bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular hemodynamics and blood pressure differences between young and older women
Authors: Ballenger Brantley K. , Hunter Gary R. , Fisher Gordon 
Published: November 2021

Abstract
Background
Cardiovascular disease is one of the main causes of death in the United States, and hypertension is a primary risk factor. Therefore, the primary causes of hypertension need to be identified so they may be addressed for treatment. The purpose of this study was to compare blood pressure with hemodynamic values and identify factors that may explain blood pressure differences between a cohort of healthy normotensive younger and older women.

Methods
Participants were 49 young (age: 33.8 ± 5.9) and 103 old (age: 65.8 ± 4) who were non-hypertensive, had no previous history of heart disease or type 2 diabetes, body mass index less than 30 kg/m2, normal electrocardiography response at rest and during exercise, nonsmokers, and no use of medications known to affect cardiovascular or metabolic function. Body composition measured by dual-energy X-ray absorptiometry. Hemodynamic values measured by non-invasive pulse wave velocity through radial artery tonometry. Markers of inflammation measured through blood sample analysis.

Results
Significant differences exist between young and old groups in %fat (P < 0.001), systolic blood pressure (SBP) (P = 0.001), large artery elasticity (P = 0.005), small artery elasticity (P < 0.001), systemic vascular resistance (P = 0.004), total vascular impedance (P < 0.001), estimated cardiac output (P < 0.001), and tumor necrosis factor-⍺ (TNF-⍺) (P < 0.001). Using ANCOVA the difference in SBP between age groups was no longer significant after adjusting for small artery elasticity (P < 0.001) and TNF-⍺ (P = 0.041).

Conclusions
These data demonstrate that blood pressure and vascular hemodynamic measures differ significantly between young and old women independent of body composition. Furthermore, these differences may be explained by the inflammation marker TNF-⍺ and/or small artery elasticity.
Tritium labeling of antisense oligonucleotides via different conjugation agents
Authors: Edelmann Martin R. , Husser Christophe , Duschmalé Martina B. , Fischer Guy , Senn Claudia , Koller Erich , Brink Andreas 
Published: November 2021

AbstractA novel approach to tritium-labeled antisense oligonucleotides (ASO) was established by conjugating N-succinimidyl propionate, as well as maleimide-derivatives, to the 3′-end of ASOs targeting metastasis-associated lung adenocarcinoma transcript 1 (Malat1) containing amino- or sulfhydryl-linkers. In vitro stability and Malat1 RNA reduction studies demonstrated that N-ethylmaleimide (NEM) could be used as a stable tag while maintaining the desired target interaction. The corresponding radioactive label conjugation using [3H]-NEM resulted in tritium-labeled ASOs with a high molar specific activity of up to 17 Ci/mmol. Single-dose in vivo studies in mice were carried out to compare [3H]-ASOs with their unlabeled counterpart ASOs, with and without conjugation to N-acetylgalactosamine (GalNAc), for tissue and plasma concentrations time profiles. Despite the structural modification of the labeled ASOs, in vitro target interaction and in vivo pharmacokinetic behaviors were similar to that of the unlabeled ASOs. In conclusion, this new method provides a powerful technique for fast and safe access to tritium-labeled oligonucleotides, e.g., for pharmacokinetic, mass balance, or autoradiography studies.
Graphical abstract
Performance of ENMC and EULAR/ACR classification systems applied to a single tertiary center cohort of dermatomyositis patients
Authors: Zoske Jan , Schneider Udo , Siegert Elise , Kleefeld Felix , Preuße Corinna , Stenzel Werner , Hahn Katrin 
Published: November 2021

Abstract
Background
There have been numerous classification systems to diagnose corresponding myositis subtypes and select appropriate therapeutic measures. However, the lack of a broad consensus on diagnostic criteria has led to clinical uncertainties. The objective of this study was to compare two commonly used dermatomyositis-classification systems regarding their clinical practicability and to point out their specific advantages and disadvantages.

Methods
This study included 30 patients diagnosed with dermatomyositis at the Charité university hospital, Berlin, Germany from 2010 to 2017. Patient files with complete data and defined historical classifications were enrolled and ENMC (2003) and EULAR/ACR (2017) criteria retrospectively applied.

Results
According to the ENMC approach, 14 patients were classified as "definite" and 12 as "probable" dermatomyositis. One patient exhibited an "amyopathic dermatomyositis" and three a "DM without dermatitis". Regarding the criteria probability of the EULAR/ACR set, 16 patients had a "high", 13 a "medium" and one a "low probability". There was a significant difference (p = 0.004) between the subclasses of the ENMC in relation to the EULAR/ACR score. The agreement between the classification probabilities of "definite/high" (κ = 0.400) and "possible/medium" (κ = 0.324) was fair.

Conclusions
It is important to find a consensus among the medical disciplines involved and to establish a structured procedure. Future studies with newer approaches are warranted to conclusively decide which system to use for the physician.
Facile and scalable preparation of ZIF-67 decorated cotton fibers as recoverable and efficient adsorbents for removal of malachite green
Authors: Li Linhua , Yang Lin , Zou Rui , Lan Jianwu , Shang Jiaojiao , Dou Baojie , Liu Hongyu , Lin Shaojian 
Published: November 2021

AbstractRecently, metal–organic frameworks (MOFs) have received considerable attention as highly efficient adsorbents for dye wastewater remediation. However, the immobilization of MOFs on the substrate surfaces to fabricate easy recyclable adsorbents via a facile route is still a challenge. In this work, ZIF-67/cotton fibers as adsorbents for dye removal were prepared in a large-scale using a simple coordination replication method. The successful fabrication of the ZIF-67/cotton fibers was confirmed by FTIR, XRD, XPS, SEM and BET analysis, respectively. As expected, the as-prepared ZIF-67/cotton fibers exhibited high adsorption capacity of 3787 mg/g towards malachite green (MG). Meanwhile, the adsorption kinetics and isotherm obeyed the pseudo-second-order kinetics and Langmuir model, respectively. Moreover, its removal efficiency towards MG was not significantly influenced by the pH and ionic strength of aqueous solution. Most importantly, the ZIF-67/cotton fibers can remove MG from synthetic effluents, and it can be easily regenerated without filtration or centrifugation processes, with the regeneration efficiency remaining over 90% even after 10 cycles. Additionally, the ZIF-67/cotton fibers presented excellent antimicrobial performance against E. coli and S. aureus. Hence, the distinctive features of the as-prepared ZIF-67/cotton fibers make it promisingly applicable for the colored wastewater treatment.
Quantitative extraction of chromium VI and III from tanned leather: a comparative study of pretreatment methods
Authors: Arellano-Sánchez Mónica Gisel , Devouge-Boyer Christine , Hubert-Roux Marie , Afonso Carlos , Mignot Mélanie 
Published: November 2021

AbstractIn this study, seven pretreatment methods for chromium speciation in tanned leather were evaluated: acidic mineralization, ethylenediaminetetraacetic acid (EDTA) extraction, diethylenetriaminepentaacetic acid (DTPA) extraction, alkaline extraction (NH4OH), ammonium nitrate extraction (NH4NO3), water extraction, and phosphate buffer extraction. Acidic mineralization permitted the decomposition of the organic matter and ensured the complete digestion of leathers, giving access to the total content of chromium in each sample using inductively coupled plasma-atomic emission spectrometry (ICP-AES). From all the extractant media tested, EDTA proved to be the most efficient, allowing the extraction of Cr(VI) and Cr(III) as a Cr(III)-EDTA complex, quantitatively. Method validation is presented for EDTA extraction and direct mineralization. For the EDTA extraction, method detection limit (MDL) and method quantification limit (MQL) for total Cr in leather were 3.4 ppb and 11.2 ppb (µg of total Cr per L of extraction solution), respectively. Due to the lack of leather certified reference materials (CRMs) for Cr(VI), accuracy was evaluated by spiking leather samples with a Cr(VI) solution. The spike recovery of EDTA microwave assisted extraction ranged from 91.0 to 108.6%. Interday precision was also evaluated and all variation coefficients were below 5%, for both mineralization and EDTA extraction. This article provides an efficient procedure to extract quantitatively chromium from leather, while maintaining the speciation, which can be further followed by ion chromatography-inductively coupled plasma-mass spectrometry (IC-ICP-MS).
Stroke, spinal cord ischemia and upper limb ischemia in patients undergoing TEVAR with coverage of the left subclavian artery: a case series study
Authors: Rizk Mohamed Abd El-Monem Abd El-Salam , Ismail Mohamed Ismail Mohamed , Gohar Kareem Sabry 
Published: November 2021

Abstract
Background
We performed routine spinal fluid drainage for patients who underwent TEVAR for thoracic aortic pathology together with left subclavian artery coverage, which was needed for achievement of a safe proximal sealing zone. We assessed the occurrence of spinal cord ischemia as well the rate of occurrence of other complications such as stroke, and upper limb ischemia.

Results
This was a case series study done between July 2014 and April 2020, in them all the left subclavian artery was covered to ensure a proximal safe seal zone. Routine spinal fluid drainage was done, keeping the spinal fluid pressure < 10–15 mmHg with catheter in place for 48 h. Data was obtained from twenty-three patients who underwent TEVAR for thoracic aortic dissection (73.91%), thoracic aortic aneurysm (21.74%), or ulcer (4.35%). Planning was based upon multi-slice computed tomographic angiography and covering the left subclavian was mandatory to achieve a proximal sealing zone. Technical success was achieved in 100% of cases. 4.35% of patients had three endograft, 56.52% had two endografts, 39.13% had one endograft. All patients lost their radial pulsations immediately after implantation, 8.70% developed post implantation syndrome(fever) that was managed conservatively, 4.35% developed stroke related to the anterior circulation, 4.35% developed signs of spinal cord ischemia. During the follow up, one patient died within 6 h after the procedure due to extensive myocardial infarction (patient was scheduled for CABG after our procedure). 17.40% developed upper limb symptoms that were tolerable and were managed conservatively.

Conclusion
By adopting routine spinal cord drainage and pressure monitoring, we can consider not to revascularize the left subclavian artery prior to TEVAR if it will be covered.
FDG-PET/CT in predicting aggressiveness of rectal cancer
Authors: Ahmed Iman Sherif , El Gaafary Saher Mohamed , Elia Remon Zaher , Hussein Rasha S. 
Published: November 2021

Abstract
Background
Treatment response varies significantly among rectal cancer patients. Tumor can show complete regression, stationary appearance, or even tumour progression during the treatment. It is also widely known that the rate of local recurrence is variable. Precise risk stratification of tumor aggressiveness is required for better per patient tailored treatment plan and predicting the overall prognosis of rectal cancer patients The aim of this study was to assess different parameters of baseline [18F] fluorodeoxyglucose positron emission tomography/computed tomography [(18F) FDG-PET/CT] as a non-invasive tool in predicting aggressiveness of the rectal cancer.

Results
Overall, 33 patients were included [19 moderately differentiated adenocarcinoma, 10 poorly differentiated adenocarcinoma and 4 mucinous adenocarcinomas (MAC)]. SUV estimates (SUV max, SUV mean) were greater in the moderately adenocarcinoma group (p = 0.003 and p = 0.019, respectively). MTV and TLG values were similar between the three histopathological groups (p = 0.763 and p = 0.701, respectively). There was no correlation between SUVmax of primary tumor and MTV (r = 0.034; p = 0.849). However, SUVmax and TLG were significantly correlated (r = 0.517; p = 0.002). Strong correlation between tumor size and MTV (r = 0.489; p = 0.003), and TLG (r = 0.506; p = 0.003) were observed. No significant association was found between MTV and TLG and the clinical stage of rectal cancer.

Conclusion
Baseline 18F-FDG PET/CT parameters cannot be used alone as a non-invasive diagnostic technique in assessing aggressiveness and prognosis in patients with primary rectal cancer, and further clinical studies are needed before considering the prognostic role of FDG-PET/CT in rectal cancer.
Diagnostic accuracy of internal jugular vein ultrasound in quantification of the central venous pressure for hemodialysis patients
Authors: Baz Ahmed Abd Alrahman , Ibrahim Amro Abdulrahim , El-Fishawy Hussein Saeed , Al-Bohy Abo El-Magd Mohamed 
Published: November 2021

Abstract
Background
Assessment of the central venous pressure (CVP) is an essential hemodynamic parameter for monitoring the dialyzing patients. Our objective of the present study is to investigate the accuracy of CVP measurement by internal jugular vein US in comparison to the direct measurement by the central venous catheters for hemodialysis patients. We included 106 patients; where their CVP was assessed in two different non invasive US methods (CVPni) separately and in combination and the obtained measurements were correlated to the invasive measurements (CVPi) by catheters.

Results
By method 1, there is a highly significant positive correlation between CVPni and CVPi (ρ < 0.001) and a Pearson correlation coefficient (r = 0.913 n = 93), and by method 2, there is also a highly significant positive correlation between the CVPni and CVPi in both groups (r = 0.832, 95%, n = 106, p < 0.001), 1.935 was the cut-off point for prediction of CVP ≥ 10cmH20. For differentiation between patients with CVP < 10cmH20 and ≥ 10cmH20, the accuracy measures (sensitivity, specificity, PPV, NPV, and overall accuracy) were 100%, 79.31%, 74.47%, 100%, and 87.10% by method 1, and were 91.11%, 85.48%, 82.00%, 92.98%, and 87.85% by method 2, while the combination of both methods had gained 88.57%, 89.66%, 83.78%, 92.86%, and 89.25%, respectively.

Conclusion
The US offered a reliable and non-invasive tool for monitoring CVP. The present study has a novelty of combining more than one US method and this had reported higher accuracy measures and outperformed the use of a single method.
Natural variant frequencies across domains from different sarcomere proteins cross-correlate to identify inter-protein contacts associated with cardiac muscle function and disease
Authors: Burghardt Thomas P. 
Published: November 2021

AbstractCoordinated sarcomere proteins produce contraction force for muscle shortening. In human ventriculum they include the cardiac myosin motor (βmys), repetitively converting ATP free energy into work, and myosin binding protein C (MYBPC3) that in complex with βmys is regulatory. Single nucleotide variants (SNVs) causing hereditary heart diseases frequently target this protein pair. The βmys/MYBPC3 complex models a regulated motor and is used here to study how the proteins couple. SNVs in βmys or MYBPC3 survey human populations worldwide. Their protein expression modifies domain structure affecting phenotype and pathogenicity outcomes. When the SNV modified domain locates to inter-protein contacts it could affect complex coordination. Domains involved, one in βmys the other in MYBPC3, form coordinated domains (co-domains). Co-domain bilateral structure implies the possibility for a shared impact from SNV modification in either domain suggesting a correlated response to a common perturbation could identify their location. Genetic divergence over human populations is proposed to perturb SNV probability coupling that is detected by cross-correlation in 2D correlation genetics (2D-CG). SNV probability data and 2D-CG identify three critical sites, two in MYBPC3 with links to several domains across the βmys motor, and, one in βmys with links to the MYBPC3 regulatory domain. MYBPC3 sites are hinges sterically enabling regulatory interactions with βmys. The βmys site is the actin binding C-loop (residues 359-377). The C-loop is a trigger for actin-activated myosin ATPase and a contraction velocity modulator. Co-domain identification implies their spatial proximity suggesting a novel approach for in vivo protein complex structure determination.
Enabling quality of urban spaces in Cairo’s new suburban settlements: a community character approach for New Cairo, Egypt
Authors: Murshed Sally M. , Ouf Ahmed M. , Zafarany Abbas F. 
Published: November 2021

AbstractA global concern claims that activities and functions that once filled traditional public spaces are privatized being less and less oriented to the public. In Cairo’s new settlements, public spaces don’t seem to contribute to its public life. Each community’s most valuable assets are the ones they already have; thus, urbanisms advocate the role of retaining traditional street patterns, vistas, and landscape of a community’s distinct character. The research aim is to identify design attributes to be added to the literature in terms of designing public spaces for the specific cultural context of Cairo, Egypt, and its new suburban settlements. The methodology then follows a comparative analysis study to reach the desired objectives of buildings a community character approach. In an exploratory method, two case studies of public spaces in Cairo are chosen following a purposive selection most relevant to the study. The target is to choose two cases in proximity for users to be familiar with the two of them and enable a reliable comparison. It then conducts a survey that involves the user’s evaluation of their public spaces in correlation to their needs. Jan Gehl’s twelve criteria are adopted by this paper’s field investigation for the assessment of public spaces’ quality. Findings of the study include an elaboration on Jan Gehl’s twelve criteria either by highlighting the importance of existing aspects or the addition of further criteria that showed value to public space quality and their users. The findings provide guidelines that help in designing quality public spaces in Cairo’s new settlements. The added value from this study is in identifying a set of factors or attributes that consider users’ needs for a given cultural context.
Review of sheep and goat pox disease: current updates on epidemiology, diagnosis, prevention and control measures in Ethiopia
Authors: Zewdie Girma , Derese Getaw , Getachew Belayneh , Belay Hassen , Akalu Mirtneh 
Published: November 2021

AbstractSheep pox, goat pox, and lumpy skin diseases are economically significant and contagious viral diseases of sheep, goats and cattle, respectively, caused by the genus Capripoxvirus (CaPV) of the family Poxviridae. Currently, CaPV infection of small ruminants (sheep and goats) has been distributed widely and are prevalent in Central Africa, the Middle East, Europe and Asia. This disease poses challenges to food production and distribution, affecting rural livelihoods in most African countries, including Ethiopia. Transmission occurs mainly by direct or indirect contact with infected animals. They cause high morbidity (75-100% in endemic areas) and mortality (10-85%). Additionally, the mortality rate can approach 100% in susceptible animals. Diagnosis largely relies on clinical symptoms, confirmed by laboratory testing using real-time PCR, electron microscopy, virus isolation, serology and histology. Control and eradication of sheep pox virus (SPPV), goat pox virus (GTPV), and lumpy skin disease (LSDV) depend on timely recognition of disease eruption, vector control, and movement restriction. To date, attenuated vaccines originating from KSGPV O-180 strains are effective and widely used in Ethiopia to control CaPV throughout the country. This vaccine strain is clinically safe to control CaPV in small ruminants but not in cattle which may be associated with insufficient vaccination coverage and the production of low-quality vaccines.
Birth Spacing and Fertility in the Presence of Son Preference and Sex-Selective Abortions: India's Experience Over Four Decades
Authors: Pörtner Claus C. 
Published: November 2021

Abstract
Since the advent of prenatal sex-determination technologies in the mid-1980s, India has experienced an increasingly male-biased sex ratio at birth, presumably from sex-selective abortions. Abortions lengthen birth intervals, but we know little about how birth spacing has changed or the effects of these changes. I show that, although the overall length of birth intervals increased from 1970 to the mid-2010s, well-educated women with no sons had the most substantial lengthening, as well as the most male-biased sex ratios. Furthermore, most of these changes took place immediately after the introduction of prenatal sex-determination technologies. Consequently, some women without sons now have longer birth intervals than those with sons, reversing India's traditional spacing pattern. Women with low education continue short birth spacing when they have no sons, with only limited evidence of male-biased sex ratios. Because of the rapid lengthening of birth intervals, period fertility rates substantially overestimated how fast cohort fertility fell. Moreover, predicted cohort fertility is still 10%–20% above the period fertility rate. If the lengthening of birth intervals arises from repeated abortions, the associated short pregnancy spacing may counteract any positive effects of longer birth spacing. There is, however, no evidence of this effect on infant mortality. Judging from sex ratios, sex-selective abortion use is not declining.
Structural Heteropatriarchy and Birth Outcomes in the United States
Authors: Everett Bethany G. , Limburg Aubrey , Homan Patricia , Philbin Morgan M. 
Published: November 2021

Abstract
Emerging evidence links structural sexism and structural discrimination against lesbian, gay, and bisexual (LGB) populations to poor health outcomes, but studies have yet to examine the combined effects of these mutually reinforcing systems of inequality. Therefore, we developed a composite measure of structural heteropatriarchy—which includes state-level LGB policies, family planning policies, and indicators of structural sexism (e.g., women's political and economic position relative to men)—and examined its relationship to birth outcomes using data from Waves I to V of the National Longitudinal Study of Adolescent to Adult Health. Multivariate regression analyses demonstrated that higher levels of heteropatriarchy were associated with an increased risk of preterm birth and decreased birth weight, net of important covariates. There was no association between clinical low birth weight and heteropatriarchy, or interactions between heteropatriarchy and individuals' race, ethnicity or sexual identity, suggesting a negative effect of heteropatriarchy on birth outcomes for all pregnant people. This study demonstrates the importance of considering gender and sexuality as mutually reinforcing systems of oppression that impact population health. Future research should examine the impact of heteropatriarchy on additional health outcomes and in conjunction with other structural inequalities such as racism and transgender oppression.