bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive propositions and semantic expressions
Authors: Davis Wayne A. 
Published: June 2021

Abstract
Building on their well-known act theory of propositions, Soames and Hanks have proposed a theory of what it is for sentences to express propositions, thereby answering a central question about the foundations of semantics. The basic idea is that for a sentence to express a proposition in a language is for speakers of the language to use the sentence to perform the act that is the proposition. I argue that this general account of expression fails to explain how incorrect usage is possible, how what sentences express differs from what they implicate, how unused sentences can express propositions, how compositional meanings are possible, and how to specify who the speakers of L are without circularity. I go on to show how these things can be explained within the structured cognitive proposition framework.
A contextualist treatment of negative existentials
Authors: Voltolini Alberto 
Published: June 2021

Abstract
In this paper, I want to vindicate the contextualist treatment that is typically applied by artefactualists on fictional entities (ficta) both to general and to singular negative existentials. According to this treatment, the truth value of a negative existential, whether general or singular, changes according to whether the existential quantifier or the first-order existence predicate is contextually used as respectively ranging over and applying to a restricted or an unrestricted domain of beings. In (2003), Walton has criticized this treatment with respect to singular negative existentials in particular. First of all, however, as (Predelli, Stefano. 2002. ‘Holmes’ and Holmes. A Millian analysis of names from fiction. Dialectica 56. 261–279) has shown, this treatment can be applied to singular predications in general, independently of the existential case. Moreover, not only does applying it to singular negative existentials explain why we may contextually use the quantifier restrictedly in general negative existentials, but also it accounts for why comparative negative existentials, both singular and general, may have different truth values as well depending on the comparison group they mobilize.
The distinction between semantics and pragmatics: The point of view of semiotics
Authors: Paolucci Claudio 
Published: June 2021

Abstract
In this paper I will try to outline the reasons why, in order to understand the life and the nature of meaning, the semiotic tradition has always thought that it was better not to separate semantics and pragmatics. I will first reconstruct the history of this idea, grounded in Pragmatism and in Structural Linguistics. Later, I will deal with its first formulation in A Theory of Semiotics by Umberto Eco. In the second part of the paper, I will work on the idea by Ferdinand de Saussure that meanings are values, that is, indeterminate entities whose identity is determined only through reciprocal determination. I will claim that this idea is the importation in linguistics of Leibniz’s principles of the differential calculus. In the final part of the paper, I will apply this idea to the distinction between semantics and pragmatics, claiming that meanings are better understood through a theory of modes of existence. If we understand the differential nature of meaning, we can see that meanings live only through the using of the expressions and these variations contribute to offer stability within the transformations, without creating a stable object defined by its properties and endowed with an independent existence split from the relationships that define it.
Numeral terms and the predictive potential of Bayesian updating
Authors: Skoczeń Izabela , Smywiński-Pohl Aleksander 
Published: June 2021

AbstractIn the experiment described in the paper Noah Goodman & Andreas Stuhlmüller. 2013. Knowledge and im-plicature: Modeling language understanding as social cognition.Topics in Cognitive Science5(1). 173–184, empirical support was provided for the predictive power of the Rational Speech Act (RSA) model concerning the interpretation of utterances employing numerals in uncertainty contexts. The RSA predicts a Bayesian interdependence between beliefs about the probability distribution of the occurrence of an event prior to receiving information and the updated probability distribution after receiving information. In this paper we analyze whether the RSA is a descriptive or a normative model. We present the results of two analogous experiments carried out in Polish. The first experiment does not replicate the original empirical results. We find that this is due to different answers on the prior probability distribution. However, the model predicts the different results on the basis of different collected priors: Bayesian updating predicts human reasoning. By contrast, the second experiment, where the answers on the prior probability distribution are as predicted, is a replication of the original results. In light of these results we conclude that the RSA is a robust, descriptive model, however, the experimental assumptions pertaining to the experimental setting adopted by Goodman and Stuhlmüller are normative.
Analysis of a kinematic real-time robotic total station network for robot control
Authors: Lerke Otto , Schwieger Volker 
Published: June 2021

Abstract
The use of robots is widespread in the field of construction nowadays. Robots may be mobile or static depending on the specific task or application. One of the major challenges when implementing mobile robots is localisation. In the field of robotics, localisation is often performed in a relative sense, however some applications require absolute localisation. In order to provide absolute positions, appropriate sensors such as Global Navigation Satellite Systems (GNSS) or total stations can be employed. The underlying task is embedded within the Germany´s Excellence Strategy “Integrative Computational Design and Construction for Architecture (IntCDC)” funded by the German Research Foundation (DFG). The specific sub-project deals with issues of robot-robot collaboration and specifically aims the provision of absolute position and orientation, designated as pose, of a mobile construction robot. The determined pose information supports different control loops of the robot including automated driving, steering and tool operations. The choice of the sensor system favoured a robotic total station (RTS), because of its real-time capability and measurement accuracy. The measurement system is coupled with an Inertial Measurement Unit (IMU) for orientation. To counteract line-of-sight interference between the RTS and the target, the contribution proposes the use of a network of four spatially evenly distributed RTSs. The quality characteristics of different pose determination procedures of a mobile construction robot are investigated using methods from the geodetic network theory. Conclusions about accuracy and reliability distribution across the construction site are presented numerically and graphically.
Does Prenestinian fe⋮faked actually exist?
Authors: Mancini Marco 
Published: June 2021

Abstract
After more than a century since its discovery, the mystery of the Fibula Praenestina has been definitively solved. The artifact and the inscription are both authentic beyond any reasonable doubt. Complex spectrographic analyses published a few years ago have confirmed that the Fibula is not a forgery. However, quite paradoxically, an Early Latin reduplicated perfect fefaked is still implausible from a morphological point of view. This form continues to disturb the Early Latin linguistic framework, which can be reconstructed thanks to the available data at our disposal. The article presents a new reading of the text, which on the one hand confirms the congruity of the preterite morphology (not a reduplicated form of the root *d

h

ē- / d

h

ǝ-, but an ancient aorist similar to Faliscan făced / făcet) and on the other gives an account of the abnormal use of punctuation between <whe> and <wha>.
Retrospective evaluation of patients with X-linked adrenoleukodystrophy with a wide range of clinical presentations: a single center experience
Authors: Olgac Asburce , Kasapkara Çiğdem Seher , Derinkuyu Betül , Yüksel Deniz , Çetinkaya Semra , Aksoy Ayşe , Ceylaner Serdar , Güleray Naz , Yeşilipek Akif , Aydın Halil İbrahim , Orgun Leman Tekin , Kılıç Mustafa 
Published: June 2021

Abstract

Objectives
X-linked adrenoleukodystrophy (X-ALD), is a peroxisomal inborn error of metabolism caused due to the loss of function variants of ABCD1 gene that leads to accumulation of very long chain fatty acids (VLCFAs) in several tissues including the neurological system. Childhood cerebral X-ALD (CCALD) is the most common and severe form of X-ALD, if left untreated. Allogenic hematopoietic stem cell transplantation (HSCT) is the only available therapy that halts neurological deterioration in CCALD. We present 12 patients with several subtypes of X-ALD that were followed-up in a single center.

Methods
Data of 12 patients diagnosed with X-ALD were documented retrospectively. Demographics, age of onset, initial symptoms, endocrine and neurological findings, VLCFA levels, neuroimaging data, molecular genetic analysis of ABCD1 gene, and disease progress were documented.

Results
Mean age of initiation of symptoms was 7.9 years and mean age of diagnosis was 10.45 years. Eight patients had the CCALD subtype, while two had the cerebral form of AMN, one had the adult form of cerebral ALD, and one patient had the Addison only phenotype. The most common initial symptoms involved the neurological system. Loes scores varied between 0 and 12. Seven patients with CCALD underwent HSCT, among them three patients died. The overall mortality rate was 25%.

Conclusions
Patients with X-ALD should be carefully followed up for cerebral findings and progression, since there is no genotype–phenotype correlation, and the clinical course cannot be predicted by family history. HSCT is the only available treatment option for patients with neurological deterioration.
MAN1B1-CDG: novel patients and novel variant
Authors: Kasapkara Cigdem Seher , Olgac Asburce , Kilic Mustafa , Keldermans Liesbeth , Matthijs Gert , Jaeken Jaak 
Published: June 2021

Abstract

Objectives
Congenital disorders of glycosylation (CDGs) are a group of genetic disorders due to hypoglycosylation of proteins and lipids. A type I pattern is associated with defects in glycan assembly and transfer (CDG-I; cytosol; and endoplasmic reticulum defects), a type II pattern is seen in processing defects of the Golgi apparatus. MAN1B1-CDG is an autosomal recessive CDG-II due to mutations in the α 1,2-mannosidase gene (MAN1B1), mainly characterized by psychomotor disability, facial dysmorphism, truncal obesity, and hypotonia.

Case presentation
Three patients (two males and one female), with MAN1B1-CDG who had elevated transaminase levels are presented. All patients had presented due to dysmorphic and neurological findings and hypertransaminasemia was remarkable. A type 2 pattern was found on serum transferrin isoelectrofocusing analysis of the presented cases. MAN1B1-CDG was confirmed by genetic analysis.

Conclusions
Although the cause of the increased serum transaminase levels in the present patients is not clear, no evidence for an infection or underlying liver pathology could be identified. In order to know if this is a consistent feature, we suggest measuring serum transaminase levels regularly in MAN1B1-CDG patients.
Long non-coding RNA TUG1 aggravates cerebral ischemia and reperfusion injury by sponging miR-493-3p/miR-410-3p
Authors: Du Jinlong , Li Wenjing , Wang Bing 
Published: June 2021

Abstract

Background
Cerebral ischemia and reperfusion injury (CIRI) affects bodily function by causing irreversible damage to brain cells. The diverse pathophysiological course factors hinder the research work to go deeper. Long noncoding RNA taurine-upregulated gene 1 (TUG1) has been reported to be related to CIRI. This study explored the undefined regulatory pathway of TUG1 in CIRI.

Methods
Quantitative real-time polymerase chain reaction was applied to test the expression of TUG1, microRNA (miR)-493-3p and miR-410-3p. The viability and apoptosis of oxygen and glucose deprivation/reoxygen (OGD/R) model cells were evaluated by cell counting kit-8 and flow cytometry assay, respectively. The determination of inflammatory factors of interleukin-6, interleukin-1β and tumor necrosis factor-α was presented by enzyme-linked immunosorbent assay. The oxidative stress was performed by measuring the generation of malondialdehyde, reactive oxygen species and the activity of superoxide dismutase. Cytotoxicity was presented by measuring the generation of lactate dehydrogenase. Western blot assay was devoted to assessing the level of apoptosis-related factors (cleaved-caspase-3 and cleaved-caspase-9) and the protein level of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) pathway-related factors in neuro-2a cells treated by OGD/R. Besides, online database starBase was applied to predict the potential binding sites of TUG1 to miR-493-3p and miR-410-3p, which was further confirmed by the dual-luciferase reporter system.

Results
The expression of TUG1 was upregulated, while miR-493-3p or miR-410-3p was downregulated in the serum of CIRI and OGD/R model cells. Meanwhile, knockdown of TUG1 eliminated the suppression in proliferation, the promotion in apoptosis, inflammation and oxidative stress, as well as the cytotoxicity in OGD/R model cells. Interestingly, the inhibition of miR-493-3p or miR-410-3p allayed the above effects. In addition, TUG1 harbored miR-493-3p or miR-410-3p and negatively regulated their expression. Finally, the TUG1 activated JNK and p38 MAPK pathways by sponging miR-493-3p/miR-410-3p.

Conclusion
TUG1 motivated the development of CIRI by sponging miR-493-3p/miR-410-3p to activate JNK and p38 pathways. The novel role of TUG1 in CIRI may contribute to the advancement of CIRI treatment.
The secrets of cryptochromes: photoreceptors, clock proteins, and magnetic sensors
Authors: Bartölke Rabea , Behrmann Heide , Görtemaker Katharina , Yee Chad , Xu Jingjing , Behrmann Elmar , Koch Karl-Wilhelm 
Published: June 2021

Abstract
A class of light-activated proteins in the eyes of birds, called cryptochromes, are thought to act as the primary magnetic sensors allowing night-migratory songbirds to navigate over thousands of kilometers using the earth’s magnetic field. Having evolved from DNA-repairing photolyases, cryptochromes have redirected the energy from light to fuel a variety of other functions: as photoreceptors, as regulators of the circadian clock – and, in some species, most likely as sensors of the magnetic field. While the quantum effects of magnetic fields on cryptochromes are already being studied in detail, almost nothing is known about the signaling cascade involving cryptochrome as the primary receptor protein. Two different screening methods have identified potential interaction partners that suggest an involvement of the visual phototransduction pathway, the visual cycle, potassium channels or glutamate receptors, but more pioneering research is needed to unravel the signaling cascade responsible for transducing the magnetic signal.
The neuronal correlates of the avian magnetic senses
Authors: Haase Katrin , Musielak Isabelle , Heyers Dominik 
Published: June 2021

Abstract
In addition to other natural orientation cues such as the stars, the sun, landmarks and olfactory cues, migrating birds possess the ability to orient by the Earth’s magnetic field. In recent years, neuroscientific research has pinpointed brain regions and connecting neuronal pathways that seem to be involved in processing magnetic information. To date, the most compelling neuroanatomical and behavioural evidence comes from the visual and trigeminal sensory systems. We expect that navigational information from both systems could be integrated in higher-order brain structures, such as the hippocampus and the “decision-making” caudolateral nidopallium. This review summarizes the current state of research on the neurosensory basis of magnetoreception in birds.
Insertion of vowels in English syllabic consonantal clusters pronounced by L1 Polish speakers
Authors: Chwesiuk Urszula 
Published: June 2021

AbstractThe aim of this study was an attempt to verify whether Polish speakers of English insert a vowel in the word-final clusters containing a consonant and a syllabic /l/ or /n/ due to the L1–L2 transfer. L1 Polish speakers are mostly unaware of the existence of syllabic consonants; hence, they use the Polish phonotactics and articulate a vocalic sound before a final sonorant which is deprived of its syllabicity. This phenomenon was examined among L1 Polish speakers, 1-year students of English studies, and the recording sessions were repeated a year later. Since, over that time, they were instructed with regard to phonetics and phonology but also the overall practical language learning, the results demonstrated the occurrence of the phenomenon of vowel insertion on different levels of advanced command of English. If the vowels were inserted, their quality and length were monitored and analysed. With regard to the English system, pronouncing vowel /ə/ before a syllabic consonant is possible, yet not usual. That is why another aim of this study is to examine to what extent the vowels articulated by the subjects differ from the standard pronunciation of non-final /ə/. The quality differences between the vowels articulated in the words ending with /l/ and /n/ were examined as well as the potential influence from the difference between /l/ and /n/ on the occurrence of vowel reduction. Even though Polish phonotactics permit numerous consonantal combinations in all word positions, it proved to be challenging for L1 Polish speakers to pronounce word-final consonantal clusters containing both syllabic sonorants. This result carries practical implications for the teaching methodology of English phonetics.
High precision methods for solving a system of cold plasma equations taking into account electron–ion collisions
Authors: Chizhonkov Eugene V. , Delova Mariya I. , Rozanova Olga S. 
Published: June 2021

Abstract
High precision simulation algorithms are proposed and justified for modelling cold plasma oscillations taking into account electron–ion collisions in the non-relativistic case. The specific feature of the approach is the use of Lagrangian variables for approximate solution of the problem formulated initially in Eulerian variables. High accuracy is achieved both through the use of analytical solutions on trajectories of particles and due to sufficient smoothness of the solution in numerical integration of Cauchy problems. Numerical experiments clearly illustrate the obtained theoretical results. As a practical application, a simulation of the well-known breaking effect of multi-period relativistic oscillations is carried out. It is shown that with an increase in the collision coefficient one can observe that the breaking process slows down until it is completely eliminated.
Industrie 5.0 – ein menschzentrierter Ansatz
Authors: Tropschuh Barbara , Dillinger Fabian , Korder Svenja , Maier Maria , Gärtner Quirin , Vernim Susanne 
Published: June 2021

Abstract
Industrie 4.0 und die Digitalisierung beeinflussen mit ihren technologiezentrierten Entwicklungen produzierende Unternehmen positiv. Sie ermöglichen einen Umgang mit der zunehmenden Komplexität und Volatilität des Produktionsumfelds. Dabei steht nach wie vor die technologie- und wirtschaftlichkeitsgetriebene Ausrichtung dieser Trends im Vordergrund. Eine echte, vollständig menschzentrierte Entwicklung fehlt aktuell. Hier setzt das Konzept der Industrie 5.0 an. Dieser Beitrag stellt sechs Ansätze aus der Forschung vor, welche Unternehmen langfristig bei der Bewältigung aktueller Herausforderungen unterstützen und dabei den Menschen in den Mittelpunkt der Lösungsentwicklung rücken.
Sex and Pubertal Differences in the Maturational Trajectories of Sleep Spindles in the Transition from Childhood to Adolescence: A Population-Based Study
Authors: Ricci Anna , He Fan , Calhoun Susan L. , Fang Jidong , Vgontzas Alexandros N. , Liao Duanping , Bixler Edward O. , Younes Magdy , Fernandez-Mendoza Julio 
Published: June 2021

AbstractSleep spindles, bursts of electroencephalogram (EEG) activity in the σ-frequency (11–16 Hz) range, may be biomarkers of cortical development. Studies capturing the transition to adolescence are needed to delineate age-related, sex-related, and pubertal-related changes in sleep spindles at the population-level. We analyzed the sleep EEG of 572 subjects 6–21 years (48% female) and 332 subjects 5–12 years (46% female) followed-up at 12–22 years. From 6 to 21 years, spindle density (pquadratic = 0.019) and fast (12–16 Hz) spindle percent (pquadratic = 0.016) showed inverted U-shaped trajectories, with plateaus after 15 and 19 years, respectively. Spindle frequency increased (plinear < 0.001), while spindle power decreased (plinear < 0.001) from 6 to 21 years. The trajectories of spindle density, frequency, and fast spindle percent diverged between females and males, in whom density plateaued by 14 years, fast spindle percent by 16 years, and frequency by 18 years, while fast spindle percent and spindle frequency continued to increase until 21 years in females. Males experienced a longitudinal increase in spindle density 31% greater than females by 12–14 years (p = 0.006). Females experienced an increase in spindle frequency and fast spindle percent 2% and 41% greater, respectively, than males by 18–22 years (bothp = 0.004), while males experienced a 14% greater decline in spindle power by 18–22 years (p = 0.018). Less mature adolescents (86% male) experienced a longitudinal increase in spindle density 36% greater than mature adolescents by 12–14 years (p = 0.002). Overall, males experience greater maturational changes in spindle density in the transition to adolescence, driven by later pubertal development, and sex differences become prominent in early adulthood when females have greater spindle power, frequency, and fast spindle percent.