bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caracterização físico-química do mesocarpo de maracujá amarelo osmoconvectivo em diferentes temperaturas de secagem
Authors: Santos Andrade Fabrícia , Oliveira Galdino Pablícia , Da Silva Melo Bruno Henrique , Gomes de Araújo Myrian Stefany 
Published: May 2021

Tecnologias empregadas para o reaproveitamento de resíduos têm ocupado espaço no Brasil, que é um grande produtor agroindustrial. O mesocarpo, parte interna do maracujá que envolve a polpa agrega valor nutricional, e pode ser aproveitado por uma tecnologia de desidratação osmótica e secagem convectiva, produzindo uma espécie de fruta passa. Assim, o objetivo geral foi realizar caracterização físico química do mesocarpo de maracujá amarelo in natura e osmoconvectivo, por meio dos parâmetros: pH, acidez total titulável, sólidos solúveis totais (ºBrix), teor de água/sólidos totais, cinzas, ácido ascórbico, açúcares redutores e não redutores, açucares totais, cor e atividade de água. As fatias do mesocarpo foram cortadas em de 2,5 x 1,5 cm branqueadas e em seguida, imersas em solução desidratante contendo 40, 50 e 60 ºBrix de sacarose em água destilada. Estes recipientes para cada concentração foram levados à estufa com circulação de ar nas temperaturas 40, 50 e 60 ºC por 1,5 hora, estabelecido por planejamento experimental fatorial 2² + 3 pontos centrais, com variáveis independentes, temperatura (40 a 60 °C) e concentração da solução de sacarose (40 a 60 °Brix). As fatias osmodesidratadas foram submetidas à secagem convectiva nas temperaturas de 50, 60 e 70 ºC, apresentando-se como melhor condição de preservação do ácido ascórbico, menor atividade de água e baixo teor de água, as fatias submetidas a temperatura de 60 ºC. As fatias secas a 60 °C foram consideradas a melhor amostra, pela conservação de ácido ascórbico, atividade de água abaixo de 0,6 e baixo teor de água.
“Fronteiras dos Movimentos Sociais” / "Frontiers of the Social Movements"
Authors: Szwako José Eduardo Leon , Dowbor Monika , Pereira Matheus Mazzilli 
Published: May 2021

O adensamento da produção acadêmica sobre movimentos sociais na última década no Brasil, quer nas Ciências Sociais ou ao redor delas, se expressa hoje na consolidação de redes de pesquisa e espaços de debate acadêmico em fóruns como, por exemplo, as últimas edições do Congresso Brasileiro de Sociologia e os encontros anuais da Associação Nacional de Pós-Graduação em Ciências Sociais (Anpocs). Junto a tais redes e fóruns, é possível destacar como evidência robusta desse mesmo processo o volume crescente de dossiês temáticos, bem como de artigos publicados em diálogo constante e crítico com abordagens teóricas e autores internacionais. O dossiê ora apresentado se insere nesse ritmo de adensamento, explorando, nesta apresentação e nos artigos a seguir, debates sobre fenômenos e abordagens que, há algum tempo, têm recebido crescente atenção de pesquisas de movimentos sociais, expandindo as fronteiras analítico-conceituais desse campo de estudos e, assim, desafiando-o. AbstractThe intensification in academic production on social movements in the last decade in Brazil, whether within or around the Social Sciences, is expressed today in the consolidation of research networks and spaces for academic debate in forums such as, for example, the latest editions of the Brazilian Congress of Sociology and the annual meetings of the National Association of Graduate Studies in Social Sciences (Anpocs). Along with such networks and forums, it is possible to highlight as robust evidence of this same process the growing volume of thematic dossiers, as well as articles published in constant and critical dialogue with theoretical approaches and international authors. The dossier presented here falls within this pace of intensification, exploring, in this presentation and in the following articles, debates on phenomena and approaches that, for some time, have received increasing attention from research on social movements, expanding the analytical-conceptual frontiers of this field of studies and, thus, challenging it.
OPTIMALISASI PRODUKTIVITAS ALAT GALI MUAT DAN ALAT ANGKUT PADA PT BORNEO ALAM SEMESTA, DESA SWARANGAN, KECAMATAN JORONG, KABUPATEN TANAH LAUT, KALIMANTAN SELATAN
Authors: Maulana Maulana , Saismana Uyu , Hakim Romla Noor 
Published: May 2021

PT Borneo Alam Semesta merupakan kontraktor penambangan dari PT Jorong Barutama Greston. Dalam proses pembongkaran overburden, perusahaan ini menargetkan produksi sebesar 500 BCM/jam untuk tiga fleet. Untuk memenuhi target produksi overburden tersebut, digunakan alat gali muat dan alat angkut yang terbagi dalam tiga fleet, Pada PT BAS ada rencana untuk melakukan peningkatan produksi untuk itu perlu dilakukan penelitian untuk mengetahui ada nya kemungkinan untuk meningkatkan produksi.Metode yang digunakan dalam penelitian ini adalah dengan menganalisis nilai cycle time dari alat yang beroperasi, kondisi medan kerja, serta sifat material, dan factor-faktor lainnya sehingga dapat diketahui produktivitas alat gali muat caterpillar 09, caterpillar 10, komatsu dan alat angkut dump truck nissan CWB45a secara nyata dilapangan.Perhitungan dengan data aktual diperoleh besar produktivitas alat gali muat pada tiga fleet sebesar 681,48 BCM/jam, dan untuk produktivitas alat angkut pada tiga fleet sebesar 586,89 BCM/jam. Target produksi alat mekanis sudah tercapai meskipun tidak jauh berbeda hasilnya dengan hitungan aktual dilapangan, maka dari itu dilakukan optimalisasi pada alat mekanis agar produktivitas lebih baik hasilnya, Optimalisasi pada alat gali muat dalam tiga fleet sebesar 841,67 BCM/jam, sedangkan optimalisasi untuk alat angkut dalam tiga fleet sebesar 602,31 BCM/jam. Kata Kunci : produksi, optimalisasi, alat gali muat, alat angkut
EVALUASI PRODUKTIVITAS ALAT GALI MUAT DAN ALAT ANGKUT PADA PEMINDAHAN OVERBURDEN PIT 10 DI PT BERKAT TAMBANG SEJAHTERA, KECAMATAN LOKPAIKAT, KABUPATEN TAPIN, PROVINSI KALIMANTAN SELATAN
Authors: Yulianto Agung , Santoso Eko , Putri Karina Shella 
Published: May 2021

PT Berkat Tambang Sejahtera memiliki target produktivitas overburden yang telah ditentukan yaitu sebesar 200 BCM/jam. Tidak tercapainya target perusahaan sehingga perlu adanya analisis terhadap faktor-faktor yang mempengaruhi produktivitas alat gali muat dan alat angkut di lapangan antara lain waktu siklus kerja dan waktu hambatan kerja.Penelitian ini dilakukan dengan menganalisis faktor-faktor pendukung produktivitas seperti cycle time, delay time dan geometri jalan, sehingga dapat dilakukan upaya peningkatan produktivitas agar target perusahaan dapat tercapai.Pada hasil penelitian didapatkan rata-rata produktivitas aktual Hitachi ZX470LC-5G sebesar 175 BCM/jam dan jumlah alat angkut sebanyak 6 unit didapatkan rata-rata total produktivitas aktual Hino 500 FM260JD sebesar 173,44 BCM/Jam. Upaya yang dilakukan agar target tercapai yaitu dengan melakukan simulasi perbaikan cycle time dilakukan dengan cara peningkatan kecepatan dump truck Hino 500 FM260JD pada waktu bermuatan sebesar 23 km/jam dan pada saat kosongan 28 km/jam. Perbaikan yang dapat dilakukan agar kecepatan tempuh yang ditargetkan dapat terpenuhi yaitu dengan memperhatikan kondisi jalan angkut yang dilalui pada saat muatan berisi ataupun muatan kosong. Dalam penelitian ini rekomendasi yang diberikan berupa perbaikan geometri jalan angkut seperti lebar jalan dan grade jalan. Kata kunci: produktivitas, cycle time, delay time, geometri jalan
Bidentoquinqueloculina Amaoin. Gen., n. sp., a New Recent Miliolid Foraminifer from the Arabian Gulf
Authors: Kaminski Michael A. , Fiorini Flavia 
Published: May 2021

ABSTRACTBidentoquinqueloculina amaoi, a new genus and species from modern sediments of the Arabian Gulf, is described. The new genus differs from Quinqueloculina in the presence of a second tooth on the opposite side of the aperture. The new species appears to be endemic to the Arabian Gulf.
Production of Clone-like Chicken by Primordial Germ Cells Induced From Somatic Cells
Authors: Zhao Ruifeng , Zuo Qisheng , Yuan Xia , Jin Kai , Zhang Yani , Chen Guohong , Li Bichun 
Published: May 2021

Abstract
The chicken primordial germ cell (PGCs) has the unique characteristic of settling in gonad through blood migration, which was the only way to realize the recovery of bird species. However, the PGCs obtained from a single embryo was far from enough to meet the practical application, while somatic cells can be obtained in large quantities. Therefore, the problem of insufficient PGCs can be solved by the induction of somatic cells into PGCs. Here, we successfully transdifferentiate somatic cells into PGCs, which can be transplanted to the recipient to produce offspring. In detail, The CEF of Black-Feathered Langshan Chicken was reprogrammed into iPS by reprogramming factors Oct4, Sox2, Nanog and Lin28, then was induced into PGCs by BMP4/BMP8b/EGF system. The induced PGCs has similar biological characteristics to the primary PGCs, which was transplanted into White Plymouth Rock Chicken, which self-crossed to produce clone-like offspring. It was the the first time to demonstrate the feasibility of avian cloning from somatic cells.
Hotspot DNMT3A mutations in Clonal Hematopoiesis and Acute Myeloid Leukemia sensitize cells to Azacytidine via viral mimicry response
Authors: Scheller Marina , Ludwig Anne Kathrin , Göllner Stefanie , Rohde Christian , Krämer Stephen , Stäble Sina , Janssen Maike , Müller James-Arne , He Lixiazi , Bäumer Nicole , Arnold Christian , Gerß Joachim , Schönung Maximilian , Thiede Christian , Niederwieser Christian , Niederwieser Dietger , Serve Hubert , Berdel Wolfgang E. , Thiem Ulrich , Hemmerling Inga , Leuschner Florian , Plass Christoph , Schlesner Matthias , Zaugg Judith , Milsom Micheal , Trumpp Andreas , Pabst Caroline , Lipka Daniel B. , Müller-Tidow Carsten 
Published: May 2021

Abstract
Somatic mutations in DNA Methyltransferase 3A (DNMT3A) are among the most frequent alterations in clonal hematopoiesis (CH) and Acute Myeloid Leukemia (AML), with a hotspot in exon 23 at arginine 882 (DNMT3A-R882). Here we demonstrate that DNMT3A-R882H-dependent CH- and AML cells are specifically susceptible to the hypomethylating agent azacytidine (AZA). Addition of AZA to chemotherapy prolonged AML survival solely in patients with DNMT3A-R882 mutation, suggesting its potential as a novel predictive marker for AZA response. AML and CH mouse models confirmed AZA susceptibility specifically in DNMT3A-R882H-expressing cells. Hematopoietic stem and progenitor cells expressing DNMT3A-R882H exhibited cell-autonomous viral mimicry response as a result of focal DNA hypomethylation at retrotransposon sequences. Administration of AZA boosted hypomethylation of retrotransposons specifically in DNMT3A-R882H expressing cells and maintained elevated levels of canonical interferon-stimulated genes (ISGs), thus leading to suppressed protein translation and increased apoptosis.
Study protocol for a feasibility trial in community pharmacy of a personalised behaviour change intervention to reduce reliever reliance and overuse in individuals with asthma.
Authors: Foot Holly , Beyene Kebede , Horne Rob , Fingleton James , Harrison Jeff , Chan Amy 
Published: May 2021

Abstract
BackgroundIn patients with asthma, over-reliance and overuse of short-acting beta2 agonist (SABA) is common and associated with increased morbidity and mortality. Patient beliefs are a key driver of inappropriate reliever use. A recently developed, brief, online intervention has been shown to identify and shift patient beliefs that drive inappropriate reliever use. Whether this intervention works to shift beliefs in individuals with asthma when delivered by community pharmacists is unknown. ObjectiveTo investigate the feasibility and acceptability of a brief community pharmacist-delivered behavior change intervention, and its effect on beliefs about SABA and SABA use in patients with asthma. MethodsThis is a non-randomised, before- and after- study of 120 individuals aged 18 years and older, prescribed a SABA for their asthma symptoms, presenting to one of two enrolled community pharmacies in Auckland, New Zealand. At enrolment, all participants will complete the SABA Reliance Questionnaire (SRQ), Asthma Control Test and 5-item Medication Adherence Report Scale via an online survey platform. Control participants will receive usual asthma care from their community pharmacy. Intervention participants will receive the intervention to shift any misplaced beliefs about SABA, comprising the SRQ to identify individual beliefs about SABA, then personalized information and discussion between pharmacist and patient based on the specific responses to the questionnaires. Those on SABA monotherapy and/or are at risk of SABA overuse will be referred to the general practitioner. Effect on beliefs about SABA and actual SABA use will be assessed by the SRQ and dispensing records, respectively. Feasibility will be evaluated through participant recruitment and retention rates, intervention fidelity, appropriateness and procedures of outcome measures pre- and post-intervention, and acceptability by obtaining feedback from participants (both patients and pharmacists) on the intervention.
A detailed and radioisotope-free protocol for electrophoretic mobility shift assay (EMSA)
Authors: NGUYEN NGUYEN HOAI 
Published: May 2021

Abstract
To comprehensively characterize the functions of a transcription factor (TF), it is required to analyze the interaction of this TF with its targeted loci. Several methods such as β-glucuronidase (GUS) or luciferase reporter, yeast one-hybrid (Y1H), chromatin-immunoprecipitation (ChIP), and electrophoretic mobility shift assay (EMSA) assays have been developed. Of these, EMSA is an in vitro method which can prove the direct interaction between TF and targeted DNA fragment. This protocol is to provide a detailed procedure for a safe EMSA assay (without using any radioisotope).
Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma
Authors: Huang Lin , Qian Kun 
Published: May 2021

Abstract
Early cancer detection greatly increases the chances for successful treatment, but available diagnostics for some tumours, including lung adenocarcinoma (LA), are limited. An ideal early-stage diagnosis of LA for large-scale clinical use must address quick detection, low invasiveness, and high performance. Here, we conduct machine learning of serum metabolic patterns to detect early-stage LA. We extract direct metabolic patterns by the optimized ferric particle-assisted laser desorption/ionization mass spectrometry within 1 second using only 50 nL of serum. We define a metabolic range of 100-400 Da with 143 m/z features. We diagnose early-stage LA with sensitivity~70-90% and specificity~90-93% through the sparse regression machine learning of patterns. We identify a biomarker panel of seven metabolites and relevant pathways to distinguish early-stage LA from controls (p < 0.05). Our approach advances the design of metabolic analysis for early cancer detection and holds promise as an efficient test for low-cost rollout to clinics.
Application of machine learning for acoustic emissions waveform to classify galling wear on sheet metal stamping tools
Authors: Griffin James Marcus , Shanbhag Vignesh. V. , Pereira Michael. P. , Rolfe Bernard. F. 
Published: May 2021

Abstract
Galling wear in sheet metal stamping processes can degrade the product quality and adversely affect mass production. Studies have shown that acoustic emission sensors can be used to measure galling. In the literature, attempts have been made to correlate the acoustic emission features and galling wear in the sheet metal stamping process. However, there is very little attempt made to implement machine learning techniques to detect acoustic emission features that can classify non-galling and galling wear as well as provide additional wear-state information in the form of strong visualisations. In the first part of the paper time domain and frequency domain analysis are used to determine the acoustic emission features that can be used for unsupervised classification. Due to galling wear progression on the stamping tools, the behaviour of acoustic emission waveform changes from stationary to a non-stationary state. The initial change in acoustic emission waveform behaviour due to galling wear initiation is very difficult to observe due to the ratio of change against the large data size of the waveform. Therefore, a time-frequency technique “Hilbert Huang Transform” is applied to the acoustic emission waveform as that is sensitive to change of wear state, and is used for the classification of ‘non galling’ and the ‘transition of galling’. Also, the unsupervised learning algorithm fuzzy clustering is used as comparison against the supervised learning techniques. Despite not knowing a priori the wear state labels, fuzzy clustering is able to define three relatively accurate distinct classes: “unworn”, “transition to galling”, and “severe galling”. In the second part of the paper, the acoustic emission features are used as an input to the supervised machine learning algorithms to classify acoustic emission features related to non-galling and galling wear. An accuracy of 96% was observed for the prediction of non-galling and galling wear using Classification, Regression Tree (CART) and Neural Network techniques. In the last part, a reduced Short Time Fourier Transform of top 10 absolute maximum component acoustic emission feature sets that correlates to wear measurement data “profile depth” is used to train and test supervised Neural Network and CART algorithms. The algorithms predicted the profile depth of 530 unseen parts (530 unseen cases), which did not have any associated labelled depth data. This shows the power of using machine learning techniques that can use a small data training set to provide additional predicted wear-state on a much larger data set. Furthermore, the machine learning techniques presented in this paper can be used further to develop a real-time measurement system to detect the transition of galling wear from measured acoustic emission features.
Severity: A QoS-aware approach to cloud application elasticity
Authors: Tsagkaropoulos Andreas , Verginadis Yiannis , Papageorgiou Nikos , Paraskevopoulos Fotis , Apostolou Dimitris , Mentzas Gregoris 
Published: May 2021

Abstract
While a multitude of cloud vendors exist today offering flexible application hosting services, the application adaptation capabilities provided in terms of autoscaling are rather limited. In most cases, a static adaptation action is used having a fixed scaling response. In the cases that a dynamic adaptation action is provided, this is based on a single scaling variable. We propose Severity, a novel algorithmic approach aiding the adaptation of cloud applications. Based on the input of the DevOps, our approach detects situations, calculates their Severity and proposes adaptations which can lead to better application performance. Severity can be calculated for any number of application QoS attributes and any type of such attributes, whether bounded or unbounded. Evaluation with four distinct workload types and a variety of monitoring attributes shows that QoS for particular application categories is improved. The efficacy of our approach is demonstrated with a prototype implementation of an application adaptation manager, for which the source code is provided.
Comparative Analyses of 35 Complete Chloroplast Genomes from the Genus Dalbergia (Fabacaeae) and the Identification of DNA Barcodes for Tracking Illegal Logging and Counterfeit Rosewood
Authors: Hong Zhou , Peng Dan , He Wenchuang , Zhang Ningnan , Yang Zengjiang , Tembrock Luke R , Wu Zhiqiang , Liao Xuezhu , Xu Daping 
Published: May 2021

Abstract
The genus Dalbergia contains more than 120 species several of which are trees that produce traditional medicines and extremely high value timber commonly referred to as rosewood. Due to the rarity of these species in the wild, the high value of the timber, and a growing international illicit trade CITES has listed the entire genus in appendix II and the species D. nigra in appendix I because it is considered threatened with extinction. Given this and the fact that species or even genus level determination is nearly impossible from cut timber alternative molecular methods are needed to identify and track intercepted rosewood. In order to improve molecular identification of rosewood, we sequenced and assembled eight chloroplast genomes including D. nigra as well as conducted comparative analyses with all other available chloroplast genomes in Dalbergia and closely related lineages. From these analyses numerous repeats including simple sequence repeats (SSR) and conserved nucleotide polymorphisms unique to subclades within the genus were detected. From phylogenetic analysis using the CDS of 77 coding genes the groups Siam rosewood and scented rosewood based mainly on wood characteristics were supported as monophyletic. In addition, several instances of paraphyly and polyphyly resulting from mismatch between taxonomic determinations and phylogenetic tree topology were identified. Ultimately, the highly variable regions in the chloroplast genomes will provide useful plastid markers for further studies regarding the identification, phylogeny, and population genetics of Dalbergia species including those frequently intercepted in illegal trade.
Specifics of Determination of Human Biological Age by Blood Samples Using Epigenetic Markers
Authors: Kipen Viachaslau , Bahdanava Maryna , Burakova Aryna , Dobysh Olga , Zotova Olga , Bulgak Aleksandr , Lemesh Valentina 
Published: May 2021

Abstract
Our research focused on the selection of already known markers, as well as the search for other infonormative markers based on data made publicly available on the GEO NCBI platform (genome-wide DNA methylation projects using the Infinium Human Methylation 450K BeadChip (Illumina ©)). The main objective of the study was to demonstrate that the accuracy of determining the biological age of a person in the presence of chronic diseases using linear-dependent methylation markers is comparable to the accuracy of determining the biological age of a healthy person. Criminologists, as a rule, do not have information about the chronic diseases of a person who has left a biological trace at the scene (blood, for example). However, the lack of this information, as we have shown for a some of diseases, does not play a critical role in the precise determination of biological age. Additionally, an obstacle was removed when transferring the information content of markers from Infinium Human Methylation 450K BeadChip chips to SNaPshot technology. The analysis was carried out on a sample of 236 Belarusians, for whom the methylation profile for 7 Cpg markers is presented. It is shown that the information content of markers is preserved Our analysis shows the possibility of creating the universal test system for predicting biological age according to marker methylation. The system can be used in the work of the most criminalist in the world with the same task.