bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Job Shop Scheduling Problem Using Genetic Algorithm and Simulated Annealing: A Case Study of Manufacturing Industry
Authors: Gupta Shrajal , Phanden Rakesh Kumar , Wolde Biruk , Kumar Ravinder , Chakraborty Ayon 
Published: December 2024

Abstract

Production scheduling is an important activity within the manufacturing system to improve its performance. It is a process of assigning resources to the task or vice versa, which depends upon the configuration of the shop floor and the type of products to be manufactured. In job shops, scheduling is a very complex task since it involves a variety of products to process on a limited number of machines to cut down on the amount of time it takes to do tasks. In the present work, a case study from the manufacturing industry has been taken to maximise the amount of time it takes to do tasks (i.e.,makespan) having job shop configuration. Two distinguished nature-inspired algorithms, viz Simulated Annealing (SA) and Genetic Algorithm (GA), have been pragmatic in optimising the existing schedule. The results show that GA outperform the SA by a 1.76% increment in the makespan value. Also, the GA and SA possessed better results than the company's existing production schedule by 32.23% and 31.02%, respectively.
Evaluation of Eclipta alba L. selections for higher biomass and bioactive compound
Authors: K Hima Bindu , V Keshav Rao , kumar Shiva , B Anil Kumar , M Shalini R , Sonavane Priti , S Divya K , S Sujatha 
Published: December 2024

Abstract

Known by several names, including Bhringaraj and False Daisy, Eclipta alba (L.) is a highly valued and well-known medicinal plant in India. It is thought to be the best liver disease medicine and is an annual herb that belongs to the Asteraceae family. This herb has a long history of use in ethnomedicine. An estimated 2000–5000 tons are traded annually. On the other hand, overexploitation of this species' wild populations is the result of strong domestic demand. In order to cultivate E. alba and lessen the strain on the wild population, the current study aims to identify elite germplasm from several places in India through an analysis of growth, yield, and content variation of primary active constituents. HPLC (High-Performance Liquid Chromatography) was used to analyze the wedelolactone content of 142 wild accessions of E. alba. Six lines of analysis showed a significant variance in wedelolactone throughout the entire plant, ranging from 0.09 to 0.53% on a dry weight basis. These lines were evaluated for two years for growth, yield, and active principle content. One elite accession (IIHR Sel EA 43) with 0.5% of the wedelolactone was identified with higher growth and yield attributes. This line is found to be suitable for large-scale commercial cultivation of E. alba.
Quantitative assessment of omega-3 and omega-6 polyunsaturated fatty acid fluxes between aquatic and terrestrial ecosystems of a small shaded river
Authors: Makhutova Olesia N. , Mashonskaya Yulia O. , Borisova Elena V. , Kislitsina Nadezhda I. , Shulepina Svetlana P. 
Published: December 2024

Abstract

Boreal forests are rich in small rivers, whose primary productivity is limited by shading. The diet of benthivorous fish in such rivers is based on autochthonous and allochthonous organic matter. Aquatic algae and invertebrates produce and accumulate polyunsaturated fatty acids of n-3 family (n-3 PUFA). Terrestrial organisms are poor in these substances but are rich in n-6 PUFA. We aimed to assess fluxes of biomass and n-3 and n-6 PUFA between aquatic and terrestrial ecosystems of the shaded Krutaya Kacha River. The production of zoobenthos in the river was 11.7 mg of dry weight (DW)·m− 2·day− 1, while the export of biomass of amphibious insects was 4.3 mg (DW)·m− 2·day− 1. The import of invertebrate biomass into the river was 56.2 mg (DW)·m− 2·day− 1, which was one order of magnitude higher than the export of amphibious insects and 5 times higher than the production of zoobenthos. The import of n-3 PUFA, and n-6 PUFA into the river via invertebrates was 0.55 and 0.909 mg (DW)·m− 2·day− 1, respectively, while the export of these substances from the river with emergent insects was lower by factors of 6.6 and 20.7, respectively. Thus, in such rivers, benthivorous fish feeding on aquatic and terrestrial resources receive food of biochemically different quality: the amounts of food being equal, fish consuming terrestrial invertebrates receive less n-3 PUFA but more n-6 PUFA than fish consuming aquatic invertebrates. The predominance of allochthonous food in the diet of fish can be the reason for the decrease in the nutritional value of fish inhabiting small shaded rivers.
Understanding the Transfer and Persistence of Antimicrobial Resistance in Aquaculture using a Model Teleost Gut System
Authors: Barcan Alexandru Stefan , Humble Joseph , Kasaragod Sandeep , Sajib Mohammad Saiful Islam , Barcan Rares Andrei , McGinnity Philip , Welch Timothy J. , Robertson Brenda , Vamanu Emanuel , Bagicalupo Antonella , Llewellyn Martin , Samsing Francisca 
Published: December 2024

Abstract

Background: The development, progression, and dissemination of antimicrobial resistance (AMR) are determined by interlinked human, animal, and environmental drivers, which pose severe risks to human and livestock health. Conjugative plasmid transfer drives the rapid dissemination of AMR among bacteria. In addition to the judicious use and implementation of stewardship programs, mitigating the spread of antibiotic resistance requires an understanding of the dynamics of AMR transfer among microbial communities, as well as the role of various microbial taxa as potential reservoirs that promote long-term AMR persistence. Here, we employed Hi-C, a high-throughput, culture-free technique, combined with qPCR, to monitor carriage and transfer of a multidrug-resistent (MDR) plasmid within an Atlantic salmon in vitrogut model during florfenicol treatment, a benzenesulfonyl antibiotic widely deployed in fin-fish aquaculture.
Results: Microbial communities from the pyloric ceaca of three healthy adult farmed salmon were inoculated into three bioreactors simulating the teleost gut, which were developed for the SalmoSim gut system. The model system was then inoculated with the Escherichia coli strain ATCC 25922 carrying the plasmid pM07-1 and treated with florfenicol at a concentration of 150 mg/L in fish feed media for five days prior to the washout/recovery phase. Hi-C and metagenomic sequencing identified numerous transfer events, including those involving gram-negative and gram-positive taxa, and, crucially, the transfer and persistence of the plasmid continued once florfenicol treatment was withdrawn.
Conclusions: Our findings highlight the role of the commensal teleost gut flora as a reservoir for AMR even once antimicrobial selective pressure has been withdrawn. Our system also provides a model to study how different treatment regimens and interventions may be deployed to mitigate AMR persistence.
Impact of teacher feedback on the self-regulated learning of medical students: a chain mediating model of teacher-student interaction and sense of school belonging
Authors: Tian Jing , Hui Zhidan , Lei Hongde 
Published: December 2024

Abstract

Background Self-regulated learning is crucial for medical students’ lifelong learning and professional development. Research has found that self-regulated learning of medical students is influenced by teacher feedback. However, the mechanism by which teacher feedback affects the self-regulated learningof medical students has not yet been thoroughly explored.
Methods The study utilized data from five rounds of the Student Survey of Learning and Development Survey at H University in China, with a sample of 6,546 medical students selected. SPSS 26.0 and AMOS 26.0 were employed as data analysis tools to validate the relationships among variables such as teacher feedback, self-regulated learning, teacher-student interaction, and sense of school belonging.
Results Teacher feedback was significantly and positively correlated with self-regulated learning (r = 0.330, p < 0.01), teacher-student interaction (r = 0.311, p < 0.01), and sense of school belonging (r = 0.409, p < 0.01). Moreover, teacher-student interaction and sense of school belonging partially mediated the relationship between teacher feedback and self-regulated learning, with effect sizes of 0.116 and 0.045, respectively. There was a chain mediation model between teacher feedback and self-regulated learning that had a value of 0.009, accounting for 2.94% of the total impact.
Conclusion The research has unveiled the relationship between teacher feedback and the self-regulated learning of medical students, confirming the individual and chained mediating effects of teacher-student interaction and sense of school belonging. Furthermore, the current findings offer fresh perspectives for exploring effective approaches to improve medical students’ self-regulated learning.
Microbial Biomass Carbon Distribution under Agroforestry Practices and Soil Depth Variations in Southern Ethiopia
Authors: Masebo Nebiyou , Birhane Emiru , Takele Serekebrehane , Lucena Juan J. , Pérez-Sanz Araceli , Yunta Felipe , Belay Zerihun , Anjulo Agena 
Published: December 2024

Abstract

The land-use change from agroforestry (AF) to monoculture-based agriculture has the potential to change soil microbial biomass carbon (MBC). The MBC has been used as an indicator of soil quality as well as to determine the microbial status of soil. The aim of this study was to analyze the distribution of soil MBC across different agroforestry practices (AFPs) at two depths in southern Ethiopia. Soil samples were collected from cropland/parkland, woodlots, home gardens, and trees on soil and water conservation-based AFPs. The MBC was determined using the difference in fumigated and non-fumigated extracted carbon contents. The MBC and soil microbial biomass quotient (MBQ) were significantly different among the different AFPs (P < 0.05). The highest contents of MBC were reported from homegarden on topsoil (505.36 ± 12.45 mg kg − 1) and subsoil (401.88 ± 7.26 mg kg − 1) soil depths (surface = 0–30 cm, subsoil = 30–60 cm), followed by woodlot (surface: 464.37 ± 9.19 mg kg − 1) and (subsoil: 380.24 ± 6.88 mg kg − 1), while the lowest result was registered from the subsoil of the croplands (153.10 ± 46.44 mg kg − 1). The higher percentage of MBQ was recorded under the woodlots in topsoil layers (1.48%) and subsoil (1.37%), followed by homegarden (surface = 1.41%, subsoil = 1.25%), while the lowest was found under the cropland in subsoil (0.57%). The highest content of soil organic carbon was found under homegarden in topsoil (3.62%) and subsoil (3.23%) followed by woodlot (topsoil: 3.16%, subsoil: 2.87%) and trees on soil and water conservation structures (topsoil: 2.69%, subsoil: 2.51%), while the lowest value was registered under cropland/parkland AF practices (topsoil: 2.67%, subsoil: 2.46%). The distribution of MBC was significantly related to soil organic carbon in soil depth categories, soil total nitrogen, and soil pH in topsoil. Homegarden and woodlot AFPs were suitable for soil MBC improvement among the different AFPs studied, implying that tree-based systems are important for increasing of MBC and ecosystem stability.
Novel Carbon Material with Potential Application in Lead-Acid Battery Technology
Authors: Baraniak Marek , Płowens Radosław , Lota Katarzyna , Bajsert Marek , Lota Grzegorz 
Published: December 2024

Abstract

Lead-acid batteries (LABs) are one of the most important energy storage systems, widely used in automotive, industrial, and backup applications. However, lead-acid batteries exhibit limitations such as relatively low energy density, limited service life, etc. The aim of improving the performance of LABs is to search for new materials with better physicochemical and electrochemical properties. One of the most important research directions is the use of various types of carbon materials as additives to electrode active masses. The presented research involved the results of the effect of the addition of a new type carbon material on the properties of the positive and negative active masses of a lead-acid battery. The carbon material was obtained by carbonization of sheep's wool fibres. Experimental results show that the new additive improves the properties of active masses, especially during its preparation, although electrical conductivity of the carbon material is relatively low. This demonstrates that even carbon materials with moderate electrical properties can improve the efficiency of lead-acid battery production technology and its performance.
Objective and High-Precision Fabric Wrinkle Assessment using 3D Point Cloud Data and Deep Learning Techniques
Authors: Yuan Zhijie , Shen Zijun , Newton Md All Amin , Xin Binjie , Zhang Jing 
Published: December 2024

Abstract

This study presents a novel, high-precision method for objectively assessing fabric wrinkles utilizing 3D point cloud data and advanced deep learning techniques. Employing the EinScan-SP scanner, we generated a comprehensive dataset comprising 44 samples from 12 distinct fabric types. The intricate surface topologies of these fabrics were analyzed using PointNet, PointNet++, and PointNet++_MSG architectures, demonstrating their sensitivity to subtle wrinkle details. Our non-contact, automated approach significantly improves upon traditional wrinkle assessment techniques, offering an accurate and reliable means of quality control in the textile industry. The methodology's effectiveness was validated through comparative analysis, showcasing its superiority in terms of accuracy and repeatability. This study establishes a new benchmark for the precise evaluation of fabric surface characteristics, facilitating advancements in textile quality standards. The code and datasets are publicly available at https://github.com/YuanZhijie/FabricPointNet.
Ontogeny of adenohypophyseal cells, pituitary gland development, and structure in adults of Astyanax lacustris (Teleostei, Characidae): an emerging Neotropical model fish species
Authors: Branco Giovana Souza , Cassel Mônica , Chehade Chayrra , Camargo Marília Paiva , Dias Gisele C. Melo , Borella Maria Ines , de Jesus Lázaro Wender Oliveira 
Published: December 2024

Abstract

Pituitary gland morphogenesis and the ontogeny of the adenohypophyseal (AH) cells of Astyanax lacustris are presented herein. This Characiformes species shows great ecological and commercial importance, and it has been increasingly used as a biological model. The first AH cells of A. lacustris were detected at 1 dah by the immunostaining of prolactin (PRL) producing cells. The morphology of the gland presented changes in shape throughout the development, starting elongated but more oval at the end. The neurohypophysis was differentiated at 3 dah, along with the identification of adrenocorticotropic hormone (ACTH), melanotropic hormone (MSH), thyroid-stimulating hormone (TSH), and follicle-stimulating hormone (FSH) producing cells. Identification of the immunoreactive cells to anti-luteinizing hormone (LH), anti-somatolactin (SL), and anti-growth hormone (GH) antibodies occurred at 5 dah. At 20 dah, an increase in pituitary size and the presence of the pituitary stalk were observed. At 60 dah, the pituitary already had the same shape and distribution of AH cells seen in the adult. The ontogeny of adenohypophyseal cells in A. lacustris corroborates the heterogeneity in the appearance of these cell types in teleosts and suggests that these hormones actively participate during the post-hatching development of this species, even before the establishment of all endocrine axes. Our findings contribute to understanding the morphogenesis of the hypothalamic-pituitary axis in South American teleosts, providing essential data for the development of future studies related to pituitary gland morphophysiology under normal or experimental conditions.
Investigation of Castor-oil Foam Adhesion on Aluminium Through Single-lap Tests
Authors: Nogueira Luís Felipe Cabral Diogo , Santos Júlio Cesar dos , Panzera Túlio Hallak , Santos André Luís dos , Freire Rodrigo Teixeira Santos 
Published: December 2024

Abstract

This work investigates the adhesion of a castor-oil-based polyurethane (PU) biofoam to the surface of 1200 aluminium. The foam is fabricated using water as the blowing agent. The apparent shear strength, joint toughness and adherent strength of single-lap joints are assessed following the ASTM standard D1002. 3D-printed moulds are developed for sample preparation. The study evaluates three different bonding strategies related to polymer curing: (1) Simple Cure, (2) Co-Cure with Adhesive Layer and (3) Direct Bonding. The Simple Curing method is conducted by expanding the PU biofoam in the mould cavity in contact with the aluminium sheets. In the second method, a layer of castor-oil PU resin is previously applied to the internal aluminium surfaces before pouring the water-PU foaming mixture. The foaming process thus occurs inside the mould as in (2), with the additional co-cure of the adhesive PU resin layer on the aluminium sheets. In the direct bonding method (3), a slab of previously cured foam is bonded to the aluminium faces using a layer of castor-oil PU resin previously applied to the internal metallic surfaces, as in (2). This study is motivated by a subsequent study on foam-core sandwich panels, in which the best face-core bonding strategy will be used.
Development of an environmentally benign and stability-indicating assay and related substances RP-HPLC method and quantification of metronidazole in pharmaceutical formulations
Authors: Kulkarni Mrunalini , More Pranay 
Published: December 2024

Abstract

An antibiotic drug used to treat various bacterial infections such as skin, stomach, liver, joints, brain, vagina, spinal cord, lungs, heart or bloodstream. Different formulations like tablets, capsules, injections, creams, and ointments are available as commercial products. A concise, accurate, and reliable isocratic reverse-phase high-performance liquid chromatographic (RP-HPLC) method was designed to determine metronidazole drug substance in finished dosage forms quantitatively. This route ensures a shorter run time for elution while attaining consistent retention time for accurate results. This study developed a greener approach using Isopropyl alcohol (IPA) as a solvent.
This study employs a simple, specific, linear, accurate, and precise reverse-phase liquid chromatographic method to quantify Metronidazole's main component and assess the metronidazole-related process and degradation impurities in finished drug formulation. The Chromatographic separation was accomplished using a Water Symmetry C18 column with 100 mm x 4.6 mm dimensions and a particle size of 3.5 μm. The mobile phase, consisting of Isopropyl alcohol and water (20:80 v/v), was employed at a 1.000 ml/min flow rate with an injection volume of 10 μl. The column oven temperature was set at 30 °C, while the autosampler temperature was maintained at 25 °C. Wavelength detection was configured at 315 nm, resulting in a retention time of approximately 2.4 min for metronidazole.
Similarly, to quantify the organic impurities, the same chromatographic conditions were used in the related substances method except for altering the column using the Zorbax, SB, C8 with dimensions of 150 mm x 4.6 mm and a particle size of 3.5 μm.
In this report greener approach was implemented to develop a promising method that will reduce the difficulties associated with other reported methods similar to tedious in use, less sensitive, costly, etc. As the run time of the method is reduced, the solvent requirement is also reduced making the method greener. Further, this method was employed to assess the force degradation of metronidazole FPs. which demonstrated metronidazole Impurity-A and unspecified impurities were accurately quantified under several ICH-recommended stress conditions like hydrolytic, oxidation, and thermal.
Unlocking the Therapeutic Potential of 1,25(OH)₂D₃: Targeting Ferroptosis to Alleviate Lumbar Intervertebral Disc Degeneration
Authors: Li Qiang , Peng Jing , Ding Fan 
Published: December 2024

Abstract

Lumbar intervertebral disc degeneration (LIDD) is a primary cause of low back pain, a condition with significant global health and socioeconomic impacts. Recent studies have highlighted the role of ferroptosis, an iron-dependent form of programmed cell death, in nucleus pulposus (NP) cells degeneration. This study investigates the protective effects of 1,25(OH)₂D₃, the active form of Vitamin D, on LIDD by targeting ferroptosis. Our findings demonstrate that 1,25(OH)₂D₃ effectively suppresses ferroptosis in nucleus pulposus cells by reducing lipid peroxidation, restoring glutathione levels, and enhancing antioxidant defenses. Mechanistically, 1,25(OH)₂D₃ exerts its effects through activation of the Vitamin D receptor (VDR) signaling pathway, which regulates key ferroptosis-associated molecules such as GPX4 and SLC7A11. These results reveal the therapeutic potential of 1,25(OH)₂D₃ in mitigating LIDD, offering a novel approach to suppress ferroptosis and preserve intervertebral disc function.
A Pineal Region Meningioma Presenting with Acute Subarachnoid Hemorrhage: A Case Report and Literature Review
Authors: Alborihi Soliman Noman Abdullah , shamsaddeen Soliman , Nasher Abdulgany , Al-Kharazi Khalid , Alborihi Edress Noman Abdullah 
Published: December 2024

Abstract

Background and Importance:
The primary aim of this study is to present a rare case of a pineal meningioma that presented with subarachnoid hemorrhage.
Case Presentation:
A 54-year-old male patient presented with a headache but no other neurological symptoms. He had experienced a sudden severe headache, memory impairment, loss of consciousness, and vomiting 13 days prior, leading to his admission to the ICU where he was diagnosed with subarachnoid hemorrhage. Upon arrival at the Pioneer Doctors Center, the patient exhibited slightly elevated blood pressure but showed no significant neurological deficits. He was cooperative, conscious, and oriented, scoring 15/15 on the Glasgow Coma Scale. His medical history included occasional headaches over the past six months. Imaging studies, including brain CT angiography and MRI, revealed a well-defined mass in the pineal region, compressing nearby structures. The patient underwent a right occipital interhemispheric transtentorial approach for tumor resection. Post-surgery, he experienced blurred vision but no neurological deficits. His condition improved significantly, and he was discharged two days later. Histopathological analysis confirmed a spindle cell tumor without atypia or necrosis, indicating a benign nature. Fourteen articles were found on PubMed. After excluding two non-English articles, 12 were screened, but none mentioned "meningioma" indicating a lack of relevant literature.
Conclusion:
Pineal tumors can present with subarachnoid hemorrhage, and surgical resection yielded a favorable outcome.