bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eastern Europe’s “Transitional Industry”?: Deconstructing the Early Streletskian
Authors: Dinnis R. , Bessudnov A. , Reynolds N. , Devièse T. , Dudin A. , Pate A. , Sablin M. , Sinitsyn A. , Higham T. 
Published: March 2021

AbstractThe Streletskian is central to understanding the onset of the Upper Palaeolithic on the East European Plain. Early Streletskian assemblages are frequently seen as marking the Neanderthal-anatomically modern human (AMH) anthropological transition, as well as the Middle-to-Upper Palaeolithic archaeological transition. The age of key Streletskian assemblages, however, remains unclear, and there are outstanding questions over how they relate to Middle and Early Upper Palaeolithic facies. The three oldest Streletskian layers—Kostenki 1 Layer V, Kostenki 6 and Kostenki 12 Layer III—were excavated by A. N. Rogachev in the mid-20th century. Here, we re-examine these layers in light of problems noted during Rogachev’s campaigns and later excavations. Layer V in the northern part of Kostenki 1 is the most likely assemblage to be unmixed. A new radiocarbon date of 35,100 ± 500 BP (OxA- X-2717-21) for this assemblage agrees with Rogachev’s stratigraphic interpretation and contradicts later claims of a younger age. More ancient radiocarbon dates for Kostenki 1 Layer V are from areas lacking diagnostic Streletskian points. The Kostenki 6 assemblage’s stratigraphic context is extremely poor, but new radiocarbon dates are consistent with Rogachev’s view that the archaeological material was deposited prior to the CI tephra (i.e. >34.3 ka BP). Multiple lines of evidence indicate that Kostenki 12 Layer III contains material of different ages. Despite some uncertainty over the precise relationship between the dated sample and diagnostic lithic material, Kostenki 1 Layer V (North) therefore currently provides the best age estimate for an early Streletskian context. This age is younger than fully Upper Palaeolithic assemblages elsewhere at Kostenki. Other “Streletskian” assemblages and Streletskian points from younger contexts at Kostenki are briefly reviewed, with possible explanations for their chronostratigraphic distribution considered. We caution that the cultural taxon Streletskian should not be applied to assemblages based simply on the presence of bifacially worked artefacts.
Cova de les Malladetes (Valencia, Spain): New Insights About the Early Upper Palaeolithic in the Mediterranean Basin of the Iberian Peninsula
Authors: Villaverde Valentín , Sanchis Alfred , Badal Ernestina , Bel Miguel Ángel , Bergadà M. Mercè , Eixea Aleix , Guillem Pere M. , Martínez-Alfaro Álvaro , Martínez-Valle Rafael , Martínez-Varea Carmen M. , Real Cristina , Steier Peter , Wild Eva M. 
Published: March 2021

AbstractNew excavations carried out at Cova de les Malladetes confirm and improve previous information on the archaeological sequence of this site. A total of 29 new dates allow to specify the chronology of the Aurignacian (levels XIVA–XII) and Gravettian (levels XI–VII). Furthermore, concerning the results obtained during the 1970 excavation, three new levels were identified: level XIVB, which represents a short temporal human occupation hiatus, and levels XV and XVI with some hearths and anthropic evidence, although the lithic material does not permit a cultural attribution. This paper presents data obtained from the analysis of archaeobotanical, micro- and macrofaunal assemblages and lithic and osseous industry. Results are relevant concerning the palaeoclimatic and palaeoenvironmental characterisation of the Early Upper Palaeolithic, as well as for assessing the human occupation patterns during the Gravettian and Aurignacian. Moreover, we evaluate the chronological implications of the basal levels (XIVB, XV and XVI), drawing attention to the absence of an important temporal gap between this phase and the start of the Early Upper Palaeolithic at the site. Finally, our new data extend the information provided by other sites in the Spanish Mediterranean region, allowing a more defined characterisation of the Early Upper Palaeolithic, especially regarding the Evolved Aurignacian chronology and its techno-typological structure, with the presence of Roc-de-Combe subtype Dufour bladelets.
Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages
Authors: Selezneva Anna , Yoshida Minae , Gibb Alasdair , Willis Dean 
Published: March 2021

Abstract
Background
Macrophages are important cells of the innate immune system and contribute to a variety of physiological and pathophysiological responses. Monovalent and divalent ion channels have been studied in macrophage function, and while much research is still required, a role for these channels is beginning to emerge in macrophages. In addition to the plasma membrane, ion channels are also found in intracellular membranes including mitochondrial, lysosomal and nuclear membranes. While studying the function of plasma membrane located large conductance voltage- and calcium-activated potassium channels (BK channels) in a macrophage cell line RAW264.7, we became aware of the expression of these ion channels in other cellular locations.

Methods
Immunofluorescence and Western blot analysis were used to identify the expression of BK channels. To demonstrate a functional role for the nuclear located channel, we investigated the effect of the lipid soluble BK channel inhibitor paxilline on CREB phosphorylation.

Results
Treatment of resting macrophages with paxilline resulted in increased CREB phosphorylation. To confirm a role for nuclear BK channels, these experiments were repeated in isolated nuclei and similar results were found. Ca2+ and calmodulin-dependent kinases (CaMK) have been demonstrated to regulate CREB phosphorylation. Inhibition of CaMKII and CaMKIV resulted in the reversal of paxilline-induced CREB phosphorylation.

Conclusions
These results suggest that nuclear BK channels regulate CREB phosphorylation in macrophages. Nuclear located ion channels may therefore be part of novel signalling pathways in macrophages and should be taken into account when studying the role of ion channels in these and other cells.

Graphic abstract
The role of brain gaseous neurotransmitters in anxiety
Authors: Pałasz Artur , Menezes Itiana Castro , Worthington John J. 
Published: March 2021

AbstractAlthough anxiety is perhaps one of the most significant current medical and social problems, the neurochemical mechanistic background of this common condition remains to be fully understood. Multifunctional regulatory gasotransmitters are novel, atypical inorganic factors of the brain that are involved in the mechanisms of anxiety responses. Nitric oxide (NO) signaling shows ambiguous action in animal models of anxiety, while NO donors exert anxiogenic or anxiolytic effect depending on their chemical structure, dose, treatment schedule and gas release rapidity. The majority of NO synthase inhibitors act as a relatively potent axiolytic agents, while hydrogen sulfide (H2S) and carbon monoxide (CO) delivered experimentally in the form of “slow” or “fast” releasing donors have recently been considered as anxiolytic neurotransmitters. In this comprehensive review we critically summarize the literature regarding the intriguing roles of NO, H2S and CO in the neuromolecular mechanisms of anxiety in the context of their putative, yet promising therapeutic application. A possible mechanism of gasotransmitter action at the level of anxiety-related synaptic transmission is also presented. Brain gasesous neuromediators urgently require further wide ranging studies to clarify their potential value for the current neuropharmacology of anxiety disorders.
Confinement effects for rubberised concrete in tubular steel cross-sections under combined loading
Authors: Mujdeci A. , Bompa D. V. , Elghazouli A. Y. 
Published: March 2021

Abstract
This paper describes an experimental investigation into confinement effects provided by circular tubular sections to rubberised concrete materials under combined loading. The tests include specimens with 0%, 30% and 60% rubber replacement of mineral aggregates by volume. After describing the experimental arrangements and specimen details, the results of bending and eccentric compression tests are presented, together with complementary axial compression tests on stub-column samples. Tests on hollow steel specimens are also included for comparison purposes. Particular focus is given to assessing the confinement effects in the infill concrete as well as their influence on the axial–bending cross-section strength interaction. The results show that whilst the capacity is reduced with the increase in the rubber replacement ratio, an enhanced confinement action is obtained for high rubber content concrete compared with conventional materials. Test measurements by means of digital image correlation techniques show that the confinement in axial compression and the neutral axis position under combined loading depend on the rubber content. Analytical procedures for determining the capacity of rubberised concrete infilled cross-sections are also considered based on the test results as well as those from a collated database and then compared with available recommendations. Rubber content-dependent modification factors are proposed to provide more realistic representations of the axial and flexural cross-section capacities. The test results and observations are used, in conjunction with a number of analytical assessments, to highlight the main parameters influencing the behaviour and to propose simplified expressions for determining the cross-section strength under combined compression and bending.
The Health Risks of Airborne Polycyclic Aromatic Hydrocarbons (PAHs): Upper North Thailand
Authors: Kongpran Jira , Kliengchuay Wissanupong , Niampradit Sarima , Sahanavin Narut , Siriratruengsuk Weerayuth , Tantrakarnapa Kraichat 
Published: March 2021

AbstractEvery year, Northern Thailand faces haze pollution during the haze episode. The particulate matter (PM), including fine fraction (PM2.5), a coarse fraction (PM2.5–10), and 16 polycyclic aromatic hydrocarbons (PAHs), was measured in six provinces in upper north Thailand during the haze and non‐haze episodes in 2018. Eighty‐three percent of the PM2.5 measurements (21.8–194.0 µg/m3) during the haze episode exceeded the national ambient air quality standard in Thailand. All 16 PAHs were detected in the study area in both periods. The average concentration of total PAHs (particle‐bound and gas‐phase) during the haze episode was 134.7 ± 80.4 ng/m3, which was about 26 times higher than those in the non‐haze (5.1 ± 9.7 µg/m3). Naphthalene and acenaphthene were the dominant PAHs in the gas phase; whereas, indeno[123‐cd] pyrene, benzo[a]pyrene, and Benzo[ghi]Perylene were dominant in the particle‐bound phase. The estimated inhalation excess cancer risk from PAHs exposure was 9.3 × 10−4 and 2.5 × 10−5 in the haze episode and non‐haze, respectively. Diagnostic ratios and principal component analysis revealed that PAHs were derived from mixed sources of vehicle emission and solid combustion in the haze episode and vehicle emission in the non‐haze period. High pollution levels of PM and large cancer risk attributable to the exposure of PAHs in the haze episode suggest urgent countermeasures to reduce the source emission, especially from the solid combustion in the area.
Spatiotemporal Analysis of Seismotectonic State of Injection‐Induced Seismicity Clusters in the Western Canada Sedimentary Basin
Authors: Dokht Ramin M. H. , Kao Honn , Babaie Mahani Alireza , Visser Ryan 
Published: March 2021

AbstractThe observations of spatiotemporal distribution of seismicity in western Canada indicate that the occurrence of earthquakes is tied to the hydraulic fracturing operations and disposal of coproduced wastewater. In this study, we investigate the temporal changes in the frequency‐magnitude distributions for multiple clusters of induced events in regions where the level of background seismicity is low. The induced events are clustered into six major groups using density‐based spatial and soft clustering algorithms based on their epicenters. Each cluster is identified by different distributions of earthquake magnitudes and injection scenarios. The linear relationship between the number of induced earthquakes and cumulative injection volume enables us, on a regional scale, to quantitatively characterize the seismotectonic conditions of the clusters using the estimates of the seismogenic indices. The seismogenic index provides a means to estimate the occurrence probability of earthquakes with a given magnitude induced during injection. The calculated seismogenic indices agree very well with the expected seismic response to hydraulic fracturing and wastewater disposal and show a strong correlation with tectonically accumulated strain energy. Statistical models based on the seismogenic index can be employed to mitigate the potential risk of large magnitude induced events.
Impact of Anticyclonic Eddies Under Stormy Weather on the Mixed Layer Variability in April South of the Kuroshio Extension
Authors: Ding Yang , Xu Lixiao , Zhang Yang 
Published: March 2021

AbstractSubtropical mode water (STMW) plays an important role in the North Pacific climate system by recording climate variability and by taking in anthropogenic carbon dioxide. A thick STMW forms in anticyclonic eddies (AEs) with deeper mixed layers during winter and early spring. However, the mixed layer depth (MLD) variability and mode water formation in AEs under synoptic weather events are not well known. In this study, we tracked an AE located south of the Kuroshio Extension for several months by 17 Argo floats with daily sampling. We found that the MLD inside the target AE deepened sharply to more than 150 m during storms in April, while the MLD outside had little change and was only 50 m on average. We further compared the different mixed layer deepening processes inside and outside other AEs over the same region based on historical Argo data from 2004 to 2019. Since the relatively weak stratification in AEs is easily destroyed by storms with strong wind bursts and significant surface cooling in early spring, the mixed layer deepening time period lasts longer (December–April) inside AEs than outside AEs (January–March). The mode water ventilation and formation period are correspondingly extended in AEs, with important implications for North Pacific climate variability and the biogeochemical cycle.
The Geomagnetic Kp Index and Derived Indices of Geomagnetic Activity
Authors: Matzka J. , Stolle C. , Yamazaki Y. , Bronkalla O. , Morschhauser A. 
Published: March 2021

AbstractThe geomagnetic Kp index is one of the most extensively used indices of geomagnetic activity, both for scientific and operational purposes. This article reviews the properties of the Kp index and provides a reference for users of the Kp index and associated data products as derived and distributed by the GFZ German Research Centre for Geosciences. The near real‐time production of the nowcast Kp index is of particular interest for space weather services and here we describe and evaluate its current setup.
Discovery of Two Sub‐Volcanic Basins Below the North Atlantic Igneous Province (NAIP), Faroe Platform, NE Atlantic Ocean
Authors: Ólavsdóttir Jana , Stoker Martyn S. , S. Riishuus Morten , Eidesgaard Óluva R. 
Published: March 2021

AbstractThe Faroe Platform lies on the outer continental margin of NW Europe. Its pre‐breakup structural configuration has long been debated as it is entirely buried beneath a thick cover of lower Palaeogene volcanic rocks. Here we present the results of an integrated geological and geophysical study designed to test whether low‐gravity areas on the Faroe Platform are basins inverted during the Neogene, and high‐gravity areas are basement blocks. Based on a series of profiles constructed from forward gravity modeling, our results identify two new sedimentary basins—the Beinta and Kerstin basins—bounded by four basement highs—the West Suðuroy High, East Suðuroy High, Borðoy High, and the Sandoy High. The Beinta and Kerstin basins extend to depths of 8–10 km and 8–9 km, respectively, whereas the tops of the structural highs are located between 3–6 km below the present‐day surface of the platform. Deformation of the A‐horizon, which marks the boundary between pre‐and syn‐breakup volcanism, is consistent with a phase of Miocene‐Pliocene basin inversion, also evident in the adjacent Faroe‐Shetland Basin. Our study also gives indications of cross‐cutting intrusive networks that likely represent part of the magmatic plumbing system in the central part of the Faroe Platform.
Seasonal Performance of a Nonhydrostatic Global Atmospheric Model on a Cubed‐Sphere Grid
Authors: Kim Jung‐Eun Esther , Koo Myung‐Seo , Yoo Changhyun , Hong Song‐You 
Published: March 2021

AbstractThe Korean Integrated Model (KIM), a recently developed nonhydrostatic global atmospheric model over a cubed‐sphere grid, was deployed in April 2020 as an operational weather forecasting model. As its application extends to research and predictions longer than the weather time scale, we evaluated the ability of the KIM on seasonal ensemble simulation for the boreal winter and summer cases with respect to seasonal mean biases. The results are compared with those obtained from a conventional hydrostatic spectral model, which has been widely used for seasonal simulations and in climate research. To isolate the origin of the error sources, the same physics packages is used in both the KIM and the reference models. The simulated mean states are very close to the reanalysis for the selected cases. Most large‐scale fields from the KIM are comparable to those from the reference model, which implies that the general features of large‐scale variables and precipitation are highly governed by physical parameterizations, and that the physics‐dynamics coupling is stable in a long‐term simulation. Large‐scale tropical circulations, such as the Hadley and Walker circulations, need to be improved for applications related to future changes and climate projections. Moreover, the results reveal that the simulated global precipitation band is misplaced and the heat fluxes over oceans are relatively misrepresented near the eastern boundaries of tropical and subtropical regions. This analysis suggests the necessity of realistic atmosphere‐ocean interactions that reflect ocean overturning circulation via ocean coupling as well as the refinement of deep and shallow convection schemes.
Halogen (F, Cl) Concentrations and Sr‐Nd‐Pb‐B Isotopes of the Basaltic Andesites From the Southern Okinawa Trough: Implications for the Recycling of Subducted Serpentinites
Authors: Zhang Yuxiang , Gaetani Glenn , Zeng Zhigang , Monteleone Brian , Yin Xuebo , Wang Xiaoyuan , Chen Shuai 
Published: March 2021

AbstractSerpentinites are increasingly recognized as playing an important role in the global geochemical cycle. However, discriminating the contributions of serpentinites to arc magmas from those of other subduction components is challenging. The Okinawa Trough is a back‐arc basin developed behind the Ryukyu subduction zone, where magmas are extensively affected by sediment subduction. In this study, we reported the F‐Cl concentrations and Sr‐Nd‐Pb‐B isotopes of basaltic andesites from the Yaeyama Graben, Yonaguni Graben, and Irabu Knoll in the southern Okinawa Trough. The Irabu Knoll lavas show the most enrichment of fluid‐mobile elements and F ± Cl, and have the heaviest B isotopes (δ11B: +6.6 ± 1.5‰). They also have decoupled Sr‐Nd isotopes: higher 87Sr/86Sr (∼0.7049) but have no obvious decrease of 143Nd/144Nd (∼0.5128). Results from slab dehydration modeling and mixing calculations suggest that the heavy δ11B in the Irabu Knoll lavas is not consistent with fluids derived from altered oceanic crust (AOC), sediments, or wedge serpentinites (formed in the mantle wedge), but rather from slab serpentinites (formed within the subducting plate); sediments control the subduction input of Nd, whereas the decoupled Sr‐Nd isotopes are most likely due to the excess radiogenic Sr carried by AOC fluids. Our results imply that recycling of serpentinite fluids and AOC fluids are usually coupled in subduction zones, as the arc lavas influenced by subducted serpentinite generally show Sr‐Nd isotopes decoupling. The large variation of Sr‐Nd‐B isotopes observed in a relatively localized area is consistent with a focused migration through the mantle wedge of components from multiple sources.
Greenspace redevelopment, pressure of displacement, and sleep quality among Black adults in Southwest Atlanta
Authors: Williams Patrice C. , Krafty Robert , Alexander Terrence , Davis Zipporah , Gregory Akil-Vuai , Proby Raven , Troxel Wendy , Coutts Christopher 
Published: March 2021

Abstract
Background
Little is known on how greenspace redevelopment—creating or improving existing parks and trails—targeted for low-income and/or majority Black neighborhoods could amplify existing social environmental stressors, increase residents’ susceptibility to displacement, and impact their sleep quality.

Objective
To examine the relationship between social environmental stressors associated with displacement and sleep quality among Black adults.

Methods
Linear regression models were employed on survey data to investigate the association between social environmental stressors, independently and combined, on sleep quality among Black adults residing in block groups targeted for greenspace redevelopment (i.e., exposed) and matched with block groups that were not (i.e., unexposed).

Results
The independent associations between everyday discrimination, heightened vigilance, housing unaffordability, and subjective sleep quality were not modified by greenspace redevelopment, controlling for other factors. The association between financial strain and subjective sleep quality was different for exposed and unexposed participants with exposed participants having a poorer sleep quality. The combined model revealed that the association between financial strain and sleep quality persisted. However, for different financial strain categories exposed participants slept poorer and/or better than unexposed participants.

Significance
Our findings suggest a nuanced relationship between social environmental stressors, pressure of displacement related to greenspace redevelopment, and sleep quality among Black adults.
Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells
Authors: Blokzijl-Franke Sasja , Ponsioen Bas , Schulte-Merker Stefan , Herbomel Philippe , Kissa Karima , Choorapoikayil Suma , den Hertog Jeroen 
Published: March 2021

AbstractHematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial hematopoietic transition (EHT). We investigated the ontogeny of HSPCs in mutant zebrafish embryos lacking functional pten, an important tumor suppressor with a central role in cell signaling. Through in vivo live imaging, we discovered that in pten mutant embryos a proportion of the HSPCs died upon emergence from the VDA, an effect rescued by inhibition of phosphatidylinositol-3 kinase (PI3K). Surprisingly, inhibition of PI3K in wild-type embryos also induced HSPC death. Surviving HSPCs colonized the caudal hematopoietic tissue (CHT) normally and committed to all blood lineages. Single-cell RNA sequencing indicated that inhibition of PI3K enhanced survival of multipotent progenitors, whereas the number of HSPCs with more stem-like properties was reduced. At the end of the definitive wave, loss of Pten caused a shift to more restricted progenitors at the expense of HSPCs. We conclude that PI3K signaling tightly controls HSPCs survival and both up- and downregulation of PI3K signaling reduces stemness of HSPCs.