bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Outcome of High Tibial Osteotomy in Patients with Medial Compartment Osteoarthritis Using Dynamic Axial Fixator
Authors: Yadav Amit kumar , Parihar Mangal , Gawhale Sangeet 
Published: July 2021

Objectives: Medial Compartment Osteoarthritis of the knee is becoming a widespread problem. The surgical options include high tibial osteotomy, unicompartmental knee replacement, and total knee replacement. Replacement surgeries are not advised in the younger age group, so in these patients, high tibial osteotomy is the only option. In this study, we have assessed the functional and radiological outcomes of high tibial osteotomy done by hemicallostasis method. Methods: We report the outcome of 30 patients (30 knees) who underwent hemicallostasis with a dynamic external fixator for medial compartment osteoarthritis of the knee. The radiological assessment was done with the help of Hip Knee Ankle angle. The functional scoring was done via Oxford knee score, IKDC, KOOS, and WOMAC score. Results: At a mean follow up of 35 months, the preoperatively mean HKA angle was 172 ± 30. The mean HKA angle postoperatively was 184 ±10. Appropriate correction of the HKA angle was achieved in 24 of 30 patients (80%). Whereas, there was under correction in 3 patients (10 %) and overcorrection in 3 (10%) patients. All the functional scores showed significant improvement in the postoperative scores. There was a positive correlation between the HKA angle and oxford, IKDC, KOOS, and WOMAC Score. Complications like superficial pin tract infection were seen in 3(10 %) patients, deep infection in 1(3%), and early union of osteotomy in 1 (3%) patient leading to re-osteotomy. Conclusion: HTO is effective in improving pain, function, activity of daily living, and quality of life in patients suffering from medial compartment Osteoarthritis of the knee. Hip Knee Ankle Angle is an important parameter to restore for better functional outcomes. The Advantage of using a dynamic axial fixator is the precision in achieving calculated correction without any implant in the bone once the correction is achieved along with good healing rates.
Measuring Appropriate Need for Unicompartmental Knee Arthroplasty: Results of the MANUKA study
Authors: Klasan A , Luger M , Hochgatterer R , Young SW 
Published: July 2021

Purpose: Indications for unicompartmental knee arthroplasty (UKA) are controversial. Studies based solely on radiographic criteria suggest up to 49% of patients with knee osteoarthritis (OA) are suitable for UKA. In contrast, the ‘Appropriate use criteria’ (AUC), developed by the AAOS, apply clinical and radiographic criteria to guide surgical treatment of knee OA. The aim of this study was to analyse patient suitability for TKA, UKA and osteotomy using both radiographic criteria and AUC in a cohort of 300 consecutive knee OA patients. Methods: Included were consecutive patients with clinical and radiographic signs of knee OA referred to a specialist clinic. We collected demographic data, radiographic wear patterns and clinical findings that were analyzed using the AUC. We compared the radiographic wear patterns with the treatment suggested by the AUC as well as the Surgeon Treatment Decision. Results: There were 397 knees in 300 patients available for analysis. Median age was 68 [IQR 15], BMI 30 [6] with 55% females. We found excellent consistency for both the radiographic criteria and the AUC criteria. Based on radiological criteria, 41% of knees were suitable for UKA. However, when using the AUC criteria, UKA was the appropriate treatment in only 13.3% of knees. In 19.1% of knees, no surgical treatment was appropriate at the visit, based on the collected data. Conclusion: Application of isolated radiologic criteria in patients with knee OA results in a UKA candidacy is misleadingly high. AUC that are based on both radiological and clinical criteria suggest UKA is appropriate in less than 15% of patients.
Injuries of Kaplan fibers in ACL deficient and reconstructed knees – redefining the structure and risk assessment on MRI using injury patterns
Authors: Iordache Edna A. , Hirschmann Michael T. , Amsler Felix , Yang Schu-Ren , Hess Silvan , Hirschmann Anna 
Published: July 2021

Objectives: To determine an injury pattern of knee structures along torn Kaplan fibers in ACL deficient knees and to observe the healing process of Kaplan fibers in ACL reconstructed knees. Methods: A total of 101 knee MRIs obtained between January 2004 and April 2020 with full-thickness ACL tears were retrospectively assessed for visibility and impairment of three Kaplan bundles (proximal, distal and epicondylar band) and for associated injuries by two fellowship-trained independent musculoskeletal radiologists. A subgroup of 33 follow-up knee MRIs after ACL reconstruction was assessed to observe the natural evolution of Kaplan fibers injury. Descriptive statistics and Spearman correlation coefficients (P<.05) were used to determine injury patterns. Results: Kaplan fibers were injured in 43 of 101 (43%) acute ACL deficient knees. Proximal Kaplan fibers were visible in less than 48 of 101 (50%) knees as opposed to the distal Kaplan fibers and epicondylar Kaplan band which were both visible in 98 of 101 (97%) knees. Injury to the Kaplan complex was significantly associated with anterolateral (rho, 0.36; P<.001) and lateral collateral ligament impairment (rho, 0.21;P<.05) and medial femoral bone marrow edema (rho, 0.21;P<.05). After ACL reconstruction, only two of 33 (6%) patients showed torn Kaplan and 13 of 33 (39%) distal Kaplan fibers were scarred. Conclusion: Torn Kaplan fibers are associated with anterolateral and lateral collateral ligament injuries in ACL deficiency, indicating a more severe anterolateral and rotatory instability. Injury patterns in ACL deficient knees can eliminate the uncertainty of proximal Kaplan fibers identification. Kaplan fiber tears tend to heal following ACL reconstruction.
Patients’ satisfaction after total knee arthroplasty: Tashkent Medical Academy experience
Authors: Madrakhimov Sarvar , Karimov Murodulla 
Published: July 2021

Objectives: The aim of the study was to assess satisfaction of our patients after primary total knee arthroplasty (TKA) at various intervals of follow-up. Methods: This prospective study was performed in the Multidisciplinary clinic of the Tashkent Medical Academy in the Department of orthopedics from November 2018 to October 2020 performed 88 unilateral TKAs in patients with confirmed diagnosis of primary knee osteoarthritis III-IV grade (Kellgrene-Lawrence, 1978). Among them, 32 males and 54 females aged from 56 to 83 years old with an average of 65.1 years old. The follow up period ranged from 1 month to 1 year. On each follow-up examination (3, 6, 12 month period), every patient received UCLA activity score and VAS score. The patients assessed the degree of satisfaction after TKA on a scale ranging from "fully satisfied" to "dissatisfied" and expressed their overall satisfaction in percent. Results: The mean length of stay in the obese group was 11.3 days (±6.3). There were no 30-day re-admisison cases. At the final follow-up, 4.54% of the patients were not satisfied with the outcome. Of 56 patients (63.6%) who were working before TKA, 42 (75%) returned to any job at a mean of 12 weeks post-operatively. Mean UCLA scores improved in 61 patients (69%) from 4 (mild activity) to 6 (moderate activity). The patients’ overall satisfaction was 82.2 % (i.e., responses to the question of how you were satisfied with surgery). Significantly, more satisfied patients were among those with primary osteoarthritis without any fixed deformities. Their satisfaction was related to the level of the UCLA activity rating. However, there was slight relation between VAS-evaluated pain intensity before TKA and patient satisfaction after arthroplasty. Conclusion: An analysis of patient responses shows that the level of satisfaction is high in the short period after surgery. Overall, patient satisfaction is slightly changed approximately 12 months after surgery. The number of dissatisfied patients or those who reported regular pain after TKA in our study is consistent with the results presented in the relevant literature, number of patients could be the cause of this. Furthermore, preoperative discussion of functional properties after TKA could help reduce dissatisfaction after TKA. In addition, multicenter studies are needed for a more in-depth analysis of patient satisfaction after TKA.
Impact of Wearing Dentures on Dietary Intake, Nutritional Status, and Eating: A Systematic Review
Authors: Moynihan P. , Varghese R. 
Published: July 2021

Introduction: A key purpose of denture provision is to enable eating, yet the body of evidence pertaining to the impact of dentures on wide-ranging nutritional outcomes has not been systematically reviewed. Objectives: To systematically review published evidence pertaining to the effect of wearing removable dental prosthesis on dietary intake, nutritional status, eating function, and eating related–quality of life (ERQoL). Methods: Eight questions relating to the impact of wearing dentures on nutritional outcomes were addressed. The target population was healthy adults aged ≥18 y. Data sources included Medline, Embase, CINAHL, and PubMed. Included were all human epidemiologic studies. The Newcastle-Ottawa score was used for appraisal of study quality. Harvest plots, vote counting, and accompanying narrative provided the basis for synthesis. Results: Of the 1,245 records identified, 134 were retrieved and eligibility assessed by 2 reviewers, and 41 studies were included in the synthesis (14 rated good quality, 20 fair, and 7 poor). The balance of data supported a positive impact of wearing full (5/7 studies) or partial (3/3 studies) dentures (vs. no dentures) on nutritional status, though no clear direction of effect was detected for the impact of dentures on dietary intake. The balance of data clearly showed that objective measures of eating function were compromised in full (14/15 studies) and partial (6/7 studies) denture wearers as compared with the dentate. Data showed that ERQoL was also compromised in denture wearers as compared with the dentate (3/3 studies). However, data showed a positive impact of wearing dentures on ERQoL (5/5 studies) as opposed to wearing no dentures. Conclusion: The balance of evidence shows that despite no clear pattern on impact of wearing dentures on measured dietary intake, in those with tooth loss, wearing dentures can have a positive impact on nutritional status and enjoyment of eating. Knowledge Transfer Statement: The results of this systematic review can be used to advocate for health care services to address prosthodontic need to benefit nutritional outcomes. The findings will be of use in educating health care professionals on the impact of wearing dentures and not addressing prosthodontic need on nutritional outcomes.
Patient Roadmaps for Chronic Illness: Introducing a New Approach for Fostering Patient-Centered Care
Authors: Scherer Laura D. , Matlock Daniel D. , Allen Larry A. , Knoepke Chris E. , McIlvennan Colleen K. , Fitzgerald Monica D. , Kini Vinay , Tate Channing E. , Lin Grace , Lum Hillary D. 
Published: July 2021

Background. Too frequently, patients with chronic illnesses are surprised by disease-related changes and are unprepared to make decisions based on their values. Many patients are not activated and do not see a role for themselves in decision making, which is a key barrier to shared decision making and patient-centered care. Patient decision aids can educate and activate patients at the time of key decisions, and yet, for patients diagnosed with chronic illness, it would be advantageous to activate patients in advance of critical decisions. In this article, we describe and formalize the concept of the Patient Roadmap, a novel approach for promoting patient-centered care that aims to activate patients earlier in the care trajectory and provide them with anticipatory guidance. Methods. We first identify the gap that the Patient Roadmap fills, and describe theory underlying its approach. Then we describe what information a Patient Roadmap might include. Examples are provided, as well as a review comparing the Patient Roadmap concept to existing tools that aim to promote patient-centered care (e.g., patient decision aids). Results and Conclusions. New approaches for promoting patient-centered care are needed. This article provides an introduction and overview of the Patient Roadmap concept for promoting patient-centered care in the context of chronic illness. [Box: see text]
Maximizing Muscle Function in Cuff-Deficient Shoulders: A Rehabilitation Proposal for Reverse Arthroplasty
Authors: Razmjou Helen , Osnabrugge Varda van , Anunciacion Mark , Nunn Andrea , Drosdowech Darren , Roszkowski Ania , Szafirowicz Analia , Boljanovic Dragana , Wainwright Amy , Nam Diane 
Published: July 2021

Purpose The purpose of this review is to describe the role of altered joint biomechanics in reverse shoulder arthroplasty and to propose a rehabilitation protocol for a cuff-deficient glenohumeral joint based on the current evidence. Methods and Materials: The proposed rehabilitation incorporates the principles of pertinent muscle loading while considering risk factors and surgical complications. Results In light of altered function of shoulder muscles in reverse arthroplasty, scapular plane abduction should be more often utilized as it better activates deltoid, teres minor, upper trapezius, and serratus anterior. Given the absence of supraspinatus and infraspinatus and reduction of external rotation moment arm of the deltoid in reverse arthroplasty, significant recovery of external rotation may not occur, although an intact teres minor may assist external rotation in the elevated position. Conclusion Improving the efficiency of deltoid function before and after reverse shoulder arthroplasty is a key factor in the rehabilitation of the cuff deficient shoulders. Performing exercises in scapular plane and higher abduction angles activates deltoid and other important muscles more efficiently and optimizes surgical outcomes.
Clinicopathologic and Immunohistochemical Characteristics of Solitary Fibrous Tumor and Its Mimics: A Single-Center Experience
Authors: Geramizadeh Bita , Safavi Fatemeh 
Published: July 2021

Background: Solitary fibrous tumor (SFT) is a fibroblastic tumor that has been originally reported as a pleural tumor but now has been defined as a tumor that can be seen everywhere in the human body. Histopathologically, many of the fibroblastic tumors can mimic SFT, and immunohistochemistry is necessary for differential diagnosis. Several markers have been used, and recently, STAT6 has been introduced as a diagnostic marker. No research study has been reported from Iran. Objectives: In this report, we are trying to introduce our experience about the clinicopathologic findings of 35 cases of SFT during the last 10 years from our center with an emphasis on the diagnostic role of STAT6 in this tumor. Patients and methods: During the last 10 years, we confirmed the diagnosis of 35 cases of SFT in the pathology archives of Shiraz University of Medical Sciences. These 35 cases were considered as cases. All the clinicopathologic findings were also extracted from the clinical charts of the patients. To evaluate the diagnostic role of STAT6, another 35 cases of spindle cell tumors were also extracted from the pathology archives as mimickers of SFT. STAT6 was stained in all of the 70 cases and controls. Results and discussion: Our experience showed that SFT is more common in middle-aged men with a wide age range, although it is very rare in children. It can be present in every location with a wide size range from less than 1 cm to more than 15 cm. The presence of abnormal staghorn vessels is one of the main diagnostic histopathologic characteristics. STAT6 showed a sensitivity and specificity of 91% and 86% in the diagnosis of SFT. Other markers such as CD99, CD34, and BCL2 have also been considered useful in the differential diagnosis of this tumor, although the diagnostic accuracy seems to be lower than STAT6. High mitosis, presence of necrosis, and atypia are important criteria for predicting malignant and aggressive behavior in SFT. Among 35 cases in our study, 17% showed malignant behavior as recurrent or metastatic tumors. Conclusion: Solitary fibrous tumor is a common soft tissue tumor that can be seen everywhere and needs careful histopathologic and immunohistochemical evaluation for the correct diagnosis and prediction of aggressive or benign behavior.
The economic assessment of the environmental and social impacts generated by a light packaging and bulky waste sorting and treatment facility in Spain: a circular economy example
Authors: Medina-Mijangos Rubí , Ajour El Zein Samer , Guerrero-García-Rojas Hilda , Seguí-Amórtegui Luis 
Published: July 2021

Abstract
Background
The waste sorting and treatment facilities play an important role in the management of Municipal Solid Waste (MSW), as they permit the materials to be prepared for their later reuse and recycling. The aim of this work is to carry out a technical–economic analysis of a sorting and treatment facility (STF) of light packaging and bulky waste in Gavà-Viladecans, Barcelona, Spain, by means of a methodology based on a social Cost–Benefit Analysis (sCBA), as it studies the private impacts and externalities (impacts related with environmental and social aspects) to determine the Total Benefit (the difference between revenues and costs) generated by the facility to decide whether it is operationally and economically profitable.

Results
The key point of the case study is the identification, frequency, quantification and monetary valuation of the impacts generated by the facility, as well as the sale of materials, the CO2 emissions and the increase in the availability of materials, among others. By applying the methodology, it has been possible to show that this facility is operationally (BP = 7.06 €/ton) as well as economically (BT = 55.72 €/ton) profitable.

Conclusions
The plant is highly profitable from a social and environmental perspective, as can be seen from the monetary valuation of the externalities. The STF fulfils a primordial function for the city of Barcelona and its environs, as it treats waste for later reuse and recycling, preventing waste from being sent to landfills and reducing the CO2 emissions from the extraction of virgin raw materials, thereby helping to reach the objectives set by the European Commission. Finally, this paper provides a guide for future researchers and decision makers interested in the economic analysis of MSW management systems.
ANMDA: anti-noise based computational model for predicting potential miRNA-disease associations
Authors: Chen Xue-Jun , Hua Xin-Yun , Jiang Zhen-Ran 
Published: July 2021

Abstract
Background
A growing proportion of research has proved that microRNAs (miRNAs) can regulate the function of target genes and have close relations with various diseases. Developing computational methods to exploit more potential miRNA-disease associations can provide clues for further functional research.

Results
Inspired by the work of predecessors, we discover that the noise hiding in the data can affect the prediction performance and then propose an anti-noise algorithm (ANMDA) to predict potential miRNA-disease associations. Firstly, we calculate the similarity in miRNAs and diseases to construct features and obtain positive samples according to the Human MicroRNA Disease Database version 2.0 (HMDD v2.0). Then, we apply k-means on the undetected miRNA-disease associations and sample the negative examples equally from the k-cluster. Further, we construct several data subsets through sampling with replacement to feed on the light gradient boosting machine (LightGBM) method. Finally, the voting method is applied to predict potential miRNA-disease relationships. As a result, ANMDA can achieve an area under the receiver operating characteristic curve (AUROC) of 0.9373 ± 0.0005 in five-fold cross-validation, which is superior to several published methods. In addition, we analyze the predicted miRNA-disease associations with high probability and compare them with the data in HMDD v3.0 in the case study. The results show ANMDA is a novel and practical algorithm that can be used to infer potential miRNA-disease associations.

Conclusion
The results indicate the noise hiding in the data has an obvious impact on predicting potential miRNA-disease associations. We believe ANMDA can achieve better results from this task with more methods used in dealing with the data noise.
Pheniqs 2.0: accurate, high-performance Bayesian decoding and confidence estimation for combinatorial barcode indexing
Authors: Galanti Lior , Shasha Dennis , Gunsalus Kristin C. 
Published: July 2021

Abstract
Background
Systems biology increasingly relies on deep sequencing with combinatorial index tags to associate biological sequences with their sample, cell, or molecule of origin. Accurate data interpretation depends on the ability to classify sequences based on correct decoding of these combinatorial barcodes. The probability of correct decoding is influenced by both sequence quality and the number and arrangement of barcodes. The rising complexity of experimental designs calls for a probability model that accounts for both sequencing errors and random noise, generalizes to multiple combinatorial tags, and can handle any barcoding scheme. The needs for reproducibility and community benchmark standards demand a peer-reviewed tool that preserves decoding quality scores and provides tunable control over classification confidence that balances precision and recall. Moreover, continuous improvements in sequencing throughput require a fast, parallelized and scalable implementation.

Results and discussion
We developed a flexible, robustly engineered software that performs probabilistic decoding and supports arbitrarily complex barcoding designs. Pheniqs computes the full posterior decoding error probability of observed barcodes by consulting basecalling quality scores and prior distributions, and reports sequences and confidence scores in Sequence Alignment/Map (SAM) fields. The product of posteriors for multiple independent barcodes provides an overall confidence score for each read. Pheniqs achieves greater accuracy than minimum edit distance or simple maximum likelihood estimation, and it scales linearly with core count to enable the classification of > 11 billion reads in 1 h 15 m using < 50 megabytes of memory. Pheniqs has been in production use for seven years in our genomics core facility.

Conclusion
We introduce a computationally efficient software that implements both probabilistic and minimum distance decoders and show that decoding barcodes using posterior probabilities is more accurate than available methods. Pheniqs allows fine-tuning of decoding sensitivity using intuitive confidence thresholds and is extensible with alternative decoders and new error models. Any arbitrary arrangement of barcodes is easily configured, enabling computation of combinatorial confidence scores for any barcoding strategy. An optimized multithreaded implementation assures that Pheniqs is faster and scales better with complex barcode sets than existing tools. Support for POSIX streams and multiple sequencing formats enables easy integration with automated analysis pipelines.