bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between human and AI influencers: parasocial relationships, credibility, and social capital formation in a collectivist market: a study of TikTok users in the Middle East
Authors: Omeish Fandi , Shaheen Ahmad , Alharthi Sager , Alfaiza Aisyah 
Published: February 2025

Abstract
In an era where social media influencers shape consumer attitudes and behaviors, the emergence of artificial intelligence (AI) influencers challenges traditional notions of authenticity and trust. This study explores whether AI influencers can cultivate parasocial relationships (PSRs) and credibility perceptions comparable to their human counterparts, and how these relationships translate into social capital within a culturally rich, collectivist setting. Drawing on Parasocial Interaction Theory, Source Credibility Theory, and Social Capital Theory, we examine TikTok users in Egypt and Jordan to determine how influencer type human or AI affects emotional engagement, perceived trustworthiness, and the formation of bonding and bridging social capital. Our findings reveal that AI influencers can indeed establish meaningful emotional bonds and credibility, sometimes outperforming human influencers in generating community cohesion and network expansion. Yet, these pathways differ, as human influencers rely more on narrative depth and cultural resonance to achieve similar outcomes. By integrating recently recommended studies and acknowledging alternative theoretical frameworks such as (S-O-R), we highlight the complexity and cultural specificity of influencer-follower interactions. This research not only advances our theoretical understanding of parasocial ties, credibility, and social capital but also provides actionable insights for marketers, brands, and platform developers. We conclude with methodological recommendations such as ensuring measurement invariance and conducting longitudinal, mixed-method research and emphasize the need to adapt influencer strategies to align with varying cultural orientations and rapidly evolving digital ecosystems.
Rapid Integration of LLMs in Healthcare Raises Ethical Concerns: An Investigation into Deceptive Patterns in Social Robots
Authors: Ranisch Robert , Haltaufderheide Joschka 
Published: February 2025

Abstract
Conversational agents are increasingly used in healthcare, with Large Language Models (LLMs) significantly enhancing their capabilities. When integrated into social robots, LLMs offer the potential for more natural interactions. However, while LLMs promise numerous benefits, they also raise critical ethical concerns, particularly regarding hallucinations and deceptive patterns. In this case study, we observed a critical pattern of deceptive behavior in commercially available LLM-based care software integrated into robots. The LLM-equipped robot falsely claimed to have medication reminder functionalities, not only assuring users of its ability to manage medication schedules but also proactively suggesting this capability despite lacking it. This deceptive behavior poses significant risks in healthcare environments, where reliability is paramount. Our findings highlights the ethical and safety concerns surrounding the deployment of LLM-integrated robots in healthcare, emphasizing the need for oversight to prevent potentially harmful consequences for vulnerable populations.
Analysis of National Cybersecurity Strategies of G20: objectives, latent themes, latest trends and comparisons
Authors: Çifci Hasan , Ergüner Esma 
Published: February 2025

Abstract
This study analyzes National Cyber Security Strategies (NCSSs) of G20 countries through a novel combination of qualitative and quantitative methodologies. It focuses on delineating the shared objectives, distinct priorities, latent themes, and key priorities within the NCSSs. Latent dirichlet allocation topic modeling technique was used to identify implicit themes in the NCSSs to augment the explicitly articulated strategies. By exploring the latest versions of NCSS documents, the research uncovers a detailed panorama of multinational cybersecurity dynamics, offering insights into the complexities of shared and unique national cybersecurity challenges. Although challenged by the translation of non-English documents and the intrinsic limitations of topic modeling, the study significantly contributes to the cybersecurity policy domain, suggesting directions for future research to broaden the analytical scope and incorporate more diverse national contexts. In essence, this research underscores the indispensability of a multifaceted, analytical approach in understanding and devising NCSSs, vital for navigating the complex, and ever-changing digital threat environment.
Non-perturbative reducibility of three-dimensional skew symmetric systems without any non-degeneracy condition
Authors: ZHANG DONGFENG , XU JUNXIANG 
Published: February 2025

Abstract
We consider the system

$\dot {x}=(A+ P(t,\epsilon )) x, x\in \mathbb {R}^{3}, $

where

$A, P$

are both three-dimensional skew symmetric matrices, A is a constant matrix with eigenvalues

$\pm i\unicode{x3bb} $

and 0,

$P(t,\epsilon )$

is

$C^{m}(m=0,1)$

-smooth in

$\epsilon $

and analytic quasi-periodic with respect to t with basic frequencies

$\omega =(1,\alpha )$

, with

$\alpha $

being irrational, and

$\epsilon $

is a small parameter. Under some non-resonant conditions about the basic frequencies and the eigenvalues of the constant matrix and without any non-degeneracy condition, it is proved that for many sufficiently small parameters, this system can be reduced to a rotation system. Furthermore, if the basic frequencies satisfy that

$ 0\leq \beta (\alpha ) < r,$

where

$\beta (\alpha )=\limsup \nolimits _{n\rightarrow \infty } {\ln q_{n+1}}/{q_{n}},$

$q_{n}$

is the sequence of denominations of the best rational approximations for

$\alpha \in \mathbb {R} \setminus \mathbb {Q},$

r is the initial radius of analytic domain, it is proved that for many sufficiently small parameters, this system can be reduced to a constant system.
Angel Unaware, Cognitive Disability, and the Politics of Positive Thinking
Authors: Walker-Cornetta Andrew 
Published: February 2025

abstractThis article focuses on what may very well be the most popular text about cognitive disability in US American history. Released in 1953, Angel Unaware told the story of Hollywood stars Dale Evans’ and Roy Rogers’s experiences raising a young daughter who had been diagnosed at birth with what her mother referred to as an “appalling handicap” (what would later be labeled Down Syndrome). Situating this work and its reception within existing scholarship on postwar religion in the United States, this essay offers a novel interpretation of positive-thinking Christianity by showing how its grammars inspired and underwrote a nascent politics of disability for parents of “exceptional” children and their allies. In doing so, it not only underscores how religion has shaped notions of human difference in US American culture but also identifies disability as a crucial and heretofore neglected site of American religion making.
NARRATIVE AND CLOSURE IN FRONTO’S EPISTVLAE AD MARCVM CAESAREM ET INVICEM BOOK 5
Authors: Anastasi Mary K. 
Published: February 2025

Abstract
This paper argues that the unknown editor of Ad M. Caesarem et inuicem arranged the letters in their non-chronological order so as to create a work that is essentially historical fiction, providing the reader with a romanticized version of the early life of Marcus Aurelius, a Marcopaedia of sorts or even a quasi-prequel to the Meditations. The paper demonstrates that the anomalous Book 5—full of shorter, less elaborate letters—can be read not only as an appendix composed of leftover letters but also as a part of the broader narrative. Book 5 creates a sense of closure to the epistolary fiction created by the editor. In particular, this article focusses on the recurrent motif of Fronto’s health; the frequent references to Fronto’s illness work in a metaliterary fashion to signal the impending conclusion of the work, creating a sense of resolution for the health/sickness letters appearing in Books 1–4. The sickness/health topic also connects to certain philosophical topoi regarding death, illness and consolation—a connection that is appropriate in light of the young Marcus’ burgeoning interest in philosophy.
TRUTH, TRUTHFULNESS AND THE BEGINNINGS OF ANCIENT GREEK HISTORIOGRAPHY: A CRITICAL RESPONSE TO BERNARD WILLIAMS
Authors: Kindt Julia 
Published: February 2025

abstract
This article offers a critical evaluation of Bernard Williams’s influential account of ancient Greek historiography and the place of ancient Greek thought in the early history of ideas in his last book Truth and Truthfulness: An Essay in Genealogy (Princeton, 2002). It argues that such an evaluation is warranted now not only because Williams’s stance continues to influence how Herodotus and Thucydides are viewed by scholars outside of classical studies; more importantly, it also opens up the field of classical studies itself to a much needed engagement with those ideas from Williams’s influential study that can be productively applied to the study of Herodotus and Thucydides.
The first part consists of a critical appraisal of Williams’s views in light of current classical scholarship on early Greek historiography. The second part makes the case for why Herodotus rather than Thucydides would have served as the better example for Williams to explore the historical conditions and intellectual milieu that led to the emergence of truth and truthfulness as a problem in the Western historiographic tradition. Drawing on recent classical scholarship, the article shows that it was Herodotus, rather than Thucydides, who first conceived of the truth as a problem; that it was him rather than Thucydides who first grappled with sincerity and accuracy as the values that Williams identifies as fundamental to the truth-claims embedded in the historiographic tradition.
The article thus suggests that the history of truthfulness as a relational concept that binds together author and audience in a mutual contract of trust should start with him rather than Thucydides. It shows how Williams’s account of truth as a social value that binds author and audience together in a mutual contract of trust can be productively applied to the study of Herodotus’ Histories. A conclusion focuses on the role that has typically been attributed to the ancient world in genealogical accounts of the history of ideas.
Collateral damage of the energy transition? Investigating the avoidance of powerlines by the Eurasian Skylark Alauda arvensis in a German agricultural landscape
Authors: Klaus Sebastian , Liew Jia Huan , Müller Christian , Jechow Boris 
Published: February 2025

Summary
We investigated Eurasian Skylark Alauda arvensis avoidance of powerlines and their pylons by assessing the spatial distribution of Skylark territories. We mapped territory centres in a central German agricultural landscape during 2020 and used Bayesian logistic regression models to test if distances from powerlines and pylons are predictive of the presence of territories. We also tested other possible predictors, namely, nearest distances from roads, vertical structures, wind energy plants, settlements, as well as the nearest pylon type and vegetation. Distances from the nearest road and settlement were positively correlated with the probability of territory occurrence. However, distance from powerlines and pylons were not significant predictors. Skylarks were also more likely to establish territories in areas where winter grain is present. We conclude that powerlines are unlikely to lead to significant habitat reduction for the Skylark that would impact local populations. We can, however, confirm avoidance behaviour towards roads and settlements, as well as a preference for areas with winter grain because the crop’s growth period coincides with the start of the breeding season, initially providing vegetation of a suitable height and coverage.
CONFORMAL IMAGE REGISTRATION USING THE DISCRETIZED CAUCHY–RIEMANN EQUATIONS
Authors: TUFAIL M. Y. , GUL S. 
Published: February 2025

Abstract
Conformal image registration has always been an area of interest among modern researchers, particularly in the field of medical imaging. The idea of image registration is not new. In fact, it was coined nearly 100 years ago by the pioneer D’Arcy Wentworth Thompson, who conjectured the idea of image registration among the biological forms. According to him, several images of different species are related by a conformal transformations. Thompson’s examples motivated us to explore his claim using image registration. In this paper, we present a conformal image registration (for the two-dimensional grey scaled images) along with a penalty term. This penalty term, which is based on the Cauchy–Riemann equations, aims to enforce the conformality.
Spanish Validation of the Maastricht Acute Stress Test (MAST): A Cost-effective Stress Induction Protocol
Authors: Santos-Carrasco Daniel , De La Casa Luis Gonzalo 
Published: February 2025

Abstract
The rise of stress studies has led to the existence of multiple stress induction protocols. However, cultural differences in stress reactivity are often overlooked. Therefore, this study aims to validate the Maastricht Acute Stress Test (MAST) in the Spanish population. A sample of 96 young adult participants was divided into an experimental group and a control group based on whether they were exposed to the MAST or a non-stressful control task. State anxiety and positive and negative affects were measured before and immediately after the protocol, while physiological stress (blood pressure and heart rate) was monitored throughout the experiment. The experimental group exhibited an increase in state anxiety, negative affect, and systolic and diastolic blood pressures after the MAST protocol. Participants with higher psychopathological risk presented higher scores of psychological stress than those with lower risk. Finally, it was found that participants with higher mathematical performance exhibited lower anxious reactivity following stressor exposure. Our results confirm the efficacy of the MAST and its validation for use in the Spanish population.
Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice
Authors: Chen Si , Lee Yu-Bin , Song Mi-Young , Lim Changjin , Cho Hwangeui , Shim Hyun Joo , Kim Jong-Suk , Park Byung-Hyun , Kim Jeon-Kyung , Bae Eun Ju 
Published: February 2025

Abstract
Cannabidiol (CBD), a nonpsychoactive compound from Cannabis, has various bioactive functions in humans and animals. Evidence suggests that CBD promotes muscle injury recovery in athletes, but whether and how CBD improves endurance performance remains unclear. Here we investigated the effects of CBD treatment on exercise performance in mice and assessed whether this effect involves the gut microbiome. CBD administration significantly increased treadmill running performance in mice, accompanied by an increase in oxidative myofiber composition. CBD also increased mitochondrial biogenesis and the expression of associated genes such as PGC-1α, phosphorylated CREB and AMPK in muscle tissue. Interestingly, CBD altered the composition of the gut microbiome, and antibiotic treatment reduced the muscle endurance-enhancing effects of CBD and mitochondrial biogenesis. We isolated Bifidobacterium animalis, a microbe increased by CBD administration, and named it KBP-1. Treatment with B. animalis KBP-1 in mice resulted in improved running performance. Whole-genome analysis revealed that B. animalis KBP-1 presented high expression of genes involved in branched-chain amino acid biosynthesis, expression of branched-chain amino acid release pumps and metabolism of lactic acid. In summary, our study identified CBD and B. animalis KBP-1 as potential endurance exercise-promoting agents.
A humanized NOVA1 splicing factor alters mouse vocal communications
Authors: Tajima Yoko , Vargas César D. M. , Ito Keiichi , Wang Wei , Luo Ji-Dung , Xing Jiawei , Kuru Nurdan , Machado Luiz Carlos , Siepel Adam , Carroll Thomas S. , Jarvis Erich D. , Darnell Robert B. 
Published: February 2025

Abstract
NOVA1, a neuronal RNA-binding protein expressed in the central nervous system, is essential for survival in mice and normal development in humans. A single amino acid change (I197V) in NOVA1’s second RNA binding domain is unique to modern humans. To study its physiological effects, we generated mice carrying the human-specific I197V variant (Nova1

hu/hu
) and analyzed the molecular and behavioral consequences. While the I197V substitution had minimal impact on NOVA1’s RNA binding capacity, it led to specific effects on alternative splicing, and CLIP revealed multiple binding peaks in mouse brain transcripts involved in vocalization. These molecular findings were associated with behavioral differences in vocalization patterns in Nova1

hu/hu
mice as pups and adults. Our findings suggest that this human-specific NOVA1 substitution may have been part of an ancient evolutionary selective sweep in a common ancestral population of Homo sapiens, possibly contributing to the development of spoken language through differential RNA regulation during brain development.
Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis
Authors: Modenbach Jana Marielle , Möller Christina , Asgarbeik Saeedeh , Geist Norman , Rimkus Niklas , Dörr Mark , Wolfgramm Hannes , Steil Leif , Susemihl Anne , Graf Leonie , Schmöker Ole , Böttcher Dominique , Hammer Elke , Glaubitz Juliane , Lammers Michael , Delcea Mihaela , Völker Uwe , Aghdassi Ali Alexander , Lerch Markus M. , Weiss Frank Ulrich , Bornscheuer Uwe T. , Sendler Matthias 
Published: February 2025

Abstract
Acute pancreatitis (AP) is characterised by self-digestion of the pancreas by its own proteases. This pathophysiological initiating event in AP occurs inside pancreatic acinar cells where intrapancreatic trypsinogen becomes prematurely activated by cathepsin B (CTSB), and induces the digestive protease cascade, while cathepsin L (CTSL) degrades trypsin and trypsinogen and therefore prevents the development of AP. These proteases are located in the secretory compartment of acinar cells together with cystatin C (CST3), an endogenous inhibitor of CTSB and CTSL. The results are based on detailed biochemical analysis, site-directed mutagenesis and molecular dynamics simulations in combination with an experimental disease model of AP using CST3 deficient mice. This identifies that CST3 is a critical regulator of CTSB and CTSL activity during AP. CST3 deficient mice show a higher intracellular CTSB activity resulting in elevated trypsinogen activation accompanied by an increased disease severity. This reveals that CST3 can be cleaved by trypsin disabling the inhibition of CTSB, but not of CTSL. Furthermore, dimerised CST3 enhances the CTSB activity by binding to an allosteric pocket specific to the CTSB structure. CST3 shifts from an inhibitor to an activator of CTSB and therefore fuels the intrapancreatic protease cascade during the onset of AP.
The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro
Authors: Yang Qingran , Guo Haoran , Li Huili , Li Zhaoxue , Ni Fushun , Wen Zhongmei , Liu Kai , Kong Huihui , Wei Wei 
Published: February 2025

Abstract
Respiratory viruses pose an ongoing threat to human health with excessive cytokine secretion contributing to severe illness and mortality. However, the relationship between cytokine secretion and viral infection remains poorly understood. Here we elucidate the role of CXCL8 as an early response gene to EV-D68 infection. Silencing CXCL8 or its receptors, CXCR1/2, impedes EV-D68 replication in vitro. Upon recognition of CXCL8 by CXCR1/2, the MAPK pathway is activated, facilitating the translocation of nuclear hnRNP-K to the cytoplasm. This translocation increases the recognition of viral RNA by hnRNP-K in the cytoplasm, promoting the function of the 5′ untranslated region in the viral genome. Moreover, our investigations also reveal the importance of the CXCL8 signaling pathway in the replication of both influenza virus and rhinovirus. In summary, our findings hint that these viruses exploit the CXCL8/MAPK/hnRNP-K axis to enhance viral replication in respiratory cells in vitro.
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness
Authors: Moghe Prachiti , Belousov Roman , Ichikawa Takafumi , Iwatani Chizuru , Tsukiyama Tomoyuki , Erzberger Anna , Hiiragi Takashi 
Published: February 2025

Abstract
Tissue patterning coordinates morphogenesis, cell dynamics and fate specification. Understanding how precision in patterning is robustly achieved despite inherent developmental variability during mammalian embryogenesis remains a challenge. Here, based on cell dynamics quantification and simulation, we show how salt-and-pepper epiblast and primitive endoderm (PrE) cells pattern the inner cell mass of mouse blastocysts. Coupling cell fate and dynamics, PrE cells form apical polarity-dependent actin protrusions required for RAC1-dependent migration towards the surface of the fluid cavity, where PrE cells are trapped due to decreased tension. Concomitantly, PrE cells deposit an extracellular matrix gradient, presumably breaking the tissue-level symmetry and collectively guiding their own migration. Tissue size perturbations of mouse embryos and their comparison with monkey and human blastocysts further demonstrate that the fixed proportion of PrE/epiblast cells is optimal with respect to embryo size and tissue geometry and, despite variability, ensures patterning robustness during early mammalian development.
Archaean green-light environments drove the evolution of cyanobacteria’s light-harvesting system
Authors: Matsuo Taro , Ito-Miwa Kumiko , Hoshino Yosuke , Fujii Yuri I. , Kanno Satomi , Fujimoto Kazuhiro J. , Tsuji Rio , Takeda Shinnosuke , Onami Chieko , Arai Chihiro , Yoshiyama Yoko , Mino Yoshihisa , Kato Yuki , Yanai Takeshi , Fujita Yuichi , Masuda Shinji , Kakegawa Takeshi , Miyashita Hideaki 
Published: February 2025

Abstract
Cyanobacteria induced the great oxidation event around 2.4 billion years ago, probably triggering the rise in aerobic biodiversity. While chlorophylls are universal pigments used by all phototrophic organisms, cyanobacteria use additional pigments called phycobilins for their light-harvesting antennas—phycobilisomes—to absorb light energy at complementary wavelengths to chlorophylls. Nonetheless, an enigma persists: why did cyanobacteria need phycobilisomes? Here, we demonstrate through numerical simulations that the underwater light spectrum during the Archaean era was probably predominantly green owing to oxidized Fe(III) precipitation. The green-light environments, probably shaped by photosynthetic organisms, may have directed their own photosynthetic evolution. Genetic engineering of extant cyanobacteria, simulating past natural selection, suggests that cyanobacteria that acquired a green-specialized phycobilin called phycoerythrobilin could have flourished under green-light environments. Phylogenetic analyses indicate that the common ancestor of modern cyanobacteria embraced all key components of phycobilisomes to establish an intricate energy transfer mechanism towards chlorophylls using green light and thus gained strong selective advantage under green-light conditions. Our findings highlight the co-evolutionary relationship between oxygenic phototrophs and light environments that defined the aquatic landscape of the Archaean Earth and envision the green colour as a sign of the distinct evolutionary stage of inhabited planets.