bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iberoccitanemys atlanticum (Lapparent de Broin & Murelaga, 1996) n. comb.: new data on the diversity and paleobiogeographic distributions of the Campanian-Maastrichtian bothremydid turtles of Europe
Authors: PÉREZ-GARCÍA Adán , ORTEGA Francisco , MURELAGA Xabier 
Published: August 2021

Bothremydidae is the most abundant clade of turtles in the Campanian and Maastrichtian (Upper Cretaceous) fossil record of southwestern Europe. Several members of Foxemydina Gaffney, Tong & Meylan, 2006 are known in an area that includes Southern France and the North-Eastern half of Spain. The problematic ‘Polysternon’ atlanticum is the worst characterized, lacking a diagnosis that allows its specific validity to be confirmed, and whose generic attribution has been recognized as doubtful. Its presence was exclusively proposed in its type locality, the upper Campanian quarry of Laño, in Treviño County (Burgos Province, North of Spain). Despite the fact that knowledge about Bothremydidae has markedly increased after the description of ‘Polysternon’ atlanticum Lapparent de Broin & Murelaga, 1996, no new information about this species has been published since the 1990s. The analysis of abundant unpublished material of the bothremydid from Laño allows us to confirm the validity of this species. As a consequence of this study, it is not only identified in its type locality, but also in other Spanish regions and in the south of France. The diversity of Bothremydidae Baur, 1891 in the Upper Cretaceous of Europe is lower than previously considered. Thus, the species ‘Iberoccitanemys convenarum’ (Laurent, Tong & Claude, 2002), originally defined for the French record, and subsequently also identified in Spain, is identified here as a synonym of the species described in Laño. An emended diagnosis for the upper Campanian to upper Maastrichtian, Iberoccitanemys atlanticum (Lapparent de Broin & Murelaga, 1996) n. comb., is proposed.
Autonomic, hormonal, and subjective responses to a modified version of the TSST: a pilot study
Authors: Espín López Laura , Salvador Alicia , Gómez-Amor Jesús 
Published: August 2021

El objetivo de esta investigación fue estudiar las respuestas hormonales, autonómicas y afectivas a una versión modificada del estresor TSST en una muestra de jóvenes universitarios compuesta de treinta y ocho sujetos (11 hombres y veintisiete mujeres, 11 en la fase lútea del ciclo menstrual, 16 mujeres en la fase folicular). La respuesta hormonal se evaluó con niveles de cortisol. La frecuencia cardíaca y la actividad electrodérmica se registraron durante toda la sesión experimental y la ansiedad rasgo y estado se evaluaron antes y después de la tarea. La fase de discurso provocó la frecuencia cardíaca más alta, la mayor frecuencia de respuestas inespecíficas y el mayor nivel de conductancia de la piel, mostrando diferencias significativas con la fase de habituación. Sin embargo, la respuesta de cortisol salival no fue significativa con
respecto al factor estresante. En relación con las diferencias de sexo, independientemente del factor estresante,los hombres mostraron una mayor frecuencia de respuesta inespecífica, un mayor nivel de conductancia de la piel que las mujeres y mayores niveles de cortisol en comparación con las mujeres en la fase lútea. La ansiedad estado fue similar pre y postarea y no reveló ninguna diferencia asociada con el sexo o la fase del ciclo menstrual. Nuestros resultados sugieren que el eje HHA no responde al TSST sentado y proporcionó evidencia de que el TSST provoca diferentes patrones de respuesta psicofisiológica dependiendo de algunas variaciones del protocolo.
The aim of this research was to study hormonal, autonomic and affective responses to a modified version of the stressor TSST in a sample of young university students composed for thirty-eight subjects (11 men and twenty seven women, 11 in the luteal phase of the menstrual cycle, 16 women in the follicular phase). The hormonal response was evaluated with levels of cortisol. Heart rate and Electrodermal Activity were recorded during all the experimental session and trait-state anxiety was evaluated before and after the task. The speech phase elicited the highest heart rate, frequency of non-specific response and skin conductance level, showing significant differences mainly with the habituation phase. However, the salivary cortisol response was not significant with respect to stressor. In relation with sex differences, regardless of the stressor, menshowed higher frequency of non-specific response, greater skin conductance level than women and higher cortisol levels in comparison with women in the luteal phase. State-anxiety was similar pre-/post task and did not reveal any difference associated to sex or menstrual cycle phase. Our results suggest that the HPA axis not response to sitting TSST and provided evidence that TSST elicits different pattern of psychophysiological response depending on some protocol variations.
Señales de amenaza y sesgo atencional en lafobia a la sangre, inyecciones y heridasy en la fobia a las serpientes
Authors: Sánchez-Navarro Juan Pedro , Martínez-Selva José M. , Kosonogov Vladimir , Carrillo-Verdejo Eduvigis , Pineda Sara , Torrente Ginesa 
Published: August 2021

El objetivo de esta investigación fue estudiar el efecto de una señal que indica la aparición de una imagen fóbica sobre la actividad electrocortical provocada por el estímulo relevante para el trastorno en la fobia a la sangre por lesión en inyección (BII) y la fobia a las serpientes. Una muestra de 13 participantes con fobia BII, 12 individuos con fobia a las serpientes y 14 controles no fóbicos se sometieron a una tarea S1-S2, donde S1 era una palabra que describía el contenido de una imagen posterior (relacionada con la sangre, serpiente y neutral) que apareció 2 segundos después (S2). Obtuvimos las amplitudes ERP P200 y P300 provocadas por las imágenes. Nuestros resultados revelan que P200 no diferenciaba entre el contenido de las imágenes en la fobia BII mientras que, por el contrario, las imágenes relacionadas con la serpiente y la sangre provocaron las respuestas más grandes en los participantes con fobia a las serpientes. Tanto las imágenes relacionadas con la sangre como las de serpientes provocaron amplitudes de P300 mayores que las imágenes neutrales en todos los grupos. Las señales de amenaza redujeron la reacción electrocortical del BII, posiblemente por la provocación de respuestas anticipatorias o reguladoras. Estos resultados son indicativos de una baja atención automática exógena hacia los estímulos temidos en la fobia BII, como lo revela P200, probablemente relacionado con una falta de sesgo de atención al objeto fóbico.
The aim of this research was to study the effect of a cue signalling the upcoming of a phobic picture on the electrocortical activity provoked by the disorder-relevant stimulus in in blood-injection-injury (BII) phobia and snake phobia. A sample of 13 BII phobia participants, 12 snake phobia individuals and 14 non-phobic controls underwent an S1-S2 task, where S1 was a word that described the content of a subsequent picture (blood-related, snake and neutral) that appeared 2 seconds later (S2). We obtained the P200 and P300 ERP amplitudes provoked by the pictures. Our results reveal that P200 did not differentiate between picture contents in BII phobia while, in contrast, snake and blood-related pictures provoked the largest responses in snake phobia participants. Both blood-related and snake pictures provoked greater P300 amplitudes than neutral pictures in all the groups. Threat cues reduced the electrocortical reaction of the BII, possibly by the elicitation of anticipatory or regulatory responses. These results are indicative of a low automatic, exogenous attention towards the feared stimuli in BII phobia, as revealed by P200, probably related to a lack of attentional bias to the phobic object.
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
Authors: Tindle Courtney , Fuller MacKenzie , Fonseca Ayden , Taheri Sahar , Ibeawuchi Stella-Rita , Beutler Nathan , Katkar Gajanan Dattatray , Claire Amanraj , Castillo Vanessa , Hernandez Moises , Russo Hana , Duran Jason , Crotty Alexander Laura E , Tipps Ann , Lin Grace , Thistlethwaite Patricia A , Chattopadhyay Ranajoy , Rogers Thomas F , Sahoo Debashis , Ghosh Pradipta , Das Soumita 
Published: August 2021

Background:SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear.Methods:We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from adult lung organoids (ALOs), primary airway cells, or hiPSC-derived alveolar type II (AT2) pneumocytes were infected with SARS-CoV-2 to create in vitro lung models of COVID-19.Results:Infected ALO monolayers best recapitulated the transcriptomic signatures in diverse cohorts of COVID-19 patient-derived respiratory samples. The airway (proximal) cells were critical for sustained viral infection, whereas distal alveolar differentiation (AT2→AT1) was critical for mounting the overzealous host immune response in fatal disease; ALO monolayers with well-mixed proximodistal airway components recapitulated both.Conclusions:Findings validate a human lung model of COVID-19, which can be immediately utilized to investigate COVID-19 pathogenesis and vet new therapies and vaccines.Funding:This work was supported by the National Institutes for Health (NIH) grants 1R01DK107585-01A1, 3R01DK107585-05S1 (to SD); R01-AI141630, CA100768 and CA160911 (to PG) and R01-AI 155696 (to PG, DS and SD); R00-CA151673 and R01-GM138385 (to DS), R01- HL32225 (to PT), UCOP-R00RG2642 (to SD and PG), UCOP-R01RG3780 (to P.G. and D.S) and a pilot award from the Sanford Stem Cell Clinical Center at UC San Diego Health (P.G, S.D, D.S). GDK was supported through The American Association of Immunologists Intersect Fellowship Program for Computational Scientists and Immunologists. L.C.A's salary was supported in part by the VA San Diego Healthcare System. This manuscript includes data generated at the UC San Diego Institute of Genomic Medicine (IGC) using an Illumina NovaSeq 6000 that was purchased with funding from a National Institutes of Health SIG grant (#S10 OD026929).
Screening and identification of NOTCH1, CDKN2A, and NOS3 as differentially expressed autophagy-related genes in erectile dysfunction
Authors: Luo Chao , Zhou Xiongcai , Wang Li , Zeng Qinyu , Fan Junhong , He Shuhua , Zhang Haibo , Wei Anyang 
Published: August 2021

Background
Loss of function of key autophagy genes are associated with a variety of diseases. However specific role of autophagy-related genes in erectile dysfunction ED remains unclear. This study explores the autophagy-related differentially expressed genes (ARGs) profiles and related molecular mechanisms in Corpus Cavernosum endothelial dysfunction, which is a leading cause of ED.

Methods
The Gene Expression Omnibus (GEO) database was used to identify the key genes and pathways. Differentially expressed genes (DEGs) were mined using the limma package in R language. Next, ARGs were obtained by matching DEGs and autophagy-related genes from GeneCard using Venn diagrams. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of ARGs were described using clusterProfiler and org.Hs.eg.db in R. Moreover, hub ARGs were screened out through protein-protein interaction (PPI), gene-microRNAs, and gene-transcription factors (TFs) networks then visualized using Cytoscape. Of note, the rat model of diabetic ED was established to validate some hub ARGs with qRT-PCR and Western blots.

Results
Twenty ARGs were identified from four ED samples and eight non-ED samples. GO analysis revealed that molecular functions (MF) of upregulated ARGs were mainly enriched in nuclear receptor activity. Also, MF of downregulated ARGs were mainly enriched in oxidoreductase activity, acting on NAD(P)H and heme proteins as acceptors. Moreover, six hub ARGs were identified by setting high degrees in the network. Additionally, hsa-mir-24-3p and hsa-mir-335-5p might play a central role in several ARGs regulation, and the transcription factors-hub genes network was centered with 13 ARGs. The experimental results further showed that the expression of Notch1, NOS3, and CDKN2A in the diabetic ED group was downregulated compared to the control.

Conclusions
Our study deepens the autophagy-related mechanistic understanding of endothelial dysfunction of ED. NOTCH1, CDKN2A, and NOS3 are involved in the regulation of endothelial dysfunction and may be potential therapeutic targets for ED by modulating autophagy.
Hypocholesterolemia and Statins in Multiple Myeloma
Authors: Yavaşoğlu Irfan , Turgutkaya Atakan 
Published: August 2021

Statins are lipid-lowering agents. They also have immunomodulatory, anti-inflammatory, anti-angiogenic, and anti-proliferative functions. In this context, they are demonstrated to have beneficial effects on mortality in several malignancies including esophageal, breast, lung, liver, pancreatic, endometrial, and colorectal cancers. Multiple myeloma is considered as an incurable plasma cell disorder with current therapy; however due to the current knowledge about the correlation between cholesterol-lowering agents and myeloma; it’s suggested to have lower mortality rates for patients using statins. Patients with multiple myeloma usually have a low cholesterol level which is often underestimated by clinicians. Hereby we aimed to summarize the myeloma-hypocholesterolemia relationship and emphasize the importance of statins as an inexpensive and beneficial approach for these patients.
Comparative Study of Children's' Blood Sugar in Fluid Therapy with Dextrose Saline, Ringer and Normal Saline 0.9% Serums and its Relationship with Depth of Anesthesia in Elective Surgery
Authors: Nanaei Farhad , Moghadam Morteza Habibi , Eslamifar Zahra , Bahrami Hadi , Bigdeli Mohammad Hasan , Sekhavatpour Zohreh 
Published: August 2021

Background: This study was aimed to determine the children's' blood sugar level in fluid therapy with DSS (dextrose saline serum), RS (ringer serum) and NS 0.9% serums (normal saline 0.9%) and its relationship with the depth of anesthesia in elective surgery.
Method: This double-blind experimental study was performed with 90 children referred to the surgical ward, including: group A (receiving DSS), group B (receiving NS 0.9%) and group C (receiving RS) that the blood sugar of each group in 5 steps was measured: half an hour before induction of anesthesia, during induction of anesthesia, half and one hour after induction of anesthesia and after complete awakening in recovery. In addition, the monitoring the vital signs, measuring depth of anesthesia, pulse oximetry and electrocardiogram were performed for all groups.
Results: The results showed that the mean blood sugar in the 5 steps measured had a significant difference in three groups under study (P <0.05). The mean blood sugar in the group receiving DSS was significantly higher than the two groups receiving RS and NS 0.9%. Also the mean depth of anesthesia in three groups did not show a significant difference.
Conclusion: Finally, according to this study, the use of DSS from the beginning of anesthesia, RS half an hour after the start of anesthesia and NS 0.9% one hour after the start of anesthesia can increase blood sugar in children. Therefore, the use of DSS is not recommended due to the stressful nature of anesthesia and operating room and the possibility of hyperglycemia.
To Assess the Physical Morbidity Profile among the Welders
Authors: Wanjari Mayur Bhaskarrao , Wankhede Pratibha 
Published: August 2021

Introduction: The welding profession poses many health hazards that the welders are exposed to everyday during working time. This leads to a large number of health consequences and diseases. Worldwide 10 million employees are exposed to iron fumes. Most are exposed by inhaling welding fumes that have iron as their main component. Exposure to iron fumes in steel mills and iron/steel foundries is also significant.
Background: For welders it is most important to take safety measures during working time. Welders are exposed to various types of hazardous substances that can affect their health. Worldwide welder’s morbidity is in a large number of welders affected. We conducted a study to find the physical morbidity pattern of welders in the Wardha region.
Objective- To assess the physical morbidity profile among the welders, and associate the physical morbidity profile with selected demographical variables in Wardha, India.
Methods: A purposive sample was conducted among 100 welders to identify the physical morbidity among welders. Welding workshop in separated space outside and inside the city of Wardha.one way ANOVA and t-test used to estimate the degree of association between the physical morbidity profile and the selected demographic variables.
Results: All welders were having some type of physical morbidity. The most frequent issues with the welding workers are injury to the eyes and skin. Age of welding worker, educational qualification, experience of welding work, hours worked per day are in association with the physical morbidity among welders.
Conclusion: In this study, the physical morbidity pattern of welders is identified. 87% welders were identified with mild physical morbidity and 13% of welders with moderate physical morbidity. Need some training program for welders to do right and safety welding and certificated course for welders.
A Retrospective Drug Utilization Study on Psychiatric Illness in a Tertiary Care Teaching Hospital
Authors: Michelle I. Jerlin , Dhanushri E. , RAJ V. Nidhish , Syed Muhammad Aslam , Priyadharshini A. , Ahalya S. P. 
Published: August 2021

Psychiatric disorders are now widely recognized as a major contributor to the global burden of disease. It has been described that there is an increased risk of adverse effects when more than one psychotropic drug is prescribed. Knowledge of the pattern of utilization of drugs in the general population can be achieved through the conduct of drug utilization studies. The present study has therefore been conducted to observe the pattern of drug use in psychiatry patients in a tertiary care hospital.
Aim and Objective:
To assess the epidemiology of various psychiatric illnesses among the study population
To assess the Prescribing Pattern of drugs in Psychiatric Illness.
To assess the drug-drug interactions in the prescription using MICROMEDEX.
Methodology: A retrospective descriptive observational study was performed in a tertiary care hospital. A total of 100 prescriptions were collected from MRD.
Results: The study reported that 66% of patients were males and 34% were females. The average number of drugs and psychotropic drugs per prescription is six and four respectively. Around 61.98% of drugs in the prescription are psychotropic drugs, among that 40.17% of benzodiazepines are majorly used, followed by 34.27% of antipsychotics. Almost 95 prescriptions had a minimum of one drug-drug interaction.
The average number of psychotropics per prescription was higher than in studies. The average number of drugs per prescription was 5.84, which lead to polypharmacy.
Conclusion: Using WHO indicators prescription analysis was done and it showed some deviation from the standard value which can be improved. Polypharmacy was noted in this study. Most of the drug is prescribed in the brand name which should be avoided.
COVID-19: Diagnosis, Management and Response
Authors: Mhaske Ashwini Shalikrao , Chakole Swaroopa 
Published: August 2021

Background: COVID infection 2019 (COVID-19) is identified as a disease caused by Corona virus formally known as severe acute respiratory syndrome (SARS-CoV-2), which was first detected in Wuhan City, Hubei Province, China, amidst of an outbreak of respiratory sickness cases.
Summary: As there is no affirmed total course of treatment for the Novel Coronavirus, the best way to handle it is by playing it safe, its administration and early reaction. Segregation and disinfection go inseparably with regards to dealing with a COVID positive patient. In any case, the predetermined number of clinical office accessible is blocking the cycle of control and anticipation for a particularly number of infected patients.
Conclusion: As the pandemic is advancing, more examinations and exploration is needed to effectively deal with the spread of the novel Corona virus. Foundation improvement and arrangement of clinical office and gear is the preeminent prerequisite for early reaction and treatment.
Air pollutants–particulate matter (PM)2.5 with antenatal exposure leading to adverse obstetrical outcomes of low birth weight and preterm birth: A systematic review and meta-analysis
Authors: Altangerel Otgontuya , Jeng Cherng-Jye , Wu Trong-Neng , Wu Wen-Yih , Chan Te-Fu , Kwan Aij-Lie , Chuang Linus T. 
Published: August 2021

Introduction
Particulate matter (PM)2.5 exposure affects prenatal health and birth outcomes, including low birth weight (LBW) and preterm delivery (PTD).

Objective
To identify and explore PM2.5 exposure on adverse obstetrical effects, including preterm birth and LBW.

Methods
Four hundred and nine studies from 1982 to 2020 were identified in a search of PubMed, Embase, Scopus, Web of Science, and Science Direct. Of the 409 articles, 24 were identified as “qualitatively considered” and 7 were identified as “quantitively eligible” to be included in this meta-analysis. The pooled effect of PM2.5 exposure on LBW and PTD was calculated using a random effect model with significant heterogeneity. Seven studies were conducted in the meta-analysis, and the pooled effect of PM2.5 exposure on LBW and entire pregnancy was 1.033 (95% CI, 1.025–1.041) with significant high heterogeneity (I2 = 96.110, P = 0.000). The pooled effect of PM2.5 exposure on PTD and entire pregnancy was 1.024 (95% CI, 1.015–1.033) with significantly different low heterogeneity (I2 = 60.036, P = 0.082).

Discussion
Exposure to PM2.5 during pregnancy is significantly associated with the risk of LBW, and the risk of PTD is significantly different but consistently associated with PM2.5.

Conclusion
Globally, PM2.5 exposure is significantly associated with serious pregnancy and birth outcomes worldwide. The emerging risks to prenatal health suggest a need for the government to influence health policies to protect maternal and pediatric health.
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation
Authors: Guo Xingchen , Chen Sheng , Yu Weiwei , Chi Zhexu , Wang Zhen , Xu Ting , Zhang Jian , Jiang Danlu , Guo Yuxian , Fang Hui , Zhang Kailian , Li Mobai , Yang Dehang , Yu Qianzhou , Ye Qizhen , Wang Di , Zhang Xue , Wu Yingliang 
Published: August 2021

The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase‐1 activation and interleukin‐1β maturation and drives cell fate toward pyroptosis. However, the mechanism of NLRP3 inflammasome activation still remains elusive. Here we provide evidence that AKT regulates NLRP3 inflammasome activation. Upon NLRP3 activation, AKT activity is inhibited by second stimulus‐induced reactive oxygen species. In contrast, AKT activation leads to NLRP3 inhibition and improved mitochondrial fitness. Mechanistically, AKT induces the phosphorylation of the DDX3X (DEAD‐box helicase 3, X‐linked), a recently identified NLRP3 inflammasome component, and impairs the interaction between DDX3X and NLRP3. Furthermore, an AKT agonist reduces NLRP3‐dependent inflammation in two in vivo models of LPS‐induced sepsis and Alum‐induced peritonitis. Altogether, our study highlights an important role of AKT in controlling NLRP3 inflammasome activation.