bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circ-Calm4 Regulates Hypoxia-Induced Pulmonary Artery Smooth Muscle Autophagy by Binding Purb
Authors: Zhang Junting , Li Yiying , Chen Yujie , Yu Xiufeng , Sun Hanliang , Zheng Xiaodong , Zhang Lixin , Wang Yifan , Zhu Daling 
Published: October 2021

Abstract
Pulmonary hypertension (PH) is a serious and fatal disease characterized by pulmonary vasoconstriction and pulmonary vascular remodeling. The excessive autophagy of pulmonary artery smooth muscle cells (PASMCs) is one of the important factors of pulmonary vascular remodeling. A number of studies have shown that circular RNA (circRNA) can participate in the onset of PH. Our previous studies have shown that circRNA calmodulin 4 (circ-calm4) is involved in the progression of hypoxic PH. However, the role of circ-calm4 on regulation of hypoxic PH autophagy has not been reported. In this study, we demonstrated for the first time that hypoxia-mediated upregulated circ-calm4 expression has a key regulatory effect on autophagy in hypoxia-induced PASMCs and hypoxic PH mouse models. Knockdown of circ-calm4 both in vivo and in vitro can inhibit the autophagy in PASMCs induced by hypoxia. We also performed bioinformatics predictions and conducted experiments to verify that circ-calm4 bound to the purine-rich binding protein (Purb) to promote its expression in the nucleus, thereby initiating the transcription of autophagy-related protein Beclin1. Interestingly, we found that Beclin1 transcription initiated by Purb was accompanied by a modification of Beclin1 super-enhancer to improve transcription activity and efficiency. Overall, our results confirm that the circ-calm4/Purb/Beclin1 signal axis is involved in the occurrence of hypoxia-induced PASMCs autophagy, and the novel regulatory mechanisms and signals transduction pathways in PASMC autophagy induced by hypoxia.
Single-Cell Transcriptomics Reveals Tissue Architecture in Ovarian Carcinosarcoma
Authors: Xu Junfen , Cen Yixuan , Lu Weiguo 
Published: October 2021

Abstract

Background
Ovarian carcinosarcoma (OCS) is one of rarest and most challenging histologic subtype of ovarian cancer. It features remarkable cellular heterogeneity. Using single-cell RNA sequencing, we characterize the cellular composition of the OCS and identify their molecular characteristics.
Methods
we applied single-cell RNA sequencing (scRNA-seq) to resected primary OCS for the in-depth analysis of tumor cells and the TME. Immunohistochemistry (IHC) staining was used for validation.
Results
Malignant epithelial and fibroblast cells displayed a high-degree of intratumoral heterogeneity. We revealed that certain epithelial cell subclusters had high levels of drug resistance scores and many active metabolic pathways. Furthermore, γδ T cells exhibited enriched IFNγ and IFNα response characteristics. Notably, we observed that macrophages were mainly M2-like macrophages with immunosuppressive properties. In addition, we found that the CD1A+/FCER1A+ DC cells were enriched with genes related to cytolytic effector pathway. Analyzing ligand-receptor interaction pairs between cell types, we identified broadly interacting cells and observed an interaction between the ANXA1+ epithelial population and FPR1+/FPR3+ myeloid cells.
Conclusion
Our findings provide a comprehensive single-cell transcriptomic landscape of human OCS and present a well-established resource for elucidating OCS diversity.
The Identification of MiRNA and MRNA Expression Profiles Associated with Pediatric Atypical Teratoid/rhabdoid Tumor
Authors: Xu Xinke , Yuan Hongyao , Pan Junping , Chen Wei , Chen Cheng , Li Yang , Li Fangcheng 
Published: October 2021

Abstract
Background: Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant pediatric tumor of the central nervous system (CNS) with high recurrence and low survival rates that is often misdiagnosed. MicroRNAs (miRNAs) are involved in the tumorigenesis of numerous pediatric cancers, but their roles in AT/RT remain unclear.Methods: In this study, we used miRNA sequencing and gene expression microarrays from patient tissue to study both the miRNAome and transcriptome traits of AT/RT.Results: Our findings demonstrate that 5 miRNAs were up-regulated, 16 miRNAs were down-regulated, 179 mRNAs were up-regulated and 402 mRNAs were down-regulated in AT/RT. The expressions of hsa-miR-17-5p and MAP7 mRNA showed the most significant differences in AT/RT tissues as assayed by qPCR, and analyses using the miRTarBase database identified MAP7 mRNA as a target gene of hsa-miR-17-5p. Conclusions: Our findings suggest that the dysregulation of hsa-miR-17-5p may be a pivotal event in AT/RT and MAP7 miRNAs that may represent potential therapeutic targets and diagnostic biomarkers.
Association of PM2.5 and Its Components With Lengths of Hospital Stay for Hand Foot and Mouth Disease in Children
Authors: Li Wei , Wang Jieguo , Zhou Kai , Tian Ye , Wei Feiran , Zhang Mingzhi , Wang Xu 
Published: October 2021

Abstract
Background

Hand foot and mouth disease (HFMD) is a public health concern. Studies on air pollution and the lengths of hospital stay (LOS) of HFMD are scarce.
Methods

We characterized the clinic demographic features of 5135 hospitalized HFMD in Nanjing, China from 2012 to 2017, and analyzed the association between short-term exposure to PM2.5 as well as its components (OM, BC, SO42−, NH4+, NIT, SOIL and SS) and the LOS of HFMD.
Results

Among them 98.62% were aged 0–6 years old, and 3772 (73.46%) were hospitalized for seven days or less. The LOS of HFMD children was different in different ages, illness onset years and illness onset seasons (P<0.01). For per IQR increase in PM2.5 concentrations, LOS of HFMD increased by 0.52(0.33, 0.71), 0.50 (95% CI, 0.31–0.69) and 0.46 (95% CI, 0.28–0.65) day in adjusted models at lag 3 days, lag 7days and lag 14 days, respectively. In addition, per IQR increase of BC, SO42−, NH4+, NIT and SOIL were also significantly associated with the LOS of HFMD.
Conclusions

Our findings corroborated the hypothesis that short-term PM2.5 exposure was associated with increased the LOS of HFMD, and its components (BC, SO42−, NH4+, NIT and SOIL) of PM2.5 might play a key role in the prolonged LOS of HFMD.
Energy Optimization in Smart Urban Buildings Using Bio-Inspired Ant Colony Optimization
Authors: Khan Fakhri Alam , Ullah Kifayat , Rahman Atta ur , Anwar Sajid 
Published: October 2021

Abstract
Instead of planting new electricity generation units, there is a need to design an efficient energy management system to achieve a normalized trend of power consumption. Smart grid has been evolved as a solution, where Demand Response (DR) strategy is used to modify the nature of demand of consumer. In return, utility pay incentives to the consumer. The increasing load demand in residential area and irregular electricity load profile have encouraged us to propose an efficient Home Energy Management System (HEMS) for optimal scheduling of home appliances. In order to meet the electricity demand of the consumers, the energy consumption pattern of a consumer is maintained through scheduling the appliances in day-ahead and real-time bases. In this paper we propose a hybrid algorithm Bacterial foraging Ant colony optimization is proposed (HB-ACO) which contain both BFA and ACO properties. Primary objectives of scheduling is to shift load from On-peak hour to Off-peak hours to reduce electricity cost and peak to average ratio. A comparison of these algorithms is also presented in terms of performance parameters electricity cost, reduction of PAR and user comfort in term of waiting time. The proposed techniques are evaluated using two pricing scheme time of use and critical peak pricing. The HB-ACO shows better performance as compared to ACO and BFA which is evident from the simulation results
Moreover the concept of coordination among home appliances is presented for real time scheduling. We consider this is knapsack problem and solve it through Ant colony optimization algorithm.
Elastomeric Seal Stress Analysis Using Photoelastic Experimental Hybrid Method
Authors: Mose Bruno , Shin Dong-Kil , Alunda Bernard , Nam Jeong-Hwan 
Published: October 2021

Abstract
Stress freezing is an important and powerful procedure in 3-dimensional experimental stress analysis using photoelasticity. The application of the stress freezing technique to extract stress components from loaded engineering structures has, however, declined over the years even though its principles are well established. This is attributed to huge costs arising from energy consumption during the process. In addition, significant time is needed to generate the desired information from isoclinic and isochromatic fringes. To overcome the limitations of stress freezing in photoelasticity and transform it into an economical device for stress analysis in an engineering environment, a new stress freezing cycle that lasts 5 hours is proposed. The proposed technique is used in several applications of elastomeric seals with different cross-sectional profiles to assess its suitability. It was found that reducing the cycle time can lead to huge energy savings without compromising the quality of the fringes. Moreover, the use of isochromatic only to extract stress components leads to a shorter processing time to achieve desirable information since the process of obtaining isoclinic data is involving. In this paper, results of stress analysis from stress frozen elastomeric seals with various cross-sections using the new stress freezing cycle are presented.
Effects of perioperative red blood cell transfusion on systemic immune indicators and postoperative recovery in patients undergoing cesarean section: A propensity score matching analysis
Authors: Zhou Yilu , Tao Yiyi , Xu Zhendong , Liu Zhiqiang 
Published: October 2021

Abstract
Background

Postpartum hemorrhage (PPH) is one of the leading causes of maternal death in all regions of the world. Intra-operative red blood cell transfusion is one of the most effective strategies to treat PPH. However, the effect of blood transfusion on patients undergoing cesarean section remains unclear. The aim of this study was to investigate the effects of a intra-operative blood transfusion on systemic immune indicators and postoperative recovery in patients undergoing cesarean section.
Methods

This retrospective study enrolled patients undergoing cesarean section between January 2016 and June 2020. We divided these patients into two groups according to whether they received a intraoperative blood transfusion. Baseline characteristics were compared between groups. After propensity score matching, the length of stay (LOS), perioperative systemic inflammation-based scores, and postoperative complications were compared. Univariate and multivariable Cox proportional hazard models were used to evaluate the associations between covariates and outcomes.
Results

A total of 1221 patients were enrolled. After propensity score matching, a significant difference in LOS was observed between groups (4.2days vs. 6.6days, P=0.026). The postoperative complication rate in the blood transfusion (BT) group was significantly higher than that in the non-blood transfusion(NBT) group (vomiting, 3.2% vs. 4.9%, P=0.032; fever, 5.41% vs. 2.24%, P=0.032; wound complications, 15.44% vs. 10.45%, P=0.028; intestinal obstructions, 5.88% vs. 2.75%, P=0.034, respectively). The systemic inflammatory indicators fluctuated significantly in the BT group compared with the NBT group on POD1 and POD3. The multivariate analysis indicated that intra-operative blood transfusion was associated with a longer LOS (hazard ratio: 1.52, 95% confidence interval: 1.07, 2.25).
Conclusions

A intra-operative blood transfusion was associated with fluctuations in systemic inflammatory indicators, higher postoperative complication rates and a prolonged length of stay.
Association between LDL-C/HDL-C Ratio and Carotid Atherosclerosis in an Asymptomatic Japanese Population: A Cross-Sectional Study
Authors: Wang Juan , Liu Jiuling 
Published: October 2021

Abstract
Background and aims

LDL-C/HDL-C ratio predicted atherosclerosis progression better than LDL-C or HDL-C alone. However, the association between LDL-C/HDL-C ratio and Carotid Atherosclerosis(CA) is still controversial. There is a lack of research on this topic in theAsymptomatic Japanese Population. This study aims to provide further results.

Methods

The study population was a cross-sectional study of 1904 subjects free of cardio-cerebrovascular disease at baseline(mean age 57±11.9 years, 51.9% male). All participant sultrasonography of the carotid artery. The presence of carotid plaque score(PS) aand plaque number (PN) were evaluated by ultrasonography. Multivariate logistic regression models to estimatethe LDL-C/HDL-C ratio and PS relationship. Participants were stratified into three groups based on LDL-C/HDL-C ratio tertiles. Interaction and stratified analyses were conductedaccording to age, sex, smoking status, drinking status, fatty, and histories of diabetes.

Results

In regression models and after multiple adjustments, the risk of PS was significantly associated with serum LDL-C/HDL-C ratio levels in which LDL-C/HDL-C ratio was included as a categorical variable. It remained significant for the highest vs the first tertile of the LDL-C/HDL-C ratio (OR=1.50, 95% CI 1.04–2.17). Stratified analysis,we found that the association was more significant aged <65 years old, female and non-diabetes subgroups.Interaction analysis showed no interaction between LDL-C/HDL-C ratio and PS in the fatty,smoking, and drinking subgroups.

Conclusions

In conclusion, LDL-C/HDL-C ratio is an independent risk factor for CA in the Japanese population. A prospective and randomized clinical trial of LDL-C/HDL-C ratio lowering therapy in the Japanese population is needed to assess the causal nature of the relationship.
Identification and Evolutionary Characterization of Papillomavirus Sequences in New World Monkeys (Genera Sapajus and Alouatta) from Argentina
Authors: Fernandez Candelaria Sanchez , Bolatti Elisa M , Culasso Andres C.A. , Chouhy Diego , Kowalewski Martin M , Stella Ema J , Schurr Theodore G , Rinas Miguel A , Liotta Domingo Javier , Campos Rodolfo H. , Giri Adriana A , Badano Ines 
Published: October 2021

Abstract
Objective: In this study, we investigated the occurrence of papillomavirus (PV) infection in non-human primates (NHP, Platyrrhine) of northeastern Argentina by using broad-spectrum PCR primers at the L1 gene. In addition, we conducted a phylogenetic and coalescence analysis of viral sequences to explore their evolutionary history and evaluate the co-speciation hypothesis in the context of primate evolution. Methods: We obtained samples of 57 individuals from wild and captive populations of Alouatta caraya, Sapajus nigritus and Sapajus cay. We assessed PV infection by PCR amplification with the CUT primer system and sequencing of 337 bp (112 amino acids) of the L1 protein. The viral sequences were analyzed by phylogenetic and Bayesian coalescence methods to estimate the age of the most common recent ancestor (tMCRA) with BEAST, v1.4.8 software. We evaluated viral/host tree congruence with TreeMap v3.0. Results: We identified two novel putative PV sequences of the genus Gamma- PV in Sapajus sp and Alouatta caraya (SPV1 and AcPV1, respectively). The tMRCA of SPV1 was estimated at 11,941,682 years before present (ybp) and that of AcPV1 at 46,638,071 ybp, both predating the coalescence times of their hosts: 6.4 million years (MYA) and 6.8 MYA, respectively. Based on the comparison of primate and viral phylogenies, we could not reject the null hypothesis that the PV tree is no more congruent with the host tree than a random tree would be (P>0.05). Thus, a model of virus-host coevolution was rejected. Conclusion: This study presents the first report of PV infection in Platyrrhine species from Argentina, expands the range of described hosts for these viruses, and proposes new scenarios for their origin and dispersal.
Development of SOM Daily Precipitation Statistical Downscaling Model And Its Applicability Assessment in North China
Authors: Wang Yongdi , Sun Xinyu 
Published: October 2021

Abstract
A statistical downscaling method based on SOM which named SOM-SD is used over North China. It’s applicatibility by downscaling daily precipitation is evaluated. Indices are selected which represent the statistics of daily precipitation with regard to both precipitation amount (Prtot, SDII) and frequency (nr001), as well as extreme event (P95T, CWD, CDD). The large-scale predictors were extracted from the daily NCEP reanalysis data, while the predictand was high resolution gridded daily observed precipitation. A downscaling method based on SOM named SOM-SD was presented and evaluated. In evaluating, the frequency difference of wet-dry nodes is defined. And it is confirmed that there was a significant positive correlation between frequency difference and precipitation. The SOM-SD method displayed a high skill in reproducting the climatologic statistical properties of the observed precipitation. The value of BS is between 0 and 1.5×10-4. Sscore is between 0.8 and 1. The bias ranges are -7.4% and -11.6% for Prtot and SDII, -3.1days for nr001, +3.4% for P95T, -1.1 days for CWD and +3.5 days for CDD. Therefore, SOM-SD method works reasonably well.
A Novel Spatiotemporal Trajectory Pattern Recognition with Nature Inspired Early Destination Prediction Algorithm Using Intelligent Sensor Devices for Secure Wireless Communication
Authors: Prabhakaran D. , Jesudas T. 
Published: October 2021

Abstract
This research work focused mainly on early prediction of destination and emergency-oriented procedure to recognize trajectory patterns from intelligent sensor devices by analyzing GPS data. As an option in contrast to the customary two essential methodologies with direction following that limit the hopefuls regarding the excursion advance, and Next Place Prediction that surmises the future area of a client from client propensities, we proposed here another model dependent on both ordinary models. The benefit of this research work is, it definitely limits the goal hopefuls productively at the beginning time of a trek, inferable from the staying data got from the NPP approach. In spite of the straightforwardness of our model, the proposed strategy gives enhanced execution contrasted with traditional methodologies dependent on the test results utilizing the GPS logs of 1,546 genuine clients from the business administrations. To assess the proposed strategy and techniques, consecutive direction informational indexes originate from the GeoLife venture alongside human circulation logs from cell phone application EMAPP are used. Goal expectation (e.g., anticipating a future area) can be connected to different down to earth applications. A case of goal expectation is customized GIS administrations, which are relied upon to give backup courses of action to empower clients to maintain a strategic distance from clogged streets in future applications. At long last, we show the capability of managing area data for advancing crisis the executives.
Binge Eating Disorder, Depression and Anxiety, and Weight Gain and Increased BMI After Five Years of Bariatric Surgery
Authors: Delfino Heitor Bernardes Pereira , Pinhel Marcela Augusta Souza , Ferreira Flávia Campos , Nicoletti Carolina Ferreira , Oliveira Sofia Teixeira Prates , Baumgartner Lidia Barbieri Belrmino , Welendorf Caroline Rossi , Malek-Zadeh Carolina Hunger , Junior Wilson Salgado , Nonino Carla Barbosa 
Published: October 2021

Abstract
ObjectivesAnalyze the influence of Binge Eating Disorder (BED) and symptoms of depression and anxiety on anthropometric and body composition changes over five years after bariatric surgery in patients with obesity.MethodsEvaluation of 118 individuals undergoing bariatric surgery, divided into two groups: Group 1: individuals with BED; Group 2: individuals without BED. The individuals were submitted to anthropometric and body composition evaluation, and analysis of the presence of BED, depression, and anxiety according to the DSM-V and using validated questionnaires. The Kolmogorovi-Smirnov, t-test, Fisher’s, chi-square, and ANOVA were used for statistical analysis.ResultsThe groups with BED (N=61, 51,7%) and without BED (N=57, 48,3%) did not differ from each other for all sociodemographic assessed variables (p>0.05) and had similar changes in waist circumference and body composition over five years after bariatric surgery (p>0.05). On the other hand, only patients with BED had severe depression (13,11%, p=0.0079) and had a higher frequency of moderate (22.95%, p=0.0022) and severe (14.75%, p=0.0022) anxiety in the preoperative period of bariatric surgery. In addition, only the group with BED had increased weight and increased BMI in the fifth year after bariatric surgery (p<0.05).ConclusionPatients with BED had more intense symptoms of depression and anxiety, and this disorder may reappear in the postoperative period of bariatric surgery and contribute to weight gain and an increase in BMI.Level of evidence: III (evidence obtained from case-control analytic study).
Discopersicus hexagrammatus n. sp. (Rhabditida: Tylenchidae), the second species of the genus
Authors: Hosseinvand Manouchehr , Eskandari Ali , Abolafia Joaquín , Ghaderi Reza 
Published: October 2021

Abstract
Discopersicus hexagrammatus n. sp., is described and illustrated from a population associated with the rhizosphere of carrot (Daucus carota L.) in Dezful, Khuzestan province, south-western Iran. Based on morphological and morphometric data, the new species is characterized by a 601-734 µm long body, a prominent perioral labial disc and oblique amphidial slits, 10-11 µm long stylet, vulva at 65-67% of body length, 15.5-17 µm long spicules, and an elongate conoid tail with a pointed terminus. It is the second species of the genus Discopersicus and differs from its counterpart D. iranicus, by its anterior position of vulva, shorter stylet, lower M.B. ratio, different shape of tail tip, and shorter spicules in male specimens. A molecular phylogenetic analysis using the D2-D3 expansion segments of 28S rDNA sequences, placed the new species in close relationship with five sequences of the genus Boleodorus.
The impact of the water commonweal propaganda on citizens' water-saving behavior: the intermediary role of propaganda channels and forms – evidence from China
Authors: Zhang Shujing , Fu Hao , Wang Yanrong 
Published: October 2021

Abstract
The water commonweal propaganda is an important measure to promote citizens’ water resource conservation and water-saving behavior. Based on Amos 21.0, this paper adopts structural equation models, through variable extraction and path construction, to explore the mechanisms of how water commonweal propaganda influences citizens' water-saving behavior. The research investigates the case of China's water commonweal propaganda. The results show that: (1) when the same propaganda forms and channels are adopted, the impact of different water commonweal propaganda content on citizens' water-saving behavior is significantly different; (2) with the same water commonweal propaganda content, different propaganda forms and channels have different impacts on citizens' water-saving behavior. Therefore, selecting appropriate propaganda forms and channels for the water commonweal propaganda can significantly improve their impact on citizens' water-saving behaviors. The research aims to provide theoretical support and practical basis for China's follow-up water commonweal propaganda.
Henri Roorda : le charme d’un suicide
Authors: Von Dach Yla 
Published: October 2021

Les différentes possibilités qui s’offrent à la traduction en allemand du titre Mon suicide ouvrent non seulement sur une exploration de ce qui caractérise l’approche de Henri Roorda dans sa critique de la société, mais également sur une réflexion quant aux façons de nommer ou de ne pas nommer les choses et aux implications de la tendance actuelle à éviter “d’appeler les choses par leur nom”, de peur de heurter les sensibilités.
Keywords : Henri Roorda, traduction, suicide, allemand, nuances de sens, franc-parler, langage voilé.