bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limitierende Faktoren für den Douglasienanbau in Mitteleuropa im Klimawandel
Authors: Schüler Silvio , Chakraborty Debojyoti 
Published: March 2021

Limitierende Faktoren für den Douglasienanbau in Mitteleuropa im Klimawandel
Die Douglasie ist eine der erfolgreichsten nicht heimischen Baumarten in Europa und wird im Klimawandel als wichtige alternative Wirtschaftsbaumart angesehen. Der Erfolg ihres zukünftigen Anbaus in Mitteleuropa hängt vom Verständnis ihrer klimatischen Nische und von der Berücksichtigung standörtlicher Gefährdungen ab. Der derzeitige Anbauschwerpunkt liegt grossteils in tieferen Lagen und reicht von klimatisch atlantisch bis zu kontinental geprägten Standorten. Baumartenverbreitungsmodelle zur Abschätzung der generellen klimatischen Eignung zeigen, dass bei steigenden Temperaturen viele der heutigen Standorte potenziell gefährdet sind und sich stattdessen zusätzliche Anbaugebiete in mittleren und höheren Lagen ergeben werden. Die bereits heute bekannten standörtlichen Risiken des Douglasienanbaus, zu denen das Auftreten von Früh- und Spätfrösten, die Frosttrocknis, ungeeignete Böden und die Douglasienschütte gehören, werden auch in Zukunft einen Einfluss auf die Bestandesentwicklung haben und dürften teilweise sogar zunehmen. Daher müssen bei einem verstärkten Anbau die standörtlichen Gegebenheiten beachtet und Douglasien aus geeigneten Herkünften verwendet werden. Stark frostgefährdete Lagen in Mulden und Tälern sollten vermieden werden, und kleinflächige Pflanzungen sind gegenüber grossflächigen Pflanzungen auf offener Fläche zu bevorzugen. Unterhänge sowie Standorte mit hoher Luftfeuchtigkeit und häaufigen Nebeln sind aufgrund ihrer Neigung zu Schütteinfektionen für den Douglasienanbau ungeeignet. In der Bewirtschaftung senken rechtzeitige und kräftige Durchforstungen das Infektionsrisiko und tragen zu gesunden und wüchsigen Douglasienbeständen bei. Obwohl einfache Klimavergleiche eine bessere Eignung der Inlanddouglasie nahelegen, kann diese aufgrund ihres frühen Austriebs, der hohen Schütteanfälligkeit und des geringen Wachstums in Mitteleuropa heute und in Zukunft nicht empfohlen werden. Langfristig sollten stattdessen Herkünfte aus dem südlichen Oregon und aus Kalifornien geprüft werden, um die bewährten Herkünfte aus den Samenzonen in Oregon und Washington zu ergänzen.
MEMOTIVASI MASYARAKAT UNTUK MENANAM POHON DALAM MENDUKUNG TERBENTUKNYA KOTA HIJAUDI KELURAHAN SUKAMULYA KECAMATAN SEMATANG BORANG KOTA PALEMBANG
Authors: Rosianty Yuli , Lensari Delfy , Syachroni Sasua Hustati 
Published: March 2021

Peningkatan laju pembangunan kota dan peningkatan juumlah penduduk menyebabkan berbagai aktifitas perkotaan juga meningkat seperti aktifitas pabrik dan kendaraan bermotor yang mengeluarkan gas CO2 yang merupakan salah satu gas rumah kaca penyumbang terbesar peningkatan pemanasan global. Untuk mengatasi permasalahan tersebut salah satu diantaranya adalah penanaman pohon sebagai RTH kota baik RTH publik maupun RTH private. Pengembangan RTH akan mendukung program pembangunan kota hijau. Maka diperlukan penyuluhan untuk menumbuhkan kesadaran masyarakat akan pentingnya peranan hutan dalam mengurangi polusi udara kota sehingga akan tumbuh minar masyarakat untuk menanam pohon di sekitar rumah atau lingkungan mereka.
ANALISIS BAURAN PEMASARAN DAN ANALISIS SWOT PENGEMBANGAN PARIWISATA ALAM TAMAN NASIONAL SEMBILANG
Authors: Kriswandi Budy , Sosilawati Endang 
Published: March 2021

Pengembangan obyek wisata direncanakan dan dilakukan sesuai dengan potensi dan kemampuan untuk menyusun rencana dan pengelolaan secara optimal sesuai dengan sumber daya yang dimiliki. Penelitian ini bertujuan untuk mengetahui dan menganalisis strategi pengembangan pemasaran dan strategi pengembangan objek wisata Taman Nasional Sembilang dalam menarik wisatawan. Penelitian dilaksanakan dari bulan Oktober 2014 sampai Januari 2015 di Instansi Balai Taman Nasional Sembilang. Penelitian ini menggunakan data primer dan sekunder. Hasil penelitian menunjukkan bahwa aspek yang sudah dalam keadaaan baik menurut bauran pemasaran adalah Customer Service (3,11), sedangkan aspek Produk (2,75), Harga (2,19), Promosi (2,63), Tempat (2,34), People (2,96), Proses (2,49) merupakan aspek-aspek yang masih butuh perbaikan ke depannya. Berdasarkan analisis SWOT didapatkan hasil bahwa saat ini Taman Nasional Sembilang termasuk pada posisi mendukung strategi agresif (kuadran 1). Hal ini dapat diartikan bahwa Taman Nasional Sembilang dalam kondisi prima dan mantap sehingga sangat memungkinkan untuk terus melakukan ekspansi, memperbesar pertumbuhan dan meraih kemajuan secara optimal. Oleh karena itu, strategi yang ditawarkan dari hasil penelitian ini adalah perpaduan antara kekuatan dan peluang atau strategi Strength-Opportunitis (SO) yang dapat diartikan bahwa Taman Nasional Sembilang dapat memanfaatkan seluruh kekuatan untuk merebut dan memanfaatkan peluang sebesar-besarnya.
Correlation between Fitness Parameters and An Occupational Rescue Simulation among Emergency Care Providers in North West Province, South Africa: A Pilot Study
Authors: Mthombeni Solomon , Coopoo Yoga , Noorbhai Habib 
Published: March 2021

Objective The purpose of the study was to examine the relationship between validated fitness parameters and an emergency rescue simulation (RS) circuit performed by emergency care providers (ECPs). Methods A cross-sectional study was selected to determine the relationship between the fitness tests and the RS. Twenty ECPs in the North West province of South Africa participated in the study. Demographic data were collected, followed by testing of anthropometric characteristics and field fitness tests measuring muscular strength, muscular endurance, aerobic capacity, anaerobic capacity and flexibility. Thereafter, participants had to complete a RS circuit. Pearson's correlation coefficient was used to assess the relationship between variables. Differences in age, gender and body mass index formed part of the descriptive statistics. A test-retest reliability method was applied to evaluate the reliability of the RS. Results Significant correlations were found between the RS and the 250 m shuttle run (r=0.83; p<0.01), flexed-arm hang test (r=-0.59; p<0.01), Cooper 12-minute test (r=-0.56; p<0.01), and the maximum push-up test (r=-0.51; p<0.05). Conclusion Findings demonstrate a possible association between aerobic capacity, anaerobic capacity, muscular strength, muscular endurance and ECP performance in an occupational task-related RS. Improved performance in these specific fitness areas may enable ECPs to be better prepared for the physical demands of their occupation. The RS may also be used as a tool to assess job (physical) preparedness of qualified ECPs during their recruitment, but this requires further validation.
Fuzzy pairwise regular bitopological spaces in quasi-coincidence sense
Authors: Amin Md Ruhul , Hossain Md Sahadat , Miah Saikh Shahjahan 
Published: March 2021

This paper introduces three notions of fuzzy pairwise regular between bitopological spaces in quasi-coincidence sense. Then, we investigate some relations between ours and other counterparts. We observe that all these concepts are preserved under one-one, onto, fuzzy closed, fuzzy open, and fuzzy continuous mappings. Also, the hereditary property is satisfied by these concepts.
Journal of Bangladesh Academy of Sciences, Vol. 44, No. 2, 139-143, 2020
A experiência do puerpério para as famílias: revisão integrativa
Authors: Silva Fernanda Rios da , Lacerda Maria Ribeiro , Gomes Ingrid Meireles , Denipote Adelita Gonzalez Martinez , Teruya Luciana Midori 
Published: March 2021

Objetivo: sistematizar as evidências disponíveis na literatura sobre a experiência do puerpério para as famílias. Metodologia: revisão integrativa nas bases: Medical Literature Analysis and Retrieval System Online, Cumulative Index to Nursing & Allied Health Literature, Web of Science, Scopus, Scientific Electronic Library Online e ScienceDirect e na Biblioteca Virtual de Saúde. Nas bases e portal pesquisados, foram feitos cruzamentos utilizando os descritores e palavras-chaves: famílias, relacionamento familiar, relação familiar, dinâmica familiar, período pós-parto, puerpério, pós-parto da mulher, habitação, domicílio, domiciliar, doméstico, apartamento, apartamentos, casa, casas, lar, lares, moradia, moradias, experência de vida, e acontecimentos que mudam a vida. Resultados: a amostra foi constituída por oito artigos que apresentaram valores culturais repassados de uma geração para outra, que influenciam a família na criação de novos membros; a melhoria das relações familiares através da prática de exercícios físicos pelas puérperas; o uso de mídias sociais e das ferramentas: Modelo Calgary de Avaliação da Família, Modelo Calgary de Intervenção Familiar e Newborn Behavioral Observation, para apoiar a prática profissional baseada em evidências. Considerações finais: as transições no ciclo da vida, embora façam parte do processo de desenvolvimento familiar, em geral são acompanhadas por conflitos marcantes. As transformações ocorridas no puerpério, especificamente, afetam a dinâmica familiar, requerendo dos profissionais de saúde, sobretudo das enfermeiras, suporte para a adaptação à nova realidade.
New-generative agriculture â€“ based on science, informed by research and honed by New Zealand farmers
Authors: Rowarth Jacqueline , Manning Michael , Roberts Ants , King Warren 
Published: March 2021

Highlights

Regenerative agriculture is being promoted as a way to produce food sustainably while building soil carbon under high residual rotational grazing and minimising environmental impact.
Research indicates that the environmental impact of conventional agricultural systems is generally lower than for alternative systems per unit of food production and sometimes per hectare. Soil carbon is higher under well-managed intensive grazing than under extensively managed systems. Adopting non-optimal grazing management decreases pasture quality and increases GHG and N losses.
New Zealand has developed optimal rotational grazing and has soils with high organic-matter contents. Rather than adopting a concept developed overseas which has a fluid definition, New Zealand could promote New-generative agricultureâ€¦ encapsulating what is already being done.
Prostate-Specific Membrane Antigen (PSMA) Promotes Angiogenesis of Glioblastoma Through Interacting With ITGB4 and Regulating NF-κB Signaling Pathway
Authors: Gao Yang , Zheng Hui , Li Liangdong , Feng Mingtao , Chen Xin , Hao Bin , Lv Zhongwei , Zhou Xiaoyan , Cao Yiqun 
Published: March 2021

BackgroundGlioblastoma multiforme (GBM) is the most common primary malignant tumor in the central nervous system (CNS), causing the extremely poor prognosis. Combining the role of angiogenesis in tumor progression and the role of prostate-specific membrane antigen (PSMA) in angiogenesis, this study aims to explore the functions of PSMA in GBM.MethodsClinical GBM specimens were collected from 60 patients who accepted surgical treatment in Fudan University Shanghai Cancer Center between January 2018 and June 2019. Immunohistochemical staining was used to detect PSMA and CD31 expression in GBM tissues. Prognostic significance of PSMA was evaluated by bioinformatics. Human umbilical vein endothelial cells (HUVECs) transfected with PSMA overexpression plasmids or cultured with conditioned medium collected based on GBM cells, were used for CCK8, Transwell and tube formation assays. High-throughput sequencing and immunoprecipitation were used to explore the underlying mechanism. Furthermore, the in vivo experiment had been also conducted.ResultsWe demonstrated that PSMA was abundantly expressed in endothelium of vessels of GBM tissues but not in vessels of normal tissues, which was significantly correlated with poor prognosis. Overexpression of PSMA could promotes proliferation, invasion and tube formation ability of human umbilical vein endothelial cells (HUVECs). Moreover, U87 or U251 conditioned medium could upregulated PSMA expression and induce similar effects on phenotypes of HUVECs, all of which could be partially attenuated by 2-PMPA treatment. The mechanistic study revealed that PSMA might promote angiogenesis of GBM through interacting with Integrin β4 (ITGB4) and activating NF-κB signaling pathway. The in vivo growth of GBM could be alleviated by the treatment of 2-PMPA.ConclusionThis study identified PSMA as a critical regulator in angiogenesis and progression of GBM, which might be a promising therapeutic target for GBM treatment.
Autosomal Recessive Rod-Cone Dystrophy Associated With Compound Heterozygous Variants in ARL3 Gene
Authors: Fu Leming , Li Ya , Yao Shun , Guo Qingge , You Ya , Zhu Xianjun , Lei Bo 
Published: March 2021

Purpose:ARL3 (ADP-ribosylation factor-like 3) variants cause autosomal dominant retinitis pigmentosa (RP) or autosomal recessive Joubert syndrome. We found a family with rod-cone dystrophy (RCD) and verified it was associated with compound heterozygous variants in ARL3 gene.Methods: Ophthalmic examinations including optical coherence tomography and electroretinogram (ERG) were performed. Targeted next generation sequencing (NGS) was performed for the proband using a custom designed panel. Sanger sequencing and co-segregation were conducted in the family members. Changes of protein structure mediated by the variants were studied in vitro. ARL3 protein stability and its interaction with RP2 protein were assessed by cycloheximide chase assay and co-immunoprecipitation (Co-IP) assay.Results: Visual acuity of the 18-year-old male proband was 0.25 in the right and 0.20 in the left eye, while his non-consanguineous parents and sister was normal. The proband showed signs of RCD, including nyctalopia, peripheral field loss, bone-spicule deposits in the retina, and reduced ERG responses. The father, aged 50 years old, showed visual acuity of 1.0 in both eyes. Unlike the proband, he presented late onset and mild cone-rod dystrophy (CRD), including macular atrophy, central scotomata, moderate reduction in photopic ERG responses. None of all the family members had hearing abnormality, mental dysplasia or gait instability. We identified two novel compound heterozygous variants (c.91A&gt;G, p.T31A; c.353G&gt;T, p.C118F) in ARL3 in the proband, while his father only had variant c.91A&gt;G. Bioinformatics analysis indicated amino acid positions of the two variants are highly conserved among species. The in silico tools predicted the variants to be harmful. Protein structure analysis showed the two variants had potential to alter the protein structure. Based on the ACMG guidelines, the two variants were likely pathogenic. In addition, the ARL3 mutations destabilized ARL3 protein, and the mutation c.353G&gt;T disrupted the interaction between ARL3 and RP2 in HEK293T cells.Conclusions: We showed novel compound heterozygous variants in ARL3 were associated with early onset of autosomal recessive RCD, while c.91A&gt;G along may be associated with a late onset of dominant CRD. The two variants in ARL3 could be causative by destabilizing ARL3 protein and impairing its interaction with RP2 protein.
The Impact of Gut Microbiome on Metabolic Disorders During Catch-Up Growth in Small-for-Gestational-Age
Authors: An Jingjing , Wang Junqi , Guo Li , Xiao Yuan , Lu Wenli , Li Lin , Chen Lifen , Wang Xinqiong , Dong Zhiya 
Published: March 2021

ObjectiveCatch-up growth (CUG) in small for gestational age (SGA) leads to increased risk of metabolic syndrome and cardiovascular diseases in adults. It remains unclear if microbiota could play an important role in CUG-SGA independent of genetic or nutritional factors. The present study explored the role of gut microbiota in, and its association with, metabolic disorders during CUG-SGA.MethodsAn SGA rat model was established by restricting food intake during pregnancy, and the rats were divided into catch-up growth (CUG-SGA) and non-catch-up growth (NCUG-SGA) groups based on body weight and length at the fourth postnatal week. High-throughput sequencing of 16S rRNA was conducted to detect the diversity and composition of the gut microbiota. Fecal short-chain fatty acids (SCFAs) were detected by gas chromatography-mass spectrometry. Transcriptome sequencing of liver tissue was performed and verified using real-time PCR. Concentrations of insulin and total cholesterol were determined using enzyme-linked immunosorbent assay.ResultsThe composition of gut microbiota in CUG-SGA rats differed from that of NCUG-SGA rats, with reduced abundance of Lactobacillus in the CUG-SGA group. The decrease in Lactobacillus was significantly associated with increased body weight and upregulated insulin and total cholesterol levels. Five SCFAs and two branched chain fatty acids were significantly higher in the CUG-SGA group than in the NCUG-SGA group. Additionally, SCFAs were positively associated with clinical indices such as weight, body mass index, insulin, and total cholesterol. Transcriptomic data revealed that insulin-like growth factor-2 expression was significantly decreased in CUG-SGA rats and was associated with a decrease in Lactobacillus bacteria.ConclusionLactobacillus and SCFAs were associated with the metabolic disorders during CUG in SGA. Gut microbiome may play a certain role on metabolic disorders during catch-up growth in small-for-gestational-age.
Case Report: A Novel PAX3 Mutation Associated With Waardenburg Syndrome Type 1
Authors: Hu Qiuming , Ma Huazhong , Shen Jiawei , Zhuang Zongming , Li Jianqiang , Huang Xinlan , Li Xian , Li Haoyu 
Published: March 2021

Background: Waardenburg Syndrome Type 1 (WS1) is a rare hereditary disease, which is usually caused by the mutations of PAX3 (paired box 3). Here, we reported a pedigree with WS1, which was caused by a novel mutation in PAX3.Case Report: In this present report, a 10-year-old boy and his twin sister from a Han Chinese family presented with iris pigmentary abnormality, synophrys, and broad and high nasal root. Their father presented premature whitening of the hair, but no iris pigmentary abnormality. Their aunts presented the same clinical characteristics with the twins and premature graying of hair. However, none of the patients reported hearing loss. The clinical diagnosis of the four patients from this pedigree was WS1. The whole exome sequencing (WES) revealed a novel mutation (c.959-5T&gt;G) in the PAX3 gene, which could be responsible for the observed pathogenic of WS1 in this pedigree. The genetic test confirmed the diagnosis of WS1 in the four patients from the studied pedigree.Conclusion: This present study demonstrated that genetic test based on WES, an effective alternative to regular clinical examinations, helps diagnose WS1. The newly identified PAX3 gene mutation can expand the understanding of WS1.
Modulation of Liver Inflammation and Fibrosis by Interleukin-37
Authors: Mountford Steffeni , Effenberger Maria , Noll-Puchta Heidi , Griessmair Lucas , Ringleb Andrea , Haas Sonja , Denk Gerald , Reiter Florian P. , Mayr Doris , Dinarello Charles A. , Tilg Herbert , Bufler Philip 
Published: March 2021

Background and Aims: Chronic inflammation induces liver fibrosis, cirrhosis and potentially liver cancer. Kupffer cells modulate hepatic stellate cells by secreting immunologically active proteins as TGF-β. TGF-β promotes liver fibrosis via the activation of Sma- and Mad-related protein 3. IL-37 broadly suppresses innate and adaptive immune responses. Intracellular IL-37 interacts with Smad3. We hypothesize that IL-37 downregulates the activation of hepatic Kupffer and stellate cells and interferes with the TGF-β signaling cascade to modulate liver fibrogenesis.Methods: The role of IL-37 on liver inflammation and fibrogenesis was assessed in three mouse models as well as isolated Kupffer- and stellate cells. Serum IL-37 was tested by ELISA in a clinical cohort and correlated with liver disease severity.Results: Transgene expression of IL-37 in mice extends survival, reduces hepatic damage, expression of early markers of fibrosis and histologically assessed liver fibrosis after bile duct ligation. IL-37tg mice were protected against CCl4-induced liver inflammation. Colitis-associated liver inflammation and fibrosis was less severe in IL-10 knockout IL-37tg mice. Spontaneous and LPS/TGF-β-induced cytokine release and profibrogenic gene expression was lower in HSC and KC isolated from IL-37tg mice and IL-37 overexpressing, IL-1β stimulated human LX-2 stellate cells. However, administration of recombinant human IL-37 did not modulate fibrosis pathways after BDL in mice, LX2 cells or murine HSCs. In a large clinical cohort, we observed a positive correlation of serum IL-37 levels with disease severity in liver cirrhosis.Conclusions: Predominantly intracellular IL-37 downregulates liver inflammation and fibrosis. The correlation of serum IL-37 with disease severity in cirrhosis suggests its potential as a novel target modulating the course of liver fibrosis.
Effects of a 4-Step Standard Operating Procedure for the Treatment of Fever in Patients With Acute Stroke
Authors: Lee Hanna , Hedtmann Günter , Schwab Stefan , Kollmar Rainer 
Published: March 2021

Background and Purpose: Fever in the acute phase of stroke leads to an unfavorable clinical outcome and increased mortality. However, no specific form of effective fever treatment has been established, so far. We analyzed the effectiveness of our in-house standard operating procedure (SOP) of fever treatment.Methods: This SOP was analyzed for a period of 33 weeks. Patients with cerebral ischemia (ischemic stroke, transient ischemic attack) or cerebral hemorrhage (intracerebral, subarachnoid) and body temperature elevation of ≥ 37.5°C within the first 6 days after admission were eligible for inclusion in the analysis. The results of SOP group, who's data have been collected prospectively were then compared with a historical control group that had been treated conventionally 1 year earlier in the same period. The data of control group have been collected in retrospect. The primary endpoint was the total duration of the fever for the first 6 days after admission to the stroke unit.Results: A total of 130 patients (mean age of 78 ± 12) received 370 antipyretic interventions. Sequential application of paracetamol (n = 245), metamizole (n = 53) and calf compress (n = 15) led to significant reduction in body temperature. In patients who did not respond to these applications, normothermia could be achieved after infusion of the cooled saline solution. Normothermia could be achieved within 120 min in more than 90% of the cases treated by the SOP. The SOP reduced the fever duration in the 6 days significantly, from 12.2 ± 2.7 h [95% confidence interval (CI) for mean] in the control group to 3.9 ± 1.0 h (95% CI) in the SOP group (p &lt; 0.001). The SOP was rated to be reasonable and effective.Conclusion: Our in-house SOP is cost-efficient and effective for fever treatment in stroke patients, that can be implemented by local health care professionals.