bluuebunny/crossref_metadata_2025_split huggingface dataset:
From accurate diagnosis to targeted therapy: depression in general medical practice
Authors: Petrova N. N. 
Published: June 2021

Objective: to analyze the diagnostic significance of clinical and phenomenological characteristics of affective disorders in patients with chronic somatic pathology.Patients and methods. The analysis included the results of a clinical evaluation of 131 patients with chronic somatic pathology, including 96 patients suffering from cardiovascular diseases and 35 patients with cerebral small vessel disease. Clinical assessment included Primary care evaluation of mental disorders (PRIME-MD) and Hamilton Depression Rating Scale.Results and discussion. Despite the significant frequency and transparent clinical symptoms, general practitioners diagnosed mental disorders in only 30% of patients with depression. We observed a higher prevalence of somatic rather than psychological complaints during the clinical survey. According to the screening using PRIME-MD, 74% of patients were diagnosed with mood disorders, anxiety, and somatoform disorders. We also noted their significant comorbidity with a predominance of a depression and anxiety combination (p < 0.001). Hypertensive patients had the highest depression prevalence (87%) and severity. Moderate depression was the most frequent diagnosis in the study participants, corresponding to major depressive disorder (61.5%).Conclusion. In general, the symptoms of anhedonia, depression, and anxiety were most pronounced in patients with affective disorders. The high prevalence of somatic symptoms complicates depression evaluation. It is possible to highlight depression and anhedonia as significant symptoms for the detection of depression in patients with somatic disorders.
The Government in SNA-Compliant DSGE Models
Authors: de-Córdoba Gonzalo F. , Molinari Benedetto , Torres José L. 
Published: June 2021

Abstract
The government size in developed economies expanded remarkably after the Second World War. This growth shaped the role of the government as a key player in the economic activity and the aggregate dynamics of a country. However, the way in which the government is represented in DSGE models is often reductive, containing homogeneous public spending and a few distortionary taxes without clear counterparts in fiscal data. This paper shows how dynamic general equilibrium models can incorporate a detailed government sector as defined in the System of National Accounts (SNA). This government features six types of public expenditures (i.e. the government’s intermediate consumption, public wage bill, debt service, public investment, and transfers to households both in-kind and other-than-in-kind), and five distortionary taxes (i.e. consumption tax, capital and labor income taxes, corporate tax and social contributions).
What (If Anything) Can Justify Basic Income Experiments? Balancing Costs and Benefits in Terms of Justice
Authors: Daemen Josette 
Published: June 2021

Abstract
The central thesis of this essay is that basic income experiments are justified if their expected benefits in terms of justice exceed their expected costs in terms of justice. The benefits are a function of basic income’s effect on the level of justice attained in the context in which it is implemented, and the experiment’s impact on future policy-making. The costs comprise the sacrifices made as a result of the experiment’s interventional character, as well as the study’s opportunity costs. In light of the proposed standard of justification for basic income experiments, the factors that play a role in it, and the way these interact with one another, this essay provides some practical recommendations for researchers hoping to conduct such an experiment.
Classification of impedance cardiography dZ/dt complex subtypes using pattern recognition artificial neural networks
Authors: Benouar Sara , Hafid Abdelakram , Kedir-Talha Malika , Seoane Fernando 
Published: June 2021

Abstract
In impedance cardiography (ICG), the detection of dZ/dt signal (ICG) characteristic points, especially the X point, is a crucial step for the calculation of hemodynamic parameters such as stroke volume (SV) and cardiac output (CO). Unfortunately, for beat-to-beat calculations, the accuracy of the detection is affected by the variability of the ICG complex subtypes. Thus, in this work, automated classification of ICG complexes is proposed to support the detection of ICG characteristic points and the extraction of hemodynamic parameters according to several existing subtypes. A novel pattern recognition artificial neural network (PRANN) approach was implemented, and a divide-and-conquer strategy was used to identify the five different waveforms of the ICG complex waveform with output nodes no greater than 3. The PRANN was trained, tested and validated using a dataset from four volunteers from a measurement of eight electrodes. Once the training was satisfactory, the deployed network was validated on two other datasets that were completely different from the training dataset. As an additional performance validation of the PRANN, each dataset included four volunteers for a total of eight volunteers. The results show an average accuracy of 96% in classifying ICG complex subtypes with only a decrease in the accuracy to 83 and 80% on the validation datasets. This work indicates that the PRANN is a promising method for automated classification of ICG subtypes, facilitating the investigation of the extraction of hemodynamic parameters from beat-to-beat dZ/dt complexes.
Tribocorrosion Mechanisms of Martensitic Stainless Steels
Authors: Gassner A. , Waidelich L. , Palkowski H. , Wilde J. , Mozaffari-Jovein H. 
Published: June 2021

AbstractIn the present study, the influence of the electrochemical potential on the tribocorrosion behavior of X20Cr13 in 0.15 molar NaCl-solution was investigated with the aid of a universal-tribometer under potentiostatic control. The resulting material loss was determined through laser confocal microscopy, while the morphology of the wear tracks and the deformation of the material structure near the surface were observed using light and scanning electron microscopy. The results showed a clear dependence of the material loss and the wear mechanisms from the applied potential. Within the cathodic region, a small amount of the material degradation could be attributed to a strong adhesion and resulting strain hardening as a consequence of an electrochemical weakening and mechanical destruction of the passive layer. The maximum of wear during polarization at the free corrosion potential under friction was explained by galvanic coupling between the wear track and the passive surface near the stability threshold between Fe2+-Ion and Fe2O3development. Through increasing Polarization onto the free corrosion potential in the absence of friction and into the passive region, a decrease in material loss could be observed which is presumably attributed to the stable passive layer that inhibits electrochemical degradation and favors the formation of a grain refinement zone that slows down mechanical destruction.
The effect of electroplating current density on microstructure, corrosion, and wear behavior of Ni–P–W–TiO2 coating
Authors: Sadeghi Sajjad , Ebrahimifar Hadi 
Published: June 2021

Abstract
The use of ceramic particles in the matrix of alloy coatings during the electroplating process has received considerable attention. These particles can create properties such as high corrosion resistance, insolubility, high-temperature stability, strong hardness, and self-lubrication capability. Herein, an Ni–P–W–TiO2 coating was deposited on an AISI 304L steel substrate using the electroplating method. Electroplating was performed at current densities of 10, 15, 20, and 25 mA · cm–2, and the effect of current density on microstructure, corrosion behavior, and wear behavior was investigated. The coatings were characterized by means of scanning electron microscopy. To investigate corrosion resistance, potentiodynamic polarization and electrochemical impedance spectroscopy tests were performed in a 3.5% NaCl aqueous solution. A pin-on-disk test was conducted to test the wear resistance of uncoated and coated samples. Sample micro-hardness was also measured by Vickers hardness testing. Examination of the microstructure revealed that the best coating was produced at a current density of 20 mA · cm–2. The results of potentiodynamic polarization and electrochemical impedance spectroscopy tests were consistent with microscopic images. The coating created at the current density of 20 mA · cm–2 had the highest corrosion resistance compared to other coated and non-coated samples. Furthermore, the results of the wear test showed that increasing the current density of the electroplating path up to 20 mA · cm–2 enhances micro-hardness and wear resistance.
Genome analyses and androgen quantification for an infant with 5α-reductase type 2 deficiency
Authors: Akiba Kazuhisa , Aso Keiko , Hasegawa Yukihiro , Fukami Maki 
Published: June 2021

Abstract

Objectives
5α-reductase type 2 deficiency due to biallelic SRD5A2 variants is a common form of 46,XY disorders of sex development.

Case presentation
A Chinese neonate presented with ambiguous genitalia. He carried a homozygous likely_pathogenic SRD5A2 variant (c.650C>A, p.A217E). His apparently nonconsanguineous parents were heterozygotes for the variant. The variant has previously been identified in two Chinese patients. Our patient carried 14.2 Mb loss-of-heterogeneity regions distributed in the genome. The SRD5A2 variant in this family was invariably coupled with two polymorphisms in exon 1 and intron 1. In the patient, blood testosterone (T)/5α-dihydrotestosterone (5αDHT) ratios were elevated before and during mini puberty, and were higher when measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) than measured by conventional immune assays.

Conclusions
This study provides evidence for the founder effect of an SRD5A2 variant. Furthermore, our data indicate that there is a need to establish a new reference value for T/5αDHT ratios using LC-MS/MS.
Auto-destruction of the thyroid gland and coexisting glutamic acid decarboxylase mediated neurological disease in an adolescent: an unusual presentation of autoimmunity
Authors: Badrinath Murthy Deepa , Gutierrez Alvarez Ana , Vargas Wendy , Litao Melissa Kaori Silva , Shah Bina 
Published: June 2021

Abstract

Objectives
Hashimoto’s thyroiditis (HT) is characterized by lymphocytic thyroid infiltration. Gradual thyroid failure can occur due to thyroid cell apoptosis. Rarely neurological autoimmunity due to glutamic acid decarboxylase (GAD) antigen can co exist with HT.

Case presentation
A seven-year-old male presented with tiredness, weight loss, frequent falls, tachycardia, firm thyromegaly, and abnormal gait. Biochemical markers and thyroid ultrasound (TUS) showed autoimmune hyperthyroidism. Methimazole (MMI) was started and continued for 2.2 years. MRI brain was normal and neurological symptoms resolved. At nine years, he became hypothyroid and levothyroxine (LT4) was started. Serial TUS showed progressive thyroid atrophy. At 14.8 years, he developed epilepsy and fourth cranial nerve palsy, and diagnosed with GAD-65 central nervous system disease. At 15.3 years, TUS showed complete atrophy of right lobe with involuting left lobe volume.

Conclusions
This is an unusual form of atrophic thyroiditis (AT) with coexisting neurological autoimmunity. GAD-65 CNS autoimmunity should be considered in children with AT presenting with neurological signs.
Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns
Authors: Manta-Vogli Penelope D. , Schulpis Kleopatra H. , Loukas Yannis L. , Dotsikas Yannis 
Published: June 2021

Abstract

Objectives
Medium-chain (MCA) and long-chain acylcarnitine (LCA) blood concentrations play a significant role in the fatty acid (FA) oxidation process, especially during the first days of life. Identification of their abnormal concentrations, via expanded newborn screening, can lead to the diagnosis of FA oxidation disorders. This study aimed to demonstrate MCA and LCA concentrations in Dried Blood Spots (DBS) of full-term breastfed infants, in relation to their birth weight (BW) perinatally.

Methods
Breastfed full-term infants (n = 12,000, 6,000 males, 6,000 females) with BW 2,000–3,999 g were divided into four equal groups: Group A, 2,000–2,499 g, B 2,500–2,999 g, C 3,000–3,499 g, and D 3,500–3,999 g. Samples were collected as DBS and acylcarnitines were determined via a liquid chromatography tandem mass spectrometry method.

Results
MCA and LCA blood concentrations were determined significantly lower in group A (low birth weight infants) in both sexes. Infants with BW > 3,500 g (group D), were characterized by lower levels of C10, C10:1, C14, C14:1 acylcarnitines and higher levels of C16 and C18:1 acylcarnitines, as compared to the other groups of this study.

Conclusions
Concentration patterns in full-term breastfed newborns in relation to sex and mainly BW found in this study could be very helpful for neonatologists, especially for newborns of group A.
Growth hormone treatment and bone mineral density in pediatric patients with Prader–Willi syndrome
Authors: Oto Yuji , Murakami Nobuyuki , Inoue Takeshi , Matsubara Keiko , Saima Sohei , Ogata Hiroyuki , Ihara Hiroshi , Nagai Toshiro , Matsubara Tomoyo 
Published: June 2021

Abstract

Objectives
Previous reports indicate that growth hormone (GH) treatment for Prader–Willi syndrome (PWS) improves bone mineral density (BMD) only when initiated at a young age and not when initiated in adulthood. However, there are no data on BMD during long-term GH treatment of Japanese children and adolescents with PWS. Thus, this study aimed to investigate BMD changes among patients with PWS, who were undergoing GH treatment from childhood to adolescence.

Methods
Sixty-seven pediatric patients with PWS who had GH treatment initiated during childhood between January 2003 and June 2020 were evaluated. To avoid underestimation, we used total body BMD, which was evaluated using dual-X-ray absorptiometry adjusted for the BMD z-score using patient height, sex, and age.

Results
In both sexes, age was negatively correlated with the BMD-standard deviation score (SDS) (male: r=−0.156 [p=0.042]; female: r=−0.197 [p=0.043]), which started to decrease in childhood.

Conclusions
The BMD-SDS of patients with PWS decreases gradually despite GH treatment. As there are no clear recommendations about monitoring of bone health in patients with PWS, further studies are needed to improve the guidelines for screening of BMD and treatment of patients with PWS.
The clinical variations and diagnostic challenges of deoxyguanosine kinase deficiency: a descriptive case series
Authors: Doğulu Neslihan , Tuna Kırsaçlıoğlu Ceyda , Köse Engin , Ünlüsoy Aksu Aysel , Kuloğlu Zarife , Kansu Aydan , Eminoğlu Fatma Tuba 
Published: June 2021

Abstract

Objectives
Deoxyguanosine kinase (DGUOK) deficiency is one of the leading causes of the mitochondrial DNA-depletion syndromes (MDDS) associated with hepatocerebral involvement. Herein, we present four cases of DGUOK deficiency to emphasize the clinical variability of disease and the challenges in the diagnosis of DGUOK deficiency.

Case presentation
Hepatomegaly, hyperlactatemia, elevated alpha fetoprotein (AFP), alanine, and transaminase levels were detected in all patients, and cholestasis, coagulopathy, and hypotonia were common findings. All patients had a low birth weight, one patient underwent liver transplantation (LT). Clinical and laboratory findings of two patients and one patient suggested neonatal hemochromatosis and type 1 tyrosinemia, respectively. All patients were diagnosed with DGUOK deficiency by performing molecular genetic analysis.

Conclusions
Mitochondrial DNA-depletion syndromes should be kept in mind in cases in which hypotonicity, lactic acidosis, and neonatal cholestasis are observed. DGUOK deficiency may present in different clinics suggesting neonatal hemochromatosis or tyrosinemia type 1.
Pregnancy in incarcerated women: need for national legislation to standardize care
Authors: Nair Smriti , McGreevy James E. , Hutchinson-Colas Juana , Turock Heather , Chervenak Frank , Bachmann Gloria 
Published: June 2021

Abstract

Objectives
This review examined prenatal care provided to incarcerated women to identify areas where improvement is needed, and examined current legislative gaps such that they can be addressed to ensure uniform templates of care be instituted at women’s prisons.

Methods
Data were compiled from 2000-2021 citations in PubMed and Google Scholar using the keywords: prison AND prenatal care AND pregnancy.

Results
Although the right to health care of inmates is protected under the Eight Amendment to the United States Constitution, the literature suggests that prenatal care of incarcerated individuals is variable and would benefit from uniform federal standards. Inconsistency in reporting requirements has created a scarcity of data for this population, making standardization of care difficult. Although incarceration may result in improved access to care that women may not have had in their community, issues of shackling, inadequate prenatal diet, lack of access to comprehensive mental health management, and poor availability of opioid use disorder (OUD) management such as Medication Assisted Therapy (MAT) amd Opioid Treatment Programs (OTP), history of post-traumatic stress disorder (PTSD) are just a few areas that must be focused on in prenatal care. After birth, mother-baby units (MBU) to enhance maternal-fetal bonding also should be a prison standard.

Conclusions
In addition to implementing templates of care specifically directed to this subgroup of women, standardized state and federal legislation are recommended to ensure that uniform standards of prenatal care are enforced and also to encourage the reporting of data regarding pregnancy and neonatal outcomes in correctional facilities.
Migration, Poverty, the Role of State, (International) Law and Development in the Industrialised Countries of Europe
Authors: Ikejiaku Brian-Vincent 
Published: June 2021

Abstract
The current radical strategies by which there is, on one hand, an increasing European assistance to developing poor countries of Africa/Middle East and on the other hand, tightened border-security within Europe as a means to reduce migration from the South; may worsen the state of poverty in Europe, particularly on the immigrants and impact on the workforce in Europe with implication on development. Though, these strategies may sound radically appealing, they are however, unlikely to reduce migration flows to Europe. While there is still a “wide development gap” between the poor countries of Africa/Middle East and industrialised countries of Europe, migration will often increase, at least in the next two-three decades. Radical border security in Europe will expose the migrants to human trafficking in different form and manifestation contrary to Article 3 UN Protocol on Trafficking in Person. The paper examines the role of the State and Law and development, in addressing the issues of poverty and migration within the industrialised countries of Europe. The research argues that there is the likelihood that poverty and human right issues will increase in Europe in the near-future, if the State/EU fails to play their role, by changing their policy direction and repositioning themselves by improving their Law and development stance. The research employs the human rights-based approach, interdisciplinary and critical-analytical perspective within the framework of international Law and development. It employs qualitative empirical evidence from developed countries of Europe and poor developing countries for analysis.
Record of bats and their echolocation calls from southern Dolakha, central Nepal
Authors: Rai Varsha , Thapa Sanjan , Chalise Prahesh , Shah Karan Bahadur 
Published: June 2021

Abstract
With 52 species, bats make up almost a quarter of all the mammal species in Nepal, and yet remains the least understudied group of mammals. Owing to its diverse geography and climate, more species of bats potentially occur in the country, and acoustic surveys could improve the knowledge of their ecology. So, a study was conducted in Sailung and Melung Rural Municipalities of Dolakha district of Nepal, with the objectives of assessing bat species richness and preparing digital records of their echolocation calls. Using mist-netting and roost survey during three periods in 2018 (late March, late May to early June and mid-November), 10 species of bats were recorded: Cynopterus sphinx, Lyroderma lyra, Rhinolophus ferrumequinum, Rhinolophus luctus, Rhinolophus pearsonii, Rhinolophus sinicus, Hipposideros armiger, Myotis formosus, Myotis sp. and Nyctalus noctula. Ten roosts (mostly caves) were located. Echolocation calls of six of these species were documented, including signals of three species described for the first time in Nepal. This study also reports the fifth record of Myotis formosus in Nepal and new locality record of the species after two decades. The echolocation calls documented hereafter may serve as a reference for species identification for non-invasive studies of bats.
lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p
Authors: Zhao Yuxin , Wang Zhaoxia , Gao Meili , Wang Xuehong , Feng Hui , Cui Yuanyuan , Tian Xia 
Published: June 2021

Abstract
Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported as an oncogene in many tumors including retinoblastoma (RB). This research mainly focused on the functions and mechanism of MALAT1 in RB. MALAT1 was upregulated in RB tissues and cells, and it served as a competing endogenous RNA (ceRNA) and inhibited miRNA-655-3p (miR-655-3p) expression, which eventually regulated the expression of miR-655-3p downstream target ATPase Family AAA Domain Containing 2 (ATAD2). The level of ATAD2 significantly increased, while that of miR-655-3p remarkably decreased in RB tissues and cells. MALAT1 depletion inhibited cell proliferation, metastasis, and epithelial–mesenchymal transition (EMT), but promoted apoptosis in vitro and blocked xenograft tumor growth in vivo. MALAT1 exerted its oncogenic functions in RB by regulating miR-655-3p/ATAD2 axis.
Crystal structure of Al-rich fluorophlogopite, K1.0(Mg2.8Al0.2)(Si2.8Al1.2)O10F2
Authors: Aiqing Chen , Lixue Zhang 
Published: June 2021

Abstract
K1.0(Mg2.8Al0.2)(Si2.8Al1.2)O10F2, monoclinic, C2/m (no. 12), a = 5.3040(11) Å, b = 9.2288(18) Å, c = 10.1286(20) Å, β = 100.173(3)°, V = 488.00(17) Å3, Z = 2, R

gt
(F) = 0.0387, wR

ref
(F
2) = 0.1086, T = 298 K.
Endless skies and open seas – how birds and fish navigate
Authors: Spiecker Lisa , Leberecht Bo , Langebrake Corinna , Laurien Malien , Apte Shambhavi Rajendra , Mouritsen Henrik , Gerlach Gabriele , Liedvogel Miriam 
Published: June 2021

Abstract
Every year, billions of animals leave their home range and start seasonal migrations in order to find more favorable resources and to escape harsh environmental conditions. These round trips often span thousands of kilometers. To successfully navigate along their route, animals rely on various external references. While landmarks and celestial cues like stars or the sun are easy to imagine as guidance on these journeys, using the geomagnetic field for orientation is more elusive. The geomagnetic field is an omnipresent cue, which can be sensed and relied upon by many animals, even when visual cues are sparse. How magnetic fields can be perceived seems to vary between birds and fish. While birds seem to use a mechanism based on the quantum mechanical properties of electron spins, fish may have evolved a compass similar in its function to the technical devises developed by humans. How these mechanisms work precisely and how they are integrated are research questions addressed in SFB 1372.