bluuebunny/crossref_metadata_2025_split huggingface dataset:
Madrasah Promotion Strategies in the Global Work Market 4.0
Authors: Sukarman Sukarman , Raharjo Raharjo 
Published: June 2021

Students are an important element in education. Successful educational institutions are those who are successful in student recruitment. Educational institutions that are successful in student recruitment are institutions that have succeeded in gaining trust from the community. Madrasah Aliyah Matholiul Huda Jepara as one of the Islamic-style educational institutions has its own challenges in recruiting students. This madrasa is a madrasa that successfully competes with schools and other madrassas in gaining trust from the community which is marked by the success of the student recruitment program. This research attempts to reveal the strategies adopted by Madrasah Aliyah Matholiul Huda Jepara in promoting their institutions. This research is a case study research that uses a qualitative descriptive approach. This study uses interviews, observation, and documentation in collecting data. data reduction, data display, data verification and triangulation are used for data validity analysis. The findings of this study are divided into two aspects namely the method and media of promotion used. First, Madrasah Aliyah Matholiul Huda applies direct and indirect promotion methods. Second, Madrasah Aliyah Matholiul Huda uses conventional and digital (online) promotional media. This paper provides an alternative solution for madrassas who have backgrounds or problems in the recruitment of students, especially promotion strategies. The conclusion of this paper is that to be successful in recruiting students, madrassas must choose the appropriate method and media in promoting madrassas by paying attention to the SWOT analysis.
Keywords : madrasa promotion, students recruitment
Outcome of One and Two Visit Root Canal Treatment of Irreversible Pulpitis
Authors: Rahim Md Abdur , Amin Md Nurul , Mahmood Khurshid , Osmani Sibbir Ahmed , Md Faruq Abul Kalam 
Published: June 2021

Objective: The present prospective comparative clinical trial was undertaken to compare the outcomes of single and two-visit root canal treatment of irreversible pulpitis.
Methodology: This prospective study was conducted in the Department of Conservative Dentistry and Endodontics of Dhaka Dental College on patients who presented with pain due to irreversible pulpitis. Patients with single-rooted teeth with uncomplicated canal and full-formed apex having irreversible pulpitis were included. However, pregnant women or patients under treatment of antibiotics, cortiosteiods or suffering from any systemic diseases or immuno-compromised patients or patients having teeth with calcified canal or periodontal disease were excluded. A total of 80 patients who met the eligibility criteria were consecutively included and were randomly assigned to either one-visit (n = 40) or two-visit (n = 40) treatment groups. Data were kept on pulp vitality status, the presence or absence of pre-operative pain and degree of post obturation pain at 6, 12, 24, 48 hours and 1 week postoperatively. The outcome variable was intensity of pain which was measured using a visual analogue scale (VAS) as 0 = no pain, 1 = slight pain or discomfort, 2 = moderate pain relieved by analgesic, 3 = moderate to severe pain not completely relieved by analgesics and 4 = severe pain or swelling not relieved by analgesics and required unscheduled visit.
Result: Forty percent of the patients in the two-visit group did not have any pain (measured in terms of visual analogue scale) at 12 hours compared to 25% in the single visit group, although the difference did not turn significant (p = 0.580). Likewise the proportion of patients without pain in the two-visit group was considerably higher (52.5%) at 24 hours than that in the single-visit group (45%) (p = 0.852). Improvement in pain sensation was reported to be significantly higher in the two-visit group (as 95% of the patients did not complain any pain) at 48 hours than that in the single-visit group (80% of the patients did not complain any pain) (p = 0.015). None of the patients of either group complained of pain one week postoperatively.
Conclusion: Compared to single-visit, two-visit root canal treatment showed better results in terms of intensity of post-obturation pain at 12, 24 and 48 hours after root canal treatment for irreversible pulpitis.
Ibrahim Card Med J 2015; 5 (1&2): 45-48
Amelia Opie's Lemaistre Sequence and the Romantic Occasional Poem
Authors: Stokes Christopher 
Published: June 2021

The occasional poem was one of the most commonly and diversely used Romantic genres, especially in informal and sociable modalities, yet is almost entirely marginalised in scholarship. This essay uses the reflexivity of Amelia Opie's sequence of birthday poems to Elizabeth Lemaistre (1815–44) to examine the dynamics of occasionality. Precisely because Opie must repeat the occasion across the sequence, the poetics of occasionality are clarified: each poem exists as a single dated action but also part of an ongoing work. This reflexive tension between the poem's character as act and text is explored through the nature of content in occasional verse; dating and temporality; and the phenomenon of the gift poem. An analysis of the Lemaistre sequence not only helps us to understand Opie's specific uses of the occasional to articulate friendship across networks of sociable affect, but also to determine more widely relevant traits of genre – not least, occasionality as a social practice and not just a literary classification.
Novel Long Non-coding RNA Expression Profile of Peripheral Blood Mononuclear Cells Reveals Potential Biomarkers and Regulatory Mechanisms in Systemic Lupus Erythematosus
Authors: Cheng Qi , Chen Mo , Chen Xin , Chen Xiaochan , Jiang Huawei , Wu Huaxiang , Du Yan 
Published: June 2021

ObjectiveThe multisystem involvement and high heterogeneity of systemic lupus erythematosus (SLE) lead to great challenges in its diagnosis and treatment. The purpose of this study was to find new lncRNAs in peripheral blood mononuclear cells of SLE patients by transcriptome sequencing and explore their potential as biomarkers and their correlation with clinical features.Materials and MethodsTranscriptome sequencing was used to screen differentially expressed lncRNAs (DELs) and mRNAs (DEMs). The expression of these selected lncRNAs and mRNAs in SLE patients and healthy controls was verified by qPCR. DAVID and WebGestalt were used to perform enrichment analysis. Cytoscape was used to construct a protein–protein network, a coexpression network, and a competitive endogenous RNA network to reveal the regulatory mechanisms of lncRNAs at the transcriptome level.ResultsA total of 1737 DELs and 4078 DEMs were identified between SLE patients and healthy controls. Ten lncRNAs and eight genes were verified by qPCR in a larger sample set. The lncRNA NONHSAT101022.2 was significantly downregulated in SLE patients and was also significantly related to the activity and severity of disease. The upregulated genes were enriched in defense and the immune response, while the downregulated genes were mainly enriched in SLE-related pathways. Topology network analysis revealed that the lncRNAs were involved in regulation at the transcriptome level, including acting directly on mRNA or indirectly affecting gene expression by acting on miRNA.ConclusionIn this work, we identified many mRNAs and novel lncRNAs by transcriptome sequencing. The functions and regulatory mechanisms of these lncRNAs were analyzed by bioinformatic methods. The novel lncRNA NONHSAT101022.2 is significantly downregulated in SLE patients and is significantly related to the activity and severity of disease. Additionally, we propose that NONHSAT101022.2 may enhance the signal transduction of β2-AR by cis regulating LMBRD2, inducing NK cells to produce high levels of IFN-γ and thereby exacerbating SLE.
TBX20 Contributes to Balancing the Differentiation of Perivascular Adipose-Derived Stem Cells to Vascular Lineages and Neointimal Hyperplasia
Authors: Ji Yongli , Ma Yuankun , Shen Jian , Ni Hui , Lu Yunrui , Zhang Yuhao , Ma Hong , Liu Chang , Zhao Yiming , Ding Siyin , Xiang Meixiang , Xie Yao 
Published: June 2021

BackgroundPerivascular adipose-derived stem cells (PVASCs) can contribute to vascular remodeling, which are also capable of differentiating into multiple cell lineages. The present study aims to investigate the mechanism of PVASC differentiation toward smooth muscle cells (SMCs) and endothelial cells (ECs) as well as its function in neointimal hyperplasia.MethodsSingle-cell sequencing and bulk mRNA sequencing were applied for searching key genes in PVASC regarding its role in vascular remodeling. PVASCs were induced to differentiate toward SMCs and ECs in vitro, which was quantitatively evaluated using immunofluorescence, quantitative real-time PCR (QPCR), and Western blot. Lentivirus transfections were performed in PVASCs to knock down or overexpress TBX20. In vivo, PVASCs transfected with lentivirus were transplanted around the guidewire injured femoral artery. Hematoxylin–eosin (H&amp;E) staining was performed to examine their effects on neointimal hyperplasia.ResultsBulk mRNA sequencing and single-cell sequencing revealed a unique expression of TBX20 in PVASCs. TBX20 expression markedly decreased during smooth muscle differentiation while it increased during endothelial differentiation of PVASCs. TBX20 knockdown resulted in the upregulation of SMC-specific marker expression and activated Smad2/3 signaling, while inhibiting endothelial differentiation. In contrast, TBX20 overexpression repressed the differentiation of PVASCs toward smooth muscle cells but promoted endothelial differentiation in vitro. Transplantation of PVASCs transfected with TBX20 overexpression lentivirus inhibited neointimal hyperplasia in a murine femoral artery guidewire injury model. On the contrary, neointimal hyperplasia significantly increased in the TBX20 knockdown group.ConclusionA subpopulation of PVASCs uniquely expressed TBX20. TBX20 could regulate SMC and EC differentiation of PVASCs in vitro. Transplantation of PVASCs after vascular injury suggested that PVASCs participated in neointimal hyperplasia via TBX20.
An Outbreak of Carbapenem-Resistant Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Chongqing, China
Authors: Zeng Lingyi , Yang Chengru , Zhang Jisheng , Hu Kewang , Zou Jingbo , Li Jie , Wang Jianmin , Huang Wan , Yin Lining , Zhang Xiaoli 
Published: June 2021

BackgroundDue to the critical condition and poor immunity of patients, the intensive care unit (ICU) has always been the main hospital source of multidrug-resistant bacteria. In recent years, with the large-scale use of antibiotics, the detection rate and mortality of carbapenem-resistant Klebsiella pneumoniae (CRKP) have gradually increased. This study explores the molecular characteristics and prevalence of CRKP isolated from the ICU ward of a tertiary hospital in China.MethodsA total of 51 non-duplicated CRKP samples isolated from the ICU were collected from July 2018–July 2020. The enzyme production of the strains was preliminarily screened by carbapenemase phenotypic test, and drug-resistant and virulence genes were detected by PCR. The transferability of plasmid was verified by conjugation test. The minimal inhibitory concentration (MIC) was determined by microbroth dilution method and genetic diversity was detected by multilocus sequence typing and pulsed-field gel electrophoresis.ResultsblaKPC-2 was the only carbapenemase detected. The major virulence genes were uge (100%), mrkD (94.1%), kpn (94.1%), and fim-H (72.5%), while wcag, ironB, alls and magA genes were not detected. One sequence type ST1373 strain, hypervirulent K. pneumoniae (hvKP), was detected. CRKP strains were highly resistant to quinolones, cephalosporins, aminoglycosides, and polymyxin, but susceptive to tigecycline and ceftazidime–avibactam. The success rate of conjugation was 12.2%, indicating the horizontal transfer of blaKPC-2. Homology analysis showed that there was a clonal transmission of ST11 CRKP in the ICU of our hospital.ConclusionThe present study showed the outbreak and dissemination in ICU were caused by ST11 CRKP, which were KPC-2 producers, and simultaneously, also carried some virulence genes. ST11 CRKP persisted in the ward for a long time and spread among different areas. Due to the widespread dispersal of the transferable blaKPC-2 plasmid, the hospital should promptly adopt effective surveillance and strict infection control strategies to prevent the further spread of CRKP. Ceftazidime–avibactam showed high effectiveness against CRKP and could be used for the treatment of ICU infections.
The Impact of Endometriosis on Embryo Quality in in-vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis
Authors: Dongye Houjin , Ji Xiaofeng , Ma Xiaopei , Song Jialun , Yan Lei 
Published: June 2021

Background: The association between endometriosis and embryological outcomes remains uncertain. The meta-analysis aimed to evaluate the impact of endometriosis on embryo quality.Methods: A systematic review and meta-analysis was conducted to investigate the association between the endometriosis and embryo quality. Searches were performed on the three electronic databases: PubMed, EMBASE, and Web of Science. The detailed characteristics and data of the included studies were extracted. The risk ratio with 95% confidence intervals were calculated using the random and fixed effects model. The main outcome measures were high-quality embryo rate, cleavage rate, and embryo formation rate.Results: A total of 22 studies included were analyzed. Compared with the control group, women with endometriosis had a similar high-quality embryo rate (RR = 1.00; 95% CI, 0.94–1.06), a comparable cleavage rate (RR = 1.00; 95% CI, 0.97–1.02), and a similar embryo formation rate (RR = 1.10; 95% CI, 0.97–1.24). In women with stage III-IV endometriosis, there was no statistically significantly difference in high-quality embryo rate (RR = 1.02; 95% CI, 0.94–1.10), cleavage rate (RR = 1.00; 95% CI, 0.98–1.02), and embryo formation rate (RR = 1.05; 95% CI, 0.97–1.14), compared with those without endometriosis. For women with unilateral endometrioma, pooling of results from the affected ovaries did not show a statistically significantly difference in high-quality embryo rate (RR = 0.99; 95% CI, 0.60–1.63) in comparison to the normal contralateral ovaries.Conclusions: Our results seem to indicate that endometriosis does not compromise embryo quality from the perspective of morphology.
Functional Status After Pulmonary Rehabilitation as a Predictor of Weaning Success and Survival in Patients Requiring Prolonged Mechanical Ventilation
Authors: Keng Li-Ta , Liang Sheng-Kai , Tseng Chi-Ping , Wen Yueh-Feng , Tsou Ping-Hsien , Chang Chia-Hao , Chang Lih-Yu , Yu Kai-Lun , Lee Meng-Rui , Ko Jen-Chung 
Published: June 2021

Background: Comprehensive rehabilitation programs are recommended for patients with prolonged mechanical ventilation (PMV) to facilitate functional recovery and ventilator weaning, but whether the functional status after rehabilitation influences outcome has not been clearly evaluated. This study aimed to investigate the association between post-rehabilitation functional status and weaning and survival outcome in PMV patients.Methods: We retrospectively enrolled PMV patients admitted to the respiratory care center (RCC), a post-ICU weaning facility with protocolized rehabilitation program, from January 2016 through December 2017. Functional status was measured by the de Morton Mobility Index (DEMMI), with a cut-off value set at 20 points. The primary outcomes were the weaning status at RCC discharge and hospital survival. The secondary outcomes were overall survival and survival at 3 months after RCC discharge. We followed patients until 3 months after RCC discharge or death. Logistic and Cox regressions were performed to identify significant parameters associated with weaning success and survival.Results: In total, 320 patients were enrolled. The weaning success rate was 71.6%. The survival rate at RCC discharge, hospital discharge, and 3 months after RCC discharge was 89.1, 77.5, and 66.6%, respectively. Post-rehabilitation DEMMI ≥ 20 (odds ratio [OR], 3.514; 95% confidence interval [CI], 1.436–8.598; P = 0.006) was the most significantly associated with weaning success. The weaning success and higher post-rehabilitation DEMMI were the two most significant independent factors associated with both hospital survival (weaning success, OR, 12.272; 95% CI, 5.281–28.517; P &lt; 0.001; post-rehabilitation DEMMI ≥ 20, OR, 6.298; 95% CI, 1.302–30.477; P = 0.022) and survival at 3 months after RCC discharge (weaning success, OR, 38.788; 95% CI, 11.505–130.762; P &lt; 0.001; post-rehabilitation DEMMI ≥ 20, OR, 4.830; 95% CI, 1.072–21.756; P = 0.040). Post-rehabilitation DEMMI ≥ 20 remained significantly association with overall survival at 3 months after RCC discharge (hazard ratio, 0.237; 95% CI, 0.072–0.785; P = 0.018).Conclusions: Post-rehabilitation functional status of PMV patients was independently associated with weaning success, as well as hospital and 3-month overall survival after RCC discharge. Post-rehabilitation, but not pre-rehabilitation, functional status was a significant parameter associated with weaning success and survival in patients requiring PMV.
Rich Club Characteristics of Alcohol-Naïve Functional Brain Networks Predict Future Drinking Phenotypes in Rhesus Macaques
Authors: Rowland Jared A. , Stapleton-Kotloski Jennifer R. , Alberto Greg E. , Davenport April T. , Epperly Phillip M. , Godwin Dwayne W. , Daunais James B. 
Published: June 2021

Purpose: A fundamental question for Alcohol use disorder (AUD) is how and when naïve brain networks are reorganized in response to alcohol consumption. The current study aimed to determine the progression of alcohol’s effect on functional brain networks during transition from the naïve state to chronic consumption.Procedures: Resting-state brain networks of six female rhesus macaque (Macaca mulatta) monkeys were acquired using magnetoencephalography (MEG) prior to alcohol exposure and after free-access to alcohol using a well-established model of chronic heavy alcohol consumption. Functional brain network metrics were derived at each time point.Results: The average connection frequency (p &lt; 0.024) and membership of the Rich Club (p &lt; 0.022) changed significantly over time. Metrics describing network topology remained relatively stable from baseline to free-access drinking. The minimum degree of the Rich Club prior to alcohol exposure was significantly predictive of future free-access drinking (r = −0.88, p &lt; 0.001).Conclusions: Results suggest naïve brain network characteristics may be used to predict future alcohol consumption, and that alcohol consumption alters functional brain networks, shifting hubs and Rich Club membership away from previous regions in a non-systematic manner. Further work to refine these relationships may lead to the identification of a high-risk drinking phenotype.
Effects of Brief Mindfulness Interventions on the Interference Induced by Experimental Heat Pain on Cognition in Healthy Individuals
Authors: Gill Louis-Nascan , Tabry Vanessa , Taylor Véronique , Lussier Maxime , Martinu Kristina , Bherer Louis , Roy Mathieu , Rainville Pierre 
Published: June 2021

Background:Pain captures attention and interferes with competing tasks demanding cognitive effort. Brief mindfulness interventions involving both conceptual learning and meditation exercises have been shown to improve attention and reduce pain sensitivity, and could potentially reduce pain interference. This study assesses the effect of a 5-day mindfulness intervention (20 min/day) on the interference produced by thermal pain on working memory performance using a 2-back task.Methods:Healthy participants were randomized into three groups exposed to mindfulness meditation training (n= 15), an active educational control intervention comprising only conceptual information on mindfulness (n= 15), or no intervention (n= 15). The two active interventions were administered in a dual-blind fashion and outcomes were assessed by research personnel blind to this allocation. Evaluation sessions were conducted before and after the interventions to assess the effect of pain on 2-back performance (pain interference). Importantly, both pain stimuli and the 2-back task were calibrated individually and in each session before assessing pain interference, thereby controlling for possible changes in baseline pain sensitivity and cognitive performance. Secondary outcomes included heat pain sensitivity, cold pain tolerance, cognitive inhibition, cognitive flexibility, and divided attention.Results:Manipulation checks confirmed that heat pain interferes with the performance of the working-memory task. Compared to the no-intervention control group, pain interference was significantly reduced following the conceptual intervention but not the meditation intervention, although a corollary analysis suggests the effect might be due to regression toward the mean caused by baseline imbalance in pain interference. Secondary outcomes also suggested an increase in pain tolerance in the conceptual learning group only.Discussion:A short mindfulness meditation intervention was insufficient to reduce pain interference but conceptual learning about mindfulness produced some unexpected benefits. Although the generalization of experimental findings to clinical pain conditions may be premature, these results highlight the importance of distinguishing the contribution of mindfulness education and meditation training in future studies. Understanding the effects of mindfulness training on pain regulation and management must take into consideration the multiple factors underlying this complex intervention.