bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Regeneration After Sinus Floor Elevation in an Intact Sinus or a Sinus With Prior Large Membrane Perforation: A Preclinical Study Using a Rabbit Sinus Model
Authors: Lee Sunmin , Chung Jong‐Hyuk , Thoma Daniel S. , Jung Ronald E. , Jung Ui‐Won , Shin Seung‐Yun , Lim Hyun‐Chang 
Published: December 2024

ABSTRACTAimTo determine bone regeneration following sinus floor elevation (SFE) at sites with or without prior sinus membrane perforation.Materials and MethodsThe sinus membranes in the maxillary sinuses of 12 rabbits were intentionally perforated (≥ 5 mm) on one side, followed by application of a collagen matrix. SFE was performed on both sinuses after 8 weeks of healing, presenting two groups: SFE with a previous large sinus membrane perforation (group SFE_Perf), and in an intact sinus (group SFE). The animals were euthanized at 2 and 4 weeks after SFE. Micro‐computed tomographic and histomorphometric analyses were performed.ResultsThe amount of newly formed bone within the augmented area did not differ significantly between the two groups at 2 weeks and 4 weeks (4.7 ± 1.0 mm2 vs. 5.3 ± 1.4 mm2 and 9.2 ± 1.7 mm2 vs. 10.8 ± 2.2 mm2, respectively, mean ± SD; p > 0.05). However, the amount of newly formed bone near the middle of the sinus membranes was significantly greater in group SFE than in group SFE_Perf (p < 0.05). There was no significant difference in the augmented volume. Fewer subepithelial glands and denser collagen fibres within the sinus membranes were observed in group SFE_Perf than in group SFE.ConclusionsA large perforation of the sinus membrane followed by an 8‐week healing period did not jeopardize new bone formation following SFE.
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Authors: Tavelli Lorenzo , Kripfgans Oliver D. , Chan Hsun‐Liang , Vera Rodriguez Maria , Sabri Hamoun , Mancini Leonardo , Wang Hom‐Lay , Giannobile William V. , Barootchi Shayan 
Published: December 2024

The cover image is based on the article Doppler ultrasonographic evaluation of tissue revascularization following connective tissue graft at implant sites by Lorenzo Tavelli etal., https://doi.org/10.1111/jcpe.13889.
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A systematic review and meta‐analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low‐risk women
Authors: Maged Ahmed M. , El‐Goly Nour A. , Turki Doaa , Bassiouny Nehal , El‐Demiry Nihal 
Published: December 2024

AbstractObjectivesTo evaluate the efficacy and safety of Carbetocin compared to oxytocin in prevention of postpartum hemorrhage (PPH) after low‐risk cesarean delivery (CD).Search StrategyScreening of Medline, Web Of Science, Scopus, Google scholar, and clinical trials registry till January 2024 using the key words related to carbetocin, blood loss, PPH, Cesarean section and their MeSH terms was done.Selection CriteriaThis study included all RCTs conducted on women with low risk for developing PPH after CD and compared the administration of carbetocin to oxytocin without any language limitation. These studies compared carbetocin to oxytocin alone or oxytocin combined with misoprostol. The review included all doses and routes of carbetocin and oxytocin administration.Data Collection and AnalysisThe extracted data included study settings, the participants' size and characteristics, intervention details of both the study and control groups especially data about the dose route and timing of drug administration, the outcome parameters and trial registration details The reported outcomes included the requirement of additional uterotonic agents or blood transfusion, the difference between preoperative and postoperative hemoglobin, the occurrence of PPH, blood loss and drug adverse effects.Main ResultsSeventeen studies including 3667 participants were included. The need for additional uterotonic agents was evaluated in 14 studies with 3154 participants and revealed an OR of 0.53 with 95% CI of 0.39 and 0.72 (p < 0.001, I2 41%). The incidence of PPH was reported in 11 studies with 2228 participants and revealed an Odd ratio of 1.08 with 95%CI of [0.81, 1.44] (p = 0.61, I2 0%). The hemoglobin drop after the operation was evaluated in 3 studies with 1240 participants and revealed an MD of −0.08 with 95% CI of −0.10 and − 0.06 (p < 0.001, I2 0%). The need for blood transfusion was evaluated in 9 studies with 1936 participants and revealed an OR of 0.57 with 95% CI of 0.34 and 0.97 (p = 0.04, I2 0%).ConclusionCarbetocin administration during CD in women with low risk for PPH is associated with less need for additional uterotonic agents (moderate evidence), less need for blood transfusion (high evidence) and lower hemoglobin drop (high evidence) when compared to those who underwent oxytocin administration without an increase in adverse effects.
Effect of an intensive lifestyle intervention on cystatin C–based kidney function in adults with overweight and obesity: From the PREDIMED‐Plus trial
Authors: Martínez‐Montoro José Ignacio , Cornejo‐Pareja Isabel , Díaz‐López Andrés , Sureda Antoni , Toledo Estefania , Abete Itziar , Babio Nancy , Tur Josep A. , Martinez‐Gonzalez Miguel A. , Martínez J. Alfredo , Fitó Montse , Salas‐Salvadó Jordi , Tinahones Francisco J. ,   PREDIMED‐Plus Investigators
Published: December 2024

AbstractBackgroundLarge‐scale trials evaluating a multicomponent lifestyle intervention aimed at weight loss on kidney function are lacking.MethodsThis was a post hoc analysis of the “PREvención con DIeta MEDiterránea‐Plus” (PREDIMED‐Plus) randomized controlled trial, including patients with overweight/obesity and metabolic syndrome, measured cystatin C and creatinine. Participants were randomly assigned (1:1) to an intensive weight loss lifestyle intervention (intervention group [IG]) consisting of an energy‐restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support, or a control group (CG) receiving ad libitum MedDiet recommendations. The primary outcome was between‐group differences in cystatin C–based kidney function (cystatin C–based estimated glomerular filtration rate—eGFRcys—and combined cystatin C–creatinine‐based eGFR—eGFRcr‐cys) change from baseline to 12 and 36 months. Secondary outcomes included between‐group differences in creatinine‐based eGFR (eGFRcr) and urinary albumin‐to‐creatinine ratio (UACR) change and the predictive capacity of these formulas at baseline for new‐onset chronic kidney disease (CKD).ResultsA total of 1909 participants (65 ± 5 years, 54% men) were included. Twelve‐month decline in eGFRcys, eGFRcr‐cys, and eGFRcr was greater in the CG compared to the IG, with between‐group differences of −1.77 mL/min/1.73 m2 [95% confidence interval −2.92 to −0.63], −1.37 [−2.22 to −0.53], and −0.91 [−1.74 to −0.71], respectively. At 36 months, the decline in eGFRcr‐cys and eGFRcr was greater in the CG. No between‐group differences in UACR were found. Significant adjusted areas under the curve for baseline eGFRcys and eGFRcr‐cys were observed for incident CKD at 36 months, which were similar to those for eGFRcr and UACR.ConclusionsIn older adults with overweight/obesity and metabolic syndrome, the PREDIMED‐Plus intervention may be an optimal approach to preserve kidney function.
Description of School Outcomes Among Children With Traumatic Brain Injuries, Centers for Disease Control and Prevention's National Concussion Surveillance System Pilot
Authors: Waltzman Dana , Peterson Alexis B. , Chang Daniel , Daugherty Jill 
Published: December 2024

ABSTRACTBackgroundTraumatic brain injury (TBI) is a common injury in children. Though research on youth TBI has largely focused on high school students, this study describes selected school outcomes after TBI in the past 12 months among children aged 5–17 years.MethodsData from parent‐proxy respondents from the pilot administration of the National Concussion Surveillance System (a random‐digit‐dial telephone survey with over 10,000 adult respondents) were examined. Descriptive statistics of demographic and injury characteristics of children who sustained a TBI were calculated. The association between TBI signs/symptoms and selected school outcomes were determined by multinomial logistic regressions.ResultsAmong the 3557 children sampled via parent‐proxy‐reporting, 9.9% sustained a TBI in the past year. Changes in sleep or being more tired than usual, trouble concentrating, sensitivity to light or noise, and difficulty learning or remembering new things were associated with a greater risk of worse school outcomes following a TBI.Implications for School Health Policy, Practice, and EquityTo promote a positive return to learn (RTL) experience among children following TBI, school districts may prioritize accommodations (e.g., breaks in learning, extra time for assignments) and implement existing ascending levels of academic support where warranted.ConclusionThese findings may inform stakeholders seeking to enhance RTL and provide needed support or services for school‐aged children who sustain a TBI.
Ambulatory care utilization in the first 24 months’ postpartum by rurality and pregnancy‐related conditions: A prospective cohort study from Maine
Authors: Bebus Sydney M. , Palmsten Kristin , Lipkind Heather S. , Ackerman‐Banks Christina M. , Ahrens Katherine A. 
Published: December 2024

AbstractPurposeTo estimate the rate of ambulatory care use among postpartum persons by rurality of residence and pregnancy‐related conditions.MethodsWe used Maine Health Data Organization's All Payer Claims Data for persons who delivered between 2007 and 2019 (N = 121,905). We estimated rates of ambulatory care (nonemergency department outpatient health care) utilization during the first 24 months’ postpartum by level of rurality (urban, large rural, small rural, and isolated rural) and by pregnancy‐related conditions (prenatal depression, hypertensive disorders of pregnancy, and gestational diabetes). To estimate rate ratios (RR), we used Poisson regression with an offset for population at risk, adjusting for potential confounders and restricting the analysis to those with continuous insurance (n = 70,431).FindingsThe mean monthly rate per 100 deliveries of ambulatory care visits was 86.1; the median number of visits was 12 (interquartile range = 6, 25). Persons living in rural areas had lower monthly rates of visits than persons living in urban areas (adjusted RR ranged from 0.87 [95% CI: 0.85, 0.89] in isolated rural areas to 0.91 [95% CI: 0.90, 0.93] in large rural areas). Persons with prenatal depression (aRR = 2.07; 95% CI: 2.04, 2.11), hypertensive disorders of pregnancy (aRR = 1.07; 95% CI: 1.05, 1.10), and gestational diabetes (aRR = 1.11; 95% CI: 1.08, 1.14) had higher rates of visits than those without these conditions.ConclusionsNew practices and policies may be needed to improve postpartum ambulatory care access and utilization in rural areas. Postpartum persons with pregnancy‐related conditions are accessing ambulatory care at higher rates after delivery, which may reduce their need for acute health care use.
Autolyzed brewer's yeast enhances growth and intestinal health in early life stages of Nile tilapia (Oreochromis niloticus L.)
Authors: Odu‐Onikosi Sheu G. , Momoh Taofik A. , Eynon Benjamin , Pontefract Nicola , Kuri Victor , Kühlwein Holger , Merrifield Daniel L. 
Published: December 2024

AbstractThe early life stages of fish are critical for determining the overall productivity and sustainability of aquaculture operations. This study investigated the effects of dietary autolyzed brewer's yeast (ABY) on the growth performance and intestinal health of Nile tilapia fry (Oreochromis niloticus). A 35‐day feeding trial with 480 Nile tilapia fry across 12 experimental tanks tested the effects of diets supplemented with 1, 2, and 4 g/kg of ABY, with a control diet for comparison. The results indicated that the diet which had 1 g/kg ABY supplementation (ABY1) significantly enhanced the weight gain and specific growth rate (SGR) while reducing feed conversion ratio (FCR) compared to the control diet. Intestinal gene expression analysis showed significant upregulation of immunoregulatory genes (tlr2, il10, il1β, and igm), and a tight junction gene (occludin) in the ABY1 group. Conversely, tnfα expression was significantly downregulated in the ABY1 and ABY2 groups, indicating a potential anti‐inflammatory effect. Histological analysis of the mid‐intestine revealed healthy morphology with no significant differences in mucosal fold length, muscularis thickness, lamina propria width, and goblet cell count among the treatment groups. The findings demonstrate that supplementing diets with ABY at 1 g/kg level enhances growth performance and modulates the intestinal immune response of Nile tilapia fry, without compromising intestinal integrity. This study offers valuable insights into using ABY as a functional feed additive to enhance Nile tilapia health and development, as well as to promote aquaculture sustainability.
Macroevolutionary inference of complex modes of chromosomal speciation in a cosmopolitan plant lineage
Authors: Tribble Carrie M. , Márquez‐Corro José Ignacio , May Michael R. , Hipp Andrew L. , Escudero Marcial , Zenil‐Ferguson Rosana 
Published: December 2024

Summary
The effects of single chromosome number change—dysploidy – mediating diversification remain poorly understood. Dysploidy modifies recombination rates, linkage, or reproductive isolation, especially for one‐fifth of all eukaryote lineages with holocentric chromosomes. Dysploidy effects on diversification have not been estimated because modeling chromosome numbers linked to diversification with heterogeneity along phylogenies is quantitatively challenging.
We propose a new state‐dependent diversification model of chromosome evolution that links diversification rates to dysploidy rates considering heterogeneity and differentiates between anagenetic and cladogenetic changes. We apply this model to Carex (Cyperaceae), a cosmopolitan flowering plant clade with holocentric chromosomes.
We recover two distinct modes of chromosomal evolution and speciation in Carex. In one diversification mode, dysploidy occurs frequently and drives faster diversification rates. In the other mode, dysploidy is rare, and diversification is driven by hidden, unmeasured factors. When we use a model that excludes hidden states, we mistakenly infer a strong, uniformly positive effect of dysploidy on diversification, showing that standard models may lead to confident but incorrect conclusions about diversification.
This study demonstrates that dysploidy can have a significant role in speciation in a large plant clade despite the presence of other unmeasured factors that simultaneously affect diversification.
Deciphering the Vulnerability of Pollen to Heat Stress for Securing Crop Yields in a Warming Climate
Authors: Lohani Neeta , Singh Mohan B. , Bhalla Prem L. 
Published: December 2024

ABSTRACTClimate change is leading to more frequent and severe extreme temperature events, negatively impacting agricultural productivity and threatening global food security. Plant reproduction, the process fundamental to crop yield, is highly susceptible to heatwaves, which disrupt pollen development and ultimately affect seed‐set and crop yields. Recent research has increasingly focused on understanding how pollen grains from various crops react to heat stress at the molecular and cellular levels. This surge in interest over the last decade has been driven by advances in genomic technologies, such as single‐cell RNA sequencing, which holds significant potential for revealing the underlying regulatory reprogramming triggered by heat stress throughout the various stages of pollen development. This review focuses on how heat stress affects gene regulatory networks, including the heat stress response, the unfolded protein response, and autophagy, and discusses the impact of these changes on various stages of pollen development. It highlights the potential of pollen selection as a key strategy for improving heat tolerance in crops by leveraging the genetic variability among pollen grains. Additionally, genome‐wide association studies and population screenings have shed light on the genetic underpinnings of traits in major crops that respond to high temperatures during male reproductive stages. Gene‐editing tools like CRISPR/Cas systems could facilitate precise genetic modifications to boost pollen heat resilience. The information covered in this review is valuable for selecting traits and employing molecular genetic approaches to develop heat‐tolerant genotypes.
Short‐Term High Light Stress Analysis Through Differential Methylation Identifies Root Architecture and Cell Size Responses
Authors: Nair Akshay U. , Kundariya Hardik S. , Samantaray Devidutta , Dopp Isaac J. , Allu Annapurna Devi , Mackenzie Sally A. 
Published: December 2024

ABSTRACTDNA methylation repatterning is an epigenomic component of plant stress response, but the extent that methylome data can elucidate changes in plant growth following stress onset is not known. We applied high‐resolution DNA methylation analysis to decode plant responses to short‐ and long‐term high light stress and, integrating with gene expression data, attempted to predict components of plant growth response. We identified 105 differentially methylated genes (DMGs) following 1 h of high light treatment and 193 DMGs following 1 week of intermittent high light treatment. Two distinct methylome‐predicted plant growth responses to high light treatment could be confirmed by linking methylome changes in auxin response pathways to observed changes in root architecture and methylome changes in cell cycle pathway components to endoreduplication and palisade cell enlargement. We observed methylome changes in a cyclic GMP‐dependent protein kinase in association with high light stress signalling. The ability to associate intragenic methylation repatterning with predictable plant phenotypic outcomes after a limited period of high light treatment allows for data‐based early prediction of plant growth responses. The approach also permits the dissection of gene networks underpinning plant growth adjustments during environmental change to uncover dynamic phenotype determinants.
Description of four new species of Mychonastes (Chlorophyceae) from Japanese freshwater habitats based on molecular and morphological data
Authors: Nozaki Hisayoshi , Matsuzaki Ryo , Mori Fumi , Sato Mayumi , Yamaguchi Haruyo , Higashiyama Tetsuya , Kawachi Masanobu , Tanabe Yuuhiko 
Published: December 2024

SUMMARYSpecies of the green algal genus Mychonastes have been recognized as ubiquitous ultrasmall components of freshwater communities worldwide, mainly based on molecular data. However, detailed taxonomic identification of Japanese members of Mychonastes has not yet been conducted. We taxonomically identified species of 13 Mychonastes strains in the Microbial Culture Collection at the National Institute for Environmental Studies originating from Japan based on molecular data and comparative morphology. The strains were classified into 10 species, including four new species, Mychonastes ariiae Nozaki sp. nov. (NIES‐2900), Mychonastes takamurae Nozaki sp. nov. (NIES‐2334, 2336), Mychonastes kasaiae Nozaki sp. nov. (NIES‐3743) and Mychonastes gigas Nozaki sp. nov. (NIES‐2340). Ultrastructural features of the cell walls and chloroplasts of these four species were consistent with the generic concept of Mychonastes. The four new species are distinguishable from other species of Mychonastes based on differences in nuclear ribosomal DNA (rDNA) internal transcribed spacer (ITS) sequences and morphological features including the mucilaginous matrix surrounding the cells, mode of rupture of the mother cell wall during daughter cell release, formation of large colonies in liquid culture and colony morphology on agar plates. The evolution of Mychonastes species is discussed based on phylogenetic inferences obtained using a combined dataset for four chloroplast genes (psaB, rbcL, psbC and atpB) and rDNA ITS sequences.
Role of Globalization and Innovation Pattern in Growth of Bank Credit: Evidence From Emerging and Advanced Asia
Authors: Pal Shreya , Mahalik Mantu Kumar 
Published: December 2024

ABSTRACTThis study examines the role of globalization and innovation pattern (i.e., innovation by the residents and non‐residents) in the growth of domestic bank credit across emerging and advanced Asian economies spanning from 1996 to 2022. The bank credit growth model includes economic growth and real interest rate as important control variables. This study employs Cross Sectional‐Autoregressive Distributed Lag (CS‐ARDL) as an appropriate baseline method because of the cointegration, endogeneity, and cross‐sectional dependency present in the data. The long‐run results for emerging Asian economies indicate that globalization exhibits a negative impact on banking credit, contrasting with the positive influence observed in advanced Asian economies due to heightened economic growth and increased credit demand. Residential innovation consistently bolsters banking credit in both sets of economies, albeit with mixed effects stemming from non‐resident innovation. The long‐run results further indicate the positive (negative) impact of economic growth (real interest rate) on bank credit in emerging and advanced Asian economies. These findings are reliable due to the similar results obtained from using Driscoll‐Kraay Robust Standard Errors (DKSEs) as robust method. For policymakers in emerging economies, the imperative policy lies in striking a delicate balance between economic openness and bank credit, while counterparts in advanced economies are poised to bolster bank credit accessibility through foreign innovation while upholding stringent regulatory oversight.