bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homeopathic treatment of two patients with coronary artery disease: case-report
Authors: Scala Pedro Bernardo 
Published: December 2021

The homeopathic materia medica includes a number of remedies potentially useful in heart diseases and that could be an effective complementary tool in cardiology and cardiovascular surgery. As conventional doctors demand evidence on the efficacy and effectiveness of homeopathic treatment backed with independent laboratory evaluation by accredited specialists, this paper reports the outcome of two patients diagnosed with severe coronary artery disease treated with homeopathic remedies. Keywords: coronary artery disease; low dilutions remedies. Ãƒâ€šÃ‚Â Tratamento de 2 pacientes com doenÃƒÆ’Ã‚Â§as na artÃƒÆ’Ã‚Â©ria coronária: relato de caso ResumoA MatÃƒÆ’Ã‚Â©ria MÃƒÆ’Ã‚Â©dica homeopática inclui uma sÃƒÆ’Ã‚Â©rie de medicamentos potencialmente ÃƒÆ’Ã‚Âºteis para doenÃƒÆ’Ã‚Â§as cardíacas, que poderiam ser efetivos como ferramenta complementar na cardiologia e cirurgia cardiovascular. A medicina tradicional exige a obtenÃƒÆ’Ã‚Â§ÃƒÆ’Ã‚Â£o de evidéncias sobre a eficácia e efetividade de tratamentos homeopáticos, suportadas por resultados de laboratÃƒÆ’Ã‚Â³rios independentes e acreditados por especialistas. Este artigo relata o acompanhamento de 2 pacientes diagnosticados com doenÃƒÆ’Ã‚Â§a severa da artÃƒÆ’Ã‚Â©ria coronária , tratados com medicamentos homeopáticos. Palavras-chave: doenÃƒÆ’Ã‚Â§a da artÃƒÆ’Ã‚Â©ria coronariana, medicamentos dinamizados. Ãƒâ€šÃ‚Â Tratamiento homeopático de dos pacientes con enfermedad arterial coronaria: informe de caso ResumenLa materia mÃƒÆ’Ã‚Â©dica homeopática incluye una serie de recursos potencialmente ÃƒÆ’Ã‚Âºtiles en las enfermedades del corazÃƒÆ’Ã‚Â³n y que podría ser una eficaz herramienta complementaria en cardiología y cirugía cardiovascular. Considerando la demanda por pruebas sobre la eficacia y la eficacia del tratamiento homeopático, con respaldo en laboratorios independiente y evaluaciÃƒÆ’Ã‚Â³n por especialistas acreditados, el presente documento informa de los resultados de dos pacientes con diagnÃƒÆ’Ã‚Â³stico de grave enfermedad de la arteria coronaria tratada con remedios homeopáticos. Palabras-clave: enfermedad de las arterias coronarias; bajas diluciones recursos Ãƒâ€šÃ‚Â Correspondence author: Pedro Bernardo Scala, pedroscala@gmail.com How to cite this article: Scala PB. Homeopathic treatment of two patients with coronary artery disease: case-report. Int J High Dilution Res [online]. 2009 [cited YYYY Month dd]; 8 (27): 45-49. Available from: http://journal.giri-society.org/index.php/ijhdr/article/view/337/391. Ãƒâ€šÃ‚Â
أثر الاستخدام المتكامل للسماد الإحيائي و الكيميائي على إنتاجية الفول المصري (Vicia faba L.)‎ في السودان
Authors: الشيخ عبد الغني ,جلال عثمان,أحمد محمد الحسن مقدام , عوض ,  دغيم، 
Published: December 2021

أثر الاستخدام المتكامل للسماد الإحيائي و الكيميائي على إنتاجية الفول المصري (Vicia faba L.)‎ في السودان
أجريت ثلاثة تجارب حقلية في موسم 2007 / 2008م في المزارع التجريبية لهيئة البحوث الزراعية في كل من منطقة دنقلا و الحديبة و شندي لدراسة أثر استخدام أسمدة إحيائية (بكتيريا الرايزوبيم-سلالةENRRI 9 و / أو البكتيريا المذيبة للفسفور-الفسفوباكترين) و كيميائية (يوريا 46% N+ فوسفور 48% P2O5) منفردة و متكاملة على إنتاجية محصول الفول المصري (الصنف حديبة72 ).
تم ترتيب المعاملات حسب تصميم القطاعات الكاملة العشوائية في أربع مكررات.
توصلت النتائج إلى أن التسميد ببكتريا الرايزوبيم منفردة أو متكاملة مع الفسفوباكترين أدى إلى زيادة معنوية في متوسط إنتاجية الفول المصري مقارنة بالشاهد لمنطقة دنقلا، في حين أن التسميد بالفسفوباكترين لوحدة أدى إلى زيادة معنوية في متوسط الإنتاجية في كل من منطقتي دنقلا و الحديبة.
أوضحت النتائج أن التسميد الكيميائي بمفرده أدى إلى زيادة معنوية في متوسط إنتاجية الفول المصري مقارنة بالشاهد في منطقتي دنقلا و الحديبة.
أظهرت النتائج أن زراعة الفول المصري في المناطق الثلاث ذات عائد مجد اقتصاديا.
حيث أعطى التسميد المتكامل ببكتريا الرايزوبيم و الفسفوباكترين أعطي أعلى معدل ربح في منطقة دنقلا، أما في منطقة الحديبة كان أعلى معدل ربح عند التسميد ببكتريا الرايزوبيم، بينما في منطقة شندي كان أعلى معدل ربح عند التسميد المتكامل بالفسفوباكترين و السماد الكيميائي.
أشارت النتائج الى أن أعلى ربحية يمكن الحصول عليها عند استخدام الأسمدة الإحيائية الكيميائية.
Synthesis of chalcone with mannich side chain iv
Authors: M,Anwar E. M. Nur,Sad M. H.  ,Jan H. Van Der,Himat M. Abd al-Karim,.  al-Jaleed,   Ayyub, Westhuizen,  Fadl,  A. 
Published: December 2021

Synthesis of chalcone with mannich side chain iv

مركب 3-هيدروكسي -4- ميثوكسي جالكون تم تحضيره بتفاعل 3- هيدروكسي بنزلدهيد مع 4- هيدروكسي اسيتوفينون.
الامينو مثيلة لهذا المركب تمت بمفاعلة الفورمالدهيد و الامين المناسب في الاسيتونيتر ايل تم تخليق : 4- هيدروكسي --4 ميثوكسي -3، 5- ثناي–ميثيل أمينو ميثايل جالكون (2)، 4-هيدروكسي -4- ميثوكسي -5، 3- بيرولدينو ميثايل جالكون (3)، 4- هيدروكسي -4- ميثوكسي -3، 5- بيبريدينوميثايل جالكون (4).
تمت تنقية المركبات النهاية و الوسيطة عن طريق كروموتوغرافيا الطبقة الرقيقة و كروموتوغرافا العمود.
تم التعرف عليها و مركباتها الوسطية عن طريق تحليل طيفي كامل شمل طيف الأشعة فوق البنفسجية، و طيف الأشعة الحمراء و طيف الرنين المغنطيسي و طيف الكتلة.
O drama Existencial de Brás Cubas: aproximações filosóficas em Memórias Póstumas de Brás Cubas, O Discurso de Metafísica de Leibniz e O Cândido de Voltaire
Authors: Araújo Eleno Marques de , Cruvinel Maria Eduarda Martins , Almeida Lara Mamede , Souza Victor Rodrigues de 
Published: December 2021

O objetivo deste texto é demonstrar que nas três obras indicadas para análise há um elo entre filosofia e literatura. Aqui seguimos a metodologia da revisão bibliográfica. Em uma segunda abordagem pretendemos tratar mais especificamente do Humanitismo, a teoria filosófica de Quincas Borba. Por ora, nos ocuparemos de demonstrar que filosofia e literatura estão em entrelaçadas por retratar dimensões do conhecimento humano e que caracterizam uma linguagem de questionamento e exposição de pensamento de forma concreta. Ambas buscam aspectos sólidos de discussão de vários significados possíveis para questões humanísticas. Tal abordagem une as obras: Memórias póstumas de Brás Cubas de Machado de Assis, O Discurso de Metafísica de Leibniz e Cândido de Voltaire. Assis deixa transparecer em sua obra que conhecia as obras filosóficas de Leibniz e Voltaire. Quincas Borba, o fundador do Humanitismo, o princípio de todas as coisas, emanando de Humanistas. Ao morrer afirmava que a dor é uma ilusão, e os ensinamentos dados a Cândido, por Pangloss, tinham razão de ser. Pois apesar da dor e do sofrimento a realidade da vida sempre é a melhor de todas as situações. Com tal convicção Quincas aponta para uma conclusão: a certeza de Leibniz que “este é o melhor dos mundos possíveis”.
Earthquake swarm activity in south Gujarat
Authors: RAO D. T. , JAMBUSARIA B. B. , SRIVASTAVA SANJAY , SRIVASTAVA N. P. , HAMID ABDUL , DESAI B.N. , SRIVASTAVA H.N. 
Published: December 2021

South Gujarat, a part of western coast of Indian Peninsula started experiencing earth tremors of mild intensity since early February 1986. The shocks were widely felt with rumbling sound in these areas. More than 23000 micro earthquakes have since been recorded tilt December 1988, with a major event, ML=4.6 which occurred on.27 April.1986: In view of the location of multi-purpose projects like Ukai, Damanganga, .Jhuj, Kflia etc the monitoring this activity was Immediately started through a network of seven temporary- microearthquake recording stations. This was followed by various other studies such as geodetic, geomagnatic, radon gas monitoring and temperature measurements 9f hot springs. The Unai and Mola-Amba hot springs situated in this area have indicated the temperature of about 57oC and 37°C respectively against the normal atmospheric temperature of 33o C.

The analysis by Hypo- 71 program on IBM computer of India Met. Dep., New Delhi, using a velocity model Koyna region has shown a well concentrated seismic activity over area of 7x 10 km2 and focal depth of 1-15 km. Clear migration of the activity has been observed. The activity which concentrated around Kella dam m early February-April 1986 migrated up to 18km to its south and back again to the religion around Kelia reservoir, by September 1987 with depth of foci progressively becoming shallower towards north .The 'b" value of 1.04 is higher than that of a few tectonic sequences of Peninsular India. The rate of decay of the activity was 0.52 which is rather slow compared to other sequences of the region. Hence, the reactivation of the existing fracturies/lineaments might be responsible or the recent activity. The geomagnetic studies in this area have corroborated tile existence of NW-SE to NNE-SSW trending conductive fractures. The earthquake activity during 1988 is quite low compared to earlier years.
Effects OF Mulligan’s Mobilization With Movement On First Rib To Reduce Pain And Improve Cervical Rotation In Mechanical Neck Dysfunction
Authors: Ahmad Irfan , Riaz Saima , Faiz Uzma , Sulaman Muhammad , Zeeshan Muhammad , Manzoor Tabassum 
Published: December 2021

Mechanical Neck Pain(MNP) is a term used to describe pain that results from stress or strain on the structures of the vertebral column. Factors such as alteration in the anatomical structures, sprain or strain of the muscles or ligaments, and adaptation to a faulty posture can result in First rib dysfunction has been identiﬁed as a potential cause for faulty dynamic, static, traumatic or congenital factors, may contribute to the development of elevated ﬁrst rib dysfunction. Objective: Was to determine the effects of Mulligan’s mobilization with movement on first rib to reduce pain and improve cervical rotation in mechanical neck dysfunction. Material and methods: This study Quasi-experimental trial was done at PT CARE MM Alam road Lahore. The study was completed within the time duration of six months (July-Dec 2019) after the approval of synopsis. A total of 26 cases (13 in each group) were divided into 2 groups. Group A and Group B were treated with conventional exercise program and with Mulligan’s mobilization with movement on first rib and conventional exercise program only respectively. Bubble inclinometer and NPRS tools were used to measure cervical rotation and Pain respectively. Data analysis was done by SPSS 21.
Results: The mean change in NPRS was statistically higher in group-B (5.46 ± 0.78) as compared to group-A (2.62 ± 0.87), p-value < 0.001. The mean change in cervical rotation (ROM) was statistically higher in group-B (17.46 ± 5.19) as compared to group-A (31.23 ± 4), p-value < 0.001. Conclusion: It is concluded that Mulligan’s mobilization with movement on first rib and conventional exercise program had statistically significant change in reduction of pain and had higher improvement in cervical rotation (ROM) right and left. Hence, by combining conventional treatment and Mulligan’s mobilization , maximum clinical benefits to reduce pain and improve cervical rotation can be attained in mechanical neck dysfunction
Dinámica espacio-temporal de la producción camaronera en la isla Puná del cantón Guayaquil, provincia de Guayas
Authors: Juela Oscar , Romero Martha , Burneo Iván , Zury Willam , González Aníbal , Ramírez Manuel 
Published: December 2021

En la Isla Puná, provincia de Guayas, la actividad camaronera ha venido desarrollándose desde la década de los 80’s, con cultivos de tipo extensivos. En los últimos años, esta industria se ha ampliado a considerables superficies, dejando como secuela la pérdida de grandes extensiones de bosques de manglar, pasando por alto la importancia ecológica que tienen dichos bosques. En este contexto, en la presente investigación se busca determinar el cambio de uso del suelo y su cuantificación, mediante la recolección, procesamiento y clasificación, por el método supervisado de imágenes satelitales en cuatro periodos de tiempo utilizando los algoritmos de máxima verosimilitud y máxima secuencialidad a posteriori. Para verificar la fiabilidad de los datos obtenidos se elaboró una matriz de confusión y, con ello, se obtuvo el estadístico Kappa. Los resultados demostraron que la producción camaronera incrementó su superficie de 6 819,30 ha, en 1985, a 13 832,01 ha en 2016, una dinámica que ha generado pérdida de los bosques de manglar, los cuales disminuyeron de 10 931,31 ha, en 1985, a 5 282,82 ha en 2016. Esto representó la pérdida neta de superficies manglar de 5 648,49 ha y la ganancia neta de la actividad camaronera de 7 012,71 ha.
Determinantes do Empreendedorismo Feminino no Brasil e Regiões
Authors: Rosa Samanda Silva da , Orellana Vivian dos Santos Queiroz , Menezes Gabrielito Rauter 
Published: December 2021

O objetivo deste trabalho é verificar os determinantes do empreendedorismo feminino no Brasil e em suas cinco regiões usando os microdados da Pesquisa Nacional por Amostra de Domicílios (PNAD) do ano de 2015. O maior desafio relacionado a esse tema ´e compreender quais são os fatores que levam a mulher a se tornar empreendedora ou não. O procedimento de tomada de decisão individual considera diferentes fatores, sendo alguns destes sociais, demográficos e regionais. A estratégia empírica adotada foi um modelo probit para a estimação da escolha ocupacional. Os resultados sugerem que a probabilidade de a mulher empreender aumenta para a raça branca, idade, anos de estudos iniciais, chefe do domicílio, idade dos filhos, imigrante de retorno e com o aumento das horas dedicadas aos afazeres domésticos.
Problemática de estudio en el caso de los retratos de El- Fayum
Authors: Caravaca Guerrero Consuelo Isabel 
Published: December 2021

The mummification process of the ancient Egyptians has created great myths about this civilization but the process of creating the mummies was not immutable throughout the entire history of Egypt. Such is so, that before El-Fayum's portraits we find ourselves facing the best example in which three great civilisations converge, such as Egypt, Greece and Rome, in the same space-time framework. Nevertheless, this fact has meant a grievance as for its conservation, not having a clear answer about which researchers were better prepared to study them. Another one of the most outstanding peculiarities of these portraits, is the pictorial technique used, the great information it give us about the physical aspect of the mummy and even the social position they occupied, since until the appearance of these portraits, not everyone could afford a funeral in which its remains were mummified.
El proceso de momificación de los antiguos egipcios ha creado grandes mitos acerca de esta civilización pero no durante toda la historia de Egipto el proceso de creación de las momias fue inmutable. Tal es así, que ante los retratos de El- Fayum nos encontramos frente al mejor ejemplo en el que convergen tres grandes civilizaciones, como son Egipto, Grecia y Roma, en un mismo marco espacio-temporal. Sin embargo, este hecho ha significado un agravio a la hora de su conservación, al no tener claro que investigadores estarían mejor preparados para estudiarlas. Otras de las peculiaridades más destacadas de estos retratos, son la técnica pictórica utilizada, la gran información que nos aportan sobre el aspecto físico de la momia e incluso la posición social a la que pertenecían ya que hasta la aparición de estos retratos, no todo el mundo podía permitirse un sepelio en el que sus restos fuesen momificados.
MACROECONOMIC BUSINESS ENVIRONMENT AND THE DEVELOPMENT OF SMALL AND MEDIUM ENTERPRISES IN NIGERIA
Authors: Oladimeji Moruff Sanjo , Sofoluwe Nurudeen Afolabi , Odunaya Henry Adewale 
Published: December 2021

The study evaluates the effect of the global macro-economic business environment on the development of Small-Scale and Medium-Sized Enterprises (SMEs) in Nigeria. Secondary data on the global macro-economic index of SMEs businesses were selected over 35 years (1985–2019). The data collected were analysed using descriptive statistics and multiple regression analysis techniques. The study revealed the positive coefficient value of 354 836.6525 and 24 141 873.6 for the gross domestic product (GDP) on Purchasing Power Parity (PPP) and Budget variables. A negative coefficient value of –16347085.61 and –232997.0657 was obtained for the inflation rate and the exchange rate, respectively. The coefficient values show the level at which the development of SMEs businesses was affected through the global environmental factors. The study concluded that the global macro-economic business environment directly affects the development of SMEs businesses. The study recommends a policy strategy that will face out the global macro-economic constraints affecting SMEs businesses.
Advanced In Vitro Lung Models for Drug and Toxicity Screening: The Promising Role of Induced Pluripotent Stem Cells
Authors: Moreira Anabela , Müller Michelle , Costa Pedro F. , Kohl Yvonne 
Published: December 2021

AbstractThe substantial socioeconomic burden of lung diseases, recently highlighted by the disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the need for interventive treatments capable of decelerating disease progression, limiting organ damage, and contributing to a functional tissue recovery. However, this is hampered by the lack of accurate human lung research models, which currently fail to reproduce the human pulmonary architecture and biochemical environment. Induced pluripotent stem cells (iPSCs) and organ‐on‐chip (OOC) technologies possess suitable characteristics for the generation of physiologically relevant in vitro lung models, allowing for developmental studies, disease modeling, and toxicological screening. Importantly, these platforms represent potential alternatives for animal testing, according to the 3Rs (replace, reduce, refine) principle, and hold promise for the identification and approval of new chemicals under the European REACH (registration, evaluation, authorization and restriction of chemicals) framework. As such, this review aims to summarize recent progress made in human iPSC‐ and OOC‐based in vitro lung models. A general overview of the present applications of in vitro lung models is presented, followed by a summary of currently used protocols to generate different lung cell types from iPSCs. Lastly, recently developed iPSC‐based lung models are discussed.
Printed Organic Electrochemical Transistors for Detecting Nutrients in Whole Plant Sap
Authors: Strand Elliot J. , Bihar Eloise , Gleason Sean M. , Han Sanggil , Schreiber Samuel W. , Renny Megan N. , Malliaras George G. , McLeod Robert R. , Whiting Gregory L. 
Published: December 2021

AbstractLow‐cost biosensors that can rapidly and widely monitor plant nutritional levels will be critical for better understanding plant health and improving precision agriculture decision making. In this work, fully printed ion‐selective organic electrochemical transistors (OECTs) that can detect macronutrient concentrations in whole plant sap are described. Potassium, the most concentrated cation in the majority of plants, is selected as the target analyte as it plays a critical role in plant growth and development. The ion sensors demonstrate high current (170 µA dec−1) and voltage (99 mV dec−1) sensitivity, and a low limit of detection (10 × 10−6 m). These OECT biosensors can be used to determine potassium concentration in raw sap and sap‐like aqueous environments demonstrating a log‐linear response within the expected physiological range of cations in plants. The performance of these printed devices enables their use in high‐throughput plant health monitoring in agricultural and ecological applications.
Discrete Stacked Dimers of Aromatic Oligoamide Helices
Authors: Bindl Daniel , Mandal Pradeep K. , Allmendinger Lars , Huc Ivan 
Published: December 2021

AbstractTight binding was observed between the C‐terminal cross section of aromatic oligoamide helices in aqueous solution, leading to the formation of discrete head‐to‐head dimers in slow exchange on the NMR timescale with the corresponding monomers. The nature and structure of the dimers was evidenced by 2D NOESY and DOSY spectroscopy, mass spectrometry and X‐ray crystallography. The binding interface involves a large hydrophobic aromatic surface and hydrogen bonding. Dimerization requires that helices have the same handedness and the presence of a C‐terminal carboxy function. The protonation state of the carboxy group plays a crucial role, resulting in pH dependence of the association. Dimerization is also influenced by neighboring side chains and can be programmed to selectively produce heteromeric aggregates.
Rituximab Impairs B Cell Response But Not T Cell Response to COVID‐19 Vaccine in Autoimmune Diseases
Authors: Bitoun Samuel , Henry Julien , Desjardins Delphine , Vauloup‐Fellous Christelle , Dib Nicolas , Belkhir Rakiba , Mouna Lina , Joly Candie , Bitu Marie , Ly Bineta , Pascaud Juliette , Seror Raphaèle , Roque Afonso Anne‐Marie , Le Grand Roger , Mariette Xavier 
Published: December 2021

ObjectiveAntibody response to the messenger RNA (mRNA) COVID‐19 vaccine has been shown to be diminished in rituximab (RTX)–treated patients. We undertook this study to compare humoral and T cell responses between healthy controls, patients with autoimmune diseases treated with RTX, and those treated with other immunosuppressants, all of whom had been vaccinated with 2 doses of the mRNA COVID‐19 vaccine.MethodsWe performed anti‐spike IgG and neutralization assays just before and 28 days after the second BNT162b2 (Pfizer‐BioNTech) vaccine dose. The specific T cell response was assessed in activated CD4 and CD8 T cells using intracellular flow cytometry staining of cytokines (interferon‐γ, tumor necrosis factor, and interleukin‐2) after stimulation with SARS–CoV‐2 spike peptide pools.ResultsA lower proportion of responders with neutralizing antibodies to the vaccine was observed in the RTX group (29%; n = 24) compared to the other immunosuppressants group (80%; n = 35) (P = 0.0001) and the healthy control group (92%; n = 26) (P < 0.0001). No patients treated with RTX in the last 6 months showed a response. Time since last infusion was the main factor influencing humoral response in RTX‐treated patients. The functional CD4 and CD8 cellular responses to SARS–CoV‐2 peptides for each single cytokine or polyfunctionality were not different in the RTX group compared to the other immunosuppressants group or the control group. In RTX‐treated patients, the T cell response was not different between patients with and those without a humoral response.ConclusionRTX induced a diminished antibody response to the mRNA COVID‐19 vaccine, but the functional T cell response was not altered compared to healthy controls and autoimmune disease patients treated with other immunosuppressants. Further work is needed to assess the clinical protection granted by a functionally active T cell response in the absence of an anti‐spike antibody response.