bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the pharmacokinetics and safety of blonanserin tablets and Lonasen®: a randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial
Authors: Qiu Bo , Song Haojing , Sun Xue , Ding Congyang , Du Runxuan , Bai Wanjun , Dong Zhanjun 
Published: January 2025

ObjectiveThis study evaluated the pharmacokinetic and safety profiles of generic and original blonanserin tablets under fasting and postprandial conditions, and the bioequivalence of two formulations to obtain sufficient evidence for abbreviated new drug application.MethodsA randomized, open-label, two-period, two-sequence, self-crossover bioequivalence study was conducted to assess the bioequivalence of the test and reference blonanserin tablets under fasting and postprandial conditions. Eligible healthy individuals received a single 4-mg dose of either the test or reference blonanserin tablet, followed by a wash out period of 14 days. Serial blood samples were collected for up to 72 h after administration during each period, and the plasma concentrations of blonanserin were determined using a validated method. The non-compartmental method was used to calculate the primary pharmacokinetic parameters, and the geometric mean ratios for the PK parameters of the test drug to those of the reference drug, along with the corresponding 90% confidence intervals, were obtained for bioequivalence analysis. Throughout the study, a safety evaluation was conducted.ResultsUnder both fasting and postprandial conditions, the pharmacokinetic parameters of the test drug were found to be similar to those of the reference drug. The 90% confidence intervals (CIs) of the geometric mean ratios of the test to reference formulations were 97.79%–118.28% for peak concentration (Cmax), 92.35%–111.78% for the area under the curve from zero to the last measurable concentration (AUC0-t) and 92.88%–111.91% for the AUC from zero to observed infinity (AUC0-∞) under fasting conditions, 88.65%–103.20% for Cmax, 95.89%–106.81% for AUC0-t and 96.02%–106.91% for AUC0-∞ under postprandial conditions, all of which were within the accepted bioequivalence range of 80.00%–125.00%. Both the test and reference formulations were well-tolerated, and no serious adverse events related to the study drug were reported during the study.ConclusionThe bioequivalence of blonanserin tablets, both test and reference, was confirmed in healthy Chinese subjects under fasting and postprandial conditions, meeting the predetermined regulatory criteria for both formulations. Both formulations were found to be safe and well tolerated.Clinical Trial Registrationhttp://www.chinadrugtrials.org.cn/index.html, identifier CTR20230703.
Autonomous learning and creative cognition: the mediating effect of gifted students’ self-efficacy
Authors: Orakcı Şenol 
Published: January 2025

IntroductionIn today’s world, it is of great importance to raise qualified learners whose creative thinking skills and self-efficacy are developed and who can make various choices and take responsibility for their choices as well as implementing them by making their own decisions. In this regard, the study examined the role of gifted students’ self-efficacy (SE) as a mediator on the relationship between autonomous learning (AL) and creative cognition (CC).MethodsA proposed conceptual model was tested using a cross-sectional survey design. Based on “convenience sampling,” the study group consisted of 528 gifted secondary school students enrolled in three Science and Arts Centers in Ankara, Türkiye in the 2022–2023 academic year. A two-step Structural equation modelling (SEM) analysis was conducted for data analysis.Results and discussionThe findings revealed that AL positively and significantly predicted CC, SE was positively correlated with CC, and both dimensions of AL (Independence of Learning- IoL and Study habits- SH) had a significant direct and indirect influence on CC via SE, confirming that the dimensions of AL (IoL and SH) had distinct indirect influences on CC via SE. The study improves our understanding of the role that SE beliefs play in the interaction between AL and CC, which helps to expand and improve models that represent these processes. In order to create conditions that encourage AL, foster SE beliefs, and eventually improve CC among gifted students, educators, policymakers, and parents can create a learning environment that not only promotes AL and strong SH but also fosters SE and CC, ultimately leading to more innovative and self-reliant students.
The impact of industrial synergistic agglomeration on residents’ health levels
Authors: Qi Di , Xu Wenhan 
Published: January 2025

IntroductionThis study investigates the impact of industrial synergistic agglomeration on residents’ health levels in China. It explores how green and traditional industry agglomeration models influence residents’ health levels outcomes and identifies the underlying mechanisms driving these effects.MethodsUsing panel data from 283 prefecture-level cities and above in China from 2003 to 2020, the study applies the Generalized Spatial Two-Stage Least Squares (GS2SLS) method. This approach allows for a systematic analysis of both direct and spatial spillover effects, focusing on the comparative impacts of green and traditional industrial agglomeration models.Results(i) Spatial Effects: Residents’ health levels exhibits a significant positive spatial effect, with public health improvements in one city positively influencing neighboring cities.(ii) Industrial Agglomeration: Industrial synergistic agglomeration has a stronger positive impact on residents’ health levels compared to single-industry agglomeration.(iii) Mechanisms: The effect of industrial synergistic agglomeration on residents’ health levels operates through three primary mechanisms:- Population Agglomeration Effects: Enhanced population clustering contributes to better public health services.- Media Dissemination Effects: Improved information dissemination raises public health awareness.- Income Growth Effects: Increased income levels drive better access to healthcare and lifestyle improvements.(iv) Model Comparison: Green industry synergistic agglomeration proves more beneficial for residents’ health levels improvement than traditional industry agglomeration.DiscussionThe findings highlight the critical role of industrial synergistic agglomeration, particularly in green industries, in promoting residents’ health levels. Policymakers are encouraged to prioritize strategies fostering green industry clustering and to leverage the identified mechanisms to amplify public health benefits across regions.
Buffering or not working: group counseling for depression and loneliness among boarding primary school students
Authors: Wang Peng , Ma Junchi , Du Longlong , Xing Qiulian , Cheng Xinyu , Zhang Mingzhu , Geng Fei , Zheng Yuanxin , Zheng Fangxiao , Tian Mei 
Published: January 2025

IntroductionDue to the acceleration of modern life rhythm, students with developing minds are susceptible to negative external influences, leading to a growing concern for their mental health. Boarding primary school students have limited interaction with relatives compared to their non-boarding counterparts, rendering them more prone to feelings of depression and loneliness, resulting in various negative emotions. Therefore, our study aimed to explore the effects of group counseling interventions on reducing depression and loneliness among adolescents.MethodsThe study analyzed loneliness and depression before and after the intervention in eight randomly selected classes of fifth-grade students at a boarding school in a region of Shandong Province, which were divided into an experimental group and a control group.ResultsWithin the experimental group, there were no substantial variations in loneliness and depression levels. In the control group, post-test depression results significantly surpassed pre-test scores (p = 0.046), though loneliness levels did not differ significantly. Conversely, the experimental group displayed significantly reduced post-test depression levels compared to the control group (p = 0.037), with no significant variance in loneliness.ConclusionThe findings indicated that group psychological counseling mitigates depression in the experimental group to a certain extent, affirming the efficacy of the intervention. The study demonstrated that group counseling alleviates depression in boarding students, emphasizing the value of the intervention.
Examining the prevention approach in National Dementia Plans from European and North American countries
Authors: Andreoletti Mattia , Blasimme Alessandro 
Published: January 2025

ObjectivesThis paper aims to provide a comprehensive review of National Dementia Plans (NDPs) from selected European and North American countries, focusing on the distinct prevention strategies outlined and the approaches employed for reducing dementia risk.MethodThe sample consisted of 16 NDPs from Austria, Canada, Finland, France, Germany, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Malta, the Netherlands, Spain, Switzerland, the UK, and the USA. These NDPs were retrieved from the Alzheimer's Disease International (ADI) database, with regular updates checked on official governmental websites. A qualitative analysis was conducted to identify common themes related to the vision, goals, and corresponding actions and measures within these strategies.ResultsOur analysis revealed that dementia prevention is a strategic goal for most of the countries studied. Common actions identified include the identification of risk factors, advancing research, promoting healthy aging, increasing public awareness, and encouraging lifestyle interventions.ConclusionWe discuss the limitations and challenges of these actions, and more broadly, of the NDPs in relation to the recent literature on the most effective approaches to preventing dementia. We suggest adopting a more “horizontal” approach to dementia prevention, which current NDPs overlook in favor of “vertical” paradigms.
Socio-Economic Factors Influencing Intimate Partner Violence Among Adolescents and Young Women in Sub-Saharan Africa: A Scoping Review
Authors: Ikuteyijo Olutoyin Opeyemi , Zepro Nejimu , Akinyemi Akanni Ibukun , Probst-Hensch Nicole , Merten Sonja 
Published: January 2025

ObjectiveTo summarize the evidence on how socio-economic status and intimate partner violence (IPV) are interrelated among adolescents and young women (AYW) in sub-Saharan Africa (SSA).MethodsOnline databases such as MEDLINE, Embase, PsycIFO, CINAHL, Cochrane Central, Sociological Abstracts, Web of Science, and the African Index Medicus were used to identify studies published between 2015 and 2022. The reporting procedure was the Preferred Reporting Item for Systematic Reviews and Meta-Analysis (PRISMA) as a checklist extension for the scoping review.ResultsThe majority of the publications, ten (62.5%) were cross-sectional studies, while four (25%) were qualitative studies and two (12.5%) were mixed methods studies. The review found that lack of financial resources exposed AYW to all forms of violence ranging from physical, sexual, emotional, psychological, and economic violence. Nonetheless, financial reliance on a partner poses a long-term threat to AYW employment and financial stability.ConclusionSocio-economic status influences the level of IPV experienced by AYW in many countries of SSA, while evidence of the long-term effects remains uncovered. To achieve Sustainable Development Goal (SDG) 1, which focuses on ending poverty in all forms by 2030, socio-economic inequalities caused by IPV among AYW require prompt interventions.
The Health and Health Insurance Implications of Climate Change in Sub-Saharan Africa: A Narrative Review
Authors: Traoré Ousmane , Tetka Jean Brice 
Published: January 2025

ObjectivesThis paper aims to provide a narrative review of the implications of climate change on health and health insurance in sub-Saharan Africa.MethodsA comprehensive research was employed to carry out a complete narrative study on the subject. Thus, since September 2022 we searched for literature on the relationships between climate change, health, and health insurance on PubMed over an unbounded period. By updating the research method, the outputs cover the period 2009–2024.ResultsBased on 19 key articles that focused on the implications of climate change for health and health insurance in sub-Saharan Africa, we highlight that climate change directly affects population health through climate-related disease. Indirectly, climate change affects health through its disruption of food availability and agriculture and through demographic shifts.ConclusionFinally, this narrative review suggests appropriate strategies to combat the health consequences of climate change and to improve universal health insurance systems.
Integrating Maternal and Child Health Into Climate Change: A Holistic Approach
Authors: Amekpor Felix , Sakariyau Waheed , Kengo Nathan Ezie , Sandra Nwodo Amarachukwu , Agyapong Joseph , Dauda Zakariya’u , Kwarteng Samuel , Adedokun David Adeoye , Darko Gideon 
Published: January 2025

ObjectivesIn everyday language, climate change is an increase in the Earth’s average temperature. Climate change negatively affects life support systems, including air, food, water, shelter, and security, on which humans depend. This paper aims to holistically integrate maternal and child health into climate change.MethodsA narrative/literature review approach were adopted using papers sources from google scholar, research gate and web of science. About 10 papers was initially gathered and it was later scrutinized to 6.ResultsIt was discovered that, climate change negatively impacts food and water security, heat stress, extreme weather, and air pollution, with women and children most affected. The World Health Organization estimates 250,000 climate-related deaths annually by 2050, disproportionately affecting maternal and child health. Integrating climate and maternal health strategies could offer benefits, yet research on adapting to climate change’s effects on pregnancy outcomes is limited.ConclusionAddressing maternal and child health requires integrating health-focused strategies into environmental policies to reduce vulnerabilities to climate-related risks. A comprehensive approach can enhance resilience by improving healthcare access, education, and sustainable resource management, benefiting public health and environmental outcomes.
Examination of non-conventional dysplasias adjacent to colorectal adenocarcinoma in patients with IBD
Authors: Almási Szintia , Balajthy Zsófia , Baráth Bence , Török Zsófia Krisztina , Szaszák Panna , Lantos Tamás , Kővári Bence , Sejben Anita 
Published: January 2025

ObjectiveRecently, several non-conventional variants of IBD-associated dysplasia have been described; however, their prevalence in Central-Eastern Europe is unknown. We aimed to perform a retrospective pilot study by re-evaluating several IBD-associated adenocarcinoma cases to survey the incidence of adjacent non-conventional dysplasia and validate that recent North American findings may apply to a European population.MethodsRetrospectively, 28 randomly chosen cases of IBD-associated adenocarcinomas diagnosed between 2010 and 2022 were re-evaluated. The patient’s sex, age (at the diagnosis of IBD and neoplasia), type of IBD, type of specimen [biopsy (n = 8)/surgical specimen (n = 20)], histological type, grade, localisation, stage, disease-free (DFS) and overall survival (OS) were obtained. Statistical analyses were carried out by using Mann-Whitney (continuous variables), Fisher’s exact (categorical variables), Kaplan-Meier (DFS/OS curves), and logrank test (survival curves).ResultsExclusively, conventional dysplasia was observed in 11, and non-conventional dysplasia in 8 patients. Combined conventional and non-conventional dysplasia was detected in 9 patients. Non-conventional dysplasia showing a combination of multiple subtypes was noted in 10 cases. Altogether, 25 non-conventional dysplastic foci were identified, which were diagnosed as hypermucinous (n = 9), goblet cell-deficient (n = 6), serrated not otherwise specified (NOS) (n = 6), and traditional serrated adenoma-like (n = 4). The majority of non-conventional dysplasias were associated with ulcerative colitis (n = 12). Mucinous adenocarcinoma was exclusively associated with non-conventional dysplasia, while medullary carcinoma was only with conventional dysplasias (p = 0.014 and 0.041).ConclusionBased on our results, non-conventional dysplasia is common (60%) adjacent to IBD-associated adenocarcinomas in a Central-Eastern European population and may be detected in biopsies. As multiple recent publications reported evidence of a worse prognosis and more common flat morphology compared to conventional dysplasias, their recognition is of great importance, and stricter follow-up with random biopsy samples may be considered.
«La Europa no puede civilizarse»: colonialismo y desespañolización en Francisco Bilbao
Authors: Sanhueza Marcelo 
Published: January 2025

The article examines Francisco Bilbao’s essay "El Evangelio Americano" (1864) with respect to Bilbao’s criticism of European colonialist actions, as well as his displacement of the Old World as a unique paradigm of civilization and modernity. Within this framework, the author contends that Bilbao both portrays and rejects colonialism in the binary historical-cultural sense, since Bilbao alludes to the Hispanic past and to the South American present in the throes of European colonial interventions. Faced with this, Bilbao argues that in America an emancipation is developing that is not only political, but also cultural and intellectual, which is capable of freeing from oppression the disinherited, such as Native Americans, whom in his essay Bilbao transforms into agents of rebellion against history.
Distance Learning as a Means of Innovative Teaching for University Students During the COVID-19 Pandemic
Authors: Sufa Beata , Bocharova Olena , Popławska Agata 
Published: January 2025

Research objectives and problems: The aim of the study was to investigate students’ opinions on distance education. The following research questions were posed: 1: How effective was the communication between lecturers and students? 2: What problems did students encounter during remote education? 3: What were the advantages of remote education in the opinion of students? 4: How did students assess the overall quality of remote education?
Research methods: The study employed a questionnaire developed by the researchers to gather the views of students about distance education. The questionnaire was informed by a literature review examining student attitudes toward remote learning. Based on the research questions, the questionnaire items were revised and compiled into a comprehensive item pool.
A brief description of the context of the presented issue: Distance education requires a reorganization of the teaching and learning process, particularly concerning the roles of both teachers and students. The purpose of this article is to contribute to pedagogical knowledge by discussing innovative approaches adopted at the Pedagogy Department of the National Education Commission University in Krakow during the COVID-19 pandemic.
Research findings and their influence on the development of pedagogical science: The widespread adoption of distance learning was initially fueled by the urgent need for adaptation measures during the pandemic. However, the demand for new teaching models is also a response to rapid societal shifts, increasing digitalization, and evolving student expectations. The integration of modern educational methods at the university level is becoming not only a necessity, but also a challenge that requires updating curricula to meet current needs and technological advancements.
Conclusions and/or recommendations: The findings indicate that students are receptive to modern forms of education, in which digital competences play an important role. This study, conducted during the COVID-19 pandemic, is not exhaustive; it merely serves as a starting point for further reflection and analysis. It would be interesting to carry out a similar follow-up study to compare student opinions from different time periods.
Pengaruh Gaya Hidup, Kualitas Produk, dan Promosi terhadap Keputusan Pembelian Produk Makanan Sehat Soyjoy
Authors: Sukmawati Novita , Ekasasi Sri Rejeki 
Published: January 2025

Gaya hidup sehat sudah menjadi kebutuhan yang tidak bisa lepas dari kehidupan sehari-hari sehingga menyebabkan permintaan akan produk sehat semakin meningkat, termasuk pada makanan ringan sehat Soyjoy. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh gaya hidup, kualitas produk, dan promosi terhadap keputusan pembelian produk Soyjoy di Yogyakarta. Populasi dalam penelitian ini adalah konsumen produk Soyjoy di Yogyakarta. Metode sampel non probability sampling dengan jumlah 100 responden menggunakan metode Roscoe dan teknik pengambilan purposive sampling melalui Google form. Uji yang digunakan adalah uji validitas, uji reliabilitas, uji normalitas, uji heterokedastisitas, uji multikolinearitas, uji regresi linier berganda, uji F, uji t, dan uji koefisien determinasi. Penelitian ini menyimpulkan bahwa gaya hidup, kualitas produk, dan promosi secara parsial berpengaruh positif dan signifikan terhadap keputusan pembelian.
Pengaruh.Harga, Promosi, dan Citra Merek terhadap Keputusan Pembelian Produk Blush On Emina di Yogyakarta
Authors: Dema Fifi Uswatun Hasanah , Rokhman Nur 
Published: January 2025

Competition.between the personal. care and cosmetics industry. markets is increasingly competitive. This is. evidenced by the many types of cosmetics in circulation both domestic and. foreign production.. The flood of cosmetic products on the market influences one’s attitude towards purchasing decisions and the use of goods. Purchase a product is no longer to meet the needs (needs), but because of the desire (want). Coupled with the discovery of consumers deciding to choose to use certain products (cosmetics) in order to clarify their identity so that it is seen well in certain communities. The research method uses quantitative methods .with sampling.techniques using. nonprobability. purposive sampling., sample size is 100. Using multiple .linear regression. .analysis and the. coefficient of .determination at. a significant level of.5%. Data collection techniques using questionnaire techniques. The .results showed that. price, .promotion., and. brand image variabels had.a significant positive effect on purchasing decisions. The magnitude .of the effect of. price, promotion, and brand image on purchasing decisions 79.9% and the.remaining 20.1%..is influenced. by other. variabels not.included in.This. study.