bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac late effects after modern 3D-conformal radiotherapy in breast cancer patients: a retrospective cohort study in Germany (ESCaRa)
Authors: Merzenich Hiltrud , Baaken Dan , Schmidt Marcus , Bekes Inga , Schwentner Lukas , Janni Wolfgang , Woeckel Achim , Bartkowiak Detlef , Wiegel Thomas , Blettner Maria , Wollschläger Daniel , Schmidberger Heinz 
Published: October 2021

Abstract
Purpose
Radiotherapy (RT) was identified as a risk factor for long-term cardiac effects in breast cancer patients treated until the 1990s. However, modern techniques reduce radiation exposure of the heart, but some exposure remains unavoidable. In a retrospective cohort study, we investigated cardiac mortality and morbidity of breast cancer survivors treated with recent RT in Germany.

Methods
A total of 11,982 breast cancer patients treated between 1998 and 2008 were included. A mortality follow-up was conducted until 06/2018. In order to assess cardiac morbidity occurring after breast cancer treatment, a questionnaire was sent out in 2014 and 2019. The effect of breast cancer laterality on cardiac mortality and morbidity was investigated as a proxy for radiation exposure. We used Cox Proportional Hazards regression analysis, taking potential confounders into account.

Results
After a median follow-up time of 11.1 years, there was no significant association of tumor laterality with cardiac mortality in irradiated patients (hazard ratio (HR) for left-sided versus right-sided tumor 1.09; 95% confidence interval (CI) 0.85–1.41). Furthermore, tumor laterality was not identified as a significant risk factor for cardiac morbidity (HR = 1.05; 95%CI 0.88–1.25).

Conclusions
Even though RT for left-sided breast cancer on average incurs higher radiation dose to the heart than RT for right-sided tumors, we found no evidence that laterality is a strong risk factor for cardiac disease after contemporary RT. However, larger sample sizes, longer follow-up, detailed information on individual risk factors and heart dose are needed to assess clinically manifest late effects of current cancer therapy.
Genome-wide SNP analysis of three moose subspecies at the southern range limit in the contiguous United States
Authors: Ferrante Jason A. , Smith Chase H. , Thompson Laura M. , Hunter Margaret E. 
Published: October 2021

AbstractGenome-wide evaluations of genetic diversity and population structure are important for informing management and conservation of trailing-edge populations. North American moose (Alces alces) are declining along portions of the southern edge of their range due to disease, species interactions, and marginal habitat, all of which may be exacerbated by climate change. We employed a genotyping by sequencing (GBS) approach in an effort to collect baseline information on the genetic variation of moose inhabiting the species’ southern range periphery in the contiguous United States. We identified 1920 single nucleotide polymorphisms (SNPs) from 155 moose representing three subspecies from five states: A. a. americana (New Hampshire), A. a. andersoni (Minnesota), and A. a. shirasi (Idaho, Montana, and Wyoming). Molecular analyses supported three geographically isolated clusters, congruent with currently recognized subspecies. Additionally, while moderately low genetic diversity was observed, there was little evidence of inbreeding. Results also indicated > 20% shared ancestry proportions between A. a. shirasi samples from northern Montana and A. a. andersoni samples from Minnesota, indicating a putative hybrid zone warranting further investigation. GBS has proven to be a simple and effective method for genome-wide SNP discovery in moose and provides robust data for informing herd management and conservation priorities. With increasing disease, predation, and climate related pressure on range edge moose populations in the United States, the use of SNP data to identify gene flow between subspecies may prove a powerful tool for moose management and recovery, particularly if hybrid moose are more able to adapt.
Out of Sync Subnational Housing Markets and Macroprudential Policies in the UK
Authors: Funke Michael , Mihaylovski Petar , Wende Adrian 
Published: October 2021

AbstractWe examine whether regionally differentiated macroprudential policies can address financial stability concerns and moderate house price differences in the UK. We disaggregate both the household sector and the housing stock in a two-region DSGE model with out of sync subnational housing markets and compare four policy types: standard monetary policy, leaning against the wind monetary policy, national macroprudential policy or one that targets region-specific LTV ratios. In terms of reducing variances of house prices, regionally differentiated macroprudential policy performs best, provided the policy authorities are concerned with stabilising output and house prices rather than simply minimising the variance of inflation.
Organizational Learning for Intelligence Amplification Adoption: Lessons from a Clinical Decision Support System Adoption Project
Authors: Wijnhoven Fons 
Published: October 2021

AbstractIntelligence amplification exploits the opportunities of artificial intelligence, which includes data analytic techniques and codified knowledge for increasing the intelligence of human decision makers. Intelligence amplification does not replace human decision makers but may help especially professionals in making complex decisions by well-designed human-AI system learning interactions (i.e., triple loop learning). To understand the adoption challenges of intelligence amplification systems, we analyse the adoption of clinical decision support systems (CDSS) as an organizational learning process by the case of a CDSS implementation for deciding on administering antibiotics to prematurely born babies. We identify user-oriented single and double loop learning processes, triple loop learning, and institutional deutero learning processes as organizational learning processes that must be realized for effective intelligence amplification adoption. We summarize these insights in a system dynamic model—containing knowledge stocks and their transformation processes—by which we analytically structure insights from the diverse studies of CDSS and intelligence amplification adoption and by which intelligence amplification projects are given an analytic theory for their design and management. From our case study, we find multiple challenges of deutero learning that influence the effectiveness of IA implementation learning as transforming tacit knowledge into explicit knowledge and explicit knowledge back to tacit knowledge. In a discussion of implications, we generate further research directions and discuss the generalization of our case findings to different organizations.
Handgrip Strength Features in Rheumatoid Arthritis Patients Assessed Using an Innovative Cylindrical-Shaped Device: Relationships With Demographic, Anthropometric and Clinical Variables
Authors: Salaffi Fausto , Carotti Marina , Farah Sonia , Ceccarelli Luca , Di Carlo Marco 
Published: October 2021

AbstractTo investigate the relationship between handgrip strength (HGs) features, evaluated with an innovative cylindrical-shaped grip device, and demographic, anthropometric and clinical variables, in patients with rheumatoid arthritis (RA). Consecutive RA patients were prospectively enrolled for this cross-sectional study. For each patient were collected demographic, anthropometric, clinical data related to disease activity. HGs was assessed in terms of area under the force–time curve (AUC-FeT), peak grip force and time to reach the curve plateau. The correlations between the variables were studied with the Spearman’s rho correlation coefficient. The receiver operating characteristic (ROC) curve analysis was used to test the discriminant accuracy of HGs features in identifying patients in moderate/high disease activity. A multivariate analysis was performed to estimate the contribution of covariates on the AUC-FeT. A significant correlation was found among AUC-FeT, age, Simplified Disease Activity Index (SDAI), Ultrasound-Clinical Arthritis Activity (US-CLARA) (all at p < 0.0001), and body mass index (BMI) (p = 0.0001). Any correlation was found between HGs and radiographic damage. The discriminatory power of AUC-FeT was good [area under-ROC curve = 0.810 (95% CI 0.746–0.864)]. Variables significantly associated with AUC-FeT in multivariate analysis were age (p = 0.0006), BMI (p = 0.012), gender (p = 0.004), SDAI (p = 0.047) and US-CLARA (p = 0.023). HGs is negatively influenced by demographic (gender and age), anthropometric (BMI), and disease activity variables (SDAI and US-CLARA). These findings highlight the role of HGs in RA patients' functional impairment and disability.
Effect of new crystalline phase on the ionic conduction properties of sodium perchlorate salt doped carboxymethyl cellulose biopolymer electrolyte films
Authors: Shetty Supriya K , Ismayil  , Noor I. M. 
Published: October 2021

AbstractDopant induced modifications in the microstructure of sodium carboxymethyl cellulose (NaCMC) were characterized by FTIR, XRD, DSC and EIS techniques. FTIR analysis exhibited a considerable microstructural modification in NaCMC upon NaClO4⋅H2O doping invoked through complex formation via Lewis acid-base interaction and hydrogen bond formation between ions and dipoles. This resulted in the modification in the orderliness/disorderliness of polymer chains as observed from XRD deconvolution. At higher salt concentrations, the complexity of the network causes the formation of new amorphous and crystalline phases as reflected in the XRD studies. DSC analysis showed an increase in Tg as the salt concentration increased, indicating a reduction in polymer chains flexibility. The contribution of free ions has masked over the enhancement in amorphous content to conductivity at a lower concentration of salt in the matrix, later on, the formation of a new crystalline phase due to transient crosslinks by Na+…ClO4−…Na+ has affected the ion transport process.
Surface and optical properties of ethylene glycol-based nanofluids containing silicon dioxide nanoparticles: an experimental study
Authors: Traciak Julian , Sobczak Jolanta , Kuzioła Rafał , Wasąg Joanna , Żyła Gaweł 
Published: October 2021

AbstractIn this paper, the results of the experimental study on density, surface tension and optical properties of ethylene glycol-based nanofluids containing silicon dioxide have been presented. The nanofluid-air surface tension values were determined in the temperature range from 283.15 K to 318.15 K with Du Noüy ring method with the commercial equipment and self-made station. To determine the surface tension of a fluid, the information about its density is required; therefore, density of all examined nanofluids was measured in the same temperature range, and results were summarized in the paper. The refractive index of SiO$$_2$$

2

-EG nanofluids was determined in the same temperature range in which the surface tension was examined. Finally, the extinction (UV–Vis spectra) of these materials was examined and presented.
Microwave heating of water–ethanol mixtures
Authors: Schiraldi Alberto , Paoli Alberto 
Published: October 2021

AbstractA simple measure of the susceptibility of a substance to microwaves (MW) is the resulting heating rate that depends on its heat capacity, density, starting temperature, MW extinction coefficient at the used MW frequency and distance from the irradiated surface. Water, that is ubiquitous in many products, currently treated with MW, shows a large susceptibility at 2450 MHz MW. This is why water is a suitable reference to rank the MW susceptibility of other compounds. Aqueous solutions are the simplest systems to investigate how the presence of extra compounds can modify (normally, reduce) this property. The present work provides a very simple evidence of a peculiar MW susceptibility of the water–ethanol mixture with azeotropic composition, XEtOH = 0.90 mol fraction, at temperatures rather below the respective boiling point at ambient pressure. The available literature reports a number of experimental and theoretical investigations that suggest the formation of (EtOH)n·(H2O)m ring clusters that change the hydrogen bond network and/or favor intermolecular hydrophobic hydration. The decamer, (EtOH)9·H2O, could be responsible for the peculiar MW susceptibility of the azeotropic mixture.
The inulin hydrolysis by recombinant exo-inulinases: determination the optimum temperatures and activation energies
Authors: Miłek Justyna 
Published: October 2021

AbstractThe advantages of recombinant enzymes over native include the control in a production environment, product purity and also high yield. The paper presents the determination the optimum temperatures and the activation energies for various origin recombinant exo-inulinases, among others from Aspergillus niger, A. awamori, Kluyveromyces marxianus and K. cicerisporus. The parameters were estimated based on the literature of the activity curves versus temperature for hydrolysis of inulin. It was assumed that both the hydrolysis reaction process and the deactivation process of recombinant exo-inulinase were first-order reactions by the enzyme concentration. A mathematical model describing the effect of temperature on recombinant exo-inulinase activity was used. Based on the comparison analysis, values of the activation energies $${E_{\rm a }}$$

E
a

were in the range from $${32.01 \pm 7.80}$$

32.01
±
7.80

to $${43.83 \pm 4.87}$$

43.83
±
4.87

kJ mol$$^{-1}$$

-
1

, the deactivation energies $${E_{\rm d }}$$

E
d

were in the range from $${83.93 \pm 4.82}$$

83.93
±
4.82

to $${352.44 \pm 14.26}$$

352.44
±
14.26

kJ mol$$^{-1}$$

-
1

and the optimum temperature $${T_{\rm opt }}$$

T
opt

were obtained in the range from $${318.91 \pm }$$

318.91
±

1.19 to $${328.76 \pm 0.25}$$

328.76
±
0.25

K.
Abortion and the Mission of MCH: Perspectives of MCH and Family Planning Professionals in Health Departments
Authors: Woodruff Katie , Wingo Erin , Berglas Nancy F. , Roberts Sarah C. M. 
Published: October 2021

Abstract
Introduction
Prior research shows that maternal and child health (MCH) and family planning (FP) divisions in health departments (HDs) engage in some abortion-related activities, largely when legally mandated; some agencies also initiate abortion-related activities. Yet little is known about health department MCH/FP professionals’ views on how abortion-related work aligns with their professional mission.

Methods
Between November 2017 and June 2018, we conducted in-depth interviews with 29 MCH/FP professionals working in 22 state and local HDs across the U.S. We conducted inductive thematic analysis to identify themes regarding participants’ professional mission and values in relation to abortion-related work.

Results
Participants described a strong sense of professional mission. Two contrasting perspectives on abortion and the MCH/FP mission emerged: some participants saw abortion as clearly outside the scope of their mission, even a threat to it, while others saw abortion as solidly within their mission. In states with supportive or restrictive abortion policy environments, professionals’ views on abortion and professional mission generally aligned with their overall state policy environment; in states with middle-ground abortion policy environments, a range of perspectives on abortion and professional mission were expressed. Participants who saw abortion as within their mission anchored their work in core public health values such as evidence-based practice, social justice, and ensuring access to health care.

Discussion
There appears to be a lack of consensus about whether and how abortion fits into the mission of MCH/FP. More work is needed to articulate whether and how abortion aligns with the MCH/FP mission.
Molecular dynamics modeling of the Vibrio cholera Na+-translocating NADH:quinone oxidoreductase NqrB–NqrD subunit interface
Authors: Dibrov Alexander , Mourin Muntahi , Dibrov Pavel , Pierce Grant N. 
Published: October 2021

AbstractThe Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) is the major Na+ pump in aerobic pathogens such as Vibrio cholerae. The interface between two of the NQR subunits, NqrB and NqrD, has been proposed to harbor a binding site for inhibitors of Na+-NQR. While the mechanisms underlying Na+-NQR function and inhibition remain underinvestigated, their clarification would facilitate the design of compounds suitable for clinical use against pathogens containing Na+-NQR. An in silico model of the NqrB–D interface suitable for use in molecular dynamics simulations was successfully constructed. A combination of algorithmic and manual methods was used to reconstruct portions of the two subunits unresolved in the published crystal structure and validate the resulting structure. Hardware and software optimizations that improved the efficiency of the simulation were considered and tested. The geometry of the reconstructed complex compared favorably to the published V. cholerae Na+-NQR crystal structure. Results from one 1 µs, three 150 ns and two 50 ns molecular dynamics simulations illustrated the stability of the system and defined the limitations of this model. When placed in a lipid bilayer under periodic boundary conditions, the reconstructed complex was completely stable for at least 1 µs. However, the NqrB–D interface underwent a non-physiological transition after 350 ns.
Surgical strategies for older patients with glioblastoma
Authors: Barak Tanyeri , Vetsa Shaurey , Nadar Arushii , Jin Lan , Gupte Trisha P. , Fomchenko Elena I. , Miyagishima Danielle F. , Yalcin Kanat , Vasandani Sagar , Gorelick Evan , Zhao Amy Y. , Antonios Joseph , Theriault Brianna Carusillo , Lifton Nathan , Marianayagam Neelan , Omay Bulent , Omay Zeynep Erson , Huttner Anita , McGuone Declan , Blondin Nicholas A. , Corbin Zachary , Fulbright Robert K. , Moliterno Jennifer 
Published: October 2021

Abstract
Objective
While adjuvant treatment regimens have been modified for older patients with glioblastoma (GBM), surgical strategies have not been tailored.

Methods
Clinical data of 48 consecutive patients aged 70 years or older, who underwent surgical resection for GBM with intraoperative ultrasonography (IoUS) alone or combination with intraoperative MRI (IoMRI) at Yale New Haven Hospital were retrospectively reviewed. Variables were analyzed, and comparative analyses were performed.

Results
The addition of IoMRI was not superior to IoUS alone in terms of overall survival (OS) (P = 0.306), Karnofsky Performance Score (KPS) at postoperative 6 weeks (P = 0.704) or extent of resection (P = 0.263). Length of surgery (LOSx), however, was significantly longer (P = 0.0002) in the IoMRI group. LOSx (P = 0.015) and hospital stay (P = 0.025) were predictors of postoperative complications. Increased EOR (GTR or NTR) (P = 0.030), postoperative adjuvant treatment (P < 0.0001) and postoperative complications (P = 0.006) were predictive for OS. Patients with relatively lower preoperative KPS scores (<70) showed significant improvement at postoperative 6 weeks (P<0.0001). Patients with complications (P = 0.038) were more likely to have lower KPS at postoperative 6 weeks.

Conclusions
Aggressive management with surgical resection should be considered in older patients with GBM, even those with relatively poor KPS. The use of ioMRI in this population does not appear to confer any measurable benefit over ioUS in experienced hands, but prolongs the length of surgery significantly, which is a preventable prognostic factor for impeding care.
Regional differences in cognitive dissonance in evacuation behavior at the time of the 2011 Japan earthquake and tsunami
Authors: Kono Tatsuhito , Okuno Masaya , Yamaura Kazuho 
Published: October 2021

AbstractThis paper constructs an evacuation decision-making model that takes cognitive dissonance into consideration. The purpose of this construction is to clarify the psychological mechanism for the evacuation behavior of residents during an emergency, based on Akerlof and Dickens (Akerlof and Dickens Am Econ Rev 72:307–319, 1982) "The economic consequences of cognitive dissonance". Specifically, we empirically explore people’s psychological mechanism (e.g., cognitive dissonance) for evacuation behavior when a tsunami disaster occurs. As a result, we show that the level of anxiety depends on the area where residents live and that the average anxiety of residents is mostly correlated with the level of damage of past disasters, and that it is affected also by the ages of residents. Since the level of anxiety largely affects an individual’s evacuation behavior, this result can indicate for what kinds of people intervention and assistance are required based on the level of anxiety. A high level of anxiety basically promotes evacuation. Since our results show that anxiety is increased by the experience of tsunamis, education having people virtually experience tsunamis may increase evacuation rates efficiently.
The Search for Meaning in Life Through Continuing and/or Transforming the Bond to a Deceased Spouse in Late Life
Authors: Vähäkangas Auli , Saarelainen Suvi-Maria , Ojalammi Jonna 
Published: October 2021

AbstractBereavement is an ongoing process of negotiation and meaning-making in which widows and widowers make sense of the changed nature of their relationship with their deceased spouse. We analyzed the experiences of meaning in life among older widows and widowers (aged 65+) using interpretative phenomenological analysis (IPA; see Smith et al. in Interpretative phenomenological analysis: Theory, method and research, Sage, 2009), with the following question: How do widows and widowers search for meaning through continuing and/or transforming their bond to their deceased spouse? The results demonstrate that some of the widowed persons sought meaning through rituals or various means of after-death communication with their deceased spouses. Other participants transformed the bond, for example, through clearing out their deceased spouse’s belongings or a process of reconciliation. Many continued and transformed the bond simultaneously, which shows that negotiation of the relationship after the death of a spouse is an ongoing process in which both continuity and change are present. The experience of a violation of meaning in life affected the participants’ capacity to continue their bond with their deceased spouse.
An analysis of top author citations in software engineering and a comparison with other fields
Authors: Petersen Kai , Ali Nauman Bin 
Published: October 2021

AbstractIoannidis et al. provided a science-wide database of author citations. The data offers an opportunity to researchers in a field to compare the citation behavior of their field with others. In this paper, we conduct a systematic analysis of citations describing the situation in software engineering and compare it with the fields included in the data provided by Ioannidis et al. For comparison, we take the measures used by Ioannidis into consideration. We also report the top-scientists and investigate software engineering researchers’ activities in other fields. The data was obtained and provided by Ioannidis et al. based on the Scopus database. Our method for analysis focuses on descriptive statistics. We compared software engineering with other fields and reported demographic information for the top authors. The analysis was done without any modifications to the ranking. In the later analysis, we observed that 37% of researchers listed as software engineers were not in the software engineering field. On the other hand, the database included a large portion of top authors (ca. 60% to 80%) identified in other software engineering rankings. Other fields using the database are advised to review the author lists for their fields. Our research’s main risk was that researchers are listed that do not belong to our studied field.