bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective denervation of the corrugator supercilii muscle for the treatment of idiopatic trigeminal neuralgia purely paroxysmal distributed in the supraorbital and suprathrochlear dermatomes
Authors: Gualdi Alessandro , Cambiaso-Daniel Janos , Gatti Jonatann , Peled Ziv M. , Hagan Robert , Bertossi Dario , Wurzer Paul , Kamolz Lars-Peter , Scherer Saja , Pietramaggiori Giorgio 
Published: March 2021

Abstract
Introduction
Idiopatic trigeminal neuralgia purely paroxysmal (ITNp) distributed in the supraorbital and suprathrochlear dermatomes (SSd), refractory to conventional treatments have been linked to the hyperactivity of the corrugator supercilii muscle (CSM). In these patients, the inactivation of the CSM via botulinum toxin type A (BTA) injections has been proven to be safe and effective in reducing migraine burden. The main limitation of BTA is the need of repetitive injections and relative high costs. Based on the study of the motor innervation of the CSM, we describe here an alternative approach to improve these type of migraines, based on a minimally invasive denervation of the CSM.

Materials and methods
Motor innervation and feasibility of selective CSM denervation was first studied on fresh frozen cadavers. Once the technique was safely established, 15 patients were enrolled. To be considered eligible, patients had to meet the following criteria: positive response to BTA treatment, migraine disability assessment score > 24, > 15 migraine days/month, no occipital/temporal trigger points and plausible reasons to discontinue BTA treatment. Pre- and post- operative migraine headache index (MHI) were compared, and complications were classified following the Clavien-Dindo classification (CDC).

Results
Fifteen patients (9 females and 6 males) underwent the described surgical procedure. The mean age was 41 ± 10 years. Migraine headache episodes decreased from 24 ± 4 day/month to 2 ± 2 (p < 0.001) The MHI decreased from 208 ± 35 to 10 ± 11 (p < 0.001). One patient (7%) had a grade I complication according to the CDC. No patient needed a second operative procedure.

Conclusions
Our findings suggest that the selective CSM denervation represents a safe and minimally invasive approach to improve ITNp distributed in the SSd associated with CSM hyperactivation.

Trial registration
The data collection was conducted as a retrospective quality assessment study and all procedures were performed in accordance with the ethical standards of the national research committee and the 1964 Helsinki Declaration and its later amendments.
OryzaGenome2.1: Database of Diverse Genotypes in Wild Oryza Species
Authors: Kajiya-Kanegae Hiromi , Ohyanagi Hajime , Ebata Toshinobu , Tanizawa Yasuhiro , Onogi Akio , Sawada Yuji , Hirai Masami Yokota , Wang Zi-Xuan , Han Bin , Toyoda Atsushi , Fujiyama Asao , Iwata Hiroyoshi , Tsuda Katsutoshi , Suzuki Toshiya , Nosaka-Takahashi Misuzu , Nonomura Ken-ichi , Nakamura Yasukazu , Kawamoto Shoko , Kurata Nori , Sato Yutaka 
Published: March 2021

Abstract
Background
OryzaGenome (http://viewer.shigen.info/oryzagenome21detail/index.xhtml), a feature within Oryzabase (https://shigen.nig.ac.jp/rice/oryzabase/), is a genomic database for wild Oryza species that provides comparative and evolutionary genomics approaches for the rice research community.

Results
Here we release OryzaGenome2.1, the first major update of OryzaGenome. The main feature in this version is the inclusion of newly sequenced genotypes and their meta-information, giving a total of 217 accessions of 19 wild Oryza species (O. rufipogon, O. barthii, O. longistaminata, O. meridionalis, O. glumaepatula, O. punctata, O. minuta, O. officinalis, O. rhizomatis, O. eichingeri, O. latifolia, O. alta, O. grandiglumis, O. australiensis, O. brachyantha, O. granulata, O. meyeriana, O. ridleyi, and O. longiglumis). These 19 wild species belong to 9 genome types (AA, BB, CC, BBCC, CCDD, EE, FF, GG, and HHJJ), representing wide genomic diversity in the genus. Using the genotype information, we analyzed the genome diversity of Oryza species. Other features of OryzaGenome facilitate the use of information on single nucleotide polymorphisms (SNPs) between O. sativa and its wild progenitor O. rufipogon in rice research, including breeding as well as basic science. For example, we provide Variant Call Format (VCF) files for genome-wide SNPs of 33 O. rufipogon accessions against the O. sativa reference genome, IRGSP1.0. In addition, we provide a new SNP Effect Table function, allowing users to identify SNPs or small insertion/deletion polymorphisms in the 33 O. rufipogon accessions and to search for the effect of these polymorphisms on protein function if they reside in the coding region (e.g., are missense or nonsense mutations). Furthermore, the SNP Viewer for 446 O. rufipogon accessions was updated by implementing new tracks for possible selective sweep regions and highly mutated regions that were potentially exposed to selective pressures during the process of domestication.

Conclusion
OryzaGenome2.1 focuses on comparative genomic analysis of diverse wild Oryza accessions collected around the world and on the development of resources to speed up the identification of critical trait-related genes, especially from O. rufipogon. It aims to promote the use of genotype information from wild accessions in rice breeding and potential future crop improvements. Diverse genotypes will be a key resource for evolutionary studies in Oryza, including polyploid biology.
Pain in adult myotonic dystrophy type 1: relation to function and gender
Authors: Solbakken Gro , Løseth Sissel , Froholdt Anne , Eikeland Torunn D. , Nærland Terje , Frich Jan C. , Dietrichs Espen , Ørstavik Kristin 
Published: March 2021

AbstractBackgroundPain is prevalent in myotonic dystrophy 1 (DM1). This study investigated whether CTG repeat size, disease duration, BMI and motor and psychological function were related to pain in adult patients with DM1, and if there were gender differences regarding intensity and location of pain.MethodCross-sectional design. Pain was investigated in 50 genetically confirmed DM1 patients by combining clinical assessment and self-reports of pain intensity and locations. Pain scoring results were related to CTG size, disease duration, muscle strength, walking capacity measured by 6-min walk test, activity of daily life by Katz ADL Index, respiratory function by Forced Vital Capacity and BMI. In addition, the degree of reported pain was related to Quality of life measured by WHOQOL-BREF; fatigue was measured by Fatigue severity scale; psychological functions were measured by Beck Depression Inventory, Beck Anxiety Inventory, IQ and Autism spectrum Quotient.ResultsPain was reported in 84% of the patients and was significantly correlated with CTG size (r = 0.28p = 0.050), disease duration (r = 0.38p = 0.007), quality of life (r = − 0.37p = 0.009), fatigue (r = 0.33p = 0.02) and forced vital capacity (r = − 0.51,p = 0.005). Significant gender differences, with higher scores for females, were documented. In male subjects the number of pain locations was significantly correlated with quality of life and the autism quotient. In females, pain intensity was significantly correlated with activity, respiratory function and BMI.ConclusionsPain in DM1 was prevalent, with a strong association to lung function and other aspects of the disease. Significant gender differences were present for pain intensity and number of pain locations. How pain was related to other symptoms differed between male and female subjects. Our findings highlight the importance of assessments of pain in DM1 patients.
A surrogate measure for patient reported symptom remission in administrative data
Authors: Alemi Farrokh , Aljuaid Mai , Durbha Naren , Yousefi Melanie , Min Hua , Sylvia Louisa G. , Nierenberg Andrew A. 
Published: March 2021

Abstract
Background
In real-world pragmatic administrative databases, patient reported remission is often missing.

Objective
We evaluate if, in administrative data, five features of antidepressant use patterns can replace patient-reported symptom remission.

Method
We re-examined data from Sequence Treatment Alternatives to Relieve Depression (STAR*D) study. Remission was measured using 50% reduction in Hamilton index. Pattern of antidepressant use was examined through five variables: (a) number of prior ineffective antidepressants, (b) duration of taking current antidepressant, (c) receiving therapeutic dose of the medication, and (d) switching to another medication, or (e) augmenting with another antidepressant. The likelihood ratio (LR) associated with each of these predictors was assessed in 90% of data (3329 cases) and evaluated in 10% of data (350 cases) set-aside for evaluation. The accuracy of predictions was calculated using Area under the Receiver Operating Curve (AROC).

Results
Patients who took antidepressants for 14 weeks (LR = 2.007) were more likely to have symptom remission. Prior use of 3 antidepressants reduced the odds of remission (LR = 0.771). Patients who received antidepressants below therapeutic dose were 5 times less likely to experience remission (LR = 0.204). Antidepressant that were augment or switched, almost never led to remission (LR = 0.008, LR = 0.002 respectively). Patterns of antidepressant use accurately (AROC = 0.93) predicted symptom remission.

Conclusion
Within the first 100 days, antidepressants use patterns could serve as a surrogate measure for patient-reported remission of symptoms.
The psychometric properties of the Bergen–Yale sex addiction scale for the Iranian population
Authors: Youseflu Samaneh , Kraus Shane W. , Razavinia Fatemeh , Afrashteh Majid Yousefi , Niroomand Soudabeh 
Published: March 2021

Abstract
Background
The assessment of sex addiction among different populations requires a valid and reliable tool. Since the Bergen–Yale Sex Addiction Scale (BYSAS) was not available in Iran, this study aimed to evaluate the validity and reliability of the Persian version of the BYSAS.

Methods
After translation/back-translation procedure, a total of 756 Iranian men and women completed the BYSAS. The structural validity of this tool was evaluated by exploratory and confirmatory factor analyses. An expert panel review also examined content validity of the items. Psychometric properties of the scale including validity, reliability (internal consistency [Cronbach’s alpha]) and test-retest) and factor structure were assessed.

Results
Content Validity Index (CVI) and Content Validity Ratio (CVR) scores for the BYSAS were 0.75 and 0.62, respectively. In the measure’s structural validity, the results of exploratory and confirmatory factor analysis supported the One-factor structure. Data analysis demonstrated satisfactory internal consistency (Cronbach’s alpha ranging from 0.88 to 0.89).

Discussion
Study findings suggest that the BYSAS is a valid and reliable instrument for assessing sex addiction among Persian speaking adults. Replication of research findings is needed to expand the BYSAS for clinical and non-clinical Iranian populations.
Characterization of multidrug-resistant Acinetobacter baumannii strain ATCC BAA1605 using whole-genome sequencing
Authors: Ten Kah Ern , Md Zoqratt Muhammad Zarul Hanifah , Ayub Qasim , Tan Hock Siew 
Published: March 2021

Abstract
Objective
The nosocomial pathogen, Acinetobacter baumannii, has acquired clinical significance due to its ability to persist in hospital settings and survive antibiotic treatment, which eventually resulted in the rapid spread of this bacterium with antimicrobial resistance (AMR) phenotypes. This study used a multidrug-resistant A. baumannii (strain ATCC BAA1605) as a model to study the genomic features of this pathogen.

Results
One circular chromosome and one circular plasmid were discovered in the complete genome of A. baumannii ATCC BAA1605 using whole-genome sequencing. The chromosome is 4,039,171 bp long with a GC content of 39.24%. Many AMR genes, which confer resistance to major classes of antibiotics (beta-lactams, aminoglycosides, tetracycline, sulphonamides), were found on the chromosome. Two genomic islands were predicted on the chromosome, one of which (Genomic Island 1) contains a cluster of AMR genes and mobile elements, suggesting the possibility of horizontal gene transfer. A subtype I-F CRISPR-Cas system was also identified on the chromosome of A. baumannii ATCC BAA1605.
This study provides valuable genome data that can be used as a reference for future studies on A. baumannii. The genome of A. baumannii ATCC BAA1605 has been deposited at GenBank under accession no. CP058625 and CP058626.
Assessment of cerebral hemodynamics in multiple sclerosis patients
Authors: Salah Nouran M. , Elsadek Ahmed M. , ELnabil Lobna M. , Nassef Ayman M. , Abdelaziz Azza A. , Abdel Hafeez Mohamed A. 
Published: March 2021

Abstract
Background
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Autonomic dysfunction is present in a wide range of patients (15–80%) that might present with abnormalities in the regulation of the cardiovascular system, sleep disturbance, urinary symptoms, sexual problems, and temperature regulation problem. Although the predominant view is that of an autoimmune inflammatory condition, changes in brain vasculature can occur and contribute to pathophysiology.

Objectives
The aim of this study was to evaluate cerebral hemodynamics and assess autonomic dysfunction in patients with MS and explore its relationship with disease status.

Methods
Eighty patients diagnosed with MS according to McDonald criteria 2017 were recruited to this comparative cross-sectional study. All participants underwent assessment of cerebral hemodynamics through transcranial Doppler ultrasonography. Cerebral vasomotor reactivity (CVR) to hypercapnia was measured by the breath-holding index (BHI). They were also assessed for autonomic dysfunction by autonomic questionnaire and blood pressure measurements in both erect and supine positions.

Results
BHI values showed decreased CVR and were significantly lower in SPMS than in RRMS patients. Autonomic functions were more affected in SPMS than RRMS with total score 2.58 ± 1.13 for the RRMS group and 4.05 ± 1.04 for the SPMS group.

Conclusions
Cerebrovascular hemodynamic insufficiency in MS may be secondary to the downstream effects of neuro-inflammatory cascades.
Computed tomography angiography findings predictive of post-intervention vasospasm in patients with aneurysmal subarachnoid hemorrhage
Authors: Colip Charles G , Wo Sean , Hippe Daniel S , Watase Hiroko , Urdaneta-Moncada Alfonso R , Zhu Chengcheng , Wu Lei , Vranic Justin E , Kelly Cory M , Levitt Michael R , Mossa-Basha Mahmud 
Published: March 2021

Objective:
To evaluate the association of CT/CT angiography (CTA) findings and clinical characteristics with subsequent vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods-:
Consecutive presentation CTA head exams in patients with aSAH between January 2005 and June 2015 were retrospectively evaluated for intracranial arterial calcification, undulation and non-calcified stenosis. Additional variables including modified Fisher Scale (mFS), Glasgow Coma Scale (GCS) and neurological exam status were reviewed. Associations of CTA findings with the incidence of angiographic vasospasm were assessed with multivariate logistic regression models using the least absolute shrinkage and selection operator machine-learning algorithm. Model performance was summarized using c-index with bootstrap optimism-adjustment.

Results
Intracranial arterial calcification, seen in 51.7% of 195 total patients, was protective against vasospasm (OR-0.6; 95% CI-0.52–0.67; p = 0.009), while arterial undulation (24%) was associated with subsequent vasospasm (OR-2.6; 95% CI-1.3–5.1; p = 0.007). Non-calcified intracranial arterial stenosis (5%) was associated with subsequent vasospasm, (OR-4.7; 95% CI-1.0–22.8; p = 0.054). Least absolute shrinkage and selection operator selected all three CTA findings as predictors in a multivariate model for vasospasm in addition to clinical factors, which demonstrated superior predictive performance (c-index-0.74; 95% CI-0.69–0.82) compared to a model based on mFS and clinical factors only (c-index-0.66; 95% CI-0.57–0.75; p = 0.010 for the difference).

Conclusion:
Presentation CTA findings combined with clinical factors may better predict the development of vasospasm in patients with aSAH compared to current prognostic models alone.

Advances in knowledge:
The combination of initial CT/CTA and clinical findings better predict development of vasospasm after aSAH. This can lead to better markers for use in future clinical trials to develop vasospasm preventative treatments and potentially provide better targets for early aggressive treatment.
ПЕРСПЕКТИВЫ КИТАЙСКО-РОССИЙСКОГО СОТРУДНИЧЕСТВА В ОБЛАСТИ СТРАХОВАНИЯ
Authors: Wang Wentao 
Published: March 2021

Статья посвящена состоянием страхового рынка России и Китая. Рассмотрены вопросы деятельности крупнейших страховых компаний России и Китая. проанализированы основные перспективы китайско-российского сотрудничества в области страхования. В эпоху стремительного технологического развития 21 века уровень жизни людей значительно повысился, и цифровая экономика вступила в период всестороннего развития. Стремительное развитие цифровой экономики заложило основу для цифровизации страхового рынка Китая, поэтому страховой рынок имеет широкие перспективы развития. Страховой рынок – это фиксированная торговая площадка, такая как страховая биржа. Объектами сделок на страховом рынке являются различные страховые защиты и другие страховые услуги, предоставляемые страховщиками от рисков, с которыми сталкиваются потребители, то есть различные страховые продукты. Основная часть страхового рынка, объект страхового рынка и носитель страхового рынка образуют систему структуры страхового рынка. Эти три элемента взаимосвязаны и взаимно ограничивают друг друга для поддержания стабильной работы и здорового развития страховой отрасли.Цель – определение способов и приемов анализа, применяющих при проведении анализа китайско-российского сотрудничества в области страхованияМетод или методология проведения исследования. В статье использовались теоретические методы, практические методы, методы анализа кейса, статистические методы и сравнительные методы.Результаты. Получены наиболее информативные параметры, показывающие некоторые аспекты широких перспектив для сотрудничества и развития в сфере страхования между Китаем и Россией.Область применения результатов. Полученные результаты целесообразно применять экономическими субъектами, осуществляющими внешнеэкономическую деятельность, одним из элементов которой являются страховые рынки.
PENGARUH PENYULUHAN SAFETY RIDING DENGAN MEDIA AUDIO VISUAL TERHADAP PENINGKATAN PERILAKU BERKENDARA
Authors: Saputro Dryo , Handayani Lina , Dewi Maya Kusuma 
Published: March 2021

Indonesia is a country with a high level of traffic accidents. Traffic accidents in Indonesia according to the World Health Organization is the third largest killer under coronary heart disease and tuberculosis. Traffic accidents are caused by several factors including human factors, vehicle factors, road factors, environmental factors and weather factors. Teenagers are one of the biggest contributors to traffic accidents. Age 13-18 years is the early teens where they just felt an interest in trying to ride a motorcycle. Teenagers think that they are mature enough to drive vehicles on the road, with the knowledge of shallow driving causing accidents. Traffic safety is greatly influenced by driver’s discipline. Driver’s discipline can increase the level of traffic safety. The purpose of this study is to determine the effect of providing audiovisual safety riding counselling to the knowledge and attitude of driving. The research was a quasi-experimental with one-group pre-test post-test design. Respondent in this study was 70 Muhammadiyah 4 Yogyakarta high school students. The sample was gathered by purposive sampling technique. The instrument used was a questionnaire. The study began with a pre-test and then a video screening and conducted a post-test with the same questionnaire. The data analysis test was the parametric paired sample T-test, the non-parametric Wilcoxon test. The results of the non-parametric Wilcoxon test analysis obtained p-value of 0.000. The results showed that there was an influence of counselling with audiovisual safety riding methods on knowledge. The results of the paired sample T-test test analysis obtained 0.000 which shows the effect of providing audiovisual safety riding on attitudes. There is an effect of counselling using audiovisual safety riding methods on students' knowledge and driving attitudes.
HUBUNGAN STATUS GIZI DENGAN KEJADIAN ANEMIA PADA IBU HAMIL DI PUSKESMAS KOTAGEDE II YOGYAKARTA
Authors: Sari Larasajeng Permata , Sarwinanti Sarwinanti , Djannah Sittti Nur 
Published: March 2021

Maternal deaths in Yogyakarta Special Region are caused by heart disease, bleeding, eclampsia, sepsis/infection. Bleeding is still the number one causes of maternal death. Pregnancy with anaemia is 5 times more at risk of bleeding than who are not. The aims of the research are to determine the relationship of nutritional status with anaemia in pregnant women in Kotagede II Yogyakarta Public Health Center. This was an observational analytic design and a cross-sectional approach. The sampling method uses accidental sampling technique. The number of respondents was 77 pregnant women in the second and third trimester. The research instrument used questionnaire sheets and medical records. Data were processed by Chi-Square statistical tests. Study found (p-value) of nutritional status = 0.001. The conclusion of this study is that there was a significant relationship between nutritional status with the incidence of anaemia at Kotagede II Yogyakarta Health Center
Experiences of violence and mental health outcomes among Asian American transgender adults in the United States
Authors: Becerra Monideepa B. , Rodriquez Erik J. , Avina Robert M. , Becerra Benjamin J. 
Published: March 2021

Purpose
We addressed prevalence and factors associated with mental health outcomes (suicidal behavior and psychological distress) among Asian Americans (AA), who identify as transgender, a key group among sexual and gender minorities that is overlooked and understudied.

Methods
We used data from 2015 United States Transgender Survey during 2019–2020 with our population as census defined AA. Outcomes included suicidal ideation, suicidal thoughts, and serious psychological distress (SPD). Independent variables included any abuse, partner abuse, bathroom-related abuse, and additional covariates. Adjusted odds ratio and 95% confidence interval (aOR; 95% CI) for each outcome are adjusted for age, marital status, citizenship status, education level, employment status, as well as poverty status.

Results
Nearly 67% reported experiencing any abuse, 52% reported abuse from romantic/sexual partner(s), while 29% reported harassment/abuse when trying to use bathrooms. Moreover, 82% reported suicidal thoughts, 40% reported suicidal attempts, and 39% had SPD. Results demonstrated that any abuse/violence had higher odds of suicidal thoughts (adjusted odds ratio [aOR] = 2.67, 95% confidence interval (CI):[1.98–3.58], suicidal attempts (aOR = 2.83, 95% CI:[2.18–3.68]), and SPD (aOR = 1.56, 95% CI:[1.20, 2.04]). Abuse from romantic/sexual partners had higher odds of suicidal thoughts (aOR = 2.47, 95% CI:[1.76–3.47]), suicidal attempts (aOR = 2.17, 95% CI:[1.68–2.80]), and SPD (aOR = 2.72, 95% CI:[2.03–3.63]). Experience of harassment/abuse during bathroom use had increased odds of suicidal attempts (aOR = 1.81, 95% CI:[1.41–2.31]).

Conclusion
Exposure to violence is common among AA transgender individuals and related to negative mental health outcomes. Initiatives to reduce exposure to abuse and providing resources for trauma-informed care are imperative to improve health outcomes.