bluuebunny/crossref_metadata_2025_split huggingface dataset:
Człowiek w obliczu epidemii - relacja Tukidydesa i Prokopiusza z Cezarei
Authors: Siwicka Małgorzata 
Published: November 2021

Dwie dramatyczne sytuacje społeczne, związane z wybuchem choroby o charakterze epidemicznym, opisane przez Tukidydesa oraz Prokopiusza z Cezarei oddziela niemal tysiąc lat rozpiętości czasowej. Obydwaj ci autorzy byli naocznymi świadkami przedstawianych wydarzeń, Tukidydes ponadto sam zaraził się, lecz przeżył tajemniczą chorobę, która spadła na mieszkańców Attyki w pierwszych latach wojny peloponeskiej. Prokopiusz, wzorując się na opisie Tukidydesa, przedstawia najprawdopodobniej pierwszy przypadek dżumy na terenie Europy, która wywarła znacznie większy wpływ na losy mieszkańców Konstantynopola a także całego imperium bizantyńskiego nie tylko w wieku VI po Chr. lecz i w następnych stuleciach. Opis Tukidydesa, zwięzły, z użyciem fachowej terminologii medycznej, dostarcza nie tylko dokładnego obrazu samych objawów tej choroby, lecz także maluje przed oczyma czytelnika różnorodność ludzkich postaw i zachowań w sytuacji skrajnego zagrożenia, w obliczu ciągłego niebezpieczeństwa utraty własnego życia i straty osób najbliższych, kiedy to człowiek nie jest wstanie wywierać jakiegokolwiek wpływu na dotykające go wydarzenia. Tukidydes podkreśla zgubne skutki zarazy, jakie powoduje ona w sferze etycznej i społecznej człowieka. W obliczu ogromu nieszczęścia pojawia się skłonność do odrzucenia zasad religijnych i norm prawnych, co prowadzi do pogoni za szybkim zyskiem i przyjemnością, jak też do zerwania więzi społecznych, pozostawiania bliskich na pastwę choroby. Tukidydes, pozostając pesymistą w ocenie natury ludzkiej, która, jego zdaniem właśnie w takich skrajnych sytuacjach ujawnia swe najciemniejsze strony, nie zapomina jednak o osobach, które zachowały postawę szlachetną, pełną współczucia dla cierpiących. Podkreśla ogromne poświęcenie lekarzy, oraz tych, którzy śpieszyli z pomocą nie tylko rodzinie, ale i opuszczonym w nieszczęściu przyjaciołom, często płacąc za to własnym życiem. Prokopiusz naśladując w strukturze, a nawet w niektórych sformułowaniach swego opisu Tukidydesa, nie rezygnuje bynajmniej z rzetelnego przedstawienia realiów sytuacji, w jakiej się znalazł. Ponieważ jego relacja dotyczy innej choroby, inne są też objawy, które skrupulatnie relacjonuje. Poświęca więcej miejsca działaniom, jakie podjęto, aby opanować chaos panujący w mieście i zorganizować uprzątanie zwłok i pochówki zmarłych, a także wspomina o skutkach, jakie epidemia wywarła w sferze gospodarczej cesarstwa. Podobnie jak Tukidydes, skupia swoją uwagę na zachowaniu człowieka w sytuacji skrajnego zagrożenia i prezentuje cały wachlarz ludzkich postaw: od ludzi pełnych poświęcenia, ryzykujących własnym życiem, aby ratować innych do osób egoistycznie skupionych na pogoni za przyjemnością i użyciem, łamiących prawo i wszelkie zasady religijne. W jego komentarzach pojawia się niekiedy więcej goryczy, a czasami wręcz złośliwości, gdy mówi, iż choroba zabrała najszlachetniejsze, najbardziej wartościowe jednostki, a pozostawiła przy życiu wyjątkowo podłych i nikczemnych
The 'Wordsworth-Spinoza Link' and Ethics: Motivating the Wordsworthian Moral
Authors: Ginther Logan 
Published: November 2021

Marjorie Levinson has established a link between Spinoza's philosophy and Wordsworth's poetry, focussing specifically on the two authors' shared metaphysics. In this paper I will follow the chain of Levinson's link and show that Spinoza and Wordsworth share an ethics, too. Spinoza's is an ethics of perspective; his primary prescription is to hold a perspective which acknowledges the metaphysical truth of the interconnectedness of all things for the sake of one's mental health. After grounding Wordsworth's well-known prescriptions of communion with nature in a metaphysics of monistic Nature (as Spinoza suggests), we will be in possession of vocabulary with which to describe a much deeper version of the Wordsworthian moral than has hitherto been familiar. Importantly, though we arrive at our description of the Wordsworthian moral by following Spinoza, it remains markedly Wordsworthian and is a novel particularization of Spinoza's general ethical suggestion.
THE DEMOGRAPHIC PROFILE OF WOMEN WITH GESTATIONAL DIABETES MELLITUS
Authors: Inaniya Priyanka , Meena B S , Meena Mohan Lal , Sharma Aparna , Rathore Shalini 
Published: November 2021

Background: The present study aimed to study the demographic profile women with gestational diabetes mellitus
Methods: This hospital based cross-sectional study Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur.
Results: Mean age of patients was 27.68 ± 4.4 Yrs. Most of the study subjects in GDM group (54.7%) were Hindu. Study subjects in GDM group were almost equally from rural (50.7%).Most of the study subjects in both GDM group (88%) were housewives. Habit of smoking was found in only 6.7% females in GDM group. Habit of alcohol was found in 4% females in GDM group. Family history of diabetes was seen more in females with GDM (17.3%).
Conclusion: This study concluded that the socio demographic factors influence the occurrence of GDM.
Keywords: GDM, Age, Gravida
A CONVENIÊNCIA, A OPORTUNIDADE E A SUSTENTABILIDADE COMO CRITÉRIOS JUDICIAIS NO REGISTRO DE TÍTULOS NO REGISTRO DE IMÓVEIS
Authors: Marchionatti Carlos Cini , Cansi Francine , Cruz Paulo Márcio 
Published: November 2021

A Conveniência e a Oportunidade são critérios legais e judiciais de decidir em Jurisdição Voluntária. Quando o Oficial do Registro de Imóveis deixa de registrar título apresentado para registro no Registro de Imóveis por causa das exigências legais ou da Legalidade Estrita, esta objeção ao registro pode ser submetida ao Juiz de Direito competente, conhecimento e julgamento que ocorrem em Jurisdição Voluntária, onde incidem a Conveniência e a Oportunidade. A Sustentabilidade também pode aparecer como razão judicial de julgar, concomitante à Conveniência e à Oportunidade.
Palavras-Chave: Sustentabilidade. Conveniência. Oportunidade. Jurisdição voluntária. Registro de Imóveis.

Abstract: The Convenience anda Opportunity are legal and judicial criteria for deciding on Voluntary Jurisdiction. When the Notary Officier of Property Registration refuses to book the propriety’s title due to the legal requirements or Strict Legality, this objection to registraty may be submitted to the competente Judge of Law, acknowledging and judging it in Voluntary, where the Convenience and Opportunity are applied. Sustainability miggt also be presente as a judicial reason of deciding concurrent with Convenient and Opportunity.
Keywords: Sustentability. Convenience. Opportunity. Voluntary Jurisdiction. Property Registration.
L’importanza del vaccino anti Covid-19 nei pazienti affetti da malattia del rene policistico autosomico dominante dell’adulto (ADPKD)
Authors: Sciarrone Alibrandi Maria Teresa , Joli Giancarlo , Rivera Rodolfo F. , Brioni Elena , Bucci Romina , Vespa Marta 
Published: November 2021

The SARS-CoV-2 (Covid-19) infection affected about 106 million people worldwide and the total amount of casualties now sits at a staggering 2 millions.
Chronic Kidney Disease (CKD) emerged as the first risk factor in worst patients, not considering old age. Kidney disease and acute kidney injury have been correlated with a higher chance of death. This combination of CKD and higher Covid-19 related mortality requires immediate response from a prevention point of view at first and then from a therapeutic one.
There is not a clear relation between Covid-19 and ADPKD. What can be inferred is the following: Covid uses the ACE2 receptors on cell membranes to “lock on” its target. It is well-established in fact that the RAAS is more active in ADPKD patients and it may represent an additional risk factor for these patients.
At the moment three Covid-19 vaccines have been approved, and two of them have been already administered, such as Pfizer BioNTech and Moderna, sharing the same mechanism. AstraZeneca released a third option. All of them are completely safe and reliable, each one with its own feature.
Therefore, considering how delicate ADPKD patients are, vaccination is strongly recommended.
Pemulihan Identitas Naratif Korban Kekerasan Seksual:
Authors: Layantara Jessica Novia , Tobing David 
Published: November 2021

Sebagai peristiwa traumatik, kekerasan seksual melumpuhkan identitas korban sehingga menjadikan korban kehilangan keberdayaan sebagai manusia. Namun, identitas korban-korban kekerasan seksual itu dapat dipulihkan. Pertanyaan yang ingin dijawab dalam artikel ini adalah apa yang memungkinkan, secara filosofis dan teologis, pemulihan atau perubahan identitas korban (victim) menjadi identitas penyintas tertebus (redeemed survivor). Artikel ini akan berupaya menjawab pertanyaan tersebut dari sudut pandang filsafat Paul Ricoeur mengenai identitas naratif sebagai kerangka (form) dan teologi Miroslav Volf mengenai ingatan kudus (sacred memory) dalam sejarah keselamatan sebagai isi (matter) dari identitas penyintas tertebus. Tesis dalam artikel ini adalah pemulihan atau perubahan identitas korban menjadi penyintas tertebus dimungkinkan melalui pemulihan identitas naratif korban yang berisi memori suci (sacred memory) dalam paradigma naratif sejarah keselamatan Kristen.
A Label-Based Polymer Nanoparticles Biosensor Combined with Loop-Mediated Isothermal Amplification for Rapid, Sensitive, and Highly Specific Identification of Brucella abortus
Authors: Yang Xinggui , Wang Yue , Liu Ying , Huang Junfei , Tan Qinqin , Ying Xia , Hu Yong , Li Shijun 
Published: November 2021

Brucella abortus (B. abortus), an important zoonotic pathogen in Brucella spp., is the major causative agent of abortion in cattle (namely, bovine brucellosis). Currently, although the isolation and identification of the Brucella abortus were commonly accepted as the gold standard method, it cannot meet the requirements for early diagnostic strategies. Conventional PCR techniques and immunological tests can realize rapid detection of B. abortus, but the demands for PCR thermal cyclers and/or specific antibodies hinder their application in basic laboratories. Thus, rapid, sensitive, and specific diagnostic strategies are essential to prevent and control the spread of the bovine brucellosis. In this work, a novel detection method for the rapid identification of B. abortus, which uses loop-mediated isothermal amplification (LAMP) combined with a label-based polymer nanoparticles lateral flow immunoassay biosensor (LFIA), was established. One set of specific B. abortus-LAMP primers targeting the BruAb2_0168 gene was designed by the online LAMP primer design tool. The B. abortus-LAMP-LFIA assay was optimized and evaluated using various pathogens and whole blood samples. The optimal amplification temperature and time for B. abortus-LAMP-LFIA were determined to be 65°C and 50 min, respectively. The B. abortus-LAMP-LFIA method limit of detection (LoD) was 100 fg per reaction for pure genomic DNA of B. abortus. Meanwhile, the detection specificity was 100%, and there was no cross-reactivity for other Brucella members and non-Brucella strains. Furthermore, the entire procedure, including the DNA preparation for whole blood samples (30 min), isothermal incubation (50 min), and LFIA detection (2–5 min), can be completed in approximately 85 min. Thus, the B. abortus-LAMP-LFIA assay developed was a simple, rapid, sensitive, and reliable detection technique, which can be used as a screening and/or diagnostic tool for B. abortus in the field and basic laboratories.
The Association Between Time-Varying Wall Shear Stress and the Development of Plaque Ulcerations in Carotid Arteries From the Plaque at Risk Study
Authors: Dilba Kristine , van Dam-Nolen Dianne H. K. , Korteland Suze-Anne , van der Kolk Anja G. , Kassem Mohamed , Bos Daniel , Koudstaal Peter J. , Nederkoorn Paul J. , Hendrikse Jeroen , Kooi M. Eline , Gijsen Frank J. H. , van der Steen Anton F. W. , van der Lugt Aad , Wentzel Jolanda J. 
Published: November 2021

Background and Purpose: Shear stress (WSS) is involved in the pathophysiology of atherosclerotic disease and might affect plaque ulceration. In this case-control study, we compared carotid plaques that developed a new ulcer during follow-up and plaques that remained silent for their exposure to time-dependent oscillatory shear stress parameters at baseline.Materials and Methods: Eighteen patients who underwent CTA and MRI of their carotid arteries at baseline and 2 years follow-up were included. These 18 patients consisted of six patients who demonstrated a new ulcer and 12 control patients selected from a larger cohort with similar MRI-based plaque characteristics as the ulcer group. (Oscillatory) WSS parameters [time average WSS, oscillatory shear index (OSI), and relative residence time (RRT)] were calculated using computational fluid dynamics applying the MRI-based geometry of the carotid arteries and compared among plaques (wall thickness&gt;2 mm) with and without ulceration (Mann–Whitney U test) and ulcer-site vs. non-ulcer-site within the plaque (Wilcoxon signed rank test). More detailed analysis on ulcer cases was performed and the predictive value of oscillatory WSS parameters was calculated using linear and logistic mixed-effect regression models.Results: The ulcer group demonstrated no difference in maximum WSS [9.9 (6.6–18.5) vs. 13.6 (9.7–17.7) Pa, p = 0.349], a lower maximum OSI [0.04 (0.01–0.10) vs. 0.12 (0.06–0.20) p = 0.019] and lower maximum RRT [1.25 (0.78–2.03) Pa−1 vs. 2.93 (2.03–5.28) Pa−1, p = 0.011] compared to controls. The location of the ulcer (ulcer-site) within the plaque was not always at the maximal WSS, but demonstrated higher average WSS, lower average RRT and OSI at the ulcer-site compared to the non-ulcer-sites. High WSS (WSS&gt;4.3 Pa) and low RRT (RRT &lt; 0.25 Pa) were associated with ulceration with an odds ratio of 3.6 [CI 2.1–6.3] and 2.6 [CI 1.54–4.44] respectively, which remained significant after adjustment for wall thickness.Conclusion: In this explorative study, ulcers were not exclusively located at plaque regions exposed to the highest WSS, OSI, or RRT, but high WSS and low RRT regions had a significantly higher odds to present ulceration within the plaque even after adjustment for wall thickness.
Pre-operative Cerebral Small Vessel Disease on MR Imaging Is Associated With Cerebral Hyperperfusion After Carotid Endarterectomy
Authors: Fan Xiaoyuan , Lai Zhichao , Lin Tianye , You Hui , Wei Juan , Li Mingli , Liu Changwei , Feng Feng 
Published: November 2021

Objectives: To determine whether pre-operative cerebral small vessel disease is associated with cerebral hyperperfusion (CH) after carotid endarterectomy (CEA).Methods: Seventy-seven patients (mean age of 66 years and 58% male) undergoing CEA for carotid stenosis were investigated using brain MRI before and after surgery. CH was defined as an increase in cerebral blood flow &gt; 100% compared with pre-operative values on arterial spin labeling MR images. The grade or the number of four cerebral small vessel disease markers (white matter hyperintensities, lacunes, perivascular spaces, and cerebral microbleeds) were evaluated based on pre-operative MRI. Cerebral small vessel disease markers were correlated with CH by using multivariate logistic regression analysis. The cutoff values of cerebral small vessel disease markers for predicting CH were assessed by receiver-operating characteristic curve analysis.Results: CH after CEA was observed in 16 patients (20.78%). Logistic regression analysis revealed that white matter hyperintensities (OR 3.09, 95% CI 1.72–5.54; p &lt; 0.001) and lacunes (OR 1.37, 95% CI 1.06–1.76; p = 0.014) were independently associated with post-operative CH. Receiver-operating characteristic curve analysis showed that Fazekas score of white matter hyperintensities ≥3 points [area under the curve (AUC) = 0.84, sensitivity = 81.3%, specificity = 73.8%, positive predictive value (PPV) = 44.8% and negative predictive value (NPV) = 93.8%] and number of lacunes ≥ 2 (AUC = 0.73, sensitivity = 68.8%, specificity = 78.7%, PPV = 45.8% and NPV = 90.6%) were the optimal cutoff values for predicting CH.Conclusion: In patients with carotid stenosis, white matter hyperintensities and lacunes adversely affect CH after CEA. Based on the NPVs, pre-operative MR imaging can help identify patients who are not at risk of CH.
The Predictive Value of Myoglobin for COVID-19-Related Adverse Outcomes: A Systematic Review and Meta-Analysis
Authors: Ma Chaoqun , Tu Dingyuan , Gu Jiawei , Xu Qiang , Hou Pan , Wu Hong , Guo Zhifu , Bai Yuan , Zhao Xianxian , Li Pan 
Published: November 2021

Objective: Cardiac injury is detected in numerous patients with coronavirus disease 2019 (COVID-19) and has been demonstrated to be closely related to poor outcomes. However, an optimal cardiac biomarker for predicting COVID-19 prognosis has not been identified.Methods: The PubMed, Web of Science, and Embase databases were searched for published articles between December 1, 2019 and September 8, 2021. Eligible studies that examined the anomalies of different cardiac biomarkers in patients with COVID-19 were included. The prevalence and odds ratios (ORs) were extracted. Summary estimates and the corresponding 95% confidence intervals (95% CIs) were obtained through meta-analyses.Results: A total of 63 studies, with 64,319 patients with COVID-19, were enrolled in this meta-analysis. The prevalence of elevated cardiac troponin I (cTnI) and myoglobin (Mb) in the general population with COVID-19 was 22.9 (19–27%) and 13.5% (10.6–16.4%), respectively. However, the presence of elevated Mb was more common than elevated cTnI in patients with severe COVID-19 [37.7 (23.3–52.1%) vs.30.7% (24.7–37.1%)]. Moreover, compared with cTnI, the elevation of Mb also demonstrated tendency of higher correlation with case-severity rate (Mb, r = 13.9 vs. cTnI, r = 3.93) and case-fatality rate (Mb, r = 15.42 vs. cTnI, r = 3.04). Notably, elevated Mb level was also associated with higher odds of severe illness [Mb, OR = 13.75 (10.2–18.54) vs. cTnI, OR = 7.06 (3.94–12.65)] and mortality [Mb, OR = 13.49 (9.3–19.58) vs. cTnI, OR = 7.75 (4.4–13.66)] than cTnI.Conclusions: Patients with COVID-19 and elevated Mb levels are at significantly higher risk of severe disease and mortality. Elevation of Mb may serve as a marker for predicting COVID-19-related adverse outcomes.Prospero Registration Number:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020175133, CRD42020175133.
Cryoballoon Ablation Strategy in Persistent Atrial Fibrillation
Authors: Straube Florian , Pongratz Janis , Kosmalla Alexander , Brueck Benedikt , Riess Lukas , Hartl Stefan , Tesche Christian , Ebersberger Ullrich , Wankerl Michael , Dorwarth Uwe , Hoffmann Ellen 
Published: November 2021

Background: Cryoballoon ablation is established for pulmonary vein isolation (PVI) in paroxysmal atrial fibrillation (AF). The objective was to evaluate CBA strategy in consecutive patients with persistent AF in the initial AF ablation procedure.Material and Methods: Prospectively, patients with symptomatic persistent AF scheduled for AF ablation all underwent cryoballoon PVI. Technical enhancements, laboratory management, safety, single-procedure outcome, predictors of recurrence, and durability of PVI were evaluated.Results: From 2007 to 2020, a total of 1,140 patients with persistent AF, median age 68 years, underwent cryoballoon ablation (CBA). Median left atrial (LA) diameter was 45 mm (interquantile range, IQR, 8), and Congestive heart failure, Hypertension, Age ≥75 years (doubled), Diabetes mellitus, prior Stroke or TIA or thromboembolism (doubled), Vascular disease, Age 65 to 74 years, Sex category (CHA2DS2-VASc) score was 3. Acute isolation was achieved in 99.6% of the pulmonary veins by CBA. Median LA time and median dose area product decreased significantly over time (p &lt; 0.001). Major complications occurred in 17 (1.5%) patients including 2 (0.2%) stroke/transitory ischemic attack (TIA), 1 (0.1%) tamponade, relevant groin complications, 1 (0.1%) significant ASD, and 4 (0.4%) persistent phrenic nerve palsy (PNP). Transient PNP occurred in 66 (5.5%) patients. No atrio-esophageal fistula was documented. Five deaths (0.4%), unrelated to the procedure, occurred very late during follow-up. After initial CBA, arrhythmia recurrences occurred in 46.6% of the patients. Freedom from atrial arrhythmias at 1-, and 2-year was 81.8 and 61.7%, respectively. Independent predictors of recurrence were LA diameter, female sex, and use of the first cryoballoon generation. Repeat ablations due to recurrences were performed in 268 (23.5%) of the 1,140 patients. No pulmonary vein (PV) reconduction was found in 49.6% of the patients and 73.5% of PVs. This rate increased to 66.4% of the patients and 88% of PVs if an advanced cryoballoon was used in the first AF ablation procedure.Conclusion: Cryoballoon ablation for symptomatic persistent AF is a reasonable strategy in the initial AF ablation procedure.
Integrated Care of Atrial Fibrillation Using the ABC (Atrial fibrillation Better Care) Pathway Improves Clinical Outcomes in Chinese Population: An Analysis From the Chinese Atrial Fibrillation Registry
Authors: Wang Yu-Feng , Jiang Chao , He Liu , Du Xin , Sang Cai-Hua , Long De-Yong , Tang Ri-Bo , Dong Jian-Zeng , Lip Gregory Y. H. , Ma Chang-Sheng 
Published: November 2021

Background: “Atrial fibrillation Better Care” (ABC) pathway has been proposed to improve the management of patients suffered from atrial fibrillation (AF). This integrated or holistic management approach comprise of three aspects, including “A” Avoid stroke or Anticoagulation; “B” Better symptom control with rate or rhythm control strategies; “C” Cardiovascular risk factor and Concomitant diseases management. We aimed to confirm the beneficial evidence of ABC pathway compliance in a Chinese AF cohort.Method and Results: From the Chinese Atrial Fibrillation registry (CAFR) dataset, a total of 19,187 non-valvular AF patients were enrolled, of which 4.365 (22.8%) were ABC pathway compliant (ABC compliance group). During a median follow-up of 4.1 ± 1.8 years, The incident rate of all-cause death in ABC compliance group and non-ABC compliance group is 2.7 and 1.1 per 100 person-year (p &lt; 0.001), the incident rate of ischemic stroke is 1.3 and 0.8% per 100 person-year (p &lt; 0.001), the incident rate of composite outcome, which consist of all-cause death, ischemic stroke and intracranial hemorrhage, is 3.8 and 1.9 per 100 person-year (p &lt; 0.001). On Cox multivariable analysis, ABC pathway shows an independently association with reduction of all-cause death [hazard ratio (HR) = 0.82; 95% confidence interval (CI) = 0.70–0.95] and the composite outcome (HR 0.86, 95% CI 0.76–0.96). The increasingly components of ABC integrated care compliance is associated with lower risk of all-cause death and composite events.Conclusion: In a large cohort of Chinese AF patients, ABC pathway compliance shows an independently association with reduction of all-cause death and composite outcome of all-cause death, ischemic stroke and intracranial hemorrhage. Better compliance of ABC integrated care contributes to lower HR for adverse events.