bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trichrome-positive intrahepatic cytoplasmic globules are potential histopathological clue for COVID-19-induced hepatitis: a case report
Authors: Sweed Dina , El Shanshory Mohamed Ramadan , Elaskary Eman Mohammed , Hassan Hassnaa Atef , Sweed Enas , Sweed Eman , Abdelsattar Shimaa , Abdelgawad Ahmed , Mosbeh Asmaa , Abdallah Heba , El-Mashad Shereen , Ehsan Nermine 
Published: August 2021

Abstract
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly affects respiratory system. Later, liver affection has also been reported in the form of marked elevated liver enzymes. However, the association of coronavirus disease-19 (COVID-19) and autoimmune diseases is not clear.

Case presentation
A female patient with a known history of autoimmune hemolytic anemia (AIHH) for which she was treated with prednisolone was admitted for uncontrolled anemia followed by fever and elevated liver enzymes. All the laboratory and radiological investigations were not typical for COVID-19 or any other etiology. Liver biopsy revealed numerous pale eosinophilic trichrome-positive intracytoplasmic globules. The pathology raised the suspicion for SARS-CoV-2-associated hepatitis, which was confirmed by a positive IgG titer. The patient showed a dramatic improvement on the maintenance dose of prednisolone.

Conclusions
AIHA patients co-infected with SARS-CoV-2 may be at risk of uncontrolled disease and should continue their treatment regimen. Histopathology has a role in the diagnosis of liver affection due to SARS-CoV-2 infection.
Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant
Authors: Afrin Syeda Rubaiya , Islam Mohammad Rashedul , Khanam Bibi Humayra , Proma Nawreen Monir , Didari Sayeda Saima , Jannat Sarah Waddun , Hossain Mohammed Kamrul 
Published: August 2021

Abstract
Background
Macropanax dispermus is traditionally used to treat various diseases by ethnic people. The present research reports the pharmacological properties with phytochemical profiling of the crude extracts of M. dispermus leaves (MDML), its n-hexane (MDHL), carbon tetrachloride (MDTL), chloroform (MDCL), ethyl acetate (MDEL), and aqueous (MDAL) fractions, and crude methanol extracts of its stem barks (MDMS). The in vitro thrombolytic activity was done on human erythrocytes whereas the cytotoxic activity was done by brine shrimp lethality assay. The in vivo analgesic activity was examined by acetic acid-induced writhing, tail immersion, and formalin-induced paw licking method. In contrast, antipyretic activity was done by the brewer’s yeast-induced pyrexia method.

Results
MDHL and MDMS showed 37.05% and 42.21% of significant (p < 0.01) thrombolytic activity, respectively. MDCL and MDMS showed the lower LC50 values of 23.15 and 37.11 µg/ml during cytotoxicity test, respectively. In acetic acid writhing method, MDTL and MDEL showed significant (p < 0.001) inhibition of writhing by 79.34% and 80.17%, respectively. MDMS showed significant (p < 0.001) maximal possible effect (%MPE) of 45.95%, 62.26%, 65.79%, 89.69% and elongation of time in pain reaction of 48.53%, 60.28%, 58.76%, and 70.14% at 30, 60, 90, and 120 min intervals, respectively. MDML at 400 mg/kg exhibited significant (p < 0.001) 82.72% of inhibition of pain at the late phases. MDEL at 400 mg/kg of dose exhibited significant (p < 0.001) reduction of rectal temperature by 36.31%, 62.42%, 89.81%,, and 96.82% at 1, 2, 3, and 4 h intervals, respectively.

Conclusion
The current research suggests that the plant extracts possess potential thrombolytic, cytotoxic, analgesic, and antipyretic activities.
Curcuma zedoaria Rosc (Zingiberaceae): a review on its chemical, pharmacological and biological activities
Authors: Gharge Shankar , Hiremath Sushmita I. , Kagawad Pooja , Jivaje Kadambari , Palled Mahesh S. , Suryawanshi Shailendra S. 
Published: August 2021

Abstract
Background
Around 80% of human population in the world relies on herbal or phytomedicines for their primary health care needs. The treatment of many diseases and disorders with phytomedicines is considered and observed as very safe with no or minimal side effects. Many medicinal plants and their preparations are practised at home as remedies for treating and preventing various diseases and disorders. For example, medicinal plants and their crude parts such as tulsi, neem, turmeric and ginger are used to cure or treat several common ailments, out of which Curcuma zedoaria Rosc commonly known as white turmeric is one of the important crude drugs belonging to Zingiberaceae family and genus Curcuma. Traditionally, it has been reported to possess many biological activities been used for many therapeutic actions due to the presence of wide range of phytoconstituents in it. The main objectives of the present work are to carry out extensive review on its chemical, pharmacological and biological activities of plant.

Main body
In the present review article, extensive data on its chemical, pharmacological and biological activities have been collected from various online sources including indexing sites such as Web of Science, Scopus, PubMed and Research Gate and presented. Various articles published in indexed journals and other databases have been collected and reviewed systematically.

Conclusion
The present review investigation is very much helpful for researchers and readers to collectively have valuable information on chemistry, pharmacology and biological effects of Curcuma zedoaria Rosc. The present investigation concludes that the white turmeric is found to possess complex range of phytoconstituents such as curcumin, ethyl p-methoxycinnamate, β-turmerone, β-eudesmol, zingiberene, dihydrocurcumin, furanodiene, α-phellandrene, 1–8 cineole, β-elemense and germacrone. Due to the presence of wide range of phytoconstituents, plants have been reported for its diverse biological activities.
The alternative oxidase (AOX) increases sulphide tolerance in the highly invasive marine invertebrateCiona intestinalis
Authors: Bremer Katharina , Yasuo Hitoyoshi , Debes Paul Vincent , Jacobs Howard Trevor 
Published: August 2021

ABSTRACTEcological communities and biodiversity are shaped by both abiotic and biotic factors. This is well illustrated by extreme environments and invasive species. Besides naturally occurring sulphide-rich environments, global change can lead to an increase in hydrogen sulphide episodes that threaten many multicellular organisms. With the increase in the formation, size and abundance of oxygen minimum zones and hypoxic environments, bacterial-associated sulphide production is favoured and, as such, hydrogen-sulphide-rich environments are likely to also increase in size and abundance. Many species are challenged by the inhibiting effect of sulphide on aerobic energy production via cytochrome c oxidase, ultimately causing the death of the organism. Interestingly, many protist, yeast, plant and also animal species possess a sulphide-resistant alternative oxidase (AOX). In this study, we investigated whether AOX is functionally involved in the sulphide stress response of the highly invasive marine tunicate Ciona intestinalis. At the LC50, the sulphide-induced reduction of developmental success was three times stronger in AOX knock-down embryos than in control embryos. Further, AOX mRNA levels were higher under sulphide than under control conditions, and this effect increased during embryonic development. Together, we found that AOX is indeed functionally involved in the sulphide tolerance of C. intestinalis embryos, hence, very likely contributing to its invasive potential; and that the response of AOX to sulphide seems to be controlled at the transcriptional level. We suggest that AOX-possessing species play an important role in shaping marine ecological communities, and this importance may increase under ongoing global change.
Synthesis of bismuth oxyhalide (BiOBrzI(1-z)) solid solutions for photodegradation of methylene dye
Authors: Gembo Robert O. , Aoyi Ochieng , Majoni Stephen , Etale Anita , Odisitse Sebusi , King'ondu Cecil K. 
Published: August 2021

Background: The removal of textile wastes is a priority due to their mutagenic and carcinogenic properties. In this study, bismuth oxyhalide was used in the removal of methylene blue (MB) which is a textile waste. The main objective of this study was to develop and investigate the applicability of a bismuth oxyhalide (BiOBrzI(1-z)) solid solutions in the photodegradation of MB under solar and ultraviolet (UV) light irradiation. Methods: Bismuth oxyhalide (BiOBrzI(1-z)) (0 ≤ z ≤ 1) materials were successfully prepared through the hydrothermal method. Brunauer-Emmett-Teller (BET), transmission electron microscope (TEM), X-ray diffractometer (XRD), and scanning electron microscope (SEM) were used to determine the surface area, microstructure, crystal structure, and morphology of the resultant products. The photocatalytic performance of BiOBrzI(1-z) materials was examined through methylene blue (MB) degradation under UV light and solar irradiation. Results: The XRD showed that BiOBrzI(1-z) materials crystallized into a tetragonal crystal structure with (102) peak slightly shifting to lower diffraction angle with an increase in the amount of iodide (I-). BiOBr0.6I0.4 materials showed a point of zero charge of 5.29 and presented the highest photocatalytic activity in the removal of MB with 99% and 88% efficiency under solar and UV irradiation, respectively. The kinetics studies of MB removal by BiOBrzI(1-z) materials showed that the degradation process followed nonlinear pseudo-first-order model indicating that the removal of MB depends on the population of the adsorption sites. Trapping experiments confirmed that photogenerated holes (h+) and superoxide radicals (•O2−) are the key species responsible for the degradation of MB. Conclusions: This study shows that bismuth oxyhalide materials are very active in the degradation of methylene blue dye using sunlight and thus they have great potential in safeguarding public health and the environment from the dye’s degradation standpoint. Moreover, the experimental results agree with nonlinear fitting.
Case Report: Occupational therapy in a patient with an overgrowth syndrome that restricts movement
Authors: Coppeta Luca , Gentili Sandro , Papa Francesca , De Zordo Ludovico Maria , Mugnaini Stefano , Pietroiusti Antonio 
Published: August 2021

Background: Overgrowth syndromes are a heterogeneous group of conditions characterized by excessive body growth - localized or generalized - commonly associated with various malformities and an increased oncological risk. Case report: Here we present the case of a 59-years old man, employed in an office, who suffers from an asymmetric overgrowth of the lower limbs. Currently the patient presents malformations of the lower left limb (hip, knee and ankle), evident on the articular and periarticular level, where there are diffuse exostoses. This case discusses the main occupational concerns relating to the patient’s workspace at a high floor level that could create critical issues in the event of an emergency exodus. Given the impossibility of placing the patient in heavy manual activities, employment is limited to office activities. Adjustments were carried out at the patient’s workstation, and thus the patient has been recognized as fit to work. Increased frequency of breaks were prescribed in order to allow the physiological alternation of postures. Conclusions: In cases of overgrowth syndromes, the exact identification of the limitations presented by the patient and observations about ambulatory functions must be carefully evaluated in order to modulate the work environment.
Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome
Authors: Zaki Maysaa El Sayed , Elhammady Dina , Foda Salama Mona , Abdelsalam Mostafa , Osman Asmaa Osama Bakr 
Published: August 2021

Background:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder, categorized into various subtypes. Post-infection IBS may be attributed to the release of cytolethal distending toxin B (CdtB), which cross-reacts with the adhesion protein vinculin responsible for normal intestinal contractility.Objective:This study aims to identify anti-CdtB and anti-vinculin levels in IBS patients compared to healthy control.Subjects and methods:This retrospective case-control study was conducted on 100 subjects with IBS, as determined by a questionnaire based on Rome III criteria, recruited from the outpatient clinics of the Tropical Medicine at Mansoura University Hospital from January 2019 to January 2020.Results:Anti-vinculin and anti-CdtB levels were significantly elevated in patients with IBS (1.58±0.496, 2.47±0.60) when compared to control subjects (1.13±0.249ng/ml, 2.1±0.24 ng/ml), respectively with P=0.001 for both. Anti-vinculin level was significantly higher in the IBS-D subtype than the other subtypes (P=0.001) while, Anti-CdtB was significantly elevated in IBS-C, IBS-D subgroups compared to control subjects (P=0.001).Conclusion:Findings of the present study support the hypothesis that IBS results from post-infectious disorders initiated by bacterial enteritis. A hypothesis could be applied to all IBS subgroups. On the other hand. These biomarkers might reflect the post-infectious state's severity.
Cost-effectiveness of surgical treatments compared with early structured physiotherapy in secondary care for adults with primary frozen shoulder
Authors: Corbacho Belen , Brealey Stephen , Keding Ada , Richardson Gerry , Torgerson David , Hewitt Catherine , McDaid Catriona , Rangan Amar ,   On behalf of the UK FROST trial team
Published: August 2021

Aims A pragmatic multicentre randomized controlled trial, UK FROzen Shoulder Trial (UK FROST), was conducted in the UK NHS comparing the cost-effectiveness of commonly used treatments for adults with primary frozen shoulder in secondary care. Methods A cost utility analysis from the NHS perspective was performed. Differences between manipulation under anaesthesia (MUA), arthroscopic capsular release (ACR), and early structured physiotherapy plus steroid injection (ESP) in costs (2018 GBP price base) and quality adjusted life years (QALYs) at one year were used to estimate the cost-effectiveness of the treatments using regression methods. Results ACR was £1,734 more costly than ESP ((95% confidence intervals (CIs) £1,529 to £1,938)) and £1,457 more costly than MUA (95% CI £1,283 to £1,632). MUA was £276 (95% CI £66 to £487) more expensive than ESP. Overall, ACR had worse QALYs compared with MUA (-0.0293; 95% CI -0.0616 to 0.0030) and MUA had better QALYs compared with ESP (0.0396; 95% CI -0.0008 to 0.0800). At a £20,000 per QALY willingness-to-pay threshold, MUA had the highest probability of being cost-effective (0.8632) then ESP (0.1366) and ACR (0.0002). The results were robust to sensitivity analyses. Conclusion While ESP was less costly, MUA was the most cost-effective option. ACR was not cost-effective. Cite this article: Bone Jt Open 2021;2(8):685–695.
Microwave Nondestructive Sensing of Moisture Content and Water Activity of Almonds
Authors: Trabelsi Samir 
Published: August 2021

HighlightsMoisture and water activity were determined nondestructively and in real time from measurement of dielectric properties.Moisture and water activity calibration equations were established in terms of the dielectric properties.Situations in which bulk density was known or unknown were considered.SEC ranged from 0.41% to 0.68% for moisture and from 0.02 to 0.04 for water activity.Abstract. A method for rapid and nondestructive determination of moisture content and water activity of granular and particulate materials was developed. The method relies on measurement of the dielectric constant and dielectric loss factor at a single microwave frequency. For the purpose of illustration, the method was applied to predicting the moisture content and water activity of almond kernels. A free-space transmission technique was used for accurate measurement of the dielectric properties. Samples of Bute Padre almond kernels with moisture content ranging from 4.8% to 16.5%, wet basis (w.b.), and water activity ranging from 0.50 to 0.93 were loaded into a Styrofoam sample holder and placed between two horn-lens antennas connected to a vector network analyzer. The dielectric properties were calculated from measurement of the attenuation and phase shift at 8 GHz and 25°C. The dielectric properties increased linearly with moisture content, while they showed an exponential increase with water activity. Situations in which the bulk density was known and unknown were considered. Linear and exponential growth regressions provided equations correlating the dielectric properties with moisture content and water activity with coefficients of determination (r2) higher than 0.96. Analytical expressions of moisture content and water activity in terms of the dielectric properties measured at 8 GHz and 25°C are provided. The standard error of calibration (SEC) was calculated for each calibration equation. Results show that moisture content can be predicted with SECs ranging from 0.41% to 0.68% (w.b.) and water activity with SECs ranging from 0.02 to 0.04 for almond kernel samples with water activity ranging from 0.5 to 0.9 and moisture contents ranging from 4.8% to 16.5% (w.b.). Keywords: Bulk density, Dielectric constant, Dielectric loss factor, Free-space measurements, Loss tangent, Microwave frequencies, Moisture content, Water activity.
Power-Saving Solutions for Pre-Compensated Load-Sensing Systems on Mobile Machines
Authors: Tian Xin , Stump Patrick , Vacca Andrea , Fiorati Stefano , Pintore Francesco 
Published: August 2021

HighlightsTwo methods (VPM and HVM) are proposed to improve the hydraulic system efficiency of agricultural tractors.VPM and HVM both target reducing the power loss at the flow control valve of the hydraulic system.The solutions are presented conceptually and then numerically modeled, and VPM is tested on an actual tractor.Results show that the VPM solution achieves 6.7% power saving, while HVM achieves 15.6% power saving.Abstract. Load sensing (LS) is a dominant fluid power actuation technology in mobile machines, particularly in construction and agriculture. It has the advantage of guaranteeing good controllability in systems with multiple actuators while promoting higher energy efficiency. Several variants of LS systems have been proposed over the years, and research on cost-effective methods to further increase their efficiency is still of interest for original equipment manufacturers (OEMs) and the fluid power community. This article presents two solution, referred to as variable pump margin (VPM) and hybrid variable margin (HVM), suitable to improve the energy efficiency in pre-compensated LS systems such as those used in agricultural tractors. Both methods allow either downsizing the control valves or reducing the power consumption over the working range. Compared to a standard LS system, the VPM solution lowers the pump pressure using an electronic proportional pressure-reducing valve (ep-PRV), while the HVM solution uses a second ep-PRV in the compensator’s pilot line to further minimize the pressure differential across the LS valve. Simulation and experimental results show that, among the main working conditions, the VPM solution on average achieved 6.7% power saving over the standard LS system, while the model predicted an average improvement of 15.6% for the HVM solution. Keywords: Efficiency, Experiments, Hydraulic, Load sensing, Modeling, Pump.
Si isch grösser weder ig! Zum Komparativanschluss im Schweizerdeutschen
Authors: Friedli Matthias 
Published: August 2021

Whereas in Standard High German (SHG) there is only one comparative particle, in Swiss German Dialects (SGD) different lexemes may fulfill the function of a comparative particle:
(1)	SHG:	Sie	ist	grösser	als	ich
SGD:	Si	isch	grösser	als / as / weder / wan / wie	ig
'She	is	bigger	than	me'
The present paper describes the geographical distribution of the comparative particles in the Swiss German area in contexts such as (1). Whereas in some small areas only one comparative particle is found, in the rest of the Swiss German speaking area several competing variants coexist. The data are taken from the third questionnaire of the Syntactic Atlas of Swiss German Dialects, where three different comparative constructions have been investigated. A sociolinguistic analysis of the data reveals differences in the use of the particles: On the one hand, older people tend to use only one comparative particle, whereas younger people show a higher degree of variation. Moreover, older people tend to use the particle weder, in contrast to younger people who tend to use the particle wie. On the other hand, higher educated people use more than one comparative particle, whereas less educated people tend to use one variant only. The analysis of two other constructions also shortly mentioned in the paper shows that syntactic factors have an impact on variant selection, too.
Fluorescence hyperspectral imaging system for analysis and visualization of oil sample composition and thickness
Authors: Xue Qingsheng , Qi Ming , Li Zhanfeng , Yang Bai , Li Wenhao , Wang Fupeng , Li Qian 
Published: August 2021

In this paper, a compact fluorescence hyperspectral imaging system based on a prism-grating-prism (PGP) structure is designed. Its spectrometer spectral range is 400–1000 nm with a spectral resolution of 2.5 nm, and its weight is less than 1.7 kg. The PGP imaging spectrometer combines the technical advantages of prism and grating, by not only using six lenses for imaging and collimation to realize the dual telecentres of object and image but also having a “straight cylinder” structure, which makes the installation and adjustment simple, compact, and stable. By the push-broom method, we obtained the three-dimensional cubic data of different oil products. By normalization processing, minimum noise separation transformation processing, visualization processing, and support vector machine classification processing of different oil fluorescence hyperspectral data, we demonstrate that the fluorescence hyperspectral imaging system can identify different kinds of oil and recognize the oil film thickness. The fluorescence hyperspectral imaging system can be used in oil spill detection, resource exploration, natural disaster monitoring, environmental pollution assessment, and many other fields.
Diffuse photon-remission associated with single-fiber geometry may be a simple scaling of that collected over the same area when under centered-illumination
Authors: Sun Tengfei , Piao Daqing , Yu Linhui , Murari Kartikeya 
Published: August 2021

Robust models for single-fiber reflectance (SFR) are relatively complex [Opt. Lett. 45, 2078 (2020)OPLEDP0146-959210.1364/OL.385845] due to overlapping of the illumination and collection areas that entails probability weighting of the spatial integration of photon-remission. We demonstrate, via analytical means for limiting cases and Monte Carlo simulation of broader conditions, that diffuse photon-remission collected by single-fiber geometry may be scaled over the center-illuminated photon-remission. We specify for a medium revealing Henyey–Greenstein (HG) scattering anisotropy that the diffuse photon-remission from a sub-diffusive area of a top-hat illumination is

∼

84.9

%

of that collected over the same area when under a centered-illumination. This ratio remains consistent over a reduced-scattering fiber-size product of

μ
s
′

d

fib

=
[

10

−
5

,

10

0

]

, for absorption varying 3 orders of magnitude. When applied to hemoglobin oxygenation changes induced in an aqueous phantom using a 200 µm single-fiber probe, the center-illumination-scaled model of SFR produced fitting results agreeing with reference measurements.