bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping with Covid-19: Forging Creative Pathways to Support Educational Continuity Amidst the Pandemic
Authors: Yeravdekar Vidya , Kapur Nidhi Piplani 
Published: October 2021

AbstractThe pandemic has forced all educational institutions to grapple with challenges. Throughout this time Symbiosis International University (SIU) in India has been proactive in leading change not only at the university but also in K-12 schools. While the university transitioned to virtual teaching and learning, a methodical approach was laid out in assisting its eight elementary and senior secondary schools in both urban and rural areas, through the Symbiosis Schools Central Directorate (SSCD), to adapt to the needs of a public health crisis. While connectivity challenges continue to haunt schools, especially in rural areas, training and capacity building of K-12 teachers and administrators by university professors and experts has been a saving grace in navigating the pandemic.The focus of this case is understanding the parallels and the partnership between SIU and its K-12 schools. It reflects a bottom-up approach in dealing with the pandemic where Symbiosis Society, the non-profit organization that has established the schools as well as the University, invested in teacher capacity building at its elementary and secondary schools through its Symbiosis Schools Central Directorate (SSCD) in both rural and urban areas to ensure continuity of teaching and learning while adapting to this new normal. The investment in teacher capacity building has enabled the leadership to address the emerging circumstances, stimulate momentum to create or demand needed change at their institutions, inspire peer learning, and foster innovation in strategy and practice for the greater benefit of its stakeholders including students and parents.This case study reflects on SIU experiences in dealing with the dynamic circumstances such as training and capacity building with respect to supporting teachers in developing skills to adapt their content to virtual mode, blended learning, and integrating Collaborative Online International Learning (COIL) into the curriculum. In addition, SIU had to counsel students and parents to adapt to this new way of learning. SIU’s experience encompasses a coordinated approach of working with internal and external stakeholders to develop a response to the crisis, short-to-medium-term strategic planning in the face of uncertainty, exploring technology solutions, partnership management, and effective communication processes with its stakeholders. Special emphasis has been put on ensuring the mental and physical wellbeing of the learner, constant communication and guidance to parents, and virtual activities to promote community engagement to mitigate the loss of physical social interactions at this crucial time.
Design and Evaluation of a Serious Game to Supplement Pupils’ Understanding of Molecular Structures in Chemistry
Authors: Bjørner Thomas , Hansen Louise Gaard , Valimaa Miicha , Sørensen Julie Ulnits , Dobre Mircea 
Published: October 2021

AbstractThis study is initial experiences in the design and evaluation of a serious game to supplement pupils’ understanding of molecular structures in chemistry. 27 pupils were included in the study, aged 13–14, with 16 boys and 11 girls. All participants were recruited from two chemistry classes at a Danish elementary school in Copenhagen. A formative evaluation consisted of both a questionnaire, observations, and interviews. The questionnaire was inspired by the User Engagement Scale (UES) short-form. Designing a serious game for pupils with the aim to increase the understanding of molecular structures, is not an easy task. This serious game was to some extend able to engage the pupils within the subject of chemistry. The game itself was reported to be very engaging, but the specific learning outcomes remains uncertain. We can conclude that the serious game was visually appealing, the pupils were absorbed in the game, and wanted to continue playing. However, the designed serious game was also a bit confusing and made too difficult, resulting in frustrations for the pupils. Further, there are still some important challenges in how to increase the validity and reliability when evaluating serious games with children and adolescent as the users.
Die Forschungsgruppe Ethisch-Ökologisches Rating (FG EÖR) am Fachbereich Katholische Theologie der Goethe-Universität Frankfurt
Authors: Hoffmann Johannes J. 
Published: October 2021

ZusammenfassungDer Beitrag informiert über die Arbeit der Forschungsgruppe Ethisch-Ökologisches Rating der Goethe-Universität in Frankfurt. Die Gruppe war interdisziplinär, interkulturell, ökumenisch und transdisziplinär zusammengesetzt. Sie hat als erste bereits in den 90-er Jahren anhand einer Wertbaumanalyse eine wissenschaftlich gestützte Kriteriologie zur Bewertung von Kapitalanlagen, den sogenannten Frankfurt-Hohenheim Leitfaden (FHL) entwickelt. Der FHL wurde gemeinsam mit einer Ratingagentur, nämlich der oekom research GmbH in München, in ein Ratingkonzept übertragen, nämlich das Corporate Responsibility Rating (CRR). Der Beitrag informiert über die Entwicklung, Anwendung, Grenzen und die mögliche Weiterentwicklung des Konzeptes. Inzwischen wird das CRR weltweit umgesetzt.
Der Mensch und der Rhein
Authors: Streit Bruno 
Published: October 2021

ZusammenfassungDer Rhein und seine Zuflüsse zeigen eine wechselvolle hydrologische, biologische und kulturelle Geschichte. Menschen leben seit mindestens 600.000 Jahren am Flusssystem. Das Kapitel beleuchtet ihre wechselvolle Beziehung zum Rhein, der für sie Barriere, Grenze oder Verteidigungslinie, Nahrungslieferant, Waren- und Personentransportweg, Vorfluter für Abwässer, Energiequelle oder eine Region für Freizeittourismus war. Wechselnde gesellschaftliche Ziele haben Sichtweisen und Nachhaltigkeitskonzepte für Fluss und Landschaft geprägt und immer wieder modifiziert.
String excitation by initial singularity of inflation
Authors: Nishii Kanji , Yoshida Daisuke 
Published: October 2021

Abstract
We discuss excitation of string oscillation modes by an initial singularity of inflation. The initial singularity of inflation is known to occur with a finite Hubble parameter, which is generally lower than the string scale, and hence it is not clear that stringy effects become significant around it. With the help of Penrose limit, we find that infinitely heavy oscillation modes get excited when a singularity is strong in the sense of Krolak’s classification. We demonstrate that the initial singularities of Starobinsky and hill top inflation, assuming the slow roll inflation to the past infinity, are strong. Hence stringy corrections are inevitable in the very early stage of these inflation models. We also find that the initial singularity of the hill top inflation could be weak for non-slow roll case.
Mean Field Derivation of DNLS from the Bose–Hubbard Model
Authors: Picari E. , Ponno A. , Zanelli L. 
Published: October 2021

AbstractWe prove that the flow of the discrete nonlinear Schrödinger equation (DNLS) is the mean field limit of the quantum dynamics of the Bose–Hubbard model for N interacting particles. In particular, we show that the Wick symbol of the annihilation operators evolved in the Heisenberg picture converges, as N becomes large, to the solution of the DNLS. A quantitative $$L^p$$

L
p

-estimate, for any $$p \ge 1$$

p
≥
1

, is obtained with a linear dependence on time due to a Gaussian measure on initial data coherent states.
Internal fixation versus hip arthroplasty in patients with nondisplaced femoral neck fractures: short-term results from a geriatric trauma registry
Authors: Laubach Markus , Bläsius Felix M. , Volland Ruth , Knobe Matthias , Weber Christian D. , Hildebrand Frank , Pishnamaz Miguel ,   Registry for Geriatric Trauma DGU, Knobe Matthias 
Published: October 2021

Abstract
Purpose
To determine whether internal fixation (IF) or hip arthroplasty (HA) is associated with superior outcomes in geriatric nondisplaced femoral neck fracture (FNF) patients.

Methods
Data from the Registry for Geriatric Trauma of the German Trauma Society (ATR-DGU) were analyzed (IF Group 449 and HA Group 1278 patients). In-hospital care and a 120-day postoperative follow-up were conducted. Primary outcomes, including mobility, residential status, reoperation rate, and a generic health status measure (EQ-5D score), and the secondary outcome of mortality were compared between groups. Multivariable analyses were performed to assess independent treatment group associations (odds ratios, ORs) with the primary and secondary end points.

Results
Patients in the HA group were older (83 vs. 81 years, p < 0.001) and scored higher on the Identification of Seniors at Risk screening (3 vs. 2, p < 0.001). We observed no differences in residential status, reoperation rate, EQ-5D score, or mortality between groups. After adjusting for key covariates, including prefracture ambulatory capacity, the mobility of patients in the HA group was more frequently impaired at the 120-day follow-up (OR 2.28, 95% confidence interval = 1.11–4.74).

Conclusion
Treatment with HA compared to treatment with IF led to a more than twofold increase in the adjusted odds of impaired ambulation at the short-term follow-up, while no significant associations with residential status, reoperation rate, EQ-5D index score, or mortality were observed. Thus, IF for geriatric nondisplaced FNFs was associated with superior mobility 120 days after surgery. However, before definitive treatment recommendations can be made, prospective, randomized, long-term studies must be performed to confirm our findings.
Ledrappier–Young formulae for a family of nonlinear attractors
Authors: Jurga Natalia , Lee Lawrence D. 
Published: October 2021

AbstractWe study a natural class of invariant measures supported on the attractors of a family of nonlinear, non-conformal iterated function systems introduced by Falconer, Fraser and Lee. These are pushforward quasi-Bernoulli measures, a class which includes the well-known class of Gibbs measures for Hölder continuous potentials. We show that these measures are exact dimensional and that their exact dimensions satisfy a Ledrappier–Young formula.
Repeatability and reproducibility of deep-learning-based liver volume and Couinaud segment volume measurement tool
Authors: Mojtahed Amirkasra , Núñez Luis , Connell John , Fichera Alessandro , Nicholls Rowan , Barone Angela , Marieiro Mariana , Puddu Anthony , Arya Zobair , Ferreira Carlos , Ridgway Ged , Kelly Matt , Lamb Hildo J. , Caseiro-Alves Felipe , Brady J. Michael , Banerjee Rajarshi 
Published: October 2021

Abstract
Purpose
Volumetric and health assessment of the liver is crucial to avoid poor post-operative outcomes following liver resection surgery. No current methods allow for concurrent and accurate measurement of both Couinaud segmental volumes for future liver remnant estimation and liver health using non-invasive imaging. In this study, we demonstrate the accuracy and precision of segmental volume measurements using new medical software, Hepatica™.

Methods
MRI scans from 48 volunteers from three previous studies were used in this analysis. Measurements obtained from Hepatica™ were compared with OsiriX. Time required per case with each software was also compared. The performance of technicians and experienced radiologists as well as the repeatability and reproducibility were compared using Bland–Altman plots and limits of agreement.

Results
High levels of agreement and lower inter-operator variability for liver volume measurements were shown between Hepatica™ and existing methods for liver volumetry (mean Dice score 0.947 ± 0.010). A high consistency between technicians and experienced radiologists using the device for volumetry was shown (± 3.5% of total liver volume) as well as low inter-observer and intra-observer variability. Tight limits of agreement were shown between repeated Couinaud segment volume (+ 3.4% of whole liver), segmental liver fibroinflammation and segmental liver fat measurements in the same participant on the same scanner and between different scanners. An underestimation of whole-liver volume was observed between three non-reference scanners.

Conclusion
Hepatica™ produces accurate and precise whole-liver and Couinaud segment volume and liver tissue characteristic measurements. Measurements are consistent between trained technicians and experienced radiologists.

Graphic abstract
The German Guidelines for the treatment of anxiety disorders: first revision
Authors: Bandelow Borwin , Werner Antonia M. , Kopp Ina , Rudolf Sebastian , Wiltink Jörg , Beutel Manfred E. 
Published: October 2021

AbstractStarting in 2019, the 2014 German Guidelines for Anxiety Disorders (Bandelow et al. Eur Arch Psychiatry Clin Neurosci 265:363–373, 2015) have been revised by a consensus group consisting of 35 experts representing the 29 leading German specialist societies and patient self-help organizations. While the first version of the guideline was based on 403 randomized controlled studies (RCTs), 92 additional RCTs have been included in this revision. According to the consensus committee, anxiety disorders should be treated with psychotherapy, pharmacological drugs, or their combination. Cognitive behavioral therapy (CBT) was regarded as the psychological treatment with the highest level of evidence. Psychodynamic therapy (PDT) was recommended when CBT was not effective or unavailable or when PDT was preferred by the patient informed about more effective alternatives. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs) are recommended as first-line drugs for anxiety disorders. Medications should be continued for 6–12 months after remission. When either medications or psychotherapy were not effective, treatment should be switched to the other approach or to their combination. For patients non-responsive to standard treatments, a number of alternative strategies have been suggested. An individual treatment plan should consider efficacy, side effects, costs and the preference of the patient. Changes in the revision include recommendations regarding virtual reality exposure therapy, Internet interventions and systemic therapy. The recommendations are not only applicable for Germany but may also be helpful for developing treatment plans in all other countries.
Outcome of patients with relapsed or refractory acute myeloid leukemia treated with Mito-FLAG salvage chemotherapy
Authors: Mühleck Regina , Scholl Sebastian , Hilgendorf Inken , Schrenk Karin , Hammersen Jakob , Frietsch Jochen J. , Fleischmann Maximilian , Sayer Herbert G. , Glaser Anita , Hochhaus Andreas , Schnetzke Ulf 
Published: October 2021

Abstract
Purpose
Curative intended treatment is challenging in patients with relapsed or refractory acute myeloid leukemia (r/r AML) and associated with a dismal prognosis for long-term survival. Despite novel treatment options, the majority of patients are treated with chemotherapy-based regimens. Although widely used, little data exist on the combination of fludarabine, cytarabine, granulocyte colony stimulating factor (FLAG) and mitoxantrone as salvage strategy for r/r AML.

Materials and methods
Sixty-six patients receiving Mito-FLAG for r/r AML treated at a German tertiary care center between 2009 and 2019 were analyzed with regard to response rates, survival and safety profile.

Results
Overall response rate was 75.8% with 56.1% of patients achieving complete remission (CR) and 19.7% partial remission (PR). After a median follow-up of 54 months, median overall survival (OS) was 13 months. Patients transitioned to allogeneic hematopoietic stem cell transplantation (alloHSCT) (75.8%) showed a significant improvement in OS with a median OS of 17 (95% CI 8.5–25.4) months vs 3 (95% CI 1.7–4.3) months (p < 0.001). 30- and 60-day mortality rates for all patients after the initial cycle of Mito-FLAG were 4.5% and 7.6%, respectively.

Conclusion
The Mito-FLAG salvage protocol represents an effective and feasible treatment regimen for r/r AML. Importantly, a high rate of transition to successful alloHSCT with the aim of long-term disease-free survival has been shown.
Implementing a robotic liver resection program does not always require prior laparoscopic experience
Authors: Balzano Emanuele , Bernardi Lorenzo , Tincani Giovanni , Ghinolfi Davide , Melandro Fabio , Bronzoni Jessica , Meli Sonia , Arenga Giuseppe , Biancofiore Giandomenico , Crocetti Laura , De Simone Paolo 
Published: October 2021

Abstract
Background
Preliminary experience in laparoscopic liver surgery is usually suggested prior to implementation of a robotic liver resection program.

Methods
This was a retrospective cohort analysis of patients undergoing robotic (RLR) versus laparoscopic liver resection (LLR) for hepatocellular carcinoma at a center with concomitant initiation of robotic and laparoscopic programs

Results
A total of 92 consecutive patients operated on between May 2014 and February 2019 were included: 40 RLR versus 52 LLR. Median age (69 vs. 67; p = 0.74), male sex (62.5% vs. 59.6%; p = 0.96), incidence of chronic liver disease (97.5% vs.98.1%; p = 0.85), median model for end-stage liver disease (MELD) score (8 vs. 9; p = 0.92), and median largest nodule size (22 vs. 24 mm) were similar between RLR and LLR. In the LLR group, there was a numerically higher incidence of nodules located in segment 4 (20.0% vs. 16.6%; p = 0.79); a numerically higher use of Pringle’s maneuver (32.7% vs. 20%; p = 0.23), and a shorter duration of surgery (median of 165.5 vs. 217.5 min; p = 0.04). Incidence of complications (25% vs.32.7%; p = 0.49), blood transfusions (2.5% vs.9.6%; p = 0.21), and median length of stay (6 vs. 5; p = 0.54) were similar between RLR and LLR. The overall (OS) and recurrence-free (RFS) survival rates at 1 and 5 years were 100 and 79 and 95 and 26% for RLR versus 96.2 and 76.9 and 84.6 and 26.9% for LLR (log-rank p = 0.65 for OS and 0.72 for RFS).

Conclusions
Based on our results, concurrent implementation of a robotic and laparoscopic liver resection program appears feasible and safe, and is associated with similar oncologic long-term outcomes.
Modelling the effects of cold temperature during the reproductive stage on the yield of chickpea (Cicer arietinum L.)
Authors: Anwar Muhuddin Rajin , Luckett David J. , Chauhan Yashvir S. , Ip Ryan H. L. , Maphosa Lancelot , Simpson Marja , Warren Annie , Raman Rosy , Richards Mark F. , Pengilley Georgina , Hobson Kristy , Graham Neroli 
Published: October 2021

Abstract
During the reproductive stage, chilling temperatures and frost reduce the yield of chickpea and limit its adaptation. The adverse effects of chilling temperature and frost in terms of the threshold temperatures, impact of cold duration, and genotype-by-environment-by-management interactions are not well quantified. Crop growth models that predict flowering time and yield under diverse climates can identify combinations of cultivars and sowing time to reduce frost risk in target environments. The Agricultural Production Systems Simulator (APSIM-chickpea) model uses daily temperatures to model basic crop growth but does not include penalties for either frost damage or cold temperatures during flowering and podding stages. Regression analysis overcame this limitation of the model for chickpea crops grown at 95 locations in Australia using 70 years of historic data incorporating three cultivars and three sowing times (early, mid, and late). We modified model parameters to include the effect of soil water on thermal time calculations, which significantly improved the prediction of flowering time. Simulated data, and data from field experiments grown in Australia (2013 to 2019), showed robust predictions for flowering time (n = 29; R2 = 0.97), and grain yield (n = 22; R2 = 0.63–0.70). In addition, we identified threshold cold temperatures that significantly affected predicted yield, and combinations of locations, variety, and sowing time where the overlap between peak cold temperatures and peak flowering was minimal. Our results showed that frost and/or cold temperature–induced yield losses are a major limitation in some unexpected Australian locations, e.g., inland, subtropical latitudes in Queensland. Intermediate sowing maximise yield, as it avoids cold temperature, late heat, and drought stresses potentially limiting yield in early and late sowing respectively.
Sparse nonnegative tensor decomposition using proximal algorithm and inexact block coordinate descent scheme
Authors: Wang Deqing , Chang Zheng , Cong Fengyu 
Published: October 2021

AbstractNonnegative tensor decomposition is a versatile tool for multiway data analysis, by which the extracted components are nonnegative and usually sparse. Nevertheless, the sparsity is only a side effect and cannot be explicitly controlled without additional regularization. In this paper, we investigated the nonnegative CANDECOMP/PARAFAC (NCP) decomposition with the sparse regularization item using $$l_1$$

l
1

-norm (sparse NCP). When high sparsity is imposed, the factor matrices will contain more zero components and will not be of full column rank. Thus, the sparse NCP is prone to rank deficiency, and the algorithms of sparse NCP may not converge. In this paper, we proposed a novel model of sparse NCP with the proximal algorithm. The subproblems in the new model are strongly convex in the block coordinate descent (BCD) framework. Therefore, the new sparse NCP provides a full column rank condition and guarantees to converge to a stationary point. In addition, we proposed an inexact BCD scheme for sparse NCP, where each subproblem is updated multiple times to speed up the computation. In order to prove the effectiveness and efficiency of the sparse NCP with the proximal algorithm, we employed two optimization algorithms to solve the model, including inexact alternating nonnegative quadratic programming and inexact hierarchical alternating least squares. We evaluated the proposed sparse NCP methods by experiments on synthetic, real-world, small-scale, and large-scale tensor data. The experimental results demonstrate that our proposed algorithms can efficiently impose sparsity on factor matrices, extract meaningful sparse components, and outperform state-of-the-art methods.
Jumper’s fracture of the sacrum: a novel and reproducible way for successful reduction and fixation
Authors: Linhart Christoph , Befrui Nima , Etzel Lucas , Böcker Wolfgang , Kammerlander Christian , Ehrnthaller Christian 
Published: October 2021

Abstract
Purpose
Surgical treatment of jumper’s fractures is a highly demanding situation for the surgeon due to its rareness and frequent association with severe concomitant injuries. There is no current consensus regarding a standard treatment approach, thus reducing quality of care. Our objectives were to describe, apply and assess a novel surgical technic.

Methods
The presented research is an observational retrospective study of patients who underwent the described novel surgical intervention in a level 1 trauma center. We conducted analyses of the patient cohort using patient-related outcome measures at least 1 year after surgery, as well as investigating pain, quality of life and the clinical effectiveness of the procedure.

Results
A total of 24 patients (17 male and 7 female) with an average age 47 ± 16.3 years were included. ISS scores ranged from 9 to 66 with a mean ISS of 40 ± 15. Clinical scores exist of 15 out of 24 patients (62.5%). The mean VAS score was 53.7 ± 12.9. The mean EQ-5D index was 0.68 ± 0.22. Significant negative correlation existed between the ISS value and the EQ-5D index (r =  − 0.704; p < 0.005) and EQ-5D VAS (r =  − 0.809; p < 0.001). Anatomical reduction was achieved in all patients (n = 24). Radiological follow-up was performed in 58%.

Conclusion
We present one of the largest studies with operatively treated jumper’s fractures of the sacrum. The technique is capable of reproducibly restoring the physiological anatomy of the patient and allows pain-adapted mobilization.