bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industry 4.0 and business process management: state of the art and new challenges
Authors: Bazan Patricia , Estevez Elsa 
Published: October 2021

PurposeThe objective of the work is to analyze the impact of the Internet of Things (IoT) concepts and associated technologies in the framework of organizations and the management of their processes and how event orientation, as well as the structure of said business processes, can play an important role in this new organizational model. The main contribution of this work is to present a conceptualization of the research, identify approaches and challenges that require further study, and as a result, a proposal for future research.Design/methodology/approachThe methodology comprises a qualitative analysis using secondary data. The approach relies on searches of scientific papers conducted in well-known databases, identifying research work around the IoT and Industry 4.0 applied to business process management. Based on the identified papers, the authors selected the most relevant and the latest publications, and categorized their contributions and findings based on open and selective coding. In total, the analysis is based on 95 papers that were selected and analyzed in depth.FindingsThe results of this research allow analyzing and ordering the existing contributions around Industry 4.0 and its impact on current organizations. The proposed conceptualization was derived from the analysis of the state of the research and identifies four categories: (1) improvements caused by Industry 4.0 and its impact on inter-organizational relations, (2) new architectural models and infrastructure of remote resources, their movement from the cloud to the edge and its effect on business processes, (3) context-aware concepts brought to business process management (BPM) linked to unstructured business processes and (4) complex event processing as a possible means for business processes sensitive to IoT signals.Practical implicationsThe construction of current software ecosystems is strongly affected by the variety of information sources that feed them, as well as their volume. In addition, business processes represent organizations internally and are challenged to transcend the limits of companies due to the mentioned changes in software ecosystems. Industry 4.0 in conjunction with BPM re-defines the business process management paradigm and leads them to acquire the dynamism and sensitivity to the context that they usually did not have, as well as force them to move toward distributed platforms.Originality/valueThis paper assesses the state of the art in Industry 4.0 and business process management. The area can be defined as the intersection of two bigger areas highly relevant for organizations; on the one hand, the management and execution of business processes; and on the other hand, new conceptual, technological and methodological challenges to information systems that have to become more sensitive to event processing and also have to consume a large volume of data permanently and ubiquitously.
Institutional pressure, firm's green resources and green product innovation: evidence from Taiwan's electrical and electronics sector
Authors: Huang Yi-Chun , Chen Chih-Ta 
Published: October 2021

PurposeIntegrating economic and green initiatives into firm strategies is a challenge for firms in various industries. The study aims to incorporate multiple views, i.e. green innovation theory (GIT), the green institutional perspective (GIP) and the natural-resource-based view (NRBV), to develop a comprehensive model to explore why and how firms implement green product innovation (GPI).Design/methodology/approachThe study explores the relationships among institutional pressure, the firm's green resources and GPI. The research also distinguishes two different types of GPI: exploratory GPI and exploitative GPI. A total of 270 valid questionnaires were collected from electrical and electronics manufacturers in Taiwan. The authors employed structural equation modeling (SEM) using analysis of moment structures (AMOS) 23.0 to test the hypotheses.FindingsThe results show that institutional pressure has a significant positive correlation with the firm's green resources. Furthermore, institutional pressure has a significantly positive influence on exploratory GPI and exploitative GPI, respectively. The firm's green resources also have a significantly positive effect on both exploratory GPI and exploitative GPI. In addition, institutional pressures have significantly positive indirect effect on both exploratory GPI and exploitative GPI.Research limitations/implicationsEconomic benefits and environmental sustainability are the most pressing issues faced by the electrical and electronics industry today. The study's investigation covers Taiwanese electrical and electronics manufacturers only, so the test of the research model has limited generalizability. The authors suggest that to expand the generalizability of the findings, future research should examine this model in the context of other regions such as Southeast Asia, Africa, South America, etc.Practical implicationsThe study has many interesting implications for both practitioners and policymakers. The authors' findings suggest that while Taiwanese electrical and electronics manufacturers face significant pressure from customers, competitors and regulation requirements (e.g. waste electrical and electronic equipment [WEEE], restriction of hazardous substances [RoHS] and energy using product [EuP] directives), firms in that sector should efficiently and effectively deploy their green resources and then perform proper GPI (e.g. exploratory GPI or exploitative GPI). These results also serve as a reminder to policymakers that balancing coercive (command-and-control) mechanisms with incentives and voluntary mechanisms is the best means by which to develop motivational and effective GPI policies.Originality/valueFirst and foremost, the paper divides GPI into exploratory GPI and exploitative GPI. Furthermore, the research incorporates two important schools of thought, i.e. the GIP and NRBV, thus providing a more holistic view by which to explore why and how companies adopt GPI.
Localizing the Sustainable Development Goals: a managerial perspective
Authors: Guarini Enrico , Mori Elisa , Zuffada Elena 
Published: October 2021

PurposeThis article investigates how Sustainable Development Goals (SDGs) can be integrated into the strategic planning and management processes of local governments (LGs). It draws from the classic strategic planning and control framework developed in management studies and elaborates some propositions for adapting, implementing and monitoring the SDGs at the city level.Design/methodology/approachAs a first step in the assessment of the ways the principles of sustainable development can be integrated into LG management, this research scrutinizes the incorporation of sustainability goals in the strategic plans of all medium-to-large capital cities of provinces in Italy, a context in which there has been a National Strategy for Sustainable Development (NSSD) since 2016.FindingsThe focus on SDGs at the LG level in Italy is in its initial stage, and few capital cities have started to integrate sustainable development concerns into their comprehensive strategic plans. SDGs are used mainly as a reference framework in the strategic plans to demonstrate the contribution of LG strategies to global concerns on sustainable development.Practical implicationsThe paper offers insights for political leaders and public managers to rethink their strategic management systems, including the continuous process of evaluating and updating of strategic plans, in accordance with the multidimensional perspective of sustainability. To this end, the study has identified possible patterns of actions that public managers elsewhere will find useful.Originality/valueThe managerial approach behind the proposed conceptual framework might contribute to effectively localize the SDGs in multilevel government settings and to integrate the concept of sustainability as a guiding principle into organizational routines.
Toward a typology of weak-signal early alert systems: functional early warning systems in the post-COVID age
Authors: Černý Jan , Potančok Martin , Castro Hernandez Elias 
Published: October 2021

PurposeThe study aims to expand on the concept of an early warning system (EWS) by introducing weak-signal detection, human-in-the-loop (HIL) verification and response tuning as integral parts of an EWS's design.Design/methodology/approachThe authors bibliographically highlight the evolution of EWS over the last 30+ years, discuss instances of EWSs in various types of organizations and industries and highlight limitations of current systems.FindingsProposed system to be used in the transforming of weak signals to early warnings and associated weak/strong responses.Originality/valueThe authors contribute to existing literature by presenting (1) novel approaches to dealing with some of the well-known issues associated with contemporary EWS and (2) an event-agnostic heuristic for dealing with weak signals.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/OIR-11-2020-0513.
Function of a multimodal signal: A multiple hypothesis test using a robot frog
Authors: Caldart Vinícius Matheus , dos Santos Mauricio Beux , Machado Glauco 
Published: October 2021

Abstract

Multimodal communication may evolve because different signals may convey information about the signaller (content‐based selection), increase efficacy of signal processing or transmission through the environment (efficacy‐based selection), or modify the production of a signal or the receiver's response to it (inter‐signal interaction selection).

To understand the function of a multimodal signal (aggressive calls + toe flags) emitted by males of the frog Crossodactylus schmidti during territorial contests, we tested two hypotheses related to content‐based selection (quality and redundant signal), one related to efficacy‐based selection (efficacy backup), and one related to inter‐signal interaction selection (context). For each hypothesis we derived unique predictions based on the biology of the study species.

In a natural setting, we exposed resident males to a robot frog simulating aggressive calls (acoustic stimulus) and toe flags (visual stimulus), combined and in isolation, and measured quality‐related traits from males and local levels of background noise and light intensity.

Our results provide support to the context hypothesis, as toe flags (the context signal) are insufficient to elicit a receiver's response on their own. However, when toe flags are emitted together with aggressive calls, they evoke in the receiver qualitatively and quantitatively different responses from that evoked by aggressive calls alone. In contrast, we found no evidence that toe flags and aggressive calls provide complementary or redundant information about male quality, which are key predictions of the quality and redundant signal hypotheses respectively. Finally, the multimodal signal did not increase the receiver's response across natural gradients of light and background noise, a key prediction of the efficacy backup hypothesis.

Toe flags accompanying aggressive calls seem to provide contextual information that modify the receiver's response in territorial contests. We suggest this contextual information is increased motivation to escalate the contest, and discuss the benefits to the signallers and receivers of adding a contextual signal to the aggressive display. Examples of context‐dependent multimodal signals are rare in the literature, probably because most studies focus on single hypotheses assuming content‐ or efficacy‐based selection. Our study highlights the importance of considering multiple selective pressures when testing multimodal signal function.
Metabolic engineering of Saccharomyces cerevisiae for hydroxytyrosol overproduction directly from glucose
Authors: Bisquert Ricardo , Planells‐Cárcel Andrés , Valera‐García Elena , Guillamón José Manuel , Muñiz‐Calvo Sara 
Published: October 2021

SummaryHydroxytyrosol (HT) is one of the most powerful dietary antioxidants with numerous applications in different areas, including cosmetics, nutraceuticals and food. In the present work, heterologous hydroxylase complex HpaBC from Escherichia coli was integrated into the Saccharomyces cerevisiae genome in multiple copies. HT productivity was increased by redirecting the metabolic flux towards tyrosol synthesis to avoid exogenous tyrosol or tyrosine supplementation. After evaluating the potential of our selected strain as an HT producer from glucose, we adjusted the medium composition for HT production. The combination of the selected modifications in our engineered strain, combined with culture conditions optimization, resulted in a titre of approximately 375 mg l−1 of HT obtained from shake‐flask fermentation using a minimal synthetic‐defined medium with 160 g l−1 glucose as the sole carbon source. To the best of our knowledge, this is the highest HT concentration produced by an engineered S. cerevisiae strain.
Impact of tumor size and location on lung dose difference between stereotactic body radiation therapy techniques for non‐small cell lung cancer
Authors: Jang Seong Soon , Shin Yohan , Park Suk Young , Huh Gil Ja , Yang Young Jun 
Published: October 2021

AbstractBackgroundTo evaluate the lung dose differences between three‐dimensional conformal radiotherapy (3D‐CRT) and intensity‐modulated radiation therapy (IMRT) techniques for lung stereotactic body radiation therapy (SBRT) and the correlations with tumor characteristics, such as size and location.MethodsDosimetric comparisons between the two SBRT techniques in high‐ and low‐ to intermediate‐dose regions were retrospectively performed using four planning indices and lung‐dose parameters in 31 lung tumors. The magnitude of differences in these parameters was analyzed with relation to the planning target volume (PTV) and location‐related parameters.ResultsThe absolute differences between the two techniques in lung‐dose parameters were small in both ipsilateral and bilateral lungs. The dosimetric differences were mainly correlated with the PTV rather than location‐related parameters, with positive and negative correlations with the high‐dose and intermediate‐dose parameters, respectively. The distances from the ipsilateral lung centroid to the PTV center were not correlated with the differences in any of the lung‐dose parameters. Additionally, the negative correlations with the MLD and V20 differences disappeared after applying a more rapid dose fall‐off in the IMRT plans for tumors with small PTVs of ≤15 cc.ConclusionsLung dose differences between the 3D‐CRT and IMRT techniques for lung SBRT were mainly correlated with the PTV rather than location‐related parameters. Together with the dosimetric benefit in high‐dose lung regions of IMRT for larger tumors, the relative increases in the MLD and V20 for small‐sized tumors could be reduced by applying a more rapid dose fall‐off outside the PTV.
The risk of dementia in patients using psychotropic drugs: Antidepressants, mood stabilizers or antipsychotics
Authors: Tournier Marie , Pambrun Elodie , Maumus‐Robert Sandy , Pariente Antoine , Verdoux Hélène 
Published: October 2021

AbstractObjectiveThe risk of dementia associated with the use of psychotropic drugs is not fully understood. A nested case‐control study was carried out to assess the risk of dementia broadly defined or Alzheimer's disease associated with antidepressants, mood stabilizers or antipsychotics.MethodsA cohort was formed from healthcare claim databases including all patients aged 50 and over with a first dispensing of the psychotropic drugs concerned between 2006 and 2017. Patients who developed dementia over the study period were considered as cases. The association between drug exposure prior to a five‐year lag time and diagnosis of dementia was assessed by conditional logistic regression models.ResultsNo association was found between dementia, either broadly defined or Alzheimer disease, and antidepressant or mood stabilizers. Findings were conflicting with regard to antipsychotics. First‐ and second‐generation antipsychotics (FGA and SGA) were not associated with Alzheimer disease. SGA treatments of more than 3 months were associated with a higher risk of dementia broadly defined than no use of antipsychotics (Odds ratio [OR] 2.00; 95%CI 1.06–3.79; p = 0.03). In a sensitivity analysis using a lag time of 3 years, ever use of SGA and SGA treatments of more than 3 months were associated with a higher risk of dementia broadly defined than no use of antipsychotics (OR 1.71; 1.10–2.67; p = 0.02 and OR 1.84; 1.03–3.32; p = 0.04, respectively).ConclusionThe association between antipsychotics and dementia should be further investigated to establish patients, specific drugs, and patterns of treatment at risk. Prescribers should remain cautious when prescribing them.
Trap type affects dung beetle taxonomic and functional diversity in Bornean tropical forests
Authors: Ong Xin Rui , Hemprich‐Bennett David , Gray Claudia L. , Kemp Victoria , Chung Arthur Y. C. , Slade Eleanor M. 
Published: October 2021

AbstractBaited pitfall traps (BPTs) and flight intercept traps (FITs) are the most common methods employed for sampling dung beetle communities. These methods vary in their efficacy and are affected by factors such as the bait types used and the dispersal abilities of different dung beetle species. We present the first quantitative comparison of the community composition, taxonomic and functional diversity of dung beetles caught in human dung BPTs and FITs in Bornean tropical forests. Functional diversity metrics were calculated based on the three functional traits of nesting method, body length, and diel activity. We show that BPTs and FITs captured complementary communities with different functional traits, and that BPTs captured more functionally diverse communities. We therefore recommend using a combination of both BPTs and FITs for studies assessing the composition of dung beetles across habitat types. Our results also highlight that it is important to consider how trap type affects the trait composition of communities when relating dung beetle communities and functional traits to ecological functioning. We suggest modifications to FITs based on the design of harp traps to increase their effectiveness in capturing larger‐bodied beetles.
The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID‐19 vaccine
Authors: Labella Marina , Céspedes Jose Antonio , Doña Inmaculada , Shamji Mohamed H. , Agache Ioana , Mayorga Cristobalina , Torres Maria José 
Published: October 2021

AbstractBackgroundmRNA‐based COVID‐19 vaccines have been reported to induce hypersensitivity reactions (HSR) in a small number of individuals. We aimed to evaluate the real‐world incidence of the BNT162b2 mRNA COVID‐19 vaccine HSR and to determine the value of the basophil activation test (BAT) in the allergological workup of patients reporting these reactions.MethodsWe prospectively enrolled patients with a clinical history indicative of HSR to the BNT162b2 mRNA COVID‐19 vaccine. The allergological workup included skin testing (STs) and BAT with polyethylene glycol (PEG) and the vaccine. In those with negative allergy assessments, the administration of the second dose of the BNT162b2 mRNA COVID‐19 vaccine was offered.ResultsSeventeen adults were included. Eleven cases (64.7%) tested negative in the allergological workup and tolerated the re‐administration of the second dose of the vaccine and considered non‐allergic. Six cases (35.3%) were considered allergic and classified into three groups: 2 subjects displayed positive STs and/or BAT to PEG (Group A), two individuals displayed positive BAT to the vaccine (Group B), and in 2 patients with moderate or severe reactions, the culprit was not identified, tested negative to STs and BAT to both PEG and vaccine (Group C). We further evaluated the value of BAT when the results were positive to the vaccine and negative to PEG by performing BAT in controls groups, finding positive BAT results in 50% of controls, all of them recovered from COVID‐19 infection. In contrast, BAT was negative in patients who had not suffered from COVID‐19 disease.ConclusionsBAT can be used as a potential diagnostic tool for confirming allergy to PEG excipient but not to the vaccine as a positive result in BAT may indicate a past COVID‐19 infection instead of an allergy.
Prevalence of congenital cryptorchidism in Estonia
Authors: Kübarsepp Viljo , Varik Karin , Varendi Heili , Antson Anne , Veinla Maie , Nellis Georgi , Merila Mirjam , Salundi Urve , Astover Valve , Punab Margus 
Published: October 2021

AbstractBackgroundCryptorchidism is one of the most common urogenital malformations. Cryptorchidism prevalence varies greatly in different countries and populations. The aim of the current study was to determine and analyse cryptorchidism prevalence in Estonia.Materials and methodsDuring 2012–2015, all consecutively born 5014 boys at Tartu University Hospital were examined for cryptorchidism. All the subjects with cryptorchidism were followed up for at least 6 months to assess spontaneous testicular descent.ResultsNote that 2.1% cases had one or both testicles undescended at birth, 1.6% cases at expected date of birth, 1% cases at 3 months of age, and 0.8% cases at the age of 6 months had cryptorchidism. Cryptorchidism prevalence at birth was higher in preterm boys (11.9%), boys of low birth weight (16.7%) and boys small for gestational age (14%) but was lower in full‐term newborn boys (1.1%). During follow‐up, testes descended spontaneously in 61.6% of boys, more commonly in prematurely born boys (92%) and boys with low gestational weight (93%) as compared to full‐term cryptorchid boys (29.2%) and cryptorchid boys with normal birth weight (34%). At the age of 6 months, cryptorchidism prevalence was equalized in preterm boys (0.9%) and boys with low birth weight (1%) as compared to full‐term boys (0.7%) and boys with normal birth weight (0.7%). Boys SGA required surgical intervention more commonly than boys with normal birth weight. Ethnically, cryptorchidism prevalence at birth was similar among Estonians and non‐Estonians.ConclusionOur data revealed that cryptorchidism prevalence, especially in full‐term boys, is lower in Estonia than reported in the other Nordic‐Baltic countries and worldwide.
Editorial: lymphocytic gastritis and its relationships with other gastrointestinal disorders—authors’ reply
Authors: Genta Robert M. , Sonnenberg Amnon 
Published: October 2021

LINKED CONTENTThis article is linked to Genta et al and Annibale & Falangone papers. To view these articles, visit https://doi.org/10.1111/apt.16621 and https://doi.org/10.1111/apt.16653
Editorial: the never‐ending story—Helicobacter pylori and peptic ulcer disease. Authors' reply
Authors: Jiang Fang , Guo Chuan‐Guo , Leung Wai K. 
Published: October 2021

LINKED CONTENTThis article is linked to Jiang et al and Sugano & Howden papers. To view these articles, visit https://doi.org/10.1111/apt.16604 and https://doi.org/10.1111/apt.16617