bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative efficacy and acceptability of psychotherapies for panic disorder with or without agoraphobia: systematic review and network meta-analysis of randomised controlled trials
Authors: Papola Davide , Ostuzzi Giovanni , Tedeschi Federico , Gastaldon Chiara , Purgato Marianna , Del Giovane Cinzia , Pompoli Alessandro , Pauley Darin , Karyotaki Eirini , Sijbrandij Marit , Furukawa Toshi A. , Cuijpers Pim , Barbui Corrado 
Published: October 2021

BackgroundPsychotherapies are the treatment of choice for panic disorder, but which should be considered as first-line treatment is yet to be substantiated by evidence.AimsTo examine the most effective and accepted psychotherapy for the acute phase of panic disorder with or without agoraphobia via a network meta-analysis.MethodWe conducted a systematic review and network meta-analysis of randomised controlled trials (RCTs) to examine the most effective and accepted psychotherapy for the acute phase of panic disorder. We searched MEDLINE, Embase, PsycInfo and CENTRAL, from inception to 1 Jan 2021 for RCTs. Cochrane and PRISMA guidelines were used. Pairwise and network meta-analyses were conducted using a random-effects model. Confidence in the evidence was assessed using Confidence in Network Meta-Analysis (CINeMA). The protocol was published in a peer-reviewed journal and in PROSPERO (CRD42020206258).ResultsWe included 136 RCTs in the systematic review. Taking into consideration efficacy (7352 participants), acceptability (6862 participants) and the CINeMA confidence in evidence appraisal, the best interventions in comparison with treatment as usual (TAU) were cognitive–behavioural therapy (CBT) (for efficacy: standardised mean differences s.m.d. = −0.67, 95% CI −0.95 to −0.39; CINeMA: moderate; for acceptability: relative risk RR = 1.21, 95% CI −0.94 to 1.56; CINeMA: moderate) and short-term psychodynamic therapy (for efficacy: s.m.d. = −0.61, 95% CI −1.15 to −0.07; CINeMA: low; for acceptability: RR = 0.92, 95% CI 0.54–1.54; CINeMA: moderate). After removing RCTs at high risk of bias only CBT remained more efficacious than TAU.ConclusionsCBT and short-term psychodynamic therapy are reasonable first-line choices. Studies with high risk of bias tend to inflate the overall efficacy of treatments. Results from this systematic review and network meta-analysis should inform clinicians and guidelines.
Debris and Desire
Authors: Zhang Shunyuan 
Published: October 2021

AbstractThis article examines transgender practices in Southwest China through the analytic lens of assemblage. Through ethnographically contextualizing transgender sex workers' daily navigation of the rapidly shifting urban space in Kunming, this article reconceptualizes transgender as constitutive to the dynamic urban assemblage instead of carving out a space and time external to it. It argues that the critical lens of assemblage in the analysis of transgender practice reveals the constitutive queerness of the norm, troubling the political and analytic tenet of antinormativity in queer studies.
Proprotein convertase furina is required for heart development in zebrafish
Authors: Zhou Qinchao , Lei Lei , Zhang Hefei , Chiu Shih-Ching , Gao Lu , Yang Ran , Wei Wensheng , Peng Gang , Zhu Xiaojun , Xiong Jing-Wei 
Published: October 2021

ABSTRACT
Cardiac looping and trabeculation are key processes during cardiac chamber maturation. However, the underlying mechanisms remain incompletely understood. Here, we report the isolation, cloning and characterization of the proprotein convertase furina from the cardiovascular mutant loft in zebrafish. loft is an ethylnitrosourea-induced mutant and has evident defects in the cardiac outflow tract, heart looping and trabeculation, the craniofacial region and pharyngeal arch arteries. Positional cloning revealed that furina mRNA was barely detectable in loft mutants, and loft failed to complement the TALEN-induced furina mutant pku338, confirming that furina is responsible for the loft mutant phenotypes. Mechanistic studies demonstrated that Notch reporter Tg(tp1:mCherry) signals were largely eliminated in mutant hearts, and overexpression of the Notch intracellular domain partially rescued the mutant phenotypes, probably due to the lack of Furina-mediated cleavage processing of Notch1b proteins, the only Notch receptor expressed in the heart. Together, our data suggest a potential post-translational modification of Notch1b proteins via the proprotein convertase Furina in the heart, and unveil the function of the Furina-Notch1b axis in cardiac looping and trabeculation in zebrafish, and possibly in other organisms.
The Autophagy, Inflammation and Metabolism Center international eSymposium – an early-career investigators’ seminar series during the COVID-19 pandemic
Authors: Nieto-Torres Jose L. , Durgan Joanne , Franco-Romero Anais , Grumati Paolo , Guardia Carlos M. , Leidal Andrew M. , Mandell Michael A. , Towers Christina G. , Wang Fei 
Published: October 2021

ABSTRACT
The Autophagy, Inflammation and Metabolism (AIM) Center organized a globally accessible, virtual eSymposium during the COVID-19 pandemic in 2020. The conference included presentations from scientific leaders, as well as a career discussion panel, and provided a much-needed platform for early-career investigators (ECIs) to showcase their research in autophagy. This Perspective summarizes the science presented by the ECIs during the event and discusses the lessons learned from a virtual meeting of this kind during the pandemic. The meeting was a learning experience for all involved, and the ECI participants herein offer their thoughts on the pros and cons of virtual meetings as a modality, either as standalone or hybrid events, with a view towards the post-pandemic world.
Prenatal yolk corticosterone exposure promotes skeletal growth and induces oxidative imbalance in yellow-legged gull embryos
Authors: Romano Andrea , Possenti Cristina Daniela , Caprioli Manuela , De Felice Beatrice , Rubolini Diego , Parolini Marco 
Published: October 2021

ABSTRACT
Maternally derived hormones induce variation in offspring phenotype, with consequences that can carry over into post-natal life and even into adulthood. In birds, maternal egg corticosterone (CORT) is known to exert contrasting effects on offspring morphology, physiology and behaviour after hatching. However, information on the effects of CORT exposure on pre-hatching embryonic development is limited. We experimentally increased yolk CORT levels in yellow-legged gull (Larus michahellis) eggs, and assessed the effects on embryo pre-hatching development and oxidative status of brain and liver. CORT-supplemented embryos reached a larger skeletal size and liver mass compared with controls. Embryos from CORT-injected last-laid eggs showed decreased activity of the hepatic antioxidant enzymes superoxide dismutase and catalase, while intermediate-laid eggs showed increased levels of lipid peroxidation. However, elevated yolk CORT did not affect oxidative stress endpoints in the brain. Our results indicate that elevated yolk CORT levels affect prenatal embryo development by promoting skeletal growth, and induce laying sequence- and organ-specific oxidative imbalance, with potential adverse consequences during postnatal life, especially for late-hatched offspring.
Role of MRI in diagnosing the primary site of origin in indeterminate cases of uterocervical carcinomas: a systematic review and meta-analysis
Authors: Jain Pooja , Aggarwal Ankita , Ghasi Rohini Gupta , Malik Amita , Misra Ritu Nair , Garg Kanwaljeet 
Published: October 2021

Objective:
To perform a literature review assessing role of MRI in predicting origin of indeterminate uterocervical carcinomas with emphasis on sequences and imaging parameters.

Methods:
Electronic literature search of PubMed was performed from its inception until May 2020 and PICO model used for study selection; population was female patients with known/clinical suspicion of uterocervical cancer, intervention was MRI, comparison was by histopathology and outcome was differentiation between primary endometrial and cervical cancers.

Results:
Eight out of nine reviewed articles reinforced role of MRI in uterocervical primary determination. T2 and Dynamic contrast were the most popular sequences determining tumor location, morphology, enhancement, and invasion patterns. Role of DWI and MR spectroscopy has been evaluated by even fewer studies with significant differences found in both apparent diffusion coefficient values and metabolite spectra. The four studies eligible for meta-analysis showed a pooled sensitivity of 88.4% (95% confidence interval 70.6 to 96.1%) and a pooled specificity of 39.5% (95% confidence interval 4.2 to 90.6%).

Conclusions:
MRI plays a pivotal role in uterocervical primary determination with both conventional and newer sequences assessing important morphometric and functional parameters. Socioeconomic impact of both primaries, different management guidelines and paucity of existing studies warrants further research. Prospective multicenter trials will help bridge this gap. Meanwhile, individual patient database meta-analysis can help corroborate existing data.

Advances in knowledge:
MRI with its classical and functional sequences helps in differentiation of the uterine ‘cancer gray zone’ which is imperative as both primary endometrial and cervical tumors have different management protocols.
Performance of a convolutional neural network algorithm for tooth detection and numbering on periapical radiographs
Authors: Görürgöz Cansu , Orhan Kaan , Bayrakdar Ibrahim Sevki , Çelik Özer , Bilgir Elif , Odabaş Alper , Aslan Ahmet Faruk , Jagtap Rohan 
Published: October 2021

Objectives: The present study aimed to evaluate the performance of a Faster Region-based Convolutional Neural Network (R-CNN) algorithm for tooth detection and numbering on periapical images. Methods: The data sets of 1686 randomly selected periapical radiographs of patients were collected retrospectively. A pre-trained model (GoogLeNet Inception v3 CNN) was employed for pre-processing, and transfer learning techniques were applied for data set training. The algorithm consisted of: (1) the Jaw classification model, (2) Region detection models, and (3) the Final algorithm using all models. Finally, an analysis of the latest model has been integrated alongside the others. The sensitivity, precision, true-positive rate, and false-positive/negative rate were computed to analyze the performance of the algorithm using a confusion matrix. Results: An artificial intelligence algorithm (CranioCatch, Eskisehir-Turkey) was designed based on R-CNN inception architecture to automatically detect and number the teeth on periapical images. Of 864 teeth in 156 periapical radiographs, 668 were correctly numbered in the test data set. The F1 score, precision, and sensitivity were 0.8720, 0.7812, and 0.9867, respectively. Conclusion: The study demonstrated the potential accuracy and efficiency of the CNN algorithm for detecting and numbering teeth. The deep learning-based methods can help clinicians reduce workloads, improve dental records, and reduce turnaround time for urgent cases. This architecture might also contribute to forensic science.
Universidades e Internacionalização Da Educação Superior Para a Integração Regional: A Agenda Educacional Mercosul e As Mobilidades De Estudantes Brasileiros Para a Argentina l Universities And The Internationalization Of Higher Education Towards Regional Development: The Educational Agenda In Mercosur And The Student Mobility Between Brazil And Argentine
Authors: Lajus Fernando 
Published: October 2021

A universidade tem sido uma das instituições centrais no desenvolvimento das sociedades modernas, com os últimos 30 anos vendo o surgimento de dinâmicas de internacionalização da educação superior como um imperativo para o seu progresso. Exploramos a relação deste processo com o tema da integração regional, tomando como exemplo o MERCOSUL enquanto espaço geográfico e de decisão. Para tanto, focamos nos dados que contam a história da relação entre as universidades brasileiras e argentinas desde um ponto de vista dos processos de internacionalização, em que atentamos para a existência de dinâmicas de mobilidade informais que passam despercebidas pelas estratégias de políticas de cooperação acadêmica. Discutimos como essas experiências de estudantes brasileiros na Argentina podem auxiliar na construção de uma agenda educacional no MERCOSUL que leve em conta dois pontos principais: a fatura de um sistema de acreditação comum para cursos e o incremento de programas de mobilidade científica na região.Palavras-Chave: Internacionalização da Educação Superior; Integração Regional; MERCOSUL.ABSTRACTThe university has been one of the central institutions in the development of modern societies, with the last 30 years seeing the emergence of internationalization of higher education as an imperative for its progress. We explore the relation of such a process with the theme of regional cooperation, taking MERCOSUL as an example of a geographical space of decision-making. We focus on the data regarding the history between the Brazilian and Argentine universities from the point of view of its process of internationalization, where we pay attention to the existence of informal dynamics that do not get into consideration in the politics of regional cooperation. We discuss how the experience of Brazilian students in Argentine can support the construction of an education agenda in MERCOSUL that takes into account two key aspects: the architecture of a common system of accreditation and the manufacturing of programs of scientific mobility in the region.Keywords: Internationalization of Higher Education; Regional Cooperation; MERCOSUR. Recebido em: 04/02/2021 | Aceito em: 07/05/2021.
A Economia Política do Big Data: Um Recurso Estratégico e de Poder entre Oligopólios Tecnológicos e Vulnerabilidades Estatais l The Political Economy of Big Data: a Strategic and Power Resource Among Technological Oligopolies and State Vulnerabilities
Authors: Marzinotto Junior Francisco Luiz 
Published: October 2021

A Internet popularizou-se globalmente a partir da década de 90 e se tornou central nas relações sociais contemporâneas. Atualmente, mais de 50% da população mundial a utiliza diariamente. Com isso, a quantidade de dados digitais produzidos aumentou subitamente, fazendo com que adentremos na “Era do Big Data”. Contudo, essa área é dominada por oligopólios privados com enorme capital que absorvem novas empresas e tecnologias, eliminando possíveis concorrentes e colocando em risco a estabilidade estatal. Assim, o objetivo do presente trabalho é analisar a posição dos Estados em relação à “Era do Big Data”. Os resultados demonstraram a existência de um ciclo vicioso de concentração de informações sensíveis e poder político-econômico em oligopólios. Conclui-se que os “dados” não devem ser vistos apenas como uma ferramenta de aprimoramento comercial, mas sim, como uma fonte de recurso estratégico aos Estados, devendo-se priorizar os interesses públicos em detrimento dos privados em sua gestão.Palavras-Chave: Big Data; Poder; Economia Política Internacional. ABSTRACTInternet became globally popular and central to social relations since 1990s. Currently, more than 50% of the world’s population uses it daily. As result, the amount of digital data produced has suddenly increased, making us enter the “Big Data Era”. However, this area is dominated by private oligopolies with huge capital that absorb new companies and technologies, eliminating potential competitors and putting state stability at risk. Thus, the objective of the present work is to analyze the position of the States in relation to the “Big Data Era”. The results demonstrated the existence of a vicious cycle of concentration of sensitive information and political-economic power in oligopolies. It is concluded that big data should no longer be seen only as a tool for commercial improvement, but rather as a source of strategic resources for States, where public interests should be prioritized over private ones in their management.Keywords: Big Data; Power; International Political Economy. Recebido em: 10/04/2021 | Aceito em: 07/07/2021.
Mapping the genealogy of medical device predicates in the United States
Authors: Pai Dhruv B. 
Published: October 2021

Background
In the United States, medical devices are regulated and subject to review by the Food and Drug Administration (FDA) before they can be marketed. Low-to-medium risk novel medical devices can be reviewed under the De Novo umbrella before they can proceed to market, and this process can be fairly cumbersome, expensive, and time-consuming. An alternate faster and less-expensive pathway to going to market is the 510(k) pathway. In this approach, if the device can be shown to be substantially equivalent in safety and effectiveness to a pre-existing FDA-approved marketed device (or “predicates”), it can be cleared to market. Due to the possibility of daisy-chaining predicate devices, it can very quickly be difficult to unravel the logic and justification of how a particular medical device’s equivalence was established. From patients’ perspective, this minimizes transparency in the process. From a vendor perspective, it can be difficult to determine the right predicate that applies to their device.

Methods
We map the connectivity of various predicates in the medical device field by applying text mining and natural language processing (NLP) techniques on data publicly made available by the FDA 78000 device summaries were scraped from the US FDA 510(k) database, and a total of 2,721 devices cleared by the 510(k) regulatory pathway in 2020 were used as a specific case study to map the genealogy of medical devices cleared by the FDA. Cosine similarity was used to gauge the degree of substantial equivalence between two medical devices by evaluating their device descriptions and indications for use. Recalls and complaints for predicate devices were extracted from the FDA’s Total Product Life Cycle database using html scraping and web page optical character recognition to determine the similarity between class 1 recalled devices (the most severe form of device recall) and other substantially equivalent devices. A specific product code was used to illustrate the mapping of the genealogy from a De Novo device.

Results and discussion
The ancestral tree for the medical devices cleared in 2020 is vast and sparse, with a large number of devices having only 1–2 predicates. Evaluation of substantial equivalence data from 2003–2020 shows that the standard for substantial equivalence has not changed significantly. Studying the recalls and complaints, shows that the insulin infusion pump had the highest number of complaints, yet none of the recalled devices bore significant degree of text similarity to currently marketed devices. The mapping from the De Novo device case study was used to develop an ancestry map from the recalled predicate (recalled due to design flaws) to current substantially equivalent products in the market.

Conclusions
Besides enabling a better understanding of the risks and benefits of the 510(k) process, mapping of connectivity of various predicates could help increase consumer confidence in the medical devices that are currently in the marketplace.
Políticas locales de Economía Social y Solidaria: aportes para el análisis de las iniciativas desarrolladas por la Municipalidad de Santa Fe entre los años 2011-2019
Authors: Sotto Orlando 
Published: October 2021

El presente artículo tiene por finalidad describir las políticas y programas locales de Economía Social y Solidaria (en adelante ESS) que la Municipalidad de Santa Fe implemento entre los años 2011-2019 e indagar si dichas acciones y actividades contribuyeron al fortalecimiento y sostenibilidad de las prácticas de ESS locales.
Si bien en estos años la ESS ha adquirido mayor visibilidad social y política en diversos países y regiones del mundo, por lo general, su institucionalización en el ámbito del Estado local ha sido débil o inexistente.
Se destaca que la Municipalidad de Santa Fe desarrollo una diversidad de acciones que de una u otra manera estaban relacionados a la ESS, tratando de incluir un conjunto heterogéneo de actores dentro de las mismas (cooperativas de trabajo, emprendedores sociales, recicladores, jóvenes desempleados, entre otros) que estaban excluidos o que tenían dificultades para insertarse en el mercado laboral y económico. En este sentido, si bien hubo un proceso de institucionalización de la ESS por parte del gobierno local, los destinatarios de las políticas de ESS continúan con dificultades para lograr la sostenibilidad integral de sus emprendimientos y trayectorias socio productivas.
Peculiarities of ultrasound diagnostics of paraurethral glands in women of fertile age
Authors: Grygorenko V. M. , Romashchenko O. V. , Biloholovska V. V. , Kosiukhno M. O. , Melnykov S. M. , Klius A. L. 
Published: October 2021

Aim. Evaluation of ultrasound diagnostics of paraurethral glands considering their types of location in women of fertile age.
Materials and methods. A gynaecological, sexological and ultrasound study of 94 women in the age from 24 to 42 (average age 31.01 ± 6.60) was carried out.
Determination of paraurethral glands during ultrasound study was conducted in the format of grey scale (B-mode) using the Doppler colour flow mapping and evaluation of Doppler indices of paraurethral glands both before and after sexual stimu­lation. To optimize the paraurethral glands visual view at the beginning of examination urinary bladder was catheterized and a balloon, filled with gel, was inserted into vagina.
Results. The front type of paraurethral glands location was found in the accumulation of glandular tissues in regard to the distal part of urethra in 67 (71.2 %) of the examined, back type – in the area of back urethra in 19 (20.2 %), diffuse type – along urethra in 7 (7.5 %) and absence – in 1 (1.1 %). Paraurethral glands were visualized in the form of clear isoechogenic oval formation with the following dimensions: length – 2.20 ± 0.60 cm, width – 1.52 ± 0.40 cm, thickness – 1.30 ± 0.30 cm, and volume – 4.75 ± 0.50 cm3.
The diameter of vessels in the paraurethral glands area was between 0.17 cm and 0.21 cm in calm state and 0.39–0.41 cm – during stimulation. Maximum systolic speed of blood flow (Vps) in calm was 8.9–11.1 cm/sec, while in sexual stimulation it was 13.9–14.1 cm/sec, resistance index (IR) – 0.60–0.62 and 0.63–0.68, respectively, pulsation index (IP) – 1.22–1.44 and 1.61–1.72, respectively.
Conclusions. The ultrasound study of vessels of paraurethral glands, when Doppler method is used according to the suggested methodology, gives the opportunity not only to identify its anatomical structure, but also to determine its types. In CDC the increase of diameter of vessels and the optimization of vessels image in the area of paraurethral glands in case of sexual stimulation were marked.