bluuebunny/crossref_metadata_2025_split huggingface dataset:
The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation
Authors: Recalde Miriam , Gárate-Rascón María , Elizalde María , Azkona María , Latasa M Ujue , Bárcena-Varela Marina , Sangro Bruno , Fernández-Barrena Maite G , Ávila Matías A , Arechederra María , Berasain Carmen 
Published: July 2021

Abstract
Gene expression is finely and dynamically controlled through the tightly coordinated and interconnected activity of epigenetic modulators, transcription and splicing factors and post-translational modifiers. We have recently identified the splicing factor SLU7 as essential for maintaining liver cell identity and genome integrity and for securing cell division both trough transcriptional and splicing mechanisms. Now we uncover a new function of SLU7 controlling gene expression at the epigenetic level. We show that SLU7 is required to secure DNMT1 protein stability and a correct DNA methylation. We demonstrate that SLU7 is part in the chromatome of the protein complex implicated in DNA methylation maintenance interacting with and controlling the integrity of DNMT1, its adaptor protein UHRF1 and the histone methyl-transferase G9a at the chromatin level. Mechanistically, we found that SLU7 assures DNMT1 stability preventing its acetylation and degradation by facilitating its interaction with HDAC1 and the desubiquitinase USP7. Importantly, we demonstrate that this DNMT1 dependency on SLU7 occurs in a large panel of proliferating cell lines of different origins and in in vivo models of liver proliferation. Overall, our results uncover a novel and non-redundant role of SLU7 in DNA methylation and present SLU7 as a holistic regulator of gene expression.
eIF4G is retained on ribosomes elongating and terminating on short upstream ORFs to control reinitiation in yeast
Authors: Mohammad Mahabub Pasha , Smirnova Anna , Gunišová Stanislava , Valášek Leoš Shivaya 
Published: July 2021

Abstract
Translation reinitiation is a gene-specific translational control mechanism. It is characterized by the ability of short upstream ORFs to prevent full ribosomal recycling and allow the post-termination 40S subunit to resume traversing downstream for the next initiation event. It is well known that variable transcript-specific features of various uORFs and their prospective interactions with initiation factors lend them an unequivocal regulatory potential. Here, we investigated the proposed role of the major initiation scaffold protein eIF4G in reinitiation and its prospective interactions with uORF’s cis-acting features in yeast. In analogy to the eIF3 complex, we found that eIF4G and eIF4A but not eIF4E (all constituting the eIF4F complex) are preferentially retained on ribosomes elongating and terminating on reinitiation-permissive uORFs. The loss of the eIF4G contact with eIF4A specifically increased this retention and, as a result, increased the efficiency of reinitiation on downstream initiation codons. Combining the eIF4A-binding mutation with that affecting the integrity of the eIF4G1–RNA2-binding domain eliminated this specificity and produced epistatic interaction with a mutation in one specific cis-acting feature. We conclude that similar to humans, eIF4G is retained on ribosomes elongating uORFs to control reinitiation also in yeast.
Reliability and validity of a novel cognitive self-assessment tool for patients with cancer
Authors: Zarrella Giuliana V , Perez Alice , Dietrich Jorg , Parsons Michael W 
Published: July 2021

Abstract

Background
Subjective cognitive function is an important outcome measure in oncology. The Functional Assessment of Cancer Therapy—Brain (FACT-Br) is a quality of life (QoL) measure that includes indices of physical, emotional, social, and neurologic aspects of disease but does not measure cognitive function. This study seeks to validate a novel index of cognition derived from the FACT-Br.

Methods
Patients with heterogeneous cancer diagnoses (N = 214) completed neuropsychological evaluation and self-report measures. Nine FACT-Br items regarding cognition were combined to form the FACT-Br-cognitive index (CI). Reliability was evaluated by exploratory factor analysis and internal consistency. Concurrent validity was assessed by correlating FACT-Br-CI with the Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive-8 scales. Discriminant validity was assessed by correlating FACT-Br-CI with other FACT-Br indices and the Beck Depression and Anxiety Inventories (BDI, BAI). Exploratory analyses evaluated the impact of cognitive performance and disease variables on FACT-Br-CI.

Results
The FACT-Br-CI consisted of a single factor that demonstrated high internal consistency (α = 0.867) and strong concurrent validity, correlating strongly with PROMIS Cognitive-8 scales (r = 0.675-0.782). The relationship between the FACT-Br-CI and other FACT subscales ranged from moderate to strong (r = 0.372-0.601), as did correlations with measures of depression (BDI, r = −0.621) and anxiety (BAI, r = −0.450). Modest correlations were observed with neuropsychological measures (rs = 0.249-0.300).

Conclusions
The FACT-Br-CI is a reliable and valid measure of self-reported cognition. Studies that included the FACT-Br could be retrospectively analyzed to assess subjective cognitive outcomes, enriching the information from prior research. Integration of the FACT-Br-CI in routine clinical care may be an efficient method of monitoring cognition.
Occupational burnout among clinical research associates in China
Authors: Fu Z , Yuan Y , Jiang M 
Published: July 2021

AbstractBackgroundClinical research associates (CRAs) play an important role in pharmaceutical research and development. Despite growing concern about occupational burnout among CRAs in China, little is known about this topic.AimsWe evaluated the factors associated with occupational burnout among CRAs in China and assessed the extent and nature of this syndrome in order to develop effective countermeasures.MethodsIn October 2020, we collected data from a convenience sample of 438 CRAs from 26 major cities across China using a custom-designed questionnaire. We evaluated their psychopathological status and degree of occupational burnout based on the Maslach Burnout Inventory. Factors associated with burnout were identified using the Wilcoxon rank test, Kruskal–Wallis test, Spearman’s rank correlation and multivariable ordinal logistic regression.ResultsOf the 438 CRAs analyzed, 82% showed signs of occupational burnout, with a large proportion experiencing moderate burnout (50%). Burnout in Chinese CRAs manifested as emotional exhaustion (77%), depersonalization (66%) and low sense of accomplishment (15%). The severity of burnout was significantly affected by mode of working (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.04–2.34), average number of working hours per week (OR 1.68, 95% CI 1.14–2.46), support provided by the hospital (OR 3.13, 95% CI 1.40–6.99) and likelihood of receiving a promotion (OR 4.05, 95% CI 1.34–12.22) (all P &lt; 0.05).ConclusionsThe incidence of occupational burnout among CRAs in China is high. Companies and hospitals must take effective measures to establish support systems for CRAs in order to alleviate this situation and thereby ensure the quality of clinical trials.
To Die Is Gain
Authors: Schellenberg Ryan S. 
Published: July 2021

AbstractThis chapter locates incarceration within a broader economy of violence in the Roman world. Prison was legible, it argues, in relation to embodied scripts of honor and shame, self-mastery and slavishness, and what might be called the somatic grammar of subjugation. Among the elite, who were accustomed to bodily inviolability, imprisonment breached a key symbolic boundary that distinguished persons of honor from those subject to them. For Paul, however, as for others among the non-elite, prison was an acute instance of an all too familiar reality—namely, subjection to the mastery of more powerful men. Paul’s desire to die and be with Christ (Phil 1:23) must therefore be read alongside his vision of glorious somatic transformation, a transformation that is also and not incidentally an inversion of power relations, with Paul now sharing the sovereign glory of Christ, before whom all knees must finally bow.
Nonprofit Marketing
Authors: Landreth Grau Stacy 
Published: July 2021

Abstract
Chapter 1 introduces the concept of marketing and discusses the differences between marketing and nonprofit marketing, namely the issues around target audiences and the differences between the users of nonprofit services and the funding mechanisms that help them stay in business. This chapter discusses the reasons that nonprofit organization leaders have resisted marketing in the past and why it is important to embrace marketing today. It includes an overview of “philanthropy by the numbers” and examines some of the trends that are affecting nonprofit organizations. Finally, the first chapter provides a roadmap for the rest of the book.
Understanding and Engaging with Your Stakeholders
Authors: Landreth Grau Stacy 
Published: July 2021

Abstract
Chapter 4 covers the idea of target audiences for nonprofit organizations. This is one area where marketing for nonprofit organizations differs from that of other organizations, namely because the recipient of services don’t necessarily pay for these services. Instead the money for nonprofits typically comes from donors or other sources of funding. That said, it is important to understand each stakeholder and how to craft effective messages to reach them. Additionally, there are other stakeholders to consider. This chapter also discussed the core tenets of STP—segmentation, targeting, and positioning of audiences for nonprofit organizations. It includes several tools that are helpful for the STP process.
Marketing Communication Measurement and Evaluation
Authors: Landreth Grau Stacy 
Published: July 2021

Abstract
Chapter 8 picks up from Chapter 7 and discusses the importance of measurement and evaluation, particulary of marketing communications. Importantly, this chapter is not about program evaluation, but rather is concentrated on communication efforts. The chapter includes the differences and linkages among concepts such as goals, objectives, and metrics (and how these link back to strategy). The chapter goes into depth with metrics for measuring paid, owned, and earned media. This chapter underscores the importance of measuring (and research) to gain insights that allow for a more effective organizational presence.
Placeholders
Authors: Nathan Marco J. 
Published: July 2021

Abstract
Black boxes are placeholders. What is a placeholder? What role do they play in science? These questions are addressed via a discussion of biological fitness. Fitness is the propensity of an organism or a trait to survive and reproduce. In addition, fitness is a placeholder for a deeper account that dispenses with the concept of fitness altogether. These two theses are in tension. Qua placeholder, fitness is explanatory. Qua disposition, it explicates but cannot explain the associated behavior. The solution involves drawing a distinction between two kinds of placeholders. First, a placeholder may stand in for the range of events to be accounted for. In this case, the placeholder functions as a frame. It spells out a range of behaviors in need of explanation. Second, a placeholder may stand in for mechanisms which bring about the behavior specified by the frame. When this occurs, the placeholder becomes an explanans and one can refer to it as a difference-maker.
Diet Mechanistic Philosophy
Authors: Nathan Marco J. 
Published: July 2021

Abstract
This chapter compares and contrasts the black-boxing approach with the “new wave of mechanistic philosophy.” Is the present treatment of black boxes novel and original? Or is it a rehashing of ideas that have been on the table since the turn of the new millennium? The black-boxing recipe fits in quite well with the depiction of science being in the business of discovering and modeling mechanisms. All three steps underlying the construction of a black box have been stressed, in some form or degree, in the extant literature. Nevertheless, the construction of black boxes, as presented here, dampens many of the ontological implications that characterize the contemporary landscape. This allows one to respond to some objections raised against the traditional mechanism. For this reason, the author provocatively refers to black-boxing as a “diet” mechanistic philosophy, with all the epistemic flavor of the old-fashioned mechanistic view, but hardly any metaphysical calories.
How to Know Everything, Oren Izenberg
Authors: Izenberg Oren 
Published: July 2021

AbstractPoetry’s critics and defenders have tended to agree that whatever the achievements of the art may be, knowledge (in the “ordinary” philosophical sense) is not among them. This chapter mounts a defense of the epistemic ambitions of Emily Dickinson’s poetry. It offers an extended comparison between Dickinson’s poetry and the “Cosmoscope,” the imaginary tool offered in David Chalmers’s Constructing the World. The Cosmoscope allows Chalmers to consider what basic truths would be required to make an entire universe of truths accessible to reason. By highlighting the parallels between Chalmers’s basic classes of truth and Dickinson’s recurrent poetic emphases on descriptive precision, phenomenological sensitivity, formal indexicality, and thematic totality, the chapter aims to show that Dickinson understands her poems as assays in knowledge seeking within a knowable world—and to suggest that we should evaluate them accordingly.
Vocational Education and Youth Labor Market Integration
Authors: Muja Ardita , Gesthuizen Maurice , Wolbers Maarten H. J. 
Published: July 2021

Abstract
The transition from school to work is a crucial change young people experience during emerging adulthood, as the first steps taken into the labor market can influence future labor market careers and life prospects. One of the key responsibilities of education is to prepare students for the labor market, in which the vocational specificity of education systems is regarded as the central component in youth’s preparation for and allocation to the labor market. Despite many empirical studies examining the underlying mechanisms of the vocational impact of education on youth labor market integration, a review on this vast literature is lacking. Hence, in this chapter the authors provide a literature review on the role of vocational specificity in youth labor market integration, which operates through the individual level, study program level, and education system level. Moreover, a coherent system of indicators that measure vocational specificity at the three levels is provided.
Gateways to Occupational Success
Authors: Parker Philip D. , Bodkin-Andrews Gawaian , Trudgett Michelle , Walter Maggie 
Published: July 2021

Abstract
Education is a gateway to occupational success for emerging adults. Differences in access and uptake in higher education are thus a primary explanation for social stratification. In this chapter, the authors consider what might explain the Indigenous gap in educational attainment. Using multiple cohorts of the Longitudinal Study of Australian Youth, they show that the typical processes of educational mobility are similar across Indigenous and non-Indigenous emerging adults and have remained fairly constant in recent decades. Rather, educational inequality appears to result from lower attainment in both Indigenous parents and their children. Pursuing this lower level of attainment, the authors show that standard Western models of educational attainment fail to fully explain Indigenous educational inequality. They suggest a need to consider the unique knowledges and experiences of Indigenous people. They also argue that research needs to pay greater attention to the intersection between Indigenous status and other minority or marginalized statuses.
Introduction
Authors: Minow Martha 
Published: July 2021

Abstract
As traditional for-profit news media in the United States decline in economic viability and sheer numbers of outlets and staff, what does and what should the constitutional guarantee of freedom of the press mean? The book examines the current news ecosystem in the United States and chronicles historical developments in government involvement in shaping the industry. It argues that initiatives by the government and by private sector actors are not only permitted but called for as transformations in technology, economics, and communications jeopardize the production and distribution of and trust in news and the very existence of local news reporting. It presents twelve proposals for change to help preserve the free press essential to our democratic society.
Does the First Amendment Forbid, Permit, or Require Government Support of News Industries?
Authors: Minow Martha 
Published: July 2021

Abstract
Chapter 3 explores the First Amendment implications of government support of the news industry. It challenges the assumption that the Constitution bars any governmental role in the news media by analyzing First Amendment decisions by courts and legislatures, including historical shifts in First Amendment interpretations. The analysis identifies a range of constitutionally permissible tools for government actions to strengthen or save news industries and advances a positive conception of First Amendment rights that both sanctions and motivates new approaches to sustain the free press. First Amendment values strongly support government action to protect the generation, production, and distribution of news.
Coda
Authors: Minow Martha 
Published: July 2021

Abstract
Chapter 5 concludes with a call to action to fix the crisis in the news media. The First Amendment’s guarantee of free speech and free press presupposes the existence of an independent press. That predicate is now in jeopardy. Changes in the news industry threaten the project of democracy and obligate the government to act. The First Amendment is not a barrier but instead a basis for such action.
Synthesizing Imaginations
Authors: Rosenblatt Jason P. 
Published: July 2021

Abstract
Milton’s engagement with Selden’s natural law theory is a factor in the transformation that occurs between his earlier anti-prelatical tracts and the later treatises on divorce, freedom of the press, and the citizens’ right to depose any ruler. In his poetry, despite his Christian doctrinal preference, Milton’s non-hierarchical aesthetic attests to the amplitude of his vision. This derives in part from his exposure to Selden’s method of giving a fair hearing to all his pagan, Christian, Jewish, and Muslim sources. But the same passage in the Areopagitica that demonstrates Selden’s influence becomes, in the latter part of the chapter, a point of entry into the different ways that a scholar and a poet-polemicist view the same object. Selden recognizes the importance of mediated experience, whether scientifically, through a telescope, or religiously, through tradition. Milton distrusts “the glass of Galileo, less assured,” and believes only in sola scriptura and immediate experience.
Selden and Milton on the Bible
Authors: Rosenblatt Jason P. 
Published: July 2021

Abstract
The Bible provides the scope for Selden and Milton to display their brilliance: one as a great scholar boldly following his vision of the truth wherever it leads, the other as a creative genius finally overcoming his strong precursor, the King James Bible, to become the supreme poet of the hexaëmeron. Selden focuses his biblical Hebraic and post-biblical rabbinic scholarship on New Testament passages, offering immensely learned and sometimes startlingly original readings of the Apostolic Decree (Acts 15:20, 29; and 21:25) and four events in the life of Jesus: his rebuke of the Jews regarding korban (Mark 7:9–12); his pronouncement that “the truth shall make you free” (John 8:31–2; his driving the money-changers from the temple (John 2:13–17); and his trial (Matt. 26:63–6). If God is Milton’s father, and his scriptural word is the strongest of all precursor texts, then the King James Bible is the most intimidating version of that text. Milton’s marginal Hebrew substitutions for the KJB Psalm translations (1648) reveal anxiety and defensiveness. But the creation account in book 7 of Paradise Lost compresses the verses of Genesis 1, reducing them to their constituent elements and then outdoing them with the energy and magnificence of his interlinear poetic commentary. The poet’s anxiety-free transcendence of the KJB in book 7 can be seen as part of a general sense of joyous creativity.
Selden and Milton on Family Law
Authors: Rosenblatt Jason P. 
Published: July 2021

Abstract
This chapter discusses the relationship between Selden and Milton on family law. Like that of the first family in paradise, it may be mutual, although not equal. Milton drew on Selden’s scholarship for his ideas about concubinage, polygamy, the church’s meddling in marriage, and especially divorce. But Selden’s ownership of two Miltonic treatises on divorce, Tetrachordon and Colasterion (1645), both of them presumably acquired while he was writing Uxor Ebraica (1646), complicates the question of influence and suggests a possible reverse motion of spirit. The chapter begins by describing some of the differences between Selden’s two discussions of family law, both cited by Milton, the primordial, universal, natural law in De Jure Naturali et Gentium and the civil law of the Jews in Uxor Ebraica. Various hints—seedlings—in Milton’s Tetrachordon might have germinated in Selden’s mind to become the majestic flowering plant that occupies the four full chapters (3.20–3) of Uxor Ebraica devoted to the key phrases on divorce in Deuteronomy 24:1 and Matthew 5:32. Milton expanded the meaning of the Bible’s word fornication to include non-sexual sins or defects. Selden, relying mainly on the Talmud, would have retrojected Miltonic ideas into the debate over divorce that he established as occurring in the first century bce.
Making Law and Recording It: Part II
Authors: Rosenblatt Jason P. 
Published: July 2021

Abstract
John Selden’s historico-philological approach tends to prove that religious authority has its origins in civil institutions and their legal procedures, and to that extent his “literary” (philological) encounter with ancient texts helps determine the nature of law. Selden was an active member of the Long Parliament, chairing or serving on many committees, but there are very few transcripts of his speeches and none of his debates on the floor of the House of Commons. His only surviving debates from that decade took place in the Westminster Assembly of Divines, to which he was appointed by Parliament as a lay member. That makes them especially valuable. Even so, many of the transcripts are so lacunose that they are indecipherable as they appear in those volumes. This chapter is devoted to filling in the gaps and making the speeches coherent by finding their contexts in Selden’s scholarly works.