bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bedtimes, bedtime routines, and children’s sleep across the first 2 years of life
Authors: Fiese Barbara H , Cai Tianying , Sutter Carolyn , Bost Kelly K 
Published: February 2021

AbstractStudy ObjectivesThe first objective of this study was to determine whether establishing bedtime routines in the first year of life predicts better sleep outcomes (i.e. longer sleep duration, less nighttime waking, earlier bedtime, shorter sleep latency, fewer sleep problems) across the first 2 years of life. The second objective was to determine whether specific adaptive bedtime activities (e.g. book reading) were associated with sleep outcomes. The third objective was to describe changes in adaptive bedtime activities (hug/kiss caregiver, say goodnight to family) across the first 2 years of life.MethodsParents of 468 children from the STRONG Kids 2 birth cohort were surveyed about bedtime and bedtime routines, their child’s sleep duration, nighttime waking, sleep latency, and sleep problems at 3, 12, 18, and 24 months of age.ResultsCross-lagged panel models revealed partial evidence for reciprocal associations between bedtime routine consistency and adaptive bedtime activities and better sleep outcomes over time. Specifically, more bedtime routine consistency predicted less nighttime waking and sleep problems, and more bedtime adaptive activities predicted longer sleep duration and fewer sleep problems.DiscussionThe findings are discussed from a developmental perspective to highlight how consistency of bedtime routines established as early as 3 months of age may affect sleep outcomes and that the adaptive activities associated with these routines may increase in frequency over the first 2 years of life.
More than Recruitment: How Social Ties Support Protest Participation
Authors: Walgrave Stefaan , Wouters Ruud 
Published: February 2021

Abstract
Social movement scholars have frequently pointed to individuals’ personal networks to explain protest participation. While the recruitment function of micro networks has been explored in depth, the support effect of networks has received only scant attention. The study explores how and to what extent social support and social constraints in people’s personal networks explain differential protest participation. Three dimensions of support are distinguished: the politicization of a person’s network, the political agreement about the protest topic within a person’s network, and the social approval of protest participation within a person’s network. Drawing on panel survey data (N=1,684) of a large protest in Belgium including both participants and non-participants, we test whether the support effects of networks play a role on top of the recruitment effect. We find evidence that two functions of social networks (politicization and social approval) affect protest participation. Additionally, we find differences in support-effects across types of social ties. Co-members of an organization exert influence on protest participation across a variety of support functions. The most intimate ties prospective participants have (partners), in contrast, matter only in so far as they approve of participation.
Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats
Authors: Salberg Sabrina , Yamakawa Glenn R , Griep Yannick , Bain Jesse , Beveridge Jaimie K , Sun Mujun , McDonald Stuart J , Shultz Sandy R , Brady Rhys D , Wright David K , Noel Melanie , Mychasiuk Richelle 
Published: February 2021

Abstract
Although adverse early experiences prime individuals to be at increased risk for chronic pain, little research has examined the trauma–pain relationship in early life or the underlying mechanisms that drive pathology over time. Given that early experiences can potentiate the nociceptive response, this study aimed to examine the effects of a high-fat, high-sugar (HFHS) diet and early life stress (maternal separation [MS]) on pain outcomes in male and female adolescent rats. Half of the rats also underwent a plantar-incision surgery to investigate how the pain system responded to a mildly painful stimuli in adolescence. Compared with controls, animals that were on the HFHS diet, experienced MS, or had exposure to both, exhibited increased anxiety-like behavior and altered thermal and mechanical nociception at baseline and following the surgery. Advanced magnetic resonance imaging demonstrated that the HFHS diet and MS altered the maturation of the brain, leading to changes in brain volume and diffusivity within the anterior cingulate, amygdala, corpus callosum, nucleus accumbens, and thalamus, while also modifying the integrity of the corticospinal tracts. The effects of MS and HFHS diet were often cumulative, producing exacerbated pain sensitivity and increased neurobiological change. As early experiences are modifiable, understanding their role in pain may provide targets for early intervention/prevention.
Integrative taxonomy of calcareous sponges (Porifera: Calcarea) from Réunion Island, Indian Ocean
Authors: Klautau Michelle , Lopes Matheus Vieira , Tavares Gabriela , Pérez Thierry 
Published: February 2021

AbstractThe Western Indian Ocean Province is reckoned for its rich marine diversity; however, sponges of the Mascarene Islands ecoregion are still poorly known. In La Réunion, only three species of class Calcarea have been registered. Hence, calcareous sponges were searched in seven sites representing various habitats of the Western coast of La Réunion, but found in only three of them. A total of 23 sponge samples was identified using morphological and molecular taxonomy. This sampling represents 11 species, all new records for the region, and seven of them are new to science: Ascandra mascarenica sp. nov., A. oceanusvitae sp. nov., Janusya indica gen. et sp. nov., Leucascus tenuispinae sp. nov., Lelapiella tertia sp. nov., Soleneiscus intermedius sp. nov. and Leucandra ornata sp. nov.; and a new genus, Janusya gen. nov.. Based on results from this and from previous studies, we propose the synonymization of the order Murrayonida with Clathrinida. A very low sampling effort has thus increased the number of calcareous sponge species from the Mascarenes Islands ecoregion by 69 % and from La Réunion by 367%.
Gender Bias: Another Rising Curve to Flatten?
Authors: Lewiss Resa E. , Jagsi Reshma 
Published: February 2021

The COVID-19 pandemic and the upheaval it is causing may be leading to novel manifestations of the well-established mechanisms by which women have been marginalized in professional roles, robbing the field of the increased collective intelligence that exists when diverse perspectives are embraced. Unconscious bias, gendered expectations, and overt hostility minimize the contributions of women in academic medicine to the detriment of all. The current environment of heightened stress and new socially distant forms of communication may be exacerbating these well-recognized obstacles to women contributing to the field. Of note, none of these actions requires ill intent; all they require is the activation of unconscious biases and almost instinctive preferences and behaviors that favor the comfortable and familiar leadership of men in a time of extreme stress.
The authors argue that it is time to investigate the frequency of behaviors that limit both the recognition and the very exercise of women’s leadership during this pandemic, which is unprecedented but nevertheless may recur in the future. Leaders in health care must pay attention to equity, diversity, and inclusion given increases in undermining and harassing behaviors toward women during this crisis. The longer-term consequences of marginalizing women may hamper efforts to combat the next pandemic, so the time to flatten the rising gender bias curve in academic medicine is now.
Optimizing Surgeon Well-Being
Authors: Vitous C. Ann , Dinh Duyhoang Q. , Jafri Sara M. , Bennett Olivia M. , MacEachern Mark , Suwanabol Pasithorn A. 
Published: February 2021

Objective:
Through a systematic review and mixed-methods meta-synthesis of the existing literature on surgeon well-being, we sought to identify the specific elements of surgeon well-being, examine factors associated with suboptimal well-being, and highlight opportunities to promote well-being.

Background:
Suboptimal surgeon well-being has lasting and substantial impacts to the individual surgeon, patients, and to society as a whole. However, most of the existing literature focuses on only 1 aspect of well-being—burnout. While undoubtedly a crucial component of overall well-being, the mere absence of burnout does not fully consider the complexities of being a surgeon.

Methods:
We performed a literature search within Ovid Medline, Elsevier Excerpta Medica dataBASE, EBSCOhost Cumulative Index to Nursing and Allied Health Literature, and Clarivate Web of Science from inception to May 7, 2020, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies with primary data examining surgeon well-being were included. Using a predetermined instrument, data were abstracted from each study and compared using thematic analysis.

Results:
A total of 5369 abstracts were identified and screened, with 184 full articles (172 quantitative, 3 qualitative, 9 mixed methods) selected for analysis. Among these, 91 articles measured burnout, 82 examined career satisfaction, 95 examined work-related stressors, 44 explored relationships and families, and 85 assessed emotional and physical health. Thematic analysis revealed 4 themes: professional components, personal components, work-life balance, and impacts to well-being.

Conclusions:
Surgeon well-being is complex and multifaceted. This nuanced examination of surgeon well-being highlights the critical need to develop and provide more long-term support to surgeons—with interventions being tailored based on individual, institutional, and systemic factors.
Endovascular Hepatic Artery Stents in the Modern Management of Postpancreatectomy Hemorrhage
Authors: Finch Louise M. , Baltatzis Minas , Byott Sam , Ganapathy Anantha-Krishnan , Kakani Nirmal , Lake Edward , Cadwallader Rosemary , Hazar Can , Seriki Dare , Butterfield Stephen , Jegatheeswaran Santhalingam , Jamdar Saurabh , de Liguori Carino Nicola , Siriwardena Ajith K. 
Published: February 2021

Background:
Postoperative hemorrhage is a potentially lethal complication of pancreatoduodenectomy. This study reports on the use of endovascular hepatic artery stents in the management of postpancreatectomy hemorrhage.

Methods:
This is a retrospective analysis of a prospectively maintained, consecutive dataset of 440 patients undergoing pancreatoduodenectomy over 68 months. Data are presented on bleeding events and outcomes, and contextualized by the clinical course of the denominator population. International Study Group of Pancreatic Surgery terminology was used to define postpancreatectomy hemorrhage.

Results:
Sixty-seven (15%) had postoperative hemorrhage. Fifty (75%) were male and this gender difference was significant (P = 0.001; 2 proportions test). Postoperative pancreatic fistulas were more frequent in the postoperative hemorrhage group (P = 0.029; 2 proportions test). The median (interquartile range [IQR]) delay between surgery and postoperative hemorrhage was 5 days (2–14 days). Twenty-six (39%) required intervention comprising reoperation alone in 12, embolization alone in 5, and endovascular hepatic artery stent deployment in 5. Four further patients underwent more than 1 intervention with 2 of these having stents. Endovascular stent placement achieved initial hemostasis in 5 of 7 (72%). Follow-up was for a median (IQR) of 199 days (145–400 days) poststent placement. In 2 patients, the stent remained patent at last follow-up. The remaining 5 stents occluded with a median (IQR) period of proven patency of 10 days (8–22 days).

Conclusions:
This study shows that in the specific setting of postpancreatoduodenectomy hemorrhage with either a short remnant gastroduodenal artery bleed or a direct bleed from the hepatic artery, where embolization risks occlusion with compromise of liver arterial inflow, endovascular hepatic artery stent is an important hemostatic option but is associated with a high risk of subsequent graft occlusion.
Impact of Preoperative Malnutrition on Postoperative Long-Term Outcomes of Patients With Pancreatic Head Cancer
Authors: Lee Boram , Han Ho-Seong , Yoon Yoo-Seok 
Published: February 2021

Objective:
To evaluate the association between preoperative malnutrition and long-term outcomes in patients with pancreatic head cancer who underwent curative pancreatoduodenectomy (PD).

Methods:
From 2004 to 2018, 228 consecutive patients who underwent curative PD for pancreatic ductal adenocarcinoma were included. Preoperative malnutrition was defined by the Global Leadership Initiative in Malnutrition criteria. It is based on both phenotypic criteria (weight loss, low body mass index, and reduced muscle mass) and etiologic criteria (reduced intake or assimilation and inflammation).

Results:
Seventy-five (32.9%) of 228 patients were classified as suffering from malnutrition. Preoperative malnutrition was associated with an increased risk of estimated blood loss (mL) (816.7 ± 875.2 vs 593.1 ± 489.9, P = 0.015) and longer hospital stay (days) (27.3 ± 15.7 vs 22.9 ± 17.7, P = 0.045). The median follow-up period was 24.5 months. The malnutrition group had poor overall survival compared with “without (WO)-malnutrition” group (P = 0.001) at 1 year (66.3% vs 81.3%), 3 years (18.0% vs 51.8%), and 5 years (12.0% vs 39.3%). The malnutrition group showed poor disease-free survival and cancer-specific survival compared with WO-malnutrition group (P = 0.001) at 1 year (38.9% vs 66.7%) and (69.0% vs 88.7%), 3 years (11.5% vs 45.1%) and (21.1% vs 61.6%), and 5 years (11.5% vs 37.3%) and (14.1% vs 51.2%). In multivariate analysis, the preoperative malnutrition was found to be the predictor of poor prognosis (harzard ratio = 2.29, 95% confidence interval = 1.60–3.29, P = 0.001).

Conclusions:
Preoperative malnutrition is associated with poor prognosis in patients who underwent curative PD for pancreatic head cancer.
Experiences of involuntary job loss and health during the economic crisis in Portugal
Authors: Macassa Gloria , Rodrigues Carina , Barros Henrique , Marttila Anneli 
Published: February 2021

Abstract

Background:
The economic recession that started in 2008 left many unemployed across several European countries. Many studies have analyzed the relationship between job loss, health, and well-being in other contexts. This study aimed to explore experiences of involuntary unemployment during the economic recession and their relationship with health, conceptualized as a state of physical, mental, and social well-being among unemployed individuals.

Methods:
Semistructured qualitative interviews were carried out among a convenience sample of participants who became unemployed during the economic recession. The analysis was conducted to identify patterns and themes.

Results:
Participants (n = 22; 8 men and 14 women; 23–51 years) experienced feelings of loss of identity, stress, and a sense of powerlessness due to unemployment, as well as a lack of purpose and structure in their daily lives. Six themes were identified: work as the basis for life structure and personal fulfillment; response to unemployment and the importance of its duration; unemployment leading to isolation and loss of a role in society; impact of a change in financial situation on social life and consumption patterns; the physical and psychological health consequences of unemployment; and searching for ways to cope with unemployment and to feel well.

Conclusions:
Losing a job is an adverse experience that impairs an individual's perception of overall health and well-being. From a public health perspective, the results of this study highlight the need for policymakers’ awareness to help mitigate the potential consequences of involuntary job loss in the short- and long-term.
Do epigenetic clocks provide explanations for sex differences in lifespan? A cross-sectional twin study
Authors: Kankaanpää Anna , Tolvanen Asko , Saikkonen Pirkko , Heikkinen Aino , Laakkonen Eija K. , Kaprio Jaakko , Ollikainen Miina , Sillanpää Elina 
Published: February 2021

ABSTRACTBackgroundThe sex gap in life expectancy has been narrowing in Finland over the past four to five decades; however, on average, women still live longer than men. Epigenetic clocks are markers for biological aging that predict lifespan. In this study, we examined the mediating role of lifestyle factors on the association between sex and biological aging in younger and older adults.MethodsOur sample included same-sex younger and older twins (21-42-y, n = 1110; 50-76-y, n = 763) and younger opposite-sex twins (21-30-y, n = 302). Blood-based DNA methylation (DNAm) was used to compute epigenetic age acceleration by four epigenetic clocks as a measure of biological aging. Path modelling was used to study whether the association between sex and biological aging is mediated through lifestyle-related factors, i.e. education, body mass index, smoking, alcohol use, and physical activity.FindingsIn comparison to women, men were biologically older and, in general, they had unhealthier life habits. The effect of sex on biological aging was partly mediated by smoking, but only in older twins. Sex was directly associated with biological aging and the association was stronger in older twins.InterpretationPreviously reported sex differences in lifespan are also evident in biological aging. Declining smoking prevalence among men is a plausible explanation for the narrowing of the difference in life expectancy between the sexes. Data generated by the epigenetic clocks may help in estimating the effects of lifestyle and environmental factors on aging and in predicting aging in future generations.
Characterization of the different behaviours exhibited by juvenile grey mullet (Mugil cephalus) under rearing conditions
Authors: Jimenez-Rivera Jessica A. , Boglino Anaïs , Linares-Cordova Joel F. , Duncan Neil J. , de Lourdes Ruiz-Gómez María , Planellas Sonia Rey , Ibarra-Zatarain Zohar 
Published: February 2021

AbstractThis research described the common behaviour of grey mullet (Mugil cephalus) under rearing conditions. The different behaviours exhibited by mullets were videorecorded with submersible cameras installed inside of three tanks. A total of 690 minutes per day (07:30 - 18:30 hours) were recorded per tank during a week. Afterwards, an ethogram was elaborated to organize the different behaviours exhibited by juvenileM. cephalus, with two general categories: a) locomotion, including three different observed behaviours (resting, swimming and fast swimming) b) feeding, including three behaviours (surface feeding, bottom feeding and rubbing). The video recordings showed thatM. cephalusis a species with a constant locomotion associated to feeding, since they showed constantly movement during most of day light period the opposite to dark periods. Mullets were observed to be a non-aggressive fish species, due to the absence of dominance and aggression towards conspecifics, resulting in a high predisposition for adaptation to captivity. Finally, behavioural frequencies of grey mullet’s juveniles were not significantly different among the three tanks for most of the behavioural variables analysed (p>0.05) except for the variable bottom feeding (p=0.02). Results from this study could be of interest to the aquaculture industry to implement protocols and to optimize rearing techniques for the production of grey mullet.
The nanoscale organization of the Wnt signaling integrator Dishevelled in the development-essential vegetal cortex domain of an egg and early embryo
Authors: Henson John H. , Samasa Bakary , Shuster Charles B. , Wikramanayake Athula H. 
Published: February 2021

AbstractWnt/β-catenin (cWnt) signaling is a crucial regulator of development and Dishevelled (Dsh/Dvl) functions as an integral part of this pathway by linking Wnt binding to the frizzled:LRP5/6 receptor complex with β-catenin-stimulated gene expression. In many cell types Dsh has been localized to ill-defined cytoplasmic puncta, however in sea urchin eggs and embryos confocal fluorescence microscopy has shown that Dsh is localized to puncta present in a novel and development-essential vegetal cortex domain (VCD). In the present study, we used super-resolution light microscopy and platinum replica TEM to provide the first views of the ultrastructural organization of Dsh within the sea urchin VCD. 3D-SIM imaging of isolated egg cortices demonstrated the concentration gradient-like distribution of Dsh in the VCD, whereas higher resolution STED imaging revealed that some individual Dsh puncta consisted of more than one fluorescent source. Platinum replica immuno-TEM localization showed that Dsh puncta on the cytoplasmic face of the plasma membrane consisted of aggregates of pedestal-like structures each individually labeled with the C-terminus specific Dsh antibody. These aggregates were resistant to detergent extraction and treatment with drugs that disrupt actin filaments or inhibit myosin II contraction, and coexisted with the first division actomyosin contractile ring. These results confirm and extend previous studies and reveal, for the first time in any cell type, the nanoscale organization of plasma membrane tethered Dsh. Our current working hypothesis is that these Dsh pedestals represent a prepositioned scaffold organization that is important for canonical Wnt pathway activation at the sea urchin vegetal organization and may also be relevant to the submembranous Dsh puncta present in other eggs and embryos.