bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protecting vulnerable people during pandemics through home delivery of essential supplies: a distribution logistics model
Authors: Breitbarth Eric , Groβ Wendelin , Zienau Alexander 
Published: February 2021

PurposeThis paper studies a concept for protecting vulnerable population groups during pandemics using direct home deliveries of essential supplies, from a distribution logistics perspective. The purpose of this paper is to evaluate feasible and resource-efficient home delivery strategies, including collaboration between retailers and logistics service providers based on a practical application.Design/methodology/approachA food home delivery concept in urban areas during pandemics is mathematically modeled. All seniors living in a district of Berlin, Germany, represent the vulnerable population supplied by a grocery distribution center. A capacitated vehicle routing problem (CVRP) is developed in combination with a k-means clustering algorithm. To manage this large-scale problem efficiently, mixed-integer programming (MIP) is used. The impact of collaboration and additional delivery scenarios is examined with a sensitivity analysis.FindingsRoughly 45 medically vulnerable persons can be served by one delivery vehicle in the baseline scenario. Operational measures allow a drastic decrease in required resources by reducing service quality. In this way, home delivery for the vulnerable population of Berlin can be achieved. This requires collaboration between grocery and parcel services and public authorities as well as overcoming accompanying challenges.Originality/valueDeveloping a home delivery concept for providing essential goods to urban vulnerable groups during pandemics creates a special value. Setting a large-scale CVRP with variable fleet size in combination with a clustering algorithm contributes to the originality.
Accountability for climate change: a research synthesis through the lenses of the integrated thinking approach
Authors: Brunelli Sandro , Falivena Camilla , Carlino Chiara , Venuti Francesco 
Published: February 2021

PurposeThe increasing responsibility of organisations towards society and the environment has inverted the relationship between accounting and accountability, leading to accountability-based accounting systems. This study aims to explore the debate on accountability for climate change within the integrating thinking (IT) perspective. Ascertaining the most significant trends in the debate around purposes and performance that characterise climate mitigation engagement and their connections, the study would explore if and to what extent organisations are tackling climate actions.Design/methodology/approachA narrative review of the extensive academic literature developed from the Kyoto Protocol to date was performed. After selecting a representative sample, papers were analysed with the support of a new analytical framework that involves three dimensions – answerability, enforcement and outcome – and governance schemes that emerge from the involvement of the private and public sector and civil society. With the support of NVivo software, themes arisen were analysed and coded. Key items were labelled, creating specific nodes and synthesised into the proposed framework.FindingsA “silo approach” largely characterises the debate on accountability for climate change. The most significant reasons behind the shortcomings of extant climate actions may be retrieved firstly in the weakness of the motivations that guide organisations to operate in a climate-friendly way.Social implicationsThis study underlines the need for a 360° integrated approach for strategically tackling climate actions.Originality/valueThis study would represent a further step towards an integrated approach for studying organisations behaviours in the “climate war”, embracing the connectivity between purposes and outcomes, capitals and the relationships amongst the various stakeholders.
Emergence of circular economy research: a systematic literature review
Authors: Lahane Swapnil , Prajapati Himanshu , Kant Ravi 
Published: February 2021

PurposeThis paper aims to examine the current status and trends in circular economy (CE) research. The state of CE research is assessed by critically examining the field by considering diverse dimensions.Design/methodology/approachThe systematic literature review (SLR) of CE research articles is analyzed using the content analysis methodology. The articles are selected from the Scopus database containing the keyword “Circular economy” in its title, abstract and keywords. In total, 587 research articles published on CE in various reputed peer-reviewed journals over 15 years (2005–2020) are selected for review.FindingsThe research in the domain of CE is in the beginning phase. It has numerous quantitative modeling opportunities, value creation and propositions aspects and application in real-life case problems. One of the significant findings is that the CE research field is more inclined toward the implication of the empirical qualitative research. The identified research gaps and future opportunities could provide further direction to broaden CE research.Research limitations/implicationsThe review focuses on publications published in peer-reviewed journals in the English language only. It restricts the recognition of relevant articles published in conference proceedings and languages other than English.Originality/valueThis research study will provide a deeper understanding of CE research's existing status and highlights the research trends, gap and its applicability in real-life case problems and setting up future research directions in the CE field.
Exchange rate volatility and Turkish–German commodity trade: an asymmetry analysis
Authors: Bahmani-Oskooee Mohsen , Karamelikli Huseyin 
Published: February 2021

PurposeThe purpose of this paper is to show that in some industries the linear model may not reveal any significance link between exchange rate volatility and trade flows but once nonlinear adjustment of exchange rate volatility is introduced, the nonlinear model reveals significant link.Design/methodology/approachThis paper uses the linear ARDL approach of Pesaranet al.(2001) and the nonlinear ARDL approach of Shinet al.(2014) to assess asymmetric effects of exchange rate volatility on trade flows between Germany and Turkey.FindingsThis paper consider the experiences of 75 2-digit industries that trade between Turkey and Germany. When the study assumed the effects of volatility to be symmetric, the study found short-run effects in 31 (30) Turkish (German) exporting industries that lasted into the long run in only 10 (13) Turkish (German) exporting industries. However, when the study assumed asymmetric effects and relied upon a nonlinear model, the study found short-run asymmetric effects of volatility on exports of 55 (56) Turkish (German) industries. Short-run asymmetric effects lasted into long-run asymmetric effects in 10 (25) Turkish (German) exporting industries. All in all, we found that almost 25% of trade is hurt by exchange rate volatility.Originality/valueThis is the first paper that assesses the possibility of asymmetric effects of exchange rate volatility on German–Turkish commodity trade.
The experiences of older carers of people with learning disabilities: “I just carry on with it”
Authors: Forrester-Jones Rachel 
Published: February 2021

PurposeBecause people with learning disabilities (LD) are living longer, their family carers are likely to continue their caring role for longer. This study aims to explore the experiences of older carers of people with LD.Design/methodology/approachIn total, 16 interviews with older carers were carried out and analysed qualitatively.FindingsThree main themes emerged from the data: “transition to retirement is a misnomer”; “impact of caring role”; and “fears for the future”.Originality/valuePrevious studies have not focussed on the specific experiences of “older” carers and their situation risks going unnoticed. Their experiences should be acknowledged by services and society and meaningful support provided.
Fatal methemoglobinemia in three suicidal sodium nitrite poisonings
Authors: Dean Dorothy E. , Looman Karen B. , Topmiller Robert G. 
Published: February 2021

AbstractNitrites are chemicals that are abundant in the environment, widely used as preservatives for meat, and in pharmaceuticals. Volatile products containing nitrites have been used recreationally for the euphoric effect associated with mild hypoxia. Dietary exposure to small amounts is considered harmless. Deaths by ingestion of nitrite salts are not common, but accidental exposure and as suicidal and homicidal agents have been noted. Death is a consequence of oxidation of hemoglobin ferrous (Fe+2) iron (Hb) to the ferric (Fe+3) form (methemoglobin, MetHb), causing a reduction in the oxygen‐carrying capacity of the blood. We report three cases of ingestion of sodium nitrite in two college students (one mildly decomposed) and one adult in early middle age. All of the decedents in these cases developed fatal methemoglobinemia. Sodium nitrite in chemical form was found near the bodies. MetHb was detected in the postmortem blood of each decedent. The MetHb concentrations in the two decedents with a short postmortem interval were less than MetHb concentrations reported in the current literature. The MetHb concentrations reported in the mildly decomposed person were greater than for the other two, but still less than the concentration previously considered lethal. The data from these cases indicate that levels of MetHb can vary widely in fatal cases, and should not be used as the sole criterion for determination of a death caused by sodium nitrite. Following a discussion of the cases, there is a review of the pathophysiology of MetHb production and a current literature review.
Effects of oxidative modification of peroxyl radicals on the structure and foamability of chickpea protein isolates
Authors: Zhu Zengfang , Mao Xiaoying , Wu Qingzhi , Zhang Jian , Deng Xiaorong 
Published: February 2021

AbstractA chickpea protein isolate (CPI) was oxidized using peroxyl radicals derived from 2,2'‐azobis (2‐amidopropane) dihydrochloride (AAPH), and the structural and foaming properties of the oxidized CPI were evaluated. The oxidation degree of protein was determined by measuring carbonyl content, dimer tyrosine content, free thiol content, and total thiol content. The structural changes of oxidized protein were evaluated by surface hydrophobicity, endogenous fluorescence intensity, Fourier transform infrared spectroscopy, SDS‐PAGE, and amino acid content changes. Compared with the control group (0 mmol/L AAPH), moderate oxidation (0.04 mmol/L AAPH) led to the formation of a soluble protein with flexibility, which could improve the foaming properties of the protein (foaming capacity and stability increased by 25.50% and 6.38%, respectively). Over‐oxidized (25 mmol/L AAPH) protein exhibited improved foaming capability, but its foam stability was reduced owing to the formation of insoluble aggregates. The results indicate that oxidation can change protein conformation, and the protein structure can affect the foamability of the CPI.Practical ApplicationCPI is a protein supplement food. Protein oxidation can occur during processing and storage, thereby affecting protein function. In this study, we evaluated how peroxy free radicals affect the structure, solubility and foaming properties of CPI, and clarified the mechanism between them. It has been found that peroxy free radicals can accelerate the oxidation of proteins and have a significant effect on foaming. Therefore, the degree of oxidation should be controlled to improve the quality of CPI.
The addition of alpha amylase improves the quality of Chinese dried noodles
Authors: Wang Jin‐Rong , Guo Xiao‐Na , Li Yonghui , Zhu Ke‐Xue 
Published: February 2021

AbstractThe effect of α‐amylase on the quality attributes of Chinese dried noodles (CDN) was investigated. Adding α‐amylase markedly decreased the cooking time and cooking loss of CDN at the level of 12.5 (mg/100 g flour). The elasticity of CDN was increased significantly (P < 0.05) after adding α‐amylase. The firmness of noodles with 12.5 mg α‐amylase per 100 g flour showed no obvious change compared to the control, whereas it decreased significantly (P < 0.05) when the amount of α‐amylase increased to 25 (mg/100 g flour). In addition, the chewiness of CDN with 12.5 mg α‐amylase per 100 g flour increased, while it showed a significant (P < 0.05) decreasing trend with further increased α‐amylase levels. Starch structural and thermal properties were also changed by α‐amylase, which showed increased relative crystallinity, swelling power, but decreased pasting property. The changed starch property restrained the cross‐linking of gluten. The decrease in optimal cooking time and increase in elasticity of CDN were due to the increased swelling power and decreased peak time of the starch. In addition, the decreased setback of starch and protein cross‐linking degree were responsible for the decreased firmness and chewiness of CDN with α‐amylase ranging from 25 to 50 mg/100 g flour. Overall, α‐amylase could be used as a functional additive to improve the quality of CDN when the amount was at 12.5 mg/100 g flour.
Can computed tomography differentiate adenocarcinoma in situ from minimally invasive adenocarcinoma?
Authors: Yoshida Mitsuteru , Yuasa Masao , Ogawa Hirohisa , Miyamoto Naoki , Kawakami Yukikiyo , Kondo Kazuya , Tangoku Akira 
Published: February 2021

AbstractBackgroundGiven the subtle pathological signs of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), effective differentiation between the two entities is crucial. However, it is difficult to predict these conditions using preoperative computed tomography (CT) imaging. In this study, we investigated whether histological diagnosis of AIS and MIA using quantitative three‐dimensional CT imaging analysis could be predicted.MethodsWe retrospectively analyzed the images and histopathological findings of patients with lung cancer who were diagnosed with AIS or MIA between January 2017 and June 2018. We used Synapse Vincent (v. 4.3) (Fujifilm) software to analyze the CT attenuation values and performed a histogram analysis.ResultsThere were 22 patients with AIS and 22 with MIA. The ground‐glass nodule (GGN) rate was significantly higher in patients with AIS (p < 0.001), whereas the solid volume (p < 0.001) and solid rate (p = 0.001) were significantly higher in those with MIA. The mean (p = 0.002) and maximum (p = 0.025) CT values were significantly higher in patients with MIA. The 25th, 50th, 75th, and 97.5th percentiles (all p < 0.05) for the CT values were significantly higher in patients with MIA.ConclusionsWe demonstrated that quantitative analysis of 3D‐CT imaging data using software can help distinguish AIS from MIA. These analyses are useful for guiding decision‐making in the surgical management of early lung cancer, as well as subsequent follow‐up.
Predictors for assessing the flowering duration and dynamics of the complex umbellate of fennel in seed production
Authors: Lefort Céline , Raveneau Marie‐Paule , Cannavacciuolo Mario , Guerry Benoît , Fustec Joëlle 
Published: February 2021

AbstractFlowering is a critical stage of fennel seed production, which strongly depends on climate factors. In crops such as fennel, the complexity of the umbellate structure and the lack of knowledge about its flowering dynamics make the prediction of the duration of this phenological stage uneasy. In the context of climate change, a reliable predictive tool for the duration of fennel flowering is needed. Our aim was to increase knowledge on fennel flowering dynamics and to propose a model to be used by seed producers. In 2018 and 2019, we studied the development of secondary and tertiary umbels during flowering stage which was determined from the Bundesanstalt Bundessortenamt und Chemische Industrie scale, in plants of four genotypes grown in tunnels. Multiple linear regression (MLR) models were used to select the more accurate equations which consisted of one or more variables as predictors of flowering duration and its dynamics across secondary and tertiary umbels. In all model subsets, the criterion‐based procedure was used, followed by a criterion‐based hybrid procedure to take advantage of the Mallows' Cp, adjusted R2 and Bayesian information criterion, for equations and predictor selection. Two variables related to temperature, namely the temperature summation expressed in degree days and the number of days with temperature lower than 15°C, were identified as relevant parameters for predicting flowering duration expressed in days, in secondary as well as tertiary umbels. In addition, the equations and accurate predictors identified for modelling differences in time between flowering starts and ends of secondary and tertiary umbels also highlighted the importance of the number of days when the temperature amplitude is higher than 20°C, the number of days when the mean temperature is higher than 27°C, and the number of days when the relative humidity is higher than 80%.
Complete laparoscopic choledochal cyst excision and hepaticojejunostomy with laparoscopic Roux‐Y reconstruction using a 5‐mm stapler: A case of a 2‐month‐old infant
Authors: Murakami Masakazu , Kaji Tatsuru , Nagano Ayaka , Matsui Mayu , Onishi Shun , Yamada Koji , Ieiri Satoshi 
Published: February 2021

AbstractLaparoscopic choledochal cyst excision and hepaticojejunostomy for choledochal in children is performed only at particular institutions because of the technical difficulty. Although choledochal cyst excision and hepaticojejunostomy are feasible, the small working space of infants makes intraabdominal Roux‐Y reconstruction technically challenging. A 2‐month‐old girl diagnosed with a choledochal cyst underwent complete laparoscopic choledochal cyst excision and hepaticojejunostomy, including intraabdominal Roux‐Y reconstruction with a 5‐mm stapler. After cyst excision, Roux‐Y reconstruction was performed in the intraabdominal cavity. Jejunojejunostomy was performed in a side‐to‐side fashion using a 5‐mm stapler, and the entry hole was closed laparoscopically by hand‐sewing, along with the mesentery defect. All procedures were performed by laparoscopic surgery. The postoperative course was uneventful, and the patient showed a quick recovery. Using small‐diameter instruments, completely laparoscopic procedures for choledochal cyst are feasible.
Mental health at the intersections of marginalization: A conceptual model to explore the mental health concerns of women sanitation workers in India
Authors: Monteiro Tanya S. , Nalini R. 
Published: February 2021

AbstractIn India, sanitation work is predominantly undertaken by persons from oppressed castes whose customary roles relegate them to stigmatized occupations. Women sanitation workers, comprising nearly half of the urban workforce, grapple with multiply marginalized identities and social positions. Marginalized at the intersections of caste, gender, and occupation, they contend with violence and socio‐economic discrimination. The literature on the occupational and psychosocial risks of sanitation workers indicates that the mental health concerns of women sanitation workers remain largely unaddressed in research and public policy. This paper draws on an analytical review of research on women sanitation workers’ occupational and psychosocial risks with the objective of conceptualizing the relationship between marginalization and mental health. Utilizing intersectionality and social systems theories to present women sanitation workers as a critical case, their experiences of marginalization at the intersections of caste, gender, and occupation are analyzed. Consequently, a conceptual model of mental health outcomes at the intersections of multiply marginalized identities and social positions is developed to analyze the implications of marginalization for mental health. Guidelines for action to inform public policy and social work practice are suggested, emphasizing the need for intersectional interventions and a social justice framework in mental health care for marginalized groups.
A novel peptide isolated from garlic shows anticancer effect against leukemic cell lines via interaction with Bcl‐2 family proteins
Authors: Rasaratnam Karunaithas , Nantasenamat Chanin , Phaonakrop Narumon , Roytrakul Sittiruk , Tanyong Dalina 
Published: February 2021

AbstractLeukemia is a group of cancer caused by the abnormal proliferation and differentiation of hematopoietic stem cells. Efforts geared toward effective therapeutic strategies with minimal side effects are underway. Peptides derived from natural resources have recently gained special attention as alternative chemotherapeutic agents due to their minimal adverse effects. In the present study, the aim was to isolate peptides from garlic (Allium sativum) and investigate their anticancer activity against leukemic cell lines. The protein extract of A. sativum was pepsin‐digested to obtain protein hydrolysate followed by sequential purification methods. A novel anticancer peptide, VKLRSLLCS (VS‐9), was identified and characterized by mass spectrometric analysis. The peptide was demonstrated to significantly inhibit the cell proliferation of MOLT‐4 and K562 leukemic cell lines while exhibiting minimal inhibition against normal PBMC. Particularly, VS‐9 could induce apoptosis and upregulate mRNA levels of caspase 3, caspase 8, caspase 9, and Bax while downregulating Bcl‐2, Bcl‐xL, and Bcl‐w. Molecular docking of VS‐9 with the anti‐apoptotic Bcl‐2 protein family suggested that VS‐9 could bind the binding groove of the BH3 domain on target proteins. Protein–peptide interaction analysis by affinity chromatography and LC‐MS/MS further showed that VS‐9 could bind Bcl‐2 proteins. Results suggest VS‐9 as a potential garlic‐derived novel anticancer peptide possessing apoptosis‐inducing properties against leukemic cell lines via anti‐apoptotic Bcl‐2 protein family.
First insights into the genetics of 21‐hydroxylase deficiency in the Roma population
Authors: Kocova Mirjana , Anastasovska Violeta , Petlichkovski Aleksandar , Falhammar Henrik 
Published: February 2021

AbstractBackground21‐hydroxylase deficiency (21OHD) is an autosomal recessive disorder with an incidence of 1:10,000‐1:20,000 and is the result of various mutations in the CYP21A2 gene. 21OHD has been described in many different populations, but it has not been studied in Roma individuals so far. The aim of the study was to analyse the genotype in Roma patients with 21OHD and the prevalence of the disease in the Roma population of North Macedonia.MethodsMolecular analysis of the nine most frequent CYP21A2 mutations in all known Roma patients with CAH in North Macedonia, relatives and healthy individuals of Roma ancestry, using the PCR/ACRS method.ResultsTen Roma patients with 21OHD were identified, of which nine had the salt‐wasting and one had the simple virilizing form. Calculated incidence of 21OHD in the North Macedonian Roma population was 1:3375. Interestingly, 9/10 patients (90%) were homozygous for the In2G splicing mutation (293‐13A/C > G). Standard therapy with hydrocortisone and fludrocortisone had been introduced according to the guidelines. In 16 healthy relatives investigated for CYP21A2 mutations, heterozygosity for the In2G mutation was detected in 13/32 (40.6%) alleles. In 100 healthy Roma individuals, none related to the analysed families, no CYP21A2 mutations were detected.ConclusionThe Roma population in North Macedonia had a very high incidence of classic 21OHD. Almost all patients had the severe salt‐wasting form and the In2G/In2G genotype.