bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análise da devolução de medicamentos à farmácia em um hospital de alta complexidade no Rio de Janeiro
Authors: PASSOS João Victor , MATOS Julia Talarico , FREITAS Andressa Florêncio , BRASIL Juliana Castro , PEREIRA Camili Gomes , CABRAL Dominique Souza , PORTO Daniele Ferreira 
Published: December 2024

Objetivo: Analisar o perfil e os custos relacionados às devoluções de medicamentos à farmácia hospitalar de grande porte. Métodos: Estudo de caráter retrospectivo observacional de coleta mensal dos dados das devoluções de medicamentos, por meio de preenchimento de planilhas conforme o recebimento das devoluções no período de junho de 2023 a maio de 2024. Os medicamentos que, por diversos motivos, não foram incorporados ao estoque, foram compilados com o auxílio do software Microsoft Excel® e classificados de acordo com a forma farmacêutica, classe farmacológica, quantidade e valor unitário. A partir daí foram conduzidas análises sobre o impacto financeiro dessas perdas para o hospital. Resultados: Do valor médio de US$7170,88 em medicamentos devolvidos à farmácia hospitalar mensalmente, US$507,73 foram em perdas, ou seja, não puderam ser reintroduzidos ao estoque, enquanto o alto valor de itens reaproveitados demonstra a importância do monitoramento do processo de devolução. Além disso, observou-se que a maior parte dos medicamentos reintroduzidos ao estoque pertencem à classe dos antimicrobianos. Embora essa prática tenha proporcionado benefícios financeiros à instituição, devido ao alto custo desses medicamentos, ela levanta uma importante questão sobre possíveis falhas no tratamento. A devolução dos antimicrobianos pode estar relacionada a erros de prescrição, alterações no estado clínico do paciente e diagnósticos incorretos. Com isso, esses fatores contribuem significativamente para a não administração dos medicamentos e, consequentemente, para sua devolução ao estoque. Conclusão: Os resultados obtidos mostram a importância de aprimorar o processo de devolução no hospital visando evitar perdas e aumentar a segurança do uso de medicamentos pelos pacientes.
Anamnestic and anthropometric features in children and adolescents with different variants of papillary thyroid cancer
Authors: Hryshchenko K. V. , Tovkai O. A. , Yuzvenko T. Y. , Belemets N. I. , Kuts V. V. , Voitenko V. V. 
Published: December 2024

Objective — to analyze the anamnestic and anthropometric data of the preoperative examination of patients with different variants of papillary thyroid cancer (PTC).
Materials and methods. A retrospective analysis of the medical records of 106 patients with PTC aged 4 to 18 years operated on at the Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine was performed. We analyzed family history data (presence of thyroid pathology and cancer in close relatives), history of thyroid pathology, presence of concomitant oncological pathology and types of its treatment, and anthropometric parameters (BMI).
Results. When analyzing age characteristics, no statistically significant difference was found in the frequency of variants of PTC in different age groups (p >0.05). We also did not find a statistically significant difference between the study groups regarding family history and the presence of oncology in patients in the past (p >0.05). Among the preoperative characteristics, patients in the MF group, in contrast to the MonoF group, had a significantly higher frequency of autoimmune thyroiditis (AIT) (p <0.05).
Conclusions. Age, a burdened family history, including the presence of benign thyroid pathology, a history of oncology and BMI are not reliable prognostic factors for the spread of PTC in the thyroid parenchyma. Patients with AIT require careful monitoring for the potential development of PTC, in particular MF and DSV.
Thoracoscopic parathyroidectomy: a 22-year experience
Authors: Buzanakov D. , Alesina P. F. , Kniazeva P. , Walz M. K. 
Published: December 2024

Thoracoscopic parathyroidectomy (TP) is a preferred approach to the treatment of hyperparathyroidism (HPT), caused by hyperfunctioning parathyroid glands located in mediastinum, though the data on its feasibility and safety are scarce, due to the rarity of this condition.
Objective — to assess the safety and feasibility of thoracoscopic parathyroidectomy.
Materials and methods. A retrospective cohort included 25 patients (14 male, 11 female) of primary thoracoscopic parathyroidectomy performed in Kliniken Essen‑Mitte and Wuppertal Helios Hospital from August 2002 to December 2024. Out of the patients included in the study, 15 patients underwent TP as their initial operation for primary HPT (pHPT), 7 patients had persistent pHPT after cervical operations, one — recurrent pHPT, and two — recurrent secondary HPT. Median age was 60 years (range: 27—77 years). The mediastinal location of the parathyroid was suspected by (99m)Tc‑sestamibi (MIBI)‑scintigraphy in 18 cases, five cases were MIBI‑negative, and in two cases, no MIBI‑scintigraphy was performed. In all cases, parathyroid localization was confirmed by 4D Computed tomography (CT) scan (n=17), magnetic resonance imaging (MRI) (n=3) or Positron emission tomography (PET‑CT) (n=5). Pre‑ and postoperative levels of serum calcium and parathormone, histopathological reports, and surgery protocols were analyzed. Intraoperative parathyroid hormone (PTH) level was measured with a rapid assay to confirm the success of the procedure 15 minutes after resection.
Results. During the investigated period, 26 thoracoscopic operations were performed. Overall success rate was 84.6% as in 4 cases no hyperfunctioning parathyroid tissue was thoracoscopically removed. In the first case, a cervical approach was required; in the second one, the patient was reoperated thoracoscopically one year later; in the third case, the operation resulted in the normalization of serum calcium level despite the absence of parathyroid tissue in the pathological specimen. In one more case, the patient demonstrated postoperatively elevated PTH level with normal serum calcium level. Median duration of operations was 80 minutes (range: 20—320 minutes). No perioperative deaths or major complications occurred. No conversion to sternotomy or thoracotomy was performed. A complication rate was 4.2%, including one case of chylothorax, followed by a successful retroperitoneoscopic ligation of the thoracic lymphatic duct, and one case of temporary phrenic palsy. Median postoperative hospital stay was 2 days (range 2—6 days). No readmissions due to any reasons after discharge were registered.
Conclusions. Thoracoscopic parathyroidectomy is safe and feasible, being the optimal treatment option in most cases of mediastinal parathyroid adenomas. However, it requires precise preoperative localization to guarantee the success of the treatment.
Changes in some biochemical indicators in psoriasis patients as a marker of disease activity
Authors: Syzon O.O. , Dashko M.O. , Ceshaplyk­–Chyzho I.O. 
Published: December 2024

The elicitation of primary nature of biochemical shifts occurred at psoriatic disease and the prediction of interconnected subsequent changes in metabolic and inflammatory processes are important in predicting the dynamic development of pathological process and the choice of individual treatment.
Objective — to assess disorders and correlations between main indicators of protein, fat, hydrocarbon and pigment metabolism and specifics of inflammatory processes in psoriatic patients against the clinical course of dermatosis.
Materials and methods. We have analysed the results of clinical and laboratory examinations performed in respect of 62 psoriatic patients. All these patients have been analysed per their age, sex, prevalence and the type of skin rash as well as per the clinical disease form. Biochemical examinations have been conducted using appropriate sets of reagents. To establish the possible correlation between the indicators of biochemical blood analysis, we have calculated the correlation coefficient, which determines the nature of correlation between the studied variables.
Results and discussion. The analysis of results received upon examining psoriatic patients indicated that microbial-viral associations, stress factors and genetic predisposition were the most frequent trigger factors of psoriatic disease, which corresponds to the data from literary sources. We have registered that the psoriaric disease of duration up to 5 years was the most common, and relapses manifested in its limited form against the background of the disease advanced stage; the prevalent psoriasis was more common for the hospital stage. Our study justifies that metabolic changes occurred in the overwhelming majority of examined patients of different age groups. At that, abnormalities of a number of indicators of protein, lipid, hydrocarbon and enzyme metabolism have been established. In addition, the expressiveness of corresponding changes correlated with the prevalence of skin psoriatic process and the duration of dermatosis course as well as the presence of pathology of a number of internal organs, in particular of gastrointestinal tract, hepatobiliary and cardiovascular systems, that suggest the presence of systemic disorders at psoriasis.
Conclusions. The establishment of independent mechanisms existing between some changes in metabolic process parameters at psoriasis has a theoretical and practical significance in dermatology, which involves the use of medications to regulate the established disorders, the possibility to restore correlations as it will inevitably contribute to the achievement of clinical and preventive effect.
Studi Etnofarmakognosi Dan Etnomedisin Masyarakat Lereng Selatan Gunung Slamet Kabupaten Banyumas Jawa Tengah
Authors: Rachmani Eka Prasasti Nur , Suhesti Tuti Sri 
Published: December 2024

Salah satu pemanfaatan tanaman yaitu untuk tujuan pengobatan. Pemanfaatan tanaman untuk pengobatan berdasarkan pengalaman turun-temurun yang bersifat lisan, rentan terjadi kesalahan informasi. Penelitian ini bertujuan untuk mendokumentasikan pemanfaatan tanaman obat berdasarkan pengetahuan dan kearifan lokal masyarakat di lereng selatan Gunung Slamet yang meliputi Kecamatan Baturraden, Kedungbanteng, Sumbang dan Purwokerto Utara. Penelitian dilakukan dengan menggunakan pendekatan kualitatif dan kuantitatif. Metode penelitian dilakukan dengan wawancara dan observasi yang melibatkan informan yang memiliki kriteria pelaku dan pengobat tradisional. Data profil informan dianalisis secara deskriptif. Analisis kuantitatif meliputi penetapan nilai dan pentingnya tanaman bagi masyarakat dilakukan secara kuantitatif dengan menghitung nilai guna tanaman untuk pengobatan (Use Value/UV), nilai guna famili (Family Use Value/FUV), frekuensi kutipan relatif (Relative Frekuensi Citation/RFC), tingkat fidelitas (Fidelity Level/FL) serta data mengenai bagian tanaman, cara penyiapan, dan cara penggunaan tanaman. Hasil penelitian menunjukkan bahwa 12 responden menyebutkan 56 jenis tumbuhan yang termasuk dalam 27 famili. Famili yang paling banyak digunakan berdasarkan nilai FUV adalah zingiberaceae, terdapat 9 spesies yang memiliki 17 kegunaan (khasiat). Tanaman yang paling penting untuk pengobatan berdasarkan nilai RFC tertinggi berturut-turut yaitu kunyit (1,00), jahe (0,92), dan temulawak (0,92). Terdapat 13 jenis tanaman yang memiliki nilai FL 100% yang terdapat dalam famili acanthaceae, araliaceae, asteraceae, campanuiaceae, cupresaceae, euphorbiaceae, fabaceae, liliaceae, myrtaceae, dan zingiberaceae. Hal ini menunjukkan bahwa tanaman tersebut sangat dipercaya untuk tujuan pengobatan tertentu. Bagian tanaman yang paling sering digunakan adalah daun (39%), cara penyiapan bahan tanaman untuk obat yang paling sering dilakukan adalah direbus (56%), cara penggunaan yang sering dilakukan adalah secara per oral (69%) dan sebagian besar bahan tanaman yang digunakan adalah bahan segar (91%). Temuan ini menguatkan data bahwa tanaman pada famili zingiberaceae merupakan tanaman utama yang banyak digunakan untuk pengobatan pada masyarakat lereng selatan Gunung Slamet.
Effect of Crushed Concrete on Some Properties of Modified Reactive Powder Concrete Reinforced With Micro Steel Fibers
Authors: Saeed Rusul Hussain , Fawzi Nada Mahdi 
Published: December 2024

Conventional RPC does not contain coarse content aggregate, but some researchers incorporate coarse aggregate. Those researchers used coarse aggregate to produce RPC, the new RPC known as modified reactive powder concrete (MRPC). This paper shows the findings of a study that looked into using crushed concrete as aggregates. The crushed concrete was taken from examined cube spacemen of a road project in the city of Baghdad and then crushed until they were no bigger than 10 mm. Micro steel fibres (1% by volume of the concrete) and crushed concrete (25% and 100%) of the original reactive powder concrete were added to the mix instead of fine sand and micro steel fibres before the casting. Look into several properties of the standard and reactive powder concrete, including their density, compressive Strength and flexural Strength. Compressive Strength of modified reactive powder concrete with 25% crushed concrete increased by 16.86% and 10.57 and slightly increasing by 4.81% Moreover, 3.84% at age 7 days and 28 days of testing, respectively, when 100% crushed concrete was used instead of sand when compared with the reference mixture. When 25% crushed concrete was incorporated, Flexural Strength increased by 44.33% and 29.85 and when 100% crushed concrete was incorporated, Flexural Strength decreased by 14.15% and 12.68%% at age 7 days and 28 days, respectively, when compared with the reference mixture
Design and Implementation of the Attitude, Ethics and Communication Module -Working in a Healthcare Team in a Medical Institute
Authors: Shetty Archana , Sandeepa Surpiya , Minal Jessica , Murali Nirupama 
Published: December 2024

Background Communication and inter-personal skills are an imperative requirement in undergraduate medical curriculum. Incorporation of Attitude, Ethics and Communication module (AETCOM) was a major change in the new curriculum implemented by National Medical Commission (NMC) of India in 2019. Implementing modules related to soft skills like “Working in a healthcare team” come with challenges and novel learning experiences for the medical faculties.MethodsThis prospective cross-sectional study was conducted in the department of Pathology at a medical college institute over a period of four months. AETCOM module “Working in a healthcare team” was to be taken over a duration of six hours on every Saturday 8:00 to 9:00 am consecutively for six weeks. Two hours were taken as small group discussions and four hours as class room based planned interview sessions with under recognized personnel of healthcare team – billing, housekeeping staff, junior residents, and techniciansResultsA brief outline of the entire module was conveyed in the first small group session. Subsequent interview sessions were divided into icebreaking, interview and concluding sessions. In the last small group session, students were asked to give feedback and write the narrative reflective writing in their log books as a formative assessment. The students liked interview session of housekeeping personnel the most.Conclusions We wish to share our experience of designing and implementing this module which not only gave students a preview into contribution of various personnel in daily patient care but also stressed upon the need for developing an attitude of respect and good communication.
Assessment of cardiorespiratory fitness in medical students using the Queen’s College Step Test: A gender-based analysis of VO2max
Authors: Prajapati Rajesh , Amatya Neebha , Shrestha Ripti , Rana Magar Rajab , Amatya Mrigendra 
Published: December 2024

Introduction: VO2max, a measure of the maximum oxygen uptake during physical exertion, is a critical indicator of cardiovascular fitness. Evaluating VO2max in young adults helps in understanding their fitness levels and guiding improvements. This study aimed to assess normal VO2max levels and investigate the relationships between oxygen saturation (SpO2) and VO2max, as well as between blood pressure and VO2max, in both male and female participants.
Methods: A total of 93 students (45 males, 48 females) aged 18 to 25 years from Gandaki Medical College, Pokhara, were selected through simple random sampling. VO2max was estimated using the Queen’s College Step Test (QCT), a widely accepted indirect method to assess cardiorespiratory fitness. QCT provides a convenient way to evaluate maximum oxygen uptake in a non-laboratory setting.
Results: The mean VO2max for male participants was 62.00±8.77 ml/kg/min, while for females, it was 41.79±3.18 ml/kg/min. Males exhibited significantly higher VO2max values compared to females (p<0.001). Both diastolic blood pressure (p = 0.013) and SpO2 (p < 0.001) were found to have a significant influence on VO2max in female but not changed in the male.
Conclusions: This study confirms that gender-related differences in cardiovascular fitness exist, with males generally showing higher endurance levels compared to females. The lower VO2max values observed in females were primarily associated with variations in SpO2 and diastolic blood pressure. These findings highlight the importance of considering physiological variables such as oxygen saturation and blood pressure in the assessment of female cardiorespiratory fitness.
विद्यालय तहमा निबन्ध शिक्षणका विधि र प्रक्रियाको उपयोग
Authors: पन्थ Pantha नारायणप्रसाद Narayan Prasad 
Published: December 2024

प्रस्तुत लेखको उद्देश्य निबन्ध शिक्षणका विधि र प्रक्रिया उपयोगको पहिचान तथा विश्लेषण गर्नु रहेको छ । गुणात्मक अनुसन्धान पद्धतिमा आधारित यस लेखमा रुपन्देही जिल्लाका पाँचओटा विद्यालयमा नेपाली अध्यापन गर्ने दसजना शिक्षक छनोट गरी अर्धसंरचनात्मक प्रश्नावलीका आधारमा तथ्य सङ्कलन गरिएको छ । यस लेखमा द्वितीयक स्रोतका रूपमा पुस्तकालयीय कार्यबाट सैद्धान्तिक सामग्री सङ्कलन गरी उक्त तथ्यहरूको विश्लेषण गरिएको छ । शिक्षकका धारणा अनुसार निबन्धलाई भाषाशिक्षण सिकाइसँग जोड्नुपर्दछ । विद्यार्थीका शैक्षिक तथा मनोवैज्ञानिक स्तरअनुसार समयसापेक्ष रूपमा निबन्धका पाठ्यवस्तु छनोट र स्तरण गर्नुपर्ने देखिन्छ । निबन्ध शिक्षणबाट शब्दभण्डारमा वृद्धि, मौलिक तथा सिर्जनात्मक अभिव्यक्ति, पठनबोध क्षमता, शब्द प्रयोगगत विशिष्टता, विचारको प्रस्तुतीकरण,सङ्गठन, वाक्यगठन तथा अनुच्छेद गठनगत सिपको विकास गराउन सकिने भएकाले शिक्षणका क्रममा व्याख्या, छलफल, प्रश्नोत्तर, तुलना, समीक्षा, प्रतिवेदन प्रस्तुति, परियोजना, पठनबोधतथा कक्षा प्रस्तुतीकरण विधिको उपयोग गर्दै कक्षाको परिस्थिति, निबन्धको गहनता तथा विद्यार्थीका कक्षागत स्तरलाई दृष्टिगत गरी एक वा बढी शिक्षण विधिहरू अँगालिएको निचोड निकालिएको छ । यो अध्ययन यस क्षेत्रमा रही अन्वेषण गर्न चाहने विद्यार्थी, शिक्षक तथा अनुसन्धानकर्ता लगायतलाई सैद्धान्तिक अवधारणा ग्रहण गर्न र त्यसको उपयोग गरी प्रयोगपरक विश्लेषण गर्न मद्दत पुग्ने अपेक्षा गरिएको छ ।
Religious and Economic Contributions of Sayyid Hadhrami in Palembang During the 18<sup>th</sup> – 21<sup>st</sup> Centuries
Authors: Syukri Ahmad , Mohammad Nabil Almunawar  , Mohammad Nabil Almunawar  
Published: December 2024

As the oldest cosmopolitan city in Indonesia, Palembang has a diverse range of ethnic groups that interact on political, economic, and religious levels. Among these groups, the Sayyid Hadhrami community, descendants of the Prophet Muhammad who came from Hadramawt, South Yemen, actively preached Islam and engaged in trade in Palembang from the mid-18th century. While numerous studies have explored the Sayyid Hadrami's activities on the island of Java, few have focused on their role in Palembang. This article examines the political, economic, and religious of Sayyid Hadhrami in Palembang from the 18th to the 21st centuries. The study employs qualitative research using a historical approach. This study found that during the 18th – 19th centuries, the Sayyid Hadhrami served as clerics for Palembang propagators of Islam and intermediaries of Indian Ocean trade. Following the collapse of the Palembang sultanate in the 20th - 21st centuries, the Hadhrami community established their own religious regime. Central to their identity is their role in propagating Islam and their affiliation with the Tarekat Alawiyah, a Sufi Order originating from the Hadhrami Sayyids. Religious traditions in the Tarekat Alawiyah include Ziarah, Mawlid, and Haul. The Sayyid Hadhrami in Palembang Sucessfully transformed trade capital into religious capital to maintain their religious authority.
State regulation of health care: principles, mechanism and tools
Authors: РЯБЕЦЬ Д. М. 
Published: December 2024

The aim of the study. The purpose of the article is to study the principles, mechanisms and tools of state regulation of health care, which form the basis for the development of practical recommendations for its improvement. Methodology. General scientific methods are used in the research, in particular: theoretical generalization – to determine the theoretical foundations and trends of the content and constituent principles, the mechanism of regulation of health care; system approach – to generalize the classification of instruments of state regulation of health care; methods of positive and normative analysis – to develop recommendations for improving the mechanism of regulation of health care. Results. The improvement of the mechanism of regulation of the health care system as the main component of the competitiveness of the national economy and the formative vector of quality of life of the population is substantiated. It is proposed to consider three components of mechanisms: organizational-administrative, socio-economic, institutional and legal. The organizational and administrative mechanism is proposed to take into account the development of a strategy for decentralization of management and autonomy of health care institutions, as they are associated with the formation of so-called targeted regulated markets, combined with models of mandatory selfregulation and decentralization. and intersectoral cooperation; coherence of central and local public authorities and other legal entities in the implementation of health policy, defining the powers and relationships between the entities. The socio-economic mechanism must include the improvement of social insurance regulation tools, development of strategy and policy of the medical institution, recognition of budget funding and development of voluntary health insurance, improvement of the system of paid medical services, financial resources for training and retraining, introduction of new technologies in the field of health care; evaluation of results with the use of modern information and communication technologies (monitoring); close interaction with patients and involvement in the management of public control. The institutional and legal mechanism determines the improvement of health care legislation governing the content and process of state and legal regulation of health care (improvement in determining the priority of state budget expenditures, state control, tax system, standards, customs tariffs,); development plan development. The principles and tools of state regulation of health care are presented. The classification of instruments of state regulation of health care is divided into methods of direct and indirect influence. Practical meaning. Improving the mechanisms of state regulation of health care to modern economic conditions. Prospects for further research. Studies of the principles of state regulation of health care provide grounds for further improvement of the tools, which will be devoted to further research by the author.