bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Mechanisms of HDO-AntimiR by Molecular Dynamics Simulation
Authors: Nishina Kazutaka , Hara Rintaro Iwata , Fukuhara Satoru , Yoshioka Kotaro , Yokota Takanori , Shibuta Yasushi 
Published: November 2021

Abstract
Recently, we found DNA/RNA heteroduplex oligonucleotide-based antimiR (HDO-antimiR) can more efficiently inhibit the target miRNA than conventional antimiR after its cellular uptake. But the mechanism of HDO-antimiR about the target-silencing is unknown. We here tried to elucidate the interaction mechanism of HDO-antimiR to miRNA using molecular dynamics (MD) simulation. When interaction of the conventional antimiR or HDO-antimiR and the target miRNA was simulated, they combined with each other in various forms. In the hydrogen bond analyses, base site of the antimiR formed hydrogen bond with miRNA. On the other hand, phosphate site of the HDO-antimiR formed hydrogen bond with miRNA. These results suggested that there were differences about the binding mechanisms between antimiR and HDO-antimiR to the target miRNA. In particular, there was a difference in the binding site between antimiR and HDO-antimiR. Additionally, it was found that guanine in the miRNA is mainly involved in the binding to the antimiR or HDO-antimiR. MD simulation method is useful in understanding the mechanism of oligonucleotide therapeutics.
UPLC-QTOF-MS-Based Untargeted Study of Metabolites Secreted by Sclerotinia Sclerotiorum Pathogen Under Axenic Condition
Authors: Gupta Navin Chandra , Arora Shaweta , Kundu Aditi , Sharma Pankaj , Rao Mahesh , Bhattacharya Ramcharan 
Published: November 2021

Abstract
The stem rot disease has emerged globally as a major disease threat to the productivity and seed quality of oilseed Brassica. The generalist causal pathogen Sclerotinia sclerotiorum (Lib.) de Bary shows large variability in their aggressiveness and pathogenicity. Revealing the metabolic profile and signaling components of the pathogen in host-pathogen interaction are fundamental in understanding host resistance to the disease. In this study, the metabolites released by the pathogenic strains of S. sclerotiorum under the axenic culture have been identified using the untargeted high-resolution UPLC-QTOF-ESI-MS/MS. The analysis of the ethyl acetate extracts of the S. sclerotiorum culture revealed ten major secondary metabolites namely, sclerin, sclerotinin-B, sclerone, melanin, bostrycoidin, botcinin-D, botcinin-A, gliovirin, scleramide, and botcinic acid. The later six metabolites are being reported for the first time in the culture extract of the S. sclerotiorum pathogen. The phylogenetic analysis based on the overlapping and unique informative peaks in the chromatograms, the six S. sclerotiorum strains were grouped into three major clads. The clustering based on metabolic profiles does not substantiate the diversity based on morphology or virulence differences on the host. The findings of the study signified the metabolites secreted under the axenic conditions are varies based on their growth and developmental stages and may not necessarily be the determining factors for their differential aggressiveness and virulence over the host.
Covalent organic frameworks with high quantum efficiency in photocatalytic hydrogen evolution: mediating charge separation
Authors: Li Chunzhi , Liu Jiali , Li He , Wu Kaifeng , Wang Junhui , Yang Qihua 
Published: November 2021

Abstract
Compared with inorganic semiconductors, the difficulty of exciton dissociation is one of the main reasons for the lower photocatalytic activity of organic semiconductors. In this work, we report that the charge carrier lifetime is dramatically prolonged by incorporating a suitable donor-acceptor (β-ketene-CN) pair to a covalent organic framework nanosheet (CN-CON). CN-CON showed remarkably high apparent quantum efficiency up to 82.6% at 450 nm in photocatalytic H2 evolution, superior to all the COFs reported so far. The charge carrier kinetic analysis and femtosecond transient absorption spectroscopy characterizations verified that CN-CON had intrinsically lower exciton binding energies and hence longer-lived charge carriers than the corresponding CON without CN unit. This work provides an excellent model for gaining insight into the nature of ultrashort-lived active species in polymeric organic photocatalysts.
Diabetic Foot Disease Research in Aotearoa New Zealand: A Bibliometric Analysis (1970-2020)
Authors: Carroll Matthew , Al-Busaidi Ibrahim Saleh , Coppell Kirsten J , Garrett Michele , Ihaka Belinda , O'Shea Claire , Wu Justina , York Steve 
Published: November 2021

Abstract
Aim

The aim of this bibliometric study was to examine trends in the quality and quantity of published diabetic foot disease (DFD) research in Aotearoa/New Zealand (NZ) over the past five decades.
Method

In July 2021, the Scopus® database was searched for DFD-related publications (1970-2020) using predetermined search and inclusion criteria. Bibliometric data were extracted from Scopus® and Journal Citation Reports. Retrieved bibliographic indicators were analysed in Biblioshiny, an R Statistical Software interface and reported using descriptive statistics.
Results

Forty-seven DFD-related articles were identified. The annual number of publications showed a significant upward trend increasing from one in 1988 to 47 in 2020 (P < 0.001). The majority of identified articles (n = 31, 66%) were published in the last decade (2011-2020). Basic/clinical research accounted for 87% (n = 41) of publications and 14 (30%) investigated the screening and/or prevention of DFD. The average citation per article was 20.23 (range: 0-209) and the median impact factor was 4.31 (range, 1.82-79.32). Over a third of articles (36%) had an international authorship network. Funding was reported by 15 (32%) articles; 12 (26%) were supported by public national grants vs. three (6%) reporting industry-sponsorship.
Conclusion

DFD articles authored by NZ researchers have increased over the past five decades. Despite that NZ researchers increased their global impact through collaborative networks, most of the research was classified as low-level evidence, with limited focus on Indigenous Māori and limited financial support and funding. Increased funding for interventional research is required to enable a higher level of evidence-based and practice-changing research to occur. With rates of diabetes related amputations higher in Māori future research must focus on reducing inequalities in diabetes related outcomes for Māori by specifically targeting the prevention and screening of DFD in primary care settings in NZ.
Associations of self-repression with disordered eating and symptoms of other psychopathologies for men and women
Authors: Bachner-Melman Rachel , Watermann Yonatan , Lev-Ari Lilac , Zohar Ada H. 
Published: November 2021

Abstract
Background: Disordered eating has been found to be associated with self-repression, specifically with selflessness, the tendency to relinquish one’s needs for others’, and concern for appropriateness, an alertness to information about social comparison and tendency to vary one’s behavior in different social situations. This study aimed to examine associations between these self-repression variables and symptoms of general psychopathology for women and men in a community sample. Methods: Two hundred and thirty-six participants (92 men) aged 18-76 (M=29.11+10.10) volunteered to complete measures of ED symptoms (EDE-Q), concern for appropriateness (CFA-CSV and CFA-ATSCI), selflessness (SS), and symptoms of depression (PHQ-9), anxiety (BSI-18 anx) and somatization (BSI-18 som) online. Structural equation models were built to assess pathways between the study variables for men and women separately. Results: A MANOVA 2*7 design showed that women scored significantly higher than men on the SS, EDE-Q and PHQ-9. For men, SS scores were positively and significantly associated only with PHQ-9 scores. CAS-CSV scores were positively associated with PHQ-9, BSI-18 som and BSI-18 anx scores. For women, SS scores were positively and significantly associated with PHQ-9, EDE-Q, BSI-18 som and BSI-18 anx scores. CAS-CSV scores were positively and significantly associated with PHQ-9, BSI-18 anx and BSI-18 som scores but not EDE-Q scores. CAS-ASCI scores were positively and significantly associated only with EDE-Q scores.Conclusions: Self-repression is a much more central path to psychopathology in women than in men. For men, self-suppression seems to play an important role in the development and maintenance of symptoms of internalizing disorders, but not disordered eating. Even for women, it appears that self-repression is not connected specifically with disordered eating, but with symptoms of psychopathology in general. Future research should explore why self-suppression plays such a central role in women’s psychopathology.
Soil Respiration Variations in Temperate Rhododendron (Rhododendronarboreum) Forest of Annapurna Conservation Area (ACA) in Nepal
Authors: Dhital Deepa , Manandhar Puruswattam , Gosain Bikash , Sijapati Jaishree 
Published: November 2021

Abstract
Background: Photosynthetic carbon released into the atmosphere in the form of carbon dioxide (CO2) which represented by soil respiration (SR), is considered the largest carbon (C) efflux of terrestrial ecosystem. Understanding the dynamics of SR is critical to coping with prevailing climate change from regional to global scale. Temperate forests are considered as most fragile hence need to recognize their vulnerability owing to continuous climatic changes and anthropogenic activities. Predicting the response of SR is essential, owing to the varying environmental factors that are most dominantly effective to become common determinants of forest carbon variability. This study aimed to assess SR by using closed chamber method in the natural Rhododendron arboretum forest in Annapurna Conservation Area (ACA) which is recognized as the world’s largest forest type located in a temperate region of Nepal. This research additionally aimed to evaluate the consequences of multiple ecological parameters mainly climatic and biotic factors on SR variations in consecutive two years measurement period in October 2016 and 2017.Results: Overall, SR in the forest well corresponded with the soil temperature (ST) variables. Within a short-range (2-3°C) of ST difference the variation in SR was recognized as highly significant (p<0.05) exponential curve (y=1.049e0.529x, 2016 and y = 26.34e0.284x, 2017). However, the effect of soil water content (SWC) on SR was scattered and clear effects of photosynthetic photon flux density (PPFD) were also not detected. Contrary to ST and SWC, seasonal trend of SR was compatible with the PPFD and litter input. The temporal, diurnal, and inter-annual variations of SR, ST, SWC and litter fall were accountable.Conclusions: Temperate forest could store the maximum amount of soil C with limited C emission through SR and become a larger sink of atmospheric CO2. SR is very sensitive to environmental changes and interactively affected by multiple ecological factors, even though it is often difficult to separate their interactions. This founding research is adequate measure in temperate Rhododendron forest; further study seeks understanding on how C emission responds to the regional climate warming, through changing precipitation and landuse, and integrates these feedbacks into global climate models and carbon budget.
Genetic Characterization of Fall Armyworm in Africa Indicates a Limited Capacity for Transcontinental Population Movements and Evidence of a Second Introduction
Authors: Nagoshi Rodney N. , Goergen Georg , Koffi Djima , Agboka Komi , Adjevi Anani Kossi Mawuko , Du Plessis Hannalene , Berg Johnnie Van den , Tepa-Yotto Ghislain T. , Winsou Jeannette K. , Meagher Robert L. , Brévault Thierry 
Published: November 2021

Abstract
The fall armyworm, Spodoptera frugiperda (J.E. Smith) is native to the Americas and a major pest of corn and several other crops of economic importance. The species has characteristics that make it of particular concern as an invasive pest, including broad host range, long-distance migration behavior, and a propensity for field-evolved pesticide resistance. The discovery of fall armyworm in western Africa in 2016 was followed by what was apparently a remarkably rapid spread throughout sub-Saharan Africa by 2018, causing economic damage estimated in the tens of billions USD and threatening the food security of the continent. Understanding the history of the fall armyworm invasion of Africa and the genetic composition of the African populations is critical to assessing the risk posed to different crop types, the development of effective mitigation strategies, and to make Africa less vulnerable to future invasions of migratory moth pests. This paper tested and expanded on previous studies by combining data from 22 sub-Saharan nations during the period from 2016-2019. The results support initial descriptions of the fall armyworm invasion, including the near absence of the strain that prefers rice, millet, and pasture grasses, while providing additional evidence that the magnitude and extent of FAW natural migration on the continent is more limited than expected. The results also show that a second entry of fall armyworm likely occurred in western Africa from a source different than that of the original introduction. These findings indicate that western Africa continues to be at high risk of future introductions of FAW, which could complicate mitigation efforts.
The estimated disease burden of acute COVID-19 in the Netherlands in 2020, in disability-adjusted life-years
Authors: McDonald Scott A. , Lagerweij Giske R. , de Boer Pieter , de Melker Hester E. , Pijnacker Roan , Gras Lapo Mughini , Kretzschmar Mirjam E. , Hartog Gerco den , Gageldonk-Lafeber Arianne B. van ,   RIVM COVID-19 surveillance and epidemiology team, Hof Susan van den , Wallinga Jacco 
Published: November 2021

Abstract

Background. The impact of the COVID-19 pandemic on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or intensive care unit (ICU) admission, results in prolonged and chronic illness, or leads to premature death. Our objectives were to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how disease burden varies between age-groups and occupation categories.Methods. Using standard methods and diverse data sources (registered COVID-19 deaths, hospital and ICU admissions, population-level seroprevalence, mandatory notifications, and the literature) , we estimated the total years of life lost (YLL), years lived with disability (YLD), DALY and DALY per 100,000 population due to COVID-19, excluding its post-acute sequelae, and additionally stratified by 5-year age-group and occupation.Results. The total disease burden in the Netherlands in 2020 due to acute COVID-19 was 273,500 (95% CI: 268,500–278,800) DALY, and the per-capita burden was 1570 (95% CI: 1540–1600) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from the 60-64 years age-group. The per-capita burden by occupation category was highest for healthcare workers and lowest for the catering sector.Conclusions. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. Total DALY were much higher than for other high-burden infectious diseases, but lower than the estimated annual burden from coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected health burden due to COVID-19 among subgroups of the population, and the possible gains from targeted preventative interventions.
A Black Hole-Aided Deep-Helix Channel Model for DNA
Authors: Sarker Md. Abdul Latif , Kader Md. Fazlul , Sarker Md. Mostafa Kamal , Lee Moon Ho , Han Dong Seog 
Published: November 2021

Abstract

In this article, we present a black-hole-aided deep-helix (bh-dh) channel model to enhance information bound and mitigate a multiple-helix directional issue in Deoxyribonucleic acid (DNA) communications. The recent observations of DNA do not match with Shannon bound due to their multiple-helix directional issue. Hence, we propose a bh-dh channel model in this paper. The proposed bh-dh channel model follows a similar fashion of DNA and enriches the earlier DNA observations as well as achieving a composite like information bound. To do successfully the proposed bh-dh channel model, we first define a black-hole-aided Bernoulli-process and then consider a symmetric bh-dh channel model. After that, the geometric and graphical insight shows the resemblance of the proposed bh-dh channel model in DNA and Galaxy layout. In our exploration, the proposed bh-dh symmetric channel geometrically sketches a deep-pair-ellipse when a deep-pair information bit or digit is distributed in the proposed channel. Furthermore, the proposed channel graphically shapes as a beautiful circulant ring. The ring contains a central-hole, which looks like a central-black-hole of a Galaxy. The coordinates of the inner-ellipses denote a deep-double helix, and the coordinates of the outer-ellipses sketch a deep-parallel strand. Finally, the proposed bh-dh symmetric channel significantly outperforms the traditional binary-symmetric channel and is verified by computer simulations in terms of Shannon entropy and capacity bound.
Impact of metabolic indices of 18F-fluorodeoxyglucose positron emission tomography/computed tomography on post transplantation recurrence of hepatocellular carcinoma.
Authors: Bauschke Astrid , Altendorf-Hofmann Annelore , Brückner Lukas , Drescher Robert , Freesmeyer Martin , Settmacher Utz 
Published: November 2021

Abstract
Background
Tumor recurrence is the leading cause of death after liver transplantation in patients with hepatocellular carcinoma. There is an ongoing debate as to whether metabolic indices such as tumor to liver standardized uptake value ratio in 18 F-fluorodeoxyglucose positron emission tomography/computed tomography of the primary tumor can identify patients outside the Milan criteria with as low recurrence rates as patients inside Milan and thus should be added to the established prognostic factors.
Methods
This retrospective study analyzes 103 consecutive patients who underwent 18 F fluorodeoxyglucose positron emission tomography/computed tomography before liver transplantation for hepatocellular carcinoma using data of clinical tumor registry. Primary endpoints were overall survival and 10-year cumulative recurrence rates.
Results
Tumor to liver standardized uptake value ratio of the primary tumor was statistically significant higher in Milan out tumors, “up-to-seven” out tumors, grade 3 tumors, alpha-fetoprotein level >400 ng/ml and lesions upwarts 5cm in diameter. Factors with statistically significant influence on the 10-year overall survival in the univariate analysis were Milan, up-to-seven” criteria, number of lesions and pT-category. COX regression analysis did not show independently statistically significant factors for 10-year overall survival. Milan, “up-to-seven” criteria, grade, pV, number of lesions, size of lesion, pT-category, tumor to liver standardized uptake value ratio influenced 10-year cumulative recurrence rates statistically significantly. Tumor to liver standardized uptake value ratio, grade and pT-category proved to be independently statistically significant factors for 10-year cumulative recurrence rates.
Conclusions
Our study suggests that tumor to liver standardized uptake value standardized uptake value ratio in 18 F-fluorodeoxyglucose positron emission tomography/computed tomography is an independent prognostic factor in transplanted patients with hepatocellular carcinoma and might be helpful in estimating the risk of recurrence for patients scheduled for liver transplantation.
Maximum logq Likelihood Estimation for Parameters of Weibull Distribution and Properties: Monte Carlo Simulation
Authors: Cankaya Mehmet Niyazi , Vila Roberto 
Published: November 2021

Abstract
The maximum logq likelihood estimation method is a generalization of the known maximum log likelihood method to overcome the problem for modeling non-identical observations ( inliers and outliers). The parameter $q$ is a tuning constant to manage the modeling capability. Weibull is a flexible and popular distribution for problems in engineering. In this study, this method is used to estimate the parameters of Weibull distribution when non-identical observations exist. Since the main idea is based on modeling capability of objective function p(x; ʘ) = logq [f(x; ʘ)], we observe that the finiteness of score functions cannot play a role in the robust estimation for inliers . The properties of Weibull distribution are examined. In the numerical experiment, the parameters of Weibull distribution are estimated by logq and its special form, log , likelihood methods if the different designs of contamination into underlying Weibull distribution are applied. The optimization is performed via genetic algorithm. The modeling competence of p(x; ʘ) and insensitiveness to non-identical observations are observed by Monte Carlo simulation. The value of $q$ can be chosen by use of the mean squared error in simulation and the $p$ -value of Kolmogorov - Smirnov test statistic used for evaluation of fitting competence. Thus, we can overcome the problem about determining of the value of $q$ for real data sets.