bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological evaluation of the modified nano-amorphous phosphate calcium doped with citrate/poly-amino acid composite as a potential candidate for bone repair and reconstruction
Authors: Wang Xiaomei , Zhao Dechuan , Ren Haohao , Yan Yonggang , Li Shuyang 
Published: January 2021

AbstractLarge numbers of research works related to fabricating organic–inorganic composite materials have been carried out to mimic the natural structure of bone. In this study, a new modified n-ACP doped with citrate (n-ACP-cit)/poly (amino acids) (PAA) composite (n-ACP-cit/PAA) was synthesized by employing high bioactive n-ACP-cit and the biodegradable and biocompatible PAA copolymer. Its basic structure was characterized by X-ray diffraction spectroscopy, Fourier transformed infrared spectroscopy, and X-ray photoelectron spectroscopy. Moreover, the degradability, bioactivity, biocompatibility, and osteoconductivity of n-ACP-cit/PAA composite were evaluated in vitro and in vivo, using simulated body fluid (SBF) solution soaking test, mouse bone marrow mesenchymal stem cells proliferation and differentiation, morphological observation test, expression of genes associated with osteogenesis, and bone defect model repair test, respectively. The modified n-ACP-cit/PAA composite exhibited a much higher weight loss rate (36.01 wt.%) than that of PAA (23.99 wt.%) after immersing in SBF solution for 16 weeks and the pH values of local environment restored to neutral condition. Moreover, cells co-culturing with composites exhibited higher alkaline phosphatase activity, more calcium nodule-formation, and higher expression levels of osteogenic differentiation-related genes (Bmp-2, Colla I, OCN, OPN, and Runx-2) than that of PAA. Furthermore, the bone defect model repair test revealed that the composite could be intimately incorporated with the surrounding bone without causing any deleterious reaction and capable of guiding new bone formation. Together, these results indicated that the new modified bone repair n-ACP-cit/PAA composite material with specific characteristics may be designed for meeting diverse requirements from biomedical applications.
On the Prediction of Solar Cycles
Authors: Courtillot V. , Lopes F. , Le Mouël J. L. 
Published: January 2021

AbstractThis article deals with the prediction of the upcoming solar activity cycle, Solar Cycle 25. We propose that astronomical ephemeris, specifically taken from the catalogs of aphelia of the four Jovian planets, could be drivers of variations in solar activity, represented by the series of sunspot numbers (SSN) from 1749 to 2020. We use singular spectrum analysis (SSA) to associate components with similar periods in the ephemeris and SSN. We determine the transfer function between the two data sets. We improve the match in successive steps: first with Jupiter only, then with the four Jovian planets and finally including commensurable periods of pairs and pairs of pairs of the Jovian planets (following Mörth and Schlamminger in Planetary Motion, Sunspots and Climate, Solar-Terrestrial Influences on Weather and Climate, 193, 1979). The transfer function can be applied to the ephemeris to predict future cycles. We test this with success using the “hindcast prediction” of Solar Cycles 21 to 24, using only data preceding these cycles, and by analyzing separately two 130 and 140 year-long halves of the original series. We conclude with a prediction of Solar Cycle 25 that can be compared to a dozen predictions by other authors: the maximum would occur in 2026.2 (± 1 yr) and reach an amplitude of 97.6 (± 7.8), similar to that of Solar Cycle 24, therefore sketching a new “Modern minimum”, following the Dalton and Gleissberg minima.
Distribution of environmental performance in life cycle assessments—implications for environmental benchmarking
Authors: Welling Sebastian , Ryding Sven-Olof 
Published: January 2021

Abstract
Purpose
Life cycle assessment (LCA) is considered a robust method to analyse the environmental impacts of products and is used in public and private market applications such as Green Public Procurement (GPP) and Environmental Management Systems (EMS). Despite the usefulness of the methodology, difficulties exist with the interpretation of LCA results. The use of benchmarks can facilitate this process, but there is yet little research on the definition of environmental benchmarks. The aim of this paper is to analyse the distribution of environmental performance used for the definition of the benchmark and how it effects the use in selected product categories.

Method
LCA results from 54 Environmental Product Declarations (EPDs) for insulation materials and 49 EPDs for bakery products are tested for their distribution. The outcome from the statistical analysis is used to compare and evaluate three calculation methods for a benchmark.

Results and discussion
The results of the study show that distributions and mid- and end-points of environmental performances of the studied indicators differ significantly for the two product categories. While some indicators for bakery products were closer to a normal distribution, most of the indicators are not normally distributed. This is reflected in the comparison of the chosen calculation methods for a benchmark, which showed that the distribution of the data affects the classification of the benchmark as well as the position of values on the benchmark.

Conclusion
The results emphasise that analysis of further product groups and the associated distribution of the environmental performance is needed to understand the implications of calculation methods on a benchmark. The availability of comparatively large datasets in a common structure is crucial for these analyses and can be facilitated through the digitalisation of LCA- and EPD-information. Furthermore, more research is needed on the communication formats for different benchmarking options, which must be applied for the different intended audiences to be effective.
Intracorporeal anastomosis in right hemicolectomy for colon cancer: short-term outcomes with the DaVinci Xi robot
Authors: Rattenborg Søren , Bundgaard Lars , Andersen Jesper , Lindebjerg Jan , Kuhn Jacob , Jakobsen Conny J. , Rahr Hans B. 
Published: January 2021

AbstractIntracorporeal anastomosis (IA) may improve outcomes compared with extracorporeal anastomosis (EA) in minimally invasive right colectomy. This is a prospective series of robotic right hemicolectomies (RRC) with IA from one institution. 35 consecutive patients with verified or suspected right colon cancer undergoing RRC with IA, and historic control groups of 22 RRC and 40 laparoscopic right colectomies (LRC), both with EA. Primary outcome measure was length of stay (LOS). Secondary outcome measures were 30-day complication rates, readmissions, pain scores, analgesic consumption, and specimen quality. Median LOS did not differ significantly between the groups (RRC-IA, 4 days; LRC-EA, 4 days; RRC-EA, 5 days). In-hospital surgical complications Clavien–Dindo 3 + were seen in 1, 2, and 0 patients, respectively, and 3, 5, and 3 patients were readmitted to hospital within 30 days. Median pain score was 2 in all groups on postoperative day (POD) 2. Relatively more patients in the RRC-IA group received gabapentin on POD 2 (p = 0.006), but use of other analgetics did not differ between groups. Mean specimen lengths were 31, 25 and 27 cm, respectively (RRC-IA vs. LRC-EA, p = 0.003), but mesentery width, proportion of mesocolic excisions and number of lymph nodes did not differ between the groups. RRC-IA was not associated with shorter LOS, fewer complications or better specimen quality than recent controls undergoing either RRC-EA or LRC-EA.
Students’ suspension of sense making in problem solving
Authors: Carotenuto Gemma , Di Martino Pietro , Lemmi Marta 
Published: January 2021

AbstractResearch on mathematical problem solving has a long tradition: retracing its fascinating story sheds light on its intricacies and, therefore, on its needs. When we analyze this impressive literature, a critical issue emerges clearly, namely, the presence of words and expressions having many and sometimes opposite meanings. Significant examples are the terms ‘realistic’ and ‘modeling’ associated with word problems in school. Understanding how these terms are used is important in research, because this issue relates to the design of several studies and to the interpretation of a large number of phenomena, such as the well-known phenomenon of students’ suspension of sense making when they solve mathematical problems. In order to deepen our understanding of this phenomenon, we describe a large empirical and qualitative study focused on the effects of variations in the presentation (text, picture, format) of word problems on students’ approaches to these problems. The results of our study show that the phenomenon of suspension of sense making is more precisely a phenomenon of activation of alternative kinds of sense making: the different kinds of active sense making appear to be strongly affected by the presentation of the word problem.
Cardiomyocyte Death and Genome-Edited Stem Cell Therapy for Ischemic Heart Disease
Authors: Cho Hyun-Min , Cho Je-Yoel 
Published: January 2021

AbstractMassive death of cardiomyocytes is a major feature of cardiovascular diseases. Since the regenerative capacity of cardiomyocytes is limited, the regulation of their death has been receiving great attention. The cell death of cardiomyocytes is a complex mechanism that has not yet been clarified, and it is known to appear in various forms such as apoptosis, necrosis, etc. In ischemic heart disease, the apoptosis and necrosis of cardiomyocytes appear in two types of programmed forms (intrinsic and extrinsic pathways) and they account for a large portion of cell death. To repair damaged cardiomyocytes, diverse stem cell therapies have been attempted. However, despite the many positive effects, the low engraftment and survival rates have clearly limited the application of stem cells in clinical therapy. To solve these challenges, the introduction of the desired genes in stem cells can be used to enhance their capacity and improve their therapeutic efficiency. Moreover, as genome engineering technologies have advanced significantly, safer and more stable delivery of target genes and more accurate deletion of genes have become possible, which facilitates the genetic modification of stem cells. Accordingly, stem cell therapy for damaged cardiac tissue is expected to further improve. This review describes myocardial cell death, stem cell therapy for cardiac repair, and genome-editing technologies. In addition, we introduce recent stem cell therapies that incorporate genome-editing technologies in the myocardial infarction model.
Cerebrovascular Autoregulation Monitoring in the Management of Adult Severe Traumatic Brain Injury: A Delphi Consensus of Clinicians
Authors: Depreitere B. , Citerio G. , Smith M. , Adelson P. David , Aries M. J. , Bleck T. P. , Bouzat P. , Chesnut R. , De Sloovere V. , Diringer M. , Dureanteau J. , Ercole A. , Hawryluk G. , Hawthorne C. , Helbok R. , Klein S. P. , Neumann J. O. , Robba C. , Steiner L. , Stocchetti N. , Taccone F. S. , Valadka A. , Wolf S. , Zeiler F. A. , Meyfroidt G. 
Published: January 2021

Abstract
Background
Several methods have been proposed to measure cerebrovascular autoregulation (CA) in traumatic brain injury (TBI), but the lack of a gold standard and the absence of prospective clinical data on risks, impact on care and outcomes of implementation of CA-guided management lead to uncertainty.

Aim
To formulate statements using a Delphi consensus approach employing a group of expert clinicians, that reflect current knowledge of CA, aspects that can be implemented in TBI management and CA research priorities.

Methods
A group of 25 international academic experts with clinical expertise in the management of adult severe TBI patients participated in this consensus process. Seventy-seven statements and multiple-choice questions were submitted to the group in two online surveys, followed by a face-to-face meeting and a third online survey. Participants received feedback on average scores and the rationale for resubmission or rephrasing of statements. Consensus on a statement was defined as agreement of more than 75% of participants.

Results
Consensus amongst participants was achieved on the importance of CA status in adult severe TBI pathophysiology, the dynamic non-binary nature of CA impairment, its association with outcome and the inadvisability of employing universal and absolute cerebral perfusion pressure targets. Consensus could not be reached on the accuracy, reliability and validation of any current CA assessment method. There was also no consensus on how to implement CA information in clinical management protocols, reflecting insufficient clinical evidence.

Conclusion
The Delphi process resulted in 25 consensus statements addressing the pathophysiology of impaired CA, and its impact on cerebral perfusion pressure targets and outcome. A research agenda was proposed emphasizing the need for better validated CA assessment methods as well as the focused investigation of the application of CA-guided management in clinical care using prospective safety, feasibility and efficacy studies.
Elucidating Methods for Isolation and Quantification of Exosomes: A Review
Authors: Kurian Talitha Keren , Banik Soumyabrata , Gopal Dharshini , Chakrabarti Shweta , Mazumder Nirmal 
Published: January 2021

AbstractExosomes are the smallest extracellular vesicles present in most of the biological fluids. They are found to play an important role in cell signaling, immune response, tumor metastasis, etc. Studies have shown that these vesicles also have diagnostic and therapeutic roles for which their accurate detection and quantification is essential. Due to the complexity in size and structure of exosomes, even the gold standard methods face challenges. This comprehensive review discusses the various standard methods such as ultracentrifugation, ultrafiltration, size-exclusion chromatography, precipitation, immunoaffinity, and microfluidic technologies for the isolation of exosomes. The principle of isolation of each method is described, as well as their specific advantages and disadvantages. Quantification of exosomes by nanoparticle tracking analysis, flow cytometry, tunable resistive pulse sensing, electron microscopy, dynamic light scattering, and microfluidic devices are also described, along with the applications of exosomes in various biomedical domains.
‘Strangely Like a Person’: Cole and the Queering of Asexuality in Dragon Age: Inquisition
Authors: Brown Melissa Shani , Partridge Nichola Lucy 
Published: January 2021

AbstractIn this article we consider the representation of the character Cole in Bioware’s Dragon Age: Inquisition (Electronic Arts, San Mateo, 2014), focusing upon how his asexuality is treated by other characters and its significance within his narrative arc. As well as contributing to the discussion of the representation of sexualities and gender within games, we seek to add to the ‘representational archive of asexuality’ (Cerankowski and Milks, Asexualities: Feminist and Queer Perspectives, Routledge, Abingdon, p 40, 2014), including games as media depicting and defining asexuality through fictional characterisation. We argue that it is particularly through humour that Cole is marked as being ambiguously set apart from the other characters in the game, and is infantilized as a ‘boy’ rather than a young man. Within a party of diverse genders, sexualities and indeed species, Cole’s absent interest in sex is treated as though it were something strange and in need of being overcome for Cole to become fully ‘human’. Beyond the scope of this game, this raises further questions for the representation of asexuality within media culture, and broader cultural discourses concerning whether asexuality is conceived of as being within the bounds of both masculinity and human normality.
Clinical practice guidelines for high-resolution breast PET, 2019 edition
Authors: Satoh Yoko , Kawamoto Masami , Kubota Kazunori , Murakami Koji , Hosono Makoto , Senda Michio , Sasaki Masayuki , Momose Toshimitsu , Ito Kengo , Okamura Terue , Oda Keiichi , Kuge Yuji , Sakurai Minoru , Tateishi Ukihide , Fujibayashi Yasuhisa , Magata Yasuhiro , Yoshida Takeshi , Waki Atsuo , Kato Katsuhiko , Hashimoto Teisuke , Uchiyama Mayuki , Kinuya Seigo , Higashi Tatsuya , Magata Yasuhiro , Machitori Akihiro , Maruno Hirotaka , Minamimoto Ryogo , Yoshinaga Keiichiro 
Published: January 2021

AbstractBreast positron emission tomography (PET) has had insurance coverage when performed with conventional whole-body PET in Japan since 2013. Together with whole-body PET, accurate examination of breast cancer and diagnosis of metastatic disease are possible, and are expected to contribute significantly to its treatment planning. To facilitate a safer, smoother, and more appropriate examination, the Japanese Society of Nuclear Medicine published the first edition of practice guidelines for high-resolution breast PET in 2013. Subsequently, new types of breast PET have been developed and their clinical usefulness clarified. Therefore, the guidelines for breast PET were revised in 2019. This article updates readers as to what is new in the second edition. This edition supports two different types of breast PET depending on the placement of the detector: the opposite-type (positron emission mammography; PEM) and the ring-shaped type (dedicated breast PET; dbPET), providing an overview of these scanners and appropriate imaging methods, their clinical applications, and future prospects. The name “dedicated breast PET” from the first edition is widely used to refer to ring-shaped type breast PET. In this edition, “breast PET” has been defined as a term that refers to both opposite- and ring-shaped devices. Up-to-date breast PET practice guidelines would help provide useful information for evidence-based breast imaging.
The Design Model for Robotic Waitress
Authors: Yang Jiaji , Chew Esyin 
Published: January 2021

AbstractWith the rapid development of traditional industries, intelligent robots have been widely used in the hospitality industry. Although the development of intelligent robots faces a positive trend and a good market in the hospitality industry, it also faces the problem that robots cannot effectively collect and use user data in the field of human–computer interaction. It not only affects the interaction experience between users and robots, but also prevents companies from getting valuable feedback in a timely manner. In order for intelligent robots to effectively utilize interactive information, the user experience of robot entertainment is improved. This paper proposes and establishes a basic technical model called iRCXM. Combining the iRCXM model with a decision tree classification algorithm is excepted effectively improve the interaction experience between humans and robots in hospitality. This paper designs a model of intelligent robot based on decision tree algorithm. The model divides the user into three sections, each corresponding to a different standard function. Using a decision tree classification algorithm model is excepted effectively judge users’ current stage and whether they can move to the next stage. When the user reaches the final stage, it proves that the user has obtained a good interactive experience. At the same time, for users at different stages, the model will provide strategies for downward transformation so that companies can adjust and improve existing problems in a timely manner. In addition, the research developed a robot user interaction system based on the existing technology. The system is based on Android. Using HTTP protocol and Baidu Cloud AI API to realize simple face recognition and Sanbot-OpenSDK to implement simple robot control, the development of this system is to verify the feasibility of the model. The developed samples were tested in a real environment and feedback from customer experience was collected through semi-structured interviews. Finally, the feasibility of the model is verified.
The Möbius strip of market spatiality: mobilizing transdisciplinary dialogues between CCT and the marketing mainstream
Authors: Coffin Jack , Chatzidakis Andreas 
Published: January 2021

AbstractThis paper develops the Möbius strip as an ‘ordering theory’ (Sandberg and Alvesson, 2020) that brings CCT studies into dialogue with mainstream marketing approaches. The aim is to work toward a transdisciplinary understanding of market spatiality, a topic that has become increasingly important for theorists and practitioners (Warnaby and Medway, 2013; Castilhos et al., 2016; Chatzidakis et al., 2018). Building on psychosocial interpretations of the Möbius strip as a ‘tactical’ way of thinking, a range of insights and ideas are organized along a single strip of theorization. This paper maps a continuous plane of logic between the concepts of space, place, emplacement, spatiality, implacement, and displacement. The potential applications of the Möbius strip are then demonstrated by showing how the transdisciplinary topic of ‘atmosphere’ can be theorized from multiple perspectives. The paper concludes by exploring how the Möbius strip might also be employed in other areas of marketing theory and practice, potentially generating further transdisciplinary conversations between CCT and the marketing mainstream.
Combined support mechanism of rock bolts and anchor cables for adjacent roadways in the external staggered split-level panel layout
Authors: Batugin Adrian , Wang Zhiqiang , Su Zehua , Sidikovna Shermatova Sayyora 
Published: January 2021

AbstractUsing the spatial structure of the external staggered split-level panel layout, a combined support technology for adjacent roadways was developed and analyzed for a rock bolt and anchor cable mechanism. The influence of the side rock bolt and anchor cable parameters on the mechanical properties of the anchorage body and the support stress distribution of the lateral coal body were revealed using the FLAC3D software. The optimal support parameters of the side rock bolts and anchor cables were subsequently determined, and the support effect of gob-side entry in a mining scenario was verified. The results show that the support of the side rock bolts and anchor cables improves the mechanical properties and stress state of the anchorage body, producing a good protective effect on the coal body of the air-intake entry roof and side wall. This is beneficial to the stability of the side wall and the realization of the suspension effect for roof rock bolts and anchor cables, which in turn makes the surrounding rock maintenance of the gob-side entry to a thick coal seam more favorable.
Spontaneous Dramatization as Dialogical Space in the School Context
Authors: Pascarella Federica , Vicigrado Antonietta , Tateo Luca , Marsico Giuseppina 
Published: January 2021

AbstractThe use of dramatization as teaching/learning methodology, useful for the improvement of social, emotional, creative skills, and for the acquisition of knowledge on subject matters such as history, is an established field of research and practice. Yet, there are very few studies on children’s spontaneous dramatization in educational context and its potential role in development. The term dramatization, as we will use here, refers to the human activity of staging in narrative and ritualistic form, enacted through the whole person and multiple channels, communicative and self-presentation meanings. The school context is a privileged arena to observe spontaneous dramatization between peers and between children and adults. Besides, school everyday routine is often filled with staged dramatizations aimed for instance at building collective identity or providing moral orientation. We propose a new theoretical framework and analyse field observation in kindergarten and primary school to interpret spontaneous dramatization and collective school routines.