bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudo bibliométrico da produção científica internacional sobre o uso de produtos naturais como terapia para o câncer de pâncreas
Authors: Guerra Bruno Mendes Moura Dias , Mascarenhas Caliza Calmon de Araújo , Rodrigues Ricardo Vieira Bezerra Luz , Carvalho Mateus Nunes , Nery Raissa Pinheiro , Rocha Iane Lopes da , Barros Mario Abel Lima , Sousa André Luca Araujo de , Pinto Antonione Santos Bezerra 
Published: August 2021

Introdução: Devido ao alto índice de invasão, malignidade e desenvolvimento assintomático, o câncer de pâncreas é altamente letal. Uma pequena quantidade de drogas está disponível para sua abordagem. Objetivo: Diante disso, o presente estudo objetiva mapear a produção científica internacional sobre o uso de produtos naturais como terapia para o câncer de pâncreas. Método: Foi realizada uma pesquisa bibliométrica em trabalhos acadêmicos no Web of Science publicados de 1998 a 2019 usando os termos de busca: "pancreatic cancer", "therapy" e "natural product". Foram identificados, após aplicados os filtros de refinamento, 123 registros de publicação em 82 periódicos distintos indexados à base de dados em questão, escritos por 755 autores que possuem vínculos à 237 instituições, localizadas em 37 países. Resultado: Avaliou-se a distribuição da quantidade de publicações por ano, os periódicos mais citados e mais relacionados entre si, os top periódicos com mais citações, a quantidade de artigos por país de origem das instituições de vínculo dos autores, os artigos mais citados e a co-ocorrência de palavras mais citadas e mais relacionados entre si. Conclusão: Embora publicações recentes tenham identificado mecanismos de ação envolvidos na interação de variados produtos naturais com o câncer de pâncreas, estamos longe de entender o espectro de efeitos que a terapêutica natural exerce sobre as células normais e cancerígenas. Novos estudos sobre o tema deverão ser realizados e a quantidade e qualidade das publicações acerca do tema deverão crescer ainda mais.
Can preterm birth affect the palate morphology? A systematic review
Authors: Oppitz Layza Rossatto , Gonçalves Flavio Magno , Schneider Neblyssa Agatha , Arantes Ana Carolina Mastriani , Miranda Bruna Marlene de , Guariza-Filho Odilon , Johann Aline Cristina Batista Rodrigues , Araujo Cristiano Miranda de , Camargo Elisa Souza 
Published: August 2021

The purpose of this review was to evaluate whether preterm birth affects palate morphology. Opened electronic search in PubMed (MEDLINE), Lilacs, Scopus and Web of Science was conducted and a partial search of the gray literature using Google Scholar, Open Gray and ProQuest. We included studies with infants born prematurely (born up to the 37th week of gestation and weighing less than 2.500 g) and not preterm infants; intubated and not intubated. Two independent reviewers performed study selection, data extraction, and bias risk assessment. Selection criteria included observational, retrospective and prospective, randomized or nonrandomized cohort studies and control studies. There was no restriction on publication time and article language. A total of 2344 articles were found after the duplicates were removed, of which 7 met the inclusion criteria and were submitted to a Bias Risk analysis using MASTARI. Scientific evidence was found for altered palate morphology among premature infants, and oral intubation was a contributing factor for such alterations. Based on this review, it is concluded that premature birth changes palate morphology, when prematurity is associated with the use of the orotracheal tube.
Deixis In Jakarta Post Article
Authors: Adi Mohammad Sofyan , Rahmat Muhamad Bagus Iqbal 
Published: August 2021

The design of this research was descriptive qualitative research that aimed at describing, interpreting and explaining deixis in the newspaper article. The main instrument in this study the researcher himself in doing his analysis supported by using the documentary technique. The data that had been collected were analyzed by the researcher himself. After analyzing the data, then the researcher drew the conclusion about the types and the function of deixis in the sentences of the newspaper articles. Based on the discussion findings, there were four types of deixis found in The Jakarta Post article, namely 19 person deixis, 29 spatial deixes , 59 time deixis, 55 discourse deixis. From the analysis, the most types of deixis found in Jakarta Post articles time deixis. Thus, it can be said that The Jakarta Post tends to use time deixis as the dominant type compound than another.
ANTASed – An Updated Sediment Model for Antarctica
Authors: Baranov A. , Morelli A. , Chuvaev A. 
Published: August 2021

We compile existing seismic, gravity, radar and magnetic data, together with the subglacial bedrock relief from the BEDMACHINE project, to build the most detailed sediment model for Antarctica. We interpolate these data according to a tectonic map of Antarctica using a statistical kriging method. Our results reveal significant sediment accumulation in Antarctica with several types of sedimentary basins: parts of the Beacon Supergroup and more recent rifting basins. The basement relief closely resembles major geological and tectonic structures. The thickness of sediments has significant variations around the continent, and depends on the degree of crustal extension. West Antarctica has wide sedimentary basins: the Ross basin (thickness 2–6 km), the Filchner-Ronne basin (2–12 km) with continuations into East Antarctica, the Bentley Subglacial Trench and the Byrd basin (2–4 km). The deepest Filchner-Ronne basin has a complex structure with multi-layered sediments. East Antarctica is characterized by vast sedimentary basins such as the Pensacola-Pole (1–2 km), Coats Land (1–3 km), Dronning Maud Land (1–2 km), Vostok (2–7 km), Aurora (1–3 km), Astrolabe (2–4 km), Adventure (2–4 km), and Wilkes (1–4 km) basins, along with narrow deep rifts filled by sediments: JutulStraumen (1–2 km), Lambert (2–5 km), Scott, Denman, Vanderford and Totten (2–4 km) rifts. The average thickness of sediments for the whole continent is about 0.77 km. The new model, ANTASed, represents a significant improvement over CRUST 1.0 for Antarctica, and reveals new sedimentary basins. Differences between ANTASed and CRUST 1.0 reach +12/−3 km.
MicroRNAs as Biomarkers for the Diagnosis of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis
Authors: Li Jiangbi , Xie Xiaoping , Liu Weibing , Gu Feng , Zhang Ke , Su Zilong , Wen Qiangqiang , Sui Zhenjiang , Zhou Pengcheng , Yu Tiecheng 
Published: August 2021

Background: Abnormal expression levels of microRNAs (miRNAs) were observed in ankylosing spondylitis (AS) in recent articles, suggesting that miRNAs may be used as biomarkers for AS diagnoses. In this paper, we conducted a meta-analysis to identify the overall diagnostic accuracy of miRNA biomarkers in AS patients.Methods: An extensive search was undertaken in PubMed, Embase, Cochrane databases, and Wan Fang database up to 30 December 2020 using the following key words: (“microRNAs” or “microRNA” or “miRNA” or “miR” or “RNA, Micro” or “Primary MicroRNA”) and (“Spondylitis Ankylosing” or “Spondyloarthritis Ankylopoietica” or “Ankylosing Spondylarthritis” or “Ankylosing Spondylarthritides” or “Spondylarthritides Ankylosing” or “Ankylosing Spondylitis”) and (“blood” or “serum” or “plasma”). Statistical evaluation of dysregulated miRNAs using the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the curve (AUC).Results: Twenty-nine articles reporting on the miRNAs of AS were included. A total of 42 miRNAs were observed to be up-regulated and 45 miRNAs were down-regulated in the AS cases compared with the controls. Besides, 29 studies from nine articles were included in our meta-analysis. The pooled sensitivity, specificity, PLR, NLR, DOR, and AUC were 0. 76 (95% CI, 0.70–0.81), 0.80 (95% CI, 0.74–0.85), 3.75 (95% CI, 2.82–5.01), 0.30 (95% CI, 0.24–0.39), 12.32 (95% CI, 7.65–19.83), 0.85 (95% CI, 0.81–0.88), respectively, suggesting a good diagnostic accuracy of miRNAs for AS.Conclusions: Circulating miRNAs are deregulated in AS patients. miRNAs may be used as a relatively non-invasive biomarkers for the detection of AS.
Nailfold Capillaroscopy Abnormalities Correlate With Disease Activity in Adult Dermatomyositis
Authors: Johnson Dylan , van Eeden Charmaine , Moazab Naima , Redmond Desiree , Phan Cecile , Keeling Stephanie , Gniadecki Robert , Cohen Tervaert Jan Willem , Osman Mohammed 
Published: August 2021

Objectives:The aim of this study was to determine the relationship between disease activity in adult patients with dermatomyositis (DM) and other biomarkers of disease activity such as C-reactive protein creatinine kinase and nailfold video capillaroscopy (NVC).Methods:We performed a prospective single center study of 15 adult patients with DM. Study participants underwent two assessments at least 9 months apart including clinical, laboratory and NVC evaluations. Patients received immunosuppressive medications for their dermatomyositis, and ongoing disease activity was measured by the Myositis Intention to Treat Index (MITAX). NVC evaluation included assessment of capillary density, capillary apical diameter (mm), and the number of microhemorrhages per digit.Results:Microvascular abnormalities were present in most DM patients. Of these, capillary density (4.71 vs. 6.84,p= 0.006) and mean apical diameter (56.09 vs. 27.79 μm,p= 0.003) significantly improved over the study period in concordance with improving disease control (MITAX 8.53 vs. 2.64,p= 0.002). Longitudinal analysis demonstrated that capillary density was independently associated with MITAX (β = −1.49 [CI −2.49, −0.33],p= 0.013), but not other parameters such as C-reactive protein and creatinine kinase.Conclusions:Nailfold capillary density is a dynamic marker of global disease activity in adult DM. NVC may be utilized as a non-invasive point-of-care tool to monitor disease activity and inform treatment decisions in patients with DM.
Development and Validation of Nomograms to Predict Operative Link for Gastritis Assessment Any-Stage and Stages III–IV in the Chinese High-Risk Gastric Cancer Population
Authors: Wang Song , Ye Fei , Sheng Yuan , Yu Wenyong , Liu Yingling , Liu Dehua , Zhang Kaiguang 
Published: August 2021

Purpose: It is very essential to diagnose gastric atrophy in the area with high prevalence of gastric cancer. Operative link for gastritis assessment (OLGA) was developed to detect the severity of gastric atrophy. The aim of this study was to develop and validate nomograms for predicting OLGA any-stage and stages III–IV in the Chinese high-risk gastric cancer population.Methods: We retrospectively analyzed 7,945 participants obtained by a multicenter cross-sectional study. We randomly selected 55% individuals (4,370 participants, training cohort) to analyze and generate the prediction models and validated the models on the remaining individuals (3,575 participants, validation cohort). A multivariate logistic regression model was used to select variables in the training cohort. The corresponding nomograms were developed to predict OLGA any-stage and stages III–IV, respectively. The area under the receiver operating characteristic curves and the GiViTI calibration belts were used to estimate the discrimination and calibration of the prediction models.Results: There were 1,226 (28.05%) participants in the training sample and 970 (27.13%) in the validation sample who were diagnosed with gastric atrophy. The nomogram predicting OLGA any-stage had an area under the curve (AUC) of 0.610 for the training sample and 0.615 for the validation sample, with favorable calibrations in the overall population. Similarly, the nomogram predicting OLGA stages III–IV had an AUC of 0.702 and 0.714 for the training and validation samples, respectively, with favorable calibrations in the overall population.Conclusions: The prediction model can early identify the occurrence of gastric atrophy and the severity stage of gastric atrophy to some extent.
Why Me? To Be an Ultra-Responder to Antiplatelet Therapy: A Case Report
Authors: Rosafio Francesca , Bigliardi Guido , Lelli Nicoletta , Vandelli Laura , Naldi Federica , Ciolli Ludovico , Meletti Stefano , Zini Andrea 
Published: August 2021

Background: Platelet function testing is a valid tool to investigate the clinical response to antiplatelet therapy in different clinical settings; in particular, it might supply helpful information in patients with cerebrovascular disease. Oral antiplatelet treatment, such as Aspirin (ASA) and Clopidogrel, is the gold standard in secondary stroke prevention of non-cardiogenic ischemic stroke; conversely, its application as a primary prevention therapy is not routinely recommended in patients with vascular risk factors. Multiple electrode platelet aggregometry (MEA) impedance aggregometer is a validated device to test platelet inhibition induced by ASA or Clopidogrel.Case Report: We report the case of a 78-year-old patient without relevant clinical history, taking ASA as primary prevention strategy, who was admitted for sudden onset of dysarthria and left facial hyposthenia during physical effort. Brain CT revealed two small subcortical bilateral spontaneous intracranial hemorrhages. Platelet aggregometry with MEA performed upon admission revealed a very strong platelet inhibition induced by ASA (result of the ASPI Test was 5 U, consistent with an ultra-responsiveness to ASA, and the cutoff value of correct responsiveness is &lt;40 U). MRI at longitudinal follow-up revealed the presence of two small cavernous angioma underlying hemorrhagic spots.Conclusion: The evaluation of platelet reactivity in stroke patients undergoing antiplatelet therapies, not commonly performed in clinical practice, could be useful to optimize prevention strategies; the verification of the biological effectiveness of ASA or Clopidogrel could be a valid tool in the definition of each patient's risk profile, particularly in patients with cerebrovascular disease known to be at increased risk for both hemorrhagic and thrombotic complications.
Certain Associations Between Iron Biomarkers and Total and γ' Fibrinogen and Plasma Clot Properties Are Mediated by Fibrinogen Genotypes
Authors: Rautenbach Petro H. , Nienaber-Rousseau Cornelie , de Lange-Loots Zelda , Pieters Marlien 
Published: August 2021

Introduction: Evidence for the relationship between body iron and cardiovascular disease (CVD) is inconsistent and mechanisms involved remain poorly understood. Therefore, we first investigated whether there are linear or non-linear relationships between iron status and total and γ' fibrinogen as well as plasma fibrin clot properties and, second, determined whether there are interactions with iron biomarkers and fibrinogen and FXIII single nucleotide polymorphisms (SNPs) in relation to fibrinogen concentration and functionality.Methods: In this cross-sectional analysis of 2,010 apparently healthy Black South Africans we quantified total and γ' fibrinogen, serum iron, ferritin and transferrin using standardized methods and calculated transferrin saturation (TS). Clot architecture and lysis were explored with a global analytical turbidity assay. The SNPs were determined through an Illumina BeadXpress® platform.Results: Total, but not %γ', fibrinogen negatively correlated with serum iron concentrations, although both decreased over iron tertiles. %γ' fibrinogen correlated negatively with transferrin and decreased over the transferrin tertiles. A weak negative association between total fibrinogen and TS was detected with fibrinogen decreasing over the TS tertiles and categories based on TS. Lag time correlated positively with transferrin and increased over transferrin tertiles, when adjusting for fibrinogen. Before adjusting for fibrinogen, lag time was shorter in those with adequate iron status based on TS than other iron subcategories. Clot lysis time (CLT) negatively correlated with ferritin and was longer in the first than in the third ferritin tertile. Among iron status categories based on ferritin, only CLT differed and was longer in those with adequate iron than with iron-overload. CLT negatively correlated with TS, albeit weakly, shortened over the TS tertiles and was shorter in those with adequate iron based on TS categories. Interactions were observed between FGB SNPs and some of the markers of iron status investigated, in relation to the clot properties with the most prominent associations detected in homozygous carriers of the variant alleles for whom increased iron status was more beneficial than for those harboring the wild-type alleles. Iron modulated the influence of the SNPs so that for the majority iron was beneficial in respect of clot properties, but even more so for a minority group harboring specific variant alleles.Conclusion: This is the first large-scale epidemiological study to relate fibrinogen concentration and functionality to markers of iron status and to take genetic factors into consideration. We have detected a relationship between iron biomarkers and fibrinogen as well as clot characteristics that are influenced by the genetic make-up of an individual.
Actions and the Self: I Give, Therefore I am?
Authors: Regner Tobias , Matthey Astrid 
Published: August 2021

Self-signaling models predict less selfish behavior in a probabilistic giving setting as individuals are expected to invest in a pro-social identity. However, there is also substantial evidence that people tend to exploit situational excuses for selfish choices (for instance, uncertainty) and behave more selfishly. We contrast these two motivations (identity management and self-deception) experimentally in order to test which one is more prevalent in a reciprocal giving setting. Trustees' back transfer choices are elicited for five different transfer levels of the trustor. Moreover, we ask trustees to provide their back transfer schedule for different scenarios that vary the implementation probability of the back transfer. This design allows us to identify subjects who reciprocate and analyze how these reciprocators respond when self-image relevant factors are varied. Our results indicate that self-deception is prevalent when subjects make the back transfer choice. Twice as many subjects seem to exploit situational excuses than subjects who appear to invest in a pro-social identity.JEL classifications: C72, C91, D80, D91
Public Opinion and Expectations: Development of Public Health Education in China After COVID-19 Pandemic
Authors: Shen Xin , Li Crystal Jingru , Dong Tianyi , Cao Hui , Feng Jing , Lei Zihui , Wang Zijian , Han Xiaotong , Lv Chuanzhu , Gan Yong 
Published: August 2021

Background: Policymakers must promote the development of public health education and human resources. As a feature of the political environment, public opinion is essential for policy-making, but virtually the attitudes of Chinese citizens toward human resources development in public health is unknown.Methods: This study conducted a crosssectional survey from February 4, 2021 to February 26, 2021 in China. We adopted a convenient sampling strategy to recruit participators. Participants filled out the questions, which assess the attitudes of the expanding public health professionals. A logistic regression analysis was given to identify the predictors associated with the attitudes of the subjects.Results: There were 2,361 residents who have finished our questionnaire. Chinese residents who lived in urban (OR = 1.293, 95% CI = 1.051–1.591), “themselves or relatives and friends have participated in relevant epidemic prevention work” (OR = 1.553, 95% CI = 1.160–2.079), “themselves or family members engaged in medical-related work” (OR = 1.468, 95% CI = 1.048–2.056), and those who “were aware of public health before the outbreak of COVID-19” (OR = 1.428, 95% CI = 1.125–1.812) were more likely to support the promotion of public health education and training.Conclusions: The present study found that 74.50% of Chinese citizens supported the promotion of public health education and training in China, in which economic status, personal perception, and comprehension are the crucial factors that influence public opinion. COVID-19 has aroused the attention of Chinese residents to public health education, with only 22.11% of residents being aware of public health before the outbreak of COVID-19. The COVID-19 pandemic has profound implications for human society. Literally, this impact will feed back into future public health policies based on public opinion. This innovative perspective will also help us better understand the potential social impact of COVID-19 on human resources and development for health in the modern world.
The Antimicrobial Properties of Nanotitania Extract and Its Role in Inhibiting the Growth of Klebsiella pneumonia and Haemophilus influenza
Authors: Harun Ahmad Mukifza , Noor Nor Farid Mohd , Zaid Awatief , Yusoff Mohamad Ezany , Shaari Ramizu , Affandi Nor Dalila Nor , Fadil Fatirah , Rahman Mohd Azizi Abdul , Alam Mohammad Khursheed 
Published: August 2021

Titanium dioxide (TiO2) is an antimicrobial agent which is considered of potential value in inhibiting the growth of multiple bacteria. Klebsiella pneumonia and Haemophilus influenza are two of the most common respiratory infection pathogens, and are the most. Klebsiella pneumonia causes fatal meningitis, while Haemophilus influenza causes mortality even in younger patients. Both are associated with bacteremia and mortality. The purpose of this study was to test a new antibacterial material, namely nanotitania extract combined with 0.03% silver that was developed at Universiti Malaysia Sabah (UMS) and tested against K. pneumonia and H. influenza. The nanoparticles were synthesized through a modified hydrothermal process, combined with molten salt and proven to have excellent crystallinity, with the band-gap energy falling in the visible light spectrum. The nanoparticle extract was tested using a macro-dilutional method, which involved combining it with 0.03% silver solution during the process of nanoparticle synthesis and then introducing it to the bacteria. A positive control containing the bacteria minus the nanoparticles extract was also prepared. 25 mg/mL, 12.5 mg/mL, and 6.25 mg/mL concentrations of the samples were produced using the macro dilution method. After adding the bacteria to multiple concentrations of nanoparticle extract, the suspensions were incubated for 24 h at a temperature of 37 °C. The suspensions were then spread on Mueller-Hinton agar (K. pneumonia) and chocolate blood agar (H. influenza), where the growth of bacteria was observed after 24 h. Nanoparticle extract in combination with silver at 0.03% was proven to have potential as an antimicrobial agent as it was able to inhibit H. influenza at all concentrations. Furthermore, it was also shown to be capable of inhibiting K. pneumonia at concentrations of 25 mg/mL and 50 mg/mL. In conclusion, the nanoparticle extract, when tested using a macro-dilutional method, displayed antimicrobial properties which were proven effective against the growth of both K. pneumonia and H. influenza.