bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hidden Gems
Authors: Tanenbaum Adena 
Published: May 2021

Abstract
Unlike the Hebrew maqāma from Iberia, the Hebrew maqāma from Yemen has received little attention. This article brings the reader into the world of the Yemeni Hebrew maqāma between the sixteenth and nineteenth centuries with such works as Aluʾel’s “Dispute Between the Calf and the Slaughterer,” the seemingly related “Parable of the Rooster,” “Haman’s Epistle,” al-Ḍāhirī’s Sefer ha-musar (roughly, “Book of adab”), Ḥarazi’s “Paths of Faith,” and Manṣura’s “Book of Thought.” Al-Ḍāhirī’s monumental work, for example, builds on diverse sources such as the maqāmāt of al-Hamaḏānī and al-Ḥarīrī, al-Ḥarīzī’s Taḥkemoni, and Immanuel of Rome’s Maḥberot and, like other maqāma collections, reworks many existing genres (folk tales, homilies, poems, letters, riddles, travelogues, dialogues, debates, and mystical writings). As such, it is a poignant testimony to Jewish intellectual culture in Yemen writ large.
Global Patterns of Hottest, Coldest, and Extreme Diurnal Variability on Earth
Authors: Zhao Yunxia , Norouzi Hamid , Azarderakhsh Marzi , AghaKouchak Amir 
Published: May 2021

ABSTRACTMost previous studies of extreme temperatures have primarily focused on atmospheric temperatures. Using 18 years of the latest version of the Moderate Resolution Imaging Spectroradiometer (MODIS) land surface temperature (LST) data, we globally investigate the spatial patterns of hot and cold extremes as well as diurnal temperature range (DTR). We show that the world’s highest LST of 80.8°C, observed in the Lut Desert in Iran and the Sonoran Desert in Mexico, is over 10°C above the previous global record of 70.7°C observed in 2005. The coldest place on Earth is Antarctica with the record low temperature of −110.9°C. The world’s maximum DTR of 81.8°C is observed in a desert environment in China. We see strong latitudinal patterns in hot and cold extremes as well as DTR. Biomes worldwide are faced with different levels of temperature extremes and DTR: we observe the highest zonal average maximum LST of 61.1° ± 5.3°C in the deserts and xeric shrublands; the lowest zonal average minimum LST of −66.6° ± 14.8°C in the tundra; and the highest zonal average maximum DTR of 43.5° ± 9.9°C in the montane grasslands and shrublands. This global exploration of extreme LST and DTR across different biomes sheds light on the type of extremes different ecosystems are faced with.
Shear, Stability and Mixing within the Ice-Shelf-Ocean Boundary Current
Authors: Jenkins Adrian 
Published: May 2021

AbstractWhen the inclined base of an ice shelf melts into the ocean, it induces both a statically-stable stratification and a buoyancy-forced, sheared flow along the interface. Understanding how those competing effects influence the dynamical stability of the boundary current is the key to quantifying the turbulent transfer of heat from far-field ocean to ice. The implications of the close coupling between shear, stability and mixing are explored with the aid of a one-dimensional numerical model that simulates density and current profiles perpendicular to the ice. Diffusivity and viscosity are determined using a mixing length model within the turbulent boundary layer and empirical functions of the gradient Richardson number in the stratified layer below. Starting from rest, the boundary current is initially strongly stratified and dynamically stable, slowly thickening as meltwater diffuses away from the interface. Eventually, the current enters a second phase where dynamical instability generates a relatively well-mixed, turbulent layer adjacent to the ice, while beneath the current maximum, strong stratification suppresses mixing in the region of reverse shear. Under weak buoyancy forcing the timescale for development of the initial dynamical instability can be months or longer, but background flows, which are always present in reality, provide additional current shear that greatly accelerates the process. A third phase can be reached when the ice shelf base is sufficiently steep, with dynamical instability extending beyond the boundary layer into regions of geostrophic flow, generating a marginally-stable pycnocline through which the heat flux is a simple function of ice-ocean interfacial slope.
Buen vivir and Changes in Education in Ecuador, 2006–2016
Authors: Echavarría Ricardo Restrepo , Orosz Agnes 
Published: May 2021

Education is a pillar of buen vivir, the guiding ideal of Ecuador’s 2008 Constitution. In this framework, Ecuador made significant shifts in its education system from 2006 to 2016, the decade of the Citizens’ Revolution. The key buen vivir concepts and processes that framed these shifts were considering education as a right, as a social debt, and as a driver of a more just, knowledge-intensive and clean economy. Resource allocation, general access, learning, and inclusion of structurally marginalized groups showed significant improvement in this decade, along with other key political, economic and social changes, thus making significant advances in the emancipation of society toward buen vivir, and marking elements of how and why advancing this transformation is important. La educación como derecho es un pilar del buen vivir, el ideal rector de la Constitución de Ecuador de 2008. En este marco, Ecuador realizó cambios significativos en su sistema educativo de 2006 a 2016. Los conceptos y procesos clave que enmarcaron estos cambios fueron considerar la educación como un derecho, una deuda social, y el motor de una economía más justa, intensiva en conocimiento y limpia. La asignación de recursos, el acceso general, el aprendizaje y la inclusión de grupos estructuralmente marginados tuvieron mejorías significativas, junto a otros cambios políticos, económicos y sociales claves, realizando avances significativos en la emancipación de la sociedad hacia el buen vivir, así como delineando elementos de cómo y por qué avanzar esta transformación es importante.
Analysis of frequency and severity of relapses in multiple sclerosis patients treated with cladribine tablets or placebo: The CLARITY and CLARITY Extension studies
Authors: De Stefano Nicola , Sormani Maria Pia , Giovannoni Gavin , Rammohan Kottil , Leist Thomas , Coyle Patricia K , Dangond Fernando , Keller Birgit , Alexandri Nektaria , Galazka Andrew 
Published: May 2021

Background: In the CLARITY (CLAdRIbine Tablets treating multiple sclerosis orallY) study of patients with relapsing-remitting multiple sclerosis, treatment with cladribine tablets 3.5 mg/kg (CladT) significantly reduced the annualised relapse rate (ARR) versus placebo; this effect was sustained in CLARITY Extension, without further treatment. Objective: To assess the frequency and severity of relapses in patients treated with CladT versus placebo in CLARITY over 2 years and evaluate the durability of effect in patients who received no further treatment for 2 years in CLARITY Extension. Methods: In this post hoc analysis, ARRs were calculated for qualifying and all relapses, and qualifying and all severe relapses (i.e. requiring steroid treatment or leading to hospitalisation) in patients treated with CladT ( n = 433) and placebo ( n = 437) in CLARITY, and those from the CladT group who received placebo in CLARITY Extension ( n = 98). Results: At Month 6, Year 1 and Year 2, patients receiving CladT had a significantly lower risk of qualifying or all relapses (all p < 0.0001), and qualifying or all severe relapses (all p < 0.005), compared with placebo. This effect was sustained in CLARITY Extension without further treatment. Conclusion: The results show durable efficacy of cladribine tablets 3.5 mg/kg for reducing frequency and severity of relapses in patients with relapsing-remitting multiple sclerosis. CLARITY: NCT00213135; CLARITY Extension: NCT00641537
The role of perceived vulnerability in restaurant customers’ co-creation behavior and repatronage intention during the COVID-19 pandemic
Authors: Min Jihye , Yang Kiseol , Kim Jiyoung 
Published: May 2021

This study examines the antecedents of restaurant repatronage intention and the extent to which risk perception (i.e. perceived vulnerability) moderates the formation of that intention during the COVID-19 pandemic. Service fairness, trust, and co-creation behavior were investigated as the antecedents of restaurant diners’ repatronage intention formation process in the context of the COVID-19 pandemic. Using the data collected from people who had dined in a restaurant during the study period, a structural analysis was conducted with the Partial Least Squares method. The proposed model in the study explained a significant amount of the variance in the customers’ repatronage intention and partially supported the moderation effect of perceived vulnerability to COVID-19. The findings of the study contribute to advancing our knowledge of how the perceived vulnerability to COVID-19 leverages customers’ repatronage intention, which is affected by service fairness, trust, and co-creation behavior in the restaurant industry.
The treatment of sleep problems in autistic adults in the United Kingdom
Authors: Halstead Elizabeth , Sullivan Emma , Zambelli Zoe , Ellis Jason G , Dimitriou Dagmara 
Published: May 2021

Sleep problems are one of the most common complaints in autistic adults. This study aimed to report the perspectives of autistic adults in the United Kingdom on treatment of their sleep problems. A total of 288 autistic adults living in the United Kingdom completed an online survey including assessments of their sleep quality using the Pittsburgh Sleep Quality Index, reporting their experiences and preferences of sleep treatment with UK healthcare professionals and, their experiences of self-management of their sleep. Self-report data revealed 58% of participants had not attended a consultation with a healthcare professional regarding their sleep problem despite 90% meeting the criteria for poor sleep quality (based on the Pittsburgh Sleep Quality Index). Of the participants who attended a consultation for their sleep, 72% were prescribed medication and 60% were not satisfied with the outcome. Self-management of sleep problems was not effective for 80% of participants; 41% reported a preference for non-medication options such as education, advice and talking therapies for sleep treatment. This report highlights the need for a fundamental shift in the consideration of sleep problems in autistic adults given the high levels of co-morbidity. The development of successful management strategies in adulthood that importantly considering autistic adults’ preferences could reduce sleep problems and overall improve quality of life for autistic adults. Long term this could also reduce the need for prescribed medication in this population. Lay abstract Sleep problems are one of the most common complaints by autistic adults. This study aimed to report the perspectives of autistic adults on treatment of their sleep problems; 288 autistic adults living in the United Kingdom completed an online survey which assessed their sleep quality. We also gathered data on experiences and preferences of sleep treatment with UK healthcare professionals and their experiences of self-management of their sleep; 58% of autistic adults never had a visit with a healthcare professional regarding their sleep problem, despite 90% meeting the criteria for poor sleep quality. Some of those who attended a consultation for their sleep were prescribed medication (72%), but 60% were not satisfied with the outcome. The participants also reported that sleep self-management was not effective (80%); 41% reported a preference for non-medication including education, advice and talking therapies for sleep treatment. This report highlights the need for a fundamental shift in treatment of sleep problems in autistic adults. The current treatments are not resolving sleep issues; hence, it is imperative to develop management strategies that considers autistic adults’ preferences, reduces sleep problems and thus improves quality of life for autistic adults.
Prediction of Radiation Pneumonitis With Machine Learning in Stage III Lung Cancer: A Pilot Study
Authors: Yakar Melek , Etiz Durmus , Metintas Muzaffer , Ak Guntulu , Celik Ozer 
Published: May 2021

Background: Radiation pneumonitis (RP) is a dose-limiting toxicity in lung cancer radiotherapy (RT). As risk factors in the development of RP, patient and tumor characteristics, dosimetric parameters, and treatment features are intertwined, and it is not always possible to associate RP with a single parameter. This study aimed to determine the algorithm that most accurately predicted RP development with machine learning. Methods: Of the 197 cases diagnosed with stage III lung cancer and underwent RT and chemotherapy between 2014 and 2020, 193 were evaluated. The CTCAE 5.0 grading system was used for the RP evaluation. Synthetic minority oversampling technique was used to create a balanced data set. Logistic regression, artificial neural networks, eXtreme Gradient Boosting (XGB), Support Vector Machines, Random Forest, Gaussian Naive Bayes and Light Gradient Boosting Machine algorithms were used. After the correlation analysis, a permutation-based method was utilized for as a variable selection. Results: RP was seen in 51 of the 193 cases. Parameters affecting RP were determined as, total(t)V5, ipsilateral lung Dmax, contralateral lung Dmax, total lung Dmax, gross tumor volume, number of chemotherapy cycles before RT, tumor size, lymph node localization and asbestos exposure. LGBM was found to be the algorithm that best predicted RP at 85% accuracy (confidence interval: 0.73-0.96), 97% sensitivity, and 50% specificity. Conclusion: When the clinical and dosimetric parameters were evaluated together, the LGBM algorithm had the highest accuracy in predicting RP. However, in order to use this algorithm in clinical practice, it is necessary to increase data diversity and the number of patients by sharing data between centers.
Treatment of carotid cavernous sinus fistulas with flow diverters. A case report and systematic review
Authors: Stamatopoulos Theodosios , Anagnostou Evangelos , Plakas Sotirios , Papachristou Konstantinos , Lagos Panagiotis , Samelis Apostolos , Derakhshani Shahram , Mitsos Aristotelis 
Published: May 2021

Introduction Carotid cavernous fistulas (CCFs) are rare, usually follow head trauma or aneurysmal rupture. Recent treatment options include endovascular techniques such as flow diversion devices (FDDs). Objective To present our case treated with FDD application with transarterial cavernous-sinus coiling and present a systematic review on the use and effectiveness of FDDs in CCF treatment. Materials and methods We present our case of CCF treatment with FDD. A search was also conducted in PubMed, EMBASE and Cochrane until November 2020. Reference lists were also cross-checked. Results Including our case, thirty-eight patients were identified with a CCF that was treated with FDDs in sixteen studies. Twenty-two patients were females, nine were males and the rest unidentified. The mean age was 52,6 years (range 17–86, SD± 19.28). Thirty-six patients suffered from direct and two from indirect CCFs. Single FDD was used in four cases, single FDD with embolic materials in eleven cases, multiple overlapping FDDs were used in six cases and multiple overlapping FDDs with embolic materials were used in seventeen cases. Thirty-five patients (92,1%) had clinical improvement, immediate angiographic occlusion was seen in 44,7% of the cases, while long-term occlusion rate was 100% but with variable follow-up periods. One patient (2,6%) presented with a neurological deficit related to FDD deployment. Conclusion Targeted treatment of CCFs with single or overlapping FDDs with or without adjunct embolic agents offers a high success rate, both clinically and long-term angiographically compared to other endovascular methods alone. However, further research with multi-center prospective trials is warranted.
Novel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study
Authors: Seria Elisa , Galea George , Borg Joseph , Schembri Kevin , Grech Gabriella , Tagliaferro Sarah Samut , Felice Alexander 
Published: May 2021

Abstract
Background
Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation that impairs wound closure. Skin equivalent organotypic cultures can be engineered in vitro to study skin biology and wound closure by modelling the specific cellular components of the skin. This study aimed to develop a novel bioactive platelet-rich plasma (PRP) leukocyte depleted scaffold to facilitate the study of common clinical skin wounds in patients with poor chronic skin perfusion and low leukocyte infiltration. A scratch assay was performed on the skin model to mimic two skin wound conditions, an untreated condition and a condition treated with recombinant tumour necrotic factor (rTNF) to imitate the stimulation of an inflammatory state. Gene expression of IL8 and TGFA was analysed in both conditions. Statistical analysis was done through ANOVA and paired student t-test. P < 0.05 was considered significant.

Results
A skin model that consisted of a leukocyte-depleted, platelet-rich plasma scaffold was setup with embedded fibroblasts as dermal equivalents and seeded keratinocytes as multi-layered epidermis. Gene expression levels of IL8 and TGFA were significantly different between the control and scratched conditions (p < 0.001 and p < 0.01 respectively), as well as between the control and treated conditions (p < 0.01 and p < 0.001 respectively). The scratch assay induced IL8 upregulation after 3 h (p < 0.05) which continued to increase up to day 1 (p < 0.05). On the other hand, the administration of TNF led to the downregulation of IL8 (p < 0.01), followed by an upregulation on day 2. IL8 gene expression decreased in the scratched condition after day 1 as the natural healing process took place and was lower than in the treated condition on day 8 (p < 0.05).
Both untreated and treated conditions showed a downregulation of TGFA 3 h after scratch when compared with the control condition (p < 0.01). Administration of rTNF showed significant downregulation of TGFA after 24 h when compared with the control (p < 0.01) and treated conditions (p < 0.05).

Conclusion
This study suggests that a leukocyte-depleted PRP-based skin equivalent can be a useful model for the in vitro study of chronic skin wounds related to poor skin perfusion.
Using random forests to model 90-day hometime in people with stroke
Authors: Holodinsky Jessalyn K. , Yu Amy Y. X. , Kapral Moira K. , Austin Peter C. 
Published: May 2021

AbstractBackgroundNinety-day hometime, the number of days a patient is living in the community in the first 90 after stroke, exhibits a non-normal bucket-shaped distribution, with lower and upper constraints making its analysis difficult. In this proof-of-concept study we evaluated the performance of random forests regression in the analysis of hometime.MethodsUsing administrative data we identified stroke hospitalizations between 2010 and 2017 in Ontario, Canada. We used random forests regression to predict 90-day hometime using 15 covariates. Model accuracy was determined using ther-squaredstatistic. Variable importance in prediction and the marginal effects of each covariate were explored.ResultsWe identified 75,745 eligible patients. Median 90-day hometime was 59 days (Q1: 2, Q3: 83). Random forests predicted hometime with reasonable accuracy (adjusted r-squared 0.3462); no implausible values were predicted but extreme values were predicted with low accuracy. Frailty, stroke severity, and age exhibited inverse non-linear relationships with hometime and patients arriving by ambulance had less hometime than those who did not.ConclusionsRandom forests may be a useful method for analyzing 90-day hometime and capturing the complex non-linear relationships which exist between predictors and hometime. Future work should compare random forests to other models and focus on improving the accuracy of predictions of extreme values of hometime.
Effect of a figure-of-eight cerclage wire with two Kirschner wires on fixation strength for transverse metacarpal shaft fractures: an in vitro study with artificial bone
Authors: Chiu Yung-Cheng , Hsu Cheng-En , Ho Tsung-Yu , Ting Yen-Nien , Tsai Ming-Tzu , Hsu Jui-Ting 
Published: May 2021

Abstract
Background
Metacarpal shaft fractures are a common type of hand fracture. Despite providing strong fixation strength, plate fixation has numerous shortcomings. Concerning internal fixation with Kirschner wires (K-wires), although this approach is frequently used to treat metacarpal shaft fractures, the lack of functional stability may result in fixation failure.

Objective
To evaluate the effect of figure-of-eight cerclage wire on fixation for transverse metacarpal shaft fractures using two K-wires.

Materials and methods
We used a saw blade to create transverse metacarpal shaft fractures in 14 fourth-generation artificial third metacarpal bones (Sawbones, Vashon, WA, USA), which were assigned to groups undergoing fixation with two K-wires (KP) or with two K-wires and figure-of-eight cerclage wire (KP&F8). All specimens were subjected to material testing, specifically cantilever bending tests. The maximum fracture force and stiffness of the two fixation types were determined on the basis of the force–displacement data. The Mann–Whitney U test was used to compare between-group differences in maximum fracture force and stiffness.

Results
The maximum fracture force of the KP group (median ± interquartile range = 97.30 ± 29.70 N) was significantly lower than that of the KP&F8 group (153.2 ± 69.50 N, p < 0.05; Figure 5a), with the median of the KP&F8 group exceeding that of the KP group by 57.5%. Similarly, stiffness was significantly lower in the KP group (18.14 ± 9.84 N/mm) than in the KP&F8 group (38.25 ± 23.49 N/mm; p < 0.05; Figure 5b), with the median of the KP&F8 group exceeding that of the KP group by 110.9%.

Conclusion
The incorporation of a figure-of-eight cerclage wire increased the maximum fracture force and stiffness by 57.5 and 110.9%, respectively, compared with those achieved in standard two K-wire fixation. Therefore, hand surgeons are advised to consider the proposed approach to increase fixation strength.