bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful outcome and 1‐year follow‐up after partial iliectomy with limb preservation in a cat with pelvic osteosarcoma
Authors: Goffart Laura Maria , Mehl Jan‐Niklas , Reif Ullrich 
Published: August 2021

AbstractA 16‐month‐old male neutered cat was referred due to a history of right hindlimb lameness over several days. Radiography by the referring veterinarian revealed an osteolytic lesion at the right ilial wing. Haematology and blood chemistry were unremarkable besides borderline values of alkaline phosphatase (74 U/L). For further workup, thoracic, abdominal and pelvic computed tomography (CT) were performed. CT confirmed the presence of an osteolytic mass with additional osteoneogenesis in the right ilial wing and indicated no evidence of metastatic disease. Resection of the mass was carried out using partial iliectomy with preservation of the limb. Histopathology confirmed the mass as osteosarcoma. Follow‐up was accomplished by radiographic re‐check of the ilium every few months. On the 1‐year follow‐up, the cat was clinically healthy with no signs of lameness. Follow‐up radiographies of the pelvis up until the time of writing this report showed no signs of tumour recurrence.
Ronda: Real-Time Data Provision, Processing and Publication for Open Data
Authors: Kirstein Fabian , Bacher Dario , Bohlen Vincent , Schimmler Sonja 
Published: August 2021

AbstractThe provision and dissemination of Open Data is a flourishing concept, which is highly recognized and established in the government and public administrations domains. Typically, the actual data is served as static file downloads, such as CSV or PDF, and the established software solutions for Open Data are mostly designed to manage this kind of data. However, the rising popularity of the Internet of things and smart devices in the public and private domain leads to an increase of available real-time data, like public transportation schedules, weather forecasts, or power grid data. Such timely and extensive data cannot be used to its full potential when published in a static, file-based fashion. Therefore, we designed and developed Ronda - an open source platform for gathering, processing and publishing real-time Open Data based on industry-proven and established big data and data processing tools. Our solution easily enables Open Data publishers to provide real-time interfaces for heterogeneous data sources, fostering more sophisticated and advanced Open Data use cases. We have evaluated our work through a practical application in a production environment.
The relationship between personal intrinsic factors towards a design problem and the degree of novelty and circularity
Authors: Ruiz-Pastor Laura , Chulvi Vicente , Mulet Elena , Royo Marta 
Published: August 2021

AbstractThe aim of this work is to determine how personal intrinsic factors towards a design problem are related to novelty and circularity. A deeper understanding of this relationship will be a valuable aid when it comes to making an adequate selection of design teams. The factors studied are the level of the designer's motivation, relevance, knowledge and affinity with regard to the design problem. To this end, a study was conducted with 35 novice designers, organised in groups of between two and five members. Each group had to propose a conceptual solution to two different design problems. Novelty was assessed using the SAPPhIRE causality model (which stands for State–Action–Part–Phenomenon–Input–oRgan–Effect) and the Circular Economy Toolkit was applied to measure circularity. The results show that as motivation, level of knowledge, perception of relevance and affinity for the problem increase, the solution displays greater novelty and less circularity, although for circularity, the difference is not statistically significant.
Kombinierter Suizid: Methode nach Kusch und Kopfschuss – ein Fallbericht
Authors: Weber A. , Rabl W. 
Published: August 2021

ZusammenfassungDie gleichzeitige Anwendung mehrerer Methoden beim Suizid wird als „kombinierter Suizid“ bezeichnet. Vorgestellt wird ein Fall, bei dem zunächst alles auf einen Suizid mittels Schusswaffe hindeutet. Die chemisch-toxikologische Analyse ergibt den Nachweis von Benzodiazepinen und einer potenziell letalen Chloroquinkonzentration im Blutserum, was als Methode nach Kusch bezeichnet wird und mit einer Handlungsunfähigkeit einhergehen kann. Die Kombination von Chloroquin mit Diazepam kann aber, in Abhängigkeit von der Dosierung, auch dazu führen, dass die Handlungsfähigkeit erhalten bleibt und auch hohe Chloroquinkonzentrationen überlebt werden. Der vorgestellte Fall soll die potenziellen Wechselwirkungen dieser Wirkstoffe verdeutlichen.
Interface Automata for Shared Memory
Authors: Schinko Ayleen , Vogler Walter , Gareis Johannes , Nguyen N. Tri , Lüttgen Gerald 
Published: August 2021

AbstractInterface theories based on Interface Automata (IA) are formalisms for the component-based specification of concurrent systems. Extensions of their basic synchronization mechanism permit the modelling of data, but are studied in more complex settings involving modal transition systems or do not abstract from internal computation. In this article, we show how de Alfaro and Henzinger’s original IA theory can be conservatively extended by shared memory data, without sacrificing simplicity or imposing restrictions. Our extension IA for shared Memory (IAM) decorates transitions with pre- and post-conditions over algebraic expressions on shared variables, which are taken into account by IA’s notion of component compatibility. Simplicity is preserved as IAM can be embedded into IA and, thus, accurately lifts IA’s compatibility concept to shared memory. We also provide a ground semantics for IAM that demonstrates that our abstract handling of data within IA’s open systems view is faithful to the standard treatment of data in closed systems.
Comparison of Postoperative Pain and Analgesic Requirements Between Laparoscopic and Open Hernia Repair in Children
Authors: Bruce Eilidh S. , Hotonu Sesi A. , McHoney Merrill 
Published: August 2021

AbstractBackgroundThis study analyses the impact of anaesthetic blockade and intraperitoneal local anaesthetic infiltration on paediatric laparoscopic inguinal hernia repair.MethodA retrospective review of paediatric laparoscopic hernia repairs versus open repairs. Anaesthetic blockade, analgesic consumption and postoperative pain scores were compared between groups.Results155 children underwent laparoscopic repair, 150 underwent open repairs. Median age was 7.2 months (16 days–14 years) in the laparoscopic group, 6 months (17 days–13 years) in the open group. Anaesthetic blockade varied significantly; 62.7% of open cases had caudal blockade compared to 21.6% laparoscopic (p < 0.001). A subset of laparoscopic patients had peritoneal local anaesthetic infiltration. 10.1% of laparoscopic cases required recovery analgesia, compared to 1.3% of open cases (p = 0.001). Postoperative analgesic consumption was significantly higher in the laparoscopic group. Peritoneal infiltration reduced analgesic consumption in the laparoscopic group (p = 0.038). Age < 2 was associated with use of caudal (p < 0.001), which reduced analgesic consumption.ConclusionsLaparoscopy was associated with increased use of recovery analgesia. Caudal reduced the need for rescue and postoperative analgesia. Intraperitoneal infiltration of local anaesthetic is associated with reduced postoperative analgesia in laparoscopy. In suitable patients undergoing laparoscopic surgery, combination caudal and peritoneal infiltration may prove a useful adjunctive analgesic strategy.
Magnetic sphincter augmentation device removal: surgical technique and results at medium-term follow-up
Authors: Bona Davide , Saino Greta , Mini Emanuele , Lombardo Francesca , Panizzo Valerio , Cavalli Marta , Bonitta Gianluca , Campanelli Giampiero , Aiolfi Alberto 
Published: August 2021

Abstract
Background
The magnetic sphincter augmentation (MSA) device has become a common option for the treatment of gastroesophageal reflux disease (GERD). Knowledge of MSA-related complications, indications for removal, and techniques are puzzled. With this study, we aimed to evaluate indications, techniques for removal, surgical approach, and outcomes with MSA removal.

Methods
This is an observational singe-center study. Patients were followed up regularly with endoscopy, pH monitoring, and assessed for specific gastroesophageal reflux disease health-related quality of life (GERD-HRQL) and generic short-form 36 (SF-36) quality of life.

Results
Five patients underwent MSA explant. Four patients were males and the median age was 47 years (range 44–55). Heartburn, epigastric/chest pain, and dysphagia were commonly reported. The median implant duration was 46 months (range 31–72). A laparoscopic approach was adopted in all patients. Intraoperative findings included normal anatomy (40%), herniation in the mediastinum (40%), and erosion (20%). The most common anti-reflux procedures were Dor (n = 2), Toupet (n = 2), and anterior partial fundoplication (n = 1). The median operative time was 145 min (range 60–185), and the median hospital length of stay was 4 days (range 3–6). The median postoperative follow-up was 41 months (range 12–51). At the last follow-up, 80% of patients were off PPI; the GERD-HRQL and SF-36 questionnaire were improved with DeMeester score and esophageal acid exposure normalization.

Conclusion
The MSA device can be safely explanted through a single-stage laparoscopic procedure. Tailoring a fundoplication, according to preoperative patient symptoms and intraoperative findings, seems feasible and safe with a promising trend toward improved symptoms and quality of life.
Long-term oncological outcomes after laparoscopic parenchyma-sparing redo liver resections for patients with metastatic colorectal cancer: a European multi-center study
Authors: Barkhatov Leonid , Aghayan Davit L. , Scuderi Vincenzo , Cipriani Federica , Fretland Åsmund A. , Kazaryan Airazat M. , Ratti Francesca , Armstrong Thomas , Belli Andrea , Dagher Ibrahim , Belli Giulio , Aldrighetti Luca , Hilal Mohammad Abu , Troisi Roberto I. , Edwin Bjørn 
Published: August 2021

Abstract
Background
Laparoscopic redo resections for colorectal metastases are poorly investigated. This study aims to explore long-term results after second, third, and fourth resections.

Material and methods
Prospectively updated databases of primary and redo laparoscopic liver resections in six European HPB centers were analyzed. Procedure-related overall survival after first, second, third, and fourth resections were evaluated. Furthermore, patients without liver recurrence after first liver resection were compared to those with one redo, two or three redo, and patients with palliative treatment for liver recurrence after first laparoscopic liver surgery. Survival was calculated both from the date of the first liver resection and from the date of the actual liver resection. In total, 837 laparoscopic primary and redo liver resections performed in 762 patients were included (630 primary, 172 first redo, 29 second redo, and 6 third redo). Patients were bunched into four groups: Group 1—without hepatic recurrence after primary liver resection (n = 441); Group 2—with liver recurrence who underwent only one laparoscopic redo resection (n = 154); Group 3—with liver recurrence who underwent two laparoscopic redo resections (n = 29); Group 4—with liver recurrence who have not been found suitable for redo resections (n = 138).

Results
No significant difference has been found between the groups in terms of baseline characteristics and surgical outcomes. Rate of positive resection margin was higher in the group with palliative recurrence (group 4). Five-year survival calculated from the first liver resection was 67%, 62%, 84%, and 7% for group 1, 2, 3, and 4, respectively. Procedure-specific 5-year overall survival was 50% after primary laparoscopic liver resection, 52% after the 1st reoperation, 52% after the 2nd, and 40% after the 3rd reoperation made laparoscopic.

Conclusions
Multiple redo recurrences can be performed laparoscopically with good long-term results. Liver recurrence does not aggravate prognosis as long as the patient is suitable for reoperation.
Role of new digital technologies and telemedicine in pulmonary rehabilitation
Authors: Fekete Monika , Fazekas-Pongor Vince , Balazs Peter , Tarantini Stefano , Nemeth Anna N. , Varga Janos Tamas 
Published: August 2021

SummaryBackgroundAsthma and chronic obstructive pulmonary diseases are conditions characterized by a variable progression. Some individuals experience longer asymptomatic periods while others acute worsening periods and/or exacerbations triggered by symptom multiplication factors. Medications are adjusted to the patients’ respiratory function, self-assessment of health and emerging certain physical changes. A more effective treatment may be applied by real-time data registered during the patient’s everyday life.Aim and methodsIntroducing new modern digital technology in pulmonary rehabilitation (PR) to help tracking the patients’ medication, thus we systematically reviewed the latest publications on telemedicine and pulmonary telerehabilitation.ConclusionThe use of the latest digital technologies in PR is very exciting and offers great opportunities while treating patients affected by specific conditions. On the one hand, adherence to medication can be improved in patients with chronic respiratory diseases by using these new state of the art devices; on the other hand, digital devices will also be able to monitor various physiological parameters of patients during their usual everyday activities. Data can be stored on a smartphone and shared with the provider. Relying on this information, physicians will be able to tailor medications and dosage to the specific needs of individual patients. Telerehabilitation may be a sustainable solution to the growing burden of chronic respiratory disease worldwide. However, PR must keep its cornerstones, such as education and motivations, which are most successful when conducted in person. Many issues remain to be resolved in the future, e.g. cybersecurity while using smart devices since they offer unique opportunities for PR.
Extreme learning machine versus classical feedforward network
Authors: Markowska-Kaczmar Urszula , Kosturek Michał 
Published: August 2021

AbstractOur research is devoted to answering whether randomisation-based learning can be fully competitive with the classical feedforward neural networks trained using backpropagation algorithm for classification and regression tasks. We chose extreme learning as an example of randomisation-based networks. The models were evaluated in reference to training time and achieved efficiency. We conducted an extensive comparison of these two methods for various tasks in two scenarios:$$\bullet$$∙using comparable network capacity and$$\bullet$$∙using network architectures tuned for each model. The comparison was conducted on multiple datasets from public repositories and some artificial datasets created for this research. Overall, the experiments covered more than 50 datasets. Suitable statistical tests supported the results. They confirm that for relatively small datasets, extreme learning machines (ELM) are better than networks trained by the backpropagation algorithm. But for demanding image datasets, like ImageNet, ELM is not competitive to modern networks trained by backpropagation; therefore, in order to properly address current practical needs in pattern recognition entirely, ELM needs further development. Based on our experience, we postulate to develop smart algorithms for the inverse matrix calculation, so that determining weights for challenging datasets becomes feasible and memory efficient. There is a need to create specific mechanisms to avoid keeping the whole dataset in memory to compute weights. These are the most problematic elements in ELM processing, establishing the main obstacle in the widespread ELM application.
Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration
Authors: Gómez de San José Nerea , Massa Federico , Halbgebauer Steffen , Oeckl Patrick , Steinacker Petra , Otto Markus 
Published: August 2021

AbstractThe diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms are still poorly characterised. Reliable quantification of synaptic damage is crucial to understand the pathophysiology of neurodegeneration, to track disease status and to obtain prognostic information. Neuronal pentraxins (NPTXs) are extracellular scaffolding proteins emerging as potential biomarkers of synaptic dysfunction in neurodegeneration. They are a family of proteins involved in homeostatic synaptic plasticity by recruiting post-synaptic receptors into synapses. Recent research investigates the dynamic changes of NPTXs in the cerebrospinal fluid (CSF) as an expression of synaptic damage, possibly related to cognitive impairment. In this review, we summarise the available data on NPTXs structure and expression patterns as well as on their contribution in synaptic function and plasticity and other less well-characterised roles. Moreover, we propose a mechanism for their involvement in synaptic damage and neurodegeneration and assess their potential as CSF biomarkers for neurodegenerative diseases.
50 Years on, w(h)ither the Ramsar convention? A case of institutional drift
Authors: Bridgewater Peter , Kim Rakhyun E. 
Published: August 2021

AbstractWetlands have declined in area and quality at an accelerating pace in the last 50 years. Yet, the last 50 years is when international attention has been focussed on wetlands through the Ramsar Convention. An analysis of how the convention has evolved over the past 50 years suggests it has been drifting away from its original mandate in a maladaptive manner, and this drift is a problem for achieving its original objectives. A review of the strategic plans of the convention revealed two key conditions for institutional drifting and the associated lack of success. The first condition lies in its unique situation as a non-UN convention, which reduces the convention’s visibility and interactivity with other biodiversity-related conventions, agencies, or programmes. The second condition is an increasing number of conventions dealing with biodiversity issues, all forcing the Ramsar Convention to seek different roles in an increasingly competitive institutional landscape. A more effective future for the convention arguably lies in reasserting its original mandate, but with cognisance of the changed environmental pressures of the twenty-first century. While this would narrow its increasingly broad focus, such a reorientation will allow wetlands and waterfowl to start a track to recovery, backed by active and focused Contracting Parties in a renewed international convention on wetland conservation, management, and sustainable use.
Cholesterol lowering drug use and breast cancer survival: the Multiethnic Cohort Study
Authors: Moksud Nafeesa , Loo Lenora W. M. , Yang Juan , Huang Chiung-Yu , Haiman Christopher A. , Le Marchand Loïc , Wilkens Lynne R. , Cheng Iona 
Published: August 2021

Abstract
Purpose
Prior studies conducted primarily in white populations have suggested that pre-diagnostic cholesterol lowering drugs (CLDs) improved survival among women with breast cancer (BC). However, this association had not been well characterized in diverse racial/ethnic populations. We investigated whether pre-diagnostic CLD use is associated with all-cause and BC-specific mortality among female BC cases of the Multiethnic Cohort (MEC).

Methods
CLD use was ascertained through questionnaires administered in 2003–2008. A total of 1448 incident BC cases were identified by linkage to SEER cancer registries in Hawaii and California from 2003 to 2014. Multivariable Cox regression was conducted to estimate hazard ratios (HR) and 95% confidence intervals (CI) of the associations of pre-diagnostic CLD use with all-cause and BC-specific mortality, adjusting for tumor characteristics, first course of treatment, health behaviors, co-morbidities, and demographics. Subgroup analyses by stage and hormone receptor status were conducted for all-cause mortality.

Results
There were 224 all-cause and 87 BC-specific deaths among the 1448 BC cases during a median follow-up of 4.5 years after diagnosis. Women with BC who ever used CLDs had a 27% lower hazard of all-cause mortality (HR 0.73, 95% CI 0.54–0.98) and 17% lower hazard of BC-specific mortality (HR 0.83, 95% CI 0.49–1.39) compared to never users. CLD use reduced mortality among women with advanced-stage tumors and hormone receptor-positive breast tumors (HR 0.54 95% CI 0.33–0.90; HR 0.69, 95% CI 0.48–0.99, respectively).

Conclusion
These findings demonstrate an improved survival associated with CLD use prior to diagnosis in a multiethnic population of women with BC.
Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method
Authors: Lukac Iva , Wyatt Paul G. , Gilbert Ian H. , Zuccotto Fabio 
Published: August 2021

AbstractWater molecules play a crucial role in protein–ligand binding, and many tools exist that aim to predict the position and relative energies of these important, but challenging participants of biomolecular recognition. The available tools are, in general, capable of predicting the location of water molecules. However, predicting the effects of their displacement is still very challenging. In this work, a linear-scaling quantum mechanics-based approach was used to assess water network energetics and the changes in network stability upon ligand structural modifications. This approach offers a valuable way to improve understanding of SAR data and help guide compound design.
On some relations between ideals of nowhere dense sets in topologies on positive integers
Authors: Nowik Andrzej , Szyszkowska Paulina 
Published: August 2021

AbstractWe examine the ideals of nowhere dense sets in three topologies on the set of positive integers, namely Furstenberg’s, Rizza’s and the common division topology. We mainly concentrate on inclusions between these ideals, we present a diagram showing these and we explore all possible inclusions between them. We present a formula for the closure of a set in the common division topology. We answer a question posed by Kwela and Nowik (Topol Appl. 248:149–163, 2018) by constructing a set in $${{\mathcal {I}}}_G {\setminus } ({{\mathcal {I}}}_K \cup {{\mathcal {I}}}_F)$$

I
G

\

(

I
K

∪

I
F

)

. Therefore, the main diagram of comparison between the ideals of nowhere dense sets in various topologies from the article by M. Kwela and A. Nowik is completed.