bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fruiting character variability in wild individuals of Malania oleifera, a highly valued endemic species
Authors: Wang Si-Hai , Chen Jian , Yang Wei , Hua Mei , Ma Yong-Peng 
Published: December 2021

AbstractMalania oleifera (Olacaceae), a tree species endemic to Southwest China, has seed oils enriched with nervonic acid and is therefore good source of this chemical. Because of this, there are promising industrial perspective in the artificial cultivation and use of this species. Understanding the variability in the fruit characters among individuals forms the basis or resource prospection. In the current investigation, fifty-three mature fruiting trees were sampled from two locations with divergent climates (Guangnan and Funing). Morphological characterization of fruits (fruit and stone weight, fruit transverse and longitudinal diameter, stone transverse and longitudinal diameter) was conducted, and the concentration of seed oil and its fatty acid composition were also analyzed in all individuals. Differences in all the morphological characters studied were more significant among individual trees than between different geographic localities, even though these had different climates. Eleven fatty acids were identified contributing between 91.39 and 96.34% of the lipids, and the major components were nervonic acid (38.93–47.24%), octadecenoic acid (26.79–32.08%), docosenoic acid (10.94–17.24%). The seed oil content (proportion of oil in seed kernel) and the proportion of nervonic acid were both higher in Funing, which has a higher average climatic temperature than Guangnan. The concentrations of nervonic acid and octadecenoic acid with the low coefficients of variation in the seed oil of M. oleifera were relatively stable in contrast to the other fatty acids. There were significant positive correlations between fruit morphological characters, but the amount of seed oil and the concentrations of its components were not correlated with any morphological character. This study provides an understanding of morphological variation in wild M. oleifera individuals. Wild individuals with excellent fruit traits could be selected and would make promising candidates for commercial cultivation.
Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes
Authors: Ngarmukos Srihatach , Tanavalee Chotetawan , Amarase Chavarin , Phakham Suphattra , Mingsiritham Warayapa , Reantragoon Rangsima , Leearamwat Nitigorn , Kongkaew Thidarat , Tharakhet Kittipan , Honsawek Sittisak , Dechsupa Sinsuda , Tanavalee Aree 
Published: December 2021

AbstractWe compared two and four intra-articular injections of platelet-rich plasma (PRP) in terms of changes of synovial cytokines and clinical outcomes. One hundred twenty-five patients having knee osteoarthritis (OA) underwent PRP injections at a 6-week interval. Before each PRP injection, synovial fluid aspiration was collected for investigation. Patients were divided into two or four intra-articular PRP injections (group A and B, respectively). Changes in synovial biomarkers were compared with the baseline levels of both groups, and clinical outcomes were evaluated until one year. Ninety-four patients who had completed synovial fluid collection were included for final evaluation, 51 in group A and 43 in group B. There were no differences in mean age, gender, body mass index (BMI), and radiographic OA grading. The average platelet count and white blood cell count in PRP were 430,000/µL and 200/ µL, respectively. There were no changes of synovial inflammatory cytokines (IL-1β, IL-6, IA-17A, and TNF-alpha), anti-inflammatory cytokines (IL-4, IL-10, IL-13, and IL-1RA), and growth factors (TGF-B1, VEGF, PDGF-AA, and PDGF-BB) between baseline levels and six weeks in group A, and 18 weeks in group B. Both groups had significantly improved clinical outcomes from six weeks including visual analog scale (VAS), patient-reported outcome measures [PROMs; Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index and Short Form-12 (SF-12)], with a significant delayed improvement of performance-based measures [PBMs; time up and go (TUG), 5-time sit to stand test (5 × SST), and 3-min walk test (3-min WT)]. In conclusion, two- or four-PRP intra-articular injection at a 6-week interval for knee OA demonstrated no changes of synovial cytokines and growth factors but similarly improved clinical outcomes from 6 weeks until 1 year.
Effect of reward on electrophysiological signatures of grid cell population activity in human spatial navigation
Authors: Wang Wenjing , Wang Wenxu 
Published: December 2021

AbstractThe regular equilateral triangular periodic firing pattern of grid cells in the entorhinal cortex is considered a regular metric for the spatial world, and the grid-like representation correlates with hexadirectional modulation of theta (4–8 Hz) power in the entorhinal cortex relative to the moving direction. However, researchers have not clearly determined whether grid cells provide only simple spatial measures in human behavior-related navigation strategies or include other factors such as goal rewards to encode information in multiple patterns. By analysing the hexadirectional modulation of EEG signals in the theta band in the entorhinal cortex of patients with epilepsy performing spatial target navigation tasks, we found that this modulation presents a grid pattern that carries target-related reward information. This grid-like representation is influenced by explicit goals and is related to the local characteristics of the environment. This study provides evidence that human grid cell population activity is influenced by reward information at the level of neural oscillations.
Response analysis of orthotropic steel deck pavement based on interlayer contact bonding condition
Authors: Wang Xuntao , Zhang Changhao , Sun Ruijuan 
Published: December 2021

AbstractIn this research the interlayer contact condition was considered between the adjacent layers of orthotropic steel deck pavement, and an interface contact bonding model was applied to simulate the interlayer bonding condition and evaluate the response of deck pavement under vehicle loads. An advantage of this model is that it can simulate not only the full-bond condition but also the debonding condition at somewhere between adjacent layers. The responses of the orthotropic steel deck pavement were calculated and analyzed by the model, and it found that this model is reasonable and credible to evaluate the responses of the deck pavement comparing with the previous researches. The full-bond condition was an ideal condition between adjacent layers, which was prone to underestimate the responses and deformation of the deck pavement. Moreover, the position and size of the disengaging area have a notable influence on the tensile strain at the top of SMA layer and the bottom of GA layer, and the tensile strain of them also increase with the increase of the disengaging area. Finally, the responses of the steel deck pavement changed obviously when the vehicle speed increase, so the suitable speed limit may reduce the responses and deformation for prolonging the service life of the orthotropic steel deck pavement.
The increased prevalence of keloids in atopic dermatitis patients with allergic comorbidities: a nationwide retrospective cohort study
Authors: Kwon Hyo-Eun , Ahn Hye-Jin , Jeong Su Jin , Shin Min Kyung 
Published: December 2021

AbstractAtopic dermatitis (AD) is associated with allergic comorbidities, such as asthma, allergic rhinitis (AR), and allergic contact dermatitis (ACD). The etiology of keloid is largely unknown; however, AD and keloid share inflammatory pathways characterized by T-helper cell 2 cytokines and increased dermal fibroblast activity. The prevalence of keloids has been reported to increase in patients with AD, but it remains controversial. This study aimed to estimate the prevalence of keloids in patients with AD, and compare it with the prevalence of other comorbidities of AD. We assessed the Korean National Health Information Database and medical records including coexisting asthma, AR, and ACD. Single and multiple logistic regression models were created for keloids and each allergic disease. The prevalence of keloids was higher in the AD group than in the control group. Among patients with AD, adolescents and adults had a higher prevalence of keloids than infants and children. The risk of keloids was high with AD alone, and coexisting asthma significantly increased the risk. Similarly, the risk of keloids was higher in AR associated with AD and ACD associated with AD than in AD alone. Thus, among Koreans, patients with AD have a higher risk of keloid development, with coexisting allergic diseases increasing the risk.
The effect of renin–angiotensin–aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19
Authors: Kim Gha-hyun J. , Melgoza Adam , Jiang Fei , Guo Su 
Published: December 2021

AbstractAmong cases of SARS-CoV-2 infections that result in serious conditions or death, many have pre-existing conditions such as hypertension and are on renin–angiotensin–aldosterone system (RAAS) inhibitors. The angiotensin-converting-enzyme-2 (ACE2), a key protein of the RAAS pathway, also mediates cellular entry of SARS-CoV-2. RAAS inhibitors might affect the expression levels of ace2, which could impact patient susceptibility to SARS-CoV-2. However, multi-organ-specific information is currently lacking and no species other than rodents have been examined. To address this knowledge gap, we treated adult zebrafish with the RAAS inhibitors aliskiren, olmesartan, and captopril for 7 consecutive days and performed qRT-PCR analysis of major RAAS pathway genes in the brain, gill, heart, intestine, kidney, and liver. Both olmesartan and captopril significantly increased ace2 expression in the heart, gill, and kidney. Olmesartan also increased ace2 expression in the intestine. Conversely, aliskiren significantly decreased ace2 expression in the heart. Discontinuation of compound treatments for 7 days did not return ace2 expression to baseline levels. While potential risks or benefits of antihypertensive RAAS inhibitors to SARS-CoV-2 infections in humans remain uncertain, this study provides new insights regarding the impact of RAAS inhibitors on organ-specific ace2 expression in another vertebrate model, thereby providing comparative data and laying scientific groundwork for future clinical decisions of RAAS inhibitor use in the context of COVID-19.
RYR2 mutation in non‐small cell lung cancer prolongs survival via down‐regulation of DKK1 and up‐regulation of GS1‐115G20.1: A weighted gene Co‐expression network analysis and risk prognostic models
Authors: Ren Wenjun , Li Yongwu , Chen Xi , Hu Sheng , Cheng Wanli , Cao Yu , Gao Jingcheng , Chen Xia , Xiong Da , Li Hongrong , Wang Ping 
Published: December 2021

AbstractRYR2 mutation is clinically frequent in non‐small cell lung cancer (NSCLC) with its function being elusive. We downloaded lung squamous cell carcinoma and lung adenocarcinoma samples from the TCGA database, split the samples into RYR2 mutant group (n = 337) and RYR2 wild group (n = 634), and established Kaplan‐Meier curves. The results showed that RYR2 mutant group lived longer than the wild group (p = 0.027). Weighted gene co‐expression network analysis (WGCNA) of differentially expressed genes (DEGs) yielded prognosis‐related genes. Five mRNAs and 10 lncRNAs were selected to build survival prognostic models with other clinical features. The AUCs of 2 models are 0.622 and 0.565 for predicting survival at 3 years. Among these genes, the AUCs of DKK1 and GS1‐115G20.1 expression levels were 0.607 and 0.560, respectively, which predicted the 3‐year survival rate of NSCLC sufferers. GSEA identified an association of high DKK1 expression with TP53, MTOR, and VEGF expression. Several target miRNAs interacting with GS1‐115G20.1 were observed to show the relationship with the phenotype, treatment, and survival of NSCLC. NSCLC patients with RYR2 mutation may obtain better prognosis by down‐regulating DKK1 and up‐regulating GS1‐115G20.1.
Ground-based HCN submillimetre measurements in Titan’s atmosphere: an intercomparison with Herschel observations
Authors: Rengel M. , Shulyak D. , Hartogh P. , Sagawa H. , Moreno R. , Jarchow C. , Breitschwerdt D. 
Published: December 2021

Aims. The aim of this study is to measure the vertical distribution of HCN on Titan’s stratosphere using ground-based submillimetre observations acquired quasi-simultaneously with the Herschel ones. This allows us to perform a consistency check between space and ground-based observations and to build a reference mean HCN vertical profile in Titan’s stratosphere.
Methods. Using APEX and IRAM 30-m, we obtained the spectral emission of HCN (4-3) and (3-2) lines. Observations were reduced with GILDAS-CLASS. We applied a line-by-line radiative transfer code to calculate the synthetic spectra of HCN, and a retrieval algorithm based on optimal estimation to retrieve the temperature and HCN vertical distributions. We used the standard deviation-based metric to quantify the dispersion between the ground-based and Herschel HCN profiles and the mean one.
Results. Our derived HCN abundance profiles are consistent with an increase from 40 ppb at ~100 km to 4 ppm at ~200 km, which is an altitude region where the HCN signatures are sensitive. We also demonstrate that the retrieved HCN distribution is sensitive to the data information and is restricted to Titan’s stratosphere. The HCN obtained from APEX data is less accurate than the one from IRAM data because of the poorer data quality, and covers a narrower altitude range. Comparisons between our results and the values from Herschel show similar abundance distributions, with maximum differences of 2.5 ppm ranging between 100 and 300 km in the vertical range. These comparisons also allow us to inter-validate both data sets and indicate reliable and consistent measurements. The inferred abundances are also consistent with the vertical distribution in previous observational studies, with the profiles from ALMA, Cassini/CIRS, and SMA (the latest ones below ~230 km). Our HCN profile is also comparable to photochemical models by Krasnopolsky (2014) and Vuitton et al. (2019) below 230 km and consistent with that of Loison et al. (2015) above 250 km. However, it appears to show large differences with respect to the estimates by Loison et al. (2015), Dobrijevic & Loison (2018), and Lora et al. (2018) below 170 km, and by Dobrijevic & Loison (2018) and Lora et al. (2018) above 400 km, although they are similar in shape. We conclude that these particular photochemical models need improvement.
L’exil est-il une solution pour les réfugiés politiques traumatisés ?
Authors: Birgul Cakir Cagda 
Published: December 2021

L’histoire collective, surtout lorsqu’elle est marquée par des conflits majeurs et de la violence, a un impact important sur l’histoire singulière. Le partage du trauma et sa réactivation sous certaines conditions, induisent des répercussions psychiques qui s’inscrivent dans la durée. Ces répercussions perdurent dans l’exil et se traduisent en difficultés d’intégration dans le pays d’accueil. L’objet de cet article est la présentation des données d’une recherche linéaire sur ce rapport entre mémoire collective et trajectoire individuelle. Nous présentons ici le vécu traumatique et les difficultés d’intégration de deux sujets turcs réfugiés politiques en France.
Nous nous sommes appuyés sur une démarche double : psychopathologique et catégorielle pour évaluer l’État de Stress Post Traumatique grâce aux critères diagnostiques du DSM-IV, puis psychanalytique et qualitative pour analyser d’un point de vue thématique les contenus des entretiens semi-directifs. Cette démarche retrace des trajectoires encore heurtées dans l’exil, du fait de difficultés d’adaptation. Par la symptomatologie qui réfère à leurs difficultés, à la suite à d’incarcérations et de torture, la trajectoire de ces sujets nous révèle une persistance de l’impact des traumatismes.
Fucoidan aus Braunalgen
Authors: Hees Bettina 
Published: December 2021

ZusammenfassungFucoidan ist ein Polysaccharid, das in Meeresbraunalgen, vor allem der Wakame-Alge, vorkommt. Es ist in vielen Ländern Asiens Bestandteil der täglichen Ernährung mit Algen, darüber hinaus wird es in der traditionellen asiatischen Medizin zur komplementären Behandlung von Tumorerkrankungen eingesetzt. Seit Kurzem ist Fucoidan auch in der EU als „Novel Food“-Lebensmittel bzw. Nahrungsergänzung zugelassen. Fucoidane besitzen eine Vielzahl an antikanzerogenen Wirkungen, was in vitro, in vivo und in klinischen Pilotstudien nachgewiesen werden konnte: Sie reduzieren proinflammatorische Prozesse, können die Proliferation von Krebszellen unterdrücken, aktivieren die Apoptose-Signale von Krebszellen und hemmen die Bildung von vaskulären Wachstumsfaktoren (VEGF), wodurch Angiogenese und Metastasierung unterdrückt werden können. Fucoidan besitzt sowohl systemische Wirkungen – erstmalig nachgewiesen mit Hilfe der microRNA Biomarker-Diagnostik – als auch lokale Wirkungen. Als Biological Response Modifier aktiviert und verbessert Fucoidan die Immunantwort im Darm als First-Line-Abwehr von Tumorzellen und Schlüsselfaktor der Tumorbekämpfung, es wirkt zusätzlich als Booster der natürlichen Killerzellaktivität. Fucoidan kann die Nebenwirkungen von Chemo- und Strahlentherapien reduzieren und es kann die therapeutischen Effekte konventioneller Tumortherapien verbessern. Der Beitrag stellt klinische Ergebnisse zu Fucoidan beim metastasierten Kolonkarzinom sowie bei Brustkrebs vor.
Editorial
Authors: Crismani Adriano 
Published: December 2021

Sehr geehrte Kolleginnen und Kollegen,ich darf Ihnen die vierte und letzte Ausgabe dieses Jahres präsentieren. Aktuelle und interessante Beiträge - von jungen und erfahrenen Autorinnen und Autoren aus Deutschland und Österreich verfasst, werden Sie mit Sicherheit finden. An dieser Stelle möchte ich mich sehr herzlich bei diesen für ihren Einsatz und ihre Professionalität bedanken!
Translatorische Zahnbewegung durch eine stark erweiterte Kieferhöhle
Authors: Wendl Brigitte , Pichelmayer Margit , Kirnbauer Barbara , Jakse Michael Payer Norbert 
Published: December 2021

ZusammenfassungDer kieferorthopädische Lückenschluss ist eine wichtige Alternative zur prothetischen Restauration mit Implantaten. Diese Zahnbewegung im Oberkiefer kann durch eine stark nach kaudal ausladende Kieferhöhle mit steil ansteigendem vertikalem Kieferhöhlenboden und weit in den Sinus reichende Zahnwurzeln erschwert werden. Die vorgestellten Fallberichte 2 und 3 zeigen eine Methode zur Erleichterung eines translatorischen Lückenschlusses durch die Kieferhöhle mithilfe eines interdisziplinären chirurgischen Ansatzes (Sinuslift mit Augmentation) bei sehr tief reichendem Sinus maxillaris.Die radiologische und klinische Bewertung dieser beiden kieferorthopädischen Fälle zeigte eine erfolgreiche translatorische kieferorthopädische Zahnbewegung durch eine stark vergrößerte Kieferhöhle, die durch Knochenaugmentation unter Verwendung eines synthetischen Knochenersatzmaterials unterstützt wurde. Es gab keine signifikanten Anzeichen einer Wurzelresorption.
OCT-Angiografie als interdisziplinäres Diagnostikum für Systemerkrankungen
Authors: Hohberger Bettina , Mardin Christian Yahya 
Published: December 2021

ZusammenfassungDie OCT-Angiografie (OCT-A) hat sich zu einer festen Bildgebungsmethode der Retina entwickelt. Sie ermöglicht eine nichtinvasive Darstellung der Mikrozirkulation im Mikrometerbereich bei ophthalmologischen Pathologien sowie bei Systemerkrankungen mit möglicher okulärer Beteiligung. Das Review fasst den aktuellen Stand hierzu zusammen.
Revisiting the Death and Autopsy of King George II
Authors: Suzuki Yota , DeAnda Abe 
Published: December 2021

AbstractIt is commonly accepted that King George II died of an acute aortic dissection. The origin of this association derives from retelling of the official autopsy performed by Dr. Frank Nicholls. While there is no doubt that King George II did have a Stanford Type A dissection, critical descriptions in the report point to a more likely cause of death.
Using an Endovascular Strategy in the Open Setting: The Challenges of Hybrid Repair Using Frozen Elephant Trunk in an Extensively Dilated Aorta Associated with Coarctation
Authors: Harrington Bertram , McPherson Iain , Bayliss Christopher , Barnard Sion , McCaslin James , Williams Robin , Booth Karen 
Published: December 2021

AbstractWith both stenosis and aneurysm, repairing a severely tortuous and coarcted aorta can present certain difficulties. The advent of hybrid arch frozen elephant trunk techniques, as well as other endovascular solutions, has produced safer surgical repair methods for such cases. We present the reconstruction and repair of a Type-1 thoracoabdominal aortic aneurysm using a staged approach in less-than-optimal anatomy. Interventions included hybrid frozen elephant trunk, balloon dilation, and thoracic endovascular repair.
Development and Implementation of an e-Learning Program on Glasgow Coma Scale
Authors: Xavier Teenu , Kuriakose Merin Lisa , Robin Metilda , Agrawal Deepak 
Published: December 2021

Abstract
Background With the advancement in technology, e-learning is an attractive platform to facilitate online continuing medical education. The aim of the study was to develop a web-based nursing education program on the Glasgow coma scale (GCS) and to assess the effectiveness of this module in improving the knowledge of nurses.
Methods A one-group pretest posttest study was conducted among nurses working in a tertiary care hospital in New Delhi, India, from November 2015 till July 2016. Before administering the GCS module, an online questionnaire was used to assess the baseline knowledge. After the completion of the module, a posttest questionnaire was administered and assessed.
Results A total of 3500 users completed the e-learning GCS module. The mean pretest score was 4.2 ± 2.1, and the mean posttest score was 7.3 ± 2.5. The mean difference in the score was statistically highly significant (p < 0.05).
Conclusion The e-learning module is an effective means of providing continuing online education to the nurses, so that they can update their knowledge.