bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacunas en el derecho a la salud.
Authors: Olivera Diaz Álvaro 
Published: October 2021

Para las actuales generaciones del planeta la presente pandemia es algo inédito, salvo excepciones. Antaño, como hoy, prevalece el interés primario de la ciencia centrado en el bienestar humano; aunque las investigaciones conducentes a innovación y desarrollo de vacunas estén mediadas por intereses comerciales; lo relevante es la financiación de las multinacionales farmacéuticas que lo hacen posible, porque los presupuestos oficiales para investigación académica son limitados frente a las exigencias económicas y costos de los ensayos clínicos, método que valida la evidencia científica con el rigor que lo fundamenta y sustenta. Declarada la pandemia, hasta ahora incontrolable, las investigaciones en los campos de diagnóstico, prevención y terapéuticos son permanentes. Y por supuesto, las expectativas de la gente que reclama derechos a la salud y a la asistencia sanitaria. El primero, en el sentido de no ser sujetos de la acción lesiva de otros, incluido el Estado. El segundo, consistente en el derecho positivo estipulado en normas como la Ley Estatutaria en salud de 2015 en Colombia, que consagra instrumentos jurídicos para garantizarlo. En ese escenario existen preocupaciones porque el orden internacional privilegia el poder de las naciones desarrolladas, que deriva en riesgos éticos para distribuir las vacunas cuando se adolece de inequidad, a sabiendas de la declaración de los derechos humanos universales que conlleva interpretaciones y trasfondos de obviedad, por lo que recientemente el director de la Organización Mundial de la Salud (OMS) ha advertido sobre el fracaso moral en que subyace el abismo de la inequidad.
Granuloma piógeno gigante : reporte de caso.
Authors: Orozco Sebá Beatríz Elena , Meléndez Ramírez Esperanza , Rodríguez Safi Juan Sebastián , Maraby Martínez Samia Zulema 
Published: October 2021

Introducción: el granuloma piógeno es un tumor vascular benigno de la piel o de membranas mucosas que se produce probablemente debido a una respuesta hiperplásica reactiva a un estímulo angiogénico desequilibrado. Clínicamente suelen ser pápulas solitarias que suelen crecer con rapidez hacia un tumor pediculado de superficie ulcerada y sangrantes en el transcurso de semanas a meses, el tamaño puede variar desde milímetros hasta unos centímetros en las lesiones más grandes. Es muy raro que adquiera un tamaño mayor de 1 centímetro y puede persistir indefinidamente si no se extirpa. Caso clínico: paciente femenina de 29 años de edad que presentaba lesión tumoral pediculada color parduzco de aproximadamente 2 meses de evolución con rápido crecimiento. Inició con una pápula eritematosa asintomática que posteriormente se torna dolorosa, sin antecedente de trauma previo. Al examen físico se apreciaba lesión tumoral lobulada, con zonas ulceradas y fragilidad capilar. Se llevó a cabo la extirpación de la lesión y esta fue enviada a patología, reportando que los hallazgos microscópicos eran concordantes con un hemangioma lobular capilar. En el control realizado cuarenta y cinco días después de la resección no se encontró recidiva de la lesión. Conclusión: el granuloma piógeno es una lesión tumoral benigna que es relativamente frecuente, sin embargo, el granuloma piógeno gigante es rara de observar, ya que estas lesiones con poca frecuencia sobrepasan 1 centímetro de diámetro. Su tratamiento por lo general es la resección quirúrgica, acompañada también de la evasión de factores que puedan provocar su recurrencia.
Estado actual del consumo de alcohol en una institución de educación superior en estudiantes universitarios durante el 2017 en Bogotá
Authors: Buriticá Quinceno María Johana , Ramírez Ayde Lorena 
Published: October 2021

Considerando que el alcohol es la primera sustancia psicoactiva de uso lícito que causa mayor morbilidad y mortalidad debido al alto nivel de dependencia. Los universitarios caracterizan por manifestaciones de independencia y deseos de experimentar nuevos comportamientos como “adultos” que pueden llegar a ser promotores para del consumo de alcohol. El consumo de alcohol es un problema de salud pública en especial identificado en los universitarios de acuerdo al estudio de: consumo de alcohol en universitarios en el 2005 de la Universidad Católica de Colombia. Describir el consumo de alcohol en una institución de educación superior en estudiantes universitarios durante el 2017 en Bogotá. El estudio es de corte descriptivo–transversal con una muestra de estudiantes universitarios, obtenida por muestreo aleatorio estratificado con una muestra de 3360 estudiantes distribuidos por facultades y programas. Para la recolección de datos se aplicó un cuestionario para caracterizar el consumo de alcohol y los factores sociodemográficos y se aplicó el test de AUDIT, para medir el consumo de alcohol. El análisis de la información incluyó estadísticos descriptivos de las características sociodemográficos y patrones de consumo sin asociaciones de variables. Se encontró una prevalencia de consumo de alcohol de 62,8 %, la mayoría de estudiantes reportan consumir alcohol con su grupo de amigos (49,6 %), La frecuencia de consumo de alcohol se da principalmente cada mes (62 %) y frente al sexo, las mujeres son quienes mayor consumen con un (68,5 %), la edad de inicio de consumo alcohol se sitúa a los 15 años. Los niveles de consumo de alcohol en la comunidad universitaria se encuentran por encima del 50 % y es necesario que las universidades desarrollen acciones de control diferenciales.
Всихання клена гостролистого (Acer platanoides L.) в Україні та причини погіршення його стану в Харківській області
Authors: Ustsky I. M. , Mikhaylichenko O. A. , Zhadan I. V. 
Published: October 2021

Розвиток патологічних процесів у насадженнях клена гостролистого (Acer platanoides L.) за період 1994–2018 рр. викликаний кліматичними змінами. Наслідком цих змін є хвороби, площа осередків яких суттєво збільшилася починаючи з 2009 р. і станом на 2018 р. досягли максимуму. Основною причиною всихання клена у Харківській області є відхилення від норми кліматичних показників періоду кінця 2015 та початку 2016 років. Цей період характеризувався посухою у серпні – жовтні 2015 р. (22 мм опадів) та перевищенням середніх багаторічних показників температури та опадів (у 3 та 2 рази відповідно) у листопаді. Тривале зниження температури наприкінці грудня спричинило обмерзання пагонів, а потепління в третій декаді лютого 2016 р. було перерване зниженням температури до -4°С, під час якого обмерзали бруньки та пагони, коли вже почався сокорух. Найбільшу втрату крон (до 90 %) мали насадження на важкосуглинистих чорноземах. На ґрунтах із легшим механічним складом рівень дефоліації був суттєво меншим.
The role of intellectual property in security defense capacity of the state
Authors: Zaikivskyi Oleksandr , Onistrat Oleksandr 
Published: October 2021

Keywords: defense capability, intellectual property, regulatory support
The conceptual issues of the legislation of Ukraine,which determine the state policy in the field of national security and defence, regardingthe settlement of issues related to ensuring the state defence capabilities are considered.The scientific publications on actual questions in this sphere concerningproblems and prospects of increase of defence capability of Ukraine are analysed.The role of intellectual property in all components of Ukraine's defence system hasbeen studied, and it has been noted that unresolved problems in the field of intellectualproperty management pose an increasing threat to Ukraine's national security.The importance of ensuring the protection of intellectual property in the process ofimplementing measures to improve the defence capabilities of the state and the needto improve legislation in this area is defined.Recommendations for improving the regulatory framework for national securityand defence in order to address the problematic issues of intellectual property in thisarea are submitted.State defence capability is the ability of state to defend itself in the event of armedaggression or armed conflict. It consists of material and immaterial elements and is aset of military, economic, social and moral and political potential in the field of defenceand appropriate conditions for its implementation.Resolving the issues of reforming not only the Armed Forces of Ukraine, but firstthe entire state, modernization and rearmament of the Ukrainian army has become avital necessity. Only the solution of this issue will allow to raise the defence capabilityof our state to the proper level for the preservation of independent Ukraine.Ensuring the military security of Ukraine largely depends on equipping the ArmedForces of Ukraine with modern types and models of weapons and military equipment,developed on the basis of intellectual property rights.It is the military-technical sphere where the objects of intellectual property rightsbelonging to the sphere of national security and defence are created, and the state isobliged to ensure their protection. This will increase the competitiveness of the domesticdefence industry and make claims impossible for anyone in the mass productionof weapons and military equipment for their own needs and for exports, which directlyaffects defence capabilities.And this requires proper protection of intellectual property rights both in theprocess of own production of weapons and military equipment, as well as in militarytechnicalcooperation.
External Counterpulsation Improves Angiogenesis by Preserving Vascular Endothelial Growth Factor-A and Vascular Endothelial Growth Factor Receptor-2 but Not Regulating MicroRNA-92a Expression in Patients With Refractory Angina
Authors: Ambari Ade Meidian , Lilihata Gracia , Zuhri Ervan , Ekawati Elok , Wijaya Shoma Adhi , Dwiputra Bambang , Sukmawan Renan , Radi Basuni , Haryana Sofia Mubarika , Adiarto Suko , Hanafy Dicky A. , Zamroni Dian , Elen Elen , Mangkuanom Arwin S. , Santoso Anwar 
Published: October 2021

Objective: External counterpulsation (ECP) provides long-term benefits of improved anginal frequency and exercise tolerance in patients with refractory angina (RA). This is postulated as a result of improved angiogenesis and endothelial function through an increase in shear stress. Angiogenesis is mainly represented by vascular endothelial growth factor-A (VEGF-A) and its receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). The microRNA-92a (miR-92a) is a flow-sensitive miRNA that regulates atherosclerosis and angiogenesis in response to shear stress. Thus, ECP beneficial effect might be achieved through interaction between VEGF-A, VEGFR-2, and miR-92a. This study aims to evaluate the ECP effect on VEGF-A, VEGFR-2, and miR-92a in patients with RA in a sham-controlled manner.Methods: This was a randomized sham-controlled trial, enrolling 50 patients with RA who have coronary artery disease (CAD). Participants were randomized (1:1 ratio) to 35 sessions of either ECP (n = 25) or sham (n = 25), each session lasting for 1 h. Plasma levels of VEGF-A and VEGFR-2 were assayed by the ELISA technique. The quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to measure miR-92a circulating levels in plasma.Result: External counterpulsation significantly preserved VEGF-A and VEGFR-2 level compared to sham [ΔVEGF-A: 1 (−139 to 160) vs.−136 (−237 to 67) pg/ml, p = 0.026; ΔVEGFR-2: −171(-844 to +1,166) vs. −517(−1,549 to +1,407) pg/ml, p = 0.021, respectively]. Circulating miR-92a increased significantly in ECP [5.1 (4.2–6.4) to 5.9 (4.8–6.4), p &lt; 0.001] and sham [5.2 (4.1–9.4) to 5.6 (4.8–6.3), p = 0.008] post-intervention. The fold changes tended to be higher in ECP group, although was not statistically different from sham [fold changes ECP = 4.6 (0.3–36.5) vs. sham 2.8 (0–15), p = 0.33)].Conclusion: External counterpulsation improved angiogenesis by preserving VEGF-A and VEGFR-2 levels. Both ECP and sham increased miR-92a significantly, yet the changes were not different between the two groups. (Study registered on www.clinicaltrials.gov, no: NCT03991871, August 8, 2019, and received a grant from the National Health Research and Development of Ministry of Health of Indonesia, No: HK.02.02/I/27/2020).
Environmental Risk Factors for Endometriosis: An Umbrella Review of a Meta-Analysis of 354 Observational Studies With Over 5 Million Populations
Authors: Zhang Ye , Ma Ning-Ye 
Published: October 2021

Background: The association between a diverse array of environmental risk factors and the risk of endometriosis is contradictory.Objective: To summarize the evidence of associations between environmental risk factors and the risk of endometriosis.Methods: Databases such as PubMed, EMBASE, Web of Science, and ClinicalTrial.gov were systematically searched in June 2020. Meta-analyses of observational studies investigated any environmental exposure (non-genetic) and endometriosis risk. For each article, we estimated the summary effect size, 95% CIs, and the 95% prediction interval (PI). We also estimated the between-study heterogeneity expressed by I2, evidence for small-study effects, and evidence of excess significance bias.Results: About 12 eligible articles (featuring 143,422 cases and 5,112,967 participants) yielded data on 40 unique environmental risk factors, including life styles (n = 16), reproductive factors (n = 3), early life factors (n = 4), and a range of other risk factors [e.g., phthalate metabolites, endocrine-disrupting chemicals, and body mass index (BMI)]. About 25 of these 40 associations (62.5%) were statistically significant (p &lt; 0.05) under random-effects models. Evidence for an association was indicated for alcohol intake [relative risk (RR): 1.25; 95% CI: 1.11–1.41] and the exposure to endocrine disruptor chemicals (EDCs) (RR: 1.41; 95% CI: 1.23–1.60) while 15 associations presented only weak evidence.Conclusions: Our analyses showed that alcohol intake and exposure to endocrine-disrupting chemicals may be potential risk factors for endometriosis and supported by suggestive epidemiological evidence. However, it was evident that there was substantial heterogeneity and/or bias between the different studies featured in various meta-analyses included in this review; therefore, the outcomes of our analysis should be interpreted cautiously.
Identification of Five Quality Needs for Rheumatology (Text Analysis and Literature Review)
Authors: Pallua Johannes , Schirmer Michael 
Published: October 2021

Background: While the use of the term “quality” in industry relates to the basic idea of making processes measurable and standardizing processes, medicine focuses on achieving health goals that go far beyond the mere implementation of diagnostic and therapeutic processes. However, the quality management systems used are often simple, self-created concepts that concentrate on administrative processes without considering the quality of the results, which is essential for the patient. For several rheumatic diseases, both outcome and treatment goals have been defined. This work summarizes current mainstreams of strategies with published quality efforts in rheumatology.Methods: PubMed, Cochrane Library, and Web of Science were used to search for studies, and additional manual searches were carried out. Screening and content evaluation were carried out using the PRISMA-P 2015 checklist. After duplicate search in the Endnote reference management software (version X9.1), the software Rayyan QCRI (https://rayyan.qcri.org) was applied to check for pre-defined inclusion and exclusion criteria. Abstracts and full texts were screened and rated using Voyant Tools (https://voyant-tools.org/). Key issues were identified using the collocate analysis.Results: The number of selected publications was small but specific (14 relevant correlations with coefficients &gt;0.8). Using trend analysis, 15 publications with relative frequency of keywords &gt;0.0125 were used for content analysis, revealing 5 quality needs. The treat to target (T2T) initiative was identified as fundamental paradigm. Outcome parameters required for T2T also allow quality assessments in routine clinical work. Quality care by multidisciplinary teams also focusing on polypharmacy and other quality aspects become essential, A global software platform to assess quality aspects is missing. Such an approach requires reporting of multiple outcome parameters according to evidence-based clinical guidelines and recommendations for the different rheumatic diseases. All health aspects defined by the WHO (physical, mental, and social health) have to be integrated into the management of rheumatic patients.Conclusion: For the future, quality projects need goals defined by T2T based initiatives in routine clinical work, secondary quality goals include multidisciplinary cooperation and reduction of polypharmacy. Quality indicators and standards in different health systems will provide new information to optimize patients' care in different health systems.
Computational Recognition and Clinical Verification of TGF-β-Derived miRNA Signature With Potential Implications in Prognosis and Immunotherapy of Intrahepatic Cholangiocarcinoma
Authors: Liu Zaoqu , Weng Siyuan , Xu Hui , Wang Libo , Liu Long , Zhang Yuyuan , Guo ChunGuang , Dang Qin , Xing Zhe , Lu Taoyuan , Han Xinwei 
Published: October 2021

MicroRNAs (miRNAs) were recently implicated in modifying the transforming growth factor β (TGF-β) signaling in multiple cancers. However, TGF-β-derived miRNAs and their potential clinical significance remain largely unexplored in intrahepatic cholangiocarcinoma (ICC). In this study, we proposed an integrated framework that enables the identification of TGF-β-derived miRNAs in ICC (termed “TGFmitor”). A total of 36 TGF-β-derived miRNAs were identified, of which nine significantly correlated with overall survival (OS) and aberrantly expressed in ICC. According to these miRNAs, we discovered and validated a TGF-β associated miRNA signature (TAMIS) in GSE53870 (n =63) and TCGA-CHOL (n =32). To further confirm the clinical interpretation of TAMIS, another validation based on qRT-PCR results from 181 ICC tissues was performed. TAMIS was proven to be an independent risk indicator for both OS and relapse-free survival (RFS). TAMIS also displayed robust performance in three cohorts, with satisfactory AUCs and C-index. Besides, patients with low TAMIS were characterized by superior levels of CD8+ T cells infiltration and PD-L1 expression, while patients with high TAMIS possessed enhanced CMTM6 expression. Kaplan-Meier analysis suggested CMTM6 could further stratify TAMIS. The TAMIShighCMTM6high subtype had the worst prognosis and lowest levels of CD8A and PD-L1 expression relative to the other subtypes, indicating this subtype might behave as “super-cold” tumors. Notably, the improved discrimination was observed when CMTM6 was combined with TAMIS. Overall, our signature could serve as a powerful tool to help improve prognostic management and immunotherapies of ICC patients.
Identification of Immune-Cell-Related Prognostic Biomarkers of Esophageal Squamous Cell Carcinoma Based on Tumor Microenvironment
Authors: Cui Yiyao , Hou Ruiqin , Lv Xiaoshuo , Wang Feng , Yu Zhaoyan , Cui Yong 
Published: October 2021

BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most fatal cancers in the world. The 5-year survival rate of ESCC is &lt;30%. However, few biomarkers can accurately predict the prognosis of patients with ESCC. We aimed to identify potential survival-associated biomarkers for ESCC to improve its poor prognosis.MethodsImmuneAI analysis was first used to access the immune cell abundance of ESCC. Then, ESTIMATE analysis was performed to explore the tumor microenvironment (TME), and differential analysis was used for the selection of immune-related differentially expressed genes (DEGs). Weighted gene coexpression network analysis (WGCNA) was used for selecting the candidate DEGs. Least absolute shrinkage and selection operator (LASSO) Cox regression was used to build the immune-cell-associated prognostic model (ICPM). Kaplan–Meier curve of survival analysis was performed to evaluate the efficacy of the ICPM.ResultsBased on the ESTIMATE and ImmuneAI analysis, we obtained 24 immune cells’ abundance. Next, we identified six coexpression module that was associated with the abundance. Then, LASSO regression models were constructed by selecting the genes in the module that is most relevant to immune cells. Two test dataset was used to testify the model, and we finally, obtained a seven-genes survival model that performed an excellent prognostic efficacy.ConclusionIn the current study, we filtered seven key genes that may be potential prognostic biomarkers of ESCC, and they may be used as new factors to improve the prognosis of cancer.
The Global Research Trends and Hotspots on Developmental Dysplasia of the Hip: A Bibliometric and Visualized Study
Authors: Wu Haiyang , Wang Yulin , Tong Linjian , Yan Hua , Sun Zhiming 
Published: October 2021

Background: Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder in newborns and also one of the most common causes of hip arthritis in women. Many topics concerning DDH still remain controversial, and the global research trend in this field has not been well-studied yet. The aim of the present study was to illustrate the overall knowledge structure, development trends, and research hotspots of DDH.Methods: The publications related to DDH from 1998 to 2020 were identified from the Web of Science Core Collection (WOSCC). Three bibliometric tools were used to conduct visualization and knowledge maps. Annual trends of publications, contributions of countries, institutions, authors, funding agencies and journals, and clustering of keywords were analyzed.Results: A total of 2,691 publications were included. The annual number of DDH publications showed an increasing trend worldwide. The United States has made the greatest contribution, with the largest number of publications and the highest H-index. The most prolific institutions were Shanghai Jiao Tong University, Children's Hospital of Philadelphia, and Shriners Hospital for Children. Professors Tönnis D, Harris WH, Crowe JF, Graf R, and Salter RB have made great achievements in this field. However, the collaboration between international institutions or researchers was relatively low and mainly conducted in European and American countries. All the keywords could be divided into five clusters: hip osteoarthritis study, hip replacement study, hip ultrasound study, osteotomy surgery study, and etiology study. A trend of balanced and diversified development existed in these clusters. Keywords with the ongoing bursts, including clinical outcome, risk factor, femoroacetabular impingement, predictor, arthroscopy, morphology, and anteversion may continue to be the research hotspots in the near future.Conclusions: There will be an increasing number of publications on DDH research, and the United States stay ahead in this field. International collaboration needs to be further strengthened. The information can provide helpful references for researchers to explore hot issues or target a specific field of DDH.