bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crisis as Opportunity: Exploring the African Union's Response to COVID-19 and the Implications for Its Aspirational Supranational Powers
Authors: Fagbayibo Babatunde , Owie Udoka Ndidiamaka 
Published: September 2021

AbstractThe COVID-19 pandemic has proved challenging to states and regional organizations, exposing gaps in political leadership as well as in the preparedness of economic and public healthcare systems. As states and organizations contend with the pandemic, the African Union's response in this regard, thus far, indicates the imperative of enhanced multilateralism. Its response also provides a template for endowing the organization with assertive, binding powers over its member states and, as such, achieving its supranational aspirations. In this respect, this article argues that the African Union's display of progressive internationalism, swiftness of action, agency and legitimacy in combatting the coronavirus pandemic are elements that can be applied in sharpening its processual quest for supranationalism.
Embedding in Shawi narrations: A quantitative analysis of embedding in a post-colonial Amazonian indigenous society
Authors: Rojas-Berscia Luis Miguel , Lehecka Tomas , Claassen Simon A. , Peute A. A. K. , Escobedo Moisés Pinedo , Escobedo Segundo Pinedo , Tangoa Abimael Huiñapi , Pizango Elio Yumi 
Published: September 2021

AbstractIn this article, we provide the first quantitative account of the frequent use of embedding in Shawi, a Kawapanan language spoken in Peruvian Northwestern Amazonia. We collected a corpus of ninety-two Frog Stories (Mayer 1969) from three different field sites in 2015 and 2016. Using the glossed corpus as our data, we conducted a generalised mixed model analysis, where we predicted the use of embedding with several macrosocial variables, such as gender, age, and education level. We show that bilingualism (Amazonian Spanish-Shawi) and education, mostly restricted by complex gender differences in Shawi communities, play a significant role in the establishment of linguistic preferences in narration. Moreover, we argue that the use of embedding reflects the impact of the mestizo1 society from the nineteenth century until today in Santa Maria de Cahuapanas, reshaping not only Shawi demographics but also linguistic practices. (Post-colonial societies, Amazonian linguistics, Kawapanan, Shawi, embedding, language variation and change, contact linguistics)*
Why don't cockatoos have war songs?
Authors: Moser Cody , Ackerman Jordan , Dayer Alex , Proksch Shannon , Smaldino Paul E. 
Published: September 2021

Abstract
We suggest that the accounts offered by the target articles could be strengthened by acknowledging the role of group selection and cultural niche construction in shaping the evolutionary trajectory of human music. We argue that group level traits and highly variable cultural niches can explain the diversity of human song, but the target articles' accounts are insufficient to explain such diversity.
Musical features emerging from a biocultural musicality
Authors: Popescu Tudor , Oesch Nathan , Buck Bryony 
Published: September 2021

Abstract
Savage et al. make a compelling case, Mehr et al. less so, for social bonding and credible signalling, respectively, as the main adaptive function of human musicality. We express general advocacy for the former thesis, highlighting: (1) overlap between the two; (2) direct versus derived biological functions, and (3) aspects of music embedded in cultural evolution, for example, departures from tonality.
Social bonding and credible signaling hypotheses largely disregard the gap between animal vocalizations and human music
Authors: Zentner Marcel 
Published: September 2021

Abstract
Mehr et al. propose a theory of the evolution music that can potentially account for most animal vocalizations as precursors to human music. Therein lies its appeal but also its Achilles' heel, for the wider the range of animal vocalizations treated as premusical expressions, the wider the gap to human music. Here, I offer a few critical observations and constructive suggestions that I hope will help the authors strengthen their case.
Foundational assumption reasonable but uncertain
Authors: Wright Rex A. , Mlynski Christopher 
Published: September 2021

AbstractWe offer thoughts on Shadmehr and Ahmed's foundational assumption that behavioral intensity (vigor) is proportional to the perceived value of outcomes driving behavior (incentives). The assumption is reasonable considering classical motivational thought and scholarship in related literatures but called into question by an influential contemporary theory of motivation by Brehm. Brehm's theory suggests that the assumption is warranted in some, but not all, performance circumstances. Furthermore, proportionality between vigor and value might be generated through a deliberative goal-setting process rather than through intrinsic neural linkages.
The emergence and evolution of International Relations studies in postcolonial South Korea
Authors: Seo Jungmin , Cho Young Chul 
Published: September 2021

AbstractThis study investigates how International Relations (IR) as an academic discipline emerged and evolved in South Korea, focusing on the country's peculiar colonial and postcolonial experiences. In the process, it examines why South Korean IR has been so state-centric and positivist (American-centric), while also disclosing the ways in which international history has shaped the current state of IR in South Korea, institutionally and intellectually. It is argued that IR intellectuals in South Korea have largely reflected the political arrangement of their time, rather than demonstrate academic independence or leadership for its government and/or civil society, as they have navigated difficult power structures in world politics. Related to this, it reveals South Korean IR's twisted postcoloniality, which is the absence – or weakness – of non-Western Japanese colonial legacies in its knowledge production/system, while its embracing the West/America as an ideal and better model of modernity for South Korea's security and development. It also reveals that South Korean IR's recent quest for building a Korean School of IR to overcome its Western dependency appears to be in operation within a colonial mentality towards mainstream American IR.
Heterogenous Late Holocene Climate in the Eastern Mediterranean—The Kocain Cave Record From SW Turkey
Authors: Jacobson Matthew J. , Flohr Pascal , Gascoigne Alison , Leng Melanie J. , Sadekov Aleksey , Cheng Hai , Edwards R. Lawrence , Tüysüz Okan , Fleitmann Dominik 
Published: September 2021

AbstractPalaeoclimate variability must be constrained to predict the nature and impacts of future climate change in the Eastern Mediterranean. Here, we present a late Holocene high‐resolution multiproxy data set from Kocain Cave, the first of its kind from SW Turkey. Regional fluctuations in effective‐moisture are recorded by variations in magnesium, strontium, phosphorous and carbon isotopes, with oxygen isotopes reacting to changes in precipitation and effective‐moisture. The new record shows a double‐peak of arid conditions at 1150 and 800 BCE, a wet period 330–460 CE followed by a rapid shift to dry conditions 460–830 CE, and a dry/wet Medieval Climate Anomaly/Little Ice Age pattern. Large discrepancies exist between Turkish records and the Kocain record, which shares more similarities with other Eastern Mediterranean coastal records. Heterogeneity of regional climate and palaeoclimate proxy records are emphasized.
Diffusion‐Free Scaling in Rotating Spherical Rayleigh‐Bénard Convection
Authors: Wang Guiquan , Santelli Luca , Lohse Detlef , Verzicco Roberto , Stevens Richard J. A. M. 
Published: September 2021

AbstractDirect numerical simulations are employed to reveal three distinctly different flow regions in rotating spherical Rayleigh‐Bénard convection. In the high‐latitude region vertical (parallel to the axis of rotation) convective columns are generated between the hot inner and the cold outer sphere. The mid‐latitude region is dominated by vertically aligned convective columns formed between the Northern and Southern hemispheres of the outer sphere. The diffusion‐free scaling, which indicates bulk‐dominated convection, originates from this mid‐latitude region. In the equator region , the vortices are affected by the outer spherical boundary and are much shorter than in region .
An Observational Constraint on Aviation‐Induced Cirrus From the COVID‐19‐Induced Flight Disruption
Authors: Digby Ruth A. R. , Gillett Nathan P. , Monahan Adam H. , Cole Jason N. S. 
Published: September 2021

AbstractGlobal aviation dropped precipitously during the Covid‐19 pandemic, providing an unprecedented opportunity to study aviation‐induced cirrus (AIC). AIC is believed to be responsible for over half of aviation‐related radiative forcing, but until now, its radiative impact has only been estimated from simulations. Here, we show that satellite observations of cirrus cloud do not exhibit a detectable global response to the dramatic aviation reductions of spring 2020. These results indicate that previous model‐based estimates may overestimate AIC. In addition, we find no significant response of diurnal surface air temperature range to the 2020 aviation changes, reinforcing the findings of previous studies. Though aviation influences the climate through multiple pathways, our analysis suggests that its warming effect from cirrus changes may be smaller than previously estimated.
Crustal and Upper Mantle Structure Beneath the Southeastern United States From Joint Inversion of Receiver Functions and Rayleigh Wave Dispersion
Authors: Yang Qiuyue , Liu Kelly H. , Wang Tuo , Song Jianguo , Gao Stephen S. 
Published: September 2021

AbstractUsing data from 186 stations belonging to the USArray Transportable Array, a three‐dimensional shear wave velocity model for the southeastern United States is constructed for the top 180 km by a joint inversion of receiver functions and Rayleigh wave phase velocity dispersion computed from ambient noise and teleseismic earthquake data. The resulting shear wave velocity model and the crustal thickness and Vp/Vs () measurements show a clear spatial correspondence with major surficial geological features. The distinct low velocities observed in the depth range of 0–25 km beneath the eastern Gulf Coastal Plain reflect the thick layer of unconsolidated or poorly consolidated sediments atop the crystalline crust. The low (1.70–1.74) and slow lowermost crustal velocities observed beneath the eastern Southern Appalachian Mountains (including the Carolina Terrane and Inner Piedmont) relative to the adjacent Blue Ridge Mountains and Valley and Ridge can be interpreted by lower crustal delamination followed by relamination. The Osceola intrusive complex in the central Suwannee Terrane has similar crustal characteristics as the eastern Southern Appalachian Mountains and thus can similarly be attributed to crustal delamination/relamination processes. The Grenville Province and adjacent areas possess relatively high values which can be attributed to mafic intrusion associated with crustal extension in a recently recognized segments of the eastern arm of the Proterozoic Midcontinent Rift.
The Kyrenia Terrane (Northern Cyprus): Detrital Zircon Evidence for Exotic Elements in the Southern Neotethys
Authors: Glazer A. , Avigad D. , Morag N. , Güngör T. , Gerdes A. 
Published: September 2021

AbstractThe Kyrenia terrane of northern Cyprus comprises a tectonic stack of Triassic to Eocene rock units interleaved with basic and acid volcanics and minor metamorphic inliers, alongside an Oligocene‐Miocene flysch. Our U‐Pb‐Hf detrital zircon investigation in the Kyrenia Triassic to Eocene section reveals Precambrian, Silurian (∼430 Ma), Carboniferous (∼300 Ma), Triassic (∼240 Ma), and Upper Cretaceous (∼85 Ma) zircons. The presence of 300 Ma zircons, as early as in Triassic sediments, is enigmatic because Carboniferous magmatism is confined to the Paleotethyan realm which is traced north of the Taurides. Deposition of the Kyrenia sequence closer to a Northern Tethyan province would better fit its detrital zircon signal. The detrital signal of the Kyrenia, indicative for derivation from areas north of the Mediterranean, also differs significantly from that of the Mamonia Complex (SW Cyprus) in which only Afro‐Arabian sources are distinguished. Thus, in view of its unusual detrital zircon content, the Kyrenia sequence stands out in the Eastern Mediterranean as an exotic rock pile that cannot be straightforwardly correlated with its neighboring geologic environment. We defined the metamorphic inliers of Kyrenia as an ophiolitic mélange and recognized blueschist‐greenschist facies metamorphism to which we infer an Upper Cretaceous age. A U‐Pb zircon age of 555 ± 9 Ma (Cadomian) was obtained for the crystallization of a metabasic rock in the mélange. These findings support the geodynamic linkage of the Kyrenia with the Alanya and Bitlis massifs that were also affected by Upper Cretaceous HP‐LT metamorphism and accreted to the southern Tauride.
Effect of a common UMOD variant on kidney function, blood pressure, cognitive and physical function in a community-based cohort of older adults
Authors: Villagomez Fuentes Linda Elizabeth , Algharably Engi Abdel–Hady , Toepfer Sarah , König Maximilian , Demuth Ilja , Bertram Lars , Kreutz Reinhold , Bolbrinker Juliane 
Published: September 2021

AbstractIn genome-wide association studies, genetic variants in the UMOD gene associate with kidney function, blood pressure (BP), and hypertension. Elevated BP is linked to kidney function and impaired cognitive as well as physical performance in later life. We investigated the association between UMOD rs4293393–A > G and kidney function, BP, cognitive and physical function in the Berlin Aging Study II (BASE–II). Data of 1556 older BASE–II participants (mean age 68.2 ± 3.7 years) were analyzed. BP was determined by standardized automated measurements, estimated glomerular filtration rate (eGFR) by CKD Epidemiology Collaboration creatinine equation. Cognitive function was assessed by Mini-Mental State Examination and Digit Symbol Substitution Test, while physical function by Handgrip Strength and Timed Up and Go-Test. Association analyses were performed by covariance and logistic regression models adjusting for sex. G–allele carriers at UMOD rs4293393 exhibited significantly higher eGFR values compared to non–carriers (AA, 76.4 ml/min/1.73 m², CI: 75.7–77.2 vs. AG, 78.4 ml/min/1.73 m², CI: 77.3–79.5 vs. GG, 78.5 ml/min/1.73 m², CI: 75.4–81.7; P = 0.010), and a lower risk of eGFR < 60 mL/min/1.73 m2 (AG, OR: 0.63, CI: 0.41–0.97, P = 0.033). However, UMOD rs4293393 genotypes were not associated with BP, diagnosis of hypertension or cognitive and physical function parameters. Our data corroborate previous findings on the association of UMOD rs4293393-G with better kidney function in older adults. However, no association between UMOD and BP or physical and cognitive parameters in these community-dwelling older adults was detected.
Discovery of a new candidate drug to overcome cabazitaxel-resistant gene signature in castration-resistant prostate cancer by in silico screening
Authors: Hongo Hiroshi , Kosaka Takeo , Suzuki Yoko , Oya Mototsugu 
Published: September 2021

Abstract
Background
The taxane cabazitaxel (CBZ) is a promising treatment for docetaxel-resistant castration-resistant prostate cancer (CRPC). However, the survival benefit with CBZ for patients with CRPC is limited. This study used screening tests for candidate drugs targeting CBZ-resistant-related gene expression and identified pimozide as a potential candidate for overcoming CBZ resistance in CRPC.

Methods
We established CBZ-resistant cell lines, DU145CR and PC3CR by incubating DU145 cells and PC3 cells with gradually increasing concentrations of CBZ. We performed in silico drug screening for candidate drugs that could reprogram the gene expression signature of a CBZ-resistant prostate cancer cells using a Connectivity Map. The in vivo effect of the drug combination was tested in xenograft mice models.

Results
We identified pimozide as a promising candidate drug for CBZ-resistant CRPC. Pimozide had a significant antitumor effect on DU145CR cells. Moreover, combination treatment with pimozide and CBZ had a synergic effect for DU145CR cells in vitro and in vivo. Microarray analysis identified AURKB and KIF20A as potential targets of pimozide in CBZ-resistant CRPC. DU145CR had significantly higher AURKB and KIF20A expression compared with a non-CBZ-resistant cell line. Inhibition of AURKB and KIF20A had an antitumor effect in DU145CR xenograft tumors. Higher expression of AURKB and KIF20A was a poor prognostic factor of TGCA prostate cancer cohort. CBZ-resistant prostate cancer tissues in our institution had higher AURKB and KIF20A expression.

Conclusions
Pimozide appears to be a promising drug to overcome CBZ resistance in CRPC by targeting AURKB and KIF20A.
Corrosion inhibition of locally de-passivated surfaces by DFT study of 2-mercaptobenzothiazole on copper
Authors: Chiter Fatah , Costa Dominique , Maurice Vincent , Marcus Philippe 
Published: September 2021

AbstractInvestigating the interaction of organic inhibitors with metal and alloy surfaces is crucial for an atomic-scale understanding of their protection efficiency, particularly on the initiation of localized corrosion by pitting. Quantum chemical DFT calculations were performed to optimize the constructed model of a depassivated copper surface and to study the adsorption of 2-mercaptobenzothiazole (MBT), on different zones exposed by local depassivation. Reactive sites exist at the metal surface, at the oxide surface, as well as on the oxide edges and oxide walls. The surface-reactive sites are the unsaturated and saturated copper atoms and singly and doubly unsaturated oxygen atoms of the oxide, and the copper atoms of the metal. The sulfur (Sexo and Sendo) and nitrogen (N or NH) atoms are the reactive sites in the molecules. MBT can covalently bond to the oxide surface as well as to the oxide edges, oxide walls, and metal surface exposed by depassivation. For the thione species, local adsorption strength decreases as oxide edges > oxide surface > metal surface > oxide walls, suggesting that MBT heals the low coordinated sites. For the thiolate species, adsorption strength is similar on the different area, except the oxide walls. The results show the ability of the inhibitor to interact on different zones of a locally depassivated surface and to form a strongly adsorbed organic film, which can block the initiation of localized corrosion by enhancing the interfacial barrier properties, including in the local surface areas incompletely passivated or locally damaged by depassivation.
Does filling-dependent band renormalization aid pairing in twisted bilayer graphene?
Authors: Lewandowski Cyprian , Nadj-Perge Stevan , Chowdhury Debanjan 
Published: September 2021

AbstractMagic-angle twisted bilayer graphene (MATBG) exhibits a panoply of many-body phenomena that are intimately tied to the appearance of narrow and well-isolated electronic bands. The microscopic ingredients that are responsible for the complex experimental phenomenology include electron–electron (phonon) interactions and nontrivial Bloch wavefunctions associated with the narrow bands. Inspired by recent experiments, we focus on two independent quantities that are considerably modified by Coulomb interaction-driven band renormalization, namely the density of states and the minimal spatial extent associated with the Wannier functions. First, we show that a filling-dependent enhancement of the density of states, caused by band flattening, in combination with phonon-mediated attraction due to electron-phonon umklapp processes, increases the tendency towards superconducting pairing in a range of angles around magic-angle. Second, we demonstrate that the minimal spatial extent associated with the Wannier functions, which contributes towards increasing the superconducting phase stiffness, also develops a nontrivial enhancement due to the interaction-induced renormalization of the Bloch wavefunctions. While our modeling of superconductivity (SC) assumes a weak electron-phonon coupling and does not consider many of the likely relevant correlation effects, it explains simply the experimentally observed robustness of SC in the wide range of angles that occurs in the relevant range of fillings.
Chinese environmentally extended input-output database for 2017 and 2018
Authors: Tian Xi , Liu Yiwei , Xu Ming , Liang Sai , Liu Yaobin 
Published: September 2021

AbstractEnvironmental footprint analyses for China have gained sustained attention in the literature, which rely on quality EEIO databases based on benchmark input-output (IO) tables. The Chinese environmentally extended input-output (CEEIO) database series provide publically available EEIO databases for China for 1992, 1997, 2002, 2007, and 2012 with consistent and transparent data sources and database structure. Based on the latest benchmark IO tables for China for 2017 and 2018, here we develop the corresponding 2017 and 2018 CEEIO databases following the same method used to develop previous CEEIO databases. The 2017 and 2018 CEEIO databases cover 44 and 28 types of environmental pressures, respectively, and consider multiple sector classifications including ones consistent with previous CEEIO databases and ones following the 2017 China’s national economy industry classification standard. A notable improvement in the 2017 and 2018 CEEIO databases is the comprehensive inclusion of CO2 emissions from additional industrial processes. This work provides a consistent update of the CEEIO database and enables a wide range of timely environmental footprint analyses related to China.
Deleting a UBE3A substrate rescues impaired hippocampal physiology and learning in Angelman syndrome mice
Authors: Sell Gabrielle L. , Xin Wendy , Cook Emily K. , Zbinden Mark A. , Schaffer Thomas B. , O’Meally Robert N. , Cole Robert N. , Margolis Seth S. 
Published: September 2021

AbstractIn humans, loss-of-function mutations in the UBE3A gene lead to the neurodevelopmental disorder Angelman syndrome (AS). AS patients have severe impairments in speech, learning and memory, and motor coordination, for which there is currently no treatment. In addition, UBE3A is duplicated in > 1–2% of patients with autism spectrum disorders—a further indication of the significant role it plays in brain development. Altered expression of UBE3A, an E3 ubiquitin ligase, is hypothesized to lead to impaired levels of its target proteins, but identifying the contribution of individual UBE3A targets to UBE3A-dependent deficits remains of critical importance. Ephexin5 is a putative UBE3A substrate that has restricted expression early in development, regulates synapse formation during hippocampal development, and is abnormally elevated in AS mice, modeled by maternally-derived Ube3a gene deletion. Here, we report that Ephexin5 can be directly ubiquitylated by UBE3A. Furthermore, removing Ephexin5 from AS mice specifically rescued hippocampus-dependent behaviors, CA1 physiology, and deficits in dendritic spine number. Our findings identify Ephexin5 as a key driver of hippocampal dysfunction and related behavioral deficits in AS mouse models. These results demonstrate the exciting potential of targeting Ephexin5, and possibly other UBE3A substrates, to improve symptoms of AS and other UBE3A-related developmental disorders.