bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum FGF21 levels are altered with various factors including lifestyle behaviors
Authors: Nakanishi Kaori , Ishibashi Chisaki , Ide Seiko , Yamamoto Ryohei , Nishida Makoto , Nagatomo Izumi , Moriyama Toshiki , Yamauchi-Takihara Keiko 
Published: September 2021

Abstract
Fibroblast growth factor (FGF) 21 has various functions, including glucose and lipid metabolism, yet the biology of FGF21 remains unclear. This study aimed to investigate specific conditions that might affect the functions of FGF21. Subjects included 398 healthy men who underwent health examinations to obtain information on physical and biochemical parameters and lifestyle behaviors. Associations of serum FGF21 levels with each parameter were assessed in the study. FGF21 levels correlated with age, body mass index, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure, aspartate aminotransferase, alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GTP), uric acid, total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, and HbA1c. Moreover, FGF21 levels were significantly associated with lifestyle behaviors, including smoking status and breakfast and alcohol consumption frequency. Multivariable regression analysis showed that age, ALT, γ-GTP, smoking status, and breakfast and alcohol consumption frequency were independent variables for FGF21 levels. Assessment among the non-obese and obese groups showed that FGF21 levels correlated with WC, SBP, and TC only in the non-obese group. Thus, serum FGF21 levels were affected by several factors, including lifestyle behaviors, age, and liver function. To assess the functions of FGF21 in individuals, considering these factors would be essential. (199 words)
Adenomyosis is an independent risk factor for complications in deep endometriosis laparoscopic surgery
Authors: Gracia Meritxell , de Guirior Cristian , Valdés-Bango Marta , Rius Mariona , Ros Cristina , Matas Isabel , Tortajada Marta , Martínez-Zamora María Ángeles , Quintas Lara , Carmona Francisco 
Published: September 2021

Abstract
Background

Deep endometriosis (DE) occurs in 15–30% of patients with endometriosis and is associated with concomitant adenomyosis in around 49% of cases. There are no data about the effect of the presence of adenomyosis in terms of surgical outcomes and complications. Thus, the aim of the present study was to evaluate the impact of adenomyosis on surgical complications in women with deep endometriosis undergoing laparoscopic surgery.
Methods

A retrospective cohort study including women referred to the endometriosis unit of a referral teaching hospital. Two expert sonographers preoperatively diagnosed DE and adenomyosis. DE was defined according to the criteria of the International Deep Endometriosis Analysis group. Adenomyosis was considered when 3 or more ultrasound criteria of the Morphological Uterus Sonographic Assessment group were present. Demographical variables, current medical treatment, symptoms, DE location, surgical time, hospital stay and difference in pre and post hemoglobin levels were collected. The Clavien-Dindo classification was used to assess surgical complications, and multivariate analysis was performed to compare patients with and without adenomyosis.
Results

157 DE patients were included into the study; 77 (49.05%) had adenomyosis according to transvaginal ultrasound (TVS) and were classified in the A group, and 80 (50.95%) had no adenomyosis and were classified in the noA group. Adenomyosis was associated with a higher rate of surgical complications: 33.76% (A group) vs. 12.5% (noA group) (p < 0.001). Multivariate analysis showed a 4.56-fold increased risk of presenting complications in women with adenomyosis (CI: 1.9–11.3; p = 0.001) independently of undergoing hysterectomy. There was a statistically significant association between the number of criteria of adenomyosis present in each patient and the proportion of patients presenting surgical complications (p < 0.001).
Conclusions

Adenomyosis increases the risk of presenting complications in DE surgery after controlling for demographic, clinical and surgical factors and should be considered an independent preoperative risk factor of surgical complications.
Presence of Lipid Vacuoles in Kupffer Cells as a Marker for Early Detection of Niemann-Pick Disease Type C in Neonatal Cholestasis
Authors: Wang Neng-Li , Chen Lian , Lu Yi , Xie Xin-Bao , Lin Jing , Abuduxikuer Kuerbanjiang , Wang Jian-She 
Published: September 2021

Abstract
Background

Early diagnosis of Niemann-Pick disease type C (NP-C) is the key for reduction of organ damage since a medical treatment is available now. However, early detection of patients with a high clinical suspicion of NP-C in neonatal cholestasis is still challenging. Plasma oxysterol studies demonstrate a relatively low specificity for NP-C in neonatal cholestatic patients. This study explores the significance of lipid vacuoles in Kupffer cells for early detection of NP-C in neonatal cholestasis.
Results

Between January 2018 and December 2020, 168 neonatal cholestatic patients with unexplained causes were underwent both liver biopsy and genetic tests, and 26 detected lipid vacuoles in Kupffer cells by CD68 staining. NP-C was diagnosed in 6 out of the 26 patients (23.1%), comparing to none of the remaining 142 neonatal cholestatic patients without vacuolar Kupffer cells (P < 0.001). In neonatal cholestatic patients with vacuolar Kupffer cells plus splenomegaly, the ratio of positive diagnosis of NP-C was 31.6% (6/19). Between January 2015 and December 2017, 3 additional NP-C patients were diagnosed. Of them, 1 patient underwent liver histologic studies also revealing lipid vacuoles in Kupffer cells. The 7 NP-C patients underwent liver biopsy at ages ranging from 35 to 112 days. Lipid vacuoles were only detected in a few Kupffer cells in the early disease course (about 1 month of age). The amount of vacuolar Kupffer cells increased with age, and the size became enlarged. Typical foam cells were only observed in HE sections of liver tissues obtained beyond 3 months of age when enlarged Kupffer cells with lipid vacuoles became obvious. In addition, 4 out of the 9 NP-C patients had fasting hypoglycemia.
Conclusions

Lipid vacuoles in Kupffer cells from liver biopsy can serve as a screening marker for early detection of NP-C in neonatal cholestasis.
Experiencing the Unprecedented COVID-19 Lockdown: Abu Dhabi Older Adults’ Challenges and Concerns
Authors: Badri Masood , Khaili Mugheer Al , Dhaheri Hamad Al , Yang Guang , Rashdi Asma Al , Alhyas Lyla 
Published: September 2021

Abstract
This study focused on older adults (60 + years old) in Abu Dhabi during the COVID-19 pandemic before vaccines were made available to them. They faced more strict rules of movement restriction and isolation that might have resulted in certain psychological feelings and social reactions. Data were gathered through an online survey of community members conducted from April to July of 2020, in which 574 older adults responded. The main objective was to understand Abu Dhabi older adults’ main psychological feelings during the pandemic and to identify their main concerns and challenges considering the various COVID-19 related policies and restrictions. The influence of the pandemic on older adults’ health and weight was also investigated. Results of descriptive analyses show that some negative psychological feelings were common among older adults’ during the pandemic. However, the psychological feelings did not portray significant changes with time, except for sleeping disorders and overeating. The movement restrictions imposed on elderlies and not being able to see children and grandchildren when wanted were the two main concerns reported. The research summaries some policy guidance while noting some limitations of this study and future research directions.
A trusted approach for prediction of data link failure and intrusion detection in wireless sensor networks
Authors: Srivi Putty , Devi Lavadya Nirmala , A Nageswar Rao 
Published: September 2021

Abstract
Typically, wireless senor network (WSN) is widely used in the various fields for several applications. It is a promising technology due to its higher range of the network connectivity and the fast set up of the network. But there will also be a presence of the some of the eradicating issues which will decrease the network growth. In the WSNfield the prediction of link failure is regarded as the baffling one till now. The proposed technique offers a detailed idea on the failure of link. The proficient trusted Node ID dependent resource reservation protocol (PTN-RRP) is presented in this approach. In this, the shortest path is then recognized with the use of approach weighted based end-to-end delay. This technique identifies the shortest path from a specific preliminary position to the target and thus could enhance the detectionrate. By means of recognizing shortest path, the hop address and sequence numeral is being incorporated to the protocol. Once afterwards the shortest pathdetection, the failure of link is estimated. A link failure structure in the trusted etiquetteemployed has the developedcapabilityto predict and fix issues related to link failure. After that, to identify the attack cause intended for the failureof link, a method of posterior probability evaluation is carried out to find the kind of attack. Finally, the proposed method performance isassessedover simulation study. The simulation outcomeauthorizes that the projectedmethod is effective highly in the link breakage detectionand the implemented algorithm for shortest path recognition in this will decreases the detecting shortest path time period. The performance outcome is compared with existing techniques to prove the effectiveness of proposed methodology.
Understanding the attitudes towards mental illness among graduate students at a small midwestern religious college
Authors: Grodsky Jennifer , Bittner Kendra , Alvarado Shara 
Published: September 2021

Abstract
Objective: To describe college students’, specifically health care professionals in-training, attitudes towards individuals diagnosed with mental illness. Participants: Graduate students (n=214) at a small midwestern college. Sixty-two percent enrolled in community psychology; 38% in nursing; and 30% from other graduate programs. Almost all were female (97%) and white (70%).Methods: A cross-sectional electronic survey designResults: Community psychology students had significantly more empathy towards individuals with mental illness then other graduate students (p<0.05). Other graduate students (p=0.04) and nursing students (p=0.010) had significantly more acceptance toward deinstitutionalization as compared to community psychology students. Those who indicated higher levels of individual knowledge and personal experience with mental illness had less stigma and pessimistic attitudes (p<0.05). Conclusions: Health care professionals in-training have underlying stigma regarding individuals diagnosed with mental illness. It is imperative for our institutions of higher learning to provide educational opportunities to help decrease this stigma.
Patient children are less likely to share with unknown children
Authors: Barragan-Jason Gladys , Hopfensitz Astrid 
Published: September 2021

Abstract
Human prosociality is a valuable but also deeply puzzling trait. While several studies suggest that prosociality is an instinctive and impulsive behavior, others argue that patience and self-control are necessary to develop prosocial behaviors. Yet, prosociality and patience in children have rarely been studied jointly. Here, we measured patience (i.e. delay-of-gratification) and prosociality (i.e. giving in a dictator game to a known or unknown partner) in 250 4- to 6-year-old French schoolchildren. We found that sharing with an unknown partner was negatively linked to patience in children but observed no relationship between patience and sharing with a familiar partner. Taken together, our results support the hypothesis that children are intuitively prosocial independent of strategic concerns and that patience is therefore not necessary to act prosocially during early childhood. Future studies investigating whether and why prosociality show a non-linear developmental trajectory across the lifespan are warranted.
Certain chorioretinal parameters of the eye in congenital and acquired myopia and their relationship with anatomical and optical parameters
Authors: Tarutta E. P. , Khubieva R. R. , Markosyan G. A. 
Published: September 2021

Purpose: to assess the thickness of the central region of the retina and choroid, the layer of nerve fibers in the macular and peripapillary regions, the density of the superficial and deep plexus of the retina and the choroid in congenital and acquired myopia and see how they are related with the refraction and axial length of the eye.Material and methods. 33 patients aged 6 to 16 (averagely, 12.07 ± 3.09 years) were divided into 3 groups: 1) with congenital myopia (23 eyes), 2) with acquired myopia (9 eyes), and 3) the control group with emmetropia (20 eyes). Chorioretinal and hemodynamic parameters were determined using an RS-3000 Advance 2 spectral optical coherence tomograph (Nidek, Japan). Correlation analysis was performed using Pearson’s linear correlation coefficient (r).Results. Structural changes in the sensory and vascular membranes of the eye were revealed in both myopic groups as compared to the control group. Of the two clinical groups, more severe structural disorders were found in congenital myopia. Hemodynamic parameters revealed abnormalities in the deep retinal layers, as well as in the choriocapillary layer. The comparative analysis showed that morphological changes in the posterior pole have a stronger correlation with anatomical parameters as compared to optical ones.Conclusion. Optical coherence tomography is an informative method of differential diagnosis, monitoring, and prognostication of changes in the posterior pole in myopia.
“Messages of Love from Maoriland”: A. D. Willis’s New Zealand Christmas Cards and Booklets 1883-1893
Authors: Gilderdale Peter 
Published: September 2021

I have previously explored the beginnings of the New Zealand Christmas card prior to 1883, and the ways that the designers of these cards negotiated the colonial experience of a summer Christmas.1 This paper examines the development, over the decade following 1883, of the chromolithographic work of A. D. Willis, whose production not only continued the work of creating a niche for New Zealand Christmas cards, but also tried to compete with the large overseas ‘art publishers’ who were flooding the New Zealand market with northern hemisphere iconography. Willis’s Christmas cards are frequently used to illustrate books looking at the 1880s, but there has been no detailed study done of them. The paper therefore documents the cards, their production and reception, explores how they record Willis’s understanding of the art publishing business and the market he was working into, and situates them in relation to broader print culture. Understanding this overlooked chapter in ‘commercial art’ provides useful evidence of the murky interplay between the local, national and transnational identities that marked New Zealand cultural production when artists and designers sought to capture the public’s Yuletide sentiments. Willis’s work also displays two very distinct conceptions of how to represent what was increasingly known as ‘Maoriland’ to an overseas market – one focused on the land, and the other on Māori. As such, these cards act as a weathervane for what the New Zealand public accepted as New Zealand, artistic and appropriate as a Christmas gift.
Colon Cancer in Patients with Crohn’s Disease and Diabetes Mellitus
Authors: Catalin Popescu Razvan , Nicoleta Leopa , Gentiana Micu Luminita , Ovidiu Costea Daniel , Minodora Olteanu Cornelia , Florin Ciobanu , Andrei Dumitru 
Published: September 2021

Abstract
Introduction: Diabetes mellitus and colorectal cancer are diseases with an increasing impact on the population. Colorectal cancer is a well-recognized complication of inflammatory bowel diseases, such as ulcerative colitis and Crohn’s colitis. Here we describe an unusual case of diabetes mellitus, Crohn`s colitis-associated cancer.
Case report: We report the case of a 49-year-old woman, known with Crohn's disease and diabetes, who developed a transverse colon adenocarcinoma associated with multiple outbreaks of high-grade or low-grade intraepithelial dysplasia/neoplasia, for which a subtotal proctocolectomy with ileorecto-anastomosis with “J” pouch it was made.
Conclusions: The risk of colonic carcinoma in Crohn's disease is increasing. An association of colorectal cancer with diabet mellitus and inflammatory bowel disease has been established. From diagnosis to treatment the management of these cases can be difficult and challenging.
Device and Algorithm for Vehicle Detection and Traffic Intensity Analysis
Authors: Gorobetz Mikhail , Potapov Andrey , Korneyev Aleksandr , Alps Ivars 
Published: September 2021

AbstractTo effectively manage the traffic flow in order to reduce traffic congestion, it is necessary to know the volumes and quantitative indicators of this flow. Various detection methods are known for detecting a vehicle in a lane, which, in turn, have their own advantages and disadvantages. To detect vehicles and analyse traffic intensity, the authors use a pulse coherent radar (PCR) sensor module. Testing of various modes of operation of the radar sensor was carried out to select the optimal mode for detecting vehicles. The paper describes a method for fixing vehicles of different sizes, filtering and separating the vehicle from the traffic flow. The developed vehicle detection device works in conjunction with signal traffic lights, through which traffic control takes place. The signal traffic lights, which have their own sensors and control units, communicate with each other via a radio channel; there is no need for cable laying. The system is designed to work on road maintenance sites. The paper describes the experimental data when testing on a separate section of the road. The experiment showed the advantage of traffic lights (cars passed the regulated traffic light faster) from the point of view of calculating the traffic flow over the normal traffic light operation. Reducing downtime in traffic jams, in turn, has a beneficial effect on the environmental situation, since at the moment internal combustion engines prevail in vehicles.
Automatic buildings detection using Sobel, Roberts, Canny and Prewwitt detector
Authors: Ladányi Libor , Králik Martin 
Published: September 2021

Abstract
This work deals with the possibilities of contemporary automatic identification of objects. Automatic object identification can be done by two computational procedures, namely object detection and object recognition. This work deals with the automatic buildings detection, specifically. Presented detection is performed using the edge detectors, namely Prewwitt, Roberts, Canny and Sobel. The main goal of our work was to automate the device for the detection of hazardous substances in the air, as the detection of hazardous substances is realized by laser-based CBRN (Chemical, Biological, Radiological and Nuclear) stand-off detectors, which evaluate the measured data from the reflected laser beam. In this case, buildings are the most reflective surfaces. In order to detect a building, it is necessary to find a suitable edge detector to be used in further research and serve as a basis for software solution of automatic identification.
Factors Releated To Community Behavior In Preventing Dengue Fever With 3M Plus In The Work Area Of The Harapan Raya Community Health Center In 2020
Authors: Rossa Rossa anugerah putri , Dewanto Hoppy , Sari Nila Puspita 
Published: September 2021

Dengue fever is an acute an endemic disease caused by dengue virus that is transmitted by aegypti mosquito in urban areas and in rural areas of aedesalbopictus.Who ( 2015 ) % 2,5 billion or 40 percent of the population in the world at risk of dengue fever living chiefly in tropical and subtropical regions. in the work Puskesmas Harapan Raya obtained 182 case in the last years, Found a kind of water body in a state of open garbage and, like a bottle plastic, former canscontaining a puddle where The aedes aegyptimosquito. Research aims to understand the factors that relating to the behavior of the people in the prevention of dengue fever case with 3M Plus in the work area of Puskesmas Harapan Raya 2020. A method of this research is Analytic observational with the design cross sectional and use test chi square. This study was conducted in august 2020, This is all subject of study the people residing in the work area Puskesmas Harapan Raya With a population about 13.750 and the number of samples from the190 people. Sampling techniques used is purposive sampling .The result showed that there is a connection between environmental sanitation:( p value 0,000, the por = 4,426 ), education: (p value 0,010, the por = 2,341 ), knowledge ( p value 0,002 , the por = 2,627 ), Solid waste management ( p value: 0,036, the por = 2,061 ) meaningful relationship with behavior in prevention of the disease with 3m plus It is hoped that the Harapan Raya Puskesmas will carry out counseling on abuse by implementing 3M Plus,Always urge people to maintain clean environment in not letting the thriftdeveloping the dengue
Digitalization in Processes
Authors: Vorlet Olivier , Neutsch Lukas , Kronseder Christian , Kuhn Alexandre 
Published: September 2021

Digitalization is having an increasing impact on all industrial sectors, including the chemical and biotechnological industries. Aiming for innovative research and development, the Swiss Universities of Applied Sciences play a pivotal role in transferring academic knowledge and know-how to industrial practice. We review selected examples of projects related to the digitalization of processes and bioprocesses at four different institutions across Switzerland. These developments cover the whole spectrum of digital technologies, including big data, connectivity, analytics and automation. They are conducted in close collaboration with industrial partners and aim to support the growth of this important industrial sector.