bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable rural tourism development in the era of social media shape identities and discourse digital settings
Authors: Laxmita N A , Setyaningsih W , Purwani O 
Published: June 2021

Abstract
This paper discusses about sustainable tourism creative initiative in the era of social media & digital settings The essence of a tour is an unusual experience, therefore an authentification of tourist attractions is one of the competitive advantages to meet those needs. So many tourist attractions process and develop to reach that goals without regard to environmental sustainability. Moreover, coupled with the ease of access from social media, tourism actors only aim for bussiness and management excellence. The location of this discriptive qualitative analysis research is in Ponggok Village, Klaten Regency. This study highlights the problem of how perspective of tourism development that shapes identity and meets the needs of today’s digital settings while still paying attention to environmental sustainability. It is necessary to develop scenarios to achieve optimal tourism offers. The purpose of writing this research is to know the perspective of scenario development to get a sensation on a tour by entering aspects of the identity of a place and as a discourse of digital settings. In effort to provide answers, the posibilities for implementation of these technologies for the purpose of research area increasing and have the power to change tourism mobility research as it stands today.
Design of Wireless Power Transfer System for Charging of Electronic Gadgets
Authors: Bhaskar Lala , Kumar Pradeep , Naik Mude Kishore 
Published: June 2021

Abstract
Wireless charging of gadgets is one of the new emerging technologies in the world at present moment. The most common method used is wireless power transfer is by using the method of inductive coupling. Wireless power transfer is one of the simplest and inexpensive ways of charging as it eliminates the use of conventional copper cables and current carrying wires. The inductive coupling technique is used since currently it is the easiest method of wireless power transfer because of high efficiency and large amount of the energy transferred. Its versatility and range of applications the power transferred will be used to charge a battery with the aid of additional circuitry. This research work focuses on the study of wireless power transfer for the purpose of transferring energy at maximum efficiency within a small range or in the near field region. The motivation to this proposed design model is contact less mobile device charging about 5cm-100cm distance range, which can be used to charge the mobile electronic devices like mobile phones, laptops, smart phones wirelessly. This proposed design is very helpful in the pandemic situation to charge electronic gadgets contactless as well wirelessly in the hospitals, public transports like metro stations, educational institutions, and in office communication systems.
Use of sustainable green materials in construction of green buildings for sustainable development
Authors: Patel Prutha , Patel Anant 
Published: June 2021

Abstract
Sustainability in building construction is now major priority as it is having various advantages. The global trend is moving towards the sustainability and hence sustainable building construction has prime importance in the construction industry. Due to huge urbanization activities lot of environmental issues are originating. Building construction using sustainable materials will lead to reduction in the pollution and also improve the existing situation of environmental problems. This paper discusses the use of recycled design products in the construction industry. Affordable sustainable housing projects made from locally available construction materials are in high demand. It safeguards the natural ecosystem, economy, and energy. As a result, the report considers unique products that could fulfil the minimum requirements for sustainable building construction. The primary goal of this research is to do a comparative review to determine the viability of using recycled building materials instead of conventional building materials.
Consequence of Modified Boundary Condition On Natural Convection in a Porous Medium Saturated by Nanofluid – A Computational Approach
Authors: Mitra Asish 
Published: June 2021

Abstract
In the present numerical simulation, steady, laminar, two-dimensional flow in a porous medium saturated by nanofluid [1] along an isothermal vertical plate is presented. Here we have studied a more realistic situation where the nanoparticle volume fraction at the plate (boundary condition) is passively controlled by assuming that its flux there is zero. We employ Boungiorno model [2] that treats the nanofluid as a two-component mixture, incorporating the effects of Brownian motion and thermophoresis. Darcy model is utilized for the presence of porous medium. With the help of appropriate similarity variables, the governing nonlinear partial differential equations of flow are changed to a bunch of nonlinear ordinary differential equations. Afterwards, they are reduced to a first order system and integrated using Newton Raphson and adaptive Runge-Kutta methods. The computer codes are developed for this numerical analysis in Matlab environment. Dimensionless stream function (s), longitudinal velocity (s’), temperature (θ) and nanoparticle volume fraction (f) are figured and outlined graphically for various values of four dimensionless parameters, namely, Lewis number (Le), buoyancy-ratio parameter (Nr), Brownian motion Parameter (Nb), and thermophoresis parameter (Nt). The dependence of the reduced Nusselt number on these parameters is illustrated.
Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure
Authors: Couch Liam S , Fiedler Jan , Chick Giles , Clayton Rory , Dries Eef , Wienecke Laura M , Fu Lu , Fourre Jerome , Pandey Pragati , Derda Anselm A , Wang Brian X , Jabbour Richard , Shanmuganathan Mayooran , Wright Peter , Lyon Alexander R , Terracciano Cesare M , Thum Thomas , Harding Sian E 
Published: June 2021

Abstract

Aims
Takotsubo syndrome (TTS) is an acute heart failure, typically triggered by high adrenaline during physical or emotional stress. It is distinguished from myocardial infarction (MI) by a characteristic pattern of ventricular basal hypercontractility with hypokinesis of apical segments, and in the absence of culprit coronary occlusion. We aimed to understand whether recently discovered circulating biomarkers miR-16 and miR-26a, which differentiate TTS from MI at presentation, were mechanistically involved in the pathophysiology of TTS.

Methods and results
miR-16 and miR-26a were co-overexpressed in rats with AAV and TTS induced with an adrenaline bolus. Untreated isolated rat cardiomyocytes were transfected with pre-/anti-miRs and functionally assessed. Ventricular basal hypercontraction and apical depression were accentuated in miR-transfected animals after induction of TTS. In vitro miR-16 and/or miR-26a overexpression in isolated apical (but not basal), cardiomyocytes produced strong depression of contraction, with loss of adrenaline sensitivity. They also enhanced the initial positive inotropic effect of adrenaline in basal cells. Decreased contractility after TTS-miRs was reproduced in non-failing human apical cardiomyocytes. Bioinformatic profiling of miR targets, followed by expression assays and functional experiments, identified reductions of CACNB1 (L-type calcium channel Cavβ subunit), RGS4 (regulator of G-protein signalling 4), and G-protein subunit Gβ (GNB1) as underlying these effects.

Conclusion
miR-16 and miR-26a sensitize the heart to TTS-like changes produced by adrenaline. Since these miRs have been associated with anxiety and depression, they could provide a mechanism whereby priming of the heart by previous stress causes an increased likelihood of TTS in the future.
Results of a prospective follow-up study after type A aortic dissection repair: a high rate of distal aneurysmal evolution and reinterventions
Authors: Gaudry Marine , Porto Alizée , Guivier-Curien Carine , Blanchard Arnaud , Bal Laurence , Resseguier Noemie , Omnes Virgile , De Masi Mariangela , Ejargue Meghann , Jacquier Alexis , Gariboldi Vlad , Deplano Valérie , Piquet Philippe 
Published: June 2021

Abstract

OBJECTIVES
We investigated the anatomical evolution of residual aortic dissection after type A repair and factors associated with poor prognosis at a high-volume aortic centre.

METHODS
Between 2017 and 2019, all type A aortic dissections were included for prospective follow-up. Patients without follow-up computed tomography (CT) scan available for radiological analysis and patients without residual aortic dissection were excluded from this study. The primary end point was a composite end point defined as dissection-related events including aneurysmal evolution (increased diameter &gt; 5 mm/year), aortic reintervention for malperfusion syndrome, aortic diameter &gt;55 mm, rapid aortic growth &gt;10 mm/year or aortic rupture and death. The secondary end points were risk factors for dissection-related events and reintervention analysis. All immediate and last postoperative CT scans were analysed.

RESULTS
Among 104 patients, after a mean follow-up of 20.4 months (8–41), the risk of dissection-related events was 46.1% (48/104) and the risk of distal reintervention was 17.3% (18/104). Marfan syndrome (P &lt; 0.01), aortic bicuspid valve (P = 0.038), innominate artery debranching (P = 0.025), short aortic cross-clamp time (P = 0.011), initial aortic diameter &gt;40 mm (P &lt; 0.01) and absence of resection of the primary entry tear (P = 0.015) were associated with an increased risk of dissection-related events or reintervention during follow-up.

CONCLUSIONS
Residual aortic dissection is a serious disease requiring close follow-up at an expert centre. This study shows higher reintervention and aneurysmal development rates than currently published. To improve long-term outcomes, the early demographic and anatomic poor prognostic factors identified may be used for more aggressive treatment at an early phase.
Effectiveness of the Wearable Sensor-based Ambient Intelligent Geriatric Management (AmbIGeM) System in Preventing Falls in Older People in Hospitals
Authors: Visvanathan Renuka , Ranasinghe Damith C , Lange Kylie , Wilson Anne , Dollard Joanne , Boyle Eileen , Jones Katherine , Chesser Michael , Ingram Katharine , Hoskins Stephen , Pham Clarabelle , Karnon Jonathan , Hill Keith D 
Published: June 2021

AbstractBackgroundThe Ambient Intelligent Geriatric Management (AmbIGeM) system augments best practice and involves a novel wearable sensor (accelerometer and gyroscope) worn by patients where the data captured by the sensor are interpreted by algorithms to trigger alerts on clinician handheld mobile devices when risk movements are detected.MethodsA 3-cluster stepped-wedge pragmatic trial investigating the effect on the primary outcome of falls rate and secondary outcome of injurious fall and proportion of fallers. Three wards across 2 states were included. Patients aged ≥65 years were eligible. Patients requiring palliative care were excluded. The trial was registered with the Australia and New Zealand Clinical Trials registry, number 12617000981325.ResultsA total of 4924 older patients were admitted to the study wards with 1076 excluded and 3240 (1995 control, 1245 intervention) enrolled. The median proportion of study duration with valid readings per patient was 49% ((interquartile range [IQR] 25%-67%)). There was no significant difference between intervention and control relating to the falls rate (adjusted rate ratio = 1.41, 95% confidence interval [0.85, 2.34]; p = .192), proportion of fallers (odds ratio = 1.54, 95% confidence interval [0.91, 2.61]; p = .105), and injurious falls rate (adjusted rate ratio = 0.90, 95% confidence interval [0.38, 2.14]; p = .807). In a post hoc analysis, falls and injurious falls rate were reduced in the Geriatric Evaluation and Management Unit wards when the intervention period was compared to the control period.ConclusionsThe AmbIGeM system did not reduce the rate of falls, rate of injurious falls, or proportion of fallers. There remains a case for further exploration and refinement of this technology given the post hoc analysis findings with the Geriatric Evaluation and Management Unit wards.Clinical Trials Registration Number: 12617000981325
Cognitive Reserve Moderates Associations Between Walking Performance Under Single- and Dual-Task Conditions and Incident Mobility Impairment in Older Adults
Authors: O’Brien Catherine , Holtzer Roee 
Published: June 2021

Abstract

Background
Among older adults, walking performance is a reliable indicator of adverse health outcomes including incident mobility impairment. Whereas, attention and executive functions have been implicated in cognitive control of locomotion, much less is known about the role of cognitive reserve (CR) in predicting mobility impairments among older adults. Specifically, whether CR moderates the relationship between gait performance and incident mobility impairment has not been reported. To address this gap in the literature, we examined whether gait performance under single-task walk (STW) and dual-task walk (DTW) conditions predicted incident mobility impairment and whether CR moderated this relationship.

Method
Participants were 176 (mean age = 75.57; % female = 53) older adults with baseline Short Physical Performance Battery (SPPB) scores of 10–12. Participants completed neuropsychological testing, the SPPB, and a DTW protocol. CR was evaluated using the Wide Range Achievement Test, third edition. Participants were followed for 3 years; individuals whose SPPB scores declined below 10 were defined as incident cases of mobility impairment (n = 42).

Results
Moderation analyses revealed significant interaction effects of CR with walking velocity under STW (b = 0.09, 95% CI [0.01, 0.17], z = 2.30, p = .02) and DTW (b = 0.10, 95% CI [0.02, 0.17], z = 2.55, p = .01) conditions, wherein slower gait predicted increased risk of incident mobility impairment among individuals with lower CR.

Conclusion
These findings extend knowledge about the interrelation of cognitive and mobility functions, revealing the critical role of CR in identifying older adults at risk of developing incident mobility impairment.
Midlife Vision Impairment and Cognitive Function in Later Life: The Study of Women’s Health Across the Nation, Michigan Cohort
Authors: Kolli Ajay , Hood Michelle M , Karvonen-Gutierrez Carrie , Moroi Sayoko E , Ehrlich Joshua R , Gillespie Brenda W , Dougherty Wood Sarah , Musch David C 
Published: June 2021

Abstract

Background
In older adults, vision impairment (VI) is associated with worse cognitive function. However, the relationship between midlife vision and future cognitive function remains unknown.

Methods
The Study of Women’s Health Across the Nation, Michigan site, is a longitudinal cohort of midlife women aged 42–52 years at baseline. Presenting Titmus visual acuity (VA) in the better-seeing eye was assessed at baseline and categorized as no or mild VI (VA ≥20/60), or moderate or worse VI (VA &lt;20/60). Cognitive function was measured 8 times over 15 years using the East Boston Memory Test immediate (EBMTi) and delayed (EBMTd) recall and the Digit Span Backwards (DSB) test. Linear mixed models with a random intercept and slope for age were constructed to detect associations between VI at baseline and future repeated measures of cognitive function, adjusting for age, race, education, financial strain, alcohol use, and tobacco use.

Results
About 394 women aged 42–52 at baseline with a maximum follow-up of 20 years were included in this analysis. After covariate adjustment, moderate or worse VI was associated with lower EMBTi (β = −0.56, p = .012), EBMTd (β = −0.60, p = .009), and DSB (β = −0.84, p = .04). While we detected significant associations between VI and levels of cognitive function scores, rates of cognitive decline as individuals aged did not vary by VI status.

Conclusion
Moderate or worse VI, assessed during midlife, was associated with lower scores on measures of cognitive function over a 15-year period during which women transitioned from midlife to older adulthood.
Associations Between Changes in Daily Behaviors and Self-Reported Feelings of Depression and Anxiety About the COVID-19 Pandemic Among Older Adults
Authors: Robbins Rebecca , Weaver Matthew D , Czeisler Mark É , Barger Laura K , Quan Stuart F , Czeisler Charles A 
Published: June 2021

Abstract

Objectives
Due to the significant mortality and morbidity consequences of the coronavirus disease 2019 (COVID-19) pandemic among older adults, these individuals were urged to avoid going out in public and socializing with others, among other major disruptions to daily life. While these significant and often unavoidable disruptions have been shown to bear consequences for mental health, less attention has been devoted to behavioral changes, such as changes to sleeping or eating due to the COVID-19 pandemic, and their implications for emotional well-being.

Methods
We utilized data from a nationally representative survey of Medicare beneficiaries (aged 65 and older), which was administered between June and October 2020 (n = 3,122). We examine the relationship between self-reported changes to daily behaviors (e.g., sleep, drinking alcohol, and exercise) and emotional impacts of the COVID-19 pandemic (i.e., feelings of depression and anxiety about the COVID-19 pandemic) using stepwise hierarchical multivariable Poisson regression.

Results
We found that worse sleep quality, sleeping more or less, watching more television, and walking less were associated with more feelings of depression and anxiety about the COVID-19 pandemic.

Discussion
Previous research has shown a connection between the significant and often unavoidable disruptions to daily life due to the COVID-19 pandemic (e.g., sheltering in place) and adverse mental health symptoms. Less attention has been paid to potentially modifiable behaviors, such as sleep and exercise. Our findings highlight the behavioral changes associated with adverse emotional impacts among older adults during the COVID-19 pandemic. Future research may evaluate whether behavioral interventions may aim to attenuate the impact of pandemics on daily, modifiable behaviors to buffer against adverse emotional impacts.
The COVID-19 Pandemic Introduces Diagnostic and Treatment Planning Complexity for Individuals at Clinical High Risk for Psychosis
Authors: Mittal Vijay A , Walker Elaine F , Strauss Gregory P 
Published: June 2021

Abstract
COVID-19 has led to a great deal of general suffering and an increased prevalence of psychiatric illness worldwide. Within the area of psychosis-risk syndromes, a highly heterogeneous clinical population, the picture is quite nuanced as the social restrictions resulting from the pandemic have reduced stress for some and increased it for others. Further, a number of pandemic-related societal and cultural changes have obfuscated the diagnostic and treatment landscape in this area as well. In this opinion article, we describe several prototypical cases, representative of presentations seen in our clinical high-risk (CHR) research programs. The cases highlight considerable clinical variability and, in addition, speak to the current complexities faced by diagnosticians and treatment providers. In addition to discussing these issues, this piece introduces potential solutions highlighting the promise of incorporating data-driven strategies to identify more homogenous CHR subtypes and employ precision medicine.
Functional Characterization of Gene Regulatory Elements
Authors: Ahituv Nadav 
Published: June 2021

Nucleotide variation in gene regulatory elements is a major determinant of phenotypes including morphological diversity between species, human variation and human disease. Despite continual progress in the cataloging of these elements, little is known about the code and grammatical rules that govern their function. Deciphering the code and their grammatical rules will enable high‐resolution mapping of regulatory elements, accurate interpretation of nucleotide variation within them and the design of sequences that can deliver molecules for therapeutic purposes. To this end, we are using massively parallel reporter assays (MPRAs) to simultaneously test the activity of thousands of gene regulatory elements in parallel. By designing MPRAs to learn regulatory grammar or to carry out saturation mutagenesis of every possible nucleotide change in disease causing gene regulatory elements, we are increasing our understanding of the phenotypic consequences of gene regulatory mutations. To better understand how nucleotide changes in gene regulatory elements lead to morphological differences between species, we are using the developing bat wing as a model. Using a combination of whole‐genome sequencing, RNA‐seq and ChIP‐seq (H3K27ac, H3K27me3) on developing bat and mouse forelimbs and hindlimbs at three sequential embryonic stages, we are attempting to decipher the molecular events that underlie bat wing development.Support or Funding InformationNICHD, NCI, NHGRI, NIMH, NHLBIThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Complete Regeneration of a Camera‐type Eye in the Research Organism Pomacea canaliculata
Authors: Accorsi Alice , Ross Eric , McClain Melainia , McKinney Sean , Alvarado Alejandro Sánchez 
Published: June 2021

The vertebrate single‐chambered camera eye is comprised of a cornea, an iris, a lens, a retina and an optic nerve. Although their sensitivity and image resolution are astonishing, their regenerative capacities are either limited or absent. A few amphibians and fishes are able to repair specific ablations of the cornea, lens or retina through the activation of cells in the ciliary marginal zone, but complete regeneration of their eyes after full removal has not been observed. Histological staining, electron microscopy and transcriptome analyses indicate that the camera‐type eyes of the freshwater snail Pomacea canaliculata (Gastropoda, Ampullariidae) are not only anatomically comparable to vertebrate eyes, but also able to regenerate de novo after complete amputation. Applying the same techniques to study embryonic eye development in P. canaliculata revealed a striking similarity between adult eye regeneration and embryonic eye development, particularly in terms of main morphological steps required for building a new eye and the timing required for developing and differentiating every component. While we are far from being able to state whether eye regeneration recapitulates embryonic eye development, our ability to culture embryos will allow us to formally compare embryonic and post‐embryonic processes such as regeneration to each other. In sum, an important set of tools have been developed to interrogate P. canaliculata biology and spur the establishment of genome editing and gene function perturbation technologies in this research organism.(Reported investigations have been conducted in conformance with the FASEB Statement of Principles for the use of Animals in Research and Education.)Support or Funding InformationAlice Accorsi is American Association of Anatomists Scholar and Society of Developmental Biology member and this research was in part funded by both the American Association of Anatomists and the Society of Developmental Biology. This research was also funded by Howard Hughes Medical Institute and Stowers Institute for Medical Research.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.