bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timing of pacemaker and ICD implantation inLMNAmutation carriers
Authors: Ollila Laura Helena , Nikus Kjell , Parikka Hannu , Weckström Sini , Tiina Heliö 
Published: April 2021

AimsLMNA-cardiomyopathy is often associated with pathology in the cardiac conduction system necessitating device implantations. The aim was to study the timing and types of device implantations and need for re-implantations inLMNAmutation carriers.MethodsWe studied the hospital records of 60LMNAmutation carriers concerning device implantations and re-implantations and their indications. Data were collected until April 2019.ResultsThe median follow-up time from the first ECG recording to the last clinical follow-up, transplantation, or death was 7.7 (IQR=9.1) years. Altogether 61.7% (n=37) of theLMNAmutation carriers received a pacemaker or an implantable cardioverter defibrillator (ICD), and of them 27.0% (n=10) needed a device upgrade. Notably, in some patients the upgrade took place very soon after the first implantation. The first device was implanted at an average age of 47.9 years (SD=9.5), whereas the upgrade took place at an average age of 50.3 years (SD=8.1). Most upgrades were ICD implantations. Male patients underwent device upgrade more often and at a younger age than women. By the end of follow-up, 35.0% (n=21) of the patients fulfilled echocardiographic criteria for dilated cardiomyopathy, and 90.5% of them (n=19) needed pacemaker implantation.ConclusionMostLMNAmutation carriers underwent pacemaker implantation in this study. Due to the progressive nature ofLMNA-cardiomyopathy, device upgrades are quite common. An ICD should be considered when the initial device implantation is planned in anLMNAmutation carrier.
Taming the Wild Etext: Managing, Annotating, and Sharing Tibetan Corpora in Open Spaces
Authors: Trinley Ngawang , Tenzin  , Schmidt Dirk , Hildt Helios , Kaldan Tenzin 
Published: April 2021

Digital text is quickly becoming essential to modern daily life. The article you are reading right now is born digital; unlike texts of the not-so-distant past, it may never be printed at all. Worldwide, the trend is clear: Digital text is on the way in, and print is on its way out. Year-by-year, more and more readers are turning to ebooks, internet news, and other forms of ereading, while generation by generation, print is becoming less and less relevant.

1

1

Pew research shows 50% of Americans have a dedicated ereading device, with yearly gains in ereadership [1]; industry research, too, shows a definite trend toward ereading and non-traditional publishing, with ebooks making up 50% of fiction reading in 2016 [2], while journalism is also trending online [3].

These trends are not unique to English—to meet the demands and expectations of today's readers, Tibetan texts, too, are being digitized by many organizations and institutions with a shared appreciation for the Tibetan literary heritage. They include a variety of secular publishers, monastic institutions, and Buddhist foundations, among others. But while these organizations share common goals for common texts, their work is all too frequently completely disconnected from the community at large.
This situation negatively impacts what is already a minoritized and under-resourced language. While competition—from other languages, as well as other publishers in the Tibetan etext world—has been a driver of innovation in the adoption of ereading technology, we believe that a rich, shared data source is not only in everyone's best interest but also the only practical way forward when we consider the time, effort, expertise, and money that quality digitization takes.
That is why we have designed OpenPecha to be a public, open platform for collaborative etext curation and annotation sharing. Its aim is providing a wide range of users with the latest version of the exact “view” of any text needed, while maintaining the integrity of the text and its annotations and simultaneously allowing for community improvements and additions. In this article, we explore the details of how the project came to be, what it is, and how it works, while also presenting a few common use cases.
Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in
ANGPTL3
Authors: Blackburn Nicholas B. , Meikle Peter J. , Peralta Juan M. , Kumar Satish , Leandro Ana C. , Bellinger Melissa A. , Giles Corey , Huynh Kevin , Mahaney Michael C. , Göring Harald H.H. , VandeBerg John L. , Williams-Blangero Sarah , Glahn David C. , Duggirala Ravindranath , Blangero John , Michael Laura F. , Curran Joanne E. 
Published: April 2021

Background:
The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease is of fundamental importance given its global health and economic burden. Inhibition of ANGPTL3 (angiopoietin-like 3) has demonstrated a cardioprotective effect, showing promise for atherosclerotic cardiovascular disease treatment, and is currently the focus of ongoing clinical trials. Here, we assessed the genetic basis of variation in ANGPTL3 levels in the San Antonio Family Heart Study.

Methods:
We assayed ANGPTL3 protein levels in ≈1000 Mexican Americans from extended pedigrees. By drawing upon existing plasma lipidome profiles and genomic data we conducted analyses to understand the genetic basis to variation in ANGPTL3 protein levels, and accordingly the correlation with the plasma lipidome.

Results:

In a variance components framework, we identified that variation in ANGPTL3 was significantly heritable (h
2
=0.33,
P
=1.31×10
−16
). To explore the genetic basis of this heritability, we conducted a genome-wide linkage scan and identified significant linkage (logarithm of odds =6.18) to a locus on chromosome 1 at 90 centimorgans, corresponding to the
ANGPTL3
gene location. In the genomes of 23 individuals from a single pedigree, we identified a loss-of-function variant, rs398122988 (N121Kfs*2), in
ANGPTL3
, that was significantly associated with lower ANGPTL3 levels (β=−1.69 SD units,
P
=3.367×10
−13
), and accounted for the linkage signal at this locus. Given the known role of ANGPTL3 as an inhibitor of endothelial and lipoprotein lipase, we explored the association of ANGPTL3 protein levels and rs398122988 with the plasma lipidome and related phenotypes, identifying novel associations with phosphatidylinositols.

Conclusions:

Variation in ANGPTL3 protein levels is heritable and under significant genetic control. Both ANGPTL3 levels and loss-of-function variants in
ANGPTL3
have significant associations with the plasma lipidome. These findings further our understanding of ANGPTL3 as a therapeutic target for atherosclerotic cardiovascular disease.
Dislocating Heidegger: Nietzsche’s Presence in Derrida’s Geschlecht III
Authors: Schwab Philipp 
Published: April 2021

Abstract
The paper discusses the question as to whether, and in which way, Nietzsche is present in Derrida’s readings of Heidegger in the Geschlecht texts, and in the newly edited Geschlecht III specifically. In order to unfold the background of this question, the first part turns to earlier texts from the 1960s and 1970s and shows that Nietzsche is a key figure in Derrida’s takes on Heidegger, especially as regards the issue of Heidegger’s “belonging” to metaphysics. The second part then addresses the Geschlecht texts and makes the case that, despite their brevity and seeming marginality, the remarks on Nietzsche, most of all in Geschlecht III, are indeed illuminating, in mainly two regards: on the one hand, they shed some light on how Derrida reads and “dislocates” Heidegger in these texts overall, and on the other hand, they contribute to the question of a “continuity” in Derrida’s relations to Heidegger.
Merleau-Ponty’s Lectures on Heidegger
Authors: Low Douglas 
Published: April 2021

Abstract
Merleau-Ponty’s late lecture course on Heidegger is primarily concerned with probing the possibility of a phenomenological ontology. Merleau-Ponty’s lectures provide a rather straightforward presentation of Heidegger’s later thought, without elaborate commentary or criticism. However, Merleau-Ponty does favor Heidegger’s later move toward an indirect expression of Being but does not think that he consistently maintains this view. By the time that we reach the end of Merleau-Ponty’s lecture course, we begin to see a number of differences between the two philosophers come into play, with Merleau-Ponty’s philosophy solving more problems than that of his German counterpart.
Archaeology’s Offerings to Jesuit History
Authors: Cobb Charles R. 
Published: April 2021

Abstract
The contributions to the thematic issue of this journal address archaeological approaches to Jesuit missionizing in three contexts in the colonial Americas: substantial missions that also served as plantations, missions lacking full-time clergy, and short-term outposts on the edges of colonial empires. By relying on evidence from the landscape, the built environment, and objects, these studies demonstrate that the Jesuit enterprise was not subservient to, or a simple accomplice of, European colonial ambitions. Instead, missionizing by all Christian orders was intertwined with an evolution of both secular and religious philosophies that gave rise to modernity.
<p><strong>Studies on type material from Kützing’s diatom collection IV: The basionym, author and type of <em>Tetracyclus rupestre</em></strong></p>
Authors: WILLIAMS DAVID M. , SPAULDING SARAH A. , BISHOP IAN 
Published: April 2021

While describing the species Tetracyclus hinziae I. Bishop & Spaulding (2015, p. 200), it was noticed that the basionym and type specimens of the similar species Tetracyclus rupestre was unclear. This short note addresses those concerns.
Impacts of the North Atlantic Subtropical High on Daily Summer Precipitation over the Conterminous United States
Authors: Zorzetto Enrico , Li Laifang 
Published: April 2021

AbstractBy modulating the moisture flux from ocean to adjacent land, the North Atlantic Subtropical High (NASH) western ridge significantly influences summer-season total precipitation over the Conterminous United States (CONUS). However, its influence on the frequency and intensity of daily rainfall events over the CONUS remains unclear. Here we introduce a Bayesian statistical model to investigate the impacts of the NASH western ridge position on key statistics of daily-scale summer precipitation, including the intensity of rainfall events, the probability of precipitation occurrence, and the probability of extreme values. These statistical quantities play a key role in characterizing both the impact of wet extremes (e.g., the probability of floods) and dry extremes. By applying this model to historical rain gauge records (1948-2019) covering the entire CONUS, we find that the western ridge of the NASH influences the frequency of rainfall as well as the distribution of rainfall intensities over extended areas of the CONUS. In particular, we find that the NASH ridge also modulates the frequency of extreme rainfall, especially that over part of the Southeast and upper Midwest. Our analysis underlines the importance of including the NASH western ridge position as a predictor for key statistical rainfall properties to be used for hydrological applications. This result is especially relevant for projecting future changes in daily rainfall regimes over the CONUS based on the predicted strengthening of the NASH in a warming climate.
Cervical Cancer: Assessment of Its Knowledge, Utilization of Services and Its Determinant Among Female Undergraduate Students in a Low Resource Setting
Authors: Anikwe Chidebe Christian , Osuagwu Philip Chidubem , Ikeoha Cyril Chijioke , Ikechukwu Dimejesi Okechukwu B , Okorochukwu Bartholomew Chukwunonye 
Published: April 2021

Background Cervical cancer is a preventable disease that contributes significantly to the death of women. This study is aimed at determining the level of knowledge and utilization of cervical cancer screening and its determinants among female undergraduates of Ebonyi State University. Methods A structured questionnaire was used for a cross-sectional survey of the study population between January 1 and March 3, 2018. The data were analyzed using IBM SPSS Statistics version 20. Data were represented with frequency table, simple percentage, mode, range, Chi square and pie chart. The level of significance is at P-value < 0.05. Results Majority (74.8%) of the respondents were aware of cervical cancer and it could be prevented (70.8%). More than three-fifths (68.30%) were informed via health workers, and 86.8% were aware that post-coital vaginal bleeding is a symptom. Less than half (49.8%) knew that HPV is the primary cause, and only 32.9% were aware of the HPV vaccine. One-quarter of the respondent were aware that early coitarche is a risk factor for cervical cancer. Only 41.8% of the women were aware of Pap smear, 9.2% had undergone screening, and 97.6% were willing to be screened. Marital status was the significant determinant of being screened while class level did not significantly influence uptake of cervical cancer screening. The most common reason (20.6%) for not being screened was lack of awareness of the test. Conclusion Our study population had a good knowledge of cervical cancer, but utilization of cervical cancer screening was poor. Awareness creation through the mass media and provision of affordable screening services can promote the use of cervical cancer screening in the study area.
Test–retest reliability and criterion-related validity of Shih–Hsu test of attention between people with and without schizophrenia
Authors: Shih Yi-Nuo , Hsu Jia-Lien , Wang Yi-Ching , Wu Chia-Chun , Liao Yin-huang 
Published: April 2021

Introduction The “Shih–Hsu Test of Attention” (SHTA) is an iPad-based attention assessment tool developed in recent years by occupational therapists and has acceptable criterion-related validity and high test–retest reliability in preliminary application. This research project explores the criterion-related validity and test–retest reliability of SHTA between people with and without schizophrenia. Method The participants were 76 adults with schizophrenia aged 20–64 years, and 66 adults without diagnosed mental illness aged 20–64 years were recruited in this study on a voluntary basis. Each participant was assessed twice. The participants completed both the SHTA and Chu’s Attention Test (CAT) in the first test and the SHTA after 3 weeks. Findings Analytical results indicate that the SHTA has satisfactory test–retest reliability (ICC = 0.67) and criterion-related validity (γ = 0.29, p < 0.05*) for adults with schizophrenia and has high test–retest reliability (ICC = 0.90) and criterion-related validity (γ = 0.25, p < 0.05*) for adults without diagnosed mental illness. The MDC% value for the subjects without diagnosed mental illness was 12.1%, indicating acceptable random measurement error. Conclusion Our preliminary findings show that the iPad-based attention assessment tool, SHTA, has satisfactory criterion-related validity and test–retest reliability, supporting the future application of SHTA as an attention assessment tool.
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma
Authors: Verkleij Christie P. M. , Broekmans Marloes E. C. , van Duin Mark , Frerichs Kristine A. , Kuiper Rowan , de Jonge A. Vera , Kaiser Martin , Morgan Gareth , Axel Amy , Boominathan Rengasamy , Sendecki Jocelyn , Wong Amy , Verona Raluca I. , Sonneveld Pieter , Zweegman Sonja , Adams Homer C. , Mutis Tuna , van de Donk Niels W. C. J. 
Published: April 2021

Abstract
Cell surface expression levels of GPRC5D, an orphan G protein–coupled receptor, are significantly higher on multiple myeloma (MM) cells, compared with normal plasma cells or other immune cells, which renders it a promising target for immunotherapeutic strategies. The novel GPRC5D-targeting T-cell redirecting bispecific antibody, talquetamab, effectively kills GPRC5D+ MM cell lines in the presence of T cells from both healthy donors or heavily pretreated MM patients. In addition, talquetamab has potent anti-MM activity in bone marrow (BM) samples from 45 patients, including those with high-risk cytogenetic aberrations. There was no difference in talquetamab-mediated killing of MM cells from newly diagnosed, daratumumab-naïve relapsed/refractory (median of 3 prior therapies), and daratumumab-refractory (median of 6 prior therapies) MM patients. Tumor cell lysis was accompanied by T-cell activation and degranulation, as well as production of pro-inflammatory cytokines. High levels of GPRC5D and high effector:target ratio were associated with improved talquetamab-mediated lysis of MM cells, whereas an increased proportion of T cells expressing PD-1 or HLA-DR, and elevated regulatory T-cell (Treg) counts were associated with suboptimal killing. In cell line experiments, addition of Tregs to effector cells decreased MM cell lysis. Direct contact with bone marrow stromal cells also impaired the efficacy of talquetamab. Combination therapy with daratumumab or pomalidomide enhanced talquetamab-mediated lysis of primary MM cells in an additive fashion. In conclusion, we show that the GPRC5D-targeting T-cell redirecting bispecific antibody talquetamab is a promising novel antimyeloma agent. These results provide the preclinical rationale for ongoing studies with talquetamab in relapsed/refractory MM.
Efficacy and safety of apatinib in the treatment of osteosarcoma: a single-arm meta-analysis among Chinese patients
Authors: Yao Hui , Chen Xuyu , Tan Xiaodong 
Published: April 2021

Abstract
Background
Osteosarcoma is a relatively rare malignant tumor with a high incidence in young people. The development of tyrosine kinase inhibitors has brought the treatment of osteosarcoma into a new stage. Apatinib, a tyrosine kinase inhibitor specifically targeting VEGFR2, has been increasingly reported as a treatment for osteosarcoma with promising outcome parameters, but there has been no systematic analysis of the treatment of osteosarcoma by apatinib.

Methods
A single-arm meta-analysis was performed, and published literature from PubMed, Web of Science, Embase, Cochrane Library, CNKI and Wan Fang databases as of March 1, 2021 was systematically retrieved. Quality assessment is carried out in accordance with a 20 item checklist form prepared by the Institute of Health Economics (IHE). Double arcsine transformation is performed to stabilize the variance of the original ratio. When I2 > 50%, the random effect model is used to calculate the pooled parameters; otherwise, the fixed effect model is used. We conducted subgroup analysis according to age and apatinib dose.

Results
This meta-analysis included 11 studies of 356 Chinese patients with osteosarcoma. The pooled objective remission rate (ORR) of advanced or metastatic osteosarcoma treated by oral apatinib in Chinese patients was 0.27(95%CI = 0.18–0.38). The pooled disease control rate (DCR) was 0.57 (95%CI = 0.42–0.72). The pooled median progression-free survival (mPFS) and median total survival (mOS) were 5.18 months (95%CI = 4.03–6.33) and 10.87 months (95% CI = 9.40–12.33), respectively. More than 70% of adverse reactions were mild, the most common adverse reaction was hand-foot syndrome (HFMD), with an incidence of 0.46 (95%CI = 0.35–0.58), the second was hypertension, with an incidence of 0.40 (95%CI = 0.29–0.51).

Conclusions
The efficacy of apatinib in the treatment of osteosarcoma is competitive with current evidence, and it is worth noting that its low cost can significantly improve patient compliance and increase therapeutic value.
Healthcare professionals in research (HPiR) Facebook community: a survey of U.K. doctoral and postdoctoral healthcare professionals outside of medicine
Authors: Deane J. A. , Clunie G. 
Published: April 2021

Abstract
Background
Healthcare professionals outside of medicine (HCPs), including nurses, midwives and allied health professionals, are increasingly involved in research for patient benefit. Their challenge is to negotiate inter-professional or professionally isolated contexts. The aims of this study were to evaluate the ‘Healthcare Professionals in Research’ (HPiR) Facebook group (a self-directed and confidential peer support group for doctoral and postdoctoral HCPs) including engagement, the experiences of doctoral and postdoctoral HPiR members and to identify future career challenges using an on-line survey.

Methods
The HPiR Facebook group was launched in May 2019. Five HCP Community managers (CMs) were trained in on-line platform curation, moderation and screening. An on-line survey was designed to capture data from HPiR members. A purposive sampling approach was applied. Respondents were required to be doctoral and postdoctoral HCPs and a registered member of the HPiR group. Respondents represented a range of healthcare professions, 79 % of whom had over ten years clinical experience. Membership growth and engagement was analysed. Descriptive statistics were used to present numerical data. Qualitative data were analysed thematically.

Results
96 members were admitted to the group within the first month. All members were actively engaged with group content. 34/96 doctoral and postdoctoral HCPs completed the survey. Most members joined for networking (88 %) and peer support (82 %) purposes. Analysis of text responses showed difficulties in balancing a clinical academic career and highlighted the consequences of undefined clinical academic roles and pathways.

Conclusions
Doctoral and postdoctoral HCPs value the opportunities that HPiR provides for peer support and connection with fellow HCPs. HPiR has the potential to strengthen research capacity, support research skill development and drive change within the clinical academic community. Clinical academic roles and pathways need to be standardised. The creation of opportunities beyond doctoral studies is a priority.
Development of recombinase polymerase amplification assays for rapid and visual detection of canine distemper virus infecting giant panda
Authors: Huang Pei , Yu Yue , Meng Xianyong , Wang Tiecheng , Yan Feihu , Li Entao , Shi Zhikang , He Hongbin , Yang Songtao , Xia Xianzhu , Wang Jianzhong , Feng Na 
Published: April 2021

Abstract
Background
Canine distemper virus (CDV) is an enveloped negative-strand RNA virus that exhibits a high mutation rate and continuously expands the range of hosts. Notably, CDV has infected giant panda with spill over from viral reservoirs in canines. Giant pandas (Ailuropoda melanoleuca), especially captive pandas, are known to be susceptible to natural infection with CDV. The high fatality rate of CDV poses a serious threat to the safety of the giant panda population. However, vaccines or drugs for canine distemper in giant pandas have not been developed to date. Therefore, a rapid test that can achieve accurate onsite detection of CDV is important to enable the timely implementation of control measures. In this study, we established a nucleic acid visualization assay for targeting the CDV N gene by using combines reverse transcription recombinase polymerase amplification with a closed vertical flow visualization strip (RT-RPA-VF).

Results
The RT-RPA-VF assay does not require sophisticated equipment, and it was determined to provide rapid detection at 35 °C for 30 min, while the limit of detection was 5 × 101 copies/μl RNA transcripts and 100.5 TCID50 ml− 1 viruses. The results showed that the assay was high specific to CDV and had no cross-reactivity with other viruses infecting the giant panda. Compared with RT-qPCR, RT-RPA-VF assay had a sensitivity of 100% and a specificity of 100% in 29 clinical samples. The coincidence rate between RT-RPA-VF and RT-qPCR was 100% (kappa = 1), indicating that the RT-RPA-VF assay possessed good diagnostic performance on clinical samples.

Conclusions
The RT-RPA-VF provides a novel alternative for the simple, sensitive, and specific identification of CDV and showed great potential for point of care diagnostics for captive and wild giant panda.