bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior spinal fixation using penetrating endplate screws in patients with diffuse idiopathic skeletal hyperostosis–related thoracolumbar fractures
Authors: Hishiya Takahisa , Ishikawa Tetsuhiro , Ota Mitsutoshi 
Published: April 2021

OBJECTIVE
Diffuse idiopathic skeletal hyperostosis (DISH)–related vertebral fractures essentially require operative treatment due to severe fracture site instability and high potential risk of posttraumatic neurological deficit. However, the optimal surgical procedure remains unclear. The purpose of this study was to assess the efficacy of posterior spinal fixation with penetrating endplate screws (PESs) for DISH-related thoracolumbar fractures.

METHODS
The authors conducted a retrospective, single-center, observational study. They included data from 26 consecutive patients with DISH-related thoracolumbar fractures who were treated with posterior spinal fixation using either conventional pedicle screws (PS group, n = 8) or a combined PES technique (PES group, n = 18) between 2013 and 2019. Age, sex, BMI, bone mineral density, fracture level, use of antithrombotic drug, blood loss, operation time, fixation range, perioperative American Spinal Injury Association Impairment Scale score, implant failure, revision surgery, complications, and mortality were compared. The authors also evaluated screw loosening and bone healing on radiographs and CT scans.

RESULTS
More patients had vertebral fractures in the lumbar spine in the PS group than in the PES group (3 vs 0; p = 0.019). Patients in the PES group had less blood loss (63 vs 173 ml; p = 0.048) and shorter range of fixation (5 vs 5.5 levels; p = 0.041). The screw loosening rate was significantly lower in the PES group than in the PS group (3% vs 49%; p < 0.001).

CONCLUSIONS
Posterior spinal fixation using a PES technique may be an ideal surgical procedure for thoracolumbar fractures with DISH, providing more rigid and less invasive fixation than PS.
Clinical outcomes of nonoperatively managed degenerative cervical myelopathy: an ambispective longitudinal cohort study in 117 patients
Authors: Martin Allan R. , Kalsi-Ryan Sukhvinder , Akbar Muhammad A. , Rienmueller Anna C. , Badhiwala Jetan H. , Wilson Jefferson R. , Tetreault Lindsay A. , Nouri Aria , Massicotte Eric M. , Fehlings Michael G. 
Published: April 2021

OBJECTIVE
Degenerative cervical myelopathy (DCM) is among the most common pathologies affecting the spinal cord but its natural history is poorly characterized. The purpose of this study was to investigate functional outcomes in patients with DCM who were managed nonoperatively as well as the utility of quantitative clinical measures and MRI to detect deterioration.

METHODS
Patients with newly diagnosed DCM or recurrent myelopathic symptoms after previous surgery who were initially managed nonoperatively were included. Retrospective chart reviews were performed to analyze clinical outcomes and anatomical MRI scans for worsening compression or increased signal change. Quantitative neurological assessments were collected prospectively, including modified Japanese Orthopaedic Association (mJOA) score; Quick-DASH; graded redefined assessment of strength, sensation, and prehension–myelopathy version (GRASSP–M: motor, sensory, and dexterity); grip dynamometer; Berg balance scale score; gait stability ratio; and gait variability index. A deterioration of 10% was considered significant (e.g., a 2-point decrease in mJOA score).

RESULTS
A total of 117 patients were included (95 newly diagnosed, 22 recurrent myelopathy), including 74 mild, 28 moderate, and 15 severe cases. Over a mean follow-up of 2.5 years, 57% (95% CI 46%–67%) of newly diagnosed patients and 73% (95% CI 50%–88%) of patients with recurrent DCM deteriorated neurologically. Deterioration was best detected with grip strength (60%), GRASSP dexterity (60%), and gait stability ratio (50%), whereas the mJOA score had low sensitivity (33%) in 50 patients. A composite score had a sensitivity of 81% and a specificity of 82%. The sensitivity of anatomical MRI was 28% (83 patients).

CONCLUSIONS
DCM appears to have a poor natural history; however, prospective studies are needed for validation. Serial assessments should include mJOA score, grip strength, dexterity, balance, and gait analysis. The absence of worsening on anatomical MRI or in mJOA scores is not sufficient to determine clinical stability.
IMPLEMENTASI KEBIJAKAN PENYIANGAN KOLEKSI DI UPT PERPUSTAKAAN UNIVERSITAS MUHAMMADIYAH MATARAM
Authors: Ridwan Ridwan , Rohana Rohana 
Published: April 2021

Hasil penelitian menunjukkan bahwa UPT Perpustakaan Universitas Muhammadiyah Mataram sampai saat ini belum memiliki kebijakan secara tertulis dalam melakukan proses penyiangan koleksi perpustakaan. Proses penyiangan di perpustakaan Universitas Muhammadiyah Mataram akan diadakan setiap tiga tahun sekali bersamaan dengan proses Stock Opname. Perpustakaan UMMAT tidak memiliki tim khusus untuk melakukan penyiangan, yang berwenang melakukan penyiangan koleksi adalah pihak perpustakaan dan dibantu oleh mahasiswa prodi D3 perpustakaan, dikarenakan kurangnya tenaga pengelola perpustakaan. Kendala yang dialami oleh perpustakaan Universitas Muhammadiyah Mataram dalam melakukan penyiangan diantaranya adalah, waktu untuk melakukan penyiangan maupun stok opname harus bersamaan dengan hari libur mahasiswa, masih banyak buku-buku yang sudah tidak layak pakai tetapi masih dibutuhkan oleh pemustaka sehingga proses penyiangan ini terhambat karena harus memilih buku apa yang harus di siangi, kurangnya tenaga pengelola perpustakaan sehingga tidak ada yang menangani khusus proses penyiangan koleksi perpustakaan, dan kegiatan ini tidak ada dalam aturan tertulis sehingga tidak ada anggaran khusus.
An adaptive QoS supportive approach for user based services using Krill Herd Approach over Internet of Things (KHAI)
Authors: Padmavathi V. , Saminathan R. , Selvamuthukumaran S. 
Published: April 2021

The demand for a providing QoS adaptive routing over IoT networks is always a challenge among current research community. This research work KHAI proposes a framework for QoS-adaptive routing approach, which incorporates Krill Herd optimization model over IoT network. Variable QoS user preference and handling differential service types over a scalable IoT network shows that challenge for designing an adaptive QoS is a must. Research survey suggest that major works have been carried out on bandwidth appreciable services and route management approaches. Hence QoS adaptive user defined services, which adapt to variable service priority levels based on user demand and network resource utilization is proposed in this research work. The performance analysis of proposed approach shows an improved throughput of 97.51 Mbps and minimal packet loss of 37.29% over a session in comparison to traditional computational approaches. Considering large scale of interconnected IoT devices, proposed approach delivers near optimal solution of throughput and adaptive utilization of network resources.
The The Effects of Recycled Tire Rubbers and Steel Fibers on the Performance of Self-compacting Alkali Activated Concrete
Authors: Eren Necip Altay , Alzeebaree Radhwan , Çevik Abdulkadir , Niş Anıl , Mohammedameen Alaa , Gülşan Mehmet Eren 
Published: April 2021

In this study, the effects of recycled tire rubbers (RTR) and steel fiber (SF) on the fresh and hardened state properties of the self-compacted alkali activated concrete (SCAAC) were investigated. The ground granulated blast furnace slag, 1 % hooked-end SF, and two types of RTR were utilized. The crumb rubbers (CR) and tire rubber chips (TCR) were used as a substation to natural aggregates at substation levels of 10 % and 15 %. The fresh state performances were evaluated by T50 value, slump flow, V-funnel, and L-Box tests, while mechanical performances were assessed through compressive, flexural, and splitting tensile strength tests. Also, detailed crack and microstructural analyses were conducted. The RTR adversely affected the fresh state properties, which reduced more with SF inclusions. Among the RTR, the TR specimens exhibited lower fresh state performance than the CR specimens. Similar mechanical strengths were obtained on the TR and CR specimens under the same replacement ratios. However, TR specimens exhibited higher deformation capacities than the CR specimens, when SF was utilized. The SCAAC specimens with 1 % SF and 15 % RTR showed more and wider flexural cracks, higher mechanical strength, and deformation capacity, which can be utilized in structural applications, particularly in high seismic zones.
The principles of unique identification of library documents in automatic proximity identification systems
Authors: Timoshenko I. V. 
Published: April 2021

The author examines prospects for applying the full-range standard functionalities of automatic proximity identification systems. He discusses their performance capabilities for unique identification of library documents in the library information systems of different scaling plateau; using standards library standard identifiers in non-library information systems; the functionality of automatic proximity identification systems for library automation. The RFID technology plays the key role in developing automatic proximity identification. The library application features are examined from the viewpoint of harmonization with international and RF standards of automatic proximity identification systems. Developing the Internet of things concept gives into a new communication environment emerging based on the automatic proximity identification. This technology's standard capabilities may significantly expand the functionality of library automation. Integration of library information systems with global automatic identification systems is on agenda which is evidenced by the logic of development of information systems and library RFID.The article is written within the framework of the State Order № 730000F.99.1.BV09АА00006.
O uso da técnica de micromarsupialização modificada no tratamento de rânula bilateral: Relato de caso clínico
Authors: Gonzalez Abrian Andre , Nascimento Amanda Silva , Lima Ana Cléa Aguiar de Araújo , Lago Carlos Augusto Pereira do , Brito Felipe Ricardo Cisneiros , Santos Greiciane Miguel de Azevedo , Pinto João Victor Souza , Cabral Leandro Pimentel , Silva Filho Nilton José da , Pinto Priscilla Sarmento , Silva Ronaldo Gabriel Martiniano da , Marinho Neto Walter Ferreira 
Published: April 2021

Os fenômenos de extravasamento de muco resultam de um trauma mecânico ao ducto excretor de uma glândula salivar, levando ao acúmulo de mucina no tecido conjuntivo subjacente. São classificados em mucocele e rânula, a depender de sua localização. O tratamento é cirúrgico, variando da marsupialização, remoção definitiva de lesão, além de outras técnicas de descompressão. Relatar um caso clínico de rânula bilateral tratada através da técnica da micromarsupialização modificada com fio de algodão 0. Paciente do sexo feminino, 84 anos, leucoderma e hipertensa deu entrada no serviço de urgência/emergência do Hospital da Restauração Governador Paulo Guerra – Recife – Pernambuco – Brasil apresentando aumento de volume assintomático bilateral em região de assoalho bucal e discreta disfagia. De acordo com o conjunto de avaliações clínicas (anamnese e exames físicos gerais e loco-regionais) e complementares, obteve-se como diagnóstico uma lesão patológica advinda do extravasamento de muco para os tecidos adjacentes denominada rânula, no qual apresentou uma resposta clínica satisfatória ao tratamento de micromarsupialização modificada com fio de algodão número 0. A técnica da micromarsupialização modificada no tratamento de rânula mostrou sucesso do tratamento, e possui a vantagem de ser um procedimento de simples realização, tempo operatório reduzido, pouco invasivo e com menor risco de danos a estruturas anatômicas.
High Anti-Leishmania IgG Antibody Levels Are Associated With Severity of Mucosal Leishmaniasis
Authors: de Lima Clara Mônica F. , Magalhães Andrea S. , Costa Rúbia , Barreto Carolina C. , Machado Paulo R. L. , Carvalho Edgar M. , Lessa Marcus M. , Carvalho Lucas P. 
Published: April 2021

BackgroundMucosal leishmaniasis (ML), the most inflammatory form of tegumentary leishmaniasis, is predominantly caused by Leishmania braziliensis. The disease is characterized by the development of lesions, mainly in the nasal mucosa. An exacerbated inflammatory response has been associated with the presence of destructive and disfiguring lesions, with stages of severity ranging from small nodulations to the complete destruction of the nasal pyramid architecture. As Leishmania is an intracellular parasite, most immunological studies have emphasized the cell-mediated immune response, while relatively few studies aimed to investigate the role antibodies in protection against, or the pathology of ML.MethodsPatients with a confirmed diagnosis of ML were classified according to clinical staging criteria. Serum levels of Leishmania-specific IgG, IgG1 and IgG2 antibodies were determined by ELISA before and after treatment with antimony or antimony plus pentoxifylline.ResultsPatients in stages IV and V produced higher concentrations of IgG and IgG1 antibodies when compared to those in stage I and II. Significant reductions were seen in the concentrations of IgG and IgG2 antibodies in most patients who responded well to treatment.ConclusionsOur data demonstrate an association between IgG antibody titers and the severity of mucosal disease. The observed reduction in antibody production after successful treatment in most patients preliminarily indicates that these tests can be used to aid in the assessment of therapeutic response.
Synovial Immunohistological Biomarkers of the Classification of Undifferentiated Arthritis Evolving to Rheumatoid or Psoriatic Arthritis
Authors: Cuervo Andrea , Celis Raquel , Julià Antonio , Usategui Alicia , Faré Regina , Ramírez Julio , Azuaga Ana Belen , Lorenzo Andrés , Sanmartí Raimon , Pablos José L. , Cañete Juan D. 
Published: April 2021

Background: Undifferentiated arthritis (UA) is defined as an inflammatory arthritis that does not fulfill criteria for a definite diagnosis. Delay in reaching a specific diagnostic and therapy may lead to impaired functional outcomes. Our aim was to identify synovial biomarkers associated with definitive diagnostic classification in patients with UA.Methods: DMARD-naïve UA patients with available initial synovial tissue (ST) and a final diagnosis of rheumatoid arthritis (RA) or psoriatic arthritis (PsA) during follow-up were included and compared with patients with well-defined disease (RA or PsA). Clinical, arthroscopic, and pathological data were compared between groups. Pathology included quantitative immunohistochemical (IHC) analysis of cell types and human interferon-regulated MxA. Principal component analysis (PCA) was performed to extract disease patterns.Results: One hundred and five patients were included: 31 patients with DMARD-naïve UA (19 evolving to RA and 12 to PsA during a median follow up of 7 years), 39 with established RA, and 35 with established PsA. ST from the UA group showed higher macrophage density compared with the established RA and PsA groups. Patients with UA evolving to RA (UA-RA) showed higher MxA expression and CD3+ T-cell density compared with established RA. UA patients evolving to PsA (UA-PsA) showed increased vascularity and lining synovial fibroblast density compared with established PsA. Synovitis of UA-PsA patients showed more mast cells and lining fibroblasts compared with UA-RA. No between-group differences in local or systemic inflammation markers were found.Conclusions: Our results show differences in the cellular composition of UA synovium compared with RA and PsA, with higher density of the cellular infiltrate in the UA groups. Initial expression of the interferon inducible gene MxA could be a biomarker of progression to RA, while higher mast cell and fibroblastic density may be associated with PsA progression.
Exploration of High-Grade Transformation and Postoperative Radiotherapy on Prognostic Analysis for Primary Adenoid Cystic Carcinoma of the Head and Neck
Authors: Zhu Yuelu , Zhu Xinyi , Xue Xuemin , Zhang Ye , Hu Chunfang , Liu Wenchao , Lu Haizhen 
Published: April 2021

BackgroundDespite Adenoid cystic carcinoma (ACC) with cribriform or tubular components being recognized as a potentially indolent malignancy, ACC displaying solid or, more rarely, high-grade transformation (HGT) components is considered a more aggressive variant of the disease. As it is difficult to measure the proportion of the solid component objectively, and the role of HGT in the current grading system remains unclear, the prognostic influence of tumor grading remains controversial. In addition, postoperative radiotherapy (PORT) has been proven to be effective in local control of ACC of the head and neck (ACCHN) with a high rate of nerve invasion and close surgical margin. However it remains to be explored that whether PORT could improve the survival of patients with ACC, particularly those with HGT.MethodsA series of 73 surgically treated primary ACCHN cases were retrospectively accessed. Immunohistochemical staining was performed to observe the biphasic ductal-myoepithelial differentiation and to identify the HGT components of ACC for tumor grading. The correlation between tumor grading and clinicopathological characteristics was analyzed. Univariate and multivariate prognostic analysis were performed for progression-free survival (PFS) and overall survival (OS).ResultsOf the 73 included cases, 47 were grade I-II ACC and 26 were grade III ACC. Among the grade III cases, 14 with loss of biphasic ductal-myoepithelial differentiation identified by immunostaining were classified as HGT, and could be distinguished from conventional grade III cases. These HGT cases were correlated with a high propensity of lymph node metastases and more advanced stage. Univariate analysis demonstrated that tumor grading, perineural invasion, T stage, stage groups, and PORT were predictors for PFS, whereas tumor grading, margin status, and PORT were predictors for OS. However, only tumor grading and PORT were independent predictors for PFS and OS. The patients with HGT had significantly worse prognosis than those with conventional ACC. Moreover, disease progression tended to occur more frequently in younger patients. Among the patients with HGT, those who received PORT had a longer median survival time than those who did not.ConclusionHGT ACC identified by loss of biphasic differentiation should be considered in tumor grading. Tumor grading and PORT were independent predictors for disease progression and OS in surgically treated ACCHN patients.
Long Non-coding RNA LINC02474 Affects Metastasis and Apoptosis of Colorectal Cancer by Inhibiting the Expression of GZMB
Authors: Du Tiantian , Gao Qinglun , Zhao Yinghui , Gao Jie , Li Juan , Wang Lili , Li Peilong , Wang Yunshan , Du Lutao , Wang Chuanxin 
Published: April 2021

BackgroundColorectal cancer (CRC) is one of the most frequently diagnosed malignancies. Metastasis is the main event that impedes the therapeutic effect on CRC, and its underlying mechanisms remain largely unclear. LINC02474 is a novel long noncoding RNA (lncRNA) associated with metastasis of CRC, while little is known about how LINC02474 regulates these malignant characteristics.MethodsExpressions of LINC02474 and granzyme B (GZMB) were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) or Western blotting analysis. Cell metastasis was detected by transwell assay and metastatic nude mouse model, and apoptosis was determined by Western blotting analysis and flow cytometry. Besides, the interaction between LINC02474 and GZMB was detected by dual-luciferase reporter assays.ResultsThe expression of LINC02474 was significantly up-regulated in CRC tissues. Moreover, depletion of LINC02474 damaged the metastatic abilities of CRC cells in vivo and in vitro while boosting apoptosis. Besides, up-regulation of LINC02474 could promote migration and invasion, while apoptosis was inhibited in CRC cells. Besides, down-regulation of LINC02474 promoted the expression of GZMB, and interference of GZMB could increase the metastatic abilities of CRC cells while reducing apoptosis. Furthermore, LINC02474 was related to the transcriptional repression of GZMB in CRC cells determined by the dual-luciferase reporter assay.ConclusionsThe findings revealed that a novel lncRNA, LINC02474, as an oncogene, could promote metastasis, but limit apoptosis partly by impeding GZMB expression in CRC. Besides, LINC02474 had the potential to be used as a biomarker in the prognosis of CRC.
Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior
Authors: Zhang Fushen , Huang Shihao , Bu Haiyan , Zhou Yu , Chen Lixiang , Kang Ziliu , Chen Liangpei , Yan He , Yang Chang , Yan Jie , Jian Xiaohong , Luo Yixiao 
Published: April 2021

Drug addiction is considered maladaptive learning, and drug-related memories aroused by the presence of drug related stimuli (drug context or drug-associated cues) promote recurring craving and reinstatement of drug seeking. The mammalian target of rapamycin signaling pathway is involved in reconsolidation of drug memories in conditioned place preference and alcohol self-administration (SA) paradigms. Here, we explored the effect of mTOR inhibition on reconsolidation of addiction memory using cocaine self-administration paradigm. Rats received intravenous cocaine self-administration training for 10 consecutive days, during which a light/tone conditioned stimulus was paired with each cocaine infusion. After acquisition of the stable cocaine self-administration behaviors, rats were subjected to nosepoke extinction (11 days) to extinguish their behaviors, and then received a 15 min retrieval trial with or without the cocaine-paired tone/light cue delivery or without. Immediately or 6 h after the retrieval trial, rapamycin (10 mg/kg) was administered intraperitoneally. Finally, cue-induced reinstatement, cocaine-priming-induced reinstatement and spontaneous recovery of cocaine-seeking behaviors were assessed in rapamycin previously treated animals, respectively. We found that rapamycin treatment immediately after a retrieval trial decreased subsequent reinstatement of cocaine seeking induced by cues or cocaine itself, and these effects lasted at least for 28 days. In contrast, delayed intraperitoneal injection of rapamycin 6 h after retrieval or rapamycin injection without retrieval had no effects on cocaine-seeking behaviors. These findings indicated that mTOR inhibition within the reconsolidation time-window impairs the reconsolidation of cocaine associated memory, reduces cocaine-seeking behavior and prevents relapse, and these effects are retrieval-dependent and temporal-specific.