bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stenotic intercondylar notch is not a risk factor for posterior cruciate ligament rupture: a morphological analyses using magnetic resonance imaging
Authors: Liu Fei , Zhang Sheng , Xiao Yang , Feng Xiaoreng , Liang Zhenming , Leung Frankie , Chen Bin 
Published: September 2021

Abstract
Purpose
The present study aimed to examine the factors related to the morphological characteristics of the femoral condyle in posterior cruciate ligament rupture in female and male populations.

Methods
One hundred and three patients (41 females, 62 males) with posterior cruciate ligament rupture from 2010 to 2020 were included in this retrospective case–control study. The sex and age of the posterior cruciate ligament rupture group were matched to those of the control group (41 females, 62 males; age range 16–69 years). Magnetic resonance imaging was used to measure the intercondylar notch width, femoral condylar width, and intercondylar notch angle in both the axial and coronal images. The ‘α’ angle was also measured using magnetic resonance imaging. The notch width index is the ratio of the intercondylar notch width to the femoral condylar width. Three types of intercondylar notch shapes (types A, U, and W) were evaluated in the axial magnetic resonance imaging images.

Results
The difference in the mean coronal notch width index between the study groups was statistically significant in the female population. The difference in the mean coronal femoral condylar width between the study groups was statistically significant in the male population.

Conclusions
A larger coronal notch width index was the greatest risk factor for posterior cruciate ligament rupture in the female population. In the male population, decreased coronal condylar width was the greatest risk factor for posterior cruciate ligament rupture. The results did not indicate that patients with a PCL rupture have a stenotic intercondylar notch. Posterior cruciate ligament injury prevention strategies could be applied to females with a larger coronal notch width index and males with a decreased condylar width.

Levels of evidence
Level III.
Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo
Authors: Annibal Andrea , Ripa Roberto , Ballhysa Eugen , Latza Christian , Hochhard Nadine , Antebi Adam 
Published: September 2021

AbstractCyclic dinucleotides (CDNs) are key secondary messenger molecules produced by cyclic dinucleotide synthases that trigger various cellular signaling cascades from bacteria to vertebrates. In mammals, cyclic GMP-AMP synthase (cGAS) has been shown to bind to intracellular DNA and catalyze the production of the dinucleotide 2′3′ cGAMP, which signals downstream effectors to regulate immune function, interferon signaling, and the antiviral response. Despite the importance of CDNs, sensitive and accurate methods to measure their levels in vivo are lacking. Here, we report a novel LC-MS/MS method to quantify CDNs in vivo. We characterized the mass spectrometric behavior of four different biologically relevant CDNs (c-di-AMP, c-di-GMP, 3′3′ cGAMP, 2′3′ cGAMP) and provided a means of visually representing fragmentation resulting from collision-induced dissociation at different energies using collision energy breakdown graphs. We then validated the method and quantified CDNs in two in vivo systems, the bacteria Escherichia coli OP50 and the killifish Nothobranchius furzeri. We found that optimization of LC-MS/MS parameters is crucial to sensitivity and accuracy. These technical advances should help illuminate physiological and pathological roles of these CDNs in in vivo settings.
Technical and clinical validation of commercial automated volumetric MRI tools for dementia diagnosis—a systematic review
Authors: Pemberton Hugh G. , Zaki Lara A. M. , Goodkin Olivia , Das Ravi K. , Steketee Rebecca M. E. , Barkhof Frederik , Vernooij Meike W. 
Published: September 2021

AbstractDevelopments in neuroradiological MRI analysis offer promise in enhancing objectivity and consistency in dementia diagnosis through the use of quantitative volumetric reporting tools (QReports). Translation into clinical settings should follow a structured framework of development, including technical and clinical validation steps. However, published technical and clinical validation of the available commercial/proprietary tools is not always easy to find and pathways for successful integration into the clinical workflow are varied. The quantitative neuroradiology initiative (QNI) framework highlights six necessary steps for the development, validation and integration of quantitative tools in the clinic. In this paper, we reviewed the published evidence regarding regulatory-approved QReports for use in the memory clinic and to what extent this evidence fulfils the steps of the QNI framework. We summarize unbiased technical details of available products in order to increase the transparency of evidence and present the range of reporting tools on the market. Our intention is to assist neuroradiologists in making informed decisions regarding the adoption of these methods in the clinic. For the 17 products identified, 11 companies have published some form of technical validation on their methods, but only 4 have published clinical validation of their QReports in a dementia population. Upon systematically reviewing the published evidence for regulatory-approved QReports in dementia, we concluded that there is a significant evidence gap in the literature regarding clinical validation, workflow integration and in-use evaluation of these tools in dementia MRI diagnosis.
Prevalence of hypogammaglobulinemia and its management with subcutaneous immunoglobulin supplementation in patients after allogeneic hematopoietic stem cell transplantation—a single-center analysis
Authors: Karakulska-Prystupiuk Ewa , Dwilewicz-Trojaczek Jadwiga , Drozd-Sokołowska Joanna , Kmin Ewelina , Chlebus Marcin , Szczypińska Karolina , Boguradzki Piotr , Tomaszewska Agnieszka , Mądry Krzysztof , Biliński Jarosław , Basak Grzegorz Władysław , Jędrzejczak Wiesław Wiktor 
Published: September 2021

AbstractSecondary immunodeficiencies are frequently observed after allo-HSCT. The efficacy of subcutaneous IgG preparations in this population is unknown. A retrospective single-institution study involved 126 adult patients transplanted in 2012–2019 for hematological malignancies. Patients were tested every 2–3 weeks for plasma IgG concentration during the 1st year after transplantation and supplemented with facilitated subcutaneous immunoglobulin when they either had IgG concentration < 500 mg/dl or between 500 and 700 mg/dl and recurrent infection. The IgG concentration < 500 mg/dL was diagnosed in 41 patients, while 500–700 mg/dL in 25 and altogether 53 patients received IgG supplementation. The median number of IgG administrations was 2. The median time to the first IgG administration after allo-HSCT was 4.1 months, while to the next administration (if more than one was required) 53 days (prophylactic group) and 32 days (group with infections). We did not observe any significant toxicity. Two situations were associated with increased probability of meeting criteria for IgG supplementation: diagnosis of either acute lymphoblastic leukemia (ALL) or chronic lymphocytic leukemia (CLL) (83.8% versus 39.3% for other diagnosis, p = 0.000) and the systemic use of corticosteroids (64.2% versus 31.5% for patients without systemic corticosteroids, p = 0.005). Over 40% of the adult recipients may require at least incidental immunoglobulin supplementation during the first year after allo-HSCT. Low IgG concentrations are associated with inferior outcomes. The subcutaneous route of IgG administration appeared to be safe and may allow for long persistence.
A Preliminary Survey of the Distribution of Segmented Filamentous Bacteria in the Porcine Gastrointestinal Tract
Authors: Grześkowiak Łukasz , Martínez-Vallespín Beatriz , Zentek Jürgen , Vahjen Wilfried 
Published: September 2021

AbstractSegmented filamentous bacteria (SFB) are present in various animal species including pigs. The aim of this work was to analyze the occurrence of SFB in different parts of the gastrointestinal tract of piglets of different ages. A total of 377 DNA extracts from stomach, jejunum, ileum, cecum and colon digesta, and from feces collected on different time points, originating from 155 animals, were screened by qPCR method with primers specific for the SFB. SFB sequences were detected in 74 of 377 samples (19.6%) from 155 animals in total. SFB were most abundant in ileum (50.0%), cecum (45.0%), and colon (37.0%), followed by feces (14.6%). SFB prevalence in sows was 12.9% (13/101) and 75.9% (41/54) in individual piglets. Of the 41 SFB-positive piglets, only two samples were from pre-weaning animals, while the rest of samples originated from post-weaning piglets. SFB sequences are abundant in post-weaning piglets, but not in suckling or adult animals. They are most abundant in the ileum and cecum of pigs. Further studies are warranted to reveal the role of SFB in pigs.
Thermal effects of thulium: YAG laser treatment of the prostate—an in vitro study
Authors: Hein Simon , Petzold Ralf , Suarez-Ibarrola Rodrigo , Schoenthaler Martin , Gratzke Christian , Miernik Arkadiusz 
Published: September 2021

Abstract
Purpose
To objectively determine whether there is potential thermal tissue damage during Tm:YAG laser-based LUTS treatment.

Methods
Our experimental model was comprised of a prostatic resection trainer placed in a 37 °C water bath. In a hollowed-out central area simulating the urethral lumen, we placed a RigiFib 800 fibre, irrigation inflow regulated with a digital pump, and a type K thermocouple. A second thermocouple was inserted 0.5/1 cm adjacently and protected with an aluminum barrier to prevent it from urethral fluid. We investigated continuous and intermittent 120 W and 80 W laser application with various irrigation rates in eight measurement sessions lasting up to 14 min. Thermal measurements were recorded continuously and in real-time using MatLab. All experiments were repeated five times to balance out variations.

Results
Continuous laser application at 120 W and 125 ml/min caused a urethral ∆T of ~ 15 K and a parenchymal temperature increase of up to 7 K. With 50 ml/min irrigation, a urethral and parenchymal ∆T of 30 K and 15 K were reached, respectively. Subsequently and in absence of laser application, prostatic parenchyma needed over 16 min to reach baseline body temperature. At 80 W lower temperature increases were reached compared to similar irrigation but higher power.

Conclusions
We showed that potentially harming temperatures can be reached, especially during high laser power and low irrigation. The heat generation can also be conveyed to the prostate parenchyma and deeper structures, potentially affecting the neurovascular bundles. Further clinical studies with intracorporal temperature measurement are necessary to further investigate this potentially harming surgical adverse effect.
Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis
Authors: Sari Motlagh Reza , Abufaraj Mohammad , Karakiewicz Pierre I. , Rajwa Pawel , Mori Keiichiro , Mun Dong-Ho , Shariat Shahrokh F. 
Published: September 2021

Abstract
Purpose
Androgen-regulated enzymes such as the angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are involved in the SARS-CoV-2 infection process. The expression of TMPRSS2 and its fusion gene, which are increased in the epithelium of the human prostate gland during prostate carcinogenesis, are regulated by androgens. Our goal was to assess the risk of the SARS-CoV-2 infection and the severity of the disease in PCa patients treated with androgen deprivation therapy (ADT).

Methods
We conducted a systematic review and meta-analysis according to PRISMA guidelines. We queried PubMed and Web of Science databases on 1 July 2021. We used random- and/or fixed-effects meta-analytic models in the presence or absence of heterogeneity according to Cochrane’s Q test and I2 statistic, respectively.

Results
Six retrospective studies (n = 50,220 patients) were selected after considering inclusion and exclusion criteria for qualitative evidence synthesis. Four retrospective studies were included to assess the SARS-CoV-2 infection risk in PCa patients under ADT vs. no ADT and the summarized risk ratio (RR) was 0.8 (95% confidence intervals (CI) 0.44–1.47). Five retrospective studies were included to assess the severity of coronavirus disease 2019 (COVID-19) in PCa patients under ADT versus no ADT and the summarized RR was 1.23 (95% CI 0.9–1.68).

Conclusion
We found a non-significant association between the risk of SARS-CoV-2 infection and COVID-19 severity in PCa patients treated with ADT. However, our results suggest that during the COVID-19 pandemic PCa patients can safely undergo ADT as a cancer therapy without worsening COVID-19 risk and trajectory.
Experimental ex-vivo performance study comparing a novel, pulsed thulium solid-state laser, chopped thulium fibre laser, low and high-power holmium:YAG laser for endoscopic enucleation of the prostate
Authors: Yilmaz Mehmet , Esser Julia , Kraft Lea , Petzold Ralf , Sigle August , Gratzke Christian , Suarez-Ibarrola Rodrigo , Miernik Arkadiusz 
Published: September 2021

Abstract
Purpose
The aim of this study was to compare the enucleation performances of four different types of laser devices in an ex-vivo experiment: a novel, pulsed Tm:YAG solid-state laser evaluation model (p-Tm:YAG), chopped thulium fibre laser (TFL), low-power Ho:YAG laser (LP-Ho:YAG), and a high-power Ho:YAG laser (HP-Ho:YAG).

Methods
Our primary aim was to endoscopically separate the fascial layers of a porcine belly using laser fibres within a time period of 60 s. The size of a “tissue pocket” was assessed numerically. The enucleation characteristics reflecting the surgeon’s experience were evaluated via the NASA Task Load Index (TLX) questionnaire and a questionnaire based on Likert scale.

Results
HP-Ho:YAG achieved with the available laser settings the largest overall “tissue pocket” (31.5 cm2) followed by p-Tm:YAG (15 cm2), TFL (12 cm2), and LP-Ho:YAG (6 cm2). The coagulation performances of p-Tm:YAG and TFL were rated the best. In the performance evaluation by the Likert questionnaire, HP-Ho:YAG (average score of 4.06) was rated highest, followed by p-Tm:YAG (3.94), TFL (3.38), and LP-Ho:YAG (3.25). The evaluation of the NASA-TLX performance questionnaire revealed average scores for HP-Ho:YAG, LP-Ho:YAG, TFL and p-Tm:YAG of 4.38, 4.09, 3.92 and 3.90, respectively.

Conclusion
We are the first to compare different laser devices and settings in an ex-vivo study. We found that the surgeons were most satisfied with the HP-Ho:YAG laser device, followed by the p-Tm:YAG. These findings could be highly relevant for future research and for the practical utilisation of laser systems in endourology.
Comparing Boosting and Bagging for Decision Trees of Rankings
Authors: Plaia Antonella , Buscemi Simona , Fürnkranz Johannes , Mencía Eneldo Loza 
Published: September 2021

AbstractDecision tree learning is among the most popular and most traditional families of machine learning algorithms. While these techniques excel in being quite intuitive and interpretable, they also suffer from instability: small perturbations in the training data may result in big changes in the predictions. The so-called ensemble methods combine the output of multiple trees, which makes the decision more reliable and stable. They have been primarily applied to numeric prediction problems and to classification tasks. In the last years, some attempts to extend the ensemble methods to ordinal data can be found in the literature, but no concrete methodology has been provided for preference data. In this paper, we extend decision trees, and in the following also ensemble methods to ranking data. In particular, we propose a theoretical and computational definition of bagging and boosting, two of the best known ensemble methods. In an experimental study using simulated data and real-world datasets, our results confirm that known results from classification, such as that boosting outperforms bagging, could be successfully carried over to the ranking case.
Trace element fractionation between biotite, allanite, and granitic melt
Authors: Were Patrick , Keppler Hans 
Published: September 2021

AbstractThe partitioning of a large suite of trace elements between biotite and water-saturated granitic melt was measured at 2 kbar and 700—800 ˚C. To reach equilibrium and to grow biotite crystals large enough for analysis, runs usually lasted from 30 to 45 days. In every charge, a few trace elements were initially doped at the 0.1—0.5 wt. % level and analyzed by electron microprobe after the run. First-row transition metal ions are highly compatible in biotite with Dbiotite/melt of 17 for Ti, 35 for V, 47 for Co, 174 for Ni, and 5.8 for Zn. A very notable exception is Cu with Dbiotite/melt < 0.9. This is likely one of the reasons why Cu is enriched together with Mo (Dbiotite/melt = 0.29) in porphyry deposits associated with intermediate to felsic plutons, while the other transition metals are not. Both Nb and Ta are mildly compatible in biotite with Dbiotite/melt being larger for Nb (3.69) than for Ta (1.89). Moderate (15—30%) biotite fractionation would be sufficient to reduce the Nb/Ta ratio from the chondritic value to the range observed in the continental crust. Moreover, the strong partitioning of Ti into biotite implies that already modest biotite fractionation suppresses the saturation of Ti-oxide phases and thereby indirectly facilitates the enrichment of Ta over Nb in the residual melt. The heavy alkalis, alkaline earths, and Pb are only mildly fractionated between biotite and melt (Dbiotite/melt = 3.8 for Rb, 0.6 for Cs, 0.6 for Sr, 1.8 for Ba, 0.7 for Pb). The rare earth elements are generally incompatible in biotite, with a minimum for Dbiotite/melt of 0.03–0.06 at Gd, Tb, and Dy, while both the light and heavy rare earths are less incompatible (e.g. Dbiotite/melt = 0.6 for La and 0.3 for Yb). This behavior probably reflects a partitioning into two sites, the K site for the light rare earths and the octahedral Mg site for the heavy rare earths. There is no obvious dependence of the rare earth partition coefficients on tetrahedral Al in the biotite, presumably because charge balancing by cation vacancies is possible. Allanite was found as run product in some experiments. For the light rare earths, Dallanite/melt is very high (e.g. 385 to 963 for Ce and Nd) and appears to increase with decreasing temperatures. However, the rather high solubility of allanite in the melts implies that it likely only crystallizes during the last stages of cooling of most magmas, except if the source magma is unusually enriched in rare earths.
The role of PMCT for the assessment of the cause of death in natural disaster (landslide and flood): a Sicilian experience
Authors: Mondello Cristina , Baldino Gennaro , Bottari Antonio , Sapienza Daniela , Perri Fabrizio , Argo Antonina , Asmundo Alessio , Ventura Spagnolo Elvira 
Published: September 2021

AbstractIn this report, the authors provide a contribution of PMCT in assessing the cause of death due to natural disasters. Here, the PMCT findings of 43 subjects who died during both landslide and flood were described. The post-mortem imaging revealed, clearly, traumatic injuries and/or the presence of foreign material in airways allowing to assess the cause of death of each subject, together with external inspection and the collected circumstantial data. Particularly, the PMCT has been helpful for characterization and localization of the clogging substance in airways providing findings on bronchial branches involvement. Moreover, the investigation offered detailed data on skeletal injuries in all anatomic districts and put in evidence both the precise fracturing site and the characteristics of fracture stubs for each bone fracture. This report supports the recommendation of the virtual autopsy in a case with several victims, as in natural disasters, and its role as an alternative diagnostic investigation when the standard autopsy is not feasible.
Child suicides in Sweden, 2000–2018
Authors: Junuzovic Mensura , Lind Kaja Maria Toporska , Jakobsson Ulf 
Published: September 2021

AbstractAlthough child mortality is decreasing in Sweden, an increase in suicide rates has been previously observed among children and adolescents collectively. To increase knowledge about trends, demographics, and means in child suicides, data including all child (< 18 years) suicides in Sweden in 2000 through 2018 were retrieved from the Swedish National Board of Forensic Medicine. In all, a total of 416 child suicides were found in a 19-year period, accounting for an annual suicide rate of 1.1/100,000 child population. The number of suicides increased with 2.2% by each successive year during the study period (p < 0.001). The mean age in both sexes was 16 years; boys accounted for 55% and girls for 45% of all study cases. The majority of the children who died by suicide (96%) were teenagers (13–17 years old) and suicides in children younger than 10 years were uncommon. Suicide methods were 59% hanging, 20% lying/jumping in front of a moving object, 8% jumping from a height, 7% firearm injury, 4% poisoning, and 2% other methods. Sex differences were significant (p < 0.001) only for firearms being preferably used by boys. The vast majority of firearms used were licensed long-barreled weapons.Conclusion: The number of child suicides in Sweden is relatively low but increasing. Most of the children used a violent and highly lethal method. Prevention of premature mortality is an urgent concern with an emphasis on resolutely reducing the availability of suicide means.What is Known:• Suicide is a significant cause of death globally among children, bringing tragic consequences for young individuals, their family, and the entire society.• Suicide rates and distribution of suicide methods in children differ between countries and settings, but studies of time trends are scarce.What is New:• Increasing number of minors’ suicides and the predominance of violent methods emphasize the importance of prevention strategies tailored for a child population.• Even in a setting of very restrictive firearm laws, firearm suicides in children must not be overlooked.
Subretinal fibrosis in neovascular age-related macular degeneration: current concepts, therapeutic avenues, and future perspectives
Authors: Tenbrock Louis , Wolf Julian , Boneva Stefaniya , Schlecht Anja , Agostini Hansjürgen , Wieghofer Peter , Schlunck Günther , Lange Clemens 
Published: September 2021

AbstractAge-related macular degeneration (AMD) is a progressive, degenerative disease of the human retina which in its most aggressive form is associated with the formation of macular neovascularization (MNV) and subretinal fibrosis leading to irreversible blindness. MNVs contain blood vessels as well as infiltrating immune cells, myofibroblasts, and excessive amounts of extracellular matrix proteins such as collagens, fibronectin, and laminin which disrupts retinal function and triggers neurodegeneration. In the mammalian retina, damaged neurons cannot be replaced by tissue regeneration, and subretinal MNV and fibrosis persist and thus fuel degeneration and visual loss. This review provides an overview of subretinal fibrosis in neovascular AMD, by summarizing its clinical manifestations, exploring the current understanding of the underlying cellular and molecular mechanisms and discussing potential therapeutic approaches to inhibit subretinal fibrosis in the future.