bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Climate Impact Vary Across Time Horizons? A Time-frequency Analysis of Climate-crop Yields in India
Authors: Padakandla Steven Raj , Bhandari Avishek , Atluri Ajay Kumar 
Published: July 2021

Abstract
Climate change is a major concern the world over; more for a predominantly agrarian country like India. In this paper we analyze the time horizon dynamics of crop and climate variables at the regional level in India. We also analyze the co-movements between crop yields and temperature and rainfall to observe the coherence across heterogenous time horizons. We employ Bai-Perron structural break and Continuous wavelet transform methods on yearly data of seven crop yields and climate variables. Observed variables are analyzed over a period of 55 years from 1956-2011 for the un-divided state of Andhra Pradesh, India. The study shows that there is a steady and constant increase of around 1.00 in annual average, maximum and minimum temperatures in the state, with two observed break points at 1978 and 2002. Rainfall depicts no systematic change with fluctuations being largely random. Wavelet based coherence analysis that map time-horizon specific dynamics of climate and crops with time periods exhibited significant co-movement between climatic and crop variable. Given shifts in climate patterns and subsequent shifts in co-movements across time horizons at the regional level, policy makers and crop scientists should design time specific and locally viable adaption and mitigation policies to tackle the impact of climate on crops and livelihoods.JEL Classification: C13, Q10, Q15, Q50, Q54
Optimization of Critical Parameters for Coating of Polymeric Nanoparticles With Plasma Membrane Vesicles
Authors: Yang Feipeng , Cabe Maleen , Sanchez Veronica , Langert Kelly 
Published: July 2021

Abstract
Top-down functionalization of nanoparticles with cellular membranes imparts nanoparticles with enhanced bio-interfacing capabilities. Initial methods for membrane coating involved physical co-extrusion of nanoparticles and membrane vesicles through a porous membrane; however, recent works employ sonication as the disruptive force to reform membranes around the surface of nanoparticles. Although sonication is widely used, there remains a paucity of information on the effects of sonication variables on coating efficiency, leading to inconsistent membrane coating across studies. In this work, we present a systematic analysis of the sonication parameters that influence the membrane coating. The results showed that sonication amplitude, time, temperature, membrane ratio, sample volume, and density need to be considered in order to optimize membrane coating of polymeric nanoparticles.
Subgroup Analysis Makes GOLD2019's New Comprehensive Assessment More Convincing：A Cross-Sectional Study in Hunan Province, China
Authors: Dai Zhongshang , Chen Yan , Zeng Huihui , Cui Yanan 
Published: July 2021

Abstract
Purpose: To estimate the severity of the disease in outpatients with chronic obstructive pulmonary disease (COPD) in Hunan Province, China and use the subgroup analysis to evaluate the reliability of Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019.Methods: COPD outpatients from 21 medical centers in Hunan Province, China were stratified into groups A–D, and group D patients were further stratified into subgroups D1–D3 according to the GOLD 2016 comprehensive assessment. Demography, clinical characteristics and medications were compared between groups. Results: In 1,017 COPD outpatients, the distribution from group A to D and subgroup D1 to D3 was 41 (4.0%), 249 (24.5%), 17 (1.7%), 710 (69.8%) and 214 (30.2%), 204 (28.7%), 292 (41.1%), according to GOLD 2016. The clinical characteristics of patients vary from group to group. Some patients in groups C–D regrouped to groups A–B were all C1 and D1 subgroups according to GOLD 2019. Comparing subgroup D1 with group B, group D, subgroup D2 and subgroup D3, it was found that the demography, clinical characteristics and medications of subgroup D1 were the closest to group B, according to GOLD 2016. Conclusion: The disease severity of outpatients with COPD in Hunan Province was more common in group B and D and patients in groups A– D had different demography, clinical characteristics and medications, according to the GOLD 2016. Subgroup analysis can explain to a certain extent that GOLD2019's new comprehensive assessment is more reasonable and reliable than GOLD 2016.
E3 Ubiquitin Ligase NEDD4 Regulates Estrogen Receptor Expression and Affects the Prognosis of Patients With Hormone Receptor-positive Breast Cancer
Authors: Natori Yutaka , Suga Junko , Tokuda Emi , Tachibana Kazunoshin , Imai Jun-ichi , Honma Reiko , Azami Yusuke , Noda Masaru , Sasaki Eisaku , Watanabe Shinya , Ohtake Tohru , Saji Shigehira 
Published: July 2021

Abstract
Background: Neural precursor cell expressed developmentally downregulated 4-1 (NEDD4) is an E3 ligase that leads to the degradation of proteins including estrogen receptor a (ER). The E3 ligase can be a predictive marker of response to hormone therapy. We evaluated whether the expression level of NEDD4 affects the prognosis of hormone receptor-positive breast cancer patients. To support our clinical results, the association of NEDD4 with ER in breast cancer cells was studied.Methods: We performed a retrospective cohort study enrolling 145 patients with hormone receptor-positive HER2-negative breast cancer with pathological stage 0–II. Their expression levels of NEDD4 mRNA were measured, and disease-free survival (DFS) and overall survival (OS) were evaluated. Additionally, we knocked down NEDD4 in ER-positive breast cancer cells, MCF-7. We evaluated the expression level of ER in the cells and sensitivity to hormone therapy.Results: Mean follow-up time was 6.2 years. Of 67 patients with high NEDD4 levels (high NEDD4 group) and 78 patients with low NEDD4 levels (low NEDD4 group), 97.0% and 94.9% of the patients received neoadjuvant/adjuvant hormone therapy, respectively. The hormone therapy included aromatase inhibitors and tamoxifen. DFS and OS of the low NEDD4 group were significantly longer than the high NEDD4 group (p = 0.049 and p = 0.023). Western blot revealed high ER expression in NEDD4 knockdown cells. Proliferation of NEDD4 knockdown cells without estradiol stimulation as a simulation of the aromatase inhibitor therapy was suppressed to 53.6% of that with estradiol stimulation, whereas proliferation of NEDD4-expressing cells was suppressed to only 76.9%. Proliferation of NEDD4 knockdown cells with exposure to estradiol and hydroxytamoxifen was suppressed to 57.9% of that without exposure to hydroxytamoxifen. In contrast, proliferation of NEDD4-expressing cells was suppressed to only 73.3%. Thus, these simulations of hormone therapy showed a significant decrease in proliferation of NEDD4 knockdown cells.Conclusion: Knockdown of NEDD4 in ER-positive breast cancer cells resulted in ER accumulation and high-sensitivity to hormone therapy. Hormone receptor-positive breast cancer patients with low expression of NEDD4 had favorable DFS and OS.
Collision Avoidance and Dynamic Sleep Scheduling Technique for Cluster Based Underwater Wireless Sensor Networks (UWSN)
Authors: Anuradha D. , Suresh S. , Muneeshwari P. 
Published: July 2021

Abstract
In UWSN, during clustering, there may be occurrence of intra cluster collision. In order to overcome this issue, in this paper, we propose to design protocol to efficiently handle the intra-cluster collisions and to design sleep-wake up scheduling scheme for the data aggregation. In this case, the cluster head coordinates with its cluster members to transmit (append) their data packets with partially overlapping transmission times. After the CH finishes transmitting its packets to the courier nodes, it starts to receive incoming appended packets from its members. It then sends the packet to its parent CH towards the sink applying data fusion and sending the aggregated packet in TDMA period based on the receiver oriented sleep scheduling scheme. By simulation results, we show that the proposed technique minimizes collision and transmission delay.
Impact of Relative T2-FLAIR Signal Intensity of Non-Enhancing Lesions Outside Residual Cavity in Early Follow-up MRI on Outcome of Lower Grade Gliomas
Authors: Yuan Tao , Gao Zhen , Wang Fei , Wang Tianda , Zhong Hongbo , Quan Guanmin 
Published: July 2021

Abstract
Purpose T2-Fluid attenuated inversion recovery (FLAIR)hyperintensityoutside the residual cavity is one of the important MRI features in lowergrade gliomas (LGG), but its prognostic value needs to be further explored. The purpose of thisstudy was to investigate whether the relative signal intensity of T2-FLAIR outside the residual cavity (rFLAIR) can improve survival predictionofpost-treatment LGG patients or not. Methods Clinical and pathological data, and early follow-up MR imaging of 152 patients with LGG were reviewed.We calculatedrFLAIRwith Image J software.Logistic analysiswas used to explore the significant clinicaland conventional MRI factors, and rFLAIR on progressionfree survival (PFS) and overall survival (OS).Different models were setup to predict survival prognosis of LGG. Results Higher rFLAIR (1.80±0.84) of non-contrast-enhancing lesionsoutside residual cavity was detected in progression group (n=80) than that (1.55±0.33) of non-progression group (n = 72) (P<0.001)after radiotherapy.Multivariate analysis showed that higher rFLAIR(>1.595), as well as thick-linear and nodular enhancement of the residual cavity wall, were independent factors for the poor PFS and OS (both P<0.05). The cut-offrFLAIRof 1.595 could be used to predict poor PFS(HR 0.27, 95%CI 0.17-0.42) and OS (HR 0.22，95%CI 0.12-0.40)(P<0.001).Areas under the ROC curve (AUCs) for predicting poor PFS: clinical model 0.726, conventional MRI model 0.672, clinical + conventional MRI model 0.760, clinical + conventional MRI + rFLAIR combined model 0.827; AUCs for predicting poorer OS: clinical model 0.799, conventional MRI model 0.735, clinical + conventional MRI model 0.843, clinical + conventional MRI + rFLAIR combined model 0.880.Conclusions Our preliminary results indicated that higherrFALIR (>1.595) of non-contrast-enhancing lesionsoutside the residual cavity can be used as a biomarker of poor survival of LGG. Moreover,rFLAIR is helpful to improve the survival prediction of post-treatment LGG patients.
The Impact of COVID-19 on College Students’ Physical Activity: A Protocol for Systematic Review and Meta Analysis
Authors: Ding Yunxia , Ding Song , Niu Jiali 
Published: July 2021

Abstract
Background: We aimed to conduct a meta-analysis to assess the impact of coronavirus disease 2019 (COVID-19) on college students’ physical activity.Methods: All cohort studies, comparing college students undertaking physical exercise at school before the COVID-19 pandemic and physical exercise at home during the COVID-19 pandemic will be included in this review. We will use index words related to college students, physical exercise and COVID-19 to perform literature searches in PubMed, Medline, Embase and CNKI databases, to include articles indexed as of June 20, 2021 in English and Chinese language. Two reviewers will independently select trials for inclusion, assess trial quality and extract information for each included trials. Primary outcomes are exercise frequency, duration and intensity and associated factors. Based on Cochrane assessment tool, we will evaluate the risk of bias of the included studies. Revman 5.3 will be used for heterogeneity assessment, data synthesis, subgroup analysis, sensitivity analysis and generating funnel-plots.Discussion: The stronger evidence about the impact of COVID-19 on college students’ physical activity will be provided, so as to better guide teaching practice.Systematic review registration: PROSPERO CRD42021262390.
Ampere-Oersted Field Splitting of the Nonlinear Spin-torque Vortex Oscillator Dynamics
Authors: Araujo Flavio Abreu , Chopin Chloé , de Wergifosse Simon 
Published: July 2021

Abstract
We investigate the impact of the DC current-induced Ampère-Oersted field on the dynamics of a vortex based spin-torque nano-oscillator. In this study we compare micromagnetic simulations performed using mumax3 and our analytical model based on the Thiele equation approach. The latter is improved by adding two important corrections to the Thiele equation approach. The first is related to the magneto-static contribution and depends on the aspect ratio of the magnetic dot. The second is a full analytical description of the Ampère-Oersted field contribution. The model describes quantitatively the simulation results in the resonant regime as well as the impact of the Ampère-Oersted field. Depending on the relative orientation of the vortex in-plane curling magnetisation (chirality) and the Ampère-Oersted field a strong splitting phenomenon appears in the fundamental properties (frequency and vortex position) of the nano oscillator. Thus, we show that the Ampère-Oersted field should not be neglected as it has a high impact on the spin-torque vortex oscillator dynamics.
Decolorization of Azodyes by Chemically and Biosynthesized ZnO Nanoparticles
Authors: Swain Jasmine , Kulkarni Padmashree , Manuel Suba 
Published: July 2021

Abstract
Dye contaminants in industrial effluents contribute significantly to environmental pollution. Conventional waste water treatment methods are expensive and energy consuming. These limitations could be overcome by the use of nanobioremediation processes. The present work was an effort to study decolorization of azodyes by ZnO nanoparticles (NPs). Rubine GDB (R-GDB) and Congo Red (CR) were the azodyes selected for the study. The ZnO NPs were successfully synthesized by chemical and biological methods. Chemical synthesis of ZnO NPs was carried out by co-precipitation method; biological synthesis was done using bacteria Bacillus subtilis. The synthesized nanoparticles were characterized by UV-Vis Spectroscopy, SEM and XRD. The UV spectrophotometer showed peaks in the range of 300-400 nm. SEM pictures indicated the presence of NPs in the size of 100nm-200nm. XRD results were analyzed on the basis of the peaks that were seen. EDX analysis showed the presence of Zn particles and oxygen particles majorly. Decolorization efficiency was evualated by calculating % decolorization by Meyer’s method. Chemically synthesized NPs showed maximum % decolorization of the R-GDB (89.058 %) and CR (88.888%). The biosynthesized NPs showed the least decolorization (R- GDB -18 % and CR 20.357 %). However, moderate percentages of decolorization of both the azodyes were observed when a combination of the NPs was used (R-GDB -36.072 % and CR- 39.824 %). Nanoparticles showed good potential for the decolorization of the azo dyes. With further optimization of the parameters the present findings show that dye decolorization by chemically synthesized ZnO NPs could be used as a probable nanobioremediation approach to treat wastewaters.
Changes in land use/ land cover and water balance components before and after dam construction in the Mono River Basin, West Africa
Authors: Houteta Djan'na Koubodana , Atchonouglo Kossi , Adounkpe Julien , Diwediga Badabaté , Lombo Yao , Kpemoua Kossi E. , Agboka Komi 
Published: July 2021

Abstract
The intergovernmental Panel on Climate Change has predicted sub-tropical region to be more vulnerable to the effects of Climate Change(CC). Additionally, to CC, land use and land cover (LULC) changes and dam contruction often neglected, plays and important role on the spatial and temporal distribution of water balance components(WBC) for agriculture production and socio-ecological equilibrium. The aim of this study wa sto analyze and compare the changes in LULC and WBC for the periode before Nangbeto dam construction (1964-1986) and the period after its construction (1988-2010) in the Mono River Basin(MRB). To this end, the study used mainly WBC extracted from the validated Soil and Water Assessment Tool and LULC data of the years 1975 and 2000 in the MRB to explore their temporal distributions and the link in their changes. The results showed that the mean monthly actual evapotranspiration, percolation, water yield, surface runoff, groundwater and lateral flow represent 51.05%, 17.53%, 15.93%, 9.43%, 5.67% and 0.42%, respectively of total water balance between 1964 and 1986. The same components represented 51.02%, 9.17%, 20.43%, 6.30%, 10.56% and 2.59%, respectively between 1988 and 2010. The contribution of these WBC in mean-annual (1964-1986) period were for actual evapotranspiration (31.33%), water yield (25.95%), percolation(17.67%), groundwater(14.71%), surface runoff (9.94%) and lateral flow (0.40%). Meanwhile, between 1988 and 2010, the contribution of actual evapotranspiration, water yield, percolation, groundwater, surface runoff and lateral flow are 49.85%, 19.97%, 11.17%, 10.34%, 6.15% and 2.52%, resepctively. The results showed that the peaks of the evapotranspiration, surface runoff, percolation and water yield appeared in September corresponding to a month after the maximum of rainfall in August. However, our more detailed analysis showed that a significant decrease of forest and savanna and increase of cropland let to a decrease in actual evapotranspiration and lateral flow over the second period of simulation compared to the first period of simulation over the MRB scale. These findings showed that sustainable management and conservation of natural vegetation is crucial for integrated water resource management and conservation in MRB.
Clean Energy Transformation Investigation and Carbon Emission Analysis in Existing Urban Settlements in China
Authors: Chen Wei , Li Qiong , Zhao Li , Zhang Simin , Zheng Shilin 
Published: July 2021

Abstract
Carbon peak and carbon neutrality have been incorporated into the ecological civilization construction and social development strategy in China. At the same time, the implementation of clean energy transformation in urban settlements only relies on the mandatory provisions in the transformation design standards for a long time, and the transformation effect is inconsistent with the actual transformation demands of residents, which is contrary to the original intention of improving the living environment. A clean energy transformation investigation was conducted in the existing urban settlements in China from July to August 2020 in order to study the influencing factors and demands of residents' transformation intention in the clean energy transformation. The influencing factors and demand of urban residents' clean energy transformation intention were analyzed according to different climate zones, multivariate logistic regression and binary logistic regression. Taking Shandong Province as a case, a specific analysis of residential energy consumption data in cold climate zones is carried out, and the peak of residential carbon dioxide is predicted under the condition of different annual replacement rates of clean energy power generation. The results show that the residents' intention index of clean energy transformation is the highest in hot summer and cold winter area. The low motivation of clean energy transformation intention mainly comes from low annual income and high cost of living energy consumption considering the influencing factors of urban residents' clean energy transformation intention. In contrast, the high motivation of clean energy transformation intention is mainly from the not popular user of clean energy. For the demand of clean energy transformation, residents in cold regions have clear demand for energy-saving transformation of external walls and air conditioning, etc. residents consumption can be achieved the carbon peak by 2030 only when the annual growth rate of clean electricity reaches more than 5%.
Selective inhibition of soluble TNF using XPro1595 improves hippocampal pathology to promote improved neurological recovery following traumatic brain injury in mice
Authors: Dixon Kirsty , Larson Katelyn , Damon Melissa , Randhi Rajasa , Nixon-Lee Nancy 
Published: July 2021

Abstract
BACKGROUNDSymptoms associated with traumatic brain injury (TBI) can be debilitating, and treatment without off-target side-effects remains a challenge. This study aimed to investigate the efficacy of selectively inhibiting the soluble form of TNF (solTNF) using the biologic XPro1595 in a mouse model of TBI. METHODSMild-to-moderate traumatic brain injury (CCI model) was induced in adult male C57Bl/6J mice, with XPro1595 (10 mg/kg, S.C.) or vehicle being administered in a clinically relevant window (60 minutes post-injury). The animals were assessed for differences in neurological function, and hippocampal tissue was analyzed for inflammation and glial reactivity, as well as neuronal degeneration and plasticity. RESULTSWe report that unilateral CCI over the right parietal cortex in mice promoted deficits in learning and memory, depressive-like behavior and neuropathic pain. Using immunohistochemical and Western blotting techniques, we observed the cortical injury promoted a set of expected pathophysiology’s within the hippocampus consistent with the observed neurological outcomes, including glial reactivity, enhanced neuronal dendritic degeneration (dendritic beading), and reduced synaptic plasticity (spine density and PSD-95 expression) within the DG and CA1 region of the hippocampus. These effects were prevented in the mice treated with XPro1595. CONCLUSIONOverall, we observed that selectively inhibiting solTNF using XPro1595 improved the pathophysiological and neurological sequelae of brain-injured mice, which provides support of its use in patients with TBI.
Investigating Source Identification and Quality of Drinking Water In Piwoyi Community of Federal Capital Territory, Abuja Nigeria.
Authors: Segun Afolabi Abiodun , Raimi Morufu Olalekan 
Published: July 2021

Abstract
Water is essential to sustain life, and a satisfactory supply must be readily available to promote health, prolong life expectancy and prevent diseases. This study assesses the sources and quality of drinking water in Piwoyi community of Federal Capital Territory, Abuja, Nigeria. Thirty-five (35) Boreholes and Two (2) Sachet water were identified sources of drinking water in Piwoyi Community. Six Samples (5 Boreholes and 1Sachet water) were selected at random and analyzed in the laboratory. The Physicochemical parameters examined include electrical conductivity (EC), pH, temperature, turbidity, dissolve oxygen (DO), chloride, total hardness, alkalinity, nitrate, calcium, magnesium, phosphate, phosphorous, sulphate, sodium, potassium, fluoride, bicarbonate, nitrate-nitrogen, nitrite, copper, iron and zinc; and Microbiological parameters include Coliforms, E-coli and Faecal Strep. The results of analysis shows significant concentration of physicochemical and microbiological parameters in the samples of water analyzed according to Nigerian Standard for Drinking Water Quality thereby makes the water unsafe for drinking. Drinking from these sources of water will pose serious health risk to the people of Piwoyi Community. Therefore, the study helps to identify the contaminated locations as well as assist to follow emerging remedial measures toward controlling the contamination source in the community. It also recommends continuous monitoring and enforcement of environmental violations, aggressive sensitization on water sanitation and hygiene; adequate purification of water at domestic level; and government support on potable water supply and establish reasonable management strategies for sustainable water quality protection toward protecting public health.