bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and Electrical Properties of Zn1-xCrxO NTCR Nanoceramics Synthesized by High Energy Ball Milling
Authors: Das Bikram Keshari , Das Tanushree , Parashar Kajal , Parashar S.K.S , Kumar Rajeev , V Anupama . A. , Sahoo Balaram 
Published: February 2021

Abstract
Cr doped ZnO (x = 0-0.04) nanoceramics was successfully synthesized by high energy ball milling (HEBM) technique. The structural and electrical properties of the synthesized sample has been studied in detail. The doping of Cr into ZnO has been verified by X-ray diffraction (XRD) and also from the variation in structural parameters. Rietveld refinement XRD pattern of calcined sample showed the hexagonal wurtzite structure and it did not induce impurity phases. From the XRD, it has been confirm that maximum result confirms that up to 4 atomic% of Cr can be doped into ZnO. The strain of the sample reduced with increase in particle size. After sintering, there is a growth of particle size of Cr doped ZnO sample. The impedance spectroscopy data shows a single semicircle in the high frequency region corresponding to the bulk properties of the nanoceramic sample. The decrease in real part of the impedance with temperature suggests the NTCR behavior of the sample in the temperature range of 300-500 ºC. The temperature dependent relaxation phenomena are also observed for the synthesized ceramic sample at high temperature. Distributed relaxation time suggests that the relaxation in the synthesized samples is of non-Debye type. The equivalent electrical circuit of the semicircular pattern in the impedance spectrum of ZnO and Zn1-xCrxO nanoceramics sample is a parallel combination of bulk resistance (Rb) and bulk capacitance (Cb).
Circulating miRNA 27a and miRNA150-5p; a noninvasive approach to endometrial carcinoma
Authors: Ghazala Rasha , El-Attar Eman , Abouzeid Ziad 
Published: February 2021

Abstract
Background

The search for novel non-invasive biomarkers such as epigenetic molecular markers is new hope for common & burdensome cancers. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients.
Methods

Serum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy & 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction.
Results

Significant overexpression of both miRNA in patients (p < 0.001). At cutoffs 0.2872 & 1.02, miRNA 27a showed 100%sensitivity, specificity, positive & negative predictive values. miRNA150-5p showed 88.89%sensitivity, 100%specificity, 100%positive and 78.9%negative predictive values. Areas under curve were 1.0 for miRNA 27a, 0.982 for miRNA 150 performing much better than Ca125. miRNA 27a was significantly associated with type I endometroid endometrial cancer.
Conclusion

We suggest miRNA 27a and miRNA-150-5P as promising biomarkers of endometrial cancer possibly part of a miRNA panel for management.
Seismic-ionospheric perturbations in ionospheric TEC and plasma parameters associated with the 14 July 2019&nbsp;Mw7.2 Laiwui earthquake detected by the GPS and CSES
Authors: Wen Yuanzheng , Wang Guangxue , Tao Dan , Zong Jiayi , Zeren Zhima , Shen Xuhui 
Published: February 2021

Abstract
In this study, with cross-valid analysis of total electron content (TEC) data of the global ionospheric map (GIM) from GPS and plasma parameters data recorded by China Seismo-Electromagnetic Satellite (CSES), signatures of seismic-ionospheric perturbations related to the 14 July 2019 Mw 7.2 Laiwui earthquake were detected. After distinguishing the solar and geomagnetic activities, three positive temporal anomalies were found around the epicenter 1 day, 3 days and 8 days before the earthquake (14 July 2019) along with a negative anomaly 6 days after the earthquake, which also agrees well with the TEC spatial variations in latitude-longitude-time (LLT) maps. To further confirm the anomalies, the ionospheric plasma parameters (electron, O+ and He+ densities) recorded by the Langmuir probe (LAP) and Plasma Analyzer Package (PAP) onboard CSES were analyzed by using the moving mean method (MMM), which also presented remarkable enhancements along the orbits around the epicenter on day 2, day 4 and day 7 before the earthquake. To make the investigations more convincing, the disturbed orbits were compared with their corresponding four nearest revisiting orbits, whose results indeed indicate the existence of plasma parameters anomalies associated with the Laiwui earthquake. All these results illustrated that the GPS and CSES observed unusual ionospheric perturbations are highly associated with the Mw 7.2 Laiwui earthquake, which also strongly indicates the existence of pre-seismic ionospheric anomalies over the earthquake region.
Analysis of Construction Impact of A Large Diameter Shield Tunnelling Side-Crossing Viaduct Pile Foundations in Short Distance
Authors: Wang Jian , Wen Zhifang 
Published: February 2021

Abstract
The construction of shield tunneling through pile foundation will cause additional deformation and internal force of pile foundation, which will affect the safety and applicability of superstructure. Based on the engineering background of a large-diameter shield (Ф10.9 m) side crossing a viaduct, a three-dimensional finite element model for the construction of large-diameter shield side crossing viaduct pile foundations is established by using the finite element method. The reliability of the numerical model is verified by using the surface subsidence calculated by Peck formula as a reference. Based on this, the viaduct pier and piles additional response during the construction are developed, the analysis results shows that: Because the pile foot of the viaduct is located below the tunnel, the pier deformation during the shield construction is mainly in the transverse direction along the bridge; The deformation of piles is mainly lateral and vertical, and the lateral deformation is S-shaped, the deformation of piles near the tunnel axis is far away from the tunnel side, and the piles at this position has the maximum lateral deformation; The variation characteristics of the additional internal force of piles are similar to the additional deformation, the position of the maximum additional bending moment is consistent with the position of the maximum lateral deformation, while the maximum additional shear force of pile foundation is slightly lower than the tunnel axis. And the protection measures of elevated pile foundation proposed by the project are demonstrated, The calculation results show that the additional deformation of pier and piles has been significantly improved after taking the measures of stratum reinforcement, and its value is far lower than the standard control value.
Superoxide Anion Inhibits Intracellular Calcium Response in Porcine Airway Smooth Muscle Cells
Authors: Krishnan Ramesh , Deshpande Deepak , Kannan Mathur S. 
Published: February 2021

Abstract
BACKGROUND: Superoxide is implicated in lung disease, injury, and transplantation. In lung, many defense mechanisms, especially superoxide dismutase (SOD) and metallothionein, neutralize superoxide. Superoxide anions (O2-) have multiple effects on pulmonary parenchyma, altering cell proliferation, redox enzyme activation and smooth muscle contraction. Airway smooth muscle (ASM) contraction requires elevated intracellular Ca2+ ([Ca2+]i). [Ca2+]i release from intracellular stores also participates in contractile responses to multiple agonists. OBJECTIVE: We investigated the effects of O2- on agonist-stimulated [Ca2+]i responses in ASM cells. DESIGN/METHODS: Porcine ASM (PASM) cells were dissociated using collagenase and papain. Fura-2 AM-loaded PASM cells were used to examine [Ca2+]i release in response to acetylcholine (ACh), histamine, endothelin combined with lanthanum, and no Ca2+. RESULTS: In PASM cells, agonist exposure generated a biphasic Ca2+ response. Dihydrorhodamine-loaded cells exposed to xanthine and xanthine oxidase showed time-dependent generation of (O2-), which was inhibited by SOD. Pre-incubation with xanthine and xanthine oxidase for 15 or 45 min revealed significant inhibition of net [Ca2+]i responses to 100 nM and 1 M ACh and 50 M histamine. However, basal [Ca2+]i was similar in cells exposed to O2- and controls. Multiple agonists inhibited Ca2+ release in the presence of O2-. CONCLUSIONS: Superoxide impairs [Ca2+]i release and may interfere with the contractile mechanism in ASM cells. Alteration of a common signaling pathway may be involved in [Ca2+]i regulation. The effects of O2- were not likely due to cell damage since basal [Ca2+]i was unchanged. We need further experiments to identify the molecular targets of O2- in Ca2+ homeostasis.
Exploring Experiences and Needs of Spousal Carers of People with Behavioural variant Frontotemporal Dementia (bvFTD) including those with familial FTD (fFTD): A Qualitative Study
Authors: Tookey Sara , Greaves Caroline V. , Rohrer Jonathan D. , Desai Roopal , Stott Joshua 
Published: February 2021

Abstract
IntroductionCarers of people with frontotemporal dementia (FTD) experience greater challenges than carers of people with other dementias due to the younger age of onset and the challenging presentation of symptoms. The aim of the present study was to explore experiences of spousal carers of people with bvFTD, including those with the familial form of the disease (fFTD). MethodFourteen qualitative interviews were analysed using an inductive approach to Thematic Analysis to understand experiences of spousal carers of people with bvFTD including those with fFTD. ResultsFive main themes were identified including: a) The “Constant Battle” – A journey toward an FTD diagnosis, b) Shock, Relief and Fear – Challenges persist post diagnosis, c) The “Life Altering” impact – The loss of the spousal relationship and shifting roles, d) Adapting, Managing Symptoms and Receiving Carer Support, e) Lack of General Knowledge – Barriers to support. ConclusionsHealthcare professionals should be educated on the initial presentations of FTD, to enable carers and families receive timely diagnosis and appropriate support. Future research should investigate the impact of fFTD on carers and families, to explore positive or meaningful experiences in caring, as well as theory-driven research to identify helpful coping strategies for carers of people with FTD.
WITHDRAWN: Internet Gaming Disorder in Adolescence: Investigating Profiles and Associated Risk Factors
Authors: Macur Mirna , Pontes Halley M 
Published: February 2021

Abstract
Background: Since electronic gaming is particularly appealing to children and adolescents, they may be at greater risk for developing Internet Gaming Disorder (IGD). This study aimed to explore the characteristics of adolescents at risk of developing IGD because it is a relatively new disorder included in Diagnostic and Statistical Manual of Mental Disorders in 2013. Harmful consequences of disordered gaming have also been recognized by the World Health Organization that recently included ‘Gaming Disorder’ in the eleventh revision of the International Classification of Diseases. Additionally, this study also sought to encourage preventative initiatives in adolescence, when most addictions develop. Methods: A quantitative and nationally representative study was conducted in primary schools in Slovenia with eighth grade as the primary sampling unit (N = 1,071, Meanage = 13,44 years, SDage = 0.59). Psychometric test measuring IGD was administered to identify participants’ IGD risk and to compare ‘high risk’ and ‘low risk’ students in relation to free time activities, self-control, and parent-child relationship. T–test for independent samples was computed and multiple linear regression analysis performed to identify the most relevant predictors of IGD.Results: About 4.7% (n = 48) [95% CI: 3.4%-6.0%] of Slovenian adolescents were found to be at high risk of developing IGD. These were mostly boys (n = 42, 87.5%), and their preferred leisure activities involved more screen time activities (e.g., watching TV, playing video games, using social media). Moreover, high risk IGD participants showed significantly lower levels of self-control compared to low risk IGD participants and poorer understanding with their parents. Perceived satisfaction with life and mental health did not differ significantly between the two groups. Multiple linear regression analysis revealed five key predictors of IGD in adolescents: time spent gaming at weekends (ß = 0.27), male gender (ß = 0.20), low self-control (ß = -0.19), time spend gaming from Monday to Friday (ß = 0.11) and gaming as a frequent free time activity (ß = 0.11).Conclusion: Public health measures should target adolescents at risk of developing IGD in early age, because they are particularly drawn to video games and present greater IGD vulnerability.
Complex III Mitochondrial Leukoencephalopathy Masquerading Acute Demyelinating Syndrome Due to a Novel Variant in CYC1
Authors: Heidari Erfan , Rasoulinezhad Maryam , Pak Neda , Ashrafi Mahmoud Reza , Heidari Morteza , Banwell Brenda , Garshasbi Masoud , Tavasoli Ali Reza 
Published: February 2021

Abstract
Background Complex III (CIII) is the third out of five mitochondrial respiratory chain complexes residing at the mitochondrial inner membrane. The assembly of 10 subunits encoded by nuclear DNA and one by mitochondrial DNA result in the functional CIII which transfers electrons from ubiquinol to cytochrome c. Deficiencies of CIII are among the least investigated mitochondrial disorders and thus clinical spectrum of patients with mutations in CIII is not well defined. Resultswe report on a 10-year-old girl born to consanguineous Iranian parents presenting with acute neurological deficits reminiscent of acquired demyelination, mainly acute bilateral vision loss, who was ultimately confirmed to have a novel homozygous missense variant, c.949C>T; p.(Arg317Trp) in complex III of the mitochondrial chain. Sanger sequencing confirmed the segregation of this variant with disease in the family. ConclusionWe present a patient with a mitochondrial leukoencephalopathy due to complex III deficiency that manifested with features suggestive of an acquired demyelinating syndrome. The effect of this variant on the protein structure was shown in-silico. Our findings, not only expand the clinical spectrum due to defects in CYC1 gene but also highlight that mitochondrial disease should be considered in children with acute CNS demyelination.
Galacto-Oligosaccharides Improve Barrier Function and Relieve Colonic Inflammation via Modulating Mucosa-Associated Microbiota Composition in Lipopolysaccharides-Challenged Piglets
Authors: Gao Ren , Tian Shiyi , Wang Jing , Zhu Weiyun 
Published: February 2021

Abstract
BackgroundGalacto-oligosaccharides (GOS) have been shown to modulate the intestinal microbiota of suckling piglets to exert beneficial effects on intestinal function. However, the modulation of intestinal microbiota and intestinal function by GOS in intestinal inflammation injury models has rarely been reported. In this study, we investigated the effects of GOS on the colonic mucosal microbiota composition, barrier function and inflammatory response of lipopolysaccharides-challenged suckling piglets.Resultwe found that the colonic mucosa of LPS-challenged piglets was significantly injured and shedding, while the colonic mucosa of the LPS-GOS group piglets maintained its structure. GOS increased the relative abundance of Lactobacillus (P = 0.058), norank_f__Muribaculaceae and Romboutsia, and decreased the relative abundance of Alloprevotella, Campylobacter and Helicobacter in the colonic mucosa of LPS-challenged suckling piglets. In addition, GOS increased the concentrations of acetate, butyrate and total SCFAs in the colonic digesta of LPS-challenged suckling piglets. Increased SCFAs had beneficial effects on colonic barrier function and inflammatory status, including the enhanced protein expression of Claudin-1 and ZO-1 in the colonic mucosa of LPS-challenged suckling piglets, the decreased concentrations of interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and cluster of differentiation 14 (CD14), and the decreased relative expression of Toll-like receptor 4 (TLR4) and myeloid differentiation primary response 88 (MyD88).ConclusionsThese results suggested that GOS modulated the colonic mucosa-associated microbiota composition and improved the intestinal function of LPS-challenged suckling piglets.
epiLiver a novel tumor specific, high throughput and cost-effective blood test for specific detection of liver cancer (HCC)
Authors: Cheishvili David , Wong Chifat , Karim Mohammad , Kibria Mohammad , Jahan Nusrat , Das Pappu , Yousuf Md. Abul , Islam Md. Atikul , Das Dulal , Nor-E-Alam Sheikh , Szyf Moshe , Khan Wasif , Al-Mahtab Mammun 
Published: February 2021

Abstract
Robust cost effective and high-throughput tests for early detection of cancer in otherwise healthy people could potentially revolutionize public-health and the heavy personal and public burden of the morbidity and mortality from cancer. Several studies have delineated tumor specific DNA methylation profiles that could serve as biomarkers for early detection of Hepatocellular Carcinoma (HCC) as well as other cancers in liquid biopsies. Several published DNA methylation markers fail to distinguish HCC DNA from DNA from other tissues and other cancers that are potentially present in plasma. We describe a set of DNA methylation signatures in HCC that are “categorically” distinct from normal tissues and blood DNA methylation profiles. We develop a classifier combined of 4 CG sites that is sufficient to detect HCC in TCGA HCC data set at high accuracy. A single CG site at the F12 gene is sufficient to differentiate HCC samples from thousands of other blood samples, normal tissues and 31 tumors in the TCGA and Gene Expression Omnibus (GEO) data repository (n = 11,704). A “next generation sequencing”-targeted-multiplexed high-throughput assay was developed, which was used to examine in a clinical study plasma samples from HCC, chronic hepatitis B (CHB) patients and healthy controls (n = 398). The sensitivity for HCC detection was 84.5% at a specificity of 95% and AUC of 0.94. Applying this assay for routine follow up of people who are at high risk for developing HCC could have a significant impact on reducing the morbidity and mortality from HCC.
Research on Task-Offloading Decision Mechanism in Mobile Edge Computing based Internet of Vehicle
Authors: Cheng Jun , Guan Dejun 
Published: February 2021

Abstract
As a technology integrated with Internet of Things (IoT), mobile edge computing (MEC) can provide real-time and low latency services to the underlying network, and improve the storage and computation ability of the networks instead of central cloud infrastructure. In Mobile Edge Computing based Internet of Vehicle(MEC-IoV), the vehicle users can deliver their tasks to the associated MEC servers Based on offloading policy, which improves the resource utilization and computation performance greatly. However, how to evaluate the impact of uncertain interconnection between the vehicle users and MEC servers on offloading decision-making and avoid serious degradation of the offloading efficiency are important problems to be solved. In this paper, a task-offloading decision mechanism with particle swarm optimization for IoV-based edge computing is proposed. First, a mathematical model to calculate the computation offloading cost for cloud-edge computing system is defined. Then, the particle swarm optimization (PSO) is applied to convert the offloading of task into the process and obtain the optimal offloading strategy. Furthermore, to avoid falling into local optimization, the inertia weight factor is designed to change adaptively with the value of the objective function. The experimental results show that the proposed offloading strategy can effectively reduce the energy consumption of terminal devices while guarantee the service quality of users.
Health Burden and Economic Impacts Attributed to PM2.5 and O3 in China from 2010 to 2050 under Different Representative Concentration Pathway Scenarios
Authors: Wang Yiyi , Hu jianlin , Zhu Jia , Li Jingyi , Qin Momei , Liao Hong , Chen Kai , Wang Meng 
Published: February 2021

Abstract
Background: Quantifying future health burden attributed to fine particulate matters (PM2.5) and ozone (O3) in China is challenging when jointly accounting for emissions, climate and population changes. Future health burdens caused by PM2.5 and O3 in China remain largely understudied. Methods: In this paper, we used the Goddard Earth Observing System chemical transport model (GEOS-Chem) to project PM2.5 and O3 concentrations from 2010 to 2050 under four Representative Concentration Pathway scenarios (RCPs), then projected the PM2.5 and O3-related premature mortality and years of life lost (YLL) in this period. We then estimated the resulting economic burdens such as medical expenses (ME) and value of statistical life (VSL) in 2010-2050 attributed to the burdens of disease on PM2.5 and O3.Results: Compared to the targeted year 2050, we found that PM2.5 concentrations changed between -31.5% to 14.5% since 2010, resulted in -13.5% to 9.4% change in PM2.5-related mortality and -25.7% to 0.6% change in YLL across all the RCPs scenarios. For O3, the concentrations varied -13.3% to 3.7% by 2050, contributing to -26.9% to 13.1% change in O3-related mortality and -48.8% to 4.0% change in YLL. The lowest health impacts occurred in the RCP4.5 scenario by 2050 for both pollutants. In 2010, the ME caused by PM2.5 and O3 was $6.3-6.5 billion, and the VSL was $112.1-114.9 billion, accounting for 2.9-3.0% of the total GDP ($3874 billion). By 2050, ME and VSL will change from -19.7% to 17.5% and from -65.5% to 136.6%, respectively.Conclusion: This study suggested that future PM2.5 and O3 under certain RCP scenarios can have large health and economic benefits. However, given that the future population will always be higher than the baseline in 2010, more aggressive air pollution mitigation measures are needed for China.