bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat
Authors: Olayinka Ebenezer Tunde , Adewole Kayode Ezekiel 
Published: January 2021

Abstract

Objectives
Dutasteride-Tamsulosin (DUT-TAM), a drug of choice for the treatment of prostate enlargement (Benign Prostatic Hyperplasia, BPH) has been implicated in testicular toxicity. This study investigated the protective effect of morin, a plant-derived flavonoid on DUT-TAM-induced testicular toxicity in Wistar rat.

Methods
Twenty-four male Wistar rats (110–140 g) were randomly divided into four treatment groups (n=6). Group A animals served as the control and were administered olive oil, Group B animals were administered 5.4 mg/kg b.w. of dutasteride + 3.4 mg/kg b.w of tamsulosin., Group C animals were administered 100 mg/kg b.w. of morin, while Group D animals were administered DUT-TAM (5.4 mg/kg b.w. of dutasteride + 3.4 mg/kg b.w. of tamsulosin) and morin (100 mg/kg b.w.). The administration lasted for two weeks.

Results
DUT-TAM-induced abnormal sperm morphology (31.8%), significantly reduced (p<0.05) sperm count, sperm motility, live-dead sperm ratio, testicular superoxide dismutase (SOD), catalase, glutathione-S-transferase (GST) and acid phosphatase (ACP) activities, as well as the levels of ascorbic acid and reduced glutathione (GSH) which were ameliorated by co-treatment with morin. Also, DUT-TAM-induced increase in testicular malondialdehyde level and the activities of alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) were significantly reversed (p<0.05) by co-treatment with morin.

Conclusions
These results indicated the protective ability of morin against Dutasteride-Tamsulosin-induced testicular toxicity and oxidative stress.
A prospective controlled study on Ramadan fasting in the healthy young males in summer in Germany: effect on cytokines
Authors: Ghashang Samaneh Khoshandam , Raha Solaiman , Hamdan Imad , Gutenbrunner Christoph , Nugraha Boya 
Published: January 2021

Abstract

Short communication
During the Ramadan fasting (RF) month, participants restrict some activities during day time, particularly consumption of food and beverages. In Germany, Muslims fast about 18–19 h a day when Ramadan falls in the summer. This longer period of restriction could lead to the changes of the body physiology, anthropometric parameters and biological mediators.

Objectives
This study aimed to determine the effect of Ramadan fasting on cytokines (Interleukin (IL)-1β. IL-6, IL-8, IL-10, IL-12, tumor necrosis factor (TNF)-α) during RF in Germany. Correlations of cytokines with anthropometric parameters were also determined.

Methods
Fifty healthy adult males were recruited and divided into two equal groups: fasting group (FG) and non-fasting group (NFG). FG was evaluated at T1: one week before, T2: mid-, T3: last days of, and T4: one week after Ramadan. The NFG were evaluated only at T1 and T3.

Results
In FG significant alterations of IL-1β was observed. Insignificant differences were found between the FG and NFG at T1 and T3 concerning the measured cytokines. Circulating IL-1β increased significantly from T2 to T4 and from T3 to T4. At T3, TNF-α was correlated significantly with anthropometric parameters such as the body weight, the skeletal muscle mass and the fat free mass, whilst IL-12 was correlated significantly with the skeletal muscle mass, the fat free mass and the body water mass at T4.

Conclusions
Significant Alterations of IL-1β during RF in FG were observed. Anthropometric parameters correlate with TNF-α and IL-12 levels during at T3 and T4, respectively.
The effects of an olive-oil massage on hemodialysis patients suffering from fatigue at a hemodialysis unit in southern India – a randomized controlled trial
Authors: Lazarus Eilean Rathinasamy , Deva Amirtharaj Anandhi , Jacob Devakirubai , Chandrababu Ramesh , Isac Chandrani 
Published: January 2021

Abstract

Objectives
To determine the effects that an olive oil massage has on fatigue among patients undergoing hemodialysis, and the associated sociodemographic factors that can reduce fatigue.

Methods
The study used true experimental pre- and post-test research design. A total of 200 patients were recruited in a selected hemodialysis unit in southern India and were allocated to either a study or control group by randomization, with 100 patients in each group. All the patients in the intervention group were given a lower back and lower leg massage using olive oil at the beginning, and after every hour, of their hemodialysis using olive oil for a period of eight weeks. In contrast, the control group continues to receive routine care. The level of fatigue was measured using the Fatigue Severity Scale both before and after massage therapy.

Results
Between 73 and 80% of patients were suffering from severe fatigue and the mean fatigue score was 5.53 (SD 1.82) and 5.56 (SD 1.57) for the study and control group, respectively. After eight weeks of massage therapy, the results showed that 53% of patients in the study group showed borderline fatigue, with a mean score of 4.39 (SD 2.37), whereas in the control group 73% patients showed severe fatigue, with a mean score of 5.17 (SD 2.00). The independent t-test between the study and the control group showed a statistically significant reduction in fatigue in the study group with a mean difference (MD) of 3.56 (t=−1.24; p=0.000). There were also statistically significant changes noted in gender and in the duration of the hemodialysis (χ
2 = 6.043; p=0.049) and (χ
2 = 6.611; p=0.046) respectively.

Conclusion
The study concluded that patients undergoing hemodialysis experienced moderate to severe levels of fatigue. In patients with no or mild anemia, massage has been shown to decrease fatigue and increase energy levels among patients undergoing hemodialysis for chronic kidney disease.
Influence of irisin on diet-induced metabolic syndrome in experimental rat model
Authors: Medhat Dalia , El-Bana Mona A. , El-Daly Sherien M. , Ashour Magdi N. , Elias Tahany R. , Mohamed Rehab A. , Yassen Noha N. , Abdel-Monem Mahmoud A. , Hussein Jihan 
Published: January 2021

Abstract

Objective
To evaluate the influence of irisin on the experimental paradigm of non-alcoholic fatty liver (NAFL) as a part of MetS cluster.

Methods
Forty male albino rats were divided into four groups; normal control, standard diet + irisin, high carbohydrate and fat diet (HCHF), and HCHF + irisin. After the experimental period, levels of fasting blood sugar (FBS), insulin, lipid profile, kidney functions, salusin-alpha (Sal-α), adropin, and retinol-binding protein-4 (RBP-4) were evaluated. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α) expression in skeletal muscle was evaluated by quantitative real-time PCR. Aorta, liver, pancreas, and skeletal muscle tissue samples were prepared for histopathological examination.

Results
Rats administrated HCHF showed elevated levels of FBS, lipid profile, kidney functions, RBP-4, and downregulation of PGC-1α expression along with a decline in levels of insulin, Sal-α, and adropin while administration of irisin significantly attenuated these levels.

Conclusions
Irisin as based therapy could emerge as a new line of treatment against MetS and its related diseases.
Functional status in adhesive capsulitis – yoga vs. physiotherapy: a quasi experimental study
Authors: Pitchai Pothiraj , Krishnan Vijaya , Mangle Komal 
Published: January 2021

Abstract

Objectives
Adhesive capsulitis results in a multidimensional disability which demands a polygonal approach. Although physiotherapy proves an essential for a complete and comprehensive recovery in adhesive capsulitis, evidence also suggest the role of yoga in the management, hence this study investigate their effectiveness.

Methods
This is a quasi-randomised control study. A pre-diagnosed subacute and chronic adhesive capsulitis of shoulder, between the age group of 35–60 years of both genders of total 40 participants were randomly divided into Group ‘A’ (yogasana) and Group ‘B’ (physiotherapy). The parameters of pain, joint mobility and functional disabilities were measured at the baseline and after four-weeks.

Results
The mean age of Group ‘A’ was 45.4 ± 7.78 years whereas 50.05 ± 5.98 years was in Group ‘B’. Intragroup analysis for both the groups showed statistically significant improvement in all the study variables. Whereas in intergroup analysis yogasana was found to be statistically significant in improving shoulder abduction mobility, p=0.03, effect size r=0.35 and also in shoulder flexion (p=0.15, r=0.23) and shoulder internal rotation (p=0.07, r=0.3), though statistically not significant, in view of small effect size response.

Conclusions
Both techniques improved the functional status in adhesive capsulitis, however additional effects on joint mobility was demonstrated by yogasana.
Nonlinear dynamics of pulsating detonation wave with two-stage chemical kinetics in the shock-attached frame
Authors: Poroshyna Yaroslava E. , Lopato Aleksander I. , Utkin Pavel S. 
Published: January 2021

Abstract
The paper contributes to the clarification of the mechanism of one-dimensional pulsating detonation wave propagation for the transition regime with two-scale pulsations.
For this purpose, a novel numerical algorithm has been developed for the numerical investigation of the gaseous pulsating detonation wave using the two-stage model of kinetics of chemical reactions in the shock-attached frame.
The influence of grid resolution, approximation order and the type of rear boundary conditions on the solution has been studied for four main regimes of detonation wave propagation for this model.
Comparison of dynamics of pulsations with results of other authors has been carried out.
A Skellam regression model for quantifying positional value in soccer
Authors: Pelechrinis Konstantinos , Winston Wayne 
Published: January 2021

Abstract
Soccer is undeniably the most popular sport world-wide and everyone from general managers and coaching staff to fans and media are interested in evaluating players’ performance. Metrics applied successfully in other sports, such as the (adjusted) +/− that allows for division of credit among a basketball team’s players, exhibit several challenges when applied to soccer due to severe co-linearities. Recently, a number of player evaluation metrics have been developed utilizing optical tracking data, but they are based on proprietary data. In this work, our objective is to develop an open framework that can estimate the expected contribution of a soccer player to his team’s winning chances using publicly available data. In particular, using data from (i) approximately 20,000 games from 11 European leagues over eight seasons, and, (ii) player ratings from the FIFA video game, we estimate through a Skellam regression model the importance of every line (attackers, midfielders, defenders and goalkeeping) in winning a soccer game. We consequently translate the model to expected league points added above a replacement player (eLPAR). This model can further be used as a guide for allocating a team’s salary budget to players based on their expected contributions on the pitch. We showcase similar applications using annual salary data from the English Premier League and identify evidence that in our dataset the market appears to under-value defensive line players relative to goalkeepers.
Represent 255: language, style and the construction of identity in Tanzanian English hip-hop
Authors: Adjirakor Nikitta Dede 
Published: January 2021

AbstractFrom its encouraged and sustained use during colonial times, through to the creation of the Tanzanian state, the Swahili language has been consistently constructed as one of the key facets of Tanzanian identity. After the emergence of hip-hop in Tanzania, the shift from English to Swahili was instrumental to its widespread adoption, with English gaining a symbolic meaning as a status marker as well as a language for international positioning. This article argues that recently, a rising number of hip-hop artists style themselves as purely English-speaking artists to construct a Tanzanian identity that challenges the dominant positioning of Swahili. To this end, I explore through selected texts how English is used to construct a cosmopolitan niche and urban identity that serves as a counternarrative to the dominance of Swahili in the popular imagination. Through hip-hop songs, groups and performance events, I show how English is used to evoke experiences of belonging that are positioned as authentic narratives that juxtapose rather than contradict a Tanzanian identity.
Mixed convection flow in a vertical channel in the presence of wall conduction, variable thermal conductivity and viscosity
Authors: Ajibade Abiodun O. , Umar Ayuba M. 
Published: January 2021

AbstractThis study theoretically investigates the effects of variable viscosity, thermal conductivity and wall conduction on a steady mixed convection flow of heat generating/absorbing fluid passes through a vertical channel. One of the channel plates moves with a constant velocity while the other is stationary. The governing flow equations are solved analytically using homotopy perturbation method (HPM). The effects of the thermophysical and hydrodynamics parameters are captured in graphs and tables. It has been observed that, both the velocity and temperature distributions decrease with increase in viscosity and boundary plate thickness near the heated plate while a reverse cases were observed near the cold plate. Increase in thermal conductivity ε decreases the fluid flow near the heated plate. When the boundary plate thickness is increased, the critical value of Gre to onset the reverse flow increases while increase in thermal conductivity reduces the critical value of Gre. It’s also noticed that the skin friction and rate of heat transfer at the heated plate decrease with increase in boundary plate thickness d.
On solitary wave solutions of a peptide group system with higher order saturable nonlinearity
Authors: Inc Mustafa , Elhassanein Ahmed , Abdou Mohamed Aly Mohamed , Chu Yu-Ming 
Published: January 2021

Abstract
In this article, a new continuous model of a peptide group system with higher order saturable nonlinearity is derived. The model is constructed up on discrete Schrodinger equation with higher order saturable nonlinearity. New exact solutions of the proposed model are investigated. Via the generalized Riccati equation mapping method travelling wave and soliton solutions are derived. For certain values of parameters kink, antikink, breathers, and dark and bright solitons are presented.
Association of expression and genotypes of thymidylate synthase in non-small cell lung cancer patients with different clinicopathological characteristics
Authors: Chen Jin-Yin , Chen He-Jian , Chen Pei-Feng 
Published: January 2021

Abstract

Objective
To explore the expression and genotypes of thymidylate synthase (TS) in patients of non-small cell lung cancer (NSCLC) with different clinicopathological characteristics.

Methods
The expression profiles of TS were examined by immunohistochemical staining and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) in 160 patients with NSCLC. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect TS-5′UTR tandem repeats, G/C nucleotide polymorphisms, and 3′UTR 6 bp deletion/insertion polymorphisms. The relationships between clinicopathological characteristics and TS expression or genotypes were investigated through χ
2 test. Kaplan–Meier survival analysis was used to analyze the association between TS expression and overall survival (OS) and disease-free survival (DFS) of NSCLC patients.

Results
The expression levels of TS protein and TS gene in NSCLC tissues were significantly higher than that in paracancerous tissues (P < 0.05). Furthermore, high expression of TS protein and 5′UTR polymorphism of TS gene showed significant correlation with differentiation, TNM stage, and lymph node metastases. The frequency of −6 bp/−6 bp genotypes in patients with NSCLC was 43.13% (69/160), which was higher than others. In addition, the rate of TS protein overexpression in NSCLC patients with 3R/3R was 79.79%, which was higher than others. Interestingly, high expression of TS protein predicted shorter DFS and OS and lower 3-year DFS rate and 3-year OS rate.

Conclusions
The expression levels of TS in NSCLC were significantly increased and may help to predict the prognosis of NSCLC, and high expression of TS protein and 5′UTR polymorphism of TS gene were significantly related to differentiation, TNM stage, and lymph node metastases.
The possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review
Authors: Moslehi Roxana , Stagnar Cristy , Srinivasan Sneha , Radziszowski Pawel , Carpenter David O. 
Published: January 2021

Abstract
The roles of many environmental contaminants in increasing breast cancer risk remain controversial. Arsenic (As) is a major global environmental contaminant and carcinogen. We conducted a systematic review of the role of As and gene-arsenic interactions in susceptibility to breast cancer. Following a systematic literature search using well-defined inclusion/exclusion criteria, a total of 15 epidemiologic studies (two meta-analyses, three systematic reviews, three cohort studies, two case-control studies, and five cross-sectional studies) were reviewed. In addition, several animal, in vitro, in vivo, and in silico (i.e., computer modeling) studies provided mechanistic insights into the association between As and breast cancer. Our review suggests a possible overall main effect of As on breast cancer risk. The evidence for an effect of gene-As interactions on breast cancer risk is strong. Studies that measured levels of As metabolites among participants and/or evaluated interactions between As exposure and genetic or epigenetic factors generally reported positive associations with breast cancer risk. Our analysis of the Comparative Toxicogenomics and the Ingenuity Pathway Analysis Databases provided further evidence for As-gene interactions and their effects on breast cancer-related biologic pathways. Our findings provide potential leads for future epidemiologic studies of As-associated cancer risks and interventions to reduce population exposure.
Deutsche Arbeitswelten zwischen globalen Problemlagen und nationalen Handlungsbezügen
Authors: Raphael Lutz 
Published: January 2021

Abstract
Zeithistorische Studien zu Arbeitswelten in Deutschland erleben einen Neustart nach dem Auslaufen der klassischen gesellschaftshistorischen und arbeiterbewegungsgeschichtlichen Forschungen zum Industriezeitalter in Deutschland (1880–1970). Die neuen Forschungen sind geprägt von der Umbruchsituation der Gegenwart, sie sind geprägt von widerstreitenden Erkenntnisinteressen zwischen Global- und Nationalgeschichte, zwischen einer radikalen Ausweitung des Forschungsgegenstands auf jede Art von Tätigkeit und der Konzentration auf lohnabhängige Beschäftigungsformen. Der Aufsatz plädiert für das Innovationspotenzial einer neuen Arbeitsgeschichte als einer Problemgeschichte der Gegenwart auf den Gebieten der Geschlechtergeschichte, der Geschichte von Klassenlagen und Ungleichheit, nationaler Ordnungsmuster von Arbeit, der Mikropolitik in Betrieben sowie der Wissensordnungen und Berufswelten.
Emanzipatorischer Aufbruch und antisemitische Verfolgung
Authors: Nattermann Ruth 
Published: January 2021

Abstract
Auf der Grundlage neu erschlossener Quellen untersucht der Aufsatz die Erfahrungen italienisch-jüdischer Feministinnen zwischen emanzipatorischem Aufbruch und antisemitischer Verfolgung. Den zeitlichen Schwerpunkt bildet die Phase vom Beginn des Ersten Weltkriegs bis 1945. Verdeutlicht werden die um 1914 zunehmenden Spannungen des Emanzipationsprozesses zwischen Partizipation, Abgrenzung und antijüdischer Anfeindung. Die Marginalisierung, Entrechtung und Verfolgung während der faschistischen Diktatur werden dezidiert aus dem Blickwinkel jüdischer Frauen betrachtet. Trotz des bedeutenden Einflusses dieser jüdischen Frauen auf die Entwicklung der italienischen Frauenbewegung und ihre ausgeprägt transnationale Orientierung blieb ihre Emanzipation als Frauen und Jüdinnen unvollkommen.
Der Aufbau des Sozialismus
Authors: Radu Sorin 
Published: January 2021

Abstract
Die politische Schulung der kommunistischen Parteieliten und der Parteibürokraten durch Kaderschulen ist ein Forschungsthema, das unser Verständnis der Funktionsweise des Ostblockkommunismus und der dortigen dynamischen Beziehung zwischen Staat und Gesellschaft vertiefen kann. Ein derartiger Zugang erlaubt es Forscherinnen und Forschern, das Universum des Parteiapparats zu verstehen, ein komplexeres Profil dieser Welt zu zeichnen und die internen Mechanismen der Einparteienherrschaft zu verstehen. Aus diesen Gründen ist die Erforschung der politischen und ideologischen Ausbildung ein notwendiger Schritt hin zu einer detaillierten Geschichte des osteuropäischen Kommunismus. Die vorliegende Studie konzentriert sich auf eine Untersuchung der regionalen Parteischule von Timișoara in den Jahren von 1948 bis 1973, die Parteiaktivisten „aus der zweiten Reihe“ der Partei- und Verwaltungsbürokratie politisch und ideologisch schulte.
"Manicomio español"
Authors: Castro de Paz José Luis 
Published: January 2021

En 1953, en plena madurez intelectual y cuando ya es uno de los más famosos actores de España, Fernando Fernán-Gómez —de quien se celebra en 2021 el centenario de su nacimiento— debuta como director cinematográfico con Manicomio, un filme tan modesto como excéntrico que reune cuatro historias de Edgar Allan Poe, Aleksadr Ivanovich Kuprin, Leonidas Andreiev y Ramón Gómez de la Serna en su primera adaptación cinematográfica (“La mona de imitación”). En la película, Fernán-Gómez traza un tan oscuro como deslavazado dibujo metafórico de una España desquiciada en la que gobiernan los locos, mientras los intelectuales —como un inolvidable Camilo José Cela— cocean cual burros encerrados en un delirante manicomio. Pueden intuirse ya en el texto, más o menos embrionariamente, rasgos sainetescos y deformantes —el protagonista (el propio Fernán-Gómez) hablándole a los espectadores; el maltrechotono costumbrista del episodio ramoniano protagonizado por Antonio Vico y Elvira Quintillá— que constituirán las bases del futuro estilo del autor de El mundo sigue (1963) o El extraño viaje (1964).