bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eddy-Mediated Hadley Cell Expansion due to Axisymmetric Angular Momentum Adjustment to Greenhouse Gas Forcings
Authors: Davis Nicholas A. , Birner Thomas 
Published: March 2021

Abstract
The poleward expansion of the Hadley cells is one of the most robust modeled responses to increasing greenhouse gas concentrations. There are many proposed mechanisms for expansion, and most are consistent with modeled changes in thermodynamics, dynamics, and clouds. The adjustment of the eddies and the mean flow to greenhouse gas forcings, and to one another, complicates any effort toward a deeper understanding. Here we modify the Gray Radiation and Moist Aquaplanet (GRANDMA) model to uncouple the eddy and mean flow responses to forcings. When eddy forcings are held constant, the purely axisymmetric response of the Hadley cell to a greenhouse gas–like forcing is an intensification and poleward tilting of the cell with height in response to an axisymmetric increase in angular momentum in the subtropics. The angular momentum increase drastically alters the circulation response compared to axisymmetric theories, which by nature neglect this adjustment. Model simulations and an eddy diffusivity framework demonstrate that the axisymmetric increase in subtropical angular momentum—the direct manifestation of the radiative–convective equilibrium temperature response—drives a poleward shift of the eddy stresses which leads to Hadley cell expansion. Prescribing the eddy response to the greenhouse gas–like forcing shows that eddies damp, rather than drive, changes in angular momentum, moist static energy transport, and momentum transport. Expansion is not driven by changes in baroclinic instability, as would otherwise be diagnosed from the fully coupled simulation. These modeling results caution any assessment of mechanisms for circulation change within the fully coupled wave–mean flow system.
Erasing the Vision Splendid? Unpacking the Formative Responses of the Federal Courts to the Fast Track Processing Regime and the ‘Limited Review’ of the Immigration Assessment Authority
Authors: Townsend Joel , Kerwin Hollie 
Published: March 2021

AbstractThe establishment of the Immigration Assessment Authority (‘IAA’) and the Fast Track Processing Regime for certain asylum seekers has posed new and important questions for Australian administrative law, especially in respect of the place, scope and effect of merits review. This article considers the early and formative jurisprudence of the federal courts in relation to ‘Fast Track decisions’ made by the IAA. It concludes that the Fast Track process represents a novel development in Australian public law: a partial review process which is not sufficient to correct the errors of the decision-maker at first instance but which appeared for a time capable of immunising elements of the decision from appeal or direct judicial review. It is, in its intention and current operation, more than a ‘targeted tinkering’ with the mechanics of merits review and of migration law in Australia. It deserves attention as it commences its journey through superior courts and as the regime settles into the Australian administrative law landscape.
Investigating the Impact of Cognitive Training for Individuals With Bothersome Tinnitus: A Randomized Controlled Trial
Authors: Xing Maggie , Kallogjeri Dorina , Piccirillo Jay F. 
Published: March 2021

ObjectiveTo evaluate the effectiveness of cognitive training in improving tinnitus bother and to identify predictors of patient response.Study DesignProspective open‐label randomized controlled trial.SettingOnline.MethodsParticipants were adults with subjective idiopathic nonpulsatile tinnitus causing significant tinnitus‐related distress. The intervention group trained by using auditory‐intensive exercises for 20 minutes per day, 5 days per week, for 8 weeks. The active control group trained on the same schedule with non–auditory intensive games. Surveys were completed at baseline, 8 weeks, and 12 weeks.ResultsA total of 64 participants completed the study. The median age was 63 years (range, 25‐69) in the intervention group and 61 years (34‐68) in the control group. Mixed model analysis revealed that within‐subject change in Tinnitus Functional Index in the intervention group was not different than the control group, with marginal mean differences (95% CI): 0.24 (–11.20 to 10.7) and 2.17 (–8.50 to 12.83) at 8 weeks and 2.33 (–8.6 to 13.3) and 3.36 (–7.91 to 14.6) at 12 weeks, respectively. When the 2 study groups were compared, the control group had higher Tinnitus Functional Index scores than the intervention group by 10.5 points at baseline (95% CI, –0.92 to 29.89), 8.1 at 8 weeks (95% CI, –3.27 to 19.42), and 9.4 at 12 weeks (95% CI, –2.45 to 21.34).ConclusionAuditory‐intensive cognitive training was not associated with changes in self‐reported tinnitus bother. Given the potential for neuroplasticity to affect tinnitus, we believe that future studies on cognitive training for tinnitus remain relevant.
Generic Clopidogrel: Has Substitution for Brand Name Plavix® Been Effective?
Authors: Westphal Erica S. , Aladeen Traci , Vanini Denis , Rainka Michelle , McCadden Kaitlin , Gengo Francis M. , Bates Vernice 
Published: March 2021

Background: Following the expiration of brand name exclusivity of Plavix® in 2012, generic clopidogrel bisulfate was approved. As a widely prescribed medication with significant inter-patient pharmacokinetic and pharmacodynamic variability, data regarding the impact of switching to generic clopidogrel bisulfate on patients is needed. Objective: The objective of this study was to determine whether generic clopidogrel bisulfate is as efficacious as Plavix® for the inhibition of platelet aggregation. Methods: Patients treated with Plavix® monotherapy (n = 254) or generic clopidogrel bisulfate monotherapy (n = 185) were included in this retrospective review. Confounding factors previously found to affect clopidogrel responsiveness (diabetes, female sex, and smoking) were assessed, as well as medications classified as substrates, inducers, and inhibitors of enzymes involved in clopidogrel metabolism. Whole blood impedance aggregometry was used to measure platelet aggregation in response to adenosine diphosphate. Patients were tested after ≥2 weeks of treatment and designated as non-responders if aggregation response exceeded sensitivity thresholds of 6 ohms of impedance. Results: The introduction of generic clopidogrel bisulfate was associated with a decrease in antiplatelet resistance (44% to 31%, p < 0.01) and decreased mean ohms of resistance (5.06 ± 4.55 to 3.32 ± 4.03, p < 0.01). Prior to analysis of secondary outcomes, 217 patients were eliminated due to antiplatelet usage for longer than 3 years (n = 123 for Plavix® and n = 118 for clopidogrel). There was no statistically significant finding in prevalence of secondary events. Conclusion: Resistance rates to the antiplatelet, clopidogrel are significantly lower since the switch to generic formulations. Further investigation into the impact of variability between clopidogrel bisulfate formulations is needed.
Interdisciplinary Considerations for Nasolabial Repair During a Global Pandemic
Authors: Santos Pauline Joy F. , Arowojolu Omotayo A. , Vyas Raj M. 
Published: March 2021

Background: At the declaration of the global pandemic on March 11, 2020, many hospitals and institutions developed a tiered framework for the stratification and prioritization of elective surgery. Cleft lip and palate repair was classified as low acuity, and nasoalveolar molding (NAM) clinics were closed. Anticipating the consequences of delayed cleft care and the additional burden this would cause families, we reassessed our risk-stratification and perioperative algorithms. We hypothesized we could safely optimize nasolabial repair without burdening our care systems and without increasing COVID-19–related morbidity/mortality. Methods: Our multidisciplinary cleft team reevaluated patient selection to maximize surgical impact. Perioperative protocols were adjusted, and COVID-19 preoperative testing was utilized before nasolabial repair and prior to suture removal under anesthesia. Results: Early in the pandemic, unilateral cleft repair was prioritized and successfully completed on 9 patients. There were no complications related to COVID-19. Nasoalveolar molding clinic was reopened after total patient volume was significantly decreased. Conclusions: We offer an approach for surgical management of nasolabial clefts during a global pandemic. Although guidelines have suggested postponing all cleft care, we found that at our dedicated pediatric hospital with low burden of COVID-19 and adequate resources, we could follow a strategy to safely resume cleft care while decreasing burden on our patients’ families and care delivery systems.
A Comprehensive Analysis of the Behavior of Pelvic Incidence After Different Posterior Spinal Procedures in Elderly Patients With Spinal Deformity
Authors: Zhu Weiguo , Wang Yu , Kong Chao , Sun Xiangyao , Pan Fumin , Wang Wei , Lu Shibao 
Published: March 2021

Study Design: A retrospective case-control study. Objective: To evaluate the behavior of pelvic incidence (PI) after different posterior spinal procedures in elderly patients with adult spinal deformity (ASD), to determine the potential associated factors with the variability in PI after spinal surgery and to comprehensively analyze its mechanisms. Methods: Elderly patients underwent long fusion to sacrum with and without pelvic fixation were assigned to Group L+P and Group L-P, respectively. In Group L-P, those with severe sagittal deformity were selected as Group A. 20 elderly patients with severe sagittal deformity underwent short lumbar fusion were included as Group B. The following radiographic parameters were evaluated: thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), lumbar lordosis (LL), PI-LL, sagittal vertical axis (SVA), T1 pelvic angle (TPA), and pelvic parameters. PI changing more than 5° (△PI > 5°) was considered as substantially changed. Results: For the whole cohort and in Group L+P, PI were not substantially changed (△PI ≤ 5°) after surgery. Besides the severer sagittal malalignment in patients with △PI > 5° in Group L-P, relatively larger mean age, greater proportion of female and lower preoperative PI were found than those in patients with △PI ≤ 5°. 70.8% of patients had substantial increase of PI in Group A, while only 10% of patients had in Group B ( P < 0.001). Conclusion: PI behaves differently under different conditions in elderly ASD patients. Besides severe sagittal deformity, aging, female and low preoperative PI are also the potential risk factors of PI increasing after long fusion to sacrum.
Usefulness and limitation of indocyanine green fluorescence for detection of peritoneal recurrence after hepatectomy for hepatocellular carcinoma: a case report
Authors: Hayashi Hikaru , Shimizu Akira , Motoyama Hiroaki , Kubota Koji , Notake Tsuyoshi , Sugenoya Shinsuke , Hosoda Kiyotaka , Yasukawa Koya , Kobayashi Ryoichiro , Soejima Yuji 
Published: March 2021

Abstract
Background
Peritoneal recurrence of hepatocellular carcinoma (HCC) after hepatectomy occurs rarely, accounting for less than 1% of all recurrences. Reported causes of such dissemination include a history of rupture of the original HCC, needle biopsy or puncture treatment, and surgical procedures. There is no consensus on the optimal treatment strategy for peritoneal dissemination. There have been few reports on assisting resection of peritoneal dissemination by using indocyanine green (ICG) fluorescence.

Case presentation
A 57-year-old man underwent posterior sectionectomy for HCC. Six months later, computed tomography revealed multiple nodules suspected of indicating peritoneal dissemination. Various preoperative imaging studies demonstrated only four nodules, the doubling time of the tumors being rapid at 22 days. The nodules were therefore resected. ICG (0.5 mg/kg) was injected intravenously 2 days before the procedure, enabling identification of the nodules by their brightness in the operative field under near-infrared lighting. A total of eight lesions were detected during the procedure and resected, some of which had not been identified by preoperative imaging studies. We diagnosed peritoneal dissemination of HCC based on the pathological findings and their similarity to those of the original HCC. We concluded that the recurrences were likely attributable to exposure of the tumor to the serosa at the time of the original operation.

Conclusions
Although ICG fluorescence is useful for identifying peritoneal dissemination of HCC, attention should be paid to the difficulty in detecting deep lesions and occurrence of false positives.
Comprehensive analysis of the transcriptome‐wide m6A methylome in invasive malignant pleomorphic adenoma
Authors: Han Zhenyuan , Yang Biao , Wang Qin , Hu Yuhua , Wu Yuqiong , Tian Zhen 
Published: March 2021

Abstract
Background
Invasive malignant pleomorphic adenoma (IMPA) is a highly invasive parotid gland tumor and lacks effective therapy. N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of mRNAs in eukaryotes and plays an important role in the pathogenesis of multiple tumors. However, the significance of m6A-modified mRNAs in IMPA has not been elucidated to date. Hence, in this study, we attempted to profile the effect of IMPA in terms of m6A methylation in mRNA.

Methods
Methylated RNA immunoprecipitation with next-generation sequencing (MeRIP-seq) and RNA sequencing (RNA-seq) were utilized to acquire the first transcriptome-wide profiling of the m6A methylome map in IMPA followed by bioinformatics analysis.

Results
In this study, we obtained m6A methylation maps of IMPA samples and normal adjacent tissues through MeRIP-seq. In total, 25,490 m6A peaks associated with 13,735 genes were detected in the IMPA group, whereas 33,930 m6A peaks associated with 18,063 genes were detected in the control group. Peaks were primarily enriched within coding regions and near stop codons with AAACC and GGAC motifs. Moreover, functional enrichment analysis demonstrated that m6A-containing genes were significantly enriched in cancer and metabolism relevant pathways. Furthermore, we identified a relationship between the m6A methylome and the RNA transcriptome, indicating a mechanism by which m6A modulates gene expression.

Conclusions
Our study is the first to provide comprehensive and transcriptome-wide profiles to determine the potential roles played by m6A methylation in IMPA. These results may open new avenues for in-depth research elucidating the m6A topology of IMPA and the molecular mechanisms governing the formation and progression of IMPA.
RETRACTED ARTICLE: LINC01089 functions as a ceRNA for miR-152-3p to inhibit non‐small lung cancer progression through regulating PTEN
Authors: Zhang Huixian , Zhang Hao , Li Xingya , Huang Siyuan , Guo Qianqian , Geng Di 
Published: March 2021

Abstract
Background
Long non-coding RNAs (lncRNAs) have been reported to exert crucial functions in regulating the progression of human cancers. However, the function and mechanism of long intergenic non-protein coding RNA 01089 (LINC01089) in non-small cell lung cancer (NSCLC) have not been revealed.

Methods
The expression level of LINC01089, microRNA (miRNA, miR)-152-3p and phosphatase and tensin homolog deleted onc hromosome ten (PTEN) mRNA was detected by quantitative real-time PCR (qRT-PCR). After gain-of-function and loss-of-function models were established with NSCLC cell lines, the proliferation, migration and invasion of NSCLC cells were detected by cell counting kit-8 (CCK-8) assay, scratch healing assay, Transwell assay, respectively. Dual luciferase reporter assay was employed to validate the binding relationship between miR-152-3p and LINC01089 or the 3’UTR of PTEN. Western blot was used to detect PTEN expression in NSCLC cells after LINC01089 and miR-152-3p were selectively modulated.

Results
LINC01089 was down-regulated in NSCLC tissues and cells. Functional experiments showed that knockdown of LINC01089 could promote the proliferation, migration and invasion of NSCLC cells, while over-expression of LINC01089 had the opposite effects. miR-152-3p was identified as a functional target for LIN01089, and miR-152-3p could reverse the function of LINC01089. Additionally, LINC01089 could up-regulate the expression level of PTEN via repressing miR-152-3p.

Conclusions
Down-regulation of LINC01089 promoted the progression of NSCLC through regulating miR-152-3p/PTEN axis.
RETRACTED ARTICLE: Improving the measurement of alexithymia in autistic adults: a psychometric investigation and refinement of the twenty-item Toronto Alexithymia Scale
Authors: Williams Zachary J. , Gotham Katherine O. 
Published: March 2021

AbstractBackgroundAlexithymia, a personality trait characterized by difficulties interpreting one’s own emotional states, is commonly elevated in autistic adults, and a growing body of literature suggests that this trait underlies a number of cognitive and emotional differences previously attributed to autism, such as difficulties in facial emotion recognition and reduced empathy. Although questionnaires such as the twenty-item Toronto Alexithymia Scale (TAS-20) are frequently used to measure alexithymia in the autistic population, few studies have attempted to determine the psychometric properties of these questionnaires in autistic adults, including whether differential item functioning (I-DIF) exists between autistic and general population adults.MethodsWe conducted an in-depth psychometric analysis of the TAS-20 in a large sample of 743 verbal autistic adults recruited from the Simons Foundation SPARK participant pool and 721 general population controls enrolled in a large international psychological study (the Human Penguin Project). The factor structure of the TAS-20 was examined using confirmatory factor analysis, and item response theory was used to further refine the scale based on local model misfit and I-DIF between the groups. Correlations between alexithymia and other clinical outcomes such as autistic traits, anxiety, and quality-of-life were used to assess the nomological validity of the revised alexithymia scale in the SPARK sample.ResultsThe TAS-20 did not exhibit adequate global model fit in either the autistic or general population samples. Empirically driven item reduction was undertaken, resulting in an eight-item unidimensional scale (TAS-8) with sound psychometric properties and practically ignorable I-DIF between diagnostic groups. Correlational analyses indicated that TAS-8 scores meaningfully predict autistic trait levels, anxiety and depression symptoms, and quality of life, even after controlling for trait neuroticism.LimitationsLimitations of the current study include a sample of autistic adults that was overwhelmingly female, later-diagnosed, and well-educated; clinical and control groups drawn from different studies with variable measures; and an inability to test several other important psychometric characteristics of the TAS-8, including sensitivity to change and I-DIF across multiple administrations.ConclusionsThese results indicate the potential of the TAS-8 as a psychometrically robust tool to measure alexithymia in both autistic and non-autistic adults. A free online score calculator has been created to facilitate the use of norm-referenced TAS-8 latent trait scores in research applications (available athttp://asdmeasures.shinyapps.io/TAS8_Score).
Development of a regional voice dataset and speaker classification based on machine learning
Authors: Ismail Muhammad , Memon Shahzad , Dhomeja Lachhman Das , Shah Shahid Munir , Hussain Dostdar , Rahim Sabit , Ali Imran 
Published: March 2021

AbstractAt present, voice biometrics are commonly used for identification and authentication of users through their voice. Voice based services such as mobile banking, access to personal devices, and logging into social networks are the common examples of authenticating users through voice biometrics. In Pakistan, voice-based services are very common in banking and mobile/cellular sector, however, these services do not use voice features to recognize customers. Therefore, the chance to use these services with false identity is always high. It is essential to design a voice-based recognition system to minimize the risk of false identity. In this paper, we developed regional voice datasets for voice biometrics, by collecting voice data in different local accents of Pakistan. Although, there is a global need for voice biometrics especially when voice-based services are common, however, this paper uses Pakistan as a use case to show how to build regional voice dataset for voice biometrics. To build voice dataset, voice samples were recorded from 180 male and female speakers with two languages English and Urdu in form of five regional accents. Mel Frequency Cepstral Coefficient (MFCC) features were extracted from the collected voice samples to train Support Vector Machine (SVM), Artificial Neural Network (ANN), Random Forest (RF) and K-nearest neighbor (KNN) classifiers. The results indicate that ANN outperformed SVM, RF and KNN by achieving 88.53% and 86.58% recognition accuracy on both datasets respectively.
Sustainable hydrogen production from water using tandem dye-sensitized photoelectrochemical cells
Authors: Sherman Benjamin D. , McMillan Nelli Klinova , Willinger Debora , Leem Gyu 
Published: March 2021

AbstractIf generated from water using renewable energy, hydrogen could serve as a carbon-zero, environmentally benign fuel to meet the needs of modern society. Photoelectrochemical cells integrate the absorption and conversion of solar energy and chemical catalysis for the generation of high value products. Tandem photoelectrochemical devices have demonstrated impressive solar-to-hydrogen conversion efficiencies but have not become economically relevant due to high production cost. Dye-sensitized solar cells, those based on a monolayer of molecular dye adsorbed to a high surface area, optically transparent semiconductor electrode, offer a possible route to realizing tandem photochemical systems for H2 production by water photolysis with lower overall material and processing costs. This review addresses the design and materials important to the development of tandem dye-sensitized photoelectrochemical cells for solar H2 production and highlights current published reports detailing systems capable of spontaneous H2 formation from water using only dye-sensitized interfaces for light capture.