bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deficiencies in Planning Interventional Trial Registration of COVID-19 in China
Authors: Li Xiaodan , Zhang Shengzhao , Zhou Yiling , Liu Ying , Zhou Youlian , Li Sheyu , Su Na 
Published: March 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic has affected the world since late 2019. The efforts to control the spread of the virus need to be supported by credible evidence. Therefore, we analyzed the rationality of the timeline and geographic distribution of COVID-19 trial registration in mainland China.Methods: We searched the Chinese Clinical Trial Registry (ChiCTR, http://www.chictr.org.cn/) and International Clinical Trials Registry Platform (ICTRP, https://www.who.int/ictrp/en/) using keywords including novel coronavirus, coronavirus pneumonia, 2019-nCoV, COVID-19, and SARS-COV-2 from 1 December 2019 to 27 April 2020 and included interventional randomized and non-randomized trials including patients with confirmed cases of COVID-19 in mainland China. The registered trials were reviewed, and data were independently extracted by two reviewers based on the inclusion criteria.Results: A total of 263 registered interventional trials were included in the study. We defined the sample size index (SI) as the total number of patients needed by the trials divided by the total number of patients diagnosed with COVID-19. A total of 84,341 patients had been diagnosed with COVID-19 in China as of 26 April 2020, and the included trials had a combined sample size of 31,156 patients (SI: 0.37). After control of the COVID-19 epidemic was achieved in China (February 18, 2020), the SI was 1.54, suggesting that the number of patients needed by the trials was greater than the number of newly diagnosed patients. The SIs in 8 out of 26 provinces in mainland China were &gt;1.Conclusions: Our results suggested a clear over registration of COVID-19 trials in China, especially after control of the pandemic was achieved, preventing the generation of high-quality evidence.
CXCL5 Has Potential to Be a Marker for Hepatocellular Carcinoma Prognosis and Was Correlating With Immune Infiltrates
Authors: Nie Yuan , Jiang Mei-chun , Liu Cong , Liu Qi , Zhu Xuan 
Published: March 2021

BackgroundsTumor microenvironment (TME) plays a crucial role in the initiation and progression of Hepatocellular Carcinoma (HCC), especially immune infiltrates. However, there is still a challenge in understanding the modulation of the immune and stromal components in TME, especially TME related genes.MethodsThe proportion of tumor-infiltrating immune cells (TICs) and the immune and stromal scores in 374 HCC patients from The Cancer Genome Atlas (TCGA) database were determined using CIBERSORT and ESTIMATE computational methods. The final screened genes were confirmed by the PPI network and univariate Cox regression of the differentially expressed genes based on different immune or stromal scores. The correlation between the expression levels of the final gene interactions and the clinical characteristics was based on TCGA database and local hospital data. Gene set enrichment analysis (GSEA) and the effect of CXCL5 expression on TICs were conducted.ResultsThere were correlations between the expression of CXCL5 and survival of HCC patients and TMN classification both in TCGA database and local hospital data. The immune-related activities were enriched in the high-expression group; however, the metabolic pathways were enriched in the low-expression group. The result of CIBERSORT analyzing had indicated that CXCL5 expression were correlated with the proportion of NK cells activated, macrophages M0, Mast cells resting, Neutrophils.ConclusionsCXCL5 was a potential prognostic marker for HCC and provides clues regarding immune infiltrates, which offers extra insight for therapeutics of HCC, however, more independent cohorts and functional experiments of CXCL5 are warranted.
Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways
Authors: Gao Lanyang , Zhu Danli , Wang Qin , Bao Zheng , Yin Shigang , Qiang Huiyan , Wieland Heinrich , Zhang Jinyue , Teichmann Alexander , Jia Jing 
Published: March 2021

The ubiquitin-specific protease 7 (USP7), as a deubiquitinating enzyme, plays an important role in tumor progression by various mechanisms and serves as a potential therapeutic target. However, the functional role of USP7 in melanoma remains elusive. Here, we found that USP7 is overexpressed in human melanoma by tissue microarray. We performed TMT-based quantitative proteomic analysis to evaluate the A375 human melanoma cells treated with siRNA of USP7. Our data revealed specific proteins as well as multiple pathways and processes that are impacted by USP7. We found that the phosphatidylinositol-3-kinases/Akt (PI3K-Akt), forkhead box O (FOXO), and AMP-activated protein kinase (AMPK) signaling pathways may be closely related to USP7 expression in melanoma. Moreover, knockdown of USP7 in A375 cells, particularly USP7 knockout using CRISPR-Cas9, verified that USP7 regulates cell proliferation in vivo and in vitro. The results showed that inhibition of USP7 increases expression of the AMPK beta (PRKAB1), caspase 7(CASP7), and protein phosphatase 2 subunit B R3 isoform (PPP2R3A), while attenuating expression of C subunit of vacuolar ATPase (ATP6V0C), and peroxisomal biogenesis factor 11 beta (PEX11B). In summary, these findings reveal an important role of USP7 in regulating melanoma progression via PI3K/Akt/FOXO and AMPK signaling pathways and implicate USP7 as an attractive anticancer target for melanoma.
Psychological Differences Among Healthcare Workers of a Rehabilitation Institute During the COVID-19 Pandemic: A Two-Step Study
Authors: Panzeri Anna , Rossi Ferrario Silvia , Cerutti Paola 
Published: March 2021

Introduction:Healthcare workers facing the threatening COVID-19 can experience severe difficulties. Despite the need to evaluate both the psychological distress and positive protective resources, brief and reliable assessment tools are lacking.Aim:Study 1 aimed at developing a new assessment tool to measure psychological distress and esteem in healthcare workers during the COVID-19 pandemic. Study 2 aimed to explore and compare the psychological reactions of healthcare workers of the COVID-19 and the non-COVID-19 wards.Methods:In Study 1, psychologists created 25 items based on their clinical experience. A preliminary qualitative evaluation selected the best 15 items for the new tool (CPI-HP) assessing the COVID-19 psychological impact with 2 scales: psychological distress and esteem. The CPI-HP was administered to 110 healthcare professionals to study its psychometric properties and the internal structure with exploratory graph analysis and confirmatory factor analysis. Study 2 compared two groups of healthcare professionals of the COVID-19 and non-COVID-19 departments.Results:In Study 1, the CPI-HP showed satisfying psychometric properties, and the two-factor structure was confirmed with good fit indices. In Study 2, the two groups of healthcare workers showed comparable levels of psychological distress and resilient coping, but the COVID-19 group displayed significantly higher esteem and appreciation of the experience.Discussion:All operators showed high psychological distress during the emergency, but the COVID-19 group reported higher resources, probably due to stronger group cohesion and greater esteem, perceived meaning, and own work value.Conclusion:Assessing the psychological distress and resources of healthcare professionals with specific tools is important. Psychological interventions should promote their psychological health.
Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19
Authors: ÖZTÜRK Tülün , ÇAVUŞOĞLU Tuğba , İNCİR Canet , TUNÇOK Yeşim 
Published: March 2021

Abstract
During COVID-19 infection, virus and host cell interactions lead to the acute production of very strong immune mediators. The clinical status caused by damage throughout the body is mostly due to excessive pro-inflammatory cytokine production from virus-induced macrophages and granulocytes. Under infectious and inflammatory conditions, clinical and experimental studies have demonstrated that hepatic and extrahepatic cytochrome P450 (CYP) enzymes and carrier proteins responsible for drug metabolism are specifically regulated by many cytokines. Downregulation of these enzymes by cytokines can cause an elevation in plasma drug levels and/or lead to adverse drug reactions and/or toxicity. Based on the knowledge of cytokine-drug interactions occurring in the infection and inflammation stage, the aim of this review was to ascertain the influence of uncontrolled cytokine release on the metabolism of drugs used alone or in combination to treat COVID-19 patients and predict drug-drug interactions causing adverse effects.
Firework and sparkler burns in paediatric patients
Authors: Ricciardello Daniel , Yang Nam Kyu , Chamberlain Kira , Holland Andrew 
Published: March 2021

Background: While the consumer sale of fireworks is illegal in New South Wales, the sale of sparklers is legal—however, both still pose a significant risk of harm in the paediatric population. Anecdotally, burns services are aware that the misuse of sparklers can result in burns but there appears to be a paucity of studies examining this incidence in the paediatric population in Australia.Method: A retrospective review of all burns related to the use of fireworks or sparklers referred to the Children’s Hospital at Westmead (CHW) Burns Unit (BU) from January 2004 to December 2019. Results: 96 patients were referred to the CHW BU with a burn as a result of a firework or sparkler. Sparklers accounted for 69 (72%) of burns, compared with 27 (28%) from fireworks. The mean age of those injured by sparklers was five years compared with eight years in the firework group. Average total body surface area (TBSA) affected for both mechanisms was similar—for sparkler burns (2.0%) firework burns (2.4%), with a range of 0.1–15 per cent. Hands were the most common area burnt in both groups comprising 41 (59%) of sparkler burns and 13 (48%) of firework burns. Twenty patients required a total of 32 visits to the operating theatre for acute management of their burns.Conclusion: This study demonstrates the potential for significant injuries as a result of fireworks and sparklers. These findings can be used to raise awareness regarding their dangers, direct targeted educational campaigns and guide safety advice regarding their use.
An underwater propulsion system with (Bi,Na,Ba) (Ti, Mn)O3 transducer
Authors: Qian Yuan , Kong Deqing , Doshida Yutaka , Aoyagi Manabu , Kurosawa Minoru Kuribayashi 
Published: March 2021

Abstract
Underwater propulsion system using PZT transducer, as a new type of underwater propulsion system, has been studied. At that time, (Bi, Na, Ba)(Ti, Mn)O3, namely BNBTM lead-free piezoelectric ceramics were noticed. Through comparative experiments, lead-free BNBTM piezoelectric ceramics are not only friendly to the environment and the human body, but it is also that the material properties of BNBTM piezoelectric ceramics are more stable than that of PZT piezoelectric ceramics. Therefore, this research mainly discusses the feasibility of using a BNBTM transducer in the underwater propulsion system by the measurement of the system’s propulsion, BNBTM transducer’s admittance characteristic, and the speed of swimmer with the underwater propulsion system.
Electron transport via a few-dopant cluster in the presence of counter-dopants in silicon nanowire transistors
Authors: Pandy Chitra , Prabhudesai Gaurang , Yamaguchi Kensuke , Ramakrishnan V N , Neo Yoichiro , Mimura Hidenori , Moraru Daniel 
Published: March 2021

Abstract
Electron transport through a few-donor cluster flanked by acceptors is studied by first-principles and semi-empirical simulations in gated Si-nanowire transistors with n
+ electrostatically-doped source/drain. Local density-of-states spectra are probed by electrical characteristics at room temperature for clarifying modifications induced by acceptor-atoms on the energy states of the few-donor cluster. It is found that acceptor-atoms located between the few-donor cluster and the leads mainly shift the cluster potential, introducing a minor distortion to its energy spectrum. The results change only weakly as the acceptor-atoms are moved towards the Si nanowire surface, and systematically depend on the number of acceptors.
Pengaruh Deep Back Massage Terhadap Intensitas Nyeri Persalinan Kala I Fase Aktif di Ruang Bersalinan Rumah Sakit Immanudin Kabupaten Kotawaringin Barat
Authors: Oktarina Jenny , Asriana Ayu , Muniarti Muniarti 
Published: March 2021

Persalinan merupakan proses menanti kelahiran yang akan dilalui seorang ibu dengan penuh rasa nyeri tetapi hal tersebut dapat teratasi dengan melakukan penekanan pada daerah sacrum secara mantap dengan telapak tangan, lepaskan dan tekan lagi atau disebut dengan deep back massage. Tujuan penelitian ini untuk menganalisis Pengaruh Deep Back Massage terhadap intensitas nyeri persalinan kala 1 fase aktif di Ruang Bersalin Rumah Sakit immanudin Kabupaten kotawaringin barat Tahun 2017.
Desain penelitian adalah penelitian Pra Eksperiment dengan pendekatan metode One Group Pra-Post Test Design. Populasinya semua ibu bersalin pada saat penelitian, dengan sampel 21 responden diambil dengan tekhnik accidental sampling. Pengumpulan data dengan observasi.
Dari hasil penelitian sebelum perlakuan hampir setengah responden mengalami nyeri berat terkontrol sebanyak 8 responden (38,1%) dan setelah perlakuan hampir setengah responden mengalami nyeri sedang sebanyak 8 responden (38,1%).
Hasil analisa data menggunakan uji-T dengan nilai p : 0,000 dan alpha: 0,05, jadi nilai p < alpha 0,05 sehingga H0 ditolak dan H1 diterima, artinya ada perbedaan intensitas nyeri persalinan sebelum dan sesudah diberikan deep back massage.
Diharapkan hasil penelitian ini dapat digunakan sebagai alternatif penurunan rasa nyeri pada persalinan dengan mudah dilakukan tanpa efek yang membahayakan dalam memberikan intervensi pada ibu selama persalinan kala I fase aktif.
Pengaruh Pendidikan Kesehatan Reproduksi Oleh Pendidik Sebaya Terhadap Pengetahuan dan Sikap Dalam Pencegahan Seks Pranikah di SMAN 1 Sukamara Kalimantan Tengah
Authors: Oktarina Jenny 
Published: March 2021

Latar Belakang: Remaja merupakan masa transisi dari anak-anak menjadi dewasa. Usia remaja berada pada rentang 10-19 tahun. Seiring dengan masa transisi, remaja mempunyai permasalahan yang kompleks. Salah satunya adalah perilaku seks pra nikah. faktor yang mempengaruhi seks pra nikah pada remaja adalah kurangnya informasi dan pengetahuan mengenai kesehatan reproduksi. Pendidikan kesehatan reproduksi merupakan salah satu cara untuk mengurangi dampak negatif dan mencegah seks pra nikah. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan kesehatan reproduksi pada pengetahuan dan sikap remaja dalam pencegahan hubungan seks pra nikah di SMAN 1 Sukamara, Provinsi Kalimantan Tengah. Metode: Penelitian ini menggunakan rancang bangun quasi experimental (eksperimental semu) jenis pre test – post test control group design. Pengambilan sampel dilakukan dengan menggunakan teknik simple random sampling. Kuesioner digunakan untuk pengumpulan data dan analisis dilakukan dengan menggunakan uji t sampel berpasangan. Pendidikan kesehatan reproduksi diberikan tiga kali. Pre test dan post test dilakukan untuk mengukur pengetahuan dan sikap. Hasil: terdapat perbedaan yang bermakna pada kelompok kontrol dan kelompok perlakuan pada pengetahuan dan sikap remaja. pengetahuan pada remaja p=0,000 (p<0,05) dan sikap pada remaja p=0,014 (p<0,05). Kesimpulan: Ada pengaruh pendidikan kesehatan reproduksi terhadap peningkatan pengetahuan dan sikap remaja di SMAN 1 Sukamara, Provinsi Kalimantan Tengah
Pengaruh Baby Gym Terhadap Peningkatan Perkembangan Bayi Usia 6 Bulan (Studi di Desa Kayangan Kecamatan Diwek Kabupaten Jombang)
Authors: Mildiana Yana Eka 
Published: March 2021

Bayi merupakan dasar dari awal kehidupan manusia dimana pertumbuhan dan perkembangan menjadi faktor utama untukmenuju tahapan berikutnya.Pada masa ini sangat bergantung dari orang tua dalam hal pemenuhan kebutuhan dasar untuk tumbuhkembangnya.Dalam merangsang pertumbuhan dan perkembangan bayi dibutuhkan stimulasi.Baby gym merupakan salah satu kegiatan yang dapat dilakukan untuk menstimulasi pertumbuhan dan perkembangan bayi. Penelitian ini bertujuan untuk mengetahui pengaruh baby gymterhadap peningkatanperkembangan bayi usia 6 bulan di desa Kayangan, Diwek Jombang.
Jenis Penelitian ini adalah Quasi eksperimen dengan pendekatan non randomized pre and post test with control group design. Sampel dalam penelitian ini adalah bayi yang berusia 6 bulan hingga 6 bulan 15 hari saat awal penelitian sebanyak 20 anak. Teknik pengambilan sampel menggunakan total sampling. Instrumen dalam penelitian ini menggunakan KPSP, meteran, dan timbangan bayi. Pengolahan data dilakukan dengan menggunakan univariat dan bivariat (uji chi square untuk mendapatkan nilai odds ratio.
Hasil penelitian menunjukkanpengaruh baby gym terhadap perkembangan dihitung dengan menggunakan rumus nilai odds ratio dengan hasil 11 kali lebih besar untuk meningkatkan kemampuan mengangkat dada, 10 kali lebih besar untuk meningkatkan kemampuan mengangkat leher.
Kesimpulan dari penelitian ini adalah terdapat pengaruh yang signifikan pemberian baby gym dalam meningkatkan perkembangan bayi yaitu meningkatkan 10 kali dalam kemampuan mengangkat dada dan 11 kali dalam meningkatkan kemampuan mengangkat leher. Ibu diharapkan sering melakukan stimulasi, ketika sedang melakukan perawatan sehari-hari serta bidan sebaiknya sering memberikan penyuluhan tentang manfaat stimulasi pada bayi.
Pengaruh Penyuluhan Baby Spa terhadap Minat Ibu dalam Pelaksanaan Baby Spa
Authors: Lestari Iffiluri 
Published: March 2021

Pendahuluan: Hasil penelitian setelah penyuluhan adalah cukup 22 (71%), baik 7 (22,6%), dan kurang 2 (6,5%). Baby Spa bermanfaat bagi bayi, tetapi banyak ibu belum melakukannya. Hasil wawancara 10 ibu bayi, 4 pernah melakukan Baby Spa, 6 belum melakukan Baby Spa. Penelitian bertujuan mengetahui pengaruh penyuluhan Baby Spa terhadap minat ibu dalam pelaksanaan Baby Spa.Desain Penelitian: pra eksperimental rancangan “one group pre test post test design” populasi Semua Ibu yang memiliki bayi usia 0-12 bulan di Desa Bandung Kecamatan Diwek Kabupaten Jombang 211 responden dan sampel Sebagian Ibu yang memiliki Bayi usia 0-12 bulan sejumlah 32 responden menggunakan proportional random sampling. Variabel Independent Penyuluhan tentang Baby Spa Variabel dependent minat ibu dalam pelaksanaan Baby Spa. Pengumpulan data editing, Scoring, Coding dan tabulating. Instrumen kuesioner analisa Uji Wilcoxon.Hasil penelitian : minat ibu dalam pelaksanaan Baby Spa di Desa Bandung kecamatan Diwek Kabupaten Jombang. Bahwa 32 responden menunjukkan sebagian besar Minat tinggi. Tinggi 22 (68,7%), sedang 6 (18,7%), rendah 4 (12,5%).dan Minat ibu dalam pelaksanaan Baby Spa sesudah penyuluhan tinggi 31 (96,9%), sedang 1 (3,1%). Uji wilcoxon didapat p-value sebesar 0,006 < @0.05 maka Hi diterima. Kesimpulannya : ada pengaruh penyuluhan Baby Spa terhadap minat ibu dalam pelaksanaan Baby Spa di Desa Bandung, Kecamatan Diwek, Kabupaten Jombang
Knowledge, Attitude, and Opinions of Egyptian Medical Students Toward Biobanking Issues
Authors: Abdelhafiz Ahmed S. , Khairy Walaa A. , Fouda Merhan A. , Labib Rania M. , Sultan Eman A. , Ziady Hany H. , Sayed Douaa M. 
Published: March 2021

ABSTRACT

Introduction
Biobanking is an emerging concept in Egypt. Medical students represent important future stakeholders in the research community. The objective of this work was to evaluate the knowledge, attitude, and opinions of Egyptian medical students toward biobanking issues.

Methods
We designed a structured survey about these issues, which was communicated online with medical students at three universities in Egypt.

Results
A total of 315 of 364 questionnaires were completed. More than half the students have heard the term “biobanking” before. Approximately 77% had a general positive attitude toward the concept of biobanking; however, only 57.7% were willing to participate with their own or family samples. The positive attitude toward donation was significantly higher in participants with negative family history of inherited diseases (p = 0.02).

Conclusion
Although some students had limited knowledge of biobanking, they had a positive attitude toward the concept in general. However, this was not reflected in a similar attitude toward donating biospecimens, especially in those with a family history of inherited disease. Moreover, they expressed concerns about data protection and samples sharing with different stakeholders. Taking all these into account, educational activities about biobanking should be given to medical students to fill the knowledge gap on the subject.
Rehearsal simulation for antenatal consults
Authors: Cheng Anita , Yuen Doris , Cristancho Sayra 
Published: March 2021

Background: Rehearsal simulations are patient-specific case-matched tasks performed immediately prior to the actual task, with the objective of improving performance.
Objective: How does rehearsal simulation for antenatal consults impact how residents learn to engage in difficult conversations with families?
Study Design: Residents in the NICU performed case-matched video recorded rehearsal simulations, followed by actual antenatal consults. The purpose of antenatal consults is to prepare parents expecting a complication with their baby before birth. Questionnaires assessed changes in resident confidence and self-assessment of communication skills. Residents were interviewed for qualitative data to explore the overall impact of rehearsal simulation on their learning and performance.
Results: Thirteen residents participated. Rehearsal simulation improved confidence with a more organized approach of medical content and better communication techniques, allowing for a shift of focus from a checklist approach to building rapport and displaying empathy.
Conclusions: While rehearsal simulation did not prepare residents for unexpected parent responses, trainees’ increased confidence with medical content organization and communication techniques created space for reflection-in-action and compassionate approaches.
Mobilizando histórias na formação inicial de educadores matemáticos: memórias, práticas sociais e jogos discursivos
Authors: Miguel Antonio , Abreu Mendes Iran 
Published: March 2021

Na primeira parte deste artigo, compartilhamos e elucidamos nossa forma particular de mobilizar histórias em algumas disciplinas dos cursos de graduação da formação de professores de matemática oferecidos pela Universidade Estadual de Campinas e pela Universidade Federal do Rio Grande do Norte, no Brasil. Essa forma de mobilização pode ser caracterizada como um conjunto de problematizações indisciplinares coletivas que incidem sobre sucessivas investigações realizadas pelos participantes desses cursos. Essas investigações tomam como objeto práticas mobilizadoras da cultura matemática. Essas práticas são realizadas por diferentes comunidades constituídas por - e constituintes de - diferentes atividades humanas. Na segunda parte deste artigo, nosso objetivo é problematizar nossa forma de mobilizar histórias, contrastando-a com a perspectiva teórica da aprendizagem expansiva, do modo como foi defendida por Yrjö Engeström, em seu artigo Non scolae sed vitae discimus - para a superação do encapsulamento da aprendizagem escolar. Vamos também destacar o papel que este pesquisador atribui à história em seu modelo de aprendizagem expansiva, perspectiva que se coloca no desenvolvimento da pesquisa contemporânea sobre a teoria da atividade.