bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteome analysis demonstrates involvement of endoplasmic reticulum stress response in human myocardium with subclinical left ventricular diastolic dysfunction
Authors: Sato Mizuho , Tsumoto Hiroki , Toba Ayumi , Soejima Yurie , Arai Tomio , Harada Kazumasa , Miura Yuri , Sawabe Motoji 
Published: May 2021

AimHeart failure is increasing in Japan, in particular that with preserved ejection fraction (HFpEF) prevalent in older‐aged patients. The purpose of this study was to investigate the pathophysiology during the early stage of left ventricular (LV) diastolic dysfunction by the quantitative proteome analysis of human myocardium.MethodsAmong 331 post‐mortem autopsy patients, we selected 23 patients (aged 79 ± 9.6 years) with echocardiographic data and without major comorbidities, except hypertension. Cryopreserved autopsy tissue of the LV myocardium was subjected to proteome analysis. LV diastolic function was evaluated by echocardiographic data. Thirteen patients were classified into the impaired diastolic function (IDF) group, and 10 the normal cardiac function group. We performed comparative proteome analysis between the IDF and normal groups by isobaric tags for relative and absolute quantitation (iTRAQ) using nano‐liquid chromatography–tandem mass spectrometry.ResultsThe iTRAQ‐based proteome analysis revealed 57 differentially expressed proteins in the IDF group. Molecular network analysis of differentially expressed proteins indicated that endoplasmic reticulum (ER) stress was a potentially important event. Furthermore, the expressions of proteins associated with the ER stress response, such as glucose‐regulated protein 78 kDa, inositol‐requiring kinase 1α and spliced X‐box binding protein 1, were significantly decreased in the IDF group.ConclusionsThis study suggested that reduced ER stress responses were involved during the early stage of LV diastolic dysfunction. Geriatr Gerontol Int ••; ••: ••–•• Geriatr Gerontol Int 2021; 21: 577–583.
Overcoming barriers to new regional industrial path development: The role of a centre for research‐based innovation
Authors: Kyllingstad Nina 
Published: May 2021

AbstractHow regional industries can develop in an economically sustainable way is high on the research agenda. While the literature on regional change has focused primarily on historical case studies, it has said less about the barriers that hinder the desired change. This article contributes to a better understanding of barriers in regional innovation systems that hamper new regional industrial path development. Furthermore, the article analyses how a new knowledge organisation, the Centre for Research‐based Innovation Offshore Mechatronics in the Agder region of Norway, can contribute to overcoming these barriers. The Centre, which is a policy instrument funded by the Research Council of Norway, aims to contribute to path extension and potentially path modernisation. However, since its foundation, oil prices have dropped severely, resulting in new conditions for the Centre and its partners. The article concludes by discussing whether and how the Centre has contributed to overcoming the barriers that hinder developments beyond path extension.
Bat–bat fly interactions in Central Panama: host traits relate to modularity in a highly specialised network
Authors: Hiller Thomas , Vollstädt Maximilian G. R. , Brändel Stefan D. , Page Rachel A. , Tschapka Marco 
Published: May 2021

Abstract
Recently, network approaches have gained increasing popularity in studies of species interactions. These analyses provide important information about structural and functional organisation, as well as on the dynamics of species interactions. Common model systems for network studies include seed dispersal, pollination, and also parasite interactions.
Bat flies (Diptera: Streblidae, Nycteribiidae) are obligate blood‐sucking ectoparasites of bats. Resource partitioning allows multiple fly species to co‐occur on a single host individual, making them an ideal model system for network analyses.
Between 2013 and 2018 in Central Panama, 6528 bats from 53 species were examined for the presence of bat flies. Thereof, we collected a total of 6077 bat flies belonging to 52 species.
The resulting interaction network showed a significantly higher specificity (H2' = 0.97) and modularity (Q = 0.78) than expected by chance, indicating a very high host specificity of the bat flies. To investigate parasite interactions in the context of host size, host abundance and roosting preferences, we pooled parasite identifications on genus level. The majority of our identified modules were associated with bats using persistent roosting structures. Neither host size nor host abundance appeared to affect module structure. Further, module structure appeared not to be host‐phylogeny driven, instead modules were often composed of species known to share roosting structures.
Their high host‐specificity could put bat flies at risk of extinction in changing environments.
Exploring and explaining older consumers' behaviour in the boom of social media
Authors: Bui Hien Thu 
Published: May 2021

AbstractThe growing number of ageing consumers and their increasingly active engagement in social media platforms present a great opportunity for digital marketing to the grey market. However, the potential of this segment has been underrated by both marketers and marketing scholars. The empirical belief of senior consumers' technological illiteracy somewhat discourages industrial and academic approaches to seeking the answer to some critical questions such as what older consumers think about social media‐based advertising, influencers, or peer communications. Thus, this study aims to explore and explain older consumers' social media‐related behaviour through (a) delving into motives behind their frequently used social media site(s), (b) investigating older consumers' purchase behaviour aspects (i.e., determinant(s) to purchase decisions, favoured shopping modes), (c) discovering what senior consumers think about social media‐based advertising, influencers, and peer communications, and (d) evaluating the impact of social media on older consumers' purchase behaviour. Five key themes emerging from the adopted qualitative approach are (1) Facebook predominance, (2) Scepticism, (3) Price sensitivity, (4) Asymmetric social influences, and (5) Favoured physical store shopping. Each finding is demonstrated in a detailed causal explanation. Academic contributions and implications for social media marketers are highlighted and discussed.
IFN‐α and TNF‐α serum levels and their association with disease severity in Egyptian children and adults with alopecia areata
Authors: Omar Shaimaa I. , Hamza Ashraf M. , Eldabah Nermeen , Habiba Doaa A. 
Published: May 2021

AbstractBackgroundAlopecia areata (AA) is an autoimmune skin disease characterized by abnormal levels of several cytokines, such as interferon alpha (IFN‐α) and tumor necrosis factor‐alpha (TNF‐α), which are T‐helper type 1 cytokines that have important roles in the pathogenesis of AA. The aim of our study was to correlate circulating IFN‐α and TNF‐α levels with disease severity, activity, and clinical type in patients with AA and to evaluate the relationship between the two cytokines.MethodsWe investigated serum IFN‐α and TNF‐α levels in 72 patients with AA (35 children and 35 adults) and 75 healthy control individuals (34 children and 41 adults) using the enzyme‐linked immunosorbent assay (ELISA) technique. We evaluated AA severity using the Severity of Alopecia Tool (SALT) and determined the activity based on dermoscopic criteria of disease activity.ResultsSerum IFN‐α and TNF‐α concentrations were significantly higher in the patients than in the controls. There was a significant positive correlation between serum IFN‐α and TNF‐α levels in all patients with alopecia areata, as well as between serum TNF‐α levels and disease severity in all patients and in children.ConclusionsOur results support the association between IFN‐α and TNF‐α levels and AA and suggest that TNF‐α might be related to disease severity.
Chemical profiles of heated perilla meal extracts and their antioxidant activities
Authors: Park JungYong , Seo HeeBin , La JinWook , Yang Seung‐Ok , Lee YoonHee , Lee JaeHwan 
Published: May 2021

SummaryChemical profiles of aqueous or ethanolic extracts of 140, 170 and 200 °C‐heated perilla meal were identified by GC‐MS, and antioxidant properties of the extracts were observed via in vitro assays and in bulk oil or oil‐in‐water (O/W) emulsion. A total of 22 and 27 chemicals were found in aqueous and ethanolic extracts from non‐heated samples, respectively. As the heating temperature increased to 200 °C, the carbohydrate and derivative contents decreased significantly (P < 0.05), whereas rosmarinic acid concentration decreased in both extracts. Ethanolic extracts possessed higher antioxidant activities than aqueous extracts based on the results of radical scavenging and ferric‐reducing antioxidant power assays and the Rancimat assay, but there were no significant differences among samples (P > 0.05). In the case of O/W emulsions, aqueous extracts inhibited lipid oxidation more efficiently than ethanolic extracts at 50 °C. In particular, heat treatment decreased the antioxidant activities of ethanolic extracts and not aqueous extracts in the O/W emulsion system. Aqueous extracts are recommended in moisture‐rich emulsion‐based foods while ethanolic extracts are more suitable in a lipid‐rich environment for enhancing oxidative stability.
Recovery of bioactive compounds from walnut (Juglans regia L.) green husk by supercritical carbon dioxide extraction
Authors: Romano Raffaele , Aiello Alessandra , Meca Giuseppe , De Luca Lucia , Pizzolongo Fabiana , Masi Paolo 
Published: May 2021

SummaryIn this work, the use of supercritical carbon dioxide, a nontoxic solvent, was proposed to extract bioactive compounds from Juglans regia L. green husk and was compared to other traditional techniques based on solvents such as ethanol, methanol and water. Supercritical CO2 was combined with ethanol as an organic modifier at a rate of 20% of the total flow to achieve greater extraction of polar compounds. The extracts were characterised in terms of extraction yields, antioxidant activity, total polyphenol content, phenolic acids, juglone, volatile organic compounds and antifungal activity. The results showed that the extracts obtained with supercritical CO2 were rich in polyphenols (10750 mg GAE/100 g) and juglone (1192 mg/100 g) and exerted high antioxidant activity and antifungal activity compared with the tested fungi. Walnut green husk is not just a food industry waste but also an important economic source of bioactive compounds that could be used for food active packaging.
Consumer perceptions of insect consumption: a review of western research since 2015
Authors: Ardoin Ryan , Prinyawiwatkul Witoon 
Published: May 2021

SummaryEdible insects have been touted as a sustainable food of the future, but for Western consumers, the concept of entomophagy is largely unfamiliar and often disgusting. This review article discusses current trends in perceptual entomophagy research in Australia, Canada, Europe and the USA since 2015, along with an analysis of the guiding theoretical approaches to predicting insect consumption. Instead of trying to convince unwilling consumers, sensory and consumer science should turn to optimising insect‐eating experiences for potential early adopters. Hedonic evaluations of insect‐based products highlight differences in regional palates, but certain emotional responses seem consistent, including a group of newly coined ‘food‐evoked sensation seeking emotions’. Through clear‐cut insect‐inclusive legislation and effective product development, entomophagy‐specific fear and disgust may diminish over time. Researchers, food companies and governments all play critical roles in integrating insects into modern food systems, but consumer behaviour will ultimately determine the success of novel foods like insects.
Situating service work in action: A review and a pragmatist agenda for analysing interactive service work
Authors: Schneider Anna , Subramanian Dilip , Suquet Jean‐Baptiste , Ughetto Pascal 
Published: May 2021

AbstractResearch on interactive service work has paid close attention to how organizations and frontline employees deal with the inherent complexity of the customer–employee–employer triangle. This raises questions about the agency of interactive service workers with respect to the indeterminacy of service interactions. Our meta‐narrative review finds that the theorization of worker agency in service interactions remains underdeveloped in the two dominant research streams of mainstream management and labour process theory studies. Implicitly or explicitly, these streams either subsume agency under managerial prescription or view it through the binary polar of control and resistance. There has been less focus on service workers’ efforts to overcome practical difficulties in everyday service interactions. To address this lacuna, we offer a conceptual framework that draws on a less prominent, third research stream, which we label pragmatist. This stream includes scholarship largely unfamiliar to the international English‐speaking community, published mainly in French and German academic journals. We propose three contributions in this paper. First, we contribute to the interactive service work literature by mapping the theoretical plurality within and beyond the English‐speaking community. Second, we problematize established streams of research by articulating the intellectual axes of the field; this allows us to present a new research area to account for the concrete dynamics of service interaction and to capture frontline employee agency. Third, we propose a pragmatist research framework coupled with a future research agenda more attentive to the embeddedness and materiality of frontline workers’ situated actions. This way, we address the indeterminacy of interactive situations.
Prostate‐specific antigen density during dutasteride treatment for 1 year predicts the presence of prostate cancer in benign prostatic hyperplasia after the first negative biopsy (PREDICT study)
Authors: Inoue Takaaki , Yoshimura Koji , Terada Naoki , Tsukino Hiromasa , Murota Takashi , Kinoshita Hidefumi , Kamoto Toshiyuki , Ogawa Osamu , Matsuda Tadashi 
Published: May 2021

ObjectivesTo prospectively evaluate the detection rate of prostate cancer, and to identify the risk factors of prostate cancer detection after a 1‐year administration of dutasteride and first negative prostate biopsy.MethodsPatients with benign prostatic hyperplasia who presented high prostate‐specific antigen levels after the first negative prostate biopsy were administered 0.5 mg dutasteride daily for 1 year. They underwent a repeat prostate biopsy after 1 year. The primary end‐point was the detection rate of prostate cancer. The secondary end‐point was the ability of prostate‐specific antigen kinetics to predict prostate cancer detection. Prostate‐specific antigen was measured before the initial prostate biopsy and at 6, 9 and 12 months after starting dutasteride. Patients were classified into a prostate cancer and a non‐prostate cancer group.ResultsProstate cancer was detected in 15 of 149 participants (10.1%). The total prostate‐specific antigen change between the prostate cancer and non‐prostate cancer group at 1 year was significantly different (P = 0.002). Although prostate‐specific antigen levels at baseline did not significantly differ between study groups (P = 0.102), prostate‐specific antigen levels at 6, 9 and 12 months were significantly different (P = 0.002, P = 0.001 and P < 0.001, respectively). The mean reduction rate of prostate‐specific antigen density between the prostate cancer and non‐prostate cancer group at 1 year was significantly different (−4.25 ± 76.5% vs −38.0 ± 28.7%, P = 0.001). Using a multivariate analysis, a >10% increase of prostate‐specific antigen density at 1 year post‐dutasteride treatment was the only predictive risk factor for prostate cancer after the first negative prostate biopsy (odds ratio 11.238, 95% confidence interval 3.112–40.577, P < 0.001).ConclusionIn the present study cohort, >10% increase in prostate‐specific antigen density represented the only significant predictive risk factor for prostate cancer diagnosis in patients with elevated prostate‐specific antigen after the first negative prostate biopsy.
COVID‐19 and family violence: Is this a perfect storm?
Authors: Usher Kim , Bradbury Jones Caroline , Bhullar Navjot , Durkin Dr Joanne , Gyamfi Naomi , Fatema Syadani Riyad , Jackson Debra 
Published: May 2021

AbstractDisasters including public health crises like the COVID‐19 pandemic are known to increase instances of family violence against women, children, and other diverse populations. This paper discusses and provides evidence of disaster‐related vulnerability of and violence towards specific groups of people. We argue that the COVID‐19 pandemic presents the ‘perfect storm’ for family violence, where a set of rare circumstances combine, resulting in a significant aggravation of the resulting event. Given the mental health implications of family violence, mental health professionals need to be aware of this issue during the pandemic and ready to assist with the development of strategies to overcome the situation where possible. To provide protection and prevent violence, there is a need to include at‐risk groups in disaster response and community planning. Such a plan could involve gender and disaster working groups at the local community, state, and national levels.
K4CaSi6O15—Solving a 90‐year‐old riddle
Authors: Liu Hang , Hildebrandt Elias , Krammer Hans , Kahlenberg Volker , Krüger Hannes , Schottenberger Herwig 
Published: May 2021

AbstractPolycrystalline K4CaSi6O15 was prepared from (a) solid‐state reactions between stoichiometric mixtures of the corresponding oxides/carbonates and (b) combustion solution synthesis using K‐ and Ca‐nitrates, tetraethyl orthosilicate (TEOS), and glycine (fuel component) as starting reagents. The compound was characterized by powder X‐ray diffraction. Differential thermal analysis indicated that K4CaSi6O15 melts congruently at about 956°C. On cooling down from the liquid state, a distinct glass‐forming tendency was observed. Single crystals suitable for further structural investigations were obtained from sinter experiments just below the melting point. Basic crystallographic data are as follows: monoclinic symmetry, space group Pc, a = 6.9299(2) Å, b = 27.3496(9) Å, c = 12.2187(4) Å, β = 93.744(3)°, V = 2310.86(13) Å3, Z = 3. The crystal structure of K4CaSi6O15 belongs to the group of interrupted framework silicates with exclusively Q3‐units. The tetrahedral network is the first inorganic representative of the so‐called eth‐type. Charge compensation in the structure is achieved by the incorporation of potassium and calcium cations, which are coordinated by five to nine oxygen ligands. Ninety years after its first mention the present contribution proves the existence of K4CaSi6O15 as a stable phase in the ternary system K2O–CaO–SiO2.
Cognitive decline in older adults: What can we learn from optical coherence tomography (OCT)‐based retinal vascular imaging?
Authors: Abraham Alison G. , Guo Xinxing , Arsiwala Lubaina T. , Dong Yanan , Sharrett A. Richey , Huang David , You Qisheng , Liu Liang , Lujan Brandon J. , Tomlinson Alexander , Mosley Thomas , Coresh Josef , Jia Yali , Mihailovic Aleksandra , Ramulu Pradeep Y. 
Published: May 2021

AbstractIntroductionAccumulated vascular damage contributes to the onset and progression of vascular dementia and possibly to Alzheimer's disease. Here we evaluate the feasibility and utility of using retinal imaging of microvascular markers to identify older adults at risk of cognitive disease.MethodsThe “Eye Determinants of Cognition” (EyeDOC) study recruited a biracial, population‐based sample of participants from two sites: Jackson, MS, and Washington Co, MD. Optical coherence tomographic angiography (OCTA) was used to capture vessel density (VD) from a 6 × 6 mm scan of the macula in several vascular layers from 2017 to 2019. The foveal avascular zone (FAZ) area was also estimated. Image quality was assessed by trained graders at a reading center. A neurocognitive battery of 10 tests was administered at three time points from 2011 to 2019 and incident mild cognitive impairement (MCI)/dementia cases were ascertained. Linear mixed‐effects models were used to evaluate associations of retinal vascular markers with cognitive factor score change over time.ResultsNine‐hundred and seventy‐six older adults (mean age of 78.7 (± 4.4) years, 44% black) were imaged. Gradable images were obtained in 55% (535/976), with low signal strength (66%) and motion artifact (22%) being the largest contributors to poor quality. Among the 297 participants with both high‐quality images and no clinically significant retinal pathology, the average decline in global cognitive function factor score was −0.03 standard deviations per year. In adjusted analyses, no associations of VD or FAZ with longitudinal changes in either global cognitive function or with incident MCI/dementia were found.ConclusionsIn this large biracial community sample of older adults representative of the target population for retinal screening of cognitive risk, we found that obtaining high‐quality OCTA scans was infeasible in a nearly half of older adults. Among the select sample of healthier older adults with scans, OCTA markers were not predictive of cognitive impairment.
Food‐related quality of life in adults with inflammatory bowel disease is associated with restrictive eating behaviour, disease activity and surgery: A prospective multicentre observational study
Authors: Day Alice S. , Yao Chu K. , Costello Samuel P. , Andrews Jane M. , Bryant Robert V. 
Published: May 2021

AbstractBackgroundMeasuring food‐related quality of life (FRQoL) quantifies the psychosocial impact of eating and drinking. FRQoL and associated factors are not well explored in people with inflammatory bowel disease (IBD), despite IBD being a chronic disease affecting the digestive tract. The present study aimed to characterise and identify any patient or disease‐related predictors of FRQoL in individuals with IBD.MethodsAdults with a formal diagnosis of IBD were recruited to a prospective multicentre cross‐sectional study between April 2018 and December 2019. Participants completed questionnaires measuring FRQoL (FRQoL‐29), clinical disease activity (Harvey Bradshaw Index and Simple Clinical Colitis Activity Index), restrictive eating behaviour (Nine‐Item Avoidant/Restrictive Food Intake Disorder Screen), mental health (Depression Anxiety Stress Scale‐21) and other patient and disease‐related variables. A multivariable regression was performed to identify factors associated with FRQoL.ResultsOne hundred and eight participants completed the questionnaires (n = 39, Crohn's disease; n = 69, ulcerative colitis). The mean FRQoL was 79 (95% confidence interval = 75–84) (poor, 0; superior, 145). Poorer FRQoL was observed in those with restrictive eating behaviour associated with fear of a negative consequence from eating (p < 0.0001) and reduced appetite (p < 0.030). Greater FRQoL was observed in those with lower disease activity (p < 0.0001) and previous IBD surgery (p = 0.024). FRQoL was not associated either way by IBD phenotype, duration, or gender. The majority of participants obtained their dietary information from the internet (60%) or gastroenterologist (46%).ConclusionsFRQoL in people with IBD is poorer in those with restrictive eating behaviours and clinically active disease. Interestingly, it was greater in those with previous IBD surgery. Further research is required to validate these associations and explore longitudinal effects of poor FRQoL on patient outcomes and potential strategies for prevention or management of impaired FRQoL in IBD.