bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haemocytes are critical forDrosophila melanogasterpost-embryonic development, independent of control of the microbiota
Authors: Stephenson HN , Streeck R , Herzig A 
Published: October 2021

AbstractProven roles for haemocytes (blood cells) have expanded beyond the control of infections inDrosophila. Despite this, the critical role of haemocytes in post-embryonic development has long been thought to be limited to control of microorganisms during metamorphosis. This has previously been shown by rescue of adult development in haemocyte-ablation models under germ-free conditions. Here we show that haemocytes have a critical role in post-embryonic development beyond their ability to control the microbiota. Using a newly generated, strong haemocyte-specific driver line for the GAL4/UAS system, we show that specific ablation of haemocytes is pupal lethal, even under axenic conditions. Genetic rescue experiments prove that this is a haemocyte-specific phenomena. RNA-seq data suggests that dysregulation of the midgut is a critical consequence of haemocyte ablation. We believe this novel role of haemocytes during metamorphosis is a major finding for the field. This is an exciting newDrosophilamodel to study the precise mechanisms in which haemocytes regulate tissue development, findings from which could have far reaching implications beyond invertebrate biology.Summary StatementHaemocyte-ablation inDrosophila melanogasterwith a strong haemocyte-specific driver causes pupal lethality
Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries
Authors: Peuhu Emilia , Jacquemet Guillaume , Scheele Colinda LGJ , Isomursu Aleksi , Paatero Ilkka , Thol Kerstin , Georgiadou Maria , Guzmán Camilo , Koskinen Satu , Laiho Asta , Elo Laura L , Boström Pia , Hartiala Pauliina , van Rheenen Jacco , Ivaska Johanna 
Published: October 2021

AbstractDuctal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer, where the tumor is encapsulated by a basement membrane (BM). At the invasive phase, the BM barrier is compromised enabling tumor cells to escape into the surrounding stroma. The molecular mechanisms that establish and maintain an epithelial BM barrier in vivo are poorly understood. Myosin-X (MYO10) is a filopodia-inducing motor protein implicated in metastasis and poor clinical outcome in patients with invasive breast cancer (IBC). We compared MYO10 expression in patient-matched normal breast tissue and DCIS lesions and found elevated MYO10 expression in DCIS samples, suggesting that MYO10 might facilitate the transition from DCIS to IBC. Indeed, MYO10 promoted the formation of filopodia and cell invasion in vitro and positively regulated the dissemination of individual cancer cells from IBC lesions in vivo. However, MYO10-depleted DCIS xenografts were, unexpectedly, more invasive. In these xenografts, MYO10 depletion compromised BM formation around the lesions resulting in poorly defined tumor borders and increased cancer cell dispersal into the surrounding stroma. Moreover, MYO10-depleted tumors showed increased EMT-marker-positive cells, specifically at the tumor periphery. We also observed cancer spheroids undergoing rotational motion and recruiting BM components in a filopodia-dependent manner to generate a near-continuous extracellular matrix boundary. Taken together, our data identify a protective role for MYO10 in early-stage breast cancer, where MYO10-dependent tumor cell protrusions support BM assembly at the tumor-stroma interface to limit cancer progression, and a pro-invasive role that facilitates cancer cell dissemination at later stages.Abstract FigureHighlights-Filopodia sculpt the tumor-proximal stroma in pre-invasive ductal carcinoma in situ (DCIS).-Filopodia-dependent basement membrane (BM) assembly limits invasive transition of DCIS-like tumors in vivo.-Loss of MYO10-dependent filopodia impairs BM assembly and induces an EMT-like phenotype at the tumor-stroma interface in vivo.-MYO10 filopodia are anti-invasive in DCIS but facilitate dissemination in invasive breast cancer.
Analytical model of a T-core coil above a multi-layer conductor with hidden hole using the TREE method for nondestructive evaluation
Authors: Zhang Siquan 
Published: October 2021

Purpose
In eddy current nondestructive testing, a probe with a ferrite core such as an E-core coil is usually used to detect and locate defects such as cracks and corrosion in conductive material. However, the E-core coil has some disadvantages, such as large volume and difficulty in the process of winding the coils. This paper aims to present a novel T-core probe and its analytical model used for evaluating hidden holes in a multi- layer conductor.

Design/methodology/approach
By using a cylindrical coordinate system, the solution domain is truncated in the radial direction. The magnetic vector potential of each region excited by a filamentary coil is derived, and the expansion coefficients of the solutions are obtained by matching the boundary and interface conditions between the regions. By using the truncated region eigenfunction expansion method, the final expression in closed form for the impedance of the multi-turn coil is worked out, and the impedance calculation is performed in Mathematica. For frequencies ranging from 100 Hz to 100 kHz, both the impedance changes of the T-core coil above the multi-layer conductor without a hidden hole and in the absence of the layered conductor were calculated, and the influence of a hidden hole in the multi-layer conducting structure on the impedance change was investigated.

Findings
The correctness of the analytical model of the T-core coil was verified by the finite element method and experiments. The proposed T-core coil has higher sensitivity than an air-core coil, and similar sensitivity and smaller size than an E-core coil.

Originality/value
A new T-core coil probe and its accurate theoretical model for defect evaluation of conductor were presented; probe and analytical model can be used in probe design, detection process simulation or can be directly used in defect evaluation of multi-layer conductor.
Productivity story of Iranian librarians: assessing the impact of knowledge management and emotional intelligence
Authors: Sarhadi Zahra , Kaffashan Kakhki Mojtaba , Behzadi Hassan 
Published: October 2021

PurposeThis study aims to assess the effect of knowledge management (KM) development and emotional intelligence (EI) on the productivity of librarians regarding the mediating role of job motivation (JM) and job feedback (JF).Design/methodology/approachThis study was carried out in two phases. First, the variables affecting the productivity of librarians were identified and selected through an explorative study and by surveying their opinions. Then, the theoretically designed model was administered to 312 librarians at Iranian public libraries. A questionnaire was used to collect data, and the structural equation modelling technique was used to analyse data.FindingsThe results of this study showed that KM and EI, mediated by JM and JF, had a positive and significant effect on developing the librarians’ productivity. The results also revealed that JF had a positive effect on JM and that JF was more effective on productivity than JM. This study marginally proved the direct effect of KM and EI on productivity where KM was more effective than EI on productivity. Knowing the effects of organizational and individual factors on the higher productivity of librarians in public libraries will help library managers make more efficient use of those factors in developing the capabilities of librarians and enhancing productivity.Originality/valueThis study is one of the few studies of its kind that facilitates the perception of the concept of productivity in public libraries and also the assessment of the effects of organizational and individual factors on the librarians’ productivity.
Career satisfaction antecedents of professional accounting returnees in international workplaces: an employee experience perspective
Authors: Ho Nga Thi Thuy , Hoang Hung Trong , Seet Pi-Shen , Jones Janice , Pham Nhat Tan 
Published: October 2021

PurposeThe purpose of this study is to examine the determinants of career satisfaction of professional accounting returnees who have studied and/or worked abroad and then returned to work in different types of international workplaces in their home country.Design/methodology/approachA survey of professional accounting returnees in Vietnam was undertaken and multiple regression analysis was applied to test the proposed relationships.FindingsThis study finds that career satisfaction is affected by career fit, career sacrifice, types of international workplaces (domestically headquartered firms versus globally headquartered firms) and cross-cultural work readjustment. Further, cross-cultural work readjustment partially mediates the effect of career fit and career sacrifice on career satisfaction.Practical implicationsThe research provides the basis for designing career-related employee experiences to support career satisfaction of professional accounting returnees.Originality/valueThis study integrates dimensions of career embeddedness with cross-cultural work readjustment and employee experiences, which are normally studied separately, in different types of international workplaces. It contributes to the limited research on contributors to well-being in the form of career satisfaction among professional returnees in an emerging economy.
Investment environment, stock market perception and stock investments after stock market crash
Authors: Khan Mohammad Tariqul Islam , Tan Siow-Hooi , Chong Lee-Lee , Goh Gerald Guan Gan 
Published: October 2021

PurposeThis study examines how the importance of external investment environment factors affects stock market perception, and how stock market perception affects stock investments after stock market crash witnessed by individual investors in one of the emerging stock markets.Design/methodology/approachA cross-sectional survey was administrated among 223 individual investors who experienced stock market crash in 2010–2011 in Bangladesh, and the proposed model was tested by the partial least squares-structural equation modeling PLS-SEM model.FindingsFindings show that the importance of Bangladesh's stock market performance, government policy, economic issues and neighboring country's stock market performance have effects on investors' stock market perception. This perception, in turn, decreases monthly stock trading and short-term investment horizon. The findings further show the mediating effect of stock market perception.Practical implicationsInvestors need to carefully consider the external investment environment when they form their stock market perception, as this perception drives stock investments. Analogously, regulators should ensure releasing timely and updated statistics on external investment factors.Originality/valueAddressing those investors who encountered stock market crash, a set of external investment environment issues, stock market perception and stock investments are new in the literature.
Financial determinants of value based performance of construction firms in India
Authors: Singla Harish Kumar , Prakash Anand 
Published: October 2021

PurposeThe purpose of the study is to examine the value-based performance of firms in construction sector in India using Tobin's Q and Market Capitalization (MCAP) and then determine their significant financial drivers.Design/methodology/approachThe study is based on data from 87 firms engaged in infrastructure, real estate, industrial construction and allied areas in India over a study period of 10 years. Three distinct forms of panel regression models have been developed using Tobin's Q and MCAP as dependent variables. The models developed are using Baltagi's (1981) Error Component 2SLS, Varadharajan-Krishnakumar's (1987) Generalized 2SLS and Arellano – Bower/Blundell – Bond's (1991) dynamic panel.FindingsThe study found that MCAP is a better suited value-based performance measure for construction sector firms in India. The study further reports that the age of the firm, profit after tax, investment in research and development, dividends, leverage and net fixed asset are significant positive drivers, whereas cash flow is a significant negative driver.Research limitations/implicationsThe study is limited to a geographic location; therefore, the findings of this study cannot be generalized.Practical implicationsAs MCAP is a better suited value-based performance measure of a firm in the construction sector, managers should focus on improving profitability, higher research and development activities, higher dividends and higher expenditures on net fixed assets for improvement.Originality/valueThis is an original attempt to examine the value-based performance of firms in the construction sector in India using Tobin's Q and MCAP.
Exploring trust: culturally responsive and positive school leadership
Authors: Banwo Bodunrin O. , Khalifa Muhammad , Seashore Louis Karen 
Published: October 2021

PurposeThis article explores the connection between Culturally Responsive School Leadership (CRSL) and Positive School Leadership (PSL) and how both engage with a concept that deeply connects both leadership expressions – trust.Design/methodology/approachA multi-year, single site case study method examined a district-level equity leader, and her struggles and successes with promoting equity and positive culture throughout a large suburban district in the US.FindingsTrust, established through regular interactions, allowed the district's leadership equity team to build positive relationships with building leaders. Trust was not only a mitigating factor on the relationships themselves, but also regulated the extent to which equitable practices were discussed and implemented in the district. Trust allowed conflicts to surface and be addressed that led to individual and organizational change.Research limitations/implicationsThe case highlights the importance of both CRSL and PSL principals, along with the idea of “soft power” in cultural change, to foster equity in schools. Established trust does not erase the difficulties of enacting CRSL/PSL, but allows the difficulties to be addressed. The authors found that dynamic, iterative, regular interactions over a long period reinforced trust allowed CRPSL to take root in the district.Originality/valueThe authors use a single subject case to argue that the core of empirical work moving forward should draw on an integration of culturally responsive leadership.
Protein quality assessment of pecan [Carya illinoinensis (wangenh.) K. Koch] and pine (Pinus gerardiana wall.) nuts for dietary supplementation
Authors: Tanwar Beenu , Modgil Rajni , Goyal Ankit 
Published: October 2021

Purpose
The purpose of this study is to assess the protein (biological) quality of pecan and pine nuts supplemented diets in male Wistar albino rats.

Design/methodology/approach
A randomized and controlled study (45 d) was conducted in male Wistar albino rats (n = 60) comprising six groups, namely, control (Cc), control with 1% cholesterol (CC1), Pecan group (Pe), Pecan group supplemented with 1% cholesterol (Pi1), Pine group supplemented with 1% cholesterol (Pi1). Protein quality of supplemented diet/s was assessed in terms of various biological indices.

Findings
Pe and Pi groups exhibited normal growth when compared with Cc. Despite showing higher feed and protein intake, Pe and Pi groups exhibited significantly (P = 0.023) lower weight gain than Cc. There was no significant difference between the protein efficiency ratio (3.8 ± 0.2 and 3.7 ± 0.2), apparent protein digestibility (81.5 ± 2.2 and 80.5 ± 2%), true protein digestibility (90.6 ± 1.1 and 88.5 ± 3.5%) and biological value (BV) (75.6 ± 0.9 and 72.6 ± 0.9%) of Pe and Pi groups, respectively. Pe group presented considerably higher net protein utilization (68.5 ± 1.4 vs 64.4 ± 0.8%) and protein retention efficiency (34.8 ± 1.1 vs 31.2 ± 1.3%) than Pi group. Overall, pecan-based diet displayed superior biological quality over pine nut. Antinutrients present in the nuts did not show any major negative effect on the growth, digestibility and bioavailability of the nutrients in rats. BV ranging from 72.6% to 75.6% suggested a satisfactory quality of experimental nut-based diets.

Research limitations/implications
Further investigation of pecan and pine nuts consumption to examine the potential benefits and associated mechanisms of action is warranted which would aid in a better understanding and to establish nutritional recommendations.

Originality/value
Overall, the exploitation of pecan and pine nut flours for the development of value-added food products is favorable from a nutritional point of view.
Does fiscal pressure constrain policy responsiveness? Evidence from Germany
Authors: ELSÄSSER LEA , HAFFERT LUKAS 
Published: October 2021

AbstractPolitical responsiveness is highly unequal along class lines, which has triggered a lively debate about potential causes of this political inequality. What has remained largely unexplored in this debate are the structural economic conditions under which policymakers operate. In this contribution, we hypothesize that budgetary pressures affect both the level and the equality of political responsiveness. Using a dataset containing public opinion data on around 450 fiscal policy proposals in Germany between 1980 and 2016, we investigate whether policymakers are more responsive on issues with budgetary consequences under conditions of low fiscal pressure than under conditions of high fiscal pressure. We find that responsiveness indeed varies systematically with the degree of fiscal pressure and that policymakers are less responsive on fiscal issues when fiscal pressure is high. This holds for both left‐wing and right‐wing governments. In contrast, we do not find strong effects of fiscal pressure on political inequality: responsiveness is not more equal in fiscally more permissive times. However, since different types of policy proposals are adopted in times of high fiscal stress, unequal responsiveness has different policy implications in times of high and low fiscal pressure.
Pathways from maternal depressive symptoms to children’s academic performance in adolescence: A 13‐year prospective‐longitudinal study
Authors: Bechtiger Laura , Steinhoff Annekatrin , Dollar Jessica M. , Halliday Simone E. , Keane Susan P. , Calkins Susan D. , Shanahan Lilly 
Published: October 2021

AbstractThe pathways through which exposure to maternal depressive symptoms in early childhood are linked to academic performance during adolescence are poorly understood. This study tested pathways from maternal depressive symptoms (age 2–5) to adolescent academic performance (age 15) through cumulative parenting risk (age 7) and subsequent child functioning (age 10), using multi‐informant data from a prospective longitudinal community study spanning 13 years (N = 389, 47% male, 68% White). Structural equation models testing indirect effects revealed small associations between maternal depressive symptoms and increased cumulative parenting risk and poorer child functioning, and, via these pathways, with poorer academic performance. Thus, childhood exposure to maternal depressive symptoms may be associated with pathways of risk that could limit children's educational opportunities.
Potential new therapeutic target for Alzheimer's disease: Glucagon‐like peptide‐1
Authors: Liu Xiao‐Yu , Zhang Ni , Zhang Sheng‐Xiao , Xu Ping 
Published: October 2021

AbstractIncreasing evidence shows a close relationship between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM). Recently, glucagon‐like peptide‐1 (GLP‐1), a gut incretin hormone, has become a well‐established treatment for T2DM and is likely to be involved in treating cognitive impairment. In this mini review, the similarities between AD and T2DM are summarised with the main focus on GLP‐1‐based therapeutics in AD.
Bacterial membrane vesicles shape Staphylococcus aureus skin colonization and induction of innate immune responses
Authors: Staudenmaier Lena , Focken Jule , Schlatterer Katja , Kretschmer Dorothee , Schittek Birgit 
Published: October 2021

AbstractStaphylococcus aureus colonization is abundant on the skin of atopic dermatitis (AD) patients where it contributes to skin inflammation. S. aureus produces virulence factors that distinguish it from commensal skin bacteria such as S. epidermidis and S. lugdunensis. However, it has remained unclear, which of these virulence factors have the strongest impact on AD. Membrane vesicles (MVs) are released by pathogenic bacteria and might play an essential role in the long‐distance delivery of bacterial effectors such as virulence factors. We show that MVs are also released by skin commensals in a similar quantity and membrane lipid amount as those from pathogenic S. aureus. Interestingly, MVs from skin commensals can protect against S. aureus skin colonization by conditioning human skin for enhanced defence. In contrast, MVs released by S. aureus are able to induce CXCL8 and TNF‐α in primary human keratinocytes, recruit neutrophils and induce neutrophil extracellular traps, which enhance S. aureus skin colonization. CXCL8 induction is TLR2‐ and NFkB‐dependent and the induction level correlates with the membrane lipid and protein A content of the MVs. Interestingly, MVs of S. aureus strains from the lesional skin of AD patients show an enhanced membrane lipid and protein A content compared to the strains from the non‐lesional sites and have an enhanced proinflammatory potential. Our data underline the complex interplay in host‐ and bacterial derived factors in S. aureus skin colonization and the important role of bacterial derived MVs and their membrane lipid and protein A content in skin inflammatory disorders.
Methodological shortcomings in the reports of the imiquimod psoriatic model
Authors: Vinardell M. Pilar 
Published: October 2021

AbstractPsoriasis is a chronic inflammatory skin disease affecting about 2–3% of the worldwide population. More of the knowledge of psoriasis is due to the in vitro and in vivo models tried to reproduce the disease and to know the mechanisms of pathogenesis, as well as to develop new therapies. One of the more simple, cheap and more used models is the imiquimod model based on the application of imiquimod in the depilated skin of mice. Several studies describing the methodology employed to develop an animal disease model does not present all the details about the model more especially related to the use of one sex or another and other methodological aspects that are relevant for researchers and to consider the accuracy of the study. In this review, we have selected 100 papers published in the last five years using the imiquimod psoriatic model recording different data such as animal, strain, sex, dose of imiquimod, area of administration, housing information, anaesthesia/euthanasia information, number of animals per group and control details among others. Our results revealed several methodological shortcomings in the models of imiquimod to study psoriasis namely sex bias and discrepancies in dose applied or time of imiquimod application among others. As long as these discrepancies exist in animal methodologies, there will be a poor translation from animal studies to clinical applications in dermatology and in other areas.