bluuebunny/crossref_metadata_2025_split huggingface dataset:
Men’s sheds as community-based health promotion for men aged 50 plus: protocol for a mixed-methods systematic review
Authors: Albrecht Birte Marie , Foettinger Linda , Bammann Karin 
Published: August 2021

Abstract
Background
Men are less likely to participate in health promotion. One approach to reach men is the concept of men’s sheds. This community-based health promotion concept brings older men together to engage in joint activities. Prior research revealed various health-related effects of men’s sheds, such as benefits for well-being and mental health. To strengthen the current evidence base of men’s sheds, a mixed-methods systematic review analysing the association between participation and self-rated health, subjective well-being, and social isolation will be conducted. Moreover, information on how to successfully implement men’s sheds will be gathered.

Methods
This mixed-methods systematic review will follow the guidelines of the Joanna Briggs Institute (JBI). The databases MEDLINE (via PubMed), Scopus, Web of Science, and OpenGrey and the websites of men’s sheds associations will be searched for publications. Additionally, a hand search in the reference lists of the included publications will be conducted. Qualitative and quantitative studies published in English, German, or French will be considered for inclusion. The quality of the selected studies will be assessed using the JBI critical appraisal checklists. Following the convergent integrated approach, quantitative data will be transformed into textual descriptions, and subsequently combined with data from qualitative studies as well as from the qualitative components of mixed-methods studies in a simultaneous data synthesis.

Discussion
The results of this systematic review will lead to a comprehensive understanding of the current evidence base regarding the effectiveness of men’s sheds. Furthermore, they will provide useful implications for the implementation of men’s sheds.

Systematic review registration
PROSPERO CRD42020219390
Self-harm prevalence and associated factors among street children in Mashhad, North East of Iran
Authors: Jarahi Lida , Dadgarmoghaddam Maliheh , Naderi Atiyeh , Ghalibaf AmirAli Moodi 
Published: August 2021

Abstract
Background
Self-harm is intentional harmful behavior in the context of emotional distress. Street children are boys and girls under eighteen who are forced to work or live on the streets. These children are exposed to violent situations and high-risk behaviors like self-harm. This study investigated the prevalence of self-harm in street children in Mashhad, the second Metropolis of Iran.

Methods
In this cross-sectional study, 98 children were assessed with a 22-item of self-harm Inventory (SHI) questionnaire. A trained social worker interviewed the participants who were referred to Mashhad Welfare Office, February-July 2020.

Results
The mean age of participants was 13.8 (2.3) years old, and 71.4 % of them were male. Of street children 59.2 % have had self-harming behavior, among them 8.6 % had one self-harming behavior, and others have more than one. The self-harmed people who had physical injuries, more frequent injuries were hitting (26.5 %), self-starvation (23.5 %), cutting (21.4 %), respectively. In comparison, common psychological injuries were God-distancing (29.6 %) and self-defeating thoughts (19.4 %). The most important risk factors were having a mental disorder (OR = 6.3, P = 0.002), losing parents (OR = 4.4, P = 0.01), self-harming or suicide history in relatives (OR = 3.2, P = 0.001, OR = 4.3, P = 0.03 respectively), low-educated parents (OR = 4.2, P = 002, OR = 2.8, P = 0.02 for father and mother respectively), and age-increasing (OR = 1.5, P = 0.001).

Conclusions
The prevalence of self-harming in street children is significantly high. Some of these children are in more high-risk conditions that face them to suffer from self-harming at a younger age. Family factors are more important in predicting self-harming and community health decision-makers should provide educational interventions and psychological support for these children and their families.
Specific inhibition of Streptococcus bovis by endolysin LyJH307 supplementation shifts the rumen microbiota and metabolic pathways related to carbohydrate metabolism
Authors: Kim Hanbeen , Park Tansol , Kwon Inhyuk , Seo Jakyeom 
Published: August 2021

Abstract
Background
Endolysins, the bacteriophage-originated peptidoglycan hydrolases, are a promising replacement for antibiotics due to immediate lytic activity and no antibiotic resistance. The objectives of this study were to investigate the lytic activity of endolysin LyJH307 against S. bovis and to explore changes in rumen fermentation and microbiota in an in vitro system. Two treatments were used: 1) control, corn grain without LyJH307; and 2) LyJH307, corn grain with LyJH307 (4 U/mL). An in vitro fermentation experiment was performed using mixture of rumen fluid collected from two cannulated Holstein steers (450 ± 30 kg) and artificial saliva buffer mixed as 1:3 ratio for 12 h incubation time. In vitro dry matter digestibility, pH, volatile fatty acids, and lactate concentration were estimated at 12 h, and the gas production was measured at 6, 9, and 12 h. The rumen bacterial community was analyzed using 16S rRNA amplicon sequencing.

Results
LyJH307 supplementation at 6 h incubation markedly decreased the absolute abundance of S. bovis (approximately 70% compared to control, P = 0.0289) and increased ruminal pH (P = 0.0335) at the 12 h incubation. The acetate proportion (P = 0.0362) was significantly increased after LyJH307 addition, whereas propionate (P = 0.0379) was decreased. LyJH307 supplementation increased D-lactate (P = 0.0340) without any change in L-lactate concentration (P > 0.10). There were no significant differences in Shannon’s index, Simpson’s index, Chao1 estimates, and evenness (P > 0.10). Based on Bray-Curtis dissimilarity matrices, the LyJH307 affected the overall shift in microbiota (P = 0.097). LyJH307 supplementation induced an increase of 11 genera containing Lachnoclostridium, WCHB1–41, unclassified genus Selenomonadaceae, Paraprevotella, vadinBE97, Ruminococcus gauvreauii group, Lactobacillus, Anaerorhabdus furcosa group, Victivallaceae, Desulfuromonadaceae, and Sediminispirochaeta. The predicted functional features represented by the Kyoto Encyclopedia of Genes and Genomes pathways were changed by LyJH307 toward a decrease of carbohydrate metabolism.

Conclusions
LyJH307 caused a reduction of S. bovis and an increase of pH with shifts in minor microbiota and its metabolic pathways related to carbohydrate metabolism. This study provides the first insight into the availability of endolysin as a specific modulator for rumen and shows the possibility of endolysin degradation by rumen microbiota.
Feasibility study of fracture interpretation using multicomponent seismic data: SEAM Phase II Barrett model
Authors: Liu Youfang , Simmons James 
Published: August 2021

Several P-wave azimuthal anisotropy studies have been conducted for the SEG Advanced Modeling Program Phase II Barrett model data. However, these analyses provide fracture property estimation that is inconsistent with the actual model properties. Therefore, we perform a feasibility study to understand the influence of the overburden and reservoir properties, and processing and inversion steps, which together determine the success of the fracture interpretation from seismic data. The 1D model properties (orthorhombic for overburden and reservoir) are first extracted from the actual Barrett model properties at two locations. Anisotropic prestack reflectivity modeling exposes the true orthorhombic response of the 1D medium in the form of common-offset and common-azimuth gathers. The true anisotropic response is obscured in the Barrett data (generated by finite-element modeling) due to the mild lateral velocity variations and orthorhombic anisotropy in the overburden. We then expose the reservoir anisotropic response using an isotropic overburden in the reflectivity modeling. This indicates that the P-wave velocity variation with azimuth (VVAZ) responses generated by the reservoir itself are weak, which leads to an unstable VVAZ inversion to estimate the interval normal moveout (NMO) velocity anisotropy. The reservoir thickness (125 m or 65 ms of two-way traveltime) or NMO velocity anisotropy (6%–7%) needs to be at least doubled to obtain a stable VVAZ inversion. Anisotropic geometric-spreading correction improves the amplitude variation with azimuth inversion results when reflectivity modeling models the orthorhombic overburden. The converted wave (C-wave) has a stronger VVAZ response compared to that of the P-wave. We suggest that the C-wave data could be useful to constrain fracture interpretation in the Barrett model. We conclude that the results of previous studies are due to the combination of the residual influence of overburden after processing and imaging and the weak anisotropy responses from the reservoir.
The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis
Authors: DeJong Caitlin S. , Dichmann Darwin S. , Exner Cameron R. T. , Xu Yuxiao , Harland Richard M. 
Published: August 2021

ABSTRACT
The FET family of atypical RNA-binding proteins includes Fused in sarcoma (FUS), Ewing's sarcoma (EWS) and the TATA-binding protein-associate factor 15 (TAF15). FET proteins are highly conserved, suggesting specialized requirements for each protein. Fus regulates splicing of transcripts required for mesoderm differentiation and cell adhesion in Xenopus, but the roles of Ews and Taf15 remain unknown. Here, we analyze the roles of maternally deposited and zygotically transcribed Taf15, which is essential for the correct development of dorsoanterior neural tissues. By measuring changes in exon usage and transcript abundance from Taf15-depleted embryos, we found that Taf15 may regulate dorsoanterior neural development through fgfr4 and ventx2.1. Taf15 uses distinct mechanisms to downregulate Fgfr4 expression, namely retention of a single intron within fgfr4 when maternal and zygotic Taf15 is depleted, and reduction in the total fgfr4 transcript when zygotic Taf15 alone is depleted. The two mechanisms of gene regulation (post-transcriptional versus transcriptional) suggest that Taf15-mediated gene regulation is target and co-factor dependent, contingent on the milieu of factors that are present at different stages of development.
The body cannot be cheated: sexual practices and modern contraceptive use among street-involved young people in two South West States in Nigeria
Authors: Obiyan Mary O. , Olaleye Atinuke O. , Ijadunola Macellina Y. , Folayan Morenike O. 
Published: August 2021

Background: Young people aged 10-24 years constitute about one-third of the total population of Nigeria. Street-involved young people (SIYP) face a double burden of living condition instability and lack of adequate parental monitoring. This leaves them vulnerable to poor sexual and reproductive health (SRH) choices and behaviour. Risky sexual behaviour with poor access to SRH information and interventions increases their vulnerability to adverse SRH outcomes. This study explored the use of modern contraceptives and sexual practices among male and female SIYP (10-24 years) in Nigeria. Methods: This qualitative study used an exploratory research design to guide the development of the focus group discussion (FGD) and in-depth interview (IDI) guides. Participants were asked questions on background information, lived experiences and SRH practices. The FGDs were stratified by sex and age. Both FGD discussions and IDI interviews were recoded; transcripts were transcribed and translated from local dialect into English language. Content analysis was conducted thematically with the aid of NVivo. Results: In total, 17 IDIs and 11 FGDs were conducted among SIYP aged 10-24 years. The total number of respondents interviewed was 109. There is high awareness of modern contraceptives among SIYP; the commonly known method was condom with a few also aware of emergency contraceptives pills. However, participants reported low use of modern contraceptives. The common reasons alluded for not using condoms were reduced sexual pleasure, cost and associated myths. The five themes that emerged under sexual practices of SIYP included early age at first sexual encounter, multiple sex partners, transactional sex, same-sex relationships, and transactional sex. Conclusions: There is low utilization of contraceptives by SIYP against the background of their high-risk sexual practices. SIYP would benefit from free contraceptive education, social safety nets and interventions to dissuade them from transactional sex and other unhealthy sexual practices.
Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy
Authors: Sarfraz Shiza , Rafique Hamza , Ali Hassam , Hassan Syed Zawahir 
Published: August 2021

Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.
The association of socio-demographic and environmental factors on childhood diarrhea in Cambodia
Authors: Pisey Vong , Banchonhattakit Pannee , Laohasiriwong Wongsa 
Published: August 2021

Background:Diarrhea is still the leading cause of childhood death worldwide, as well as a major cause for concern in developing countries. This study was conducted to investigate the factors related to childhood diarrhea in Cambodia. Methods:A cross-sectional study of the secondary data from the Cambodia Demographic and Health Survey 2014 was conducted using the combined dataset of household data and children’s data. A generalized linear mixed model was used to analyze the determinant factors of childhood diarrhea. Results:The surveys included 2,828 children, aged 12 to 35 months. The prevalence of diarrhea in the last 2 weeks was 16.44% (95% CI: 14.72%-18.31%). Factors with statistically significant associations with childhood diarrhea in Cambodia were: maternal unemployment, compared with being in employment (AOR = 1.43; 95% CI: 1.14-1.78); the child being male (AOR = 1.25; 95%CI: 1.02-1.53); the presence of unimproved toilet facilities (AOR = 1.17; 95%CI: 1.05-1.31) compared with improved toilet facilities; and unhygienic disposal of children’s stools (AOR = 1.32; 95%CI: 1.06-1.64) compared with hygienic disposal of children’s stools when controlling for other covariates. Both maternal age (one year older; AOR = 0.85; 95%CI: 0.78– 0.93) and child age (one month older; AOR = 0.86; 95%CI: 0.78-0.94) had significant negative associations with the occurrence of childhood diarrhea. Conclusion:Childhood diarrhea remains a public health concern in Cambodia. The probability of diarrhea occurring is shown to be increased by maternal unemployment, the sex of the child being male, lack of provision of improved toilet facilities, and the unhygienic disposal of children’s stools; whereas increasing maternal age and child’s age were associated with a reduced chance of diarrhea occurring. On the basis of these results, we recommend provision of programs focusing on reducing diarrhea through the construction of improved toilet facilities and the promotion of behavior to improve hygiene, specifically targeting younger mothers.
Trap of weights: The reuse of weights in the floating catchment area (FCA) methods to measuring accessibility
Authors: Zhang Lina 
Published: August 2021

Background: Geographic weights are vital in the floating catchment area (FCA) method of accessibility measurements due to their simulation of spatial barriers in various ways. When modelling population demand, geographical weights with different distance decay coefficients can reflect diverse distance tolerances in facility utilization and could lead to erratic accessibility results. Quantifying accessibility as the sum of weighted supply-demand ratios can alleviate the distance decay coefficient's influence and generate stable geographic patterns. However, the effects of weighted ratios on different FCA models and resources have not been investigated. Methods: To identify impacts of weighted ratios on various FCA variants, this study contrasted the accessibility calculated from the sum of ratios (access) and the sum of weighted ratios (access ratios) within three prevalent FCA models: enhanced two-step FCA (E2SFCA), modified two-step FCA (M2SFCA), and three-step FCA (3SFCA). In addition, the accessibilities of various resources evaluate the stability of the weighted ratios' effect. This study therefore examined the accessibilities to primary schools, job opportunities, and major hospitals in Shanghai. Shanghai is a case study that provides lessons on using big data to measure accessibility in metropolitan areas. Results: Geographic weights can not only mitigate the impact of the distance decay coefficients, but can also eliminate model features, which reduces the performance of the M2SFCA's supply decay and the 3SFCA's population demand adjustment in accessibility results. Moreover, weighted ratios tend to overestimate accessibility in marginal communities that lie within fewer catchments, regardless of the resource type. This tendency can lead to an epistemological trap that creates an inaccurate and counter-intuitive perception of resource distribution in a given area. Conclusions: The results identify a gap between the methodological logic and the empirical perception in accessibility measurements. This study concludes that the use of geographic weights needs to be cautious and epistemologically consistent.
Simple statistical insights into the COVID-19 data of Saudi Arabia: figures prior to vaccination campaign
Authors: El-Masry Omar S. 
Published: August 2021

Background: COVID-19, the disease caused by the newly emerging coronavirus, SARS-COV2, is still a major health burden worldwide as it continues to spread rapidly in many countries after being contained for a while. The aim of the study was to analyze the official current disease estimates in the Kingdom of Saudi Arabia to anticipate future risks and needs. Methods: Publicly available COVID-19 data published by the Saudi Ministry of Health were analyzed to extract statistical estimates of the disease. These include monthly case fatality rates, death rates/1000, comparison of death figures and regression analysis. Results: The number of confirmed, recovered and deaths surged in the middle of the outbreak (June and July). The case fatality rates reported later in September-November were the highest despite the decline in the number of confirmed cases. The death rates/1000 were higher during the middle of the outbreak, where the highest numbers of deaths were recorded. The number of recovered cases was the highest as well during this time. Regression analysis showed that the number of deaths was related to that of confirmed cases, especially during the peak time. On the other hand, the number of recovered cases was related to that of confirmed cases at the beginning of the outbreak. Conclusion: Statistical estimates of COVID-19 fatalities provide simple figures to understand the disease progression pattern and the health care management success in disease containment. However, the absolute numbers should never be disregarded to reflect on the real situation.
Brain-derived neurotrophic factor, nerve growth factor, and high sensitivity C-reactive protein levels in urine in overactive bladder patients: a meta-analysis
Authors: Utomo Edwin , . Farhat , Barus Melvin Nova Gunawanto , Tala Mohd. Rhiza Z. 
Published: August 2021

Background: Overactive bladder (OAB) is a clinical syndrome characterized by a combination of symptoms including urgency, frequency, and nocturia, with or without urinary incontinence. Overactive bladder has a high prevalence especially in those of an older age and women, with diagnosis depending on the patient’s symptoms. This study aims to assess brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and high sensitivity C-reactive protein (HSCRP) in urine as biomarkers in OAB. Methods: Studies were searched from Pubmed, Science Direct, Wiley Online Library, and Google Scholar. All studies assessing BDNF, NGF, and HSCRP in urine in OAB patients were included. The standardized mean difference (SMD) and 95% confidence intervals (CI) were then calculated. Results: A total of 85 studies were included with a total of 11,483 subjects (6,885 OAB patients and 4,598 controls). Based on data analysis results, urinary NGF/Creatinine (NGF/Cr) and NGF level in OAB patients were significantly higher than control (SMD = 1.00, 95%CI = 0.80-1.20, P<0.00001; and SMD = 1.11, 95%CI = 0.79-1.43, P<0.00001). NGF/Cr level was found higher in OAB with incontinence (OAB wet) compared with OAB without incontinence (OAB dry) (SMD = 0.41, 95%CI = 0.23-0.60, P<0.0001), and decreased after treatment (SMD = 0.76, 95%CI = 0.49-1.03, P<0.00001). Urinary BDNF/Cr level was significantly higher in OAB patients compared with controls (SMD = 1.97, 95%CI = 1.14-2.79, P<0.00001), and also decreased significantly after treatment (SMD = 0.75, 95%CI = 0.42-1.08, P<0.00001). The level of HSCRP was significantly higher in OAB patients when compared with controls (SMD = 0.38, 95%CI = 0.12-0.64, P<0.004). Conclusions: The level of BDNF/Cr, NGF/Cr, NGF, and HSCRP in urine were found higher in OAB compared with controls, which means they may be used as a biomarkers for OAB.