bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Stability of Periodic Motions of a Two-Body SystemWith Flexible Connection in an Elliptical Orbit
Authors: Zhong Xue , Zhao Jie , Yu Kaiping , Xu Minqiang 
Published: March 2021

Abstract
This paper deals with periodic motions and their stability of a flexible connected two-body system with respect to its center of mass in a central Newtonian gravitational field on an elliptical orbit. Equations of motion are derived in a Hamiltonian form and two periodic solutions as well as the necessary conditions for their existence are acquired. By analyzing linearized equations of perturbed motions, Lyapunov instability domains and domains of stability in the first approximation are obtained. In addition, the third and fourth order resonances are investigated in linear stability domains. A constructive algorithm based on a symplectic map is used to calculate the coeffcients of the normalized Hamiltonian. Then a nonlinear stability analysis for two periodic solutions is performed in the third and fourth order resonance cases as well as in the nonresonance case.
On the dielectric constant of titanium dioxide
Authors: Bonkerud Julie , Zimmermann Christian , Weiser Philip Michael , Vines Lasse , Monakhov Eduard V. 
Published: March 2021

Abstract
Conductive rutile TiO2 has received considerable attention recently due to a number of applications. However, the static dielectric constant in conductive, reduced or doped TiO2 appears to cause controversy with reported values in the range 100-10000. In this work, we propose a method for measurements of the dielectric constant in conductive, n-type TiO2 that involves: (i) hydrogen implantation to form a donor profile at a known depth, and (ii) capacitance-voltage measurements for donor profiling. We can not confirm the claims stating an extremely high dielectric constant. On the contrary, the dielectric constant of conductive, reduced rutile TiO2 is similar to that of insulating rutile TiO2 established previously, with a Curie-Weiss type temperature dependence and the values in the range 160-240 along the c-axis.
Performance, Combustion and Emission evaluation of Direct Injection diesel engine fueled with ZnO dispersed waste cooking oil biodiesel
Authors: M Dhanarasu , A Rameshkumar K , P Maadeswaran 
Published: March 2021

Abstract
In present scenario, the fast depletion of fossil fuels and energy crises motivated the researchers towards finding an alternative sources for energy. In this work, the performance, combustion and emission of hydrothermally synthesized ZnO nanoparticles dispersed waste cooking oil biodiesel in single cylinder, four stroke, Direct Injection- Diesel Engine with eddy current dynamometer was investigated. The synthesized ZnO nano particles were characterized by XRD, FTIR, SEM and EDX to find crystallinity, functional groups and surface morphology. Waste cooking oil biodiesel was produced via conventional one step alkali catalyst Trans-esterification process. Test fuels were prepared with dispersion of ZnO nanoparticles in the concentration of 10ppm, 20ppm and 30ppm with B20 (20% waste cooking oil biodiesel and 80% diesel) with the aid of magnetic stirrer and ultra-sonication. The test results exposed that the addition of ZnO nanoparticles with B20 gave better Performance in terms of BTE and BSFC compared to B20. The addition of ZnO nano particles with 30ppm concentration was identified as better fuel among all tested fuels in this work. 30ppm addition of ZnO nano particles with B20 records 1.78 % increase in BTE and 10.34% decrease in BSFC. The emission like CO, HC and smoke were 20%, 15.4% and 17.39% lower than diesel. On the other hand NOx was slightly higher than diesel but lower than B20.
Camrelizumab-related lethal arrhythmias and myasthenic crisis in a patient with metastatic thymoma: a case report
Authors: Zhang Bo , Gyawali Laxman , Liu Zengzhang , Du Huaan , Yin Yuehui 
Published: March 2021

Abstract
Immune checkpoint inhibitors (ICIs) have emerged in recent years as a promising treatment option for several malignant tumors. However, ICI therapy has also been associated with various immune-related adverse events (irAEs), especially with pre-existing autoimmune status, which sometimes can be life-threatening. A 68-year-old woman diagnosed with metastatic thymoma was treated with camrelizumab as her initial anti-tumor protocol at a nearby hospital. On 11 days after the first dose of camrelizumab, the patient was admitted to our hospital with symptoms of dyspnea, fatigue, and poor appetite. Workup on admission indicated dramatically elevated transaminase, troponin I, creatine kinase, and creatine kinase MB and a new-onset conduction abnormality on electrocardiography. She had no other underlying disease prior to ICI treatment; therefore, ICI-related myocarditis, myositis and hepatitis were diagnosed, and intravenous methylprednisolone (80mg/day) and other supporting treatments were administered sequentially. Coronary angiography was performed on day 3 of hospitalization, but no abnormality was detected. On the same day, she lapsed into a coma with respiratory muscle failure, which was highly suspected of myasthenic crisis. Therefore, mechanical ventilation and higher dose of methylprednisolone (1 g/day) plus intravenous immunoglobulin (20g/day) were applied immediately. The third artrioventricular block occurred abruptly and an urgent temporary pacemaker was placed. Repeated ventricular tachycardia (VT) occurred, and even multiple antiarrhythmic drugs used in combination failed to alleviate the VT storm. On day 5 of hospitalization, she suffered from ventricular fibrillation and die of cardiac arrest. In conclusion, close follow-up should be conducted after ICI treatment, especially for patients already with or at high risk for autoimmune disorders. Once diagnosed with severe irAEs, prompt high dose of glucocorticoid alone or in combination with other immunomodulators if necessary should be administered. A multidisciplinary team approach is of importance for better management of patients with multiple organs involvement.
Effects of Pomegranate Juice (Punica Granatum) on Inflammatory Biomarkers and Complete Blood Count in Patients with COVID-19: A Structured Summary of a Study Protocol for a Randomized Clinical&nbsp;Trial
Authors: Yousefi Mojtaba , Sadriirani Mohammadreza , Pourmahmoodi Azizollah , Mahmoodi Sara , Samimi Bahar , Hosseinikia Mahboobe , Saeedinezhad Zaker , Panahande SeyedBahman 
Published: March 2021

Abstract
ObjectivesThis study is conducted to investigate efficacy of pomegranate juice on inflammatory biomarkers, C-reactive protein (CRP), interleukin 6(IL-6), erythrocyte sedimentation rate (ESR) and complete blood count (CBC) in hospitalized patients with mild to moderate coronavirus disease 2019 (COVID- 19).Trial DesignThis is a randomized, placebo-controlled, double-blind, parallel 2-arm (1:1 ratio) clinical trial.
Role of the apparent diffusion coefficient as a predictive factor for tumor recurrence in patients with intracranial epidermoid tumor
Authors: Oh Hyeong-Cheol , Hong Chang-Ki , Yoo Jihwan , Lee Kyu-Sung , Cha Yoon-Jin , Ahn Sung-Jun , Suh Sang-Hyun , Park Hun Ho 
Published: March 2021

Abstract
Purpose.

Intracranial epidermoid tumors are slowly growing benign tumors, but due to adjacent critical neurovascular structures, surgical resection is challenging, with the risk of recurrence. The apparent diffusion coefficient (ADC) has been used to evaluate the characteristics of brain tumors, but its utility for intracranial epidermoid tumors has not been specifically explored. This study analyzed the utility of preoperative ADC values in predicting tumor recurrence for patients with intracranial epidermoid tumors.
Methods.

Between 2008 and 2019, 23 patients underwent surgery for intracranial epidermoid tumor, and their preoperative ADC data were analyzed. The patients were divided into two groups: the recurrence group, defined by regrowth of the remnant tumor or newly developed mass after gross total resection on magnetic resonance imaging (MRI); and the stable group, defined by the absence of growth or evidence of tumor on MRI. Receiver operating characteristic (ROC) analysis was used to obtain the ADC cutoff values for predicting tumor recurrence. The prognostic value of the ADC was assessed using Kaplan-Meier curves.
Results.

The minimum ADC values were significantly lower in the recurrence group than in the stable tumor group (P = 0.046). ROC analysis showed that a minimum ADC value lower than 804.5×10− 6 mm2/s could be used to predict higher recurrence risk of intracranial epidermoid tumors. Subtotal resection, younger age, and mean and minimum ADC values lower than the respective cutoffs were negative predictors of recurrence-free survival.
Conclusions.

Minimum ADC values could be useful in predicting the recurrence of intracranial epidermoid tumors.
Diversity, Utilization and Dependency on NTFPs – A case study of a National Park in Indian sub-Himalayan Region
Authors: Lepcha Lakpa Doma , Shukla Gopal , Vineeta  , Chakravarty Sumit 
Published: March 2021

Abstract
Background: Non timber forest products (NTFPs) greatly contribute to livelihood, development, and poverty alleviation of indigenous and rural communities across the tropics. We also assumed that the fringe communities inhabiting Jaldapara National Park (JNP) of Indian eastern sub-Himalayan region largely rely on the NTFPs for their livelihood due to its remote and isolated location with no physical infrastructure and facilities. Methodology: Multistage sampling technique was used for the study. The sample size was 205 households selected randomly from a sample frame of 10 villages. Descriptive statistics was employed to analyze and summarize the data. Results: A total of 146 NTFP species was documented. The communities in our study area also relied on their NTFP collection/harvest for food, medicine, firewood, animal fodder, and other socio-cultural items for household use and cash income. Income from NTFPs contributed on an average 45 % of the total annual household income of the sampled households.Conclusion: NTFPs provided a natural insurance to households especially during the periods of scarcity. Focused interventions with technical and financial support are recommended to uplift the livelihood of the forest fringe indigenous communities in JNP.
The Assessment of Structural and Functional Test Results for Early Detection of Hydroxychloroquine Macular Toxicity
Authors: Sonalcan Vildan , Koklu Burcin , Aksoy Nilgün , Gündoğdu Kübra , Çelik Erkan , Alagöz Gürsoy 
Published: March 2021

Abstract
PurposeTo assess structural (optical coherence tomography, fundus autofluorescence) and functional (contrast sensitivity and visual field) test results used for detecting early retinal changes in patients who were using oral hydroxychloroquine.METHODSPatients who were taking oral hydroxychloroquine for at least one year were divided into two groups in accordance with the duration of drug use. Group 1 and 2 comprised patients with drug use exceeding 5 years and 1–5 years, respectively. Besides, drug-free control group was composed. Upon full ophthalmic examination, the mean retinal nerve layer thickness (RNFL), central macular thickness (CMT), ganglion cell-inner plexiform layer thickness (GC-IPL), static 10 − 2 visual field, fundus autofluorescence (FAF) imaging, and contrast sensitivity tests were performed and statistically compared between groups.RESULTSRNFL thickness was found to be statistically significantly lower in the median and temporal quadrant than in the control group. No significant difference was found between the groups in the other quadrants. The GC-IPL sectoral and mean thickness were found to be statistically lower in all quadrants as compared to the control group in the patient groups. CMT was also found to be similar in all three groups. There was no significant difference between the groups in visual field parameters. While macular FAF images were significantly higher in the drug users than in the control group, no significant difference was found between the three groups in foveal FAF images. Contrast sensitivity measurements were significantly lower in the patient groups than in the control group at all spatial frequencies except 6 and 18 cycles / degree.CONCLUSIONSThe combined use of structural and functional tests in patients using hydroxychloroquine provides useful information in detecting early retinal changes.
Identification of Lipid Metabolism-Related Genes as Prognostic Indicators in Papillary Thyroid Cancer
Authors: Wen Shi-Shuai , Luo Yi , Wu Wei-Li , Zhang Ting , Yang Yi-Chen , Ji Qing-Hai , Wu Yi-Jun , Shi Rong-Liang , Ma Ben , Xu Midie , Qu Ning 
Published: March 2021

Abstract
Purpose
Lipid metabolism plays important roles not only in the structural basis and energy supply of healthy cells but also in the oncogenesis and progression of cancer. In this study, we investigate the prognostic value of lipid metabolism related genes in papillary thyroid cancer (PTC).
Methods
The in time to recurrence predictive gene signature was developed, internally and externally validated based on PTC datasets including The Cancer Genome Atlas (TCGA) and GSE33630 datasets. Univariate, LASSO and multivariate Cox regression analysis were applied to assess prognostic genes and build the prognostic gene signature. The expression profiles of prognostic genes were further determined by immunohistochemistry by using in-house cohorts which enrolled 97 patients. Kaplan-Meier curve, time-dependent receiver operating characteristic curve, nomogram and decision curve analysis were used to assess the performance of the gene signature.
Results
We identified four recurrence-related genes, PDZK1IP1, TMC3, LRP2 and KCNJ13, and established a 4-gene signature recurrence risk model. The expression profile of the 4 genes in the TCGA and in-house cohort indicated that stage T1/T2 PTC and locally advanced PTC exhibited notable associations not only with clinicopathological parameters but also with recurrence. Calibration analysis plots indicated the excellent predictive performance of the prognostic nomogram constructed based on the gene signature. GSEA showed that high-risk cases exhibited changes in several important tumorigenesis-related pathways, such as the intestinal immune network and the p53 and Hedgehog signalling pathways.
Conclusion
Our findings indicate that lipid metabolism-related gene profiling represents a potential marker for prognosis and treatment decisions for PTC patients.
Surface Texturing of Fan-blade Body by Random-orbital Polishing With in-line Aqueous Mist
Authors: Danaraj Edgar Jeevan , Yeo Swee Hock 
Published: March 2021

Abstract
Airfoil structures such as fan blades have free form geometry which require a high level of precision in order to create a uniform finish for ideal gas path flow. Challenges in machining of such parts have led to rework in order to remove defects and conform to dimensional requirements at the same time. Mechanical polishing is the most common method to remove surface irregularities on fan blades such as scallop height, while maintaining the required dimensions. After the polishing process, the part will undergo shot peening, vibratory finishing and later, painting and coating at the final stages. It is therefore essential for the fan blade surface to pre-treated with rough, uniform textures in order to promote good surface-to-surface adhesion at the end of the manufacturing cycle. Generally, the polishing process is assisted by an external cooling medium applied on the part surface at intervals. This method of removing heat is not effective, as the polished surface may experience scratches or distortion, especially around thin-walled sections of the leading edge in fan blade. The existing polishing method uses a single-axis rotary tool can produce average surface roughness, Ra, of 1.2 µm that satisfies the requirement. However, this form of aggressive polishing has a high material removal rate, resulting in excessive reduction in material thickness which leads to the rejection of costly fan blade.This study a new localized polishing method and examines its effect on the surface topography of an airfoil component made of aluminum alloy. The area of interest is focused on the leading edge of a fan blade at which polishing is carried out using a random-orbital polishing tool with modified features to incorporate internal cooling capability. Experimental trials are conducted to study the effects of surface finish with fixed grain abrasive disks under four conditions. A cold gun is connected in-line to guide cold air inside the internal passages of the tool and out onto the surface of the part directly. A secondary cooling source by water nozzle spray is integrated in the tool to mix with the cold air jet and form an aerosol mist during tool activation. Surface topography of the samples are determined by arithmetic mean deviation, maximum height and root mean square of the profile. Surface roughness was performed using an optical profilometer. The localized polishing method achieved a desirable surface roughness, Ra of 0.8 µm, while removing all traces of scallop height and maintaining the leading-edge thickness within tolerance. The study showed that the new method produced a topography that is uniformly textured. This method can improve the manufacturing cycle time.
Cytomegalovirus antigen-specific T Cell immune response in patients with autoimmune diseases under different cytomegalovirus infection status
Authors: Ma Huimin , Tan Yuting , Liu Xiaoqing , Shi Xiaochun , Zheng Wenjie , Cui Jingtao , Zhang Lifan , Dou Yaling , Zhou Baotong 
Published: March 2021

Abstract
Background: T-cell immunity is important for the control of cytomegalovirus (CMV) infection. The frequency of IFN-γ secreting T cells after stimulation with CMV-specific protein-1 (IE-1) and phosphoprotein 65 (pp65) antigen can help predict the risk of active CMV infection. Patients with autoimmune diseases have a high incidence of active CMV infection, but the CMV antigen-specific T cell immune response of this population is still blank in the world. This study aimed to use T-SPOT.CMV to investigate CMV antigen-specific T cell immune response in patients with autoimmune diseases under different CMV infection conditions.Methods: Patients with autoimmune diseases in the Peking Union Medical College Hospital from March, 2017 to October, 2020 were continuously selected. According to the definition, the subjects were divided into latent CMV infection group and active CMV infection group. T-SPOT.CMV was used to evaluate CMV antigen-specific T cell immune response under different CMV infection status, and the possible influential factors of CMV antigen-specific T cell immune response were further analyzed.Results: Fifty patients with latent CMV infection and fifty patients with active CMV infection were enrolled. After stimulated by immediate early IE-1 and pp65 antigen, the median frequency of IFN-γ secreting T cells in active CMV infection group were all significantly lower than that in latent CMV infection group (p<0.001), and in CMV disease group was significantly lower than that in latent CMV infection group (p<0.001). After stimulated by pp65, the median frequency of IFN-γ secreting T cells with CD4+ T cell counts < 200/ul was significantly lower than that of CD4+ T cell counts ≥ 200/ul (p=0.043), and those with CD8+ T cell counts < 250/ul was significantly lower than that of CD8+ T cell counts ≥ 250/ul (p=0.03). The frequency of IFN-γ secreting T cells stimulated by pp65 was significantly higher than IE-1.Conclusions: In patients with autoimmune diseases, the CMV antigen-specific T-cell immune response in patients with active CMV infection was significantly lower than that with latent CMV infection. IE-1 was considered as a more stable antigen with better effect than pp65. Lymphocyte, CD4+T cell and CD8+T cell count might affect CMV antigen-specific T cell immune response.
Effectiveness of Jogging, Eye Movement Exercises, and Diaphragmatic Breathing in Reducing Migraine Symptoms: A Randomized Controlled Trial
Authors: Rahimi Mohammad Dawood , Alidoosti Fatemeh , Hassani Pouriya , Ghasemi Mohammad Mahdi , Fadardi Javad Salehi 
Published: March 2021

Abstract
Background: electrophysiological dysresponsiveness (ED) is apparent in a migraine brain. Various methods have been suggested to regulate ED, including electrochemical transduction or regulation of Nitric Oxide (NO) and Brain-Derived Neurotrophic Factor (BDNF), jogging, eye movement exercises, and diaphragmatic breathing.Objectives and methods: A three-group, double-blind, and randomized design with pre-test, post-test, and follow-up assessment was used to test the effectiveness of jogging, eye movement exercises, and diaphragmatic breathing in the treatment of patients with episodic migraine. International Classification of Headache Disorders 3rd edition (ICHD-3) was used to diagnose the migraine patients, who were randomly assigned to one of the three study groups to perform either 12 consecutive weeks of (a) jogging and eye movement exercises (n = 22) ;(b) jogging and diaphragmatic breathing (n = 19); or (c) treatment as usual (TAU), receiving prescribed medication (n = 22) group.Results: The results of a series of MANCOVA showed that, compared to the TAU group, patients in the two experimental groups showed significant reductions in the frequency, duration, and intensity of their episodic migraine attacks. Moreover, the frequency of menstrual cycle-dependent headache attacks and over the counter drugs use were reduced, and the quality of sleep and drinking water were improved at post-test and a 12-month follow-up.Conclusion: The results suggest that jogging and eye movement exercises or jogging and diaphragmatic breathing can be used as effective alternative interventions in the treatment of episodic migraine.Trial registration retrospectively: Ir.mums.fm.rec.1396.362
Therapeutic Efficacy of Urtica dioica and Evening Primrose in Patients with Rheumatoid Arthritis: A Randomized Double-Blind, Placebo-Controlled Clinical Trial
Authors: Abd-Nikfarjam Bahareh , Abbasi Mahnaz , Memarzadeh Mohammadreza , Farzam Seyed-Amir , Jamshidian Azam , Dolati-Somarin Amirhossein 
Published: March 2021

Abstract
Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease. The pharmacological therapy of RA is often symptomatic to mitigate pain and inability with analgesics and drugs with defined side effects and risks. Complementary medicines might decrease the signs of RA and reduce the need for these medicines. In the present study, we investigated the anti-rheumatic, anti-inflammatory and anti-oxidant effects of Urtica dioica and Evening Primrose Ogil (EPO), in patients with RA. Methods: This randomized, double‐blind, controlled trial involved 90 RA patients, and randomly assigned them into EPO, Urtica dioica, and placebo groups. The potential effect of these herbal medicines on Disease Activity Score (DAS) 28, Visual Analogue Scale (VAS), Total Anti-oxidant Capacity (TAC), IL-17, Rheumatoid Factor (RF), anti-cyclic citrullinated peptide antibodies (Anti-CCP), C Reactive Protein (CRP), and Erythrocyte Sedimentation Rate (ESR) before and after clinical trial were evaluated. The trial registration number is IRCT20201001048897N1.Results: After a three month follow up, the mean values of DAS28, IL-17, TAC, RF, and CRP in EPO and Urtica dioica groups were significantly different from the placebo group. However, the VAS, Anti-CCP, and ESR at baseline and at the end of the study were not significantly different between the three groups. After the intervention, the within-group DAS28 in the EPO and Urtica dioica groups, and placebo group reduced significantly compared to the baseline.Conclusion: Medicinal plants EPO and Urtica dioica were appeared to decrease inflammatory factors, and can improve the symptoms of RA. Thus, EPO and Urtica dioica have great potential as a complementary therapy in RA patients.