bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases
Authors: Cardenas-Rodriguez Magdalena , Austin-Tse Christina , Bergboer Judith G. M. , Molinari Elisa , Sugano Yuya , Bachmann-Gagescu Ruxandra , Sayer John A. , Drummond Iain A. 
Published: June 2021

ABSTRACT
Mutations in CEP290 (also known as NPHP6), a large multidomain coiled coil protein, are associated with multiple cilia-associated syndromes. Over 130 CEP290 mutations have been linked to a wide spectrum of human ciliopathies, raising the question of how mutations in a single gene cause different disease syndromes. In zebrafish, the expressivity of cep290 deficiencies were linked to the type of genetic ablation: acute cep290 morpholino knockdown caused severe cilia-related phenotypes, whereas deficiencies in a CRISPR/Cas9 genetic mutant were restricted to photoreceptor defects. Here, we show that milder phenotypes in genetic mutants were associated with the upregulation of genes encoding the cilia-associated small GTPases arl3, arl13b and unc119b. Upregulation of UNC119b was also observed in urine-derived renal epithelial cells from human Joubert syndrome CEP290 patients. Ectopic expression of arl3, arl13b and unc119b in cep290 morphant zebrafish embryos rescued Kupffer's vesicle cilia and partially rescued photoreceptor outer segment defects. The results suggest that genetic compensation by upregulation of genes involved in a common subcellular process, lipidated protein trafficking to cilia, may be a conserved mechanism contributing to genotype-phenotype variations observed in CEP290 deficiencies.
This article has an associated First Person interview with the first author of the paper.
Die Beth-El-Steine von Riehen
Authors: Moosbrugger-Leu Rudolf 
Published: June 2021

Hinter der Riehener Dorfkirche wurde 1973 ein kleiner mittelalterlicher Friedhof entdeckt. Die Gräber waren beigabenlos. In den Grabgruben konnten keine Spuren von Särgen oder hölzernen Ausschachtungen festgestellt werden. Die Toten wurden wahrscheinlich in einem Leichentuch beigesetzt. In einigen Gruben fiel ein Stein auf, der unmittelbar hinter dem Schädelscheitel anstand. Diese Steine waren in der Erde verborgen und hatten keine erkennbare konstruktive Funktion.
Der Autor bringt sie in Beziehung zu einer Stelle im Alten Testament (1. Moses, 28, 10-19: Jakob weiht nach seinem Traum von der Himmelsleiter den Stein, den er als Kopfkissen benutzt hat, indem er Öl darüber giesst und nennt den Ort Beth-El, Haus Gottes). Der Akt der Steinsetzung im Grab wird als Glaubensbekenntnis der damaligen Bevölkerung gedeutet.
Interpretation und Synthese der Bauforschungen zwischen 1981 und 2000 am Rollerhof, Münsterplatz 20
Authors: Ritzmann Hans 
Published: June 2021

Im Lauf der letzten 20 Jahre wurden im Rollerhof verschiedene Teilbereiche baugeschichtlich untersucht.
Bereits 1981 wurde die spätromanische Giebelmauer des Rollerhofs im Erdgeschoss von der Durchfahrt her untersucht. Die in schönen Lagen erbaute Mauer, die zwei nachträglich eingefügte Rundbogenfenster aus Stuckmörtel aufweist, wurde teilweise sichtbar belassen. Dieses Mauerstück gehört zu einem der ursprünglich zwei Kernbauten, die später zum heutigen Rollerhof zusammengefasst wurden.
Die Entwicklung des Rollerhofs seit dem Spätmittelalter war 1986 an der Hoffassade ablesbar. Die prächtige Aufzugsgaupe ist inschriftlich ins Jahr 1583 datiert.
Im heute durch die Laubengänge mit ihren Balustern barock geprägten Hof konnte an den Mauern auch die Entwicklung der Flügelbauten erkannt werden. Das älteste Element im Hof ist die hintere Hofbegrenzungsmauer, deren Substanz wohl bis in die 2. Hälfte des 13. Jahrhunderts zurückreicht.
Augustinergasse 17
Authors: Jaggi Bernard 
Published: June 2021

Die baugeschichtlichen Untersuchungen der Liegenschaft erbrachten den Nachweis einer mittelalterlichen Bebauung der Parzelle mit Steinbauten, welche bereits als verbindliche Vorgabe für die nachfolgenden Neubauten nach dem Erdbeben von 1356 wirksam war.
An der Augustinergasse stand in mittelalterlicher Zeit ein Steinbau unbekannter Grösse, welcher mit 6 m Bautiefe die Parzelle belegte. Am anderen Ende an der Rheinhalde bestand gleichzeitig ein Mauergeviert mit terrassenähnlicher Ausprägung, welches den Unterbau für das spätere Hinterhaus bildete.
Frühmittelalterliche Grabfunde im Umkreis des Antikenmuseums in Basel
Authors: Helmig Guido , Ihrig Barbara , Meyer Liselotte , Nicca Martina , Rast Antoinette , Schillinger Franziska 
Published: June 2021

Im vorliegenden Fall sind zwei vergleichsweise reich ausgestattete frühmittelalterliche Gräber zum Schluss der grossflächigen Ausgrabungen im Hof des Antikenmuseums quasi im letzten, kaum 2,5 Meter breiten Erdstreifen entdeckt worden.
Die beiden Bestattungen waren nahezu intakt. Beide waren reich mit Beigaben respektive Trachtbestandteilen ausgestattet. Anhand der Begleitfunde konnten die beiden Toten einer nicht romanisierten, germanischen Bevölkerungsgruppe - wohl der damals rechtsrheinisch ansässigen Alamannen - zugeordnet werden. Schmuck und Vierfibeltracht der Frau, aber auch die Waffe sowie ein cloisonnierter Taschenbeschlag aus dem Männergrab weisen die Bestatteten als Angehörige einer gehobenen Bevölkerungsschicht des ausgehenden 5. bzw. frühen 6. Jahrhunderts aus.
Vorbericht über die Grabungen 2002 in der Schnabelgasse 6
Authors: Rodel Sylvia 
Published: June 2021

Bei den archäologischen Untersuchungen im Hinterhof der Liegenschaft Schnabelgasse 6 kamen auf kleinster Fläche zahlreiche Befunde zum Vorschein - Zeugnisse einer regen Bautätigkeit, die im Hochmittelalter einsetzte und bis ins 20. Jahrhundert hinein fortdauerte.
Als Überraschung darf die Entdeckung einer Latrine aus dem 12. Jahrhundert bezeichnet werden. Sie gehört, zusammen mit hochmittelalterlichen Mauerteilen des Vorderhauses, zur ältesten nachweisbaren Überbauung auf der Parzelle.
Orthopaedic provider perceptions of virtual care
Authors: Yedulla Nikhil R. , Montgomery Zachary A. , Koolmees Dylan S. , Battista Eric B. , Day Charles S. 
Published: June 2021

AimsThe purpose of our study was to determine which groups of orthopaedic providers favour virtual care, and analyze overall orthopaedic provider perceptions of virtual care. We hypothesize that providers with less clinical experience will favour virtual care, and that orthopaedic providers overall will show increased preference for virtual care during the COVID-19 pandemic and decreased preference during non-pandemic circumstances.MethodsAn orthopaedic research consortium at an academic medical system developed a survey examining provider perspectives regarding orthopaedic virtual care. Survey items were scored on a 1 to 5 Likert scale (1 = “strongly disagree”, 5 = “strongly agree”) and compared using nonparametric Mann-Whitney U test.ResultsProviders with less experience were more likely to recommend virtual care for follow-up visits (3.61 on the Likert scale (SD 0.95) vs 2.90 (SD 1.23); p = 0.006) and feel that virtual care was essential to patient wellbeing (3.98 (SD 0.95) vs 3.00 (SD 1.16); p < 0.001) during the pandemic. Less experienced providers also viewed virtual visits as providing a similar level of care as in-person visits (2.41 (SD 1.02) vs 1.76 (SD 0.87); p = 0.006) and more time-efficient than in-person visits (3.07 (SD 1.19) vs 2.34 (SD 1.14); p = 0.012) in non-pandemic circumstances. During the pandemic, most providers viewed virtual care as effective in providing essential care (83.6%, n = 51) and wanted to schedule patients for virtual care follow-up (82.2%, n = 50); only 10.9% (n = 8) of providers preferred virtual visits in non-pandemic circumstances.ConclusionOrthopaedic providers with less clinical experience seem to favourably view virtual care both during the pandemic and under non-pandemic circumstances. Providers in general appear to view virtual care positively during the pandemic but are less accommodating towards it in non-pandemic circumstances. Cite this article: Bone Jt Open 2021;2(6):405–410.
Human immune response against salivary antigens of Simulium damnosum s.l.: A new epidemiological marker for exposure to blackfly bites in onchocerciasis endemic areas
Authors: Willen Laura , Basáñez Maria-Gloria , Dvorak Vit , Veriegh Francis B. D. , Aboagye Frank T. , Idun Bright , Osman Maha Elhadi , Osei-Atweneboana Mike Y. , Courtenay Orin , Volf Petr 
Published: June 2021

Background
Simulium damnosum sensu lato (s.l.) blackflies transmit Onchocerca volvulus, a filarial nematode that causes human onchocerciasis. Human landing catches (HLCs) is currently the sole method used to estimate blackfly biting rates but is labour-intensive and questionable on ethical grounds. A potential alternative is to measure host antibodies to vector saliva deposited during bloodfeeding. In this study, immunoassays to quantify human antibody responses to S. damnosum s.l. saliva were developed, and the salivary proteome of S. damnosum s.l. was investigated.

Methodology/Principal findings
Blood samples from people living in onchocerciasis-endemic areas in Ghana were collected during the wet season; samples from people living in Accra, a blackfly-free area, were considered negative controls and compared to samples from blackfly-free locations in Sudan. Blackflies were collected by HLCs and dissected to extract their salivary glands. An ELISA measuring anti-S. damnosum s.l. salivary IgG and IgM was optimized and used to quantify the humoral immune response of 958 individuals. Both immunoassays differentiated negative controls from endemic participants. Salivary proteins were separated by gel-electrophoresis, and antigenic proteins visualized by immunoblot. Liquid chromatography mass spectrometry (LC–MS/MS) was performed to characterize the proteome of S. damnosum s.l. salivary glands. Several antigenic proteins were recognized, with the major ones located around 15 and 40 kDa. LC–MS/MS identified the presence of antigen 5-related protein, apyrase/nucleotidase, and hyaluronidase.

Conclusions/Significance
This study validated for the first time human immunoassays that quantify humoral immune responses as potential markers of exposure to blackfly bites. These assays have the potential to facilitate understanding patterns of exposure as well as evaluating the impact of vector control on biting rates. Future studies need to investigate seasonal fluctuations of these antibody responses, potential cross-reactions with other bloodsucking arthropods, and thoroughly identify the most immunogenic proteins.
Anni Albers, Ann Coxon, Briony Fer and Maria Müller-Schareck (eds) (2018)
Authors: Bothe Lauren 
Published: June 2021

Review of: Anni Albers, Ann Coxon, Briony Fer and Maria Müller-Schareck (eds) (2018)
London: Yale University Press in association with Tate Publishing, 192 pp., 190 colour illus.,
ISBN 978-0-30023-725-2, h/bk, £38.27/$50.00
Sfery oraz mechanizmy generowania zjawisk i procesów politycznych
Authors: Blok Zbigniew 
Published: June 2021

Autor zakłada, iż skoro politologia nie legitymuje się własną tożsamością przedmiotową, jak i metodologiczną, to badacze są każdorazowo zmuszeni do zdefiniowania przedmiotu swych badań oraz zadeklarowania przyjętych założeń metodologicznych. Pole polityki nie jest polem jednorodnym, co oznacza, iż wypełnione jest różnorodnymi bytami ontologicznymi. Polityka może zatem przyjąć postać metody działania, swoistego instrumentu, może mieć wymiar realny bądź mityczny, może być obiektem dającym się obserwować, jak i nie poddającym się temu procesowi. W artykule poddano analizie najważniejsze typy aktywności społecznych, które decydują o warunkach egzystencji całych społeczeństw. Starano się też wskazać na sfery i mechanizmy, które nadają tym zjawiskom i procesom charakteru politycznego. Według autora „polityczności” należy poszukiwać w relacjach, jakie zachodzą pomiędzy różnymi typami aktywności społecznej. Przyjęcie czterech typów aktywności oznacza, że możemy wyróżnić 4 płaszczyzny kreowania zjawisk i procesów politycznych:
– pole pierwszego stopnia, które stwarza każdy typ aktywności decydującej o egzystencji społeczeństwa;
– pole drugiego stopnia, które tworzą przekroje dwupłaszczyznowe, np. społeczeństwo gospodarujące i państwowe, czy społeczeństwo państwowe i ideowe itd.;
– pole trzeciego stopnia, wyznaczone przez przekroje trzech rodzajów społeczeństw, np. gospodarującego, państwowego i ideowego;
– i wreszcie pole „jądra polityki”, które jest przekrojem czterech typów aktywności i stąd jego najważniejsza rola w kreowaniu zjawisk i procesów politycznych oraz w wyjaśnianiu polityki.
Przeciwstawną pozycję względem „jądra” zajmują „marginalia polityki”, które w sprzyjających okolicznościach, w odpowiednim miejscu i czasie mogą nabrać politycznego znaczenia i mogą wykreować odrębne pole.
Multilingualism and Language Contact in the Cely Letters
Authors: Conde-Silvestre J. Camilo 
Published: June 2021

AbstractThe Cely Letters is a well-known collection of correspondence exchanged by members of this London family of wool merchants and their associates between 1472 and 1488. A substantial part of the corpus was written and received by factors based in Calais, which had been an English outpost in France since 1346 and was strategically connected to the wool marts of the Low Countries. The great majority of the letters are monolingual English texts, thus attesting to the widespread use of the vernacular in personal correspondence by the late fifteenth century. Nevertheless, behind the monolingual English surface, traces of multilingualism are revealed. In this paper, I intend to analyse this issue with a twofold purpose. In the first place, attention will be paid to the multilingual background of the letters, considering both the persistent use of French in late medieval England and the specificity of the business transactions carried out at Calais and the marts, where language contact must have been the norm. In the second place, different textual reflections of such contact in the letters are examined and classified, both as regards the generic conventions of letter writing and as part of the multilingual business context where they were produced and received.
The Old English Glosses in Cambridge, Trinity College, B.10.5 + London, British Library, Cotton Vitellius C.viii: A Reappraisal with Some New Glosses
Authors: O’Neill Patrick P. 
Published: June 2021

Abstract
A reassessment of the Old English glosses in Cambridge, Trinity College, B.10.5, as well as a presentation of three new glosses found in another fragment of the same manuscript, now London, British Library, Cotton Vitellius C.viii, with special focus on their language and function.
Tensions in Piketty’s Participatory Socialism: Reconciling Justice and Democracy
Authors: Lippert-Rasmussen Kasper , Albertsen Andreas 
Published: June 2021

Abstract
In the final parts of Piketty’s Capital and Ideology, he presents his vision for a just and more equal society. This vision marks an alternative to contemporary societies, and differs radically both from the planned Soviet economies and from social democratic welfare states. In his sketch of this vision, Piketty provides a principled account of how such a society would look and how it would modify the current status of private property through co-managed enterprises and the creation of temporary ownership models. He also sets out two principles for when inequalities are just. The first principle permits inequalities that are beneficial to the worst-off, while the second permits inequalities that reflect differences in people’s choices and ambitions. This article identifies a tension between Piketty’s two inequality-permitting principles. It also argues that the procedural limits on how decisions are made within the enterprises of participatory socialism might create inequalities not permitted by the guiding distributive principles of participatory socialism. This tension points to the need for either further changes in firm structure and ownership, an even more progressive taxation scheme, or an egalitarian ethos reflected in citizens’ choices in their everyday lives under participatory socialism.
More Lessons to Learn: Thomas Piketty’s Capital and Ideology and Alternative Archives of Social Experience
Authors: Langenohl Andreas 
Published: June 2021

Abstract
Thomas Piketty’s Capital and Ideology has been written with the intention to offer lessons from the historical trajectory of economic redistribution in societies the world over. Thereby, the book suggests learning from the political-economic history of ‘social-democratic’ policies and societal arrangements. While the data presented speak to the plausibility of looking at social democracy, as understood by Piketty, as an archive for learning about the effects of redistribution mechanisms, I argue that the book, or future interventions might profit from integrating alternative archives. On the one hand, its current line of argumentation tends to underestimate the significance of power relations in the international political economy that continued after formal decolonization, and thus form the flip side of social democracy’s success in Europe and North America. On the other hand, the role of the polity might be imagined in a different and more empowering way, not just-as in Piketty-as an elite-liberal democratic governance institution; for instance, it would be interesting to explore the archive of the French solidaristes movement more deeply than Piketty does, as well as much more recent interventions in economic anthropology that deal with ‘economic citizenship’ in the Global South.
About Capital, Socialism and Ideology
Authors: Piketty Thomas 
Published: June 2021

Abstract
In this article, I attempt to briefly clarify a number of issues regarding what I have tried to achieve in my book Capital and Ideology. I also comment on the many limitations behind such a project,whose main objective is to stimulate further research on the global history of inequality regimes, at the intersection of economic, social and political history. Lastly, I address some of the many stimulating points raised in the reviews, particularly regarding the nature of participatory socialism and its incompleteness.
The Role of Culture in Evolutionary Theories of Human Cooperation
Authors: Qirko Hector 
Published: June 2021

Abstract
Evolutionarily-minded scholars working on the most puzzling aspects of human cooperation-one-shot, anonymous interactions among non-kin where reputational information is not available-can be roughly divided into two camps. In the first, researchers argue for the existence of evolved capacities for genuinely altruistic human cooperation, and in their models emphasize the role of intergroup competition and selection, as well as group norms and markers of membership that reduce intragroup variability. Researchers in the second camp explain cooperation in terms of individual-level decision-making facilitated by evolved cognitive mechanisms associated with well-established self- and kin-maximization models, as well as by ‘misfires’ that may result from these mechanisms interacting with novel environments. This essay argues that the manner in which culture provides information that de-anonymizes intragroup strangers suggests that neither evolved capacities for genuine altruism nor widespread misfires are necessary to account for anonymous, one-shot cooperation.
Normative Guidance, Evaluative Guidance, and Skill
Authors: Railton Peter 
Published: June 2021

Abstract
At least since Aristotle, practical skill has been thought to be a possible model for individual ethical development and action. Jonathan Birch’s ambitious proposal is that practical skill and tool-use might also have played a central role in the historical emergence and evolution of our very capacity for normative guidance. Birch argues that human acquisition of motor skill, for example in making and using tools, involves formation of an internal standard of correct performance, which serves as a basis for normative guidance in skilled thought and action, and in the social transfer of skills. I suggest that evaluativemodeling, guidance, and learning play a more basic role in motor skill than standards of correctness as such-indeed, such standards can provide effective normative guidance thanks to being embedded within evaluative modeling and guidance. This picture better fits the evidence Birch cites of the flexibility, adaptability, and creativity of skills, and can support a generalized version of Birch’s ‘skill hypothesis’.
Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?
Authors: Stefanowicz-Rutkowska Magdalena Maria , Matuszewski Wojciech , Gontarz-Nowak Katarzyna , Bandurska-Stankiewicz Elżbieta Maria 
Published: June 2021

Abstract
Autoimmune thyroid disease (AITD) is more common among diabetes mellitus (DM) patients and may impact its microvascular complications. The present study aimed to assess the relationship between AITD and the prevalence of diabetic kidney disease (DKD) in patients with diabetes mellitus type 1 (DM1). Anthropometric parameters, parameters of metabolic control of DM, thyreometabolic status, and the UACR were assessed. DKD was diagnosed if patients’ UACR level was ≥30 mg/g or eGFR level was <60 mL/min. This study involved 144 patients with DM1 aged 36.2 ± 11.7 years: 49 men and 95 women. Significant differences in creatinine, eGFR, and UACR levels were found in patients with DKD. fT3 concentration was significantly lower among DKD patients. A significantly higher probability of DKD was found in DM1 patients with lower fT3 levels. Patients with DM1 and AITD had significantly lower creatinine levels than the control group. However, the study did not show any significant relationship between AITD and the occurrence of DKD in patients with DM1. Significantly lower fT3 concentrations in DKD patients may be caused by metabolic disorders in the course of DKD and require further cohort studies in a larger population of patients with DM1 and AITD.
Intimidad, identidad y máscara
Authors: González Requena Jesús 
Published: June 2021

Este artículo versará sobre el ser de la máscara, que será desplegado por la vía de una fenomenología de las formas del vestirse y del disfrazarse, en las que comparte un común territorio con el velo, la ropa y el disfraz, tanto como sus contrapartidas; el rostro, el cuerpo y sus pasiones.
Se analizará a continuación la dialéctica entre la máscara-máscara —aquella que se declara tal— y el rostro-máscara, la máscara que se oculta a sí misma para proclamarse identidad.
Finalmente, se reflexionará sobre la relación esencial entre la máscara y la intimidad, se mostrará cómo la primera es la condición material de posibilidad de la segunda, y se concluirá con una referencia al acto del amor, como aquel en el que se ofrece al otro el acceso a una intimidad que solo la máscara hace posible.