bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Mutualism Effects generate synergistic selection and strengthen fitness alignment in the interaction between legumes, rhizobia and mycorrhizal fungi
Authors: Afkhami Michelle E. , Friesen Maren L. , Stinchcombe John R. 
Published: June 2021

AbstractNearly all organisms participate in multiple mutualisms, and complementarity within these complex interactions can result in synergistic fitness effects. However, it remains largely untested how multiple mutualisms impact eco‐evolutionary dynamics in interacting species. We tested how multiple microbial mutualists—N‐fixing bacteria and mycorrrhizal fungi—affected selection and heritability of traits in their shared host plant (Medicago truncatula), as well as fitness alignment between partners. Our results demonstrate for the first time that multiple mutualisms synergistically affect the selection and heritability of host traits and enhance fitness alignment between mutualists. Specifically, we found interaction with multiple microbial symbionts doubled the strength of natural selection on a plant architectural trait, resulted in 2‐ to 3‐fold higher heritability of plant reproductive success, and more than doubled fitness alignment between N‐fixing bacteria and plants. These findings show synergism generated by multiple mutualisms extends to key components of microevolutionary change, emphasising the importance of multiple mutualism effects on evolutionary trajectories.
COVID‐19 lockdown consequences on body mass index and perceived fragility related to physical activity: A worldwide cohort study
Authors: Urzeala Constanta , Duclos Martine , Chris Ugbolue Ukadike , Bota Aura , Berthon Mickael , Kulik Keri , Thivel David , Bagheri Reza , Gu Yaodong , Baker Julien S. , Andant Nicolas , Pereira Bruno , Rouffiac Karine ,   The Covistress Network, Clinchamps Maëlys , Dutheil Frédéric 
Published: June 2021

AbstractBackgroundThis paper is a follow‐up study continuing the COVISTRESS network previous research regarding health‐related determinants.ObjectiveThe aim was to identify the main consequences of COVID‐19 lockdown on Body Mass Index and Perceived Fragility, related to Physical Activity (PA), for different categories of populations, worldwide.DesignThe study design included an online survey, during the first wave of COVID‐19 lockdown, across different world regions.Setting and participantsThe research was carried out on 10 121 participants from 67 countries. The recruitment of participants was achieved using snowball sampling techniques via social networks, with no exclusion criteria other than social media access.Main outcome measuresBody Mass Index, Physical Activity, Perceived Fragility and risk of getting infected items were analysed. SPSS software, v20, was used. Significance was set at P < .05.ResultsBody Mass Index significantly increased during lockdown. For youth and young adults (18‐35 years), PA decreased by 31.25%, for adults (36‐65 years) by 26.05% and for the elderly (over 65 years) by 30.27%. There was a high level of Perceived Fragility and risk of getting infected for female participants and the elderly. Correlations between BMI, Perceived Fragility and PA were identified.Discussion and ConclusionsThe research results extend and confirm evidence that the elderly are more likely to be at risk, by experiencing weight gain, physical inactivity and enhanced Perceived Fragility. As a consequence, populations need to counteract the constraints imposed by the lockdown by being physically active.
2. ON THE DOMESTICATION OF CRITICAL LEGAL HISTORY
Authors: DESAUTELS‐STEIN JUSTIN , MOYN SAMUEL 
Published: June 2021

ABSTRACTAmong many of today's legal historians, there is a relatively new and generally unreflective understanding of the relationship between history and method. The landscape is everywhere marked by a tendency to eschew big thinking, grand theory, and programmatic approaches to historical explanation and social transformation. In the place of the grand theory approach to law and history, there is a preference for the minimalist, the pragmatic, the particularistic, and the quotidian. What this normal science of today's legal historiography makes obvious is a kind of attachment to particular kinds of problems with particular sorts of built‐in solutions. The result for today is intellectual stagnation, a routinized and thoroughly domesticated mode of revealing contingency. Oddly, the fascination with contingency, and its deadening affair with a minimalist pragmatism, is itself a result of the triumph of what continues to be called “critical legal history.” Ostensibly due to an interface between critical legal studies and the historical discipline, the rise and triumph of critical legal history hides a secret: the whole idea of a reigning critical appreciation for contingency seems to be a misnomer. Sure, some may say that “things might have been otherwise.” But what this intellectual settlement demands is obedience to its qualification: “things might have been otherwise, but they weren't, and so let's get on with doing what works.” Although so‐called critical legal history seduces adherents with promises of edgy progressivism, the actual malaise of our minimalism seems in fact to suggest just the opposite. It is a quiescent and even quietistic method in practice, counseling in its conservatism against higher‐order proposals that might ever make good on the discovery that nothing is natural. In the end, either we must accept that critical legal history in the United States is a lot less politically explosive than we once thought—given its deradicalization and domestication today—or that people have been mistaken about what critical legal history was, is, and ought to be.
Organomorphic carbon–carbon composite for hot pressing molds
Authors: Bogachev Evgeny , Elakov Alexander 
Published: June 2021

AbstractOrganomorphic composites are obtained by pyrolysis of heat‐treated molded polymer fibers followed by compacting the resulting Ipresskon® preform using carbon or silicon carbide. The structure of these materials features the most uniform volume distribution of a fiber and a matrix. The carbon–carbon (C/C) composite bushings made in this way show a very high compressive strength (up to 390 MPa) and a radial tensile strength (150 MPa). These characteristics ensure high performance of hot pressing molds for ceramics conventionally made of isostatic graphite characterized by much lesser tensile strength. This paper describes the microstructure and properties of C/C‐Ipresskon® composite that was used instead of graphite as a hot pressing mold die. The material structure was found to show a slight transformation after 22 cycles of high‐temperature thermal/mechanical loading at a temperature up to 2000°C and 30–35 MPa.
Extended loci histocompatibility matching in HSCT—Going beyond classical HLA
Authors: Neuchel Christine , Fürst Daniel , Tsamadou Chrysanthi , Schrezenmeier Hubert , Mytilineos Joannis 
Published: June 2021

AbstractUnrelated haematopoietic stem cell transplantation (HSCT) has evolved from an experimental protocol to a potentially curative first‐line treatment in a variety of haematologic malignancies. The continuous refinement of treatment protocols and supportive care paired with ongoing achievements in the technological field of histocompatibility testing enabled this transformation. Without a doubt, HLA matching is still the foremost criterion for donor selection in unrelated HSCT. However, HSCT‐related treatment complications still occur frequently, often resulting in patients suffering severely or even dying as a consequence of such complications. Current literature indicates that other immune system modulating factors may play a role in the setting of HSCT. In this review, we discuss the current clinical evidence of a possible influence of nonclassical HLA antigens HLA‐E, HLA‐F, and HLA‐G as well as the HLA‐like molecules MICA and MICB, in HSCT.
Multi‐scale biodiversity analyses identify the importance of continental watersheds in shaping lake zooplankton biogeography
Authors: Paquette Cindy , Gregory‐Eaves Irene , Beisner Beatrix E. 
Published: June 2021

AbstractAimWe examined variation in crustacean zooplankton composition and diversity across Canada, the most lake‐rich country in the world. In addition to α‐diversity patterns, we explore mechanisms behind β‐diversity spatial variation, using taxonomic and functional metrics. Our goal was to explore geographical gradients and related mechanisms shaping zooplankton distribution across different spatial scales.LocationCanada.TaxonCrustacean zooplankton.MethodsPelagic zooplankton was sampled in and characterized for 624 lakes across Canada, spanning 12 ecozones (defined by climatic, vegetation and geological differences) or 6 continental drainage basins as part of the NSERC Canadian Lake Pulse Network project. We compared taxon and trait distributions, as well as spatial (longitudinal and latitudinal) patterns of community composition and diversity. We computed taxonomic and functional spatial β‐diversity indices, decomposing these into taxon replacement and richness differences. Finally, species (or traits) and lake uniqueness (contributions) to β‐diversity (SCBD and LCBD) were estimated by ecozone and continental basin.ResultsIn all, 90 crustacean zooplankton species were identified across the country. Differences in zooplankton taxonomic and functional composition were more distinct when considered by continental basin than by ecozone. α‐diversity varied greatly across space, with greatest diversity in eastern Canada. β‐diversity was greatest when based on taxonomy and was driven by richness differences across all spatial and biodiversity dimensions.Main conclusionsStructuring factors influencing zooplankton taxon and trait assemblages vary across spatial scales, being more important at the broadest scale considering continental hydrodynamics. Our results point to the combined effects of physical barriers to longitudinal dispersal and climate change in shaping zooplankton taxonomic and functional biogeography across Canadian lakes.
Case of type 2 diabetes mellitus with edema resulting in subcutaneous insulin resistance syndrome
Authors: Hu Ying , Zhu Qiongwen , Yang Xiuli , Yan Jieping , Shi Jiana 
Published: June 2021

AbstractSubcutaneous insulin resistance syndrome caused by obesity, induration at the injection site, skin temperature and other factors is common clinically, whereas resistance events caused by edema are relatively rare. This article introduced a case of a woman with type 2 diabetes mellitus with heart failure edema. Her blood glucose control was significantly associated with the level of edema. Excluding other factors, it can be concluded that edema might lead to subcutaneous insulin resistance syndrome, even if the edema at the injection site is not obvious.
Can emergency nurses safely and effectively insert fascia iliaca blocks in patients with a fractured neck of femur? A prospective cohort study in an Australian emergency department
Authors: Gawthorne Julie , Stevens Jennifer , Faux Steven G. , Leung Julie , McInnes Elizabeth , Fasugba Oyebola , Mcelduff Benjamin , Middleton Sandy 
Published: June 2021

Aims and objectivesTo compare the effectiveness and safety of ultrasound‐guided fascia iliaca block (FIB) insertion in patients with fractured neck of femur by trained emergency nurses with insertion by doctors.BackgroundThe FIB is an effective and safe form of analgesia for patients with hip fracture presenting to the emergency department (ED). While it has traditionally been inserted by medical doctors, no evidence exists comparing the effectiveness and safety of FIB insertion by nurses compared with doctors.DesignA prospective cohort study.MethodsThe study was conducted in an Australian metropolitan ED. Patients admitted to the ED with suspected or confirmed fractured neck of femur had a FIB inserted under ultrasound guidance by either a trained emergency nurse or doctor. A retrospective medical record audit was undertaken of consecutive ED patients presenting between January 2013–December 2017. Reporting of this study followed the Strengthening the Reporting of Observational Studies in Epidemiology guidelines for cohort studies.ResultsOf the 472 patients eligible for a FIB, 322 (68%) had one inserted. A majority were inserted by doctors (n = 207, 64.3%) with 22.4% (n = 72) by nurses and in 13.3% (n = 43) of patients the clinician was not documented. There were no differences between the nurse‐inserted and doctor‐inserted groups for mean pain scores 1 hr post‐FIB insertion; clinically significant reduction (≥30%) in pain score 1 hr post‐FIB insertion; pain score 4 hr post‐FIB insertion; delirium incidence; opioid use post‐FIB insertion; or time to FIB insertion. No adverse events were identified in either group.ConclusionInsertion of FIBs by trained emergency nurses is as effective and safe as insertion by doctors in patients with fractured neck of femur in the ED. Senior emergency nurses should routinely be inserting FIB as a form of analgesia for patients with hip fracture.Relevance to clinical practiceOur study showed trained emergency nurses can safely and effectively insert fascia iliaca blocks in patients with hip fractures. Pain was significantly reduced in a majority of patients with no reported complications. Emergency nurses should be trained to insert fascia iliaca blocks in patients with hip fractures.
Pressure ulcer risk assessment—registered nurses´ experiences of using PURPOSE T: A focus group study
Authors: Hultin Lisa , Gunningberg Lena , Coleman Susanne , Karlsson Ann‐Christin 
Published: June 2021

AbstractAimTo evaluate the clinical usability of PURPOSE T among registered nurses in Sweden.BackgroundPressure ulcers are an adverse event and a problem worldwide. Risk assessment is a cornerstone, and a first step in pressure ulcer prevention is to identify possible risk patients and/or pressure ulcers. There are many pressure ulcer risk assessment instruments; however, they are not updated and/or evidence‐based. PURPOSE T has been psychometrically evaluated in the UK and in Sweden with good inter‐rater and test–retest reliability, and convergent validity was reported as moderate.DesignA descriptive study design with a qualitative approach.MethodsA total of six focus group interviews with 29 registered nurses were conducted. They were recruited from May 2018 to November 2018 from a university hospital and two nursing homes in Sweden. Data analysis was performed as described by Krueger. The study adheres to the COREQ guidelines.ResultsFour categories were identified: “An efficient risk assessment instrument performed at the bedside,” “Deeper understanding and awareness of risk factors,” “Benefits compared to the Modified Norton Scale” and “Necessity of integration of PURPOSE T in the electronic health record and team collaboration.”ConclusionThe registered nurses acknowledged an overall positive perception of PURPOSE T´s clinical usability. Future research is needed to evaluate the feasibility of PURPOSE T.Relevance to Clinical PracticePURPOSE T has the potential to replace outdated pressure ulcers risk assessment instruments that are used today.
Effects of Achyranthesjaponica extract on the performance of finishing pigs fed diets containing palm kernel meal and rapeseed meal as a partial alternative to soybean meal
Authors: Sureshkumar Shanmugam , Kim Yong Min , Sampath Vetriselvi , Kim In Ho 
Published: June 2021

AbstractA total of 120 finishing pigs with an average initial body weight of 49.72 ± 0.08 kg (mean ± SD) were used in a 10 weeks trial. Pigs were randomly allotted into one of four dietary treatments (6 replicate pen/treatment, 5 pigs/pen). The nutritional dietary treatments were corn, soy bean meal, palm‐ kernel meal, and rapeseed meal based basal diets supplemented with 0, 0.05, 0.10, and 0.20% of Achyranthes japonica extract (AJE). Dietary inclusion of AJE supplementation had trend to increase the body weight and average daily gain of pigs at week 10 and the overall experimental period, respectively. The graded level of AJE supplement had increase the total track digestibility dry matter (p = 0.067) only at week 5 while nitrogen and energy digestibility (p < 0.05) was linearly increased at both weeks 5 and 10. During week 10, pigs fed with an increased level of AJE supplementation had linearly increase (p < 0.05) fecal Lactobacillus counts. In addition, AJE supplementation in the diet of finishing pigs had linearly decreased (p > 0.05) NH3 emission of gas and trend to decrease total mercaptans during week 10. Dietary inclusion of AJE supplement resulted in a linear increase in the blood protein concentration level. Moreover, drip loss was linearly reduced on day 5 and day 7 (p > 0.05) post slaughter in finishing pigs fed with gradually increased levels of AJE supplementation. During weeks 5 and 10, pigs fed with graded levels of AJE supplementation had linearly increase (p < 0.05) the backfat thickness and lean meat percentage. Therefore we conclude that dietary inclusion of AJE with palm kernel meal and rapeseed meal could be benificial to enhance the growth performance, nutrient digestibility, fecal microbial, blood prolife, meat quality and reduced fecal gas emission in finishing pigs.
The trace element composition of chondrule constituents: Implications for sample return methodologies and the chondrule silicate reservoir
Authors: Kunihiro Tak , Ota Tsutomu , Yamanaka Masahiro , Potiszil Christian , Nakamura Eizo 
Published: June 2021

AbstractSample return missions represent great opportunities to study terrestrially uncontaminated solar system materials. However, the size of returned samples will be limited, and thus, it is necessary to understand the most appropriate techniques to apply. Accordingly, the sensitivity of laser ablation inductively coupled plasma mass spectrometry (LA‐ICPMS) and secondary ion mass spectrometry (SIMS) was compared through the analyses of trace elements in reference materials and the Allende CV3 chondrite. While the SIMS method was found to be more sensitive than the laser method toward all elements of interest, the LA‐ICPMS appears to be more suitable in terms of precision for certain elements. Using both analytical techniques, we measured chemical composition of an Allende chondrule and its igneous rim. These data were used to understand the nature of the reservoir that interacted with the host chondrule during formation of its igneous rim. We find that the igneous rim is enriched in silica, alkalis, and rare earth elements compared to the host chondrule. We suggest that the igneous rim could be explained by melting of a mixture of the chondrule‐like and REE‐enriched CAI‐like precursors that accreted on the surface of the host chondrule followed by gas‐melt interaction with a silica‐ and alkali‐rich gas. Alternatively, these observations could be interpreted as a result of interaction between the chondrule and the melt resulting from partial melting of a pre‐existing planetesimal in the early stages of its differentiation.
ARGONAUTE 2 increases rice susceptibility to rice black‐streaked dwarf virus infection by epigenetically regulating HEXOKINASE 1 expression
Authors: Wang Zhaoyun , Chen Dongyue , Sun Feng , Guo Wei , Wang Wei , Li Xuejuan , Lan Ying , Du Linlin , Li Shuo , Fan Yongjian , Zhou Yijun , Zhao Hongwei , Zhou Tong 
Published: June 2021

AbstractARGONAUTE (AGO) proteins play crucial roles in plant defence against virus invasion. To date, the role of OsAGO2 in rice antiviral defence remains largely unknown. In this study, we determined that the expression of OsAGO2 in rice was induced upon rice black‐streaked dwarf virus (RBSDV) infection. Using transgenic rice plants overexpressing OsAGO2 and Osago2 mutants generated through transposon‐insertion or CRISPR/Cas9 technology, we found that overexpression of OsAGO2 enhanced rice susceptibility to RBSDV infection. Osago2 mutant lines exhibited strong resistance to RBSDV infection through the elicitation of an early defence response, including reprogramming defence gene expression and production of reactive oxygen species (ROS). Compared to Nipponbare control, the expression level of OsHXK1 (HEXOKINASE 1) increased significantly, and the methylation levels of its promoter decreased in the Osago2 mutant on RBSDV infection. The expression profile of OsHXK1 was the opposite to that of OsAGO2 during RBSDV infection. Overexpression of OsHXK1 in rice also induced ROS production and enhanced rice resistance to RBSDV infection. These results indicate that OsHXK1 controls ROS accumulation and is regulated by OsAGO2 through epigenetic regulation. It is noteworthy that the Osago2 mutant plants are also resistant to southern rice black‐streaked dwarf virus infection, another member of the genus Fijivirus. Based on the results presented in this paper, we conclude that OsAGO2 modulates rice susceptibility to fijivirus infection by suppressing OsHXK1 expression, leading to the onset of ROS‐mediated resistance. This discovery may benefit future rice breeding programmes for virus resistance.
The Measurement of the Inclination Angle of the Hamate and Analysis of the Inclination Angle for the Rotation Deformity of the Little Finger in the Fixation of the Carpometacarpal Joint
Authors: Qi Yimin , Liu Chengxin , Wu Lei , Yang Lei , Zhao Lei , Jiang Chunzhi , Yang Wengbo , Zeng Yiwen 
Published: June 2021

ObjectiveComplex base fractures of the fifth metacarpal bone and dislocation of the fifth carpometacarpal joint are more prone to internal rotation deformity of the little finger sequence after fixation with a transarticular plate. In the past, we have neglected that there is actually a certain angle of external rotation in the hamate surface of transarticular fixation. This study measured the inclination angle of the hamate surface relative to the fifth metacarpal surface for clinical reference.MethodsIn a prospective single‐center study, we investigated the tilt angle of 60 normal hamates. The study included thin‐layer computed tomography (CT) data from 60 patients from the orthopaedic clinic and inpatient unit from January 2017 to March 2020, including 34 men and 26 women who were 15~59 years old, average 35 years old. The CT data of 60 cases in Dicom format of the hand was input into Mimics and 3‐Matics software for three‐dimensional (3D) reconstruction and measuring the angle α between hamate surface and the fifth metacarpal surface. According to the possible placement of the transarticular plate on the fifth metacarpal surface, we measured the angle β between the hamate surface 1 and the fifth metacarpal surface and the angle γ between the hamate surface 2 and the fifth metacarpal surface.ResultsThe average angle between the hamate surface and the fifth metacarpal surface was 11.66°. The hamate surfaces 1 and 2 have an external rotation angle of 7.30° and 7.51° on average with respect to the fifth metacarpal surface, respectively. There is no statistically significant difference in the angles between the two groups (P > 0.05).ConclusionsThe horizontal angle of the dorsal side of the hamate is different from the back of the fifth metacarpal surface, and the hamate has a certain external rotation angle with respect to the fifth metacarpal surface. No matter how the transarticular plate is placed, the plate always has a certain external rotation angle relative to the fifth metacarpal surface. When the fixation is across the fifth carpometacarpal joint, if the plate does not twist and shape, it will inevitably cause internal rotation of the fifth metacarpal, resulting in internal rotation deformity of the little finger sequence.