bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trigeminal neuropathy causes hypomyelination in the anterior cingulate cortex, disrupts the synchrony of neural circuitry, and impairs decision‐making in male rats
Authors: Murugappan Suresh K. , Hasan Mahadi , Lei Zhuogui , Iqbal Zafar , Ramkrishnan Aruna S. , Wong Heung Y. , Li Ying 
Published: July 2021

AbstractInfraorbital nerve‐chronic constriction injury (ION‐CCI) has become the most popular chronic trigeminal neuropathic pain (TNP) injury animal model which causes prolonged mechanical allodynia. Accumulative evidence suggests that TNP interferes with cognitive functions, however the underlying mechanisms are not known. The aim of this study was to investigate decision‐making performance as well as synaptic and large‐scale neural synchronized alterations in the spinal trigeminal nucleus (SpV) circuitry and anterior cingulate cortex (ACC) neural circuitry in male rats with TNP. Rat gambling task showed that ION‐CCI led to decrease the proportion of good decision makers and increase the proportion of poor decision makers. Electrophysiological recordings showed long‐lasting synaptic potentiation of local field potential in the trigeminal ganglia‐SpV caudalis (SpVc) synapses in TNP rats. In this study, TNP led to disruption of ACC spike timing and basolateral amygdala (BLA) theta oscillation associated with suppressed synchronization of theta oscillation between the BLA and ACC, indicating reduced neuronal communications. Myelination is critical for information flow between brain regions, and myelin plasticity is an important feature for learning. Neural activity in the cortical regions impacts myelination by regulating oligodendrocyte (OL) proliferation, differentiation, and myelin formation. We characterized newly formed oligodendrocyte progenitor cells, and mature OLs are reduced in TNP and are associated with reduced myelin strength in the ACC region. The functional disturbances in the BLA‐ACC neural circuitry is pathologically associated with the myelin defects in the ACC region which may be relevant causes for the deficits in decision‐making in chronic TNP state.
Strength and physical activity in osteoarthritis: The mediating role of kinesiophobia
Authors: Aydemir Burcu , Huang Chun‐Hao , Foucher Kharma C. 
Published: July 2021

AbstractThe aim of this study was to investigate the association between muscle strength and physical activity level in people with knee osteoarthritis (OA), and determine whether this association is mediated by pain‐related fear of movement (kinesiophobia) and self‐reported pain. Cross‐sectional data from 37 subjects (age 58.8 ± 8.6 years, 25F/12M, BMI 33.5 ± 6.4 kg/m2) with OA of the knee were used. Isometric knee extensor and flexor muscle strength were measured using an isokinetic dynamometer. Physical activity, kinesiophobia, and pain were assessed by self‐report using the University of California, Los Angeles activity rating scale, Tampa Scale for Kinesiophobia, and The Knee Injury and Osteoarthritis Outcome Score pain subscale, respectively. The associations between strength measures, physical activity, kinesiophobia, and pain scores, were modeled by performing a parallel multiple mediation analysis and the significance of mediational effects (kinesiophobia and pain) were tested using a bootstrap approach. Lower knee flexion and extension strength were associated with lower physical activity scores and these relationships were mediated by higher kinesiophobia scores (more fear) but not pain scores. Knee extension strength was directly associated with physical activity scores after controlling for kinesiophobia and pain scores. These results suggest that muscle strength can influence physical activity directly and indirectly through fear of movement. Assessing these measures together in this population may help clinicians identify patients that are more likely to avoid physical activities due to not only muscle weakness but also fear of movement.
Isolation, screening and identification of key components having intense insect repellent activity against Plodia interpunctella from four different medicinal plant materials
Authors: Lee Jung‐Soo , Lee Junhyuk , Choi Inyoung , Chang Yoonjee , Yoon Chan Suk , Han Jaejoon 
Published: July 2021

AbstractBACKGROUNDGlobal warming and the indiscriminate use of pesticides have increased the propagation of the stored‐product insect pests, leading to enormous losses in the agriculture and food industries. The most used insect repellents are synthetic derivatives; however, these have an adverse effect on human health as well as on the environment. Therefore, we attempted to find materials with insect repellent activity in natural products. The present study aimed to identify the single chemical component with intense insect repellent activity in extracts from four different Oriental medicinal plant materials: (i) Anethum graveolens L. (dill) seeds; (ii) Artemisia capillaris Thunb. (capillary wormwood) leaves; (iii) smoked Prunus mume Siebold & Zucc. (mume) fruits; and (iv) Rhus javanica L. (galls).RESULTSAs a result of the bioassay‐guided fractionation of each extract against the Plodia interpunctella, stored‐product insect, the n‐hexane fraction of dill seeds extract was confirmed as the optimal fraction between all of the fractions. In total, 32 chemical components were identified from the n‐hexane fraction of dill seeds by gas chromatography‐mass spectrometry analysis, and the two main components were dillapiole (47.51%) and carvone (26.76%). Of the two components, dillapiole was confirmed as the key component playing an essential role in insect repellent activity.CONCLUSIONOur study suggests that dillapiole has the potential to be used as a natural insect repellent for the control of P. interpunctella infestation in agricultural and food products during distribution and storage. © 2021 Society of Chemical Industry.
Bioactive compounds of mango (Mangifera indica): a review of extraction technologies and chemical constituents
Authors: Quintana Somaris E , Salas Stephanie , García‐Zapateiro Luis A 
Published: July 2021

AbstractMango (Mangifera indica) has been recognized as a rich source of bioactive compounds with potential pharmaceutical and nutraceutical applications and has attracted increasing interest from research. Phytochemistry studies have demonstrated that phenolic compounds are one of the most important biologically active components of M. indica extracts. Ultrasound‑ and microwave‐assisted extractions and supercritical fluids have been employed to obtain bioactive molecules, such as phenolic acids, terpenoids, carotenoids, and fatty acids. These phytochemicals exhibit antioxidant, antimicrobial, anti‐inflammatory, and anticancer activity, and depending on the source (bark, leaves, seeds, flowers, or peel) and extraction method there will be differences in the structure and bioactivity. This review examines the bioactive compounds, extraction techniques, and biological function of different parts of M. indica of great importance as nutraceuticals and functional compounds with potential application as therapeutic agents and functional foods. © 2021 Society of Chemical Industry.
The effect of neoadjuvant imatinib therapy on outcome and survival in rectal gastrointestinal stromal tumors: A multiinstitutional study
Authors: Yang Wenchang , Liu Qian , Lin Guole , Zhang Bo , Cao Hui , Zhao Yan , Xia Lijian , Feng Fan , Xiong Zhiguo , Hu Junbo , Ye Yingjiang , Tao Kaixiong , Zhang Peng 
Published: July 2021

AbstractBackground and ObjectivesThis study aimed to characterize the efficacy of neoadjuvant imatinib in rectal gastrointestinal stromal tumors (GISTs) and the prognostic characteristics of patients after surgery.MethodsPatients with rectal GISTs who received neoadjuvant imatinib between 2000 and 2019 were selected from 11 large‐scale tertiary hospitals in China. The best response to neoadjuvant imatinib was assessed. Propensity score matching (PSM) was conducted to reduce confounders. Recurrence free survival (RFS) and overall survival (OS) were estimated using Kaplan–Meier method.ResultsOf the 100 patients, 75, 18, and 7 had a partial response (PR), stable disease (SD), and progressive disease (PD), respectively. The median tumor size decreased from 5 cm before treatment to 4 cm after treatment (p < 0.001). A total of 31 patients underwent genetic testing after surgery; 23 of patients with exon 11 mutation had PR and 2 had SD. One of the patients with exon 9 mutation had PR, 2 had SD, and 1 had PD. Two patients with the wild type GIST had PD. A total of 86 patients underwent surgery of which 85 underwent complete resection; 72 underwent anal preservation and 40 underwent local excision (LE). After PSM, patients who received neoadjuvant therapy had higher rates of LE (p = 0.001) and anal preservation (p = 0.033) than those of patients without neoadjuvant therapy. The median follow‐up time was 37 months. Nine patients experienced recurrence and one patient died. The 3‐year RFS and OS rates were 95.0% and 100%, respectively. After PSM, we found that there was no significant difference in RFS between patients who received or did not receive neoadjuvant therapy (p = 0.623). Univariate analysis showed postneoadjuvant tumor size (p = 0.469) and mitotic count (p = 0.294) were not associated with the RFS in patients who received neoadjuvant imatinib.ConclusionsNeoadjuvant imatinib can shrink rectal GIST size, increasing the possibility of complete resection and anal preservation. Further studies are warranted to understand the long‐term outcomes of rectal GISTs in patients receiving neoadjuvant imatinib.
Outcomes of the keystone perforator island flap for oncologic reconstruction of the back
Authors: Yan Maria , Rose Peter S. , Houdek Matthew T. , Moran Steven L. 
Published: July 2021

AbstractBackgroundCoverage of posterior trunk defects after tumor resection can be challenging due to the intricate anatomy. The keystone perforator island flap (KPIF) provides coverage of the defect without the need for distant flap coverage or microsurgery, matches the recipient's skin color and contour, and requires a short operative time.MethodsA retrospective review of all oncological back reconstructions with KPIF was performed at our institution. The patient comorbidities and surgical outcomes were collected.ResultsA total of 17 patients underwent 20 KPIF (15 single and 2 double) for back reconstruction. Surgical indications were sarcoma (n = 12) and melanoma (n = 5). The mean age at surgery was 47.3 years (SD 23.3). The flaps were located in the upper back (n = 8), paraspinal (n = 4), middle back (n = 6), and lower back (n = 2). The average wound size after sarcoma and melanoma excision were 231.6 ± 297.4 and 156.7 ± 269.7 cm2, respectively. Four patients required an additional planned skin graft and one patient underwent a simultaneous myocutaneous latissimus dorsi flap. The mean operative time, including tumor resection, was 256 min (SD 118). The median length‐of‐hospital stay was 3 days (Q1–3: 1–6.5) and the median follow‐up time was 35.3 months (Q1–3: 13.3–53.1). All flaps survived with minor surgical complications which included hematoma (n = 1), surgical site infection requiring debridement (n = 1), superficial wound dehiscence (n = 1), cellulitis (n = 1), and seroma (n = 1). The reconstructions were successful in 100% of patients.ConclusionsThe KPIF is a reliable and safe option for reconstruction of oncological back defects with minimal perioperative complications. This flap option avoids the use of free flaps and myocutaneous flaps for moderate‐sized back defects.
Influence of Landscape Characteristics on Hunter Space Use and Success
Authors: Rowland Mary M. , Nielson Ryan M. , Wisdom Michael J. , Johnson Bruce K. , Findholt Scott , Clark Darren , Didonato Guy T. , Hafer Jennifer M. , Naylor Bridgett J. 
Published: July 2021

ABSTRACTSport hunting of ungulates is a predominant recreational pursuit and the primary tool for managing their populations in North America and beyond, given its influence on ungulate distributions, social organization, and population performance. Similarly, land management, such as motorized vehicle access, influences ungulate distributions during and outside hunting seasons. Although research on ungulate responses to hunting and land use is widespread, knowledge gaps persist about space use of hunters and what landscape features discriminate among hunt types and between successful and unsuccessful hunters. We used telemetry location data from hunters (n = 341) to estimate space use from 2008–2013 during 3 types of controlled, 5‐day hunts for antlered mule deer (Odocoileus hemionus) and elk (Cervus canadensis) in northeastern Oregon, USA: archery elk, rifle deer, and rifle elk. To evaluate space use, we developed utilization distributions for each hunter, created core areas (50% contours) for groups of hunters, and derived several metrics of space‐use overlap between successful and unsuccessful hunters. We also modeled predictors of space use using resource utilization functions with beta regression and stepwise model building. Hunter space use was compressed, with even the largest core area (unsuccessful rifle elk hunters) encompassing <16% (1,178 ha) of the area. We found strong similarities in space use of rifle hunters compared to archers, and core areas of successful hunters were markedly smaller than those of unsuccessful hunters (e.g., = 104 ha vs. 681 ha, respectively, for archers). Percentage cover and distance from open roads were the most consistent covariates in the 6 final models (successful vs. unsuccessful for each of 3 hunts) but with different signs. For example, predicted use of archery and rifle elk hunters increased with cover but decreased for rifle deer hunters. Although the same covariates were in the final models for unsuccessful and successful rifle elk hunters, their negligible spatial overlap suggested they sought those features in different locales, a pattern also documented for rifle deer hunters. Our models performed well (Spearman's rank correlation coefficients = 0.99 for 5 of 6 models), reflecting their utility for managing hunters and landscapes. Our results suggest that strategic management of open roads and forest cover can benefit managers seeking to balance hunter opportunity and satisfaction with harvest objectives, especially for species of special concern such as mule deer, and that differences in space use among hunter groups should be accounted for in hunting season designs. © 2021 The Wildlife Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Honorific authorship and approval of the ICMJE criteria: A survey with a convenience sample
Authors: Ashkenazi Itamar , Olsha Oded 
Published: July 2021

AbstractA 10‐question survey was distributed by email to 382 academic professionals involved in biomedical research in order to evaluate their experience with honorific authorship, author displacement, and the perceived validity of the International Committee of Medical Journal Editors (ICMJE) requirements. 104 (27%) responded to the survey collected without identifiers. 92% (95/104) were physicians, and 75% (78/104) reported ≥11 publications as co‐authors. 68% (69/101) thought honorific authorship was commonly (>20% of the publications) practiced in their workplace and/or research environment. Honorific authorship was perceived as commonly awarded to superiors by 63% (65/104) and to peers by 50% (51/103). Only 36% (37/104) reported rarely (≤5 of the publications) or never being a co‐author in a manuscript in which honorific authorship was awarded. 33% (34/103) reported that they commonly experienced co‐authors being displaced from their appropriate rank in the sequence of authors due to honorific authorship. Only 31% (32/104) condemned honorific authorship and only 36% (37/104) agreed all four authorship criteria set by the ICMJE should be complied with. Those who condemned honorific authorship more commonly accepted complying with all four ICMJE criteria (18/32 vs. 19/72; p = 0.004). Increasing experience with author displacement was not associated with the condemnation of honorific authorship (p = 0.35).
Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications
Authors: Mallah Khalil , Zibara Kazem , Kerbaj Coline , Eid Ali , Khoshman Nour , Ousseily Zahraa , Kobeissy Abir , Cardon Tristan , Cizkova Dasa , Kobeissy Firas , Fournier Isabelle , Salzet Michel 
Published: July 2021

AbstractTraumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation as well as military‐related practices. This type of central nervous system trauma is known to predispose patients to several neurological disorders such as Parkinson's disease, Alzheimer's disease, chronic trauamatic encephalopathy, and age‐related Dementia. Recently, several proteomic and lipidomic platforms have been applied on different TBI studies to investigate TBI‐related mechanisms that have broadened our understanding of its distinct neuropathological complications. In this study, we provide an updated comprehensive overview of the current knowledge and novel perspectives of the spatially resolved microproteomics and microlipidomics approaches guided by mass spectrometry imaging used in TBI studies and its applications in the neurotrauma field. In this regard, we will discuss the use of the spatially resolved microproteomics and assess the different microproteomic sampling methods such as laser capture microdissection, parafilm assisted microdissection, and liquid microjunction extraction as accurate and precise techniques in the field of neuroproteomics. Additionally, we will highlight lipid profiling applications and their prospective potentials in characterizing molecular processes involved in the field of TBI. Specifically, we will discuss the phospholipid metabolism acting as a precursor for proinflammatory molecules such as eicosanoids. Finally, we will survey the current state of spatial neuroproteomics and microproteomics applications and present the various studies highlighting their findings in these fields.
A rohitukine derivative IIIM‐290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells
Authors: Mintoo Mubashir , Khan Sameer , Wani Abubakar , Malik Sumera , Bhurta Deendyal , Bharate Sandip , Malik Fayaz , Mondhe Dilip 
Published: July 2021

AbstractRohitukine, a chromone alkaloid extracted from Dysoxylum binectariferum, has a propitious anticancer activity. Our previous study shows that a new Rohitukine derivative IIIM‐290 restricts the growth of pancreatic cancer in vivo and in vitro. In the present findings, we report the mechanism of cell death induced by IIIM‐290 in MOLT‐4 cells (acute lymphoblastic leukemia) and its anticancer potential against various murine leukemic tumor models in vivo. We found that IIIM‐290 induced apoptosis through upregulation of different apoptotic proteins like PUMA, BAX, cytochrome c, cleaved (active) caspase‐3, and cleaved PARP in MOLT‐4 cells. Moreover, IIIM‐290 abated mitochondrial membrane potential, elevated calcium levels, reactive oxygen species, and arrested growth of MOLT‐4 cells in the synthesis (S) phase of the cell cycle. Interestingly, the elevation in proapoptotic markers was p53 dependent—the silencing of p53 abrogated apoptosis (programmed cell death) triggered by IIIM‐290 in MOLT‐4 cells. Furthermore, IIIM‐290 significantly enhanced the survival of animals with P388 and L1210 leukemia. Thus, our results put IIIM‐290 as a potential candidate for the anticancer lead.
Power divider with wideband harmonic suppression for center‐fed antenna arrays
Authors: Shanmugam Bhaskar Vignesh , Tan Eng Leong 
Published: July 2021

AbstractIn this paper, a center‐fed four‐way power divider with wideband harmonic suppression is proposed. A distinguishing feature is the use of sectorially modified Gielis curves (SMGCs) for open stubs, shorted stubs, and stub‐loaded coupled‐line structures, providing more degrees of freedom in the designs to suppress the wideband harmonics. The expressions for the SMGCs, along with the ABCD matrix elements of the stub‐loaded coupled‐line structure having different even and odd mode electrical lengths (θec ≠ θoc) are another distinguishing features presented in this work. The novelty is to use two stages (first and second) with a combination of open, shorted, coupled‐line stubs and tapered transmission lines to achieve good impedance matching and wideband harmonic suppression for center‐fed antenna arrays. The proposed center‐fed four‐way power divider achieves a wideband harmonic suppression of up to 4fo and a relatively wide −10 dB impedance bandwidth of 52%. The proposed power divider is used in a horizontally‐polarized antenna array for wireless L‐band applications.
An ultra‐wideband bandstop filter with circularly etched stub resonator
Authors: Rajput Anil , Chauhan Monika , Mukherjee Biswajeet 
Published: July 2021

AbstractIn this letter, an ultra‐wide band bandstop filter (BSF) with three transmission zeros and one reflection zero is presented. The role of the circular etched shaped stub as a notch pass response is investigated. Further, a compact size of 13 mm × 24.30 mm (0.219λg× 0.410λg) is achieved by employing an interdigital capacitor to increase coupling between the lines. Furthermore, the transmission line model of the filter is proposed, and consequently even and odd mode impedance is calculated analytically. The proposed filter offers an ultra‐wide bandwidth of 6.1 GHz (3.7 GHz‐9.8 GHz) with a rejection depth of 20 dB over the entire rejection band. Moreover, the upper skirt factor of 47.2 dB per GHz is achieved. A prototype of the proposed BSF is fabricated and measured. Simulated and measured results are in good agreement which validates the proposed design.
Adult Sockeye Salmon Responses to Transplanting Upstream of an Impassable Dam
Authors: Kock Tobias J. , Evans Scott D. , Saluskin Brian P. , Matala Andrew P. , Visser Richard , Johnston Mark V. , Galbreath Peter F. , Pope Adam C. 
Published: July 2021

Abstract
The Yakama Nation manages a program for reintroducing Sockeye Salmon Oncorhynchus nerka upstream of Cle Elum Dam in the Yakima River basin. The program involves transplanting of a mix of adult Sockeye Salmon from two middle Columbia River donor stocks, Lake Wenatchee (WEN) and Osoyoos Lake (OSO), with the goal of establishing a self-sustaining population in the basin. In 2017, a subset of the transplanted population was radio-tagged and monitored to assess stock-specific responses to transplanting, including downstream entrainment at Cle Elum Dam (“fallback”) and prespawn mortality. Tagged fish were active during the first 2 weeks after release. Some fish moved upstream into the Cle Elum River and then returned to the reservoir; other fish moved downstream and passed Cle Elum Dam. Movement within the study area diminished during August but increased in September when fish began migrating up the Cle Elum River for spawning. A greater proportion of WEN fish (76.3%) was detected entering the river compared to OSO fish (53.9%). The hazard ratio from a multistate analysis of fish behavior indicated that WEN fish were nine times more likely to enter the river than OSO fish. The WEN fish also initiated upstream movement 3 weeks earlier than OSO fish. We found that 27.0% of all tagged fish were lost to the spawning population through fallback (20.7%) and prespawn mortality (6.3%). Fallback and prespawn mortality occurred for a greater percentage of OSO fish (26.9% and 7.7%) than WEN fish (15.3% and 5.1%), but these differences were not statistically different. These results provide foundational information from the early phase of a reintroduction effort. Continued monitoring will be required as Sockeye Salmon evolve to conditions upstream of Cle Elum Dam, and results from these efforts will provide valuable insights for this reintroduction effort and others in river systems with similar characteristics.