bluuebunny/crossref_metadata_2025_split huggingface dataset:
Larval social cues influence testicular investment in an insect
Authors: Liu Junyan , He Xiong Z , Zheng Xia-Lin , Zhang Yujing , Wang Qiao 
Published: March 2021

AbstractSocio-sexual environment can have critical impacts on reproduction and survival of animals. Consequently, they need to prepare themselves by allocating more resources to competitive traits that give them advantages in the particular social setting they have been perceiving. Evidence shows that a male usually raises his investment in sperm after he detects the current or future increase of sperm competition because relative sperm numbers can determine his paternity share. This leads to the wide use of testis size as an index of the sperm competition level, yet testis size does not always reflect sperm production. To date, it is not clear whether male animals fine-tune their resource allocation to sperm production and other traits as a response to social cues during their growth and development. Using a polygamous insect Ephestia kuehniella, we tested whether and how larval social environment affected sperm production, testis size, and body weight. We exposed the male larvae to different juvenile socio-sexual cues and measured these traits. We demonstrate that regardless of sex ratio, group-reared males produced more eupyrenes (fertile and nucleate sperm) but smaller testes than singly reared ones, and that body weight and apyrene (infertile and anucleate sperm) numbers remained the same across treatments. We conclude that the presence of larval social, but not sexual cues is responsible for the increase of eupyrene production and decrease of testis size. We suggest that male larvae increase investment in fertile sperm cells and reduce investment in other testicular tissues in the presence of conspecific juvenile cues.
A rapid and accurate method for screening T-2 toxin in food and feed using competitive AlphaLISA
Authors: Zhang Liwen , Lv Qingyu , Zheng Yuling , Chen Xuan , Kong Decong , Huang Wenhua , Liu Peng , Jiang Hua , Jiang Yongqiang 
Published: March 2021

ABSTRACT
T-2 is a common mycotoxin contaminating cereal crops. Chronic consumption of food contaminated with T-2 toxin can lead to death, so simple and accurate detection methods in food and feed are necessary. In this paper, we establish a highly sensitive and accurate method for detecting T-2 toxin using AlphaLISA. The system consists of acceptor beads labeled with T-2-bovine serum albumin (BSA), streptavidin-labeled donor beads and biotinylated T-2 antibodies. T-2 in the sample matrix competes with T-2-BSA for antibodies. Adding biotinylated antibodies to the test well followed by T-2 and T-2-BSA acceptor beads yielded a detection range of 0.03–500 ng/mL. The half-maximal inhibitory concentration was 2.28 ng/mL and the coefficient of variation was &lt;10%. In addition, this method had no cross-reaction with other related mycotoxins. This optimized method for extracting T-2 from food and feed samples achieved a recovery rate of approximately 90% in T-2 concentrations as low as 1 ng/mL, better than the performance of a commercial ELISA kit. This competitive AlphaLISA method offers high sensitivity, good specificity, good repeatability and simple operation for detecting T-2 toxin in food and feed.
Bacteriophage manipulation of the microbiome associated with tumour microenvironments-can this improve cancer therapeutic response?
Authors: Kabwe Mwila , Dashper Stuart , Bachrach Gilad , Tucci Joseph 
Published: March 2021

ABSTRACTSome cancer treatment failures have been attributed to the tumour microbiota, with implications that microbiota manipulation may improve treatment efficacy. While antibiotics have been used to control bacterial growth, their dysbiotic effects on the microbiome, failure to penetrate biofilms and decreased efficacy due to increasing antimicrobial resistance by bacteria, suggest alternatives are needed. Bacteriophages may provide a precise means for targeting oncobacteria whose relative abundance is increased in tumour tissue microbiomes. Fusobacterium, Streptococcus, Peptostreptococcus, Prevotella, Parvimonas, and Treponema species are prevalent in tumour tissue microbiomes of some cancers. They may promote cancer growth by dampening immunity, stimulating release of proinflammatory cytokines, and directly interacting with cancer cells to stimulate proliferation. Lytic bacteriophages against some of these oncobacteria have been isolated and characterised. The search continues for others. The possibility exists for their testing as adjuncts to complement existing therapies. In this review, we highlight the role of oncobacteria, specifically those whose relative abundance in the intra-tumour microbiome is increased, and discuss the potential for bacteriophages against these micro-organisms to augment existing cancer therapies. The capacity for bacteriophages to modulate immunity and kill specific bacteria makes them suitable candidates to manipulate the tumour microbiome and negate the effects of these oncobacteria.
Consecutive cycles of accreditation and quality of in-hospital care: a Danish population-based study
Authors: Falstie-Jensen Anne Mette , Bogh Søren Bie , Johnsen Søren Paaske 
Published: March 2021

Abstract

Background
Little is known about whether repeated cycles of hospital accreditation are a robust method to improve quality of care continuously.

Objective
We aimed to examine the association between compliance with consecutive cycles of accreditation and quality of in-hospital care.

Methods
We conducted a Danish nationwide population-based study including patients aged 18 years treated for acute stroke, chronic obstructive pulmonary disease, diabetes, heart failure or hip fracture at public, non-psychiatric hospitals. From 2012 to 2015, two cycles of national hospital accreditation were completed, resulting in 12 high and 14 low compliant hospitals (Low = partially accredited in both cycles). Our outcome measure was quality of in-hospital care measured by 39 process performance measures (PPMs), reflecting recommendations from the national clinical guidelines by adherence to (i) individual PPMs and (ii) the full bundle of PPMs (all-or-none). We computed adjusted odds ratios (ORs) using logistic regression based on robust standard error estimation for cluster sampling of data at hospital level.

Results
In total, 78 387 patient pathways covering 508 816 processes were included, of which 47% had been delivered at high compliant hospitals and 53% at low compliant hospitals, respectively. Compliance with consecutive cycles was not associated with improved quality of in-hospital care (individual: OR = 0.92, 95% confidence interval (CI): 0.77–1.10; All-or-none: OR = 0.87, 95% CI: 0.66–1.15). However, in the second cycle alone, patients treated at partially accredited hospitals had a lower adherence than patients treated at fully accredited hospitals (Individual: OR = 0.84, 95% CI: 0.71–0.99; All-or-none: OR = 0.78, 95% CI: 0.59–1.03). The association was particularly strong among patients treated at partially accredited hospitals required to submit additional documentation.

Conclusion
Compliance with consecutive cycles of hospital accreditation in Denmark was not associated with improved quality of in-hospital care. However, compliance with the second cycle alone was associated with improved quality of in-hospital care.
Between Discipline and Neglect: The Regulation of Asylum Accommodation in Spain
Authors: Gabrielli Lorenzo , Garcés-MascareÑas Blanca , Ribera-Almandoz Olatz 
Published: March 2021

AbstractIn 2019, Spain had the third highest number of asylum applications in the Europen Union, after Germany and France. The number of asylum applications grew from 31,120 in 2017 to 55,668 in 2018 and 118,264 in 2019. Following this exponential increase, the number of accommodation places in the state reception system has risen almost proportionally. In this changing context, this article seeks to explain the regulation of asylum accommodation in Spain. Following critical refugee studies in the Global North and the Global South, we argue that the Spanish asylum reception system is characterized by a hybrid model that imposes forms of discipline and neglect. By using a mixed-methods approach combining document analysis of secondary data, in-depth interviews with both stakeholders and asylum seekers, and an exploratory survey to 301 asylum seekers, we analyse the implications of this hybrid model in terms of asylum seekers trajectories and eventual inclusion.
Recrudescence ofPlasmodium falciparummalaria in a migrant treated by tocilizumab
Authors: Cordaillat Romain , Carnino Luisa , Eperon Gilles 
Published: March 2021

We report an atypical case of recrudescence of Plasmodium falciparum in a migrant with 4% parasitemia, 7 years after leaving endemic country. This case supports the hypothesis of recrudescence of a latent and persistent sub-microscopic parasitemia, triggered by time-related decreasing immunity and immunosuppression (tocilizumab).
A Failure of Rapid Drug Desensitization
Authors: Prewitt Benjamin S , Mendoza Jun C , Coop Christopher A , Weiss Samuel , Quinn James M 
Published: March 2021

ABSTRACT
We present the case of a patient who was unable to tolerate rapid drug desensitization protocol to receive a continuous penicillin (PCN) G infusion for the treatment of neurosyphilis. A 38-year-old male with past medical history for human immunodeficiency virus, migraines, PCN allergy, doxycycline allergy, shellfish allergy, and untreated latent syphilis presented to the emergency room for a posterior migraine with associated nausea, vomiting, photophobia, right-sided paresthesias, and “shaky” vision. He was diagnosed with neurosyphilis and underwent rapid drug desensitization with the goal to receive a continuous infusion of PCN G. The patient’s hospital course was complicated by intermittent drug reactions consisting of tachycardia, rash, and dyspnea, followed by periods of being able to tolerate the infusion. After being able to tolerate the recommended dose of PCN infusion, the patient was discharged home to complete the course. However, he returned almost immediately after a recurrence of symptoms at home requiring the use of intramuscular epinephrine. Ultimately, the patient was transitioned to ceftriaxone and completed the infusion course as an inpatient because of continued intermittent recurrence of drug reaction symptoms.
The Nation as Imperative: Cooperative Nationalism and the Idea of the State in Martin Buber and Hermann Cohen
Authors: Biemann Asher D 
Published: March 2021

Abstract
Imperatives, as Immanuel Kant observed, differ from laws. Laws set limits through coercion, whereas imperatives imagine infinity through freedom. What does it mean for the nation to be an imperative? Starting with the famous 1916 controversy on Zionism between the neo-Kantian philosopher Hermann Cohen and the philosopher of dialogue Martin Buber, this essay explores how Buber developed Cohen’s dialectic of Machtstaat (power-state) and Kulturstaat (culture-state) into a model of cultural cooperation. Unlike Cohen, whose understanding of nation and nationality relied on Herder and Fichte, and who feared that Zionism would always be exclusionary, Buber believed that Zionism could be the inclusive self-realization of the Jewish people. Yet Buber’s Zionism of meta-national cooperation also deeply echoed Cohen’s own understanding of the German State as transcending itself in cooperative federalism. In the end, both believed that human culture offered ways of solidarity and community that the state per se could not provide and which, in fact, functioned as a corrective to the state’s “omnipotence.” For Buber, the pragmatic acceptance of the State of Israel was but the beginning of a meta-political imperative articulated by the prophets, and anticipated a time when the state, as Cohen believed, would be “displaced by messianism.”
Staggered Boards and the Value of Voting Rights
Authors: Karakas¸ Oğuzhan , Mohseni Mahdi 
Published: March 2021

Abstract
This paper examines the impact of staggered boards on the value of voting rights (i.e., the voting premium) estimated using option prices. We find companies with staggered boards have a higher voting premium. Exploiting plausibly exogenous court rulings, we confirm that weakening the effectiveness of staggered boards decreases the voting premium. Given that the voting premium reflects private benefits consumption and associated managerial inefficiencies, our findings are consistent with the entrenchment view of staggered boards. Analyzing the cross-sectional heterogeneity in our sample, we find the entrenchment effect of staggered boards to be particularly pronounced for firms in noncompetitive industries and for mature firms. (JEL G13, G30, G34, K22)
SIZE-SPECIFIC DOSE ESTIMATES FOR PEDIATRIC NON-CONTRAST HEAD CT SCANS: A RETROSPECTIVE PATIENT STUDY IN TUNJA, COLOMBIA
Authors: Jaramillo-Garzón W , Caballero M A , Alvarez-Aldana D F 
Published: March 2021

Abstract
This investigation is aimed to study the feasibility of size-specific dose estimate (SSDE) to patient dosimetry in pediatric head CT scans and to establish typical values in a hospital in Tunja, Colombia. The volumetric computed tomography index (CTDIvol) and the dose-length product of 468 pediatric patients from newborn to 15-year-olds, who underwent non-contrast head CT scans, were collected retrospectively. For 186 cases only, SSDE was estimated using patient attenuated-based size metrics and CTDIvol,16-to-SSDE conversion factors reported in AAPM report 293. Results showed that SSDE is an accurate metric that can be used to establish typical dose values from pediatric head CT scans. Median SSDE values of 33.5, 31.6, 36.2 and 57.9 mGy were established as typical dose values for the 0–&lt;3 months, 3 months–&lt;1 y, 1–&lt;6 y and ≥6 y, respectively, to further assist the optimization process at the hospital. Further studies with more robust data of patients and hospitals should be conducted to establish local and national dose reference levels from pediatric CT scans in Colombia.
Revision of Beroidae (Ctenophora) in the southern seas of Europe: systematics and distribution based on genetics and morphology
Authors: Shiganova Tamara A , Abyzova Galina A 
Published: March 2021

AbstractGenetic and morphological analyses were used to revise historical controversies in identities of Beroe species in the southern seas of Europe. DNA analyses with ITS sequences were used to explore their phylogenetic relationships. Three species of Beroe were initially listed as occurring in the Mediterranean Sea. Recently, the specimens were often re-identified using genetic analyses, causing confusions of identity. In 1997, a non-native Beroe was introduced into the Black Sea, which established there and spread to the adjacent seas, adding more controversy and confusion to species identification in this group of comb jellies.Our revisions suggest the following systematic changes: (1) re-naming of the species from what was initially labelled as Beroe ovata, and later as B. cucumis (sensuMayer, 1912), to Beroe pseudocucumis sp. nov.. (2) Beroe mitrata but not Beroe ‘anatoliensis’ inhabits the Aegean Sea, as was reported previously. (3) Beroe ovata is the only species of Beroidae that became invasive and should be used with the authority of Bruguière, 1789, but not in the sense of Mayer, 1912. (4) Beroe forskalii appears to be represented by two species in the Mediterranean and in the Antarctic, but further justification is needed. (5) Beroe cucumis is a species of bipolar occurrence, inhabiting both subpolar areas and its recent definition as Beroe ‘norvegica’ is incorrect.
A Rule of Thumb for Evaluating Surface Areas of Chronic Wounds
Authors: Yao Zexin , He Suiping , Pang Mengru , Lei Xiaoxuan , Wu Cuiwen , Lin Enqing , Cao Zhilong , Jiang Wencai , Fu Xiaobing , Cheng Biao 
Published: March 2021

ABSTRACT

BACKGROUND
Rapid estimation of the area of chronic wounds is clinically important. A simple method using the thumb was investigated for universal physical measurement, particularly of small and multiple wounds; the thumb surface area (TSA) was then compared with the total body surface area (TBSA).

METHODS
A cross-sectional observational study and random sampling were used to obtain the characteristics of 343 participants. Data related to handprint surface area of the thumb and palm were collected using a scanner and laptop and assessed using image software. The TSA as a percentage of TBSA was confirmed based on the traditional rule that regards palmar surface area as 1% of TBSA. Information on factors potentially influencing measurement was gathered with questionnaires to analyze correlations.

RESULTS
The left and right TSAs were on average 4.27% and 4.28%, respectively, of the palmar surface area for all participants. Multiple linear regression analysis found that male and older participants had higher TSA:TBSA proportions (sex, P = .0020; age, P < .0001). The TSA:TBSA proportion increased by age for both males (by age group, 0.0418%, 0.0426%, 0.0432%, and 0.0460%, respectively) and females (0.0400%, 0.0409%, 0.0427%, and 0.0430%, respectively).

CONCLUSIONS
Thumb size is relatively stable in relation to TBSA, lending itself to a universal method for estimating the size of chronic wounds as a percentage of TBSA. It therefore represents a convenient physical measurement for assessing the area of burns and other wounds.
Unique factors to the implementation of a disaster preparedness plan at Georgetown Public Hospital in Guyana
Authors: Van Meter Jessica , Lauderdale Jana , Rohde John Paul 
Published: March 2021

Abstract:
Disaster planning in developing countries is largely ineffective despite these countries being more likely to suffer from catastrophic events. This article aims to identify strengths, educational needs, practice improvement opportunities, and local factors that may contribute to the development/implementation of a disaster preparedness plan at Georgetown Public Hospital in Guyana.
Outpatient Cervical Ripening
Authors: McDonagh Marian , Skelly Andrea C. , Tilden Ellen , Brodt Erika D. , Dana Tracy , Hart Erica , Kantner Shelby N. , Fu Rongwei , Hermesch Amy C. 
Published: March 2021

OBJECTIVE:
To assess the comparative effectiveness and potential harms of cervical ripening in the outpatient compared with the inpatient setting, or different methods of ripening in the outpatient setting alone.

DATA SOURCES:
Searches for articles in English included MEDLINE, EMBASE, CINAHL, Cochrane Library, ClinicalTrials.gov, and reference lists (up to August 2020).

METHODS OF STUDY SELECTION:
Using predefined criteria and DistillerSR software, 10,853 citations were dual-reviewed for randomized controlled trials (RCTs) and cohort studies of outpatient cervical ripening using prostaglandins and mechanical methods in pregnant women at or beyond 37 weeks of gestation.

TABULATION, INTEGRATION, AND RESULTS:
Using prespecified criteria, study data abstraction and risk of bias assessment were conducted by two reviewers, random-effects meta-analyses were conducted and strength of evidence was assessed. We included 30 RCTs and 10 cohort studies (N=9,618) most generalizable to women aged 25–30 years with low-risk pregnancies. All findings were low or insufficient strength of evidence and not statistically significant. Incidence of cesarean delivery was not different for any comparison of inpatient and outpatient settings, or comparisons of different methods in the outpatient setting (most evidence available for single-balloon catheters and dinoprostone). Harms were inconsistently reported or inadequately defined. Differences were not found for neonatal infection (eg, sepsis) with outpatient compared with inpatient dinoprostone, birth trauma (eg, cephalohematoma) with outpatient compared with inpatient single-balloon catheter, shoulder dystocia with outpatient dinoprostone compared with placebo, maternal infection (eg, chorioamnionitis) with outpatient compared with inpatient single-balloon catheters or outpatient prostaglandins compared with placebo, and postpartum hemorrhage with outpatient catheter compared with inpatient dinoprostone. Evidence on misoprostol, hygroscopic dilators, and other outcomes (eg, perinatal mortality and time to vaginal birth) was insufficient.

CONCLUSION:
In women with low-risk pregnancies, outpatient cervical ripening with dinoprostone or single-balloon catheters did not increase cesarean deliveries. Although there were no clear differences in harms when comparing outpatient with inpatient cervical ripening, the certainty of evidence is low or insufficient to draw definitive conclusions.

SYSTEMATIC REVIEW REGISTRATION:
PROSPERO, CRD42020167406.
Rotational Composite Flap Technique for Primary Incomplete Cleft Nose Deformity
Authors: Rossell-Perry Percy 
Published: March 2021

Background:
Nasal deformities accompanying unilateral incomplete cleft lip have minor skeletal and soft tissue deficiencies compared with deformities associated with unilateral complete cleft lip. Extended dissection and surgical incisions (often required for nasal deformities in complete cleft lip) are not recommended to address deformities accompanying incomplete cleft lip. The purpose of this study is to describe an innovative method involving a rotational composite flap for nasal repair in patients with unilateral cleft lip.

Methods:
Since 2016, 49 consecutive patients with unilateral incomplete cleft lip have undergone primary anatomical repair of accompanying nasal deformities. The technique involves a skin incision along the marginal and intercartilaginous borders to create a V-shaped composite flap consisting of vestibular skin and alar cartilage. Rotational mobilization of the composite flap creates a triangular raw surface laterally, which is closed by advancement of the vestibular skin.

Results:
This innovative method, which is based on the use of a rotational composite vestibular flap, achieves proper symmetry of the repaired nose.

Conclusion:
The herein described composite flap rhinoplasty is a good surgical option, which provides a good overall nasal symmetry in patients with nasal deformities accompanying unilateral incomplete cleft lip.
The Laterally Extended Paramedian Forehead Flap for Nasal Reconstruction: The Delay Technique Revisited
Authors: Itani Yoshihito , Yotsuyanagi Takatoshi , Yamauchi Makoto , Sugai Asuka , Kato Shinji , Yamashita Ken , Isogai Noritaka 
Published: March 2021

Background:
Problems with poor circulation often occur when a large defect or a distant region, such as the apex of the nose, is covered with a paramedian forehead flap. Delay technique increases the safety of reconstruction procedures, but it has been used less frequently because a 2-stage surgery is necessary, and various other flaps and techniques have been developed.

Method:
We performed the delay technique of paramedian forehead flap at the same time as tumor resection. For the flap, a narrow pedicle of about 1-cm was prepared on the supratrochlear artery and vein, and the incision was extended toward the lateral side conforming to the defect morphology, and a paramedian forehead flap with a design consistent with the esthetic unit containing the defect was prepared. The region below the flap was dissected to create the flap bipedicle, and surgery was completed.

Result:
This procedure was used in 4 patients with malignant tumor of the external nose, and the flap survived perfectly in all patients. The postoperative esthetic outcome was also found to be good.

Conclusions:
This procedure does not increase the frequency of surgery, circulation in the flap is maintained, the flap pedicle on the supratrochlear artery can be made narrow, and flap thinning can be performed from the beginning. Coverage of an extensive defect is possible because a large flap can be excised, and satisfactory esthetic appearance can be obtained by matching with the esthetic unit. The delay technique for various flaps (not limited to forehead flap alone) should be considered an effective technique for the current treatment of malignant tumors.