bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prone transpsoas lumbar corpectomy: simultaneous posterior and lateral lumbar access for difficult clinical scenarios
Authors: Gandhi Sapan D. , Liu David S. , Sheha Evan D. , Colman Matthew W. 
Published: August 2021

OBJECTIVE
Lateral lumbar corpectomy with interbody fusion has been well described via a transpsoas approach in the lateral position, as has lumbar interbody fusion with posterior fixation in the prone position. However, no previous report has described the use of both an open posterior approach and a lateral transpsoas approach simultaneously in the prone position. Here, the authors describe their technique of performing transpsoas lumbar corpectomy in the prone position in order to have simultaneous posterior and lateral access for difficult clinical scenarios, and they report their early clinical experience.

METHODS
The surgical technique for simultaneous posterior and lateral transpsoas access to the lumbar spine was reviewed and described in detail. The cases of 2 patients who underwent simultaneous posterior and lateral access in the prone position for complex lumbar pathology were retrospectively reviewed. Clinical presentation, preoperative radiographs, postoperative course, and postoperative radiographs were reviewed.

RESULTS
The first patient presented after previous transforaminal lumbar interbody fusion that was complicated by significant subsidence of the intervertebral cage, vertebral body split fracture, rotational instability, and resulting spinal stenosis. A simultaneous posterior and lateral transpsoas approach in the prone position allowed for removal of the previous cage, lumbar corpectomy, and rigid posterior fixation with direct decompression. The second patient had a significant pathologic burst fracture secondary to a plasmacytoma with retropulsion, resulting in vertebra plana and significant canal stenosis. Simultaneous approaches allowed for complete resection of the plasmacytoma, restoration of lumbar alignment, rigid fixation, and direct posterior decompression. There were no short-term complications, and both patients had resolution of their preoperative symptoms.

CONCLUSIONS
Simultaneous posterior and lateral transpsoas access to the lumbar spine in the prone position is a previously unreported technique that allows a safe surgical approach to difficult clinical scenarios.
Comparison of transorbital ultrasound measurements to predict intracranial pressure in brain-injured patients requiring external ventricular drainage
Authors: Youm Jin Young , Lee Jae Hoon , Park Hyun Seok 
Published: August 2021

OBJECTIVE
The optic nerve sheath diameter (ONSD) excluding the dura mater (ONSDE; i.e., the subarachnoid diameter) and the ONSD including the dura mater (ONSDI) have been used differently in studies, but the predictive ability of these two different measurements of the ONSD as measured by invasive intracranial pressure (ICP) monitoring has never been compared. Additionally, studies on the prediction of ICP using central retinal artery (CRA) Doppler ultrasonography are scarce. The authors aimed to determine how the two different ONSD measurements, the ONSD/eyeball transverse diameter (ETD) ratio, and transorbital Doppler ultrasonography parameters are associated with ICP via external ventricular drainage (EVD).

METHODS
This prospective observational study included 50 patients with brain injury who underwent EVD between August 2019 and September 2020. The mean of three repeated measurements of the ONSDI and ONSDE was calculated to reduce artifact and off-axis measurements. ETD, an immutable value, was measured from the initial brain CT with a clear outline of the eyeball. Simultaneously, flow velocities in the CRA and posterior ciliary artery (PCA) were compared with the ICP.

RESULTS
The ONSDE, ONSDI, and ONSD/ETD ratio were significantly associated with ICP (p = 0.005, p < 0.001, and p < 0.001, respectively). The ONSD/ETD ratio showed the highest predictive power of increased ICP (area under the curve [AUC] 0.897). The ONSDI was correlated more with the ICP than was the ONSDE (AUC 0.855 vs 0.783). None of the Doppler ultrasonography parameters in the CRA and PCA were associated with ICP.

CONCLUSIONS
The ONSD/ETD ratio is a better predictor of increased ICP compared with the ONSDI or ONSDE in brain-injured patients with nonsevere ICP. The ONSDI may be more available for predicting the ICP than the ONSDE.
External lumbar drainage in progressive pediatric idiopathic intracranial hypertension
Authors: Dotan Gad , Hadar Cohen Natalie , Qureshi Hanya M. , Shapira Rootman Mika , Nevo Yoram , Kershenovich Amir 
Published: August 2021

OBJECTIVE
Pediatric idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure despite normal cerebrospinal fluid and neuroimaging findings. Initial management is typically medical; however, nearly 10% of children will eventually require surgery for persistent headache and/or vision loss. External lumbar drainage, which is a considerably safer treatment option, has not been adequately analyzed in children with medically refractory IIH.

METHODS
The authors conducted a single-institution retrospective analysis of children with medically refractory IIH who had undergone external lumbar drain (ELD) placement because of worsening papilledema, reflected as increased retinal nerve fiber layer (RNFL) thickness on optical coherence tomography (OCT) testing. The main outcome measures were effects of external lumbar drainage on papilledema resolution, symptoms, and vision.

RESULTS
The authors analyzed the medical records of 13 children with IIH (11 girls, mean age 15.0 ± 2.3 years) whose mean CSF opening pressure was 45.5 ± 6.8 cm H2O. In all children, the average global RNFL thickness in both eyes significantly increased at ELD placement (right eye 371.8 ± 150.2 μm, left eye 400.3 ± 96.9 μm) compared with presentation thickness (right eye 301.6 ± 110.40 μm, left eye 350.2 ± 107.7 μm) despite acetazolamide medical therapy (20–30 mg/kg/day), leading to ELD placement after 9.5 ± 6.9 days (range 3–29 days). After ELD insertion, there was headache resolution, gradual and continuous improvement in optic disc thickness, and preservation of good vision.

CONCLUSIONS
ELD placement in children with medically refractory IIH who demonstrated worsening papilledema with increased RNFL thickening on OCT testing typically results in symptom relief and disc edema resolution with good visual outcome, often preventing the need for additional definitive surgeries that carry greater failure and morbidity risks.
Efektivitas Dan Kontribusi Penerimaan Bea Perolehan Hak Atas Tanah Dan Bangunan Dalam Rangka Peningkatan Pendapatan Asli Daerah di Kabupaten Gunung Kidul
Authors: Tatik Tatik , Maharani Yestias , Farah HH Zulfa , Barmawi Muhammad Manar 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui efektivitas dan kontribusi penerimaan BPHTB (Bea Perolehan Hak Atas Tanah dan Bangunan) dalam rangka peningkatan pendapatan asli daerah. BPHTB merupakan pajak atas perolehan hak tanah dan bangunan baik oleh pribadi maupun badan. Penelitian menggunakan metode kualitatif dengan pendekatan studi kasus pada Kabupaten Gunung Kidul - Yogyakarta. Data diperoleh dari dokumen dan wawancara. Informan/narasumber berasal dari berbagai pihak yang kompeten memberikan informasi yang diperlukan. Hasil penelitian ini menunjukkan bahwa penerimaan Bea Perolehan Hak Atas Tanah dan Bangunan di Kabupaten Gunung Kidul dapat dikategorikan cukup efektif, namun kontribusi dari Bea Perolehan Hak Atas Tanah dan Bangunan terhadap Pendapatan Asli Daerah (PAD) masih sangat kurang.
Kata Kunci: Efektivitas, Kontribusi, Pajak, Pendapatan Asli Daerah
Profil Petani Dan Kelayakan Usahatani Gula Aren Di Negeri Tuhaha Kecamatan Saparua Timur Kabupaten Maluku Tengah
Authors: Mey Laukoun  
Published: August 2021

Aren (Arenga pinnata Merr) adalah salah satu jenis tanaman perkebunan yang diolah masyarakat Indonesia untuk memenuhi kebutuhan hidup mereka. Aren merupakan jenis palma yang memiliki nilai ekonomis yang cukup tinggi, penyebarannya sangat luas di Indonesia. Penelitian ini bertujuan untuk 1) Mengetahui profil petani pengusaha gula aren di Negeri Tuhaha; 2) Mengetahui kelayakan usahatani gula aren di Negeri Tuhaha. Metode pengambilan dengan teknik penarikan contoh acak sederhana terhadap 10% dari jumlah petani. Analisis data menggunakan metode analisis pendapatan dan investasi. Hasil penelitian menunjukan bahwa: 1) Petani pengolah gula aren di Negeri Tuhaha memiliki karakteristik yang berbeda-beda. Tingkat umur pelaku usaha berada pada kisaran 15-64 tahun dengan jumlah 15 orang responden atau sebanyak 75 persen,; 2) Berdasarkan analisis kelayakan, maka suatu usaha industri pengolahan gula aren di Negeri Tuhaha, Kecamatan Saparua Timur, Kabupaten Maluku Tengah layak diusahakan secara finansial karena dilihat dari NPV yang diperoleh pada seluruh responden usahatani gula aren.
Estrategias de comunicación para enfrentar el ciberacoso en el contexto del COVID-19
Authors: Erazo Rodríguez Miriam Elizabeth , Viñan Carrasco Luis Miguel , Murillo Naranjo Myriam Elizabeth , Jiménez Granizo Cristhy Nataly 
Published: August 2021

Introducción: Las nuevas tecnologías y el uso del internet forman parte de nuestra cotidianidad; transforman el lenguaje, la vida y las prácticas tradicionales. La aparición del COVID-19 ha mermado las relaciones sociales, y la población mundial enfrenta otros tipos de interacción en todos los ámbitos. El aprendizaje indudablemente es uno de los elementos que ha tenido que migrar de los contextos presenciales a los entornos digitales, donde las relaciones entre los usuarios presentan situaciones de riesgo, como es el caso del acoso digital; existen estudios respecto al ciberacoso en el entorno educativo, pero se desconocen los tipos de estrategias que se usan de acuerdo con el nivel del problema. Objetivo: Definir estrategias de comunicación frente al acoso digital en el contexto del COVID-19. Metodología: El estudio es descriptivo, cuali-cuantitativo, diseño no experimental (transaccional), se realizó una revisión de la literatura a través de la etnografía virtual para definir la accesibilidad y facilidad del uso de páginas web y redes sociales, para recopilar información acerca de las estrategias comunicativas, se aplicó la encuesta online, con una fiabilidad del 0,815, muestra de 247 expertos de la comunicación social que laboran en la zona centro del Ecuador, el análisis de las frecuencias y el Alfa de Cronbach mediante el software SPSS-25. Resultados: Resaltan la interacción forzada, habilidades para el uso herramientas multimedia y la alteración de contenidos por parte del acosador. Las estrategias de los comunicadores enfatizan: Educación (contenidos audiovisuales), Prevención (monitorización de las cuentas para evitar la suplantación), Evasión (no reaccionar a los comentarios del agresor para reducir el riesgo), Aceptación (aceptar lo solicitado por el acosador), Enfrentamiento (recopilación de evidencias). Conclusión: Las estrategias que usan los comunicadores sociales se enfocan en la prevención y llegan hasta el enfrentamiento para afrontar el ciberacoso de acuerdo con el nivel del problema.
Cuidados a criança com câncer frente a pandemia de COVID-19: Revisão integrativa da literatura
Authors: Alves Minuchy Mendes Carneiro , Rodrigues Ayane , Leitão Ana Cecília Sales Barreto , Lourinho Lídia Andrade 
Published: August 2021

A revisão integrativa tem sido uma ferramenta importante para as pesquisas na área de conhecimento da saúde uma vez que permite a síntese de pesquisas sobre determinado assunto. Inúmeros desafios de controle da disseminação da COVID-19 repercutiram no modo da população compreender todas as medidas de segurança propostas pelos órgãos de saúde pública principalmente no que se refere a transmissão. E, nesse cenário pandêmico, as crianças não são poupadas, apesar de serem menos vulneráveis ao adoecimento por esse agravo, no entanto, podem ter infecção assintomática e a eliminação do vírus nas secreções respiratórias e nas fezes parece ser mais longa do que nos adultos, o que pode contribuir para a disseminação da COVID-19. Desta forma, este estudo tem como objetivo: Realizar uma revisão integrativa de literatura sobre as principais recomendações de cuidados a criança com câncer para reduzir agravos e complicações nesse contexto da pandemia da COVID-19. A pesquisa englobou a busca e a seleção de artigos nacionais e internacionais publicados no período de 2020 a 2021. A busca dos artigos foi realizada nas bases de dados PubMed, CINAHL e Scopus. Os resultados da analise evidenciaram as principais recomendações estão voltadas a minimizar a ida destas crianças ao hospital para consultas de retorno ou monitoramento, ficando evidente o uso da telemedicina como principal recurso a fim de evitar a contaminação pelo novo coronavírus, o acompanhamento por testes rápidos para COVID-19 também foi bastante utilizado, redução do número de acompanhantes no hospital e uso de equipamentos de proteção como máscaras para profissionais, pacientes e acompanhantes, alguns estudos relataram que os tratamentos quimioterápicos deveriam ser suspensos, assim como cirurgias oncológicas eletivas, até que o risco de contaminação reduzisse, monitoramento dos profissionais nos setores oncológicos quanto a sinais de infecção pela covid, consultas online e monitoramento domiciliar foram também estratégias citadas. Conclui-se que as principais recomendações envolviam proteger as crianças que já estão imunocomprometidas pela própria comorbidade que é o câncer da COVID-19, e para isso diversas instituições que trabalham com esse público fizeram uma troca de saberes e relatos de experiencias para que os outras pudessem seguir como exitosas.
Librarian E-Readiness in the Disruption 4.0 Era
Authors: Sasmita Surya Adi 
Published: August 2021

In the era of disruption of the industrial revolution 4.0 as it is today, there are almost no difficulties in meeting information needs. Both information that is educational or information that is entertainment. A librarian is a profession whose job is to provide and present information to its users. how is the level of readiness of higher education librarians in the era of disruption including what factors affect the readiness of librarians and how librarians adjust to the era of disruption 4.0. In this study using the method of Quantitative Research. This method was chosen by the author because the author wanted to know the level of readiness to implement the development of information technology with the basis or tools on the model developed by Mutula and Brakel. E Readiness, shows a value of 3.393. The value can mean “Ready”. This average calculation is obtained from the average results for each sub-indicator which then becomes the value for each segment or indicator and then is averaged again to find the value of readiness information for the era of disruption 4.0.

Pada era disrupsi revolusi industri 4.0 seperti saat ini, hampir tidak ada kesulitan dalam hal pemenuhan kebutuhan informasi. Baik informasi yang bersifat pendidikan ataupun informasi yang bersifat hiburan. Pustakawan salah satu profesi yang bertugas menyediakan dan menyajikan informasi bagi penggunanya. bagaimana tingkat kesiapan pustakawan peguruan tinggi dalam era disrupsi termasuk faktor apa saja yang mempengaruhi kesiapan dari pustakawan dan bagaimana pustakawan dalam menyesuaikan diri dalam era disrupsi 4.0. Dalam penelitian ini menggunakan metode Quantitative Research. Metode ini dipilih penulis karena penulis ingin mengetahui tingkat kesiapan implementasi perkembangan teknologi informasi dengan dasar atau tool pada model yang dikembangkan mutula dan brakel. E Readiness, menunjukan nilai 3,393. Nilai tersebut dapat berarti “Siap”. Perhitungan rata – rata ini didapatkan dari hasil rata – rata pada setiap sub indikator yang kemudian menjadi nilai pada setiap segmen atau indikator dan kemudian di rata – rata kembali untuk menemukan nilai keterangan kesiapan terhadap era disrupsi 4.0.
Landscape of Prognostic m6A RNA Methylation Regulators in Hepatocellular Carcinoma to Aid Immunotherapy
Authors: Xu Qianhui , Xu Hao , Deng Rongshan , Li Nanjun , Mu Ruiqi , Qi Zhixuan , Shen Yunuo , Wang Zijie , Wen Jingchao , Zhao Jiaxin , Weng Di , Huang Wen 
Published: August 2021

Background:Hepatocellular carcinoma (HCC) is the sixth most common malignancy with a high mortality worldwide. N6-methyladenosine (m6A) may participate extensively in tumor progression.Methods:To reveal the landscape of tumor immune microenvironment (TIME), ESTIMATE analysis, ssGSEA algorithm, and the CIBERSORT method were used. Taking advantage of consensus clustering, two different HCC categories were screened. We analyzed the correlation of clustering results with TIME and immunotherapy. Then, we yielded a risk signature by systematical bioinformatics analyses. Immunophenoscore (IPS) was implemented to estimate the immunotherapeutic significance of risk signature.Results:The m6A-based clusters were significantly correlated with overall survival (OS), immune score, immunological signature, immune infiltrating, and ICB-associated genes. Risk signature possessed robust prognostic validity and significantly correlated with TIME context. IPS was employed as a surrogate of immunotherapeutic outcome, and patients with low-risk scores showed significantly higher immunophenoscores.Conclusion:Collectively, m6A-based clustering subtype and signature was a robust prognostic indicator and correlated with TIME and immunotherapy, providing novel insight into antitumor management and prognostic prediction in HCC.
Morphomolecular Characterization of Serum Nanovesicles From Microbiomes Differentiates Stable and Infarcted Atherosclerotic Patients
Authors: Moreno Camila Rodrigues , Ramires José Antonio Franchini , Lotufo Paulo Andrade , Soeiro Alexandre Matos , Oliveira Luanda Mara da Silva , Ikegami Renata Nishiyama , Kawakami Joyce Tiyeko , Pereira Jaqueline de Jesus , Reis Marcia Martins , Higuchi Maria de Lourdes 
Published: August 2021

Microbial communities are considered decisive for maintaining a healthy situation or for determining diseases. Acute myocardial infarction (AMI) is an important complication of atherosclerosis caused by the rupture of atheroma plaques containing proinflammatory cytokines, reactive oxygen species, oxidized low-density lipoproteins (oxLDL), damaged proteins, lipids, and DNA, a microenvironment compatible with a pathogenic microbial community. Previously, we found that archaeal DNA-positive infectious microvesicles (iMVs) were detected in vulnerable plaques and in the sera of Chagas disease patients with heart failure. Now, we characterize and quantify the levels of serum microbiome extracellular vesicles through their size and content using morphomolecular techniques to differentiate clinical outcomes in coronary artery disease (CAD). We detected increased numbers of large iMVs (0.8–1.34 nm) with highly negative surface charge that were positive for archaeal DNA, Mycoplasma pneumoniae antigens and MMP9 in the sera of severe AMI patients, strongly favoring our hypothesis that pathogenic archaea may play a role in the worst outcomes of atherosclerosis. The highest numbers of EVs &lt;100 nm (exosomes) and MVs from 100 to 200 nm in the stable atherosclerotic and control healthy groups compared with the AMI groups were indicative that these EVs are protective, entrapping and degrading infectious antigens and active MMP9 and protect against the development of plaque rupture.Conclusion: A microbiome with pathogenic archaea is associated with high numbers of serum iMVs in AMI with the worst prognosis. This pioneering work demonstrates that the morphomolecular characterization and quantification of iEVs in serum may constitute a promising serum prognostic biomarker in CAD.
Precision Therapy for a Chinese Family With Maturity-Onset Diabetes of the Young
Authors: Li Juyi , Shu Meng , Wang Xiufang , Deng Aiping , Wen Chong , Wang Juanjuan , Jin Si , Zhang Hongmei 
Published: August 2021

ObjectiveTo determine the pathogenic gene and explore the clinical characteristics of maturity-onset diabetes of the young type 2 (MODY2) pedigree caused by a mutation in the glucokinase (GCK) gene.MethodsUsing whole-exome sequencing (WES), the pathogenic gene was detected in the proband—a 20-year-old young man who was accidentally found with hyperglycemia, no ketosis tendency, and a family history of diabetes. The family members of the proband were examined. In addition, relevant clinical data were obtained and genomic DNA from peripheral blood was obtained. Pathologic variants of the candidate were verified by Sanger sequencing technology, and cosegregation tests were conducted among other family members and non-related healthy controls. After adjusting the treatment plan based on the results of genetic testing, changes in biochemical parameters, such as blood glucose levels and HAblc levels were determined.ResultsIn the GCK gene (NM_000162) in exon 9, a heterozygous missense mutation c.1160C &gt; T (p.Ala387Val) was found in the proband, his father, uncle, and grandmother. Thus mutation, which was found to co-segregate with diabetes, was the first discovery of such a mutation in the Asian population. After stopping hypoglycemic drug treatment, good glycemic control was achieved with diet and exercise therapy.ConclusionGCK gene mutation c.1160C &gt; T (p.Ala387Val) is the pathogenic gene in the GCK-MODY pedigree. Formulating an optimized and personalized treatment strategy can reduce unnecessary excessive medical treatment and adverse drug reactions, and maintain a good HbA1c compliance rate
Simulated Experiment on Wind Erosion Resistance of Salix Residual in the Agro-Pastoral Ecotone
Authors: Li Qiang , Kang Furen , Zhang Zheng , Ma Chunyan , Nan Weige 
Published: August 2021

Plant residual is of great importance in retarding soil wind erosion in the agro-pastoral ecotone. However, few studies have determined the effects of sand plant residual on wind erosion resistance. Based on field surveys, the influences of Salix residual biomass of 200, 400, 600, and 800 g m−2, soil incorporated with a residual thickness of 0.5, 1.0, and 2.0 cm, and typical proportion of residual branches and leaves (2:1, 1:1, and 1:2) on wind erosion resistance were investigated using a simulated wind tunnel. The results showed the following: 1) The soil loss amount ranged from 1.56 to 40.8 kg m−2 as Salix residual biomass decreased from 800 to 0 g m−2, with a critical residual biomass value of 400 g m−2. 2) As the thickness of soil-incorporated residual increased, the soil loss amount reduced rapidly, especially for 0–9 cm above the surface accounting for 84.6% of the total. 3) Salix branch residual is more important in resisting soil wind erosion as compared with its leaves. This kind of study may provide theoretical explanations for the optimal reconstruction of sandy vegetation in the northern wind-sand regions.