bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of changes in heart rate variability indices in driving school cadets with different levels of preparedness
Authors: Bebinov S.E. , Krivoshchekova O.N. , Nechaev A.V. 
Published: December 2021

The research was carried out on two independent experimental groups of boys and girls. The first was observed in traffic conditions, the second during the period of auto-simulator training. The HRV indices were determined: HR - heart rate, IN - index of tension of regulatory systems, AMo - amplitude of the mode, LF/HF - index of vagosympathetic interaction. A pronounced sympathetic reaction of more prepared cadets to the training load with the subsequent restoration of the studied characteristics was revealed.
Key words: heart rate variability, autonomic regulation, vagosympathetic interaction, driver training, level of preparedness.
Normobaric interval hypoxytherapy in the correction of neuroimmunoendocrine disorders in children and adolescents with autoimmune thyroiditis
Authors: Abazova Z.Kh. , Ivanov A.B. , Borukaeva I.Kh. , Shkhagumov K.Yu. 
Published: December 2021

130 children and adolescents aged 6 to 16 years with a diagnosis of autoimmune thy-roiditis (AIT) at the stage of hypothyroidism underwent a course of hypoxytherapy. The high ef-ficiency of the normobaric interval hypoxic training method in the treatment of hypothyroidism on the background of AIT is shown. An increase in the function and number of CD8+ cells after a course of hypoxytherapy prevents the progression of the autoimmune process and promotes the restoration of thyroid function, which in turn leads to positive dynamics in the neurological status of patients: improved indicators of mental performance and fine coordination of move-ments.
Key words: autoimmune thyroiditis, hypothyroidism, hypoxytherapy, interval hypoxic training, neuroimmunoendocrine disorders.
Analysis of energy expenditure of skiers across the preparatory phase
Authors: Bushmanova Е.А. 
Published: December 2021

Energy expenditure was calculated at rest and during physical activity by indirect calorimetry using the Oxyson Pro system in 55 highly elite skiers. The results showed that in 75% of athletes, the measured rest energy expenditure were higher than the calculated rest energy expenditure by 20% and was 2139±363 kcal/day. Daily energy expenditure was 5347±907 kcal. In the structure of rest energy expenditure the part of carbohydrates was 67 % and fats was 33%. Generally, energy expenditure was more 5000 kcal. In addition, in our study, it was observed a progressive increase of contribution of carbohydrate oxidation in energy expenditure during high-intensity exercise.
Key words: energy expenditure, high-intensity exercise, carbohydrates, fats, skiers, indirect calorimetry.
A Nascent Tidal Dwarf Galaxy Forming within the Northern H i Streamer of M82
Authors: Pasha Imad , Lokhorst Deborah , van Dokkum Pieter G. , Chen Seery , Abraham Roberto , Greco Johnny , Danieli Shany , Miller Tim , Lippitt Erin , Polzin Ava , Shen Zili , Keim Michael A. , Liu 刘 Qing 青 , Merritt Allison , Zhang Jielai 
Published: December 2021

Abstract
We identify a ∼600 pc wide region of active star formation located within a tidal streamer of M82 via Hα emission (F
Hα
∼ 6.5 × 10−14 erg s−1 cm−2), using a pathfinder instrument based on the Dragonfly Telephoto Array. The object is kinematically decoupled from the disk of M82 as confirmed via Keck/LRIS spectroscopy and is spatially and kinematically coincident with an overdensity of H i and molecular hydrogen within the “northern H i streamer” induced by the passage of M81 several hundred Myr ago. From H i data, we estimate that ∼5 × 107
M
⊙ of gas is present in the specific overdensity coincident with the Hα source. The object’s derived metallicity (12+

log
(
O

/

H
)
≃
8.6

), position within a gas-rich tidal feature, and morphology (600 pc diameter with multiple star-forming clumps), indicate that it is likely a tidal dwarf galaxy in the earliest stages of formation.
Chemically Fresh Gas Inflows Detected in a Nearby High-mass Star-forming Region
Authors: Chen Xi , Ren Zhi-Yuan , Li Da-Lei , Liu Tie , Wang Ke , Shen Zhi-Qiang , Ellingsen Simon P. , Sobolev Andrej M. , Mei Ying , Li Jing-Jing , Wu Yue-Fang , Kim Kee-Tae 
Published: December 2021

Abstract
We report the detection of a chemically fresh inflow that is feeding high-mass young-stellar-object (HMYSO) growth in the nearby high-mass star-forming region G352.63 made with both the Atacama Large Millimeter/submillimeter Array (ALMA) and the Submillimeter Array (SMA). High-quality images of the dust and molecular lines from both ALMA and SMA have consistently revealed a gravitationally controlled cold (∼10 K) gas inflow of chemically fresh molecules (e.g., CCH and HC3N) toward the central HMYSO and its surrounding dense gas structure, which has a possible torus- or disk-like morphology. The HMYSO is also observed to have an outflow, which is nearly perpendicular to the torus and its parental filament, and thus can be clearly separated from the inflows. These kinematic features provide observational evidence to support the conjecture that the infalling streamers in high-mass star-forming regions could proceed in a similar process to that observed in low-mass counterparts. The chemically fresh infalling streamers could also be involved in the disk or torus configuration, fragmentation, and accretion bursts that occur in both simulations and observations.
Aflibercept for Retinopathy of Prematurity: A Systematic Review and Meta-Analysis
Authors: Chen Po-Yu (Jay) , Rossin Elizabeth J. , Vavvas Demetrios G. 
Published: December 2021

BACKGROUND AND OBJECTIVE:
To determine the effectiveness of aflibercept in retinopathy of prematurity (ROP).

PATIENTS AND METHODS:
We performed a systematic review and meta-analysis of proportions from the literature in PubMed and Cochrane Library using search terms related to the use of aflibercept in ROP. Studies in non-preterm infants or that did not use aflibercept as the initial treatment were excluded. Risk of bias was assessed by the ROBINS-I (Risk Of Bias in Non-randomized Studies of Interventions) tool.

RESULTS:
We identified six case series. Collectively, 218 eyes were treated with aflibercept for ROP. We found an average 97% (95% confidence interval [CI], 93% to 99%) regression rate with aflibercept and an average 16% (95% CI, 5% to 41%) recurrence rate. With the exception of one outlier study, these numbers are similar to previous reports using anti–vascular endothelial growth factor (VEGF) agents in ROP.

CONCLUSIONS:
Aflibercept holds promise for use in ROP and has been demonstrated to be efficacious in six case series. Randomized, controlled clinical trials appear warranted to compare aflibercept with other anti-VEGF agents.

[
Ophthalmic Surg Lasers Imaging.
2021;52:673–681.]
À la recherche du quaestor Ostiensis
Authors: Berrendonner Clara 
Published: December 2021

La catégorie mommsénienne des « quaestores classici » n’étant selon toute vraisemblance pas valide, le quaestor Ostiensis n’a pas à y être rattaché. L’article dresse la prosopographie des questeurs d’Ostie et tente de cerner leurs attributions. La prouincia Ostiensis était probablement un poste non permanent de la questure urbaine, chargé du ravitaillement de Rome pendant les années de crise frumentaire.
Il molo est-ovest a Portus
Authors: Meléndez Javier Bermejo , Carrasco Juan M. Campos , Meléndez Alberto Bermejo , D’Ammassa Cristian , Sutilo Lucía Fernández , Vázquez Francisco Marfil , Sebastiani Renato 
Published: December 2021

Nel quadro del protocollo d’intesa siglato tra il Parco Archeologico di Ostia Antica e l’Università di Huelva, è stato avviato un progetto di ricerca su uno dei moli interni est-ovest di Portus, quello detto «Molo della Lanterna». Si espongono i risultati della prima campagna di studi, in particolare, l’analisi della struttura del molo in un’area della testata, che permettono di avere una conoscenza preliminare di un aspetto molto significativo del principale sistema portuale dell’impero. I dati finora ottenuti riguardano principalmente il sistema di costruzione della testata del molo, le ultime fasi di utilizzo delle strutture ad essa annesse, riconducibili ad un periodo successivo al V sec. d. C., nonché informazioni relative al paleoambiente circostante.
Introduction
Authors: Lamoine Laurent 
Published: December 2021

Dès 1965 et jusqu’à son décès en 2017, M. Cébeillac-Gervasoni a œuvré pour la connaissance du corpus épigraphique d’Ostie et il est apparu intéressant d’analyser le rôle des études ostiennes dans l’élaboration des programmes de recherche qu’elle dirigea des années 1980 à sa retraite du CNRS. Les années 1970-1980, dans le cadre de son enquête doctorale sur les magistrats des cités du Latium et de la Campanie et de ses nombreuses activités et responsabilités en Italie, voient se développer avec Ostie comme un laboratoire des questionnements et des premiers résultats sur le monde municipal italien antique. Avec la naissance du programme EMIRE dans les années 1990, M. Cébeillac-Gervasoni profite de cette expérience pour infléchir les recherches en direction de l’histoire socio-économique puis vers l’étude des rapports institutionnels entre les cités locales entre elles et avec Rome. C’est d’ailleurs à partir de cette base institutionnelle qu’EMIRE se métamorphose en « Quotidien municipal » en 2002. Indépendamment de ce programme, M. Cébeillac-Gervasoni est sollicitée pour rédiger avec F. Zevi et M.L. Caldelli un manuel d’épigraphie latine fondé sur le corpus ostien en 2006. Lors de sa dernière décennie 2010-2017, elle revient à ses amours de jeunesse : avec F. Zevi, elle initie les séminaires ostiens de 2012, 2013 et 2015, dont profite la réalisation d’un corpus de plus de 2 000 inscriptions funéraires inédites d’Ostie, publié en 2018.
Sortir de l’histoire
Authors: Gally Michèle 
Published: December 2021

Il s’agit d’interroger les liens que la littérature narrative des XXe et XXIe siècles tisse avec le « Moyen Âge » ou, plus exactement, avec l’« idée de Moyen Âge ». Nous proposons, en effet, de voir, dans quelques récits qui situent leurs intrigues à différents moments de ces siècles dits médiévaux (de Druon à Graciano en passant par Michon ou Minard…), moins la reconduction et la recréation d’une époque historique précise que le désir de plonger les lecteurs dans un passé qui, tel que réécrit, n’exista jamais. Si ce mouvement de dés-historicité est particulièrement évident dans des genres grand public comme la Fantasy, il se retrouve aussi dans des textes moins normés, à l’écriture singulière. Ces œuvres mettent ainsi en crise le modèle fondateur du roman historique par ce que j’appelle une sortie de l’histoire.
Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing
Authors: Wang Xuefei , Shen Xiangru , Chen Shan , Liu Hongyi , Hong Ni , Zhong Hanbing , Chen Xi , Jin Wenfei 
Published: December 2021

Abstract
Classic T cell subsets are defined by a small set of cell surface markers, while single-cell RNA sequencing (scRNA-seq) clusters cells using genome-wide gene expression profiles. The relationship between scRNA-seq clustered populations (scCPops) and cell surface marker–defined classic T cell subsets remains unclear. In this article, we integrated six bead-enriched T cell subsets with 62,235 single-cell transcriptomes from human PBMCs and clustered them into nine scCPops. Bead-enriched CD4+/CD45RA+/CD25− naive T and CD8+/CD45RA+ naive T cells were mainly clustered into their scCPop counterparts, while cells from the other T cell subsets were assigned to multiple scCPops, including mucosal-associated invariant T cells and NKT cells. The multiple T cell subsets forming one scCPop exhibit similar expression patterns, but not vice versa, indicating scCPop is a more homogeneous cell population with similar cell states. Interestingly, we discovered and named IFN signaling–associated gene (ISAG) high T (ISAGhi T) cells, a T cell subpopulation that highly expressed ISAGs. We further enriched ISAGhi T cells from human PBMCs by FACS of BST2 for scRNA-seq analyses. The ISAGhi T cell cluster disappeared on t-distributed stochastic neighbor embedding plot after removing ISAGs, whereas the ISAGhi T cell cluster showed up by analysis of ISAGs alone, indicating ISAGs are the major contributor of the ISAGhi T cell cluster. BST2+ and BST2− T cells showing different efficiencies of T cell activation indicate that a high level of ISAGs may contribute to quick immune responses.
Serum 8-Hydroxydeoxyguanosine Is a Potential Indicator for the Severity and Prognosis in Patients with Community-Acquired Pneumonia: A Prospective Cohort Study
Authors: Cao Lin-Feng , Cheng Jia-Yi , Xu Zheng , Feng Chun-Mei , Zhao Hui , Wang Xin-Ming , Fu Lin 
Published: December 2021

Abstract
Previous studies have demonstrated that 8-hydroxydeoxyguanosine (8-OHdG) exerted key roles in various pulmonary diseases, but the evidence for its role in community-acquired pneumonia (CAP) was lacking. The goal of this research was to evaluate the correlations of serum 8-OHdG with the severity and prognosis among patients with CAP through a prospective cohort study. A total of 239 patients with CAP and 239 healthy participants were enrolled. Fasting blood samples were collected. 8-OHdG and inflammatory cytokines were measured by ELISA. On admission, serum 8-OHdG was significantly increased in patients with CAP compared with control subjects. Besides, serum 8-OHdG was incrementally increased in line with CAP severity scores. Pearson correlative analysis found that serum 8-OHdG was correlated with clinical characteristics and inflammatory cytokines in patients with CAP. Linear and logistic regression analysis showed that serum 8-OHdG was positively associated with CAP severity scores. Furthermore, the prognostic outcomes were tracked. Higher serum 8-OHdG on admission increased the risks for intensive care unit admission, mechanical ventilation, vasoactive agent usage, death, and longer hospital stay among patients with CAP. Serum 8-OHdG combination with confusion, respiratory rate, blood pressure, and age ≥65 y or pneumonia severity index had stronger predictive powers for death than single 8-OHdG, CAP severity scores, or several inflammatory cytokines in patients with CAP. These results indicated that serum 8-OHdG is positively associated with the severity and poor prognosis in patients with CAP, demonstrating that 8-OHdG may be involved in the pathophysiology process of CAP.
Opbakning til forfejlede forsørgere!
Authors: Nørgård Inger Lyngdrup 
Published: December 2021

The purpose of this article is to examine a remarkable change – not yet explored from a gender perspective – which occurred during the Three Year War (1848–51) as both the social legislation and philanthropic associations started to seek to help male providers. The purpose of this shift was to ensure that these men could fulfill their role as responsible providers for themselves and their family. This new distribution strategy continued in the time to come in the philanthropic associations and the temporary social legislation introduced in Denmark in the 1950s.
This strategy seeking to support the male, poor and responsible bread­winners represented a significant change, as the strategy until the middle of the 19th century entailed an intention to support women, children, the sick and the elderly. In order to explore this change, this article presents an analysis including central categories in social history. These categories are “need,” “worthiness” and “the breadwinner role,” which are examined from a gender perspective. The analysis suggests that the introduction of the “respectable male bread­winner position” as a new target group in the field of public care accelerated the development of poor relief into social policies.
The material used in the study consists of published legislation, annual reports, literature from the public relief as well as from private philanthropic associations. Furthermore, archival material consisting of handwritten letters, meeting summaries, reports and negotiation protocols are also included.
Penerapan Senam Ergonomik Pada 2 Klien Yang Mengalami Nyeri Musculoskeletal Disorders
Authors: Kirnandri Dwi Rizkia , Rejeki Herni 
Published: December 2021

AbstractOne of the diseases due to work fatigue caused by non-ergonomic conditions is the occurrence musculoskeletal disorders. It is disorder of skeletal mucles with cause damage to joints, ligaments, and tendons caused by muscles receiving repetitive and continuous staticloads for a long period of time. This study aims to apply ergonomic gymnastic in reducing pain caused by this disorder. It focused on two families with musculoskeletal disorders. The result stated before applying the intervention, both patients feels pain in scale 6. It reduced into scale 1 after applying the intervention. Thus, it cold be concluded this gymnastics can reduced pain of musculoskeletal disorders on the sufferers. Therefore, it is expected to the patients for controlling the pain by practicing an ergonomic stretching independently.Keywords: ergonomic gymnastics, musculoskeletal disorders, pain
AbstrakSalah satu penyakit akibat kerja yang disebabkan oleh keadaan tidak ergonomik adalah musculoskeletal disorders. Musculoskeletal disorders merupakan keadaan dengan gangguan pada otot skeletal yang menyebabkan kerusakan pada sendi, ligamen, dan tendon diakibatkan karena otot menerima beban statis secara repetitive dan terus menerus dalam jangka waktu lama. Tujuan karya tulis ilmiah ini untuk menerapkan senam ergonomik untuk menurunkan nyeri musculoskeletal disorders. Fokus studi kasus pada karya tulis ilmiah ini adalah 2 keluarga yang mengalami nyeri musculoskeletal disorders. Hasil menunjukan sebelum intervensi, pasien 1 dan 2 mengeluh nyeri dengan skala 6. Setelah dilakukan intervensi, pada pasien 1 dan 2 menunjukan penurunan skala nyeri dari skala 6 menjadi skala 1. Kesimpulannya senam ergonomik dapat menurunkan nyeri musculoskeletal disorders pada pekerja yang mengalami nyeri muculoskeletal. Saran bagi pasiendiharapkan mampu mengontrol nyeri dengan cara latihan peregangan senam ergonomic secara mandiri. Kata kunci: Senam Ergonomik, Musculoskeletal Disorders, Nyeri
Summer variability of the atmospheric NO2:NO ratio at Dome C, on the East Antarctic Plateau
Authors: Barbero Albane , Savarino Joël , Grilli Roberto , Frey Markus M. , Blouzon Camille , Helmig Detlev , Caillon Nicolas 
Published: December 2021

Abstract. Previous Antarctic summer campaigns have shown unexpectedly high levels of oxidants in the lower atmosphere of the continental plateau as well as at coastal regions, with atmospheric hydroxyl radical (OH) concentrations up to 4 × 106 cm−3. Such high reactivity of the summer Antarctic boundary layer results in part from the emissions of nitrogen oxides (NOx ≡ NO + NO2) produced during photo-denitrification of the snowpack, but its underlying mechanisms are not yet fully understood as some of the chemical species involved (NO2, in particular) have not yet been measured directly and accurately. To overcome this crucial lack of information, newly developed optical instruments based on absorption spectroscopy (incoherent broadband cavity enhanced absorption spectroscopy or IBBCEAS) were deployed for the first time at Dome C (−75.10 lat., 123.33 long., 3,233 m a.s.l) during the 2019–2020 summer campaign to refine uncertainties in snow-air-radiation interaction. These instruments directly measure NO2 with a detection limit of 30 pptv (parts per trillion by volume or 10–12 mol mol−1) (3σ). We performed two sets of measurements in December 2019 (4th to 9th) and January 2020 (16th to 25th) to capture the early and late photolytic season, respectively. Late in the season, the daily averaged NO2 : NO ratio (0.4 ± 0.4) matches that expected for photochemical equilibrium through Leighton’s extended relationship involving ROx (0.6 ± 0.3). In December, however, we observe a daily averaged NO2 : NO ratio of 1.3 ± 1.1, which is approximately twice the daily ratio of 0.7 ± 0.4 calculated for Leighton equilibrium. This suggests that more NO2 is produced from the snowpack early in the photolytic season (December 4th to 9th) possibly due to stronger UV irradiance caused by a smaller solar zenith angle near the solstice. Such a high sensitivity of the NO2 : NO ratio to the sun’s position is of importance for consideration in atmospheric chemistry models.
COVID-19 Anxiety and Associated Factors among Finalist Undergraduate Science Teachers
Authors: Rukundo Aloysius , Santson David Ayebare 
Published: December 2021

The advent of the COVID-19 pandemic inflicted excruciating psychological problems and elevated social concerns globally, including anxiety among university students. This study assessed the prevalence and factors associated with COVID-19 anxiety among finalist undergraduate students pursuing a degree in bachelor of science with education. A cross-sectional survey utilised data from 132 undergraduate science teachers at a university of science and technology recruited by census technique. Self-report data were obtained using the COVID-19 Anxiety Scale. Descriptive and logistic regression statistics were used to analyse the data. The prevalence of COVID-19 anxiety was found at 11.36%. Career aspects in pursuing postgraduate studies and a close person with a diagnosis of COVID-19 were independent factors associated with COVID-19 anxiety. Students with an intention to pursue postgraduate studies indicated a higher likelihood of COVID-19 anxiety (AOR=4.8, 95%CI: 1.04-21.69, p < .05). Furthermore, students that had no close person diagnosed with COVID-19 indicated a lower likelihood of COVID-19 anxiety (AOR=0.1, 95%CI: 0.02-- 0.63, p < .05). Higher COVID-19 anxiety was associated with lower future academic aspirations. Hence, knowledge of acquaintance diagnosed with COVID-19 was associated with an increased chance of developing the disease.
FEATURES OF THE CLINICAL COURSE OF RETROBULBAR NEURITIS
Authors: Телеуова Т.С. , Меерманова Ж.Б. , Жумагельдиева Ф.Е. , Каиров А.Е. , Мендыбаева А.Д. , Алматкызы Ж. , Еренжан К.Е. 
Published: December 2021

В данной статье представлена особенности клинической картины ретробульбарного неврита вследствие рассеянного склероза.
This article presents the features of the clinical picture of retrobulbar neuritis due to multiple sclerosis.