bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Prediction of Polygonal Helical Curved Tube by Abrasive Flow Precision Machining
Authors: Li Junye , Zhu Shangfu , Zhu Jinbao , Xu Chengyu , Zhang Hengfu , Shi Guangfeng , Zhao Weihong , Liu Jianhe 
Published: July 2021

Abstract
Polygonal helical curved tube is the main form of rifling barrel, which surface quality determines the shooting accuracy of gun. Abrasive flow machining (AFM) technology can significantly improve its inner surface quality. In order to study the influence of AFM technical parameters on the inner surface quality of polygonal helical curved tube, orthogonal experimental design (OED) was used as the research method in this paper. By means of analysis of variance (ANOVA) of experimental data, the degree of influence of inlet pressure, abrasive concentration, abrasive particle size and machining time on the inner surface quality of polygonal helical curved tube was determined, and the optimal combination of process parameters was obtained. Under the optimal process parameters, the surface roughness Ra value in the inlet area of polygonal helical curved tube was reduced to 0.098 µm. The surface quality was significantly improved. Based on the regression analysis of experimental data, the quality prediction model of polygonal helical curved tube roughness by AFM was established to realize the effective prediction of surface quality after machining. The fitting value calculated by the model with optimal process parameters is close to the experimental value, which proves the accuracy and validity of the prediction model.
Upregulated NLGN1 predicts poor survival in colorectal cancer
Authors: Yu Qian , Wang Xiaojie , Yang Yinghong , Chi Pan , Huang Jianping , Qiu Shengliang , Zheng Xin , Chen Xiaowen 
Published: July 2021

Abstract
Background: Neuroligin1 (NLGN1) is a main component of excitatory glutamatergic synapses complex and is important for synapse assembly and function. The clinical value of NLGN1 in colorectal cancer (CRC) is not clear. Methods: We obtained the expression data of 1143 CRC patients from 3 independent Gene Expression Omnibus (GEO) datasets (GSE32323, GSE24551, GSE39582) and The Cancer Genome Atlas (TCGA) to make the comparison of the NLGN1 expression level between CRC tissues and matched noncancerous tissues, and to evaluate its value in predicting survival of CRC patients. At the protein level, these results were further confirmed by immunohistochemical staining of 52 CRC samples in our own centre. Finally, the function of NLGN1 was explored by gene set enrichment analysis (GSEA). Results: Increased mRNA and protein levels of NLGN1 expression were associated with worse overall survival or recurrence-free survival in CRC patients from 2 GEO datasets, the TCGA database, and our cohort. In addition, multivariate regression analysis showed that NLGN1 was an independent poor prognostic factor of survival in patients with CRC in TCGA database (OR = 2.524, P = 0.010). Functional analysis revealed that NLGN1 was correlated with function involving the Hedgehog signaling pathway, mismatch repair process, and some material metabolism processes. Conclusions: This study is the first to implicate and verify NLGN1 as a new poor prognostic marker for CRC.
Spread of Carbapenem-Resistant Enterobacteriaceae in a Region, China: How to Control?
Authors: Wang Jiansheng , Yin Changfu , Yang Weiwei , Lv Yuanpeng , Zhao Peng 
Published: July 2021

Abstract
Background

The increasing number of carbapenem-resistant Enterobacteriaceae (CRE) has become a serious problem globally. This study aimed to elucidate their geographically epidemiological characteristics and explore evidence-based infection control measures.
Results

A total of 930 phenotypically confirmed CRE isolates collected from 19 hospitals were genotypically characterised. K.pneumoniae (KP) and E.coli isolates were 787 (85.17%) and 96 (10.39%) among 924 carbapenemase-producing Enterobacteriaceae (CPE) isolates. Two major carbapenemase genes KPC-2 and NDM in CPE isolates accounted for 84.63% (n = 782) and 13.74% (n = 127). ST11 comprised 86.32% (631/731) of KPC-2 KP isolates. Wzi typing could discriminate ST11 KP clones and precisely track their transmission. Conjugation assays demonstrated that Some KPC-2- and NDM-bearing plasmids could be conjugatively transferred. The transferability was influenced by different STs and different wzis. CRE patients were becoming increasingly younger due to nosocomial CRE acquisition. The average length of hospitalization of these patients showed a downward trend mainly due to significant increases in voluntarily discharged rates and mortality rates. No associations between the rates of antibiotics consumption and CRE prevalence were observed. Evidence-based measures could effectively reduce the prevalence of ST11-wzi209 clone but failed to control the dissemination of ST11-wzi141 KP clone.
Conclusions

Continued vigilance for the importations should be maintained. Coordinated regional interventions are urgently needed to reduce CRE threat.
Enteric methane emission by Lactating and Dry cows in rye grass-clover pasture in the high Andean zone of Peru
Authors: Salas-Riega Catherine Yasmín , Osorio Sandra , Gamarra Julyssa del Pilar , Alvarado-Bolovich Victor , Osorio Cesar , Gomez Carlos 
Published: July 2021

Abstract
The objective of the study was to determine the enteric methane emissions from lactating and dry cows fed on rotational grazing on ryegrass/clover with supplementation of oat and vetch forage in the Andes of Peru. Sulfur hexafluoride (SF6) tracer gas methodology was used to determine enteric methane emission; the external marker Titanium dioxide (TiO2) to determine the production of feces and the protein in feces was used to estimate the digestibility of the feed. The enteric methane emissions of 5 lactating cows (LC) and 6 dry cows (DC) Brown Swiss breed were 358.5 and 337.4 g CH4/cow/day for LC and DC, respectively (P> 0.05). The conversion factor from gross energy to methane (Ym;%) was 9.7 for LC and 9.6 for DC. The enteric methane yield per kilogram of organic matter consumption was 32.5 g CH4/lactating cow /day and 32.2 g CH4/dry cow/day (p> 0.05) and the emission per kilogram of metabolic live weight for lactating cows was 3.1 g CH4/kg PV0.75 and for dry cows 2.9 g CH4/kg PV0.75 (P> 0.05). It was concluded that enteric methane emissions are similar for lactating cows and dry cows measured with the SF6 tracer gas technique.
Research on Low-density Cross-border Support Technology For Large-section Coal Roadway in Shallow-buried Thick Coal Seam
Authors: Yan Shiping , guo feng , Chen Fei , Cao Yuxiang , He Zhe 
Published: July 2021

Abstract
The slow excavation speed of coal roadways has always been a key factor restricting the safe and efficient production of large-scale coal mines in China, and the problem of unbalanced mining replacement caused by this is widespread. This paper takes the S1231 heading face of the Ningtiaota coal mine of Shaanxi Coal and Chemical Industry Group as the research object, analyzes the characteristics of the stress evolution of coal roadway driving, reveals the principle of low-density cross-border support, and proposes a low-density cross-border support plan. . Using FLAC 3D to study the roadway stress-displacement evolution law of the new support scheme during the driving and mining phases, the results show that the peak stress during the driving is 5.3 Mpa, and the coal pillar side stress concentration is the most obvious during the mining period, with the peak value being 7.9 Mpa. The moving distances of the two banks are both 10 mm, which verifies the feasibility of low-density cross-border support. Field application shows that during roadway excavation, the amount of roof subsidence and the displacement of the two sides are 9 mm and 11 mm, respectively, and the development depth of roof cracks is controlled within 0.5m. The overall control effect is good, and the speed of coal roadway driving is increased by 77.19% compared with the original. The new support builds a thick roof anchor structure to ensure the safety and stability of the roadway. At the same time, by reducing the number of bolts, the bolt support time has been greatly reduced, effectively alleviating the tight situation of mining replacement, and providing solutions for mines under the same conditions.
A novel Levator Ani Midurethral Support Via Single Vaginal Incision to Treat Stress Urinary Incontinence: Case Report
Authors: Lam Lai-Yet , Santos-Cortes Janice , O'Rourke Timothy 
Published: July 2021

Abstract
IntroductionA novel native tissue midurethral support procedure, Levator Ani Midurethral Support via single vaginal incision, to treat patients with stress urinary incontinence is introduced in this case report. After mesh controversy, there is a need for a minimal invasive native tissue surgical procedure to treat stress urinary incontinence with minimal complication.Case PresentationA 51-year-old female with stress urinary incontinence had three mesh midurethral slings and one autologous fascia sling with severe infection that failed. She developed recurrent stress urinary incontinence and coital incontinence. After she was referred to our care, she was initially treated with urethral bulking injections which also failed. There were few alternatives left after failure of three mesh midurethral slings, one autologous fascia sling with severe infection and urethral bulking injections. The patient was successful treated with our novel native tissue midurethral support procedure, Levator Ani Midurethral Support via single vaginal incision. She remains continent 23 months after the Levator Ani Midurethral Support via single vaginal incision and her coital incontinence has also resolved. She reported she has no pelvic pain or dyspareunia. ConclusionsAfter further study, this novel native tissue midurethral support procedure, Levator Ani Midurethral Support via single vaginal incision may meet the need for a minimal invasive native tissue surgical procedure for the treatment of stress urinary incontinence with minimal complication.
Predictive markers of transmission in areas with different malaria endemicity in north-eastern Tanzania based on seroprevalence of antibodies against Plasmodium falciparum
Authors: Kaaya Robert Diotrephes , Kajeguka Debora C , Matowo Johnson J , Ndaro Arnold J , Mosha Franklin W , Chilongola Jaffu O , Kavishe Reginald A 
Published: July 2021

Abstract
Objective The objective of this study was to assess Plasmodium falciparum exposure in areas with different malaria endemicity in north-eastern Tanzania using serological markers; PfAMA-1 and PfMSP-119.Results Bondo had a higher seroprevalence 36.6% (188) for PfAMA-1 as compared to Hai 13.8% (33), χ2=34.66, p<0.01. Likewise, Bondo had a higher seroprevalence 201(36.6%) for PfMSP-1 as compared to Hai 41 (17.2%), χ2 =29.62, p<0.01. Anti-PfAMA-1 titters were higher in malaria positive individuals (n = 47) than in malaria negative individuals (n = 741) (p = 0.07). Anti-PfMSP-1 antibody concentrations were significantly higher in malaria-positive individuals (n = 47) than in malaria-negative individuals (n = 741) (p = 0.003).Antibody response against PfAMA-1 was significantly different between the three age groups; <5 years, 5 to 15 years and >15 years in both sites of Bondo and Hai. Likewise, antibody response against PfMSP-119 was significantly different between the three-age groups in the two sites. (p<0.001). We also found significant differences in the anti-PfAMA-1and anti-PfMSP-119 antibody concentrations among the three age groups in the two sites (p=0.004 and 0.005) respectively. Immunological indicators of Plasmodium falciparum exposure have proven to be useful in explaining long-term changes in the transmission dynamics especially in low transmission settings.
Palladium-catalyzed selective oxidative amination of olefins with Lewis basic amines
Authors: Jin Yangbin , Li Chunsheng , Li Meng , Wu Wanqing , Jiang Huanfeng 
Published: July 2021

Abstract
Amines are prominent in natural products, pharmaceutical agents, and agrochemicals. Moreover, they are synthetically valuable building blocks for the construction of complex organic molecules and functional materials. However, amines, especially aliphatic and aromatic amines with free N-H, are prone to coordinate with transition-metal and deactivating the catalyst, posing a tremendous challenge to the application of Lewis basic amines in the amination of olefins. Herein we present the first case of oxidative amination of simple olefins with various Lewis basic amines. The combination of a palladium catalyst, 2,6-dimethyl-1,4-benzoquinone (2,6-DMBQ), and a phosphorous ligand leads to the efficient synthesis of alkyl and aryl allylamines. A series of allylamines are obtained with good yields and excellent regio- and stereoselectivities. Intramolecular amination to synthesize tetrahydropyrrole and piperidine derivatives was also realized. Mechanistic investigations reveal that the reaction undergoes allylic C(sp3)-H activation and subsequent functionalization.
Design, Implementation and Management of an International Medical Device Registry
Authors: Mauch Herbert , Kaur Jasmin , Irwin Colin , Wyss Josie 
Published: July 2021

Abstract
Background
Registries are powerful clinical investigational tools. More challenging, however, is an international registry conducted by industry. That requires considerable planning, clear objectives and endpoints, resources and appropriate measurement tools.
Methods
This paper aims to summarize our learning from ten years of running a medical device registry monitoring patient-reported benefits from hearing implants.
Results
We enlisted 113 participating clinics globally, resulting in a total enrolment of more than 1500 hearing-implant users. We identify the stages in developing a registry specific to a sensory handicap such as hearing loss, its challenges and successes in design and implementation, and recommendations for future registries.
Conclusions
Data collection infrastructure needs to be maintained up to date throughout the defined registry lifetime and provide adequate oversight of data quality and completeness. Compliance at registry sites is important for data quality and needs to be weighed against the cost of site monitoring. To motivate sites to provide accurate and timely data entry we facilitated easy access to their own data which helped to support their clinical routine.
Trial registration:
ClinicalTrials.gov NCT02004353
In Vitro Antibacterial Activities of the Tibetan Herbal Medicines Against the Staphylococcus Isolated From Mastitis of Guanzhong Dairy Goat
Authors: Liu Xiaoqiang , Qiu Fang , Hou Simeng , Guo Jingjing , Liu Lianjie 
Published: July 2021

Abstract
Background: Dairy goat mastitis is one of the most significant disease with effect on Guanzhong dairy goat breeding. The purpose of this study was to screen the pathogenic bacteria from milk samples of the mastitis of Guanzhong dairy goat and evaluate the antibacterial activities of six Tibetan herbal medicines, including Swertia bimaculata, Gentiana urnula, Uncaria rhynchophylla, Aconitum flavum, Dracocephalum tanguticum and Lagotis brachystachy on Staphylococcus isolated. Results: Fifty-two bacteria species, and a total of 149 different isolates were identified from 55 milk samples, and Staphylococcus was the predominant species as it accounted for 36.91% (55/149) of the identified isolates, and S. aureus (26/55) was the majority of the Staphylococcus isolates. Histopathological examination showed that obvious pathological changes were observed in the liver, kidney and lung tissues of the mice infected with S. aureus. Most of the Staphylococcus isolates expressed the multidrug resistance except for S. aureus and S. hemolyticus. The water extracts of several Tibetan medicinal plants exhibited distinguished in vitro antibacterial activities for the Staphylococcus, especially the S. aureus as well as the MDR isolates. Lagotis brachystachy has the most significant antibacterial activity, and followed by the Aconitum flavum, Uncaria rhynchophylla, Swertia bimaculata, and Dracocephalum tanguticum, while the Gentiana urnula showed the weaker inhibitory effects to the tested Staphylococcus isolates. Conclusion: This study indicated that Tibetan herbal medicines could be a potential candidate for the treatment the mastitis of dairy goat in clinical application.
Recovery Responses of Freshwater Phytoplankton Assemblage After the Disappearance of Metal Toxicity in Semi-Continuous Cultures
Authors: Tripathi B. N. , Gaur J. P. 
Published: July 2021

Abstract
The present study demonstrates the recovery of phytoplankton assemblage from metal stress. Phytoplankton assemblage consisting of different freshwater algal species isolated from a tropical pond was exposed to sublethal concentrations of Cu and Zn for 25 days in semi-continuous culture (Toxicity phase). Subsequently, algal assemblage grown in the toxicity phase were transferred to the fresh culture medium without elevated levels of the test metals for 25 days in semi-continuous culture (Recovery phase). We monitored the total biovolume of each algal species during the toxicity and recovery phases. The members of Cyanophyta were most sensitive against metal toxicity, followed by the members of Bascillariophyta. However, the members of Chlorophyta showed relatively lesser sensitivity against test metals. Among chlorophytes, Scendesmus opolinensis and Cosmarium bioculatum were tolerant to both the test metals. Metal-stressed algal species showed recovery after transferring to the basal medium depending on the concentration of metals during the toxicity phase. The members of Cyanophyta were unable to recover from metal stress. However, members of Chlorophyta showed faster recovery than others from Zn stress, and the members of Bascillariophyta showed quicker recovery from Cu stress. The differential abilities of various algal species to recover from metal stress perhaps depend on their ability to counterbalance metal toxicity. Further, research is warranted to characterize the differential ability of various algal groups to recover from metal stress. The present findings would help understand the efficiency of different algal groups to restore their position within the freshwater algal community after the disappearance for metal stress.
Migrant Economic Behaviors: Causal Effects of Health Education on Saving Rates, Social Medical Insurance, and House Purchasing
Authors: Chunfeng Dong , YOU JIALU , Zhang Jinhua 
Published: July 2021

Abstract
BackgroundsHealth China as the essentials policy with advancing Global Health, contributing to decline the inequality between rural and urban health education, and recovering the domestic markets after Coronavirus. The goal of this study is to evaluate the economic returns on health educations in a developing country. MethodsWe combine life cycle mechanisms and safety beliefs to evaluate continuous values of health education from 720,900 migrants’ economic behaviors through the ERM model, average treatment effects, and heterogeneous treatment effects robust empirically approach.ResultsWe find that health education positively affects participation in social medical insurance and house purchasing. In contrast, the relationship between health education and saving rates is an inverted ‘U’ shape. Heterogeneous treatment effect empirically robust account for heterogeneity in the previous generation and young generation; urban citizenship and rural citizenship continuous effects of health education. ConclusionThe finding suggests that health education stimulates immigrant consumption behaviors; however, extra health education is not a wise policy. Rural-urban citizenship acquisition bias is a significant factor of health education effects differential.JEL CLASSIFICATIONI15; D14; R23
Whole-genome Sequencing Reveals Putative Underlying Mechanisms of Biocontrol Capability of IBFCBF-5
Authors: Luo Chen , Shen Airong , Ren Yesong , Zhai Yang , Cheng Yi , Xu Jianping , Wei Lin , Li Jilie , Zeng Liangbin 
Published: July 2021

Abstract
Objective: As the world's food safety and environmental safety problems become increasingly severe, the agricultural sectors of various countries are also paying closer attention to the use of biofertilizers and biocontrol agents. Rhizosphere bacteria are a significant source of commonly used biofertilizers and biocontrol agents. This study aims to describe the genome and genomic traits of a biocontrol agent in the genus Bacillus.Results: In this paper, a strain of Bacillus amyloliquefaciens IBFCBF-5 was isolated and identified to have an inhibitory effect on several common oomycete and fungal pathogens Phytophthora capsica, Sclerotinia sclerotiorum, Colletotrichum gloeosporioides, and Fusarium oxysporum f.sp. cucumerinum. The genome of strain IBFCB-5 was sequenced, and the assembled genome was 4,338,658bp, with a G+C content of 46.05%. The IBFCBF-5 genome contains abundant GH, GT, CE, PL, AA, and CBM gene families, potentially degrading cellulose and hemicellulose, chitin, starch, xylan, peptidoglycan, etc. In addition, 14 lipopeptide and polypeptide antibiotic gene clusters were found in IBFCBF-5, including those coding for the synthesis of several known antifungal and antibacterial compounds Fengycin, Bacilysin, Bacillibactin, and plantazolicin.Conclusion: Our results show that Bacillus amyloliquefaciens IBFCBF-5 has a broad-spectrum antifungal ability and that its genome contains many genes coding for antimicrobial metabolites.
Do Oral hygiene and Diet Favor The Development of Non-Carious Cervical Lesions? A Retrospective Study.
Authors: deLlanos-Lanchares Hector , Alvarez-Menendez Leticia , Alvarez-Riesgo Jose Antonio , Celemin-Viñuela Alicia , Serrano-Belmonte Ildefonso , Alvarez-Arenal Angel 
Published: July 2021

Abstract
Purpose: The aim of this retrospective case-control study was to evaluate the influence of dental brushing factors, diet, the consumption of acidic drinks and Community Periodontal Index of Treatment Needs (CPITN) on the development of non-carious cervical lesions (NCCLs). Methods: The sample consisted of undergraduate dentistry students from different Spanish faculties (age range 18 to 29 years). NCCLs and the CPITN were diagnosed and recorded using a periodontal probe. A questionnaire was used to record different brushing factors, the consumption of extrinsic acids and the presence of intrinsic acids. The data obtained were analysed using unconditional uni- and multivariate logistic regression (significance lecel p<0.05). Results: Brushing force was a risk factor (OR=1.71). The presence of NCCLs is significantly more frequent in subjects who brush their teeth vigorously Frequent consumption of salads with vinegar or lemon increases the risk of NCCLs (OR=4.5). As the CPITN score increases, the risk of NCCLs also increases significantly (OR=1.93) for value 1 and OR=6.49 for CPITN of 3. The consumption of extrinsic acids associated with salads seasoned with vinegar or lemon, the brushing force and the CPITN were the risk factors. The model obtained has a 67.14% predictive capacity for NCCLs, a specificity of 76.43%, and a sensitivity of 57.86%. Conclusions: the results of this study show that brushing force, and acidic diet and CPITN significantly increase the risk of NCCLs. Other variables are needed to increase model prediction.