bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frank haematuria secondary to ruptured pseudoaneurysm of the inferior vesical artery: a case report and review of the literature
Authors: Suoub Mohammed , Talahmeh Ghassan , Abdelraouf Salah , Sawaqed Fadi 
Published: March 2021

Abstract
Background
Pseudoaneurysm of a vesical artery is an extremely rare iatrogenic complication; however, it may cause fatal haematuria.

Case presentation
A 21-year-old Arab Jordanian male had multiple optical urethrotomies for an iatrogenic urethral stricture after he had rectal surgery for Hirschsprung’s disease at the age of 2 years. During one of his admissions to the Emergency Room (ER) with urinary retention, an attempt at suprapubic catheter insertion was complicated by massive bleeding at the insertion site of the catheter. Abdominal exploration showed a distended urinary bladder with clots and bleeding seen at the bladder neck that was controlled with multiple sutures. The patient rebled again two times; the first was controlled with cystoscopy and cautery for a pulsatile bleeder seen at the bladder neck. The second time, the patient required blood transfusion of three units of packed red blood cells. Angiography was performed, and a pseudoaneurysm at the base of the urinary bladder from the inferior vesical artery was diagnosed, which was controlled by embolization.

Conclusion
Pulsatile bladder haemorrhage following urological intervention is suggestive of pseudoaneurysm or arteriovesical fistula, and angiography with embolization is recommended.
Wild radish (Raphanus sativus var. hortensis f. raphanistroides) root extract protects neuronal cells by inhibiting microglial activation
Authors: Do Moon Ho , Kim Mina , Choi Sang-Yoon , Lee Pyeongjae , Kim Yoonsook , Hur Jinyoung 
Published: March 2021

AbstractExternal stimulus-induced activation of microglia plays an important role in the protection of neurons in the central nervous system; however, over-activation of microglia could cause neuronal damage, and it is implicated in the pathogenesis of neurodegenerative diseases. The aim of the present study was to investigate the effects of wild radish (Raphanus sativus var. hortensis f. raphanistroides) root extract (WRE) on microglial over-activation. Mouse microglia BV-2 cells and rat primary microglia were stimulated with lipopolysaccharide (LPS), treated with WRE, and analyzed for nitric oxide (NO) production, pro-inflammatory cytokine secretion, inducible NO synthase (iNOS) expression, and p38 kinase phosphorylation. Human neuroblastoma SH-SY5Y cells were treated with microglia-conditioned medium and analyzed for cell viability. Stimulation with LPS increased NO production and iNOS expression in BV-2 cells and primary microglia, but the treatment with WRE decreased both. Furthermore, WRE downregulated the mRNA expression and secretion of inflammatory cytokines interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α), and inhibited the phosphorylation of p38 in LPS-activated microglia. Treatment with the conditioned medium of LPS-induced BV-2 cells decreased the viability of SH-SY5Y cells, but the damaging effect was significantly alleviated in cells treated with the conditioned medium of LPS plus WRE-cultured microglia. This indicated that the WRE treatment of microglia could protect neuronal cells from microglial activation-induced neurotoxicity. WRE may be a potential food product to attenuate neuroinflammation via the inhibition of microglial over-activation, which can slow down the neurodegenerative processes in the brain.
Mediators Linking Maternal Weight to Birthweight and Neonatal Fat Mass in Healthy Pregnancies
Authors: Kristiansen Oddrun , Zucknick Manuela , Reine Trine M , Kolset Svein O , Jansson Thomas , Powell Theresa L , Haugen Guttorm , Henriksen Tore , Michelsen Trond M 
Published: March 2021

Abstract

Context
Lifestyle interventions have not efficaciously reduced complications caused by maternal weight on fetal growth, requiring insight into explanatory mediators.

Objective
We hypothesized that maternal mediators, including adiponectin, leptin, insulin, and glucose, mediate effects of pregestational BMI (pBMI) and gestational weight gain (GWG) on birthweight and neonatal fat mass percentage (FM%) through placental weight and fetal mediators, including insulin levels (Ifv) and venous-arterial glucose difference (ΔGfva). Hypothesized confounders were maternal age, gestational age, and parity.

Methods
A cross-sectional study of healthy mother-offspring-pairs (n = 165) applying the 4-vessel in vivo sampling method at Oslo University Hospital, Norway. We obtained pBMI, GWG, birthweight, and placental weight. FM% was available and calculated for a subcohort (n = 84). We measured circulating levels of adiponectin, leptin, glucose, and insulin and performed path analysis and traditional mediation analyses based on linear regression models.

Results
The total effect of pBMI and GWG on newborn size was estimated to be 30 g (range, 16-45 g) birthweight and 0.17 FM% (range, 0.04-0.29 FM%) per kg∙m–2 pBMI and 31 g (range, 18-44 g) and 0.24 FM% (range, 0.10-0.37 FM%) per kg GWG. The placental weight was the main mediator, mediating 25-g birthweight and 0.11 FM% per kg∙m–2 pBMI and 25-g birthweight and 0.13 FM% per kg GWG. The maternal mediators mediated a smaller part of the effect of pBMI (3.8-g birthweight and 0.023 FM% per kg∙m–2 pBMI) but not GWG.

Conclusion
Placental weight was the main mediator linking pBMI and GWG to birthweight and FM%. The effect of pBMI, but not GWG, on birthweight and FM%, was also mediated via the maternal and fetal mediators.
Effect of displacement on Adherence to TB Treatment: An observational study in TB patients from Internally Displaced Persons of Pakistan
Authors: Khan Farman Ullah , Asghar Zahid , Tipu Muhammad Khalid , Rehman Asim .ur. , Khan Asif , Rehman Tofeeq Ur- 
Published: March 2021

Objective: This study was aimed to investigate TB patients adherence and treatment outcomes among internally displaced patients in comparison with adjacent settled areas.
Methods: The study was designed as an observational cross-sectional study among the TB patients of internally displaced populations (IDPs) of North Waziristan Agency (NWA) and adjacent settled areas of Bannu and Lakki Marwat (NIDPs). Based on the study inclusion and exclusion criteria 330 patients fullfilled the inclusion criteria and were assigned equally to both IDPs and NIDPs study groups. Odds ratio (OR) with 95% confidence interval was calculated and p-values, 0.05 were considered statistically significant.
Results: The treatment outcomes with the status of “cured” and “completed treatment” were better among NIDPs as compared to IDPs. Patients with treatment outcome status of “defaulted treatment”, “without documentary evidence, and “failure” were high in IDPs as compared to NIDPs. Adherence to TB treatment was better among NIDPs (50.9%) as compared to IDPs (39.4%). The patients showing non-adherence to TB treatment were more among IDPS (27.3%) than NIDPs (10.9%).
Conclusion: Overall results of this study revealed a poor adherence to the TB treatment medications with an odds ratio of 0.286, (p<0.05) among IDPs as compared with NIDPs.
doi: https://doi.org/10.12669/pjms.37.3.2992
How to cite this:Khan FU, Asghar Z, Tipu MK, Asim.ur.Rehman, Khan A, Tofeeq Ur-Rehman. Effect of displacement on Adherence to TB Treatment: An observational study in TB patients from Internally Displaced Persons of Pakistan. Pak J Med Sci. 2021;37(3):675-679. doi: https://doi.org/10.12669/pjms.37.3.2992
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Screening of ZIKA virus infection among dengue-like illness patients with negative RT-PCR for dengue virus in Punjab–Pakistan
Authors: Iqtadar Somia , Vo Thuan Huu , Mehmood Mehreen , Salman Muhammad , Malik Mamunur Rahman , Masud Faisal , Minh Nhu Nguyen Tran 
Published: March 2021

Objective: To detect ZIKV using reverse transcription-polymerase chain reaction (RT-PCR) among clinical samples tested negative for Dengue virus (DENV) by RT-PCR in Punjab, 2016.
Methods: A descriptive cross-sectional study was carried out for duration of two months. Total of 506 samples were collected within seven days from onset of illness from all over hospitals of Punjab, Pakistan of which 350 were selected simply randomly to test for presence of ZIKV by using “Trioplex Real-Time RT-PCR Assay (Trioplex)”. Cohen’s kappa coefficient (κ) and 95% confidence interval (CI) were used to assess the degree of concordance between DENV positive results of non-structural protein 1 (NS1) and IgM solid-phase enzyme immunoassay (ELISA).
Results: No samples were positive for any ZIKV, DENV or Chikungunya virus (CHIKV) by Trioplex. Among the 350 samples, 26 samples were positive concordant and the degree of concordance between NS1- and IgM-ELISA was 13% and κ coefficient was -0.71 (95% CI -0.79, -0.63).
Conclusion: At study time, no samples were positive for ZIKV. Strengthening laboratory capacity to confirm arboviruses for Punjab’s laboratories is warranted. Trioplex RT-PCR has 100% sensitivity so there are nominal chances of false negative results. Establishing syndromic surveillance for Zika and conducting a sero-surveillance survey for Zika in areas with high human and Aedes mosquito density are recommended in Punjab.
List of Abbreviations: ZIKV: Zika virus, DENV: Dengue virus, CI: Confidence interval, NS1: Non-structural protein 1, HRP: Horseradish peroxidase, IQR: interquartile range, CHIKV: Chikungunya virus, YF: Yellow fever, JE: Japanese encephalitis, PoE: Points of entry.
doi: https://doi.org/10.12669/pjms.37.3.3369
How to cite this:Iqtadar S, Vo TH, Mehmood M, Salman M, Malik MR, Masud F, et al. Screening of ZIKA virus infection among dengue-like illness patients with negative RT-PCR for dengue virus in Punjab–Pakistan. Pak J Med Sci. 2021;37(3):721-726. doi: https://doi.org/10.12669/pjms.37.3.3369
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cutaneous T-cell lymphoma: practical recommendations to enhance clinical practice
Authors: Howles Allison , Scarisbrick Julia 
Published: March 2021

Management of cutaneous T-cell lymphoma should provide a holistic approach to a patient's wellbeing. Treatments depend on the stage of lymphoma. Patients with the early stages tend to have a near-normal life expectancy. Management should be aimed at improving the extent of disease and reducing symptoms with minimal therapeutic adverse effects. Skin-directed treatments are preferred and may be used in combination with treatments for symptom relief such as anti-pruritic medication. In advanced stages of disease where the median life expectancy is reduced the aims are also to prevent disease progression and prolong life, and this requires a multidisciplinary approach. Symptom control remains important as patients often have painful, itchy disfiguring lesions which greatly impact on health-related quality of life. National and international guidelines provide stage-related treatment options to be considered with first-line options followed by subsequent second-line therapies. All are listed in no particular order of preference and are chosen according to patients' needs and expertise of the treating centre. Several first-line options may be chosen before moving to the second-line options. Three drugs received European Medicines Agency approval in 2017 and 2018 (chlormethine gel, brentuximab and mogamulizumab) but there still remains an unmet need for more improved treatments or combinations. Most treatments only result in a partial response and there is no cure for early-stage disease; as such, patients live for a long time with their disease. In the advanced stages if a good response is achieved eligible patients will be considered for an allogeneic haematopoietic stem cell transplant.
A new measure to understand the role of science in US Congress: lessons learned from the Legislative Use of Research Survey (LURS)
Authors: Long Elizabeth C. , Smith Rebecca L. , Scott J.Taylor , Gay Brittany , Giray Cagla , Storace Rachel , Guillot-Wright Shannon , Crowley D. Max 
Published: March 2021

Background: There is growing interest in and recognition of the need to use scientific evidence to inform policymaking. However, many of the existing studies on the use of research evidence (URE) have been largely qualitative, and the majority of existing quantitative measures are underdeveloped or were tested in regional or context-dependent settings. We are unaware of any quantitative measures of URE with national policymakers in the US.
Aims and objectives: Explore how to measure URE quantitatively by validating a measure of congressional staff’s attitudes and behaviors regarding URE, the Legislative Use of Research Survey (LURS), and by discussing the lessons learned through administering the survey.
Methods: A 68-item survey was administered to 80 congressional staff to measure their reported research use, value of research, interactions with researchers, general information sources, and research information sources. Confirmatory factor analyses were conducted on each of these five scales. We then trimmed the number of items, based on a combination of poor factor loadings and theoretical rationale, and ran the analyses on the trimmed subscales.
Findings: We substantially improved our model fits for each scale over the original models and all items had acceptable factor loadings with our trimmed 35-item survey. We also describe the unique set of challenges and lessons learned from surveying congressional staff.
Discussion and conclusions: This work contributes to the transdisciplinary field of URE by offering a tool for studying the mechanisms that can bridge research and policy and shedding light into best practices for measuring URE with national policymakers in the US.
The role conflict of physical education and sport teachers in Turkey: Teaching or coaching?
Authors: Fakazlı Ahmet Emre , İlhan Ekrem Levent 
Published: March 2021

Physical education (PE) teachers in Turkey fulfill the coaching role within school sports activities in addition to teaching roles. However, coaching and teaching are different professional fields. In this regard, it is estimated that PE teachers experience role conflicts in the current system. The present study aimed to evaluate the role conflict situation from different perspectives in accordance with the opinions of the PE teachers. Six PE teachers, three female and three males, voluntarily participated in the study. In order to examine the role conflict in depth and to explain this situation better, the research was designed as phenomenology in qualitative research method A semi-structured interview form prepared by the researchers was used as a data collection tool. In the analysis of the data obtained, content analysis method was used to make objective and systematic inferences. The study yielded the outcome that especially young PE teachers had a role conflict and that they were negatively affected by this situation. PE teachers with a high level of sportive background stated that they felt closer to the coaching role than the teaching role. Finally, all PE teachers who participated in the study emphasized that coach support was very important in this process. They also reported that they could not spare time for their families and relatives due to high training hours and that they experienced physical and mental fatigue.

Özet
Türkiye’de beden eğitimi (BE) öğretmenleri öğretmenlik rollerinin yanında okul sporları faaliyetleri kapsamında antrenörlük rolünü de yerine getirmektedirler. Ancak antrenörlük ve öğretmenlik birbirinden farklı mesleki alanlardır. Bu kapsamda, BE öğretmenlerinin mevcut sistem içerisinde rol çatışması yaşadıkları öngörülmüştür. Bu araştırmada, rol çatışması durumunun Türkiye’deki BE öğretmenlerinin görüşleri doğrultusunda farklı açılardan değerlendirilmesi amaçlanmıştır. Araştırmaya üç kadın, üç erkek olmak üzere toplamda altı BE öğretmeni gönüllü olarak katılmıştır. Araştırma, rol çatışması durumunu derinlemesine incelemek ve bu durumu daha iyi açıklamak amacıyla nitel araştırma yönteminde fenomenoloji deseninde tasarlanmıştır. Veri toplama aracı olarak araştırmacılar tarafından hazırlanmış yarı yapılandırılmış görüşme formu kullanılmıştır. Elde edilen verilerin analizinde, objektif ve sistematik çıkarımlar yapmak amacıyla içerik analizi yöntemi kullanılmıştır. Araştırma sonucunda, özellikle genç BE öğretmenlerinin bu durumdan olumsuz etkilendikleri ve rol çatışması yaşadıkları sonucuna ulaşılmıştır. Üst düzey sportif geçmişe sahip BE öğretmenleri öğretmenlik rolüne kıyasla antrenörlük rolüne kendilerini daha yakın hissettiklerini belirtmişlerdir. Son olarak, araştırmaya katılan tüm BE öğretmenleri yüksek antrenman saatleri sebebiyle aile ve yakınlarına vakit ayıramadıkları, fiziksel ve zihinsel anlamda yorgunluk yaşadıklarını ifade ederek, antrenör desteğinin bu süreçte oldukça önemli olduğunu vurgulamışlardır.
Determinants of Innovativeness in Manufacturing Small and Medium Enterprises in Kenya
Authors: Mkalama Ben , Ndemo E. Bitange , Maalu Jackson , Pokhariyal Ganesh 
Published: March 2021

In spite of firm innovativeness being identified as essential for growth, there exists a dearth of studies that relate entrepreneurial orientation and innovativeness in manufacturing small and medium enterprises in the developing world. In this article, we unpack the dimensions of entrepreneurial orientation and examine their influence on innovativeness of manufacturing small and medium manufacturing enterprises. This was a cross sectional survey with a stratified sample size of 363 firms. Regression models were used to validate the derived hypothesis. We discuss the implications of the results which show that the dimensions were individually not found to have a significant effect on innovation but yet entrepreneurial orientation had an influence on firm innovativeness. We identify the need for additional studies to broaden the scope of future studies across several geographies. We conclude by challenging the ever-dynamic local institutional policies that have not had a significant impact on the effect of entrepreneurial orientation on innovativeness of SMEs across many developing countries.
THE LANGUAGE OF THE “LIVING LIGHT”: SEMIO-BIO-PHOTONICS, ANOTHER EMERGENT APPROACH
Authors: Stanciulescu Traian D. , Nilaya Shanti 
Published: March 2021

The intention of the present paper is to propose an original connection between semiotics and biophotonics, the unconventional discipline considered as the study of the “ultraweak delayed bioluminescence” emitted by all the living systems (Popp, 1989). The synergy of semiotics and biophotonics − able to assume scientifically the language of the “living light” − is representing the strategy already named by authors Semio-Bio-Photonics (SBPh: Stănciulescu, Nilaya, 2017). In order to define it, the paper is briefly describing and justifying the SBPh scenario of the consciousness and implicitly of (verbal) language genesis. So, the purpose of the present synthesis is to finally recognize that a SBPh integrative approach is indeed possible and necessary for understanding who the real homo significans and homo loquens is.
The dual cone of sums of non-negative circuit polynomials
Authors: Dressler Mareike , Naumann Helen , Theobald Thorsten 
Published: March 2021

Abstract
For a non-empty, finite subset

A

⊆

N

0
n

$\mathcal{A} \subseteq \mathbb{N}_0^n$

let C
sonc(𝒜) ∈ ℝ[x
1, . . . , xn
] be the cone of sums of non-negative circuit polynomials with support 𝒜. We derive a representation of the dual cone (C
sonc(𝒜))∗ and deduce an optimality criterion for sums of non-negative circuit polynomials in polynomial optimization.
On static manifolds and related critical spaces with cyclic parallel Ricci tensor
Authors: Baltazar H. , Da Silva A. 
Published: March 2021

Abstract
We classify 3-dimensional compact Riemannian manifolds (M
3, g) that admit a non-constant solution to the equation −Δfg +Hess f − f Ric = μ Ric +λg for some special constants (μ, λ), under the assumption that the manifold has cyclic parallel Ricci tensor. Namely, the structures that we study here are: positive static triples, critical metrics of the volume functional, and critical metrics of the total scalar curvature functional. We also classify n-dimensional critical metrics of the volume functional with non-positive scalar curvature and satisfying the cyclic parallel Ricci tensor condition.
Rational conic fibrations of sectional genus two
Authors: Lanteri Antonio , Mallavibarrena Raquel 
Published: March 2021

Abstract
Polarized rational surfaces (X, L) of sectional genus two ruled in conics are studied. When they are not minimal, they are described as the blow-up of 𝔽1 at some points lying on distinct fibers. Ampleness and very ampleness of L are studied in terms of their location. When L is very ample and there is a line contained in X and transverse to the fibers, the conic fibrations (X, L) are classified and a related property concerned with the inflectional locus is discussed.
Should Liability Insurance Be Compulsory for Bicycle Accidents?
Authors: Okura Mahito , Sakaki Motohiro , Yoshizawa Takuya 
Published: March 2021

Abstract
This study examines whether the introduction of compulsory bicycle liability insurance is socially desirable when evaluation bias—the difference between the objective and subjective evaluations of liability amounts—exists. The main results of this study are summarized as follows. First, when there is no evaluation bias, the introduction of compulsory bicycle liability insurance is socially desirable when the interest rate is high without any condition, and the loading rate is low, the maximum amount of liability is small, and the effort cost is high if the loading rate is higher than the interest rate. Second, if there is an evaluation bias and the accident probability is uniformly distributed, more severe additional conditions are needed for deriving the same results. The study concludes that the evaluation bias prevents the realization of the situation in which the introduction of compulsory bicycle liability insurance is socially desirable.
Biochemical assessment of metabolic associated fatty liver disease
Authors: Guerra-Ruiz Armando R. , Casals Gregori , Iruzubieta Paula , Lalana Marta , Leis Alba , López Rosa María , Crespo Javier , Morales-Ruiz Manuel 
Published: March 2021

Abstract
Metabolic-associated fatty liver disease (MAFLD) is defined as fat accumulation in the liver in the presence of metabolic alterations. This disorder is generally asymptomatic and may progress to severe liver disease, which are linked to inflammation and/or fibrosis. MAFLD has a high prevalence (26%) and therefore a considerable number of patients are at high risk of having advanced liver disease. This document provides an overview of the most relevant serological markers in the characterization and diagnosis of MAFLD. An example is provided of a routine diagnostic algorithm that incorporates serological testing. A range of useful serological scores are currently available for the management of MAFLD patients, especially for the stratification of patients at risk of fibrosis. A large proportion of the population is at risk of developing severe liver disease. The integration of non-invasive serological markers in the stratification of patients at risk for liver fibrosis may contribute to improve the control and management of MAFLD patients.