bluuebunny/crossref_metadata_2025_split huggingface dataset:
Botanical biopesticide combination concept—a viable option for pest management in organic farming
Authors: Reddy D. Srinivas , Chowdary N. Mounica 
Published: January 2021

AbstractBackgroundEntomopathogens are frequent natural enemies of arthropods worldwide, and they are capable of alternative control agents against the important pests. The optimally selected botanical product can minimize their harmful effect on these entomopathogens, and it becomes essential to know the influence of combinations of botanicals and biopesticides (botanical biopesticide combination (BBC)) in comparison to their sole action.Main bodyBotanicals, especially neem products, are highly efficient to be combined with the entomopathogens (with some exceptions). There are many possible reasons for the synergistic action of these botanicals, attacking the immune system of the insect being one of the important ones. These botanicals when applied in combination with microbial pesticides showed maximum sublethal effects rather than complete mortality, making them the best alternatives for combating resistance development in insects. To work effectively, biological control agents must be used within a compatible program combined with botanicals. It is highly difficult for such products to compete with chemical controls in high-value crops, so where they can become a commercially viable option in organic cultivation. The increasing acreage is under organic production for high-value export crops, where pesticide residues are undesirable for the environment, and biopesticides and botanicals are good choices for crop protection. Concerning the effect of these products used in pest control, a significant reduction in dosage in relation to the individuals is noticed.ConclusionBy combining the performance and safety, biopesticides and botanicals are efficacious. This knowledge should facilitate the choice of biopesticides compatible with less harmful or naturally occurring botanicals. And if these have to be incorporated into a pest management program through an organic approach, it is necessary to determine the effects of botanicals on the beneficial microbes, on the behavior of pest, the importance of application technique, and the role of application timing for these botanical biopesticide combinations.
Female and male-controlled livestock holdings impact pastoralist food security and women’s dietary diversity
Authors: Gitungwa H. , Gustafson C. R. , Jimenez E. Y. , Peterson E. W. , Mwanzalila M. , Makweta A. , Komba E. , Kazwala R. R. , Mazet J. A. K. , VanWormer E. 
Published: January 2021

Abstract
Background
Food insecurity is a global problem that requires a One Health approach. As many households in low- and middle-income nations rely on crops and livestock that they produce to meet their household’s needs, food security and nutrition are closely linked to the health of animals and the environment. Resources controlled by women are more often allocated to uses that benefit the entire household, such as food, health, and educating children, than men’s resources. However, studies of gender control of resources among pastoralist societies are scant. We examined the effect of female and male control of livestock resources on food security and women’s dietary diversity among households from one agro-pastoralist and two pastoralist tribes in Iringa Region in south-central Tanzania.

Methods
We conducted surveys with 196 households, which included questions on food availability and food consumption among women, livestock holdings, gender control of livestock and livestock product income, and household demographics, as well as open-ended questions on the use of income. Food availability and food consumption responses were used to construct food security and women’s dietary diversity indexes, respectively. We conducted mixed effects logistic regression to analyze how household food security and dietary diversity were associated with livestock and other household variables. We also examined qualitative responses for use of income controlled by women and how the household obtained income when needed.

Results
Female-controlled livestock generally supported better household nutrition outcomes. Greater chicken holdings increased the probability of being food secure in pastoralist households but decreased it in agro-pastoralist households, while increasing the probability of having medium-high dietary diversity among all tribes. Male-controlled livestock holdings were not related to food security status. Women used income to supplement food supplies and livestock they controlled as a primary response to unanticipated household needs.

Conclusions
Our results show that female-control of livestock is significantly related to household food security and dietary diversity in pastoralists and agro-pastoralists in rural Tanzania. Importantly, the relationship between food security and dietary diversity differs among tribes for both male and female-controlled livestock, which suggests that blanket policies regarding management of livestock holdings may have unintended consequences.
Host reproductive cycle influences the pouch microbiota of wild southern hairy-nosed wombats (Lasiorhinus latifrons)
Authors: Weiss Sesilje , Taggart David , Smith Ian , Helgen Kristofer M. , Eisenhofer Raphael 
Published: January 2021

Abstract
Background
Marsupials are born much earlier than placental mammals, with most crawling from the birth canal to the protective marsupium (pouch) to further their development. However, little is known about the microbiology of the pouch and how it changes throughout a marsupial’s reproductive cycle. Here, using stringent controls, we characterized the microbial composition of multiple body sites from 26 wild Southern Hairy-nosed Wombats (SHNWs), including pouch samples from animals at different reproductive stages.

Results
Using qPCR of the 16S rRNA gene we detected a microbial community in the SHNW pouch. We observed significant differences in microbial composition and diversity between the body sites tested, as well as between pouch samples from different reproductive stages. The pouches of reproductively active females had drastically lower microbial diversity (mean ASV richness 19 ± 8) compared to reproductively inactive females (mean ASV richness 941 ± 393) and were dominated by gram positive bacteria from the Actinobacteriota phylum (81.7–90.6%), with the dominant families classified as Brevibacteriaceae, Corynebacteriaceae, Microbacteriaceae, and Dietziaceae. Three of the five most abundant sequences identified in reproductively active pouches had closest matches to microbes previously isolated from tammar wallaby pouches.

Conclusions
This study represents the first contamination-controlled investigation into the marsupial pouch microbiota, and sets a rigorous framework for future pouch microbiota studies. Our results indicate that SHNW pouches contain communities of microorganisms that are substantially altered by the host reproductive cycle. We recommend further investigation into the roles that pouch microorganisms may play in marsupial reproductive health and joey survival.
Bacteremia as a risk factor for variceal upper gastrointestinal tract bleeding in cirrhotic patients: a hospital-based study
Authors: Zidan Mohamad Husseini Saeid , Zaghloul Sahar Gouda , Seleem Waseem Mohamed , Ahmed Hanan Samir , Gad Ahmed Ibrahim 
Published: January 2021

Abstract
Background
The presence of bacteremia as a complication of variceal bleeding in patients with liver cirrhosis had been investigated by many studies. The aim of this study was to assess the bacteremia as a risk factor for variceal upper gastrointestinal tract bleeding in cirrhotic patients. A cross-sectional study was conducted on 99 patients with chronic liver disease divided into three groups: group I included 35 patients presented with first attack of variceal bleeding, group II included 35 patients presented with recurrent attacks of variceal bleeding, and group III included 29 patients with no history of previous variceal bleeding as a control group. Routine laboratory tests were done, upper GI endoscopy, blood culture, and measurement of procalcitonin level in blood.

Results
Patients with recurrent variceal bleeding had statistically (p < 0.05) the highest percentage of positive blood culture followed by patients with first variceal bleeding and the control (60% vs 45.7% vs 24.1%) respectively. In addition to procalcitonin results, patients with recurrent variceal bleeding had statistically the highest values of PCT followed by patients with first variceal bleeding and the control (1.92 vs 0.325 vs 0.22 ng/ml) respectively. Multivariate regression analysis showed that procalcitonin and hemoglobin only was the significant predictors for variceal bleeding. Hemoglobin at cutoff value of ≤ 9.6 and procalcitonin (ng/dl) at cutoff value of > 1.76 is the most specific in predicting bleeding 86.21%, 86.21% (CI 95%) respectively.

Conclusion
Bacteremia and procalcitonin are risk factor for variceal bleeding in cirrhotic patients. Procalcitonin can be used as easily measurable and surrogate biomarker for bacteremia and variceal bleeding.
Screening of polysaccharides from fruit pulp of Ziziphus mauritiana L. and Artocarpus heterophyllus L. as natural mucoadhesives
Authors: Ray Priyanka , Chatterjee Sumana , Saha Prerona 
Published: January 2021

Abstract
Background
Mucoadhesive polymers are applicable for improving the delivery of drug by prolonging the residence time and time of contact of the dosage form with the mucous membrane. Mucoadhesion may be defined as a process where the polymer substance gets adhered either to the biological substrate or synthetic or to a natural macromolecule, or to the mucus membrane. The natural polymers can be studied to determine whether they possess some mucoadhesive properties as several excipients derived from plants have proved their potential in the field of conventional or novel dosage form. The present work aims at determination of physical properties of polysaccharides from fruit pulp of Ziziphus mauritiana L. (ZM gum) and Artocarpus heterophyllus L. (AH gum), such as mucoadhesive strength (shear stress determination), swelling index, pH, viscosity, angle of repose, Carr’s index, density, and its comparative study with synthetic polymers Carbopol 934 and HPMC and also to study its FTIR and 1H-NMR spectra analysis.

Result
The most important properties such as mucoadhesive strength of ZM gum (3% w/v) and AH gum (3%) was found to be comparable with HPMC (3% w/v) and Carbopol 934 (3% w/v); also, the swelling index of the isolated gums were also found comparable with both HPMC and Carbopol 934. Falling sphere method is conducted in which the time taken by the sphere to move 50 divisions to the bottom for 3% w/v ZM gum solution was 10.14 s and for AH gum was 10.13 s which is comparable to HPMC and Carbopol 934. The FTIR & 1H NMR spectra showed typical characteristic signals of polysaccharides and presence of typical sugar residues.

Conclusion
From the study, it can be concluded that ZM and AH gum has potential to be better than Carbopol 934 and HPMC in respect of mucoadhesive strength and also it has the potential to replace some synthetic mucoadhesive polymers and polysaccharides.
Assessment of gas hydrate using prestack seismic inversion in the Mahanadi Basin, offshore eastern India
Authors: Ojha Maheswar , Ghosh Ranjana 
Published: January 2021

The Indian National Gas Hydrate Program Expedition-01 in 2006 has discovered gas hydrate in the Mahanadi offshore basin along the eastern Indian margin. However, well-log analysis, pressure core measurements, and infrared anomalies reveal that gas hydrates are distributed as disseminated within the fine-grained sediment, unlike massive gas hydrate deposits in the Krishna-Godavari Basin. The 2D multichannel seismic section, which crosses holes NGHP-01-9A and 19B located at approximately 24 km apart, indicates a continuous bottom-simulating reflector (BSR) along it. We aim to investigate the prospect of gas hydrate accumulation in this area by integrating well-log analysis and seismic methods with rock-physics modeling. First, we estimate gas hydrate saturation at these two holes from the observed impedance using the three-phase Biot-type equation. Then, we establish a linear relationship between the gas hydrate saturation and the impedance contrast with respect to the water-saturated sediment. Using this established relation and impedance obtained from prestack inversion of seismic data, we produce a 2D gas hydrate-distribution image over the entire seismic section. The gas hydrate saturation estimated from resistivity and sonic data at well locations varies within 0%–15%, which agrees well with the available pressure core measurements at hole 19. However, the 2D map of gas hydrate distribution obtained from our method indicates that the maximum gas hydrate saturation is approximately 40% just above the BSR between the common-depth points of 1450 and 2850. The presence of gas-charged sediments below the BSR is one of the reasons for the strong BSR observed in the seismic section, which is depicted as low impedance in the inverted impedance section. Closed sedimentary structures above the BSR are probably obstructing the movements of free-gas upslope, for which we do not see the presence of gas hydrate throughout the seismic section above the BSR.
Feasibility of Fine-Needle Aspiration Biopsy and Rapid On-Site Evaluation for Immediate Triage in Breast Cancer Screening in Tanzania
Authors: Philipo Godfrey S. , Vuhahula Edda , Kimambo Asteria , Mmbaga Elia J. , Van Loon Katherine , Ng Dianna L. 
Published: January 2021

PURPOSE Clinical breast examination (CBE) is one of the most common methods used for early detection of breast cancer in low- and middle-income countries. CBE alone is limited by lack of specificity and may result in unnecessary diagnostic procedures. We evaluated the feasibility of integrating CBE, fine-needle aspiration biopsy (FNAB), and rapid on-site evaluation (ROSE) in triaging palpable breast masses for specialized cancer care. MATERIALS AND METHODS An intensive breast cancer screening event was conducted at a national trade fair by a multidisciplinary team of care providers targeting a healthy population in Dar es Salaam, Tanzania. All adults age ≥ 18 years were invited to participate. CBE was performed by oncologists and/or pathologists. FNAB was performed by a pathologist on palpable masses that were then categorized as benign, indeterminate, or suspicious for malignancy or definitively malignant based on ROSE. RESULTS A total of 208 individuals (207 females, one male; median age, 36 years; range, 18-68 years) were screened. Most (90.8%, 189 of 208) had normal findings, whereas 7.2% (15 of 208), 1% (2 of 208), and 1% (2 of 208) had a palpable mass, breast pain, and nipple discharge, respectively. Two participants had lesions too small for palpation-guided biopsy and clinically consistent with fibroadenomas; the participants were counseled, and observation was recommended. FNAB was performed on 13 breast masses, with 9 of 13 (69%) categorized as benign and 4 of 13 (31%) suspicious for malignancy. Final cytopathologic review of referred patients confirmed one case to be breast adenocarcinoma, one was suggestive of fibroadenoma, and two showed inflammations. CONCLUSION Integration of CBE with ROSE and FNAB was feasible in a breast cancer screening program in Tanzania. In settings with constrained resources for cancer care, this may be an effective method for triaging patients with breast masses.
Readiness of Healthcare Systems to Generate Real-World Evidence: Reliability of CT Radiographic End Points for Evaluation of First-Line Systemic Treatment
Authors: Ho Cheryl , Chan Brandon , Cameron David , Shokoohi Aria , Regier Dean A. , Lim Howard 
Published: January 2021

PURPOSE: Regulatory agencies such as the US Food and Drug Administration and health technology assessment bodies are increasingly using real-world evidence (RWE). The ability of healthcare systems to reliably generate response rate and progression-free survival from real-world data is unknown. We examined the capacity of a single-payer system to provide RWE by evaluating the frequency of computed tomography (CT) imaging during standard first-line metastatic systemic treatment of breast, colorectal, and lung cancer. METHODS: A 1-year cohort of patients with metastatic-at-diagnosis breast, colorectal, and lung cancer treated with first-line systemic therapy (excluding hormone therapy) referred to BC Cancer in 2016 was retrospectively reviewed for first-line treatment and CT imaging. Duration of first-line treatment was calculated from the first to the last dose of therapy. CT imaging was counted from the start of therapy to 8 weeks after the last therapy dose. RESULTS: A cohort of 664 patients was identified from the BC Cancer Registry. Distribution of metastatic disease at diagnosis was breast (n = 82), colorectal (n = 214), and lung (n = 368) cancer. For breast, colorectal, and lung cancer, there was a baseline CT within 4 weeks of treatment initiation in 59%, 51%, and 48% of patients, with median duration of first-line treatment of 14.6, 25.3, and 11.9 weeks and median CT imaging interval of 9.1, 9.0, and 6.1 weeks. CONCLUSION: In our publicly funded healthcare system, availability of baseline CT imaging was 48% to 59% and the frequency of assessment ranged from 6.1 to 9.1 weeks, subject to patterns of practice and resource availability. Our system was not capable of providing RWE for image-based end points. Alternative end points should be considered to capitalize on the wealth of real-world data.
Experience of a Pituitary Clinic for US Military Veterans With Traumatic Brain Injury
Authors: Lee Jonathan , Anderson Lindsey J , Migula Dorota , Yuen Kevin C J , McPeak Lisa , Garcia Jose M 
Published: January 2021

Abstract

Context
Traumatic brain injury (TBI) is considered the “signature” injury of veterans returning from wartime conflicts in Iraq and Afghanistan. While moderate/severe TBI is associated with pituitary dysfunction, this association has not been well established in the military setting and in mild TBI (mTBI). Screening for pituitary dysfunction resulting from TBI in veteran populations is inconsistent across Veterans Affairs (VA) institutions, and such dysfunction often goes unrecognized and untreated.

Objective
This work aims to report the experience of a pituitary clinic in screening for and diagnosis of pituitary dysfunction.

Methods
A retrospective analysis was conducted in a US tertiary care center of veterans referred to the VA Puget Sound Healthcare System pituitary clinic with a history of TBI at least 12 months prior. Main outcome measures included demographics, medical history, symptom burden, baseline hormonal evaluation, brain imaging, and provocative testing for adrenal insufficiency (AI) and adult-onset growth hormone deficiency (AGHD).

Results
Fatigue, cognitive/memory problems, insomnia, and posttraumatic stress disorder were reported in at least two-thirds of the 58 patients evaluated. Twenty-two (37.9%) were diagnosed with at least one pituitary hormone deficiency, including 13 (22.4%) AI, 12 (20.7%) AGHD, 2 (3.4%) secondary hypogonadism, and 5 (8.6%) hyperprolactinemia diagnoses; there were no cases of thyrotropin deficiency.

Conclusion
A high prevalence of chronic AI and AGHD was observed among veterans with TBI. Prospective, larger studies are needed to confirm these results and determine the effects of hormone replacement on long-term outcomes in this setting.
A Review on the Synthesis and Applications of Nanoporous Carbons for the Removal of Complex Chemical Contaminants
Authors: Singh Gurwinder , Lee Jang Mee , Kothandam Gopalakrishnan , Palanisami Thavamani , Al-Muhtaseb Ala'a H , Karakoti Ajay , Yi Jiabao , Bolan Nanthi , Vinu Ajayan 
Published: January 2021

Abstract
Around 29% of the world population does not have ready access to safe drinking water. Water contamination is a compelling issue, which needs to be addressed on a priority basis using novel technologies. Heavy metals are the dominant inorganic contaminants found in the water, whereas, organic contaminants are composed of several classes and pose a more widespread problem. The occurrence of radionuclides, such as uranium and caesium in groundwater is also raising a serious issue but it is often understudied. Nanoporous carbons are a good choice for removing water contaminants owing to their excellent physico-chemical properties. Their surface properties, which are highly critical for adsorption, vary significantly with the nature of the precursors used for synthesis. Their textural and surface characteristics can be tuned by adjusting the chemical composition of these precursors or the synthesis conditions, including activation or modification. Such materials can also be supported in a porous matrix, designed into desired morphologies and hybridized with other composite materials for enhancing the application efficiency. The review describes how the low-cost nanoporous carbons are outstanding adsorbent for the water remediation and provide an outlook to tap the unlimited opportunities by researching their new properties.
Contingency as Medium in Gertrude Stein
Authors: Savinel Christine 
Published: January 2021

Gertrude Stein questions the event as an external and contingent accident, to be at least subsumed within the continuum of thinking —the untimely flux of interiormeditation and creation. Throughout her prolific production, one of Stein’s majorattempts was to do away with the event in literature, to dispense with it, to play against it. Stein pointedly selected as her topic the contingency of life within historical time, in her several autobiographical texts from The Autobiography of Alice B. Toklas (1932) to Wars I Have Seen (1944). Wars I Have Seen proves to be a singular work which helps us realise the process through which Stein resists historical contingency. As this essay argues, Wars I Have Seen gives us a remarkable vision of Stein trying to resist the pressure of History, and a vision of literature trying to hold at bay the contingency of events.
What Really Happened? Kenneth Goldsmith’s “7+ Deaths and Disasters,” Sophie Calle’s, Take Care of Yourself
Authors: Perloff Marjorie 
Published: January 2021

In Seven American Deaths and Disasters (2013), Kenneth Goldsmith recounted a set of tragic and unanticipated events in recent American history by using transcriptions of radio and TV broadcasts, usually from minor networks. Designed to be an “eighthAmerican disaster,” Goldsmith presented The Body of Michael Brown, a performance based on the St. Louis autopsy report at the “Interrupt 3” conference at Brown University(13 March 2015), eliciting widespread criticism and controversy. Seemingly very different from Goldsmith—Sophie Calle’s projects, for the past few decades, set up particularprocedural processes that raise pressing epistemological questions, especially about the nature of relationships, personal and political. One of her recent projects, Prenez soin de vous (Take Care of Yourself) that was based on her installation for the Venice Biennale in 2007, comprises comments by 107 women on an email that Calle received from her then lover. In this project, Calle uses the “real” words of others to create a montage of possible interpretations of the discourse that confronts us in our daily lives. For Calle, as for Goldsmith, the most troubling gap is that between information and knowledge, while the issue, that a conceptual poetics can take as a premise, is that the body most difficult to getinside of turns out to be one’s own.