bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antipsychotics increase steroidogenic enzyme gene expression in the rat brainstem
Authors: Bogus Katarzyna , Żarczyńska Małgorzata , Pałasz Artur , Suszka-Świtek Aleksandra , Worthington John J. , Krzystanek Marek , Żarczyński Piotr 
Published: November 2021

Abstract
Background
Neurosteroids are involved in several important brain functions and have recently been considered novel players in the mechanic actions of neuropsychiatric drugs. There are no reports of murine studies focusing on the effect of chronic neurosteroid treatment in parallel with antipsychotics on key steroidogenic enzyme expression and we therefore focused on steroidogenic enzyme gene expression in the brainstem of rats chronically treated with olanzapine and haloperidol.

Methods and results
Studies were carried out on adult, male Sprague–Dawley rats which were divided into 3 groups: control and experimental animals treated with olanzapine or haloperidol. Total mRNA was isolated from homogenized brainstem samples for RealTime-PCR to estimate gene expression of related aromatase, 3β-HSD and P450scc. Long-term treatment with the selected antipsychotics was reflected in the modulation of steroidogenic enzyme gene expression in the examined brainstem region; with both olanzapine and haloperidol increasing aromatase, 3β-HSD and P450scc gene expression.

Conclusions
The present findings shed new light on the pharmacology of antipsychotics and suggest the existence of possible regulatory interplay between neuroleptic action and steroidogenesis at the level of brainstem neuronal centres.
Sustainability considerations in remediation, retrofit, and seismic upgrading of historic masonry structures
Authors: Corradi Marco , Mustafaraj Enea , Speranzini Emanuela 
Published: November 2021

AbstractThis paper addresses the problem of sustainability in remediation, retrofit, and seismic upgrading of historic masonry structures. Different rehabilitation techniques and some successful applications throughout the Balkans and Italy are described, with particular emphasis to the shear reinforcement of wall panels. The selected techniques aim at improving the seismic performance, preserving the structures for future generations, having the least impact in altering the architectural and heritage values, as well as being sustainable, in terms of reduced carbon dioxide emissions, reversibility, and low energy consumption. The use of cross-laminated timber (CLT), natural fibers, and fiber-reinforced Polymers (FRP) jacketing with natural lime coatings are discussed. The paper concludes by summarizing key successes of the proposed rehabilitation solutions in conservation engineering and suggests areas in which these could be used with great advantage.
A Through-Process Experimental Approach to Enable Optimization of Cold Sprayed Al 7075 Consolidation Performance
Authors: Tsaknopoulos Kyle , Sousa Bryer , Massar Christopher , Grubbs Jack , Siopis Mathew , Cote Danielle 
Published: November 2021

AbstractThis work employs an example of a through process experiment systematic approach to study the relationship among powder properties, cold spray (CS) processing parameters, and consolidated specimen behavior through a combined effort of characterization methods and computational models. This process will allow for the systematic isolation of variables that can affect powder and CS deposit properties. In this study, Al 7075 powder was used as feedstock to produce a CS coating using industry-standard processing parameters. Techniques such as SEM, EDS, XRD, nanoindentation, and tensile testing were used to characterize the properties of both the feedstock powder and CS deposits. In addition, computational thermodynamic modeling was used to guide the interpretation of microstructural features of the powder and CS specimen. Finally, an additive yield strength model was employed to quantify the strengthening components introduced through the CS process.
Improving bounds on probabilistic affine tests to estimate the nonlinearity of Boolean functions
Authors: Sălăgean Ana , Stănică Pantelimon 
Published: November 2021

AbstractIn this paper we want to estimate the nonlinearity of Boolean functions, by probabilistic methods, when it is computationally very expensive, or perhaps not feasible to compute the full Walsh transform (which is the case for almost all functions in a larger number of variables, say more than 30). Firstly, we significantly improve upon the bounds of Zhang and Zheng (1999) on the probabilities of failure of affinity tests based on nonhomomorphicity, in particular, we prove a new lower bound that we have previously conjectured. This new lower bound generalizes the one of Bellare et al. (IEEE Trans. Inf. Theory 42(6), 1781–1795 1996) to nonhomomorphicity tests of arbitrary order. Secondly, we prove bounds on the probability of failure of a proposed affinity test that uses the BLR linearity test. All these bounds are expressed in terms of the function’s nonlinearity, and we exploit that to provide probabilistic methods for estimating the nonlinearity based upon these affinity tests. We analyze our estimates and conclude that they have reasonably good accuracy, particularly so when the nonlinearity is low.
Vulnerability pathways to mental health outcomes in children and parents during COVID-19
Authors: Rizeq Jala , Korczak Daphne J. , Cost Katherine Tombeau , Anagnostou Evdokia , Charach Alice , Monga Suneeta , Birken Catherine S. , Kelley Elizabeth , Nicolson Rob ,   Spit for Science, Burton Christie L. , Crosbie Jennifer 
Published: November 2021

AbstractWe examined pathways from pre-existing psychosocial and economic vulnerability to mental health difficulties and stress in families during the COVID-19 pandemic. Data from two time points from a multi-cohort study initiated during the COVID-19 pandemic were used. Parents of children 6–18 years completed questionnaires on pre-COVID-19 socioeconomic and demographic factors in addition to material deprivation and stress due to COVID-19 restrictions, mental health, and family functioning. Youth 10 years and older also completed their own measures of mental health and stress. Using structural equation modelling, pathways from pre-existing vulnerability to material deprivation and stress due to COVID-19 restrictions, mental health, and family functioning, including reciprocal pathways, were estimated. Pre-existing psychosocial and economic vulnerability predicted higher material deprivation due to COVID-19 restrictions which in turn was associated with parent and child stress due to restrictions and mental health difficulties. The reciprocal effects between increased child and parent stress and greater mental health difficulties at Time 1 and 2 were significant. Reciprocal effects between parent and child mental health were also significant. Finally, family functioning at Time 2 was negatively impacted by child and parent mental health and stress due to COVID-19 restrictions at Time 1. Psychosocial and economic vulnerability is a risk factor for material deprivation during COVID-19, increasing the risk of mental health difficulties and stress, and their reciprocal effects over time within families. Implications for prevention policy and parent and child mental health services are discussed.
Predicting employee telecommuting preferences and job outcomes amid COVID-19 pandemic: a latent profile analysis
Authors: Bakaç Cafer , Zyberaj Jetmir , Barela James C. 
Published: November 2021

AbstractIn this two-study research using latent profile analysis (LPA), we investigated intra-individual combinations of conscientiousness, autonomy, self-regulation, and extraversion. Based on these combinations, we designed profiles and explored telecommuting preferences and job outcomes of employees during the COVID-19 pandemic. In Study 1, we recruited 199 participants (77 females, ages ranging from 18 to 65). Results of this study revealed three profiles. One profile scored high on all of the variables and displayed preferences for working on-site more than the other profiles. Additionally, this profile showed higher work engagement, job satisfaction, and perceived productivity than the other two profiles. To validate these findings, we conducted a second study with a sample of 492 participants (169 females; age ranged from 18 to 65). The results yielded five profiles, one scoring high on all of the variables. Similar to Study 1, this profile exhibited higher work engagement, job satisfaction, and perceived productivity than the other four profiles. Individuals in this profile preferred to work on-site compared to individuals in other profiles. Our findings add to the research demonstrating the importance of personality characteristics for telecommuting preferences and work-related outcomes.
Evaluation of the Quick Wee method of inducing faster clean catch urine collection in pre-continent infants: a randomized controlled trial
Authors: Branagan Aoife , Canty Niofa , O’Halloran Evanne , Madden Marian , O’Neill Michael Brendan 
Published: November 2021

Abstract
Introduction
The acquisition of non-contaminated urine samples in pre-continent infants remains a challenge. The Quick Wee method uses bladder stimulation to induce voiding. A previous randomized trial showed a higher rate of voiding within 5 minutes using this method. We evaluated this method in an Irish hospital providing secondary care.

Methods
A non-blinded, randomized, controlled trial was carried out. Eligible infants were between 1 and 12 months of age, who required urine sampling as part of clinical care. Participants were randomly allocated to receive the intervention (Quick Wee Method—supra-pubic stimulation with cold saline) or the control (usual care—clean catch with no bladder stimulation) for 5 min. Primary outcome was voiding of urine within 5 min.

Results
A total of 140 infants were included in this study (73 in intervention group; 67 in control group). Baseline characteristics were similar. 25% in the intervention group passed urine in the 5-min trial period compared with 18% in the control group [P = 0.4, absolute difference 7% (95% confidence interval: − 7% to + 20%)].

Conclusion
The Quick Wee method is a simple and inexpensive intervention that did not show a statistically significant increase in urine samples obtained in pre-continent infants.
Rediscovering the largest kiln site in the middle Yangtze River Valley: insights into Qingbai and grey-greenish ware production at Husi kiln site based on bulk chemical analysis
Authors: Li Zihan , Doherty Chris , Hein Anke 
Published: November 2021

AbstractThis paper presents new data from the Husi kiln site, Hubei Province, China, where the unusual size calls into question the primacy of Jingdezhen in porcelain production in medieval China. With its over 180 kilns, the site rivals Jingdezhen in size, yet it has found no mention in textual accounts. The wares produced at Husi include Qingbai and grey-greenish ware of the Tang and the Song periods (seventh to thirteenth century AD). This paper presents compositional data obtained using LA-ICP-MS on samples from five kilns at Husi, comparing them with published data from other kilns. The data set Husi apart, thus allowing for fingerprinting its wares. Based on bulk chemical analysis, the paper furthermore explores the idea that Husi combined elements of southern and northern technologies, thus connecting these two ceramic traditions that previously had been seen as being entirely separate. Some key elements of the early Qingbai ware glaze from Husi resemble wares from Jingdezhen, suggesting a connection between the two sites; however, the glaze recipes for later wares found at Husi differ, indicating that its customer base and marketing strategy changed over time. Furthermore, the iron content of the grey-greenish ware from Husi is extraordinarily high, indicating a unique glaze recipe and production technology independent from Jingdezhen.
Regulatory Restrictions Across U.S. Protein Supply Chains
Authors: Staples Aaron J. , Chambers Dustin , Melstrom Richard T. , Malone Trey 
Published: November 2021

AbstractFood regulations protect consumer health, mitigate environmental concerns, and promote animal welfare, but they can also hinder innovation, limit entrepreneurship, and generate higher consumer prices. This study examines the number of federal and state regulatory restrictions affecting the beef, pork, poultry, sheep, goat, and seafood industries, including processing, wholesale distribution, and retail sales. We also examine state regulatory heterogeneity associated with animal protein products. Our results suggest that protein supply chains have become subject to tens of thousands of regulatory constraints over the past half-century. We also find substantial heterogeneity in the number of state restrictions associated with animal production, indicative of large differences in the amount of administrative law across states. Results highlight that the patchwork approach of U.S. food policy creates overlapping, cumbersome guidelines for manufacturers, and given the interconnectivity of modern food supply chains, the framework can create additional hurdles for interstate commerce.
Long-Term Prevalence of Disaster-Related Deep Vein Thrombosis in Minamiaso Village After the 2016 Kumamoto Earthquakes: A Prospective Cross-Sectional Analysis
Authors: Onishi Hidenori , Yamamura Osamu , Tsubouchi Hiromasa , Hirobe Takeshi , Kosugi Ikuko , Enomoto Soichi , Yamamoto Tami , Daitoku Satoshi , Satou Naomi , Chiba Hiroshi , Kai Yutaka , Hashimoto Yoichiro , Hamano Tadanori , Terasawa Hidekazu 
Published: November 2021

AbstractObjective:This study aimed to examine the prevalence of deep vein thrombosis (DVT) among evacuees in Minamiaso, a village which was temporarily isolated after the earthquakes, from the acute to recovery phase after the 2016 Kumamoto Earthquakes (GLIDE no: EQ-2016-000033-JPN).Methods:This prospective study, which was approved by Fukui University Medical Research Ethics Committee (approval no. 20160024 and 20160089), enrolled 181 evacuees (73.9 ± 11.6 y) who participated in a series of 3 DVT screenings using portable ultrasound machines conducted over 19 mo. All participants completed a questionnaire before the screenings, and none of the participants attended all 3 screenings. Data analysis was performed using EZR version 1.41.Results:The DVT prevalence was 14.3% (79.4 ± 8.2 y) at first screening of evacuees staying in shelters and 18.5% (71.5 ± 13.1 y) and 12.2% (72.8 ± 10.9 y) in second and third screenings of evacuees staying in temporary housing, respectively. Multivariate analysis revealed age ≥75 y and alcohol consumption as independent risk factors in the entire cohort and in patients aged ≤74 y, respectively.Conclusions:A high DVT prevalence over a long time period of 19 mo was observed where survivors were temporarily isolated after the disaster.
A criterion for normality of analytic mappings
Authors: Marković Marijan 
Published: November 2021

AbstractIn this paper, we give a generalization and improvement of the Pavlović result on the characterization of continuously differentiable functions in the Bloch space on the unit ball in $\mathbb {R}^{m}$. Then, we derive a Holland–Walsh type theorem for analytic normal mappings on the unit disk.
Duration of stenting with Montgomery T-tubes in severe laryngotracheal stenosis: does it matter?
Authors: Muraleedharan M , Ramavat A S , Bakshi J , Mohindra S , Nayak G , Goel A 
Published: November 2021

AbstractObjectiveLaryngotracheal stenosis management remains largely discretionary in surgical practice. Duration of stenting remains variable following open reconstruction procedures in absence of clearly established differences. The current study evaluates successful decannulation after short-term periods compared with longer periods.MethodA comparative study over 18 months evaluated differences in successful decannulation between short- and long-term stent groups. Patients with grade II, III or IV laryngotracheal stenosis were placed on Montgomery T-tube for a short-term period (n = 15), and decannulation rates were compared with age-, sex- and diagnosis-matched patients (n = 15) from historical cases with long-term stent placement.ResultsThirty patients were included. There was no difference between the two groups at baseline. Nine patients (30 per cent) were successfully decannulated, and there was no difference in rates of decannulation between the two groups (p = 0.8). Granulations at the proximal end of tube (38.7 per cent), superior migration of tube (16.1 per cent) and dysphonia (12.9 per cent) were common complications.ConclusionDecannulation was not more successful after placing Montgomery T-tubes for longer periods of time when compared with removal within the first three months. Early removal after proper case selection and planning may be considered for a successful outcome in laryngotracheal stenosis.
Representation and misrepresentation of knowledge
Authors: Gerken Mikkel 
Published: November 2021

Abstract
I argue for three points: First, evidence of the primacy of knowledge representation is not evidence of primacy of knowledge. Second, knowledge-oriented mindreading research should also focus on misrepresentations and biased representations of knowledge. Third, knowledge-oriented mindreading research must confront the problem of the gold standard that arises when disagreement about knowledge complicates the interpretation of empirical findings.
Knowledgeisbelief – and shaped by culture
Authors: Bender Andrea , Gatewood John B. 
Published: November 2021

AbstractPhillips and colleagues claim that the representation of knowledge is more basic than the representation of belief, presupposing them to be categorically distinct mental states with distinct evolutionary purposes. We argue that the relationship between the two is much more complex, is further shaped by culture and language, and leaves its mark on manifestations of theory of mind and teaching.
Representing knowledge, belief, and everything in between: Representational complexity in humans and other apes
Authors: Durdevic Kresimir , Krupenye Christopher 
Published: November 2021

Abstract
Building on Phillips and colleagues' case for the primacy of knowledge, we advocate for attention to diversity in mentalizing constructs within, as well as between, knowledge and belief. Ultimately, as great apes and other animals show, the development and evolution of theory of mind may reflect a much greater range of incremental elaborations of representational or computational complexity.
Are Adverse Childhood Experiences Associated with Worse Cognitive Function in Older Adults?
Authors: Halpin Amy B. , MacAulay Rebecca K. , Boeve Angelica R. , D’Errico Lisa M. , Michaud Sahvannah 
Published: November 2021

AbstractObjectives:Adverse childhood experiences (ACE) are associated with an increased risk for dementia, but this relationship and modifying factors are poorly understood. This study is the first to our knowledge to comprehensively examine the effect of ACE on specific cognitive functions and measures associated with greater risk and resiliency to cognitive decline in independent community-dwelling older adults.Methods:Verbal/nonverbal intelligence, verbal memory, visual memory, and executive attention were assessed. Self-report measures examined depression, self-efficacy, and subjective cognitive concerns (SCC). The ACE questionnaire measured childhood experiences of abuse, neglect, and household dysfunction.Results:Over 56% of older adults reported an adverse childhood event. ACE scores were negatively associated with income and years of education and positively associated with depressive symptoms and SCC. ACE scores were a significant predictor of intellectual function and executive attention; however, these relationships were no longer significant after adjusting for education. Follow-up analyses using the PROCESS macro revealed that relationships among higher ACE scores with intellectual function and executive attention were mediated by education.Conclusions:Greater childhood adversity may increase vulnerability for cognitive impairment by impacting early education, socioeconomic status, and mental health. These findings have clinical implications for enhancing levels of cognitive reserve and addressing modifiable risk factors to prevent or attenuate cognitive decline in older adults.
Patient and public involvement in a UK National Institute for Health Research Programme Grant for Applied Research: experiences from the Chronic Headache Education and Self-management Study (CHESS)
Authors: Nichols Vivien , Pearce Gemma , Ellard David R , Evans Simon , Haywood Kirstie , Norman Chloe , Potter Rachel , Sandhu Harbinder , Stewart Kimberley , Underwood Martin , Patel Shilpa 
Published: November 2021

AbstractBackground:Patient and public involvement (PPI) plays a crucial role in ensuring research is carried out in conjunction with the people that it will impact upon. In this article, we present our experiences and reflections from working collaboratively with patients and public through the lifetime of an National Institute for Health Research (NIHR) programme grant; the Chronic Headache Education and Self-management Study (CHESS) which took place between 2015 and 2020.PPI over the course of CHESS:We worked closely with three leading UK migraine charities and a lay advisory group throughout the programme. We followed NIHR standards and used the Guidance for Reporting Involvement of Patients and the Public checklist. We consulted our PPI contacts using a variety of methods depending on the phase of the study and the nature of the request. This included emails, discussions, and face-to-face contact.PPI members contributed throughout the study in the programme development, in the grant application, ethics documentation, and trial oversight. During the feasibility study; in supporting the development of a classification interview for chronic headache by participating in a headache classification conference, assessing the relevance, and acceptability of patient-reported outcome measures by helping to analyse cognitive interview data, and testing the smartphone application making suggestions on how best to present the summary of data collected for participants. Due to PPI contribution, the content and duration of the study intervention were adapted and a Delphi study with consensus meeting developed a core outcome set for migraine studies.Conclusions:The involvement of the public and patients in CHESS has allowed us to shape its overall design, intervention development, and establish a core outcome set for future migraine studies. We have reflected on many learning points for the future application of PPI.