bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Anterior Cervical Discectomy and Fusion (ACDF) Through Mini-Incision and Posterior Laminoplasty (LAMP) For Treatment of Long-Level Cervical Spondylosis
Authors: Zhang Yingkai , Yang Guangling , Zhou Tianyao , Chen Yanchao , Gao Zhenchao , Zhou Weili , Gu Yutong 
Published: December 2021

Abstract
Background: The efficacy and safety of anterior cervical discectomy and fusion (ACDF) through mini-incision and posterior laminoplasty for long-level cervical spondylosis were investigated. Method: From January 2018 to September 2019, clinical patients data with 3-4 segments (C3-7) cervical spondylotic radiculopathy, cervical spondylotic myelopathy, or mixed cervical spondylosis who received ACDF (42 cases) throughwith mini-incision or LAMP (36 cases) treatment were retrospectively collected and analyzed. The operative time, bleeding volume, incisive length, and hospital stay were recorded. Moreover, the intervertebral height, functional segment height, cervical lordosis, cervical hyperextension and hyperflexion range-of-motion (ROM) and ROM in all directions of the cervical spine before and after the operation were measured. Additionally, all relevant postoperative complications were also recorded. Then, the therapeutic effects of both surgical methods were investigated.Results: Patients in the ACDF group had less bleeding, shorter incision, and fewer hospitalization days than the LAMP group. Postoperative intervertebral height and functional segment height in the ACDF group were significantly higher than those before the operation, and postoperative functional segment height of the ACDF group was significantly higher than that of the LAMP group. Moreover, the postoperative cervical lordosis angle in the ACDF group was significantly larger than the LAMP group. There was no significant difference between preoperative and postoperative ROM in all directions of the cervical spine for the two groups.Conclusions: Both ACDF through mini-incision and LAMP are effective treatments for long-level cervical spondylosis. However, ACDF through mini-incision shows minor trauma, less bleeding, fast recovery, and it is beneficial for cervical lordosis reconstruction.
Parachute structure trisiloxane surfactant: synthesis and its use in reverse flotation of iron ore
Authors: Huang Zhiqiang , Zhang Shiyong , Burov Vladimir E. , Wang Hongling , Liu Rukuan , Cheng Chen , Shuai Shuyi , Li Wenyuan , Yu Xinyang , He Guichun , Fu Weng , Poilov Vladimir Z. 
Published: December 2021

Abstract
No single element has exerted such a deep influence on social organization of mankind as iron. Magnetite is concentrated by froth flotation and used as a raw material to produce iron. However, the conventional surfactants used in the flotation process often lead to the weak collecting performance due to their analogous alkyl hydrophobic group. Here, we report a new trisiloxane surfactant N-(β-aminoethyl)-γ-aminopropyltrisiloxane (AAT) in magnetite flotation, which was compared with the traditional collector dodecylamine (DA). The flotation test results showed that AAT had excellent collecting ability and selectivity for quartz against magnetite. Magnetite concentrate with TFe recovery of 84.79%, TFe grade of 68.84% and SiO2 grade of 6.15% was obtained by using 150 g/t AAT. Density functional theory calculations suggested reactive site of AAT was cationic –CH2N+H3 group, and AAT showed a higher positive grouping Mulliken charge and chemical reactivity that may promote its flotation performance.
Characteristics and Nomogram for Primary Lung Lepidic Adenocarcinoma
Authors: Tang Hui , Wang Yingyi , Bai Chunmei 
Published: December 2021

Abstract
Background: Lepidic adenocarcinoma (LPA) is an infrequent subtype of invasive pulmonary adenocarcinoma (ADC). However, the clinicopathological features and prognostic factors of LPA have not been elucidated.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database of 4087 LPA patients were retrospectively analyzed and compared with non-LPA pulmonary ADC to explore the clinicopathological and prognosis features of LPA. Univariate and multivariate Cox proportional hazard models were performed to identify independent survival predictors for further nomogram development. The nomograms were validated by using the concordance index, receiver operating characteristic curves, and calibration plots, as well as decision curve analysis, in both the training and validation cohorts.Results: Compared with non-LPA pulmonary ADC patients, those with LPA exhibited unique clinicopathological features, including more elderly and female patients, smaller tumor size, less pleural invasion, and lower histological grade and stage. Multivariate analyses showed that age, sex, marital status, primary tumor size, pleural invasion, histological grade, stage, primary tumor surgery, and chemotherapy were independently associated with overall survival (OS) and cancer-specific survival (CSS) in patients with LPA, while race was the only independent prognostic factor for OS, not for CSS. The nomograms showed good accuracy compared with the actual observed results and demonstrated improved prognostic capacity compared with TNM stage.Conclusions: Patients with LPA are more likely to be older and female. Smaller tumor size, lower histological grade and stage are the clinicopathological features of LPA, which may indicate a good prognosis. The constructed nomograms accurately predict the long-term survival of LPA patients.
Biochemical and biophysical changes in plasma and erythrocyte membranes of alcohol consuming type 2 diabetics: A clinical study
Authors: Naresh Ellutla , Hebbani Ananda Vardhan , Reddy Vaddi Damodara , NCh Varadacharyulu 
Published: December 2021

Abstract
Background and aims:

Effects of alcohol consumption on blood glucose levels is unpredictable and more so with a known type 2 diabetic. Since type 2 diabetes is a chronic condition with impairment of glucose metabolism, influence of excess alcohol consumption in such a derailed metabolism is ought to be investigated. Our aim was to understand the interpolating relationship between the metabolisms of glucose and alcohol, by investigating the biochemical and biophysical changes in plasma and erythrocytes respectively.
Methods

We performed a clinical study with 20 human subjects wherein non-alcoholics, non-diabetics were considered as controls and the test subjects were categorized as alcoholics, diabetics and alcoholic diabetics. Findings were analysed against the control group.
Results

Increased plasma AST, ALT, ALP, and LDH enzyme activity; higher levels of nitric oxide, thiobarbituric acid reactive species (TBARS) both in plasma and erythrocyte lysate; higher fasting and postprandial glucose, glycated haemoglobin levels (Hb1Ac) levels; elevated levels of erythrocyte membrane total cholesterol / phospholipids (C/P) ratio and altered erythrocyte membrane fluidity in the alcoholic diabetics was noted.
Conclusion

Alcohol induced oxidative and nitrosative stress during its metabolism and its worsening effects in type II diabetics leading to a failure in the overall metabolic homeostasis is evident from the study.
Synergetic Potential of Green Synthesized Nano-Antibiotic Combinational Therapy For Wound Healing
Authors: Kalyani R.L. , Kumar K.T. Sunil , Swamy P.V. , Sekhar K. Chandra , Manish S. , Murthy K.V. Ramana , S.V.N.Pammi  
Published: December 2021

Abstract
The increasing evidences of chronic surgical wounds and its associated complications in association with bacterial resistance to conventional antibiotics. Therefore, current antibiotic resistance crisis ultimately calls for the need of alternative antibacterial options and nanotechnology could be a solution. Furthermore, nano-antibiotics combinations will provide synergy with reducing the dosage of both agents, which can enhance biocompatibility and may aid in limiting the global crisis of emerging multidrug resistance. Specifically, in the context of cytotoxicity of nanoparticles, in the present study, green synthesized nanoparticles (Ag NPs, ZnO NPs) are used for the combination with antibiotic neomycin to investigate in-vivo wound healing activity to facilitate the tissue repair with minimized toxicity. Our results showed that, in-vivo potent synergetic wound healing effectiveness and faster wound contraction of prepared gel formulations from the green synthesized nanoparticles combinations with neomycin compared with neomycin or nanoparticles alone. These results point to the opportunity provided by this approach to realize the unmet needs and future directions with lustrous prospects in combinational herbal nanomedicine to combat the multi drug resistant bacteria.
Dopamine Use and Its Consequences in The Intensive Care Unit: a Cohort Study Utilizing the Japanese Intensive care Patient Database
Authors: Suzuki Reina , Uchino Shigehiko , Sasabuchi Yusuke , Lefor Alan Kawarai , Sanui Masamitsu 
Published: December 2021

Abstract
Background: Dopamine is used to treat patients with shock in intensive care units (ICU) throughout the world, despite recent evidence against its use. Current practice patterns for the use of dopamine have not been reported.Methods: The Japanese Intensive Care PAtient Database (JIPAD), the largest intensive care database in Japan, was utilized. Inclusion criteria included: 1) age 18 years or older, 2) admitted to the ICU for reasons other than procedures, 3) ICU length of stay of 24 hours or more, and 4) treatment with either dopamine or noradrenaline within 24 hours of admission. The primary outcome was in-hospital mortality. Multivariable regression analysis was performed, followed by a pre-planned propensity score-matched analysis.Results: Of the 132,354 case records, 14594 records from 56 facilities were included in this analysis. Dopamine was administered to 4653 patients and noradrenaline to 11844. There was no statistically significant difference in facility characteristics between frequent dopamine users (N = 28) and infrequent users (N = 28). Patients receiving dopamine had more cardiovascular diagnosis codes (70% vs. 42%; p<0.01), more post-elective surgery status (60% vs. 31%), and lower APACHE III scores compared to patients given noradrenaline alone (70.7 vs. 83.0; p<0.01). Multivariable analysis showed an odds ratio for in-hospital mortality of 0.86 [95% CI: 0.71-1.04] in the dopamine <=5 μg/kg/min group, 1.50 [95% CI: 1.18-1.82] in the 5-15 μg/kg/min group, and 3.30 [95% CI: 1.19-9.20] in the >15 μg/kg/min group. In 1:1 propensity score matching for dopamine use (3322 pairs), there was no statistically significant difference for in-hospital mortality between the dopamine group and no dopamine group (13.0% vs. 12.0%, p=0.21), but ICU length of stay was significantly longer in the dopamine group (mean 7.4 days vs. 6.6 days, p<0.01).Conclusion: Dopamine is still widely used in Japan. The results of this study suggest detrimental effects of dopamine use specifically at a high dose, although there is no significant association with increased in-hospital mortality.Trial registration: Retrospectively registered upon approval of the Institutional Review Board and the administration office of JIPAD.
Non-Invasive Prenatal Detecting of Achondroplasia In Earlier Stage of Pregnancy By Droplet-Digital PCR
Authors: Wang Yipeng , Wang Wei , Wang Chengrong , Li Shanshan , Zhang Meng , Yin Chenghong 
Published: December 2021

Abstract
Background: Achondroplasia (ACH) is generally detected by abnormal prenatal ultrasound findings in the late stage of pregnancy and then confirmed by molecular genetic testing of fetal genomic DNA obtained invasively. Most ACH cases appear to be de novo mutations with FGFR3 gene, so it is a challenge to screen ACH fetus out in the early stage of pregnancy.Objective: The aim of this study was to validate the possibility of detect fetus ACH along with non-invasive prenatal screening(NIPS) routinely in the early stage of pregnancy.Methods: 5927 cases of pregnant women undergoing NIPS were enrolled in this study. An additional 5ml of blood was collected together with NIPS blood sampling. Cell free DNA was extracted for the detecting of fetus ACH. Droplet-digital PCR(ddPCR) method based on the amplification of the two possible mutant alleles (c. 1138G>A and c. 1138G>C) of FGFR3 gene was performed to screen fetus ACH. Prenatal ultrasound and amniocentesis were then performed to confirm the positive screening result of ACH cases. The mutation sites of fetus were identified via Sanger sequencing by using amniotic fluid cells. For the screen negative cases of pregnant women, we followed up the results of prenatal diagnosis or the general conditions of the newborns.Results: One pregnant woman with fetus ACH were screened out at 22 weeks by Non-invasive prenatal detecting. Later prenatal ultrasound confirmed fetal skeletal dysplasia. Sanger sequencing confirmed de novo FGFR3 1138G>A mutant of the fetus. No ACH fetus or newborns were found in the rest detected negative cases of enrolled pregnant women.Conclusion: ddPCR technology could effectively identify de novo mutation like ACH of fetus noninvasively. We prospect the clinical application of ddPCR can expand the range of prenatal screen in the future.
Association Between Blood Pressure And Lung Function In Chinese Children: The Seven Northeastern Cities Study
Authors: Huo Da , Yang Mo , Wu Qi-Zhen , Lodge Caroline J , Perret Jennifer L , Bui Dinh S , Dharmage Shyamali C , Jalava Pasi , Hu Qiang , Dong Guang-Hui 
Published: December 2021

Abstract
Background: A global increase in asthma and COPD incidence has occurred, the cause is unknown. One potential relationship that has yet to be explored is the interaction between blood pressure (BP) and lung function in children 5-17 years old. Our purpose is to assess the relationship between hypotension, hypertension, and lung function in children 5 to 17 years old. Methods: Participants were recruited from elementary and middle schools from 7 cities in northeastern China (N=6,797). BP was categorized into 3 groups: hypotensive (<5th percentile or <90mmHg if children >10 years), normotensive and hypertensive (>95th percentile) based on American Academy of Pediatrics standards. Spirometry measured lung function in forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and maximum mid expiratory flow (MMEF). Associations were assessed using logistic regression analysis. Results: Decreases in FVC , FEV1, PEF, and MMEF were noted in hypotensive children. Higher FVC, FEV1, PEF, and MMEF were noted among children ³ 10 with hypertension, while children <10 years, only had increased FVC compared to normotensive children. Statistically significant interactions between hypotension and PEF < 75% (OR:2.31; 95% CI: 1.17-4.23), were seen for children < 10 years. Conclusions: Our findings suggest that, in this study population, hypotension may be associated with decreased lung function, and the increased lung function may be associated with hypertension in children. Future studies are needed to confirm temporality as this is the first study to explore these relationships in children which requires in depth investigation.
Dynamical systems implementation of intrinsic sentence meaning
Authors: Moisl Hermann 
Published: December 2021

Abstract
This paper proposes a model for implementation of intrinsic natural language sentence meaning in a physical language understanding system, where 'intrinsic' is understood as 'independent of meaning ascription by system-external observers'. The proposal is that intrinsic meaning can be implemented as a point attractor in the state space of a nonlinear dynamical system with feedback which is generated by temporally sequenced inputs. It is motivated by John Searle's well known (1980) critique of the then-standard and currently still influential Computational Theory of Mind (CTM), the essence of which was that CTM representations lack intrinsic meaning because that meaning is dependent on ascription by an observer. The proposed dynamical model comprises a collection of interacting artificial neural networks, and constitutes a radical simplification of the principle of compositional phrase structure which is at the heart of the current standard view of sentence semantics because it is computationally interpretable as a finite state machine.
Exact solutions of sixth and fifth degree equations
Authors: MONIR Mohammed El Amine 
Published: December 2021

Abstract
The real problematic with algebraic polynomial equations is how to exactly solve any sixth and fifth degree polynomial equations. In this study, we give a new absolute method that presents a new decomposition to exactly solve a sixth degree polynomial equation, while the corresponding fifth degree equation can be easily transformed into a sixth degree equation of this kind (sixth degree equation solvable by this method), then the sextic equation (sixth degree equation) obtained will be solved by applying the principles of this method; moreover, the solutions of the quintic equation (fifth degree equation) will be easily deduced.
A model for determining the time of pointing a grip-cutting device of feller buncher machines on a growing tree
Authors: Андронов А.В. , Зверев И.А. , Михайлов О.А. , Тарадин Г.С. 
Published: December 2021

Исследование посвящено нахождению аналитической математической модели по определению времени наведения захватно-срезающего устройства на растущее дерево. В качестве известных параметров используются конструктивные размеры технологического оборудования, снятые с компоновочно-кинематических схем валочно-пакетирующих машин, требуемая высота пня и среднее расстояние между деревьями пасики. Поиск требуемой модели кратко можно разделить на несколько последовательных этапов: нахождение пути, который пройдет шток гидроцилиндра привода стрелы, и по известной формуле скорости перемещения поршня гидроцилиндра находится время на подвод стрелы к дереву; нахождение пути, который пройдет шток гидроцилиндра привода рукояти; нахождение пути, который пройдет шток гидроцилиндра привода наклона захватно-срезающего устройства; нахождение пути, который пройдет шток гидроцилиндра привода рычагов захвата в процессе раскрытия. Сумма времени на подвод каждого из элементов технологического оборудования и есть время на наведение, присущее неопытному оператору, в случае опытного оператора время на наведение захватно-срезающего устройства к дереву определяется максимальным временем одного из компонентов.
The research is devoted to finding an analytical mathematical model for determining the aiming time of a feller head on a growing tree. As the known parameters are used. The design dimensions of the technological equipment, taken from layout and kinematic diagrams of feller-buncher machines, the required stump height and the average distance between the trees of the windrow. The search for the required model can be briefly divided into several successive steps: finding the path that the hydraulic cylinder rod of the boom drive will take and by the known formula of speed of movement of the hydraulic cylinder piston is time to bring the boom to the tree; finding the way which the rod of the hydraulic cylinder of the arm drive; to find the path which the hydraulic cylinder rod of the tilt of the feller head; finding the path which the hydraulic cylinder rod for the arm actuator will take during the opening. The sum of the time for supplying each of the elements of technological equipment is the time required for the orientation, which is characteristic for a nonexperienced operator. In case of an experienced operator the time for setting the feller head to the tree is determined by the maximum time of one of the components.
Pour point depressants for fuels based on tall oil fatty acid esters
Authors: Курзин А.В. , Евдокимов А.Н. 
Published: December 2021

С целью расширения области применения жирных кислот таллового масла – побочного продукта сульфатной варки целлюлозы (которые преимущественно состоят из непредельных С18-кислот), в том числе за счет получения различных синтетических продуктов на их основе, синтезированы соответствующие этиленгликолевый и додециловый эфиры. Изучена возможность применения указанных сложных эфиров в качестве депрессорных присадок для марок универсального топливного мазута и судового экологического топлива. Жирные кислоты этерифицированы 1-додеканолом и этиленгликолем в присутствии катализатора п-толуолсульфокислоты. Температуру текучести топлив определяли ручным методом по стандарту ASTM D97. Температура текучести топлива судового экологического снизилась с +21 до 0 °С при использовании 2% додецилового эфира жирных кислот в качестве присадки. Установлено, что синтезированные эфиры жирных кислот таллового масла снижают температуру текучести остаточных топлив на уровне, сравнимом с применением промышленно производимой депрессорной присадки, что позволяет расширить сырьевую базу присадок этого типа и сократить закупки по импорту, а также более глубоко использовать жирные кислоты таллового масла в органическом синтезе.
In order to expand the field of application of tall oil fatty acids, a by-product of sulfate pulping (which mainly consist of unsaturated C18 acids), including the production of various synthetic products based on them, the corresponding ethylene glycol and dodecyl esters have been synthesized. The possibility of application the esters as pour point depressants for grades of universal fuel oil and marine ecological fuel has been studied. Fatty acids were esterified with 1-dodecanol and ethylene glycol in the presence of a p-toluenesulfonic acid as catalyst. The pour point of the fuels was determined manually according to the ASTM D97 standard. The pour point of ecological marine fuel decreased from +21 to 0 °C when using 2% dodecyl ester of fatty acids as an additive. It was found that the synthesized esters of tall oil fatty acids reduce the pour point of residual fuels at a level comparable to the use of a commercially produced depressant additive, which makes it possible to expand the feedstock base of this type of additives and reduce import purchases, as well as to use more extensively tall oil fatty acids in organic synthesis.
Design characteristics of showering aeration system
Authors: Roshan R. U. , Mohammad Tanveer , Roy Subha M. , Rajendran R. 
Published: December 2021

AbstractThe showering aeration system (SAS) was designed and its performance was evaluated by conducting the aeration experiments in a tank of dimension 2 × 4 × 1.5 m. Initially, the aeration experiments were conducted to optimize the radius of curvature of the SAS with different values, such as = 0, 5, 10, 15, and 20 mm, and maintain other geometric parameters, i.e. number of holes in the shower (); height of water fall (H); diameter of the shower hole (d); volume of water under aeration (V) and water flow rate (Q) as constants. The optimum radius of curvature () was found to be 10 mm. The aeration experiments were further conducted with four different non-dimensional geometric parameters such as the number of holes , the ratio of the height of water fall to the length of shower arm the ratio of the diameter of the hole to the length of shower arm and the ratio of the volume of water to the cube of the length of shower arm The Response Surface Methodology and Box–Behnken Design were used to optimize the non-dimensional geometric parameters of the SAS to maximize the Non-Dimensional Standard Aeration Efficiency. The result indicates that the maximum NDSAE of 16.98 × 106 was obtained from the SAS performance at = 80; = 2; = 4 and = 48.