bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Clinical Translation of a Perioperative Nomogram Incorporating Free Fatty Acids to Predict Poor Outcome of Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment
Authors: Wang Yongyi , Xie Yongfan , Wang Houzhong , Zhang Jifang , Li Chuanfeng , Chen Feng , Ren Chengtao , Xu Zhiming , Liu Mingxing , Li Luo , Li Tong , Wang Weimin 
Published: July 2021

Objective: A reliable prediction of clinical outcome is important for clinicians to set appropriate medical strategies in treating patients with aneurysmal subarachnoid hemorrhage (aSAH). In this study, we aim to establish a perioperative nomogram involving serum lipid signatures for predicting poor outcomes at 3 months in patients with aSAH following endovascular therapy.Methods: Data of patients with aSAH receiving endovascular therapy were collected. Univariable and multivariable analyses were performed to screen independent predictors related to unfavorable outcomes defined by the modified Rankin Scale (mFS) ≥3. A novel nomogram based on these significant features was conducted. The clinical application of this nomogram was assessed by decision curve analysis (DCA) and clinical impact curve.Results: A total number of patients included in this study were 213 (average age 58.9 years, 65.7% female), representing a poor 3-month outcome rate of 48.8%. Free fatty acid (FFA) levels on admission were efficient in predicting poor outcomes compared with other contents in serum lipids. Univariable and multivariable analyses revealed advanced age (P = 0.034), poor Hunt Hess (HH) (odds ratio, OR = 3.7, P &lt; 0.001) and mFS (OR = 6.0, P &lt; 0.001), aneurysms in the posterior circulation (OR = 4.4, P = 0.019), and higher FFA levels on admission (OR = 3.1, P = 0.021) were negative independent predictors of poor 3 months outcome. A novel nomogram composed of these significant features presented a concordance index (C-index) of 0.831 while the practical benefit was validated by DCA and clinical impact curve. An online calculator based on R programming promoted the clinical application of this nomogram.Conclusion: Nomogram involving age, HH grade, mFS, aneurysm location, and serum FFA levels was sufficient to provide an individualized prediction of 3-month poor outcome for each patient with aSAH who underwent endovascular therapy.
Neutral Effects of Combined Treatment With GLP-1R Agonist Exenatide and MR Antagonist Potassium Canrenoate on Cardiac Function in Porcine and Murine Chronic Heart Failure Models
Authors: Demkes Evelyne J. , Wenker Steven , Silvis Max J. M. , van Nieuwburg Martijn M. J. , Visser M. Joyce , Jansen Marlijn S. , Brans Maike A. D. , Velema Evelyn , Sluijter Joost P. G. , Hoefer Imo E. , de Kleijn Dominique P. V. , Timmers Leo , de Jager Saskia C. A. 
Published: July 2021

Background: Ischemia-reperfusion and cardiac remodeling is associated with cardiomyocyte death, excessive fibrosis formation, and functional decline, eventually resulting in heart failure (HF). Glucagon-like peptide (GLP)-1 agonists are reported to reduce apoptosis and myocardial infarct size after ischemia-reperfusion. Moreover, mineralocorticoid receptor antagonists (MRAs) have been described to reduce reactive fibrosis and improve cardiac function. Here, we investigated whether combined treatment with GLP-1R agonist exenatide and MRA potassium canrenoate could minimize cardiac injury and limit HF progression in animal models of chronic HF.Methods and Results: Forty female Topigs Norsvin pigs were subjected to 150 min balloon occlusion of the left anterior descending artery (LAD). Prior to reperfusion, pigs were randomly assigned to placebo or combination therapy (either low dose or high dose). Treatment was applied for two consecutive days or for 8 weeks with a continued high dose via a tunneled intravenous catheter. Using 2,3,5-Triphenyltetrazolium chloride (TTC) staining we observed that combination therapy did not affect the scar size after 8 weeks. In line, left ventricular volume and function assessed by three-dimensional (3D) echocardiography (baseline, 7 days and 8 weeks), and cardiac magnetic resonance imaging (CMR, 8 weeks) did not differ between experimental groups. In addition, 36 C57Bl/6JRj mice underwent permanent LAD-occlusion and were treated with either placebo or combination therapy prior to reperfusion, for two consecutive days via intravenous injection, followed by continued treatment via placement of osmotic mini-pumps for 28 days. Global cardiac function, assessed by 3D echocardiography performed at baseline, 7, 14, and 28 days, did not differ between treatment groups. Also, no differences were observed in cardiac hypertrophy, assessed by heart weight/bodyweight and heart weight/tibia length ratio.Conclusion: In the current study, combined treatment with GLP-1R agonist exenatide and MR antagonist potassium canrenoate did not show beneficial effects on cardiac remodeling nor resulted in functional improvement in a small and large animal chronic HF model.
Adverse Childhood Experiences Among 28,047 Norwegian Adults From a General Population
Authors: Haugland Siri H. , Dovran Anders , Albaek Ane U. , Sivertsen Børge 
Published: July 2021

Aim: The purpose of this study was to estimate the prevalence of adverse childhood experiences (ACEs) among Norwegian adults from a general population and to identify potential associations with demographic and socioeconomic characteristics.Methods: A randomly drawn sample (N = 61,611) from the public registry of inhabitants was invited to participate in the Norwegian Counties Public Health Survey. The present study was based on online responses from 28,047 adults ≥18 years (mean age: 46.9 years, SD = 16.03). Log-link binomial regression analyses were performed to examine associations between four measures of ACEs (family conflict, lack of adult support, bad memories, and difficult childhood) and demographic (age, gender, civil status, parental divorce) and socioeconomic characteristics (education level, perceived financial situation, and welfare benefits).Results: Single individuals and those with parents that divorced during childhood were at elevated risk of all four ACEs. The risk varied to some degree between the sexes. The prevalence of ACEs declined with increasing age. We found a consistent social gradient that corresponded to the frequency of ACEs for all three socioeconomic characteristics investigated. The risks were highest for those in the lowest socioeconomic levels (RR: 1.53, 95% CI: 1.32–1.78 to RR: 4.95, CI: 4.27–5.74).Conclusions: Public health strategies should direct more attention to the interplay between ACEs and socioeconomic factors. Welfare services should be sensitive to ACEs among their service recipients.
Do Community Free-Medication Service Policy Improve Patient Medication Adherence? A Cross-Sectional Study of Patients With Severe Mental Disorders in Beijing Community
Authors: Zhu Junli , Huang Qingzhi , Lu Wei , Chen Yun , Li Bin , Xu Ying , Xi Rui , Li Dan 
Published: July 2021

Background: Nowadays, mental health problems have become a major concern affecting economic and social development, with severe mental health disorders being the top priority. In 2013, Beijing began to implement the Community Free-Medication Service policy (CFMS). This article aims to evaluate the effect of the policy on medication adherence.Methods: In this study, multi-stage sampling was used to select representative patients as samples. Some of the baseline data were obtained by consulting the archives, and information about patient medication adherence measured by Brooks Medication Adherence Scale was obtained through face-to-face interviews. Logistic regression was used to examine the impact of the policy.Results: Policy participation had a significant positive impact on medication adherence (OR = 1.557). The effect of policy participation on medication adherence in the Medication-only mode and Subsidy-only mode were highly significant, but it was not significant in the Mixed mode.Conclusion: This study found that the CFMS in Beijing as an intervention is effective in improving the medication adherence of community patients. However, the impact of the policy is not consistent among service modes. Reinforcement magnitude and frequency should be considered when designing reinforcement interventions.
Highlighting the Biotechnological Potential of Deep Oceanic Crust Fungi through the Prism of Their Antimicrobial Activity
Authors: Quemener Maxence , Dayras Marie , Frotté Nicolas , Debaets Stella , Le Meur Christophe , Barbier Georges , Edgcomb Virginia , Mehiri Mohamed , Burgaud Gaëtan 
Published: July 2021

Among the different tools to address the antibiotic resistance crisis, bioprospecting in complex uncharted habitats to detect novel microorganisms putatively producing original antimicrobial compounds can definitely increase the current therapeutic arsenal of antibiotics. Fungi from numerous habitats have been widely screened for their ability to express specific biosynthetic gene clusters (BGCs) involved in the synthesis of antimicrobial compounds. Here, a collection of unique 75 deep oceanic crust fungi was screened to evaluate their biotechnological potential through the prism of their antimicrobial activity using a polyphasic approach. After a first genetic screening to detect specific BGCs, a second step consisted of an antimicrobial screening that tested the most promising isolates against 11 microbial targets. Here, 12 fungal isolates showed at least one antibacterial and/or antifungal activity (static or lytic) against human pathogens. This analysis also revealed that Staphylococcus aureus ATCC 25923 and Enterococcus faecalis CIP A 186 were the most impacted, followed by Pseudomonas aeruginosa ATCC 27853. A specific focus on three fungal isolates allowed us to detect interesting activity of crude extracts against multidrug-resistant Staphylococcus aureus. Finally, complementary mass spectrometry (MS)-based molecular networking analyses were performed to putatively assign the fungal metabolites and raise hypotheses to link them to the observed antimicrobial activities.
Microbiological Attributes and Performance of the Bacterial Community in Brazilian Cerrado Soil with Different Cover Crops
Authors: de Lima Sebastião Ferreira , Secco Vinicius Andrade , Simon Cátia Aparecida , Silva Antônio Marcos Miranda , Vendruscolo Eduardo Pradi , Andrade Maria Gabriela de Oliveira , Contardi Lucymara Merquides , de Lima Ana Paula Leite , Cordeiro Meire Aparecida Silvestrini , Abreu Mariele Silva 
Published: July 2021

Soil microbiological indicators are essential tools to understand how the management with cover crops interferes in the activity and the soil microbial community. Thus, the objective of the study was to evaluate microbiological attributes and performance of the bacterial community in the soil of the Brazilian Cerrado with different cover crops. The experiment was performed in a randomized block design, evaluating seven cover crops, Sorghum bicolor, Crotalaria ochroleuca, Pennisetum americanum, Panicum miliaceum, Raphanus sativus, Urochloa brizantha, Urochloa ruziziensis, and a fallow area. Cover aerial biomass dry weight (CB), microbial biomass carbon (MBC), basal soil respiration (BR), metabolic quotient (qCO2), and abundance and structure of bacterial community based on the rrs 16S rRNA gene were evaluated. In the soil cultivated with S. bicolor there was the highest CB and MBC at the same time as there was less microbial activity (lower BR and qCO2). The structure of the bacterial community was more differentiated in soils cultivated with S. bicolor, P. americanum, and C. ochroleuca. The MBC was more associated with cover crops of the Urochloa genus, while BR was positively correlated with S. bicolor. Bacterial abundance was positively correlated with P. miliaceum.
PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship: a retrospective sentinel network cohort study
Authors: de Lusignan Simon , Joy Mark , Sherlock Julian , Tripathy Manasa , van Hecke Oliver , Gbinigie Kome , Williams John , Butler Christopher , Hobbs FD Richard 
Published: July 2021

BackgroundThe Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE) has provided in-pandemic evidence that azithromycin and doxycycline were not beneficial in the early primary care management of coronavirus 2019 disease (COVID-19).AimTo explore the extent of in-pandemic azithromycin and doxycycline use, and the scope for trial findings impacting on practice.Design & settingCrude rates of prescribing and respiratory tract infections (RTI) in 2020 were compared with 2019, using the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC).MethodNegative binomial models were used to compare azithromycin and doxycycline prescribing, lower respiratory tract infections (LRTI), upper respiratory tract infections (URTI), and influenza-like illness (ILI) in 2020 with 2019; reporting incident rate ratios (IRR) between years, and 95% confidence intervals (95% CI).ResultsAzithromycin prescriptions increased 7% in 2020 compared with 2019, whereas doxycycline decreased by 7%. Concurrently, LRTI and URTI incidence fell by over half (58.3% and 54.4%, respectively) while ILI rose slightly (6.4%). The overall percentage of RTI-prescribed azithromycin rose from 0.51% in 2019 to 0.72% in 2020 (risk difference 0.214%; 95% CI = 0.211 to 0.217); doxycycline rose from 11.86% in 2019 to 15.79% in 2020 (risk difference 3.93%; 95% CI = 3.73 to 4.14). The adjusted IRR showed azithromycin prescribing was 22% higher in 2020 (IRR = 1.22; 95% CI = 1.19 to 1.26; P<0.0001). For every unit rise in confirmed COVID-19 there was an associated 3% rise in prescription (IRR = 1.03; 95% CI = 1.02 to 1.03; P<0.0001); whereas these measures were static for doxycycline.ConclusionPRINCIPLE demonstrates scope for improved antimicrobial stewardship during a pandemic.
Implementacja modelu kształcenia nauczycieli przedszkoli i edukacji wczesnoszkolnej w Polsce
Authors: Surma Barbara 
Published: July 2021

Reforma szkolnictwa wyższego w Polsce zmienia system i standardy kształcenia nauczycieli przedszkoli i edukacji wczesnoszkolnej. Od opublikowania w 2019 roku „Rozporządzenia Ministra Nauki i Szkolnictwa Wyższego w sprawie standardu kształcenia przygoto-wującego do wykonywania zawodu nauczyciela” (Dz.U. 2019 poz. 1450), zaczęto wprowadzać zmiany, które obejmują przeniesienie procesu kształcenia nauczycieli z systemu dwuetapowego na system jednolitych studiów magisterskich. Zmiany w systemie kształcenia zostały poprzedzone opracowaniem modelu kształcenia oraz wdrażaniem programów w ramach projektów dofinansowanych ze środków europejskich. Celem tego artykułu jest przybliżenie i ocena założeń „Propozycji modelu kształcenia nauczycieli przedszkolnych i wczesnoszkolnych” (z roku 2018) na przykładzie implementacji projektu zatytułowanego „Eksperymentalny program kształcenia nauczycieli przedszkoli i edukacji wczesnoszkolnej w Akademii Ignatianum w Krakowie” oraz wskazanie istotnych różnic między wstępnymi założeniami, które obecnie są wdrażane w formie eksperymentu na kilku uczelniach, a obowiązującymi od 2019 roku ministerialnymi wytycznymi. Po krótkim wprowadzeniu i nakreśleniu aktualnej sytuacji wskazano główne przyczyny, jakimi kierowano się w opracowaniu nowych wytycznych, które zostały ocenione. Zmiany w procesie kształcenia nauczycieli mają przyczynić się do podniesienia jakości ich przygotowania, co zostało uwzględnione w obu wspomnianych i analizowanych dokumentach.
PENENTUAN KANDUNGAN LEMAK DAN KOMPOSISI ASAM-ASAM LEMAK PADA BAGIAN BADAN IKAN GABUS (Channa striata) BUDIDAYA DAN LIAR
Authors: Umage Alvy M. , Pontoh Julius , Momuat Lidya I. 
Published: July 2021

ABSTRAK Telah dilakukan penentuan kandungan lemak dan komposisi asam-asam lemak pada bagian badan ikan gabus (Channa striata) budidaya dan liar. Penelitian ini bertujuan untuk mengetahui berapa kandungan lemak dan komposisi asam lemak pada bagian badan ikan gabus (Channa striata) budidaya dan liar. Kandungan lemak dilakukan menggunakan metode ektraksi dan diperoleh kandungan lemak bagian badan ikan gabus budidaya 0,07% dan ikan gabus liar 0,01%. Lemak ikan diderivatisasi dan dianalisis menggunakan kromatografi gas dan diperoleh komposisi asam lemak tertinggi pada bagian badan ikan gabus budidaya adalah asam lemak oleat 37,1% diikuti dan diikuti oleh asam lemak palmitat 25,6% sedangkan asam lemak tertinggi pada bagian badan ikan gabus liar adalah asam lemak palmitat 28,6% dan diikuti asam lemak oleat 16,9%. Kandungan asam lemak omega-3 pada bagian badan ikan gabus budidaya 5,6% dan ikan gabus liar 9,0%. Kata kunci: Asam lemak, ikan gabus budidaya dan liar, kromatografi gas ABSTRACT Determination of fat content and composition of fatty acids in the body of snakehead (Channa striata) from cultivated and wild sources. This study aims to determine how much fat content and composition fatty acids in the body of snakehead (Channa striata) from cultivated and wild sources. The fat content were carried out using the extraction method. The fat content of cultured snakehead body was 0.07% and that of wild fish was 0.01%. Fish fats were derivatized and analyzed using gas chromatography and the highest fatty acid composition on the body of cultivated snakehead fish is 37.1% oleic fatty acids followed by 25.6% palmitic fatty acids while the highest fatty acid in the body of a wild snakehead fish is 28.6% palmitic fatty acid and followed by 16.9% oleic fatty acid. The content of omega-3 fatty acids in the body of cultivated snakehead fish is 5.6% and 9.0% on wild snakehead fish. Keywords: Fatty acids, wild and cultivated snakehead fish, gas chromatography
UJI KUALITAS BAKASANG IKAN CAKALANG (KATSUWONUS PELAMIS) YANG ADA DI PASARAN BERDASARKAN PARAMETER FREE FATTY ACID (FFA) DAN PEROXIDE VALUE (PV)
Authors: Montolalu Gisella T. , Fatimah Feti , Kamu Vanda 
Published: July 2021

ABSTRAK Bakasang adalah produk fermentasi yang dibuat dari jeroan ikan. Telah dilakukan penelitian uji kualitas bakasang ikan cakalang (Katsuwonus pelamis) yang ada di pasaran berdasarkan parameter Free Fatty Acid (FFA) dan Peroxide value (PV). Bakasang yang digunakkan berasal dari empat tempat berbeda Sario, Tambala, Supermarket dan Karombasan. Bilangan peroksida tertinggi adalah bakasang yang dibeli di Supermarket 5,18 meq/kg dan yang terendah adalah bakasang yang dibeli di Tambala 3,88 meq/kg. Asam lemak bebas tertinggi adalah bakasang yang dibeli di Karombasan 2,13% dan yang terendah adalah bakasang yang dibeli di Sario 1,25%. ABSTRACT Bakasang is a fermented product made from fish innard. Research has been conducted of the quality of cakalang fish (Katsuwonus pelamis) on the market has been conducted based on the parameters of Free Fatty Acid (FFA) and Peroxide value (PV). Bakasang used are from four different places: Sario, Tambala, Supermarket and Karombasan. The highest peroxide number was bakasang purchased at 5.18 meq / kg Supermarket and the lowest was bakasang purchased at Tambala 3.88 meq / kg. The highest free fatty acid was bakasang which was bought in Karombasan 2.13% and the lowest was bakasang which was bought in Sario 1.25%.
SINTESIS NANOPARTIKEL COBALT FERRITE (CoFe2O4) DENGAN METODE KOPRESIPITASI DAN APLIKASINYA SEBAGAI FOTOKATALIS
Authors: Suaib Suaib , Aritonang Henry , Koleangan Harry S. J. 
Published: July 2021

ABSTRAKTelah dilakukan penelitian tentang kemampuan fotokatalis nanopartikel CoFe2O4 dalam mendegradasi zat warna sintetik Methylene Blue (MB) menggunakan metode kopresipitasi. Nanopartikel tersebut dikarakterisasi menggunakan X-Ray Diffractometry (XRD), Scanning Electron Microscope (SEM) dan spektroskopi UV-vis. Kemampuan fotokatalis dilakukan melalui penentuan konsentrasi Methylene Blue yang tersisa setelah waktu kontak nanopartikel CoFe2O4 dengan larutan Methylene Blue 5 ppm yang disinari sinar UV-A selama 30, 45, 60, 90 dan 120 menit. Penentuan konsentrasi dihitung berdasarkan absorbansi yang didapatkan dari hasil pembacaan uji Spektrofotometri UV-vis lalu digunakan rumus menghitung % degradasi. Hasil penelitian menunjukkan bahwa kemampuan fotokatalis paling baik adalah nanopartikel CoFe2O4 dengan nilai % degradasi untuk variasi waktu penyinaran 60 menit adalah sebesar 40,72 %. ABSTRACTA research on the ability of CoFe2O4 nanoparticles degradation of as photocatalyst to dyemethylene Blue(MB) synthetic using coprecipitation method. The nanoparticles were characterized using X-ray diffractometry (XRD), Scanning Electron Microscope (SEM) and UV-Vis spectroscopy. The ability of the photocatalyst is done by determining the concentration of Methylene Blue residu after contact time of CoFe2O4 nanoparticleswith a solution of Methylene Blue 5 ppm irradiated UV-A for 30, 45, 60, 90 and 120 minutes. Determining the concentration is calculated based on the absorbance obtained from the results of analysis UV-vis spectrophotometry and then used a formula calculating the% degradation. The results showed that ability is the best photocatalyst CoFe2O4 nanoparticles with the value of% degradation for variations in exposure time of 60 minutes is equal to 40.72 %.
SINTESIS NANOPARTIKEL Ag/CoFe2O4 MENGGUNAKAN EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten) Steenis) DAN APLIKASINYA SEBAGAI FOTOKATALIS UNTUK MENDEGRADASI ZAT WARNA METHYLENE BLUE
Authors: Tjiang David , Aritonang Henry F. , Koleangan Harry S. J. 
Published: July 2021

ABSTRAKTelah dilakukan penelitian tentang kemampuan fotodegradasi zat warna sintetik Methylene Blue dengan menggunakan nanopartikel Ag/CoFe2O4 dengan variasi perbandingan mol AgNO3:(Co(NO3)2.6H2O): (Fe(NO3)3.9H2O)= 0,3:0,7:2 dan jumlah ekstrak daun binahong (Anredera cordifolia (Ten) Steenis) yang ditambahkan 10 mL. Material tersebut dikarakterisasi menggunakan X-Ray Diffractometry (XRD), Scanning Electron Microscope (SEM) dan spektroskopi UV-vis. Kemampuan fotodegradasi dilakukan melalui penentuan konsentrasi Methylene Blue (konsentrasi awal 5 ppm) yang tersisa setelah berinteraksi dengan nanopartikel Ag/CoFe2O4 yang disinari sinar UV-A selama 30, 60, 120 dan 150 menit. Penentuan konsentrasi dihitung berdasarkan absorbansi yang didapatkan dari hasil pembacaan uji Spektrofotometri UV-vis, lalu digunakan rumus menghitung persen degradasi. Hasil penelitian menunjukkan bahwa yang memiliki kemampuan fotodegradasi paling baik adalah nanopartikel Ag/CoFe2O4 (0,3 : 0,7 : 2) mol dengan waktu kontak 120 menit, yaitu dengan nilai persen degradasi sebesar 44,84 %. ABSTRACTA research on photodegradation ability Methylene Blue dye synthetic by using Ag/CoFe2O4 nanoparticles with a mole ratio variation AgNO3 : (Co(NO3)2.6H2O) : (Fe(NO3)3.9H2O)= 0,3:0,7:2 and the amount of binahong (Anredera cordifolia (Ten) Steenis) leaf extract added 10 mL. These materials were characterized using X-Ray Diffractometry (XRD), Scanning Electron Microscope (SEM) and UV-vis Spectroscopy. Ability photodegradation done by determining the concentration of Methylene Blue is residue after the interaction with Ag/CoFe2O4 nanoparticles with irradiated UV-A for 30, 60, 120 and 150 minutes. Determining the concentration is calculated based on the absorbance obtained from the results of the analysis of UV-vis Spectrophotometry and then used a formula calculating the percent degradation. The results showed that the ability is best photodegradation Ag/CoFe2O4 nanoparticles (0,3: 0,7: 2) moles with a contact time of 120 minutes with a degradation value of 44.84%.