bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do the grain size characteristics of a tephra deposit change over time?
Authors: Cutler Nick A. , Streeter R. T. , Dugmore A. J. , Sear E. R. 
Published: June 2021

AbstractVolcanologists frequently use grain size distributions (GSDs) in tephra layers to infer eruption parameters. However, for long-past eruptions, the accuracy of the reconstruction depends upon the correspondence between the initial tephra deposit and preserved tephra layer on which inferences are based. We ask: how closely does the GSD of a decades-old tephra layer resemble the deposit from which it originated? We addressed this question with a study of the tephra layer produced by the eruption of Mount St Helens, USA, in May 1980. We compared grain size distributions from the fresh, undisturbed tephra with grain size measurements from the surviving tephra layer. We found that the overall grain size characteristics of the tephra layer were similar to the original deposit, and that distinctive features identified by earlier authors had been preserved. However, detailed analysis of our samples showed qualitative differences, specifically a loss of fine material (which we attributed to ‘winnowing’). Understanding how tephra deposits are transformed over time is critical to efforts to reconstruct past eruptions, but inherently difficult to study. We propose long-term, tephra application experiments as a potential way forward.
Endurance-oriented training program with children and adolescents on maintenance hemodialysis to enhance dialysis efficacy—DiaSport
Authors: Feldkötter Markus , Thys Sarah , Adams Anne , Becker Ingrid , Büscher Rainer , Pohl Martin , Schild Raphael , Pape Lars , Schmitt Claus Peter , Taylan Christina , Wygoda Simone , Klaus Günter , Fehrenbach Henry , Montoya Carmen , Konrad Martin , Billing Heiko , Schaar Bettina , Hoppe Bernd 
Published: June 2021

Abstract
Objective
Pediatric patients spend significant time on maintenance hemodialysis (HD) and traveling. They are often not capable of participating in sports activities. To assess the effects of exercise training during HD on dialysis efficacy in children and adolescents, we set up a multi-center randomized controlled trial (RCT).

Methods
Patients on HD, age 6 to 18 years, were randomized either to 3× weekly bicycle ergometer training or to no training during HD for 12 weeks. Change in single-pool Kt/V (spKt/V) was the primary outcome parameter.

Results
We randomized 54 patients of whom 45 qualified (23 in the intervention and 22 in the waiting control group, 14.5 ± 3.01 years, 32 male and 13 female) for the intention-to-treat (ITT) population. Only 26 patients finished study per-protocol (PP). Training was performed for an average of 11.96 weeks (0.14–13.14) at 2.08 ± 0.76 times per week and for a weekly mean of 55.52 ± 27.26 min. Single-pool Kt/V was similar in the intervention compared to the control group (1.70 [0.33] vs. 1.79 [0.55]) at V0 and (1.70 [0.36] vs. 1.71 [0.51]) at V1; secondary endpoints also showed no difference in both ITT and PP analysis. No significant adverse events were reported. No bleeding or needle dislocation occurred in 1670 training sessions.

Conclusions
Intradialytic bicycle training is safe, but does not improve dialysis efficacy and physical fitness. However, the study can be considered underpowered, particularly because of high dropout rates. Future studies need better strategies to increase motivation and compliance and other more effective/intensive exercise measures should be evaluated.

Trial registration
The trial was registered in ClinicalTrials.Gov (Clinicaltrials.gov identifier: NCT01561118) on March 22, 2012.
CuAg and AuAg bimetallic nanoparticles for catalytic and heat transfer applications
Authors: Dsouza Anusha , Shilpa M. P. , Gurumurthy S. C. , Nagaraja B. S. , Mundinamani Shridhar , Ramam Koduri , Gedda Murali , Murari M. S. 
Published: June 2021

AbstractBimetallic nanoparticles (BNPs) have drawn significant attention due to their numerous applications. They demonstrate enhanced optical, electrical, thermal, and catalytic properties due to the synergistic effects of monometals present in them. In this work, CuAg and AuAg BNPs have been synthesized using a facile and economical chemical reduction method. Optical characterization was carried out using UV–visible spectroscopy, and effect of pH on optical absorbance was studied. For CuAg and AuAg BNPs, optimum pH was observed to be at 9.4 and 6.39, respectively. Morphological investigation confirms the average diameters of CuAg and AuAg BNPs were to be 65 nm and 30 nm, respectively. Photocatalytic property illustrates the reduction of 4-nitrophenol to 4-aminophenol with a 92% conversion percentage in the presence of CuAg BNPs in 4 min, and rate constant for the reaction was measured to be 8.98 × 10–3 s−1. But for the AuAg BNPs, the conversion percentage was 97% in 8 min and rate constant was found to be 7.95 × 10–3 s−1. Thermal conductivity and viscosity measurements of the nanofluids obtained with CuAg and AuAg BNPs have ascertained them to be efficient candidates for the heat transfer and catalytic applications.
Graphic abstract
External validation of the Briganti 2019 nomogram to identify candidates for extended pelvic lymph node dissection among patients with high-risk clinically localized prostate cancer
Authors: Fukagawa Eri , Yamamoto Shinya , Ohde Sachiko , Yoshitomi Kasumi Kaneko , Hamada Kosuke , Yoneoka Yusuke , Fujiwara Motohiro , Fujiwara Ryo , Oguchi Tomohiko , Komai Yoshinobu , Numao Noboru , Yuasa Takeshi , Fukui Iwao , Yonese Junji 
Published: June 2021

Abstract
Background
We aimed to establish an external validation of the Briganti 2019 nomogram in a Japanese cohort to preoperatively evaluate the probability of lymph node invasion in patients with high-risk, clinically localized prostate cancer.

Methods
The cohort consisted of 278 patients with prostate cancer diagnosed using magnetic resonance imaging-targeted biopsy who underwent radical prostatectomy and extended pelvic lymph node dissection from 2012 to 2020. Patients were rated using the Briganti 2019 nomogram, which evaluates the probability of lymph node invasion. We used the area under curve of the receiver operating characteristic analysis to quantify the accuracy of the nomogram.

Results
Nineteen (6.8%) patients had lymph node invasion. The median number of lymph nodes removed was 18. The area under the curve for the Briganti 2019 was 0.71. When the cutoff was set at 7%, 84 (30.2%) patients with extended pelvic lymph node dissection could be omitted, and only 1 (1.2%) patient with lymph node invasion would be missed. Sensitivity, specificity, and negative predictive values at the 7% cutoff were 94.7, 32.0, and 98.8%, respectively.

Conclusion
This external validation showed that the Briganti 2019 nomogram was accurate, although there may still be scope for individual adjustments.
Local excision and treatment of early node-negative anal squamous cell carcinomas in a highly HIV prevalent population
Authors: Brogden D. R. L. , Kontovounisios C. , Chong I. , Tait D. , Warren O. J. , Bower M. , Tekkis P. , Mills S. C. 
Published: June 2021

Abstract
Background
Anal squamous cell carcinoma (ASCC) is an uncommon cancer associated with human immunodeficiency virus (HIV) infection. There has been increasing interest in providing organ-sparing treatment in small node-negative ASCC’s, however, there is a paucity of evidence about the use of local excision alone in people living with HIV (PLWH). The aim of this study was to evaluate the efficacy of local excision alone in this patient population.

Methods
We present a case series of stage 1 and stage 2 ASCC in PLWH and HIV negative patients. Data were extracted from a 20-year retrospective cohort study analysing the treatment and outcomes of patients with primary ASCC in a cohort with a high prevalence of HIV.

Results
Ninety-four patients were included in the analysis. Fifty-seven (61%) were PLWH. Thirty-five (37%) patients received local excision alone as treatment for ASCC, they were more likely to be younger (p = 0.037, ANOVA) and have either foci of malignancy or well-differentiated tumours on histology (p = 0.002, Fisher’s exact test).
There was no statistically significant difference in 5-year disease-free survival and recurrence between treatment groups, however, patients who had local excision alone and PLWH were both more likely to recur later compared to patients who received other treatments for ASCC. (72.3 months vs 27.3 months, p = 0.06, ANOVA, and 72.3 months vs 31.8 months, p = 0.035, ANOVA, respectively).

Conclusions
We recommend that local excision be considered the sole treatment for stage 1 node-negative tumours that have clear margins and advantageous histology regardless of HIV status. However, PLWH who have local excision alone must have access to an expert long-term surveillance programme after treatment to identify late recurrences.
Human papillomavirus in Italy: retrospective cohort analysis and preliminary vaccination effect from real-world data
Authors: Marcellusi A. , Mennini F. S. , Sciattella P. , Favato G. 
Published: June 2021

Abstract
Introduction
The objective of this study was to estimate the lifetime risk of hospitalization associated with all major human papillomavirus (HPV)-related diseases in Italy. Moreover, a preliminary vaccination effect was also performed.

Methods
A retrospective, nonrandomized, observational study was developed based on patients hospitalized between 2006 and 2018 in Italy. All hospitalizations were identified through administrative archives, according to the International Classification of Diseases (ICD-9 CM). Information related to the hospital discharges of all accredited public and private hospitals, both for ordinary and day care regimes, was taken into account. We included hospitalizations related to resident patients presenting one of the ICD-9-CM codes as primary or secondary diagnosis: genital warts (GW); ‘cervical intraepithelial neoplasia (CIN)’ (067.32–067.33); ‘condyloma acuminatum’ (078.11); ‘anal cancers’ (AC) (154.2–154.8); oropharyngeal cancers (OC): ‘oropharyngeal cancer’(146.0–146.9) and ‘head, face and neck cancers’ (171.0); genital cancers (GC): ‘penis cancer’ (187.1–187.9) and ‘cervical cancer’ (180.0–180.9). Data were stratified by birth year and divided into two groups: (a) cohort born before 1996 (not vaccinable) and (b) cohort born after 1997 (vaccinable—first cohort that could be vaccinated at the beginning of immunization schedule in girls since 2008 in Italy). Disease-specific hospitalization risks for both groups were estimated by sex, year and age.

Results
Epidemiological data demonstrate that the peak hospitalization risk occurred at 24–26 years of age for GW (both male and female); 33–41 and 47–54 years for AC males and females, respectively; 53–59 and 52–58 years for OC males and females, respectively; and 54–60 and 39–46 years for GC males and females, respectively. Focusing on GW and GC, vaccinable females demonstrate a significant reduction in hospitalization risks (− 54% on average) compared to nonvaccinable females until 21 years of age (maximum follow-up available for girls born after 1997). Comparing the same birth cohort of males, no differences in hospitalization risk were found.

Conclusions
These results support the importance of primary prevention strategies in Italy and suggest that increased VCRs and time of observation (genital cancers for which vaccination is highly effective, have a latency of some decades) will provide useful information for decision-makers.
Coverage with evidence development schemes for medical devices in Europe: characteristics and challenges
Authors: Federici Carlo , Reckers-Droog Vivian , Ciani Oriana , Dams Florian , Grigore Bogdan , Kaló Zoltán , Kovács Sándor , Shatrov Kosta , Brouwer Werner , Drummond Michael 
Published: June 2021

Abstract
Objectives
Medical devices are potentially good candidates for coverage with evidence development (CED) schemes, as clinical data at market entry are often sparse and (cost-)effectiveness depends on real-world use. The objective of this research was to explore the diffusion of CED schemes for devices in Europe, and the factors that favour or hamper their utilization.

Methods
We conducted structured interviews with 25 decision-makers from 22 European countries to explore the characteristics of existing CED programmes for devices, and how decision makers perceived 13 pre-identified challenges associated with initiating and operating CED schemes for devices. We also collected data on individual schemes that were either initiated or still ongoing in the last 5 years.

Results
We identified seven countries with CED programmes for devices and 78 ongoing schemes. The characteristics of CED programmes varied across countries, including eligibility criteria, roles and responsibilities of stakeholders, funding arrangements, and type of decisions being contemplated at the outset of each scheme. We observed a high variability in how decision makers perceived CED-related challenges possibly reflecting country-specific arrangements and different experiences with CED. One general finding across all countries was that relatively little attention was paid to the evaluation of schemes, both during and at their completion.

Conclusions
CED programmes for devices with different characteristics exist in Europe. Decision-makers’ perceptions differ on the challenges associated with these schemes. More exchange of knowledge and experience will help decision makers anticipate the likely challenges in CED schemes for devices, and to learn from good practices existing elsewhere.
A comparative study on a complex URM building: part II—issues on modelling and seismic analysis through continuum and discrete-macroelement models
Authors: Castellazzi G. , Pantò B. , Occhipinti G. , Talledo D. A. , Berto L. , Camata G. 
Published: June 2021

AbstractThe paper presents the comparison of the results obtained on a masonry building by nonlinear static analysis using different software operating in the field of continuum and discrete-macroelement modeling. The structure is inspired by an actual building, the "P. Capuzi" school in Visso (Macerata, Italy), seriously damaged following the seismic events that affected Central Italy from August 2016 to January 2017. The activity described is part of a wider research program carried out by various units involved in the ReLUIS 2017/2108—Masonry Structures project and having as its object the analysis of benchmark structures for the evaluation of the reliability of software packages. The comparison of analysis was carried out in relation to: global parameters (concerning the dynamic properties, capacity curves and, equivalent bilinear curves), synthetic parameters of structural safety (such as, for example, the maximum acceleration compatible with the life safety limit state) and the response in terms of simulated damage. The results allow for some insights on the use of continuum and discrete-macroelement modeling, with respect to the dispersion of the results and on the potential repercussions in the professional field. This response was also analyzed considering different approaches for the application of loads.
The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ
Authors: Al-Kawaz Abdulbaqi , Miligy Islam M. , Toss Michael S. , Mohammed Omar J. , Green Andrew R. , Madhusudan Srinivasan , Rakha Emad A. 
Published: June 2021

AbstractBackgroundImpaired DNA repair mechanism is one of the cancer hallmarks. Flap Endonuclease 1 (FEN1) is essential for genomic integrity. FEN1 has key roles during base excision repair (BER) and replication. We hypothesised a role for FEN1 in breast cancer pathogenesis. This study aims to assess the role of FEN1 in breast ductal carcinoma in situ (DCIS).MethodsExpression of FEN1 protein was evaluated in a large (n = 1015) well-characterised cohort of DCIS, comprising pure (n = 776) and mixed (DCIS coexists with invasive breast cancer (IBC);n = 239) using immunohistochemistry (IHC).ResultsFEN1 high expression in DCIS was associated with aggressive and high-risk features including higher nuclear grade, larger tumour size, comedo type necrosis, hormonal receptors negativity, higher proliferation index and triple-negative phenotype. DCIS coexisting with invasive BC showed higher FEN1 nuclear expression compared to normal breast tissue and pure DCIS but revealed significantly lower expression when compared to the invasive component. However, FEN1 protein expression in DCIS was not an independent predictor of local recurrence-free interval.ConclusionHigh FEN1 expression is linked to features of aggressive tumour behaviour and may play a role in the direct progression of DCIS to invasive disease. Further studies are warranted to evaluate its mechanistic roles in DCIS progression and prognosis.
Predicting pathological axillary lymph node status with ultrasound following neoadjuvant therapy for breast cancer
Authors: Skarping Ida , Förnvik Daniel , Zackrisson Sophia , Borgquist Signe , Rydén Lisa 
Published: June 2021

Abstract
Purpose
High-performing imaging and predictive markers are warranted to minimize surgical overtreatment of the axilla in breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Here we have investigated whether axillary ultrasound (AUS) could identify axillary lymph node (ALN) metastasis (ALNM) pre-NACT and post-NACT for BC. The association of tumor, AUS features and mammographic density (MD) with axillary-pathological complete response (axillary-pCR) post-NACT was also assessed.

Methods
The NeoDense-study cohort (N = 202, NACT during 2014–2019), constituted a pre-NACT cohort, whereas patients whom had a cytology verified ALNM pre-NACT and an axillary dissection performed (N = 114) defined a post-NACT cohort. AUS characteristics were prospectively collected pre- and post-NACT. The diagnostic accuracy of AUS was evaluated and stratified by histological subtype and body mass index (BMI). Predictors of axillary-pCR were analyzed, including MD, using simple and multivariable logistic regression models.

Results
AUS demonstrated superior performance for prediction of ALNM pre-NACT in comparison to post-NACT, as reflected by the positive predictive value (PPV) 0.94 (95% CI 0.89–0.97) and PPV 0.76 (95% CI 0.62–0.87), respectively. We found no difference in AUS performance according to neither BMI nor histological subtype. Independent predictors of axillary-pCR were: premenopausal status, ER-negativity, HER2-overexpression, and high MD.

Conclusion
Baseline AUS could, to a large extent, identify ALNM; however, post-NACT, AUS was insufficient to determine remaining ALNM. Thus, our results support the surgical staging of the axilla post-NACT. Baseline tumor biomarkers and patient characteristics were predictive of axillary-pCR. Larger, multicenter studies are needed to evaluate the performance of AUS post-NACT.
The orbital evolution of resonant chains of exoplanets incorporating circularisation produced by tidal interaction with the central star with application to the HD 158259 and EPIC 245950175 systems
Authors: Papaloizou J. C. B. 
Published: June 2021

AbstractWe study orbital evolution of multi-planet systems that form a resonant chain, with nearest neighbours close to first order commensurabilities, incorporating orbital circularisation produced by tidal interaction with the central star. We develop a semi-analytic model applicable when the relative proximities to commensurability, though small, are large compared to $$\epsilon ^{2/3},$$

ϵ

2
/
3

,

with $$\epsilon $$
ϵ
being a measure of the characteristic planet to central star mass ratio. This enables determination of forced eccentricities as well as which resonant angles enter libration. When there are no active linked three body Laplace resonances, the rate of evolution of the semi-major axes may also be determined. We perform numerical simulations of the HD 158259 and EPIC 245950175 systems finding that the semi-analytic approach works well in the former case but not so well in the latter case on account of the effects of three active three body Laplace resonances which persist during the evolution. For both systems we estimate that if the tidal parameter, $$Q',$$

Q
′

,

significantly exceeds 1000, tidal effects are unlikely to have influenced period ratios significantly since formation. On the other hand if $$Q' < \sim 100$$

Q
′

<
∼
100

tidal effects may have produced significant changes including the formation of three body Laplace resonances in the case of the EPIC 245950175 system.
Mitochondrial DNA Heteroplasmy as an Informational Reservoir Dynamically Linked to Metabolic and Immunological Processes Associated with COVID-19 Neurological Disorders
Authors: Stefano George B. , Kream Richard M. 
Published: June 2021

AbstractMitochondrial DNA (mtDNA) heteroplasmy is the dynamically determined co-expression of wild type (WT) inherited polymorphisms and collective time-dependent somatic mutations within individual mtDNA genomes. The temporal expression and distribution of cell-specific and tissue-specific mtDNA heteroplasmy in healthy individuals may be functionally associated with intracellular mitochondrial signaling pathways and nuclear DNA gene expression. The maintenance of endogenously regulated tissue-specific copy numbers of heteroplasmic mtDNA may represent a sensitive biomarker of homeostasis of mitochondrial dynamics, metabolic integrity, and immune competence. Myeloid cells, monocytes, macrophages, and antigen-presenting dendritic cells undergo programmed changes in mitochondrial metabolism according to innate and adaptive immunological processes. In the central nervous system (CNS), the polarization of activated microglial cells is dependent on strategically programmed changes in mitochondrial function. Therefore, variations in heteroplasmic mtDNA copy numbers may have functional consequences in metabolically competent mitochondria in innate and adaptive immune processes involving the CNS. Recently, altered mitochondrial function has been demonstrated in the progression of coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Accordingly, our review is organized to present convergent lines of empirical evidence that potentially link expression of mtDNA heteroplasmy by functionally interactive CNS cell types to the extent and severity of acute and chronic post-COVID-19 neurological disorders.
Cardiooncology—dealing with modern drug treatment, long-term complications, and cancer survivorship
Authors: de Wall Claudia , Bauersachs Johann , Berliner Dominik 
Published: June 2021

AbstractModern treatment strategies have improved prognosis and survival of patients with malignant diseases. The key components of tumor treatment are conventional chemotherapy, radiotherapy, targeted therapies, and immunotherapy. Cardiovascular side-effects may occur in the early phase of tumor therapy or even decades later. Therefore, knowledge and awareness of acute and long-lasting cardiac side effects of anti-cancer therapies are essential. Cardiotoxicity impairs quality of life and overall survival. The new cardiologic subspecialty ‘cardio-oncology’ deals with the different cardiovascular problems arising from tumor treatment and the relationship between cancer and heart diseases. Early detection and treatment of cardiotoxicity is of crucial importance. A detailed cardiac assessment of patients prior to administration of cardiotoxic agents, during and after treatment should be performed in all patients. The current review focusses on acute and long-term cardiotoxic side effects of classical cytotoxic and selected modern drug treatments such as immune checkpoint inhibitors and discusses strategies for the diagnosis of treatment-related adverse cardiovascular effects in cancer patients.