bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of inhibitor eradication by primary immune tolerance induction in severe haemophilia A with high responding inhibitors
Authors: Di Minno Giovanni , Coppola Antonio , Margaglione Maurizio , Rocino Angiola , Mancuso Maria Elisa , Tagliaferri Annarita , Linari Silvia , Zanon Ezio , Santoro Cristina , Biasoli Chiara , Castaman Giancarlo , Santagostino Elena , Mannucci Pier Mannuccio ,   the AICE PROFIT Study Group
Published: November 2021

AbstractBackgroundImmune tolerance induction (ITI) is the only proven strategy to eradicate factor VIII inhibitors in patients with haemophilia A (HA).AimTo identify patients and treatment options with the highest chance of inhibitor eradication by primary ITI.Patients and methodsIn the frame of the Italian ITI Registry, carried out from 1995 to 2015 (last follow‐up 2018), 137 primary ITI courses in severe HA patients (90/137 with poor prognosis) were analysed for predictors of outcome (complete/partial response or failure). Sixty‐six of them (48%) were prospectively evaluated.ResultsITI was successful in 91/137 patients (66.4%) and 70 (51.1%) achieved complete response within 11 months (median). Historical peak titres ≤200 BU/ml (P = .033), inhibitor titres ≤5 BU/ml at ITI start (P = .001), peak titres ≤100 BU/ml during ITI (P < .001) and missense mutations and small insertions/deletions of FVIII gene (P = .027) predicted complete inhibitor eradication. A score that considers the cumulative number of these variables predicted complete response with positive predictive values up to .81 at ITI start and .91 during ITI, respectively. Patients who had no bleeding (OR, 3.45, 95% CI: 1.4–8.6) nor other adverse events (OR 2.6, 95%CI: 1.3–5.3) during ITI had higher chances of complete response. During the 120‐month follow‐up (median), 2/70 patients who had achieved complete response relapsed (2.9%).ConclusionsThis Registry, with a centralized review of outcomes, homogeneous data collection (half of which prospective) and long‐term follow‐up, provides insights for optimizing ITI, with a rationale for further studies in the currently evolving scenario of inhibitor management in HA patients.
Epidemiology, investigation, management, and outcome of headache in emergency departments (HEAD study)—A multinational observational study
Authors: Kelly Anne Maree , Kuan Win Sen , Chu Kevin H. , Kinnear Frances B. , Keijzers Gerben , Karamercan Mehmet A. , Klim Sharon , Wijeratne Tissa , Kamona Sinan , Graham Colin A. , Body Richard , Roberts Tom , Horner Daniel , Laribi Said ,   and the HEAD Study Group
Published: November 2021

AbstractObjectiveTo describe the epidemiology of nontraumatic headache in adults presenting to emergency departments (EDs).BackgroundHeadache is a common reason for presentation to EDs. Little is known about the epidemiology, investigation, and treatment of nontraumatic headache in patients attending EDs internationally.MethodsAn international, multicenter, observational, cross‐sectional study was conducted over one calendar month in 2019. Participants were adults (≥18 years) with nontraumatic headache as the main presenting complaint. Exclusion criteria were recent head trauma, missing records, interhospital transfers, re‐presentation with same headache as a recent visit, and headache as an associated symptom. Data collected included demographics, clinical assessment, investigation, treatment, and outcome.ResultsWe enrolled 4536 patients (67 hospitals, 10 countries). “Thunderclap” onset was noted in 14.2% of cases (644/4536). Headache was rated as severe in 27.2% (1235/4536). New neurological examination findings were uncommon (3.2%; 147/4536). Head computed tomography (CT) was performed in 36.6% of patients (1661/4536), of which 9.9% showed clinically important pathology (165/1661). There was substantial variation in CT scan utilization between countries (15.9%–75.0%). More than 30 different diagnoses were made. Presumed nonmigraine benign headache accounted for 45.4% of cases (2058/4536) with another 24.3% classified as migraine (1101/4536). A small subgroup of patients have a serious secondary cause for their headache (7.1%; 323/4536) with subarachnoid hemorrhage (SAH), stroke, neoplasm, non‐SAH intracranial hemorrhage/hematoma, and meningitis accounting for about 1% each. Most patients were treated with simple analgesics (paracetamol, aspirin, or nonsteroidal anti‐inflammatory agents). Most patients were discharged home (83.8%; 3792/4526). In‐hospital mortality was 0.3% (11/4526).ConclusionDiagnosis and management of headache in the ED is challenging. A small group of patients have a serious secondary cause for their symptoms. There is wide variation in the use of neuroimaging and treatments. Further work is needed to understand the variation in practice and to better inform international guidelines regarding emergent neuroimaging and treatment.
Changes in migraine characteristics over 30 days of Ramadan fasting: A prospective study
Authors: Ragab Amany H. , Kishk Nirmeen A. , Hassan Amr , Yacoub Osama , El Ghoneimy Lobna , Elmazny Alaa , Elsawy Enji H. , Mekkawy Doaa , Othman Alshimaa S. , Rizk Hoda Ibrahim , Mohammad Mohammad Edrees , Shehata Hatem S. , Shalaby Nevin , Magdy Rehab 
Published: November 2021

AbstractObjectiveTo study Ramadan's effect on migraine from the start to the end of the month and the tolerability of patients with migraine to fasting.BackgroundFasting is a well‐known trigger for migraine. Whether this effect on migraine is the same throughout the whole month, or whether it varies from the first to the last days of the month, has not been studied yet.MethodsA prospective cohort observational study was carried out on persons with migraine who fasted from 24 April to 23 May during Ramadan 2020. Each patient was asked to fill out their headache diary starting from Shaaban (the month before Ramadan) to the end of Ramadan. The Ramadan diary was divided by 10 days each, by which the patient was asked to accurately describe their migraine attacks in terms of frequency, duration, and intensity by using the Visual Analog Scale. Migraine attacks during the first day of fasting were assessed separately.ResultsA total of 292 known persons with migraine from Egypt completed the study. Their median age was 33 years; 72/292 (24.7%) were male, and 220/292 (75.3%) were female. About 126/236 (53.4%) of the patients had migraine attacks on Ramadan's first day, most of them during fasting. The frequency of migraine attacks was significantly increased in Ramadan (median 4, interquartile range [IQR] 2–7) compared with Shaaban (median 3, IQR 1–6), p = 0.009. The number of attacks was significantly reduced in both the second (median 1, IQR 0–2.25) and the third 10 days of Ramadan (median 1, IQR 1–3) compared with the first 10 days (median 3, IQR 1–5) (p < 0.001 for each).ConclusionRamadan's potential exacerbating effect on the frequency of migraine attacks should be discussed with patients with migraine. This effect appears to be limited to the first 10 days of Ramadan and then subsides with successive days of fasting.
SRY‐box transcription factor 10 is a highly specific biomarker of basal‐like breast cancer
Authors: Klaric Kristina‐Ana , Riaz Nazia , Asleh Karama , Wang Xiu Qing , Atalla Tadros , Strickland Sarah , Nielsen Torsten O , Kos Zuzana 
Published: November 2021

AimsBasal‐like breast cancer is an aggressive molecular subtype associated with younger age and early relapse. Most cases lack expression of oestrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2, limiting targeted therapeutic options. Basal‐like breast cancer is defined by the expression of genes in the outer/basally located epithelial layer of mammary glands, including those encoding cytokeratin (CK) 5 and CK14, and epidermal growth factor receptor (EGFR). SRY‐box transcription factor 10 (SOX10), for which there is a readily available immunohistochemical stain, is expressed in a subset of breast cancers, particularly triple‐negative carcinomas. In this study, we sought to: (i) assess the association between SOX10 expression and intrinsic molecular subtypes as defined by Prediction Analysis of Microarray 50 (PAM50) gene expression; and (ii) compare the performance of SOX10 with that of other surrogate markers of the basal‐like subtype, including CK5, EGFR, nestin, and inositol polyphosphate 4‐phosphatase type II (INPP4B).Methods and resultsSOX10 immunostaining was performed on tissue microarrays constructed from a contemporary series enriched for ER‐negative and weakly ER‐positive cancers that had also undergone PAM50 gene profiling. A total of 211 cases were informative for both SOX10 immunohistochemistry and PAM50 subtype, including 103 basal‐like cancers. Staining for SOX10 was positive in 73 of 103 basal‐like cancers and in only two of 108 cancers of other subtypes (P < 0.001), resulting in a sensitivity of 70.9% and a specificity of 98.1%. SOX10 was more specific than the other tested basal markers, and the results were independent of ER status.ConclusionsSOX10 is a moderately sensitive, but highly specific, immunohistochemical biomarker for the basal‐like intrinsic subtype of breast cancer, which, unlike other commonly used immunohistochemical biomarkers, is independent of hormone receptor status.
Online value co‐creation activities in three management domains: The role of climate and personal needs
Authors: Chen Aihui , Jin Yu , Xiang Mengqi , Lu Yaobin 
Published: November 2021

AbstractCustomers' online value co‐creation activities can occur the whole management domain (i.e., product design, marketing, and customer relationship management) of a product. Previous studies have researched value co‐creation from different angles, customers' online value co‐creation activities are more complex and its formation mechanism still worth exploring. Online communities need to create different environments according to different management fields to stimulate customers to participate in Online Value Co‐creation activities. Existing research confuses different value co‐creation activities in the entire management field without considering the different antecedents of Online Value Co‐creation activities in different situations and different management domains. The purpose of this paper is to explore the formation mechanism behind customers' online value co‐creation activities during the whole management domain. Drawing on social learning theory, this study examines the influential role of environmental factors (i.e., innovation climate and social climate) of online communities and personal need factors (i.e., brand passion, satisfaction, dissatisfaction, and desire for control) on customers' value co‐creation activities in the three fields of the management domain. Empirical analyses in this study reveal that these factors play different roles in shaping value co‐creation activities in the three fields. The findings enrich our understanding of customers' value co‐creation activities in online communities and offer a broadened view of the value co‐creation framework and climate theory. Understanding the factors that motivate consumers to engage in co‐creation activities in different management domain enables firms to strategically manage their co‐creation relationships and innovation processes.
Evaluation of recurrent selection for drought tolerant tall fescue (Festuca arundinacea) using rain‐out shelters
Authors: Qu Yuanshuo , Green Edwin J. , Bonos Stacy A. , Meyer William A. 
Published: November 2021

AbstractRain‐out shelters provide an effective tool to establish controlled water‐stress environments by excluding undesired rain events and have been widely used in the selection and breeding of cool‐season turfgrass for improved drought tolerance. However, the efficiency of recurrent selection using rain‐out shelters has seldomly been investigated. In this study, we documented the selection process of tall fescue in one cycle of recurrent selection, compared the drought tolerance of two consecutive generations and estimated selection gain of tall fescue using rain‐out shelters. Depending on days of drought, relative selection gain ranges from −4.20% to 3.60%, indicating small and unstable improvement from the parental generation. A subsequent analysis of experimental data using Bayesian mixed linear model revealed low narrow‐sense heritability estimations (0.18 for parental generation and 0.08 for progeny generation), providing an explanation for this observation.
Compensating the socioeconomic achievement gap with computer‐assisted instruction
Authors: Chevalère Johann , Cazenave Loreleï , Berthon Mickaël , Martinez Ruben , Mazenod Vincent , Borion Marie‐Claude , Pailler Delphine , Rocher Nicolas , Cadet Rémi , Lenne Catherine , Maïonchi‐Pino Norbert , Huguet Pascal 
Published: November 2021

AbstractBackgroundAs educational digital technologies are increasingly being used in schools, past research left unanswered the question of these technologies' impact on the socioeconomic achievement gap even when equal access is guaranteed.ObjectivesThe objectives of the present study are to examine whether and how the socioeconomic achievement gap can be reduced through the use of computer‐assisted instruction (CAI).MethodsWe addressed this issue experimentally by comparing CAI to conventional teacher‐led classroom instruction with more than 800 middle and high school students from disadvantaged and highly privileged socioeconomic backgrounds in a range of topics.Results and ConclusionsBoth disadvantaged and highly privileged students taught with CAI outperformed those taught with conventional instruction, thus maintaining the socioeconomic achievement gap constant. However, we also found that disadvantaged students receiving CAI performed as well as highly privileged students receiving conventional teacher‐led instruction.TakeawaysThe positive effects associated with CAI may therefore help compensate the difficulties of students with a disadvantaged background, a still neglected possibility.
Assessing fidelity of implementation to a technology‐mediated early intervention using process data
Authors: Helsabeck Nathan P. , Justice Laura M. , Logan Jessica A. R. 
Published: November 2021

AbstractBackgroundProcess data, data generated by a user's interaction with a web‐based application, is an emerging tool in educational research. The current study explores using process data as a measure of implementation fidelity to a randomized control trial (RCT) of the Read It Again Mobile (RIA‐M) curricular supplement.ObjectivesTo determine the extent to which teachers implemented RIA‐M and to assess the utility of using process data in the assessment of fidelity.MethodsThe RCT involved 30 pre‐kindergarten classrooms with a sample of n = 216 students. RIA‐M provides a curricular supplement which teachers may incorporate into classroom instruction and is delivered via a tablet computer. Pre and post literacy assessments are used to determine treatment effect. Process data, produced from teacher interactions with the tablet, and classroom observations are used to assess fidelity.Results and ConclusionsOur findings indicate no difference between treatment and control students in the RCT. Yet, we find that process data provides unique fidelity information concerning treatment exposure, adherence, and quality of program delivery. Specifically, process data indicated that teachers did not demonstrate the same level of fidelity that was captured in classroom observations. This finding provides some evidence for the absence of an intervention effect.Major TakeawaysThe current study improves our understanding of how web‐based interventions may be assessed for implementation fidelity using process data. Further, process data offers a potentially reliable and scalable measure of fidelity for other web‐based educational interventions.
Quality improvement strategies enhance primary care dietetics: A systematic review and meta‐analysis
Authors: Kirkegaard Amy , Ball Lauren , Mitchell Lana , Brickley Bryce , Williams Lauren T. 
Published: November 2021

AbstractBackgroundQuality improvement strategies have been widely applied in health care; however, little is known about their use in primary care dietetics. This review aims to describe and evaluate the effectiveness of quality improvement strategies that seek to improve patient outcomes by enhancing dietetic care compared to standard dietetic care.MethodsThe study employed a systematic review and meta‐analysis design following PRISMA guidelines and included studies up to March 2021. Studies were included if they used a randomised controlled trial (RCT) design to evaluate the effect of a quality improvement strategy applied to care delivered by a dietitian on patient outcomes. A meta‐analysis was conducted where there were sufficient studies with homogeneous populations and outcome measures.ResultsTwelve RCTs (n = 1604) met the inclusion criteria for review and five studies (n = 511) were eligible for meta‐analysis for glycated haemoglobin in patients with type 2 diabetes. The most frequently reported quality improvement strategies addressed disease management programs (58%), patient education (67%), group care (42%) and patient self‐management (42%). A positive intervention effect was reported in 50% of the included studies. A low grade of evidence supported a positive intervention effect for quality improvement intervention by a dietitian for glycated haemoglobin (pooled mean difference = −0.39% with 95% confidence interval = −0.70 to −0.08, p = 0.01) in n = 511 patients with type 2 diabetes mellitus.ConclusionsInterventions aimed at enhancing quality in primary care dietetic practice support improvements in patient outcomes. Further research on quality improvement interventions for patient outcomes is required to strengthen the evidence base in this important topic.
OsRLR4 binds to the OsAUX1 promoter to negatively regulate primary root development in rice
Authors: Sun Chendong , Li Dongming , Gao Zhenyu , Gao Lei , Shang Lianguang , Wang Mei , Qiao Jiyue , Ding Shilin , Li Chuanyou , Geisler Markus , Jiang Dean , Qi Yanhua , Qian Qian 
Published: November 2021

AbstractRoot architecture is one of the most important agronomic traits that determines rice crop yield. The primary root (PR) absorbs mineral nutrients and provides mechanical support; however, the molecular mechanisms of PR elongation remain unclear in rice. Here, the two loss‐of‐function T‐DNA insertion mutants of root length regulator 4 (OsRLR4), osrlr4‐1 and osrlr4‐2 with longer PR, and three OsRLR4 overexpression lines, OE‐OsRLR4‐1/‐2/‐3 with shorter PR compared to the wild type/Hwayoung (WT/HY), were identified. OsRLR4 is one of five members of the PRAF subfamily of the regulator chromosome condensation 1 (RCC1) family. Phylogenetic analysis of OsRLR4 from wild and cultivated rice indicated that it is under selective sweeps, suggesting its potential role in domestication. OsRLR4 controls PR development by regulating auxin accumulation in the PR tip and thus the root apical meristem activity. A series of biochemical and genetic analyses demonstrated that OsRLR4 functions directly upstream of the auxin transporter OsAUX1. Moreover, OsRLR4 interacts with the TRITHORAX‐like protein OsTrx1 to promote H3K4me3 deposition at the OsAUX1 promoter, thus altering its transcription level. This work provides insight into the cooperation of auxin and epigenetic modifications in regulating root architecture and provides a genetic resource for plant architecture breeding.
Family burden of hospital‐managed pediatric atopic dermatitis: A nationwide registry‐based study
Authors: Vittrup Ida , Droitcourt Catherine , Andersen Yuki M. F. , Skov Lone , Egeberg Alexander , Delevry Dimittry , Fenton Miriam C. , Thyssen Jacob P. 
Published: November 2021

AbstractBackgroundParents of children with atopic dermatitis (AD) report reduced quality of life and higher stress level, which could increase risk of psychiatric and pain disorders, and medication use.MethodsBy use of Danish national registries, we identified family members of all first‐born Danish children born between 1 January 1995 and 31 December 2013 with a hospital diagnosis of AD, matched them 1:10 with family members of children without AD, and followed the cohorts over time.ResultsMothers of children with hospital‐managed AD had higher risk of filling a prescription for medications for depression, anxiety, pain and sleep problems, and of consulting a psychologist, but most associations disappeared after full adjustment. Siblings had higher risk of receiving a diagnosis for adjustment disorder, and fathers showed increased risk of filling a prescription for pain medication and of divorce, in crude but not adjusted models.ConclusionsThe increased risk of study endpoints seen in mothers of children with hospital‐managed AD was not explained by pediatric AD alone. Rather, the total burden in these families including parent and child morbidity and socioeconomic resources seems to explain these observations. The burden in families of children with AD may potentially affect the overall management of their child's AD.
Religion and Nonviolent Movements: The Catholic Church’s Influence on Chilean Resistance
Authors: Edmonds Amy E. 
Published: November 2021

AbstractThis study examines the relationship between religion and nonviolent resistance. I assess the influence of the Catholic Church in Chile on the nonviolent opposition to the Pinochet‐led military regime by producing a systematic account of the Church’s contribution to twelve factors necessary for successful nonviolent movements. The Church’s role was the most crucial in that it provided organizational strength and resources, delegitimized the opponent’s strategy for consolidating control, and helped formulate objectives for the opposition. The role of the Catholic Church in opposing the Pinochet regime in Chile provides an instructive case study of the influential and determinative role religious institutions can play in the outcomes of nonviolent social movements.
Nurse‐driven early rehabilitation protocol for critically ill children
Authors: Chaiyakulsil Chanapai , Thippanate Panitnard 
Published: November 2021

AbstractBackgroundPhysical impairment is a major morbidity in children surviving intensive care. The main objective of this study was to evaluate the effectiveness of a nurse‐driven protocol in the early mobilization of critically ill children in terms of reduction of motor dysfunction, pediatric intensive care unit stays, and ventilator days. The secondary objective was to evaluate safety, in terms of injury, dislodgement of medical devices, and cardiorespiratory instability attributable to the intervention.MethodsThe early rehabilitation intervention was initiated in July 2020. This retrospective interrupted time‐series study was divided into the pre‐implementation phase (January–June 2020) and the post‐implementation phase (July–December 2020). The motor function domain of the Functional Status Scale was used to define the motor dysfunction after pediatric intensive care unit discharge.ResultsTwenty‐five children were allocated in each group. The median age of the whole cohort was 11.5 months and approximately 58% of the population was male. The baseline characteristics of both groups were not statistically significant. There was a statistically significant reduction in motor dysfunction after protocol implementation (64.0% vs 36.0%; P = 0.044) with an absolute risk reduction of 28%. The number needed to treat was 3.6 children. There were no statistically significant differences in the median ventilator days, length of stay in the intensive care unit, and hospital length of stay. No complications were found.ConclusionsA nurse‐driven protocol for the early mobilization of critically ill children was feasible and could be effective in reducing post‐intensive care motor dysfunction.