bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gesundheitsressourcen von Altenpflegepersonal – Ergebnisse einer Querschnittsstudie
Authors: Gutsch Carolin , Brinkmann Lisa , Frahm Gesa , Otto Ann-Kathrin , Bischoff Laura Luise , Fenger Annika , Wollesen Bettina 
Published: February 2021

Zusammenfassung
Ziel der Studie Altenpflegekräfte sind hohen Arbeitsbelastungen ausgesetzt, die häufig zu Stress, Arbeitsunfähigkeit und frühzeitigem Berufsausstieg führen. Persönliche Ressourcen können Arbeitsanforderungen ausgleichen und gesundheitsförderlich wirken. Um Interventionsmaßnahmen zu entwickeln, untersucht diese Studie welche Ressourcen Altenpflegekräfte besitzen und wie sich diese auf die Stressentstehung auswirken.
Methodik N=195 Altenpflegekräfte (87,4% weiblich, 40,1±12,2 Jahre). Die Datenerhebung erfolgte mittels validiertem Fragebogen, bestehend aus dem Fragebogen nach Slesina, dem Nordischen Fragebogen, dem SF-12, persönlichen Ressourcen (nach WHO-Kriterien), dem AVEM sowie der SSCS-Skala aus dem TICS, in deren Abhängigkeit die Altenpflegekräfte in gestresst und nicht-gestresst unterteilt wurden. Eine vierstufige Regressionsanalyse untersuchte in der Folge Einflussfaktoren auf die Stressentstehung.
Ergebnisse Nicht-gestresste Altenpflegekräfte fühlten sich durch arbeitsbezogene Belastungsfaktoren weniger belastet, hatten geringere körperliche Beschwerden, besaßen ein besseres körperliches (p <0,001) und psychisches Wohlbefinden (p <0,001), stärkere persönliche Ressourcen und verfügten über ein besseres Arbeitsbewältigungsverhalten. Die Regressionsanalyse zeigte, dass Ressourcen wie die Zufriedenheit mit dem Gesundheitszustand, das Ernährungsverhalten, Ruhe und Gelassenheit, das Energielevel der vergangenen Wochen sowie das persönliche Stresserleben das körperliche und psychische Wohlbefinden verbessern, jedoch bei einem manifestierten gesundheitsriskantem Arbeitsbewältigungsverhalten die Stressentstehung nicht abmildern können (R²=0,760).
Schlussfolgerung Bei der Entwicklung von Stresspräventionsmaßnahmen sollte die Stärkung persönlicher Ressourcen im Vordergrund stehen und arbeitsbezogene Verhaltens- und Erlebensmuster berücksichtig werden.
Goldimplantation: Neue Therapieform bei schmerzhafter Arthrose
Authors: Endrizzi Melanie 
Published: February 2021

ZusammenfassungSchmerzhafte Arthrose bildet ein häufiges Problem mit zunehmendem Lebensalter. Die konventionellen Therapien bringen nicht bei allen Patienten die erhofften Behandlungserfolge.Die noch relativ junge Therapieform der Goldimplantation bietet eine zusätzliche Möglichkeit, die Beschwerden zu lindern. Dabei werden in Lokalanästhesie ca. 2 mm lange 24-karätige Feingolddrahtstücke um das schmerzende Gelenk herum implantiert. Erfahrungen aus der Praxis zeigen, dass die Therapie komplikationsarm und gut verträglich ist. Entzündungen im Gelenk, Schwellungen und Schmerzen werden reduziert. Als Wirkmechanismus werden entzündungshemmende Eigenschaften des Goldes vermutet. Praxiserfahrungen und erste Untersuchungen zeigen, dass die Goldimplantation bei Arthroseschmerzen und Bewegungseinschränkungen eine effektive und sichere Methode sein kann.Die Autorin erläutert anhand eines Fallberichts aus ihrer Praxis das Vorgehen und die möglichen Erfolge.
Clinical Course and Treatment Paradigms for JIA-related Uveitis and Pars Planitis Uveitis Using Precise Ocular Investigational Methods
Authors: Papasavvas Ioannis , Gehrig Béatrice , Herbort Carl Peter 
Published: February 2021

AbstractPurpose The aim of this study was to report on the disease course and management modalities in patients with juvenile idiopathic arthritis-related uveitis (JIA uveitis) or intermediate uveitis of the pars planitis type (PP) who were followed up using precise ocular investigational techniques.Methods This is a retrospective single-centre study. All charts of patients seen in our centre over 15 years (2005 – 2019) with a diagnosis of JIA uveitis or PP were retrieved and analysed for clinical course, severity of inflammation, type of management, and the role played by precise investigational techniques (laser flare photometry [LFP], optical coherence tomography [OCT] and fluorescein angiography [FA]) in therapeutic decisions.Results 26 out of a total of 64 patients with sufficient data could be included in the study. Mean age was 11.2 years (SD ± 5.4). 13/26 (50%) patients presented with JIA uveitis and 13/26 (50%) with PP. PP patients had a more benign course (mean LFP values at presentation 9.9 ± 3.2 ph/ms), and at the end of follow-up, only 2/13 PP patients (15%) still needed systemic treatment. In contrast, JIA uveitis as a whole was more severe, although benign forms were present (LFP values at presentation 105.9 ± 19.5 ph/ms), and at the end of follow-up, 5/13 patients (38%) still needed systemic treatment. Complications were also more severe and frequent in JIA uveitis patients. In 6/26 patients (24%, 3 JIA and 3 PP patients), the precise monitoring methods allowed unjustified systemic treatment to be discontinued, and to avoid such a treatment, it was recommended that it should be replaced by topical treatment or observation.Conclusion Nowadays, new investigational techniques have made precise follow-up of uveitis possible. We determined the precise inflammatory pattern of JIA uveitis and PP, which is crucial information to determine the therapeutic intervention. As these two entities are common in young and paediatric patients, such precise monitoring is essential to determine adequate treatment paradigms and avoid unnecessary systemic treatment, especially corticosteroids. When the ophthalmic status requires it, multidisciplinary collaboration between the ophthalmologist, the paediatrician and the rheumatologist may be needed to offer optimal management to the patient. In cases of purely ocular involvement, it is the ophthalmologist who should determine the management.
Tratamento artroscópico do impacto femoroacetabular na epifisiólise capital femoral proximal: Relato de caso
Authors: Pedroni Marco Antonio , Schuroff Ademir Antonio , Chang Rafael Wei Min Leal , Batista Bruno Bellaguarda 
Published: February 2021

ResumoA epifisiólise capital femoral proximal (ECFP) pode resultar em impacto femoroacetabular (IFA) do quadril em até um terço dos casos. A deformidade residual em came ou “cabo de pistola” está associada a lesão condrolabral, resultando em dor, incapacidade funcional, e osteoartrose precoce. O tratamento artroscópico com osteocondroplastia mostrou-se benéfico em um caso selecionado de IFA secundário a ECFP.
Pediatric Patient with Lemierre Syndrome of the External Jugular Vein: Case Report and Literature Review
Authors: Schwarz Yehuda , Habashi Nadeem , Rosenfeld-Yehoshua Noa , Soikher Eugene , Marom Tal , Tamir Sharon Ovnat 
Published: February 2021

Abstract
Introduction Lemierre syndrome (LS) involving the external jugular vein (EJV) is rare, and only a few cases have been reported in the literature.
Objectives To report a case of LS involving the external jugular vein as well as to make a review of the literature regarding both diagnosis and management strategies.
Data Synthesis We describe a case of LS involving the EJV and review the literature of previously published articles to search for additional cases. A PubMed, Embase, Scopus, and Web of science-based search was performed to determine the scope of coverage in well-reported articles in English. Twenty-one papers were retrieved and documented for age, incidence, pathogen, presenting symptoms, imaging, treatment, and outcome, which were noted for each of these cases. In our literature review of 21 papers, there were 16 patients (61%) in their 2nd and 3rd decades of life. Lemierre syndrome was shown to affect females and males equally. The presenting symptoms were a sore throat and fever. Treatment requires intravenous antibiotics, and there is no consensus regarding treatment with anticoagulation.
Conclusions The present case report and review of the literature emphasize the importance of history taking as well as physical examination in what seems to be a case of simple tonsillitis.
Avaliação do estado nutricional e correlação com complicações cirúrgicas em pacientes idosos submetidos a tratamento cirúrgico de fratura do fêmur proximal
Authors: Dias Tiane Raquel da Silva , Batista Bruno Bellaguarda , Chang Rafael Wei Min Leal , Noriega Jorge Enrique Acosta , Figueiredo Giuseppe Lemos Pertoti de 
Published: February 2021

Resumo
Objetivo Avaliar e correlacionar o estado nutricional com possíveis complicações no pós-operatório imediato de pacientes submetidos a tratamento cirúrgico de fraturas de fêmur proximal.
Métodos Estudo transversal prospectivo analítico e de abordagem quantitativa, tendo como população-alvo pacientes com idade igual ou superior a 60 anos, internados em uma instituição hospitalar no Amazonas, submetidos a tratamento cirúrgico de fraturas de fêmur proximal. Foram avaliadas as complicações cirúrgicas no pós-operatório imediato e sua relação com o estado nutricional através da mini avaliação nutricional (MAN), assim como a mensuração da contagem de linfócitos e albumina e a sua correlação com o tempo de internação.
Resultados A amostra foi composta por 19 pacientes idosos, de ambos os sexos, com média de idade de 70,8 anos. A maioria dos pacientes (68,4%) eram do sexo feminino. Por meio da variável antropométrica índice de massa corporal (IMC), identificou-se a presença de desnutrição em 15,8% dos pacientes e, por meio da MAN, de 31,6%. Na avaliação do cálculo da contagem total de linfócitos, 100% da amostra apresentou associação positiva com desnutrição em graus variáveis e, fazendo-se uso da albumina sérica como parâmetro, a desnutrição foi identificada em 89,4%. Os pacientes desnutridos apresentaram a maior média de tempo de internação. As complicações cirúrgicas, por infecções do sítio cirúrgico, ocorreram em 10,5% nos pacientes em risco nutricional.
Conclusão Neste estudo, observou-se maior índice de complicações no pós-operatório em idosos diagnosticados com desnutrição.
Quality of Life in Patients with Nasal Obstruction after Septoplasty: A Single Institution Prospective Observational Study
Authors: Dąbrowska-Bień Justyna , Skarżyński Henryk , Górski Sebastian Filip , Skarżyński Piotr Henryk 
Published: February 2021

Abstract
Introduction Nasal obstruction is a common symptom in otorhinolaryngological practice. It can impact significantly on the quality of life of the individual.
Objective The primary goal of the present study was to evaluate quality of life after septoplasty in adults with nasal obstruction. A secondary goal was to assess the effectiveness of septoplasty.
Methods This was a single institution prospective observational study. Patients had experienced septal deviation and symptomatic nasal obstruction with no benefit from medical treatment. There were 51 patients who completed the Nasal Obstruction Symptom Evaluation (NOSE-POL) scale as well as theVisual Analogue Scale (VAS) before undergoing septoplasty, 3 months later, and finally 7 months after surgery. Patients evaluated changes in their nasal obstruction and changes in their quality of life using the Clinical Global Impression Scale (CGI-S).
Results There was a significant improvement in nasal obstruction after septoplasty. Before septoplasty, the mean score on NOSE was 60.3 ± 20.4; 3 months after surgery, it was 32.9 ± 16.8; and 7 months after surgery it was 39.6 ± 33.2. The VAS results also proved a significant enhancement in nasal obstruction after septoplasty. Patients reported an improvement in nasal obstruction as well as a positive change in quality of life, confirming the effectiveness of septoplasty.
Conclusions In patients with deformed septum, septoplasty contributes to high satisfaction of the patient and a compelling improvement in disease-specific quality of life. The NOSE-POL questionnaire is a useful tool for measuring the outcomes of this procedure.
Predictive Factors of Recurrence of Papillary Thyroid Microcarcinomas: Analysis of 2,538 Patients
Authors: Carvalho Andre de Ywata , Kohler Hugo Fontan , Gomes Camila Couto , Vartanian José Guilherme , Kowalski Luiz Paulo 
Published: February 2021

Abstract
Introduction The incidence of papillary thyroid microcarcinoma (PTMC) has increased, and its treatment remains controversial.
Objective To identify the clinical and pathological factors predictive of tumor recurrence.
Methods We retrospectively analyzed 2,538 consecutive patients treated for PTMC, most submitted to total thyroidectomy (98%) followed by radioactive iodine (RAI) ablation (51.7%) at a cancer center from 1996 to 2015. The patients were stratified according to the American Thyroid Association (ATA) risk categories (low, intermediate, or high), and the clinicopathological features were evaluated by multivariate Cox regression analysis to identify independent prognostic factors for recurrence.
Results After a mean follow-up of 58 months (range: 3 to 236.5 months), tumor recurrence was diagnosed in 63 (2.5%) patients, mostly in the lymph nodes. Distant metastasis occurred in 2 (0.1%) patients. There were no cancer-related deaths. The multivariate analysis showed that age < 55 years (p = 0.049; hazard ratio [HR]: 2.54; 95% confidence interval [95%CI]: 0.95 to 0.99), multifocality (p = 0.032; HR: 1.76; 95%CI: 1.05 to 2.96), and the presence of lymph-node metastasis (p < 0.001; HR: 3.69; 95%CI: 2.07–6.57) were independent risk factors for recurrence. Recurrence was observed in 29 (1.5%) out of 1,940 low-risk patients, 32 (5.4%) out of 590 intermediate-risk patients, and in 2 (25%) out of 8 high-risk patients.
Conclusions The prognosis of PTMC is excellent, favoring a conservative treatment for most patients. Age < 55 years, multifocality, and node metastasis at diagnosis, as well the ATA staging system effectively predict the risk of recurrence. The presence of these risk factors can help identify patients who should be considered for more aggressive management and more frequent follow-up.
Van Buchem Disease: First Case Report from the Indian Subcontinent with an Early Presentation
Authors: Maheshwari Saurabh , Yangzom Sonam , Bhanu K. Uday , Rajesh Uddandam , Narayan Ashok 
Published: February 2021

AbstractVan Buchem disease is a rare autosomal recessive genetic disorder that causes a compromised inhibitory feedback mechanism resulting in increased bone formation and overgrowth of the skeleton leading to a variety of neurological symptoms. It has been reported in less than 50 patients most of which were in western Europe. We report the first case of this condition from the Indian subcontinent with an early presentation. This patient presented with a global delay in attaining the developmental milestones and progressive reduction in visual acuity and loss of hearing. He had dysmorphic facies, multiple cranial nerve palsies, and severe visual and auditory deficits. Imaging revealed sclerosing bone dysplasia. This case illustrates the clinical and imaging findings of this rare condition.
Atualização no tratamento da hérnia discal cervical: Manejo conservador e indicações de diferentes técnicas cirúrgicas
Authors: Silva Luis Eduardo Carelli Teixeira da , Almeida Luiz Eduardo Pereira Costa Assis de 
Published: February 2021

ResumoA dor cervical e radicular devido à hérnia de disco é uma causa comum de uma visita a um cirurgião ortopédico. É importante saber diagnosticar, tratar e inicialmente.Quais são as melhores opções para tratar a hérnia de disco hoje em dia? Este artigo faz uma revisão da literatura e atualização sobre o tratamento clínico e cirúrgico da herniação do disco cervical.
Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases
Authors: Kanduc Darja 
Published: February 2021

AbstractRecently, it was found that proteomes from poliovirus, measles virus, dengue virus, and severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) have high molecular mimicry at the heptapeptide level with the human proteome, while heptapeptide commonality is minimal or absent with proteomes from nonhuman primates, that is, gorilla, chimpanzee, and rhesus macaque. To acquire more data on the issue, analyses here have been expanded to Ebola virus, Francisella tularensis, human immunodeficiency virus-1 (HIV-1), Toxoplasma gondii, Variola virus, and Yersinia pestis. Results confirm that heptapeptide overlap is high between pathogens and Homo sapiens, but not between pathogens and primates. Data are discussed in light of the possible genetic bases that differently model primate phenomes, thus possibly underlying the zero/low level of molecular mimicry between infectious agents and primates. Notably, this study might help address preclinical vaccine tests that currently utilize primates as animal models, since autoimmune cross-reactions and the consequent adverse events cannot occur in absentia of shared sequences.
Percentile Charts for Body Mass Index of Indian Down Syndrome Children
Authors: Kaur Harvinder , Bhalla Anil Kumar , Panigrahi Inusha 
Published: February 2021

AbstractGrowth charts are used to detect growth impairment, overweight, and obesity among Down syndrome (DS) children belonging to different population groups. Due to nonavailability of similar information, age, and gender specific body mass index (BMI) charts for DS children of Indian origin, based on serial data, have been developed. A total of 752 boys and 373 girls diagnosed as cases of DS at <1 month to 10 years of age enrolled from the “genetic clinic” were followed up in the “growth clinic/growth laboratory” of the institute, following a mixed-longitudinal growth research design. BMI was calculated from body weight and length/height measured at 6-month-age intervals by using standardized techniques and instruments. Age and sex-specific percentile growth charts for BMI were generated for age range <1 month to 10 years by using the LMS method. DS children remained wasted (BMI <3rd percentile) up to 6 months of age; thereafter, BMI increased to exhibit close similarity with their normal Multicentre Growth Reference Study (World Health Organization 2006) and Indian Academy of Pediatrics (2015) counterparts up to 5 to 10 years, respectively. The percentage of obese DS girls (8.76%) outnumbered boys with DS (4.1%). The use of age and gender specific BMI growth charts may be made for comparative purpose, to assess nutritional status of Indian children with DS, to initiate suitable need-based intervention to improve their overall health and for timely institution of target interventions to prevent growth faltering in this vulnerable population.
Interface water-induced hydrophobic carbon chain unfolding in water
Authors: Xie Zhang , Li Zheng , Lou Gang , Liang Qing , Chen Jiang-Xing , Kou Jianlong , Wei Gui-Na 
Published: February 2021

Abstract
The folding and unfolding of the carbon chain, which is the basic constitutional unit of polymers, are important to the performance of the material. However, it is difficult to regulate conformational transition of the carbon chain, especially in an aqueous environment. In this paper, we propose a strategy to regulate the conformational transition of the carbon chain in water based on the all-atom molecular dynamics simulations. It is shown that the unfolded carbon chain will spontaneously collapse into the folded state, while the folded carbon chain will unfold with an external electric field. The regulation ability of the electric field is attributed to the electric field-induced redistribution of interface water molecules near the carbon chain. The demonstrated method of regulating conformational transition of the carbon chain in water in this study provides an insight into regulating hydrophobic molecules in water, and has great potential in drug molecule design and new polymer material development.
Ecological phylogeography and coalescent models suggest a linear population expansion ofAnastrepha fraterculus(Diptera: Tephritidae) in southern South America
Authors: Vilardi Juan César , Freilij Damián , Ferreyra Laura Inés , Gómez-Cendra Paula 
Published: February 2021

AbstractThis work is a first approach to an integrated view of the genetics, ecology and dispersion patterns of Anastrepha fraterculus in southern South America. We studied the association of genetic variation with geographical patterns and environmental variables to provide insight into the crucial factors that drive the structure and dynamics of fly populations. Data from a 417 bp mitochondrial COII gene fragment from seven Argentinian populations and one South Brazilian population (from five ecoregions grouped in three biomes) were used to identify population clusters using a model-based Bayesian phylogeographical and ecological clustering approach. The sequences were also analysed under a coalescent model to evaluate historical demographic changes. We identified 19 different haplotypes and two clusters differing in all the environmental covariables. The assumption of neutral evolution and constant population size was rejected, and the population growth parameters suggested a linear population expansion starting 2500 years before present. The most likely ancestral location is Posadas, from where A. fraterculus would have expanded southwards and westwards in Argentina. This result is consistent with Holocene changes and anthropic factors related to the expansion of the Tupí–Guaraní culture, 3000–1500 years before present.
A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologies
Authors: Yao Yinan , Kang Seong Su , Xia Yiyuan , Wang Zhi-Hao , Liu Xia , Muller Thorsten , Sun Yi E , Ye Keqiang 
Published: February 2021

Abstract
Amyloid-β precursor protein (APP) is sequentially cleaved by secretases and generates amyloid-β, the major components in senile plaques in Alzheimer’s disease. APP is upregulated in human Alzheimer’s disease brains. However, the molecular mechanism of how APP contributes to Alzheimer’s disease pathogenesis remains incompletely understood. Here we show that truncated APP C586-695 fragment generated by δ-secretase directly binds to CCAAT/enhancer-binding protein beta (CEBPB), an inflammatory transcription factor, and enhances its transcriptional activity, escalating Alzheimer’s disease-related gene expression and pathogenesis. The APP C586-695 fragment, but not full-length APP, strongly associates with CEBPB and elicits its nuclear translocation and augments the transcriptional activities on APP itself, MAPT (microtubule-associated protein tau), δ-secretase and inflammatory cytokine mRNA expression, finally triggering Alzheimer’s disease pathology and cognitive disorder in a viral overexpression mouse model. Blockade of δ-secretase cleavage of APP by mutating the cleavage sites reduces its stimulatory effect on CEBPB, alleviating amyloid pathology and cognitive dysfunctions. Clearance of APP C586-695 from 5xFAD mice by antibody administration mitigates Alzheimer’s disease pathologies and restores cognitive functions. Thus, in addition to the sequestration of amyloid-β, APP implicates in Alzheimer’s disease pathology by activating CEBPB upon δ-secretase cleavage.