bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation metrics of homogenization techniques on artificially inhomogenized monthly temperature networks in Sweden and Slovenia (1950–2005)
Authors: Coscarelli Roberto , Caroletti Giulio Nils , Joelsson Magnus , Engström Erik , Caloiero Tommaso 
Published: September 2021

AbstractIn order to correctly detect climate signals and discard possible instrumentation errors, establishing coherent data records has become increasingly relevant. However, since real measurements can be inhomogeneous, their use for assessing homogenization techniques is not directly possible, and the study of their performance must be done on homogeneous datasets subjected to controlled, artificial inhomogeneities. In this paper, considering two European temperature networks over the 1950–2005 period, up to 7 artificial breaks and an average of 107 missing data per station were introduced, in order to determine that mean square error, absolute bias and factor of exceedance can be meaningfully used to validate the best-performing homogenization technique. Three techniques were used, ACMANT and two versions of HOMER: the standard, automated setup mode and a manual setup. Results showed that the HOMER techniques performed better regarding the factor of exceedance, while ACMANT was best with regard to absolute error and root mean square error. Regardless of the technique used, it was also established that homogenization quality anti-correlated meaningfully to the number of breaks. On the other hand, as missing data are almost always replaced in the two HOMER techniques, only ACMANT performance is significantly, negatively affected by the amount of missing data.
Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
Authors: Li Jiahui , Pang Jinglong , Liu Zhe , Ge XianMing , Zhen Yanan , Jiang Chen Chen , Liu Yaming , Huo Qiang , Sun Yiming , Liu Hao 
Published: September 2021

AbstractShikonin is the main component of the traditional Chinese medicine comfrey, which can inhibit the activity of PKM2 by regulating glycolysis and ATP production. Rheumatoid arthritis synovial cells (RA-FLSs) have been reported to increase glycolytic activity and have other similar hallmarks of metabolic activity. In this study, we investigated the effects of shikonin on glycolysis, mitochondrial function, and cell death in RA-FLSs. The results showed that shikonin induced apoptosis and autophagy in RA-FLSs by activating the production of reactive oxygen species (ROS) and inhibiting intracellular ATP levels, glycolysis-related proteins, and the PI3K-AKT-mTOR signaling pathway. Shikonin can significantly reduce the expression of apoptosis-related proteins, paw swelling in rat arthritic tissues, and the levels of inflammatory factors in peripheral blood, such as TNF-α, IL-6, IL-8, IL-10, IL-17A, and IL-1β while showing less toxicity to the liver and kidney.
Human cortical dynamics during full-body heading changes
Authors: Gramann Klaus , Hohlefeld Friederike U. , Gehrke Lukas , Klug Marius 
Published: September 2021

AbstractThe retrosplenial complex (RSC) plays a crucial role in spatial orientation by computing heading direction and translating between distinct spatial reference frames based on multi-sensory information. While invasive studies allow investigating heading computation in moving animals, established non-invasive analyses of human brain dynamics are restricted to stationary setups. To investigate the role of the RSC in heading computation of actively moving humans, we used a Mobile Brain/Body Imaging approach synchronizing electroencephalography with motion capture and virtual reality. Data from physically rotating participants were contrasted with rotations based only on visual flow. During physical rotation, varying rotation velocities were accompanied by pronounced wide frequency band synchronization in RSC, the parietal and occipital cortices. In contrast, the visual flow rotation condition was associated with pronounced alpha band desynchronization, replicating previous findings in desktop navigation studies, and notably absent during physical rotation. These results suggest an involvement of the human RSC in heading computation based on visual, vestibular, and proprioceptive input and implicate revisiting traditional findings of alpha desynchronization in areas of the navigation network during spatial orientation in movement-restricted participants.
Laser isotope separation of 176Lu through off-the-shelf lasers
Authors: Suryanarayana M. V. , Sankari M. 
Published: September 2021

AbstractWe propose a novel and simple method for the laser isotope separation of 176Lu a precursor for the production of 177Lu medical isotope. The physics of the laser-atom interaction has been studied through the dynamics of the atomic level populations using the density matrix formalism. It has been shown that a combination of cw excitation lasers and pulsed ionization laser can be used for the laser isotope separation of 176Lu. The optimum conditions for the efficient and selective separation of 176Lu have been derived by studying the time evolution of level population under laser excitation. It has also been shown that, it might be possible to produce ~ 100% enriched 176Lu isotope at a rate of 5 mg/h, which is higher than all previously reported methods so far. The isotope separation process proposed can be easily adopted using off-the-shelf lasers, for similar atomic systems.
Neural underpinnings of morality judgment and moral aesthetic judgment
Authors: Cheng Qiuping , Wen Xue , Ye Guozhen , Liu Yanchi , Kong Yilong , Mo Lei 
Published: September 2021

AbstractMorality judgment usually refers to the evaluation of moral behavior`s ability to affect others` interests and welfare, while moral aesthetic judgment often implies the appraisal of moral behavior's capability to provide aesthetic pleasure. Both are based on the behavioral understanding. To our knowledge, no study has directly compared the brain activity of these two types of judgments. The present study recorded and analyzed brain activity involved in the morality and moral aesthetic judgments to reveal whether these two types of judgments differ in their neural underpinnings. Results reveled that morality judgment activated the frontal, parietal and occipital cortex previously reported for motor representations of behavior. Evaluation of goodness and badness showed similar patterns of activation in these brain regions. In contrast, moral aesthetic judgment elicited specific activations in the frontal, parietal and temporal cortex proved to be involved in the behavioral intentions and emotions. Evaluation of beauty and ugliness showed similar patterns of activation in these brain regions. Our findings indicate that morality judgment and moral aesthetic judgment recruit different cortical networks that might decode others' behaviors at different levels. These results contribute to further understanding of the essence of the relationship between morality judgment and aesthetic judgment.
A negative piezo-conductive effect from doped semiconducting polymer thin films
Authors: Yi Chao , Shen Lening , Zheng Jie , Gong Xiong 
Published: September 2021

AbstractIn the past years, piezo-conductive sensors have drawn great attention in both academic and industrial sectors. The piezo-conductive sensors made by inorganic semiconductors exhibited poor mechanical flexibility, restricting their further practical applications. In this study, we report the piezo-conductive sensors by a semiconducting polymer, poly(3,4-ethylenedioxythiophene) doped with tosylate ions (PEDOT:Tos) thin films. Systemically studies indicate that the piezo-conductive response of the PEDOT:Tos thin films is originated from the deformation of the PEDOT crystal cells and the stretched π–π distances induced by Tos. Moreover, the negative piezo-conductive effect, for the first time, is observed from PEDOT:Tos thin film under the pressure. A working mechanism is further proposed to interpret the transient from a positive to a negative piezo-conductive response within the PEDOT:Tos thin films. Our studies offer a facile route to approach effective piezo-conductive sensors based on conjugated polymers.
Designing multiepitope-based vaccine against Eimeria from immune mapped protein 1 (IMP-1) antigen using immunoinformatic approach
Authors: Madlala Thabile , Adeleke Victoria T. , Fatoba Abiodun J. , Okpeku Moses , Adeniyi Adebayo A. , Adeleke Matthew A. 
Published: September 2021

AbstractDrug resistance against coccidiosis has posed a significant threat to chicken welfare and productivity worldwide, putting daunting pressure on the poultry industry to reduce the use of chemoprophylactic drugs and live vaccines in poultry to treat intestinal diseases. Chicken coccidiosis, caused by an apicomplexan parasite of Eimeria spp., is a significant challenge worldwide. Due to the experience of economic loss in production and prevention of the disease, development of cost-effective vaccines or drugs that can stimulate defence against multiple Eimeria species is imperative to control coccidiosis. This study explored Eimeria immune mapped protein-1 (IMP-1) to develop a multiepitope-based vaccine against coccidiosis by identifying antigenic T-cell and B-cell epitope candidates through immunoinformatic techniques. This resulted in the design of 7 CD8+, 21 CD4+ T-cell epitopes and 6 B-cell epitopes, connected using AAY, GPGPG and KK linkers to form a vaccine construct. A Cholera Toxin B (CTB) adjuvant was attached to the N-terminal of the multiepitope construct to improve the immunogenicity of the vaccine. The designed vaccine was assessed for immunogenicity (8.59968), allergenicity and physiochemical parameters, which revealed the construct molecular weight of 73.25 kDa, theoretical pI of 8.23 and instability index of 33.40. Molecular docking simulation of vaccine with TLR-5 with binding affinity of − 151.893 kcal/mol revealed good structural interaction and stability of protein structure of vaccine construct. The designed vaccine predicts the induction of immunity and boosted host's immune system through production of antibodies and cytokines, vital in hindering surface entry of parasites into host. This is a very important step in vaccine development though further experimental study is still required to validate these results.
The use of multi-criteria method in the process of threat assessment to the environment
Authors: Zajusz-Zubek Elwira , Korban Zygmunt 
Published: September 2021

AbstractMeasurements of the content of trace elements, including toxic and carcinogenic metals, in various fractions of particulate matter PM are an important element of environmental monitoring and research involving their impact on human health. The article presents the measurement results of atmospheric composition of suspended dust (PM10), respirable fraction (PM2.5) and submicron particulate matter (PM1) collected with the Dekati PM10 cascade impactor. Samples were collected in the vicinity of four working power plants (from 28 May to 23 September 2014) and four coking plants (from 4 May to 28 August 2015) in Upper Silesia, Poland. The qualitative and quantitative analysis of the solutions: arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), antimony (Sb) and selenium (Se) obtained for individual fractions was performed by inductively coupled plasma mass spectrometry, using the apparatus ICP-MS. The research results were used to determine a synthetic assessment of the threat to the anthropogenic environment and for the preparation of the ranking of the measured points.
Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli
Authors: Wang Miaomiao , Chan Edward Wai Chi , Wan Yingkun , Wong Marcus Ho-yin , Chen Sheng 
Published: September 2021

AbstractRecent evidence suggests that metabolic shutdown alone does not fully explain how bacteria exhibit phenotypic antibiotic tolerance. In an attempt to investigate the range of starvation-induced physiological responses underlying tolerance development, we found that active maintenance of the transmembrane proton motive force (PMF) is essential for prolonged expression of antibiotic tolerance in bacteria. Eradication of tolerant sub-population could be achieved by disruption of PMF using the ionophore CCCP, or through suppression of PMF maintenance mechanisms by simultaneous inhibition of the phage shock protein (Psp) response and electron transport chain (ETC) complex activities. We consider disruption of bacterial PMF a feasible strategy for treatment of chronic and recurrent bacterial infections.
Detection of Campylobacter jejuni and Salmonella typhimurium in chicken using PCR for virulence factor hipO and invA genes (Saudi Arabia)
Authors: Alarjani Khaloud M. , Elkhadragy Manal F. , Al-Masoud Abdulrahman H. , Yehia Hany M. 
Published: September 2021

Abstract
Campylobacter jejuni and Salmonella typhimurium are the leading causes of bacterial food contamination in chicken carcasses. Contamination is particularly associated with the slaughtering process. The present study isolated C. jejuni and S. typhimurim from fifty chicken carcass samples, all of which were acquired from different companies in Riyadh, Saudi Arabia. The identification of C. jejuni was performed phenotypically by using a hippurate test and genetically using a polymerase chain reaction with primers for 16S rRNA and hippurate hydrolase (hipO gene). For the dentification of S. typhimurim, a serological Widal test was carried out using serum anti-S. typhimurium antibodies. Strains were genetically detected using invA gene primers. The positive isolates for C. jejuni showed a specific molecular size of 1448 bp for 16S rRNA and 1148 bp for hipO genes. However, the positive isolates of the invA gene exhibited a specific molecular size at 244 bp using polymerase chain reaction (PCR). Comparing sequencing was performed with respect to the invA gene and the BLAST nucleotide isolates that were identified as Salmonella enterica subsp. enterica serovar typhimurium strain ST45, thereby producing a similarity of 100%. The testing identified C.jejuni for hippuricase, GenBank: Z36940.1. While many isolates of Salmonella spp. that contained the invA gene were not necessarily identified as S. typhimurim, the limiting factor for the Widal test used antiS. typhimurum antibodies. The multidrug resistance (MDR) of C. jejuni isolates in chickens was compared with the standard C. jejuni strain ATCC 22931. Similarly, S. typhimurium isolates were compared with the standard S. typhimurium strain ATCC 14028.
English BESA Morphosyntax Performance Among Spanish–English Bilinguals Who Use African American English
Authors: Gatlin-Nash Brandy , Peña Elizabeth D. , Bedore Lisa M. , Simon-Cereijido Gabriela , Iglesias Aquiles 
Published: September 2021

Purpose
This study examined the use of African American English (AAE) among a group of young Latinx bilingual children and the accuracy of the English Morphosyntax subtest of the Bilingual English–Spanish Assessment (BESA) in classifying these children with and without developmental language disorder (DLD).

Method

Children (
N
= 81) between the ages of 4;0 and 7;1 (years;months) completed a narrative task and the BESA Morphosyntax subtest. We identified DLD based on four reference measures. We compared specific dialectal features used by children with DLD and their typically developing peers. We also conducted an overall analysis of the BESA subtest and subsequent item-level analyses to determine if particular items were more likely to contribute to the correct classification of the participants.

Results
Children with DLD used three AAE forms in their narrative samples (subject–verb agreement, zero copula/auxiliary, or zero past tense) more frequently than their typically developing peers. Area-under-the-curve estimates for the cloze, sentence repetition, and composite scores of the BESA indicated that the assessment identified children with DLD in the sample with good sensitivity. Item analysis indicated that the majority of items (84%) significantly differentiated typically developing children and children with DLD.

Conclusions
The BESA English Morphosyntax subtest appears to be a valid tool for the identification of DLD in children exposed to AAE and Spanish. We provide practical implications and suggestions for future research addressing the identification of DLD among children from culturally and linguistically diverse backgrounds.
PE‐EDD: An efficient peer‐effect‐based financial fraud detection approach in publicly traded China firms
Authors: Xia Hui , Ma Hui , Cheng Ping 
Published: September 2021

AbstractFinancial fraud arises from the exaggeration of business interests, and an accurate detection or prediction is a useful tool for both corporate management and capital market systems. A collection of computer technologies has been made on this problem so far, and one of the most important solutions is unsupervised learning algorithms. Among them, most approaches work by analysing the internal relations in financial data and finding a new description of non‐fraud firms. However, current studies focus a lot on the geometry attribute of financial data, while overlooking the obvious behaviour patterns and peer effects among firms. This has limited the accuracy of representation and furthermore the detection performance. In this work, a very general class of functions is allowed to represent firms, constraining them by peer effects between firms and presenting an error‐distribution‐based financial fraud firm detection approach. Experimental results have shown great performance of the proposed approach.
Relaying protocol design and optimization for energy harvesting relaying in SWIPT networks
Authors: Hu Yifan , Cao Ning , Chen Yunfei 
Published: September 2021

AbstractIn this article, a relaying network with simultaneous wireless information and power transfer (SWIPT) is considered, where the relaying nodes are energy‐constrained. The relaying nodes rely on energy harvesting (EH) technique for energy supply and they use different directive transmitters for information transmission and energy transfer, respectively, to enhance the SWIPT relaying performance. A novel discrete‐time‐switch and power‐split (DTS‐PS) based energy harvesting mixture transmission (EH‐MT) protocol for each EH decode and forwarding (DF) relaying node is proposed. The expressions for the average information rate and the energy transfer power are derived analytically and verified by simulations. An optimization function is formulated, and the optimal parameters are obtained analytically and verified by simulation.
A CMRR enhancement circuit by employing auxiliary buffer of capacitively coupled instrumentation amplifier for neural signal recording
Authors: Zhu Longbin , Zhou Zhijun , Zhang Chiyuan , Meng Qiao , Wang Zhi‐gong 
Published: September 2021

AbstractHere, a common‐mode rejection ratio (CMRR) enhancement circuit is proposed by employing an auxiliary buffer (AB) to the pseudo resistors of the capacitively coupled instrumentation amplifier (CCIA). After applying AB to CCIA, the differential‐mode gain remains the same with an extended bandwidth, and the common‐mode gain is reduced, and therefore, the CMRR is enhanced.
Identification of point sources in gamma rays using U-shaped convolutional neural networks and a data challenge
Authors: Panes Boris , Eckner Christopher , Hendriks Luc , Caron Sacha , Dijkstra Klaas , Jóhannesson Guðlaugur , de Austri Roberto Ruiz , Zaharijas Gabrijela 
Published: September 2021

Context. At GeV energies, the sky is dominated by the interstellar emission from the Galaxy. With limited statistics and spatial resolution, accurately separating point sources is therefore challenging.
Aims. Here we present the first application of deep learning based algorithms to automatically detect and classify point sources from gamma-ray data. For concreteness we refer to this approach as AutoSourceID.
Methods. To detect point sources, we utilized U-shaped convolutional networks for image segmentation and k-means for source clustering and localization. We also explored the Centroid-Net algorithm, which is designed to find and count objects. Using two algorithms allows for a cross check of the results, while a combination of their results can be used to improve performance. The training data are based on 9.5 years of exposure from The Fermi Large Area Telescope (Fermi-LAT) and we used source properties of active galactic nuclei (AGNs) and pulsars (PSRs) from the fourth Fermi-LAT source catalog in addition to several models of background interstellar emission. The results of the localization algorithm are fed into a classification neural network that is trained to separate the three general source classes (AGNs, PSRs, and FAKE sources).
Results. We compared our localization algorithms qualitatively with traditional methods and find them to have similar detection thresholds. We also demonstrate the robustness of our source localization algorithms to modifications in the interstellar emission models, which presents a clear advantage over traditional methods. The classification network is able to discriminate between the three classes with typical accuracy of ∼70%, as long as balanced data sets are used in classification training. We published online our training data sets and analysis scripts and invite the community to join the data challenge aimed to improve the localization and classification of gamma-ray point sources.
Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats
Authors: Li Dan , Lyu Yuanfeng , Zhao Jiajia , Ji Xiaoyu , Zhang Yufeng , Zuo Zhong 
Published: September 2021

AbstractAlthough Polygoni Multiflori Radix (PMR) has been widely used as a tonic and an anti-aging remedy for centuries, the extensively reported hepatotoxicity and potential kidney toxicity hindered its safe use in clinical practice. To better understand its toxicokinetics, the current study was proposed, aiming to evaluate the biodistributions of the major PMR components including 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside (TSG), emodin, emodin-8-O-β-D-glucopyranoside (EMG) and physcion as well as their corresponding glucuronides following bolus and multiple oral administrations of PMR to rats. Male Sprague-Dawley rats received a bolus dose or 21 days of oral administrations of PMR concentrated granules at 4.12 g/kg (equivalent to 20.6 g/kg raw material). Fifteen minutes after bolus dose or the last dose on day 21, rats were sacrificed and the blood, liver, and kidney were collected for the concentration determination of both parent form
and glucuronides of TSG, emodin, EMG, and physcion by HPLC-MS/MS. Among all the tested analytes, TSG, EMG, EMG glucuronides in liver and TSG, EMG, as well as all the glucuronides of these analytes in the kidney demonstrated the most significant accumulation after multiple doses. Moreover, the levels of the parent analytes were all significantly higher in liver and kidney in comparison to their plasma levels. Strong tissue binding of all four analytes and accumulation of TSG, EMG, and EMG glucuronides in the liver and TSG, EMG, as well as the glucuronides of all four analytes in the kidney after multiple dosing of PMR were considered to be associated with its toxicity.