bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Type 2 Diabetes on Women’s Health and Well-being During Their Reproductive Years: A Mixed-methods Systematic Review
Authors: Celik Aycan , Forde Rita , Racaru Simona , Forbes Angus , Sturt Jackie 
Published: January 2021

Background:The incidence of type 2 diabetes (T2DM) among younger women now accounts for 40% of females with T2DM. Women of reproductive age with T2DM have additional health considerations and their needs may differ from older populations.Objectives:To identify the health issues encountered by women aged 16-45 years living with T2DM; to determine the modifiable risk factors associated with living with diabetes; to specify ideas for interventions to meet age and genderspecific diabetes-related healthcare needs.Methods:A systematic search was performed in the following databases; MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, and Maternity and Infant Care. Databases were searched without time and study design limits. The Mixed Methods Appraisal Tool was used to assess the methodological quality of included studies. Data were narratively synthesised due to the mixed methods evidence included.Results:A total of 32 papers were included in the review from which six domains were identified from the synthesis: (1) diabetes related modifiable risk factors: blood glucose, cardiovascular risk, neuropathy/nephropathy/retinopathy, diabetes self-management barriers (2) reproductive health: diabetes care before pregnancy, pre-pregnancy care barriers and expectations of women, contraceptive use (3) psychosocial wellbeing: depression symptoms and diabetes distress, perception of T2DM, emotional concerns about pregnancy (4) sexual function; (5) menopause; (6) sociocultural factors: social support, cultural norms.Conclusion:This review highlighted specific health issues affecting women of reproductive age with T2DM and which represent an important focus for health services research and health care delivery. Future research needs to address identified health domains to improve women’s health and well-being living with T2DM. Prospero Registration number: CRD42019146535.
Simultaneous Detection of Phillyrin and its Three Metabolites in Rat Bile, Excrement and Urine via HPLC-ESI-MS/MS Quantitative Method
Authors: Zhang Lantong , Liu Xizhe , Li Feigao 
Published: January 2021

Introduction:
Phillyrin, the main pharmacological component of Forsythia suspensa,
exhibits a wide variability of therapeutic activities, such as anti-oxidative stress, free radicalclearing,
antibacterial activity, hepatic protection, restoration of endothelial glycocalyx damage,
prevention of bone loss, attenuation of inflammatory responses, and so on. Previous research has
found that phillyrin is not easily absorbed by the body and is rarely excreted into bile, excrement
and urine, suggesting that phillyrin circulates primarily in the form of metabolites.

Materials and Methods:
In the present study, HPLC-ESI-MS/MS method was used for the simultaneous
detection of phillyrin and its three metabolites in rat bile, excrement and urine samples.
Liquid-liquid extraction with ethyl acetate was carried out for the pretreatment of bile and urine
samples, while excrement samples were subjected to ultrasonic pretreatment with acetone. Chromatographic
separation was performed on a C18 column with gradient elution. A tandem mass
system coupled with a TurboIonSpray interface operating in simultaneous positive and negative
ion multiple reaction monitoring modes was employed for the simultaneous detection of
the analytes.

Results:
The proposed method demonstrated excellent accuracy and repeatability.

Conclusion:
This method was successfully applied for the pharmacokinetic evaluation of phillyrin
and its three metabolites simultaneously.
Spectrophotometric Determination of Vitamin B1 in Dosage forms Using Drugs Compounds as Reagents by Normal and Reverse Flow Injection Methods
Authors: Amir Rana , Hadi Hind 
Published: January 2021

Background:
Thiamine hydrochloride (THY), also known as vitamin B1, is a water
soluble vitamin usually found in food, and considered as a dietary supplement and treatment in
case of vitamin deficiency for example in malabsorption and chronic diarrhea.

Objective:
Rapid, green, and sensitive methods for the assay of vitamin B1 (thiamine hydrochloride,
THY) in pharmaceutical forms, using normal and reverse flow injection manifolds and sulfonamide
drugs as green and safe reagents were reported. Sulfamethoxazole and sulfadimidine
drugs were used rather than toxic and expensive reagents.

Methods:
nFIA and rFIA manifolds were used for automated the reaction of THY with diazotized
sulfamethoxazole (DSMZ) and diazotized sulfadimidine (DSDM) in an alkaline medium, respectively.
The absorbance of the resultant red-orange azo dyes was monitored spectrophotometrically
at λmax494 and 496nm for both methods, respectively.

Results:
The linearity of the suggested methods was in the ranges 2–80 µg/mL (LOD 0.69
µg/mL, % RSD 0.32, n=6) for nFIA method and 0.5-70 µg/mL (LOD 0.29 µg/mL, %RSD 0.85,
n=6) for rFIA. Sampling frequency was 84 and 51 injections per hour for nFIA and rFIA
methods respectively. Chemical and physical variables for both methods were studied carefully.

Conclusion:
Both flow injection modes were effectively applied in assay of THY in its
pharmaceutical forms. The results were compared with those of standard pharmacopeia method
and the statistical analysis indicated insignificant differences in accuracy and precision between
the methods.
The Uses of Dimedone for the Synthesis of Thiophene, Thiazole and Annulated Derivatives with Antitumor, Pim-1 Kinase Inhibitions, PAINS Evaluations and Molecular Docking
Authors: Wardakhan Wagnat W. , Elmetwally Amira M. , Mohamed Abeer A. , Mohareb Rafat M. 
Published: January 2021

Background:
Dimedone is considered as one of the most important classes of compounds belonging
to cyclohexan-1,3-dione. Such groups of compounds were considered as precursors for many pharmaceutically
active heterocyclic compounds.

Objective:
The target molecules in this work were synthesized from arylhydrazones of dimedone with different
substituents enhancing the study of their structure-activity relationship.

Methods:
Arylhydrazones of dimedones were subjected to a series of heterocyclization reactions affording annulated
compounds. The anti-proliferative activities of the synthesized molecules were evaluated against six
cancer cell lines. In addition, inhibitions toward tyrosine kinases, Pim-1 kinases and PAINS of the most active
compounds were also studied. c-Met enzymatic inhibitions and molecular docking studies were carried out for
three compounds.

Results:
Anti-cancer evaluations together with tyrosine and Pim-1 kinases of most of the synthesized compounds
were carried out through this work. The study revealed that changing of substituents had a strong impact
on the activity of the molecule.

Conclusion:
Many of the synthesized compounds exhibited high inhibitions towards the six cancer cell lines.
This will encourage further work through the synthesis of target molecules with the same ring systems. The
three compounds 7b, 8c and 12b that revealed excellent inhibitions were tested against c-Met kinase and their
molecular modelling was expressed.
ATP-sensitive Potassium Channel Subunits in Neuroinflammation: Novel
Drug Targets in Neurodegenerative Disorders
Authors: Maqoud Fatima , Scala Rosa , Hoxha Malvina , Zappacosta Bruno , Tricarico Domenico 
Published: January 2021

:
Arachidonic acids and its metabolites modulate plenty of ligand-gated, voltage-dependent
ion channels, and metabolically regulated potassium channels including ATP-sensitive potassium
channels (KATP). KATP channels are hetero-multimeric complexes of sulfonylureas receptors
(SUR1, SUR2A or SUR2B) and the pore-forming subunits (Kir6.1 and Kir6.2) likewise expressed
in the pre-post synapsis of neurons and inflammatory cells, thereby affecting their proliferation and
activity. KATP channels are involved in amyloid-β (Aβ)-induced pathology, therefore emerging as
therapeutic targets against Alzheimer’s and related diseases. The modulation of these channels can
represent an innovative strategy for the treatment of neurodegenerative disorders; nevertheless, the
currently available drugs are not selective for brain KATP channels and show contrasting effects.
This phenomenon can be a consequence of the multiple physiological roles of the different varieties
of KATP channels. Openings of cardiac and muscular KATP channel subunits, are protective
against caspase-dependent atrophy in these tissues and some neurodegenerative disorders, whereas
in some neuroinflammatory diseases, benefits can be obtained through the inhibition of neuronal
KATP channel subunits. For example, glibenclamide exerts an anti-inflammatory effect in respiratory,
digestive, urological, and central nervous system (CNS) diseases, as well as in ischemia-reperfusion
injury associated with abnormal SUR1-Trpm4/TNF-α or SUR1-Trpm4/ Nos2/ROS signaling.
Despite this strategy being promising, glibenclamide may have limited clinical efficacy due to
its unselective blocking action of SUR2A/B subunits also expressed in cardiovascular apparatus
with pro-arrhythmic effects and SUR1 expressed in pancreatic beta cells with hypoglycemic risk.
Alternatively, neuronal selective dual modulators showing agonist/antagonist actions on KATP
channels can be an option.
An Investigation of Multilingual TDNN-BLSTM Acoustic Modeling for
Hindi Speech Recognition
Authors: Kumar Ankit , Aggarwal Rajesh Kumar 
Published: January 2021

Background:
In India, thousands of languages or dialects are in use. Most Indian dialects are low asset dialects.
A well-performing Automatic Speech Recognition (ASR) system for Indian languages is unavailable due to a lack of
resources. Hindi is one of them as large vocabulary Hindi speech datasets are not freely available. We have only a few hours
of transcribed Hindi speech dataset. There is a lot of time and money involved in creating a well-transcribed speech dataset.
Thus, developing a real-time ASR system with a few hours of the training dataset is the most challenging task. The different
techniques like data augmentation, semi-supervised training, multilingual architecture, and transfer learning, have been
reported in the past to tackle the fewer speech data issues. In this paper, we examine the effect of multilingual acoustic
modeling in ASR systems for the Hindi language.

Objective:
This article’s objective is to develop a high accuracy Hindi ASR system with a reasonable computational load
and high accuracy using a few hours of training data.

Method:
To achieve this goal we used Multilingual training with Time Delay Neural Network- Bidirectional Long Short
Term Memory (TDNN-BLSTM) acoustic modeling. Multilingual acoustic modeling has significantly improved the ASR
system's performance for low and limited resource languages. The common practice is to train the acoustic model by
merging data from similar languages. In this work, we use three Indian languages, namely Hindi, Marathi, and Bengali.
Hindi with 2.5 hours of training data and Marathi with 5.5 hours of training data and Bengali with 28.5 hours of transcribed
data, was used in this work to train the proposed model.

Results:
The Kaldi toolkit was used to perform all the experiments. The paper is investigated over three main points. First,
we present the monolingual ASR system using various Neural Network (NN) based acoustic models. Second, we show that
Recurrent Neural Network (RNN) language modeling helps to improve the ASR performance further. Finally, we show that
a multilingual ASR system significantly reduces the Word Error Rate (WER) (absolute 2% WER reduction for Hindi and
3% for the Marathi language). In all the three languages, the proposed TDNN-BLSTM-A multilingual acoustic models help
to get the lowest WER.

Conclusion:
The multilingual hybrid TDNN-BLSTM-A architecture shows a 13.67% relative improvement over the
monolingual Hindi ASR system. The best WER of 8.65% was recorded for Hindi ASR. For Marathi and Bengali, the
proposed TDNN-BLSTM-A acoustic model reports the best WER of 30.40% and 10.85%.
History and Global Status of the New Coronavirus Covid-2019 and Aspects of Previous Infections of SARS-CoV and MERS-CoV: A Systematic Review
Authors: da Costa Amanda Pinato Alves , da Rocha Vinicius Lisboa , Ramos Rogério Rodrigo , Neto José Martins Pinto , da Silva Wagner Rafael , Pereira Luis Lenin Vicente , Ramos Kelys , Marques Tais Cristina Nascimento , Filho Idiberto José Zotarelli , Lozano André Wilian 
Published: January 2021

Introduction:
Coronaviruses (CoV) is a diverse group of viruses that has been described
in the literature since 1960, SARS, MERS, and the most recent SARS-CoV-2. This new virus is
causing a worldwide pandemic outbreak in the first half of 2020, thousands of deaths, and a significant
economic crisis.

Objective:
Due to this new context, the present study aimed to conduct a systematic study review
of the new Coronavirus's global status (COVID-2019) and its aspects compared to the previous
SARS-CoV infections MERS-CoV.

Methods:
The study was conducted from January to September 2020, 89 clinical cases were submitted
to further analysis, and 77 studies were selected for systematic review under the PRISMA
guidelines.

Major findings and Conclusion:
In some countries, the SARS-CoV-2 pandemic appears to be out of control. In case of
suspicion, tests are essential to identify the early stages of infection. If necessary, patients need to
go into quarantine, and other public health measures should be taken following the World Health
Organization guidelines. Advanced support is needed to identify and isolate infected patients, especially
vaccines and medicines that help control the virus and the epidemiological situation in each
country. These measures are expected to reduce the rate of new cases of SARS-CoV-2.
Evaluation of an Intergenerational and Technological Intervention for Loneliness: Protocol for a Feasibility Randomized Controlled Trial
Authors: Hoang Peter , Whaley Colin , Thompson Karen , Ho Venus , Rehman Uzma , Boluk Karla , Grindrod Kelly A 
Published: January 2021

Background
Social integration and mental health are vital aspects of healthy aging. However, close to half of Canadians older than 80 years report feeling socially isolated. Research has shown that social isolation leads to increased mortality and morbidity, and various interventions have been studied to alleviate loneliness among older adults. This proposal presents an evaluation of an intervention that provides one-on-one coaching, is intergenerational, provides both educational and socialization experiences, and increases technology literacy of older adults to overcome loneliness.

Objective
This paper describes the protocol of a randomized, mixed-methods study that will take place in Ontario, Canada. The purpose of this study is to evaluate if an intergenerational technology literacy program can reduce social isolation and depression in older adults via quantitative and qualitative outcome measures.

Methods
This study is a randomized, mixed-methods, feasibility trial with 2 conditions. Older adults in the intervention condition will receive 1 hour of weekly technological assistance to send an email to a family member, for 8 weeks, with the assistance of a volunteer. Participants in the control condition will not receive any intervention. The primary outcomes are loneliness, measured using the University of California, Los Angeles Loneliness Scale, and depression, measured using the Center for Epidemiologic Studies Depression scale, both of which are measured weekly. Secondary outcomes are quality of life, as assessed using the Older People’s Quality of Life-Brief version, and technological literacy, evaluated using the Computer Proficiency Questionnaire-12, both of which will be administered before and after the intervention. Semistructured interviews will be completed before and after the intervention to assess participants’ social connectedness, familiarity with technology, and their experience with the intervention. The study will be completed in a long-term care facility in Southwestern Ontario, Canada. Significance was set at P<.05.

Results
This study was funded in April 2019 and ethical approval was obtained in August 2019. Recruitment for the study started in November 2019. The intervention began in February 2020 but was halted due to the COVID-19 pandemic. The trial will be restarted when safe. As of March 2020, 8 participants were recruited.

Conclusions
Information and communication technology interventions have shown varying results in reducing loneliness and improving mental health among older adults. Few studies have examined the role of one-on-one coaching for older adults in addition to technology education in such interventions. Data from this study may have the potential to provide evidence for other groups to disseminate similar interventions in their respective communities.

International Registered Report Identifier (IRRID)
DERR1-10.2196/23767
Use of Telehealth in Substance Use Disorder Services During and After COVID-19: Online Survey Study
Authors: Molfenter Todd , Roget Nancy , Chaple Michael , Behlman Stephanie , Cody Olivia , Hartzler Bryan , Johnson Edward , Nichols Maureen , Stilen Patricia , Becker Sara 
Published: January 2021

Background
Social distancing guidelines for COVID-19 have caused a rapid transition to telephone and video technologies for delivering treatment for substance use disorders (SUDs).

Objective
This study examined the adoption of these technologies across the SUD service continuum, acceptance of these technologies among service providers, and intent of providers to use these technologies after the pandemic. Additional analysis using the validated technology acceptance model (TAM) was performed to test the potential applications of these technologies after the pandemic. The study objectives were as follows: (1) to assess the use of telehealth (telephone and video technologies) for different SUD services during COVID-19 in May-June 2020, (2) to assess the intended applications of telehealth for SUD services beyond COVID-19, (3) to evaluate the perceived ease of use and value of telehealth for delivering SUD services, and (4) to assess organizational readiness for the sustained use of telehealth services.

Methods
An online survey on the use of telephonic and video services was distributed between May and August 2020 to measure the current use of these services, perceived organizational readiness to use these services, and the intent to use these services after COVID-19. In total, 8 of 10 regional Addiction Technology Transfer Centers representing 43 states distributed the survey. Individual organizations were the unit of analysis.

Results
In total, 457 organizations responded to the survey. Overall, the technology was widely used; >70% (n>335) of organizations reported using telephone or video platforms for most services. The odds of the intent of organizations to use these technologies to deliver services post COVID-19 were significantly greater for all but two services (ie, telephonic residential counseling and buprenorphine therapy; mean odds ratio 3.79, range 1.87-6.98). Clinical users preferred video technologies to telephone technologies for virtually all services. Readiness to use telephone and video technologies was high across numerous factors, though telephonic services were considered more accessible. Consistent with the TAM, perceived usefulness and ease of use influenced the intent to use both telephone and video technologies.

Conclusions
The overall perceived ease of use and usefulness of telephonic and video services suggest promising post–COVID-19 applications of these services. Survey participants consistently preferred video services to telephonic services; however, the availability of telephonic services to those lacking easy access to video technology is an important characteristic of these services. Future studies should review the acceptance of telehealth services and their comparative impact on SUD care outcomes.
Understanding Health Empowerment From the Perspective of Information Processing: Questionnaire Study (Preprint)
Authors: Jiang Fei , Liu Yongmei , Hu Junhua , Chen Xiaohong 
Published: January 2021

BACKGROUND

Massive, easily accessible online health information empowers users to cope with health problems better. Most patients search for relevant online health information before seeing a doctor to alleviate information asymmetry. However, the mechanism of how online health information affects health empowerment is still unclear.

OBJECTIVE

To study how online health information processing affects health empowerment.

METHODS

We conducted a cross-sectional questionnaire study that included 343 samples from participants who had searched online health information before the consultation. Respondents' perceptions of online information cues, benefits, health literacy, and health empowerment were assessed.

RESULTS

Perceived argument quality and perceived source credibility have significant and positive effects on perceived information benefits, but only perceived argument quality has a significant effect on perceived decision-making benefits. Two types of perceived benefits, in turn, affect health empowerment. The effects of perceived argument quality on perceived informational benefits and perceived decision-making benefits on health empowerment are significantly stronger for the high health literacy group than the low health literacy group (t<sub>269</sub>=7.156, <i>P</i>&lt;.001; t<sub>269</sub>=23.240, <i>P</i>&lt;.001). While, the effects of perceived source credibility on perceived informational benefits and perceived informational benefits on health empowerment are significantly weaker for the high health literacy group than the low health literacy group (t<sub>269</sub>=–10.497, <i>P</i>&lt;.001; t<sub>269</sub>=–6.344, <i>P</i>&lt;.001). The effect of perceived argument quality on perceived informational benefits shows no significant difference between high and low health literacy groups.

CONCLUSIONS

In the context of online health information, perceived information benefits and perceived decision-making benefits are the antecedents of health empowerment, which in turn will be affected by perceived argument quality and perceived source credibility. Health literacy plays a moderating role in the relationship of some variables. To maximize health empowerment, online health information providers should strengthen information quality and provide differentiated information services based on users' health literacy.