bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction to the special issue on institutions and culture in economic contexts
Authors: Andriani Luca , Luca Bruno Randolph 
Published: September 2021

AbstractThe need of further research on the interlink between culture and institutions has been strongly advocated by economists and institutionalists alike. However, bringing together culture and institutions within an organic framework, though, is a non-trivial operation. This is due to the complexity of the synergies between cultural aspects and institutional devices. This special issue attempts to start filling this gap and to build anad-hocsystemic platform for disseminating such a debate. To this purpose, it brings together an organic collection of contributions in well-established conceptualisations of both culture and institutions, supported by robust and consistent methodological applications. The essays presented in this work provide consistent evidence and conceptual perspectives supporting the idea that the synergies between cultural and institutional aspects are of paramount importance to understand human behaviour, individuals' choices and societies' patterns. They also improve the theoretical, empirical and methodological understanding of the role of institutions and culture in different geopolitical and socio-economic realms. By doing so, these contributions place this special issue as prelude to further research on the co-evolution of culture and institutions and on its possible implications on different societal aspects, human development and well-being.
Clinical supervision in CBT training: what do participants view as effective?
Authors: Kelly Nicola , Hassett Alex 
Published: September 2021

AbstractLiterature pertaining to cognitive behavioural therapy (CBT) supervision is limited, particularly about CBT supervision during training. This exploratory study outlines the thoughts of supervisors and supervisees in a training context about which elements make supervision effective. Four supervisees and four experienced CBT supervisors (all from a CBT training programme and independent of one another) were interviewed and asked to consider what makes CBT supervision during training effective. Their responses were evaluated using thematic analysis (TA) and key themes identified. The fit with existing literature was considered via the use of an adapted Delphi poll. Two main themes, containing seven subthemes, were identified from the thematic analysis: ‘supervision as structured learning’ and ‘supervisory relations and process’. The adapted Delphi poll was divided into six categories denoting important characteristics of CBT supervision: (1) the supervisory relationship, (2) ethical factors, (3) generic supervisory skills, (4) mirroring the CBT approach, (5) the supervisor’s knowledge and (6) addressing difficulties. There was a good fit between the TA themes and the Delphi categories. For those engaging in CBT supervision, establishing a structure that mirrors a CBT session, alongside a supportive supervisory alliance, may promote effective CBT supervision during training.Key learning aims(1)To consider what might make CBT supervision during training a better experience for participants, such as alliance factors and structured learning.(2)To discover how supervisors’ and trainees’ perspectives fit with existing research on CBT supervision.(3)To consider some potential supervisory implications related to aspects of CBT supervision that participants find useful.
Geochemical and C‐O Isotopic Study of Ophiolite‐Derived Carbonates of the Barzaman Formation, Oman: Evidence of Natural CO2 Sequestration Via Carbonation of Ultramafic Clasts
Authors: Ali Arshad , Abbasi Iftikhar Ahmed , Nogueira Leonardo Brandão , Hersi Osman Salad , Al Kindi Sumaiya A. N. , El‐Ghali Mohamed A. K. , Nasir Sobhi Jaber 
Published: September 2021

AbstractCarbonate precipitation through atmospheric CO2 uptake by alkaline‐hyperalkaline waters offers a potential approach to mitigating anthropogenic CO2 emissions. The Oman Ophiolite produces high‐pH water characterized by continuous sequestration of CO2 at the air‐water interface. The geochemical and isotopic data of carbonates from the Barzaman Formation is used to assess the amount of atmospheric CO2 stored in the dolomite‐calcite assemblage. Post Archean Australian Shale ‐normalized rare earth elements patterns, with the exception of La and Ce anomalies, are similar to those of the bulk oceanic and lower crusts, with increasing LREE and flat HREE trends, and a positive Eu anomaly. The δ13CVPDB and δ18OVSMOW isotope values of the analyzed samples show two distinct end‐members, in which dolomite (−7.77‰ and +27.3‰) is isotopically heavier than calcite (−9.93‰ and +21.5‰). The estimated carbonate growth temperatures (18°C–56°C) are indistinguishable from the previously reported range (18°C–66°C). The C‐O isotope model for calcite, groundwater, and atmospheric CO2 shows that an ophiolite‐derived calcite sample absorbed an unequivocal amount of atmospheric CO2 (78% ± 11%) during precipitation. At the same time, dissolved inorganic carbon (DIC) in water accounts for the remaining carbon contribution (22% ± 9%). DIC is closely associated with different carbonate lithofacies and ophiolite‐derived soil, exhibiting large variations in C‐O isotopic compositions caused by isotopic disequilibrium. Taken together, geochemical and isotopic properties confirm that the carbonates were formed under oxic conditions triggered by the water‐rock interaction. For a reliable estimate of CO2 sequestered by carbonates of the Barzaman Formation, a systematic groundwater analysis is recommended to determine the contribution of CO2 in DIC.
Synchronous Emplacement of the Anorthosite Xenolith‐Bearing Beaver River Diabase and One of the Largest Lava Flows on Earth
Authors: Zhang Yiming , Swanson‐Hysell Nicholas L. , Schmitz Mark D. , Miller James D. , Avery Margaret S. 
Published: September 2021

AbstractNew geochronologic and paleomagnetic data from the North American Midcontinent Rift (MCR) reveal the synchronous emplacement of the Beaver River diabase, the anorthosite xenoliths within it, and the Greenstone Flow—one of the largest lava flows on Earth. A U‐Pb zircon date of 1091.83 0.21 Ma (2) from one of the anorthosite xenoliths is consistent with the anorthosite cumulate forming as part of the MCR and provides a maximum age constraint for the Beaver River diabase. Paired with the minimum age constraint of a cross‐cutting Silver Bay intrusion (1091.61 0.14 Ma; 2), these data tightly bracket the age of the Beaver River diabase to be 1091.7 0.2 Ma (95% CI), coeval with the eruption of the Greenstone Flow (1091.59 0.27 Ma; 2)—which is further supported by indistinguishable tilt‐corrected paleomagnetic pole positions. Geochronological, paleomagnetic, mineralogical and geochemical data are consistent with a hypothesis that the Beaver River diabase was the feeder system for the Greenstone Flow. The large areal extent of the intrusives and large estimated volume of the volcanics suggest that they represent a rapid and voluminous ca. 1,092 Ma magmatic pulse near the end of the main stage of MCR magmatism.
Stratospheric Fluorine as a Tracer of Circulation Changes: Comparison Between Infrared Remote‐Sensing Observations and Simulations With Five Modern Reanalyses
Authors: Prignon M. , Chabrillat S. , Friedrich M. , Smale D. , Strahan S. E. , Bernath P. F. , Chipperfield M. P. , Dhomse S. S. , Feng W. , Minganti D. , Servais C. , Mahieu E. 
Published: September 2021

AbstractUsing multidecadal time series of ground‐based and satellite Fourier transform infrared measurements of inorganic fluorine (i.e., total fluorine resident in stratospheric fluorine reservoirs), we investigate stratospheric circulation changes over the past 20 years. The representation of these changes in five modern reanalyses is further analyzed through chemical‐transport model (CTM) simulations. From the observations but also from all reanalyses, we show that the inorganic fluorine is accumulating less rapidly in the Southern Hemisphere than in the Northern Hemisphere during the 21st century. Comparisons with a study evaluating the age‐of‐air of these reanalyses using the same CTM allow us to link this hemispheric asymmetry to changes in the Brewer‐Dobson circulation (BDC), with the age‐of‐air of the Southern Hemisphere getting younger relative to that of the Northern Hemisphere. Large differences in simulated total columns and absolute trend values are, nevertheless, depicted between our simulations driven by the five reanalyses. Superimposed on this multidecadal change, we, furthermore, confirm a 5–7‐year variability of the BDC that was first described in a recent study analyzing long‐term time series of hydrogen chloride (HCl) and nitric acid (HNO3). It is important to stress that our results, based on observations and meteorological reanalyses, are in contrast with the projections of chemistry‐climate models in response to the coupled increase of greenhouse gases and decrease of ozone‐depleting substances, calling for further investigations and the continuation of long‐term observations.
An Eddy‐Resolving Numerical Model to Study Turbulent Flow, Sediment, and Bed Evolution Using Detached Eddy Simulation in a Lateral Separation Zone at the Field‐Scale
Authors: Alvarez Laura V. , Grams Paul E. 
Published: September 2021

AbstractTurbulence‐resolving simulations elucidate key elements of fluid dynamics and sediment transport in fluvial environments. This research presents a feasible strategy for applying state‐of‐the‐art computational fluid mechanics to the study of sediment transport and morphodynamic processes in lateral separation zones, which are common features in canyon rivers where massive lateral flow separation causes large‐scale turbulence that controls sediment erosion and deposition. An eddy‐resolving model was developed and tested at the field‐scale, coupling a viscous flow and sediment transport solver using Detached Eddy Simulation techniques. A morphodynamic model was applied to the viscous flow/sediment solver to calculate erosion and deposition. A simulation of turbulence was performed at the grid resolution for a straight channel to determine the relative contributions of modeled and resolved diffusivity. The time‐dependent, energetically important, correlative, non‐stationary signals of the simulated quantities were captured at the lateral separation zone. Strong periodic signals featured by high amplitude were found at the separation zone, while low frequency pulsations were observed at the reattachment zone of the lateral separation zone. Interactions between the eddies and the loose bed boundaries resulted in erosion of sediment at the main channel followed by deposition at the primary eddy and eddy bars.
Are Deep Aquifers Really Confined? Insights From Deep Groundwater Tidal Responses in the North China Platform
Authors: Zhang Yan , Wang Chi‐Yuen , Fu Li‐Yun , Yang Qiu‐Ye 
Published: September 2021

AbstractMany deep aquifers overlain by barrier formations in the continental US are used as geological repositories for wastewaters coproduced from hydrocarbon exploration. This practice is to protect shallow groundwater following the US Environmental Protection Agency’s regulation. Implicit in such practice is the assumption that deep aquifers overlain by mudstones or shales are confined so that the injected fluids will not migrate upward to contaminate shallow groundwater. However, no systematic test of this hypothesis has been made. Here we invert the groundwater response to both the M2 and the O1 tides and to the barometric pressure across a large (2.046 × 106 km2) geologic regime, the North China Platform, to systematically evaluate the hydraulic parameters as functions of depth and time without a priori assumption. Our result, the first of such inversion, shows no depth dependence of aquifer confinement to a depth of 3,400 m and that deep confined aquifers overlain by barrier formations may become leaky after distant earthquakes. It suggests that monitoring of aquifer confinement may be needed to ensure if the targeted deep aquifer for wastewater injection is really confined. The results may be timely and of global significance because the practice of hydrofracking for natural gas and the deep injection for the disposal of the coproduced wastewaters in the US may soon be adopted by other countries, such as China.
Laboratory Flume and Numerical Modeling Experiments Show Log Jams and Branching Channels Increase Hyporheic Exchange
Authors: Wilhelmsen K. , Sawyer A. H. , Marshall A. , McFadden S. , Singha K. , Wohl E. 
Published: September 2021

AbstractLog jams alter gradients in hydraulic head, increase the area available for hyporheic exchange by creating backwater areas, and lead to the formation of multiple channel branches and bars that drive additional exchange. Here, we numerically simulated stream‐groundwater interactions for two constructed flume systems—one without jams and one with a series of three jams—to quantify the effects of interacting jam structures and channel branches on hyporheic exchange at three stream flow rates. In simulations without jams, average hyporheic exchange rates ranged from 2.1 × 10−4 to 2.9 × 10−4 m/s for various stream discharge scenarios, but with jams, exchange rates increased to a range of 1.3 × 10−3–3.5 × 10−3 m/s. Largely due to these increased hyporheic exchange rates, jams increased stream‐groundwater connectivity or decreased the turnover length that stream water travels before interacting with the hyporheic zone, by an order of magnitude, and drove long flow paths that connected multiple jams and channel threads. Decreased turnover lengths corresponded with greater reaction significance per km, a measure of the potential for the hyporheic zone to influence stream water chemistry. For low‐flow conditions, log jams increased reaction significance per km five‐fold, from 0.07 to 0.35. Jams with larger volumes led to longer hyporheic residence times and path lengths that exhibited multiple scales of exchange. Additionally, the longest flow paths connecting multiple jams occurred in the reach with multiple channel branches. These findings suggest that large gains in hydrologic connectivity can be achieved by promoting in‐stream wood accumulation and the natural formation of both jams and branching channels.
Genomic and transcriptomic analyses reveal a tandem amplification unit of 11 genes and mutations in mismatch repair genes in methotrexate-resistant HT-29 cells
Authors: Kim Ahreum , Shin Jong-Yeon , Seo Jeong-Sun 
Published: September 2021

AbstractDHFR gene amplification is commonly present in methotrexate (MTX)-resistant colon cancer cells and acute lymphoblastic leukemia. In this study, we proposed an integrative framework to characterize the amplified region by using a combination of single-molecule real-time sequencing, next-generation optical mapping, and chromosome conformation capture (Hi-C). We identified an amplification unit spanning 11 genes, from the DHFR gene to the ATP6AP1L gene position, with high adjusted interaction frequencies on chromosome 5 (~2.2 Mbp) and a twenty-fold tandemly amplified region, and novel inversions at the start and end positions of the amplified region as well as frameshift insertions in most of the MSH and MLH genes were detected. These mutations might stimulate chromosomal breakage and cause the dysregulation of mismatch repair. Characterizing the tandem gene-amplified unit may be critical for identifying the mechanisms that trigger genomic rearrangements. These findings may provide new insight into the mechanisms underlying the amplification process and the evolution of drug resistance.
Inter-rater reliability of the neonatal adverse event severity scale using real-world Neonatal clinical trial data
Authors: Lewis Tamorah , Terrin Norma , Davis Jonathan , Michels Kurt , Salaets Thomas , Wade Kelly ,   International Neonatal Consortium
Published: September 2021

Abstract
Objective
The Neonatal Adverse Event Severity Scale (NAESS) was developed to improve scoring of neonatal adverse events (AEs) and accelerate neonatal drug development. This is the first validation study of the novel tool.

Study design
Retrospective validation study assessing the inter-rater reliability (IRR) of the NAESS. Reviewers used real-world AE data from a neonatal trial. Intra-class correlation (ICC) statistical analysis was performed.

Result
Sixty AEs were randomly assigned to twelve reviewers for a total of 240 severity scores. Generic and AE-specific NAESS tables were assessed. The ICC was 0.63 (95% confidence interval 0.51 to 0.73). Percent variation due to reviewer and residual error was 0.03 and 0.34, respectively.

Conclusion
In this first study of the NAESS tool, an ICC of 0.63 indicates moderate reliability. Results highlight the need for improved data collection on neonatal AE forms, augmented training on the NAESS tool, and will inform the prospective validation studies.
AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1–Bcl-6 axis-mediated B-cell differentiation
Authors: Yang Ming , Long Di , Hu Longyuan , Zhao Zhidan , Li Qianwen , Guo Yunkai , He Zhenghao , Zhao Ming , Lu Liwei , Li Fen , Long Hai , Wu Haijing , Lu Qianjin 
Published: September 2021

AbstractAbsent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher AIM2 expression is observed in the B cells from lupus patients. To date, the inflammasome-independent function of AIM2 in B cells remains unclear. Here, we report increased expression of AIM2 in human tonsil memory and germinal center (GC) B cells and in memory B cells and plasma cells from the circulation and skin lesions of lupus patients. Conditional knockout of AIM2 in B cells reduces the CD19+ B-cell frequency in lymph nodes and spleens, and dampens KLH-induced IgG1-antibody production. In a pristane-induced mouse model of lupus, AIM2 deficiency in B cells attenuates lupus symptoms and reduces the frequency of GC B cells, T follicular helper (Tfh) cells, plasmablast cells, and plasma cells. Furthermore, the loss of AIM2 in human B cells leads to the increased expression of Blimp-1 and reduces the expression of Bcl-6. However, the silencing of Blimp-1 and Bcl-6 has no significant effect on AIM2 expression, indicating that AIM2 might be the upstream regulator for Blimp-1 and Bcl-6. In addition, IL-10 is found to upregulate AIM2 expression via DNA demethylation. Together, our findings reveal that AIM2 is highly expressed in the B cells of lupus patients and promotes B-cell differentiation by modulating the Bcl-6–Blimp-1 axis, providing a novel target for SLE treatment.
Plant-microbe interactions in the phyllosphere: facing challenges of the anthropocene
Authors: Perreault Rosaëlle , Laforest-Lapointe Isabelle 
Published: September 2021

Abstract
Global change is a defining feature of the Anthropocene, the current human-dominated epoch, and poses imminent threats to ecosystem dynamics and services such as plant productivity, biodiversity, and environmental regulation. In this era, terrestrial ecosystems are experiencing perturbations linked to direct habitat modifications as well as indirect effects of global change on species distribution and extreme abiotic conditions. Microorganisms represent an important reservoir of biodiversity that can influence macro-organisms as they face habitat loss, rising atmospheric CO2 concentration, pollution, global warming, and increased frequency of drought. Plant-microbe interactions in the phyllosphere have been shown to support plant growth and increase host resistance to biotic and abiotic stresses. Here, we review how plant-microbe interactions in the phyllosphere can influence host survival and fitness in the context of global change. We highlight evidence that plant-microbe interactions (1) improve urban pollution remediation through the degradation of pollutants such as ultrafine particulate matter, black carbon, and atmospheric hydrocarbons, (2) have contrasting impacts on plant species range shifts through the loss of symbionts or pathogens, and (3) drive plant host adaptation to drought and warming. Finally, we discuss how key community ecology processes could drive plant-microbe interactions facing challenges of the Anthropocene.
In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens
Authors: Halasohoris Stephanie A. , Scarff Jennifer M. , Pysz Lisa M. , Lembirik Sanae , Lemmon Margaret M. , Biek Donald , Hannah Brendan , Zumbrun Steven D. , Panchal Rekha G. 
Published: September 2021

AbstractAntimicrobial-resistance (AMR) has become an increasingly difficult issue to overcome for bacteria associated with both community- and hospital-acquired infections as well as potential biodefense threats. The need to identify new therapeutics of novel classes and/or with unique mechanisms is critical to combatting AMR in the coming years. GT-1 (LCB10-0200), a siderophore-linked cephalosporin, is one such novel option and is formulated to be used either alone or in combination with a novel broad-spectrum β-lactamase inhibitor, GT-055 (LCB18-055). This study assessed the in vitro and in vivo efficacy of GT-1 and GT-055 against a broad array of multi-drug resistant and biothreat pathogens. Here, we demonstrated sub-4 µg ml−1 efficacy against a number of pathogens in vitro. We further determined that in mice infected via aerosol route with Yersinia pestis, efficacy of GT-1/GT-055 treatment is at least equivalent to the comparator antibiotic, ciprofloxacin.
Tunable and functional deep eutectic solvents for lignocellulose valorization
Authors: Liu Yongzhuang , Deak Noemi , Wang Zhiwen , Yu Haipeng , Hameleers Lisanne , Jurak Edita , Deuss Peter J. , Barta Katalin 
Published: September 2021

AbstractStabilization of reactive intermediates is an enabling concept in biomass fractionation and depolymerization. Deep eutectic solvents (DES) are intriguing green reaction media for biomass processing; however undesired lignin condensation is a typical drawback for most acid-based DES fractionation processes. Here we describe ternary DES systems composed of choline chloride and oxalic acid, additionally incorporating ethylene glycol (or other diols) that provide the desired ‘stabilization’ function for efficient lignocellulose fractionation, preserving the quality of all lignocellulose constituents. The obtained ethylene-glycol protected lignin displays high β-O-4 content (up to 53 per 100 aromatic units) and can be readily depolymerized to distinct monophenolic products. The cellulose residues, free from condensed lignin particles, deliver up to 95.9 ± 2.12% glucose yield upon enzymatic digestion. The DES can be recovered with high yield and purity and re-used with good efficiency. Notably, we have shown that the reactivity of the β-O-4 linkage in model compounds can be steered towards either cleavage or stabilization, depending on DES composition, demonstrating the advantage of the modular DES composition.