bluuebunny/crossref_metadata_2025_split huggingface dataset:
FUNGSI KOMUNIKASI DALAM KELUARGA TERHADAP PERAN LAKI-LAKI DAN PEREMPUAN (Studi di Kompleks Patina Distrik Biak Kota Kabupaten Biak Numfor)
Authors: Hepi Hastuti  
Published: February 2021

Latar Belakang Komunikasi dalam kesejajaran yang harmonis antara pria dengan wanita adalah suatu kondisi hubungan kedudukan dan peran yang dinamis antara pria dengan wanita. Pria dan wanita mempunyai persamaan kedudukan, hak, kewajiban dan kesempatan, baik dalam kehidupan berkeluarga, bermasyarakat, berbangsa dan bernegara maupun dalam kegiatan pembangunan di segala bidang (Rahima, Swara, 2006). Tujuan penelitian untuk mengetahui Fungsi Komunikasi Dalam Keluarga Terhadap Peran Laki-Laki Dan Perempuan di Kompleks Patina Distrik Biak Kota Kabupaten Biak Numfor
Metode Penelitian. Jenis Penelitian ini menggunakan pendekatan penelitian kualitatif. Penelitian kualitatif merupakan jenis penelitian yang temuan-temuannya tidak diperoleh melalui prosedur statistik ataupun bentuk hitungan lain (Strauss, 2003:4). Metode penelitian kualitatif dapat digunakan untuk mengungkap dan memahami sesuatu dibalik fenomena, 20 orang.
Hasil penelitian. Jumlah responden yang mengatakan bahwa ada pembagian kerja yang jelas antara laka-laki dan perempuan sebanyak 17 responden (85 %), sedangkan jumlah responden yang mengatakan tidak ada pembagian kerja antara laki-laki dan perempuan sebanyak 3 responden (15 % ). Jumlah responden yang mengatakan ada pembagian kerja yang antara suku yang terbanyak adalah suku Jawa sebanyak 7 responden (41,18 %) sedangkan jumlah responden yang mengatakan tidak ada pembagian kerja yang antara suku yang terbanyak adalah suku makassar sebanyak 1 responden (33,33 % ).
Simpulan, Untuk mewujudkan kesetaraan gender pada berbagai level masyarakat perlu dilakukan komunikasi yang didasari komitmen kuat untuk mengangkat perempuan dari kemiskinan struktural mulai dari individu atau diri sendiri, masyarakat, Negara, dan dunia internasional. Nilai kesetaraan gender perlu didukung oleh semua pihak, termasuk dalam lingkungan keluarga.
ANALISIS TINGKAT KEPUASAN DAN KEPENTINGAN PENGGUNA LAYANAN KPPN BIAK PADA MASA PANDEMI COVID-19
Authors: Yunan Rahmanto  
Published: February 2021

Penelitian ini bertujuan untuk menganalisis tingkat kepuasan dan kepentingan satuan kerja terhadap layanan yang diberikan oleh KPPN Biak selama masa pandemi covid-19 dengan membandingkan tingkat kepuasan dan kepentingan satuan kerja terhadap layanan KPPN Biak tahun 2020 dan 2019. Selain itu adapun tujuan lainnya dalam penelitian ini adalah untuk mengetahui efektifitas upaya yang dilakukan KPPN Biak dalam menjaga tingkat kepuasan layanan yang diberikan kepada satuan kerja selama masa pandemi covid 19. Ketidakpastian akan berakhirnya pandemi covid 19 membuat KPPN Biak harus mengambil langkah-langkah strategis guna menjaga tingkat kepuasan satuan kerja. Adanya perubahan drastis sistem layanan dari tatap muka langsung menjadi sistem online bisa mempengaruhi kepuasan satuan kerja terhadap layanan KPPN Biak. Jenis penelitian ini adalah penelitian deskriptif kuantitatif. Penelitian ini menggunakan data primer diperoleh dari hasil kuesioner kepada responden. Jumlah responden yang dilakukan survei adalah sebanyak 19 satuan kerja dari total 51 satuan kerja yang ada di Kabupaten Baik dan Kabupaten Supiori. Hasil penelitian menunjukkan yakni : 1) Tingkat kepuasan dan kepentingan satuan kerja terhadap layanan yang diberikan oleh KPPN Biak selama masa pandemi covid 19 memperlihatkan peningkatan nilai indeks kepuasan satuan kerja semester I Tahun 2020 sebesar 0,01 dibandingkan dengan hasil yang diperoleh pada periode yang sama tahun 2019. 2) Berbagai upaya yang dilakukan oleh KPPN Biak untuk menjaga tingkat kepuasan satuan kerja selama masa pandemi covid 19 terbukti cukup efektif dalam menjaga kepuasan satuan kerja terhadap layanan KPPPN Biak dengan naiknya nilai rata-rata tingkat kepuasan satuan kerja semester I Tahun 2020 sebesar 1,67 dibandingkan dengan hasil tahun 2019.
O Estado como empresário do ouro: uma questão de soberania nacional e de relevante interesse coletivo
Authors: Souza Cláudio Luiz Gonçalves , Clark Giovani 
Published: February 2021

O Estado Brasileiro, na condição Empresário, pode exercer papel estratégico na condução e controle das atividades produitvas relacionadas à exploração e explotação mineral de ouro, na atual conjuntura "global", a fim de concretizar a soberania nacional e o desenvolvimento da nação. Por outro lado, a atividade de mineração revela-se, mormente no Brasil, ao longo de todos os anos de sua existência, desde a fase colonial até nos dias atuais, como sendo um dos principais produtos nacionais, ainda que na condição de commodity, responsável por resultados positivos em nossa balança comercial. A investigação do ensaio tem como objeto central a possibilidade constitucional do Estado intervir diretamente no domínio econômico, enquanto empresário, na mineração de ouro, por relevante interesse coletivo, visando utilizar o ouro como reserva cambial e meio de pagamento internacional pelo Estado. A pesquisa é bibliografia e documental, possuindo como referencial teórico os ensinamento intervenção estatal no domínio econômico do Prof. Washington Albino Peluso de Souza, bem como a distinção entre ação e intervenção estatal no domínio econômico do Prof. Eros Roberto Grau.
Elaboração de um material educativo para subsidiar a prática de professores de educação física no trabalho com alunos com perda auditiva
Authors: Romera Luciano Coelho , Delgado-Pinheiro Eliane Maria Carrit , Santos Flávia Rodrigues dos , Pinheiro Osni Lázaro 
Published: February 2021

No contexto educacional evidencia-se a necessidade de materiais educativos sobre a temática da perda auditiva que auxiliem professores de educação física em sua prática. O objetivo deste estudo foi elaborar e validar um material educativo para subsidiar a prática de professores de educação física nas atividades com alunos com perda auditiva. Foi construído um instrumento contendo assertivas sobre temas que poderiam ser abordados no material educativo. As assertivas foram acompanhadas por escala Likert. O item foi validado quando atingiu índice de concordância de 80%. Os temas foram avaliados por juízes especialistas, das áreas de Fonoaudiologia (n=4), Pedagogia (n=2) e Educação Física (n=2). Posteriormente foi elaborada uma versão preliminar do material validada pelos mesmos juízes e mais dois professores de educação física com experiência com alunos com perda auditiva. Nesta etapa a validação abordou aspectos do conteúdo, linguagem, ilustrações, layout, motivação e cultura, que deveriam atingir o índice de concordância de 80%. Dentre os dez temas propostos, nove foram considerados pertinentes. O item não validado referia-se ao uso de figuras com a Língua Brasileira de Sinais. Na segunda etapa do estudo, os únicos itens que não atingiram o índice de concordância mínimo referiam-se ao layout. As sugestões dos juízes relacionavam-se ao tamanho da letra e cores de fundo de algumas ilustrações. Foram realizadas as adequações sugeridas pelos juízes. O delineamento utilizado nesta pesquisa permitiu elaborar um material educativo validado com critérios metodológicos, contendo informações objetivas e ilustrações que poderão subsidiar professores de educação física na atuação com alunos com perda auditiva.
SISTEMÁTICA LEGAL Y EL BIEN JURÍDICO PROTEGIDO EN EL DELITO DE AMENAZAS
Authors: Posada Pérez José Antonio 
Published: February 2021

Este artículo analiza los diferentes delitos de amenazas contenidos en el Código Penal español. El objetivo de este documento es motivar la producción de estudios científicos sobre este particular tema teniendo en cuenta que no se ha presentado ningún resumen o actualización relevante de los aspectos más importantes de estos delitos durante casi una década. La investigación incluye una referencia al desarrollo histórico de las figuras más un estudio detenido de los delitos de amenazas en la legislación española en vigor. A la hora de interpretar el Código Penal actual, se tienen en cuenta todos los aspectos de cada delito para dilucidar la razón de la prohibición. Además, se hace referencia a la discusión sobre el bien jurídico protegido penalmente con un especial interés.
This article analyzes the several crimes of threat contained within the Spanish Criminal Code. The aim of this report is to motivate the production of scientific studies surrounding this particular issue; considering that a relevant resumé or actualization of the most important aspects of these crimes hasn’t been presented for almost a decade. The research includes a reference to the historical development of the offences plus a scanned study of the Spanish law in force regarding crimes of threat. When interpreting the current Criminal Code, every aspect of each crime is considered in order to elucidate the reason of the prohibition. Moreover, there is a special interest in arguing the object of criminal protection.
La fascinazione esotica nei colori della moda
Authors: Arcangeli Massimo 
Published: February 2021

The article provides, through a rich exemplification, an illustration of the cromonymic richness of the Italian language, with particular reference to some of the main realia involved in the colours naming: from animals to the natural environment, from plants to fruits, from cosmetics to textiles, from precious stones to the widest variety of objects. The attention is then focused, in particular, on the vocabulary of fashion (observed on a textual sample drawn from the magazine Vogue), that in Italian as well as in other languages documents an interesting general symptomatology of the perceptual spectrum and the colours psychosensory representation, for its tonality, brightness and purity, which involves innumerable nuances.
Composti italiani “di moda”
Authors: Catricala' Maria 
Published: February 2021

In this article a series of Italian Fashion Language compounds is analyzed at the light of the cognitive perspective and the semantic value. The count of the compounds (present in the journalistic corpus FLaSC1 and collected into the most known fashion dictionaries) is the first problematic point presented here, because the bounds of the class can change in a relevant way on the base of the definition of the term ‘compound’, the exclusion/inclusion of the foreign elements, the possible presence of hybrid units that cannot be defined words, but are used as word (e.g. pseudo-prefixes, it. prefissoidi). The second focus is the classification of the different kinds of compounds and a presentation of two subcategory (simultaneous vs. sequential), that is useful for explaining the semantic differences between similar models and formats. Third, but not least, we show that the conceptual map, emerging by the Italian compounds, profiles an idea of garments and accessories very complex and inter-culturally and inter-linguistically marked.
Sequentially Targeting Cancer‐Associated Fibroblast and Mitochondria Alleviates Tumor Hypoxia and Inhibits Cancer Metastasis by Preventing “Soil” Formation and “Seed” Dissemination
Authors: Yi Xiaoli , Yan Yue , Li Lian , Li Qiuyi , Xiang Yucheng , Huang Yuan 
Published: February 2021

AbstractTumor metastasis is facilitated by the formation of the premetastatic niche (PMN) in destination organs and the dissemination of cancer cells detached from a primary tumor. This study reports a sequential combination strategy that exerts a profound anti‐metastasis effect by inhibiting both PMN formation and cancer cell dissemination. The approach consists of (1) cancer‐associated fibroblast cells (CAFs)‐targeting liposome and (2) mitochondria‐targeting polymer. The liposome depletes CAFs and reduces tumor stroma, leading to a significant increase in intratumoral oxygen perfusion. The polymer disrupts mitochondria aerobic respiration in cancer cells, leading to a considerable decrease in intratumoral oxygen consumption. With the complementary mechanisms, their combination drastically alleviates the hypoxia in orthotopic breast tumor and inhibits the pulmonary PMN formation by downregulating various hypoxia‐induced PMN‐fostering factors. In addition, the CAFs depletion by the liposome abrogates the metastasis‐promoting crosstalk with cancer cells; meanwhile, mitochondria dysfunction by the polymer cuts off the energy supply that supports metastasis, together resulting in an efficient suppression of cancer cell dissemination. With the two‐pronged strategy targeting these two aspects, the primary tumor is prominently inhibited, and distant metastasis is completely eradicated. This study provides a generalizable approach of sequential CAFs depletion and mitochondria disruption to combat metastatic tumors.
Bioswitchable Antibacterial Coatings Enable Self‐Sterilization of Implantable Healthcare Dressings
Authors: Wang Anzhi , Duan Shun , Ding Xuejia , Zhao Nana , Hu Yang , Ding Xiaokang , Xu Fu‐Jian 
Published: February 2021

AbstractHealthcare‐acquired bacterial infections are a threat to public health. Therefore, development of self‐sterilizing implantable dressing materials is in increasing demand. Herein, a series of quaternized triblock copolymers, namely, QP‐b‐PCL‐b‐QPs, are synthesized and self‐assembled into reverse micelles (RMs) in tetrahydrofuran. The RMs contain biocompatible poly(ε‐caprolactone) (PCL) blocks in the shell to render biosafety and responsiveness, and biocidal quaternary blocks in the core to render antibacterial activity. In the presence of bacterial lipase, the biodegradable PCL blocks are hydrolyzed, resulting in the responsive release of quaternary biocidal agents (QBAs) to enable self‐sterilization. The RMs can be facilely impregnated into commercial gelatin sponge (GS) to fabricate RM2‐coated GS, which impose potent antibacterial activity in the presence of lipase. Compared to Gram‐negative P. aeruginosa, the Gram‐positive S. aureus and B. subtilis are more susceptible to QBAs released from RM2‐coated GS. The in vivo antibacterial assays and histological analyses further confirm the validity of RM2‐coated GS in reducing bacterial infection in mice model. These results, taken together, provide a promising strategy for the development of bioswitchable self‐sterilizing dressing materials to reduce healthcare‐acquired bacterial infections.
Transient increase in VEGF‐A leads to cardiac tube anomalies and increased risk of congenital heart malformations
Authors: Rykiel Graham , Gray MacKenzie , Rongish Brenda , Rugonyi Sandra 
Published: February 2021

AbstractVascular endothelial growth factor (VEGF) plays a critical role during early heart development. Clinical evidence shows that conditions associated with changes in VEGF signaling in utero are correlated with an increased risk of congenital heart defects (CHD) in newborns. However, how malformations develop after abnormal VEGF exposure is unknown. During embryogenesis, a primitive heart, consisting of an endocardial tube enveloped by a myocardial mantle, is the first organ to function. This tubular heart ultimately transforms into a four‐chambered heart. To determine how a transient increase in VEGF prior to heart tube formation affects heart development leading to CHD, we applied exogenous VEGF or a control (vehicle) solution to quail embryos in ovo at Hamburger‐Hamilton (HH) stage 8 (28–30 hr of incubation), right before heart tube formation. Light microscopy analysis of embryos re‐incubated after treatment for 13 hrs (to approximately HH11/HH12) showed that increased VEGF leads to impaired heart tube elongation accompanied by diameter expansion. Micro‐CT analysis of embryos re‐incubated for 9 days (to approximately HH38), when the heart is fully formed, showed that VEGF treatment increased the rate of cardiac malformations in surviving embryos. Despite no sex differences in survival, female embryos were more likely to develop cardiac malformations. Our results further suggest that heart tube malformations after a transient increase in VEGF right before heart tube formation may be reversible, leading to normal hearts.
Current strategies with sensing technologies to eliminate stress cardiomyopathy
Authors: Sun Hao , Ji Yongjian , Li Shuang , Dong Hongwei 
Published: February 2021

ABSTRACTStress cardiomyopathy refers weakening of heart muscle due to the continuous stress. Generally, the severe status of stress cardiomyopathy has been revealed after damaging the muscles and measured by the physical changes in the heart system. To overcome this issue, biosensor can be used, which could eliminate the late identification stress cardiomyopathy. With biosensors, different stress markers such as epinephrine, dopamine, catecholamine, α‐amylase, norepinephrine, serotonin and cortisol have been identified by a wide range of developments. These biosensors are available from laboratory to industry at the ranges of nano to macrodevices. To merge with the identification of stress cardiomyopathy, the above strategies might be utilized properly and can aid to reduce the stress‐related problems. This overview gleaned the currently available biosensing methods and the associated biomarkers at various stages of the developments and implementations of stress cardiomyopathy.
CCNI2 plays a promoting role in the progression of colorectal cancer
Authors: Lai Dong‐Ming , Bi Jiang‐Jiang , Chen Yong‐Hui , Wu Yu‐Di , Huang Qing‐Wen , Li Hai‐Jie , Zhang Sheng , Fu Zheng , Tong Yi‐Xin 
Published: February 2021

AbstractColorectal cancer (CRC) is one of the most common malignancies and most of the patients diagnosed with advanced CRC have unsatisfactory treatment effect and poor prognosis. The purpose of this study was to investigate the effect of CCNI2 on the development of CRC. In this sutdy, immunohistochemical staining was used to detect CCNI2 expression levels in clinical samples, meanwhile, the Kaplan‐Meier survival analysis was conducted. Celigo cell counting assay was used for screening shCCNI2s. QPCR and WB were performed to verify knockdown efficiency of CCNI2. Cell proliferation, colony formation, cell cycle, apoptosis, and mechanism investigation of CCNI2 knockdown were investigated by MTT assay, colony formation assay, fluorescence‐activated cell sorting, and human apoptosis antibody array, respectively. Otherwise, the mouse model of CCNI2 knockdown was also constructed. The results of immunohistochemical staining and qPCR indicated that CCNI2 had a high expression level in the CRC tissues and cell lines. Kaplan‐Meier survival analysis manifested that the high expression of CCNI2 suggested poor prognosis. The expression of CCNI2 was significantly reduced by CCNI2‐siRNAs, and the downregulated expression level of CCNI2 inhibited CRC cell proliferation and colony formation, arrested cell cycle in G2 phase, as well as promoted cell apoptosis. The various indexes of solid tumor in mice models indicated that CCNI2 knockdown could suppress the growth of CRC tumor. Based on the comprehensive analysis of the above results, CCNI2 was contributed to the progression of CRC and could serve as a prognostic marker for CRC.
Real world clinicopathologic observations of patients with metastatic solid tumors receiving immune checkpoint inhibitor therapy: Analysis from Kentucky Cancer Registry
Authors: Jacob Aasems , Wu Jianrong , Kolesar Jill , Durbin Eric , Mathew Aju , Arnold Susanne , Chauhan Aman 
Published: February 2021

AbstractThe state of Kentucky has the highest cancer incidence and mortality in the United States. High‐risk populations such as this are often underrepresented in clinical trials. The study aims to do a comprehensive analysis of molecular landscape of metastatic cancers among these patients with detailed evaluation of factors affecting response and outcomes to immune checkpoint inhibitor (ICI) therapy. We performed a retrospective analysis of metastatic solid tumor patients who received ICI and underwent molecular profiling at our institution.Sixty nine patients with metastatic solid tumors who received ICI were included in the study. Prevalence of smoking and secondhand tobacco exposure was 78.3% and 14.5%, respectively. TP53 (62.3%), CDKN1B/2A (40.5%), NOTCH and PIK3 (33.3%) were the most common alterations in tumors. 67.4% were PDL1 positive and 59.4% had intermediate‐high tumor mutational burden (TMB). Median TMB (12.6) was twofold to fourfold compared to clinical trials. The prevalence of mutations associated with smoking, homologous recombinant repair and PIK3/AKT/mTOR pathway mutations was higher compared to historic cohorts.PDL1 expression had no significant effect on radiologic response, but PFS improvement in patients with tumors expressing PDL1 trended toward statistical significance (median 18 vs. 40 weeks. HR = 1.43. 95%CI 0.93, 4.46). Median PFS was higher in the high‐TMB cohort compared to low‐intermediate TMB (median not reached vs. 26 weeks; HR = 0.37. 95%CI 0.13, 1.05). A statistically significant improvement in PFS was observed in the PIK3 mutated cohort (median 123 vs. 23 weeks. HR = 2.51. 95%CI 1.23, 5.14). This was independent of tumor mutational burden (TMB) status or PDL1 expression status. PIK3 mutants had a higher overall response rate than the wild type (69.6% vs. 43.5%, OR 0.34; p = 0.045). The results should prompt further evaluation of these potential biomarkers and more widespread real‐world data publications which might help determine biomarkers that could benefit specific populations.
Anti N‐Methyl‐D‐Aspartate (NMDA) receptor encephalitis: from psychosis to cognitive impairment
Authors: Vahabi Zahra , Etesam Farnaz , Zandifar Atefeh , Alizadeh Fatemeh , Badrfam Rahim 
Published: February 2021

AbstractIn this study, while presenting a clinical case with early psychiatric manifestations, we emphasized the need to pay attention to neurological diagnoses such as Anti N‐Methyl‐D‐Aspartate Receptor (NMDAR) encephalitis at the time of manifestation of these common symptoms.
Catalyst Deactivation by Carbon Deposition: The Remarkable Case of Nickel Confined by Atomic Layer Deposition
Authors: Afzal Shaik , Prakash Anuj , Littlewood Patrick , Choudhury Hanif , Khan Ghouri Zafar , Mansour Said , Wang Dingdi , Marks Tobin , Weitz Eric , Stair Peter , Elbashir Nimir 
Published: February 2021

AbstractIn hydrocarbon reforming processes, coke formation on the catalyst usually reduces reaction rates. We show that when subjected to thermal treatment, a commercial nickel catalyst, overcoated with alumina, ALD exhibited both higher activity per g Ni and higher carbon formation rates than an uncoated catalyst. During the temperature‐programmed reaction in a CH4+CO2 atmosphere, the uncoated catalyst deactivated rapidly from carbon buildup, but the overcoated catalyst displayed an increase in catalytic activity per g Ni, despite generating two times the surface carbon. The unexpected phenomenon was investigated via TEM/EDS, TGA/DSC, SEM, XRD and Raman spectroscopy. We hypothesize that this may be due to (a) formation of a thicker than expected ‘quasi‐ALD’ overcoat of amorphous alumina, (b) crystallization of ALD overcoat into nanofibers that act as secondary supports for migrating Ni, and (c) the ability of ALD overcoat to isolate carbon as carbon nano‐onions (CNOs).