bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Throughput Robotic Synthesis and Photoluminescence Characterization of Aqueous Multinary Copper–Silver Indium Chalcogenide Quantum Dots
Authors: Stroyuk Oleksandr , Raievska Oleksandra , Langner Stefan , Kupfer Christian , Barabash Anastasia , Solonenko Dmytro , Azhniuk Yuriy , Hauch Jens , Osvet Andres , Batentschuk Miroslaw , Zahn Dietrich R. T. , Brabec Christoph J. 
Published: September 2021

AbstractThe feasibility of a high‐throughput robot‐assisted synthesis of complex Cu1‐xAgxInSySe1‐x (CAISSe) quantum dots (QDs) by spontaneous alloying of aqueous glutathione‐capped Ag–In–S, Cu–In–S, Ag–In–Se, and Cu–In–Se QDs is demonstrated. Both colloidal and thin‐film core CAISSe and core/shell CAISSe/ZnS QDs are produced and studied by high‐throughput semiautomated photoluminescence (PL) spectroscopy. The silver‐copper‐mixed QDs reveal clear evidence of a band bowing effect in the PL spectra and higher average PL lifetimes compared to the counterparts containing silver or copper only. The photophysical analysis of CAISSe and CAISSe/ZnS QDs indicates a composition‐dependent character of the nonradiative recombination in QDs. The rate of this process is found to be lower for mixed copper‐silver‐based QDs compared to Cu‐ or Ag‐only QDs. The combination of the band bowing effect and the suppressed nonradiative recombination of CAISSe QDs is beneficial for their applications in photovoltaics and photochemistry. The synergy of high‐throughput robotic synthesis and a high‐throughput characterization in this study is expected to grow into a self‐learning synthetic platform for the production of metal chalcogenide QDs for light‐harvesting, light‐sensing, and light‐emitting applications.
Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study
Authors: Pasta Andrea , Borro Paolo , Cremonini Anna Laura , Formisano Elena , Tozzi Giulia , Cecchi Stefano , Fresa Raffaele , Labanca Sara , Djahandideh Afscin , Sukkar Samir Giuseppe , Picciotto Antonino , Pisciotta Livia 
Published: September 2021

AbstractLysosomal acid lipase deficiency (LAL‐D) is an autosomal recessive disease characterized by hypoalphalipoproteinemia, mixed hyperlipemia, and fatty liver (FL) due to mutations in LIPAse A, lysosomal acid type (LIPA) gene. The rs1051338 single‐nucleotide polymorphism (SNP) in LIPA gene, in vitro, could adversely affect the LAL activity (LAL‐A). Nonalcoholic fatty liver disease (NAFLD) is often associated with metabolic syndrome, and the diagnosis requires the exclusion of excess of alcohol intake and other causes of hepatic disease. The aim of the study was to evaluate the impact of rs1051338 rare allele on lipid phenotype, severity of FL, and LAL‐A in patients suffering from dyslipidemia associated with NAFLD. We selected 74 subjects with hypoalphalipoproteinemia or mixed hyperlipemia and evaluated transaminases, liver assessment with controlled attenuation parameter (CAP), LAL‐A, rs1051338 SNP genotype. The presence of rare allele caused higher levels of triglycerides and hepatic transaminase and lower levels of high‐density lipoprotein cholesterol (HDL‐C). Multivariate analysis highlighted independent association between rare allele and FL severity in subjects with NAFLD. The rs1051338 SNP may modulate FL severity and atherogenic dyslipidemia in patients suffering from NAFLD.
EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers
Authors: Luna Yolba Raquel , Visentin Virgile , Hervé Caroline , Chiche Johanna , Ricci Jean‐Ehrland , Méneyrol Jérôme , Paillasse Michaël R. , Alet Nathalie 
Published: September 2021

AbstractTargeting the first protein complex of the mitochondrial electron transport chain (MC1) in cancer has become an attractive therapeutic approach in the recent years, given the metabolic vulnerabilities of cancer cells. The anticancer effect exerted by the pleiotropic drug metformin and the associated reduction in hypoxia‐inducible factor 1α (HIF‐1α) levels putatively mediated by MC1 inhibition led to the development of HIF‐1α inhibitors, such as BAY87‐2243, with a more specific MC1 targeting. However, the development of BAY87‐2243 was stopped early in phase 1 due to dose‐independent emesis and thus there is still no clinical proof of concept for the approach. Given the importance of mitochondrial metabolism during cancer progression, there is still a strong therapeutic need to develop specific and safe MC1 inhibitors. We recently reported the synthesis of compounds with a novel chemotype and potent action on HIF‐1α degradation and MC1 inhibition. We describe here the selectivity, safety profile and anti‐cancer activity in solid tumors of lead compound EVT‐701. In addition, using murine models of lung cancer and of Non‐Hodgkin's B cell lymphoma we demonstrated that EVT‐701 reduced tumor growth and lymph node invasion when used as a single agent therapy. LKB1 deficiency in lung cancer was identified as a potential indicator of accrued sensitivity to EVT‐701, allowing stratification and selection of patients in clinical trials. Altogether these results support further evaluation of EVT‐701 alone or in combination in preclinical models and eventually in patients.
Overexpression of EiKCS confers paraquat‐resistance in rice (Oryza sativaL.) by promoting the polyamine pathway
Authors: Luo Qiyu , Chen Shu , Zhu Jiazheng , Ye Laihua , Hall Nathan Daniel , Basak Suma , McElroy Joseph Scott , Chen Yong 
Published: September 2021

AbstractBACKGROUNDParaquat is used widely as one of the bipyridine herbicides, which generates reactive oxygen species to cause cell death. With a growing number of paraquat‐resistant weeds, the mechanism of paraquat‐resistance in plants remains unclear. This research verified the functions of a previously confirmed putative paraquat‐resistant gene, EiKCS, from paraquat‐resistant goosegrass by genetic engineering in a single overexpressing line in rice.RESULTSOverexpression of EiKCS improved paraquat resistance in transgenic rice (KCSox). Pre‐applied (12 h) exogenous spermidine (1.5 mmol L−1), alleviated the injury of paraquat in rice. Paraquat induced injury in KCSox was 19.57%, which was lower than 32.22% injury it induced in wild‐type (WT) rice. The paraquat‐resistant mechanism was through the increased activity of antioxidant enzymes and the overproduction of endogenous polyamines. The spermine content in KCSox was more than 30 μg mL−1, while that in WT rice was less than 5 μg mL−1. Quantitative proteomics showed that β‐ketoacyl‐coenzyme A (CoA) synthase (51.81 folds) encoded by the transgenic EiKCS gene promoted the synthesis of the proteins involved with the polyamine pathway. The synthesized putrescine was promoted by the arginine decarboxylase (ADC) pathway. The spermidine synthase I (1.10‐fold) and three eceriferum cofactors (CERs) were responsive to the paraquat stress. We validated putrescine (C18H20N2O2) spermidine (C28H31N3O3), and spermine (C38H42N4O4) in this study.CONCLUSIONEiKCS encoding β‐ketoacyl‐CoA synthase from goosegrass has been shown as an ideal candidate gene for engineering genetically modified organism (GMO) crops, as its overexpression does not only bring paraquat‐resistance, but also have potential benefits without decreasing yield and rice grain quality. © 2021 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Land management effects on wet aggregate stability and carbon content
Authors: Mikha Maysoon M. , Jin Virginia L. , Johnson Jane M. F. , Lehman R. Michael , Karlen Douglas L. , Jabro Jalal D. 
Published: September 2021

AbstractLand management affects soil structure and many other soil properties and processes. Our objectives were to evaluate soil organic C (SOC), aggregate size distribution, aggregate‐associated C, and soil structure as affected by long‐term land management and slope. A chronosequence of 38 on‐farm sites with low to high (5–18%) slopes was selected to evaluate 5–40 yr of management. The sites were classified as business as usual (BAU) cropland (BAU‐Crop), BAU pasture (BAU‐Past), newly established conservation reserve program (CRP) areas (CRP‐New), and established CRP (CRP‐Old). Soil samples were collected from the 0‐to‐5‐ and 5‐to‐15‐cm depth increments and processed for soil property measurements including fractionation by wet sieving into five aggregate size classes (>2,000, 1,000–2,000, 500–1,000, 250–500, and 53–250 μm). Within the surface 5 cm, mean weight diameter (MWD) and geometric mean diameter (GMD) were used to characterize soil structural stability. The BAU‐Past and CRP‐Old sites had 79% more macroaggregates (>2,000, 1,000–2,000, and 500–1,000 μm), 123% higher MWD, 38% higher GMD, and 47% higher SOC than BAU‐Crop or CRP‐New sites. The 5‐to‐15‐cm depth increment showed a similar but lower magnitude response. Aggregate‐associated C was quantified using a constant soil mass that reflected aggregate size distribution to prevent overestimating C content. Lower‐slope locations had more SOC, more macroaggregates, more C associated with macroaggregates, and higher GMD and MWD compared with high‐slope locations across all management classifications and soil depths. The results support our hypothesis that the high‐slop soils may benefits from specific management decisions than the lower‐sloping soils as a function of landscape property. We recommend reestablishing grassland on sloping land that is susceptible to excessive soil erosion, although those practices will likely take a long time to restore soil structural stability and SOC content to precultivation levels.
A bias correction method in meta‐analysis of randomized clinical trials with no adjustments for zero‐inflated outcomes
Authors: Zhou Zhengyang , Xie Minge , Huh David , Mun Eun‐Young 
Published: September 2021

SummaryMany clinical endpoint measures, such as the number of standard drinks consumed per week or the number of days that patients stayed in the hospital, are count data with excessive zeros. However, the zero‐inflated nature of such outcomes is sometimes ignored in analyses of clinical trials. This leads to biased estimates of study‐level intervention effect and, consequently, a biased estimate of the overall intervention effect in a meta‐analysis. The current study proposes a novel statistical approach, the Zero‐inflation Bias Correction (ZIBC) method, that can account for the bias introduced when using the Poisson regression model, despite a high rate of inflated zeros in the outcome distribution of a randomized clinical trial. This correction method only requires summary information from individual studies to correct intervention effect estimates as if they were appropriately estimated using the zero‐inflated Poisson regression model, thus it is attractive for meta‐analysis when individual participant‐level data are not available in some studies. Simulation studies and real data analyses showed that the ZIBC method performed well in correcting zero‐inflation bias in most situations.
A comprehensive study on security bug characteristics
Authors: Wei Ying , Sun Xiaobing , Bo Lili , Cao Sicong , Xia Xin , Li Bin 
Published: September 2021

AbstractSecurity bugs can catastrophically impact our increasingly digital lives. Designing effective tools for detecting and fixing software security bugs requires a deep understanding of security bug characteristics. In this paper, we conducted a comprehensive study on security bugs and proposed the classification criteria for security bug category, that is, root cause, consequence, and location. In addition, we selected 1076 bug reports from five projects (i.e., Apache Tomcat, Apache HTTP Server, Mozilla Firefox, Linux Kernel, and Eclipse) in the NVD for investigation. Finally, we investigated the correlation between the classification results and obtained some findings: (1) memory operation is the most common security bug; (2) the primary root causes of security bugs are CON (Configuration Error), INP (Input Validation Error), and MEM (Memory Error); (3) the severity of more than 40% of security bugs is high; (4) security bugs caused by INP mainly occur on web; and (5) security bugs caused by LOG (Logic Resource Error) usually lead to DoS (Denial of Service). We discussed these findings through data analysis, which can also help developers better understand the characteristics of security bugs.
Fabrication and Characterization of Dodecenyl Succinic Anhydride Modified Kudzu Starch
Authors: Zhao Yiguo , Khalid Nauman , Nakajima Mitsutoshi 
Published: September 2021

AbstractThe dodecenyl succinic anhydride (DDSA) modified kudzu starch is fabricated and characterized in this study. After modification, granule size of kudzu starch exhibits bigger than that of native kudzu starch. The viscosity of DDSA‐modified kudzu starch is increased in comparison with the native one. However, there is no detectable surface change of kudzu starch granules before and after modification. To elucidate the esterification between starch molecules and DDSA groups or octenyl succinic anhydride (OSA) groups, the characteristic peaks of DDSA‐modified or OSA‐modified kudzu starch are determined using Fourier transform infrared spectroscopy (FT‐IR). Moreover, differential scanning calorimetry (DSC) thermograms reveal that the gelatinization temperatures and enthalpy of modified kudzu starch are lower than that of the native counterpart. Stable O/W emulsions are obtained after storage at room temperature for 30 days, as the concentration of modified kudzu starch is above 2% (w/w) according to the results of oil droplet size and confocal laser scanning microscopy analysis. This study demonstrates that DDSA modification can improve properties of kudzu starch and then potentially broaden its applications.
Translanguaging Together: Building Bilingual Identities con Nuevos Amigos
Authors: Moses Lindsey , Hajdun Matt , Aguirre Ana Alvarado 
Published: September 2021

AbstractIn this article, the authors share their experiences creating and implementing a unit focused on supporting bilingual identities through integrating language domains and translanguaging with authentic writing experiences. Two dual‐language first‐grade teachers from Colombia and the US worked together to model, celebrate, and support the use of translanguaging as a meaningful communicative practice that encourages bilingual students to draw on all of their linguistic resources. The article includes the instructional progression used to support emergent bilingual first graders with writing letters and creating interactive videos with the purpose of making new international friends and learning about each other's communities. Practical suggestions with examples provide ideas for building supportive bilingual communities, selecting and reading aloud texts with translanguaging practices, building contextualized vocabulary, developing oral language, supporting letter and video creations, and engaging with and responding to bilingual peers.
Research on the efficient water‐absorbing ceramsite generated by dredged sediments in Dian Lake–China and coal fly ash
Authors: Cai Yingying , Gao Haijun , Qu Guangfei , Ning Ping , Hu Yinghui , Zou Hongmei , Ren Nanqi 
Published: September 2021

AbstractIn order to transform the dredged sediment (DS) into an efficient water‐absorbing ceramsite (EWAC), the coal fly ash (CFA) and expansion agent were used to blend, expand, and sinter with the DS in the Dian Lake–China. A new type of high EWAC was prepared with the absorption ratio of 66.71%, which was much higher than similar products. The heavy metals leaching (HML) of EWAC showed that the concentration of As was 0.90 mg/L and the Hg, Pb, Cd, and Cr were too low to be detected. The characterization analysis showed that the EWAC cross section contained a lot of hydroxyl, ether, and P‐Cl hydrophilic group by Fourier transform infrared (FT‐IR), scanning electron microscope (SEM), and Brunauer–Emmett–Teller (BET) specific surface area (SSA) test method. The above groups and structures could greatly improve the water absorption (WA) performance of the EWAC. What's more, the SSA of the EWAC could reach 4.468 m2/g. The results of Comsol Multiphysics indicated that the SSA and average pore size (APS) of the EWACs were 10 and 6 times higher than the commercial ceramsites, respectively. The research provided the utilization of the DS with technical and theoretical basis for the construction of sponge city.Practitioner points

The article was focus on the utilization of dredged sediment (DS) and coal fly ash (CFA) for the basic material preparation technology and its toxicity test as the sponge city.
First, the raw materials were the DS in Dian Lake (Kunming, Yunnan, China) and CFA (thermal power plants), which were all belonged to the hazardous solid waste and was made to the efficient water‐absorbing ceramsite (EWAC).
Second, the water absorption (WA) performance of the EWAC was improved greatly whose absorption ratio was much higher than similar products reached 66.71%.
The specific surface area (SSA) and average pore size (APS) of the EWACs were 10 and 6 times higher than the commercial ceramsites (CCs), respectively.
Finally, the heavy metals leaching (HML) of As was 0.90 mg/L, and the HML of Hg, Pb, Cd, and Cr was all lower than 0.05 mg/L, which could not only not cause secondary pollution but provide the new ideas for the resource utilization of large amount of DS. So, we thought this article was suitable for the journal.
Thermal shock analysis of functionally graded sandwich curved beams using a new layerwise theory
Authors: Pandey Shashank , Pradyumna S. 
Published: September 2021

AbstractThis work for the first time presents a simple, accurate and straightforward finite element formulation that requires a C0 continuity of transverse displacement for the transient stress analysis of curved beams under thermal shock using a new layerwise theory. The FGM sandwich curved beam is considered to be made of three layers in which the top, middle and the bottom layer is considered to be made of pure ceramic, functionally graded material (FGM) core and pure metal constituents, respectively. The proposed new layerwise theory assumes a higher‐order displacement field for FGM core and first‐order displacement field for both top and bottom layers. The material properties are assumed to be temperature‐dependent. The governing differential equation for the present investigation is formulated using Hamilton's principle. A wide range of comparison studies are presented to establish the accuracy of the present layerwise finite element formulation. A parametric study is conducted to show the simplicity and wider applicability of the proposed formulation. It is shown here that by selecting an appropriate value of volume fraction index, core to facesheet thickness ratio, magnitude of thermal shock, curvature and thickness ratio, the transient thermal stresses induced in FGM sandwich curved beams can be reduced substantially.
Understanding the Barriers That Slow Firms Shifting from Products to Services
Authors: West Shaun , Gaiardelli Paolo , Saccani Nicola 
Published: September 2021

AbstractThis chapter provides an introduction to “servitization” and, in particular, why manufacturing firms are moving into services and how the transition has been slowed. The first section provides an overview of how this book works. It then moves on to introduce product-service systems and the rationale for servitization from the perspective of a manufacturing firm. This is then examined from different perspectives and uses the product lifecycle as an anchor. It moves on to describe the journey into services and then a complex system that often exists within industrial product-service systems. Finally, the seven barriers are explored before providing additional reading.
Incidence, risk factors and clinical course of pyogenic spondylodiscitis patients with pulmonary embolism
Authors: Dubinski Daniel , Won Sae-Yeon , Keil Fee , Behmanesh Bedjan , Dosch Max , Baumgarten Peter , Bernstock Joshua D. , Seifert Volker , Freiman Thomas M. , Gessler Florian 
Published: September 2021

Abstract
Purpose
In patients with pyogenic spondylodiscitis, surgery is considered the treatment of choice to conduct proper debridement, stabilise the spine and avoid extended bed rest, which in turn is a risk factor for complications such as deep vein thrombosis and pulmonary embolism.

Methods
We conducted a retrospective clinical study with analysis of a group of 99 patients who had undergone treatment for pyogenic discitis at our institution between June 2012 and August 2017. Included parameters were age, sex, disease pattern, the presence of deep vein thrombosis, resuscitation, in-hospital mortality, present anticoagulation, preexisting comorbidities, tobacco abuse, body mass index, microbiological germ detection and laboratory results.

Results
Among the analysed cohort, 12% of the treated patients for pyogenic spondylodiscitis suffered from a radiologically confirmed pulmonary embolism. Coronary heart disease (p < 0.01), female sex (p < 0.01), anticoagulation at admission (p < 0.01) and non-O blood type (p < 0.001) were associated with development of pulmonary embolism. Pulmonary embolism was significantly associated with resuscitation (p < 0.005) and deep vein thrombosis (p < 0.001). Neurosurgery was not associated with increased risk for pulmonary embolism compared to conservative-treated patients (p > 0.05).

Conclusion
Surgery for pyogenic spondylodiscitis was not associated with an elevated risk of pulmonary embolism in our analysis. However, we describe several risk factors for pulmonary embolism in this vulnerable cohort. Prospective studies are necessary to improve prevention and postoperative management in patients with pyogenic spondylodiscitis.
A generalized Kalman filter with its precision in recursive form when the stochastic model is misspecified
Authors: Teunissen P. J. G. , Khodabandeh A. , Psychas D. 
Published: September 2021

AbstractIn this contribution, we introduce a generalized Kalman filter with precision in recursive form when the stochastic model is misspecified. The filter allows for a relaxed dynamic model in which not all state vector elements are connected in time. The filter is equipped with a recursion of the actual error-variance matrices so as to provide an easy-to-use tool for the efficient and rigorous precision analysis of the filter in case the underlying stochastic model is misspecified. Different mechanizations of the filter are presented, including a generalization of the concept of predicted residuals as needed for the recursive quality control of the filter.