bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adding Well-Being to Ageing: Family Transitions as Determinants of Later-Life Socio-Emotional and Economic Well-Being
Authors: Zoutewelle-Terovan Mioara , Muller Joanne S. 
Published: April 2021

AbstractThis chapter focuses on adult family-related experiences and the manner in which they affect later-life socio-emotional and economic well-being (loneliness, employment, earnings). Particularly innovative is the investigation of these relationships in a cross-national perspective. Results from two studies conducted by the authors of this chapter within the CONOPP project show that deviations from family-related social customs differently impact socio-emotional and economic well-being outcomes as there is: (a) a non-normative family penalty for loneliness (individuals who never experience cohabitation/marriage or parenthood or postpone such events are the loneliest); and (b) a non-normative family bonus for women’s economic outcomes (single and/or childless women have the highest earnings). Moreover, analyses revealed that European countries differ considerably in the manner in which similar family-related experiences affect later-life well-being. For example, childlessness had a stronger negative impact on loneliness in Eastern Europe than in Western Europe and the observed heterogeneity could be explained by culturally-embedded family-related values and norms (childless individuals in countries placing stronger accent on ‘traditional’ family values are lonelier compared to childless individuals in less ‘traditionalistic’ nations). In terms of economic outcomes, results show that the lower the female labor force participation during child-rearing years, the more substantial the differences in later-life employment and income between women with different family life trajectories.
Spacetime as a quantum circuit
Authors: Chandra A. Ramesh , de Boer Jan , Flory Mario , Heller Michal P. , Hörtner Sergio , Rolph Andrew 
Published: April 2021

Abstract
We propose that finite cutoff regions of holographic spacetimes represent quantum circuits that map between boundary states at different times and Wilsonian cutoffs, and that the complexity of those quantum circuits is given by the gravitational action. The optimal circuit minimizes the gravitational action. This is a generalization of both the “complexity equals volume” conjecture to unoptimized circuits, and path integral optimization to finite cutoffs. Using tools from holographic $$ T\overline{T} $$
T

T
¯

, we find that surfaces of constant scalar curvature play a special role in optimizing quantum circuits. We also find an interesting connection of our proposal to kinematic space, and discuss possible circuit representations and gate counting interpretations of the gravitational action.
A machine learning approach to distinguish between knees without and with osteoarthritis using MRI-based radiomic features from tibial bone
Authors: Hirvasniemi Jukka , Klein Stefan , Bierma-Zeinstra Sita , Vernooij Meike W. , Schiphof Dieuwke , Oei Edwin H. G. 
Published: April 2021

Abstract
Objectives
Our aim was to assess the ability of semi-automatically extracted magnetic resonance imaging (MRI)–based radiomic features from tibial subchondral bone to distinguish between knees without and with osteoarthritis.

Methods
The right knees of 665 females from the population-based Rotterdam Study scanned with 1.5T MRI were analyzed. A fast imaging employing steady-state acquisition sequence was used for the quantitative bone analyses. Tibial bone was segmented using a method that combines multi-atlas and appearance models. Radiomic features related to the shape and texture were calculated from six volumes of interests (VOIs) in the proximal tibia. Machine learning–based Elastic Net models with 10-fold cross-validation were used to distinguish between knees without and with MRI Osteoarthritis Knee Score (MOAKS)–based tibiofemoral osteoarthritis. Performance of the covariate (age and body mass index), image features, and combined covariate + image features models were assessed using the area under the receiver operating characteristic curve (ROC AUC).

Results
Of 665 analyzed knees, 76 (11.4%) had osteoarthritis. An ROC AUC of 0.68 (95% confidence interval (CI): 0.60–0.75) was obtained using the covariate model. The image features model yielded an ROC AUC of 0.80 (CI: 0.73–0.87). The model that combined image features from all VOIs and covariates yielded an ROC AUC of 0.80 (CI: 0.73–0.87).

Conclusion
Our results suggest that radiomic features are useful imaging biomarkers of subchondral bone for the diagnosis of osteoarthritis. An advantage of assessing bone on MRI instead of on radiographs is that other tissues can be assessed simultaneously.

Key Points
• Subchondral bone plays a role in the osteoarthritis disease processes.
• MRI radiomics is a potential method for quantifying changes in subchondral bone.
• Semi-automatically extracted radiomic features of tibia differ between subjects without and with osteoarthritis.
Frequency, clinical presentation and outcome of vigilance impairment in patients with uni- and bilateral ischemic infarction of the paramedian thalamus
Authors: Fritsch Merve , Villringer Kersten , Ganeshan Ramanan , Rangus Ida , Nolte Christian H. 
Published: April 2021

AbstractIschemic stroke of the paramedian thalamus is a rare differential diagnosis in sudden altered vigilance states. While efforts to describe clinical symptomatology exist, data on the frequency of paramedian thalamic stroke as a cause of sudden impaired vigilance and on accompanying clinical signs and outcome are scarce. We retrospectively analyzed consecutive patients admitted to a tertiary stroke center between 2010 and 2019 diagnosed with paramedian thalamic stroke. We evaluated frequency of vigilance impairment (VI) due to paramedian thalamic stroke, accompanying clinical signs and short-term outcome in uni- versus bilateral paramedian lesion location. Of 3896 ischemic stroke patients, 53 showed a paramedian thalamic stroke location (1.4%). VI was seen in 29/53 patients with paramedian thalamic stroke and in 414/3896 with any stroke (10.6%). Paramedian thalamic stroke was identified as causal to VI in 3.4% of all patients with initial VI in the emergency department and in 0.7% of all ischemic stroke patients treated in our center. Accompanying clinical signs were detected in 21 of these 29 patients (72.4%) and facilitated a timely diagnosis. VI was significantly more common after bilateral than unilateral lesions (92.0% vs. 21.4%; p < 0.001). Patients with bilateral paramedian lesions were more severely affected, had longer hospital stays and more frequently required in-patient rehabilitation. Paramedian thalamic lesions account for about 1 in 15 stroke patients presenting with impaired vigilance. Bilateral paramedian lesion location is associated with worse stroke severity and short-term outcome. Paying attention to accompanying clinical signs is of importance as they may facilitate a timely diagnosis.
Towards understanding Cameraria ohridella (Lepidoptera: Gracillariidae) development: effects of microhabitat variability in naturally growing horse-chestnut tree canopy
Authors: Łaszczyca Piotr , Nakonieczny Mirosław , Kędziorski Andrzej , Babczyńska Agnieszka , Wiesner Marta 
Published: April 2021

AbstractDwelling intensity of horse-chestnut miner (Cameraria ohridella) larvae in various leaves insolation and temperature was measured to determine whether this pest’s development follows a predictable pattern or depends more on local microenvironment conditions. Mines growing on leaves of mature host plants (Aesculus hippocastanum L.) in their natural conditions were photographed for two consecutive generations of the pest and in two separated vegetation periods. Apart from meteorological data obtained from the nearest station, the temperature of intact and mined parts of sun-exposed and shaded leaf blades was measured at various daytimes throughout the experiment. Obtained sets of digital data were analysed and combined to model mine area growth as a function of degree-days sum by adopting of Verhulst logistic equation. We showed the predictive potential of our model based on experimental data, and it may be useful in the scheduling of pest control measures in natural conditions. Our analyses also revealed that despite significant differences in microenvironment conditions depending on mines’ insolation, the horse-chestnut miner larvae could partially compensate for them and complete their development at similar endpoints expressed as the cumulative sum of degree-days. We conclude that computer-aided analysis of photographic documentation of leaf-miner larval growth followed by mathematical modelling offers a noninvasive, reliable, and inexpensive alternative for monitoring local leaf-miners populations.
Exploring big data-driven innovation in the manufacturing sector: evidence from UK firms
Authors: Babu Mujahid Mohiuddin , Rahman Mahfuzur , Alam Ashraful , Dey Bidit Lal 
Published: April 2021

AbstractAlthough innovation from analytics is surging in the manufacturing sector, the understanding of the data-driven innovation (DDI) process remains a challenge. Drawing on a systematic literature review, thematic analysis and qualitative interview findings, this study presents a seven-step process to understand DDI in the context of the UK manufacturing sector. The findings discuss the significance of critical seven-step in DDI, ranging from conceptualisation to commercialisation of innovative data products. The results reveal that the steps in DDI are sequential, but they are all interlinked. The proposed seven-step DDI process with solid evidence from the UK manufacturing and research implications based on dynamic capability theory, institutional theory and TOE framework establish the building blocks for future studies and industry practice.
Creating Shared Value Through an Inclusive Development Lens: A Case Study of a CSV Strategy in Ghana’s Cocoa Sector
Authors: Ollivier de Leth David , Ros-Tonen Mirjam A. F. 
Published: April 2021

AbstractDespite the widespread popularity of the Creating Shared Value (CSV) discourse, its ‘business case’ and ‘win–win’ rhetoric remain problematic. This paper adds an inclusive development perspective to the debate, arguing that analysing CSV strategies through an inclusivity lens contributes to a better operationalisation of societal value; makes tensions and contradictions between economic and societal value explicit and uncovers processes of inclusion, exclusion and adverse inclusion. We illustrate this by analysing Nestlé’s CSV strategy in its cocoa supply chains in Ghana based on content analysis of company documents, interviews with value chain actors and stakeholders, and focus groups with farmers. We ask how Nestlé frames and implements its CSV discourse in practice and how this relates to the social, relational and environmental dimensions of inclusive development. Findings show how the company addresses inclusive development dimensions in its corporate discourse, practices and business operations, and what trade-offs it faces. We then unmask the inherent tension between business objectives and societal interests and explain why the scope, issues addressed and societal impacts of CSV remain constrained. We conclude that CSV can help reduce a company’s impact on some persistent societal issues, but that its contribution to transformational change remains limited because the need to uphold competitive advantages and short-term financial performance narrows its ability to address all inclusivity dimensions. Legislation mandating responsible business conduct and due diligence can reduce this inherent tension by levelling the playing field between companies addressing inclusivity issues vis-à-vis those who do not.
Artistic Freedom or the Hamper of Equality? Exploring Ethical Dilemmas in the Use of Artistic Freedom in a Cultural Organization in Sweden
Authors: Johansson Janet Zhangyan , Lindström Sol Sofia 
Published: April 2021

AbstractWith this paper, from the perspective of ethics at the workplace, we problematize the taken-for-granted assumptions embedded in the use of artistic freedom in creative processes. Drawing on the notion of inequality regimes (e.g. Acker, 2006) and using empirical material from a performing arts organization in Sweden, we explore how the assumptions of artistic freedom facilitate and legitimize the emergence of inequality regimes in invisible and subtle manners. Our findings indicate that non-reflexive interpretations of the concept of artistic freedom result in ethical dilemmas that impact the organization's pursuits of equality work. The aesthetic ethics oriented around the notion of ‘art for the sake of art’ tends to camouflage the centralization of aesthetic authority in processes where formal hierarchical structures are missing. Consequently, asymmetrical power relations between the Directors, actors, and producers are legitimized. Ethics of quality of art and that of the social ideal of equality have been constructed as dichotomic notions indicating that aesthetic ethics of art can only be preserved at the expense of social objectives of equality. We argue that the current interpretative practices of ‘artistic freedom’ in some cultural organizations add little value of ethics to the freedom of expressing artistic opinions and in achieving the social ideal of equality but lead to the emergence of inequality regimes in the artistic work processes.
Bioaccessible arsenic in soil of thermal areas of Viterbo, Central Italy: implications for human health risk
Authors: Rimondi V. , Costagliola P. , Lattanzi P. , Catelani T. , Fornasaro S. , Medas D. , Morelli G. , Paolieri M. 
Published: April 2021

AbstractThermal waters near the city of Viterbo (Central Italy) are known to show high As contents (up to 600 µg/l). Travertine is precipitated by these waters, forming extended plateau. In this study, we determine the As content, speciation and bioaccessibility in soil and travertine samples collected near a recreational area highly frequented by local inhabitants and tourists to investigate the risk of As exposure through accidental ingestion of soil particles. (Pseudo)total contents in the studied soils range from 17 to 528 mg/kg, being higher in soil developed on a travertine substrate (197 ± 127 mg/kg) than on volcanic rocks (37 ± 13 mg/kg). In travertines, most As is bound to the carbonatic fraction, whereas in soil the semimetal is mostly associated with the oxide and residual fractions. Accordingly, bioaccessibility (defined here by the simplified bioaccessibility extraction test, SBET; Oomen et al., 2002.) is maximum (up to 139 mg/kg) for soil developed on a travertine substrate, indicating a control of calcite dissolution on As bioaccessibility. On the other hand, risk analysis suggests a moderate carcinogenic risk associated with accidental soil ingestion, while dermal contact is negligible. By contrast, ingestion of thermal water implies a higher carcinogenic and systemic health risk.
Vegetable nitrate intake, blood pressure and incident cardiovascular disease: Danish Diet, Cancer, and Health Study
Authors: Bondonno Catherine P. , Dalgaard Frederik , Blekkenhorst Lauren C. , Murray Kevin , Lewis Joshua R. , Croft Kevin D. , Kyrø Cecilie , Torp-Pedersen Christian , Gislason Gunnar , Tjønneland Anne , Overvad Kim , Bondonno Nicola P. , Hodgson Jonathan M. 
Published: April 2021

AbstractWhether the vascular effects of inorganic nitrate, observed in clinical trials, translate to a reduction in cardiovascular disease (CVD) with habitual dietary nitrate intake in prospective studies warrants investigation. We aimed to determine if vegetable nitrate, the major dietary nitrate source, is associated with lower blood pressure (BP) and lower risk of incident CVD. Among 53,150 participants of the Danish Diet, Cancer, and Health Study, without CVD at baseline, vegetable nitrate intake was assessed using a comprehensive vegetable nitrate database. Hazard ratios (HRs) were calculated using restricted cubic splines based on multivariable-adjusted Cox proportional hazards models. During 23 years of follow-up, 14,088 cases of incident CVD were recorded. Participants in the highest vegetable nitrate intake quintile (median, 141 mg/day) had 2.58 mmHg lower baseline systolic BP (95%CI − 3.12, − 2.05) and 1.38 mmHg lower diastolic BP (95%CI − 1.66, − 1.10), compared with participants in the lowest quintile. Vegetable nitrate intake was inversely associated with CVD plateauing at moderate intakes (~ 60 mg/day); this appeared to be mediated by systolic BP (21.9%). Compared to participants in the lowest intake quintile (median, 23 mg/day), a moderate vegetable nitrate intake (median, 59 mg/day) was associated with 15% lower risk of CVD [HR (95% CI) 0.85 (0.82, 0.89)]. Moderate vegetable nitrate intake was associated with 12%, 15%, 17% and 26% lower risk of ischemic heart disease, heart failure, ischemic stroke and peripheral artery disease hospitalizations respectively. Consumption of at least ~ 60 mg/day of vegetable nitrate (~ 1 cup of green leafy vegetables) may mitigate risk of CVD.
Exploiting the transit timing capabilities of Ariel
Authors: Borsato Luca , Nascimbeni Valerio , Piotto Giampaolo , Szabó Gyula 
Published: April 2021

AbstractThe Transit Timing Variation (TTV) technique is a powerful dynamical tool to measure exoplanetary masses by analysing transit light curves. We assessed the transit timing performances of the Ariel Fine Guidance Sensors (FGS1/2) based on the simulated light curve of a bright, 55 Cnc, and faint, K2-24, planet-hosting star. We estimated through a Markov-Chain Monte-Carlo analysis the transit time uncertainty at the nominal cadence of 1 second and, as a comparison, at a 30 and 60-s cadence. We found that at the nominal cadence Ariel will be able to measure the transit time with a precision of about 12s and 34s, for a star as bright as 55 Cnc and K2-24, respectively. We then ran dynamical simulations, also including the Ariel timing errors, and we found an improvement on the measurement of planetary masses of about 20-30% in a K2-24-like planetary system through TTVs. We also simulated the conditions that allow us to detect the TTV signal induced by an hypothetical external perturber within the mass range between Earth and Neptune using 10 transit light curves by Ariel.
Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Carry MicroRNA-671 to Alleviate Myocardial Infarction Through Inactivating the TGFBR2/Smad2 Axis
Authors: Wang Xue , Zhu Yuhai , Wu Chengcheng , Liu Wennan , He Yujie , Yang Qing 
Published: April 2021

Abstract
Mesenchymal stem cells (MSCs) and their derived extracellular vesicles have been reported as promising tools for the management of heart disease. The aim of this study was to explore the function of adipose-derived MSCs (adMSCs)-derived exosomes (Exo) in the progression of myocardial infarction (MI) and the molecules involved. Mouse cardiomyocytes were treated with oxygen-glucose deprivation (OGD) to mimic an MI condition in vitro. The adMSCs-derived Exo were identified and administrated into the OGD-treated cardiomyocytes, and then the viability and apoptosis of cells, and the secretion of fibrosis- and inflammation-related cytokines in cells were determined. Differentially expressed microRNAs (miRNAs) in cells after Exo treatment were screened using a microarray analysis. The downstream molecules regulated by miR-671 were explored through bioinformatic analysis. Involvements of miR-671 and transforming growth factor beta receptor 2 (TGFBR2) in the exosome-mediated events were confirmed by rescue experiments. A murine model with MI was induced and treated with Exo for functional experiments in vivo. Compared to phosphate-buffered saline treatment, the Exo treatment significantly enhanced viability while reduced apoptosis of cardiomyocytes, and in reduced myocardial fibrosis and inflammation both in vitro and in vivo. miR-671 was significantly upregulated in cells after Exo treatment. Downregulation of miR-671 blocked the protective functions of Exo. miR-671 targeted TGFBR2 and suppressed phosphorylation of Smad2. Artificial downregulation of TGFBR2 enhanced viability of the OGD-treated cardiomyocytes. This study suggested that adMSC-derived exosomal miR-671 directly targets TGFBR2 and reduces Smad2 phosphorylation to alleviate MI-like symptoms both in vivo and in vitro.
Veganism, Moral Motivation and False Consciousness
Authors: Pickett Susana 
Published: April 2021

AbstractDespite the strength of arguments for veganism in the animal rights literature, alongside environmental and other anthropocentric concerns posed by industrialised animal agriculture, veganism remains only a minority standpoint. In this paper, I explore the moral motivational problem of veganism from the perspectives of moral psychology and political false consciousness. I argue that a novel interpretation of the post-Marxist notion of political false consciousness may help to make sense of the widespread refusal to shift towards veganism. Specifically, the notion of false consciousness fills some explanatory gaps left by the moral psychological notion ofakrasia, often understood to refer to a weakness of will. Central to my approach is the idea that animal exploitation is largely systemic and the assumption that moral motivation is inseparable from moral thinking. In this light, the primary obstacle to the adoption of veganism arises not so much from a failure to put genuine beliefs into action, but rather in a shared, distorted way of thinking about animals. Thus, common unreflective objections to veganism may be said to be manifestations of false consciousness.
Latex Metabolome of Euphorbia Species: Geographical and Inter-Species Variation and its Proposed Role in Plant Defense against Herbivores and Pathogens
Authors: Salomé-Abarca Luis Francisco , Gođevac Dejan , Kim Min Sun , Hwang Geum-Sook , Park Sang Cheol , Jang Young Pyo , Van Den Hondel Cees A. M. J. J. , Verpoorte Robert , Klinkhamer Peter G. L. , Choi Young Hae 
Published: April 2021

AbstractBased on the hypothesis that the variation of the metabolomes of latex is a response to selective pressure and should thus be affected differently from other organs, their variation could provide an insight into the defensive chemical selection of plants. Metabolic profiling was used to compare tissues of threeEuphorbiaspecies collected in diverse regions. The metabolic variation of latexes was much more limited than that of other organs. In all the species, the levels of polyisoprenes and terpenes were found to be much higher in latexes than in leaves and roots of the corresponding plants. Polyisoprenes were observed to physically delay the contact of pathogens with plant tissues and their growth. A secondary barrier composed of terpenes in latex and in particular, 24-methylenecycloartanol, exhibited antifungal activity. These results added to the well-known role of enzymes also present in latexes, show that these are part of a cooperative defense system comprising biochemical and physical elements.
Validation of EFFTRAN for efficiency transfer to distant geometries and volume sources
Authors: Ramebäck H. , Jonsson S. , Vidmar T. 
Published: April 2021

AbstractThe efficiency transfer procedure from a geometry where a volume source was placed directly on the endcap of a germanium detector to three different distant geometries was carried out using the EFFTRAN code. One of these distant geometries included absorbers consisting of poly(methyl methacrylate). The efficiency transfer to this geometry therefore had to be realized as a two-stage transfer, since a direct efficiency transfer is not possible using EFFTRAN in such a case. Efficiency transfer to all three distant geometries yielded results which can be considered as fit-for-purpose in e.g. most of the applications of gamma ray spectrometry.