bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of paracetamol in sows around farrowing: effect on health and condition of the sow, piglet mortality, piglet weight and piglet weight gain
Authors: Kuller Wikke , Sietsma Steven , Hendriksen Susan , Sperling Daniel 
Published: August 2021

AbstractBackgroundPain and fever in the periparturient period can lead to prolonged farrowing and can slow down the recovery of the sow, which will have an effect on the vitality and survival of the piglets. This study investigated the use of orally administered Paracetamol (Pracetam- CEVA) in sows in the periparturient period.ResultsMortality did not differ in piglets during the first week, or during total lactation (P > 0.10). No difference was found in weight or weight gain of the piglets during lactation. The coefficient of variation of piglet weight was smaller in the Paracetamol (Pm) group at day 7, day 14 and at weaning, but not at birth. So, the variation within litters was smaller in the Pm- treated sows, in comparison with the Control (C) litters. No difference in mean IgG concentration was found between treatments, but the coefficient of variation was too high (> 40) in 50% of the C litters and not in Pm litters. The Pm- treated sows lost less backfat than the C- sows. No effect was found on the body temperature of the sows, but fever was rare in both groups.ConclusionParacetamol results in less variation of body weight of piglets during lactation, seems to have a potential effect on the distribution of IgG within litters and has a positive effect on backfat loss. The effects of Paracetamol might be even more pronounced in farms with high piglet mortality (this farm only 8%) or with a high incidence of agalactia, fever after farrowing or piglet diarrhoea, which was not the case in this farm. Paracetamol is a promising product for increasing the welfare in lactating sows and optimising production in the farrowing stable.
Feasibility study of a digitalized nurse practitioner-led intervention to improve medication adherence in type 2 diabetes patients in Dutch primary care
Authors: Hogervorst Stijn , Adriaanse Marcel , Brandt Hella , Vervloet Marcia , van Dijk Liset , Hugtenburg Jacqueline 
Published: August 2021

Abstract
Purpose
The purpose of this feasibility study was to improve and implement an intervention aimed at enhancing medication adherence in sub-optimally controlled and non-adherent type 2 diabetes (T2DM) patients in primary care.

Methods
Four phases were completed: (1) context analysis, (2) collaboration protocol development, (3) digitalization, and (4) process evaluation. Two community pharmacies and seven general practices participated. In phase 1, two focus groups were conducted, of which one with healthcare providers (HCP, N = 5) and one with patients (N = 11). In phase 4, four semi-structured interviews and one focus group (N = 6) were conducted with healthcare providers. The goal of these focus groups and interviews was to obtain insights into current care to support medication adherence (phase 1), opportunities for collaboration (phase 2) and process evaluation (phase 4). Data were analyzed in Atlas.ti using thematic analyses.

Results
Both T2DM patients and HCPs considered medication adherence vital. Suboptimal collaboration between HCPs and unreliable ways to monitor medication non-adherence appeared important barriers for adequate care to support medication adherence (phase 1). The nurse practitioner (NP) was chosen as the interventionist with supportive roles for other HCPs (phase 2). All components of the intervention were digitalized (phase 3). The implementation of the digitalized intervention was reported to be suboptimal (phase 4). Main reasons were that pharmacy refill data were unreliable, NPs experienced difficulties addressing medication non-adherence adequately and collaboration between HCPs was suboptimal.

Conclusions
The medication adherence enhancing intervention was successfully digitalized, but implementation of the digitalized intervention appeared not feasible as of yet.
Low Levels of Serum Sclerostin in Adult Patients With Tumor-Induced Osteomalacia Compared With X-linked Hypophosphatemia
Authors: Ni Xiaolin , Zhang Qi , Li Xiang , Pang Qianqian , Gong Yiyi , Wang Ou , Li Mei , Xing Xiaoping , Jiang Yan , Xia Weibo 
Published: August 2021

Abstract

Context
Sclerostin inhibits Wnt-β-catenin signaling, regulating bone formation. Circulating sclerostin was reported to be elevated in X-linked hypophosphatemia (XLH) patients, and sclerostin antibody (Scl-Ab) increased bone mass and normalized circulating phosphate in Hyp mice. However, circulating sclerostin levels in patients with acquired hypophosphatemia due to tumor-induced osteomalacia (TIO) are rarely reported.

Objective
This study was designed to evaluate serum sclerostin levels in TIO patients compared with age- and sex-matched healthy controls and XLH patients to analyze correlations with bone mineral density (BMD) and laboratory parameters.

Methods
This cross-sectional study determined serum sclerostin levels in 190 individuals, comprising 83 adult TIO patients, 83 adult healthy controls and 24 adult XLH patients.

Results
TIO patients (43 male, 40 female) aged 44.3 ± 8.7 (mean ± SD) years had lower levels of circulating sclerostin than controls (94.2 ± 45.8 vs 108.4 ± 42.3 pg/mL, P = 0.01), adjusted for age, gender, BMI, and diabetes rate. Sclerostin levels were positively associated with age (r = 0.238, P = 0.030). Male patients had higher sclerostin than female patients (104.7 ± 47.3 vs 83.0 ± 41.8 pg/mL, P = 0.014). Sclerostin levels were positively associated with L1-4 BMD (r = 0.255, P = 0.028), femoral neck BMD (r = 0.242, P = 0.039), and serum calcium (r = 0.231, P = 0.043). Comparison of sclerostin levels in TIO patients (n = 24, age 35.9 ± 7.3 years) vs XLH patients vs healthy controls revealed significant differences (respectively, 68.4 ± 31.3, 132.0 ± 68.8, and 98.6 ± 41.1 pg/mL, P &lt; 0.001).

Conclusion
Circulating sclerostin was decreased in TIO patients but increased in XLH patients, possibly due to histological abnormality and bone mass.
Efficiency changes in orthopaedic trauma surgery and implications for resource allocation
Authors: Virani Siddharth , Faria Giles , Housden Philip 
Published: August 2021

Background/Aims The trauma and orthopaedic surgery department needed to modify practices as a result of the COVID-19 pandemic. This study quantitatively assessed the effects of changes in resource allocation on the efficiency of trauma, specifically the number of operations performed per defined trauma session. Methods Trauma lists were reviewed pre-COVID, at the peak and at the tail of the first wave of COVID-19 infections at a hospital in the UK. Efficiency was calculated before and after the reallocation of resources and this was defined as the number of cases per trauma session as well as turnaround times for each part of the surgical patient journey. Results The mean trauma list efficiency was 1.73 cases per session in February 2020 compared to 1.89 in February 2019. It reduced to 1.21 during the COVID peak in April 2020 compared to 1.90 in April 2019 and improved to 1.48 per session in June 2020 vs 1.82 in June 2019. Conclusions Measures introduced at the start of the pandemic are likely to continue for the foreseeable future. Increased allocation of resources would be needed to allow urgent trauma surgery to provide a timely and efficient service.
Stationary sets of the mean curvature flow with a forcing term
Authors: Julin Vesa , Niinikoski Joonas 
Published: August 2021

Abstract
We consider the flat flow solution to the mean curvature equation with forcing in

ℝ
n

{\mathbb{R}^{n}}

.
Our main result states that tangential balls in

ℝ
n

{\mathbb{R}^{n}}

under a flat flow with a bounded forcing term will
experience fattening, which generalizes the result in
[N. Fusco, V. Julin and M. Morini,
Stationary sets and asymptotic behavior of the mean curvature flow with forcing in the plane,
preprint 2020, https://arxiv.org/abs/2004.07734]
from the planar case to higher dimensions. Then, as in the planar case, we characterize stationary sets in

ℝ
n

{\mathbb{R}^{n}}

for a constant forcing term as finite unions of equisize balls with mutually positive distance.
Convergence Theory for IETI-DP Solvers for Discontinuous Galerkin Isogeometric Analysis that is Explicit in ℎ and 𝑝
Authors: Schneckenleitner Rainer , Takacs Stefan 
Published: August 2021

AbstractIn this paper, we develop a convergence theory for Dual-Primal Isogeometric Tearing and Interconnecting (IETI-DP) solvers for isogeometric multi-patch discretizations of the Poisson problem, where the patches are coupled using discontinuous Galerkin. The presented theory provides condition number bounds that are explicit in the grid sizes ℎ and in the spline degrees 𝑝. We give an analysis that holds for various choices for the primal degrees of freedom: vertex values, edge averages, and a combination of both. If only the vertex values or both vertex values and edge averages are taken as primal degrees of freedom, the condition number bound is the same as for the conforming case. If only the edge averages are taken, both the convergence theory and the experiments show that the condition number of the preconditioned system grows with the ratio of the grid sizes on neighboring patches.
Pedagogy, Didactics, or Subject Matter? Exploring Pre-service Teachers’ Interest Profiles
Authors: Pozas Marcela , Letzel Verena 
Published: August 2021

Abstract
Interest has been considered an important determinant of teacher quality. However, research into teacher interest, and more specifically, pre-service teachers’ interest is limited. Hence, the current study tackled the current gaps in pre-service teachers’ interest and aimed to explore pre-service teachers’ interest profiles based on the multidimensional framework of teacher interest. A total of 225 pre-service teachers, enrolled in various initial teacher education programs of two universities in Germany, participated voluntarily in the study. The results revealed two distinct pre-service teachers’ profiles based on the three teacher interest factors. Interestingly, the two profiles did not significantly differ in their subject interest levels, but did vary in their didactic and educational interest. In addition, the findings also revealed gender and school track differences in pre-service teachers’ interests and profiles. Consequences for future research and teacher education are discussed in detail.
Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
Authors: Suksaeree Jirapornchai , Chaichawawut Benjarut , Srichan Muntira , Tanaboonsuthi Noppamon , Monton Chaowalit , Maneewattanapinyo Pattwat , Pichayakorn Wiwat 
Published: August 2021

Abstract
Design of experiments is used to optimize ratios between deproteinized natural rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent variables as moisture content, moisture uptake, and swelling index in simulated saliva 3 and 5 h. Mathematical models were linear for moisture content and moisture uptake, while swelling index in simulated saliva 3 and 5 h was a quadratic model. Optimized polymer ratio was 0.319:0.362:0.319, respectively. Experimental values were 13.17 ± 0.92%, 3.96 ± 0.84%, 112.58 ± 22.63%, and 124.69 ± 8.01% for dependent variables, respectively. The buccal film showed high swelling at pH 7 and swelling–deswelling behaviors in a water/ethanol environment. The surface pH, weight, and thickness were 8.11, 63.28 ± 6.18 mg, and 219.87 ± 44.28 µm, respectively. Nicotine content was found as 10.22 ± 0.46 mg/4 cm2. Maximum cumulative nicotine release was 9.82 ± 0.94 mg/4 cm2. Kinetic model fitted to the Korsmeyer-Peppas model and release exponent was 0.36, representing that release mechanism was controlled by Fickian diffusion release.
Entrepreneurial Team Conflict and Cohesion: Meta-structural Equation Modeling
Authors: Yoo Sangok , Lee Jin , Lee Yunsoo 
Published: August 2021

Abstract
We explore the mediating effects that entrepreneurial team conflict and cohesion have on the relationship between team diversity and performance based on an inputs-mediators-outcomes framework. Using 56 samples from 54 empirical studies, we conducted a meta-analysis of the hypothesized relationships and used meta-analytic structural equation modeling (MASEM) to test the mediating models. Our findings reveal that team diversity was related to cognitive and affective conflict, and only affective conflict was associated with objective and subjective venture performance. Furthermore, entrepreneurial team cohesion had positive effects on venture performance. Our unique contributions to the entrepreneurial team literature and future research suggestions are also discussed.
Gross–Prasad periods for reducible representations
Authors: Loeffler David 
Published: August 2021

Abstract
We study

GL
2

⁡

(
F
)

{\operatorname{GL}_{2}(F)}

-invariant periods on representations of

GL
2

⁡

(
A
)

{\operatorname{GL}_{2}(A)}

, where F is a non-archimedean local field and

A
/
F

{A/F}

a product of field extensions of total degree 3. For irreducible representations, a theorem of Prasad shows that the space of such periods has dimension

⩽
1

{\leqslant 1}

, and is non-zero when a certain ε-factor condition holds. We give an extension of this result to a certain class of reducible representations (of Whittaker type), extending results of Harris–Scholl when A is the split algebra

F
×
F
×
F

{F\times F\times F}

.
Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
Authors: Ashraf Naheed , Sumrra Sajjad H. , Assiri Mohammed A. , Usman Muhammad , Hussain Riaz , Aziz Farooq , Hussain Ajaz , Ghaffari Muhammad Abuzar , Qaisar Muhammad Naeem , Imran Muhammad , Irfan Ahmad 
Published: August 2021

Abstract
Herein, we report a simple and ecofriendly synthesis of ZnO nanoparticles (ZnO NPs) employing Digera muricata along with bioassay studies of synthesized NPs. The ZnO NPs obtained were indicated by a colour change from yellow to almost faint yellow giving whitish tinge and supported by the appearance of UV-Vis band at 373 nm and were characterized by using Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray (EDX), and scanning electron microscopy (SEM). The FT-IR spectrum confirmed the presence of biomolecules fabricated on ZnO NPs as indicated by the absorption bands at 1,378 for C–O  cm−1, and ZnO NPs were also evident from the absorption bands at 440 and 670 cm−1, the former being the result of symmetric vibration of hexagonal ZnO and the latter belonged to a very weak vibration of ZnO. Its surface morphology was confirmed by SEM, and the zinc and oxygen bonds were confirmed by EDX analysis giving sharp signals for Zn and oxygen with At% of 17.58 and 30.49, respectively. The antimicrobial activity of ZnO nanoparticles was determined by the agar well diffusion method against pathogenic bacterial and fungal strains using imipenem and miconazole as standards. The results reflected that ZnO NPs enhanced the activity of plant extracts against all employed algal (E. coli, S. faecalis, P. aeruginosa, K. pneumonia, S. aureus, and B. subtilis) and fungal (T. mentogrophytes, E. floccosum, A. niger, M. canis, and F. culmorum) strains. The antibacterial and antifungal activities of extracts were enhanced by the formation of ZnO NPs. The results indicated that Digera muricata extract contains effective reducing agents for green synthesis of Digera muricata fabricated ZnO NPs, which are more potent antimicrobial than the plant extract and showed almost similar inhibition against lipoxygenase, i.e., the IC50 value of 83.82 ± 1.15, comparable to the standard.
Near-infrared spectroscopy and hyperspectral imaging can aid in the prediction and mapping of polyploid acacia hybrid wood properties in tree improvement programs
Authors: Viet Dang Duc , Ma Te , Inagaki Tetsuya , Kim Nguyen Tu , Tsuchikawa Satoru 
Published: August 2021

Abstract

Acacia, including Acacia hybrids, are some of the most important species grown as part of the Vietnamese wood industry. Rapid methods to identify the variations in the wood properties of Acacia hybrids however, are a currently lacking and creating limits for their breeding programs. In this study, nine Acacia hybrid clones, including those that were diploid, triploid, and tetraploid were evaluated using near-infrared spectroscopy (NIR) and hyperspectral imaging (HSI). The standard normal variate (SNV) and second derivative (SP2D) were applied to compare the performances of NIR and HSI using partial least square regression. The HSI images were acquired at wavelengths from 1033 to 2230 nm and the SNV and SP2D described the variations in the wood properties. The NIR predicted the wood physical properties better than HSI, while they provided similar predictions for the mechanical properties. The mapping results showed low densities around the pith area and high densities near the bark. They also revealed that the air-dry moisture content changed at different positions within a disk and was dependent on its position within the tree. Overall, NIR and HSI were found to be potential wood property prediction tools, suitable for use in tree improvement programs.
PTEN protein expression has role in predicting disease-free-interval in endometrioid endometrial carcinoma
Authors: Shafiee Mohamad Nasir , Lim Wei Keith , Poh Shwen Shi Cheryl , Mohamed Yasin Ira Adila , Azemi Aina Fatini , Zakaria Muhammad Luqman , Hannaan Abdul Hafizz Abdul Muzhill , Mustangin Muaatamarulain , Chandralega Kampan Nirmala , Abd Aziz Nor Haslinda , Md Zain Reena Rahayu 
Published: August 2021

Abstract

Objectives
To determine the significance of tumour PTEN protein expression in endometrioid endometrial carcinoma (EEC) and it is correlation with tumour characteristics.

Methods
A total of 30 eligible archived paraffin-embedded tissue blocks from 61 EEC cases (January 2015–December 2017) were retrieved from the Histopathology Laboratory in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) following institutional ethic approval. For PTEN protein detection, immunohistochemistry (IHC) staining was performed and the data was correlated with clinicopathologic parameters.

Results
Fourteen samples (46.7%) showed positive PTEN protein expression, while 16 (53.3%) were negative. The mean age was 62.00 ± 9.51 years old, while the mean Body Mass Index (BMI) was 27.28 ± 7.16 kg/m2. There was no significant difference between age (p=0.27, 95% CI: −10.98 to 3.21) and BMI (p=0.67, 95% CI: −4.30 to 6.58) with PTEN protein expression. There were significant correlation between PTEN protein expression with myometrial invasion (p=0.010), but not with lymphovascular space invasion (p=0.743), grade (p=0.532), stage (p=0.733) and CA-125 level (p=0.47). The higher stage correlates with the presence of LVSI (p=0.002). PTEN positive associated with longer disease-free-interval (p=0.025), but not improving the overall survival (p=0.38)

Conclusions
Positive PTEN protein expression correlates with less myometrial invasion.
Lefty A is involved in sunitinib resistance of renal cell carcinoma cells via regulation of IL-8
Authors: Cui Ning , Han Qiang , Cao Qizhen , Wang Kejun , Zhou Xujia , Hou Pingzhi , Liu Chao , Chen Lungang , Xu Lin 
Published: August 2021

Abstract
Renal cell carcinoma (RCC) is the third most frequent malignancy within urological oncology. Sunitinib has been used as the standard of treatment for first-line RCC therapy. Understanding mechanisms of sunitinib resistance in RCC cell is important for clinical therapy and drug development. We established sunitinib resistant RCC cells by treating cells with increasing concentrations of sunitinib and named resistant cells as RCC/SR. Lefty A, an important embryonic morphogen, was increased in RCC/SR cells. Targeted inhibition of Lefty via its siRNAs restored the sensitivity of renal resistant cells to sunitinib treatment. It was due to that si-Lefty can decrease the expression of interleukin-8 (IL-8) in RCC/SR cells. Knockdown of IL-8 abolished Lefty-regulated sunitinib sensitivity of RCC cells. Mechanistically, Lefty can regulate IL-8 transcription via activation of p65, one major transcription factor of IL-8. Collectively, our present revealed that Lefty A can regulate sunitinib sensitivity of RCC cells of via NF-κB/IL-8 signals. It indicated that targeted inhibition of Lefty might be a potent approach to overcome sunitinib resistance of RCC.
The variable of gender and its interplay with mother tongue in the humor and laughter of bilingual couples
Authors: Ang-Tschachtli Silja 
Published: August 2021

Abstract
The variables of gender and mother tongue are usually considered independently in humor research. This article aims to explore the role of gender and its interplay with mother tongue in the production, reception, and assessment of humor among 10 bilingual, bicultural couples. It investigates whether the gender patterns commonly observed are also evident in these couples’ conversations, namely that women laugh more than men (Mehu, Marc & Robin I. M. Dunbar. 2008. Naturalistic observations of smiling and laughter in human group interactions. Behaviour 145(12). 1747–1780.), that women laugh more about men than the reverse (Jefferson, Gail. 2004. A note on laughter in ‘male-female’ interaction. Discourse Studies 6. 117–133. DOI:10.1177/1461445604039445.), and that men produce more humorous utterances than women do (Ross, Elaina M. & Jeffrey A. Hall. 2020. The traditional sexual script and humour in courtship. Humor: International Journal of Humor Research 33(2). 197–218. DOI:10.1515/humor-2019-0017.). On average, the female bilinguals produced 29.6% more laughter pulses and laughed 7.4% more frequently, and their laughter episodes were consistently longer than their partners’. However, the participants’ mother tongue was found to have a stronger influence on their production and reception of laughables than their gender, and the native speakers produced more successful laughables, despite their partners’ high level of L2 proficiency. Interestingly, the couples’ self-assessments often did not match their actual laughing behavior and appeared to be clearly gendered; no couple considered the female partner to be funnier, and several men even questioned their partner’s sense of humor, while male humor was often praised.
Degradation of pharmaceutical antibiotic (ciprofloxacin) by photocatalysis process using sol-gel based titanium dioxide nanoparticles
Authors: Parmar Nitesh , Srivastava Jitendra Kumar 
Published: August 2021

Abstract
This study is an attempt to the removal of Ciprofloxacin (CIP) antibiotic from simulated wastewater using a photocatalytic process. The photocatalytic process was carried out in a photocatalytic reactor in the presence of TiO2 nanoparticles. TiO2 nanoparticles were successfully prepared in a laboratory scale using sol-gel method with titanium-isopropoxide (TTIP) as titanium precursor. Prepared material was found very effective to the removal of CIP antibiotic. The maximum removal efficiency of 87.95% of ciprofloxacin from aqueous solution was achieved at the pH 5, catalyst doze of 40 mg L−1 with initial concentration of ciprofloxacin 5 mg L−1, and the reaction time of 100 min additionally; material characterization of TiO2 was presented in detail in terms of XRD, SEM, UV, and FTIR. It has been found that at the optimum condition the total operating cost indicated for the removal of ciprofloxacin from aqueous solution is 786.56 (INR/kg of CIP removal). This technique demonstrated that photocatalytic reaction in presence of TiO2 nanoparticles is well applicable to treat pharmaceutical wastewater.