bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motivational interviewing with community-dwelling older adults after hip fracture (MIHip): protocol for a randomised controlled trial
Authors: Taylor Nicholas F , O"Halloran Paul D , Watts Jennifer J , Morris Rebecca , Peiris Casey L , Porter Judi , Prendergast Luke A , Harding Katherine E , Snowdon David A , Ekegren Christina L , Hau Raphael , Mudiyanselage Shalika B , Rimayanti Made U , Noeske Kate E , Snowdon Megan , Kim Daniel , Shields Nora 
Published: June 2021

IntroductionCommunity-dwelling people recovering from hip fracture have the physical capacity to walk in their community but lack the confidence to do so. The primary aim of this trial is to determine whether motivational interviewing increases time spent walking at 12 months in community-dwelling people after hip fracture compared with an attention placebo control group. Secondary aims are to evaluate cost effectiveness, patient and health service outcomes and to complete a process evaluation.Methods and analysisAn assessor-blinded parallel group randomised controlled design with embedded health economic evaluation and process evaluation will compare the effects of n=270 participants randomly allocated to an experimental group (motivational interviewing) or a control group (dietary advice). For inclusion, participants are aged ≥65 years, living at home independently within 6 months of discharge from hospital after hip fracture and able to walk independently and communicate with conversational English. Key exclusion criteria are severe depression or anxiety, impaired intellectual functioning and being medically unstable to walk. Participants allocated to the experimental group will receive 10 (8 weekly and 2 booster) telephone-based sessions of motivational interviewing to increase walking over 16 weeks. Participants allocated to the control group will receive an equivalent dose of telephone-based dietary advice. The primary outcome is daily time spent walking over 7 days assessed at weeks 0, 9, 26 and 52. Secondary outcomes include measures of psychological-related function, mobility-related function, community participation, health-related quality of life and falls. Health service utilisation and associated costs will be assessed. Process evaluation will assess the fidelity of the motivational interviewing intervention and explore contextual factors through semistructured interviews.Ethics and disseminationEthical approval obtained from Eastern Health (E19-002), Peninsula Health (50261/EH-2019), Alfred Health (617/20) and La Trobe University (E19/002/50261). The findings will be disseminated in peer-reviewed journals, conference presentations and public seminars.Trial registration numberACTRN12619000936123.
Evaluation of risk mitigation measures for people with substance use disorders to address the dual public health crises of COVID-19 and overdose in British Columbia: a mixed-method study protocol
Authors: Nosyk Bohdan , Slaunwhite Amanda , Urbanoski Karen , Hongdilokkul Natt , Palis Heather , Lock Kurt , Min Jeong E , Zhao Bin , Card Kiffer G , Barker Brittany , Meilleur Louise , Burmeister Charlene , Thomson Erica , Beck-McGreevy Phoenix , Pauly Bernie 
Published: June 2021

IntroductionThe COVID-19 pandemic was preceded by an ongoing overdose crisis and linked to escalating drug overdose deaths in British Columbia (BC). At the outset of these dual public health emergencies, the BC government announced interim Risk Mitigation Guidance (RMG) that permitted prescribing medication alternatives to substances, including opioids, alcohol, stimulants and benzodiazepines, an intervention sometimes referred to as ‘safe supply’. This protocol outlines the approach for a study of the implementation of RMG and its impacts on COVID-19 infection, drug-related and systemic harms, continuity of care for people with substance use disorder (SUD), as well as their behavioural, psychosocial and well-being outcomes.Methods and analysisWe conducted a parallel mixed-method study that involved both analysis of population-level administrative health data and primary data collection, including a 10-week longitudinal observational study (target n=200), a cross-sectional survey (target n=200) and qualitative interviews (target n=60). We implemented a participatory approach to this evaluation, partnering with people with lived or living expertise of drug use, and researchers and public health decision-makers across the province. Linked population-level administrative databases will analyse data from a cohort of BC residents with an indication of SUD between 1996 and 2020. We will execute high-dimensional propensity score matching and marginal structural modelling to construct a control group and to assess the impact of RMG dispensation receipt on a collaboratively determined set of primary and secondary outcomes.Ethics and disseminationStudy activities were developed to adhere to the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans, recommended COVID-19 research practices, and guided by the Truth and Reconciliation Commission’s Calls to Action for public health, data governance and research ethics related to Indigenous people. Results will be disseminated incrementally, on an ongoing basis, through the consortium established for this study, then published in peer-reviewed journals.
Linking Twitter and survey data: asymmetry in quantity and its impact
Authors: Al Baghal Tarek , Wenz Alexander , Sloan Luke , Jessop Curtis 
Published: June 2021

AbstractLinked social media and survey data have the potential to be a unique source of information for social research. While the potential usefulness of this methodology is widely acknowledged, very few studies have explored methodological aspects of such linkage. Respondents produce planned amounts of survey data, but highly variant amounts of social media data. This study explores this asymmetry by examining the amount of social media data available to link to surveys. The extent of variation in the amount of data collected from social media could affect the ability to derive meaningful linked indicators and could introduce possible biases. Linked Twitter data from respondents to two longitudinal surveys representative of Great Britain, the Innovation Panel and the NatCen Panel, show that there is indeed substantial variation in the number of tweets posted and the number of followers and friends respondents have. Multivariate analyses of both data sources show that only a few respondent characteristics have a statistically significant effect on the number of tweets posted, with the number of followers being the strongest predictor of posting in both panels, women posting less than men, and some evidence that people with higher education post less, but only in the Innovation Panel. We use sentiment analyses of tweets to provide an example of how the amount of Twitter data collected can impact outcomes using these linked data sources. Results show that more negatively coded tweets are related to general happiness, but not the number of positive tweets. Taken together, the findings suggest that the amount of data collected from social media which can be linked to surveys is an important factor to consider and indicate the potential for such linked data sources in social research.
Prevalence of Hepatic Encephalopathy from a Commercial Medical Claims Database in the United States
Authors: Potnis Aniruddha , VanMeter Susan , Stange Jan 
Published: June 2021

Introduction. Hepatic encephalopathy (HE), a complication of cirrhosis, is associated with increased healthcare resource utilization and mortality, and impaired quality of life. Information on the prevalence of HE in the US general population is limited. Methods. Prevalence of HE was estimated by sequential stepwise data analysis of the Symphony Health anonymized patient-level data (APLD) claims database. First,

patients
≥
18

years with International Classification of Diseases ninth/tenth edition, clinical modification (ICD-9/10-CM), and codes for cirrhosis from 2018 medical and hospital claims were used to estimate prevalence of cirrhosis within the data set and number of patients with cirrhosis in the US general population. Second, patients diagnosed with cirrhosis in the APLD data set from 2015–2016 with an HE ICD-9/10-CM code within 1 year of cirrhosis diagnosis were used to deduce the prevalence of HE within the data set and estimate the number of patients with HE in the US general population. Last, US DiagnosticSource data on serum ammonia level laboratory results measured within ±2 days of a confirmed HE event were merged with the APLD HE data set, then applied to the US general population. Results. Medical and hospital claims data were available for 272,256 patients with cirrhosis in 2018. An estimated 536,856 US adults had a diagnosis of cirrhosis (prevalence of 0.21%) in 2018. This proportion applied to the estimated number of patients with cirrhosis in the United States resulted in a prevalence estimate of 201,858 cirrhosis patients with HE in 2018. When factoring in serum ammonia data, prevalence was conservatively estimated as approximately 196,000 cirrhosis patients with HE and serum ammonia

levels
>
21

μ
mol
/
L

. Conclusions. In this longitudinal cohort–based study, it was estimated that ≈202,000 patients had HE in the United States in 2018, representing a considerable burden to society and payers.
Prediagnostic White Blood Cell DNA Methylation and Risk of Breast Cancer in the Prostate Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort
Authors: Sturgeon Susan R. , Sela David A. , Browne Eva P. , Einson Jonah , Rani Asha , Halabi Mohamed , Kania Thomas , Keezer Andrew , Balasubramanian Raji , Ziegler Regina G. , Schairer Catherine , Kelsey Karl T. , Arcaro Kathleen F. 
Published: June 2021

Abstract

Background:
White blood cell (WBC) DNA may contain methylation patterns that are associated with subsequent breast cancer risk. Using a high-throughput array and samples collected, on average, 1.3 years prior to diagnosis, a case–cohort analysis nested in the prospective Sister Study identified 250 individual CpG sites that were differentially methylated between breast cancer cases and noncases. We examined five of the top 40 CpG sites in a case–control study nested in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort.

Methods:
We investigated the associations between prediagnostic WBC DNA methylation in 297 breast cancer cases and 297 frequency-matched controls. Two WBC DNA specimens from each participant were used: a proximate sample collected 1 to 2.9 years and a distant sample collected 4.2–7.3 years prior to diagnosis in cases or the comparable timepoints in controls. WBC DNA methylation level was measured using targeted bisulfite amplification sequencing. We used logistic regression to obtain ORs and 95% confidence intervals (CI).

Results:
A one-unit increase in percent methylation in ERCC1 in proximate WBC DNA was associated with increased breast cancer risk (adjusted OR = 1.29; 95% CI, 1.06–1.57). However, a one-unit increase in percent methylation in ERCC1 in distant WBC DNA was inversely associated with breast cancer risk (adjusted OR = 0.83; 95% CI, 0.69–0.98). None of the other ORs met the threshold for statistical significance.

Conclusions:
There was no convincing pattern between percent methylation in the five CpG sites and breast cancer risk.

Impact:
The link between prediagnostic WBC DNA methylation marks and breast cancer, if any, is poorly understood.
A Phase Ib Open-Label, Multicenter Study of Inhaled DV281, a TLR9 Agonist, in Combination with Nivolumab in Patients with Advanced or Metastatic Non–small Cell Lung Cancer
Authors: Garon Edward B. , Spira Alexander I. , Johnson Melissa , Bazhenova Lyudmila , Leach Joseph , Cummings Amy L. , Candia Albert , Coffman Robert L. , Janatpour Mary J. , Janssen Robert , Gamelin Erick , Chow Laura Q.M. 
Published: June 2021

Abstract

Purpose:
Although PD-(L)1 inhibitors have shown efficacy in advanced/metastatic non–small cell lung cancer (NSCLC), many patients do not respond to this treatment and more effective combinations with acceptable toxicities are needed. To assess the potential benefit of combining localized innate immune stimulation with checkpoint blockade, the TLR9 agonist DV281 was combined with nivolumab in a phase Ib study.

Patients and Methods:
Patients after one or two prior lines of systemic therapy were enrolled in a dose-escalation study with a 3+3 design. DV281 was administered via inhalation in five dose cohorts at 1 to 25 mg; nivolumab 240 mg was administered intravenously every 2 weeks. Safety, tolerability, pharmacodynamics, and response to treatment were assessed.

Results:
Twenty-six patients with advanced NSCLC enrolled. Baseline programmed death ligand 1 (PD-L1) expression was present in 16 patients (61.5%); 21 (80.7%) had received previous anti–PD-1/PD-L1. Thirteen patients (50%) had stable disease, nine (34.6%) had progressive disease, and four (15.4%) were not evaluable. Median duration of disease control was 124 days. Adverse events were seen in 16 patients (61.5%), mostly grade 1/2 chills, fatigue, flu-like symptoms, diarrhea, and rash; there was only one grade 3 adverse event (dyspnea). Pharmacodynamic assessment, measured by IFN- inducible gene expression, showed target engagement in all dose cohorts. Systemic pharmacodynamic responses plateaued in the 2 highest dose cohorts.

Conclusions:
DV281 with nivolumab was well tolerated with target engagement observed at every dose. Pharmacodynamic advantages at doses above 10 mg were unclear. The long duration of disease control in 50% of patients suggests clinically relevant activity in this population of heavily pretreated patients.
A NGS-based Blood Test For the Diagnosis of Invasive HPV-associated Carcinomas with Extensive Viral Genomic Characterization
Authors: Sastre-Garau Xavier , Diop Mamadou , Martin Fernando , Dolivet Gilles , Marchal Frédéric , Charra-Brunaud Claire , Peiffert Didier , Leufflen Léa , Dembélé Birama , Demange Jessica , Tosti Priscillia , Thomas Jacques , Leroux Agnès , Merlin Jean-Louis , Diop-Ndiaye Halimatou , Costa Jean-Marc , Salleron Julia , Harlé Alexandre 
Published: June 2021

Abstract

Purpose:
Use of circulating tumor DNA (ctDNA) for diagnosis is limited regarding the low number of target molecules in early-stage tumors. Human papillomavirus (HPV)–associated carcinomas represent a privileged model using circulating viral DNA (ctHPV DNA) as a tumor marker. However, the plurality of HPV genotypes represents a challenge. The next-generation sequencing (NGS)-based CaptHPV approach is able to characterize any HPV DNA sequence. To assess the ability of this method to establish the diagnosis of HPV-associated cancer via a blood sample, we analyzed ctHPV DNA in HPV-positive or HPV-negative carcinomas.

Experimental Design:
Patients (135) from France and Senegal with carcinoma developed in the uterine cervix (74), oropharynx (25), oral cavity (19), anus (12), and vulva (5) were prospectively registered. Matched tumor tissue and blood samples (10 mL) were taken before treatment and independently analyzed using the CaptHPV method.

Results:
HPV prevalence in tumors was 60.0% (81/135; 15 different genotypes). Viral analysis of plasmas compared with tumors was available for 134 patients. In the group of 80 patients with HPV-positive tumors, 77 were also positive in plasma (sensitivity 95.0%); in the group of 54 patients with HPV-negative tumors, one was positive in plasma (specificity 98.1%). In most cases, the complete HPV pattern observed in tumors could be established from the analysis of ctHPV DNA.

Conclusions:
In patients with carcinoma associated with any HPV genotype, a complete viral genome characterization can be obtained via the analysis of a standard blood sample. This should favor the development of noninvasive diagnostic tests providing the identification of personalized tumor markers.
See related commentary by Rostami et al., p. 5158
The Plausible Impossible: Chinese Adults Hold Graded Notions of Impossibility
Authors: Gong Tianwei , Shtulman Andrew 
Published: June 2021

Abstract
Events that violate the laws of nature are, by definition, impossible, but recent research suggests that people view some violations as “more impossible” than others (Shtulman & Morgan, 2017). When evaluating the difficulty of magic spells, American adults are influenced by causal considerations that should be irrelevant given the spell’s primary causal violation, judging, for instance, that it would be more difficult to levitate a bowling ball than a basketball even though weight should no longer be a consideration if contact is no longer necessary for support. In the present study, we sought to test the generalizability of these effects in a non-Western context – China – where magical events are represented differently in popular fiction and where reasoning styles are often more holistic than analytic. Across several studies, Chinese adults (n = 466) showed the same tendency as American adults to honor implicit causal constraints when evaluating the plausibility of magical events. These findings suggest that graded notions of impossibility are shared across cultures, possibly because they are a byproduct of causal knowledge.
Promoting Industrial Success through Organizational Culture
Authors: Moskovich Yaffa 
Published: June 2021

Abstract
This study shows the value of promoting organizational culture by identifying and analyzing factors of economic success in a particular factory. The research was conducted by qualitative investigation using ethnographic interviews and document analysis procedures. The findings describe how the managers merged socialist traditions of the pre-privatized kibbutz and the capitalism of the global market in order to create a dynamic strategic model. The components of the model interacted with each other, creating an unusual organizational culture and a porous boundary between the factory and the kibbutz community that owned it. The findings suggest that there are advantages to preserving the unique cultural attributes that link workers, managers and their surrounding community which reflect their roots and basic mindset. This case study offers managers of kibbutz, and non-kibbutz, factories a successful example of combining opposite trends in management style. The main contribution of this study is presenting an alternative method for examining kibbutz industries in future research. This alternative method describes a managerial culture that facilitates the combination of two seemingly contradictory paradigms. The first is the kibbutz’s socialist, cooperative, and communal principles. The second paradigm is the external capitalist realities of the domestic and global market.
The Role of ‘Spirituality’ in Religion-secular Relational Discourse: The Case of Yoga in Britain
Authors: Vollmer Laura J. 
Published: June 2021

Abstract
This article examines the ‘relational etymology’ of the term ‘secular’ relative to ‘religion’ and the role of the concept ‘spirituality’ in discursive change. Employing a relational methodology to the sociology of knowledge approach to discourse analysis, concept formation and transformation of these terms is considered as a specific matter of how the terms are positioned relative to one another in the discourse. It is found that while ‘spirituality’ first worked on the side of ‘religion’ to differentiate it from the ‘secular,’ it was later differentiated from ‘religion’ and placed in ‘secular’ discourse. This is exemplified with the case of yoga in Britain. Implications for the religion-secular relationship and the secularization thesis are explored.
Angels as the Shape of Energy: How the Threshold Narratives Shaped the Meaning Construction of ‘Angel’ and ‘Energy’ in a Central and Eastern European New Religious Group
Authors: Csáji László Koppány 
Published: June 2021

Abstract
The status-dependent access to information results in multilevel meaning construction in a charismatic Christian group. The notion of ‘angel’ is discursively transforming (during evangelization rituals, healing, angel visions, etc.). To acquire language skills, one may encounter and accept threshold narratives. After the notion of energy was introduced into the group (2012), former ideas (‘rectangular form’ and ‘shape-changing kind’ of angels) were intermixed with it. Energy became a general, fundamental principle, but it was not obvious how they could manage its dual kind: ‘positive energy’ and the evil counterpart (‘spiritual/negative energy’). My argumentation is based on discourse analysis and cognitive semantics.
The Referral of the Situation in Venezuela to the International Criminal Court: The Office of the Prosecutor Should Not Step In… Yet
Authors: Garfunkel Ianiv 
Published: June 2021

Abstract
On 26 September 2018, six American States Parties to the Rome Statute referred the Situation in Venezuela to the Office of the Prosecutor (‘OTP’) of the International Criminal Court, regarding crimes against humanity. Those States rested on Article 14 of the Rome Statute to proceed. That referral – namely, crimes committed outside the territory of the referring State(s) – was the second of its kind received by the icc in its more than 15-year working history. The otp is currently considering the referral under the so-called ‘Preliminary Examination’ stage, wherein the admissibility test is likely to be addressed within the complementarity principle, according to Article 17 of the Rome Statute. Despite the duty to exercise their criminal jurisdiction, as the Preamble to the Rome Statue stipulates, and the fact that those six American States recognize some sort of extraterritorial jurisdiction, those States remained inactive. What should the otp do when six democracies, who are able to act, do not even try to launch an investigation for crimes they have expressed concerns about, without providing an explanation for their inactivity? This article will analyse how the otp should deal with this referral in terms of the complementarity principle, having regard to the positive approach to complementarity. Accordingly, it will be argued that the Prosecutor should refrain from intervening until those States attempt to act and/or, in case of legal or factual inability, justify the referral.
Presenting an Admirable Self: Moral Evaluation within the Interview
Authors: Dubie Emily Z. 
Published: June 2021

Abstract
This article considers the complicated nature of self-reporting within the in-depth interview. Despite the adoption of ethnographic methods in Christian ethics and related disciplines, the accuracy of interview data has received relatively little attention. Drawing upon my fieldwork with Christian social workers in the American southeast, as well as sociological and anthropological sources, I argue that research participants frequently endeavor to present an admirable portrait of themselves. Through selecting, omitting, and revising their stories, they undertake a kind of moral work, assessing their actions and attitudes according to available ethical criteria. Broader cultural norms, their own moral ideals, and anticipations of the interviewer’s judgments all supply resources for self-evaluation. Rather than presenting a methodological problem, understanding this possible dynamic within the interview supplies the Christian ethicist with firsthand insights into the moral labors of naming a good life.