bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Prediction Model for Affinity of Drug-Target Interactions Based on Molecular Vibration and Overall System of Ligand-Receptor
Authors: wang xian rui , cao ting ting , jia cong min , tian xue mei , Wang Yun 
Published: June 2021

Abstract
Background: the study of drug-target interactions (DTIs) affinity plays an important role in safety assessment and pharmacology. Currently, quantitative structure-activity relationship (QSAR) and molecular docking (MD) are most common methods in research of DTIs affinity. However, they often built for a specific target or several targets and most QSAR and MD were based either only on structure of drug molecules or on structure of targets with low accuracy and small scope of application. How to construct quantitative prediction models with high accuracy with wide applicability remains a challenge. To this end, this paper screened molecular descriptors based on molecular vibrations and took molecule-target as a whole system to construct prediction model with high accuracy-wide applicability based on Kd and EC50, and to provide reference for quantifying affinity of DTIs.Methods: Through parametric characterization based on molecular vibrations and protein sequences, taking molecule-target as whole system and feature selection of drug molecule-target, we constructed feature datasets of DTIs quantified by Kd and EC50, respectively. Then, prediction models were constructed using above datasets and SVM, RF and ANN. In addition, optimal models were selected for application evaluation and comprehensive comparison.Results: Under ten-fold cross-validation, evaluation parameters based on RF for EC50 dataset are as follows: R2 (RF) of training and test sets are 0.9611, 0.9641; MSE (RF) of training and test sets are 0.0891, 0.0817. Evaluation parameters based on RF for Kd dataset are as follows: R2 (RF) of training and test sets are 0.9425, 0.9485; MSE (RF) of training and test sets are 0.1208, 0.1191. After comprehensive comparison, the results showed that RF model in this paper is optimal model. In application evaluation of RF model, the errors of most prediction results were in range of 1.5-2.0.Conclusion: Through screening molecular descriptors based on molecular vibrations and taking molecule-target as whole system, we obtained optimal model based on RF with more accurate-widely applicable, which indicated that selection of molecular descriptors associated with molecular vibrations and the use of molecular-target as whole system are reliable methods for improving performance of model. It can provide reference for quantifying affinity of DTIs.
An Interrater Reliability Study on the Gothenburg Obstetric Triage System- a New Obstetric Triage System
Authors: Lindroos Linnéa , Elden Helen , Karlsson Ove , Sengpiel Verena 
Published: June 2021

Abstract
Background Triage, identifying patients with critical and time-sensitive disorders, is an integrated process in general emergency medicine. Obstetric triage is more specialised, requiring assessment of both woman, fetus and labour status. Failure to identify severely ill obstetric patients has repeatedly led to maternal morbidity and mortality. Reliable triage systems, adapted to obstetric patients as well as local conditions, are thus essential. The study aims to assess the interrater reliability (IRR) of the Gothenburg Obstetric Triage System (GOTS). Methods Midwives (n=6) and registered nurses with no experience in managing obstetric patients (n=7), assessed 30 paper cases based on actual real-life cases, using the GOTS. Furthermore, a consensus group consisting of two midwives and two obstetricians, with extensive experience in obstetric care, determined the correct triage level in order to enable analysis of over- and undertriage. IRR was assessed, both with percentage of absolute agreement and with intra-class correlation coefficients (ICC) with 95% confidence intervals (CI). Results A total of 418 assessments were performed, comprising all five levels of acuity in the GOTS. Absolute agreement was found in 69.6% of the assessments. The overall IRR was good, with a Kappa value of 0.78 (0.69 – 0.87, 95% CI) for final triage level. Comparison with consensus group assessments established that over- and undertriage had occurred in 9% and 21% of the cases, respectively. The main reasons for undertriage were “not acknowledging abnormal vital sign parameters” and “limitations in study design”. Conclusion The GOTS is a reliable tool for triaging obstetric patients. It enables a standardized triage process unrelated to the assessors’ level of experience in assessing and managing obstetric patients and is applicable for triaging obstetric patients presenting for emergency care at obstetric or emergency units.
Cross-Training Needs Among Community-Based Clinicians in HIV and Substance Use
Authors: Claborn Kasey , Scott Kelli , Becker Sara J 
Published: June 2021

Abstract
Background: People with double burden of HIV and substance use have poorer treatment engagement and worse treatment outcomes. Cross-training of HIV and substance use disorder clinicians can potentially enhance the scale up and quality of integrated care. Research is needed on clinicians’ areas of greatest training need in order to inform training development. Methods: Data from semi-structured individual interviews with 16 HIV and 13 substance use disorder clinicians (N=29) examining clinician perspectives on their training needs were analyzed using thematic analysis. Results: Overall, three themes emerged in regards to the clinicians’ need for training: 1) past training experiences: both HIV and substance use clinicians reported they had received minimal formal cross-training; 2) gaps in training: sensitivity and anti-stigma training, the latest medications for opioid use disorder and HIV prevention/treatment and referral resources emerged as key areas of cross-training need; and 3) training and supervision format/structure: clinicians cited didactic workshops and ongoing supervision as appealing strategies. Conclusions: Results show that lack of formal and updated training for clinicians is an important gap in providing integrated HIV and substance use treatment. Didactic workshops and ongoing support strategies that address stigma, medications for HIV and substance use disorder, and referral resources are likely to be particularly valuable.
Ressourcen und Belastungen im Arbeitsfeld Schulassistenz: Eine explorative Interviewstudie mit Schulassistent*innen verschiedener Schulformen in NRW
Authors: Schindler Florian , Schindler Maike 
Published: June 2021

Schulassistenz gewinnt im schulischen Kontext zunehmend an Bedeutung. Die Beschäftigungszahlen nehmen kontinuierlich zu, jedoch erfolgt die Leistungserbringung häufig unter augenscheinlich ungünstigen Bedingungen. Dabei sind die Arbeitsbedingungen, insbesondere Belastungen und Ressourcen im Arbeitsfeld Schulassistenz, weitgehend unerforscht. Der vorliegende Beitrag stellt eine qualitativ-explorative Interviewstudie mit acht Schulassistent*innen vor, in deren Rahmen die von den Schulassistent*innen wahrgenommenen Belastungen und Ressourcen ihres Arbeitsfeldes untersucht wurden. Basierend auf umfangreichem Interviewmaterial konnten verschiedene Faktoren von Belastungen und Ressourcen im Arbeitsfeld Schulassistenz herausgearbeitet werden. So erwies sich z. B. eine unzureichende organisationale Sozialisation als Belastungsfaktor, während aufgabenbezogene Kooperation und soziale Unterstützung als Ressourcen identifiziert wurden. Der Beitrag gibt einen Überblick über die gefundenen Faktoren von Belastungen und Ressourcen bei Schulassistent*innen, thematisiert mögliche Auswirkungen in Arbeitstätigkeiten und ordnet diese theoretisch und bezogen auf das Forschungsfeld ein.Abstract
Teaching assistance in Germany (so-called “school assistance”) is gaining increasing significance in the school context. Employment figures of teaching assistants are growing continuously, whereas the teaching assistants’ working conditions are apparently unfavorable in many cases. However, previous research has not yet addressed teaching assistants’ working conditions sufficiently: In particular, the occupational resources and demands in their work area are largely unexplored. This article presents a qualitative-explorative interview study with eight teaching assistants, which investigates what occupational resources and demands teaching assistants perceive in their work area. Based on extensive interview data, we identified various burdensome as well as advantageous factors. For example, a lack of organizational socialization was perceived as occupational demand, whereas collaboration und social support were perceived as resources. This article gives an overview of factors of occupational resources and demands in the work area of teaching assistants, it addresses the factors’ potential impact on the teaching assistances’ work, and sorts them theoretically and with respect to previous research.
Rekonstruktion und Inklusion – Perspektiven und Spannungsfelder rekonstruktiver Inklusionsforschung in der Erziehungswissenschaft
Authors: Köpfer Andreas 
Published: June 2021

Dieser Beitrag nimmt die Verfasstheit erziehungswissenschaftlicher Inklusionsforschung zum Ausgangspunkt, die bislang wesentlich auf ‚enge‘ und ‚weite‘ Verständnisse rekurriert, und erweitert diese um die Dimension von Personen- und Strukturbezug. Eine erziehungswissenschaftliche Inklusionsforschung, die eine Operationalisierung entlang von Personenkategorien in Frage stellt, ist jedoch auf Forschungszugänge angewiesen, die (immanente) Praktiken, Strukturen und Kulturen und darin eingelagerte Prozesse von Inklusion/Exklusion sichtbar machen.

Abstract
This article deals with inclusive education research and discusses dimensions and perspectives how inclusive education can be operationalized. It focuses on reconstructive methodologies and investigates its interconnection to the analysis of inclusive/exclusive practices, structures and cultures. It concludes with ambivalences and limitations of reconstructive research in inclusive education.
Enhanced biological control of root-knot nematode, Meloidogyne incognita, by combined inoculation of cotton or soybean seeds with a plant growth-promoting rhizobacterium and pectin-rich orange peel
Authors: Hassan Mohammad K. , Lawrence Kathy S. , Sikora Edward J. , Liles Mark R. , Kloepper Joseph W. 
Published: June 2021

Abstract
LC-MS analysis of plant growth-promoting rhizobacterium (PGPR) Bacillus velezensis AP203 supernatants indicated the presence of nematode-inhibiting compounds that increased in abundance when B. velezensis AP203 was grown on orange peel. Meloidogyne incognita J2 were incubated with B. velezensis AP203 spores and orange peel, spores alone, orange peel alone, or with a non-inoculated control, and the combination of B. velezensis AP203 with orange peel resulted in 94% mortality of M. incognita juveniles (p ≤ 0.05). The J2 mortality rate for B. velezensis alone was 53%, compared to 59% mortality with orange peel, and the non-inoculated control exhibited 7% mortality. When tested on soybeans raised in a greenhouse, it was observed that when grown in the presence of orange peel, B. velezensis AP203 culture broth, cell suspension or supernatant reduced the numbers of M. incognita eggs per g of root at 45 days after planting (DAP) compared to inoculated controls in soybean and cotton (p ≤ 0.05). Likewise, soybean root length and fresh root weight significantly increased after inoculation with B. velezensis AP203 amended with orange peel. In cotton, shoot and root length significantly increased after inoculation with cell pellets of B. velezensis AP203 amended with orange peel compared to the M. incognita inoculated control. These data indicate that B. velezensis AP203 responds to growth on pectin-rich orange peel by production of biologically active secondary metabolites that can promote plant growth and inhibit root-knot nematode viability.
Virtual Sphere: A Site to Negotiate the Image of Lengger Banyumas
Authors: Fatmawaty Lynda Susana Widya Ayu , Alim Condro Nur 
Published: June 2021

The research aimed at investigating how Lengger used the virtual sphere to negotiate their image to society. LenggerBanyumas was always stereotyped with the discourse of Queer, Gay, Bisexual, and Transgender (QGBT). Therefore, it ledto gender discrimination, not only on the stage but also in their daily life. Consequently, in this 4.0 era, Lengger neededto use social media in order to create a different image as an alternative way to negotiate the dancer’s gender identity.The method applied was Hine’s virtual ethnography method by applying Habermas theory. Respondents were interviewed virtually through video conference. Meanwhile, the data were collected through their Instagram. The results show that Lengger constructs their image on social media to produce an image by performing double-identity; they are feminine on the stage and masculine in real life. The first identity is a feminine dancer to reveal the image of a professional drag dancer from Banyumas. However, Lengger elaborates the masculine identity in their dance performance by wearing the attribute of female dancers. Meanwhile, Lengger also reveals masculine identity in their real life. As identity is fluid, it indicates that the image will also never be fixed. Thus, this image is reproduced constantly in the virtual sphere as a negotiation towards society’s stereotyping.
Gender Prediction for a Multiethnic Population via Deep Learning Across Different Retinal Fundus Photograph Fields: Retrospective Cross-sectional Study
Authors: Betzler Bjorn Kaijun , Yang Henrik Hee Seung , Thakur Sahil , Yu Marco , Quek Ten Cheer , Soh Zhi Da , Lee Geunyoung , Tham Yih-Chung , Wong Tien Yin , Rim Tyler Hyungtaek , Cheng Ching-Yu 
Published: June 2021

Background
Deep learning algorithms have been built for the detection of systemic and eye diseases based on fundus photographs. The retina possesses features that can be affected by gender differences, and the extent to which these features are captured via photography differs depending on the retinal image field.

Objective
We aimed to compare deep learning algorithms’ performance in predicting gender based on different fields of fundus photographs (optic disc–centered, macula-centered, and peripheral fields).

Methods
This retrospective cross-sectional study included 172,170 fundus photographs of 9956 adults aged ≥40 years from the Singapore Epidemiology of Eye Diseases Study. Optic disc–centered, macula-centered, and peripheral field fundus images were included in this study as input data for a deep learning model for gender prediction. Performance was estimated at the individual level and image level. Receiver operating characteristic curves for binary classification were calculated.

Results
The deep learning algorithms predicted gender with an area under the receiver operating characteristic curve (AUC) of 0.94 at the individual level and an AUC of 0.87 at the image level. Across the three image field types, the best performance was seen when using optic disc–centered field images (younger subgroups: AUC=0.91; older subgroups: AUC=0.86), and algorithms that used peripheral field images had the lowest performance (younger subgroups: AUC=0.85; older subgroups: AUC=0.76). Across the three ethnic subgroups, algorithm performance was lowest in the Indian subgroup (AUC=0.88) compared to that in the Malay (AUC=0.91) and Chinese (AUC=0.91) subgroups when the algorithms were tested on optic disc–centered images. Algorithms’ performance in gender prediction at the image level was better in younger subgroups (aged <65 years; AUC=0.89) than in older subgroups (aged ≥65 years; AUC=0.82).

Conclusions
We confirmed that gender among the Asian population can be predicted with fundus photographs by using deep learning, and our algorithms’ performance in terms of gender prediction differed according to the field of fundus photographs, age subgroups, and ethnic groups. Our work provides a further understanding of using deep learning models for the prediction of gender-related diseases. Further validation of our findings is still needed.
Gaming Extractivism: Indigenous Resurgence, Unjust Infrastructures, and the Politics of Play in Elizabeth LaPensée’sThunderbird Strike
Authors: Kinder Jordan B. 
Published: June 2021

Background: Indigenous-led struggles against fossil fuel infrastructure in North America have become increasingly visible. These struggles occur on the ground as well as through cultural production that performs cultural resistance.Analysis: This article examines Anishinaabe, Métis, and settler-Irish media theorist and artist Elizabeth LaPensée’s video game Thunderbird Strike as a form of Indigenous cultural resistance to extractivism.Conclusion and implications: Thunderbird Strike expresses the necessity of halting the expansion of extractivism by inviting players to participate in the sabotage of unjust infrastructure. In asking players to enact the very forms of generative resistance that the game articulates at a narratological level, Thunderbird Strike reveals the possibilities for video games to prefigure the transition to a decolonial, post-extractive future.
The Content of Harmful and Potentially Harmful Constituents in Heated Tobacco Product: Systematic Review
Authors: Hidayat Shoim , Alayyannur Putri Ayuni 
Published: June 2021

According to World Health Organization (WHO), most of health hazards due to smoking comes from exposure to cigarette smoke (smoke aerosol), formed from the burning process of tobacco in conventional cigarettes. This propels the implementation of the concept of tobacco harm reduction by striving for products for those still craving for tobacco can still consume, but at a lower risk. This study aims to determine the difference in HPHC content between conventional cigarettes and HTP. The research method used was literature review. In the preliminary stage, the researchers carried out a process of screening titles and abstracts from studies and then independently filtered the text papers completely according to the objectives of this study. The review yielded 22 journals meeting with the rules and regulations in this research. The results showed that all 9 HPHCs recommended for reduction (nine TobReg priority constituent) were shown to be 90% lower in HTP compared to conventional cigarettes. The conclusion was that there were differences in the HPHC content between conventional cigarettes and HTP.
Keywords: HPHC; HTP; Conventional Cigarettes
Bryonia Laciniosa An Ayurvedic Herbal Plant ‘Bryonia laciniosa’ with its Ethnomedicinal Significance
Authors: Kaurav Hemlata , Choudhary Shailja , Chaudhary Gitika 
Published: June 2021

Bryonia laciniosa is one such plant that is also known by the name of shivlingi as its seeds resemble the 'shivling' icon of Lord Shiva. This plant is mainly known for its seeds and is used in various ayurvedic drug formulations as an important ingredient. In Ayurveda and the folklore culture, shivlingi plant is used to treat various types of diseases such as cholera, bronchitis, constipation, diabetes, inflammation, paralysis, snake bites, abdominal diseases and mainly used as an aphrodisiac agent. In homeopathy, the B. laciniosa plant is used as an important ingredient in the formulation of anti-inflammatory drugs. Also, the plant is used to treat gastrointestinal, rheumatic, respiratory, liver, infectious diseases and metabolic disorders Besides this, shivlingi plant is associated with therapeutic potential which includes analgesic, antidiabetic, antioxidant, androgenic, antitumor, fertility and antipyretic properties. In this review article, the reported pharmacological properties of the plant have been described along with the plant utilization in folklore and ayurvedic medicinal system.
Keywords: Ayurveda, Shivlingi, Folk view, Pharmacological properties
Master Limited Partnership Research in Accounting, Economics, and Finance
Authors: Mandell Aaron J. 
Published: June 2021

ABSTRACT
I review the research on master limited partnerships (MLPs) in the accounting, economics, and finance literature. I begin by outlining the scope of the review and providing a brief background on the structure, taxation, and governance of master limited partnerships. Next, I describe the various sources from which MLP data are derived. I then review the research, aggregating it into four broad categories: (1) taxes and organizational form; (2) taxes, capital structure, and payout policy; (3) valuation; and (4) governance research. Within each section, I present possible avenues for future research in accounting, economics, and finance.
PERANCANGAN SISTEM INFORMASI PERPUSTAKAAN BERBASIS WEB DAN SMS GATEWAY DI SMA NEGERI 3 PADANG
Authors: Yanti Fitri , Huda Yasdinul , Hadi Ahmaddul 
Published: June 2021

Senior High School number 3 in Padang is International Standard School Stubs, which began seriously in optimizing library information system in order to improve competence. Witg the developments of information system book online library that uses PHP and SMS Gateway can make it easier for members to borrow of books. The library information system can also facilitate admin in arranging the books, borrowing, repayment and fines are all done by DBMS. In order to get accurate and precise reports. Hopes that there is this system can be a reference and cover all problems that exist in the library Senior High School number 3 in Padang. Keywords: Library Information System, Books, SMS Gateway
PENGARUH PENGGUNAAN MEDIA VISUAL GRAFIS FULL IMAGE AND COLOUR TERHADAP HASIL BELAJAR MEMAHAMI PRINSIP PEMBUATAN MASTER REKAMAN SISWA KELAS X TAV DI SMK NEGERI 2 SOLOK
Authors: Prabowo Aryo Widityo , Said Dharma Liza , Hadi Ahmaddul 
Published: June 2021

This study was conducted with the low background of student learning outcomes (of the 57 people who completed only 30 people, the remaining 27 have not reached the KKM is 70. Which affecting low learning outcomes one of which is due to the use of the media as a learning the theory process that does not fit. To see the effect of the use of instructional media with Media Visual Graphic full image and color , the research conducted in the form of experiments using with Media Visual Graphic full image and color. experimental type of research with Quasi exsperimental design shape design . study population was all class X TAV Academic Year 2012/2013 which amounts to 57 students in SMK Negeri 2 Solok . sampling technique used non - probability sampling , to sample class X TAV 1 totaled 28 people used the experimental class and class X TAV 2 classes totaling 29 persons used as controls . Results of experimental research using the media class with Media Visual Graphic full image and color has an average value ( 77.39 ) is higher than the control class that does not use with the Media Visual Graphic full image and color of ( 70.68 ) . Keywords : Learning Outcomes , Media , Media Visual Graphic full image and color