bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmented Rehabilitation Program for Young Patients Following Total Hip Arthroplasty- Feasibility Study
Authors: Negm Ahmed M. , Yavarai Milad , Jhangri Gian S. , Haennel Robert , Jones C. Allyson 
Published: May 2021

Abstract
Background: The increase rate seen in total hip arthroplasty (THA) for younger patients (< 60) has implications for future rehabilitation demands for primary and revision THA surgery. The primary objective is to examine the feasibility of a study comparing a 6-week post-operative rehabilitation program to usual care in patients ≤ 60 years undergoing elective unilateral THA. The secondary objectives are: 1) to explore the effect of a 6-week post-operative rehabilitation program designed for THA patients ≤ 60 years on physical activity (PA), function and participants’ satisfaction compared to age- and sex-matched control group received usual postoperative care at 12-week post-THA. 2) to examine the correlation between physical activity and self-reported pain and function.Methods: In this study, a cohort of THA candidates were recruited during their 6-week postoperative visit to their surgeons at a central intake clinic. The out-patient rehabilitation program, which was designed to improve function and increase activity, consisted of 12 structured exercise classes (2 hrs/class) on land and water over 6 weeks. Physical activity was assessed using Sense Wear Pro ArmbandTM [SWA]. Participants completed the Hip Osteoarthritis Outcome Score (HOOS), and THA satisfaction questionnaire before and immediately after the intervention.Results: Of the 24 participants recruited, 14 participants received the augmented rehabilitation, and 10 participants were in the control group. All the study participants in the control and intervention groups completed the baseline and follow-up assessments without adverse events. Thirteen out of the fourteen intervention group participants completed at least 80% of the intervention sessions. The intervention group took significantly more steps/day (mean difference = 2,440 steps/day, 95% CI= 1678, 4712) (p<0.05), at the follow-up compared to baseline. The intervention group had a higher mean change of number of weekly PA bouts than the control group. Within the intervention group, all HOOS subscales were significantly higher at the follow-up compared to baseline. However, the ADL subscale was the only significant difference seen with the control group.Conclusion: The study intervention and assessments were feasible and safe in patients ≤ 60 years undergoing elective unilateral THA.
Perceived Stress and Post-Traumatic Stress Disorder Symptoms Among Intensive Care Unit Staff Caring for Severely Ill Coronavirus Disease 2019 Patients During the Pandemic: A National Study
Authors: Kader Nisha , Elhusein Bushra , Chandrappa Nirvana , Nashwan Abdulqadir J , Chandra Prem , Khan Abdul Waheed , Alabdulla Majid 
Published: May 2021

Abstract
Background: Intensive care unit (ICU) staff have faced unprecedented challenges during the coronavirus disease 2019 (COVID-19) pandemic, which could significantly affect their mental health and well-being. The present study aimed to investigate perceived stress and post-traumatic stress disorder (PTSD) symptoms reported by ICU staff working directly with COVID-19 patients. Methods: The Perceived Stress Scale was used to assess perceived stress, the PTSD Diagnostic Scale for the Diagnostic and Statistical Manual of Mental Disorders (5th edition) was used to determine PTSD symptoms, and a sociodemographic questionnaire was used to record different sociodemographic variables. Results: Altogether, 124 participants (57.2% of whom were men) were included in the analysis. The majority of participants perceived working in the ICU with COVID-19 patients as moderately to severely stressful. Moreover, 71.4% of doctors and 74.4% of nurses experienced moderate to severe perceived stress. The staff with previous ICU experience were less likely to have a probable diagnosis of PTSD than those without previous ICU experience. Conclusions: Assessing perceived stress levels and PTSD among ICU staff may enhance our understanding of COVID-19-induced mental health challenges. Specific strategies to enhance ICU staff’s mental well-being during the COVID-19 pandemic should be employed and monitored regularly. Interventions aimed at alleviating sources of anxiety in a high-stress environment may reduce the likelihood of developing PTSD.
Development of a Compensation-aware Virtual Rehabilitation System for Upper Extremity Rehabilitation in Community-Dwelling Older Adults with Stroke
Authors: Luo Zhiqiang , Lim Audrey Ei-Ping , Durairaj Ponraj , Tan Kim Kiow , Verawaty Verawaty 
Published: May 2021

Abstract
Background: Compensatory movements are commonly observed in older adults with stroke when they take motor practice for rehabilitation, which could limit their motor recovery.Aim: This study aims to develop one virtual rehabilitation system (VRS) that can detect and reduce compensatory movements to improve the quality of upper extremity (UE) movements and hence the outcome of rehabilitation in community-dwelling older adults with stroke. Method: To design and validate the algorithm of compensation detection equipped in VRS, a study was first conducted to recruit 17 healthy and 6 stroke participants to identify and quantify compensatory movements when they played rehabilitation games provided by the VRS. Then a pilot study was conducted to test the feasibility and efficacy of the VRS deployed in community, where 18 stroke participants were assigned to either virtual reality (VR) group or conventional treatment (CT) group, and each participant underwent 10 sessions of an additional 6 minutes of VR games or CT respectively, on top of their usual rehabilitation programme. Participants were assessed before and after interventions using Fugl-Meyer Assessment-Upper Extremity (FMA-UE), Wolf Motor Function Test(WMFT), Stroke Rehabilitation Motivation Scale (SRMS), Range of Motion (ROM) measurements and the number of compensatory movements.Results: VR group demonstrated a trend in reduction of trunk and upper-extremity compensations, increased intrinsic motivation scores, and statistically significant improvements in FMA-UE (p=0.045) and WMFT (p=0.009, p=0.0355) scores. There was, however, no significant difference in all outcome measures between two groups. Conclusion: The compensation-aware VRS demonstrates a trend towards reduced compensation and higher motivation level, which could be an effective adjunct to the conventional therapy with less supervision from a therapist as well as be potentially deployed in a community center or at an elder adult’s home.
BCl3 Adsorption on Pristine, S-Doped, and Cr-Doped Graphynes: A DFT Study
Authors: Derakhshandeh Maryam 
Published: May 2021

Abstract
The adsorption of boron trichloride (BCl3) was explored onto pristine, S-doped, and Cr-doped graphyne through density functional theory computations. The interaction of BCl3 with pristine graphyne was weak and, thus, this sheet cannot be used as a sensor. Although S-doping strengthens the interaction, the S-doped sheet cannot still be used as a sensor. However, the reactivity and sensitivity of the sheet are significantly increased toward BCl3 by replacing the C atom of graphyne with the transition metal Cr. The HOMO-LUMO gap of Cr-doped graphyne reduces from 2.18 to 1.38 eV following the adsorption of BCl3, which significantly increases the electrical conductivity. Thus, the great change in the conductivity can be converted into an electronic signal, indicating that Cr-doped graphyne may be a promising sensor for BCl3. Also, its work function is considerably decreased by the adsorption process, indicating that it can also work as a work function-type sensor for BCl3 detection.
Changing the Sensitivity and Operating Range of the Ba2MgWO6 : Eu3+ Optical Thermometer by Applying the Distinct Synthesis Routes
Authors: Vu T. H. Quan , Bondzior Bartosz , Stefańska Dagmara , Miniajluk-Gaweł Natalia , Winiarski Maciej J. , Dereń Przemysław J. 
Published: May 2021

Abstract
The suitability of Ba2MgWO6 (BMW) double perovskite doped with Eu3+ for the construction of an optical thermometer was tested. It has been shown that by controlling the conditions of BMW synthesis, the sensitivity of the optical thermometer and the useful range of its work can be changed. Pure BMW and doped with Eu3+ samples were prepared using the mechano-chemical (MC) and co-precipitation (CP) methods. Both the absolute sensitivity and the relative sensitivity in relation to the synthesis route are estimated. The findings proved that the relative sensitivity can be modulated from 1.17 %K− 1 at 248 K, to 1.5%K− 1 at 120 K for the co-precipitation and the mechanochemical samples, respectively. These spectacular results confirm the applicability of the Ba2MgWO6: Eu3+ for the novel luminescent sensors in high-precision temperature detection devices. Density-functional theory (DFT) was applied to elucidate the origin of the host emission.
Title: Significance of D-dimer in acute ischemic stroke patients with large vessel occlusion accompanied by active cancer
Authors: Pan Kwang Hyun , Kim Jaeyoun , Chung Jong-Won , Kim Keon Ha , Bang Oh Young , Jeon Pyoung , Kim Gyeong-Moon , Seo Woo-Keun 
Published: May 2021

Abstract
Background: This study aimed to investigate clinical outcome predictors of acute stroke patients with large vessel occlusion and active cancer and validate the significance of d-dimer levels for endovascular thrombectomy decisions.Methods: We analyzed a prospectively collected hospital-based stroke registry to determine clinical EVT outcomes of acute stroke patients within 24 hours with following criteria: age≥18 years, NIHSS≥6, and internal carotid artery or middle cerebral artery lesion. All patients were classified into EVT and non-EVT groups. Patients were divided into two groups by initial d-dimer level. We explored variables potentially associated with successful recanalization as well as 3-month functional outcomes and mortality rates. Results: Among 68 patients, 36 were treated with EVT, with successful recanalization in 55.6%. The low d-dimer group showed a higher rate of successful recanalization and favorable outcome than the high d-dimer group. The mortality rate was higher in the high d-dimer group. EVT and high d-dimer level were independent predictors of mortality, whereas lesion volume and low d-dimer level were independently associated with favorable outcomes.Conclusions: d-dimer level is a prognostic factor in acute LVO stroke patients with active cancer, and its high value for EVT decisions provisionally supports its testing in this patient population.
Vegetation Phenology and Its Response to Climate Change in Extremely Arid Area: A Case Study of Populus Euphratica in The Upper Tarim River Basin, NW China
Authors: Li Hualin , Feng Jianzhong , bai Linyan , Zhang Jianjun 
Published: May 2021

Abstract
Quantifying the phenological variations of Populus euphratica (P. euphratica) resulting from climate change is vital for desert ecosystems in extremely arid regions. P. euphratica phenology and its response to climate change are lacking in extremely arid area. In this study, a modified method was proposed to explore P. euphratica phenology and its response to climate change using 15-year Global LAnd Surface Satellite (GLASS) leaf area index (LAI) time-series data (2002–2016) in the upper Tarim River basin. The start of the growing season (SOS), length of the growing season (LOS), and end of the growing season (EOS) were obtained with the dynamic threshold method from the reconstructed growth time series curve by using the Savitzky-Golay filtering method. The grey relational analysis (GRA) method was utilized to analyze the correlation between the phenological features of P. euphratica and climatic factors. Importantly, we also revealed the positive and negative effects between interannual climate factors and P. euphratica phenology using the canonical correlation analysis (CCA) method, and the interaction between the SOS in spring and EOS in autumn. The results revealed that the SOS of P. euphratica was delayed by about 5.3 days/10a, while EOS was advanced by about 3.1 days/10a. The phenology of P. euphratica was extensively changed, with high spatial heterogeneity. Spring sunshine duration (SD) and average air temperature (AT) controlled the SOS and EOS, although the impacts of average relative humidity (RH) and precipitation (PR) on phenology cannot be overlooked. The SOS was positively correlated with the EOS, implying a later SOS may generally be accompanied by a later EOS. Global warming may lead to SOS advance and EOS delay, and the increase of SD may lead to later SOS and earlier EOS. Groundwater was found to be a key factor for controlling P. euphratica phenology than runoff in this region.
Reduced frequency of migraine attacks following COVID-19 disease
Authors: Houben Roland 
Published: May 2021

Abstract
Introduction:SARS-CoV-2 is a virus affecting different organs and causing a wide variety and severity of symptoms. Case Presentation:Here we report on a 57-year old male patient with chronic migraine and medication overuse headache who fell ill with COVID-19. For many years prior to his Sars-Cov2 infection he suffered from very frequent migraine attacks and for control of headache he had been taking triptans almost daily. In the 16-month period before outbreak of COVID-19 on 98% of the days triptans were taken with only a 21-day prednisolone-supported triptan holiday, which, however, had no longer-lasting consequences on migraine frequency. Upon Sars-Cov2 infection, the patient developed only mild symptoms including fever, fatigue and headache. Directly following recovery from COVID-19 the patient surprisingly experienced a period with largely reduced frequency and severity of migraine attacks. Indeed, during 80 days following COVID-19, migraine as well as triptan usage were restricted to only 25% of the days no more fulfilling criteria of chronic migraine and medication overuse headache.Conclusion:SARS-CoV-2 infection might be capable of triggering mitigation of migraine.
Patient and caregiver perspectives on a tool to identify undiagnosed dementia: A qualitative study
Authors: Palazzo Lorella , Hsu Clarissa , Barnes Deborah , Figueroa-Gray Marlaine , Greenwood-Hickman Mikael Anne , Larson Eric , Dublin Sascha 
Published: May 2021

Abstract
BACKGROUND Early detection of dementia may improve patient care and quality of life, yet as many as half of patients are undiagnosed. Electronic health record (EHR) data could potentially be used to help to identify patients at risk of having undiagnosed dementia who could be targeted for outreach and assessment, but acceptability to patients and caregivers is unknown. METHOD We conducted five focus groups at Kaiser Permanente Washington, an integrated healthcare system in Washington State, to explore feelings about timing of dementia diagnosis, use of EHR-33 based tools to predict risk of undiagnosed dementia, and communication about risk. Two team members analyzed transcripts using inductive thematic coding. RESULTS Participant groups included: patients with dementia or mild cognitive impairment, patients with neither diagnosis, and caregivers. People who were non-white or Hispanic were oversampled. Forty patients and caregivers (63% women; 59% non-white/Hispanic) participated in focus 39 groups. Participants supported early diagnosis, describing benefits such as time to adjust to the disease, plan, involve caregivers, and identify resources. They also acknowledged the possible psychosocial toll of receiving the diagnosis. Participants also supported use of an EHR-based tool, but some worried about accuracy and privacy. Participants emphasized that information about dementia risk should be communicated thoughtfully by a trusted provider and should include advice about prognosis, treatment options and other resources. CONCLUSION Overall, patients and caregivers supported using EHR-based tools to help identify patients at risk of having undiagnosed dementia. Such tools must be implemented carefully to address concerns and ensure patients and caregivers are adequately supported.
Decreased HECTD1 mRNA expression is associated with poor prognosis and enhanced mitochondrial cellular respiratory function in breast cancer
Authors: Uemoto Yasuaki , Katsuta Eriko , Kondo Naoto , Wanifuchi-Endo Yumi , Fujita Takashi , Asano Tomoko , Hisada Tomoka , Terada Mitsuo , Kato Akiko , Okuda Katsuhiro , Sugiura Hiroshi , Kato Hiroyuki , Osaga Satoshi , Takahashi Satoru , Toyama Tatsuya 
Published: May 2021

Abstract
HECT domain E3 ubiquitin ligase 1 (HECTD1) has been reported to be a negative regulator of epithelial-mesenchymal transition and to decrease breast cancer invasion and metastasis. However, the clinical significance and detailed role of HECTD1 in breast cancer remain elusive. We investigated the role of HECTD1 in two large breast cancer cohorts using mRNA and protein expression, and bioinformatics. We examined the prognostic significance of HECTD1 by multivariate analysis. HECTD1 mRNA expression (HECTD1 expression) was lower in breast cancer compared with adjacent normal tissues. HECTD1 expression levels also differed among breast cancer subtypes. Decreased HECTD1 expression was significantly associated with aggressive tumour characteristics, including large tumour size and high histological grade. HECTD1 expression was inversely associated with mitochondrial cellular respiratory function and reactive oxygen species in breast cancer tissues. Multivariate analysis identified low HECTD1 mRNA expression level as an independent risk factor for disease-free (P = 0.009) and overall (P = 0.046) survival among breast cancer patients. There was no association of HECTD1 protein expression with mRNA expression and prognosis. HECTD1 mRNA expression is a candidate prognostic biomarker in breast cancer. The poor prognosis of patients with low HECTD1 mRNA expression may be associated with increased mitochondrial respiratory function.
Microwave sinteringof duplex α/β-SiAlON ceramic cutting inserts: modifying m, n, z values, sintering temperature and excess Y2O3 sintering additive
Authors: Hong Dongbo , Yin Zengbin , Guo Fuzhou , Yuan Juntang 
Published: May 2021

Abstract
Duplex α/β-SiAlON ceramic cutting inserts (30α: 70β) were fabricated by microwave sintering. The effects of solid solution parameters (m, n, z), sintering temperature and amount of excess Y2O3 sintering additive on phase assemblage, microstructure, mechanical properties and cutting performance were investigated. It was found that increasing m value could improve the formation of α phase while high z value over 1.0 would lead to the dissolution of α phase into β phase and intergranular phase. Increasing amount of excess Y2O3 could promote densification and elongated β grain growth, but the excess Y2O3 over 4 wt.% would result in substantial crystallization of M'SS phase thus declining the mechanical properties and wear resistance. The microwave-sintered α/β-SiAlON cutting insert with modified parameters (m = 1.7, n = 1.0, z = 0.7 and 3 wt.% excess Y2O3) was obtained with optimal comprehensive properties, whose tool life was increased by approximately 75% in high-speed milling of Inconel718 superalloy as compared with commercial α/β-SiAlON cutting insert.
Broad lipid phase transitions in mammalian cell membranes measured by Laurdan fluorescence spectroscopy
Authors: Faerber Nicolas , Westerhausen Christoph 
Published: May 2021

Abstract
Employing fluorescence spectroscopy and the membrane-embedded dye Laurdan we experimentally show broad order-disorder-transitions in membranes of various cell lines and red blood cell ghosts. A custom-made setup allows for the determination of fluorescence spectra and the determination of the generalized polarization (GP) as a measure for membrane order in the temperature range of -40°C to +90°C of µl-volumes of cell suspension. While artificial lipid membranes like phosphatidylcholine show sharp transitions as known from calorimetry measurements, living cells in a physiological temperature range do only show linear changes in generalized polarization. However, extending the temperature range shows the existence of broad transitions and their sensitivity to cholesterol content, pH and anaesthetic. Moreover, adaptation to culture conditions like decreased temperature and morphological changes like detachment of adherent cells or dendrite growth are accompanied by changes in membrane order as well. The observed GP changes are equivalent to temperature changes dT in the range of -12K < dT <+6K
System for Prevention and Control of Old Goaf Water during Coal Mine Re-mining
Authors: Dong Shuning , Li Xiaolong , Ma Liuzhu 
Published: May 2021

Abstract
One integrated mine was currently threatened with an old goaf water disaster, therefore, the development of an advanced detection-guarantee system for roadway excavation with no blind area was imperative. Further, multiple geophysical exploration in combination with two types of boreholes were used to explore and drain water technology, with the anomalous geophysical area as the target area, The conventional borehole with the largest water outflow was taken as the target spot, at a low elevation of the mining area, and a remote directional borehole was used to drill into the old goaf along the stable rock strata below the coal seam floor to intercept the dynamic recharge water, which increased the efficiency of roadway excavation 4–9 times. The ‘isolated island’ old goaf water in the mining face was controlled through multiple geophysical exploration combined with the full-coverage exploration technology by conventional boreholes, and the water-rich anomalous area and geological anomalous area were determined, thus ensuring the safety of the mining face in terms of old goaf water. The technology for advanced short-distance exploration, advanced estimate, roadway exploration, and dynamic old goaf water with drainage was used to comprehensively guarantee real-time, safe mining. This system for the prevention and control of old goaf water was applied to a control project for the old goaf water disaster in the 101 mining face. At present, 1.37 Mt of coal has been safely mined from this mining face. The technical system has improved The Detailed Rules for Water Disaster Prevention and Control of Coal Mine (NCMSA 2018), and improved the technology for the prevention and control of old goaf water under conditions where the upper portion in the same coal seam was destroyed by a small-scale coal mine and re-mining.
A Study on the Predictive Maintenance Method of Fully Mechanized Mining Equipment based on Cost and Time Factors
Authors: Cao Xiangang , Xu Tianbo , Zhao Youjun , Zhao Jiangbin , Wang Yan 
Published: May 2021

Abstract
In view of the problems of excessive maintenance and insufficient utilization of equipment service life caused by preventive maintenance of fully mechanized mining equipment with fixed cycle, a predictive maintenance method is proposed. Firstly, based on Weibull distribution function and evolution rules of equipment decay, the evolution model of equipment failure rate is established; Then, the single-objective decision-making models of equipment maintenance cost rate and maintenance downtime rate are established respectively. On this basis, the multi-objective predictive maintenance planning model of fully mechanized mining equipment with comprehensive cost and time factors is established, and the optimal predictive maintenance cycle planning sequence is obtained. Combined with the coal production continuation plan, this paper puts forward a method to determine the optimal maintenance time by making suitable choices between advance maintenance and delay maintenance. The result confirms the effectiveness and superiority of the proposed method.