bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Mucosa-Associated Lymphoid Tissue Lymphoma in Midbrain: Case Report and Literature Review
Authors: Zhao Yongrui , Hu Ronghua , Wu Rui , Xu Jiankun 
Published: March 2021

Abstract
Background: Primary non-dural central nervous system (CNS) mucosa-associated lymphoid tissue (MALT) lymphoma is a rare indolent B-cell lymphoma, with only a few reported cases worldwide. Case presentation: This report presents the treatment of MALT lymphoma developing in the midbrain. The patient received radiotherapy, and the tumour was in complete remission. We also reviewed the literature on brain parenchymal-based MALT lymphoma, including the clinical presentation, treatment options and outcomes.Conclusions: Although there is no consensus on the optimal treatment for this rare disease, patients can respond well when treated with radiotherapy alone.
A Model of Atherosclerosis using Nicotine with Balloon Overdilation in a Porcine
Authors: Kim Munki , Kim Han Byul , Park Dae Sung , Cho Kyung Hoon , Hyun Dae Young , Kee Hae Jin , Hong Young Joon , Jeong MyungHo 
Published: March 2021

Abstract
Pigs are one of the important experimental animals for cardiovascular research. Few porcine coronary atherosclerosis models have been developed; however, the induction of which requires longer than 6 months. We developed a porcine coronary artery atherosclerosis model using nicotine injection with a balloon overdilation. A coronary balloon was placed in the porcine coronary artery and was over dilated to induce a mechanical injury. Nicotine was administrated via intramuscular injection every day and changes in the coronary artery were observed after 4 weeks. Coronary angiography revealed nicotine injection with a balloon overdilation groups showed narrowing of the coronary artery at the injury site. Combination of balloon and nicotine significantly increased the intimal hyperplasia on optical coherence tomography analysis. Proliferated tunica media was noted in the nicotine injection with balloon overdilation groups. Quantitative analysis showed increased smooth muscle actin alpha (SMA), cluster of differentiation 68 (CD68), and Krüppel-like factor 4 (KLF4) in the nicotine injection with balloon overdilation groups. The immunohistochemistry results showed CD68-positive cells displayed SMA- and KLF4-positive reactivity in the border zone of intimal hyperplasia. Our results show that nicotine injection with balloon overdilation can induce an atherosclerosis lesion within one month, which mimics the human atherosclerosis.
Association of Blood and Urine Parameter Value Change With the Amount of Consumed Water Regime and Sample Sampling in Healthy Individuals
Authors: Jovicic Snezana M 
Published: March 2021

Abstract
Background: Understanding the effect of pre-analytical factors is important for data quality of bio-specimens and health status. The study examines the effect of 9-days fluid intake and 2-time sampling on concentration changes of 7-Urine and 17-Blood variables. Material and Method: SPSS software v23.0 applies to data processing. The group of 23 healthy subjects divide based on water intake and gender. Results: A statistically significant difference(p<0.01) between 1st/2nd sampling is confirmed for Freezing point depression, Sodium, Potassium, Creatinine Urea and Urate in Urine and Urea, Urate, Glucose, Hematocrit, Thrombocyte in Blood. The difference between water intake after 1st sampling is confirmed (p<0.01) for Freezing point depression, Sodium, Urate and(p<0.05) for Potassium(p<0.05), Chloride(p<0.05), Creatinine(p<0.05), Urate, Urea in Urine and Potassium(p<0.01) and Chloride(p<0.05) in Blood. Difference between gender exists for Urea(p<0.05) in Urine after 2nd sampling and Urate(P<0.01), Glucose(p<0.01/0.05), Ht(p<0.01/0.05) after 1st and 2nd sampling and MCHC(p<0.01) after 2nd sampling in Blood samples.Conclusion: Water intake increases blood and urine biomarker range after sampling.
Serum Albumin Was Negatively Associated With Diabetic Peripheral Neuropathy in Chinese Population: A Cross-sectional Study
Authors: yan pijun , Tang Qian , Wu Yuru , Wan Qin , Zhang Zhihong , Xu Yong , Zhu Jianhua , Miao Ying 
Published: March 2021

Abstract
Background: Studies that investigated the association between serum albumin and the risk of diabetic peripheral neuropathy (DPN) have reported inconsistent results. The objective of this study was to explore the relationship between serum albumin and DPN in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: Serum albumin levels were measured in 1465 patients with T2DM aged 16–89 years. The relationships between serum albumin and the prevalence of DPN and other parameters were analyzed. Results: Patients in the highest quartile of serum albumin had lower prevalence of DPN compared with subjects in the lowest quartile (P <0.01). Serum albumin was positively associated with DBP, total cholesterol, triglycerides, high-density lipoprotein cholesterol, uric acid, and negatively with glycated hemoglobin A1c, γ-glutamyltransferase, cystatin C, serum creatinine, albumin- to-creatinine ratio, neutrophil-to-lymphocyte ratio, vibration perception thresholds (VPT), and prevalence of DPN after adjustments for age, gender, body mass index, and diabetic duration ( P<0.01 or P<0.05). There was an 50.1% decreased risk of DPN (95% confidence interval [CI] 0.404-0.544; P <0.01) per 1 SD increase of serum and 62.7% decreased risk of DPN in quartile 4 of serum albumin versus quartiles 1, 2, and 3 (95% CI 0.195-0.714; P=0.003) after multivariate adjustment. Serum albumin could predict DPN with 65.88% sensitivity and 66.7% specificity for the best cutoff value of 39.95 g/L. Conclusions: These findings suggest that lower serum albumin might be associated with the presence of DPN via increased oxidative stress, inflammation, and vasculopathy. Further larger and prospective studies are needed to confirm our findings.
Applications of Machine Learning to Predict Cisplatin Resistance in Lung Cancer
Authors: Gao Yanan , Lyu Qiong , Zhou Rui , Luo Peng , Zhang Jian , Lyu Qingwen 
Published: March 2021

Abstract
Background: Lung cancer, mainly including lung adenocarcinoma, lung squamous cell carcinoma and small cell lung cancer, is the cancer with the highest incidence and cancer-related mortality in the world. Platinum-based chemotherapy plays an important role in the treatment of various lung cancer subtypes, but not all patients can benefit from it, so it is worth identifying lung cancer patients who are resistant or insensitive.Method: The drug response and sequencing data of 170 lung cancer cell lines were downloaded from the Genomics of Drug Sensitivity in Cancer (GDSC) database, and support vector machines (SVMs) and beam search were used to select an optimal gene panel that can predict the sensitivity of cell lines to cisplatin. Then, we used the available cell line data to explore the potential mechanisms.Result: In this study, SVMs and beam search were used to screen a 9-gene panel related to lung cancer cell line resistance to cisplatin, with an area under the curve (AUC) of 0.873 ± 0.004. The natural logarithm of the half maximal inhibitory concentration (lnIC50) values of the panel-MT group were significantly higher than those of the panel-WT group, regardless of whether lung cancer subtype was considered. In addition, we found that the differentially expressed pathways between the two groups may explain the difference.Conclusion: In this study, we found that a panel including nine genes (PLXNC1, KIAA0649, SPTBN4, SLC14A2, F13A1, COL5A1, SCN2A, PLEC, and ALMS1) can accurately predict sensitivity to cisplatin, which may provide individualized treatment recommendations to improve the prognosis of patients with lung cancer.
Quantitative Mapping of Individual Voxels in the Peritumoral Region of Glioblastoma to Distinguish Between Tumor Infiltration and Edema
Authors: Dasgupta Archya , Geraghty Benjamin , Maralani Pejman Jabehdar , Malik Nauman , Sandhu Michael , Detsky Jay , Tseng Chia-Lin (Eric) , Soliman Hany , Myrehaug Sten , Husain Zain , Perry James , Lau Angus , Sahgal Arjun , Czarnota Gregory 
Published: March 2021

Abstract
Purpose: The peritumoral region (PTR) in glioblastoma (GBM) represents a combination of infiltrative tumor and vasogenic edema, which are indistinguishable on magnetic resonance imaging (MRI). We developed a radiomic signature by using imaging data from low grade glioma (LGG) (marker of tumor) and PTR of brain metastasis (BM) (marker of edema) and applied it on the GBM PTR to generate probabilistic maps. Methods: 270 features were extracted from T1-weighted, T2-weighted, and apparent diffusion coefficient maps in over 3.5 million voxels of LGG (36 segments) and BM (45 segments) scanned in a 1.5 T MRI. A support vector machine classifier was used to develop the radiomics model from approximately 50% voxels (downsampled to 10%) and validated with the remaining. The model was applied to over 575,000 voxels of the PTR of 10 patients with GBM to generate a quantitative map using Platt scaling (infiltrative tumor vs. edema). Results: The radiomics model had an accuracy of 0.92 and 0.79 in the training and test set, respectively (LGG vs. BM). When extrapolated on the GBM PTR, 9 of 10 patients had a higher percentage of voxels with a tumor-like signature over radiological recurrence areas. In 7 of 10 patients, the areas under curves (AUC) were >0.50 confirming a positive correlation. Including all the voxels from the GBM patients, the infiltration signature had an AUC of 0.61 to predict recurrence.Conclusion: A radiomic signature can demarcate areas of microscopic tumors from edema in the PTR of GBM, which correlates with areas of future recurrence.
Protocol for a Systematic Review of the Effectiveness of Provider-targeted Interventions to Improve Opioid Prescribing in Primary Care
Authors: Prathivadi Pallavi , Connell Natalie , Picco Louisa , Giannitrapani Karleen F , Wong Hong-nei , Barton Chris , Lorenz Karl , Mazza Danielle 
Published: March 2021

Abstract
Background: Improving primary care opioid prescribing is a public health priority in many western nations. Governments, policymakers and key stakeholders are intervening on multiple levels to address patient, prescriber and systems factors contributing to opioid over-prescription in primary care. Many opioid prescribing interventions specifically target primary care providers (PCPs); however, the overall effectiveness of these interventions is not known. Identifying effective components of PCP-targeted behaviour change interventions may help inform scalability and translation of prescribing interventions across countries and varying primary healthcare settings. The aim of this systematic review is to assess the effectiveness of provider-targeted interventions to improve opioid prescribing in primary care. This protocol reports the methods of the proposed narrative synthesis review that will be guided by the Theoretical Domains Framework (TDF). Methods: The study will follow Cochrane methods for conducting a narrative synthesis. Reporting is compliant with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocols. The review will conduct searches in PubMed, EMBASE, PsychInfo, CINAHL, and the Cochrane Library databases for studies published in the English language from 2010 onwards. Reference lists of accepted articles will be also screened for additional studies meeting inclusion. Any opioid prescribing behaviour will be measured as an outcome. Intervention components will be mapped to domains of the TDF. No geographic limits will be applied. All stages of screening and data extraction will involve a dual review with gold standard adjudication. The Cochrane Risk of Bias tool will be used to evaluate quality and risk. Discussion: This review is being conducted in strict adherence to Cochrane principles. The protocol was submitted for registration to Prospero prior to publication for transparency and to avoid duplication of research. Formal ethics approval is not required for this research. The findings of this review will inform the delivery and implementation of PCP targeted opioid prescribing interventions. Findings will be disseminated to a wide range of stakeholders involved in quality improvement, prescribing interventions, education and training; professional groups, policymakers, researchers and PCPs.Systematic review registration: Submitted to Prospero 22 December 2020; pending registration
Device and non-device-guided slow breathing to reduce blood pressure in hypertensive patients: a systematic review protocol
Authors: Gonçalves Kamila Shelry de Freitas , Daniel Ana Carolina Queiroz Godoy , Lamas José Luiz Tatagiba , Silveira Renata Cristina De Campos Pereira , Cloutier Lyne , Veiga Eugenia Velludo 
Published: March 2021

Abstract
IntroductionPhysiotherapy can include both device-guided slow breathing and device-guided slow breathing in the treatment of systemic arterial hypertension. MethodsA systematic search of all published randomized controlled trials on the effects of device-guided and non-device-guided slow breathing on hypertensive patients, without language restriction, will be carried out until January 2020 in nine databases: Pubmed / MEDLINE (Medical Literature Analysis and Retrieval System Online), Latin American and Caribbean Health Sciences Literature (LILACS), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Physiotherapy Evidence Database (PEDro), Cumulative Index to Nursing and Allied Health Literature ( CINAHL), Scopus, Web of Science, Livivo, as well as a search of clinical trial records databases, CT.GOV (Clinical trials.Gov), and bases for the Open Grey gray literature, Gray Literature Report, ProQuest Central (Citation, Abstract or Indexing and Dissertations and Theses). In all of these databases, potentially eligible studies including completed and ongoing ECAs were researched. The quality assessment of the included studies will be conducted using the Cochrane Risk of Bias Tool for Randomized Trials. The overall quality of the evidence for each outcome will be assessed using the Grading of Recommendations, Development and Evaluation (GRADE) system. DiscussionThis systematic review will provide a summary of the current evidence on the effects of both device-guided slow breathing and device-guided slow breathing on blood pressure levels. This information can contribute to decision making by health professionals related to the use of these interventions in hypertensive patients. Following the guidelines, this systematic review protocol was registered with the Prospective International Register of Systematic Reviews (PROSPERO) number CRD42020147554.
Investigation of Pharmacological Mechanism of Natural Product Using Pathway Fingerprints Similarity Based on “Drug-Target-Pathway” Heterogenous Network
Authors: Guo Feifei , Jiang Chunhong , Xi Yujie , Wang Dan , Zhang Yi , Xie Ning , Guan Yi , Zhang Fangbo , Yang Hongjun 
Published: March 2021

Abstract
Natural products from traditional medicine inherit bioactivity from their source herbs. However, the pharmacological mechanism of natural products is often unclear and studied insufficiently. Pathway fingerprint similarity based on “drug-target-pathway” heterogeneous network provides new insight into Mechanism of Action (MoA) for natural products compared with reference drugs, which are selected approved drugs with similar bioactivity. Natural products with similar pathway fingerprints may have similar MoA to approved drugs. In our study, XYPI, an andrographolide derivative, had similar anti-inflammatory activity to Glucocorticoids (GCs) and Nonsteroidal Anti-inflammatory Drugs (NSAIDs), and GCs and NSAIDs have completely different MoA. Based on similarity evaluation, XYPI has similar pathway fingerprints as NSAIDs, but has similar target profile with GCs. The expression pattern of genes in LPS-activated macrophages after XYPI treatment is similar to that after NSAID but not GC treatment, and this experimental result is consistent with the computational prediction based on pathway fingerprints. These results imply that the pathway fingerprints of drugs have potential for drug similarity evaluation. This study used XYPI as an example to propose a new approach for investigating the pharmacological mechanism of natural products using pathway fingerprint similarity based on a “drug-target-pathway” heterogeneous network.
Prevalence of HER2 overexpression and amplification in uterine cervical cancer: a systematic review and a meta-analysis.
Authors: Itkin Boris , Garcia Agustin , Straminsky Samanta , Adelchanow Eduardo Daniel , Pereyra Matias , Haab Gabriela Acosta , Bardach Ariel 
Published: March 2021

Abstract
BackgroundThe reported rates of HER2 positivity in uterine cervical cancer (CC) range from 0–87%. The organization of clinical studies of HER2 targeting agents in CC requires a better knowledge of HER2 positivity prevalence. We aimed to provide precise estimates of HER2 overexpression and amplification in CC.MethodsWe conducted a PRISMA compliant meta-analytic systematic review. We searched electronic databases for articles reporting the proportion of HER2 positivity by immunohistochemistry or in situ hybridization in CC. We performed descriptive analyses of all 65 included studies. Of these, we selected 26 studies that used standardized American Society of Clinical Oncology / College of American Pathologists (ASCO/CAP) Guidelines compliant methodology. We conducted several meta-analyses of proportions to estimate the pooled prevalence of HER2 positivity and subgroup analyses using geographic region, histology, tumor stage, primary antibody brand, study size, and publication year as moderators.ResultsThe estimated pooled prevalence of HER2 overexpression was 5.7% (CI 95%: 1.5–11.7%) in ASCO/CAP compliant studies and 27.0%, (CI 95%: 19.9–34.8%) in ASCO/CAP non-compliant ones, p < 0.001. The estimated pooled prevalence of HER2 amplification was 1.2% (CI 95%: 0.0–5.8%) and 24.9% (CI 95%: 12.6–39.6%), respectively, p = 0.004. No other factor was significantly associated with HER2 positivity rates.ConclusionA small proportion of CC is expected to be HER2 positive. Variations in previously reported HER2 positivity rates are mainly related to methodological issues.
Financial Inclusion Gender Gap in Ethiopia: Evidence from Decomposition Analysis
Authors: Hundie Shemelis Kebede , Tulu Daniel Tadesse 
Published: March 2021

Abstract
Financial inclusion gender gap in Ethiopia is significantly high and how socioeconomic variables affect the gap is not sufficiently studied. Hence, this study examines financial inclusion gender gap in Ethiopia using the World Bank’s Global Findex database of 2017. Hence, this study aims to examine the magnitude of financial inclusion gender gap and its socioeconomic determinants in Ethiopia using different econometric decomposition analysis. Empirical findings denote that there is statistically significant financial gender disparity in Ethiopia. Fairlie decomposition results show that being older, a man, more educated and richer favor financial inclusion with a higher influence of age, employment and education. Moreover, differences in coefficients, differences in productivity, advantage to males and disadvantage to females widen the gender gap in financial inclusion Ethiopia.
Role of Pulmonary Ultrasound in COVID-19 Pandemics
Authors: Starostin Daniil , Kuzovlev Artem 
Published: March 2021

:
Currently, there is a lot of clinical data on the basics of lung ultrasound (US) examination
in patients with COVID-19. This article is focused on the principles of pneumonia diagnosis.
It is established that the use of ultrasound can be informative at the prehospital stage and triage of
patients and also detection of mild forms of the course of the disease.
Analisis Kebutuhan Media Promosi Kesehatan Layanan Provider Initiated Testing and Counseling (PITC) bagi Ibu Hamil
Authors: Maydianasari Lenna - , Ratnaningsih Ester - 
Published: March 2021

Latar Belakang: Kasus HIV pada ibu hamil di Kabupaten Sleman pada tahun 2018 sebanyak 23 kasus dan meningkat menjadi 75 kasus pada tahun 2019. Setiap ibu hamil sudah diwajibkan untuk dilakukan tes HIV melalui layanan PITC. Namun, media promosi kesehatan tentang layanan PITC belum tersedia, sehingga ibu hamil belum memahami pentingnya layanan tersebut dan pencegahan HIV/AIDS.Tujuan: Untuk menganalisis kebutuhan media promosi kesehatan layanan PITC bagi ibu hamil.Metode: Penelitian ini merupakan penelitian penjelasan (explanatory research) dengan pendekatan kuantitatif untuk meneliti karaktersitik responden dan informasi layanan PITC serta pendekatan kualitatif untuk kebutuhan media promosi kesehatan layanan PITC. Teknik pengumpulan data dengan kuesioner dan panduan wawancara mendalam. Analisis data menggunakan analisis deskriptif dan analisis isi (content analysis).Hasil: Mayoritas responden berusia 20-35 tahun, pendidikan menengah, ibu rumah tangga, primigravida dan umur kehamilan trimester III. Media promosi kesehatan layanan PITC diperlukan untuk mempermudah penyampaian informasi bagi ibu hamil dan suaminya (51,7%). Bentuk pesan dan media yaitu audiovisual (87,1%) dan jenis media sosial (75,3%). Kesimpulan: Media promosi kesehatan layanan PITC bagi ibu hamil yang dibutuhkan adalah media audiovisual yang disampaikan melalui media sosial. Media tersebut dapat diintegrasikan dengan strategi promosi serta komunikasi kesehatan efektif untuk pencegahan HIV/AIDS pada kehamilan.
Muito além das imagens e Reengenharia da Cultura nos games, jornalismo operativo e sistemas enativos em práticas colaborativas transdisciplinares de Arte e TecnoCiência
Authors: Domingues Diana , Novaes Dulcinéia , Maschio Liliam Beatriz 
Published: March 2021

A imagem, na revolução antropológica, vinda do ciberespaço misturado à vida, afasta-se da categoria de artefato para configurar eventos comunicacionais biocíbridos. As experiências do cotidiano se expandem para fora das fronteiras da tela, trazendo a ciência da interface mesclada aos cenários da Reengenharia da Cultura. Consideramos jogos, jornalismo operativo, sistemas enativos afetivos e redes sociais na Arte e Tecnociência, relacionados também à saúde e ao bem-estar. A partir da proposta ampliada de Benjamin, em relação ao "autor como produtor digital", nas trocas dos ambientes digitais, propomos feedbacks complexos, respostas autônomas, dispositivos sensoriais e a influência mútua dos corpos, ambiente e dados, trazendo a cognição incorporada em episódios e ocorrências misturadas à vida. As abordagens transdisciplinares enfrentam os desafios da vida do planeta, para além da imagem, configurando experiências estéticas e relações com sistemas enativos em graus de ubiquidade, mobilidade, liberdade e locatividade. Estamos discutindo os desafios da comunicação em um mundo tecnologicamente dependente, por meio de ontologias criativas pós-biológicas, em estudos de caso de nossas pesquisas. Os principais focos de análise são os limites borrados da vida e do ciberespaço numa “realidade reengenheirada”.