bluuebunny/crossref_metadata_2025_split huggingface dataset:
ÇOCUĞUN KİŞİSEL VERİLERİNİN VELİSİ TARAFINDAN SOSYAL MEDYADA KULLANILMASININ KİŞİLİK HAKKI BAKIMINDAN DEĞERLENDİRİLMESİ
Authors: ERTUĞRUL Meltem 
Published: July 2021

Hayatın bir parçası haline gelen internetin yaygınlaşmasıyla, insanların sosyal medya platformlarını kullanması da giderek artmaktadır. Sosyal medya platformların çoğunluğu kişilerin isim, ses, görüntü gibi kişisel veri içeren bilgilerin paylaşılması esasına dayanmaktadır. İnsanların kendi kişisel verileri dışında, çocuklarının da verilerini sosyal medyada paylaşması sıklıkla görülen bir durumdur. Ancak masumca görülse dahi, geniş bir kitleye sunulan bu bilgiler, resimlerin değiştirilerek pedofili kişilerce kullanılması, çocuğun bilgilerinin öğrenilmesi sayesinde güvenliğinin tehlikeye düşmesi gibi sakıncalarının yanı sıra, çocukların kişilik hakkına saldırı da oluşturabilirler.
Kişilik hakkına yönelik davranışlar rıza, üstün özel veya kamu yararı gibi bazı durumlarda hukuka aykırı sayılmaz. Hukuka uygunluk sebeplerinden rıza, kural olarak velayet hakkına sahip olan veliler tarafından verilebilir. Ancak çocukların kişilik hakkına yönelik müdahalelerde rızanın kimin tarafından verileceği, velilerin velayet hakkına dayanarak kendi davranışlarına rıza gösterip gösteremeyecekleri hususu ayrıca değerlendirilmelidir.
Bu çalışmada velayet altındaki çocukların kişisel verilerinin, velisi olan ebeveynleri tarafından sosyal medyada kullanılmasının, çocuğun kişilik hakkına etkisi ve hakkın Türk Medeni Kanunu, Türk Borçlar Kanunu ile 6698 Sayılı Kanun hükümleri kapsamında korunması incelenmiştir.
Legal aspects of usage out-of-commerce works by libraries and other institutions
Authors: Trotska Valentyna 
Published: July 2021

Keywords: copyright; out-of-commerce works; cultural heritage institutions; exceptionsand limitation; representative organizations of collective management
The article is devoted to the study of the norms of Directive2019/790 of the European Parliament and of the Council on copyright and relatedrights in the Digital Single Market, such as provisions on the permitted use of worksout-of-commercial circulation, that are permanently in the collections of libraries andothers cultural heritage institutions. The norms of this EU Directive, as well as theprovisions defined in the laws of some European countries, are analyzed in detail.The main provisions of the EU Directive are considered, which provide for a doublemechanism of permitted use of works of cultural heritage institutions: main and reserve.The essence of each mechanism is considered in detail.The article also considers the question of when the rights holders have the right torefuse, meaning not to allow cultural heritage institutions to use out-of-commerce works.A comparison is made between the norms of the legislation of Ukraine on copyrightand related rights concerning the free use of works by libraries and other culturalheritage institutions and the relevant norms of European legislation. It is establishedthat in the legislation of Ukraine the list of institutions that have the right tofreely reproduce works is limited only to libraries and archives. Unlike the provisionsof the EU Directive, norms of national legislation do not apply to museums, film andaudio funds. However, free reproduction is allowed only by reprographic method (photocopying)of copies, which restrains the possibility of freeing reproduction (digitization)of works using modern digital technologies.It is concluded that classical norms of the legislation on copyright and relatedrights with the development of relations in the digital environment are changing.Legislators are constantly searching for optimal ways to balance public and privateinterests. Whether the new rules will be successful depends on how states implementthe rules of the EU Directive in state law and how they will be applied in practice.
Methodology of technology transfer in the field of intellectual property: economic and legal nature of the origin and definition of certain terms
Authors: Butnik-Siverskyi Oleksandr , Dorozhko Hryhorii 
Published: July 2021

Keywords: the concept of «technology transfer», technology fields, local and basictechnologies, the object of transfer, contractual relations, intellectual property.
The article considers the methodology of technologytransfer from the point of economic and legal content in the field of intellectualproperty. It is noted that there is no single definition of technology transfer, as scientistsin various fields interpret it due to the peculiarities of their field of activity. Atthe general level, the field of technology is considered as the birth of technologies,their types and maturity, which are the objects of transfer, taking into account the peculiaritiesof state regulation in the field of transfer. It is in the field of technologythat an invention (utility model) is born, as a result of intellectual, creative human activity;that is, they associate this process with the material carriers of technologies, orthe intangible phenomenon becomes a material state. The transfer of technology is associatedwith the transition to technical means, technological processes, and computernetworks. It is considered from the point of law as a type of communication betweenbusiness entities on the basis of contractual relations. It is determined thatfrom the point of methodology of technologies and their components transfer, theissue of technologies origin and the nature of their creation require in-depth study,and that is important to indicate the author(s) (owner(s)) of the result of intellectual,creative activity in the field of intellectual property. The main goal of the technology can be achieved only if there is a quantitative assessment of the perfection of theprocess and product quality. Technology uses two types of models: ideal objects ofbasic sciences, on the basis of which the most general laws and regularities of naturalsciences are formulated, and ideal objects of technology itself, on the basis of whichmorphological descriptions of separate stages and functional descriptions of the structureof technological lines are made. New local technologies are the result of inventions,utility models in the field of technologies, which have a specific author(s) (inventor(s)) and which are the object of transfer. Amendments to the terms of Article 1of the Law of Ukraine «On State Regulation of Technology Transfer Activities».
Biomechanical Identification of High-Risk Patients Requiring Permanent Pacemaker After Transcatheter Aortic Valve Replacement
Authors: Zhang Guangming , Liu Rong , Pu Min , Zhou Xiaobo 
Published: July 2021

BackgroundCardiac conduction disturbance requiring new permanent pacemaker implantation (PPI) is an important complication of TAVR that has been associated with increased mortality. It is extremely challenging to optimize the valve size alone to prevent a complete atrioventricular block (AVB).MethodsIn this study, we randomly took 48 patients who underwent TAVR and had been followed for at least 2 years to assess the risk of AVB. CT images of 48 patients with TAVR were analyzed using three-dimensional (3D) anatomical models of the aortic valve apparatus. The stresses were formulated according to loading force and tissue properties. Support vector regression (SVR) was used to model the relationship between AVB risk and biomechanical stresses. To avoid AVB, overlapping regions on the prosthetic valve where AV bundle passes will be removed as cylindrical sector with the angle θ. Thus, the optimization of the valve shape will be predicted with the joint optimization of the θ and valve size R.ResultsThe average AVB risk prediction accuracy was 83.33% in the range from 0.8–0.85 with 95% CI for all cases; specifically, 85.71% for Group A (no AVB), and 80.0% for Group B (undergoing AVB after the TAVR).ConclusionsThis model can estimate the optimal valve size and shape to avoid the risk of AVB after TAVR. This optimization may eliminate the excessive stresses to keep the normal function of both AV bundle and valve leaflets, leading to a favorable clinical outcome. The combination of biomechanical properties and machine learning method substantially improved prediction of surgical results.
Edge Mostar Indices of Cacti Graph With Fixed Cycles
Authors: Yasmeen Farhana , Akhter Shehnaz , Ali Kashif , Rizvi Syed Tahir Raza 
Published: July 2021

Topological invariants are the significant invariants that are used to study the physicochemical and thermodynamic characteristics of chemical compounds. Recently, a new bond additive invariant named the Mostar invariant has been introduced. For any connected graph ℋ, the edge Mostar invariant is described as Moe(ℋ)=∑gx∈E(ℋ)|mℋ(g)−mℋ(x)|, where mℋ(g)(or mℋ(x)) is the number of edges of ℋ lying closer to vertex g (or x) than to vertex x (or g). A graph having at most one common vertex between any two cycles is called a cactus graph. In this study, we compute the greatest edge Mostar invariant for cacti graphs with a fixed number of cycles and n vertices. Moreover, we calculate the sharp upper bound of the edge Mostar invariant for cacti graphs in ℭ(n,s), where s is the number of cycles.
Prognostic Value of Coronary Artery Calcium Score in Hospitalized COVID-19 Patients
Authors: Luchian Maria-Luiza , Lochy Stijn , Motoc Andreea , Belsack Dries , Magne Julien , Roosens Bram , de Mey Johan , Tanaka Kaoru , Scheirlynck Esther , Boeckstaens Sven , Van den Bussche Karen , De Potter Tom , von Kemp Berlinde , Galloo Xavier , François Clara , Weytjens Caroline , Droogmans Steven , Cosyns Bernard 
Published: July 2021

Background: The association of known cardiovascular risk factors with poor prognosis of coronavirus disease 2019 (COVID-19) has been recently emphasized. Coronary artery calcium (CAC) score is considered a risk modifier in the primary prevention of cardiovascular disease. We hypothesized that the absence of CAC might have an additional predictive value for an improved cardiovascular outcome of hospitalized COVID-19 patients.Materials and methods: We prospectively included 310 consecutive hospitalized patients with COVID-19. Thirty patients with history of coronary artery disease were excluded. Chest computed tomography (CT) was performed in all patients. Demographics, medical history, clinical characteristics, laboratory findings, imaging data, in-hospital treatment, and outcomes were retrospectively analyzed. A composite endpoint of major adverse cardiovascular events (MACE) was defined.Results: Two hundred eighty patients (63.2 ± 16.7 years old, 57.5% male) were included in the analysis. 46.7% patients had a CAC score of 0. MACE rate was 21.8% (61 patients). The absence of CAC was inversely associated with MACE (OR 0.209, 95% CI 0.052–0.833, p = 0.027), with a negative predictive value of 84.5%.Conclusion: The absence of CAC had a high negative predictive value for MACE in patients hospitalized with COVID-19, even in the presence of cardiac risk factors. A semi-qualitative assessment of CAC is a simple, reproducible, and non-invasive measure that may be useful to identify COVID-19 patients at a low risk for developing cardiovascular complications.
Responsible Relations: A Systematic Scoping Review of the Therapeutic Alliance in Text-Based Digital Psychotherapy
Authors: van Lotringen Charlotte M. , Jeken Lars , Westerhof Gerben J. , ten Klooster Peter M. , Kelders Saskia M. , Noordzij Matthijs L. 
Published: July 2021

Introduction: Developing a good therapeutic alliance is considered essential for the responsible delivery of psychotherapy. Text-based digital psychotherapy has become increasingly common, yet much remains unclear about the alliance and its importance for delivering mental health care via a digital format. To employ text-based digital therapies responsibly, more insight is needed into the type and strength of the therapeutic alliance online.Methods: A systematic scoping review was performed searching four databases: Scopus, PsycINFO, Web of Science, and Wiley Online Library. A total of 23 studies were selected and data was extracted and tabulated to explore the characteristics of studies on text-based psychotherapy, measurements of the therapeutic alliance and associations of the alliance with treatment outcome.Results: The therapeutic alliance in text-based digital interventions was studied with a variety of client groups, though mostly for clients diagnosed with anxiety and/or depression issues. Treatment modalities were predominantly internet-based cognitive behavioral therapy (ICBT) and tailored platforms for distinct client groups (e.g., PTSD). Almost all treatments used asynchronous text-based communication, such as e-mails and integrated messaging functions, which were mainly used to give feedback on tasks. For measurements, a version of the Working Alliance Inventory (WAI) was used in most studies. Measurements with the WAI or WAI- short form indicated a good therapeutic alliance with a weighted mean score of 5.66 (on a scale of 1 to 7) and a weighted standard deviation of 0.84. Relations between the therapeutic alliance and treatment outcomes were mostly positive, with many studies reporting significant associations (n = 8 out of 10) or significant effects of the therapeutic alliance on treatment outcomes (n = 5 out of 6).Discussion: Our scoping review suggests that a good therapeutic alliance can be established in digital psychotherapy through text-based communication, and shows support for a positive relationship between the alliance and treatment outcomes. These findings illustrate that text-based online psychotherapy can be a responsible treatment option as far as the establishment of the therapeutic alliance is concerned. However, current measures of the therapeutic alliance might miss important aspects of the alliance in digital treatment, such as the presence of empathy or compassion.
Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Ulcerative Colitis
Authors: Chen Zi-An , Sun Yu-Feng , Wang Quan-Xu , Ma Hui-Hui , Ma Zhi-Zhao , Yang Chuan-Jie 
Published: July 2021

Background: Ulcerative colitis (UC) is a chronic, complicated, inflammatory disease with an increasing incidence and prevalence worldwide. However, the intrinsic molecular mechanisms underlying the pathogenesis of UC have not yet been fully elucidated.Methods: All UC datasets published in the GEO database were analyzed and summarized. Subsequently, the robust rank aggregation (RRA) method was used to identify differentially expressed genes (DEGs) between UC patients and controls. Gene functional annotation and PPI network analysis were performed to illustrate the potential functions of the DEGs. Some important functional modules from the protein-protein interaction (PPI) network were identified by molecular complex detection (MCODE), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG), and analyses were performed. The results of CytoHubba, a plug for integrated algorithm for biomolecular interaction networks combined with RRA analysis, were used to identify the hub genes. Finally, a mouse model of UC was established by dextran sulfate sodium salt (DSS) solution to verify the expression of hub genes.Results: A total of 6 datasets met the inclusion criteria (GSE38713, GSE59071, GSE73661, GSE75214, GSE87466, GSE92415). The RRA integrated analysis revealed 208 significant DEGs (132 upregulated genes and 76 downregulated genes). After constructing the PPI network by MCODE plug, modules with the top three scores were listed. The CytoHubba app and RRA identified six hub genes: LCN2, CXCL1, MMP3, IDO1, MMP1, and S100A8. We found through enrichment analysis that these functional modules and hub genes were mainly related to cytokine secretion, immune response, and cancer progression. With the mouse model, we found that the expression of all six hub genes in the UC group was higher than that in the control group (P &lt; 0.05).Conclusion: The hub genes analyzed by the RRA method are highly reliable. These findings improve the understanding of the molecular mechanisms in UC pathogenesis.
Extreme Delta Brush in Anti-NMDAR Encephalitis Correlates With Poor Functional Outcome and Death
Authors: Nathoo Nabeela , Anderson Dustin , Jirsch Jeffrey 
Published: July 2021

Objective: To characterize EEG findings in anti-NMDAR encephalitis patients looking for the proportion of EEGs that were abnormal, presence of extreme delta brush (EDB), and to relate EEG findings to clinical outcomes (Glasgow Outcome Scale (GOS) at 6 months, need for ICU admission, and death).Methods: This retrospective cohort single center study included patients with anti-NMDAR encephalitis who had ≥1 EEGs obtained from 2014 to 2021. EEGs were retrospectively analyzed by 2 reviewers. Clinical outcomes of interest were extracted through hospital and clinic chart review.Results: Twenty-one patients with anti-NMDAR encephalitis were included. Sixty-four EEGs were analyzed. Four EEGs (6.3%) were within normal limits. Focal or generalized slowing (without EDB) was seen on 44 EEGs (68.8%). EDB was seen on 16 EEGs (25.0%) in 9 of 21 patients (42.9%). The presence of EDB was significantly associated with need for ICU admission (p = 0.02), poorer outcome at 6 months as per the GOS (p = 0.002), and with death (p=0.02). EDB was present on ≥1 EEG of every patient who died.Conclusions: The presence of EDB on EEG in anti-NMDAR encephalitis patients is associated with increased need for ICU admission, worse functional outcomes at 6 months, and risk of death.
Long Noncoding RNA DICER1-AS1 Functions in Methylation Regulation on the Multi-Drugresistance of Osteosarcoma Cells via miR-34a-5p and GADD45A
Authors: Wang Feng , Kong Lingsuo , Pu Youguang , Chao Fengmei , Zang Chunbao , Qin Wei , Zhao Fangfang , Cai Shanbao 
Published: July 2021

Osteosarcoma (OS) is a common malignant bone tumor that commonly occurs in children and adolescents. Long noncoding RNAs (lncRNAs) are recognized as a novel class of regulators of gene expression associated with tumorigenesis. However, the effect and mechanism of lncRNAs in OS tumorigenesis and drug resistance have not been characterized. The purpose of the study is to screen potential biomarker and therapeutic target against OS. We compared the lncRNA expression profiles between OS cell lines with different drug resistance levels using RNA-seq analysis and found that lncRNA DICER1-AS1 was significantly differentially expressed in multi-drugresistant OS cells SJSA-1 versus multi-drugsensitive OS cells G-292. Bisulfite Sequencing PCR (BSP) assay was performed to analyze the differential methylation status of the promoter region of DICER1-AS1 in four OS cells. Subsequently, in vitro gain- and loss-of-function experiments demonstrated the roles of DICER1-AS1 and miR-34a-5p in the multi-drugresistance of OS cells. The main findings is that DICER1-AS1 directly binds to miR-34a-5p, and their expression has a negative correlation with each other. The hypermethylation of the promoter region of DICER1-AS1 silenced its expression in the drugresistant cells SJSA-1 and MNNG/HOS. Moreover, we found that growth arrest and DNA damage-inducible alpha (GADD45A) participates in the DICER1-AS1/miR-34a-5p-regulated drug resistance of OS cells, probably via the cell cycle/pRb-E2F pathway. Our results revealed DICER1-AS1/miR-34a-5p-regulated drug resistance of OS cells, a new lncRNA-regulated network in OS tumorigenesis, suggested that DICER1-AS1 can be considered as a potential biomarker and therapeutic target against OS cells.
Continuous Glucose Monitoring as a Valuable Tool in the Early Detection of Diabetes Related to Cystic Fibrosis
Authors: Gojsina Bojana , Minic Predrag , Todorovic Sladjana , Soldatovic Ivan , Sovtic Aleksandar 
Published: July 2021

Aims: We evaluated the impact of cystic fibrosis-related diabetes (CFRD) on lung disease and nutritional status.Study Design: The retrospective cohort study evaluated the subjects' medical records from 2004 to 2019. All participants older than 10 years diagnosed by a 30-minutely sampled OGTT formed OGTT-CFRD subgroup. The participants diagnosed with continuous glucose monitoring (CGM) (at least two peaks above 11.1 mmol/l and more than 10% of recorded time above 7.8 mmol/l) formed a CFRD-CGM subgroup. The participants without CFRD formed a non-CFRD group. The longitudinal follow-up was made 2 years before and 3 years after insulin therapy initiation.Results: Of 144 participants included, aged 10–55 years (44% males), 28 (19.4%) had CFRD. The HbA1c was significantly lower in the CGM-CFRD in comparison to the OGTT-CFRD subgroup (5.9 ± 0.62 and 7.3 ± 1.7% respectfully; p = 0.04). Subjects with CFRD were malnourished in comparison to non-CFRD, with significant improvements with insulin replacement therapy in regard to BMI Z-score (−1.4 ± 1.3 vs. −0.5 ± 1.2%, p = 0.04) and pulmonary exacerbation score (p = 0.02). In OGTT-CFRD subgroup there is an increase in FEV1 (62.7 ± 26.3 to 65.1 ± 21.7%, p = 0.7) and decrease in FVC (from 76.4 ± 24.2 to 71.2 ± 20%, p = 0.003) from diagnosis to second year of follow-up. In CGM-CFRD subgroup there was a decrease in FEV1 (from 58.2 ± 28.2 to 52.8 ± 25.9%, p = 0.2) and FVC-values (from 72.4 ± 26.5 to 67.4 ± 29.1%, p = 0.08).Chronic Pseudomonas aeruginosa infection was more prevalent in the CFRD group (p = 0.003).Conclusion: Continuous glucose monitoring is a useful tool for insight of glucose impairment and diagnosis of CFRD. Early recognition of CFRD and therapeutic intervention has favorable effects on clinical course of the disease.
Gestational Weight Gain and Its Effects on Maternal and Neonatal Outcome in Women With Twin Pregnancies: A Systematic Review and Meta-Analysis
Authors: Zhong Wei , Fan Xiaojiao , Hu Fang , Chen Meiqin , Zeng Fanshu 
Published: July 2021

Background: The incidence of twin pregnancies has risen recently. Such pregnancies are associated with an increased risk for poor maternal and infant outcomes. Gestational weight gain, particularly in singleton pregnancies, has been well-linked with maternal and infant outcomes. The aim of the current meta-analysis was to evaluate the effects of gestational weight gain on maternal and fetal outcomes in women with twin pregnancies.Methods: A systematic search was conducted using the PubMed, Scopus, and Google Scholar databases. Studies, either retrospective or prospective in design, evaluating the effects of gestational weight gain (defined using Institute of Medicine (IOM) guidelines) maternal and/or fetal/neonatal outcomes in women with twin pregnancies were included. Statistical analysis was performed using STATA software.Results: Eleven studies were included in the meta-analysis. Mothers with inadequate weight gain had increased risk for gestational diabetes mellitus (OR 1.19; 95% CI: 1.01, 1.40) and decreased risk for gestational hypertension (OR 0.58; 95% CI: 0.49, 0.68) and cesarean section (OR 0.94; 95% CI: 0.93, 0.96). Neonates born to mothers with inadequate weight gain were susceptible to increased risk for preterm delivery (OR 1.17; 95% CI: 1.03, 1.34), very preterm delivery (gestational age &lt;32 weeks) (OR 1.84; 95% CI: 1.36, 2.48), small for gestational age status (OR 1.41; 95% CI: 1.15, 1.72), low birth weight status (&lt;2,500 g) (OR 1.27; 95% CI: 1.17, 1.38), and neonatal intensive care unit (NICU) admission (OR 1.16; 95% CI: 1.08, 1.24). The pooled findings indicate an increased risk for gestational hypertension (OR 1.82; 95% CI: 1.60, 2.06) and cesarean section (OR 1.07; 95% CI: 1.05, 1.08) among mothers with excessive weight gain. Neonates born to mothers with excessive weight gain were susceptible to increased risk for preterm delivery and very preterm delivery, but were associated with a decreased risk for low birth weight status and small for gestational age status.Conclusions: Gestational weight gain in twin pregnancy, either lower or higher than IOM recommended guidelines, is associated with poor maternal and neonatal outcomes. Our findings call for incorporating counseling on optimal weight gain during pregnancy as part of routine antenatal visits.