bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary source of Vitamin D: sunlight or nutrition?
Authors: Fikri Bahrul , Juliaty Aidah , Engels Sam , Putera Azwin Mengindera , Hikmah Zahrah , Febriani Andi Dwi Bahagia , Putri Sri Hardiayanti , Ridha Nadirah Rasyid , Alasiry Ema , Endaryanto Anang , Massi Nasrum , Yusrawati  , Irawati Deasy , Kadrian Hamsu 
Published: January 2025

Link of Video Abstract: https://youtu.be/w3EhDrNg4ts

This study reviews the existing literature on whether sunlight or nutrition is the main source of vitamin D and explores the factors contributing to vitamin D deficiency in tropical regions. The key findings include urbanization, ethnicity, sun-avoidance, religion, and nutrition as causes for the high prevalence of vitamin D deficiency in tropical areas. While sunlight is considered the main source of vitamin D, factors such as air pollution, sun-avoidance behaviors, and the clothing style of certain religions can limit sunlight absorption. Moreover, limited access to vitamin D-rich foods and low consumption of fortified foods contribute to the deficiency. The study suggests further research on the role of nutrition as a potential main contributor to vitamin D deficiency in tropical areas.
Comparison outcomes of miniplate and wire cerclage fixation in traumatic sternal fracture: a retrospective multicenter study
Authors: Yasa Ketut Putu , Jiwangga Dhihintia , Sarwono Antonius , Kartika Ronald , Dandanah Maulidya Ayudika , Hatta Hariadi , Sudarma Wayan , Hakim Arif Rahman , Dharmawan Tommy , Ibnu Syahroni 
Published: January 2025

Introduction: The management of traumatic sternal fractures is quite heterogeneous and still has controversies. Open surgical fixation is occasionally indicated for intractable pain, and unstable motion of sternum as a risk factor for respiratory distress. This study aimed to compare the outcome of miniplate and wire cerclage fixation in traumatic sternal fractures.
Methods: A cross-sectional retrospective multicenter study was carried out during 2015 - 2020 in traumatic sternal fracture patients who were undergoing open surgical fixation. Data collection was carried out such as demographic characteristics, associated injury, mechanism of injury, site and type of sternal fracture, the fixation method. Exclusion criteria were sternal fractures due to non-trauma, incomplete data, and patient death or referral to other facilities The primary outcomes endpoints of this study were duration of ventilator after surgery, intensive care unit (ICU) length of stay, hospital length of stay (LOS), and complications of blood loss requiring transfusion. Patients were divided into a miniplate fixation group and wire cerclage fixation group. The comparison outcome between two groups was statistically analyzed using the Mann-Whitney test and Chi-square / Fisher Exact test from numerical and categorical data.
Results: During 2015-2020, 47 traumatic sternal fracture patients were included, but 34 patients were included. Mean age 37 – 42 years, majority of patients were male 31 (91%), 25 (73%) fracture site at corpus sternum, with associated injury 27 (79%) mostly rib fracture (47%) and hemothorax or pneumothorax (56%), mechanism of injury was 30 (88%) of patients were traffic accident. There were 15 (44%) patients who underwent a miniplate fixation and 19 (56%) patients who underwent wiring cerclage fixation. From statistical analyses in both numerical and categorical data showed there was no significant difference outcome between two groups in terms of the length of ventilatory support, ICU LOS, Hospital LOS and blood loss requiring blood transfusion (p>0.05), although that all variables were higher in wire cerclage groups. However, there was a significant difference in the intubation before surgery (p<0.05), this is probably related to the associated injury and presence of displaced and multiple fractures of sternum in wiring group.
Conclusion: There was no significant difference outcome between miniplate compared to wire cerclage fixation in traumatic sternal fractures in duration of ventilatory support, ICU LOS, Hospital LOS and blood loss requiring transfusion, although that all variables were higher in wire cerclage groups. There was a significant difference in intubation before surgery, this is probably related to the associated injury and presence of displaced and multiple fractures of sternum.
Barriers to rabies prevention through canine vaccination in Payangan tourism destination, Bali
Authors: Wijaya Made Indra , Pradnyawati Luh Gede , Juwita Dewa Ayu Putu Ratna , Kartinawati Komang Triyani , Pratiwi Anny Eka 
Published: January 2025

Link of Video Abstract: https://www.youtube.com/watch?v=TjSFVNybRS8&ab_channel=BaliMedicalJournal

Introduction: Rabies was first reported officially in Bali, The Republic of Indonesia, in November 2008. In 2022, primary preventive strategy is implemented through mass canine vaccination, combined with door-to-door canine vaccination. However, until the end of 2022, the outbreak had not been well controlled and unmet canine vaccination coverage is suspected as the culprit of continuing transmission. This study aimed to identify facilitators and barriers to rabies prevention through canine vaccination during mass campaigns in Payangan tourism destination.
Methods: This is a qualitative study. Purposive sampling was used to select informants to be interviewed. Data were collected within 2-30 March 2023 period. The analysis was carried out by inductive coding process. Themes emerged during analysis were categorized into the social ecological model.
Results: We found various barriers in preventing rabies through rabid canine vaccination at the individual, interpersonal, institutional and community levels from a social ecological model.
Conclusion: Our findings revealed that risk communication should be emphasized on improving knowledge about rabid canine. The canine mass vaccination promotion should be conducted in a timely manner. To comprehensively address the barriers to rabies prevention through canine vaccination in tourism destinations, future studies should focus on multifaceted research.
Relationship between the expression of Ki-67 and distant metastases in patients with well-differentiated thyroid cancer
Authors: Khuzaini Khuzaini , Sahudi Sahudi , Susilo Dwi Hari 
Published: January 2025

Link of Video Abstract: https://youtu.be/27JVmnJSgbY

Background: Thyroid carcinoma, which accounts for 1% of all cancers, is the most common malignancy of the endocrine organ and has a high mortality rate. One of the risk factors for prognosis in thyroid carcinoma is distant metastasis and pathological differentiation. Ki-67 is a marker in determining tumor prognosis and determining the rate of recurrence after radiotherapy in patients with carcinoma. This study aims to determine the relationship between Ki-67 expression and distant metastases in well-differentiated thyroid cancer patients at Dr. Soetomo General Hospital Surabaya.
Methods: This is a cross sectional study conducted during May 2022 – June 2023 at Division of Surgery and Anatomical Pathology Department of Dr. Soetomo General Hospital from medical records of thyroid cancer patients with histopathology results of papillary thyroid carcinoma (PTC) or follicular thyroid carcinoma (FTC). The data was then analyzed using the Mann Whitney test.
Results: In bivariate analysis, it was found that the difference between positive and negative distant metastases for Ki-67 was statistically significant (p<0.05), the difference between positive and negative distant metastases for Ki-67 in cases of anatomical pathology samples of Papillary Carcinoma was statistically significant ( p<0.05), and the difference between positive and negative distant metastases for Ki-67 in cases of Follicular Carcinoma anatomical pathology samples was not statistically significant (p=0.480). The accuracy rate for distant metastases with Ki-67 was 76.5% with a cut off value of 6. There was a statistically significant relationship between distant metastases and the value of Ki-67 (P<0.05).
Conclusion: Thyroid cancers with a higher Ki-67 have a much greater chance of metastases compared to those with a lower Ki-67. Ki-67 expression can be a prognostic and diagnostic indicator in well-differentiated thyroid cancer.
Efficacy of synbiotics supplementation in hemodialysis patients with chronic constipation: A randomized controlled trial
Authors: Widiasih Esti , Subagio Hertanto Wahyu , Lestariningsih  
Published: January 2025

Link of Video Abstract: https://youtu.be/b-Xvr4HxEuw

Introduction: Constipation is prevalent in routine hemodialysis patients. Gut-dysbiosis in hemodialysis patients causes increased proteolytic bacterial activity, leading to increased production of uremic toxins and worsening of constipation symptoms. Improvement of gut microbiota dysbiosis is expected to improve this condition. This study aims to evaluate the effect of synbiotics on gut dysbiosis and symptoms of constipation.
Methods: This is a double-blind, randomized control trial, pre-test and post-test design. We included hemodialysis patients with gastrointestinal complaints, difficulty defecating, stools with a hard consistency, or defecation frequency of less than three times per week. Subjects were randomly divided into two groups. The synbiotic group was given twice daily capsules containing Lactobacillus acidophilus, Bifidobacterium longum 5x109 Colony Forming Unit (CFU), and Fructooligosaccharides (FOS) 500 mg, and the control group was given maltodextrin in the same capsule packaging. The intervention was carried out for 45 days. Results were measured using fecal Short Chain Fatty Acid (SCFA) levels to assess gut dysbiosis, the Bristol scale, and the constipation questionnaire to assess the degree of constipation complaints.
Results: We included 46 subjects for both groups. There was a significant increase in the amount of SCFA in the synbiotic group (p=0.01), and there was an improvement in stool consistency (p<0.001) and a significant reduction in the degree of constipation complaints (<0.001) in the synbiotic group compared to the control group.
Conclusion: Synbiotic supplementation for 45 days is efficacious in improving gut dysbiosis stool consistency and reducing the severity of constipation in hemodialysis patients.
Study of effectiveness of chitosan in the process of wound bleeding on Wistar (Rattus novergicus) rats
Authors: Noviana Heri , Saputro Iswinarno Doso , Hariani Lynda 
Published: January 2025

Link of Video Abstract: https://youtu.be/K0slXOP7Ll4

Background: The general way to treat bleeding using topical epinephrine has been widely used, but if there are large capillaries, the effectiveness of epinephrine still needs to be improved, and bleeding still occurs. This study aims to prove the effectiveness of chitosan in treating bleeding compared to epinephrine 1:100,000. This research aimed to know the difference in the efficacy of giving Chitosan compared to Epinephrine 1:100,000 in stopping bleeding.
Methods: This research used an experimental research design, a randomized post-test-only group design. The subjects in this study were mice treated with wounds measuring 3x3 cm on their backs with a full thickness depth (±1.3 mm). A total of 36 consecutive subjects were randomly grouped into two treatment groups: the group given epinephrine and the group given chitosan. The coagulation time in the bleeding wounds of rats in groups 1 and 2 was immediately calculated with a stopwatch after topical epinephrine and chitosan were administered. Then, coagulation was evaluated after 3 minutes.
Results: There was a significant difference (p<0.05 )in the time needed to stop bleeding between the Epinephrine and Chitosan groups, where the time needed to stop bleeding in the Epinephrine group was higher than the Chitosan group.
Conclusion: Chitosan provides a faster cessation of bleeding than epinephrine use in experimental mice with acute wounds.
GPi pallidotomy versus pallidothalamic tractotomy forel h-1 in Parkinson's disease: a systematic review in outcome and complication
Authors: Ismail Arif , Fahmi Achmad , Turchan Agus , Utomo Budi , Fauzi Asra Al , Subianto Heri , Wisnawa I Wayan Weda , Brilliantika Surya Pratama 
Published: January 2025

Link of Video Abstract: https://youtu.be/118qmW5u19E

Background: Parkinson's disease (PD) is a neurodegenerative disorder with the main motor symptoms of tremor, rigidity, bradykinesia/akinesia, and postural instability. Stereotactic brain lesioning is a therapeutic option for Parkinson's disease. The development of imaging modalities, such as MRI, has made Forel H-1 Pallidothalamic Tractotomy begin to be reconsidered as a treatment for Parkinson's disease besides GPi Pallidotomy. This study aims to compare the effectiveness and complications of the two procedures.
Methods: This research is a qualitative analytical study in the form of a systematic review. This research database comes from a literature search in PubMed, Science Direct, and The Cochrane Library with the keywords ((("Parkinson's Disease") OR ("Parkinson") OR ("Parkinsonism") OR ("PD")) AND ("Pallidothalamic Tractotomy") AND ("GPi Palidotomy") AND (("UPDRS") OR ("outcome")). This study used a sampling technique to filter literature search results from Pubmed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis flow. (PRISMA)
Results: This systematic review included 343 patients, with males predominating at 46.9%. The remaining 28.8% were women, and some studies did not explain the gender of the patients. The number of patients who did not have gender data was 24.1%. In this study, the average age was 58.9 ± 7.1 years from 286 patients whose age data was known. The drug most commonly used was levodopa in 271 patients, followed by dopamine agonists in 45 patients, and COMT-inh in 17 patients. The average dose of levodopa used was 7,04.4 ± 257.7 mg. The procedures performed were GPi Pallidotomy in 206 patients, Pallidothalamic Tractotomy in 52 patients, and others in 16. The most widely used approach was the unilateral approach in 268 patients and the bilateral approach in 63 patients. There were improvements in UPDRS I, II, and III scores and total scores in all GPi and PTT cases.
Conclusion: The GPi and PTT methods improve UPDRS I, II, and III scores and total UPDRS scores in PD patients. Permanent complications are more frequently reported in GPi Pallidotomy procedures than PTT procedures.
Corpus alienum in urinary bladder due to Intrauterine Device (IUD) translocation: a case report
Authors: Fadli Muhammad Yogie , Ferdian Vicky 
Published: January 2025

Link of Video Abstract: https://youtu.be/5HVCQHXhpdc

Background: The intrauterine device (IUD) is a widely utilized reversible contraceptive method. While generally considered safe, a rare yet severe complication involves uterine perforation, leading to IUD migration into the abdominal or pelvic organs. Uncommonly, migration of the IUD to the bladder has been reported.
Case Presentation: We present the case of a 47-year-old woman experiencing lower urinary tract symptoms with a 29-year history of IUD insertion. Ultrasonography revealed a hypoechoic shadow within the urinary bladder, indicative of IUD translocation from the uterus, a finding later confirmed by X-ray examination. Remarkably, the IUD surface exhibited stone formation, successfully addressed through cystoscopic extraction.
Conclusion: This case underscores the rare occurrence of IUD migration to the bladder, emphasizing the importance of considering such complications in patients with prolonged IUD use. The successful management of this case through cystoscopic extraction highlights the efficacy of a minimally invasive approach in addressing IUD translocation complications.
Effectiveness of dextrose prolotherapy injection on chronic knee osteoarthritis patients
Authors: Nofiansyah Rian , Susila Dedi , Kriswidyatomo Prihatma , Belindo Wirabuana  
Published: January 2025

Background: Osteoarthritis (OA) of the knee is a chronic, degenerative, and disruptive joint condition that frequently reduces quality of life and imposes a significant socioeconomic burden on patients and caregivers. The purpose of this study is to compare pain scale and functional ratings before and after dextrose prolotherapy injection in individuals with persistent osteoarthritis of the knee.
Methods: This study is an observational analytical study using retrospective data involving 61 samples of patients with a diagnosis of knee osteoarthritis based on the clinical criteria of the American College of Rheumatology who were injected with 20% dextrose prolotherapy 6 ml intra-articularly and 12.5% dextrose 6 ml peri-articularly. Each patient was injected with prolotherapy 4 times with an interval of 2 weeks at the same injection point. Patients were evaluated for pain scale and functional score at pre-injection, 6 weeks, and 20 weeks. All data processing was performed using SPSS version 26, with a significance level (p-value) set at 0.05.
Results: Demographic characteristics of this study: subjects aged 45 to 75 years with an average of 62.38 ± 8.14 years. 85.2% of subjects were female, 67.2% of subjects had a BMI ≥25 kg/m2, and 75.4% of subjects experienced pain for more than 1 year. There was a significant difference in pain scale and functional score (p-value <0.05) at pre-injection compared to 6 weeks and 20 weeks.
Conclusion: Dextrose prolotherapy injection is effective in improving pain and functional improvement in patients with chronic knee osteoarthritis patients.
Evaluation of laboratory parameters in pregnant women with covid-19 infection
Authors: Hadi Cahyono , Purna Anggraini Nutria Widya , Edwin Eric , Savitri Sheila , Purnomo Adi 
Published: January 2025

Introduction: Pregnant women with COVID-19 had clinical and laboratorial differences conditions than non-pregnant women. The pregnant woman with COVID-19 had higher neutrophil rates, lower hemoglobin levels, and an increased risk of preterm birth. This study aimed to determine the relationship between the laboratory parameters of pregnant women in the second first trimester and the third trimester and predict the possibility of requiring intensive care.
Methods: This was a retrospective study that analyzes the laboratory findings that were collected in pregnant patients with COVID-19. Laboratory parameters performed at the beginning of the patient's treatment include hemoglobin, leukocytes, platelets, random blood sugar, serum creatinine, ureum, serum glutamic oxaloacetic transaminases (SGOT), and serum glutamic pyruvic transaminases (SGPT).
Result: Data on 391 pregnant women patients with COVID-19 infection, consisting of 25 first and second trimester patients and 366 third trimester patients. There was an increase in leukocyte values in the I-II trimester group (8%) and the III trimester (10.1%); SGOT in the I-II trimester (32%) and the III trimester (12.3%); and SGPT in the I-II trimester (12%) and III trimester (14%). There were significant variations in the values of hemoglobin (p =0.013), platelet count (p = 0.002) and random blood glucose (p = 0.008). This comparison was not significant enough in distinguishing the laboratory parameters of leukocyte count, SGOT, SGPT, ureum and creatinine in the study group.
Conclusions: Two parameters were consistently significant in both gestational age and ICU treatment. Leukocyte, glucose, and platelets counts showed a higher mean compared to the non-ICU treatment group.
Immediate effect of proprioceptive neuromuscular facilitation stretching of calf muscle on peak plantar pressure in type 2 diabetes mellitus patients with diabetic neuropathy
Authors: Aritonang Ricky Shubhan , Subadi Imam , Pawana I Putu Alit , Mudjanarko Sony Wibisono , Utomo Budi 
Published: January 2025

Background: Diabetic peripheral neuropathy (DPN) is a significant contributor to the development of foot ulcers and limb loss by increase in peak plantar pressure (PPP). Proprioceptive neuromuscular facilitation (PNF) techniques has a good impact on PPP has been investigated before. The objective of this study was to elucidate the importance of decreasing PPP in type 2 diabetes mellitus patients with diabetic neuropathy. This was achieved by investigating the immediate impact of PNF stretching of the calf muscles on peak plantar pressure during gait.
Methods: This was a pre-experimental study with one group pretest-posttest without a control group with a quasi-experimental study design at Dr. Soetomo Hospital Surabaya from February to November 2023. The intervention began with the examiner passively stretching the subject calf muscle until they experienced slight discomfort, maintaining the stretch for 10 seconds. When this position was attained, the subject was instructed to engage in an isometric contraction of the calf muscle against the physician's resistance, exerting a maximal voluntary contraction (MVC) of 50-60% for 6 seconds. Then, the subject was taught to relax the calf musculature completely. Afterward, the physician proceeded to stretch the calf muscle back to the newly acquired joint ROM for 10 seconds. Following a one-minute rest, this PNF stretching method was repeated for 3 sets and carried out on both legs.
Results: The mean value of PPP was significantly decreased at the midfoot, big toe, and toe area (p<0.05). There is also a significant reduction in the total peak plantar pressure value obtained after given PNF stretching of calf muscle (p<0.05). Whereas in the hindfoot and forefoot areas, after being given a PNF stretching intervention there was an increase in the mean value of PPP (p>0.05).
Conclusion: The immediate effect of PNF stretching of the calf muscle significantly reduces peak plantar pressure values in the total peak pressure, midfoot, big toe, and toe areas among type 2 diabetes mellitus patients with diabetic neuropathy
Predictors of depression among patients with cervical cancer in Bali Indonesia
Authors: Aryani Putu , Mahendra I Nyoman Bayu , Djelantik Anak Agung Ayu Manik Jantine , Lesmana Cokorda Bagus Jaya , Wirawan I Made Ady , Suastika Ketut , Januraga Pande Putu 
Published: January 2025

Introduction: Mental distress has been highlighted as one of the biggest concerns, particularly for people with chronic diseases, such as cervical cancer. To date, it is unknown what the prevalence and predictors of depression in patients with cervical cancer are in Bali, Indonesia. This study assessed the proportion of depression and its predictors among patients with cervical cancer who were treated at the largest referral hospital, Prof. dr. I.G.N.G Ngoerah Hospital, in Bali, Indonesia.
Methods: This is a cross-sectional analytic study, which was conducted from March to December 2018 at the Gynecology Policlinic of Prof. dr. I.G.N.G Ngoerah Hospital Bali. A consecutive sampling technique was applied to select 121 patients with cervical cancer at the center. All patients who agreed to participate were interviewed to collect data on sociodemographic and clinical characteristics. They were then screened for the presence of depression symptoms using the Hospital-based Anxiety and Depression Scale (HADS) questionnaire which has been translated into Bahasa Indonesia. Based on the scale, depression was categorized into depression, borderline case, and normal. Predictors of depression were identified using a chi-square test followed by logistic regression using SPSS 2.0.
Results: This study found that 24% of the respondents had probable depression and 9% had depression. This is significantly higher than the depression rate in the general population. Factors that were significantly associated with probable depression and depression were lower education levels (p=0.017). Other variables: age, occupation, marital status, level of knowledge toward cervical cancer, type of therapy, and co-existing disease were not significantly associated with depression among cervical cancer patients.
Conclusions: Depression and probable depression were quite prevalent among patients with cervical cancer. Mental health care responses targeting patients with cervical cancer, particularly those with low education levels should therefore be prioritized, especially during their intensive chemotherapy or radiotherapy.