bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Education Framework for Effective Implementation of a Health Information System: Scoping Review
Authors: Jeyakumar Tharshini , McClure Sarah , Lowe Mandy , Hodges Brian , Fur Katharine , Javier-Brozo Mariquita , Tassone Maria , Anderson Melanie , Tripp Tim , Wiljer David 
Published: January 2021

Background
To optimize their use of a new Health Information System (HIS), supporting health care providers require effective HIS education. Failure to provide this education can significantly hinder an organization’s HIS implementation and sustainability efforts.

Objective
The aim of this review is to understand the most effective educational strategies and approaches to enable health care providers to optimally use an HIS.

Methods
Ovid MEDLINE, Ovid Embase, EBSCO Cumulative Index to Nursing and Allied Health Literature, and EBSCO Education Resources Information Center were searched to identify relevant papers. Relevant studies were systematically reviewed and analyzed using a qualitative thematic analysis approach.

Results
Of the 3539 studies screened, 17 were included for data extraction. The literature on the most effective approaches to enable health care providers to optimally use an HIS emphasized the importance of investing in engaging and understanding learners in the clinical context, maximizing the transfer of learning to care, and designing continuous and agile evaluation to meet the emerging demands of the clinical environment.

Conclusions
This review supports the advancement of a new HIS learning framework that organizational leaders and educators can use to guide HIS education design and development. Future research should examine how this framework can be translated into practice.
Epidemioclinical profile and management of post thrombotic syndrome in Antananarivo
Authors: Rajaobelison TSIRIMALALA , Randimbinirina ZAKARIMANANA LUCAS , Rakotorahalahy RNAL , Ravalisoa AML , Rakotoarisoa AJC 
Published: January 2021

Introduction: The post-thrombotic syndrome (PTS) is the most complication of deep vein thrombosis who deserves an early management. The aim of this study was to determine the epidemio-clinical profile and the management of PTS.
Methods: This was a retrospective and descriptive study for a period of 6 years from January 2013 to December 2018, performed at the Cardiovascular Surgery Unit in JRA Teaching Hospital Antananarivo, including all patients who presented post-thrombotic syndrome after an acute episode of deep venous thrombosis.
Results: 106 patients were recorded among 315 patients who presented an episode of DVT (33.65%) and 14110 patients admitted in this period (0.75%). The average age was 46.18 years old. There were 30 males (28.30%) and 76 female (71.69%). The most important risk factors of PTS were previous history of varicose veins (50%), sedentary lifestyle (45.28%), insufficiency of anticoagulant therapy (68.86%) and proximal DVT (47.16%). Delayed of diagnosis were greater than or equal to 2 years after an acute DVT in 86 patients (81.13%). The most clinical signs were edema (56.60%) and varicose veins (54.71%). According the Villalta’s score, PTS were mild in 48 patients (45.28%), moderate in 47 patients (44.33%) and severe in 11 patients (10.37%). Management was lifestyles change (45.28%), compression stockings (100%), anticoagulant therapy (100%) and surgical treatment (65.09%).
Conclusion: The frequency of PTS was 33.65% in our study. PTS reduces quality of life of patients, but it can be avoided if the treatments of DVT are adapted.
Keywords: Deep vein thrombosis, Post-thrombotic syndrome, Epidemiology, Management
A Review on Carissa carandas: Traditional Use, Phytochemical Constituents, and Pharmacological properties
Authors: Bhosale Saurabh Vilas , Shete Rajkumar V. , Adak Vishal  S , Murthy Krishna 
Published: January 2021

Carissa carandas l. (Karaunda) is a widely useful food and medicinal plant of India, Plant-based medicines play an important role in all cultures have been indispensable in maintaining health and combating diseases. Owing to the global trend towards better quality of life, there is a great claim for medicinal plants. Carissa carandas l. plant popularly used as a traditional medicinal plant over thousands of years in the Ayurvedic, Unani, and Homoeopathic system of medicine. The major bioactive elements, which impart the medicinal worth of herbs, are alkaloids, flavonoids, saponins, and huge amounts of cardiac glycosides, triterpenoids, phenolic compounds, and tannins. Traditionally, the whole plant and its parts were used in the treatment of various ailments. It contains several phytochemical constituents belonging to the terpenoids category. The root is attributed to bitter, stomachic; antidiarrheal, vermifuge, and ant anthelmintic properties. The medicinally unripe fruit is used as an astringent. The ripe fruit is taken as an antiscorbutic and therapy for nausea. The leaf decoction is appreciated in cases of alternating fever, diarrhea, oral inflammation, and earache. Also, Carissa carandas have showing a extensive range of evidence for its cardiotonic, hepatoprotective, free radical scavenging and xanthine oxidase inhibitory, histamine-releasing, antirheumatic, antibacterial, antiviral, and anticonvulsant activity. A higher gross heat value of this species indicates its higher potential to be used as a good fuel source.
Keywords: Carissa carandas , Phytochemical Constituents, Traditional Use, Pharmacological Properties.
Cost Effective, Efficient and Stability indicating analytical method validation for Ranolazine related by Reverse Phase High Performance Liquid Chromatography in drug substances
Authors: Sharma Pushpendra , Satyanarayana KLV , Sri Hari G. 
Published: January 2021

A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Ranolazine in drug substances. Isocratic elution at a flow rate of 1.4ml/min was employed on Hypersil BDS C18, 150 x 4.6 mm, 5µm or Equivalent at 40°C column temperature. The mobile phase consisted of Mobile phase-A: Mobile phase-B (55:45) (Disodium hydrogen orthophosphate buffer with pH 7.0 and Acetonitrile). The UV detection wavelength was at 205 nm. Linearity was observed in concentration range of 0.07-0.82 ppm for ranolazine impurity-I and concentration range of 0.07-0.78 ppm for ranolazine impurity-II. The retention time for Ranolazine was 7.6 min. The method was validated for validation parameter like specificity, force degradation, linearity, accuracy, precision and robustness as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Ranolazine in pharmaceutical dosage forms.
Keywords: Ranolazine, Method Validation, Drug Substances, HPLC
Synthesized Silver Nanoparticle Loaded Gel of Curcuma Caesia for Effective Treatment of Acne
Authors: Rai Nivedita , Shukla Tarkeshwar P. , Loksh Kavita R. , Karole Sarita 
Published: January 2021

Objective: The objective of our research is to prepare silver nanoparticles from the rhizome extract of Curcuma caesia and develop topical herbal gel formulation for the effective treatment of acne. Methods: In this present study, silver nanoparticles were synthesized using hydroalcoholic extract of Curcuma caesia rhizome. Silver nanoparticles loaded gels were evaluated for pH, viscosity, spreadability, in vitro release, estimation of total flavonoids and alkaloid content and antibacterial (propioni bacterium acne) studies. Results: The synthesized silver nanoparticles were stable, spherical shape with average particle size of 220.5 nm. The results obtained in the developed formulation showed no lumps, had uniform color dispersion and were free from any fiber and particle. It was also observed to have easy washablity, good spreadability, pH was found to be 6.58±0.02 and 7.02±0.01 similar to pH of the skin. The antibacterial study of the developed formulation showed inhibitory activity against Propioni bacterium acne. Synthesized silver nanoparticle loaded gel displayed drug release of optimized formulation F3 follows the Higuchi kinetic model, and the mechanism is found to be non Fickian/anomalous according to Korsmeyer–Peppas. Silver nanoparticles effectively inhibited the growth of both microorganism indicating good antibacterial properties. Conclusion: Synthesis of silver nanoparticles using Curcuma caesia is a new, green method and not reported yet, as per literature survey done for this project. Successful synthesis and evaluation of silver nanoparticles was proved by the in-vitro study. Keywords: Curcuma caesia, Silver nanoparticles, Propioni bacterium acne, Acne, Flavonoids content, Alkaloid content, Antibacterial.
Acute renal artery thrombosis associated with the use of an oral contraceptive pill
Authors: El-Reshaid Kamel , Al-Bader Shaikha , Markova Zaneta 
Published: January 2021

Peripheral, and even visceral, venous thromboembolism is a known complication of oral contraceptive drugs (OCPs) but arterial disease, leading to renal infarction, is rarely reported. We describe a 36-year-old female patient who presented with sudden left loin pain for 2 days. Ultrasound examination showed a wedge-shaped echogenic lesion at lateral side of the left kidney. Computed tomography with contrast showed the area to be avascular and the arteriogram showed abrupt loss of the dorsal branch of left main renal artery, which lacked any deformities, confirming diagnosis of thrombosis-in-situe. Moreover, the pelvicalyceal system did not show abnormality which ruled out ascending infection. The patient did not have a family history or laboratory evidence of hypercoagulable disorder. An OCP was the only medication she had received in the previous 3 months. The OCP was discontinued, and the patient was treated with heparin for 3 days then Abixaban for 6 months. Subsequent CT study with contrast, 3 months later, showed lateral kidney scar. On follow up; she did not have subsequent thrombotic events up to 1 year.
Keywords: Abixaban, infarction, Kidney, oral contraceptive, thrombosis.
Assessing the Role of Modern Excipients for Delivery of Gold Nanoparticles
Authors: Waheed Abdul , Ghazal Nayela 
Published: January 2021

Using the drug delivery approach, we explain the role lipids and polymers perform in the delivery of gold nanoparticles. They were tested alongside drug and polymer compatibility using pharmacodynamics and pharmacokinetics. The collected data demonstrate the production of gold nanoparticles' stability and strong therapeutic effects. We illustrate some of the intriguing categories of targeting systems for the delivery of Au G Nanoparticles that are under development. Polymers containing reactive functional groups to combine targeting binding sites, cell receptors, or drugs are also coated with nanoparticles engineered for biomedical applications. The present review focuses on utilization of modern excipients, lipids, polymers in formulation of delivery systems that can efficiently delivery the gold nanoparticles. Gold nanoparticles have outranged in their use for treating wide health diseases with limited side effects. The next generation medical deliverables are majorly focused on gold nanoparticles.
Keywords: Gold nanoparticles, Lipids, Polymers, Delivery systems, Excipients, Diseases.
Assessment of Modern Excipients in Controlled Delivery of Proteins and Peptides
Authors: Munjulury Venkata Sai Dheeraj , Calico Robertina 
Published: January 2021

Polymeric micelles are highly proficient of modulating the function, distribution of drugs in the body, and can overcome biological barriers hence provoked as novel nanomedicine via various formulations. Current review emphasis on application of several polymers, biomaterials, lipids for the preparation of polymeric micelles formed by several molecular interactions between the block co-polymers and encapsulated molecules. Micellar carriers will be selected on basis of the type of polymer/payload interaction, which includes biological interface focused on the internal chemistry and fabrication of block-co polymers. Several features of these carriers can be manipulated to catering a broad range of drugs through active sensing of body targets. The fine-tuning of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level. To end with, the future perspective and impending challenges for polymeric micelles as nanomedicine are elaborated, anticipating prompting further innovations.
Keywords: Proteins, Peptides, Co-block Polymers, Lipids, Controlled, Drug Delivery.
UV SPECTROSCOPY DETERMINATION OF CILAZAPRIL AND HYDROCHLOROTHIAZIDE ACTIVE AGENTS USED IN THE TREATMENT OF HYPERTENSION
Authors: AKTAŞ A. Hakan 
Published: January 2021

Background: Antihypertensive and diuretic drugs are widely used in patients to regulate high blood pressure. Objective of current study was to prepare various cilazapril and hydrochlorothiazide mixtures, to create a matrix effect in the drug and to determine the determination of these active substances in drug samples after optimum conditions.
Method: In the spectrophotometric method, 100 mgL−1 solutions were prepared in cilazapril, hydrochlorothiazide in methanol + 0.1 m HCL solvent and then mixtures of these solutions were prepared between specific ppm. The absorbance’s of the solvent against the blind were read at 0.1 nm intervals. After the mixture, tablet (drug) sample was prepared and chemometrics methods were applied to the values obtained by saving the absorbance values.
Results: It was observed that the main component analysis applied as a result of spectrophotometric determination of various mixtures of cilazapril and hydrochlorothiazide used in the study gave correct results. These results were validated using various chemometric parameters.
Conclusion: The proposed chemometric method can be used in routine analysis in industrial laboratories.

Peer Review History:
Received 7 November 2020; Revised 8 Decembe; Accepted 4 January, Available online 15 January 2021
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file: Comments of reviewer(s):
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewer(s) detail:
Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com
Dr. U. S. Mahadeva Rao, Universiti Sultan Zainal Abidin, Terengganu Malaysia, raousm@gmail.com
Similar Articles:
VALIDATION OF HPLC AND UV VISIBLE METHODS FOR FEW SELECTED BLOOD PRESSURE LOWERING DRUGS AND THEIR FORMULATIONS
A Qualitative Evaluation of a Non-Thesis Graduate Program of Human Resources Development in Education
Authors: YİLDİRİM-TASTİ Ozlem , YILMAZ Elanur , ENGİN DEMİR Cennet , AKSU Meral 
Published: January 2021

Purpose: This study intended to evaluate Human Resources Development in Education program, a non-thesis graduate program offered within the Education Faculty of a public university located in Ankara, based on the perceptions of the stakeholders. Design/Methodology/Approach: In this qualitative evaluation study, the data were collected through a questionnaire, developed by the researchers, and semi-structured individual interviews. The questionnaire was administered to current students (n = 15) and available graduate students (n = 60). Later, a purposeful sampling method was used to select the participants for the interviews. In this regard, volunteer students (n = 5) and graduates (n = 20) of the program were involved in semi-structured individual interviews. The questionnaire was descriptively analyzed and presented in the form of frequencies and percentages. The qualitative data, on the other hand, were content analyzed. In doing so, codes were assigned to meaningful segments, and categories were generated through bringing the codes together which are listed as (1) the factors that affect participants’ preferences to the program; (2) the degree to which participants’ expectations from the program were met; (3) strengths of the program; (4) the difficulties encountered during the program; and (5) the aspects of the program that need improvement.
Findings: The findings reveal that professional development (n = 56) and the reputation of the university (n =56) are ranked among the chief factors affecting the participants’ enrollment in the program. In addition, the participants emphasized that the program was successful in meeting their expectations regarding personal interest (n = 54) and professional development (n = 49). Besides, despite the deficiencies such as internship and evening classes, it was unveiled that the program was found to be successful in equipping the students with the knowledge and skills specified in the field of human resources.
Highlights: The findings of this study are expected to contribute to the revising of the program. Besides, the results are expected to guide the development of similar programs and evaluation of the current programs within higher education institutions. Lastly, future studies might be conducted to reach enhanced findings through interviewing with also employers and conducting observations at workplaces of the students and graduates.
Implementasi Sistem Surveillance Berbasis Pengenalan Wajah pada STMIK STIKOM Indonesia
Authors: Putra I Nyoman Tri Anindia , Krisna Evi Dwi 
Published: January 2021

Sistem pengenalan wajah manusia merupakan salah satu bidang yang cukup berkembang dewasa ini, dimana aplikasi dapat diterapkan dalam bidang keamanan (security system) seperti ijin akses masuk ruangan, pengawasan lokasi (surveillance), maupun pencarian identitas individu pada database kepolisian. Penelitian ini bermaksud untuk merancang bangun sistem surveillance berbasis pengenalan wajah dengan menggunakan metode pengenalan wajah yang berfokus pada jarak dan akurasi dari pendeteksian wajah melalui kamera yang dapat dikenali melalui metode haarcascade classifier. Hasil dari penelitian dengan menggunakan metode tersebut memperoleh rata rata deteksi wajah dengan jarak maksimal adalah 3 meter dari kamera. Sedangkan hasil untuk akurasi pengenalan wajah dengan metode eigenface dan haarcascade classifier masing masing memperoleh akurasi 1 meter sebesar 87%, 2 meter sebesar 83%, dan 3 meter sebesar 63%.
Aplikasi Pengurus Daerah Dewan Masjid Indonesia Berbasis Android Untuk Mengembangkan Potensi Masjid Di Kota Semarang
Authors: Saraswati Galuh Wilujeng , Amar Rahmat Trinanda Pramudya 
Published: January 2021

Kemajuan Teknologi Informasi dan komunikasi memicu tumbuhnya komunikasi digital bebasis Internet of Things (IoT). Kondisi ini mendukung berkembangnya perangkat smartphone yang memiliki kemampuan kerja komputer dalam bentuk minimalis. Salah satu produk smartphone yang banyak digunkan saat ini adalah smartphone berbasis android.
Pengurus Daerah Dewan Masjid Indonesia (PD DMI) Kota Semarang mencoba manfaatkan kemajuan teknologi ini dengan membuat sebuah Aplikasi DMI Kota Semarang berbasis android untuk mengelola potesnsi masjid di di Kota Semarang. Tujuan dari penelitian ini adalah untuk mengelola semua informasi kepengurusan masjid daerah melalui sebuah Aplikasi DMI Kota Semarang berbasis Android, sehingga dapat digunakaan untuk mengembangkan potensi masjid dan bermanfaat untuk masyarakat sekitar.
Tahap pengemabangan aplikasi ini menggunakan metode rekaysa perangkat lunak waterfall yang diawali dengan analisa kebutuhan aplikasi meliputi kebutuan fungsional dan non fungsional. Hasil dari analisa ini akan menghasilkan sebuah desain sistem yang akan digunakan sebagai acuan pembangunan aplikasi yang meliputi penulisan kode program, perancangan UI/ UX, pengujian dan pemeliharaan sistem. Semua tahapan ini akan diterapkan kedalam pengembangan sistem agar menghasilkan aplikasi android yang mudah digunkaan oleh user (user friendly) dan mampu menyajikan data dan informasi masjid seluruh Kota Semarang secara cepat
Klasterisasi Data Travel Umroh di Marketplace Umroh.com Menggunakan Metode K-Means
Authors: Hermansyah Mas'ud , Hamdan Rifky Aditia , Sidik Fazar , Wibowo Arief 
Published: January 2021

Perjalanan wisata religi khususnya untuk ibadah umroh semakin diminati masyarakat. Umroh.com adalah jembatan antara calon jamaah umroh dengan travel umroh untuk bertransaksi didalam persiapan perjalanan ibadah umroh. Umroh.com sebuah perusajaan berbentuk marketplace dengan menawarkan produk paket umroh dan menyediakan travel umroh lebih dari 60 travel umroh terpercaya di Indonesia dengan izin resmi Kementrian Agama. Untuk dapat melakukan persaingan antar travel umroh, masing-masing travel membutuhkan strategi-strategi penjualan untuk dapat menarik minat calon jamaah umroh dan meningkatkan laba atau pendapatan perusahaan travel. Pada penelitian ini analisis data mining dilakukan dengan Teknik Clustering menggunakan metode K-Means. Hasil akhir dari penelitian ini adalah mengelompokkan data travel yang terdaftar di Umroh.com untuk mengetahui data travel yang memiliki potensi atau kecenderungan calon jamaah umroh dalam memilih travel umroh tersebut. Hasil penelitian menunjukkan bahwa pemodelan K-Means dengan jumlah klaster sebanyak 5 klaster memiliki nilai DBI terkecil yaitu sebesar 0,134.
Kata Kunci: Klasterisasi, Travel Umroh, Marketplace, K-Means, Davies Bouldin Index
Pengaruh Perbandingan Minyak dan Surfaktan serta Suhu terhadap Karakteristik Sediaan Krim
Authors: Hendrawan I Made Mas Oka , Suhendra Lutfi , Ganda Putra G.P. 
Published: January 2021

This study aims to determine the effect of oil and surfactant comparisons and the temperature to the resultant dosage characteristics and determine the oil and surfactant ratio and the appropriate temperature for the preparation of cream. This study uses the group random two-factor design. The first factor is the comparison of oil that is mixture of cocoa fat and virgin coconut oil with surfactants that is mixture of tween 80 and span 80 consisting of 3 levels, which are 85% ; 15%, 80% ; 20% and 85% ; 25%. The second factor is temperature consisting of 3 levels, which are 60 º C, 70 º C and 80 º C. Results of this study showed the treatment of oil comparison and surfactants were had an strongly effect to the homogeneity, adhesive time, spread ability, separation ratio and viscosity, but had no effect on the pH of cream preparations. Temperature treatment had an strongly effect on homogeneity, adhesive time, spread ability, separation ratio and viscosity, while only had an effect on the pH of a basic cream. Interaction between the treatment had an effect on the ratio of separation, pH as well as the spread of cream preparations, but no had effect on adhesive time and the viscosity of the preparation of cream. Oil comparison and surfactant treatment of 80%: 20% and temperature 70ºC is the best treatment resulting in a cream preparations with homogenity characteristics, adhesive time 7.14 Second, ratio of separator 0.48, spread ability of 6.83 cm, viscosity of 37000 cps and pH 6.05.
Keywords: oil, surfactans, temperature, cocoa fats, virgin coconut oil, tween 80 and span 80