bluuebunny/crossref_metadata_2025_split huggingface dataset:
First modern Russian plasma-derived coagulation factor VIII concentrate (Eytoplasm): Results of clinical study of pharmacokinetics, efficacy and safety
Authors: Zorenko V. Yu. , Makhmudova A. D. , Schiller E. E. , Polyanskaya T. Yu. , Berger I. V. , Juraeva N. T. , Korolyova A. A. , Mamatov S. M. , Narbekov T. O. 
Published: December 2024

Introduction. Replacement therapy with coagulation factor VIII concentrates remains the standard of care for patients with hemophilia A. In 2023, the drug Eytoplasm, the first modern plasma-derived coagulation factor VIII concentrate developed in the Russian Federation, was authorized for medical use in the Russian Federation.Aim: to study the efficacy, safety, immunogenicity, and pharmacokinetic properties of Eytoplasm.Methods. A multicenter, prospective, open-label clinical trial was conducted in 55 patients over 12 years of age with severe hemophilia A who had previously received treatment with coagulation factor VIII concentrates (at least 150 exposure days). All patients received the drug for prophylactic treatment 2–3 times a week; the treatment duration was 6 months (at least 50 exposure days). In addition, the drug was used to treat bleeding. Ten patients underwent 10 surgical interventions (2 major and 8 minor). Pharmacokinetic parameters were determined after the first administration of the drug to patients and after 6 months of therapy.Results. Eytoplasm pharmacokinetics properties are comparable with other plasma-derived coagulation factor VIII concentrates. No bleeding was recorded in 75.9% of patients. In 92.3 % of patients, a single administration of the drug was sufficient to stop an episode of bleeding. In all participants who completed the study, the residual activity of coagulation factor VIII 48–72 hours after drug administration was at least 1 %. Positive dynamics of APTT was showed during the study. Serious adverse events, allergic reactions, thrombotic and thromboembolic complications were absent in patients. In 3 patients, 4 adverse events associated with the use of the drug were registered: 2 cases of increased serum concentration of direct bilirubin and 2 cases of headache. An inhibitor to coagulation factor VIII was not detected in any patient. In none of the patients who did not have antibodies to parvovirus B19 before the first dose of Eytoplasm, antibodies were detected after 6 months of therapy.Conclusion. Eytoplasm is an effective option for the prevention and treatment of bleeding, and during surgical interventions, including major ones, in patients with hemophilia A. The drug has a favorable safety profi le; its use was not associated with the formation of inhibitory antibodies, allergic reactions, thrombotic and thromboembolic complications.
Treatment of refractory and recurrent T-lymphoblastic lymphomas from progenitor cells in children and adolescents: current problem state and future perspectives
Authors: Pavlova T. Yu. , Valiev T. T. , Varfolomeeva S. R. 
Published: December 2024

Introduction. Despite the successes achieved in the treatment of lymphoblastic lymphomas from progenitor cells (LBL), an important task in improving survival rates in the group of patients with T-cell lymphoblastic lymphomas (T-LBL) remains. The group of special unfavorable prognosis consists of patients with relapses and refractory forms (r/r) of T-LBL.Aim: to present a literature review on the use of targeted and immune drugs, as well as cellular and transplant methods in the treatment of r/r T-LBL.Main findings. Modern clinical onco-hematology has a broad spectrum of methods for the treatment of r/r T-LBL, including intensive chemotherapy, targeted, transplant and CAR-T technologies, but even a combination of these methods, currently, does not make it possible to achieve optimistic results in this prognostically unfavorable group of patients. It is possible that the creation of targeted drugs focused on signaling pathways (NOTCH, PI3K/ACT/mTOR, JAK/STAT and MAPK) with modern therapeutic potential could improve patient survival rates.
Efficacy of anti-CD19 CAR-T therapy after bispecific monoclonal antibody (CD19/CD3) therapy in a patient with relapsed Ph-positive acute lymphoblastic leukemia with a massive extramedullary component
Authors: Aleshina O. A. , Akezheva K. A. , Eroshenkov D. Yu. , Vasilyeva A. N. , Shchekina A. E. , Nalbandyan S. A. , Galstyan G. M. , Bogolyubova A. V. , Galtseva I. V. , Kovrigina A. M. , Parovichnikova E. N. 
Published: December 2024

Introduction. Patients with relapsed/refractory (r/r) Ph-positive acute lymphoblastic leukemia (ALL) have a poor prognosis and limited treatment options. New promising immunotherapies using CAR T cells or monoclonal antibodies (blinatumomab, inotuzumab/ozogamicin) in combination with tyrosine kinase inhibitors are being used for this group of patients. However, long-term results have not been studied when relapse or refractoriness develops after the use of one of these methods.Aim: to present a clinical observation of the use of anti-CD19 CAR T therapy after blinatumomab therapy in a patient with a relapsed course of Ph-positive acute lymphoblastic leukemia.Main findings. A 28-year-old patient was first diagnosed with Ph-positive B-ALL (transcript p210) in 2014. In the 1st line of treatment he was treated with therapy according to the protocol ‘ALL-2009’ with imatinib and allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, 2 months later the first molecular relapse was detected, and imatinib was replaced by dasatinib. In November 2016, a second relapse was diagnosed. In 2017, a third relapse with testicular involvement and T315I mutation was diagnosed, and therapy with ponatinib was initiated. In 2022, a 4th medullary relapse developed, and therapy with blinatumomab (5 courses) in combination with ponatinib was performed. After the 5th course of therapy, the appearance of leukaemides was noted, and asciminib was added to the therapy. However, no clinical effect was noted. The patient was treated with anti-CD19 CAR T therapy. A complete response to CAR T-cell therapy was confirmed on day 28 after CAR T administration. Further follow-up, over the course of one year, demonstrated stable clinical response and persistence of CD3-positive CAR T-cells. This case report of anti-CD19 CAR T cell therapy in a patient with CD19-positive combined relapse with massive extramedullary component after blinatumomab therapy demonstrated long-term efficacy with a 1-year follow-up.
Tingkat Pengetahuan tentang Xerostomia pada Pasien Lansia di Puskesmas
Authors: Ariani Dwi , Az Zahra Septiana A. 
Published: December 2024

Abstract: Xerostomia is defined as a subjective complaint of dry mouth associated with salivary gland hypofunction, mostly found among elderly. This study aimed to obtain the level of knowledge about xerostomia in elderly patients at Pasir Jaya Health Center, Cikupa, Tangerang. This was a descriptive study with a cross-sectional design using a questionnaire method (google form) consisting of an overview of the sociodemographic and health characteristics of respondents, Abbreviated Mental Test (AMT), and Summated Xerostomia Inventory Indonesia Version (SXI-ID) instruments. Respondents' knowledge was classified into three-level scales, namely good, fair and low. Data were processed with SPSS software. The results obtained 106 elderly patients as respondents. Based on the distributed questionnaires, 56 respondents (53%) had good level of knowledge and 50 respondents (47%) had moderate level of knowledge. Respondents with systemic condition as many as 76 patients (71.70%), xerogenic drug consumption 76 patients (71.70%), and status as smoker 28 patients (26.42%). In conclusion, among elderly patients at Pasir Jaya Health Center, Cikupa, Tangerang, the level of knowledge about xerostomia is classified as good and fair. The most frequent factors related to xerostomia are systemic condition and xerogenic drug consumption.
Keywords: level of knowledge; xerostomia; elderly

Abstrak: Xerostomia di definisikan sebagai keluhan subjektif dari mulut kering yang berhubungan dengan hipofungsi kelenjar saliva, terutama dijumpai pada lanjut usia (lansia). Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan tentang xerostomia pada pasien lansia di Puskesmas Pasir Jaya Kecamatan Cikupa Kabupaten Tangerang. Jenis penelitian ialah deskriptif edngan desain potong lintang menggunakan metode kuesioner (google form) yang terdiri dari gambaran umum karakteristik sosiodemografi dan kesehatan responden, Instrumen Abbreviated Mental Test (AMT), dan Summated Xerostomia Inventory Indonesia Version (SXI-ID). Pengetahuan responden digolongkan dalam skala tiga tingkat, yaitu baik, cukup dan rendah. Data diolah dengan software SPSS. Hasil penelitian mendapatkan 106 pasien lansia sebagai responden. Berdasarkan kuesioner yang didistribusikan sebanyak 56 responden (53%) dengan tingkat pengetahuan baik dan 50 responden (47%) dengan tingkat pengetahuan cukup. Responden dengan kondisi sistemik sebanyak 76 orang (71,70%), minum obat xerogenik 76 orang (71,70%), dan status perokok saat ini 28 orang (26,42%). Simpulan penelitian ini ialah pengetahuan mengenai xerostomia pada pasien lansia di Puskesmas Pasir Jaya Kecamatan Cikupa Kabupaten Tangerang, tergolong baik dan cukup. Faktor yang paling sering menyebabkan terjadinya xerostomia pada pasien lansia yaitu kondisi sistemik dan konsumsi obat xerogenik.
Kata kunci: tingkat pengetahuan; xerostomia; lanjut usia
Leadership Commitment to Corporate Social Responsibility Sustainability and Project Performance in the Mining Industry in Kenya: A Case of Tata Chemicals, Magadi
Authors: Opondo Edward , Nderitu Wanjiru 
Published: December 2024

Corporate social responsibility is a self-regulating business model that helps a company to be socially accountable to itself, its stakeholders and public. The objective of the study was to examine the effect of Leadership commitment to CSR sustainability performance in the mining industry in Kenya. Different theories and literature relating to the study were reviewed and the emerging knowledge gap identified. The research was conducted in the mining industry specifically within Tata Chemicals Magadi Limited (TCML). The target population was 300 respondents from different departments including marketing and supply chain (internally) and externally the population included women and young people. The researcher used stratified random sampling. From the possible 300 target population, stratified random sampling was employed to select a total of 72 sample population. This is 24% of the total population. The method used for data collection was quantitative design where a structured questionnaire was used to get the views. Both qualitative and quantitative process was used to analyze the data that was collected and compute the information using Statistical Package for Social Sciences (SPSS). The findings were presented to the panelists by use of power point presentation. The findings demonstrated that the R square value of the model was 0.399 indicating that 39.9% of the project performance is influenced by leadership motivation. The study therefore, concluded that leadership commitment is important to organization in terms of its influence on the implementation of CSR but its consistency with project performance has yet to be supported by the study. The study recommends that companies should focus on commitment to its employees as this is vital in achieving and retaining competitive advantage. The study also recommends company should select project members carefully to enhance its performance. It also endorses that a similar study to be conducted on the influence of CSR initiatives on project performance on other industries.
IMPROVEMENT OF GROWTH, PHYSIOLOGICAL AND BIOCHEMICAL TRAITS OF SUNFLOWER BY IAA AND BAP UNDER SALINITY STRESS in vitro
Authors: Safa  H. Kh.  , S. I. Neamah  
Published: December 2024

This study was established to investigate the ability of the sunflower callus plant (Helianthus annuus L.) to tolerate salinity stress for two levels of NaCl (0 and 80 mM), three concentrations of IAA (0, 1.0, and 2.0 mg l-1), and BAP (0, 1.0, and 2.0 mg l-1) in lab conditions. Calli cultures were induced from the cotyledon of H. annuus L. cultured in an appropriate combination of growth regulators 2,4-D and kintein. The salinity results exhibited negative effects in most of the study indications, which can be revealed by a significant increase in sodium content (Na+), hydrogen peroxide (H2O2) and malondialdehde content (MDA). While, the decrease in the study indications such as fresh weight (FW), dry weights (DW), relative water content (RWC), potassium content (K+), sodium/ potassium ratio (Na+/K+), superoxide dismutase (SOD), and catalase (CAT) enzymes activity. The experiment revealed a positive effect for the exogenous growth regulators IAA and BAP in reducing the harmful effects of salinity stress on calli cultures. The nominated regulators succeeded in reducing the harmful effects of salinity stress, where the FW, DW, RFW, browning density (BI), RWC, K+, Na+/K+, SOD, and CAT enzymes activity. However, the exogenous growth regulators reduced the negative effect for each of Na+, H2O2, and MDA under the salinity stress.
EFFECT OF MINERAL COMPOSITION ON SEQUENTIAL EXTRACT OF LEAD AND CADMIUM IN SOME IRAQI SOILS
Authors: Abdul Baqi D.S. Al Maamouri  , Salwa H. K. Al Shamary  
Published: December 2024

This study was aimed to find out the effect of different soil components of some Iraqi soils under different climatic conditions and different parent materials on the adsorption of lead and cadmium. Soil samples were collected from four governorates (Dohuk, Wasit, Salah al-Din, and Basra), with three sites in each governorate, and two depths (0-30 and 31-60) cm. A chemical analysis of the soil were carried out to determine the amount of organic matter, carbonate minerals, total and crystallized free iron oxides. Results showed that the values ​​of and soluble and exchangeable lead binded with carbonate minerals, organic matter, oxides, and clay fraction in rates ranging between (0.27-1.04), (0.83-1.51), (18.81-41.58), (2.31-21.95), (3.93-23.75), and (5.65-5). 67.83)% respectively of the soil content and the values ​​of the coefficient of determination R2 (0.86, 0.16, 0.72, 0.79, 0.40, and 0.69), respectively. As for the cadmium element, the results showed that its values ​​were (0.49-1.66), (1.13-2.47), (40.24-79.51), (0.24-7.98), (3.25-36.76) and (6.74-38.24)% for the soluble ,exchangeable and binded with carbonate minerals, organic matter, oxides, and clay fraction respectively.
GENETIC PARAMETERS OF GROWTH, CARCASS, AND LAYING TRAITS IN TWO LINES OF UKRAINIAN QUAIL
Authors: Jameela Hairan Salih  
Published: December 2024

The estimation of genetic parameters of certain productive characters in different lines of quail is very important to make a breeding schedule for such lines of quail in the future. This study was carried out for three generations to estimate the response to selection, selection deferential, genetic, and phenotypic correlation between studied traits (growth and laying performance) and heritability estimates in two lines of Ukrainian quail (Coturnix coturnix coturnix). A total of 120 Ukrainian quails from ) 500 ( quail birds (base population), were

selected as parent generation for both lines and also 120 offspring birds specified for the third generation. The selection was based on body weight which was carried out on the 20th day of age. The results showed that the selection can improve breast weight, leg weight, carcass%, and live body weight in both lines. However, the realized heritability has moderate values for 42-day age body weight for both lines; but the dark line recorded a higher genetic correlation between body weight and weight gain compared to the white line. The highest phenotypic correlation estimates between body weight and egg weight were recorded for the white line; in addition, the same line receded better estimates for the studied genetic parameters in all other studied characteristics. It could be concluded that the selection based on the genetic parameters for growth and laying traits was effective for improving it through the three generations.
EFFECT OF SOME ESSENTIAL OIL AND ORGANIC ACIDS ON BLOOD PICTURE , LIPID PROFILE AND INTESTINAL HEALTH IN BROILER CHICKENS
Authors: Saad M. H.  , S. S. Hameed  , A. J. Ali  
Published: December 2024

The objectire of the present study was to investigate the effect of nutritional additive of associated phytogenic P.E.P. and organic acids supplemented in drinking water on their, blood parameters, lipid profile and intestinal histomorphology in broilers. For this purpose, 240 chicks (Ross-308) one-day old were divided randomly into 6 equal groups each group 40 chicks as follow. G1supplemented with( 0.015 cc Essential Oil (EO) with Aromatic Oil (AO) 0.5cc/L) , G2 add (AO 2cc/L) ,G3 was mix (EO 0.06cc with AO 1,5cc/L) ,G4(0.03 EO with1cc AO/L ,G5 0,12cc EO /L and control (G6) group was fed the basal diet ,the results of blood parameters were indicated significant (P≤0.05) increase in amount of WBC,RBCs, hemoglobin and PCV in groups 3, 4 and 5 compared with the control , also revealed significant increased (P≤0.05) of HDL-cholesterol concentration in G3 and G4 but decreased in triglyceride, total and low density lipid concentrations were influenced by the dietary treatments in G4,3,2 and VLDL in G3 and 5.also exposed significant (P≤0.05)increased in the height and thickness of villus and crypt depth in all parts of small intestine of G3,G4 and G5 compare to the control group. In conclusion the mix Essential Oil and Aromatic Oil supplementation to the broiler diet improve blood picture (RBCs .WBCs,Hb and PCV) and enhanced with maintenance the function of the small intestine .
ANALYZING THE CHARACTERISTICS AND BIOLOGICAL ACTIVITIES OF METHANOLIC EXTRACTS FROM STACHYS BYZANTINE LEAVES
Authors: Ali Q. Khazaal  , Zainab F. Mahmood  , Sanaa A. Hammood  
Published: December 2024

This study was aimed to examine the suppressive effects of Stachys byzantine leaf methanolic extracts on cancer cell lines and pathogenic microbes. Five concentrations of S. byzantine methanolic extract, from 25 to 400 µg/ml, were applied to HepG1 and HCT116 cells. S. byzantine methanolic extracts inhibited liver and colon cancer cell viability at different concentrations. The MTT assay results demonstrated that the extract’s IC-50 values for HepG1 were 271.61µg/ml and for HCT116 was 184.86µg/ml. The methanolic extracts obtained from S. byzantine showed antibacterial activity against Gram-negative and Gram-positive bacteria. The extract inhibited Staphylococcus aureus with 15, 20, and 22 mm inhibition zones at 100, 200, and 400 mg/ml, respectively. However, the extract was more effective against Pseudomonas aeruginosa, with inhibitory zones of 30, 30, and 35 mm at 100, 200, and 400 mg/ml respectively. This study indicates that methanolic extracts derived from S. byzantine leaves have anti-cancer and antibacterial properties.
EVALUTION OF MICROBIAL ACTIVITY IN ORGANIC SOLID FRACTION DURING COMPOSTING PROCESS TO BIOFERTILIZER USING COMPOSTING BIN METHODS
Authors: Aseel N. A.  , F. M. Hassan  , N. H. Hyder  
Published: December 2024

The current study aim to evaluating the composting in bins for organic fraction municipal solid waste and tracking the changes in physio-chemical and microbial characteristics such as Temperature, pH, C/N ratio and total viable count, total streptomyces, total coliform and pathogenic microorganisms as total Salmonella Shigella count. Seven treatments were used in research into the quick composting of the organic fraction of municipal solid waste. Two Composting bins contained municipal solid waste (MSW) mixed with animal and poultry manure (3:1), (2:1), waste mixture (2:1:1), and agricultural waste mixed waste. On the first day of composting, the pH was slightly acidic, then increased to alkaline, as EC . Microbiological parameters such as Total viable count are reduced during the thermophilic phase. They increased at the cooling phase , for TSC proliferation occurred in alkaline pH during composting and reached 4.1 CFU/g at maturation in composting bin 7. In conclusion, all composting bins developed a thermophilic phase, all had narrow alkaline pH with EC in some treatments less than 4mS.Cm-1, and C/N reached the desired ratio as stable compost,also microbiological parameters fluctuate with temperature.
EFFECT OF CUTTING KNIVES SPEED AND FEEDING SPEED ON SOME TECHNICAL INDICATORS FOR THE PERFORMANCE OF A LOCALLY MANUFACTURED MACHINE
Authors: S. A. Rawdhan  , W. K. El Helew  , M. A. Mayhoub  , M. M. Moustafa  
Published: December 2024

The experiment was carried out to study some engineering factors for a locally manufactured machine, It cuts agricultural residues to make animal feed , in the workshops of the Agricultural Engineering Department/Faculty of Agriculture/Ain Shams University for the academic year 2021-2022. The effect of three-speed knives cutting speed (1000,1200,1400 rpm) and three-speed feeding speed (0.75,1,1.25 m/s) and the knife cutting angle with two angles (15°.30°) was studied at a knife clearance of 2.5 mm and a moisture content of 5.3%. With an electronic system with sensors to operate the machine and without. Among the technical indicators that have been studied are productivity, cutting power consumption, specific energy, machine operating costs and the thrust power, The results showed that the performance of machine with an electronic system(senser) to a maize chopping machine is better than a maize chopping machine without In terms of specific energy consumption, machine operating costs, at constant clearance of 2.5mm and moisture content 5.3% and an optimum knife speed of 1400 with cutting angle (30°), The maize chopping machine with an electronic system (sensor) of specific energy consumption (0.0027 kw.h/kg), machine operating costs (0.2159 LE/kg) and highest productivity (105,170 kg/hr) at cutting angle (30°).