bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to and facilitators of implementation of the integration of oncology and palliative care in daily practice: a systematic review
Authors: Uneno Yu , Horie Yoshiki , Kataoka Yuki , Mori Masanori , Hirakawa Mami , Suzuki Takaaki , Nakajima Takako Eguchi , Shimizu Chikako , Tsuneto Satoru , Morita Tatsuya , Muto Manabu 
Published: April 2021

Abstract
Background: Palliative care (PC) is widely recognized as an essential part of oncology care, and multiple academic societies have developed strong recommendations regarding the implementation of the integration of oncology and PC (IOP) in daily practice. However, IOP implementation is a slow- evolving process, and its barriers and facilitators have not yet been comprehensively identified. This systematic review aimed to clarify the barriers to and facilitators of IOP in the context of treating patients with advanced cancer.Methods: We searched Ovid MEDLINE, Embase, and Cumulative Index of Nursing and Allied Health Literature until June 3, 2017. We included original articles, narrative and systematic reviews, guidelines, editorials, commentaries, and letters. After title and abstract screening by two of five independent reviewers, we analyzed the data qualitatively using inductive content analysis and a consolidated framework for implementation research. Results: We obtained 3,304 articles, of which 60 met the predefined eligibility criteria. The numbers and proportions of original and review articles, guidelines, and other article types were 21 (35%), 30 (50%), 3 (5%), and 7 (12%), respectively. Five categories emerged regarding both the barriers to and facilitators of IOP: intervention characteristics, outer settings, inner settings, individual characteristics, and process. The representative barriers were limited availability of and access to PC services, limited educational opportunities for PC providers, insufficient reimbursement and research funding toward PC services, focus on cure rather than care (patients and their caregivers), and insufficient communication between oncology and PC staff (n = 26, 16, 14, 13, and 7, respectively). The representative facilitators were improvement of the availability of and access to PC services, development of an optimal integrated care model, enrichment of educational opportunities regarding PC (healthcare professionals), and initiatives by government and academic societies (n = 24, 18, 25, and 7, respectively).Conclusions: This study clarified the multi-level barriers to and facilitators of the implementation of IOP. Educational and financial support from the government and academic societies appears essential, and further effort to develop and investigate the implementable care delivery model is warranted.Registration: PROSPERO:CRD42018069212
Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine
Authors: Teekayupak Kanyapat , Ruecha Nipapan , Chailapakul Orawon , Rodthongkum Nadnudda 
Published: April 2021

Abstract
We report on the development of an electrochemical sensor platform based on modified cotton fibers for the non-enzymatic detection of uric acid (UA), an important biomarker for gout disease. To create the flexible electrode, a cotton thread was coated with carbon ink followed by the electrodeposition of AuNPs. Then, differential pulse voltammetry (DPV) was used to evaluate the sensor performances, and a linear detection range between 10 µM and 5.0 mM of uric acid was obtained. The sensor has a low detection limit of 0.12 µM, which is optimal for use in the patients suffering from gout disease which commonly experience concentrations of uric acid in urine higher than 4.46 mM. Furthermore, we found that the detection sensitivity of the platform was not affected by the presence of other physiological compounds present in human urine. The described platform has the potential for integration in a diaper hence enabling rapid detection and screening for gout disease.
Competitive Blocking of Salivary Gland [18F]DCFPyL Uptake via Localized, Retrograde Ductal Injection of Non-radioactive DCFPyL: A Preclinical Study
Authors: Roy Jyoti , Warner Blake M , Basuli Falguni , Zhang Xiang , Zheng Changyu , Goldsmith Corrine , Phelps Tim , Wong Karen , Ton Anita T , Pieschl Rick , White Margaret E , Swenson Rolf , Chiorini John A , Choyke Peter L , Lin Frank I 
Published: April 2021

Abstract
BACKGROUNDPSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa) but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [18F]DCFPyL as a surrogate for PSMA-TRT, we report a novel method to selectively reduce salivary gland (SG) uptake of systemically administered [18F]DCFPyL by immediate prior infusion of non-radioactive standard of [18F]DCFPyL (DCFPyL) directly into the SG via retrograde cannulation. METHODSA dose-finding cohort using athymic nude mice demonstrated proof-of-principle that SG uptake can be selectively blocked by DCFPyL administered either locally via cannulation (CAN group) or systemically (SYS group). The experiments were repeated in a validation cohort of 22RV1 tumor-bearing mice. Submandibular glands (SMG) of CAN mice were locally blocked with either saline or DCFPyL (dose range: 0.01x to 1000x molar equivalent of the radioactive [18F]DCFPyL dose). The radioactive dose of [18F]DCFPyL was administered systemically 10 minutes later and the mice euthanized after 1 hour for biodistribution studies. Toxicity studies were done at up to 1000x dose. RESULTSIn the dose-finding cohort, the SYS group showed a dose-dependent 12-40% decrease in both the SMG T:B and the kidney (tumor surrogate). Mild blocking was observed at 0.01x, with maximal blocking reached at 1x with no additional blocking up to 1000x. In the CAN group, blocking at the 0.1x and 1x dose levels resulted in a similar 42-53% decrease, but without the corresponding decrease in kidney uptake as seen in the SYS group. Some evidence of “leakage” of DCFPyL from the salivary gland into the systemic circulation was observed. However, experiments in 22RV1 tumor-bearing mice at the 0.1x and 1x dose levels confirm that, at the appropriate blocking dose, SG uptake of [18F]DCFPyL can be selectively reduced without affecting tumor uptake and with no toxicity.CONCLUSIONOur results suggest that direct retrograde instillation of DCFPyL into the SG could predictably and selectively decrease salivary uptake of systemically administered [18F]DCFPyL without altering tumor uptake, if given at the appropriate dose. This novel approach is easily translatable to clinical practice and has the potential to mitigate xerostomia, without compromising the therapeutic efficacy of the PSMA-TRT.
Strong constraints from COSINE-100 on the DAMA dark matter results using the same sodium iodide target
Authors: Adhikari Govinda , de Souza E. Barbosa , Carlin N. , Choi J.J. , Choi S. , Djamal M. , Ezeribe Anthony C. , Franca L.E. , Ha C. , Hahn I.S. , Jeon E.J. , Jo J.H. , Joo H.W. , Kang W.G. , Kauer M. , Kim H. , Kim H.J. , Kim K.W. , Kim S.H. , Kim S.K. , Kim W.K. , Kim Y.D. , Kim Y.H. , Ko Young Ju , Lee E.K. , Lee H. , Lee Hyun Su , Lee H.Y. , Lee I.S. , Lee J , Lee J.Y. , Lee M.H. , Lee S.H. , Lee S.M. , Leonard D , Manzato B. , Maruyama R. , Neal R. , Olsen S. , Park B.J. , Park H.K. , Park H.S. , Park K.S. , Pitta R. , Prihtiadi H. , Ra SeJin , Rott C. , Shin K.A. , Scarff A. , Spooner N. , Thompson William , Yang L. , Yu G.H. 
Published: April 2021

Abstract
It is a long-standing debate as to whether or not the annual modulation in the event rate observed by the DAMA sodium iodide experiment is caused by the interaction of dark matter particles. To resolve this issue, several groups have been working to develop new experiments with the aim of reproducing or refuting DAMA's results using the same sodium iodide target medium. The COSINE-100 experiment is one of these that is currently operating with 106 kg of low-background sodium iodide crystals at the Yangyang underground laboratory. Analysis of the initial 59.5 days of COSINE-100 data showed that the annual modulation signal reported by DAMA is inconsistent with explanation using spin-independent interaction of weakly interacting massive particles
(WIMPs), a favored candidate of dark matter particles, with sodium or iodine nuclei in the context of the standard halo mode. However, this first result left open interpretations using certain alternative dark matter models, dark matter halo distributions, and detector responses that could allow room for consistency between DAMA and COSINE-100. Here we present new results from over 1.7 years of COSINE-100 operation with improved event selection and energy threshold reduced from 2 keV to 1 keV. We find an order of magnitude improvement in sensitivity, sufficient for the first time to strongly constrain these alternative scenarios, as well as to further strengthen the previously observed inconsistency with the WIMP-nucleon spin-independent interaction hypothesis.
A lightweight strain-glass alloy showing nearly temperature-independent low modulus and high strength
Authors: Liu Chang , Tang Jingxian , Ji Yuanchao , Otsuka Kazuhiro , Wang Yu , Hou Mengrui , Hao Yanshuang , Ren Shuai , Ren Xiaobing 
Published: April 2021

Abstract
Fast development of space technologies poses a strong demand for elastic materials that are lightweight, strong, but compliant to achieve high density of elastic energy storage, and such properties need to be temperature-insensitive in space environments1-4. However, existing materials do not meet this demand. Here we report a lightweight magnesium-scandium (Mg-21.3 at. % Sc) alloy meeting this demand. It is as light and compliant as organic-based materials like bones and glass fiber reinforced plastics, but stronger than them5-7; thus, it exhibits a record-high elastic energy density ~0.5 kJ/kg among various metallic and organic-based composite materials at a moderate stress level of 200 MPa8,9. Importantly, the performance can persist for 1 million stress cycles and over a wide temperature range from ambient to cryogenic temperatures. Its exceptional properties stem from a strain-glass transition. In-situ microstructure observations during cooling show strain-glass nanodomains continuously form from the matrix phase, which enables low modulus, high strength, fatigue-resistance, and temperature-insensitivity. The lightweight strain-glass Mg-Sc alloy may find applications in space technologies and other fields such as orthopedics1,9-11.
Deciphering the Mutation Spectrum in South Indian Children With Congenital Anomalies of the Kidney and Urinary Tract
Authors: Narikot Ambili , Pardeshi Varsha Chhotusing , AM Shubha , Iyengar Arpana , Vasudevan Anil 
Published: April 2021

Abstract
Background: Congenital anomalies of the kidney and urinary tract (CAKUT) cover a spectrum of structural malformations that result from aberrant morphogenesis of kidney and urinary tract. It is the most prevalent cause of kidney failure in children. Hence, it is important from a clinical perspective to unravel the molecular etiology of kidney and urinary tract malformations. Causal variants in genes that direct various stages of development of kidney and urinary tract in fetal life have been identified in 5–20 % of CAKUT patients from Western countries. Recent advances in next generation sequencing technology and decreasing cost offer the opportunity to characterize the genetic burden of CAKUT in Indian population and facilitate integration of genetic diagnostics in care of children with CAKUT. Methods: Customized targeted panel sequencing was performed to identify mutations in 31 genes known to cause human CAKUT in 69 south Indian children with CAKUT. The NGS data was filtered using standardized pipeline and the variants were classified using ACMG criteria. Genotype and phenotype correlations were performed. Results: The cohort consisted of children mostly with posterior urethral valve (PUV) (39.1%), vesico-ureteric reflux (VUR) (33.3%) and multi-cystic dysplastic kidney (MCDK) (7.2%). Likely pathogenic variants were identified in two genes (TNXB and CHD1L) in 2 children (9 %) with CAKUT. One child diagnosed with posterior urethral valve (PUV) had mutation in two different genes [TNXB (p. Gln286fs), and CHD1L (p. Ser837fs)], while second child with left duplex system had a single gene mutation in TNXB gene (p. Gln286fs). Conclusions: The present study identified novel monogenic mutations in only a small proportion of patients with CAKUT using a targeted gene panel. The low prevalence of genetic cause may be due to higher proportion of children with abnormalities in lower urinary tract than hypodysplasia of kidneys. Clinical or whole exome sequencing may be a better method to characterize the genetic profile of Indians patients with CAKUT.
Patch loaded slot antenna for super wideband applications with dual-band notch characteristic
Authors: agrawal sachin , Wani Zamir , Parihar Manoj Singh 
Published: April 2021

Abstract
This paper presents a patch loaded slot antenna for super wideband

(SWB) application. To obtain SWB characteristic, the proposed antenna geometry combined a rectangular slot and an overlying patch excited by a trident shaped microstrip feed. It is observed that the hybrid nature of the proposed antenna effectively enhances the impedance bandwidth up to 120%, by combining the resonance of both patch and slot. Besides, it is investigated that after converting the conventional tapered feed into the trident shape feed, the impedance bandwidth is increased further from 120% to 167% ranging between 1.25 to 15 GHz. Moreover, one U-shaped slot and two L-shaped stubs

are inserted into the antenna design to introduce the dual-band rejection property from 1.8 to 2.4 GHz (GSM 1800, Wi-Fi 2.1 and 2.4) and 3.1 to 4.2 GHz (WiMAX and C-band). Further, to validate the simulation results a prototype is fabricated and tested. The measured result shows that the proposed antenna offered an impedance bandwidth of 170.3% from 1.2 GHz to 15 GHz.
Accelerated remodeling of the mesophyll-bundle sheath interface in the maize C4 cycle mutant leaves
Authors: Gao Peng , Wang Pengfei , Du Baijuan , Li Pinghua , Kang Byung-Ho 
Published: April 2021

Abstract
C4 photosynthesis in the maize leaf involves the exchange of organic acids between mesophyll (M) and the bundle sheath (BS) cells. The transport is mediated by plasmodesmata embedded in the suberized cell wall. We examined the maize Kranz anatomy with a focus on the plasmodesma and cell wall suberization with microscopy methods. In the young leaf zone where M and BS cells had indistinguishable proplastids, plasmodesmata were simple and no suberin was detected. In leaf zones where dimorphic chloroplasts were evident, the plasmodesma acquired sphincter and cytoplasmic sleeves, and suberin was discerned. These modifications were accompanied by a drop in symplastic dye mobility at the M-BS boundary. We compared the kinetics of chloroplast differentiation and the modifications in M-BS connectivity in ppdk and dct2 mutants where C4 cycle is affected. The rate of chloroplast diversification did not alter, but plasmodesma remodeling, symplastic transport inhibition, and cell wall suberization were observed from younger leaf zone in the mutants than in wild type. Our results indicate that inactivation of the C4 genes accelerated the changes in the M-BS interface and the reduced permeability suggests that symplastic transport between M and BS could be gated probably for suppressing erroneous flux of C4 metabolites.
Mesenchymal Stem Cell Therapy Ameliorates Metabolic Dysfunction and Restores Fertility in a PCOS Mouse Model Through Interleukin-10
Authors: Chugh Rishi Man , Park Hang-soo , Andaloussi Abdeljabar El , Elsharoud Amro , Esfandyari Sahar , Ulin Mara , Bakir Lale , Aboalsoud Alshimaa , Ali Mohamed , Ashour Dalia , Igboeli Prosper , Ismail Nahed , McAllister Jan , Al-Hendy Ayman 
Published: April 2021

Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features of PCOS. Human bone marrow mesenchymal stem cells (BM-hMSC) and their secreted factors (secretome) exhibit robust anti-inflammatory capabilities in various biological systems. We evaluated the therapeutic efficacy of BM-hMSC and its secretome in both in vitro and in vivo PCOS models.Methods: For in vitro experiment, we treated conditioned media from BM-hMSC to androgen producing H293R cells, and analyzed androgen producing gene expression. For in vivo experiment, BM-hMSC were implanted into Letrozole (LTZ) induced mouse PCOS model. BM-hMSC effect in androgen producing cells or PCOS model mice was assessed by monitoring cell proliferation (immunohistochemistry), steroidogenic gene expression (quantitative real-time polymerase chain reaction [qRT-PCR] and Western blot, animal tissue assay (H&E staining), and fertility by pup delivery.Results: BM-hMSC significantly downregulate steroidogenic gene expression, curb inflammation, and restore fertility in treated PCOS animals. The anti-inflammatory cytokine interleukin-10 (IL-10) played a key role in mediating the effects of BM-hMSC in our PCOS models. We demonstrated that BM-hMSC treatment was improve in metabolic and reproductive markers in our PCOS model and able to restore fertility. Conclusion: Our study demonstrates for the first time the efficacy of intra-ovarian injection of BM-hMSC or its secretome to treat PCOS-related phenotypes, including both metabolic and reproductive dysfunction. This approach may represent a novel therapeutic option for women with PCOS. Our results suggest that BM-hMSC can reverse PCOS-induced inflammation through IL-10 secretion. BM-hMSC might be a novel and robust therapeutic approach for PCOS treatment.
Bacteria Associated With Commercially Prepared Mealie Meal From Selected Food Stores in Lusaka District of Zambia
Authors: Omodele Adeyemo Dayo , Mudenda Hangombe Bernard , Muma John Bwalya , Munyeme Musso , Simuunza Martin , Abike Adewolu Mosunmola , Adedayo Adetayo 
Published: April 2021

Abstract
Introduction:Mealie meal is a staple diet in the Lusaka district of Zambia. Bacteria associated with commercially prepared mealie meal could be spoilage or pathogenic bacteria. Thus bacterial contamination could result from packaged maize flours purchased from food stores.Material and Methods:A cross-sectional study was carried out from December 2019 - March 2020 for spoilage and pathogenic bacteria associated with mealie meals bought from a selected retail outlet in the Lusaka district. We performed cell culture for the Mealie Meal Samples collected at five study zones in Lusaka district viz: South, Central, East, West, and North. Food stores in each zone were further stratified into sampling units of interest: mall, shop, and street food vendor. Results: Preliminary laboratory findings revealed the following: Spoilage Bacteria - Candida Species, Clostridium Species, and Bacillus Species; Pathogenic Bacteria Species-Clostridium perfringens, Staphylococcus aureus, Clostridium tetani, Bacillus, Escherichia coli, Pseudomonas aeruginosa, and Yersinia pestis.Conclusion:In conclusion, it can be established from the aforementioned laboratory results that food-borne infections could evolve from bacteria associated with commercially prepared mealie meals bought from food stores in the Lusaka district of Zambia.
Experimental and Numerical Study of Cold Helical Rolling of Small-Diameter Steel Balls
Authors: Liu Shengqiang , Liu Jinping , Xu Hao , Wang Zhipeng , Shen Jinxia , Wang Baoyu 
Published: April 2021

Abstract
Cold helical rolling (CHR) is one of the most effective ways to produce small-diameter steel balls. In this study, one kind of work hardening model was established and implemented into Simufact 15.0 to investigate the work hardening phenomenon in the cold forming process. Firstly, based on the helical rolling theory, a set of finite element (FE) simulations was developed. The influence of CHR parameters, including the starting height of convex rib, forming area length, and rolling inclination angle, on the forming process was studied via simulation. Furtherly, the CHR process experiments and FE simulation were carried out , the results showed that the FE simulation was in good agreement with the experimental results, and consistent with the predicted value of the theoretical calculation. Finally, the evolution of effective strain, effective stress, rolling force, work hardening and microstructure during the cold helical rolling of Φ 5.12 mm steel balls was investigated via FE. As result, the evolution trend of hardness was consistent with that of dislocation density, indicating that the model is credible. Besides, the microstructure of the steel ball at different positions further verified this.
WITHDRAWN: Genetic Analysis and Gene Mapping of Two Whitebacked Planthopper Resistance Genes From Rice Varieties
Authors: Cheng Ling , Nong Baoxuan , Xu Anlong , He Wenai , Wu Biqiu , QIU Yongfu 
Published: April 2021

Abstract
Background The whitebacked planthopper (WBPH) has become a significant threat to rice production. Identification of WBPH-resistant germplasm and genes can drive efforts to develop resistance varieties and effectively limit pest damage.Methods Fourteen varieties of rice were surveyed for insect resistance using tests that assessed bulk seedling growth rates, insect feeding activity (via measurements of honeydew excretion weight), and insect development (by counting the number of hatched nymphs). Two resistance varieties N22 and OB677 were crossed with susceptible line 9311 to develop mapping populations, which were applied to map the resistance genes/QTLs.Results The rice variety PTB33 showed high resistance to both brown planthopper (BPH) and WBPH, and varieties N22, RBPH327, and OB677 showed moderate resistance to WBPH. Host choice test and seedling survival rates further verified the WBPH resistance of PTB33, N22, and OB677. By using two F2 mapping populations, two major resistance genes were detected in N22 and OB677. Wbph1 was mapped on chromosome 2 of N22 in a region that harbored the markers RM13650 and RM13478. Its largest logarithm of the odds (LOD) score was 3.94, which explained a 16.6% phenotypic variation. Wbph9 was mapped on chromosome 3 of OB677, where it was flanked by markers RM3513 and RM3525. It had a LOD score of 3.4, explaining a 17.2% phenotypic variation.Conclusions Four varieties PTB33, N22, RBPH327, and OB677 showed resistance to WBPH, of which OB677 was a novel resistance germplasm; and a novel resistance gene Wbph9 was mapped on chromosome 3.