bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protective effects of Ramelteon against 6‐OHDA‐induced cellular senescence in human SH‐SY5Y neuronal cells
Authors: Liu Dan , Gu Xinyi , Han Fang , Cai Ming , Liu Weijie , Han Li , Ma Qiang 
Published: July 2021

AbstractBackground and purposeParkinson's disease (PD) is a severe neurodegenerative disease with high morbidity in the elderly population. 6‐OHDA‐induced cell senescence is reported to be involved in the pathogenesis of PD. Ramelteon is an oral hypnotic agent that specifically targets the receptors of the suprachiasmatic nucleus in the human hypothalamus. Here, an investigation is made to see whether Ramelteon possesses a beneficial effect against 6‐OHDA‐induced cellular senescence in human SH‐SY5Y neuronal cells.MethodsThe release of LDH was detected to assess cytotoxicity and flow cytometry was conducted to evaluate the cell cycle. The telomerase activity and the SA‐β‐Gal assay were performed to determine the state of cell senescence. Oxidative stress was evaluated by detecting the release of H2O2. The expressions of p21, p53, and Nrf2 were measured using the qRT‐PCR and Western blotting assay. siRNA technology was used to knock down the expression level of Nrf2 in SH‐SY5Y neuronal cells.ResultsFirst, it was found that Ramelteon mitigated cell cycle arrest in the G0/G1 phase in 6‐OHDA‐challenged SH‐SY5Y neuronal cells. Second, treatment with Ramelteon alleviated cellular senescence in 6‐OHDA‐treated SH‐SY5Y neuronal cells by increasing telomerase activity and reducing the activity of SA‐β‐gal. It was also found that Ramelteon reduced the expressions of p21 and p53. Notably, Ramelteon attenuated 6‐OHDA‐induced oxidative stress by increasing the expression of Nrf2. Silencing of Nrf2 abolished the protective effects of Ramelteon against 6‐OHDA‐induced cellular senescence. Based on these findings, it was concluded that Ramelteon alleviated 6‐OHDA‐induced cellular senescence by increasing the expression of Nrf2 in human SH‐SY5Y neuronal cells.ConclusionRamelteon protected against 6‐OHDA‐induced cellular senescence in human SH‐SY5Y neuronal cells through activating the Nrf2 signaling pathway.
Community resilience and anxiety among Chinese older adults during COVID‐19: The moderating role of trust in local government
Authors: Zhang Jinfeng , Wang Yan , Zhou Mingjie , Ke Jihong 
Published: July 2021

AbstractThe worldwide spread of COVID‐19 has resulted in an enormous threat to public health, causing global panic, especially older adults suffering severe anxiety due to their vulnerability. With a questionnaire survey on 213 Chinese older adults in April 2020, we examined the role of community resilience in protecting older adults from anxiety during the COVID‐19 pandemic, and simultaneously considered the moderating role of trust in local government. The results indicated that community resilience was negatively associated with older adults' anxiety, and this association was weakened for older adults with low trust in local government. This study has implications for intervention designs that combine resilient factors related to communities and local governments to relieve older adults' anxiety during the pandemic. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, Characterization and Anti‐HIV Activity
Authors: Zhao Yanping , Tian Nana , Wang Hongjun , Yan Hong 
Published: July 2021

AbstractAIDS, caused by HIV‐1, is one of the most dangerous infectious diseases in the world. Therefore, it is necessary to develop new drugs with more potent bioactivities, less toxicity and higher tolerability for controlling the viral load, particularly by using the raw materials that are widely available. Agaricus blazei Murill (AbM), known in China as jisongrong, is of great importance as a food source and as a health‐promoting supplement for immunomodulation. The polysaccharides of AbM exhibit various biological activities, such as regulating cellular immunity and providing anti‐oxidative, anti‐infective, and anti‐inflammatory effects. At present, to our knowledge, no report has explored the chemically sulfated and anti‐HIV‐1 activity of AbM polysaccharides. Herein, the sulfated AbM polysaccharides with different sulfur contents were prepared by the chlorosulfonic acid‐pyridine method. The characteristics of sulfated derivatives were established by the determination of the sulfur content, the relative molecular weight, and the Fourier‐transform infrared spectroscopy. The anti‐HIV activities of the sulfated AbM polysaccharides were evaluated by CCK‐8 and the single‐cycle pseudovirus infection (TZM‐bl) assay. The sulfated AbM polysaccharides had strong antiviral properties, and the half‐maximal inhibitory concentrations approached that of the positive control, azidothymidine. Sulfated modification of AbM polysaccharides can increase their anti‐HIV pharmacological activity, which makes them promising alternative candidates as bioactive macromolecules for biomedical applications in HIV/AIDS.
Ectopic pregnancy of the fundal myometrium in a patient with tuberous sclerosis
Authors: Sharma Neha , Agustin Michele , Polonsky Ariel , Bruck Lance 
Published: July 2021

AbstractA myometrial ectopic pregnancy is a rare and potentially fatal diagnosis. This diagnosis should be considered when presented with large increases in serum beta‐hCG with no evidence of an intrauterine pregnancy, particularly with altered myometrium.
Successful treatment of acute promyelocytic leukemia in a patient under hemodialysis with arsenic trioxide
Authors: Hashimoto Akiko , Tanaka Yasuhiro , Ishikawa Takayuki , Shinzato Isaku 
Published: July 2021

AbstractA man with chronic kidney disease (CKD) under hemodialysis was diagnosed with acute promyelocytic leukemia (APL). He received arsenic trioxide as a single agent and achieved complete molecular remission without severe adverse events. Arsenic trioxide (ATO) can be used safely and effectively for APL with CKD.
Response to gefitinib/crizotinib combination in a pulmonary sarcomatoid carcinoma patient harboring concurrent EGFR mutation and MET amplification
Authors: Wang Xiaomeng , Cao Jie , Du Weijiao , Zhang Weihong , Cao Shui 
Published: July 2021

AbstractPulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non‐small cell lung cancer (NSCLC) with an extremely poor prognosis making it a therapeutic challenge. However, the development of genetic variation molecular diagnosis and targeted agents has brought the treatment of such malignancies to the precision era. Co‐existing mutations of EGFR and MET have been reported in NSCLC, but rarely found in PSC. We herein present a rare case of a 74‐year‐old female patient diagnosed with PSC, carrying an activating mutation in exon 21 L858R of EGFR and a concurrent MET amplification prior to treatment. Combined application of gefitinib and crizotinib, inhibitors targeting EGFR and MET, respectively, was prescribed. The patient experienced a partial response and was stable for 9.7 months off therapy. The observation stresses the importance of genetic testing and paves the way for combined targeted strategies in PSC.
Severe peripartum cardiomyopathy complicated by COVID‐19 infection and small intestinal obstruction
Authors: Abdulraheem Ekhlas , Shaikhoun Mazin , Kung David 
Published: July 2021

AbstractCOVID‐19 infection can be a possible trigger for peripartum cardiomyopathy. Multidisciplinary teamwork was crucial for the favorable outcome in our patient. Small bowel strangulation is a rare complication post‐cesarean section.
Mild‐to‐severe poisoning due to Coniummaculatum as toxic herb: A case series
Authors: Boskabadi Javad , Askari Zahra , Zakariaei Zakaria , Fakhar Mahdi , Tabaripour Rabeeh 
Published: July 2021

AbstractConium maculatum toxicity may occur by mistakenly or intentionally eating this plant. Due to muscarinic or nicotinic symptoms associated with this plant toxicity, supportive care and treatment with atropine are urgently important.
Pregnancy complicated by HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP): a case report
Authors: Mori Hiroshi , Shibata Eiji , Kuwazuru Tomoichiro , Uchimura Takayuki , Kondo Emi , Iwanaka Yukio , Yoshino Kiyoshi 
Published: July 2021

AbstractPregnancy was not associated with deterioration of HAM nor was HAM associated with adverse pregnancy outcome in this case. These findings suggest that women with HAM/TSP, even those who use a wheelchair, should not be discouraged from pregnancy.
3‐Hydroxyisobutyryl‐CoA hydrolase deficiency in an infant with developmental delay and high anion gap acidosis
Authors: Saneifard Hedyeh , Mosallanejad Asieh , Fallahzadeh Aida , Sheikhy Ali 
Published: July 2021

AbstractDue to the rarity of this disorder, paying attention to diagnostic clues is important. Low valine formula seems to be effective in improvement of patient's symptoms. Prevention of consanguineous marriage is the best way to prevent this disease.
Barium appendicitis
Authors: Omura Daisuke , Yunoki Naoko , Otsuka Yuki , Nakano Yasuhiro , Hagiya Hideharu , Otsuka Fumio 
Published: July 2021

AbstractWe have presented a case of barium appendicitis, which is a rare complication of barium enema studies. Barium sulfate is used widely for gastrointestinal radiographic studies and is associated with few complications. Clinicians need to be fully aware of this complication.
Morphology Control Endows Palladium‐Indium Nanocatalysts with High Catalytic Performance for Alcohol Oxidation
Authors: You Huaming , Gao Fei , Wang Cheng , Song Tongxin , Li Jie , Wang Xiaomei , Zhang Yangping , Du Yukou 
Published: July 2021

AbstractPd‐based nanomaterials are regarded as good substitutes for Pt‐based nanocatalysts for catalyzing alcohols oxidation. To further improve the catalytic performance and reduce the cost of Pd‐based nanomaterials, morphology control and alloying are effective strategies. Herein, we synthesized PdIn nanocrystals with different morphologies for the electrocatalytic oxidation of ethanol and methanol. Due to the introduction of In, the amount of palladium is reduced, the utilization rate of Pd is increased, and the catalytic activity and stability are improved. PdIn coral‐like flowers composed of many branches showed the best ethanol and methanol oxidation reaction specific activities, which is 3.10‐ and 3.30‐ fold of the commercial Pd/C, respectively. Moreover, PdIn coral‐like flowers also exhibited acceptable stabilities after 400 cycles of successive cyclic voltammetry. In this study, In was successfully introduced into the field of alcohols catalytic oxidation, which provided more choices for the development of catalysts with better electrocatalytic oxidation performance of liquid alcohol fuel.
Chirality induction to achiral molecules by silica‐coated chiral molecular assemblies
Authors: Scalabre Antoine , Okazaki Yutaka , Kuppan Balamurugan , Buffeteau Thierry , Caroleo Fabrizio , Magna Gabriele , Monti Donato , Paolesse Roberto , Stefanelli Manuela , Nlate Sylvain , Pouget Emilie , Ihara Hirotaka , Bassani Dario M. , Oda Reiko 
Published: July 2021

AbstractHybrid silica‐organic nanohelices are used to organize a large variety of nonchiral small organic molecules or inorganic anions to nanometer‐sized assemblies. Such chiral organization of achiral molecules induces chiroptical properties as detected by vibrational or electronic circular dichroism (CD), as well as from circularly polarized luminescence (CPL).
Nozzle Cavitation and Rock Erosion Experiments Reveal Insight into the Jet Drilling Process
Authors: Jasper Sarah , Gradzki Daniel P. , Bracke Rolf , Hussong Jeanette , Petermann Marcus , Lindken Ralph 
Published: July 2021

AbstractAn in‐depth process analysis of water jetting, a promising cost‐effective drilling method for the exploration of geothermal reservoirs, is presented. The jetting process is analyzed under submerged and pressurized conditions by complementary high‐speed shadow imaging, particle image velocimetry, and rock erosion analysis. The shadowgraphy and velocimetry experiments show that nozzle cavitation dominates the process, and it can be described by a modified cavitation number. Rock erosion experiments show that cloud cavitation governs material erosion. Thus, control of cavitation is essential for the jetting process.
Bischler‐Napieralski Cyclization: A Versatile Reaction towards Functional Aza‐PAHs and Their Conjugated Polymers†
Authors: Li Mengwei , Yuan Yuan , Chen Yulan 
Published: July 2021

AbstractNitrogen atom doped polycyclic aromatic hydrocarbons, the so‐called aza‐PAHs, and their conjugated polymers are applicable as functional chromophores and organic semiconductors. Prosperous developments of PAHs and heterocyclic chemistry have been made possible by considerable improvements in synthetic methodologies, among which one‐step reactions leading directly to an aza‐conjugated ring are highly desirable. Bischler‐ Napieralski cyclization, an old yet efficient reaction, can accomplish this task. During the last ten years, this reaction has been successfully used to synthesize a great variety of aza‐PAHs molecules. Further combination with polymer chemistry is able to provide the corresponding polymers. This feature article summarizes the up‐to‐data advances, mainly achieved by our groups, on the design and synthesis of new and well‐tailored aza‐PAHs and macromolecular architectures using Bischler‐Napieralski cyclization as the key step. Furthermore, the versatile applications of these functional materials in the fields of chemosensors, optoelectronic devices, and biomolecular probes are also covered in detail.
SimpleSync: A parallel delta synchronization method based on Flink
Authors: Zhang Changjian , Qi Deyu , Li Wenlin , Huang Wenhao , Wang Xinyang 
Published: July 2021

AbstractCloud storage service has been in full swing in the industry. Delta synchronization technology as a key technology of cloud storage services has not made a key breakthrough. Almost all the existing researches are based on the synchronization process proposed by the Rsync algorithm and mix some optimization appropriately, but the particularity of cloud storage service is not fully considered. This paper proposes a new incremental synchronization method SimpleSync, which makes use of the characteristic that the server does not actively modify the backup files in the cloud storage service, removes the redundant steps in Rsync, and enables the synchronization between the client and the server only through a single communication. Besides, according to the server‐side synchronization request processing logic, this paper puts forward the design idea of parallel processing with the Flink framework, to the best of our knowledge, for the first time. After the server receives the synchronization request, SimpleSync first puts it into Kafka for buffering and then uses Flink to process the synchronization request in parallel. In the experimental part, a large number of experiments are designed to compare SimpleSync with other delta synchronization algorithms. Experimental results show that SimpleSync has obvious advantages in synchronization performance. Meanwhile, experiments show that SimpleSync has correctness.
Designing new learning environments: An innovative pedagogical perspective
Authors: Sasson Irit , Yehuda Itamar , Miedijensky Shirley , Malkinson Noam 
Published: July 2021

AbstractGiven growing systemic investment in the designing of new learning spaces, researching the relationships between physical space and learning and teaching processes is imperative. Researching innovative learning spaces is challenging, therefore the aim of this paper is to demonstrate a pedagogical characterization based on a three‐dimensional theoretical framework. The study presented here includes three schools in the process of implementing a constructivist pedagogical change involving gradual development of educational intiatives including the redesigning of learning spaces. We characterized learning environments by space, pedagogical practices and curricular potential and explored the relationships between space, active learning and the development of high‐order thinking skills (HOT). Characterization of teaching and learning processes was based on interviews with 12 teachers, 478 class observations and analysis of 307 learning tasks. The findings indicate a higher expression of active learning in the innovative learning spaces compared with the traditional spaces. Nevertheless, results demonstrated difficulties in designing constructivist learning tasks and developing HOT skills, with relatively low encouragement for problem solving skills and critical thinking. Learning tasks were characterized by low cognitive complexity. This study provides a new methodology for investigating teaching and learning processes in innovative learning spaces.
Limitations of VS38c labeling in the detection of plasma cell myeloma by flow cytometry
Authors: Czeti Ágnes , Szalóki Gábor , Varga Gergely , Szita Virág Réka , Komlósi Zsolt István , Takács Ferenc , Márk Ágnes , Timár Botond , Matolcsy András , Barna Gábor 
Published: July 2021

AbstractPlasma cell myeloma (multiple myeloma [MM]) is a malignant neoplasm originating from the plasma cells. Besides other methods, flow cytometric analysis of the patient's bone marrow aspirate has an important role in the diagnosis and also in the response assessment. Since the cell surface markers, used for identifying abnormal plasma cells, are expressed diversely and the treatment can also alter the phenotype of the plasma cells, there is an increasing demand for new plasma cell markers. VS38c is a monoclonal antibody that recognizes the CLIMP‐63 protein in the membrane of the endoplasmic reticulum. CLIMP‐63 is known to be expressed at high levels in normal and pathologic plasma cells in the bone marrow, thus VS38c antibody can be used to identify them. Although VS38c staining of plasma cells is reported to be constant and strong even in myeloma, we were wondering whether sample preparation can affect the staining. We have investigated the effect of different permeabilization agents and washing of the cells on the quality of the VS38c staining and found that in many cases the staining is inadequate to identify the plasma cells. We measured the VS38c staining of the bone marrow aspirates of 196 MM patients and observed that almost all cases showed bright staining with VS38c. However, permeabilization with mild detergent resulted in the appearance of a significant VS38cdim subpopulation, which showed increased sensitivity to mechanical stress (centrifugation). Our results indicate that VS38cdim MM cells can appear due to the improper permeabilization of the endoplasmic reticulum and this finding raises the possibility of the existence of a plasma cell subpopulation with different membrane properties. The significance of this population is unclear yet, but these cells can be easily missed with VS38c staining and can be lost due to centrifugation‐induced lysis during sample preparation.
Evaluation of a two‐season banding program to estimate and model migratory bird survival
Authors: Devers Patrick K. , Emmet Robert L. , Boomer G. Scott , Zimmerman Guthrie S. , Royle J. Andrew 
Published: July 2021

AbstractThe management of North American waterfowl is predicated on long‐term, continental‐scale banding implemented prior to the hunting season (i.e., July–September) and subsequent reporting of bands recovered by hunters. However, single‐season banding and encounter operations have a number of characteristics that limit their application to estimating demographic rates and evaluating hypothesized limiting factors throughout the annual cycle. We designed and implemented a two‐season banding program for American Black Ducks (Anas rubripes), Mallards (A. platyrhynchos), and hybrids in eastern North America to evaluate potential application to annual life cycle conservation and sport harvest management. We assessed model fit and compared estimates of annual survival among data types (i.e., pre‐hunting season only [July–September], post‐hunting season only [January–March], and two‐season [pre‐ and post‐hunting season]) to evaluate model assumptions and potential application to population modeling and management. There was generally high agreement between estimates of annual survival derived using two‐season and pre‐season only data for all age and sex cohorts. Estimates of annual survival derived from post‐season banding data only were consistently higher for adult females and juveniles of both sexes. We found patterns of seasonal survival varied by species, age, and to a lesser extent, sex. Hunter recovered birds exhibited similar spatial distributions regardless of banding season suggesting banded samples were from the same population. In contrast, goodness‐of‐fit tests suggest this assumption was statistically violated in some regions and years. We conclude that estimates of seasonal and annual survival for Black Ducks and Mallards based on the two‐season banding program are valid and accurate based on model fit statistics, similarity in survival estimates across data and models, and similarities in the distribution of recoveries. The two‐season program provides greater precision and insight into the survival process and will improve the ability of researchers and managers to test competing hypotheses regarding population regulation resulting in more effective management.
Decomposing Spatial β‐Diversity in the temperate forests of Northeastern China
Authors: Yu Changtuan , Fan Chunyu , Zhang Chunyu , Zhao Xiuhai , Gadow Klaus von 
Published: July 2021

Abstractβ‐Diversity, which describes the extent of change in species composition in a given region, has become a core issue in ecology in recent years. However, it is hard to understand the underlying mechanisms of β‐diversity by using indices that yield identical values under species replacement and nestedness pattern. Partitioning β‐diversity into turnover (caused by species replacement among plots) and nestedness components (caused by species loss or gain among plots) may provide improved understanding of the variation in species composition. Here, we collected presence–absence data of 456 one‐tenth ha circular plots in the temperate forests of Northeastern China spanning a latitudinal range of 12° (41–53°N). We decomposed β‐diversity to assess the relative contribution of the turnover and nestedness components across latitudinal gradients. We used regression analysis to assess the relationship between spatial distance and β‐diversity. We applied variation partitioning to evaluate the importance of the measured environmental and spatial variables in explaining β‐diversity. We used the Tukey honest significant difference test to test the differences of β‐diversity along latitudinal gradients. Pearson correlations (r) and significance (p‐value) were computed using the Mantel tests to verify the relationship between distance and β‐diversity. The ANOVA test was used to verify whether the variation of β‐diversity explained by the environment and distance was significant. Our results showed that (1) β‐diversity and the turnover component were higher at low latitudes (zones A and B) than at high latitudes (zones C and D), while there was no relationship between the nestedness component and latitude. (2) The turnover component was dominant. (3) The spatial distance explained more variation of β‐diversity than the measured environmental factors. Therefore, we conclude that β‐diversity is mainly a product of species turnover in our temperate forests, suggesting that different localities harbor different species. We find that decomposing β‐diversity into the turnover and nestedness components is a useful approach to explore the variation of community composition and their causes.