bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Sistem Informasi Sekolah Kejuruan dengan Menggunakan Metode Waterfall (Studi Kasus SMK PGRI 1 Kota Serang-Banten)
Authors: Irwanto Irwanto 
Published: February 2021

Pengembangan sistem informasi ini bertujuan untuk menghasilkan suatu sistem layanan informasi di SMK PGRI 1 Kota Serang sebagai sistem dan sumber informasi yang layak. Teknologi informasi digunakan sebagai sarana, baik kegiatan non akademis maupun akademis. Pemanfaatan internet untuk penyampaian informasi belum di terapkan di SMK PGR1 Kota Serang. Sistem informasi sekolah berbasis website merupakan solusi dan objek dari penelitian ini.Penelitian yang digunakan adalah penelitian Research and Deveopment (R&D) dengan model pengembangannya waterfall yang terdiri dari 4 (empat) tahap yaitu Analisis, Desain, Pengodean dan Pengujian. Model pengembangan menggunakan waterfall atau juga disebut (air terjun) ini sering juga disebut model sekuensial linier (sequential linear) atau disebut juga alur hidup klasik (classic life cycle). Teknik pengambilan data yang digunakan yaitu wawancara dengan wakil bidang kurikulum SMK PGRI 1 Kota Serang, observasi, uji coba ke 30 responden serta 2 orang ahli media. Hasil penelitian yang didapat adalah nilai skor rata-rata validasi ahli media yang didapatkan sebesar 72,5 dengan kategori sangat layak. Adapun hasil dari pengguna didapatkan skor nilai sebesar 71,96 dengan kategori sangat layak. Jadi dapat disimpulkan bahwa perancangan sistem informasi sekolah kejuruan dapat dikembangkan dengan menggunakan metode penelitian dan pengembangan, dengan model waterfall dengan tahapan-tahapan penelitian diantaranya yaitu analisis, desain, pemrograman dan pengujian. Proses pembuatan sistem informasi sekolah diantaranya membuat flowchart dan storyboard, menetapkan dan menyusun konten, merancang proses alur sistem informasi sekolah berdasarkan dengan susunan konten yang sudah dibuat dengan bantuan aplikasi sublime text editor.
Louis Jullien
Authors: McLeod Jillian 
Published: February 2021

Well known for his extravagant appearance, Louis Jullien (1812-1860), a prominent conductor in England, programmed concerts that were entertaining and accessible to the public. During the nineteenth century, conductors began to take responsibility for the artistic and musical direction of their concerts. Jullien’s concerts included dance, choral, and classical music to appeal to a variety of tastes. His theatricality on the podium and use of a baton captivated his audiences, while his distinctive conducting personality contributed to the visual appeal of the concert experience. Audience members and musical reviewers alike were attracted to the spectacular display at Jullien’s concerts.
Through the examination of articles in the Musical World, the most important London-based music periodical published in Jullien’s time, and Romantic orchestral scholarship, this research investigates Louis Jullien’s role as a conducting figure. While Adam Carse has described the biographical accounts of Jullien’s life and Holly Mathieson has examined the artistic representations of Jullien and has interpreted his conducting as militaristic and magical, scholars have not yet examined the sublime in the reception of Jullien’s performance. Jullien’s virtuosic self presentation and performance behaviour inspired responses that drew upon the language of the sublime and influenced how he was received as a visionary figure. His status as a visionary was further developed by his innovations as a conductor.
A STUDY ON POTENTIAL DRUG-DRUG INTERACTIONS AMONG PATIENTS ADMITTED UNDER DEPARTMENT OF MEDICINE IN A TERTIARY CARE HOSPITAL IN INDIA
Authors: Bandyopadhyay Sanjib , Mitra Kaushik , Bhaumik Dipankar , Das Saibal 
Published: February 2021

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India.
Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used.
Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs.
Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed.
Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.
PATHOPHYSIOLOGY, TYPES, ITS MEDIATORS & TREATMENT STRATEGIES OF ALZHEIMER’S DISEASE: A SHORT REVIEW
Authors: Singh Puneet , Sharma Yogesh , Sharma Ashutosh 
Published: February 2021

Cognition in an extensive sense means information dispensation. It denotes a relatively high level of processing of definite information including thinking, memory, perception, incentive, skilled arrangements and language. Learning is the most attribute attributes of the man and also of higher animals. Learning is definite as the skill to alter behavior on the basis of understanding. We know that some reminiscences last for only a few seconds, whereas others last for hours, days, months or year. Dementia is generally defined as the loss of logical abilities (medically called cognitive dysfunction) of sufficient capacity to interfere with social or occupational functioning. People with DLB have some of the symptoms common in Alzheimer’s, but are more likely than people with Alzheimer’s to have initial or early symptoms such as sleep disturbances, well-formed visual hallucinations, and muscle rigidity or other parkinsonian movement features. The signature lesions in AD are neuritic plaques and neurofibrillary tangles (NFTs) to be found in the cortical areas and medial temporal lobe structures of the brain.
Keywords: Alzheimer, Neurofibrillary tangles, Neuritic plaques, Dementia, Temporal lobe
ENVIRONMENTAL EDUCATION AND AWARENESS TO PROTECT EGYPTIAN TORTOISE (TESTUDO KLEINMANNI) BY LOCAL COMMUNITY PARTICIPATION
Authors: Buijlayyil Murad , Kiraz Aşkın 
Published: February 2021

This research has examined the effectiveness of education and environmental awareness of the local population in protecting Egyptian tortoises. The study aimed to obtain information about the relationship between the level of education, monthly income and its relationship to tortoise protection and the prevention of smuggling and illegal trade. The results were obtained through the preparation of a questionnaire that included 40 people from the local population. They were surveyed using the SPSS26 program. According to the results obtained by the research, significant differences were found in the environmental attitudes of the local population who did not have a chance to have a good education and their monthly income was very low. It could be said that the people who got a good opportunity for education and their economic situation is stable, this has a positive impact on their environmental behaviour.
Keywords: environmental education, environmental awareness, Egyptian tortoise
METAPHOR ANALYSIS OF THE PERCEPTIONS OF "GLOBAL WARMING" AS A CONCEPT
Authors: Üretici Pelin 
Published: February 2021

The environmental problem, defined as "global warming" in recent years, has developed as a result of human activities. This problem affects humanity with its economic, social and cultural dimensions as well as many other living species. Policies​ are being developed at national and international levels to cope with this problem and various opinions and practices are put forward. However, studies show that individuals have misconceptions about this issue. For this purpose, this study aims to understand the perceptions of 87 participants, 65 women and 22 men living in the TRNC, about global warming through a "metaphor analysis". The study was conducted using a qualitative phenomenology design. The data obtained were evaluated by content analysis method. Semi-structured forms were distributed for data collection. The first part of the form is based on demographic information, and the second part is to determine the perceptions of the participants about global warming. The analyzed metaphors were gathered under 13 different conceptual categories. Since this study does not consist of an equal number of male and female participants, gender differences should not be taken into account in the findings.
Keywords: Global warming, environmental management, metaphor analysis, environmental education
PENGEMBANGAN PERANGKAT PEMBELAJARAN CIRC (COOPERATIVE INTEGRATED READING AND COMPOSITION) DALAM MENINGKATKAN PEMAHAMAN MATEMATIS PADA MATERI PERBANDINGAN SISWA SMP
Authors: Mulyadin Edi , Sowanto Sowanto , Dusalan Dusalan 
Published: February 2021

Penelitian ini bertujuan untuk: (1) menghasilkan perangkat pembelajaran dengan model pembelajaran CIRC guna meningkatkan pemahaman siswa yang layak digunakan dalam proses pembelajaran, dan (2) mengetahui kualitas dan respon siswa terhadap perangkat pembelajaran yang telah dikembangkan dan digunakan dalam proses pembelajaran. Penelitian ini merupakan penelitian pengembangan (Research and Development) dengan model Ploomp. Subjek uji coba lapangan meliputi 30 siswa kelas VIII-7 di SMP Negeri 1 Kota Bima. Instrument yang digunakan berupa lembar validasi untuk validator (3 orang guru matematika di SMP Negeri 1 Kota Bima), lembar angket respon siswa, serta lembar observasi berupa angket soal analisis bagi siswa. Data kualitas produk yang diperoleh dari validator dianalisis dengan menggunakan analisis deskriptif, yaitu mengolah skor rata-rata aspek kualitas yang diperoleh dari nilai kuantitatif menjadi nilai kualitatif menggunakan kriteria kategori penilaian ideal. Hasil penilaian terhadap produk berupa draf RPP, LKS dan Model Pembelajaran siswa menggunakan analisis data berupa pengolahan secara kuantitatif dan kualitatif. Penilaian dilakukan dengan mencari nilai rata-rata dari semua aspek penilaian prototipe oleh validator adalah 4,8 dengan kriteria kualitatif sangat valid. Sedangkan penilaian dari 30 siswa memiliki rata-rata nilai sebesar 33,93% dengan kriteria kualitatif cukup dengan presentase keidealan sebesar 50,88%. Data ini menunjukkan bahwa produk draf RPP, LKS dan Modul Pembelajaran Siswa yang dikembangkan dengan model pembelajaran CIRC dapat diaplikasikan di SMP Negeri 1 Kota Bima.
Anticoagulant Activity of Dayak Onion Bulb (Eleutherine bulbosa) Extract on Human Blood Samples
Authors: Handayati Anik , Arifin Syamsul , Astuti Monica Putji 
Published: February 2021

Cardiovascular disease can occur due to disruption of the hemostatic system by forming blood clots in blood vessels, or commonly known as deep vein thrombosis. The curative action that has been carried out in the form of heparin anticoagulant administration had many side effects such as bleeding, hematuria, thrombocytopenia, and hypersensitivity; therefore, alternative anticoagulant ingredients such as onion bulbs have emerged. Dayak onion bulb (Eleutherine bulbosa) is known to contain eleutherinol compound, which has anticoagulant activity. This study aims to determine the potential anticoagulant activity of Dayak onion bulbs extract (Eleutherine bulbosa) on human blood samples. This anticoagulant activity test was carried out by observing the length of time for blood clotting in the extract treatment group with several concentrations (0, 10, 12.5, 16, 25, and 50%) by Clotting Time (Lee-White) method. The results showed a significant delay in blood coagulation time in the group treated with Dayak onion bulbs extract as increasing the concentration. About 50% Dayak onion onion bulb extract was showed a twofold increase in blood coagulation time thanthat of no extract administration. So that, Dayak bulb onion has the opportunity to be an alternative natural anticoagulant.
Keywords: anticoagulants; Dayak onion bulbs (Eleutherine bulbosa); clotting time
Isolation and Multiple Differentiation of Rat Pericardial Fluid Cells
Authors: Sun Ying , Wang Yan , Li Zongjin , Guo Zhikun 
Published: February 2021

ObjectiveThe aim of the present study is to isolate and analyze the characterization of pericardial fluid cells (PFCs) from rat and provides a morphological basis for the basic research and clinical application of PFCs.MethodsAfter aseptic thoracotomy was performed, normal saline was injected into the pericardial cavity of 50 adult Sprague–Dawley rats. The mixture of diluted pericardial fluid was extracted, centrifuged, and cultured. The cell morphology of different generations in the pericardial fluid was observed on an inverted microscope. The expression levels of CD44, CD29, CD90, and pan-hematopoietic marker CD45 were analyzed via flow cytometry. The third-generation cells were used for osteogenic, adipogenic, and cardiac differentiation.ResultsPFCs were successfully isolated and subcultured. PFCs were predominantly circular in shape after 24 h of culture. Following subculture for 3 days, the cells demonstrated a spindle shape. The rat pericardial fluid contains cell populations with uniform morphology, good growth state, and strong proliferation ability. Flow cytometry results showed that CD29 (100%) and CD90 (99.3%) were positively expressed, whereas CD45 (0.30%) and CD44 (0.48%) were negatively expressed. The PFCs could differentiate into osteoblasts and adipocytes after being induced. Cardiac differentiation was also confirmed by cardiac troponin T (cTnT) and α-sarcomeric actin (α-SA) staining.ConclusionThis study revealed that a subpopulation of cells was isolated from pericardial fluid, which exhibited progenitor cell features and multiple differentiation potency. PFCs could serve as an alternative cell source for myocardial tissue repair, engineering, and reconstruction.
Lactobacillus-Depleted Vaginal Microbiota in Pregnant Women Living With HIV-1 Infection Are Associated With Increased Local Inflammation and Preterm Birth
Authors: Short Charlotte-Eve S. , Brown Richard G. , Quinlan Rachael , Lee Yun S. , Smith Ann , Marchesi Julian R. , Shattock Robin , Bennett Phillip R. , Taylor Graham P. , MacIntyre David A. 
Published: February 2021

BackgroundPregnant women living with HIV-1 infection (PWLWH) have an elevated risk of preterm birth (PTB) of unknown aetiology, which remains after successful suppression of HIV. Women at high risk for HIV have a common bacterial profile which has been associated with poor birth outcomes. We set out to explore factors associated with gestational age at delivery of PWLWH in a UK population.MethodsProspective study of PWLWH (n = 53) in whom the vaginal microbiota and cervicovaginal cytokine milieu were assessed using metataxonomics and multiplexed immunoassays, respectively. Cross-sectional characterisation of vaginal microbiota in PWLWH were compared with 22 HIV uninfected pregnant women (HUPW) at a similar second trimester timepoint. Within PWLWH the relationships between bacterial composition, inflammatory response, and gestational age at delivery were explored.FindingsThere was a high rate of PTB among PWLWH (12%). In the second trimester the vaginal microbiota was more diverse in PWLWH than in HUPW (Inverse Simpson Index, p = 0.0004 and Species Observed, p = 0.009). PWLWH had a lower prevalence of L. crispatus dominant vaginal microbiota group (VMB I, 15 vs 54%) than HUPW and higher prevalence of L. iners dominant (VMB III, 36 vs 9% and VMB IIIB, 15 vs 5%) and mixed anaerobes (VMB IV, 21 vs 0%). Across the second and third trimesters in PWLWH, VMB III/IIIB and IV were associated with PTB and with increased local inflammation [cervicovaginal fluid (CVF) cytokine concentrations in upper quartile]. High bacterial diversity and anaerobic bacterial abundance were also associated with CVF pro-inflammatory cytokines, most notably IL-1β.InterpretationThere is an association between local inflammation, vaginal dysbiosis and PTB in PWLWH. Understanding the potential of antiretroviral therapies to influence this cascade will be important to improve birth outcomes in this population.
Determining the Risk of Developing Rheumatic Heart Disease Following a Negative Screening Echocardiogram
Authors: Zimmerman Meghan , Scheel Amy , DeWyer Alyssa , Nambogo Jane-Liz , Otim Isaac Omara , Tompsett Alison , Rwebembera Joselyn , Okello Emmy , Sable Craig , Beaton Andrea 
Published: February 2021

Background: Screening echocardiograms can detect early-stage rheumatic heart disease (RHD), offering a chance to limit progression. Implementation of screening programs is challenging and requires further research. This is the first large-scale study assessing the risk of RHD among previous screen-negative children.Methods: This retrospective cohort study, conducted in Gulu, Uganda, performed school-based echo screening on children ages 5–18 years. Surveys were used to determine which children underwent initial screening 3–5 years prior. Age, gender, and disease severity were compared between cohorts. Relative risk (RR) of RHD was calculated for those with a prior screen-negative echo (exposed cohort) compared to those undergoing first screening (unexposed cohort).Results: Echo screening was completed in 75,708 children; 226 were excluded, leaving 1,582 in the exposed cohort and 73,900 in the unexposed cohort. Prevalence of new RHD was 0.6% (10/1,582) and 1% (737/73,900), in the exposed and unexposed cohorts, respectively. The RR of RHD was 0.64 (95% CI 0.3–1.2, p = 0.15), a nearly 40% reduced risk of RHD in those with a prior negative echo. There was no difference in age or gender between RHD cohorts. All cases in the exposed cohort were borderline/mild; 2.6% of cases in the unexposed cohort had moderate/severe disease.Conclusion: There was no statistical difference in RHD prevalence between previous screen-negative children and children with no prior echocardiogram, however, there was a trend toward decreased risk and severity. This information has important implications for the design of screening programs and the use of screening echocardiograms in endemic RHD regions.
Stratigraphic Architecture of the Karoo River Channels at the End-Capitanian
Authors: Bordy Emese M. , Paiva Francisco 
Published: February 2021

The main Karoo Basin of southern Africa contains the continental record of the end-Triassic, end-Permian, and end-Capitanian mass extinction events. Of these, the environmental drivers of the end-Capitanian are least known. Integrating quantitative stratigraphic architecture analysis from abundant outcrop profiles, paleocurrent measurements, and petrography, this study investigates the stratigraphic interval that records the end-Capitanian extinction event in the southwestern and southern main Karoo Basin and demonstrates that this biotic change coincided with a subtle variation in the stratigraphic architectural style ∼260 Ma ago. Our multi-proxy sedimentological work not only defines the depositional setting of the succession as a megafan system that drained the foothills of the Cape Fold Belt, but also attempts to differentiate the tectonic and climatic controls on the fluvial architecture of this paleontologically important Permian succession. Our results reveal limited changes in sediment sources, paleocurrents, sandstone body geometries, and possibly a constant hot, semi-arid paleoclimate during the deposition of the studied interval; however, the stratigraphic trends show upward increase in 1) laterally accreted, sandy architectural elements and 2) architectural elements that build a portion of the floodplain deposits. We consider this to reflect a long-term retrogradational stacking pattern of facies composition that can be linked to changes on the medial parts of southward draining megafans, where channel sinuosity increased, and depositional energy decreased at the end-Capitanian. The shift in the fluvial architecture was likely triggered by basin-wide allogenic controls rather than local autogenic processes because this trend is observed in the coeval stratigraphic intervals from geographically disparate areas in the southwestern and southern main Karoo Basin. Consequently, we propose that this regional backstepping most likely resulted from tectonic events in the adjacent Cape Fold Belt.
Strong-Motions From Damaging Moderate Magnitude (5.9 ≥ Mw) Earthquakes in Japan Recorded by K-NET and KiK-net
Authors: Dhakal Yadab P. 
Published: February 2021

Strong-motions from 79 moderate magnitude (5.9 ≥ Mw) earthquakes that caused various degrees of impact on humans and built-environment in Japan between 1996 and 2019, after the start of K-NET and KiK-net, are presented. As such, most of the earthquakes occurred beneath the land, and agencies had reported damages from events as small as Mw 4.1. Together, large peak ground accelerations exceeding 500 cm/s2were recorded during 15 earthquakes, reaching approximately 1128 cm/s2during one event. Similarly, large peak ground velocities exceeding 30 cm/s were recorded during ten earthquakes, reaching about 76 cm/s to the maximum. Most of the large values aforementioned were recorded within a hypocentral distance of approximately 30 km and on soil site conditions. Intermediate to long-period ground motions are of growing concerns in urban areas located on sedimentary basins with mid-rise and high-rise buildings. The threshold magnitude for the large ground motions at the periods of about 2–5 s is not well understood. In March 2013, the Japan Meteorological Agency introduced four levels of long-period ground motion intensity (LPGMI) based on absolute velocity response spectra (AVRS) between 1.6 and 7.8 s. In the present data set, LPGMI of level 3 (AVRS 50–100 cm/s) and level 4 (AVRS &gt;100 cm/s) were observed each at a single site from shallow-focus earthquakes of Mw 5.8 and 5.9 at distances of approximately 12 and 15 km, respectively. However, the peak response periods were relatively short (1.6–1.8 s). The data showed that LPGM from moderate earthquakes is of lower concern regarding earthquake early warning at distances beyond 200 km. The 2018 Mw 5.5 North Osaka earthquake, despite the moderate magnitude, caused the loss of six human lives and brought significant damage to buildings and lifelines. Comparing the data with the ground motion prediction equations (GMPEs) and other events suggested that the North Osaka earthquake was probably a higher stress drop event. These moderate earthquakes’ observations hinted that the commonly used GMPEs in Japan may not sufficiently grasp these earthquakes' hazards.