bluuebunny/crossref_metadata_2025_split huggingface dataset:
SISTEM INFORMASI MANAJEMEN KEUANGAN DI PONDOK PESANTREN ADH-DHUHA
Authors: Reyhannisa Erico Dwi Ramadhana Reyhannisa Erico Dwi , Fatmawati Azizah 
Published: January 2021

Sistem informasi keuangan merupakan bagian penting dari sebuah instansi dalam melakukan manajemen keuangan. Beberapa instansi sudah memiliki sistem informasi keuangan sendiri namun tidak sedikit yang masih menggunakan sistem manual dengan menggunakan software Microsoft excel. Salah satu instansi yang masih menggunakan sistem manual yaitu pondok pesantren adh-dhuha. Penelitian ini bertujuan mengembangkan sistem informasi manajemen keuangan di pondok pesantren adh-dhuha. Sistem ini memiliki fitur pencatatan keuangan, mencari sekaligus mencetak laporan keuangan, dan mengolah permintaan laporan. Metode yang digunakan dalam penelitian ini yaitu waterfall terdiri dari analisis kebutuhan, desain, penulisan kode program, pengujian, penerapan. Sistem ini dibuat menggunakan bahasa pemrograman PHP dan Framework Codeigniter. Pengujian menggunakan System Usability Scale (SUS) dan Blackbox. Hasil pengujian blackbox testing menunjukan 100% bahwa sistem sudah berjalan dengan baik dan setiap tombol sudah berjalan sesuai dengan fungsinya tanpa ada eror. Pada pengujian SUS dihasilkan nilai 74,25 sehingga sistem dinilai bekerja dengan baik dan layak untuk digunakan dalam melakukan manajemen keuangan yang baik.
Modifikasi Senjata Anggar Untuk Meningkatkan Kekuatan Otot Lengan Pada Atlet Anggar Pemula
Authors: Widowati Atri , Decheline Grafitte 
Published: January 2021

Olahraga Anggar merupakan salah satu olahraga yang sedang dikembangkan di Jambi, terkhusus di Universitas Jambi. Karena merupakan olahraga yang baru mulai dikembangkan di Jambi, maka banyak kendala yang dihadapi oleh pelatih, atlet dan pengurus Anggar di Universitas Jambi (UKM). Salah satu kendala yang sangat besar adalah ketersediaan senjata untuk atlet. Dikarenakan hal tersebut, maka peneliti ingin memodifikasi senjata yang dapat digunakan oleh atlet dengan menyesuaikan dengan kebutuhan atlet di Universitas Jambi. Tujuan dari penelitian ini adalah untuk memodifikasi senjata anggar yang dapat digunakan atlet sekaligus melatih kekuatan otot lengan atlet. Penelitian ini menggunakan penelitian Research and Development (RnD) dimana tahapan yang digunakan adalah menggunakan ADDIE yaitu kegiatan meliputi Analisys, Design, Development, Implementation and Evaluating. Tahapan penelitian ini akan melibatkan 10 orang atlet Anggar di Universitas Jambi, 3 orang expert, baik dari pelatih, dan official pengurus Anggar di Provinsi Jambi. Berdasarkan penelitian yang telah dilakukan, mulai dari tahapan desain alat hingga pengumpulan google form efektivitas senjata yang dimodifikasi 70% efektif untuk meningkatkan kekuatan otot lengan pada atlet Anggar di Universitas Jambi.
Increased expression of fatty acid and ABC transporters enhances seed oil production in camelina
Authors: Cai Guangqin , Wang Geliang , Kim Sang-Chul , Li Jianwu , Zhou Yongming , Wang Xuemin 
Published: January 2021

Abstract
Background: Lipid transporters play an essential role in lipid delivery and distribution, but their influence on seed oil production in oilseed crops is not well studied. Results: Here we examined the effect of two lipid transporters, FAX1 (fatty acid export1) and ABCA9 (ATP-binding cassette transporter subfamily A9) on oil production and lipid metabolism in the oilseed plant Camelina sativa. Overexpression (OE) of FAX1 and ABCA9 increased seed weight and size, with FAX1-OEs and ABCA9-OEs increasing seed length and width, respectively, whereas FAX1/ABCA9-OEs increasing both. FAX1-OE and ABCA9-OE displayed additive effects on seed oil content and seed yield. Also, OE of FAX1 and ABCA9 affected membrane lipid composition in developing pods, especially on phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol. The expression of some genes involved in seed oil synthesis, such as DGAT2, PDAT1, and LEC1, was increased in developing seeds of FAX1- and/or ABCA9-OEs. Conclusions: These results indicate that increased expression of FAX1 and ABCA9 can potentially be applied to improving camelina oil production.
Synthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway
Authors: Zhang Yu , Bian Shiquan , Liu Xiaofeng , Fang Ning , Wang Chunkai , Liu Yanhua , Du Yongmei , Timko Michael P. , Zhang Zhongfeng , Zhang Hongbo 
Published: January 2021

Abstract
Background: Cembranoids are one kind of diterpenoids with multiple biological activities. The tobacco cembratriene-ol (CBT-ol) and cembratriene-diol (CBT-diol) have high anti-insect and anti-fungal activities, which is attracting great attentions for their potential usage in sustainable agriculture. Cembranoids were supposed to be formed through the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, yet the involvement of mevalonate (MVA) pathway in their synthesis remains unclear. Exploring the roles of MVA pathway in cembranoid synthesis could contribute not only to the technical approach but also to the molecular mechanism for cembranoid biosynthesis.Results: We constructed vectors to express cembratriene-ol synthase (CBTS1) and its fusion protein (AD-CBTS1) containing an N-terminal GAL4 AD domain as a translation leader in yeast. Eventually, the modified enzyme AD-CBTS1 was successfully expressed, which further resulted in the production of CBT-ol in the yeast strain BY-T20 with enhanced MVA pathway for geranylgeranyl diphosphate (GGPP) production but not in other yeast strains with low GGPP supply. Subsequently, CBT-diol was also synthesized by co-expression of the modified enzyme AD-CBTS1 and BD-CYP450 in the yeast strain BY-T20.Conclusions: We demonstrated that yeast is insensitive to the tobacco anti-fungal compound CBT-ol or CBT-diol and could be applied to their biosynthesis. This study further established a feasibility for cembranoid production via the MVA pathway and provided an alternative bio-approach for cembranoid biosynthesis in microbes.
Development of key quality indicators for appropriate antibiotic use in the Republic of Korea: results of a modified Delphi survey
Authors: Kim Bongyoung , Lee Myung Jin , Park Se Yoon , Moon Song Mi , Song Kyoung-Ho , Kim Tae Hyong , Kim Eu Suk , Kim Hong Bin 
Published: January 2021

Abstract
Background: An effective antibiotic stewardship program relies on the measurement of appropriate antibiotic use, on which there is a lack of consensus. We aimed to develop a set of key quality indicators (QIs) for nationwide point surveillance in the Republic of Korea.Methods: A systematic literature search of PubMed, EMBASE, and Cochrane Library (publications until 20th November 2019) was conducted. Potential key QIs were retrieved from the search and then evaluated by a multidisciplinary expert panel using a RAND-modified Delphi procedure comprising two online surveys and a face-to-face meeting. Results: The 23 potential key QIs identified from 21 studies were submitted to 25 multidisciplinary expert panels, and 17 key QIs were retained, with a high level of agreement (13 QIs for inpatients, 7 for outpatients, and 3 for surgical prophylaxis). After adding up the importance score and applicability, six key QIs [6 QIs (Q 1–6) for inpatients and 3 (Q 1, 2, and 5) for outpatients] were selected. (1) Prescribe empirical antibiotic therapy according to guideline, (2) change empirical antibiotics to pathogen-directed therapy, (3) obtain culture samples from suspected infection sites, (4) obtain two blood cultures, (5) adapt antibiotic dosage to renal function, and (6) document antibiotic plan. In surgical prophylaxis, the QIs to prescribe antibiotics according to the guideline and initiate antibiotic therapy 1 h before incision were selected.Conclusions: We identified key QIs to measure the appropriateness of antibiotic therapy to identify targets for improvement and to evaluate the effects of antibiotic stewardship intervention.
Farmers’ perceptions of navy bean (Phaseolus vulgaris L.) production constraints, preferred traits, farming systems and their implications on bean breeding: A case study from South East Lowveld region of Zimbabwe
Authors: Mutari Bruce , Sibiya Julia , Nchanji Eileen Bongweh , Simango Kennedy , Gasura Edmore 
Published: January 2021

Abstract
Background: Navy bean is an important legume crop in Zimbabwe. Its production is limited by multiple constraints including biotic, abiotic and socio-economic. However, in the major navy bean-production regions of Zimbabwe, there is no recent study documenting biotic stress management strategies, farmers’ perceived production, and marketing constraints, and cultivar trait preferences. Thus, this study aimed at identifying farmers’ production constraints, preferred traits and cultivars of navy bean, and strategies used to mitigate some of these constraints.Methods: A Participatory Rural Appraisal approach involving transect walks, focus group discussions (FGDs), and formal surveys with semi-structured questionnaires was conducted in four villages of the Lowveld region of Zimbabwe. In each of the four villages, two FGDs (one for men and one for women) were conducted. A total of 176 (75 males and 101 females) navy bean growing households were interviewed. Data from household interviews and FGDs was analysed using the Statistical Package for Social Scientists computer package.Results: The most important constraints to navy bean production were drought stress (Females – 86 %, Males – 73 %), heat stress (Females – 58 %, Males – 55 %), power outages (Females – 46 %, Males – 54 %), poor soil fertility (Females – 32 %; Males – 33 %) and susceptibility to pod shattering (Females – 32 %, Males – 43 %). Mitigation strategies included mulching (18 %), ridges (12 %), reduced acreage (11 %), and cultivating to retain more soil moisture (11 %) for drought stress, while irrigating at night (32 %), and adjusting planting dates (29 %) were used to manage heat stress. Farmer-preferred traits included tolerance to drought and heat, early maturing varieties and disease resistance. Marketing constraints included non-payment for produce in hard currency, lack of diversity in terms of off-takers, high inflation, low grain producer price, delayed payment and breach of contract by contractors. Conclusion: There will be increased adoption of improved navy bean cultivars if breeding programs address the aforementioned constraints and consider farmer-preferred traits when developing new cultivars. Breeders should work closely with extension officers to ensure that cultivars released are cultivated with appropriate agronomic packages for increased productivity and high adoption.
An internet-based emotion regulation intervention versus no intervention for nonsuicidal self-injury in adolescents: study protocol for a feasibility trial
Authors: Morthorst Britt Reuter , Rubæk Lotte , Lindschou Jane , Jakobsen Janus Christian , Gluud Christian Gluud Christian , Bjurebjerg Johan , Hellner Clara , Møhl Bo , Pagsberg Anne Katrine 
Published: January 2021

Abstract
Background: Non-suicidal self-injury (NSSI) has gained increased attention in recent years due to increased prevalence, especially among adolescents. Evidence-based interventions for NSSI are sparse. Emotion regulation individual therapy for adolescents (ERITA) is an online intervention that needs investigation. Non-randomised studies suggest ERITA improves emotion regulations skills and reduces NSSI frequency. Before conducting a large pragmatic randomised clinical trial, we aim to investigate the feasibility of ERITA in Denmark. Methods: A randomised, parallel group feasibility trial comparing ERITA as add on to treatment as usual versus treatment as usual in 30 adolescents age 13-17 years with recurrent NSSI referred to outpatient clinics in The Child and Adolescent Mental Health Services in the Capital Region of Denmark. Feasibility outcomes are 1) completion of follow-up, 2) the fraction of eligible participants who consent to inclusion and randomisation, and 3) compliance with the intervention. Clinical outcomes such as self-injury frequency and the ability to regulate emotions will be investigated exploratorily. Discussion: Internet-based interventions are assumed to be appealing to adolescents by being easily accessible and easy to navigate by tech natives. Disclosure of self-injury behaviour may be facilitated by an online intervention. The evidence for self-injury specific treatment needs to be extended but prior to a large clinical trial, the feasibility of methods and procedures must be assessed. Trial registration: ClinicalTrials.Gov Identifier: NCT04243603
Evaluating Mechanisms of Change in an Oral Hygiene Improvement Trial With Older Adults
Authors: Schensul Jean , Reisine Susan , Salvi Apoorva , Ha Toan , Grady James , Li Jianghong 
Published: January 2021

Abstract
Objectives. This paper examines the relationship between theoretically-driven mediators and clinical outcomes of a group randomized trial to improve oral health and hygiene of older adults in subsidized housing were compared. Methods. Six low-income senior residences were paired and randomized into two groups. The first received a face to face counseling intervention (AMI) and the second, a peer-facilitated health campaign (three oral health fairs) both based on Fishbein’s Integrated Model. 331 participants were recruited at baseline and 306 completed the post-assessment one month after intervention. Clinical outcome s were Gingival Index (GI) and Plaque score (PS), collected by calibrated dental hygienists. Surveys obtained data on patient background characteristics, and ten oral health beliefs, attitudes, norms and behaviors. GLMM assessed the effects of time, intervention arm, moderators and mediators and intervention by time interactions. Results. Baseline moderators were similar. Both outcomes improved significantly. GI scores changed from baseline mean of 0.38 (sd=.032) to .26 (sd=.025) and PS scores changed from baseline mean of 71.4 (sd=18%) to 59.1% (sd=21%). Fears, intentionality, norms, worries, flossing and sugar consumption improved significantly in both interventions from baseline to post intervention. Self-efficacy, perceived risk of oral health problems, locus of control and brushing improved significantly only in the counseling intervention. Mechanisms predicting GI improvement were intentionality, locus of control, brushing and flossing in association with the counseling intervention. Mechanisms predicting PS improvement were worries about oral hygiene self-management and fear of oral diseases in association with the AMI intervention. In the trimmed final models, only locus of control (predicting GI) and fears of oral diseases (predicting PS) were significant. Conclusions. GI and PS improved more in response to the counseling intervention than the campaign. The counseling intervention had a greater impact on mechanisms of change than the campaign. Locus of control, a key concept in oral hygiene interventions including the IM was the main contributing mechanism for GI. Fear, an emotional response drove improvement in PS reinforcing the importance of cognitive/emotional mechanisms in oral hygiene interventions. Improvements in mediators across both interventions suggest a closer examination of the campaign intervention impact on outcomes over time. Trial Registration: Clinicaltrials.gov NCT02419144, first posted April 17, 2015
Late time transition in the evolution of the Universe
Authors: AYDINER EKREM , Oz Isil , Dereli Tekin , Sarisaman Mustafa 
Published: January 2021

Abstract
The late time crossover from a power-law to an exponential expansion of the Universe evolution is the major problem in today’s physical cosmology. Unless this critical transition problem is solved, it is not possible to reach a holistic theory of cosmology. In this study, we propose a simple model in the FLRW framework, where dark matter and dark energy interact through a potential. We analytically solve this model and obtain scale factor a(t) from the presented model. Mainly, employing numerical solutions we show that the scale parameter has a hybrid form which includes power and exponential terms. The numerical results clearly show that there is a time crossover tc in the scale factor a(t) curve, which indicates the transition from the power-law to the exponential expansion of the Universe. We fit these unscaled curves and obtain that scale factor behaves as a(t) ∝ t 2/3 below t ≤ tc, and as a(t) ∝ exp(H0t) with H0 = 0.4 and H0 = 0.3 for the relatively weak and strong interactions above t > tc, respectively. It is the first time that we explicitly obtain a hybrid scale factor incorporating the power and exponential terms as a(t) ∝ t 2/3 e H0t . We conclude that the presented model can solve the late time transition problem of the Universe based on dark matter and dark energy interaction. Additionally, we numerically obtain other kinematic parameters depending upon the scale factor. We discuss the limit behaviors of all relevant cosmological parameters. Our results are completely in good agreement with observational data. Finally, we state that this work makes essential steps towards solving a critical outstanding problem of the cosmology, and has a potential to creates a paradigm for future studies in this field.
Ultra-streamlined single cell proteomics by all-in-one chip and data-independent-acquisition mass spectrometry
Authors: Tu Hsiung-Lin , Gebreyesus Sofani , Siyal Asad Ali , Kitata Reta Birhanu , Chen Eric Sheng-Wen , Enkhbayar Bayarmaa , Angata Takashi , Lin Kuo-I , Chen Yu-Ju 
Published: January 2021

Abstract
Single cell proteomics provides the ultimate resolution to reveal cellular phenotypic heterogeneity and functional network underlying biological processes. Here, we present an ultra-streamlined workflow combining an integrated proteomic chip (iProChip) and data-independent-acquisition (DIA) mass spectrometry for sensitive microproteomics analysis down to single cell level. The iProChip offers multiplexed and automated all-in-one station from cell isolation/counting/imaging to complete proteomic processing within a single device. By mapping to project-specific spectra libraries, the iProChip-DIA enables profiling of 1160 protein groups from triplicate analysis of a single mammalian cell. Furthermore, the applicability of iProChip-DIA was demonstrated using both adherent and non-adherent malignant cells, which reveals 5 orders of proteome coverage, highly consistent ~100-fold protein quantification (1-100 cells) and high reproducibility with low missing values (<16%). With the demonstrated all-in-one cell characterization, ultrahigh sensitivity, robustness, and versatility to add other functionalities, the iProChip-DIA is anticipated to offer general utility to realize advanced proteomics applications at single cell level.
Therapeutic Effects of Noninvasive, Individualized, Transcranial Neuromodulation Treatment for Voiding Dysfunction in Multiple Sclerosis Patients: Study Protocol for a Pilot Clinical Trial
Authors: Tran Khue , Shi Zhaoyue , Karmonik Christof , John Blessy , Rajab Hamida , Helekar Santosh A. , Boone Timothy , Khavari Rose 
Published: January 2021

Abstract
Background: Voiding dysfunction (VD) is a common neurogenic lower urinary tract dysfunction (NLUTD) in multiple sclerosis (MS) patients. Currently, the only effective management for VD and urinary retention in MS patients is catheterization, prompting us to look for novel therapeutic options beyond the bladder, such as the brain. Transcranial rotating permanent magnet stimulator (TRPMS) is a noninvasive, portable, multifocal neuromodulator that simultaneously modulates multiple cortical regions, enhancing or attenuating strengths of functional connections between these regions. The objective of this pilot clinical trial is to evaluate the therapeutic effects of TRPMS in modulating brain regions during voiding initiation and mitigating VD in female MS individuals.Methods: Ten adult female MS patients with VD (defined as having %post-void residual/bladder capacity (%PVR/BC) ≥ 40% or Liverpool nomogram percentile < 10%) will be recruited for this study. Concurrent urodynamic and functional MRI evaluation with a bladder filling/emptying task repeated three to four times will be performed at baseline and post-treatment. Predetermined regions of interest and their blood-oxygen-level-dependent (BOLD) activation at voiding initiation will be identified on each patient’s baseline anatomical and functional MRI scan, corresponding to the microstimulators placement on their individualized TRPMS treatment cap to either stimulate or inhibit these regions. Patients will receive ten 40-minute treatment sessions. Non-instrumented uroflow and validated questionnaires will also be collected at baseline and post-treatment to evaluate clinical improvement.Discussion: Despite the crucial role of the central nervous system in urinary control and its sensitivity to MS, there has been no treatment for urinary dysfunction targeting the brain centers that are involved in proper bladder function. This trial, to our knowledge, will be the first of its kind in humans to consider non-invasive and individualized cortical modulation for treating VD in MS patients. Results from this study will provide a better understanding of the brain control of neurogenic bladders and lay the foundation for a potential alternative therapy for VD in MS patients and other NLUTD in a larger neurogenic population in the future.Trial registration: This trial is registered at ClinicalTrials.Gov (NCT03574610, July 2, 2018, https://clinicaltrials.gov/ct2/show/NCT03574610) and Houston Methodist Research Institute IRB (PRO00019329).
WITHDRAWN: Analysis of Management Approach to Newborn Care of Infants Delivered to COVID-19 Positive Mothers at Five Tertiary Care Centers in the UAE over a 7 Month Period
Authors: Kaushal Monika , Tulasi Yamuna , Kaushal Ayush , Rakhecha Aditya , Memon Rafiq , Ramasamy Karvendhan , Khan Shoaib 
Published: January 2021

Abstract
ObjectivesTo assess newborn care practices, clinical characters and risks of mother to child transmission during rooming in and breastfeeding in infants born to mothers with COVID-19.DesignRetrospective observational study.Participants5 Tertiary care centers located in the UAE. Infants born to mothers diagnosed with COVID-19 at the time of delivery, born between April 1st and October 30th 2020.MethodsIn this retrospective observational study, we analyzed the newborn care practices in various tertiary care hospitals and the rate of transmission of SARS-CoV-2 from mother to infant (vertical or horizontal) while rooming in, breastfeeding and post discharge. Results40 infants were born to mothers with COVID-19 at the time of delivery. One infant tested positive for SARS-CoV-2 after birth and had respiratory symptoms and fever. 23 of the well infants were roomed in during their hospital stay and were breastfed. In 8 cases, the mother and baby were separated and isolated from the time of birth till discharge. 95% of the discharged infants were rooming in with mothers, 45% of the infants were exclusively breastfed and 55% were on mixed feeding (breast milk and formula milk) at the follow-up. None of the infants developed significant health issues or symptoms attributable to SARS-CoV-2.ConclusionThe risk of mother to infant transmission of COVID-19 in the perinatal period is very low. Our study reaffirms the AAP guidelines that rooming in and breastfeeding of newborns born to COVID-19 positive mothers is safe without an increased risk of transmission by following mandated safety precautions.