bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo Characterization of Biochemical Variants of Amyloid-β in Subjects with Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease Neuropathological Change
Authors: Libard Sylwia , Walter Jochen , Alafuzoff Irina 
Published: February 2021

Background: Stepwise occurrence of biochemically modified amyloid-β (Aβ) in the brain of subjects with Alzheimer’s disease (AD) has been suggested to be of significance for cognitive impairment. Our previous reports have shown that Aβ is observed in 63% of all subjects with idiopathic normal pressure hydrocephalus (iNPH) suggesting that the majority of iNPH subjects with Aβ are indeed also suffering from AD. Objective: We assessed the occurrence of biochemically modified Aβ variants, in vivo, in subjects with iNPH and in a cohort of postmortem brain samples from patients with dementia. Methods: We assessed Aβ proteins in 127 diagnostic brain biopsies obtained from subjects with iNPH and in a cohort of subjects with dementia by means of immunohistochemistry. Results: The pyroglutamylated Aβ (pyAβ) precedes the aggregation of phosphorylated Aβ (pAβ) during the AD neuropathological change progression; moreover, these modified variants of Aβ correlate with hyperphosphorylated tau in the frontal cortical area of human brain. Our results confirm the existence of the suggested biochemical stages of Aβ aggregation that might be of significance for neurodegeneration leading to cognitive impairment. Conclusion: The observation that both pyAβ and pAβ are seen in vivo in iNPH subjects is intriguing. It has been reported that most of the iNPH subjects with Aβ in the brain biopsy indeed develop AD with time. Based on our current and previous results, it is clinically merited to obtain a diagnostic biopsy from a subject with iNPH. When Aβ is observed in the biopsy, the biochemical characterization is of interest.
Protection against COVID-19 in African population: Immunology, genetics, and malaria clues for therapeutic targets
Authors: Altable Marcos , de la Serna Juan Moisés 
Published: February 2021

Background: There is a marked discrepancy between SARS-CoV-2 seroprevalence and COVID-19 cases and deaths in Africa.

Main: SARS-CoV-2 stimulates humoral and cellular immunity systems, as well as mitogen-activated protein kinase (MAPK) and nuclear NF-kB signalling pathways, which regulate inflammatory gene expression and immune cell differentiation. The result is pro-inflammatory cytokines release, hyperinflammatory condition, and cytokine storm, which provoke severe lung alterations that can lead to multi-organ failure in COVID-19. Multiple genetic and immunologic factors may contribute to the severity of COVID-19 in African individuals when compared to the rest of the global population. In this article, the role of malaria, NF-kB and MAPK pathways, caspase-12 expression, high level of LAIR-1-containing antibodies, and differential glycophorins (GYPA/B) expression in COVID-19 are discussed.

Conclusion: Understanding pathophysiological mechanisms can help identify target points for drugs and vaccines development against COVID-19. To our knowledge, this is the first study that explores this link and proposes a biological and molecular answer to the epidemiologic discrepancy in COVID-19 in Africa.
PROSPECTIVE ANALYSIS OF IMPACT OF PHARMCOTHERAPY ADHERENCE ON TREATMENT EFFECTIVENESS IN POST OPERATIVE HEART PATIENTS
Authors: Khandelwal Samridhi , Sharma Vandana , Pareek Ramesh , Tripathi Shailendra , Soni Shankar , Upadhyay Pawan 
Published: February 2021

Myocardial infarction is the irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. This most commonly occurs when a coronary artery becomese blocked following the rupture of an atherosclerotic plaque, which then leads to the formation of a blood clot (coronary thrombosis). This event can also trigger coronary vasospasm. Ischemia induces profound metabolic and ionic perturbations in the affected myocardium and causes rapid depression of systolic function. Prolonged myocardial ischemia activates a "wavefront" of cardiomyocyte death that extends from the subendocardium to the subepicardium. Mitochondrial alterations are prominently involved in apoptosis and necrosis of cardiomyocytes in the infarcted heart.
This prospective, pilot, observational study performed confirmed the hypothesis that systematic identifications and interventions administered through continued physician follow-up and patients counselling will improve adherence to therapy and therefore improvement in treatment effectiveness by lowering especially Troponin level ,CPK and quality of life in MI patients.
Study was shown that lack of proper knowledge about disease and patients counseling and chronic treatment, most of patients takes disease and its treatment lightly and shows lower adherence attitude. The study analysis shown that female are generally more aware than males for adherence. Study analysis concluded that there was significant reduction in their Troponin level and CPK values in different comparison groups after each level of follow up.
Statistical analysis concluded that patients with adherence ˃ 95% showed significant reduction in Troponin level and CPK values and patients with age group ≤50 shows more adherence than older.
Most heart patients recorded with hypertension and Coronary Artery Diseases only few ones with diabetic complications. During study patients shows good control over their blood pressure and only few adverse events but no complications occur during study period.
A szénhidrogén-feldolgozás káreseményeihez kapcsolódó tűzvizsgálati tevékenység fejlesztési lehetőségei – 2. rész
Authors: Tóth András , Bleszity János , Restás Ágoston 
Published: February 2021

A tűzvizsgálati tevékenység fontos része a katasztrófavédelem komplex rendszerének, a feltárt tűzkeletkezési okok és a megszerzett tapasztalatok visszahatnak a tűzvédelemre, az iparbiztonságra és a polgári védelemre. A szerzők hipotézise, hogy a szénhidrogén- feldolgozás során keletkezett tüzek vizsgálata merőben más szemléletet kíván, mint az élet különféle területein lefolytatott tűzvizsgálatok. A 2. rész a fejlesztési lehetőségeket, a technikai újdonságokat, a tűztáblázat használhatóságát és a szénhidrogén-feldolgozás káreseményeinek tűzvizsgálatához alkalmazható kiterjesztett valóságot vizsgálja.
Integrated Nutrient Management on Panikachu in Joypurhat
Authors: Akther MA , Hasan T , Mollah M RA , Rahman MH , Islam MA 
Published: February 2021

An experiment was conducted at the Multi location Testing (MLT) site, (medium highland under AEZ-25) Pachbibi, Joypurhat, Bogura district during rabi season of 2015-16. In the study, to evaluate the response of panikachu to different nutrient management practices under farmer’s field condition. There were five treatments viz. T1=Soil test based fertilizer dose (FRG 2012), T2=T1+ 25% NPK, T3=IPNS with 3 tha-1 poultry manure, T4= IPNS with 5 tha-1 cowdung, and T5= Farmers practice. The experiment was laid out in randomized complete block design (RCBD) with six dispersed replications.T3= IPNS with 3 t ha-1 poultry manure, T4 = IPNS with 5 t ha-1 cowdung, and T5= Farmers practice. The highest Panikachu rhizome yield (21.71 t ha-1), gross return (TK. 430185ha-1) and BCR (3.61) were found from T3 (IPNS with 3 t ha-1 poultry manure) which was followed by T5 (19.66 tha-1) T4 (19.45 tha-1), and statistically differed to other treatments. However, from results, it could be recommended that IPNS will be a promising technology for higher crop yields of Panikachu and profit as well as for the improvement of soil fertility and sustain soil productivity in Joypurhat region.
Environ. Sci. & Natural Resources, 12(1&2): 29-32, 2019
Heritability and Genetic Advance Estimates from the Parental Lines of Hybrid Maize (Zea Mays L.)
Authors: Biswas T , Islam MS , Methela NJ 
Published: February 2021

Twenty-two genotypes of maize parental line were grown during 2017-2018 at the Research field of Plant Breeding Division, Regional Agricultural Research Station (RARS), Bangladesh Agricultural Research Institute (BARI), Rahmatpur, Barisal, Bangladesh. The experiment was laid out in randomized complete block design with three replications. Heritabilty, coefficients of variability and genetic advance values were computed for days to tasseling, days to silking, days to maturity, plant height (cm), ear height (cm), cob length (cm) and diameter (cm), number of seed rows per cob, number of seeds per row, number of seeds per cob, thousand grain weight (g) and yield (g/plant). Among all the traits higher phenotypic coefficient of variation (44.53) and genotypic coefficient of variation (44.18) were observed for yield/plant. The uppermost heritability was observed in case of yield per plant (98.41) followed by 1000 seed weight (96.91). Genetic advance was highest for seeds/cob (197.87) followed by 1000-kernel weight (176.86).Greater magnitude of heritability coupled with higher genetic advance in characters under study provided the evidence that these plant parameters were under the control of additive genetic effects. Indicating that selection should lead to a fast genetic improvement of the material.
Environ. Sci. & Natural Resources, 12(1&2): 33-36, 2019
Contamination Status of Surface Water from the Balu River for Irrigation Usage in Bangladesh
Authors: Arefin MT , Rahman MM 
Published: February 2021

An attempt was made to evaluate the contamination status of surface water collected from the Balu river for irrigation. Twenty samples were collected to analyze pH, EC, TDS and ions. Samples were slightly alkaline in nature. Water samples were from low to medium salinity and low alkalinity hazards (C1S1-C2S1). As per TDS values, samples were classified as freshwater. Considering SAR and SSP values, samples were excellent and good to permissible classes, respectively. Most of the water samples were free from RSC and all the samples were under moderately hard. The status of Cr and Mn ions in samples surpassed FAO guideline values indicating contaminants for long-term irrigation. The levels of other metal ions in samples were within acceptable levels and did not pose a threat to irrigated soil. This finding revealed that Cr and Mn ions were considered as contaminants in river water for irrigation posing harmful impact on soils and crops.
Environ. Sci. & Natural Resources, 12(1&2): 57-65, 2019
Status of Farming and Marketing of Live Pangas (Pangasius hypophthalmus) from Trishal Upazila to Different Areas of Bangladesh
Authors: Hossain MI , Shikha FH , Ahmmed F 
Published: February 2021

The research was conducted to collect information on the status of farming and marketing of live pangas (Pangasius hypophthalmus) from Trishal region to different areas of Bangladesh by interviewing stakeholder and secondary sources. The survey was carried out for seven months from May to November, 2016. Pangas farmers, arotdar, commission agents, wholesaler and retailers were interviewed in accordance with participatory rural methods. The results showed that the best harvesting season were found to be June to July and November to January. It was also found that 90% farmers harvested their fish completely and only 10% of farmers harvested partially. The price of pangas depends on market structure, quality, size, distance, weight, seasonal variation and regional perception. The prices of pangas were found to be highest of 130tk/kg and the lowest of 85tk/kg but sometimes 60 to 70tk/kg when the fish are dead (on the way to destined area) in different districts. On the other hand significant quantity loss was observed in fish 8%, 10%, 15%, 18%, and 19% after reaching to Savar, Manikgonj, Maowa, Sylhet, and Barisal from Trishal. Therefore, it was strongly recommended that proper handling of live fish must be ensured during transportation to attain quality pangas at consumer level.
Environ. Sci. & Natural Resources, 12(1&2): 73-82, 2019
Geomorphological Study of Jaflong Area near Dauki Fault Using Remote Sensing and Geographic Information System
Authors: Salam MA , Tazneen F , Chowdhury ASMN 
Published: February 2021

Geomorphology is closely related to geology, soil science, hydrology and environmental science and is being increasingly applied in planning, mining and hydrological sectors, and within environmental consultancy and tourism. The study area lies in the north-eastern part of the country and tectonically this area belongs to Surma Basin situated into Bengal Fore deep zone of Bengal Basin also known as Sylhet Trough. Under this study an attempt was made to establish the relationship between geomorphic unit and existing landuse based on remote sensing data. In the study area nine landuse categories were identified through remote sensing and GIS techniques. Two different physiographic units which are North-Eastern Terrace Land and Surma-Kushiyara Flood Plain are belongs to the study are. Moreover two surface geological units include Young Gravelly Sand and Marsh Clay and Peat are also there. From analysis no relationship has been found between landuse classes with its physiography and surface geology.
Environ. Sci. & Natural Resources, 12(1&2): 151-155, 2019
Quality Assessment of Smoked Shrimps (Traditional and Improved)Stored at Room Temperature (28 To 32°C) in Different Packs
Authors: Hossain MI , Shikha FH , Mursalin MS 
Published: February 2021

To preserve shrimps, smoking or smoke curing is an ancient methods in practice since long before. The present study was conducted to prepare improved smoked shrimp from 4 different species of raw shrimps, namely Chali (Metapenaeus brevicornis), Chaka (Penaeus indicus), Horina (Metapenaeus monoceros) and Khogda (Parapenaeopsis stylifera) at laboratory condition, to observe the changes in sensory, biochemical and microbiological parameters of the both laboratory and traditionally prepared (at Koyra, Khulna) smoked shrimps of these species. The initial moisture level of improved smoked shrimps (Chali, Chaka, Horina and Khogda) ranged from 14.22±0.02%~16.15±0.03% with the highest value in Khogda, but the moisture content of traditional smoked Chali was 17.53±0.11%. After storage of 120 days the moisture reached to the ranged from 15.12±0.13% to 18.83±0.21%, protein content from initial 61.18± 91%~64.05±0.41% to 52.8 ±51%~57.61±0.84%, lipid content from initial 9.73±0.06%~10.05± 0.06% to 8.55±0.04%~9.10±0.06% and ash contents from initial 11.06±0.14%~16.36±0.08% to 14.28±0.08%~19.11±0.07%. For TVB-N values and microbial load also a same increasing trend was observed for the samples. From the obtained results of the study it could be concluded as- implementation of improved techniques for smoking able to extend the storage period of smoked shrimps and among different packs vacuum sealed pack is the most effective one for storage.
Environ. Sci. & Natural Resources, 12(1&2): 181-190, 2019
Drinking Water Supply Options in Arsenic and Salinity Affected Areas of Bangladesh: A Case Study
Authors: Rahman MA , Ali MA , Ahmed T , Habib ME , Hossain MS 
Published: February 2021

Widespread groundwater arsenic contamination in south, south-western and north-eastern regions and high salinity in the south-western coastal region are the two major challenges for drinking water supply in Bangladesh. In this study, we assessed various water supply technologies used for mitigating arsenic and salinity in Laksam of Cumilla and Assasuni of Satkhira district. Water samples were analyzed for Arsenic, Iron, Chloride (indicator for salinity) and FC from different water extraction systems (shallow, deep and Tara tubewells), groundwater arsenic treatment units (SIDKO and READ-F), rainwater harvesting systems (RWH), pond sand filters (PSF), and managed aquifer recharge units. Most shallow tubewells, both in Laksam and Assasuni, have been found to produce arsenic contaminated water. But water from deep and Tara tubewells have been found arsenic-free, though high concentration of iron was observed in the wells in Laksam. Rainwater harvesting systems, PSF and MAR units in Assasuni have been found to provide water free from the common chemical contaminants but suffer from high bacterial contamination. Deep tubewell appear to be the most preferred option where a suitable aquifer is available. The community-scale groundwater treatment systems would require strong operation and maintenance support from the service providers to be successful.
Environ. Sci. & Natural Resources, 12(1&2): 215-223, 2019
Manganese as a Micronutrient in Agriculture: Crop Requirement and Management
Authors: Rashed MH , Hoque TS , Jahangir MMR , Hashem MA 
Published: February 2021

Manganese (Mn) as an essential plant micronutrient affects plant development, when at deficient or toxic levels. Manganese is used in several biological processes as an important contributor in plant growth and development. Manganese uptake depends on forms of Mn in soil solution, crop characteristics including growth rate, and ineteractions with other environmental factors. Its distribution in soils and requirement for crops vary from location to location, depending on soil type and reactions. Despite the metabolic roles of Mn in different plant cell compartments, the importance of Mn requirement in plants, distribution in soils and application to crops has been understated. As a micronutrient, judicious Mn management requires to critically evaluating its concentration in soils, biochemical functions, critical levels, soil availability and interactions with other nutrient elements is essential. This review has critically analysed the existing body of knowledge on Mn distribution in soils, dynamics, functions and management towards better crop production and safe environment.
Environ. Sci. & Natural Resources, 12(1&2): 225-242, 2019
PENDAMPINGAN PELATIHAN SOFTWARE APLIKASI GUNA PERSIAPAN LKS DI SMK MUHAMMADIYAH SALAM
Authors: Artha Emilya Ully 
Published: February 2021

Abstract: Community service activities carried out at Muhammadiyah Salam Vocational School (SMK Muhammadiyah Salam), Salam Subdistrict, Magelang Regency so that the X grade (1st) students of Muhammadiyah Salam Vocational School can support computer creativity specifically for desktop applications for developing Software Engineering (RPL) skills. This service activity is carried out by using a method of mentoring for class X students through computer assistance / application programs such as database and desktop creation. The long-term goal is the preparation of class X students who have an interest in application software to participate in the Student Skills Competition (LKS) in the following period. This application software training at Muhammadiyah Vocational School does not have an RPL major, so students are selected to take part in this activity. The final output that will support this activity is student assistance in computer applications as a development aid for students in the field of programming / software engineering. In addition, the publication of the results of this service was in the community service journal Keywords: Community Service, Software Engineering, Application Software, Programming Abstrak: Kegiatan pengabdian masyarakat yang dilakukan di SMK Muhammadiyah Salam, Kecamatan Salam Kabupaten Magelang bertujuan agar para siswa kelas X SMK Muhammadiyah Salam dapat memiliki kreatifitas pada bidang komputer khususnya aplikasi desktop untuk pengembangan ketrampilan Rekayasa Perangkat Lunak (RPL). Kegiatan pengabdian ini dilaksanakan dengan menggunakan metode pendampingan secara komprehensif kepada pada siswa kelas X melalui pendampingan program/aplikasi komputer seperti pembuatan database dan desktop. Tujuan jangka panjangnya adalah mempersiapkan siswa kelas X yang mempunyai minat di bidang software aplikasi untuk mengikuti kegiatan Lomba Kompetensi Siswa (LKS) pada periode berikutnya. Pelatihan software aplikasi ini karena di SMK Muhammadiyah tidak memiliki jurusan RPL, sehingga mahasiswa diseleksi untuk mengikuti kegiatan ini. Luaran akhir yang akan dicapai dari kegiatan ini adalah meningkatnya kemampuan siswa dalam penggunaan aplikasi komputer sebagai alat pengembangan kreatifitas siswa dalam bidang pemrograman/rekayasa perangkat lunak. Selain itu adalah terpublikasinya hasil pengabdian ini dalam jurnal pengabdian masyarakat. Kata kunci: Pengabdian Masyarakat, Rekayasa Perangkat Lunak, Software Aplikasi, Pemrograman
SOSIALISASI FILM ANIMASI 2D VECTOR DAMPAK BENCANA ALAM DI INDONESIA DENGAN NILAI-NILAI ISLAMI
Authors: Yuliati Tri , Alimudin Erna 
Published: February 2021

Program Pengabdian pada Masyarakat (PPM) yang dilaksanakan bertujuan untuk menerapkan multimedia sebagai media pembelajaran. Media pembelajaran yang dibuat adalah film animasi 2D Vector dengan latar cerita bencana alam di Indonesia (tsunami, gunung merapi, dan longsor) dengan nilai-nilai islami di dalamnya. Pemutaran film animasi ini membuat anak-anak menjadi lebih mudah untuk memahami musibah dalam bentuk bencana alam seperti apa dan sikap bagaimana yang perlu diambil sebagai seorang muslim. Anak-anak pun termotivasi senantiasa mengingat doa yang sudah diajarkan di Tempat Pembelajaran Quran (TPQ). Doa-doa tersebut dapat mereka panjatkan ketika terkena musibah, Film animasi ini dibuat dengan tujuan agar anak-anak lebih mudah untuk ditanamkan sikap religius yang perlu diambil ketika mengalami musibah. Sehingga, anak-anak tidak berlarut-larut dalam kesedihan, tidak trauma berkepanjangan, dan dapat bangkit kembali untuk menata masa depan. Film animasi ini juga dapat digunakan oleh guru maupun orang tua untuk memberikan pelajaran untuk membangun sikap religius anak agar anak mampu mengatasi musibah. Peserta sosialisasi terdiri dari anak-anak usia 5 sampai 12 tahun atau dinamakan kelas cabe rawit dengan jumlah siswa sekitar 12 orang per kelas serta 2 guru untuk tiap kelas. Kegiatan sosialisasi diadakan di TPQ Nurul Huda Dumai. Setelah kegiatan diharapkan anak-anak dapat melihat unsur edukasi pembelajaran nilai islami yang ditanamkan pada media film animasi 2D vector yang diperlihatkan.Kata kunci: animasi 2D vector, film, motion graphic