bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study of α-Hemihydrate Preparation from Phosphogypsum Before and After Flotation Purification
Authors: Du Mingxia , Wang Jinming , Dong Faqin , Wang Zhaojia , Yang Feihua , Tan Hongbin , Fu Kaibin , Wang Weiqing 
Published: September 2021

Abstract
Phosphogypsum (PG) is a massive industrial solid waste. In this paper, PG was purified by flotation method, and α-hemihydrate gypsum (α-HH) was prepared by the autoclaving method. The morphology of α-HH was adjusted by adding different doses of Maleic acid and Aluminium sulfate. The results showed that after flotation purification, the impurity content in PG was significantly reduced, the soluble phosphorus content decreased from 0.48% to 0.07%, the PG purity increased from 73.12% to 94.37%, and the PG whiteness risen from 19.4 to 40.5. Then the performance of α-HH prepared from PG before and after purification was compared. Fixing the amount of Aluminium sulfate at 0.2wt%, the reaction temperature at 140°C, and the reaction time at 120min, the average length/diameter ratio of α-HH crystals decreased from 7.2 to 0.6 as the amount of Maleic acid increased from 0 to 0.17wt%. When the amount of Maleic acid was 0.13wt%, the α-hemihydrate gypsum reached the best mechanical properties. The mechanical strength of high strength gypsum prepared from PG concentrate was significantly better than that of raw PG, indicating that flotation purification can effectively improve the performance of PG. In this study, a new method of PG purification and resource utilization was proposed.
Three-Hourly versus Two-Hourly Feeding Interval in Stable Preterm Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Kumar Jogender , Meena Jitendra , Debata Pradeep , Sankar Jeeva Mary , Kumar Praveen , Shenoi Arvind 
Published: September 2021

Abstract
Evidence from randomized controlled trials (RCTs) suggests that three-hourly feeding is safe and might help achieve full feeds earlier in preterm infants. We systematically compared the benefits and harms of three-hourly and two-hourly feeding schedules in preterm infants. We searched electronic databases (MEDLINE, CINAHL, Embase, Web of Science, and Scopus) and trial registries until 30 July 2021 for RCTs comparing the two feeding schedules. We did random-effects meta-analysis using RevMan 5.4 software. The primary outcome was the incidence of stage II or III necrotizing enterocolitis (NEC). Other outcomes were the incidence of any stage NEC, sepsis, mortality, time to full enteral feeds, and hospital stay. Six trials (872 participants) are included. There was no significant difference in the incidence of stage II/III NEC (3 trials; 530 participants; RR 1.39; 95% CI: 0.53,3.65; I2 -0%, low certainty), and any stage NEC (5 studies; 767 participants; RR 0.98; 95% CI: 0.53,1.82; I2 0%, very-low certainty) between three and two-hourly feeding groups. There was no difference in the time to achieve full feeds (5 trials; 755 participants; MD: -0.0 days; 95% CI: -0.32, 0.31, low certainty) or other outcomes. On subgroup analysis, neonates with birthweight <1000 grams and in the three-hourly feeding regime achieved full enteral feeds slower than those in the two-hourly feeding group (1 trial; 84 participants; MD: 2.9 days, 95% CI: 1.16, 4.64, low certainty).ConclusionIn stable preterm infants (1000-1500 grams), three-hourly feeding can be followed safely. In infants <1000 grams, two-hourly feeding should be continued till further evidence.Prospero Registration Number: CRD42021246568
Long-term Results of Ulnar and Radial Reconstruction With Interpositional Grafting Using the Deep Inferior Epigastric Artery for Chronic Hand Ischemia
Authors: Ahn Hee Chang , Oh Se Won , Yoon Jung Soo , Park Seong Oh 
Published: September 2021

Abstract
Chronic hand ischemia causes cold intolerance, intractable pain, and digital ulceration. If ischemic symptoms persist despite pharmacologic treatments, surgical interventions should be considered. This retrospective study evaluated long-term results after ulnar and radial reconstruction using an interpositional deep inferior epigastric artery (DIEA) graft combined with periarterial sympathectomy. Patients who underwent this surgery from March 2003 to February 2019 were included. To evaluate variables influencing recurrence after the procedure, patients were divided into recurred and non-recurred groups and compared. Overall, 62 cases involving 47 patients were analyzed, with 16 and 46 cases in the recurred and non-recurred groups, respectively. The median length of DIEA grafts was 8.5 cm. Rates of rheumatic disease and female patients were significantly higher in the recurred group than in the non-recurred group, without significant between-group differences in postoperative complication rates. In the multivariate analysis, underlying rheumatic disease and graft length had significant effects on recurrence. In the Kaplan-Meier analysis, the 5- and 10-year symptom-free rates were 81.3% and 68.0%, respectively, with lower rates for cases with rheumatic disease. Thus, arterial reconstruction using an interpositional DIEA graft provides long-term sustainable vascular supply in chronic hand ischemia patients, especially those without rheumatic disease.
Biomechanical Comparison of Lag Screw and Non-spiral Blade Fixation of a Novel Femoral Trochanteric Nail in an Osteoporotic Bone Model
Authors: Fuse Yoshifumi , Zenke Yukichi , Okimoto Nobukazu , Yoshioka Toru , Yamanaka Yoshiaki , Kawasaki Makoto , Terayama Hiroshi , Sakai Akinori 
Published: September 2021

Abstract
PurposeThere is no consensus regarding the advantages of the lag screw type over the blade type for treating femoral trochanteric fractures. We aimed to investigate whether non-spiral blade (Conventional-Blade, Fid-Blade) nails provide better biomechanical fixation than lag screws in a severe osteoporotic bone model.MethodsDifferent severities of osteoporotic cancellous bone were modelled using polyurethane foam blocks of three densities (0.24, 0.16, and 0.08 g/cm3). Three torsional tests were performed using each component for each bone density and the maximum torque was recorded, and the energy required to achieve 30° rotation was calculated. Using a push-in test, the maximum force was recorded, and the energy required to achieve 4-mm displacement was calculated. ResultsFor 0.08-g/cm3 density, the peak torques to achieve 30° rotation, energy required to achieve 30° rotation, peak force to achieve 4-mm displacement, and energy required to achieve 4-mm displacement were significantly greater for Conventional-Blade and Fid-Blade than for Lag Screw. ConclusionsConventional-Blade and Fid-Blade nails exhibited significantly higher values than Lag Screw under any test condition. The blade-type nail component may have a better fixation capability than the lag screw type in a severe osteoporotic bone model.
Fabrication of ZnO nanocatalyst as an excellent heterogeneous catalyst applicant for Methyl Orange dye degradation in aqueous medium.
Authors: Mahar Zaheer Ahmed , Shar Ghulam Qadir , Balouch Aamna 
Published: September 2021

Abstract
The current paper describes the fabrication of an excellent and economical heterogeneous nanocatalyst for the degradation of methyl orange dye in aqueous medium. ZnO/PVP nanocatalyst has been successfully synthesized by the chemical degradation route, followed by ultrasonication. The size, shape and crystalline structure of synthesized ZnO/PVP nano composite was characterized by UV-visible spectroscopy, X-ray diffractometry, Dynamic Scattering Light, Zeta Potential, Fourier transform infrared spectroscopy, Scanning Electron Microscope, Energy Dispersive X-ray and X-ray photoelectron spectroscopy. To authenticate the catalytic efficiency of nanocatalyst, the fabricated ZnO/PVP nanocompoiste was screened for methyl orange dye degradation. Finally, synthesized nanocatalyst exhibited an admirable catalytic efficiency, above 98% of methyl orange degradation observed just in 90 seconds using least catalyst dose (150μg) in aqueous medium. The engineered ZnO/PVA nanocomposite shows several advantages over traditional methods for the degradation of hazard and toxic dyes, such as high percentage degradation, short time and minimum dose of nano catalyst and excellent reusability. It is suggested that this rare nanocatalyst may be used successfully on commercial level for degradation toxic pollutants.
Water vapor and CMAS corrosion tests of Si/Y2SiO5 Thermal and Environmental Barrier Coating
Authors: Zhang Qi , Zhang Xueqin , Ma Zhuang , Liu Ling , Liu Yanbo , Zheng Wei 
Published: September 2021

Abstract
Thermal and environmental barrier coating (TEBC), the up-to-date concept, is introduced to protect silicon-based ceramics matrix composites (CMC) from not only high temperature water vapor but also the alkali salt from volcanic ash and dust suspending in atmosphere. Because both of high temperature steam and CMAS will make Si-based CMC deteriorate rapidly. By executing the corrosion test against high temperature water vapor, we find that Si/Y2SiO5 double-layer TEBC can effectively protect SiCf/SiC CMC from water vapor at 1300 ℃ for over 205 hours. Almost all Y2SiO5 transform into Y4.67(SiO4)3O after corrosion test. It is also found that in CMAS corrosion test, the reaction zone formed between CMAS and Y2SiO5 layer prevents the mutual diffusion of elements in CMAS and Y2SiO5 layer. The apparent activation energy of reaction between CMAS and Y2SiO5 in 1200~1300℃ temperature ranges is calculated to be 713.749kJ/mol. These findings provide a reference to select appropriate materials for TEBC.
Coffee consumption and the risk of polycystic ovary syndrome: evidence from a case-control study
Authors: Wang Yue , Yang Yin , Deng Hui , Bu Xiao-Qing , Li Tian , Zhong Zhao-Hui , Tang Xiao-Jun , Feng Qian , Ding Yu-Bin , Fu Li-Juan 
Published: September 2021

Abstract
Background

Coffee has become one of the most common beverages worldwide. Some components in coffee have been reported to be beneficial to the regulation of hormones related to polycystic ovary syndrome(PCOS), and therefore may limit the development of PCOS. However, epidemiological evidence on the relationship between coffee consumption and PCOS is limited. In this study, we aimed at investigating the association between coffee consumption and PCOS risk.
Methods

The study was a hospital-based case-control study conducted at Chongqing Hospital of Traditional Chinese Medicine, China, from July 2018 to January 2020. Data was collected from 206 women with PCOS and 206 healthy women. A self-designed structured questionnaire was employed to collect relevant information from study participants. Sleep quality was evaluated by Pittsburgh Sleep Quality Index (PSQI). Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CI), adjusted for other confounding factors.
Results

A statistically significant inverse correlation was observed between coffee consumption and PCOS. After adjusting all potential confounding factors, the results of logistic regression analysis showed that compared to non-drinker, the ORs(95%CI) for ≤ 1 cup/week, 2–3 cups/week and > 3 cups/week were 0.322(0.180–0.574), 0.263(0.104–0.664) and 0.152(0.046–0.563), respectively, and the linear trend was also statistically significant(P for trend < 0.01).
Conclusions

Coffee consumption was found to be associated with a reduced risk of PCOS. Given the scarcity of studies on coffee consumption and PCOS, as well as the inherent limitations of our study, the prospective cohort studies in the future are needed to verify our results.
Prevalence and factors associated with utilisation of postnatal care in Sierra Leone: a 2019 national survey
Authors: Sserwanja Quraish , Nuwabaine Lilian , Kamara Kassim , Musaba Milton W 
Published: September 2021

Abstract
Background
Globally, about 289,000 maternal deaths are registered annually. Timely access to quality maternal health services is an effective intervention to reduce maternal deaths. Postnatal care (PNC) is one of the recommended packages in the continuum of maternity care aimed at reducing maternal and neonatal mortality. This study aimed to determine the prevalence and factors associated with PNC utilisation in Sierra Leone.
Methods
We used Sierra Leone Demographic and Health Survey (UDHS) 2019 data of 7,326 women aged 15 to 49 years. We conducted multivariable logistic regression to determine the factors associated with PNC utilisation, using SPSS version 25.
Results
Out of 7,326 women, 3,329 (45.5%, 95% CI: 44.6–46.8) had their babies have at least a PNC contact, 6,646 (90.7%, 95% CI: 90.2–91.5) had a postnatal check after childbirth and 3,133 (42.8%, 95% CI: 41.9–44.1) had PNC for both their babies and themselves. Delivery by caesarean section (aOR 1.79, 95% CI: 1.20–2.67), having a visit by a health field worker (aOR 1.77, 95% CI: 1.47–2.13), having had eight or more ANC contacts (aOR 1.79, 95% CI: 1.45–2.22), initiating ANC after first trimester (aOR 1.18, 95% CI: 1.04–1.35), being a Muslim (aOR 1.34, 95% CI: 1.11–1.61), belonging to richer wealth quintile (aOR 1.69, 95% CI: 1.22–2.35), being of low parity (2–4) (aOR 1.20, 95% CI: 1.04–1.39), having no big problems seeking permission to access healthcare (aOR 1.52, 95% CI: 1.27–1.83) and having had delivery at home (aOR 1.75, 95% CI: 1.32–2.32) were associated with more PNC utilisation odds. On the other hand, being resident in the Eastern region (aOR 0.31, 95% CI: 0.21–0.46) and urban areas (aOR 0.71, 95% CI: 0.52–0.98) were associated with lower odds of utilising PNC.
Conclusion
Although maternal PNC utilisation is high, utilisation of PNC by neonates alone and by both the mother and neonatal is low. More focus is needed to mothers and their neonates from the Eastern region, urban areas, Christians, less empowered in terms of healthcare seeking decision making and those who are more parous, utilise less ANC contacts and utilise health facilities for delivery.
Massed Strandings of Whales and Dolphins – Effects of Wind, Waves and Tides.
Authors: Baines Peter , Day Robert 
Published: September 2021

Abstract
We examined125 mass-stranding events of cetaceans (>=10 individuals) on New Zealand shores over the past 40 years. The wind, waves, wave refraction, shore slopes and tides at the dates and locations of these events were considered. The mass-strandings involved 10 different species, but by far the most common involved the Long-finned Pilot Whale, Globicephala melas. Our hypothesis is that mass-stranding is a three-stage process. The first stage is when an animal becomes ill, its body may become bloated and float on the surface, and the wind and waves may drive it ashore. We assume the second stage is that the dying or dead body may be accompanied by pod members as a result of strong social bonds. The third stage involves the tides and the beach slope. If these are of sufficient amplitude, the nearby attendees will quickly become stranded in the intertidal of a gently sloping beach as the water level falls. We have evaluated evidence for the first and third stages. In the overwhelming majority (91%) of the mass-strandings (omitting events inside estuaries), the available data showed that wind and waves would drive floating objects (bodies) toward the stranding site. Examination of the nearshore slopes and the tide ranges showed that the vast majority of the stranding sites were slowly shelving beaches where the tides would retreat rapidly over 10s of metres. These 2 results are even more pronounced if only Pilot Whale mass strandings are considered.
SIRT3 Inhibits Cholangiocarcinoma Cell Proliferation by Targeting HIF1α to regulate the EMT Signaling Pathway
Authors: Zhao Yihang , Kuai Yaxian , Xu Jianhua , Cui Yufang , Wu Juan , Zhang Mingming , Xu Lei , Zhou Lixing , Sun Bin , Li Yang 
Published: September 2021

Abstract
BackgroundCholangiocarcinoma (CCA), is a rare biliary adenocarcinoma associated with poor outcomes. Deacetylase Sirtuin‐3 (SIRT3), a histone deacetylase (HDAC), has been considered to be associated with various cancers and can be a potential new target for CCA.We intended to identify the target of SIRT3 and explore the mechanism of SIRT3 in CCA.MethodsThe expression levels of SIRT3 and hypoxia‐inducible factor‐1α (HIF1α) in CCA tissues and cell lines were examined by RT-qPCR. CCK-8 and EdU methods were used to detect cell proliferation in CCA. To assess the levels of proteins related to cell proliferation and epithelial-mesenchymal transition (EMT) process, western blot analysis was conducted. Co-Immunoprecipitation and deacetylation assays were used to explore HIF1α protein acetylation, stability and the relationship between SIRT3 and HIF1α in CCA cells.ResultsSIRT3 showed low expression in CCA tissues and cells. SIRT3 overexpression inhibited cell proliferation and EMT process. Moreover, the interaction between SIRT3 and HIF1α was confirmed and HIF1α expression was negatively regulated by SIRT3. Furthermore, we also found that HIF1α was more easily degraded and showed a reduction in stability through deacetylation via SIRT3 knockdown. In rescue assays, HIF1α also reversed the inhibitory effect of SIRT3 on cell proliferation and the EMT process. ConclusionsSIRT3 suppressed cell proliferation and the EMT process in CCA by targeting HIF1α.Trial registrationSamples were obtained only after the patient has given informed consent according to the established plan approved by the Ethics Committee of The First Affiliated Hospital of Anhui Medical University.
Investigation of the Genetic Structure of Some Common Bean (Phaseolus vulgaris L.) Commercial Varieties and Genotypes Used as a Genitor with SSR and SNP markers
Authors: AVICAN Omer , Bilgen Behiye Banu 
Published: September 2021

Abstract
Common bean is a species belonging to the Phaseolus genus of the Leguminosae family. It has economic importance due to being rich in protein, vitamin A and C, and minerals. Being one of the most cultivated species of legumes, the determination of genetic diversity in bean genotypes or populations has an important role in terms of our genetic resources. The objective of this study was to evaluate the genetic structure of 94 genotypes which were cultivated in different parts of the world and our country with SSR and SNP markers. 10 SSR loci and 73 SNP primers were used for the determination of genetic structure in commercial cultivars and breeding lines. All of the SSR and SNP loci used in the study were found to be polymorphic. A total of 89 alleles were identified for 10 SSR loci. Mean number of alleles per locus (Na=8.9), effective allele number (Ne=3.731), Shannon information index (I=1.468), observed heterozygosity (Ho=0.023), and expected heterozygosity (He=0.654) were calculated based on SSR analysis. According to the results of Bayesian-based STRUCTURE analysis using SSR and SNP data, 94 bean genotypes were genetically divided into three main clusters. According to genetic similarity based UPGMA dendrogram obtained from SSR and SNP analysis, 94 bean genotypes were divided into 2 main clusters. The obtained results provide important information about the genetic structures of the studied bean cultivars and breeding lines. With the obtained results, it will be possible to develop breeding programs to develop new cultivars by using our gene resources.
How do pandemics end? Two decades of recurrent outbreak risk following the main waves
Authors: Schroeder Max , Lazarakis Spyridon , Mancy Rebecca , Angelopoulos Konstantinos 
Published: September 2021

Abstract

We analyse the dynamic evolution of disease outbreak risk after the main waves of the 1918-19 “Spanish flu” pandemic in the US and in major cities in the UK, and after the 1890-91 “Russian flu” pandemic in England and Wales. We compile municipal public health records and use national data to model the stochastic process of mortality rates after the main pandemic waves as a sequence of bounded Pareto distributions with an exponentially decaying tail parameter. In all cases, we find elevated mortality risk lasting nearly two decades. An application to COVID-19 under model uncertainty shows that in 90% of model-predicted time series, the annual probability of outbreaks exceeding 500 deaths per million is above 20% for a decade, remaining above 10% for two decades.
In-Depth Benchmarking of DIA-type Proteomics Data Analysis Strategies Using a Large-Scale Benchmark Dataset Comprising Inter-Patient Heterogeneity
Authors: Fröhlich Klemens , Brombacher Eva , Fahrner Matthias , Vogele Daniel , Kook Lucas , Bronsert Peter , Timme Sylvia , Schmidt Alexander , Baerenfaller Katja , Kreutz Clemens , Schilling Oliver 
Published: September 2021

Abstract
An overwhelming number of proteomics software tools and algorithms have been published for different steps of Data Independent Acquisition analysis of clinical samples. Nonetheless, there is still a lack of comprehensive benchmark studies evaluating which combinations of those isolated components perform best.Here, we used 92 lymph nodes from distinct patients to create a unique benchmark dataset representing real-world inter-individual heterogeneity. The publicly available dataset comprises 118 LC-MS/MS runs with > 12 million MS2 spectra and allowed us to objectively evaluate how well different combinations of spectral libraries, DIA software, sparsity reduction, normalization and statistical tests can detect differentially abundant proteins, while also taking sample size into account.Evaluation of 2 million data analysis workflows showed that a gas phase fractionation refined spectral library in combination with DIA-NN and Significance Analysis of Microarrays reliably detected differentially abundant proteins. Furthermore, DIA-NN and Spectronaut robustly avoided the false detection of truly absent proteins.*KF and EB share first authorship. CK and OS share last authorship.