bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Italian Version of the ALS Depression Inventory-12
Authors: Pain Debora , Aiello Edoardo Nicolò , Gallucci Marcello , Miglioretti Massimo , Mora Gabriele 
Published: October 2021

Introduction: Depression is a comorbidity in patients with amyotrophic lateral sclerosis (ALS). However, its diagnosis is challenged by the co-occurrence of a similar frontotemporal (FT) behavioral symptom—i.e., apathy. Moreover, its psychometric evaluation is confounded by motor disabilities. This study aimed at investigating psychometric properties and feasibility of the ALS Depression Inventory (ADI-12), a self-report questionnaire set up for this issue—as measuring mood changes without referring to movement.Methods: Eighty-five ALS patients were administered the ADI-12 and underwent cognitive (Mini-Mental State Examination, MMSE), quality of life (McGill Quality of Life Questionnaire, MQoL) and further anxiety/mood (Hospital Anxiety and Depression Scale, HADS) assessments. Reliability, validity, sensitivity, and specificity of the ADI-12 were explored.Results: Principal component analyses revealed two related components—“Negative Mood and Lack of Energy” (ME) and “Anhedonia” (A). Both components and the inventory as a whole were internally consistent and highly related to HADS-D. ADI-12-total score was also associated with HADS-A. ADI-12 measures were inversely related to MQoL. ADI-12-total/sub-scales were not related to either MMSE or disease-related outcomes. Estimates of depression yielded by HADS-D and ADI-12 were 11.1 and 35.3%.Discussion: The ADI-12 is a valid, reliable and usable feasibile tool to assess depression in Italian ALS patients independently from motor disabilities. Its interplay with psycho-social outcomes is in agreement with previous studies. The lack of association with cognition suggests that the ADI-12 is partially independent from FT spectrum disorders. The disagreement in depression rates between the ADI-12 and HADS-D suggests the need to ALS-specific mood scales.
High Expression of Complement Component C7 Indicates Poor Prognosis of Breast Cancer and Is Insensitive to Taxane-Anthracycline Chemotherapy
Authors: Zhang Huikun , Zhao Yawen , Liu Xiaoli , Fu Li , Gu Feng , Ma Yongjie 
Published: October 2021

BackgroundBreast cancer is the most commonly diagnosed cancer worldwide. However, the well-known biomarkers are not enough to meet the needs of precision medicine. Novel targets are desirable and highly valuable for improved patient survival. In this regard, we identified complement component C7 as one of the candidates based on data from the OCOMINE database.MethodsC7 expression was examined by immunohistochemistry in 331 cases of invasive ductal carcinoma (IDC), 45 cases of ductal carcinomain situ(DCIS), and 52 cases of non-neoplastic tissues adjacent to tumor. Then, C7 expression was further confirmed by Western blot analysis based on IDC specimens and non-neoplastic breast specimens. The relationship between the C7 expression and prognosis of breast cancer patients was analyzed in order to investigate the function of C7 in breast cancer patients. Meanwhile, we also analyzed the relationship between the C7 expression and prognosis of 149 patients treated with conventional TE (taxane and anthracycline)-based chemotherapy. Then, a cohort of patients (22 cases) treated with TE neoadjuvant chemotherapy was used to further confirm the relationship between the C7 expression and TE-based chemosensitivity.ResultsIn our present study, we reported for the first time that C7 was an independent prognostic factor of breast cancer and C7 expression of IDC tissues was higher than non-neoplastic tissues adjacent to tumor and DCIS. In a cohort of 331 IDC patients, high expression of C7 indicated poor prognosis especially in the triple negative subtype and luminal B subtype. Furthermore, C7 was also a promoting factor for triple negative subtype patients to develop bone metastasis. Meanwhile, we provided the first evidence that patients with high C7 expression were insensitive to TE (taxane and anthracycline)-based chemotherapy by analyzing a cohort of 149 patients treated with TE-based chemotherapy and another cohort of 22 patients treated with TE neoadjuvant chemotherapy.ConclusionsIn summary, high expression of C7 may promote breast cancer development and might be insensitive to TE-based chemotherapy. Our present study laid a foundation to help clinicians improve the identification of patients for TE-based chemotherapy by C7 in the era of precision medicine.
Goal Management Training and Computerized Cognitive Training in Depression—a 2-Year Follow-Up of a Randomized Controlled Trial
Authors: Hagen Bjørn Ingulfsvann , Stubberud Jan 
Published: October 2021

Objective:Information on the long-term effects of cognitive remediation (CR) in major depressive disorder (MDD) is lacking. The present study reports 2-year follow-up data from a previously published randomized controlled trial (RCT) from our research group, comparing Goal Management Training (GMT), a strategy-based CR intervention, to drill-and-practice computerized cognitive training (CCT). In previous work, we found comparable improvements in executive function (EF), in addition to reductions in depressive symptoms, following both GMT and CCT at 6-month follow-up.Methods:Forty-two participants of the RCT, all diagnosed with MDD, were invited to complete rating-scales pertaining daily-life EF, rumination, and depressive symptoms. Explorative analyses compared the 2-year follow-up with previously published baseline and 6-month follow-up data, using non-parametric statistics. Similarly, GMT and CCT were compared at the 2-year follow-up, and completers were compared with non-completers.Results:Twenty participants completed the study. Overall, completers (n= 20) and non-completers (n= 22) were similar. There were no significant differences between GMT (n= 11) and CCT (n= 9) for any outcome 2 years post-treatment. Reduction compared to baseline in depressive symptoms and rumination, but not in daily-life EFs, emerged for GMT only.Conclusions:Findings suggest long-term improvements in mental health following GMT, while improvements in everyday EFs might require additional treatment or maintenance to sustain. Caution is warranted in the interpretation due to the small sample size and high attrition rates.
Numerical Simulation of Solar Air Heater using Paraffin Wax-Aluminum Compound as Phase Changing Material
Authors: Kumar Atul , Bhandari Prabhakar , Rawat K.S. 
Published: October 2021

This paper presents a theoretical investigation of solar air heater using phase change material (PCM). PCM used in present configuration is homogenous mixture of paraffin wax with Aluminium powder. The purpose of using Aluminium powder with paraffin wax is to increase the thermal conductivity. PCM mixtures are encapsulated in cylinders and are used as solar absorbers. Using MATLAB program, the effect of different parameters is studied. It has been observed that with increase in mass flow rate, air outlet temperature decreases and freezing time of cylinder decreases. However, at constant mass flow rate, with increase in cylinder radius, air temperature decreases and while freezing time increase sharply. The different parameters have to be chosen such that performance of solar air heater can be optimized.
Influence of Post Covid Change In Consumer Behaviour of Millennials On Advertising Techniques and Practices
Authors: Rashi Prakriti , Ankur Singh Bist  , Ari Asmawati  , Mukti Budiarto  , Yustika Prihastiwi Wahyu 
Published: October 2021

The pandemic caused by Covid 19 has kicked off survival strategies from vulnerable groups of people to small businesses, which has challenged the core operating practices and modified consumption patterns. Thus, effective marketing strategies are imperative in these times, that not only convey values of the brand but also resonate with people. Market disruptions are most likely to impact millennials and Gen Z and given the exploration and spending propensity, millennials are most likely to drive demand during the pandemic as well as in the post pandemic world. This research proposal aims to explore how consumer habits have changed during pandemic, how likely these habits will stick in the post pandemic world and how advertising needs to be transformed which relates best with millennials. The methodology involves a detailed analysis of literature and gathering insights from social media sites through big data. This research investigates the impact of avoiding deterministic automatisms purchasing processes, implying the need to understand, from an academic and conceptual standpoint, the utility of the set of business strategies to truly influence consumer purchasing behaviour of Millennials.
Exploration of Islamic Religious Learning Innovation Technology with the iLearning Approach
Authors: Haryani Hendriyati , Astriyani Erna , Devana Viola Tashya 
Published: October 2021

The field of education has an important role for a country in producing high-quality young generations so that they can be responsible for advancing the country. This important role is in line with the function of education, which is to develop abilities and shape the character and civilization of a dignified nation in order to educate the nation's life. Seeing the importance of education for the nation's next generation, it is necessary to innovate quality learning methods from childhood education to education in lectures. In this study, it will focus on improving the quality of learning methods, especially in Islamic religious lessons with the approach ilearning -which has been intensively developed for several years. Researchers will explore learning application innovations with an assessment focus seen from the feasibility component of learning applications, with the resulting structure covering 4 factors: Parental control, contribution to development skill, efficiency and motivation.
In this study, the assessment will be carried out by means of interviews in the form of a questionnaire to 100 data and the population calculation method, namely slovin, will be used in this study. The results of this study found an innovative learning application that meets the four assessment criteria. In this study, the dojo application has met 4 learning application assessment criteria by successfully occupying the first position in the four assessment categories. The assessment of parental control gets a percentage of 47%, the assessment of the role of skill development factors gets a percentage of 28%, the efficiency factor gets a percentage of 31% and the last assessment factor is the motivation factor where in the assessment of this factor the dojo application gets a percentage of 31%. Judging from this assessment, the dojo application can be stated as an application that is close to the learning application criteria in accordance with 4 (four) important factors in a learning application.
Programa Rede Comunitária: integrando saberes sociais e acadêmicos para o desenvolvimento humano
Authors: Queiroz Silvia Maria Prado Lopes , Schmidlin Claudir , Girata Doriana Gaio , Vettorazzi Maria Lúcia 
Published: October 2021

O Programa de Extensão Rede Comunitária do Câmpus Curitiba do Instituto Federal do Paraná (IFPR), atuou com crianças e adolescentes em situação de vulnerabilidade social, realizando oficinas sócio educativas semanais no contra turno escolar. O objetivo desta ação foi contribuir para o desenvolvimento humano, social e educacional das crianças, adolescentes e educadores de projetos sociais, bem como dos alunos e docentes do IFPR, promovendo a integração de saberes e práticas.DOI: http://dx.doi.org/10.35700/ca.2016.ano3n4.p119-123.1892
Advantages of Green Innovations and Technologies
Authors: Madona Kantidze Madona Kantidze 
Published: October 2021

The aim of the research is to explore the benefits of green innovations and technologies in the natural, economic and social environment.
As for the methodology, the article presents an empirical study. The reports of the European Union and the World Bank are reviewed, as well as the relevant conclusions are made based on the results of a research conducted in China, the analysis of the reforms adopted in Malaysia and the experience of Georgia.
Based on the reviewed reports and researches, we can conclude that green innovations and technologies have the following advantages:
	Contributes significantly to the risks of destruction of the environment, natural resources, flora and fauna;
	Allows businesses to use natural resources more efficiently, which decrease as time goes on;
	Promotes the development of a new, renewable energy field, which will significantly replace non-renewable energy;
	Green innovations and technologies help countries save non-renewable energy (for example, hybrid cars, help us save fuel);
	Gives business companies a competitive advantage (for example, countries that have promoted the idea of wind turbines have acquired a significant competitive advantage);
	Promotes the circular economy by increasing the life cycle of a product by reusing, renewing, repairing, or recycling it.
Keywords: green, innovations, technologies, environment, protection.
Rapid Radical–Radical Induced Explosive Desorption of Ice-coated Interstellar Nanoparticles
Authors: Zhu Cheng , Bergantini Alexandre , Singh Santosh K. , Abplanalp Matthew J. , Kaiser Ralf I. 
Published: October 2021

Abstract
The observation of complex organic molecules (COMs) in the gas phase of cold molecular clouds has coined a freeze-out paradox in astrophysics: COMs should be accreted on low-temperature interstellar grains, but not observable in cold molecular clouds. Still, validated mechanisms transporting molecules from the grains back into the gas phase are still elusive, but critical for our understanding of the chemical evolution of the molecular universe. Here we report on the first characterization of rapid radical reactions involving methyl (CH3) and formyl (HCO) radicals in interstellar analogous ices of methane (CH4) and carbon monoxide (CO) upon exposure to proxies of galactic cosmic rays. Rapid radical chain reactions and explosive desorption occurred once the accumulated radicals surpassed critical concentrations of about 1% in the ices at temperatures of cold molecular clouds (5–10 K). These processes may explain the ejection and observation of COMs in the gas phase of cold molecular clouds and potentially rapid outbursts of comets.
Predicting the Magnetic Fields of a Stealth CME Detected by Parker Solar Probe at 0.5 au
Authors: Palmerio Erika , Kay Christina , Al-Haddad Nada , Lynch Benjamin J. , Yu Wenyuan , Stevens Michael L. , Pal Sanchita , Lee Christina O. 
Published: October 2021

Abstract
Stealth coronal mass ejections (CMEs) are eruptions from the Sun that are not associated with appreciable low-coronal signatures. Because they often cannot be linked to a well-defined source region on the Sun, analysis of their initial magnetic configuration and eruption dynamics is particularly problematic. In this article, we address this issue by undertaking the first attempt at predicting the magnetic fields of a stealth CME that erupted in 2020 June from the Earth-facing Sun. We estimate its source region with the aid of off-limb observations from a secondary viewpoint and photospheric magnetic field extrapolations. We then employ the Open Solar Physics Rapid Ensemble Information modeling suite to evaluate its early evolution and forward model its magnetic fields up to Parker Solar Probe, which detected the CME in situ at a heliocentric distance of 0.5 au. We compare our hindcast prediction with in situ measurements and a set of flux-rope reconstructions, obtaining encouraging agreement on arrival time, spacecraft-crossing location, and magnetic field profiles. This work represents a first step toward reliable understanding and forecasting of the magnetic configuration of stealth CMEs and slow streamer-blowout events.
Mapping the 3D Kinematical Structure of the Gas Disk of HD 169142
Authors: Yu Haochuan , Teague Richard , Bae Jaehan , Öberg Karin 
Published: October 2021

Abstract
The disk around HD 169142 has been suggested to host multiple embedded planets due to the range of structures observed in the dust distributions. We analyze archival Atacama Large (sub-) Millimetre Array observations of 12CO (2–1), 13CO (2–1), and C18O (2–1) to search for large-scale kinematic structures associated with other embedded planets in the outer disk. At 125 au, we identify a coherent flow from the disk surface to the midplane, traced by all three CO isotopologues, and interpret it as a meridional flow potentially driven by an embedded planet. We use changes in the rotation speed of the gas to characterize the physical structure across this region, finding that at 125 au the CO emission traces regions of increased gas pressure, despite being at a surface density minimum. Developing a simple analytical model, we demonstrate that the physical structure of the gap can have non-trivial responses to changes in the surface density, consistent both with previous thermo-chemical models and the conditions inferred observationally. Applying this technique to a range of sources will allow us to directly confront theoretical models of gap-opening in protoplanetary disks.
Two Sites of r-process Production Assessed on the Basis of the Age-tagged Abundances of Solar Twins
Authors: Tsujimoto Takuji 
Published: October 2021

Abstract
Solar twins, i.e., stars that are nearly identical to the Sun, including their metallicities, in the solar vicinity show ages widely distributed from 0 to 10 Gyr. This fact matches the orbital history of solar twins in the new paradigm of galactic dynamics, in which stars radially move on the disk when they encounter transient spiral arms. This finding suggests that older twins were born closer to the Galactic center and traveled a longer distance to reach their present location, according to the hypothesis that chemical enrichment occurs more quickly and that solar metallicity is attained on a shorter timescale with a decreasing Galactocentric distance (R
GC). We show that abundance patterns covering a wide range of heavy elements for solar twins sharing similar ages are identical and that their variation among different age groups can be understood on the basis of the age–R
GC connection within the framework of Galactic chemical evolution. This study identifies the Galactic bulge as the birthplace of the oldest solar twins. Based on this scheme, we find that the relation between [r-process/Fe] and R
GC for the inner Galactic region is incompatible with the hypothesis of a sole site for r-process production, that is, neutron star mergers, whose delay time distribution could be approximated by the power-law form (∝ t

n
). Alternatively, this relation suggests the presence of two distinct sites for r-process production: short-lived massive stars, ending with specific core-collapse supernovae, and neutron star mergers that are heavily inclined to emerge with longer delay times, as represented by n = 0−0.5.
Analysis of Retinal Layers' Thickness and Vascular Density after Successful Scleral Buckle Surgery
Authors: Hassanpoor Narges , Milani Amir Eftekhari , Kordestani Alireza , Niyousha Mohamad Reza 
Published: October 2021

Purpose:
To investigate retinal layers' thickness and vascular density after successful scleral buckle surgery using the optical coherence tomography angiography (OCTA) method.

Methods:
In this prospective interventional case-control study, 24 patients with macular-off rhegmatogenous retinal detachment (RRD) were included after performing successful reattachment by scleral buckling. Retinal layers' thickness and vascular density were assessed in the patients using the OCTA method compared to normal fellow eyes as controls 10 months postoperation.

Results:
Inner retinal layers showed no significant difference, but there was a significant reduction in outer central 1-mm retinal layers' thickness. Outer plexiform-Bruch's membrane (153.1 ± 24.3 μm vs. 166.2 ± 15.1 μm, P = 0.003) and ellipsoid zone to Bruch's membrane (51.25 ± 9.3 μm vs. 57.35 ± 3.8 μm, P = 0.009) were thinner in the operated eyes compared to fellow eyes. Vascular density within a 300 μm wide region around the foveal avascular zone (FAZ) (foveal density-300) was significantly lower in the detached eyes (46.28% ± 7.12% vs. 51.01% ± 4.73%, P = 0.016), however, there was no difference in superficial and deep vascular density at 1-mm central circle. Superficial parafoveal vascular density was lower in the operated eyes (46.24% ± 5.30% vs. 49.52% ± 5.93%, P = 0.026) with no significant difference in deep parafoveal vascular density (49.93 ± 4.29% vs. 51.88% ± 4.79%, P = 0.137). There was no difference in FAZ area and perimeter between the two groups.

Conclusions:
Complete recovery of retinal thickness and vascular density did not achieve in the patients with RRD even after 10 months of reattachment by scleral buckling surgery. Superficial capillary vascular density was more affected than deep vascular density almost in the parafoveal area.
Intensity-modulated radiotherapy in locally advanced head-and-neck cancers in elderly patients
Authors: Jain Neeraj , Jain Sakshi , Sharma Ramita , Sachdeva Kanchan , Kaur Amandeep , Rakesh Abhimanyu , Abrol Deepak , Sudan Meena 
Published: October 2021

Introduction:
Head and neck cancer is one of the most common malignancies in Indian males. Due to poor socioeconomic status, presentation is usually in advanced stage. Treatment option is limited to radiotherapy with or without chemotherapy. Intensity-modulated radiotherapy (IMRT) provides highly conformal dose distributions creating nonuniform spatial intensity using different segments in the beam. Concomitant chemoradiation is highly toxic in this age group.

Material and Methods:
During 2016–2017, 44 patients with locally advanced head-and-neck cancers were treated with a curative intent with IMRT. They were in the age range of 65–75. The median age was 69 years. Thirty five were male and nine were female. Histopathologically, all had squamous cell carcinoma. Stage wise, all were T3N2 or more. The standard technique of IMRT was used with sparing of organs at risk and defining treatment volumes: gross, clinical, and planning. Patients were assessed after 4 weeks of completion of treatment for response and toxicities.

Results:
Response vise, 14 patients achieved complete response, 28 patients had partial response, and 2 had stable disease. There was no treatment-related mortality. Six patients had treatment interruptions due to toxicity. Incidence of mucositis was of Grade 1–2 in all patients. No hematological toxicity was seen. Patients having dysphagia during treatment were given nasogastric feed.