bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Motion of Single and Twin Oblique Particle Clouds in Stagnant Water
Authors: Janati Mahsa , Azimi Amir Hossein 
Published: May 2021

Abstract
The evolution of single and twin oblique particle clouds in stagnant water was investigated using a series of laboratory experiments and the effects of controlling parameters such as sand mass and nozzle spacing were studied. The time variations of particle cloud properties such as frontal position, horizontal and vertical centroids, cloud width, and frontal velocity were measured using image analysis and particle image velocimetry (PIV) techniques. The entrainment coefficients were extracted from the measurements. It was found that the main vortex motion of the frontal heads altered after the collision and a new integrated frontal head was formed. The effects of release angle and particle interactions were studied by comparing the time histories of maximum centerline velocities. It was found that the centerline velocity of twin oblique particle clouds in comparison with twin vertical particle clouds increased with increasing nozzle spacing. The time history of the ratio of horizontal to vertical centroids in oblique particle clouds determined the potential location of sand particles and a practical model was developed to determine the size and location of particle clouds with time. The time histories of normalized cloud width indicated a significant change after the frontal head collision. The particle interactions due to frontal head collision in twin oblique particle clouds significantly increased the cloud width until particle clouds reached the swarm phase. The time at which twin oblique particle clouds reached the swarm phase was recorded and a linear model was proposed to link the time to reach the swarm phase with the cloud aspect ratio and nozzle spacing.
Acoustic Waves Radiated From Two Degrees-of-Freedom Nonlinear Rigid Oscillator Systems Immersed in Unbounded Compressible Fluid
Authors: Zhang Junxian , Xie Fangtao , Qu Yegao , Meng Guang 
Published: May 2021

Abstract
This paper is concerned with the nonlinear behaviors of acoustic waves produced by two degrees-of-freedom rigid oscillators containing nonlinearities and immersed in infinite fluid medium. The vibrations of the oscillators are computed by both the harmonic balance method (HBM) and the direct-time integration scheme, whereas the linearized Euler equations (LEEs) of the acoustic fluid are discretized by a fourth-order dispersion-relation-preserving (DRP) scheme in space and a four-level explicit time marching scheme in time. A constrained moving least-squares (CMLS) immersed boundary method (IBM) is used to enforce the boundary conditions on the common interfaces of the rigid oscillators and the Cartesian grid of the acoustic fluid. A serially staggered procedure is adopted to solve the governing equations of the oscillators and the acoustic fluid as a coupled system. The perfectly matched layer (PML) technique is utilized to damp out the out-going acoustic waves on the boundaries of the truncated computational domain to approximate the nonreflecting wave conditions. Physical insights into the mechanism of the nonlinear acoustic waves induced by super-harmonic resonances, principal resonances, internal resonances, and combination resonances of two degrees-of-freedom nonlinear oscillator systems are provided. The interference fringes of the acoustic waves due to the nonlinear vibration of the system are also discussed. Numerical results show that the sound fields radiated from the vibration system with the above nonlinear behaviors exhibit more complicated interference phenomena since the high-order harmonic components are introduced.
A Scoping Review on College Student Physical Activity: How Do Researchers Measure Activity and Examine Inequities?
Authors: Wilson Oliver W.A. , Panza Michael J. , Evans M. Blair , Bopp Melissa 
Published: May 2021

Background: The purpose of this scoping review was to critically examine the design and quality of contemporary research involving college student physical activity participation, focusing on physical activity measurement, assessment of sociodemographic characteristics, and examination of inequities based on sociodemographic characteristics. Methods: Systematic searches were conducted in 4 electronic databases. Results: From 28,951 sources screened, data were extracted from 488 that met the inclusion criteria. The majority of the studies were cross-sectional in design (91.4%) and employed convenience sampling methods (83.0%). Based on the subsample of studies that reported the percentage of students meeting aerobic (n = 158; equivalent of 150 min/wk of moderate physical activity) and muscle-strengthening activity recommendations (n = 8; ≥2 times/wk), 58.7% and 47.8% of students met aerobic and muscle-strengthening recommendations, respectively. With the exception of age and sex, sociodemographic characteristics were rarely assessed, and inequities based upon them were even more scarcely examined—with no apparent increase in reporting over the past decade. Conclusions: College student physical activity levels remain concerningly low. The generalizability of findings from the contemporary literature is limited due to study design, and acknowledgement of the influence that sociodemographic characteristics have on physical activity has largely been overlooked. Recommendations for future research directions and practices are provided.
Thermochronological constraints on the exhumation history of the Carboniferous Katebasu gold deposit, western Tianshan gold belt, NW China
Authors: Zhao Weice , Zhao Xiaobo , Xue Chunji , Seltmann Reimar , Dolgopolova Alla , Andersen Jens C. , Cui Xinjie , Xing Ling 
Published: May 2021

Abstract

The western Tianshan Gold Belt hosts numerous giant and large gold deposits that have been formed during the late Paleozoic amalgamation of the Tianshan orogen. However, little is known about their exhumation histories during the Mesozoic to Cenozoic intracontinental evolution of the orogen. The Carboniferous Katebasu orogenic gold deposit in northwestern China is a new gold discovery within the western Tianshan Gold Belt, and it shares many similarities with other orogenic gold deposits in the belt. In this contribution, new
40
Ar/
39
Ar and (U–Th)/He ages were combined with previous geochronology and numerical modelling to quantify its post-Carboniferous cooling and exhumation history. The results revealed a three-phase cooling history and two phases of post-mineralization exhumation. We suggest that a large volume (
c.
0.8 km) of the mineralized roof parts of the Katebasu deposit might have been removed during uplift and erosion, whereas significant ore reserves could still exist at depth. The large erosion depth of the Katebasu gold deposit in the Nalati Range of the Chinese western Tianshan also signifies that shallow-emplaced porphyry and epithermal systems that formed prior to Permo-Triassic uplift might have been largely eroded.
EGR1 Addiction in Diffuse Large B-cell Lymphoma
Authors: Kimpara Shuichi , Lu Li , Hoang Nguyet M. , Zhu Fen , Bates Paul D. , Daenthanasanmak Anusara , Zhang Shanxiang , Yang David T. , Kelm Amanda , Liu Yunxia , Li Yangguang , Rosiejka Alexander , Kondapelli Apoorv , Bebel Samantha , Chen Madelyn , Waldmann Thomas A. , Capitini Christian M. , Rui Lixin 
Published: May 2021

AbstractEarly growth response gene (EGR1) is a transcription factor known to be a downstream effector of B-cell receptor signaling and Janus kinase 1 (JAK1) signaling in diffuse large B-cell lymphoma (DLBCL). While EGR1 is characterized as a tumor suppressor in leukemia and multiple myeloma, the role of EGR1 in lymphoma is unknown. Here we demonstrate that EGR1 is a potential oncogene that promotes cell proliferation in DLBCL. IHC analysis revealed that EGR1 expression is elevated in DLBCL compared with normal lymphoid tissues and the level of EGR1 expression is higher in activated B cell–like subtype (ABC) than germinal center B cell–like subtype (GCB). EGR1 expression is required for the survival and proliferation of DLBCL cells. Genomic analyses demonstrated that EGR1 upregulates expression of MYC and E2F pathway genes through the CBP/p300/H3K27ac/BRD4 axis while repressing expression of the type I IFN pathway genes by interaction with the corepressor NAB2. Genetic and pharmacologic inhibition of EGR1 synergizes with the BRD4 inhibitor JQ1 or the type I IFN inducer lenalidomide in growth inhibition of ABC DLBCL both in cell cultures and xenograft mouse models. Therefore, targeting oncogenic EGR1 signaling represents a potential new targeted therapeutic strategy in DLBCL, especially for the more aggressive ABC DLBCL.Implications:The study characterizes EGR1 as a potential oncogene that promotes cell proliferation and defines EGR1 as a new molecular target in DLBCL, the most common non-Hodgkin lymphoma.
Rethinking the Climate–Conflict Nexus: A Human–Environmental–Climate Security Approach
Authors: Daoudy Marwa 
Published: May 2021

Abstract
Scholars of environmental politics and policy experts have long debated whether climate change can be linked to violent conflict. I present a new framework called human–environmental–climate security (HECS), which integrates critiques of traditional security frameworks while offering a systematized method of process tracing. Using existing concepts of vulnerability and resilience, I illustrate the empirical utility of centering the human subject and local conceptions of security when analyzing the role of climate in armed conflict. I develop this framework using the cases of Syria, Sudan, and Morocco. I argue that the ecological drivers of conflicts in Sudan and Syria are best understood as a result of policy decisions that reflected the ideology and preferences of ruling elites rather than direct functions of climate change. Conversely, I present the case of Morocco as a counterfactual in which sound government policy attenuated environmental drivers of conflict. In doing so, this approach considers the impacts of international and domestic structures of inequality on people’s climate vulnerability and resilience.
Prevalence of constipation in adults with obesity class II and III and associated factors
Authors: Silveira Erika Aparecida , Santos Annelisa Silva e Alves de Carvalho , Ribeiro Jessivane Nascimento , Noll Matias , dos Santos Rodrigues Ana Paula , de Oliveira Cesar 
Published: May 2021

Abstract
Background
Constipation and obesity have common risk factors. However, little is known about the occurrence of constipation in individuals with severe obesity and the associated factors.

Objective
To evaluate the prevalence of intestinal constipation and its associated factors in adults with obesity class II and III.

Method
This study analyzed baseline data from a randomized clinical trial with adults aged 18–64 with a Body Mass Index (BMI) ≥ 35 kg/m2, living in the metropolitan region of Goiânia, Brazil. Data were collected using a questionnaire containing sociodemographic, lifestyle, level of obesity, presence of comorbidities, water intake and food consumption variables. The outcome variable was constipation assessed by the Rome III criteria and the Bristol Stool Form Scale. Multiple Poisson regression analysis was used to assess the association between explanatory variables and the outcome.

Results
Among the 150 participants, the prevalence of constipation was 24.67% (95% CI: 17.69–31.64). After multiple regression analyses constipation was associated with polypharmacy (adjusted PR: 2.99, 95% CI: 1.18–7.57, p = 0.021), younger age group i.e. 18–29 years (adjusted PR: 3.12, 95% CI: 1.21–8.06, p = 0.019) and former smoking (adjusted PR: 3.24, 95% CI: 1.28–9.14, p = 0.014). There was no statistically significant association between constipation and daily consumption of fiber-rich foods, however, the non-consumption of whole grains was borderline significant (adjusted PR: 2.92, 95% CI: 1.00 to 8.49, p = 0.050).

Conclusion
A high prevalence of constipation was found in adults with obesity class II and III. Constipation was significantly associated with the simultaneous use of five or more medications, younger age group and being a former smoker.
An Italian individual-level data study investigating on the association between air pollution exposure and Covid-19 severity in primary-care setting
Authors: Pegoraro Valeria , Heiman Franca , Levante Antonella , Urbinati Duccio , Peduto Ilaria 
Published: May 2021

Abstract
Background
Several studies have been focusing on the potential role of atmospheric pollutants in the diffusion and impact on health of Covid-19. This study’s objective was to estimate the association between ≤10 μm diameter particulate matter (PM10) exposure and the likelihood of experiencing pneumonia due to Covid-19 using individual-level data in Italy.

Methods
Information on Covid-19 patients was retrieved from the Italian IQVIA® Longitudinal Patient Database (LPD), a computerized network of general practitioners (GPs) including anonymous data on patients’ consultations and treatments. All patients with a Covid-19 diagnosis during March 18th, 2020 – June 30th, 2020 were included in the study. The date of first Covid-19 registration was the starting point of the 3-month follow-up (Index Date). Patients were classified based on Covid-19-related pneumonia registrations on the Index date and/or during follow-up presence/absence. Each patient was assigned individual exposure by calculating average PM10 during the 30-day period preceding the Index Date, and according to GP’s office province. A multiple generalized linear mixed model, mixed-effects logistic regression, was used to assess the association between PM10 exposure tertiles and the likelihood of experiencing pneumonia.

Results
Among 6483 Covid-19 patients included, 1079 (16.6%) had a diagnosis of pneumonia. Pneumonia patients were older, more frequently men, more health-impaired, and had a higher individual-level exposure to PM10 during the month preceding Covid-19 diagnosis. The mixed-effects model showed that patients whose PM10 exposure level fell in the second tertile had a 30% higher likelihood of having pneumonia than that of first tertile patients, and the risk for those who were in the third tertile was almost doubled.

Conclusion
The consistent findings toward a positive association between PM10 levels and the likelihood of experiencing pneumonia due to Covid-19 make the implementation of new strategies to reduce air pollution more and more urgent.
Investigating the burden of mental distress among nurses at a provincial COVID-19 referral hospital in Indonesia: a cross-sectional study
Authors: Marthoenis  , Maskur  , Fathiariani Liza , Nassimbwa Jacqueline 
Published: May 2021

Abstract
Background
The current outbreak of the COVID-19 pandemic has distorted the physical, mental, and psychological condition of frontline healthcare providers in health facilities. This study aims to investigate the prevalence, and risk factors of depression, anxiety, and stress among nurses working in a COVID-19 referral hospital in Indonesia.

Methods
A cross-sectional study was conducted among 491 nurses, aged between 31, and 56 years, using a self-administered questionnaire. The Depression Anxiety Stress Scale (DASS21), and demographic questions were used to screen the presence of psychological problems, and their associated factors.

Results
The prevalence of moderate to extremely severe depression, anxiety and stress was 8.5 %, 20.6 and 6.3 %, respectively. Regression analysis showed that anxiety was significantly higher among nurses working in non-COVID wards (p = .01), those who experienced social rejection (p < .05), and those who frequently watched television (p < .05). Those who had temporary contracts were more stressed (p < .05), and those who faced financial hardship during the COVID-19 pandemic significantly experienced depression, anxiety, and stress at 10.5 %, 23.5 %, and 8.1 % respectively(p < .05).

Conclusions
While the prevalence of mental distress in this hospital is low, it exists, and hospital management should consider training for all nurses, public sensitization on COVID-19, and provision of financial subsidies for frontline workers, in order to manage the risk factors.
Governance of community health worker programs in a decentralized health system: a qualitative study in the Philippines
Authors: Dodd Warren , Kipp Amy , Nicholson Bethany , Lau Lincoln Leehang , Little Matthew , Walley John , Wei Xiaolin 
Published: May 2021

Abstract
Background
Community health worker (CHW) programs are an important resource in the implementation of universal health coverage (UHC) in many low- and middle-income countries (LMICs). However, in countries with decentralized health systems like the Philippines, the quality and effectiveness of CHW programs may differ across settings due to variations in resource allocation and local politics. In the context of health system decentralization and the push toward UHC in the Philippines, the objective of this study was to explore how the experiences of CHWs across different settings were shaped by the governance and administration of CHW programs.

Methods
We conducted 85 semi-structured interviews with CHWs (n = 74) and CHW administrators (n = 11) in six cities across two provinces (Negros Occidental and Negros Oriental) in the Philippines. Thematic analysis was used to analyze the qualitative data with specific attention to how the experiences of participants differed within and across geographic settings.

Results
Health system decentralization contributed to a number of variations across settings including differences in the quality of human resources and the amount of financial resources allocated to CHW programs. In addition, the quality and provider of CHW training differed across settings, with implications for the capacity of CHWs to address specific health needs in their community. Local politics influenced the governance of CHW programs, with CHWs often feeling pressure to align themselves politically with local leaders in order to maintain their employment.

Conclusions
The functioning of CHW programs can be challenged by health system decentralization through the uneven operationalization of national health priorities at the local level. Building capacity within local governments to adequately resource CHWs and CHW programs will enhance the potential of these programs to act as a bridge between the local health needs of communities and the public health system.
Technical assessment of the NDI Polaris Vega optical tracking system
Authors: Fattori Giovanni , Lomax Antony John , Weber Damien Charles , Safai Sairos 
Published: May 2021

AbstractThe Polaris product line from Northern Digital Inc. is well known for accurate optical tracking measurements in research and medical environments. The Spectra position sensor, to date often found in image guided radiotherapy suites, has however reached its end-of-life, being replaced by the new Vega model. The performance in static and dynamic measurements of this new device has been assessed in controlled laboratory conditions, against the strict requirements for system integration in radiation therapy. The system accuracy has improved with respect to the Spectra in both static (0.045 mm RMSE) and dynamic (0.09 mm IQR, < 20 cm/s) tracking and brings marginal improvement in the measurement latency (14.2 ± 1.8 ms). The system performance was further confirmed under clinical settings with the report of early results from periodic QA tests within specifications. Based on our tests, the Polaris Vega meets the quality standards of radiotherapy applications and can be safely used for monitoring respiratory breathing motion or verifying patient positioning.
Factors contributing to cognitive improvement effects of acupuncture in patients with mild cognitive impairment: a pilot randomized controlled trial
Authors: Kim Jae-Hong , Cho Myoung-Rae , Shin Jeong-Cheol , Park Gwang-Cheon , Lee Jeong-Soon 
Published: May 2021

Abstract
Background
Mild cognitive impairment (MCI) is generally regarded as the borderline between cognitive changes of aging and very early Alzheimer’s disease (AD). It is important to develop easily available interventions to delay the progression of MCI to AD. We investigated factors contributing to the cognitive improvement effects of acupuncture to obtain data for developing optimized acupuncture treatments for MCI.

Methods
This outcome assessor-blinded, randomized controlled trial included a full analysis for comparing the efficacy of different acupuncture methods. Thirty-two participants with MCI (i.e., fulfilling the Peterson diagnostic criteria for MCI, K-MMSE scores of 20–23, and MoCA-K scale scores of 0–22) were randomly assigned to basic acupuncture (BA; GV20, EX-HN1, GB20, and GV24 for 30 min), acupoint specificity (AS; adding KI3 to BA), needle duration (ND; BA for 20 min), or electroacupuncture (EA; electrical stimulation to BA) groups (n=8/group) via 1:1:1:1 allocation and administered acupuncture once daily, three times a week for 8 weeks. The measured outcomes included scores on the Korean version of the Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-K-cog), Korean version of the Montreal Cognitive Assessment scale (MoCA-K), Center for Epidemiological Studies-Depression Scale, Korean Activities of Daily Living scale, Korean Instrumental Activities of Daily Living scale, and European Quality of Life Five Dimension Five Level Scale. Outcome measurements were recorded at baseline (week 0), intervention endpoint (week 8), and 12 weeks after intervention completion (week 20).

Results
Twenty-five patients with MCI completed the trial (BA group, 8; AS group, 6; ND group, 5; EA group, 6). MoCA-K scores were significantly increased in the BA group compared with the ND (p=0.008, week 8–week 0) and EA groups (p=0.003, week 8–week 0; p=0.043, week 20–week 0). ADAS-K-cog scores were significantly decreased in the BA group compared with the ND group (p=0.019, week 20–week 0).

Conclusions
The BA group showed significant improvement in cognitive function compared to the ND and EA groups. Electrical stimulation and needle duration may contribute to the cognitive improvement effects of acupuncture in patients with MCI.

Trial registration
Clinical Research Information Service; URL:cris.nih.go.kr.; unique identifier: KCT0003430 (registration date: January 16, 2019).
Ozone therapy as an alternative method for the treatment of diabetic foot ulcer: a case report
Authors: Faraji Navid , Goli Rasoul , Choobianzali Babak , Bahrami Soheyla , Sadeghian Ali , Sepehrnia Nazila , Ghalandari Mahmoodreza 
Published: May 2021

Abstract
Background
Diabetic foot ulcer (DFU) is one of the most important complications of diabetes that can lead to amputation. Treatment of DFUs is a major challenge and places a heavy economic and social burden on patients and their families.

Case presentation
The present case report is of a 52-year-old kurdish male patient with a 7-year history of type 2 diabetes. While on a bike ride, he sustained a traumatic injury to his right leg, which caused a deep gash measuring 14 × 5 cm on the tibia. During the hospital stay, no improvement was observed after routine wound care including suturing, antibiotic therapy, and dressing change. The patient was referred to our wound-care team. In the first step, the necrotic tissues of his foot ulcer were irrigated and then debrided using mechanical debridement and saline. Next, the patient underwent a 70 μg/dL dose of ozone therapy over a 30-day period in 10 sessions (one 20-minute session every 3 days). Between each session, the patient's wound was wrapped in silver-containing gauze bandages. After 1 month of wound-care using ozone therapy, the patient's foot ulcer had healed and he was discharged from our wound-care service with a stable and good general condition.

Conclusion
Considering the effectiveness of ozone therapy along with silver-containing dressing in the treatment of DFUs, wound-care teams can utilize it as an adjunct to the standard methods of DFU treatment.