bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population
Authors: Zhen Shihan , Cai Ruoxin , Yang Xuelian , Ma Yanan , Wen Deliang 
Published: November 2021

BackgroundGalectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity and has been highlighted as a potential mediator of adipose inflammation in obesity. In this study, we aimed to identify whether GAL-3BP is a novel biological marker for metabolic syndrome (MetS).MethodsThe biochemical and anthropometric variables of the 570 participants in this study were evaluated using standard procedures. Their serum GAL-3BP levels were measured using enzyme-linked immunosorbent assay (ELISA), while the association between the glycoprotein and MetS was analyzed using multiple logistic regression analyses. Moreover, an experimental MetS model was established. The expression of GAL-3BP in serum and adipose tissue was measured using ELISA and western blotting. Lipid accumulation was determined with the use of immunohistochemistry and immunofluorescent staining.ResultsThe serum GAL-3BP level was found to be positively associated with MetS. The logistic regression analyses demonstrated that participants expressing the upper levels of GAL-3BP were more likely to develop MetS than those expressing less of the glycoprotein (OR = 2.39, 95%CI: 1.49, 3.83). The association between the serum GAL-3BP level and MetS was found preferentially in postmenopausal women (OR = 2.30, 95%CI: 1.31, 4.05). In addition, GAL-3BP was increased in the serum and visceral adipose tissue (VAT) of high fat diet (HFD) mice. Moreover, GAL-3BP was highly expressed in VAT macrophages.ConclusionsThis study confirmed serum GAL-3BP to be positively associated with MetS, highlighting it as a useful biological marker of MetS in Chinese participants.
Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer
Authors: Lee Jun Choul , Song Byong-Sop , Kang Young Mi , Kim Yu-Ri , Kang Yea Eun , Lee Ju Hee , Shong Minho , Yi Hyon-Seung 
Published: November 2021

ContextThyroid-stimulating hormone (TSH) suppression is recommended to reduce tumor recurrence following surgery for differentiated thyroid cancer (DTC). However, prolonged subclinical hyperthyroidism caused by levothyroxine treatment has deleterious effects on various organs.ObjectiveTo evaluate the relationships of TSH concentration with muscle mass, muscle strength, and physical performance related to sarcopenia in patients with DTC undergoing TSH suppression following surgery.MethodsWe studied 134 patients of &gt;60 years who were undergoing TSH suppression therapy following surgery for DTC. We evaluated muscle mass and muscle function-related parameters and diagnosed sarcopenia using the threshold for Asian people.ResultsThe participants were 68.3 ± 7.2 years old and 36/134 (26.9%) were diagnosed with sarcopenia. They were allocated to high-TSH and low-TSH groups using a threshold concentration of 0.40 μU/mL, and grip strength was significantly lower in the low-TSH group. The data were further analyzed according to age and sex, and in the low-TSH group, male participants and those of &lt;70 years were found to have significantly lower grip strength.ConclusionsLow-TSH concentrations is associated with low grip strength, and this is most pronounced in individuals of &lt;70 years of age. Therefore, muscle function should be considered an adverse effect of TSH suppression in patients with DTC who undergo TSH suppression therapy, especially in men of &lt;70 years.
The Hydrolyzed Mil-88B(Fe) With Improved Surface Area for High-Capacity Lithium Ion Battery
Authors: Guo Mingxuan , Li Haibo 
Published: November 2021

In this work, Mil-88B(Fe) is modified by a facile hydrolysis method for high-performance lithium ion battery (LIB). The hydrolyzed Mil-88B(Fe) [H-Mil-88B(Fe)] heritages the spindle-like shape of Mil-88B(Fe) and forms a porous structure, which possesses relatively high specific surface area (427.86 m2 g−1). It is 15 times higher than that of pristine Mil-88B(Fe). As anode for LIB, it reaches to high specific capacity of 600.1 mAh g−1 after 100 cycles at 100 mA g−1, while it is 312.5 mAh g−1 for pure Mil-88B(Fe). Furthermore, the kinetic analysis on i=avb reveals that the b value of H-Mil-88B(Fe) is 0.888, which suggests the mixed contribution from the diffusion and capacity reactions. Furthermore, the capacitance contribution fractions of H-Mil-88B(Fe) are 47.6%, 53.28%, 56.88%, 74.68%, and 69.14% at the sweep rate of 0.2, 0.4, 0.6, 0.8, 1.0 mV s−1, respectively, demonstrating a capacitance-dominated charge storage process at fast charging rates.
Basic Predictive Risk Factors for Cytokine Storms in COVID-19 Patients
Authors: Shcherbak Sergey G. , Anisenkova Anna Yu , Mosenko Sergei V. , Glotov Oleg S. , Chernov Alexander N. , Apalko Svetlana V. , Urazov Stanislav P. , Garbuzov Evgeny Y. , Khobotnikov Dmitry N. , Klitsenko Olga A. , Minina Evdokia M. , Asaulenko Zakhar P. 
Published: November 2021

ObjectiveA critical role in coronavirus disease 2019 (COVID-19) pathogenesis is played by immune dysregulation that leads to a generalized uncontrolled multisystem inflammatory response, caused by overproduction of proinflammatory cytokines, known as “a cytokine storm” (CS), strongly associated with a severe course of disease. The aim of this study is to identify prognostic biomarkers for CS development in COVID-19 patients and integrate them into a prognostic score for CS-associated risk applicable to routine clinical practice.Materials and MethodsThe authors performed a review of 458 medical records from COVID-19 patients (241 men and 217 women aged 60.0 ± 10.0) who received treatment in the St. Petersburg State Budgetary Institution of Healthcare City Hospital 40 (City Hospital 40, St. Petersburg), from Apr. 18, 2020 to Nov. 21, 2020. The patients were split in two groups: one group included 100 patients with moderate disease symptoms; the other group included 358 patients with progressive moderately severe, severe, and extremely severe disease. The National Early Warning Score (NEWS) score was used alongside with clinical assessment, chest computed tomographic (CT) scans, electrocardiography (ECG), and lab tests, like ferritin, C-reactive protein (CRP), interleukin (IL)-6, lactate dehydrogenase (LDH), and D-dimer.ResultsThe basic risk factors for cytokine storms in COVID-19 patients are male gender, age over 40 years, positive test result for replicative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, absolute lymphocyte count, dynamics in the NEWS score, as well as LDH, D-dimer, ferritin, and IL-6 levels. These clinical and instrumental findings can be also used as laboratory biomarkers for diagnosis and dynamic monitoring of cytokine storms. The suggested prognostic scale (including the NEWS score dynamics; serum IL-6 greater than 23 pg/ml; serum CRP 50 mg/L or greater; absolute lymphocyte count less than 0.72 × 109/L; positive test result for replicative coronavirus (SARS-CoV-2) RNA; age 40 years and over) is a useful tool to identify patients at a high risk for cytokine storm, requiring an early onset of anti-inflammatory therapy.
Serum N-Glycome Diversity in Teleost and Chondrostrean Fishes
Authors: Aoki Kazuhiro , Kumagai Tadahiro , Ranzinger René , Bergmann Carl , Camus Alvin , Tiemeyer Michael 
Published: November 2021

Recent advances in carbohydrate chemistry, chemical biology, and mass spectrometric techniques have opened the door to rapid progress in uncovering the function and diversity of glycan structures associated with human health and disease. These strategies can be equally well applied to advance non-human health care research. To date, the glycomes of only a handful of non-human, non-domesticated vertebrates have been analyzed in depth due to the logistic complications associated with obtaining or handling wild-caught or farm-raised specimens. In contrast, the last 2 decades have seen advances in proteomics, glycoproteomics, and glycomics that have significantly advanced efforts to identify human serum/plasma biomarkers for various diseases. In this study, we investigated N-glycan structural diversity in serum harvested from five cultured fish species. This biofluid is a useful starting point for glycomic analysis because it is rich in glycoproteins, can be acquired in a sustainable fashion, and its contents reflect dynamic physiologic changes in the organism. Sera acquired from two chondrostrean fish species, the Atlantic sturgeon and shortnose sturgeon, and three teleost fish species, the Atlantic salmon, Arctic char, and channel catfish, were delipidated by organic extraction and the resulting protein-rich preparations sequentially treated with trypsin and PNGaseF to generate released N-glycans for structural analysis. Released N-glycans were analyzed as their native or permethylated forms by nanospray ionization mass spectrometry in negative or positive mode. While the basic biosynthetic pathway that initiates the production of glycoprotein glycan core structures is well-conserved across the teleost fish species examined in this study, species-specific structural differences were detected across the five organisms in terms of their monosaccharide composition, sialylation pattern, fucosylation, and degree of O-acetylation. Our methods and results provide new contributions to a growing library of datasets describing fish N-glycomes that can eventually establish species-normative baselines for assessing N-glycosylation dynamics associated with pathogen invasion, environmental stress, and fish immunologic responses.
An Ethanolic Extract of Cucurbita pepo L. Seeds Modifies Neuroendocrine Disruption in Chronic Stressed Rats and Adrenal Expression of Inflammatory Markers and HSP70
Authors: Almohaimeed Hailah M. , Hamed Shereen , Seleem Hanan S. , Batawi Ashwaq H. , Mohammedsaleh Zuhair M. , Balgoon Maha Jameal , Ali Soad S. , Al Jaouni Soad , Ayuob Nasra 
Published: November 2021

Background: Pumpkins (Cucurbita pepo L.) were described to have antioxidant, anti-inflammatory, anti-fatigue, and antidepressant-like effect. The adrenal gland is an important stress-responsive organ that maintains homeostasis during stress.Objectives: This study aimed to assess the efficacy of the administration of Cucurbita pepo L. (CP) extract in relieving behavioral, biochemical, and structural changes in the adrenal gland induced by exposure to chronic unpredictable mild stress (CUMS) and to explore the mechanism behind this impact.Materials and Methods: Forty male albino rats were divided into 4 groups (n = 10): control, CUMS, fluoxetine-treated, and CP-treated groups. Behavioral changes, corticosterone level, pro-inflammatory cytokines TNF-α and IL-6, and oxidant/antioxidant profile were assessed in the serum at the end of the experiment. Adrenal glands were processed for histopathological and immunohistochemical assessment. Gene expression of caspase-3 and Ki67 and heat shock protein 70 (HSP70) were assessed in adrenal glands using RT-PCR.Results: The CP extract significantly reduced the corticosterone level (p &lt; 0.001), immobility time (p &lt; 0.001), and inflammatory and oxidative changes associated with CUMS-induced depression compared to the untreated group. The CP extract alleviated CUMS-induced adrenal histopathological changes and significantly reduced apoptosis (p &lt; 0.001) and significantly upregulated antioxidant levels in the serum.Conclusion:Cucurbita pepo L. effectively ameliorated the chronic stress-induced behavioral, biochemical, and adrenal structural changes mostly through its antioxidant and anti-inflammatory effects.
PERLIDUNGAN JUSTICE COLLABORATOR TINDAK PIDANA KORUPSI
Authors: Jupri Jupri 
Published: November 2021

ABSTRACT The guaranted of protection to a Justice Collaborator is stipulated in Article 32 of the United Nations Convention Against Corruption, 2003) as ratified as Law Number 7 Year 2006 stipulates that each State Party is obliged to provide physical and psychological protection against witnesses and experts in the disclosure of criminal acts of corruption. As the development progresses of corruption disclosure in Indonesia, the arrangement of Justice Collaborator is then started to be regulated explicitly in Law Number 31 Year 2014 on Protection of Witness and Victim. Although physical, legal and special protection guarantees against the Justice Collaborator already exist. In fact, in the disclosure of a crime of corruption committed crime, a witness of the perpetrator who cooperates with law enforcement gets bullied until threats are killed. For example in the disclosure of corruption cases involving a number of politicians Political Parties in Indonesia. Keywords: Justice Collaborator, Protection, Corruption
Has the introduction of the possibility to build a single-family house on the basis of notification really improved the development process? The analysis based on the example of the Capital City of Warsaw (Poland)
Authors: Kołacińska Sylwia , Zaborowski Tomasz 
Published: November 2021

On 28 June 2015 an amendment of the Polish Building Code that abolished a requirement to get a building permission to construct or reconstruct a free standing one-family house, which impact area is limited to the plot on that it is planned, came into force. Since then an erection of such houses has been possible on a basis of notification instead. The goal of this amendment was to simplify the development process in the case of one-family houses. This article is a contribution to the verification of this assumption. Therefore data on notifications that were submitted to respective capital city of Warsaw districts’ offices have been analysed. Detailed research has been limited to the districts of Bielany and Białołęka.
MATURASI IKAN LELE MUTIARA Clarias gariepinus BETINA DENGAN ESTRADIOL-17? MELALUI PAKAN
Authors: Febriyanti Risa , Utomo Deny Sapto Chondro , Sarida Munti 
Published: November 2021

Some problems in catfish culture are the spawning circle, female catfish begin to mature gonad at 10 months, and after 1,5 months can spawn again. The purpose of this study was to evaluate the process of accelerating maturation female mutiara catfish with the addition Estradiol-17? by oral treatments. The study was design used 3 treatments : 0 ml/kg feed, 0,4 ml/kg feed, 0,6 ml/kg feed with three individual replications. The result showed that the addition of Estradiol-17? significantly affected on reproductive performance : Gonado Somatic Index (GSI) 102,3% and eggs diameter 16,4% in female mutiara catfish compared with 0 ml/kg feed. Key words : Clarias gariepinus, Eggs Diameter, Estradiol-17ß, Gonadosomatic Index (GSI), Reproductive Performance.
MENINGKATKAN KEMAMPUAN SISWA KELAS XII TKJ 1 TENTANG KONSEP FUNGSI LIMIT MELALUI PEMBELAJARAN DENGAN GOOGLE CLASSROOM DI SMK NEGERI 1 KAYUAGUNG
Authors: Erni Erni 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan belajar siswadalampembelajarandaring dengan model Google Classroom.Penelitian ini merupakan penelitian tindakan kelas dengan subjek penelitiansiswakelas XII TKJ 1 SMK Negeri 1 Kayuagung banyak 32 siswa terdiri 23 laki-laki dan 9 orang perempuan.. Penelitian ini dilaksanakan 2 siklus, masing-masing siklus 2 kali pertemuan. Setiap pertemuan terdiri dari 4 tahap yaitu perencanaan, pelaksanaan, observasi dan refleksi.Pelaksanaan tahap-tahap penelitian sedikit berbeda dari pembelajaran dalamkelas karena pembelajara dilakukan secara terpisah atau siswa berada dirumah masing-masing.Hasil belajar menunjukkan bahwa hasil belajar matematika siswa senantiasa meningkat pada setiap siklusnya. Pada siklus I ketuntasan belajar individual29 orang, secara klasikal 80,60 % dan nilai rata-rata kelas 72,42. Siklus II ketuntasan belajar individual 34 orang, secara klasikal 94,4 % dan rata-rata kelas 79,61. Dengan demikian dapat disimpulkan bahwa penerapan pembelajaran yang menggunakan model Google Classroom tentang konsep Fungsi Limit terbukti efektif dalam meningkatkan hasil belajar siswa pada pelajaran matematika.
PEMBERDAYAAN PEREMPUAN MELALUI PELATIHAN PEMBUATAN KERIPIK SINGKONG ANEKA RASA DI DESA PULAU SEMAMBU OGAN ILIR
Authors: Nurrizalia Mega , Waty Evy Ratna Kartia , Husin Azizah , Nengsih Yanti Karmila , Shomedran Shomedran 
Published: November 2021

Pemberdayaan bukan hanya proses sosial dan politik secara kolektif, tetapi juga merupakan proses sosial dan politik secara individual. Pemberdayaan perempuan bukan hanya suatu proses tetapi juga merupakan hasil. Pelatihan pembuatan keripik singkong aneka rasa merupakan salah satu upaya memberdayakan perempuan khususnya ibu-ibu rumah tangga di desa Pulau Semambu Ogan Ilir. Proses pendampingan keterampilan berwirausaha akan menggunakan metode pembelajaran secara variatif, seperti ceramah, tanya jawab, dan praktik (demonstrasi) dengan payung utama metode pembelajaran partisipatif. Target capaian pemberdayaan perempuan ini dapat dilihat dari beberapa aspek yaitu: (1). jumlah WB yang mengikuti pendampingan berwirausaha yang mengikuti kegiatan, diharapkan minimal 75% dapat menerapkan rangkaian pendampingan; (2) tingkat kompetensi yang dikuasai WB, seluruh warga belajar dapat menguasai seluruh materi pendampingan yang disampaikan; (3) WB mampu berwirausaha , program pendampingan wirausaha ini berorientasi pada pengembangan kemandirian warga belajar dalam menerapkan hasil belajarnya. Karena itu, setelah program ini selesai diharapkan sebagian besar (70%) WB dapat berusaha sendiri baik secara individu maupun berkelompok.
Historia de la arquitectura. Evolución de la arquitectura de Lima desde su espacio interior desde 1821
Authors: Gómez Taipe Wilder 
Published: November 2021

La historia de la arquitectura de Lima se ha escrito en muchos textos. Actualmente se cuentan hasta seis historias. En cada una se ha tratado de ver la arquitectura desde un panorama diferente, pero los une algo en común: son las historias de los edificios y de sus autores, ingenieros, ingenieros-arquitectos o arquitectos. La historia que se presenta a continuación trata sobre la arquitectura de Lima a través de sus espacios interiores y cómo sus autores los han configurado. A partir de la selección de edificios emblemáticos construidos en Lima en los últimos 200 años, se muestra su evolución arquitectónica. Y a partir de una metodología diferente, el presente trabajo busca enlazar esas historias construidas a lo largo del siglo XX con el fin de encontrar, a pesar de sus diferencias o discrepancias, valores comunes. De ese modo, el estudio ha identificado un signo distintivo entre sus formas y configuraciones. Esto sustentaría que esas historias sobre la arquitectura de Lima contienen percepción.
No Detectable Kilonova Counterpart is Expected for O3 Neutron Star–Black Hole Candidates
Authors: Zhu Jin-Ping , Wu Shichao , Yang Yuan-Pei , Zhang Bing , Yu Yun-Wei , Gao He , Cao Zhoujian , Liu Liang-Duan 
Published: November 2021

Abstract
We analyze the tidal disruption probability of potential neutron star–black hole (NSBH) merger gravitational-wave (GW) events, including GW190426_152155, GW190814, GW200105_162426, and GW200115_042309, detected during the third observing run of the LIGO/Virgo Collaboration and the detectability of kilonova emission in connection with these events. The posterior distributions of GW190814 and GW200105_162426 show that they must be plunging events, and hence no kilonova signal is expected from these events. With the stiffest NS equation of state allowed by the constraint of GW170817 taken into account, the probability that GW190426_152155 and GW200115_042309 can make tidal disruption is ∼24% and ∼3%, respectively. However, the predicted kilonova brightness is too faint to be detected for present follow-up search campaigns, which explains the lack of electromagnetic (EM) counterpart detection after triggers of these GW events. Based on the best-constrained population synthesis simulation results, we find that disrupted events account for only ≲20% of cosmological NSBH mergers, since most of the primary BHs could have low spins. The associated kilonovae for those disrupted events will still be difficult for LSST to discover after GW triggers in the future because of their low brightness and larger distances. For future GW-triggered multimessenger observations, potential short-duration gamma-ray bursts and afterglows are more probable EM counterparts of NSBH GW events.
Gamma Rays from Fast Black-hole Winds
Authors: Ajello M. , Baldini L. , Ballet J. , Barbiellini G. , Bastieri D. , Bellazzini R. , Berretta A. , Bissaldi E. , Blandford R. D. , Bloom E. D. , Bonino R. , Bruel P. , Buson S. , Cameron R. A. , Caprioli D. , Caputo R. , Cavazzuti E. , Chartas G. , Chen S. , Cheung C. C. , Chiaro G. , Costantin D. , Cutini S. , D’Ammando F. , de la Torre Luque P. , de Palma F. , Desai A. , Diesing R. , Di Lalla N. , Dirirsa F. , Di Venere L. , Domínguez A. , Fegan S. J. , Franckowiak A. , Fukazawa Y. , Funk S. , Fusco P. , Gargano F. , Gasparrini D. , Giglietto N. , Giordano F. , Giroletti M. , Green D. , Grenier I. A. , Guiriec S. , Hartmann D. , Horan D. , Jóhannesson G. , Karwin C. , Kerr M. , Kovačević M. , Kuss M. , Larsson S. , Latronico L. , Lemoine-Goumard M. , Li J. , Liodakis I. , Longo F. , Loparco F. , Lovellette M. N. , Lubrano P. , Maldera S. , Manfreda A. , Marchesi S. , Marcotulli L. , Martí-Devesa G. , Mazziotta M. N. , Mereu I. , Michelson P. F. , Mizuno T. , Monzani M. E. , Morselli A. , Moskalenko I. V. , Negro M. , Omodei N. , Orienti M. , Orlando E. , Paliya V. , Paneque D. , Pei Z. , Persic M. , Pesce-Rollins M. , Porter T. A. , Principe G. , Racusin J. L. , Rainò S. , Rando R. , Rani B. , Razzano M. , Reimer A. , Reimer O. , Saz Parkinson P. M. , Serini D. , Sgrò C. , Siskind E. J. , Spandre G. , Spinelli P. , Suson D. J. , Tak D. , Torres D. F. , Troja E. , Wood K. , Zaharijas G. , Zrake J. 
Published: November 2021

Abstract
Massive black holes at the centers of galaxies can launch powerful wide-angle winds that, if sustained over time, can unbind the gas from the stellar bulges of galaxies. These winds may be responsible for the observed scaling relation between the masses of the central black holes and the velocity dispersion of stars in galactic bulges. Propagating through the galaxy, the wind should interact with the interstellar medium creating a strong shock, similar to those observed in supernovae explosions, which is able to accelerate charged particles to high energies. In this work we use data from the Fermi Large Area Telescope to search for the γ-ray emission from galaxies with an ultrafast outflow (UFO): a fast (v ∼ 0.1 c), highly ionized outflow, detected in absorption at hard X-rays in several nearby active galactic nuclei (AGN). Adopting a sensitive stacking analysis we are able to detect the average γ-ray emission from these galaxies and exclude that it is due to processes other than UFOs. Moreover, our analysis shows that the γ-ray luminosity scales with the AGN bolometric luminosity and that these outflows transfer ∼0.04% of their mechanical power to γ-rays. Interpreting the observed γ-ray emission as produced by cosmic rays (CRs) accelerated at the shock front, we find that the γ-ray emission may attest to the onset of the wind–host interaction and that these outflows can energize charged particles up to the transition region between galactic and extragalactic CRs.