bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rol del Instituto Nacional Materno Perinatal en la reducción de la mortalidad materna y neonatal
Authors: Guevara-Ríos Enrique 
Published: March 2021

El 10 de octubre de 1826 el Mariscal don Andrés de Santa Cruz, quien, por decreto supremo emitido por Hipólito Unanue, creó la Casa de Maternidad, centro hospitalario que tendría como finalidad la atención de las parturientas, donde además se impartiría preparación en la práctica obstétrica para la formación de comadronas instruidas y hábiles1.
En 1943, durante el primer gobierno de don Manuel Prado, por decreto supremo, se le da la denominación oficial de Hospital de Maternidad de Lima. En 2002 logra la denominación de Instituto Especializado Materno Perinatal y desde el 2006 es categorizado como Instituto Nacional Materno Perinatal 2.
La misión del INMP es brindar atención especializada a las mujeres, gestantes y recién nacidos de alto riesgo, desarrollando investigación, tecnologías y docencia a nivel nacional 3. En su rol de establecimiento de tercer nivel tiene como políticas 4: el acceso oportuno a los servicios altamente especializados en las mujeres en la atención de la salud sexual y reproductiva y acceso a las gestantes y recién nacidos en el área materno perinatal, contribuyendo a la formación de redes de servicios efectivas para la atención, con énfasis en la atención de alta complejidad; el fortalecimiento de la capacidad resolutiva para la alta complejidad de los principales hospitales del país con atención materno perinatal, mejorando las competencias del talento humano; y promover la docencia e investigación materna perinatal, el desarrollo de nuevas tecnologías, innovación y modelos de atención.
El INMP tiene como objetivo general Brindar atención altamente especializada y de calidad en salud sexual y reproductiva con énfasis en las gestantes y neonatos de alto riesgo que acudan al INMP y que sean referidas de otros establecimientos de salud de Lima y de todas las regiones del país. Sus objetivos específicos son:

Atención altamente especializada en obstetricia crítica, medicina materno-fetal, medicina reproductiva y en neonatología crítica.
Desarrollo del potencial humano de la institución, a nivel nacional e internacional.
Promoción de investigaciones que puedan contribuir a mejorar la salud de las mujeres, gestantes y neonatos en el país.
Keanekaragaman Koloni Mikroorganisme Rizosfer Lahan Tebu (Saccharum officinarum) Pada Penggunaan Pupuk Bio-Slurry dan Pupuk Kimia
Authors: Ismy Adifatul , Syauqi Ahmad , Zayadi Hasan 
Published: March 2021

The diversity of microorganisms is very important in the balance of soil ecosystems is also an indicator of soil health and can affect the condition of plants that grow on it. Rizosphere is a part of the soil around the root of a plant. The activity of some rhizosphere microorganisms plays a role in the nutrient cycle and the process of soil formation, plant growth, affecting microorganism activity, and as biological control of root pathogens. The research objective was to determine the value of the sugarcane (Saccharum officinarum) rhizosphere microorganism index using Bio-slurry and chemical fertilizers. This study uses descriptive explorative methods. The data analyzed in the form of measurement of pH, number of microorganism colonies and diversity index. Diversity of Colonies Rhizosphere microorganisms Sugarcane land that uses Bio-slurry and those using Chemical Fertilizer are classified as low respectively 0.47 and 0.69. Colony groups found in each land are bacteria and fungi.
Keywords: Diversity, Rizosphere, Saccharum officinarum, Bio-slurry, Chemical Fertilizers
ABSTRAK
Keanekaragaman mikroorganisme sangat penting dalam keseimbangan ekosistem tanah juga merupakan indikator kesehatan tanah dan dapat mempengaruhi kondisi tanaman yang tumbuh di atasnya. Rizosfer merupakan bagian tanah yang berada di sekitar perakaran tanaman. Aktivitas beberapa mikroorganisme rizosfer berperan dalam siklus hara dan proses pembentukan tanah, pertumbuhan tanaman, memengaruhi aktivitas mikroorganisme, serta sebagai pengendali hayati terhadap patogen akar. Penelitian ini bertujuan untuk mengetahui nilai indeks keanekaragaman mikroorganisme rizosfer tebu (Saccharum officinarum) yang menggunakan Bio-slurry dan pupuk kimia. Penelitian ini menggunakan metode diskriptif eksploratif. Data yang dianalisis berupa hasil pengukuran pH, jumlah koloni mikroorganisme dan indeks keragaman. Keanekaragaman koloni mikroorganisme rizosfer lahan tebu yang menggunakan Bio-slurry dan yang menggunakan Pupuk kimia tergolong rendah masing-masing bernilai 0,47 dan 0,69. Kelompok koloni mikroorganisme yang ditemukan pada masing-masing lahan yaitu bakteri dan jamur.
Kata kunci: Keanekaragaman, Rizosfer, Saccharum officinarum, Bio-slurry, Pupuk Kimia
Kepadatan Populasi Ikan Gelodok Di Hutan Mangrove Desa Penunggul Kecamatan Nguling Kabupaten Pasuruan
Authors: Basri Moch. Chasan , Santoso Hari , Laili Saimul 
Published: March 2021

Mangrove forests are the one of the coastal ecosystems; especially the northern coast and many are founded in the surrounding fish ecosystems. That organism is the one of the fauna which mangrove ecosystem constituent. The aim of this study was to determine the density and abundance of the population of Gelodok fish at mangrove areas in Penunggul Village, Nguling District. This study used a purposive sampling method from three stations and each station has three plots and three replications in each plot. The results showed that the density of frog fish in the mangrove forest area of ​​Nguling village at station 1 was 3 as well as at station 2 and 3 respectively 2 and 1. At station 1 there were three species, namely Baleopthalmus boddarti, Periopthalmus dipus, Periophthalmus Gracilis, station 2, there were two species; Baleopthalmus boddarti, Periophthalmus Gracilis, and station 3 there were three species namely Baleopthalmus boddarti, Periopthalmodon schlosseri, Periopthalmus dipus. The differences in the results of the study, environmental conditions and abiotic factors influence the density of fish in the mangrove area and at the station 1 the density is highe.
Keywords: Gelodok fish, mangrove forest, population
ABSTRAK
Hutan mangrove merupakan salah satu ekosistem daerah pantai terutama pantai utara dan banyak di temui ikan Gelodok di sekitar ekositem ini. Organisme tersebut merupakan salah satu fauna penyusun ekositem mangrove. Tujuan penelitian ini untuk mengetahui kepadatan dan kemelimpahan populasi ikan Gelodok kawasan mangrove desa Penunggul Kecamatan Nguling. Penelitian ini menggunakan metode purposive sampling dari tiga stasiun dan setiap stasiun terdapat tiga plot dengan ulangan tiga kali dalam setiap plot. Hasil penelitian menunjukkan bahwa kepadatan ikan gelodok di kawasan hutan mangrove desa Nguling rata-rata pada stasiun 1 adalah 3, di satsiun 2; 2 dan 3; 1. Pada stasiun 1 terdapat tiga spesies yaitu Baleopthalmus boddarti, Periopthalmus dipus, Periophthalmus Gracilis , stasiun 2 terdapat dua spesies yaitu Baleopthalmus boddarti, Periophthalmus Gracilis dan stasiun 3 terdapat tiga spesies yaitu Baleopthalmus boddarti, Periopthalmodon schlosseri, Periopthalmus dipus. Perbedaan hasil penelitian, kondisi lingkungan dan faktor abiotik mempengaruhi kepadatan ikan Gelodok di kawasan mangrove, sehingga pada stasiun 1 diperoleh kepadatan lebih tinggi.
Kata kunci: ikan Gelodok, hutan mangrove, kepadatan populasi
Pengaruh Fraksi Ejakulasi terhadap Motilitas Spermatozoa Kambing Peranakan Etawa (Capra aegagrus)
Authors: Nahdiyah Ayu Naila , Santoso Hari , Zayadi Hasan 
Published: March 2021

The ejaculation fraction on Etawa crossbred goat (PE goat) has various standard spermatozoa qualitues, one of which ismotility of spermatozoa. The motility of spermatozoa is very important to note in the development of artificial insemination techniques, because the success in artificial insemination techniques is strongly influenced by the motility of spermatozoa. The motility of semen spermatozoa is known through the process of examining the movement of spermatozoa in microscopic testing. The aim of this research was find out the effect of ejaculation fraction on motility of PE goat spermatozoa. Using an experimental method with a group's random consisting of two treatment groups; K1 is fraction 1and K2 is a fraction 2. The Replication of each treatment was eight replications and a total of sample research was 16 unit. The semen was collected once a week using artificial vagina (VA) technique. The semen collecting until the second ejaculation and motility test of spermatozoa were immediately measured use sperm vision analyzers IVOS II. The test results of the ejaculation fraction observation using an independent sample t-test showed the value of t hit = 0.700 and t (0.025) than 2.14 t hit <t (0.025) meaning that H0 was received, there was no significant ejaculation fraction 1 with ejaculatory fraction 2; motility meaning of the spermatozoa from the PE goat of a fraction 1 and faction 2 not different significantly.
Keywords: ejaculation fraction, motility of Spermatozoa, PE goat.
ABSTRAK
Fraksi Ejakulasi pada Kambing Peranakan Etawa (PE) mempunyai kualitas spermatozoa dengan berbagai standart, salah satunya motilitas spermatozoa. Motilitas Spermatozoa menjadi hal yang sangat penting untuk diperhatikan dalam pengembangan teknik Inseminasi Buatan, karena keberhasilan dalam teknik Inseminasi Buatan sangat dipengaruhi oleh motilitas yang dimiliki spermatozoa. Motilitas spermatozoa semen diketahui melalui proses pemeriksaan daya gerak spermatozoa dalam uji mikroskopis. Penelitian ini bertujuan untuk mengetahui pengaruh fraksi ejakulasi terhadap motilitas spermatozoa kambing PE. Menggunakan metode percobaan dengan rancangan acak kelompok (RAK) terdiri atas 2 kelompok perlakuan yakni Kelompok 1 (K1) adalah fraksi 1dan kelompok 2 (K2) adalah fraksi 2, ulangan masing-masing perlakuan 8 ulangan dan unit penelitian berjumlah 16. Penampungan semen dilakukan satu kali seminggu dengan teknik AV (Artificial Vagina). Penampungan dilakukan sampai ejakulat kedua. Segera setelah penampungan dilakukan pengukuran uji motilitas spermatozoa menggunakan sperm vision analyser IVOS II. Hasil uji pengamatan fraksi ejakulasi menggunakan t-test independent sample menunjukkan nilai t hit= 0,700 dan t (0,025)= 2,14 maka t hit < t (0,025) artinya H0 di terima, yang mempunyai arti motilitas spermatozoa kambing PE dari fraksi 1 dan fraksi 2 tidak berbeda nyata.
Kata kunci: fraksi ejakulasi, motilitas spermatozoa, kambing PE
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner
Authors: Chen Xiao-Yu , Liang Rui , Yi You-Cai , Fan Hui-Ning , Chen Ming , Zhang Jing , Zhu Jin-Shui 
Published: March 2021

ObjectivesN6-methyladenosine (m6A) RNA methylation is implicated in the progression of multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene in gastric cancer (GC), while the biological mechanisms via which YTHDF1 regulates gastric tumorigenesis through m6A modification remain largely unknown.MethodsGEO and TCGA cohorts were analyzed for differentially expressed m6A modification components in GC clinical specimens and their association with clinical prognosis. Transwell and flow cytometry assays as well as subcutaneous xenograft and lung metastasis models were used to evaluate the phenotype of YTHDF1 in GC. Intersection of RNA/MeRIP-seq, luciferase assay, RIP-PCR, RNA pull-down and MeRIP-PCR was used to identify YTHDF1- modified USP14 and its m6A levels in GC cells.ResultsHigh-expressed YTHDF1 was found in GC tissues and was related to poor prognosis, acting as an independent prognostic factor of poor survival in GC patients. YTHDF1 deficiency inhibited cell proliferation and invasion (in vitro), and gastric tumorigenesis and lung metastasis (in vivo) and also induced cell apoptosis. Intersection assays revealed that YTHDF1 promoted USP14 protein translation in an m6A-dependent manner. USP14 upregulation was positively correlated with YTHDF1 expression and indicated a poor prognosis in GC.ConclusionOur data suggested that m6A reader YTHDF1 facilitated tumorigenesis and metastasis of GC by promoting USP14 protein translation in an m6A-dependent manner and might provide a potential target for GC treatment.
Phase Angle Cut-Off Points and Their Association With Sarcopenia and Frailty in Adults of 50–64 Years Old and Older Adults in Mexico City
Authors: Rosas-Carrasco Oscar , Ruiz-Valenzuela Roxana E. , López-Teros Miriam T. 
Published: March 2021

Background: In recent studies, the usefulness of the phase angle (PA) to assess geriatric conditions such as sarcopenia and frailty has been evaluated. However, there are no useful cut-off points for clinical research and/or practice.Objective: To analyze PA cut-off points associated with sarcopenia and frailty in adults of 50-64 years old and older adults in Mexico City.Design: Cross-sectional analysis of the FraDySMex cohort study (Frailty, Dynapenia, and Sarcopenia in Mexican Adults).Setting and Participants: 498 people were included, 78.7% women, aged 71.1 ± 9.5 years. Methods: The sarcopenia measurements were made according to the European Working Group on Sarcopenia in Older People (EWGSOP) (2019) (by dynamometer to evaluate hand grip strength and dual energy X-ray absorptiometry (DXA) for appendicular muscle mass), and the frailty through the physical frailty phenotype with cut-off points adjusted to the Mexican population. The PA was evaluated by bioelectrical impedance analysis (BIA), tetrapolar to 50 Hz, other variables such as socio-demographic, comorbidity, cognitive status, and functional dependence were evaluated.Results: The prevalence of frailty was 10.6% and sarcopenia 10.0%. The mean of the PA was 4.6° ± 0.70°. The PA cut-off point for frailty in adults 50 to 64 years was ≤4.3° [sensitivity (S) = 91.95%, specificity (Sp) 66.77%, AUROC (Area Under the Receiver Operating Characteristic) curve = 0.9273 95% CI (0.8720-0.9825)]; the PA cut-off point for sarcopenia was ≤4.3 [S = 91.95%, Sp = 66.77%, AUROC = 0.9306 95% CI (0.8508-1.000)]. The PA cut-off for frailty in adults ≥ 65 years was ≤4.1° [S = 72.37%, Sp 71.43%, AUROC = 0.7925 95%, CI (0.7280-0.8568)] for sarcopenia was ≤4.1° [S = 72.76%, Sp 73.81%, AUROC = 0.7930 95% CI (0.7272-0.8587)]. These cut-off points showed a significant association between PA with frailty (OR 4.84; 95% CI 2.61-8.99) and sarcopenia (OR 8.44; 95% CI 3.85-18.4) after adjusted by age, sex, BMI, comorbidity index and cognitive impairment.Conclusions and Implications: These cut-off points of PA could be useful for the screening of sarcopenia and frailty in Mexican adults of 50 years and older in centers that have BIA.
Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study
Authors: Zhang Wenxiang , Fang Yi , Zhang Zhihui , Wang Jing 
Published: March 2021

ObjectiveThe purpose of our study was to analyze the clinicopathologic features and surgical and oncological outcomes of adenoid cystic carcinoma (ACC) of the breast and to provide the basis for a clinical therapeutic schedule.MethodsA total of 14 patients with primary breast adenoid cystic carcinoma treated at Cancer Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2017 were included. Data on clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed.ResultsFourteen patients were diagnosed with ACC of the breast, out of 23205 total patients treated for breast cancer (0.06%). All but three patients were postmenopausal, with a median age at diagnosis of 60.5 years (range, 39–73 years). The most common clinical presentation was a palpable mass (85.7%), and the imaging characteristics of all patients on color Doppler ultrasound and mammography were nonspecific. Six patients (42.9%) were suspected of having ACC by fine-needle aspiration cytology (FNAC) and were confirmed by postoperative histology and immunohistochemistry. All 14 patients underwent surgery, and no patient had a positive lymph node status. Median tumor size was 1.75 cm (range, 1–3 cm). Eight/14 (57.1%) patients were hormone receptor negative (HR−) and HER-2/neu (−) (HER2−). The remaining patients were hormone receptor positive (HR+). There was no significant difference in clinicopathological characteristics between the HR+ group and the HR- group (P&gt;0.05). The mean follow-up period was 57 months. Local recurrence occurred in 14.3% of patients, 1.7% of patients had distant metastasis, all patients with local recurrence or distant metastasis were in the HR (-) group, and all patients were alive at the last follow-up.ConclusionACC of the breast cannot be simply summarized as triple-negative breast cancer because it also includes a small number of hormone receptor-positive breast cancers. Establishing a preoperative diagnosis is difficult on the basis of clinical imaging examination, FNAC may be useful tool in the diagnosis. the final diagnosis can only be assessed based on the results of the histopathological and immunohistochemical examination. Breast-conserving surgery may be an alternative treatment strategy, and axillary lymph node dissection or sentinel node biopsy may not be necessary in some cases.
External Evaluation of Vancomycin Population Pharmacokinetic Models at Two Clinical Centers
Authors: Liu Yi-Xi , Wen Haini , Niu Wan-Jie , Li Jing-Jing , Li Zhi-Ling , Jiao Zheng 
Published: March 2021

Background: Numerous vancomycin population pharmacokinetic models in neonates have been published; however, their predictive performances remain unknown. This study aims to evaluate their external predictability and explore the factors that might affect model performance.Methods: Published population pharmacokinetic models in neonates were identified from the literature and evaluated using datasets from two clinical centers, including 171 neonates with a total of 319 measurements of vancomycin levels. Predictive performance was assessed by prediction- and simulation-based diagnostics and Bayesian forecasting. Furthermore, the effect of model structure and a number of identified covariates was also investigated.Results: Eighteen published pharmacokinetic models of vancomycin were identified after a systematic literature search. Using prediction-based diagnostics, no model had a median prediction error of ≤ ± 15%, a median absolute prediction error of ≤30%, and a percentage of prediction error that fell within ±30% of &gt;50%. A simulation-based visual predictive check of most models showed there were large deviations between observations and simulations. After Bayesian forecasting with one or two prior observations, the predicted performance improved significantly. Weight, age, and serum creatinine were identified as the most important covariates. Moreover, employing a maturation model based on weight and age as well as nonlinear model to incorporate serum creatinine level significantly improved predictive performance.Conclusion: The predictability of the pharmacokinetic models for vancomycin is closely related to the approach used for modeling covariates. Bayesian forecasting can significantly improve the predictive performance of models.
The Antiangiogenic Effect of Sanguinarine Chloride on Experimental Choroidal Neovacularization in Mice via Inhibiting Vascular Endothelial Growth Factor
Authors: Zhang Junxiu , Mao Ke , Gu Qing , Wu Xingwei 
Published: March 2021

Background: The purpose of this study is to investigate the antiangiogenic effect of Sanguinarine chloride (SC) on models of age-related macular degeneration (AMD) both in vivo and in vitro.Methods: Choroidal neovascularization (CNV) was conducted by laser photocoagulation in C57BL6/J mice. SC (2.5 μM, 2 μl/eye) was intravitreally injected immediately after laser injury. The control group received an equal amount of PBS. 7 days after laser injury, CNV severity was evaluated using fundus fluorescein angiography, hematoxylin and eosin (H&amp;E) staining, and choroid flat-mount staining. Vascular endothelial growth factor (VEGF) expression in the retina/choroid complex was measured by western blot analysis and ELISA kit. In vitro, human retinal microvascular endothelial cells (HRMECs) were used to investigate the effects of SC on cell tube formation, migration, and cytotoxicity. The expression of VEGF-induced expression of extracellular signal-regulated kinase (ERK)1/2, protein kinase B (AKT), mitogen-activated protein kinases (p38-MAPK) in vitro and laser induced VEGF expression in vivo were also analyzed.Results: SC (≤2.5 μM) was safe both in vitro and in vivo. Intravitreal injection of SC restrained the formation of laser induced CNV in mice and decreased VEGF expression in the laser site of the retina/choroid complex. In vitro, SC inhibited VEGF-induced tube formation and endothelial cell migration by decreasing the phosphorylation of AKT, ERK1/2, and p38-MAPK in HRMECs.Conclusions: SC could inhibit laser-induced CNV formation via down-regulating VEGF expression and restrain the VEGF-induced tube formation and endothelial migration. Therefore, SC could be a potential candidate for the treatment of wet AMD.
Sorbent based on modified hydrolysis lignin for the purification of wastewater from oil refineries
Authors: Гималетдинов Р.Р. , Усманов М.Р. , Валеев С.Ф. , Бодров В.В. , Паскару К.Г. , Вежновец В.П. 
Published: March 2021

Представлены результаты исследований применения сорбента «SynergySorb® ПС-1000» на основе модифицированного гидролизного лигнина для очистки сточных вод крупных нефтеперерабатывающих предприятий. За счет развитой системы микро- и мезопор сорбент эффективно поглощает легкие фракции углеводородов, снижая общее содержание нефтепродуктов в сточной воде и интенсивность запаха вблизи открытых очистных сооружений. Полная динамическая обменная емкость сорбента по нефтепродуктам составила 0,605 г/г при фильтрации сточных вод одного из крупных российских нефтеперерабатывающих заводов. Средняя эффективность очистки до проскока нефтепродуктов составила 94%, интенсивность запаха воды в результате испытаний снижена с 5 до 2 баллов. Отработанный сорбент «SynergySorb® ПС-1000» относится к 4 классу опасности (малоопасный) по показателям токсичности и экотоксичности
The results of studies of using SynergySorb® PS-1000 sorbent based on modified hydrolysis lignin for the purification of wastewater from large oil refineries are presented. Owing to the developed system of micro- and mesopores, the sorbent effectively absorbs light fractions of hydrocarbons, thus reducing the total content of oil products in wastewater and the intensity of odor near open treatment facilities. The total dynamic exchange capacity of the sorbent for oil products was 0.605 g/g while filtering wastewater from one of the largest Russian oil refineries. The average treatment efficiency before the breakthrough of oil products was 94%, the intensity of effluent odor as a result of tests was reduced from 5 to 2 points. Spent SynergySorb® PS-1000 sorbent belongs to the 4th hazard class (low hazard) in terms of toxicity and ecotoxicity.