bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ca2+ signal contributing to jasmonic acid‐induced direct and indirect defense against the whitefly Bemisia tabaci in tomato plants
Authors: Liu Xin , Hussain Sabir , Xie Wen , Guo Zhaojiang , Wu Qingjun , Wang Shaoli , Liu Yong , Zhang Youjun 
Published: July 2021

AbstractThe phytophagous whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) causes serious crop yield losses around the world especially by vectoring viruses. Exogenous jasmonic acid (JA) induces direct plant resistance to B. tabaci, but the underlying mechanism of JA‐induced exogenous defenses is not well understood. Here, we demonstrate that exogenous JA not only increases the cytosolic Ca2+ concentration ([Ca2+]cyt) in tomato mesophyll cells but also induces the expression of Ca2+‐sensor genes and plant defense genes. Pre‐treatment with Ca2+ inhibitor (ruthenium red) significantly repressed the elevation of [Ca2+]cyt, expression of JA‐induced genes, and emission of plant volatiles induced by JA, thus reducing the JA‐induced direct (feeding choice and fitness of B. tabaci) and indirect [olfactory choice and parasitism by the parasitoid Encarsia formosa Gahan (Hymenoptera: Aphelinidae)] plant resistance to B. tabaci. These results indicate that the Ca2+ signal induced by JA mediates and directs the plants defenses against whitefly. Present results will not only give us a better understanding of how exogenous JA influences the crop community, but also deliver some clues for the potential application of exogenous JA, as a plant elicitor, in whitefly management.
Entomopathogenicity of fungi in combination with Ricinus communis extract for the control of Aleurocanthus woglumi
Authors: Barbosa Luiz Felipe Silva , Santos Ana Carla da Silva , Diniz Athaline Gonçalves , Alves Amanda Lucia , de Oliveira Antonio Fernando Morais , da Costa Antonio Félix , Tiago Patricia Vieira 
Published: July 2021

AbstractCitrus is among the most important crops in the world, and has suffered losses of up to 80% due to the citrus blackfly, Aleurocanthus woglumi Ashby (Hemiptera: Aleyrodidae). The combined use of entomopathogenic fungi and plant extracts is a sustainable alternative to control this pest. The objectives of this study were to select entomopathogenic fungi to control A. woglumi and verify the insecticidal effect of the combined use of the selected fungi and aqueous extracts of castor bean leaves, Ricinus communis L. (Euphorbiaceae). Twenty fungal isolates obtained from field‐collected dead A. woglumi were identified and tested against the insect. Eight were identified as belonging to Fusarium incarnatum‐equiseti species complex, nine to Fusarium fujikuroi species complex, two to Cordyceps javanica (Bally) Kepler, B. Shrestha & Spatafora, and one to genus Akanthomyces. The five isolates that caused the maximum confirmed mortality were tested for compatibility with aqueous castor bean extract at 5, 10, and 20% (wt/vol) concentrations. Qualitative phytochemical analysis showed the presence of alkaloids, glycoside flavonoids, saponins, and tannins in the castor bean extract. Most of the isolates studied caused high confirmed mortality of citrus blackfly. In the compatibility tests, Fusarium volatile Al‐Hatmi, Sand.‐Den., SA Ahmed & de Hoog and Fusarium proliferatum (Matsush.) Nirenberg ex Gerlach & Nirenberg combined with the 5% aqueous extract were the most suitable for testing against A. woglumi. Additive interactions were observed for the combined control agents. The highest value of confirmed mortality (98.2%) was observed for the combination of 5% aqueous castor bean extract and F. volatile (URM 8051), the efficacy of which should be confirmed by field tests.
Family adjustment to COVID‐19 lockdown in Italy: Parental stress, coparenting, and child externalizing behavior
Authors: Giannotti Michele , Mazzoni Noemi , Bentenuto Arianna , Venuti Paola , de Falco Simona 
Published: July 2021

AbstractEvidence of psychological distress in families during COVID‐19 outbreak are arising. However, the perceived changes in psychological adjustment during home confinement with respect to the period before the pandemic have not been addressed yet. Moreover, little is known about the role of coparenting and specific COVID‐19 contextual variables on parental stress and children's behavioral difficulties in the Italian context. Using a cross‐sectional survey, we collected data on 841 Italian parents of children aged 3–11 years with typical development during the home confinement (20th April–18th May). We analyzed levels of parental stress, coparenting, and child externalizing behaviors before and during the home confinement. Additionally, hierarchical regressions were performed to investigate predictors of parental stress and child externalizing behaviors during the lockdown. Results showed that parental stress (especially in mothers) and child externalizing behaviors increased during the lockdown period. Coparenting was a strong predictor of parental stress, together with being a mother, younger child age, less time dedicated to the child, and scarce feasibility of remote working. Besides, child externalizing behaviors were predicted by male gender, less parental time dedicated to the child, higher parental stress, and child distance learning workload. Our findings indicate a negative impact of COVID‐19 lockdown in both parents and children, suggesting that positive coparenting and time dedicated to children may help to reduce the detrimental effect of pandemic restrictions on family adjustment.
Determination of problems experienced during the COVID‐19 pandemic by individuals receiving hemodialysis treatment
Authors: Bulbul Elif , Dogan Pinar , Sendir Merdiye , Kaya Abdulsamed , Ozdemir Cevriye 
Published: July 2021

AbstractBackgroundPatients receiving hemodialysis treatment are among the risk groups during the COVID‐19 pandemic. They must cope with many factors simultaneously like anxiety about being ill, social isolation, inadequate information about protective precautions, and the need to attend regular treatment.ObjectivesThis study was performed with the aim of determining problems experienced by individuals receiving hemodialysis treatment during the pandemic.DesignThis was a descriptive and cross‐sectional type study.ParticipantsThe research included 234 patients receiving chronic hemodialysis treatment.MeasurementsFor collection of data in the research, a patient descriptive information form and COVID‐19 phobia scale (CP19‐S) scale were used.ResultsPatients receiving hemodialysis treatment were determined to have high levels of compliance with individual precautions required during the pandemic. Of patients, 87.6% were determined to experience concern about bringing infection from the dialysis unit to family members. The mean total points for CP19‐S were 59.80 ± 14.49. Patients who were female, had low educational level, were not employed, had heart disease in addition to kidney failure, with hemodialysis age from 6 to 8 years, who did not want to go to the dialysis center and had not received education about the pandemic (p < 0.001) were identified to have high phobia at statistically significant levels.ConclusionsChanges occurring in normal life and to hemodialysis treatment during the pandemic cause concern and anxiety in many patients. In this process, providing patients with education about the pandemic and protective methods is very important.
Five decades of the International Endodontic Journal: Bibliometric overview 1967–2020
Authors: Khan Abdul S. , Ur Rehman Shafiq , Ahmad Shakil , AlMaimouni Yara K. , Alzamil Manar A. S. , Dummer Paul M. H. 
Published: July 2021

AbstractAimThe International Endodontic Journal (IEJ) has served as a platform for research and clinical practice in Endodontics since 1967. This study provides a bibliographic analysis and overview of the publications that have appeared in the IEJ from 1967 to 2020.MethodologyA literature search was performed in Elsevier's Scopus database to locate all the publications of the International Endodontic Journal. Various bibliometric software packages including the open‐source visualization software Gephi and Biblioshiny (version 2.0) were employed for data visualization and analysis.ResultsA total of 3739 records with citation and bibliographic details were selected and retrieved to allow a bibliometric analysis to be performed. The bibliometric analysis indicates that the IEJ has grown both in terms of productivity and influence. Over time, the journal has been associated with an increase in the number of manuscripts published and the citations they have attracted, but with minor downward fluctuations in citations in the last few years. Bibliographic coupling of the IEJ articles revealed that the major research themes published in the journal include ‘endodontics’, ‘root canal treatment’, ‘calcium hydroxide’, ‘apical periodontitis’, ‘mineral trioxide aggregate’, ‘microbiology’, ‘cyclic fatigue’, ‘cone‐beam computed tomography’ and ‘micro‐computed tomography’. Authors affiliated to institutions in the UK were the major contributors to the journal and were linked with other countries such as Brazil, USA and Malaysia. The largest number of publications were from the University of São Paulo, Brazil.ConclusionThe IEJ is one of the leading journals in Endodontology and has been providing a platform for innovative research and clinical reports for more than 50 years. Publications have been associated with a wide range of authors, institutions and countries around the world.
Public justifications for the US minimum wage
Authors: Benton Mark 
Published: July 2021

AbstractThis research draws on four macroeconomic approaches to examine survey data, in order to understand how the US public justifies their positions on the US minimum wage. Using data collected from the 2018 Cooperative Congressional Election Study, survey responses are coded to understand the public's justifications for minimum wage in the United States. Findings show that respondents had myriad justifications for the minimum wage beyond economic justifications. Moreover, the justifications that people use to support their minimum wage positions seem to be more patterned with political than economic variables. Discussions about the minimum wage in the United States have tended to prioritise the minimum wage's effects on economic variables, but more recent theories consider the social and political implications of minimum wage policies. Policymakers and scholars should keep the political and social character of the minimum wage in the United States in mind, especially during contemporary rare moments of political institutional unity that allow for major shifts in minimum wage policy.
Hollow mesoporous silica capsules loaded with copper, silver, and zinc oxide nanoclusters for sustained antibacterial efficacy
Authors: Krakor Eva , Saniternik Sven , Gessner Isabel , Frohnhoven Robert , Wilhelm Michael , Drexelius Marco , Tosun Nurgül , Neundorf Ines , Mathur Sanjay 
Published: July 2021

AbstractIntensive and overuse of antibiotics during the last years has triggered a distinct rise in antibiotic resistance worldwide. In addition to the newly developed antimicrobials, there is a high demand for alternative treatment options against persistent bacterial infections. The biocidal impact of metal ions like copper (Cu2+), silver (Ag+), and zinc (Zn2+), also known as the oligodynamic effect has been used for ages to kill or inhibit the growth of microorganisms and to employ long‐term prevention strategies against their biological antagonists. Herein, we report on the synthesis of Cu, Ag, and Zn metal and corresponding oxide nanoparticles immobilized on hollow mesoporous silica capsules (HMSCs) obtained by a hard‐template assisted sol‐gel synthesis followed by reduction of appropriate metal salts in the presence of HMSCs. Compartmentalization of nanosized metal and oxide clusters in Ag@HMSCs, Cu@HMSCs, and ZnO@HMSCs particles prevented their agglomeration and offered high release kinetics of metal ions between 2.0 and 3.7 mM during 24 h, as monitored by UV‐vis analyses. The distribution and morphology of pristine and metal functionalized HMSCs were evaluated by transmission electron microscopy analysis revealing the successful synthesis of Ag, Cu, and ZnO nanoparticles supported on HMSCs. X‐ray photoelectron spectroscopy revealed that mainly Cu(II), Ag(0), and Zn(II) species were present in the modified HMSCs. In addition to the surface attachment of preformed metal (Ag and Cu) and metal oxide (ZnO) cluster, nucleation of metal nanoparticles inside the void of HMSCs provided an internal reservoir which allowed for a time‐dependent release of metal ions through slower dissolution rates leading to a long‐term and sustained bacterial inhibition over several hours. The high antimicrobial efficiency of Ag@HMSCs, Cu@HMSCs, and ZnO@HMSCs particles was investigated toward both Gram‐positive (Bacillus subtilis) and Gram‐negative (Escherichia coli) bacteria by INT assays showing a complete growth inhibition for both bacteria types after 24 h. While Ag@HMSCs and Cu@HMSCs showed a higher susceptibility against Gram‐negative bacteria, ZnO@HMSCs showed a higher susceptibility against Gram‐positive bacteria. This demonstrates the promise of metal‐loaded capsules as antibacterial delivery vehicles with dual‐mode time‐release profiles being potential alternatives for antibiotic drugs.
Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post‐ischaemic inflammatory response
Authors: Pluijmert Niek J. , de Jong Rob C. M. , de Vries Margreet R. , Pettersson Knut , Atsma Douwe E. , Jukema J. Wouter , Quax Paul H. A. 
Published: July 2021

AbstractPhosphorylcholine is a pro‐inflammatory epitope exposed on apoptotic cells, and phosphorylcholine monoclonal immunoglobulin (Ig)G antibodies (PC‐mAb) have anti‐inflammatory properties. In this study, we hypothesize that PC‐mAb treatment reduces adverse cardiac remodelling and infarct size (IS) following unreperfused transmural myocardial infarction (MI). Unreperfused MI was induced by permanent ligation of the left anterior descending (LAD) coronary artery in hypercholesterolaemic APOE*3‐Leiden mice. Three weeks following MI, cardiac magnetic resonance (CMR) imaging showed a reduced LV end‐diastolic volume (EDV) by 21% and IS by 31% upon PC‐mAb treatment as compared to the vehicle control group. In addition, the LV fibrous content was decreased by 27% and LV wall thickness was better preserved by 47% as determined by histological analysis. Two days following MI, CCL2 concentrations, assessed by use of ELISA, were decreased by 81% and circulating monocytes by 64% as assessed by use of FACS analysis. Additionally, local leucocyte infiltration determined by immunohistological analysis showed a 62% decrease after three weeks. In conclusion, the local and systemic inflammatory responses are limited by PC‐mAb treatment resulting in restricted adverse cardiac remodelling and IS following unreperfused MI. This indicates that PC‐mAb holds promise as a therapeutic agent following MI limiting adverse cardiac remodelling.
The subtype‐specific molecular function of SPDEF in breast cancer and insights into prognostic significance
Authors: Ye Ting , Li Jingyuan , Feng Jia , Guo Jinglan , Wan Xue , Xie Dan , Liu Jinbo 
Published: July 2021

AbstractBreast cancer (BC) is a molecular diverse disease which becomes the most common malignancy among women worldwide. There are four BC subtypes (Luminal A, Luminal B, HER2‐enriched and Basal‐like) robustly established following gene expression pattern‐based characterization, behave significant differences in terms of their incidence, risk factors, prognosis and therapeutic sensitivity. Thus, there is an urgent need to provide mechanism research, treatment strategies and/or prognosis evaluation based on the patient stratification of BC subtypes. The prostate‐derived ETS factor SPDEF was first identified as an activator of prostate specific antigen, and then, the involvements in many aspects of BC have been proposed. However, the subtype‐specific molecular function of SPDEF in BC and insights into prognostic significance have not been clearly elucidated. This study demonstrated for the first time that SPDEF may play a diversity role in the expression levels, clinicopathologic importance, biological function and prognostic evaluation in BC via bioinformatics and experimental evidence, which mainly depends on different BC subtyping. In summary, our findings would help to better understand the possible mechanisms of various BC subtypes and to find possible candidate genes for prognostic and therapeutic usage.
Three‐year efficacy and safety of certolizumab pegol for the treatment of plaque psoriasis: results from the randomized phase 3 CIMPACT trial
Authors: Warren R. B. , Lebwohl M. , Sofen H. , Piguet V. , Augustin M. , Brock F. , C. Arendt  , Fierens F. , Blauvelt A. 
Published: July 2021

AbstractBackgroundCertolizumab pegol (CZP) is an Fc‐free, PEGylated anti‐tumor necrosis factor biologic.ObjectivesTo report 3‐year outcomes from the CIMPACT (NCT02346240) phase 3, CZP in moderate to severe plaque psoriasis, randomized controlled trial.MethodsAdults were randomized 3:3:3:1 to CZP 200 mg every other week (Q2W), CZP 400 mg Q2W, etanercept biweekly or placebo. At Week 16, CZP‐ and etanercept‐treated PASI 75 responders were re‐randomized to CZP 200 mg Q2W, CZP 400 mg Q4W, CZP 400 mg Q2W or placebo for maintenance treatment; PASI 75 non‐responders entered an open‐label escape CZP 400 mg Q2W arm. Patients entering the open‐label extension (OLE; Weeks 48–144) from blinded treatment received CZP 200 mg Q2W.ResultsDouble‐blinded results have been reported previously. 261 patients received 200 mg Q2W upon OLE entry. PASI 75 response was maintained in patients continuing 200 mg Q2W treatment through Weeks 16–144 (Week 144: 96.2%). In patients dosed down at Week 48 (double‐blinded 400 mg to 200 mg Q2W), PASI 75 decreased (Week 48: 98.7%; Week 144: 85.9%). In patients who received placebo through Weeks 16–48, PASI 75 response decreased (Week 48: 60.4%), then increased following Week 48 switch to 200 mg Q2W (Week 144: 95.1%). 48 and 36 patients initially randomized to 200 and 400 mg Q2W, respectively, were Week 16 PASI 75 non‐responders and entered the escape arm; at Week 144, 71.8% and 78.2% achieved PASI 75. No new safety signals were identified.ConclusionsResponse to CZP was durable over three years; no new safety signals were identified.
Topical calcineurin inhibitors as a double‐edged sword in rosacea: A systematic review
Authors: Zhang Hanlin , Yang Leyan , Wang Yuchen , Zhang Dingyue , Tang Keyun , Fang Rouyu , Sun Qiuning 
Published: July 2021

AbstractBackgroundRosacea is a chronic inflammatory disease mainly with skin or ocular manifestations. Topical calcineurin inhibitors, pimecrolimus and tacrolimus, can be used to treat rosacea. However, they can also induce rosacea‐like eruptions.AimsThis study systematically reviewed the double‐edged sword effects of pimecrolimus and tacrolimus on rosacea.MethodsFour databases were retrieved to search for articles on the effects of pimecrolimus and tacrolimus on rosacea, including Cochrane Library, Embase, PubMed, and Web of Science. Only English articles were included in the systematic review. Relevant data were collected, and the levels of evidence were evaluated.Results28 articles published between 2001 and 2016 were included. 11 articles were about pimecrolimus as the treatment of rosacea, 4 articles were about the pimecrolimus‐induced rosacea, 9 articles were about tacrolimus as the treatment of rosacea, and 4 articles were about tacrolimus‐induced rosacea. Participants for each study ranged from 1 to 200. Several types of outcome measurements were used for these publications.ConclusionsBoth pimecrolimus and tacrolimus might have double‐edged sword effects on rosacea. Pimecrolimus and tacrolimus could be effective for rosacea. However, both of them could also induce rosacea. Larger, randomized, controlled studies on pimecrolimus and tacrolimus as the treatment of rosacea and studies on the mechanisms of pimecrolimus and tacrolimus in treating or inducing rosacea are needed. This systematic review emphasized the double‐edged sword role of topical calcineurin inhibitors in rosacea, which may pave the way for future research.
Association of insomnia and multidimensional frailty in community‐dwelling older adults: A cross‐sectional survey
Authors: Fan Junyao , Liu Yueting , Wang Quan , Zhao Huimin , Kong Linglin , Li Jie 
Published: July 2021

AbstractObjectiveTo evaluate the relationship between insomnia and multidimensional frailty.BackgroundFrailty has major implications on adverse health outcomes of older adults. In recent years, multidimensional nature of frailty has been increasingly recognised. Many frail older adults also suffer from insomnia.MethodsThis was a cross‐sectional observational study including 454 community‐dwelling adults aged 60 and older. Insomnia was defined as a subjective experience of inadequate sleep duration or quality that affects social functioning during the day, based on the Athens Insomnia Scale (AIS), and multidimensional frailty was based on Tilburg Frailty Indicator (TFI). The STROBE checklist was used to guide the submission.ResultsMean age was 69.1 years old, 211 (46.5%) of participants suffered from insomnia, and 185 (40.7%) of participants were frail. There was a significant relationship between insomnia and multidimensional frailty (physical, psychological and social dimensions). Insomnia was associated with frailty, adjusting for sociodemographic characteristics and comorbidity OR of 6.863 (95% CI: 4.237–11.116).ConclusionFrailty was independently predicted by insomnia. Future researches should determine whether there is a causal relationship between insomnia and multidimensional frailty, with the ultimate goal of providing interventions to reverse or prevent frailty.Relevance to clinical practiceThis study emphasises the importance of assessment and treatment of insomnia, potentially contributing to the reversion and prevention of frailty in community‐dwelling older adults.