bluuebunny/crossref_metadata_2025_split huggingface dataset:
A durable and pH-universal self-standing MoC–Mo2C heterojunction electrode for efficient hydrogen evolution reaction
Authors: Liu Wei , Wang Xiting , Wang Fan , Du Kaifa , Zhang Zhaofu , Guo Yuzheng , Yin Huayi , Wang Dihua 
Published: November 2021

AbstractEfficient water electrolyzers are constrained by the lack of low-cost and earth-abundant hydrogen evolution reaction (HER) catalysts that can operate at industry-level conditions and be prepared with a facile process. Here we report a self-standing MoC–Mo2C catalytic electrode prepared via a one-step electro-carbiding approach using CO2 as the feedstock. The outstanding HER performances of the MoC–Mo2C electrode with low overpotentials at 500 mA cm−2 in both acidic (256 mV) and alkaline electrolytes (292 mV), long-lasting lifetime of over 2400 h (100 d), and high-temperature performance (70 oC) are due to the self-standing hydrophilic porous surface, intrinsic mechanical strength and self-grown MoC (001)–Mo2C (101) heterojunctions that have a ΔGH* value of −0.13 eV in acidic condition, and the energy barrier of 1.15 eV for water dissociation in alkaline solution. The preparation of a large electrode (3 cm × 11.5 cm) demonstrates the possibility of scaling up this process to prepare various carbide electrodes with rationally designed structures, tunable compositions, and favorable properties.
De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide
Authors: Shimizu Keisuke , Mijiddorj Batsaikhan , Usami Masataka , Mizoguchi Ikuro , Yoshida Shuhei , Akayama Shiori , Hamada Yoshio , Ohyama Akifumi , Usui Kenji , Kawamura Izuru , Kawano Ryuji 
Published: November 2021

AbstractThe amino-acid sequence of a protein encodes information on its three-dimensional structure and specific functionality. De novo design has emerged as a method to manipulate the primary structure for the development of artificial proteins and peptides with desired functionality. This paper describes the de novo design of a pore-forming peptide, named SV28, that has a β-hairpin structure and assembles to form a stable nanopore in a bilayer lipid membrane. This large synthetic nanopore is an entirely artificial device for practical applications. The peptide forms multidispersely sized nanopore structures ranging from 1.7 to 6.3 nm in diameter and can detect DNAs. To form a monodispersely sized nanopore, we redesigned the SV28 by introducing a glycine-kink mutation. The resulting redesigned peptide forms a monodisperse pore with a diameter of 1.7 nm leading to detection of a single polypeptide chain. Such de novo design of a β-hairpin peptide has the potential to create artificial nanopores, which can be size adjusted to a target molecule.
Benefit of human moderate running boosting mood and executive function coinciding with bilateral prefrontal activation
Authors: Damrongthai Chorphaka , Kuwamizu Ryuta , Suwabe Kazuya , Ochi Genta , Yamazaki Yudai , Fukuie Takemune , Adachi Kazutaka , Yassa Michael A. , Churdchomjan Worachat , Soya Hideaki 
Published: November 2021

AbstractRunning, compared to pedaling is a whole-body locomotive movement that may confer more mental health via strongly stimulating brains, although running impacts on mental health but their underlying brain mechanisms have yet to be determined; since almost the mechanistic studies have been done with pedaling. We thus aimed at determining the acute effect of a single bout of running at moderate-intensity, the most popular condition, on mood and executive function as well as their neural substrates in the prefrontal cortex (PFC). Twenty-six healthy participants completed both a 10-min running session on a treadmill at 50%$${\dot{\text{V}}\text{O}}_{{{\text{2peak}}}}$$V˙O2peakand a resting control session in randomized order. Executive function was assessed using the Stroop interference time from the color-word matching Stroop task (CWST) and mood was assessed using the Two-Dimensional Mood Scale, before and after both sessions. Prefrontal hemodynamic changes while performing the CWST were investigated using functional near-infrared spectroscopy. Running resulted in significant enhanced arousal and pleasure level compared to control. Running also caused significant greater reduction of Stroop interference time and increase in Oxy-Hb signals in bilateral PFCs. Besides, we found a significant association among pleasure level, Stroop interference reaction time, and the left dorsolateral PFCs: important brain loci for inhibitory control and mood regulation. To our knowledge, an acute moderate-intensity running has the beneficial of inducing a positive mood and enhancing executive function coinciding with cortical activation in the prefrontal subregions involved in inhibitory control and mood regulation. These results together with previous findings with pedaling imply the specificity of moderate running benefits promoting both cognition and pleasant mood.
Emotions explain differences in the diffusion of true vs. false social media rumors
Authors: Pröllochs Nicolas , Bär Dominik , Feuerriegel Stefan 
Published: November 2021

AbstractFalse rumors (often termed “fake news”) on social media pose a significant threat to modern societies. However, potential reasons for the widespread diffusion of false rumors have been underexplored. In this work, we analyze whether sentiment words, as well as different emotional words, in social media content explain differences in the spread of true vs. false rumors. For this purpose, we collected $${\varvec{N}} =126{,}301$$

N

=
126
,
301

rumor cascades from Twitter, comprising more than 4.5 million retweets that have been fact-checked for veracity. We then categorized the language in social media content to (1) sentiment (i.e., positive vs. negative) and (2) eight basic emotions (i. e., anger, anticipation, disgust, fear, joy, trust, sadness, and surprise). We find that sentiment and basic emotions explain differences in the structural properties of true vs. false rumor cascades. False rumors (as compared to true rumors) are more likely to go viral if they convey a higher proportion of terms associated with a positive sentiment. Further, false rumors are viral when embedding emotional words classified as trust, anticipation, or anger. All else being equal, false rumors conveying one standard deviation more positive sentiment have a 37.58% longer lifetime and reach 61.44% more users. Our findings offer insights into how true vs. false rumors spread and highlight the importance of managing emotions in social media content.
Structural optimization of silicon thin film for thermoelectric materials
Authors: Hori Takuma 
Published: November 2021

AbstractThe method to optimize nanostructures of silicon thin films as thermoelectric materials is developed. The simulated annealing method is utilized for predicting the optimized structure. The mean free path and thermal conductivity of thin films, which are the objective function of optimization, is evaluated by using phonon transport simulations and lattice dynamics calculations. In small systems composed of square lattices, the simulated annealing method successfully predicts optimized structure corroborated by an exhaustive search. This fact indicates that the simulated annealing method is an effective tool for optimizing nanostructured thin films as thermoelectric materials.
Standard (3, 5)-threshold quantum secret sharing by maximally entangled 6-qubit states
Authors: Long Yinxiang , Zhang Cai , Sun Zhiwei 
Published: November 2021

AbstractIn this paper, a standard (3, 5)-threshold quantum secret sharing scheme is presented, in which any three of five participants can resume cooperatively the classical secret from the dealer, but one or two shares contain absolutely no information about the secret. Our scheme can be fulfilled by using the singular properties of maximally entangled 6-qubit states found by Borras. We analyze the scheme’s security by several ways, for example, intercept-and-resend attack, entangle-and-measure attack, and so on. Compared with the other standard threshold quantum secret sharing schemes, our scheme needs neither to use d-level multipartite entangled states, nor to produce shares by classical secret splitting techniques, so it is feasible to be realized.
Magnetic field compensation coil design for magnetoencephalography
Authors: Kutschka Hermann , Doeller Christian F. , Haueisen Jens , Maess Burkhard 
Published: November 2021

AbstractWhile optically pumped magnetometers (OPMs) can be attached to the head of a person and allow for highly sensitive recordings of the human magnetoencephalogram (MEG), they are mostly limited to an operational range of approximately 5 nT. Consequently, even inside a magnetically shielded room (MSR), movements in the remnant magnetic field disable the OPMs. Active suppression of the remnant field utilizing compensation coils is therefore essential. We propose 8 compensation coils on 5 sides of a cube with a side length of approximately 2 m which were optimized for operation inside an MSR. Compared to previously built bi-planar compensation coils, the coils proposed in this report are more complex in geometry and achieved smaller errors for simulated compensation fields. The proposed coils will allow for larger head movements or smaller movement artifacts in future MEG experiments compared to existing coils.
Reconnecting groups of space debris to their parent body through proper elements
Authors: Celletti Alessandra , Pucacco Giuseppe , Vartolomei Tudor 
Published: November 2021

AbstractSatellite collisions or fragmentations generate a huge number of space debris; over time, the fragments might get dispersed, making it difficult to associate them to the configuration at break-up. In this work, we present a procedure to back-trace the debris, reconnecting them to their original configuration. To this end, we compute the proper elements, namely dynamical quantities which stay nearly constant over time. While the osculating elements might spread and lose connection with the values at break-up, the proper elements, which have been already successfully used to identify asteroid families, retain the dynamical features of the original configuration. We show the efficacy of the procedure, based on a hierarchical implementation of perturbation theory, by analyzing the following four different case studies associated to satellites that underwent a catastrophic event: Ariane 44lp, Atlas V Centaur, CZ-3, Titan IIIc Transtage. The link between (initial and final) osculating and proper elements is evaluated through tools of statistical data analysis. The results show that proper elements allow one to reconnect the fragments to their parent body.
Identification of a new regulation pathway of EGFR and E-cadherin dynamics
Authors: Proux-Gillardeaux Veronique , Advedissian Tamara , Perin Charlotte , Gelly Jean-Christophe , Viguier Mireille , Deshayes Frederique 
Published: November 2021

AbstractE-cadherin and EGFR are known to be closely associated hence regulating differentiation and proliferation notably in epithelia. We have previously shown that galectin-7 binds to E-cadherin and favors its retention at the plasma membrane. In this study, we shed in light that galectin-7 establishes a physical link between E-cadherin and EGFR. Indeed, our results demonstrate that galectin-7 also binds to EGFR, but unlike the binding to E-cadherin this binding is sugar dependent. The establishment of E-cadherin/EGFR complex and the binding of galectin-7 to EGFR thus lead to a regulation of its signaling and intracellular trafficking allowing cell proliferation and migration control. In vivo observations further support these results since an epidermal thickening is observed in galectin-7 deficient mice. This study therefore reveals that galectin-7 controls epidermal homeostasis through the regulation of E-cadherin/EGFR balance.
Generalized radiation model for human migration
Authors: Alis Christian , Legara Erika Fille , Monterola Christopher 
Published: November 2021

AbstractOne of the main problems in the study of human migration is predicting how many people will migrate from one place to another. An important model used for this problem is the radiation model for human migration, which models locations as attractors whose attractiveness is moderated by distance as well as attractiveness of neighboring locations. In the model, the measure used for attractiveness is population which is a proxy for economic opportunities and jobs. However, this may not be valid, for example, in developing countries, and fails to take into account people migrating for non-economic reasons such as quality of life. Here, we extend the radiation model to include the number of amenities (offices, schools, leisure places, etc.) as features aside from population. We find that the generalized radiation model outperforms the radiation model by as much as 10.3% relative improvement in mean absolute percentage error based on actual census data five years apart. The best performing model does not even include population information which suggests that amenities already include the information that we get from population. The generalized radiation model provides a measure of feature importance thus presenting another avenue for investigating the effect of amenities on human migration.
CinE caRdiac magneTic resonAnce to predIct veNTricular arrhYthmia (CERTAINTY)
Authors: Krebs Julian , Mansi Tommaso , Delingette Hervé , Lou Bin , Lima Joao A. C. , Tao Susumu , Ciuffo Luisa A. , Norgard Sanaz , Butcher Barbara , Lee Wei H. , Chamera Ela , Dickfeld Timm-Michael , Stillabower Michael , Marine Joseph E. , Weiss Robert G. , Tomaselli Gordon F. , Halperin Henry , Wu Katherine C. , Ashikaga Hiroshi 
Published: November 2021

AbstractBetter models to identify individuals at low risk of ventricular arrhythmia (VA) are needed for implantable cardioverter-defibrillator (ICD) candidates to mitigate the risk of ICD-related complications. We designed the CERTAINTY study (CinE caRdiac magneTic resonAnce to predIct veNTricular arrhYthmia) with deep learning for VA risk prediction from cine cardiac magnetic resonance (CMR). Using a training cohort of primary prevention ICD recipients (n = 350, 97 women, median age 59 years, 178 ischemic cardiomyopathy) who underwent CMR immediately prior to ICD implantation, we developed two neural networks:Cine Fingerprint ExtractorandRisk Predictor. The former extracts cardiac structure and function features from cine CMR in a form of cine fingerprint in a fully unsupervised fashion, and the latter takes in the cine fingerprint and outputs disease outcomes as a cine risk score. Patients with VA (n = 96) had a significantly higher cine risk score than those without VA. Multivariate analysis showed that the cine risk score was significantly associated with VA after adjusting for clinical characteristics, cardiac structure and function including CMR-derived scar extent. These findings indicate that non-contrast, cine CMR inherently contains features to improve VA risk prediction in primary prevention ICD candidates. We solicit participation from multiple centers for external validation.
Retentive capacity of power output and linear versus non-linear mapping of power loss in the isotonic muscular endurance test
Authors: Xu Hong-qi , Xue Yong-tai , Zhou Zi-jian , Koh Koon Teck , Xu Xin , Shi Ji-peng , Zhang Shou-wei , Zhang Xin , Cai Jing 
Published: November 2021

AbstractThe limit of dynamic endurance during repetitive contractions has been referred to as the point of muscle fatigue, which can be measured by mechanical and electrophysiological parameters combined with subjective estimates of load tolerance for revealing the human real-world capacity required to work continuously. In this study, an isotonic muscular endurance (IME) testing protocol under a psychophysiological fatigue criterion was developed for measuring the retentive capacity of the power output of lower limb muscles. Additionally, to guide the development of electrophysiological evaluation methods, linear and non-linear techniques for creating surface electromyography (sEMG) models were compared in terms of their ability to estimate muscle fatigue. Forty healthy college-aged males performed three trials of an isometric peak torque test and one trial of an IME test for the plantar flexors and knee and hip extensors. Meanwhile, sEMG activity was recorded from the medial gastrocnemius, lateral gastrocnemius, vastus medialis, rectus femoris, vastus lateralis, gluteus maximus, and biceps femoris of the right leg muscles. Linear techniques (amplitude-based parameters, spectral parameters, and instantaneous frequency parameters) and non-linear techniques (a multi-layer perception neural network) were used to predict the time-dependent power output during dynamic contractions. Two mechanical manifestations of muscle fatigue were observed in the IME tests, including power output reduction between the beginning and end of the test and time-dependent progressive power loss. Compared with linear mapping (linear regression) alone or a combination of sEMG variables, non-linear mapping of power loss during dynamic contractions showed significantly higher signal-to-noise ratios and correlation coefficients between the actual and estimated power output. Muscular endurance required in real-world activities can be measured by considering the amount of work produced or the activity duration via the recommended IME testing protocol under a psychophysiological termination criterion. Non-linear mapping techniques provide more powerful mapping of power loss compared with linear mapping in the IME testing protocol.
Tissue and salinity specific Na+/Cl− cotransporter (NCC) orthologues involved in the adaptive osmoregulation of sea lamprey (Petromyzon marinus)
Authors: Barany A. , Shaughnessy C. A. , Pelis R. M. , Fuentes J. , Mancera J. M. , McCormick S. D. 
Published: November 2021

AbstractTwo orthologues of the gene encoding the Na+-Cl− cotransporter (NCC), termed ncca and nccb, were found in the sea lamprey genome. No gene encoding the Na+-K+-2Cl− cotransporter 2 (nkcc2) was identified. In a phylogenetic comparison among other vertebrate NCC and NKCC sequences, the sea lamprey NCCs occupied basal positions within the NCC clades. In freshwater, ncca mRNA was found only in the gill and nccb only in the intestine, whereas both were found in the kidney. Intestinal nccb mRNA levels increased during late metamorphosis coincident with salinity tolerance. Acclimation to seawater increased nccb mRNA levels in the intestine and kidney. Electrophysiological analysis of intestinal tissue ex vivo showed this tissue was anion absorptive. After seawater acclimation, the proximal intestine became less anion absorptive, whereas the distal intestine remained unchanged. Luminal application of indapamide (an NCC inhibitor) resulted in 73% and 30% inhibition of short-circuit current (Isc) in the proximal and distal intestine, respectively. Luminal application of bumetanide (an NKCC inhibitor) did not affect intestinal Isc. Indapamide also inhibited intestinal water absorption. Our results indicate that NCCb is likely the key ion cotransport protein for ion uptake by the lamprey intestine that facilitates water absorption in seawater. As such, the preparatory increases in intestinal nccb mRNA levels during metamorphosis of sea lamprey are likely critical to development of whole animal salinity tolerance.
A SEER-based nomogram accurately predicts prognosis in Ewing’s sarcoma
Authors: Zhan Haibo , Mo Fengbo , Zhu Meisong , Xu Xiaoyu , Zhang Bin , Liu Hucheng , Dai Min 
Published: November 2021

AbstractEwing's sarcoma is a high-grade malignancy bone and soft tissue tumor that most commonly occurs in children and adolescents. Although the overall prognosis of Ewing's sarcoma has improved, the 5-year survival rate has not improved significantly. The study aimed to determine the risk factors independently associated with the prognosis of Ewing's sarcoma and to construct a nomogram to predict patient survival. Patients diagnosed with Ewing's sarcoma were collected from the Surveillance, Epidemiology, and End Results program database between 2004 and 2015 and further divided into training and validation cohort. Univariate and multivariate Cox regression analyses were used to identify meaningful independent prognostic factors. The nomogram was used to predict 3- and 5-year overall survival (OS) and cancer-specific survival (CSS). Finally, the nomogram was verified internally and externally through the training and validation cohorts, and the predictive capability was evaluated using the receiver operating characteristic (ROC) curve, C-index, and calibration curve and compared with that of the 7th TNM stage. A total of 1120 patients were divided into training (n = 713) and validation (n = 407) cohorts. Based on the multivariate analysis of the training cohort, a nomogram that integrated age, tumor size, primary site, N stage, and M stage was constructed (P < 0.05). The predicted C-indexes of OS and CSS of the training cohort were 0.744 (95% CI 0.717–0.771) and 0.743 (95% CI 0.715–0.770), respectively. However, the TNM stage had a C-index of 0.695 (95% CI 0.666–0.724) and 0.698 (95% CI 0.669–0.727) for predicting OS and CSS, respectively. The nomogram showed higher C-indexes than those in the TNM stage. Furthermore, the internal and external calibration curves showed good consistency between the predicted and observed values. Age, tumor size, primary site, N stage, and M stage are independent risk factors affecting the OS and CSS in Ewing’s sarcoma patients. Compared with the 7th TNM staging, the nomogram consisting of these factors was more accurate for risk assessment and survival prediction in patients with Ewing’s sarcoma, thus providing a novel reliable tool for risk assessment and survival prediction in Ewing’s sarcoma patients.
Circulating bile acids concentration is predictive of coronary artery disease in human
Authors: Chong Nguyen Caroline , Duboc Denis , Rainteau Dominique , Sokol Harry , Humbert Lydie , Seksik Philippe , Bellino Adèle , Abdoul Hendy , Bouazza Naïm , Treluyer Jean-Marc , Saadi Malika , Wahbi Karim , Soliman Heithem , Coffin Benoit , Bado André , Le Gall Maude , Varenne Olivier , Duboc Henri 
Published: November 2021

AbstractSynthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA). This prospective study examined whether variations in circulating BA are predictive of coronary artery disease (CAD) in human. Consecutive patients undergoing coronary angiography were enrolled. Circulating and fecal BA were measured by high pressure liquid chromatography and tandem mass spectrometry. Of 406 screened patients, 80 were prospectively included and divided in two groups with (n = 45) and without (n = 35) CAD. The mean serum concentration of total BA was twice lower in patients with, versus without CAD (P = 0.005). Adjusted for gender and age, this decrease was an independent predictor of CAD. In a subgroup of 17 patients, statin therapy doubled the serum BA concentration. Decreased serum concentrations of BA were predictors of CAD in humans. A subgroup analysis showed a possible correction by statins. With respect to the anti-atherosclerotic effect of BA in animal models, and their role in human lipid metabolism, this study describe a new metabolic disturbance associated to CAD in human.