bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Study of the Safety and Efficacy of Anlotinib Combined With Dose-Dense Temozolomide in Patients With Recurrent Glioblastoma
Authors: She Lei , Su Lin , Shen Liangfang , Liu Chao 
Published: July 2021

PurposeThe purpose of this study was to retrospectively analyze the safety and clinical efficacy of anlotinib combined with dose-dense temozolomide (TMZ) as the first-line therapy in the treatment of recurrent glioblastoma (rGBM).Patients and MethodsWe collected the clinical data of 20 patients with rGBM. All patients received anlotinib (12 mg daily, orally for 2 weeks, discontinued for 1 week, repeated every 3 weeks) combined with dose-dense TMZ (100 mg/m2, 7 days on with 7 days off) until the disease progressed (PD) or adverse effects (AEs) above grade 4 appeared. Grade 3 AEs need to be restored to grade 2 before continuing treatment, and the daily dose of anlotinib is reduced to 10 mg. The patients were reexamined by head magnetic resonance imaging (MRI) every 1 to 3 months. The therapeutic effect was evaluated according to Response Assessment in Neuro-Oncology (RANO) criteria. The survival rate was analyzed by Kaplan-Meier survival curve analysis. The baseline of all survival index statistics was the start of anlotinib combined with dose-dense of TMZ. National Cancer Institute-Common Terminology Criteria Adverse Events version 4.0 (NCI-CTCAE 4.0) was used to evaluate AEs.ResultsTwenty cases of rGBM were evaluated according to the RANO criteria after treatment with anlotinib and dose-dense TMZ, including five cases of stable disease (SD), thirteen cases of partial response (PR), one case of complete response (CR), and one case of PD. The median follow-up time was 13.4 (95% CI, 10.5–16.3) months. The 1-year overall survival (OS) rate was 47.7%. The 6-month progression-free survival (PFS) rate was 55%. In the IDH wild type group, the median PFS and median OS were 6.1 and 11.9 months, respectively. We observed that AEs associated with treatment were tolerable. One patient stopped taking the drug because of cerebral infarction. There were no treatment-related deaths.ConclusionAnlotinib combined with dose-dense TMZ for the first-line therapy showed good efficacy in OS, PFS, ORR, and DCR in the treatment of rGBM, and the AEs were tolerant. Randomized controlled clinical trials investigating the treatment of rGBM with anlotinib are necessary.
Early Cumulative Fluid Balance and Outcomes in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients With Acute Respiratory Failure: A Multicenter Study
Authors: Sallee Colin J. , Smith Lincoln S. , Rowan Courtney M. , Heckbert Susan R. , Angelo Joseph R. , Daniel Megan C. , Gertz Shira J. , Hsing Deyin D. , Mahadeo Kris M. , McArthur Jennifer A. , Fitzgerald Julie C. 
Published: July 2021

ObjectivesTo evaluate the associations between early cumulative fluid balance (CFB) and outcomes among critically ill pediatric allogeneic hematopoietic cell transplant (HCT) recipients with acute respiratory failure, and determine if these associations vary by treatment with renal replacement therapy (RRT).MethodsWe performed a secondary analysis of a multicenter retrospective cohort of patients (1mo - 21yrs) post-allogeneic HCT with acute respiratory failure treated with invasive mechanical ventilation (IMV) from 2009 to 2014. Fluid intake and output were measured daily for the first week of IMV (day 0 = day of intubation). The exposure, day 3 CFB (CFB from day 0 through day 3 of IMV), was calculated using the equation [Fluid in – Fluid out] (liters)/[PICU admission weight](kg)*100. We measured the association between day 3 CFB and PICU mortality with logistic regression, and the rate of extubation at 28 and 60 days with competing risk regression (PICU mortality = competing risk).Results198 patients were included in the study. Mean % CFB for the cohort was positive on day 0 of IMV, and increased further on days 1-7 of IMV. For each 1% increase in day 3 CFB, the odds of PICU mortality were 3% higher (adjusted odds ratio (aOR) 1.03, 95% CI 1.00-1.07), and the rate of extubation was 3% lower at 28 days (adjusted subdistribution hazard ratio (aSHR) 0.97, 95% CI 0.95-0.98) and 3% lower at 60 days (aSHR 0.97, 95% CI 0.95-0.98). When day 3 CFB was dichotomized, 161 (81%) had positive and 37 (19%) had negative day 3 CFB. Positive day 3 CFB was associated with higher PICU mortality (aOR 3.42, 95% CI 1.48-7.87) and a lower rate of extubation at 28 days (aSHR 0.30, 95% CI 0.18-0.48) and 60 days (aSHR 0.30, 95% 0.19-0.48). On stratified analysis, the association between positive day 3 CFB and PICU mortality was significantly stronger in those not treated with RRT (no RRT: aOR 9.11, 95% CI 2.29-36.22; RRT: aOR 1.40, 95% CI 0.42-4.74).ConclusionsAmong critically ill pediatric allogeneic HCT recipients with acute respiratory failure, positive and increasing early CFB were independently associated with adverse outcomes.
Pharmacotherapy for Behçet’s Disease and the Risk of Malignancy
Authors: Huang Mao-Xin , Wang Cai-Yun , Guo Jin-Yan , Li Jian-Hao , Li Xiao-Hong , Zhang Jiang-An , Yu Jian-Bin 
Published: July 2021

Background: Behçet’s disease (BD) is associated with an increased risk of cancer. Few reports have been published on the relationship between drug exposure and the risk of cancer in patients with BD. Herein, we explored the relationship between pharmacologic interventions for BD and the risk of cancer.Methods: we carried out a retrospective nested case-control study in a cohort of BD patients from attending our institution. Among 1,148 patients, 22 cancer patients were individually 1:2 matched to 44 cancer-free controls. The following biochemical indicators were evaluated: routine blood analysis, liver and kidney function tests, inflammatory indexes, blood gas analysis, blood electrolyte and previous pharmacologic interventions to manage BD including systemic glucocorticoids, methotrexate, cyclosporine-A, azathioprine, cyclophosphamide (CYC), and thalidomide, which are considered the primary medicines used for the management of BD.Results: Among the 22 BD patients with cancers, myelodysplastic syndrome (MDS) (22.72%) was the most common type. Furthermore, CYC administration was significantly higher in BD patients with cancer compared with the cancer-free matched control group. Further, we observed that complement 4 (C4) (odds ratio [OR] = 0.0001, 95% confidence interval [CI]: 0.001–0.065) and hemoglobin (Hb) (OR = 0.891, 95% CI: 0.795–0.998) levels were independent protective factors for predicting cancer risk in BD patients on multivariate analyses.Conclusion: Our study revealed that CYC was associated with a high risk of cancer in BD patients. Furthermore, C4 and Hb are independent protective factors for oncogenesis in BD patients. These findings may provide references and suggestions for clinicians to select appropriate treatments and for the early recognition of high-risk patients to reduce cancer incidence in BD patients.
Medicinal Plants Used for Treating Mild Covid-19 Symptoms Among Thai Karen and Hmong
Authors: Phumthum Methee , Nguanchoo Varangrat , Balslev Henrik 
Published: July 2021

Background: The COVID-19 pandemic is causing many severe problems globally, and it is not known for how long it will last. The only hope we have for dealing with the problem is to produce sufficient vaccines and administer them efficiently. However, the current demand for vaccines greatly exceeds the supply, and many people will suffer from the disease for still some time. Moreover, the period for immunity obtained by the vaccines remains unknown, and we cannot predict how long the world will suffer the COVID-19 infections. Therefore, there will be a continued demand for treatments of its symptoms. An alternative solution for providing such treatment is the use of traditional medicinal plants.Aims: To document medicinal plants used by Hmong and Karen in Thailand to treat mild symptoms of COVID-19.Methods: Traditional knowledge about ethnomedicinal plants used by Hmong and Karen in Thailand for treating mild symptoms listed by WHO as associated with COVID 19, was collected in field interviews and extracted from the literature.Results: We identified 491 plant species used medicinally by both ethnic groups to treat fever, cough, diarrhea, muscle pain and ache, rash, headache, sore throat, and conjunctivitis. Of the 491 species 60 were mentioned at least five times in the literature or in our field data. Of these 60 species, we propose the most commonly used ones for treatments of mild COVID-19 symptoms. Ten of these most commonly mentioned species were used for treatments of fever, nine for treatment of cough, four for treatment of diarrhea, two for treatment of rash, and a single species was used to treat muscle pain and headache.Conclusion: This study suggests alternative treatments for mild symptoms of COVID-19 with medicinal plants that are traditionally used by the ethnic minority groups of the Hmong and Karen in Thailand. Although COVID-19 is a new disease, its mild symptoms are shared with many other diseases. Traditional knowledge on medicinal plants used by the Thai Karen and Hmong could help in the treatments of these symptoms associated with COVID-19. Many of the proposed plants were used abundantly by both ethnic groups, and other studies on biological activities support their efficacy in such treatments.
Diarylpentanoid (1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one) (MS13) Exhibits Anti-proliferative, Apoptosis Induction and Anti-migration Properties on Androgen-independent Human Prostate Cancer by Targeting Cell Cycle–Apoptosis and PI3K Signalling Pathways
Authors: Abd. Wahab Nurul Azwa , Abas Faridah , Othman Iekhsan , Naidu Rakesh 
Published: July 2021

Diarylpentanoids exhibit a high degree of anti-cancer activity and stability in vitro over curcumin in prostate cancer cells. Hence, this study aims to investigate the effects of a diarylpentanoid, 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (MS13) on cytotoxicity, anti-proliferative, apoptosis-inducing, anti-migration properties, and the underlying molecular mechanisms on treated androgen-independent prostate cancer cells, DU 145 and PC-3. A cell viability assay has shown greater cytotoxicity effects of MS13-treated DU 145 cells (EC50 7.57 ± 0.2 µM) and PC-3 cells (EC50 7.80 ± 0.7 µM) compared to curcumin (EC50: DU 145; 34.25 ± 2.7 µM and PC-3; 27.77 ± 6.4 µM). In addition, MS13 exhibited significant anti-proliferative activity against AIPC cells compared to curcumin in a dose- and time-dependent manner. Morphological observation, increased caspase-3 activity, and reduced Bcl-2 protein levels in these cells indicated that MS13 induces apoptosis in a time- and dose-dependent. Moreover, MS13 effectively inhibited the migration of DU 145 and PC-3 cells. Our results suggest that cell cycle-apoptosis and PI3K pathways were the topmost significant pathways impacted by MS13 activity. Our findings suggest that MS13 may demonstrate the anti-cancer activity by modulating DEGs associated with the cell cycle-apoptosis and PI3K pathways, thus inhibiting cell proliferation and cell migration as well as inducing apoptosis in AIPC cells.
Understanding Experiences of Fibromyalgia Patients Involved in the Fimouv Study During COVID-19 Lockdown
Authors: Colas Claire , Jumel Audrey , Vericel Marie-Pierre , Barth Nathalie , Manzanares Jessica , Goutte Julie , Fontana Luc , Féasson Léonard , Hupin David , Guyot Jessica 
Published: July 2021

Introduction:The COVID-19 pandemic implied a period of lockdown for the general population, increasing the risk to develop some physical or mental disorders. In fibromyalgia patients, these disorders are part of the large clinical picture of the syndrome. Fibromyalgia management is especially based on a regular practice of physical activity. Lockdown imposed a break in rhythms, requiring a restructuring of scheduling. Thus, the present study aimed to investigate the experiences of fibromyalgia patients during COVID-19 lockdown using a qualitative analysis.Method:19 patients (52 ± 9 years old) who completed a 3-month therapeutic education and/or supervised physical activity program were invited to participate (Fimouv study, Trial registration: ClinicalTrials.gov NCT04107948). A sociologist collected data by means of semi-structured interviews and analyzed them using thematic content analysis.Results:Lockdown exacerbated the main symptoms of fibromyalgia, but adjusting the rhythms of life to fluctuations of these symptoms allowed a better quality of life. Patients felt the lack of physical activity and 68% found alternatives to remain physically active. The reduction of social constraints allowed them to better contend with their pathology. Fibromyalgia stopped being a main priority.Conclusion:Lockdown was positively experienced by fibromyalgia patients. They linked the absence of physical activity with increased pain and fatigue. Nevertheless, reducing social constraints could be a key for fibromyalgia management, where symptoms seemed to take less space in everyday life.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT04107948.
MR Imaging of Cochlear Modiolus and Endolymphatic Hydrops in Patients With Menière's Disease
Authors: Sousa Rita , Guerreiro Carla , Eça Tiago , Campos Jorge , Luis Leonel 
Published: July 2021

Background: Menière's disease (MD) is an inner ear disorder characterized by recurrent episodes of spontaneous vertigo, unilateral low-frequency sensorineural hearing loss, tinnitus, and aural fullness. Current diagnosis still often has to rely on subjective and audiometric criteria only, although endolymphatic hydrops is recognized as the pathophysiological substrate of the disease, having been demonstrated in anatomical pathological studies and by magnetic resonance (MRI). The modiolus has a close functional and anatomical relationship with the cochlear nerve and membranous labyrinth and can be evaluated with MRI but no data exist on the modiolar size in MD.Purpose: Our purpose is to examine the following hypothesis. Is cochlear modiolus smaller in symptomatic ears in MD?Methods: We used a retrospective 3 Tesla MR study (heavily T2-weighted 3D fast asymmetric spin-echo images and 0.5 mm slice thickness) comparing the mean modiolar area (MMA) in the index and best ears of eight patients with definite MD based on audiometric data. The obtained MMA values were compared against the audiometric data and the presence of vestibular endolymphatic hydrops.Results: No differences were seen in MMA between best and worst ears. Ears with a pure tone average (PTA) ≥25 dB and more pronounced endolymphatic hydrops showed lower MMA (not statistically significant). Two patients with extreme endolymphatic hydrops showed a noteworthy ipsilateral decrease in the cochlear modiolus area.Conclusion: No differences were seen in MMA between best and worst ears in definite MD. Worse hearing function (PTA ≥ 25dB) and more pronounced endolymphatic hydrops seem to be associated with lower MMA. This might be related to bone remodeling as a consequence of endolymphatic hydrops. Further research is needed to corroborate and explore these findings.
Classroom Immigrant Density Predicts Psychological Well-Being Among Adolescents With an Immigration Background: Findings From the 2017/18 Swedish Health Behaviour in School-Aged Children Study
Authors: Granvik Saminathen Maria , Löfstedt Petra , Låftman Sara Brolin 
Published: July 2021

Objectives:Group-level characteristics in shared contexts such as schools may affect adolescent psychological health. This study examined if the immigrant density in the classroom was associated with the level of self-reported psychological complaints among students with an immigration background.Methods:Cross-sectional data were derived from 2,619 lower secondary school students (aged 13–15) in the 2017/18 wave of the Swedish Health Behaviour in School-aged Children (HBSC) survey. Using multilevel analysis estimating two-level random intercept linear regression models, classroom immigrant density was considered as a potential predictor of immigrant students’ psychological complaints.Results:Students with an immigration background reported significantly fewer psychological complaints, on average, than students without such a background, even when adjusting for other sociodemographic characteristics. A cross-level interaction indicated that both first- and second-generation immigrant students experienced fewer psychological complaints in immigrant-dense classes compared to when the proportion of immigrant students was lower.Conclusion:Students with an immigration background fare better psychologically in classes with a higher proportion of immigrant students. Such compositional effects could be alleviated by strengthening all schools’ capacities to provide a more inclusive classroom climate.
Antiviral Effect of Budesonide against SARS-CoV-2
Authors: Heinen Natalie , Meister Toni Luise , Klöhn Mara , Steinmann Eike , Todt Daniel , Pfaender Stephanie 
Published: July 2021

Treatment options for COVID-19, a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, are currently severely limited. Therefore, antiviral drugs that efficiently reduce SARS-CoV-2 replication or alleviate COVID-19 symptoms are urgently needed. Inhaled glucocorticoids are currently being discussed in the context of treatment for COVID-19, partly based on a previous study that reported reduced recovery times in cases of mild COVID-19 after inhalative administration of the glucocorticoid budesonide. Given various reports that describe the potential antiviral activity of glucocorticoids against respiratory viruses, we aimed to analyze a potential antiviral activity of budesonide against SARS-CoV-2 and circulating variants of concern (VOC) B.1.1.7 (alpha) and B.1.351 (beta). We demonstrate a dose-dependent inhibition of SARS-CoV-2 that was comparable between all viral variants tested while cell viability remains unaffected. Our results are encouraging as they could indicate a multimodal mode of action of budesonide against SARS-CoV-2 and COVID-19, which could contribute to an improved clinical performance.
El Impacto del COVID en los estudiantes universitarios
Authors: Soto Rodríguez Ivan , Coaquira Nina Frida Rosa 
Published: July 2021

En esta investigación se buscó evaluar el impacto de COVID-19 en aspectos en la vida estudiantil de los estudiantes universitarios de la Universidad Nacional Agraria La Molina (UNALM), en el semestre 2020-I. Los Aspectos que fueron analizados son: los aspectos Psicológicos, el aspecto de conectividad y virtualidad y por último el aspecto económico. En el estudio se planteó un cuestionario, el cual fue aplicado en forma virtual a una muestra de los estudiantes.
En la investigacion se presentan resultados aplicados con Dass 21; y de las preguntas realizadas en relacion a la situación de conectividad disponible en sus entornos, también la situación económica familiar, se incluyó el análisis y las conclusiones a las que se llegaron, mostrando así: como afectó la Covid-19 en el aspecto psicológico de los estudiantes, como afectó a la economía familiar y las condiciones de conectividad en medio de una pandemia que no estaba prevista y que obligó a la población a adecuarse según sus posibilidades.
Um ponto cego no projeto moderno de Jürgen Habermas
Authors: Fiori Arantes Otília Beatriz , Arantes Paulo Eduardo 
Published: July 2021

Redigido em 1990, o presente escrito é uma versão ampliada a quatro mãos de um estudo original de Otília Arantes, apresentado com o mesmo título no Simpósio Internacional “Brasil Século XXI”, em novembro de 1988, na Unicamp. As datas importam também por remeter a todo um debate transcorrido ao longo dos anos 80 sobre a flagrante incongruência da exceção aberta por Jürgen Habermas ao Movimento Moderno, no mesmo momento em que o filósofo declarava obsoleto o paradigma da produção, chancelando a tremenda reestruturação produtiva que estava mudando para pior a cara do capitalismo. Fica ainda mais incompreensível a operação de salvamento preconizada por Habermas, sabendo-se que o Movimento da Arquitetura Moderna nada mais era do que a mais abrangente e acabada personificação da Utopia Técnica do Trabalho e da civilização estético-maquinista do século XX. Ignorando os ímpetos sistêmicos de todo aqueles impulsos que tornavam funcional a utopia de fundir num só bloco o viés estético do Construtivismo às mais elementares finalidades sociais, Habermas foi multiplicando distinções categoriais ad hoc enquanto descrevia o esgotamento do Estado Social, do qual justamente a Ideologia do Plano era mais do que fachada legitimadora, na verdade coluna de sustentação de qualquer iniciativa urbanística. A tentativa de identificação das razões de tamanho disparate histórico foi sem dúvida o disparador do presente estudo acerca do envelhecimento estrutural do Movimento Moderno. O desencaixe que Habermas não viu, ou por outra, a funcionalização integral que lhe escapou e converteu em apologia cega, saltava aos olhos, era a evidência mesma, para qualquer um, armado pelo espírito crítico local, que se dispusesse a examinar as razões da involução formalista, entre outras anomalias, inerentes ao arco completo cumprido pelo Movimento Moderno, que a verdade daquele triunfo internacional foi aos poucos desnudando.

Palavras-chave: Habermas, Modernidade, Projeto Moderno, Movimento Moderno, Pós-modernismo, Ideologia, Arquitetura, Nova Construção, Urbanismo, Plano, Utopia, Trabalho, Ação Comunicativa, Linguistic Turn, Iluminismo, Razão, Teoria Crítica, Welfare, Brasil, Brasília, Adorno, Benjamin, Wellmer, Peter Bürger.
DELAY PREDICTION IN IOT AND TACTILE INTERNET USING MACHINE LEARNING APPROACH
Authors: АБДЕЛЛАХ А.Р. , МАХМУД О.А. , ПАРАМОНОВ А.И. , КУЧЕРЯВЫЙ А.Е. 
Published: July 2021

Предложены методы прогнозирования задержки в сетях интернета вещей и тактильного интернета при прогнозировании вперед на несколько шагов MSP (Multi-step ahead Prediction) и один шаг SSP (Single-step ahead Prediction). Использованы нелинейные авторегресионные рекуррентные нейронные сети с внешними входами NARX(NonlinearAutoregressive with Exogenous inputs) для временных рядов. Проведена оценка точности прогнозирования с помощью трех алгоритмов обучения нейронной сети (Trainlm, Traincgf, Trainrp) при использовании в качестве оценок точности прогнозирования среднеквадратичной ошибки RMSE(Root Mean Square Error) и средней абсолютной ошибки в процентах MAPE(Mean Absolute Percent Error).
In this paper, we perform the delay prediction in IoT and tactile Internet communication networks using a multistep ahead prediction (MSP) and single-step ahead prediction (SSP) with Time Series NARX (Nonlinear AutoRegressive with eXogenous inputs) Recurrent Neural Networks. The prediction accuracy has been evaluated using three neural network training algorithms (Trainlm, Traincgf, Trainrp) using the RMSE (Root Mean Square Error) and MAPE (Mean Absolute Percent Error) as predictive accuracy measure.
Derivati dei nomi dei mesi (<em>Luglio</em>)
Authors: Francalanci Lucia 
Published: July 2021

Dopo le schede dedicate ai derivati di gennaio, febbraio, marzo, aprile, maggio e giugno continuiamo la pubblicazione della nostra rubrica con la scheda relativa a luglio. Per le informazioni generali e la bibliografia si rimanda all'Introduzione.