bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Ground Microtremor Data in Advanced Rockfall Early Warning Systems and Predicting Spatiotemporal Characteristics of Rockfall Hazards
Authors: Yang Yi-Rong , Lee Tzu-Tung , Wang Tai-Tien 
Published: October 2021

Abstract
Identifying cliffs that are prone to fall and providing a sufficient lead time for rockfall warning are crucial steps in disaster risk reduction and preventive maintenance work, especially that led by local governments. However, existing rockfall warning systems provide uncertain rockfall location forecasting and short warning times because the deformation and cracking of unstable slopes are not sufficiently detected by sensors before the rock collapses. Here, we introduce ground microtremor signals for early rockfall forecasting and demonstrate that microtremor characteristics can be used to detect unstable rock wedges on slopes, quantitatively describe the stability of slopes and lengthen the lead time for rockfall warning. We show that the change in the energy of ground microtremors can be an early precursor of rockfall and that the signal frequency decreases with slope instability. This finding indicates that ground microtremor signals are remarkably sensitive to slope stability. We conclude that microtremor characteristics can be used as an appropriate slope stability index for early rockfall warning systems and predicting the spatiotemporal characteristics of rockfall hazards. This early warning method has the advantages of providing a long lead time and on-demand monitoring, while increasing slope stability accessibility and prefailure location detectability.
Staff Attitudes Towards Electronic Data Collection for a National Take-Home Naloxone Program
Authors: Ericson Øystein Bruun , Eide Desiree , Lobmaier Philipp , Clausen Thomas 
Published: October 2021

Abstract
Background

During the scaling-up of a national Norwegian take-home naloxone (THN) program, data collection methods shifted from paper-based to electronic. The aim of this study was to explore staff attitudes and preferences towards the shift in data collection.
Methods

In January-February 2020, a survey was sent out via email to personnel involved with the THN program (n=200). The survey included 17 questions, and covered staff demographics, experiences distributing THN, attitudes towards data collection (both paper and electronically), and an open response section. Descriptive statistics were performed for the survey results. The open response section was recorded from each questionnaire and was coded into major themes by the authors.
Main findings

In total, 122 staff completed the survey. Of these, 62% had experience with both electronic and paper-based forms, and there was a near unanimous preference towards electronic data collection over paper-based forms. From the free-text responses, staff found the electronic form to be a useful tool for conversation and overdose prevention education, and that the electronic form was easier to manage than the paper forms.
Conclusion

The shift towards electronic data collection was necessary for the feasibility of the Norwegian national THN program. This study found that staff not only tolerated the shift, but in most cases preferred this organizational change.
Radiologic Analysis of Causes of Early Recurrence after Percutaneous Endoscopic Transforaminal Discectomy
Authors: Li Zepeng , Liu Lulu , Liu Hao , Tan Jinghua , Li Xuelin , Xu Zhun , Ouyang Zhihua , Wang Cheng , Yan Yiguo , Xue Jingbo 
Published: October 2021

Abstract
Objective: To retrospectively analyze causes of, and factors influencing, early recurrence after percutaneous endoscopic transforaminal discectomy (PETD) used to treat lumbar-disc herniation. Methods: We included 285 patients with single-segment lumbar-disc herniation, treated using PETD from January 2017 to December 2019 in the First Affiliated Hospital of the University of South China. Patients were classified into early recurrence and non-early recurrence groups based on clinical symptoms and MRI reexamination. Differences in disc-height index (DHI), sagittal range of motion (sROM), base-width of intervertebral disc degeneration, and postoperative intervertebral annulus-fibrosus tear size were compared using independent-sample t test. Differences in degree of intervertebral disc degeneration and herniation sites were analyzed using rank-sum and chi-square tests. Logistic regression was used for multivariate analysis of factors associated with early recurrence after PETD. Results: Two hundred and eighty five patients completed surgery and underwent clinical follow-up. Mean follow-up duration was 15.5 months (12–24 months). During follow-up, 19 patients relapsed within 6 months post-surgery. Early recurrence rate was 6.7%, and mean recurrence duration was 73.4 days (3–168 days). Differences in DHI, base-width, postoperative annulus-fibrosus tear size, degree of intervertebral disc degeneration, and herniation sites between early recurrence and non-early recurrence groups were statistically significant (P<0.05). Herniation site and base-width of herniation were significantly correlated with early recurrence after PETD. Conclusions: DHI, postoperative annulus-fibrosus tear size, and degree of intervertebral disc degeneration were associated with early recurrence after PETD. Increased base-width of herniation was a risk factor for early recurrence after PETD. Central-herniation patients with were more prone to postoperative early recurrence than paracentral-herniation patients.
Novel Chalcone-Derived Pyrazoles as Potential Therapeutic Agents for the Treatment of Non-small Cell Lung Cancer
Authors: Maciejewska Natalia , Olszewski Mateusz , Jurasz Jakub , Serocki Marcin , Dzierzynska Maria , Cekala Katarzyna , Wieczerzak Ewa , Baginski Maciej 
Published: October 2021

Abstract
Lung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential anticancer agents for non-small cell lung cancer A-549, H226, and H460 cell lines. Most of the compounds (PCH-1) efficiently inhibited the growth of all the tested cancer cell lines at micromolar concentrations. One of the most active compounds was further evaluated for its effect on cell cycle distribution, apoptosis, migration, epithelial-mesenchymal transition, and oxidative stress. Furthermore, studies on the mechanism of action revealed that PCH-1 disrupts microtubule assembly, leading to cancer cell death. Molecular modeling studies confirmed the potent interaction of PCH-1 with the colchicine binding site on tubulin. Overall, this study provides novel opportunities to identify anticancer agents in the pyrazole series.
Emergency Treatment on Gartland Type III Pediatric Supracondylar Humeral Fractures: a Retrospective Analysis of Therapeutic Consequences of Surgery
Authors: Wang Qian , Wang Yu , Zhao Jingxin 
Published: October 2021

Abstract
Objective: The objective of this analysis was to investigate the effect of emergency treatment by simple reduction within 8 h of injury for Gartland type III pediatric supracondylar humeral fractures.Methods: One hundred twenty children with Gartland type III supracondylar humeral fractures were studied. All 120 patients had extension-type fractures and each was classified into one of two groups as follows: group A (n = 90), treated by closed reduction; group B (n = 30), treated by open reduction. Both groups underwent Kirschner wire internal fixation within 1 to 5 d after reduction. Information on the emergency treatments within 8 h of the fracture and the duration of the subsequent surgeries was collected and compared between the two groups. Results: There was no significant difference between the two patient groups in terms of the demographic parameters. Compared to non-emergency surgery, emergency surgery required shorter operation time and fewer complications (P<0.05). Nevertheless, the fracture healing time was significantly less (P＜0.05), and Flynn scores were higher in the closed reduction group compared to the open reduction group (P<0.05).Sixty-six of the 90 patients in group A received emergency treatment with an average subsequent surgery duration of 40 min. The remaining 24 patients did not receive emergency treatment and had an average surgery duration of 65 min. Of the 30 patients in group B, four received emergency treatment with a subsequent average surgery duration of 70 min. The remaining 26 patients did not receive emergency treatment and had an average surgery duration of 91 min. Conclusion: Emergency treatment by simple reduction within 8 h of fracture was important for subsequent surgical procedures and duration. Lack of this treatment could increase the risks during open reduction. Emergency treatment within 8 h of fracture could increase the healing rate and reduce the duration of the subsequent surgery.
The Flow of the Berry Curvature Vector Field
Authors: Stejskal Ondřej , Veis Martin , Hamrle Jaroslav 
Published: October 2021

Abstract
The concept of Berry phase and Berry curvature has become ubiquitous in solid state physics as it relates to variety of phenomena, such as topological insulators, polarization, and various Hall effects. It is well known that large Berry curvatures arise from close proximity of hybridiz-ing bands, however, the vectorial nature of the Berry curvature is not utilized in current research. On bulk bcc Fe, we demonstrate the flow of the Berry curvature vector field which features not only monopoles but also higher dimensional structures with its own topological features. They can provide a novel unique view on the electronic structure in all three dimensions. This knowledge is also used to quantify particular contributions to the intrinsic anomalous Hall effect in a simple analytical form.
H3K27M-mutant Diffuse Midline Gliomas should be Further Molecularly Stratified: An Integrated Analysis of 669 Patients
Authors: Vuong Huy Gia , Le Hieu Trong , Ngo Tam N.M. , Fung Kar-Ming , Battiste James D. , McNall-Knapp Rene , Dunn Ian F. 
Published: October 2021

Abstract
Introduction: H3K27M-mutated diffuse midline gliomas (H3-DMGs) are aggressive tumors with a fatal outcome. This study integrating individual patient data (IPD) from published studies aimed to investigate the prognostic impact of different genetic alterations on survival of these patients.Methods: We accessed PubMed and Web of Science to search for relevant articles. Studies were included if they have available data of follow-up and additional molecular investigation of H3-DMGs. For survival analysis, Kaplan-Meier analysis and Cox regression models were utilized, and corresponding hazard ratios (HR) and 95% confidence intervals (CI) were computed to analyze the impact of genetic events on overall survival (OS).Result: We included 30 studies with 669 H3-DMGs. TP53 mutations were the most common second alteration among these neoplasms. In univariate Cox regression model, TP53 mutation was an indicator of shortened survival (HR = 1.446; 95% CI = 1.143-1.829) whereas ACVR1 (HR = 0.712; 95% CI = 0.518-0.976) and FGFR1 mutations (HR = 0.408; 95% CI = 0.208-0.799) conferred prolonged survival. In addition, ATRX loss was also associated with a better OS (HR = 0.620; 95% CI = 0.386-0.996). Adjusted for age, gender, tumor location, and the extent of resection, the presence of TP53 mutations, the absence of ACVR1 or FGFR1 mutations remained significantly poor prognostic factors.Conclusions: We outlined the prognostic importance of additional genetic alterations in H3-DMGs and recommended that these neoplasms should be further molecularly segregated. It could help neuro-oncologists better evaluate the risk stratification of patients and consider pertinent treatments.
Effect of Soluble Amyloid Precursor Protein-alpha on Adult Hippocampal Neurogenesis in a Mouse Model of Alzheimer’s Disease
Authors: Ohline Shane M. , Chan Connie , Schoderboeck Lucia , Wicky Hollie E. , Tate Warren P. , Hughes Stephanie M. , Abraham Wickliffe 
Published: October 2021

Abstract
Soluble amyloid precursor protein-alpha (sAPPα) is a regulator of neuronal and memory mechanisms, while also having neurogenic and neuroprotective effects in the brain. As adult hippocampal neurogenesis is impaired in Alzheimer’s disease, we tested the hypothesis that sAPPα delivery would rescue adult hippocampal neurogenesis in an APP/PS1 mouse model of Alzheimer’s disease. An adeno-associated virus-9 (AAV9) encoding murine sAPPα was injected into the hippocampus of 8 month-old wild-type and APP/PS1 mice, and later two different thymidine analogues (XdU) were systemically injected to label adult-born cells at different time points after viral transduction. The proliferation of adult-born cells, cell survival after eight weeks, and cell differentiation into either neurons or astrocytes was studied. Proliferation was impaired in APP/PS1 mice but was restored to wild-type levels by viral expression of sAPPα. In contrast, sAPPα overexpression failed to rescue the survival of XdU+-labelled cells that was impaired in APP/PS1 mice, although it did cause a significant increase in the area density of astrocytes in the granule cell layer across both genotypes. Finally, viral expression of sAPPα reduced amyloid-beta plaque load in APP/PS1 mice in the dentate gyrus and somatosensory cortex. These data add further evidence that increased levels of sAPPα could be therapeutic for the cognitive decline in AD, in part through restoration of the proliferation of neural progenitor cells in adults.
Methanolic extract of Moringa oleifera leaves induces Cell cycle arrest and downregulates Mitochondrial membrane potential in Dalton's Lymphoma cells.
Authors: Kumar Sandeep , Shukla Alok , Verma Praveen Kumar , Singh Rishi kant , Kumar Naveen , Patel Anand kumar , Yadav Lokesh , Kumar Sanjay , Acharya Arbind 
Published: October 2021

Abstract
Cancer is a group of diseases characterised by abnormal and undifferentiated cell growth that has the potential to spread to other parts of the body. It is the world's second leading cause of death and morbidity. According to the GLOBOCAN 2020 report, out of 19.3 million new cancer cases and 10 million deaths reported, 544352 new cases and 259793 deaths occurred by non-Hodgkin lymphoma (NHLs). Although, numerous therapeutic approaches like, surgery, radiotherapy, chemotherapy and immunotherapy have been developed to treat cancer, limited success has been achieved, possibly due to severe side effects associated with the drugs used during chemotherapy. Therefore, deciphering the novel compound with least side effects and highly potent against cancer is urgently required. In the present study we used leaf extract of M. oleifera, well-known for its anti-cancer efficacy against different cancer cells, however, its effect on Dalton’s lymphoma, a type of spontaneously occurring T cell lymphoma originated in the thymus of DBA mice is seriously lacking. Therefore, present study was aimed to analyze the therapeutic efficacy of M. oleifera against DL cells. Our results show that leaf extract of M. oleifera (MOML) significantly induces morphological changes in DL cells followed by chromatin condensation, nuclear fragmentation, and ROS generation. We also found significant changes in mitochondrial membrane potential (ΔΨm) in a dose dependent manner. Furthermore, apoptosis of DL cells induced by cell cycle arrest at G2/M and S phase suggested that MOML could be used to treat NHL effectively
Please Let Science Talk: Presidential Sentiment and the Public’s Risk Perception in the Era of COVID-19
Authors: Guo Jie , Yang Junhong , Zeng Yeqin , Zhu Shulei 
Published: October 2021

Abstract
We examine whether and to what extent the presidential COVID-19 sentiment (PCS), constructed based on the former President Trump’s tweets, has influenced the public’s risk perception regarding COVID-19. We find that during the COVID-19 pandemic, PCS is negatively associated with social distancing behaviour in the Republican counties but is positively associated with social distancing behaviour in the Democratic counties. Our finding supports the view that individuals’ risk perception is influenced by the information they receive from politicians through social media, with the impact exhibiting as variations with respect to the individuals’ position on the political spectrum.
Case Report: Congenital nasal pyriform aperture stenosis with holoprosencephaly: Diagnosis and surgical management
Authors: Yilala Melcol Hailu , Dibaba Dawit Kibebew , Gebrekidan Messay , Tilahun Dessalegn 
Published: October 2021

Abstract
Congenital nasal pyriform aperture stenosis (CNPAS) is a rare cause of neonatal nasal obstruction that clinically mimics choanal atresia. It occurs as a result of abnormal development of primary palate and maxilla, either in isolation or in association with other anomalies. Differentiation between CNSPAS and choanal atresia is critical as management approachers are quite different from one another. Diagnosis can be made clinically and with characteristics CT findings. Management options include both conservative and surgical approaches depending on the patient’s initial condition. Here is reported a case of 33 days infant who was admitted to our NICU with a working diagnosis of CNPAS after she presented with two days of fast breathing and failure to suckle, managed surgically and discharged improved.
Anais I JASBI - I Jornada Acadêmica de Saúde Bucal Inclusiva UFPR
Authors: Mendes Pupo Yasmine , Sarot João Rodrigo , De Lima Heliton Gustavo , Lopes Jaqueline do Carmo Machado 
Published: October 2021

Caro(a) Leitor(a),
A Jornada Acadêmica de Saúde Bucal Inclusiva (JASBI) é um evento científico realizado pelo projeto de extensão Saúde Bucal Inclusiva da UFPR com o objetivo proporcionar conhecimento científico diante do atendimento odontológico e multiprofissional da pessoa com deficiência, parcela muitas vezes desassistida da população, preparando os futuros e/ou profissionais da área para tratamentos de qualidade a estes pacientes. Os principais tópicos abordados no evento foram métodos minimamente invasivos de controle da doença cárie; sedação inalatória com óxido nitroso e oxigênio como opção no atendimento de pessoas com deficiência; reconhecimento do papel do fonoaudiólogo na atuação multiprofissional com o cirurgião-dentista no atendimento de pessoas com deficiência; alterações bucais presentes na cavidade bucal de pacientes idosos; percepção sobre as técnicas de manejo e importância da saúde bucal preventiva para a qualidade de vida de pessoas com deficiência; atuação do cirurgião-dentista bucomaxilofacial no tratamento de fissuras lábio palatinas. Além disso, parte do evento foi direcionado a apresentação e discussão de trabalhos científicos com mediação por professores da área de atendimento das pessoas com deficiência (PDs).
A coordenadora do projeto de extensão Saúde Bucal Inclusiva Profª. Drª. Yasmine Mendes Pupo e presidente do evento, reuniu acadêmicos de Odontologia da Universidade Federal do Paraná para compor uma comissão organizadora totalizando 22 colaboradores, internos do projeto e externos. No total o evento contou com 1200 inscritos de diversas Universidades do Brasil e 130 submissões de trabalhos científicos. O evento favoreceu a maior visibilidade das ações do projeto de extensão vinculado aumentando consideravelmente o número de seguidores no Instagram (sbi_ufpr).
A I JASBI, transmitida ao vivo pelo Youtube, aconteceu nos dias 19, 20 e 21 de maio de 2021, com temas de extrema relevância para o atendimento odontológico de PDs, o que culminou em 3700 visualizações das palestras durante a semana do evento. No dia 21, período da manhã e tarde, foram realizadas as apresentações de trabalhos selecionados de forma síncrona e os demais foram disponibilizados em playlist no Youtube de forma assíncrona. Os resumos referentes as apresentações síncronas e assíncronas encontram-se no presente anais, assim como, os trabalhos premiados no transcorrer do evento.
Comissão Organizadora
I JASBI - UFPR (Universidade Federal do Paraná) 2021
Evaluation of Cellulolytic Endo-1,4-B-D-Glucanase Activity in the Digestive Fluid of Adult Phytophagous Beetle Hoplasoma unicolor
Authors: Mohammad Mosleh Uddin  , Suzana Afrin Lima  , Tanim Jabid Hossain  , Newton Kar  , Yeasmin Zahan  , Babamale AbdulKareem Olarewaju  
Published: October 2021

Insects of the taxonomic order Coleoptera are recognised for considerable cellulolytic activity in their digestive fluid. The cellulolytic activity of the gut fluid in Hoplasoma unicolor, a member of Coleoptera, however, remains unexplored. In this study, we, for the first time, report the qualitative and quantitative analysis of cellulolytic activity in the digestive fluid of this insect. The cellulolytic endo-1,4-?-D-glucanase activity was confirmed in the supernatant of the insect’s digestive fluid by agar plate assay using carboxymethyl cellulose as the substrate. To determine the optimum pH, enzyme activity was further assessed in an acidic pH range of 5 to 6, and the highest activity was observed at pH 5.3. For quantitative analysis, endoglucanase activity was measured using 3,5-dinitrosalicylic acid method which revealed that the specific activity of the gut sample was 0.69 (±0.01) units per mg of protein. For further characterisation of the cellulases in the sample, SDS-PAGE and zymogram analysis were carried out. Two active cellulolytic bands were detected on the zymogram suggesting the presence of two distinct endoglucanases which completely disappeared upon heating the sample at 55°C. Our study, therefore, highlights prospect of the gut fluid of H. unicolor as an important source of cellulase enzymes that merits further investigations into their extensive characterisation for potential industrial applications.
The hidden WASH needs of perimenopausal women
Authors: Bhakta Amita , Esseku Harold , Esseku Yvonne , Fisher Julie , Reed Brian 
Published: October 2021

Abstract
Meeting the needs of an ageing population, particularly in the global South, is increasingly an issue for WASH service provision. An ageing-related issue for women, warranting specific attention from the WASH sector, is the perimenopause, but this is often not discussed publicly. Drawing on data from the UK and Ghana, this paper provides recommendations for meeting the additional WASH needs of women as they experience the perimenopause (the transition period to menopause). Finding these ‘hidden’ needs involved a UK-based phenomenological review and mixed feminist methods in two low-income urban communities in Accra and Kumasi, Ghana. The hidden WASH needs of perimenopausal women included understanding the perimenopause, menstrual hygiene management, urine incontinence management, bathing, and laundry. Community awareness, engagement and empowerment, and ensuring good perimenopausal health can begin to address these needs. Infrastructural measures for perimenopausal women include a continuous water supply, user-friendly bathing and laundry infrastructure, and gender-sensitive, accessible toilets with discrete sanitary disposal bins. High-absorbency sanitary products are important for managing heavy menstruation. A better understanding of the needs of perimenopausal women and training on how to meet these would benefit the WASH sector in ensuring that perimenopausal women are not left behind in efforts to meet the Sustainable Development Goals.