bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Vitamin D Supplementation on The Outcome of Treatment with Bevacizumab in Diabetic Macular Edema: A Randomized Clinical Trial
Authors: Fekri Sahba , Soheilian Masoud , Roozdar Sepehr , Abtahi Seyed-Hossein , Nouri Hosein 
Published: November 2021

Abstract
Purpose: Concomitant vitamin D deficiency (VDD) is speculated to aggravate diabetic macular edema (DME). We aimed to determine the effect of hypovitaminosis D correction on the outcome of treatment with intravitreal bevacizumab (IVB) in DME eyes.Methods: 83 eyes of 83 patients with DME were recruited and divided into three groups: normal vitamin D levels + IVB administration (Group 1 ), vitamin D insufficient/deficient + IVB administration (Group 2), and vitamin D insufficient/deficient + IVB administration+ oral vitamin D supplementation (Group 3). Visual (corrected distance visual acuity, CDVA) and anatomical (central macular thickness, CMT) outcomes of intervention were evaluated 1, 3, and 6 months after the triple IVB injections were completed. Serum vitamin D levels were measured 1 and 6 months after the third IVB administration. Results: In months 1, 3, and 6, after the basic triple IVB injection, visual acuity and CMT improved in all three groups, but improvements (both functional and anatomical) in groups 1 and 3 (sufficient vitamin D and corrected hypovitaminosis D) in month 6 were more significant than in group 2 (uncorrected hypovitaminosis D) (p <0.001). The mean number of IVB injections during follow-up was 5.33 (range: 4-7), which did not differ between the groups.Conclusion: Correction of vitamin D deficiency in DME patients with type 2 diabetes and vitamin D deficiency, in addition to IVB injections, may play a role in improving CDVA and CMT. However, this beneficial effect seems to be delayed by several months.Trial registration: Iranian Registry of Clinical Trials (IRCT), IRCT20200407046978N1, registered on April 11, 2020, - retrospectively registered. https://en.irct.ir/trial/46999
Laser Assisted Micro Grinding of Titanium
Authors: Sahu Ashish Kumar , Jha Sunil 
Published: November 2021

Abstract
Laser assisted micro-grinding (LAMG) is an emerging area of research in the field of high-quality micro-job fabrication and performance improvement. Conventional micro grinding (CMG) by micro pencil grinding tool suffers drawbacks such as tool deflection, higher cutting force and poor surface finish. In the present work, authors have attempted to investigate the performance of LAMG and CMG in the fabrication of micro-channel on Titanium material. Surface of workpiece was structured with the help of air assisted nanosecond-pulsed fiber laser scanning prior to the CMG at the different values of laser power by keeping scanning velocity constant. During the study, the CMG forces were recorded and after the processes surface roughness of the fabricated microchannels was measured. Results have shown reduction in the magnitude of the normal and tangential force by 31 % and 44 %, respectively, in LAMG compared to the CMG. In addition to that better surface finish was observed in LAMG than CMG. The surface roughness of micro-channel and grinding forces were found to be dependent on the power density of laser. Increase in the laser power deteriorates the surface finish and reduces the magnitude of grinding forces. High grinding forces in the CMG led to the dynamic deflection of the grinding wheel which produced the vibration in the process. The excessive vibration in CMG processes exploited the surface finish of the micro-channel. Such vibration was not observed on the LAMG process; as a result, better dimensional accuracy and surface finish of the channel was found.
Determination of temperature distribution on windings of oil transformer based on the laws of heat transfer
Authors: Grabko Volodymyr , Tkachenko Stanislav , Palaniuk Oleksandr 
Published: November 2021

Object of research: development of a technology for determining the temperature of the winding of a power oil transformer, in particular, the analysis of thermal processes in the winding of a power transformer during short-term overloads, taking into account the influence of the environment.
Investigated problem: temperature distribution in the winding of a power oil transformer taking into account short-term load surges in the problem of assessing the residual life of the insulation of the transformer winding by temperature aging. The calculation of the temperature distribution in the winding was carried out using the passport data and characteristics of the power oil transformer, including the winding, transformer oil, load currents.
Main scientific results: a mathematical model was calculated, with the help of which the results of temperature distribution in the transformer winding were obtained during short-term load surges or constant work with an increased load. According to the presented model, the analysis of the cooling time of the transformer winding after short-term overloads is carried out. Comparing the results obtained on the simulation model with the known results of experimental studies of the temperature distribution in the winding of a power transformer, the adequacy of the mathematical model is proved. It is shown that the use of the laws of heat transfer in a homogeneous plate to analyze the temperature distribution in the transformer winding is not wrong, but requires clarifications and simplifications.
The area of practical use of the research results: enterprises of the machine-building industry and energy companies specializing in the production and operation of transformer equipment. Innovative technological product: simulation model of heat distribution in a transformer winding, which can take into account the load of the transformer, the effect of the environment on the insulation of the transformer windings.
An innovative technological product: a method for diagnosing the duration of the non-failure operation of a transformer, which makes it possible to ensure trouble-free operation and save money for the repair of transformer equipment.
Scope of application of the innovative technological product: design and development of diagnostic systems for windings of power oil transformers
Determination of antimicrobial and fungicidal properties of experimental disinfectant "Sukhodez"
Authors: Fotina Tetiana , Slasten Dasha , Fotin Oleksii 
Published: November 2021

The results of the study of antimicrobial and fungicidal properties of the experimental preparation “Sukhodez” against microorganisms E. coli, Salmonella enteritidis, Staphylococcus aureus and fungi Candida albicans in the laboratory are presented.
The aim of the research. To study the antimicrobial and fungicidal properties of powdered disinfectant and analyze the prospects for its further use in a set of anti-epizootic measures in particular in poultry farms.
Materials and methods. The research was conducted during 2021 at the Department of Veterinary Examination, Microbiology, Zoohygiene and Safety and Quality of Animal Products of the Faculty of Veterinary Medicine of Sumy National Agrarian University. Evaluation of bactericidal properties of the experimental agent “Sukhodez” was determined on museum strains of E. coli ATCC 25922, Salmonella enteritidis ATCC 13076 and Staphylococcus aureus ATCC 6538, fungicidal properties were studied on fungi Candida albicans. All cultures were standardized to 109 CFU / cm3.
Results. It is established that as a result of the conducted researches at studying preparation “Sukhodez” antimicrobic properties, it had high efficiency concerning action on strains of both gram-positive and gram-negative bacteria. It had a detrimental effect on bacteria when applied to concrete at an exposure of 1 hour with a rate of 75 mg per 1 m2, and had the same effect as when applied to a wooden surface, where it expressed antimicrobial action at a rate of 50 mg/m2 after 4 hours. When determining the fungicidal properties, it was found that when exposed to 5 hours, the preparation “Sukhodez” had an effect on study contaminated objects with a rate of 50 mg/m2, and with a rate of 75 mg/m2 inhibited the growth of fungi for 1 hour.
Conclusions. It was found that the most sensitive to the preparation “Sukhodez” were the culture of Salmonella enteritidis – at a rate of 25 g / m2 and action on concrete and wooden surfaces, the disinfectant inhibited the growth of the culture when exposed to 5 hours, and at a rate of 50 g / m2 – for 2 years. Staphylococcus aureus was the most stable bacterial culture, so at a rate of 50 g / m2 on concrete and wood surfaces, bacterial growth was inhibited for 4 and 5 hours, respectively. At the same time, in the study of fungicidal properties, “Sukhodez” showed a fungicidal effect on Candida albicans when applied to a concrete surface at a rate of 50 mg / m2 for 3 hours, when applied to a wooden surface – for 4 hours.
In general, at a rate of 75 g / m2, “Sukhodez” has an instant bactericidal and fungicidal effect on bacteria and fungi applied to concrete and wooden surfaces
Biochemical status of blood of dogs with atopic dermatitis in the conditions of private veterinary clinic “Alfa vet” m. Konotop
Authors: Stotska Olga , Shkromada Oksana , Stockiy Aleksandr 
Published: November 2021

Metabolic changes in the body of dogs with atopic dermatitis and the causes of its occurrence still remain poorly understood. This study confirms the need for biochemical blood tests for the differential diagnosis of skin diseases in animals.
The aim of the research. To identify metabolic changes in dogs with atopic dermatitis.
Methods. Serum samples from five ill animals and five intact animals were tested. The diagnosis of the nosological form of skin lesions was established based on the results of anamnesis and clinical manifestations of the disease. Additionally, biochemical studies of the serum of sick animals were performed. Blood of dogs (n=5) was taken from the anterior subcutaneous vein of the forearm or the lateral subcutaneous vein of the tibia into blood tubes.
Results. In the study of mineral metabolism, it was found that the concentration of inorganic phosphorus in the serum of sick animals is reduced by only 0.01 mmol/l, but the concentration of total calcium by 10.0 %. The concentration of cholesterol increases 1.3 times and exceeds the reference values by 0.16 mmol/l. In the blood of sick animals, the activity of alanine aminotransferase is significantly reduced by 21.0 % and aspartate aminotransferase – by 20.0 % compared to intact animals. The enzyme gamma-glutamyltransferase probably increases by 1.51 times (P<0.05) in sick dogs, but does not exceed the reference values.
Conclusions. It was found that in atopic dermatitis in the serum of dogs decreases the activity of alanine aminotransferase by 21.0 % and aspartate aminotransferase – by 20.0 %, while the activity of gamma-glutamyltransferase increases 1.51 times. The results show the toxic effect of an allergic agent on animals, especially on the liver, which confirms the previous diagnosis – atopic dermatitis.
Application of bacillus megaterium for subclinical mastitis in cows
Authors: Tytukh Yaroslav , Musiienko Yurii , Grebenik Natalia 
Published: November 2021

The problem of treatment of subclinical mastitis often arises after calving, especially in cows of the first lactation. The paper presents the results of the therapeutic effect of Bacillus megaterium in subclinical mastitis in cows.
The aim of the research. To determine the effect of Bacillus megaterium on the microflora of the gastrointestinal tract and colonies of microorganisms isolated from subclinical mastitis in cows.
Materials and methods. The research was conducted in a dairy farm growing Holstein. Cows with subclinical mastitis of the experimental groups were given concentrated feed with the addition of Bacillus megaterium (1 × 109 CFU/g) at a dose of 15–35 g per animal. The control group of cows was given the usual diet for dairy cows. The experiment lasted 30 days.
Results. The use of Bacillus megaterium (1 × 109 CFU/g) at a dose of 35 g per animal had a pronounced effect on the microflora of the gastrointestinal tract of cows. The amount of Lactobacillus sp. was 67 % higher and Bifidobacterium 58 % higher than the control. In addition, the level of opportunistic pathogens on Escherichia coli decreased by 45 %, Clostridium by 27 %, Enterobacteriaceae and Staphylococcus by 75 %, and Candida by 80 % compared to controls. The amount of microflora in milk decreased by 40.2 % and the number of somatic cells by 87.9 %.
Conclusions. The therapeutic efficacy of Bacillus megaterium (1 × 109 CFU/g) at a dose of 35 g per animal for 30 days in subclinical mastitis has been proven. After treatment, the amount of microflora in cow's milk decreased by 40.2 % and the number of somatic cells by 87.9 %.
A positive effect on the microflora of the gastrointestinal tract of cows, where the number of Lactobacillus sp. increased by 67 % and Bifidobacterium by 58 %. The level of opportunistic pathogenic microflora decreased by Escherichia coli – by 45 %, Clostridium – by 27 %, Enterobacteriaceae and Staphylococcus – by 75 %, Candida – by 80 %, compared to the control.
Research progress on the contamination status and control policy of Giardia and Cryptosporidium in drinking water
Authors: Feng Cuimin , Xu Zhen , Li Ying , Zhu Na , Wang Zile 
Published: November 2021

Abstract
Cryptosporidium and Giardia are globally recognized protozoa that directly cause human diarrhea. Their transmission route mainly involves drinking contaminated water, thus needing proper water treatment to avoid human infection. At present, there is a lack of review on the infection status and control measures of the two protozoa. Hence, this article summarizes and compares the infection status and the role of drinking water in transmitting the Cryptosporidium and Giardia in some key countries in Asia, Africa, Europe, and the Americas. With collected data, this review offers recommendations for sanitary control and provides theoretical support for the application of drinking water treatment projects.
The Hybrid Compounds as Multi-target Ligands for the Treatment of
Alzheimer's Disease: Considerations on Donepezil
Authors: Gulcan Hayrettin Ozan , Kosar Muberra 
Published: November 2021

:
The strategies to combat Alzheimer’s Disease (AD) have been changing with respect to the
failures of many drug candidates assessed in clinical studies, the complex pathophysiology of AD,
and the limitations of the current drugs employed. So far, none of the targets, either validated or nonvalidated,
have been shown to be purely causative in the generation and development of AD. Considering
the progressive and the neurodegenerative characteristics of the disease, the main strategy has
been based on the design of molecules capable of showing activity on more than one receptor, and it
is defined as multi-target ligand design strategy. The hybrid molecule concept is an outcome of this
approach. Donepezil, as one of the currently employed drugs for AD therapy, has also been utilized in
hybrid drug design studies. This review has aimed to present the promising donepezil-like hybrid
molecules introduced in the recent period. Particularly, multi-target ligands with additional activities
concomitant to cholinesterase inhibition are preferred.
Neuropharmacological Activity of the New Piperazine Derivative 2-(4-((1-
Phenyl-1H-Pyrazol-4-yl)Methyl)Piperazin-1-yl)Ethyl Acetate is Modulated
by Serotonergic and GABAergic Pathways
Authors: Costa Elson Alves , Almeida Lorena de Souza , Santana Ianca Gontijo Cavalcante , da Silva Moreira Lorrane Kelle , Turones Larissa Córdova , Sanz Germán , Vaz Boniek G. , de Carvalho Flávio S. , Lião Luciano M. , Menegatti Ricardo , de Brito Adriane Ferreira 
Published: November 2021

Background:
Pharmacological treatments for mental disorders, such as anxiety and depression,
present several limitations and adverse effects. Therefore, new pharmacotherapy with
anxiolytic and antidepressant potential is necessary, and the study of compounds capable of interacting
with more than one pharmacological target may provide new therapeutic options.

Objectives:
In this study, we proposed the design, synthesis of a new compound, 2-(4-((1-
phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethyl acetate (LQFM192), pharmacological evaluation
of its anxiolytic-like and antidepressant-like activities, as well as the possible mechanisms of
action involved.

Methods:
Administration of LQFM192 was carried out prior to the exposure of male Swiss mice to
behavioral tests, such as the elevated plus-maze and forced swimming test. The involvement of the
serotonergic system was studied by pretreatment with WAY-100635 or p-chlorophenylalanine (PCPA)
and the involvement of the benzodiazepine site of the GABAA receptor by pretreatment with
flumazenil.

Results:
The treatment with LQFM192 at doses of 54 and 162 μmol/kg demonstrated anxiolyticlike
activity that was blocked by WAY-100635, PCPA, and flumazenil pretreatments. The potential
antidepressant-like activity was visualized at the same doses and blocked by WAY-100635 and
PCPA.

Conclusion:
In summary, the anxiolytic-like activity of LQFM192 is mediated by the serotonergic
system and the benzodiazepine site of the GABAA receptor, and the antidepressant-like activity
through the serotonergic system.
Microplastiche: classificazione, identificazione e rimozione all'interno degli impianti di trattamento delle acque reflue
Authors: Petrone Ciro Dario 
Published: November 2021

Negli ultimi decenni, l’interesse nel documentare le microplastiche
nell’ ambiente è notevolmente aumentato. La persistenza delle materie
plastiche nell’ambiente è il principale motivo per cui sono state
identificate come una grave minaccia. Il decadimento naturale degli
oggetti di plastica nell’ambiente richiede un tempo estremamente lungo,
inoltre queste micro particelle possono trasportare altri prodotti
chimici, usati come additivi nella loro fabbricazione, o assorbirli
attraverso la forte capacità di adsorbimento. Questo articolo si
prefissa di dare un contributo alle informazioni sul campionamento,
l’identificazione, l’analisi e la rimozione delle microplastiche ,
identificate come contaminanti emergenti, all’interno degli impianti di
trattamento delle acque reflue che sono considerati una fonte
importante per l’immissione delle microplastiche nei corpi idrici e nel
suolo.
Kecemasan terhadap Stigma Sosial untuk Kembali ke Masyarakat pada Mantan Narapidana Perempuan Tindak Pidana Penipuan
Authors: Putrie Kiki Adya , Putrie Kiki Adya 
Published: November 2021

Abstract: The aim of this study is to determine how the anxiety of social stigma returns to society in former female convict for a criminal act of fraud and the factors which influence that anxiety. Participant 1 is a 47 year old woman from South Jakarta and participant 2 is a 27 year old woman from Central Sulawesi. Participant 1 was imprisoned for 1 year 6 months (18 months) while participant 2 was imprisoned for 7 months (19 months). Both are former convicts of criminal acts of fraud cases. Researcher used data collection procedures using interview techniques. Interviews were conducted online due to the limitations of the current pandemic situation. The results of this study indicate that former female convicts of fraud have social stigma anxiety based on existing aspects. For further research, it is hoped that there will be more research on social stigma anxiety because it is interesting enough to be researched and is expected to be able to maximize the time. Keywords: Anxiety, Social Stigma, Former Female Convict
Pelatihan Regulasi Emosi Untuk Meningkatkan Subjective Well-Being Pada Penyandang Tunarungu di Kota Binjai
Authors: Mirza Rina , Lubis Afwan Faridh , Siagian Syah Fitriani , Simamora Sofi Septania , Sitohang Yolanda Jessica Elisabet , Claudia Cindy 
Published: November 2021

Abstract: The study aims to determine the influence of emotional regulatory training to improve subjective well-being. The subjects used in this study were deaf people in the city of Binjai and 10 people. The method used in this research is an experimental method with the model one group pretest-posttest. The hypothesis in this study states that there is a difference in subjective well-being in deaf people before and after emotional regulatory training. Subjective well-being in deaf people will increase after training is given. Data analysis result using paired samples t-test obtained the value of correlation (r) between before training and after training is 0.796 with significant 0.006 and t = -4.553 with a significant p = 0.001 < 0.05 which indicates that there is a difference between the subjective well-being before and after emotional regulation training which means the hypothesis is acceptable. The conclusion is that emotional regulation training gives an influence in improving the subjective well-being of deaf people in the city of Binjai. Indonesian Abstract. Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan pengaturan emosional untuk meningkatkan kesejahteraan subjektif. Subjek yang digunakan dalam penelitian ini adalah penyandang tuna rungu di Kota Binjai dan 10 orang. Metode yang digunakan dalam penelitian ini adalah metode eksperimen dengan model one group pretest-post test. Hipotesis dalam penelitian ini menyatakan bahwa terdapat perbedaan kesejahteraan subjektif pada penyandang tunarungu sebelum dan sesudah pelatihan pengaturan emosi. Kesejahteraan subjektif pada penyandang tunarungu akan meningkat setelah diberikan pelatihan. Hasil analisis data menggunakan uji-t berpasangan diperoleh nilai korelasi (r) antara sebelum pelatihan dan setelah pelatihan adalah 0,796 dengan signifikan 0,006 dan t = -4,553 dengan signifikan p = 0,001 <0,05 yang menunjukkan bahwa ada perbedaan antara subyektif. kesejahteraan sebelum dan sesudah pelatihan regulasi emosional yang berarti hipotesis dapat diterima. Kesimpulannya adalah bahwa pelatihan regulasi emosional memberikan pengaruh dalam peningkatan kesejahteraan subjektif pada penyandang tuna rungu di Kota Binjai.