bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal Phosphides Embedded with In Situ‐Formed Metal Phosphate Impurities as Buffer Materials for High‐Performance Potassium‐Ion Batteries
Authors: Ji Shunping , Song Chunyan , Li Junfeng , Hui Kwan San , Deng Wenjun , Wang Shuo , Li Haifeng , Dinh Duc Anh , Fan Xi , Wu Shuxing , Zhang Jintao , Chen Fuming , Shao Zongping , Hui Kwun Nam 
Published: September 2021

AbstractAs anodes for metal‐ion batteries, metal phosphides usually suffer from severe capacity degradation because of their huge volume expansion and unstable solid electrolyte interphase (SEI), especially for potassium‐ion batteries (PIBs). To address these issues, this study proposes amorphous phosphates acting as buffer materials. Ten types of metal phosphide composites embedded with in situ‐formed amorphous phosphates are prepared by one‐step ball milling using red phosphorus (RP) and the corresponding metal oxides (MOs) as starting materials. A zinc phosphide composite is selected for further study as a PIB anode. Benefitting from the effective suppression of volume variation, a KF‐rich SEI is formed on the electrode surface in the KFSI‐based electrolyte. The zinc phosphide composite exhibits a high reversible specific capacity and outstanding long‐term cycling stability (476 mAh g−1 over 350 cycles at 0.1 A g−1 after going through a rate capability test and 177 mAh g−1 after 6000 cycles at 1.0 A g−1) and thus achieves the best cycling performance among all reported metal phosphide‐based anodes for PIBs. This study highlights a low‐cost and effective strategy to guide the development of metal phosphides as high‐performance anodes for PIBs.
Gene action and genetic parameters of characters related to rice grain quality
Authors: Facchinello Paulo Henrique Karling , Carvalho Ivan Ricardo , Streck Eduardo Anibele , Aguiar Gabriel Almeida , Goveia Janaína , Feijó Michele , Pereira Roberto Ramos , Fagundes Paulo Ricardo Reis , Maia Luciano Carlos da , Lautenchleger Francine , Júnior Ariano Martins de Magalhães 
Published: September 2021

AbstractInformation about gene action, heritability, heredity, and potential gain estimated by selecting these characters is scarce. This study aims to estimate genetic parameters related to physical attributes of rice (Oryza sativa L.) grain quality. The crosses “BR/IRGA 409″ × “BRS Bojuru” and their reciprocal were performed, obtaining F1 and F2 generations and backcrosses (BC1 and BC2). After obtaining seeds, the experiment was conducted following a completely randomized design with replications determined by the total number of plants of each generation. Total chalky area (CA), white core (WC), vitreous whiteness (VW), caryopsis length (CL), caryopsis width (CW), caryopsis length × width (CL/CW), percentage of whole grains (WHO), and broken grains (BG) were evaluated. The experiment analyzed means and variances and genetic parameters of generations based on a complete model and additive‐dominant model. The physical attributes are inherited quantitatively, and the main genetic effect is the additive. However, there is a great environmental influence on the characters studied. The BR/IRGA 409 × BRS Bojuru cross makes it possible to obtain a greater genetic gain in the selection of chalky grain characters (CA, WC, and VW) as they express a narrower heritability, whereas BRS Bojuru × BR/IRGA 409 makes it possible to obtain a greater genetic gain in the selection of CL, CW, CL/CW, WHO, and BG. Parent plants affect the type of gene action. A gene action of partial dominance, overdominance, and complete dominance occurred among the physical attributes of grain quality.
Asymmetric Stepwise Reductive Amination of Aryl N‐Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis
Authors: Yang Bing , Fu Hao , Yuan Jing , Wen Simiaomiao , Wang Chunqin , Liu Qixing , Zhou Haifeng 
Published: September 2021

AbstractAn asymmetric reductive amination of aryl N‐heteroaryl ketones with Benzyl Amines has been realized via one‐pot two‐step process, using p‐toluenesulfonic acid and chiral iridium complexes as catalysts, a mixture of formic acid/triethylamine as a reductant. Twenty‐three examples of chiral aryl N‐heteroaryl methylamines were obtained with good yields and up to 99% ee.
Can closed‐off management in communities alleviate the psychological anxiety and stress caused by the COVID‐19 pandemic?
Authors: Liu Yiwei , Zhou Deshui , Geng Ximei 
Published: September 2021

AbstractSince the outbreak of the novel coronavirus (COVID‐19) pandemic, the number of individuals infected with the COVID‐19 has been increasing worldwide, posed a substantial threat to mental health. Therefore, discovering the means for blocking the transmission path of COVID‐19 and improving mental health is of great significance. Based on a survey on the life of urban and rural residents in China (in 2020), the study applied the least squares method to analyse the effect of closed‐off management on the psychological anxiety and psychological stress caused by the COVID‐19 pandemic. Furthermore, the bootstrap decomposition method was used to test for the mediating effects of satisfaction with and confidence in pandemic prevention. The study found that closed‐off management in communities exerted a negative effect on psychological anxiety and stress caused by the COVID‐19 pandemic. Additionally, satisfaction with and confidence in pandemic prevention played a mediating role on the psychological anxiety and stress caused by the COVID‐19 pandemic. Therefore, closed‐off management in communities will not only prevent the spread of the COVID‐19, but also improve satisfaction with and confidence in pandemic prevention and control. Furthermore, it will alleviate the psychological anxiety and stress caused by the COVID‐19 pandemic.
CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid‐derived suppressor cells
Authors: Gu Haitao , Deng Wensheng , Zheng Zhong , Wu Ke , Sun Feng 
Published: September 2021

AbstractIntroductionThe development of pancreatic ductal adenocarcinoma (PDAC) is closely tied with the immune system. C‐C motif chemokine ligands (CCL) were proved to lead to immune recruitment and training. Thus, we reckoned CCL2 to be the kernel of immune suppression in PDAC tissues.MethodsWe compared normal pancreatic tissues with PDAC tissues according to The Cancer Genome Atlas (TCGA) and clinical samples. Flow cytometry was used to identify M‐MDSCs. We further demonstrated immune suppression of M‐MDSCs according to proliferation rates of CD8+ T cells/CD4+ T cells. Levels of reactive oxygen species (ROS) and Arginase were also tested by flow cytometry, enzyme‐linked immunosorbent assay, and western blot analysis. We also analyzed the specific mechanisms by cluster analysis after CCL2 stimulating M‐MDSCs.ResultsWe found that CCL2 highly increased in PDAC tissues. CCL2 is positively related to CD33 and CD14, markers of monocytic myeloid‐derived suppressor cells (M‐MDSCs). We have demonstrated that CCL2 recruited M‐MDSCs into PDAC tissues both in vitro and in vivo. M‐MDSCs recruitment is accompanied by sustained immune suppression. Furthermore, we have found that M‐MDSCs impeded T cell proliferation and produced high levels of ROS and Arginase, which can be enhanced by CCL2. Mechanistically, CCL2 stimulated M‐MDSCs led to a significant upregulation of genes, a large part of which accumulated in the mitogen‐activated protein kinase signaling pathway. Treatment of aloesin, MAPK signaling inhibitor, relieved the associated immunosuppressive phenotype induced by CCL2.ConclusionsOur study indicates that PDAC cells produced CCL2, which promoted localized M‐MDSC recruitment and immune suppression, thereby promoting tumor progression.
Visual adaptation and retinal characterization of the Garganey (Anas querquedula): Histological and scanning electron microscope observations
Authors: Bassuoni Naglaa F. , Abumandour Mohamed M. A. , El‐Mansi Ahmed , Hanafy Basma G. 
Published: September 2021

AbstractThe present study was designed to provide a complete morphological description of the eye of the migratory Garganey duck (Anas querquedula) and its visual adaptation with the different surrounding environmental conditions during its migration journeys using a stereomicroscope, scanning electron microscope (SEM), and light microscope. The current work depends on six adult Garganey ducks that were captured from the area near and on the shores of Edku city. The obtained results revealed that the eye of the migratory Garganey duck has the features of both diurnal and nocturnal birds. The histological examination reveals that the pigmented epithelium of the retina has long prolongations filled with melanin. The cone is the dominant photoreceptor, but simple rods are present. The inner nuclear and ganglion cell layers are thick. SEM examination shows that the arrangement of the collagen fibrils on the external surface was reticular in shape. The radial folds present as pledged structures on the pigmented epithelium covered with circular structures. The main lens body has flat with hexagonal outlines fibers. The edges and surfaces of these hexagonal fibers were studded with protrusions or elevations (balls) and depressions (sockets). The sockets and balls were either rounded or ellipsoid in shape. The balls were more on the edges and the sockets on the surface. In conclusion, our findings indicated a higher degree of functional adaptation between the morphological structure of the eye and the surrounding environmental conditions.
A Consequence of Dispersity on the Self‐Assembly of Amphiphilic Homopolymers Containing Main‐Chain Azobenzene
Authors: Hu An , Shi Xianheng , Li Lishan , Zhang Wei , Zhang Zhengbiao , Zhou Nianchen , Zhu Xiulin 
Published: September 2021

AbstractThe self‐assembly of amphiphilic oligomers/polymers is a versatile and promising approach for creating nonspherical polymeric nanoparticles. Discrete amphiphilic oligomers/polymers with molecularly defined structures are ideal candidates for fabricating smart nanoparticles and for achieving a deeper understanding of structure‐controlled self‐assembly. Herein, discrete and disperse amphiphilic homopolymers of PAZOnTEG2n, with hydrophobic azobenzene are designed and synthesized as the main chains tethered with hydrophilic tetraethylene glycol monomethyl ether (TEG) units, to accurately investigate the impact of dispersity on their self‐assembly in solution. The discrete‐PAZO8TEG16 in DMF/water and in THF/water results in the formation of 2D lamellae, while the dispersed counterpart prefers to self‐assemble into spherical micelles. The significant difference is due to their distinction between interior structures of assembly. Furthermore, photoisomerization of azobenzene triggers dissociation/reassembly for discrete polymeric nanoparticles but no obvious change for the dispersed counterparts under irradiation with UV/vis light. This work reveals the influence of dispersity on the self‐assembly of amphiphilic polymers and stimuli‐responsive properties of their nanomaterials, which is desirable for universal applicability in fabricating smart 2D lamellas.
Extensive surgery in medication‐related osteonecrosis of the jaw for the prevention of infective endocarditis
Authors: Narai Takashi , Tamura Takayuki , Fujii Nobuyuki , Harada Yusei , Watanabe Soh , Kodani Isamu 
Published: September 2021

AbstractInfective endocarditis (IE) is one of the most common diseases occurring in patients with valvular heart disease (VHD). One of the causes of IE is bacteremia caused by oral jaw infections, including medication‐related osteonecrosis of the jaw (MRONJ) and oral surgery. We performed an extensive surgery for MRONJ prior to aortic valve replacement with severe aortic stenosis (SAS) for IE prevention. In patients with SAS and MRONJ who are being suggested a surgery on standby for VHD, a prior extensive surgery for MRONJ should be considered to prevent the risk of IE.
Highly Facile, Regio‐ and Stereoselective Synthesis of Spiropyrrolidine‐5‐aza‐2‐oxindole Derivatives through Multicomponent 1,3‐Dipolar Cycloaddition Reaction and Their In‐Vitro and In‐Silico Biological Studies
Authors: Shinoj Kumar P. P. , Krishnaswamy G. , Desai Nivedita R. , Sreenivasa S. , Aruna Kumar D. B. 
Published: September 2021

AbstractHighly facile one pot synthesis of an assortment of novel spiropyrrolidine 5‐aza‐2‐oxindole derivatives via 1, 3‐di polar cycloaddition reaction has been reported. The underlying concept of Huisgen reaction was applied wherein the azomethine ylides (1,3‐dipoles), generated in‐situ from isatin‐derived compounds and cyclic / acyclic α‐amino acids through the thermal decarboxylation, reacted with exo‐cyclic benzylidine derivatives (dipolarophiles) of 5‐aza‐2‐oxindole afforded plethora of spiropyrrolidine 5‐aza‐2‐oxindoles in excellent yield. High regio‐ and stereo selectivity were accomplished employing this methodology and optimum yield was obtained when reaction carried out under methanol reflux in presence of triethylamine. Furthermore, the compounds were tested for their in‐vitro biological potency as anti‐microbial and anti‐mycobacterial. Antibacterial screening result reveals that out of fifteen compounds four compounds emerged with moderate to reasonable activity against gram negative E. coli and P. aeruginosa. Antifungal screening resulted in identification of two compounds as moderate antifungal agents against A. niger. Antimycobacterial activity results revealed that the four compounds displayed good to moderate in‐vitro activity with MIC=12.5 μg/mL against H37Rv strain as compared to standard pyrazinamide (MIC=3.12 μg/mL). Additionally, molecular docking study was carried out to understand the possible binding modes of the synthesized derivatives within the active site of antibacterial (PDB ID : 3ACX), antifungal (PDB ID : 1IYL) and antimycobacterial (PDB ID : 4TZT) target proteins and were found to display good docking energies. Besides, ADMET properties of the synthesized compounds have shown drug likeness with good oral absorption and moderate BBB permeability.
Marangoni Flow Manipulated Concentric Assembly of Cellulose Nanocrystals
Authors: Shao Rongrong , Meng Xiao , Shi Zhaojie , Zhong Jiajia , Cai Zheren , Hu Junhao , Wang Xiao , Chen Gang , Gao Shenghua , Song Yanlin , Ye Chunhong 
Published: September 2021

AbstractTunable assembly of cellulose nanocrystals (CNCs) is important for a variety of emerging applications in optics, sensing, and security. Most exploited assembly and optical property of CNCs are cholesteric assembly and corresponding circular dichroism. However, it still remains challenge to obtain homogenous and high‐resolution cholesteric assembly. Distinct assembly and optical property of CNCs are highly demanded for advanced photonic materials with novel functions. Herein, a facile and programmable approach for assembling CNCs into a novel concentric alignment using capillary flow and Marangoni effect, which is in strike contrast to conventional cholesteric assembly, is demonstrated. The concentric assembly, as quantitatively evidenced by polarized synchrotron radiation Fourier transform infrared imaging, demonstrates Maltese cross optical pattern with good uniformity and high resolution. Furthermore, this Maltese cross can be readily regulated to “on/off” states by temperature. By combining with 3D inkjet technology, a functional binary system composed of “on”/“off” CNCs optical patterns with high spatial resolution, fast printing speed, good repeatability, and precisely controllable optical property is established for information encryption and decryption. This concentric assembly of CNCs and corresponding tunable optical property emerge as a promising candidate for information security, anticounterfeiting technology, and advanced optics.
Reproductive outcome after early miscarriage: comparing vaginal misoprostol treatment with expectant management in a planned secondary analysis of a randomized controlled trial
Authors: Fernlund A. , Jokubkiene L. , Sladkevicius P. , Valentin L. 
Published: September 2021

ABSTRACTObjectiveTo compare the reproductive outcome after early miscarriage between women managed expectantly and those treated with vaginal misoprostol.MethodsThis study was a planned secondary analysis of data collected prospectively in a randomized controlled trial comparing expectant management with vaginal misoprostol treatment (single dose of 800 µg) in women with early embryonic or anembryonic miscarriage and vaginal bleeding. The outcome measures were the number of women with a clinical pregnancy conceived within 14 months after complete miscarriage and the outcome of these pregnancies in terms of live birth, miscarriage, ectopic pregnancy and legal termination of pregnancy. The participants replied to a questionnaire sent by post covering their reproductive history ≤ 14 months after the index miscarriage was complete. Supplementary information and data for women who did not return their questionnaire were retrieved from medical records.ResultsOf 94 women randomized to misoprostol treatment and 95 allocated to expectant management, 94 and 90 women, respectively, were included for analysis. Information on reproductive outcome was available for 89/94 (95%) and 83/90 (92%) women, respectively. Complete miscarriage without surgical evacuation was achieved within 31 days in 85% (76/89) of the women in the misoprostol group and in 65% (54/83) of those managed expectantly. The proportion of women treated with surgical evacuation was 33% (27/83) in the expectant‐management group vs 12% (11/89) in the misoprostol group. At 14 months after the index miscarriage was complete, 75% (67/89) of women treated with misoprostol and 75% (62/83) of those managed expectantly had achieved at least one clinical pregnancy, while 40% (36/89) and 35% (29/83), respectively, had had at least one live birth (mean difference, 5.5% (95% CI, −9.7 to 20.3%)). When considering the outcome of all pregnancies conceived within 14 months after the index miscarriage was complete, 63% (56/89) of women in the misoprostol group and 55% (46/83) of those in the expectant‐management group delivered a live baby after a pregnancy (mean difference, 7.5% (95% CI, −7.9 to 22.4%)).ConclusionWomen with early miscarriage can be reassured that fertility is similar after misoprostol treatment and expectant management. © 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Exploring Regenerative Co-benefits of Biophilic Design for People and the Environment
Authors: Andreucci Maria Beatrice , Loder Angela , McGee Beth , Brajković Jelena , Brown Martin 
Published: September 2021

AbstractThere is an increasing awareness of the role that buildings, districts, and neighborhoods play on health in the wake of the Covid-19 pandemic that coincides with pressing climate concerns. This has renewed attention to the benefits of nature for both human and climate health. Buildings, cities, and regions are attempting to align regenerative design principles with human health goals but often lack the tools and knowledge to do so. This is partly rooted in a failure to understand how to apply research and policy for different contexts as well as at different scales. It is also still uncertain exactly what types of nature can lead to which types of benefit, and for whom, despite long-standing research within the environmental psychology, sustainability, and design fields. This chapter outlines key research paradigms that influence the way we understand the benefits of nature, where biophilic design theory sits in this field, and how it can be and has been applied at different scales through two case studies at the building and city scale. This chapter ends with the proposal of new directions for integrating biophilic design into regenerative design and policy.
Domain Analysis with TRIZ to Define an Effective “Design for Excellence” Framework
Authors: Brad Stelian 
Published: September 2021

AbstractDesign for Excellence (DfEx) is the name given to an engineering process where a product is designed to meet a set of objective functions that cover its lifecycle. There are negative correlations between different objective functions in this set and issues related to technological complexity are added, since modern products typically fall into the category of smart connected mechatronic products. This context leads to complexity in terms of tackling the design process. Simultaneous engineering and PLM platforms can only partially handle such levels of complexity. To our knowledge, the subject of DfEx was treated in current researches from a limited perspective, which does not necessarily cover the complexity of the present-day context. In order to formulate a reliable DfEx framework, this research considers a strategy based on tools that manage in a systematic way the process of identifying the comprehensive set of barriers and conflicts that obstruct DfEx. This research highlights the level of complexity in setting up a reliable methodology to DfEx of modern, sophisticated mechatronic products. A set of guidelines to be placed at the foundation of an effective DfEx methodology is formulated with the support of TRIZ.
Impact of the menstrual cycle on commercial prognostic gene signatures in oestrogen receptor-positive primary breast cancer
Authors: Haynes Ben P. , Schuster Gene , Buus Richard , Alataki Anastasia , Ginsburg Ophira , Quang Le Hong , Han Pham Thi , Khoa Pham Hong , Van Dinh Nguyen , Van To Ta , Clemons Mark , Holcombe Chris , Osborne Caroline , Evans Abigail , Skene Anthony , Sibbering Mark , Rogers Clare , Laws Siobhan , Noor Lubna , Cheang Maggie Chon U. , Cleator Susan J. , Smith Ian E. , Dowsett Mitch 
Published: September 2021

Abstract
Purpose
Changes occur in the expression of oestrogen-regulated and proliferation-associated genes in oestrogen receptor (ER)-positive breast tumours during the menstrual cycle. We investigated if Oncotype® DX recurrence score (RS), Prosigna® (ROR) and EndoPredict® (EP/EPclin) prognostic tests, which include some of these genes, vary according to the time in the menstrual cycle when they are measured.

Methods
Pairs of test scores were derived from 30 ER-positive/human epidermal growth factor receptor-2-negative tumours sampled at two different points of the menstrual cycle. Menstrual cycle windows were prospectively defined as either W1 (days 1–6 and 27–35; low oestrogen and low progesterone) or W2 (days 7–26; high oestrogen and high or low progesterone).

Results
The invasion module score of RS was lower (− 10.9%; p = 0.098), whereas the ER (+ 16.6%; p = 0.046) and proliferation (+ 7.3%; p = 0.13) module scores were higher in W2. PGR expression was significantly increased in W2 (+ 81.4%; p = 0.0029). Despite this, mean scores were not significantly different between W1 and W2 for any of the tests and the two measurements showed high correlation (r = 0.72–0.93). However, variability between the two measurements led to tumours being assigned to different risk categories in the following proportion of cases: RS 22.7%, ROR 27.3%, EP 13.6% and EPclin 13.6%.

Conclusion
There are significant changes during the menstrual cycle in the expression of some of the genes and gene module scores comprising the RS, ROR and EP/EPclin scores. These did not affect any of the prognostic scores in a systematic fashion, but there was substantial variability in paired measurements.