bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a child-rearing promotion of sexual abstinence scale (CPSAS) in Thai female adolescents at two Thai universities
Authors: Wannarit La-Ongdao , Chaiyawat Waraporn , Yunibhand Jintana 
Published: June 2021

PurposeChild-rearing promoting sexual abstinence has strongly predicted sexual abstinence in Thai female adolescents, and it requires a valid and reliable measurement. However, no such instrument exists. This study aimed to develop a child-rearing promotion of sexual abstinence scale (CPSAS) and assess its validity and reliability.Design/methodology/approachThe scale development consisted of two phases; scale construction and psychometric testing. Phase I included item generation extracted from a literature review and existing measurements. Items were reviewed by five-panel experts and were then selected by considering an inter-item correlation, corrected item-total correlation, factor loading and communality value from the exploratory factor analysis (n = 299). Phase II involved confirmatory factor analysis (CFA) for construct validity and scale reliability (n = 300).FindingsThe CPSAS, first, contained 25 items with four dimensions; assuring daughter to recognize parental love, teaching daughter sexual abstinence, convincing daughter to recognize parent's expectations of sexual abstinence and encouraging daughter sexual abstinence. Two items were then deleted after the experts reviewed, and six items were removed after item analysis. The CPSAS finally contained 17 items with a 4-point Likert scale. Psychometric testing provided acceptable results. CFA reported the fit indices; χ2 = 98.06 p = 0.083, df = 80, χ2/df ratio = 1.220, CFI = 0.996, TLI = 0.992, RMSEA = 0.027 and SRMR = 0.030. The standardized factor loadings were 0.499 to 0.908 (p < 0.05). The S-CVI was 0.96, and Cronbach's alpha coefficient was 0.93.Originality/valueThe CPSAS is a reliable and valid instrument for evaluating child-rearing promoting sexual abstinence in Thai female adolescents.
The value in doing good: perspective from the Indian manufacturing sector
Authors: Jha Ankur 
Published: June 2021

Purpose
This study aims to identity the component of corporate social responsibility (CSR) and examine its role in industrial brand equity creation. This study examines the path via value proposition derived by industrial buyers through social performance of suppliers.

Design/methodology/approach
Drawing from the means-end chain paradigm, this study develops a conceptual model illustrating consequences of CSR perception. The model is empirically tested with 404 purchasing managers of manufacturing firms in India.

Findings
This study finds an empirical link between the CSR perception among industry buyers with consumption value and subsequent impact on industrial brand equity of suppliers. This study addresses the conundrum related to the role of social performance of supplier in purchase decision.

Research limitations/implications
The brand preference decision among industrial buyers has majorly focused on price quality conundrum. The supplier groups emphasis on providing the value to customer group across the price quality continuum. However, with growing importance of social accountability, the social performance of suppliers has become integral to decision-making for decision-makers. The supplier groups are expected to create offering with amalgamation of social responsiveness.

Originality/value
To the best of the author’s knowledge, this study is the first to demonstrate the impact of CSR perception on value proposition for industrial buyers. Multiple theories have advanced the importance of value in brand equity; the empirical study is probably first in the context.
Teaching for international mindedness in Chicago Public Schools International Baccalaureate humanities classes
Authors: Tocci Charles , Ryan Ann Marie , Ensminger David C. , Rismiati Catur , Moughania Ahlam Bazzi 
Published: June 2021

PurposeThe International Baccalaureate (IB) programme centers on developing students' international mindedness. Central to this effort is the programme's “Learner Profile,” which details ten attributes that teachers seek to cultivate through classroom instruction. This article reports on the ways that middle grades and high school social studies and English teachers in Chicago Public Schools' (CPS) IB programmes are attempting to implement the Learner Profile as part of their classroom practice to support students' international mindedness.Design/methodology/approachThe project was carried out as a two phase, sequential mixed-methods design. Phase I entailed a survey of IB teachers and programme coordinators across CPS to assess the incorporation of the Learner Profile into instruction. Phase II consisted of mixed-methods case studies of CPS IB programmes selected partially on Phase I data analysis.FindingsWe find that while teachers express high levels of familiarity with the Learner Profile attributes and confidence in incorporating them into practice, we find wide variation in the actual implementation. Taken as a whole, we find CPS programmes take divergent approaches to incorporating the Learner Profile based on differences in understanding of the attributes and its purposes as well as key organizational facets related to implementation.Originality/valueUltimately, we argue that the wide variation and lack of explicit incorporation of the Learner Profile into classrooms is related in large part to the broad, indistinct nature of “international mindedness” as a concept. The programme would benefit from creating more space for teacher and students to critique the concept, especially those working from non-Western traditions.
Artificial intelligence and imaging biomarkers for prostate radiation therapy during and after treatment
Authors: Wang Yu‐Feng , Tadimalla Sirisha , Hayden Amy J. , Holloway Lois , Haworth Annette 
Published: June 2021

AbstractMagnetic resonance imaging (MRI) is increasingly used in the management of prostate cancer (PCa). Quantitative MRI (qMRI) parameters, derived from multi‐parametric MRI, provide indirect measures of tumour characteristics such as cellularity, angiogenesis and hypoxia. Using Artificial Intelligence (AI), relevant information and patterns can be efficiently identified in these complex data to develop quantitative imaging biomarkers (QIBs) of tumour function and biology. Such QIBs have already demonstrated potential in the diagnosis and staging of PCa. In this review, we explore the role of these QIBs in monitoring treatment response during and after PCa radiotherapy (RT). Recurrence of PCa after RT is not uncommon, and early detection prior to development of metastases provides an opportunity for salvage treatments with curative intent. However, the current method of monitoring treatment response using prostate‐specific antigen levels lacks specificity. QIBs, derived from qMRI and developed using AI techniques, can be used to monitor biological changes post‐RT providing the potential for accurate and early diagnosis of recurrent disease.
Coronary heart disease in mothers and fathers of adult children with alcohol use disorders
Authors: Calling Susanna , Ohlsson Henrik , Sundquist Jan , Kendler Kenneth S. , Sundquist Kristina 
Published: June 2021

AbstractBackground and aimHaving a family member with an alcohol use disorder (AUD) may negatively affect a person's health. Our aim was to study the long‐term risk of coronary heart disease (CHD) in parents who have an offspring with AUD.DesignCohort study with Cox regression models and co‐sibling analyses.SettingSweden.ParticipantsFrom population registers, we selected all parent‐offspring pairs in which the parent was born in Sweden between 1945 and 1965.MeasurementsBaseline was set when the offspring was 15 years old and AUD was assessed from medical and criminal registers. The parents were followed for CHD during a mean follow‐up of 18 years. Hazard ratios (HRs) in mothers and fathers were calculated and adjusted for potential confounders (year of birth, age at childbirth, sex of the child, parent' AUD, educational level, and marital status).FindingsIn mothers, the adjusted HR for CHD was 1.24 (95% CI = 1.19–1.28) in relation to having a child with AUD. In fathers, the HR for CHD was lower than in mothers but still increased; the adjusted HR was 1.08 (95% CI = 1.05–1.12). In the co‐sibling analyses, the HRs for mothers were similar to the HRs estimated from the population‐based sample, but in fathers the association did not remain significant (HR = 0.98 [0.90–1.06]).ConclusionsIn Sweden, there appears to be an association between having an offspring with alcohol use disorder and increased risk of developing coronary heart disease. For fathers, the association did not remain in co‐sibling analyses.
Effects of various thicknesses and levels of mineral trioxide aggregate coronal plugs on nanoleakage and fracture resistance in revascularization: An in vitro study
Authors: Gunal Esin , Bezgin Tugba , Ocak Mert , Bilecenoglu Burak 
Published: June 2021

AbstractThe aim of this study was to evaluate the effects of mineral trioxide aggregate (MTA) applied at varying levels and thickness in the cervical region of the root on the leakage and fracture resistance of the simulated immature teeth. 3 study groups (n = 16) (Group 1: 2 mm MTA, Group 2: 4 mm MTA, Group 3: 2 mm MTA+2 mm RMGIC below cementoenamel junction) and 2 control groups (Group 4: Complete canal obturation, Group 5: No coronal plug) were used for the study. Nanoleakage was measured using a micro‐computed tomography system. For the fracture resistance test, a universal testing machine was used. The amount of silver nitrate penetration decreased while MTA thicknesses increased (P < 0.001). However, the placement of MTA as a thicker layer did not make any additional contribution on the fracture resistance (P > 0.05). The 4‐mm coronal MTA plug can be suggested in RETs for its superior sealing and reinforcement abilities.
The effect of intracanal medication variations on microhardness of simulated immature root dentin
Authors: Serdar Eymirli Pınar , Eymirli Ayhan , Uzunoğlu Özyürek Emel 
Published: June 2021

AbstractThe effect of different medicaments and irrigation solutions on root dentin microhardness (MH) was evaluated depending on time. After initial measurements, MH of 60 maxillary incisors (n = 15 per group) was measured after 3 steps: irrigation with 2.5% sodium hypochlorite, exposure to medicaments [triple antibiotic (TAP) or calcium hydroxide (CH) pastes, 1 week or 1 month)] and final irrigation [20 mL of 17% EDTA or 20 mL 1% phytic acid (PA)]. The percentage of MH reduction was calculated. Data were analysed statistically atP < 0.05. Treatments caused a significant decrease in MH values compared to baseline and pre‐measurements (P < 0.05). TAP significantly reduced the MH values of the samples over time (P < 0.05). Removal of TAP after 1 month with PA resulted in a significant reduction in MH compared to removing TAP after 1 week and CH removing after 1 month (P < 0.05). Considering the chemical preparation steps, the most hazardous effect on MH was observed after the first irrigation.
Patient‐reported fatigue refines prognosis in higher‐risk myelodysplastic syndromes (MDS): a MDS‐CAN study
Authors: Amitai Irina , Geddes Michelle , Zhu Nancy , Keating Mary‐Margaret , Sabloff Mitchell , Christou Grace , Leber Brian , Khalaf Dina , Leitch Heather A. , St‐Hilaire Eve , Finn Nicholas , Shamy April , Yee Karen , Storring John , Nevill Thomas , Delage Robert , Elemary Mohamed , Banerji Versha , Chodirker Lisa , Mozessohn Lee , Parmentier Anne , Siddiqui Mohammed , Mamedov Alexandre , Zhang Liying , Buckstein Rena 
Published: June 2021

SummaryThe incorporation of patient‐reported outcomes with traditional disease risk classification was found to strengthen survival prediction in patients with myelodysplastic syndromes (MDS). In the present Canadian MDS registry analysis, we validate a recently reported prognostic model, the Fatigue‐International Prognostic Scoring System among higher‐risk patients [FA‐IPSS(h)], which incorporates patients’ reported fatigue, assessed by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life‐Core 30 (QLQ‐C30), with a threshold of ≥45 points, in higher IPSS score, stratifying them into distinct subgroups with different survival outcomes. We further validated this concept, using the Revised IPSS >3·5 as cut‐off for the definition of higher‐risk MDS, and patients’ reported fatigue according to Edmonton Symptom Self‐Assessment Scale (ESAS) Global Fatigue Scale (GFS), a single‐item fatigue rating scale, which is easier to deploy. This emphasises the power of self‐reported fatigue at refining overall survival predictions in higher‐risk MDS and further bolsters the importance of considering patient‐related outcomes in global assessments.
Neutrophil elastase promotes neointimal hyperplasia by targeting toll‐like receptor 4 (TLR4)–NF‐κB signalling
Authors: Yang Mei , Chen Qishan , Mei Li , Wen Guanmei , An Weiwei , Zhou Xinmiao , Niu Kaiyuan , Liu Chenxin , Ren Meixia , Sun Kun , Xiao Qingzhong , Zhang Li 
Published: June 2021

Background and PurposeNeointimal hyperplasia (NIH) is the fundamental cause for vascular diseases and vascular smooth muscle cell (VSMC) dysregulation has been widely implicated in NIH. Neutrophil elastase is a potential therapeutic target for multiple diseases. We investigated the role of neutrophil elastase in VSMC functions and injury‐induced NIH and explored the therapeutic potential of targeting neutrophil elastase in NIH.Experimental ApproachVSMCs were used to analyse the effects of neutrophil elastase. Proteomic analysis was used to identify potential neutrophil elastase targets. Artery injury model and neutrophil elastase inhibitor GW311616A were used to investigate the role of neutrophil elastase in NIH.Key ResultsTNF‐α up‐regulated neutrophil elastase in VSMCs through modulating GAPBα/Runx1/CEBPα/c‐Myb signalling. Up‐regulated neutrophil elastase promoted VSMC migration, proliferation and inflammation. Toll‐like receptor 4 (TLR4) was identified as a target protein for neutrophil elastase in VSMCs and the TLR4/MyD88/IRAK1/TRAF6/NF‐κB regulatory axis was shown to be the signalling pathway for neutrophil elastase in VSMC pathology. Importantly, TLR4 inhibition abolished neutrophil elastase‐mediated VSMC dysregulation. Injury‐induced NIH was significantly reduced in both neutrophil elastase‐deficient mice and mice treated with GW311616A. The formation of neutrophil extracellular traps was impaired in injured arteries from neutrophil elastase‐deficient mice. Finally, a similar role for neutrophil elastase in human VSMC pathology was confirmed and we observed higher expression levels of neutrophil elastase but lower expression levels of TLR4 in human atherosclerotic lesions.Conclusion and ImplicationsWe provide new insight into the molecular mechanisms underlying NIH and identify neutrophil elastase as a potential therapeutic target for vascular disease.
A figurational approach to understanding school climate and peer harassment: Possibilities from Norbert Elias’s work
Authors: Webb Andrew 
Published: June 2021

AbstractAlthough psychological approaches have been the mainstay of scholarly research on school climate, offering state‐of‐the‐art measurements and methodologies, sociological perspectives remain essential perspectives because violence is essentially a social phenomenon. This paper offers a theoretical consideration of contributions to this field, focusing specifically on those that provide a critical historical lens. I suggest that while Foucault's approach to the disciplining of docile bodies and self‐restraint offers crucial conceptual tools, Norbert Elias's work—which is scarce in scholarly research on school climate—provides a complementary but necessary framework for understanding emotional and relational aspects of peer harassment.
Metabolomic profiling of extraesophageal reflux disease in children
Authors: Mahoney Lisa B. , Esther Charles R. , May Kara , Rosen Rachel 
Published: June 2021

AbstractAlthough respiratory symptoms in children are often attributed to gastroesophageal reflux disease, establishing a clear diagnosis of extraesophageal reflux disease (EERD) can be challenging, as there are no sensitive or specific EERD biomarkers. The aim of this study was to evaluate the metabolite profile in bronchoalveolar (BAL) fluid from children with suspected EERD and assess the impact of reflux treatment on these metabolites. In this prospective pilot study, we performed nontargeted global metabolomic profiling on BAL fluid from 43 children undergoing testing with bronchoscopy, upper endoscopy, and multichannel intraluminal impedance with pH (pH‐MII) for evaluation of chronic respiratory symptoms. Twenty‐three (54%) patients had an abnormal pH‐MII study. Seventeen (40%) patients were on proton pump inhibitors (PPIs) for testing. Levels of histamine, malate, adenosine 5′‐monophosphate, and ascorbate were significantly lower in subjects with abnormal pH‐MII studies compared to those normal studies. Furthermore, in children off PPI therapy, those with abnormal pH‐MII studies had robust increases in a number of glycerophospholipids within phospholipid metabolic pathways, including derivatives of glycerophosphorylcholine, glycerophosphoglycerol, and glycerophosphoinositol, compared to those with normal pH‐MII studies. These findings offer insight into the impact of reflux and PPIs on the lungs and provide a foundation for future studies using targeted metabolomic analysis to identify potential biomarkers of EERD.
Developmental changes in auditory‐evoked neural activity underlie infants’ links between language and cognition
Authors: Woodruff Carr Kali , Perszyk Danielle R. , Norton Elizabeth S. , Voss Joel L. , Poeppel David , Waxman Sandra R. 
Published: June 2021

AbstractThe power and precision with which humans link language to cognition is unique to our species. By 3–4 months of age, infants have already established this link: simply listening to human language facilitates infants’ success in fundamental cognitive processes. Initially, this link to cognition is also engaged by a broader set of acoustic stimuli, including non‐human primate vocalizations (but not other sounds, like backwards speech). But by 6 months, non‐human primate vocalizations no longer confer this cognitive advantage that persists for speech. What remains unknown is the mechanism by which these sounds influence infant cognition, and how this initially broader set of privileged sounds narrows to only human speech between 4 and 6 months. Here, we recorded 4‐ and 6‐month‐olds’ EEG responses to acoustic stimuli whose behavioral effects on infant object categorization have been previously established: infant‐directed speech, backwards speech, and non‐human primate vocalizations. We document that by 6 months, infants’ 4–9 Hz neural activity is modulated in response to infant‐directed speech and non‐human primate vocalizations (the two stimuli that initially support categorization), but that 4–9 Hz neural activity is not modulated at either age by backward speech (an acoustic stimulus that doesn't support categorization at either age). These results advance the prior behavioral evidence to suggest that by 6 months, speech and non‐human primate vocalizations elicit distinct changes in infants’ cognitive state, influencing performance on foundational cognitive tasks such as object categorization.
Rodent studies of developmental programming and ageing mechanisms
Authors: Zambrano Elena , Lomas‐Soria Consuelo , Nathanielsz Peter W. 
Published: June 2021

AbstractCompelling evidence exists indicating that developmental programming influences ageing. Programming alters life‐course phenotype in multiple organs, predisposing to diseases such as diabetes, obesity and cardiovascular disease that shorten lifespan. This review describes studies in rodents, the most commonly studied species, addressing interactions of programming challenges with ageing. We first consider ageing and programming of insulin function that has been clearly shown to decrease with age. It is important to evaluate ageing in pancreatic islets isolated from other systems. Studies discussed show premature pancreatic islet ageing resulting from both maternal under‐ and overnutrition. New ways to determine programming of adipose tissue and effects on fat storage are explored. Oxidative stress is a major factor that regulates ageing in tissues. Oxidative stress is discussed in relation to reproductive and cardiovascular ageing. Premature ageing is associated with both low and high glucocorticoid function. Both over and undernutrition have offspring sex‐specific programming effects on life‐course glucocorticoid concentrations. Evidence is provided that maternal age at conception affects offspring endocrine and metabolism ageing. Finally, the importance of matching foetal nutrition and energy availability with composition and energy content in the post‐weaning diet is demonstrated. This mismatch can lead to a greatly shortened lifespan. General principles are discussed throughout. For example, sexual dimorphism of age‐related outcomes can be marked. Accelerated ageing occurs early in life. Improving knowledge on programming ageing interactions will improve health span as well as lifespan. Finally, there are considerable similarities in outcomes programmed by maternal undernutrition and overnutrition.
Charcot–Marie–Tooth disease misdiagnosed as chronic inflammatory demyelinating polyradiculoneuropathy: An international multicentric retrospective study
Authors: Hauw Fabien , Fargeot Guillaume , Adams David , Attarian Shahram , Cauquil Cécile , Chanson Jean‐Baptiste , Créange Alain , Gendre Thierry , Deiva Kumaran , Delmont Emilien , Francou Bruno , Genestet Steeve , Kuntzer Thierry , Latour Philippe , Le Masson Gwendal , Magy Laurent , Nardin Clotilde , Ochsner François , Sole Guilhem , Stojkovic Tanya , Maisonobe Thierry , Tard Céline , Van den Berghe Peter , Echaniz‐Laguna Andoni 
Published: June 2021

AbstractBackground and purposeCharcot–Marie–Tooth (CMT) disease, an untreatable hereditary polyneuropathy, may mimic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), a treatable neuropathy.MethodsIn this retrospective study, we analyzed the characteristics of CMT patients misdiagnosed as CIDP at 16 university hospitals in three countries, compared these patients with a reference group of CIDP patients, and estimated the cost of misdiagnosis.ResultsAmong 1104 CIDP cases, we identified 35 CMT patients misdiagnosed as CIDP (3.2%). All were initially diagnosed with definite or probable CIDP (European Federation of Neurological Societies/Peripheral Nerve Society criteria), and mutations in PMP22, MPZ, and 10 other CMT genes were found in 34%, 31%, and 35% of cases, respectively. In comparison with a reference group of 35 CIDP patients, CMT patients were younger (median age at disease onset = 39 vs. 56 years) and more frequently had motor weakness at disease onset (80% vs. 29%), hearing loss (14% vs. 0%), normal brachial plexus imaging (70% vs. 40%), lower cerebrospinal fluid protein content (median = 0.5 vs. 0.8 g/L), and lower treatment response (20% vs. 69%). Treatment cost in these 35 misdiagnosed patients was estimated at 4.6 million euros (M€), whereas the cost of CMT genetic analysis in 1104 patients was estimated at 2.7 M€.ConclusionsIn this study, 35 of 1104 (3.2%) patients initially diagnosed with CIDP had CMT. Importantly, the cost of treating these 35 misdiagnosed patients was significantly higher than the cost of performing CMT genetic analysis in 1104 patients (4.6 M€ vs. 2.7 M€), suggesting that CMT genetic investigations should be more widely used before diagnosing CIDP.