bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental review on Majorana zero-modes in hybrid nanowires
Authors: Fu Ji-Bang , Li Bin , Zhang Xin-Fang , Yu Guang-Zheng , Huang Guang-Yao , Deng Ming-Tang 
Published: September 2021

AbstractAs the condensed matter analog of Majorana fermion, the Majorana zero-mode is well known as a building block of fault-tolerant topological quantum computing. This review focuses on the recent progress of Majorana experiments, especially experiments about semiconductor-superconductor hybrid devices. We first sketch Majorana zero-mode formation from a bottom-up view, which is more suitable for beginners and experimentalists. Then, we survey the status of zero-energy state signatures reported recently, from zero-energy conductance peaks, the oscillations, the quantization, and the interactions with extra degrees of freedom. We also give prospects of future experiments for advancing one-dimensional semiconductor nanowire-superconductor hybrid materials and devices.
Psychiatric Drug Prescription and Temporal Associations with a First Diagnosis of Gambling Disorder—Results from a National Register Study
Authors: Widinghoff Carolina , Berge Jonas , Hakansson Anders 
Published: September 2021

AbstractPsychiatric comorbidity is common in gambling disorder (GD), but there are few studies on larger nationwide samples of treatment-seeking patients. Also, temporal associations between GD and other psychiatric disorders are often difficult to study. To address the prevalence and the temporal associations of prescriptions for psychiatric disorders — both in specialized care and primary care — in patients with a GD diagnosis (ICD-10 F63.0). Data was derived from national health registers in Sweden. All patients who were diagnosed with GD in specialized health care in 2005–2016 were included and run against the nationwide database on prescription of pharmaceuticals aimed for psychiatric disorders (n = 2018). Prevalence of psychiatric drug prescription was used as a proxy for psychiatric comorbidity and studied for two 2-year periods (period 1 and 2) prior to GD and one 2-year period (period 3) after the diagnosis. Controlling for gender, age, and time periods, for eight drug categories (anti- epileptics, anti-psychotics, benzodiazepine derivatives, anxiolytics, hypnotics, anti- depressants and drugs used in addictive disorders), significant increases in drug prescription were seen. For central stimulants, a significant increase was seen upon receiving the GD diagnosis (from period 2 to 3), and for benzodiazepines, an increase was seen prior to the GD diagnosis (from period 1 to 2), but not upon diagnosis (from period 2 to 3). Psychiatric comorbidity in GD is common. Drug prescription for psychiatric problems increased markedly in the years temporarily associated with a first diagnosis of GD. The findings may call for early screening for problem gambling in patients with treatment contacts for increasingly poor mental health.
Esophageal Cancer After Bariatric Surgery: Increasing Prevalence and Treatment Strategies
Authors: Plat Victor D. , Kasteleijn Anne , Greve Jan Willem M. , Luyer Misha D. P. , Gisbertz Suzanne S. , Demirkiran Ahmet , Daams Freek 
Published: September 2021

Abstract
Purpose
The number of bariatric procedures has increased exponentially over the last 20 years. On the background of ever-increasing incidence of esophageal malignancies, the altered anatomy after bariatric surgery poses challenges in treatment of these cancers. In this study, an epidemiological estimate is presented for the future magnitude of this problem and treatment options are described in a retrospective multicenter cohort.

Methods
The number of bariatric procedures, esophageal cancer incidence, and mortality rates of the general population were used for epidemiological estimates. A retrospective multicenter cohort was composed; patients were treated in three large oncological centers with a high upper gastrointestinal cancer caseload. Consecutive patients with preceding bariatric surgery who developed esophageal cancer between 2014 and 2019 were included.

Results
Approximately 3200 out of 6.4 million post bariatric surgery patients are estimated to have developed esophageal cancer between 1998 and 2018 worldwide. In a multicenter cohort, 15 patients with esophageal cancer or Barrett’s esophagus and preceding bariatric surgery were identified. The majority of patients had a history of Roux-en-Y gastric bypass (46.7%) and had an adenocarcinoma of the distal esophagus (60%). Seven patients received curative surgical treatment, five of whom are still alive at last follow-up (median follow-up 2 years, no loss to follow-up).

Conclusion
Based on worldwide data, esophageal cancer development following bariatric surgery has increased over the past decades. Treatment of patients with esophageal cancer after bariatric surgery is challenging and requires a highly individualized approach in which optimal treatment and anatomical limitations are carefully balanced.

Graphical abstract
Improving quality prediction in radial-axial ring rolling using a semi-supervised approach and generative adversarial networks for synthetic data generation
Authors: Fahle Simon , Glaser Thomas , Kneißler Andreas , Kuhlenkötter Bernd 
Published: September 2021

AbstractAs artificial intelligence and especially machine learning gained a lot of attention during the last few years, methods and models have been improving and are becoming easily applicable. This possibility was used to develop a quality prediction system using supervised machine learning methods in form of time series classification models to predict ovality in radial-axial ring rolling. Different preprocessing steps and model implementations have been used to improve quality prediction. A semi-supervised approach is used to improve the prediction and analyze, to what extend it can improve current research in machine learning for quality prediciton. Moreover, first research steps are taken towards a synthetic data generation within the radial-axial ring rolling domain using generative adversarial networks.
The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy
Authors: Liu Huan , Wei Jing , Sang Na , Zhong Xi , Zhou Xia , Yang Xinyu , Zhang Jing , Zuo Zeping , Zhou Yang , Yang Shengyong , Du Junrong , Zhao Yinglan 
Published: September 2021

AbstractLysine-specific demethylase 1 (LSD1, also known as KDM1A) is an attractive agent for treatment of cancer. However, the anti-tumor effect of LSD1 inhibitors against diffuse large B-cell lymphoma (DLBCL) and the underlying mechanism are still unclear. Here, we report thatKDM1Ais overexpressed in human DLBCL tissues and negatively related to overall survival rate of DLBCL patients. ZY0511, a novel and potent LSD1 inhibitor developed by our group, inhibited the proliferation of human DLBCL cells. ZY0511 interacted with LSD1, induced methylation level of histone 3 lysine 4 and histone 3 lysine 9 in DLBCL cells. Mechanistically, transcriptome sequencing results indicated that ZY0511 induced the genes enrichment significantly related to cell cycle, autophagy, and apoptosis signaling pathways. Further study confirmed that ZY0511 blocked cell cycle at G0/G1 phase and expression of CDK4 and cyclin D1. ZY0511 decreased mitochondrial membrane potential and induced apoptosis, which can be reverted by a pan-caspase inhibitor, Z-VAD-FMK. Moreover, ZY0511 treatment significantly increased autophagy-associated marker proteins and autophagosomes formation in DLBCL cells. In vivo xenograft experiments confirmed that intraperitoneal administration of ZY0511 significantly suppressed SU-DHL-6 xenograft tumor growth in vivo. In conclusion, our findings identify that ZY0511 inhibits DLBCL growth both in vitro and in vivo via the induction of apoptosis and autophagy, and LSD1 inhibitor might be a promising strategy for treating DLBCL.
Risk premia and the European government bond market: new empirical evidence and some thoughts from the perspective of the life insurance industry
Authors: Tholl Johannes , Basse Tobias , Meier Samira , Rodriguez Gonzalez Miguel 
Published: September 2021

AbstractWe study yield spreads between government bonds in the European Monetary Union. This segment of the global fixed income market is of particular importance for insurance companies in Europe. Our empirical research strategy is inspired by Gunay (2020) who has analyzed the relationship between credit and liquidity risk in the United States using Granger causality tests. More specifically, we employ the procedure developed by Toda and Yamamoto (1995) to test for Granger causality among yield spreads in five different member countries of the European Monetary Union (namely Austria, Belgium, France, Italy and Ireland) relative to Germany. We examine interest rate data from bonds with three different maturities (5, 10 and 30 years). Given the importance of long-term bonds as asset class for European life insurers and pension funds, the empirical results from the often ignored market for government bonds with a maturity of 30 years should be of interest. With regard to long-term sovereign debt, there is no evidence for Granger causality among the time series examined here. Consequently, the risk premia required by investors to hold government bonds of one specific member country of the EMU do not help to forecast the risk premia that have to be paid by other countries. Given the structure of their liabilities, this empirical finding should be of high relevance for portfolio and risk managers in the European life insurance industry and in pension funds. With regard to the yield spreads to be observed in the market for 10-year government bonds, there seems to be no clear picture. Focusing on fixed income securities with a maturity of 5 years, there is one very interesting empirical finding. The test results reported here seem to imply that there is unidirectional Granger causality running from the yield spreads in all other four countries to Austria. Given that Austria is a comparably small country which is assumed to be in a fiscally stable position, this result could be interpreted as evidence for credit risk premia as being helpful to forecast liquidity risk premia in the market for medium-term government bonds issued by member states of the European Monetary Union.
Elucidating the Role of Cerebellar Synaptic Dysfunction in C9orf72-ALS/FTD — a Systematic Review and Meta-Analysis
Authors: Kaliszewska Aleksandra , Allison Joseph , Col Tarik-Tarkan , Shaw Christopher , Arias Natalia 
Published: September 2021

AbstractA hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) with synaptic dysfunction identified as an early pathological hallmark. Although TDP-43 pathology and overt neurodegeneration are largely absent from the cerebellum, the pathological hallmarks of RNA foci and dipeptide repeat protein (DPR) inclusions are most abundant. Here, we present a systematic literature search in the databases of PubMed, Scopus, Embase, Web of Science and Science Direct up until March 5, 2021, which yielded 19,515 publications. Following the exclusion criteria, 72 articles were included having referred to C9orf72, synapses and the cerebellum. Meta-analyses were conducted on studies which reported experimental and control groups with means and standard deviations extracted from figures using the online tool PlotDigitizer. This revealed dendritic defects (P = 0.03), reduced C9orf72 in human patients (P = 0.005) and DPR-related neuronal loss (P = 0.0006) but no neuromuscular junction abnormalities (P = 0.29) or cerebellar neuronal loss (P = 0.23). Our results suggest that dendritic arborisation defects, synaptic gene dysregulation and altered synaptic neurotransmission may drive cerebellar synaptic dysfunction in C9-ALS/FTD. In this review, we discuss how the chronological appearance of the different pathological hallmarks alters synaptic integrity which may have profound implications for disease progression. We conclude that a reduction in C9orf72 protein levels combined with the accumulation of RNA foci and DPRs act synergistically to drive C9 synaptopathy in the cerebellum of C9-ALS/FTD patients.
Methodology Proposed for Estimating Biowaste Generation Using Municipal Rurality Indexes
Authors: Baquero M. , Cifrian E. , Pérez-Gandarillas L. , Andrés A. 
Published: September 2021

AbstractThe separated collection and management of biowaste (BW) must be implemented in next years in the European countries. In order to define a proper BW strategy, it is necessary to estimate the generation at a municipal level, since depending on the amount to be treated, the strategy may notably vary. The aim of this study is to develop a methodology to estimate BW generation at municipal level taking into account the characteristics of the region, the Municipal Solid Waste management applied, and different socio-economic variables that define the level of rurality of a municipality. A model to estimate the BW generation for each type of municipality has been developed using Multiple Linear Regression Analysis. As input data, results from a Waste Compositional Analysis executed by the regional government to samples collected on 38 municipalities and data related to influential socio-economic variables have been used. Significant influence of socio-economic variables on BW generation is observed for the rural municipalities. The evolution of these characteristics, as well as the greater awareness of society with food waste, have change the consumption patterns. Therefore, it is not recommended to use static ratios, but models that allow including socio-economic changes in the estimation of waste generation.
Graphic Abstract
Indole Hydrazide Derivatives as Potential Corrosion Inhibitors for Mild Steel in HCl Acid Medium: Experimental Study and Theoretical Calculations
Authors: Sunil Dhanya , Kumari Preethi , Shetty Prakash , Rao Suma A 
Published: September 2021

AbstractThe present work highlights the corrosion inhibition action of two indole-3-hydrazides with varying alkyl chain lengths: 2-(1H-indol-3-yl)acetohydrazide (IAH) and 4-(1H-indol-3-yl)butanehydrazide (IBH) against mild steel (MS) in 0.5 M hydrochloric acid (HCl) solution using electrochemical and gravimetric measurement methods. Both IAH and IBH behaved as mixed-type inhibitors, and their anticorrosion behaviour was due to a protective film formation on MS surface through physisorption, in agreement with Langmuir’s adsorption model. The surface morphologies of the inhibited specimens examined using SEM and AFM images showed distinctive improvement against acid corrosion. The quantum mechanical calculations indicated the contribution of delocalized π-electrons in the indole unit and the lone-pair electrons in the carbonyl group for improved adsorption of the studied hydrazides onto the metal surface, supporting the experimental results. IAH and IBH showed maximum inhibition efficiency of 80.4 and 94.1% at 30 °C in MS exposed to 0.5 M HCl medium at its optimum concentration. The better resistance to MS corrosion was exhibited by the acid system-containing IBH bearing three methylene groups and hence having higher molar volume and surface coverage in comparison with IAH that incorporated only one methylene group in its chemical structure.
Efficient Concentration of PB From Water by Reactions With Layered Alkali Silicates, Magadiite and Octosilicate
Authors: Sruamsiri Donhatai , Sirinakorn Thipwipa , Ogawa Makoto 
Published: September 2021

AbstractHuman health problems are often related to contamination of the aqueous environment by toxic metal ions. In the present study, two layered alkali silicates (magadiite and octosilicate) were examined to assess removal of Pb2+ from aqueous solutions in terms of quantity and kinetics. The ion-exchange reaction between the silicates and aqueous solutions of lead(II) acetate at various concentrations was examined at room temperature for 24 h. The adsorption isotherms were H-type, showing the strong interactions between Pb2+ and the silicates. The amounts of Pb2+ adsorbed were as much as 1.23 mmol Pb/g magadiite and 2.32 mmol Pb/g octosilicate, which are larger than the reported values for various ion exchangers. They were larger than the theoretical cation exchange capacities (2.2 and 3.7 meq/g for magadiite and octosilicate, respectively), suggesting that the collection of Pb2+ included the precipitation as basic lead salts in addition to the ion exchange. The adsorption isotherms for magadiite and octosilicate fitted the Langmuir equation with correlation coefficients, R2, of 0.9991 and 0.9972, respectively. The adsorption of Pb2+ onto the layered alkali silicates from acidic aqueous solution was examined to obtain smaller amounts of adsorbed Pb2+ (0.32 mmol Pb/g magadiite and 0.34 mmol Pb/g octosilicate), confirming the important role of pH on the surface charge of the layered silicates in terms of ion exchange. The adsorption of Pb2+ reached equilibrium within 5 min for magadiite while it took 60 min for octosilicate. The difference was in the particle morphology; smoother diffusion of Pb2+ was possible through flower-shaped aggregates of particles of magadiite.
Can nudges save lives?
Authors: Ohtake Fumio 
Published: September 2021

AbstractTo assess the promotion of life saving behaviors and determine the sustainability of nudge message effects, this paper examines nudges that promote evacuation during heavy rainfall, preventative COVID-19 infection behaviors, and COVID-19 vaccination. The results showed that altruistic gain messages may have more sustained effects than others in promoting both evacuation during heavy rainfall and contact reduction behaviors as a measure against COVID-19 infection. Specifically, social influence nudges that use a gain frame to convey that a person’s behavior promotes the behavior of others are effective for both heavy rainfall evacuations and encouraging COVID-19 vaccination.
Heidegger's Concept of Experience: Derrida's Interpretation of Hegel in Heidegger: The Question of Being and History
Authors: Gissinger Simon 
Published: September 2021

AbstractIn 1971, answering a question concerning one of the main motifs of his works, Derrida declared that ‘if there were a definition of différance, it would be precisely the limit, the interruption, the destruction of the Hegelian “relève” [i.e. Aufhebung] wherever it operates’. It is apparent that such an approach to Hegel is indebted to Heidegger's program of a ‘destruction’ (Destruktion) of the history of ontology. But what does Derrida's reading of Hegel owe to Heidegger exactly? In this paper, I investigate this question and the genesis of Derrida's reading of Hegel more generally by looking into the interpretation which can be found in the 1964–65 lectures about Heidegger: The Question of Being and History. In the process of interpreting Heidegger, Derrida produces extensive comments about Hegel which document the early elaboration of his perception of the author of the Phenomenology of Spirit. Here, I focus on Hegel's conception of experience, which Derrida compares to Heidegger's understanding of the historicity of Dasein. As will become clear, however, this question involves the way Derrida presents the relationship between the two thinkers throughout these lectures. Specifically, I show that Derrida significantly bases his account of Heidegger's ‘destruction’ of Hegel's philosophy on the former's interpretation of the latter's concept of experience. By examining such an interpretation, I intend to challenge the way Derrida portrays Hegel and I argue as a result that it is questionable whether Heidegger's departure from Hegel can be taken to be as ‘radical’ as Derrida makes it seem.
The Evolutionary Map of the Universe pilot survey
Authors: Norris Ray P. , Marvil Joshua , Collier J. D. , Kapińska Anna D. , O’Brien Andrew N. , Rudnick L. , Andernach Heinz , Asorey Jacobo , Brown Michael J. I. , Brüggen Marcus , Crawford Evan , English Jayanne , Rahman Syed Faisal ur , Filipović Miroslav D. , Gordon Yjan , Gürkan Gülay , Hale Catherine , Hopkins Andrew M. , Huynh Minh T. , HyeongHan Kim , James Jee M. , Koribalski Bärbel S. , Lenc Emil , Luken Kieran , Parkinson David , Prandoni Isabella , Raja Wasim , Reiprich Thomas H. , Riseley Christopher J. , Shabala Stanislav S. , Sheil Jaimie R. , Vernstrom Tessa , Whiting Matthew T. , Allison James R. , Anderson C. S. , Ball Lewis , Bell Martin , Bunton John , Galvin T. J. , Gupta Neeraj , Hotan Aidan , Jacka Colin , Macgregor Peter J. , Mahony Elizabeth K. , Maio Umberto , Moss Vanessa , Pandey-Pommier M. , Voronkov Maxim A. 
Published: September 2021

AbstractWe present the data and initial results from the first pilot survey of the Evolutionary Map of the Universe (EMU), observed at 944 MHz with the Australian Square Kilometre Array Pathfinder (ASKAP) telescope. The survey covers$270 \,\mathrm{deg}^2$of an area covered by the Dark Energy Survey, reaching a depth of 25–30$\mu\mathrm{Jy\ beam}^{-1}$rms at a spatial resolution of$\sim$11–18 arcsec, resulting in a catalogue of$\sim$220 000 sources, of which$\sim$180 000 are single-component sources. Here we present the catalogue of single-component sources, together with (where available) optical and infrared cross-identifications, classifications, and redshifts. This survey explores a new region of parameter space compared to previous surveys. Specifically, the EMU Pilot Survey has a high density of sources, and also a high sensitivity to low surface brightness emission. These properties result in the detection of types of sources that were rarely seen in or absent from previous surveys. We present some of these new results here.
AN INTERCOMPARISON PROJECT ON 14C FROM SINGLE-YEAR TREE RINGS
Authors: Kudsk Sabrina G K , Olsen Jesper , Hodgins Gregory W L , Molnár Mihály , Lange Todd E , Nordby Jessica A , Jull A J Timothy , Varga Tamás , Karoff Christoffer , Knudsen Mads F 
Published: September 2021

ABSTRACTA laboratory intercomparison project was carried out on 20 annually resolved late-wood samples from the Danish oak record. The project included the following three laboratories: (1) the University of Arizona AMS Laboratory, University of Arizona, USA (AA); (2) HEKAL AMS Laboratory, MTA Atomki, Hungary (DeA); and (3) Aarhus AMS Centre (AARAMS), Aarhus University, Denmark (AAR). The large majority of individual data points (96%) lie within ±2σ of the weighted mean. Further assessment of the accuracy associated with the individual laboratories showed good agreement, indicating that consistent and reliable 14C measurements well in agreement with each other are produced at the three laboratories. However, the quoted analytical uncertainties appear to be underestimated when compared to the observed variance of differences from the geometric mean of the samples. This study provides a general quality check of the single-year tree-ring 14C measurements that are included in the new calibration curve.