bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing the Legume–Rhizobia Symbiotic Efficiency Due to the Synergy between Commercial Strains and Strains Isolated from Relict Symbiotic Systems
Authors: Safronova Vera , Sazanova Anna , Kuznetsova Irina , Belimov Andrey , Guro Polina , Karlov Denis , Yuzikhin Oleg , Chirak Elizaveta , Verkhozina Alla , Afonin Alexey , Andronov Evgeny , Tikhonovich Igor 
Published: July 2021

The phenomenon of rhizobial synergy was investigated to increase the efficiency of nitrogen-fixing symbiosis of alfalfa (Medicago varia Martyn), common vetch (Vicia sativa L.) or red clover (Trifolium pratense L.). These plants were co-inoculated with the respective commercial strains Sinorhizobium meliloti RCAM1750, Rhizobium leguminosarum RCAM0626 or R. leguminosarum RCAM1365 and with the strains Mesorhizobium japonicum Opo-235, M. japonicum Opo-242, Bradyrhizobium sp. Opo-243 or M. kowhaii Ach-343 isolated from the relict legumes Oxytropis popoviana Peschkova and Astragalus chorinensis Bunge. The isolates mentioned above had additional symbiotic genes (fix, nif, nod, noe and nol) as well as the genes promoting plant growth and symbiosis formation (acdRS, genes associated with the biosynthesis of gibberellins and auxins, genes of T3SS, T4SS and T6SS secretion systems) compared to the commercial strains. Nodulation assays showed that in some variants of co-inoculation the symbiotic parameters of plants such as nodule number, plant biomass or acetylene reduction activity were increased. We assume that the study of microbial synergy using rhizobia of relict legumes will make it possible to carry out targeted selection of co-microsymbionts to increase the efficiency of agricultural legume–rhizobia systems.
Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: a nested case-control study of the UK primary care population
Authors: Liao Weiqi , Clift Ashley K , Patone Martina , Coupland Carol , González-Izquierdo Arturo , Pereira Stephen P , Hippisley-Cox Julia 
Published: July 2021

BackgroundPancreatic cancer has the worst survival rate among all cancers. Almost 70% of patients in the UK were diagnosed at Stage IV.AimThis study aimed to investigate the symptoms associated with the diagnoses of pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine neoplasms (PNEN), and comparatively characterise the symptomatology between the two tumour types to inform earlier diagnosis.Design and settingA nested case-control study in primary care was conducted using data from the QResearch® database. Patients aged ≥25 years and diagnosed with PDAC or PNEN during 2000 to 2019 were included as cases. Up to 10 controls from the same general practice were matched with each case by age, sex, and calendar year using incidence density sampling.MethodConditional logistic regression was used to investigate the association between the 42 shortlisted symptoms and the diagnoses of PDAC and (or) PNEN in different timeframes relative to the index date, adjusting for patients’ sociodemographic characteristics, lifestyle, and relevant comorbidities.ResultsA total of 23 640 patients were identified as diagnosed with PDAC and 596 with PNEN. Of the symptoms identified, 23 were significantly associated with PDAC, and nine symptoms with PNEN. The two alarm symptoms for both tumours were jaundice and gastrointestinal bleeding. The two newly identified symptoms for PDAC were thirst and dark urine. The risk of unintentional weight loss may be longer than 2 years before the diagnosis of PNEN.ConclusionPDAC and PNEN have overlapping symptom profiles. The QCancer® (pancreas) risk prediction model could be updated by including the newly identified symptoms and comorbidities, which could help GPs identify high-risk patients for timely investigation in primary care.
Aplicación del Método del Valor de Transacción de Mercancías
Authors: Sánchez Mamani Rubén 
Published: July 2021

El objetivo del artículo fue determinar si los procesos de importación de mercancías a Bolivia cumplen lo exigido por el art. 5 de la Resolución 1684 de la CAN, para la aplicación del Método del Valor de Transacción de Mercancías (Método Principal). La metodología implicó: analizar la jurisprudencia y doctrina aduanera tributaria; aplicar una entrevista a profundidad a un técnico de la Aduna Nacional y encuestas a 20 importadores con procesos de fiscalización abiertos. Como resultado se detectaron deficiencias en la selección del método, que limitan el cumplimiento de la Resolución. Como principales causas se identificó desconocimiento de la norma por parte de los técnicos de la Aduana Nacional que realizan actividades de fiscalización y de los importadores. Se propuso una Guía de Evaluación que identifica y describe los documentos probatorios necesarios para cumplir la normativa. Socializar el manual propuesto será de utilidad tanto para los importadores como para los técnicos aduaneros.
Impaired Immune Response to SARS-CoV-2 Vaccination in Dialysis Patients and in Kidney Transplant Recipients
Authors: Kolb Thilo , Fischer Svenja , Müller Lisa , Lübke Nadine , Hillebrandt Jonas , Andrée Marcel , Schmitz Michael , Schmidt Claudia , Küçükköylü Seher , Koster Lynn , Kittel Margarethe , Weiland Lea , Dreyling Karl W. , Hetzel Gerd , Adams Ortwin , Schaal Heiner , Ivens Katrin , Rump Lars C. , Timm Jörg , Stegbauer Johannes 
Published: July 2021

Key Points

Immune response to the coronavirus disease 2019 vaccination is significantly reduced in patients with kidney failure compared with controls without kidney failure.After two vaccinations, kidney transplant recipients show the lowest levels of IgGs specific to severe acute respiratory syndrome coronavirus 2, with the lowest neutralizing capacity.These data suggest that vaccination strategies need modification in kidney transplant recipients and patients on dialysis.

Background
Patients with kidney failure on dialysis or after renal transplantation have a high risk for severe COVID-19 infection, and vaccination against SARS-CoV-2 is the only expedient prophylaxis. Generally, immune responses are attenuated in patients with kidney failure, however, systematic analyses of immune responses to SARS-CoV-2 vaccination in patients on dialysis and in kidney transplant recipients (KTRs) are still needed.

Methods
In this prospective, multicentric cohort study, antibody responses to COVID-19 mRNA vaccines (BNT162b2 [BioNTech/Pfizer] or mRNA-1273 [Moderna]) were measured in 32 patients on dialysis and in 28 KTRs. SARS-CoV-2–specific antibodies and neutralization capacity were evaluated and compared with controls (n=78) of a similar age range.

Results
After the first vaccination, SARS-CoV-2–specific antibodies were nearly undetectable in patients with kidney failure. After the second vaccination, 93% of the controls and 88% of patients on dialysis but only 37% of KTRs developed SARS-CoV-2–specific IgG above cutoff. Moreover, mean IgG levels were significantly lower in KTRs (54±93 BAU/ml) compared with patients on dialysis (503±481 BAU/ml; P<0.01). Both KTRs and patients on dialysis had significantly lower IgG levels compared with controls (1992±2485 BAU/ml; P<0.001 and P<0.01, respectively). Importantly, compared with controls, neutralizing antibody titers were significantly lower in KTRs and patients on dialysis. After the second vaccination, 76% of KTRs did not show any neutralization capacity against SARS-CoV-2, suggesting impaired seroprotection.

Conclusions
Patients with kidney failure show a significantly weaker antibody response compared with controls. Most strikingly, only one out of four KTRs developed neutralizing antibodies against SARS-CoV-2 after two doses of vaccine. These data suggest that vaccination strategies need modification in KTRs and patients on dialysis.

Clinical Trial registry name and registration number: Vaccination Against COVID-19 in Chronic Kidney Disease, NCT04743947
Prediksi Bencana Alam di Kota Semarang Menggunakan Algoritma Markov Chains
Authors: Hidayati Nurtriana , Pungkasanti Prind Triajeng , Wakhidah Nur 
Published: July 2021

Bencana alam bukan merupakan hal baru di Indonesian khususnya kota semarang. Data tersebut dapat di lihat pada Badan Penanggulangan Bencana Daerah (BPBD). Data bencana alam yang digunakan sebagai data penelitian diambil dari tahun 2013 hingga 2020 dengan jenis bencana alam berupa banjir, banjir rob, puting beliung, tanah longsor, rumah roboh, pohon tumbang dan kebakaran yang semuanya perlu kita waspadai dan ditanggulangi untuk memperkecil kerugian bagi masyarakat. Prediksi merupakan hal yang dipakai setiap kalangan untuk mengetahui seberapa besar hal yang mungkin terjadi dimasa yang akan datang. Markov Chains adalah metode untuk menghasilkan nilai kemungkinan terhadap sesuatu dengan perhitungan probabilitas. Markov chains disini melakukan prediksi dengan nilai matrik terhadap 7 bencana alam yang terjadi di kota Semang dengan hasil prediksi di tahun 2020 adalah banjir 35 %, rob banjir 0%, tanah longsor 22%, puting beliung 3%, rumah roboh 2%, kebakaran 30% dan pohon tumbang 8%. Sedangkan di tahun 2021 prosentase prediksi banjir 22 %, rob banjir 3%, tanah longsor 22%, puting beliung 2%, rumah roboh 8%, kebakaran 33% dan pohon tumbang 9%.
Registro das espécies de tubarões encontradas nas áreas de Unidades do Mosaico Juréia-Itátins e APA-CIP-SP (Área de Proteção Ambiental, Cananéia -Iguape-Peruíbe) pelo Projeto SOS Tubarões-IBIMM / Record of shark species discover in the areas of Mosaic Units Jureia-Itatins and APA-CIP-SP (Environmental Protection Area, Cananeia -Iguape-Peruíbe) by the SOS Tubarões-IBIMM Project
Authors: Lopes Edris Queiroz , De Freitas Seiti Moreira , Pássaros Victor Washington Andrade , De Souza Luna Vitória Mendes , De Melo Luana Félix 
Published: July 2021

Os tubarões são animais vertebrados da classe dos Chondrichthyes, ou seja, ele é um peixe cartilaginoso, e da subclasse Elasmobranchii, habitam os mais diversos ambientes oceânicos, desde a costa a grandes profundidades e diferentes temperaturas. No presente trabalho foi descrito e realizado a biometria de animais nenonatos, juvenis e adultos; sendo estes, 64 espécimes de tubarões capturados por pescadores enocntados em bancas de pescados do Portinho de Pesca de Peruibe e praias da região, entre eles o destaque para alguns tubarões tigre ou tintureira, cação squalus, cação bruxa e 01 cação galhudo de 02 cabeças. O objetivo desse estudo é contribuir com o conhecimento da biologia e ecologia das espécies de tubarões encontrados nas unidades de conservação que fazem parte do Projeto SOS Tubarões do IBIMM (Instituto de Biologia Marinha e Meio Ambiente), afim de contribuir com a literatura disponível e subsidiar novos estudos.
“Detección de semillas de soja genéticamente modificadas, (Glycine max, L. Merril), resistente al glifosato, en muestras de semillas convencionales a través del bioensayo” / “Detection of genetically modified soybean seeds, (Glycine max, L. Merril), resistant to glyphosate, in conventional seed samples through bioassay”
Authors: Almada Luz , Hepp Liza 
Published: July 2021

A nivel mundial los organismos genéticamente modificados (GM) resistente a glifosato corresponde a 41 millones de hectáreas. La presencia de semillas de soja GM en lotes de semillas convencionales se ha convertido en un problema creciente para los comercios internacionales de la soja. Reconociendo la importancia de nuevos mercados y los productos modificados genéticamente, la tecnología tendrá que asegurar la pureza de las semillas, la genética de los productos derivados de la biotecnología a través de pruebas confiables prácticos. En este contexto, los objetivos del experimento fueron comprobar la eficacia de las pruebas de germinación con herbicidas, en diferentes sustratos (Bioensayos) para la detección de las mezclas de cultivos modificados genéticamente en muestras de las semillas convencionales. Se seleccionaran, 2 lotes de semilla convencionales, BRS 282, V1 Vmax, y un lote de semillas genéticamente modificadas V2 MUNASQA. De las semillas genéticamente modificadas se establecieron diferentes niveles, para la mezcla con las semillas convencionales, N1 0, N2 2%, N3 4%, N4 6%. Se establecieron un total de cuatro tratamientos, y los datos obtenidos fueron analizados por análisis de regresión con coeficiente de determinación. Teniendo en cuenta el estado fisiológico de las plántulas según la clasificación en normales, anormales y muertas.Se puede concluir entonces que las semillas genéticamente modificadas con resistencia al glifosato mostraron diferencias en su desenvolvimiento al someterse a los test de germinación con determinada dosis de glifosato. Indicando que de entre los cuatro test utilizados el mejor fue el método de preimbibición.
SECURE SOFTWARE-DEFINED NETWORK MODEL INKVM VIRTUALIZATION ENVIRONMENT
Authors: Сахаров Д.В. , Красов А.В. , Ушаков И.А. , Орлов Г.А. 
Published: July 2021

Рассматривается новая сетевая парадигма SDN (Software Defined Networks), в которой архитектура переходит от традиционной полностью распределенной модели к более централизованной. Данный подход характеризуется также раз делением плоскости данных и плоскости управления. Уровень управления сетью и уровень передачи данных разделяются, а функции управления сетью переносятся с маршрутизаторов и коммутаторов на программные приложения. Научная задача разработка защищенной модели SDN.
A new network paradigm SDN (Software Defined Networks), in which the network architecture moves from a traditional fully distributed model to a more centralizedone, is considered. This approach is also characterized by the separation of the data plane and the control plane. The network management layer and the data transfer layer are separated, and the network management functions are transferred from routers and switches to software applications. The scientific task is the development of a secure SDN model.
LIMITATION OF ITU RECOMMENDATIONS FOR ATTENUATION OF OPTICAL WAVELENGTHS IN RAIN
Authors: Милютин Е.Р. 
Published: July 2021

Показано, что методика прогнозирования, содержащаяся в Рекомендациях МСЭ, справедлива только в части оптического диапазона.
It is shown that the forecasting methodology contained in ITU Recommendations is valid only in the part of the optical range.
A BAND ENHANCEMENT OF PATCH ANTENNAS BY THE DISTRIBUTED EXCITATIONS
Authors: Воскресенский Д.И. , Овчинникова Е.В. , Нгуен Д.То. , Кондратьева С.Г. , Шмачилин П.А. 
Published: July 2021

Разработаны модели печатных излучателей. Показана возможность расширения рабочей полосы излучателя по характеристикам согласования с помощью распределенного возбуждения. Определены характеристики направленности и частотные характеристики печатных излучателей.
Models of patch antennas are developed. The possibility of extending the working band of patch antenna with the help of distributed excitation is shown. Directional characteristics and frequency characteristics of patch antennas are determined.
ADVANTAGES OF AMOOFDM SYSTEM OVER OTHERTECHNOLOGIES: A REVIEW
Authors: Язбек Х. , Беляев В.В. , Ткаченко И.М. 
Published: July 2021

В настоящее время желание клиентов получить более высокую скорость доступа и снизить стоимость услуг за- ставляет операторов постоянно развивать свои сети. Кроме того, операторы вынуждены увеличивать размеры сетей доступа, чтобы обслужить как можно больше домохозяйств, охватить весь город, район крупного города или его окрестности в радиусе до 60 км. Также остаются актуальными проблемы ограниченного количества сервисов сети, недостаточной зоны покрытия и слишком высокой стоимости услуг для среднего абонента. Довольно много сетей все еще используют наземную беспроводную связь для организации каналов внутри или между городскими кварталами, но есть и операторы, которые используют технологию FTTH (оптоволокно до дома). В статье сравниваются производительность, пропускная способность и максимальный размер действующих сетей доступа и перспективных сетей, использующих адаптивно-модулированное оптическое ортогональное частотное мультиплексирование (AMOOFDM). Также показаны преимущества системы AMOOFDM, в которой в качестве модулятора интенсивности применяется полупроводниковый оптический усилитель.
Access networks are under constant development looking for customers satisfaction by enhancing the Internet service speed and the cost of the service. However, a significant percentage of these networks still using the terrestrial radio wave telecommunications to distribute the service inside or between city blocks, while others use the fiber to the home (FTTH). The article compares the performance of the currently operated access networks to the adaptively modulated optical orthogonal frequency multiplexing (AMOOFDM) based access networks, according to the bit-rate, and the distance reach of these networks. The advantages of the AMOOFDM system, in which a semiconductor optical amplifier (SOA) is used as an intensity modulator, are shown.
PENGARUH LATIHAN FISIK TERSTRUKTUR TERHADAP PENURUNAN KADAR KOLESTROL PADA PASIEN HIPERTENSI DI RS GRANDMED LUBUK PAKAM
Authors: Zannah Miftahul , Karo-karo Tati Murni , Yolanda Ida , Ginting Rosita , Sitepu Abdi Lestari 
Published: July 2021

Hypertension and elevated cholesterol are two continuous conditions. Cholesterol level in the body is one of the most important factors to determine a person's risk of suffering from heart artery disease. Therefor it is necessary to provide Structured Physical Exercise in the form of regular exercise, in addition to reducing stress, it can also lose weight, burn more fat in the blood, and strengthen the heart muscle. To be able to do light exercise, you don't need to come to a special training ground, because the best program is one that you enjoy and can take place regularly. Methods: This study used a quantitative experimental method using post-test design with a control group (pretest-posttest with control group) with a sample size of 15 people. Sampling was used with purposive sampling technique using the Isac and Mikael formulas, the study was used in April 2021. Results: From the research results found in the experimental group the p value was 0.000 ≤ 0.05 and in the control group the p value was 0.001 ≤ 0.05. So it can be concluded that the experimental group gives a better effect than the control group on hypertension patients at Grandmed Lubuk Pakam Hospital in 2021. Therefor it is hoped that nurses at Grandmed Lubuk Pakam Hospital can improve services in non-pharmacological fields, especially for hypertension patients who suffering from hypercholesterolemia which can be overcome by giving intervention in the form of structured physical exercise.
PENDAMPINGAN IBU HAMIL DALAM PENANGGULANGAN KEJADIAN KEK DI PUSKESMAS TINGGI RAJA
Authors: Siregar Annisa Febriana , Manurung Jelita , Ginting Wira Maria 
Published: July 2021

Abstrak
Kekurangan Energi Kronik (KEK) merupakan permasalahan yang sampai saat ini masih menjadi permasalahan di Indonesia. Banyak efek negatif yang akan terjadi apabila kondisi ini tidak diselesaikan seperti kesulitan dalam persalinan, pendarahan dan berpeluang kelahiran bayi dengan kondisi BBLR. Pendampingan ibu hamil selama masa kehamilan merupakan salah satu upaya untuk menganggulangi resiko KEK dengan mendorong, memotivasi serta membangkitkan kesadaran akan potensi yang dimiliki dan berupaya untuk mengembangkan potensi itu menjadi tindakan nyata dalam pencegahan KEK. Pendampingan dilakukan di Puskesmas Tinggi Raja dengan pemberian penyuluhan dan pemberian kuisioner yang berisikan pemahaman ibu hamil tentang kehamilan dengan KEK. Hasil survei tersebut yang dilakukan pada 2 Februari 2021 diperoleh hasil dari 32 ibu, 5 diantaranya belum memahami dan 27 ibu sudah mengetahui kehamilan dengan KEK. Uraian data dan fakta yang ada dengan metode pendampingan pada ibu hamil yang mengalami KEK dan keluarga dapat membantu ibu dalam meningkatkan pengetahuan dan meningkatkan status kesehatannya selama kehamilan serta mencegah resiko yang dapat terjadi pada ibu hamil dengan KEK. Kegiatan PKM ini dilakukan agar dapat meningkatkan pengetahuan dan pemahaman ibu hamil mengenai KEK serta mencegah resiko yang terjadi akibat kekurangan energi kronik. Pelaksana kegiatan ini adalah tim Pengabdian Masyarakat Institut Kesehatan Medistra Prodi Gizi yang terdiri dari dosen yang berada di program studi gizi.

Kata Kunci: Pedampingan; Ibu Hamil, Kurang Energi Kronik
PENGARUH PAJAK DAN TUNNELING INCENTIVE TERHADAP INDIKASI MELAKUKAN TRANSFER PRICING (STUDI KASUS PADA PERUSAHAAN LQ-45 YANG TERINDEKS DI BURSA EFEK INDONESIA)
Authors: Maulani Silma Taqiya , Ismatullah Ismet , Rinaldi Rinaldi 
Published: July 2021

ABSTRAKSalah satu indikasi perusahaan melakukan transfer pricing adalah menginginkan laba yang tinggi dengan membayar pajak yang rendah. Struktur kepemilikikan juga mempengaruhi manajemen untuk mengalihkan kekayaan kepada mereka sendiri atau pemegang saham mayoritas. Penelitian ini bertujuan untuk meneliti pengaruh pajak dan tunneling incentive terhadap indikasi melakukan transfer pricing pada perusahaan LQ 45 yang terindeks di Bursa Efek Indonesia. Sampel penelitian yang digunakan dalam penelitian ini adalah perusahaan LQ-45 yang terdaftar secara konsisten selama periode 2015-2019 dengan metode purposive sampling. Hasil dari penelitian ini menunjukkan bahwa pajak tidak berpengaruh signifikan terhadap indikasi transfer pricing, sementara tunneling incentive berpengaruh signifikan terhadap transfer pricing. Hal ini dibuktikan dengan nilai probabilitas 0.05 lebih kecil nilai probabilitas variabel pajak atau 0,05 < 0,13. Sementara nilai probabilitas 0.05 lebih besar dari nilai probabilitas variabel Tunneling incentive atau 0,05 > 0,01. Kata Kunci : Pajak, Tunneling Incentive, Transfer Pricing ABSTRACTOne indication of a company doing transfer pricing is wanting high profits by paying low taxes. The ownership structure also influences management to transfer wealth to themselves or the majority shareholder. This study aims to examine the effect of taxes and tunneling incentives on indications of transfer pricing on LQ 45 companies indexed on the Indonesia Stock Exchange. The research sample used in this study was LQ-45 companies that were consistently registered during the 2015-2019 period with the purposive sampling method. The results of this study indicate that taxes have no significant effect on transfer pricing indications, while tunneling incentives have a significant effect on transfer pricing. This is evidenced by the probability value of 0.05 which is smaller than the probability value of the tax variable or 0.05 < 0.13. While the probability value of 0.05 is greater than the probability value of the Tunneling incentive variable or 0.05 > 0.01. Keywords: Tax, Tunneling Incentive, Transfer Pricing
FARUL3S: a New Framework for Agile Regulated Ultra-Large-Scale Software Systems
Authors: KSIKSI Amira , Lazzez Onsa , Ltifi Hela , Hamdani Tarek M. , Alimi Adel M. 
Published: July 2021

<p>The Ultra-Large Scale Software (ULSS) system is a novel generation of software systems that requires to be managed and developed across multiple organizations. Such a system challenges the existing agile methods and scaled agile methods as they address only the intra-organizational cooperation. In fact, for inter-organizational coordinations, the ULSS systems have to be regulated as a city rather than being engineered as a building. This paper provides the first Framework for Agile Regulated Ultra-Large-Scale Software System (FARUL3S) that intends to regulate the ULSS systems by constraining the design spaces’ exploration. To this end, we introduced the System Design Rules Hierarchy (SDRH) as a hierarchy of dominance relations that covers the system, platform and application levels. The SDRH, which is the main artifact of our framework, ensures a distributed design spaces’ exploration and helps to provide the interoperability between the different component parts of the ULSS system. The NOV-based analysis of two case studies from the Smart City System prove that the ULSS system regulation improves the added value over its engineering. Thus, to conclude, regulating the ULSS systems makes the system more than the sum of its elements. </p>