bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Study of Human FBXW7 Deleterious nsSNP's Functional Inference and Susceptibility to Gynaecological Cancer
Authors: Vasuki.K Archana , Christy.H Jemmy 
Published: September 2021

Abstract
Cancer is one of the world's major causes of mortality, and it plays a most important role in the world's declining life expectancy. F-box and WD-40 domain protein 7 (FBXW7), a typical participant of the F-box family of proteins, has been considered as an antitumor protein and one of the maximum deregulated ubiquitin-proteasome system proteins in uterine carcinosarcoma, endometrial clear cell carcinoma and cervical carcinoma with the greatest prevalence of alterations. FBXW7 variants with known clinical significance, as well as nsSNP’s in the F-Box and WD40 domains, were evaluated using functionality prediction web resources. Upon analysing the seventy-three deleterious nsSNP’s impact on protein stability and function, we identified that forty-one nsSNP’s of WD40 domain and three of F-Box domain imply decreased stability of the FBXW7 structure. Next to TP53 and PTEN, FBXW7 was reported with the highest percentage of arginine substitution among mutations related to cancer. The current research concentrated on two arginine residue locations (Arg465, Arg505) within the WD40-repeat domain, which is vital for substrate binding. Computational analysis revealed that significant deviation in stability and structural configuration of mutants R505L, R465H, R465P, R505G, R505C, R465C R505S and R505L structures. Protein–protein interaction network of FBXW7 populated with promising hub proteins NOTCH1, c-Myc, CCNE1, STYX, KLG5, SREB1, NFKB2, SKP1, CUL1, thus alteration in the FBXW7 leads to aberration in their signalling pathways as well as their substrate binding ability makes this protein as attractive target for personalized therapeutic intervention.
Prediction of Postoperative Survival Level of Esophageal Cancer Patients Based on Kaplan-Meier(K-M) Survival Analysis and Gray Wolf Optimization (GWO)-BP Model
Authors: Liang Enhao , Wang Yanfeng , Sun Junwei , Wang Lidong , Zhao Xueke , Song Xin 
Published: September 2021

Abstract
Background: Esophageal squamous cell carcinoma (ESCC) is a global safety problem, especially the low 5-year survival rate of patients after surgery, and their healthy life after surgery is directly threatened.Methods: Kaplan-Meier(K-M) survival analysis is used to screen the blood indexes of patients with ESCC. The gray wolf algorithm (GWO) is introduced to optimize the weight threshold of back-propagation (BP) neural network, and a prediction model based on K-M-GWO-BP is established.Results: According to the influencing factors of postoperative survival, the postoperative survival level of patients is predicted. K-M survival analysis is used to analyze the relevant risk factors, the redundant variables are eliminated, and the whole structure of the neural network is simplified. The initial weight of BP neural network is optimized by GWO.Conclusions: BP neural network model, PSO-BP, GA-BP, SSA-BP, GWO-BP, K-M-BP, K-M-PSO-BP, K-MGA-BP, K-M-SSA-BP and K-M-GWO-BP are compared, the prediction accuracy of K-M-GWO-BP neural network model is the best.
Enhance nitrogen removal in bioretention cells with addition of hydrothermal pre-treated pine barks as external carbon source
Authors: Tuo Jing , Cao Shiwei , Li Muzi , Guo Rong 
Published: September 2021

Abstract
The problem of poor carbon source is a common factor limiting the nutrients removal in bioretention cells (BRCs). This study aimed to investigate the feasibility of using modified biomass in BRCs filled with a mixture of fly ash ceramsite and pumice fillers to enhance nitrogen removal. Different pretreatment methods (hydrothermal-treated, acid-treated and alkali-treated) were attempted, and hydrothermal pretreatment showed a best performance in carbon release ability. The scanning electron microscopy showed that the lignin in hydrothermal pretreated pine barks (H-PBs) was destroyed, and the fiber structure became thinner with more irregular folds, which improved the accessibility of cellulose and attachment of microorganisms. The addition of H-PBs significantly enhanced the nutrients removal in BRCs, and the removal rates of TN and NO3−-N increased by 23.25% and 38.22% compared with those in BRC-A (without external carbon source), but the removal rate of NH4+-N was inferior to BRC-A. Besides, the large carbon release amount of H-PBs did not deteriorate the effluent quality, with COD removal rate of 87.98% in the 48 d. These results indicate that the BRCs by adding H-PBs could intensify the denitrification process.
Cultural Adaptation, Reliability and Validation of the Arabic Örebro Musculoskeletal Pain Questionnaire in Patients With Low Back Pain
Authors: Alrwaily Muhammad Z. , Alanazi Fahad 
Published: September 2021

Abstract
BACKGROUND: The Örebro Musculoskeletal Pain Questionnaire (ÖMPQ) assesses the psychosocial factors in people with complaints of musculoskeletal disorders and predict those likely to develop persistent symptoms. OBJECTIVE: To culturally-adapt and assess the validity of the ÖMPQ in an Arabic population with low back pain (LBP).METHODS: The ÖMPQ was translated into Arabic. Eighty-four patients completed the questionnaires at baseline, 2 days later, and 3 months follow-up. The test-retest reliability, interclass correlation coefficient (ICC), specific agreement, predictive validity and content validity were assessed.RESULTS: For construct validity, the Arabic ÖMPQ (A-ÖMPQ) had a moderate (r ≥ 0.3, < 0.5) to high (r ≥ 0.5) correlation with pain, disability, fear-avoidance and catastrophizing questionnaires. The test-rest reliability showed was high ICC2,1=0.92 (95% CI: .83 - .96). The A-ÖMPQ score at baseline can significantly predict disability at 3 months F(1,82)=33.87, p<.01; R2=.29.CONCLUSIONS: The translation of the A-ÖMPQ into Arabic was successful. The A-ÖMPQ showed very good psychometric properties, and thus can be used to evaluate the psychosocial factors amongst patients with LBP.
Machine-Learning Predictive Models For Dependency On Smartphones Based On Risk Factors
Authors: Giraldo-Jiménez Claudia F. , Gaviria-Chavarro Javier , Urrutia-Valdés Alexander , Bedoya-Pérez José Fernando , Sarria-Paja Milton Orlando 
Published: September 2021

Abstract
Background: Machine learning techniques allow highly accurate prediction of different tasks by measuring the event probabilities. This research proposes a prediction model for dependency on smartphones based on machine learning techniques. Methods: We performed an analytical observational study with a retrospective case–control approach; the different classification methods used were decision tree, random forest, logistic regression, and support vector machine. The sample demographic included 1228 students from a private university in Cali. The tests were 1) smartphone dependency assessment and 2) the Nordic musculoskeletal symptoms questionnaire. Results: It was found that some of the variables related to smartphone dependency are academic curriculum, school, marital status, socioeconomic status, rules, discussions, and discrimination. Conclusions: The support vector machine model evidences highest prediction precision for smartphone dependency, obtained through the stratified-k-fold cross-validation technique.
Left Portal Vein Thrombosis Complicated by Acute Cholecystitis Cause Liver Atrophy: A Case Report
Authors: Wu Cheng-Hsien , Wong Yon-Cheong , Lin Being-Chuan 
Published: September 2021

Abstract
Background: Portal vein thrombosis (PVT) was infrequently complicated by acute cholecystitis. The clinical signs of PVT are usually non-specific and subclinical. The treatment aim was to re-canalize the portal vein and to avoid serious complications. An early anticoagulation treatment would result in favorable outcome. Case Report: We present a case of acute cholecystitis with sole left portal vein thrombosis causing left liver atrophy in a 59-year-old woman.Conclusions: While the surgeon is familiar with this uncommon condition, the PVT could be detected on the pre-operative images through a tailored CT or MRI. The condition of PVT is often subclinical and might complicate liver atrophy, an early anticoagulation treatment would result in a favorable outcome.
Mind the Gap: Estrogen receptor beta (ERβ) in astrocytes is a therapeutic target to prevent cognitive problems at menopause.
Authors: Voskuhl Rhonda , Itoh Noriko , Meyer Cassandra , Itoh Yuichiro , Mangu Darian , Suen Timothy , Jang Ellis , Tse Vincent , MacKenzie-Graham Allan 
Published: September 2021

Abstract
Aging is a risk factor for cognitive decline and susceptibility to neurodegenerative diseases. Some aspects of aging, like the loss of sex hormones, may be preventable. Menopause is associated with cognitive deficits and brain atrophy. Since standard hormone replacement therapy (HRT) does not mitigate these brain aging outcomes, a gap in knowledge involves understanding brain region-specific, cell-specific, and receptor-specific mechanisms underlying this neurodegeneration. Here, cognitive testing and in vivo magnetic resonance imaging demonstrated that ovarian hormones in female mice at midlife protect against hippocampal-dependent cognitive impairment and dorsal hippocampal atrophy. Further, this neuroprotection in females at midlife is lost in mice with selective deletion of estrogen receptor beta (ERβ) in astrocytes, but not neurons. This preclinical evidence identifies ERβ in astrocytes as a novel therapeutic target to prevent hippocampal-dependent cognitive deficits and reduce posterior hippocampus atrophy in menopausal women, a major unmet need in half the population.
Seasonal Variation and Tissues Specificity of Endophytic Fungi of Dillenia Indica L. and their Extracellular Enzymatic Activity.
Authors: Kumar Vijay , Prasher I. B. 
Published: September 2021

Abstract
Endophytes are an unexplored group of microbes that live inside the living tissues of healthy plants without any visible symptoms of the disease. This study focused on the exploration and characterisation of culturable endophytic fungi inhabiting in different parts the medicinal plant Dillenia indica L during different seasons. A total of 2360 segments from different parts like leaves (820), stems (820) and fruits (720) were screened to isolate endophytic fungi from the plants growing in Botanical Gardens of Panjab University, Chandigarh (India), during different seasons i.e., Summer, Spring, Autumn and Winter of the years 2018 and 2019. A total of twenty-five (25) species of fungi belonging to twenty (20) genera were isolated from the selected plant during different seasons. The plant has the highest affinity for Lasiodiplodia theobromae followed by Colletotrichum gloeosporioides and Cladosporium cladosporides. The percentage frequency was found to be 96%, 64% and 20% for leaves, stems and fruits. The colonization rate for leaves, stems and fruits was 55.6%, 25.6% and 8.8%. The isolated fungi were identified by morphological, microscopic and molecular characteristics. Monsoon (Rainy season) had the highest number of isolates (312 isolates), followed by summer (208 isolates), Winter (164 isolates) and Autumn (114 isolates). Species diversity was highest during the rainy season (19 species) and lowest during the Winter (12 species). The isolated fungi also produce extracellular enzymes such as amylase, lipase, protease, asparaginase, cellulase and ligninolytic enzymes. The results indicate that Dillenia indica L. harbors novel endophytic fungi having agricultural, medical and industrial applications.
Magnetic and Restivity Investigation of Geologic Structures in the Basement Complex of Aran-Orin, Kwara-State, Nigeria.
Authors: Adeyanju 'Muyiwa Adekunle , Fatoye Oluwaseun Victoria , Oyanameh O.E 
Published: September 2021

Abstract
The study aims to integrate magnetic and vertical electrical sounding (VES) resistivity methods to determine groundwater prospective in part of Aran-orin Sheet 224. A total of three traverses were established in the study area for the vertical electrical sounding using the Schlumberger electrode configuration. A total of 17 VES points was established using the ABEM Terrameter SAS 1000C model with maximum half-current electrode spacing (AB/2) of 120m. A total of eight traverses were established for the magnetics survey with station intervals of 10 m and inter-profile spacing of 100 m. The magnetic and VES data were qualitatively and quantitatively interpreted using IPI2WIN and OASIS MONTAJ package respectively. The geo-electric sections reveal a maximum of 3-4 layers beneath the sub-surface an overburden thickness ranges from 8.2 m to 64.9 m and the corresponding lithology inferred are topsoil, weathered Rock, fractured basement and fresh basement. The depth to basement using half-width method showed that the depth ranges from 8.4-56.04 m, which corresponds with the electrical survey.
Changes in Wrist Joint Contact Area Following Radial Shortening Osteotomy for Kienböck Disease
Authors: Shiota Junki , Momma Daisuke , Matsui Yuichiro , Inoue Nozomu , Kondo Eiji , Iwasaki Norimasa 
Published: September 2021

Abstract
We hypothesized that the contact area of the articular surface of the wrist joint could be evaluated using a custom-designed analytical program. The aim of the study was to compare the articular contact area of the wrist joint before and after radial shortening osteotomy for Kienböck disease. Nine wrists of 9 patients underwent radial shortening osteotomy for Kienböck disease. Computed tomography (CT) images of the wrist joint were reconstructed using a 3D reconstruction software package. Radioscaphoid and radiolunate joint contact areas and translation of the joint contact area from preoperative to postoperative were calculated using customized software. All patients reported a marked reduction of wrist pain at the 12-month follow-up. The contact area was altered following radial shortening, and the center of the contact area was translated radially and dorsally postoperatively. CT-based analysis revealed that the center of the contact area translated radially following radial shortening.
Health-Related Quality Of Life And Its Determinants Among Recreational Drug Users In A Rural Area In Cameroon: A Cross-Sectional Study
Authors: Njingu Atabong Emmanuel , Jabbossung Fombo Enjeh , Sunjo Nyuydzedze Stanley , Ayongi Stephen Eyong Njang , Kemndah Nembulefac Derick 
Published: September 2021

Abstract
Background

This study was aimed to evaluate the health-related quality of life (HRQoL) and its drivers among recreational drug users, compared to non-users using WHOQOL-BREF.
Methods

A total of 246 recreational drug users and 141 non-recreational drug users were recruited using consecutive sampling of adults in the community. Socio-demographic data, data related to recreational drug use and HRQoL were collected. Data were compared using t-test, analysis of variance and chi-square test. Determinants of HRQoL were obtained using multivariate regression models.
Results

The mean overall quality of life (OQOL) score was significantly higher for non-recreational drug users compared to users (75.89 ± 22.64 vs 61.08 ± 23.94, respectively, p < 0.001), non-users as well had significantly higher mean scores across all four domains of WHOQOL-BREF. After multivariable adjustment, use of recreational drugs negatively affected the psychological domain (β=-4.17, 95% CI -8.22 to -0,13) and the environmental domain (β=-4.47, 95% CI -8.48 to -0.45). Years of recreational drug use affected the social relationship domain (β=-0.55, 95% CI -0.88 to -0.22), OQOL (β=-0.57, 95% CI -0.94 to -0.19), and general health satisfaction (β=-0.71, 95% CI -1.08 to -0.35). Number of recreational drugs used contributed to poorer physical health (β=-1.45, 95% CI -2.57 to -0.33), psychological domain (β=-2.04, 95% CI -3.18 to -0.91), social relationship domain (β=-1.87, 95% CI -3.39 to -0.35) as well as overall quality of life (β=-2.13, 95% CI -3.89 to -0.37). Besides recreational drugs, monthly income also affected physical health (β = 5.17, 95% CI 2.96 to 7.38), psychological domain (β = 3.34, 95% CI 1.10 to 5.58), environmental domain (β = 2.64, 95% CI 0.42 to 4.85) and also the OQOL (β = 4.16, 95% CI 0.70 to 7.62).
Conclusions

Our findings suggest that, recreational drugs significantly negatively affect the health-related quality of life of its users. People who use multiple recreational drugs and longer years of recreational drug use had a more widespread effect across the health domains. Higher monthly income could improve the HRQoL of recreational drug users.
A Study of the Effect of Number of Births on the Disability Status of China's Elderly Women
Authors: Yang Hua-lei , Zhang Shuo , Yao Yi-dan , Zhang Si-qing , Wu Yuan-yang , Xie Lin , Li Zhi-yun , Shen Zheng 
Published: September 2021

Abstract
Purpose

Under the background of aging population, the disability of the elderly is more serious, and childbirth affects the health status of elder women. The aim of this paper was to examine the relationship between the number of births and the risk of maternal disability in later life.
Methods

Based on data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2018, 4,686 elder women were selected as study population. The logistic regression analysis was conducted to estimate the effect of number of children and other fertility behaviours on the risk of disability and to test whether there were urban-rural differences and gender differences.
Results

A high number of births significantly reduced the risk of disability among elder women. For each additional birth, the odds ratio of maternal disability in later life decreased by 4.3%, especially elder women with fewer than five births. Heterogeneity analysis found that this effect was present in the urban areas, and that an increase in the number of births increased the probability of disability for both fathers and rural mothers, but this result was not significant. Further examination showed that later age at last birth and longer childbearing period both significantly reduced the probability of disability.
Conclusions

This paper found an association between early fertility behaviour and the risk of disability in later life. We need to promote urbanisation and to have children within the right limits, not too many, and improve relevant supporting measures to ensure the health of female elderly in later year.
The dissemination of the “Shell sentence” and compliance with the Paris Agreement
Authors: Lopez Luis , Arce Guadalupe , Cadarso María , Ortiz Mateo , Zafrilla Jorge 
Published: September 2021

Abstract
The extension of Shell’s landmark sentence to all the foreign affiliates of multinational enterprises (MNEs) would imply a global emissions reduction of 2.76 GtCO2. Between 28% and 43% of the total 2030 emissions reduction target of not exceeding 2°C would be achieved. While 91% of multinational affiliates’ output belongs to high-income countries, 54% of their emissions occur in low- and middle-income countries. Therefore, these commitments could crucially help emerging countries meet their mitigation targets. We place a special focus on MNEs in the vehicle industry and find that the current targets disclosed in the sustainability reports of the leading automotive MNEs (such as Volkswagen, Toyota, Nissan, and Ford) ignore the upstream emissions of their production, as they consider only scopes 1 and 2. This biased approach would have them reducing only 8%-22% of the required reductions of their upstream emissions if the Shell sentence were to be extended to the automotive industry.
Investigation on the Inspection Technology of GH3535 Alloy Butt Weld With Linear Array Probe
Authors: A Xiaodan Yuan , B Yuan Zhang , Li Zhijun , C Kun Yu , D Jinlong Wang 
Published: September 2021

Abstract
The critical problem to accurately characterizing defects in GH3535 alloy weld is the deflection of the acoustic beam and scattering due to the coarse columnar grains. Signal-to-noise ratio is an important index to indicate whether the grain scattering is severein the ultrasonic inspection. In this paper, the phased array ultrasonic testing of GH3535 alloy butt weld was studied using sector scan mode with linear array probe. The soundfield characteristics of the linear array probe with different focusing parameters were analyzed, and the signal-to-noise ratio in the detection was calculated. The results show that: the acoustic beam of the linear array probe can cover the weld,based on the removal of weld reinforcement. The signal-to-noise ratio of transverse hole with φ3mm located at the weld-fusion lineis more than 15dB, when the front end ofthe probe is located directly above the transverse hole of weld-fusion line.
Differences between treadmill and cycle ergometer cardiopulmonary exercise testing results in amateur triathletes and their association with body composition and body mass index
Authors: Price Szymon , Wiecha Szczepan , Cieśliński Igor , Śliż Daniel , Kasiak Przemysław Seweryn , Gruba Grzegorz , Mamcarz Artur , Lach Jacek 
Published: September 2021

Abstract
Cardiopulmonary exercise testing (CPET) is the method of choice to assess aerobic fitness. Previous research was ambiguous as to whether treadmill (Tr) and cycle ergometry (CE) results are transferrable or different between testing modalities in triathletes. The aim of this paper was to investigate the differences in HR and VO2 at maximum exertion and at anaerobic threshold (AT) and respiratory compensation point (RCP) and evaluate their association with body fat (BF), fat free mass (FFM), and body mass index (BMI). 143 adult (n = 18 female), amateur, Caucasian triathletes had both Tr, and CE CPET performed. The male group was divided into < 40 years (n = 80) and > 40years (n = 45). Body composition was measured with bioelectrical impedance before tests. Differences were evaluated using paired T-tests and associations were evaluated in males using multiple linear regression (MLR). Significant differences were found in VO2 and HR at maximum exertion, at AT and at RCP between CE and Tr testing, in both males and females. VO2AT was 38.8(± 4.6) ml/kg/min in Tr vs 32.8(± 5.4) in CE in males and 36.0(± 3.6) vs 32.1(± 3.8) in females (p < 0.001). HRAT was 149 (± 10) bpm in Tr vs 136 (± 11) in CE in males and 156 (± 7) vs 146 (± 11) in females (p < 0.001). VO2max was 52 (± 6) ml/kg/min vs 49 (± 7) in CE in males and 45.3 (± 4.9) in Tr vs 43.9 (± 5.2) in females (p < 0.001). HRmax was 183 (± 10) bpm in Tr vs 177 (± 10) in CE in males and 183 (± 9) vs 179 (± 10) in females (p < 0.001). MLR showed that BMI, BF and FFM are significantly associated with differences in HR and VO2 at maximum, AT and RCP in males aged > 40. Both tests should be used independently to achieve optimal fitness assessment and further training planning.