bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the Balance of Aspects of the Socio-Ecological and Economic Efficiency of the Organization Activity Based on the Dynamic Standard Method
Authors: Hruznevich K. S. 
Published: December 2021

In modern conditions, the main goal of the organization activity is not only to obtain a commercial effect in the form of profit, but also its stable development, which depends on the health of people and the quality of the environment. Understanding this forms a new look at the organization only a moderate consumption of resources, the preservation of the natural environment for the sake of future generations can allow it to become effective in the long term. This requires a transition from the traditional economic understanding of efficiency to the socio-ecological and economic one, which is based on the balance of its aspects.The aim of the study is to develop the author’s definitions of the categories “socio-ecological and economic efficiency”, “balance”; as well as an assessment of the balance of aspects of efficiency based on the dynamic standard method. The objectives of the study include: a) to develop the author’s definitions of the categories of socio-ecological and economic efficiency and balance; b) consider approaches to assessing the balance at the micro and meso levels; c) form a system of indicators for assessing the effectiveness of the organization; d) develop a normative series of growth rates of performance indicators and compare with the actual one using the example of a particular organization.Materials and methods. In preparing the article, methodological approaches to assessing the balance at the micro and meso levels were studied, namely: the essence, content, statistical tools underlying them, their shortcomings and the ability to assess the balance of aspects of the effectiveness of the organization activity were identified. The assessment was carried out using the dynamic standard method, for which the normative order of subordination of the indicators included in it was determined. For the assessment, we used data from the industrial organization, the main activity of which is the production of outerwear (Republic of Belarus, Vitebsk region).Results. As a result of writing the paper, the author’s definitions of the studied categories were developed, a system of indicators for certain aspects of the effectiveness of the organization activity was formed, priorities in growth rates were determined and the normative ranks of the selected indicators were established. Based on the data of a specific organization, a comparison was made between the normative and actual modes of functioning based on the calculation of the Spearman’s rank correlation coefficient and Kendall’s rank correlation coefficient. The conclusion is made, theoretical directions of increasing the consistency of tempo characteristics are proposed.Conclusion. The article points out the degree of balance of certain aspects of efficiency (social, environmental and economic) on the example of a real business entity, which made it possible to form theoretical directions for eliminating their imbalance.
Cryptogenic Stroke and Embolic Stroke of Undetermined Source: Risk
Factors and Approaches for Detection of Atrial Fibrillation
Authors: Rakhimova Idaliya , Semenova Yuliya , Khaibullin Talgat , Kuanysheva Anargul , Kovalchuk Vitalii , Abdrakhmanov Ayan 
Published: December 2021

Background:
Stroke is a problem worldwide because of its high mortality and disability
rates. Almost 90% of strokes are ischemic, and more than half of the deaths are caused by an ischemic
stroke. Most risk factors for stroke are manageable so that it can be avoided with proper prevention.
Despite the success in determining the causes of stroke in recent years, selectively, the
“culprit” causing stroke remains unsolved. In such cases, a diagnosis of undetermined etiology
(cryptogenic stroke) or embolic stroke of undetermined source (ESUS) is generated, resulting the
prevention of a recurrent cerebrovascular occurrence impossible. Atrial fibrillation (AF) can be a
cause of stroke by causing blood clots in the chambers of the heart.

Purpose:
The aim was to determine the optimal method of heart rate monitoring in patients with ischemic
stroke, as methods and approaches for detecting AF are very diverse, but there is still no
single opinion, which would be universal.

Procedures:
In our review, we consider epidemiology, risk factors for the stroke of undetermined
etiology, as well as analytical methods for detecting heart rhythm disturbances in this category of
patients.

Findings:
Atrial fibrillation (AF) is detected by thorough monitoring of heart rate of patients with
cryptogenic stroke and ESUS can be diagnosed in up to 46% of patients.

Conclusion:
After AF detection, consideration should be given to prescribing anticoagulants, instead
of antiplatelet agents, for the secondary prevention of stroke.
Potential Protective Effect of Dl-3-n-butylphthalide on Chronic Cerebral
Ischemia Brain Injury
Authors: Zhao Fangfang , Luo Yumin 
Published: December 2021

:
Chronic cerebral ischemia is one of the common ischemic cerebrovascular diseases.
Chronic cerebral ischemia can lead to brain dysfunction, and its pathophysiological mechanism involves
inflammation, blood-brain barrier destruction, oxidative stress, and other factors. As it is difficult
to detect, it is easily overlooked, and it is often only observed following the onset of cognitive
dysfunction. At present, there are only a few drugs for its treatment. Dl-3-n-butylphthalide
(NBP), a compound extracted from celery seed, may play an important role in protecting against
brain damage caused by chronic cerebral ischemia. Therefore, here, we have paid attention to the
prevention and treatment of chronic cerebral ischemia with NBP.
Molecular Modeling, Interacting Residues and other Structural Analyses for Human SOCS3, Gp130 and JAK Proteins: A Detailed Computational Approach for Proteins Involved in Feedback Inhibition
Authors: Banerjee Arundhati , Dasgupta Rakhi 
Published: December 2021

Background:
When STAT3 is activated only by the IL6 family of proteins, then gp130
(having a phosphopeptide motif) interacts with human SOCS3, which further binds to JAK and inhibits
its protein kinase activity. Interaction of gp130 with SOCS3 targets only the IL-6 signaling
cascade. The interaction occurs when SOCS3 binds to a particular motif on gp130 (centered upon
pTyr759) after its phosphorylation. Previously, wet laboratory studies were done, but computational
exploration for the participating residues remained unexplored.

Methodology:
The 3D structure of human SOCS3 protein was modeled, and its stereochemical parameters
were satisfied. Crystallographic structures of gp130-phosphopeptide and JAK were
studied. After protein docking, the complex underwent minimization and molecular dynamics simulation.
Different stability parameters and binding patterns with residues were evaluated.

Results and Discussion :
The best-modeled structure of SOCS3 protein was selected and found that
it had three helices and seven sheets interspersed with coils. Arg133, Tyr137 and Tyr98 from SOCS3
formed manifold binding patterns with gp130 (mainly with pTyr759 and Glu758). Lys62,
Lys63 and Arg65 from SOCS3 were also found to interact with Val762 of gp130. Interactions with
JAK were also studied. Residue 53, 62-65, 98, 133, 136 and 137 formed the predominant binding
pockets in SOCS3. They can serve as important target sites as well. Altogether, it created electrostatically
charged pockets to accommodate the partner proteins for each other. Gp130 phosphopeptide
was observed to be tightly accommodated in the electrostatically positive zones on the SOCS3
surface. Net area for solvent accessibility was also found to get drastically reduced, implying high
participation of residues. Earlier studies documented that the interaction of these three proteins occurs
with affinity and have a satisfactory association with each other.

Conclusion:
Here in this study, the free energy of binding for the triple protein interaction through
the ΔG values helped to infer that SOCS3 interacted spontaneously (in a thermodynamic sense).
Many helical conformations formed coiled-coils providing high flexibility to interact spontaneously.
Most of the interactions were through the responsible SH2 domain (46-127 residue length) of
SOCS3. Residues 53, 62-64 and 98 formed coils while the residue number 137adopted sheet conformation
from coils.

Future Scope:
This study shall instigate blocking the gp130-binding sites of SOCS3 through targeting
of drugs, thereby preventing SOCS3-gp130 interaction. This would allow the JAK-STAT signaling
cascade, which is paramount for several biological functions.
Lithium Plus Olanzapine: One of the Most Effective Combinations
for Bipolar Disorder: A Case Report and a Concise Review
of the Literature
Authors: Rodríguez Aitzol Miguélez , de Mendiola Etxezarraga Xabier Pérez 
Published: December 2021

Background:
The recurrent nature of Bipolar Disorder (BD) is the
main cause of disability associated with the illness. Despite the proliferation of
drugs approved for the maintenance phase of BD, the relapse rate is still high.
The combination of drugs, especially the potentiation of mood-stabilizers with second-
generation antipsychotics, may reduce the risk of relapse and rehospitalization.
However, studies on the efficacy of specific combinations are scarce.

Case presentation:
The clinical case of a 28-year-old woman involuntarily admitted
to an Acute Psychiatric Unit is presented. She suffers a manic postpartum
episode with mixed and psychotic features. During the hospitalization, she is successfully
treated with a combination of lithium plus olanzapine. In the discussion,
a concise narrative review of the scientific literature on the efficacy of such
a combination in BD is made.

Conclusion:
The association of lithium plus olanzapine is one of the combinations
with most evidence on its efficacy in BD, especially in mixed-featured episodes.
Tolerability concerns should not be an obstacle to its use, although they
must be considered.
Condomless Anal Sex Associated With Heterogeneous Profiles Of HIV Pre-Exposure Prophylaxis Use and Sexual Activities Among Men Who Have Sex With Men: A Latent Class Analysis Using Sex Diary Data on a Mobile App
Authors: Yu Yi-Fang , Wu Huei-Jiuan , Ku Stephane Wen-Wei , Huang Po-Hsien , Li Chia-Wen , Huang Poyao , Strong Carol 
Published: December 2021

Background
New innovative technologies, such as mobile apps, have been developed to increase pre-exposure prophylaxis (PrEP) adherence and the use of log sex diaries. The contiguity of mobile apps reduces the recall bias that generally affects reported condom and PrEP use. However, none of the currently used mobile apps were designed for event-driven PrEP users, and few studies have demonstrated the potential usage of sex diary data to facilitate the understanding of the different HIV risks among heterogeneous profiles of sex diaries and PrEP use.

Objective
We aim to discriminate the heterogeneous profiles of sex events and PrEP use and examine the risk of condomless anal sex among different types of sex events.

Methods
We recruited 35 adult men who have sex with men from two medical centers in Taiwan since May 2020 and followed up for four months. Participants were on PrEP or willing to take PrEP. They were asked to log their sex events, PrEP use, and dosing regimens on a mobile app to improve their PrEP adherence. Latent class analysis was used to distinguish profiles of sex events and PrEP use. Indicators included correct intake of PrEP for each sex event, participants’ sexual positioning, partner’s HIV status, and age.

Results
A total of 551 sex events were classified into three classes by latent class analysis: PrEP nonadherent flip-flopping (234/551, 42%), PrEP imperfect-adherent power bottoming (284/551, 52%), and PrEP adherent serodiscordant topping (33/551, 6%). “PrEP nonadherent flip-flopping” sex events were more likely to involve condomless anal sex than “PrEP imperfect-adherent power bottoming” (OR 1.83, 95% CI 1.03-3.25) after considering random intercepts for individuals, and this class needed to increase their PrEP adherence and use of condoms. “PrEP imperfect-adherent power bottoming” realized their own risk and packaged PrEP with condoms to protect themselves. Up to 99% (32/33) of sex events in “PrEP adherent serodiscordant topping” were protected by PrEP, but all of the sex events in this group were condomless.

Conclusions
Using the sex diary data could advance the capacity to identify high-risk groups. HIV prevention strategy should be more flexible and combine PrEP with condom use for future HIV prevention.
Accuracy of Store-and-Forward Teledermatology for the Diagnosis of Skin Cancer: The Nouvelle-Aquitaine Experience
Authors: Bui Colin , Doutre Marie-Sylvie , Taieb Alain , Beylot-Barry Marie , Joseph Jean-Philippe , Dorizy-Vuong Valérie 
Published: December 2021

Background
In Nouvelle-Aquitaine (a French region with a population of almost 6 million), the density of dermatologists is less than 3.8/100,000 inhabitants. This lack of dermatological care is delaying diagnosis and management, especially for skin cancer. The SmartDerm Project is a store-and-forward (SAF) teledermatology platform for primary care in Nouvelle-Aquitaine providing dermatological counselling to general practitioners (GPs).

Objective
The main objective was to determine the concordance between the diagnosis of skin cancer made by dermatologists and the pathologists’ diagnosis.

Methods
GPs in 3 pilot departments of Nouvelle-Aquitaine (Lot-Et-Garonne, Deux-Sèvres, Creuse) sent their dermatology requests using their smartphone, via an app called PAACO/Globule; dermatologists at the University Hospital of Bordeaux answered within 48-72 hours. Consecutive cases of skin cancer suspected by the referent dermatologists during the intervention were included, if the result of biopsy interpreted by a certified pathologist was available at the time of the study.

Results
Among the 1727 requests, 163 (9%) concerned a possible diagnosis of skin cancer and were eligible. For 61 cases, the histopathological findings were not available. Eventually, 93 patients with a total of 102 skin lesions were included. Median age was 75 years (range 26-97 years), with 53% women. The skin lesions had progressed for 8 months on average (range 0.5-36 months). The median response time was 1 day (range 0-61 days); 65 days (range 1-667 days) elapsed on average between the SAF opinion and the histological sample. Histopathology diagnosed 83 malignant lesions (57 basal cell carcinomas, 69%; 18 squamous cell carcinomas, 22%; 6 melanomas, 7%; 1 cutaneous lymphoma, 1%; 1 secondary location of a primary cancer, 1%), 1 precancerous lesion, and 18 benign lesions. The concordance between the opinion of the referent dermatologist and the final pathological finding was 83% for nonmelanocytic lesions and 67% for melanocytic lesions.

Conclusions
This study showed the reliability of SAF teledermatology in the diagnosis of skin cancer, comparable to literature data in the absence of dermatoscopy. The median delay of about two months between request and histology was an improvement compared to the delay of usual appointments in the intervention area. The lack of data for 61 patients showed that SAF telemedicine requires better coordination and follow-up, especially for the management of skin cancer. With this reservation in mind, teledermatology offers an alternative answer for the triage of patients with skin cancer residing in areas with low medical density.

Conflicts of Interest
None declared.
Estudio cualitativo de las funciones adultas. Instrumento de indagación
Authors: Machini Florencia Agustina Candelaria , Arias Patricia Susana 
Published: December 2021

El proyecto de investigación denominado “Uso y validación clínica de un instrumento de indagación para niños en el campo psicológico y psicopedagógico” (PI 29/A394), busca ampliar el instrumento de indagación para niños creado en el proyecto de investigación “La incidencia de modelos enseñantes en niños que aprenden. Diseño de un instrumento para su análisis” para verificar si las propiedades encontradas en las representaciones de los niños sobre los modelos adultos se conservan en el uso clínico individual.
El estudio se centra en las historias individuales de los sujetos profundizando el conocimiento sobre las posiciones subjetivas de enseñantes padres acerca de la función adulta e identificando en los datos provenientes de la información empírica la convergencia de sentidos de nuevas técnicas de indagación complementarias del instrumento ya diseñado y validado en la investigación que antecede.
Perfil de las coordinaciones de las UCDIE1 y su relación con las características del liderazgo pedagógico y el liderazgo para la justicia social
Authors: Ruiz Laura , Schettini Castro María Raquel 
Published: December 2021

El presente trabajo indaga en prácticas que asociamos al liderazgo pedagógico (LP) yliderazgo para la justicia social (LJS) en Uruguay a partir de un estudio exploratoriode las Unidades Coordinadoras Departamentales de Integración Educativa (UCDIE).Tomando algunas competencias que hacen a los liderazgos mencionados y la informaciónrecabada en una serie de entrevistas, se ensaya un esbozo del saber hacer dedichas unidades. Uno de los interrogantes que guían la investigación es el siguiente:¿Responden los perfiles de coordinación de las UCDIE a las características del liderazgopedagógico y de la justicia social?
Las UCDIE son las encargadas de potenciar, a nivel departamental y local, una políticaque apunta a la coordinación metodológica y a la continuidad educativa entre lossubsistemas de la Administración Nacional de Educación Pública (ANEP), así como dedesplegar estrategias y generar acuerdos territoriales en pro de favorecer el derechoa la educación.
Publication Benchmarking Data Based on Faculty Promoted at Institutions Ranked 200+
Authors: Carmack Rodney F. , Moehrle Stephen R. , Moon Jared , Wood David A. 
Published: December 2021

ABSTRACT
Although publication benchmarking studies for accounting faculty have been completed for highly ranked research institutions, there is not comparable data for the hundreds of smaller, less high profile, and less resource rich accounting programs. This study provides data for institutions that rank 200+ in the BYU accounting rankings. We take a sample of 50 institutions from this population to develop publication benchmarking for promotion to associate professor. We also provide insights on the timing of publications relative to promotion dates and compare these results to previous benchmarking studies. These results are useful for faculty at these institutions to inform their research efforts and to inform promotion and other decisions by faculty and administrators.
Data Availability: Contact the authors.
STUDENTS’ RESPONSES TO ENGLISH LEARNING AT SMP MAITREYAWIRA BATAM
Authors: Anton Oey 
Published: December 2021

The research objectives are to explore and describe students’ responses to English learning at SMP Maitreyawira Batam, and to make the relations of substantive theory based students’ responses. This research approach is naturalistic by using open questionnaires. The results show some students feel fun, joyful, enjoying, easier, and have self-encouragement in English learning. Some students feel unenthusiastic, bored, get unknowing purpose, and have the complexity in English learning. Researcher also finds nine substantive theories from four grand categorizations show students’ positive responses; namely (1) Understanding English learning causes students feel fun and joyful, (2) Too many English tasks given affect to students’ obstacles, (3) Being able to communicate with foreigners is a need for students, (4) Less practicing makes the complexity in English learning for students, (5) Presenting material (2013 curriculum) makes some students feel easier, (6) The repeating materials affect students feeling bored, (7) More practicing makes students enjoy English, (8) Unknowing the purpose of English learning cause students feel unenthusiastic and bored, and (9) Noisy classroom give students more difficulties in English learning.Keyword: student response, English learning, substantive theory RESPONS SISWA DALAM PEMBELAJARAN BAHASA INGGRIS DI SMP MAITREYAWIRA BATAMAbstrakTujuan penelitian ini adalah untuk mengeksplorasi dan mendeskripsikan respon siswa terhadap pembelajaran bahasa Inggris di SMP Maitreyawira Batam, dan untuk membuat hubungan antara respon teori berbasis teori substantif. Pendekatan penelitian ini bersifat naturalistik dengan menggunakan kuesioner terbuka. Hasilnya menunjukkan beberapa siswa merasa senang, gembira, menikmati, lebih mudah, dan memiliki dorongan diri dalam belajar bahasa Inggris. Beberapa siswa merasa tidak antusias, bosan, tidak sadar, dan memiliki kompleksitas dalam belajar bahasa Inggris. Peneliti juga menemukan sembilan teori substantif dari empat kategorisasi utama yang menunjukkan tanggapan positif siswa; yaitu (1) Memahami pembelajaran bahasa Inggris menyebabkan siswa merasa senang dan gembira, (2) Terlalu banyak tugas bahasa Inggris yang diberikan pada hambatan siswa, (3) Mampu berkomunikasi dengan orang asing adalah kebutuhan siswa, (4) Kurang berlatih membuat kompleksitas dalam pembelajaran bahasa Inggris untuk siswa, (5) Penyajian materi (kurikulum 2013) membuat beberapa siswa merasa lebih mudah, (6) Materi yang berulang-ulang mengakibatkan siswa merasa bosan, (7) Lebih banyak praktik membuat siswa dapat menikmati bahasa Inggris, (8) Tanpa mengetahui tujuan dari pembelajaran bahasa Inggris menyebabkan siswa merasa tidak antusias dan bosan, dan (9) Kelas yang bising memberi siswa lebih banyak kesulitan dalam belajar bahasa Inggris.Kata kunci: respon siswa, pembelajaran Bahasa Inggris, teori substantif
Capability Assessment Model Development Micro Teaching Music Education Students Jurusan Sendratasik FBS UNP
Authors: Maestro Esy , Ambiyar Ambiyar , Aziz Ishak 
Published: December 2021

This article is written based on research to produce a model and assessment system of teachingpracticeability, which can be utilized Educators and Education. This research was conducted by considering the need: (1) development of teaching practice skills that can improve students' high-level thinkingability, (2) assessment models relevant to learning achievements, (3) implementation of various and feasible assessments for students, as well as (4) the application of learning achievement assessment models and systems taking into account a variety of interests and talents. Data is collected through expert evaluation of teaching ability formulation and teaching ability assessment model and through focus group discussion with staff who are interested in the implementation of assessment. Data/information analysis is done descriptive qualitatively and quantitatively in accordance with the type of data collected. The results stated that the hypothetical model for assessment of teaching practice skills of music education students who demanded theavailabilityof: (1) practical classes and practical exams and labor praktik; (2) mentoring/instructors, examiners, and IT staff with sufficient amount and quality; and (3) guidelines and procedures as a reference for all parties involved in the implementation of the assessment.