bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of endothelium function by fatty acids
Authors: Mallick Rahul , Duttaroy Asim K. 
Published: September 2021

AbstractThe endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system by balancing vasodilation and vasoconstriction, modulating the several responses and signals. Plasma lipids can interact with endothelium via different mechanisms and produce different phenotypes. Increased plasma-free fatty acids (FFAs) levels are associated with the pathogenesis of atherosclerosis and cardiovascular diseases (CVD). Because of the multi-dimensional roles of plasma FFAs in mediating endothelial dysfunction, increased FFA level is now considered an essential link in the onset of endothelial dysfunction in CVD. FFA-mediated endothelial dysfunction involves several mechanisms, including dysregulated production of nitric oxide and cytokines, metaflammation, oxidative stress, inflammation, activation of the renin-angiotensin system, and apoptosis. Therefore, modulation of FFA-mediated pathways involved in endothelial dysfunction may prevent the complications associated with CVD risk. This review presents details as to how endothelium is affected by FFAs involving several metabolic pathways.
Climate change and the different roles of physicians: a critical response to "A Planetary Health Pledge for Health Professionals in the Anthropocene"
Authors: Wiesing Urban 
Published: September 2021

AbstractThe article critically responds to "A Planetary Health Pledge for Health Professionals in the Anthropocene" which was published by Wabnitz et al. in The Lancet in November 2020. It focuses on the different roles and responsibilities of a physician. The pledge is criticised because it neglects the different roles, gives no answers in case of conflicting goals, and contains numerous inconsistencies. The relationship between the Planetary Health Pledge and the Declaration of Geneva is examined. It is argued that the Planetary Health Pledge should have supplemented the Declaration of Geneva instead of changing it.
Association of high adherence to vegetables and fruits dietary pattern with quality of life among Chinese women with early-stage breast cancer
Authors: Lei Yuan-Yuan , Ho Suzanne C. , Kwok Carol , Cheng Ashley , Cheung Ka Li , Lee Roselle , Mo Frankie K. F. , Yeo Winnie 
Published: September 2021

Abstract
Purpose
Dietary intake and patients’ quality of life (QoL) are important supportive care issues in breast cancer survivorship. This study aimed to identify dietary pattern before and after breast cancer diagnosis. In addition, the association between dietary patterns and QoL were cross-sectionally and longitudinally investigated.

Methods
A breast cancer cohort which included 1462 Chinese women were longitudinally interviewed at four time-points, namely baseline, 18-, 36-, and 60 months after diagnosis. At each follow-up, validated food frequency questionnaires (FFQ) were used to assess patients’ dietary intake, and factor analysis was used to derive dietary patterns. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) were used to measure QoL at each follow-up. This study included 1368, 1226, 1079 and 1095 patients with invasive disease who completed assessment at baseline, 18-, 36- and 60-month follow-up and had detailed data of dietary intake and QoL.

Results
Based on data obtained at 18-month follow-up, two major dietary patterns were identified: “grain and animal food pattern” and “vegetables and fruits pattern”. Similar dietary patterns were obtained at baseline, 36- and 60- month follow-up. Generalized Estimating Equations (GEE) were used to analyze the longitudinal associations between dietary patterns and QoL over the four follow-ups. High intake of grain and animal food was inversely associated with scores for role functioning (B = − 0.744; 95%CI − 0.147 to − 0.017), dyspnea (B = − 0.092; 95%CI − 0.092 to − 0.092) and constipation (B = − 1.355; 95%CI − 2.174 to − 0.536). Vegetables and fruits intake were positively associated with scores for global health status/QoL (B = 1.282; 95%CI 0.545–2.019), physical functioning (B = 0.545; 95%CI: 0.037–1.053), emotional functioning (B = 1.426; 95%CI 0.653–2.200) and cognitive functioning (B = 0.822; 95%CI 0.007–1.637), while inversely associated with scores for nausea and vomiting (B = − 0.382; 95%CI − 0.694 to − 0.071), dyspnea (B = − 0.570; 95%CI − 0.570 to − 0.570), insomnia (B = − 1.412; 95%CI − 2.647 to − 0.177), loss of appetite (B = − 0.722; 95%CI − 1.311 to − 0.132), constipation (B = − 2.028; 95%CI − 2.775 to − 1.281) and diarrhea (B = − 0.929; 95%CI − 1.481 to − 0.377).

Conclusion
This study suggested that high adherence to “grain and animal food pattern” or “vegetables and fruits pattern” was significantly associated with several aspects of QoL. For instance, vegetables and fruits pattern appears to have beneficial effect on global health status/QoL among Chinese breast cancer patients. Prospective follow-up data could further confirm whether a specific dietary pattern has impact on cancer outcomes.
Segmentation of Coronal Features to Understand the Solar EUV and UV Irradiance Variability III. Inclusion and Analysis of Bright Points
Authors: van der Zwaard Rens , Bergmann Matthias , Zender Joe , Kariyappa Rangaiah , Giono Gabriel , Damé Luc 
Published: September 2021

AbstractThe study of solar irradiance variability is of great importance in heliophysics, Earth’s climate, and space weather applications. These studies require careful identifying, tracking and monitoring of features in the solar photosphere, chromosphere, and corona. Do coronal bright points contribute to the solar irradiance or its variability as input to the Earth atmosphere? We studied the variability of solar irradiance for a period of 10 years (May 2010 – June 2020) using the Large Yield Radiometer (LYRA), the Sun Watcher using APS and image Processing (SWAP) on board PROBA2, and the Atmospheric Imaging Assembly (AIA), and applied a linear model between the segmented features identified in the EUV images and the solar irradiance measured by LYRA. Based on EUV images from AIA, a spatial possibilistic clustering algorithm (SPoCA) is applied to identify coronal holes (CHs), and a morphological feature detection algorithm is applied to identify active regions (ARs), coronal bright points (BPs), and the quiet Sun (QS). The resulting segmentation maps were then applied on SWAP images, images of all AIA wavelengths, and parameters such as the intensity, fractional area, and contribution of ARs/CHs/BPs/QS features were computed and compared with LYRA irradiance measurements as a proxy for ultraviolet irradiation incident to the Earth atmosphere. We modeled the relation between the solar disk features (ARs, CHs, BPs, and QS) applied to EUV images against the solar irradiance as measured by LYRA and the F10.7 radio flux. A straightforward linear model was used and corresponding coefficients computed using a Bayesian method, indicating a strong influence of active regions to the EUV irradiance as measured at Earth’s atmosphere. It is concluded that the long- and short-term fluctuations of the active regions drive the EUV signal as measured at Earth’s atmosphere. A significant contribution from the bright points to the LYRA irradiance could not be found.
Coordinated Multicast/Unicast Transmission on 5G: A Novel Approach for Linear Broadcasting
Authors: Jiménez-Soria David , Martín-Vega Francisco J. , Aguayo-Torres Mari Carmen 
Published: September 2021

AbstractLinear broadcasting services, with a scheduled programming, constitute a paramount telecommunication service for today’s society. Although the existing technology is mature, current linear broadcast systems have serious limitations when providing service to moving users or users placed in areas with complex orography and poor signal quality. To overcome these limitations, 3GPP 5G standard has included a work item to support 5G multicast/broadcast services for future Release 17. This paper investigates the integration of point-to-point (unicast) communication with cellular multicast/broadcast on 5G technology to extend the current support of linear broadcasting services. This integration relies on the use mobile edge computing (MEC) at the 5G base station (gNB) to host a dynamic adaptive streaming over HTTP (DASH) server that is coordinated with the multicast transmission to complement the broadcast service. This approach join the reliability of point-to-point communications, with dedicated resources for each user, with the spectrum efficiency of multi-cast communications, where a set of users share common resources. The cooperation between those unicast and multicast schemes allows those users whose coverage is not good enough, to complete the linear broadcast flow through the point-to-point transmission via MEC. The benefits of such approach have been assessed with simulations in a realistic scenario that considers a vehicle moving across a sparsely populated region in southern Spain. Results reveals that throughput and bitrate playback (reproduction rate) are greatly improved when unicast/multicast integration is enabled since the number of stalling events is reduced significantly.
Design method and verification of a hybrid prosthetic mechanism with energy-damper clutchable device for transfemoral amputees
Authors: Song Majun , Guo Sheng , Oliveira Anderson S. , Wang Xiangyang , Qu Haibo 
Published: September 2021

AbstractTransfemoral amputees (TAs) have difficulty in mobility during walking, such as restricted movement of lower extremity and body instability, yet few transfemoral prostheses have explored human-like multiple motion characteristics by simple structures to fit the kinesiology, biomechanics, and stability of human lower extremity. In this work, the configurations of transfemoral prosthetic mechanism are synthesized in terms of human lower-extremity kinesiology. A hybrid transfemoral prosthetic (HTP) mechanism with multigait functions is proposed to recover the gait functions of TAs. The kinematic and mechanical performances of the designed parallel mechanism are analyzed to verify their feasibility in transfemoral prosthetic mechanism. Inspired by motion—energy coupling relationship of the knee, a wearable energy-damper clutched device that can provide energy in knee stance flexion to facilitate the leg off from the ground and can impede the leg’s swing velocity for the next stance phase is proposed. Its co-operation with the springs in the prismatic pairs enables the prosthetic mechanism to have the energy recycling ability under the gait rhythm of the knee joint. Results demonstrate that the designed HTP mechanism can replace the motion functions of the knee and ankle to realize its multimode gait and effectively decrease the peak power of actuators from 94.74 to 137.05 W while maintaining a good mechanical adaptive stability.
Mussel biology: from the byssus to ecology and physiology, including microplastic ingestion and deep-sea adaptations
Authors: Inoue Koji , Onitsuka Yuri , Koito Tomoko 
Published: September 2021

AbstractMussels are a group of bivalves that includes the dominant species of shallow-sea, freshwater, and deep-sea chemosynthetic ecosystems. Mussels cling to various solid underwater surfaces using a proteinaceous thread, called the byssus, which is central to their ecology, physiology, and evolution. Mussels cluster using their byssi to form “mussel beds,” thereby increasing their biomass per unit of habitat area, and also creating habitats for other organisms. Clustered mussels actively filter feed to obtain nutrients, but also ingest pollutants and suspended particles; thus, mussels are good subjects for pollution analyses, especially for microplastic pollution. The byssus also facilitates invasiveness, allowing mussels to hitchhike on ships, and to utilize other man-made structures, including quay walls and power plant inlets, which are less attractive to native species. Physiologically, mussels have adapted to environmental stressors associated with a sessile lifestyle. Osmotic adaptation is especially important for life in intertidal zones, and taurine is a major component of that adaptation. Taurine accumulation systems have also been modified to adapt to sulfide-rich environments near deep-sea hydrothermal vents. The byssus may have also enabled access to vent environments, allowing mussels to attach to “evolutionary stepping stones” and also to vent chimneys.
In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study
Authors: Kaesler Andreas , Rudawski Freya Lilli , Zander Mark Oliver , Hesselmann Felix , Pinar Isaac , Schmitz-Rode Thomas , Arens Jutta , Steinseifer Ulrich , Clauser Johanna Charlotte 
Published: September 2021

Abstract
Purpose
Extracorporeal membrane oxygenation has gained increasing attention in the treatment of patients with acute and chronic cardiopulmonary and respiratory failure. However, clotting within the oxygenators or other components of the extracorporeal circuit remains a major complication that necessitates at least a device exchange and bears risks of adverse events for the patients. In order to better predict thrombus growth within oxygenators, we present an approach for in-vitro visualization of thrombus growth using real-time X-ray imaging.

Methods
An in-vitro test setup was developed using low-dose anticoagulated ovine blood and allowing for thrombus growth within 4 h. The setup was installed in a custom-made X-ray setup that uses phase-contrast for imaging, thus providing enhanced soft-tissue contrast, which improves the differentiation between blood and potential thrombus growth. During experimentation, blood samples were drawn for the analysis of blood count, activated partial thromboplastin time and activated clotting time. Additionally, pressure and flow data was monitored and a full 360° X-ray scan was performed every 15 min.

Results
Thrombus formation indicated by a pressure drop and changing blood parameters was monitored in all three test devices. Red and white thrombi (higher/lower attenuation, respectively) were successfully segmented in one set of X-ray images.

Conclusion
We showed the feasibility of a new in-vitro method for real-time thrombus growth visualization by means of phase contrast X-ray imaging. In addition, with more blood parameters that are clinically relevant, this approach might contribute to improved oxygenator exchange protocols in the clinical routine.
Regulations Matter: Epistemic Monopoly, Domination, Patents, and the Public Interest
Authors: Meghani Zahra 
Published: September 2021

AbstractThis paper argues that regulatory agencies have a responsibility to further the public interest when they determine the conditions under which new technological products may be commercialized. As a case study, this paper analyzes the US 9th Circuit Court’s ruling on the efforts of the US Environmental Protection Agency (EPA) to regulate an herbicide meant for use with seed that are genetically modified to be tolerant of the chemical. Using that case, it is argued that when regulatory agencies evaluate new technological products, they have an obligation to draw on data, analyses, and evaluations from a variety of credible epistemic sources, and not rely solely or even primarily on the technology developer. Otherwise, they create conditions for their own domination and that of the polity by the technology developer. Moreover, in the interest of advancing the public interest, regulatory agencies must evaluate new technologies in a substantively and procedurally unbiased manner.
Rehabilitation and renovation of cocoa (Theobroma cacao L.) agroforestry systems. A review
Authors: Somarriba Eduardo , Peguero Felipe , Cerda Rolando , Orozco-Aguilar Luis , López-Sampson Arlene , Leandro-Muñoz Mariela E. , Jagoret Patrick , Sinclair Fergus L. 
Published: September 2021

AbstractCocoa farmers must decide on whether to rehabilitate (Rh) or to renovate (Re) a cocoa orchard when its productivity declines due to ageing, disease outbreaks or other causes. Deciding on Rh/Re is often a complex, expensive and conflictive process.In this review, we (1) explore the diversity of contexts, driving forces, stakeholders and recommended management practices involved in Rh/Re initiatives in key cocoa-producing countries; (2) summarise the often conflicting views of farmers and extension agents on Rh/Re programmes; (3) review the evidence of age-related changes in planting density and yield of cocoa, given the weight of these variables in Rh/Re decision processes; (4) describe the best known Rh/Re systems and their most common management practices; (5) propose an agroforestry Re approach that overcomes the limitation of current Rh/Re diagnosis protocols, which do not consider the regular flow of food crop and tree products, and the need to restore site soil quality to sustain another cycle of cultivation of cocoa at the same site; and (6) explore the effects of climate change considerations on Rh/Re decision-making and implementation processes.Each Rh/Re decision-making process is unique and highly context-dependent (household and farm, soil, climate, culture). Tailored solutions are needed for each farmer and context. The analysis, concepts and models presented for cocoa in this paper may also apply to coffee orchards.
Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata
Authors: Geng Chang-An , Deng Zhen-Tao , Huang Qian , Xiang Chun-Lei , Chen Ji-Jun 
Published: September 2021

AbstractTen 3,5-dimethylcoumarins (1–6 and 8‒11) involving six new ones (1–6), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and C. pseudobracteata. The structures of the new compounds were determined by extensive HRESIMS, 1D and 2D NMR spectroscopic analyses. According to the substitution at C-5, these coumarins were classified into 5-methyl, 5-hydroxymethyl, 5-formyl, and 5-nor types. All the isolates were assayed for their inhibition on α-glucosidase, protein tyrosine phosphatase 1B, and T-cell protein tyrosine phosphatase in vitro.
Graphic Abstract
Novel hierarchical structure of MoS2/TiO2/Ti3C2Tx composites for dramatically enhanced electromagnetic absorbing properties
Authors: Du Heng , Zhang Qipeng , Zhao Biao , Marken Frank , Gao Qiancheng , Lu Hongxia , Guan Li , Wang Hailong , Shao Gang , Xu Hongliang , Zhang Rui , Fan Bingbing 
Published: September 2021

AbstractIn order to prevent the microwave leakage and mutual interference, more and more microwave absorbing devices are added into the design of electronic products to ensure its routine operation. In this work, we have successfully prepared MoS2/TiO2/Ti3C2Tx hierarchical composites by one-pot hydrothermal method and focused on the relationship between structures and electromagnetic absorbing properties. Supported by comprehensive characterizations, MoS2 nanosheets were proved to be anchored on the surface and interlayer of Ti3C2Tx through a hydrothermal process. Additionally, TiO2 nanoparticles were obtained in situ. Due to these hierarchical structures, the MoS2/TiO2/Ti3C2Tx composites showed greatly enhanced microwave absorbing performance. The MoS2/TiO2/Ti3C2Tx composites exhibit a maximum reflection loss value of −33.5 dB at 10.24 GHz and the effective absorption bandwidth covers 3.1 GHz (13.9–17 GHz) at the thickness of 1.0 mm, implying the features of wide frequency and light weight. This work in the hierarchical structure of MoS2/TiO2/Ti3C2Tx composites opens a promising door to the exploration of constructing extraordinary electromagnetic wave absorbents.
NUV-pumped luminescence of thermally stable samarium-activated alkali metal borophosphate phosphor
Authors: Fang Zhenyu , Yang Dan , Zheng Youkui , Song Jialiang , Yang Tongsheng , Song Ruitong , Xiang Yuefei , Zhu Jing 
Published: September 2021

AbstractExploring outstanding rare-earth activated inorganic phosphors with good thermostability has always been a research focus for high-power white light-emitting diodes (LEDs). In this study, we report a Sm3+-activated KNa4B2P3O13 (KNBP) powder phase. Its particle morphology, photoluminescence properties, concentration quenching mechanism, thermal quenching mechanism, and chromatic properties are demonstrated. Upon the near-ultraviolet (NUV) irradiation of 402 nm, the powder phase exhibits orange-red visible luminescence performance, originating from typical 4G5/2→6HJ/2 (J = 5, 7, 9) transitions of Sm3+. Importantly, the photoluminescence performance has good thermostability, low correlated color temperature (CCT), and high color purity (CP), indicating its promising application in the NUV-pumped warm white LEDs.
Enabling highly efficient and broadband electromagnetic wave absorption by tuning impedance match in high-entropy transition metal diborides (HE TMB2)
Authors: Zhang Weiming , Dai Fu-Zhi , Xiang Huimin , Zhao Biao , Wang Xiaohui , Ni Na , Karre Rajamallu , Wu Shijiang , Zhou Yanchun 
Published: September 2021

AbstractThe advance in communication technology has triggered worldwide concern on electromagnetic wave pollution. To cope with this challenge, exploring high-performance electromagnetic (EM) wave absorbing materials with dielectric and magnetic losses coupling is urgently required. Of the EM wave absorbers, transition metal diborides (TMB2) possess excellent dielectric loss capability. However, akin to other single dielectric materials, poor impedance match leads to inferior performance. High-entropy engineering is expected to be effective in tailoring the balance between dielectric and magnetic losses through compositional design. Herein, three HE TMB2 powders with nominal equimolar TM including HE TMB2-1 (TM = Zr, Hf, Nb, Ta), HE TMB2-2 (TM = Ti, Zr, Hf, Nb, Ta), and HE TMB2-3 (TM = Cr, Zr, Hf, Nb, Ta) have been designed and prepared by one-step boro/carbothermal reduction. As a result of synergistic effects of strong attenuation capability and impedance match, HE TMB2-1 shows much improved performance with the optimal minimum reflection loss (RLmin) of −59.6 dB (8.48 GHz, 2.68 mm) and effective absorption bandwidth (EAB) of 7.6 GHz (2.3 mm). Most impressively, incorporating Cr in HE TMB2-3 greatly improves the impedance match over 1–18 GHz, thus achieving the RLmin of −56.2 dB (8.48 GHz, 2.63 mm) and the EAB of 11.0 GHz (2.2 mm), which is superior to most other EM wave absorbing materials. This work reveals that constructing high-entropy compounds, especially by incorporating magnetic elements, is effectual in tailoring the impedance match for highly conductive compounds, i.e., tuning electrical conductivity and boosting magnetic loss to realize highly efficient and broadband EM wave absorption with dielectric and magnetic coupling in single-phase materials.