bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Complex” hepatic echinococcosis
Authors: Goncharov A. B. , Kovalenko Y. A. , Ayvazyan Kh. A. , Ikramov R. Z. , Marinova L. A. , Vishnevsky V. A. , Chzhao A. V. 
Published: December 2021

Aim. To study the long-term results of surgical treatment in patients with “complex” hepatic echinococcosis.Materials and methods. The results of surgical treatment of 118 patients with hepatic echinococcosis from 2015 to 2020 at the A.V. Vishnevsky National Medical Research Center of Surgery were analyzed. The term “complex” hepatic echinococcosis has been proposed. A comparative analysis of the number and type of complications and surgical interferences 2 groups of patients was carried out: 66 patients with hepatic echinococcosis, 52 patients with complex hepatic echinococcosis.Results. During the observation period, no any recurrence was recorded. 55 (44%) of 118 patients had complex hepatic echinococcosis. Isolated liver damage was found in 74% of cases, combined liver and lung damage in 20% cases and with other organs – in 6%. In most cases, pericystectomy was performed (82%), 8% of patients underwent atypical hepatectomy, 4% – segmental resection, 3% – laparoscopic intervention, 3% – hemihepatectomy. Postoperative complications were recorded in 22 (18,6%) of cases. Accumulations of bile and biliary fistulas formed in 45% of cases, pneumotothorax or hydrothorax – in 23%, wound abscess – in 18%, hematomas in the hepatectomy zone – in 14% of the cases.Conclusion. Surgical treatment of complex hepatic echinococcosis requires an individual approach to the choice of the operation option. Preference should be given to parenchyma-preserving radical operations. When the liver lobe is totally replaced with a hydatid cyst and in case of cystobiliary fistulas hemihepatectomy should be performed, and it is acceptable to leave the fibrous capsule on large tubular structures.
Optimization of surgical tactics in hepatic echinococcosis
Authors: Voskanyan S. E. , Naidenov E. V. , Bashkov A. N. , Cholakyan S. V. 
Published: December 2021

Aim. Optimization of the surgical tactics in hepatic echinococcosis.Material and methods. From 2009 to 2021, 56 patients with hepatic echinococcosis have been operated: 6 patients underwent PAIR, 7 – open echinococcectomy, 18 – pericystectomy (“ideal echinococcectomy”) and 16 – anatomical hepatectomy (S2/3, S6/7 bisegmentectomy) or atypical resection. In 7 cases hemigepatectomy has been performed, in 2 – combined interventions have been performed for echinococcosis relapse of the abdominal cavity.Results. The duration of minor hepatic resection was shorter than pericystectomy and major hepatic resection. The smallest blood loss was noted in patients who underwent open echinococcectomy, anatomical and atypical hepatectomy. No complications after PAIR were noticed. The lowest incidence of postoperative complications, including biliary complications, was found after hepatic resection interventions. The lenths of hospital stay after hepatic resections was significantly shorter compared to ecinococcectomy and pericystectomy. The reccurence of hepatic echinococcosis relapse was detected in 4 (66.7%) patients after PAIR and 2 (28.6%) patients after ecinococcectomy.Conclusion. Organ-preserving techniques should be a priority in the surgical treatment of hepatic echinococcosis. The best results in terms of the early postoperative complications frequency in the hepatic echinococcosis treatment were demonstrated by minor hepatic resections. Open echinococcectomy should be performed only for central location of large cysts and (or) their massive contact with the liver vessels. Minimally invasive resection technologies demonstrate optimal short- and long-term results. Major hepatectomy should be performed very selectively and only in those cases when they have advantages over other methods, and their implementation does not lead to a loss of more than 20% of healthy hepatic parenchyma. The best long-term results showed pericystectomy and hepatectomy in comparison with echinococcectomy.
Results of minimally invasive treatment of liver echinococcosis in comparison with traditional surgical methods
Authors: Nagasbekov M. S. , Baimakhanov Zh. B. , Kaniyev Sh. A. , Nurlanbayev E. K. , Chormanov A. T. , Baimakhanov B. B. 
Published: December 2021

Aim. To analyze the effectiveness of PAIR in comparison with traditional surgical methods.Materials and methods. A retrospective analysis of 199 patients who underwent surgical treatment of hepatic echinococcosis was carried out. Pericystectomy was performed on 95 (47.7%) patients (1st group), traditional echinococcectomy – 55 (27.6%; 2nd group), PAIR – 49 (24.6%; 3rd group). All patients received antihelmintic therapy for 2 months in the postoperative period.Results. Patients of the group 3 had significantly more CE1 cysts compared with the groups 2 and 1 – 38 (77.5%) versus 19 (34.5%) and 44 (46.3%; p < 0.05) respectively. In group 2, CE2 and CE3 cysts were predominant. The duration of the operation in group 3 was significantly shorter than in group 1 and 2 – 58.2 (25–170), 194.8 (85–440) and 217 (75–540) minutes (p < 0.05). In group 1, intraoperative blood loss was higher than in group 2 – 165.4 ml (10–1000) and 106.7 ml (10–500; p < 0.05). There were no statistically significant differences between the groups in postoperative complications according to Clavien–Dindo. The duration of postoperational hospital stay of patients from the group 3 was shorter than for 1 and 2 groups – 4.3 (2–11) days, 8.03 (5–16) days and 8.08 (4–20) days (p < 0.05) respectively. There was no disease recurrence during the follow-up period.Conclusion. The optimal treatment should be based on the stage of the disease. In CE1, the most effective method is PAIR, which is characterized by a shorter postoperational hospital stay and early recovery. In multivesicular cysts (CE2-CE3b), traditional methods of treatment are effective.
Laparoscopic and open operations in the treatment of hepatic echinococcosis. Analysis of short- and long-term results
Authors: Efanov M. G. , Pronina N. I. , Alikhanov R. B. , Melekhina O. V. , Kulezneva Y. V. , Kazakov I. V. , Vankovich A. N. , Koroleva A. A. , Kovalenko D. E. , Kulikova N. D. , Petrin A. M. , Tsvirkun V. V. 
Published: December 2021

Aim: to evaluate the short- and long-term outcomes of laparoscopic and open operations in the treatment of hepatic echinococcosis.Materials and methods. The results of laparoscopic and open echinococcectomies performed from 2013 to 2020 were retrospectively studied. Laparoscopic operations were considered the method of choice. Open operations were performed in cases with contraindications to the laparoscopic approach.Results. In total, 57 patients were operated: 47 laparoscopically (including robotic approach in 4 cases), 9 patients underwent open surgery. Radical procedures prevailed among laparoscopic cystectomies: 46 (98%). In the groups of laparoscopic/open cystectomies, partial pericystectomy was performed in 1/3 of patients, subtotal – in 24/4, total – in 13/0, and liver resection – in 9/2 patients, respectively. Laparoscopic procedures were performed mainly for types 1 and 3 of cysts, open procedures – for type 2 (WHO), recurrent and extrahepatic abdominal cysts were indication for open surgery. The frequency of severe complications did not differ between the groups. In the laparoscopic group, 1 (2%) patient died. After laparoscopic cystectomies, the mean (median) hospital stay (8 vs 10 days) and duration of abdominal drainage (10 vs 12 days) were significantly shorter. Relapse occurred only after conservative cystectomies, in one patient in each group.Conclusion. Laparoscopic radical surgery for liver hydatid cysts may be the method of choice if performed in a specialized HPB center. Patient selection criteria should be based on the center's experience in laparoscopic liver surgery.
Diagnostic criteria for spinal muscular atrophy 5q
Authors: Sharkova I. V. , Dadali E. L. , Nikitin S. S. 
Published: December 2021

Background. The variety of phenotypic manifestations of spinal muscular atrophy 5q (5qCMA) is the reason for the difficulty in diagnosing and delaying the diagnosis, which is of particular importance today due to the emergence of new etiopathogenetic therapeutic possibilities.Objective: determination of the main clinical features and symptoms of 5qCMA with onset at different age periods, and the development of an algorithm that can help in making decisions regarding the need for testing the SMN1 gene by primary care and hospital doctors.Materials and methods. A retrospective analysis of the case histories of patients observed at the Research Center of Medical Genetics with a confirmed diagnosis of 5qCMA was carried out.Results. The study included data from 315 patients, including: 173 with type I, 95 and 47 with types II and III 5qCMA. In all cases, the presence and diagnostic significance of 27 signs and symptoms were analyzed, depending on the age of disease manifestation. An attempt was made to isolate the main symptoms, which are the basis for the mandatory exclusion of 5qCMA by molecular genetic methods in patients with the onset of the disease before and after 18 months of life.
Three-Dimensional Seismic-Wave Propagation Simulations in the Southern Korean Peninsula Using Pseudodynamic Rupture Models
Authors: Lee Jaeseok , Song Jung-Hun , Kim Seongryong , Rhie Junkee , Song Seok Goo 
Published: December 2021

ABSTRACTAccurate and practical ground-motion predictions for potential large earthquakes are crucial for seismic hazard analysis of areas with insufficient instrumental data. Studies on historical earthquake records of the Korean Peninsula suggest that damaging earthquakes are possible in the southeastern region. Yet classical ground-motion prediction methods are limited in considering the physical rupture process and its effects on ground motion in complex velocity structures. In this study, we performed ground-motion simulations based on rigorous physics through pseudodynamic source modeling and wave propagation simulations in a 3D seismic velocity model. Ensembles of earthquake scenarios were generated by emulating the one- and two-point statistics of earthquake source parameters derived from a series of dynamic rupture models. The synthetic seismograms and the distributions of simulated peak ground velocities (PGVs) were compared with the observations of the 2016 Mw 5.4 Gyeongju earthquake in the Korean Peninsula. The effects of surface-wave radiation, rupture directivity, and both local and regional amplifications from the 3D wave propagation were reproduced accurately in the spatial distribution of simulated PGVs, in agreement with the observations from dense seismic networks by mean log residuals of −0.28 and standard deviations of 0.78. Amplifications in ground motions were found in regions having low crustal velocities and in regions of constructive interference from the crustal shear-wave phases associated with postcritical reflections from the Moho discontinuity. We extended the established approach to earthquake scenarios of Mw 6.0, 6.5, and 7.0, at the same location, to provide the distribution of ground motions from potential large earthquakes in the area. Although we demonstrate the value of these simulations, improvements in the accuracy of the 3D seismic velocity model and the scaling relationship of the source models would be necessary for a more accurate estimation of near-source ground motions.
Planning energy retrofits of historic buildings
Authors: Broström Tor , Buda Alessia , Herrera Daniel , Haas Franziska , Troi Alexandra , Exner Dagmar , Mauri Sara , Jan de Place Hansen Ernst , Marincioni Valentina , Vernimme Nathalie 
Published: December 2021

This handbook follows the systematic approach outlined by the European standard EN 16883:2017 Guidelines for improving the energy performance of historic buildings. It describes how the standard can be applied in practice with chapters on heritage value assessment, building survey and holistic assessment of energy efficiency measures. The book draws on the experience from a team of international leading experts in the field of energy efficiency in historic building.
Conservation compatible energy retrofit technologies: Part II: Documentation and assessment of conventional and innovative solutions for conservation and thermal enhancement of window systems in historic buildings
Authors: Exner Dagmar , Rose Jørgen , Héberlé Élodie , Mauri Sara 
Published: December 2021

The main objective of Subtask C is to identify, assess and in some cases further develop retrofit solutions and strategies for historic buildings. The solutions should fulfil the conservation compatibility of historic buildings as well as energy efficiency goals towards lowest possible energy demand and CO2 emissions (NZEB). Further, the objective is to make the solutions available for comprehensive integrated refurbishing concepts and strategies.
Human, Social, and Intellectual Capital in the COVID-19 Era: Establishing the Agenda. Framing, Plausibility, and Verifiability in the Repositories
Authors: García Lirios Cruz 
Published: December 2021

The health and economic crisis caused by the SARS CoV-2 coronavirus and the COVID-19 disease has accelerated the emergence of an informational economy focused on the use of electronic networks. The impact of this scenario on education led to the transition from the traditional classroom to the electronic whiteboard. The objective of the present work is to analyze the relationships between human, social, and intellectual capital. A model showing the prevalence of human capital creation—as indicated by data processing in the virtual class-room and self-management of knowledge—was established.
BERITA HOAKS DALAM TAFSIR RAWAIU`L BAYAN dan RELEVANSINYA di INDONESIA
Authors: Quran Jurnal Semiotika , Al-Haddad M. Yusuf 
Published: December 2021

Globalisasi di era digital dan perkembangan TIK (Teknologi Informasi dan Komunikasi) yang begitu pesat menjadikan informasi dan komunikasi semakin mudah dilakukan dan terus berkembang dalam skala yang sangat cepat dan besar. Dengan semakin berkembangnya teknologi saat ini, maka hal tersebut memiliki dua sisi layaknya mata pisau, di satu sisi bisa bersifat positif ketika digunakan untuk suatu hal yang benar, namun tidak dinafikan di sisi lain dapat bersifat negatif jika digunakan untuk hal yang salah.
Di antara sisi negatifnya adalah penyebaran informasi yang secara masif namun tidak didasari dengan fakta yang disebut dengan istilah hoaks. makna hoaks sebagaimana yang telah disebutkan oleh Ahli Tafsir Rawaiu’l Bayan Al-Tafsir Ayati Al-Ahkam Min Al-Qur`an karya Muhammad Ali Ash-Shabuni dalam tiga term yaitu: Al-Ifk, Al-Fasiq dan Al-Qazf. hoaks juga merupakan konspirasi untuk mengalahkan lawan atau musuh, dan juga sifat dari hoaks sendiri adalah berita yang cepat menyebar dan mampu mempengaruhi.
Kinematics and Geochronology of Late Paleozoic–Early Mesozoic Ductile Deformation in the Alxa Block, NW China: New Constraints on the Evolution of the Central Asian Orogenic Belt
Authors: Zhang Beihang , Zhang Jin , Zhao Heng , Qu Junfeng , Zhang Yiping , Niu Pengfei , Hui Jie , Yun Long 
Published: December 2021

Abstract
Strike-slip faults are widely developed throughout the Central Asian Orogenic Belt (CAOB), one of the largest Phanerozoic accretionary orogenic collages in the world, and may have played a key role in its evolution. Recent studies have shown that a large number of Late Paleozoic–Early Mesozoic ductile shear zones developed along the southern CAOB. This study reports the discovery of a NW–SE striking, approximately 500 km long and up to 2 km wide regional ductile shear zone in the southern Alxa Block, the Southern Alxa Ductile Shear Zone (SADSZ), which is located in the central part of the southern CAOB. The nearly vertical mylonitic foliation and subhorizontal stretching lineation indicate that the SADSZ is a ductile strike-slip shear zone, and various kinematic indicators indicate dextral shearing. The zircon U-Pb ages and the 40Ar/39Ar plateau ages of the muscovite and biotite indicate that the dextral ductile shearing was active during Middle Permian to Middle Triassic (ca. 269–240 Ma). The least horizontal displacement of the SADSZ is constrained between ca. 40 and 50 km. The aeromagnetic data shows that the SADSZ is in structural continuity with the coeval shear zones in the central and northern Alxa Block, and these connected shear zones form a ductile strike-slip duplex in the central part of the southern CAOB. The ductile strike-slip duplex in the Alxa Block, including the SADSZ, connected the dextral ductile shear zones in the western and eastern parts of the southern CAOB to form a 3000 km long E-W trending dextral shear zone, which developed along the southern CAOB during Late Paleozoic to Early Mesozoic. This large-scale dextral shear zone was caused by the eastward migration of the orogenic collages and blocks of the CAOB and indicates a transition from convergence to transcurrent setting of the southern CAOB during Late Paleozoic to Early Mesozoic.
Optimization of ‘On Farm’ Hydropriming Conditions In Wheat: Soaking Time And Water Volume Have Interactive Effects On Seed Performance
Authors: Tanwar Hemender , Mor Virender Singh , Sharma Sushma , Khan Mujahid , Bhuker Axay , Singh Vikram , Yadav Jitender , Sangwan Sonali , Singh Jogender , Yashveer Shikha , Singh Kuldeep 
Published: December 2021

Abstract
Seed priming is a simple and cost effective method to obtain a better plant stand under diverse environmental conditions. The current study was designed to determine the optimal priming duration and water volume for wheat seed. For this experiment, three wheat genotypes with distinct genetic and adaptive backgrounds were chosen. Seeds of each genotype were hydroprimed for 7 durations, i.e. 1, 2, 4, 8, 12, 16, and 20 hours, in three different water volumes, i.e. half, equal, and double volume with respect to seed weight. The control was unprimed (dry) seed. The germination characteristics and seedling vigour potential of hydroprimed seeds were evaluated in the lab by recording several parameters such as germination percentage and speed, seedling growth, and vigour indices at two different temperature levels. The results showed that optimal duration for hydropriming of wheat seed is 12 hours with an equal volume with respect to original seed weight, closely followed by 8 hours with double volume. Reduction in seed performance was observed at 16 and 20 hours priming particularly at double volume treatment. Effect of temperature on seed germination showed improvement in seedling vigour at 25°C when compared to 20°C, although germination percentage decreased slightly. Volume of water and priming duration showed significant interactive effects demonstrating that a higher volume can give equivalent results at a shorter duration and vice versa.
Inhibition of Angiogenesis and Tumor Progression of Mk-0429, an Integrin Αvβ3 Antagonist, on Oral Squamous Cell Carcinoma
Authors: Nakagawa Takayuki , Ohta Kouji , Naruse Takako , Sakuma Miyuki , Okuda Satoshi , Fukada Syohei , Yamakado Nao , Akagi Misaki , Sasaki Kazuki , Niwata Chieko , Ono Shigehiro , Takechi Masaaki , Aikawa Tomonao 
Published: December 2021

Abstract
PurposeIntegrin αvβ3 is an essential molecule for tumor angiogenesis. This study aimed to investigate the anti-tumor effect of MK-0429, an integrin αvβ3 antagonist, on oral squamous cell carcinoma (OSCC) through its inhibitory effect on angiogenesis.MethodsIn this study, we investigated the effect of MK-0429 on cellular function and angiogenesis in vitro with the use of an immortalized human umbilical vein endothelial cell, HUEhT-1, which is immortalized by the electroporatic transfection of hTERT. The effect of MK-0429 on the integrin αvβ3 signaling pathway was examined by FAK and ERK 1/2 phosphorylation. The anti-angiogenic effect of MK-0429 was evaluated by in vitro tube formation assay. The anti-tumor effect on OSCC was assessed by administrating MK-0429 to mouse oral cancer xenografts.ResultsMK-0429 inhibited cell proliferation, migration, and adhesion of HUEhT-1 in a dose-dependent manner. FAK and ERK phosphorylation were significantly blocked by MK-0429 treatment. Tube formation was suppressed by MK-0429 in dose-dependent manner. Tumor progression was significantly suppressed by MK-0429 administration in mouse oral cancer xenografts. Histological study revealed that MK-0429 decreased tumor vascularization.ConclusionThese results indicated integrin αvβ3 as a therapeutic target for OSCC and suggested that MK-0429 might be clinically applicable as an anti-tumor agent with potent antiangiogenic activity.
Reduction of Environmental Chemicals, Toxicity and Particulate Matter in Wet Scrubber Device to Achieve Zero Emissions
Authors: Ramaswamy Krishnaraj , Jule Leta Tesfaye , N Nagaprasad , subramanian Kumaran , R Shanmugam , L Priyanka Dwarampudi 
Published: December 2021

Abstract
When fine particles generated by the foundry industry are present in the atmosphere, they have an impact on the climate because of their influence on atmospheric radioactive phenomena. As a result of this scenario, there is a rising amount of legislation restricting the emission of pollutants from foundry industries and related businesses. In response to this situation, many researchers have concentrated on end-of-pipe technologies, one of which is the wet scrubber, which is a device that is primarily used in foundries to control pollution and is one of the devices that has been incorporated. The disadvantage of using this wet scrubber, on the other hand, is that it contributes to secondary pollution when it is used. In order to combat secondary pollution, a model of an enhanced wet scrubber system that incorporates a multi-sand filtering technology was developed. The performance of this redesigned wet scrubber system was evaluated with the use of computational fluid dynamics software. Because of the introduction of the filtration tank's computation, it was discovered that successful filtration was accomplished using sand filters, meaning that environmental chemicals and particles were totally filtered from 0.17 kg at the entrance to zero kg of particles at the outflow.
Single-cell Sequencing Resolves Landscape of Immune cell and Regulatory Mechanisms in HIV-infected immune non-responders
Authors: Li Haiyu , Wang Yujing , Li Yue , Yang Yi , Xia Yuxin , Liao Kui , Song Fangzhou , Deng Shixiong , chen yaokai 
Published: December 2021

Abstract
Immune non-responder (INR) after highly active antiretroviral therapy (HAART) is the main cause of opportunistic infection and high mortality in AIDS patients, but the mechanism underlying immune reconstitution failure is poorly understood. Here we performed scRNA-seq and scATAC-seq analysis of peripheral blood mononuclear cells (PBMCs) derived from Immune nonresponder (INR) and responder (IR) HIV-1-infected subjects. We then describe the mitochondrial function of MAIT by flow cytometry in INRs and IRs. We founded there were diminished frequencies and numbers of MAIT cells in INRs, and MAIT cells from INRs displayed transcriptional profiles associated with the impairment of mitochondrial function and apoptosis signaling. ScATAC-seq and flow cytometry revealed diminished mitochondrial fitness in MAIT cells from INRs, and MAIT had low expression of transcription factor A for mitochondria (TFAM) and PPARA. These findings demonstrate the restoring mitochondrial function could modulate the immune dysfunction characteristic of MAIT, which against bacterial co-infections in INRs subjects.