bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced growth of ginger plants by an eco‐ friendly nitrogen‐fixing Pseudomonas protegens inoculant in glasshouse fields
Authors: Bian Zhilong , Wang Mei , Yang Yan , Wu Yuxia , Ni Haiping , Yu Xu , Shi Jing , Chen Hanna , Bian Xiaoying , Pan Deng , Li Tao , Zhang Youming , Yu Lei , Jiang Lihua , Tu Qiang 
Published: November 2021

AbstractBACKGROUNDExcessive nitrogen (N) fertilization in glasshouse fields greatly increases N loss and fossil‐fuel energy consumption resulting in serious environmental risks. Microbial inoculants are strongly emerging as potential alternatives to agrochemicals and offer an eco‐friendly fertilization strategy to reduce our dependence on synthetic chemical fertilizers. Effects of a N‐fixing strain Pseudomonas protegens CHA0‐ΔretS‐nif on ginger plant growth, yield, and nutrient uptake, and on earthworm biomass and the microbial community were investigated in glasshouse fields in Shandong Province, northern China.RESULTSApplication of CHA0‐ΔretS‐nif could promote ginger plant development, and significantly increased rhizome yields, by 12.93% and 7.09%, respectively, when compared to uninoculated plants and plants treated with the wild‐type bacterial strain. Inoculation of CHA0‐ΔretS‐nif had little impact on plant phosphorus (P) acquisition, whereas it was associated with enhanced N and potassium (K) acquisition by ginger plants. Moreover, inoculation of CHA0‐ΔretS‐nif had positive effects on the bacteria population size and the number of earthworms in the rhizosphere. Similar enhanced performances were also found in CHA0‐ΔretS‐nif‐inoculated ginger plants even when the N‐fertilizer application rate was reduced by 15%. A chemical N input of 573.8 kg ha−1 with a ginger rhizome yield of 1.31 × 105 kg ha−1 was feasible.CONCLUSIONSThe combined application of CHA0‐ΔretS‐nif and a reduced level of N‐fertilizers can be employed in glasshouse ginger production for the purpose of achieving high yields while at the same time reducing the inorganic‐N pollution from traditional farming practices. © 2021 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Bioink Platform Utilizing Dual‐Stage Crosslinking of Hyaluronic Acid Tailored for Chondrogenic Differentiation of Mesenchymal Stromal Cells
Authors: Hauptstein Julia , Forster Leonard , Nadernezhad Ali , Horder Hannes , Stahlhut Philipp , Groll Jürgen , Blunk Torsten , Teßmar Jörg 
Published: November 2021

Abstract3D bioprinting often involves application of highly concentrated polymeric bioinks to enable fabrication of stable cell‐hydrogel constructs, although poor cell survival, compromised stem cell differentiation, and an inhomogeneous distribution of newly produced extracellular matrix (ECM) are frequently observed. Therefore, this study presents a bioink platform using a new versatile dual‐stage crosslinking approach based on thiolated hyaluronic acid (HA‐SH), which not only provides stand‐alone 3D printability but also facilitates effective chondrogenic differentiation of mesenchymal stromal cells. A range of HA‐SH with different molecular weights is synthesized and crosslinked with acrylated (PEG‐diacryl) and allylated (PEG‐diallyl) polyethylene glycol in a two‐step reaction scheme. The initial Michael addition is used to achieve ink printability, followed by UV‐mediated thiol–ene reaction to stabilize the printed bioink for long‐term cell culture. Bioinks with high molecular weight HA‐SH (>200 kDa) require comparably low polymer content to facilitate bioprinting. This leads to superior quality of cartilaginous constructs which possess a coherent ECM and a strongly increased stiffness of long‐term cultured constructs. The dual‐stage system may serve as an example to design platforms using two independent crosslinking reactions at one functional group, which allows adjusting printability as well as material and biological properties of bioinks.
ℵ0‐categorical Banach spaces contain ℓp or c0
Authors: Khanaki Karim 
Published: November 2021

AbstractThis paper has three parts. First, we establish some of the basic model theoretic facts about , the Tsirelson space of Figiel and Johnson [20]. Second, using the results of the first part, we give some facts about general Banach spaces. Third, we study model‐theoretic dividing lines in some Banach spaces and their theories. In particular, we show: (1) has the non independence property
(NIP); (2) every Banach space that is ℵ0‐categorical up to small perturbations embeds c0 or () almost isometrically; consequently the (continuous) first‐order theory of does not characterize , up to almost isometric isomorphism.
Lycopene Regulates Dietary Dityrosine‐Induced Mitochondrial‐Lipid Homeostasis by Increasing Mitochondrial Complex Activity
Authors: Wang Jun , Tang Xue , Lu Yipin , Zheng Yingying , Zeng Fanhang , Shi Wentao , Zhou Peng 
Published: November 2021

ScopeDityrosine (DT), a marker of protein oxidation, is widely found in many high‐protein foods. Dietary intake of DT induces myocardial oxidative stress injury and impairs energy metabolism. Lycopene is a common dietary supplement with antioxidant and mitochondrial‐lipid homeostasis modulating abilities. This study aimed to examine the effects of lycopene on DT‐induced disturbances in myocardial function and energy metabolism.Methods and ResultsFour‐week‐old C57BL/6J mice received intragastric administration of either tyrosine (420 µg kg−1 BW), DT (420 µg kg−1 BW), or lycopene at high (10 mg kg−1 BW) and low (5 mg kg−1 BW) doses for 35 days. Lycopene administration effectively reduced oxidative stress, cardiac fatty acid accumulation, and cardiac hypertrophy and improved mitochondrial performance in DT‐induced mice. In vitro experiments in H9c2 cells showed that DT directly inhibited the activity of the respiratory chain complex, whereas oxidative phosphorylation and β‐oxidation gene expression is upregulated. Lycopene enhanced the activity of the complexes and inhibited ROS production caused by compensatory regulation.ConclusionLycopene improves DT‐mediated myocardial energy homeostasis disorder by promoting the activity of respiratory chain complexes I and IV and alleviates the accumulation of cardiac fatty acids and myocardial hypertrophy.
Breast radiotherapy with kilovoltage photons and gold nanoparticles as radiosensitizer: An in vitro study
Authors: Tudda Alessia , Donzelli Elisabetta , Nicolini Gabriella , Semperboni Sara , Bossi Mario , Cavaletti Guido , Castriconi Roberta , Mangili Paola , Vecchio Antonella del , Sarno Antonio , Mettivier Giovanni , Russo Paolo 
Published: November 2021

PurposeWe investigated the dose enhancement and internalization of gold nanoparticles (AuNPs) used as a radiosensitizer agent for rotational radiotherapy of breast cancer using a kilovoltage (kV) X‐ray beam.MethodsHuman breast cancer cells MDA‐MB‐231 were incubated with or without 100 μg/mL (4.87 nM) or 200 μg/mL (9.74 nM) 15 nm AuNPs and irradiated with 100 kV, 190 kV, or 6 MV X‐rays. To assess the toxicity of the AuNPs, we performed a Sulforhodamine B assay. Using atomic absorption spectroscopy, scanning electron microscopy, transmission electron microscopy, and time‐lapse optical microscopy (rate of 2 frames per minute), we carried out a quantitative assessment of the amount of gold internalized by MDA‐MB‐231 cells and a characterization of the static and dynamical aspects of this internalization process.ResultsNo effect of AuNPs alone was shown on cell viability. Time‐lapse optical microscopy showed for the first time AuNPs cellular uptake and the dynamics of AuNPs internalization. Electron microscopy demonstrated AuNPs localization in endosomal vesicles, preferentially in the perinuclear region. After irradiation at doses up to 2 Gy, cell survival fraction curves showed increased mortality with AuNPs, with respect to irradiation without AuNPs. The highest effect of radioenhancement by AuNPs (at 9.74 nM AuNPs concentration) was observed at 190 kV showing a dose enhancement factor of 1.33 ± 0.06 (1.34 ± 0.02 at 100 kV), while at 6 MV it was 1.14 ± 0.06.ConclusionsThe observed radio‐sensitization effect is promising for future radio‐enhanced kV radiotherapy of breast cancer and quantitatively in the order of previous observations for 15 nm AuNPs. These results of a significant dose enhancement were obtained at 15 nm AuNPs concentration as low as several nanomolar units, at dose levels typical of a single dose fraction in a radiotherapy session. Dynamical behavior of the 3D spatial distribution of 15 nm AuNPs outside the nucleus of single breast cancer cell was observed, with possible implications for future models of AuNPs sensitization.
Big cohort metabolomic profiling of serum for oral squamous cell carcinoma screening and diagnosis
Authors: Yang Xihu , Song Xiaowei , Yang Xudong , Han Wei , Fu Yong , Wang Shuai , Zhang Xiaoxin , Sun Guowen , Lu Yong , Wang Zhiyong , Ni Yanhong , Zare Richard N. , Hu Qingang 
Published: November 2021

AbstractThe survival rate of oral squamous cell carcinoma (OSCC) can be greatly improved if intervention could be initiated as early as possible. This poses a technical demand for developing a sensitive screening and specific in vitro diagnosis method for OSCC. Herewith, a large cohort consisting of 241 healthy contrast (HC) and 578 OSCC patients were recruited for conducting the rapid metabolic profiling of trace volume serum using conductive polymer spray ionization mass spectrometry (CPSI‐MS). Statistical analysis picked out 65 metabolite ions as potential characteristic markers for differentiating OSCC from HC. With the aid of a supporting vector machine (SVM), OSCC can be distinguished from HC with an accuracy of 98.0% by cross‐validation in the discovery cohort and 89.6% accuracy in the validation cohort. Furthermore, orthogonal partial least square‐discriminant analysis (OPLS‐DA) also initially showed the potential for OSCC staging, especially between T1/T2 and T3/T4 stages with an accuracy of 90.1%. CPSI‐MS combined with SVM or OPLS‐DA can not only quickly distinguish OSCC from HC but also predict the OSCC progression from T1/2 to T3/4 stages in a few minutes, making it a promising tool for both screening and diagnosing high‐risk population.Key pointsSixty‐five characteristic metabolite ions significantly changed in OSCC serum metabolic profile compared to that in the HC group.CPSI‐MS combined with SVM achieved 89.6% accuracy on the validation cohort for OSCC prediction.CPSI‐MS/OPLS‐DA can distinguish T1/T2 from T3/T4 stages with an accuracy of 90.1% by cross‐validation.
Increasing teachers' use of behavior specific praise via Apple Watch prompting
Authors: White Kristi R. , Radley Keith C. , Olmi D. Joe , McKinley Lauren E. 
Published: November 2021

AbstractThis study evaluated the effects of a teacher prompting procedure to increase teacher behavior specific praise (BSP) using an Apple Watch. Participants included three Head Start general education teachers. An ABAB design across participants was used to examine the effects of Smart Watch‐based prompts on teachers' praise rate. The study consisted of four phases: (a) baseline, (b) teacher praise training and intervention, (c) withdrawal from intervention, and (d) reimplementation of intervention. Implementation of the intervention was associated with increases in both BSP and general praise for all participating teachers. Although averages did not meet the criterion set by the researcher of one statement per minute, these findings suggest a functional relation between implementation of the procedure and increases in teacher praise.
Face coverings during the pandemic?
Authors: Moyer Rachael M. , Song Geoboo , Jackson Natalie 
Published: November 2021

AbstractThe Health Belief Model (HBM), a value‐expectancy model, is a leading framework in health behavior and communication research. The model is intended to inform targeted communication strategies that promote positive health behaviors. Individual beliefs associated with health risks such as perceived susceptibility and perceived severity are often incorporated into HBM as predictors of health behavior. However, recent studies point to limitations of the current model. At the same time, researchers have successfully used Cultural Theory (CT) to conceptualize, measure, and predict the cultural influences on health risk management. This study applies OLS regression and graphical analysis to examine the relationship between more intrinsic cultural value‐based beliefs and HBM beliefs so as to understand behavioral intentions associated with COVID‐19 among the general public in the United States while statistically controlling for the effects of partisanship and demographic factors.
NNLO virtual and real leptonic corrections to muon-electron scattering
Authors: Budassi Ettore , Carloni Calame Carlo M. , Chiesa Mauro , Del Pio Clara Lavinia , Hasan Syed Mehedi , Montagna Guido , Nicrosini Oreste , Piccinini Fulvio 
Published: November 2021

Abstract
The recently proposed MUonE experiment at CERN aims at providing a novel determination of the leading order hadronic contribution to the muon anomalous magnetic moment through the study of elastic muon-electron scattering at relatively small momentum transfer. The anticipated accuracy of the order of 10ppm demands for high-precision predictions, including all the relevant radiative corrections. The fixed-order NNLO radiative corrections due to the emission of virtual and real leptonic pairs are described and their numerical impact is discussed for typical event selections of the MUonE experiment, by means of the upgraded Monte Carlo code Mesmer.
Risk factors for unsuccessful removal of central venous access ports implanted in the forearm of adult oncologic patients
Authors: Kinoshita Mitsuhiro , Takao Shoichiro , Hiraoka Junichiro , Takechi Katsuya , Akagawa Yoko , Osaki Kyosuke , Ohnishi Norio , Tani Hayato 
Published: November 2021

Abstract
Purpose
To evaluate the risk factors for unsuccessful removal of a central venous access port (CV port) implanted in the forearm of adult oncologic patients.

Materials and methods
This study included 97 adult oncologic patients (51 males, 46 females; age range, 30–88 years; mean age, 63.7 years) in whom removal of a CV port implanted in the forearm was attempted at our hospital between January 2015 and May 2021. Gender, age at removal, body mass index, and diagnosis were examined as patient characteristics; and indwelling period, indwelling side, and indication for removal were examined as factors associated with removal of a CV port. These variables were compared between successful and unsuccessful cases using univariate analysis. Then, multivariate analysis was performed to identify independent risk factors for unsuccessful removal of a CV port using variables with a significant difference in the univariate analysis. A receiver-operating characteristics (ROC) curve was drawn for significant risk factors in the multivariate analysis and the Youden index was used to determine the optimum cut-off value for predicting unsuccessful removal of a CV port.

Results
Removal of CV ports was successful in 79 cases (81.4%), but unsuccessful in 18 cases (18.6%) due to fixation of the catheter to the vessel wall. Multivariate logistic regression analysis showed that the indwelling period (odds ratio 1.048; 95% confidence interval 1.026–1.070; P < 0.0001) was a significant independent risk factor for unsuccessful removal of a CV port. ROC analysis showed that the cut-off value for successful removal was 41 months, and 54% of cases with an indwelling period > 60 months had unsuccessful removal.

Conclusion
The indwelling period is an independent risk factor for unsuccessful removal of a CV port implanted in the forearm of adult oncologic patients, with a cut-off of 41 months.
An Image Quality Comparison Study Between Homemade and Commercial Dental Cone-Beam CT Systems
Authors: Tran Trang Thi Ngoc , Jin David Shih-Chun , Shih Kun-Long , Hsu Ming-Lun , Chen Jyh-Cheng 
Published: November 2021

Abstract
Purpose
Cone-beam computed tomography (CBCT) has been widely applied in dental and maxillofacial imaging. Several dental CBCT systems have been recently developed in order to improve the performance. This study aimed to evaluate the image quality of our prototype (YMU-DENT-P001) and compare with a commercial POYE Expert 3DS dental CBCT system (system A).

Methods
The Micro-CT Contrast Scale, Micro-CT Water and Micro-CT HA phantoms were used to evaluate the two CBCT systems in terms of contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), uniformity (U), distortion, and linearity in the relationship between image intensity and calcium hydroxyapatite concentration. We also fabricated a proprietary thin-wire phantom to evaluate full width at half maximum (FWHM) spatial resolution. Both CBCT systems used the same exposure protocol, and data analysis was performed in accordance with ISO standards using a proprietary image analysis platform.

Results
The SNR of our prototype system was nearly five times higher than that of system A (prototype: 159.85 ± 3.88; A: 35.42 ± 0.61; p < 0.05) and the CNR was three times higher (prototype: 329.39 ± 5.55; A: 100.29 ± 2.31; p < 0.05). The spatial resolution of the prototype (0.2446 mm) greatly exceeded that of system A (0.5179 mm) and image distortion was lower (prototype: 0.03 mm; system A: 0.285 mm). Little difference was observed between the two systems in terms of the linear relationship between bone mineral density (BMD) and image intensity.

Conclusions
Within the scope of this study, our prototype YMU-DENT-P001 outperformed system A in terms of spatial resolution, SNR, CNR, and image distortion.
Non-CG DNA methylation-deficiency mutations enhance mutagenesis rates during salt adaptation in cultured Arabidopsis cells
Authors: Zhu Xiaohong , Xie Shaojun , Tang Kai , Kalia Rajwant K. , Liu Na , Ma Jinbiao , Bressan Ray A. , Zhu Jian-Kang 
Published: November 2021

AbstractMuch has been learned about how plants acclimate to stressful environments, but the molecular basis of stress adaptation and the potential involvement of epigenetic regulation remain poorly understood. Here, we examined if salt stress induces mutagenesis in suspension cultured plant cells and if DNA methylation affects the mutagenesis using whole genome resequencing analysis. We generated suspension cell cultures from two Arabidopsis DNA methylation-deficient mutants and wild-type plants, and subjected the cultured cells to stepwise increases in salt stress intensity over 40 culture cycles. We show that ddc (drm1 drm2 cmt3) mutant cells can adapt to grow in 175 mM NaCl-containing growth medium and exhibit higher adaptability compared to wild type Col-0 and nrpe1 cells, which can adapt to grow in only 125 mM NaCl-containing growth medium. Salt treated nrpe1 and ddc cells but not wild type cells accumulate more mutations compared with their respective untreated cells. There is no enrichment of stress responsive genes in the list of mutated genes in salt treated cells compared to the list of mutated genes in untreated cells. Our results suggest that DNA methylation prevents the induction of mutagenesis by salt stress in plant cells during stress adaptation.
Against Intuitive Horribleness
Authors: Reynolds Joel Michael 
Published: November 2021

AbstractTestimony by disabled people concerning the relationship between their experiences and overall well-being has long been an object of social scientific and humanistic study. Often discussed in terms of “the disability paradox,” these studies contrast the intuitive horribleness of certain impaired states against the testimonial evidence suggesting that people in such states do not in fact experience their lives as horrible. Explanations for why such testimonial evidence is suspect range from claims about adaptive preferences to issues of qualitative research methodology. In this paper, I argue that the problem lies not with the evidence, but the intuitions in question. Using the disability paradox as a case study, I further argue against the use of the concept of intuitive horribleness in social epistemology. I contend that testimonial and hermeneutical injustices are baked into most deployments of the concept, and even if one were to justify its use in select cases, it should be accompanied with prima facie suspicion. In conclusion, I discuss the implications of this analysis for the literature on transformative experience and also for the stakes of multi-cultural, historically informed philosophical analyses more generally.
Efficacy of bio- and neurofeedback for depression: a meta-analysis
Authors: Fernández-Alvarez J. , Grassi M. , Colombo D. , Botella C. , Cipresso P. , Perna G. , Riva G. 
Published: November 2021

AbstractBackgroundFor many years, biofeedback and neurofeedback have been implemented in the treatment of depression. However, the effectiveness of these techniques on depressive symptomatology is still controversial. Hence, we conducted a meta-analysis of studies extracted from PubMed, Scopus, Web of Science and Embase.MethodsTwo different strings were considered for each of the two objectives of the study: A first group comprising studies patients with major depressive disorder (MDD) and a second group including studies targeting depressive symptomatology reduction in other mental or medical conditions.ResultsIn the first group of studies including patients with MDD, the within-group analyses yielded an effect size of Hedges' g = 0.717, while the between-group analysis an effect size of Hedges' g = 1.050. Moderator analyses indicate that treatment efficacy is only significant when accounting for experimental design, in favor of randomized controlled trials (RCTs) in comparison to non RCTs, whereas the type of neurofeedback, trial design, year of publication, number of sessions, age, sex and quality of study did not influence treatment efficacy. In the second group of studies, a small but significant effect between groups was found (Hedges' g = 0.303) in favor of bio- and neurofeedback against control groups. Moderator analyses revealed that treatment efficacy was not moderated by any of the sociodemographic and clinical variables.ConclusionsHeart rate variability (HRV) biofeedback and neurofeedback are associated with a reduction in self-reported depression. Despite the fact that the field has still a large room for improvement in terms of research quality, the results presented in this study suggests that both modalities may become relevant complementary strategies for the treatment of MDD and depressive symptomatology in the coming years.
Exploring the contribution of housing adaptations in supporting everyday life for people with dementia: a scoping review
Authors: Newton Rita , Adams Sue , Keady John , Tsekleves Emmanuel 
Published: November 2021

AbstractThe primary aim of this scoping review was to explore the contribution of housing adaptations to supporting everyday life for people with dementia living at home in the community. The study adopted a scoping review methodology which was guided by the Joanna Briggs Institute Reviewers Manual. Four review questions were developed which subsequently informed the inclusion criteria and search terms. Eight databases were searched resulting in 2,339 records, with 13 papers being included in the review. Evidence from the review found that the most common adaptations were recommended and/or implemented to compensate for a person's physical limitations and for safety reasons, rather than adaptations to support activities of daily living for a person with dementia. Support to implement adaptations was provided by a range of professionals coupled with ‘trial and error’ approaches adopted by the person themselves, and these were seen as key enablers. Barriers to implementing and using adaptations were fourfold: (a) access to information, (b) knowing when to make changes, (c) carer resistance, and (d) the unsuitability of the home. It would appear that housing adaptations have a positive impact on both the person with dementia and the carer (where one is present), with some adaptations having a relatively sustained impact and being particularly effective if implemented early in the lived trajectory of dementia.