bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification And Analysis Of Potential Risk Factors Influencing The Road Safety Level At Designated Pedestrian Crossings
Authors: Pauer Gábor , Krizsik Nóra , Szigeti Szilárd , Hamza Zsolt 
Published: December 2021

Abstract
According to the data of the European Road Safety Observatory, around 21% of all road fatalities are suffered by pedestrians in the EU. In 2019 in Hungary, road accidents of pedestrians have had a share of 14,6% in all road accidents with personal injuries, which meant 2535 accidents in which one or more pedestrians were injured. A significant proportion of the accidents occurred at designated pedestrian crossings (43,1% of pedestrian accidents in 2019), and this trend increased over the last 5 years. To account the problem, Institute for Transport Sciences Non-profit Ltd. conducted a research focusing on the identification of potential risk factors which may have a negative impact on the level of traffic safety of designated pedestrian crossings in urban areas. Analysis and ranking of the risk factors have been carried out based on experts’ evaluation and scoring, with the use of statistical methods. The results of the work explore the risks that need to be addressed with special attention during the review of existing, and the establishment of new pedestrian crossings.
The Development Of Brigthness Evaluation Method For Digital Billboards
Authors: Krumina Gunta , Volberga Liva , Ikaunieks Gatis , Naumovs Lauris 
Published: December 2021

Abstract
LED-based billboards are becoming increasingly popular due to their low cost, flexibility, and efficiency. On another side, the too-bright digital billboard may pose a potential threat to road safety. The driver’s perception of advertising depends on the different factors, including the billboard’s luminance value. The aim of the study was to develop the assessment method for the digital screen parameters (luminance or illumination) which could be applied by supervising authorities, using budget-friendly devices, such as a lux meter and could be used during the billboard active operation. We tested the recommended method of OAAA and concluded that it is not applied for large billboards (over 25 square-meter) due to the calculated far distance and low sensitivity of lux meter. We have developed the new method based on driver discomfort glare and De Boer ratio. The ratio helps to determine how likely a display is to cause discomfort to those around it. The lower the value, the less discomfort the driver will experience from the billboard. The new method is applied for the active and different size billboard and using lux meter that is not an expensive device. Moreover, we take into account the glare effect of billboard on drivers’ vision.
Use Of BIM In SLLC “Latvian State Roads” For Process Managment
Authors: Krūmiņš Zigmārs , Smirnovs Juris , Āmare Valentina , Auziņš Roberts 
Published: December 2021

Abstract
BIM is an integrated set of building design, construction and management processes, technologies and regulations that allow all parties involved to jointly design, build and manage a building in a digital environment.
In Europe, a common approach to the use and adaptation of technologies is currently being developed with the aim of providing a common regulatory framework that would promote the efficiency of technology application between the countries of the European Union. The use of BIM technologies is based on economic (financial) benefits. The financial benefits are estimated in the long run, and the main factors for financial savings are productivity and quality, which can be achieved by applying BIM technology and appropriate processes during the construction cycle (design, construction and management). Studies show that savings can reach up to 10% of construction costs.
Currently underway is the process of implementing and configuring the Microsoft Dynamics platform for processing and using work information of SJSC "Latvian State Roads" (LSR). Microsoft Dynamics is a line of enterprise resource planning and customer relationship management software.
In general, LSR intends to use the system in the following stages of the construction cycle:
• Design stage
• Construction procurement stage
• Construction stage
• Warranty period
Microsoft Dynamic has both pros and cons for processing LSR information. Only after full implementation it will be possible to assess the effectiveness of this platform.
Objective of the article is to explore how the use of BIM can improve the LSR work process and what happening at this moment in LSR.
Impact of Racial Categorization on Effect Estimates: An HIV Stigma Analysis
Authors: Facente Shelley N , Lam-Hine Tracy , Bhatta Dharma N , Hecht Jennifer 
Published: December 2021

Abstract
Suboptimal racial categorization potentially introduces bias in epidemiologic analysis and interpretation, making it difficult to appropriately measure factors leading to racial health disparities. As part of an analysis focused on predictors of experiencing human immunodeficiency status (HIV)-related stigma among men who have sex with men living with HIV in San Francisco, we struggled with the most appropriate ways to categorize people who reported more than 1 racial identity, and we aimed to explore the implications of different methodological choices in this analysis. We fitted 3 different multivariable linear regression models, each utilizing a different approach to racial categorization: the “multiracial,” “othering,” and “hypodescent” models. We estimated an adjusted risk difference in mean score for reported frequency of experiencing HIV-related stigma on a 4-point scale, adjusting for age, race, gender identity, injection history, housing, mental health concerns, and viral load. Use of a hypodescent model for racial categorization led to a shift in the point estimate through the null for Blacks/African Americans, and it improved precision for that group. However, it obscured the association of increased stigma and race for multiracial people, compared with monoracial counterparts. We conclude that methodological decisions related to racial categorization of participants can dramatically affect race-related study findings in predictor regression models.
O-L06 The use of tumour marker Ca19.9 in the follow up of patients with resected biliary tract cancer: Results from the BILCAP randomised clinical trial
Authors: Morrison-Jones Victoria , Gao Fangfei , Fletcher Peter , Valle Juan , James Garden O , Cunningham David , Bridgewater John , Primrose John ,   BILCAP Study Group
Published: December 2021

Abstract

Background
Even after resection biliary tract cancer has a poor outlook. Follow-up is commonly utalises and the sialyl-Lewis tetra saccharide antigen Ca19.9, a known tumour marker in pancreatic and biliary malignancy (upper limit of normal (ULN) 37U/ml). However, the evidence base for the utility of Ca19.9 is limited. The UK BILCAP trial examined the use of adjuvant capecitabine chemotherapy in resected biliary tract cancer and establishing a new global standard of care. Ca19.9 was regularly measured as part of the BILCAP protocol, this provides an opportunity to assess the use of this marker in a large trial with complete patient follow-up.

Methods
Between March 2006 and December 2014 447 patients underwent resectional surgery (R0 or R1) then were randomised to receive capecitabine chemotherapy or observation. CT imaging and Ca19.9 were performed 3 monthly in year 1, 6 monthly in year 2, and annually thereafter up to 5 years. Follow up was continued until all patients had 5 years follow-up. Recurrence was based mainly on imaging criteria combined with the clinical presentation. The cohort was divided into progression and non- progression groups and the Ca19. 9 values recorded were investigated using descriptive analyses with cut-off of 37 (ULN), 100 and 400U/ml.

Results
Of 447 study patients 440 had at least one Ca19.9 measurement from either post-operative baseline (394) or a follow-up visit (422). Baseline Ca19-9 was elevated above 37U/ml in 96 patients and 82 (85%) went on to develop recurrence. The sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPV) of the Ca19.9 on follow up are shown in the table.

Conclusions
Although high Ca19.9 levels predict recurrence as shown by acceptable positive predictive values at cut-offs of 100 and 400U/ml the negative predictive values are very poor as most patients develop recurrence without elevation of Ca19.9. Ca19.9 measurement is of very limited value in the follow up of patients with resected biliary cancer.
O-P03 A composite polymeric nanoparticle as a sensitiser for sonodynamic therapy (SDT)-based treatment of pancreatic cancer
Authors: Farrell Sian , Nesbitt Heather , Mairs Laura , Nomikou Nikolitsa , Callan Bridgeen , Callan John F. , McHale Anthony P. 
Published: December 2021

Abstract

Background
Pancreatic cancer remains one of the most recalcitrant forms of cancer with poor prognosis and limited treatment options. SDT is a novel, targeted approach to the treatment of solid tumours. Based on the generation of cytotoxic reactive oxygen species (ROS) following the exposure of a sonosensitiser to ultrasound, the approach is designed to extracorporeally target less accessible lesions. Here we describe the production of a poly(lactic-co-glycolic acid) (PLGA), polyethyleneimine (PEI), Rose Bengal (RB) and indocyanine green (ICG) containing composite nanoparticles and describe their use in SDT-mediated treatment of pancreatic cancer using both in vitro and in vivo target models.

Methods
Nanoparticles were prepared using an oil in water emulsion and solvent diffusion-based approach. These were designated RB-ICGNP. In vitro SDT treatment consisted of exposing BxPC3 (human PDAC cells), T110029 (murine PDAC cells) or hPSC (immortalised human pancreatic stellate cells) to RB-ICGNP and subsequently treating with ultrasound for 30 s at a frequency of 1 MHz, a power density of 3.0 W/cm2 (SATP) using a duty cycle of 50% at a pulse repetition frequency of 100 Hz. For in vivo studies, BxPC3 (xenograft) and T110029 (syngeneic) tumours were treated with a power density of 3.5 W/cm2 ultrasound for 3.5 min.

Results

Conclusions
Using in vitro and in vivo (human xenograft and murine syngeneic) models of pancreatic cancer, RB-ICGNP composite nanoparticles may be employed as a sensitiser for SDT-based treatment of pancreatic cancer. Since pancreatic stellate cells were more sensitive to SDT, the latter may have an impact on tumour stroma. Staining of residual tumour tissues from SDT-treated animals for connective tissue (stroma) confirmed the latter. Since tumour stroma presents a significant challenge to treatment of pancreatic cancer and represents a negative prognostic marker, the impact delivered by SDT may be exploited to potentiate alternative therapeutic approaches.
A novel polypeptide vaccine and adjuvant formulation of EV71
Authors: Liu Zhiang , Yang Yunfan , Meng ChenChen , Fan Meihua , Guo Jing , Li Jie , Jing Zepeng , Wang Pingping , Li Ruipeng , Feng Zhiwei , Ren Feng , Wang Mingyong , Zhao Tiesuo 
Published: December 2021

ABSTRACT
Hand foot and mouth disease (HFMD) is an infectious disease mainly caused by Enterovirus 71 (EV 71). However, the effective treatment is limited currently. The aim of this study was to investigate the activity of the vaccine including the EV71 polypeptides mixed with a novel adjuvant containing CpG oligodeoxynucleotides (CpG ODNs). After collecting mouse sera, we determined the antibody concentration in serum by enzyme-linked immunosorbent assays (ELISA). Then, CD19+CD27+ B cells in the spleen were analysed by flow cytometry. The assay revealed that a substantial increase in antibody titers was achieved. This indicates a high level of immunogenicity for peptide vaccine and the good stability of adjuvant, also suggests that the combination of vaccine and adjuvant can stimulate the production of high-level antibodies and CD19+CD27+ B lymphocytes in mice. Furthermore, the antibody could effectively identify EV71 inactivated virus. The results demonstrated that the autonomous construction of EV71 polypeptide vaccine had a good immunogenicity. Moreover, the peptide vaccine injection with a novel adjuvant, which is easy to prepare, could cause a high antibody level of EV71 and shown a good application prospect.
Crystal structure of endocrine-disrupting chemical bisphenol A and estrogen-related receptor γ
Authors: Matsushima Ayami , Teramoto Takamasa , Kakuta Yoshimitsu 
Published: December 2021

Abstract
The human estrogen-related receptor γ (ERRγ) is an orphan nuclear receptor. The ERRγ behaves as a constitutive activator of transcription and plays a key role in controlling mitochondrial energy production and energy metabolism. Bisphenol A (BPA) is used mainly in producing polycarbonate plastics and epoxy resins, but it is known as an endocrine disruptor and strongly binds to ERRγ. We determined the crystal structure of ERRγ in complex with BPA. Our structure revealed the molecular mechanism of BPA recognition by ERRγ, in which BPA is well anchored to its ligand-binding pocket. Our structure is the first report of the complex between a nuclear receptor and endocrine disruptor BPA. This structural analysis had a profound impact on subsequent studies of endocrine disruptors.
Ileocecal intussusception as the initial presentation of endometriosis: case report
Authors: Pinsak Agustin E , Pantoja Pachajoa Diana A , Palacios Huatuco René M , Viscido Germán R , Mandojana Facundo I , Doniquian Alejandro M 
Published: December 2021

Abstract
Cecal endometriosis is a rare entity that can present as nonspecific acute abdominal pain and can be complicated by ileocolic intussusception, which is extremely infrequent. We present the case of a 33-year-old woman with no relevant pathological antecedents who consulted for abdominal pain for 5 days, associated with rebound tenderness and abdominal guarding on the right lower quadrant and a palpable mass during the physical examination. Computed tomography was realized and emergency surgery performed due to suspected ileocolic intussusception. The laparoscopic examination identified an ileocolic intussusception associated with a tumor. Conversion to open surgery was needed, and an oncological right hemicolectomy with ileotransverse anastomosis was carried out. Histopathological study reported ileocolic intussusception and a focus of cecal endometriosis. Currently, the patient does not have recurrences. Ileocolic intussusception secondary to deep endometriosis requires great diagnostic presumption in women of childbearing age with acute abdomen diagnosis.
3coSoKu and its declarative modeling
Authors: Rizzo Nicola , Dovier Agostino 
Published: December 2021

Abstract
In this paper, we analyze the physical puzzle IcoSoKu, a game about placing some given triangular tiles on the faces of an icosahedron in order to fill the capacities of its vertices, and we propose its generalization called 3coSoKu, admitting an arbitrary playing field with triangular faces, arbitrary capacities and an arbitrary set of triangular tiles. First, we prove the strong NP-completeness of 3coSoKu, even when the playing field is a convex polyhedron with equilateral triangles as faces. Second, we encode 3coSoKu both in the constraint modeling language MiniZinc and in the logic programming paradigm known as Answer Set Programming and we develop a visual tool for an accessible interface to the solver. Finally, we use our encodings to verify experimentally that every initial state for IcoSoKu admits a solution.
Underuse and Variability in Substance Use Screening Among Adult Trauma Patients in the U.S.
Authors: Alser Osaid , Perez Numa P. , Gebran Anthony , Maurer Lydia R. , Ortega Gezzer , Velmahos George C. , Kaafarani Haytham M.A. , Masiakos Peter T. 
Published: December 2021

Objective:
To characterize the rates and variability in substance screening among adult trauma patients in the U.S.

Summary Background Data:
Emergency Department trauma visits provide a unique opportunity to identify patients with substance use disorders. Despite the existence of screening guidelines, underscreening and variability in screening practices remain.

Methods:
Retrospective cohort study including adult trauma patients (18– 64–year–old) from the ACS-TQIP 2017–18 database. Multivariable logistic regressions were performed to adjust for demographics, clinical, and facility factors, and marginal probabilities were calculated using these multivariable models. The primary outcomes were substance screening and positivity, which were defined relative to the observation-weighted grand mean (mean).

Results:
2,048,176 patients were contained in the TQIP dataset, 809,878 (39.5%) were screened for alcohol (20.8% positive), and 617,129 (30.1%) were screened for drugs (37.3% positive). After all exclusion criteria were applied, 765,897 patients were included in the analysis, 394,391 (52.9%) were screened for alcohol (22.1% tested positive), and 279,531 (36.5%) were screened for drugs (44.3% tested positive). Among the patients included in our study, significant variability in screening rates existed with respect to demo–graphic, trauma mechanism, injury severity, and facility factors. Furthermore, in several cases, patient subpopulations who were less likely to be screened were in fact more likely to screen positive or vice versa.

Conclusions:
Effective substance-screening guidelines should be predicated on achieving universal screening. Current lapses in screening, along with the observed variability, likely affect different patient populations in disparate manners and lead to both under-detection as well as waste of valuable resources.
Association of Early Bifurcation of Hepatic Artery With Arterial Injury in Right-Sided Living-Donor Hepatectomy
Authors: Kusakabe Jiro , Taura Kojiro , Sasaki Kazunari , Yagi Shintaro , Doi Junshi , Ogiso Satoshi , Hatano Etsuro 
Published: December 2021

Objective:
The aim of this study was to explore the incidence of early bifurcation of the right hepatic artery (RHA) and the right posterior hepatic artery (RPHA), which is crucial in right lobe graft (RLG) and right posterior sector graft (RPSG) procurement for living-donor liver transplantation.

Summary Background Data:
Early bifurcation of the hepatic artery tends to induce oversight of one of the bifurcated arteries and its injury in RLG/RPSG procurement. Unrecognizable on conventional 3-dimensional (3-D) images, its significance is underestimated.

Methods:
We enrolled 500 patients who underwent preoperative imaging for scheduled surgeries at two major transplant centers. All-in-one 3-D images consisting of the hepatic artery, portal vein, and bile duct were constructed. Early bifurcation of the RHA and the RPHA was defined as the arteries bifurcating proximal to the cutting line of the right hepatic duct and the right posterior duct, respectively.

Results:
Early bifurcation of the RHA was seen in 11.3% of cases of an infra-portal RPHA and in 46.0% of cases of a supraportal RPHA (P < 0.001). Early bifurcation of the RPHA was encountered in 35.3% of cases of an infra-portal RPHA, in no cases of a supra-portal RPHA, and in 100% of cases in which the arteries to segment 6/7 arose individually from the RHA. The overall incidence of early bifurcation was 19.9% for RHA and 43.6% for RPHA.

Conclusions:
Early bifurcation of the RHA and the RPHA is frequently encountered and requires caution for RLG/RPSG procurement. Special attention should be paid to supraportal RPHA for RLG procurement.
Using synthetic controls to estimate the population-level effects of Ontario’s recently implemented overdose prevention sites and consumption and treatment services
Authors: Panagiotoglou Dimitra , Lim Jihoon 
Published: December 2021

ABSTRACTBackgroundBetween 2017 and 2020, Ontario implemented overdose prevention sites (OPS) and consumption and treatment services (CTS) in nine of its 34 public health units (PHU). We tested for the effect of booth-hours (spaces within OPS/CTSs for supervised consumption) on opioid-related health service use and mortality rates at the provincial-(aggregate) and PHU-level.MethodsWe used monthly rates of all opioid-related emergency department (ED) visits, hospitalizations, and deaths between January 2015 and March 2021 as our three outcomes. For each PHU that implemented OPS/CTSs, we created a synthetic control as a weighted combination of unexposed PHUs. Our exposure was the time-varying rate of booth-hours provided. We estimated the population-level effects of the intervention on each outcome per treated/synthetic-control pair using controlled interrupted time series with segmented regression; and tested for the aggregate effect using a multiple baseline approach. We adjusted for time-varying provision of prescription opioids for pain management, opioid agonist treatment (OAT), and naloxone kits; and corrected for seasonality and autocorrelation. All rates were per 100,000 population. For sensitivity analysis, we restricted the post-implementation period to before COVID-19 public health measures were implemented (March 2020).ResultsOur aggregate analyses found no effect per booth-hour on ED visit (0.00, 95% CI: -0.01, 0.01; p-value=0.6684), hospitalization (0.00, 95% CI: 0.00, 0.00; p-value=0.9710) or deaths (0.00, 95% CI: 0.00, 0.00; p-value=0.2466). However, OAT reduced ED visits (−0.20, 95% CI: -0.35, -0.05; p-value=0.0103) and deaths (−0.04, 95% CI: -0.05, -0.03; p-value=<0.0001). Conversely, prescription opioids for pain management modestly increased deaths (0.0008, 95% CI: 0.0002, 0.0015; p-value=0.0157) per 100,000 population, respectively. Except for a few treated PHU/synthetic control pairs, disaggregate results were congruent with overall findings.ConclusionBooth-hours had no population-level effect on opioid-related overdose ED visit, hospitalization, or death rates.
Towards long term monitoring: Seizure detection with reduced electroencephalogram channels
Authors: Maher Christina , Yang Yikai , Truong Nhan Duy , Wang Chenyu , Nikpour Armin , Kavehei Omid 
Published: December 2021

AbstractEpilepsy is a prevalent condition characterised by recurrent, unpredictable seizures. The diagnosis of epilepsy is by surface electroencephalography (EEG), a time-consuming and uncomfortable process for patients. The diagnosis of seizures using EEG over a brief monitoring period has variable success, dependent on patient tolerance and seizure frequency. Further, the availability of hospital resources, and hardware and software specifications inherently limit the capacity to perform long-term data collection whilst maintaining patient comfort. The application and maintenance of the standard number of electrodes restrict recording time to a maximum of approximately ten days. This limited monitoring period also results in limited data for machine learning models for seizure detection and classification. This work examines the literature on the impact of reduced electrodes on data accuracy and reliability in seizure detection. We present two electrode ranking models that demonstrate the decline in seizure detection performance associated with reducing electrodes. We assert the need for further research in electrode reduction to advance solutions toward portable, reliable devices that can simultaneously provide patient comfort, long-term monitoring and contribute to multimodal patient care solutions.