bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long life Perovskite Nanoplatelet Lasers with high quality factor enabled through engineering degradation pathways
Authors: Li Guohui , Pi Huihui , Wei Yanfu , Zhou Bolin , Gao Ya , Wen Rong , Hao Yuying , Zhang Han , Ong Beng S. , Cui Yanxia 
Published: December 2021

Abstract
MAPbI3 perovskite has attracted widespread interests for developing low-cost near infrared semiconductor gain media. However, it faces the instability issue under operation conditions, which remains a critical challenge. It is found that the instability of the MAPbI3 nanoplatelet laser comes from the thermal-induced-degradation progressing from the surface defects towards neighboring regions. By using PbI2 passivation, the defect-initiated degradation is significantly suppressed and the nanoplatelet degrades in a layer-by-layer way, enabling the MAPbI3 laser sustain for 4500 s (2.7×107 pulses), which is almost 3 times longer than that of the nanoplatelet laser without passivation. Meanwhile, the PbI2 passivated MAPbI3 nanoplatelet laser with the nanoplatelet cavity displaying a maximum quality factor up to ~7800, the highest reported for all MAPbI3 nanoplatelet cavities. Furthermore, a high stability MAPbI3 nanoplatelet laser that can last for 8500 s (5.1×107 pulses) is demonstrated based on a dual passivation strategy, by retarding the defect-initiated degradation and surface-initiated degradation, simultaneously. This work provides in-depth insights for understanding the operating degradation of perovskite lasers and the dual passivation strategy paves the way for developing high stability near infrared semiconductor laser media.
CENPU Promotes Growth and Metastasis in Nasopharyngeal Carcinoma by Inhibiting DUSP6
Authors: Lin Cheng , Zong Jingfeng , Xu Yun , Pan Jianji , Li Meifang , Lin Na 
Published: December 2021

Abstract
Background: Centromere protein U (CENPU), a centromere component, is key for mitosis and involved in the carcinogenesis of cancers. The role and mechanisms of CENPU in nasopharyngeal carcinoma (NPC) has not been described. Methods: CENPU expression in NPC cells and tissues was evaluated by RT-PCR and western blotting. Clinical significance of CENPU was evaluated by Immunohistochemistry. Biological functions of CENPU were evaluated by cell growth assay, colony formation assay, apoptosis assay, migration assay and invasion assays. Xenograft growth and lung metastasis model were conducted to investigate the effect of CENPU in vivo. Gene chip analysis, Ingenuity Pathway Analysis (IPA), and co-immunoprecipitation (Co-IP) experiments were used to explore the mechanisms of CENPU in NPC.Results: CENPU was highly expressed in NPC cells and samples. Patients with CENPU positive expression were closely associated with poor overall survival. Knockdown of CENPU inhibited proliferation and migration in vitro and in vivo in NPC. Gene chip analysis and IPA suggested that differentially expressed genes (DEGs) were significantly enriched in cancer and functions, including cellular movement, cellular development, cell growth and death, and proliferation when CENPU was downregulated. Dual specificity phosphatase 6 (DUSP6) was one of the DEGs and significantly decreased in NPC samples, and inversely correlated with expression with CENPU. Mechanism studies confirmed that CENPU increased the activation of ERK1/2 and p38 signal pathways by suppressing the expression of DUSP6. Therefore, our results suggested that CENPU might act as an oncogene in NPC and promote the development of NPC via inhibition of DUSP6, resulting in the inactivation of Erk1/2 and p38 pathways. Conclusions: CENPU facilitated cell proliferation and invasion by interacting with DUSP6. CENPU might be a promising prognostic biomarker and a potential target for NPC therapy.
Cooperative 3D Path Planning of Multi-UAV Via Improved Fruit Fly Optimization
Authors: Mao Yongjie , Huang Deqing , Qin Na , Zhu Lei , Zhao Jiaxi 
Published: December 2021

Abstract
Path planning of multiple unmanned aerial vehicles (UAVs) is a crucial step in cooperative operation of multiple UAVs, whose main difficulties lie in the severe coupling of time and three-Dimensional (3D) space as well as the complexity of multi-objective optimization. For this purpose, the time stamp segmentation (TSS) model is first adopted to resolve the timespace coupling among multiple UAVs. Meanwhile, the solution space is reduced by transforming the multiobjective problem to a multi-constraint problem. In consequence, based on the elite retention strategy, a novel improved fruit fly optimization algorithm (NIFOA) is proposed for multi-UAV cooperative path planning, which overcomes the shortcomings of basic fruit fly optimization algorithm in slow convergence speed and the potentials to fall into local optima. In particular, the multi-subpopulations evolution mechanism is further designed to optimize the elite subpopulation. At last, the effectiveness of the proposed NIFOA has been verified by numerical experiments.
Suicide and the Role of Educational Institutions: A 30-Year Systematic Review
Authors: Ramos Janaina Minelli de Oliveira , Dueñas Jorge-Manuel , Morales-Vives Fabia , Gallardo-Nieto Elena Maria 
Published: December 2021

Abstract
Suicide is the second leading cause of death in the 15–29 age group worldwide, and is a severe public health problem worldwide. Adolescent and young adult individuals primarily attend educational institutions which can play an essential role in detecting and preventing suicide. For this reason, the purpose of this research is to examine the role that educational institutions play in suicide prevention. A systematic review was conducted to determine what educational institutions and agents are identified in the literature when addressing suicide. The systematic review yielded 58 articles published over the last 30 years. The results show that a wide variety of educational stakeholders are required to intervene for suicide prevention between primary education and college. Overall, educational suicide initiatives report positive effects on participants’ understanding, attitudes, and beliefs regarding suicide and suicide prevention, although some studies have expressed some caution. The different types of programs and recommendations are discussed.
Effects of Biochar Application on Soil Nitrogen Conversion and Microbial Community Composition
Authors: Zhao Pingnan , Wang Shen , Liu Dong , Li Hongxu , Han Song , Li Ming 
Published: December 2021

Abstract
In northeastern China, successive years of cultivation have led to a decline in soil quality, a process that is exacerbated by the over-application of chemical fertilizers to ensure staple food production. The large amount of straw produced by cultivation is difficult to effectively use in recent years. There has been an increasing amount of research on the transforming straw into biomass char, but it has often focused on the effects of biomass char addition on soil physicochemical properties, without further exploring the mechanisms of this process and its effects on soil microorganisms. Microorganisms are an important part of the soil system and the process of how biomass char addition affects microorganisms through its effect on soil physicochemical properties should not be overlooked. In this study， the effect of biochar application at different preparation temperatures (300°C, 400°C and 500°C) and addition contents (0.1% and 1%) on ammonia, nitrate and total nitrogen in soil leachates were investigated. The effect of microbial sequencing on the dynamics of carbon and nitrogen was also investigated to reveal the mechanisms contributing to the changes in nitrogen forms. The results showed that biochar had a better adsorption ability on ammonia nitrogen, and biochar promoted the conversion of ammonia nitrogen to nitrate nitrogen by nitrifying bacteria. The addition of 1% biochar (prepared at 500°C) increased nitrate-nitrogen leaching by 86.52% compared to the control treatment. The sequencing of microorganisms also revealed that biochar changed the structure and abundance of the soil microbial community, especially increasing the relative abundance of the Helicobacter nitrification phylum by 2.02%. These results indicates that biochar facilitated the adsorption of ammonium nitrogen and the conversion of nitrate nitrogen, and solving the problem of low nitrogen fertilizer utilization while promoting the formation of beneficial bacteria in the soil.
The Effects of Greenness Exposure on Hypertension Incidence Among Chinese Oldest Old: A 10-Year Prospective Cohort Study
Authors: Wensu Zhou , Wenjuan Wang , Fenfen Zhou , Wen Chen , Ling Li 
Published: December 2021

Abstract
Background

Present studies showed greenness affected hypertension incidence. While population-based epidemiologic studies are limited in the oldest-old population (aged 80+).
Methods

This was a 10-year prospective cohort study that included oldest old (80 years +) from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Participants were free of hypertension at baseline (2008) and were followed up at 2011/2012, 2014, and 2018 waves. The 1-year average of the Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI) at 16-Day 500 m buffer before the year of hypertension event occurrence or last interview (for censoring) was estimated at 652 counties/districts units level of the participants resided and as exposure indicator. The non-linear association between greenness and hypertension incidence was performed by the Cox proportional hazards model with the penalized spline. The links between greenness and hypertension incidence were performed by the random-effects Cox proportional hazards model adjusted for potential confounding variables. We also examined the causal mediation effects of BMI, leisure activity, and PM2.5 on the association between greenness exposure and hypertension.
Results

Among 5432 participants, the incidence of hypertension was 7.25 (95% CI: 6.83 to 7.67) per 100 person-years. We found a non-liner association existed between greenness exposure and hypertension risk. In the fully adjusted model, the third tertile of NDVI value presenting protective effects on hypertension incidence compared with the first tertile (hazard ratios (HRs): 0.51; 95% confidence interval: 0.40-0.64). The third tertile of EVI value had a significant protective effect on hypertension incidence, compared with participants in the first tertile (HRs:0.44, 95%CI: 0.34-0.55). The effect of greenness exposure on hypertension was more pronounced in participants living in central/western China. We observed there were 41.63% and 17.01% of the association between NDVI/EVI exposure and hypertension was mediated by PM2.5, respectively.
Conclusions

Greenness could decrease approximate 50% risk induced by hypertension among oldest-old people, that is, expanding greenness is a recommended approach to hypertension prevention for the them. In particular, implementing plans to expanding green space construction in central/western China is needed. It is also emphasized the the importance of improve air quality when greenness exposure is existing.
The Influencing Factors of The Social Environment of Public Psychological Crisis In COVID-19
Authors: Tang Yaner , Kong Weiken , Pang Zhijian , Guan Shuwen 
Published: December 2021

Abstract
The COVID-19 epidemic spreads around the world early in 2020. As a public emergency, the COVID-19 epidemic has caused a public psychological crisis such as panic, anxiety and worry. Government trust and social support are considered social environmental factors affecting the public psychological crisis, but there is a lack of strong empirical evidence. Thus, it has important theoretical and practical significance to study the impact of government trust and social support on the public psychological crisis. Through regression analysis of the questionnaire during the pandemic, we found that government trust helps reduce public psychological crises, but informal social support increases public psychological crises. Therefore, strengthening government trust and preventing the negative effects of informal social support are effective ways to alleviate public psychological crises.
Salvianolic Acid B Activates Chondrocytes Autophagy and Reduces Chondrocyte Apoptosis in Obese Mice via the KCNQ1OT1/Mir-128-3p/SIRT1 Signaling Pathways
Authors: Sun Tianwen , Wang Fei , Hu Gaojian , Li Zhizhou 
Published: December 2021

Abstract
Purpose: Salvianolic acid B (Sal B) possesses strong anti-inflammatory and antioxidant activity. This study aims to explore the underlying mechanism of Sal B to improve the obesity-related osteoarthritis (OA). Methods: C57BL/6J male mice were fed with a standard diet, a high fat diet (HFD), or HFD with Sal B (25 mg/kg), and mouse body weights and osteoarticular inflammatory factor levels were examined. Mouse chondrogenic cell line ATDC5 were transfected with lncRNA KCNQ1 overlapping transcript 1 small hairpin RNA (KCNQ1OT1 shRNA), miR-128-3p mimic or Sirtuin-1 small interfering RNA (SIRT1 siRNA), then stimulated with Palmitic acid (PA) followed by the treatment of Sal B. Then, inflammatory response, apoptosis, and autophagy of ATDC5 cells in different groups were detected. Results: Sal B reduced body weight, decreased the levels of inflammatory markers, and improved cartilage damage in OA mice. KCNQ1OT1 was downregulated in OA mice and PA- stimulated ATDC5 cells. Sal B protected ATDC5 cells against PA-mediated inflammation, apoptosis, and the inhibition of autophagy, while knockdown of KCNQ1OT1 reversed these results. KCNQ1OT1 was found to be functioned as a ceRNA to bind and downregulate the expression of miR-128-3p that was upregulated in PA-induced cells. Furthermore, SIRT1 was verified as a target of miR-128-3p. MiR-128-3p overexpression reversed the effects of Sal B on inflammatory response, apoptosis, and autophagy in PA-stimulated cells, and knockdown of SIRT1 displayed similar results. Conclusion: Sal B exerted a chondroprotective effect by upregulating KCNQ1OT1, which indicates Sal B can used for a therapeutic agent in obesity-related OA.
A Simple Method To Repair A Supraglottic Airway Device
Authors: Wang Tingting , Wang Jiang , Lu Yao , Chen Shangui 
Published: December 2021

Abstract
Background: During the perioperative period or while in the intensive care unit, the inflation line is often cut accidentally during medical procedures or is damaged. As a result, it is not uncommon for a cuff leak to result in inadequate ventilation for the patient. The risk of using endotracheal tubes (ETTs) for secondary intubation is great, increasing the probability of respiratory tract infection and injury and even causing death in severe cases. The best method is to repair the damaged ETT to avoid secondary intubation and to ensure the safety of patients. Therefore, we recommend a practical and straightforward method to repair damage to the line or valve assembly of an endotracheal tube(ETT) and laryngeal mask airway (LMA).Methods: The distal end of a 22G vein (IV) catheter was inserted into the broken end of the inflation line. After insertion, the internal tube was withdrawn 1 mm to restore the inflation line. After 15 hours, the repaired ETT/LMA devices were tested for air leakage by measuring the pressure and load-bearing tension of the inflation line.Results: There was no difference in ETTs pressure between five intact ETTs and five repaired ETTs (Group A, ETT, mean difference = 0.2 cmH2O; 95% confidence interval 1.78 to 2.12 cmH2O; P = 0.82). When the cuff expanded to 120 cm H2O, there was no air leakage in the five ETTs after repair, and the tensile strength of the inflation line of the repaired ETTs in the experimental group was lower than that in the control group (each n = 5; mean difference = 33.3N; 95% confidence interval, 27.5 to 39.1N; P <0.001). There was no difference in LMAs pressure (Group B, LMAs, mean difference = 0.4 cmH2O; 95% confidence interval: -1.8 to −2.6 cmH2O; P = 0.67). When the cuff was expanded to 120 cmH2O, there was no air leakage from the five repaired LMAs. The tensile strength of the inflation line of the repaired LMAs in the experimental group was lower than that in the control group (n = 5; mean difference = −10; 95% confidence interval: −14 to −5.8 N; P = 0.001).Conclusion: When the ETT, LMA inflation line, or valve assembly is damaged or accidentally broken, an IV catheter can be directly inserted into the inflation line to quickly and effectively repair it. It is a safe and effective emergency remedial measure, which can be widely used in the clinic.
Flurochloridone Induced Abnormal Spermatogenesis by Damaging Testicular Sertoli Cells in Mice
Authors: Sun Weiqi , Tian Fang , Pan Hongjie , Chang Xiuli , Xia Minjie , Hu Jingying , Wang Yuzhu , Li Runsheng , Li Weihua , Yang Mingjun , Zhou Zhijun 
Published: December 2021

Abstract
BackgroundFlurochloridone (FLC), a selective herbicide used on a global scale, has been reported to have male reproductive toxicity which evidence is limited and the mechanism is still unclear. The present study was conducted to systematically explore the male reproductive toxicity of FLC, including sperm quality, spermatogenesis process, toxicity targets and possible mechanisms. MethodsMale C57BL/6 mice aged 6-7 weeks received gavage administration of FLC (365/730 mg/kg body weight) for 28 consecutive days. Then the tissue and sperm of mice were collected for analysis. We measured the coefficient of male reproductive organs, and analyzed sperm concentration, motility, malformation rate and mitochondrial membrane potential. Spermatocyte immunofluorescence staining was performed to analyze meiosis processes. At the same time, we performed pathological staining on the testis and epididymis tissue, and performed TUNEL staining, immunohistochemical analysis and ultrastructural observation on the testicular tissue.ResultsThe results showed that FLC caused mice testicular weight reduction, dysfunction and architectural damage, but no significant adverse effect was found in epididymis. The exposure interfered with the proliferation of spermatogonia and the process of meiosis, affecting sperm concentration, motility, kinematic parameters, morphology and mitochondrial membrane potential, leading to sperm quality decline. Furthermore, mitochondrial damage and apoptosis of testicular Sertoli cells were observed in mice treated with FLC. ConclusionWe found that FLC has significant adverse effects on spermatogonia proliferation and meiosis. Meanwhile, apoptosis and mitochondrial damage may be the potential mechanism of Sertoli cell damage. Our study demonstrated that FLC could induce testicular Sertoli cell damage, leading to abnormal spermatogenesis which resulted in sperm quality decline and provided a methodological reference for related studies.
The Biggest Megaraptoridae (Theropoda: Coelurosauria) of South America
Authors: Rolando Alexis M. Aranciaga , Motta Matias J. , Agnolín Federico L. , Manabe Makoto , Tsuihiji Takanobu , Novas Fernando E. 
Published: December 2021

Abstract
Megaraptorans are a theropod clade distributed in former Gondwana landmasses and Asia. Most members of the clade are known from early Cretaceous to Turonian times whereas Maastrichtian megaraptorans are known just from isolated and poorly informative remains. The aim of present contribution is to describe a partial skeleton of a megaraptorid coming from Maastrichtian beds at Santa Cruz province, Argentina. This new taxon constitutes the most informative megaraptoran from post-Turonian beds. Phylogenetic analysis nested the new taxon together with South American megaraptorans in a monophyletic clade, whereas Australian and Asian members constitute successive stem groups. South American forms differ from more basal megaraptorans in several anatomical features and in being much larger and more robustly built. It is possible that the Cenomanian-Turonian extinction of carcharodontosaurids was allowed to megaraptorans to occupy the niche of top predators in South America.
Separation Method of Semi-Fixed Variables Together with Dynamical System Method for Solving Nonlinear Time-Fractional PDEs with Higher-Order Terms
Authors: Rui Weiguo 
Published: December 2021

Abstract
It is well known that methods for solving fractional-order PDEs are grossly inadequate compared with integer-order PDEs. In this paper, a new approach which combined with the separation method of semi-fixed variables and dynamical system method is introduced. As example, a time-fractional reaction-diffusion equation with higher-order terms is studied under the different kinds of fractional-order differential operators. In different parametric regions, phase portraits of systems which derived from the reaction-diffusion equation are presented. Existence and dynamic properties of solutions of this nonlinear time-fractional models are investigated. In some special parametric conditions, some exact solutions of this time-fractional models are obtained. The dynamical properties of some exact solutions are discussed and the graphs of them are illustrated.PACS: 02.30.Jr; 02.30.Oz; 02.70.-c; 02.70.Mv; 02.90.+p; 04.20.Jb; 05.10.-a
Dynamics of Physical Autonomous Robotic Network With Constant And Time-Varying Communication Delays
Authors: Hsueh Kuei-Fang , Al-Darabsah Isam , Janaideh Mohammad Al , Campbell Sue Ann , Kundur Deepa 
Published: December 2021

Abstract
A Connected Autonomous Vehicle Network (CAVN) is an emerging paradigm that can reduce traffic congestion by allowing vehicles to cooperatively behave according to information out of the line of sight and improve traffic flow by decreasing inter-vehicular gaps on roadways. In this paper, the stability of CAVN with constant and time-varying communication delays is studied. When the time delay depends on time, the semi-discretization method is used to study the plant stability of the flow equilibrium of CAVN and construct approximate stability regions charts over control gain space. To study the influence of time-varying delay, a constant delay is considred as the average value of the time delay function. Then, explicit sufficient conditions are provided for the stability of the flow equilibrium and study the string stability of the CAVN. The proposed controller is validated using simulations and experimentally with a platoon of four autonomous robots under time-varying delays.