bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transition to independence and adult care for women with Turner syndrome: Current status and priorities of 1338 women and parents
Authors: Streur Courtney S. , Floody Emilia A. , Lapham Zoe K. , Sandberg David E. 
Published: November 2021

AbstractTransitioning to adult health care and functioning is crucial for youth and young adults with special health care needs, such as those with Turner syndrome (TS). The International Turner Syndrome Consensus Group developed clinical practice guidelines to improve this transition. This study sought to evaluate how effectively they have been implemented and whether they align with the priorities of women with TS and families of girls and women with TS. A web‐based survey was offered to those affiliated with major TS support organizations, with 1338 successfully responding (n = 543 women [≥18 years]; n = 232 parents of a woman [≥18 years]; and n = 563 parents of a girl with TS [<18 years]). Findings demonstrated that while most women transitioned to adult primary care providers, follow‐up with key specialists was lacking. Women and families prioritized flexibility in appointments and designating one provider to oversee all their TS‐related care. They identified health care coverage as a barrier to receiving care. The transition process to adult care and independence commonly occurred after girls become legal adults. Together, these findings serve to inform strategies to improve the delivery of transitional care for girls and women with TS.
Total Synthesis of Isorosthin L and Isoadenolin I
Authors: Ao Junli , Sun Chao , Chen Bolin , Yu Na , Liang Guangxin 
Published: November 2021

AbstractTotal syntheses of two Isodon diterpenes, isorosthin L and isoadenolin I, are reported. The synthetic strategy features a quick assembly of two simple building blocks through a diastereoselective intermolecular aldol reaction and a subsequent radical cyclization for efficient construction of a rather complex advanced intermediate bearing a quaternary stereocenter present in all Isodon diterpenes. Oxidative cleavage of the C−C bond in the cyclopentane enabled the conversion to a lactone moiety which is desired for the construction of the molecular skeleton through reductive coupling with an aldehyde carbonyl group.
Surface performance of weft‐knitted fabric composites reinforced with polytetrafluoroethylene fibers
Authors: Dong Tingting , Zhang Yiming , Yu Mingming , Zhang Xulan , Ma Pibo 
Published: November 2021

AbstractWith excellent frictional property, fabric liners are widely employed in automotive, aerospace, and so forth. Weft‐knitted fabric composites with single‐layer and double‐layer fabric structure were prepared by utilizing polytetrafluoroethylene (PTFE), Nomex, and polyester multifilament. The weft‐knitted fabric composites are expected to combine PTFE low friction coefficient and Nomex magnificent mechanical property, which has potential in manufacturing fabric liners with low friction, easy adhesion, and high wear resistance. Ball‐on‐disc friction and wear tester, 3D digital microscopy and scanning electron microscopy were applied to test their tribological performance and surface morphology. Fiber friction coefficient was tested, the average friction coefficient, roughness and wear depth of composites were compared and discussed. Results show that PTFE‐polyester double‐layer structure performs preferable fiction coefficient and good wear resistance. The influence of yarn materials along with their combination form, fabric structure on tribological performance of composites were analyzed. In conclusion, the wear mechanism including resin, fiber, yarn fracture, loop structure damage, PTFE lubricating film formation.
A multilayer transparent wood prepared by laminating two kinds of tree species
Authors: Wang Yajing , Wu Yan , Yang Feng , Wang Jing , Zhou Jichun 
Published: November 2021

AbstractTransparent wood (TW) is a new material with a certain light transmission performance, which can be widely used as new energy‐saving material. However, the application and development of TW are limited by material and thickness. In this work, the representative species of softwood and hardwood were selected for lamination. After chemical treatment, the lignin in natural wood was removed, and then the epoxy resin with a similar refractive index to the cell wall was impregnated in vacuum. By using the viscosity of epoxy resin itself, the single‐layer materials could be effectively laminated together to prepare a new type of multilayer transparent wood (MLTW). By testing the optical properties, mechanical properties. and surface properties of MLTW materials, we found that the optical transmittance and mechanical properties can be effectively controlled and selected through the selection of materials and assembly methods. Besides, the surface properties of MLTW are mainly related to its surface material. In short, MLTW is a new composite material prepared by simple lamination at the macro level. The properties of the material can be controlled through the selection of single‐layer materials and assembly methods. Compared with the traditional TW, MLTW has better performance regulation ability.
Preparation of PVA/PAM/Ag strain sensor via compound gelation
Authors: Dong Xiaoxu , Tong Song , Dai Kun , Ren Dongdong , Wang Tiantian , Wang Yanxin , Leng Yuting , Li Qian , Wang Shiwei 
Published: November 2021

AbstractPolyvinyl alcohol (PVA) and polyacrylamide (PAM) hydrogels as well as silver particles (Ag) composites are prepared by compound gelation. The structure and properties of the composites, which are controlled by the reaction of acrylamide in the hydrogel, are analyzed and the feasibility of their application in strain sensors are explored. The effects of different PVA concentration, content, and particle size of Ag on the mechanical properties, rheological properties of the composites are studied. PVA/PAM/Ag composites are selected as the substrate of the strain sensor, when the concentration of PVA is 0.08 g/ml, the particle size of Ag is 60 nm and the addition amount is 0.15 wt%. The strain sensing performance of the composites under low strain (5%, 20%, and 50%) and high strain (100% and 200%) are tested respectively. The hydrogel composite sensor shows sensitive and stable response to human motion, and it has the ability of distinguish the movement of different human body joints.
Development and investigation of antibacterial and antioxidant characteristics of poly lactic acid films blended with neem oil and curcumin
Authors: Subbuvel Mohan , Kavan Panneerselvam 
Published: November 2021

AbstractAntibacterial films based on polylactic acid (PLA) were developed by blended with neem oil (NO) and curcumin via solvent casting technique. Nuclear magnetic resonance (NMR) results revealed the presence of fillers (NO and curcumin) in the PLA matrix. Without losing much of the PLA film's transparency, the composite film has exceptional ultra violet‐blocking properties. The addition of NO to the PLA matrix increased the elongation of the composite film by reducing tensile strength while not affect their thermal stability. The water vapor transfer rate (WVTR), water contact angle (WCA), and oxygen transmission rate (OTR) of the film were marginally improved by the introduction of NO and curcumin. The curcumin inclusion prevented the plasticized PLA/NO/curcumin compositions surfaces from porosity according to the morphology studies. Further, the PLA/NO/curcumin composites films exhibited good antibacterial, antioxidant activity and therefore have the possibility to use as an active packaging material for food preservation and safety.
Melt spinning of PLA/PCL blends modified with electron induced reactive processing
Authors: Huang Ying , Brünig Harald , Müller Michael Thomas , Wießner Sven 
Published: November 2021

AbstractThe effect of electron induced reactive processing (EIReP) on the properties of biodegradable polylactide/masticated polycaprolactone (PLA/PCL) blends was firstly investigated without introducing any chemical additives. Subsequently, the melt spinnability of EIReP modified PLA/PCL blends was explored by a piston spinning. The EIReP modified PLA/PCL blends showed improved melt strength and elastic behavior. This is due to the formation of long chain branches and the enhanced chain entanglements. The crystallinity of PLA phase increased from 2.4% to 35.7% as the applied dose increased from 0 to 50 kGy. The PLA/PCL blends treated with 12.5 kGy demonstrated 2.4‐fold of impact toughness than that of neat PLA, suggesting a superior interfacial adhesion and chain interactions between two phases. The crystallinity of the PLA/PCL fibers decreased from 33.3% to 17.8% as the applied dose increased from 12.5 kGy to 50 kGy. It is resulted from the hindered chain mobility of branched/grafted structures during fiber formation. The fracture strain of the fibers using a non‐irradiated blend was 232.9% which increased to 311.5% for the 50 kGy irradiated blends. However, the fibers spun from irradiated blends demonstrated similar initial modulus but reduced tenacity compared to fibers spun from non‐irradiated blend material.
Environmental and cost benefits of multi‐purpose buffers in an agricultural watershed for biomass production
Authors: Ha Miae , Wu May 
Published: November 2021

AbstractThe cost‐benefit of riparian buffers to landowners has not been fully understood despite its ecosystem benefits. This study investigates the environmental and economic value of multi‐purpose buffers for biomass production under alternative land‐management scenarios at the watershed scale. The work incorporates the Soil and Water Assessment Tool with a field‐scale tool, the Agriculture Conservation Practice Framework, and cost‐benefit analysis. Our work took place in the agriculturally dominant Raccoon River watershed (RRW) in Iowa. The cost analysis includes implementing and harvesting the switchgrass buffers, the value of nitrogen and phosphorus fertilizer, and the forgone income of cropland to determine the net return under 12 alternative feedstock scenarios. We estimated that 14 603 Mg of nitrogen and 2563 Mg of phosphorus runoffs can be intercepted by riparian buffers in the RRW, representing a nutrient loss reduction of 11% of nitrogen and 26% of phosphorus. These nutrients are valued at $1.31 million (M) for phosphorus and $1.24 M for nitrogen as fertilizers. The trapped nutrients account for 12% of the riparian buffers’ total cost. We found that net economic returns increase with biomass market price, increase with maintenance fertilizer application, and decrease with the cropland areas that are converted to buffers. Under current land management, a biomass market price at $60 per dry ton of biomass would be economically viable at the sub‐basin level when maintenance fertilizers are applied. At $80 per dry ton, all 108 sub‐basins in the RRW would be profitable up to $517 a year. The results highlight the trade‐offs between water quality and profitability. Published 2021. This article is a U.S. Government work and is inthe public domain in the USA. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
T‐cell surface generation of dual bivalent, bispecific T‐cell engaging, RNA duplex cross‐linked antibodies (dbBiTERs) for re‐directed tumor cell lysis
Authors: Kujawski Maciej , Li Lin , Li Harry , Yazaki Paul J. , Swiderski Piotr , Shively John E. 
Published: November 2021

AbstractBackgroundGenetic engineered Bispecific T‐cell engagers (BiTEs) generate potent cytotoxic effects.MethodsAlternately, click chemistry engineered, dual specific bivalent Bispecific T‐cell engaging antibodies (dbBiTEs) on T‐cell surfaces can be generated from parent monoclonal antibodies.ResultsWe show the formation of dbBiTEs on the surface of T‐cells along with the introduction of complementary 2′‐OMe RNA 32‐mer oligonucleotides allowing duplex formation between antibodies, designated as dbBiTERs. dbBiTERs generated in solution from anti‐CEA and anti‐CD3 OKT3 antibodies retained specific binding to CEA positive versus CEA negative cancer cells and to CD3 positive T‐cells comparable to dbBiTEs. When T‐cells were precoated with dbBiTEs or dbBiTERs and mixed with CEA positive versus CEA negative cancer cells, similar dose dependent and specific cytotoxicity were observed in redirected cell lysis assays. On‐cell generated dbBiTERs exerted potent cytotoxic responses against CEA positive targets and were localized at the cell surface by immuno‐gold EM. In addition, we demonstrate that target and T‐cells, each coated separately with complementary 2′OMe‐RNA‐linked antibodies can be cross‐linked by RNA duplex formation in vitro to generate redirected cell lysis.ConclusionThe facile generation of dbBiTERs with specific cytolytic activity from intact antibodies and their generation on‐cell offers a new avenue for antigen specific T‐cell therapy.
Graphene quantum dots‐based targeted nanoprobes detecting drug delivery, imaging, and enhanced chemotherapy of nasopharyngeal carcinoma
Authors: Yu Chaosheng , Long Zhen , Qiu Qianhui , Liu Fang , Xu Yiming , Zhang Tao , Guo Rui , Zhong Wen , Huang Shuixian , Chen Shuaijun 
Published: November 2021

AbstractOne of the main clinical treatments for advanced nasopharyngeal carcinoma is chemotherapy, but systemic administration can cause serious adverse reactions. New type of nanomaterial which can actively targeting, imaging, and treating nasopharyngeal carcinoma at the same time to enhance the effect of chemotherapy, meanwhile monitoring the intracellular drug release process at the level of single cancer cell was urgently needed. GE11, an EGFR antagonist peptide, was used to target nasopharyngeal carcinoma which has positive expression of EGFR on its nucleus. GE11‐modified graphene quantum dots (GQDs@GE11) were used as drug carriers for clinical chemotherapeutics cisplatin (CDDP) and doxorubicin (DOX). The emission spectrum of GQDs (460 nm) and the excitation spectrum of DOX (470 nm) have a good overlap, thus the transfer and release process of DOX can be sensitively detected by the fluorescence resonance energy transfer (FRET). CDDP was used to enhance the chemotherapy effect of nanoprobe, and the loading amount of DOX and CDDP on GQDs@GE11 nanoprobe were up to 67 and 50 mg/g, respectively. In vivo experiments have confirmed that GQDs@GE11/CDDP/DOX nanoprobe can be enriched to tumor site through specific targeting effect, and significantly inhibit tumor cell proliferation. This new type of targeted therapy fluorescent probe provides new ideas for the study of drug release process and the treatment of nasopharyngeal carcinoma.
Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
Authors: Cooke Ian J. , Patil Dattatraya , Bobrek Katherine , Narayan Vikram , Master Viraj , Rapaport Mark , Filson Christopher P. , Joshi Shreyas S. 
Published: November 2021

AbstractBackgroundThe presence of psychiatric disorders in patients with cancer is associated with increased morbidity and poorer outcomes. We sought to determine the impact of a new bladder cancer diagnosis on the incidence of depression and anxiety.MethodsWe used a database of billing claims (MarketScan®) to identify patients newly diagnosed with bladder cancer between 2009 and 2018. Patients with preexisting psychiatric disorders or use of anxiolytics/antidepressants were excluded. We matched cases to patients without a bladder cancer or psychiatric diagnosis. Our primary outcome was a new diagnosis of depression, anxiety, or use of anxiolytics/antidepressants. Other exposures of interest included gender and treatment received. We used multivariable regression to estimate odds ratios for these exposures.ResultsWe identified 65,846 cases with a new diagnosis of bladder cancer (31,367 privately insured; 34,479 Medicare‐eligible). Compared to controls, bladder cancer patients were more likely to develop new‐onset depression/anxiety at 6 months (privately insured: 6.9% vs. 3.4%, p < 0.001; Medicare‐eligible: 5.7% vs. 3.4%, p < 0.001) and 36 months (privately insured: 19.2% vs. 13.5%, p < 0.001; Medicare‐eligible: 19.3% vs. 16.0%, p < 0.001). Women (vs. men, privately insured: OR 1.65, 95%CI 1.53–1.78; Medicare‐eligible: OR 1.63, 95%CI 1.50–1.76) and those receiving cystectomy and chemotherapy (vs. no treatment, privately insured: OR 4.94, 95%CI 4.13–5.90; Medicare‐eligible: OR 2.35, 95%CI 1.88–2.94) were more likely to develop significant depression/anxiety.ConclusionA new diagnosis of bladder cancer was associated with increased burden of significant depression/anxiety compared with matched controls. Women and patients receiving more radical treatments had higher rates of depression and anxiety.
Primary neuroendocrine tumors of the ovary: Management and outcomes
Authors: Pang Li , Guo Zhiqiang 
Published: November 2021

AbstractBackgroundThere is currently no recognized first‐line treatment strategy for ovarian neuroendocrine tumors (NETs). Furthermore, because of the low incidence of ovarian NETs, no studies have reported prognostic statistics derived from large samples. This retrospective study aimed to investigate the clinical behavior of ovarian NETs.MethodsThe Surveillance, Epidemiology, and End Results database was used to identify women diagnosed with ovarian NETs from 2004 to 2015. Overall survival (OS), cancer‐specific survival (CSS), and independent prognostic factors for ovarian NETs were evaluated. The effects of different treatments on prognosis were also compared, as were OS and CSS rates for histological subtypes.ResultsThe 5‐year OS rates were 83.3%, 30.0%, 20.3%, and 9.8% for patients in stages I (n = 159), II (n = 23), III (n = 101), and IV (n = 148), respectively. The 5‐year CSS rates were 85.6%, 41.7%, 21.2%, and 9.8% for patients in stages I–IV, respectively. Age, American Joint Committee on Cancer (AJCC) stage, lymph node metastasis, treatment, and histological type were related to poor OS and CSS. In the early stage, the 5‐year OS and CSS rates were 97.03% and 96.90%, respectively. For patients in the advanced stage receiving comprehensive treatment (surgery + chemotherapy + radiotherapy), the 5‐year OS and CSS rates were 72.9% and 70.00%, respectively. When comparing low‐ and high‐grade neuroendocrine carcinoma, 5‐year OS rates were 93.96% and 7.01%, 5‐year CSS rates were 97.44% and 7.31%, 10‐year OS rates were 93.56% and 2.34%, and 10‐year CSS rates were 97.44% and 4.88%, respectively.ConclusionAge, AJCC stage, treatment, and histological type are independent prognostic factors of ovarian NETs. OS and CSS are relatively good for early‐stage cases treated with surgery alone, whereas more comprehensive treatment is required to improve OS and CSS in the advanced stage.
Cultural humility in psychotherapy and clinical supervision: A research review
Authors: Zhang Hansong , Watkins C. Edward , Hook Joshua N. , Hodge Adam S. , Davis Cameron W. , Norton Jolene , Wilcox Melanie M. , Davis Don E. , DeBlaere Cirleen , Owen Jesse 
Published: November 2021

AbstractCultural humility, first introduced a quarter century ago, has increasingly emerged over the last decade as a concept of considerable importance: it has been touted as playing a crucial role in potentially enhancing the relationship in both psychotherapy and supervision, its practice being heartily embraced and roundly recommended. But are those recommendations and that hearty embrace justified? What do the empirical data say? We address those questions subsequently, taking a granular look at studies in which cultural humility vis‐à‐vis psychotherapy and supervision have been examined. Based on our review of 21 psychotherapy/cultural humility studies and seven supervision/cultural humility studies, we offer critique of the research work done thus far (e.g., it being decade delimited and landlocked) and propose recommendations for future treatment and supervision investigations (e.g., internationalising cultural humility research). Because cultural humility appears to be a durable and enduring concept, appears practically beneficial for both the therapy and supervision situations and is increasingly being pursued empirically, such a research report would seem particularly timely and potentially helpful in advancing research.
Methyl and Isopropyl N‐Methylanthranilates Affect Primary Macrophage Function – An Insight into the Possible Immunomodulatory Mode of Action
Authors: Miltojević Ana B. , Mitić Katarina V. , Stojanović Nikola M. , Randjelović Pavle J. , Radulović Niko S. 
Published: November 2021

AbstractTo complement the knowledge on the anti‐inflammatory activity of methyl and isopropyl N‐methylanthranilates, two natural products with panacea‐like properties, we investigated their effects on thioglycolate‐elicited macrophages by evaluating macrophage ability to metabolize MTT, macrophage membrane function, and macrophage myeloperoxidase and phagocytic activities. Moreover, two additional aspects of the inflammatory response of these compounds, their inhibitory activity on xanthine oxidase and catalase, were studied. It was found that these two compounds regulate elicited macrophage functions, most probably by interfering with the function of cell membranes and changing the reducing cellular capacity or enzyme activity of macrophages. Nonetheless, no significant inhibitory action either towards xanthine oxidase or catalase was found, suggesting that the inhibition of these enzymes is not involved in the anti‐inflammatory mode of action of these two esters.
Outcomes during the first year following spontaneous coronary artery dissection: A systematic timeframe pooled analysis
Authors: Bocchino Pier Paolo , Franchin Luca , Angelini Filippo , D'Ascenzo Fabrizio , De Ferrari Gaetano Maria , Alfonso Fernando 
Published: November 2021

AbstractObjectivesWe aimed to compare the incidence and timing of major adverse cardiovascular events (MACE) within the first year after spontaneous coronary artery dissection (SCAD) according to the management strategy: conservative versus invasive.BackgroundTreatment of SCAD remains controversial.MethodsA pooled analysis of studies providing separate individual clinical outcomes for conservative and invasive treatment strategies within 1 year after SCAD was performed. The primary outcome measure was MACE incidence within three predefined study periods after SCAD, namely “in‐hospital”, “discharge‐to‐6‐months” and “6‐to‐12‐months”. MACE was defined as a composite of all‐cause death, myocardial infarction, target vessel revascularization, heart failure and SCAD recurrence.ResultsA total of 16 studies (444 patients) were included; 277 (62%) patients were treated conservatively and 167 (38%) invasively. Within 1‐year follow‐up, 39 (67%) MACE occurred during the in‐hospital period compared to 10 (17%) in the “discharge‐to‐6 months” period and 9 (16%) in the “6‐to‐12‐months” period (p < 0.0001 for the overall comparison). MACE incidence was also significantly different between the three study periods in the conservatively‐treated group (23 [78%] vs. 7 [23%] vs. 0 [0%], respectively; p < 0.0001) and the invasively‐treated group (12 [66%] vs. 3 [17%] vs. 3 [17%], respectively; p < 0.0001), although no significant difference was found regarding MACE incidence in the intra‐period comparisons between conservative and invasive treatment strategies.ConclusionsThis pooled analysis showed that most MACE following SCAD occurred during the in‐hospital period compared to the following two semesters, regardless of the treatment strategy. No difference regarding MACE incidence was found between conservative and invasive strategies in each study period.
Hair regrowth and maintenance in alopecia universalis patient treated with nonablative Er:YAG laser
Authors: McCarthy Madison , Day Doris , Talaber Iva 
Published: November 2021

AbstractHair regrowth with no adverse effects following nonablative 2940‐nm Er:YAG laser treatment in alopecia universalis patient resulted in high patient satisfaction and compliance. As the main challenge in alopecia universalis is maintenance of regrown hair, patient compliance associated with this treatment might represent an advantage over traditional treatment modalities.