bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic performance of agritourism: an analysis of farms located in a less favoured area in Italy
Authors: Arru Brunella , Furesi Roberto , Madau Fabio A. , Pulina Pietro 
Published: July 2021

AbstractFarms that operate in less favoured areas (LFAs) often suffer in achieving adequate profits. Diversification strategies, such as direct selling and offering recreational services, can play an important role in integrating earning sources and, as a consequence, increasing farm profitability. Such opportunities would depend on the efficient distribution and use of farm resources among different activities as well as the added value creation of farm output. However, achieving positive results is not obvious in LFAs due to different types of inherent constraints (geographical, social, economic). The paper aims to evaluate the role of agritourism in affecting the economic performance of multifunctional farms located in a less favoured area of Sardinia (Italy). To be more precise, using so-called working farm income as the main indicator resulting from balance sheet analysis, production factor rewards are determined for 15 agritourism farms. The results show controversial performance but basically highlight the difficulty agritourist farmers have both remunerating their work at market price levels and being profitable. This research contributes to the debate on LFAs and offers useful reflections for policy-makers and practitioners about the potential and critical aspects of agritourism in LFAs.
Nowcasting earthquakes in Sulawesi Island, Indonesia
Authors: Pasari Sumanta , Simanjuntak Andrean V. H. , Neha  , Sharma Yogendra 
Published: July 2021

AbstractLarge devastating events such as earthquakes often display frequency–magnitude statistics that exhibit power-law distribution. In this study, we implement a recently developed method called earthquake nowcasting (Rundle et al. in Earth Space Sci 3: 480–486, 2016) to evaluate the current state of earthquake hazards in the seismic prone Sulawesi province, Indonesia. The nowcasting technique considers statistical behavior of small event counts between successive large earthquakes, known as natural times, to infer the seismic progression of large earthquake cycles in a defined region. To develop natural-time statistics in the Sulawesi Island, we employ four probability models, namely exponential, exponentiated exponential, gamma, and Weibull distribution. Statistical inference of natural times reveals that (i) exponential distribution has the best representation to the observed data; (ii) estimated nowcast scores (%) corresponding to M ≥ 6.5 events for 21 cities are Bau-bau (41), Bitung (70), Bone (44), Buton (39), Donggala (63), Gorontalo (49), Kendari (27), Kolaka (30), Luwuk (56), Makassar (52), Mamuju (58), Manado (70), Morowali (37), Palopo (34), Palu (62), Pare-pare (82), Polewali (61), Poso (42), Taliabu (55), Toli-toli (58), and Watampone (55); and (iii) the results are broadly stable against the changes of magnitude threshold and area of local regions. The presently revealed stationary Poissonian nature of the underlying natural-time statistics in Sulawesi brings out a key conclusion that the seismic risk is the same for all city regions despite their different levels of cycle progression realized through nowcast scores. In addition, though the earthquake potential scores of the city regions will be updated with the occurrence of each small earthquake in the respective region, the seismic risk remains the same throughout the Sulawesi Island.
Bone remodeling around implants placed after socket preservation: a 10-year retrospective radiological study
Authors: Roberto Crespi , Paolo Toti , Giovanni Crespi , Ugo Covani , Bruno Brevi , Giovanni-Battista Menchini-Fabris 
Published: July 2021

Abstract
Background
To evaluate and compare the long-term clinical and radiological outcomes of post-extraction sockets after ridge preservation either with porcine xenograft or collagen alone. Patients underwent single-tooth extraction in the posterior mandible. Fresh extraction sockets were filled with pre-hydrated cortico-cancellous porcine bone or collagen sponge. Two or 3 months later, a ridge expansion technique with immediate implant positioning placement was performed. Primary (alveolar width changes) and secondary outcomes (adverse events and long-term maintenance of buccal plate covering the implant) were evaluated.

Results
Thirty-four women and 20 men were selected: 30 implants (group A) placed into healed post-extraction sockets grafted with porcine bone and 24 (group B) into sockets filled with a collagen sponge. There was a significant loss in width in both groups from the first and second surgery (ranging between 2.7 mm and 4.5 mm). The ridge splitting with bone expansion resulted in significant long-term increases in width for both procedures and implant sites. Non-significant differences in alveolar width were registered between the groups at 10-year follow-up even if the analysis of the implant buccal bone coverage suggested that group A had significantly worst results.

Conclusions
Porcine bone group had significantly better short-term outcomes with lower long-term maintenance of the buccal plate.
Traumatic brain injury and sight loss in military and veteran populations– a review
Authors: Hussain Syeda F. , Raza Zara , Cash Andrew T. G. , Zampieri Thomas , Mazzoli Robert A. , Kardon Randy H. , Gomes Renata S. M. 
Published: July 2021

AbstractWar and combat exposure pose great risks to the vision system. More recently, vision related deficiencies and impairments have become common with the increased use of powerful explosive devices and the subsequent rise in incidence of traumatic brain injury (TBI). Studies have looked at the effects of injury severity, aetiology of injury and the stage at which visual problems become apparent. There was little discrepancy found between the frequencies or types of visual dysfunctions across blast and non-blast related groups, however complete sight loss appeared to occur only in those who had a blast-related injury. Generally, the more severe the injury, the greater the likelihood of specific visual disturbances occurring, and a study found total sight loss to only occur in cases with greater severity. Diagnosis of mild TBI (mTBI) is challenging. Being able to identify a potential TBI via visual symptoms may offer a new avenue for diagnosis.
Recent advances in transdermal drug delivery systems: a review
Authors: Jeong Woo Yeup , Kwon Mina , Choi Hye Eun , Kim Ki Su 
Published: July 2021

Abstract
Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and persistence among patients. TDDS could be applicable in not only pharmaceuticals but also in the skin care industry, including cosmetics. Because this method mainly involves local administration, it can prevent local buildup in drug concentration and nonspecific delivery to tissues not targeted by the drug. However, the physicochemical properties of the skin translate to multiple obstacles and restrictions in transdermal delivery, with numerous investigations conducted to overcome these bottlenecks. In this review, we describe the different types of available TDDS methods, along with a critical discussion of the specific advantages and disadvantages, characterization methods, and potential of each method. Progress in research on these alternative methods has established the high efficiency inherent to TDDS, which is expected to find applications in a wide range of fields.
Role of slaughter facilities management in zoonoses and safety of meat produced for human consumption in Nigeria: a review
Authors: Ibrahim Salisu , Kaltungo Bilkisu Yunusa , Uwale Hajara Buhari , Baba Alhassan Yunusa , Saidu Shehu Na-Allah , Mohammed Farouk Umar , Dahiru Hashimu Mohammed 
Published: July 2021

AbstractBackgroundThis study attempts to review the role of slaughter facilities management of all zoonotic diseases encountered at the abattoirs as well as the safety of meat produced for public consumption in abattoirs in Nigeria. Good hygienic practices were totally absent in the abattoirs. There were dilapidated slaughtering and processing facilities, inadequate clean water supplies, no refrigerators and lack of facilities for the collection and storage of waste. Zoonotic agents demonstrated in slaughtered animals in Nigeria includeMycobacterium tuberculosis,Mycobacterium bovis,Leptospiraspecies,Campylobacterspecies,Yersiniaspecies,Clostridiaspecies.,Brucella abortus, Brucella melitensis, Brucella suis, andSalmonella spp. Other disease-causing infectious agents encountered at the abattoirs includeEcherichia coliO157,SalmonellaandCampylobacterspecies. The meat transportation is done by motor bike, wheel barrows and open vehicles and this become sources of physical contamination.Main BodyAnimals were not being examined regularly before or after slaughter, offals were washed with drainage water, effluent from drainage systems and that meat and organs cleaned from such drainages were sold to the public, leading to unsafe meat being released for public consumption. Meat and carcasses were conveyed out of the abattoir using unhygienic means of transport. Butchers and many abattoir workers were observed not using protective clothing during operations. Waste disposal was indiscriminate not regularly carried out which was hazardous to the environment, while the authorities concerned were not making any effort to improve the situation. Diseases such as Contagious Bovine Pleuropneumonia, Fasciolosis, Tuberculosis and Helminthoses were most frequently encountered some of the diseases were of public health and economic importance.ConclusionMeat Inspection and hygiene Act shall be enacted and signed into law. Provision of waste disposal system such as incinerators are recommended. The drainage system should be upgraded and modernized. Use of abattoir waste as a manure and the slurry as fertilizer is also recommended. In Nigeria none of the abattoirs met the minimum hygienic standard of operation as recommended by the Codex Alimentarius and they could not have supported the production of safe meat and meat products for human consumption.
Recent progress in electro-optic polymer for ultra-fast communication
Authors: Ullah Fateh , Deng Niping , Qiu Feng 
Published: July 2021

AbstractThe rocketed development concerning electro-optic polymers fundamentally motivated by its pragmatic application in envisioning second-order nonlinear optics and waveguiding are cardinal. Modern synthetic strategies consigned an outstanding optical quality amorphous polymers with enhanced properties. Documented data revealed a huge progress in understanding their implementation, however challenges still exist regarding their temporal stabilities etc. This review delivers a brief investigation of nonlinear optical (NLO) polymer materials demonstrated over previous decades. Besides, their categorical explanation along with their structural architecting via engineering polymeric backbone or functionalization of the molecular entities have been reviewed. Correspondingly, their temporal and thermal stabilities accompanied by NLO characteristics features are also discussed.
Bioequivalence study of different brands of vildagliptin in healthy human subjects
Authors: Sharma Mahaveer , Agrawal S. S. 
Published: July 2021

Abstract
Background
Vildagliptin is a dipeptidyl peptidase-4 inhibitor used to treat diabetes mellitus. No bioequivalence study data have been published for the Indian population comparing bioequivalence of vildagliptin brands Galvus, Zomelis, and Jalra. This study aimed to evaluate the bioequivalence between three brands of vildagliptin 50 mg tablet (test 1, Zomelis; test 2, Jalra; and reference, Galvus) and to compare these test formulations with the reference formulation to meet the regulatory requirements of bioequivalence of CDSCO, India. The study was conducted in the clinical research center of the college after enrolling 12 healthy volunteers. This study was a single-dose, randomized, open-label, balanced, three treatment, three period, under fasting condition in 12 adult healthy volunteers. After overnight fasting, the subjects received a single dose of either of any three brands of the vildagliptin tablet (T1—test 1; T2—test 2; and R—reference). The washout period was 7 days. Randomization was in the way of T1T2R in the first period, T2T1R in the second period, and RT1T2 in the third period. Blood samples were collected, after that drug concentration in the plasma was measured with the help of HPLC. Outcome measures 90% confidence interval of the geometric mean ratios (test/reference) for the LnCmax, LnAUC0-t, and LnAUC0-∞ was calculated.

Results
The AUC0-t was 1390.03, 1401.50, and 1409.37 ng h/ml for the T1, T2, and R, respectively. Cmax was 287.89, 287.41, and 285.17 ng/ml for the T1, T2, and R, respectively. AUC0-∞ was 1452.03, 1467.59, and 1473.53 ng h/ml for the T1, T2, and R, respectively. No significant difference was observed in the pharmacokinetic parameters between the T1, T2, and R. The geometric mean ratios for T1/R for LnCmax, LnAUC0-t, and LnAUC0-∞ were 1.0014 (90% CI, 1.0002–1.0026), 0.9992 (90% CI, 0.9971–1.0013), and 0.9994 (90% CI, 0.9973–1.0016), respectively. For the T2/R, geometric mean ratios for LnCmax, LnAUC0-t, and LnAUC0-∞ were 1.0003 (90% CI, 0.9992–1.0013), 0.9988 (90% CI, 0.9969–1.0008), and 0.9985 (90% CI, 0.9961–1.0010), respectively.

Conclusion
In this single-dose study involving Indian healthy volunteers under fasting conditions, the three brands of vildagliptin (Zomelis, Jalra, and Galvus) were bioequivalent as per the bioequivalence criterion of CDSCO, India.
Short-term seasonal changes of the Dzita beach of Ghana using geographic information system and photogrammetry
Authors: Brempong Emmanuel K. , Angnuureng Donatus Bapentire , Appeaning Addo Kwasi , Jayson-Quashigah Philip-Neri 
Published: July 2021

Coastal erosion has become an issue globally. As the sea level continues to rise due to global warming, projections are that erosion would increase. To address the issue sustainably, relevant scientific information such as sediment transport and shoreline dynamics is required at local scales. Over the years, erosion at the eastern coast of Ghana has been mainly evaluated using low-resolution imagery due to the challenges in retrieving high-resolution data in the nearshore region. An unmanned aerial vehicle (UAV) approach was used to assess beach evolution on a seasonal and short-term basis between May 2018 and December 2019. Using the UAV approach, shoreline changes, sediment volume changes, and profile elevation parameters were extracted for the Dzita beach of Ghana. Shoreline changes indicated the dominance of erosion during the first and third phases (May 2018–December 2018 and June 2019–December 2019, respectively) at a rate of −7.23 ± 0.23 and −4.85 ± 0.23 m/yr, whereas the second phase (January 2019–June 2019) showed accretion of +8.44 ± 0.23 m/yr. Beach profiles from the first, second, and third phases had steep and gentle slopes, respectively. From these observations, it was recommended that soft engineering approaches such as beach nourishment should be implemented to protect the shoreline and strict prevention of nearshore sand mining and gravel mining. It is also possible that the beach could go through a cycle of changes. Further studies using this same approach should be done as well as probing into other parameters such as nearshore bathymetry to have a better understanding of beach dynamics as envisaged.
Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis
Authors: Salazar de Pablo Gonzalo , Davies Cathy , de Diego Héctor , Solmi Marco , Shin Jae Il , Carvalho Andre F. , Radua Joaquim , Fusar-Poli Paolo 
Published: July 2021

Abstract

Background
Individuals at clinical high risk of psychosis (CHR-P) recruited in randomized clinical trials (RCTs) and observational cohorts may display a different enrichment and hence risk of transition to psychosis. No meta-analysis has ever addressed this issue.

Methods
“Preferred Reporting Items for Systematic reviews and Meta-Analyses” (PRISMA) and “Meta-analysis Of Observational Studies in Epidemiology” (MOOSE)–compliant meta-analysis. PubMed and Web of Science were searched until November 2020 (PROSPERO:CRD42021229223). We included nonoverlapping longitudinal studies (RCTs-control condition and observational cohorts) reporting the transition to psychosis in CHR-P individuals. The primary effect size measure was the cumulative risk of transition at 0.5, 1, and 2 years follow-up in RCTs compared to observational cohorts. Random effects meta-analyses, heterogeneity assessment, quality assessment, and meta-regressions were conducted.

Results
Ninety-four independent studies (24 RCTs, 70 observational cohorts) and 9,243 individuals (mean age = 20.1 ± 3.0 years; 43.7% females) were included. The meta-analytical risk of transitioning to psychosis from a CHR-P stage was 0.091 (95% confidence intervals [CI] = 0.068–0.121) at 0.5 years, 0.140 (95% CI = 0.101–0.191) at 1 year and 0.165 (95% CI = 0.097–0.267) at 2 years follow-up in RCTs, and 0.081 (95% CI = 0.067–0.099) at 0.5 years, 0.138 (95% CI = 0.114–0.167) at 1 year, and 0.174 (95% CI = 0.156–0.193) at 2 years follow-up in observational cohorts. There were no between-group differences in transition risks (p > 0.05). The proportion of CHR-P individuals with substance use disorders (excluding alcohol and cannabis) was higher in observational cohorts (16.8, 95% CI = 13.3–21.0%) than in RCTs (3.4, 95% CI = 0.8–12.7%; p = 0.018).

Conclusions
There is no meta-analytic evidence supporting sampling biases in RCTs of CHR-P individuals. Further RCTs are needed to detect effective interventions to prevent psychosis in this at-risk group.
FGFR Inhibitor Toxicity and Efficacy in Cholangiocarcinoma: Multicenter Single-Institution Cohort Experience
Authors: Gile Jennifer J. , Ou Fang-Shu , Mahipal Amit , Larson Joseph J. , Mody Kabir , Jin Zhaohui , Hubbard Joleen , Halfdanarson Thorvardur , Alberts Steven R. , Jatoi Aminah , McWilliams Robert R. , Ma Wen Wee , Ilyas Sumera , Smoot Rory , Roberts Lewis , Gores Gregory , Borad Mitesh , Bekaii-Saab Tanios S. , Tran Nguyen H. 
Published: July 2021

PURPOSECholangiocarcinomas (CCA) are a group of heterogeneous tumors arising from the biliary epithelia. Significant sequencing efforts have provided further insights into the molecular mechanisms of this disease including fibroblast growth factor receptor ( FGFR) alterations, which occurs in approximately 15%-20% of intrahepatic CCAs. Herein, we describe the FGFR inhibitor (FGFRi)-associated treatment toxicity and cancer-specific outcomes from a multicenter single-institution cohort.METHODSThis is a retrospective study of patients with CCA and known FGFR alterations treated with FGFRi. We describe the toxicity and efficacy in patients treated at Mayo Clinic between January 2010 and December 2020.RESULTSOur group identified 61 patients with advanced or metastatic CCA, 19 males (31%) and 42 females (69%), harboring FGFR alterations who received FGFRi. The most common grade 1 or higher adverse events for all patients included fatigue (92%), AST elevations (78%), anemia (80%), decreased platelet count (63%), and hyperphosphatemia (74%). Median progression-free survival on FGFRi was 5.8 months for all patients (95% CI, 4.9 to 9.0). Females had significantly longer progression-free survival at 6.9 months (95% CI, 5.2 to 11.8) on FGFRi compared with males at 4.9 months (95% CI, 2.8 to not estimable; P = .038).CONCLUSIONFGFRi are well tolerated with clinical efficacy. With the recent approval of FGFRi by the US Food and Drug Administration and ongoing clinical trials for new FGFRi, understanding outcomes and toxicity associated with these medications is important for precision oncology.
Limit on Higgs boson trilinear self-coupling in coupled technicolor models
Authors: Doff A. , Natale A. A. 
Published: July 2021

Abstract
The trilinear self-coupling of the Higgs boson, in a theory in which this boson is composite, is compared to the experimental bound of this quantity obtained by the CMS experiment. In the case of a model where technicolor (TC) is coupled to QCD, we find that the experimental result already constrains the dynamics of the theory, which is represented by an expression of the technifermion self-energy

typical of technicolor coupled models, and function of the dynamically generated technifermion mass and two other parameters that describe the technifermion dynamical mass momentum dependence. The limits imposed on this dynamics allow us to make a simple determination of pseudo-Goldstone boson masses that appear in these theories, indicating that these bosons may be expected to be quite massive.
Regulating Bracero Migration: How National, Regional, and Local Political Considerations Shaped the Bracero Program
Authors: García Alberto 
Published: July 2021

AbstractThis article examines how federal, state, and municipal governments administered the migrant worker selection process in the states of Guanajuato, Jalisco, and Michoacán during the initial phase of the Bracero Program, a bilateral initiative that allowed Mexican men to work in the United States as seasonal contract farmworkers. It argues that multiple political factors—such as the activities of groups that opposed the ruling Partido Revolucionario Institucional, organized labor conflicts, and the need to respond to natural disasters—influenced how officials allocated contracts, which rural workers were deemed eligible or ineligible to migrate, and which individual rural workers ultimately received contracts. The article shows that federal authorities delegated increased administrative responsibilities to state and municipal governments as the Bracero Program progressed, which in turn allowed regional and local officials to exercise considerable influence during selection periods.
Mechanics of the Peripheral Auditory System: Foundations for Embodied Listening Using Dynamic Systems Theory and the Coupling Devices as a Metaphor
Authors: Jactat Bruno 
Published: July 2021

Current approaches to listening are built on standard cognitive science, which considers the brain as the locus of all cognitive activity. This work aims to investigate listening as phenomena occurring within a brain, a body (embodiment), and an environment (situatedness). Drawing on insights from physiology, acoustics, and audiology, this essay presents listening as an interdependent brain-body-environment construct grounded in dynamic systems theory.Coupling, self-organization, and attractors are the central characteristics of dynamic systems. This article reviews the first of these aspects in order to develop a fuller understanding of how embodied auditory perception occurs. It introduces the mind-body problem before reviewing dynamic systems theory and exploring the notion of coupling in human hearing by way of current and original analogies drawn from engineering. It posits that the current use of the Watt governor device as an analogy for coupling is too simplistic to account for the coupling phenomena in the human ear.In light of this review of the physiological characteristics of the peripheral auditory system, coupling in hearing appears more variegated than originally thought and accounts for the diversity of perception among individuals, a cause for individual variance in how the mind emerges, which in turn affects academic performance. Understanding the constraints and affordances of the physical ear with regard to incoming sound supports the embodied listening paradigm.