bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of an Educational Program for Public Health Nurses to Promote Local Healthcare Planning: Protocol for a Pilot Randomized Controlled Trial
Authors: Yoshioka-Maeda Kyoko , Katayama Takafumi , Shiomi Misa , Hosoya Noriko , Fujii Hitoshi , Mayama Tatsushi 
Published: April 2021

Abstract
Background: The promotion of local healthcare planning is crucial to assist public health nurses in improving community health inequities. However, there is no effective educational program for developing relevant skills and knowledge among these nurses. Therefore, this study aims to assess the feasibility and acceptability of a newly developed web-based self-learning program, designed to promote the involvement of public health nurses in the local healthcare planning process. Methods: This pilot randomized control trial will randomly allocate eligible public health nurses to intervention and control wait-list groups [1:1]. The intervention group will be exposed to six web-based learning modules from July to October 2021. After collecting post-test data, the wait-list group will be exposed to the same modules to ensure learning equity. We will then evaluate the primary outcomes by implementing a validated and standardized scale designed to measure public health policy competencies both at baseline and post-intervention, while secondary outcomes will be measured on an action scale to demonstrate the necessity of healthcare activities. The third outcome will be knowledge and skills related to local healthcare planning by public health nurses. Participants will also provide feedback on both trial feasibility and the web-based self-learning program itself, which will help us identify improvement points for continual refinement. Feedback will be given through free descriptions. Discussion: This pilot study will assess the feasibility and preliminary effects of a web-based self-learning program designed to develop the competencies of public health nurses involved in local healthcare planning. We will examine all outcome scales and data collection procedures in preparation for a future definitive randomized controlled trial. This will provide preliminary data for an intervention aimed at improving relevant competencies among public health nurses who are tasked with resolving health inequities in their respective communities through local health planning. Trial registration: The protocol for this study was registered with the University Hospital Medical Information Network Clinical Trials Registry and approved by the International Committee of Medical Journal Editors (No. UMIN000043628, March 23, 2021).
Effect of Structure-Soil-Structure Interaction (SSSI) between Three Dissimilar Adjacent Bridges
Authors: Alfach Mohanad Talal , Ayoub Ashraf 
Published: April 2021

Abstract
The present study assesses the effect of Structure-Soil-Structure-Interaction (SSSI) on the seismic behavior of three dissimilar adjacent bridges by comparing their seismic responses with the seismic response of the isolated bridge including Soil-Structure-Interaction (SSI). To this end, an extensive series of numerical analyses have been carried out to elicit the effects of Structure-Soil-Structure-Interaction (SSSI) on the seismic behavior of three dissimilar bridges with different superstructure masses. The studied bridges are based on groups of piles founded in nonlinear clay. A parametric study has been performed for configurations of three dissimilar bridges with superstructure masses ratios of 200% and 300%, concentrating on the influence of the inter-bridge spacing, and the geometrical position of the bridges towards each other and towards the seismic excitation direction. The numerical analyses have been conducted using a three-dimensional finite difference modeling software FLAC 3D (Fast Lagrangian analysis of continua in 3 dimensions). The results of the numerical simulations clearly show that the seismic responses of the dissimilar grouped bridges were strongly influenced by the neighboring bridges. In particular, the results reveal a salient positive impact on the acceleration of the superstructure by a considerable drop (up to 90.63%) and by (up to 91.27%) for the internal forces induced in the piles. Comparably, the influence of bridge arrangement towards the seismic loading were prominent on both of superstructure acceleration and the internal forces in the piles. The responses were as much as 27 times lesser for the acceleration and 11 times smaller for the internal forces than the response of the isolated bridge. Contrarily, the inter-bridge spacing has a limited effect on the seismic response of the grouped bridges.
Laser Additive Remanufacturing Parameters Optimization and Experimental Study of Heavy-Duty Sprocket
Authors: Guo Chenguang , Lv Ning , Yue Haitao , Li Qiang , Zhang Jianzhuo 
Published: April 2021

Abstract
Experimental research on laser additive remanufacturing technology of heavy-duty sprocket was carried out. The influences of laser power, scanning speed and powder feeding rate on cladding height, cladding area, melting area and dilution rate were compared and analyzed. The prediction models of the combination of process parameters with the geometric characteristics of cladding layer and dilution were established. A multi-objective process parameter optimization model with the maximum cladding height and cladding area maximum, the minimum melting area and dilution rate as objective functions was established, and the model was optimized and solved based on MOPSO algorithm. The laser additive remanufacturing repairing experiment of damaged sprocket was carried out by using the optimal parameters combination, and the microstructure and mechanical properties of the repaired region were analyzed. The results show that the scanning speed and powder feeding rate are the main factors influencing the geometric characteristics and dilution of the cladding area, and the models have good prediction accuracy. The optimal process parameters (1150 W, 950 mm/min, 3.8 rad/min) obtained by MOPSO algorithm is adopted to repair the damaged sprocket. The repaired area without cracks and pores, the cladding layer shows good metallurgical bonding with the substrate and the microhardness is twice that of the substrate. The experimental results prove that the laser additive remanufacturing technology is feasible to repair the damaged heavy-duty sprocket and has a strong engineering application prospect.
Identification, Characterization, and Tissue Expression Pattern of Alternatively Spliced Transcript Variants of Mouse RARRES2 Gene
Authors: Kwiecien Kamila , Majewski Pawel , Bak Maciej , Brzoza Piotr , Godlewska Urszula , Skulimowska Izabella , Cichy Joanna , Kwitniewski Mateusz 
Published: April 2021

Abstract
Chemerin is a chemoattractant protein with adipokine and antimicrobial properties encoded by the retinoic acid receptor responder 2 (RARRES2) gene. Chemerin bioactivity is largely dependent on carboxyl-terminal proteolytic processing that generates chemerin isoforms with the different chemotactive, regulatory and antimicrobial potential.While these mechanisms are relatively well known, a role of alternative splicing in generating isoform diversity remains obscure. Using rapid amplification of cDNA ends (RACE) PCR, we have identified novel transcript variant 4 of mouse RARRES2 encoding mChem153K. Moreover, RT-QPCR results and analysis of publicly available RNA-seq datasets showed that different alternatively spliced variants of mouse RARRES2 are present in mouse tissues, and their expression pattern was not affected by inflammatory nor infectious stimuli. Finally, we demonstratedthat chemerin isoform mChem157S exhibits higher bactericidal but not chemotactic activity compared to mChem156S. Together, our findings highlight the importance of an alternative splicing in generation of chemerin isoforms diversity and activity.
Preventive measures against the COVID-19 pandemic in Mexico: A cross-sectional study
Authors: Ibarrola-Peña Juan Carlos , Barbosa-Camacho Francisco José , Almanza-Mena Yolanda Lorelei , Chejfec-Ciociano Jonathan Matias , Reyes-Elizalde Emilio Alberto , Romero-Limón Olaya Moramay , Zaragoza-Organista Rafael , Cervantes-Pérez Enrique , Sapién-Fernández José Hector , Guzmán-Barba José Aldo , Flores-Becerril Paola , López-Zendejas Martín , Fuentes-Orozco Clotilde , Cervantes-Guevara Gabino , Miranda-Ackerman Roberto Carlos , González-Ojeda Alejandro 
Published: April 2021

Abstract
Background: In December 2019, the World Health Organization announced a new viral pneumonia due to SARS-CoV-2, which originated in Wuhan, China. In Mexico, the official announcement regarding the first coronavirus disease 2019 (COVID-19) case was made on February 29, 2020. Understanding how Mexicans behave during the pandemic could present a complete picture of the pandemic in Mexico while providing better handling of the pandemic.Methods: This was a cross-sectional survey in which we inquired about the Mexican population's behavior and preventive measures. In total, 4004 subjects from the general population responded to the survey. The survey comprised a questionnaire that included demographic data, housing conditions, daily coexistence with people, use of preventive measures, confidence in the Mexican health-care sector, acceptance of medical procedures, and knowledge of COVID-19.Results: Participants' mean age was 30 ± 13.7 years, and 43.8% of participants reported at least one comorbidity. Almost 99% of the participants mentioned knowing the symptoms of COVID-19. Moreover, 68.1% of them lived with three to five cohabitants, and 87.4% of them stated that at least one household member had to break social isolation every week. Although 77.5% of participants considered that they followed proper social distancing measures, 60% of them mentioned that they knew at least six individuals who did not follow social distancing measures. Furthermore, 96.2% of participants reported using preventive measures at least 50% of the time. Face masks were used by 99.5% of them, but only 51.3% used a certified mask.Conclusions: The COVID-19 pandemic outcomes in Mexico are the result of multiple negative factors, such as high rates of comorbidities (e.g., diabetes and hypertension); a high number of people living together at home, with many people breaking social isolation; and most of the population using noncertified preventive measures, which may not have the necessary effectiveness.
Surgical Treatment of Pediatric and Adolescent Papillary Thyroid Cancer: a Retrospective Study of 54 Patients in a Single Center
Authors: Su Yanjun , Cheng Shaohao , Zhang Min , Liu Wen , Diao Chang , Ma Yunhai , Qian Jun , Cheng Ruochuan 
Published: April 2021

Abstract
Background: In 2015, American Thyroid Association (ATA) issued the first version of Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. The purpose of this study is to evaluate whether the ATA pediatric guidelines recommended surgical approach for the patient can be applied to surgical treatment of pediatric PTC in China.Method: From April 2012 to December 2020, clinical data of children (≤18 years) with PTC consecutively admitted and treated with initial surgery in our department were retrospectively reviewed. Result: A total of 54 children with PTC were enrolled in the study. We find that central lymph node metastasis (CLNM) rate was significantly higher than that in the lateral neck (83.33 % vs 62.96%，χ2= 5.704, p= 0.017), and the CLNM rate and LLNM rate both gradually increased with increasing of T stage. The lymph node metastasis rate was significantly lower in cN1b (-) patients than in cN1b (+) patient following routine CND (55.00% vs 100.00%, χ2=15.263, p=0.000). Meanwhile, the CLNM and LLNM rates of ipsilateral were significantly higher than those of contralateral central compartment (83.33％vs 57.41％%, χ2=8.704, p= 0.003) and contralateral lateral compartment (62.96% vs 31.48%, χ2 =10.737, p= 0.001). lymph nodes of 51 lateral LND from 34 children with cN1b (+) were analysed, which revealed the LNM rate of cN1b (-) patients was significantly lower than that of cN1b (+) patients (55.00% vs 100.00%, χ2 =15.263, p=0.000). Meanwhile, the CLNM and LLNM rates of ipsilateral were significantly higher than those of contralateral central compartment (83.33％vs 57.41％%, χ2=8.704, p= 0.003) and contralateral lateral compartment (62.96% vs 31.48%, χ2 =10.737, p= 0.001).Conclusion: Pediatric and adolescent PTC is characterized with high involvement of CLNM and LLNM at the time of diagnosis. TT should be conducted in the majority of children with PTC, and lobectomy with isthmustomy should be selectively applied. CND should be routinely performed, therapeutic LND is recommended for children with cN1b (+), SLND including level II-V is preferred, and SSLND should be performed with caution. Based on single-center data, we believe that the 2015 ATA guidelines for children are applicable to the surgical treatment of PTC in domestic children.
Alarm Method of Communication Intelligent Manhole Cover Based on Multiple Event Fusion
Authors: li chengfan , gu shanming , guo gang , liu xuefeng , liu lan , zhao junjuan 
Published: April 2021

Abstract
Communication intelligent manhole cover (CIMC) can effectively, accurately and in real time monitor the status change of communication manhole cover and helps protect the safety of communication pipeline and the comprehensive utilization of pipeline resources. The traditional monitoring method often leads to frequent false alarms due to the complex working environment of manhole cover and the random error of sensor. In terms of the equipment status signals generated by the CIMC terminal, a new alarm method of CIMC with multiple event fusion in this paper via jointing analysis of multi-sensor status signals is proposed on the basis of abnormal alarm events definition. The experimental result shows that the proposed CIMC alarm method by means of multiple sensor signals in this paper can not only make up for the defect that it is difficult to fully reflect the real state of manhole cover by a single sensor, but also reduces the false alarm rate caused by the random error of sensor and CIMC system. It has better practicability for the intelligent management of manhole cover and be conducive to the construction of intelligent transportation and smart city.
Evolution of mechanisms controlling epithelial morphogenesis across animals: new insights from dissociation - reaggregation experiments in the sponge Oscarella lobularis
Authors: Vernale Amélie , Prünster Maria Mandela , Marchianò Fabio , Debost Henry , Brouilly Nicolas , Rocher Caroline , Massey-Harroche Dominique , Renard Emmanuelle , Bivic André Le , Habermann Bianca H. , Borchiellini Carole 
Published: April 2021

Abstract
Background: The ancestral presence of epithelia in Metazoa is no longer debated. Even though Porifera seem to be the best candidates to be the sister group to all other Metazoa, hardly anything is known about the proteins involved in the composition of cell-cell junctions or about the mechanisms that regulate epithelial morphogenetic processes in this phylum. Results: To get insights into the early evolution of epithelial morphogenesis, we focused on morphogenic characteristics of the homoscleromorph sponge Oscarella lobularis. Homoscleromorpha are a sponge class with a typical basement membrane and adherens-like junctions unknown in other sponge classes. We took advantage of the dynamic context provided by cell dissociation-reaggregation experiments to explore morphogenetic processes in epithelial cells in an early lineage by combining fluorescent and electronic microscopy observations and RNA sequencing approaches at key time-points of the dissociation and reaggregation processes. Conclusions: Our results show that part of the molecular toolkit involved in the loss and restoration of epithelial features such as cell-cell and cell-matrix adhesion is conserved between Homoscleromorpha and Bilateria, suggesting their common role in the last common ancestor of animals. In addition, Sponge-specific genes are differently expressed during the dissociation and reaggregation processes, calling for future functional characterization of these genes.
Assessment of Heat Stress and Cloudiness Probabilities in Post-Flowering of Wheat and Canola in The Southern Cone of South America
Authors: Rivelli Gonzalo Martín , Long María Elena Fernández , Abeledo Leonor Gabriela , Calderini Daniel , Miralles Daniel Julio , Rondanini Deborah Paola 
Published: April 2021

Abstract
Episodes of heat stress constrain crop production and will be aggravated in the near future according to short and medium-term climate scenarios. Global increase in cloudiness has also been observed, decreasing the incident solar radiation. This work was aimed to quantify the probability of occurrence of heat stress and cloudiness, alone or combined, during the typical post-flowering period of wheat and canola in the Southern Cone of South America. Extended climate series (last 3-5 decades with daily register) of 33 conventional weather stations from Argentina, Brazil, Chile and Uruguay (23ºS to 40ºS) were analysed considering the period from September to December. Two different daily events of heat stress were determined: i) maximum daily temperature above 30ºC (T>30ºC), and ii) 5ºC above the historical average maximum temperature of that day (T+5ºC). A cloudiness event was defined in our work as incident solar radiation 50% lower than the historical average radiation of that day (R50%). The T>30ºC event increased its probability of occurrence throughout the post-flowering phase, from September to December. By contrast, the risk of T+5ºC event decreased slightly, just like for R50%, and the higher the latitude, the lower the probability of R50%. The T>30ºC plus R50% combined stresses reached greater cumulated probabilities during post-flowering, compared to T+5ºC plus R50%, being 42% vs. 15% in northernmost locations, 26% vs. 19% in central (between 31ºS to 35ºS), and 28% vs. 1% in southernmost locations, respectively. A curvilinear relationship emerged between the monthly probability of combined stresses and the number of days with stress per month. In summary, T>30ºC was the most frequent thermal stress during post-flowering in wheat and canola. Both combined stresses had a noticeable risk of occurrence, but T>30ºC plus R50% was the highest. Evidence of the recent past and current occurrence of heat stress individually, and its combination with cloudiness events during post-flowering of temperate crops, serves as a baseline for future climate scenarios in main cropped areas in the Southern Cone of South America.
Comprehensive analysis of the expression and prognosis for COL4A family genes in kidney renal clear cell carcinoma
Authors: Qian Jun , Tu Bizhi , Jia Yaya , Wei Laifu , Gao Fei , Zhang Yiqun , Sha Qi 
Published: April 2021

Abstract
Background

COL4A family genes are a group of genes related to the extracellular matrix, which have been proven to be associated with various cancers. However, its relationship with kidney renal clear cell carcinoma (KIRC) has not been reported.
Methods

Hence, we obtained the data of differential expression and survival time of COL4A genes in KIRC from an online open-access database including ONCOMINE, UALCAN, GEPIA, Cancer Genome Atlas (TCGA) database, cBioPortal, Metascape, and STRING.
Results

We found significant overexpression in COL4A1, COL4A2 while COL4A 3, COL4A4, COL4A5, and COL4A6 has decreased in tumor tissues. Moreover, almost all COL4A family genes obviously correlated with individual cancer stages of KIRC; and higher expression of COL4A1/2/3/BP/4 was found to accompany better overall survival time (OS) while COL4A5 with a lower OS in KIRC patients. We also found that the COL4A genes altered group had longer OS and DFS than unaltered teams.
The association of TNF-α promoter polymorphisms with genetic susceptibility to cervical cancer in a Chinese Han population
Authors: Yang Jia , Wang Yingying , Yan Zhiling , Li Chuanyin , Liu Shuyuan , Liu Weipeng , Zhang Xinwen , Yao Yufeng , Shi Li 
Published: April 2021

Abstract
Background
The Tumour necrosis factor-α (TNF-α) gene plays an important role in the host immune response. Recent studies have found that TNF-α also plays an important role in cancer. Polymorphism of the TNF-α promoter region is considered to influence its transcription and be a risk factor for tumorigenesis. In the current study, we evaluated the role of TNF-α promoter region polymorphisms in susceptibility to cervical intraepithelial neoplasia (CIN) and cervical cancer (CC).
Methods
A total of 2,732 subjects, including 1,173 healthy controls, 579 patients with CIN and 980 patients with cervical cancer in a Chinese Han population, were selected for the current study. Five SNPs in the TNF-α promoter, rs1799964 (C > T), rs800630 (A > C), rs1799724 (C > T), rs1800629 (A > G) and rs361525 (A > G), were selected and genotyped using TaqMan Assays. The association of these SNPs with cervical cancer was evaluated among healthy controls and CIN and cervical cancer patients.
Results
The frequency distribution of rs1800629 and rs361525 alleles was significantly different between the cervical cancer group and the control group (P = 0.009 and P = 0.002). The A alleles of rs1800629 and rs361525 were found to be a protective factor (OR = 0.722; 95%CI = 0.564–0.923) and a risk factor (OR = 1.693; 95%CI = 1.205–2.378) for cervical cancer, respectively. In comparison of different pathological types of cervical cancer group and the control group, the distribution of allele frequencies of rs1800629 and rs361525 was significantly different between the squamous cell carcinoma and control groups (P = 0.002 and P < 0.001). The A alleles of rs1800629 and rs361525 were protective (OR = 0.659; 95%CI = 0.502–0.864) and risk (OR = 1.868; 95%CI = 1.317–2.648) factors for cervical squamous cell carcinoma, respectively.
Conclusion
rs1800629 and rs361525 in the TNF-α promoter are associated with susceptibility to cervical cancer and squamous cell carcinoma in the Chinese Han population.
Increased Early Mortality After Fludarabine and Melphalan Conditioning with Peripheral Blood Grafts in Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide
Authors: Eastburg Luke , Russler-Germain David , DiPersio John , Fountaine Thomas , Andolina Jeffrey , Abboud Ramzi , Huselton Eric 
Published: April 2021

Abstract
Due to the evolving use of haploidentical donor grafts in hematopoietic cell transplantation, there is increased need to better understand the risks and benefits of using bone marrow versus peripheral blood grafts, as well as how specific pre-transplantation conditioning regimens impact patient safety and treatment outcomes. We performed a retrospective analysis of 38 patients at two centers who specifically underwent haploidentical hematopoietic cell transplantation using fludarabine plus melphalan-based conditioning regimens with post-transplant cyclophosphamide and peripheral blood donor grafts. We observed an unexpectedly high rate of early non-relapse mortality of 21% at 100 days and 34% at 1-year. In addition, 40% of all patients suffered from severe cytokine release syndrome and 45% of all patients suffered from kidney injury, often necessitating renal replacement therapy. The poor outcomes with 1-year overall survival of 34%, disease-free survival of 29%, and non-relapse mortality of 34% motivate us to reconsider the appropriateness of the combination of fludarabine and melphalan conditioning with T-cell replete peripheral blood grafts in the setting of haploidentical hematopoietic cell transplant with post-transplant cyclophosphamide.