bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refractory epistaxis and Stamm's S-point
Authors: Kosugi Eduardo Macoto , Balsalobre Leonardo , Stamm Aldo Cassol 
Published: November 2021

Purpose of review
Ethmoidal arteries are gaining increasing importance as the main source of severe refractory epistaxis. In this direction, Stamm's S-point, a specific bleeding point in the upper nasal septum, around the projection of the axilla of middle turbinate, posterior to the septal body, was recently described. The aim of this review was to present recent data on S-point and its role in severe refractory epistaxis.

Recent findings
Due to the hidden location posterior to the septal body, S-point is not easily identified by anterior rhinoscopy. When systematic endoscopic assessment was performed in severe epistaxis to search for the precise bleeding point, S-point was clearly the most identified (23.7–28.3%). Electrocauterization of bleeding point had high success rates (91.5–100%) and decreased the risk of recurrence bleeding.

Summary
Stamm's S-point plays an important role in severe refractory epistaxis, due to its frequency and stability. However, this specific bleeding point could not be easily identified, so systematic endoscopic assessment should be performed. Recent data has shifted the paradigm of the main source of severe epistaxis from the sphenopalatine artery to ethmoidal arteries and presented high success rates for electrocauterization of bleeding points as single treatment of severe epistaxis.
Adverse Drug Reactions at Nonelective Hospital Admission in Children and Adolescents: Comparison of 4 Causality Assessment Methods
Authors: Neininger Martina Patrizia , Wehr Raphaela , Kiesel Lisa Marie , Neubert Antje , Kiess Wieland , Bertsche Astrid , Bertsche Thilo 
Published: November 2021

Objectives
This study aimed to compare assessment methods to determine adverse drug reactions (ADRs) at nonelective hospital admission in pediatric patients, to investigate the interrater reliability of assessment methods in pediatric care, and to analyze symptoms related to ADRs and (suicidal) drug intoxications.

Methods
For 1 year, the medical records of nonelective patients admitted to a university pediatric department were evaluated for potential ADRs using 4 assessments methods by 1 experienced rater. Krippendorff α was calculated from a sample of 14 patients evaluated by 4 experienced raters to determine interrater reliability.

Results
In 1831 nonelective hospital admissions, 63.4% (1161 of 1831) of patients had received at least one drug before admission. We found a potential causal relationship between drugs and symptoms documented at admission and thus potential ADRs according to Naranjo in 23.3% (271 of 1161) of those patients, World Health Organization - Uppsala Monitoring Centre (WHO-UMC) in 22.5% (261 of 1161), Koh in 21.7% (252 of 1161), and Begaud in 16.5% (192 of 1161). The probability rating of the potential causal relationships varied considerably between the methods (Naranjo-Begaud, P < 0.01; Naranjo-Koh, P < 0.001; Koh-Begaud, P < 0.01; Begaud-WHO-UMC, P < 0.01). Acceptable interrater reliability (α ≥ 0.667) was only obtained for WHO-UMC (α = 0.7092). The most frequently identified definite ADR was sedation in 1.5% of all nonelective patients with medication before hospital admission. In 1.2% (22 of 1831) of all nonelective admissions, we found drug intoxications with suicidal intent.

Conclusions
The assessment methods showed a high variability in the determination of a potential causal relationship between drug and documented symptom, in the classification of the probability of ADRs, and suboptimal interrater reliability. Thus, their feasibility in pediatric patients is limited.
Adenosine, lidocaine, and magnesium for attenuating ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta in a porcine model
Authors: Franko Jace J. , Vu Michael M. , Parsons Michael E. , Conner Jeffrey R. , Lammers Daniel T. , Ieronimakis Nicholas , Reynolds Gregory D. , Eckert Matthew J. , Bingham Jason R. 
Published: November 2021

BACKGROUND
Minimally invasive resuscitative endovascular balloon occlusion of the aorta (REBOA) following noncompressible hemorrhage results in significant ischemia reperfusion injury (IRI). Adverse outcomes from IRI include organ dysfunction and can result in profound hemodynamic and molecular compromise. We hypothesized that adenosine, lidocaine, and magnesium (ALM) attenuates organ injury and inflammation responses following REBOA IRI in a porcine model of hemorrhage.

METHODS
Animals underwent a 20% controlled hemorrhage followed by 45 minutes of supraceliac balloon occlusion. They were randomized into two groups: control (n = 9) and ALM intervention (n = 9) to include a posthemorrhage, pre-REBOA bolus (200 mL of 3% NaCl ALM) followed by a continuous drip (2 mL/kg per hour of 0.9% NaCl ALM) during the 4-hour resuscitative period. Primary outcomes included hemodynamic parameters, gene expression of inflammatory signaling molecules, and plasma concentrations of select cytokines and chemokines.

RESULTS
The ALM cohort demonstrated a significant reduction in cardiac output and cardiac index. Plasma concentrations of interleukin 2 and interleukin 10 were significantly lower 3 hours post-REBOA in animals treated with ALM versus vehicle. Interleukin 4 levels in plasma were also lower with ALM at 3 and 4 hours post-REBOA (p < 0.05). Liver expression of IL1RN, MTOR, and LAMP3 messenger RNA was significantly lower with ALM as compared with the vehicle. No significant difference in large bowel gene expression was observed between treatments.

CONCLUSION
In a porcine model of hemorrhage, ALM treatment mitigated inflammatory responses early during post-REBOA resuscitation. Our findings suggest that ALM use with trauma may reduce inflammatory injury and improve outcomes related to REBOA utilization.
Circ_HECTD1 regulates cerebral ischemia injury via mechanisms involving the regulation of let-7c-5p/ROCK1 axis
Authors: Guo Qian , Guo Tingting , Sun Yuanyuan , Chen Tianrong 
Published: November 2021

Background
Ischemia is the main cause of cerebral ischemic stroke with a high mortality rate, and it is affected by the dysfunction of circular RNAs. The underlying molecular mechanisms of circ_HECTD1 were explored in cerebral ischemia stroke.

Methods
PC-12 cells were treated with oxygen-glucose deprivation/reoxygenation (OGD/R) as the cell model of cerebral ischemia model. The expression levels of circ_HECTD1, let-7c-5p, and Rho-associated coiled-coil-containing protein kinase 1 (ROCK1) were determined by quantitative real-time PCR in PC-12 cells. The proliferation ability of PC-12 cells was assessed by 5-ethynyl-2’-deoxyuridine and 3-(4,5-dimethylthizol-2-yl)-2,5-diphenyltetrazolium bromide assays. The protein expression levels were quantified by western blot analysis. Flow cytometry was performed to analyze cell apoptosis. Lactate dehydrogenase concentration was assessed by a commercialized kit. Dual-luciferase reporter assay was used to confirm the interaction relationships among circ_HECTD1, let-7c-5p and ROCK1.

Results
Circ_HECTD1 was upregulated in OGD/R-treated PC-12 cells. The results also showed that cell proliferation was decreased and apoptosis was increased in OGD/R-treated PC-12 cells, which was overturned by the inhibition of circ_HECTD1. Let-7c-5p was a target of circ_HECTD1, and the protective effects of circ_HECTD1 knockdown on OGD/R-treated PC-12 cells were canceled after co-transfection with let-7c-5p inhibitor. We found that ROCK1 was a potential target of let-7c-5p. Let-7c-5p -mediated the effects on the proliferation and apoptosis of OGD/R-treated PC-12 cells by targeting ROCK1.

Conclusion
Circ_HECTD1 was implicated in the development of cerebral ischemia stroke. Knockdown of circ_HECTD1 protected against cerebral ischemia injury in OGD/R-treated PC-12 cells depending on the regulation of let-7c-5p/ROCK1 axis.
Low-temperature investigation of natural iron-rich oxoborates vonsenite and hulsite: thermal deformations of crystal structure, strong negative thermal expansion and cascades of magnetic transitions
Authors: Biryukov Yaroslav P. , Zinnatullin Almaz L. , Cherosov Mikhail A. , Shablinskii Andrey P. , Yusupov Roman V. , Bubnova Rimma S. , Vagizov Farit G. , Filatov Stanislav K. , Avdontceva M. S. , Pekov Igor V. 
Published: November 2021

This work is devoted to an investigation of the magnetic properties and thermal behaviour of the natural oxoborates vonsenite and hulsite in the temperature range 5–500 K. The local environment, the oxidation states of the Fe and Sn atoms, and the charge distribution were determined using Mössbauer spectroscopy and are in accordance with a refinement of the crystal structure of hulsite from single-crystal X-ray diffraction data (SCXRD) in anisotropic approximation for the first time. The magnetic properties were studied by vibrating sample magnetometry (VSM) (5 ≤ T ≤ 400 K) and are reported for the first time for iron-rich hulsite. Both oxoborates show a very complex magnetic behaviour. Cascades of magnetic transitions are revealed and the critical temperatures were determined. The sequences of magnetic transitions in both vonsenite and hulsite with increasing temperature were found to be as follows: magnetically ordered state → partial magnetic ordering → paramagnetic state. According to X-ray diffraction data (93 ≤ T ≤ 500 K), these processes are accompanied by anomalies in the unit-cell parameters and thermal expansion of the oxoborates at critical temperatures. A strong negative volume thermal expansion is observed for both oxoborates at temperatures below ∼120 K.
Hunting and raising livestock are associated with meat-related attitudes, norms and frequent consumption: implications for dietary guidance to rural residents
Authors: Linville Twila , Hanson Karla L. , Sobal Jeffery 
Published: November 2021

PurposeMeat consumption is higher than health recommendations, but little is known about potential moderating factors in rural areas. Informed by the theory of planned behaviour (TPB), this paper explored potential moderators amongst rural residents.Design/methodology/approach The authors summarized meat-related attitudes (importance, taste preference, healthfulness perceptions), social norms, controls (availability, affordability, self-efficacy) and frequency of consumption (overall, lean meat, wild game) in a cross-sectional survey of rural, adult, US volunteers (n = 572). The authors examined correlations and differences by gender, connection to hunting and to livestock raising.Findings These rural residents had positive attitudes toward meat, high family expectations to consume meat and daily consumption. Half of the meat consumed was lean but was infrequently wild game. Respondents with connections to hunting or raising livestock reported more positive meat-related attitudes, norms and self-efficacy, and more frequent meat consumption. Those with a connection to hunting also had higher perceived availability, affordability and consumption of wild game.Research limitations/implications Strong meat preferences and expectations may hamper moderation amongst rural residents, particularly in households connected to hunting or raising livestock. Dietary advice can be tailored to respect meat consumption, emphasize the identification and selection of lean meats and highlight wild game as a lean meat that is moderately available and affordable. Future research should disentangle hunting and livestock raising as potential factors in food choice and examine wild game consumption in jurisdictions where it can be sold legally.Originality/value This study was novel in examining meat-related practices amongst rural residents, separately examining lean meats and wild game, and identifying hunting and livestock raising as important predictors.
Process maturity and patient orientation in times of a health system reform
Authors: Bogodistov Yevgen , Moormann Jürgen , Sibbel Rainer , Krupskyi Oleksandr P. , Hromtseva Olena 
Published: November 2021

PurposeThis study investigates the impact of the degree of process maturity on the degree of patient orientation in the context of radical process changes. The study is based on a sample of healthcare providers in Ukraine which experiences a fundamental transformation of its healthcare system.Design/methodology/approachThe investigation was conducted among the full population of the chief physicians from 53 medical institutions (hospitals, general practitioners centers, dental clinics, and maternity clinics) in one of the largest cities in Ukraine. We investigated the maturity of the process of interaction with patients as perceived by these top managers. We applied variance-based structural equation modeling (SmartPLS3).FindingsThe study shows that each stage of process maturity predetermines the following one. With regard to the impact of each stage of process maturity on patient orientation, all stages show a positive and significant relationship toward patient orientation, i.e. even the lowest stage of maturity is critical for patient orientation. A further contradictory finding to extant literature is, that based on the set of indicators, the process appears to be in different stages at the same time. This speaks against the regular sequence-based approach toward process maturity.Originality/valueAlthough it has been assumed that higher degrees of process maturity are associated with higher customer (patient) orientation, this work shows that the relationship holds also for each stage of process maturity separately. This research is based on a very unique sample – the almost complete set of chief physicians and their deputies of practically all medical institutions of a large city.
Energy and time-efficient circuitry of bat-bootstrap and comp-lifier for ultra-low power SAR-ADC
Authors: Faheem Muhammad Yasir , Zhong Shun'an , Azeem Muhammad Basit , Wang Xinghua 
Published: November 2021

Purpose
Successive Approximation Register-Analog to Digital Converter (SAR-ADC) has been achieved notable technological advancement since the past couple of decades. However, it’s not accurate in terms of size, energy, and time consumption. Many projects proposed to make it energy efficient and time-efficient. Such designs are unable to deliver two parallel outputs.

Design/methodology/approach
To this end, this study introduced an ultra-low-power circuitry for the two blocks (bootstrap and comparator) of 11-bit SAR-ADC. The bootstrap has three sub-parts: back-bone, left-wing and right-wing, named as bat-bootstrap. The comparator block has a circuitry of the two comparators and an amplifier, named as comp-lifier. In a bat-bootstrap, the authors plant two capacitors in the back-bone block to avoid the patristic capacitance. The switching system of the proposed design highly synchronized with the short pulses of the clocks for high accuracy. This study simulates the proposed circuits using a built-in Cadence 90 nm Complementary Metal Oxide Semiconductor library.

Findings
The results suggested that the response time of two bat-bootstrap wings and comp-lifier are 80 ns, 120 ns, and 90 ns, respectively. The supply voltage is 0.7 V, wherever the power consumption of bat-bootstrap, comp-lifier and SAR-ADC are 0.3561µW, 0.257µW and 35.76µW, respectively. Signal to Noise and Distortion Ratio is 65 dB with 5 MHz frequency and 25 KS/s sampling rate. The input referred noise of the amplifier and two comparators are 98µVrms, 224µVrms and 224µVrms, respectively.

Originality/value
Two basic circuit blocks for SAR-ADC are introduced, which fulfill the duality approach and delivered two outputs with highly synchronized clock pulses. The circuit sharing concept introduced for the high performance SAR-ADCs.
Solving binary programming problems using homotopy theory ideas
Authors: Alanís-López Lilia , Casas-Ramírez Martha-Selene , Camacho-Vallejo José-Fernando 
Published: November 2021

PurposeThe aim of the study is to show that merging two areas of mathematics – topology and discrete optimization – could result in a viable option to solve classical or specialized integer problems.Design/methodology/approachIn the paper, discrete topology concepts are applied to propose a metaheuristic algorithm that is capable to solve binary programming problems. Particularly, some of the homotopy for paths principles are used to explore the solution space associated with four well-known NP-hard problems herein considered as follows: knapsack, set covering, bi-level single plant location with order and one-max.FindingsComputational experimentation confirms that the proposed algorithm performs in an effective manner, and it is able to efficiently solve the sets of instances used for the benchmark. Moreover, the performance of the proposed algorithm is compared with a standard genetic algorithm (GA), a scatter search (SS) method and a memetic algorithm (MA). Acceptable results are obtained for all four implemented metaheuristics, but the path homotopy algorithm stands out.Originality/valueA novel metaheuristic is proposed for the first time. It uses topology concepts to design an algorithmic framework to solve binary programming problems in an effective and efficient manner.
Blow the whistle or dance to a tune! An ethical dilemma
Authors: Qazi Asad Ali , Shaikh Abdul Rehman , Appolloni Andrea 
Published: November 2021

Case overview
Mr Qazi was sitting in his office in the Multan branch, reviewing his past month’s key performance indicators when he got a call from his Town Operations Supervisor, Mr Ahmed, based in Bahawalpur. Ahmed was recently promoted and transferred to Bahawalpur, from Multan branch. He informed Qazi about the huge inventory variances, which were not earlier reported by the previous Town Operations Supervisor, Mr Sagheer. Qazi was informed that differences were around 2.37% of total sales vs the allowable company limit of Zero inventory variance. Qazi was worried about whether to report these differences to higher management or not. He was very well aware that reporting might even cost him his job, and that of Sagheer too. He could not see any solution to the recovery of the inventory or cash against the same. Should Qazi take a risk and let go of Sagheer? Should he report the differences?

Expected learning outcome
1. Demonstrate the fraud and integrity-related issues. Why and how happened? 2. Analyzed the role of organizational policies in the decision of blow the whistle. 3. Identify the behaviors that helped a whistle-blower. 4. Assess the ethical dilemmas in which professional duties may conflict with personal ethics. 5. Propose organizational policies to encourage whistle-blowing and to discourage the fraud or integrity-related issues.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 9: Operations and logistics.

Study level/applicability
BBA.
A switch from flipped classrooms to emergency remote online teaching (EROT): misconceptions, instructors and preservice teachers perceptions
Authors: Ironsi Chinaza Solomon 
Published: November 2021

PurposeThis study intends to examine these misconceptions in a bid to reaching a valid conclusion. More importantly, this study intends to elicit information from instructors and preservice teachers on their experiences, successes and challenges on the sudden switch from flipped classroom to emergency remote online teaching.Design/methodology/approachThe study adopted a qualitative research design and the main focus of this research design which was is a form of exploratory research design was to understand the reasons opinions and viewpoints of a particular group of people concerning a situation. This paper deems this research design fit for eliciting relevant information from instructors and preservice teachers on their opinions and perceptions on the sudden shift from flipped classrooms to emergency remote online teaching during the previous semester. Data collection for this study was carried out through the use of focus group discussions where participants were asked questions based on the objective of the study.FindingsThe present findings confirm that the mode of instruction delivery was not online teaching rather emergency remote online teaching. Another conclusion that was drawn was with regards to training, use of resources and issues of measurement and evaluation. The study summarized that there was little or no training for the teaching staff before the switch to EROT as instructors were only given guidelines on what to do to implement their lesson plans.Originality/valueEmergency remote online teaching is a newly emerging approach to lesson delivery, especially in an emergency situation. This study elaborates more on this new dimension of teaching and future prospects as well.
A novel, low-cost technique for modelless calibration of a 3-axis parallel kinematic machine
Authors: Tipary Bence , Erdős Ferenc Gábor 
Published: November 2021

Purpose
The purpose of this paper is to propose a novel measurement technique and a modelless calibration method for improving the positioning accuracy of a three-axis parallel kinematic machine (PKM). The aim is to present a low-cost calibration alternative, for small and medium-sized enterprises, as well as educational and research teams, with no expensive measuring devices at their disposal.

Design/methodology/approach
Using a chessboard pattern on a ground-truth plane, a digital indicator, a two-dimensional eye-in-hand camera and a laser pointer, positioning errors are explored in the machine workspace. With the help of these measurements, interpolation functions are set up per direction, resulting in an interpolation vector function to compensate the volumetric errors in the workspace.

Findings
Based on the proof-of-concept system for the linear-delta PKM, it is shown that using the proposed measurement technique and modelless calibration method, positioning accuracy is significantly improved using simple setups.

Originality/value
In the proposed method, a combination of low-cost devices is applied to improve the three-dimensional positioning accuracy of a PKM. By using the presented tools, the parametric kinematic model is not required; furthermore, the calibration setup is simple, there is no need for hand–eye calibration and special fixturing in the machine workspace.