bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between MDR1 C3435T genetic polymorphism and the risk of multidrug-resistant epilepsy in Egyptian children
Authors: Elmagid Dina Salama Abd , Abdelsalam Maha , Magdy Hend , Tharwat Noha 
Published: March 2021

Abstract
Background
Epilepsy is a chronic disease affecting about 2% of the population and is considered a serious neurological disease. Despite its good prognosis, 20–30% of epileptic patients were not cured of their seizures even with the many trials of antiepileptic drug (AED) therapy. The resistance mechanism is still unclear, maybe due to the effect of the genetic factors on the bioavailability of the drugs. Consequently, the association between therapy resistance and the presence of a gene called “multidrug resistance 1 (MDR1)” had been proposed. Thus, the present study aimed to understand the relationship between the genetic polymorphism of MDR1C3435T and the resistance to AEDs.

Result
A non-significant association was found between MDR1 C3435T single-nucleotide polymorphism (SNP) and drug-resistant epilepsy. However, there was statistical significance in the association between the drug type and the genotype distribution, in cases that were maintained on sodium valproate and MDR1C3435T genotype.

Conclusion
Possible involvement of the MDR1 gene C 3435T polymorphism with sodium valproate resistance clarifies the importance of genetic variability in response to the drug and may help to find novel genetic therapy for epilepsy, by targeting the biological mechanisms responsible for epilepsy in each specific individual. Future studies with bigger sample sizes and in other racial populations will be necessary.
Meta-analysis: COVID-19 diagnosis in chest CT—master key for radiologists
Authors: Hassanipour Soheil , Azadbakht Omid , Dehnavi Zari , Shafiee Mohsen , Badeenezhad Ahmad , Nikbakht Hossein-Ali , Scandarkolaei Parsa Faghani , Bostan Hassan 
Published: March 2021

Abstract
Background
COVID-19 was discovered in February in China. Due to the high prevalence of the disease, early detection and rapid isolation of patients are the vital points for controlling the outbreak. The purpose of this study was to determine the correct location of chest CT scan in the diagnosis of COVID-19.

Main text
The current study is a systematic review and meta-analysis. 2959 papers were found in all national and international databases. The study has been reported based on the PRISMA checklist. All analyses were done by CMA Ver. 2 software. The statistical analysis results show that the GGO observation level in the available shape was 46% in CT scan results, and the consolidation observation level in the general form was 33% in CT scan results. Pleural effusion was 7%, and linear opacity observation level was 24% in CT scan results in the general form. The CT scan test sensitivity level was gained 94.7%, and PCR test sensitivity level was achieved as 94.8%. This level was 89% in the early stage.

Conclusion
The chest CT has about 24% higher diagnostic sensitivity than the PCR test, in the early stage. GGO revealed a declining process and also indicates that GGO is an early symptom of the disease in CT scan. Linear opacity is the reason behind the initial dyspnea in coronavirus suffering patients referring to the medical centers. The extra-pulmonary lesions increase in the last stage of the disease that makes the patient’s worse.
Coordinated fuzzy operation of battery energy storage and resistive brake for mitigation of SSR oscillations
Authors: Fayez Mohamed , Bendary Fahmy , El-Hadidy Mohamed , Mandor Mohamed 
Published: March 2021

AbstractThe work presented herein is focusing on mitigating sub-synchronous-resonance (SSR) oscillatory torque and speed responses developed in power network equipped with series capacitor compensation as an outcome of the network perturbations. The mitigation effect of a battery-energy-storage (BES) controlled via a fuzzy-logic-controller (FLC) is explored. It is also explored accompanied by a fuzzy-bases resistor brake controlled via FLC. The IEEE second benchmark system is selected as a test grid under the MATLAB™/Simulink simulation environment. The signal utilized for the propositioned controller is the alternator rotor speed deviation. The key conclusions of this investigation are the employment of a BES in the discharging mode alone might be utilized to alleviate the SSR relative speed, and torque oscillations, the BES employment accompanied with dynamic resistive brake is supplying faster-decaying rates for the SSR oscillations in observation with the BES employment only.
Multimodal surface-wave tomography to obtain S- and P-wave velocities applied to the recordings of unmanned aerial vehicle deployed sensors
Authors: Khosro Anjom Farbod , Browaeys Thomas Jules , Socco Laura Valentina 
Published: March 2021

Exploration seismic surveys in hard-to-access areas such as foothills and forests are extremely challenging. The Multiphysics Exploration Technologies Integrated System (METIS) research project was initiated to design an exploration system, facilitating the acquisition in these areas by delivering the receivers from the sky using unmanned aerial vehicles. Air dropping of the sensors in vegetated areas results in an irregular geometry for the acquisition. This irregularity can limit the application of conventional surface wave methods. We have developed a surface wave workflow for estimating the S-wave velocity ([Formula: see text]) and P-wave velocity ([Formula: see text]) models and that supports the irregular geometry of the deployed sources and receivers. The method consists of a multimodal surface-wave tomography (SWT) technique to compute the [Formula: see text] model and a data transform method (the wavelength/depth [W/D] method) to determine the Poisson’s ratio and [Formula: see text] model. We applied the method to the METIS’s first pilot records, which were acquired in the forest of Papua New Guinea. Application of SWT to the data resulted in the first 90 m of the [Formula: see text] model. The W/D method provided the Poisson’s ratio averaged over the area and the [Formula: see text] model between 10 and 70 m from the surface. The impact of the acquisition scale and layout on the resolution of the estimated model and the advantages of including the higher modes of surface waves in the tomographic inversion are assessed in detail. The presence of shots from diverse site locations significantly improves the resolution of the obtained model. Including the higher modes enhances the data coverage and increases the investigation depth.
Glassy gravity
Authors: De Giuli Eric , Zee A. 
Published: March 2021

Abstract
Euclidean quantum gravity is reconsidered, in the conformal mode approximation. Applying techniques from glass theory, we argue that the Euclidean partition function hides metastable states, which can be counted. This may reconcile conflicting results on the uniqueness of the de Sitter vacuum, and may be relevant to the cosmological constant problem.
A field theory in Randers-Finsler spacetime
Authors: Silva J. E. G. 
Published: March 2021

Abstract
Finsler geometry is a natural arena to investigate the physics of spacetimes with local Lorentz violation. The directional dependence of the Finsler metric provides a way to encode the Lorentz-violating effects into the geometric structure of the spacetime. Here, a classical field theory is proposed in a special Finsler geometry, the so-called Randers-Finsler spacetime, where the Lorentz violation is produced by a background vector field. By promoting the Randers-Finsler metric to a differential operator, a Finsler-invariant action for the scalar, gauge and fermions are proposed. The theory contains nonlocal terms, as in the Very Special Relativity based theories. By expanding the Lagrangian, minimal and nonminimal Standard Model Extension terms arise, revealing a perturbative Lorentz violation. For a CPT-even term, the Carrol-Field-Jackiw and derivative extensions are obtained.
Continuous photon Hall effect on metal surface
Authors: Gao Qi , Zhou Yun-Song , Zhao Li-Ming 
Published: March 2021

Abstract
The continuous photon Hall effect excited in a surface plasmon polariton system is proposed and realized theoretically, in which the parallel incident light illuminates the small ball nearing the surface. The scattering direction can be continually modulated in the large range of almost 180 degree by the elliptical polarization state of the incident light. The physical reason is displayed intuitively by the component waves interference principle.
Effect of magnetism on lattice dynamics in metallic chromium
Authors: Dubiel Stanisław M. , Żukrowski Jan 
Published: March 2021

Abstract
A single-crystal sample of chromium doped with

Sn was studied by means of a transmission Mössbauer spectroscopy in the temperature range of

310–315 K. An anomaly in the temperature behavior of the center shift was found at

313 K, a temperature that coincides well with the Néel temperature of chromium. The anomaly gives evidence that the vibrations of atoms in the studied system are affected by the magnetism.
Broadband seismic metamaterial with an improved cylinder by introducing plus-shaped structure
Authors: Xu Rui , Muzamil Muhammad , Fan Li , Yuan Keke , Yang Hongwu , Du Qiujiao 
Published: March 2021

Abstract
The narrow bandgap of a seismic metamaterial dramatically limits its application in attenuating seismic waves for securing buildings. This research proposes an improved cylinder-type seismic metamaterial by introducing plus-shaped to widen the bandgap. The propagation of seismic waves through a three-dimensional sample of seismic metamaterial is calculated to show its efficiency of the earthquake shielding using the finite-element method based on Floquet-Bloch theory. By comparison to the common seismic metamaterial consisting of simple cylinder structures, it is found that our metamaterial based on cylinder with plus-shaped structures can yield a three times relative bandgap width for seismic surface waves, which is more suitable for practical applications. Moreover, the bandgap depends on the constraint of geometric parameters and elastic parameters, and can be easily tuned to higher frequency for other phenomena such as vibration and noise attenuation by tailoring those parameters.
Symmetry breaking in single-crystal SrTiO3 plates: EPR manifestations
Authors: Gabbasov B. F. , Gracheva I. N. , Rodionov A. A. , Kiiamov A. G. , Nikitin S. I. , Zverev D. G. , Trepakov V. A. , Dejneka A. , Jastrabik L. , Yusupov R. V. 
Published: March 2021

Abstract
Results of the electron paramagnetic resonance (EPR) studies of Fe3+ and Mn4+ impurity centers in high-quality single-crystal SrTiO3 plates with thickness

are presented. Impurities served the paramagnetic probes of the crystal structure. Analysis of the collected data indicates that the symmetry of the crystal structure of thin (001) and (110) oriented strontium titanate plates above

lowers in the bulk from the cubic to tetragonal. The structure of this high-temperature tetragonal state is different from that of the conventional low-temperature antiferrodistorsive phase and has not been reported for SrTiO3 before. It is shown that the effect does not originate from the residual stress; its magnitude and particular manifestations depend on plate orientation, surface quality and geometry of a sample. Peculiarities of the observed phenomenon are presented and the possible scenario of its realization is discussed.
A lineage-specific requirement for YY1 Polycomb Group protein function in early T cell development
Authors: Assumpção Anna L. F. V. , Fu Guoping , Singh Deependra K. , Lu Zhanping , Kuehnl Ashley M. , Welch Rene , Ong Irene M. , Wen Renren , Pan Xuan 
Published: March 2021

ABSTRACTYin Yang 1 (YY1) is a ubiquitous transcription factor and mammalian Polycomb Group protein (PcG) with important functions for regulating lymphocyte development and stem cell self-renewal. YY1 mediates stable PcG-dependent transcriptional repression via recruitment of PcG proteins that result in histone modifications. Many questions remain unanswered regarding how cell- and tissue-specificity is achieved by PcG proteins. Here, we demonstrate that a conditional knockout of Yy1 in the hematopoietic system results in an early T cell developmental blockage at the double negative (DN) 1 stage with reduced Notch1 signaling. There is a lineage-specific requirement for YY1 PcG function. YY1 PcG domain is required for T and B cell development but not necessary for myeloid cells. YY1 functions in early T cell development are multicomponent and involve both PcG-dependent and -independent regulations. Although YY1 promotes early T cell survival through its PcG function, its function to promote the DN1-to-DN2 transition and Notch1 expression and signaling is independent of its PcG function. Our results reveal how a ubiquitously expressed PcG protein mediates lineage-specific and context-specific functions to control early T cell development.
Use of chicken feather meal fermented with Bacillus subtilis in diets to increase the digestive enzymes activity and nutrient digestibility of silver pompano Trachinotus blochii (Lacepede, 1801)
Authors: Adelina Adelina , Feliatra Feli , Siregar Yusni Ikhwan , Putra Iskandar , Suharman Indra 
Published: March 2021

Background: Feather has the potential to be used as a fish feed ingredient because it has high protein content (80-85%), and is rich in amino acids arginine, leucine, isoleucine and valine. However, the protein consists mainly of keratin, which is classified as fiber that is difficult to digest. Therefore, to improve digestibility, the keratin protein is degraded using microbial Bacillus subtilis. This study aimed to determine the digestibility of fermented feather meal (FFM) in silver pompano (Trachinotus blochii) diets and to observe the histological structure of their intestines after digestion. Methods: The method used was a one factor experiment with five treatments and three replications each, which were: diet without FFM, diet containing 10% FFM, 20%, 30% and 40%. The diets were given to juvenile silver pompano (with average body weight of 8.56 ± 0.18 g) and stocked in 15 similar 20-L plastic jars with 10 fish per jar in a density of 100 L capacity container. The experimental diets were given three times daily at approximately 8.00 AM, 12.00 PM and 5.00 PM to apparent satiation for 60 days. Results: The results showed that the use of FFM increased the activity of digestive enzymes (protease and lipase), but reduced the amylase activity of silver pompano, which was significantly different between treatments (P <0.05). Meanwhile, the diet containing 20% FFM produced the highest feed and protein, which are 37.05% and 67.24%, respectively. This was significantly different from other treatments (P <0.05), and was effectively absorbed by fish intestines. Conclusion: The addition of chicken feather meal fermented with Bacillus subtilis could increase the activity of protease and lipase enzymes and nutrient digestibility of silver pompano but not amylase activity.
The Private Impact of Public Data: Landsat Satellite Maps Increased Gold Discoveries and Encouraged Entry
Authors: Nagaraj Abhishek 
Published: March 2021

How does public data shape the relative performance of incumbents and entrants in the private sector? Using a simple theoretical framework, I argue that public data reduces investment uncertainty, facilitates the discovery of new market opportunities, and increases the relative market share of new entrants relative to incumbents. I shed light on these predictions by estimating the impact of public data from Landsat, a U.S. National Aeronautics and Space Administration satellite mapping program, on the discovery rates of new deposits by incumbents (seniors) and entrants (juniors) in the gold exploration industry. I exploit idiosyncratic timing variation and cloud cover in Landsat coverage across regions to identify the causal effect of public data on the patterns of gold discovery. I find that Landsat data nearly doubled the rate of significant gold discoveries after a region was mapped and increased the market share of new entrants from about 10% to 25%. Public data seem to play an important, yet relatively underexplored, role in driving performance differences across firms. This paper was accepted by Ashish Arora, entrepreneurship and innovation.
Combining Probability Forecasts: 60% and 60% Is 60%, but Likely and Likely Is Very Likely
Authors: Mislavsky Robert , Gaertig Celia 
Published: March 2021

How do we combine others’ probability forecasts? Prior research has shown that when advisors provide numeric probability forecasts, people typically average them (i.e., they move closer to the average advisor’s forecast). However, what if the advisors say that an event is “likely” or “probable?” In eight studies (n = 7,334), we find that people are more likely to act as if they “count” verbal probabilities (i.e., they move closer to certainty than any individual advisor’s forecast) than they are to “count” numeric probabilities. For example, when the advisors both say an event is “likely,” participants will say that it is “very likely.” This effect occurs for both probabilities above and below 50%, for hypothetical scenarios and real events, and when presenting the others’ forecasts simultaneously or sequentially. We also show that this combination strategy carries over to subsequent consumer decisions that rely on advisors’ likelihood judgments. We discuss and rule out several candidate mechanisms for our effect. This paper was accepted by Yuval Rottenstreich, decision analysis.
Efficient demodulation scheme based on adaptive clock extraction and
mapping-sampling for a mobile OCC system
Authors: Huang Zheng , He Jing , Yu Ke , Li Wei 
Published: March 2021

An efficient demodulation scheme based on adaptive clock extraction and mapping-sampling is proposed and experimentally demonstrated for mobile optical camera communication (OCC) systems. For the proposed scheme, it can effectively improve the system performance in mobile OCC. The bit error rate (BER) performance of the proposed scheme and the other existing schemes are compared. The experimental results show that under the speed from 0.4 m/s to 0.7 m/s, it can significantly improve the system performance using the adaptive clock extraction and the mapping-sampling scheme in mobile OCC systems. Compared with the length estimation scheme, when the speed is 0.7 m/s, the BER can be improved from

9.14

×

10

−
2

to

3.16

×

10

−
4

at the exposure time of 1/12,000 s using the proposed scheme. In addition, the required memory and processing time of the proposed scheme are analyzed, which indicates that the proposed scheme has negligible influence on memory overhead and computational complexity.
The PCOC Symptom Assessment Scale (SAS): A valid measure for daily use at point of care and in palliative care programs
Authors: Daveson Barbara A. , Allingham Samuel Frederic , Clapham Sabina , Johnson Claire E. , Currow David C. , Yates Patsy , Eagar Kathy 
Published: March 2021

Background
Very few measures are used successfully as part of routine care within national palliative care outcome programs. Only a handful of studies examine these measures. The aim of this study is to evaluate the validity of a measure used in a national outcomes program: the Palliative Care Outcomes Collaboration Symptom Assessment Scale (PCOC SAS).

Methods
A retrospective multi-site cohort study with secondary analysis of routinely collected patient-level data to assess PCOC SAS’s internal consistency, construct validity, reliability, interpretability, acceptability and sensitivity. The analyses used two sets, with data collected by inpatient and community palliative care services registered with the Australian national PCOC.

Results
Dataset one included 1,117 patients receiving palliative care from 21 services. Dataset two included 5,294 patients receiving palliative care from 119 PCOC services. PCOC SAS demonstrated the ability to detect and discriminate distress by palliative care phase, functional status and diagnosis. Excellent and good convergent and discriminant validity were demonstrated. Fair through to substantial inter-rater and intra-rater reliability levels were evidenced. Sufficient interpretability resulted along with necessary levels of acceptability and sensitivity.

Conclusion
PCOC SAS is a valid and reliable patient-reported outcome measure suitable for use in routine clinical care with patients requiring palliative and or end-of-life care, including in national outcomes programs.
A randomised trial examining inflammatory signaling in acutely induced hyperinsulinemia and hyperlipidemia in normal weight women-the reprometabolic syndrome
Authors: Tannous Andrew , Bradford Andrew P. , Kuhn Katherine , Fought Angela , Schauer Irene , Santoro Nanette 
Published: March 2021

Context
Obesity, is a state of chronic inflammation, characterized by elevated lipids, insulin resistance and relative hypogonadotropic hypogonadism. We have defined the accompanying decreased Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), ovarian steroids and reduced pituitary response to Gonadotropin-releasing Hormone (GnRH) as Reprometabolic syndrome, a phenotype that can be induced in healthy normal weight women (NWW) by acute infusion of free fatty acids and insulin.

Objective
To identify potential mediators of insulin and lipid-related reproductive endocrine dysfunction.

Design, setting, participants
Secondary analysis of crossover study of eumenorrheic reproductive aged women of normal Body Mass Index (BMI) (<25 kg/m2) at an academic medical center.

Intervention
Participants underwent 6-hour infusions of either saline/heparin or insulin plus fatty acids (Intralipid plus heparin), in the early follicular phase of sequential menstrual cycles, in random order. Euglycemia was maintained by glucose infusion. Frequent blood samples were obtained.

Main outcome measures
Pooled serum from each woman was analyzed for cytokines, interleukins, chemokines, adipokines, Fibroblast Growth Factor-21 (FGF-21) and markers of endoplasmic reticulum (ER) stress (CHOP and GRP78). Wilcoxon signed-rank tests were used to compare results across experimental conditions.

Results
Except for Macrophage Inflammatory Protein-1β (MIP-1β), no significant differences were observed in serum levels of any of the inflammatory signaling or ER stress markers tested.

Conclusion
Acute infusion of lipid and insulin, to mimic the metabolic syndrome of obesity, was not associated with an increase in inflammatory markers. These results imply that the endocrine disruption and adverse reproductive outcomes of obesity are not a consequence of the ambient inflammatory environment but may be mediated by direct lipotoxic effects on the hypothalamic-pituitary-ovarian (HPO) axis.