bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Exercise Therapy on Anxiety and Depression in Patients With Coronary Heart Disease: A Meta-Analysis of a Randomized Controlled Study
Authors: Wang Lina , Sun Yangli , Zhan Jie , Wu Zhiyuan , Zhang Peiming , Wen Xiaopeng , Ge Shuqi , Han Xu , Lu Liming 
Published: October 2021

Objective: The purpose of this review was to evaluate the effect of exercise therapy on anxiety and depression symptoms in patients with coronary heart disease (CHD).Methods: A systematic review of papers published between January 2000 and February 2021 was conducted. MEDLINE, Embase, the Cochrane Library and Web of Science were searched. Meta-analysis was used to compare the results of the included studies. Bias risk assessment was performed using the Cochrane Collaboration bias risk tool. If half or more of the seven items in Randomized controlled trials (RCTs) were low-risk, then the RCT was considered low-risk research; otherwise, it was high-risk. Statistical analyses were performed using RevMan version 5.3 and STATA version 12.0.Results: We performed a meta-analysis of 11 randomized clinical studies including 771 subjects. Eight studies (73%) were of high quality. Compared with the control group, the exercise group showed a significant improvement in anxiety [standard mean difference (SMD) = −0.61; 95% confidence interval (CI): −0.86, −0.35]. The depression level in the exercise group was also significantly reduced (SMD = −0.48; 95% CI: −0.92, −0.04). Aerobic fitness and athletic endurance also improved [mean difference (MD) = 0.77; 95% CI: 0.58, 0.95; and MD = 20.69; 95% CI: 6.91, 34.46; respectively].Conclusions: This meta-analysis suggests that exercise therapy may be effective in alleviating anxiety and depression symptoms in patients with coronary heart disease. Due to methodological weaknesses, rigorous research needs to be designed to further confirm the effectiveness of exercise therapy in improving the mental health of patients with coronary heart disease.Systematic Review Registration:https://inplasy.com/projects/, identifier: INPLASY202160017.
Analysis of Correlation Between White Matter Changes and Functional Responses in Post-stroke Depression
Authors: Zhang Xuefei , Shi Yu , Fan Tao , Wang Kangling , Zhan Hongrui , Wu Wen 
Published: October 2021

Objective: Post-stroke depression (PSD) is one of the most common neuropsychiatric symptoms with high prevalence, however, the mechanism of the brain network in PSD and the relationship between the structural and functional network remain unclear. This research applies graph theory to structural networks and explores the relationship between structural and functional networks.Methods: Forty-five patients with acute ischemic stroke were divided into the PSD group and post-stroke without depression (non-PSD) group respectively and underwent the magnetic resonance imaging scans. Network construction and Module analysis were used to explore the structural connectivity-functional connectivity (SC-FC) coupling of multi-scale brain networks in patients with PSD.Results: Compared with non-PSD, the structural network in PSD was related to the reduction of clustering and the increase of path length, but the degree of modularity was lower.Conclusions: The SC-FC coupling may serve as a biomarker for PSD. The similarity in SC and FC is associated with cognitive dysfunction, retardation, and desperation. Our findings highlighted the distinction in brain structural-functional networks in PSD.Clinical Trial Registration: https://www.clinicaltrials.gov/ct2/show/NCT03256305, NCT03256305.
Clinical Implication of Caloric and Video Head Impulse Tests for Patients With Enlarged Vestibular Aqueduct Presenting With Vertigo
Authors: Li Ming , Leng Yangming , Liu Bo 
Published: October 2021

Background: By examining the clinical features and results of video head impulse test (vHIT) and caloric tests in patients with enlarged vestibular aqueduct (EVA) presenting with vertigo, we aimed to investigate the function of angular vestibulo-ocular reflex (VOR) and its clinical implications.Methods: Nine patients with EVA manifesting with vertigo were enrolled. The medical history, audiological examination, imaging, and the results of the caloric test and the vHIT were analyzed.Results: Of the nine patients with EVA (eight bilateral and one unilateral case), five were pediatric cases. All 17 ears exhibited sensorineural hearing loss (SNHL). Enlarged vestibular aqueduct patients can present with recurrent (seven cases) or single (two cases) vertigo attack, trauma-induced (two cases), or spontaneous (seven cases) vertigo. Diminished caloric responses were observed in 77.8% (7/9) of the patients (four cases unilaterally and three bilaterally), while unilateral abnormal vHIT results in 11.1% (1/9) patients. Abnormal caloric and normal horizontal vHIT responses were found in 66.7% (6/9) of EVA patients.Conclusions: Vestibular manifestations in EVA are diverse. Enlarged vestibular aqueduct patients with vertigo can present with a reduced caloric response and normal horizontal vHIT, and this pattern of angular VOR impairment was also found in other hydropic ear diseases.
Prevalence and Prognostic Value of Malnutrition Among Elderly Cancer Patients Using Three Scoring Systems
Authors: Zhang Qi , Qian Liang , Liu Tong , Ding Jia-Shan , Zhang Xi , Song Meng-Meng , Wang Zi-Wen , Ge Yi-Zhong , Hu Chun-Lei , Li Xiang-Rui , Tang Meng , Wang Kun-Hua , Barazzoni Rocco , Song Chun-Hua , Xu Hong-Xia , Shi Han-Ping ,   Investigation on Nutrition Status and Its Clinical Outcome of Common Cancers (INSCOC) Group
Published: October 2021

Background: Malnutrition is common in patients with cancer and is associated with adverse outcomes, but few data exist in elderly patients. The aim of this study was to report the prevalence of malnutrition using three different scoring systems and to examine the possible clinical relationship and prognostic consequence of malnutrition in elderly patients with cancer.Methods: Nutritional status was assessed by using controlling nutritional status (CONUT), the prognostic nutritional index (PNI), and the nutritional risk index (NRI). Quality-of-life (Qol) was assessed during admission by using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C-30. Performance status (PS) was assessed by using the Eastern Cooperative Oncology Group (ECOG) classification. The relationship between nutritional status and overall survival and Qol were examined.Results: Data were available for 1,494 elderly patients with cancer (63.65% male), the mean age was 70.76 years. According to the CONUT, NRI, and PNI, 55.02, 58.70, and 11.65% patients were diagnosed with malnutrition, respectively. Worse nutritional status was related to older, lower BMI, lower hand grip strength, and more advanced tumor stage. All malnutrition indexes were correlated with each other (CONUT vs. PNI, r = −0.657; CONUT vs. NRI scores, r = −0.672; PNI vs. NRI scores, r = 0.716, all P &lt; 0.001). During a median follow-up of 43.1 months, 692 (46.32%) patients died. For patients malnourished, the incidence rate (events-per-1,000person-years) was as follows: CONUT (254.18), PNI (429.91), and NRI (261.87). Malnutrition was associated with increased risk for all-cause mortality (adjust HR [95%CI] for CONUT: 1.09 [1.05–1.13], P &lt; 0.001; PNI: 0.98[0.97–0.99], P &lt; 0.001; NRI: 0.98 [0.98–0.99], P &lt; 0.001). All malnutrition indexes improved the predictive ability of the TNM classification system for all-cause mortality. Deterioration of nutritional status was associated with deterioration in Qol parameters and immunotherapeutic response (P &lt; 0.001).Conclusions: Malnutrition was prevalent in elderly patients with cancer, regardless of the assessment tools used, and associated with lower Qol and the immunotherapy response.
Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
Authors: Zhang Li , Xu Zhongju , Jiang Tao , Zhang Jialu , Huang Pinxian , Tan Jiaqi , Chen Gan , Yuan Man , Li Zhuo , Liu Haibin , Gao Dengfeng , Xiao Lianbo , Feng Hui , Xu Jiatuo , Xu Hongxi 
Published: October 2021

Equus asinus L [Equidae; Asini Corii Colla] (donkey-hide gelatin, Ejiao), a well-known traditional Chinese medicine, has been widely used to nourish the blood, especially for women. The aim of this study was to assess the efficacy and safety of Ejiao in blood-deficient patients. A total of 210 participants were recruited and randomly allocated into the placebo control group and Ejiao-treated group (6 g/day). The primary outcomes on the efficacy of Ejiao included traditional Chinese medicine symptom scores, blood indicators, and SF-36. The secondary outcomes were changes in fireness and safety evaluation. Results showed that Ejiao treatment for 8 weeks had significantly improved dizziness symptoms. Among the tested 24 blood biochemical parameters, the hematocrit and red blood cell numbers decreased in the placebo control group, but decreased significantly less in the Ejiao treatment group. The white blood cell and neutrophil counts increased in the Ejiao group but were within the normal range. In addition, the quality of life improved as the scores in SF-36 domains were significantly higher in the Ejiao group. At the same time, there was no significant change in the fire–heat symptoms score or other safety parameters. Considering all these, our study showed that Ejiao has a promising effect in women suffering from blood deficiency without obvious adverse effects.
The Airflow Field Characteristics of the Unmanned Agricultural Aerial System on Oilseed Rape (Brassica napus) Canopy for Supplementary Pollination
Authors: Zhang Songchao , Cai Chen , Li Jiqiang , Sun Tao , Liu Xiaoming , Tian Yong , Xue Xinyu 
Published: October 2021

Pollination success is essential for hybrid oilseed rape (OSR, Brassica napus) seed production, but traditional pollination methods are not efficient. The unmanned agricultural aerial system (UAAS) has developed rapidly and has been widely used in China. When flying, the wind field generated by the rotors overcomes the UAAS gravity, and it blows and disturbs the crops below, which helps the pollen spread. In order to investigate the distribution law of the three-dimensional (direction x, y, z) airflow field, experiments involving three levels of flight speed (FS) at 4.0, 5.0, and 6.0 m/s, and three levels of flight height (FH) at 1.5, 2.0, and 2.5 m were conducted in the OSR field by using an electric four-rotor UAAS P20. The effects of FS and FH on airflow velocities (vx, vy, vz) were analyzed. High-speed dynamic camera (HSDC) technology was used to capture the swings of OSR plants under airflow field disturbance. OSR pollen samples were collected during the experiments. The results showed that the airflow field in the direction x was mainly concentrated on the center of the flight path (S3), and the maximum wind velocity of direction x was 8.01 m/s (T1, S3). The direction x airflow field width was distributed almost symmetrically, but the center position shifted easily, due to crosswind. The airflow field in the direction y was distributed on both sides of the center flight path, and the velocity was generally larger, with the maximum at 7.91 m/s (T1, S2). The airflow field in the direction z was distributed irregularly, and the velocity was small. The FH had highly significant impacts on vx (p < 0.01), and the interaction of FS and FH had significant impacts on vx (0.01 < p < 0.05), while the FS had no significant impact on vx (p = 0.70804 > 0.05). The FS, FH, and interaction of FS and FH all had highly significant impacts on vy (p < 0.01). The swings of the OSR plant captured by the HSDC proved that the UAAS airflow field could effectively blow the OSR plant. The swing amplitude changes showed a positive correlation with airflow velocities (vx) in general. Although the observed OSR plant swung forward and backward repeatedly, there was a law of first forward, and then backward, and forward again at the beginning of each swing. The pollen collected on the sampler verified that the UAAS airflow field could help with pollen spread. The research results provide technical support for UAAS application on supplementary pollination for hybrid OSR seed production.
Molecular Docking and Dynamics Simulation Revealed Ivermectin as Potential Drug against Schistosoma-Associated Bladder Cancer Targeting Protein Signaling: Computational Drug Repositioning Approach
Authors: Siddiqui Arif Jamal , Khan Mohammad Faheem , Hamadou Walid Sabri , Goyal Manish , Jahan Sadaf , Jamal Arshad , Ashraf Syed Amir , Sharma Pankaj , Sachidanandan Manojkumar , Badraoui Riadh , Chaubey Kundan Kumar , Snoussi Mejdi , Adnan Mohd 
Published: October 2021

Urogenital schistosomiasis is caused by Schistosoma haematobium (S. haematobium) infection, which has been linked to the development of bladder cancer. In this study, three repurposing drugs, ivermectin, arteether and praziquantel, were screened to find the potent drug-repurposing candidate against the Schistosoma-associated bladder cancer (SABC) in humans by using computational methods. The biology of most glutathione S-transferases (GSTs) proteins and vascular endothelial growth factor (VEGF) is complex and multifaceted, according to recent evidence, and these proteins actively participate in many tumorigenic processes such as cell proliferation, cell survival and drug resistance. The VEGF and GSTs are now widely acknowledged as an important target for antitumor therapy. Thus, in this present study, ivermectin displayed promising inhibition of bladder cancer cells via targeting VEGF and GSTs signaling. Moreover, molecular docking and molecular dynamics (MD) simulation analysis revealed that ivermectin efficiently targeted the binding pockets of VEGF receptor proteins and possessed stable dynamics behavior at binding sites. Therefore, we proposed here that these compounds must be tested experimentally against VEGF and GST signaling in order to control SABC. Our study lies within the idea of discovering repurposing drugs as inhibitors against the different types of human cancers by targeting essential pathways in order to accelerate the drug development cycle.
Development of Advanced High Strength Automotive Steels
Authors: Tisza Miklós 
Published: October 2021

Abstract
In recent decades, the automotive industry has faced ever-increasing demands. Increasing requirements can be observed in terms of both consumer expectations and legal requirements. On the consumer side, there is a demand for cars that are as economical as possible with lower fuel consumption, but providing also greater comfort and safety. These requirements are accompanied, from a legal point of view by more rigorous environmental regulations and requirements concerning the reduction of harmful emissions. Meeting these often-contradictory requirements is a growing challenge for car manufacturers and raw material suppliers, as well. Meeting the requirements in the most versatile way has resulted in tremendous progress over the last 40–50 years, both in the automotive industry and in the production and development of raw materials. The first part of this series of papers summarizes the main requirements in the automotive industry, as the main driving forces for material developments. Furthermore, the main types and properties of traditional high-strength steels, as well as the so-called first-generation Advanced High-Strength Steels will be introduced. In the second part, the main types and manufacturing processes of second generation advanced high-strength steels will be analyzed and some of the current steel developments will be presented through the results of the three generations of Advanced High-Strength Steels.
Design and Manufacture of a Microfluidic Cell To Be Used With a Spectroscopic Ellipsometer
Authors: Bíró Tamás , Renkó József Bálint 
Published: October 2021

Abstract
In material testing and manufacturing processes, creating thin layers is a widely used method for structure development or for surface treatment purposes. Despite its widespread use, the physical background of the layer development process is currently under-researched. Its examination requires the development of procedures and tools that, in combination with the existing tools, can help to understand these processes. The development of microfluidic cells is a way to solve this problem. In this paper, a newly developed microfluidic cell is presented, which also offers a solution to several problems encountered when using previous designs.
General practice registrars’ clinical uncertainty, and in-consultation information- and assistance-seeking
Authors: Magin Parker , Cooke Georga , Tapley Amanda , Wearne Susan , Holliday Elizabeth , Morgan Simon , Ball Jean , Spike Neil , Van Driel Mieke 
Published: October 2021

Purpose: To explore the association of Australian general practitioner (GP) registrars’ responses to uncertainty with their in-consultation information-, advice- and assistance-seeking.Design/methodology/approach: A cross-sectional analysis of data from the Registrar Clinical Encounters in Training (ReCEnT) cohort study in four Australian states. In ReCEnT, GP registrars record details of 60 consecutive consultations, six-monthly, three times during training.Outcome factors in logistic regression models included whether the registrar sought in-consultation information or assistance from (i) their supervisor or (ii) an electronic or paper-based source. Independent variables were the four independent subscales of the Physicians’ Reaction to Uncertainty (PRU) instrument, as well as registrar, practice and consultation variables.Findings: 589 registrars contributed details of 70,412 consultations.On multivariable analysis, scores on the two ‘affective’ PRU subscales ‘anxiety regarding diagnosis/management’ (OR 1.03; 95% confidence intervals [CIs] [1.01, 1.05], p = 0.003) and ‘concern about a bad outcome’ (OR 1.03; 95% CIs [1.01, 1.06], p = 0.008) were significantly associated with seeking supervisor assistance. There was no association with ‘behavioural’ subscales ‘reluctance to disclose uncertainty to patients’ and ‘reluctance to disclose mistakes to physicians’.None of the PRU subscales were significantly associated with information-seeking from electronic or hard copy sources.Research implications: Further research is required to explore the role of uncertainty within registrar–supervisor interactions and to define the role of supervisors in registrars’ functional adaptation to clinical uncertainty (including how best to support and train supervisors in this role).Practical implications: GP registrars’ ‘affective’ responses to clinical uncertainty are associated with assistance-seeking from clinical supervisors. While in-consultation assistance-seeking may promote registrars’ tolerance of uncertainty, it may also contribute to supervisor workload.Originality/value: This is the first study to examine trainees’ levels of uncertainty and their seeking of information and assistance.Limitations: We have not investigated whether registrars’ seeking assistance resolved or attenuated, for the index problem, their anxiety or concern.
Development of the cultivar xaraés under different concentrations of teak sawdust
Authors: Domiciano Carlos Alberto Ramos , Medeiros Reginaldo Antonio , Teixeira Carlos Adriano , Serafim Milson Evaldo , Sousa Juberto Babilônia de , Tsukamoto Filho Antonio de Arruda , Verly Otávio Miranda , Procópio Natália Cardoso , Leite Helio Garcia 
Published: October 2021

Tectona grandis L.f. (Teak) is a highly cultivated forest species in Brazil. When industrially processed, it generates a large amount of sawdust, a waste that has limited reuse and accumulates in the industrial yards. The aim of this study was to evaluate the effect of fresh teakwood sawdust on the development of Urochloa brizantha (Hochst. ex A.Rich.) R.D.Webster cv. Xaraés in a nursery. The treatments consisted of concentrations of 0, 5, 10, 20, 33 and 50% of sawdust, arranged in four randomized blocks in split-plots. At 45, 75 and 120 days, plant heigh (h), average tillers diameter (d), number of live (nll) and dead leaves per plant, fresh and dry mass of shoots and roots, and Dickson's quality index (dqi) were measured. There was a decrease in h growth, d, nll, fresh and dry mass of shoots and roots and in the dqi of the cv. Xaraés as it increased to concentration of wood sawdust in the substrate. This negative effect can be attributed to the high C/N ratio of sawdust (196/1), which influences the decomposition of organic matter. In addition, the possible Teak allelopathic effects, which are the subject of other studies, should be considered. Unlike the other variables, number of live leaves was not influenced by the treatment with 5% sawdust. Teakwood sawdust has negative effects on the U. brizantha cv. Xaraés development.
Una mirada al trabajo femenino del cultivo de la quinua, en la Región Andina
Authors: Vizcaíno Guerra Maria Jose , Gómez Donoso Ana M. , Buitrón Cañadas Viviana M. 
Published: October 2021

Entre las tareas más complejas que tiene la humanidad para alcanzar los Objetivos de Desarrollo Sostenible de las Naciones Unidas al 2030, están erradicar el hambre, la pobreza y la inequidad de género en el ámbito laboral, (Organización de las Naciones Unidas, 2019). América Latina, a pesar de ser una de las regiones más afectadas por estos aspectos, posee paisajes excepcionales, y una gran biodiversidad y pluriculturalidad. (Comisión Económica para América Latina y el Caribe, 2018). Sin embargo los territorios andinos de Perú, Bolivia, Ecuador y Argentina constituyen el espacio geográfico con extraordinaria capacidad productiva de alimentos nativos (Balbin Ordaya, 2014, p. 33), que debido a su alta calidad nutricional y bondades terapéuticas, se los denomina nutraceúticos. (Balbin Ordaya, 2014, p. 28).
Dentro de todos los cultivos de la región Andina, la quinua Chenopodium quinoa[1], es uno de estos alimentos nativos, denominado grano de oro, por todas las diversas propiedades nutritivas que posee. (Organización de las Naciones Unidas para la Alimentación y la Agricultura, 2012). Si a ello le sumamos la revalorización del territorio rural y la presencia de proyectos e iniciativas comunitarias que promueven el empoderamiento de las mujeres como principales líderes del cultivo y su procesamiento, la quinua constituye una opción saludable, económicamente viable y una de las oportunidades que tienen los pueblos andinos para generar ganancias, reducir la pobreza, erradicar el hambre y contribuir a promover la equidad de género en el trabajo rural, subestimado en la región.

[1] Nombre científico de la Quinua.
Projeto “Hans Broos: da formação técnica ao conjunto da obra”
Authors: Bielschowsky Bernardo Brasil , Correa Ana Paula Pupo , Santos Sara Clarice dos , Moreno Matheus Watanabe 
Published: October 2021

O projeto propôs a articulação da pesquisa e extensão ao ensino, utilizando as obras do arquiteto Hans Broos em Santa Catarina que constam no processo de tombamento em instrução no IPHAN, que foi a instituição demandante externa. A própria comunidade denunciou algumas demolições, que serviram como justificativa para a realização da atividade de extensão. Foi possível inserir a discussão sobre a valorização patrimonial no ensino, com uma equipe multidisciplinar de bolsistas como protagonistas dessas atividades, attavés das atividades de ensino e da apresentação dos resultados do projeto para o público interno e externo ao IFSC, como as instituições de patrimônio (IPHAN, FCC, CAU) e demais universidades que pesquisam no campo acadêmico (UFSC, FURB, UNIDAVI, UNISOCIESC). DOI: https://doi.org/10.35700/ca.2019.ano6n11.p25-36.2665