bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of health professionals to feel traumatized during the COVID-19 pandemic
Authors: Braule Pinto André Luiz Carvalho , Serpa Alexandre Luiz Oliveira , de Paula Jonas Jardim , Costa Danielle Souza , Robis Kelly , Diaz Alexandre Paim , Joaquim Rui Mateus , da Silva Antônio Geraldo , de Miranda Débora Marques , Malloy-Diniz Leandro Fernandes 
Published: September 2021

AbstractHealth professionals may be a vulnerable group to posttraumatic stress symptoms (PTSS) during the Coronavirus disease 2019 (COVID-19) pandemic. To investigate how health professionals who experienced a traumatic event are expressing PTSS and factors related to risk for higher PTSS symptomatology can inform how health professionals are facing their role in this crisis. This was an Internet cross-sectional survey. Participants were 49,767 Brazilian health professionals who have ever faced a traumatic event, which was about 25.9% of an initial sample of health professionals. PTSS symptoms were assessed using the Impact of Event Scale-Revised (IES-R) and latent profile analysis (LPA) explored subpopulations within participants based on their scores. Distinct profiles were compared for psychological distress (e.g., depression and anxiety) and quality of life. Multinomial logistic regression analysis was conducted to investigate the relationship between IES-R profiles and COVID-19 related experiences, thoughts, and perceptions. A two-profile model was the most appropriate for the IES-R data pointing out a group with a high level of PTSS (named high-PTSS; n = 10,401, 20.9%) and another expressing a low level of symptoms (named low-PTSS; n = 39,366, 79.1%). The high-PTSS profile demonstrated worse psychological scores (global psychological distress, somatization, depression, and anxiety) and worse quality of life (physical, psychological, social, and environmental) with moderate magnitudes. Small but significant predictors of the high-PTSS profile included sociodemographic characteristics and COVID-19 related experiences, thoughts, and perceptions. Most individuals who experienced a traumatic event were not in the high-PTSS profile. For those who were, however, psychological and quality of life measures were much worse. During the initial phase of the COVID-19 pandemic, several characteristics emerged as risks to report trauma.
Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection
Authors: Hu Dingxue , Lu Yueqi , Wang Daoming , Nie Chao , Li Yan 
Published: September 2021

AbstractHelicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively homogenous strain of H. pylori. In this work, we performed SNP (single nucleotide polymorphism)-based, gene-based and pathway-based genome-wide association analyses to investigate the genetic basis of host susceptibility to H. pylori infection in 480 Chinese individuals. We also profiled the composition and function of the gut microbiota between H. pylori infection cases and controls. We found several genes and pathways associated with H. pylori infection (P < 0.05), replicated one previously reported SNP rs10004195 in TLR1 gene region (P = 0.02). We also found that glycosaminoglycan biosynthesis related pathway was associated with both onset and progression of H. pylori infection. In the gut microbiome association study, we identified 2 species, 3 genera and several pathways had differential abundance between H. pylori infected cases and controls. This paper is the first GWAS for H. pylori infection in Chinese population, and we combined the genetic and microbial data to comprehensively discuss the basis of host susceptibility to H. pylori infection.
The accuracy of gap and step-off measurements in acetabular fracture treatment
Authors: Meesters A. M. L. , ten Duis K. , Kraeima J. , Banierink H. , Stirler V. M. A. , Wouters P. C. R. , de Vries J. P. P. M. , Witjes M. J. H. , IJpma F. F. A. 
Published: September 2021

AbstractThe assessment of gaps and steps in acetabular fractures is challenging. Data from various imaging techniques to enable accurate quantification of acetabular fracture displacement are limited. The aim of this study was to assess the accuracy of pelvic radiographs, intraoperative fluoroscopy, and computed tomography (CT) in detecting gaps and step-offs in acetabular fractures. Sixty patients, surgically treated for acetabular fractures, were included. Five observers (5400 measurements) measured the gaps and step-offs on radiographs and CT scans. Intraoperative fluoroscopy images were reassessed for the presence of gaps and/or step-offs. Preoperatively, 25% of the gaps and 40% of the step-offs were undetected on radiographs compared to CT. Postoperatively, 52% of the gaps and 80% of the step-offs were missed on radiographs compared to CT. Radiograph analysis led to a significantly smaller gap and step-off compared to the CT measurements, an underestimation by a factor of two. Approximately 70% of the residual gaps and step-offs was not detected using intraoperative fluoroscopy. Gaps and step-offs that exceed the critical cut-off indicating worse prognosis often remained undetected on radiographs compared to CT scans. Less-experienced observers tend to overestimate gaps and step-offs compared to the more-experienced observers. In acetabular fracture treatment, gaps and step-offs were often undetected and underestimated on radiographs and intraoperative fluoroscopy in comparison with CT scans. This means that CT is superior to radiographs in detecting acetabular fracture displacement, which is clinically relevant for patient counselling regarding treatment decisions and prognosis.
Associations between increased circulating endothelial progenitor cell levels and anxiety/depressive severity, cognitive deficit and function disability among patients with major depressive disorder
Authors: Liou Ying-Jay , Chen Mu-Hong , Hsu Ju-Wei , Huang Kai-Lin , Huang Po-Hsun , Bai Ya-Mei 
Published: September 2021

AbstractThe association of major depressive disorder (MDD) with cardiovascular diseases (CVDs) through endothelial dysfunction is bidirectional. Circulating endothelial progenitor cells (cEPCs), essential for endothelial repair and function, are associated with risks of various CVDs. Here, the relationship of cEPC counts with MDD and the related clinical presentations were investigated in 50 patients with MDD and 46 healthy controls. In patients with MDD, a battery of clinical domains was analysed: depressed mood with Hamilton Depression Rating Scale (HAMD) and Montgomery–Åsberg Depression Rating Scale (MADRS), anxiety with Hamilton Anxiety Rating Scale (HAMA), cognitive dysfunction and deficit with Digit Symbol Substitution Test (DSST) and Perceived Deficits Questionnaire-Depression (PDQ-D), somatic symptoms with Depressive and Somatic Symptom Scale (DSSS), quality of life with 12-Item Short Form Health Survey (SF-12) and functional disability with Sheehan Disability Scale (SDS). Immature and mature cEPC counts were measured through flow cytometry. Increased mature and immature cEPC counts were significantly associated with higher anxiety after controlling the confounding effect of systolic blood pressure, and potentially associated with more severe depressive symptoms, worse cognitive performance and increased cognitive deficit, higher social disability, and worse mental health outcomes. Thus, cEPCs might have pleiotropic effects on MDD-associated symptoms and psychosocial outcomes.
Long-term evaluation of treatment protocols for isolated midfacial fractures in a German nation-wide craniomaxillofacial trauma center 2007–2017
Authors: Bonitz Lars , Wruck Vivienne , Peretti Elena , Abel Dietmar , Hassfeld Stefan , Bicsák Ákos 
Published: September 2021

AbstractAn update on the trends in maxillofacial traumatology provides additional information on the actual and changing needs. This retrospective study aimed to review all patient records of patients treated for isolated midface fractures in the Department of Cranial- and Maxillofacial Surgery at the Dortmund General Hospital between 2007 and 2017. The patient radiographs and patient files were reviewed. The safety and efficacy of the applied methods were controlled by assessing complications based on the Clavien-Dindo classification system. The statistical analysis included descriptive methods including regression analysis and χ2-test. In eleven years, 3474 isolated midface fracture sites have been identified in 2868 patients. The yearly trend is slightly increasing, in elderly clearly worsening, in children and youth decreasing. The male-to-female ratio was 2.16:1 for the whole study population, in the age group 18–25 y.o. 6.95:1 while in elderly above 80 y.o. 1:2.51, the age group specific incidence reflects this result, too. The most common fractures were nasal bone fractures (1405), zygomatic fractures (832) and orbital floor fractures (700). The average hospital stay was 2.7 days, the most fractures were operated within 24 h. The complication rate was 2.02% (Clavien-Dindo class II–V). The incidence of midfacial fractures is increasing in the total population and especially in elderly, but decreasing in children. Development of injury prevention measures is needed in this population. The diagnostic and therapeutic procedures are appropriate, as there is a low complication rate and short inpatient stay observed.
Early restrictive fluid balance is associated with lower hospital mortality independent of acute disease severity in critically ill patients on CRRT
Authors: Uusalo Panu , Hellman Tapio , Löyttyniemi Eliisa , Peltoniemi Julia , Järvisalo Mikko J. 
Published: September 2021

AbstractFluid overload (FO) with coincident acute kidney injury has been associated with increased mortality. However, it is unclear whether FO is an independent determinant of mortality for disease severity. We aimed to explore whether the development of fluid balance (FB) during the first 72 h of continuous renal replacement therapy (CRRT) is independently associated with hospital mortality. All patients admitted to a single centre ICU requiring CRRT for at least 24 h between years 2010–2019 were included. Extracted data included patient demographics and clinical parameters including daily cumulative fluid balance (FBcum), lactate, SOFA score and vasoactive requirement at the initiation and during the first 72 h of CRRT. 399 patients were included in the analysis. Hospital survivors had a significantly lower FBcum at CRRT initiation compared to non-survivors (median 1382 versus 3265 ml; p = 0.003). Hourly fluid balance per bodyweight (FBnet) was lower in survivors at 0–24, 24–48 and 48–72 h after initiation of CRRT (p < 0.008 for all comparisons). In the survival analysis (analyzed with counting process model) significant time-dependent explanatory variables for hospital mortality were FBnet (per ml/kg/h: HR: 1.319, 95% CI 1.038–1.677, p = 0.02), lactate (HR: 1.086, 95% CI 1.030–1.145, p = 0.002) and SOFA score (per ml/kg/h: HR: 1.084, 95% CI 1.025–1.146, p = 0.005) during the first 72 h of CRRT. Even after careful adjustment for repeated measures of disease severity, FBnet during the first 72 h of CRRT remains independently associated with hospital mortality, in critically ill patients with AKI.
Detection of clinically silent brain lesions in [18F]FDG PET/CT study in oncological patients: analysis of over 10,000 studies
Authors: Pietrzak Agata , Marszałek Andrzej , Kunikowska Jolanta , Piotrowski Tomasz , Medak Adrianna , Pietrasz Katarzyna , Wojtowicz Julia , Cholewiński Witold 
Published: September 2021

AbstractThe study aimed to show that including the brain region into the standard 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) study protocol may result in detecting clinically silent brain tumours. We retrospectively analyzed the group of 10,378 from the total of 12,011 consecutive patients who underwent the torso and brain [18F]FDG PET/CT scanning, considering an ability of the method to evaluate undetected before brain tumours in patients diagnosed and treated in our institution. While collecting the database, we followed the inclusion criteria: at least 1-year of follow-up, a full medical history collected in our institution, histopathologic examination or other studies available to confirm the type of observed lesion, and the most importantly—no brain lesions reported in the patients’ medical data. In this study, performing the torso and brain [18F]FDG PET/CT imaging helped to detect clinically silent primary and metastatic brain tumours in 129 patients, and the benign lesions in 24 studied cases, in whom no suspicious brain findings were reported prior to the examination. In conclusion, including the brain region into the standard [18F]FDG PET/CT protocol can be considered helpful in detecting clinically silent malignant and benign brain tumours.
HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
Authors: Fritzwanker Sebastian , Moulédous Lionel , Mollereau Catherine , Froment Carine , Burlet-Schiltz Odile , Effah Felix , Bailey Alexis , Spetea Mariana , Reinscheid Rainer K. , Schulz Stefan , Kliewer Andrea 
Published: September 2021

AbstractG protein-coupled receptors (GPCRs) are notoriously difficult to detect in native tissues. In an effort to resolve this problem, we have developed a novel mouse model by fusing the hemagglutinin (HA)-epitope tag sequence to the amino-terminus of the µ-opioid receptor (MOP). Although HA-MOP knock-in mice exhibit reduced receptor expression, we found that this approach allowed for highly efficient immunodetection of low abundant GPCR targets. We also show that the HA-tag facilitates both high-resolution imaging and immunoisolation of MOP. Mass spectrometry (MS) confirmed post-translational modifications, most notably agonist-selective phosphorylation of carboxyl-terminal serine and threonine residues. MS also unequivocally identified the carboxyl-terminal 387LENLEAETAPLP398 motif, which is part of the canonical MOP sequence. Unexpectedly, MS analysis of brain lysates failed to detect any of the 15 MOP isoforms that have been proposed to arise from alternative splicing of the MOP carboxyl-terminus. For quantitative analysis, we performed multiple successive rounds of immunodepletion using the well-characterized rabbit monoclonal antibody UMB-3 that selectively detects the 387LENLEAETAPLP398 motif. We found that >98% of HA-tagged MOP contain the UMB-3 epitope indicating that virtually all MOP expressed in the mouse brain exhibit the canonical amino acid sequence.
Perceived and mentally rotated contents are differentially represented in cortical depth of V1
Authors: Iamshchinina Polina , Kaiser Daniel , Yakupov Renat , Haenelt Daniel , Sciarra Alessandro , Mattern Hendrik , Luesebrink Falk , Duezel Emrah , Speck Oliver , Weiskopf Nikolaus , Cichy Radoslaw Martin 
Published: September 2021

AbstractPrimary visual cortex (V1) in humans is known to represent both veridically perceived external input and internally-generated contents underlying imagery and mental rotation. However, it is unknown how the brain keeps these contents separate thus avoiding a mixture of the perceived and the imagined which could lead to potentially detrimental consequences. Inspired by neuroanatomical studies showing that feedforward and feedback connections in V1 terminate in different cortical layers, we hypothesized that this anatomical compartmentalization underlies functional segregation of external and internally-generated visual contents, respectively. We used high-resolution layer-specific fMRI to test this hypothesis in a mental rotation task. We found that rotated contents were predominant at outer cortical depth bins (i.e. superficial and deep). At the same time perceived contents were represented stronger at the middle cortical bin. These results identify how through cortical depth compartmentalization V1 functionally segregates rather than confuses external from internally-generated visual contents. These results indicate that feedforward and feedback manifest in distinct subdivisions of the early visual cortex, thereby reflecting a general strategy for implementing multiple cognitive functions within a single brain region.
CCL01, a novel formulation composed of Cuscuta seeds and Lactobacillus paracasei NK112, enhances memory function via nerve growth factor-mediated neurogenesis
Authors: Ju In Gyoung , Hong Seong Min , Yun Soo-Won , Huh Eugene , Kim Dong-Hyun , Kim Sun Yeou , Oh Myung Sook 
Published: September 2021

CCL01, a novel formulation composed of Cuscuta seeds and Lactobacillus paracasei, enhanced memory function by inducing of the proliferation and differentiation of neural cells and formation of synapse via activation of neurotophin signaling pathway.
Role of Voice Therapy in Adherence to Voice Rest After Office-Based Vocal Fold Procedures
Authors: King Renee E. , Dailey Seth H. , Thibeault Susan L. 
Published: September 2021

Purpose
Patients undergoing vocal fold procedures significantly reduce but often do not cease voice use during absolute postprocedure voice rest. We hypothesized that patients who completed preprocedure voice therapy would increase adherence to postprocedure voice rest.

Method
Eighty-six participants completed this prospective cohort study. Patients scheduled for office-based vocal fold procedures, 1–3 days of absolute postprocedure voice rest, and preprocedure speech-language pathology (SLP) care were recruited. SLP care consisted of either (a) multiple voice therapy sessions, (b) one counseling/therapy session, or (c) voice evaluation only. Participants reported talking and other specific voice behaviors on 100-mm visual analog scales for up to 3 days pre- and postprocedure as well as changes in overall voice use at follow-up at least 1 week postprocedure.

Results
Talking decreased postprocedure by 63% in the therapy group and 65% in the counseling group, both significantly more than the 35% decrease measured in the evaluation group. There were group differences in talking at baseline but not during voice rest. Coughing and throat clearing were highest in the voice evaluation group and decreased less than talking during voice rest. At follow-up, 84% of participants reported that they completed voice rest for at least as long as recommended and 39.5% reported that they never used their voices during voice rest. Participants estimated a 98% overall reduction in voice use during voice rest at follow-up.

Conclusions
Voice use before and after vocal fold procedures varies by participation in preprocedure voice therapy. Patients significantly decrease talking during postprocedure voice rest but are not perfectly adherent. Communicative voice use decreases more than noncommunicative voice use during voice rest. Patients may overestimate adherence to voice rest at follow-up.

Supplemental Material

https://doi.org/10.23641/asha.16589864
A multi‐objective method for virtual machines allocation in cloud data centres using an improved grey wolf optimization algorithm
Authors: Hashemi Masoud , Javaheri Danial , Sabbagh Parisa , Arandian Behdad , Abnoosian Karlo 
Published: September 2021

AbstractCloud computing is a rapidly evolving computational technology. It is a distributed computational system that offers dynamically scaled computational resources, such as processing power, storage, and applications, delivered as a service through the Internet. Virtual machines (VMs) allocation is known as one of the most significant problems in cloud computing. It aims to find a suitable location for VMs on physical machines (PMs) to attain predefined aims. So, the main purpose is to reduce energy consumption and improve resource utilization. Because the VM allocation issue is NP‐hard, meta‐heuristic and heuristic methods are frequently utilized to address it. This paper presents an energy‐aware VM allocation method using the improved grey wolf optimization (IGWO) algorithm. Our key goals are to decrease both energy consumption and allocation time. The simulation outcomes from the MATLAB simulator approve the excellence of the algorithm compared to previous works.
Parallel‐in‐time‐and‐space electromagnetic transient simulation of multi‐terminal DC grids with device‐level switch modelling
Authors: Cheng Tianshi , Lin Ning , Liang Tian , Dinavahi Venkata 
Published: September 2021

AbstractThe electromagnetic transient (EMT) simulation of multi‐terminal DC (MTDC) grids requires a detailed device‐level modular multilevel converter (MMC) model, which can have thousands of state variables and complex internal structures. The fast device‐level insulated gate bipolar transistor (IGBT) transient requires a very small time‐step, making the computational overhead prohibitive. Based on the analysis of the parallel‐in‐time (PiT) implementation of detailed modelled MMCs, this paper proposes a task‐based hybrid PiT algorithm to achieve high parallel efficiency and speed‐up of MMC with device‐level modelling. Moreover, a transmission line model(TLM)‐based parallel‐in‐time‐and‐space (PiT+PiS) method is proposed to connect PiT grids to conventional or other PiT grids and exploit the maximum parallelism. Simulation results show greater than 30 speed‐up and 60% parallel efficiency on a 48 cores computer for the hybrid PiT method in a 201‐level three‐phase MMC test case, and 20 speed‐up in the transient simulation of CIGRÉ B4 DC grid test system for the PiT+PiS method.
Effects of clock deviations on the performance of microgrids based on virtual synchronous generators
Authors: Castilla Miguel , Miret Jaume , García de Vicuña Luis , Guzmán Ramón , Velasco Manel , Martí Pau 
Published: September 2021

AbstractAn inverter‐based microgrid is a small‐scale power network governed by a distributed control system. In this system, the nodes are the digital controllers of the power inverters, normally located at separate points within the microgrid. A relevant issue is that these controllers operate at different frequencies due to inherent clock deviations in the local hardware oscillators. This paper evaluates the effects of these clock deviations on the performance of microgrids equipped with inverters that emulate the operation of synchronous machines. A systematic procedure is presented to derive steady‐state expressions of the inverter active power and microgrid frequency as a function of clock drift rates. This procedure is applied to swing and governor equations of the virtual synchronous generators, revealing the mechanism that allows clock drifts to be absorbed, making their presence negligible. In addition, it allows recognising the controllers that should never be implemented in a distributed control system, since they cause an unsatisfactory behaviour that can even lead to a blackout in the microgrid. Therefore, the relevance of this study is the identification of the control schemes that are most sensitive to clock drifts, which makes it easier to choose the most suitable control implementation for a particular application. Furthermore, technical guidelines are reported to help researchers on developing control solutions more robust to clock drifts. In this study, the theoretical results are validated by experimental tests in a laboratory microgrid.