bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Achievements about Targeted Alpha Therapy-Based Targeting Vectors and Chelating Agents
Authors: Alvandi Maryam , Farzipour Soghra , Shaghaghi Zahra , Abbasi Sahar , Albooyeh Hajar 
Published: July 2021

:
One of the most rapidly growing options in the management of cancer therapy is Targeted Alpha Therapy
(TAT) through which lethal α-emitting radionuclides conjugated to tumor-targeting vectors selectively deliver high
amount of radiation to cancer cells.225Ac, 212Bi, 211At, 213Bi, and 223Ra have been investigated by plenty of clinical trials
and preclinical researches for the treatment of smaller tumor burdens, micro-metastatic disease, and post-surgery residual
disease. In order to send maximum radiation to tumor cells while minimizing toxicity in normal cells, a high affinity
of targeting vectors to cancer tissue is essential. Besides that, the stable and specific complex between chelating
agent and α-emitters was found as a crucial parameter. The present review was planned to highlight recent achievements
about TAT-based targeting vectors and chelating agents and provide further insight for future researches.
Validation of Heart Rate Extracted From Wrist-Based Photoplethysmography in the Perioperative Setting: Prospective Observational Study
Authors: Mestrom Eveline , Deneer Ruben , Bonomi Alberto G , Margarito Jenny , Gelissen Jos , Haakma Reinder , Korsten Hendrikus H M , Scharnhorst Volkher , Bouwman R Arthur 
Published: July 2021

Background
Measurement of heart rate (HR) through an unobtrusive, wrist-worn optical HR monitor (OHRM) could enable earlier recognition of patient deterioration in low acuity settings and enable timely intervention.

Objective
The goal of this study was to assess the agreement between the HR extracted from the OHRM and the gold standard 5-lead electrocardiogram (ECG) connected to a patient monitor during surgery and in the recovery period.

Methods
In patients undergoing surgery requiring anesthesia, the HR reported by the patient monitor’s ECG module was recorded and stored simultaneously with the photopletysmography (PPG) from the OHRM attached to the patient’s wrist. The agreement between the HR reported by the patient’s monitor and the HR extracted from the OHRM’s PPG signal was assessed using Bland-Altman analysis during the surgical and recovery phase.

Results
A total of 271.8 hours of data in 99 patients was recorded simultaneously by the OHRM and patient monitor. The median coverage was 86% (IQR 65%-95%) and did not differ significantly between surgery and recovery (Wilcoxon paired difference test P=.17). Agreement analysis showed the limits of agreement (LoA) of the difference between the OHRM and the ECG HR were within the range of 5 beats per minute (bpm). The mean bias was –0.14 bpm (LoA between –3.08 bpm and 2.79 bpm) and –0.19% (LoA between –5 bpm to 5 bpm) for the PPG- measured HR compared to the ECG-measured HR during surgery; during recovery, it was –0.11 bpm (LoA between –2.79 bpm and 2.59 bpm) and –0.15% (LoA between –3.92% and 3.64%).

Conclusions
This study shows that an OHRM equipped with a PPG sensor can measure HR within the ECG reference standard of –5 bpm to 5 bpm or –10% to 10% in the perioperative setting when the PPG signal is of sufficient quality. This implies that an OHRM can be considered clinically acceptable for HR monitoring in low acuity hospitalized patients.
The Effects of Quartic Term Mathematical Model on The Concentration Profile of Fixed Bed Gas Adsorber
Authors: Putri Ary Mauliva Hada 
Published: July 2021

The need for a reliable mathematical model depicting the process inside a column adsorber has become a requisite in designing an effective gas adsorber. Even though this task can be done by using commercial software, it is still important to get an understanding of how the entire process happens. In this paper, we discuss a new way to approximate the concentration profile inside the porous solids. It is an extension of the work of Liaw et al., who adopted a parabolic (i.e., quadratic) profile, which is a function of pellet radius while retaining the spherical symmetry. We extend their work by adding the quartic term. The inclusion of this new term still preserves the form of linear driving force approximation with some correction to Glueckauf’s parameter (i.e., the effective diffusivity coefficient). The addition of the correction will affect the breakthrough curve so that it affects the saturation time. In the binary system of hydrogen/methane discussed in this study, we found that a negative correction to the diffusivity coefficient will make the saturation happen earlier compared to that of the parabolic case, and vice versa. This study may help us design an efficient gas purifier, in particular when we set out for the regeneration of the adsorbent.Keywords: activated carbon; effective diffusivity coefficient; hydrogen; linear driving force; methane; parabolic profile A B S T R A KKebutuhan model matematis yang dapat menggambarkan proses penyerapan dalam kolom adsorpsi telah menjadi kebutuhan yang tak terelakkan dewasa ini. Walaupun kini telah tersedia berbagai perangkat lunak komersial, namun tidak dapat dipungkiri bahwa memahami bagaimana proses tersebut terjadi tetap menjadi suatu hal yang berguna. Paper ini bertujuan untuk menampilkan cara baru dalam pemodelan konsentrasi adsorbat di dalam adsorben padat berpori. Kami memperluas metode yang dikembangkan Liaw et al. dengan menambahkan suku pangkat empat (kuartik). Penambahan ini akan mengoreksi koefisien difusivitas efektif dari persamaan linear driving force (LDF). Koreksi yang bernilai negatif, misalnya, akan mengurangi nilai koefisien difusivitas tersebut sehingga akan menghambat kemampuan adsorpsi. Hasil perhitungan kami pada sistem biner hidrogen/ metana menunjukkan bahwa suatu koreksi bernilai negatif dapat menyebabkan saturasi berlangsung lebih cepat dari kasus profil parabolik. Begitu pula sebaliknya, koreksi positif akan menambah daya adsorpsi sehingga saturasi dapat diperlambat. Studi ini kami harapkan dapat diterapkan untuk mendesain suatu kolom adsorpsi yang efisien, terutama dalam perencanaan proses regenerasi adsorben.Kata kunci: hidrogen; karbon aktif; koefisien difusivitas efektif; linear driving force; metana; profil parabolik
Características sociodemográficas y clínicas de pacientes con disfunción o con rechazo de injerto renal
Authors: Rodríguez-Medina R.M. , Meza-García C.F. , Díaz-García N.Y. 
Published: July 2021

Introducción: La identificación de las características sociodemográficas y clínicas de los pacientes con disfunción o con rechazo del injerto renal proporcionará información para dirigir la aplicación de intervenciones de enfermería que contribuyan a aumentar la supervivencia del paciente y del injerto renal.
Objetivo: Describir las características sociodemográficas y clínicas de los pacientes con disfunción o con rechazo del injerto renal de un hospital de tercer nivel de León, Guanajuato.
Métodos: Estudio retrospectivo y descriptivo, muestreo por conveniencia. Se identificaron 118 expedientes clínicos de pacientes adultos con diagnóstico de disfunción o con rechazo de injerto renal durante el periodo 2016-2018. Se compararon datos sociodemográficos y clínicos de ambos grupos de pacientes. Se consideró un valor de p< 0.05 para la significancia estadística.
Resultados: El 20.3% de los pacientes ingresaron por disfunción y 79.7% por rechazo de injerto. La edad media de los pacientes fue de 29.9 ± 10.2 años con un rango de edad entre 20 a 84 años. La mayoría de los pacientes fueron hombres con antecedente de trasplante renal de donante fallecido. No se encontraron diferencias en las características clínicas y sociodemográficas de los pacientes con disfunción y los de rechazo de injerto renal.
Conclusiones: La disfunción y el rechazo de injerto renal continúan siendo problemas frecuentes. Aunque no es el caso del presente estudio, se ha encontrado asociación entre algunas características sociodemográficas y la presencia de complicaciones posteriores al trasplante renal.
Narrativa en Enfermería: Una experiencia de cuidado en hemodiálisis
Authors: Ramírez-Girón N. , Landeros-Olvera E. , Cortés-Barragán B. 
Published: July 2021

Introducción: La enfermería es considerada una disciplina científica cuyo fundamento epistemológico está compuesto por conceptos del metaparadigma, patrones y visiones del conocimiento. El análisis de estos elementos a partir de situaciones específicas de la práctica permite la construcción de conocimiento disciplinar, el cual contribuye al mejoramiento de la práctica, dado que se refleja en el quehacer profesional y en la actitud que se asume frente a las situaciones de cuidado.
Objetivo: Analizar una narración de la práctica profesional de una enfermera en sala de hemodiálisis desde elementos epistemológicos propios de la disciplina de enfermería en el marco de la Teoría de Cuidado de Kristen Swanson.
Desarrollo: Se realizó una narrativa en enfermería a partir de una situación vivencial de una enfermera en una sala de hemodiálisis. Se analizaron los conceptos del metaparadigma disciplinar: persona, salud, cuidado y ambiente; los patrones personal, empírico, ético y estético del conocimiento y la visión en enfermería. La Teoría de Cuidados de Kristen Swanson con sus cinco procesos facilitó entender el significado de la situación y de la relación enfermera-paciente.
Conclusión: La narrativa resalta la importancia de continuar el proceso de construcción teórico científico de la disciplina de enfermería, posibilita la reflexión a partir de los elementos epistemológicos y debe ser considerada una metodología disponible para todos los profesionales. A su vez, permite afianzar el conocimiento e ir avanzando en el proceso de teorización para fundamentar con rigor científico el cuidado de la salud humana.
Clima organizacional y satisfacción laboral en trabajadores de la salud
Authors: Del Ángel-Salazar E.M. , Fernández-Acosta C.A. , Santes-Bastián M.C. , Fernández-Sánchez H. , Zepeta-Hernández D. 
Published: July 2021

Introducción: Los trabajadores de la salud son personas que prestan apoyo a la gestión clínica-asistencial y proveen los servicios con condiciones de trabajo que influyen en su salud y vida.
Objetivo: Analizar la relación entre el clima organizacional y la satisfacción laboral del personal que trabaja en una institución de salud.
Métodos: Se realizó un estudio transversal analítico de correlación en una unidad de medicina familiar. El tamaño de la muestra fue de 182 trabajadores, quienes contestaron la Escala de Clima Organizacional integrada por las dimensiones de relaciones interpersonales, estilo de dirección, sentido de pertinencia, retribución, disponibilidad de recursos, claridad y coherencia en la dirección, estabilidad y valores colectivos; y el Cuestionario de Satisfacción Laboral integrado por los factores de satisfacción relacionado con la supervisión, el ambiente físico, las prestaciones recibidas, la participación y la satisfacción laboral intrínseca. Se obtuvo el consentimiento informado de los participantes.
Resultados: La mayoría presentó clima organizacional por mejorar (56%) y 40.7% registró como satisfactorio la variable satisfacción laboral a muy satisfactorio (46.2%). Se encontró una correlación significativa moderada entre el clima organizacional y la satisfacción laboral (rs = 0.205; p = 0.05).
Discusión: La correlación fue semejante a otros estudios, indicando que a mayor percepción del clima organizacional, mayor será la satisfacción laboral de los trabajadores.
Conclusiones: Se identificó una correlación positiva entre la percepción del clima organizacional y satisfacción laboral en trabajadores de la salud.
Assisted suicide: Perception of nursing students about professional performance on this topic
Authors: Timóteo-Costa D. , Marinalva-de Barros V. , Rodrigues-da Silva D.M. , Lima-Cavalcanti I.D. , De Aquino J.M. , Domingues-do Nascimento C.A. 
Published: July 2021

Introduction: Assisted suicide is considered an action in which a patient, wishes to terminate his/her life due to the pain and suffering caused by a disease and requests the necessary help from the healthcare professionals. The right to decide about ending one’s own life and the impact attributed to the experienced suffering are the main questions regarding assisted suicide.
Objective: Characterize the perceptions of nursing students about professional performance in the face of assisted suicide.
Methods: The research comprised a descriptive analysis with a qualitative approach, based on the application of semi-structured interviews on nursing students enrolled in the curricular 9th period, during 2014, in the city of Recife-PE, Brazil. The sample consisted of 19 students. The data, were analyzed and categorized using the Collective Subject Discourse (CSD) method.
Results and Discussion: The obtained data suggest that students consider assisted suicide as a way of preserving dignity in the face of procedures that will make the death an inevitably painful process. Indicate that euthanasia and assisted suicide should remain illegal, and they would not get involved professionally. But others assured their willingness to participate because they would be satisfying the patient's wishes, however, for its legalization it is necessary to create principles that would guide the execution of these procedures.
Conclusion: The students consider, that the professional can eliminate real possibilities of treatment and recovery of the patient by accepting his request for suicide. However, some students are in favor of this procedure, arguing that the patient is free to conduct his own life.
Una guía para la estimación de la tensión interfasiales y el espesor de la interface de un sistema agua/hidrocarburo usando el programa gromacs-4.5.4
Authors: Parra Figueredo José Gregorio , Iza Peter , Perozo Elizabeth 
Published: July 2021

<p class="western" lang="es-VE" align="justify">La dinámica molecular es una herramienta muy útil para estudiar los fenómenos interfaciales. Aquí se presenta un procedimiento usando el programa GROMACS-4.5.4, el cual es empleado en el laboratorio de fisicoquímica, para estimar la tensión interfacial y el espesor de película interfacial del sistema agua/n-octano con el modelo de Kirkwood-Buff y la teoría onda-capilar. En la simulación, se utilizan los tensores de presión y la tensión interfacial más aceptable fue obtenida combinando los modelos TIP3P y GROMOS53A6 para el agua y n-octano. </p>
SOSIALISASI PENGIMPLEMENTASIAN PEDOMAN AKUNTANSI PESANTREN BERBASIS DIGITAL PADA PESANTREN DI INDONESIA
Authors: Sukmadilaga Citra 
Published: July 2021

Tujuan dilakukannya pelatihan akuntansi Pesantren membantu mewujudkan pesantren yang transparan, akuntabel, partisipatif, tertib dan disiplin keuangan serta menambah pengetahuan pengelola pesantren betapa pentingnya peranan akuntansi pesantren dalam rangka akuntabilitas public. Metode penelitian ini dilakukan dengan Focus Group Discussion yang dihadiri oleh 38 orang pengelola keuangan pesantren yang tersebar di wilayah Kalimantan, Jawa Barat, Jawa Tengah. Hasil yang diperoleh adalah akuntansi pesantren masih sangat sulit untuk diimplementasikan karena pesantren pada umumnya bersifat tertutup, terpusat dan kekeluargaan. Lebih-lebih jika menyangkut persoalan keuangan, hanya kiyai dan keluarganyalah yang boleh mengetahuinya. Selain itu, banyak pesantren yang tidak memisahkan antara harta kekayaan pesantren dengan individu, walaupun disadari bahwa pembiayaan pesantren justru lebih banyak bersumber dari kekayaan individu sebab sumber-sumberlain penopang pesantren kurang memadai. Terdapat beberapa faktor yang berperan dalam kesuksesan implementasi akuntansi pesantren yaitu manajemen sebagai faktor Upaya, organisasi sebagai faktor Sarana, dan administrasi sebagai faktor Karsa. Ketiga faktor ini memberi arah dan perpaduan dalam merumuskan, mengendalikan penyelenggaraan, mengawasi serta menilai pelaksanaan kebijakan-kebijakan dalam usaha menyelenggarakan akuntansi yang sesuai dengan tujuan Pondok Pesantren masing-masing.
Peel Off Gel Mask containing Green Tea Leaf Extract (Camellia sinesis L) with Antioxidant Activity
Authors: Chaerunisaa Anis Yohana , Surachman Emma , Khuzaimah Zila 
Published: July 2021

Peel off mask has been very popular and preferred due to its ease in application. Gel base has been preferred for its cold and moist sensation during application. When herbal ingredients such as extract is introduced into gel formulation, the stability then will become an issue. The aim of the study was to formulate the peel-off mask gels containing green tea leaves extract (Camellia sinensis L.) which effective, stable, and safe to be used. The antioxidant study was conducted by using Diphenylhydrazylpicryl (DPPH) method. The peel-off mask gel formula were Hidroxypropyl Methylcelulosa (HPMC) as gel base at 0.5% concentration and plasticizer Polyvinyl Alcohol (PVA) at concentration of 12%. Evaluation of peel-off mask gel included observation on pH, viscosity, dispersing power, and drying time during the 90 days of storage at room temperature. The IC50 values of the green tea (Camellia sinensis L.) extract was 5.511 ppm. The concentration of green tea leaves extract in the preparation were 1x IC50 (F1); 2x IC50 (F2) and 3x IC50 (F3). The result showed that all preparations were stable in the aspect of consistency, color, and odor. Viscosity, drying time and dispersing power remained unchanged after 90 days of storage. The pH value changed, but still in the range of acceptable pH of topical preparations. The results of antioxidant activity study showed that formula F3 (peel-off mask gels with 3 x IC50 of green tea extracts) had the highest antioxidant activity.Keywords: antioxidant, Camellia sinensis L., peel off gel masks, green tea
Pharmaceutical Industrial Waste Regulation in Five Countries in Asia
Authors: Azzahra Luthfia , Saptarini Nyi Mekar 
Published: July 2021

The pharmaceutical industry produces a various toxic wastes. Generated waste increases the risk of environmental and ecosystem pollution. It is necessary to have proper waste management to prevent waste pollution to the environment. In 1999, WHO published “Guidelines for the Safe Disposal of Unwanted Pharmaceuticals in and after Emergencies”, that contain treatments and safe disposal method, which is appropriate for any country. Many countries had developed and published regulations and guidelines on waste management. This article aimed to review the handling of pharmaceutical industrial waste in five countries in Asia. This review included studies from ProQuest, Crossref, and Google Scholar. The pharmaceutical industries in Indonesia, India, Japan, Thailand, and China has their own state regulations in order to protect the environment. They also had implemented pharmaceutical industrial waste management following their regulation and guidelines. The method used to treat the waste is similar with WHO guideline. Some factors affecting the country regulations are the insufficient of land and waste management facilities, lack of awareness, low penalties, limited infrastructures, lack of waste testing facilities. The challenge in the future to handle pharmaceutical waste are increasing waste volume, decreasing land for waste management, sewer methods may contaminate water, possible air pollution due to incineration, so it is necessary to have more advanced methods in waste management that are safe for the environment and humans.Keywordz: Industry, Pharmaceutical, Waste Regulation, Asia
PENGARUH LIKUIDITAS (QUICK RATIO) DAN PERPUTARAN MODAL KERJA TERHADAP RETURN ON ASSET (Studi Kasus pada Perusahaan Sub Sektor Logam yang Terdaftar di Bursa Efek Indonesia Periode 2011-2015)
Authors: Ning Tias Utami Prihati , Purwanti Arni , Surtikanti Surtikanti 
Published: July 2021

Perolehan keuntungan maksimal atau laba yang sebesar-besarnya adalah salah satu tujuan didirikannya suatu perusahaan. Pada setiap kegiatan perusahaan ada unsur-unsur yang menimbulkan sebab akibat naik atau turunnya kemampuan perusahaan dalam menghasilkan laba, dan hal tersebut dapat dilihat dari beberapa faktor yang diindikasikan berpengaruh dalam naik atau turunnya kemampuan perusahaan dalam menghasilkan laba seperti, Likuiditas (Quick Ratio) dan Perputaran Modal Kerja. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh Likuiditas (Quick Ratio) dan Perputaran Modal Kerja terhadap Return on Asset pada Perusahaan Sub Sektor Logam Yang Terdaftar Di Bursa Efek Indonesia. Pengujian pada penelitian ini dilakukan dengan menggunakan bantuan software SPSS Versi 16.0. Metode analisis yang digunakan adalah analisis deskriptif dan verifikatif dengan pendekatan kuantitatif. Populasi dalam penelitian ini sebanyak 7 perusahaan Sub Sektor Logam yang terdaftar di Bursa Efek Indonesia periode penelitian 2011-2015. Sampel menggunakan metode purposive sampling dengan kriteria-kriteria tertentu. Metode analisis yang digunakan adalah analisis regresi linier berganda. Hasil pengujian hipotesis dalam penelitian ini menunjukkan bahwa (1) Likuiditas (Quick Ratio) memiliki pengaruh negatif dan signifikan pada Return on Asset (2) Perputaran Modal Kerja memiliki pengaruh positif dan signifikan pada Return on Asset di perusahaan manufaktur sub sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia periode penelitian 2011-2015. Obtaining maximum profit is one of the purposes of the establishment of a company. In every company actions or activities there are elements which give the cause and effect of the company in generating profits, and this can be seen from some of the factors indicated in rise or decline in the company's ability in producing such profits, liquidity (Quick Ratio) and Working Capital Turnover. The purpose of this research is to acknowledge the influence of liquidity (Quick Ratio) and Working Capital Turnover against Return on Asset on metal sub sector companies enlisted in Indonesia Stock Exchange. In this study, the test of mediation variables is also done by using SPSS v. 16.0. The methods used were descriptive and verificative analysis. The population in this research are 7 metal sub sectors companies enlisted in Indonesia stock exchange period 2011-2015. Sampling method was using purposive sampling with specific criteria. Analysis method was using multi-linear regression analysis. The results of hypothesis testing in this study suggest that (1) Liquidity (Quick Ratio) has negative and significant influence on Return on Asset (2) Turnover of working capital has positive and significant effect on Return on Asset in the metal manufacturing sub sector company enlisted on the Indonesia Stock Exchange period 2011-2015.