bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Establishment of Criteria for Molecular Differential Diagnosis of MPLC and IPM
Authors: Wang Xiaohui , Gong Yuan , Yao Jianfei , Chen Yan , Li Yuemin , Zeng Zhen , Lu Yinying , Song Lele 
Published: January 2021

BackgroundsDifferential diagnosis of multiple primary lung cancer (MPLC) and intrapulmonary metastasis (IPM) is one difficulty in lung cancer diagnosis, and crucial for establishment of treatment strategies and prognosis prediction. This study aims to establish the criteria for molecular differential diagnosis of synchronous MPLC and IPM by the next-generation sequencing (NGS) method.MethodsTraining cohort included 30 synchronous MPLC (67 samples) patients and 5 synchronous IPM (13 samples) patients with adenocarcinoma. Criteria of MPLC/IPM differential diagnosis were established by results from a NGS-based 605-gene panel test. Subsequently, 16 patients (36 samples) were recruited as the validation cohort to verify the criteria.ResultsIPM lesions showed a high degree of mutation overlap with an average concordance rate of 60.2% (range: 15.8%–91.7%). IPM lesions had at least three common alterations, including both high-frequency driver gene alterations and low-frequency gene alterations. In contrast, the average concordance rate of MPLC was 11.0% (range: 0.0%–100.0%), among which 66.7% (20/30) of patients had no common alterations (concordance rate: 0%). In the remaining 10 patients, 9 had only one overlapping alteration while 1 had two overlapping alterations, in which 6 patients had EGFR L858R overlapping mutation. Alterations were classified into trunk, shared, and branch subtypes. Branch alterations accounted for 94.4% of mutations in MPLC, while accounted for only 45.0% in IMP. In contrast, the ratio of trunk (38.3%) and shared (16.7%) alterations in IPM was significantly higher. The criteria for differentiating MPLC from IPM using 605-gene panel was established: 1) MPLC can be interpreted if no overlapping alterations is found; 2) MPLC is recommended if one overlapping high-frequency drive gene alteration and/or one overlapping low-frequency gene alteration are/is found; 3) IPM can be interpreted if more than three common alterations are found. Subsequently, 16 patients were recruited as the validation cohort in the single-blind manner to verify the criteria, and 14 MPLC and 2 IPM were identified, which was 100% consistent with the results from independent imaging and pathological diagnosis.ConclusionsNGS detection can distinguish synchronous MPLC from IPM and is a useful tool to assist differential diagnosis.
An Easily Overlooked Contamination of Syringes in Newborn Screening by Tandem Mass Spectrometry
Authors: Wang Yanyun , Sun Yun , Jiang Tao 
Published: January 2021

Background: Tandem mass spectrometry becomes a common and important test in newborn screening, but potential contamination of the equipment has largely been ignored.Methods: The source of contamination through Biosan quality control samples was examined prospectively, and further confirmed by retrospective analysis of patient samples.Results: We found that the source of contamination came from a syringe in the Biosan quality control samples. Furthermore, we found that a large number of indicators in the patient sample were interfered by syringe contamination in our center, and also in two other newborn screening centers, but the affected indicators were different in different screening centers.Conclusion: Syringe contamination will affect the detection of patient samples by tandem mass spectrometry and should be monitored carefully and immediately.
Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects
Authors: Mu Jianfei , Yang Fuping , Tan Fang , Zhou Xianrong , Pan Yanni , Long Xingyao , Zhao Xin 
Published: January 2021

Ilex kudingcha C.J. Tseng tea and insect tea, as traditional Chinese teas, are favored for their original craftsmanship, unique flavor, and biological functionality. In this study, ultra high-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS) was used to analyze the bioactive components of the extracts of Ilex kudingcha and insect tea, and D-galactose-induced aging mice were used to compare the in vivo anti-aging effects of Ilex kudingcha and insect tea extracts. The results were remarkable, UHPLC-QqQ-MS analysis showed that ITP contains 29 ingredients, while IKDCP contains 26 ingredients. However, due to the large differences in the content of the main chemical components in IKDCP and ITP, the effects are equally different. At the same time, the in vivo research results suggesting that the anti-aging effects of IKDCP and ITP (500 mg/kg) include the regulation of viscera indices of major organs; improvement in liver, skin, and spleen tissue morphology; decreased production of inflammatory cytokines; up regulation of SOD, CAT, GSH, GSH-PX, and T-AOC and down regulation of NO and MDA levels in serum and liver tissue; reductions in the concentration of pro-inflammatory factors, and increases in the concentration of anti-inflammatory factor. RT-qPCR and western blot assay also showed that IKDCP and ITP affect anti-aging by regulating the gene and protein expression of GSH-PX, GSH1, SOD1, SOD2, and CAT. The overall results indicate that ITP is more effective in treating oxidative damage in aging mice induced by D-galactose. Thus, ITP appears to be an effective functional drink owing to its rich nutritional components and anti-aging activities.
The Impact of Cannabidiol on Human Brain Function: A Systematic Review
Authors: Batalla Albert , Bos Julian , Postma Amber , Bossong Matthijs G. 
Published: January 2021

Background: Accumulating evidence suggests that the non-intoxicating cannabinoid compound cannabidiol (CBD) may have antipsychotic and anxiolytic properties, and thus may be a promising new agent in the treatment of psychotic and anxiety disorders. However, the neurobiological substrates underlying the potential therapeutic effects of CBD are still unclear. The aim of this systematic review is to provide a detailed and up-to-date systematic literature overview of neuroimaging studies that investigated the acute impact of CBD on human brain function.Methods: Papers published until May 2020 were included from PubMed following a comprehensive search strategy and pre-determined set of criteria for article selection. We included studies that examined the effects of CBD on brain function of healthy volunteers and individuals diagnosed with a psychiatric disorder, comprising both the effects of CBD alone as well as in direct comparison to those induced by ∆9-tetrahydrocannabinol (THC), the main psychoactive component of Cannabis.Results: One-ninety four studies were identified, of which 17 met inclusion criteria. All studies investigated the acute effects of CBD on brain function during resting state or in the context of cognitive tasks. In healthy volunteers, acute CBD enhanced fronto-striatal resting state connectivity, both compared to placebo and THC. Furthermore, CBD modulated brain activity and had opposite effects when compared to THC following task-specific patterns during various cognitive paradigms, such as emotional processing (fronto-temporal), verbal memory (fronto-striatal), response inhibition (fronto-limbic-striatal), and auditory/visual processing (temporo-occipital). In individuals at clinical high risk for psychosis and patients with established psychosis, acute CBD showed intermediate brain activity compared to placebo and healthy controls during cognitive task performance. CBD modulated resting limbic activity in subjects with anxiety and metabolite levels in patients with autism spectrum disorders.Conclusion: Neuroimaging studies have shown that acute CBD induces significant alterations in brain activity and connectivity patterns during resting state and performance of cognitive tasks in both healthy volunteers and patients with a psychiatric disorder. This included modulation of functional networks relevant for psychiatric disorders, possibly reflecting CBD’s therapeutic effects. Future studies should consider replication of findings and enlarge the inclusion of psychiatric patients, combining longer-term CBD treatment with neuroimaging assessments.
Language-Related Skills in Bilingual Children With Specific Learning Disorders
Authors: Riva Anna , Musetti Alessandro , Bomba Monica , Milani Lorenzo , Montrasi Valentina , Nacinovich Renata 
Published: January 2021

Purpose: The purpose of this study is to better understand the characteristics of the language-related skills of bilingual children with specific learning disorders (SLD). The aim is achieved by analyzing language-related skills in a sample of bilingual (Italian plus another language) and Italian monolingual children, with and without SLD.Patients and methods: A total of 72 minors aged between 9 and 11 were recruited and divided into four groups: 18 Italian monolingual children with SLD, 18 bilingual children with SLD, 18 Italian monolingual children without SLD, and 18 bilingual children without SLD. Each child underwent tests to evaluate different aspects of language skills: lexical and grammar, metalanguage and executive functions.Results: With regard to lexical and grammatical skills, the conditions of SLD and bilingualism both impact naming in terms of total number of errors for words with low frequency of use, while the condition of SLD has an effect on semantic errors for words with low frequency of use. The condition of bilingualism impacts on the total errors for words with high frequency of use and on circumlocution-type errors for words with low frequency of use. There were significant effects of bilingualism and SLD on the metalinguistic test for understanding implicit meaning, and an impact of SLD on phonological awareness was also found.Conclusion: The results suggest that both SLD and bilingualism have an effect on some lexical skills, in particular for words with low frequency of use. Both conditions, bilingualism and SLD, seem to impact on metalinguistic abilities that depend on lexical knowledge. These findings reinforce the importance of improving understanding of the neuropsychological profile of bilingual children with SLD.
Experience of implementing and delivering group consultations in UK general practice: a qualitative study
Authors: Swaithes Laura , Paskins Zoe , Duffy Helen , Evans Nicola , Mallen Christian , Dziedzic Krysia , Finney Andrew 
Published: January 2021

BackgroundGroup consultations are a relatively new concept in UK primary care and are a suggested solution to current workload pressures in general practice. Little is known about the experience of implementing and delivering this approach from staff and organisational perspectives.AimTo explore the experience of implementing and delivering group consultations in general practice.Design and settingQualitative telephone interview study.MethodTopic guides explored the perspectives and experiences of general practice staff on the implementation and delivery of group consultations. Data analysis adopted principles of the Framework Method underpinned by Normalisation Process Theory.ResultsInterviews were conducted with 8 GPs, 8 practice nurses, 1 nurse associate, 1 practice pharmacist, 1 deputy practice manager, and 1 healthcare assistant. Four themes were identified: sense making of group consultations; the work associated with initiating group consultations; the experiences of operationalising group consultations; and sustaining change. Group consultations made sense to participants as a mechanism to reduce burden on primary care, enhance multidisciplinary working, and provide patient-centred care. Implementation required strong leadership from a ‘champion’, and a facilitator had a pivotal role in operationalising the approach. The associated workload was often underestimated. Barriers to embedding change included achieving whole practice buy-in, competing practice priorities, and system-level flexibility.ConclusionGeneral practice clinicians enjoyed group consultations, yet significant work is required to initiate and sustain the approach. An implementation plan considering leadership, roles and responsibilities, and wider organisational support is required at the outset. Further research or evaluation is needed to measure process outcomes.
TEORI RASIONALITAS DALAM PANDANGAN ILMU EKONOMI ISLAM
Authors: Firmansyah Herlan 
Published: January 2021

ABSTRAKPandangan tentang konsep rasionalitas memiliki konsekuensi terhadap perilaku manusia dalam melakukan tindakan ekonomi dan tujuan-tujuan hidupnya. Rasionalitas ekonomi yang dibangun oleh konsepsi homo economicus sebagaimana dikembangkan dalam ekonomi kapitalis dan sosialis berbeda dengan rasionalitas ekonomi yang dibangun oleh konsepsi homo islamicus sebagaimana dikembangkan dalam ekonomi Islam. Tujuan dari artikel ini yaitu untuk menganalisis teori rasionalitas dalam perspektif ekonomi Islam. Kesimpulan dari artikel ini yaitu banyak ekonom Muslim yang tidak puas dengan konsep homo economicus sebagai model dasar perilaku ekonomi manusia. Karena itulah, ekonom Muslim pun menggantinya dengan konsepsi homo islamicus sebagai model dasar perilaku ekonomi yang sesuai dengan fitrah hakiki manusia. Istilah homo islamicus mengacu kepada perilaku individu yang dibimbing oleh nilai-nilai Islam. Rasonalitas yang dibangun oleh konsepsi homo islamicus berpandangan bahwa segenap tindakan ekonomi tidak hanya menuruti hasrat-hasrat alamiah manusia tetapi harus didasarkan kepada kebenaran dan kebajikan. Jalan untuk mencapai rasionalitas ini tidak lain adalah mensubordinatkan motif, pikiran, orientasi, kehendak dan perilau ekonomi kepada aturan dan moralitas yang ditentukan oleh syariat Islam. ABSTRACTThe view of the concept of rationality has consequences for human behaviour in carrying out economic actions and life goals. The economic rationality built by the conception of homo economicus as developed in a capitalist and socialist economy is different from the economic rationality built by the conception of homo islamicus as developed in Islamic economics. The purpose of this article is to analyze the rationality theory from an Islamic economic perspective. The conclusion of this article is that many Muslim economists are dissatisfied with the concept of homo economicus as a basic model of human economic behaviour. For this reason, Muslim economists also replaced it with the conception of homo islamicus as a basic model of economic behaviour in accordance with human nature. The term homo islamicus refers to individual behaviour that is guided by Islamic values. The rationality built by the conception of homo Islamic holds that all economic activity does not only comply with natural human desires but must be based on truth and virtue. The way to achieve this rationality is none other than subordinating economic motives, thoughts, orientation, will and behaviour to the rules and morality determined by Islamic law.
KONSEP SPIRITUAL MARKETING DALAM PEMASARAN PROGRAM STUDI EKONOMI SYARIAH FAKULTAS EKONOMI DAN BISNIS ISLAM UNIVERSITAS SURYAKANCANA
Authors: Husaeni Uus Ahmad , Farhany Huzni , Nurkomalasari Nina , Faisal Farid 
Published: January 2021

ABSTRAKTujuan penelitian ini adalah untuk menganalisis konsep spiritual marketing dalam pemasaran prodi Ekonomi Syariah Fakultas Ekonomi dan Bisnis Islam Universitas Suryakancana yang pada akhirnya terjadi peningkatan jumlah mahasiswa dari tahun ke tahun. Metode penelitian ini menggunakan penelitian kepustakaan (library research). Adapun metode pengolahan data yang digunakan adalah dengan mengumpulkan data-data yang diperoleh dari penelitian lapangan, peraturan-peraturan dan buku-buku yang diolah serta dianalisis dengan menggunakan metode kualitatif. Kesimpulan dari penelitian ini yaitu implementasi spiritual marketing dalam upaya memasarkan prodi-prodi pada Fakultas Ekonomi dan Bisnis Islam Universitas Suryakancana sangat dianjurkan, mengingat dampak dari penerapannya sangat menguntungkan bagi peningkatan jumlah mahasiswa. Implementasi konsep spiritual marketing pada akhirnya akan menumbuhkan rasa loyalitas dan trust pada benak masyarakat akan kredibilitasnya terhadap FEBI. Adapun keuntungan dalam jangka panjang, FEBI akan memperoleh wallet share dari siklus spiritual marketing yang dapat digunakan sebagai modal pengembangan ekonomi syariah dimasa yang akan datang. ABSTRACTThe purpose of this study is to analyze the concept of spiritual marketing in the marketing of the Islamic Economics Department which in turn has increased the number of students from year to year. This research method uses library research. The data processing method used is to collect data obtained from field research, regulations and books which are processed and analyzed using qualitative methods. The conclusion of this research is that the implementation of spiritual marketing in an effort to market of Islamic Economic department at the Faculty of Islamic Economics and Business (FEBI), Suryakancana University is highly recommended, considering the impact of its application is very beneficial for increasing the number of students. The implementation of the spiritual marketing concept will ultimately foster a sense of loyalty and trust in the minds of the public regarding its credibility towards FEBI. As for the long-term benefits, FEBI will get a wallet share from the spiritual marketing cycle which can be used as capital for the development of the Islamic economy in the future.
Physical and chemical enhancement of cancer cell death induced by cold atmospheric plasma
Authors: Rehman Mati Ur , Jawaid Paras , Zhao Qing-Li , Kondo Takashi , Saitoh Jun-ichi , Noguchi Kyo 
Published: January 2021

Abstract
Cold atmospheric plasma (CAP) has gained increasing attention for its anticancer potential. CAP anticancer application is unique for its selective targeting of cancer cells than normal cells. These CAP effects are directly related to producing reactive oxygen species (ROS) and reactive nitrogen species in air and liquid environment. The ROS producing ability can vary greatly depending on the CAP source. CAP-induced an enormous amount of ROS in the liquid phase. However, incorporating extracellular ROS into the cells seems limited to the ROS in the liquid phase. It poses a crucial challenge to CAP clinical applications. This short review describes the potential strategies that allow the incorporation of CAP-induced ROS to enhance cancer cell death. Further, the possible combination of CAP with hyperthermia and redox modulating agent sulfasalazine (SSZ) is explained.
ANALISIS PEMAKAIAN BAHASA DALAM SURAT DINAS DI BADAN PUBLIK SULAWESI TENGGARA
Authors: A.D. Firman , Husba Zakiyah Mustafa 
Published: January 2021

Penelitian ini menguraikan penggunaan bahasa surat di badan publik yang ada di Sulawesi Tenggara. Penelitian ini bersifat kualitatif deskriptif. Untuk menganalisis data surat dinas, digunakan analisis kesalahan berbahasa. Dalam mengidentifikasi dan mengklasifikasi data, digunakan teknik baca markah. Kesalahan-kesalahan penggunaan bahasa diidentifikasi menurut jenis, diklasifikasikan menurut tipe-tipe kesalahan, dan yang terakhir adalah dikoreksi menurut kesalahan. Hasil penelitian memperlihatkan bahwa penggunaan bahasa dalam surat dinas di intansi pemerintah daerah di Sulawesi Tenggara masih banyak kekeliruan. Kekeliruan itu dapat dilihat dalam ketidakseragaman penulisan dalam instansi yang sama. Kesalahan penggunaan ejaan banyak ditemukan dalam ketidaktepatan penggunaan huruf kapital. Nama jabatan dan nama pejabat ditulis dengan huruf kapital. Kesalahan juga ditemukan dalam pemakaian huruf tebal yang seharusnya tidak digunakan pada bagian hal surat, penulisan nama pejabat, dan penulisan nama jabatan serta ditambah lagi dengan penggunaan garis bawah. Kesalahan penulisan kata dasar umumnya terjadi pada kata serapan. Penulisan antara imbuhan {di-}dan kata depan di masih belum dapat dibedakan pemakaiannya. Selain itu, bentuk dan fungsi tanda hubung (-) dan tanda pisah (–) belum dapat dibedakan.Kesalahan lain yang umum terjadi dalam pemakaian tanda baca adalah ketidaktepatan penggunaan tanda titik (.), titik dua (:), tanda koma (,), tanda garis bawah (_), tanda kurung ((…)), dan tanda titik koma (;).Katakunci: surat dinas, badan publik, analisis kesalahan, Sulawesi Tenggara
Visualization for Analysis of Social Networking, Models and Techniques: A Review
Authors:   Shugufta Abrahim, Bilal Ahmed Mir, Faheem Ahmad Reegu, Shazia Farooq
Published: January 2021

In this paper, we have reviewed several social networking sites, evolution and background and significance of social media.	Social networking is used as platform for various applications like: government, business, educational, political, dating and matrimonial, etc. Motivation is to examine adversarial networks and represents the activities observed by analyser. Additionally we’ve examined social network model and operations performed in it along with simulation and close degree algorithm, Adversarial Network analyser and analysis of vulnerabilities of an organization analysed. We examine the types of posting on social media websites and influence of posting data and privacy concerns of Facebook and twitter users. This study indicates the different concerns of users regarding posting information and its influences of user based privacy concerns. In addition we discussed several classification and clustering techniques used for data mining in online social networking sites and the market targets and parameters and analysis of different variables as per the usage of SNSs.
Kajian Keberlanjutan Agribisnis Hortikultura di Kabupaten Sumba Barat
Authors: Leha Ernesta 
Published: January 2021

West Sumba is one of the regencies in Sumba island province of East Nusa Tenggara. Horticulture is a popular agricultural product there. The market potential for horticultural commodities in West Sumba is quite large but its production is still low. For this reason, the research was conducted with the aim of (1) knowing the sustainability status of horticultural agribusiness in West Sumba and (2) knowing the dominant attributes affecting the sustainability status of horticultural agribusiness development in the region. This is interesting to be examined since the sustainability is related to the ability of an area to increase production in the agricultural sector including the horticulture sub-sector. This study used the Multi-Dimensional Scaling (MDS) analysis method, which is modification of the Rapid Appraisal of the Status of Farming (RAP-farm) method. MDS analysis results show that (1) West Sumba Regency is in a fairly sustainable status for social and institutional dimensions while for the dimensions of ecology, economics and technology are in a less sustainable status and (2) the dominant attributes affecting each dimension are (a ) the ecological dimension is affected by the level of land slope and the level of erosion that occurs; (b) the economic dimension is affected by the management of horticultural products, the contribution to income per capita; (c) the social dimension is influenced by the existence of horticultural households and of government services; (d) technological dimensions by soil and water conservation technology and the application of technology; (e) the institutional dimension is influenced by conflicts between farmer groups, the availability of marketing institutions and the number of agricultural extension instructor.