bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solving nonlinear third-order boundary value problems based-on boundary shape functions
Authors: Liu Chein-Shan , Chang Jiang-Ren 
Published: May 2021

Abstract
For a third-order nonlinear boundary value problem (BVP), we develop two novel methods to find the solutions, satisfying boundary conditions automatically. A boundary shape function (BSF) is created to automatically satisfy the boundary conditions, which is then employed to develop new numerical algorithms by adopting two different roles of the free function in the BSF. In the first type algorithm, we let the BSF be the solution of the BVP and the free function be a new variable. In doing so, the nonlinear BVP is certainly and exactly transformed to an initial value problem for the new variable with its terminal values as unknown parameters, whereas the initial conditions are given. In the second type algorithm, let the free functions be a set of complete basis functions and the corresponding boundary shape functions be the new bases. Since the solution already satisfies the boundary conditions automatically, we can apply a simple collocation technique inside the domain to determine the expansion coefficients and then the solution is obtained. For the general higher-order boundary conditions, the BSF method (BSFM) can easily and quickly find a very accurate solution. Resorting on the BSFM, the existence of solution is proved, under the Lipschitz condition for the ordinary differential equation system of the new variable. Numerical examples, including the singularly perturbed ones, confirm the high performance of the BSF-based numerical algorithms.
CaMKIV Signaling Is Not Essential for the Maintenance of Intrinsic or Synaptic Properties in Mouse Visual Cortex
Authors: Trojanowski Nicholas F. , Turrigiano Gina G. 
Published: May 2021

AbstractPyramidal neurons in rodent visual cortex homeostatically maintain their firing ratesin vivowithin a target range. In young cultured rat cortical neurons, Ca2+/calmodulin-dependent kinase IV (CaMKIV) signaling jointly regulates excitatory synaptic strength and intrinsic excitability to allow neurons to maintain their target firing rate. However, the role of CaMKIV signaling in regulating synaptic strength and intrinsic excitabilityin vivohas not been tested. Here, we show that in pyramidal neurons in visual cortex of juvenile male and female mice, CaMKIV signaling is not essential for the maintenance of basal synaptic or intrinsic properties. Neither CaMKIV conditional knock-down nor viral expression of dominant negative CaMKIV (dnCaMKIV)in vivodisrupts the intrinsic excitability or synaptic input strength of pyramidal neurons in primary visual cortex (V1), and CaMKIV signaling is not required for the increase in intrinsic excitability seen following monocular deprivation (MD). Viral expression of constitutively active CaMKIV (caCaMKIV)in vivocauses a complex disruption of the neuronal input/output function but does not affect synaptic input strength. Taken together, these results demonstrate that although augmentedin vivoCaMKIV signaling can alter neuronal excitability, either endogenous CaMKIV signaling is dispensable for maintenance of excitability, or impaired CaMKIV signaling is robustly compensated.
Impact Of Strain Rate On Mechanical Properties Of Metallic Sheets At Various Temperatures
Authors: Et. al. Dr BVS Rao, 
Published: May 2021

It is known that in warm and hot forming processes, the forming speed and with-it combined strain rate has immense role on material flow in bulk and sheet metal operations. In contrast, the influence of the strain rate on the flow curve has been rarely analysed at room temperature. This work analyses the influence of strain rate on flow curve of bimetallic sheets, Copper and Aluminium metals. Evaluation of the flow curve is carried out as a function of strain rate. In this work three different strain rates are considered for three different materials viz bimetallic sheets(Cu-Al), Copper and Aluminium. In addition to this ,the evaluation of flow curve at elevated temperatures is carried out. The Variation of mechanical properties with strain rate are plotted and analysed.
Hastanede yatan COVID-19 hastalarında elektrokardiyografik bulgular ve hidroksiklorokin + azitromisin tedavisinin kardiyak güvenliği
Authors: AKKUŞ Oğuz , BAL Tayibe , YAGOOBİ Hasibullah , BEKLER Özkan , AKKUŞ Gamze , ÇABALAK Mehmet 
Published: May 2021

Amaç: Bu çalışma ile COVID-19 hastalarında 12-derivasyonlu elektrokardiyografinin (EKG) standart değerlendirmesine ek olarak yeni aritmi belirteçlerini ve tedavi etkisininin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Toplam 51 COVID-19 hastasının 12-derivasyonlu EKG si tedavi öncesi, tedavinin 2. ve 5. günlerinde geriye dönük olarak değerlendirildi. Hastalar COVID-19’a yönelik hidroksiklorokin (HCQ) + azitromisin veya sadece HCQ tedavisi aldı. Ciddi COVID-19 hastaları, pnömoni bulgularına ek olarak SpO230/dk olarak tanımlandı.
Bulgular: Hastaların %68,6’ı HCQ + azitromisin kombinasyon tedavisi alırken, %31,4 hasta sadece azitromisin tedavisi aldı. Tedavinin 2. gününde, kombinasyon tedavisi alanlarda ve sadece azitromisin alanlarda sadece kalp hızı istatistiksel olarak anlamlı değişken olarak bulundu. Tedavinin 5. gününde kalp hızına ek olarak ve cTpe değerleri her iki tedavi rejiminde istatistiksel olarak anlamlı olarak bulundu. Tedavi süresince her iki tedavi rejiminde Tpe düzeyleri istatistiksel anlamlı olarak artmasına rağmen, rölatif artış oranları istatistiksel olarak gruplar arası benzer bulundu.
Sonuç: Çalışma sonuçlarımız, kısa süreli hastanede yatan COVID-19 hastalarında kullandığımız HCQ/ azitromisin tedavisinin kabul edilebilir düzeyde kardiyak etki profiline sahip olduğunu göstermektedir.
Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality
Authors: AVCİ Begüm Şeyda , KAYA Adem , SÜMBÜL Hilmi Erdem , İÇME Ferhat , YEŞİLAĞAÇ Hasan , ÜNAL Nevzat , YEŞİLOĞLU Önder , ÇINAR Hayri , TURUNÇ Tuba 
Published: May 2021

Purpose: In the present study, the possibility of predicting mortality with the change in coagulation parameters depending on the severity of Covid-19-associated pneumonia was investigated.
Materials and Methods: A total of 137 patients with Covid-19-associated pneumonia were included in the study. The patients were divided into three groups according to the severity of pneumonia as mild, moderate and severe. According to the severity of pneumonia, the parameters of complete blood count and the levels of biochemical parameters were compared between the groups. By examining blood parameters according to mortality, ROC analysis and regression analysis were performed to determine the net effect of these parameters on mortality.
Results: As the severity of pneumonia increased, Prothrombin time (PT), International normalized ratio (INR) and Activated partial thromboplastin time (aPTT) values were also increased, and a statistically significant difference was found between the groups in PT and INR values. PT, INR and aPTT levels were higher in cases with mortality. Mortality can be predicted with 93.5% sensitivity and 97.5% specificity. according to the >45.1 seconds(sec) cut-off value of the coagulation parameter (aPTT+PT.
Conclusion: The coagulation parameter (aPTT + PT), whose level increases secondarily to the increase in Covid-19-associated pneumonia severity, provides successful results in predicting mortality, and may be a parameter that we can recommend in clinical use.
Comparison of energy consumptions measured by metabolic monitor with standard equations in intensive care patients
Authors: KARAKOÇ Emre , TAKTAKOĞLU Onur , ERDOGAN Murat 
Published: May 2021

Purpose: The aim of this study was to determine parameters affecting the energy consumption in intensive care patients, and the most reliable formulas for calculation of energy consumption.
Materials and Methods: This prospective study was carried out in the intensive care unit of the Internal Medicine Department of Çukurova University Hospital. Total 71 patients above 18 years of age, with hemodynamical and respirational stability, and being followed up on a mechanical ventilator for more than 24 hours, were included to this study. We analyzed the correlation of calculated energy consumption values obtained from formulas, with the energy consumption values measured by indirect calorimeter.
Results: The study was executed on 71 patients. The mean energy consumption of the patients was 2078±794 kcal and the mean energy need per kilogram was found as 31.64±13.82 kcal. Indirect calorimeter measurements showed the strongest correlation with Swinamer formula.
Conclusion: Indirect calorimetry has become not only a "gold standard" but an "achievable gold standard" in determining energy consumption. We recommend that the indirect calorimeter method should be used in intensive care patients to maintain nutrition properly. Under conditions where indirect calorimeter cannot be used, or it is not desirable to wait for 24 hours; feeding can be started according to the results of a 2-hour measurement, or reliable predictive equations.
Antidepresanların ilaç ilişkili hareket bozuklukları ve cinsel yan etkiler açısından karşılaştırılması
Authors: NAMLI Zeynep , TAMAM Lut , DEMİRKOL Mehmet Emin , KARAYTUĞ Mahmut Onur , UĞUR Kerim , ERİŞ Özge 
Published: May 2021

Amaç: Çalışmamızda farklı antidepresan gruplarının cinsel yan etkiler, daha az bilinen uyku bruksizmi ve nörolojik yan etkiler açısından karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmanın örneklem grubunu 18-50 yaş aralığında, depresif bozukluklar ve/veya anksiyete bozuklukları tanısı ile ayaktan tedavi gören, 1 aydan uzun süredir antidepresan monoterapisi alan 406 hasta oluşturmaktadır. Tüm hastalara; sosyodemografik veri formu, Hamilton Depresyon Ölçeği (HAM-D), Hamilton Anksiyete Ölçeği (HAM-A), UKU Yan Etki Değerlendirme Ölçeği nörolojik yan etkiler bölümü, Arizona Cinsel Yaşantılar Ölçeği (ACYÖ) ve Morisky İlaç Uyum Ölçeği uygulanmıştır. Kullanılan antidepresanlar; seçici serotonin geri alım inhibitörleri (SSGİ), serotonin norepinefrin geri alım inhibitörleri (SNGİ ve vortioksetin olmak üzere üç gruba ayrılarak karşılaştırılmıştır.
Bulgular: YAB tanılı hastalarda SNGİ kullananların UKU nörolojik yan etkiler ortalama puanı SSGİ kullananlardan anlamlı olarak yüksek belirlendi. Depresif bozukluk tanılı hastalarda; ilaç tedavisine yeterli uyum sırasıyla %91.3 oranında vortioksetin, % 73.8 oranında SSGİ ve %50 oranında SNGİ kullanan hastalarda belirlendi ve üç grup arasındaki fark istatistiksel olarak anlamlıydı.
Sonuç: Antidepresan ilaç grupları bazı yan etkiler ve tedavi uyumu açısından birbirinden farklılık gösterebilmektedir. Antidepresan kaynaklı uyku bruksizmi ve hareket bozuklukları gibi daha az bilinen yan etkilerin daha iyi anlaşılması için prospektif çalışmalara ihtiyaç bulunmaktadır.
Patient satisfaction on nursing care: the case of in day surgery
Authors: GEZER Derya , ARSLAN Sevban 
Published: May 2021

Purpose: The study was conducted to assess day surgery patients’ satisfaction levels with nursing care.
Materials and Methods: The study used a descriptive and cross-sectional design and was carried out through face-to-face interviews between January and March 2016 with 98 patients who were hospitalized in the day surgery unit of a university hospital, who were 18 years or older, spoke Turkish and were able to comprehend and answer the questions, and volunteered to take part in the study. A personal questionnaire containing questions about the patients' descriptive characteristics, and the Newcastle Satisfaction with Nursing Scales (NSNS), adapted into Turkish by Uzun, were used to collect the data.
Results: The patients’ mean age in the study was 6.2±14.5 and 56.1% of them were women. The mean score of the Experience of Nursing Care Scale (ENCS) applied to the patients was 84.4±18.1 and the Satisfaction with Nursing Care Scale’s (SNCS) mean score was 82.4±19.2. The satisfaction level in surgical clinic patients was high in a statistically significant manner. There was a positive statistically significant correlation and between mean scores of the patients in ENCS and SNCS. The scores of the scales range from 0 to 100 points. A total score of 100 points indicate the highest satisfaction with all aspects of nursing care.
Conclusion: It was determined that the patients' nursing care experience and nursing care satisfaction scores were high, and as the care experience total score increased, the nursing care satisfaction score increased.
Lack of association between serum IL-25 levels and acute coronary syndrome: a preliminary study
Authors: Naderi Nadereh , Farshidi Narges , Farshidi Hossein , Montazerghaem Hossein , Rahimzadeh Mahsa 
Published: May 2021

Purpose Here, for the first time, the possible association between IL-25 and the risk of acute coronary syndrome (ACS) in Iranian patients was investigated.Material and methods In this study, serum IL-25 concentrations were measured with an enzyme-linked immunosorbent assay in 88 ACS patients, 40 stable angina pectoris (SAP) patients, and 50 healthy control subjects.Results No significant differences in IL-25 concentrations were observed between SAP (340±168 ng / l), ACS (330±151 ng / l), and control (302±135 ng / l) groups (p=0.5), nor was there a difference among patients with 1, 2, or 3 vessel disease in the SAP and ACS groups. Linear regression analyses revealed that IL-25 was not correlated with coronary artery disease risk factors. Biochemical and demographic variables did not differ significantly among IL-25 quartiles.Conclusion Despite previous murine and human studies showing a protective role of IL-25 in atherosclerosis, our results revealed that IL-25 does not have potential implications for atherosclerosis development and management in humans.
Głoszenie słowa Bożego do mężczyzn
Authors: Twardy Jan 
Published: May 2021

W XIX i XX w. o kazaniach do mężczyzn pisano ogólnie w ramach teorii misji i rekolekcji parafialnych. Szerzej ujęli ten problem ks. Szczepan Sobalkowski i ks. Ferdynand Machay. Homileci wskazywali na potrzebę akcentowania obowiązków stanowych mężczyzn, podkreślając ich cechy pozytywne i negatywne oraz metody oddziaływania kaznodziei na tych słuchaczy. Autor artykułu podkreśla, że mężczyzna jest powołany do życia chrześcijańskiego, powinien się modlić i dążyć do doskonałości. Omawiając jego powołanie do życia w małżeństwie i rodzinie, uwydatnił znaczenie miłości i troski o życie. Zaproponował wskazania dla mężczyzn samotnych i w podeszłym wieku. Zwrócił uwagę na takie okoliczności głoszenia słowa Bożego do mężczyzn, jak misje i rekolekcje, niedziele i święta, dni patronalne różnych zawodów czy pielgrzymki. Celowe jest m.in. rozwijanie refleksji na temat roli mężczyzny w rodzinie, narodzie i Kościele.
TINGKAT KESEJAHTERAAN PETANI SAYURAN ORGANIK DI KECAMATAN KEDUNGBANTENG KABUPATEN BANYUMAS
Authors: Utami Nur Istia , Widyarini Indah , Satriani Ratna 
Published: May 2021

Kecamatan Kedungbanteng merupakan daerah sentra produksi sayuran organik di Kabupaten Banyumas. Harga jual yang tinggi dari produk organik akan memberikan tingkat pendapatan dan kemampuan petani dalam memenuhi kebutuhan dasarnya untuk mencapai kesejahteraan rumah tangga petani. Penelitian ini bertujuan untuk mengetahui : 1) pendapatan yang diterima petani dalam usahatani sayuran organik dan kontribusinya terhadap pendapatan total rumah tangga petani; 2) distribusi pendapatan petani; 3) tingkat kesejahteraan rumah tangga petani sayuran organik di Kecamatan Kedungbanteng. Penelitian ini dilaksanakan di desa Melung dan desa Windujaya kecamatan Kedungbanteng pada bulan September hingga Oktober 2019. Metode penelitian yang digunakan adalah metode survei. Penentuan responden menggunakan metode sensus diperoleh 18 orang petani sayur organik. Analisis yang digunakan yaitu analisis pendapatan usahatani, analisis kontribusi pendapatan, analisis distribusi pendapatan, dan analisis tingkat kesejahteraan. Hasil penelitian menunjukkan bahwa: 1) pendapatan usahatani sayuran organik yang diterima petani yaitu Rp7.892.252,00 per tahun dan kontribusinya terhadap pendapatan total sebesar 20,23%; 2) kondisi pemerataan pendapatan petani sayuran organik di kecamatan Kedungbanteng tidak merata; 3) rumah tangga petani sayuran organik di kecamatan Kedungbanteng tergolong sejahtera. Kata kunci: petani sayur organik, pendapatan, kontribusi pendapatan, distribusi pendapatan, dan kesejahteraan.
Play Teach Play: Pengaruhnya Terhadap Kemampuan Passing Futsal
Authors: Agustan Boby , Hidayat Ahmad Roni 
Published: May 2021

Model Play Teach Play menjadi salah satu model pembelajaran yang perlu dikembangkan pada pembelajaran permainan futsal di sekolah. Tujuan dari penelitian ini yaitu untuk mengetahui peningkatan kemampuan passing dalam permainan futsal melalui model pembelajaran play teach play. Metode penelitian yang digunakan adalah eksperimental, dengan desain penelitian yaitu pre-eksperimental one group pretest-posttest design. Sampel siswa sebanyak 18 orang dengan menggunakan teknik purposive sampling. Teknik pengumpulan data dilakukan dengan pre-test, treatment dan posttest. Instrumen penelitian mengunakan tes passing futsal yang sudah terstandar. Teknik analisis data menggunakan SPSS dengan melalui uji normalitas, uji homogenitas, dan uji hipotesis. Hasil menunjukkan bahwa terdapat pengaruh model pembelajaran play teach play terhadap kemampuan passing siswa dalam permainan futsal. Model pembelajaran play teach play efektif untuk diterapkan dalam pembelajaran penjas dengan materi olahraga permainan, khusunya futsal. Penelitian selanjutnya dapat menerapkan model pembelajaran lain dan bahkan membandingkan antar dua model berbeda untuk mengetahui peningkatkan keterampilan teknik dasar dalam permainan futsal.
Treatment of Chondroblastoma with Denosumab
Authors: Visgauss Julia D. , Lazarides Alex , Dickson Brendan , Cardona Diana , Sheth Maya , DeWitt Suzanne Bartholf , Somarelli Jason A. , Eward William C. 
Published: May 2021

Case:
A 15-year-old boy with chondroblastoma of the right hemipelvis presented with significant periacetabular bone destruction. Neoadjuvant denosumab treatment facilitated initial joint preserving surgery. Unfortunately, he experienced 2 local recurrences and underwent wide surgical resection 2 years after his initial diagnosis.

Conclusion:
Inhibition of the receptor activator of NF-κB (RANK)/RANK ligand (RANK-L) pathway with denosumab has been used neoadjuvantly for the treatment of giant cell tumor of bone, but its role in the treatment of chondroblastoma is less understood. This patient's clinical response and effect on cellular RANK/RANK-L activity support the consideration of denosumab in the treatment algorithm for other osteolytic bone tumors such as chondroblastoma.
Perioperative Pain Management in Ambulatory and Inpatient Shoulder Surgery
Authors: Zangrilli Julian , Szukics Patrick , Austin Luke , Horneff John G. 
Published: May 2021

» Acetaminophen is an effective addition to a multimodal pain regimen; however, evidence to support intravenous versus oral administration requires further evaluation.» While nonsteroidal anti-inflammatory drugs are a valuable addition to a multimodal pain strategy, concerns regarding their effect on healing after certain procedures (i.e., rotator cuff repair) in select patients may preclude their use.» The use of perioperative gabapentinoids have varied results for pain control, and additional research is warranted to support their use after certain shoulder procedures.» Opioid-prescribing should be limited and reserved for severe postoperative pain. When prescribed, opioids should be taken at the lowest possible dose and for the shortest period.» Centrally acting analgesics such as tramadol have been shown to be as effective as opioids and have a lower risk of complications.» Nerve blocks are an excellent addition to multimodal pain management strategies. Longer-lasting formulations of perioperative single-shot injections and indwelling catheters may reduce rebound pain.
Elective Orthopaedic Surgery in the Era of COVID-19
Authors: Kucharik Michael P. , Rudisill Samuel S. , Meek Wendy M. , Martin Scott D. 
Published: May 2021

» The COVID-19 pandemic has forced hospitals in the United States to postpone elective orthopaedic surgery, which has financially impacted health-care systems and left patients vulnerable to increased morbidity.» In combination with the Centers for Medicare & Medicaid Services (CMS) and the Centers for Disease Control and Prevention (CDC) recommendations, the American Academy of Orthopaedic Surgeons (AAOS) guidelines should be utilized to stratify orthopaedic conditions into 4 tiers in order to properly define which surgeries are elective.» Recommendations released by the American Association of Hip and Knee Surgeons (AAHKS) and the American College of Surgeons (ACS) have encouraged a checklist approach for implementing a safe return to elective orthopaedic surgery, and include both regional and facility-specific recommendations.» When determining patient eligibility and priority for elective orthopaedic surgery, a standardized virtual orthopaedic examination via telemedicine can be used alongside the European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) guidelines, which detail a 4-phase strategy that is based on age, comorbidities, type of surgery, and expected length of hospital stay.» To ensure a safe, sustainable return to surgery and sufficient patient safety, hospital administrators should be aware of preoperative, intraoperative, and postoperative considerations according to the current state of knowledge on COVID-19.