bluuebunny/crossref_metadata_2025_split huggingface dataset:
Input price discrimination by resale market
Authors: Miklós‐Thal Jeanine , Shaffer Greg 
Published: November 2021

AbstractThis article analyzes supply tariffs that discriminate between resale in different markets. In a setting with competing retailers that operate in multiple (independent or interdependent) markets, we show that, all else equal, a monopolist supplier wants to discriminate against resale in the market with the higher aggregate cross‐seller diversion ratio. We find that discrimination can improve allocative efficiency and present sufficient conditions, involving the pass‐through rates and the market demand curvatures in the different markets, under which discrimination has positive effects on output and welfare. Our insights are relevant for the policy treatment of vertical restraints on online sales.
“Only the orangutans get a life jacket”
Authors: CHUA LIANA , FAIR HANNAH , SCHREER VIOLA , STĘPIEŃ ANNA , THUNG PAUL HASAN 
Published: November 2021

ABSTRACTIn an era of mass extinction, who gets a life jacket, who is left to drown or swim—and on what basis? This article addresses these questions by analyzing how tropes and practices of responsibility are variously enacted, reworked, contested, and refused across the global nexus of orangutan conservation. Drawing on multisited, collaborative ethnography, we trace the mutually constitutive relation between multiple orangutan figures and commons imaginaries at different nodes of conservation—from environmental activism in the Global North to NGO‐villager encounters in rural Borneo. In so doing, we “uncommon” international conservation's encompassing planetary imaginaries, showing how dominant portrayals of the orangutan as a global responsibility are translated and fragmented in different settings. We further contemplate what an analytic of responsibility might bring to ongoing discussions about the “commoning” planetary epoch in which conservation is increasingly embedded: the Anthropocene. [commons, uncommoning, responsibility, orangutan conservation, the Anthropocene, Borneo, Indonesia]
Evaluating cut‐off levels for progesterone, β human chorionic gonadotropin and β human chorionic gonadotropin ratio to exclude pregnancy viability in women with a pregnancy of unknown location: A prospective multicenter cohort study
Authors: Bobdiwala Shabnam , Kyriacou Christopher , Christodoulou Evangelia , Farren Jessica , Mitchell‐Jones Nicola , Al‐Memar Maya , Ayim Francis , Chohan Baljinder , Kirk Emma , Abughazza Osama , Guruwadahyarhalli Bramara , Guha Sharmistha , Vathanan Veluppillai , Gould Debbie , Stalder Catriona , Timmerman Dirk , Van Calster Ben , Bourne Tom 
Published: November 2021

AbstractIntroductionThere is no global agreement on how to best determine pregnancy of unknown location viability and location using biomarkers. Measurements of progesterone and β human chorionic gonadotropin (βhCG) are still used in clinical practice to exclude the possibility of a viable intrauterine pregnancy (VIUP). We evaluate the predictive value of progesterone, βhCG, and βhCG ratio cut‐off levels to exclude a VIUP in women with a pregnancy of unknown location.Material and methodsThis was a secondary analysis of prospective multicenter study data of consecutive women with a pregnancy of unknown location between January 2015 and 2017 collected from dedicated early pregnancy assessment units of eight hospitals. Single progesterone and serial βhCG measurements were taken. Women were followed up until final pregnancy outcome between 11 and 14 weeks of gestation was confirmed using transvaginal ultrasonography: (1) VIUP, (2) non‐viable intrauterine pregnancy or failed pregnancy of unknown location, and (3) ectopic pregnancy or persisting pregnancy of unknown location. The predictive value of cut‐off levels for ruling out VIUP were evaluated across a range of values likely to be encountered clinically for progesterone, βhCG, and βhCG ratio.ResultsData from 2507 of 3272 (76.6%) women were suitable for analysis. All had data for βhCG levels, 2248 (89.7%) had progesterone levels, and 1809 (72.2%) had βhCG ratio. The likelihood of viability falls with the progesterone level. Although the median progesterone level associated with viability was 59 nmol/L, VIUP were identified with levels as low as 5 nmol/L. No single βhCG cut‐off reliably ruled out the presence of viability with certainty, even when the level was more than 3000 IU/L, there were 39/358 (11%) women who had a VIUP. The probability of viability decreases with the βhCG ratio. Although the median βhCG ratio associated with viability was 2.26, VIUP were identified with ratios as low as 1.02. A progesterone level below 2 nmol/L and βhCG ratio below 0.87 were unlikely to be associated with viability but were not definitive when considering multiple imputation.ConclusionsCut‐off levels for βhCG, βhCG ratio, and progesterone are not safe to be used clinically to exclude viability in early pregnancy. Although βhCG ratio and progesterone have slightly better performance in comparison, single βhCG used in this manner is highly unreliable.
Perceived needs for team‐based visits in Swedish child healthcare services exceed its existence—A mixed‐methods study targeting healthcare professionals
Authors: Nygren Ulrika Svea , Sandberg Håkan , Tindberg Ylva , Nordgren Lena , Eriksson Leif 
Published: November 2021

AbstractAimTo investigate both quantitatively and qualitatively the differences between participation in team‐based visits (TBVs) and perceived needs for TBVs from the perspectives of healthcare professionals, in the context of the Swedish 3‐tier national Child Healthcare programme.MethodsA study‐specific questionnaire, including multiple‐choice questions with fixed and free‐text response options, was developed, and used. To capture healthcare professionals' experiences and find explanations for the quantitative results in qualitative data, a convergent parallel mixed‐methods study design was used. Descriptive statistics and McNemar's test were used to analyse the quantitative data, and content analysis was used to analyse the qualitative data.ResultsHealthcare professionals perceived the need for TBVs in the Swedish Child Healthcare Services (CHS) to a high extent. The largest difference between the perceived need for TBVs and experienced TBVs was for indications associated with psychosocial problems. The quantitative findings were explored by the qualitative findings. Both individual and organisational factors influenced TBVs.ConclusionPerceived needs for TBVs in Swedish CHS exceed its existence. Healthcare professionals require TBVs delivered by interprofessional teams, in line with proportionate universalism. Accordingly, organisational structures (e.g. colocation and clear instructions on how to distribute TBVs) and human resources (e.g. psychologists and social worker) are needed.
Methyltransferase‐like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1
Authors: Liu Tao , Wang Hui , Fu Zhibin , Wang Zheng , Wang Jie , Gan Xinxin , Wang Anbang , Wang Linhui 
Published: November 2021

AbstractGrowing evidence supports that N6‐methyladenosine (m6A) modification acts as a critical regulator involved in tumorigenesis at the mRNA level. However, the role of m6A modification at the noncoding RNA level remains largely unknown. We found that methyltransferase‐like 14 (METTL14) was significantly downregulated in renal cell carcinoma (RCC) tissues (n = 580). Gain‐of‐function and loss‐of‐function experiments revealed that METTL14 attenuated the proliferation and migration ability of RCC cells in vivo and in vitro. The methylated RNA immunoprecipitation experiments identified that METTL14 decreased the expression of long noncoding RNA nuclear enriched abundant transcript 1_1 (NEAT1_1) in an m6A‐dependent manner. Mechanistically, RNA pull‐down assay and RNA immunoprecipitation identified NEAT1_1 directly bound to m6A reader YTH N6‐methyladenosine RNA binding protein 2 (YTHDF2). Notably, YTHDF2 accelerated the degradation of NEAT1_1 by selectively recognizing METTL14‐mediated m6A marks on NEAT1_1. Multivariate analysis suggested that METTL14 downregulation was associated with malignant characteristics and predicted poor prognosis in RCC patients. In conclusion, our results uncover a newly identified METTL14‐YTHDF2‐NEAT1_1 signaling axis, which facilitates RCC growth and metastasis and provides fresh insight into RCC therapy.
Coconstructing a Meaningful Online Environment: Faculty–Student Rapport in the English as a Foreign Language College Classroom
Authors: Almusharraf Norah 
Published: November 2021

AbstractRapport‐building is perceived to enhance engagement, level of gratification, and collaboration, resulting in better student engagement in the learning process. The current study measures the extent to which postsecondary instructors promote a meaningful online environment through faculty–student rapport (FSR) in undergraduate English as a foreign language (EFL) classrooms. This study is grounded on social constructivism and self‐determination theoretical frameworks, suggesting that building meaningful environments aids students’ investment and engagement in learning. The study utilizes a questionnaire and classroom observations to explore the relationship between FSR and students’ level of engagement. The results revealed a significant difference between the rapport‐building and nonrapport‐building groups at a personal and academic level. The findings shed light on student attitudes about various instructional practices and techniques that play a critical role in building a safe, proactive, dynamic, and engaging online environment. Further research is required to reduce the issues related to physical distancing, emotional expressions, and technological competence. Technical competency is the primary prerequisite of any specialized activity; consequently, instructors need to assess learners’ knowledge and accessibility within the learning community. Reflective practice is recommended for faculty members who are thus encouraged to continuously reflect on their teaching practice, redirect and modify their performance to meet their learners’ specific needs, and design and maintain a healthy and encouraging relationship with individual students.
Tailored patient therapeutic educational interventions: A patient‐centred communication model
Authors: Ricci Laetitia , Villegente Julie , Loyal Déborah , Ayav Carole , Kivits Joëlle , Rat Anne‐Christine 
Published: November 2021

AbstractBackgroundTailoring therapeutic education consists of adapting the intervention to patients' needs with the expectation that this individualization will improve the results of the intervention. Communication is the basis for any individualization process. To our knowledge, there is no guide or structured advice to help healthcare providers (HCPs) tailor patient education interventions.ObjectivesWe used a data‐driven qualitative analysis to (1) investigate the reasons why HCPs tailor their educational interventions and (2) identify how this tailoring is effectively conducted. The perspective aimed to better understand how to individualize therapeutic patient education and to disentangle the different elements to set up studies to investigate the mechanisms and effects of individualization.DesignIndividual semistructured interviews with 28 HCPs involved in patient education were conducted. The present study complied with the COREQ criteria.ResultsWhy individualization is necessary: participants outlined that the person must be thought of as unique and that therapeutic education should be adapted to the patient's personality and cognitive abilities. The first step in the individualization process was formalized by an initial patient assessment. Several informal practices were identified: if needed, giving an individual time or involving a specific professional; eliciting individual objectives; reinforcing the relationship by avoiding asymmetrical posture; focusing on patients' concerns; leading sessions in pairs; and making the patient the actor of decisions.ConclusionFrom our thematic data analysis, a model for tailoring patient education interventions based on the Haes and Bensing medical communication framework is proposed. The present work paves the way for evaluation, then generation of recommendations and finally implementation of training for individualization in educational interventions.Short InformativeTailoring in therapeutic education consists of an adaptation to patients' needs. Communication is the basis for any individualization process. There is no model of patient‐centred communication in educational interventions. From semistructured interviews with HCPs, we propose a patient‐centred communication model for tailoring patient education intervention.
Culturally safe, high‐quality breast cancer screening for transgender people: A scoping review protocol
Authors: Peters Micah D. J. , Ramsey Imogen , Kennedy Kate , Sharplin Greg , Eckert Marion 
Published: November 2021

AbstractAimTo develop evidence‐based recommendations for provision of culturally safe, high‐quality services for breast cancer screening for transgender people.DesignThe scoping review will follow the JBI methodological guidance for scoping reviews.MethodsA search using MEDLINE (PubMed), Embase (Ovid), Scopus, the Cochrane Library, including the Cochrane Methodology Register, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and the World Health Organization, Australia Government Department of Health and Google Scholar will be undertaken. The review will include people of any age and ethnicity defined in the source of evidence as transgender. The review will include individuals who have used gender‐affirming interventions or not and sources of evidence that report information relevant to the provision of culturally safe, high‐quality breast cancer screening services for transgender people. English language sources of evidence published from database inception with information from any country will be eligible for inclusion. Sources will be screened for inclusion by three independent reviewers. Results will be extracted using a purpose‐built tool and presented in relation to the review questions and objective in the final report using tables, figures and corresponding narrative. Project funding was approved by the Australian Government Department of Health in June 2020.DiscussionThere are a range of factors that impact on the equity of health access and outcomes for people who are not cisgender. Transgender people are at risk of breast cancer but there is relatively little evidence about how their risks may or may not differ substantially from cis‐gendered individuals and little guidance for health providers to ensure inclusive, culturally safe, high‐quality breast cancer screening services for both transgender males, transgender females and gender diverse people who may not identify as male or as female.ImpactIt is important to provide culturally safe, high‐quality services for breast cancer screening for transgender people.
Predicting the prognosis of glioma by pyroptosis‐related signature
Authors: Chao Bo , Jiang Fenjun , Bai Huiru , Meng Peipei , Wang Lu , Wang Fei 
Published: November 2021

AbstractGlioma is the most common malignant primary brain tumour. It is of great significance for the prognosis and personalized treatment of glioma patients to accurate identification of glioma based on biomarkers. Pyroptosis, a kind of programmed cell death, is closely related to tumour progression and tumour immune microenvironment. However, the role of pyroptosis in glioma remained unclear. Herein, we used glioma clinical and expression data from TCGA and CGGA to explore the relationship between pyroptosis and glioma. We first summarized the incidence of copy number variations and somatic mutations of 33 pyroptosis‐related genes and explored prognostic correlation of these genes. Based on pyroptosis‐related genes, three molecular subgroups of glioma related to prognosis were identified. We also found that each subgroup has unique immune and biological behaviours characteristics. Finally, based on 7 pyroptosis‐related genes (CASP3, CASP4, CASP6, CASP8, CASP9, PRKACA and ELANE), we constructed a prognosis model by Lasso and Cox regression, which had a strong predictive power for the overall survival in CGGA test cohort (p < 0.05). In summary, we explored the role of pyroptosis‐related genes in gliomas and the association of these genes with tumour immunity. We found the biomarkers valuable to diagnosis and prognosis, hence, provide reference to the development and treatment of tumorigenesis in glioma.
Freedom from disease in psoriasis: a Delphi consensus definition by patients, nurses and physicians
Authors: van Ee I. , Deprez E. , Egeberg A. , Augustin M. , Conrad C. , Corazza V. , Donati L. , Lambert J. , Lăpădatu R. , Meyer A. , Paul C. , Penzer‐Hick R. , Stephen K. , van der Zon J. , Bewley A. 
Published: November 2021

AbstractBackgroundPhysician‐reported clinical outcome and quality of life (QoL) measures are currently used to assess outcomes and direct treatment of plaque psoriasis. However, people with psoriasis may have different criteria for judging treatment success.ObjectivesTo build a unified consensus on the definition of ‘freedom from disease’ from a European stakeholder group, including people with psoriasis, dermatologists and nurses.MethodsThe modified Delphi consensus methodology was used to define ‘freedom from disease’, with a consensus group consisting of people with psoriasis, nurses and dermatologists. This methodology involved people with psoriasis during the entire process and consisted of a 15‐member Facilitating Consensus Panel to drive the programme content and a larger Voting Consensus Panel to vote on defining ‘freedom from disease’. The Facilitating Panel agreed on disease domains, and aspects of each domain were put forward to the Voting Consensus Panel to establish relative importance. Following two voting rounds, a meeting was held to agree on a final consensus statement.ResultsThe Facilitating Panel consisted of six patient advocacy group representatives, three specialist nurses and six dermatologists. Voting rounds 1 and 2 were completed by 166 and 130 respondents from the Voting Consensus Panel, respectively. The outputs from both rounds of voting were similar, focusing on normality of living, symptom control, and a relationship of mutual respect and trust between the individual with psoriasis and their healthcare professional. The consensus statement emphasizes that ‘freedom from disease’ is multifaceted and includes the following domains ‘management of clinical symptoms’, ‘psychosocial elements’, ‘QoL and well‐being’, ‘treatment’ and ‘healthcare team support’. ‘Freedom from disease’ means all aspects are addressed.ConclusionsFreedom from disease in psoriasis is a multicomponent concept including five main domains. This diverse and multifaceted patient perspective will help us to improve understanding of the outcomes of treatment interventions in people with psoriasis.
Aerobic scope is not maintained at low temperature and is associated with cardiac aerobic capacity in the three‐spined stickleback Gasterosteus aculeatus
Authors: Ressel Kirsten N. , Cominassi Louise , Sarrimanolis Jon , O'Brien Kristin M. 
Published: November 2021

AbstractMetabolic thermal plasticity is central to the survival of fishes in a changing environment. The eurythermal three‐spined stickleback Gasterosteus aculeatus displays thermal plasticity at the cellular level with an increase in the activity of key metabolic enzymes in response to cold acclimation. Nonetheless, it is unknown if these changes are sufficient to completely compensate for the depressive effects of cold temperature on whole organismal metabolic rate (ṀO2). The authors hypothesized that as a cold‐tolerant, eurythermal fish, absolute aerobic scope (AAS), the difference between the maximum metabolic rate (MMR) and standard metabolic rate (SMR), would be maintained in G. aculeatus following acclimation to a range of temperatures that span its habitat temperatures. To test this hypothesis, G. aculeatus were acclimated to 5, 12 and 20°C for 20–32 weeks, and SMR, MMR and aerobic scope (AS) were quantified at each acclimation temperature. The maximal activity of citrate synthase (CS), a marker enzyme of aerobic metabolism, was also quantified in heart ventricles to determine if cardiac aerobic capacity is associated with AS at these temperatures. SMR increased with acclimation temperature and was significantly different among all three temperature groups. MMR was similar between animals at 5 and 12°C and between animals at 12 and 20°C but was 2.6‐fold lower in fish at 5°C compared with those at 20°C, resulting in a lower AAS in fish at 5°C compared with those at 12 and 20°C. Correlated with a higher AAS in animals acclimated to 12 and 20°C was a larger relative ventricular mass and higher CS activity per 100 g body mass compared with animals at 5°C. Together, the results indicate that despite their eurythermal nature, AS is not maintained at low temperature but is associated with cardiac aerobic metabolic capacity.
Development and performance evaluation of foxtail millet (Setaria italica L.) dehuller
Authors: Chikkaballapur Krishnappa Sunil , Saravanan Shanmugasundaram , Natarajan Venkatachalapathy 
Published: November 2021

AbstractFoxtail millet dehuller for double stage dehulling was developed and evaluated. The machine consists of a hopper, two knurled rolls, two rubber rolls, an air blower, and a grader. The machine was evaluated for foxtail millet (Setaria italica L.) at the different grain moisture content (10, 12, 14, and 17% [w.b.]), types of knurled rolls (diamond, angular, and straight knurled) and feed rate (100,200,300 kg/hr) for performance evaluation or efficiency. The maximum dehulling efficiency and cleaning efficiency of 82.24 and 82.47% was observed for 12% moisture content (w.b.), diamond‐type knurled roll and 100 kg/hr feed rate. Similarly, the maximum head grain yield of 97.82% and the minimum broken of 2.18% was observed for 12% moisture content (w.b.), diamond‐type knurled roll and 300 kg/hr feed rate. There was no significant change in the color values with the treatments. The predicted optimum condition for the machine is moisture content 12% (w.b.), diamond‐type knurled roll and feed rate of 100 kg/hr, which gave an optimum dehulling efficiency of 82.24%, head grain yield of 95.84%, broken of 4.16%, and cleaning efficiency of 82.47% with the desirability of 0.825. The economic analysis shows the suitability of the machine for small‐scale millet processors.Practical ApplicationsDehulling of millets is an essential unit operation in millet processing. This study evaluated the performance analysis of the developed dehuller for foxtail millet at different grain moisture content, types of knurled rolls, and feed rate. The process parameters were optimized, which can be used to design the dehuller for millets. The results obtained show the relevance of applying the developed dehuller for foxtail millet applications, providing an alternative processing machine for millet processing.