bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility and Pregnancy Outcomes After Conservative Management of Adenocarcinoma In Situ of the Cervix
Authors: Bell Sarah G. , Peng Katie , Kobernik Emily K. , Miller Madison E. , Lieberman Richard , Saunders Natalie A. , Welch Kathryn C. , Campbell Elizabeth J. 
Published: August 2021

Objective
The aim of the study was to evaluate the pregnancy outcomes of women who underwent conservative management of adenocarcinoma in situ (AIS).

Materials and Methods
We conducted a retrospective chart review of patients diagnosed with AIS at a single tertiary institution between January 1, 1991, and December 31, 2019. We collected demographic data, AIS-specific information, and fertility outcomes and performed bivariate analyses to compare demographic characteristics and AIS-specific information between patients with and without hysterectomy after diagnosis. Patients with conservative management who achieved pregnancy were described.

Results
Among 87 patients with AIS, 38 (44%) underwent a hysterectomy within 6 months of diagnosis and 49 (56%) underwent conservative management. Six of 19 patients (32%) had residual AIS despite undergoing definitive management after an excisional procedure with negative margins and negative endocervical curettage (ECC). Nine of 19 patients (47%) had residual AIS after an excisional procedure with positive margins and/or a positive ECC. Patients who opted for conservative management were younger (median = 31.6 [interquartile range = 27.4–34.9] vs 38.5 y [32.3–44.8 y], p < .001) and nulligravid. Among patients with conservative management, there were 15 pregnancies and 14 live births (29%). Seven were preterm, although 2 were for medical indications.

Conclusions
Residual AIS in patients with negative margins and ECC leading to definitive hysterectomy (32%) and the rate of preterm birth (36%) were higher than previous reports and nationally reported rates. However, only 1 patient had a preterm birth before 34 weeks. These findings reflect important information for counseling patients who elect for conservative management of AIS.
Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?
Authors: Gurbel Paul A. , Bliden Kevin P. , Levy Jerrold H. , Walia Naval , Rapista Nicole , Cho Alastair , Jerjian Christophe , Tantry Udaya S. 
Published: August 2021

Standard biomarkers have been widely used for COVID-19 diagnosis and prognosis. We hypothesize that thrombogenicity metrics measured by thromboelastography will provide better diagnostic and prognostic utility versus standard biomarkers in COVID-19 positive patients. In this observational prospective study, we included 119 hospitalized COVID-19 positive patients and 15 COVID-19 negative patients. On admission, we measured standard biomarkers and thrombogenicity using a novel thromboelastography assay (TEG-6s). In-hospital all-cause death and thrombotic occurrences (thromboembolism, myocardial infarction and stroke) were recorded. Most COVID-19 patients were African--Americans (68%). COVID-19 patients versus COVID-19 negative patients had higher platelet-fibrin clot strength (P-FCS), fibrin clot strength (FCS) and functional fibrinogen level (FLEV) (P ≤ 0.003 for all). The presence of high TEG-6 s metrics better discriminated COVID-19 positive from negative patients. COVID-19 positive patients with sequential organ failure assessment (SOFA) score at least 3 had higher P-FCS, FCS and FLEV than patients with scores less than 3 (P ≤ 0.001 for all comparisons). By multivariate analysis, the in-hospital composite endpoint occurrence of death and thrombotic events was independently associated with SOFA score more than 3 [odds ratio (OR) = 2.9, P = 0.03], diabetes (OR = 3.3, P = 0.02) and FCS > 40 mm (OR = 3.4, P = 0.02).
This largest observational study suggested the early diagnostic and prognostic utility of thromboelastography to identify COVID-19 and should be considered hypothesis generating. Our results also support the recent FDA guidance regarding the importance of measurement of whole blood viscoelastic properties in COVID-19 patients. Our findings are consistent with the observation of higher hospitalization rates and poorer outcomes for African--Americans with COVID-19.
Oxytocin Regulates the Expression of Selected Colostrum‐derived microRNAs
Authors: Gutman‐Ido Einat , Reif Shimon , Musseri Mirit , Schabes Talia , Golan‐Gerstl Regina 
Published: August 2021

ABSTRACTObjective:The highly expressed microRNAs (miRNAs) in milk are known as beneficial miRNAs, such as mir148a‐3p, which is related to immune system development and disease prevention. There is a need to study their expression and secretion regulatory mechanism in breast milk. We hypothesize that oxytocin can be involved in the regulation of expression and secretion of milk‐derived miRNAs.Methods:Initially, oxytocin's effect on miRNA expression in human mammary cells was analyzed. Secondly, the expression of selected miRNAs in mothers’ colostrum treated or not with oxytocin before, during, or after labor was compared. MiRNA expression was analyzed by quantitative real‐time PCR.Results:The expression of miR‐148a was significantly upregulated, and miR‐320 downregulated in oxytocin‐treated mammary cells as well as their secreted extracellular vesicles to the media, compared with untreated cells. MiR‐148a was found to be upregulated, and miR‐320 was downregulated in the human colostrum of exogenous oxytocin‐treated mothers. Moreover, miR‐320 was highly expressed compared with miR‐148a in the colostrum of mothers that did not receive exogenous oxytocin. In contrast, in the milk of mothers who received exogenous oxytocin, the expression of miRNA‐148‐3p was highly expressed compared with miR‐320.Conclusions:This study shows that oxytocin modulates the expression of main milk‐derived miRNAs. Our findings provide a novel insight into oxytocin's role in milk composition by regulating miRNA expression. Our results implicate that oxytocin increases miRNA expression in mammary epithelial cells and human milk, affecting human milk composition and may contribute to further infant health.
Palleronia sediminis sp. nov. and Flavivirga algicola sp. nov., two marine bacteria isolated from offshore areas near Weihai
Authors: Sun Xun-Ke , Zhang Ya-Ning , Jia Yu-Yao , Zhong Yan-Lin , Chen Guan-Jun , Du Zong-Jun 
Published: August 2021

Two bacterial strains, designated SS33T and Y03T, were isolated from marine sediment and marine red alga collected on the coast of Weihai, PR China. Based on the results of 16S rRNA gene sequence analysis, strain SS33T was found to be closely related to

Primorskyibacter marinus

PX7T,

Pelagivirga dicentrarchi

YLY04T,

Palleronia marisminoris

DSM 26347T and

Maribius pontilimi

GH1-23T with 94.8, 94.6, 94.5 and 94.5 % sequence similarity; strain Y03T was found to be closest to

Flavivirga aquimarina

EC2D5T,

Flavivirga eckloniae

ECD14T and

Flavivirga amylovorans

JC2681T with 96.4, 96.1 and 96.0 % sequence similarity. Strain SS33T grew at 4–37 °C (optimum, 33 °C), at pH 6.0–9.5 (optimum, pH 7.5–8.0) and in the presence of 0–10 % (w/v) NaCl (optimum, 3.0 %). Chemotaxonomic analysis of strain SS33T showed that the predominant respiratory quinone was ubiquinone-10. The major fatty acids (>10.0 %) included C18 : 1
ω7c and C16 : 0. The major polar lipids included phosphatidylglycerol, phosphatidylcholine, one unidentified phospholipid, one unidentified glycolipid, one unidentified polar lipid and two unidentified aminolipids. Strain Y03T grew at 15–40 °C (optimum, 28 °C), at pH 6.5–8.0 (optimum, pH 7.0) and in the presence of 0.5–9.0 % (w/v) NaCl (optimum, 2.0%). Chemotaxonomic analysis showed that the predominant respiratory quinone was menaquinone-6. The major fatty acids (>10.0 %) included iso-C15 : 0, iso-C15 : 1 G, iso-C17 : 0 3-OH and iso-C15 : 0 3-OH. The major polar lipids included phosphatidylethanolamine, one unidentified phospholipid, one unidentified aminolipid and four unidentified polar lipids. Based on the polyphasic data, strain SS33T is considered to represent a novel species of the genus

Palleronia

, for which the name Palleronia sediminis sp. nov. is proposed, with the type strain SS33T (=KCTC 62986T=MCCC 1H00387T). Strain Y03T is considered to represent a novel species of the genus

Flavivirga

, for which the name Flavivirga algicola sp. nov. is proposed, with the type strain Y03T (=KCTC 72001T=MCCC 1H00386T).
Hematopoietic-SLC37A2 deficiency accelerates atherosclerosis in LDL receptor-deficient mice
Authors: Zhao Qingxia , Wang Zhan , Meyers Allison K. , Madenspacher Jennifer , Zabalawi Manal , Boudyguina Elena , Hsu Fang-Chi , McCall Charles M. , Furdui Cristina M. , Parks John S. , Fessler Michael B. , Zhu Xuewei 
Published: August 2021

AbstractMacrophages play a central role in the pathogenesis of atherosclerosis. Our previous study demonstrated that solute carrier family 37 member 2 (SLC37A2), an endoplasmic reticulum-anchored phosphate-linked glucose-6-phosphate transporter, negatively regulates macrophage Toll-like receptor activation by fine-tuning glycolytic reprogramming in vitro. Whether macrophage SLC37A2 impacts in vivo macrophage inflammation and atherosclerosis under hyperlipidemic conditions is unknown. We generated hematopoietic cell-specific SLC37A2 knockout and control mice in C57Bl/6 Ldlr-/- mice by bone marrow transplantation. Hematopoietic-specific SLC37A2 deletion in Ldlr-/- mice increased plasma lipid concentrations 12-16 wks of Western diet induction, attenuated macrophage anti-inflammatory responses, and resulted in more atherosclerosis compared to Ldlr-/- mice transplanted with wild type bone marrow. Aortic root intimal area was inversely correlated with plasma IL-10 levels, but not total cholesterol concentrations, suggesting inflammation but not plasma cholesterol was responsible for increased atherosclerosis in bone marrow SLC37A2-deficient mice. Our in vitro study demonstrated that SLC37A2 deficiency impaired IL-4-induced macrophage activation, independently of glycolysis or mitochondrial respiration. Importantly, SLC37A2 deficiency impaired apoptotic cell-induced glycolysis, subsequently attenuating IL-10 production. Our study suggests that SLC37A2 expression is required to support alternative macrophage activation in vitro and in vivo. In vivo disruption of hematopoietic SLC37A2 accelerates atherosclerosis under hyperlipidemic pro-atherogenic conditions.
Corporate social responsibility and financial performance: bidirectional relationship and mediating effect of customer loyalty: investigation in Sweden
Authors: Hichri Abir , Ltifi Moez 
Published: August 2021

PurposeThe study is based on a hybrid model composed of accounting and business data and is amongst the first to test the impact of corporate social responsibility (CSR) performance on the financial performance of the company, as well as the impact of financial performance on CSR performance. The bidirectional logic chosen by the study is rarely adopted in the global context and has never been tested in the Swedish context. Moreover, the purpose of this paper is to test the mediating effect of customer loyalty on the company’s CSR performance-financial performance relationship to assess this effect over the long term. This design has been neglected in previous studies.Design/methodology/approachData was collected from a sample of 110 Swedish companies during the period 2009–2019. This study collects the data from the Thomson Reuters Eikon database. A multiple regression analysis was performed to test the hypotheses.FindingsThe results confirmed the bidirectional relationship between CSR performance and company financial performance. This means that CSR performance positively influences the company’s financial performance. Similarly, financial performance positively influences the company’s CSR performance. Moreover, customer loyalty has a positive and significant mediating effect on the company’s CSR performance-financial performance relationship.Originality/valueThis study adds several inputs. The first contribution of the research is to test a hybrid model composed of accounting and commercial data. This model is amongst the first to test the impact of CSR performance on the financial performance of the company and the impact of financial performance on CSR performance. The second contribution is the bidirectional logic chosen by the study which is rarely adopted in the global context and has never been tested in the Swedish context. The third contribution is to test the mediating effect of customer loyalty on the company’s CSR performance-financial performance relationship to assess this effect over the long term. This design has been neglected in previous studies. The fourth contribution is the choice of the field of investigation for the reliability of the data used and the generalisation of the results obtained.
Conserving knowledge heritage: opportunities and challenges in conceptualizing cultural heritage information system (CHIS) in the Indian context
Authors: T.K. Gireesh Kumar , R. Raman Nair 
Published: August 2021

Purpose
The purpose of this paper is to investigate the scope, issues and challenges in conceptualizing a comprehensive cultural heritage information system (CHIS) in the Indian context and examines the feasibility of designing such a system with the support of advanced conservation strategies and technological aids.

Design/methodology/approach
As the conservation efforts and its sustenance requires the support of a knowledge base cum digital archiving tool, comprehensions on the availability and usage of different software tools are indispensable. Assessing the availability of controlled vocabularies, ontology frameworks, metadata standards, classification schemes and architectural designs, language compatibility for implementing cultural heritage system is inevitable for developing CHIS. The present study examines the availability of such schemes and systems and emphasis the need for developing a reliable information system.

Findings
A comprehensive system at the country level to efficiently document, manage and update the knowledge on cultural heritage is required. CHIS created can be engaged in visualizing the cultural heritages of the country and can act as an interactive multimedia documentation system. The virtual recreation of cultural heritage in a holistic manner can also ensure its long-term sustainability.

Originality/value
The digital archive of different expressions will be a rich source of data for research, administration and development. The archive developed should cover the cultural heritage depicted in the form of published documents, images, audios and videos, documents and visuals on performing arts, buildings, sculptures, ecosystem, monuments, utensils, etc. and the history and knowledge pertaining to them and any other property belonging to the heritage.
Duality and stability of MHD Darcy–Forchheimer porous medium flow of rotating nanofluid on a linear shrinking/stretching sheet: Buongiorno model
Authors: Raza Jawad , Dero Sumera , Lund Liaquat Ali , Omar Zurni 
Published: August 2021

Purpose
The purpose of study is to examine the dual nature of the branches for the problem of Darcy–Forchheimer porous medium flow of rotating nanofluid on a linearly stretching/shrinking surface under the field of magnetic influence. The dual nature of the branches confronts the uniqueness and existence theorem, moreover, mathematically it is a great achievement. For engineering purposes, this study applied a linear stability test on the multiple branches to determine which solution is physically reliable (stable).

Design/methodology/approach
Nanofluid model has been developed with the help of Buongiorno model. The partial differential equations in space coordinates for the law of conservation of mass, momentum and energy have been transformed into ordinary differential equations by introducing the similarity variables. Two numerical techniques, namely, the shooting method in Maple software and the three-stage Lobatto IIIA method in Matlab software, have been used to find multiple branches and to accomplish stability analysis, respectively.

Findings
The parametric investigation has been executed to find the multiple branches and explore the effects on skin friction, Sherwood number, Nusselt number, concentration and temperature profiles. The findings exhibited the presence of dual branches only in the case of a shrinking sheet.

Originality/value
The originality of work is a determination of multiple branches and the performance of the stability analysis of the branches. It has also been confirmed that such a study has not yet been considered in the previous literature.
Design and implementation of pervasive DA based FIR filter and feeder register based multiplier for software definedradio networks
Authors: Kumar B.N. Mohan , Rangaraju H.G. 
Published: August 2021

Purpose
Digital signal processing (DSP) applications such as finite impulse response (FIR) filter, infinite impulse response and wavelet transformation functions are mainly constructed using multipliers and adders. The performance of any digital applications is dependent on larger size multipliers, area and power dissipation. To optimize power and area, an efficient zero product and feeder register-based multiplier (ZP and FRBM) is proposed. Another challenging task in multipliers is summation of partial products (PP), results in more delay. To address this issue, the modified parallel prefix adder (PPA) is incorporated in multiplier design. In this work, different methods are studied and analyzed for designing FIR filter, optimized with respect to area, power dissipation, speed, throughput, latency and hardware utilization.

Design/methodology/approach
The distributed arithmetic (DA)-based reconfigurable FIR design is found to be suitable filter for software-defined radio (SDR) applications. The performance of adder and multipliers in DA-FIR filter restricts the area and power dissipation due to their complexity in terms of generation of sum and carry bits. The hardware implementation time of an adder can be reduced by using PPA which is based on Ling equation. The MDA-RFIR filter is designed for higher filter length (N), i.e. N = 64 with 64 taps and this design is developed using Verilog hardware description language (HDL) and implemented on field-programmable gate array. The design is validated for SDR channel equalizer; both RFIR and SDR are integrated as single system and implemented on Artix-7 development board of part name XC7A100tCSG324.

Findings
The MDA-RFIR for N = 64 is optimized about 33% in terms of area-delay, power-speed product and energy efficiency. The theoretical and practical comparisons have been done, and the practically obtained results are compared with existing DA-RFIR designs in terms of throughput, latency, area-delay, power-speed product and energy efficiency are better about 3.5 times, 31, 45 and 29%, respectively.

Originality/value
The MDA-RFIR for N = 64 is optimized about 33% in terms of area-delay, power-speed product and energy efficiency.
CEO duality, earnings quality and board independence
Authors: Alves Sandra 
Published: August 2021

Purpose
This study draws on agency, theory to evaluate the relationship between chief executive officer (CEO) duality and earnings quality, proxied by discretionary accruals. Additionally, this study aims to examine whether board independence moderates the relationship between CEO duality and earnings quality.

Design/methodology/approach
This study uses a fixed-effects regression model to examine the effect of CEO duality on earnings quality and to test whether board independence moderates that relationship for a sample of non-financial listed Portuguese firms-year from 2002 to 2016.

Findings
Consistent with agency theory, this study suggests that CEO duality decreases earnings quality. Further, the results also suggest that the earnings quality reduction associated with CEO duality is attenuated when the board of directors has a higher proportion of independent directors.

Practical implications
The findings based on this study provide useful information to investors and regulators in evaluating the impact of CEO duality on earnings quality and the effect of board independence on the role of CEO duality, especially under concentrated ownership.

Originality/value
To the knowledge, this study is the first to investigate the role of board independence on the association between CEO duality and earnings quality. In addition, this paper is the first empirical study to investigate the direct and indirect effect of CEO duality on earnings quality in Portugal.
Dynamic prediction of traffic incident duration on urban expressways: a deep learning approach based on LSTM and MLP
Authors: Zhu Weiwei , Wu Jinglin , Fu Ting , Wang Junhua , Zhang Jie , Shangguan Qiangqiang 
Published: August 2021

PurposeEfficient traffic incident management is needed to alleviate the negative impact of traffic incidents. Accurate and reliable estimation of traffic incident duration is of great importance for traffic incident management. Previous studies have proposed models for traffic incident duration prediction; however, most of these studies focus on the total duration and could not update prediction results in real-time. From a traveler’s perspective, the relevant factor is the residual duration of the impact of the traffic incident. Besides, few (if any) studies have used dynamic traffic flow parameters in the prediction models. This paper aims to propose a framework to fill these gaps.Design/methodology/approachThis paper proposes a framework based on the multi-layer perception (MLP) and long short-term memory (LSTM) model. The proposed methodology integrates traffic incident-related factors and real-time traffic flow parameters to predict the residual traffic incident duration. To validate the effectiveness of the framework, traffic incident data and traffic flow data from Shanghai Zhonghuan Expressway are used for modeling training and testing.FindingsResults show that the model with 30-min time window and taking both traffic volume and speed as inputs performed best. The area under the curve values exceed 0.85 and the prediction accuracies exceed 0.75. These indicators demonstrated that the model is appropriate for this study context. The model provides new insights into traffic incident duration prediction.Research limitations/implicationsThe incident samples applied by this study might not be enough and the variables are not abundant. The number of injuries and casualties, more detailed description of the incident location and other variables are expected to be used to characterize the traffic incident comprehensively. The framework needs to be further validated through a sufficiently large number of variables and locations.Practical implicationsThe framework can help reduce the impacts of incidents on the safety of efficiency of road traffic once implemented in intelligent transport system and traffic management systems in future practical applications.Originality/valueThis study uses two artificial neural network methods, MLP and LSTM, to establish a framework aiming at providing accurate and time-efficient information on traffic incident duration in the future for transportation operators and travelers. This study will contribute to the deployment of emergency management and urban traffic navigation planning.