bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Association Analysis of 21-Gene Recurrence Score and Obesity in Chinese Breast Cancer Patients
Authors: Tong Yiwei , Gao Weiqi , Wu Jiayi , Zhu Siji , Huang Ou , He Jianrong , Zhu Li , Chen Weiguo , Li Yafen , Shen Kunwei , Chen Xiaosong 
Published: March 2021

PurposeA center-specific 21-gene recurrence score (RS) assay has been validated in Luminal-like, HER2-, pN0-1 Chinese breast cancer patients with both predictive and prognostic value. The association between RS and host factors such as obesity remains unclear. The objectives of the current study are to comprehensively analyze the distribution, single gene expression, and prognostic value of RS among non-overweight, overweight and obese patients.Patients and methodsLuminal-like patients between January 2009 and December 2018 were retrospectively reviewed. Association and subgroup analysis between BMI and RS were conducted. Single-gene expression in RS panel was compared according to BMI status. Disease-free survival (DFS) and overall survival (OS) were calculated according to risk category and BMI status.ResultsAmong 1876 patients included, 124 (6.6%), 896 (47.8%) and 856 (45.6%) had RS &lt; 11, RS 11-25, and RS ≥ 26, respectively. Risk category was significantly differently distributed by BMI status (P=0.033). Obese patients were more likely to have RS &lt; 11 (OR 2.45, 95% CI 1.38-4.35, P=0.002) compared with non-overweight patients. The effect of BMI on RS significantly varied according to menstruation (P&lt;0.05). Compared to non-overweight patients, obese ones presented significantly higher ER, PR, CEGP1, Ki67, CCNB1 and GSTM1 (all P&lt;0.05) mRNA expression, and such difference was mainly observed in postmenopausal population. After a median follow-up of 39.40 months (range 1.67-119.53), RS could significantly predict DFS in whole population (P=0.001). RS was associated with DFS in non-overweight (P=0.046), but not in overweight (P=0.558) or obese (P=0.114) population.ConclusionsRS was differently distributed among different BMI status, which interacted with menopausal status. Estrogen receptor and proliferation group genes were more expressed in obese patients, especially in postmenopausal population.
Comparison of Caudal Block vs. Penile Block vs. Intravenous Fentanyl Only in Children Undergoing Penile Surgery: A Prospective, Randomized, Double Blind Study
Authors: Ekstein Margaret , Weinbroum Avi A. , Ben-Chaim Jacob , Amar Eyal , Schvartz Reut , Klein Yifat , Bar-Yosef Yuval 
Published: March 2021

Objectives: Penile surgery is commonly performed in pediatric surgical centers. There is no consensus regarding which analgesic method is most effective in controlling pain in these children.Methods: Consecutive children between 4 months and 16 years of age who underwent elective penile surgery were recruited. After inhaled induction of anesthesia, children were randomized to one of three methods of intraoperative analgesia: caudal block, IV fentanyl titrated to surgical response and spontaneous respiration, or dorsal penile nerve block (DPNB). All patients were given inhaled agents; fentanyl was added if either block was insufficient. Demographic data, analgesic use and pain scores were recorded by a blinded investigator in the PACU and ward. Pain scores, analgesic requirement, and recovery parameters of returning to normal activity level, eating, and voiding post-operatively for up to 4 days, were compared.Results: 116 children were recruited. Pain scores in the post anesthesia care unit were significantly lower in the DPNB and caudal block groups compared to the fentanyl group for the first 30 postoperative min. Pain scores and analgesic use were subsequently similar among the three groups for the rest of the study period. There was no statistical difference in time to eat, return to normal activity or in parental satisfaction scores among the groups. There was a trend toward earliest time to void in the DPNB group.Conclusions: Regional blocks most effectively controlled pain for 30 min after surgery. The choice of intra-operative analgesia protocol had no effect on later pain and recovery parameters.
Neuroprotective Effect of Astragaloside IV on Cerebral Ischemia/Reperfusion Injury Rats Through Sirt1/Mapt Pathway
Authors: Shi Yi-Hua , Zhang Xi-Le , Ying Peng-Jie , Wu Zi-Qian , Lin Le-Le , Chen Wei , Zheng Guo-Qing , Zhu Wen-Zong 
Published: March 2021

Background: Ischemic stroke is a common disease with poor prognosis, which has become one of the leading causes of morbidity and mortality worldwide. Astragaloside IV (AS-IV) is the main bioactive ingredient of Astragali Radix (which has been used for ischemic stroke for thousands of years) and has been found to have multiple bioactivities in the nervous system. In the present study, we aimed to explore the neuroprotective effects of AS-IV in rats with cerebral ischemia/reperfusion (CIR) injury targeting the Sirt1/Mapt pathway.Methods: Sprague–Dawley rats (male, 250–280 g) were randomly divided into the Sham group, middle cerebral artery occlusion/reperfusion (MCAO/R) group, AS-IV group, MCAO/R + EX527 (SIRT1-specific inhibitor) group, and AS-IV + EX527 group. Each group was further assigned into several subgroups according to ischemic time (6 h, 1 d, 3 d, and 7 days). The CIR injury was induced in MCAO/R group, AS-IV group, MCAO/R + EX527 group, and AS-IV + EX527 group by MCAO surgery in accordance with the modified Zea Longa criteria. Modified Neurological Severity Scores (mNSS) were used to evaluate the neurological deficits; TTC (2,3,5-triphenyltetrazolium chloride) staining was used to detect cerebral infarction area; Western Blot was used to assess the protein levels of SIRT1, acetylated MAPT (ac-MAPT), phosphorylated MAPT (p-MAPT), and total MAPT (t-MAPT); Real-time Quantitative Polymerase Chain Reaction (qRT-PCR) was used in the detection of Sirt1 and Mapt transcriptions.Results: Compared with the MCAO/R group, AS-IV can significantly improve the neurological dysfunction (p &lt; 0.05), reduce the infarction area (p &lt; 0.05), raise the expression of SIRT1 (p &lt; 0.05), and alleviate the abnormal hyperacetylation and hyperphosphorylation of MAPT (p &lt; 0.05). While compared with the AS-IV group, AS-IV + EX527 group showed higher mNSS scores (p &lt; 0.05), more severe cerebral infarction (p &lt; 0.05), lower SIRT1 expression (p &lt; 0.01), and higher ac-MAPT and p-MAPT levels (p &lt; 0.05).Conclusion: AS-IV can improve the neurological deficit after CIR injury in rats and reduce the cerebral infarction area, which exerts neuroprotective effects probably through the Sirt1/Mapt pathway.
Signal Fingerprinting as a Novel Diagnostic Tool to Identify Conduction Inhomogeneity
Authors: Ye Ziliang , van Schie Mathijs S. , de Groot Natasja M. S. 
Published: March 2021

BackgroundInhomogeneous intra-atrial conduction facilitates both initiation and perpetuation of atrial fibrillation (AF) and is reflected in electrogram (EGM) morphology.ObjectiveThe primary objective of this study is to investigate regional differences in features of different EGM types during sinus rhythm (SR) and to design a patient-specific signal fingerprint, which quantifies the severity and extensiveness of inhomogeneity in conduction.MethodsPatients (N = 189, 86% male; mean age 65 ± 9 years) undergoing coronary artery bypass grafting (CABG) underwent high-resolution mapping of the right atrium (RA), left atrium (LA), and pulmonary vein area (PVA) including Bachmann’s bundle (BB). EGMs during 5 s of SR were classified as single potentials (SPs), short double potentials (SDPs, interval between deflections &lt; 15 ms), long double potentials (LDPs, deflection interval &gt; 15 ms), or fractionated potentials (FPs, ≥3 deflections). Of all SPs, differences in relative R- and S-wave amplitude were calculated (R/S ratios). Time difference between first and last deflection was determined (fractionation duration, FD) and potentials with amplitudes &lt; 1.0 mV were labeled as low-voltage. Conduction block (CB) was defined as a difference in local activation time (LAT) between adjacent electrodes of ≥12 ms.ResultsA total of 1,763,593 EGMs (9,331 ± 3,336 per patient) were classified (Table 1).ConclusionThe signal fingerprint, consisting of quantified EGM features, including the R/S ratio of SPs, the relative frequency distribution of unipolar voltages, the proportion of low-voltage areas, the proportion of the different types of EGMs, and durations of LDP and FDP, may serve as a diagnostic tool to determine the severity and extensiveness of conduction inhomogeneity. Further studies are required to determine whether the signal fingerprint can be used to identify patients at risk for AF onset or progression.
Occupational Burnout Among Frontline Health Professionals in a High-Risk Area During the COVID-19 Outbreak: A Structural Equation Model
Authors: Li Dan , Wang YuanYuan , Yu Hui , Duan Zhizhou , Peng Ke , Wang Nan , Zhou Qiang , Hu Xudong , Fang Ke , Wilson Amanda , Ou Jianjun , Wang Xiaoping 
Published: March 2021

Background: The outbreak of coronavirus disease 2019 (COVID-19) resulted in a substantial workload and stress for frontline health professionals in high-risk areas. Little research has investigated the mechanism of occupational burnout among the frontline health professionals located in the center of the epidemic in Wuhan, China.Methods: A total of 199 frontline health professionals from Wuhan Jinyintan Hospital completed the cross-sectional survey. Mechanisms of occupational burnout (according to the Maslach Burnout Inventory–General Survey, MBI-GS) among the health professionals in Jinyintan Hospital during the COVID-19 outbreak were examined using a structural equation model (SEM).Results: The levels of the three burnout dimensions (emotional exhaustion, cynicism, and professional efficacy) were high at 34.2, 50.8, and 35.2%, respectively. Frontline health professionals in this stressful period reported significantly greater emotional exhaustion (p &lt; 0.001) and job-related cynicism (p &lt; 0.001), but no significant difference in professional efficacy (p = 0.449), when compared to employees in a large multinational company. The SEM results revealed that both acute stress symptoms and psychosomatic symptoms significantly predicted the emotional exhaustion and occupation cynicism dimensions of burnout.Conclusion: The study reveals the occupational burnout mechanism of frontline health professionals during the COVID-19 peak at the time of the outbreak. This study provides an important contribution to understanding the future psychological interventions necessary for frontline health professionals during an epidemic crisis.
The Mediation Effect of Hyperarousal Symptoms on the Relationship Between Childhood Physical Abuse and Suicidal Ideation of Patients With PTSD
Authors: Kwon Aeran , Lee Hyun Seo , Lee Seung-Hwan 
Published: March 2021

Objective: This study examined the relationship of childhood physical abuse, posttraumatic stress disorder (PTSD), depression, and suicide in patients with PTSD through path analysis.Materials and Methods: A total of 114 patients with PTSD (36 men and 78 women) were recruited and completed psychological assessments including the Childhood Trauma Questionnaire, the scale for suicidal ideation, the clinician-administered PTSD scale for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the PTSD checklist, and the Hospital Anxiety and Depression Scale. Structural equation modeling was used to evaluate the results. We developed a model including childhood physical abuse experience as the causal variable, suicidal ideation as a result variable, and PTSD and depression as mediation variables. PTSD symptoms were divided into four clusters [intrusion, avoidance, negative cognition and mood, and altered arousal and reactivity (hyperarousal)] to determine predictive power for suicide.Results: PTSD symptoms fully mediated the relationship between childhood physical abuse and suicidal ideation. Furthermore, PTSD symptoms fully mediated the relationship between childhood physical abuse and depression. Among the PTSD symptoms, hyperarousal was the only symptom cluster that mediated the relationship between childhood physical abuse and suicidal ideation. The symptom clusters of negative cognition and mood as well as hyperarousal mediated the relationship between childhood physical abuse and depression.Conclusions: This study presents a link between childhood physical abuse and current symptoms in patients with PTSD, and highlights specific PTSD symptom clusters (i.e., hyperarousal, negative cognition and mood) that may increase the risk for psychopathology later in life.
HDAC Inhibition Induces Cell Cycle Arrest and Mesenchymal-Epithelial Transition in a Novel Pleural-Effusion Derived Uterine Carcinosarcoma Cell Line
Authors: Stockhammer Paul , Okumus Özlem , Hegedus Luca , Rittler Dominika , Ploenes Till , Herold Thomas , Kalbourtzis Stavros , Bankfalvi Agnes , Sucker Antje , Kimmig Rainer , Aigner Clemens , Hegedus Balazs 
Published: March 2021

Objective: Uterine carcinosarcoma (UCS) is a rare but highly aggressive malignancy with biphasic growth pattern. This morphology can be attributed to epithelial-mesenchymal transition (EMT) that often associates with tumor invasion and metastasis. Accordingly, we analyzed a novel patient-derived preclinical model to explore whether EMT is a potential target in UCS.Methods: A novel UCS cell line (PF338) was established from the malignant pleural effusion of a 59-year-old patient at time of disease progression. Immunohistochemistry was performed in primary and metastatic tumor lesions. Oncogenic mutations were identified by next-generation sequencing. Viability assays and cell cycle analyses were used to test in vitro sensitivity to different standard and novel treatments. E-cadherin, β-catenin and pSMAD2 expressions were measured by immunoblot.Results: Whereas immunohistochemistry of the metastatic tumor showed a predominantly sarcomatous vimentin positive tumor that has lost E-cadherin expression, PF338 cells demonstrated biphasic growth and carried mutations in KRAS, PIK3CA, PTEN and ARID1A. PF338 tumor cells were resistant to MEK- and TGF-β signaling-inhibition but sensitive to PIK3CA- and PARP-inhibition and first-line chemotherapeutics. Strikingly, histone deacetylase (HDAC) inhibition markedly reduced cell viability by inducing a dose-dependent G0/1 arrest and led to mesenchymal-epithelial transition as evidenced by morphological change and increased E-cadherin and β-catenin expression.Conclusions: Our data suggest that HDAC inhibition is effective in a novel UCS cell line by interfering with both viability and differentiation. These findings emphasize the dynamic manner of EMT/MET and epigenetics and the importance of molecular profiling to pave the way for novel therapies in UCS.
ORIGAMI SEBAGAI TINDAKAN ADJUVANT ATRAUMATIC CARE TERHADAP TINGKAT KECEMASAN ANAK YANG MENJALANI HOSPITALISASI DI RSUD 45 KUNINGAN
Authors: Nengsih Neneng Aria 
Published: March 2021

Latar belakang: Ketika anak sakit dan mengharuskan dirawat di rumah sakit, membuat cemas anak dan keluarga karena harus berusaha beradaptasi dengan lingkungan asing. Salah satu intervensi keperawatan untuk membantu mengurangi kecemasan pada anak selama menjalani hospitalisasi adalah terapi bermain origami. Tujuan penelitian: menganalisis rerata tingkat kecemasan sebelum dan sesudah diberikan terapi origami pada anak usia prasekolah yang menjalani prosedur invasif infus saat hospitalisasi di Ruang Anak RSUD 45 Kuningan.
Metode penelitian: jenis penelitian ini adalah Pra Eksperimen dengan rancangan One Group Pretest And Posttest. Jumlah sampel dalam penelitian ini sebanyak 15 responden dengan menggunakan teknik Purposive Sampling. Pengambilan data dilakukan dengan cara mengukur tingkat kecemasan sebelum dan sesudah diberikan terapi bermain origami yang diukur menggunakan Preschool Anxiety Scale-Revised (2010). Selanjutnya data diolah dan dianalisis menggunakan uji Wilcoxon Signed Rank-test.
Hasil penelitian menunjukkan bahwa rerata tingkat kecemasan responden sebelum diberikan intervensi adalah sebesar 1,93 dan rerata sesudah diberikan intervensi terapi bermain origami adalah sebesar 1,20. Selisih rata-rata tingkat kecemasan sebelum dan sesudah dilakukan terapi adalah 0,73. Hasil uji statistik wilcoxon tentang pengaruh terapi bermain origami terhadap penurunan tingkat kecemasan pada anak prasekolah yang menjalani hospitalisasi dengan tingkat kepercayaan 95% (α = 0,05) sebesar P value (0,002) dengan demikian p value < 0,05), maka H0 ditolak. Hal ini berarti terdapat perbedaan tingkat kecemasan sebelum dan sesudah diberikan terapi bermain origami. Sehingga dapat disimpulkan bahwa ada pengaruh pemberian terapi bermain origami terhadap tingkat kecemasan anak yang menjalani prosedur invasif infus saat hospitalisasi di rumah sakit.
Diharapkan hasil penelitian ini dapat dikembangkan oleh peneliti lain terkait metode adjuvant lain yang dapat menurunkan tingkat kecemasan pada anak sebagai tindakan atraumatic care
Potential of AgBiI4 rudorffites for indoor photovoltaic energy harvesters in autonomous environmental nanosensors
Authors: Turkevych Ivan , Kazaoui Said , Shirakawa Naoki , Fukuda Nobuko 
Published: March 2021

Abstract
Harvesting of ambient renewable energy resources, such as indoor light, is a viable solution for the development of autonomous, “install-and-forget”, environmental nanosensors. In this work we fabricated and characterized photovoltaic cells based on AgBiI4 rudorffites as promising indoor photovoltaic energy harvesters demonstrating photoconversion efficiency of 5.17% and power output of 1.76 μW cm−2 measured under white LED light of 1000 lux. Considering that modern low-power wireless transmitters consume <1 μJ per bit for data transmission, the indoor rudorffite photovoltaic cell combined with a supercapacitor can be used for sensor readout and reliable intermittent data transmission.
Ultrasonic complex vibration source using two longitudinal vibration transducers and a uniform rod with diagonal slits
Authors: Saegusa Naoki , Asami Takuya , Miura Hikaru 
Published: March 2021

Abstract
It has been reported that ultrasonic welding using planar vibrations results in higher weld strength and less damage to the work pieces compared with ultrasonic welding using linear vibrations. However, torsional vibration transducers are small and expensive, thus reducing flexibility in the use of the vibration source. Therefore, in this study, we developed an ultrasonic longitudinal-torsional vibration source using longitudinal vibration transducers and a uniform rod with diagonal slits. The proposed vibration source generates torsional vibration by using a uniform rod with diagonal slits instead of a conventional torsional vibration transducer. As a result, it is found that a planar vibration locus is obtained by inputting two resonance frequencies simultaneously.
Peningkatan Prestasi Belajar Pendidikan Agama Islam Melalui Penerapan Pembelajaran Card Sort
Authors: Bardin  
Published: March 2021

Penggunaan metode pembelajaran yang tepat dapat memaksimalkan hasil capaian pembelajaran. Penelitian ini bertujuan untuk mengetahui upaya peningkatan prestasi belajar Pendidikan Agama Islam (PAI) melalui penerapan metode card sort. Metode penelitian tindakan (action research) dilakukan terhadap mata pembelajaran PAI tentang materi Rukun shalat pada siswa kelas IV SD Negeri 11 Simpang Rimba Kabupaten Bangka Selatan Tahun Ajaran 2019/2020. Indikator hasil penelitian menunjukkan bahwa persentase ketuntasan belajar pada tahap pra siklus sebesar 39,3%, siklus I 72,14%, dan siklus II mencapai 87,45%. Nilai rata-rata hasil tes siswa juga mengalami peningkatan yang signifikan yaitu pada tahap pra siklus 54,8, siklus I 73,3, dan siklus II meningkat menjadi 78,9. Penerapan metode Card sort dalam pembelajaran Pendidikan Agama Islam memudahkan guru dalam mencapai target pembelajaran yang diinginkan serta dapat mengoptimalkan suasana belajar siswa untuk menyempurnakan hasil belajar siswa. Selain itu, penerapan metode Card sort juga dapat merangsang dan memunculkan aktivitas siswa. Sehingga dapat disimpulkan dengan menggunakan metode pembelajaran card sort, prestasi belajar siswa pada materi pembelajaran Pendidikan Agama Islam mengenal rukun shalat dapat ditingkatkan.
The Scope of Repertoire: A Study in John Ashbery's Selected Poems
Authors: Qays Abid Assist. Instructor Khalid 
Published: March 2021

The current critical appreciations of the American poet John Ashbery (1927- ) have proved to be ambivalent to consider him as a later Romantic poet or a postmodern avant-garde, whose essential role is to achieve the postmodern project. Many of his major poems include a kind of repertoire that demonstrates a clear treatment of Romantic themes and implications tackled carefully by the poet. His later poems, however, are concerned with postmodern themes like the bewilderment of the American individual due to the unprecedented changes and watersheds the society witnessed. The main aim of this research is to critically examine selected poems of Ashbery to judge whether he is Romantic or postmodern, consulting cues from critics like Bloom, Miller and Longenbach . It is one of the fruitful conclusions that Ashbery adheres to the Romantic spirit but for unromantic intentions. Thus, he conveys confessional themes on one hand and tackles postmodern realistic themes related to the core of the American society in which he lives and writes on the other.
Analyzing Conversation in Children’s Short Stories
Authors: Hassan Instructor Nagham Ali 
Published: March 2021

Conversation analysis has long been the concern of many linguists who work in the field of discourse analysis. In spite of the fact that there are many researches have been done in the field of short stories but up to the researcher knowledge the investigation of the selected short stories has not been studied yet. Hence, this paper aims at answering the following questions: what are the features of children’s short stories language and the differences between short stories of four years old and those of six years old. Hence, the devices used by the story tellers in reciting the short stories should be observed. Thus, the researcher has consulted the models presented by Johnson and Fillmore (2010) to show tenses and sentence structure, and Smith (2008) for conversation analysis.In the light of the analysis according to Johnson and Fillmore (2010), the researcher has reached to the following results: It is clear that simple sentences and past simple tense are used more than the other devises due to the fact that it is the main features of children’s short stories language. The conversation of children’s short stories has also showed that the language of four years old is somehow similar to those of six years old. According to Smith (2008), it is clear that the language of children is similar to those of short stories then it is similar to those of real life conversation.
Study of The Text Messages Written on The Vehicles in Iraq As Popular Folk and Literature
Authors: Al-Bayati Assist. Prof. Najdat Yashar Murad 
Published: March 2021

Writings on cars are considered examples of folk literature since its meanings are similar to other features of folk literature productions such as proverbs and jokes ..etc .They are a reflection of character , thoughts, emotions, beliefs , moods, and ambitions of people and society . Till the present time, there is no comprehensive and scientific study of these writings neither in Iraq nor Turkey despite the fact that they represent distinctive aspect of culture and folklore . In this paper , examples of writings on cars in Iraq were collected and translated to Turkish language . In addition , explaining their meaning and comparing them to those writings that are common in Turkish society . And there is a reference to the role of the cultural factor between various societies, such as Iraqi society and Turkish society, in appearance of such writings