bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biophysical mechanism of the interaction between default mode network and working memory network
Authors: Yuan Yue , Pan Xiaochuan , Wang Rubin 
Published: April 2021

AbstractDefault mode network (DMN) is a functional brain network with a unique neural activity pattern that shows high activity in resting states but low activity in task states. This unique pattern has been proved to relate with higher cognitions such as learning, memory and decision-making. But neural mechanisms of interactions between the default network and the task-related network are still poorly understood. In this paper, a theoretical model of coupling the DMN and working memory network (WMN) is proposed. The WMN and DMN both consist of excitatory and inhibitory neurons connected by AMPA, NMDA, GABA synapses, and are coupled with each other only by excitatory synapses. This model is implemented to demonstrate dynamical processes in a working memory task containing encoding, maintenance and retrieval phases. Simulated results have shown that: (1) AMPA channels could produce significant synchronous oscillations in population neurons, which is beneficial to change oscillation patterns in the WMN and DMN. (2) Different NMDA conductance between the networks could generate multiple neural activity modes in the whole network, which may be an important mechanism to switch states of the networks between three different phases of working memory. (3) The number of sequentially memorized stimuli was related to the energy consumption determined by the network's internal parameters, and the DMN contributed to a more stable working memory process. (4) Finally, this model demonstrated that, in three phases of working memory, different memory phases corresponded to different functional connections between the DMN and WMN. Coupling strengths that measured these functional connections differed in terms of phase synchronization. Phase synchronization characteristics of the contained energy were consistent with the observations of negative and positive correlations between the WMN and DMN reported in referenced fMRI experiments. The results suggested that the coupled interaction between the WMN and DMN played important roles in working memory.
High-Performance Polyamide/Carbon Fiber Composites for Fused Filament Fabrication: Mechanical and Functional Performances
Authors: Dul Sithiprumnea , Fambri Luca , Pegoretti Alessandro 
Published: April 2021

AbstractThis study is focused on the 3D printing by fused filament fabrication (FFF) process of short carbon-fiber-reinforced polyamide (PA) composites. In particular, the effect of short carbon fiber (CF) on the mechanical, electrical and piezoresistivity properties of 3D-printed polyamide (PA) composite parts has been analyzed. In comparison with neat PA, the results revealed that the carbon fibers effectively improved all assessed mechanical properties of PA/CF composites. In particular, in XY build orientation, PA/CF 3D-printed composites exhibited a tensile strength of 96 MPa and a tensile modulus of 7.9 GPa, with an increment of + 34 and + 147%, respectively, when compared to the neat PA. Interlayer strength of 3D-printed PA and PA/CF composites reaches similar values, in the range 26-28 MPa. The impact strength of 3D-printed XY parts was reduced by the presence of CF. However, the fracture toughness of PA/CF composite 3D-printed parts was slightly higher in comparison with that of neat PA. Electrical resistivity of PA/CF 3D-printed parts is gradually decreasing from 1.7 × 104 to 0.7 × 104 Ω cm in the temperature range from − 16 to 100 °C. The piezoresistivity tests revealed that an exponential resistance change occurs for both compression-molded and 3D-printed PA/CF samples once strained in tension. A gauge factor of 3D-printed parts of about 65 ± 5 was determined from cyclic strains in the elastic region.
Is accurate routine cancer prognostication psychologically harmful? 5-year outcomes of life expectancy prognostication in uveal melanoma survivors
Authors: Brown Stephen L. , Fisher Peter , Hope-Stone Laura , Damato Bertil , Heimann Heinrich , Hussain Rumana , Cherry M. Gemma 
Published: April 2021

Abstract
Purpose
Prognostication in cancer is growing in importance as increasingly accurate tools are developed. Prognostic accuracy intensifies ethical concerns that a poor prognosis could be psychologically harmful to survivors. Uveal melanoma (UM) prognostication allows survivors to be reliably told that life expectancy is either normal (good prognosis) or severely curtailed because of metastatic disease (poor prognosis). Treatment cannot change life expectancy. To identify whether prognosis is associated with psychological harm, we compared harm in UM survivors with good and poor prognoses and those who declined testing and compared these outcomes to general population norms.

Methods
Non-randomized 5-year study of a consecutive series of 708 UM survivors (51.6% male, mean age 69.03, SD=12.12) with observations at 6, 12, 24, 36, 48 and 60 months. We operationalized psychological harm as anxiety and depression symptoms, worry about cancer recurrence (WREC) and poor quality of life (QoL).

Results
Compared to other groups, survivors with poor prognoses showed initially elevated anxiety and depression and consistently elevated worry about local or distant recurrence over 5 years. Good prognoses were not associated with outcomes. Generally, no prognostic groups reported anxiety, depression and WREC or QoL scores that exceeded general population norms.

Conclusions
Using a large sample, we found that harm accruing from a poor prognosis was statistically significant over 5 years, but did not exceed general non-cancer population norms.

Implications for Cancer Survivors
Survivors desire prognostic information. At a population level, we do not believe that our findings show sufficiently strong links between prognostication outcome and psychological harm to deny patients the option of knowing their prognosis. Nonetheless, it is important that patients are informed of potential adverse psychological consequences of a poor prognosis.
Unbounded Wiener–Hopf Operators and Isomorphic Singular Integral Operators
Authors: Castrigiano Domenico P. L. 
Published: April 2021

AbstractSome basics of a theory of unbounded Wiener–Hopf operators (WH) are developed. The alternative is shown that the domain of a WH is either zero or dense. The symbols for non-trivial WH are determined explicitly by an integrability property. WH are characterized by shift invariance. We study in detail WH with rational symbols showing that they are densely defined, closed and have finite dimensional kernels and deficiency spaces. The latter spaces as well as the domains, ranges, spectral and Fredholm points are explicitly determined. Another topic concerns semibounded WH. There is a canonical representation of a semibounded WH using a product of a closable operator and its adjoint. The Friedrichs extension is obtained replacing the operator by its closure. The polar decomposition gives rise to a Hilbert space isomorphism relating a semibounded WH to a singular integral operator of Hilbert transformation type. This remarkable relationship, which allows to transfer results and methods reciprocally, is new also in the thoroughly studied case of bounded WH.
Kant and Russell on Leibniz’ Existential Assertions
Authors: Rossi Alessandro 
Published: April 2021

AbstractLeibniz believed in a God that has the power to create beings and whose existence could be a priori demonstrated. Kant (KrV, A 592-602/B 620-630) objected that similar demonstrations all presuppose the false claim that existence is a real property. Russell (London and New York: Routledge, 1992) added that if existence were a real property Leibniz should have concluded that God does not actually have the power to create anything at all. First, I show that Leibniz’ conception of existence is incompatible with the one that Russell presupposes. Subsequently, I argue that on Leibniz’ conception of existence Russell’s objection is immediately undermined.
„So soll es sein“
Authors: Schmidt Holger 
Published: April 2021

ZusammenfassungAufgabe der Sozialen Arbeit ist auch die Reproduktion sozialer Normen. Dies geschieht in pädagogischen Normverhandlungen und setzt ein spezifisches Arbeitsverhältnis voraus, welches auf einer gegenseitigen Anerkennung beruht. Als fachliche Orientierung wird die negative Freiheit als normativer Horizont vorgeschlagen.
“The Earth Calculus”: Babbage, tables, and the calculating machine in the study of geology
Authors: Petrocelli Carla 
Published: April 2021

AbstractCharles Babbage is best known as a pioneer of computer science, but his contributions to the study of the Earth are not as well known. A curious and tireless traveler, on one of his trips to Italy, he dwelt on the remains of the Temple of Serapis, located about one-hundred feet from the coast of the small bay near Pozzuoli, south-west of Naples. On his return to England, also using his Difference Engine, he developed a theory to explain the phenomena related to the area of Serapeo, accompanied by illustrations and mathematical calculations, aimed at explaining the geological phenomena that had helped to make the site so interesting. With the same precision used for his calculation engine, Babbage proposed innovative techniques for the printing of diagrams and tables to be used in earth sciences. Just as his calculation engine had to be reliable by helping to eliminate human error, so the innovative techniques proposed had to allow a representation of geology as a reliable scientific experience.
Robust Landing Control of a Quadcopter on a Slanted Surface
Authors: Choi Jiwook , Cheon Donghun , Lee Jangmyung 
Published: April 2021

AbstractA robust landing control algorithm is proposed for a quadcopter, as well as for a landing platform to land on an inclined or problematic surface. To use the quadcopter for outdoor application, it is necessary to design a landing platform that can withstand environmental obstacles such as wind and weight load during landing. Conventional retractor landing platforms are not suitable for achieving a stable landing on inclined surfaces or obstacles. Therefore, in this paper, 2-link structured landing legs are applied to stably land on an inclined surface or obstacle with a suitable control algorithm. To achieve stable landing on a slanted surface, a cooperative control algorithm of the quadcopter and the landing platform has been proposed. The proposed robust landing system comprises two controllers, i.e., a high-speed proportional derivative control for the landing platform and a neural network-based proportional–integral–derivative control for controlling the quadcopter in real time. A quadcopter with a robust landing platform has been implemented, and the performance of the robust landing control algorithm has been demonstrated with the system.
An Interdisciplinary Perspective on the Value of Envy
Authors: Lange Jens , Protasi Sara 
Published: April 2021

AbstractThe public and scholars alike largely consider envy to be reprehensible. This judgment of the value of envy commonly results either from a limited understanding of the nature of envy or from a limited understanding of how to determine the value of phenomena. Overcoming this state requires an interdisciplinary collaboration of psychologists and philosophers. That is, broad empirical evidence regarding the nature of envy generated in psychological studies must inform judgments about the value of envy according to sophisticated philosophical standards. We conducted such a collaboration. Empirical research indicates that envy is constituted by multiple components which in turn predict diverse outcomes that may be functional for the self and society. Accordingly, the value of envy is similarly nuanced. Sometimes, envy may have instrumental value in promoting prudentially and morally good outcomes. Sometimes, envy may be non-instrumentally prudentially and morally good. Sometimes, envy may be bad. This nuanced perspective on the value of envy has implications for recommendations on how to deal with envy and paves the way toward future empirical and theoretical investigations on the nature and the value of envy.
Pharmaceutical design of a delivery system for the bacteriocin lacticin 3147
Authors: Ryan Aoibhín , Patel Pratikkumar , O’Connor Paula M. , Ross R. Paul , Hill Colin , Hudson Sarah P. 
Published: April 2021

Abstract
Lacticin 3147 is a dual-acting two-peptide bacteriocin which is generally active against Gram-positive bacteria, including Listeria monocytogenes and antimicrobial-resistant bacteria such as Closteroides difficile in the colon. L. monocytogenes infections can cause life-long effects in the elderly and vulnerable and can cause severe complications in pregnant women. C. difficile causes one of the most common healthcare-associated infections and can be fatal in vulnerable groups such as the elderly. Although lacticin 3147 is degraded by intestinal proteases and has poor aqueous solubility, encapsulation of the bacteriocin could enable its use as an antimicrobial for treating these bacterial infections locally in the gastrointestinal tract. Lacticin 3147 displayed activity in aqueous solutions at a range of pH values and in gastric and intestinal fluids. Exposure to trypsin and α-chymotrypsin resulted in complete inactivation, implying that lacticin 3147 should be protected from these enzymes to achieve successful local delivery to the gastrointestinal tract. The amount of lacticin 3147 dissolved, i.e. its solution concentration, in water or buffered solutions at pH 1.6 and 7.4 was low and varied with time but increased and was stabilized in gastrointestinal fluids by the phospholipid and bile salt components present. Thus, the feasibility of a solid lipid nanoparticle (SLN) delivery system for local administration of lacticin 3147 was investigated. Bacteriocin activity was observed after encapsulation and release from a lipid matrix. Moreover, activity was seen after exposure to degrading enzymes. Further optimization of SLN delivery systems could enable the successful pharmaceutical development of active lacticin 3147 as an alternative to traditional antibiotics.

Graphical abstract
Who Is Not Linking to HIV Care in Tennessee — the Benefits of an Intersectional Approach
Authors: Pierce Leslie J. , Rebeiro Peter , Brantley Meredith , Fields Errol L. , Jenkins Cathy A. , Griffith Derek M. , Conserve Donaldson , Shepherd Bryan , Wester Carolyn , Ahonkhai Aima A. 
Published: April 2021

Abstract
Introduction
Guided by an intersectional approach, we assessed the association between social categories (individual and combined) on time to linkage to HIV care in Tennessee.

Methods
Tennessee residents diagnosed with HIV from 2012-2016 were included in the analysis (n=3750). Linkage was defined by the first CD4 or HIV RNA test date after HIV diagnosis. We used Cox proportional hazards models to assess the association of time to linkage with individual-level variables. We modeled interactions between race, age, gender, and HIV acquisition risk factor (RF), to understand how these variables jointly influence linkage to care.

Results
Age, race, and gender/RF weAima A. Ahonkhaire strong individual (p < 0.001 for each) and joint predictors of time to linkage to HIV care (p < 0.001 for interaction). Older individuals were more likely to link to care (aHR comparing 40 vs. 30 years, 1.20, 95%CI 1.11-1.29). Blacks were less likely to link to care than Whites (aHR= 0.73, 95% CI: 0.67-0.79). Men who have sex with men (MSM) (aHR = 1.18, 95%CI: 1.03-1.34) and heterosexually active females (females) (aHR = 1.32, 95%CI: 1.14-1.53) were more likely to link to care than heterosexually active males. The three-way interaction between age, race, and gender/RF showed that Black males overall and young, heterosexually active Black males in particular were least likely to establish care.

Conclusions
Racial disparities persist in establishing HIV care in Tennessee, but data highlighting the combined influence of age, race, gender, and sexual orientation suggest that heterosexually active Black males should be an important focus of targeted interventions for linkage to HIV care.
Constraint multi-objective optimal design of hybrid renewable energy system considering load characteristics
Authors: Chen Yingfeng , Wang Rui , Ming Mengjun , Cheng Shi , Bao Yiping , Zhang Wensheng , Zhang Chi 
Published: April 2021

AbstractFinding the optimal size of a hybrid renewable energy system is certainly important. The problem is often modelled as an multi-objective optimization problem (MOP) in which objectives such as annualized system cost, loss of power supply probability etc. are minimized. However, the MOP model rarely takes the load characteristics into account. We argue that ignoring load characteristics may be inappropriate when designing HRES for a place with intermittent high load demand. For example, in a training base the load demand is high when there are training tasks while the demand decreases to a low level when there is no training task. This results in an interesting issue, that is, when the loss of power supply probability is determined at a specific value, say 15%, then it is very likely that most of loss of power supply would occur right in the training period which is unexpected. Therefore, this study proposes a constraint multi-objective model to deal with this issue—in addition to the general multi-objective optimization model, the loss of power supply probability over a critical period is set as a constraint. Correspondingly, the non-dominated sorting genetic algorithm II with a relaxed $$\epsilon $$
ϵ
constraint handling strategy is proposed to address the constraint MOP. Experimental results on a real world application demonstrate that the proposed model and algorithm are both effective and efficient.
Community Interest and the International Public Legal Order
Authors: Thin Sarah 
Published: April 2021

AbstractTraditional ideas about the private nature of the international legal order are increasingly being forced to contend with the development of public legal elements at the international level. The notion of the international community interest is key to understanding these developments and, as such, has transformed our understanding of international law. There are many different approaches to the public/private distinction in law, broadly categorised into relational, public authority, and interest-based approaches. These can be reduced to four key elements of publicness: the existence of a community or public; the universality of the public regime in question with its own boundaries; normative and institutional hierarchies; the objectivity of obligation and responsibility. The development of the community interest and related norms of international law can be seen to have introduced and strengthened all of these elements of publicness within the international legal system. It is thus on its way to becoming an international public legal order. This has important implications for our understanding of international law and the future development of the international legal order.
Corrosion Resistance of Selected Cast Iron Grades Under Deposit Mining Conditions
Authors: Stawarz Marcin , Dojka Malwina 
Published: April 2021

AbstractThe paper analyzes two types of alloyed cast iron used for pump impellers operated in mine working conditions. The research on corrosion resistance of two cast iron grades resistant to abrasive wear was presented. Tests were performed for chromium cast iron (HCCI) grade EN-GJN HV600 (XCr18) (acc. to EN 12513) and high-silicon cast iron HSCI Grade 1 (acc. to ASTM A 518/ A 518M - 99). Deposit mining is characterized by variable working conditions. Both types of cast iron are resistant to abrasive wear and are suitable for loaded elements (e.g. pump impellers). The paper presents a metallographic analysis of selected cast iron grades based on light microscopy. The chemical composition of the tested cast irons was determined with the Leco GDS 500 spectrometer; C and S content was determined with the CS125 Leco Carbon–Sulfur Determinator. The Si content for HSCI Grade 1 was determined by gravimetric method. Corrosion tests were performed under laboratory conditions. In-service tests of cast impellers were performed under real conditions (working mines applications). Corrosion resistance tests were measured with VoltaLab® Potentiostat (PGP 201). Performed tests resulted in the determination of the usefulness of materials used for dewatering pump impellers in mine working conditions. The results of laboratory tests were verified under the operating conditions of cast impellers. In the conditions of transporting a liquid-solid mixture at the moment of appearance of impurities (e.g. chlorine impurities) in the liquid, the impellers from cast iron HCCI revealed a tendency to pitting corrosion, which explains the exploitation results collected in the mining. After laboratory tests for sample from HCCI, the low value of breakdown potential Eb and repassivation Ecp was concluded which says about the absence of pitting corrosion resistance.
Evaluation of Data Errors and Monitoring Activities in a Trial in Japan Using a Risk-Based Approach Including Central Monitoring and Site Risk Assessment
Authors: Kondo Hidenobu , Kamiyoshihara Tomoaki , Fujisawa Kenji , Nojima Toshiaki , Tanigawa Ryohei , Fujiwara Hisataka , Suganami Hideki , Hayashi Yukikazu , Yamaguchi Takuhiro 
Published: April 2021

Abstract
Background
Risk-based monitoring (RBM) is a slow uptake in some trial sponsors. There are three main reasons for this. First, there is the fear of making large investments into advanced RBM technology solutions. Second, it is considered that RBM is most suitable for large, complex trials. Third, there is the fear of errors in both critical and non-critical data, appearing as reduced on-site monitoring is being conducted.

Methods
Our RBM team identified, evaluated, and mitigated trial risks, as well as devised a monitoring strategy. The clinical research associate (CRA) assessed the site risks, and the RBM team conducted central monitoring. We compared all data errors and on-site monitoring time between the partial switching sites [sites that had switched to partial source data verification (SDV) and source data review (SDR)] and the 100% SDV and SDR sites (sites that had implemented 100% SDV and SDR).

Results
Partial switching sites did not require any critical data correction and had a smaller number of data corrections through on-site monitoring than the 100% SDV and SDR sites. The RBM strategy reduced the on-site monitoring time by 30%.

Conclusions
The results suggest that RBM can be successfully implemented through the use of site risk assessment and central monitoring with practically no additional investment in technology and still produced similar results in terms of subject safety and data quality, as well as the cost savings that have been reported in global complex studies.
Deploying Health Care Providers During the COVID-19 Pandemic
Authors: Shander Aryeh , Mesrobian Jay , Weiss Jeffrey , Javidroozi Mazyar 
Published: April 2021

AbstractAs the COVID-19 pandemic runs its course around the globe, a mismatch of resources and needs arises: In some areas, health care systems are faced with an increased number of COVID-19 patients potentially exceeding their capacity, whereas, in other areas, health care systems are faced with procedural cancelations and a drop in demands. TeamHealth in Knoxville, Tennessee, a multidisciplinary health care organization, was able to roll out a systemic approach to redeploy its clinicians practicing in the fields of emergency medicine, hospital medicine, and anesthesiology from areas of less need (faced with reduced or no work) to areas outside of their normal practice facing immediate need.