bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing the Number of Faculty With CNE® Certification: A Statewide Initiative
Authors: Daw Peggy , Seldomridge Lisa A. , Ford Kimberly , D’Aoust Rita 
Published: December 2021

Abstract
This article describes outcomes of a statewide initiative to increase the number of faculty with the National League for Nursing’s Certified Nurse Educator (CNE®) credential. After offering CNE preparation workshops and creating a certification award, data were collected on perceived workshop effectiveness, readiness to test, certification pass rates, and characteristics of award recipients. The number of certified faculty increased by 92.3 percent, representing 24 of 28 nursing programs. Maryland faculty were awarded $625,000 through the Academic Nurse Educator Certification award.
Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines
Authors: Gluvic Zoran , Tomasevic Ratko , Bojovic Ksenija , Obradovic Milan , Isenovic Esma R. 
Published: December 2021

Abstract
Non-alcoholic fatty liver disease (NAFLD) is among the most frequently encountered chronic liver diseases in everyday clinical practice. It is considered the hepatic manifestation of metabolic syndrome. Today, liver biopsy is still the gold standard for NAFLD confirmation and assessing NAFLD's possible progression to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Because of the high prevalence of NAFLD and potential associated risks of invasive diagnostic procedures, it is of great interest to recruit the patients for liver biopsy. However, as the presence of liver fibrosis determines the further clinical course, liver biopsy is expectedly reserved for those with increased fibrosis risk. The quality of liver biopsy recruitment and patient monitoring could be significantly improved by using non-invasive tools to assess liver fibrosis presence and interactive collaboration between general practitioners, gastroenterologists, and endocrinologists. As a result, the quality of liver biopsy recruitment and patients monitoring could be significantly improved. Here, we proposed clinical practice guidelines that could be implemented for everyday clinical practice in NAFLD patients.
Sulforaphane Effects on Cardiac Function and Calcium-Handling–Related Proteins in 2 Experimental Models of Heart Disease: Ischemia-Reperfusion and Infarction
Authors: Poletto Bonetto Jéssica Hellen , Luz de Castro Alexandre , Fernandes Rafael Oliveira , Corssac Giana Blume , Cordero Elvira Aparicio , Schenkel Paulo Cavalheiro , Sander da Rosa Araujo Alex , Belló-Klein Adriane 
Published: December 2021

Abstract:
Sulforaphane (SFN) is a natural exogenous antioxidant from cruciferous vegetables already shown to improve cardiac function in cardiovascular diseases. The aim of this study was to analyze the effect of SFN treatment on the cardiac function in 2 experimental models of heart disease, ischemia/reperfusion (I/R) and myocardial infarction (MI), and whether an improvement of the cardiac function could be associated with a modulation of calcium-handling proteins. The study was divided into 2 main experiments: experiment 1, ex vivo with the I/R model and experiment 2, in vivo with the MI model. In the I/R model, rats were divided into control and SFN (0.5 mg/kg/d intraperitoneally for 3 days) groups, and the hearts were submitted to global ischemia (20 minutes) followed by reperfusion (20 minutes) in a Langendorff apparatus. SFN did not change left ventricle systolic and diastolic pressures but increased the contractility and relaxation indexes after 20 minutes of reperfusion. These functional changes were accompanied by a decreased protein expression of ryanodine receptor (RyR) and increased expression of p-phospholamban/phospholamban ratio, without alteration in the sarco/endoplasmic calcium ATPase expression. In the MI model, rats were randomly divided into Sham, MI (MI induced by left coronary artery ligation), Sham + SFN (5 mg/kg/d intraperitoneally for 25 days), and MI + SFN groups. Although SFN did not affect cardiac function, it led to a decreased RyR protein expression and reactive oxygen species levels in the left ventricular of the MI + SFN group. These data indicate that SFN modulates calcium-handling proteins and, thus, cardiac inotropism/lusitropism especially when administered previously to an ischemic event.
Safety and Efficacy of Periprocedural Bridging With Cangrelor Versus Eptifibatide
Authors: Yun Allison N. , Toyoda Alex Y. , Solomon Edmond J. , Roberts Russel J. , Ji Christine S. 
Published: December 2021

Abstract:
Patients with percutaneous coronary interventions undergoing procedures often require interruptions in their dual antiplatelet therapy. Periprocedural bridging is considered for patients at high thrombotic risk using intravenous cangrelor, a reversible P2Y12 inhibitor with a short half-life, or eptifibatide, a glycoprotein IIb/IIIa inhibitor, with a slightly longer half-life but less costly alternative. This study aims to assess the safety and efficacy of cangrelor compared with eptifibatide when used in a periprocedural setting. The primary outcome of this retrospective cohort study was the incidence of bleeding events defined by the global use of strategies to open occluded coronary arteries criteria, and the secondary outcomes include the transfusion requirements, inpatient major cardiac adverse events, and cost savings per patient. A total of 75 patients were included who were bridged to procedures (cangrelor, n = 50; eptifibatide, n = 25). There were no significant differences in overall bleeding events defined by global use of strategies to open occluded coronary arteries criteria: mild bleeding [8% (n= 4) vs. 8% (n= 2); P = 0.68], moderate bleeding [28% (n = 14) vs. 48% (n = 12); P = 0.07), and severe bleeding [8% (n = 4) vs. 8% (n = 2); P = 0.25] between cangrelor and eptifibatide. The composite inpatient major cardiac adverse events were also similar between cangrelor and eptifibatide [10% (n = 10) vs. 8% (n = 8); P = 0.78]. The average cost savings per each cangrelor patient on the equivalent duration of eptifibatide was calculated out to be $5824 per patient. Cangrelor and eptifibatide were similar in terms of safety and efficacy when used as a bridge in patients with recent coronary stents, but considerable cost savings could be made if cangrelor was substituted for by eptifibatide in select patients. Further studies are needed to determine its applicability specifically in patients at high thrombotic and hemorrhagic risk.
Periprocedural Antithrombotic Treatment in Complex Percutaneous Coronary Intervention
Authors: Vlachakis Panayotis K. , Varlamos Charalampos , Benetou Despoina-Rafailia , Kanakakis Ioannis , Alexopoulos Dimitrios 
Published: December 2021

Abstract:
In recent years, the management of complex lesions in patients undergoing percutaneous coronary intervention (PCI) constitutes a field of high interest and concern for the interventional cardiology. As more and more studies demonstrate the increased hazard of ischemic events in this group of patients, it is of paramount importance for the physicians to choose the optimal periprocedural (pre-PCI, during-PCI and post-PCI) antithrombotic treatment strategies wisely. Evidence regarding the safety and efficacy of current anticoagulation recommendation, the possible beneficial role of the pretreatment with a potent P2Y12 inhibitor in the subgroup of patients with non-ST segment elevation myocardial infarction with complex lesions, and the impact of a more potent P2Y12 inhibitor in individuals with stable coronary artery disease undergoing complex PCI are needed. This will provide and serve as a guide to clinicians to deploy the maximum efficacy of the current choices of antithrombotic therapy, which will lead to an optimal balance between safety and efficacy in this demanding clinical scenario.
N-Tertaining a New Signaling Paradigm for the Cardiomyocyte β1-Adrenergic Receptor
Authors: Steinberg Susan F. 
Published: December 2021

Abstract:
β1-adrenergic receptors (β1ARs) are the principle mediators of catecholamine actions in cardiomyocytes. β1ARs rapidly adjust cardiac output and provide short-term hemodynamic support for the failing heart by activating a Gs-adenylyl cyclase pathway that increases 3’-5’-cyclic adenosine monophosphate and leads to the activation of protein kinase A and the phosphorylation of substrates involved in excitation–contraction coupling. However, chronic persistent β1AR activation in the setting of heart failure leads to a spectrum of maladaptive changes that contribute to the evolution of heart failure. The molecular basis for β1AR-driven maladaptive responses remains uncertain because chronic persistent β1AR activation has been linked to the activation of both proapoptotic and antiapoptotic signaling pathways. Of note, studies to date have been predicated on the assumption that β1ARs signal exclusively as full-length receptor proteins. Our recent studies show that β1ARs are detected as both full-length and N-terminally truncated species in cardiomyocytes, that N-terminal cleavage is regulated by O-glycan modifications at specific sites on the β1AR N-terminus, and that N-terminally truncated β1ARs remain signaling competent, but their signaling properties differ from those of the full-length β1AR. The N-terminally truncated form of the β1AR constitutively activates the protein kinase B signaling pathway and confers protection against doxorubicin-dependent apoptosis in cardiomyocytes. These studies identify a novel signaling paradigm for the β1AR, implicating the N-terminus as a heretofore-unrecognized structural determinant of β1AR responsiveness that could be pharmacologically targeted for therapeutic advantage.
Efficacy and Safety of Cilostazol for Atherosclerosis: A Meta-analysis of Randomized Controlled Trials
Authors: Wan Hongbing , Huang Tieqiu , Yang Pingping , Wu Tao , Zhang Hongzhou , Wu Qinghua 
Published: December 2021

Abstract:
To investigate the efficacy and safety of cilostazol for atherosclerosis. PubMed, Embase, and the Cochrane Central Register of Controlled Trials from inception to May 29, 2021, were searched for randomized clinical trials (RCTs). Ten trials with 1577 patients were included. Treatment with cilostazol significantly reduced carotid intima–media thickness [mean difference (MD), −0.12 mm; 95% confidence interval (CI), −0.17 to −0.06]. According to the difference in intervening measures, the cilostazol group was superior to the control group in inhibiting the progression of carotid intima–media thickness: cilostazol versus placebo (MD, −0.04 mm; 95% CI, −0.06 to −0.02; P < 0.00001), cilostazol versus no antiplatelet drug (MD, −0.14 mm; 95% CI, −0.26 to −0.03; P = 0.02), cilostazol versus aspirin (MD, −0.17 mm; 95% CI, −0.32 to −0.02; P = 0.02), cilostazol + aspirin versus aspirin (MD, −0.08 mm; 95% CI, −0.14 to −0.02; P = 0.007), cilostazol + aspirin versus clopidogrel + aspirin (MD, −0.07 mm; 95% CI, −0.14 to −0.00; P = 0.04), and cilostazol + clopidogrel + aspirin versus clopidogrel + aspirin (MD, −0.16 mm; 95% CI, −0.30 to −0.02; P = 0.03). Cilostazol treatment considerably decreased triglyceride (MD, −20.18 mg/dL; 95% CI, −39.03 to −1.34) and improved high-density lipoprotein cholesterol (MD, 4.35 mg/dL; 95% CI, 2.61–6.10). Cilostazol therapy significantly increased the risk of adverse events of headache (odds ratio, 12.91; 95% CI 5.33–31.29). Our research has revealed that cilostazol has potent antiatherosclerotic effects and can reverse atherosclerosis progress even in high-risk patients, such as those with type 2 diabetes mellitus, and does not increase the risk of bleeding.
Understanding the Pharmacokinetics of Antibiotics in Pregnancy: Is There a Role for Therapeutic Drug Monitoring? A Narrative Review
Authors: Stojanova Jana , Arancibia Marcelo , Ghimire Samiksha , Sandaradura Indy 
Published: December 2021

Purpose:
Antibiotics are commonly used during pregnancy. However, physiological changes during pregnancy can affect the pharmacokinetics of drugs, including antibiotics, used during this period. Pharmacokinetic evaluations have shed light on how antibiotics are affected during pregnancy and have influenced dosing recommendations in this context.

Methods:
A narrative review was conducted and included reports providing data reflecting drug distribution and exposure in the context of pregnancy.

Results:
Pharmacokinetic parameters of antibiotics in pregnancy and transplacental passage of antibiotics are comprehensively presented.

Conclusions:
Knowledge about the impact on pharmacokinetics and fetal exposure is especially helpful for complicated or severe infections, including intra-amniotic infection and sepsis in pregnancy, where both mother and fetus are at risk. Further studies are warranted to consolidate the role of therapeutic drug monitoring in complicated or severe infections in pregnant patients.
Factors Influencing Turnover Intention Among Operating Room Nurses in South Korea
Authors: GU Minkyung , KIM Yeong Seung , SOK Sohyune 
Published: December 2021

ABSTRACT

Background
Operating room nurses experience verbal abuse, high levels of job stress, and burnout that may increase turnover intention.

Purpose
This study was designed to investigate and identify factors influencing turnover intention among operating room nurses in South Korea.

Methods
This study used a cross-sectional descriptive design. The sample included 193 nurses, all of whom had over 3 months of work experience at operating rooms in hospitals in Seoul, South Korea. Measures used included the Verbal Abuse Experience Scale, Job Stress Scale, Burnout Scale, and Turnover Intention Scale.

Results
Burnout was found to have the greatest influence on turnover intention (β = .34, p < .001), followed by verbal abuse (β = −.23, p = .004), job stress (β = .22, p = .001), age (β = −20, p = .032), and job satisfaction (β = −.14, p = .020).

Conclusions/Implications for Practice
The findings support burnout and verbal abuse, respectively, as the most significant and second most significant predictors of turnover intention among operating room nurses in South Korea. These factors should be proactively and effectively addressed to reduce turnover intention in this important group of healthcare professionals.
Building the Science to Guide Nursing Administration and Leadership Decision Making
Authors: Joseph M. Lindell , Nelson-Brantley Heather V. , Caramanica Laura , Lyman Bret , Frank Betsy , Hand Mikel W. , Parchment Joy , Ward Danielle M. , Weatherford Barbara , Chipps Esther 
Published: December 2021

OBJECTIVE
The aim of this study was to identify the challenges, barriers, and solutions for conducting nursing administration and leadership science (NALS) research.

BACKGROUND
Evidence from leadership science should be at the forefront of nurse leaders' decision making. Yet, challenges remain in building the evidence and moving it into nursing administration and leadership practice.

METHODS
This study used a Delphi technique with open-ended questions and direct content analysis to evaluate survey responses of members of the Association for Leadership Science in Nursing and American Organization for Nursing Leadership.

RESULTS
Open-ended responses were coded to yield super categories and supportive codes for areas with limited evidence to guide leadership practice and the challenges for conducting NALS research.

CONCLUSIONS
These findings provide future directions for continuously driving NALS research and for building and leveraging leadership science to support nursing administration decision making.
A Survey of Interim Nurse Managers to Understand the Role and the Impact on Nurse and Patient Outcomes
Authors: Galura Sandra , Warshawsky Nora , Hu Wenfang , Utt Leah 
Published: December 2021

OBJECTIVE
The aim of this study was to describe the current state of the interim manager (IM) role and the impact of the role on job performance.

BACKGROUND
Interim managers provide leadership during organizational change, yet little is known about the role and its impact on outcomes.

METHODS
An electronic survey was completed by 179 IMs working in acute care hospitals. Instruments included the Nurse Manager Practice Environment Scale, Decision Involvement Scale, Subjective Stress Scale, Maslach Burnout Inventory, and Brief Resilience Scale.

RESULTS
The average tenure for IMs was 10 months. Despite moderately high levels of stress and exhaustion, IMs were resilient, positively viewed their work environment, and perceived their job performance as positively impacting nurse and patient outcomes. Interim managers were generally satisfied in their roles and likely to pursue nursing leadership as a career.

CONCLUSION
Interim managers desire permanent leadership opportunities providing a pool for replacing exiting nurse managers. Support is needed to be successful.
Normative Data for Parameters of Accommodation in African Schoolchildren
Authors: Darko-Takyi Charles , Moodley Vanessa R. , Boadi-Kusi Samuel B. 
Published: December 2021

SIGNIFICANCE
The reported interracial differences in normative data for parameters of accommodation call for investigating population-specific normative values. The study investigated and presents expected data for accommodative parameters among Ghanaian children.

PURPOSE
This study aimed to determine expected values for parameters of accommodation among schoolchildren in the Central Region of Ghana.

METHODS
This prospective cross-sectional study used a multistage cluster sampling approach. Normal participants were asymptomatic (Convergence Insufficiency Symptom Survey score ˂16), with unaided visual acuity or best-corrected visual acuity of 0.0 or better logMAR for each eye and having no ocular disease or no manifest strabismus. Normal participants underwent push-up and minus-lens-to-blur amplitude of accommodation tests, accuracy of accommodative response (using the monocular estimation method), and monocular and binocular accommodative facility testing.

RESULTS
A total of 1261 normal participants within ages 11 to 17 years (mean, 14.75 ± 1.53 years) met the inclusion criteria. The mean normative data for the population include push-up amplitude of accommodation (14.04 ± 2.95 D), minus-lens-to-blur amplitude of accommodation (12.33 ± 2.55 D), and accuracy of accommodative response using the monocular estimation method (0.62 ± 0.22 D), monocular accommodative facility (9.80 ± 3.20 cycles per minute), and binocular accommodative facility (9.40 ± 3.30 cycles per minute). Age-predicted linear regression equations for the amplitude of accommodation are push-up amplitude of accommodation (16.74 − 0.18 × age in years) and minus-lens-to-blur amplitude of accommodation (15.7 − 0.23 × age in years).

CONCLUSIONS
The study provides normative data for accommodative parameters that clinicians may use with Ghanaian populations of similar ages.
Automatic Screening for Ocular Anomalies Using Fundus Photographs
Authors: Matta Sarah , Lamard Mathieu , Conze Pierre-Henri , Le Guilcher Alexandre , Ricquebourg Vincent , Benyoussef Anas-Alexis , Massin Pascale , Rottier Jean-Bernard , Cochener Béatrice , Quellec Gwenolé 
Published: December 2021

SIGNIFICANCE
Screening for ocular anomalies using fundus photography is key to prevent vision impairment and blindness. With the growing and aging population, automated algorithms that can triage fundus photographs and provide instant referral decisions are relevant to scale-up screening and face the shortage of ophthalmic expertise.

PURPOSE
This study aimed to develop a deep learning algorithm that detects any ocular anomaly in fundus photographs and to evaluate this algorithm for “normal versus anomalous” eye examination classification in the diabetic and general populations.

METHODS
The deep learning algorithm was developed and evaluated in two populations: the diabetic and general populations. Our patient cohorts consist of 37,129 diabetic patients from the OPHDIAT diabetic retinopathy screening network in Paris, France, and 7356 general patients from the OphtaMaine private screening network, in Le Mans, France. Each data set was divided into a development subset and a test subset of more than 4000 examinations each. For ophthalmologist/algorithm comparison, a subset of 2014 examinations from the OphtaMaine test subset was labeled by a second ophthalmologist. First, the algorithm was trained on the OPHDIAT development subset. Then, it was fine-tuned on the OphtaMaine development subset.

RESULTS
On the OPHDIAT test subset, the area under the receiver operating characteristic curve for normal versus anomalous classification was 0.9592. On the OphtaMaine test subset, the area under the receiver operating characteristic curve was 0.8347 before fine-tuning and 0.9108 after fine-tuning. On the ophthalmologist/algorithm comparison subset, the second ophthalmologist achieved a specificity of 0.8648 and a sensitivity of 0.6682. For the same specificity, the fine-tuned algorithm achieved a sensitivity of 0.8248.

CONCLUSIONS
The proposed algorithm compares favorably with human performance for normal versus anomalous eye examination classification using fundus photography. Artificial intelligence, which previously targeted a few retinal pathologies, can be used to screen for ocular anomalies comprehensively.
Analysis of Optical Coherence Tomography in Acute versus Chronic Central Serous Chorioretinopathy
Authors: Li Yanzhen , Jin Pengfei , Lu Jianmin , Ma Li , Qin Xiuhong 
Published: December 2021

SIGNIFICANCE
Central serous chorioretinopathy (CSC) is a common retinal disease that causes vision loss worldwide. Studying the imaging characteristics of CSC is helpful for the differential diagnosis of diseases. This study analyzed the differences between acute and chronic CSC and provide related information.

PURPOSE
The aim of this study was to describe the optical coherence tomography features in patients with acute and chronic CSC.

METHODS
Sixty-two eyes of 56 patients with CSC were included in the study. Optical coherence tomography was performed to observe the image features. The photoreceptor outer-segment (PROS) thickness above the pigment epithelium detachment (PED) coinciding with the leakage point in fundus fluorescein angiography was measured and compared with the mean PROS thickness outside the PED in acute cases. The SPSS 23.0 software (IBM Co., Chicago, IL) was used for statistical analysis.

RESULTS
Of our 56 patients (62 eyes), 41 (73.21%) were male and 15 (26.79%) were female. There were 53 eyes (85.48%) with acute CSC and 9 eyes (14.52%) with chronic CSC. Besides other common features, the new feature of a high-reflection band in the outer nuclear layer was found to be limited to the macular detachment area. In acute cases, the mean PROS thickness above the retinal pigment epithelium layer protuberance coinciding with the leakage point was 22.7 ± 8.8 μm, which was less than the mean PROS thickness outside the PED at 64.3 ± 21.3 μm (P ≤ .001).

CONCLUSIONS
The high-reflection band in the outer nuclear layer within the serous neurosensory detachment limited to the macular area was a new finding in CSC patients. This finding can be used as an imaging feature to aid in the diagnosis of CSC.