bluuebunny/crossref_metadata_2025_split huggingface dataset:
The physical activity paradox: a longitudinal study of the implications for burnout
Authors: de Vries Juriena D. , Bakker Arnold B. 
Published: October 2021

Abstract
Purpose
This study investigates the independent and interactive associations of physical job demands and three types of off-job physical activity (during transportation, household, and recreation) with burnout. We use a recently proposed new conceptualization and assessment of burnout including core and secondary burnout symptoms. We predicted that physical job demands would be positively and the three types of off-job physical activity would be negatively related to burnout. Further, we hypothesized that the negative relations between the three types of off-job physical activity and burnout would be stronger for employees with low (vs. high) physical job demands.

Methods
To test our hypotheses, we conducted a two-wave survey study among a heterogeneous sample of full-time workers (N = 355), using a longitudinal design with a half-year time lag. We tested cross-sectional, prospective and longitudinal relations.

Results
Hierarchical regression analyses partly confirmed our predictions. Cross-sectionally and prospectively, it was shown that physical job demands were positively related to burnout symptoms. In addition, off-job physical activity was negatively related to primary and secondary burnout symptoms among employees with low physical job demands and positively related to burnout symptoms among employees with high physical job demands. However, these relationships disappeared when investigated longitudinally.

Conclusion
Together, these findings suggest that not all off-job physical activities can prevent burnout, and that potential positive effects of physical activity during off-job time may depend on employees’ physical activity level at work.
Complement catalyzing glomerular diseases
Authors: Zipfel Peter F. , Wiech Thorsten , Gröne Hermann-Josef , Skerka Christine 
Published: October 2021

AbstractComplement is an evolutionarily conserved system which is important in the defense against microorganisms and also in the elimination of modified or necrotic elements of the body. Complement is activated in a cascade type manner and activation and all steps of cascade progression are tightly controlled and regulatory interleaved with many processes of inflammatory machinery. Overshooting of the complement system due to dysregulation can result in the two prototypes of primary complement mediated renal diseases: C3 glomerulopathy and thrombotic microangiopathy. Apart from these, complement also is highly activated in many other inflammatory native kidney diseases, such as membranous nephropathy, ANCA-associated necrotizing glomerulonephritis, and IgA nephropathy. Moreover, it likely plays an important role also in the transplant setting, such as in antibody-mediated rejection or in hematopoietic stem cell transplant associated thrombotic microangiopathy. In this review, these glomerular disorders are discussed with regard to the role of complement in their pathogenesis. The consequential, respective clinical trials for complement inhibitory therapy strategies for these diseases are described.
A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory bowel disease in Japan
Authors: Ando Katsuyoshi , Fujiya Mikihiro , Watanabe Kenji , Hiraoka Sakiko , Shiga Hisashi , Tanaka Shinji , Iijima Hideki , Mizushima Tsunekazu , Kobayashi Taku , Nagahori Masakazu , Ikeuchi Hiroki , Kato Shingo , Torisu Takehiro , Kobayashi Kiyonori , Higashiyama Masaaki , Fukui Toshiro , Kagaya Takashi , Esaki Motohiro , Yanai Shunichi , Abukawa Daiki , Naganuma Makoto , Motoya Satoshi , Saruta Masayuki , Bamba Shigeki , Sasaki Makoto , Uchiyama Kazuhiko , Fukuda Katsuyuki , Suzuki Hideo , Nakase Hiroshi , Shimizu Toshiaki , Iizuka Masahiro , Watanabe Mamoru , Suzuki Yasuo , Hisamatsu Tadakazu 
Published: October 2021

Abstract
Background
The mortality and risk factors of severe disease and death due to arterial and venous thromboembolism (ATE and VTE, respectively) in patients with inflammatory bowel disease (IBD) remain unclear, especially in Asia.

Aims
This study aimed to reveal the mortality and risk factors of TE in IBD patients in Japan.

Methods
In the primary surveillance, responses to questionnaires regarding the number of cases of severe TE and TE-associated death in IBD patients in a span of over the past 10 years were obtained from 32 institutions in Japan. In the secondary surveillance, detailed data about IBD patients with TE were collected. The characteristics, laboratory data, therapy status, and situation at the time of TE development were retrospectively collected, and the data were compared between the patients with and without severe TE and TE-associated death.

Results
The incidence of TE was 1.89% among 31,940 IBD patients. The frequencies of severe TE and TE-associated mortality were 10.7% and 1.0% among the total IBD and TE with IBD patients, respectively. The only risk factor for severe ATE and ATE-associated death was ischemic heart disease. The independent risk factors for severe VTE and VTE-associated death were age (≤ 45 years old), the site of VTE, and disease severity, with anti-TNF therapy as a potential negative risk factor. Patients with severe VTE had a high risk of developing persistent VTE and sequelae.

Conclusion
Unlike ATE, the incidence of VTE was comparable in Asian and Western countries. Therapeutic and prophylactic strategies for managing IBD-associated TE in Asia are urgently needed.
Predictors of postoperative urinary retention after posterior spinal fusion for adolescent idiopathic scoliosis
Authors: Yrjälä Tommi , Helenius Linda , Taittonen Markku , Oksanen Hanna , Keskinen Heli , Kolari Terhi , Helenius Ilkka 
Published: October 2021

Abstract
Purpose
To determine predictors for postoperative urinary retention in adolescents undergoing posterior spinal fusion for idiopathic scoliosis. Postoperative urinary retention affects almost every third adolescent after spinal fusion for idiopathic scoliosis. There are limited data regarding the risk factors of postoperative urinary retention in this patient group.

Methods
A retrospective study with prospectively collected urinary retention data from paediatric spine register with 159 consecutive patients (114 females, mean age 15.6 years, range 10–21 years) undergoing pedicle screw instrumentation for adolescent idiopathic scoliosis at a university hospital between May 2010 and April 2020. Postoperative urinary retention was defined as an inability to void after catheter removal and documented residual over 300 mL as confirmed using an ultrasound or by catheterization.

Results
Postoperative urinary retention was diagnosed in 33% (53 of 159) of the patients during hospital stay. Opioid amount on the day of catheter removal (OR 6.74 [95% CI: 2.47, 18.36], p < 0.001), male gender (OR 2.26 [95% CI: 1.01, 5.05], p = 0.048), and increasing weight (OR 1.04 [95% CI: 1.01, 1.07], p = 0.014) were associated with postoperative urinary retention. Mean opioid consumption on the day of catheter removal was 0.81 mg/kg (95% CI: 0.66, 0.96) in the retention group vs 0.57 mg/kg (95% CI: 0.51, 0.64) in the non-retention group, p < 0.001.

Conclusions
Higher total opioid consumption, opioid amount on the day of catheter removal, higher weight, and male gender increases the risk of postoperative urinary retention in adolescents with idiopathic scoliosis undergoing posterior spinal fusion.
Bridge technique for hemifacial spasm with vertebral artery involvement
Authors: Inoue Takuro , Shitara Satoshi , Goto Yukihiro , Arham Abrar , Prasetya Mustaqim , Radcliffe Lori , Fukushima Takanori 
Published: October 2021

Abstract

Background
To assess efficacy and safety of a newly developed decompression technique in microvascular decompression for hemifacial spasm (HFS) with vertebral artery (VA) involvement.

Methods
A rigid Teflon (Bard® PTFE Felt Pledget, USA) with the ends placed between the lower pons and the flocculus creates a free space over the root exit zone (REZ) of the facial nerve (bridge technique). The bridge technique and the conventional sling technique for VA-related neurovascular compression were compared retrospectively in 60 patients. Elapsed time for decompression, number of Teflon pieces used during the procedure, and incidences of intraoperative manipulation to the lower cranial nerves were investigated. Postoperative outcomes and complications were retrospectively compared in both techniques.

Results
The time from recognition of the REZ to completion of the decompression maneuvers was significantly shorter, and fewer Teflon pieces were required in the bridge technique than in the sling technique. Lower cranial nerve manipulations were performed less in the bridge technique. Although statistical analyses revealed no significant differences in surgical outcomes except spasm-free at postoperative 1 month, the bridge technique is confirmed to provide spasm-free outcomes in the long-term without notable complications.

Conclusions
The bridge technique is a safe and effective decompression method for VA-involved HFS.
Enzyme prodrug therapy: cytotoxic potential of paracetamol turnover with recombinant horseradish peroxidase
Authors: Humer Diana , Spadiut Oliver 
Published: October 2021

AbstractTargeted cancer treatment is a promising, less invasive alternative to chemotherapy as it is precisely directed against tumor cells whilst leaving healthy tissue unaffected. The plant-derived enzyme horseradish peroxidase (HRP) can be used for enzyme prodrug cancer therapy with indole-3-acetic acid or the analgesic paracetamol (acetaminophen). Oxidation of paracetamol by HRP in the presence of hydrogen peroxide leads to N-acetyl-p-benzoquinone imine and polymer formation via a radical reaction mechanism. N-acetyl-p-benzoquinone imine binds to DNA and proteins, resulting in severe cytotoxicity. However, plant HRP is not suitable for this application since the foreign glycosylation pattern is recognized by the human immune system, causing rapid clearance from the body. Furthermore, plant-derived HRP is a mixture of isoenzymes with a heterogeneous composition. Here, we investigated the reaction of paracetamol with defined recombinant HRP variants produced in E. coli, as well as plant HRP, and found that they are equally effective in paracetamol oxidation at a concentration ≥ 400 µM. At low paracetamol concentrations, however, recombinant HRP seems to be more efficient in paracetamol oxidation. Yet upon treatment of HCT-116 colon carcinoma and FaDu squamous carcinoma cells with HRP–paracetamol no cytotoxic effect was observed, neither in the presence nor absence of hydrogen peroxide.
Graphic abstract
Kombination geophysikalischer und hydrogeologischer Methoden zur gezielten Erkundung feinkörniger Talfüllungen
Authors: Klingler Stefan , Martin Simon , Cirpka Olaf A. , Dietrich Peter , Leven Carsten 
Published: October 2021

KurzfassungSedimentäre Strukturen können die Fließ- und Stofftransportpfade in feinkörnigen Talfüllungen stark beeinflussen. Diese Strukturen müssen gezielt auf ihre Ausdehnung und Eigenschaften untersucht werden, um Verweilzeiten, Fließpfade und das Abbaupotenzial eingetragener Schadstoffe zu bestimmen. In der quartären Talfüllung der Ammeraue bei Tübingen wurden beispielhaft Torflagen und eine Kiesrinne untersucht, um ihre Einflüsse auf die regionale Hydrogeologie und Hydrochemie zu bewerten. Dafür wurden geophysikalische und hydrogeologische Erkundungsmethoden ausgewählt und kombiniert. Mit geoelektrischen Oberflächenmessungen konnte die Ausdehnung der betrachteten Strukturen erkundet werden. Unterschiedliche Direct-Push-Sondierungen, darunter eine In-situ-Bestimmung der Sedimentfarbe, und bohrlochgeophysikalische Messungen erfassten ihre Geometrie und interne Heterogenität. Die hydraulischen und biogeochemischen Eigenschaften der Sedimente und des Grundwassers wurden anschließend durch gezielte Probennahmen und hydraulische Tests an repräsentativen Ansatzpunkten bestimmt. Die dargestellte Methodenkombination zur Abgrenzung relevanter Teilgebiete mit anschließender hochauflösender Untersuchung lässt sich auch auf die Untersuchung großflächiger Täler übertragen.
A transfer-learning approach for corrosion prediction in pipeline infrastructures
Authors: Canonaco Giuseppe , Roveri Manuel , Alippi Cesare , Podenzani Fabrizio , Bennardo Antonio , Conti Marco , Mancini Nicola 
Published: October 2021

AbstractPipeline infrastructures, carrying either gas or oil, are often affected by internal corrosion, which is a dangerous phenomenon that may cause threats to both the environment (due to potential leakages) and the human beings (due to accidents that may cause explosions in presence of gas leakages). For this reason, predictive mechanisms are needed to detect and address the corrosion phenomenon. Recently, we have seen a first attempt at leveraging Machine Learning (ML) techniques in this field thanks to their high ability in modeling highly complex phenomena. In order to rely on these techniques, we need a set of data, representing factors influencing the corrosion in a given pipeline, together with their related supervised information, measuring the corrosion level along the considered infrastructure profile. Unfortunately, it is not always possible to access supervised information for a given pipeline since measuring the corrosion is a costly and time-consuming operation. In this paper, we will address the problem of devising a ML-based predictive model for internal corrosion under the assumption that supervised information is unavailable for the pipeline of interest, while it is available for some other pipelines that can be leveraged through Transfer Learning (TL) to build the predictive model itself. We will cover all the methodological steps from data set creation to the usage of TL. The whole methodology will be experimentally validated on a set of real-world pipelines.
Regional based exposure models to account for local building typologies
Authors: Tocchi G. , Polese M. , Di Ludovico M. , Prota A. 
Published: October 2021

AbstractThe development of building inventory is a fundamental step for the evaluation of the seismic risk at territorial scale. Census data are usually employed for building inventory in large scale application and their use requires suitable rules to assign buildings typologies to vulnerability classes, that is an exposure model specific for the considered vulnerability model. Several exposure models are developed proposing class assignment rules that are calibrated on building typological data available from post-earthquake survey data. However, this approach has the drawback of being based on data from specific geographic areas that have been hit by damaging earthquakes. Indeed, the distribution of building typologies can vary greatly for different areas of a country and the diffusion of one building’s typology rather than another one may depend on the availability of construction material in the area, the evolution of construction techniques and the codes in force at the time of construction. This paper aims to improve the exposure modelling at regional scale, investigating the variability of masonry building typologies distribution. It proposes a methodology to recalibrate the exposure models at regional scale and evaluates the influence of the improved characterization of regional vulnerability on damage and risk assessment. The study shows that the analysis of local building typologies may strongly impact on the evaluation of the seismic risk at territorial scale.
Zerumbone acts as a radiosensitizer in head and neck squamous cell carcinoma
Authors: Schnoell Julia , Stanisz Isabella , Jank Bernhard J. , Stanek Victoria , Schmid Rainer , Brunner Markus , Heiduschka Gregor , Kotowski Ulana 
Published: October 2021

SummaryIntroduction. Zerumbone is a phytochemical compound of the ginger plant Zingiber zerumbet with cytotoxic effects in various cancer cell lines. To date, zerumbone has shown an antiproliferative effect in oral squamous cell carcinoma cells lines. However, the effect of combination with radiation or cisplatin in head and neck squamous cell carcinoma (HNSCC) is unclear. The aim of this study was to investigate the effect of zerumbone alone, and in combination with irradiation and cisplatin on HNSCC cell lines. Methods. The three HNSCC cell lines SCC25, Cal27 and FaDu were treated with zerumbone, radiation and/or cisplatin. Cell viability and clonogenic assays were performed. The interaction between zerumbone and radiation or cisplatin was evaluated using the combination index. Apoptosis was measured by flow cytometry and cell migration was assessed using a wound healing assay. Results. Treatment with zerumbone resulted in a dose dependent induction of cytotoxicity and apoptosis in all three cell lines. The combination with cisplatin revealed a synergistic to additive effect in Cal27. The clonogenic assay showed a significant radiosensitizing effect in all three cell lines. The wound healing assay showed a reduction of cell migration in Cal27. Conclusion. The natural compound zerumbone shows a cytotoxic and proapoptotic effect on HNSCC cell lines. Furthermore, zerumbone enhances the radiation effect in all three cell lines and thus may be a suitable candidate for combination therapy in HNSCC.
Blockchain technology in the smart city: a bibliometric review
Authors: Rejeb Abderahman , Rejeb Karim , Simske Steven J. , Keogh John G. 
Published: October 2021

AbstractBlockchain can function as a foundational technology with numerous applications in smart cities. The objective of this paper is twofold. First, it provides a detailed overview of the extant literature on blockchain applications in smart cities; second, it reveals the trends and suggests future research directions for scholars who wish to contribute to this rapidly growing field. We conducted a bibliometric review using a keyword co-occurrence network and article co-citation analysis. The analysis includes the assessment of 148 articles published between 2016 and 2020 in 76 academic journals. The review results demonstrate that the number of articles devoted to the study of blockchain applications and smart cities has increased exponentially in recent years. More importantly, the research identifies some of the most influential studies in this area. The paper discusses trends and highlights the challenges related to the deployment of blockchain in smart cities. To the authors’ best knowledge, this represents the first study to review the literature from leading journals on blockchain applications in smart cities using bibliometric techniques.
Arbitrage-free Nelson–Siegel model for multiple yield curves
Authors: Brignone Riccardo , Gerhart Christoph , Lütkebohmert Eva 
Published: October 2021

AbstractWe propose an affine term structure model that allows for tenor-dependence of yield curves and thus for different risk categories in interbank rates, an important feature of post-crisis interest rate markets. The model has a Nelson–Siegel factor loading structure and thus economically well interpretable parameters. We show that the model is tractable in terms of estimation and provides good in-sample fit and out-of-sample forecasting performance. The proposed model is arbitrage-free across maturities and tenors, and thus perfectly suited for risk management and pricing purposes. We apply our framework to the pricing of caplets in order to illustrate its practical applicability and its suitability for stress testing.
A Melt Pool Temperature Model in Laser Powder Bed Fabricated CM247LC Ni Superalloy to Rationalize Crack Formation and Microstructural Inhomogeneities
Authors: Wang Di , Li Sheng , Deng Guowei , Liu Yang , Attallah Moataz M. 
Published: October 2021

Abstract
This study of the laser powder bed fusion (LPBF) of γ′-strengthened Ni superalloy CM247LC focuses on the development of a melt pool temperature model to predict crack density within the alloy. This study also analyzes spatter and elemental evaporation, which might cause defects and inhomogeneities, at different melt pool temperatures. The melt pool temperature model provides more accurate predictions than the widely used energy density model. Spatter particles were collected and characterized to study their sizes and chemical compositions, compared with the virgin powder, recycled powder, and as-built samples, to probe the impact of their entrapment into the melt pool. This study also investigated Al evaporation, revealing that its extent does not correlate with the laser energy density and is believed to be rather limited by comparing the chemistry of the virgin powder and the build. Last, the impact of LPBF process parameters on the formation of these inhomogeneities, and accordingly crack formation, was studied using finite element analysis by estimating the maximum melt pool temperature and correlating it with the formation of the microstructural inhomogeneities. The morphology of the various cracking modes was associated with the process parameters.
Optoelectrical Operation Stability of Broadband PureGaB Ge-on-Si Photodiodes with Anomalous Al-Mediated Sidewall Contacting
Authors: Krakers Max , Knežević Tihomir , Nanver Lis K. 
Published: October 2021

AbstractAn anomalous aluminum-mediated material transport process was investigated in sets of Ge-on-Si photodiodes with broadband optoelectrical characteristics measured at wavelengths from 255 nm to 1550 nm. The diodes had “PureGaB” anode regions fabricated by depositing a Ga wetting layer capped with an 11-nm-thick B-layer on 0.5 µm-thick Ge islands grown on Si. The Al metallization was able to reach the Ge-Si interface through ~ 0.1-µm-wide holes inadvertently etched along the perimeter of the Ge-islands, and then traveled along the Ge-Si interface, displacing and recrystallizing Ge and Si. The rest of the Ge surface was protected from the Al contact metallization by the B-layer. For diodes that had received the standard 400°C Al alloying step, the responsivity was near-theoretical at 406 nm and 670 nm, but, at 1310 nm and 1550 nm, the proximity of Ge-Si interfacial defects caused significant attenuation. Extra annealing at 400°C or 500°C enhanced the formation of Si pits that were filled with modified Ge crystals alloyed with Si andp-doped with Al. All these diodes maintained low dark currents, below 50 µA/cm2at 2 V reverse bias, but the responsivity was degraded, particularly for the long wavelengths. On the other hand, neither responsivity nor degradation of current–voltage (I–V) characteristics was observed for prolonged exposure to normal operating temperatures up to 100°C. Since the direct Al contacting of the Ge sidewalls does not degrade the dark current, for large diodes it could be a low-cost method of obtaining low contact resistance to an anode withp-type sidewall passivation and high fill-factor.
Subtypen der Insomnie – exemplarische Ansätze und offene Fragen
Authors: Spiegelhalder Kai , Benz Fee , Feige Bernd , Riemann Dieter 
Published: October 2021

ZusammenfassungVerschiedene Autorinnen und Autoren nehmen an, dass es klinisch nützlich und wissenschaftlich erkenntnisbringend sein könnte, Subtypen der Insomnie zu identifizieren, um diese spezifisch und damit möglicherweise effektiver zu behandeln, als dies derzeit geschieht. Im vorliegenden Beitrag werden folgende exemplarisch ausgewählte Ansätze zur Einteilung der Insomnie in Subtypen vorgestellt: 1) Einteilungen nach klinischen Symptomen; 2) Primäre vs. sekundäre Insomnie; 3) Subtypen nach ICSD‑2; 4) Insomnie mit und ohne objektiv messbare kurze Schlafdauer; 5) Subtypen aus der Netherlands Sleep Registry. Anschließend werden die Stabilität der Zuordnung von einzelnen Patienten zu den verschiedenen Subtypen sowie die klinische Relevanz der Einteilungen kritisch diskutiert.