bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanocarriers Loaded with Oxygen to Improve the Protection of the Heart to be
Transplanted
Authors: Penna Claudia , Trotta Francesco , Cavalli Roberta , Pagliaro Pasquale 
Published: November 2021

:
In the case of serious cardiovascular diseases, such as refractory heart failure, heart transplantation is
the only possible intervention. Currently, the modes of organ transport in hypothermic cardioplegic solution do
not allow the implantation of the heart beyond 4-5 hours from the explant. The heart being an organ with a
greater consumption of oxygen and high metabolism than the brain, its transport in hypothermic cardioplegic solutions
presents critical issues in terms of time and conservation. An ambitious goal of many researchers and
clinicians is to minimize the hypoxia of the explanted heart and extend the permanence time in cardioplegic solution
without damage from hypoxia. Adequately oxygenating the explanted organs may extend the usability
time of the explanted organ. This challenge has been pursued for years with approaches that are often expensive,
risky, and/or difficult to use. We propose to consider oxygenated nanocarriers releasing oxygen for a long
time. In this way, it will also be possible to use organs from distant countries with respect to the recipient, thus
exceeding the canonical 4-5 hours tolerated up to now. In addition to the lack of oxygen, the transplanted organ
can undergo the accumulation of catabolites due to the lack of perfusion during transport. Therefore, nanocarriers
can also be perfused in adequate solution during organ transportation. A better oxygenation improving the
postoperative recovery of the transplanted heart will improve the recipient's quality of life.
MiR-582-5p Attenuates Neonatal Hypoxic-ischemic Encephalopathy by
Targeting High Mobility Group box 1 (HMGB1) through Inhibiting Neuroinflammation
and Oxidative Stress
Authors: Yang Guang , Xue Zhimin , Zhao Yuan 
Published: November 2021

Background:
MiR-582-5p has been demonstrated to protect against ischemic stroke.
However, its implication in the progression of neonatal hypoxic-ischemic encephalopathy (HIE)
has not been explored.

Methods:
In this study, we used an in vitro model of oxygen-glucose deprivation (OGD) to investigate
the protective effect of miR-582-5p on PC12 cells. OGD-induced inhibition of cell viability
and promotion of cell death was assessed by CCK-8 assay and flow cytometry. Real-time PCR and
enzyme-linked immunosorbent assay (ELISA) were utilized to examine the levels of inflammatory
cytokines. The effects of miR-582-5p on OGD-induced oxidative injury were assessed by the determination
of oxidative stress indicators. Furthermore, dual-luciferase reporter assay and gain-offunction
assay were used to determine the mechanism of miR-582-5p in OGD-induced cell injury.

Results :
The expression of miR-582-5p was reduced upon OGD treatment in PC12 cells. Overexpression
of miR-582-5p inhibited OGD-induced PC12 cell injury by regulating cell viability, apoptosis,
inflammatory responses, and oxidative stress. MiR-582-5p targeted and negatively regulated
high mobility group box 1 (HMGB1). MiR-582-5p presented protective effects on OGD-induced
PC12 cell injury by targeting HMGB1.

Conclusion:
Our results indicated that miR-582-5p ameliorates neuronal injury by inhibiting apoptosis,
inflammation, and oxidative stress through targeting HMGB1.
Garlic (Allium sativum L.): Its Chemistry, Nutritional Composition, Toxicity,
and Anticancer Properties
Authors: Rauf Abdur , Abu-Izneid Tareq , Thiruvengadam Muthu , Imran Muhammad , Olatunde Ahmed , Shariati Mohammad Ali , Bawazeer Saud , Naz Saima , Shirooie Samira , Sanches-Silva Ana , Farooq Umar , Kazhybayeva Galiya 
Published: November 2021

:
The current review discuss the chemistry, nutritional composition, toxicity, and biological
functions of garlic and its bioactive compounds against various types of cancers via different anticancer
mechanisms. Several scientific documents were found in reliable literature and searched in
databases viz Science Direct, PubMed, Web of Science, Scopus, and Research Gate were carried
out using keywords such as “garlic”, “garlic bioactive compounds”, “anticancer mechanisms of garlic”,
“nutritional composition of garlic”, and others. Garlic contains several phytoconstituents with
activities against cancer, and compounds such as diallyl trisulfide (DATS), allicin, and diallyl disulfide
(DADS), diallyl sulfide (DAS), and allyl mercaptan (AM). The influence of numerous garlic-
derived products, phytochemicals, and nanoformulations on the liver, oral, prostate, breast, gastric,
colorectal, skin, and pancreatic cancers has been studied. Based on our search, the bioactive
molecules in garlic were found to inhibit the various phases of cancer. Moreover, the compounds
in this plant also abrogate the peroxidation of lipids, activity of nitric oxide synthase, epidermal
growth factor (EGF) receptor, nuclear factor-kappa B (NF-κB), protein kinase C, and regulate cell
cycle and survival signaling cascades. Hence, garlic and its bioactive molecules exhibit the aforementioned
mechanistic actions, and thus, they could be used to inhibit the induction, development,
and progression of cancer. The review describes the nutritional composition of garlic, its bioactive
molecules, and nanoformulations against various types of cancers, as well as the potential for developing
these agents as antitumor drugs.
Recent Progress in Oleanolic Acid: Structural Modification and Biological
Activity
Authors: Wang Wang , Li Yutong , Li Yan , Sun Dejuan , Li Hua , Chen Lixia 
Published: November 2021

Abstract:
Natural products have been proven as the main source of biologically active compounds, which are potentially useful for drug development. As one of the most studied pentacyclic triterpenes, oleanolic acid (OA) exhibits a broad range of biological activities and serves as a good scaffold for the development of novel derivatives that could be vital in drug discovery for various ailments. Till now, many of its derivatives with multiple bioactivities have been prepared through chemical modifi-cation. This review summarizes the recent reports of OA derivatives (2016-present) and their biologi-cal effects and action mechanisms in vitro and in vivo models, and discusses the design of novel and potent derivatives.
Advances in PPARs Molecular Dynamics and Glitazones as a Repurposing
Therapeutic Strategy through Mitochondrial Redox Dynamics against
Neurodegeneration
Authors: Durai Priya , Beeraka Narasimha M. , Ramachandrappa Hemanth Vikram Poola , Krishnan Prakash , Gudur Pranesh , Raghavendra Nulgumnalli Manjunathaiah , Ravanappa Prashantha Kumar Bommenahally 
Published: November 2021

:
Peroxisome proliferator-activated receptors (PPARs) activity has significant implications
for the development of novel therapeutic modalities against neurodegenerative diseases. Although
PPAR-α, PPAR-β/δ, and PPAR-γ nuclear receptor expressions are significantly reported in the
brain, their implications in brain physiology and other neurodegenerative diseases still require extensive
studies. PPAR signaling can modulate various cell signaling mechanisms involved in the
cells contributing to on- and off-target actions selectively to promote therapeutic effects as well as
the adverse effects of PPAR ligands. Both natural and synthetic ligands for the PPARα, PPARγ, and
PPARβ/δ have been reported. PPARα (WY 14.643) and PPARγ agonists can confer neuroprotection
by modulating mitochondrial dynamics through the redox system. The pharmacological effect of
these agonists may deliver effective clinical responses by protecting vulnerable neurons from Aβ
toxicity in Alzheimer’s disease (AD) patients. Therefore, the current review delineated the ligands’
interaction with 3D-PPARs to modulate neuroprotection, and also deciphered the efficacy of numerous
drugs, viz. Aβ aggregation inhibitors, vaccines, and γ -secretase inhibitors against AD; this
review elucidated the role of PPAR and their receptor isoforms in neural systems, and neurodegeneration
in human beings. Further, we have substantially discussed the efficacy of PPREs as potent
transcription factors in the brain, and the role of PPAR agonists in neurotransmission, PPAR gamma
coactivator-1α (PGC-1α) and mitochondrial dynamics in neuroprotection during AD conditions.
This review concludes with the statement that the development of novel PPARs agonists may benefit
patients with neurodegeneration, mainly AD patients, which may help mitigate the pathophysiology
of dementia, subsequently improving overall the patient’s quality of life.
Thiophene Ring-opening Reactions III: One-Pot Synthesis and Antitumor Activity of 1,3,4-Thiadiazoline–Benzothiazolo[3,2-b]pyridazine Hybrids†
Authors: Abdullah Ahmad H. , Zahra Jalal A. , Sabri Salim S. , Awwadi Firas F. , Abadleh Mohammed M. , Abdallah Qasem M. , El-Abadelah Mustafa M. 
Published: November 2021

Introduction:
The preparation of model 6-chloro-5-nitrothieno[2,3-c]pyridazines incorporating (2'-halo-5'-nitrophenyl) entity is described. Interaction of these substrates with N'-(aryl)benzothiohydrazides, in the presence of triethylamine, followed a formal [4+1] annulation, furnishing the respective 1,3,4-thiadiazoline–benzothiazolo [3,2-b]pyridazine hybrids directly. This one-pot synthesis implies thiophene ring-opening and two consecutive intramolecular cyclizations. The structures of the synthesized new hybrids are supported by MS, NMR, and IR spectral data and further confirmed by single-crystal X-ray diffraction. These hybrids exhibit antiproliferative activity with notable selectivity against solid tumor cell lines (IC50: 4-18 μM).

Aims:
This study aimed at exploring the scope and applicability of thiophene ring-opening reaction towards the synthesis of new thiadiazoline–[fused]tricyclic conjugates.

Background:
α-Chloro-β-nitrothienopyridazine underwent ring-opening upon reacting with N'-(aryl)benzothiohydrazides generating 1,3,4-thiadiazoline–benzothiazolo[3,2-b]pyridazines.

Objective:
This new thiophene ring-opening reaction is applied to the one-pot synthesis of thiadiazoline–benzothiazolo[3,2-b]pyridazine couples.

Method:
A direct interaction of α-chloro-β-nitrothienopyridazine with N'-(aryl)benzothio-hydrazide at room temperature for 1-2 h occurred.

Result:
α-Chloro-β-nitrothieno[2,3-c]pyridazines are suitable substrates for the facile synthesis of thiadiazoline–benzothiazolo[3,2-b]pyridazine hybrids.

Conclusion:
This novel ring-opening reaction proceeds via formal [4+1] annulation and provides a versatile approach to various conjugated and/or fused five-membered heterocycles.
Type 1 Diabetes in Pregnancy: A Review of Complications and Management
Authors: Huda Mohammed S.B. , Jaffar Farah , Laycock Kate 
Published: November 2021

Background:
Pre-gestational diabetes can pose significant risk to the mother and infant,
thus requiring careful counselling and management. Since Saint Vincent’s declaration in 1989, adverse
maternal and fetal outcomes, such as preeclampsia, perinatal mortality, congenital anomalies,
and macrosomia, continue to be associated with type 1 diabetes. Although pregnancy is not considered
an independent risk factor for the development of new onset microvascular complications, it is
known to exacerbate pre-existing microvascular disease. Strict glycaemic control is the optimal management
for pre-existing type 1 diabetes in pregnancy, as raised HbA1C is associated with increased
risk of maternal and fetal complications. More recently, time in range on Continuous Glucose
Monitoring glucose profiles has emerged as another useful evidence-based marker of fetal outcomes.

Objective:
This review summarises the complications associated with pre-gestational type 1 diabetes,
appropriate evidence-based management, including preparing for pregnancy, intrapartum
and postpartum care.

Methods:
A structured search of the PubMed and Cochrane databases was conducted. Peer-reviewed
articles about complications and management guidelines on pre-gestational type 1 diabetes
were selected and critically appraised.

Results:
One hundred and twenty-three manuscripts were referenced and appraised in this review,
and international guidelines were summarised.

Conclusion:
This review provides a comprehensive overview of the recurring themes in the literature
pertaining to type 1 diabetes in pregnancy: maternal and fetal complications, microvascular disease
progression, and an overview of current guideline-specific management.
Research Progress on Pulverized Coal Concentration Detection Device
Authors: Wu Yun-Tao , Wang Tian-Hu , Hua Jin , Sun He-Yuan 
Published: November 2021

Background:
Pulverized coal detection is an indispensable detection measure in the coal
industry. The current detection devices can be divided into two types: invasive and non-invasive.
The coal dust detection methods and devices based on acoustics, optics, and electricity have been
extensively studied. In order to achieve a high-efficiency online detection scheme, improving the
accuracy and stability of the detection means is the primary goal of the research.

Objective:
The general problems and characteristics of coal dust detection device design are summarized,
as well as recent technological developments and the need for online testing to predict future
research trends.

Methods:
The current typical detection devices are classified according to the detection principle
and whether they invade the target, analyzing its advantages and disadvantages according to the device
performance and application scenarios.

Results:
It has a beneficial effect on the design of the pulverized coal concentration detection device.

Conclusion:
The paper summarizes and analyzes several representative coal concentration detection
device patents in recent years. Then it points out advantages and main problems. On this basis, the
main development direction of the coal dust concentration detection device in the future is discussed.
Palbociclib versus abemaciclib in HR+/HER2- advanced breast cancer: an indirect comparison of patient-reported end points
Authors: Law Ernest , Gavanji Roya , Walsh Sarah , Haltner Anja , McTavish Rebecca , Cameron Chris 
Published: November 2021

Aim:
To assess the relative impact of palbociclib plus fulvestrant (PAL + FUL) and abemaciclib plus fulvestrant (ABEM + FUL) on patient-reported outcomes in patients with hormone receptor-positive, HER2-negative (HR+/HER2-) advanced breast cancer.
Patients & methods:
Anchored matching-adjusted indirect comparisons were conducted using individual patient data from PALOMA-3 (PAL + FUL) and summary-level data from MONARCH-2 (ABEM + FUL). Outcomes included the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 items (EORTC QLQ-C30) and its breast cancer-specific module (QLQ-BR23).
Results:
Significantly different changes from baseline favoring PAL + FUL compared with ABEM + FUL were observed in global quality of life (6.95 [95% CI: 2.19–11.71]; p = 0.004) and several functional/symptom scales, including emotional functioning, nausea/vomiting, appetite loss, diarrhea and systemic therapy side effects.
Conclusion:
PAL + FUL was associated with more favorable patient-reported outcomes than ABEM + FUL in patients with HR+/HER2- advanced breast cancer.
La imagen construida a partir del discurso. Foro inseguridad vs seguridad: el caso del cierre de calles en Ciudad Juárez
Authors: Méndez Aranda Nibia Verónica 
Published: November 2021

En atención a los incrementos de homicidios registrados por el INEGI y CONAPO en Ciudad Juárez, Chihuahua, México, durante el 2008 se registró una alza respecto a los años anteriores reportando una estadística de 1,569 ejecuciones, los cuales aumentaron a 2,372 durante el 2008, año donde se alcanzó su máxima representación, seguido del año 2010 con unos 2,218 homicidios y en el 2011 con 2,015 dentro de este territorio. A finales del año de 2007 al 2012, el Plan Estratégico de Ciudad Juárez (asociación civil) convocó a través de la Red de Vecinos a debatir el problema de la inseguridad para dialogar con representantes de instancias gubernamentales, los ciudadanos y líderes de las calles cerradas. Y así analizar la realidad de la frontera con la finalidad de conocer sus derechos y posturas en relación a la inseguridad. El proceso de transformación y apropiación del territorio que tiene como peculiaridad inicial el cercado por iniciativa de los propios vecinos, mediante la instalación de barreras físicas y simbólicas en busca de una mayor seguridad. Esto es una reacción de autodefensa que representa a sensación de miedo por parte de los sujetos que lo habitan al sentirse desprotegidos.Se presenta un análisis del discurso en base a los relatos expuestos a partir de lo que gente habla en relación con sus sentimientos, apoyado por la semántica de los diferentes textos que analizan su contenido para poder conocer la situación de miedo, inseguridad y violencia de Ciudad Juárez a través de imaginario urbano que se simboliza con el cierre de calles por medio de las diferentes percepciones y respuestas subjetivas de los vecinos e integrantes del foro.
Repoblamiento de macro algas en áreas de usos intensivos como oportunidad de recuperación de servicios ambientales en espacios degradados
Authors: Baeza Sequeira Marcelo 
Published: November 2021

Grandes esfuerzos se han realizado por parte del Estado para la protección de ecosistemas que prestan valiosos servicios ambientales, a través de diversas figuras de áreas protegidas, existiendo para ello marcos regulatorios en constante revisión. Estos se concentran en áreas que se puedan reservar para un uso preferente de conservación. Por otra parte, existen también intentos para la recuperación de especies que constituyen recursos económicos de los cuales dependen una comunidad o una actividad económica determinada. Pero cuando se trata de ecosistemas en lugares que soportan usos intensivos distintos a los servicios eco sistémicos originales no se ve una orgánica similar que vele por su cuidado o restauración. Un proyecto de repoblamiento de macroalgas en áreas de usos intensivo se presenta como una oportunidad de recuperación de servicios ambientales en espacios degradados, pero para su éxito debe sortear la dificultad de no contar con un marco regulatorio que avale dicha recuperación. Un cambio normativo que facilite e incentive la recuperación de ecosistemas es una oportunidad para resolver diversos conflictos ambientales.
Changes in the Prevalence of Symptoms of Depression, Loneliness, and Insomnia in U.S. Older Adults With Type 2 Diabetes During the COVID-19 Pandemic: The Look AHEAD Study
Authors: Chao Ariana M. , Wadden Thomas A. , Clark Jeanne M. , Hayden Kathleen M. , Howard Marjorie J. , Johnson Karen C. , Laferrère Blandine , McCaffery Jeanne M. , Wing Rena R. , Yanovski Susan Z. , Wagenknecht Lynne E. 
Published: November 2021

OBJECTIVE
To evaluate changes in the prevalence of depressive symptoms, loneliness, and insomnia among older adults with type 2 diabetes from 2016 to 2020 and to assess risk factors for these conditions including demographics, multimorbidity, BMI, treatment group, and pre-coronavirus 2019 (COVID-19) measure scores.

RESEARCH DESIGN AND METHODS
This was a prospective, observational study of participants from the Look AHEAD (Action for Health in Diabetes) cohort study. Data were from two assessments before COVID-19 (visit 1: April 2016–June 2018 and visit 2: February 2018–February 2020) and one assessment during COVID-19 (visit 3: July–December 2020). Surveys were administered to assess depressive symptoms, loneliness, and insomnia.

RESULTS
The study included 2829 adults (63.2% female, 60.6% White, mean [SD] age 75.6 [6.0] years). The prevalence of mild or greater depressive symptoms did not change significantly between the two pre-pandemic visits (P = 0.88) but increased significantly from pre- to during COVID-19 (19.3% at V2 to 30.4% at V3; P &lt; 0.001). Higher odds of mild or greater depressive symptoms at V3 were associated with being female (adjusted odds ratio [OR] 1.4 [95% CI 1.1–1.7]), identifying as non-Hispanic White (OR 1.4 [95% CI 1.1–1.7]), having obesity (OR 1.3 [95% CI 1.0–1.5]), and reporting mild or greater depressive symptoms at V1 (OR 4.0 [95% CI 2.9–5.4]), V2 (OR 4.4 [95% CI 3.2–5.9]), or both visits (OR 13.4 [95% CI 9.7–18.4]). The prevalence of loneliness increased from 12.3% at V1 to 22.1% at V3 (P &lt; 0.001), while the prevalence of insomnia remained stable across visits at 31.5–33.3%.

CONCLUSIONS
The prevalence of mild or greater depressive symptoms in older adults with diabetes was more than 1.6 times higher during COVID-19 than before the pandemic.
Pengaruh Konsumsi Energi dan Deforestasi Terhadap Output Nasional Lima Negara Anggota ASEAN
Authors: Kristiana Neni , Laut Lorentino Togar , Prakoso Jalu Aji 
Published: November 2021

The economic development aimed at improving people’s welfare often ignores the negative impact of the surrounding environment. The high use of energy aimed to increase the national income of the five ASEAN members hurts the environment by increasing CO2 levels in the air. This research aims to analyze the effect of CO2 emissions, coal consumption, electricity consumption and deforestation on national output in five ASEAN members. The variable used in this research is national output as the dependent variable and CO2 emissions, coal consumption, electricity consumption and deforestation as the independent variables. This research uses secondary data. The data is the panel data of five ASEAN members (Indonesia, Malaysia, Thailand, Philippines, Myanmar) from 2002 until 2018. The research method in this time is panel data regression, using Fixed Effect Model. This research shows that in five ASEAN members from 2002 until 2018, CO2 emissions harm national output, coal consumption, and electricity consumption positively affects national outcome, while deforestation does not affect national output.
Pengaruh Motivasi Belajar dan Persepsi Kemampuan Berpikir Kritis Terhadap Hasil Belajar
Authors: Fitri Selsa Della , S Armida 
Published: November 2021

This study aims to determine how the influence of learning motivation and the perception of critical thinking skills on economic learning outcomes in class X IPS SMA Adabiah 2 Padang. This type of research is a causal descriptive and associative research using SPSS version 26. The instruments used in this study were questionnaires and research documentation. The existing population of 102 students in sampling using proportional random sampling with a total of 82 students. The instrument trials used validity and reliability tests. Data analysis with descriptive and inductive analysis using the normality test, heterokedasticity test, multicollinearity test, multiple regression test and hypothesis test using the F test and t test. From the results of the study show: (1) Learning Motivation and Perception of Critical Thinking Ability together have a positive and significant influence on student economic learning outcomes seen from the value of sig. 0,000> 0.05. (2) There is a positive and significant influence of learning motivation on student economic learning outcomes seen from Sig. 0,000> 0.05. (3) There is no significant effect on the perception of critical thinking skills on economic learning outcomes seen from Sig. 0.946> 0.05. Keywords: learning motivation, perception of critical thinking ability, learning outcomes