bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Experience Over 15 Years with the B-Lynch Compression Suture Technique in the Management of Postpartum Hemorrhage
Authors: Nagahama Gilberto , Korkes Henri Augusto , Sass Nelson 
Published: October 2021

Abstract
Objective To describe the clinical experience with the B-Lynch technique in the management of postpartum hemorrhage as well as the factors related to the indication of the technique and to present the success rates of the application of the B-Lynch technique.
Methods Observational, retrospective, cross-sectional, and analytical study. Patient data was obtained through the study of medical records. The study population comprised of patients who underwent hemostatic suture using the B-Lynch technique, including 104 patients within the period from January 1, 2005, to December 31, 2019.
Results Of the total of 104 patients, 82.7% did not present any complications. Blood transfusion and intensive care unit admission were the most prevalent complications, with 13.5% and 15.4%, respectively. Only 1% of the patients had puerperal and surgical site infections. The factors most related to the application of the technique were the presence of previous cesarean section (30.8%), use of oxytocin (16.3%), and preeclampsia (11.6%). Puerperal hysterectomy was performed in 4.8% of the patients due to failure of the method.
Conclusion The clinical experience with the B-Lynch technique was satisfactory since it presented few complications, with excellent results in hemorrhagic control. Previous cesarean section, the use of oxytocin, and preeclampsia stood out as factors related to the indication of the application of the technique, and the success rate in controlling postpartum hemorrhage was 95.2%.
Pathways of IFN-alpha Activation in Patients with Cervical Intraepithelial Neoplasia (CIN)
Authors: Tirone Nelson Ranieri , Campos Carolina Guissoni , Ferreira Kézia Jesus Aguiar , Stark Léticia Montes , Vieira Jéssica Ferreira , Murta Eddie Fernando Cândido , Michelin Márcia Antoniazi 
Published: October 2021

Abstract
Objective The aim of the present study was to compare the local and systemic expression of the factors linked to the interferon alpha (IFN-α) activation pathway in different degrees of cervical intraepithelial neoplasia (CIN) and cervical cancer.
Methods A total of 128 patients with CIN I, CIN II, CIN III and cervical cancer was evaluated. The real-time polymerase chain reaction (RT-PCR) technique was used to evaluate the gene expression of IFNR1, IFNR2, IFN-α, oligoadenylate synthase (2'5′OAS), cytokine signal suppressor 1 (SOCS) 1, SOCS3, signal transducer and transcription activator 1 (STAT1), and IRF9 from 128 biopsies. A total of 46 out of 128 samples were evaluated by flow cytometry for IFNAR1, IFNAR2, STAT1, IRF7 and IFN-α in peripheral blood cells.
Results Patients with CIN II and III (63 samples) had a low local expression of IFNR1, but not IFNR2. Patients with some degree of injury showed high expression of SOCS1 and SOCS3. Systemically, patients with CIN II and III (20 samples) had a significant increase in IFNR1, IFNR2, STAT1, IRF7, and IFN-α in helper, cytotoxic T lymphocytes, and in monocytes.
Conclusion Patients with high-grade lesions have increased systemic expression of IFN-α and its activation pathways in helper and cytotoxic T lymphocytes, as well as in monocytes due to an exacerbation of the immune response in these patients. This phenomenon is not accompanied by resolution of the lesion due to a defect in the IFN-α activation pathway that revealed by low local IFNAR1 expression and high local expression of SOCS1 and SOCS3.
Complete Androgen Insensitivity Syndrome: A Rare Case of Prenatal Diagnosis
Authors: Coelho Maria Liz , Soares Elisa , Freixo Marília , Brandão Pedro , Marinho Carla , Rocha Juliana , Rodrigues Graça 
Published: October 2021

AbstractWith the widespread uptake of noninvasive prenatal testing (NIPT), a larger cohort of women has access to fetal chromosomal sex, which increases the potential to identify prenatal sex discordance. The prenatal diagnosis of androgen insensitivity syndrome (AIS) is an incidental and rare finding. We wish to present the diagnosis of a prenatal index case after NIPT of cell-free fetal DNA and mismatch between fetal sex and ultrasound phenotype. In this particular case, the molecular analysis of the androgen receptor (AR) gene showed the presence of a pathogenic mutation, not previously reported, consistent with complete androgen insensitivity syndrome. Carrier testing for the mother revealed the presence of the same variant, confirming maternal hemizygous inheritance. Identification of the molecular basis of these genetic conditions enables the preimplantation or prenatal diagnosis in future pregnancies.
A New Perspective of COVID-19 Infection: An Epigenetics Point of View
Authors: Ozturkler Ziya , Kalkan Rasime 
Published: October 2021

AbstractCoronavirus disease 2019 (COVID-2019) started in Wuhan, China, in December 2019. Angiotensin-converting enzyme 2 (ACE2) receptor was one of the most important genes related to the entrance of the virus to the host. Until now, several variations have been identified in ACE2 and related transmembrane protease serine 2. Epigenetic modifications not only play an important role during the maintenance of genome and cellular homoeostasis but also for the etiopathophysiology of the virus infection. Studies showed methylation of ACE2 was changed to depend on host and age of the host during the viral infection.In this study, we provided an epigenetics point of view to the coronavirus infection. We highlight the importance of epigenetic modifications during viral replication and infection and their interaction with COVID-19 susceptibility and host viral response.
A three-dimensional reconstruction method for the inner surface of a deep hole using a rotating mechanism
Authors: Pan Shuo , Shao Xinjie , Wang Huaiguang , Song Bin 
Published: October 2021

An inner surface 3D reconstruction device structure is proposed in this paper to reconstruct the complex curved inner surface of a deep hole. First, the optical paths of the camera and the structured light transmitter are converged on the deep hole inner surface through plane mirrors to form a multi-line structured light projection system (MSLPS). The parameters of the MSLPS are then calibrated before the measurement. Second, the MSLPS rotates during the measurement process to obtain the point cloud collections of the inner surface and the rotation angles at different measurement positions are recorded. The point clouds contain the 3D surface information of the measured areas. Finally, the entire surface shape is reconstructed by the proposed reconstruction algorithm, and the feature parameters of the deep hole inner surface can be calculated by the reconstructed point cloud. The development process of the system was demonstrated in the experiment. The proposed system is validated through the reconstruction experiment of different areas in a deep hole.
Virtual screening of norbornadiene-based molecular solar thermal energy storage systems using a genetic algorithm
Authors: Ree Nicolai , Koerstz Mads , Mikkelsen Kurt V. , Jensen Jan H. 
Published: October 2021

We present a computational methodology for the screening of a chemical space of 1025 substituted norbornadiene molecules for promising kinetically stable molecular solar thermal (MOST) energy storage systems with high energy densities that absorb in the visible part of the solar spectrum. We use semiempirical tight-binding methods to construct a dataset of nearly 34 000 molecules and train graph convolutional networks to predict energy densities, kinetic stability, and absorption spectra and then use the models together with a genetic algorithm to search the chemical space for promising MOST energy storage systems. We identify 15 kinetically stable molecules, five of which have energy densities greater than 0.45 MJ/kg, and the main conclusion of this study is that the largest energy density that can be obtained for a single norbornadiene moiety with the substituents considered here, while maintaining a long half-life and absorption in the visible spectrum, is around 0.55 MJ/kg.
Initial effect of shifting from traditional to no-tillage on runoff retention and sediment reduction under rainfall simulation
Authors: Salem Haytham Mohamed , Ali Ali Mohamed , Wu Weicheng , Tu Qihong 
Published: October 2021

Context Low precipitation and soil erosion are critical threats to sustainable agricultural development in the north-western coastal zone of Egypt. Conservation tillage may offer a good opportunity to mitigate these threats; however, switching from traditional tillage to conservation tillage causes initial challenges such as soil compaction and erosion. Aims This study was designed in order to assess the effects of various tillage practices on soil bulk density, volumetric water content, runoff rate, runoff initiation time, soil loss, sediment yield rate and wheat (Triticum aestivum L.) yield in a cultivated basin area. Furthermore, to investigate the efficacy of various rainfall intensities in generating runoff in a micro-catchment area. Methods Under rainfall simulation, five rainfall intensities (14, 21, 30, 36, and 45 mm h−1) and three tillage practices (contour tillage, CT; traditional tillage, TT; and no tillage, NT) were investigated. Key results Under various rainfall intensities, the CT treatment significantly reduced surface runoff compared with the TT and NT treatments. For the 30 mm h−1 rainfall intensity, the CT treatment decreased sediment yield rate by 58.7% and 49.4% compared with NT and TT treatments, respectively. Furthermore, the CT treatment significantly increased precipitation use efficiency by 11.8% and 19.9% compared with TT and NT treatments, respectively. Additionally, the CT increased grain yield by 12.3% more than TT and 21% more than NT. Conclusions and implications Consequently, it is preferable to encourage farmers to use CT practices when transitioning from traditional tillage to conservation tillage. Moreover, soil compaction and smoothing may contribute to enhance the generated runoff on the micro-catchment area.
Differential effects of PD-1 and CTLA-4 blockade on the melanoma-reactive CD8 T cell response
Authors: Gangaev Anastasia , Rozeman Elisa A. , Rohaan Maartje W. , Isaeva Olga I. , Philips Daisy , Patiwael Sanne , van den Berg Joost H. , Ribas Antoni , Schadendorf Dirk , Schilling Bastian , Schumacher Ton N. , Blank Christian U. , Haanen John B. A. G. , Kvistborg Pia 
Published: October 2021

Significance
Despite the success of checkpoint-targeting therapies, many melanoma patients do not respond or acquire resistance after initial responsiveness. A better understanding about the mechanism by which these therapies enhance immune-mediated tumor control is key to providing the rationale for better treatment strategies. In this study, we show that PD-1 blockade does not modulate the breadth or the magnitude of the circulating tumor-reactive CD8 T cell response. In contrast and in concordance with our previous study, CTLA-4 blockade leads to a broadening of the circulating melanoma-reactive CD8 T cell response. Together, these findings show differential mechanisms of action of CTLA-4 and PD-1 blockade and support the synergy of the combination treatment seen in the clinic.
Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson’s disease
Authors: Fougère Maxime , van der Zouwen Cornelis Immanuel , Boutin Joël , Neszvecsko Kloé , Sarret Philippe , Ryczko Dimitri 
Published: October 2021

Significance
In Parkinson’s disease, alleviating locomotor deficits is a challenge. Clinicians are exploring the deep brain stimulation of the mesencephalic locomotor region, a brainstem region controlling locomotion, but results are mixed. However, the best target in this region in Parkinson’s disease remains unknown. Indeed, this region, which comprises the pedunculopontine and cuneiform nuclei, contains different cell types with opposing effects on locomotor output. Here, using mice in which midbrain dopaminergic cells were damaged by a neurotoxin, we demonstrate that optogenetic activation of glutamatergic neurons in the cuneiform nucleus increases locomotion, controls speed, and evokes limb movements similar to those observed during spontaneous locomotion in intact animals. Our study identifies a potentially clinically relevant target to improve locomotor function in Parkinson’s disease.
The translatome of neuronal cell bodies, dendrites, and axons
Authors: Glock Caspar , Biever Anne , Tushev Georgi , Nassim-Assir Belquis , Kao Allison , Bartnik Ina , tom Dieck Susanne , Schuman Erin M. 
Published: October 2021

Significance
Proteins are the key drivers of neuronal synaptic function. The regulation of gene expression is important for the formation and modification of synapses throughout the lifespan. The complexity of dendrites and axons imposes unique challenges for protein supply at remote locations. The discovery of messenger RNAs (mRNAs) and ribosomes near synapses has shown that local protein synthesis represents an important solution to this challenge. Here we used RNA sequencing and ribosome sequencing to determine directly the population of mRNAs that is present and in the process of translation in neuronal cell bodies, dendrites, and axons. Thousands of transcripts were differentially translated between the cell body and synaptic regions with over 800 mRNAs exhibiting more translation in the dendritic–axonal compartment.
Exploring the self-tuning of the cosmological constant from Planck mass variation
Authors: Blanco Daniel Sobral , Lombriser Lucas 
Published: October 2021

Abstract
Recently, the variation of the Planck mass in the general relativistic Einstein–Hilbert action was proposed as a self-tuning mechanism of the cosmological constant, preventing standard model vacuum energy from freely gravitating and enabling an estimation of the magnitude of its observed value. We explore here new aspects of this proposal. We first develop an equivalent Einstein-frame formalism to the current Jordan-frame formulation of the mechanism and use this to highlight similarities and differences of self-tuning to the sequestering mechanism. We then show how with an extension of the local self-tuning action by a coupled Gauss–Bonnet term and a companion four-form field strength, graviton loops can be prevented from incapacitating the degravitation of the standard model vacuum energy. For certain cases, we furthermore find that this extension can be recast as a Horndeski scalar–tensor theory and be embedded in the conventional local self-tuning formalism. We then explore the possibility of a unification of inflation with self-tuning. The resulting equations can alternatively be used to motivate a multiverse interpretation. In this context, we revisit the coincidence problem and provide an estimation for the probability of the emergence of intelligent life in our Universe as a function of cosmic age, inferred from star and terrestrial planet formation processes. We conclude that we live at a very typical epoch, where we should expect the energy densities of the cosmological constant and matter to be of comparable size. For a dimensionless quantity to compare the emergence of life throughout the cosmic history of different universes in an anthropic analysis of the multiverse, we choose the order of magnitude difference of the evolving horizon size of a Universe to the size of its proton as the basic building block of atoms, molecules, and eventually life. For our Universe we find this number to form peak at approximately 42. We leave the question of whether the same number is frequently assumed for the emergence of life across other universes or singles out a special case to future exploration.
Enhanced broadband monopole emission and acoustic energy harvesting via a dual anisotropic metamaterial
Authors: Lei Yunzhong , Wu Jiu Hui , Huang Zhen , Yang Shaokun 
Published: October 2021

Abstract
Broadband sound energy enhancement is essential in practical scenarios, such as acoustic positioning and acoustic communication. In this paper, a dual anisotropic metamaterial composed of an inner Mie resonator and an outer acoustic grating is proposed, aiming to achieve enhanced broadband monopole emission and acoustic energy harvesting (AEH) via the coupling of the first and second monopole resonances. Considering thermo-viscous dissipation, numerical simulations and experimental results demonstrate that the dual anisotropic metamaterial can realize omnidirectional enhanced broadband monopole emission at 795 Hz–1511 Hz, the maximum sound pressure level (SPL) gain is 16.4 dB and the SPL gain fluctuation is 3 dB. Furthermore, simulation results reveal that the broadband AEH can be achieved by the dual anisotropic metamaterial, the fluctuation of the SPL gain at 794 Hz–1537 Hz is 3 dB and the maximum is 14.7 dB. Based on the results, the dual anisotropic metamaterial is expected to show significant potentials in acoustic positioning and acoustic communication.
Dye-synthesized N, S co-doped carbon via plasma engineering as metal-free oxygen reduction reaction electrocatalysts
Authors: Son Hyunjee , Kim Seonghee , Lee Jin Hong , Li Oi Lun 
Published: October 2021

Abstract
Emerging metal-free heterogeneous element-doped carbon-based catalysts have shown advantages of high catalytic efficiency and low cost, and are regarded as a promising alternative to metal catalysts in alkaline-based fuel cells and metal–air batteries. Methylene blue, commonly used to stain specimens, has been causing serious marine pollution and should be considered for eco-friendly recycling. In this study, methylene blue was chosen as an additive and precursor for N- and S-doped carbon nanoparticles and was dissolved in quinoline (C9H7N) to synthesize N, S co-doped carbon electrocatalysts via plasma engineering. Based on the electrochemical analysis conducted using a rotating ring disk electrode system, compared to the carbon catalyst synthesized from pure quinoline, the oxygen reduction reaction (ORR) performance was enhanced by increasing the amount of methylene blue (E
onset = 0.78 V (vs RHE) at 100% quinoline, 0.79 V (vs RHE) at 1 mM MBQ-G, 0.84 V (vs RHE) at 2 mM MBQ-G, and 0.86 V (vs RHE) at 3 mM MBQ-G). From the electrochemical results, the onset potential (E
onset), half-wave potential (E
1/2), and Tafel slope of 3 mM MBQ-G showed the best performance among all the carbon-based catalysts. In addition, the durability properties of 3 mM methylene blue (declined 30 mV after 6000 cycles) is superior to that of the benchmark ORR catalysts of 20 wt.% Pt/C (declined 60 mV after 6000 cycles). Through this study, we have successfully shown the possibility to effectively recycle methylene blue, which often causes marine and water pollution in the dyeing industry, as a useful precursor in carbon-based catalytic materials.
A modified hybrid chemical vapor deposition method for the fabrication of efficient CsPbBr3 perovskite solar cells
Authors: Ullah Saad , Liu Linlin , Yang Shi-E , Liu Ping , Guo Haizhong , Chen Yongsheng 
Published: October 2021

Abstract
Due to its outstanding stability, all-inorganic cesium lead bromide (CsPbBr3) perovskite is gaining increasing attention as a functional material in photovoltaics and other optoelectronic applications. However, the preparation of high-quality CsPbBr3 films via solution processing remains a significant challenge due to the cesium precursor’s low solubility in common solvents. As a result, developing viable evaporation deposition strategies is critical for increasing the photovoltaic performance of perovskite solar cells (PSCs) based on CsPbBr3. In this paper, a modified hybrid chemical vapor deposition is applied to fabricate CsPbBr3 films, and the effects of reaction temperature and reaction time on the crystallinity, morphology, and photo-electric properties of the films are investigated. By optimizing the reaction conditions, high-quality CsPbBr3 films with good crystallinity and uniformity are successfully obtained. Based on these films, CsPbBr3 PSCs with a device configuration of fluorine-doped tin oxide/compact-TiO2/CsPbBr3/carbon attained impressive power conversion efficiency of 4.41% with an ultra-high open-circuit voltage (V
OC) of 1.39 V. This demonstration suggests that the modified hybrid chemical vapor deposition strategy enables a promising fabrication route suitable for all-inorganic perovskite thin films in photovoltaic application.
Giant magnetoresistance and topological Hall effect in the EuGa4 antiferromagnet
Authors: Zhang H , Zhu X Y , Xu Y , Gawryluk D J , Xie W , Ju S L , Shi M , Shiroka T , Zhan Q F , Pomjakushina E , Shang T 
Published: October 2021

Abstract
We report on systematic temperature- and magnetic field-dependent studies of the EuGa4 binary compound, which crystallizes in a centrosymmetric tetragonal BaAl4-type structure with space group I4/mmm. The electronic properties of EuGa4 single crystals, with an antiferromagnetic (AFM) transition at T
N ∼ 16.4 K, were characterized via electrical resistivity and magnetization measurements. A giant nonsaturating magnetoresistance was observed at low temperatures, reaching

∼
7
×
1

0

4

% at 2 K in a magnetic field of 9 T. In the AFM state, EuGa4 undergoes a series of metamagnetic transitions in an applied magnetic field, clearly manifested in its field-dependent electrical resistivity. Below T
N, in the ∼4–7 T field range, we observe also a clear hump-like anomaly in the Hall resistivity which is part of the anomalous Hall resistivity. We attribute such a hump-like feature to the topological Hall effect, usually occurring in noncentrosymmetric materials known to host topological spin textures (as e.g., magnetic skyrmions). Therefore, the family of materials with a tetragonal BaAl4-type structure, to which EuGa4 and EuAl4 belong, seems to comprise suitable candidates on which one can study the interplay among correlated-electron phenomena (such as charge-density wave or exotic magnetism) with topological spin textures and topologically nontrivial bands.
Negative electron affinity opens quantum well in MgO layers on Ag(100)
Authors: Helmreich Rebecca , Classen Andrej , Fauster Thomas 
Published: October 2021

Abstract
Epitaxial MgO films on Ag(100) were studied by photoelectron spectroscopy. From the low-energy part of the spectra we obtain a negative electron affinity of about −0.9 eV. Even though electrons in the lowest conduction band are not confined by a potential barrier at the surface, quantum-well resonances are observed. The dispersion of the conduction band is determined in good agreement with theoretical calculations. Aspects of observing image-potential states predicted by theory on MgO films are discussed.