bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localization of subcentimeter pulmonary nodules using an indocyanine green near-infrared imaging system during uniportal video-assisted thoracoscopic surgery
Authors: Wu Zhuo , Zhang Lei , Zhao Xi-tong , Zhou Di , Yang Xue-ying 
Published: August 2021

Abstract
Background
To investigate the feasibility of indocyanine green (ICG) use in localizing subcentimeter pulmonary nodules during uniportal video-assisted thoracoscopic surgery.

Methods
This study was a retrospective analysis of 32 patients who underwent surgery due to pulmonary nodules using ICG localization from September 2019 to March 2020 in the Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University. Laser positioning and large-aperture spiral CT simulation were performed preoperatively. ICG was injected into the lung (2.5 mg/ml). The clinical characteristics and postoperative indicators were recorded.

Results
A total of 33 subcentimeter pulmonary nodules were successfully localized in 32 patients. Twenty-three patients underwent lobectomy, with an average surgical time of 45.3 min and an average tube retention time of 2 days. Non-small cell lung cancer was confirmed intraoperatively in 9 patients, among whom the longest surgical time was 120 min, and the shortest hospital stay was 7 days. No patient was converted to thoracotomy or developed serious complications.

Conclusions
ICG imaging is a safe and effective technique for localization of pulmonary nodules. Due to the widespread application of near-infrared devices, fluorescent localization and imaging technology will be more widely used in thoracic surgery.
Patient outcomes after electrical injury – a retrospective study
Authors: Ahmed Jamal , Stenkula Charlotte , Omar Sherwan , Ghanima Josef , Bremtun Fredrik Førsund , Bergan Jonas , Raouf Nezar , Ghanima Waleed 
Published: August 2021

Abstract
Introduction
People exposed to electrical injuries are often admitted to hospital for observation. Current evidence suggests that patients who have a normal ECG on admission after a low-voltage injury, with no loss of consciousness or initial cardiac arrest may be discharged home after a short observation time. Currently, there are no established standards for the duration of monitoring after electric shock, but 24 h of observation is the most commonly adopted approach. We carried out a retrospective study of patients admitted after electrical injuries to determine the in-hospital outcomes and 30-day mortality in these patients.

Methods
We performed a chart review of all patients with electrical injuries admitted to Østfold Hospital, Norway between the years 2001 and 2019, to determine in-hospital and 30-day mortality and the frequency of various cardiac and non-cardiac complications.

Results
Mean age of 465 included patients (88% males) was 31 years. Of all injuries, 329 (71%) were work-related, 17 (3.7%) involved loss of consciousness. Furthermore, 29/437 (6.6%) were high voltage (> 1000 V), and 243/401 (60.6%) were transthoracic injuries.
369 (79.4%) were discharged same day. None of the admitted patients died in hospital nor did any die within 30 days of admission, yielding a 30-day mortality of 0% (95% CI 0–0.8). At admission troponin was elevated in three (0.6%) patients, creatinine kinase (CK) in 30 (6.5%) and creatinine in six (1.3%). Electrocardiogram (ECG) abnormalities were described in 85 (18%) patients. No serious arrhythmias were detected.
When comparing high- vs low-voltage or transthoracic vs other injuries, there were no significant differences between most of the outcomes, except for more ECG abnormalities in the transthoracic group, whereas more patients had elevated CK, and fewer discharged the same day in high-voltage injuries.

Conclusion
No in-hospital nor 30-day mortality or serious arrhythmias were encountered in those who were assessed, regardless of the type of injury. Troponin and creatinine were rarely elevated. It seems that conscious patients admitted with a normal ECG following a low-voltage injury may safely be discharged home after a quick clinical assessment including ECG.
Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons
Authors: Miller Daniel S. , Wright Kevin M. 
Published: August 2021

Abstract
Background
The development of functional neural circuits requires the precise formation of synaptic connections between diverse neuronal populations. The molecular pathways that allow GABAergic interneuron subtypes in the mammalian brain to initially recognize their postsynaptic partners remain largely unknown. The transmembrane glycoprotein Dystroglycan is localized to inhibitory synapses in pyramidal neurons, where it is required for the proper function of CCK+ interneurons. However, the precise temporal requirement for Dystroglycan during inhibitory synapse development has not been examined.

Methods
In this study, we use NEXCre or Camk2aCreERT2 to conditionally delete Dystroglycan from newly-born or adult pyramidal neurons, respectively. We then analyze forebrain development from postnatal day 3 through adulthood, with a particular focus on CCK+ interneurons.

Results
In the absence of postsynaptic Dystroglycan in developing pyramidal neurons, presynaptic CCK+ interneurons fail to elaborate their axons and largely disappear from the cortex, hippocampus, amygdala, and olfactory bulb during the first two postnatal weeks. Other interneuron subtypes are unaffected, indicating that CCK+ interneurons are unique in their requirement for postsynaptic Dystroglycan. Dystroglycan does not appear to be required in adult pyramidal neurons to maintain CCK+ interneurons. Bax deletion did not rescue CCK+ interneurons in Dystroglycan mutants during development, suggesting that they are not eliminated by canonical apoptosis. Rather, we observed increased innervation of the striatum, suggesting that the few remaining CCK+ interneurons re-directed their axons to neighboring areas where Dystroglycan expression remained intact.

Conclusion
Together these findings show that Dystroglycan functions as part of a synaptic partner recognition complex that is required early for CCK+ interneuron development in the forebrain.
New results and applications on the existence results for nonlinear coupled systems
Authors: Talib Imran , Abdeljawad Thabet , Alqudah Manar A. , Tunc Cemil , Ameen Rabia 
Published: August 2021

AbstractIn this manuscript, we study a certain classical second-order fully nonlinear coupled system with generalized nonlinear coupled boundary conditions satisfying the monotone assumptions. Our new results unify the existence criteria of certain linear and nonlinear boundary value problems (BVPs) that have been previously studied on a case-by-case basis; for example, Dirichlet and Neumann are special cases. The common feature is that the solution of each BVPs lies in a sector defined by well-ordered coupled lower and upper solutions. The tools we use are the coupled lower and upper solutions approach along with some results of fixed point theory. By means of the coupled lower and upper solutions approach, the considered BVPs are logically modified to new problems, known as modified BVPs. The solution of the modified BVPs leads to the solution of the original BVPs. In our case, we only require the Nagumo condition to get a priori bound on the derivatives of the solution function. Further, we extend the results presented in (Franco et al. in Extr. Math. 18(2):153–160, 2003; Franco et al. in Appl. Math. Comput. 153:793–802, 2004; Franco and O’Regan in Arch. Inequal. Appl. 1:423–430, 2003; Asif et al. in Bound. Value Probl. 2015:134, 2015). Finally, as an application, we consider the fully nonlinear coupled mass-spring model.
Hypokalemia in patients with anorexia nervosa during refeeding is associated with binge–purge behavior, lower body mass index, and hypoalbuminemia
Authors: Funayama Michitaka , Mimura Yu , Takata Taketo , Koreki Akihiro , Ogino Satoyuki , Kurose Shin , Shimizu Yusuke 
Published: August 2021

Abstract
Background
Hypokalemia is frequently found in patients with anorexia nervosa and sometimes leads to life-threatening conditions.
Although their serum potassium levels are considered to further decrease during refeeding, no previous studies have addressed actual changes in the serum potassium levels and potential mechanisms underlying hypokalemia during the refeeding period of patients with anorexia nervosa. In this study, we investigated factors associated with hypokalemia during refeeding of patients with anorexia nervosa.

Methods
We recruited 52 independent patients from 89 admissions with anorexia nervosa (body mass index, 13.0 ± 3.3) from the psychiatry unit in Ashikaga Red Cross Hospital during the period from April 2003 to March 2018 and analyzed serum potassium levels at admission. Of the 89 admissions, 66 admissions with > 1-week hospitalization were recruited to determine the lowest potassium levels during the refeeding period. We analyzed these levels with multiple linear regression analysis with explanatory variables, including data upon admission and treatment-related indicators.

Results
The initial serum potassium level of 3.6 ± 0.9 mg/dl decreased to 3.1 ± 0.7 mg/dl at nadir hypophosphatemia, which was observed an average of 2.5 days after admission. A lower serum potassium level at admission and a lower nadir potassium level during refeeding were associated with a lower body mass index, hypoalbuminemia, and binge–purge behavior. Similar results were obtained when the analysis included restrictive or binge–purge types as well as the independent patient group.

Conclusions
Lower body mass index, hypoalbuminemia, and binge–purge behavior might be used as indicators to guide clinical approaches for controlling serum potassium levels in patients with anorexia nervosa during refeeding.

Plain English summary
Hypokalemia, low levels of serum potassium, in patients with anorexia nervosa sometimes leads to life-threatening conditions. Thus, it is of great importance to predict the risk of hypokalemia in patients with anorexia nervosa during the refeeding period. Our study found that hypokalemia in patients with anorexia nervosa during refeeding is associated with a lower body mass index and hypoalbuminemia (low levels of serum albumin), in addition to binge–purge behavior.
Mindfulness-based positive psychology interventions: a systematic review
Authors: Allen Joshua George , Romate John , Rajkumar Eslavath 
Published: August 2021

Abstract
Background
There are hundreds of mindfulness-based interventions in the form of structured and unstructured therapies, trainings, and meditation programs, mostly utilized in a clinical rather than a well-being perspective. The number of empirical studies on positive potentials of mindfulness is comparatively less, and their known status in academia is ambiguous. Hence, the current paper aimed to review the studies where mindfulness-based interventions had integrated positive psychology variables, in order to produce positive functioning.

Methods
Data were obtained from the databases of PubMed, Scopus, and PsycNet and manual search in Google Scholar. From the 3831 articles, irrelevant or inaccessible studies were eliminated, reducing the number of final articles chosen for review to 21. Interventions that contribute to enhancement of eudaimonia, hedonia, and other positive variables are discussed.

Results
Findings include the potential positive qualities of MBIs in producing specific positive outcomes within limited circumstances, and ascendancy of hedonia and other positive variables over eudaimonic enhancement.

Conclusion
In conclusion, exigency of modifications in the existing MBIs to bring about exclusively positive outcomes was identified, and observed the necessity of novel interventions for eudaimonic enhancement and elevation of hedonia in a comprehensive manner.
Novel CSR & novel coronavirus: corporate social responsibility inside the frame of coronavirus pandemic in Greece
Authors: Panagiotopoulos Ioannis 
Published: August 2021

AbstractCorporate Social Responsibility (CSR) becomes popular as big international firms gain more power than states and global issues engender concerns to people from all over the world. The pandemic of novel coronavirus is a current issue of global concern that threats humanity and global economy since the end of 2019. A lot of firms have announced urgent actions to support their employees and the local communities. The present study aims to examine whether the CSR activities of firms due to the pandemic could be categorized either as strategical or tactical CSR. The researcher recognizes the formation of a new kind of CSR called critical CSR as a hybrid between tactical and strategical CSR sharing characteristics from both. The examination of the case of Greece during the pandemic has provided a variety of examples of CSR activities from big Greek international firms that have been processed to support the validity of the reasoning. Finally, the paper delineates this new universal form of CSR born under the critical circumstances of the pandemic and the ensuing economic recession. That fact proves that this crisis could be transformed into a chance for corporations to realize their social role and improve their CSR footprint with the learnings of this pandemic by underlining possible advantages of these urgent CSR actions that could be incorporated into the usual CSR policy of the firms.
Does type and number of used substances affect the severity of illness in patients with substance use disorders?
Authors: Hassan Maha Ali , Abdelhameed Mohamed Ayman , Abd El-Naem Mostafa Mahmoud , Abdelhafeez Mohamed Helmy 
Published: August 2021

AbstractBackgroundSubstance use disorders (SUD) are considered as serious mental illnesses, with variability of age of onset, duration of illness, and type of used substance among patients. The effect of type and number of substances used on the severity of such an illness are worth scientific investigation.In this study, we tried to investigate the probable relationship between type and number of used substances with the degree of severity of substance used disorders in a sample of upper Egyptian patients. To predict risk factors associated with the severity of SUD.ResultsOpiates (including tramadol) were the most frequently used substances followed by cannabis and then heroin. Patients using poly substances scored significantly higher than the ones using a single substance on AIS (p= 0.001), as well as on the legal, drug, and family and social subscales of ASI (0.012 0.006, 0.002 respectively). Multiple stepwise linear regression analysis demonstrated that the number of used substances was the most prominent factor in determining severity of substance-related disorder.ConclusionsUsing more than one substance is common in patients with substance use disorders. This is usually associated in more severe form and consequences of illness. So, some substances and combinations are associated with more morbidity than others.
Prognostic Value of Palliative Prognostic Index for Hospitalized Patients With End-of-Life Hematologic Malignancies in a Japanese University Hospital
Authors: Iizuka-Honma Hiroko , Mitsumori Toru , Yoshikawa Seiichiro , Takizawa Haruko , Noguchi Masaaki 
Published: August 2021

PURPOSE: Uncertainty of prognosis is one reason patients with hematologic malignancies receive aggressive therapy near end of life more often than those with advanced solid tumors. It is unknown whether end-of-life prognosis prediction models are useful for patients with hematologic malignancies, especially hospitalized patients receiving chemotherapy, because most prognostic models were developed for patients with solid tumors. The purpose of this study was to evaluate the prognostic accuracy of the Palliative Prognostic Index (PPI) for end-of-life patients with advanced hematologic malignancies. METHODS: We retrospectively reviewed the records of 143 patients who became resistant to standard chemotherapy and died of disease progression in our university hospital hematology ward between May 2015 and November 2019. Patients were classified according to PPI scores (groups: A, PPI ≤ 2.0; B, 2.0 < PPI ≤ 4.0; and C, PPI > 4.0) based on their clinical charts at admission. The median overall survival for each patient (95% confidence interval) was calculated using the Kaplan-Meier method. Log-rank tests were used to determine significant differences between survival curves. RESULTS: Median patient age was 76 years (range: 39-92 years), and 59% were men. Median overall survival times in the PPI groups A, B, and C were 58 days, 36 days, and 10 days, respectively. Statistically significant differences in survival time were observed between the groups ( P < .01); prediction accuracy was similar to that for patients with different diagnoses. CONCLUSION: The usefulness of PPI was validated for near-end-of-life hospitalized patients with hematologic malignancies.
In vivo human gracilis whole-muscle passive stress–sarcomere strain relationship
Authors: Persad Lomas S. , Binder-Markey Benjamin I. , Shin Alexander Y. , Kaufman Kenton R. , Lieber Richard L. 
Published: August 2021

ABSTRACT
We measured the passive mechanical properties of intact, living human gracilis muscles (n=11 individuals, 10 male and 1 female, age: 33±12 years, mass: 89±23 kg, height: 177±8 cm). Measurements were performed in patients undergoing surgery for free-functioning myocutaneous tissue transfer of the gracilis muscle to restore elbow flexion after brachial plexus injury. Whole-muscle force of the gracilis tendon was measured in four joint configurations (JC1–JC4) with a buckle force transducer placed at the distal tendon. Sarcomere length was also measured by biopsy from the proximal gracilis muscle. After the muscle was removed, a three-dimensional volumetric reconstruction of the muscle was created via photogrammetry. Muscle length from JC1 to JC4 increased by 3.3±1.0, 7.7±1.2, 10.5±1.3 and 13.4±1.2 cm, respectively, corresponding to 15%, 34%, 46% and 59% muscle fiber strain, respectively. Muscle volume and an average optimal fiber length of 23.1±0.7 cm yielded an average muscle physiological cross-sectional area of 6.8±0.7 cm2 which is approximately 3 times that measured previously from cadaveric specimens. Absolute passive tension increased from 0.90±0.21 N in JC1 to 16.50±2.64 N in JC4. As expected, sarcomere length also increased from 3.24±0.08 µm at JC1 to 3.63±0.07 µm at JC4, which are on the descending limb of the human sarcomere length–tension curve. Peak passive muscle stress was 27.8±5.5 kPa in JC4 and muscle modulus ranged from 44.8 MPa in JC1 to 125.7 MPa in JC4. Comparison with other mammalian species indicates that human muscle passive mechanical properties are more similar to rodent muscle than to rabbit muscle. These data provide direct measurements of whole-human muscle passive mechanical properties that can be used in modeling studies and for understanding comparative passive mechanical properties among mammalian muscles.
Physical Activity in the Treatment and Prevention of Heart Failure: An Update
Authors: LaMonte Michael J. , Eaton Charles B. 
Published: August 2021

Abstract
Heart failure (HF) is a complex clinical syndrome hallmarked by an inability to match cardiac output with metabolic demand, resulting in exercise intolerance. HF is increasingly prevalent in an aging population and accounts for substantial burden of health care costs and morbidity. Because many of the central and peripheral mechanisms of HF respond favorably to exercise training, its role in HF treatment is becoming established. The role of habitual physical activity in the primary prevention of HF is less clear; however, available evidence is supportive. This article reviews recently published studies on exercise training and usual physical activity in HF treatment and prevention, discusses potential mechanisms, and suggests areas where further research is needed.
Boesenbergia pandurata application in Goldfish (Cyprinus carpio) Feed to Enhancing Fish Growth, Immunity System, and Resistance to Bacterial Infection
Authors: Hardi Esti Handayani , Saptiani Gina , Nugroho Rudi Agung , Rahman fadlul , Sulistyawati Sulistyawati , Rahayu Widyaningsih , Supriansyah Ali , Kusuma Irawan Wijaya 
Published: August 2021

Background: This study investigated how the inclusion of Boesenbergia pandurata extract (BPE) in goldfish feed affects fish growth, immunity, and resistance to infection by Aeromonas hydrophila and Pseudomonas fluorescens. Methods: Four fish feeds, were prepared by adding BPE at the concentrations of 0 (control), 2, 4, and 6 g kg-1, respectively, and 120 goldfish (Cyprinus carpio; initial weight 5 g) were separated into 12 boxes and fed with specific pellets and examined thrice. The experiment lasted 12 weeks, beginning with the different feeds, fish growth was measured at Weeks 4 and 8 after the feeding period. Moreover, a challenge test with pathogen bacteria to assay disease resistance was administered at Week 8 after the feeding period, and the survival rate and relative percentage of survival were quantified at Week 12. Results: At Week 8, the goldfish that were fed BPE-containing feeds were significantly heavier than the fish that received the control feed (pellet without BPE), and the highest weight gain, reaching 72.44 g, was obtained with Pellet 3; accordingly, the specific growth rate after BPE treatment (5.7%) was higher than that after control treatment. Conversely, the feed conversion ratio in the control group, 2.03, was higher than the ratios in the BPE groups, which were decreased to 0.55–0.90. Lastly, BPE treatment consistently enhanced the immunity parameters of goldfish (relative to control treatment) at weeks 4 and 8, and following BPE treatment, the rate of resistance against bacterial infection, 68.3%–77.0%, was higher than that after control treatment. Conclusions: BPE addition in goldfish feed clearly produces a positive effect by enhancing fish growth, immunity, and resistance to infection by pathogenic bacteria, and 4 g kg-1 is the optimal BPE concentration in feed prepared for goldfish.