bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYP24A1 Polymorphism Effect on Chronic Drugs Administration and Development of Osteomalacia: A Review Article
Authors: Alyaa Hussein Hammadi  , Shatha Hussein Ali  
Published: November 2021

Osteomalacia is a condition that causes bone thinning, which is frequently caused by a vitamin D deficiency. Vitamin D aids in the formation of the body's bones, therefore when levels are low, the bones are not as strong as they should be. Muscle weakness, bone discomfort, and a waddling stride are some of the symptoms of osteomalacia. The lower back hips, and legs are particularly vulnerable to pain. The weakening of the bones may make them more susceptible to fracture. Osetomalacia may be induced by a lack of sun exposure or a lack of vitamin D in the diet.
Bone metabolic problems, cancers, cardiovascular illnesses, and diabetes are all linked to a lack of 25OHD. Also linked to autoimmune illnesses and mental problems. Vitamin D is one of the most important minerals for human health.
Original Research: Expression Profile of CAPZA3 And TR-KIT Genes in Men with Globozoospermia & Asthenoteratospermia that Undergo ICSI Protocol
Authors: Dhuha. S. Namaa  , Miriam Jasim Shehab  , Rasha Sadeq Ameen  
Published: November 2021

Objective(s): Sperm-mediated oocyte activation depends upon suitable expression and assembly of sperm-borne oocyte-activating factors (SOAFs) during spermiogenesis. Several factors have been considered as candidates for oocyte activation in recent years. Globozoospermia is a severe sperm morphology disorder that is a rare type of teratozoospermia with an incidence of 0.1% among infertile individuals. testis-specific genes including CAPZA3 [capping protein (actin filament) muscle Z-line, alpha, which is considered as a nominee for sperm associated oocyte activating factors, an actin-capping protein, controlling actin polymerization during spermiogenesis. They contain a common bidirectional promoter. Another gene TR-KIT (a truncated form of the KIT receptor) which is a major sperm-associated oocyte-activating factor. The objective of this study was to investigate the expression profile of CAPZA3 and TR-KIT mRNA, in men with total globozoospermia, Asthenoteratospermia, and fertile individuals.
Materials and Methods: Semen samples were collected from three groups including 25 fertile men, 20 Asthenoteratospermia and 12 Globozoospermia that undergo intra-cytoplasmic sperm injection (ICSI), Expression of CAPZA3 and TR-KIT were assessed by Real time PCR.
Results: Individuals with Globozoospermia have presented significantly lower expression of CAPZA3 and TR-KIT mRNA when compared with fertile men. Asthenoteratospermia (male factor) showed significantly lower expression of CAPZA3 mRNA, whereas non-significantly of TR-KIT mRNA. Levels of CAPZA3 and TR-KIT mRNA in the spermatozoa of fertile men were significantly higher than the corresponding values of the globozoospermic and Asthenoteratospermia subjects.
Conclusion: Analysis mRNA of CAPZA3 gene maybe assist the researcher to identify individuals with a lack of ability to induce oocyte activation and make them a candidate for artificial oocyte activation and help researcher to identify genetic defects associated with failed fertilization. whereas, mRNA of TR-KIT gene appears inability to induce oocyte activation
Uji Presisi dari Nonholonomic Mobile Robot pada Rancang Bangun Sistem Navigasi
Authors: Patriawan Desmas A. , Natakusuma Bagoes P. , Arifin Ahmad Anas , Maulana Hasan S. , Irawan Hery , Setyono Bambang 
Published: November 2021

Navigasi menjadi bagian yang penting bagi kendaraan. Global positioning system (GPS) merupakan sistem navigasi yang paling banyak digunakan pada kendaraan. Namun dengan akurasi 5-10 meter membuat GPS tidak bisa diaplikasikan dalam bagian sistem kendali pada kendaraan. Penambahan sensor inertia measurement unit (IMU) diharapkan mampu menambahkan akurasi pada Gerakan kendaraan. Kendaran yang digunakan adalah robot beroda dengan sistem nonholonomic. Pada robot ini dipasang Sensor IMU, GPS dan kontroler supaya robot tersebut bisa berputar lalu melaju secara lurus dengan kordinat yang sudah ditentukan. Hasil pengujian didapatkan robot memiliki respon time sebesar 4.1 detik tanpa kontroler dan 2.1 detik dengan kontroler. Akurasi sudut dari 5 menjadi 2 .
PENGEMBANGAN MODUL IPA BERBASIS DISCOVERY LEARNING DALAM MENINGKATKAN, KETRAMPILAN PROSES, PESERTA DIDIK PADA MATERI GETARAN, GELOMBANG, DAN BUNYI
Authors: RAHAYU PUJI , RUMAHORBO BASA T , WAHYUDI IRFAN 
Published: November 2021

This research is a research and development that aims to know to create an integrated IPA module, the feasibility of integrated IPA module, the improvement of the activity, science process skill, and student’s learning result by using integrated IPA module, the advantage and disadvantages using integrated IPA module based on discovery learning on vibration, waves, and sounds materials. The research method is research and development. This research conducted in class VIII C of SMP YPK 2 Manokwari with 30 students. The result shows that : 1) The feasibility of integrated IPA module based on discovery learning on vibration, waves, and sounds materials from validator 91,49% with very decent category, IPA teachers got 90,83% with very good category, and the result of try out in small scale got 87,75% 2) The integrated IPA module based on discovery learning on vibration, waves, and sounds can improved the science process skills with skilled categories (63,15%) 3)
PEMANFAATAN LIMBAH SABUT KELAPA MENJADI POT BUNGA UNTUK MENUNJANG PEREKONOMIAN WARGA DESA PENGALIHAN DIERA PANDEMI COVID’19
Authors: Eliah Siregar  
Published: November 2021

Penghasil utama masyarakat Desa Pengalihan adalah dari perkebunan kelapa, yang dihasilkan masyarakat dari perkebunan kelapa hanyalah kelapa bulatan, kopra putih dan arang tempurung namun saat ini nilai jual harga kelapa sedikit menurun sehingga berpengaruh pada pendapatan masyarakat. Pemanfaatan hasil samping tanaman kelapa sangat besar peluangnya salah satunya adalah dari sabut kelapa. Pemanfaatan limbah sabut kelapa sangatlah efektif dan dapat menjadi salah satu pilihan alternatif untuk menunjang perekonomian masyarakat Desa Pengalihan Diera Pandemi Covid’19. Limbah Sabut kelapa adalah salah satu biomassa yang mudah didapatkan dan merupakan hasil samping pertanian. Limbah sabut kelapa sangat berpotensi sebagai Pot Bunga karena mengandung selulosa yang di dalam struktur molekulnya mengandung gugus karboksil serta lignin yang mengandung asam phenolat yang dibutuhkan bagi tanaman.
The new winter bread wheat variety of universal type ‘Donskaya Step’
Authors: Skripka O. V. , Samofalov A. P. , Podgorny S. V. , Gromova S. N. , Chernova V. L. , Kravchenko N. S. 
Published: November 2021

Introduction and methodology. Wheat bread belongs to the greatest inventions of the mankind. Therefore, the study aimed at solving the issues of improving its productivity and quality, stabilizing the gross yield of wheat grain have always arisen a great interest of researchers and specialists in agricultural production. The most accessible source of improving yields and gross harvests is a variety.The purpose of the current study was to characterize the winter bread wheat variety ‘Donskaya Step’ according to the main economically valuable traits and properties. The study was carried out by the FSBSI “ARC “Donskoy”” from 2016 to 2020 on the experimental plots of crop rotation belonging to the winter wheat department. The object of the study was the winter bread wheat variety ‘Donskaya Step’. The variety ‘Ermak’ was used as a standard variety. There were used four forecrops: maize for grain, peas, sunflower and green fallow. The trials were conducted in sixfold replications. The accounting area of the plot was 10 m2.Results. The variety was sent to the State Variety Testing in 2016. In 2020 it was introduced into the State List for the North Caucasus and Low Volga regions of the Russian Federation. This variety has a high potential for grain productivity. The maximum yield of 11.83 t/ha was obtained in 2017 when sown in weedfree fallow. The average yield through four years of the competitive variety testing (2016–2020) was 9.77 t/ha, which is on 0.96 t/ha higher than that of the standard variety ‘Ermak’. The variety ‘Donskaya Step’ is a middle-maturing variety that forms ears and ripens as the standard variety ‘Ermak’. The variety forms high and stable yields due to increased frost resistance, drought resistance and resistance to the main wheat leaf diseases.
Evolución de la Cirugía de Epifisiodesis
Authors: Sepúlveda O. Matías , Ferrada A. Paulina , Miranda-Chacón Zaray , Saban G. Esteban , Pérez G. Juan 
Published: November 2021

La modulación quirúrgica del crecimiento fisiario, más conocida actualmente como “Crecimiento Guiado”, es un procedimiento utilizado como tratamiento para las diferencias de longitud o alteraciones de ejes de las extremidades. Si bien su uso se considera en aumento por el desarrollo de nuevas técnicas menos invasivas, no existen análisis estadísticos en la literatura que comprueben dicha afirmación.Objetivo: Evaluar la incidencia de la cirugía codificada como “Epifisiodesis (Fémur y/o Tibia)” en la población chilena desde el 1 de enero del 2010 al 31 de diciembre del 2019, los días de estadía hospitalaria relacionada con dicho código, y los datos demográficos de la población estudiada.Pacientes y Método: Se obtuvo desde la base de datos del Departamento de Estadísticas e Información de Salud (DEIS) de Chile, todos los egresos hospitalarios desde el 1 de enero del 2010 al 31 de diciembre del 2019, desde donde se extrajeron los resultados con el código de “Epifisiodesis (Fémur y/o Tibia)”, en menores de 15 años. Se analizó el número de procedimientos por año, número de días de estadía hospitalaria, edad y sexo de los pacientes.Resultados: El número de procedimientos codificados como “Epifisiodesis (Fémur y/o Tibia)” fue en aumento en Chile, durante el período analizado. Los días de estadía hospitalaria asociados a dicho procedimiento disminuyeron de forma progresiva entre los años 2012 y 2017. El procedimiento se realizó principalmente en mujeres, y en el grupo de 5-9 años, mostrando una tendencia al alza en niños del grupo de 10-14 años entre los años 2015 y 2019.Conclusiones: Se debe realizar mayores análisis para determinar los factores que producen estos resultados, los que probablemente se relacionen a acceso a técnicas más eficaces y sencillas, con menor morbilidad.
Revista Chilena de Pediatría/Andes Pediatrica en el nuevo milenio. Análisis bibliométrico.
Authors: Schonhaut B. Luisa , Oppenheimer S. Ilan , Del Río G. Catalina , Pizarro F. Vicente , Costa-Roldan Italo , Harris Paul R. , Cano Sch. Francisco 
Published: November 2021

Andes Pediatrica/Revista Chilena de Pediatría (AP/RCHP), mantiene un perfil de documentos que abarca todos los formatos de la publicación científica, desde Artículos Originales (AO) hasta Cartas al Editor. Para una adecuada planificación editorial se requiere un análisis bibliométrico de largo plazo. Objetivo: Describir el perfil de AO publicados en AP/RCHP en las últimas 2 décadas. Metodología: Desde una lista de vocabulario controlado se estandarizaron los descriptores temáticos y metodológicos de los documentos del 2000 al 2020. Se analizó nacionalidad, género y profesión de los autores, tipología documental y diseño de los AO. Se analizó los descriptores citados en Google Schoolar y los más visitados en el sitio web de la revista en los últimos años. Resultados: Se publicaron 1.738 manuscritos, 580 (33,4%) AO, con un incremento de 59 a 129 AO entre el primer y último trienio. El promedio de autores fue superior para los AO (4,7) que para los no originales (3,0); el año 2020 hubo 9 colaboraciones multicéntricas de distintos países. Los AO de autores extranjeros incrementaron de 3,3 a 28,7%, la autoría en primera posición de profesionales no médicos aumentó de 15 a 31%, hubo predominio de primer autor femenino (relación 1,4/1). De los AO 9,1% eran experimentales, 3,3% cualitativos y el resto cuantitativos observacionales. Los descriptores más publicados fueron Nutrición, Infectología, Neonatología y Broncopulmonar, mientras que los más citados fueron Nutrición, Neonatología y Salud Oral, sin tendencia entre los más visitados. El 44% de los artículos más citados y el 35% de los más visitados fueron AO. Conclusiones: Destaca un importante incremento de AO publicados, con baja frecuencia de diseños experimentales. Hubo participación de autores de distintas nacionalidades y profesiones. Los AO contribuyeron a un tercio de las visitas y casi la mitad de las citas, sin demostrarse correlación entre los descriptores más publicados y los más citados.
Evaluación docente escuela de enfermería
Authors: Salgado Jiménez Ruth Elizabeth , Tobar Lozada Wilson Casimiro , Fuertes López Anyela Jackeline 
Published: November 2021

La presente investigación analiza dos períodos académicos: septiembre 2012 /febrero 2013 y marzo / agosto 2013. Tornando en cuenta los resultados de la evaluación docente integral que consta de cuatro componentes: La Hetero-evaluación (alumnos); la autoevaluación; la evaluación del directivo y la evaluación del par académico.La ponderación de cada componente y el cálculo del pontaje total se muestran de acuerdo al modelo matemático T = 0.25 (A) + 0.40 (EED) + 0.20 (EPP) + 0.15 (EDD). La evaluación docente es un proceso que se realiza en un lapso según consta en el calendario académico, utilizando el software QUANTO, el cual puede ser utilizado vía internet dentro o fuera del campus universitario.La evaluación se la realiza a todos los docentes tanto de teoría como de práctica, la población investigada es en un 83.4% femenino y 16.6 % masculino para el primer período y para el segundo período un porcentaje de 85.72% femenino y un 14.28 % masculino.
Sosialisasi Protokol Kesehatan 3M pada Siswa SMP Negeri 26 Malang untuk Menghadapi Era Kenormalan Baru Pasca Pandemi COVID-19
Authors: Arvianti Eri Yusnita , Anggrasari Herdiana , Hastutiningtas Wahidyanti Rahayu 
Published: November 2021

The current condition, even though Covid-19 still exists, it has entered a new era of normality. So far, the education sector has implemented online learning, which has begun to take place face-to-face again but still follows health rules and protocols. The health protocol is implemented to protect all components in schools from the risk of Covid-19 transmission. SMP Negeri 26 Malang has also started to hold face-to-face learning activities. The learning activity began on April 19, 2021, which was carried out in stages. Therefore, SMP Negeri 26 need socialization related to health protocols as long as they carry out face-to-face learning activities. This socialization aims to provide information to SMP Negeri 26 Malang students regarding the prevention of covid-19 by implementing the health protocol, namely 3M (keeping a distance, wearing masks, and washing hands) to avoid covid-19 transmission. The results of this socialization are that students and students of SMP Negeri 26 Malang have understood the ways of transmission and prevention of Covid-19 using the 3M health protocol.ABSTRAKKondisi saat ini meskipun covid-19 masih ada, namun sudah memasuki era kenormalan baru. Selama ini bidang pendidikan menerapkan pembelajaran daring, mulai berlangsung lagi secara tatap muka, namun tetap mengikuti aturan dan protokol kesehatan. Protokol kesehatan diterapkan bertujuan untuk melindungi seluruh komponen yang ada di sekolah dari resiko penularan Covid-19. SMP Negeri 26 Malang juga mulai menggelar kegiatan belajar secara tatap muka. Kegiatan belajar tersebut dimulai tanggal 19 April 2021 yang dilakukan secara bertahap. Oleh karena itu siswa-siswa SMP Negeri 26 membutuhkan sosialisasi terkait dengan protokol kesehatan selama mereka melakukan kegiatan pembelajaran tatap muka. Sosialisasi ini bertujuan untuk memberikan informasi kepada siswa-siswi SMP Negeri 26 Malang terkait pencegahan covid-19 dengan menerapkan protokol kesehatan yaitu 3M (menjaga jarak, memakai masker, dan mencuci tangan) agar terhidar dari penularan covid-19. Hasil dari sosialisasi ini yaitu mayoritas siswa dan siswi SMP Negeri 26 Malang telah memahami terkait dengan cara penularan dan pencegahan covid-19 menggunakan protokol kesehatan 3M.
Chromomycosis: literature review and clinical case
Authors: Yakovlev A. B. 
Published: November 2021

A clinical case of leg skin chromomycosis is described, a review of the literature is given, the main modern medical methods, as well as methods of historical significance are briefly described. The individual links of the pathogenesis of chromomycosis (CM) are described, a list of nosologies to which chromomycosis should be differentiated is presented.Materials and methods. A clinical case of chromomycosis in a 63-year-old patient is presented. The process developed as a result of systematic frequent injury of the shins with sharp parts of plants.Results. The diagnosis of chromomycosis was established on the basis of anamnesis, clinic data, detection of the pathogen in the biopsy material.Conclusions. Thus, CM is a serious deep skin mycosis, which still causes an epidemiologically significant morbidity in workers of agricultural and related fields! It is difficult to treat it, especially in more severe clinical forms. Treatment usually consists of long periods of treatment with antifungal drugs, often associated with physical procedures and immunotherapy. This publication is intended to extract HMM from the list of ′forgotten diseases′ at least for a short time!
Efficacy of interleukin 17 inhibitor therapy in overweight and obese psoriasis patients (preliminary data)
Authors: Vladimirova I. S. , Smirnova I. O. , Obrezan A. G. , Zhelonkin A. R. , Yantsevich N. K. 
Published: November 2021

In recent years, comorbidity in psoriasis has been actively studied, one of the most significant of which is obesity. Obesity is a risk factor for dermatosis in susceptible individuals, which can affect the effectiveness of therapy for the disease, including genetically engineered biological drugs.The aim of the study. To study the effectiveness of therapy with an interleukin‑17 inhibitor (iskekizumab) and the dynamics of lipid parameters in patients with psoriasis and overweight and obesity.Material and methods. A retrospective study of 25 patients diagnosed with psoriasis vulgaris was carried out. Inclusion criteria were PASI more than 12 points, BSA more than 10% and sPGA more than 3 points, age over 18 years. Anthropomeric parameters and lipid profile data were studied. All patients received iksekizumab treatment according to the standard regimen. Evaluation of the effectiveness of therapy was carried out according to the dynamics of PASI indicators, as well as the frequency of patients achieving the response PASI 75, PASI 90 and PASI 100.Results. Obesity and overweight were diagnosed in 13 patients who made up the main observation group. The comparison group included 12 nonobese patients. Patients in the observation groups did not differ in sex and severity of psoriasis. In patients of the main group, hypertriglyceridemia was significantly more often diagnosed (55.6%; 95% CI: 33.7–75.4; in its absence in the comparison group; p = 0.0200), as well as other comorbidity – hypertension and metabolic syndrome (p = 0.0016 and p = 0.0052, respectively). On the background of therapy, skin rashes were resolved in patients of both observation groups. By the seventh week of therapy, there was a significant decrease in PASI, sPGA and BSA, by the 36th week, the rash was completely resolved in all patients (p < 0.001). There were no significant differences between the groups in the dynamics of clinical indicators of the severity of the disease. Body mass index did not change statistically significantly over the observation period in patients of both groups (p = 0.6690). Changes in lipid profile for all parameters were statistically insignificant. There were no significant differences in the frequency of achieving PASI of 75, 90 and 100% between the groups.
Antipruritic therapy issues on background of skin xerosis
Authors: Kruglova L. S. , Tipaeva E. V. 
Published: November 2021

The relationship of xerosis with various skin diseases is very multifaceted, at the same time, xerosis can be the cause of the onset or aggravation of itching. Modern recommendations for the external treatment of chronic dermatoses, accompanied by xerosis and itching, imply two directions: direct therapeutic measures during an exacerbation and the use of dermatocosmetics adapted to certain symptoms.Material and methods. We observed 26 patients (mean age 38.7 ± 1.9 years with atopic dermatitis, eczema, psoriasis or pruritus, where xerosis was present in the clinical picture and pruritus was noted. All patients used topical drugs in accordance with the nosology, in as an adjuvant therapy – Neotanin Comfort Plus cream.Research results. In atopic dermatitis, the corneometry index increased by an average of 21%, with eczema – by 20%, with psoriasis – by 22%, with skin itching – by 12%. Transepidermal water loss decreased in atopic dermatitis by 19.8%, with eczema – by 22.8%, with psoriasis – by 21.8%, with pruritus – by 18.4% The value of the total BRS index decreased by more than two times.Conclusion. The use of Neotanin Comfort Plus cream in combination with topical drug therapy (GCS, multicomponent drugs) is highly effective and safe in patients with atopic dermatitis, eczema, psoriasis or pruritus, which makes it possible to recommend it for use in wide clinical practice.
Experience of using photodynamic therapy for treatment of genitourinary syndrome of menopause
Authors: Surkichin S. I. , Avin M. , Mayorov R. Yu. 
Published: November 2021

This study reports about efficacy and safety of photodynamic therapy in Genitourinary Syndrome of Menopause (GSM).Material and methods. The study group included 12 patients with a diagnosis of urogenital syndrome of menopause. The trismeglumine salt of chlorin E6 in the form of a 1% gel was used as a photosensitizer. LED phototherapy apparatus Garmonia (photodynamic therapy apparatus (emitter 660 nm) was used as a radiation source. The PDT procedure was performed once every 7 days. The following scales were used to assess the effectiveness: Vaginal Health Index, Visual Analogue Scale, Dermatology Life Quality Index score, and general satisfaction with the course of procedures was also assessed.Results. The patients noted a significant regression of itching, burning, pain and dyspareunia after the course of photodynamic therapy. There was a decrease in dryness, on average, up to 3 points upon completing the course of procedures. Itching completely regressed in 6 out of patients. Dyspareunia significantly decreased in 4 patients and completely disappeared in 2 patients. The greatest effect according to the results of assessing the index of vaginal health was noted in relation to Ph-metry, as well as in relation to elasticity (4.17 points) and moisture (4.33 points). The median satisfaction score with treatment outcomes was 2.7 at last follow-up. There were no serious side effects during the entire period of treatment and after it.Conclusions. The following study reports that the photosensitizer with trismeglumine salt of chlorin E6 and PDT with a wavelength of 660 nm with an exposure for 30 minutes, an energy of 100 J/cm2, a power of 100 mV/cm2 , once every 7 days, is an effective and harmless method of treating GSM.