bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quadratic optimal control and feedback stabilization of bilinear systems
Authors: Yahyaoui Soufiane , Ouzahra Mohamed 
Published: January 2021

AbstractIn this work, we investigate the quadratic bilinear optimal control. We first review the case of finite‐time interval, and then focus on the case of infinite‐time horizon. The main difficulty in solving a quadratic optimal control for bilinear systems is the non‐convexity of the cost function, which due to the fact that the dependence of the state with respect to the control is highly nonlinear. Then we provide a class of bilinear systems, including the commutative case, for which the optimal control can be expressed as a time‐varying feedback control. We further show that under a controllability inequality, the obtained optimal control guarantees the strong stability of the resulting system. The techniques rely on linear semigroup theory and conditions of optimality. Applications to transport and heat equations are also presented.
Late gestation predictors of a postnatal biventricular circulation after fetal aortic valvuloplasty
Authors: Beattie Meaghan J. , Friedman Kevin G. , Sleeper Lynn A. , Lu Minmin , Drogosz Monika , Callahan Ryan , Marshall Audrey C. , Prosnitz Aaron R. , Lafranchi Terra , Benson Carol B. , Wilkins‐Haug Louise E. , Tworetzky Wayne 
Published: January 2021

AbstractObjectivesFetal aortic valvuloplasty (FAV) for severe aortic stenosis (AS) has shown promise in averting progression to hypoplastic left heart syndrome. After FAV, predicting which fetuses will achieve a biventricular (BiV) circulation after birth remains challenging. Identifying predictors of postnatal circulation on late gestation echocardiography will improve parental counseling.MethodsLiveborn patients who underwent FAV and had late gestation echocardiography available were included (2000–2017, n = 96). Multivariable logistic regression and classification and regression tree analysis were utilized to identify independent predictors of BiV circulation.ResultsAmong 96 fetuses, 50 (52.1%) had BiV circulation at the time of neonatal discharge. In multivariable analysis, independent predictors of biventricular circulation included left ventricular (LV) long axis z‐score (OR 3.2, 95% CI 1.8–5.7, p < 0.001), LV ejection fraction (OR 1.3, 95% CI 1.0–1.8, p = 0.023), anterograde aortic arch flow (OR 5.0, 95% CI 1.2–20.4, p = 0.024), and bidirectional or right‐to‐left foramen ovale flow (OR 4.6, 95% CI 1.4–15.8, p = 0.015).ConclusionSeveral anatomic and physiologic parameters in late gestation were found to be independent predictors of BiV circulation after FAV. Identifying these predictors adds to our understanding of LV growth and hemodynamics after FAV and may improve parental counseling.
Three‐dimensional multi‐ribbon interconnection for back‐contact solar cells
Authors: Van Dyck Rik , Borgers Tom , Govaerts Jonathan , Poortmans Jef , van Vuure Aart Willem 
Published: January 2021

AbstractBack‐contact solar cells are an interesting technology with advantages over traditional two‐sided cells. A lack of standardized and low‐cost interconnection methods inhibits their market penetration. In an attempt to overcome this obstacle, this work introduces an interconnection technology, based on a fabric of encapsulant with incorporated metal ribbons. The encapsulant is tailored for this application by adding glass fibres to a thermoplastic polyolefin. For this tailored encapsulant, characterization experiments were conducted and results on viscosity and coefficient of thermal expansion are shown. Initial reliability testing on sample‐size modules with high‐efficiency interdigitated back‐contact (IBC) cells shows promising results, passing up to four times the IEC 61215 standard for thermal cycling.
Development of mPing‐based activation tags for crop insertional mutagenesis
Authors: Johnson Alexander , Mcassey Edward , Diaz Stephanie , Reagin Jacob , Redd Priscilla S. , Parrilla Daymond R. , Nguyen Hanh , Stec Adrian , McDaniel Lauren A. L. , Clemente Thomas E. , Stupar Robert M. , Parrott Wayne A. , Hancock C. Nathan 
Published: January 2021

AbstractModern plant breeding increasingly relies on genomic information to guide crop improvement. Although some genes are characterized, additional tools are needed to effectively identify and characterize genes associated with crop traits. To address this need, the mPing element from rice was modified to serve as an activation tag to induce expression of nearby genes. Embedding promoter sequences in mPing resulted in a decrease in overall transposition rate; however, this effect was negated by using a hyperactive version of mPing called mmPing20. Transgenic soybean events carrying mPing‐based activation tags and the appropriate transposase expression cassettes showed evidence of transposition. Expression analysis of a line that contained a heritable insertion of the mmPing20F activation tag indicated that the activation tag induced overexpression of the nearby soybean genes. This represents a significant advance in gene discovery technology as activation tags have the potential to induce more phenotypes than the original mPing element, improving the overall effectiveness of the mutagenesis system.
Glycerolipid profile differences between perennial and annual stem zones in the perennial model plant Arabis alpina
Authors: Sergeeva Anna , Mettler‐Altmann Tabea , Liu Hongjiu , Mai Hans‐Jörg , Bauer Petra 
Published: January 2021

AbstractThe perennial life style is a successful ecological strategy, and Arabis alpina is a recently developed model Brassicaceae species for studying it. One aspect, poorly investigated until today, concerns the differing patterns of allocation, storage, and metabolism of nutrients between perennials and annuals and the yet unknown signals that regulate this process. A. alpina has a complex lateral stem architecture with a proximal vegetative perennial (PZ) and a distal annual flowering zone (AZ) inside the same stems. Lipid bodies (LBs) with triacylglycerols (TAGs) accumulate in the PZ. To identify potential processes of lipid metabolism linked with the perennial lifestyle, we analyzed lipid species in the PZ versus AZ. Glycerolipid fractions, including neutral lipids with mainly TAGs, phospholipids, and glycolipids, were present at higher levels in the PZ as compared to AZ or roots. Concomitantly, contents of specific long‐chain and very long‐chain fatty acids increased during formation of the PZ. Corresponding gene expression data, gene ontology term enrichment, and correlation analysis with lipid species pinpoint glycerolipid‐related genes to be active during the development of the PZ. Possibilities that lipid metabolism genes may be targets of regulatory mechanisms specifying PZ differentiation in A. alpina are discussed.
Glycolytic inhibitor induces metabolic crisis in solid cancer cells to enhance cold plasma‐induced cell death
Authors: Kaushik Nagendra K. , Kaushik Neha , Bhartiya Pradeep , Nguyen Linh N. , Choi Eun H. 
Published: January 2021

AbstractTargeting metabolic regulation in cancer cells through metabolic reprogramming is of interest among researchers with regard to preferential cancer cell killing. Evidence indicates that the combination of metabolic modifiers with anticancer therapies attains the expected therapeutic efficiency, suggesting a potential for selective cancer cell death. Here, we have shown that the use of 2‐deoxy‐d‐glucose, a metabolic modifier, enhances the efficiency of air gas plasma treatment at lower doses, resulting in cellular energy loss, which can be attributed to metabolic energy crisis in mitochondria. Interestingly, this novel approach is selective for solid cancer cells over normal cells, thus displaying great potential for increasing nonthermal plasma activity.
Permeation‐resistant and flexible plasma‐polymerised films on 2‐hydroxyethyl methacrylate hydrogels
Authors: Rout Bishakh , Girard‐Lauriault Pierre‐Luc 
Published: January 2021

AbstractThis study focuses on the deposition of plasma polymer films (PPFs) on hydrogels that could act as permeation barriers for aqueous species. The deposited PPFs on hydrogels were studied in terms of their ability to resist the permeation of an aqueous dye molecule after 24‐h exposure to an aqueous solution and mechanical stress. Permeation of the dye toluidine blue O through the hydrogels after plasma polymerisation was at least 75% less than that through an untreated hydrogel. The X‐ray photoelectron spectroscopy analysis showed introduction of O‐ and N‐rich chemical functionalities in the surface chemical composition of the hydrogel after plasma polymerisation. Scanning electron microscope imaging pointed out that milder plasma conditions result in uniform films that do not degrade upon exposure to water or mechanical stress.
Imaging expression of prostate‐specific membrane antigen and response to PSMA‐targeted β‐emitting radionuclide therapies in metastatic castration‐resistant prostate cancer
Authors: Vlachostergios Panagiotis J. , Niaz Muhammad Junaid , Skafida Myrto , Mosallaie Seyed Ali , Thomas Charlene , Christos Paul J. , Osborne Joseph R. , Molina Ana M. , Nanus David M. , Bander Neil Harrison , Tagawa Scott T. 
Published: January 2021

AbstractBackgroundProstate‐specific membrane antigen (PSMA)‐targeted radionuclide therapy (TRT) has demonstrated efficacy and tolerability with a dose–response effect in phase I/II trials in men with metastatic castration‐resistant prostate cancer (mCRPC). The need for positive PSMA imaging before PSMA‐TRT to select patients is largely practiced, but its utility is not proven. Given target heterogeneity, developing a biomarker to identify the optimal patient population remains an unmet need. The aim of this study was to assess PSMA uptake by imaging and response to PSMA‐TRT.MethodsWe performed an analysis of men with mCRPC enrolled in sequential prospective phase I/II trials of PSMA‐TRT. Each patient had baseline PSMA imaging by planar 111In and/or 177Lu SPECT (N = 171) or 68Ga‐PSMA‐11 PET/CT (N = 44), but the results were not used to include/exclude treatment. Semiquantitative imaging scores (IS) on a 0‐4 scale were assigned based on PSMA uptake in tumors compared to liver uptake. We compared the ≥50% PSA decline response proportions between low (0–1) and high (2–4) PSMA IS using the χ2‐test. We used multivariable logistic regression analysis to understand the relationship between independent and dependent variables, including IS, radionuclide activity (dose) administered, CALGB (Halabi) prognostic risk score, prior taxane use.Results215 men with progressive mCRPC received PSMA‐TRT as follows: 177Lu‐J591 (n = 137), 177Lu‐PSMA‐617 (n = 44), 90Y‐J591 (n = 28), 177Lu‐J591 + 177Lu‐PSMA‐617 (n = 6). High PSMA expression (IS 2–4) was found in 160 (74.4%) patients and was significantly associated with more frequent ≥ 50% PSA reduction (26.2 vs. 7.3%, p = .006). On multivariate logistic regression analysis, higher IS was associated with a ≥50% decrease in PSA, even after accounting for CALGB (Halabi) prognostic score, the dose administered, and previous taxane use (OR, 4.72; 95% CI, 1.71−16.85; p = .006). Patients with low PSMA expression (N = 55, 24.7%) were less likely to respond. Thirteen of 26 (50%) with no PSMA uptake (IS = 0) had post‐PSMA‐TRT PSA decline with 2 (7.7%) having ≥ 50% PSA declines.ConclusionCollectively, the data provide evidence in favor of the hypothesis that patients with high PSMA uptake and high administered radionuclide dose correlate with a higher chance of response.
Designing and analyzing clinical trials for personalized medicine via Bayesian models
Authors: Zhang Chuanwu , Mayo Matthew S. , Wick Jo A. , Gajewski Byron J. 
Published: January 2021

AbstractPatients with different characteristics (e.g., biomarkers, risk factors) may have different responses to the same medicine. Personalized medicine clinical studies that are designed to identify patient subgroup treatment efficacies can benefit patients and save medical resources. However, subgroup treatment effect identification complicates the study design in consideration of desired operating characteristics. We investigate three Bayesian adaptive models for subgroup treatment effect identification: pairwise independent, hierarchical, and cluster hierarchical achieved via Dirichlet Process (DP). The impact of interim analysis and longitudinal data modeling on the personalized medicine study design is also explored. Interim analysis is considered since they can accelerate personalized medicine studies in cases where early stopping rules for success or futility are met. We apply integrated two‐component prediction method (ITP) for longitudinal data simulation, and simple linear regression for longitudinal data imputation to optimize the study design. The designs' performance in terms of power for the subgroup treatment effects and overall treatment effect, sample size, and study duration are investigated via simulation. We found the hierarchical model is an optimal approach to identifying subgroup treatment effects, and the cluster hierarchical model is an excellent alternative approach in cases where sufficient information is not available for specifying the priors. The interim analysis introduction to the study design lead to the trade‐off between power and expected sample size via the adjustment of the early stopping criteria. The introduction of the longitudinal modeling slightly improves the power. These findings can be applied to future personalized medicine studies with discrete or time‐to‐event endpoints.
Creativity in science: A dilemma for informal and formal education
Authors: Martins Gomes Diogo , McCauley Veronica 
Published: January 2021

AbstractInquiry learning pedagogies have not only been proposed as a successful teaching methodology to draw students into science, they are also rich with possibilities for creativity. The particular focus on investigations and problem‐solving provides opportunity for educators to embrace this. The primary curriculum explicitly values creativity in this regard, linking with inquiry, and problem‐solving. In recent years, science outreach carried out by universities in the Republic of Ireland has played a significant role in the formal classroom as a support to primary science (KS1). This article explores the perceptions of these two educators in the primary classroom, teachers (N = 31), and science outreach practitioners (N = 30), with respect to their theoretical stance on the construct of creativity and secondly their application of creativity in practice. The interview method used engaged research participants in a dialectical analysis of conceptual and pedagogical dilemmas. This unique, primarily qualitative methodology, provides evidence to differentiate perspectives of these two groups. Results indicate that participants generate new understandings by engaging in dialectical reflection and critical analysis of the two binaries. They also reveal that although outreach practitioners and teachers align in their perception of the theoretical model, that outreach practitioners are more favourable towards promoting a more creative environment for science in practice.
Core functions of Sustainable Human Resource Management. A hybrid literature review with the use of H‐Classics methodology
Authors: Piwowar‐Sulej Katarzyna 
Published: January 2021

AbstractThe key to a successful implementation of the idea of sustainable development in organizations is competent, motivated employees. Therefore, Human Resource Management (HRM) is of particular interest to practitioners and researchers. New HRM concepts that address emerging problems – such as sustainable HRM – arise and develop. The aim of this article is to answer the following research questions: What kind of issues are presented in the most cited articles in the field of sustainable HRM, taking into account the following division of HRM functions: recruitment and selection, performance appraisal, compensation, training and development, and HR flow? Which HRM functions require further research in the context of sustainable HRM? This study applies H‐Classics methodology and presents a hybrid literature review linking bibliometric characterization of the articles on sustainable HRM (including green HRM, socially responsible HRM, triple bottom line HRM, and common good HRM) with a manual review of those publications that made up the H‐Core of this research field. The most discussed HRM function was HR training, while the least discussed was HR flow. Moreover, HRM is mainly presented in relation to the environmental bottom line. Most of the cited papers present general guidance on how to shape individual functions of sustainable HRM and indicators for measuring the extent to which organizational practices are green. Research directions in H‐Core papers have been formulated toward all HRM functions, treated as a system and separately. The article also presents directions for additional research that were identified in the course of this study.
The Frustration Social Stressor for Adolescents (FSS‐A): A newly adapted psychosocial stressor
Authors: McKay Stacey L. , Fouladirad Saman , Cameron Catherine Ann 
Published: January 2021

AbstractThe role of stress on adolescents and its impact on development and mental health is of significant psychological concern. Previous research has investigated physiological changes, stressor characteristics and individual differences in stress responding. Experimental procedures that closely simulate naturally occurring psychosocial stressors have primarily been achievement‐related (e.g., test taking, competitive tasks and psychomotor performance) and anxiety‐provoking tasks (e.g., public speaking, improvisation and invasive medical‐procedures) but few seek to elicit frustration. To address this gap, a new experimental procedure was developed and validated against the Trier Social Stress Test for Teens, with a Low Stress condition as a control. Conflict‐related stressors, such as parent‐ and peer‐related debates, have been found to be effective in provoking frustration in adolescents. The Frustration Social Stressor for Adolescents (FSS‐A), a moderate frustration‐provoking stressor involves a peer debate on a ‘hot’ topic, followed by a serial subtraction task with still‐faced judges. The FSS‐A procedure effectively elicited reliable and valid physiological (cortisol, heart rate) stress responses and was an effective stressor for both sexes. This new, stress protocol mirrors frustrating‐ and anxiety‐provoking stressful situations that adolescents commonly encounter and affords a more detailed study of differential stress response patterns, increased understanding of adolescent stress, and potential for psychoeducational programming, such as directions for education and therapeutic intervention.
Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction
Authors: Sharma Poonam , Wang Xiaowei , Ming Clara Liu Chung , Vettori Laura , Figtree Gemma , Boyle Andrew , Gentile Carmine 
Published: January 2021

AbstractDespite the latest advances in cardiovascular biology and medicine, myocardial infarction (MI) remains one of the major causes of deaths worldwide. While reperfusion of the myocardium is critical to limit the ischemic damage typical of a MI event, it causes detrimental morphological and functional changes known as “reperfusion injury.” This complex scenario is poorly represented in currently available models of ischemia/reperfusion injury, leading to a poor translation of findings from the bench to the bedside. However, more recent bioengineered in vitro models of the human heart represent more clinically relevant tools to prevent and treat MI in patients. These include 3D cultures of cardiac cells, the use of patient‐derived stem cells, and 3D bioprinting technology. This review aims at highlighting the major features typical of a heart attack while comparing current in vitro, ex vivo, and in vivo models. This information has the potential to further guide in developing novel advanced in vitro cardiac models of ischemia/reperfusion injury. It may pave the way for the generation of advanced pathophysiological cardiac models with the potential to develop personalized therapies.
Transsib am Bodensee
Authors: Kuisle Anita 
Published: January 2021

AbstractIm Jahr 2019 musste die Eisenbahnbrücke bei Langenargen nach 120 Jahren Nutzung einem Neubau weichen. Diese Brücke über die Argen war im Wesentlichen im bauzeitlichen Zustand erhalten und bildete mit der benachbarten Straßenbrücke, der Kabelhängebrücke von 1898, ein unvergleichliches Ensemble. Die Konstruktionsweise der Langenargener Eisenbahnbrücke war für die Transsibirische Eisenbahn entwickelt worden.
Determining the optimum outrigger locations for steel tall buildings by using time history analyses
Authors: İnam İlhan Emre , Çeribaşı Seyit , Karapınar Işıl Sanrı 
Published: January 2021

SummaryThe outrigger system is an effective tall building system used at one or multiple locations of high‐rise buildings. It is designed to control and minimize lateral displacement and to increase bending stiffness of the buildings by changing the load transfer mechanism of the structural systems. This paper presents a framework for estimation of the optimum location of the outriggers with structural engineering design approach. Three different sample high‐rise buildings, 35‐story 140‐m, 40‐story 160‐m, and 45‐m 180‐m, were investigated. A time‐history analysis method was used to examine the effects of earthquakes. In the first stage, the buildings were assumed to have one outrigger. The outrigger was put on each floor, and ETABS analysis models were created. For each different sample buildings, 35, 40, and 45 different analytical models were utilized for that stage, respectively. In the second stage, in case of outrigger in two positions, all combinations in which outriggers can be located in different positions were taken into consideration for only 40‐story sample building. Considering all of the possible cases, where the steel high‐rise building has 40 floors and the outriggers can be in two different locations, 780 different analysis models were used.
Clients' perception of referral and veterinary specialists in a U.K. small animal referral hospital
Authors: Baud Koral U. , Treharne David R. , Soares Diana Gander , Burton Neil J. 
Published: January 2021

AbstractBackground: A 2011 RCVS report published following review of veterinary referral and specialisation suggested that the general public may have a lack of understanding of what constitutes specialisation. Our questionnaire study evaluated client understanding of the term ‘Specialist’ and the information obtained prior to referral.Methods: Questionnaires were completed prior to consultation. Client age, medical knowledge, how referral was initiated, options discussed by the primary care practice for treatment, expectations of the referral appointment, understanding of the term Specialist and what constitutes specialist training were assessed.Results: A total of 241 questionnaires were completed: 6.2% (15/241) of clients were working in the veterinary/medical industry; 52% (104/200) of clients assumed they were seeing a Specialist for consultation but only 49% (51/104) saw a Specialist; 0.4% (1/232) of owners correctly identified a Specialist as a clinician with a diploma, and incorrect definitions included having experience with a procedure or a postgraduate certificate; 13.6% (31/228) of clients identified that an internship and residency constituted Specialist training; and 66.8% (155/232) of clients had not researched the referral process.Conclusions: From the population sampled, a minority of clients understand the term Specialist and the postgraduate training this entails. Clients may erroneously assume they are receiving Specialist consultation.