bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid MEMS-CMOS ion traps for NISQ computing
Authors: Blain M G , Haltli R , Maunz P , Nordquist C D , Revelle M , Stick D 
Published: May 2021

Abstract
Surging interest in engineering quantum computers has stimulated significant and focused research on technologies needed to make them manufacturable and scalable. In the ion trap realm this has led to a transition from bulk three-dimensional macro-scale traps to chip-based ion traps and included important demonstrations of passive and active electronics, waveguides, detectors, and other integrated components. At the same time as these technologies are being developed the system sizes are demanding more ions to run noisy intermediate scale quantum (NISQ) algorithms, growing from around ten ions today to potentially a hundred or more in the near future. To realize the size and features needed for this growth, the geometric and material design space of microfabricated ion traps must expand. In this paper we describe present limitations and the approaches needed to overcome them, including how geometric complexity drives the number of metal levels, why routing congestion affects the size and location of shunting capacitors, and how RF power dissipation can limit the size of the trap array. We also give recommendations for future research needed to accommodate the demands of NISQ scale ion traps that are integrated with additional technologies.
Macromechanics and two-body problems
Authors: Wang Huai-Yu 
Published: May 2021

AbstractA wave function can be written in the form ofReiS/ℏ. We put this form of wave function into quantum mechanics equations and take hydrodynamic limit, i. e., let Planck constant be zero. Then equations of motion (EOM) describing the movement of macroscopic bodies are retrieved. From Schrödinger equation, we obtain Newtonian mechanics, including Newton’s three laws of motion; from decouple Klein–Gordon equation with positive kinetic energy (PKE), we obtain EOM of special relativity in classical mechanics. These are for PKE systems. From negative kinetic energy (NKE) Schrödinger equation and decoupled Klein–Gordon equation, the EOM describing low momentum and relativistic motions of macroscopic dark bodies are derived. These are for NKE systems, i. e., dark systems. In all cases scalar and vector potentials are also taken into account. The formalism obtained is collectively called macromechanics. For an isolated system containing PKE and NKE bodies, both total momentum and total kinetic energy are conserved. A dark ideal gas produces a negative pressure, and its microscopic mechanism is disclosed. Two-body problems, where at least one is of NKE, are investigated for both macroscopic bodies and microscopic particles. A NKE proton and a PKE electron can compose a stable PKE atom, and its spectral lines have blue shifts compared to a hydrogen atom. The author suggests to seek for these spectral lines in celestial spectra. This provides a way to seek for dark particles in space. Elastic collisions between a body and a dark body are researched.
Research on the application of artificial intelligence method in automobile engine fault diagnosis
Authors: Du Canyi , Li Wen , Rong Ying , Li Feng , Yu Feifei , Zeng Xiangkun 
Published: May 2021

Abstract
The application of artificial intelligence methods in fault diagnosis is becoming more and more extensive, and exploring and researching intelligent fault diagnosis methods for automobile engines is also a hot spot in the field of automotive engineering. Different machine learning methods have their own advantages and disadvantages. By extracting different characteristic parameters and optimizing the combination of multiple algorithms, faster and stable diagnosis results can be achieved, so that faults can be discovered and repaired in time. Aiming at the potential fluctuation and impact characteristics of vibration plus signal caused by different failure states of automobile engines, this paper proposes two engine fault identification methods using vibration acceleration signals as diagnostic parameters. They are Cross Validation -Support Vector Machine (CV-SVM)and Particle Swarm Optimization-Probabilistic Neural Network (PSO-PNN) engine fault identification methods. The advantages and disadvantages of the two methods are compared and analyzed. Obtain the amplitude corresponding to the frequency multiplication of the vibration acceleration signal through the spectrum analysis method, which is used as the main component of the input feature vector, and establish the SVM fault diagnosis model combined with the cross-validation method (CV); In addition, multiple one-dimensional arrays composed of time-domain signals are directly used as input feature vectors, and the particle swarm optimization (PSO) parameter optimization is used to obtain the best Probabilistic Neural Network(PNN) fault diagnosis model. The results show that both the CV-SVM (small sample) method and the PSO-PNN method (large sample) can realize the identification and diagnosis of the established engine fault type. The CV-SVM method has more advantages in diagnostic fault tolerance, but the PSO-PNN method can simplify the process of feature sample preparation, save a lot of manual feature extraction tasks, and is more convenient in practical application.
Association of postoperative infection and oncological outcome after breast cancer surgery
Authors: Adwall L , Pantiora E , Hultin H , Norlén O 
Published: May 2021

Abstract

Background
Surgical-site infection (SSI) is a well known complication after breast cancer surgery and has been reported to be associated with cancer recurrence. The aim of this study was to investigate the association between SSI and breast cancer recurrence, adjusting for several known confounders. The secondary aim was to assess a possible association between any postoperative infection and breast cancer recurrence.

Method
This retrospective cohort study included all patients who underwent breast cancer surgery from January 2009 to December 2010 in the Uppsala region of Sweden. Data collected included patient, treatment and tumour characteristics, infection rates and outcome. Association between postoperative infection and oncological outcome was examined using Kaplan–Meier curves and Cox regression analysis.

Results
Some 492 patients (439 with invasive breast cancer) with a median follow-up of 8.4 years were included. Mean(s.d.) age was 62(13) years. Sixty-two (14.1 per cent) of those with invasive breast cancer had an SSI and 43 (9.8 per cent) had another postoperative infection. Some 26 patients had local recurrence; 55 had systemic recurrence. Systemic recurrence was significantly increased after SSI with simple analysis (log rank test, P = 0.035) but this was not observed on adjusted analysis. However, tumour size and lymph node status remained significant predictors for breast cancer recurrence on multiple regression. Other postoperative infections were not associated with recurrence.

Conclusion
Neither SSI nor other postoperative infections were associated with worse oncological outcome in this study. Rather, other factors that relate to both SSI and recurrence may be responsible for the association seen in previous studies.
Tracing People Living With Human Immunodeficiency Virus Who Are Lost to Follow-up at Antiretroviral Therapy Programs in Southern Africa: A Sampling-Based Cohort Study in 6 Countries
Authors: Ballif Marie , Christ Benedikt , Anderegg Nanina , Chammartin Frédérique , Muhairwe Josephine , Jefferys Laura , Hector Jonas , van Dijk Janneke , Vinikoor Michael J , van Lettow Monique , Chimbetete Cleophas , Phiri Sam J , Onoya Dorina , Fox Matthew P , Egger Matthias 
Published: May 2021

Abstract

Background
Attrition threatens the success of antiretroviral therapy (ART). In this cohort study, we examined outcomes of people living with human immunodeficiency virus (PLHIV) who were lost to follow-up (LTFU) during 2014–2017 at ART programs in Southern Africa.

Methods
We confirmed LTFU (missed appointment for ≥60 or ≥90 days, according to local guidelines) by checking medical records and used a standardized protocol to trace a weighted random sample of PLHIV who were LTFU in 8 ART programs in Lesotho, Malawi, Mozambique, South Africa, Zambia, and Zimbabwe, 2017–2019. We ascertained vital status and identified predictors of mortality using logistic regression, adjusted for sex, age, time on ART, time since LTFU, travel time, and urban or rural setting.

Results
Among 3256 PLHIV, 385 (12%) were wrongly categorized as LTFU and 577 (17%) had missing contact details. We traced 2294 PLHIV (71%) by phone calls, home visits, or both: 768 (34% of 2294) were alive and in care, including 385 (17%) silent transfers to another clinic; 528 (23%) were alive without care or unknown care; 252 (11%) had died. Overall, the status of 1323 (41% of 3256) PLHIV remained unknown. Mortality was higher in men than women, higher in children than in young people or adults, and higher in PLHIV who had been on ART &lt;1 year or LTFU ≥1 year and those living farther from the clinic or in rural areas. Results were heterogeneous across sites.

Conclusions
Our study highlights the urgent need for better medical record systems at HIV clinics and rapid tracing of PLHIV who are LTFU.
Patterning uncertainty: partial likeness, analogy and likelihood
Authors: Scazzieri Roberto 
Published: May 2021

Abstract
This paper examines the role of similarity judgements in Keynes’s theory of analogy as discussed in the Treatise on Probability (Keynes, 1921) and outlines a conceptual framework in which induction by analogy based on the identification of partial resemblances leads to likelihood as the central disposition by which human actors assign a pattern to uncertainty. The structure of the paper is as follows. Section 2 discusses Keynes’ view of analogy as the foundation of inductive inference. Section 3 outlines a theory of similarity based on Keynes’s criteria of finite variety and negative analogy. Section 4 highlights the relationship between a similarity-based theory of induction and Keynes’ ontological view that similarity features derive from a finite number of ‘generator properties’. Section 5 examines the social structuring of similarity features and the active role of agents in constructing the inductive knowledge of the world they inhabit. Section 6 brings the paper to close by calling attention to the relationship between dispositions, circumstantial visualisation of similarity features and problem-solving actions in the world of practice.
Pruning of Health Data in Mobile-Assisted Remote Healthcare Service Delivery
Authors: Mondal Safikureshi , Mukherjee Nandini 
Published: May 2021

Abstract
The use of cloud computing and mobile devices is increasing in healthcare service delivery primarily because of the huge storage capacity of cloud, the heterogeneous structure of health data and the user-friendly interfaces on mobile devices. We propose a healthcare delivery scheme where a large knowledge base is stored in the cloud and user responses from mobile devices are input to this knowledge base to reach a preliminary diagnosis of diseases based on patients’ symptoms. However, instead of sending every response to the cloud and getting data from cloud server, it may often be desirable to prune a portion of the knowledge base that is stored in a graph form and download in to the mobile devices. Downloading data from cloud depends on the storage, battery power, processor of a mobile device, wireless network bandwidth and cloud processor capacity. In this paper, we focus on developing mathematical expressions involving the above mentioned criteria and show how these parameters are dependent on each other. The expressions built in this paper can be used in real-life scenarios to take decisions regarding the amount of data to be pruned in order to save energy as well as time.
Carcinoid heart disease of gonadal primary presenting with hypoxia: a case report
Authors: O’Driscoll Ronan , Prashar Abhisheik , Youssef George , Sader Mark 
Published: May 2021

Abstract

Background
Carcinoid heart disease is a potential sequela of metastatic neuroendocrine tumour that has characteristic valve appearances. Patients can present with symptoms of carcinoid syndrome or be relatively asymptomatic until symptoms of progressive heart failure manifest.

Case summary
We present a case of a 54-year-old male who was admitted to the hospital for investigation of hypoxia. Transthoracic echocardiogram was suggestive of carcinoid heart disease which subsequently led to a diagnosis of metastatic neuroendocrine (carcinoid) tumour of the testicular primary. Work-up revealed a patent foramen ovale with evidence of the right to left interatrial shunt from severe tricuspid regurgitation as the cause of his hypoxia. Prior to surgical excision of the primary tumour, percutaneous patent foramen ovale closure was performed resulting in improved arterial oxygen saturation and symptomatic improvement.

Discussion
Carcinoid heart disease typically affects the right-sided cardiac valves and the tricuspid valve appearances were critical in leading to a diagnosis of a metastatic neuroendocrine tumour in our patient. This case demonstrates that percutaneous patent foramen ovale closure can be an effective intervention for hypoxia in those not managed surgically. A high index of suspicion should be maintained for gonadal primary carcinoid tumour when there is carcinoid heart disease in the absence of liver metastases.
Shear reflectivity compensation in full-waveform inversion using least-squares reverse-time migration
Authors: Feng Zongcai , Huang Lianjie 
Published: May 2021

SUMMARY
The computational cost of elastic-waveform inversion is too high for inverting PP reflections, while using acoustic full-waveform inversion (FWI) is inaccurate because it does not depend on the shear modulus/velocity/impedance that affects elastic PP wavefield amplitudes. To solve this problem, we develop a waveform inversion method that uses acoustic least-squares reverse-time migration (LSRTM) to compensate the shear reflectivity for acoustic FWI. Our method is based on the quasi-elastic-wave equation developed by Chapman et al. (2014). The quasi-elastic-wave equation uses a linearized acoustic-wave equation with shear modulus μ as a virtual source to correct the acoustic PP wavefield amplitudes toward elastic ones. Our waveform inversion method inverts for elastic parameters by minimizing the L2 norm of the difference between recorded and predicted PP reflections modelled using the quasi-elastic-wave equation. Numerical tests on synthetic and field data show that our method can properly handle the amplitudes of elastic PP reflections and provides an accurate estimate of the P- and S-wave velocities/impedances and, in some cases, the density. The method does not need the computationally expensive numerical solution to the elastic-wave equation. It also gives a better estimate of elastic parameters than a pure LSRTM method for elastic PP reflections.
Trends in U.S. Health Care Spending on Inflammatory Bowel Diseases, 1996-2016
Authors: Singh Siddharth , Qian Alexander S , Nguyen Nghia H , Ho Stephanie K M , Luo Jiyu , Jairath Vipul , Sandborn William J , Ma Christopher 
Published: May 2021

Abstract

Background
Inflammatory bowel diseases (IBD) are rising in prevalence and are associated with high health care costs. We estimated trends in U.S. health care spending in patients with IBD between 1996 and 2016.

Methods
We used data on national health care spending developed by the Institute for Health Metrics and Evaluations for the Disease Expenditure Project. We estimated corresponding U.S. age-specific prevalence of IBD from the Global Burden of Diseases Study. From these 2 sources, we estimated prevalence-adjusted, temporal trends in U.S. health care spending in patients with IBD, stratified by age groups (&lt;20 years, 20-44 years, 45-64 years, ≥65 years) and by type of care (ambulatory, inpatient, emergency department [ED], pharmaceutical prescriptions, and nursing care), using joinpoint regression, expressed as an annual percentage change (APC) with 95% confidence intervals.

Results
Overall, annual U.S. health care spending on IBD increased from $6.4 billion (95% confidence interval, 5.7-7.4) in 1996 to $25.4 billion (95% confidence interval, 22.4-28.7) in 2016, corresponding to a per patient increase in annual spending from $5714 to $14,033. Substantial increases in per patient spending on IBD were observed in patients aged ≥45 years. Between 2011 and 2016, inpatient and ED care accounted for 55.8% of total spending and pharmaceuticals accounted for 19.9%, with variation across age groups (inpatient/ED vs pharmaceuticals: ages ≥65 years, 57.6% vs 11.2%; ages 45-64 years, 49.5% vs 26.9%; ages 20-44 years, 59.2% vs 23.6%).

Conclusions
Even after adjusting for rising prevalence, U.S. health care spending on IBD continues to progressively increase, primarily in middle-aged and older adults, with unplanned health care utilization accounting for the majority of costs.
Brucella Outer Membrane Lipoproteins 19 and 16 Differentially Induce Interleukin-18 Response or Pyroptosis in Human Monocytic Cells
Authors: Ren Hui , Yang Heng , Yang Xin , Zhang Guoxia , Rong Xia , Huang Jiaheng , Zhang Ling , Fu Yongshui , Allain Jean-Pierre , Li Chengyao , Wang Wenjing 
Published: May 2021

Abstract

Background
Brucella species are Gram-negative intracellular bacteria that causes severe inflammatory diseases in animals and humans. Two major lipoproteins (L19 and L16) of Brucella outer membrane proteins were studied to explore the association with inflammatory response of human monocytes (THP-1).

Methods
Activated THP-1 cells induced with recombinant L19 and L16 were analyzed in comparison with unlipidated forms (U19 and U16) and lipopolysaccharide (LPS) of Brucella melitensis, respectively.

Results
Secretion of inflammatory factors tumor necrosis factor-α, interleukin (IL)-6, and IL-1β was significantly increased from L19, L16, or both stimulated THP-1 cells. High secretion of IL-18 was detected only from L19-induced cells. Signaling of those cytokine responses was identified mainly through the P38-mitogen-activated protein kinase pathway, and signaling of L19-induced IL-1β response partly occurred via necrosis factor-κB. While exploring different forms of IL-18, we found that L19-induced production of active IL-18 (18 kD) occurred through upregulating NLRP3 and activating caspase-1, whereas L16-induced production of inactive IL-18 fragments (15 kD and 16 kD) occurred through activating caspase-8/3. We also found that L19 upregulated phosphorylation of XIAP for inhibiting caspase-3 activity to cleave IL-18, whereas L16 activated caspase-3 for producing GSDME-N and leading to pyroptosis of THP-1 cells.

Conclusions
Brucella L19 and L16 differentially induce IL-18 response or pyroptosis in THP-1 cells, respectively.
Investment Motives in Africa: What Does the Meta-Analytic Review Tell?
Authors: Anwar Amar , Iwasaki Ichiro , Dornberger Utz 
Published: May 2021

AbstractOver the past two decades, Africa has witnessed a dramatic increase in foreign direct investment (FDI) despite a lack of significant changes in infrastructure and the host country’s policies. What are the motives to invest in Africa? How do these investment motives differ for firms from developed and emerging markets? Several studies empirically tested these questions, however, provided inconclusive results. By taking 735 estimates extracted from 51 studies and applying advanced meta-analysis techniques, this study examines the motives of FDI in Africa. We found that compared to market-seeking motive, the effect size of resource seeking and efficiency seeking is larger (smaller) on FDI attractiveness in Africa. In terms of effect size, the impact of asset-seeking motive on FDI is statistically comparable to that of market-seeking motive. Contrary to general perceptions, the impact of natural resources on FDI attractiveness in Africa is not different from market seeking for developed countries’ firms. Our results show that compared to GDP per capita, the effect size of accessing minerals and oil reserves on FDI attractiveness in Africa is positive and significant for global and emerging market firms. Our research shows that there is more likelihood of type I and type II publication selection bias in this research field.
Clinical Validation of a Novel Quality Management System for Blood Gas, Electrolytes, Metabolites, and CO-Oximetry
Authors: Nichols James H , Cambridge Tony , Sanchez Neldis , Marshall Debra 
Published: May 2021

Abstract

Background
Quality management of point-of-care (POC) blood gas testing focuses on verifying instrument accuracy and precision, in addition to performing daily quality control (QC) checks every 8 h and with each patient test (unless internal calibration is verified every 30 min). At the POC, a risk-based approach is suitable to address both systemic and transient sample-specific errors that may negatively impact patient care.

Methods
We evaluated the performance of the GEM® Premier™ 5000 with next generation Intelligent Quality Management 2 (iQM®2) (Instrumentation Laboratory, Bedford, MA), from the analysis of approximately 84,000 patient samples across 4 sites. Continuous iQM2 was compared to intermittent liquid QC, either manual or automated, at 2 sites. Analysis of error flags for patient samples and statistical characteristics of QC processes, including method sigma and average detection time (ADT) for an error, were examined.

Results
ADT was approximately 2 min with iQM2 and varied from hours to days with intermittent QC. iQM2 Process Control Solutions (PCS) precision was similar or better (&gt;6 sigma for all analytes) than manual (sigma 3.0 for pO2) or automated internal QC (sigma 1.3 for tHb and sigma 3.3 for pO2). In addition, iQM2 detected errors in ∼1.4% of samples, providing an additional safeguard against reporting erroneous results.

Conclusions
The findings in this study demonstrate excellent performance of the GEM Premier 5000 with iQM2 including &gt;6 sigma precision for all analytes and faster error detection times. These benefits address risk in different phases of testing that are not easily detected by intermittent performance of liquid QC (manual or automated).