bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual presentation of Ramsay‐Hunt Syndrome in kidney transplant patient
Authors: Via Reque Cortes Daniela Del Pilar , Paes Menezes Filho Marcelo , Braga Barbosa Géssica Sabrine , Didier M. Ferreira Tomás , Reusing José Otto , David Neto Elias 
Published: May 2021

AbstractHerpes Zoster (HZ) is caused by reactivation of latent varicella zoster virus (VZV) in craniospinal sensory neurons and is characterized by a painful erythematous rash in the affected dermatome. Although kidney transplant recipients who are chronically maintained on immunosuppressive regimens are considered at risk, there are only a few cases described. We report a well‐documented case of a 50‐year‐old male kidney transplant recipient who presented Ramsay‐Hunt syndrome with atypical neurological finds.
An assessment of the management of anaemia in acute care settings in the United Kingdom: The value of a collaborative approach
Authors: Rampotas Alexandros , Prodger Catherine F. , Murphy Michael F. 
Published: May 2021

AbstractObjectivesPatients presenting to acute care settings with anaemia are at risk of inadequate investigation and inappropriate blood transfusion. In collaboration with Haematology Specialty Trainee Audit and Research (HaemSTAR), this study set out to assess current red blood cell (RBC) transfusion practice and anaemia management in acute care settings across the United Kingdom.Methods and ResultsFifteen different hospitals participated in the study over a period of a month beginning 01 January 2020. Eight‐hundred and twenty‐eight eligible patients presenting to acute care settings with anaemia received RBC transfusions during this period. Of these, 159 (19.2%) received inappropriate transfusions according to National Institute for Health and Care Excellence guidelines, and 257 (31%) could have been treated with alternatives to transfusion. One‐hundred and fifty‐four (18.6%) did not have a cause for their anaemia identified by the time they were discharged from hospital, and in over 50% of these cases that was because of inadequate investigation with blood tests, specialist investigation or referral, or both.ConclusionThis study found that the appropriateness of transfusion and investigation of anaemia in acute care settings warrant improvement and also demonstrates the value of HaemSTAR in facilitating time‐efficient collection of high‐quality data.
Integration of electric, calcium, reactive oxygen species and hydraulic signals during rapid systemic signaling in plants
Authors: Fichman Yosef , Mittler Ron 
Published: May 2021

SUMMARYThe sensing of abiotic stress, mechanical injury or pathogen attack by a single plant tissue results in the activation of systemic signals that travel from the affected tissue to the entire plant. This process is essential for plant survival during stress and is termed systemic signaling. Among the different signals triggered during this process are calcium, electric, reactive oxygen species and hydraulic signals. These are thought to propagate at rapid rates through the plant vascular bundles and to regulate many of the systemic processes essential for plant survival. Although the different signals activated during systemic signaling are thought to be interlinked, their coordination and hierarchy still need to be determined. Here, using a combination of advanced whole‐plant imaging and hydraulic pressure measurements, we studied the activation of all four systemic signals in wild‐type and different Arabidopsis thaliana mutants subjected to a local treatment of high‐light (HL) stress or wounding. Our findings reveal that activation of systemic membrane potential, calcium, reactive oxygen species and hydraulic pressure signals, in response to wounding, is dependent on glutamate receptor‐like proteins 3.3 and 3.6. In contrast, in response to HL stress, systemic changes in calcium and membrane potential depended on glutamate receptor‐like 3.3 and 3.6, while systemic hydraulic signals did not. We further show that plasmodesmata functions are required for systemic changes in membrane potential and calcium during responses to HL stress or wounding. Our findings shed new light on the different mechanisms that integrate different systemic signals in plants during stress.
Focused ultrasound tumour ablation in small animal oncology
Authors: Latifi Max , Hay Alayna , Carroll Jennifer , Dervisis Nikolaos , Arnold Lauren , Coutermarsh‐Ott Sheryl L. , Kierski Katharine R. , Klahn Shawna , Allen Irving C. , Vlaisavljevich Eli , Tuohy Joanne 
Published: May 2021

AbstractThe cancer incidence rates for humans and animals remain high, and efforts to improve cancer treatment are crucial. Cancer treatment for solid tumours includes both treatment of the primary tumour and of metastasis. Surgery is commonly employed to resect primary and metastatic tumours, but is invasive, and is not always the optimal treatment modality. Prevention and treatment of metastatic disease often utilizes a multimodal approach, but metastasis remains a major cause of death for both human and veterinary cancer patients. Focused ultrasound (FUS) tumour ablation techniques represent a novel non‐invasive approach to treating cancer. FUS ablation is precise, thus sparing adjacent critical structures while ablating the tumour. FUS ablation can occur in a thermal or non‐thermal fashion. Thermal FUS ablation, also known as high intensity focused ultrasound (HIFU) ablation, destroys tumour cells via heat, whereas non‐thermal FUS, known as histotripsy, ablates tumour cells via mechanical disintegration of tissue. Not only can HIFU and histotripsy ablate tumours, they also demonstrate potential to upregulate the host immune system towards an anti‐tumour response. The aim of this report is provide a description of HIFU and histotripsy tumour ablation, with a focus on the basic principles of their ablation mechanisms and their clinical applicability in the field of veterinary oncology.
Effects of Bypass Ratio Change Trend on Performance in a Military Aircraft Turbofan Engine With Comparative Assessment
Authors: Akdeniz Halil Yalcin , Balli Ozgur 
Published: May 2021

AbstractIn this study, it is aimed to observe the bypass effects on energetic and exergetic performance in a JT3D-3B Military Aircraft Turbofan Engine and its components. For this aim, the comprehensive energy and exergy analyses are performed separately at the various bypass ratios: BPR: 1.30 (Case A), BPR: 1.34 (Case B), BPR: 1.38 (Case C), BPR: 1.40 (Case D), BPR: 1.42 (Case E), BPR: 1.45 (Case F), and BPR: 1.36 (original design). As per the performance results, while the energetic efficiency of the engine is found to be 27.93% for Case F, 27.85% for Case E, 27.72% for Case D, 27.60% for Case C, 27.17% for Case B, 26.97% for Case A, the exergetic efficiency of the engine is found to be 26.23% for Case F, 26.23% for Case E, 26.11% for Case D, 26.00% for Case C, 25.59% for Case B, and 25.39% for Case A, Furthermore, with the increase of bypass ratio step by step from 1.30 to 1.45, while the energetic efficiency, the exergetic efficiency, the relative exergy consumption value tends to increase, the fuel exergy waste ratio value, the productivity lack ratio, and exergetic improvement potential value of the overall engine tends to decrease. This study can be helpful for turbofan engine users, owners, and designers.
Challenges for Developing and Marketing a Brayton-Cycle-Based Power Genset Gas Turbine Using Supercritical CO2 and a Compressor Design for Simple Recuperated Cycle
Authors: Hosseinpour Javad , Howard Jonathon , Chen Jinbo , Engeda Abraham 
Published: May 2021

AbstractSince the 1960s, the idea of using supercritical carbon dioxide (s-CO2) as the working fluid in a Brayton power cycle has been entertained (Angelino, 1968). But due to technical limitations of the time, the idea did not progress forward much. Presently, due to the availability of more know-how, better technological platform, and advanced analysis tools, many believe it is time to revisit the idea of using s-CO2 as the working fluid for power generation. Among various working fluids, s-CO2 has several significant advantages over other fluids. Primarily, the attractive qualities of s-CO2 are high efficiency, much smaller turbomachinery size and plant footprint (and therefore lower capital cost), and the potential for full carbon capture. However, the realization of these benefits will depend on overcoming several technical, engineering, and materials science challenges. Even though theoretically, the concept is highly attractive and promising, there are yet major hurdles to be passed, namely, the designing, developing, and testing a reasonable size (10 MWe or higher) prototype of a s-CO2 Brayton-cycle-based power gas turbine. This paper reviews the s-CO2 Brayton cycle technologies for power generation and critically assesses the recent challenges and development status. Further, a two-dimensional in-house code was utilized to design an impeller for an s-CO2 simple recuperated Brayton cycle, generating 10-MWe power. The results were validated first with Eckardt’s design which is often referred to as a benchmark due to the most extensive measurements he performed on centrifugal compressors. Then, a centrifugal compressor was designed by the present authors for a simple recuperated cycle, and the results were reported in detail. The results show that the designed compressor has a wide operation range, making it a viable option to be employed for the commercialization purpose of a 10-MWe s-CO2 Brayton cycle.
Flow Continuity of Isothermal Elastohydrodynamic Point-Contact Lubrication Under Different Numerical Iteration Configurations
Authors: Qiu Liangwei , Liu Shuangbiao , Wang Zhijian , Chen Xiaoyang 
Published: May 2021

Abstract
Elastohydrodynamic lubrication (EHL) in point contacts can be numerically solved with various iteration methods, but so far the flow continuity of such solutions has not been explicitly verified. A series of closed regions with the same inlet side boundary is defined, and two treatments to total all flows related to the other boundaries of the closed regions are defined to enable flow-continuity verifications. The multigrid method and the traditional single mesh method with different relaxation configurations are utilized to solve different cases to evaluate computation efficiencies. For the multigrid method, the combination of a pointwise solver together with hybrid-relaxation factors is identified to perform better than other combinations. The single mesh method has inferior degrees of flow continuity than the multigrid method and needs much smaller error control values of pressure to achieve a decent level of flow continuity. Because flow continuity has a physical meaning, its verifications should be routinely included in any self-validation process for any EHL results. Effects of control errors of pressure, mesh sizes, differential schemes, and operating conditions on flow continuities are studied. Then, trends of film thickness with respect to speed are briefly discussed with meshes up to 4097 by 4097.
Onset of Boiling, Heat Transfer, and Flow Patterns of Flow Boiling on the Superhydrophobic Porous Copper Surface in a Microchannel
Authors: Lin Yuhao , Li Junye , Sun Jia , Li Wei , Cao Yanlong 
Published: May 2021

Abstract
To explore the effect of microstructured porous surface on enhancing the heat transfer of flow boiling in a microchannel, the microporous copper surface was fabricated with microscale pores in ranges of 1–5 μm, which presented super-hydrophobicity. Subcooled flow boiling experiments were carried out to study the hydraulic and thermal transport performance in a single narrow rectangular microchannel. High-speed flow visualizations were conducted coupled with instrumental measurements to illustrate the effects of heat flux and mass flux on heat transfer performance and flow patterns for originally hydrophilic bare copper surface and superhydrophobic microporous structured surface. The onset of boiling (ONB) characteristics of both test surfaces was compared with predictive correlations with a good agreement and verified by the captured flow pattern images. Benefit from the superhydrophobic wettability provided by its microscale porous structures and a large number of potential nucleation sites, the required wall superheats, and imposed heat fluxes of onset of boiling both decreased for the modified surface. The flow patterns on the two surfaces varied, which resulted in the different trends of heat transfer coefficient (HTC) with mass fluxes and heat fluxes. Because of the strengthened bubble departure process, the enhancement of the porous surface compared to the original bare surface gradually increased with mass fluxes. The average two-phase heat transfer coefficients of the superhydrophobic porous copper surface were enhanced for up to 74.84%, due to the earlier onset of boiling, higher frequency of bubble nucleation, and strengthened boiling intensity.
More on the unimodality of domination polynomial of a graph
Authors: Lau Gee-Choon , Alikhani Saeid 
Published: May 2021

Let [Formula: see text] be a graph of order [Formula: see text]. A subset [Formula: see text] of [Formula: see text] is a dominating set of [Formula: see text] if every vertex in [Formula: see text] is adjacent to at least one vertex of [Formula: see text]. The domination polynomial of [Formula: see text] is the polynomial [Formula: see text], where [Formula: see text] is the number of dominating sets of [Formula: see text] of size [Formula: see text], and [Formula: see text] is the size of a smallest dominating set of [Formula: see text], called the domination number of [Formula: see text]. Motivated by a conjecture in [S. Alikhani and Y. H. Peng, Introduction to domination polynomial of a graph, ARS Combin. 114 (2014) 257–266] which states that the domination polynomial of any graph is unimodal, we obtain sufficient conditions for this conjecture to hold. Also we study the unimodality of graph [Formula: see text] with [Formula: see text], where [Formula: see text] is an integer.
John Muafangejo’s How God Loves His People All Over the World as Material Religion
Authors: Beyers Jaco , Kriel Lize 
Published: May 2021

Abstract
The artworks produced at the Evangelical Lutheran Church Art and Craft Centre at Rorke’s Drift, KwaZulu-Natal, have been highly appraised and appreciated in South African art-historical circles, not in the least so as African expressions of postcolonial and anti-apartheid resistance. The work of Namibian artist John Muafangejo (1943–1987) is prominent amongst these. In this article, while borrowing generously from the methods of art historical research, our interest is primarily in works of art as objects of material religion. Erwin Panofsky introduced iconology as a way of determining the meaning of art. Iconology wants to enable the seeing of the unseen; seeing the transcendence—making it most applicable to the study of religion as a cultural practice. This article investigates in a critical way how iconology can assist in the study of material religion, especially as applied to the study of religious art. Because meaning is contextual, the conditions under which religious objects are made and interpreted are as important as the work itself. A discussion of a specific work by John Muafangejo originating from the Rorke’s Drift Centre will be conducted by testing the potential of iconology as an analytical tool in this African Christian environment.
Invocation as Self-Change
Authors: Wiley W. Brett 
Published: May 2021

Abstract
George Saunders, who was raised in the Catholic Church and became a Tibetan Buddhist as an adult, incorporates prayer into many of his short stories. Using Catholic and Buddhist definitions and conceptions of prayer, this essay examines prayers in three short stories—“Offloading for Mrs. Schwartz,” “My Flamboyant Grandson,” and “Tenth of December”—and argues that, though Saunders incorporates prayer that formally and content-wise appears Christian, the instances ultimately reflect a Buddhist idea of prayer as a means of self-change and as a practice that affirms the enlightenment of the person praying.
An Implicit Theology of Mad Men
Authors: Hubbard Scott 
Published: May 2021

Abstract
One of the most striking sites of secular-religious encounter in narrative fiction of the decade has been the baptismal imagery of the television serial drama Mad Men. Set in an era which may be said to be the high-water mark of the secularization of American culture, Mad Men’s encoding of meaning in symbolic representation in effect re-sacralizes the secular world into which those symbols are transplanted. The symbolism’s divergences from Christian doctrine and ritual that give Mad Men its distinct theological significance. This paper will explore the literary implications of Paul Ricoeur’s theory of religious symbolism. This paper conducts several close readings of key moments in the show’s use of baptismal symbolism, and offers thoughts about how Mad Men’s constellation of originally religious symbols to convey narrative significance empowers the show to perform a religious function for its audience.
Parathyroid Imaging Practices for Primary Hyperparathyroidism Without Previous Operations Among Endocrine Surgery Program Directors
Authors: Obiarinze Ruth , Chen Herbert , Lindeman Brenessa , Fazendin Jessica , Ramonell Kimberly M. 
Published: May 2021

Background Attempts at preoperative localization of abnormal parathyroid gland(s) in primary hyperparathyroidism (pHPT) can be performed with a variety of modalities. Study utilization is surgeon-specific with highly variable opinions in parathyroid surgery. As more people are diagnosed with pHPT, the complexity of the disease has given rise to variation in management. This heterogeneity raises the question of the true clinical practice of imaging among individual endocrine surgeons. Methods To better understand the preoperative parathyroid imaging practices of endocrine surgeons, an email-based survey was disseminated to the program directors of 22 American Association of Endocrine Surgeons fellowship programs querying them on their initial diagnostic test of choice for pHPT. Clinical support team members from each respective program were subsequently contacted and answers were compared. Results Sixty-eight percent (15/22) of clinical team members recommended either an additional (12/15) or different imaging test (3/15) than what was recommended by their institution’s endocrine surgeon. The most common initial imaging test that was repeated by both the endocrine surgeon and clinical team member was neck ultrasound; 33% of clinical team members (7/22) responded concordantly to their surgeon with ultrasound as the initial recommendation. Discussion Significant variability exists in the preoperative approach to patients with hyperparathyroidism. Here, we demonstrate that inconsistency in preoperative imaging recommendations even extends to within an individual surgeon’s practice based on the impact of the clinical support team, highlighting the role for improved clinical protocols within an institution’s clinical team.
Oropharyngeal Carcinoma Treated with Surgery Alone: Outcomes and Predictors of Failure
Authors: Waltonen Joshua D. , Thomas Sydney G. , Russell Gregory B. , Sullivan Christopher A. 
Published: May 2021

Objective: To analyze the oncologic outcomes and risk factors for recurrence in patients who underwent surgery for oropharyngeal squamous cell carcinoma (OPSCC), and in whom adjuvant therapy was not recommended or was declined. Methods: Retrospective cohort study of patients with OPSCC who were treated with transoral surgery only at a tertiary care academic medical center from April 2010 to March 2019. Results: Seventy-four patients met inclusion criteria. In 16, adjuvant therapy was recommended but declined. There were 8 recurrences, of which 6 had been given recommendations for adjuvant therapy. Of the 8 recurrences, 2 died, 2 are alive with disease, and 4 were successfully salvaged. Five patients died of unrelated causes. Lymphovascular invasion (LVI, P = .016) had a significant impact on recurrence, while other pathologic features of the primary tumor such as size, location, human papillomavirus (HPV) status, and margin status did not. Margins were classified as “positive” in 4 patients, “close” in 54, and “negative” in 16. There were 3 local recurrences (4.1%), each of whom had declined adjuvant therapy. Lymph node features such as N-stage ( P = .0004), number of positive nodes ( P = .0005), and presence of extra-nodal extension (ENE, P = .0042) had a statistically significant impact on relapse. Smoking history and surgical approach showed no significant impact on recurrence. Conclusion: Patients who undergo surgery for HPV-positive OPSCC with negative margins, no PNI, no LVI, and ≤1 positive lymph node without ENE have low risk for recurrence. These patients can likely be safely treated with surgery alone. Patients with these risk factors who decline adjuvant therapy are at risk for recurrence, and should be monitored.
Identification of palliative care needs among people with dementia and its association with acute hospital care and community service use at the end-of-life: A retrospective cohort study using linked primary, community and secondary care data
Authors: Leniz Javiera , Higginson Irene J , Yi Deokhee , Ul-Haq Zia , Lucas Amanda , Sleeman Katherine E 
Published: May 2021

Background: Hospital admissions among people dying with dementia are common. It is not known whether identification of palliative care needs could help prevent unnecessary admissions. Aim: To examine the proportion of people with dementia identified as having palliative care needs in their last year of life, and the association between identification of needs and primary, community and hospital services in the last 90 days. Design: Retrospective cohort study using Discover, an administrative and clinical dataset from 365 primary care practices in London with deterministic individual-level data linkage to community and hospital records. Setting/participants: People diagnosed with dementia and registered with a general practitioner in North West London (UK) who died between 2016 and 2019. The primary outcome was multiple non-elective hospital admissions in the last 90 days of life. Secondary outcomes included contacts with primary and community care providers. We examined the association between identification of palliative care needs with outcomes. Results: Among 5804 decedents with dementia, 1953 (33.6%) were identified as having palliative care needs, including 1141 (19.7%) identified before the last 90 days of life. Identification of palliative care needs before the last 90 days was associated with a lower risk of multiple hospital admissions (Relative Risk 0.70, 95% CI 0.58–0.85) and more contacts with the primary care practice, community nurses and palliative care teams in the last 90 days. Conclusions: Further investigation of the mechanisms underlying the association between identification of palliative care needs and reduced hospital admissions could help reduce reliance on acute care for this population.