bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy-specific Herbal Group Detection from Traditional Chinese Medicine Prescriptions via Hierarchical Attentive Neural Network Model
Authors: Chen Li , Liu Xinglong , Zhang Siyuan , Yi Hong , Lu Yongmei , Yao Pan 
Published: January 2021

Abstract
Background: Mining massive prescriptions in Traditional Chinese Medicine (TCM) accumulated in the lengthy period of several thousand years to discover essential herbal groups for distinct eﬃcacies is of signiﬁcance for TCM modernization, thus starting to draw attentions recently. However, most existing methods for the task treat herbs with diﬀerent surface forms orthogonally and determine eﬃcacy-speciﬁc herbal groups based on the raw frequencies an herbal group occur in a collection of prescriptions. Such methods entirely overlook the fact that prescriptions in TCM are formed empirically by diﬀerent people at diﬀerent historical stages, and thus full of herbs with diﬀerent surface forms expressing the same material, or even noisy and redundant herbs.Methods: We propose a two-stage approach for eﬃcacy-speciﬁc herbal group detection from prescriptions in TCM. For the ﬁrst stage we devise a hierarchical attentive neural network model to capture essential herbs in a prescription for its eﬃcacy, where herbs are encoded with dense real-valued vectors learned automatically to identify their diﬀerences on the semantical level. For the second stage, frequent patterns are mined to discover essential herbal groups for an eﬃcacy from distilled prescriptions obtained in the ﬁrst stage.Results: We verify the eﬀectiveness of our proposed approach from two aspects, the ﬁrst one is the ability of the hierarchical attentive neural network model to distill a prescription, and the second one is the accuracy in discovering eﬃcacy-speciﬁc herbal groups.Conclusion: The experimental results demonstrate that the hierarchical attentive neural network model is capable to capture herbs in a prescription essential to its eﬃcacy, and the distilled prescriptions signiﬁcantly could improve the performance of eﬃcacy-speciﬁc herbal group detection.
Does admission prevalence change after reconfiguration of inpatient services? An interrupted time series analysis of the impact of reconfiguration in five centres
Authors: Martin Joanne , Raja Edwin Amalraj , Turner Steve 
Published: January 2021

Abstract
Background. Service reconfiguration of inpatient services in a hospital includes complete and partial closure of all emergency inpatient facilities. The “natural experiment” of service reconfiguration may give insight into drivers for emergency admissions to hospital. This study addressed the question does the prevalence of emergency admission to hospital for children change after reconfiguration of inpatient services?Methods. There were five service reconfigurations in Scottish hospitals between 2004 and 2018 where emergency admissions to one “reconfigured” hospital were halted (permanently or temporarily) and directed to a second “adjacent” hospital. The number of emergency admissions (standardised to /1000 children in the regional population) per month to the “reconfigured” and “adjacent” hospitals was obtained for five years prior to reconfiguration and up to five years afterwards. An interrupted time series analysis considered the association between reconfiguration and admissions across pairs comprised of “reconfigured” and “adjacent” hospitals, with adjustment for seasonality and an overall rising trend in admissions.Results. Of the five episodes of reconfiguration, two were immediate closure, two involved closure only to overnight admissions and one with overnight closure for a period and then closure. In “reconfigured” hospitals there was an average fall of 117 admissions/month [95% CI 78, 156] in the year after reconfiguration compared to the year before, and in “adjacent” hospitals admissions rose by 82/month [32, 131]. Across paired reconfigured and adjacent hospitals, in the months post reconfiguration, the overall number of admissions to one hospital pair slowed, in another pair admissions accelerated, and admission prevalence was unchanged in three pairs. After reconfiguration in one hospital, there was a rise in admissions to a third hospital which was closer than the named “adjacent” hospital. Conclusions. There are diverse outcomes for the number of emergency admissions post reconfiguration of inpatient facilities. Factors including resources placed in the community after local reconfiguration, distance to the “adjacent” hospital and local deprivation may be important drivers for admission pathways after reconfiguration. Policy makers considering reconfiguration might consider a number of factors which may be important determinants of admissions post reconfiguration.
Enriching the nutritive value of Marigold (Tagetes erecta L) crop residues as a ruminant​ feed by lactic acid​ during ensilage
Authors: Hou Zhijiang , Liu Jianyong , Cai Ming , Liu Yanpei , Mu Lan , Gao Yuee , Wanapat Metha , Huang Bizhi 
Published: January 2021

Abstract
Background: Marigold (Tagetes erecta L) accounts for over half of the world's loose flower production, and marigold crop residue (MCR) are abundantly available and should be used as a forage. In this study, MCR from the last commercial flower pickings was ensilaged with lactic acid bacteria (LAB) and the shift in their volatile organic compounds (VOCs) profiles was monitored. Samples were collected at 6 different times during ensilage (3, 6, 9, 12, 15, 30 days) to determine and quantify the VOCs changes using a solid-phase microextraction (SPME) technique and gas chromatography – mass spectrometry (GC-MS). Results: After 30 days, the caryophyllene and piperitone, which account for 14.7% and 12.1% of total VOCs, decreased by 32.9% and 9.6% respectively, alcohols increased from 2.8% to 8.1%, and the acetic acid content increased by 560%. Conclusion: We have confirmed LAB can degrade the content of terpenes and enhance the content of alcohols and acids in MCR, which was for the first time on terpene degradation in fodder by ensilage. These results have shed light on our understanding of how to improve fodder odor and to enhance terpene degradation by lactic acid bacteria fermentation.
Unplanned hospital readmission after surgical treatment for thoracic spinal stenosis: incidence and causative factors
Authors: Wang Hui , Wang Longjie , Sun Zhuoran , Jiang Shuai , Li Weishi 
Published: January 2021

Abstract
Background To assess the incidence and causative factors of unplanned hospital readmission within 90 days after surgical treatment of thoracic spinal stenosis (TSS).Methods Hospital administrative database was queried to identify patients who underwent surgical treatment of TSS from July 2010 through December 2017. All unplanned readmissions within 90 days of discharge were reviewed for causes and the rate of unplanned readmissions was calculated. Patients of unplanned readmission were matched 1:3 to a control cohort without readmission.Results Twenty-one patients (incidence of 1.7% in 1239 patients) presented unplanned hospital readmission within a 90-day period and enrolled as the study group, 63 non-readmission patients (a proportion of 1: 3) were randomly selected as the control group. Causes of readmission include pseudomeningocele (8 patients; 38%), CSF leakage combined with poor incision healing (6 patients; 29%), wound dehiscence (2 patient; 9%), surgical site infection (2 patients; 9%), spinal epidural hematoma (1 patient; 5%), inadequate original surgical decompression (2 patients; 9%). Mean duration from re-admission to the first surgery was 39.6±28.2 days, most of the patients readmitted at the first 40 days (66.7%, 14/21 patients). When compared to the non-readmitted patients, diagnosis of OPLL+OFL, circumferential decompression, dural injury, long hospital stay were more to be seen in readmitted patients. Conclusions The incidence of 90-day unplanned readmission after surgical treatment for TSS is 1.7%, CSF leakage and pseudomeningocele were the most common causes of readmission, the peak period of readmission occurred from 10 to 40 days after surgery, patients should be closely followed up within this period.
Dysbiosis of gut microbiota and its correlation with dysregulation of cytokines in psoriasis patients
Authors: Zhang Xinyue , Guo Kun , Shi Linjing , Sun Ting , Geng Songmei 
Published: January 2021

Abstract
Background: Psoriasis is an inflammatory skin disease associated with multiple comorbidities and substantially diminishes patients’ quality of life. The gut microbiome has become a hot topic in psoriasis as it has been shown to affect both allergy and autoimmunity diseases in recent studies. Our objective was to identify differences in the fecal microbial composition of patients with psoriasis compared with healthy individuals to unravel the microbiota profiling in this autoimmune disease.Results: We collected fecal samples from 30 psoriasis patients and 30 healthy controls, sequenced them by 16S rRNA high-throughput sequencing, and identified the gut microbial composition using bioinformatic analyses including Quantitative Insights into Microbial Ecology (QIIME) and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). Our results showed that different relative abundance of certain bacterial taxa between psoriasis patients and healthy individuals, including Faecalibacterium and Megamonas, were increased in patients with psoriasis. It’s also implicated that many cytokines act as main effect molecules in the pathology of psoriasis. We selected the inflammation-related indicators that were abnormal in psoriasis patients and found the microbiome variations were associated with the level of them, especially interleukin-2 receptor showed a positive relationship with Phascolarctobacterium and a negative relationship with the dialister. The relative abundance of Phascolarctobacterium and dialister can be regard as predictors of psoriasis activity. The correlation analysis based on microbiota and Inflammation-related indicators showed that microbiota dysbiosis might induce an abnormal immune response in psoriasis. Conclusions: We concluded that the gut microbiome composition in psoriasis patients has been altered markedly and provides evidence to understand the relationship between gut microbiota and psoriasis. More mechanistic experiments are needed to determine whether the differences observed in gut microbiota are the cause or consequences of psoriasis and whether the relationship between gut microbiota and cytokines was involved.
Use of a technology-based system to motivate older adults in performing physical activity: a feasibility study.
Authors: Knippenberg Els , Timmermans Annick , Palmaers Steven , Spooren Annemie 
Published: January 2021

Abstract
BackgroundMaintaining or initiating regular physical activity (PA) is important for successful aging. Technology-based systems may support and stimulate older adults to initiate and persevere in performing PA. The aim of the current study was to assess to which extent a customised Kinect system is 1) a credible tool to increase PA in older adults, 2) motivating to perform PA by older adults, and 3) easy to be used in older adults. MethodsA mixed-method cross-sectional feasibility study was performed in 5 aged care facilities in Flanders, Belgium. Aged participants were asked to perform a 20-30 minute test with the intelligent Activity-based Client-centred Training (i-ACT) system. After the test, the ‘Credibility and Expectancy Questionnaire’ (CEQ), the ‘Intrinsic Motivation Inventory’(IMI), the System Usability Scale (SUS), and semi-structured interviews were conducted in the older adults. Feedback was gathered using the thinking aloud method in both aged participants and healthcare professionals. ResultsA total of 48 older adults (20 males and 28 females, mean age=81.19 (SD=8.10)), were included. The scores pertaining to system credibility and expectancy, system usability, and motivation towards use were moderate to good. Participants reported that they liked using the i-ACT system, but that the context could be more attractive by adding more visualisations. Twelve professionals stated that they observed involvement in older adults but think that i-ACT is better used in day care centres. ConclusionsThis study indicates that i-ACT is a usable and motivational system to engage older adults to perform PA and therefore supports successful aging. Future research is necessary to investigate the efficacy of i-ACT to perform PA and the transfer to regain and/or maintain engagement in ADLs that older adults find meaningful and purposeful at an older age. Also, further development of i-ACT is advisable to adapt the i-ACT system towards implementation at the home of older adults.
Low serum parathyroid hormone is a risk factor for peritonitis episodes in incident peritoneal dialysis patients: a retrospective study
Authors: Yang Yuqi , Da Jingjing , Jiang Yi , Yuan Jing , Zha Yan 
Published: January 2021

Abstract
Background: Serum parathyroid hormone (PTH) levels have been reported to be associated with infectious mortality in peritoneal dialysis (PD) patients. Peritonitis is the most common and fatal infectious complication, resulting in technique failure, hospital admission and mortality. Whether PTH is associated with peritonitis episodes remains unclear.Methods: We examined the association of PTH levels and peritonitis incidence in a 7-year cohort of 270 incident PD patients who were maintained on dialysis between January 2012 and December 2018 using Cox proportional hazard regression analyses. Patients were categorized into three groups by serum PTH levels as follows: low-PTH group, PTH<150pg/mL; middle-PTH group, PTH 150-300pg/mL; high-PTH group, PTH>300pg/mL.Results: During a median follow-up of 29.5 (interquartile range 16-49) months, the incidence rate of peritonitis was 0.10 episodes per patient-year. Gram-positive organisms were the most common causative microorganisms (36.2%), and higher percentage of Gram-negative organisms was noted in patients with low PTH levels. Low PTH levels were associated with older age, higher eGFR, higher hemoglobin, calcium levels and lower phosphate, alkaline phosphatase levels. After multivariate adjustment, lower PTH levels were identified as an independent risk factor for peritonitis episodes [hazard ratio 1.643, 95% confidence interval 1.014-2.663, P=0.044].Conclusions: Low PTH levels are independently associated with peritonitis in incident PD patients.
Outcomes of infants born to pregnant women with syphilis: A nationwide study in Korea
Authors: Lim Joohee , Yoon So Jin , Shin Jeong Eun , Han Jungho , Lee Soon Min , Eun Ho Seon , Park Min soo , Park Kook In 
Published: January 2021

Abstract
Background. Despite the expansion of antenatal syphilis screening programs, congenital syphilis (CS) remains a concern. Purpose. This study aimed to analyze the manifestation and progress of CS, including treatment and follow-up, based on a nationwide study. Methods. From the Korean National Health Insurance Service database, a total of 548 infants were examined for CS during their first year of life from 2013 to 2018. Neurosyphilis and complications were investigated using the International Classification of Diseases-10 codes.Results. The birth rate of infants from mothers with syphilis was 2.8 per 10,000 live births for 5 years, which is not indicative of a decreasing trend. Overall, 148 infants were proven or highly probable or possible of having CS with treatment for 10 days; 66 infants were possible or less likely of having CS with only 1-day treatment. Jaundice (56%) was common, followed by hearing impairment (14%), renal disease (8%), and mental retardation (8%). Fourteen cases of neurosyphilis occurred. Infants with complications, including mental retardation, eye involvement, hearing impairment, or renal disease, were significantly associated with neurosyphilis (OR 8.49, P<0.0001). Of 250 patients who received treatment, 92.8% were treated with one medication: benzathine penicillin was used in 73% of patients. Only four patients were re-treated due to treatment failure. In addition to the treponemal test, fluorescent treponemal antibody-absorption was the most utilized tool for diagnosis and follow-up. Conclusion. Establishing standardized guidelines for the evaluation of CS, as well as the establishment of treatment regimens and follow up-plans for the disease, at a national level would help improve maternal and neonatal care and facilitate the eradication of CS in Korea.
Phenotypic and Molecular Characterization of the Capsular Serotypes of Pasteurella multocida Isolates from Pneumonic Cases of Cattle in Ethiopia
Authors: Yilma Mirtneh Akalu , Vemulapati Murthy Bhadra , Tefera Takele Abayneh , Yami Martha , Negi Teferi Degefa , Belay Alebachew , Derese Getaw , Leykun Esayas Gelaye 
Published: January 2021

Abstract
Background: Pasteurella multocida is a heterogeneous species and opportunistic pathogen associated with pneumonia in cattle. Losses due to pneumonia and associated expenses are estimated to be higher in Ethiopia with limited information about the distribution of capsular serotypes. Hence, this study was designed to determine the phenotypic and capsular serotypes of P. multocida from pneumonic cases of cattle. Methods: A cross sectional study with purposive sampling method was employed in 400 cattle from April 2018 to January 2019. Nasopharyngeal swabs and lung tissue samples were collected from clinically suspected pneumonic cases of calves (n = 170) and adult cattle (n = 230). Samples were analyzed using bacteriological and molecular assay.Results: Bacteriological analysis revealed isolation of 61 (15.25%) P. multocida subspecies multocida. Incidence was higher in calves 35 (57.38%) compared to adult cattle 26 (42.62%) at P < 0.5. PCR assay targeting KMT1 gene (~460 bp) confirmed P. multocida species. Capsular typing revealed the presence of serogroup A (hyaD-hyaC) gene (~1044 bp) and serogroup D (dcbF) gene (~657 bp) from 56 (91.80%) and 5 (8.20%) isolates, respectively. Isolation of P. multocida serotype A:3 highlights a new evidence in the study areas. Therefore, the current finding suggests further comprehensive studies on microbial diversity of respiratory infection in cattle to design effective control strategy.
Inhibition of Ref(2)P, the Drosophila homologue of the p62/SQSTM1 gene, increases lifespan and leads to a decline in motor function&nbsp;
Authors: Hurley Emily P. , Staveley Brian Ernest 
Published: January 2021

Abstract
Objective: Sequestosome 1 (p62/SQSTM1) is a multifunctional scaffold/adaptor protein encoded by the p62/SQSTM1 gene with function in cellular homeostasis. Mutations in the p62/SQSTM1 gene have been known to be associated with patients with Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and Parkinson Disease (PD). The aim of the present study was to create a novel model of human neurogenerative disease in Drosophila melanogaster by altering the expression of Ref(2)P, the Drosophila orthologue of the human p62/SQSTM1 gene. Ref(2)P expression was altered in all neurons, the dopaminergic neurons and in the motor neurons, with longevity and locomotor function assessed over time.Results: Inhibition of Ref(2)P resulted in a significantly increased median lifespan in the motor neurons, followed by a severe decline in motor skills. Inhibition of Ref(2)P in the dopaminergic neurons resulted in a significant, but minimal increase in median lifespan, accompanied by a drastic decline in locomotor function. Inhibition of Ref(2)P in the ddc-Gal4-expressing neurons resulted in a significant increase in median lifespan, while dramatically reducing motor function.
Technology-based Health Solutions for Cancer Caregivers to Better Shoulder the Impact of COVID-19: A Systematic Review Protocol
Authors: Su Zhaohui , McDonnell Dean , Liang Bin , Kue Jennifer , Li Xiaoshan , Šegalo Sabina , Advani Shailesh , Flores Bertha E , Wang Jing 
Published: January 2021

Abstract
Background: Cancer patients are particularly vulnerable to COVID-19, partially owing to their compromised immune systems and curbed or cut cancer healthcare services caused by the pandemic. As a result, cancer caregivers may have to shoulder triple crises: the COVID-19 pandemic, pronounced healthcare needs from the patient, and elevated need for care from within. While technology-based health interventions have the potential to address unique challenges cancer caregivers face amid COVID-19, limited insights are available. Thus, to bridge this gap, we aim to identify technology-based interventions designed for cancer caregivers and report the characteristics and effects of these interventions concerning cancer caregivers' distinctive challenges amid COVID-19. Methods: A systematic search of the literature will be conducted in PubMed, PsycINFO, CINAHL, and Scopus from the database inception to the end of March, 2021. Articles that center on technology-based interventions for cancer caregivers will be included in the review. The search strategy will be developed in consultation with an academic librarian who is experienced in systematic review studies. Titles, abstracts, and full-text articles will be screened against eligibility criteria developed a priori. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses procedures will be followed for the reporting process. Conclusions: COVID-19 has upended cancer care as we know it. Findings of this study can shed light on evidence-based and practical solutions cancer caregivers can utilize to mitigate the unique challenges they face amid COVID-19. Furthermore, results of this study will also offer valuable insights for researchers who aim to develop interventions for cancer caregivers in the context of COVID-19. In addition, we also expect to be able to identify areas for improvement that need to be addressed in order for health experts to more adequately help cancer caregivers weather the storm of global health crises like COVID-19 and beyond. Study Protocol Registration: PROSPERO CRD42020196301
Analysis of transverse vibration of wire rope in flexible hoisting system
Authors: Wu Shuiyuan , He Ping , Gong Xiansheng 
Published: January 2021

Taking the flexible hoisting system as the research object, the transverse vibration mathematical model of the steel wire rope of the winding hoisting system is established, and the transverse vibration displacement, velocity and acceleration of the steel wire rope at 18 m away from one end of the wire rope under the sine excitation at other end is obtained through the comparison and verification of the results from the mathematical model, mechanical model and experiment. The results show that: for the length of the wire rope of 20 m, under the sine excitation at the end of amplitude of 0.002 m and frequency of 20 Hz, the transverse vibration displacement at 2 m from one end of the wire rope with length of 20 m is basically between –0.005 m and 0.005 m, the transverse vibration velocity at 2 m from one end of the wire rope is basically between –0.04 m/s and 0.04 m/s, and the transverse vibration acceleration of the wire rope is basically between –0.5 m/s2 and 0.5 m/s2. And the transverse vibration displacement decreases near the end, meanwhile the transverse vibration frequency increases with the reduction of length of vertical section of wire rope.