bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethnic disparity in metabolic syndrome and related obesity and health behavior: a community study in Taiwan
Authors: Lin Chih-Ying , Hung Hui-Jung , Chung Chi-Jung , Huang Chia-Ti , Wu Trong-Neng , Chen Chiu-Ying 
Published: November 2021

Abstract
Background
As studies on ethnic disparities in metabolic syndrome and its risk factors in Taiwan are still rare, the aims of this study were: (1) to detect the differences in the rates of metabolic syndrome, obesity and health behaviors between two ethnic groups (indigenous Tsou and nonindigenous Han) living in the same area and with similar age and sex distributions; (2) to examine whether ethnicity per se plays a significant role in the occurrence of metabolic syndrome, while taking other risk factors including sociodemographic characteristics, obesity and health behaviors into consideration.

Methods
This is a cross-sectional study using data from a community survey conducted in Chiayi County in southwestern Taiwan. A frequency matching strategy by age and sex with a ratio of 1 (Tsou) to 3 (Han) was applied to select a comparable sample between both ethnic groups (667 Tsou and 2001 Han) from among the survey participants. Furthermore, participants with cardiometabolic diseases diagnosed before the surveyed day were excluded to avoid confounding any associated risk factors for developing metabolic syndrome (MS). A final analytic sample of 1482 remained. The used information included sociodemographic characteristics, medical histories, health behaviors, and the concentrations of triglycerides, cholesterol, and glucose.

Results
Indigenous Tsou had significantly higher rates of metabolic syndromes, obesity and unhealthy behaviors than their Han counterparts (MS: 54.0% vs. 29.1%, obesity: 54.0% vs. 23.2%, drinking alcohol: 17.5% vs. 13.6%, and higher intake of fried food: 6.4% vs. 4.4%), even though they were similar in age and sex distributions. The significant risk factors for subsequently developing MS included being indigenous Tsou (adjusted POR = 2.62, P < 0.001), older, single, and obese. Stratified analyses on the risk factors for developing MS by health behaviors and by obese problems also indicated increased risks of being indigenous Tsou.

Conclusions
There existed ethnic differences in the rates of metabolic syndrome, obesity, and health behaviors. Ethnicity per se did play a significant role in developing MS; in particular indigenous Tsou people had increased risks, suggesting possible biological reasons rooted in their origins that need further exploration. In addition, unhealthy behaviors may potentially have an indirect effect on developing MS via their effect on obesity.
Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
Authors: Baker Bernadette C. , Lui Sylvia , Lorne Isabel , Heazell Alexander E. P. , Forbes Karen , Jones Rebecca L. 
Published: November 2021

Abstract
Background
Current methods fail to accurately predict women at greatest risk of developing fetal growth restriction (FGR) or related adverse outcomes, including stillbirth. Sexual dimorphism in these adverse pregnancy outcomes is well documented as are sex-specific differences in gene and protein expression in the placenta. Circulating maternal serum microRNAs (miRNAs) offer potential as biomarkers that may also be informative of underlying pathology. We hypothesised that FGR would be associated with an altered miRNA profile and would differ depending on fetal sex.

Methods
miRNA expression profiles were assessed in maternal serum (> 36 weeks’ gestation) from women delivering a severely FGR infant (defined as an individualised birthweight centile (IBC) < 3rd) and matched control participants (AGA; IBC = 20–80th), using miRNA arrays. qPCR was performed using specific miRNA primers in an expanded cohort of patients with IBC < 5th (n = 15 males, n = 16 females/group). Maternal serum human placental lactogen (hPL) was used as a proxy to determine if serum miRNAs were related to placental dysfunction. In silico analyses were performed to predict the potential functions of altered miRNAs.

Results
Initial analyses revealed 11 miRNAs were altered in maternal serum from FGR pregnancies. In silico analyses revealed all 11 altered miRNAs were located in a network of genes that regulate placental function. Subsequent analysis demonstrated four miRNAs showed sexually dimorphic patterns. miR-28-5p was reduced in FGR pregnancies (p < 0.01) only when there was a female offspring and miR-301a-3p was only reduced in FGR pregnancies with a male fetus (p < 0.05). miR-454-3p was decreased in FGR pregnancies (p < 0.05) regardless of fetal sex but was only positively correlated to hPL when the fetus was female. Conversely, miR-29c-3p was correlated to maternal hPL only when the fetus was male. Target genes for sexually dimorphic miRNAs reveal potential functional roles in the placenta including angiogenesis, placental growth, nutrient transport and apoptosis.

Conclusions
These studies have identified sexually dimorphic patterns for miRNAs in maternal serum in FGR. These miRNAs may have potential as non-invasive biomarkers for FGR and associated placental dysfunction. Further studies to determine if these miRNAs have potential functional roles in the placenta may provide greater understanding of the pathogenesis of placental dysfunction and the differing susceptibility of male and female fetuses to adverse in utero conditions.
DockStream: a docking wrapper to enhance de novo molecular design
Authors: Guo Jeff , Janet Jon Paul , Bauer Matthias R. , Nittinger Eva , Giblin Kathryn A. , Papadopoulos Kostas , Voronov Alexey , Patronov Atanas , Engkvist Ola , Margreitter Christian 
Published: November 2021

AbstractRecently, we have released the de novo design platform REINVENT in version 2.0. This improved and extended iteration supports far more features and scoring function components, which allows bespoke and tailor-made protocols to maximize impact in small molecule drug discovery projects. A major obstacle of generative models is producing active compounds, in which predictive (QSAR) models have been applied to enrich target activity. However, QSAR models are inherently limited by their applicability domains. To overcome these limitations, we introduce a structure-based scoring component for REINVENT. DockStream is a flexible, stand-alone molecular docking wrapper that provides access to a collection of ligand embedders and docking backends. Using the benchmarking and analysis workflow provided in DockStream, execution and subsequent analysis of a variety of docking configurations can be automated. Docking algorithms vary greatly in performance depending on the target and the benchmarking and analysis workflow provides a streamlined solution to identifying productive docking configurations. We show that an informative docking configuration can inform the REINVENT agent to optimize towards improving docking scores using public data. With docking activated, REINVENT is able to retain key interactions in the binding site, discard molecules which do not fit the binding cavity, harness unused (sub-)pockets, and improve overall performance in the scaffold-hopping scenario. The code is freely available at https://github.com/MolecularAI/DockStream.
New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis
Authors: Theunissen Frances , West Phillip K. , Brennan Samuel , Petrović Bojan , Hooshmand Kosar , Akkari P. Anthony , Keon Matt , Guennewig Boris 
Published: November 2021

AbstractAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axonal projections, which rely on the integrity of neuronal cytoskeleton and mitochondria to regulate energy requirements for maintaining axonal stability, anterograde and retrograde transport, and signaling between neurons. The formation of protein aggregates which contain cytoskeletal proteins, and mitochondrial dysfunction both have devastating effects on the function of neurons and are shared pathological features across several neurodegenerative conditions, including ALS, Alzheimer's disease, Parkinson's disease, Huntington’s disease and Charcot-Marie-Tooth disease. Furthermore, it is becoming increasingly clear that cytoskeletal integrity and mitochondrial function are intricately linked. Therefore, dysregulations of the cytoskeletal network and mitochondrial homeostasis and localization, may be common pathways in the initial steps of neurodegeneration. Here we review and discuss known contributors, including variants in genetic loci and aberrant protein activities, which modify cytoskeletal integrity, axonal transport and mitochondrial localization in ALS and have overlapping features with other neurodegenerative diseases. Additionally, we explore some emerging pathways that may contribute to this disruption in ALS.
Individual tracking reveals first breeding of Oriental Storks at age 2 years in the wild
Authors: Sasin Anton , Serdyuk Anna , Zhu Baoguang , Zhao Qingshan 
Published: November 2021

AbstractIn this study, we report the first ever documented instances of attempted and successful reproduction (rearing two offspring) of Oriental Storks (Ciconia boyciana) at age 2 years in a wild population in the middle Heilongjiang-Amur River Basin in Russia, using a combination of GPS-GSM tracking, DNA sex identification and field verification.
Effect of Different Sports Practice on Sleep Quality and Quality of Life in Children and Adolescents: Randomized Clinical Trial
Authors: Rosa Camila Cassemiro , Tebar William Rodrigues , Oliveira Crystian Bittencourt Soares , Farah Breno Quintella , Casonatto Juliano , Saraiva Bruna Thamyres Ciccotti , Christofaro Diego Giulliano Destro 
Published: November 2021

Abstract
Background
Sports practice can promote several health benefits in pediatric populations; nonetheless, most of the studies that investigated these benefits are of cross-sectional design. Thus, our objective was to verify the effectiveness of two types of physical activities through sports, judo and ball games (soccer, volleyball, handball, and basketball) on the quality of sleep and life of Brazilian children and adolescents.

Methods
The study is a randomized clinical trial, conducted with 65 participants of both sexes (6–15 years old) in a philanthropic institution in Brazil. The variables investigated were the quality of sleep and life, using the mini-sleep questionnaire and KidsCreen-52 questionnaires (this instrument has a scale ranging from 0 to 100, where 100 is the best value for each domain), respectively. The interventions carried out during 12 weeks (twice a week) were judo and ball games. In the statistical analysis, analysis of variance (ANOVA) for repeated measures was used and the level of statistical significance used was 5%.

Results
Judo (P = 0.032) and ball games (P = 0.005) contributed to improving the quality of sleep in the participants. Considering the score of the domains of quality of life, judo and ball games significantly increased the perception of health and physical activity [mean = 6.9 (8.3%) and 8.91 (12.2%) points, respectively], autonomy [mean = 5.81 (7.3%) and 5.00 (6.9%) points], friends and social support (mean = 2.83 (3.8%) and 12.00 (15.9%) points), provocation and bullying [mean = 10.21 (18.1%) and 2.14 (4.1%) points].

Conclusion
It is concluded that both judo and ball games brought benefits to the quality of sleep and life of children and adolescents. Health promotion actions should encourage the increase in sports practice in children and adolescents to improve sleep and quality of life.
Predictors of stress among a sample of Egyptian healthcare providers during the COVID-19 pandemic
Authors: Shaker Nermin Mahmoud , Sabry Noha , Alkasaby Muhammad Abdullatif , Rabie Menan 
Published: November 2021

Abstract
Background
The COVID-19 pandemic had a tremendous effect on people’s mental health. Healthcare workers were on the front lines in response to this crisis; therefore, they were among the most affected by the pandemic. The study aims to assess the stress perceived by healthcare workers and possible factors contributing to it, hoping that more efforts will be exerted to support the well-being of healthcare workers during public health emergencies. A cross-sectional study using an online survey was conducted. Data were collected from 118 healthcare professionals working with COVID-19 patients during the peak of the first wave of the COVID-19 pandemic.

Results
Most of the respondents (75.2%) scored much higher stress levels than average, and 19.5% had slightly higher levels of stress. Most respondents were afraid of infecting their family and close ones (77.1 %), and about half of the respondents were afraid of getting infected (47.5%). Regression analysis revealed that the only significant independent variable predicting developing higher stress levels among the participants was assigning them to tasks outside their specialty.

Conclusions
Healthcare workers are at high risk of developing mental health problems during public health emergencies. Their well-being is essential for the quality of services they provide. More efforts are needed to ensure the well-being of healthcare workers and to prepare them for such emergencies. Preparing healthcare workers before redeployment through training and providing PPEs will help to reduce the negative impact of the COVID-19 pandemic on their physical and mental health.
Role of magnetic resonance imaging on fingers in diagnosis of post-traumatic tendon and ligament injuries
Authors: Abdellatif Hayam Abdelmonsif , El Aziz Maaly Mohammed Abd , Soltan Belal Said Hefny Ibrahim , Abduallah Mohammed Shawky 
Published: November 2021

AbstractBackgroundMagnetic resonance (MR) imaging is a powerful method for evaluating acute and chronic lesions of the stabilizing articular elements (volar plate and collateral ligaments) of the fingers and thumbs, the condition of tendons, the presence of a tear, the number of affected tendons, the extent of tendon retraction, and the presence of associated lesions. This study was done to clarify the value of magnetic resonance imaging (MRI) in assessment of trauma-related injuries of the tendons and ligaments of the fingers and subsequently positively affect the surgical decisions in such cases.ResultsThis study included 42 patients (33 males and 9 females) with a mean age of 35 years. All of them had history of trauma. Male affection was 78.5%, while females constituted only 21.5%, striking right-sided-hand affection (92.9%). The most affected finger was the thumb. The most common affected sites were extending from the metacarpophalangeal (MCP) till the proximal interphalangeal (PIP). The tendons were affected in 42.9%; meanwhile, ligamentous affection represented 57.2%. The flexor tendon tear represented by 28.6%%, while extensor tendon tear occurred in 14.3%. The study also showed that partial thickness tear is represented by 66.7%, while complete thickness tear occurred in about 33.3%. Bone marrow edema and post-traumatic tenosynovitis occurred in about 14% of cases.ConclusionsMagnetic resonance imaging is an essential technique to obtain a correct pre-surgical diagnosis. It is of utmost importance to possess an in-depth knowledge of finger radiological anatomy in detail, as well as the appearance of the different pathologic entities on MRI. It provides a great assessment of the tendons and ligaments tear by whether partial or complete, any associated marrow edema or bony fragment avulsion and the extent of retraction in cases of complete tear.
A novel approach of a dynamic multi objective optimization of a power distribution system
Authors: Ndjependa Patrik Roger , Boum Alexandre Teplaira , Essiane Salomé Ndjakomo 
Published: November 2021

AbstractA new dynamic multi objective optimization approach is covered in this paper. The technique for optimizing the power distribution system is dynamic reconfiguration. The goal is to propose an optimal dynamic reconfiguration which minimizes the active power losses and the voltage deviation of the nodes of the power distribution system according to the energy available at the source, while constantly guaranteeing the supply of the electrical energy to priority consumers. The reliability indices considered in this paper are the system average interruption frequency index (SAIFI) and the system average interruption duration index (SAIDI) and are used to check the reliability of the optimal configurations obtained. This study subdivides a day into periods. The variations in the available power of the source and the power requested by the load, cause a new optimal configuration of the network at each period. In this work, the load adapts to the source and the optimal network topology evolves according to the maximum available power of the source. A mathematical formulation of the dynamic optimization problem by period or piece is proposed. The dynamic approach consists in acquiring the power of the load and of the source by period or piece and to compare them. When the available energy is sufficient, an optimal configuration that minimizes the power losses and voltage deviation while ensuring the supply of electrical energy to all consumers in the network is proposed. On the other hand, when the available energy is insufficient, an optimal topology of the power system minimizing the power losses and voltage deviation while guaranteeing the supply of electrical energy to priority consumers of the network is proposed. The optimal solutions per period are obtained using the MIP and MINLP methods. The approach is implemented on standard IEEE 15, 33 and 69 node power distribution system. The results obtained are satisfactory and prove the effectiveness of this new vision for the conduct of the power distribution system.
Research on SARS-COV-2 pandemic: a narrative review focused on the Italian contribution
Authors: De Cassai Alessandro , Longhini Federico , Romagnoli Stefano , Cavaliere Fabio , Caroleo Antonio , Foti Lorenzo , Furlani Elisa , Gianoli Sara , Monteleone Francesco , Saraco Giuseppe , Villa Gianluca , Conti Giorgio , Navalesi Paolo 
Published: November 2021

Abstract
Background
Since late 2019, a severe acute respiratory syndrome, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread with overwhelming speed causing over 214 million confirmed infections and more than 4.5 million deaths worldwide. In this framework, Italy had the second highest number of SARS-CoV-2 infections worldwide, and the largest number of deaths. A global effort of both the scientific community and governments has been undertaken to stem the pandemic. The aim of this paper is to perform a narrative review of the Italian contribution to the scientific literature regarding intensive care management of patients suffering from COVID-19, being one of the first western countries to face an outbreak of SARS-CoV-2 infection.

Main body
We performed a narrative review of the literature, dedicating particular attention and a dedicated paragraph to ventilatory support management, chest imaging findings, biomarkers, possible pharmacological interventions, bacterial superinfections, prognosis and non-clinical key aspects such as communication and interaction with relatives.

Conclusions
Many colleagues, nurses and patients died leaving their families alone. To all of them, we send our thoughts and dedicate these pages.
The impact of equilibrium optimal flux deviation on traffic dynamics in lattice hydrodynamic model under V2X environment
Authors: Li Xiaoqin , Peng Guanghan 
Published: November 2021

Abstract
In this work, the equilibrium optimal flux deviation is explored as a control signal under the V2X environment via traffic modeling of the lattice hydrodynamic model. According to the control theory, the sufficient stable condition can be deduced. In addition, numerical simulation is implemented for the early time impact, the steady-state effect, and the hysteresis phenomenon of traffic flow with the increase of the feedback gain response to the equilibrium optimal flux deviation. The result demonstrates that the equilibrium optimal flux deviation effect has significantly positive influence on the stability of the traffic flow.
Women living with their mothers-in-law
Authors: Bietsch Kristin E , LaNasa Katherine H , Sonneveldt Emily 
Published: November 2021

Background Many studies have documented the impacts mothers-in-law have on daughters-in-law living in the same household, but few have quantified the scale of this co-residence. This study aims to estimate the proportion of married women living with their mothers-in-law across countries and time. Methods Using household rosters from 250 Demographic and Health Surveys in 75 countries, this paper uses the “relationship to head of household” question to identify households where married women live with their mothers-in-law. For select countries with large changes, we decompose changes in rates into changes in the age structure of married women and the rate of women living with their mothers-in-law by age. Results This paper finds large variation in family structure around the globe, from 1% of married women in Rwanda to 49% in Tajikistan living with their mother-in-law. Many countries with high co-residence in the 1990s continue to see high and increasing numbers today, especially in Central and Southern Asia, while some North and sub-Saharan African countries experienced substantial declines. Decomposing changes by age and rates shows that changes in the age structure of married women is not driving changes in co-residence, but rather the rates are changing across age groups. Conclusions These findings show the large variation in women living with their mothers-in-law across the globe. The authors provide publicly available code and future research ideas to encourage others to further our understanding of the impact of living with her mother-in-law on a woman’s life.