bluuebunny/crossref_metadata_2025_split huggingface dataset:
In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice
Authors: Cahill Kerin M. , Gartia Manas R. , Sahu Sushant , Bergeron Sarah R. , Heffernan Linda M. , Paulsen Daniel B. , Penn Arthur L. , Noël Alexandra 
Published: September 2021

AbstractApproximately 7% of pregnant women in the United States use electronic-cigarette (e-cig) devices during pregnancy. There is, however, no scientific evidence to support e-cig use as being ‘safe’ during pregnancy. Little is known about the effects of fetal exposures to e-cig aerosols on lung alveologenesis. In the present study, we tested the hypothesis that in utero exposure to e-cig aerosol impairs lung alveologenesis and pulmonary function in neonates. Pregnant BALB/c mice were exposed 2 h a day for 20 consecutive days during gestation to either filtered air or cinnamon-flavored e-cig aerosol (36 mg/mL of nicotine). Lung tissue was collected in offspring during lung alveologenesis on postnatal day (PND) 5 and PND11. Lung function was measured at PND11. Exposure to e-cig aerosol in utero led to a significant decrease in body weights at birth which was sustained through PND5. At PND5, in utero e-cig exposures dysregulated genes related to Wnt signaling and epigenetic modifications in both females (~ 120 genes) and males (40 genes). These alterations were accompanied by reduced lung fibrillar collagen content at PND5—a time point when collagen content is close to its peak to support alveoli formation. In utero exposure to e-cig aerosol also increased the Newtonian resistance of offspring at PND11, suggesting a narrowing of the conducting airways. At PND11, in females, transcriptomic dysregulation associated with epigenetic alterations was sustained (17 genes), while WNT signaling dysregulation was largely resolved (10 genes). In males, at PND11, the expression of only 4 genes associated with epigenetics was dysregulated, while 16 Wnt related-genes were altered. These data demonstrate that in utero exposures to cinnamon-flavored e-cig aerosols alter lung structure and function and induce sex-specific molecular signatures during lung alveologenesis in neonatal mice. This may reflect epigenetic programming affecting lung disease development later in life.
State of the art review of new technologies in spine deformity surgery–robotics and navigation
Authors: Sielatycki J. Alex , Mitchell Kristen , Leung Eric , Lehman Ronald A. 
Published: September 2021

Abstract
Study design/methods
Review article.

Objectives
The goal of this article is to review the available evidence for computerized navigation and robotics as an accuracy improvement tool for spinal deformity surgery, as well as to consider potential complications, impact on clinical outcomes, radiation exposure, and costs.

Summary of background data/results
Pedicle screw and rod construct are widely utilized for posterior spinal fixation in spinal deformity correction. Freehand placement of pedicle screws has long been utilized, although there is variable potential for inaccuracy depending on surgeon skill and experience. Malpositioned pedicle screws may have significant clinical implications ranging from nerve root irritation, inadequate fixation, CSF leak, perforation of the great vessels, or spinal cord damage. Computer-based navigation and robotics systems were developed to improve pedicle screw insertion accuracy and consistency, and decrease the risk of malpositioned pedicle fixation. The available evidence suggests that computer-based navigation and robotic-assisted guidance systems for pedicle cannulation are at least equivalent, and in several reports superior, to freehand techniques in terms of accuracy. CT and robotic navigation systems do appear to decrease radiation exposure to the operative team in some reports. Published reports do indicate longer operative times with use of robotic navigation compared with traditional freehand techniques for pedicle screw placement. To date, there is no conclusive evidence that use of CT or robotic navigation has any measurable impact on patient outcomes or overall complication reduction. There are theoretical advantages with robotic and CT navigation in terms of both speed and accuracy for severe spinal deformity or complex revision cases, however, there is a need for studies to investigate this technology in these specific cases. There is no evidence to date demonstrating the cost effectiveness of CT or robotic navigation as compared with traditional pedicle cannulation techniques.

Conclusions
The review of available evidence suggests that computer-based navigation and robotic-assisted guidance systems for pedicle cannulation are at least equivalent, and in several reports superior, to freehand techniques in terms of radiographic accuracy. There is no current clinical evidence that the use of navigation or robotic techniques leads to improved patient outcomes or decreased overall complications or reoperation rates, and the use of these systems may substantially increase surgical costs.

Level of evidence
V.
Cost Analysis of Screening Programmes for Developmental Dysplasia of the Hip: A Systematic Review
Authors: Harper Philip , Gangadharan Rohit , Poku Daryl , Aarvold Alexander 
Published: September 2021

Abstract
Aims
The aim of this study was to assess screening costs in developmental dysplasia of the hip (DDH), to provide any clarity on the cost-effectiveness of various hip screening programmes internationally.

Methods
A PROSPERO-registered systematic review was performed by examining cost analysis studies of various DDH screening programmes, including those based around clinical examination, selective ultrasound and universal ultrasound. Costs were analysed using narrative synthesis.

Results
There were 14 studies included in this review. Two studies found that clinical hip screening is advantageous over no screening at all, both in terms of overall cost and favourable outcomes. When considering selective ultrasound imaging versus clinical screening, two studies found it to be more expensive, one found it cheaper and three studies calculated the overall programme costs to be similar. With universal ultrasound, four studies calculated this to be cheaper than clinical or selective ultrasound screening due to a reduced late detection and surgery rate. However, a comparable number of studies concluded that the increased financial costs of universal ultrasound were greater than the reduction in surgical costs. No studies included any long-term data.

Conclusion
There is a dearth of information on DDH screening costs, with significant heterogeneity amongst the existing literature. Future research should include the cost analysis of long-term complications of DDH, including the social and psychological impact of early onset arthritis, as well as gender specific ultrasound screening programmes.
Investigating the practical viability of walk-sharing in improving pedestrian safety
Authors: Bhowmick Debjit , Winter Stephan , Stevenson Mark , Vortisch Peter 
Published: September 2021

AbstractWalk-sharing is a cost-effective and proactive approach that promises to improve pedestrian safety and has been shown to be technically (theoretically) viable. Yet, the practical viability of walk-sharing is largely dependent on community acceptance, which has not, until now, been explored. Gaining useful insights on the community’s spatio-temporal and social preferences in regard to walk-sharing will ensure the establishment of practical viability of walk-sharing in a real-world urban scenario. We aim to derive practical viability using defined performance metrics (waiting time, detour distance, walk-alone distance and matching rate) and by investigating the effectiveness of walk-sharing in terms of its major objective of improving pedestrian safety and safety perception. We make use of the results from a web-based survey on the public perception on our proposed walk-sharing scheme. Findings are fed into an existing agent-based walk-sharing model to investigate the performance of walk-sharing and deduce its practical viability in urban scenarios.
Female education, marital assortative mating, and dowry: Theory and evidence from districts of India
Authors: Agarwal Goel Prarthna , Barua Rashmi 
Published: September 2021

AbstractWe study marital assortative mating in education and its relation to dowry in India. There are four main results and contributions of this paper. First, instrumental variable estimates using Indian Human Development Survey-II data suggest existence of positive assortative mating in education levels of husband and wife. Second, this association is weaker in dowry-prominent districts suggesting that in districts with strong patriarchal norms, high dowry transfers could substitute for lower bride's education. Third, we study the independent effect of husband's and wife's education and its interaction on dowry. Estimates suggest that dowry rises with the groom's education and falls with the bride's schooling years. However, the joint effect of husband-and-wife education on dowry is negative, implying that though dowry rises with groom's education, the rate of increase is smaller the more educated the bride is. Finally, to explain the empirical results, we propose a theoretical model of assortative mating in the presence of dowry.
Trends in beta-hemolytic Streptococcus infections within Veterans’ Affairs medical centers from 2009 to 2018
Authors: Yam GiGi , Wattengel Bethany A. , Carter Michael T. , Sellick John A. , Lesse Alan J. , Mergenhagen Kari A. 
Published: September 2021

AbstractObjective:The purpose of this study was to describe the recent trends of invasive and noninvasive β-hemolytic Streptococcus cultures in the Veterans’ Affairs (VA) cohort from 2009 to 2018.Design:Retrospective cohort study from January 1, 2009, to January 1, 2019.Setting:Veterans’ Affairs medical centers.Patients or participants:All patients aged 18 years and older with cultures positive for β-hemolytic Streptococcus at a VA facility were included in the study.Intervention(s):Data were retrieved from the VA Corporate Data Warehouse using structure query language through the SQL Server Management Studio software.Results:Between 2009 and 2018, there were 40,625 patients with cultures with β-hemolytic Streptococcus. The median age was 64 years (interquartile range [IQR], 55–71) and the median Charlson comorbidity index was 4 (IQR, 2–7). Distributions for each type of β-hemolytic Streptococcus based on site of culture are provided. The 30-day all-cause mortality rate from all invasive β-hemolytic Streptococcus cases was 2.3%, and the 90-day all-cause mortality rate was 4.4%. The 30- and 90-day all-cause mortality rates for Streptococcus cases were higher for group A (3.9% and 6.1% respectively) and for groups C and G combined (3.2% and 6.1%, respectively) than for group B (2.0% and 4.0%, respectively).Conclusions:Trends of cultures for invasive and noninvasive β-hemolytic Streptococcus suggest an association with disease and mortality. The burden associated with β-hemolytic Streptococcus infections should not be underestimated.
Accounting for uncertainty from zero inflation and overdispersion in paleoecological studies of predation using a hierarchical Bayesian framework
Authors: Smith Jansen A. , Handley John C. , Dietl Gregory P. 
Published: September 2021

AbstractThe effects of overdispersion and zero inflation (e.g., poor model fits) can result in misinterpretation in studies using count data. These effects have not been evaluated in paleoecological studies of predation and are further complicated by preservational bias and time averaging. We develop a hierarchical Bayesian framework to account for uncertainty from overdispersion and zero inflation in estimates of specimen and predation trace counts. We demonstrate its application using published data on drilling predators and their prey in time-averaged death assemblages from the Great Barrier Reef, Australia.Our results indicate that estimates of predation frequencies are underestimated when zero inflation is not considered, and this effect is likely compounded by removal of individuals and predation traces via preservational bias. Time averaging likely reduces zero inflation via accumulation of rare taxa and events; however, it increases the uncertainty in comparisons between assemblages by introducing variability in sampling effort. That is, there is an analytical cost with time-averaged count data, manifesting as broader confidence regions. Ecological inferences in paleoecology can be strengthened by accounting for the uncertainty inherent to paleoecological count data and the sampling processes by which they are generated.
The impact of superconductivity and the Hall effect in models of magnetised neutron stars
Authors: Sur Ankan , Haskell Brynmor 
Published: September 2021

AbstractEquilibrium configurations of the internal magnetic field of a pulsar play a key role in modelling astrophysical phenomena from glitches to gravitational wave emission. In this paper, we present a numerical scheme for solving the Grad–Shafranov equation and calculating equilibrium configurations of pulsars, accounting for superconductivity in the core of the neutron star, and for the Hall effect in the crust of the star. Our numerical code uses a finite difference method in which the source term appearing in the Grad–Shafranov equation, which is used to model the magnetic equilibrium is non-linear. We obtain solutions by linearising the source and applying an under-relaxation scheme at each step of computation to improve the solver’s convergence. We have developed our code in both C++ and Python, and our numerical algorithm can further be adapted to solve any non-linear PDEs appearing in other areas of computational astrophysics. We produce mixed toroidal–poloidal field configurations, and extend the portion of parameter space that can be investigated with respect to previous studies. We find that in even in the more extreme cases, the magnetic energy in the toroidal component does not exceed approximately 5% of the total. We also find that if the core of the star is superconducting, the toroidal component is entirely confined to the crust of the star, which has important implications for pulsar glitch models which rely on the presence of a strong toroidal field region in the core of the star, where superfluid vortices pin to superconducting fluxtubes.
Potato consumption is not associated with elevated cardiometabolic risk in adolescent girls
Authors: Yiannakou Ioanna , Yuan Mengjie , Pickering Richard Taylor , Singer Martha R. , Moore Lynn L. 
Published: September 2021

AbstractWe examined the association between potato consumption in two different age periods during adolescence and risk of obesity and cardiometabolic dysfunction in White and Black girls. We used data from the biracial prospective National Growth and Health Study. Average potato consumption was derived from multiple 3-d food records in two age periods, 9–11 and 9–17 years, and included white and sweet potatoes from all sources. Multivariable logistic regression models were used to estimate OR for becoming overweight, developing prehypertension, elevated TAG levels or impaired fasting glucose (IFG) at 18–20 years of age according to the category of daily potato intake. We also stratified by cooking method (fried/non-fried) and race. ANCOVA was also used to estimate adjusted mean levels of BMI, systolic blood pressure, diastolic blood pressure, log-transformed TAG, the TAG:HDL ratio and fasting glucose levels associated with potato intake category. Higher potato consumption was associated with higher fruit and non-starchy vegetable intakes and higher Healthy Eating Index scores in Black girls. There were no statistically significant associations overall between moderate or higher (v. lower) intakes of potatoes and risks of overweight, prehypertension, elevated fasting TAG, high TAG:HDL ratio or IFG. Also, no adverse associations were found between fried or non-fried potato intake and cardiometabolic outcomes. Potato consumption has been the subject of much controversy in recent years. This study adds evidence that potato consumption among healthy girls during the critical period of adolescence was not associated with cardiometabolic risk.
Anthropometry, body composition and chronic disease risk factors among Zambian school-aged children who experienced severe malnutrition in early childhood
Authors: Kasonka Lackson , Munthali Grace , Rehman Andrea Mary , Chisenga Molly , Wells Samuel , Wells Jonathan C. K. , Filteau Suzanne 
Published: September 2021

AbstractThere is limited information as to whether people who experience severe acute malnutrition (SAM) as young children are at increased risk of overweight, high body fat and associated chronic diseases in later life. We followed up, when aged 7–12 years, 100 Zambian children who were hospitalised for SAM before age 2 years and eighty-five neighbourhood controls who had never experienced SAM. We conducted detailed anthropometry, body composition assessment by bioelectrical impedance and deuterium dilution (D2O) and measured blood lipids, Hb and HbA1c. Groups were compared by linear regression following multiple imputation for missing variables. Children with prior SAM were slightly smaller than controls, but differences, controlling for age, sex, socio-economic status and HIV exposure or infection, were significant only for hip circumference, suprailiac skinfold and fat-free mass index by D2O. Blood lipids and HbA1c did not differ between groups, but Hb was lower by 7·8 (95 % CI 0·8, 14·7) g/l and systolic blood pressure was 3·4 (95 % CI 0·4, 6·4) mmHg higher among the prior SAM group. Both anaemia and high HbA1c were common among both groups, indicating a population at risk for the double burden of over- and undernutrition and associated infectious and chronic diseases. The prior SAM children may have been at slightly greater risk than the controls; this was of little clinical significance at this young age, but the children should be followed when older and chronic diseases manifest.
First complete mitochondrial genome of Rhodinia species (Lepidoptera: Saturniidae): genome description and phylogenetic implication
Authors: Chen Dong-Bin , Zhang Ru-Song , Jin Xiang-Dong , Yang Jian , Li Peng , Liu Yan-Qun 
Published: September 2021

AbstractTo explore the characteristics of the mitochondrial genome (mitogenome) of the squeaking silkmoths Rhodinia, a genus of wild silkmoths in the family Saturniidae of Lepidoptera, and reveal phylogenetic relationships, the mitogenome of Rhodinia fugax Butler was determined. This wild silkmoth spins a green cocoon that has potential significance in sericulture, and exhibits a unique feature that its larvae can squeak loudly when touched. The mitogenome of R. fugax is a circular molecule of 15,334 bp long and comprises 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and an A + T-rich region, consistent with previous observations of Saturniidae species. The 370-bp A + T-rich region of R. fugax contains no tandem repeat elements and harbors several features common to the Bombycidea insects, but microsatellite AT repeat sequence preceded by the ATTTA motif is not present. Mitogenome-based phylogenetic analysis shows that R. fugax belongs to Attacini, instead of Saturniini. This study presents the first mitogenome for Rhodinia genus.
Molecular phylogenetic relationships of Metastrongylus nematodes with emphasis on specimens from domestic pigs in Vietnam
Authors: Tuyen N.V. , Lan N.T.K. , Doanh P.N. 
Published: September 2021

Abstract
Lungworms of the genus Metastrongylus are parasitic nematodes in the respiratory tract of swine. Although they infect both wild boars and domestic pigs, studies on Metastrongylus infections in wild boars in Europe, the Americas and Africa are numerous, while those in domestic pigs are few. There are several studies analysing the molecular phylogenetic relationships of few individual Metastrongylus species with other nematode taxa, but there are no studies on the phylogenetic relationships of species within the genus Metastrongylus. In Southeast Asia, reports on swine lungworms are extremely scarce and do not include any nucleotide sequence data. Therefore, the aim of the present study is to survey Metastrongylus infection in domestic pigs raised in Dien Bien Province, Northern Vietnam, and to analyse the molecular phylogenetic relationships of Metastrongylus species. Based on morphological and molecular data, we identified two species: Metastrongylus apri and Metastrongylus pudendotectus. The prevalence of the former species was found to be significantly higher than the latter one (24.1% vs. 2.3%). We observed pigs exhibiting a coinfection with the two lungworm species or a single infection with only M. apri. However, we did not observe any pigs being infected with just M. pudendotectus. Vietnamese Metastrongylus specimens showed slight morphological and molecular differences compared to those from other countries. The molecular analyses revealed a close genetic relationship between M. apri and Metastrongylus salmi, while both these species were far distant from M. pudendotectus. The present study highlights the needs for further studies to clarify the morphological features and ecological and phylogenetic relationships of Metastrongylus species at the global scale.
IMPLICIT LANGUAGE APTITUDE: CONCEPTUALIZING THE CONSTRUCT, VALIDATING THE MEASURES, AND EXAMINING THE EVIDENCE
Authors: Li Shaofeng , DeKeyser Robert 
Published: September 2021

AbstractThis article discusses the conceptualization, measurement, and validity of a recently emerged construct in the field of second language acquisition (SLA)—implicit language aptitude (alternatively “implicit aptitude”). Implicit aptitude is a set of cognitive abilities that enable learners to make unconscious computations of the distributional and transitional probabilities of linguistic input. Implicit aptitude is key to an accurate understanding of the cognitive foundation of language learning and contributes significantly to the advancement of SLA theory and pedagogy. The article starts by clarifying the concept and components of implicit aptitude, elaborating its role in SLA theories, identifying its attributes, and discussing its measurement. It then synthesizes the empirical evidence on its divergent, convergent, and predictive validity, which refers to whether it is distinct or separable from explicit aptitude, whether measures of implicit aptitude are correlated, and whether it is predictive of learning outcomes, respectively. Next, the article provides an overview of the seven empirical studies included in this special issue that examined implicit aptitude from various perspectives. The article concludes by identifying future directions.
WHY IS THE COMPONENTIAL CONSTRUCT OF IMPLICIT LANGUAGE APTITUDE SO DIFFICULT TO CAPTURE?
Authors: Perruchet Pierre 
Published: September 2021

AbstractAlthough this special issue reveals some promising achievements, most of the contributions show that tasks of implicit learning are not or are only weakly correlated with each other, and they have inconsistent predictive power on L2 acquisition. This commentary examines four possible explanations for this surprising pattern: The (suboptimal) selection of tasks, the low reliability of measures, the deep influence of the starting level even for nominally “new” implicit tasks, and the fact that the mastery of L2 may involve other implicit processes than implicit learning measured through laboratory tasks.