bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and biochemical parameters in adults with chronic heart failure
Authors: Gorący Iwona , Rębacz-Maron Ewa , Korbecki Jan , Gorący Jarosław 
Published: November 2021

Background
The study investigated the relationship between the concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and biochemical parameters in the blood serum of patients with heart failure (HF) and the potential influence on the development and progression of HF.

Material & methods
The study included 214 patients (155 men and 59 women), aged 40–87 years, presenting symptoms or signs typical of HF (according to the NYHA functional classification). Serum concentrations were determined for Mg, Ca, Fe, Cu, Zn, P, C-reactive protein (CRP), creatinine, urea, triglyceride levels (TG), total cholesterol (CH), high density protein (HDL), low density protein (LDL). The levels of macro-and microminerals were analysed using inductively coupled serum optical emission spectrometry (ICP-OES).

Results
Our study confirmed the role of known risk factors in the development of heart failure, including: overweight, diabetes, hypertension, high triglycerides (TG), high total cholesterol (CH), high levels of low density protein (LDL) and reduced levels of high density protein (HDL), high CRP, high creatinine. Moreover, deficient serum concentrations of Mg (47% of the studied men and 54% of the women) and Cu (in 44% of men and more than 30% of women) were observed, as well as subnormal serum Fe (2% of women) and Zn (1% of men). Elevated serum Ca was found in 50% of men and 49% of women. In 44% of the studied men and 52% of the studied women, P levels in serum were also above-average. The study revealed a significant positive correlation between serum levels of Ca and Mg, and also Ca and Cu in women. In men, serum Cu was positively correlated with Mg and Ca concentrations. In patients from group 1 (NYHA I–II), Mg content was positively correlated with Ca and Cu. In this patient group, Ca was also positively associated with Cu content in serum. In group 2 (NYHA III-IV), serum Mg concentration was significantly positively correlated with that of Cu and Ca.

Conclusions
Changes in the serum concentrations of macro-and microminerals may significantly affect the severity of HF in Polish patients.
The Effect of System Quality, Information Quality and Service Quality Towards Customer Loyalty Using Mobile Banking Application
Authors: Mahendra Muhammad A. , Winarno Wahyu A. , Kustono Alwan S. 
Published: November 2021

Aims/ Objectives: This study aims to examine the effect of system quality, information quality and service quality on customer loyalty with satisfaction as a moderating variable for users of the mobile banking application of Bank BRI Jember Branch.
Study Design: Quantitative Research
Place and Duration of Study: This research was conducted between March 2021 to May 2021. The research location is Bank BRI Jember Branch.
Methodology: The data in this study used a questionnaire distributed to customers of Bank BRI Jember Branch in the use of mobile banking applications. In this study, quota sampling technique was used to determine the number of samples taken, namely 390 customers of Bank BRI Jember Branch.
Results: The system quality variable (X1) has a p value of 0.005 on customer loyalty through customer satisfaction, quality information (X2) has a p value of 0.003 on customer loyalty through customer satisfaction and the service quality variable (X3) has a p value of 0.405. Meanwhile, customer satisfaction (Y) has a p value of 0.127 on customer loyalty.
Conclusion: This study rejects H1, H2 and H3 namely system quality (X1), information quality (X2) and service quality (X3) which directly have no effect on customer loyalty (Z) and accept H4 directly, customer satisfaction has a significant effect. significant to customer loyalty. While indirectly the quality of the system (X1) and the quality of information (X2) have a significant effect on customer loyalty (Z) through variables that affect customer satisfaction (Y) which means that it supports hypotheses H5 and H6. In contrast to service quality (X3) which has no significant effect on customer loyalty (Z) through customer satisfaction (Y).
Profitability of Using Commercial Tilapia Feed to Produce Three Different Sizes of Nile Tilapia (Oreochromis niloticus L.) Fingerlings in Ghana
Authors: Anani F. A. , Agbeko E. , Atsakpo P. D. K. , Johnson-Ashun M. , Osei L. K. , Donkor K. K. , Ayarika A. F. , Danquah E. 
Published: November 2021

Aims: To determine the profitability of using a commercial tilapia feed to produce three different size ranges (1.0-1.9, 2.0-2.9 and 5.0-5.9 g) of Nile tilapia, Oreochromis niloticus fingerlings in hapa-in-pond system.
Study Design: Completely randomized design.
Place and Duration of Study: The Aquaculture Research and Development Centre (ARDEC), Akosombo, of Water Research Institute (WRI) of Council for Scientific and Industrial Research (CSIR), Ghana, from March to May, 2020.
Methodology: Fish growth study was carried out in three (3) fine mesh netting hapas, each of dimensions 5.0 x 2.0 x 1.2 m. Nile tilapia fry at initial mean weight 0.03 ± 0.01 g were stocked at a density of 50 fish m-2 and they were fed at 20 % body weight five times daily. The feeding of the fish continued until those in all the 3 hapas attained a mean weight of at least 5.0 g. Then the experiment was terminated and all the survived fish in each hapa were harvested, counted, and their individual body weights were measured. Growth performance indicators and profitability of producing the various size categories (1.0-1.9, 2.0-2.9 and 5.0-5.9) were determined.
Results: The fry attained the target size ranges of 1.0-1.9, 2.0-2.9 and 5.0-5.9 g in 4, 6 and 9 weeks respectively. There were significant differences (ANOVA, P = 0.03) among final mean weights, weight gains, feed intakes, daily weight gains, feed efficiencies and harvested biomass among all size ranges, with those of 5.0-5.9 g being significantly higher (Tukey’s HSDT, P < 0.02). Sizes of fingerlings produced correlate positively with cost of feed used. The profit indices ranged from 2.57 to 10.22, with the highest recorded in the 1.0-1.9 g fingerlings and the least in those of 5.0-5.9 g.
Conclusion: The results indicated that, at the current Nile tilapia fingerlings cost and the time taken to produce the various size categories, the 1.0-1.9 g production is the most profitable.
Graphene‐Paper‐Based Electrodes on Plastic and Textile Supports as New Platforms for Amperometric Biosensing
Authors: Poletti Fabrizio , Scidà Alessandra , Zanfrognini Barbara , Kovtun Alessandro , Parkula Vitaliy , Favaretto Laura , Melucci Manuela , Palermo Vincenzo , Treossi Emanuele , Zanardi Chiara 
Published: November 2021

AbstractThe possibility of exfoliating graphite into graphene sheets allows the researchers to produce a material, termed “graphene paper” (G‐paper), conductive as graphite but more flexible and processable. G‐paper is already used for electronic applications, like conductors, antennas, and heaters, outperforming metal conductors thanks to its high flexibility, lightness, chemical stability, and compatibility with polymeric substrates. Here, the effectiveness in the use of G‐paper for the realization of electrodes on flexible plastic substrates and textiles, and their applicability as amperometric sensors are demonstrated. The performance of these devices is compared with commercial platforms made of carbon‐based inks, finding that they outperform commercial devices in sensing nicotinamide adenine dinucleotide (NADH), a key molecule for enzymatic biosensing; the electrodes can achieve state‐of‐the‐art sensitivity (107.2 μA mm−1 cm−2) and limit of detection (0.6 × 10−6 m) with no need of additional functionalization. Thanks to this property, the stable deposition of a suitable enzyme, namely lactate dehydrogenase, on the electrode surface is used as a proof of concept of the applicability of this new platform for the realization of a biosensor. The possibility of having a single material suitable for antennas, electronics, and now sensing opens new opportunities for smart fabrics in wearable electronic applications.
Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase
Authors: Mehanny Mina , Kroniger Tobias , Koch Marcus , Hoppstädter Jessica , Becher Dörte , Kiemer Alexandra K. , Lehr Claus‐Michael , Fuhrmann Gregor 
Published: November 2021

AbstractStreptococcus pneumoniae infections are a leading cause of death worldwide. Bacterial membrane vesicles (MVs) are promising vaccine candidates because of the antigenic components of their parent microorganisms. Pneumococcal MVs exhibit low toxicity towards several cell lines, but their clinical translation requires a high yield and strong immunogenic effects without compromising immune cell viability. MVs are isolated during either the stationary phase (24 h) or death phase (48 h), and their yields, immunogenicity and cytotoxicity in human primary macrophages and dendritic cells have been investigated. Death‐phase vesicles showed higher yields than stationary‐phase vesicles. Both vesicle types displayed acceptable compatibility with primary immune cells and several cell lines. Both vesicle types showed comparable uptake and enhanced release of the inflammatory cytokines, tumor necrosis factor and interleukin‐6, from human primary immune cells. Proteomic analysis revealed similarities in vesicular immunogenic proteins such as pneumolysin, pneumococcal surface protein A, and IgA1 protease in both vesicle types, but stationary‐phase MVs showed significantly lower autolysin levels than death‐phase MVs. Although death‐phase vesicles produced higher yields, they lacked superiority to stationary‐phase vesicles as vaccine candidates owing to their similar antigenic protein cargo and comparable uptake into primary human immune cells.
Defect Enrichment in Near Inverse Spinel Configuration to Enhance the Persistent Luminescence of Fe3+
Authors: Zhou Zhihao , Zhang Shuai , Le Yakun , Ming Hong , Li Yang , Ye Shi , Peng Mingying , Qiu Jianrong , Dong Guoping 
Published: November 2021

AbstractSpinel configuration is a kind of broadly considered host candidate when designing persistent luminescence (PersL) materials due to the easy generation of vacancies and anti‐site defects. Here, a new strategy of defect enrichment for the activation of PersL is proposed, and in contrast to the spinel configuration, it is demonstrated that the crystal structure of near inverse spinel ensures more numerous defects to activate the near‐infrared (NIR) PersL of Fe3+. Fe3+‐doped MgGa2O4 displays the PersL band in the range of 600 to 900 nm and possesses a super‐long PersL duration time >15 h. The optical analysis and the calculation of density functional theory unravel that the near inverse spinel structure can lower the carrier transfer barriers to accelerate the formation of carrier trap states within the bandgap. Therefore, more numerous defects in this structure may participate in the trapping and de‐trapping process by comparison with the normal spinel configuration. These findings are expected to accelerate the development of new PersL materials through Fe3+ doping toward versatile biological applications in NIR window.
Top‐Illuminated Organic Photodetectors beyond 1000 nm Wavelength Response Enabled by a Well‐Defined Interfacial Engineering
Authors: Wu Jhao‐Lin , Lai Lai‐Hung , Hsiao Yu‐Tang , Tsai Kuen‐Wei , Yang Chi‐Ming , Sun Zi‐Wan , Hsieh Jin‐Chiuan , Chang Yi‐Ming 
Published: November 2021

AbstractNear infrared (NIR) and shortwave infrared (SWIR) image technologies are of interest for many emerging applications. Among photodetector technologies, organic photodetectors (OPDs) are groundbreaking light sensors with unique photon‐to‐electron responses at various wavelengths that offer limitless flexibility in field applications due to the tunable design of organic semiconductors. Herein, a top‐illuminated OPD deposited on bottom aluminum electrode with a spectral response beyond a wavelength of 1000 nm is reported, which suggests a feasibility for image sensors integrated with bottom readout circuit. The results reveal that a device composed of aluminum‐doped zinc oxide, nickel oxide, and indium‐doped zinc oxide as hole blocking layer, hole transporting layer, and transparent top electrode, respectively, shows the best performance at a wavelength of ≈1000 nm, achieving an outstanding external quantum efficiency of 74% with a responsivity of 0.64 A W−1 and a detectivity of 6.6 × 1012 Jones. The device also performs a fast photocurrent response time of 9.8 µs and a linear dynamic range of 98 dB. To the best of knowledge, this device performance is one of the best reported to date for NIR and SWIR OPDs. The values are also comparable to commercially available inorganic photodetectors.
Extrusion foaming behavior of polybutene‐1. Toward single‐material multifunctional sandwich structures
Authors: Doyle Lucía 
Published: November 2021

AbstractPolymeric foams are a key element of many multifunctional sandwich structures. The most commonly used polymeric foam, polyurethane, presents environmental drawbacks, related to poor recyclability and the use of toxic diisocyanates for their manufacturing. The separation of layers in sandwich structures is a further unresolved hurdle toward the recyclability of these elements. There is a need for broadening the spectrum of polymeric foams. In this context, the foamability of polybutene‐1 (PB‐1) is studied through extrusion foaming experiments. From the application side, foaming PB‐1 would allow the manufacturing of district heating pre‐insulated pipes out of one single material, bringing circular product design to the energy sector. From the scientific side, there is a knowledge gap in the foaming of polymers in the rubbery state at room temperature, such as PB‐1, due to difficulties in the cell stabilization step. This supports the need for research in the foaming of this polymer. In this study, four commercial grades of PB‐1 were evaluated, covering different chain structures, molecular weights, and crystallinity degrees. Very different foaming behaviors were found. Dimensionally stable foams were achieved with the two homopolymers tested, demonstrating the foamability of this polymer.
Have urinary function outcomes after radical prostatectomy improved over the past decade?
Authors: Clements Matthew B. , Gmelich Caroline C. , Vertosick Emily A. , Hu Jim C. , Sandhu Jaspreet S. , Scardino Peter T. , Eastham James A. , Laudone Vincent P. , Touijer Karim A. , Coleman Jonathan A. , Vickers Andrew J. , Ehdaie Behfar 
Published: November 2021

BackgroundChanges in surgical technique and postoperative care that target improvements in functional outcomes are widespread in the literature. Radical prostatectomy (RP) is one such procedure that has seen multiple advances over the past decade. The objective of this study was to leverage RP as an index case to determine whether practice changes over time produced observable improvements in patient‐reported outcomes.MethodsThis study analyzed patients undergoing RP by experienced surgeons at a tertiary care center with prospectively maintained patient‐reported outcome data from 2008 to 2019. Four patient‐reported urinary function outcomes at 6 and 12 months after RP were defined with a validated instrument: good urinary function (domain score ≥ 17), no incontinence (0 pads per day), social continence (≤1 pad per day), and severe incontinence (≥3 pads per day). Multivariable logistic regressions evaluated changes in outcomes based on the surgical date.ResultsAmong 3945 patients meeting the inclusion criteria, excellent urinary outcomes were reported throughout the decade but without consistent observable improvements over time. Specifically, there were no improvements in good urinary function at 12 months (P = .087) based on the surgical date, and there were countervailing effects on no incontinence (worsening; P = .005) versus severe incontinence (improving; P = .003). Neither approach (open, laparoscopic, or robotic), nor nerve sparing, nor membranous urethral length mediated changes in outcomes.ConclusionsIn a decade with multiple advances in surgical and postoperative care, there was evidence of improvements in severe incontinence, but no measurable improvements across 3 other urinary outcomes. Although worsening disease factors could contribute to the stable observed outcomes, a more systematic approach to evaluating techniques and implementing patient selection and postoperative care advances is needed.Lay Summary

Although there have been advances in radical prostatectomy over the past decade, consistent observable improvements in postoperative incontinence were not reported by patients.

To improve urinary function outcomes beyond the current high standard, the approach to studying innovations in surgical technique needs to be changed, and further development of other aspects of prostatectomy care is needed.
Cutaneous adverse events in 155 patients with metastatic melanoma consecutively treated with anti‐CTLA4 and anti‐PD1 combination immunotherapy: Incidence, management, and clinical benefit
Authors: Patel Anisha B. , Farooq Sahira , Welborn Macartney , Amaria Rodabe N. , Chon Susan Y. , Diab Adi , Glitza Oliva Isabella C. , Huen Auris O. , Li Shirley Q. , Nelson Kelly C. , Pacha Omar , Patel Sapna P. , Rapini Ronald P. , Tawbi Hussein A. , Wong Michael K. , McQuade Jennifer , Davies Michael A. , Haydu Lauren E. 
Published: November 2021

BackgroundIn response to the increased use of combination checkpoint inhibitors (CPIs) and the resulting increased cutaneous adverse events (CAEs), this study reviewed patients with melanoma treated with combination CPIs to characterize CAE features and their clinical impact, correlation to adverse events in other organs, and correlation to tumor response.MethodsPatients from the authors' institutional database who received at least 1 dose of ipilimumab in combination with either nivolumab or pembrolizumab between January 1, 2012, and December 31, 2017, for stage IV or unresectable stage III melanoma were identified. The time to next treatment (TTNT) was calculated from the start of CPI therapy to the start of the next treatment or death, and the development of CAEs was tested in a time‐dependent Cox regression to identify associations with TTNT.ResultsEighty‐one patients (52.3%) experienced a total of 92 CAEs, including eczematous dermatitis (25.0%), morbilliform eruption (22.8%), vitiligo (12.0%), and pruritus without rash (8.7%). The median times to the onset and resolution of CAEs were 21 days (range, 0‐341 days) and 50 days (range, 1‐352 days), respectively. Most CAEs resolved after patients entered the CPI maintenance phase and treatment with oral antihistamines with or without topical steroids. CPI discontinuation occurred in 4 patients (2.6%) because of CAEs, in 49 (31.6%) because of other immune‐related adverse events, and in 20 (12.9%) because of melanoma progression or death. For patients definitively treated with CPIs (n = 134; 86.5%), TTNT was significantly longer with CAEs than without CAEs (hazard ratio, 0.567; 95% CI, 0.331‐0.972; P = .039).ConclusionsCAEs were mostly reversible and rarely required therapy discontinuation. The development of CAEs was associated with a longer TTNT, and this suggested a possible clinical benefit.
Growth and remodeling in the pulmonary autograft: Computational evaluation using kinematic growth models and constrained mixture theory
Authors: Vastmans Julie , Maes Lauranne , Peirlinck Mathias , Vanderveken Emma , Rega Filip , Kuhl Ellen , Famaey Nele 
Published: November 2021

AbstractComputational investigations of how soft tissues grow and remodel are gaining more and more interest and several growth and remodeling theories have been developed. Roughly, two main groups of theories for soft tissues can be distinguished: kinematic‐based growth theory and theories based on constrained mixture theory. Our goal was to apply these two theories on the same experimental data. Within the experiment, a pulmonary artery was exposed to systemic conditions. The change in diameter was followed‐up over time. A mechanical and microstructural analysis of native pulmonary artery and pulmonary autograft was conducted. Whereas the kinematic‐based growth theory is able to accurately capture the growth of the tissue, it does not account for the mechanobiological processes causing this growth. The constrained mixture theory takes into account the mechanobiological processes including removal, deposition and adaptation of all structural constituents, allowing us to simulate a changing microstructure and mechanical behavior.
Review of the Development of First‐Generation Redox Flow Batteries: Iron‐Chromium System
Authors: Sun Chuanyu , Zhang Huan 
Published: November 2021

AbstractThe iron‐chromium redox flow battery (ICRFB) is considered the first true RFB and utilizes low‐cost, abundant iron and chromium chlorides as redox‐active materials, making it one of the most cost‐effective energy storage systems. ICRFBs were pioneered and studied extensively by NASA and Mitsui in Japan in the 1970–1980s, and extensive studies on ICRFBs have been carried out over the past few decades. In addition, ICRFB is considered to be one of the most promising directions for cost‐effective and large‐scale energy storage applications, as its cost can theoretically be lower than that of zinc‐bromine and all‐vanadium RFBs, giving it the potential for large‐scale promotion. With the resolution of problems such as hydrogen evolution and electrolyte intermixing, the ICRFB technology is moving out of the laboratory and striving for greater power and more stable industrialization requirements. This Review summarizes the history, development, and research status of key components (carbon‐based electrode, electrolyte, and membranes) in the ICRFB system, aiming to give a brief guide to researchers who are involved in the related subject.
Inflammation neuroscience: neuro‐immune crosstalk and interfaces
Authors: Tarnawski Laura , Olofsson Peder S 
Published: November 2021

AbstractInflammation is a key process in antimicrobial defence and tissue repair, and failure to properly regulate inflammation can result in tissue damage and death. Neural circuits play important roles throughout the course of an inflammatory response, and the neurophysiological and molecular mechanisms are only partly understood. Here, we review key evidence for the neural regulation of inflammation and discuss emerging technologies to further map and harness this neurophysiology, a cornerstone in the rapidly evolving field of inflammation neuroscience.