bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sperm Storage in a Family-Living Lizard, the Tree Skink (Egernia striolata)
Authors: Riley Julia L , Stow Adam , Bolton Peri E , Dennison Siobhan , Byrne Richard W , Whiting Martin J 
Published: August 2021

AbstractThe ability to produce viable offspring without recently mating, either through sperm storage or parthenogenesis, can provide fitness advantages under a suite of challenging ecological scenarios. Using genetic analysis, we demonstrate that 3 wild-caught female Tree Skinks (Egernia striolata) reproduced in captivity with no access to males for over a year, and that this is best explained by sperm storage. To the best of our knowledge, this is the first time female sperm storage has been documented in any monogamous family-living reptile, including social Australian egerniine skinks (from the subfamily Egerniinae). Furthermore, by using paternal reconstruction of genotypes we show that captive-born offspring produced by the same females in the preceding year, presumably without sperm storage, were sired by different males. We qualitatively compared aspects of these females’ mates and offspring between years. The parents of each litter were unrelated, but paternal and offspring genotypes from litters resulting from stored sperm were more heterozygous than those inferred to be from recent matings. Family-living egerniine skinks generally have low rates of multiple paternity, yet our study suggests that female sperm storage, potentially from outside social partners, offers the real possibility of benefits. Possible benefits include increasing genetic compatibility of mates and avoiding inbreeding depression via cryptic female choice. Sperm storage in Tree Skinks, a family-living lizard with a monogamous mating system, suggests that females may bet-hedge through extra-pair copulation with more heterozygous males, reinforcing the idea that females could have more control on reproductive outcomes than previously thought.
The relationship of telmisartan with sclerostin in the osteoporosis model induced by ovariectomy in rats
Authors: Kutlu Zerrin , Bilen Arzu , Celik Muhammet , Maman Adem , Gulaboglu Mine , Kul Ayhan , Celik Zeynep , Halici Zekai 
Published: August 2021

Abstract

Objectives
Our aim is to explain the relationship between Ang II and Scl in osteoporotic (OP) rats and the contribution of Scl in the antiosteoporotic effect mechanism of angiotensin receptor blockers (ARB).

Methods
This study consists of two sub-studies conducted on 4th and 12th weeks after ovariectomy. In study 1, treatment was started immediately after bilateral ovariectomy (OVX), while, in study 2, treatment was started 2 months after OVX. Two different doses of telmisartan (5 and 10 mg/kg) were administered with the aid of gavage for 30 days in both sub-study groups.

Results
Serum and tissue Scl, osteocalcin, osteopontin and tartrate-resistant acid phosphatase mRNA expressions were higher and bone mineral densities (BMD) and bone-specific alkaline phosphatase (BALP) mRNA expressions were found to be lower in the OVX groups compared with the sham group. In OVX groups where two different doses of telmisartan were administered, BMD and BALP mRNA expressions increased and serum and tissue Scl decreased.

Conclusion
There may be a close relationship between angiotensin II and sclerostin in the development of osteoporosis. In this study, telmisartan administration showed an antiosteoporotic effect and significantly decreased the level of sclerostin. These results strongly support this relationship.
Moringa oleifera: a systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity
Authors: Liu Rong , Liu Jing , Huang Qi , Liu Shao , Jiang Yueping 
Published: August 2021

Abstract

Objectives
Moringa oleifera (M. oleifera) Lam (Moringaceae) is a perennial plant broadly used in South Asia and Africa as a traditional folk medicine to treat many ailments such as paralysis, helminthiasis, sores and skin infections. The review provides a critical and comprehensive evaluation of the botany, traditional uses, phytochemistry, pharmacology, toxicity, agricultural economy and dietary benefit of M. oleifera and its future perspectives.

Key findings
In this review, the entire plant of M. oleifera, containing diverse phytochemicals, is summarized. The 163 chemical components, included flavonoids, carbamates, glucosinolates, phenols, and so on with various bioactivities, such as anti-tumour, antioxidant, anti-inflammatory, and so on. Additionally, M. oleifera is toxic at certain doses; and overuse can cause genotoxicity.

Summary
Although M. oleifera has been widely used in traditional medicine, the pharmacological studies that have been conducted so far are not sufficient for its use in the setting of evidence-based medicine. Little relevant data from clinical trials of M. oleifera have been reported. The majority of studies of its constituents, such as carbamates and glucosinolates, have been conducted only in vitro. Owing to a lack of available data, the pharmacology, toxicity, agricultural economy and dietary benefit of its constituents and extracts require further evaluation.
Plant–plant communication in variety mixtures plays on disease susceptibility and immunity
Authors: Bancal Marie-Odile 
Published: August 2021

This article comments on:Pélissier R, Buendia L, Brousse A, Temple C, Ballini E, Fort F, Violle C, Morel JB. 2021. Plant neighbour-modulated susceptibility to pathogens in intraspecific mixtures. Journal of Experimental Botany 72, 6570–6580.
Long-term stability of planets in and around binary stars
Authors: Ballantyne Harry A , Espaas Tore , Norgrove Bethan Z , Wootton Bethany A , Harris Benjamin R , Pepper Isaac L , Smith Richard D , Dommett Rosie E , Parker Richard J 
Published: August 2021

ABSTRACT
Planets are observed to orbit the component star(s) of stellar binary systems on so-called circumprimary or circumsecondary orbits, as well as around the entire binary system on so-called circumbinary orbits. Depending on the orbital parameters of the binary system, a planet will be dynamically stable if it orbits within some critical separation of the semimajor axis in the circumprimary case, or beyond some critical separation for the circumbinary case. We present N-body simulations of star-forming regions that contain populations of primordial binaries to determine the fraction of binary systems that can host stable planets at various semimajor axes, and how this fraction of stable systems evolves over time. Dynamical encounters in star-forming regions can alter the orbits of some binary systems, which can induce long-term dynamical instabilities in the planetary system and can even change the size of the habitable zone(s) of the component stars. However, the overall fraction of binaries that can host stable planetary systems is not greatly affected by either the assumed binary population or the density of the star-forming region. Instead, the critical factor in determining how many stable planetary systems exist in the Galaxy is the stellar binary fraction – the more stars that are born as singles in stellar nurseries, the higher the fraction of stable planetary systems.
Radar observations of the daytime β-Taurids and ζ-Perseids
Authors: Dewsnap R Logan , Campbell-Brown M 
Published: August 2021

ABSTRACT
We measure the activity, orbital characteristics, and mass index of the strongest daytime Taurid meteor showers (ζ-Perseids and β-Taurids) as observed by the Canadian Meteor Orbit Radar during 2002–2020. This survey recorded ∼2 × 104 stream orbits and more than 4 × 104 single-station events with speed measurements, for meteoroids with masses ${\sim }1 \times 10^{-7}{\, \mathrm{kg}}$ and sizes ${\sim }5 \times 10^{-4}\, \mathrm{m}$. ζ-Perseid activity occurred during the interval 56○ ≤ λ⊙ ≤ 92○ and peaked at λ⊙ = 77.0○, while the β-Taurids were active during the overlapping period 85○ ≤ λ⊙ ≤ 103○ and peaked at λ⊙ = 95.0○. The corrected out-of-atmosphere velocities at these activity peaks were 26.4 and 26.3 km s−1, respectively. The showers display a broad period of activity with an asymmetric profile, with a gradual increase at the beginning and a sharper decrease after the peak. The mass indices of the ζ-Perseids and β-Taurids during their periods of activity were found to be 1.81 ± 0.05 and 1.87 ± 0.05, with the ζ-Perseids reaching a minimum of 1.71 ± 0.05 around the peak of activity.
Observations of cold gas and star formation in dwarf S0 galaxies
Authors: Ge Xue , Gu Qiu-Sheng , García-Benito Rubén , Lu Shi-Ying , Lei Cheng-Long , Ding Nan 
Published: August 2021

ABSTRACT
Very little work has been done on star formation in dwarf lenticular galaxies (S0s). We present 2D spectroscopic and millimetre observations made by the Centro Astronómico Hispano Alemán (CAHA) 3.5-m optical and Institut de Radioastronomie Millimétrique (IRAM) 30-m millimetre telescopes, respectively, for a sample of four dwarf S0 galaxies with multiple star formation regions in the field environment. We find that, although most of the sources deviate from the star-forming main-sequence relation, they all follow the Kennicutt–Schmidt law. After comparing the stellar and Hα kinematics, we find that the velocity fields of both stars and ionized gas show no regular motion and the velocity dispersions of both stars and ionized gas are low in regions with high star formation, suggesting that these star-forming S0 galaxies still have significant rotation. This view can be supported by the result that most of these dwarf S0 galaxies are classified as fast rotators. The ratio of the average atomic gas mass to stellar mass ($\sim 47{{\ \rm per\ cent}}$) is much greater than that of the molecular gas mass to stellar mass ($\sim 1{{\ \rm per\ cent}}$). In addition, gas-phase metallicities in star-forming regions are lower than those of non-star-forming regions. These results indicate that extended star formation may originate from the combination of abundant atomic hydrogen, a long dynamic time-scale, and a low-density environment.
Effects of dark matter on the in-spiral properties of the binary neutron stars
Authors: Das H C , Kumar Ankit , Patra S K 
Published: August 2021

ABSTRACT
Using the relativistic mean-field model, we calculate the properties of binary neutron star (BNS) in the in-spiral phase. Assuming the dark matter (DM) particles are accreted inside the neutron star (NS) due to its enormous gravitational field, the mass M, radius R, tidal deformability λ, and dimensionless tidal deformability Λ are calculated at different DM fractions. The value of M, R, λ, and Λ decreases with the increase of DM percentage inside the NS. The in-spiral phase properties of the BNS are explored within the post-Newtonian (PN) formalism, as it is suitable up to the last orbits in the in-spiral phase. We calculate the strain amplitude of the polarization waveform h+ and h×, (2,2) mode waveform h22, orbital phase Φ, frequency of the gravitational wave f, and PN parameter x with DM as an extra candidate inside the NS. The magnitude of f, Φ, and x are almost the same for all assumed forces; however, the in-spiral time duration in the last orbit is different. We find that the BNS with soft equation of state and a high fraction of DM sustains more time in their in-spiral phase. We suggest that one should take DM inside the NS when they modelling the in-spiral waveforms for the BNS systems.
Intermediate-mass black holes from stellar mergers in young star clusters
Authors: Di Carlo Ugo N , Mapelli Michela , Pasquato Mario , Rastello Sara , Ballone Alessandro , Dall’Amico Marco , Giacobbo Nicola , Iorio Giuliano , Spera Mario , Torniamenti Stefano , Haardt Francesco 
Published: August 2021

ABSTRACTIntermediate-mass black holes (IMBHs) in the mass range $10^2\!-\!10^5\, \mathrm{M_{\odot }}$ bridge the gap between stellar black holes (BHs) and supermassive BHs. Here, we investigate the possibility that IMBHs form in young star clusters via runaway collisions and BH mergers. We analyse 104 simulations of dense young star clusters, featuring up-to-date stellar wind models and prescriptions for core collapse and (pulsational) pair instability. In our simulations, only nine IMBHs out of 218 form via binary BH mergers, with a mass ∼100–140 M⊙. This channel is strongly suppressed by the low escape velocity of our star clusters. In contrast, IMBHs with masses up to ∼438 M⊙ efficiently form via runaway stellar collisions, especially at low metallicity. Up to ∼0.2 per cent of all the simulated BHs are IMBHs, depending on progenitor’s metallicity. The runaway formation channel is strongly suppressed in metal-rich (Z = 0.02) star clusters, because of stellar winds. IMBHs are extremely efficient in pairing with other BHs: ∼70 per cent of them are members of a binary BH at the end of the simulations. However, we do not find any IMBH–BH merger. More massive star clusters are more efficient in forming IMBHs: ∼8 per cent (∼1 per cent) of the simulated clusters with initial mass 104–3 × 104 M⊙ (103–5 × 103 M⊙) host at least one IMBH.
The Oldest Co-opted gag Gene of a Human Endogenous Retrovirus Shows Placenta-Specific Expression and Is Upregulated in Diffuse Large B-Cell Lymphomas
Authors: Boso Guney , Fleck Katherine , Carley Samuel , Liu Qingping , Buckler-White Alicia , Kozak Christine A 
Published: August 2021

Abstract
Vertebrate genomes contain endogenous retroviruses (ERVs) that represent remnants of past germline infections by ancient retroviruses. Despite comprising 8% of the human genome, the human ERVs (HERVs) do not encode a replication competent retrovirus. However, some HERV genes have been co-opted to serve host functions, most notably the viral envelope-derived syncytins involved in placentation. Here, we identify the oldest HERV intact gag gene with an open reading frame, gagV1. Its provirus contains an intact env, envV1, and the first open reading frame found in an HERV gag leader, pre-gagV1, which encodes a novel protein. This HERV is linked to a related gag gene, gagV3, and these three genes all show patterns of evolutionary conservation in primates. gagV1 and pre-gagV1 orthologs are present in all simian primate lineages indicating that this HERV entered the germline of the common simian primate ancestor at least 43 Ma, whereas gagV3 is found in Old and New World monkeys. gagV1 and gagV3 have undergone recurrent gene conversion events and positive selection. Expression of gagV1, gagV3, and pre-gagV1 is restricted to the placenta in humans and macaques suggesting co-option for placenta-specific host functions. Transcriptomic analysis of human tumors also found upregulated levels of gagV1 transcripts in diffuse large B-cell lymphomas. These findings suggest that these HERV-V genes may be useful markers for the most common type of non-Hodgkin’s lymphoma and that they may have contributed to the successive domestications of env and gag genes in eutherians involved in the ongoing ERV-driven evolution of the placenta.
HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis
Authors: Yan Bowen , Yang Jennifer , Kim Min Young , Luo Huacheng , Cesari Nicholas , Yang Tao , Strouboulis John , Zhang Jiwang , Hardison Ross , Huang Suming , Qiu Yi 
Published: August 2021

Abstract
The activity of hematopoietic factor GATA-1 is modulated through p300/CBP-mediated acetylation and FOG-1 mediated indirect interaction with HDAC1/2 containing NuRD complex. Although GATA-1 acetylation is implicated in GATA-1 activation, the role of deacetylation is not studied. Here, we found that the FOG-1/NuRD does not deacetylate GATA-1. However, HDAC1/2 can directly bind and deacetylate GATA-1. Two arginine residues within the GATA-1 linker region mediates direct interaction with HDAC1. The arginine to alanine mutation (2RA) blocks GATA-1 deacetylation and fails to induce erythroid differentiation. Gene expression profiling and ChIP-seq analysis further demonstrate the importance of GATA-1 deacetylation for gene activation and chromatin recruitment. GATA-12RA knock-in (KI) mice suffer mild anemia and thrombocytopenia with accumulation of immature erythrocytes and megakaryocytes in bone marrow and spleen. Single cell RNA-seq analysis of Lin− cKit+ (LK) cells further reveal a profound change in cell subpopulations and signature gene expression patterns in HSC, myeloid progenitors, and erythroid/megakaryocyte clusters in KI mice. Thus, GATA-1 deacetylation and its interaction with HDAC1 modulates GATA-1 chromatin binding and transcriptional activity that control erythroid/megakaryocyte commitment and differentiation.
A Righteous Consensus, Whig Style
Authors: Marsden George M. 
Published: August 2021

Abstract
Various Protestant denominations founded hundreds of colleges during the first half of the nineteenth century. Even two-thirds of presidents of state universities were clergymen. Though those in the Reformed tradition tended to be the leading educators, denominational diversity and necessities of attracting varieties of students weakened doctrinal distinctives. The prevailing “Whig” ideal emphasized combining building a modern civilization with Christian morality. Educators, such as Francis Wayland or Mark Hopkins, confidently assumed that the best of objective common sense and modern science would support traditional Christianity. Colleges still promoted the evangelical tradition, as in campus revivals. They taught the classics as a way of developing moral faculties, as the Yale Report of 1828 advocated. Specifically Christian perspectives were found in capstone moral philosophy courses.
Daniel Coit Gilman and the Model for a Modern University
Authors: Marsden George M. 
Published: August 2021

Abstract
Daniel Coit Gilman became the founding president of The Johns Hopkins University in 1876. There he established what became the model for modern American universities. Gilman had similar New England roots to other major university leaders. His first experience of leadership was at the University of California. That university started in Berkeley in 1868 when a Presbyterian college, the College of California, ceded itself to the state. Gilman had to negotiate the tensions between being an inclusive state university while having a distinct denominational heritage. The New Johns Hopkins University was accused of being atheistic, but Gilman instituted voluntary chapel and showed concern for including Christian dimensions in the undergraduate curriculum. Following the German model though, he made original scholarship and graduate education the marks of a true university. While not anti-religious, intellectual inquiry was expected to adopt standards that might be called “methodological naturalism.”
Harvard and the Religion of Humanity
Authors: Marsden George M. 
Published: August 2021

Abstract
Under the leadership of Charles W. Eliot, Harvard set the pace in moving from an old-time college in the mid-1800s to a leading modern university by the early 1900s. Eliot was known for instituting the elective system. Influenced by German ideals, he emphasized modern education as inculcating freedom and building character. He said the university could not be founded upon a sect but must serve the whole nation. He was also an advocate of the modern expert. William James became the best known of Harvard’s impressive faculty. His pragmatic search for religious expression well represented the spirit of search for nonsectarian spirituality and morality. Charles Eliot Norton championed the idea of the humanities as the source for finding the highest human ideals.
Orthodoxy at the Gentlemen’s Club
Authors: Marsden George M. 
Published: August 2021

Abstract
Princeton, with its Old School Presbyterian heritage, had stronger sectarian theological ties than other leading schools. President James McCosh, an accomplished Scottish philosopher, helped modernize the college while still keeping a strong religious presence. In famous debates with Charles Eliot in the 1880s, he argued that freedom always works within limits. His successor, Francis Patton, was rigorously conservative in his Presbyterian orthodoxy but ran Princeton very much as a gentlemen’s club. Woodrow Wilson as president helped professionalize the university but remained loyal to broad Christian ideals. As at other schools of the era, the most vigorous religious expressions were in student voluntary associations.
The Federal Republic of Germany
Authors: Calabresi Steven Gow 
Published: August 2021

Abstract
This chapter looks at the German system of judicial review of the constitutionality of legislation, which has been borrowed by virtually all of the civil law countries in the world as being the one that is the most compatible with their legal system. The historical lessons drawn from Germany’s experience with the Third Reich made Germans acutely aware of the need for constitutional protection of rights growing out of the great historical wrongs of Nazism and of the Holocaust. Thus, the fundamental core explanation of the origins and growth of German judicial review is that it is a rights from wrongs phenomenon. That being said, the growth of German judicial review was made easier by the fact that the German Basic Law constituted the Constitutional Court to act as a federalism and separation of powers umpire. The German Constitutional Court has performed those umpiring function from 1949 down to the present day with great deftness and ability. Thanks to the great scholar, Hans Kelsen, the Germans borrowed a greatly modified system of U.S. judicial review, which was specially designed to work well in civil law countries. The German Model has, in turn, been borrowed by every oother country discussed in Volume II of my two part book series.
The Republic of Italy
Authors: Calabresi Steven Gow 
Published: August 2021

Abstract
This chapter looks at Italian judicial review and the Italian Constitution’s Bill of Rights. The Italian Bill of Rights and Italian judicial review emerged primarily as the result of a rights from wrongs process. This is shown by the Italian Constitutional Court’s first case in which it overturned an Italian Fascist-era law forbidding the distribution of political pamphlets. Moreover, judicial review has thrived in Italy because, unlike Japan, the Italian Constitution sets up a variety of different competing power centers among which the Constitutional Court can navigate to get its way. Meanwhile, the complex Italian political party systems in the last sixty years may have allowed the Italian Constitutional Court more freedom to navigate the Italian political process for the same reason that radical proportional representation in Israel helped Aharon Barak in cementing in place Israeli constitutionalism. Finally, Italy’s multiparty system may have caused alliances on the left and on the right to constitutionalize rights for “insurance and commitment” reasons.
The Effect of Incentives
Authors: Brennan Jason , English William , Hasnas John , Jaworski Peter 
Published: August 2021

Abstract
Every business faces internal conflicts of interest. They must determine how to motivate employees to cooperate in a productive manner, while also limiting the temptation to exploit the business for private gain. Designing good incentives is essential. If inputs are easy to measure, employees can be compensated based on how much work they do, but if inputs are hard to measure, it may be more effective to tie compensation to a firm’s output in the form of stock options and profit-sharing. However, care must be taken to ensure that executives do not misrepresent the value of the company or engage in fraud in order to inflate stock prices. Compensation packages that lengthen the vesting period of stock options and allow ill-gotten gains to be clawed back, as well as whistleblower programs that reward those who expose fraud, can help prevent bad behavior and ensure that business leaders focus on genuine productivity.