that google accounts were instrumental in the process of online learning during the Covid-19 pandemic. This result shows that the Google account is an effective learning media used in the online learning process during the Covid-19 pandemic. Therefore, teacher mastery in the use of Google accounts is part of digital literacy that needs improvement.
Problem-based Learning and Student Critical Thinking to Improve Learning Achievement at Private Universities in Aceh
Authors: Ibrahim Ibrahim , Akmal Nurul , Marwan Marwan 
Published: September 2021

This study aimed to determine the effectiveness of problem-based teaching and learning models to increase learning achievement and the relationship with students' critical thinking skills. This study used an experimental method with a design pretest-posttest control group. The population in this study were all semester four students of the Biology Education Department. Analysis of experimental data to measure the achievement of student learning outcomes with t-test and critical thinking skills using percentage description analysis, using statistical computer software programs. The research results show an increase in learning achievement, with an average N-gain for problem-based learning units is 70.9 (moderate) and 57.93 (moderate) for conventional classes. The t-test results show that the t-count value is 3.61 and the t-table is 1.991, so t-count t-table. The conclusion is that there are differences in learning outcomes in implementing problem-based teaching and learning models to increase learning outcomes with critical thinking skills of four at the Private University of Aceh Province, Indonesia.
ANALISIS SISTEM INFORMASI AKUNTANSI PERSEDIAAN BARANG DAGANG PADA CV. AIR MANDIRI BANJARMASIN
Authors: Imawati Yousida Imawati Yousida 
Published: September 2021

Abstrak: Penelitian ini bertujuan untuk menganalisis sistem informasi akuntansi persediaan barang dagang pada CV. Air Mandiri Banjarmasin. Metode yang digunakan dalam penelitian ini adalah penelitian deskriptif, yang berfokus pada sistem informasi akuntansi persediaan barang dagang pada CV. Air Mandri Banjarmasin yang seharusnya. Analisis data yang digunakan adalah membandingkan dengan teori sehingga akan diperoleh suatu gambaran terkait prosedur yang diterapkan selama ini. Hasil penelitian menunjukan bahwa terdapat sistem aplikasi khusus yang tidak dipergunakan secara efektif, sehingga sistem aplikasi tersebut tidak bisa dipergunakan untuk pelaporan persediaan barang dagang yang diharapkan dapat membantu tim gudang agar prosedur operasional persediaan barang dagang dapat dikelola dengan baik. Serta sistem pengendalian intern yang masih ada beberapa kelemahan pada saat pelaksanaan tugas pokok dan fungsi antar bagian banyak proses pekerjaan yang tidak ada dokumen rekamannya dan masih belum dapat memisahkan tanggung jawab fungsional secara tegas sehingga terjadi perangkapan tugas. Hal yang demikian akan memudahkan kemungkinan terjadinya penyimpangan atau kecurangan terutama kesalahan pencatatan persediaan barang dagang di gudang.

Kata Kunci : Sistem Informasi Akuntansi, Persediaan Barang Dagang, Sistem Pengendalian Intern.
ANALISIS SISTEM PENGENDALIAN INTERN PERSEDIAAN PADA KOPERASI TIRTA LESTARI BANJARBARU
Authors: Maria Anastasia  
Published: September 2021

Abstrak: Penelitian ini bertujuan untuk mengetahui sistem pengendalian intern terhadap persediaan pada Koperasi Tirta Lestari Banjarbaru selama ini dan juga memberikan masukkan sistem pengendalian intern terhadap Persediaan pada Koperasi Tirta Lestari yang seharusnya. Metode penelitian yang penulis gunakan dalam penelitian ini adalah metode kualitatif, sedangkan populasi penelitian ini adalah seluruh karyawan Koperasi Tirta Lestari yang berjumlah 17 orang dan sampel yang penulis tentukan berjumlah 4 orang dengan teknik purposive sampling. Jenis dan sumber data yang digunakan meliputi data kuantitatif dan data kualitatif serta sumber data primer dan data sekunder disamping itu, teknik pengumpulan data terdiri dari observasi, wawancara dan dokumentasi. Teknik analisis yang digunakan adalah data kualitatif dalam bentuk keterangan dan pembahasan teoritis yang bertujuan menganalisa hal-hal yang dapat dianalisa bukan dengan angka-angka tetapi dengan teori-teori yang dibuktikan dengan kenyataan yang terjadi. Hasil penelitian menunjukan pengendalian intern piutang harus memperhatikan beberapa hal, yaitu mengenai komponen dan unsur-unsur pengendalian yang terdiri dari 1. lingkungan pengendalian dengan melihat nilai-nilai etika, kebijakan dan praktek pegawai 2. Penentuan resiko

Aktivitas pengendalian harus lebih memperhatikan control dan pengawasan. 4. Informasi dan komunikasi harus disediakan 5. dan pemantauan lebih memperhatikan SOP yang dijalankan agar tidak dilanggar serta memperhatikan unsur-unsurnya.
Using Communicative Games to Improve Students’ Speaking Skill at SMPN 2 LAMASI
Authors: AD Fibri Indira Lisanty , DM Jumriani 
Published: September 2021

This research aims to determine the effectiveness of communicative games that can improve students’ speaking skills in class VIII at SMPN 2 Lamasi. The method that is applied in this research is a pre-experimental design. The population in this research is the seventh-grade students of SMPN 2 Lamasi, and the total sample is 15 students. The research uses a cluster random sampling technique in determining the sample. The instrument of this research is speaking. The results of this research indicated that after using the communicative games to improve students' speaking skills of SMPN 2 La masi increases. This shows that there are significant differences between student scores in pre-tests and post-test. The mean score of the students’ pre-test is 37.47 and 81.47 in the post-test. So, there is significant different between the result of pre-test and post-test after the treatment. Therefore, the researcher concludes that communicative games is effective in teaching speaking at eight grade of SMPN 2 Lamasi.
Evaluación de residuos de antibióticos en miel de abeja (Apis mellifera) en Guatemala
Authors: Torres Chic Numa Nidia 
Published: September 2021

OBJETIVO: en este estudio se dan a conocer los resultados para la detección de residuos de antibióticos en miel producida en Guatemala. La presencia de residuos de antibióticos en alimentos es un factor que puede afectar la salud humana, por esta razón las autoridades competentes en los países realizan muestreos nacionales, para prevenir que los alimentos presenten residuos de antibióticos. MÉTODO: se realizó una evaluación de las muestras tomadas de manera aleatoria durante la época de cosecha de miel de 2017 a 2020. Un total de 218 análisis para la detección de residuos de antibióticos en miel. Las muestras fueron analizadas mediante el método de análisis de Elisa o el método de cromatografía liquida masas-masas dependiendo del antibiótico a identificar. El plan de muestreo anual, realizado por el Ministerio de Agricultura, Ganadería y Alimentación, incluye a productores individuales y empresas que acopian miel para su comercialización nacional e internacional. RESULTADOS: dentro de los antibióticos analizados se encuentra el nitrofurano del cual se tuvieron resultados arriba del límite permitido (2,6 μg/kg) en el muestreo de 2017. CONCLUSIÓN: Esto confirma la importancia de continuar con los planes de muestreo para el control de los alimentos disponibles al consumidor.