bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endurance exercise and the risk of cardiovascular pathology in men: a comparison between lifelong and late-onset endurance training and a non-athletic lifestyle - rationale and design of the Master@Heart study, a prospective cohort trial
Authors: De Bosscher Ruben , Dausin Christophe , Claus Piet , Bogaert Jan , Dymarkowski Steven , Goetschalckx Kaatje , Ghekiere Olivier , Belmans Ann , Van De Heyning Caroline M , Van Herck Paul , Paelinck Bernard , El Addouli Haroun , La Gerche André , Herbots Lieven , Heidbuchel Hein , Willems Rik , Claessen Guido 
Published: April 2021

IntroductionLow and moderate endurance exercise is associated with better control of cardiovascular risk factors, a decreased risk of coronary artery disease and atrial fibrillation (AF). There is, however, a growing proportion of individuals regularly performing strenuous and prolonged endurance exercise in which the health benefits have been challenged. Higher doses of endurance exercise have been associated with a greater coronary atherosclerotic plaque burden, risk of AF and myocardial fibrosis (MF).Methods and analysisMaster@Heart is a multicentre prospective cohort study aiming to assess the incidence of coronary atherosclerosis, AF and MF in lifelong endurance athletes compared to late-onset endurance athletes (initiation of regular endurance exercise after the age of 30 years) and healthy non-athletes.The primary endpoint is the incidence of mixed coronary plaques. Secondary endpoints include coronary calcium scores, coronary stenosis >50%, the prevalence of calcified and soft plaques and AF and MF presence. Tertiary endpoints include ventricular arrhythmias, left and right ventricular function at rest and during exercise, arterial stiffness and carotid artery intima media thickness.Two hundred male lifelong athletes, 200 late-onset athletes and 200 healthy non-athletes aged 45–70 will undergo comprehensive cardiovascular phenotyping using CT, coronary angiography, echocardiography, cardiac MRI, 12-lead ECG, exercise ECG and 24-hour Holter monitoring at baseline. Follow-up will include online tracking of sports activities, telephone calls to assess clinical events and a 7-day ECG recording after 1 year.Ethics and disseminationLocal ethics committees approved the Master@Heart study. The trial was launched on 18 October 2018, recruitment is complete and inclusions are ongoing.Trial registration numberNCT03711539.
Contemporary use of excimer laser in percutaneous coronary intervention with indications, procedural characteristics, complications and outcomes in a university teaching hospital
Authors: Jawad-Ul-Qamar Muhammad , Sharma Harish , Vetrugno Vincenzo , Sandhu Kully , Ludman Peter F , Doshi Sagar N , Townend Jonathan N , Osheiba Mohammed , Zaphiriou Alex , Khan Sohail Q 
Published: April 2021

BackgroundExcimer laser coronary atherectomy (ELCA) can be used as an adjunctive percutaneous coronary intervention treatment for challenging, heavily calcified lesions. Although previous studies have documented high rates of complication and restenosis, these predate the introduction of the smaller 0.9 mm laser catheter. As the coronary complexity has increased, there has been a renewed interest in the ELCA. This study investigates the indications, procedural characteristics, complications and outcomes of ELCA in a contemporary coronary interventional practice.MethodsThis single-centre study retrospectively analysed 50 patients treated with ELCA between January 2013 and January 2019.ResultsPatients had a mean age of 67.9±11.4 years with a male predominance (65.3%). 25 (50%) cases were performed in patients with stable angina. Failure to deliver the smallest available balloon/microcatheter was the most frequent indication in 32 (64%) cases for ELCA use. 30 (60%) of the procedures were performed via radial access. The 0.9 mm X-80 catheter was used in 41 (82%) of cases, delivering on average 9000±3929 pulses. ELCA-related complications included 2 coronary dissections and 1 perforation, all of which were covered with stents. No major complications could be directly attributed to the use of ELCA. There was one death and one case of stent thrombosis within 30 days of the procedure.ConclusionELCA can be performed safely via the radial approach with a 0.9 mm catheter with a high success rate by suitably trained operators. The low procedure-related complications with contemporary techniques make this a very useful tool for complex coronary interventions, especially for difficult to dilate lesions and chronic total occlusion vessels.
The effects of different spacing allowances in the pullet phase on the eggshell and bone quality of hens in the laying phase
Authors: Pereira A. , Akbari Moghaddam Kakhki R. , Kiarie E.G. 
Published: April 2021

Eggshell and bone quality were investigated at 72 wk of age (WOA) using Lohmann Brown and Dekalb White hens raised with a rearing spacing allowance (SA) of 247 and 299 cm2·bird−1 from days 0 to 16 before being transferred to a common SA (755 cm2·bird−1) for lay cycle. Eggshell thickness, breaking strength, along with tibia and femur weight, breaking strength, length, and ash were measured at 72 WOA. Strain and SA did not interact on any above parameter (P > 0.05). Hens reared in high SA during the pullet phase had heavier tibia and more femur ash, indicating rearing environment during the pullet phase influences the bone quality of hens in the late laying stage (P < 0.05).
4,4′-Dichloro-diphenyl diselenide modulated oxidative stress that differently affected peripheral tissues in streptozotocin-exposed mice
Authors: Marques Luiza S. , Zborowski Vanessa A. , Heck Suélen O. , Fulco Bruna C.W. , Nogueira Cristina W. 
Published: April 2021

Streptozotocin (STZ) is a substance used experimentally to induce a diabetes model, a metabolic disease associated with oxidative tissue damage. This study evaluated if 4-4′-dichloro-diphenyl diselenide (p-ClPhSe)2 modulates oxidative stress in peripheral tissues of diabetic mice. Male Swiss mice received a single STZ injection (i.p.) at a dose of 200 mg/kg or its vehicle and were treated with (p-ClPhSe)2 (7 days, 5 mg/kg) or metformin (200 mg/kg, twice per day). After, the mice were euthanized to collect liver, kidney, and skeletal muscle samples. In the liver, (p-ClPhSe)2 reduced thiobarbituric acid reactive substances (TBARS) and protein carbonyl levels and normalized the superoxide dismutase activity in STZ-treated mice. In the kidney, (p-ClPhSe)2 reversed the increase in the reactive species levels but not the catalase (CAT) activity reduction in STZ-treated mice. There was no evidence of oxidative damage in the skeletal muscle of STZ-treated mice, but an increase in the CAT activity and a reduction in non-protein thiol levels were found. (p-ClPhSe)2 did not reverse a decrease in hepatic and renal δ-aminolevulinic acid dehydratase activity in STZ-treated mice. The results show that the liver and kidney of STZ-treated mice were more susceptible to oxidative stress. This study reveals that (p-ClPhSe)2 modulated oxidative stress, which differently affected peripheral tissues of diabetic mice.
Polyphase gold mineralization at the Yaou deposit, French Guiana
Authors: Combes Vincent , Eglinger Aurélien , André-Mayer Anne-Sylvie , Teitler Yoram , Heuret Arnauld , Gibert Pierre , Béziat Didier 
Published: April 2021

Abstract

The Yaou deposit, located in French Guiana within the Guiana Shield, is one of the most promising gold deposits of the regional Paleoproterozoic greenstone belt. It displays numerous quartz monzodiorite bodies aligned along a sinistral shear zone where a five-deformation phases model is established at the camp scale. The ductile D
1/2YA
phase is responsible for the main penetrative foliation while the D
3YA
phase is related to shearing. An intrusive event is identified as being pre to syn-D
3YA
. The following phase D
4YA
represents a brittle quartz-carbonate veining set hosted preferentially within intrusive bodies and along the shear zone. A local D
5YA
brecciation event crosscuts the D
4YA
veins. Among this deformation history, two auriferous events (D
3YA
and D
4YA
) control the overall grade of the Yaou gold deposit. More specifically, most of the Au grade is associated with the main economic D
4YA
veining event, where the gold is visible and linked to Py
4
within an ankerite/hematite rich alteration halo. At the microscopic scale, results of
in situ
analyses using LA-ICP-MS on pyrite show that metasediment-hosted Py
0
is a primary source of submicroscopic gold having a low contribution to the total endowment. Py
3
shows some gold content due to possible remobilization of Au
D0YA
. Gold in Py
4
is found as submicroscopic gold, as micro-inclusions and as infilling fractures in association with elements such as Te, Ag and Bi. Most contribution to the Au grade is from micro-inclusions and, to a lesser extent, from free and submicroscopic gold. The ore shoot locations are lithologically controlled for Au
D0YA
(metasedimentary unit-hosted), structurally controlled (shear zone-hosted) for Au
D3YA
and rheologically controlled for the Au
D4YA
(intrusion-hosted). The deposit is clearly polyphase both at the macroscopic and the microscopic scales, invisible gold is associated with As whereas visible gold is observed as inclusions in pyrite with high contents of Ag, Te and Bi. We define an early low-grade enrichment of Au
D0YA
to Au
D3YA
followed by a later high-grade event, Au
D4YA
supporting polyphase mineralization processes. This study confirms that orogenic gold deposits can be formed by remobilization and/or new gold inputs during multiple deformation, veining and hydrothermal events.
360-Degree VR Video Watermarking Based on Spherical Wavelet Transform
Authors: Liu Yanwei , Liu Jinxia , Argyriou Antonios , Ma Siwei , Wang Liming , Xu Zhen 
Published: April 2021

Similar to conventional video, the increasingly popular 360

virtual reality (VR) video requires copyright protection mechanisms. The classic approach for copyright protection is the introduction of a digital watermark into the video sequence. Due to the nature of spherical panorama, traditional watermarking schemes that are dedicated to planar media cannot work efficiently for 360

VR video. In this article, we propose a spherical wavelet watermarking scheme to accommodate 360

VR video. With our scheme, the watermark is first embedded into the spherical wavelet transform domain of the 360

VR video. The spherical geometry of the 360

VR video is used as the host space for the watermark so that the proposed watermarking scheme is compatible with the multiple projection formats of 360

VR video. Second, the just noticeable difference model, suitable for head-mounted displays (HMDs), is used to control the imperceptibility of the watermark on the viewport. Third, besides detecting the watermark from the spherical projection, the proposed watermarking scheme also supports detecting watermarks robustly from the viewport projection. The watermark in the spherical domain can protect not only the 360

VR video but also its corresponding viewports. The experimental results show that the embedded watermarks are reliably extracted both from the spherical and the viewport projections of the 360

VR video, and the robustness of the proposed scheme to various copyright attacks is significantly better than that of the competing planar-domain approaches when detecting the watermark from viewport projection.
Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors
Authors: Wang Lin , Londono Luz M. , Cowell Jessica , Saatci Ozge , Aras Mertkaya , Ersan Pelin G. , Serra Sara , Pei Hong , Clift Renee , Zhao Qiping , Phan Kim B. , Huang Lei , LaBarre Michael J. , Li Xiaoming , Shepard H. Michael , Deaglio Silvia , Linden Joel , Thanos Christopher D. , Sahin Ozgur , Cekic Caglar 
Published: April 2021

Abstract

Extracellular adenosine in tumors can suppress immune responses and promote tumor growth. Adenosine deaminase 2 (ADA2) converts adenosine into inosine. The role of ADA2 in cancer and whether it can target adenosine for cancer therapy has not been investigated. Here we show that increased ADA2 expression is associated with increased patient survival and enrichment of adaptive immune response pathways in several solid tumor types. Several ADA2 variants were created to improve catalytic efficiency, and PEGylation was used to prolong systemic exposure. In mice, PEGylated ADA2 (PEGADA2) inhibited tumor growth by targeting adenosine in an enzyme activity–dependent manner and thereby modulating immune responses. These findings introduce endogenous ADA2 expression as a prognostic factor and PEGADA2 as a novel immunotherapy for cancer.

Significance:
This study identifies ADA2 as a prognostic factor associated with prolonged cancer patient survival and introduces the potential of enzymatic removal of adenosine with engineered ADA2 for cancer immunotherapy.
A comprehensive flood inundation mapping for Hurricane Harvey using an integrated hydrological and hydraulic model
Authors: Chen Mengye , Li Zhi , Gao Shang , Luo Xiangyu , Wing Oliver E. J. , Shen Xinyi , Gourley Jonathan J. , Kolar Randall L. , Hong Yang 
Published: April 2021

AbstractAs climate change will increase the frequency and intensity of precipitation extremes and coastal flooding, there is a clear need for an integrated hydrology and hydraulic system that has the ability to model the hydrologic conditions over a long period and the flow dynamic representations of when and where the extreme hydrometeorological events occur. This system coupling provides comprehensive information (flood wave, inundation extents and depths) about coastal flood events for emergency management and risk minimization. This study provides an integrated hydrologic and hydraulic coupled modeling system that is based on the Coupled Routing and Excessive Storage (CREST) model and the Australia National University- Geophysics Australia (ANUGA) model to simulate flood. Forced by the near-real-time Multi-Radar Multi-Sensor (MRMS) Quantitative Precipitation Estimates (QPEs), this integrated modeling system was applied during the 2017 Hurricane Harvey event to simulate the streamflow, the flood extent, and the inundation depth. The results were compared with post-event Water High Mark (WHM) survey data and its interpolated flood extent by the United States Geological Survey (USGS) and the Federal Emergency Management Agency (FEMA) flood insurance claims, as well as a satellite-based flood map, the National Water Model (NWM) and the Fathom (LISFLOOD-FP) model simulated flood map. The proposing hydrologic and hydraulic model simulation indicated that it could capture 87% of all flood insurance claims within the study area, and the overall error of water depth was 0.91 meters, which is comparable to the mainstream operational flood models (NWM and Fathom).
Cyclonic eddies in the West Greenland Boundary Current System
Authors: Pacini Astrid , Pickart Robert S. , Le Bras Isabela A. , Straneo Fiammetta , Holliday N.P. , Spall M.A. 
Published: April 2021

AbstractThe boundary current system in the Labrador Sea plays an integral role in modulating convection in the interior basin. Four years of mooring data from the eastern Labrador Sea reveal persistent mesoscale variability in the West Greenland boundary current. Between 2014 and 2018, 197 mid-depth intensified cyclones were identified that passed the array near the 2000 m isobath. In this study, we quantify these features and show that they are the downstream manifestation of Denmark Strait Overflow Water (DSOW) cyclones. A composite cyclone is constructed revealing an average radius of 9 km, maximum azimuthal speed of 24 cm/s, and a core propagation velocity of 27 cm/s. The core propagation velocity is significantly smaller than upstream near Denmark Strait, allowing them to trap more water. The cyclones transport a 200-m thick lens of dense water at the bottom of the water column, and increase the transport of DSOW in the West Greenland boundary current by 17% relative to the background flow. Only a portion of the features generated at Denmark Strait make it to the Labrador Sea, implying that the remainder are shed into the interior Irminger Sea, are retroflected at Cape Farewell, or dissipate. A synoptic shipboard survey east of Cape Farewell, conducted in summer 2020, captured two of these features which shed further light on their structure and timing. This is the first time DSOW cyclones have been observed in the Labrador Sea—a discovery that could have important implications for interior stratification.
Minimally Invasive Mastectomy Could Achieve Non-inferior Oncological Outcome in Appropriately Selected Patients: Propensity Matched Analysis of the National Cancer Database
Authors: Cao Lifen , Shenk Robert , Miller Megan E. , Towe Christopher 
Published: April 2021

Background Minimally invasive mastectomy (MIM) was emerged as an approach to decrease morbidity and increase patient satisfaction through improved cosmetic results; however, there is a paucity of data regarding the long-term oncologic outcomes of these minimally invasive approaches. Methods Patients who underwent mastectomy procedures were identified in the National Cancer Database (2010-2016). Patients were categorized as MIM or open mastectomy. A 1:1 propensity match was performed to balance the bias on reconstruction, nipple sparing, lymph node procedures, and other confounding factors between the cohorts. Short- and long-term outcomes were compared. Results A total of 328 811 patients met the criteria: 327 643 (99.6%) received open mastectomy and 1168 (.4%) received MIM. Propensity match identified 384 “pairs” of MIM and open mastectomy patients. Among them, MIM was associated with shorter length of stay (LOS) (mean 1.3 vs. 1.06 days, P = .003). No differences were observed in the rates of positive margins, unplanned readmissions, or 90-day mortality between the 2 operative approaches. Overall survival (OS) was equivalent between MIM and open mastectomy patients. Cox proportional hazard regression showed no effect of the procedure performed on OS. Discussion MIM is associated with shorter LOS, and it is non-inferior to open mastectomy in terms of other short-term outcomes and long-term oncologic survival outcomes. These data suggest that MIM may be considered in appropriately selected breast cancer patients as an additional approach to the community.
Patient Case Formulations and Oppressive Disability Discourses in Occupational Therapy Education
Authors: Grenier Marie-Lyne 
Published: April 2021

Background. Patient case formulations have become a standard feature in occupational therapy (OT) education. Despite their demonstrated benefits in optimizing student learning, patient case formulations may unintentionally convey oppressive disability discourses. Purpose. The purpose of this paper is to illustrate and invite critical reflection on the use of patient case formulations in reinforcing ableist discourses and assumptions in OT education and practice. Key Issues. Through the lens of critical disability theory and Crip theory, the author demonstrates how patient case formulations are often reflective of institutionalized ableism that functions to support oppressive disability discourses in the profession, contributing to harmful healthcare practices. Implications. The ongoing use of patient case formulations rooted in oppressive disability discourses perpetuates oppressive constructions of disabled people in OT education and practice. A radical shift towards pedagogical materials and practices that support identity-affirming disability discourses would be more aligned with the profession’s expressed values.
From the participatory turn of administrations to the bureaucratisation of participatory democracy: study based on the French case
Authors: Gourgues Guillaume , Mazeaud Alice , Nonjon Magali 
Published: April 2021

This article sets out to contribute to the debate on the participatory turn of public action and the administration by studying the profile and work of civil servants dedicated to citizen participation within French local administrations. Counter to the rhetoric advocating the participatory modernisation of the administration, an analysis of the day-to-day work of civil servants in charge of participation makes it possible to grasp the dynamics behind the bureaucratisation of citizen participation. Without actually shaking up administrative routines, the specialist civil servants invent new routines essentially intended to maintain the arrangements set up, even when these have little or no effect on the conduct of public action. Points for practitioners This article provides an insight into the processes of administering citizen participation in France according to a double logic of specialisation and dissemination, and analyses the practical aspects of participatory work within the administrations.
Comparison of the corticosteroid injection and hyaluronate in the treatment of chronic subacromial bursitis: A randomized controlled trial
Authors: Hsieh Lin-Fen , Lin Yi-Jia , Hsu Wei-Chun , Kuo Ying-Chen , Liu Yu-Chia , Chiang Yi-Pin , Wang Chun-Ping 
Published: April 2021

Objective: To analyse the effectiveness of corticosteroid (CS) and hyaluronic acid (HA) subacromial – subdeltoid (SASD) injection compared with normal saline (NS) in patients with chronic subacromial bursitis (CSB). Design: A prospective three-arm double-blinded randomised controlled trial. Setting: Rehabilitation department of two teaching hospitals. Subjects: Patients with CSB ( N = 186) divided into CS ( N = 68), HA ( N = 60), and NS ( N = 58) groups. Interventions: Three SASD injections under ultrasound guidance: group A, 20 mg of triamcinolone; group B, 2.5 mL of HA; and group C, 2.5 mL of NS. Outcome measures: The primary outcome measures were the pain visual analogue scale (VAS) score at eight weeks. The secondary outcomes were scores on the Shoulder Pain and Disability Index (SPADI) and Shoulder Disability Questionnaire. Results: At eight weeks, the pain VAS scores during activity were 2.56 ± 2.29, 3.65 ± 2.50, and 4.71 ± 2.83 in the CS, HA, and NS groups, respectively (CS vs NS, P < 0.001; HA vs NS, P = 0.013; CS vs HA, P = 0.010). SPADI scores were 40.83 ± 21.75, 36.92 ± 22.78, and 33.35 ± 23.38 in the CS, HA, and NS groups, respectively (CS vs NS, P < 0.001; HA vs NS, P = 0.197; CS vs HA, P = 0.004). Conclusion: Ultrasound-guided corticosteroid injection into the subacromial – subdeltoid bursa was proven to be effective and superior to hyaluronic acid and normal saline injection for treating CSB. Hyaluronic acid injection was only marginally more effective than normal saline injection. Trial Registration: ClinicalTrials.gov: NCT02702206