bluuebunny/crossref_metadata_2025_split huggingface dataset:
Average annual total sunspot area in the last 410 yr: the most probable values and limits of their uncertainties
Authors: Nagovitsyn Yury A , Osipova Aleksandra A 
Published: May 2021

ABSTRACTThe aim of this work is to create a long (410-yr) series of average annual total sunspot areas AR – a physically based index of sunspot activity. We use telescopic observations of the AR index in 1832–1868 and 1875–2020, as well as the relationship between AR and long series of sunspot indices SN (international sunspot numbers, version 2.0) and sunspot groups GN (Svalgaard and Schatten’s version of group sunspot numbers). The Royal Greenwich Observatory series after 1976 is extended by the Kislovodsk Mountain Astronomical Station data. When reconstructing AR from SN, it is taken into account that the function AR = f(SN) has a non-linear systematic character and uncertainty associated with the heterogeneity of these indices. Therefore, in addition to modelling the most probable AR values, predictive limits of reconstruction uncertainty are determined. In the interval 1610–1699 we carried out the reconstruction on the basis of the GN series using the previously proposed decomposition in pseudo-phase space (DPS) method. The resulting series NO21y is freely available online. We show that for this series the empirical Gnevyshev–Ohl rule and Waldmeier effect are fulfilled. Wavelet analysis reveals periodicities of 8.4–13.8 yr for the main cycle (with a sharp decrease of the period before the global Maunder and Dalton minima) and a two-component Gleissberg cycle with typical periods of 50–60 and 90–110 yr.
The iron yield of normal Type II supernovae
Authors: Rodríguez Ó , Meza N , Pineda-García J , Ramirez M 
Published: May 2021

ABSTRACT
We present 56Ni mass estimates for 110 normal Type II supernovae (SNe II), computed here from their luminosity in the radioactive tail. This sample consists of SNe from the literature, with at least three photometric measurements in a single optical band within 95–320 d since explosion. To convert apparent magnitudes to bolometric ones, we compute bolometric corrections (BCs) using 15 SNe in our sample having optical and near-IR photometry, along with three sets of SN II atmosphere models to account for the unobserved flux. We find that the I- and i-bands are best suited to estimate luminosities through the BC technique. The 56Ni mass distribution of our SN sample has a minimum and maximum of 0.005 and 0.177 M⊙, respectively, and a selection-bias-corrected average of 0.037 ± 0.005 M⊙. Using the latter value together with iron isotope ratios of two sets of core-collapse (CC) nucleosynthesis models, we calculate a mean iron yield of 0.040 ± 0.005 M⊙ for normal SNe II. Combining this result with recent mean 56Ni mass measurements for other CC SN subtypes, we estimate a mean iron yield &lt;0.068 M⊙ for CC SNe, where the contribution of normal SNe II is &gt;36 per cent. We also find that the empirical relation between 56Ni mass and steepness parameter (S) is poorly suited to measure the 56Ni mass of normal SNe II. Instead, we present a correlation between 56Ni mass, S, and absolute magnitude at 50 d since explosion. The latter allows to measure 56Ni masses of normal SNe II with a precision around 30 per cent.
Detecting general relativistic orbital precession in transiting hot Jupiters
Authors: Antoniciello G , Borsato L , Lacedelli G , Nascimbeni V , Barragán O , Claudi R 
Published: May 2021

ABSTRACT
Both classical and relativistic weak-field and slow-motion perturbations to planetary orbits can be treated as perturbative corrections to the Keplerian model. In particular, tidal forces and General Relativity (GR) induce small precession rates of the apsidal line. Accurate measurements of these effects in transiting exoplanets could be used to test GR and to gain information about the planetary interiors. Unfortunately, models for transiting planets have a high degree of degeneracy in the orbital parameters that, combined to the uncertainties of photometric transit observations, results in large errors on the determinations of the argument of periastron and precludes a direct evaluation of the apsidal line precession. Moreover, tidal and GR precession time-scales are many order of magnitudes larger than orbital periods, so that on the observational time-spans required to cumulate a precession signal enough strong to be detected, even small systematic errors in transit ephemerides add up to cancel out the tiny variations due to precession. Here we present a more feasible solution to detect tidal and GR precession rates through the observation of variations of the time interval (Δτ) between primary and secondary transits of hot Jupiters and propose the most promising target for such detection, WASP-14 b. For this planet we expect a cumulated $\Delta \tau \, \approx$ −250 s, due to tidal and relativistic precession, since its first photometric observations.
Axis axis(Artiodactyla: Cervidae)
Authors: Randel Charles J , Tomeček John M 
Published: May 2021

AbstractAxis axis (Erxleben, 1777) is an Old World deer commonly known as chital, Indian spotted deer, or axis deer. It is one of five species in the genus Axis and is native to the Indian subcontinent, occurring in India, Nepal, Bhutan, Bangladesh, and Sri Lanka. Free-ranging and confined populations of A. axis have been established in Europe, Australia, and both North and South America. Globally, it is considered “Least Concern” (LC) by the International Union for Conservation of Nature and Natural Resources.
GPCRsignal: webserver for analysis of the interface between G-protein–coupled receptors and their effector proteins by dynamics and mutations
Authors: Miszta Przemysław , Pasznik Paweł , Niewieczerzał Szymon , Jakowiecki Jakub , Filipek Sławomir 
Published: May 2021

Abstract
GPCRsignal (https://gpcrsignal.biomodellab.eu/) is a webserver devoted to signaling complexes of G-protein–coupled receptors (GPCRs). The recent improvement in cryo-electron microscopy resulted in the determination of a large number of high-resolution structures of GPCRs bound to their effector proteins: G proteins or arrestins. Analyzing the interfaces between receptor and an effector protein is of high importance since a selection of proper G protein or specific conformation of arrestin leads to changes of signaling that can significantly affect action of drugs. GPCRsignal provides a possibility of running molecular dynamics simulations of all currently available GPCR-effector protein complexes for curated structures: wild-type, with crystal/cryo-EM mutations, or with mutations introduced by the user. The simulations are performed in an implicit water-membrane environment, so they are rather fast. User can run several simulations to obtain statistically valid results. The simulations can be analyzed separately using dynamic FlarePlots for particular types of interactions. One can also compare groups of simulations in Interaction frequency analysis as HeatMaps and also in interaction frequency difference analysis as sticks, linking the interacting residues, of different color and size proportional to differences in contact frequencies.
Human prefoldin modulates co-transcriptional pre-mRNA splicing
Authors: Payán-Bravo Laura , Fontalva Sara , Peñate Xenia , Cases Ildefonso , Guerrero-Martínez José Antonio , Pareja-Sánchez Yerma , Odriozola-Gil Yosu , Lara Esther , Jimeno-González Silvia , Suñé Carles , Muñoz-Centeno Mari Cruz , Reyes José C , Chávez Sebastián 
Published: May 2021

Abstract
Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin have been described, including a positive contribution to transcription elongation and chromatin dynamics in yeast. Here we show that prefoldin perturbations provoked transcriptional alterations across the human genome. Severe pre-mRNA splicing defects were also detected, particularly after serum stimulation. We found impairment of co-transcriptional splicing during transcription elongation, which explains why the induction of long genes with a high number of introns was affected the most. We detected genome-wide prefoldin binding to transcribed genes and found that it correlated with the negative impact of prefoldin depletion on gene expression. Lack of prefoldin caused global decrease in Ser2 and Ser5 phosphorylation of the RNA polymerase II carboxy-terminal domain. It also reduced the recruitment of the CTD kinase CDK9 to transcribed genes, and the association of splicing factors PRP19 and U2AF65 to chromatin, which is known to depend on CTD phosphorylation. Altogether the reported results indicate that human prefoldin is able to act locally on the genome to modulate gene expression by influencing phosphorylation of elongating RNA polymerase II, and thereby regulating co-transcriptional splicing.
Reactor-based boron neutron capture therapy for 44 cases of recurrent and refractory high-grade meningiomas with long-term follow-up
Authors: Takai Satoshi , Wanibuchi Masahiko , Kawabata Shinji , Takeuchi Koji , Sakurai Yoshinori , Suzuki Minoru , Ono Koji , Miyatake Shin-Ichi 
Published: May 2021

Abstract

Background
High-grade meningioma (HGM) is difficult to treat, and recurrent HGM after radiotherapy has an especially poor prognosis. We retrospectively analyzed the cases of 44 consecutive patients with recurrent and refractory HGM who were treated by reactor-based boron neutron capture therapy (BNCT).

Methods
In 2005–2019, we treated 44 recurrent and refractory HGMs by reactor-based BNCT. We analyzed the patients’ tumor shrinkage, overall survival (OS) after initial diagnosis, OS after BNCT, progression-free survival (PFS) post-BNCT, and treatment failure patterns.

Results
The median OS (mOS) after BNCT and mOS after initial diagnosis were 29.6 (95% CI: 16.1–40.4) and 98.4 (95% CI: 68.7–169.4) months, respectively. The median follow-up after BNCT was 26 (6.4–103) months. The grade 2 (20 cases) and 3 (24 cases) post-BNCT mOS values were 44.4 (95% CI: 27.4–not determined) and 21.55 (10.6–30.6) months, respectively (P = .0009). Follow-up images were obtained from 36 cases at &gt;3 months post-BNCT; 35 showed tumor shrinkage during the observation period. The post-BNCT median PFS (mPFS) of 36 cases was 13.7 (95% CI: 8.3–28.6) months. The post-BNCT mPFS values in patients with grade 2 and 3 disease were 24.3 (95% CI: 9.8–not determined) and 9.4 (6.3–14.4) months, respectively (P = .0024). Local recurrence was observed in only 22.2% of cases. These results showed good local tumor control and prolonged survival for recurrent HGM cases.

Conclusions
Most of these cases had relatively large tumor volumes. The proportion of grade 3 patients was extremely high. Our patients thus seemed to have poor prognoses. Nevertheless, reactor-based BNCT exerted relatively good local control and favorable survival for recurrent and refractory HGMs.
Impact of Anterior Clinoidectomy on Visual Function After Paraclinoid Carotid Artery Aneurysm Surgery: Power-Drill Versus No-Drill Technique
Authors: Niibo Takeya , Takizawa Katsumi , Sakurai Jurou , Takebayashi Seizi , Koizumi Hiroyasu , Kobayashi Toru , Kobayashi Rina , Kuris Kouta , Gotou Syusuke , Tsuchiya Ryousuke , Kamiyama Hiroyasu 
Published: May 2021

ABSTRACT

BACKGROUND
Few studies have attempted to make a direct comparison of the risk of visual impairment following extradural anterior clinoidectomy (EAC) with and without the use of a power drill.

OBJECTIVE
To evaluate postoperative visual outcomes between groups of patients with paraclinoid carotid artery aneurysms (PCAAs) who underwent surgical clipping with and without the use of a power drill during EAC.

METHODS
Between January 2010 and November 2019, 90 patients, 7 with ruptured and 83 with unruptured PCAAs, underwent clipping surgery at our hospital. The authors retrospectively analyzed postoperative visual complications from the medical records of these patients.

RESULTS
Among the 85 patients (excluding 3 patients with disturbance of consciousness caused by subarachnoid hemorrhage and 2 patients with preoperative visual disturbance) evaluated, EAC was conducted using a power drill in 64 patients and using a microrongeur in 21 patients. Permanent postoperative visual impairment developed in 14 (21.9%) patients in the drill group: 9 patients had ipsilateral lower nasal quadrant hemianopsia (ILNQH) and 5 patients had ipsilateral visual acuity reduction. Transient ILNQH developed in only 1 patient in the no-drill group. The incidence of permanent postoperative visual impairments was significantly lower in the no-drill group than in the drill group (P = .020). Seventeen (26.6%) patients developed transient oculomotor nerve palsy in the drill group, while no patients developed oculomotor nerve palsy in the no-drill group.

CONCLUSION
EAC using a microrongeur versus a power drill significantly improved visual outcomes after clipping surgery for PCAAs.
Achieving High Poliovirus Antibody Seroprevalence in Areas at Risk of Vaccine-Derived Poliovirus Transmission—Niger Experience
Authors: Ousmane Sani , Ibrahim Dan Dano , Goel Ajay , Hendley William S , Mainou Bernardo A , Palmer Tess , Diaha Aissata , Greene Sharon A , Mach Ondrej 
Published: May 2021

Abstract

Background
Outbreaks of vaccine-derived poliovirus type 2 (VDPV2) continue to expand across Africa. We conducted a serological survey of polio antibodies in high–polio risk areas of Niger to assess risk of poliovirus outbreaks.

Methods
Children between 1 and 5 years of age were enrolled from structures randomly selected using satellite imaging enumeration in Diffa Province, Niger, in July 2019. After obtaining informed consent, dried blood spot cards were collected. Neutralizing antibodies against 3 poliovirus serotypes were detected using microneutralization assay at the Centers for Disease Control and Prevention.

Results
We obtained analyzable data from 309/322 (95.9%) enrolled children. Seroprevalence of polio antibodies was 290/309 (93.9%), 272/309 (88.0%), and 254/309 (82.2%) for serotypes 1, 2, and 3, respectively. For serotypes 1 and 2, the seroprevalence did not significantly change with age (P = .09 and P = .44, respectively); for serotype 3, it increased with age (from 65% in 1–2-year-olds to 91.1% in 4–5-year olds; P &lt; .001). We did not identify any risk factors for type 2 seronegativity.

Conclusions
With type 2 seroprevalence close to 90%, the risk of emergence of new cVDPV2 outbreaks in Niger is low; however, the risk of cVDPV2 importations from neighboring countries leading to local transmission persists. Niger should maintain its outbreak response readiness capacity and further strengthen its routine immunization.
The e-Banknote as a ‘Banknote’: A Monetary Law Interpreted
Authors: Geva Benjamin , Grünewald Seraina Neva , Zellweger-Gutknecht Corinne 
Published: May 2021

Abstract
This article discusses whether electronic banknotes can properly be characterised as ‘banknotes’, their design as such and what architectural models are available for their issuance by central banks. Issues are addressed under general principles governing the interpretation of monetary laws in the context of evolving technologies and institutional arrangements. The article proposes a clear terminology to address the concepts underlying digital currencies and access to central bank money, and argues that a banknote may be ‘written’ electronically. The stance adopted in the article is critical of both account-based retail central bank digital currency and cryptocurrencies, and highlights the salient features of non-blockchain token-based alternatives. It sheds light on the considerations that influence the selection of a design that is appropriate from both the functional and legal perspectives.
Intracranial Stenting: Angioplasty Basic Technique, Indications, and Sizing: 2-Dimensional Operative Video
Authors: Dossani Rimal H , Waqas Muhammad , Cappuzzo Justin M , Sonig Ashish , Siddiqui Adnan H , Levy Elad I , Davies Jason M ,   Endovascular Neurosurgery Research Group (ENRG), Arthur Adam , Bain Mark , Bendock Bernard , Jo Binning Mandy , Boulos Alan S , Crowley Webster , Fessler Richard , Grande Andrew , Guterman Lee , Hanel Ricardo , Hoit Daniel , Hopkins L Nelson , Howington Jay , James Robert , Jankowitz Brian , Kan Peter , Khalessi Alex A , Kim Louis , Langer David , Lanzino Giuseppe , Levitt Michael , Levy Elad I , Lopes Demetrius , Mack William , Mericle Robert , Mocco J , Ogilvy Chris , Pandey Aditya , Replogle Robert , Riina Howard , Ringer Andrew , Rodriguez Rafael , Saugaveau Eric , Schirmer Clemens , Siddiqui Adnan H , Spiotta Alex , Sultan Ali , Tawk Rabih , Thomas Ajith , Turner Raymond , Veznedaroglu Erol , Welch Babu , White Jonathan 
Published: May 2021

Abstract
Intracranial atherosclerotic disease (ICAD) is a common cause of stroke. Antiplatelet therapy is the mainstay for symptomatic ICAD treatment. Endovascular management with submaximal angioplasty and/or intracranial stenting is reserved for patients with repeated ischemic events despite optimal medical therapy. We demonstrate intracranial angioplasty and stenting technique, technique indications, and sizing of stent and target vessel diameter. Stenting and angioplasty have been described in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis and Wingspan Stent System Post Market Surveillance trials.
1,2
Submaximal angioplasty has also been described.
3
This patient, who had been on dual antiplatelet therapy for several months, initially presented with occlusion of the left middle cerebral artery M2 inferior division and underwent mechanical thrombectomy with successful reperfusion. Postoperatively, the patient's symptoms did not improve. Medical management was optimized with heparin infusion. However, repeat stroke study demonstrated M2 inferior division reocclusion. A decision was made to proceed with intracranial angioplasty and stenting. P2Y12 levels were therapeutic. Under moderate conscious sedation, submaximal angioplasty of up to 80% of the normal M2 caliber was attempted. However, we observed persistent high-grade stenosis of the M2 inferior division. The major risk of crossing the lesion for angioplasty is vessel perforation. To safely perform this maneuver, we used a J-configured Synchro-2 microwire (Stryker). Because of the patient's recent thrombectomy, we also had prior tactile feedback about how much resistance was encountered while crossing the occlusion. We then deployed a balloon-mounted intracranial stent for optimal radial force across the stenotic area to restore perfusion. Postoperative computed tomography perfusion showed resolution of the previously noticed perfusion deficit.
The patient gave informed consent for the procedures and video recording. Institutional review board approval was deemed unnecessary.
Video. ©University at Buffalo Neurosurgery, September 2020. With permission.
Wildfire smoke affects detection of birds in Washington State
Authors: Sanderfoot Olivia V , Gardner Beth 
Published: May 2021

AbstractWildfire smoke is likely to have direct health effects on birds as well as influence movement, vocalization, and other avian behaviors. These behavioral changes may affect if and how birds are observed in the wild, although research on the effects of wildfire smoke on bird behavior is limited. To evaluate how wildfire smoke affects detection of birds, we combined data from eBird, an online community science program, with data from an extensive network of air quality monitors in the state of Washington over a 4-year period. We assessed how PM2.5, a marker of smoke pollution, affected the probability of observing 71 bird species during the wildfire seasons of 2015–2018 using bird observations from 62,908 eBird checklists. After accounting for habitat, weather conditions, seasonality, and survey effort, we found that PM2.5 affected the probability of observing 37% of study species. The ambient concentration of PM2.5 was negatively associated with the probability of observing 16 species and positively associated with the probability of observing 10 species, indicating that birds exhibit species-specific behavioral changes during wildfire smoke events that influence how they are observed. Our results suggest that wildfire smoke impacts the presence, availability, and/or perceptibility of birds. Impacts of smoke pollution on human observers, such as impaired visibility, may also influence detection of birds. These results provide a foundation for developing mechanistic hypotheses to explain how birds, and our studies of them, are impacted by wildfire smoke. Given the projected increase in large-scale wildfire smoke events under future climate change scenarios, understanding how birds are affected by wildfire smoke—and how air pollution may influence our ability to detect them—are important next steps to inform wildlife research and avian conservation.
Temperature and vegetation complexity structure mixed-species flocks along a gradient of elevation in the tropical Andes
Authors: Montaño-Centellas Flavia A , Jones Harrison H 
Published: May 2021

AbstractMixed-species flocks constitute community modules that can help test mechanisms driving changes to community composition across environmental gradients. Here, we examined elevational patterns of flock diversity (species richness, taxonomic diversity, species, and guild composition) and asked if these patterns were reflections of the full bird community at a given elevation (open-membership hypothesis), or if they were instead structured by environmental variables. We surveyed both the overall avian community and mixed-species flocks across an undisturbed elevational gradient (~1,350–3,550 m) in the Bolivian Andes. We then tested for the role of temperature (a surrogate for abiotic stress), resource diversity (arthropods, fruits), and foraging niche diversity (vegetation vertical complexity) in structuring these patterns. Patterns for the overall and flocking communities were similar, supporting our open-membership hypothesis that Andean flocks represent dynamic, unstructured aggregations. Membership openness and the resulting flock composition, however, also varied with elevation in response to temperature and vegetation complexity. We found a mid-elevation peak in flock species richness, size, and Shannon’s diversity at ~2,300 m. The transition of flocking behavior toward a more open-membership system at this elevation may explain a similar peak in the proportion of insectivores joining flocks. At high elevations, increasing abiotic stress and decreasing fruit diversity led more generalist, gregarious tanagers (Thraupidae) to join flocks, resulting in larger yet more even flocks alongside a loss of vegetation structure. At lower elevations, flock species richness increased with greater vegetation complexity, but a greater diversity of foraging niches resulted in flocks that were more segregated into separate canopy and understory sub-types. This segregation likely results from increased costs of interspecific competition and activity matching (i.e., constraints on movement and foraging rate) for insectivores. Mid-elevation flocks (~2,300 m) seemed, therefore, to benefit from both the open-membership composition of high-elevation flocks and the high vegetation complexity of mid- and low-elevation forests.