bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies for inclusion of growth factors into 3D printed bone grafts
Authors: Longoni Alessia , Li Jun , Lindberg Gabriella C.J. , Rnjak-Kovacina Jelena , Wise Lyn M. , Hooper Gary J. , Woodfield Tim B.F. , Kieser David C. , Lim Khoon S. 
Published: June 2021

AbstractThere remains a critical need to develop new technologies and materials that can meet the demands of treating large bone defects. The advancement of 3-dimensional (3D) printing technologies has allowed the creation of personalized and customized bone grafts, with specific control in both macro- and micro-architecture, and desired mechanical properties. Nevertheless, the biomaterials used for the production of these bone grafts often possess poor biological properties. The incorporation of growth factors (GFs), which are the natural orchestrators of the physiological healing process, into 3D printed bone grafts, represents a promising strategy to achieve the bioactivity required to enhance bone regeneration. In this review, the possible strategies used to incorporate GFs to 3D printed constructs are presented with a specific focus on bone regeneration. In particular, the strengths and limitations of different methods, such as physical and chemical cross-linking, which are currently used to incorporate GFs to the engineered constructs are critically reviewed. Different strategies used to present one or more GFs to achieve simultaneous angiogenesis and vasculogenesis for enhanced bone regeneration are also covered in this review. In addition, the possibility of combining several manufacturing approaches to fabricate hybrid constructs, which better mimic the complexity of biological niches, is presented. Finally, the clinical relevance of these approaches and the future steps that should be taken are discussed.
Functional roles of female sex hormones and their nuclear receptors in cervical cancer
Authors: Lee Seoung-Ae , Baik Seunghan , Chung Sang-Hyuk 
Published: June 2021

Abstract
There has been little progress for several decades in modalities to treat cervical cancer. While the cervix is a hormone-sensitive tissue, physiologic roles of estrogen receptor α (ERα), progesterone receptor (PR), and their ligands in this tissue are poorly understood. It has hampered critical assessments of data in early epidemiologic and clinical studies for cervical cancer. Experimental evidence obtained from studies using mouse models has provided new insights into the molecular mechanism of ERα and PR in cervical cancer. In a mouse model expressing human papillomavirus (HPV) oncogenes, exogenous estrogen promotes cervical cancer through stromal ERα. In the same mouse model, genetic ablation of PR promotes cervical carcinogenesis without exogenous estrogen. Medroxyprogesterone acetate, a PR-activating drug, regresses cervical cancer in the mouse model. These results support that ERα and PR play opposite roles in cervical cancer. They further support that ERα inhibition and PR activation may be translated into valuable treatment for a subset of cervical cancers.
Online, Asynchronous Hearing Education and Research Project for Ethnically Diverse Adolescents via Interprofessional Collaboration and Electronic Service-Learning During the COVID-19 Pandemic: A Pilot Study on the Needs and Challenges
Authors: Deshpande Shruti Balvalli 
Published: June 2021

PurposeThis study discusses the creation of an online, asynchronous presentation to educate adolescents about prevention of noise-induced hearing loss (NIHL) through interprofessional collaborations and electronic service-learning (eSL) during the COVID-19 pandemic.MethodThe Hearing Education and Research (HEAR) presentation, which included activities and videos to educate a group of ethnically diverse adolescents (n= 100) on NIHL, was created by 11 doctor of audiology (AuD) students through online collaborations toward course-related eSL requirements. Adolescents responded to a baseline survey to assess hearing health–related behaviors prior to reviewing the presentation. A postprogram survey was administered 1 week after the presentation to assess change in knowledge and attitudes toward NIHL prevention. Online collaborations with schoolteachers helped with project implementation. Postreflection papers written by AuD students regarding the eSL activities were analyzed. Lastly, suggestions from a focus group of educators were included that highlight the role of interprofessional collaborations to enhance school-based hearing conservation opportunities.ResultsThe HEAR presentation resulted in changes in knowledge about NIHL among the adolescents. Postreflection papers by the AuD students indicated that the eSL activity served as a high-impact pedagogical assignment, especially during the academic challenges of the pandemic. Feedback from a focus group of schoolteachers helped outline ideas for future implementation of sustainable hearing conservation programs in school settings.ConclusionThe pilot data collected in this study serve as a proof of concept for future hearing conservation projects in school-based settings via interprofessional collaborations and by engaging university students via eSL.
Granulomatöse Kolitis bei einem Französische-Bulldogge-Welpen
Authors: Keiner Miriam , Balzhäuser Laura , Güssow Arne , Moritz Andreas 
Published: June 2021

ZusammenfassungEine 6 Monate alte Französische Bulldogge wurde aufgrund von chronischem Dickdarmdurchfall über 4 Monate vorgestellt. Die Diagnostik des überweisenden Tierarztes hatte Hinweise auf eine chronisch entzündliche Darmerkrankung ergeben, doch war die Therapie (Futtermittelumstellung, antibakterielle, anthelminthische, antiinflammatorische und immunsuppressive Medikation) erfolglos geblieben. Mittels Endoskopie sowie histologischer Untersuchung entnommener Gewebeproben wurden ausgeprägte Erosionen und Ulzerationen der Kolonschleimhaut detektiert. Durch Fluoreszenz-in-situ-Hybridisierung ließen sich invasive Escherichia coli-Bakterien in der Kolonschleimhaut und in Kolonmakrophagen nachweisen und damit eine granulomatöse Kolitis diagnostizieren. Der Hund zeigte unter 8-wöchiger Therapie mit Enrofloxacin eine vollständige Remission der klinischen Symptomatik. Diese Kasuistik beschreibt die erste erfolgreiche Behandlung einer granulomatösen Kolitis mit Enrofloxacin bei einer vergleichsweise jungen Französischen Bulldogge in Deutschland und soll den Leser für diesen Erkrankungskomplex bei (jungen) Hunden sensibilisieren.
Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions
Authors: Shaabani Ahmad , Farhid Hassan , Rostami Mohammad Mahdi , Notash Behrouz 
Published: June 2021

AbstractAn efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions. 3-Carboxamido-isobutyric acids bearing an amide bond were obtained via Bargellini multicomponent reaction from isocyanides, acetone, and chloroform in the presence of sodium hydroxide. Next, via a Passerini multicomponent-reaction strategy, a new class of depsipeptides was synthesized using the Bargellini reaction products, isocyanides, and aldehydes. The depsipeptides thus prepared have more flexible structures than their pseudopeptidic analogues.
Anterolateral Thigh Skin and Fascia in Facial Skin Defects with Trismus: Two Problems, One Solution
Authors: Panagatla Prakash , Ravula Parvathi , Praveen S. , Varagani Narsimha Rao , Srikanth R. , Appaka Jagadish Kiran 
Published: June 2021

AbstractA case series of five patients with skin loss in the lateral face with trismus that followed delayed presentation following trauma, necrotizing infection, and radiation fibrosis was treated with coronoidectomy and condylar excision to effect adequate mouth opening; the anterolateral thigh flap was used for cover and the fascia was used as an interposition graft to prevent recurrence. Two patients with more than 9 years of follow-up had an average of 40 mm interincisal opening.
An Integrated Management Paradigm for Skull Base Chordoma Based on Clinical and Molecular Characteristics
Authors: Abdallah Hussein M. , Gersey Zachary C. , Muthiah Nallammai , McDowell Michael M. , Pearce Thomas , Costacou Tina , Snyderman Carl H. , Wang Eric W. , Gardner Paul A. , Zenonos Georgios A. 
Published: June 2021

Abstract
Objective Previous work categorized skull base chordoma (SBC) into three genetic risk groups based on 1p36 and homozygous 9p21(p16) deletions, accounting for a wide variability in prognosis (A = low-risk, B = intermediate-risk, C = high-risk). However, it remains unclear how these groups could guide management.
Study Design By integrating surgical outcome and adjuvant radiation (AdjXRT) information with genetic data on 152 tumors, we sought to develop an evidence-based management algorithm for SBC.
Results Gross total resections (GTRs) were associated with improved progression free survival (PFS) in all genetic groups. For Group C tumors, GTR and AdjXRT independently contributed to PFS (multivariate Cox proportional hazard ratio [HR] = 0.14, p = 0.002, and HR = 0.40, p = 0.047, respectively). For Group B tumors, AdjXRT improved outcomes only when GTR was not feasible (log-rank p = 0.008), but not following GTR (log-rank p = 0.54). However, 24 of 25 Group A tumors underwent GTR, and AdjXRT for these did not confer any benefit (log-Rank p = 0.285). The high GTR rates in Group A could be explained by smaller tumor sizes (mean = 0.98cc/4.08cc/4.92cc for Group A/B/C, respectively, p = 0.031) and lack of invasiveness. Group A tumors were also more frequently diagnosed in young people (p = 0.002) as asymptomatic lesions (p = 0.001), suggesting that they could be precursors to tumors in higher risk groups.
Conclusion Genotypic grouping by 1p36 and homozygous 9p21(p16) deletions can predict prognosis in SBC and guide management. GTR remains the cornerstone of SBC treatment and can be sufficient without AdjXRT in low and intermediate risk tumors. Low-risk tumors are associated with a less invasive phenotype, which makes them more amenable to GTR.
Acute Groin Pain Syndrome Due to Internal Obturator Muscle Injury in a Professional Football Player
Authors: Bisciotti Gian N. , Corsini Alessandro , Cena Emanule , Bisciotti Andrea N. , Bisciotti Alessandro L. , Belli Andrea , Volpi Piero 
Published: June 2021

AbstractTraumatic groin pain syndrome is the result of an acute trauma, usually an indirect muscle injury (i.e., an overstretching of the muscle fibers). The most affected muscles in traumatic groin pain syndrome are rectus abdominis, adductors, and iliopsoas. The internal obturator muscle lesion is very rare. The internal obturator muscle externally rotates the thigh and contributes to the stabilization of the hip joint and its indirect injury may cause the onset of traumatic groin pain syndrome. This case report describes a rare indirect injury of internal obturator in a 29-year-old professional male soccer player.
Hip and Groin Pain in Soccer Players
Authors: Candela Vincenzo , De Carli Angelo , Longo Umile Giuseppe , Sturm Sofia , Bruni Giorgio , Salvatore Giuseppe , Denaro Vincenzo 
Published: June 2021

Abstract
Purpose The aim of this article is to illustrate the recent framework necessary to standardize studies on groin pain and review the existing literature on groin pain in football.
Methods The common pathological processes underlying groin pain such as muscle, tendon or ligament strain, bone injury or fracture, sport hernia, bursitis, osteitis pubis, and hip-related diseases have been reviewed and current management options have been considered.
Results Groin pain is considered a pain in pubic or lower abdominal or adductors region which can be monolateral or bilateral. It is common in high-intensity team sports and can negatively affect an athlete's professional carrier, causing serious disruption in the performance. Despite a high prevalence of groin pain in athletes, diagnosis and management of the underlying pathological processes remain a challenge for surgeons, radiologists, and physiotherapists alike.
Conclusion A multidisciplinary approach is essential for patients with groin pain allowing prompt diagnosis and initiation of treatment thus facilitating more rapid return to play and preventing potential long-term sequelae of chronic groin pathology.
Clinical Spectrum of Ocular and Visual Dysfunction in Children with Periventricular Leukomalacia: A Need for an Interdisciplinary Approach
Authors: Ozturker Zeynep Kayaarasi , Bayar Sezin Akca , Oto Sibel , Aksoy Sibel , Akkoyun Imren , Sezer Taner 
Published: June 2021

AbstractThe study aimed to evaluate the ocular motility and visual and optic disc abnormalities in children diagnosed with periventricular leukomalacia (PVL). A retrospective analysis was performed on 51 consecutive children who had ophthalmic symptoms and were diagnosed with PVL by using magnetic resonance imaging. The patients were assessed for visual function, strabismus, cycloplegic refraction, fundus examination, and if appropriate, spectral-domain optical coherence tomography and visual field testing were applied. The primary outcome measures were the prevalence and visual and ocular motility dysfunctions. Mean age was 5.72 ± 2.6 years (range = 1–12), median birth weight was 2,740 g (range = 1,240–3,460), and median gestational age was 34 weeks (range = 28–38). In total, 21 patients (39.6%) had neurological deficit, 11 (21.5%) had intellectual disability, and 19 (37.2%) had no neurological symptom. In the spherical equivalent refractive error and cylinder power analysis, 10 patients had ≥3.0 D myopia, 15 had ≥3.0 D hyperopia, and eight had ≥2.50 D astigmatism. Thirteen (25.4%) children had a best-corrected visual acuity between 20/40 and 20/20 for Snellen card, while 9 (17.6%) had strabismic amblyopia and 6 (11.7%) had anisometropic amblyopia. Manifest strabismus was present in 35 patients (68.6%); of whom 12 had esotropia (23.5%), 16 had exotropia (31.3%) and 6 had vertical deviation (11.7%). Manifest or latent nystagmus was detected in 14 patients (27.4%). In 28 patients (54.9%), there was optic nerve abnormality. Two patients had hypoplastic disc, 14 had optic disc pallor, 7 had large cupping, and 5 had total optic atrophy. Six subjects underwent reliable visual field (VF) examinations, and all six had abnormal VFs, with inferior fields being most affected. Ocular motility disorders, optic nerve abnormalities, VF defects, and low visual acuity are common findings in this cohort of PVL patients and maybe the only presenting signs of the disease. The recognition of the visual disabilities and implementation of early rehabilitation may have a significant benefit in these children.
Current Treatment Guidelines of SARS-CoV-2 Related Multisystem Inflammatory Syndrome in Children: A Literature Review and Expert Opinion
Authors: Ghodsi Alireza , Sarabi Mehrdad , Malek Abdolreza , Khakshour Ali 
Published: June 2021

AbstractMultisystem inflammatory syndrome in children (MIS-C) is a systemic disorder that seems to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since April 2020, there have been multiple reports about children with this new condition worldwide, including Europe, Asia, Latin America, and North America. The symptoms of this syndrome mimic the clinical manifestations of Kawasaki disease; therefore, the treatment of Kawasaki disease, as well as supportive care, was the management of choice in children with MIS-C in the early days of recognizing it. It is important to precisely ascertain the risk of COVID-19 infection and its severity in children and to acknowledge the management of this syndrome, with reliable data from cohorts, trials, and experts' opinions. In the current review, we summarize the current management guidelines for MIS-C and present our own protocol to answer some clinical questions regarding MIS-C management during the COVID-19 pandemic.
Early Detection and Rescue of an Unusual Case of Pediatric Acute Liver Failure Associated with Secondary Hemophagocytic Lymphophagocytosis: Case Report from a Liver Transplant Center in India
Authors: Mittal Richa , Malhotra Smita , Jerath Nameet , Mahajan Amita , Sibal Anupam 
Published: June 2021

AbstractHemophagocytic lymphohistiocytosis (HLH) is a rare, multisystem, potentially fatal clinicopathologic syndrome. HLH presenting predominantly as pediatric acute liver failure (PALF) has been rarely reported. Early recognition is imperative to initiate life-saving treatment but is often hampered due to the rarity of this syndrome, variable clinical presentations, and nonspecific clinical and laboratory findings. In this article, we reported a case of secondary HLH (H1N1 and RSV positive) presenting as PALF from India. A previously healthy 22-month-old boy presented with fever, vomiting, and altered sensorium for 10 days. He had coagulopathy and deranged liver functions. He was evaluated for underlying etiology and managed on lines of PALF. Due to persistent bicytopenia and excessively high ferritin levels, HLH was strongly suspected though he did not fulfill all clinical criteria for the diagnosis of HLH. Presence of seizures and cerebrospinal fluid analysis was suggestive of central nervous system involvement. There was no evidence of primary HLH on genetic evaluation. Real-time polymerase chain reaction amplifications were positive for RSV and influenza A H1N1, confirming the causative triggers. After the administration of immunosuppressants and oseltamivir, the patient's symptoms improved dramatically and he recovered completely. To the best of our knowledge, this is the fourth case reported worldwide till date of successful rescue of ALF in a child associated with HLH completely without resorting to liver transplantation. Clinical vigilance is crucial for possible presence of HLH with varied initial presentations in PALF despite incomplete diagnostic criteria, with detailed etiological workup for commencing life-saving therapy in time.
Wilson Disease-Induced Acute Liver Failure (NWI = 13) Salvaged without Liver Transplant by Plasmapheresis
Authors: Mirza Nida , Bharadwaj Ravi , Malhotra Smita , Sibal Anupam 
Published: June 2021

AbstractWilson disease (WD) is a disorder of copper metabolism resulting in accumulation of copper in vital organs of the human body, predominantly in the liver and the brain. Acute liver failure in WD has a bad prognosis, especially with a score ≥11 in the revised WD prognostic index; emergency liver transplantation is considered the only life-saving option in this scenario. Here, we reported a girl patient with WD-induced liver failure and poor prognostic score who was rescued by plasmapheresis. She also manifested severe Coombs negative hemolytic anemia and acute kidney injury. This case report highlights the utility of an adjunctive modality besides liver transplantation for the management of fulminant liver failure caused by WD.
Teaching an introductory optics lab course online
Authors: Dark Marta L 
Published: June 2021

Abstract
In fall 2020, the Physics Department was tasked with coming up for a plan for optics, our one credit lab course. Because of the continued COVID-19 pandemic, our institution planned to offer a fully online fall semester, with no students residing on campus. The college announced the plan 5 weeks prior to the start of the semester. This paper will detail how optics was taught online using a hybrid format of delivery.
Research on the influence of college students’ self-directed learning behavior based on online learning platform
Authors: Zhang Lulu , Tian Yue , Song Shibo 
Published: June 2021

Abstract
COVID-19 has made physical education almost forced to move to online, and the main way to acquire knowledge has also been transformed from offline to online. Especially for college students, as a group of external conditions supporting and having a strong sense of autonomy, online learning habits will have a lasting impact on subsequent learning production, and even become the second important knowledge acquisition way besides classroom. Therefore, it is necessary to study the use of online learning platform and self-directed learning behavior of college students. Based on TAM and UTAUT, this study supplements the perception theory and self-directed learning theory by extracting the influence factors of live platform. Based on the data analysis of smartpls and SPSS, this paper constructs the structural equation model of self-learning behavior of College Students’ online learning platform, explores the external and internal influence mechanism of self-learning behavior, and provides guidance for online learning platform practitioners and college students’ self-learning behavior.
Structure and software architecture design of an extremely low-cost quadruped robot for education
Authors: Zhang Y N , An M Q 
Published: June 2021

Abstract
Many teachers and students face with a serious problem of costs when they build quadruped robot. This paper illustrates a complete process of creating quadruped robot with consideration of extremely low-cost limitation. The creating procedure involves 3 major issues: 1. Driving force transmission structures. 2. Applying finite element analysis (FEA) method of reducing the cost of 3D printing components. 3. To utilize proper electronic chip, sensors and propose a corresponding software system architecture. In conclude, this paper offers a feasible common framework of creating low-cost robot, the hardware architecture and software architecture are suitable for beginning students to learn about robotics.
Mobile authentication scheme based on QKD and IBE
Authors: Chu Meiling , Wu Meng 
Published: June 2021

Abstract
In order to handle the safety problems in mobile communication systems, a mobile identity authentication scheme based on QKD and IBE is proposed. First, the quantum key distribution technology is introduced to handle the safety problems between the private key generator and the cloud services. Next, the IBE algorithm is introduced to encrypt IMSI which makes the scheme more flexible and more efficient. Finally, the quantum time parameter is proposed to manage users’ secret key. Comparing with the existing schemes, the proposed scheme can make full use of the advantages of the QKD and IBE. The mobile identity authentication scheme based on QKD and IBE can be more safe and more efficient.
Research on innovation input of manage strategy based on data analysis
Authors: Liu Liangcan , Gu Wenjie 
Published: June 2021

Abstract
Self-occupaied operation is a common mode of operation in Chinese management, and self-occupaied innovation can help maintaining their core competitiveness and achieving a favorable position. For the purpose of exploring the influence on innovation input, this paper uses the data of A-share listed objects in China from 2016 to 2019, and uses the method of data analysis to perceive the effect on innovation input. The results show that self-occupaied objects are less willing to innovate. Further analysis shows that income constraints strengthen the relationship between objects and relative connections innovation input. Under income constraints, self-occupaied object is better tend to reduce innovation input. This paper improves the research on the innovation and has certain reference significance to the innovation management in China.