bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Analysis of Molds with Conformal Cooling Channels: A Numerical Study
Authors: Silva Hugo Miguel , Noversa Tiago , Rodrigues Hugo , Fernandes Leandro , Pontes António 
Published: November 2021

Abstract
The manufacturing of Conformal cooling channels (CCC’s) is now easier and more affordable, owing to the recent developments in the field of additive manufacturing. The use of CCC’s allows better cooling performances than the conventional (straight-drilled) channels, in the injection molding process. The main reason is that CCC’s can follow the pathways of the molded geometry, while the conventional channels, manufactured by traditional machining techniques, are not able to. Using CCCs can significantly improve the cycle time, allow to obtain a more uniform temperature distribution, and reduce thermal stresses and warpage. However, the design process for CCC is more complex than for conventional channels. Computer-aided engineering (CAE) simulations are important for achieving effective and affordable design. This article presents important results regarding molds with new conformal cooling channels geometries. The aim is to assess the maximum pressure that the parts can be subjected to in a real injection molding application. Linear structural analyses are carried over in the Finite Element Method Software ANSYS Workbench 2020 R2, in order to analyze both the resistance and stiffness behavior of the studied geometries. The results are analyzed according to several metrics. The results were discussed and it could be concluded that some of the structures are suitable for the typical operating conditions of the injection molding process.
Introduction to the native plant species with phytoremediation potential growing in a high Fe and Zn contaminated site in the copper mine of Dehmadan, Iran
Authors: Hajihashemi Shokoofeh , Rajabpoor Shakiba , Brestic Marian 
Published: November 2021

Abstract
Mining activity is one main source of heavy metal pollution. In this study, Al, Ba, Be, Ca, Cd, Co, Ce, Cr, Cu, Fe, Ga, Gd, K, La, Li, Mg, Mn, Na, Nb, Nd, Ni, P, Pb, S, Sc, Si, Sr, Ti, V, Y, Zn and Zr were measured by ICP-OES analyzing of the soils taken in the Dehmadan mining area, Chaharmahal and Bakhtiari, Iran. Al, Fe, Cu, Si and Zn were the most frequent metals in the mining area. Phytoremediation is one of the eco-friendly methods to effectively remediate soils contaminated with heavy metals. Consequently, the wild plants were collected from the mining area and subjected to ICP-OES analysis to determine the elements concentrations. A reverse relation was observed between the metals concentrations and vegetation density in the mining area. Finally, the bioconcentration factor (BCF) of the root and shoot, and translocation factor (TF) were determined to assess phytoremediation potential of species. The shoot elements concentrations in combination with BCF and TF greater than 1 were assess to determine hyperaccumulators and plants with excluder potential. Overall, the results showed that BCF in parallel with TF and metals concentrations can advance the knowledge of recognizing hyperaccumulators for phytoremediation of polluted environment.
The pronounced decline of anti-SARS-CoV-2 spike trimeric IgG and RBD IgG in baseline seronegative individuals 6 months after BNT162b2 vaccination is consistent with the need for vaccine boosters
Authors: Salvagno Gian Luca , Henry Brandon M. , Pighi Laura , De Nitto Simone , Gianfilippi Gianluca , Lippi Giuseppe 
Published: November 2021

Abstract
Background: This observational retrospective study aimed to define the kinetics of serum levels of anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike trimeric and anti-receptor binding domain (RBD) IgG antibodies up to 6 months after BNT162b2 vaccination. Methods: The sample consisted of 86 SARS-CoV-2 baseline seronegative subjects (median age 45 years, IQR 31-53 years; 52.3% females) undergoing vaccination with Pfizer/BioNTech BNT162b2. Blood was drawn before receiving the first and the second vaccine dose, as well as 1, 3 and 6 months after the second vaccine dose. The serum levels of anti-SARS-CoV-2 spike trimeric IgG and RBD IgG antibodies were assayed.Results: The peak of both antibodies types was reached 1 month after the second dose (2808 and 2163 BAU/mL for anti-SARS-CoV-2 spike trimeric IgG and RBD IgG), after which serum levels progressively declined, falling after 6 months to 486 BAU/mL and 167 BAU/mL for anti-SARS-CoV-2 spike trimeric IgG and RBD IgG, respectively. The median rate of 6-month decline was 85% and 93% for anti-SARS-CoV-2 spike trimeric IgG and RBD IgG, respectively. The rate of vaccine recipients with serum antibodies levels above the 80% threshold of vaccine efficacy declined from over 95% at the peak to 72% and 5% at 6 months for anti-SARS-CoV-2 spike trimeric IgG and RBD IgG, respectively.Conclusions: The results of this retrospective observational study are consistent with the need for timely administration of vaccine boosters to prevent that humoral immunity will wane.
Temperate Regenerative Agriculture; a win-win for soil carbon and crop yield?
Authors: Jordon Matthew , Willis Kathy , Bürkner Paul-Christian , Haddaway Neal , Smith Pete , Petrokofsky Gillian 
Published: November 2021

Abstract
Regenerative Agriculture proposes to contribute to climate change mitigation and increased food production through improved yields by building soil organic carbon (SOC). We examine three Regenerative practices: reducing tillage intensity, cover cropping and including a grass-based phase in arable rotations (ley-arable systems). Our Bayesian meta-analysis of 195 paired SOC and crop yield observations from published studies finds statistically significant increases in SOC concentration for reduced tillage intensity (0.06 g C.100g-1) and ley-arable systems (0.05 g C.100-1g per year of ley) compared to conventional practice over an average study duration of 15 years, but no effect of cover crops. None of these practices come at a cost to yield during cropping years. However, we find no evidence of a win-win between soil carbon sequestration and enhanced agricultural productivity. Further, the small magnitude of SOC increases suggests a limited role for these Regenerative practices in climate change mitigation strategies in temperate regions.
Chemical exposures affect innate immune response to SARS-CoV-2
Authors: Arowolo Olatunbosun , Pobezinsky Leonid , Suvorov Alexander 
Published: November 2021

Abstract
Severe outcomes of COVID-19 are associated with pathological response of the immune system to the SARS-CoV-2 infection. Emerging evidence suggests that interaction may exist between COVID-19 pathogenesis and a broad range of xenobiotics, resulting in significant increases in death rates in highly exposed populations. Therefore, a better understanding of the molecular basis of the interaction between SARS-CoV-2 infection and chemical exposures may open opportunities for better preventive and therapeutic interventions. We attempted to gain mechanistic knowledge on the interaction between SARS-CoV-2 infection and chemical exposures using in-silico approach, where we identified genes and molecular pathways affected by both chemical exposures and SARS-CoV-2 in human immune cells (T-cells, B-cells, NK-cells, dendritic, and monocyte cells). Our findings demonstrate for the first time that overlapping molecular mechanisms affected by a broad range of chemical exposures and COVID-19 are linked to IFN type I/II signaling pathways and the process of antigen presentation. Based on our data, we also predict that exposures to various chemical compounds will predominantly impact the population of monocytes during the response against COVID-19.
Sleep Disturbances and Depressive and Anxiety Symptoms During Pregnancy: Associations With Delivery and Newborn Health
Authors: Peltonen Hilla Maaria , Paavonen Ella Juulia , Saarenpää-Heikkilä Outi , Vahlberg Tero , Paunio Tiina , Polo-Kantola Päivi 
Published: November 2021

Abstract
Background: Sleep disturbances and mood symptoms are common in late pregnancy and according to previous literature, they can affect delivery and newborn outcomes. This study evaluated the effect of sleep and mood symptoms on delivery and newborn health as there is insufficient and partly contradictory studies on the topic.Methods: A cohort of 1414 mothers was enrolled in the third trimester to this prospective cross-sectional questionnaire study. Validated questionnaires were assessed for measurement of sleep disturbances, depressive and anxiety symptoms. The data on delivery and newborn outcomes was obtained from hospital medical records.Results. Sleep disturbances were very common during pregnancy. Higher insomnia score (β = -0.06, p = 0.047) and longer sleep need (β = 0.07, p = 0.047) were related to delivery at a lower gestational age. In addition, higher insomnia score (β = -28.30, p = 0.010) and lower general sleep quality (β = -62.15, p = 0.025) were associated with lower birth weight, but instead, longer sleep duration and longer sleep need with higher birth weight (β = 28.06, p = 0.019; β = 27.61, p = 0.028, respectively). However, the findings regarding birth weight lost their significance when the birth weight was standardized with gestational weeks. Concerning Apgar scores and the umbilical artery pH, no associations were found. Snoring was associated with a shorter duration of the 1st phase (β = -78.71, p = 0.015) and total duration of delivery (β = -79.85, p = 0.016). Mothers with higher insomnia, depressive or anxiety symptoms were more often treated with oxytocin (OR 1.54 95% CI 1.00-2.38, p = 0.049, OR 1.76, 95% CI 1.02-3.04, p = 0.049 and OR 1.91, CI 95% 1.28-2.84, p < 0.001, respectively) and those with higher depressive and anxiety symptoms delivered more often with elective caesarean section (OR 4.67, 95% CI 2.04-12.68, p < 0.001 and OR 2.22, 95% CI 1.03-4.79, p = 0.042).Conclusions: Maternal sleep disturbances and mood symptoms during pregnancy are associated with delivery and newborn health. However, nearly all the outcomes fell within a normal range, implying that the actual risks are low.
Immunopreventable Diseases: Differences Between Genders in Brazil
Authors: Costa Élide Sbardellotto Mariano da , Hyeda Adriano , Maluf Eliane M C P 
Published: November 2021

Abstract
Immunopreventable diseases are a public health reality in Brazil and worldwide. The international literature defined that there is difference between sexes at the answer to the infectious diseases. Objective: to discriminate the hospitalizations associated with immunopreventable diseases in Brazil and their care costs, within the scope of the SUS, between 2008 and 2018, differentiating the data by gender. Methods: A population, observational, descriptive, retrospective study was conducted with secondary information from DATASUS. Results: A total of 457,479 hospitalizations were evaluated, totaling a direct cost of R$389,243,264.85, 53.17% in males and 46.83% in the female group (p-value 0.036). The trend analysis showed 6 diseases in decreasing situation (with statistical significance) and 4 in stationary tendency in the number of hospitalizations in the analyzed period. The direct costs of these hospitalizations were predominantly stationary for both sexes. Conclusions: the number of hospitalizations varied during the period analyzed, however the care costs of Immunopreventable diseases hospitalizations remained high, regardless of gender.
Use of Dantrolene and Ativan to Treat Overlapping Diagnosis NMS Versus Malignant Catatonia Case Report
Authors: Garcia-Baran Dynela , Collier Sam , Ortiz Alejandro 
Published: November 2021

Abstract
We present a case report of a patient who developed symptoms resembling malignant catatonia and neuroleptic malignant syndrome. Suspicion of neuroleptic malignant syndrome arose after treatment over his course of hospital stay with three different second-generation antipsychotics for a first-time bipolar type I manic episode. After a hospital stay of 5 days, the patient developed symptoms that could be interpreted as malignant catatonia or neuroleptic malignant syndrome. Administration of antipsychotics was immediately ceased, and the patient was transferred to the ICU where he was treated with dantrolene and higher dosages of Ativan. The patient improved after simultaneous intervention for both possible diagnoses. After approximately one month, quetiapine, one of the second generation antipsychotics previously prescribed, was restarted with good results and no reoccurrence of NMS or malignant catatonia. This case illustrates the potential dilemma faced when differentiation between the two obscure diagnoses is necessary. Diagnosis is typically established through clinical observation and monitoring of symptom evolution after the administration of neuroleptics. The treatment algorithms for each diagnosis vary as can the respective outcomes. Our case also highlights the dearth of research available on distinguishing neuropathologic psychiatric disorders from pathophysiologic psychomotor syndromes. It also focuses on the need for sound diagnostic scoring scales that will clarify the diagnostic picture as well as treatment guidelines to ensure best outcomes.
Changes in Objectively Measured Lifestyle Factors During the COVID-19 Pandemic in Community-Dwelling Older Adults
Authors: Ataka Takuya , Kimura Noriyuki , Eguchi Atsuko , Matsubara Etsuro 
Published: November 2021

Abstract
Background: In this manuscript, we aimed at investigating whether objectively measured lifestyle factors, including walking steps, sedentary time, amount of unforced physical activity, level of slight and energetic physical activity, conversation time, and sleep parameters altered before and during the COVID-19 pandemic among community-dwelling older adults.Methods: Data were obtained from a prospective cohort study conducted from 2015 to 2019 and a subsequent dementia prevention study undertaken in September 2020. Community-dwelling adults aged ≥65 years wore wearable sensors before and during the pandemic.Results: A total of 56 adults were enrolled in this study. The mean age was 74.2±3.9 years, and 58.9% (n=33) of the participants were female. The moderate and vigorous physical activity time significantly decreased and sedentary time significantly increased during the pandemic. Conclusions: This is the first study to demonstrate differences in objectively assessed lifestyle factors before and during the COVID-19 pandemic among community-dwelling older adults. The findings show that the pandemic has adversely affected physical activity among older adults living on their own in Japan.
Comparative Study of Outcomes by Surgical Procedures and Monocular Elevation Deficiency Syndrome in Indian Population
Authors: Shah Shreya , Shah Mehul A , Makhloga Shkshi , Korane Ashvini , Sanghani Meera 
Published: November 2021

Abstract
Introduction:Monocular elevation deficiency syndrome (MEDS) is a monocular elevation deficiency in abduction and adduction characterised by the hypofunction of superior rectus (SR) and inferior oblique muscles. Only a limited number of studies are published on the management of this problem. Herein, the indications and types of surgery for monocular elevation deficiency syndrome are reported.Methods: In this retrospective cohort study, all MEDS patients reported during 2010 to 2020 were retrieved from Electronic Medical Records after approval from the Hospital Ethical Committees. The data were exported in a pre-tested online format. The demographic and clinical information and data of surgeries, including strabismus and ptosis, were reported. The follow-up data were collected in a specific format. Strabismus was managed using Knapp procedure, Inferior Rectus recession and a combination of both approaches. Ptosis was corrected by Levator Palpebral Superioris (LPS) resection and brow suspension. The data were analysed using SPSS 22 based on descriptive analysis and cross-tabulation.Results: The cohort consists of 62 cases (females 26, males 36) of patients with mean age 17.00±12.31 years 40/62 cases comprised the paediatric age group. Knapp was carried out in 39, IR recession was carried out in 35, and combined Knapp+IR recession was performed in 17 cases based on FDT and FGT data. The comparative study found significant difference amongst these techniques (P=0.04). Ptosis correction was carried out by LPS resection in 21 and brow suspension in 23 cases depending on LPS function. This comparative study did not find any significant difference in the results (P=0.234).Conclusion: MEDS is a rare disease with various clinical features. The surgical management of strabismus may have more success for the combined technique than for those applied alone.
Potential Application of Fusarium Fungal Strains (Fusarium sp. FP, Arthrinium sp. FB and Phoma sp. FR) for Removal of Tl(I) Ions from Water
Authors: Mo Jianying , Liu Yonghui , Gao Xiaoning , Zhou Shuyi , Deng Yirong , Ke Yanyang , Peng Lihu , Li Huosheng , Chen Sihao , Long Jianyou 
Published: November 2021

Abstract
Water pollution caused by heavy metals poses a serious threat to the ecosystem and human survival safety and becomes a major obstacle to human health, economic and socially sustainable development. Among the various treatment techniques for water remediation, adsorption is an efficient method due to its high capacity, low cost, and simplicity. Thallium (Tl) is highly toxic to mammals and its removal from water is gaining increasingly prominent attention. In this study, three fungal strains (Fusarium sp. FP, Arthrinium sp. FB and Phoma sp. FR) were tested for removal of Tl(I) from an aqueous solution and showed excellent removal performance. The prepared inactive fungal strains were characterized by XRD, FT-IR, SEM, and XPS analysis. The effects of pH, contact time, biomass and reaction temperature on the removal efficiency of Tl(I) were systematically investigated. The results indicated that the adsorption isotherm data fit well with the Langmuir model, and the pseudo-second-order model was more consistent with the kinetic data description. The maximum adsorption capacity of the fungal strain (Fusarium sp. FP, Arthrinium sp. FB and Phoma sp. FR) for Tl(I) was found to be 94.69 mg/g, 66.97 mg/g and 52.98 mg/g, respectively. The thermodynamic data showed that the sorption process was spontaneous and endothermic. The present study showed that the inactive fungal strains could be a promising adsorbent material for Tl(I) removal.
Clean and Efficient Synthesis of High-Quality Silica From Rice Husk Ash
Authors: Baoyu Tang , Long Zhang , Zaiqian Yu 
Published: November 2021

Abstract
Rice husk ash derived from the rice husk, a renewable waste biomass resource from rice production can be used to produce high value-added silica materials with various applications. But present technologies suffer the shortages of using inorganic acid as the precipitating agent, complex salt-containing wastewater post-treatment, higher production cost, lower product quality, and without the recycling of process additives. In this paper, improved clean chemical precipitation characterizing of recycling the by-product and surfactant used is developed with the highest silica product yield of 99.3%, pore size (21-35 nm), and specific surface area (196-462 m2/g). After the by-product solution is reused 5 times, the yield of silica can still reach 99.1%. The recovery yield of surfactant is 95.3%. The properties of the prepared silica meet the standard of silica for specific applications. The process characterized the recycling of the by-product and surfactant in the process, greener CO2 precipitant, ensuring the greenness, process efficiency, and low production cost. This opens up a new industrialization practical way for up-grading utilization of waste biomass and CO2 containing industrial effluents.
High-Fat Diets Containing Different Types of Fatty Acids Modulate Gut-Brain Axis in Obese Mice
Authors: Hua Yinan , Shen Jingyi , Fan Rong , Xiao Rong , Ma Weiwei 
Published: November 2021

Abstract
Background: Excessive consumption of high-fat diets is associated with disordered metabolic responses, which may lead to chronic diseases. High-fat diets containing different types of fatty acids lead to distinct alterations in metabolic responses of gut-brain axis. Methods: In our study, normal male C57BL/6J mice were fed to multiple high fatty acid diets (long-chain and medium-chain saturated fatty acid, LCSFA and MCSFA group; n-3 and n-6 polyunsaturated fatty acid, n-3 and n-6 PUFA group; monounsaturated fatty acid, MUFA group; trans fatty acid, TFA group) and a basic diet (control, CON group) for 19 weeks. To investigate the effects of high-fat diets on metabolic responses of gut-brain axis in obese mice, blood lipids were detected by fast gas chromatography, and related proteins in brain and intestine were detected using Western blotting, ELISA, and immunochemistry analysis. Results: All high-fat diets regardless of their fatty acid composition induced obesity, lipid disorders, intestinal barrier dysfunction, and changes in gut-brain axis related factors except basal diet in mice. For example, the protein expression of zonula occludens-1 (ZO-1) in ileum in the n-3 PUFA group was higher than those in the MCSFA and CON group (all Ps < 0.05). The expressions of insulin in hippocampus and leptin in ileum in the MCSFA group were all higher than those in other groups (all Ps < 0.05). Conclusions: The high MCSFA diet had the most effect on metabolic disorders, and the high n-3 PUFA diet had the least effect on changes in metabolism.
Predictive Factors for Fatality After Traumatic Brain Injury Among Road Traffic Crash Victims in Addis Ababa City, Ethiopia
Authors: Mengistu Zuriyash , Ali Ahmed , Abegaz Teferi 
Published: November 2021

Abstract
Background
Traumatic brain injury (TBI) is one of the common preventable causes of mortality and disability among road traffic victims worldwide, most especially in low- and middle-income countries, including Ethiopia.
Objective
to determine risk factors of mortality after traumatic brain injury due to road traffic crash.
Methods
This study aimed to examine the predictive factors of short-term mortality after severe brain injury due to a road traffic crash. The study was done on a prospective cohort of 242 severely brain-injured patients selected using cluster sampling in Addis Ababa City hospitals. The study was conducted from February 2018 to November 2019. Data were collected from brain-injured patients using a questionnaire and recorded findings within the first 24 hours of admission, Survival Analysis was used for statistical analysis. Ethical clearance was obtained from the Addis Ababa University, College of Health Sciences Institutional Review Board (IRB). Confidentiality of information about injured patients was maintained.
Results
In this study, the death rate was 73(30.2%). The majority of TBI patients accounting for, 186(81%) were men. The median age of TBI patients was 29 years. The hazard for those patients with subnormal body temperature was 1.64 times that of normal temperature (AHR: 1.64; CI: 2.14-10.29). The estimated fatality hazard ratio for patients who experienced Glasgow Coma Scale (GCS)below six was 5.61 times higher compared to GCS six to eight (CI:3.1-10.24).
Conclusion
In conclusion, there was high early mortality of patients (30.2%) in Ethiopia. Being men, young and lower GCS were associated with higher mortality hazards. Hence, optimum advanced neuro-surgical pre-hospital care programs are urgently needed.