bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early and late stage MPN patients show distinct gene expression profiles in CD34+ cells
Authors: Baumeister Julian , Maié Tiago , Chatain Nicolas , Gan Lin , Weinbergerova Barbora , de Toledo Marcelo A. S. , Eschweiler Jörg , Maurer Angela , Mayer Jiri , Kubesova Blanka , Racil Zdenek , Schuppert Andreas , Costa Ivan , Koschmieder Steffen , Brümmendorf Tim H. , Gezer Deniz 
Published: August 2021

AbstractMyeloproliferative neoplasms (MPN), comprising essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), are hematological disorders of the myeloid lineage characterized by hyperproliferation of mature blood cells. The prediction of the clinical course and progression remains difficult and new therapeutic modalities are required. We conducted a CD34+ gene expression study to identify signatures and potential biomarkers in the different MPN subtypes with the aim to improve treatment and prevent the transformation from the rather benign chronic state to a more malignant aggressive state. We report here on a systematic gene expression analysis (GEA) of CD34+ peripheral blood or bone marrow cells derived from 30 patients with MPN including all subtypes (ET (n = 6), PV (n = 11), PMF (n = 9), secondary MF (SMF; post-ET-/post-PV-MF; n = 4)) and six healthy donors. GEA revealed a variety of differentially regulated genes in the different MPN subtypes vs. controls, with a higher number in PMF/SMF (200/272 genes) than in ET/PV (132/121). PROGENγ analysis revealed significant induction of TNFα/NF-κB signaling (particularly in SMF) and reduction of estrogen signaling (PMF and SMF). Consistently, inflammatory GO terms were enriched in PMF/SMF, whereas RNA splicing–associated biological processes were downregulated in PMF. Differentially regulated genes that might be utilized as diagnostic/prognostic markers were identified, such as AREG, CYBB, DNTT, TIMD4, VCAM1, and S100 family members (S100A4/8/9/10/12). Additionally, 98 genes (including CLEC1B, CMTM5, CXCL8, DACH1, and RADX) were deregulated solely in SMF and may be used to predict progression from early to late stage MPN.
Graphical abstract
Moisture recycling and the potential role of forests as moisture source during European heatwaves
Authors: Pranindita Agnes , Wang-Erlandsson Lan , Fetzer Ingo , Teuling Adriaan J. 
Published: August 2021

AbstractHeatwaves are extreme weather events that have become more frequent and intense in Europe over the past decades. Heatwaves are often coupled to droughts. The combination of them lead to severe ecological and socio-economic impacts. Heatwaves can self-amplify through internal climatic feedback that reduces local precipitation. Understanding the terrestrial sources of local precipitation during heatwaves might help identify mitigation strategies on land management and change that alleviate impacts. Moisture recycling of local water sources through evaporation allows a region to maintain precipitation in the same region or, by being transported by winds, in adjacent regions. To understand the role of terrestrial moisture sources for sustaining precipitation during heatwaves, we backtrack and analyse the precipitation sources of Northern, Western, and Southern sub-regions across Europe during 20 heatwave periods between 1979 and 2018 using the moisture tracking model Water Accounting Model-2layers (WAM-2layers). In Northern and Western Europe, we find that stabilizing anticyclonic patterns reduce the climatological westerly supply of moisture, mainly from the North Atlantic Ocean, and enhances the moisture flow from the eastern Euro-Asian continent and from within their own regions—suggesting over 10% shift of moisture supply from oceanic to terrestrial sources. In Southern Europe, limited local moisture sources result in a dramatic decrease in the local moisture recycling rate. Forests uniformly supply additional moisture to all regions during heatwaves and thus contribute to buffer local impacts. This study suggests that terrestrial moisture sources, especially forests, may potentially be important to mitigate moisture scarcity during heatwaves in Europe.
Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases
Authors: Feng Yuliang , Huang Wei , Paul Christian , Liu Xingguo , Sadayappan Sakthivel , Wang Yigang , Pauklin Siim 
Published: August 2021

AbstractMetabolic function and energy production in eukaryotic cells are regulated by mitochondria, which have been recognized as the intracellular ‘powerhouses’ of eukaryotic cells for their regulation of cellular homeostasis. Mitochondrial function is important not only in normal developmental and physiological processes, but also in a variety of human pathologies, including cardiac diseases. An emerging topic in the field of cardiovascular medicine is the implication of mitochondrial nucleoid for metabolic reprogramming. This review describes the linear/3D architecture of the mitochondrial nucleoid (e.g., highly organized protein-DNA structure of nucleoid) and how it is regulated by a variety of factors, such as noncoding RNA and its associated R-loop, for metabolic reprogramming in cardiac diseases. In addition, we highlight many of the presently unsolved questions regarding cardiac metabolism in terms of bidirectional signaling of mitochondrial nucleoid and 3D chromatin structure in the nucleus. In particular, we explore novel techniques to dissect the 3D structure of mitochondrial nucleoid and propose new insights into the mitochondrial retrograde signaling, and how it regulates the nuclear (3D) chromatin structures in mitochondrial diseases.
Endurance training-induced increase in muscle oxidative capacity without loss of muscle mass in younger and older resistance-trained men
Authors: Hendrickse Paul William , Venckunas Tomas , Platkevicius Justinas , Kairaitis Ramutis , Kamandulis Sigitas , Snieckus Audrius , Stasiulis Arvydas , Vitkiene Jolanta , Subocius Andrejus , Degens Hans 
Published: August 2021

AbstractWhile concurrent training is regularly used in older populations, the inverse relationship between fibre size and oxidative capacity suggests that endurance training in resistance-trained individuals may result in some loss of resistance training-induced gains in muscle mass, which may be more pronounced in older people. We investigated the impact of superimposed endurance training in younger (28.5 ± 4.8 years; n = 8) and older (67.5 ± 5.5 years; n = 7) highly resistance-trained men. Participants underwent a 10-week endurance cycling training programme consisting of five 6-min intervals at 75% max heart rate (HRmax) separated by 4-min intervals at 90% HRmax. The anatomical cross-sectional area (ACSA) of the thigh muscles, as determined with MRI, was 24% smaller in older compared to younger participants (p < 0.001). Although maximal oxygen consumption (VO2max) was also lower in the older group (p < 0.001), VO2max per kg body mass did not differ significantly between younger and older participants. Histological analyses of biopsies of the m. vastus lateralis showed that endurance training induced an increase in succinate dehydrogenase activity in both younger and older participants (p ≤ 0.043), and an increase in the number of capillaries around type I fibres (p = 0.017). The superimposed endurance training did not induce a significant decrease in thigh ACSA, fibre cross-sectional area, or knee extensor maximum voluntary isometric force. These observations indicate that adding endurance training to resistance training can lead to positive endurance-related adaptations without negative consequences for muscle size and strength in older and younger resistance-trained people.
Rapidly fatal SMARCA4-deficient undifferentiated sarcoma originating from hybrid hemosiderotic fibrolipomatous tumor/pleomorphic hyalinizing angiectatic tumor of the foot
Authors: Agaimy Abbas , Meidenbauer Norbert , Sukov William R. , Stoehr Robert , Vieth Michael , Roemer Frank , Grützmann Robert , Folpe Andrew L. 
Published: August 2021

AbstractPleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts and hemosiderotic fibrolipomatous tumor (HFLT) are two rare low-grade locally recurring neoplasms with predilection for the foot/ankle. Recent studies support a close link between the two entities, and origin of PHAT from HFLT and occurrence of hybrid HFLT/PHAT have been documented. Both lesions often harbor TGFBR3 or MGEA5 rearrangements. Rare sarcomas originating from HFLT/PHAT have been reported, typically resembling myxofibrosarcoma or myxoinflammatory fibroblastic sarcoma. We describe a novel SMARCA4-deficient undifferentiated sarcoma with rhabdoid features originating from hybrid HFLT/PHAT in the foot of a 54-year-old male. The tumor pursued a highly aggressive course with rapid regrowth after resection and multiple metastases resulting in patient’s death within 5 months, despite systemic chemotherapy. Immunohistochemistry revealed SMARCA4 loss in the undifferentiated sarcoma, but not in the HFLT/PHAT. Molecular testing confirmed TGFBR3/MGEA5 rearrangements. This report expands the phenotypes of sarcomas developing from pre-existing PHAT/HFLT.
Dissecting whole-brain conduction delays through MRI microstructural measures
Authors: Mancini Matteo , Tian Qiyuan , Fan Qiuyun , Cercignani Mara , Huang Susie Y. 
Published: August 2021

AbstractNetwork models based on structural connectivity have been increasingly used as the blueprint for large-scale simulations of the human brain. As the nodes of this network are distributed through the cortex and interconnected by white matter pathways with different characteristics, modeling the associated conduction delays becomes important. The goal of this study is to estimate and characterize these delays directly from the brain structure. To achieve this, we leveraged microstructural measures from a combination of advanced magnetic resonance imaging acquisitions and computed the main determinants of conduction velocity, namely axonal diameter and myelin content. Using the model proposed by Rushton, we used these measures to calculate the conduction velocity and estimated the associated delays using tractography. We observed that both the axonal diameter and conduction velocity distributions presented a rather constant trend across different connection lengths, with resulting delays that scale linearly with the connection length. Relying on insights from graph theory and Kuramoto simulations, our results support the approximation of constant conduction velocity but also show path- and region-specific differences.
Barriers to Trauma Care in South and Central America: a systematic review
Authors: Kinder Florence , Mehmood Sarah , Hodgson Harry , Giannoudis Peter , Howard Anthony 
Published: August 2021

Abstract
Introduction
Trauma is widespread in Central and South America and is a significant cause of morbidity and mortality. Providing high quality emergency trauma care is of great importance. Understanding the barriers to care is challenging; this systematic review aims to establish current the current challenges and barriers in providing high-quality trauma care within the 21 countries in the region.

Methods
OVID Medline, Embase, EBM reviews and Global Health databases were systematically searched in October 2020. Records were screened by two independent researchers. Data were extracted according to a predetermined proforma. Studies of any type, published in the preceding decade were included, excluding grey literature and non-English records. Trauma was defined as blunt or penetrating injury from an external force. Studies were individually critically appraised and assessed for bias using the RTI item bank.

Results
57 records met the inclusion criteria. 20 countries were covered at least once. Nine key barriers were identified: training (37/57), resources and equipment (33/57), protocols (29/57), staffing (17/57), transport and logistics (16/57), finance (15/57), socio-cultural (13/57), capacity (9/57), public education (4/57).

Conclusion
Nine key barriers negatively impact on the provision of high-quality trauma care and highlight potential areas for improving care in Central & South America. Many countries in the region, along with rural areas, are under-represented by the current literature and future research is urgently required to assess barriers to trauma management in these countries.
No funding was received. Clinical Trial Registration: PROSPERO CRD42020220380.
How I do it: proximal control in parkinson’s triangle for a very large paraclinoid aneurysm
Authors: Volovici Victor , Dammers Ruben 
Published: August 2021

Abstract
Background
Paraclinoid aneurysms, especially when they are large, can be quite difficult to treat, both endovascularly and through microsurgical clip reconstruction. There are many possibilities to approach this region surgically, and most hinge on total or partial removal of the anterior clinoid process. Gaining proximal control may be a challenge when space is limited, which is why Parkinson’s triangle may be a viable alternative in some cases.

Methods
We describe in a stepwise fashion the steps used to reconstruct a very large paraclinoid aneurysm. We first attempted to gain proximal control in the carotid cave and later in Parkinson’s triangle because of limited manoeuvrability.

Conclusion
Proximal control in Parkinson’s triangle can be a safe alternative when the post-clinoidal segment of the internal carotid artery (ICA) is short and working space is limited in paraclinoid aneurysm microsurgical clip reconstruction.
Associations between age and cortisol awakening response in patients with borderline personality disorder
Authors: Rausch Juliane , Flach Elisa , Panizza Angelika , Brunner Romuald , Herpertz Sabine C. , Kaess Michael , Bertsch Katja 
Published: August 2021

AbstractPatients with borderline personality disorder (BPD) often display increased stress vulnerability, which may be linked to altered hypothalamus–pituitary–adrenal (HPA) axis functioning. Corresponding deviations of the cortisol awakening response (CAR) are presumed to mirror maladaptive neuroendocrine processes, which may explain why CARs are increased compared to healthy controls (HC). Prior research speculated that these alterations may be caused by early life stress and/or chronic stress related to the ongoing burden of the disorder. Yet, it remains to be investigated how BPD influences CAR in the course of development. Therefore, the current study examined CAR in female adolescents and adults with BPD compared to HC with a particular focus on associations with age. These potential associations were especially focused, as it was hypothesized that the CAR would be even more elevated (i.e., higher) in older individuals with BPD. CAR was assessed in 54 female individuals with BPD (aged 15–40 years) and 54 sex-, age-, and intelligence-matched HC (aged 15–48 years). Group differences were investigated and analyses of covariance using age as continuous predictor were performed to analyze potential developmental associations with CAR alongside BPD-specific effects. Pearson’s correlations were calculated to examine associations between CAR and age. Analyses were repeated with potential confounders as control factors. Results not only demonstrated increased CARs in female individuals with BPD compared to HC but demonstrated elevated CARs with increasing age in BPD individuals exclusively. Effects remained stable after controlling for potential confounders. Thereby, findings suggest that endocrine alterations in BPD may reinforce with increasing age and BPD chronicity.
Formal requirements modeling for cyber-physical systems engineering: an integrated solution based on FORM-L and Modelica
Authors: Bouskela Daniel , Falcone Alberto , Garro Alfredo , Jardin Audrey , Otter Martin , Thuy Nguyen , Tundis Andrea 
Published: August 2021

AbstractThe increasing complexity of cyber-physical systems (CPSs) makes their design, development and operation extremely challenging. Due to the nature of CPS that involves many heterogeneous components, which are often designed and developed by organizations belonging to different engineering domains, it is difficult to manage, trace and verify their properties, requirements and constraints throughout their lifecycle by using classical techniques. In this context, the paper presents an integrated solution to formally define system requirements and automate their verification through simulation. The solution is based on the FOrmal Requirements Modeling Language and the Modelica language. The solution is exemplified through two case studies concerning a Trailing-Edge High-Lift system and a Heating, Ventilation and Air Conditioning system.
On the manipulability of a class of social choice functions: plurality kth rules
Authors: Bednay Dezső , Tasnádi Attila , Yadav Sonal 
Published: August 2021

AbstractIn this paper we introduce the plurality kth social choice function selecting an alternative, which is ranked kth in the social ranking following the number of top positions of alternatives in the individual ranking of voters. As special case the plurality 1st is the same as the well-known plurality rule. Concerning individual manipulability, we show that the larger k the more preference profiles are individually manipulable. We also provide maximal non-manipulable domains for the plurality kth rules. These results imply analogous statements on the single non-transferable vote rule. We propose a decomposition of social choice functions based on plurality kth rules, which we apply for determining non-manipulable subdomains for arbitrary social choice functions. We further show that with the exception of the plurality rule all other plurality kth rules are group manipulable, i.e. coordinated misrepresentation of individual rankings are beneficial for each group member, with an appropriately selected tie-breaking rule on the set of all profiles.
Is there an imbalance in the supply and demand for universal accessibility knowledge? Twenty years of UAIS papers viewed through the lens of WCAG
Authors: Sandnes Frode Eika 
Published: August 2021

AbstractPurpose: Some universal accessibility practitioners have voiced that they experience a mismatch in the research focus and the need for knowledge within specialized problem domains. This study thus set out to identify the balance of research into the main areas of accessibility, the impact of this research, and how the research profile varies over time and across geographical regions. Method: All UAIS papers indexed in Scopus were analysed using bibliometric methods. The WCAG taxonomy of accessibility was used for the analysis, namely perceivable, operable, and understandable. Results: The results confirm the expectation that research into visual impairment has received more attention than papers addressing operable and understandable. Although papers focussing on understandable made up the smallest group, papers in this group attracted more citations. Funded research attracted fewer citations than research without funding. The breakdown of research efforts appears consistent over time and across different geographical regions. Researchers in Europe and North America have been active throughout the last two decades, while Southeast Asia, Latin America, and Middle East became active in during the last five years. There is also seemingly a growing trend of out-of-scope papers. Conclusions: Based on the findings, several recommendations are proposed to the UAIS editorial board.
Counteracting flawed landslide data in statistically based landslide susceptibility modelling for very large areas: a national-scale assessment for Austria
Authors: Lima Pedro , Steger Stefan , Glade Thomas 
Published: August 2021

AbstractThe reliability of input data to be used within statistically based landslide susceptibility models usually determines the quality of the resulting maps. For very large territories, landslide susceptibility assessments are commonly built upon spatially incomplete and positionally inaccurate landslide information. The unavailability of flawless input data is contrasted by the need to identify landslide-prone terrain at such spatial scales. Instead of simply ignoring errors in the landslide data, we argue that modellers have to explicitly adopt their modelling design to avoid misleading results. This study examined different modelling strategies to reduce undesirable effects of error-prone landslide inventory data, namely systematic spatial incompleteness and positional inaccuracies. For this purpose, the Austrian territory with its abundant but heterogeneous landslide data was selected as a study site. Conventional modelling practices were compared with alternative modelling designs to elucidate whether an active counterbalancing of flawed landslide information can improve the modelling results. In this context, we compared widely applied logistic regression with an approach that allows minimizing the effects of heterogeneously complete landslide information (i.e. mixed-effects logistic regression). The challenge of positionally inaccurate landslide samples was tackled by elaborating and comparing the models for different terrain representations, namely grid cells, and slope units. The results showed that conventional logistic regression tended to reproduce incompleteness inherent in landslide training data in case the underlying model relied on explanatory variables directly related to the data bias. The adoption of a mixed-effects modelling approach appeared to reduce these undesired effects and led to geomorphologically more coherent spatial predictions. As a consequence of their larger spatial extent, the slope unit–based models were able to better cope with positional inaccuracies of the landslide data compared to their grid-based equals. The presented research demonstrates that in the context of very large area susceptibility modelling (i) ignoring flaws in available landslide data can lead to geomorphically incoherent results despite an apparent high statistical performance and that (ii) landslide data imperfections can actively be diminished by adjusting the research design according to the respective input data imperfections.
Improved PrEP Awareness and Use among Trans Women in San Francisco, California
Authors: Wilson Erin C. , Hernandez Christopher J. , Scheer Susan , Trujillo Dillon , Arayasirikul Sean , Sicro Sofia , McFarland Willi 
Published: August 2021

AbstractTransgender women face a serious risk of HIV infection. Despite this, there is limited knowledge and use of Pre-exposure prophylaxis (PrEP). We measured the continuity of prevention across services in the PrEP cascade and correlates of PrEP use among trans women in San Francisco enrolled in the 2019/20 National HIV Behavioral Surveillance Study. Knowledge and use of PrEP among trans women in San Francisco increased in recent years; almost all (94.0%) had heard about PrEP, 64.7% had discussed PrEP with a healthcare provider, and 44.8% had taken PrEP in the past 12 months. PrEP use was associated with participation in a PrEP demonstration project (aOR = 31.44, p = 0.001) and condomless receptive anal intercourse (aOR = 3.63, p = 0.024). Injection drug use was negatively associated (aOR = 0.19, p = 0.014). Efforts are needed to combat the gender-based stigma and discrimination faced by trans women, which can result in avoidance and mistrust of the medical system.