bluuebunny/crossref_metadata_2025_split huggingface dataset:
A transcriptional hub integrating gibberellin–brassinosteroid signals to promote seed germination in Arabidopsis
Authors: Zhong Chunmei , Patra Barunava , Tang Yi , Li Xukun , Yuan Ling , Wang Xiaojing 
Published: April 2021

AbstractSeed germination is regulated by multiple phytohormones, including gibberellins (GAs) and brassinosteroids (BRs); however, the molecular mechanism underlying GA and BR co-induced seed germination is not well elucidated. We demonstrated that BRs induce seed germination through promoting testa and endosperm rupture in Arabidopsis. BRs promote cell elongation, rather than cell division, at the hypocotyl–radicle transition region of the embryonic axis during endosperm rupture. Two key basic helix–loop–helix transcription factors in the BR signaling pathway, HBI1 and BEE2, are involved in the regulation of endosperm rupture. Expression of HBI1 and BEE2 was induced in response to BR and GA treatment. In addition, HBI1- or BEE2-overexpressing Arabidopsis plants are less sensitive to the BR biosynthesis inhibitor, brassinazole, and the GA biosynthesis inhibitor, paclobutrazol. HBI1 and BEE2 promote endosperm rupture and seed germination by directly regulating the GA-Stimulated Arabidopsis 6 (GASA6) gene. Expression of GASA6 was altered in Arabidopsis overexpressing HBI1, BEE2, or SRDX-repressor forms of the two transcription factors. In addition, HBI1 interacts with BEE2 to synergistically activate GASA6 expression. Our findings define a new role for GASA6 in GA and BR signaling and reveal a regulatory module that controls GA and BR co-induced seed germination in Arabidopsis.
Strategic calculations? Partisan differences in support for Puerto Rican migration to the mainland USA
Authors: Whitaker Beth Elise ,   and, Giersch Jason 
Published: April 2021

Abstract
Building on research about political determinants of migration attitudes, this study examines whether public opinion is influenced by the potential political participation of migrants themselves. We use the opportunity presented by the recent increase in the number of US citizens moving from Puerto Rico to the mainland to investigate how partisanship and political calculations shape attitudes toward their migration. Using data from an online survey experiment in early 2020, we find partisan differences in support for Puerto Rican migration. Democrats were significantly more likely than Republicans and independents to support Puerto Rican migration to the mainland in the aftermath of recent natural disasters, while Republicans were more likely to support Puerto Ricans returning home for the rebuilding process. The partisan divide was exacerbated when respondents were given additional information about the voting eligibility of Puerto Ricans and the possibility that their votes could help a Democratic presidential candidate win the state of Florida in the 2020 election. Specifically, Republicans who received this information were significantly less likely than all other respondents, including Republicans in the control group, to support Puerto Rican migration to the mainland USA. Findings on several related variables also show significant partisan differences, though treatment effects are less pronounced. Although further research is necessary to determine whether similar patterns hold in situations where migrants are not immediately eligible to vote or perceived as supporting one side, this study provides initial evidence that strategic partisan calculations can influence attitudes toward migration in a competitive political context.
Sarcoidosis Presenting as Dorsal Wrist Mass: A Case Report
Authors: Kim Gabriel , Banks Willie , Sadr Bahman , Paal Edina , Martin Jabari 
Published: April 2021

ABSTRACTPatients with sarcoidosis have an indolent course in which the disease is not detected unless seemingly benign symptoms appear. Such was the case in a 42-year-old man who was referred to the orthopedic service for evaluation of a slowly enlarging mass over the left wrist without prior history of trauma. In this article, we will review the symptoms and histopathology of sarcoidosis with a particular focus on orthopedic manifestations of the disease. We believe that clinicians should be aware of these associations so that patients can be diagnosed and treated accordingly.
Forward modelling of Kepler-band variability due to faculae and spots
Authors: Johnson Luke J , Norris Charlotte M , Unruh Yvonne C , Solanki Sami K , Krivova Natalie , Witzke Veronika , Shapiro Alexander I 
Published: April 2021

ABSTRACT
Variability observed in photometric light curves of late-type stars (on time-scales longer than a day) is a dominant noise source in exoplanet surveys and results predominantly from surface manifestations of stellar magnetic activity, namely faculae and spots. The implementation of faculae in light-curve models is an open problem, with scaling typically based on spectra equivalent to hot stellar atmospheres or assuming a solar-derived facular contrast. We modelled rotational (single period) light curves of active G2, K0, M0, and M2 stars, with Sun-like surface distributions and realistic limb-dependent contrasts for faculae and spots. The sensitivity of light-curve variability to changes in model parameters such as stellar inclination, feature area coverage, spot temperature, facular region magnetic flux density, and active band latitudes is explored. For our light-curve modelling approach we used actress, a geometrically accurate model for stellar variability. actress generates two-sphere maps representing stellar surfaces and populates them with user-prescribed spot and facular region distributions. From this, light curves can be calculated at any inclination. Quiet star limb darkening and limb-dependent facular contrasts were derived from MURaM 3D magnetoconvection simulations using ATLAS9. 1D stellar atmosphere models were used for the spot contrasts. We applied actress in Monte Carlo simulations, calculating light-curve variability amplitudes in the Kepler band. We found that, for a given spectral type and stellar inclination, spot temperature and spot area coverage have the largest effect on variability of all simulation parameters. For a spot coverage of $1{{\ \rm per\ cent}}$, the typical variability of a solar-type star is around 2 parts per thousand. The presence of faculae clearly affects the mean brightness and light-curve shape, but has relatively little influence on the variability.
SDSS-IV MaNGA: enhanced star formation in galactic-scale outflows
Authors: Bao Min , Chen Yanmei , Yuan Qirong , Shi Yong , Bizyaev Dmitry , Yu Xiaoling , Feng Shuai , Cao Xiao , Gao Yulong , Gu Qiusheng , Yu Ying 
Published: April 2021

ABSTRACT
Using the integral field unit (IFU) data from Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, we collect a sample of 36 star-forming galaxies that host galactic-scale outflows in ionized gas phase. The control sample is matched in the three-dimensional parameter space of stellar mass, star formation rate, and inclination angle. Concerning the global properties, the outflows host galaxies tend to have smaller size, more asymmetric gas disc, more active star formation in the centre, and older stellar population than the control galaxies. Comparing the stellar population properties along axes, we conclude that the star formation in the outflows host galaxies can be divided into two branches. One branch evolves following the inside-out formation scenario. The other located in the galactic centre is triggered by gas accretion or galaxy interaction, and further drives the galactic-scale outflows. Besides, the enhanced star formation and metallicity along minor axis of outflows host galaxies uncover the positive feedback and metal entrainment in the galactic-scale outflows. Observational data in different phases with higher spatial resolution are needed to reveal the influence of galactic-scale outflows on the star formation progress in detail.
An X-ray and radio study of the Hubble Frontier Field cluster Abell S1063
Authors: Rahaman Majidul , Raja Ramij , Datta Abhirup , Burns Jack O , Alden Brian , Rapetti David 
Published: April 2021

ABSTRACT
We present results from Chandra X-ray observations and 325 MHz Giant Metrewave Radio Telescope (GMRT) observations of the massive and X-ray luminous cluster of galaxies Abell S1063. We report the detection of large-scale ‘excess brightness’ in the residual Chandra X-ray surface brightness map that extends at least 2.7 Mpc towards the north-east from the centre of the cluster. We also present a high fidelity X-ray flux and temperature map using Chandra archival data of 122 ks that shows the disturbed morphology in the cluster. The residual flux map shows the first observational confirmation of the merging axis proposed in earlier simulations. The average temperature within R500 is 11.7 ± 0.56 keV that makes AS1063 one of the hottest clusters in the nearby Universe. The integrated radio flux density at 325 MHz is found to be 62.0 ± 6.3 mJy. The integrated spectrum of the radio halo follows a power law with a spectral index α = −1.43 ± 0.13. The radio halo is found to be significantly under-luminous that favored for both the hadronic as well as the turbulent re-acceleration mechanism for its origin.
Gene Duplication and Loss ofAANATin Mammals Driven by Rhythmic Adaptations
Authors: Yin Daiqing , Zhou RuRu , Yin Mengxin , Chen Yue , Xu Shixia , Yang Guang 
Published: April 2021

AbstractArylalkylamine N-acetyltransferase (AANAT) plays a crucial role in synchronizing internal biological functions to circadian and circannual changes. Generally speaking, only one copy of AANAT gene has been found in mammals, however, three independent duplications of this gene were detected in several cetartiodactyl lineages (i.e., Suidae, Hippopotamidae, and Pecora), which originated in the middle Eocene, a geological period characterized with the increased climate seasonality. Lineage-specific expansions of AANAT and the associated functional enhancement in these lineages strongly suggest an improvement in regulating photoperiodic response to adapt to seasonal climate changes. In contrast, independent inactivating mutations or deletions of the AANAT locus were identified in the four pineal-deficient clades (cetaceans, sirenians, xenarthrans, and pangolins). Loss of AANAT function in cetaceans and sirenians could disrupt the sleep-promoting effects of pineal melatonin, which might contribute to increasing wakefulness, adapting these clades to underwater sleep. The absence of AANAT and pineal glands in xenarthrans and pangolins may be associated with their body temperature maintenance. The present work demonstrates a far more complex and intriguing evolutionary pattern and functional diversity of mammalian AANAT genes than previously thought and provides further evidence for understanding AANAT evolution as driven by rhythmic adaptations in mammals.
The Dockstore: enhancing a community platform for sharing reproducible and accessible computational protocols
Authors: Yuen Denis , Cabansay Louise , Duncan Andrew , Luu Gary , Hogue Gregory , Overbeck Charles , Perez Natalie , Shands Walt , Steinberg David , Reid Chaz , Olunwa Nneka , Hansen Richard , Sheets Elizabeth , O’Farrell Ash , Cullion Kim , O’Connor Brian D , Paten Benedict , Stein Lincoln 
Published: April 2021

Abstract
Dockstore (https://dockstore.org/) is an open source platform for publishing, sharing, and finding bioinformatics tools and workflows. The platform has facilitated large-scale biomedical research collaborations by using cloud technologies to increase the Findability, Accessibility, Interoperability and Reusability (FAIR) of computational resources, thereby promoting the reproducibility of complex bioinformatics analyses. Dockstore supports a variety of source repositories, analysis frameworks, and language technologies to provide a seamless publishing platform for authors to create a centralized catalogue of scientific software. The ready-to-use packaging of hundreds of tools and workflows, combined with the implementation of interoperability standards, enables users to launch analyses across multiple environments. Dockstore is widely used, more than twenty-five high-profile organizations share analysis collections through the platform in a variety of workflow languages, including the Broad Institute's GATK best practice and COVID-19 workflows (WDL), nf-core workflows (Nextflow), the Intergalactic Workflow Commission tools (Galaxy), and workflows from Seven Bridges (CWL) to highlight just a few. Here we describe the improvements made over the last four years, including the expansion of system integrations supporting authors, the addition of collaboration features and analysis platform integrations supporting users, and other enhancements that improve the overall scientific reproducibility of Dockstore content.
Distal renal tubular acidosis: ERKNet/ESPN clinical practice points
Authors: Trepiccione Francesco , Walsh Steven B , Ariceta Gema , Boyer Olivia , Emma Francesco , Camilla Roberta , Ferraro Pietro Manuel , Haffner Dieter , Konrad Martin , Levtchenko Elena , Lopez-Garcia Sergio Camilo , Santos Fernando , Stabouli Stella , Szczepanska Maria , Tasic Velibor , Topaloglu Rezan , Vargas-Poussou Rosa , Wlodkowski Tanja , Bockenhauer Detlef 
Published: April 2021

AbstractDistal renal tubular acidosis (dRTA) is characterized by an impaired ability of the distal tubule to excrete acid, leading to metabolic acidosis. Associated complications include bone disease, growth failure, urolithiasis and hypokalaemia. Due to its rarity, there is limited evidence to guide diagnosis and management; however, available data strongly suggest that metabolic control of the acidosis by alkali supplementation can halt or revert almost all complications. Despite this, cohort studies show that adequate metabolic control is present in only about half of patients, highlighting problems with treatment provision or adherence. With these clinical practice points the authors, part of the working groups tubulopathies in the European Rare Kidney Disease Reference network and inherited kidney diseases of the European Society for Paediatric Nephrology, aim to provide guidance for the management of patients with dRTA to facilitate adequate treatment and establish an initial best practice standard against which treatment of patients can be audited.
The challenge of early diagnosis of autoimmune lymphoproliferative syndrome in children with suspected autoinflammatory/autoimmune disorders
Authors: Oliveira Mendonça Leonardo , Matucci-Cerinic , Caterina , Terranova , Paola , Casabona Federica , Bovis Francesca , Caorsi Roberta , Fioredda Francesca , Palmisani Elena , Grossi Alice , Guardo Daniela , Bustaffa Marta , Volpi Stefano , Ceccherini Isabella , Ravelli Angelo , Dufour Carlo , Miano Maurizio , Gattorno Marco 
Published: April 2021

Abstract

Objectives
To test the usefulness of an extended panel of lymphocyte subsets in combination with Oliveira’s diagnostic criteria for the identification of autoimmune lymphoproliferative syndrome (ALPS) in children referred to a paediatric rheumatology centre.

Methods
Patients referred from 2015 to 2018 to our rheumatology unit for an autoimmune or autoinflammatory condition were retrospectively analysed. Oliveira’s required criteria [chronic lymphoproliferation and elevated double-negative T (DNT)] were applied as first screening. Flow cytometry study included double-negative CD4–CD8–TCRαβ+ T lymphocytes (DNT), CD25+CD3+, HLA–DR+CD3+ T cells, B220+ T cells and CD27+ B cells. Data were analysed with a univariate logistic regression analysis, followed by a multivariate analysis. Sensitivity and specificity of the Oliveira’s required criteria were calculated.

Results
A total of 264 patients were included in the study and classified as: (i) autoimmune diseases (n = 26); (ii) juvenile idiopathic arthritis (JIA) (35); (iii) monogenic systemic autoinflammatory disease (27); (iv) periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (100); (v) systemic undefined recurrent fever (45); (vi) undetermined-systemic autoinflammatory disease (14); or (vii) ALPS (17). Oliveira’s required criteria displayed a sensitivity of 100% and specificity of 79%. When compared with other diseases the TCRαβ+B220+ lymphocytes were significantly increased in ALPS patients. The multivariate analysis revealed five clinical/laboratory parameters positively associated to ALPS: splenomegaly, female gender, arthralgia, elevated DNT and TCRαβ+B220+ lymphocytes.

Conclusions
Oliveira’s required criteria are useful for the early suspicion of ALPS. TCRαβ+B220+ lymphocytes should be added in the diagnostic work-up of patients referred to the paediatric rheumatology unit for a suspected autoimmune or autoinflammatory condition, providing a relevant support in the early diagnosis of ALPS.
Autoantibody predictors of gastrointestinal symptoms in systemic sclerosis
Authors: Ahmed Fiza , Maclean Rory H , Nihtyanova Svetlana I , Ong Voon H , Murray Charles D , Denton Christopher P 
Published: April 2021

Abstract

Objectives
To assess the prevalence and burden of SSc-related gastrointestinal dysfunction (SSc-GI) and to evaluate associations with demographic, clinical and serological characteristics.

Methods
Patients completed the UCLA SCTC GIT 2.0 questionnaire for SSc-GI disease to assess the burden of GI disease across multiple functional and psychological domains. Questionnaire scores were assessed using non-parametric and quantile regression analyses.

Results
Our cohort included 526 patients with SSc, with a typical distribution of disease-associated autoantibodies (ACA, ARA, ATA, PM-Scl, U1RNP, U3RNP). We demonstrated associations between hallmark antibodies and the domain-specific burden of GI disease. In particular, ACA, ARA and ENA-negative demonstrated increased SSc-GI disease burden, while PM-Scl conferred relative protection. In a distributional analysis, associations with autoantibodies were particularly marked in those with the highest burden of GI disease.

Conclusion
There is a significant burden of SSc-GI disease in patients with SSc; reflux and bloating symptoms are most prominent. SSc hallmark antibodies may predict increased risk of SSc-GI disease, in particular ACA and ARA, while PM-Scl may be protective.
Mapping the ‘funny bone’: neuroanatomical correlates of humor creativity in professional comedians
Authors: Brawer Jacob , Amir Ori 
Published: April 2021

AbstractWhat are the neuroanatomical correlates of expertise in a specific creative domain? Professional comedians, amateurs and controls underwent a T1 MRI anatomical scan. Measures of cortical surface area (gyrification and sulcal depth) and thickness were extracted for each participant. Compared to controls, professional comedians had a greater cortical surface area in the left inferior temporal gyrus, angular gyrus, precuneus and right medial prefrontal cortex. These regions have been previously implicated in abstract, divergent thinking and the default-mode network. The high degree of overlap between the regions of greater surface area in professional comedians with the regions showing greater activation in the same group during comedy improvisation in our previous work (particularly the temporal regions and angular gyrus) suggests that these regions may be specifically involved in humor creativity.
Spatial divisions of poverty and wealth: does segregation affect educational achievement?
Authors: Otero Gabriel , Carranza Rafael , Contreras Dante 
Published: April 2021

AbstractWe examine how different spatial compositions affect the educational achievement in mathematics of 16-year-old students in Chile, a Latin American country with high inequality and one of the most segregated education systems in the world. Conceptually, we complement the literature on ‘neighbourhood effects’, which typically addresses the influence of concentrated disadvantage, by focusing on concentrated advantage and its influence on educational outcomes. We construct a panel with all school students who took a national standardized mathematics test in 2010, 2014 and 2016 in the Metropolitan Region of Santiago, Chile. We complement it with survey data for the 52 districts of the Metropolitan Region, clustering the districts based on factors such as unemployment, economic inequality, access to services, experiences of violence and stigmatization. Our different identification strategies consistently show that concentrated poverty and affluence are both relevant for explaining educational achievement in mathematics above and beyond individual and school characteristics.
Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study
Authors: Krishnamoorthy Vijay , Manley Geoffrey T. , Jain Sonia , Sun Shelly , Foreman Brandon , Komisarow Jordan , Laskowitz Daniel T. , Mathew Joseph P. , Hernandez Adrian , James Michael L. , Vavilala Monica S. , Markowitz Amy J. , Korley Frederick K. ,   the TRACK-TBI Investigators
Published: April 2021

Background:
Traumatic brain injury (TBI) is a major global health problem. Little research has addressed extracranial organ dysfunction following TBI, particularly myocardial injury. Using a sensitive marker of myocardial injury—high sensitivity troponin (hsTn)—we examined the incidence of early myocardial injury following TBI and explored its association with neurological outcomes following moderate-severe TBI.

Methods:
We conducted a pilot cohort study of 133 adult (age above 17 y) subjects enrolled in the TRACK-TBI 18-center prospective cohort study. Descriptive statistics were used to examine the incidence of myocardial injury (defined as hsTn >99th percentile for a standardized reference population) across TBI severities, and to explore the association of myocardial injury with a 6-month extended Glasgow Outcome Score among patients with moderate-severe TBI.

Results:
The mean (SD) age of the participants was 44 (17) years, and 87 (65%) were male. Twenty-six patients (20%) developed myocardial injury following TBI; myocardial injury was present in 15% of mild TBI patients and 29% of moderate-severe TBI patients (P=0.13). Median (interquartile range) hsTn values were 3.8 ng/L (2.1, 9.0), 5.8 ng/L (4.5, 34.6), and 10.2 ng/L (3.0, 34.0) in mild, moderate, and severe TBI participants, respectively (P=0.04). Overall, 11% of participants with moderate-severe TBI and myocardial injury experienced a good outcome (6-mo extended Glasgow Outcome Score≥5) at 6 months, compared with 65% in the group that did not experience myocardial injury (P=0.01).

Conclusions:
Myocardial injury is common following TBI, with a likely dose-response relationship with TBI severity. Early myocardial injury was associated with poor 6-month clinical outcomes following moderate-severe TBI.
DDIT4 mediates the proliferation-promotive effect of IL-34 in human monocytic leukemia cells
Authors: Lv Xiaoqian , Hu Yuting , Wang Lina , Zhang Dongyue , Wang Hao , Dai Yibo , Cui Xiaoxi , Zheng Guoguang 
Published: April 2021

Abstract

Interleukin 34 (IL-34) is a cytokine that shares the receptor with colony-stimulating factor 1 (CSF-1). IL-34 is involved in a broad range of pathologic processes including cancer. We previously demonstrated that IL-34 promoted the proliferation and colony formation of human acute monocytic leukemia (AMoL) cells. However, the mechanism has not been elucidated. Here, by analyzing the gene profiles of Molm13 and THP1 cells overexpressing IL-34 (Molm13-IL-34 and THP1-IL-34), upregulation of the DNA damage-inducible transcript 4 (DDIT4) was detected in both series. Knockdown of DDIT4 effectively inhibited the proliferation, promoted apoptosis and colony formation in Molm13-IL-34 and THP1-IL-34 cells. Our results suggest that DDIT4 mediates the proliferation-promotive effect of IL-34 whereas does not mediate the promotive effect of IL-34 on colony formation in AMoL cells.