bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease
Authors: Rufaihah Abdul Jalil , Chen Ching Kit , Yap Choon Hwai , Mattar Citra N. Z. 
Published: March 2021

ABSTRACT
Birth defects contribute to ∼0.3% of global infant mortality in the first month of life, and congenital heart disease (CHD) is the most common birth defect among newborns worldwide. Despite the significant impact on human health, most treatments available for this heterogenous group of disorders are palliative at best. For this reason, the complex process of cardiogenesis, governed by multiple interlinked and dose-dependent pathways, is well investigated. Tissue, animal and, more recently, computerized models of the developing heart have facilitated important discoveries that are helping us to understand the genetic, epigenetic and mechanobiological contributors to CHD aetiology. In this Review, we discuss the strengths and limitations of different models of normal and abnormal cardiogenesis, ranging from single-cell systems and 3D cardiac organoids, to small and large animals and organ-level computational models. These investigative tools have revealed a diversity of pathogenic mechanisms that contribute to CHD, including genetic pathways, epigenetic regulators and shear wall stresses, paving the way for new strategies for screening and non-surgical treatment of CHD. As we discuss in this Review, one of the most-valuable advances in recent years has been the creation of highly personalized platforms with which to study individual diseases in clinically relevant settings.
Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver
Authors: Ko Masayoshi , Kamimura Kenya , Owaki Takashi , Nagoya Takuro , Sakai Norihiro , Nagayama Itsuo , Niwa Yusuke , Shibata Osamu , Oda Chiyumi , Morita Shinichi , Kimura Atsushi , Inoue Ryosuke , Setsu Toru , Sakamaki Akira , Yokoo Takeshi , Terai Shuji 
Published: March 2021

ABSTRACT
The etiology of non-alcoholic fatty liver disease (NAFLD) consists of various factors, including neural signal pathways. However, the molecular mechanisms of the autonomic neural signals influencing NAFLD progression have not been elucidated. Therefore, we examined the involvement of the gut-liver neural axis in NAFLD development and tested the therapeutic effect of modulation of this axis in this study. To test the contribution of the gut-liver neural axis, we examined NAFLD progression with respect to body weight, hepatic steatosis, fibrosis, intestinal tight junction, microbiota and short-chain fatty acids in NAFLD models of choline-deficient defined L-amino-acid and high-fat diet-fed mice with or without blockades of autonomic nerves from the liver. Blockade of the neural signal from the liver to the gut in these NAFLD mice models ameliorated the progression of liver weight, hepatic steatosis and fibrosis by modulating serotonin expression in the small intestine. It was related to the severity of the liver pathology, the tight junction protein expression, microbiota diversity and short-chain fatty acids. These effects were reproduced by administrating serotonin antagonist, which ameliorated the NAFLD progression in the NAFLD mice models. Our study demonstrated that the gut-liver neural axis is involved in the etiologies of NAFLD progression and that serotonin expression through this signaling network is the key factor of this axis. Therefore, modulation of the gut-liver neural axis and serotonin antagonist ameliorates fatty and fibrotic changes in non-alcoholic fatty liver, and can be a potential therapeutic target of NAFLD.
This article has an associated First Person interview with the first author of the paper.
Epigenetic potential affects immune gene expression in house sparrows
Authors: Hanson Haley E. , Zimmer Cedric , Koussayer Bilal , Schrey Aaron W. , Maddox J. Dylan , Martin Lynn B. 
Published: March 2021

ABSTRACT
Epigenetic mechanisms may play a central role in mediating phenotypic plasticity, especially during range expansions, when populations face a suite of novel environmental conditions. Individuals may differ in their epigenetic potential (EP; their capacity for epigenetic modifications of gene expression), which may affect their ability to colonize new areas. One form of EP, the number of CpG sites, is higher in introduced house sparrows (Passer domesticus) than in native birds in the promoter region of a microbial surveillance gene, Toll-like Receptor 4 (TLR4), which may allow invading birds to fine-tune their immune responses to unfamiliar parasites. Here, we compared TLR4 gene expression from whole blood, liver and spleen in house sparrows with different EP, first challenging some birds with lipopolysaccharide (LPS), to increase gene expression by simulating a natural infection. We expected that high EP would predict high inducibility and reversibility of TLR4 expression in the blood of birds treated with LPS, but we did not make directional predictions regarding organs, as we could not repeatedly sample these tissues. We found that EP was predictive of TLR4 expression in all tissues. Birds with high EP expressed more TLR4 in the blood than individuals with low EP, regardless of treatment with LPS. Only females with high EP exhibited reversibility in gene expression. Further, the effect of EP varied between sexes and among tissues. Together, these data support EP as one regulator of TLR4 expression.
Krypta unter der Vierung des Basler Münsters: Eine neue Informationsstelle
Authors: Bernasconi Marco , Hagendorn Andrea , Lassau Guido , Von Harten Beate 
Published: March 2021

Zum 1000-jährigen Jubiläum des Heinrichsmünsters hat die Archäologische Bodenforschung im Mai 2019 in der bisher unzugänglichen Krypta unter der Vierung die Archäologische Informationsstelle «Basel, 820–1500 n. Chr. – Krypta unter der Vierung des Münsters» eröffnet. Sie ist seither die Hauptattraktion des Rundgangs zu Originalfundplätzen der keltischen, römischen und mittelalterlichen Stadtgeschichte, zu denen u. a. auch mittels GPS eine dreisprachige App führt.
Die Krypta unter der Vierung war im 19. Jahrhundert während Umbaumassnahmen zugunsten einer grosszügigeren Nutzung des Mittelschiffs für Gottesdienste und Konzerte abgebrochen und zugeschüttet worden. Erst 1966 wurde sie bei archäologischen Ausgrabungen wieder freigelegt und mit einer Betondecke versehen. Der Raum blieb danach über 50 Jahre lang unberührt. Er ist der einzige Ort im Münster, an dem Baureste aller Vorgängerbauten zu sehen sind.
A Syntactical Analysis of Lewis’s Triviality Result
Authors: Pizzi Claudio E. A. 
Published: March 2021

The first part of the paper contains a probabilistic axiomatic extension of the conditional system WV, here named WVPr. This system is extended with the axiom (Pr4): PrA = 1 ⊃ □A. The resulting system, named WVPr∗, is proved to be consistent and non-trivial, in the sense that it does not contain the wff (Triv): A ≡□A. Extending WVPr∗ with the so-called Generalized Stalnaker’s Thesis (GST) yields the (first) Lewis’s Triviality Result (LTriv) in the form (◊(A ∧ B) ∧◊(A ∧ ¬B)) ⊃ PrB|A = PrB. In §4 it is shown that a consequence of this theorem is the thesis (CT1): ¬A ⊃ (A > B ⊃ A ⥽ B). It is then proven that (CT1) subjoined to the conditional system WVPr∗ yields the collapse formula (Triv). The final result is that WVPr∗+(GST) is equivalent to WVPr∗+(Triv). In the last section a discussion is opened about the intuitive and philosophical plausibility of axiom (Pr4) and its role in the derivation of (Triv).
A sociological treatment exploring the medical model in relation to the neurodiversity movement with reference to policy and practice
Authors: Casanova Emily L. , Widman Cheryl J. 
Published: March 2021

Background: The Medical Model of disability focuses on diagnosed conditions. It is used in policy particularly to categorise people. This enables predictions and forecasting about the size of policy needs but tends to homogenise disability representations, assigning a negative evaluation to illness that may be irrespective of patho-anatomical correlates. The Social Model considers disability as imposed by society through attitudes and barriers. The Neurodiversity Model is a type of social and cultural model with biological implications; it states that differences in brain and behaviour lie on a non-pathological spectrum. Critics say this whitewashes lived experience. Policymakers may devalue the Neurodiversity Model’s origins within activist neurodiverse communities. The model that policy and practice decision makers use has fundamental effects on their impacts.
Aims and objectives: The Medical and Neurodiversity Models are reviewed in reference to their politicisation as ways to characterise disability, and identity politics. The implications socially and for disability policy and practice and evidence use are considered.
Key conclusions: Both models fall short in addressing the needs of the broad community of the disabled, yet both have useful features. We propose the Biological Gradient Model (BGM), which integrates scientific theory while avoiding pathology-based concepts and value-laden judgments concerning ‘deficiency’. Its usefulness is demonstrated; it resolves some of the ambiguity and tensions that exist in the way people with disability are viewed by different groups and treated within policy. It has the potential to reduce issues of partial representation, where the voices of those who cannot self-advocate may be less heard.
Numerical analysis of the DKDP-based high-energy optical parametric chirped pulse amplifier for a 100  PW class laser
Authors: Hu Jiabing , Wang Xinliang , Xu Yi , Yu Lianghong , Wu Fenxiang , Zhang Zongxin , Yang Xiaojun , Ji Penghua , Bai Peile , Liang Xiaoyan , Leng Yuxin , Li Ruxin 
Published: March 2021

An optical parametric chirped pulse amplifier (OPCPA) based on a large-aperture DKDP crystal and pumped by a 10 kJ level Nd:glass laser can serve as the final amplifier for a 100 PW level laser. A comprehensive numerical investigation on such a high-energy OPCPA is presented in this work. The effects on the efficiency–bandwidth product induced by the deuteration level, absorption loss, temperature variation, and optimization of zero-phase-mismatch wavelength (ZPMW) are analyzed in detail. Based on the analysis above, a three-dimensional numerical simulation taking into account the effects of pumping depletion, diffraction, and walk-off shows that, by optimization of ZPMW, broadband (over 210 nm spectral width in FWHM) and high efficiency (

>

37
%

) amplification can be realized in the DKDP crystal even with a moderate deuteration level of 70%, which can relax the requirement of a high deuteration level in a large-aperture DKDP crystal. The numerical analysis can provide meaningful guidance for the design and construction of 100 PW class laser systems.
ON THE CONTENT OF THE CONCEPT OF “SUSTAINABLE DEVELOPMENT” IN INTERNATIONAL AND RUSSIAN LEGISLATION
Authors: Kalashnik N.I. , Trubnikova O.A. , Rakhimberdin K.K. 
Published: March 2021

The concept of “sustainable development” has been widely used in recent years in legislation andspecial literature. At the same time, a generally accepted definition of this concept has not been developed.The article is devoted to the study of the issues of determining the content of the concept of “sustainabledevelopment”. According to the authors, the need to address this issue is related to the problem of theeffectiveness of legal norms. The article shows the origin and formation of the concept of sustainabledevelopment in international legislation, identifies the system-forming features of sustainable development,analyzes the application and content of the term “sustainable development” in international acts andregulatory legal acts of Russia, notes its intersectoral nature, and considers some theoretical approaches tothe definition of the term “sustainable development”. The authors show the ambiguity of the application of the concept in question in the domestic legislation. In this regard, the need for the development and legalconsolidation of the term “sustainable development” at the federal level is justified.
Hawksweeds of the Putorana Plateau
Authors: Tupitsyna Natalia , Pospelov Igor N. 
Published: March 2021

An overview of all hawkweeds (Hieracium L.) recorded on the Putorana Mountains is given. The list of floristic findings of the territory of the Plateau includes 3 new species (Hieracium czamyjashense Tupitz., H. pseudarctophilum Schljakov., H. pseudofariniramum Tupitz.). New localities are also given for the endemic species H. putoranicum Tupitz. and the rare species H. subfariniramum (Ganesch et. Zahn) Ȕksip ex Tupitz.. The coordinates of collection sites, dates of collection, habitats nature, area type and an ecological-cenotic confinedness are given for each species. The nomenclature is reviewed. Field studies were carried out in 2018 in the western part of the Putorana Mountains, on the western coast of Lake Sobachye (Yt-Kyuyol) near the mouth of the Nakhta River; in 2019 in the western part of the Putorana Mountains, in the vicinity of Talnakh Town, at the Red Rocks Natural Sanctuary of regional significance; in 2020 in the south-west of the Putorana Mountains, in the vicinity of the middle part of Lake Kutaramakan (mouth of the Irkingda River) on the territory of the Putoransky Nature Reserve and its protective zone. Moreover, the herbarium specimen of H. umbellatum L. from the vicinity of Snezhnogorsk Town is published.
Fuel integrity evaluation method for BWR-6 plant Kuosheng during ATWS events
Authors: Hsu K.-H. , Chien H.-C. 
Published: March 2021

Abstract
Anticipated Transients without Scram (ATWS) are evaluated to demonstrate that during ATWS the fuel’s integrity prevents fission product release, and that the safety features the BWR-6 plant is equipped with mitigate the ATWS event. For analyzing this scenario, a RETRAN-3D system model and hot channel model of Kuosheng NPP have been developed. From all possible events those are analyzed where the main steam isolation valves close (MSIVC) when the reactor is operating at rated power conditions. For cases with low core flows this results in higher peak cladding temperatures and thicker oxidation thicknesses. All results confirm the ATWS acceptance criteria. For sensitivity cases, increasing the boron concentration of standby liquid control system (SLCS) or injecting boron of SLCS earlier were investigated. The results show, that these measures cannot decrease the PCT value immediately, but can shorten the period of peak cladding temperature over 850 °C which results in smaller oxidation thickness.
The Importance of Office Layout for Employee Productivity
Authors: Ahmad Nurbarirah , Jamin Aziean , Beta Raja Mayang Delima Mohd , Ismail Shafinar , Sakarji Siti Rosnita , Zain Zainab Mohd 
Published: March 2021

This study was conducted to explain the impact of open and enclosed plan office layouts on employee productivity.Â The subject area for this study was in Amanah Saham Pahang Berhad (ASPA). This study involved 52 respondents from Administration Department, Finance Department, Logging, Planning and development of Forest Department and Investment Department. Data collection method used a questionnaire, and descriptive analysis is used to data analysis. The results showed that the condition of employee productivity was in good condition, but the office layout did not affect employee productivity. Moreover, the results from the findings showed that only enclosed plan office had significant positive relationships and it answered research questions and supported the hypotheses presented in this research study.Â As a conclusion, this research study helps the other researcher to explore the impact of office layout on employee productivity. This research study result was supported by previous results presented at every research finding.
Analisis Kondisi Atmosfir, Indeks Labilitas, dan Citra Satelit Saat Kejadian Puting Beliung di Pontianak Kalimantan Barat (Studi Kasus 17 Juli 2020)
Authors: Saragih Rino Wijatmiko Saragih 
Published: March 2021

Puting beliung yang terjadi di Pontianak, Kalimantan Barat pada tanggal 17 Juli 2020 menyebabkan ratusan rumah rusak dan juga beberapa gedung sekolah. Kejadian puting beliung ini disebabkan oleh perubahanÂ fenomena cuaca yang yang sangat singkat. Dalam penulisan ini menggunakan metode penelitianÂ deskriptif analitis. Data yang digunakan yaitu data pengamatan udara permukaan, data udara atas radiosonde, serta data citra satelit. Hasil dari penulisan ini memperlihatkan bahwa kejadian puting beliung ini diakibatkan oleh perubahan kondisi udara permukaan, kondisi labil pada wilayah tersebut, dan adanya tutupan awan pada saat kejadian.
Rancang Bangun Sistem Monitoring Anggaran Keuangan Berbasis Web pada Biro Hukum dan Kerja Sama Luar Negeri
Authors: Ramadhan Agung 
Published: March 2021

Monitoring anggaran keuangan adalah pemantauan keluar masuknya berkas pada pengelola keuangan guna menghindari adanya kesalahan penginputan maupun ketidak tertiban dalam alur berkas keluar masuk, pengelolaan keuangan secara manual biasanya masih terdapat permasalahan yakni kesulitan dalam tertib administrasi keuangan. Hal tersebut disebabkan tidak adanya database yang terintegrasi, sehingga pihak pengelola keuangan tidak dapat memantau alur berkas secara langsung. Dan yang paling fatal adalah sering terjadinya tindakan saling tuduh pada berkas yang hilang, berkas yang masuk dan keluar tidak terjadwal dengan baik. Tujuan dari penelitian ini adalah merancang dan membangun sistem informasi yang menyajikan informasi aliran keluar masuknya berkas anggaran keuangan pada Biro Hukum dan Kerja Sama Luar Negeri. Metode pengumpulan data pada penelitian ini yaitu obervasi dan wawancara. Metode pengembangan sistem yang digunakan adalah Rapid Application Development (RAD) yang meliputi planning, analysis, design dan implementation. Alat perancangan yang digunakan adalah Unified Modeling Language (UML). Sistem ini berbasis web dibangun dengan bahasa pemrograman PHP dan MySQL sebagai database. Dengan penelitian ini, lembaga pemerintahan dapat melaksanakan dapat meminimalisir terjadinya sikap saling tuduh akibat berkas yang hilang dan tidak tertib antrian antar pengelola dan penyerapan anggaran menjadi menjadi lebih efisien dan tepat waktu.
Ketahanan Keluarga Perspektif Maslahah Mursalah dan Hukum Perkawinan di Indonesia
Authors: Arifiani Feni 
Published: March 2021

AbstractFamily resilience is currently a top priority for state initiatives that address a variety of factors that contribute to family resilience, including physical, social, and psychological aspects. Several aspects of the Marriage Law, however, are in the spotlight because they are contentious. "Every husband and wife who are legally married have the duty to love, support, and preserve honor for each other." be faithful, and provide physical and spiritual assistance to one another." The rules on feelings suggest that a married couple must communicate their feelings to one another, and this is not without reason. The four advantages of sharing feelings of love include minimizing tension caused by pent-up emotions, making it easier for couples to understand each other, and making it easier for couples to communicate with each other. Being an efficient method on occasion. Marriage, according to the Marriage Law, is a sacred relationship created by a man and a woman as husband and wife in order to form a happy and everlasting family (household) founded on Almighty divinity. A family will be created as a result of this union. Many people believe that Family Resilience is a plagiarized version of the Islamic Law Compilation (KHI), "Both husband and wife are bound by the statute." to love, respect, and aid one another from one body to another. As a consequence, what some people are referring to is an article that already exists in the Marriage Law and KHI, which has existed in previous regulations and has never been challenged. AbstrakKetahanan keluarga yang saat ini menjadi prioritas program negara yang mencakup berbagai aspek yang dibutuhkan untuk memenuhi ketahanan keluarga, seperti aspek ketahanan fisik, sosial, dan psikologis. Namun beberapa hal dalam UU Perkawinan yang menjadi sorotan karena memicu kontroversi. “Setiap suami dan istri yang terikat dalam perkawinan yang sah berkewajiban untuk mencintai, menghormati, menjaga kehormatan, setia, dan saling memberikan bantuan jasmani dan rohani”. Aturan tentang perasaan menunjukkan perlunya pasangan suami istri untuk saling mengungkapkan perasaannya, tentunya hal ini bukan tanpa alasan. Empat manfaat dalam mengungkapkan perasaan cinta antara lain mengurangi stres akibat terpendam, memudahkan pasangan untuk saling memahami, terkadang menjadi cara yang efektif. UU Perkawinan mendefinisikan pernikahan sebagai ikatan spiritual antara laki-laki dan perempuan sebagai suami istri untuk membentuk keluarga (rumah tangga) yang bahagia dan abadi berdasarkan ketuhanan Yang Maha Kuasa. Dari pernikahan ini akan terbentuk sebuah keluarga. Ketahanan Keluarga yang dipermasalahkan oleh banyak orang merupakan penjiplakan dari Kompilasi Hukum Islam (KHI), “Suami istri wajib hukumnya. untuk saling mencintai dalam cinta, menghormati dan memberi bantuan dari satu tubuh ke tubuh lainnya. Dengan demikian yang dimaksud oleh sebagian orang tersebut merupakan pasal yang sudah ada dalam UU Perkawinan dan KHI, dimana sudah ada pada peraturan sebelumnya dan tidak dipersoalkan sampai sekarang.
Digital Competence, New Perspectives for Teaching in Contexts of Social Isolation [Competencia digital, nuevas perspectivas para la docencia en contextos de aislamiento social]
Authors: Cruz Cobeñas María Amelia , Carcausto-Calla Wilfredo 
Published: March 2021

The article reviews the problem of digital competences from the digital constructivist learning approach for digital empowerment from formative education of the dimensions: (a) personal, (b) ethical, (c) professional, as opposed to the structuralist definition or functionalist of the connectivist approach, which prioritizes the professional and functional dimension of the competences in the use of information and communication technologies. Digital competences are established as the skills to achieve integration, accessibility, employability and equity of digital communities, valued in the context of the current pandemic and in virtual education, doors of a future of sustainable health and citizenship.
[El artículo revisa la problemática de las competencias digitales desde el enfoque de aprendizaje constructivista digital para el empoderamiento digital desde la educación formativa de las dimensiones: (a) personal, (b) ética, (c) profesional, en contraposición a la definición estructuralista o funcionalista del enfoque conectivista, la cual prioriza la dimensión profesional y funcional de las competencias en el uso de las tecnologías de la información y la comunicación. Se establece a las competencias digitales como las destrezas para lograr la integración, accesibilidad, empleabilidad y equidad de las comunidades digitales, valorados en el contexto de la pandemia actual y en la educación virtual puertas de un futuro de salud y ciudadanía sostenibles].