bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of 'Coaching' Model in 'Pumping-HR' Based Human Resource Development Model
Authors: Ramly Amir Tengku , Irawan Andi , Warcito Warcito 
Published: October 2021

<p><em>Coaching is a partner of development in which a coach supports a learner in achieving a specific personal or professional goal by training and counselling. The pumping HR Model is one of the HR development models based on the iceberg theory, which is divided into the areas of the unconscious (unconscious region), pre-conscious (pre-conscious region) and conscious (conscious region). The pumping HR Model places the unconscious as a function of the heart, the pre-conscious as a function of the brain and the conscious as a sensory function of human resources (HR). In practice, Pumping HR Model touches on 3 basic components of human resource development, namely character development, competency development and behaviour development. This research goal is the purpose of this study is to prove that the Pumping HR model can be used as a model in the coaching process. The method used is </em><em>qualitative descriptive &amp; Integrating theory. Research data were obtained through a Focus Group Discussion (FGD) and post-workshop questionnaire. The results of this research: Pumping HRM Coach is unique and can be one of the human resource development models with a coaching approach.</em><em></em></p>
Study of the effectiveness of osteopathic correction in the complex treatment of patients with operated primary open-angle glaucoma
Authors: Zubkov O. V. , Smirnova E. A. , Kramar V. V. , Kurbatov O. I. 
Published: October 2021

Introduction. Glaucoma is a chronic eye disease characterized by a constant or periodic increase in intraocular pressure, a decrease of visual fields and visual acuity, and by a special form of optic nerve atrophy with excavation in the disc area. The reflection of this slowly fl owing atrophy is a disturbance in the visual field and a complete irreversible loss of visual function. The prevalence of the disease increases with increasing age. The main methods of treatment are medical and surgical. Non-penetrating operations are recognized as the safest methods of surgical treatment of glaucoma. The most common complications of such operations include: detachment of the choroid, small anterior chamber syndrome, hyphema, cicatricial changes in the filtration cushion. Based on the analysis of literature data, it can be assumed that the inclusion of osteopathic correction in the complex therapy of patients with operated glaucoma can increase the effectiveness of therapy.The aim of the research was to study the clinical efficacy of osteopathic correction in the complex treatment of patients operated on primary open-angle glaucoma.Materials and methods. The study involved 20 patients (20 eyes) aged 70 to 75 years with developed and advanced stages of primary open-angle glaucoma, who underwent surgical treatment. The main (10 people) and control (10 people) groups were formed by simple randomization. Participants in the main group received standard medical therapy and osteopathic correction, while participants in the control group received only medical therapy. Changes in the following clinical parameters were evaluated: visual acuity, visual fi eld, intraocular pressure, thickness of the retinal nerve fiber layer, and severity of pain syndrome. Indicators were recorded at the beginning of the study (2 weeks after surgery) and at the end of the study (2–3 months after surgery).Results. Patients receiving osteopathic correction as part of the complex therapy after surgery of primary openangle glaucoma are characterized by a statistically significant (p<0,05) decrease in the severity of pain syndrome, an increase in the magnitude of the visual field and of the thickness of the retinal nerve fiber layer.Conclusion. The obtained results suggest the effectiveness of the inclusion of osteopathic correction in the complex treatment of patients with operated on primary open-angle glaucoma. It is recommended to continue the study with a larger sample size.
META ANALISIS PENGARUH MODEL PEMBELAJARAN KOOPERATIF PADA MATA PELAJARAN FISIKA TERHADAP HASIL BELAJAR SISWA
Authors: Erpan Alhadi , Nanda Fadilah Fajria , Augustini Millanie Chintya , Desnita Desnita 
Published: October 2021

ABSTRAK Penelitian ini adalah penelitian meta-analisis yang bertujuan merangkup hasil penelitian tentang pengaruh model pembelajran kooperatif terhadap hasil belajar siswa sehingga dapat diketahui : besar dari effect size (ES) rata-rata, tipe model pembelajaran koperatif yang memiliki effect size paling besar dan pada jenjang pendidikan dan materi apa tipe model pembelajaran kooperatif lebih berpengaruh terhadap hasil belajar siswa. Penelitian ini dilakukan dengan mengumpulkan 20 hasil penelitian berupa artikel jurnal. Hasil dari penelitian menunjukkan bahwa ES rata-rata sebesar 0,98 yang berarti berpengaruh tinggi. Tipe model pembelajaran kooperatif yang paling berpengaruh adalah tipe Team Games Tournament (TGT) dengan rata-rata ES sebesar 1,26. Model pembelajaran kooperatif lebih berpengaruh pada jenjang pendidikan SMA dengan rata-rata ES sebesar 1,06 serta pada materi suhu dan kalor dengan ES sebesar 1,46 yang masuk kategori sangat tinggi.ABSTRACT This research is a Meta-Analysis research which aims to summarize the result of research on the effect of cooperative learning models on student learning outcomes so that it can be seen : the size of the averange effect size (ES), the type of cooperative learning model that has the greatest effect size and at the level of education. And what type of material the cooperative learning model has more influence on student learning outcomes. This research was conducted by collecting 20 research results in the form of journal articles. The results of the study indicate that the ES on average is 0.98 which means that it has a high effect. The type of cooperative learning model that has the most influence is the type of Team Games Tournament (TGT) with an average ES of 1.26. the cooperative learning model has more influence on the high school education level with an average ES of 1.06 and on temperature and heat material with an ES of 1.46 which is in the very hight category
STUDI PERBEDAAN PERSIAPAN BAHAN BAKU SURIMI TERHADAP KUALITAS SENSORIK DAN KIMIA SOSIS IKAN BANDENG (Chanos chanos Forsskal)
Authors: Endang Wa , Patadjai Andi Besse , Isamu Kobajashi Togo 
Published: October 2021

AbstrakPenelitian ini bertujuan untuk menentukan pengaruh persiapan bahan baku surimi yang berbeda pada kualitas sensoris dan kimia sosis ikan bandeng (Chanos chanos Forsskal). Pada penelitian ini terdapat tiga metode persiapan bahan baku yang digunakan sebagai bahan baku sosis ikan yaitu 100% surimi sebagai perlakuan S1; 50% surimi : 50% daging ikan cincang sebagai perlakuan S2; dan 100% daging ikan cincang sebagai perlakuan S3. Kualitas bahan baku ditentukan dengan uji lipat dan uji gigit, sedangkan untuk sosis ikan dilakukan analisis sensorik dan analisis proksimat. Data yang dikumpulkan dianalisis secara deskriptif. Berdasarkan hasil penelitian yang diperoleh menunjukan bahwa perlakuan 100% surimi (S1) diperoleh hasil uji sensorik aroma 5,4, odor 6,7, warna 5,25, berongga 4,9, shiness 5,4, kekenyalan 5,5, hardness 2,4, Juiceness 5,6, umami 6. Hasil analisis kimia dari perlakuan (S3) berdasarkan berat kering diperoleh hasil kadar air, abu, lemak, protein berturut-turut yakni 58,96, 6,22%, 19,12%, 48,6%.Kata Kunci : Bahan baku, Surimi, Sensorik, Sosis
PENGARUH PENAMBAHAN DAGING GURITA (Octopus cyanea) TERHADAP NILAI ORGANOLEPTIK DAN KANDUNGAN PROKSIMAT STIK GURITA
Authors: Yani Yani , Ibrahim Moh Nuh , Suwarjoyowirayatno Suwarjoyowirayatno 
Published: October 2021

AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh penambahan daging gurita terhadap nilai organoleptik, proksimat stik gurita. Metode penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari tiga perlakuan yaitu P1 (Daging gurita 35%), P2 (Daging gurita 45%), P3 (Daging gurita 55%). Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (p>0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncam Multiple Range Test) pada taraf nyata 95%. Kandungan protein dan lemak diuji menggunakan metode AOAC dan kandungan karbohidrat di uji menggunakan metode nelson-smogiy. Hasil uji kandungan kadar lemak dan karbohidrat tertinggi terdapat pada perlakuan P1 dengan nilai 34,27% dan 7,81% dan Kandungan protein tertinggi pada perlakuan P3 dengan nilai 32,04%. Hasil penelitian ini menunjukan bahwa terdapat pengaruh nyata terhadap kandungan lemak dan karbohidrat serta tidak terdapat pengaruh nyata pada kandungan air dan protein pada stik gurita. Kata kunci: Daging gurita (Octopus cyanea), stik gurita, kandungan proksimat, uji organoleptik AbstractThis study aims to determine the effect Octopus cyanea addition on organoleptic values and proximate content of octopus sticks. This research method used a completely randomized design (CRD) consisting of three treatments P1 (35% octopus meat), P2 (45% octopus meat), P3 (55% octopus meat). Observation data were analyzed using ANOVA (Analysis of Variance) at the level 95%, if there were significant differences (p>0,05) then further testing was carried out with DMRT (Duncan Multiple Range Test) at 95%. The content of protein and fat was tested by the AOAC method and the carbohydrate content was tested by the nelson-smogiy method. The highest test results for the content of fat and carbohydrate were found in treatment P1 with a value of 34.27% and 7.81% and the highest protein content found in treatment P3 with a value of 32.04%. The results of this study indicated that there is a real effect on the content of fat and carbohydrates and there is no significant effect on the water content and protein of octopus sticks. Key words: Octopus cyanea, octopus stick, proximate content, organoleptic value
PENGARUH PERBANDINGAN KOSENTRASI GLUKOSA DAN SUKROSA TERHADAP KUALITAS SENSORI DAN KIMIA PERMEN JELLY RUMPUT LAUT (Eucheuma cottonii)
Authors: Jaldin Arifi , Haslianti Haslianti , Asyik Nur 
Published: October 2021

The Effect of Comparison of Glucose and Sucrose Concentration on the Sensory and Chemical Quality of Jelly Candy (Eucheuma cottonii) ABSTRACT The aims of this study were to determine the effect of different concentrations of glucose and sucrose on the sensory and chemical quality of seaweed jelly candy (Eucehuma cottonii). The study used a Completely Randomized Design (CRD) consisting of 4 treatments, namely : P1 (glucose : sucrose = 45% : 0%), P2 (glucose : sucrose = 0% : 45%, P3 (glucose : sucrose = 30% : 15%), P4 (glucose : sucrose = 15% : 30%) with time three replications. Data from observations were analyzed using ANOVA (Analysis of Variance) at a level of 95%, if there is a real difference (P> 0.05) then a further test was performed with a DMRT (Duncan Multiple Range Test) tests at a 95% significance level. The results obtained show a real effect on sensory values which include color, texture, and taste but no significant effect on the scent. The best results for sensory assessment were found in the P4 treatment which has a taste value of 4.5, texture of 4.2, the scent of 4.0, and a taste of 4.2. The results showed the water content between 22.83%-17.01%, ash content of 0.11%-0.18%. and protein content of 3.75%-5.77%. Keywords: chemistry, glucose, jelly candy, seaweed (Eucheuma cottonii), sensory, and sucroseABSTRAKTujuan penelitian ini adalah untuk mengetahui pengaruh perbedaan kosentrasi glukosa dan sukrosa terhadap kualitas sensori dan kimia permen jelly rumput laut (E. cottonii). Penelitian menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan yaitu : P1 (glukosa : sukrosa = 45% : 0%), P2 (glukosa : sukrosa = 0% : 45 %), P3 (glukosa : sukrosa = 30% : 15%), P4 (glukosa : sukrosa = 15% : 30%) dan ulangan sebanyak tiga kali. Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (P>0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncan Multiple Range Test) pada taraf nyata 95%. Hasil penelitian yang diperoleh menunjukkan pengaruh nyata terhadap nilai sensori yang meliputi warna, tekstur, dan rasa namun diperoleh pengaruh tidak nyata pada aroma. Hasil terbaik untuk penilaian sensori terdapat pada perlakuan P4 yaitu memiliki nilai rasa 4,5, tekstur 4,2, aroma 4,0, dan rasa 4,2. Hasil penelitian menunjukkan kadar air antara 22,83%-17,01%, kadar abu 0,11%-0,18%. dan kadar protein 3,75%-5,77%..Kata kunci: glukosa, kimia, permen jelly, rumput laut (Eucheuma cottonii), sensori, sukrosa
KARAKTERISTIK KIMIA TEPUNG SILASE LIMBAH IKAN TUNA (Thunnus sp.) DENGAN PENAMBAHAN TEPUNG JAGUNG
Authors: Safitra Safitra , Asnani Asnani , Rejeki Sri 
Published: October 2021

Chemical characteristics of Silage Flour from Tuna Fish Waste (Thunnus sp.) with cornflour additionABSTRACT The purpose of this study was to determine the chemical characteristics and the effect of the addition of cornflour to tuna waste silage flour. This study used a Completely Randomized Design (CRD) consisting of four treatments, namely TS1 (5% addition to corn flour), TS2 (10% adding corn flour), TS3 (15% adding corn flour), TS4 (20% adding cornflour) ) and repeat three times. Data from observations were analyzed using ANOVA (Analysis of Variance) at a level of 95%, if there is a real difference (P> 0.05) then a further test was performed with a DMRT (Duncan Multiple Range Test) tests at a 95% level. The results showed that the effect of adding cornflour to fish waste silage flour had a significant effect on the chemical content test value. The results of the chemical test of the silage flour show water content between 10.4% -8.4%, ash content of 24.2% -7.9%, protein content of 47.5% -43.3%, and fat content of 4.6 % -2.1%. Keywords: Silage flour, tuna waste (Thunnus sp.), Cornflour and proximate composition.ABSTRAKTujuan penelitian ini adalah untuk mengetahui karakteristik kimia dan pengaruh penambahan tepung jagung pada tepung silase limbah ikan tuna. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari empat perlakuan yaitu perlakuan TS1 (5% penambahan tepung Jagung), TS2 (10% penambahan tepung jagung), TS3 (15% penambahan tepung jagung), TS4 (20% penambahan tepung jagung) dan ulangan sebanyak tiga kali. Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (P>0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncan Multiple Range Test) pada taraf nyata 95%. Hasil penelitian yang diperoleh menunjukkan bahwa pengaruh penambahan tepung jagung pada tepung silase limbah ikan memberikan pengaruh nyata terhadap nilai uji kandungan kimia. Hasil uji kandungan kimia tepung silase menunjukkan kadar air antara 10,4%-8,4%, kadar abu 24,2%-7,9%, kadar protein 47,5%-43,3%, dan kadar lemak 4,6%-2,1%.Kata kunci: Tepung silase, limbah ikan tuna (Thunnus sp.), tepung jagung serta komposisi proksimat
PENGARUH PENAMBAHAN GARAM YANG BERBEDA TERHADAP TINGKAT KESEGARAN IKAN CAKALANG (Katsuwonus pelamis)
Authors: Mitra Lia , Haslianti Haslianti , Suwarjoyowirayatno Suwarjoyowirayatno 
Published: October 2021

Effect of Different Additions of Salt on Freshness of Skipjack Fish (Katsuwonus pelamis) ABSTRACT The aim of this study was to determine organoleptic changes, water content, pH, TPC of skipjack tuna with different handling methods. This study used a Randomized Block Design (RBD) with 2 treatment factors, the first treatment factor of adding salt consisting of 2 levels, 10% salt (P0) and 15% salt (P1). The second treatment factor is storage time which consists of 3 levels, H1 (1 day), H2 (2 days), and H3 (3 days). Organoleptic tests include gills, mucus, eyes, texture and aroma. while chemical tests include water content, pH and TPC. The results of the organoleptic test on the best treatment gill parameter P1H1 with a value of 8,16, mucus with a value of 8.16, eyes with a value of 8,12, aroma with a value of 8,04 and the best treatment texture at P0H1 value of 8,04. While the chemical test of water content was in the P1H1 treatment with a value of 71,74%, the lowest treatment in the P0H1 with a value of 71,16%. The highest value of pH parameters in the P1H1 treatment with a value of 5,84%, the lowest treatment at P0H1 with a value of 5,64%. The highest value of TPC parameters in the P0H1 with a value of 4.67 × 105 CFU/g and the lowest value in the P1H1 with a value of 4.29 × 105 CFU/g. Keywords: addition of salt, the freshness of fish, organoleptic test, skipjack fish, TPC.ABSTRAKTujuan penelitian ini adalah untuk mengetahui perubahan organoleptik, kadar air, pH, TPC ikan cakalang dengan metode penanganan yang berbeda. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 2 faktor perlakuan yaitu faktor perlakuan pertama penambahan garam yang terdiri dari 2 taraf yaitu penambahan garam 10% (P0) dan penambahan garam 15 % (P1). Faktor perlakuan kedua adalah waktu penyimpanan yang terdiri dari 3 taraf yaitu H1 (1 hari), H2 (2 hari), dan H3 (3 hari). Uji organoleptik meliputi insang, lendir, mata, tekstur dan aroma. sedangkan uji kimia meliputi kadar air, pH dan TPC. Hasil penelitian uji organoleptik pada pameter insang perlakuan terbaik P1H1 dengan nilai sebesar 8,16, lendir dengan nilai sebesar 8,16, mata dengan nilai sebesar 8,12,aroma dengan nilai sebesar 8,04 dan tekstur dperlakuan terbaik pada P0H1 nilai sebesar 8,04. Uji kimia nilai tertinggi uji kimia yaitu kadar air terdapat pada perlakuan P1H1 dengan nilai sebesar 71,74%, perlakuan terendah pada perlakuan P0H1 dengan nilai sebesar 71,16%. Parameter pH nilai tertinggi pada perlakuan P1H1 dengan nilai sebesar 5,84%, perlakuan terendah pada P0H1 dengan nilai sebesar 5,64%. Parameter TPC nilai tertinggi pada perlakuan P0H1 dengan nilai sebesar 4,67 × 105 CFU/g dan nilai terendah pada perlakuan P1H1 dengan nilai sebesar 4,29 × 105 CFU/g.Kata kunci: Ikan cakalang, kesegaran ikan, penambahan garam, TPC, uji organoleptik.
UJI MUTU DAN KEAMANAN PANGAN SATE POKEA (Batissa violacea var. celebensis, von Martens 1897) YANG DI PASARKAN DI OBJEK WISATA PANTAI TORONIPA KABUPATEN KONAWE SULAWESI TENGGARA
Authors: Arpin Iin Caroline , Isamu Kobajashi Togo , Suwarjoyowirayatno Suwarjoyowirayatno 
Published: October 2021

ABSTRACT Pokea is endemic animals originating from the Southeast Sulawesi region. Pokea meat processing is generally made into satay. This study aims to determine the chemical content and heavy metal of pokea satay which is sold in the Toronipa Beach Tourism Object, Southeast Sulawesi. The research method will be conducted in the form of representative sampling from satay pokea traders accompanied by interviews related to the processing of satay pokea, measurement of water content, protein, fat, ash, Fe, and Pb content. Based on the test results, it showed that the chemical content and heavy metal of satay pokea varied. The highest water content is 43.33%, the highest ash content is 19.17%, the highest fat content is 39.36%, The highest content of water, ash, fat, protein, Fe and Pb are 43.33%, 19.17%, 39.36%, 66.04%, 6.00 ppm and <0, 01 ppm respectively. Keywords: Fe, Heavy, Satay pokea, PbABSTRAKKerang pokea adalah hewan endemik yang berasal dari daerah Sulawesi Tenggara. Pengolahan kerang pokea umumnya dibuat menjadi sate kerang. Penelitian ini bertujuan untuk mengetahui kandungan kimia dan kandungan logam berat sate kerang pokea yang dijual di daerah Objek Wisata Pantai Toronipa, Sulawesi Tenggara. Metode penelitian yang akan dilakukan berupa pengambilan sampel representatif dari pedagang sate pokea disertai wawancara terkait pengolahan sate pokea, pengukuran kadar air, protein, kadar lemak, kadar abu, kadar Fe dan Pb. Berdasarkan hasil uji, menunjukkan bahwa kandungan kimia dan logam berat sate pokea bervariasi. Kadar air tertinggi yaitu sebesar 43,33%, kadar abu tertinggi yaitu 19,17%, kadar lemak tertinggi 39,36%, kadar protein tertinggi 66,04%, kadar Fe tertinggi 6,00 ppm dan kadar Pb untuk setiap sampel < 0,01 ppm.Kata kunci: logam berat, logam Fe, logam Pb, Pantai Toronipa, sate pokea
Nicotiana spp. for the Expression and Purification of Functional IgG3 Antibodies Directed Against the Staphylococcus aureus Alpha Toxin
Authors: Opdensteinen P. , Meyer S. , Buyel J. F. 
Published: October 2021

Immunoglobulin subclass IgG1 is bound and neutralized effectively by Staphylococcus aureus protein A, allowing the bacterium to evade the host’s adaptive immune response. In contrast, the IgG3 subclass is not bound by protein A and can be used to treat S. aureus infections, including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). However, the yields of recombinant IgG3 are generally low because this subclass is prone to degradation, and recovery is hindered by the inability to use protein A as an affinity ligand for antibody purification. Here, we investigated plants (Nicotiana spp.) as an alternative to microbes and mammalian cell cultures for the production of an IgG3 antibody specific for the S. aureus alpha toxin. We targeted recombinant IgG3 to different subcellular compartments and tested different chromatography conditions to improve recovery and purification. Finally, we tested the antigen-binding capacity of the purified antibodies. The highest IgG3 levels in planta (&gt;130 mg kg−1 wet biomass) were achieved by targeting the endoplasmic reticulum or apoplast. Although the purity of IgG3 exceeded 95% following protein G chromatography, product recovery requires further improvement. Importantly, the binding affinity of the purified antibodies was in the nanomolar range and thus comparable to previous studies using murine hybridoma cells as the production system.
Case Report: Sustained Remission Due to PD-1-Inhibition in a Metastatic Melanoma Patient With Depleted B Cells
Authors: Wulfken Lena Margarethe , Becker Jürgen Christian , Hayajneh Rami , Wagner Annette Doris , Schaper-Gerhardt Katrin , Flatt Nina , Grimmelmann Imke , Gutzmer Ralf 
Published: October 2021

IntroductionCheckpoint-Inhibition (CPI) with PD-1- and PD-L1-inhibitors is a well-established therapy for advanced stage melanoma patients. CPI mainly acts via T-lymphocytes. However, recent literature suggests also a role for B cells modulating its efficacy and tolerability of CPI.Case ReportWe report a 48-year-old female patient with metastatic melanoma affecting brain, lung, skin and lymph nodes. A preexisting granulomatosis with polyangiitis was treated with rituximab over five years prior to the diagnosis of melanoma, resulting in a complete depletion of B cells both in peripheral blood as well as the tumor tissue. In the absence of the mutation of the proto-oncogene b-raf, treatment with the PD-1 inhibitor nivolumab was initiated. This therapy was well tolerated and resulted in a deep partial response, which is ongoing for 14+ months. Flow cytometric analysis of peripheral blood mononuclear cells revealed 15% IL-10 producing and 14% CD24 and CD38 double positive regulatory B cells.ConclusionThe exceptional clinical response to nivolumab monotherapy in our patient with depleted B cells sheds a new light on the relevance of B cells in the modulation of immune responses to melanoma. Obviously, B cells were not required for the efficacy of CPI in our patient. Moreover, the depletion of regulatory B cells may have improved efficacy of CPI.