bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIAGNÓSTICO ORGANIZACIONAL COMO FERRAMENTA ESTRATÉGICA NA GESTÃO DE PESSOAS – ESTUDO EM EMPRESA CATARINENSE DO RAMO IMOBILIÁRIO
Authors: Lucas dos Santos Geneia , Prá Raquel , Pereira Moraes Jhony , Da Silva Michelle 
Published: February 2021

A precedência de uma análise da situação organizacional interna é um requisito para realizar o planejamento de ações voltadas para a Gestão Estratégica de Pessoas que sustentem o atingimento da estratégia empresarial. Para tanto, as ferramentas de diagnóstico organizacional, como a proposta com Krausz (1994), são valiosas. Com base nesta constatação, surge o presente estudo com o objetivo de, através da aplicação da ferramenta citada, propor melhorias para os processos de Gestão de Pessoas de uma empresa de pequeno porte localizada na cidade de Caçador, Santa Catarina. Trata-se de uma pesquisa exploratória envolvendo a aplicação de um questionário (levantamento). Os resultados da aplicação da ferramenta demonstram a necessidade de atuação sobre aspectos como relacionamentos intra e interequipes, comunicação, liderança e clima organizacional, os quais são de significativa importância para garantir o comprometimento dos colaboradores com as metas organizacionais.
Palavras-chave: Diagnóstico Organizacional; Gestão Estratégica de Pessoas; Clima Organizacional; Motivação; Relações Interpessoais.

Abstract: The precedence of an analysis of the internal organizational situation is a requirement to carry out the planning of actions aimed for the People's Strategic Management, that sustain the achievement of the business strategy. To this objective, organizational diagnostic tools, such as the one proposed by Krausz (1994), are valuable. Based on this observation, the present study aims to propose improvements to the Personnel Management processes of a small company located in the city of Caçador, Santa Catarina, through the application of the mentioned tool. This is an exploratory survey involving the application of a questionnaire. The results of the application of the tool demonstrate the need to act on aspects, such as intra and intercompany relationships, communication, leadership and organizational climate, which have significant importance to guarantee the commitment of employees into organizational goals.
Keywords: Organizational Diagnosis; Strategic Management of People; Organizational Climate; Motivation; Relationships.
Attitudes Toward Epilepsy Among Parents of Children With Epilepsy in Southern China
Authors: Yang Haojun , Chi Yunfang , Zhu Ziqing , Huang Kailing , Xiang Lan , Xiao Bo , Tang Weiting , Feng Li 
Published: February 2021

Purpose: To evaluate the attitudes toward epilepsy among parents of children with epilepsy (CWE) in China and identify some related factors for future interventions for parents to offer more social support for CWE.Method: The Chinese Public Attitudes Toward Epilepsy (CPATE) scale was administered to 234 parents of CWE and 203 parents of normal children in Xiangya hospital during 2019–2020.Results: The cumulative score of the parents of CWE (26.427 ± 6.688) was significantly lower than that of the normal children group (32.330 ± 7.234, p &lt; 0.001). Subanalysis showed more positive attitudes among parents of CWE than the control group (p &lt; 0.001) toward education (4.765 ± 1.985 vs. 6.621 ± 2.419), social life (6.556 ± 2.456 vs. 8.010 ± 2.683), marriage (9.586 ± 2.675 vs. 11.025 ± 2.900), and employment (3.876 ± 1.364 vs. 4.5123 ± 1.283). The attitudes toward epilepsy among parents of CWE with seizures in public (27.16 ± 6.66) or during sleep (27.10 ± 6.38) were more negative than those without (25.35 ± 6.62 and 25.08 ± 7.10, respectively) (p &lt; 0.05). In addition, female and low income were negatively related to parents' attitudes toward epilepsy.Conclusions: More active policy guidance and adequate social support should be given to parents of children with seizures in public or during sleep to instruct their children to form a positive perception about epilepsy, which is expected to have a positive impact on their social abilities in the future.
No Impact of Cerebellar Anodal Transcranial Direct Current Stimulation at Three Different Timings on Motor Learning in a Sequential Finger-Tapping Task
Authors: Nguemeni Carine , Stiehl Annika , Hiew Shawn , Zeller Daniel 
Published: February 2021

Background: Recently, attention has grown toward cerebellar neuromodulation in motor learning using transcranial direct current stimulation (tDCS). An important point of discussion regarding this modulation is the optimal timing of tDCS, as this parameter could significantly influence the outcome. Hence, this study aimed to investigate the effects of the timing of cerebellar anodal tDCS (ca-tDCS) on motor learning using a sequential finger-tapping task (FTT).Methods: One hundred and twenty two healthy young, right-handed subjects (96 females) were randomized into four groups (Duringsham, Before, Duringreal, After). They performed 2 days of FTT with their non-dominant hand on a custom keyboard. The task consisted of 40 s of typing followed by 20 s rest. Each participant received ca-tDCS (2 mA, sponge electrodes of 25 cm2, 20 min) at the appropriate timing and performed 20 trials on the first day (T1, 20 min). On the following day, only 10 trials of FTT were performed without tDCS (T2, 10 min). Motor skill performance and retention were assessed.Results: All participants showed a time-dependent increase in learning. Motor performance was not different between groups at the end of T1 (p = 0.59). ca-tDCS did not facilitate the retention of the motor skill in the FTT at T2 (p = 0.27). Thus, our findings indicate an absence of the effect of ca-tDCS on motor performance or retention of the FTT independently from the timing of stimulation.Conclusion: The present results suggest that the outcome of ca-tDCS is highly dependent on the task and stimulation parameters. Future studies need to establish a clear basis for the successful and reproducible clinical application of ca-tDCS.
Population Pharmacokinetics and Exposure–Safety Relationship of Paclitaxel Liposome in Patients With Non-small Cell Lung Cancer
Authors: Zhou Haiyan , Yan Jiaqing , Chen Wei , Yang Jun , Liu Min , Zhang Yuan , Shen Xin , Ma Yinglin , Hu Xingsheng , Wang Yan , Du Kehe , Li Guohui 
Published: February 2021

PurposePaclitaxel liposome (Lipusu) is the first commercialized liposomal formulation of paclitaxel. There has been little data collected on the pharmacokinetics (PK) of paclitaxel liposome, especially in relation to patient use. This study aimed to build a population pharmacokinetic (PopPK) model and further explore the exposure–safety relationship for paclitaxel liposome in patients with non-small cell lung cancer (NSCLC).MethodsData from 45 patients with a total of 349 plasma concentrations were analyzed. The PopPK model was built using the non-linear mixed effect modeling technique.ResultsThe PK of paclitaxel liposome were well described by a three-compartment model with first-order elimination. For a dose of 175 mg m–2, the estimated clearance of total plasma paclitaxel was 21.55 L h–1. Age, sex, body weight, total bilirubin, albumin, serum creatinine, and creatinine clearance did not influence the paclitaxel PK. Exposure to paclitaxel had no significant change in the presence of the traditional Chinese medicine, aidi injection. The exploratory exposure–safety relationship was well described by a generalized linear regression model. Higher probabilities of grade &gt;1 neutropenia were observed in patients with higher exposure to paclitaxel.ConclusionThis PopPK model adequately described the PK of paclitaxel liposome in patients with NSCLC. Predicted exposure of paclitaxel did not change in the presence of the traditional Chinese medicine, aidi injection. The exposure–safety analysis suggested that a higher risk of neutropenia was correlated with higher exposure to paclitaxel.
Identification and Validation of an Autophagy-Related lncRNA Signature for Patients With Breast Cancer
Authors: Zhang Ruyue , Zhu Qingwen , Yin Detao , Yang Zhe , Guo Jinxiu , Zhang Jingmin , Zhou Yubing , Yu Jane J. 
Published: February 2021

BackgroundAutophagy is a “self-feeding” phenomenon of cells, which is crucial in mammalian development. Long non-coding RNA (lncRNA) is a new regulatory factor for cell autophagy, which can regulate the process of autophagy to affect tumor progression. However, poor attention has been paid to the roles of autophagy-related lncRNAs in breast cancer.ObjectiveThis study aimed to construct an autophagy-related lncRNA signature that can effectively predict the prognosis of breast cancer patients and explore the potential functions of these lncRNAs.MethodsThe RNA sequencing (RNA-Seq) data of breast cancer patients was collected from The Cancer Genome Atlas (TCGA) database and the GSE20685 database. Multivariate Cox analysis was implemented to produce an autophagy-related lncRNA signature in the TCGA cohort. The signature was then validated in the GSE20685 cohort. The receiver operator characteristic (ROC) curve was performed to evaluate the predictive ability of the signature. Gene set enrichment analysis (GSEA) was used to explore the potential functions based on the signature. Finally, the study developed a nomogram and internal verification based on the autophagy-related lncRNAs.ResultsA signature composed of 9 autophagy-related lncRNAs was determined as a prognostic model, and 1,109 breast cancer patients were divided into high-risk group and low-risk group based on median risk score of the signature. Further analysis demonstrated that the over survival (OS) of breast cancer patients in the high-risk group was poorer than that in the low-risk group based on the prognostic signature. The area under the curve (AUC) of ROC curve verified the sensitivity and specificity of this signature. Additionally, we confirmed the signature is an independent factor and found it may be correlated to the progression of breast cancer. GSEA showed gene sets were notably enriched in carcinogenic activation pathways and autophagy-related pathways. The qRT-PCR identified 5 lncRNAs with significantly differential expression in breast cancer cells based on the 9 lncRNAs of the prognostic model, and the results were consistent with the tissues.ConclusionIn summary, our signature has potential predictive value in the prognosis of breast cancer and these autophagy-related lncRNAs may play significant roles in the diagnosis and treatment of breast cancer.
Health Literacy and Quality of Life in Young Adults From The Belgian Crohn's Disease Registry Compared to Type 1 Diabetes Mellitus
Authors: Carels Constance , Wauters Lucas , Outtier An , Baert Filip , Bossuyt Peter , Colard Arnaud , De Looze Danny , Ferrante Marc , Goegebuer Alexander , Hauser Bruno , Hilbrands Robert , Hoffman Ilse , Keymeulen Bart , Paquot Isabelle , Ruytjens Isabelle , Simoens Marc , Thienpont Clara , Verreth Annelies , Verstockt Bram , Vermeire Séverine , Veereman Gigi 
Published: February 2021

Background and Aims: The management of chronic inflammatory bowel diseases in youth is challenging. We aimed to determine health literacy (HL), quality of life (QoL) and clinical outcomes in young adults from the BELgian CROhn's disease registry (BELCRO) in comparison to type 1 diabetes mellitus (DM) as a control.Methods: In this prospective and observational study, young adults with Crohn's disease (CD) diagnosed &lt; 18 years and with &gt; 5 years disease duration and a comparable group of patients with DM completed validated HL, QoL and work productivity and activity impairment questionnaires (HLS-EU-Q16, EQ-5D-5L and WPAI). HL was scored as sufficient (13–16), problematic (9–12) or inadequate (0–8). QoL was dichotomized into “no problems” (EQ-5D level 1) or “problems” (EQ-5D levels 2 to 5). Non-parametric (Mann-Whitney U) analyses and Spearman correlations were performed.Results: A total of 52 CD (median [IQR] age of 25.0 [23.8-27.0], 64% male) and 50 DM (age 20.0 [19.0-22.0], 50% male) patients were included. HL was 14.0 [11.0-16.0] for CD and 14.0 [11.3-14.8] for DM (p = 0.6) with similar proportions of sufficient (60 vs. 68%, p = 0.4), problematic (34 vs. 26%, p = 0.3) and inadequate HL (both 6%, p = 1). Although QoL was comparable for CD and DM (77.0 [68.8-82.0] vs. 75.0 [65.0-80.0] %, p =0.4), CD had a trend for higher pain/discomfort (50 vs. 32%, p = 0.06). HL and QoL correlated in CD (r = 0.6, p &lt; 0.001) and DM patients (r = 0.6, p &lt; 0.001). Fewer CD patients with recent hospitalization/surgery had sufficient HL (31 vs. 69%, p = 0.01) and had lower QoL (70.0 [60.0-77.0] vs. 80.0 [70.0-85.0], p = 0.04) compared to those without.Conclusions: Selected young Belgian adults suffering from CD for &gt;5 years have similar and sufficient HL compared to DM patients. However, CD patients requiring hospitalization/surgery have lower HL, which indicates the need for targeted educational programs.
Hospitalization Expenditures and Out-Of-Pocket Expenses in Patients With Stroke in Northeast China, 2015–2017: A Pooled Cross-Sectional Study
Authors: Ma Zihua , Deng Gongman , Meng Zhaolin , Wu Huazhang 
Published: February 2021

Background: Stroke is the second most common cause of mortality worldwide and the leading cause of death in China. It imposes a heavy financial burden on patients, especially for some social groups that are vulnerable to economic risks.Objective: This study aimed to comprehensively assess the magnitude of hospital and out-of-pocket (OOP) costs associated with stroke in Northeast China.Methods: Patients were selected via a multistage stratified cluster random sampling approach. We reviewed all patients’ records from 39 hospitals across six cities in Liaoning Province between 2015 and 2017. Cost characteristics of four major stroke types were analyzed. Multivariate linear regression analyses were employed to examine the determinants of hospitalization costs and OOP expenses.Results: A total of 138,757 patients were assessed for the medical costs. The mean hospitalization costs were $1,627, while the mean OOP expenses were $691, accounting for 42.5% of the total expenditures. Medication expenses were the largest contributor to hospitalization costs. The regression analysis suggested that age, length of stay (LOS), social identity, type of stroke, surgery, intensive care unit (ICU) admission, hospital level and hospital type were significantly correlated with hospitalization costs and OOP expenses.Conclusion: Stroke imposes a heavy financial burden on both patients and society in Liaoning Province, Northeast China. Results showed that there are some differences in the individual and social economic burden among different types of stroke. In addition, stroke patients share a high proportion of costs through OOP expenses, especially for poor social-economic status patients. Targeted intervention measures and specific policies are needed to reduce the individual and social economic burden of stroke as well as improve equity in health care among different social groups.
Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
Authors: Xiong Hua-Long , Cao Jia-Li , Shen Chen-Guang , Ma Jian , Qiao Xiao-Yang , Shi Tian-Shu , Ge Sheng-Xiang , Ye Hui-Ming , Zhang Jun , Yuan Quan , Zhang Tian-Ying , Xia Ning-Shao 
Published: February 2021

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.
Heart Rate Dynamics During Acute Recovery From Maximal Aerobic Exercise in Young Adults
Authors: Berry Nathaniel T. , Bechke Emily , Shriver Lenka H. , Calkins Susan D. , Keane Susan P. , Shanahan Lilly , Wideman Laurie 
Published: February 2021

IntroductionResting heart rate (HRrest), heart rate variability (HRV), and HR recovery (HRR) from exercise provide valuable information about cardiac autonomic control. RR-intervals during acute recovery from exercise (RRrec) are commonly excluded from HRV analyses due to issues of non-stationarity. However, the variability and complexity within these trends may provide valuable information about changes in HR dynamics.PurposeAssess the complexity of RRrec and determine what physiologic and demographic information are associated with differences in these indices in young adults.MethodsRR-intervals were collected throughout maximal treadmill exercise and recovery in young adults (n = 92). The first 5 min of RRrec were (1) analyzed with previously reported methods that use 3-interval lengths for comparison and (2) detrended using both differencing(diff) and polynomial regression(res). The standard deviation of the normal interval (SDNN), root mean square of successive differences (rMSSD), root mean square (RMS) of the residual of regression, and sample entropy (SampEn) were calculated. Repeated measures analysis of covariance (ANCOVA) tested for differences in these indices for each of the methodological approaches, controlling for race, body fat, peak oxygen uptake (VO2peak), and resting HR (HRrest). Statistical significance was set at p &lt; 0.05.ResultsVO2peak and HRrest were significantly correlated with traditional measures of HRR and the variability surrounding RRrec. SampEndiff and SampEnres were correlated with VO2peak but not HRrest or HRR. The residual-method provided a significantly (p = 0.04) lower mean standard error (MSE) (0.064 ± 0.042) compared to the differencing-method (0.100 ± 0.033).ConclusionsComplexity analysis of RRrec provides unique information about cardiac autonomic regulation immediately following the cessation of exercise when compared to traditional measures of HRR and both HRrest and VO2peak influence these results.
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study
Authors: Hu Je-Ming , Lee Chia-Cheng , Lin Tzu-Chiao , Chung Chi-Hsiang , Chen Chao-Yang , Chang Pi-Kai , Hsiao Cheng-Wen , Sun Chien-An , Tzeng Nian-Sheng , Chien Wu-Chien 
Published: February 2021

Background: The association between attention-deficit hypersensitivity disorder (ADHD) and the risk of developing colorectal cancer (CRC) is, as yet, to be investigated, and thus, we have conducted this nationwide, cohort study to examine the association in patients from Taiwan.Methods: In this study, 798 individuals with newly diagnosed ADHD and 2,394 (1:3) age-, gender-, and index year- matched controls without ADHD were enrolled, between 2000 and 2013, from the Longitudinal Health Insurance Database, a subset of the National Health Insurance Research Database in Taiwan. The cumulative incidence of CRC was assessed in each cohort by the Kaplan–Meier method. The multivariate Cox proportional hazards model was used to estimate the crude, and the adjusted hazards ratios (HRs) with 95% confidence intervals (CIs), was conducted to estimate the association between ADHD and CRC.Results: The Kaplan–Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with ADHD than in those without it (log rank test, p &lt; 0.001). After adjustments for age, gender, comorbidities, and other covariates, the ADHD group was associated with an increased risk of CRC in comparison to the non-ADHD group (adjusted HR = 3.458, 95% CI = 1.640–7.293, p &lt; 0.001). In addition, the usage of methylphenidate was not associated with the risk of developing CRC in patients with ADHD.Conclusion: This retrospective cohort study depicts the evidence that ADHD was associated with the increased risk of CRC. Further studies are needed to confirm the association and the underlying mechanisms.
Police Encounters, Agitation, Diagnosis, and Employment Predict Psychiatric Hospitalisation of Intensive Home Treatment Patients During a Psychiatric Crisis
Authors: Barakat Ansam , Blankers Matthijs , Cornelis Jurgen E. , van der Post Louk , Lommerse Nick M. , Beekman Aartjan T. F. , Dekker Jack J. M. 
Published: February 2021

Objective: This study aims to determine factors associated with psychiatric hospitalisation of patients treated for an acute psychiatric crisis who had access to intensive home treatment (IHT).Methods: This study was performed using data from a randomised controlled trial. Interviews, digital health records and eight internationally validated questionnaires were used to collect data from patients on the verge of an acute psychiatric crisis enrolled from two mental health organisations. Thirty-eight factors were assigned to seven risk domains. The seven domains are “sociodemographic”, “social engagement”, “diagnosis and psychopathology”, “aggression”, “substance use”, “mental health services” and “quality of life”. Multiple logistic regression analysis (MLRA) was conducted to assess how much pseudo variance in hospitalisation these seven domains explained. Forward MLRA was used to identify individual risk factors associated with hospitalisation. Risks were expressed in terms of relative risk (RR) and absolute risk difference (ARD).Results: Data from 183 participants were used. The mean age of the participants was 40.03 (SD 12.71), 57.4% was female, 78.9% was born in the Netherlands and 51.4% was employed. The range of explained variance for the domains related to “psychopathology and care” was between 0.34 and 0.08. The “aggression” domain explained the highest proportion (R2 = 0.34) of the variance in hospitalisation. “Quality of life” had the lowest explained proportion of variance (R2 = 0.05). The forward MLRA identified four predictive factors for hospitalisation: previous contact with the police or judiciary (OR = 7.55, 95% CI = 1.10–51.63; ARD = 0.24; RR = 1.47), agitation (OR = 2.80, 95% CI = 1.02–7.72; ARD = 0.22; RR = 1.36), schizophrenia spectrum and other psychotic disorders (OR = 22.22, 95% CI = 1.74–284.54; ARD = 0.31; RR = 1.50) and employment status (OR = 0.10, 95% CI = 0.01–0.63; ARD = −0.28; RR = 0.66).Conclusion: IHT teams should be aware of patients who have histories of encounters with the police/judiciary or were agitated at outset of treatment. As those patients benefit less from IHT due to the higher risk of hospitalisation. Moreover, type of diagnoses and employment status play an important role in predicting hospitalisation.