bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen and Progesterone Therapy and Meningiomas
Authors: Hage Mirella , Plesa Oana , Lemaire Isabelle , Raffin Sanson Marie Laure 
Published: December 2021

Abstract
Meningiomas are common intracranial tumors with a female predominance. Their etiology is still poorly documented. The role of sexual hormones has long been evoked, and data have been conflicting across studies. However, a dose-dependent relationship between the incidence and growth of meningiomas and hormonal treatment with the progestin cyproterone acetate (CPA) has recently been established. CPA-associated meningiomas seem to be mainly located in the anterior and middle skull base, are more likely to be multiple, may harbor P1K3CA mutations in up to one-third of cases, and are more common with a longer duration of treatment. A similar but lower risk of meningiomas has been recently reported with the use of chlormadinone acetate and nomegestrol acetate as progestin treatments. Concerning hormonal replacement therapy (HRT) in menopausal patients, evidence from epidemiological studies seem to favor an increased risk of meningiomas in treated patients although a recent study failed to show an increased growth of meningiomas in HRT treated vs nontreated patients. Until larger studies are available, it seems wise to recommend avoiding HRT in patients with meningiomas. Evidence from published data does not seem to support an increased risk of meningiomas with oral contraceptive oral contraceptive (OR) use. Data are too scarce to conclude on fertility treatments. Based on studies demonstrating the expression of hormonal receptors in meningiomas, therapies targeting these receptors have been tried but have failed to show an overall favorable clinical outcome in meningioma treatment.
Is There a Role for Biomarkers in Surveillance of Pancreatic Neuroendocrine Neoplasms in Von Hippel-Lindau Disease?
Authors: Naber Myrthe R , Ahmad Saya , Verrijn Stuart Annemarie A , Giles Rachel H , Valk Gerlof D , van Leeuwaarde Rachel S 
Published: December 2021

Abstract
Von Hippel-Lindau (VHL) disease is an autosomal dominant disorder characterized by the development of multi-organ neoplasms. Among the manifestations of VHL are pancreatic neuroendocrine neoplasms (panNENs). In order to detect these lesions in a timely manner, patients are enrolled in a surveillance program, in accordance with the several existing VHL guidelines. However, these guidelines remain unclear about the role of biomarkers in diagnosing panNENs, despite the benefits a biomarker may offer regarding early detection of new lesions, thereby possibly limiting radiation exposure, and improving quality of life. The aim is to determine which biomarkers might be available in VHL patients and to assess their clinical relevance in diagnosing panNENs in VHL patients.
We searched the databases of PubMed/Medline, Embase, and Web of Science to identify relevant articles. Seven studies assessing the diagnostic or prognostic value of biomarkers were included. The results from these studies were conflicting. Since no evident association between VHL-related panNENs and biomarkers was established in studies with larger study populations, currently biomarkers do not play a significant role in early detection or follow-up for panNENs in VHL patients. The absence of evidence underscores the need for specific research to address this unmet need.
Real-Time MRI–Guided Stereotactic Aspiration of Spontaneous Intracerebral Hematoma: A Preclinical Feasibility Study
Authors: Patra Devi P. , Welz Matthew E. , Turcotte Evelyn L. , Pandey Rajesh , Vij Kamal , Daly Max , Rabon Matthew , Korszen Stephanie , Zhou Yuxiang , Halpin Brooke , Marchese Marco L. , Syal Arjun , Krishna Chandan , Bendok Bernard R. 
Published: December 2021

BACKGROUND:
Minimally invasive surgical techniques have reinvigorated the role of surgical options for spontaneous intracranial hematomas; however, they are limited by the lack of real-time feedback on the extent of hematoma evacuation.

OBJECTIVE:
To describe the development of a MRI-guided catheter-based aspiration system, the ClearPoint Pursuit Neuroaspiration Device (ClearPoint Neuro) and validation in phantom models.

METHODS:
In this preclinical experimental trial, 8 phantom brains with skull models were created to simulate an intracranial hematoma with 2 clot sizes, 30 cc (small clot) and 60 cc (large clot). After registration, the aspiration catheter (Pursuit device) was aligned to the desired planned trajectory. The aspiration of the clot was performed under real-time MRI scan in 3 orthogonal views. The primary end point was reduction of the clot volume to less than 15 cc or 70% of the original clot volume.

RESULTS:
Successful completion of clot evacuation was achieved in all models. The average postaspiration clot volume was 9.5 cc (8.7 cc for small clots and 10.2 cc for large clots). The average percentage reduction of clot volume was 76.3% (range 58.7%-85.2%). The average total procedure time (from frame registration to final postaspiration clot assessment) was 50 min. The average aspiration time was 6.9 min.

CONCLUSION:
This preclinical trial confirms the feasibility and efficacy of MRI-guided aspiration under real-time image guidance in simulation models for intracranial hematoma. Clinical use of the system in patients would further validate its efficacy and safety.
Endoscopic Endonasal Excision of a Ventral Exophytic Brainstem Glioma: A Technical Case Report
Authors: Patel Biren Khimji , Sreenath P. R. , George Tobin , Shah Shreykumar P. , Easwer H. V. , Nair Prakash 
Published: December 2021

BACKGROUND AND IMPORTANCE:
Ventral midbrain glioma is an extremely rare lesion in adults. The endoscopic endonasal approach is potentially a better alternative to transcranial approach for this challenging lesion and has not been described in the literature.

CLINICAL PRESENTATION:
A 22-yr-old woman previously operated through an interhemispheric approach for ventral midbrain glioma with extension in the suprasellar cistern presented with severe headache and diplopia. Imaging revealed an increase in size of the residual lesion. The tumor was resected by using an extended endonasal approach. The patient had improvement in her diplopia with no endocrine complication.

CONCLUSION:
This case demonstrates the surgical technique of endoscopic endonasal resection of a ventral midbrain glioma.
A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis
Authors: Rommelfanger Megan K. , MacLean Adam L. 
Published: December 2021

ABSTRACT
Cells do not make fate decisions independently. Arguably, every cell-fate decision occurs in response to environmental signals. In many cases, cell-cell communication alters the dynamics of the internal gene regulatory network of a cell to initiate cell-fate transitions, yet models rarely take this into account. Here, we have developed a multiscale perspective to study the granulocyte-monocyte versus megakaryocyte-erythrocyte fate decisions. This transition is dictated by the GATA1-PU.1 network: a classical example of a bistable cell-fate system. We show that, for a wide range of cell communication topologies, even subtle changes in signaling can have pronounced effects on cell-fate decisions. We go on to show how cell-cell coupling through signaling can spontaneously break the symmetry of a homogenous cell population. Noise, both intrinsic and extrinsic, shapes the decision landscape profoundly, and affects the transcriptional dynamics underlying this important hematopoietic cell-fate decision-making system.
This article has an associated ‘The people behind the papers’ interview.
Boehmite-derived Aluminum Oxide Catalyst for a Continuous Intramolecular Aldol Condensation of 2,5-Hexanedione to 3-Methyl-2-cyclopentenone in a Liquid-flow Reactor System
Authors: Nishimura Shun , Le Son Dinh , Asai Yusaku , Takahashi Natsuki , Endo Maho , Ohmatsu Shintaro 
Published: December 2021

Abstract
After thermal treatment of boehmite at higher than 600 °C and 1100 °C, the crystal phase transformation from AlOOH to γ-Al2O3 and/or δ-Al2O3 and the further transformations to the mixed phases of θ-Al2O3 and α-Al2O3, are respectively observed. Genesis of γ-Al2O3 (and/or δ-Al2O3) emphasizes the reactivity on an intramolecular aldol condensation of 2,5-hexanedione to 3-methyl-2-cyclopentenone (MCP) and its recyclability: approx. 70% yield with more than 80% selectivity for MCP generation are achieved in a liquid-flow reactor system for 9 h.
Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex
Authors: Zhou Yong-Sheng , Meng Fan-Cheng , Cui Yue , Xiong Yan-Lu , Li Xu-Yang , Meng Fan-Bo , Niu Zi-Xuan , Zheng Jia-Xin , Quan Ya-Qi , Wu Sheng-Xi , Han Yong , Xu Hui 
Published: December 2021

ABSTRACT

Purpose
Clinical studies found that regular aerobic exercise has analgesic and antianxiety effects; however, the underlying neural mechanisms remain unclear. Multiple studies have suggested that regular aerobic exercise may exert brain-protective effects by promoting the release of serotonin, which may be a pain modulator. Anterior cingulate cortex (ACC) is a key brain area for pain information processing, receiving dense serotonergic innervation. As a result, we hypothesized that exercise may increase the release of serotonin in the ACC, thus improving pain and anxiety behaviors.

Methods
Integrative methods were used, including behavioral, electrophysiological, pharmacological, biochemical, and genetic approaches, to explore the effects of regular aerobic exercise and the underlying neural mechanisms.

Results
Regular aerobic exercise in the form of voluntary wheel running for 30 min daily for 15 d showed significant effectiveness in relieving pain and concomitant anxiety in complete Freund’s adjuvant–induced chronic inflammation pain models. c-Fos staining and multielectrode array recordings revealed alterations in neuronal activities and synaptic plasticity in the ACC. Moreover, systemic pharmacological treatment with 4-chloro-dl-phenylalanine (PCPA) to deplete endogenous serotonin and local delivery of serotonin to the ACC revealed that exercise-related serotonin release in the ACC bidirectionally modulates pain sensitization and anxiety behaviors by modulating synaptic plasticity in the ACC. Furthermore, we found that 5-HT1A and 5-HT7 receptors mediated the serotonin modulation effects under conditions of regular aerobic exercise through local infusion of a selective antagonist and shRNA in the ACC.

Conclusions
Our results reveal that regular aerobic exercise can increase serotonin release and modulate synaptic plasticity in the ACC, ultimately improving pain and concomitant anxiety behaviors through the functions of the 5-HT1A and 5-HT7 receptors.
A comprehensive high cost drugs dataset from the NHS in England - An OpenSAFELY-TPP Short Data Report
Authors: Rowan Anna , Bates Chris , Hulme Will J. , Evans David , Davy Simon , A Kennedy Nicholas , Galloway James , E Mansfield Kathryn , Bechman Katie , Matthewman Julian , Yates Mark , Brown Jeremy , Schultze Anna , Norton Sam , J. Walker Alex , E. Morton Caroline , Bhaskaran Krishnan , T. Rentsch Christopher , Williamson Elizabeth , Croker Richard , Bacon Seb , Hickman George , Ward Tom , Green Amelia , Fisher Louis , J Curtis Helen , Tazare John , M. Eggo Rosalind , Inglesby Peter , Cockburn Jonathan , I. McDonald Helen , Mathur Rohini , YS Wong Angel , Forbes Harriet , Parry John , Hester Frank , Harper Sam , J Douglas Ian , Smeeth Liam , A Tomlinson Laurie , W Lees Charlie , Evans Stephen J W , Smith Catherine , M. Langan Sinéad , Mehkar Amir , MacKenna Brian , Goldacre Ben 
Published: December 2021

Background: At the outset of the COVID-19 pandemic, there was no routine comprehensive hospital medicines data from the UK available to researchers. These records can be important for many analyses including the effect of certain medicines on the risk of severe COVID-19 outcomes. With the approval of NHS England, we set out to obtain data on one specific group of medicines, “high-cost drugs” (HCD) which are typically specialist medicines for the management of long-term conditions, prescribed by hospitals to patients. Additionally, we aimed to make these data available to all approved researchers in OpenSAFELY-TPP. This report is intended to support all studies carried out in OpenSAFELY-TPP, and those elsewhere, working with this dataset or similar data. Methods: Working with the North East Commissioning Support Unit and NHS Digital, we arranged for collation of a single national HCD dataset to help inform responses to the COVID-19 pandemic. The dataset was developed from payment submissions from hospitals to commissioners. Results: In the financial year (FY) 2018/19 there were 2.8 million submissions for 1.1 million unique patient IDs recorded in the HCD. The average number of submissions per patient over the year was 2.6. In FY 2019/20 there were 4.0 million submissions for 1.3 million unique patient IDs. The average number of submissions per patient over the year was 3.1. Of the 21 variables in the dataset, three are now available for analysis in OpenSafely-TPP: Financial year and month of drug being dispensed; drug name; and a description of the drug dispensed. Conclusions: We have described the process for sourcing a national HCD dataset, making these data available for COVID-19-related analysis through OpenSAFELY-TPP and provided information on the variables included in the dataset, data coverage and an initial descriptive analysis.
Progeny testing of Pinus sylvestris L. of seed orchard in different environmental conditions
Authors: Mazhula Olga , Fuchylo Yaroslav , Hayda Yuriy , Kharytonov Mykola , Matkovcka Svitlana 
Published: December 2021

Evaluation of the progeny test of plus trees of Scots pine - a necessary condition for determining the prospects the use of improved seeds in different environmental conditions. The paper presents the results of the study of the progeny test of groups of clones of plus trees of Scots pine selected according to certain characteristics in Northern Steppe and South Forest-Steppe of Ukraine. Analysis of results showed: a significant improvement in the growth rates of the all testing progenies of seed orchard in the better climatic and soil conditions of South Forest-Steppe between the ages of 3 and 10 years. At the same time 4 out of 5 studied progenies worsened their growth indicators relative to local control at the age of 3 to 26 years in less optimal climatic and soil conditions of Northern Steppe. The leader in the steppe conditions was the progeny of a fraction of three clones, which had the highest seed productivity. The selection of the fastest growing clones and the rejection of the slowest growing ones had a positive effect on the growth of progenies of seed orchards at both test points.
Student Well-Being in the Context of Erik Allardt’s Theory of Welfare and Urie Bronfenbrenner’s Ecological Systems Theory of Development
Authors: Łukasik Izabella Maria 
Published: December 2021

Samopoczucie ucznia w szkole decyduje o jego sukcesie edukacyjnym oraz funkcjonowaniu w grupie rówieśników w przestrzeni szkoły. Celem niniejszego artykułu stało się wskazanie na możliwość wykorzystania koncepcji dobrobytu Erika Allardta dla określenia wymiarów samopoczucia ucznia w szkole przy uwzględnieniu kontekstów środowiskowych. Wyodrębniono wskaźniki samopoczucia ucznia, umocowane w systemie ekologicznym Bronfenbrennera, które pozwolą na określenie interesującego badawczo przedmiotu. Nie można pominąć osobistej oceny sytuacji szkolnej w kontekście indywidualnych preferencji, skoro samopoczucie rzutuje na realizację wyzwań związanych z różnorodnymi zadaniami edukacyjnymi. Właściwe rozpoznanie trudności pozwala na wkroczenie z działaniem interwencyjnym w te miejsca, które wymagają naprawy. Zaproponowane wskaźniki samopoczucia mogą służyć jako itemy zastosowane w badaniach kwestionariuszowych. Pozwalają na wielopłaszczyznowy ogląd uwarunkowań, wpływających na odczucie dobrostanu ucznia. Właściwe rozpoznanie problemu daje szansę podjęcia działań korekcyjnych.
Oddziaływanie pandemii COVID-19 na finanse jednostek samorządu terytorialnego
Authors: Łubina Joanna 
Published: December 2021

Recesja spowodowana pandemią COVID-19 oraz wprowadzonym lockdownem była ważnym czynnikiem oddziałującym na stan finansów samorządu terytorialnego w latach 2020–2021. Pandemia wymusiła konieczność dynamicznych zmian i dostosowania się jednostek samorządu terytorialnego do nowej rzeczywistości. W artykule podjęto próbę oceny wpływu pandemii COVID-19 na sposób wydatkowania środków publicznych przez jednostki samorządu terytorialnego. Zaprezentowano szanse i zagrożenia wywołane pandemią COVID-19 na funkcjonowanie jednostek samorządu terytorialnego podyktowane zmieniającym się ustawodawstwem w zakresie dochodów i wydatków, na szczeblu gmin, powiatów i województw.
Nature in Progress – Tocqueville and the Transformation of Natural Law
Authors: Smrcz Ádám 
Published: December 2021

Hayden White famously claimed that Tocqueville’s emplotment of history was „tragic” by genre, and his ideological implications were „radical”. The aim of this paper is to argue that this interpretation is correct, but that our arguments will be based on a subject entirely ignored by White: Tocqueville’s meagre scarce remarks on nature and natural law. According to their commonsensical definition, natural laws must „stem from God, nature, or reason”, but this relationship in Tocqueville is highly problematic. As I intend to prove, Tocqueville probably did acknowledge the existence of natural laws, and even intended to describe their resulting obligations (as in the case of what virtuous deeds are, or what humanity is etc.), but the way he defined nature herself suggests that the precise content of such obligations cannot be settled easily. Hence, according to our claim, a disturbing tension can be observed between the way Tocqueville attempted to describe certain natural laws, and the way he defined natural laws in general. Furthermore, this tension is analogous with the aforementioned friction between the author’s personal convictions and his scientific conclusions.
Virtual Reality? Investment Consultants’ Claims About Their Own Performance
Authors: Cookson Gordon , Jenkinson Tim , Jones Howard , Martinez Jose Vicente 
Published: December 2021

Investment consultants market their services by claiming their fund manager recommendations add significant value. Using nonpublic data sourced from investment consultants and the UK regulator, we find no such evidence, but identify several practices that explain their exaggerated claims: comparisons to benchmarks instead of peers, inclusion of simulated and backfilled returns, use of investment horizons that allow losers to be forgotten, and unexplained exclusions of products from the analysis. Consultants do not fully disclose their methodology to investors, who therefore cannot verify or reliably compare their performance. This paper was accepted by Haoxiang Zhu, finance. Supplemental Material: Data and the internet appendix are available at https://doi.org/10.1287/mnsc.2021.4218 .
Factors influencing women's knowledge at scheduled postnatal visits: a multi-centre study in Kakamega, Kenya
Authors: Kiragu Charles , Osero Justus SO , Wanyoro Anthony K 
Published: December 2021

Background/aims Postnatal care is offered to mothers and their babies from birth and across the postnatal period. Visits are spread over the postnatal period, and a minimum of four visits is recommended. In many studies, postnatal visits in Africa have been reported to be low compared to antenatal visits. As a result of low postnatal visits, mothers are not able to utilise postnatal care services, resulting in delayed detection of and interventions for maternal and neonatal health problems, leading to high rates of maternal and neonatal morbidity and mortality. In Kenya, only 53% of mothers attend postnatal clinics; in Kakamega county, only 34% of mothers attend. This study aimed to establish factors influencing postnatal knowledge among mothers in selected hospitals in Kakamega, Kenya. Methods The study was a descriptive cross-sectional study involving 320 postnatal mothers recruited from four sub-counties. Systematic sampling was used to select eligible study participants. Data were collected using questionnaires that assessed the participants' knowledge of postnatal care in terms of what postnatal care is, recommended postnatal care, when to attend a clinic and the services offered at postnatal care clinics. The data were entered into a database and analysed using the Chi-squared test to assess how sociodemographic and socioeconomic characteristics were associated with knowledge of postnatal care. Results The majority of participants (73.1%) had poor or no knowledge of postnatal care and 89.7% had poor or no knowledge on when postnatal visits should be carried out. Most postnatal mothers (71.9%) received postnatal health information from health workers. Occupation (P<0.000), income (P<0.000), transport (P<0.000) and time taken to travel to hospital (P=0.034) were significantly associated with postnatal knowledge. Conclusions Knowledge on postnatal care is poor among postnatal mothers in Kakamega. The majority of participants obtained postnatal care information from health workers, and so it is recommended that Kakamega establishes other strategies for giving information on postnatal care, such as pamphlets to mothers.
Frequency tuning for broadband terahertz emission from two-color laser-induced air plasma
Authors: Wang Linzheng , Zhang Zhelin , Xia Tianhao , Chen Yanping , Sheng Zhengming 
Published: December 2021

Effective manipulation of broadband terahertz emission, especially on spectrum tuning, is of great importance for many applications. We demonstrate a method to realize frequency tuning of terahertz emissions from two-color laser-induced air plasmas. The terahertz central frequency is switched from 0.56 to 0.82 THz by changing the polarization state of the fundamental wave with a quarter-wave plate. Based on numerical simulation, it is found that this frequency tuning is due to the birefringence effect induced by the fundamental wave on the second harmonic inside the filament, which leads to a discrepancy on the polarization chirality of the two-color laser components. Two-color lasers with opposite chirality will emit terahertz radiation with higher central frequency compared to two-color lasers with the same chirality at moderate laser intensity.