bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics Analysis of a Prognostic miRNA Signature and Potential Key Genes in Pancreatic Cancer
Authors: Chen Shuoling , Gao Chang , Yu Tianyang , Qu Yueyang , Xiao Gary Guishan , Huang Zunnan 
Published: May 2021

BackgroundIn this study, miRNAs and their critical target genes related to the prognosis of pancreatic cancer were screened based on bioinformatics analysis to provide targets for the prognosis and treatment of pancreatic cancer.MethodsR software was used to screen differentially expressed miRNAs (DEMs) and genes (DEGs) downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, respectively. A miRNA Cox proportional hazards regression model was constructed based on the miRNAs, and a miRNA prognostic model was generated. The target genes of the prognostic miRNAs were predicted using TargetScan and miRDB and then intersected with the DEGs to obtain common genes. The functions of the common genes were subjected to Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses. A protein-protein interaction (PPI) network of the common genes was constructed with the STRING database and visualized with Cytoscape software. Key genes were also screened with the MCODE and cytoHubba plug-ins of Cytoscape. Finally, a prognostic model formed by the key gene was also established to help evaluate the reliability of this screening process.ResultsA prognostic model containing four downregulated miRNAs (hsa-mir-424, hsa-mir-3613, hsa-mir-4772 and hsa-mir-126) related to the prognosis of pancreatic cancer was constructed. A total of 118 common genes were enriched in two KEGG pathways and 33 GO functional annotations, including extracellular matrix (ECM)-receptor interaction and cell adhesion. Nine key genes related to pancreatic cancer were also obtained: MMP14, ITGA2, THBS2, COL1A1, COL3A1, COL11A1, COL6A3, COL12A1 and COL5A2. The prognostic model formed by nine key genes also possessed good prognostic ability.ConclusionsThe prognostic model consisting of four miRNAs can reliably predict the prognosis of patients with pancreatic cancer. In addition, the screened nine key genes, which can also form a reliable prognostic model, are significantly related to the occurrence and development of pancreatic cancer. Among them, one novel miRNA (hsa-mir-4772) and two novel genes (COL12A1 and COL5A2) associated with pancreatic cancer have great potential to be used as prognostic factors and therapeutic targets for this tumor.
Immune-Related Gene SERPINE1 Is a Novel Biomarker for Diffuse Lower-Grade Gliomas via Large-Scale Analysis
Authors: Huang Xiaoming , Zhang Fenglin , He Dong , Ji Xiaoshuai , Gao Jiajia , Liu Wenqing , Wang Yunda , Liu Qian , Xin Tao 
Published: May 2021

BackgroundGlioma is one of the highly fatal primary tumors in the central nervous system. As a major component of tumor microenvironment (TME), immune cell has been proved to play a critical role in the progression and prognosis of the diffuse lower-grade gliomas (LGGs). This study aims to screen the key immune-related factors of LGGs by investigating the TCGA database.MethodsThe RNA-sequencing data of 508 LGG patients were downloaded in the TCGA database. ESTIMATE algorithm was utilized to calculate the stromal, immune, and ESTIMATE scores, based on which, the differentially expressed genes (DEGs) were analyzed by using “limma” package. Cox regression analysis and the cytoHubba plugin of Cytoscape software were subsequently applied to screen the survival-related genes and hub genes, the intersection of which led to the identification of SERPINE1 that played key roles in the LGGs. The expression patterns, clinical features, and regulatory mechanisms of SERPINE1 in the LGGs were further analyzed by data mining of the TCGA database. What’s more, the above analyses of SERPINE1 were further validated in the LGG cohort from the CGGA database.ResultWe found that stromal and immune cell infiltrations were strongly related to the prognosis and malignancy of the LGGs. A total of 54 survival-related genes and 46 hub genes were screened out in the DEGs, within which SERPINE1 was identified to be significantly overexpressed in the LGG samples compared with the normal tissues. Moreover, the upregulation of SERPINE1 was more pronounced in the gliomas of WHO grade III and IDH wild type, and its expression was correlated with poor prognosis in the LGG patients. The independent prognostic value of SERPINE1 in the LGG patients was also confirmed by Cox regression analysis. In terms of the functions of SERPINE1, the results of enrichment analysis indicated that SERPINE1 was mainly enriched in the immune‐related biological processes and signaling pathways. Furthermore, it was closely associated with infiltrations of immune cells in the LGG microenvironment and acted synergistically with PD1, PD-L1, PD-L2.ConclusionThese findings proved that SERPINE1 could serve as a prognostic biomarker and potential immunotherapy target of LGGs.
Sunburn, Sun Safety and Indoor Tanning Among Schoolchildren in Ireland
Authors: Költő András , Rodriguez Lauren , McAvoy Helen , Nic Gabhainn Saoirse 
Published: May 2021

Objectives: We present patterns of sunburn, sun safety behaviors and indoor tanning bed use in a nationally representative sample of schoolchildren aged 10–17. These behaviors were explored across gender, age, and social class groups.Methods: Within the Health Behaviour in School-aged Children (HBSC) Ireland study, 10,271 young people (aged 13.54 ± 1.92, percentage girls 53.3%) reported frequency of sun safety behaviors, sunburn, and frequency and circumstances of indoor tanning bed use.Results: Children frequently experienced sunburn (90% lifetime, 74% last year), and 3% reported never using any sun protection. Applying sunscreen and wearing sunglasses were the most commonly used sun safety measures; other ways of sun protection were less popular. Indoor tanning bed use was reported by around 5%, and a large proportion of users were not advised of any indoor tanning safety measures. Sun safety behaviors varied by age and gender, with some socio-economic differences in tanning bed use. An association was found between frequency of family holidays abroad and sunburn.Conclusion: Targeted interventions are needed to increase sun safety behaviors and eliminate tanning bed use among children in Ireland.
Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico and Biochemical Approach
Authors: Saddique Furqan Ahmad , Aslam Sana , Ahmad Matloob , Ashfaq Usman Ali , Muddassar Muhammad , Sultan Sadia , Taj Saman , Hussain Muzammil , Sung Lee Dae , Zaki Magdi E. A. 
Published: May 2021

Diabetes mellitus (DM) is a chronic disorder and has affected a large number of people worldwide. Insufficient insulin production causes an increase in blood glucose level that results in DM. To lower the blood glucose level, various drugs are employed that block the activity of the α-glucosidase enzyme, which is considered responsible for the breakdown of polysaccharides into monosaccharides leading to an increase in the intestinal blood glucose level. We have synthesized novel 2-(3-(benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides and have screened them for their in silico and in vitro α-glucosidase inhibition activity. The derivatives 11c, 12a, 12d, 12e, and 12g emerged as potent inhibitors of the α-glucosidase enzyme. These compounds exhibited good docking scores and excellent binding interactions with the selected residues (Asp203, Asp542, Asp327, His600, Arg526) during in silico screening. Similarly, these compounds also showed good in vitro α-glucosidase inhibitions with IC50 values of 30.65, 18.25, 20.76, 35.14, and 24.24 μM, respectively, which were better than the standard drug, acarbose (IC50 = 58.8 μM). Furthermore, a good agreement was observed between in silico and in vitro modes of study.
Evaluation of cone beam computed tomography imaging in placed dental implants: comparison between multiplanar reconstruction and parasagittal images / Avaliação de imagens de tomografia computadorizada de feixe cônico em implantes instalados: comparação entre reconstrução multiplanar e imagens parassagitais
Authors: Chagas Mariana Murai , Silva Maria Alves Garcia , Cavalcanti Marcelo Gusmão Paraiso 
Published: May 2021

This study aimed to compare multiplanar reconstruction (MPR) to parasagittal images of cone-beam computed tomography (CBCT) for localizing placed dental implants concerning adjacent anatomical structures (nasal fossa floor, maxillary sinus, inferior alveolar canal and nasopalatine canal).The CBCT exams of 164 placed implants were analyzed. All tomographic images were imported to Imaging Studio software to create parasagittal image templates. The images were randomized and analyzed by two oral and maxillofacial radiologists who classified whether or not there was perforation of the anatomical structure in question.According to Kappa coefficient of agreement, the results including, all anatomical structures for inter-observer assessment was 0.81 and for intra-observer assessment, 0.79 for observer one and 0.89 for observer two. For each anatomical structure, the agreement ranged from 'substantial' to 'almost perfect' (nasal fossa floor 0.72, nasopalatine canal 0.92, maxillary sinus 0.81, and inferior alveolar canal 0.81). Based on our findings, there was substantial to almost perfect agreement when comparing MPR and parasagittal images of CBCT regarding of implant position relationship with anatomical structures. Since both modalities did not differ in implant position, and the MPR represents the complete and original volume that enables analysis in three dimensions, they can be the first-choice imaging modality to analyze placed dental implants.
Pemilihan Kepala Daerah Lampung Selatan: Telaah Pengaruh Pendidikan Politik, Komunikasi Politik dan Sosial Ekonomi terhadap Partisipasi Politik
Authors: Tamara Guntur Ardyan , Darmastuti Ari , Warganegara Arizka 
Published: May 2021

The decreasing of public’s politics participation phenomenon on Regional Head Election of Lampung Selatan District was about 72 % on 2010 and 65% on 2015. Based on average counts of Regional Head Election 2015, Kalianda Sub District was the lowest. This is a quantitative study with explanatory method. The 250 samples were determined by using proportional area random sampling. The result shows that the public’s political education was categorized low. Meanwhile, Kalianda Sub District has a high number for public’s politics communication or the other words publics have a good political communication to the candidates. The public’s economic status in Kalianda Sub District is categorized as high enough, on the other words that people already have a good living for both in economy and social. Based on statistical test result, Political Education has an impact to the politics participation partially by t count > t table as 3,630 > 1,977, with 43,3% amount of impact. The political Communication has an impact to politics participation about 4,260 > 1,977 on t count > t table, with 62,2% impact. Social Economics status has an impact by t count > t table about 3,315 > 1,977, with 48% amount of impact. Whereas, political education, political communication, and Social Economics status have an impact with the review Fcount > Ftable (68,957 > 2,710 ) and 51,2% amount of impact.
Evaluasi Kebijakan Fasilitasi Pendanaan APK oleh KPU pada Pilgub Lampung 2018
Authors: Sari Ade Lidya , Hertanto Hertanto , Maryanah Tabah 
Published: May 2021

The facilitation policy of the Campaign Props (APK) for the Lampung Governor Election (Pilgub) in 2018 was the form from the state through the General Election Commission (KPU) for giving the value of equality and justice to the candidate pairs (paslon) in campaigning. The study aims to find out how the APK facilitation mechanism by KPU of Lampung Province in Pilgub Lampung 2018. And what is the impact of the policy evaluation to the APK facilitation in Pilgub Lampung 2018. The type of this research is descriptive qualitative. The results of the study show: 1) That the APK policy mechanism is created that the policy runs well, there is no distortion in the distribution of communication, the number of ASNs that in the quota restrictions, but its implementation has no significant effect, KPU of Lampung Province is able to maintain its integrity, the changes or the additional bureaucratic structure are no needed in the APK policy implementation. 2) The policy evaluation results of the study stated that the APK facilitation policy was not effective and efficient yet because the policy goals were not felt by all the paslon and the costs incurred did not reach the highest effectiveness. The aspects of adequacy and equity were not fulfilled due to inadequate APK quantity. The the public’s responsiveness is neither apathetic nor positive, in the end the policy objectives were not achieved substantively, so the APK facilitation policy in the Pilgub Lampung 2018 did not reach the accuracy aspect. The impact of this policy is paslon printed the APK outside the provisions, the euphoria was less pronounced but on the other side the beauty aesthetic appears.
Southern Protestant Voices during the Irish War of Independence and Civil War: Reports from Church of Ireland Synods
Authors: Walker Brian M. 
Published: May 2021

This chapter records the experiences of southern members of the Church of Ireland, the largest protestant denomination, during the period of the Irish revolution, 1919–23. The main source is one that has been rarely used in the past. It involves the speeches of Church of Ireland bishops at annual local and national diocesan synods during these tumultuous years. As both leaders and observers of their dioceses, the bishops' comments reflected many of the concerns and anxieties of their community. They recorded the violence which forced many members of the church to leave Ireland at this time. They also spoke of efforts to maintain good relations between denominations.
Excerpts from Abdelkébir Khatibi and Jacques Hassoun, Le Même Livre (Paris: Editions de l’Eclat, 1985)
Authors: Harrison Olivia C. 
Published: May 2021

In 1985, the Moroccan writer Abdelkébir Khatibi and the Egyptian Jewish psychoanalyst Jacques Hassoun published an epistolary book, Le même livre (‘The same book’), excerpts of which are translated here for the first time. Playing on the Arabic notion ahl al-kitab, the people of the Book common to Jews, Christians and Muslims, Le même livre centres round the twin figures of the Semite – the Jew and the Arab – as they have been articulated in theological, political and poetic discourses in order to question, and move beyond, the opposition naturalised in the expression ‘Judeo-Arab conflict’. Previewing the dialogue Khatibi would have with another Francophone Jewish exile, Jacques Derrida, in the 1990s, Le même livre is a deconstruction of identity, be it religious, ethnic, cultural or linguistic. Against sameness, Khatibi and Hassoun offer an ‘exercise in alterity’ written in the pages of The Same Book.
First Reactions: The Review Debate and the Initial Response to The New Poetry
Authors: Wootten William 
Published: May 2021

This chapter considers the debate between A. Alvarez and Donald Davie published in the April/May 1962 issue of poetry magazine The Review. The debate aired some of the more significant thoughts and positions that Davie and Alvarez would develop in opposition to one another over the coming years, albeit in ways that are yet to be fully formed. At the same time, Alvarez and Davie agreed far more than one might expect. The debate also cast Alvarez as the practical man who would go beyond the fiddle of poetry, and Davie as the craftsman and aesthete. Yet it is Alvarez who asks far more of poetry. The remainder of the chapter describes how the debate between Davie and Alvarez differs from a more frequently iterated debate between the Movement and its opposition as well as the the high-profile discussions spawned by the debate.
Les versvs avrei chez Virgile, des Bucoliques à l’ Énéide
Authors: Foucher Antoine 
Published: May 2021

En nous appuyant sur une définition stricte du uersus aureus , nous analyserons dans cet article les structures verbales, phoniques et métriques de ce type de vers dans les trois œuvres majeures de Virgile pour y montrer l’influence de Catulle, mais aussi les évolutions en fonction des genres pratiqués par Virgile. Nous nous intéresserons aussi aux emplois du uersus aureus dans les œuvres de Virgile : s’il est vrai qu’il apparaît souvent devant ponctuation forte, plus largement, il contribue à la colométrie virgilienne en s’associant à des structures syntaxiques déterminées, tout comme il est indubitablement associé à des structures ou à des thèmes particuliers, tels que la description.
Two-Dimensional Transesophageal Echocardiography Assessment of the Major Aortic Annulus Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Librera Mariateresa , Carlomagno Guido , Paolillo Stefania , Romano Maurizio , Antonini-Canterin Francesco , D'Alto Michele , De Martino Giuseppe , Briguori Carlo 
Published: May 2021

Background:
Multidetector computed tomography (MDCT) is the gold standard in annulus sizing before transcatheter aortic valve replacement (TAVR). However, MDCT has limited applicability in specific subgroups of patients, such as those with atrial fibrillation and chronic kidney disease. Two-dimensional transesophageal echocardiography (2DTEE) has traditionally been limited to the long-axis measurement of the anteroposterior diameter of the aortic annulus. We describe a new 2DTEE approach for the measurement of the major diameter of the aortic annulus.

Methods:
Seventy-six patients with symptomatic severe aortic valve stenosis and high surgical risk underwent MDCT and 2DTEE before TAVR. A modified five-chamber view was used to measure the major aortic annulus diameter. This was obtained starting from a mid-esophageal four chamber and retracting the TEE probe up until the left ventricular outflow tract and the left and noncoronary aortic cusps were visualized: major aortic annulus diameter was measured as the distance between their insertion points in systole.

Results:
Major aortic annulus diameters measured at 2DTEE showed good correlation with MDCT diameter (r = 0.79; P < 0.001) and perimeter (r = 0.87; P < 0.0001). Using factsheet-derived sizing criteria, 2DTEE alone would have allowed accurate sizing in 75% of patients, with 21% of oversizing predominantly with smaller annuli.

Conclusions:
We describe a new method for 2DTEE measurement of the major aortic annulus diameter; this approach is simple, correlates with MDCT, and allows adequate TAVR sizing in most patients. These findings may help in the assessment of patients with contraindications to or inadequate MDCT images.
Bicuspid Aortic Valve Disease from Infancy to Older Age
Authors: Benini Annachiara , Benfari Giovanni , Pilati Mara , Luciani Giovanni Battista , Ribichini Flavio Luciano , Prioli Maria Antonia 
Published: May 2021

Aim:
Bicuspid aortic valve (BAV) is the most common congenital heart defect, with considerable risk of morbidity and mortality. The purpose of the study was to analyze clinical and echocardiographic presentation of BAV in a large-volume tertiary Italian center and to test their interaction with full age span, sex, and first diagnosis versus second referral.

Methods:
Consecutive patients of all ages diagnosed with BAV at our center from January 1988 to December 2012 were retrospectively included. Exclusion criteria were as follows: associated complex congenital cardiac disease, systemic syndrome, and previous cardiac surgery.

Results:
Eligible patients were 790, divided by age quartiles. Seventy-two percent of patients had any grade BAV dysfunction. Aortic valve stenosis was more frequent in the first (24%) and fourth (24%) quartiles. This corresponds to a double-peak stenosis severity curve, being more severe at a very young age and in the elderly. Aortic valve regurgitation was more prevalent in each quartile than stenosis, with a prevalence of 72% in the second quartile and 77% in the third quartile. This corresponds to a single-peak regurgitation severity curve, being more severe in the fourth and fifth decades of life. Patients with previously diagnosed BAV had more significant valve dysfunction in comparison to patients with first diagnosis of BAV, either stenosis (15% vs. 21%, P = 0.024) or regurgitation (58% vs. 68%, P = 0.006).

Conclusion:
The dominant BAV dysfunction in this large Northern Italian community is regurgitation, with higher severity of disease in the fourth and fifth decades of life.
Can Tei Index Predict High Syntax Score in Patients with Chronic Coronary Syndrome and Normal Left Ventricular Systolic Function?
Authors: Mansour Hazem , Nassar Ahmed Ibrahim , Abdel Rehim Walaa Adel , Roushdy Alaa Mahmoud , Abobakr Mohamed , Zaki Hala Mohamed , Aboubakr El Missiri Ahmed Mohamed 
Published: May 2021

Objective:
Some patients who had chronic coronary syndrome (CCS) and were recognized as low risk, however, developed cardiovascular events, whereas others who were categorized as high risk did not develop any cardiovascular events. Invasive coronary angiography is the gold standard tool for the assessment of coronary artery disease (CAD) severity. The SYNTAX score (SS) was recently recognized as an invasive angiographic-guided scoring system used in risk stratification of patients who have more than one-vessel CAD and undergoing revascularization with percutaneous cardiovascular intervention. It has a good predictive value of adverse cardiovascular events. Exploration for unique noninvasive modalities that may help in a better way for risk stratification of CCS patients by predicting the severity of CAD (as reflected by SS) would be of a paramount value. Tei index is a promising modality for that objective, which is a Doppler-derived time interval index that combines both systolic and diastolic cardiac performance.

Methods:
We examined the relationship between the severity of CAD as assessed by the SS and Tei index in 100 patients with CCS and normal left ventricular systolic function.

Results:
All the studied 100 patients had a normal ejection fraction with mean = 58.92 ± 7.88; the mean value of Tei index was 0.84 ± 0.26. There was a statistically significant positive association between Tei index and SS (P = 0.0001); moreover, there was a correlation between left anterior descending (LAD) affection and Tei index (P = 0.0001).The cutoff point of Tei index to detect SS above 22 was >0.93 (with specificity of 86.5% and sensitivity of 42.4%).

Conclusion:
Tei index significantly correlates with SS and LAD affection. Moreover, it is a cheap, radiation-free, noninvasive technique and may be used as a further risk stratification modality beyond others.