bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the Genus Satureja as Food Supplement: Possible Modulation of the
Immune System via Intestinal Microbiota During SARS-CoV-2
Infection
Authors: Ezaouine Abdelkarim , Nouadi Badreddine , Sbaoui Yousra , El Messal Mariam , Chegdani Fatima , Bennis Faïza 
Published: December 2021

Abstract:
Satureja genus belongs to the Lamiaceae family, and they are used in food products and by pharmaceutical and cosmetic industries. The chemical composition of Satureja is responsible for its pharmacological and phytochemical properties. Among the various biological activities, notably antioxidant, antibacterial and antifungal, Satureja also has a potential antiviral activity. The exist-ence of a microbiota modulation potential by Satureja in farming animals has also been reported. Viral pathologies are one of the main causes of disease in the world. It is commonly known that gut microbiota plays a crucial role in the fight and progression of viral infection. Previous studies con-ducted on coronavirus disease 2019 (COVID-19) pandemic have proved an imbalance in the intes-tinal and pulmonary microbiota via gut-lung axis. Knowing the properties of Satureja and its tradi-tional use, one can suggest the possibility of using it as dietary supplement to modulate immune system in order to prevent and fight viral infections.
The objective of this review is to reveal the potential impact of medicinal plants such as Satureja genus as a food supplement, on immune enhancing during SARS-CoV-2 infection and their rela-tionships with the intestinal microbiota.
The Emerging Role of Nanosuspensions for Drug Delivery and Stability
Authors: Dewangan Hitesh Kumar 
Published: December 2021

:
Poor solubility of some medicinal compounds is a serious challenge that can be addressed
by using a nano-suspension for improved delivery. The nanoparticles enhance the bioavailability
along with the aqueous solubility of the drug, which is accomplished by increasing the active
surface area of the drug. The gained attention of the nanosuspension is due to its stabilization
facility, which is achieved by polymers, such as polyethylene glycol (PEG), having a particular
size range of 10 - 100 nm. Hence, these nanoparticles have the capacity of binding to the targeted
with very low damage to the healthy tissues. These are prepared by various methods, such as
milling, high-pressure homogenization, and emulsification, along with melt emulsification. Moreover,
surface modification and solidification have been used to add specific properties to the advanced
therapies as post-processing techniques. For many decades, it has been known that water
solubility hampers the bioavailability and not all drugs are water-soluble. In order to combat this
obstacle, nanotechnology has been found to be of specific interest. For elevating the bioavailability
by increasing the dissolution rate, the methodology of reduction of the associated drug particles into
their subsequent submicron range is incorporated. For oral and non-oral administration, these
nanosuspension formulations are used for the delivery of drugs.
Efficient Transport and Biotransformation of Dipeptide-like Tyrosine/
Phenylalanine-Conjugated Phenolic Amide Esters in THP-1 Cells
and PBMCs: A Potential Means for Transporting Compounds Inside
Monocytes/Macrophages
Authors: Park Jae B. 
Published: December 2021

Background:
Recent studies suggest that dipeptide-like tyrosine/phenylalanine-conjugated
phenolic amide compounds may contain several biological activities, including anti-inflammatory
activity. However, there is currently no information about their transport and biotransformation
in monocytes/macrophages involved in inflammation process.

Objective:
The objective of this study was to investigate cell transport and biotransformation of the
phenolic amides and esters in monocyte/macrophage-like cells.

Methods:
Cell transport and biotransformation of the phenolic amides and esters (N-coumaroylphenylalanine,
N-caffeoylphenylalanine, N-feruloylphenylalanine, N-coumaroyltyrosine, Ncaffeoyltyrosine,
N-feruloyltyrosine, and their O-methyl esters) were investigated in THP-1 cells
and PBMCs using HPLC, cellular, and kinetics methods.

Results:
In THP-1 cells, the phenolic amides were not transported significantly, but their O-methyl
esters were transported significantly (P < 0.02). Also, the transport of the esters was found to be
sodium-independent and pH-dependent. Among the tested esters, N-feruloylphenylalanine-Omethyl
ester showed the highest uptake (Km of 25 μM), and the uptake was inhibited by PepT1/2
substrate and blocker (GlySar and enalapril) in THP-1 cells. Particularly, enalapril competitively inhibited
the uptake with Ki of 560 μM. The data also showed that N-feruloylphenylalanine-Omethyl
ester and N-feruloyltyrosine-O-methyl ester could be biotransformed into parent phenolic
amides in THP-1 cells. Similarly, these ester compounds were also found to be transported and biotransformed
in PBMCs.

Conclusion:
The data suggest that dipeptide-like tyrosine/phenylalanine-conjugated phenolic
amide esters may be transported and biotransformed in THP-1 cells and PBMCs.
Text Mining of Adverse Events in Clinical Trials: Deep Learning Approach
Authors: Chopard Daphne , Treder Matthias S , Corcoran Padraig , Ahmed Nagheen , Johnson Claire , Busse Monica , Spasic Irena 
Published: December 2021

Background
Pharmacovigilance and safety reporting, which involve processes for monitoring the use of medicines in clinical trials, play a critical role in the identification of previously unrecognized adverse events or changes in the patterns of adverse events.

Objective
This study aims to demonstrate the feasibility of automating the coding of adverse events described in the narrative section of the serious adverse event report forms to enable statistical analysis of the aforementioned patterns.

Methods
We used the Uniﬁed Medical Language System (UMLS) as the coding scheme, which integrates 217 source vocabularies, thus enabling coding against other relevant terminologies such as the International Classification of Diseases–10th Revision, Medical Dictionary for Regulatory Activities, and Systematized Nomenclature of Medicine). We used MetaMap, a highly configurable dictionary lookup software, to identify the mentions of the UMLS concepts. We trained a binary classifier using Bidirectional Encoder Representations from Transformers (BERT), a transformer-based language model that captures contextual relationships, to differentiate between mentions of the UMLS concepts that represented adverse events and those that did not.

Results
The model achieved a high F1 score of 0.8080, despite the class imbalance. This is 10.15 percent points lower than human-like performance but also 17.45 percent points higher than that of the baseline approach.

Conclusions
These results confirmed that automated coding of adverse events described in the narrative section of serious adverse event reports is feasible. Once coded, adverse events can be statistically analyzed so that any correlations with the trialed medicines can be estimated in a timely fashion.
Depressive Symptoms and Anxiety During the COVID-19 Pandemic: Large, Longitudinal, Cross-sectional Survey
Authors: MacDonald James J , Baxter-King Ryan , Vavreck Lynn , Naeim Arash , Wenger Neil , Sepucha Karen , Stanton Annette L 
Published: December 2021

Background
The COVID-19 pandemic has influenced the mental health of millions across the globe. Understanding factors associated with depressive symptoms and anxiety across 12 months of the pandemic can help identify groups at higher risk and psychological processes that can be targeted to mitigate the long-term mental health impact of the pandemic.

Objective
This study aims to determine sociodemographic features, COVID-19-specific factors, and general psychological variables associated with depressive symptoms and anxiety over 12 months of the pandemic.

Methods
Nationwide, cross-sectional electronic surveys were implemented in May (n=14,636), July (n=14,936), October (n=14,946), and December (n=15,265) 2020 and March/April 2021 (n=14,557) in the United States. Survey results were weighted to be representative of the US population. The samples were drawn from a market research platform, with a 69% cooperation rate. Surveys assessed depressive symptoms in the past 2 weeks and anxiety in the past week, as well as sociodemographic features; COVID-19 restriction stress, worry, perceived risk, coping strategies, and exposure; intolerance of uncertainty; and loneliness.

Results
Across 12 months, an average of 24% of respondents reported moderate-to-severe depressive symptoms and 32% reported moderate-to-severe anxiety. Of the sociodemographic variables, age was most consistently associated with depressive symptoms and anxiety, with younger adults more likely to report higher levels of those outcomes. Intolerance of uncertainty and loneliness were consistently and strongly associated with the outcomes. Of the COVID-19-specific variables, stress from COVID-19 restrictions, worry about COVID-19, coping behaviors, and having COVID-19 were associated with a higher likelihood of depressive symptoms and anxiety.

Conclusions
Depressive symptoms and anxiety were high in younger adults, adults who reported restriction stress or worry about COVID-19 or who had had COVID-19, and those with intolerance of uncertainty and loneliness. Symptom monitoring as well as early and accessible intervention are recommended.
Integrating and Disseminating Pre-Exposure Prophylaxis (PrEP) Screening and Dispensing for Black Men Who Have Sex With Men in Atlanta, Georgia: Protocol for Community Pharmacies
Authors: Crawford Natalie D , Harrington Kristin R V , Alohan Daniel I , Sullivan Patrick S , Holland David P , Klepser Donald G , Quamina Alvan , Siegler Aaron J , Young Henry N 
Published: December 2021

Background
Black men who have sex with men (BMSM) suffer from alarmingly high rates of HIV in the United States. Pre-exposure prophylaxis (PrEP) can reduce the risk of HIV infection by 99% among men who have sex with men, yet profound racial disparities in the uptake of PrEP persist. Low PrEP uptake in BMSM is driven by poor access to PrEP, including inconvenient locations of PrEP-prescribing physicians, distrust of physicians, and stigma, which limit communication about PrEP and its side effects. Previous work indicates that offering HIV prevention services in pharmacies located in low-income, underserved neighborhoods is feasible and can reduce stigma because pharmacies offer a host of less stigmatized health services (eg, vaccinations). We present a protocol for a pharmacy PrEP model that seeks to address challenges and barriers to pharmacy-based PrEP specifically for BMSM.

Objective
We aim to develop a sustainable pharmacy PrEP delivery model for BMSM that can be implemented to increase PrEP access in low-income, underserved neighborhoods.

Methods
This study design is a pilot intervention to test a pharmacy PrEP delivery model among pharmacy staff and BMSM. We will examine the PrEP delivery model’s feasibility, acceptability, and safety and gather early evidence of its impact and cost with respect to PrEP uptake. A mixed-methods approach will be performed, including three study phases: (1) a completed formative phase with qualitative interviews from key stakeholders; (2) a completed transitional pilot phase to assess customer eligibility and willingness to receive PrEP in pharmacies during COVID-19; and (3) a planned pilot intervention phase which will test the delivery model in 2 Atlanta pharmacies in low-income, underserved neighborhoods.

Results
Data from the formative phase showed strong support of pharmacy-based PrEP delivery among BMSM, pharmacists, and pharmacy staff. Important factors were identified to facilitate the implementation of PrEP screening and dissemination in pharmacies. During the transitional pilot phase, we identified 81 individuals who would have been eligible for the pilot phase.

Conclusions
Pharmacies have proven to be a feasible source for offering PrEP for White men who have sex with men but have failed to reach the most at-risk, vulnerable population (ie, BMSM). Increasing PrEP access and uptake will reduce HIV incidence and racial inequities in HIV. Translational studies are required to build further evidence and scale pharmacy-based PrEP services specifically for populations that are disconnected from HIV prevention resources.

International Registered Report Identifier (IRRID)
DERR1-10.2196/35590
La alimentación-salud de las mujeres en el campo mexicano del siglo XXI: desafíos para la soberanía alimentaria desde una mirada decolonial feminista
Authors: Vizcarra Bordi Ivonne 
Published: December 2021

<span lang="ES-TRAD">El objetivo del artículo es recapacitar sobre algunas problemáticas sociales sobre la alimentación, y los fenómenos de transición nutricional y epidemiológica (TAN-E) que confrontan las mujeres del campo mexicano ante el avance del dominio capitalista en los sistemas agroalimentarios. Debido a la diversidad de contextos rurales que definen el campo mexicano, el escrito aborda una gran pregunta que guía la reflexión sobre los dilemas de tener acceso a los alimentos, alimentarse y alimentar sin poner en riesgo su salud: ¿la alimentación actual de las mujeres del campo mexicano compromete el resarcimiento de la soberanía alimentaria en términos del buen comer? Para responderla, se eligió el problema del sobrepeso y obesidad asociado con la malnutrición registrado en multicasos situados alimentarios. A través de una mirada decolonial, se analizan las narrativas dominantes capitalistas que han producido conocimientos de este problema, fortaleciendo la mercantilización de los procesos de vida, lo cual complica la liberación del patriciado y su instrumentalización que someten a las mujeres rurales, indígenas, campesinas a nuevas relaciones de poder. Al reconocer estas relaciones en los mecanismos o instrumentos de la razón que explican la TAN-E y sus efectos en la salud de las mujeres, el artículo rescata elementos que pueden contribuir a la formación de masa crítica femenina, y con ella podría elaborarse una propuesta de rescate de la soberanía alimentaria en su justa dimensión ética, amigable con la naturaleza, y promotora de una cultura de cuidado y paz.</span>
Bulimia nervosa: Assessment instruments for Spanish-speaking population / Bulimia nerviosa: Instrumentos de evaluación para población de habla hispana
Authors: Bautista-Díaz María Leticia , Amaya-Hernández Adriana , Ortega-Luyando Mayaro , Ortega-Andrade Norma Angélica 
Published: December 2021

De la población mundial 7.8% es hispanohablante, esto representa 567 millones de personas y se calcula que para 2050 esta cifra se elevará, además, el español es el segundo idioma de comunicación a nivel internacional; con este contexto y a casi cuatro décadas de la aparición formal de la Bulimia Nerviosa (BN), es necesario conocer cuáles y cómo son los instrumentos para evaluar los síntomas de la BN en este tipo de población. Por tanto, el objetivo de la presente investigación fue describir los cuestionarios para evaluar en población de habla hispana los síntomas de BN. Se encontró que México, cuenta con seis instrumentos; España con cinco; Colombia tiene tres instrumentos; Puerto Rico y Cuba cuentan con dos; Argentina, Costa Rica, Bolivia, El Salvador, Venezuela y República Dominicana, cuentan con uno. Estos pueden ser para el tamizaje de síntomas de la BN; o para evaluar los síntomas de la BN como parte de la evaluación de diversas dimensiones; o para evaluar a los familiares/cuidadores en el proceso de tratamiento de la BN. Se concluye que, es alentador que la población de habla hispana cuente con diversos cuestionarios adaptados y validados en su lengua para evaluar los síntomas de la BN.
Presentación
Authors: Franco-Paredes Karina 
Published: December 2021

El presente número de la Revista Mexicana de Trastornos Alimentarios/Mexican Journal of Eating Disorders tiene el propósito de presentar un análisis sobre las evidencias de confiabilidad y validez de las puntuaciones de los instrumentos de medida utilizados en la investigación y tratamiento de los trastornos de la conducta alimentaria y de la ingestión de alimentos (TAIA) en población hispano hablante. Para cumplir con este propósito el número está conformado por nueve revisiones narrativas sobre las propiedades psicométricas de los instrumentos más utilizados en este campo de estudio con la colaboración de autores de cinco países, España, Argentina, Chile, Estados Unidos y México.La medición es uno de los pilares en los que se sustenta el avance de una área de estudio. El nivel de precisión y validez de las puntuaciones de los instrumentos utilizados para medir las variables está relacionado con la fortaleza de las conclusiones. En el campo de los TAIA desde hace más de cuatro décadas se han desarrollado instrumentos siguiendo procesos rigurosos de construcción y evaluación permanente de su calidad métrica. Algunos instrumentos han sido revisados considerando los cambios en los criterios de diagnóstico de acuerdo con el Manual Diagnóstico y Estadístico de los Trastornos Mentales (DMS, por sus siglas en inglés). Se ha demostrado que son vigentes para la evaluación tanto de los síntomas como de las variables asociadas a estos trastornos y en algunos casos se ha evidenciado que es necesario realizar adaptaciones.Agradezco la colaboración de quienes contribuyeron en cada una de las nueve revisiones que conforman este número monográfico. Un agradecimiento especial a la Dra. Carme Viladrich, experta en psicometría, quien aceptó la invitación para escribir la editorial de este número. Sus aportaciones en el área de la psicometría y su interés por mejorar la evaluación de la calidad de las puntuaciones de los instrumentos de medida han inspirado la propuesta de este número monográfico. La rigurosidad de su análisis y honestidad intelectual han sido una guía importante para la realización de estudios instrumentales. Espero que el contenido de este número monográfico sirva para difundir el conocimiento sobre cómo fueron construidos los instrumentos y cómo se ha generado evidencia respecto a la validez y confiabilidad de sus puntuaciones en población hispano hablante. Así, los profesionales e investigadores podrán decidir sobre la utilización de un instrumento basándose en la evidencia empírica sobre su calidad métrica. Sin duda, también se tienen grandes áreas de oportunidad para continuar generando evidencia respecto a los instrumentos en esta área de estudio. Es necesario realizar una evaluación continua de las propiedades psicométricas incorporando los avances en el análisis de datos.
Ideologi Media dan Framing Pada Pemberitaan Perusakan Rumah Ibadah di Kompas dan Republika
Authors: Muthaqin Farid , Syam Hamdani M , Wahyuni Putri 
Published: December 2021

This study aims to find out how the framing in the news related to the destruction of the Musala in North Minahasa on the news of online media Kompas.com in the period 30 January to 13 February 2020 and Republika.co.id for the period 30 January 2020 to 12 February 2020. This study uses a qualitative method. descriptive analysis with framing analysis by Robert N. Entman with four elements, namely defining the problem, diagnosing the cause, making moral judgments, and recommending treatment. This study focuses on news about the destruction of the Musala that occurred in North Minahasa. The results show that the framing of the news presented by Kompas.com media is objectivity in reporting the case of the destruction of the Musala in North Minahasa, by not taking sides with certain groups, as well as in explaining that Kompas.com refrains from writing in a safe style, as well as a narrow news perspective. while Republika.co.id is more daring in conveying facts and news that are presented in depth and viewed from various perspectives so that it is possible to find the aspirations of Muslims to get the right to get a Musala as a place of worship. The difference in the frame of the two media is influenced by the ideological factors of each media. Even though they have different framing, these two media want the incident of vandalism of places of worship in North Minahasa to be resolved peacefully.
Analysis of magnetic field components anomalies due to homogeneous polyhedrons
Authors: Amarante Eduardo Menezes de Souza , Sampaio Edson Emanoel Starteri 
Published: December 2021

ABSTRACT. A procedure for determining semi-analytical expressions for the magnetic fields caused by homogeneous polyhedral bodies based on Green's theorem has been developed. It constitutes a modification of previous developments for the gravity field of three-dimensional bodies and employs the discretization of the faces of the polyhedron by triangles and the definition of local coordinates for each triangle. A maximum misfit of less than 1.0% between the values computed with these analytical expressions and those obtained with closed expressions for prismatic bodies, applied to a homogeneous cube, demonstrates the effectiveness of the procedure. Examples of magnetic maps due to octahedral bodies with different forms and orientations show that it is possible to obtain a qualitative distinction among their anomalies. Therefore, the present analysis constitutes a basis for future inverse modeling of convex polyhedrons and will be useful in geophysical exploration.Keywords: magnetic anomalies, polyhedral bodies, irregular shapes. Análise das componentes do campo magnético produzido por um poliedro homogêneoRESUMO. Foi desenvolvido um procedimento para determinar expressões analíticas para os campos magnéticos causados por corpos poliédricos homogêneos com base no teorema de Green. Constitui uma modificação dos desenvolvimentos anteriores para o campo gravitacional de corpos tridimensionais e emprega a discretização das faces do poliedro por triângulos e a definição das coordenadas locais para cada triângulo. Um erro máximo inferior a 1,0% entre os valores calculados com essas expressões analíticas e os obtidos com expressões fechadas para corpos prismáticos, aplicados a um cubo homogêneo, demonstra a eficácia do procedimento. Exemplos de mapas magnéticos devido a corpos octaédricos com diferentes formas e orientações mostram que é possível obter uma distinção qualitativa entre suas anomalias. Portanto, a presente análise constitui uma base para futura modelagem inversa de poliedros convexos e será útil na exploração geofísica.Palavras-chaves: anomalias magnéticas, corpos poliédricos, formas irregulares. How to cite:AMARANTE EMS & SAMPAIO EES. 2021. Analysis of magnetic field components anomalies due to homogeneous polyhedrons. Brazilian Journal of Geophysics, v. 39, n. 1. doi: 10.22564/rbgf.v38i3.2078