bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbid Anxiety and Depression and Related Factors Among Pregnant and Postpartum Chinese Women During the Coronavirus Disease 2019 Pandemic
Authors: Luo Zheng , Xue Luyao , Ma Li , Liu Zhengkui 
Published: October 2021

Objective: To identify the prevalence of comorbid anxiety and depression (CAD) and analyze the relationship between CAD and sociodemographic and obstetric-related variables in pregnant and postpartum Chinese women during the COVID-19 pandemic.Methods: Participants were 2,237 pregnant and postpartum women (aged 19–47 years) who visited various medical institutions in China between February 28, 2020, and April 26, 2020. They were asked to complete an online survey assessing the anxiety and depression, obstetric characteristics, and sociodemographic variables. The women were grouped into the following categories in accordance with the Generalized Anxiety Disorder Scale-7 (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9): (a) CAD, (b) “anxiety only,” (c) “depression only,” and (d) “no depression or anxiety.” After estimating the prevalence of CAD, “anxiety only,” and “depression only,” we carried out chi-squared tests and multiple logistic regression analysis to examine the related factors between these groups of pregnant and postpartum Chinese women.Results: Comorbid anxiety and depression, “anxiety only,” and “depression only,” occurred in 6.3, 5.8, and 3.9% of participants, respectively. The prevalence rates of CAD during the first, second, and third trimesters of pregnancy and the postpartum period were found to be 7.4, 6.5, 5.7, and 8.2%, respectively. The factors that differed among the groups were age (p &lt; 0.05), marital status (p &lt; 0.001), level of education (p &lt; 0.05), family support (p &lt; 0.001), and total live births (p &lt; 0.001). “Poor family support” (odds ratio (OR): 1.90; 95% confidence interval (CI): 1.30–2.78; p = 0.0009) and “no birth” (OR: 1.91; 95% CI: 1.32–2.75; p = 0.0006) remained significant factors for the CAD group, while “poor family support” (OR: 2.16; 95% CI: 1.34–3.47; p = 0.0015) remained a significant factor for the “depression only” group when their results were compared to those of the “no depression or anxiety” group in the multiple logistic regression analysis.Conclusion: Pregnant and postpartum Chinese women with poor family support and primipara are at high risk for CAD during the COVID-19 pandemic. These results support the need for targeted perinatal programs to address CAD in pregnant and postpartum women during the pandemic period.
Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors
Authors: Shaldam Moataz , Nocentini Alessio , Elsayed Zainab M. , Ibrahim Tamer M. , Salem Rofaida , El-Domany Ramadan A. , Capasso Clemente , Supuran Claudiu T. , Eldehna Wagdy M. 
Published: October 2021

A new series of quinoline-based benzenesulfonamides (QBS) were developed as potential carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4-anilinoquinoline scaffold where the primary sulphonamide functionality was grafted at C4 of the anilino moiety as a zinc anchoring group (QBS 13a–c); thereafter, the sulphonamide group was switched to ortho- and meta-positions to afford regioisomers 9a–d and 11a–g. Moreover, a linker elongation approach was adopted where the amino linker was replaced by a hydrazide one to afford QBS 16. All the described QBS have been synthesized and investigated for their CA inhibitory action against hCA I, II, IX and XII. In general, para-sulphonamide derivatives 13a–c displayed the best inhibitory activity against both cancer-related isoforms hCA IX (KIs = 25.8, 5.5 and 18.6 nM, respectively) and hCA XII (KIs = 9.8, 13.2 and 8.7 nM, respectively), beside the excellent hCA IX inhibitory activity exerted by meta-sulphonamide derivative 11c (KI = 8.4 nM). The most promising QBS were further evaluated for their anticancer and pro-apoptotic activities on two cancer cell lines (MDA-MB-231 and MCF-7). In addition, molecular docking simulation studies were applied to justify the acquired CA inhibitory action of the target QBS.
Parasite Prevalence May Drive the Biotic Impoverishment of New England (USA) Bumble Bee Communities
Authors: Averill Anne L. , Couto Andrea V. , Andersen Jeremy C. , Elkinton Joseph S. 
Published: October 2021

Numerous studies have reported a diversity of stressors that may explain continental-scale declines in populations of native pollinators, particularly those in the genus Bombus. However, there has been little focus on the identification of the local-scale dynamics that may structure currently impoverished Bombus communities. For example, the historically diverse coastal-zone communities of New England (USA) now comprise only a few species and are primarily dominated by a single species, B. impatiens. To better understand the local-scale factors that might be influencing this change in community structure, we examined differences in the presence of parasites in different species of Bombus collected in coastal-zone communities. Our results indicate that Bombus species that are in decline in this region were more likely to harbor parasites than are B. impatiens populations, which were more likely to be parasite-free and to harbor fewer intense infections or co-infections. The contrasting parasite burden between co-occurring winners and losers in this community may impact the endgame of asymmetric contests among species competing for dwindling resources. We suggest that under changing climate and landscape conditions, increasing domination of communities by healthy, synanthropic Bombus species (such as B. impatiens) may be another factor hastening the further erosion of bumble bee diversity.
Molecular Characterization and Taxonomic Assignment of Three Phage Isolates from a Collection Infecting Pseudomonas syringae pv. actinidiae and P. syringae pv. phaseolicola from Northern Italy
Authors: Martino Gabriele , Holtappels Dominique , Vallino Marta , Chiapello Marco , Turina Massimo , Lavigne Rob , Wagemans Jeroen , Ciuffo Marina 
Published: October 2021

Bacterial kiwifruit vine disease (Pseudomonas syringae pv. actinidiae, Psa) and halo blight of bean (P. syringae pv. phaseolicola, Pph) are routinely treated with copper, leading to environmental pollution and bacterial copper resistance. An alternative sustainable control method could be based on bacteriophages, as phage biocontrol offers high specificity and does not result in the spread of toxic residues into the environment or the food chain. In this research, specific phages suitable for phage-based biocontrol strategies effective against Psa and Pph were isolated and characterized. In total, sixteen lytic Pph phage isolates and seven lytic Psa phage isolates were isolated from soil in Piedmont and Veneto in northern Italy. Genome characterization of fifteen selected phages revealed that the isolated Pph phages were highly similar and could be considered as isolates of a novel species, whereas the isolated Psa phages grouped into four distinct clades, two of which represent putative novel species. No lysogeny-, virulence- or toxin-related genes were found in four phages, making them suitable for potential biocontrol purposes. A partial biological characterization including a host range analysis was performed on a representative subset of these isolates. This analysis was a prerequisite to assess their efficacy in greenhouse and in field trials, using different delivery strategies.
Terapia Assistida por Animais: relato das atividades com idosos do Projeto Cão-Cidadão-Unesp.
Authors: Da Silva Natália Canevassi , Pinho Renata Haddad , Lucas Flávia de Almeida , Souza Oliva Valéria Nobre Leal de 
Published: October 2021

Relata-se a experiência do projeto Cão-Cidadão-Unesp demonstrando os benefícios alcançados por meio da Terapia Assistida por Animais (TAA) em idosos institucionalizados na cidade de cidade de Araçatuba, São Paulo. O projeto atua em tal instituição há oito anos e o presente relato refere-se às observações realizadas durante o ano de 2014. Pode-se perceber que a presença dos cães contribuiu para uma maior qualidade de vida dos idosos.DOI: http://dx.doi.org/10.35700/ca.2016.ano3n4.p128-131.1821
Peran Pesantren Modern dalam Pembentukan Karakter Kepemimpinan Santri
Authors: Katon Gusti , Diany Saivy Ilma , Sulistyono Ro'id Naufal , Bachruddin Firman , Fatmawati  
Published: October 2021

Artikel ini hendak melihat cara bagaimana peran dari pesantren modern dalam membentuk karakter kepemimpinan santri-santrinya. Seperti diketahui banyak lembaga-lembaga pendidikan di Indonesia khususnya pondok pesantren modern memiliki strategi sendiri dalam membentuk karakter kepemimpinan santrinya. Pembentukan karakter santri ini nantinya akan berdampak pada alumni yg dihasilkan. Banyak alumni dari pesantren modern yang menjadi seorang pemimpin yang berkarakter yang telah memberikan banyak manfaat serta kontribusi pada masyarakat. Sehingga kami tergerak untuk menulis artikel ini untuk ingin mengetahui lebih dalam terkait bagaimana pesantren modern dalam membentuk karakter kepemimpinan santri. Penelitian ini menggunakan metode kajian literatur (pustaka) terhadap sumber-sumber yang relevan terkait judul mengenai “Peran Pesantren Modern dalam Pembentukan Karakter Kepemimpinan Santri”. Demi terbentuknya pemimpin yang berkarakter, pesantren modern bukan hanya me-manage, teach dan lead secara parsial. Melainkan total mendidikkan kehidupan secara utuh dan melibatkan dirinya dengan berbekal iman, ilmu, amal, akhlaq, komunikasi/interaksi dan mental yang tangguh. Sehingga terlahir pemimpin yang harus menguasai permasalahan, selalu banyak mengambil inisiatif, tidak menunggu diperintah, mampu menciptakan pekerjaan dan tidak mencari pekerjaan.
Kata kunci: karakter kepemimpinan, pesantren modern, santri
Abstract
This article is about to see how the role of modern pesantren in shaping the character of Santri-santrinya leadership. As many institutions in Indonesia are known, especially modern boarding schools have their own strategy in shaping the character of its Santrinya leadership. The creation of the students will later impact on the alumni who produced. Many alumni of modern pesantren have become a character leader who has given many benefits and contributions to the community. So we are moved to write this article to want to know more in the related how modern pesantren in shaping the character of students leadership. This study used the literature study method (libraries) on relevant sources related to the title of the role of Modern Pesantren in the formation of the character of the leadership of Santri. For the sake of the creation of character leaders, modern pesantren not only manage, teach and lead in a partial manner. Malainkan total lives the whole life and involves itself armed with faith, science, charity, Akhlaq, communication/interaction and a tough mental. So born leaders who have to master the problem, always many take the initiative, do not wait to be ruled, able to create jobs and do not find a job.
Penerapan Contextual Teaching and Learning (CTL) pada Pembelajaran Tematik Kelas IV-B Madrasah Ibtidaiyah Negeri 6 Jember
Authors: Efendi Arfan , Muhith Abdul 
Published: October 2021

2013 curriculum is a must thematic learning applied in elementary, this is because the basic thematic learning is explained in Attachment to the Minister of Education Regulation No. 67 of 2013 concerning the Basic Framework and Curriculum Structure of Elementary Schools / Islamic Elementary School that for the learning process at the elementary levels from grade 1 to grade VI uses integrated thematic learning. Thematic learning in application needs to use appropriate methods in its application so that learning objectives can be accepted by students. Learning methods with Contextual Teaching and Learning become an appropriate alternative when paired with thematic learning. The focus of research in this thesis is How is the Implementation of Planning, Implementation and Evaluation of Contextual Teaching and Learning (CTL) in Thematic Learning Class IV-B Islamic Elementary School Negeri 6 Jember Academic Year 2019/2020 ?. This study aims to Explain the Implementation of Contextual Teaching and Learning (CTL) Planning, Implementation in Thematic Learning Class IV-B Islamic Elementary School 6 Jember Academic Year 2019/2020. This study uses a qualitative approach to the type of descriptive research. In determining the research subject using Purposive Sampling and using data collection techniques through observation, interviews and documentation.

Kurikulum 2013 menjadi keharusan pembelajaran tematik diterapkan di SD/MI, hal ini dikarenakan dasar pembelajran tematik dijelaskan dalam Lampiran Permendikbud RI No. 67 Tahun 2013 tentang Kerangka Dasar dan Struktur Kurikulum Sekolah Dasar/ Madrasah Ibtidaiyah bahwa untuk proses pembelajaran pada jenjang SD/MI dari kelas 1 hingga kelas VI menggunakan pembelajaran tematik terpadu. Pembelajaran tematik dalam penerapan perlu menggunakan metode-metode yang tepat dalam penerapannya agar maksud pembelajaran dapat di terima oleh siswa. Metode pembelajaran dengan Contextual Teaching And Learning menjadi alternatif yang tepat bila di padukan dengan pembelajaran tematik. Fokus penelitian dalam skripsi ini adalah Bagaimana Penerapan Perencanaan, Pelaksanaan dan Evaluasi Contextual Teaching and Learning (CTL) pada Pembelajaran Tematik Kelas IV-B Madrasah Ibtidaiyah Negeri 6 Jember Tahun Pelajaran 2019/2020?. Penelitian ini bertujuan untuk Menjelaskan Penerapan Perencanaan, Pelaksanaan dan Evaluasi Contextual Teaching and Learning (CTL) pada Pembelajaran Tematik Kelas IV-B Madrasah Ibtidaiyah Negeri 6 Jember Tahun Pelajaran 2019/2020. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif. Dalam penentuan subjek penelitian menggunakan Purposive Sampling serta menggunakan teknik pengumpulan data melalui observasi, wawancara dan dokumentasi.
Kata Kunci: contextual teaching and learning, tematik, madrasah ibtidaiyah
Analisis Pembelajaran Daring terhadap Kejenuhan Belajar Mahasiswa Tadris Biologi IAIN Jember di Tengah Pandemi Covid-19
Authors: Pawicara Ruci , Conilie Maharani 
Published: October 2021

Online learning policies during the COVID-19 pandemic are the main solution to keeping the learning process going. But in the implementation, there are obstacles and flaws. The purpose of this study is to analyze the boredom learning toward biological students at IAIN Jember amid the COVID-19 pandemic. This research used the descriptive qualitative method with in-depth analysis. The results this study indicate the biological students at IAIN Jember experience learning burnout due to various factors indicated by several symptoms of learning burnout.

Kebijakan pembelajaran daring selama pandemi COVID-19 menjadi solusi utama agar proses pembelajaran tetap dapat berlangsung. Namun dalam pelaksanaannya terdapat kendala dan kekurangan. Tujuan dari penelitian ini adalah untuk menganalisis pembelajaran daring terhadap kejenuhan belajar mahasiswa Tadris Biologi IAIN Jember ditengah pandemi COVID-19. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif kualiatif menggunakan analisis secara mendalam. Hasil penelitian ini menunjukkan bahwa mahasiswa mengalami kejenuhan belajar dikarenakan berbagai faktor yang ditunjukkan oleh beberapa gejala kejenuhan belajar.
Kata kunci: kejenuhan belajar, pandemi COVID-19, pembelajaran daring
Hubungan Pengetahuan Lingkungan terhadap Sikap dan Perilaku Peduli Lingkungan pada Siswa SMAN 5 Jember Tahun Pelajaran 2018/2019
Authors: Agustin Evita Erryc , Maisyaroh Wiwin 
Published: October 2021

SMAN 5 Jember is a school that has received the Adiwiyata program predicate. Based on the phenomenon, students who have environmental knowledge do not necessarily have attitudes and behaviors that care about the environment. This is not in line with the school's goal of maintaining the status of a Adiwiyata school. The purpose of this study was to determine the relationship between environmental knowledge and environmental care and environmental care behavior among students of SMAN 5 Jember in the 2018-2019 academic year. This study uses a nonexperimental correlational quantitative approach using the ex post facto method. The population in this study were students of class X and XI, amounting to 480 students. The sampling technique used was proportionate stratified random sampling technique. Methods of data collection using observation, interviews, questionnaires and documentation. Data analysis used Kendall's Tau Correlation. Based on the results of the research on the relationship between environmental knowledge and environmental care attitudes in students of SMAN 5 Jember, the results obtained were 0.000 < 0.05 so that Ha was accepted and H0 was rejected, meaning that there was a significant relationship. The relationship between environmental knowledge and environmental care behavior results in 0.532> 0.05 so that Ha is accepted and H0 is rejected, meaning that there is no significant relationship.
Keywords: Adiwiyata, Knowledge, Attitude, and Behavior

SMAN 5 Jember merupakan sekolah yang mendapatkan predikat program Adiwiyata. Berdasarkan fenomena siswa yang memiliki pengetahuan lingkungan belum tentu memiliki sikap dan perilaku peduli lingkungan. Hal ini tidak selaras dengan tujuan sekolah mempertahankan status sekolah Adiwiyata. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan lingkungan dengan sikap peduli lingkungan dan perilaku peduli lingkungan pada siswa SMAN 5 Jember tahun pelajaran 2018-2019. Penelitian ini menggunakan pendekatan kuantitatif korelasional non eksperimental menggunakan metode ex post facto. Populasi pada penelitian ini yaitu siswa kelas X dan XIyang berjumlah 480 siswa. Teknik pengambilan sampel dengan menggunakan teknik sampling proportionate stratified random sampling. Metode pengumpulan data menggunakan observasi, wawancara, angket dan dokumentasi. Analisis data menggunakan Kendall’s Tau Correlation. Berdasarkan hasil penelitian hubungan pengetahuan lingkungan dengan sikap peduli lingkungan pada siswa SMAN 5 Jember diperoleh hasil 0,000 < 0,05 sehingga Ha diterima dan H0 ditolak artinya ada hubungan yang signifikan. Hubungan pengetahuan lingkungan dengan perilaku peduli lingkungan diperoleh hasil 0,532 > 0,05 sehingga Ha diterima dan H0 ditolak artinya tidak ada hubungan yang signifikan.
Kata kunci: Adiwiyata, Pengetahuan, Sikap, dan Perilaku
Manajemen Kegiatan Ekstrakurikuler dalam Pembentukan Karakter Religius Peserta Didik di MI Unggulan Riyadlul Qori’in Ajung Jember
Authors: Hamdani Musleh , Aminah Siti 
Published: October 2021

Extracurricular activities are activities that are carried out outside school, whether inside or outside the school with a view to enricing and broadening knowledge and ability of those students from the field of study already have. Madrasah Ibtidaiyah Riyadlul Qori'in Ajung Jember is one of the schools that have attention to the character issues of each student student. The study used a qualitative, descriptive approach lacated in premier MI Riyadlul Qori’in Ajung Jember. Collecting data in this study were observation, interview and documentation. The method of analysis in this study was the interactive descriptive analysis of Miles and Hubermans. The validity of data used was triangulation. The result of this study was (1) extracurricular activities planning to establish the religious character of each student, (2) the practice of the learning process was performed by the tutors and learners starting from the beginning of the opening to the conclusion, (3) assessments of activities wrere conducted every two weeks within the sumative assessment criteria, where the pass or no learner was known through the assessment.

Kegiatan Ekstrakurikuler merupakan kegiatan yang dilakukan di luar jam sekolah, baik yang dilakukan di dalam atau di luar sekolah dengan tujuan untuk memperkaya dan memperluas wawasan pengetahuan dan kemampuan yang telah dimiliki oleh peserta didik dari berbagai bidang studi. Madrasah Ibtidaiyah Riyadlul Qori’in Ajung Jember adalah salah satu sekolah yang memiliki perhatian terhadap masalah karakter setiap peserta didiknya. Penelitian ini menggunakan pendekatan kualitatif jenis deskriptif. Lokasi peneltian ini adalah MI Riyadlul Qori’in Ajung Jember. Data dalam penelitian ini dengan menggunakan metode observasi, wawancara dan dokumentasi. Metode analisis dalam penelitian ini adalah analisis deskriptif interaktif model Miles dan Huberman. Keabsahan data menggunakan triangulasi sumber dan metode. Hasil penelitian ini adalah (1) perencanaan kegiatan ekstrakurikuler bertujuan untuk membentuk karakter religius setiap peserta didik, (2) pelaksanaan proses pembelajaran dilakukan oleh tutor dan peserta didik yakni dimulai dari awal pembukaan sampai penutup, dan (3) evaluasi kegiatan dilakukan setiap dua minggu sekali dalam kriteria penilaian sumatif, dimana lulus atau tidaknya peserta didik diketahui melalui penilaian tersebut.
Kata kunci: manajemen kegiatan ekstrakurikuler, pembentukan karakter religius peserta didik
Agarwood Branch Ethanolic Extract Affects Expression of Apoptotic Genes in MCF-7 Breast Cancer Cells
Authors: Abbas Phirdaous , Samsudin Nurhusna , Ishak Nur Iffah , Mohd Salleh Hamzah , Syed Abd. Azziz Saripah Salbiah , Al-Khatib Ma'an Fahmi Rashid , Hashim Yumi Zuhanis Has-Yun 
Published: October 2021

Breast cancer is one of the most common death causes among women worldwide. Treatment is usually associated with chemically synthesized drugs with serious side effects which shifted the attention of cancer researchers towards development of natural product alternatives. Ethnopharmaceutical evidence showed that Aquilaria spp. have been used to treat a wide range of disorders. However, scientific evidence is still lacking to support and extend the traditional applications to cancer. This study aims to investigate differential gene expression (DEG) of MCF-7 cells treated with agarwood branch ethanolic extract (ABEE) to provide insights into its cell growth-inhibiting effects. Methods: cDNA synthesis from RNA of MCF-7 cells treated with the 8 µg/ml ABEE and DMSO-treated cells (control), respectively, were subjected to RT2 Profiler Array Human Cell Death Finder™ containing 84 genes related to cell death mechanism. Pathway analysis was carried out using the online KEGG Pathway tool. Results: 48 genes that met the threshold fold regulation cut-off of 2 and p < 0.05; 41 DEGs from the list were down-regulated, and 7 were up-regulated. Pathway analysis suggested ABEE may have caused apoptosis of MCF-7 cells through extrinsic and/or intrinsic apoptotic pathways, including activation of p53 that could be the first step towards apoptotic elimination of the cancer cells upon treatment of ABEE. Conclusion: Results obtained supported the growth inhibition effects of ABEE against MCF-7 cells that can serve as the basis for further work towards extending the use of agarwood as cancer therapeutics.