bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains
Authors: Liu Liu D. , Chen Susu , Hou Han , West Steven J. , Faulkner Mayo ,   The International Brain Laboratory, Economo Michael N. , Li Nuo , Svoboda Karel 
Published: October 2021

AbstractRecently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, have hundreds of recording electrodes distributed over linear shanks that span several millimeters. Because of the length of the probes, linear probe recordings in rodents usually cover multiple brain areas. Typical studies collate recordings across several recording sessions and animals. Neurons recorded in different sessions and animals thus have to be aligned to each other and to a standardized brain coordinate system. Here, we evaluate two typical workflows for localization of individual electrodes in standardized coordinates. These workflows rely on imaging brains with fluorescent probe tracks and warping 3D image stacks to standardized brain atlases. One workflow is based on tissue clearing and selective plane illumination microscopy (SPIM), whereas the other workflow is based on serial block-face two-photon (SBF2P) microscopy. In both cases electrophysiological features are then used to anchor particular electrodes along the reconstructed tracks to specific locations in the brain atlas and therefore to specific brain structures. We performed groundtruth experiments, in which motor cortex outputs are labeled with ChR2 and a fluorescence protein. Light-evoked electrical activity and fluorescence can be independently localized. Recordings from brain regions targeted by the motor cortex reveal better than 0.1-mm accuracy for electrode localization, independent of workflow used.
Exemplum és prudentia. Jan Zamoyski [cenzúrázott] Kasszandra-levele Báthory Zsigmondnak 1593-ból
Authors: Petneházi Gábor 
Published: October 2021

Fin août 1593, Jan Zamoyski (1542–1605), grand chancelier de Pologne adresse une lettre au prince de Transylvanie, Sigismond Báthory. Il s’agit d’une lettre dans laquelle l’homme d’Etat polonais tente de dissuader le prince de s’allier aux Habsbourgs et d’entrer en guerre contre les Ottomans. La lettre en question figure dans l’Histoire de Transylvanie composée par Farkas Bethlen (1639–1679), mais dans une forme tronquée ou modifiée : Bethlen – ou l’éditeur du texte, son neveu, Alexis Bethlen – a soit ransformé, soit supprimé les lignes et les paragraphes critiques à l’égard de la maison des Habsbourgs. Dans mon étude, je republie le texte original (fondée sur une copie de 17e siècle) de la lettre et sa traduction Hongroise. Je me propose aussi d’examiner l’argumentation, fondée sur l’usage de l’exemplum et de l’historia, á laquelle Zamoyski a recours dans son texte.
Todoreszku Gyula és az OSZK Cyrillica-gyűjteménye
Authors: Nagy Levente 
Published: October 2021

L’objectif de mon étude est la présentation des imprimés anciens roumains localisés dans la collectionCyrillica de la Bibliothèque Nationale de Budapest. Au moment présent, la collection est composée de 160 imprimés. Le catalogue central electronique rend compte de 29 imprimés supplémentaires qui proviennent certainement du legs Todoreszku. Il s’agit donc de 189 anciens livres roumains. Dans mon étude, j’esquisserai en grandes lignes la fortune des cyrillica de la collection Todoreszku et l’histoire de la formation de la collection des cyrillica. La recherche m’a fourni l’occasion d’identifier 5 imprimés auparavant inconnus et de constater que la collection renferme 4 exemples uniques d’anciens imprimés roumains.
HUBUNGAN ANTARA DUKUNGAN EMOSIONAL DENGAN KEPATUHAN DIET LANSIA PENDERITA HIPERTENSI
Authors: Rahmatika Dita 
Published: October 2021

Hypertension is a condition where a person's blood pressure reaches 140/90 mmHg. Hypertension is the silent disease that causes death in Indonesia. Elderly people mostly suffer from hypertension. This study aims to investigate the correlationof emotional support and dietary compliance of elderly patients with hypertension around the area of Sukomulyo Community Health Center, Manyar subdistrict, Gresik. This study was an observational analytical research, based on the data collection.This research employed a cross sectional method. The samples used simple random sampling with a sample size of 37 respondents who were elderly patients with hypertension. The respondents’ characteristicswere mostly female with the age criteria of 60- 70 years old, and working as housewives. Meanwhile, the characteristics based on education level suggested that more than half of the respondents were high school graduates. Almost all respondents got emotional support with good category (83.8%), and most respondents were quite obedient in doing diet reaching 67.6%. The result of statistical test of the correlation between emotional support andthe adherence of elderly diet of hypertension show a p-value of 0.552.There is no correlation between family emotional support and the compliance of elderly diet in hypertensive patients in the integrated health postof elderly in the working area of Sukomulyo Community Health Center. The elderly’s family is expected to provide more attention to the elderly to be obedient in having the hypretensive diet.
Water Saturation Modeling Challenges in Oil-Down-to Wells: An Example from a Multidarcy North Sea Reservoir
Authors: Larsen A. , Ahmadhadi F. , Øian E. 
Published: October 2021

Summary
The initial water saturation in a reservoir is important for both hydrocarbon volume estimation and distribution of multiphase flow properties such as relative permeability. Often, a practical reservoir engineering approach is to relate relative permeability to flow property regions by binning of the initial water saturation. The rationale behind this approach is that initial water saturation is related to both the pore-throat radius distribution and the wettability of the rock, both of which affect relative permeability. However, pore-throat radius and wettability are usually not explicitly included in geomodel property modeling. Therefore, the saturation height model should not only capture an average hydrocarbon pore volume but also reflect the underlying mechanisms from hydrocarbon migration history and its impact on initial water saturation distribution.
This work introduces and describes a new term, excess water, for more precise classification of saturation height model scenarios in reservoirs in which multiple mechanisms have interacted and caused a complex water saturation distribution. An example of the presence of transition zones related to drained local perched aquifers (excess water) in oil-down-to (ODT) wells is shown using a limited data set from a North Sea reservoir. The physical basis for drainage and imbibition transition zones connected to both regional and perched aquifers is given. The distribution of initial water saturation in reservoirs containing excess water is demonstrated through numerical modeling of oil migration over millions of years.
Highly permeable reservoirs are more likely to have locally trapped water because of lower capillary forces. A static situation occurs in areas where the capillary forces cannot maintain a high enough water saturation for further water drainage. On the other hand, both high- and low-permeability reservoirs may have significant excess water because of ongoing dynamic effects. In both cases, long distances for water to drain laterally to a regional aquifer enhance the possibility for a dynamic excess water situation.
A Graphics Processing Unit–Based, Industrial Grade Compositional Reservoir Simulator
Authors: Esler K. , Gandham R. , Patacchini L. , Garipov T. , Samardzic A. , Panfili P. , Caresani F. , Pizzolato A. , Cominelli A. 
Published: October 2021

SummaryRecently, graphics processing units (GPUs) have been demonstrated to provide a significant performance benefit for black-oil reservoir simulation, as well as flash calculations that serve an important role in compositional simulation. A comprehensive approach to compositional simulation based on GPUs has yet to emerge, and the question remains as to whether the benefits observed in black-oil simulation persist with a more complex fluid description. We present a positive answer to this question through the extension of a commercial GPU-based black-oil simulator to include a compositional description based on standard cubic equations of state (EOSs). We describe the motivations for the selected nonlinear formulation, including the choice of primary variables and iteration scheme, and support for both fully implicit methods (FIMs) and adaptive implicit methods (AIMs). We then present performance results on an example sector model and simplified synthetic case designed to allow a detailed examination of runtime and memory scaling with respect to the number of hydrocarbon components and model size, as well as the number of processors. We finally show results from two complex asset models (synthetic and real) and examine performance scaling with respect to GPU generation, demonstrating that performance correlates strongly with GPU memory bandwidth.NOTE: This paper is also published as part of the 2021 SPE Reservoir Simulation Conference Special Issue.
Estimating Reservoir Properties from 3D Seismic Attributes Using Simultaneous Prestack Inversion: A Case Study of Lufeng Oil Field, South China Sea
Authors: Wu Qilin , Liu Quanwen , Liu Songxia , Wang Shenjian , Yu Junfeng , Ayers Walter B. , Zhu Qi 
Published: October 2021

Summary
Lufeng oil field was discovered in the 1980s in the Pearl River Mouth Basin (PRMB) of the South China Sea and has entered the stage of secondary oil recovery. One major problem that has restricted the subsequent exploration of the oil field is the unclear regional reservoir and caprock distribution, because practitioners have been using post-stack attributes and acoustic impedance inversion to analyze the distribution of sandstone (reservoir) and mudstone (caprock). In current geophysical research on reservoirs and caprocks, prestack inversion has been widely used because of its advantage over post-stack inversion. However, the accuracy of using single P/S-wave velocity ratio (VP/VS) or density (Vden) inverted by prestack to predict lithology is still insufficient.
In this study, we created a new attribute VRDEN, the sum of VP/VS and the weighted Vden, to capture the lithology variation of the reservoir. We integrated 3D seismic data and well log data and applied simultaneous prestack inversion and multiattribute regression analysis to determine reservoir properties, such as sand thickness, effective porosity, and distribution of sandstone and mudstone of the Lufeng oil field. Then, we calculated the new attribute VRDEN from VP/VS and Vden obtained from simultaneous prestack inversion to determine the lithology variation. The multiattribute regression analysis, combining prestack attributes and post-stack attributes, indicates the effective porosity and sand volume in the Enping Formation, which contains the main oil-bearing reservoirs in the Lufeng oil field.
Results show that when the sandstone thickness is greater than 12.5 m, the prediction error of VRDEN is the lowest compared with VP/VS and Vden. In En-2 member of the Lower Enping Formation, medium- to high-porosity (14 to 17%) sandstone (19.5 m thickness) is widely distributed in the west and middle of the study area, with an area of nearly 300 km2. The high-porosity sand zones stretch from the east of the Lower Enping Formation to the west of the Upper Enping Formation, which is the result of westward progradation of the braided delta.
Our workflow used a novel seismic attribute VRDEN in the simultaneous prestack inversion and multiattribute regression process to provide a more predictive spatial distribution of reservoir-nonreservoir features. The improved reservoir understanding will allow more efficient exploitation of the Lufeng oil field, and the improved workflow will facilitate exploration of other oil fields in the world.
Synthesis, Spectroscopic, X-ray Diffraction and Theoretical Studies of some Novel Nickel(II) Chelates of a Heterocyclic Based Tridentate NNO donor Aroylhydrazone: In vitro DNA Binding and Docking studies
Authors: Nair Yamuna , Joy Francis , Kurup M R Prathapachandra , Kaya Savaş , Serdaroğlu Goncagül , ERKAN Sultan 
Published: October 2021

Abstract
Five new nickel(II) complexes have been synthesised with an NNO donor tridentate aroylhydrazone (HFPB) employing the chloride, nitrate, acetate and perchlorate salts, and all the complexes were physiochemically characterized. Elemental analyses suggested a deprotonated iminolate form of the ligand in four of the complexes, however in one case (2), two aroylhydrazone moieties are binding to the metal centre in the neutral and anionic forms. The structure of the bisligated complex 5, characterized using X ray diffraction studies affirmed that the metal has a distorted octahedral N4O2 coordination environment, with each of the two ligands coordinating through the pyridine nitrogen, imino-hydrazone nitrogen and the deprotonated oxygen of the hydrazone moiety. In order to compare and study the elctronic interactions and stabilities of the metal complexes various quantum chemical parameters were calculated. Moreover, Hirshfeld surface analaysis was carried out for complex 5 in order to determine the intermolecular interactions. The biophysical attributes of the ligand and complex 5 have been investigated with CT DNA and experimental outcomes show that the Ni(II) complex exhibited higher binding propensity towards DNA as compared to ligand. Furthermore, in order to specifically understand the type of interactions of the meatal complexes with DNA molecular docking studies were carried out. In addition, the electronic and related reactivity behaviors of the ligand and five Ni(II) complexes were effectuated using B3LYP/6-31++g**/LANL2DZ level. As expected, the obtained results from NBO computations displayed that the resonance interactions (n→π* and π→π*) play a determinant role in evaluating the chemical attributes of the reported compounds.
Inhalation of a fog of hypochlorous acid (HOCl): Biochemical, antimicrobial, and pathological assessment
Authors: Rasmussen Eric , Robins Lori , Stone R Jeremy , Williams Jeffrey 
Published: October 2021

Abstract
Evidence is emerging of the beneficial effects of inhaling microaerosolized hypochlorous acid (HOCl) as an intervention in the prevention and treatment of respiratory virus infections, including SARS CoV-2. However, little information is available about the effects of inhalation of homogenous HOCl solutions in normal human subjects or in experimental animals. In this report we establish through independent laboratories that the SARS-CoV-2 virus is rapidly inactivated by exposure to HOCl. Inhalation of an aerosolized form of the same HOCl solution by rodents, in accordance with a US-EPA acute 4-hour inhalation toxicity protocol, then provided observational, gross pathological, and histopathological evidence that their pulmonary exposure did not result in any difference when compared to control animals. During the pandemic lockdown, subjective impressions of exposure to aerosolized HOCl were submitted as self-reported responses by employees of a machine-tool shop located in Tacoma, Washington, about 35 miles from Seattle. At that location exposure to HOCl was adopted by a subset of employees as a routine for entry into the facilities. Under short-term, controlled conditions those individuals breathed HOCl misted from a reservoir containing 180 ppm free active chlorine (FAC). Their reports were used to arrive at inferences regarding the effects of exposure. Chemical and antimicrobial characterizations of the aerosols used for these exposures were also performed. Results are discussed in relation to (1) published accounts of HOCl preparations and their effects on respiratory viruses, including rhinoviruses and coronaviruses, and (2) the potential for rational intervention in infections arising from aerosolized pathogens, including the pandemic SARS-CoV-2, using inhalation as a method for administration of HOCl.
Impact of COVID-19 pandemic crisis in Italy: comparison of 2020 with non-pharmaceutical measures and 2021 with pervasive vaccination programs
Authors: Coccia Mario 
Published: October 2021

Abstract
How is the impact of Coronavirus disease 2019 (COVID-19) in Italy in the 2020 (without vaccinations and with non-pharmaceutical interventions) versus 2021 (with a vast roll out of COVID-19 vaccination programs) ? Italy is an interesting case study because was one of first European countries to experience in 2020 higher numbers of COVID-19 related infected individuals and deaths and in 2021 has a high share of people vaccinated against COVID-19.This study answers the question with a comparative analysis of the effects of COVID-19 in 2020 and 2021. Data of confirmed cases, hospitalizations, admissions to ICUs and fatality rate for 176 days are analyzed with the Independent Samples t-Test that compares the means of two groups concerning values from April to September 2020 (without vaccinations and with non-pharmaceutical measures) and 2021 (with pharmaceutical interventions based on a vast vaccination program). Results suggest that in 2020 and in 2021 the impact of COVID-19 in society is rather similar, except fatality rate (significant level 1%). These findings also reveal that the COVID-19 is driven by seasonal and environmental factors that reduce the negative effects in summer period, regardless vaccination campaign. This study can support appropriate and target policy responses of crisis management for countries to face current and likely future pandemics of similar vital agents.
Gender Gaps in Total Factor Productivity: The Case of Manufacturing SMEs in Ghana
Authors: Ackah Charles Godfred , Asuming Patrick Opoku , Agyire-Tettey Frank , Asuman Derek 
Published: October 2021

Abstract
This paper provides evidence on the relative productivity differences between female-owned and male-owned firms in a developing country. We rely on data from a survey of small and medium manufacturing firms in the main industrial hubs of Ghana. We apply quantile regression and decomposition techniques to estimate the productivity gap and identify the mechanism behind the gap at the mean and selected percentiles. Our preferred estimation shows that female-owned firms are more productive at the lower tail of productivity distribution, but less productive at the mean and upper tails. Compositional effects explain the productivity gaps at the lower end of the distribution whilst structural effects are the primary sources of gaps at the upper tail of firm productivity. Finally, we do not find evidence of productivity gaps in female-dominated sectors, though these sectors tend to have lower average productivity.
Effects Of Spent Engine Oil On Soil Characteristics And Selected Phytochemicals In Amaranthus Hybridus
Authors: Swapna Arathy Arunan , Vijayammal Rajani , Radha Dhanya Surendran 
Published: October 2021

Abstract
Spent engine oil is hazardous to the environment. Indiscriminate disposal of spent engine oil drain from engines after servicing has been found to affect the environment. An experiment was carried out to determine the effect of spent engine oil pollution on soil characteristics and the ability of Amaranthushybridusto thrive in the soil supplemented with varying concentrations of spent engine oil ranging from 50- 300 mL. Soil pH was slightly increased due to spent engine oil pollution. Nitrogen, phosphorus and potassium were reduced in the polluted soils and the soil organic carbon was increased. Soil samples polluted with spent engine oil showed increased bulk and particle densities and also decreased water holding capacity and porosity. The spent engine oil pollution affected the phytochemicals and resulted in the increased concentration of anti- nutrient tannin and decreased concentrations of nutrients like alkaloids, flavonoids, etc. The results of this study suggest that spent engine oil at any concentration seriously affects the soil properties and phytochemical analysis showed the inhibitory effects of spent engine oil on Amaranthushybridus.
Study of the quality and antibacterial activity of some honeys
Authors: Mezaini abdelkader , benziane abdelhamid Belhadj , Smaili Naima 
Published: October 2021

Abstract
Honey is a sweet substance that bees make from the nectar of flowers or honeydew, having varying chemical composition and properties. The aim of this research is screening the antimicrobial effects of eight different honey samples from Algeria . Samples of honey were collected from different areas of Tizi-Ouzou. Samples of honey have been studied for their physicochemical and pollen parameters and their antimicrobial effect on Escherichia coli, Staphylococcus aureus , Pseudomonas aeruginosa , Staphylococs epidermitidis, Listeria inocua Enteococcus fecalis Bacillus cerius .The analyzes carried out on the 8 samples of honey reveal a water content of 16.80 to 22%, an acidic pH of 3.70 to 4.04, an electrical conductivity of 0.26 to 0.85 × 10-4 S / cm and a hydroxymethylfurfural level between 16 to 38.03 mg / kg. These results show that these samples are of good quality compared to international standards. The pollen analysis allowed the identification of different botanical families. According to our results all the honey samples have effectively high antibacterial activity against studded strains.
Early humans in South America: the first direct radiocarbon dating and morphometric study of the Toca dos Coqueiros’ skull (Serra da Capivara, Brazil)
Authors: Menéndez Lumila Paula , López-Sosa María Clara , Silva Sergio Francisco Serafim Monteiro da , Martin Gabriela , Pessis Anne-Marie , Guidon Niède , Solari Ana 
Published: October 2021

Abstract

The biological variation of the earliest skeletons of South America has been intensely debated for the last two centuries. One of the major research constraints has been the limited number of available samples dating to the early Holocene. We here present the first direct radiocarbon-date for the early Holocene human skeleton from Toca dos Coqueiros (Serra da Capivara, Brazil), also known as “Zuzu” (8,640+30 BP; 9,526-9,681 cal years BP). We performed craniometric analyses using exclusively samples from Brazil, in order to revisit the sex of the skeleton, and to discuss the evolutionary processes involved in the occupation of the continent. The sex of the individual was estimated as a female when compared to late and early Holocene individuals, but as a male when compared only to the early Holocene series. We also found that Zuzu presents the strongest differences with the late Holocene Guajajara individuals, located nearby, and the strongest similarities with the early Holocene series from Lagoa Santa, attesting for solid biological affinities among early Holocene individuals from Brazil, as well as a moderate level of morphological variation among them. This suggests that the early individuals were part of the same heterogeneous lineage, possibly a different one from which late Holocene populations diverged.