bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical effects with customized brackets and CAD/CAM technology: a prospective controlled study
Authors: Hegele Julia , Seitz Lena , Claussen Cora , Baumert Uwe , Sabbagh Hisham , Wichelhaus Andrea 
Published: December 2021

Abstract
Objective
Nowadays, CAD/CAM technologies enrich orthodontics in several ways. While they are commonly used for diagnoses and treatment planning, they can also be applied to create individualized bracket systems. The purpose of this prospective quasi-randomized study was to evaluate the clinical efficiency of a customized bracket system and its comparison with directly bonded conventional self-ligating bracket treatment.

Materials and methods
Altogether 38 patients were separated into two groups, treated either with direct bonded self-ligating brackets (Damon, Ormco, USA) or with indirect bonded customized CAD/CAM brackets (Insignia™, Ormco, USA). Overall treatment time, number of treatment appointments, number of lost or repositioned brackets, number of arch wires and wire bends, Little Irregularity Index, cephalometric analyses and ABO scores were compared. Superimpositions of the virtual set-ups and the treatment results of the CAD/CAM group were performed to evaluate the clinical realization of the treatment planning.

Results
No differences between both treatment groups were found concerning overall treatment time, number of appointments and number of archwire bends. Bonding failures occurred more often using the CAD/CAM system. Indirectly bonded brackets did not have to be repositioned as often as directly bonded brackets. Treatment results with both systems were similar concerning their effects on the reduction of ABO scores. The number of used archwires was higher in the CAD/CAM group. Treatment with both systems led to further proclination of the incisors. Proclination in the lower jaw was greater than proclination in the upper jaw, and there was a statistically significant difference between the two treatment systems. Comparing the treatment results with the virtual set-ups, mesial positions were met best, followed by vertical positions. Transversal positions showed the greatest discrepancies. Concerning angles, values of angulation showed greatest accordance to the virtual set-up, while values of inclinations showed greatest discrepancies.

Conclusion
In comparison with a direct bonded self-ligating bracket system the use of indirect bonded customized CAD/CAM brackets showed only minor influence on treatment efficiency and treatment outcomes. Transversal expansion, deep bite correction, expression of torque and anchorage loss remain challenges in the treatment with straight-wire appliances.
Trial registration DRKS, DRKS00024350. Registered 15 February 2021, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00024350.
MIRS: an imaging spectrometer for the MMX mission
Authors: Barucci Maria Antonietta , Reess Jean-Michel , Bernardi Pernelle , Doressoundiram Alain , Fornasier Sonia , Le Du Michel , Iwata Takahiro , Nakagawa Hiromu , Nakamura Tomoki , André Yves , Aoki Shohei , Arai Takehiko , Baldit Elisa , Beck Pierre , Buey Jean-Tristan , Canalias Elisabet , Castelnau Matthieu , Charnoz Sebastien , Chaussidon Marc , Chapron Fréderic , Ciarletti Valerie , Delbo Marco , Dubois Bruno , Gauffre Stephane , Gautier Thomas , Genda Hidenori , Hassen-Khodja Rafik , Hervet Gilles , Hyodo Ryuki , Imbert Christian , Imamura Takeshi , Jorda Laurent , Kameda Shingo , Kouach Driss , Kouyama Toru , Kuroda Takeshi , Kurokawa Hiroyuki , Lapaw Laurent , Lasue Jeremie , Le Deit Laetitia , Ledot Aurélien , Leyrat Cedric , Le Ruyet Bertrand , Matsuoka Moe , Merlin Frederic , Miyamoto Hideaki , Moynier Frederic , Nguyen Tuong Napoleon , Ogohara Kazunori , Osawa Takahito , Parisot Jérôme , Pistre Laurie , Quertier Benjamin , Raymond Sean N. , Rocard Francis , Sakanoi Takeshi , Sato Takao M. , Sawyer Eric , Tache Fériel , Trémolières Sylvain , Tsuchiya Fuminori , Vernazza Pierre , Zeganadin Didier 
Published: December 2021

AbstractThe MMX infrared spectrometer (MIRS) is an imaging spectrometer onboard MMX JAXA mission. MMX (Martian Moon eXploration) is scheduled to be launched in 2024 with sample return to Earth in 2029. MIRS is built at LESIA-Paris Observatory in collaboration with four other French laboratories, collaboration and financial support of CNES and close collaboration with JAXA and MELCO. The instrument is designed to fully accomplish MMX’s scientific and measurement objectives. MIRS will remotely provide near-infrared spectral maps of Phobos and Deimos containing compositional diagnostic spectral features that will be used to analyze the surface composition and to support the sampling site selection. MIRS will also study Mars atmosphere, in particular spatial and temporal changes such as clouds, dust and water vapor.
Graphical Abstract
Gamma oryzanol niosomal gel for skin cancer: formulation and optimization using quality by design (QbD) approach
Authors: Shah Harsh S. , Gotecha Ankit , Jetha Dolly , Rajput Amarjitsing , Bariya Aditi , Panchal Shital , Butani Shital 
Published: December 2021

AbstractSkin cancer is fifth most diagnosed disease in human population due to ultraviolet radiation (UV) exposure. Gamma oryzanol (OZ) is a natural antioxidant, and it also has skin anti-aging properties. OZ is naturally found in rice bran oil. The main aim of the present work was to optimize OZ niosomal formulation using quality by design approach including one variable at a time and full factorial design. Niosomes were prepared by solvent injection method and characterized for size, polydispersity index, drug entrapment, and transmission electron microscopy. The optimized batch obtained at X1 [drug to span 60 molar ratio (1:5)], X2 [volume of hydration (75 mL)], and X3 [stirring speed (2500 rpm)] to Y1 [average vesicle size (196.6 nm)] and Y2 [entrapment efficiency (78.31%)] as dependent variables. The optimized OZ noisomes were formulated by niosomal gel to provide improved physicochemical stability upon topical application against UV. The niosomal gel was characterized using pH meter, viscometer, Draize test for skin irritancy, ex vivo permeation studies, and stability studies. Ex vivo permeation studies of OZ niosomal gel not only showed fourfold higher permeation but also exhibited better drug retention in dermal layers of skin as compared to OZ gel. Quality Target Product Profile of OZ niosomal formulation was generated. Risk analysis of optimized OZ gel suggested most critical quality attributes (CQAs) and critical process parameters (CPPs) to be characterized as low risk. Thus, γ-oryzanol niosomal gel for topical use can serve as a promising prophylactic treatment in skin cancer, and the developed prototype formulation can be further extended to future newly discovered drugs with similar characteristics.
Graphical abstract
Seizures and epilepsy in patients with ischaemic stroke
Authors: Zöllner Johann Philipp , Schmitt Friedhelm C. , Rosenow Felix , Kohlhase Konstantin , Seiler Alexander , Strzelczyk Adam , Stefan Hermann 
Published: December 2021

Abstract
Background
With the increased efficacy of stroke treatments, diagnosis and specific treatment needs of patients with post-stroke seizures (PSS) and post-stroke epilepsy have become increasingly important. PSS can complicate the diagnosis of a stroke and the treatment of stroke patients, and can worsen post-stroke morbidity. This narrative review considers current treatment guidelines, the specifics of antiseizure treatment in stroke patients as well as the state-of-the-art in clinical and imaging research of post-stroke epilepsy. Treatment of PSS needs to consider indications for antiseizure medication treatment as well as individual clinical and social factors. Furthermore, potential interactions between stroke and antiseizure treatments must be carefully considered. The relationship between acute recanalizing stroke therapy (intravenous thrombolysis and mechanical thrombectomy) and the emergence of PSS is currently the subject of an intensive discussion. In the subacute and chronic post-stroke phases, important specific interactions between necessary antiseizure and stroke treatments (anticoagulation, cardiac medication) need to be considered. Among all forms of prevention, primary prevention is currently the most intensively researched. This includes specifically the repurposing of drugs that were not originally developed for antiseizure properties, such as statins. PSS are presently the subject of extensive basic clinical research. Of specific interest are the role of post-stroke excitotoxicity and blood–brain barrier disruption for the emergence of PSS in the acute symptomatic as well as late (> 1 week after the stroke) periods. Current magnetic resonance imaging research focussing on glutamate excitotoxicity as well as diffusion-based estimation of blood–brain barrier integrity aim to elucidate the pathophysiology of seizures after stroke and the principles of epileptogenesis in structural epilepsy in general. These approaches may also reveal new imaging-based biomarkers for prediction of PSS and post-stroke epilepsy.

Conclusion
PSS require the performance of individual risk assessments, accounting for the potential effectiveness and side effects of antiseizure therapy. The use of intravenous thrombolysis and mechanical thrombectomy is not associated with an increased risk of PSS. Advances in stroke imaging may reveal biomarkers for PSS.
Prognostic significance of microRNA 17–92 cluster expression in Egyptian chronic lymphocytic leukemia patients
Authors: Khalifa M. M. , Zaki N. E. , Nazier A. A. , Moussa M. A. , Haleem R. Abdel , Rabie M. A. , Mansour A. R. 
Published: December 2021

Abstract

Background
Abnormal expression patterns of microRNAs (miRs) play an important role in the development and progression of malignancy. Identification of the clinical significance and prognostic value of these small molecules in chronic lymphocytic leukemia (CLL); a disease of heterogeneous biological landscape and clinical course, has always been of tremendous translational value.

Aim
To evaluate the prognostic value of microRNA17-92 cluster members in Egyptian CLL patients.

Methods
The expression levels of miR17-92 cluster members were evaluated by qRT-PCR, including miR17, miR18a, miR19a, miR19b-1, miR20a, and miR92a-1. Other investigations included serum LDH, serum β2 microglobulin (β2M), CD38 and ZAP70 expression by flow cytometry, fluorescence in situ hybridization (FISH) for 17p deletion, and imaging studies (computerized tomography (CT) scans of neck, chest, abdomen, and pelvis or PET-CT scans).

Results
Overexpression of all members of the miRNA17-92 cluster was detected in CLL patients compared to controls (p =  < 0.001 for all miRs while p = 0.01 for miR19b-1). A significant positive correlation between Hb and miR17 and a significant negative correlation between Hb and miR19b-1 were observed (p = 0.041, 0.017 respectively). A statistically significant positive correlation between miR19b-1 expression and each of the WBCs and absolute lymphocytic count (ALC) was detected (p = 0.023, 0.022 respectively). Moreover, a statistically significant relation between miR19b-1 expression and advanced Binet stages was also found (p = 0.05). Regarding miR18a, a statistically significant positive correlation with LDH level was found (p = 0.003). We also found a significant positive correlation between miR92a-1 and β2M level (p = 0.005), as well as a significant relation between miR17 and negative CD38 expression (p = 0.034). However, no significant relationships between any of studied miRNA expression levels and 17p deletion or response to treatment were observed. Patients who expressed miR19b-1 were significantly indicated to start therapy at diagnosis (p = 0.05). The overall survival of CLL patients included in our study was 90.2% after 1 year from the time of diagnosis. Patients with high expression of miR19a had better OS than those with low expression (p = 0.04).

Conclusions
Overexpression of all members of the miR17-92 cluster was detected in Egyptian CLL patients. MiR18a, miR19b-1, and miR92a-1 also have an adverse prognostic value while miR17 can be considered a good prognostic marker. High expression of miR19a is associated with better OS.
COVID-19 pandemic impact on psychotropic prescribing for adults with intellectual disability: an observational study in English specialist community services
Authors: Naqvi Danial , Perera Bhathika , Mitchell Sarah , Sheehan Rory , Shankar Rohit 
Published: December 2021

BackgroundCoronavirus disease 2019 (COVID-19) has had a disproportionate impact on people with intellectual disability (PwID). PwID are at higher risk of mental illness and receive psychotropic prescribing ‘off licence' also, to manage distress behaviour. The lockdown and reduction of multidisciplinary face-to-face appointments had an impact on care delivery, the recourse possibly being psychotropic prescribing. It is imperative to comprehend the influence the pandemic had on psychotropic prescribing patterns to enable future planning.AimsThe aim was to understand the impact of the pandemic by comparing psychotropic prescribing patterns during the England lockdown with the prescribing patterns before lockdown in specialist urban and rural psychiatric services for PwID.MethodData was collected from Cornwall (rural) and London (urban) intellectual disability services in England as a service evaluation project to rationalise psychotropic prescribing. PwID in both services open across January 2020 to January 2021 were included. Baseline patient demographics including age, gender, ethnicity, intellectual disability level and neurodevelopmental and psychological comorbidities were collected. Baseline psychotropic prescribing and subsequent % change for each psychotropic group for the two services was compared using Pearson's chi-square and z-statistic (two tailed) with significance taken at P < 0.05.ResultsThe two centres London (n = 113) and Cornwall (n = 97) were largely comparable but for baseline differences in terms of presence of severe mental illness (37 v. 86, P < 0.001), challenging behaviour (44 v. 57, P < 0.05) and attention-deficit hyperactivity disorder (37 v. 3, P < 0.001). There was an overall increase in psychotropic prescribing during lockdown in urban as compared with rural settings (11% v. 2%).ConclusionsThe pandemic caused an increase in psychotropic prescribing associated with lockdown severity and urban settings. Team structures could have played a role.
Dual Templating for AFX/LEV Intergrowth Zeolite
Authors: Tsunoji Nao , Gies Hermann , Funase Natsumi , Kolb Ute , Yokoi Toshiyuki , Sadakane Masahiro , Sano Tsuneji 
Published: December 2021

Abstract
Zeolite composed of an intergrowth structure based on AFX and LEV framework types was successfully synthesized by dual-templating strategy using 1,1′-(1,4-butanediyl)bis(1-azonia-4-azabicyclo[2,2,2]octane) and dimethylpiperidinium hydroxides. DIFFaX simulation and 13C NMR results indicated that the AFX framework-type is the main component of the intergrowth structure. The intergrowth material obtained was characterized using XRD, SEM, 27Al and 29Si NMR, and N2 adsorption measurements.
AGÊNCIA LUPA: FACT-CHECKING COMO MODELO DE NEGÓCIO NA INTERNET
Authors: Dourado Jacqueline Lima , Alencar Marta Thaís 
Published: December 2021

Mais de 188 sites especializados em fact-checking em mais de 60 países, conforme o mais recente registro do Duke Reporters' Lab. Desse número, 52% dos verificadores fazem parte de uma organização midiática, enquanto outros integram organizações autônomas, com fins lucrativos. Partindo disso, o presente artigo tem como objetivo analisar a mercantilização das checagens da Agência Lupa para veículos de comunicação, com base na Economia Política do Jornalismo (EPJ), a fim de promover uma reflexão acerca da apuração jornalística que vem sendo realizada por agências independentes com fins lucrativos.
Accuracy of retrieving optical properties from liquid tissue phantoms using a single integrating sphere
Authors: Vincely Vinoin Devpaul , Vishwanath Karthik 
Published: December 2021

Using integrating spheres (ISs) in conjunction with the inverse adding–doubling algorithm (IAD) offers a well-established, rigorous protocol for determining optical absorption (

μ

a

) and reduced scattering (

μ
s
′

) coefficients of thin, optically homogeneous, turbid media. Here, we report the performance and use of a single IS system for experimentally retrieving optical properties in phantom media whose optical properties were well controlled. The IS system was used to measure the total reflectance and transmittance between 500 and 800 nm in liquid phantoms that were prepared to span a wide range of optical scattering and absorption coefficients. Measurements on phantoms were sequentially made using one of two broadband light sources—a halogen lamp or a supercontinuum laser. We report on the accuracy of IAD-derived optical coefficients using IS measurements made on phantoms—directly or by employing one of two previously reported correction methods. The first (sample-substitution error) correction was experimentally achieved while the second used Monte Carlo-based corrections with IAD. When experimentally calibrated reflectance and transmittance values were directly used as inputs to the IAD, mean absolute errors in recovered optical coefficients were larger than

0.4

c
m

−
1

for absorption and more than

6

c
m

−
1

for scattering across all phantoms and wavelengths measured. These errors reduced to

0.06

−

0.17

c
m

−
1

and

0.7

−

2

c
m

−
1

for

μ

a

and

μ
s
′

, respectively, with the use of corrections. Choice of light sources used, sample geometry (relative to optical coefficients), signal-to-noise of measurements, and the selection of correction methods are discussed.
Disturbance location and pattern recognition of a distributed optical fiber sensor based on dual-Michelson interferometers
Authors: Lai Xin , Yu Houdan , Ma Yixiao , Lin Rui , Song Qiuheng , Jia Bo 
Published: December 2021

A distributed fiber optic sensor based on dual-Michelson interferometers for disturbance localization and pattern recognition is proposed. The system obtains the phase difference of each of the two interferometers using a passive demodulating algorithm based on a

3

×

3

coupler. Two correlation signals with disturbance position information are obtained by delaying and subtracting the phase difference signals through which the disturbance location can be obtained. This method has the same frequency response over the whole sensing path, and there is no localization blind spot. The pattern recognition method of this sensing system is to obtain the spectral signal by fast Fourier transform of the demodulated interferometer phase information and input it as a feature vector into a one-dimensional convolutional neural network to verify the correct rate of pattern recognition for four behaviors: stepping, shearing, sweeping, and shaking. The total transmission distance of the system can reach 100 km; the location errors are within

±

35

m

, and the correct rate of four pattern recognitions is higher than 97%. The sensing system has good polarization stability, which can ensure the stability of long-term operation and has a broad application prospect in long-distance perimeter security.
Lösungsorientierte Fragen im Coaching- und Psychotherapie-Gespräch – Ein gesprächslinguistischer Vergleich ihres interaktionstypspezifischen, lokalen Veränderungspotentials
Authors: Kabatnik Susanne , Graf Eva-Maria 
Published: December 2021

ZusammenfassungDer Beitrag thematisiert Lösungsorientierte Fragen (LoF) in Coaching und Psychotherapie aus linguistischer Sicht. Basierend auf gesprächsanalytischen Vorarbeiten wird die Interaktionstypspezifik von Lösungsorientierten Fragen im Coaching und in der Psychotherapie komparativ (re-)analysiert und dokumentiert. Dazu werden die formalen, funktionalen, kontextuellen und Coaching-spezifischen Charakteristika Lösungsorientierter Fragen beschrieben und es wird aufgezeigt, wie LoF zur lokalen Veränderung im Coaching-Gespräch beitragen. Parallel dazu werden diese Ergebnisse mit Erkenntnissen zu Lösungsorientierten Fragen aus dem Beratungsformat Psychotherapie verglichen und die Interaktionstyp-spezifischen Gemeinsamkeiten und Unterschiede vor dem Hintergrund der jeweiligen Handlungsrationale interpretiert. Eine erste Ausdifferenzierung des Fragetyps Lösungsorientierte Fragen für das Beratungsformat Coaching wird vorgeschlagen.
Celebrity culture в системе современных культурных индустрий: особенности производства публичности в структуре новых медиа
Authors: Мерзлякова Виктория Николаевна 
Published: December 2021

Статья посвящена тому, как культура селебрити вписывается в поле культурных индустрий и развивает принципы конвертации различных форм капитала (финансового, социального, культурного). Социальные медиа трансформируют саму идею селебрити, открывая путь для развития публичного позиционирования новых участников. Особый интерес представляют изменения, включающие в круг селебрити тех, кто раньше был в роли участника «из-за кулис» — обеспечивал процесс развития проекта, но выполнял технические и закадровые функции. Появление таких сценариев создает предпосылки для повышения потенциала трансмедийного повествования в развитии проектов в сфере культуры. Так как новая культура селебрити включает также участников, которые раньше (до поворота веб 2.0 технологий) не воспринимались как участники публичного поля, массовой культуры. Сегодня специалисты разных направлений и областей знаний используют алгоритмы развития профессиональной роли «знаменитости» в пиар-деятельности. «Селебрити» больше не является понятием исключительно мира шоу-бизнеса и позволяет говорить об универсальных принципах создания публичной фигуры успешного лидера в различных индустриях и сферах коммуникации. В статье обсуждается, как селебрити-технологии включены в развитие аккаунтов социальных сетей специалистов помогающих профессий: преподавателей, психологов, докторов.
Real-time implementation of Fuzzy Logic Controller based on chicken swarm optimization for the ball and plate system
Authors: Oglah Ahmed A. , Msallam Mohammed Majid 
Published: December 2021

Abstract
The ball and Plate (BaP) system is the typical example of the nonlinear dynamic system that is used in a wide range of engineering applications. So, many researchers in the control field are using the Bap system to check robust controllers under several points that challenge it, such as internal and external disturbances. Our manuscript proposed a position control intelligent technique with two directions (2D) for the BaP system by optimized multi Fuzzy Logic Controllers (FLC’s) with Chicken Swarm Optimization (CSO) for each one. The gains and rules of the FLC’s can tune based on the CSO. This proposal utilizes the ability of the FLC’s to observe the position of the ball. At our work, the BaP system that belonged to Control Laboratory/Systems and Control Engineering department is used for real-time proposal implementation. The results have been showing a very good percentage enhancement in settling time, rise time, and overshoot, of the X-axis and Y-axis, respectively.
Use of algorithms in BIM-based audit processes
Authors: Máder Patrik Márk , Rák Olivér , Bakai Nándor , Etlinger József , Zagorácz Márk , Háber István Ervin 
Published: December 2021

Abstract
Building information modeling is a complex and structure-based methodology. It applies predefined steps and frameworks; however, an audit procedure can be complicated and time-consuming. The steps of the evaluations are based on logical connections that also form algorithms in a manual workflow. Algorithms can be interpreted by computers with the help of software languages. A higher level of automation, more efficient workflows, and more economical and accurate results can be developed by using algorithms.