bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral Facial Asymmetry in a 40 BCE Roman Carved Head
Authors: Nerlich Andreas G. , Appenzeller Otto , Perciaccante Antonio , Galassi Francesco Maria , Varotto Elena , Bianucci Raffaella 
Published: October 2021

Abstract
We describe the peculiar facial morphology of a carved head dating to the end of the Roman Republican period (40 BCE) which displays evident unilateral asymmetry. A comprehensive discussion of the different etiologies is provided and a contextualization of this condition in the broader frame of Roman artistic verism is offered. This case study contributes to the knowledge of disease presentation in the ancient world, with a special focus on the anatomy of soft tissue pathology.
Evaluating Sensory Nerve Outcomes After Horizontal Osteotomy for Mandibular Distraction in Infant Robin Sequence Patients
Authors: Do Nicholas T. , Denny Arlen D. , Klement Kristen A. 
Published: October 2021

Abstract
There has yet to be a consensus on the appropriate technique for mandibular distraction in the infant Pierre Robin population nor is their sufficient data on sensory nerve outcomes. The purpose of this study is to validate the safety of the horizontal osteotomy by: (1) determining mandibular foramen location in infant Pierre Robin patients relative to the dentoalveolar plane and (2) evaluate long-term function of the inferior alveolar nerve in previously distracted Pierre Robin patients. Preoperative 3D Computed tomography (CT) scans of Pierre Robin patients < 1 year old were reviewed. A line at the level of the mandibular dentoalveolar plane was drawn across the lingual surface of the ramus and the distance to the mandibular foramen was then measured. Semmes-Weinstein monofilaments of the lower lip and chin bilaterally was performed on mandibular distraction patients in clinic. Inclusion criteria was patients >6 years of age having undergone bilateral mandibular distraction at <1 year of age. Fifteen patients’ CT studies were examined. The mandibular foramen was consistently below the level of the dentoalveolar plane at an average distance of 4.7 mm. Eight patients were included in the prospective arm. Average age was 12.2. All patients had normal sensation at 2.83 through all areas. The mandibular foramen reliably exists below the dentoalveolar plane. In addition, all patients reviewed postoperatively with >10 years of follow up demonstrated normative sensation. The horizontal corticotomy performed just above the mandibular dentoalveolar plane spares the inferior alveolar nerve in young Pierre Robin patients undergoing distraction.
A New Approach for Timely Systematic Reviews of Rapidly Evolving Research: Identifying Evidence in Which We Can Place Our Confidence
Authors: Tong Jiayi , Hubbard Rebecca A. , Saine M. Elle , Xu Hua , Zuo Xu , Kimmel Stephen E. , Cuker Adam , Chen Yong 
Published: October 2021

ABSTRACTCoronavirus disease of 2019 (COVID-19) has impacted the world in unprecedented ways since first emerging in December 2019. In the last two years, the scientific community has made an enormous effort to understand COVID-19 and potential interventions. As of June 15, 2021, there were more than 140,000 COVID-19 focused manuscripts on PubMed and preprint servers, such as medRxiv and BioRxiv. Preprints, which constitute more than 15% of all manuscripts, may contain more up-to-date research findings compared to published papers, due to the sometimes lengthy timeline between manuscript submission and publication. Including preprints in systematic reviews and meta-analyses thus has the potential to improve the timeliness of reviews. However, there is no clear guideline on whether preprints should be included in systematic reviews and meta-analyses.Using a prototypical example of a rapid systematic review examining the comparative effectiveness of COVID-19 therapeutics, we propose including all preprints in the systematic review by assigning them a weight we term the “confidence score”. Motivated by our observation that, unlike the traditional journal submission process which is unobserved, the timeline from submission to publication for a preprint can be observed and can be modeled as a time-to-event outcome. This observation provides a unique opportunity to model and quantify the probability that a preprint will be published, which can be used as a confidence score to weight preprints in systematic reviews and meta-analyses.To obtain the confidence score, we propose a novel survival cure model, which incorporates both the time from posting to publication for a preprint, and key characteristics of the study described in the content of the preprint. Using meta data from 158 preprints on evaluating therapeutic options for COVID-19 posted through 09/03/2020, we demonstrate the utility of the confidence score in weighting of preprints in a systematic review. Our proposed method has the potential to advance timely systematic reviews of the evidence examining COVID-19 and other clinical conditions with rapidly evolving evidence bases by providing an approach for inclusion of unpublished manuscripts.
A comprehensive framework to estimate the frequency, duration and risk factors for diagnostic delays using simulation-based methods
Authors: Miller Aaron C , Cavanaugh Joseph E , Arakkal Alan T , Koeneman Scott H , Polgreen Philip M 
Published: October 2021

AbstractThe incidence of diagnostic delays is unknown for many diseases and particular healthcare settings. Many existing methods to identify diagnostic delays are resource intensive or inapplicable to various diseases or settings. In this paper we propose a comprehensive framework to estimate the frequency of missed diagnostic opportunities for a given disease using real-world longitudinal data sources. We start by providing a conceptual model of the disease-diagnostic, data-generating process. We then propose a simulation-based method to estimate measures of the frequency of missed diagnostic opportunities and duration of delays. This approach is specifically designed to identify missed diagnostic opportunities based on signs and symptoms that occur prior to an initial diagnosis, while accounting for expected patterns of healthcare that may appear as coincidental symptoms. Three different simulation algorithms are described for implementing this approach. We summarize estimation procedures that may be used to parameterize the simulation. Finally, we apply our approach to the diseases of tuberculosis, acute myocardial infarction, and stroke and evaluate the estimated frequency and duration of diagnostic delays for these diseases. Our approach can be customized to fit a range of disease and we summarize how the choice of simulation algorithm may impact the resulting estimates.
Computational correction of cell-specific gene-independent effects in CRISPR-Cas9 essentiality screens: REStricted CUbic SplinEs with Mixed Models (RESCUE-MM)
Authors: Dias Julie A. , Deng Shibing , Bonato Vinicius 
Published: October 2021

AbstractIncreased gene copy number has been associated with a greater antiproliferative response upon genome editing, regardless of the true essentiality profile of the targeted gene. Many methods have been developed to adjust for genomic copy number technical artifacts. Existing methods use a two-step correction by pre-processing the data prior to the final analysis. It has been shown that two-step corrections can produce unreliable results, due to the creation of a correlation structure in the corrected data. If this structure is unaccounted for, gene-essentiality levels can be inflated or underestimated, affecting the False Discovery Rate (FDR). We propose a one-step correction using restricted cubic splines (RCS) to be a simpler alternative which reduces the bias in downstream analyses. Moreover, most existing methods combine guide-level results to yield gene-level estimates which can misrepresent the true gene essentiality profile depending on the guide-averaging method. Our model-based approach (RESCUE-MM) for copy number correction provides a more flexible framework that allows for guide-level essentiality estimation while accommodating more complex designs with grouped data. We provide comparisons to existing copy number correction methods and suggest how to include copy number adjustment in a one-step correction fashion in multiple experimental designs.
ICA treatment diabets induced bone loss via primary cilia/Gli2/Osteocalcin signaling pathway
Authors: Liu Jie , Wu Xiangmei , Deng Xiaoyan , zhu Huifang , Wang Tingting , Wang Maorong , Yang Shengyong , Xu Jie , Chen Qian , Li Mengxue , Liu Xianjun , Wang Changdong 
Published: October 2021

AbstractDiabetes mellitus, as a metabolic system disorder disease, aggravates the disease burden of patients and affects the quality of human life. Diabetes-associated bone complications lead to decreased bone mechanical strength and osteoporosis. Evidences show that chronic hyperglycemia and metabolic intermediates, such as inflammatory factor, reactive oxygen species (ROS) and advanced glycation end products (AGEs), are regarded as dominant hazardous factors of primary cilia/Gli2 signal disorders. Case studies have demonstrated abnormal bone metabolism in diabetics, however, how diabetes damages primary cilia/Gli2 signal is largely unknown. Therefore, we studied the effects of diabetes on femoral primary cilia by establishing a Streptozocin (STZ)-induced diabetic (Sprague Dawley) SD rat model and diabetic bone loss cell model in vitro. Our results confirmed that diabetes impaired femur primary cilia, osteoblast differentiation and mineralization by inhibiting primary cilia/Gli2 signaling pathway, additionally, Icariin(ICA) treatment could rescue the impairment of osteoblast differentiation caused by high glucose medium in vitro. ICA activated primary cilia/Gli2/osteocalcin signaling pathway of osteoblasts by protecting primary cilia from glucotoxicity imposed by diabetes, intact primary cilia could be as anchoring sites, in which Gli2 was processed and modified, and matured Gli2 entered the nucleus to initiate downstream osteocalcin gene transcription. Additionally, ICA inhibited ROS production of mitochondria, thus balanced mitochondrial energy metabolism and oxidative phosphorylation. All results suggest that ICA can protect the primary cilia and mitochondria of osteoblast by reducing intracellular ROS, thereby recover primary cilia/Gli2 signaling pathway to facilitate osteoblast differentiation and mineralization, suggesting that ICA has potential as a novel type of drug treating bone loss induced by diabetes.
Modeling returns of sukuk and related indices with system GMM: evidence from the MENA region
Authors: Seth Neha , Singhania Monica , Siddiqui Saif 
Published: October 2021

Purpose
The paper aims to resolve the ongoing issue of asset pricing in indexed based investments, primarily in Sukuks. It is to be done by modeling the returns of S&P MENA (Middle East and North Africa) Sukuk index (SPS), S&P MENA bonds indices (SPM) and Dow Jones MENA (DJM) equity index using system equations and to find out cointegration among them.

Design/methodology/approach
In this study, daily data of stated regional market indices, from the month July 2013 to June 2017, are analyzed using the cointegration model and Generalized Method of Moments (GMM) estimation.

Findings
Findings revealed through cointegration test that indices are found to be not integrated in the long run; however, in short run, DJM is having one way relation with other two indices, and SPM and SPS are having unidirectional relation. The results of the GMM model show that SPS is significant in influencing SPM and vice-versa, and rest other variables are insignificant in influencing each other systems equations.

Originality/value
There is ample work available on various Islamic indices, but there is no study found on the MENA (Middle East and North Africa) Equity, MENA Bond and MENA Sukuk indices together.
Antecedents and consequences of compulsive buying behaviour: the moderating effect of financial management
Authors: Owusu Godfred Matthew Yaw , Amoah Bekoe Rita , Arthur Miriam , Koomson Theodora Aba Abekah 
Published: October 2021

PurposeThis paper investigates the determinants of compulsive buying behaviour (CBB) and ascertains the effect of CBB on the propensity of an individual to be dependent on loans and fall into financial trouble. The study additionally examines the moderating effect of financial management on the hypothesized relationships.Design/methodology/approachThe survey method of research was adopted using questionnaires as the principal means of data collection. The predicted relationships of the study were tested using the partial least square structural equation modelling technique.FindingsThe authors’ results suggest materialism, socioeconomic status and financial management skills of an individual are significant predictors of CBB. The authors also find CBB to be positively associated with loan dependence and the authors’ analysis suggests financial management skills moderate the hypothesized relationships.Social implicationsFindings of this study suggest buying compulsively increases the risks of over-dependence on loans and can be indirectly associated with the risk of individuals falling into financial trouble.Originality/valueThe findings highlight the adverse effects of CBB on loan dependence and financial trouble and the moderating effect of financial management on the dominant factors that influence CBB.
Stakeholder engagement in sustainability reporting by Fortune Global 500 companies: a call for embeddedness
Authors: Ardiana Putu Agus 
Published: October 2021

Purpose
The purpose of this paper is to ascertain whether Fortune Global 500 companies embed stakeholder engagement in their sustainability reporting.

Design/methodology/approach
Quantitative and qualitative content analyses were undertaken on 646 sustainability reports written in English over the period from 2015 to 2017.

Findings
This research found a low level of stakeholder engagement disclosures and scant evidence that sustainability disclosures were drawn upon stakeholder engagement practices. The findings indicate that stakeholder engagement was loosely embedded in sustainability reporting.

Research limitations/implications
Sustainability reports are the sole unit of analysis. Besides, this research is limited to a sample of companies and to a specific period, which limits the generalisation of the research findings.

Practical implications
Embedding stakeholder engagement in sustainability reporting holds companies accountable to their stakeholders. This is because the companies’ sustainability disclosures acknowledge the stakeholders’ concerns and information about the stakeholder engagement methods deployed to address those concerns.

Social implications
Stakeholder engagement promotes accountability by encouraging stakeholders to convey their opinions about corporate sustainability, participate in decision-making processes that impact them, and partake in defining the contents of sustainability reports.

Originality/value
This paper provides insights into the need to link sustainability disclosures with stakeholder engagement disclosures, by articulating who the relevant stakeholders are and how they are engaged on the various sustainability topics – rather than conceiving them to be separate and independent disclosures in a sustainability report.
Effect of processing method on quality characteristics of harit soybean (glycine max): in vitro protein digestibility, hplc, ftir analysis
Authors: Kathuria Deepika , Dhiman Anju K. , Attri Surekha , Kumar Manish 
Published: October 2021

Purpose
Soybean is potentially a rich source of protein and lipids along with isoflavone. However, the use of soybean is limited due to presence of anti-nutritional factors such as trypsin inhibitor, phytic acid, etc. The present study aimed at evaluation of Harit soya seeds of different treatments such as soaking, dehulling, germination, soaking+roasting and roasting in order to enhance its quality.

Design/methodology/approach
Harit soya seeds were utilized were soaked overnight and subjected for dehulling, germination for 3 days as well as roasting followed by drying to obtain fine powder for quality evaluation.

Findings
Dehulling and germination produce significant (p < 0.01) increase in protein, crude fiber, total chlorophyll, ascorbic acid, total phenolics, flavonoids and isoflavones while fat was decreased non-significantly. The highest value of 12.4 mg/100g, 5.3 mgGAE/g and 6.6 mg/g for ascorbic acid, total phenolics and isoflavones was found in germinated seeds. Also, the effect of soaking, roasting and their combination lead to significant decrease in the functional properties of the seeds. Anti-nutritional factors were significantly (p < 0.01) reduced in all forms of treated seeds while pepsin and trysin digestibility was enhanced during soaking, dehulling and germination with maximum value of 72.6 and 25.8%, respectively in germinated seeds.

Originality/value
Improvement in quality of evergreen variety of soybean using cost effective traditional methods
A study on the relationship between spectral characterization and composition of plasma in laser additive manufacturing of gradient materials
Authors: Chen Bo , Meng Zheng , Yang Kai , Yao Yongzhen , Tan Caiwang , Song Xiaoguo 
Published: October 2021

Purpose
The purpose of this paper is to predict and control the composition during laser additive manufacturing, since composition control is important for parts manufactured by laser additive manufacturing. Aluminum and steel functionally graded material (FGM) were manufactured by laser metal deposition, and the composition was analyzed by means of spectral analysis simultaneously.

Design/methodology/approach
The laser metal deposition process was carried out on a 5 mm thick 316L plate. Spectral line intensity ratio and plasma temperature were chosen as two main spectroscopic diagnosis parameters to predict the compositional variation. Single-trace single-layer experiments and single-trace multi-layer experiments were done, respectively, to test the feasibility of the spectral diagnosis method.

Findings
Experiment results showed that with the composition of metal powder changing from steel to aluminum, the spectral intensity ratio of the characteristic spectral line is proportional to the elemental content in the plasma. When the composition of deposition layers changed, the characteristic spectrum line intensity ratio changed obviously. And the linear chemical composition analysis results confirmed the gradient composition variation of the additive manufacturing parts. The results verified the feasibility of composition analysis based on spectral information in the laser additive manufacturing process.

Originality/value
The composition content of aluminum and steel FGM was diagnosed by spectral information during laser metal deposition, and the relationship between spectral intensity and composition was established.
Simple solution to preserve plant samples for microbiome analyses
Authors: Carvalhais Lilia C. , Dennis Paul G. , Poudel Amrit , Birt Henry W. G. , Bhuiyan Shamsul A. , Card Stuart D. , Joyce Priya A. 
Published: October 2021

AbstractCulture‐independent survey techniques are fundamental tools when assessing plant microbiomes. These methods rely on DNA that is carefully preserved after collecting samples to achieve meaningful results. Immediately freezing samples to −80°C after collection is considered one of the most robust methods for preserving samples before DNA extraction but is often impractical. Preservation solutions can solve this problem, but commercially available products are expensive, and there is limited data comparing their efficacy with other preservation methods. In this study, we compared the impact of three methods of sample preservation on plant microbiome surveys: (1) RNAlater, a proprietary preservative, (2) a home‐made salt‐saturated dimethyl sulphoxide preservation solution (DESS), and (3) freezing at −80°C. DESS‐preserved samples, stored at room temperature for up to four weeks, did not show any significant differences to samples frozen at −80°C, while RNAlater inflated bacterial alpha diversity. Preservation treatments did not distinctively influence fungal alpha diversity. Our results demonstrate that DESS is a versatile and inexpensive preservative of DNA in plant material for diversity analyses of fungi and bacteria.
Capmatinib successfully overcomes tepotinib‐induced intolerable peripheral edema
Authors: Kunimasa Kei , Kawamura Takahisa , Tamiya Motohiro , Inoue Takako , Kuhara Hanako , Nishino Kazumi , Kumagai Toru 
Published: October 2021

AbstractIn May 2020 and February 2021, capmatinib and tepotinib, respectively were approved by the Food and Drug Administration (FDA) for the treatment of metastatic non‐small cell lung carcinoma harboring mesenchymal‐epithelial transition (MET) exon 14 skipping alterations. Herein, we present a case of intolerable peripheral edema caused by tepotinib, in which MET inhibitor could be continued by switching to capmatinib. Peripheral edema has been identified as one of the most common adverse events in capmatinib and tepotinib; however, there is no unified management for this adverse event. This is the first report that two MET inhibitors have different effects on the development of peripheral edema, and that the MET inhibitors can be continued by switching these drugs.
Media intervention program for reducing unrealistic optimism bias: The link between unrealistic optimism, well‐being, and health
Authors: Dolinski Dariusz , Kulesza Wojciech , Muniak Paweł , Dolinska Barbara , Węgrzyn Rafał , Izydorczak Kamil 
Published: October 2021

AbstractUnrealistic optimism is the tendency to perceive oneself as safer than others in situations that equally threaten everybody. By reducing fear, this bias boosts one's well‐being; however, it is also a deterrent to one's health. Three experiments were run in a mixed‐design on 1831 participants to eliminate unrealistic optimism (measured by two items—probability of COVID‐19 infection for oneself and for others; within‐subjects) toward the probability of COVID‐19 infection via articles/videos. A between‐subject factor was created by manipulation. Ostensibly, daily newspaper articles describing other people diligently following medical recommendations (experiment 1) and videos showing people who did not follow these recommendations (experiment 2) reduced unrealistic optimism. The third experiment, which included both articles and videos, replicated these results. These results can be applied to strategies for written and video communications that can be used by governments and public health agencies as best practices concerning not only COVID‐19 but also any subsequent public health threat while promoting proactive, optimal, and healthy functioning of the individual.