bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary complications observed in patients with infective endocarditis with and without injection drug use: An analysis of the National Inpatient Sample
Authors: Bui Jenny T. , Schranz Asher J. , Strassle Paula D. , Agala Chris B. , Mody Gita N. , Ikonomidis John S. , Long Jason M. 
Published: September 2021

Background
The impact of cardiovascular and neurologic complications on infective endocarditis (IE) are well studied, yet the prevalence and significance of pulmonary complications in IE is not defined. To better characterize the multifaceted nature of IE management, we aimed to describe the occurrence and significance of pulmonary complications in IE, including among persons with IE related to drug use.

Methods
Hospitalizations of adult (≥18 years old) patients diagnosed with IE were identified in the 2016 National Inpatient Sample using ICD-10 codes. Multivariable logistic and linear regression were used to compare IE patient outcomes between those with and without pulmonary complications and to identify predictors of pulmonary complications. Interaction terms were used to assess the impact of drug-use IE (DU-IE) and pulmonary complications on inpatient outcomes.

Results
In 2016, there were an estimated 88,995 hospitalizations of patients diagnosed with IE. Of these hospitalizations,15,490 (17%) were drug-use related. Drug-use IE (DU-IE) had the highest odds of pulmonary complications (OR 2.97, 95% CI 2.50, 3.45). At least one pulmonary complication was identified in 6,580 (7%) of IE patients. DU-IE hospitalizations were more likely to have a diagnosis of pyothorax (3% vs. 1%, p<0.001), lung abscess (3% vs. <1%, p<0.001), and septic pulmonary embolism (27% vs. 2%, p<0.001). Pulmonary complications were associated with longer average lengths of stay (CIE 7.22 days 95% CI 6.11, 8.32), higher hospital charges (CIE 78.51 thousand dollars 95% CI 57.44, 99.57), more frequent post-discharge transfers (acute care: OR 1.37, 95% CI 1.09, 1.71; long-term care: OR 2.19, 95% CI 1.83, 2.61), and increased odds of inpatient mortality (OR 1.81 95% CI 1.39, 2.35).

Conclusion and relevance
IE with pulmonary complications is associated with worse outcomes. Patients with DU-IE have a particularly high prevalence of pulmonary complications that may require timely thoracic surgical intervention, likely owing to right-sided valve involvement. More research is needed to determine optimal management strategies for complications to improve patient outcomes.
Effects of different ischemic preconditioning strategies on physiological and cellular mechanisms of intestinal ischemia/reperfusion injury: Implication from an isolated perfused rat small intestine model
Authors: Wong Yuk Lung , Lautenschläger Ingmar , Hummitzsch Lars , Zitta Karina , Cossais François , Wedel Thilo , Rusch Rene , Berndt Rouven , Gruenewald Matthias , Weiler Norbert , Steinfath Markus , Albrecht Martin 
Published: September 2021

Background
Intestinal ischemia/reperfusion (I/R)-injury often results in sepsis and organ failure and is of major importance in the clinic. A potential strategy to reduce I/R-injury is the application of ischemic preconditioning (IPC) during which repeated, brief episodes of I/R are applied. The aim of this study was to evaluate physiological and cellular effects of intestinal I/R-injury and to compare the influence of in-vivo IPC (iIPC) with ex-vivo IPC (eIPC), in which blood derived factors and nerval regulations are excluded.

Methods
Using an established perfused rat intestine model, effects of iIPC and eIPC on physiological as well as cellular mechanisms of I/R-injury (60 min hypoxia, 30 min reperfusion) were investigated. iIPC was applied by three reversible occlusions of the mesenteric artery in-vivo for 5 min followed by 5 min of reperfusion before isolating the small intestine, eIPC was induced by stopping the vascular perfusion ex-vivo 3 times for 5 min followed by 5 min of reperfusion after isolation of the intestine. Study groups (each N = 8–9 animals) were: iIPC, eIPC, I/R (iIPC group), I/R (eIPC group), iIPC+I/R, eIPC+I/R, no intervention/control (iIPC group), no intervention/control (eIPC group). Tissue morphology/damage, metabolic functions, fluid shifts and barrier permeability were evaluated. Cellular mechanisms were investigated using signaling arrays.

Results
I/R-injury decreased intestinal galactose uptake (iIPC group: p<0.001), increased vascular perfusion pressure (iIPC group: p<0.001; eIPC group: p<0.01) and attenuated venous flow (iIPC group: p<0.05) while lactate-to-pyruvate ratio (iIPC group, eIPC group: p<0.001), luminal flow (iIPC group: p<0.001; eIPC group: p<0.05), goblet cell ratio (iIPC group, eIPC group: p<0.001) and apoptosis (iIPC group, eIPC group: p<0.05) were all increased. Application of iIPC prior to I/R increased vascular galactose uptake (P<0.05) while eIPC had no significant impact on parameters of I/R-injury. On cellular level, I/R-injury resulted in a reduction of the phosphorylation of several MAPK signaling molecules. Application of iIPC prior to I/R increased phosphorylation of JNK2 and p38δ while eIPC enhanced CREB and GSK-3α/β phosphorylation.

Conclusion
Intestinal I/R-injury is associated with major physiological and cellular changes. However, the overall influence of the two different IPC strategies on the acute phase of intestinal I/R-injury is rather limited.
Development of ACE2 autoantibodies after SARS-CoV-2 infection
Authors: Arthur John M. , Forrest J. Craig , Boehme Karl W. , Kennedy Joshua L. , Owens Shana , Herzog Christian , Liu Juan , Harville Terry O. 
Published: September 2021

Background
Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of the AT1 receptor and decreased immune system activation. We hypothesized that autoantibodies against ACE2 may develop after SARS-CoV-2 infection, as anti-idiotypic antibodies to anti-spike protein antibodies.

Methods and findings
We tested plasma or serum for ACE2 antibodies in 67 patients with known SARS-CoV-2 infection and 13 with no history of infection. None of the 13 patients without history of SARS-CoV-2 infection and 1 of the 20 outpatients that had a positive PCR test for SARS-CoV-2 had levels of ACE2 antibodies above the cutoff threshold. In contrast, 26/32 (81%) in the convalescent group and 14/15 (93%) of patients acutely hospitalized had detectable ACE2 antibodies. Plasma from patients with antibodies against ACE2 had less soluble ACE2 activity in plasma but similar amounts of ACE2 protein compared to patients without ACE2 antibodies. We measured the capacity of the samples to inhibit ACE2 enzyme activity. Addition of plasma from patients with ACE2 antibodies led to decreased activity of an exogenous preparation of ACE2 compared to patients that did not have antibodies.

Conclusions
Many patients with a history of SARS-CoV-2 infection have antibodies specific for ACE2. Patients with ACE2 antibodies have lower activity of soluble ACE2 in plasma. Plasma from these patients also inhibits exogenous ACE2 activity. These findings are consistent with the hypothesis that ACE2 antibodies develop after SARS-CoV-2 infection and decrease ACE2 activity. This could lead to an increase in the abundance of Ang II, which causes a proinflammatory state that triggers symptoms of PASC.
Los spots electorales en las primeras campañas multipartidistas españolas: la personalización de la política como valor estratégico
Authors: Gil-Torres Alicia , Cáneba Rocío Asencio , De la Rosa Cristina San José 
Published: September 2021

La primacía de la televisión e internet como nuevo medio de comunicación han hecho que los anuncios continúen teniendo importancia durante las campañas electorales. El trabajo aborda el vacío existente de la literatura del estudio de la publicidad electoral en el marco de las primeras elecciones generales multipartidistas del 20D de 2015. Ante la incapacidad de formar gobierno por parte de los cuatro partidos mayoritarios en España: PP, PSOE, Podemos y Ciudadanos, se repitieron los comicios el 26J de 2016.
Los objetivos se centran en la tipología de spots utilizada y el uso de la publicidad negativa mediante un análisis descriptivo de una muestra de 77 spots recopilados de las cuentas oficiales de YouTube. Cobra vital importancia la personalización de la política y la imagen que la publicidad hace de los candidatos. De igual manera, la metodología se establece como punto de partida para un análisis de los spots creados para posteriores campañas electorales en España, subsanando así el vacío académico existente.
Seroprevalence and associated risk factors of avian influenza virus subtype H9N2 in backyard poultry of Peshawar Pakistan
Authors: Rehman S. , Khan M. I. , Rantam F. A. , Effendi M. H. , Shehzad A. , Tariq A. 
Published: September 2021

The current study was conducted to estimate the serological prevalence and risk factors associated with the transmission of avian influenza subtype H9N2 among backyard poultry from different villages of semi-arid climate district Peshawar Pakistan between January to May 2019. In total, 240 blood samples of healthy backyard poultry older than two months were collected from 30 different villages of district Peshawar. A predesigned questionnaire was used to collect the data related to risk factors. Se-rum samples were tested through the haemagglutination inhibition (HI) test further confirmed by the micro-neutralizing test (MN). Antibody body titer ≤ 8 considered negative for prevalence of H9N2. In order to classify risk factors, Chi-square and Logistic regression analyses were performed. Out of 240, 150 were found to be positive. The overall seroprevalence was 62.5%, mean antibody titer for avian influenza virus in all villages was 6.8 and (95%) confidence interval ranges from 35.33 to 51.70% re-spectively. The high prevalence of antibodies to avian influenza viruses in bird serum emphasizes that avian influenza plays an important role in the respiratory infections of backyard chickens in the area, and possibly throughout Pakistan. In order to avoid the introduction of H9N2, biosecurity initiatives, surveillance, monitoring systems, and to some extent, vaccinations are useful tools.
Präteritumschwund im Deutschen
Authors: Fischer Hanna 
Published: September 2021

Abstract
The loss of the preterite form in German dialects is still a disputed and unresolved matter. The article summarizes the results of a new study that analyzes several dialectological documentations (e. g. dialect grammars, dialect atlases) and recognizes the areal distribution of the loss of the preterite as a threefold scale (number of preterite building verbs, frequency of forms, hierarchy in loss of forms). On this basis the article reconstructs the historical process of the loss of the preterite and suggests an integrative explanation of the described process as the result of the semantic and functional expansion of the German present perfect.
Three-dimensional transient electromagnetic inversion with optimal transport
Authors: Sun Xiaomeng , Wang Yanfei , Yang Xiao , Wang Yibo 
Published: September 2021

Abstract
Transient electromagnetic method (TEM), as one of the essential time-domain electromagnetic prospecting approaches, has the advantage of expedition, efficiency and convenience. In this paper, we study the transient electromagnetic inversion problem of different geological anomalies. First, Maxwell’s differential equations are discretized by the staggered finite-difference (FD) method; then we propose to solve the TEM inversion problem by minimizing the Wasserstein metric, which is related to the optimal transport (OT). Experimental tests based on the layered model and a 3D model are performed to demonstrate the feasibility of our proposed method.
Physical exercise in pregnancy: benefits, risks and prescription
Authors: Ribeiro Maria Margarida , Andrade Ana , Nunes Inês 
Published: September 2021

Abstract

Objectives
The aim of this article is to provide a comprehensive literature review, gathering the strongest evidence about the risks and benefits and the prescription of physical exercise during pregnancy.

Content
Regular physical exercise during pregnancy is associated with numerous benefits. In general women are not adequately advised on this matter. Along with their concerns regarding the potential associated risks, it contributes to the abandonment or refusal to start exercising during pregnancy. A systematic review was conducted in MEDLINE including articles considered to have the highest level of scientific evidence. Fifty-seven articles, including 32 meta-analysis, 9 systematic reviews and 16 randomized controlled trials were included in the final literature review.

Summary
Exercise can help preventing relevant pregnancy related disorders, such as gestational diabetes, excessive gestational weight gain, hypertensive disorders, urinary incontinence, fetal macrosomia, lumbopelvic pain, anxiety and prenatal depression. Exercise is not related with an increased risk of maternal or perinatal adverse outcomes. Compliance with current guidelines is sufficient to achieve the main benefits, and exercise type and intensity should be based on woman’s previous fitness level.

Outlook
Exercise in pregnancy is safe for both mother and fetus, contributing to prevent pregnancy related disorders. Exercise type and intensity should be adapted to woman’s previous fitness level, medical history and characteristics of the ongoing pregnancy.
Awareness of maternal stress, consequences for the offspring and the need for early interventions to increase stress resilience
Authors: Arabin Birgit , Hellmeyer Lars , Maul Johanna , Metz Gerlinde A.S. 
Published: September 2021

Abstract
Experimental and clinical studies suggest that prenatal experiences may influence health trajectories up to adulthood and high age. According to the hypothesis of developmental origins of health and disease exposure of pregnant women to stress, nutritional challenges, infection, violence, or war may “program” risks for diseases in later life. Stress and anxieties can exist or be provoked in parents after fertility treatment, after information or diagnosis of fetal abnormalities and demand simultaneous caring concepts to support the parents. In vulnerable groups, it is therefore important to increase the stress resilience to avoid harmful consequences for the growing child. “Enriched environment” defines a key paradigm to decipher how interactions between genes and environment change the structure and function of the brain. The regulation of the fetal hippocampal neurogenesis and morphology during pregnancy is one example of this complex interaction. Animal experiments have demonstrated that an enriched environment can revert consequences of stress in the offspring during critical periods of brain plasticity. Epigenetic markers of stress or wellbeing during pregnancy might even be diagnosed by fragments of placental DNA in the maternal circulation that show characteristic methylation patterns. The development of fetal senses further illustrates how external stimulation may impact individual preferences. Here, we therefore not only discuss how maternal stress influences cognitive development and resilience, but also design possibilities of non-invasive interventions for both mothers and children summarized and evaluated in the light of their potential to improve the health of future generations.
On Trade Justice, Power and Institutions – Some Questions for Risse and Wollner
Authors: Suttle Oisin 
Published: September 2021

Abstract
While Risse and Wollner make an important contribution to theorising global justice and trade, I identify certain concerns with their approach and suggest an alternative that addresses these. First, I query their emphasis on subjection to the trade regime as a morally salient feature, suggesting their argument trades on an ambiguity, and fails to connect the trade regime, as a trigger, with their preferred account of trade-justice-as-non-exploitation. Second, I examine their treatment of the WTO, how they understand international organisations as inheritors of states’ obligations, and how far an organisation like the WTO can or should be self-consciously reoriented towards justice-as-non-exploitation. Third, I ask how their account is distinct from existing approaches, and whether it makes sense to apply the same conception of justice across diverse agents and institutions. I conclude by sketching an alternative approach, which makes the justification of states’ policies to outsiders the central problem of trade justice.
On the Road Again: King David as Involuntary Migrant
Authors: Strine C. A. 
Published: September 2021

Abstract
When David ben Jesse’s triumphant return from battle in 1 Sam 18 causes King Saul to despise him, the wheels are set in motion to make David an asylum seeker, refugee, and return migrant. It is burdened with those traumatic experiences that he is announced king in 2 Sam 2. What follows is a narrative of familial conflict and fracture, involuntary migration for David again (2 Sam 15), and a final return (2 Sam 20). From this point, David lives a sedentary life. Although this is an atypical summary of the narrative in 1 Sam 18–2 Kings 2, it foregrounds the important role involuntary migration plays in its plot. This article will explore that story, looking especially at how David’s attitude toward mobility as king is implicitly rejected by the narrative.
Preserving History for the Persistent Legacy of Our School: A Youth-Led Participatory Heritage Project
Authors: Allen-Handy Ayana , Meloche Alysha , Brown Jahyonna , Frazier Ayanna , Escalante Karena , Walker Marie , Burns Isaiah , Edwards-Chapman Nehemiah , Ervin Qudia , Thomas Anna , Thomas Melissa , Wortham Iminie , Bugg Destiny , Dia Janel 
Published: September 2021

AbstractThis in-process project report describes a critical youth-led participatory heritage project that seeks to document, preserve, and make digitally accessible oral histories, archives, and artifacts of an urban, predominantly African American high school with a rich history and legacy. As a long-standing community institution, the narratives emerging from this high school are intricately connected with the larger story of the city of Philadelphia. This article uses an equity-based lens to demonstrate how youth-led participatory heritage can contribute to youth empowerment, critical consciousness development, and critical digital literacies. Implications for schools and communities experiencing gentrification, displacement, and community change are provided, including how participatory heritage with youth can utilize collaborative, asset-based efforts to foster change that allows youth and communities to have agency over their individual and collective stories, community history and legacy, and their futures.
Photonic contact thermometry using silicon ring resonators and tuneable laser-based spectroscopy
Authors: Eisermann René , Krenek Stephan , Winzer Georg , Rudtsch Steffen 
Published: September 2021

Abstract
Photonic sensors offer the possibility of purely optical measurement in contact thermometry. In this work, silicon-based ring resonators were used for this purpose. These can be manufactured with a high degree of reproducibility and uniformity due to the established semiconductor manufacturing process. For the precise characterisation of these photonic sensors, a measurement setup was developed which allows laser-based spectroscopy around 1550 nm and stable temperature control from 5 °C to 95 °C. This was characterised in detail and the resulting uncertainty influences of both the measuring set-up and the data processing were quantified. The determined temperature stability at 20 °C is better than 0.51 mK for the typical acquisition time of 10 s for a 100 nm spectrum. For a measurement of >24 h at 30 °C a standard deviation of 2.6 mK could be achieved. A hydrogen cyanide reference gas cell was used for traceable in-situ correction of the wavelength. The determined correction function has a typical uncertainty of 0.6 pm. The resonance peaks of the ring resonators showed a high optical quality of 157 000 in the average with a filter depth of up to 20 dB in the wavelength range from 1525 nm to 1565 nm. When comparing different methods for the determination of the central wavelength of the resonance peaks, an uncertainty of 0.3 pm could be identified. A temperature-dependent shift of the resonance peaks of approx. 72 pm/K was determined. This temperature sensitivity leads together with the analysed uncertainty contributions to a repeatability of better than 10 mK in the analysed temperature range from 10 °C to 90 °C.
Evaluation of carnitine levels in dried blood spot samples in children with autism spectrum disorder
Authors: Aslan Ozgur , Kardaş Burcu , Özbek Mehmet Nuri , Ercan Bahadır 
Published: September 2021

Abstract

Objectives
Autism Spectrum Disorder is a neurodevelopmental disease with an average diagnosis age of over 3 years. Carnitine levels in ASD are important because they show potential mitochondrial dysfunction and abnormal fatty acid metabolism. In this study, in ASD children carnitine levels in dried blood spot samples were evaluated and compared with the control group.

Methods
Twentythree children diagnosed with ASD in Research and Training Hospital (19 boys, 4 girls) and age and gender matched 24 children without ASD were enrolled in this study. 17 carnitines in dried blood samples were measured with LC-MS/MS.

Results
C0, C2, C4-OH, C5, C5-OH, C6, C16, C18 carnitines were lower (p value 0.037, 0.010, 0.005, 0.032, 0.005, 0.003, 0.043, 0.003, respectively) and C18:1 carnitine was higher (p<0.025) in ASD group compared with control group.

Conclusions
Comprehensive carnitine levels for ASD are important to establish a treatment protocol for the treatment of ASD behavior and severity. C18:1 carnitine, detected for the first time in the cases with ASD, is important for its high levels and for being a glycine transporter two inhibitor. In ASD cases, the molecular analysis might be suggested for enzymes involved in carnitine metabolism and for glycine transporter 2.
Acute Effects of Foam Rolling on Blood Flow Measured by Ultrasonography in Soccer Players
Authors: Alonso-Calvete Alejandra , Padrón-Cabo Alexis , Lorenzo-Martínez Miguel , Rey Ezequiel 
Published: September 2021

Abstract
Alonso-Calvete, A, Padrón-Cabo, A, Lorenzo-Martínez, M, and Rey, E. Acute Effects of Foam Rolling on Blood Flow Measured by Ultrasonography in Soccer Players. J Strength Cond Res 35(11): 3256–3259, 2021—In recent years, foam rolling (FR) has become a popular device for recovery to increase range of motion and decrease pain after sport practice and competition. However, there is little evidence about the underlying physiological effects of FR, specifically in blood flow parameters. Thus, the aim of this study was to analyze acute effects of FR on blood flow parameters (maximal velocity and maximal volume) measured by Doppler ultrasonography in soccer players. Twelve soccer players were assessed in 3 different situations: pre-FR intervention, immediately after FR intervention, and 30 minutes after FR intervention. The femoral artery was measured in the dominant leg with subjects in horizontal lying position. Before the intervention, subjects completed one familiarization session with FR. The FR intervention consisted of 2 sets, each with 45 seconds of FR and 15 seconds of rest between sets with a high-density foam roller in quadriceps, hamstrings, and iliotibial band. Results showed a significant increase in both maximal velocity (p < 0.001; effect size [ES] = 0.81) and maximal volume (p = 0.001; ES = 1.73) after intervention in comparison with pretest, but after 30 minutes, there were no significant differences. Therefore, this increase of the blood flow could promote important advantages for postexercise recovery, suggesting an acute effect that may contribute to the understanding of local physiological mechanism of FR.