bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1
Authors: Yang Jianru , Jia Yang , Wang Bing , Yang Shengrong , Du Kun , Luo Yujie , Li Yunhe , Zhu Bing 
Published: March 2021

BackgroundThe effects of up-regulated CircCHST15 on lung cancer remained unclear. In this study, the role of CircCHST15 in lung cancer was investigated.MethodsDual-luciferase reporter verified the bioinformatics prediction that CircCHST15 targeted miR-155-5p and miR-194-5p. The correlation between CircCHST15 and PD-L1 was analyzed by Pearson analysis. CCK-8 and colony formation was performed to determine the viability and proliferation of lung cancer cells. After the lung cancer (subcutaneous-xenotransplant) model was established in mice, the T cell subtype and related cytokines in mouse tumor tissues were detected by flow cytometry and ELISA. Moreover, the expressions of CircCHST15, miR-155-5p, miR-194-5p, immune-related, and proliferation-related factors of the lung cancer cells or mice tumor tissues were detected by immunohistochemistry, RT-qPCR, or Western blot.ResultsCircCHST15 and PD-L1 were high-expressed in lung cancer, and the two was positively correlated. CircCHST15 targeted miR-155-5p and miR-194-5p, the later further targeted PD-L1. Lung cancer cell viability and proliferation were increased by miR-155-5p and inhibited by miR-194-5p. CircCHST15 located in the cytoplasm promoted tumor growth, down-regulated the expressions of miR-155-5p and miR-194-5p, and up-regulated the expressions of PD-L1, Ki-67, PCNA, CCL17, CCL22, IFN-γ, TNF-β, and IL-10. Also, CircCHST15 decreased the CD8+ cells in mouse blood and tumor, but increased the Tregs in mouse tumor. PD-L1 inhibitor showed an opposite effect to CircCHST15 on mouse tumors.ConclusionCircCHST15 sponged miR-155-5p and miR-194-5p to promote the PD-L1-mediated immune escape of lung cancer cells.
Effect of Chronic Exercise Training on Blood Lactate Metabolism Among Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Zhao Tong , Le Shenglong , Freitag Nils , Schumann Moritz , Wang Xiuqiang , Cheng Sulin 
Published: March 2021

Purpose: To assess the effect of chronic exercise training on blood lactate metabolism at rest (i.e., basal lactate concentrations) and during exercise (i.e., blood lactate concentration at a fixed load, load at a fixed blood lactate concentration, and load at the individual blood lactate threshold) among patients with type 2 diabetes mellitus (T2DM).Methods: PubMed (MedLine), Embase, Web of Science, and Scopus were searched. Randomized controlled trials, non-randomized controlled trials, and case-control studies using chronic exercise training (i.e., 4 weeks) and that assessed blood lactate concentrations at rest and during exercise in T2DM patients were included.Results: Thirteen studies were eligible for the systematic review, while 12 studies with 312 participants were included into the meta-analysis. In the pre-to-post intervention meta-analysis, chronic exercise training had no significant effect on changes in basal blood lactate concentrations (standardized mean difference (SMD) = −0.20; 95% CI, −0.55 to 0.16; p = 0.28), and the results were similar when comparing the effect of intervention and control groups. Furthermore, blood lactate concentration at a fixed load significantly decreased (SMD = −0.73; 95% CI, −1.17 to −0.29; p = 0.001), while load at a fixed blood lactate concentration increased (SMD = 0.40; 95% CI, 0.07 to 0.72; p = 0.02) after chronic exercise training. No change was observed in load at the individual blood lactate threshold (SMD = 0.28; 95% CI, −0.14 to 0.71; p = 0.20).Conclusion: Chronic exercise training does not statistically affect basal blood lactate concentrations; however, it may decrease the blood lactate concentrations during exercise, indicating improvements of physical performance capacity which is beneficial for T2DM patients' health in general. Why chronic exercise training did not affect basal blood lactate concentrations needs further investigation.
PERBEDAAN JUMLAH KOLONI STAPHYLOCOCCUS AUREUS PADA BEBERAPA KONSENTRASI PERASAN BUAH BELIMBING WULUH SECARA IN VITRO
Authors: Sudarmanto Igede 
Published: March 2021

Abstract :
Plants bilimbi (Averrhoa bilimbi Linn) has been utilized by the public as a traditional medicinal plants to cure various diseases. The content of natural chemicals from bilimbi fruits are known to have an antibacterial effect, namely, flavonoids and phenols. Methicillin Resistant Staphylococcus aureus (MRSA) is a gram-positive bacteria resistant to antibiotics semisintesis. This research aims to identify the differences in the number of colonies of Staphylococcus aureus bacteria at some concentrations of bilimbi fruit filtrate in vitro. The design of the research is a post test only control group design. Measurement of the activity of bacteria using a colony counter with dilution method. The average number of colonies of Staphylococcus aureus bacteria that grow at a concentration of bilimbi fruit filtrate 10% as much as 59.33 x 108 CFU / ml; at a concentration of 20% as much as 1.33 x 108 CFU / ml; at a concentration of 30%, 40% and 50% contained no bacterial colonies growing. At a concentration of 10 % is able to inhibit the growth of Staphylococcus aureus bacteria, while at a concentration of 30 % has been able to kill the bacteria Staphylococcus aureus. There is a difference in the number of bacterial colonies of Staphylococcus aureus in some bilimbi fruit filtrate concentration (Averrhoa bilimbi Linn) in vitro (p = 0.000
Study of P and S Wave Quality Factor (Qα and Qβ) Around Mt. Jailolo
Authors: Ulfiana Emi , Wandono Wandono , Sianipar Dimas Salomo , Heryandoko Nova 
Published: March 2021

Mt. Jailolo is a B type volcano that has never erupted after 1600. Seismic activities around Mt. Jailolo have never been recorded until the swarm in November 2015. Several studies have been done to determine thecause of the swarm, but it is not certain whether the cause of the swarm is tectonic or volcanic activities. The study of attenuation characteristics has never been carried out in the area around Mt. Jailolo. Attenuation characteristics are important to provide the medium information which seismic waves pass through and it can also be applied to the volcanic areas as preliminary disaster mitigation. The main objective of this study is to analyze attenuation characteristics often expressed by Quality factor (Q-factor) of P and S seismic wave (Qα and Qβ), which are inversely proportional to attenuation factor (1/Q). Calculations of Qα and Qβ are obtained using coda normalization method. The study area location is around Mt. Jailolo at 127.3◦ - 127.6◦E and 0.9◦ - 1.2◦ N. Data have been collected with 12 Short Period temporary 7G sensors network belongs to GFZ and BMKG. This study uses 147 swarm events from the sensors with a threshold magnitude of Mw< 5.0, during April 2017. The study obtains Qα(f) = 9.61814f 1.12981 and Qβ(f) = 19.10690f 1.22843. The current analysis concludes that the attenuation beneath Mt. Jailolo corresponds to the volcanic swarms which may have been triggered by its deeper layer’s magmatic activity.
منهج القرآن الكريم في وجوب النظر
Authors: حاتم م.م آلاء سالم 
Published: March 2021

يهدف البحث إلى دراسة موضوع من الموضوعات القرآنية العبادية العقائدية المهمة التي عُرِف فضلها وجُهِل ثمرها ، ولأهمية الموضوع ارتأيت الكتابة فيه, فجاء موضوع بحثي ((منهج القرآن الكريم في وجوب النظر)) وقد قسمت البحث إلى مقدمة وثلاثة مطالب وخاتمة بأهم نتائج البحث:
أما المقدمة، فقد تناولت فيها سبب اختياري للموضوع وأهميته .
أما المطلب الاول , فكان لبيان مضمون النظر لغةً واصطلاحاً وأهميته .
واما المطلب الثاني ، فقد تناولت فيه أنواع وجوب النظر وشروطه.
وجاء المطلب الأخير ليتحدث عن مجالات وجوب النظر.
أما الخاتمة , فكانت لبيان أهم نتائج البحث فخرجت بنتيجة مهمة وهي: أن التفكر من العبادات القلبية العظيمة وانفعها له والتي مناطها العقل.
الظل المدمر: دراسة تحليلية نفسية لمارجريت آتوود أوريكس وكريك
Authors: صدام م.د. وداد علاوي 
Published: March 2021

الظل هو ذلك الجزء الخفي أو المكبوت للنفس البشرية الذي قد يتعارض مع المعتقدات الأخلاقية للشخص .يتحدث كارل سي يونج عن أهمية هذا الجزء ويؤكد ان ثمة صراع قد ينشأ إذا حدث التغاضي عن هذا الجانب المظلم للإنسان. الشخصية التي تجسدت فيها ملامح هذا الظل المدمر بشكل خاص هي شخصية كريك في الرواية المختارة لهذه الدراسة "“Oryx and Crake. يصنع كريك مخلوقات جديدة محاولا جعلها بلا عيوب. يمتلك كريك هذه الأنا التي تجعله يحاول تحويل العالم بشكل أفضل ؛ لكنه لم يغير نفسه. الشخصيات الأخرى في الرواية بطريقة ، أو بأخرى تتحكم فيها أيضًا مشكلات نفسية. الرواية هي مثال جيد لتصوير تلك الشخصيات مع مشاكلها النفسية .و لدراسة هذه الرواية أهمية عميقة من حيث يمكن مقارنتها بسهولة مع حياتنا. تبين الرواية إن إتقان العلوم يمنح البشر فخرًا وغرورًا مزيفين لمحاولة تحدي الطبيعة والسيطرة على العالم بأسره ، ويعد كريك رمزًا لهذه الإيديولوجية التي تهدف إلى تدمير العالم. تسلط الدراسة الضوء على جزء من المشكلات النفسية ، وتحلل القوة المدمرة للظل كما ناقشها يونج وعلاقتها أو تأثيرها في حياة الإنسان وكيف تشوه حقيقة هذه الشخصيات وغيرها.
متطلبات توظيف التعلم الذكي في العملية التعلمية – التعليمية في جامعة الاستقلال من وجهة نظر أعضاء هيأة التدريس
Authors: سويدان د. رجاء روحي 
Published: March 2021

ﻫدﻓت ﻫذﻩ اﻟدراﺳﺔ الى معرفة متطلبات توظيف التعلم الذكي في العملية التعلمية- التعليمية في جامعة الاستقلال من وجهة نظر أعضاء هيئة التدريس. استخدمت الباحثة الاستبانة كأداة لجمع المعلومات التي تكونت من (36) فقرة وضمت أربعة مجالات وهي: الأبنية والأجهزة والمعدات، البرامج والتقنيات، الكادر البشري والتنظيمي، مواصفات المنهاج الإلكتروني، اشتملت على عينة البحث (100) عضو من أعضاء الهيئة التدريسية في جامعة الاستقلال. وأظهرت نتائج الدراسة أن متطلبات المنهاج الإلكتروني ومواصفاته حصلت على درجة عالية من الاهتمام وذات الأولوية من قبل أعضاء هيأة التدريس لتوفيرها في العملية التعلمية- التعليمية في الجامعة، وكانت أعلى بنود هذا المجال الفقرة التي تطلب تنويع أساليب التقويم، حيث كانت بوزن نسبي قدره (96.71%). فيما كانت الدرجة الثانية من متطلبات توظيف التعلم الذكي في العلمية التعلمية- التعليمية في جامعة الاستقلال من وجهة نظر أعضاء هيئة التدريس فكانت بضرورة توفير الكادر البشري والتنظيمي، وركزت مطالب هذا المجال على ضرورة توفر عضو هيئة تدريس قادر على استخدام تقنيات وتطبيقات التعلم الذكي، حيث حصلت على وزن نسبي قدره (88.33%). أما الدرجة الثالثة من متطلبات توظيف التعلم الذكي في العلمية التعلمية- التعليمية في جامعة الاستقلال من وجهة نظر أعضاء هيأة التدريس كانت متطلبات البرامج والتقنيات، فقد ركزت مطالب هذا المجال على ضرورة توفير برامج الاستجابة التفاعلية، وحصلت على وزن نسبي قدره (85.03%). وأخيراً حصلت الأبنية والمعدات والأجهزة على الدرجة الرابعة والأخيرة من متطلبات توظيف التعلم الذكي في العلمية التعلمية-التعليمية في جامعة الاستقلال من وجهة نظر أعضاء هيئة التدريس، فقد ركزت مطالب هذا المجال على توفير قاعات دراسية تحتوي على الأجهزة اللازمة لاستخدام التعلم الذكي، وحصلت على وزن نسبي قدره(84.8%). وأوصت الدراسة بضرورة الاستفادة من المتطلبات التي حددتها الدراسة في توظيف التعلم الذكي في العملية التعلمية- التعليمية في جامعة الاستقلال.
SPECTRAL CHARACTERISTICS OF A ELLIPTICAL OPERATOR ON THE GRAPH-STAR
Authors: Райхельгауз Л.Б. , Баскакова Д.В. , Строева М.Ю. 
Published: March 2021

Работа посвящена изучению спектра краевой задачи для обыкновенного дифференциального уравнения на графе-звезде, порожденного эллиптическим оператором. Такие краевые задачи возникают при анализе как эволюционных, так и динамических процессов в задачах тепломассопереноса сплошных сред и задачах колебаний упругих промышленных конструкций. Примерами могут служить перенос вязких жидкостей в сетевых гидроносителях и волновые процессы в сетеподобных антенных конструкциях.
The work is devoted to the study of the spectrum of the boundary problem for the ordinary differential equation on the graph-star generated by the elliptical operator. Such the boundary problem arise when analyzing both evolutionary and dynamic processes in the tasks of heat-mass-carrying of solid environments and the tasks of oscillations of elastic industrial structures. Examples include the transfer of viscous fluids in network hydro-carrier and wave processes in network-like antenna structures.
RESEARCH ON THE EFFECTIVENESS OF AN OPEN CLASSIFIER OF MASS MEDIA PUBLICATIONS BASED ON A RELATIONAL DATABASE
Authors: Тараканов О.В. , Баженова А.Д. 
Published: March 2021

Статья посвящена устранению противоречия между высокой точностью классификации и низкой целостностью классификатора, используемого для рубрикации публикаций средств массовой информации. Наиболее эффективным способом устранения подобных противоречий является автоматизация процесса.
The article is devoted to the elimination of the contradiction between the high accuracy of classification and the low integrity of the classifier used for the categorization of mass media publications. The most effective way to eliminate such contradictions is to automate the process. A logical scheme of the information storage structure of the open classifier of media publications has been developed.
METHODOLOGY FOR EVALUATING THE VALUE OF DEPLOYING IT SERVICES TO AUTOMATE ORGANIZATIONS
Authors: Абдалов А.В. 
Published: March 2021

В работе рассмотрен функционал программного обеспечения, разработанного для программной оценки ценности реализации ИТ-сервисов для автоматизации процесса создания ИТ-сервисов организации. Предложена стоимостная функция для получения эффекта от ИТ-сервисов организации.
The paper considers the functionality of software developed for software evaluation of the value of implementing it services to automate the process of creating it services for an organization. A cost function is proposed for getting the effect of an organization's it services.
COST-OPTIMIZED HEURISTIC ALGORITHM FOR SCHEDULING WORKFLOWS IN THE CLOUD ENVIRONMENT OF IAAS SERVICES
Authors: Спицын А.А. 
Published: March 2021

В статье основное внимание уделено решению проблемы планирования рабочего процесса. Представлен эвристический алгоритм для планирования рабочих процессов в облачных вычислениях.
The article focuses on solving the problem of workflow planning. A heuristic algorithm for scheduling workflows in cloud computing is presented.
ANALYSIS OF CUSTOMER CHURN INDICATORS FROM THE BIG TECHNICAL DATA STREAM
Authors: Тагиев Н.Р. 
Published: March 2021

По мере роста операторов мобильной связи и постоянного появления новых услуг объем данных, подлежащих анализу, растет экспоненциально. Им нужны более мощные, эффективные и точные возможности анализа данных, чтобы не отставать. Данная статья посвящена анализу важных показателей, которые могут повлиять на отток клиентов из потока данных OSS-big database. Дана группировка и сравнительный анализ показателей, влияющих на абонента.
As mobile network operators grow and new services emerge all the time, the data that needs to be analyzed grows exponentially. They need more powerful, efficient, and accurate data analysis capabilities to keep up. This paper is devoted to the analysis of important indicators that can affect customer churn from the OSS-big database data stream.
The First Fast Radio Burst Detected with VLITE-Fast
Authors: Bethapudi Suryarao , Kerr Matthew , Ray Paul S. , Clarke Tracy E. , Kassim Namir E. , Deneva Julia S. 
Published: March 2021

Abstract
The VLITE-Fast experiment combines the wide-field-of-view of single dish antennas operating at low frequency with the high angular resolution furnished by the 3–30 km baselines of the VLA, making it ideal for the detection and precise localization of radio transients. We describe the VLITE-Fast experiment, its capabilities, and operational status, and we briefly overview its main science case, the detection of fast radio bursts (FRBs) and determination of their host galaxies. We report on commissioning observations in an incoherent mode prohibiting precise localization. These include discovery of FRB 20200405A, detected during early science operations at dispersion measure (DM) = 212.3 pc cm−3, strongly in excess of the Galactic DM along the line of sight.
Description of a new species of Zeuxevania Kieffer (Hymenoptera: Evaniidae) from India with a key to species
Authors: Kazmi Sarfrazul , Rameshkumar Anandhan 
Published: March 2021

Taxonomy and diversity of Evaniidae from India have not been studied in depth and hosts of many species are unknown. Out of 31 world genera, only five genera (Evania Fab., Prosevania Kieffer, Szepligetella Bradley, Vernevania Huben &amp; Deans and Zeuxevania Kieffer) are reported from India. Based on the collection deposited in the Hymenoptera section of Zoological Survey of India (National Zoological Collection), here we are describing a new species of the genus Zeuxevania.
A new evaniid species Zeuxevania hubeni sp. nov. is described, based on a female specimen collected from Kadaludi Bird Sanctuary, Kerala, India. The new species is compared with Z. curvicarinata (Cameron), as well as Z. kasauliensis (Muzaffer) and a key to Indian species, based on females, is provided. The type specimen is deposited in the National Zoological Collection, Zoological Survey of India, Kolkata, India.
Vascularised fibular graft in the management of non-union of fracture shaft of radius: a less ventured entity
Authors: K. Panigrahi Tapas , C. Maharaj Ramesh , P. Nanda Debi 
Published: March 2021

Introduction: Non-union of the radius and ulna is a major complication of forearm fractures, accounting upto 10% of all forearm fractures. Multiple modalities are available for the treatment of non-union. Vascular grafts are a less sought-after surgical choice owing to the need of expertise and skills of surgeons. We discuss a case of gap non-union of fracture shaft radius treated with vascular fibula graft.
Case Report: We describe a case of 45yr old lady with closed fracture of both bones of left forearm. She underwent open reduction and internal fixation with 3.5 small DCP (6 hole) two days following trauma. On subsequent follow up in 6 months the radius fracture showed signs of infected non-union with osteolysis at screw sites while the ulnar side showed signs of satisfactory union. The patient underwent debridement with implant removal and osteosynthesis with vascularised fibula for gap non-union as second stage. 3 and 6 months follow up showed improvement in DASH score as well as VAS score and fair return of regular activity.
Conclusion: In management of gap non-union of Shaft radius with gap (>6cm) vascularised fibular graft provides excellent functional outcome with far less donor site complications.
Computational analyses of heat flux of wall Y+ in supercritical fluid using star – Ccm+ Cfd code
Authors: Enaroseha Omamoke O. E. , Ojegu Ernest Ogheneruona 
Published: March 2021

Theoretical modeling techniques on resolving turbulent heat flows in a nondimensionalcircular tube mounted obstacle using the wall Y+ as guidance in selecting the appropriate grid configuration and corresponding turbulence models are investigated using CFD Code. The results obtained shows that the heat fluxes of 20, 23, 30 and 40 kW/m2, increases as the Y+wall profile moves away from the near – wall region, this is due to the effect of viscosity, buoyance, acceleration and the friction of the turbulence modification.The results also indicates that the low Y+wall treatment is suitable only for low Reynolds turbulence models in which it is assumed that the viscous sub-layer is properly resolved. The simulated results obtained in this research are in good agreements with the experimental results in the literature,even though they over predicted the observed heat transfer deterioration both quantitatively and qualitatively.
Keywords: Wall Y+ , Turbulence, Supercritical fluid, Heat flux
Evidence of terrestrial organic carbon inputs on Niger Delta Sea Shelf
Authors: Uzoegbu M.U. 
Published: March 2021

The objective of this research is to determine the actual source of organic matter in the Niger Delta Sea Shelf (NDSS). Organic carbon (OC) and n-alkanes were investigated in the suspended matter (SM) and surfcial sediments of the Niger and Imo Rivers and the opposite Niger Delta Sea Shelf. Organic nitrogen and carbon isotope (δ13C) values were determined as additional parameters in the sediments. OC and n-alkane concentrations were highly variable. This variability was interpreted as the result of sources of materials from the inland basins and a complex sedimentation pattern involving the discharges of these two rivers. Using the constant ratio of high molecular weight odd n-alkanes to OC in both rivers, the estimated value of more than 70% of the OC preserved in shelf sediments were terrestrially-derived. This result was substantiated by the overall dominance of land-derived n-alkanes. A second approach using δ13C values and assuming binary dilution of riverine and marine OC led to the determined source of organic matter.
Keywords: Organic carbon; δ13C; n-Alkanes; Niger River; Imo River; Niger Delta Sea Shelf.
Experience of transcatheter device closure of atrial septal defect in a tertiary care institute
Authors: Muhammad Younas  , Ahsan Beg  , Tauseef Asma  , Baqir Maqbool  
Published: March 2021

Abstract
Objective: To share our experience of transcatheter device closure of secundum atrial septal defect in children and adults.
Methods: This descriptive cross-sectional study was conducted at department of Paediatric Cardiology Ch. Pervaiz Elahi Institute of Cardiology Multan from 2011 to September 2019. Patients with moderate to large ASD secundum without severe pulmonary hypertension were studied. All procedures were performed under general anaesthesia and trans-Oesophageal echo guidance. Success and safety of procedure were evaluated.
Results: During study period, a total of 75 patients underwent ASD device closure. Mean age was 25 ± 1.53 (4 -54 years) and male to female ratio 1:2. Mean defect was 20.38 ± 0.58 (09 to 32 mm). Large defects (> 25 mm) were 17 (22.7 %). Significant PS (> 30 mm Hg) observed in three and valvuloplasty performed. Device size was selected on the basis of TOE measurement + 4-5 mm. Balloon sizing was performed in only three patients. Amplatzer septal occluder was used in 80 %. Balloon assisted technique was used in 09 (12 %) patients. All the procedures were successful except two (2.7 %) where device embolized and retrieved by surgery. Transient arrhythmias were observed in 05 (6.6 %) and small pericardial effusion which was managed conservatively in one patient. There was no procedure related mortality.
Conclusion: Transcatheter closure of moderate to large ASD secundum in children and adults is a safe procedure. Among the major events, device embolizaion was common. Other complications were rare including small pericardial effusion and transient arrhythmias.
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Need of the hour: finding alternatives to a centralized Emergency Medical Services (EMS) system in Pakistan
Authors: Syeda Kanza Kazmi  , Fatima Muhammad Asad Khan  , Ibtehaj-Ul-Haque  
Published: March 2021

The WHO recognizes Pakistan to be on of the top contributors to mortalities related to accidents and road trafiic injuries. The lack of awareness and education in the general population and lack of adequate training about Basic Life Support (BLS) and trauma management in healthcare professionals in Pakistan play a pivotal role in causing this grim situation. Lack of funds allocated to healthcare system specfically the Emergency services is one of the many root causes leading to a significant number of preventable mortalities.
These injuries lead to lifelong and irreversible effects on both the physical and mental health of those involved. Moreover, it leads to unnecsserary strain on the already burdened healthcare system. Thus,immediate nationwide efforts are needed to create a system which is updated and capable enough to filter, classify and handle the emergencies. This system must be centralized, should be able to train people and make its own policies. This will ultimately lead to a better management at the emergency site and swift transitioning to the healthcare facility.
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