bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amelioration of Chemical Induced Hepatic Injury by Vitex agnus castus ExtractAmelioration of Chemical Induced Hepatic Injury by Vitex agnus castus Extract
Authors: Ajani Rotimi Sunday , Akpovwovwo Nyerhovwo Abijah , A. Jarikre Theophilus , O. Emikpe Benjamin 
Published: November 2021

Objective: The liver is the major organ of detoxification of ingested materials such as food, beverages and drugs, thus it is prone to toxicity with attendant pathologies. We studied the ability of Vitex agnus castus plant extract to ameliorate the biochemical and structural alterations in Wistar rats with carbon tetrachloride-induced liver injury.
Methods: Forty adult male Wistar rats were allotted into eight equal groups. Group1 was normal control (NC); Group 2 Liver injury without extract (LI). The remaining six groups were paired composite group of varying dosage of the plant extract (200 mg/kg, 400 mg/kg and 600 mg/kg). Only one member of each pair had induced liver injury. Consequently, the groups were Low extract without liver injury (LE), Low extract with liver injury (LEL); Medium extract without liver injury(ME)
Medium extract with liver injury (MEL) and High extract without liver injury (HE),High extract with liver injury (HEL).The biochemical parameters evaluated were the liver function test {Total protein plus globulin and albumen fractions; liver enzymes- alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase}. Oxidative stress was evaluated by measuring the activities of antioxidants namely; Superoxide dismutase (SOD), Catalase, Malondialdehyde (MDA) and Glutathione Peroxidase (GPx).Histology of the harvested liver specimens was used to assess the structural alterations.
Results: The mean liver weight was highest in the HEL group and significantly different from that of its control (HE) and NC.The mean serum total protein of all the groups were significantly higher than that of the NC.The mean aspartate amino transferase levels of the LEL, ME and MEL groups were significantly lower than that of the control while that of the HEL was significantly higher than those of the LEL and MEL. The results of alanine amino transferase were similar to those of aspartate amino transferase. The alkaline phosphatase levels in all the experimental groups were significantly depressed when compared with the control. Amongst the experimental groups, the serum alkaline phosphatase level was significantly raised than those of the LEL, and MEL groups.
The glutathione (GSH) activities of LE, HE and HEL were significantly lower. While the glutathione peroxidase (GPX) activity of the control was significantly lower to those of groups LEL, ME, MEL and HEL.Histopathology of the liver showed preservation of the liver architecture with normal hepatocytes in all the groups.
Conclusion: The ethanolic extract of Vitex agnus castus was able to reduce the severity of carbon tetrachloride induced liver injury in wistar rats.
Comparison Statistical Rice Yield Prediction with Multiple Weather Parameters
Authors: Thurkkaivel T. , Dheebakaran G. A. , Geethalakshmi V. , Patil S. G. , Bhuvaneshwari K. 
Published: November 2021

Advance knowledge of harvestable products, especially essential food crops such as rice, wheat, maize, and pulses, would allow policymakers and traders to plan procurement, processing, pricing, marketing, and related infrastructure and procedures. There are many statistical models are being used for the yield prediction with different weather parameter combinations. The performance of these models are dependent on the location’s weather input and its accuracy. In this context, a study was conducted at Agro Climate Research Centre, Tamil Nadu Agricultural University, Coimbatore during Kharif (2020) season to compare the performance of four multivariate weather-based models viz., SMLR, LASSO, ENET and Bayesian models for the rice yield prediction at Tanjore district of Tamil Nadu State with Tmax, Tmin, Mean RH, WS, SSH, EVP and RF. The results indicated that the R2, RMSE, and nRMSE values of the above models were ranged between 0.54 to 0.79 per cent, 149 to 398 kg/ha, 4.0 to 10.6 per cent, respectively. The study concluded that the Bayesian model was found to be more reliable followed by LASSO and ENET. In addition, it was found that the Bayesian model could perform better even with limited weather parameters and detention of wind speed, sunshine hours and evaporation data would not affect the model performance. It is concluded that Bayesian model may be a better option for rice yield forecasting in Thanjavur districts of Tamil Nadu.
Sero-Prevalence of Dengue Fever Virus Antibodies in Red Sea State, Sudan- A Cross-Sectional Study
Authors: Abbas Israa , Shalabi Manar G. , Abbas Anass M. , Mohamed Hatem , Babker Asaad M. A. , Omer Al Fadhil A. 
Published: November 2021

Background: Dengue fever (DF) is caused by dengue virus (DENV), a positive-sense single stranded RNA virus of the genus Flavivirus in the family Flaviviridae. The DF has been reported as one of the most important arboviral diseases in many parts of the world including Sudan. DENV is a widely spreading disease that has resulted in an emerging infectious disease world-wide.
Aim: The aim of this study was to estimate the prevalence of dengue virus in Red sea state, Sudan.
Materials and Methods: This study is a cross sectional study, carried out in Eastern part of Sudan with an impartial method to determine the DENV antibodies status in Red Sea state, Sudan, Dengue Virus (DENV) antibody test was done for each sample. Blood samples were collected from each patient in a plain container, and then serum was separated and tested for (DENV) IgM by using ELISA.
Results: Of the total 380 dengue cases tested 106 (27.9%) were identified as anti-dengue IgM positive. 57.1% (n=217) were females and 42.9% (n=163) were males, the highest numbers of cases; 152 (40%) from the age group between 40 years and above and least numbers of cases; 47(12.4%) from the age group of 10-19 years. 55 (14.5%) cases among age groups of less than 10 years, 73 (19.2%) from the age group 20-29 years and six 53 (13.9%) from the age group between 30-39 years of age.
Conclusion: We can conclude that serotypes (IgM) of dengue virus prevalence is 27.9% in Red Sea State, Sudan and this finding indicate that the residents of the Red State are at risk of developing the disease. Also, there was significant variation between age and the occurrence of the disease. The Ministry of health should initiate dengue surveillance and commence an integrated vector control programme.
Corticosteroid Resistant Pulmonary Fibrosis: Pathophysiology and Management
Authors: Alghamdi Doha O. , Kawy Hala S. Abdel , Damanhouri Zoheir A. 
Published: November 2021

Pulmonary fibrosis is a disease of the lower respiratory system. It might be as Idiopathic fibrosis which is obscure reason for disease or might be as an optional impact from different causes, for example, the environmental causes, for example, toxins and smoking, some connective tissue illnesses., infection diseases, for example, tuberculosis (TB) and corona virus, a few medications, for example, bleomycin, methotrexate, and radiation treatment. Glucocorticoid are used for treating inflammatory and immune diseases, like asthma, but interstitial lung disease, cystic fibrosis, and chronic obstructive pulmonary disease (COPD) at some stage, may become resistant to corticosteroid treatment. Glucocorticoids inhibit inflammation by many mechanisms. The oxidative stress leads to significantly decrease in activity and expression of Histone deacetylase 2 (HDAC-2) which causes resistant to the action of glucocorticoid. However, the dissociated glucocorticoids have been developed to decrease side effects, the dissociated glucocorticoid receptor agonists (DIGRAs) are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer properties of classical glucocorticoid drugs with fewer side effects, but it is so difficult to dissociate anti-inflammatory effects from adverse effects. Patients with glucocorticoid resistance must use alternative anti-inflammatory treatments as well as drugs that may reverse the molecular mechanism of glucocorticoid resistant. Objective: This paper is to review the corticosteroid resistant pulmonary fibrosis and how overcome this resistance.
The data was collected from December 2020 to September 2021.
Roman Domination of Some Chemical Graphs
Authors: Sangolli Pallavi , Gudgeri Manjula C. , Varsha . , Shirkol Shailaja S. 
Published: November 2021

The concept of Domination in graphs has application to the study of DNA structures. For investigating the chemical and physical properties, several topological indices used are Wiener index, Randic index, Zagreb index, Kier & Hall index that depends on vertex degree and distance sum, and have been used extensively for QSAR and QSPR studies.
A Roman Dominating Function of G is function f: V→ {0, 1, 2} such that every vertex v for which f (v) = 0 has a neighbor u with f(u) = 2. The weight of a Roman dominating function f is w (f) = . The Roman domination number of a graph G is denoted by (G) and is the minimum weight of all possible Roman dominating functions. In this paper, we find Roman domination number of some chemicals graphs such as saturated hydrocarbons and unsaturated hydrocarbons, hexagonal chain, pyrene, Hexabenzocoronene, H-Phenylenic nanotube and N-Napthelenic nanotube.
The moderating role of pessimism in the association between retrospective relational peer victimization, interpersonal risk factors, and suicide ideation
Authors: La Rosa Nikki L. , Brown Sarah L. , Mitchell Sean M. , Seegan Paige L. , Cukrowicz Kelly C. 
Published: November 2021

AbstractPeer victimization (PV) is a serious concern for youth and is associated with subsequent suicide ideation in young adulthood. The interpersonal theory of suicide may provide a framework for understanding suicide ideation in this population. Specifically, thwarted belongingness (TB) and perceived burdensomeness (PB) have been significantly associated with suicide ideation among young adults with a history of peer victimization. Additionally, the personality trait of pessimism is associated with elevated suicide ideation. Thus, this study tested the association between self‐reported frequency of retrospective relational (i.e., verbal and indirect) PV in primary and secondary school, thwarted interpersonal needs (TB and PB), and current suicide ideation, as well as how these relations may vary based on current pessimism. Participants were 330 undergraduate students. Nonparametric bootstrap moderated mediation procedures were used to test hypotheses. Results indicated significant indirect effects of frequency of retrospective relational PV and suicide ideation through PB and TB. Contrary to predictions, results did not indicate significant moderated mediation; however, the association between PB and suicide ideation was stronger at lower pessimism levels. We also provide supplemental analysis with optimism as the moderator. These findings suggest that clinicians may consider targeting TB, PB, as well as pessimism and optimism among those with a history of relational PV when assessing and intervening on current suicide ideation. Implications, limitations, and future directions are further discussed.
Polymer‐Mediated Electron Tunneling Towards Solar Water Oxidation
Authors: Wei Zhi‐Quan , Hou Shuo , Zhu Shi‐Cheng , Xiao Yang , Wu Gao , Xiao Fang‐Xing 
Published: November 2021

AbstractExploiting emerging artificial photosystems with regulated vectorial charge transfer pathways is retarded by the difficulties in precise interface modulation at the nanoscale level, deficiency of suitable assembly methodologies, and ultra‐short charge lifetime. Herein, it is first conceptually demonstrated the general design of transition metal chalcogenides quantum dots (TMCs QDs)‐insulating polymer‐metal oxides (MOs) electron‐tunneling photosystems, wherein TMCs QDs are controllably layer‐by‐layer self‐assembled on the MOs substrates assisted by an ultrathin insulating polymer interim layer. It is ascertained that electrons photoexcited over TMCs QDs in spatially highly ordered MOs/(TMCs QDs/polymer)n multilayered heterostructures can be unidirectionally extracted and tunneled to the MOs substrates across the intermediate insulating polymer layer by engendering the tandem charge transfer to accelerate the interfacial charge migration kinetics, thereby triggering the significantly boosted net efficiency of solar‐driven photoelectrochemical water oxidation. This study would spark new inspirations for designing novel electron‐tunneling photosystems for fine carrier modulation towards solar energy harvesting and conversion.
Formation, Detection, and Function of Oxygen Vacancy in Metal Oxides for Solar Energy Conversion
Authors: Wang Zhiliang , Lin Rijia , Huo Yuning , Li Hexing , Wang Lianzhou 
Published: November 2021

AbstractOxygen vacancy (VO) is one of the most common defects in metal oxides (MOs), which endow the MOs with many unique physiochemical properties. Even though VO engineering has been applied in photo(electro)catalysis, there are still significant challenges in the understanding of the formation, structure, and property of VO. The VO can be produced by treating MOs under low oxygen atmosphere or in vacuum ruled by the equilibrium of VO formation, while other types of defects can also be generated simultaneously. Identifying and distinguishing the formation and function of Vo remain highly challenging, thus the scrutiny of defect formation energy and structure of VO is significant in VO research. This review critically revisits the electronic property and structure changes of MOs upon the generation of Vo. It not only provides clues to detect VO, but also specifies the role of VO in a particular material system considering its drastic influence on light harvesting, conductivity, energy level, surface adsorption, and others. The review also presents a perspective on the future research directions toward rational control of the key aspects of Vo in MOs, namely its formation, characterization, and function, for solar energy conversion.
Tuning the Optical Properties of Au Nanoclusters by Designed Proteins
Authors: Lopez‐Martinez Elena , Gianolio Diego , Garcia‐Orrit Saül , Vega‐Mayoral Victor , Cabanillas‐Gonzalez Juan , Sanchez‐Cano Carlos , Cortajarena Aitziber L. 
Published: November 2021

AbstractGold nanoclusters (AuNCs) are nanomaterials with interesting photoluminescent properties that can be endowed with biomolecular recognition and biocompatibility when stabilized with proteins. The interplay between the optical features of AuNCs and the function added by the protein makes them perfect candidates for generating hybrid protein‐inorganic nanomaterials. Focusing on protein stabilized‐AuNCs, hitherto most of the work has covered the use of natural proteins for in situ growth of AuNCs. However, the exploitation of design proteins for such endeavors enables fine‐tuning of the photoluminescent assets of AuNCs. In this work, rational protein engineering of modular protein scaffolds is applied for capping of non‐emissive, non‐passivated naked AuNCs, resulting in a fast and easy method for the synthesis of customizable and emissive protein‐AuNC nanomaterials. Tuning of the photoluminescent properties of the final hybrid module is obtained by appropriate choice of the coordination residues grafted on the same protein scaffold. The effects of ligands and coordination bonds are studied using time‐resolved photoluminescence and X‐ray absorbance spectroscopies, shedding light on the mechanisms behind the emerging properties of these hybrid materials. Moreover, the described versatile strategy opens new avenues for the synthesis of on‐demand photoluminescent hybrids for a wide spectrum of optical applications.
Molybdenum Diphosphide Nanorods with Laser‐Potentiated Peroxidase Catalytic/Mild‐Photothermal Therapy of Oral Cancer
Authors: Qian Min , Cheng Ziqiang , Luo Guanghong , Galluzzi Massimiliano , Shen Yuehong , Li Zhibin , Yang Hongyu , Yu Xue‐Feng 
Published: November 2021

AbstractChemodynamic therapy (CDT) is an emerging treatment that usually employs chemical agents to decompose hydrogen peroxide (H2O2) into hydroxyl radical (•OH) via Fenton or Fenton‐like reactions, inducing cell apoptosis or necrosis by damaging biomacromolecules such as, lipids, proteins, and DNA. Generally, CDT shows high tumor‐specificity and minimal‐invasiveness in patients, thus it has attracted extensive research interests. However, the catalytic reaction efficiency of CDT is largely limited by the relatively high pH at the tumor sites. Herein, a 808 nm laser‐potentiated peroxidase catalytic/mild‐photothermal therapy of molybdenum diphosphide nanorods (MoP2 NRs) is developed to improve CDT performance, and simultaneously achieve effective tumor eradication and anti‐infection. In this system, MoP2 NRs exhibit a favorable cytocompatibility due to their inherent excellent elemental biocompatibility. Upon irradiation with an 808 nm laser, MoP2 NRs act as photosensitizers to efficiently capture the photo‐excited band electrons and valance band holes, exhibiting enhanced peroxidase‐like catalytic activity to sustainedly decompose tumor endogenous H2O2 to •OH, which subsequently destroy the cellular biomacromolecules both in tumor cells and bacteria. As demonstrated both in vitro and in vivo, this system exhibits a superior therapeutic efficiency with inappreciable toxicity. Hence, the work may provide a promising therapeutic technique for further clinical applications.
Dendrimer‐Like Supramolecular Assembly of Proteins with a Tunable Size and Valency Through Stepwise Iterative Growth
Authors: Bae Jin‐Ho , Kim Hong‐Sik , Kim Gijeong , Song Ji‐Joon , Kim Hak‐Sung 
Published: November 2021

AbstractThe assembly of proteins in a programmable manner provides insight into the creation of novel functional nanomaterials for practical applications. Despite many advances, however, a rational protein assembly with an easy scalability in terms of size and valency remains a challenge. Here, a simple bottom‐up approach to the supramolecular protein assembly with a tunable size and valency in a programmable manner is presented. The dendrimer‐like protein assembly, simply called a “protein dendrimer,” is constructed through a stepwise and alternate addition of a building block protein. Starting from zeroth‐generation protein dendrimer (pG0) of 27 kDa, the protein dendrimer is sequentially grown to pG1, pG2, pG3, to pG4 with a molecular mass of 94, 216, 483, and 959 kDa, respectively. The valency of the protein dendrimers at the periphery increases by a factor of two after each generation, allowing a tunable valency and easy functionalization. The protein dendrimers functionalizes with a targeting moiety and a cytotoxic protein cargo shows a typical feature of multi‐valency in the avidity and a highly enhanced cellular cytotoxicity, exemplifying their utility as a protein delivery platform. The present approach can be effectively used in the creation of protein architectures with new functions for biotechnological and medical applications.
Developing Graphene‐Based Moiré Heterostructures for Twistronics
Authors: Liu Mengya , Wang Liping , Yu Gui 
Published: November 2021

AbstractGraphene‐based moiré heterostructures are strongly correlated materials, and they are considered to be an effective platform to investigate the challenges of condensed matter physics. This is due to the distinct electronic properties that are unique to moiré superlattices and peculiar band structures. The increasing research on strongly correlated physics via graphene‐based moiré heterostructures, especially unconventional superconductors, greatly promotes the development of condensed matter physics. Herein, the preparation methods of graphene‐based moiré heterostructures on both in situ growth and assembling monolayer 2D materials are discussed. Methods to improve the quality of graphene and optimize the transfer process are presented to mitigate the limitations of low‐quality graphene and damage caused by the transfer process during the fabrication of graphene‐based moiré heterostructures. Then, the topological properties in various graphene‐based moiré heterostructures are reviewed. Furthermore, recent advances regarding the factors that influence physical performances via a changing twist angle, the exertion of strain, and regulation of the dielectric environment are presented. Moreover, various unique physical properties in graphene‐based moiré heterostructures are demonstrated. Finally, the challenges faced during the preparation and characterization of graphene‐based moiré heterostructures are discussed. An outlook for the further development of moiré heterostructures is also presented.
High‐Efficiency and Durable Inverted Perovskite Solar Cells with Thermally‐Induced Phase‐Change Electron Extraction Layer
Authors: Li Xin , Meng Yun , Liu Ruizhe , Yang Zhiyao , Zeng Yan , Yi Yuanping , Sha Wei E. I. , Long Yi , Yang Junyou 
Published: November 2021

AbstractReducing carrier recombination and facilitating charge extraction at the interface is of great significance to improve the device performance of perovskite solar cells (PSCs) towards commercial use. However, there has been little work done concerning transportation and recombination mechanism at the interface of the metal electrode and the electron transport layer in inverted PSCs. Herein, a new strategy of interface modification is reported that leverages the unique metal‐to‐insulator transition (MIT) characteristics of vanadium dioxide which is inserted as the electron extraction layer (EEL) in p‐i‐n planar PSCs. Benefiting from the suitable intermediate energy level of VO2, the optimized device shows a power conversion efficiency (PCE) up to 22.11% with negligible hysteresis, as compared to the 20.96% benchmark at room temperature. Interestingly, the PCE of VO2‐based PSC increases to over 23% at 85 °C, which can be attributed to the dramatic change in the electrical properties and better electron extraction caused by the MIT of VO2 beyond its critical phase‐change temperature. In addition, the encapsulated VO2‐PSC shows superior thermal stability for 1000 h at 85 °C under 1 Sun illumination, maintaining over 90% of initial PCE. This work initiates the state‐of‐art concept of inserting thermally‐induced phase‐transition material as an EEL to achieve efficient and durable perovskite photovoltaics.
Introducing rGO@Fe3O4@Ni as an efficient magnetic nanocatalyst for the synthesis of tetrahydrobenzopyranes via multicomponent coupling reactions of dimedone, malononitrile, and aromatic aldehydes
Authors: Esmati Mozhgan , Zeynizadeh Behzad 
Published: November 2021

AbstractIn this study, the synthesis and characterization of the modified GO and rGO@Fe3O4@Ni composite systems were investigated. Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy‐dispersive x‐ray spectroscopy (EDX), x‐ray powder diffraction (XRD), vibrating sample magnetometer (VSM), Brunauer–Emmett–Teller (BET) analysis, thermogravimetric analysis (TGA), and inductively coupled plasma optical emission spectroscopy (ICP‐OES) were employed to characterize the prepared nanomaterials. Also, catalytic activities of GO, rGO@Fe3O4, rGO@Ni, and rGO@Fe3O4@Ni were compared, and rGO@Fe3O4@Ni as the efficient magnetic nanocatalyst was applied to expedite the multicomponent coupling reactions (MCRs) of dimedone, malononitrile, and structurally diverse aromatic aldehydes to prepare tetrahydrobenzopyranes. All reactions were fulfilled efficiently in deionized water under reflux conditions. In addition, sustainability of the nanocatalyst was examined for five consecutive reaction cycles without the significant loss of its catalytic activity.