bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmaceutical Management of General Anxiety Disorder
Authors: Hafiz Rehab , Fairaq Khawlah , Alfawzan Lama , Alharazi Sharaf , Alrsheed Atheer , Alzahrani Abeer , Sultan Faris , Alhuthail Aroob , Bashaikh Hanin , Alsomali Norah , Alwafi Sohaib , Bukhari Mohammed , Aljuhani Turky 
Published: December 2021

Generalized anxiety disorder (GAD) is a mental disorder defined as excessive worrying over little things. It is a one of the most common types of anxiety disorders. A study stated that 1-5% of the general population suffers from GAD. The condition affects the quality of life of a patient negatively and activities in their everyday life. In this review article, we highlighted several studies that compared combined therapy of psychotherapy and pharmacotherapy to either therapy alone, results were conflicting and differ from one study to another. Provide a thorough and comprehensive review of the different approaches of GAD management, several database websites were searched for articles discussing the pharmacological management of general anxiety disorder. Clinical trials, clinical guidelines, systematic reviews, meta-analyses and review articles were all reviewed and considered for inclusion. The review emphasizes the importance of taking the decision of therapy after counseling the patient, taking into account, the cost effectiveness of the treatment, patient’s symptomatology, comorbidity, medical conditions, concomitant using medications, previous trials and preference. Accordingly, thorough assessment should be done before moving to management plan, and a trial of other group or other therapies should be taken if there is no response seen. However, generalized anxiety disorder is one of the most common types of anxiety disorders. It has a lifetime prevalence around 5%, it can include intolerable cognitive, emotional and physical symptoms. Thus, GAD can adversely affect the patient’s life aspects, including personal, functional, social or educational. There are options to be taken among psychotherapy, pharmacotherapy or combined therapy.
Case Report on Chiari Syndrome
Authors: Meshram Asawari , Tembhare Vaishali , Singh Seema , Sharma Ranjana , Ankar Ruchira , Meshram Khushabu , Nakhale Puja , Sakharwade Prerana 
Published: December 2021

Chiari Malformation is a rare condition. A condition known as Chiari malformation occurs when brain tissue spreads into the spinal canal. When a portion of your skull is excessively small or malformed, it presses on your brain and forces it downward. Chiari malformation is a rare occurrence, although the increased use of imaging testing has resulted in more diagnosis.
Case Presentation: A 18-year-old boy was admitted to the hospital with the following symptoms: Tingling sensation, numbness over left hand since 2 to 3 months. Neck bend toward right side, pain in left hand since 6 month. Difficulty during eating by hand since 2 to 3 month. On physical examination, indicated a bright attentive person with pale conjunctiva and no symptoms of icterus. He had a tachycardia, bilateral pitting pedal edema and a swollen abdomen with shifting dullness, all of which pointed to as cites. He had a history of intermittent abdominal pain. On admission he complaint of new onset of dyspnea on exertion, fatigue and abdominal swelling. The rest of all physical examination was normal, with no skin changes and an intact arterial pulses in all four extremities.
Conclusion: The primary focus of this case study is on professional management and outstanding nursing care, which may provide the holistic care that Chiari Syndrome necessitates while also effectively managing the challenging case. After a full recovery, the patient's comprehensive health care team collaborates to help the patient regain his or her previous level of independence and satisfaction.
Multidrug Resistance among Gram Negative E. coli in Chicken Meat (Rafha-Saudi Arabia)
Authors: Ali Akbar , Chidrawar Vijay R. 
Published: December 2021

Aims: Multidrug resistant (MDR) bacteria pose a major public health issuer globally. The genes for antibiotic resistance are transferred vertically in the form of genomic DNA and horizontally in the form of plasmids or transposons. Antibiotic are extensively used in animal farming to treat and prevent animal diseases, and at sub-therapeutic doses, they are used to promote animal growth. This extensive use of antibiotics is causing an increase in resistance among bacteria. More frequent, chicken meat available at retail shops is reported to be contaminated with a variety of drug resistant bacteria including E. Coli. The aim of the present study was to investigate antibiotic resistance in Escherichia coli strains isolated from chicken meat available in the local shops of Rafha, Saudi Arabia.
Place and Duration of Study: Department of basic health sciences, College of Pharmacy, Northern Border University, Rafha, Saudi Arabia, between February and October, 2019
Methodology: Eighty-six E. coli strains, isolated from chicken meat, were tested for their antibiotic resistance profile, using the disc diffusion method.
Results: All the isolated E. coli strains were tested against 14 antibiotics. The maximum resistance was found against penicillin G (95%) followed by amoxicillin (85%), Cephalothin (81%), Erythromycin (72%), and Tetracycline (50%). Imipenem was the most effective agent of all with only 1% resistance followed by Cefepime with almost 6% resistance.
A high percentage of the isolates (57%,) were multidrug resistant as they were non—susceptible to at least one antimicrobial in ≥3 antimicrobial classes including amoxicillin, erythromycin and tetracycline.
Conclusion: The prevalence of MDR E. coli in retail chicken meat is very high and could pose a serious threat to public health.
Correlation of HBA1c and Serum Cholesterol in Diabetic Patients
Authors: Laghari Mubeena , Adnan Faryal , Tehzeen Aneela , Talpur Zuha , Ahmed Arsalan , Murtaza Shazia 
Published: December 2021

Aim: To determine the correlation of HBA1c and serum cholesterol in diabetic patients.
Methodology: This case control study was completed at the Biochemistry and Medicine Departments of Liaquat University Hospital Jamshoro from October 2015 to March 2016.Total number of study subject was 100 and they were divided into two groups. Group A (case group, n=50) comprises diagnosed T2DM subjects while group B (control group, n=50) consists of healthy normal subjects (HNS), healthy normal subjects with mean age 50±6.34 years. These subjects were assessed to find association of glycosylated hemoglobin with serum Cholesterol levels in Type-2 Diabetes mellitus patients. Those patients diagnosed asT2DM with age 30- 60years were included while those patients diagnosed as diabetic erectile dysfunction, diabetic nephropathy, diabetic renal failure, familial dyslipidemia, and hypercholesterolemia was excluded in this study. Blood specimens were collected from both groups aseptically then blood glucose, HbA1c, Blood cholesterol, were estimated. Written consent was taken by all subjects including in this study. Data was analyzed by SPSS version 21.0. P value ≤ 0.05 were considered significant. Results: The mean fasting blood sugar (FBS) of study participants of both groups was 162.74±25.42 mg/dL and 82.60±10.03 mg/dL respectively. The mean random blood sugar of both groups was 299.72±57.88 mg/dL and142.72±31.63 mg/dL respectively and mean glycosylated hemoglobin (HbA1C) of both groups was 8.40±1.27 and 5.75±0.24mg/dL respectively. The mean serum cholesterol values of DP and HNS were 7.05±1.02 and 5.74±1.45 mg/dl respectively. Conclusion: It was observed a positive correlation between HBA1c and serum cholesterol in type2 DM patients.
Case Report of Typhoid Fever (Salmonella typhi)
Authors: Dhengare Archana , Pohekar Savita , Sakharwade Prerana , Sakharkar Sheetal , Gujhar Samrudhi , Tembare Vaishali , Ankar Ruchirra 
Published: December 2021

Typhoid fever is a major health problem globally. Typhoid fever is an enteric fever characterized by systemic illness along with abdominal pain and fever in a "step-ladder" pattern. Typhoid fever is one of the major causes of mortality and morbidity in overcrowded and unhygienic areas though comprehensive research and public health interventions have decreased the occurrence. Patient is having sign symptoms as gastrointestinal symptoms, malaise, hepatomegaly, and high liver enzymes presented with a two-week fever. As a differential diagnosis, a Widal test is done and two blood cultures were requested; both came out positive, confirming the diagnosis of typhoid fever caused by Salmonella typhi. Treatment with ceftriaxone and metronidazole was stared prior to confirmation of the diagnosis, with a partial response; later, pharmacological therapy was altered based on ciprofloxacin susceptibility testing, with a satisfactory clinical response. We look at how to diagnose and treat enteric fever, with an importance to typhoid fever.
Symptoms or important clinical finding:- A 6 year old male was admitted in A.V.B.R.H on date 12/03/2021 with chief complaint of abdominal discomfort, malaise, problems such as fever since 2 weeks, gastrointestinal symptoms, lethargy, hepatomegaly, and an increased liver enzyme.
Diagnosis therapeutic intervention and outcome: A case is diagnosed as Typhoid Fever. After physical examination and investigation, doctor was detected a case of 6 week.
Therapeutic intervention and outcome: Also provide a calcium supplements and iron supplements present case was stable but according to ultrasonography finding. Outcome- Good sanitation, improved water supply, and a suitable sewage waste matter system, as well as the successful use of existing typhoid vaccinations, can all help to avoid typhoid fever.
Nursing Perspective: Administration fluid replacement .i.e DNS and RL monitored vital signs per hourly. Maintained temperature chart 2 hourly strictly, maintained intake output chart properly. Tablet paracetamol, antibiotics given as per doctor’s order.
Conclusion: Good sanitation, improved water supply, and a suitable sewage waste matter system, as well as the successful use of existing typhoid vaccinations, can all help to avoid typhoid fever.
A Computational Approach on the Anti-biofilm Effect of Ocimum sanctum Bio-compounds Against ptk of Acinetobacter baumannii
Authors: Kamalli M. , Girija A. S. Smiline , Ganesh P. Sankar , Priyadharsini J. Vijayashree 
Published: December 2021

Introduction: Acinetobacter baumannii is a gram negative coccobacilli often considered as a nosocomial pathogen and as an opportunistic pathogen in immunocompromised patients. It is considered to be multi-drug resistant and a potent bacteria forming vital biofilms. Ptk which is protein tyrosine kinase is a protein coding gene involved with the synthesis of capsular polysaccharide. Ocimum sanctum is a perennial plant belonging to the Lamiaceae family. Tulsi and holy basil are the common names of this plant. In-silico docking approach method is much more convenient and cost effective to assess the bioactive properties of the natural drugs against any target ligands.
Aim: The aim of the study to assess the inhibitory effect of Ocimum sanctum bio-compounds against ptk of Acinetobacter baumannii using a computational approach.
Materials and Methods: Retrieval of the structure of ptk was followed by Ligand preparation and optimisation. Further drug likeliness was assessed using Molinspiration parameters, docking simulations and visualisation for the binding energy and hydrogen bonds.
Results: Among the bio compounds of O.sanctum, benzofuran is selected as an active inhibitory compound with -11.12 as its binding energy showing a high affinity.
Conclusion: The findings of the present study documents benzofuran as the promising candidate to design novel drugs from O.sanctum and to target the ptk of A.baumannii. However further experimental validation must be done to observe its efficacy and safety in the treatment of nosocomial infections caused by A.baumannii.
Screening and in Silico Validation of Anti-Microbial Peptides Derived from Lysostaphin, Entero and Endolysin
Authors: A. S Kirthick Kumaran , Priyadharsini J. Vijayashree , Girija A. S. Smiline , Ganesh P. Sankar 
Published: December 2021

Introduction: Antimicrobial peptides (AMPs) are small molecules which are known to exert destructive effects upon pathogenic microorganisms. AMPs are designed from proteins obtained from various sources and tested under in vitro conditions to deduce their antimicrobial activity.
Materials and Methods: A few of the peptidoglycan hydrolases such as lysostaphin (AAB53783.1), enterolysin (AGG79281.1), and endolysin (YP_009901016.1) were selected for the study based on an extensive text mining process. The protein sequences of the proteins were retrieved from the NCBI (National Centre for Biotechnology Information) database in the FASTA format (https://www.ncbi.nlm.nih.gov/protein/).
Results and Discussion :In the antimicrobial protein lysostaphin, three antimicrobial peptide are been found, in which two is active and other is inactive, and one has antifungal property with a score of -0.15, and one having cell penetrating property, in which all are non toxic.
Conclusion: The present study predicts AMPs from lysostaphin, entero and endolysins. These peptides were found to possess antifungal, anti-biofilm properties. Most of the peptides predicted were found to be non-cell penetrating and non-toxic.
Respiratory Responses to Short Term Sustained Isometric Muscle Contraction among Undergraduates
Authors: Safiya S. Nehal , Sridevi G. , Preetha S. 
Published: December 2021

Aim: This study sets out to investigate whether a short-term isometric abdominal exercise can benefit adults with improvement in ventilatory functions.
Materials And Methods: The present study was performed in 20 adults from the student population of I-BDS students with no history of smoking and respiratory illness. The participants did a daily 20-minute static abdominal exercise over a period of three days. The lung function test was assessed using spirometry and the values of FVC, FEV1, FEV1/FVC, PEFR, FEF 25-75. Paired dependent t test was done to evaluate the anthropometric variables and changes in lung functions pre-exercise on day 1 and post-isometric exercise on day 3.
Results: The study demonstrated a significant increase in the mean values of forced vital capacity and forced expiratory volume in one second. The FEV1/FVC ratio, PEFR, FEF 25-75% did not reveal significant changes.
Conclusion: The study concluded an innovative finding that ventilatory functions improved after short term isometric training.
A Case Report of Steven Johnson Syndrome
Authors: Dhengare Archana , Sharma Ranjana , Waware Sonali , Wagh Pranali 
Published: December 2021

Introduction: In 1922, two doctors, Albert Mason Stevens and Frank Johnson, examined purulent conjunctivitis.”
Background: Stevens-Johnson syndrome was named after them as a result of their study. The incidence rate is 7 cases per million populations per year.
Case Presentation: Master Yash Ghudam was brought to AVBRH by his parents with chief complaints of fever since 5 days and erythematous lesions all over body since 3 days.
History of present illness: Patient was apparently alright 5 days back, and then he started having fever which was of high grade and was not associated with chills and rigor. Patient was treated on OPD basis and the symptoms of an unexplained disease in two young boys, aged 7 and 8, who had "an unusual, generalised eruption of continued fever, inflamed buccal mucosa, and extreme some antibiotic was given, but there was no relief, after 2 days there was ulcers formation inside the mouth for which some ointment and syrup becosule was started. But lesions were increasing. 3 days back the lesions first appeared on chest then got spread to legs and hands. For which patient was admitted in Chandrapur hospital from were the patient was referred to AVBRH for further management.
Interventions: The patient was treated the patient was started on intravenous and orally Cortecosteroids, Omnacortil 10mg, Antibiotics- Inj. Ceftriaxone1gm IV 12 hourly [100mg/kg/day], inj. Amikacin 150mg IV 12 hourly [15mg/kg/day], Syp. Mucaine gel 2tsp BD – swish and swallow), Syp. Cital 2.5ml TDS, Tab. Chymoral Forte TDS, Inj. Pantop 20mg IV 24 hourly (1mg/kg/dose).
Pandya’s Formula: Syp. Gelusil 5ml, Syp. Benadryl 5ml, Syp. Omnacortil 5ml. Skin allograft: It has been planned.
Conclusion: In this study, we mainly focus on medical management and outstanding nursing care helped prevent farther complication. Overall, the patient's reaction was positive, though recovery time from Steven johnson syndrome varies from person to person, taking weeks, months, or even years. However, only a small number of people completely recover, while some have long-term consequences. She took a long time to get back on her feet.
Evaluation of Various Stress Management Strategies among Chennai People - A Cross Sectional Study
Authors: Mitthun A. N. K. , Sridevi G. , Preetha S. 
Published: December 2021

Background: Feeling stressed is a part of everyone's life. A feeling of emotional or physical tension is known as stress. Relaxation strategies play an important role in overcoming stress.
Objective: To evaluate the different stress patterns, their perceived stress and effects of different stress management strategies.
Methods: A cross sectional study was conducted through a convenience sampling method. The participants were administered with a self developed questionnaire consisting of 11 questions. The responses were collected using google forms. Descriptive statistics, frequency analysis and chi square test was used to analyse the data.
Results: The present study reported that the majority of respondents were stressed due to academic and personal reasons and among the various stress relaxation methods, respondents felt that music and yoga relieved them from stress.
Conclusion: The study concluded an innovative finding that music and yogic exercises when adopted provided a decent stress management strategy that suits the respondents.
Knowledge and Awareness about Postpartum Distress among the Students of Saveetha Dental College
Authors: Daniel Jessly , Priya A. Jothi , Devi R. Gayatri 
Published: December 2021

Introduction: Postpartum depression (PPD) is the most common psychiatric condition after childbirth.
PD has adverse long-term consequences for the mother, the infant’s development and the family environment symptoms-the core symptom of sadness or low mood, as well as fatigue/sleep disturbance and irritability. The aim of the study is to determine the Knowledge and awareness about postpartum distress among the students of saveetha dental college.
Materials & Methods: A cross-sectional survey was conducted among the study population with a sample size of 100. A self administered structured questionnaire was prepared and consisted of 15 questions. It was circulated to participants through an online platform (google form). The statistics were done using SPSS software, chi-square test was used to check the association and P value of 0.05 was said to be statistically significant.The pros of the survey is that the students of different lifestyles and cultures were surveyed . Children and adults were excluded from the survey. Simple random sampling method was the sampling method used to minimise the sampling bias.
Results: Women during postpartum go through a lot of hormonal changes which lead to mood swings etc.They become very self conscious about their body .Mothers can also be depressed due to financial trouble, lactation etc. Chi square test: p-value=2.98> 0.05 hence significant.
Conclusion: In summary, this study demonstrated an honest level of data and positive attitudes towards women with postpartum depression. However, negative beliefs, stigma, and misconceptions still prevailed among the relations.
Pasargadae
Authors: Mohammadkhani Kourosh 
Published: December 2021

Abstract

Monumental building at Pasargadae in Fars in southwestern Iran began under Cyrus the Great around 550
bce
. Located on the Morghab Plain and surrounded by mountains, the monuments of Pasargadae are in a large park referred to as Paradise. Spread over an area of about 300 hectares is a series of monuments. These include structures such as Palace P, sometimes referred to as the Private Palace of Cyrus, Palace S (“Audience Palace”), and Gate R, as well as a royal garden, the tower of Zendan, the citadel of Tol‐e Takht, the sacred precinct, and the monumental Tomb of Cyrus. Even as Persepolis became the new capital of Persia under Darius I, celebrations regularly occurred in memory of Cyrus at Pasargadae, according to evidence from the Persepolis Fortification Tablets.
Persepolis
Authors: Mohammadkhani Kourosh 
Published: December 2021

Abstract

Persepolis, one of the capitals of the Achaemenid Persian Empire, was built during the reign of Darius I. A complex of buildings on and around a terrace with a substantial subterranean canalization system, the site was probably used mainly during Nowruz celebrations in the spring. During other seasons of the year, the Persian kings would use their palatial complexes in Susa, Babylon, and Ecbatana. Persepolis was built between 518 and 330
bce
on a slope of Mount Rahmat. The location benefited from the natural resources of the nearby Polvar River and the fertile Marvdasht Plain. The limestone for the buildings came from quarries in the Marvdasht Plain.
Indika
of Megasthenes
Authors: Ghosh Suchandra 
Published: December 2021

Abstract

Indika
was written by Megasthenes, the Seleucid envoy to the Mauryan capital of Pāṭaliputra during Chandragupta Maurya's reign (fourth century
bce
). The original work did not survive but certain parts are quoted in other works, including those of Diodorus Siculus, Strabo, Arrian, and Pliny, and others are available in fragments. There are many factual inaccuracies, with fantastic descriptions of one‐horned horses with heads like those of deer and huge snakes. Nevertheless, it is an important Greek textual source for understanding Mauryan India.
Li Si
Authors: Sou Daniel Sungbin 
Published: December 2021

Abstract
Li Si is one of the most important historical figures in the Qin, and who supported the First Emperor of Qin in the process of unification. He also played a key role in arguing the benefits of the commandery‐county system that also strengthened the emperor's authority. His life fell into turmoil after he joined Zhao Gao's plot to make Prince Huhai the next emperor, which eventually led to his execution.