bluuebunny/crossref_metadata_2025_split huggingface dataset:
LevelMind@JC: Development and evaluation of a community early intervention program for young people in Hong Kong
Authors: Hui Christy L.‐M. , Suen Yi‐Nam , Lam Bess Y.‐H. , Wong Stephanie M.‐Y. , Wong Corine S.‐M. , Lui Simon S.‐Y. , Chan Kai‐Tai , Wong Michael T.‐H. , Chan Sherry K.‐W. , Lee Edwin H.‐M. , Chang Wing‐Chung , Wong Gloria H.‐Y. , Chen Eric Y.‐H. 
Published: December 2021

AbstractAimHong Kong's existing mental health services are inadequate in addressing young people's needs. The LevelMind@JC project established an early intervention platform of community‐based youth‐specific mental health centres involving youth workers, cross‐disciplinary professionals, and young people. The project intends to (1) pilot a community platform that incorporates a youth‐friendly early screening tool with preventative intervention capabilities, (2) set up a state‐of‐the‐art training system for youth mental health workers, (3) establish a community clinical support team and (4) develop a timely evaluation system to monitor the service and evaluate its outcome and cost‐effectiveness against generic youth services.MethodsSix hundred LevelMind@JC service users will be assessed alongside 600 young people visiting generic youth centres and 100 young people in the community. Participants will be matched according to age, gender, years of education, socioeconomic status, and level of distress. Assessments, administered at baseline and at 3, 6 and 12 months, will cover demographic characteristics, psychological distress, quality of life, depressive and anxiety symptoms, functioning, physical health and lifestyle, personality and social measures, cognitive measures and health economics. Mixed‐model ANOVAs will be used to indicate interactions between services and between time points.ConclusionBuilt upon a community‐based support model, LevelMind@JC aims to promote positive mental health in young people through the collaboration of cross‐disciplinary mental health professionals. If efficacy and cost‐effectiveness are established, the project could be scaled up, implicating a wider reach of care. We anticipate its success to be critical in combatting mental health issues stemming from both personal and population‐level stressors.
Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study
Authors: Hamel Raphaël , Lepage Jean‐François , Bernier Pierre‐Michel 
Published: December 2021

AbstractAnterograde interference emerges when two opposite (B → A) or identical tasks (A → A) are learned in close temporal succession, suggesting that interference cannot be fully accounted for by competing memories. Informed by neurobiological evidence, this work tested the hypothesis that interference depends upon the degree of overlap between the neural networks involved in the learning of two tasks. In a fully within‐subject and counterbalanced design, participants (n = 24) took part in two learning sessions where the putative overlap between learning‐specific neural networks was behaviourally manipulated across four conditions by modifying reach direction and the effector used during gradual visuomotor adaptation. The results showed that anterograde interference emerged regardless of memory competition—that is, to a similar extent in the B → A and A → A conditions—and along a gradient as a function of the tasks' similarity. Specifically, learning under similar reaching conditions generated more anterograde interference than learning under dissimilar reaching conditions, suggesting that putatively overlapping neural networks are required to generate interference. Overall, these results indicate that competing memories are not the sole contributor to anterograde interference and suggest that overlapping neural networks between two learning sessions are required to trigger interference. One discussed possibility is that initial learning modifies the properties of its neural networks to constrain further plasticity induction and learning capabilities, therefore causing anterograde interference in a network‐dependent manner. One implication is that learning‐specific neural networks must be maximally dissociated to minimize the interfering influences of previous learning on subsequent learning.
Avoiding the middle‐income trap: The spatial–temporal effects of human capital on regional economic growth in Northeast China
Authors: Yu Tingting , Rong Ah , Hao Feilong 
Published: December 2021

AbstractNortheast China has seen a remarkable transition from rustbelt to economic revival over the past decade. However, promoting sustainable economic growth is a major issue facing Northeast China after entering the middle‐income stage of development. Based on a panel data set of 34 prefecture‐level cities in Northeast China from 2001 to 2018, this paper constructs a human capital index in terms of both quantity (educational capital) and quality (health capital) and uses the generalized method of moments (GMMs) to explore the spatial–temporal effects of human capital on economic growth under the “middle‐income trap.” The results show that a key factor keeping Northeast China in the middle‐income stage is the loss of highly qualified labor and that the previous attribution of the economic downturn to the population exodus is inaccurate. Although the results of this study indicate that the demographic dividend during the demographic transition period has ended in Northeast China and that the associated low‐cost advantage has been lost, the “talent dividend” can still be obtained by improving the level of human capital and thus promoting sustainable economic growth.
Involved fatherhood and the workplace context: A new theoretical approach
Authors: Atkinson Jamie 
Published: December 2021

AbstractThe prevalence of the ideal worker norm and the unwillingness of organizations to acknowledge the transition to fatherhood as a life‐changing event are key factors that continue to inhibit men who pursue greater involvement as parents. This article applies fresh theoretical perspectives that influence the situated agency of new fathers in the workplace. It argues that informal structural conditions at organizational level, specifically the organization of working time (materialized by the influence of organizational rhythms) and the difficulty of articulating a caring masculine identity are factors that significantly contribute to the debate on fathers' reluctance to embrace involved fatherhood. Drawing together the issues discussed above, the article presents a conceptual model, which argues for a recursive relationship between fathers' ability to achieve involved fatherhood and these structural conditions in an organizational context. The article concludes by considering the practical implications of the model for fathers and organizations and presenting a research agenda based on the issues raised.
Percutaneous ablation or minimally invasive partial nephrectomy for cT1a renal masses? A propensity score‐matched analysis
Authors: Bianchi Lorenzo , Chessa Francesco , Piazza Pietro , Ercolino Amelio , Mottaran Angelo , Recenti Dario , Serra Carla , Gaudiano Caterina , Cappelli Alberta , Modestino Francesco , Golfieri Rita , Bertaccini Alessandro , Marcelli Emanuela , Porreca Angelo , Celia Antonio , Schiavina Riccardo 
Published: December 2021

ObjectiveLocal tumor ablation to treat small renal mass is increasing. The aim of the present study was to compare oncologic outcomes among patients with T1 renal mass treated with partial nephrectomy and local tumor ablation.MethodsTo reduce the inherent differences between patients undergoing laparoscopic or robot‐assisted partial nephrectomy (n = 405) and local tumor ablation (n = 137), we used a 1:1 propensity score‐matched analysis. Local tumor ablation consisted of radiofrequency ablation and cryoablation. Disease‐free survival, overall survival and other causes mortality‐free survival rates were estimated using the Kaplan–Meier method. Multivariable logistic regression and competing‐risk regression models were used to identify predictors of complications, recurrence and other causes mortality, respectively.ResultsPartial nephrectomy had higher disease‐free survival estimates, as compared with local tumor ablation (92.8% vs 80.4% at 5 years, P = 0.02), with no significant difference between radiofrequency ablation and cryoablation (P = 0.9). Ablation showed comparable overall survival estimates to partial nephrectomy (91% vs 95.8% at 5 years, P = 0.6). The 5‐year recurrence rates were 7.9% versus 23.8% for patients aged ≤70 years, and 2.5% versus 11.9% for patients aged >70 years treated with partial nephrectomy and ablation, respectively; the 5‐year other causes mortality rates were 0% and 2.2% for patients treated with partial nephrectomy and ablation aged ≤70 years, and 3% versus 10.9% for patients aged >70 years treated with partial nephrectomy and ablation, respectively. At multivariable analysis, ablation was associated with fewer complications (odds ratio 0.41; P = 0.01). At competing risks analysis, age (hazard ratio 0.96) and ablation (hazard ratio 4.56) were independent predictors of disease recurrence (all P ≤ 0.008).ConclusionsLocal tumor ablation showed a higher risk of recurrence and lower risk of complications compared with partial nephrectomy, with comparable overall survival rates.
Masters age football and cardiovascular risk
Authors: Francis Matthew A. , Buckley Thomas , Tofler Alexander R. , Tofler Geoffrey H. 
Published: December 2021

AbstractBackgroundFootball (soccer) is popular among those of Masters age (≥35 years). Although regular exercise improves health, strenuous exercise causes a transient increase in cardiac risk.AimTo gain insight into cardiac risk factors, symptoms, and knowledge, attitudes and beliefs about myocardial infarction (MI), and support for prevention.MethodsA web‐based survey using REDCap was completed by 153 amateur Masters footballers from A grade competition (n = 24), B or lower grade (n = 95) or social games (n = 34) in Sydney, Australia.ResultsParticipants were aged 49.3 ± 7.5 years and primarily male (92.2%), Caucasian (88.9%) and university educated (75.2%). Risk factors included hypercholesterolaemia (37.3%), hypertension (19.6%), smoker (7.8%), overweight (40.5%) or obese (13.1%). One‐fifth (21.6%) reported ≥1 potential cardiac symptom during activity in the prior year, for which one‐quarter (24.2%) sought medical attention. Knowledge of typical MI symptoms was high (>80%) but lower (<40%) for less typical symptoms. Half (49.6%) were not confident to recognise MI in themselves. Half (49.0%) would remain on the field for 5–10 min with chest pain. Only 39.9% were aware that warning signs might precede MI by days. They overestimated survival from cardiac arrest (43%). Participants supported training in automatic external defibrillators (AED) and cardiopulmonary resuscitation (84%), AED at games (85%) and cardiac education (>70%).ConclusionsCardiac risk factors are common In Masters footballers, with one in five experiencing possible cardiac symptoms in the prior year. While gaps exist in knowledge and optimal responses, strong support exists for preventive measures.
Analyses of lambing dates in sheep breeds using von Mises distribution
Authors: Id‐Lahoucine Samir , Schaeffer Larry R. , Cánovas Angela , Casellas Joaquim 
Published: December 2021

AbstractRegular changes in the environment and biological responses generate seasonal patterns in the reproduction in small ruminants. Breeding seasonality is a significant constraint impacting efficiency of lamb production. However, seasonality‐related traits present a special peculiarity from a statistical point of view being circular data (day of year running 1:365). Recently, circular mixed models have been developed on the basis of the von Mises distribution and were applied to analyse lambing day distribution recorded from five major Canadian sheep breeds (Rideau Arcott, Romanov, Dorset, Suffolk and Polypay). In a simulation study, the linear model was not able to capture the variance components simulated under the circular paradigm; however, the von Mises model evidenced its ability to infer the variance components of simulated circular records. Using real data of sheep, mostly negligible variances were observed for additive genetic effect when using a linear model on circular data values. In contrast, when using the von Mises model, genetic variances were different across breeds, and it raises the possibility to delay the peak of reproduction and to change the seasonality of the ewes. However, a large variance was captured by flock‐year effects emphasizing the strong influence of management in lambing seasons for Canadian sheep populations. Finally, the results suggest the potential of using the von Mises model to analyse circular data, and further research is needed for better understand the complexity of this trait and the von Mises models.
Syncytiotrophoblast‐derived extracellular vesicles carry apolipoprotein‐E and affect lipid synthesis of liver cells in vitro
Authors: Tersigni Chiara , Furqan Bari Muhammad , Cai Shijei , Zhang Wei , Kandzija Neva , Buchan Alice , Miranda Fabrizio , Di Simone Nicoletta , Redman Christopher W. , Bastie Claire , Vatish Manu 
Published: December 2021

AbstractIn normal pregnancy, hepatic metabolism adaptation occurs with an increase in lipid biosynthesis. Placental shedding of syncytiotrophoblast‐derived extracellular vesicles (STBEVs) into the maternal circulation constitutes a major signalling mechanism between foetus and mother. We investigated whether STBEVs from normal pregnant women might target liver cells in vitro and induce changes in lipid synthesis. This study was performed at the Nuffield Department of Women's & Reproductive Health, Oxford, UK. STBEVs were obtained by dual‐lobe placental perfusion from 11 normal pregnancies at term. Medium/large and small STBEVs were collected by ultracentrifugation at 10,000g and 150,000g, respectively. STBEVs were analysed by Western blot analysis and flow cytometry for co‐expression of apolipoprotein‐E (apoE) and placental alkaline phosphatase (PLAP). The uptake of STBEVs by liver cells and the effect on lipid metabolism was evaluated using a hepatocarcinoma cell line (HepG2 cells). Data were analysed by one‐way ANOVA and Student's t test. We demonstrated that: (a) STBEVs carry apoE; (b) HepG2 cells take up STBEVs through an apoE‐LDL receptor interaction; (c) STBEV incorporation into HepG2 cells resulted in (i) increased cholesterol release (ELISA); (ii) increased expression of the genes SQLE and FDPS (microarray) involved in cholesterol biosynthesis; (iii) downregulation of the CLOCK gene (microarray and PCR), involved in the circadian negative control of lipid synthesis in liver cells. In conclusion, the placenta may orchestrate the metabolic adaptation of the maternal liver through release of apoE‐positive STBEVs, by increasing lipid synthesis in a circadian‐independent fashion, meeting the nutritional needs of the growing foetus.
IGF2BP3 promotes cell metastasis and is associated with poor patient survival in nasopharyngeal carcinoma
Authors: Xu Yun , Guo Zhoubo , Peng Hewei , Guo Lanyan , Wang Ping 
Published: December 2021

AbstractMetastasis contributes to treatment failure in nasopharyngeal carcinoma (NPC) patients. Our study aimed at elucidating the role of insulin‐like growth factor 2 mRNA binding protein 3 (IGF2BP3) in NPC metastasis and the underlying mechanism involved. IGF2BP3 expression in NPC was determined by bioinformatics, quantitative polymerase chain reaction and immunohistochemistry analyses. The biological function of IGF2BP3 was investigated by using in vitro and in vivo studies. In this study, IGF2BP3 mRNA and protein levels were elevated in NPC tissues. In addition, IGF2BP3 exerted an oncogenic role by promoting epithelial‐mesenchymal transition (EMT), thereby inducing NPC cell migration and invasion. Further studies revealed that IGF2BP3 regulated the expression of key regulators of EMT by activating AKT/mTOR signalling, thus stimulating NPC cell migration and invasion. Remarkably, targeting IGF2BP3 delayed NPC metastasis through attenuating p‐AKT and vimentin expression and inducing E‐cadherin expression in vivo. Moreover, IGF2BP3 protein levels positively correlated with distant metastasis after initial treatment. Importantly, IGF2BP3 expression served as an independent prognostic factor in predicting the overall survival and distant metastasis‐free survival of NPC patients. This work identifies IGF2BP3 as a novel prognostic marker and a new target for NPC treatment.
Subcutaneous ureteral bypass device placement in 81 cats with benign ureteral obstruction (2013‐2018)
Authors: Wuillemin Florian , Vachon Catherine , Beauchamp Guy , Dunn Marilyn 
Published: December 2021

AbstractBackgroundBenign ureteral obstructions (BUOs) present a therapeutic challenge in cats.Hypothesis/ObjectivesThe purpose of this study was to determine the outcome and complications associated with placement of subcutaneous ureteral bypass (SUB) device in cats.AnimalsEighty‐one client‐owned cats (117 kidneys) with BUO treated by placement of a SUB.MethodsRetrospective study. Medical records of cats with BUO and treated by SUB device placement between 2013 and 2018 were reviewed. Outcome and complications were documented.ResultsHospital discharge rate was 94% (76/81). Serum creatinine on admission and at the time of discharge was 5.3 mg/dL (range, 1.2 to >15 mg/dL) and 2.1 mg/dL (range, 1.1‐12.5 mg/dL), respectively. Luminal obstructions were documented in 17% (18/109) of the SUB devices of 16 cats discharged from the hospital. Infection was documented in 26% (20/76) of discharged cats. Kink of the device was documented in 10% (12/117) of devices. Time to luminal obstruction and kink were 204 days (range, 21‐1678 days) and 58 days (range, 2‐601 days), respectively. Fourteen of 81 (17%) cats required a revision surgery in order to restore patency of the device. At the time of writing, 53% (43/81) of cats were alive, with a mean survival time of 821 days (range, 1‐2170 days) after surgery. Of those that died, 52% (20/38) died of urinary related causes.Conclusion and Clinical ImportanceThis study suggests that SUB device placement is associated with good outcomes and could be considered for the treatment of BUO in cats.
Determining influence, interaction and causality of contrast and sequence effects in objective structured clinical exams
Authors: Yeates Peter , Moult Alice , Cope Natalie , McCray Gareth , Fuller Richard , McKinley Robert 
Published: December 2021

AbstractIntroductionDifferential rater function over time (DRIFT) and contrast effects (examiners' scores biased away from the standard of preceding performances) both challenge the fairness of scoring in objective structured clinical exams (OSCEs). This is important as, under some circumstances, these effects could alter whether some candidates pass or fail assessments. Benefitting from experimental control, this study investigated the causality, operation and interaction of both effects simultaneously for the first time in an OSCE setting.MethodsWe used secondary analysis of data from an OSCE in which examiners scored embedded videos of student performances interspersed between live students. Embedded video position varied between examiners (early vs. late) whilst the standard of preceding performances naturally varied (previous high or low). We examined linear relationships suggestive of DRIFT and contrast effects in all within‐OSCE data before comparing the influence and interaction of ‘early’ versus ‘late’ and ‘previous high’ versus ‘previous low’ conditions on embedded video scores.ResultsLinear relationships data did not support the presence of DRIFT or contrast effects. Embedded videos were scored higher early (19.9 [19.4–20.5]) versus late (18.6 [18.1–19.1], p < 0.001), but scores did not differ between previous high and previous low conditions. The interaction term was non‐significant.ConclusionsIn this instance, the small DRIFT effect we observed on embedded videos can be causally attributed to examiner behaviour. Contrast effects appear less ubiquitous than some prior research suggests. Possible mediators of these finding include the following: OSCE context, detail of task specification, examiners' cognitive load and the distribution of learners' ability. As the operation of these effects appears to vary across contexts, further research is needed to determine the prevalence and mechanisms of contrast and DRIFT effects, so that assessments may be designed in ways that are likely to avoid their occurrence. Quality assurance should monitor for these contextually variable effects in order to ensure OSCE equivalence.
Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex
Authors: Stiens Jennifer , Arnvig Kristine B. , Kendall Sharon L. , Nobeli Irene 
Published: December 2021

AbstractA definitive transcriptome atlas for the non‐coding expressed elements of the members of the Mycobacterium tuberculosis complex (MTBC) does not exist. Incomplete lists of non‐coding transcripts can be obtained for some of the reference genomes (e.g., M. tuberculosis H37Rv) but to what extent these transcripts have homologues in closely related species or even strains is not clear. This has implications for the analysis of transcriptomic data; non‐coding parts of the transcriptome are often ignored in the absence of formal, reliable annotation. Here, we review the state of our knowledge of non‐coding RNAs in pathogenic mycobacteria, emphasizing the disparities in the information included in commonly used databases. We then proceed to review ways of combining computational solutions for predicting the non‐coding transcriptome with experiments that can help refine and confirm these predictions.
Contractility patterns and gastrointestinal movements monitored by a combined magnetic tracking and motility testing unit
Authors: Liao Donghua , Mark Esben Bolvig , Nedergaard Rasmus Bach , Wegeberg Anne‐Marie , Brock Christina , Krogh Klaus , Drewes Asbjørn Mohr 
Published: December 2021

AbstractBackgroundIngestible wireless capsules, including the 3D‐transit magnetic capsule and the wireless motility capsule (WMC), describe gastrointestinal (GI) motility from changes in position or pressure. This study aimed to combine information on contractile events in terms of position (assessed with the 3D‐transit) and change in pressure (assessed with the WMC) throughout the entire GI tract.MethodsThe 3D‐transit capsule and WMC were combined into a single‐wireless unit system. Three‐dimensional space‐time coordinates, pressure, and pH data from a pilot case were analyzed as the combined unit passed the GI tract. Two single and three continuous contraction patterns were defined according to pressure changes and quantified through the GI tract.Key resultsThe combined unit was well tolerated and provided information on contractions throughout the gut. Single contraction patterns with no significant progressive movement of the unit were most prevalent in the stomach and the rectosigmoid colon. During the continuous contraction patterns, the unit moved in an antegrade or retrograde direction. Longer distance and higher velocity were seen during antegrade than during retrograde movements. The motility indices (as measured with WMC) in combined ascending, transverse and descending colon showed a positive linear association (r = 0.7) to the capsule movements (as measured with 3D‐transit).Conclusions & inferencesThe combined system provides synchronous information about movements and gut contractions. These measurements can be used to extract more information from existing recordings and may enhance our understanding of GI motility in health and disease.