bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Time-Dependent Dynamics of Gut Microbiota and the Interaction With Host Metabolism in Mouse Pulmonary Fibrosis Models
Authors: Yang Xiao-Hui , Jia Xiu-Juan , Chi Xiao-Sa , Wang Xiao-Meng , Wang Fang-Fang , Cong Jin-Peng , Wei Hong-Yun , Zheng Hui , Zhang Yu-Zhu 
Published: September 2021

Abstract
Background: Pulmonary fibrosis (PF) is a chronic progressive disease whose pathogenesis is thought to be associated with activation of the immune system and consequent metabolic changes. Recent studies suggested that gut microbes are closely related with host's immune response and metabolic changes in fibrotic hosts. However, the dynamic changes of the gut microbiome and the interaction profiles with host metabolism during the development of pulmonary fibrosis remain inconclusive. Results: We collected serum and fecal samples from bleomycin-induced fibrotic mice at 0, 7, 14, and 28 days and performed UPLC-MS analysis on serum metabolites and metagenomic sequencing on fecal samples. It is found that the serum metabolic profile and gut microbiome were significantly altered in mice during the progression of fibrosis. Among the serum metabolites, the levels of three major types of lipids, i.e., glycerolipids, glycerophospholipids, and fatty acids exhibit significant time-dependent changes. The glycerolipid TG and multiple glycerophospholipids (3 PG, 6 PE, and 1 PC) decreased in the early stage of fibrosis and increased in the late stage. The other two types of glycerolipids MG and DG and the fatty acids Cartinine and Punicic acid decreased through the development of fibrosis. In the meantime, we detected significantly elevated abundance of gut microbiome taxa, including Prevotella sp. from Bacteroidetes, Lactobacillus from Firmicutes, and Bifidobacterium from Actinobacteria in mice with pulmonary fibrosis. When compared to the dynamic profiles of serum metabolites, the abundances of gut microbiome show a high level of correlation with that of serum metabolites. The taxa from Bacteroides, such as Butyricimonas_synergistica and Muribaculaceae, show positive correlation with the cluster of glycerophospholipids, while taxa from Firmicutes, such as Clostridioides difficile and Enterococcus faecium exhibit negative correlation. Further functional classification suggested that those taxa are involved in multiple functional modules, such as Transporters, Secretion system, and Metabolism. Conclusions: The results reveal the synergistic changes between the gut microbiome and host metabolism and the dynamic responses of gut microbiome to host fibrosis during the progression of fibrosis.
Stacking of Pup1 QTL for Low Soil Phosphorus Tolerance and Bacterial Blight Resistance Genes in the Background of APMS6B, the Maintainer Line of Rice Hybrid DRRH-3
Authors: N Madhusudan , P Beulah , JALDHANI VEERENDRA , P Nagaraju , Y Manasa , RM Sundaram , GS Laha , AS HariPrasad , MS Anantha , KB Kemparaju , C Gireesh , R Gobinath , Barbadikar Kalyani M , P Brajendra , Tuti  , R Mahender Kumar , P SENGUTTUVEL 
Published: September 2021

Abstract
Phosphorus (P) is one of the macro nutrients essential for plant growth and development. Rice (Oryza sativa L.) is sensitive to P starvation and its deficiency influences many key plant functions which results in crop yield penalty. Although the hybrid rice segment is well-known for its yield heterosis, P deficiency and bacterial leaf blight (BLB) diseases are the evident limitations. APMS6B, the female parent of DRRH-3 is susceptible to low P and bacterial blight disease. In the present study, the improvement of APMS6B to P starvation and resistance to bacterial leaf blight (BB) was carried out using marker-assisted backcross breeding (MABB) approach. Kasalath (+ Pup1 QTL) was used as donor and a promising IL (ATR 594-1) at BC1 F4 generation was identified with 81.15% RPGR. Concurrently, this IL was intercrossed with GU-2 (+ Xa21 and Xa38 ). Hybridity of Intercross F1s (ICF1) was confirmed through foreground selection having maximum RPGR (88.29%) and were selfed to produce ICF2. The resultant progenies were phenotyped for BB using Xoo inoculum (IX-020), simultaneously genotyped with gene specific functional SSR markers for Xa21 and Xa38. The identified BB resistant plants were subjected to foreground selection for Pup1. Four promising ICF3 plants (BP-10-1, BP-10-3, BP-10-5 and BP-10-15 with Xa21, Xa38 and Pup1) along with parents and checks were screened both in low P plot (<2 kg P2O5 ha-1 ) as well as in normal plot (>25 kg P2O5 ha-1) during dry and wet seasons 2018. Based on the field evaluation, four promising intercrossed lines were identified with better root architecture in terms of root length and root volume. In addition, less % reduction in grain yield (39.10%) under P starvation and less susceptibility indices values (<1) for BB were observed. These lines may be utilized in the CMS conversion programme and development of climate resilient, biotic and abiotic tolerant rice hybrids.
PTK2 Promotes Uveal Melanoma Metastasis by Activating Epithelial-to-Mesenchymal Transition
Authors: Fan Zhongyi , Duan Jingjing , Zhang Lei , Chen Qiong , Xiao Wen , Luo Pu , Shao Ling , Meng Jingye , An Jianghong , Zhang Gengwei , Tan Xiaohua 
Published: September 2021

Abstract
Background: Uveal melanoma (UM) is an aggressive primary intraocular tumor in adults, with high metastatic capacity and high morbidity. However, the mechanisms of UM metastasis have not been clearly elucidated.Methods: The PTK2 expression and activation were performed in the Cancer Genome Atlas (TCGA) database and 25 patients of UM. The role of PTK2 in promoting metastasis was explored in vitro and in vivo. Subsequently, we revealed the correlation between PTK2 expression and epithelial-to-mesenchymal transition (EMT). Finally, we explored the reason for the high expression of PTK2 in UM.Results: Our study found that protein tyrosine kinase 2 (PTK2) was overexpressed in UM specimens, and as a novel independent risk factor, its overexpression predicted the poor survival of UM patients. For the molecular mechanism, PTK2 promoted EMT phenotype, thus leading to tumor metastasis in UM cells. Subsequently, we have demonstrated that PTK2 was a functional gene of chromosome 8q gain accounting for UM metastasis, providing a novel molecular mechanism for the aberrantly expression and activation of PTK2 in UM.Conclusion: Our data reveal the important role and mechanism of PTK2 in the metastatic process of UM, which may clue to a new predictive biomarker for UM metastasis and a new therapeutic target for UM treatment.
Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis
Authors: Dong Bingzi , Hiasa Masahiro , Endo Itsuro , Ohnishi Yukiyo , Kondo Takeshi , Takashi Yuichi , Tsoumpra Maria , Kainuma Risa , Sawatsubashi Shun , Kiyonari Hiroshi , Shioi Go , Sakaue Hiroshi , Nakashima Tomoki , kato shigeaki , Abe Masahiro , Fukumoto Seiji , Matsumoto Toshio 
Published: September 2021

Abstract
Exercise offers mechanical loading to the bone, while it stimulates energy expenditure in the adipose tissue. Thus, bone may secrete a factor to communicate with adipose tissue in response to mechanical loading. Interleukin (IL)-11 is expressed in the bone, upregulated by mechanical loading, enhances osteogenesis and suppresses adipogenesis. Systemic IL-11 deletion (IL-11−/−) exhibited reduced bone mass, suppressed bone formation response to mechanical loading, enhanced expression of Wnt inhibitors, and suppressed Wnt signaling. Enhancement of bone resorption under mechanical unloading was unaffected. Unexpectedly, IL-11−/− mice showed increased systemic adiposity and glucose intolerance. Osteoblast/osteocyte-specific IL-11 deletion in osteocalcin-Cre;IL-11fl/fl mice showed reduced serum IL-11, blunted bone formation under mechanical loading, and increased systemic adiposity similar to IL-11−/− mice. Adipocyte-specific IL-11 deletion in adiponectin-Cre; IL-11fl/fl mice exhibited no abnormality. Thus, IL-11 from osteoblast/osteocyte controls both osteogenesis and systemic adiposity in response to mechanical loading. These findings may bring new therapeutic approaches to osteoporosis and metabolic syndrome.
The Saviour of a Pregnant Woman With Fulminant Myocarditis ——Extracorporeal Membrane Oxygenation: A Case Report
Authors: Lin Yanan , Wang Bin , Lin Xu , Ma Fuguo , Niu Zhaozhuo , Hu Dan , Tao Hong , Weng Zhanping , Wang Mingshan , Sun Lixin , Han Wei , Bi Yanlin 
Published: September 2021

Abstract
INTRODUCTION: There are no reports regarding a pregnant woman with fulminant myocarditis underwent Extracorporeal Membrane Oxygenation (ECMO). Hence, we report a case of successful ECMO treatment of fulminant myocarditis puerpera. CASE PRESENTATION: A 32-year-old puerpera was admitted to our hospital with menopause for 7 months, fetal movement for 3 months and fever for 1 day. After admission, the patient's body temperature increased repeatedly, heart rate increased, and the whole process C-reactive protein increased rapidly. Considered a diagnosis of fulminant myocarditis. After antiviral and cardioprotective treatment, the heart function progressively worsened. Pregnancy was terminated, the newborn was intubated in the neonatal room for rescue after surgery, and ECMO treatment was given after the puerpera was transferred to the intensive care unit. Finally, the patient and the baby have been safely discharged from hospital. DISCUSSION: ECMO can provide cardiac and respiratory support. Fulminant myocarditis is common in children, adolescents and particularly pregnant women who had the highest mortality rate. In the pregnant woman with fulminant myocarditis described in this report, antiviral treatment only transiently improved heart function and then heart function progressively worsened. After receiving ECMO therapy, the patient's cardiac function has improved markedly. The patient was then successfully weaned from ECMO. To our knowledge, this is the first report of pregnant woman in whom ECMO was part of the treatment for fulminant myocarditis. CONCLUSION: We report a case of successful ECMO treatment of fulminant myocarditis puerpera. ECMO can be the treatment of choice for pregnant women with fulminant myocarditis.
Respiratory Muscle Dysfunction in COVID-19 Patients with Persistent Symptoms
Authors: Hennigs Jan K. , Huwe Marie , Hennigs Annette , Oqueka Tim , Simon Marcel , Harbaum Lars , Körbelin Jakob , Schmiedel Stefan , Wiesch Julian Schulze zur , Addo Marylyn M. , Kluge Stefan , Klose Hans 
Published: September 2021

Abstract
In a cross-sectional analysis, we have identified a high prevalence of respiratory muscle dysfunction in persistently symptomatic patients after COVID-19 (‘Long COVID’). Respiratory muscle impairment in these patients was associated with exercise-induced deoxygenation, impaired exercise tolerance, activity and functional outcomes after COVID-19.
Machine learning for Drug-Virus Prediction
Authors: Besharatifard Milad , Gharagozlou Arshia 
Published: September 2021

Abstract
The 2019 Coronavirus (COVID-19) epidemic has recently hit most countries hard. Therefore, many researchers around the world are looking for a way to control this virus. Examining existing medications and using them to prevent this epidemic can be helpful. Drug repositioning solutions can be effective because designing and discovering a drug can be very time-consuming. In this study, we used a binary classifier learning method to predict the drug-virus relationship. The feature vector for each drug-virus pair is based on the similarity between drugs and the similarity between viruses. We calculated the similarities between the drugs using their structural properties (fingerprint) and their phenotype. We also calculated the similarities between viruses based on their genome sequence and the vector encoded by the Biobert model. Finally, using the HDVD dataset, we formed the similarity vectors of each drug-virus pair and considered it as input to neural network and random forest models. In these models, we randomly selected 20% of the positive data and the same amount of negative data. Finally, the performance of the proposed approach for this test data is considered, after five tests, as AUC=0.97 and AUPR = 0.96. We also used the Compressed Sensing (CS) matrix factorization model to predict the drug-virus association. We also investigated the importance of drug features in predicting drug-virus association by using Autoencoder and reducing the dimension of drug properties.
Financial Structure, Cycle, and Instability
Authors: Ninomiya Kenshiro 
Published: September 2021

Abstract
The subprime loan mortgage crisis has revived scholarly interest in Minsky’s financial instability hypothesis. The related mathematical models present two types of Minskian financial structures. We construct macrodynamic models that consider both structures and discuss financial instability and cycles. We also demonstrate that one of the financial cycles occurs when a real factor stabilizes the economy. The burden of interest-bearing debt is an important determinant of the cycle. We posit that the escalating financial fragility in this cycle is a more appropriate interpretation of the Minskian financial structure that refers to hedging, speculative and Ponzi behaviors. We further demonstrate that another financial structure destabilizes the economy. If the instability occurs at the point of fragility, then the economy may deteriorate into financial crisis. Fragility then becomes instability.JEL classifications: E12, E32, E33, E43
Globalisation and Economic Growth in West Africa
Authors: Wanger Benjamin , Aras Osman Nuri 
Published: September 2021

Abstract
Economic integration among countries could be beneficial to trading partners if properly handled through appropriate regulation of production, distribution, and consumption. However, it appears developing countries often do not benefit from their relations with other countries at advanced stages of developed. It is in view of this that this research was conducted with concentration on West Africa. Panel Cointegration techniques including Fully Modified Ordinary Least Squares, Dynamic Ordinary Least Squares and Dumitrescu-Hurlin Panel Causality Test were applied using time series on Gross Domestic Product, Exports, Imports and Foreign Direct Investment of eight West African countries from 1960 – 2019. while a positive and significant long run causal relationship was found between Exports, Imports as aspects of globalisation and Gross Domestic Product, there was an observed negative long run relationship between Foreign Direct Investment and Gross Domestic Product. Export promotion, hight import tariffs, the local content initiative, liberal migration policies and strong regulatory machinery were recommended.JEL Codes: FGHO
Maternal Engineered Nanomaterial Inhalation During Gestation Drives Redox Dysregulation and Vascular Dysfunction Across Generations
Authors: Bowdridge Elizabeth C , DeVallance Evan , Garner Krista L , Griffith Julie A , Schafner Kallie , Seman Madison , Engels Kevin J , Wix Kimberly , Batchelor Thomas P , Goldsmith William T , Hussain Salik , Nurkiewicz Timothy R 
Published: September 2021

Abstract
Background

Pregnancy is associated with many rapid biological adaptations that support healthy development of the growing fetus. One of which is critical to fetal health and development is the coordination between maternal liver derived substrates and vascular delivery. This crucial adaptation can be potentially derailed by inhalation of toxicants. Engineered nanomaterials (ENM) are commonly used in household and industrial products as well as in medicinal applications. As such, the potential risk of exposure remains a concern, especially during pregnancy. We have previously reported that ENM inhalation leads to upregulation in the production of oxidative species. Therefore, we aimed to determine if maternal nano-TiO2 inhalation exposure resulted in altered H2O2 production capacity and changes in downstream redox pathways. Additionally, we investigated whether this persisted into adulthood within the F1 generation and how this impacted F1 gestational outcomes and F2 fetal health and development. We hypothesized that maternal nano-TiO2 inhalation exposure during gestation would result in upregulated H2O2 in the F0 dams as well as her F1 offspring, resulting in gestational vascular dysfunction in the F1 dams yielding smaller F2 generation pups.
Results

Our results indicate upregulation of hepatic H2O2 production capacity in F0 dams, F1 offspring at 8 weeks and F1 females at gestational day 20. H2O2 production capacity was accompanied by a 2-fold increase in phosphorylation of the redox sensitive transcription factor NF-κB. In cell culture, naïve hepatocytes exposed to F1-nano-TiO2 plasma increased H2O2 production. Overnight exposure of these hepatocytes to F1 plasma increased H2O2 production capacity in a partially NF- κB dependent manner. Pregnant F1- nano-TiO2 females exhibited estrogen disruption (29.81 ± 8.8 pg/ml vs. 12.12 ± 3.1 pg/ml sham-control) and vascular dysfunction similar to their directly exposed mothers. F1-nano-TiO2 uterine artery H2O2 production capacity was also elevated 2-fold. Dysfunctional gestational outcomes in the F1-nano-TiO2 dams resulted in smaller F2 pups (4.93 ± 0.47 g vs. 5.78 ± 0.09 g sham-control pups).
Conclusion

In conclusion, this manuscript provides critical evidence of redox dysregulation across generations following maternal ENM inhalation. Furthermore, the dysfunctional gestational outcomes observed in the F1-nano-TiO2 generation impact the development of F2 offspring. In total, this data provides strong initial evidence that maternal ENM exposure has robust biological impacts that persists in at least two generations.
Prevalence of Cerebrovascular Accidents in Patients with Ulcerative Colitis in a Single Academic Health System
Authors: Horta Erika , Burke-Smith Conor , Megna Bryant , Nichols Kendall , Vaughn Byron , Reshi Rwoof , Shmidt Eugenia 
Published: September 2021

Abstract
Background:In general, IBD increases arteriovenous thromboembolic events, though the association between UC and cerebrovascular complications remains inconclusive. Some studies suggest young women with UC have an increased risk of cerebrovascular accidents (CVA). The focus of this study was to characterize the rates, anatomic locations and risk factors for CVA in patients with UC. Methods:We developed a retrospective cohort of patients with UC at a single health care system from June 2010 to June 2015. Neuroimaging was used to document presence, location and type of stroke and traditional risk factors were considered. Results:The prevalence of CVAs increased in both sexes with a peak prevalence of 24.7% (95% CI 17.1 - 34.4) in women with UC over the age of 80. Older age, cancer and atrial fibrillation were risk factors for CVA in univariate analysis for both sexes. In multifactorial analysis, both age and atrial fibrillation were risk factors for CVA in the m-UC cohort, but only age was associated with CVA in f-UC. The most common type of CVA was ischemic stroke (77.7%). The most common locations for CVAs in UC patients were frontal and occipital lobes (19% and 18%, respectively). Conclusions:UC patients have an increased risk for CVA, with women over 80 demonstrating the highest risk. Providers should be aware of these risks in making treatment decisions for UC.
Identifying Performance Factors of Long-Term Care Facilities in the Context of the COVID-19 Pandemic: A Scoping Review Protocol
Authors: Létourneau Josiane , Bélanger Emilie , Sia Drissa , Beogo Idrissa , Robins Stephanie , Kruglova Katya , Jubinville Maripier , Nguemeleu Eric Tchouaket 
Published: September 2021

Abstract
Background: Long-term care facilities (LTCFs) in many countries around the world have been severely affected by the COVID-19 pandemic, leading to serious consequences for the elderly living in these facilities. Though many LTCFs experienced high case and death rates due to COVID-19, other facilities performed better, and experienced lower rates. A comprehensive understanding of performance factors affecting the transmission of COVID-19 within LTCFs is still lacking, as no published review has provided a complete perspective of LTCF management utilizing a multifactorial conceptual framework to evaluate performance during the pandemic. Recent research has consisted of strategies for infection prevention and control or studies reporting specific outcomes such as COVID-19 case and death rates within LTCFs. To address these gaps, this scoping review will identify and investigate performance factors that have affected the management of the COVID-19 pandemic in LTCFs using a multifactorial conceptual framework of performance. Methods: The CINAHL, MEDLINE (Ovid), CAIRN, Science Direct, and Web of Science databases will be searched. Included articles will have been published in a peer-reviewed journal, in English or French, between January 1st, 2020, and December 31st, 2021. They will discuss the review’s population (LTCFs), concept (dimensions of performance according to a modified version of the Ministère de la santé et des services sociaux du Québec conceptual framework), and context (COVID-19), as well as facilitators and barriers affecting performance of LTCFs. Each article will be screened by a minimum of two authors in an independent manner, after which the data from selected articles will be extracted by one author and then reviewed by the principal investigator. Results: The results will be presented both narratively and with visual aids (i.e., flowcharts, tables, conceptual maps). Discussion: A comprehensive understanding of the factors affecting performance within LTCFs could lead to improved infection prevention and control measures for the rest of the COVID-19 pandemic and assist in the proper management of future pandemics or infection outbreaks. Information on this topic could therefore lead to an improvement in the care and security of LTCF residents and personnel.Registration: Research Registry ID: researchregistry7026
Morphological and Phylogenetic Reevaluation of the Genera Mycobonia and Pseudofavolus (Polyporaceae)
Authors: Palacio Melissa , Westphalen Mauro , Yuan Yuan , Wu Yingda , Silveira Rosa Mara Borges Da 
Published: September 2021

Abstract
Mycobonia and Pseudofavolus (Polyporales, Basidiomycota) are polyporoid genera with tropical and subtropical distribution. Both genera are morphologically similar in presenting flabelliform to conchate subsessile basidiomata, with a dimitic hyphal system, consisting of clamped generative hyphae and skeleto-binding hyphae that produce large basidiospores with smooth, thin walls. However, while Pseudofavolus species present a poroid hymenophore, in Mycobonia it is stereoid with hyphal pegs that resemble thin teeth. Mycobonia and Pseudofavolus have a controversial taxonomy, and the phylogenetic relationships between their species have yet to be assessed. For this reason, we performed molecular phylogenetic analyses on specimens of Mycobonia and Pseudofavolus from both the Neotropics and Asia, using internal transcribed spacers (ITS), the large subunit of nuclear rDNA (nc LSU rDNA), and also the genes encoding the second largest subunit of RNA polymerase II (RPB2). Furthermore, in order to develop an evolutionary analysis of the hymenophore configuration, we performed stochastic character mapping of ancestral states for the hymenophore type presented in Polyporus s.l. Our study revealed that Pseudofavolus is an artificial group and its species actually nest in a clade within Mycobonia. Therefore, in order to establish a monophyletic group, based upon priority of publication, we re-circunscribed Mycobonia to encompass both stereoid and poroid hymenophore species. Two new combinations are presented from the Neotropics: Mycobonia cucullata and M. miquelii. A new species from tropical Asia, M. yuchengii, is also described. We presente a summary of stochastic mapping of ancestral states estimates of hymenophore type in Polyporus s.l. The ancestral state for Mycobonia clade is estimated to have angular pores.