bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection and Validation of Chemotherapy Beneficiaries among Elderly Nasopharyngeal Carcinoma (NPC) Patients Treated with Intensity-Modulated Radiation Therapy (IMRT): A Large Real-World Study
Authors: Wu Yan-Ling , Yang Kai-Bin , Huang Ying , Shi Jing-Rong , He Qing-shui , Chen Lei , Li Wen-Fei , Huang Xiao-Dan , Lin Li , Chen Yu-Pei , Mao Yan-Ping , Tang Ling-Long , Ma Jun 
Published: November 2021

Abstract
Purpose: Using real-world evidence, this study aimed to identify elderly nasopharyngeal carcinoma (NPC) patients who would benefit from chemotherapy.Methods and Materials: 1,714 elderly NPC patients between April 2007 and December 2017 were identified. Recursive partitioning analysis (RPA) was used to generate risk-stratified outcomes. Prognostic factors were performed for individual comparisons of different risk groups to assess chemotherapy benefits.Results: The median follow-up was 59.3 (0.39-170.09) months. Epstein Barr virus (EBV) DNA and T stage were included in the RPA-generated risk stratification, categorizing patients into a good-prognosis group (EBV DNA ≤ 4,000 copies/mL & T1-2), and a poor-prognosis group (EBV DNA ≤ 4,000 copies/mL & T3-4 and EBV DNA > 4,000 copies/mL & any T). Over survival (OS) was significantly higher in the good-prognosis group compared with the training set (HR = 0.309, 95% CI = 0.184-0.517; P < 0.001), and validated in the testing set (HR = 0.276, 95% CI = 0.113-0.670; P = 0.002). In the poor-prognosis group, a significantly improved OS for chemoradiotherapy (CRT) compared with RT alone was observed (HR = 0.70, 95% CI = 0.55-0.88; P = 0.003). Patients who received induction chemotherapy (IC) + concurrent chemoradiotherapy (CCRT) and CCRT had a significantly improved OS compared with RT alone (IC+CCRT vs. RT alone: P = 0.002; CCRT vs. RT alone: P = 0.008) but not in the IC+RT group (P = 0.306). The 5-year OS for CRT vs. RT-alone with ACE-27 scores of 0, 1 and 2 were 76.0% vs. 70.0% (P = 0.014), 80.5% vs. 68.2% (P = 0.150) and 58.5% vs. 62.2% (P = 0.490), respectively; for those aged 60-64, 65-70 and ≥70 years old they were 80.9% vs. 75.9% (P = 0.068), 73.3% vs. 63.4% (P = 0.270) and 64.8% vs. 67.1% (P = 0.820), respectively.Conclusions: For elderly NPC patients a simple screening cutoff for chemotherapy beneficiaries might be EBV DNA＜4000 copies/ml & T3-4 and EBV DNA ≥4000 copies/ml & any T, but not for those >70 years old and with an ACE-27 score > 1. IC+CCRT and CCRT were effective forms of chemotherapy.
Soil Restoration Practices Effects on Priming Effect Intensity and Carbon Fluxes
Authors: Issoufou Abdourhimou Amadou , Younoussa Bachirou Hamadou , Mahamane Sabiou , Soumana Idrissa , Maman Garba , Mahamane Ali 
Published: November 2021

Abstract
BackgroundThe decomposition of soil organic matter (SOM) is one of the most important processes influencing the global carbon (C) cycle, the physico-chemical characteristics of soils, the mineralization of nutrients for plant growth and soil food webs. Yet, priming effects are considered to be large enough to influence ecosystem carbon fluxes. Here we have tested the effects of soil restoration practices on priming effect and carbon fluxes.ResultOur results suggest that indirect effects are such as altered stabilization of older C associated with the increased inputs of fresh plant inputs (‘priming’) add uncertainty to the prediction of future soil C responses. Far ahead restoration influence the amount and composition of the decomposer organisms, including soil fauna, as well as the soil microbial community, by inducing up to more CO2 emission with fresh millet straw addition in fresh state than pre-decomposed one. Restoration had a very strong impact (increase by 22.7%) on basal soil organic matter mineralization but not on priming effect. The PE of non-restored site was lower than that of restored site by 14.9–22.7%; the lowest mineralization per unit carbon was recorded in the non-restored. Through the “4 per 1000” initiative, it has been very recently demonstrated that priming effect could have a noticeable impact on soil carbon sequestration. ConclusionWe have shown in our study that the degraded soil played a dominant positive role in the soil organic carbon mineralization. Our results provide solid evidence that SOC content plays a critical role in regulating apparent priming effects, with important implications for the improvement of C cycling models under global change scenarios.
End of Life Care for People with an Intellectual Disability a Qualitative Exploration of Staff Carers’ Experiences
Authors: McCarron Mary , McCallion Philip , Burke Eilish , Timmins Fiona 
Published: November 2021

Abstract
Background: Although people with intellectual disability are increasingly living longer and experiencing high levels of multiple co-morbidity, palliative care has received limited attention among this population. There is some evidence that their needs are unattended and that more could be done to improve care services.Methods: 28 carers who cared for older people with intellectual disability at end of life were interviewed. Data were analysed using thematic analysis. Results: One major theme emerged relating to the practical management s of end of life care in formal institutionalised settings. Seven subthemes also emerged: pain, learned acceptance, transitions, decisions, conversations about dying, GP care, rapid decline and challenges with interventions.Conclusion: Gaps emerged in the care of the person with intellectual disability. Pain assessment and pain management are particular challenges. End of life care was not always effectively planned, and earlier intervention, including end of life conversations are needed. More needs to be done in terms of education for carers, health care workers, and especially those in the acute care setting and palliative care services who may be unfamiliar with the needs of this cohort.
Upcycling Compact Discs for Bioelectronic Applications
Authors: Brown Matthew , Somma Louis , Mendoza Melissa , Noh Yeonsik , Mahler Gretchen , Koh Ahyeon 
Published: November 2021

Abstract
Electronic waste (e-waste) is a global issue brought about by the short lifespan of electronics. Viable methods to relieve the inundated disposal system by repurposing the enormous amount of e-waste remain elusive. Inspired by the need for sustainable solutions, this study resulted in a multifaceted approach to upcycling compact discs (CDs). The once-ubiquitous plates can be transformed into stretchable and flexible biosensors. Our experiments and advanced prototypes show that effective, innovative biosensors can be developed at a low-cost. An affordable craft-based mechanical cutter allows pre-determined patterns to be scored on the recycled metal, an essential first step for producing stretchable, wearable electronics. The active metal harvested from the CDs was inert, cytocompatible, and capable of vital biopotential measurements. Additional studies examined the material’s resistive emittance, temperature sensing, real-time metabolite monitoring performance, and moisture-triggered transience. This sustainable approach for upcycling e-waste provides an advantageous research-based waste stream that does not require cutting-edge microfabrication facilities, expensive materials, and high-caliber engineering skills.
Molecular Insights Into the Interaction of HPV-16 E6 Variants Against MAGI-1 PDZ1 Domain
Authors: Araujo-Arcos Lilian Esmeralda , Montaño Sarita , Bello-Rios Ciresthel , Garibay-Cerdenares Olga Lilia , Leyva-Vázquez Marco Antonio , Illades-Aguiar Berenice 
Published: November 2021

Abstract
Oncogenic protein E6 from Human Papilloma Virus 16 (HPV-16) mediates the degradation of Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI-1), throughout the interaction of its protein binding motif (PBM) with the Discs-large homologous regions 1 (PDZ1) domain of MAG1-1. Generic variation in the E6 gene that translates to changes in the protein’s amino acidic sequence modifies the interaction of E6 with the cellular protein MAGI-1. MAGI-1 is a scaffolding protein found at tight junctions of epithelial cells, where it interacts with a variety of proteins regulating signaling pathways. MAGI-1 is a multidomain protein containing two WW (rsp-domain-9), one guanylate kinase-like, and six PDZ domains. PDZ domains played an important role in the function of MAGI-1 and served as targets for several viral proteins including the HPV-16 E6. The aim of this work was to evaluate, with an in silico approach, employing molecular dynamics simulation and protein-protein docking, the interaction of the intragenic variants E-G350 (L83V), E-C188/G350 (E29Q/L83V), E-A176/G350 (D25N/L83V), E6-AAa (Q14H/H78Y/83V) y E6-AAc (Q14H/I27RH78Y/L83V) and E6-reference of HPV-16 with MAGI-1. We found that variants E-G350, E-C188/G350, E-A176/G350, AAa and AAc increase their affinity to our two models of MAGI-1 compared to E6-reference.
Synthesis, Crystal Structure, Thermal, Magnetic Properties and DFT Computations of a Ytterbium(III) Complex Derived from Pyridine-2,6-Dicarboxylic Acid
Authors: Sharif Shahzad , Saeed Maham , Dege Necmi , Bano Rehana , Gilani Mazhar Amjad , Sahin Onur , Ahmad Saeed , Ch Ayoub Rashid 
Published: November 2021

Abstract
A new ytterbium(III) complex, (DMAH2)3[Yb(Pydc)3].4H2O (1) {Pydc = Pyridine-2,6-dicarboxylate anion, DMAH = Dimethylamine} has been prepared under mild solvothermal conditions and characterized by elemental analysis, IR spectroscopy, thermal analysis and single crystal X-ray diffraction. The DMAH molecules in 1, generated in situ from hydrolysis of N,N-dimethylformamide are responsible to assemble 2D coordination polymers through N-H∙∙∙O and O-H∙∙∙O hydrogen bonding. Magnetic susceptibility measurements indicate that the complex (1) obeys the Curie Weiss law and the overall magnetic behavior is typical for the presence of weak antiferromagnetic exchange coupling interactions. Theoretical data for geometrical parameters of complex 1 agree well with the experimental data. Large HOMO-LUMO energy gap of 4.33 eV has provided kinetic stability to the complex 1. NBO analysis reflects that intramolecular charge transfer occurred between ligand and metal orbitals with the highest stabilization energy of 1024.04 kcal/mol. The negative electrostatic potential at the nitrogen and dianionic pyridine-2,6-dicarboxylate regions confirms that these are dynamic locations for Yb(III) binding.
Evaluation of Mutagenesis, Necrosis and Apoptosis induced by Omeprazole in Stomach Cells of Patients with Gastritis
Authors: Mata Ana Maria Oliveira Ferreira da , Paz Marcia Fernanda Correia Jardim , de Menezes Ag-Anne Pereira Melo , Reis Antonielly Campinho dos , Souza Bruna da Silva , Sousa Carlos Dimas de Carvalho , Machado Sônia Alves , Medeiros Thiago Soares Gondim , Sarkar Chhandan , Islam Muhammad Torequl , Sharifi-Rad Javad , Daştan Sevgi Durna , Alshehri Mohammed M M , Sousa João Marcelo de Castro e , Cavalcante Ana Amélia de Carvalho Melo 
Published: November 2021

Abstract
Background: Gastritis is a superficial and prevalent inflammatory lesion that is considered a public health concernoncecause gastric ulcers and gastric cancer, especially due to Helicobacter pylori infection. Proton pump inhibitors, such as omeprazole, are the most widely used drugs in order to treat this illness. The aim of the study was evaluating the cytogenetic effects of omeprazole in stomach epithelial cells of patients with gastritis in presence and absence of H. pylori, using to this the application of cytogenetic biomarkers and measurements of catalse and superoxide dismutase. Methods: The study included 152 patients from the Gastroenterology Outpatient Clinic of Hospital Getúlio Vargas, Teresina - PI, that reported the continuous and prolonged use of omeprazole in doses of 20, 30 and 40 mg/kg. The participants were divided into groups: (1) patients without gastritis (n = 32); (2) patients without gastritis but with use of OME (n = 24); (3) patients with gastritis (n = 26); (4) patients with gastritis undergoing OME therapy (n = 26); (5) patients with gastritis and H. pylori (n = 22) and (6) patients with gastritis and H. pylori on OME therapy (n = 22). Results: OME induces cytogenetic risks in the epithelium of the stomach due to the formation of micronuclei (group 6> 1,2,3,4,5; group 5> 1,2,3; group 4> 1,2,3); bridges (groups 4 and 6> 1,2,3,5 and group 2> 3,5); buds (groups 2,4,6>, 1,3,5); binucleated cells (group 6> 1,2,3,4,5; group 4> 1,2,3); groups 2 and 3> 1); picnoses (group 6> 1,2,3,4,5), groups 2 and 5> 1,3; group 4> 1,2,3,5); cariorrexis (groups 6 and 4> 1,2,3,5; groups 2,3,5> 1) and karyolysis (groups 2,4, and 6> 1,3,5; groups 3 and 5> 1). These data show that omeprazole induces cytogenetic risks, especially due to infection with H. pylori, thus indicating the clastogenic and/or aneugenic effects, chromosomes changing, gene expression, cytotoxicity and apoptosis. Conclusions: These risks can be attributed to several mechanisms that are still unclear, including oxidative damage, as observed by increases in catalase and superoxide dismutase. Positive correlations between these antioxidant enzymes were obtained with the formation of micronuclei, and negative for picnoses. Thus, the continuous and prolonged use of omeprazole induces genetic instability, which can be monitored, in cytogenetic analyzes, as anticipation for cancer, especially gastric.
The Use of Cell Salvage During Second-stage Reimplantation for the Treatment of Chronic Hip Periprosthetic Joint Infection: a Retrospective Cohort Study
Authors: Liu Zunhan , Yang Xuetao , Zhao En-Ze , Wan Xufeng , Cao Guorui , Zhou Zongke 
Published: November 2021

Abstract
Introduction Given the possibility of undetectable infection, the use of cell salvage is relatively contraindicated in cases of reimplantation for chronic hip periprosthetic joint infection (PJI). However, there is no published data supporting this assertion. The purpose of the current study was to compare the reinfection rate and rate of in second-stage reimplantation for PJI with or without intraoperative cell salvage reinfusion.Materials and methods We identified 125 patients who underwent two-stage exchange for chronic hip PJI between November 2012 and April 2019. The groups of patients who had and had not received intraoperative cell salvage reinfusion were compared with respect to the curative infection-free rate and need for postoperative ABT. We identified independent factors associated with ABT using multiple regression analysis.Results The log-rank survival curve with an endpoint of infection eradication failure was not significantly different between the cell salvage group (98.4%, 95% CI 95.3-99.9%) and the control group (95.3%, 95% CI 90.2-99.9%) at one year (log rank, P = .330). Meanwhile, the rates of postoperative ABT in the cell salvage group were significantly lower than those in the control group (11.5% vs 26.6%, P = .041). In multivariable models, patient age, body mass index (BMI), preoperative haemoglobin level, and intraoperative cell salvage were independent predictors of ABT exposure (P < .05).Conclusions The use of cell salvage during reimplantation in two-stage exchange for chronic hip PJI did not appear to increase the reinfection rate, while it significantly reduced the rate of postoperative allogeneic red blood transfusion. Greater age, lower BMI, lower preoperative haemoglobin, and non-intraoperative cell salvage reinfusion were associated with higher rate of allogeneic red blood transfusion.
Analysis and Test of Conductive Shaft of Large Horizontal NC ECM Machine Tool
Authors: Tang Lin , Zheng Yaze , Shi Chengjin , Zhang Lifeng , Wang Zhao 
Published: November 2021

Abstract
In order to solve the problems of serious heating and easy ablation of conductive shaft in electrochemical machining of special-shaped deep hole with large aspect ratio, the two schemes of single side copper bar and symmetrical copper bar of conductive shaft were studied by ANSYS software. And the conductive shaft scheme based on symmetrical copper bar scheme was determined. The thermoelectric coupling model of the conductive shaft was established to analyze the distribution law of temperature field and thermal deformation of conductive shaft under different working conditions. Through the machining test of special-shaped inner spiral deep hole parts with large aspect ratio, the results show that under the conditions of working current of 15 000 A, feed rate of 5 mm/min and continuous machining for 14 hours, the forming accuracy of the workpiece is ±0.15 mm and the surface roughness is better than Ra0.8 µm. The performance of the conductive shaft is stable and meets the actual processing requirements. The heat dissipation performance of the conductive shaft can be optimized by providing air flow on the upper surface and side at the same time.
Assessment of The Burden of, and Women’s Experience With Screening For, Maternal Perinatal Depression in Kuwait
Authors: Alenezi Rand , Alduosari Madhawi , Alotaibi Aseel M. , Alrasheedi Danah , Alenezi Lolwah , Naser Danah , Alshammari Albatool T. , Alrasman Sarah , Aldein Lulwa J. , Almarabheh Amer J. , Ahmed Jamil 
Published: November 2021

Abstract
Background

Perinatal depression can have a devastating impact upon the health and lives of the mothers and their children. Although guidelines are in place to properly screen women for perinatal depression in high income countries, there still is a possibility that some women may be missed. Identifying women with or at high risk of perinatal depression is even more important during COVID-19 pandemic. This study was aimed to measure prevalence and associated factors of perinatal depression, and to understand the women’s experience of screening for perinatal depression in Kuwait.
Methods

Women who​ ​had recently attended antenatal and postnatal clinics in Kuwait during COVID-19 pandemic were approached through snowball sampling with the help of physicians in Kuwait in a cross-sectional online survey. They answered an online self-administered questionnaire consisting of Edinburgh postnatal depression scale, sociodemographic characteristics, and items about their experience of screening during antenatal and postnatal checkup. Out of the 158 women who answered this questionnaire, 75.3% were in their third trimester of pregnancy and the rest were in the postpartum period.
Results

Perinatal depression was possible in 31 (19.6%) highly possible in 23 (14.6%), and probable in 52 (32.9%) women in our study, indicating an alarming prevalence of the condition in the sampled population. A large proportion of the sample (66.5%) said that they were not aware of a screening process for perinatal depression, whereas only 5.7% said that they were screened for it. In the sample, 65.1% who were not screened for perinatal depression had perinatal depression (P<0.05). The mean scores for variables representing family support and help were higher among the normal women than with perinatal depression (P<0.001). Similarly, women with perinatal depression had scores towards disagreement when they were asked if they could easily talk about their problems and thoughts with their friends (P<0.01).
Conclusions

Maternal perinatal depression was high in Kuwaiti women who were either in their third trimester or had just given birth to a baby. The lack of awareness about the screening process and extremely low levels of screening for perinatal depression indicates the need to improve these women’s access to adequate screening services during and after pregnancy.
Invasive Pulmonary Aspergillosis Due to Aspergillus Lentulus in a Liver Transplant Recipient: a Case Report and Literature Review
Authors: Sun Yao , Zhang Yuyi , Xu Jing , Wang Ting , Shi Xiaoping 
Published: November 2021

Abstract
Background: Aspergillus lentulus, a new species discovered in 2005, is a rare fungal pathogen with reduced sensitivity to antifungal agents. Case presentation: Here we reported a 58-year-old male who underwent a liver transplantation on January 2020 and followed by maintenance immunosuppressive therapy. Then A.lentulus was cultured from his sputum twice and identified by using the MALDI-TOF-MS and confirmed by the reference of RUO database. In the susceptibility tests of the isolate, minimal inhibitory concentrations for amphotericin B, voriconazole, posaconazole, and caspofungin were found to be 0.5 mg/L, 1.0 mg/L, 0.5 mg/L and 8 mg/L, respectively. The patient was improved after treatment with a voriconazole 0.2g q12h orally plus caspofungin 50mg qd intravenously. Conclusion: A. lentulus is easily confused with A. fumigatus and its susceptibility to amphotericin B and azoles antifungal agents is reduced. Therefore, the identification of strain and drug susceptibility test are very important for clinical treatment.
NOMA Resource Allocation Method in IoV Based on Prioritized DQN-DDPG Network
Authors: He Mengli , Li Yue , Wang Xiaofei , Liu Zelong 
Published: November 2021

Abstract
To meet the demands of massive connections in the Internet-of-vehicle (IoV) communications, non-orthogonal multiple access (NOMA) is utilized in the local wireless networks. In NOMA technique, power multiplexing and successive interference cancellation techniques are utilized at the transmitter and the receiver respectively to increase system capacity, and user grouping and power allocation are two key issues to ensure the performance enhancement. Various optimization methods have been proposed to provide optimal resource allocation, but they are limited by computational complexity. Recently, the deep reinforcement learning (DRL) network is utilized to solve the resource allocation problem. In a DRL network, an experience replay algorithm is used to reduce the correlation between samples. However, the uniform sampling ignores the importance of sample. Different from conventional methods, this paper proposes a joint prioritized DQN user grouping and DDPG power allocation algorithm to maximize the sum rate of the NOMA system. At the user grouping stage, a prioritized sampling method based on TD-error (temporal-difference error) is proposed to solve the problem of random sampling, where TD-error is used to represent the priority of sample, and the DQN takes samples according to their priorities. In addition, sum tree is used to store the priority to speed up the searching process. At the power allocation stage, to deal with the problem that DQN cannot process continuous tasks and needs to quantify power into discrete form, a DDPG network is utilized to complete power allocation tasks for each user. Simulation results show that the proposed algorithm with prioritized sampling can increase the learning rate and perform a more stable training process. Compared with the previous DQN algorithm, the proposed method improves the sum rate of the system by 2% and reaches 94% and 93% of the exhaustive search algorithm and optimal iterative power optimization algorithm, respectively. While the computational complexity is reduced by 43% and 64% compared with the exhaustive search algorithm and optimal iterative power optimization algorithm, respectively.