bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative estimation of hydroxychloroquine sulphate in pharmaceutical dosage form by FT-IR spectroscopy
Authors: Gupta Krishna R. , Masne Tejaswini P. , Rangari Shyam W. , Umekar Milind J. 
Published: December 2024

A novel, cost-effective infrared spectroscopic method has been developed for the quantitative estimation of hydroxychloroquine sulphate in bulk and tablet dosage forms. The analysis was performed using attenuated total reflectance (ATR) sampling method in FTIR. The linearity range of the proposed methods were determined to be in the range of 5-45 µg. The percent assay by proposed methods were found to be 100.01±0.0008. Te recoveries from the proposed methods were found to be 99.90 ± 0.008 (by area method) and 100.09 ± 0.007 (by absorption intensity method). The proposed methods were successfully applied for the determination of hydroxychloroquine sulphate in pharmaceutical tablets The proposed methods were validated according to the guidelines set by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH). The results demonstrated that the proposed methods are accurate, precise, and reproducible (with a relative standard deviation of less than 2 %). Additionally, these methods are simple, cost-effective, and requires less time compared to other available methods. They can be effectively utilized for the estimation of hydroxychloroquine sulphate in various dosage forms.
Mistrz i uczeń. Władysław Tatarkiewicz oraz Bolesław Miciński
Authors: Zajączkowski Ryszard 
Published: December 2024

W artykule omówione zostały intelektualne powinowactwa między wybitnymi przedstawicielami dwóch pokoleń polskich filozofów: Władysławem Tatarkiewiczem i Bolesławem Micińskim. Ten pierwszy już w dwudziestoleciu międzywojennym stał się mistrzem dla wielu młodych polskich intelektualistów. Wpłynął również na Micińskiego, który był jego studentem i asystentem w Uniwersytecie Warszawskim, a zmarł młodo we Francji w 1943 r. Kontakty mistrza i ucznia przypadły na lata 1931-1942. Kultura literacka, historyczno-filozoficzna i estetyczna Tatarkiewicza określiły zainteresowania Micińskiego filozofią francuską XVII wieku (Kartezjusz, Pascal), estetyką oraz Kantem. W tym ostatnim przypadku zaowocowało to słynnym esejem Portret Kanta. Obaj przyjaźnili się ze Stanisławem Ignacym Witkiewiczem (Witkacym). Cenili jego poglądy estetyczne i zasługi teatralne oraz w różny sposób je propagowali. Autor Szewców uważał ich z kolei za autorytety filozoficzne. Pod kierunkiem Tatarkiewicza Miciński studiował i napisał pracę magisterską pt. Rzeczywistość i jej deformacja w sztuce (1936). Świadczy ona o tym, że odziedziczył po mistrzu maestrię analityczną i kulturę logiczną. Cechą jego filozofowania był też semantyzm, a więc przeprowadzanie analiz językowych szczególnie w przypadku pojęć nieokreślonych i niejasnych. Dla obu wzorcem postępowania badawczego była filozofia analityczna. W roku akademickim 1937/1938 Miciński przebywał we Francji, gdzie pracował pod kierunkiem bliskiego Tatarkiewiczowi Jacquesa Chevaliera. Wpływ francuskiego filozofa na Micińskiego wymaga jednak osobnego opracowania.
Słowo i miłość w filozofii Ferdynanda Ebnera i ks. Józefa Tischnera
Authors: Jagiełło Jarosław 
Published: December 2024

Dotychczasowe, nie tylko polskie, opracowania filozofii człowieka, z którymi spotykamy się w dziełach Ferdynanda Ebnera i ks. Józefa Tischnera, jedynie sporadycznie sygnalizują znaczenie antropologiczne i metafizyczne związku słowa i miłości. Tymczasem, w moim przekonaniu, związek ten jest bardzo ważny w przedstawionym przez tych dwóch filozofów źródłowym rozumieniu ludzkiego istnienia jako wydarzania się prawdy bycia człowieka. Dlatego w niniejszym opracowaniu koncentruję się właśnie na opisie tego związku, na tym, jak on funkcjonuje w myśleniu dialogicznym tych dwóch filozofów. Z filozoficznego punktu widzenia jest on godny uwagi przede wszystkim z tej racji, że pokazuje jak tętni życiem filozofia człowieka w swym metafizycznym wymiarze. Inaczej mówiąc, więź słowa i miłości pokazuje, jak istnieje dialogicznie ugruntowana metafizyka człowieka w jej wydarzeniowym charakterze. Słowo i miłość żyją w człowieku jak obiektywne, a zarazem subiektywne, czyli podmiotowe wyrazy jego duchowego życia. Poświęcając uwagę tej problematyce, wskazałem nie tylko na podobieństwa antropologii tych dwóch filozofów, lecz wykazałem przede wszystkim, że wyeksponowana przez nich więź słowa i miłości stanowi ważny klucz do odnowienia źródłowego myślenia o człowieku w dobie zachwiania się pewności tego, co najbardziej podstawowe w jego życiu.
Red Dragon (Hylocereus polarizes) Fruit Peel Herbal Tea with The Addition of Cinnamon, Ginger, and Orange Zest
Authors: Abdul Halik  , Fatmawati  , Jannati Tangngisalu  
Published: December 2024

The peel of dragon fruit is a waste. The meat of dragon fruit is the most frequently consumed; the peel is rarely used and is only wasted. The natural antioxidant lycopene may be found in the skin of dragon fruit. Dragon fruit skin can be processed to make herbal tea. This study aims to ascertain the yield, moisture content, and organoleptic testing to produce dragon fruit peel tea and the effects of adding cinnamon, ginger, and lemon zest. The research treatments included lemon zest at 40%, ginger at 14%, and cinnamon at 6% concentrations. Three treatment levels and three replications were employed in the fully randomized design (CRD) for data analysis. According to the study's findings, the best way to treat a dragon fruit peel herbal tea bag that contains 6% cinnamon powder was to know how adding cinnamon, ginger, and lemon zest to the process of making dragon fruit peel tea affects the yield, moisture content, and organoleptic test. According to the respondents' liking, the taste test scored 3.91%, scent 3.88%, and color 4.45% (loved) (liked). Based on SNI 3836.2013 about tea quality criteria, which stipulates that the maximum moisture content included in tea powder is 8%, a yield of 8.64%, and a moisture content of 0.48% satisfy the tea quality requirements.
Keywords: dragon fruit peel, cinnamon, ginger, lemon zest, red dragon fruit peel tea
Vulnerability Level of Small-scale Fishery Enterprises in Central Tapanuli, North Sumatra
Authors: Sitompul Nabila Khairiyah , Wiyono Eko Sri , Solihin Iin 
Published: December 2024

Numerous operational variables constantly threaten small-scale fishery enterprises, increasing vulnerability and the possibility of economic stagnation. The goal of this study was to investigate the vulnerability of small-scale fishery enterprises in Central Tapanuli Regency. The study looked at six aspects of vulnerability: natural, human, physical, financial, social, and institutional. The methodology employed was participative, using interviews, observations, and Likert scale questionnaires. The study's findings revealed that seasonal and weather circumstances were the most significant weaknesses affecting fishery enterprises. Except for the marketing group, which showed a greater degree of vulnerability was visible in terms of institutional supporting and participation by fishermen's groups. Finally, fishery enterprises can improve their resilience by developing business groups and implementing treatments tailored to each group's individual needs. This study proposes technical methods to increase the resilience and sustainability of the region's fisheries enterprises.
Keywords: Central Tapanuli, fisheries business, resilience, vulnerability
Electric vehicle charging stations load impact on the distribution network
Authors: Guia Talal , M’Hamdi Benalia , Khechekhouche Ali 
Published: December 2024

Integrating large numbers of electric vehicles will lead to operational and planning difficulties for distribution networks. The installation of electric vehicle charging stations (EVCS) increases power losses, affects stability, and degrades the reliability of the distribution network, resulting in dissatisfaction among customers. This work describes the impacts of the integration of electric vehicle charging stations on power losses, voltage stability index, and the main reliability indices as a function of the position and size of electric vehicle charging stations. This investigation was carried out on the IEEE 33 bus test system. According to the results, a high concentration of EVs increases peak demand, leading to greater energy losses, adversely affecting stability, and degrading reliability indices of the distribution network. The choice of installation points for EVCS is therefore very important, as some points induce greater energy losses than others and affect stability and reliability more than others. Measures to mitigate the effects of EVCS installation on distribution networks are crucial.
Social media usage determinants across demographic characteristics of mobile network users in Zimbabwe
Authors: Matema Simbarashe Cowen , Kallier-Tar Safura M. , Cant Michael 
Published: December 2024

The study sought to establish the primary determinants of social media usage among mobile network users in Zimbabwe, and how do these determinants vary across different demographic characteristics, including age, gender, education, income, and occupation. A descriptive research design was used in this study. A self-administered face-to-face personal survey was used to collect data from the consumers. The population in this study was made up of mobile consumers of the mobile network providers, Econet, NetOne, and Telecel in Harare Province, aged between 18 and 64 years. Convenience sampling technique, was used to select the mobile network consumers to participate in the study drawn from the three mobile operators. A sample of 384 respondents was chosen for the study. The result indicated that male respondents demonstrated a stronger perception of the effects of social media engagement on social media usage and truthfulness as a determinant of social media usage among the 18 to 25 age group and the 34 to 41 age group was different. Respondents with secondary education only demonstrated stronger perceptions of the effect of perceived usefulness on social media usage than degree holders’ respondents. Formally employed respondents had a stronger perception of the effects of social media influence on social media usage compared to students. The analysis of the study results further indicated that respondents who earned less than $2000 was significantly less than the mean score for the group which earned between $3001- 4000. The study concluded that male consumers have a stronger perception of the effects of social media engagement on social media usage, the consumers in the 18 to 25 age group have stronger perceptions of truthfulness of information, holders of certificates have a stronger perception of the effects of cost effectiveness on social media usage and formally employed consumers have a stronger perception of the effects of social media influence on social media usage compared to students. Creation of social media content helps the mobile network operators to adapt, design and develop social media content specifically targeted to specific ages, gender, occupations, and income levels on social media sites. Mobile network operators can use the results of the study to choose a social media channel that speak to the right demographic consumers who visit their platforms.
Determination of influence factores and stress concentration factor for express strength calculations of single-cut bolted connections of layered composite plates. Message 1
Authors: Rudakov Konstantin , Dyfuchyn Yurii 
Published: December 2024

When designing bolted joints (BJ), it is necessary, in particular, to carry out their verification calculations for strength. At the same time, it is desirable to use express analysis: calculations by simple formulas of sufficient accuracy. For BJ of plates made of layered polymer composite materials (PCM), the problem has not been solved yet.
Objective. To revise, to rethink and structure the formulas for the express calculation of the maximum stress when the hole is in contact with a rigid cylinder (bolt). Carry out a review on contrasting examples of materials and schemes of PCM plate reinforcement, taking into account possible lateral bolt/hole clearances in a practically relevant range, based on previously obtained and new results.
Numerical calculations were carried out using the finite element method (contact problem) for the BJ plate made of laminated PCM. 3D orthotropy of each monolayer was assumed. Several simple express analysis formulas were checked, and their structuring was carried out. The results are summarized in a table, illustrations are given.
Five factores influencing the value of the maximum tensile stress near the hole in the laminated PCM plate are separated. Numerical estimates were obtained that characterize the degree of influence on the stress concentration on the surface of the hole: material characteristics, reinforcement scheme, and bolt/hole gap sizes in the laminated PCM plate, as well as the accuracy of the considered formulas.
A change in the material and scheme of reinforcement of the layered PCM leads to a significant change in the values ​​of the maximum stresses and stress concentration factor (SCF) in the bolt-loaded hole in the cross-section of the plate weakened by the hole. The considered express analysis formulas have insufficient accuracy for contrasting cases of materials and plate reinforcement schemes. Additional research is needed, especially for the reinforcement scheme [φ/-φ]2s at 0<φ<90.
Transforming Correspondence Learning Through Microlearning-Based Media for Vocational High School Students
Authors: Marisofiyati Marisofiyati , Eryanto Henry , Faslah Roni , Swaramarinda Darma Rika , Yuliawan Rahmat , Rasto Rasto , Muhidin Sambas Ali , Latief M. Jamil , Santoso Jarot Tri Bowo 
Published: December 2024

The rapid development of digital technology requires innovative learning media to improve the student learning experience. This study discusses the development of microlearning-based correspondence learning media designed for Vocational High School (SMK) students under the auspices of the Indonesian Association of Scholars and Office Administration Practitioners (Aspapi) in Jakarta area. The main problem in correspondence learning is the limited effective media to increase students' focus and learning independence. Students often have difficulty in structuring sentences when writing letters and are reluctant to think deeply due to the familiarity with informal communication through social media as well as a lack of knowledge of formal correspondence. This research aims to develop microlearning-based learning media in correspondence learning. The method used is Research and Development (R&D) with the Dick & Carey development model, which includes needs analysis to summative evaluation. The respondents in this study are students of Aspapi's partner vocational schools in Jakarta. The results show that microlearning-based learning media significantly increases the effectiveness of correspondence learning. Students demonstrate better comprehension and increased learning independence thanks to concise and directed microlearning content, in accordance with their digital communication habits. Interactive and accessible media design also helps to overcome low literacy competence and student learning motivation. Based on the above findings, it can be concluded that the development of microlearning-based learning media has proven to be an effective solution in overcoming challenges in correspondence learning. This media is able to improve students' writing skills, critical thinking, and learning independence, so similar innovations are recommended to be applied to other administrative and vocational subjects.
Legal Awareness and Practical Approaches to Halalan Thayyiban Compliance
Authors: Rahmatika Sania Dina , Bashori Yudhi Achmad 
Published: December 2024

This study analyzes the understanding and implementation of the halalan thayyiban principle by street vendors in Ponorogo, Indonesia from a legal awareness perspective. Despite its importance in Islamic teaching, initial observations show that many vendors have not fully implemented this standard. Using an empirical law-based qualitative method, data were obtained through interviews, documentation, and observation and then analyzed inductively. The results revealed two categories of understanding: traders who understand halal in terms of substance, method of acquisition, and processing, and traders who equate thayyib with halal. Their strategies to maintain halalan thayyiban include maintaining cleanliness and using ingredients that are believed to be halal, but many have not met formal guidelines such as halal certification. Legal awareness is still low, although legal behaviors such as maintaining cleanliness have been implemented. This study highlights the need for government socialization and education to support traders in understanding and applying the principles of the halalan thayyiban. This research contributes to the development of halal policies in the informal sector and to understanding the role of legal awareness in micro businesses in Indonesia.
Pr and Pfr structures of plant phytochrome A
Authors: Hughes Jon , Nagano Soshichiro , Guan Kaoling , Chen Peng-Yuan , von Stetten David , Song Chen , Barends Thomas , Weiss Manfred , Feiler Christian , Dörner Katerina , de Diego Iñaki , Schubert Robin , Bielecki Johan , Brings Lea , Kim Chan , Han Huijong , Kharitonov   Konstantin , Koliyadu Jayanath , Koua Faisal , Round Ekaterina , Sarma Abhisakh , Sato Tokushi , Kloos Marco , Valerio Joana , Wrona Agnieszka , Schmidt Christina , de Wijn Raphael , Letrun Romain , Mancuso Adrian , Bean Richard , Heyne Karsten , Schulz Joachim 
Published: December 2024

Abstract

Phytochromes are biliprotein photoreceptors widespread amongst microorganisms and ubiquitous in plants where they control developmental processes as diverse as germination, stem elongation and floral induction through the photoconversion of inactive Pr to the Pfr signalling state. Here we report crystal structures of the chromophore-binding module of soybean phytochrome A, including 2.2Å XFEL structures of Pr and Pfr as well as high resolution cryogenic structures of Pr. In the Pfr structure, the chromophore is exposed to the medium, the D-ring remaining α-facial following the likely clockwise photoflip. The chromophore shifts within its pocket, while its propionate side chains, their partners as well as three neighbouring tyrosines shift radically. Helices near the chromophore show substantial shifts that might represent components of the light signal. These changes reflect those in bacteriophytochromes despite their quite different signalling mechanisms, implying that fundamental aspects of phytochrome photoactivation have been repurposed for photoregulation in the eukaryotic plant. (150 words)
Lysine-Specific Demethylase 1 (LSD1) Modulates Hypoxia and Antitumor Immunity Pathways in Triple Negative Breast Cancer
Authors: Iqbal Jabed , Lee Dong Yeul , Hong Jing Han , Guan Peiyong , Lee Bernett , Perna Stefano , Cui Jianzhou , Chen Jin Miao , Yeong Joe Poe Sheng , Tan Puay Hoon , Teh Bin Tean , Lim Johnathan , Lin Chenshi 
Published: December 2024

Abstract

Epigenetic alterations can disrupt gene functions and lead to cellular neoplastic transformation, significantly contributing to cancer initiation and progression, including triple-negative breast cancer (TNBC). Inhibitors of lysine-specific demethylase 1 (LSD1) have shown potential antineoplastic activity, yet their utility as a biomarker and specific roles in TNBC remain underexplored. Utilizing tissue microarrays from 389 TNBC patients at Singapore General Hospital, we performed immunohistochemical analysis of LSD1 and integrated our findings with data from three additional cohorts (TCGA, METABRIC, FUSCC). Our results reveal that elevated LSD1 levels correlate with poorer survival outcomes in TNBC patients. Mechanistically, LSD1 was found to activate HIF-1/VEGFA signaling and impair cell cycle regulation, thus promoting tumor progression. The causal role of LSD1 was validated through functional assays, RNA-sequencing, and ChIP-sequencing on human breast cell lines and patient-derived xenograft organoids. Additionally, employing digital spatial profiling with whole transcriptome analysis, we discovered that LSD1 overexpression dampens immune-cell profiles and anti-tumor immunity pathways. Overall, our findings elucidate the oncogenic role of LSD1 in TNBC, highlighting implications for potential therapeutic avenues to regulate tumor immunity dynamics and improve patient outcomes.
Challenges of Sustainable Food Security in Iran: Using Grounded Theory and AHP
Authors: Asadi Sharareh , Noorivandi Azadeh Noorollah , Ommani Ahmad Reza , Sabouri Mohammad Sadegh 
Published: December 2024

Abstract

The purpose of this research is identifying and prioritize the challenges of sustainable food security in Iran. This research has been conducted from June 2022 to April 2023 to provide a comprehensive, and applied model to understand the challenges through Grounded Theory (GT) and Analytic Hierarchy Process (AHP) in Khouzestan province, Iran. This research is an applied type of research. The data were collected by performing focus group and brain storming techniques with the 35 agricultural experts in this field. Data analysis was done by using MAXQDA12 software in three steps: open, axial and selective coding. The results of this study by GT identified 34 initial codes and seven main following challenges were categorized and by AHP prioritized: low production efficiency and lack of attention to extension of the favorable consumption pattern, lack of facility support and empowerment for the development of agricultural products, failure to monitor production diversity and proper cultivation pattern, little attention to the criteria of sustainable agricultural development in production, lack of attention to the development of transformation and complementary industries and the production of healthy products with a knowledge-based approach, unfavorable economic conditions for access and continued consumption of healthy food and lack of necessary export platforms and lack of monitoring of illegal imports. Finally applied recommendations were presented to reduce the existing challenges.
Bibliometric analysis of extracellular vesicles in osteoarthritis
Authors: Liao Ga , XIe Hongyu , Kang Lunwei , Zhao Lin , Meng Weikun 
Published: December 2024

Abstract

Osteoarthritis (OA) is a common degenerative joint disease with complex risk factors and an unclear pathogenesis. The onset is insidious, with mild early symptoms, and the disease progression is irreversible. Current treatment options cannot completely cure the disease. Therefore, the development of novel therapeutic approaches and early prevention strategies is crucial for alleviating the disease burden and enhancing the quality of life for patients with OA. Extracellular vesicles (EVs) naturally possess biocompatibility and low immunogenicity, showing significant potential in drug delivery and cell-free therapy. To comprehensively understand the research status and application prospects of EVs in OA, this review employs bibliometric methods to explore the development and collaboration patterns within this research field, current significant research statuses, and emerging directions. Additionally, it thoroughly reviews the mechanisms of EVs in OA, and the integration of EVs with engineering technologies and biomaterials to enhance their efficacy in OA treatment. The goal is to provide scientific evidence and references for the development of OA therapies and the clinical application of EVs.