bluuebunny/crossref_metadata_2025_split huggingface dataset:
The negative association between trait mindfulness and post‐traumatic stress disorder: A 4.5‐year prospective cohort study
Authors: Gibert Lionel , El Hage Wissam , Verdonk Charles , Levy Bernard , Falissard Bruno , Trousselard Marion 
Published: August 2021

AbstractObjectivePost‐traumatic stress disorder (PTSD) is a chronic, disabling condition. Our main objective is to investigate the association between trait mindfulness and PTSD over a period of 54 months. The secondary objective is to provide an exhaustive description of PTSD trajectories after the Bataclan attack.MethodsWe designed a prospective cohort study of 133 subjects present in the Bataclan concert hall during the November 2015 terrorist attack in Paris, France. Data were recorded 6, 18, 30, and 54 months after the attack. The primary endpoint was evaluated using the PTSD Check List Scale. Trait mindfulness was measured by the 14‐item Freiburg Mindfulness Inventory.ResultsFMI scores were consistently, significantly, and negatively associated with PCL‐5 scores. Adjusted odds ratios were at 0.81 (6 months), 0.88 (18 months) 0.82 (30 months), and 0.81 (54 months). PTSD prevalence 6 months after the event was 77%; it remained at 41% after 54 months. PTSD status of subjects is fluctuating. Latent class analysis divided the cohort into 3 groups: 21% of subject who remained below PTSD threshold throughout, 30% who remained above throughout, and 49% who steadily reduced their PTSD scores over time.ConclusionIn our cohort, mindfulness is negatively associated with PTSD. Mindfulness programs are designed to improve global resilience and treat anxiety and mood disorders. Further research is needed to investigate if improving trait mindfulness is possible and beneficial for patients suffering from PTSD.
Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor
Authors: Imai Hisao , Kaira Kyoichi , Hashimoto Kosuke , Nitanda Hiroyuki , Taguchi Ryo , Yanagihara Akitoshi , Umesaki Tetsuya , Yamaguchi Ou , Mouri Atsuto , Kawasaki Tomonori , Yasuda Masanori , Kobayashi Kunihiko , Sakaguchi Hirozo , Kuji Ichiei , Kagamu Hiroshi 
Published: August 2021

AbstractBackground2‐deoxy‐2‐[fluorine‐18] fluoro‐d‐glucose (18F‐FDG) positron emission tomography (18F‐FDG‐PET) is a convenient modality to assess the metabolic activity within tumor cells. However, there is no consensus regarding the relationship between 18F‐FDG uptake and the immune environment in thymic epithelial tumors (TETs). We conducted a clinicopathological study to elucidate the relationship between 18F‐FDG uptake and programmed death ligands 1 and 2 (PD‐L1/PD‐L2) expression in patients with TETs. Methods: A total of 108 patients with histologically confirmed TETs classified as thymomas or thymic carcinomas who underwent surgical resection or biopsy or needle biopsy and 18F‐FDG PET before any treatment between August 2007 and March 2020 were enrolled in this study. Tumor specimens underwent immunohistochemical staining for PD‐L1, PD‐L2, GLUT1, HIF‐1α, VEGFR2, VEGF‐C, and β2 adrenergic receptor. Results: High uptakes of SUVmax, SUVmean, MTV, and TLG were identified in 28 (25.9%), 61 (56.5%), 55 (50.9%), and 55 (50.9%) of 108 patients, respectively. High uptake of SUVmax significantly correlated with PS (performance status) of 1–2, thymic carcinoma, and advanced stage, and SUVmax on 18F‐FDG uptake displayed a close association with PD‐L1 and PD‐L2 expressions, but not with MTV and TLG. Our analysis revealed that SUVmax was identified as being significant relationship for positive PD‐L1/PD‐L2 expression. GLUT1, HIF‐1α, and VEGFR2 were significantly associated with the expression of PD‐L1/PD‐L2 from the biological viewpoint.Conclusion18F‐FDG accumulation was closely associated with the expression of PD‐L1/PD‐L2, which, in turn, was correlated with glucose metabolism and hypoxia. PD‐L1/PD‐L2 could affect the glucose metabolism and hypoxia in thymic tumor cells.
Upregulation of circ‐FBL promotes myogenic proliferation in myasthenia gravis by regulation of miR‐133/PAX7
Authors: Lai Xiaoyin , Bi Zhuajin , Yang Xuelian , Hu Rongguo , Wang Lu , Jin Mingming , Li Longxuan , Bu Bitao 
Published: August 2021

AbstractMyasthenia gravis (MG) is a disease involving neuromuscular transmission that causes fatigue of skeletal muscles and fluctuating weakness. It has been shown that impairment of myogenic differentiation and myofiber maturation may be the underlying cause of MG. In this study, we detected the abnormal expression of circular RNA (circRNA) using next‐generation sequencing in patients with MG. We then investigated the regulatory mechanism and the relationship among circRNA, microRNA, and messenger RNA using quantitative reverse‐transcription polymerase chain reaction, bioinformatics analysis, and luciferase report analysis. The expression of inflammatory cytokines and regulatory T lymphocytes was shown to be increased. Circ‐FBL was significantly increased in MG patients. Bioinformatics and luciferase report analyses confirmed that miR‐133 and PAX7 were the downstream targets of circ‐FBL. Overexpression of circ‐FBL promoted myoblast proliferation by regulation of miR‐133/PAX7. Taken together, our study showed that upregulation of circ‐FBL promoted myogenic proliferation in patients with MG by regulating miR‐133/PAX7.
Two rare cases of bronchus‐associated lymphoid tissue lymphoma successfully treated with rituximab‐bendamustine
Authors: Panitz Nydia , Gerhardt Kristin , Becker Cornelia , Schleife Hendrikje , Bach Enrica , Opitz Sabine , Schaudinn Alexander , Platzbecker Uwe , Kayser Sabine 
Published: August 2021

AbstractBALT lymphoma is a rare B‐NHL with a favorable prognosis. We here report on two patients with nonspecific symptoms: one showed as major symptom severe thrombocytopenia and the other dyspnea and dry cough, thereby suggesting an inflammatory focus in the lungs. There is no standard of care established yet. Both patients were successfully treated with rituximab and bendamustine. Thus, combined immunochemotherapy should be considered as first‐line therapy as in other MALT lymphomas, if the treatment/eradication of an underlying chronic inflammatory disorder/trigger factor can be excluded.
A rare case of bifocal, extramedullary and hyposecretory relapse of multiple myeloma
Authors: Minarik Jiri , Szotkowski Tomas , Hrbek Jan , Krhovska Petra , Buriankova Eva , Proskova Jitka , Pika Tomas , Bacovsky Jaroslav 
Published: August 2021

AbstractWe present a rare extramedullary, bifocal, and hyposecretory manifestation of relapsed MM that could be mistaken for an infection. We stress the importance of complex evaluation including serum, urine, and bone marrow assessment and whole‐body imaging.
Intrapulmonary lymph nodes masquerading as pleural metastasis
Authors: Matsuda Yasuhiko , Okazaki Akihito , Yachi Tsuyoshi , Shibata Kazuhiko 
Published: August 2021

AbstractIntrapulmonary lymph nodes (IPLNs) are a frequent finding of computed tomography for lung cancer and can grow without malignant findings. Linear densities extending from the nodules are a characteristic of IPLNs.
CNS tuberculoma in patient with tetralogy of fallot: A case report
Authors: Chamlagain Rajan , Shah Sangam , Rijal Bijay , Dhital Roman , Kandel Bipin , Sharma Paudel Basanta 
Published: August 2021

AbstractWe report this case to focus on the importance of early diagnosis, challenges to reach the diagnosis in a low‐resource setting, and management that may result in a better prognosis of the patients.
Strangulated obturator hernia: Report of two cases
Authors: Kardoun Nizar , Hadrich Zied , Masmoudi Abderrahmen , Harbi Houssem , Boujelben Salah , Mzali Rafik 
Published: August 2021

AbstractObturator hernia is a rare condition, which can be life‐threatening if misdiagnosed. We must consider the diagnosis in case of a bowel obstruction especially in elderly women.
Disseminated Nocardia Paucivorans in an immunocompetent patient: A case report and literature review
Authors: Samannodi Mohammed 
Published: August 2021

AbstractNocardia paucivorans can cause disseminated infection in immunocompetent hosts in rare occasions. Nocardia paucivorans is usually susceptible to many antibiotics including Trimethoprim/Sulfamethoxazole. Duration of treatment is usually 6–12 months.
Access to Indole‐Fused Benzannulated Medium‐Sized Rings through a Gold(I)‐Catalyzed Cascade Cyclization of Azido‐Alkynes
Authors: Greiner Luca C. , Inuki Shinsuke , Arichi Norihito , Oishi Shinya , Suzuki Rikito , Iwai Tomohiro , Sawamura Masaya , Hashmi A. Stephen K. , Ohno Hiroaki 
Published: August 2021

AbstractInvited for the cover of this issue is Hiroaki Ohno and co‐workers at Kyoto University, Hokkaido University, and Heidelberg University. The image depicts a golden compass that guides the adventurer's way in an unknown chemical space. Read the full text of the article at 10.1002/chem.202101824.
Non‐conventional Behavior of a 2,1‐Benzazaphosphole: Heterodiene or Hidden Phosphinidene?
Authors: Kremláček Vít , Kertész Erik , Benkő Zoltán , Erben Milan , Jirásko Robert , Růžička Aleš , Jambor Roman , Dostál Libor 
Published: August 2021

AbstractInvited for the cover of this issue are Zoltán Benkő, Libor Dostál and co‐workers at the University of Pardubice and the Budapest University of Technology and Economics. The image depicts signs for the two different pathways representing the two differing reaction types which were clearly observed for 2,1‐benzazaphosphole. Read the full text of the article at 10.1002/chem.202101686.
Highly Sensitive Fluorescent pH Microsensors Based on the Ratiometric Dye Pyranine Immobilized on Silica Microparticles
Authors: Chandra Anil , Prasad Saumya , Iuele Helena , Colella Francesco , Rizzo Riccardo , D'Amone Eliana , Gigli Giuseppe , del Mercato Loretta L. 
Published: August 2021

AbstractInvited for the cover of this issue are Anil Chandra, Loretta L. del Mercato and co‐workers at the Institute of Nanotechnology of National Research Council and the University of Salento. The image depicts how negatively charged pH‐sensitive pyranine (HPTS) molecules were successfully immobilized on silica microparticles (SMPs) without compromising the molecules′ pH sensitivity. These resulting sensors can be used to measure pH in vitro and in vivo due to the cytocompatibility of HPTS molecules and SMPs. Read the full text of the article at 10.1002/chem.202101568.
Al2O3 and CuO nanoparticles as promising additives to improve the properties of KCl‐polymer mud: An experimental investigation
Authors: Mahmoud Omar , Mady Ahmed , Dahab Abdel Sattar , Aftab Adnan 
Published: August 2021

AbstractDrilling fluid technology is one of the most targeted and developed technologies worldwide due to the increasing demand for deeper drilling and more complicated wells. Several studies have shown numerous improvements in the mud characteristics when using nanoparticles (NPs) as additives. This study aims at examining the influence of using aluminium oxide (Al2O3) and copper oxide (CuO) NPs on the characteristics of KCl‐polymer mud, which is mainly used while drilling shaly formations. Two sizes of Al2O3‐NPs (15 and 40 nm) in addition to CuO‐NPs (40 nm) were investigated at different concentrations (0.1, 0.3, 0.5, 0.7, and 1.0 wt.%) using a standard viscometer and API filter press. Zeta potential (ζ‐potential), scanning electron microscopy (SEM), and energy‐dispersive X‐ray spectroscopy (EDX) were used to elaborate the effect of NPs on the properties of NPs‐based KCl‐polymer mud. The results showed higher potential of Al2O3‐NPs and CuO‐NPs to enhance the mud properties when used at small concentrations of 0.3–0.5 wt.%. Furthermore, NPs were found to play a key role in building efficient filter cakes with time during filtration (up to 90 min). Moreover, smoother surface morphologies and less porous structures of filter cakes were observed when using NPs with some agglomeration of CuO‐NPs due to higher density. The Herschel‐Bulkley model was found to provide a better fitting of the rheological data of NPs‐based KCl‐polymer mud than the Bingham plastic model. This approach would be able to virtually overcome any shale issue encountered by proactively plugging nanopores while inhibiting the water absorption in shale formations.
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
Authors: Reiswich Viktor , Gorbokon Natalia , Luebke Andreas M , Burandt Eike , Menz Anne , Kluth Martina , Hube‐Magg Claudia , Wittmer Corinna , Weidemann Sören , Fraune Christoph , Möller Katharina , Lebok Patrick , Sauter Guido , Simon Ronald , Uhlig Ria , Wilczak Waldemar , Jacobsen Frank , Minner Sarah , Krech Rainer , Bernreuther Christian , Marx Andreas , Steurer Stefan , Clauditz Till , Krech Till 
Published: August 2021

AbstractPlacental alkaline phosphatase (PLAP) is commonly expressed at high levels in testicular germ cell tumors. PLAP immunohistochemistry (IHC) is thus often used to confirm this diagnosis, especially in cases of putative metastasis. However, other tumors can also express PLAP. To comprehensively determine PLAP expression in normal and tumor tissue, a tissue microarray containing 16,166 samples from 131 different tumor types and subtypes as well as 608 samples from 76 different normal tissue types was analyzed by IHC. Moderate to strong PLAP positivity was found in 27 (21%) of 131 different tumor types including seminoma (96%), embryonal carcinoma (85%), and yolk sac tumors of the testis (56%); endometrioid carcinoma of the endometrium (28%) and the ovary (20%); gastric adenocarcinoma (22%); serous carcinoma (not otherwise specified) of the ovary (17%) and the uterus (11%); adenocarcinoma of the ampulla of Vater (15%); carcinosarcoma of the ovary (11%) and the uterus (8%); esophageal adenocarcinoma (10%); invasive urothelial carcinoma (4%); cholangiocarcinoma (2%); and adenocarcinoma of the lung (1%). Low‐level PLAP immunostaining, often involving only a small fraction of tumor cells, was seen in 21 additional tumor entities. The clinical significance of PLAP expression may vary between tumor types as high PLAP expression was linked to advanced pathological tumor stage (p = 0.0086), nodal metastasis (p = 0.0085), and lymphatic (p = 0.0007) and blood vessel invasion (p = 0.0222) in colorectal cancer, but to low pathological tumor stage in endometrial cancer (p = 0.0043). In conclusion, our data identify several tumor entities that can show PLAP expression at comparable levels to testicular germ cell tumors. These tumor entities need to be considered in cases of PLAP‐positive metastasis. Low‐level PLAP expression can be found in various other tumor entities and should generally not be viewed as a strong argument for germ cell neoplasia.
Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum
Authors: Reyes‐Pinto Rosana , Ferrán José L. , Vega‐Zuniga Tomas , González‐Cabrera Cristian , Luksch Harald , Mpodozis Jorge , Puelles Luis , Marín Gonzalo J. 
Published: August 2021

AbstractNeurons can change their classical neurotransmitters during ontogeny, sometimes going through stages of dual release. Here, we explored the development of the neurotransmitter identity of neurons of the avian nucleus isthmi parvocellularis (Ipc), whose axon terminals are retinotopically arranged in the optic tectum (TeO) and exert a focal gating effect upon the ascending transmission of retinal inputs. Although cholinergic and glutamatergic markers are both found in Ipc neurons and terminals of adult pigeons and chicks, the mRNA expression of the vesicular acetylcholine transporter, VAChT, is weak or absent. To explore how the Ipc neurotransmitter identity is established during ontogeny, we analyzed the expression of mRNAs coding for cholinergic (ChAT, VAChT, and CHT) and glutamatergic (VGluT2 and VGluT3) markers in chick embryos at different developmental stages. We found that between E12 and E18, Ipc neurons expressed all cholinergic mRNAs and also VGluT2 mRNA; however, from E16 through posthatch stages, VAChT mRNA expression was specifically diminished. Our ex vivo deposits of tracer crystals and intracellular filling experiments revealed that Ipc axons exhibit a mature paintbrush morphology late in development, experiencing marked morphological transformations during the period of presumptive dual vesicular transmitter release. Additionally, although ChAT protein immunoassays increasingly label the growing Ipc axon, this labeling was consistently restricted to sparse portions of the terminal branches. Combined, these results suggest that the synthesis of glutamate and acetylcholine, and their vesicular release, is complexly linked to the developmental processes of branching, growing and remodeling of these unique axons.
End of Life of Biodegradable Plastics: Composting versus Re/Upcycling
Authors: Gioia Claudio , Giacobazzi Greta , Vannini Micaela , Totaro Grazia , Sisti Laura , Colonna Martino , Marchese Paola , Celli Annamaria 
Published: August 2021

AbstractNowadays the issues related to the end of life of traditional plastics are very urgent due to the important pollution problems that plastics have caused. Biodegradable plastics can help to try to mitigate these problems, but even bioplastics need much attention to carefully evaluate the different options for plastic waste disposal. In this Minireview, three different end‐of‐life scenarios (composting, recycling, and upcycling) were evaluated in terms of literature review. As a result, the ability of bioplastics to be biodegraded by composting has been related to physical variables and materials characteristics. Hence, it is possible to deduce that the process is mature enough to be a good way to minimize bioplastic waste and valorize it for the production of a fertilizer. Recycling and upcycling options, which could open up many interesting new scenarios for the production of high‐value materials, are less studied. Research in this area can be strongly encouraged.
Donor Bandgap Engineering without Sacrificing the Reduction Ability of Photogenerated Electrons in Crystalline Carbon Nitride
Authors: Zhang Guoqiang , Xu Yangsen , Mi Hongwei , Zhang Peixin , Li Haowen , Lu Yujuan 
Published: August 2021

AbstractCrystalline carbon nitride (CCN) with a light response up to 700 nm has been seldom reported but is significant for the artificial photocatalysis. In this study, it is proposed that, unlike acceptors, introducing donors can effectively narrow the bandgap without sacrificing the reduction ability of photogenerated electrons, which is more advantageous to photocatalytic reduction reactions. Hence, a series of heptazine‐based K+‐implanted CCN (KCN) with a narrow bandgap (2.87–1.86 eV) are constructed by copolymerization of pyrimidine donors. The optimized photocatalysts can extend the light response to 700 nm and account for approximately 122‐ and 33‐fold enhancements in H2production (λ>500 nm) in comparison to CN and KCN, respectively. The apparent quantum efficiency (AQE) can reach 8.2 % at 500 nm and is comparable to the top‐level CN‐ and CCN‐ based materials. Its photoactive wavelength has significant advantages over previously reported CCN‐based photocatalysts. This method offers a universal donor bandgap engineering strategy towards photocatalytic reduction reactions.
Productivity modifies the effects of fire severity on understory diversity
Authors: Brodie Emily G. , Miller Jesse E.D. , Safford Hugh D. 
Published: August 2021

AbstractHigh severity fire may promote or reduce plant understory diversity in forests. However, few empirical studies have tested long‐standing theoretical predictions that productivity may help to explain observed variation in post‐fire plant diversity. Support for the influence of productivity on disturbance‐diversity relationships is found predominantly in experimental grasslands, while tests over large areas with natural disturbance and productivity gradients are few and have yielded inconsistent results. Here, we measured the response of post‐fire understory plant diversity to natural gradients of fire severity and productivity in a large‐scale observational study in California’s subalpine forests. We found that plant species richness increased with increasing fire severity and that this trend was stronger at high productivity. We used plant traits to investigate whether release from competition might contribute to increasing diversity and found that short‐lived and far‐dispersing species benefited more from high severity fire than their long‐lived and near‐dispersing counterparts. For far‐dispersing species only, the benefit from high severity fire was stronger in high productivity plots where unburned species richness was lowest. Our results support theoretical connections between fire severity, productivity and plant communities that are key to predicting the consequences of increasing fire severity and frequency on diversity in the coming decades.
Two‐year outcomes from the MitrAl ValvE RepaIr Clinical (MAVERIC) trial: a novel percutaneous treatment of functional mitral regurgitation
Authors: Patterson Tiffany , Gregson John , Erglis Andrejs , Joseph Jubin , Rajani Ronak , Wilson Karen , Prendergast Bernard , Worthley Stephen , Hildick‐Smith David , Rafter Tony , Whelan Alan , De Marco Federico , Horrigan Mark , Redwood Simon R. 
Published: August 2021

AbstractAimsWe report the 2‐year outcomes of the MitrAl ValvE RepaIr Clinical (MAVERIC) trial. Functional mitral regurgitation (FMR) is associated with poor outcomes for which there remains an unmet clinical need. ARTO is a transcatheter annular reduction device for the treatment of FMR and an emerging alternative for patients at high surgical risk. The MAVERIC trial was designed to evaluate the safety and performance of the ARTO system in FMR and heart failure (HF).Methods and resultsMAVERIC is an international multicentre, prospective, single arm study enrolling patients with FMR grade ≥ 2, New York Heart Association (NYHA) class ≥II symptoms despite maximal medical therapy. Patients were excluded if they had significant structural mitral valve abnormality or life expectancy <1 year. The primary outcome measures were a composite safety outcome and efficacy defined as mitral regurgitation (MR) reduction 30 days post‐procedure. Secondary outcome measures included safety, change in MR grade, NYHA class and hospitalization for HF at 2 years. Forty‐five patients were enrolled. The composite safety outcome was met (2/45 adverse events at 30 days) and no device‐related deaths occurred at 2‐year follow‐up. A sustained reduction in MR [grade < 2: 21/31 (68%) vs. 31/31(0%); P < 0.0001], left ventricular end‐diastolic volume index (90.0 ± 30 vs. 106 ± 26 mL/m2; P = 0.004) and anteroposterior diameter (35.5 ± 4.7 vs. 41.4 ± 4.6 mm; P < 0.0001) was seen at 2 years compared to baseline. Progressive symptomatic improvement [NYHA class ≤II: 27/34 (80%) vs. 12/34 (36%); P < 0.0001] and a reduction in HF hospitalizations (19.8% 2 years post vs. 52.3% 2 years prior; P < 0.001) were seen at 2 years compared to baseline.ConclusionsThe ARTO system is a safe and effective treatment for FMR with reductions in left ventricular end‐diastolic volumes sustained to 2 years.