bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automation of extra-analytical phase for clinical laboratory
Authors: Bakan Ebubekir , Umudum Fatma Zuhal 
Published: January 2021

Abstract
Extra-analytical automation is of critical importance in patient safety with respect to accurate, fast test result reporting. Through the previous decades, significant improvements in laboratory errors have been achieved by technological facilities, which have become a substantial part of the reduction of preventable diagnostic errors. In clinical laboratory practice, the total testing process (TTP) is under the effect of error sources: preanalytical, analytical, and post-analytical variables. Since many extra-analytical processes within and outside the clinical laboratory may be automated, management of the extra-analytical phase can prevent errors, resulting in the total quality of laboratory diagnostics and customer satisfaction. The automation technologies have added a serious impact on the proficiency of clinical laboratories. To improve standardization, organization, efficiency, and quality of TTP, many manual tasks have now been partially or entirely automated by labor-saving instrumentations. The implementation of extra-analytical automation in the laboratory processes has recently made them standardized and manageable. Depending on the workload and workflow of the clinical laboratory, it is of critical importance to implement adequate systems, providing standardization of the TTP and resulting in high-quality test results.
IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma
Authors: Yang Ying , Wang Jin , Xu Shihai , Lv Wen , Shi Fei , Shan Aijun 
Published: January 2021

Abstract

Background
In cancer, kappa B-interacting protein (IKBIP) has rarely been reported. This study aimed at investigating its expression pattern and biological function in brain glioma at the transcriptional level.

Methods
We selected 301 glioma patients with microarray data from CGGA database and 697 glioma patients with RNAseq data from TCGA database. Transcriptional data and clinical data of 998 samples were analyzed. Statistical analysis and figure generating were performed with R language.

Results
We found that IKBIP expression showed positive correlation with WHO grade of glioma. IKBIP was increased in isocitrate dehydrogenase (IDH) wild type and mesenchymal molecular subtype of glioma. Gene ontology analysis demonstrated that IKBIP was profoundly associated with extracellular matrix organization, cell–substrate adhesion and response to wounding in both pan-glioma and glioblastoma. Subsequent gene set enrichment analysis revealed that IKBIP was particularly correlated with epithelial-to-mesenchymal transition (EMT). To further elucidate the relationship between IKBIP and EMT, we performed gene set variation analysis to screen the EMT-related signaling pathways and found that IKBIP expression was significantly associated with PI3K/AKT, hypoxia and TGF-β pathway. Moreover, IKBIP expression was found to be synergistic with key biomarkers of EMT, especially with N-cadherin, vimentin, snail, slug and TWIST1. Finally, higher IKBIP indicated significantly shorter survival for glioma patients.

Conclusions

IKBIP was associated with more aggressive phenotypes of gliomas. Furthermore, IKBIP was significantly involved in EMT and could serve as an independent prognosticator in glioma.
Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway
Authors: Fu Kong , Chen Miancong , Zheng Hua , Li Chuanzi , Yang Fan , Niu Qian 
Published: January 2021

Abstract

Background
Morbidity and mortality remain high for ischemic stroke victims, and at present these patients lack effective neuroprotective agents, which improve the cure rate. In recent years, studies have shown that pelargonidin has many biological actions. However, few studies are available regarding the pelargonidin treatment of cerebral ischemia.

Methods
The rat middle cerebral artery occlusion (MCAO) model was established to investigate the neuroprotective effect of pelargonidin on cerebral ischemia/reperfusion injury. Reperfusion was performed 2 h after ischemia; magnetic resonance imaging (MRI) and 2, 3, 5-triphenyltetrazolium chloride (TTC) staining were used to measure the volume of cerebral ischemia. Both modified neurological severity scores (mNSSs) and Morris water maze test were used to assess the neurological functions. ELISA was applied to determine the levels of TNF-α, TGF-β, IL-6, IL-10, MDA, and SOD. The expression of Nuclear factor-E2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) protein in brain tissue was measured by immunofluorescence and Western blot assays.

Results
The results showed that pelargonidin could effectively reduce the volume of cerebral ischemia and improve the neurological function in MCAO rats, thereby improving memory and learning ability. With the corresponding decreases in the expression of TNF-α, TGF-β, IL-6, and MDA, the level of IL-10 and SOD increased and also promoted the nuclear metastasis of Nrf2 and the expression of HO-1 in ischemic brain tissues.

Conclusions
Our data demonstrated that pelargonidin ameliorated neurological function deficits in MCAO rats, and its potential mechanism of action was associated with overexpression of the Nrf2/HO-1-signaling pathway. This study will provide a new approach to treat cerebral ischemia/reperfusion injury.
Byzantine Monasticism on the Black Mountain West of Antioch in the 10th-11th Centuries
Authors: Glynias Joe 
Published: January 2021

This article sheds light on a hitherto unexplored phenomenon that alters our picture of Byzantine monasticism: the monastic culture of the Black Mountain outside Antioch. From 969-1084, the Black Mountain thrived as a destination for a variety of Chalcedonian monks: Greek-speaking Romans, Arabic-speaking Melkites, Georgians, and Armenians. I illustrate the prosperity of monastic life on the Black Mountain, the scholarly activity flourishing in and between languages, and the networks connecting the mountain to monasteries inside and outside of Byzantium.
In this paper, I examine three bodies of source material: manuscripts produced at the Black Mountain, texts produced by its scholars, and the letters of Nikon of the Black Mountain. Colophons in Greek, Arabic, Syriac, and Georgian manuscripts display the active scribal culture of these monasteries. Scholars centered at St. Symeon produced scores of translations from Greek into Arabic and Georgian that illustrate the lasting impact of this multilingual intellectual atmosphere. Nikon’s letters provide the basis for a cultural history of Antiochene monasticism. From these and other sources, I show that the Black Mountain was a major hub in middle Byzantine monastic networks. At the same time when Athos was assuming a primary role in the western Orthodox monastic world, the Black Mountain was performing a similar function in the east.
Itikad Baik Dalam Perjanjian Suatu Perspektif Hukum Dan Keadilan
Authors: Suprapti Endang , Tarigan Arihta Esther 
Published: January 2021

Contract or agreement is a first step in carrying out a fulfillment of needs and interests so humans are always in touch with each other in various places and times with various events.How good faith becomes the basis for parties to make an agreement. To answer this problem, research sources in the form of primary legal materials are needed, both in the form of laws and regulations, court decisions and secondary sources in the form of books, texts, legal dictionaries, legal journals. The research method in this paper uses primary and secondary legal materials, the law approach and conceptual approach. This type of research is normative and qualitative in nature.Keywords: Good faith, Agreement, Justice AbstrakKontrak atau perjanjian adalah suatu langkah awal dalam menyelenggarakan suatu pemenuhan kebutuhan dan kepentingan maka manusia selalu berhubungan satu sama lain di berbagai tempat dan waktu dengan berbagai macam peristiwa. Bagaimana itikad baik menjadi dasar bagi pihak dalam membuat suatu perjanjian. Untuk menjawab permasalahan ini diperlukan sumber penelitian berupa bahan hukum primer, baik berupa peraturan perundang-undangan, putusan pengadilan dan sumber sekunder berupa buku-buku, teks, kamus-kamus hukum, jurnal hukum. Metode penelitian dalam penulisan ini menggunakan bahan hukum primer dan sekunder, pendekatan undang-undang dan pendekatan konseptual. Jenis Penelitian ini adalah Normatif dan bersifat kualitatif.Kata Kunci: Itikad Baik, Perjanjian, Keadilan
Etika Bisnis Unit Usaha Pesantren (Studi Kasus Pondok Pesantren Sahid Bogor dan Pondok Pesantren Ummul Qura’ Al-Islami Bogor)
Authors: Cahyo Dwi Irfan 
Published: January 2021

AbstractEthics in Islamic business cannot be separated, because without it there will be confusion in determining the truth in doing business and there will be many crimes in business, thus the purpose of this study is to determine the application of business ethics in the pesantren business unit. The research methodology used is qualitative descriptive with a case study of the Sahid Bogor modern Islamic boarding school and also the Ummul Qura al-Islami Islamic boarding school in Bogor. The results of the study indicate that Islamic boarding school is able to apply business ethics through Islamic boarding school business unit as a place for Islamic teaching values and values as well as the principles of business ethics as materials that can be taught to teacher, student and the community around Islamic boarding school.Key words: Islamic business ethics, business units, Islamic boarding school AbstrakEtika dalam bisnis Islam tidak dapat terpisahkan, karena tanpanya akan menjadikan kerancuan dalam menentukan kebenaran dalam berbisnis serta akan terjadi banyak kejahatan dalam bisnis. Dengan begitu tujuan penelitian ini adalah untuk mengetahui penerapan etika bisnis pada unit usaha pesantren. Metodologi penelitian yang digunakan berupa kualitatif deskriptif dengan studi kasus pondok pesantren modern Sahid Bogor dan juga pondok pesantren Ummul Qura al-Islami Bogor. Hasil dari penelitian menunjukkan bahwa pesantren mampu menerapkan etika bisnis melalui unit usaha pesantren sebagai wadah dan nilai ajaran Islam serta prinsip etika bisnis sebagai bahan yang dapat diajarkan kepada asatidz dan santri serta masyarakat sekitar pesantren.Kata kunci: Etika bisnis Islam, Unit usaha, Pesantren
Az allogén vérképző őssejtátültetés korai szövődményei gyermekkorban
Authors: Horváth Orsolya , Nyirő Judit , Kállay Krisztián , Mező Blanka , Kassa Csaba , Hau Lídia , Kertész Gabriella , Horváth Máté , Sinkó János , Prohászka Zoltán , Kriván Gergely 
Published: January 2021

Absztrakt:
Bevezetés: Az allogén vérképző őssejt-transzplantáció (tx)
indikációja gyermekkorban a magas szövődményráta és a nem elhanyagolható
halálozás miatt csak az életet veszélyeztető betegségekre korlátozódik. A
csökkentett toxicitású kondícionáló kezelések bevezetése után célul tűztük ki az
egyes a transzplantációs szövődmények, mint graft-versus-host betegség (GVHD),
vírusreaktiváció és transzplantációhoz társult thromboticus microangiopathia
(TA-TMA) időbeli és egymáshoz viszonyított előfordulásának és a különböző
kondícionáló kezelések és a fenti transzplantációs szövődmények összefüggéseinek
feltárását. Betegek és módszer: Prospektíven száz (8,5 ± 4,9
év) gyermeket vizsgáltunk, akik malignus (n = 54) és nem
malignus alapbetegség (n = 46) miatt részesültek allogén
tx-ban. A kondícionáló kezelés megkezdésétől monitoroztuk a korai szövődmények,
így az akut GVHD, a vírusreaktivációk, a TA-TMA felléptét, illetve relapszus
jelentkezését. Eredmények: A gyerekek kétharmadánál (67%)
észleltünk legalább egy korai szövődményt a felsoroltak közül. A leggyakoribb
transzplantációs szövődmény a vírusreaktiváció volt (50%). Akut GVHD a betegek
26%-ánál, a medián 31. (10.–174.) napon alakult ki. Az akut GVHD-s esetek 27%-a
(7/26) zajlott súlyos (Grade III–IV) formában. A TA-TMA döntően enyhe volt,
kizárólag ciclosporin adása során, más transzplantációs szövődményekhez
társultan jelentkezett. A TA-TMA kialakulását 5/20 esetben GVHD, 5/20 esetben
vírusreaktiváció, és 4/20 esetben vírusreaktiváció és GVHD is megelőzte. A
súlyos szövődmények alacsony számával ellentétben a relapszusráta (22/54; 41%)
magas volt. A vizsgált betegcsoport összesített túlélése medián 3,8 (1,3–6,5) év
követési idő múltán 74%. A nem malignus betegség miatt transzplantált gyermekek
összesített túlélése kiváló (43/46; 93,5%). Ezzel szemben a malignus csoportban
a halálozási arány – a magas relapszusrátának megfelelően – (17/54, 31,5%)
magas. Következtetés: A csökkentett toxicitású kondícionáló
kezelések bevezetése óta a súlyos korai transzplantációs szövődmények száma
alacsony. A TA-TMA döntően enyhe formában, vírusreaktivációhoz vagy GVHD-hoz
társultan jelentkezett. A malignus alapbetegség esetén a halálozás fő oka a
relapszusok magas száma.
Riesgos psicológicos en adolescentes en situación de pobreza de un pueblo de la selva peruana
Authors: Vega Montoya Yndolina , Cjuno Julio 
Published: January 2021

El objetivo del presente trabajo es determinar las relaciones de las variables de riesgos psicológicos: satisfacción vital, autoestima, motivación de logro y expectativas de futuro de los adolescentes de un pueblo de la selva peruana que viven en pobreza. La metodología se basa en un estudio transversal, donde se dedujeron frecuencias relativas y absolutas, del mismo modo medidas de tendencia central y de dispersión, así también se analizó las relaciones de las variables a través del Chi cuadrado de Pearson con una confiabilidad del 95%. Los adolescentes involucrados en el estudio tuvieron una edad media de 14 años, la mayoría 69 (53.5%) fueron de sexo masculino y 37 (28.7%) sin escolaridad. Así también, 102 (79.1%) reportaron una satisfacción vital baja, 68 (52.7%) autoestima baja, 90 (69.8%) motivación de logro bajo y 86 (66.7) expectativas del futuro bajo. Se encontró relación significativa entre las variables sexo (p=,011) y satisfacción vital (p=,054) con expectativas del futuro. Así también, expectativas del futuro se relacionó con la satisfacción vital (p=,054) y la autoestima se relacionó con la motivación de logro (p=,004). Todas las variables de riesgos psicológicos reportan alta prevalencia del nivel bajo, el sexo y no tener escolaridad influyen 1de forma significativa, reforzado con la condición de pobreza en el que viven. Se requiere promover la atención de la salud psicológica de esta población a través de implementación del servicio de salud mental comunitaria en la selva peruana.
Ecosistema con creatividad, investigación e innovación basado en las competencias transversales frente a las exigencias profesionales del siglo XXI
Authors: Romero Carrión Violeta L. , García Flores Segundo A. , Palacios Sánchez José M. 
Published: January 2021

El objetivo de la investigación fue determinar si el Ecosistema con creatividad, investigación e innovación, basado en las competencias transversales, responde a las exigencias profesionales del siglo XXI. Para el estudio se aplicó el cuestionario de competencias transversales, del Proyecto Tuning, dirigido a 30 estudiantes universitarios, en cuyo caso se indagó sobre el logro en su formación, mientras que, en el caso de los 30 empleadores, fue conocer la importancia que le asignan a las competencias que deben poseer los nuevos profesionales. Luego de probar la normalidad de la distribución de los datos, se aplicó el estadístico de prueba de hipótesis T de Student para muestras independientes, obteniendo un valor altamente significativo, con respecto a que las competencias comprendidas en el Ecosistema con creatividad, investigación e innovación, son distintas, entre lo logrado por los estudiantes y lo exigido a los nuevos profesionales por los empleadores de las organizaciones del siglo XXI. Se recomienda disminuir la brecha entre las competencias transversales, logradas por los universitarios y las exigidas por los empleadores, mediante la actualización frecuente del currículo de estudio acorde a las demandas del mercado laboral.
Voluntariado en educación superior como base para el desarrollo profesional de los docentes
Authors: Vasileva Aitalina Nikolaevna , Koryakina Tatyana Grigoryevna , Nogovitscyna Nadezhda Mikhailovna , Nikiforova Tatyana Ivanovna , Adamova Liubov Konstantinovna 
Published: January 2021

El propósito de este trabajo es definir el papel de las actividades de voluntariado en el desarrollo profesional de los futuros docentes que actualmente son estudiantes de instituciones de educación superior. El principal método de investigación utilizado en este trabajo es descriptivo y cualitativo, ya que analiza un número de estudiantes voluntarios en el Instituto Pedagógico de la Universidad Federal del Nordeste de Ammosov (Sakha, Rusia) sobre la base de los resultados de la investigación sociológica anual de NEFU “Estudiante” para el período 2017-2019 y examinar su motivación por ser voluntario(a) a través de una encuesta. Los estudiantes se ofrecieron como voluntarios en una amplia gama de actividades: programas educativos, formación práctica académica, preparación de artículos científicos e implementación de proyectos socialmente significativos. Cuando los estudiantes universitarios de pedagogía organizaron sus actividades de voluntariado para relacionarlas con sus futuras actividades profesionales, ampliaron significativamente sus conocimientos sobre la profesión elegida, reforzaron su motivación para el desarrollo profesional y generaron adecuadas autoevaluaciones de sus cualidades personales y profesionales como futuros docentes. En conclusión: la actividad de voluntariado con orientación profesional como parte de la formación de futuros profesores desarrolla no solo las cualidades y competencias profesionales requeridas, sino que también se convierte en una etapa de su profesionalización, ayudándoles a encontrar su lugar de trabajo más rápidamente y desarrollando sus habilidades sociales y profesionales. Las implicaciones prácticas del estudio radican en la posibilidad de utilizar los resultados de la investigación para organizar actividades de voluntariado en las universidades.
Hafif dereceli obstrüktif uyku apne sendromlu olgularda D vitamini suplemantasyonunun antropometrik ölçümler ve vücut bileşimine etkisi
Authors: AYYILDIZ Feride , YILDIRAN Hilal , KÖKTÜRK Oğuz 
Published: January 2021

Amaç: Bu çalışma hafif dereceli obstrüktif uyku apne sendromu (OSAS) tanısı alan olgularda D vitamini suplemantasyonunun antropometik ölçümler ve vücut bileşimine etkisini incelemek amacıyla yapılmıştır.
Gereç ve Yöntem: Polisomnografi ile hafif dereceli OSAS tanısı alan ve D vitamini düzeyi yetersiz olan 20 yetişkin erkek (19-64 yıl) çalışmaya dahil edilmiştir. Olgulara sekiz hafta süresince 50.000 IU/hafta D3 vitamini suplemantasyonu verilmiştir. Çalışma başında ve sonunda tüm olguların bazı antropometrik ölçümleri (vücut ağırlığı, boy uzunluğu, bel, kalça ve boyun çevresi) alınmış ve vücut bileşimi analizleri yapılmıştır. Enerji ve besin ögesi alımları çalışma başında ve sonunda alınan 3 günlük bireysel besin tüketim kayıtları ile hesaplanmıştır.
Bulgular: Serum D vitamini düzeyi başlangıçta 19,1±5,16 ng/mL iken suplemantasyon sonrası 41,6±10,25 ng/mL’ye yükselmiş ve olguların %90’nın D vitamini düzeyi normal sınırlara ulaşmıştır. D vitamini suplemantasyonu sonunda olguların antropometrik ölçümleri ve vücut bileşimlerinde anlamlı fark olmamıştır. D vitamini suplemantasyonu sonunda diyet enerji, protein, yağ alımlarında ve apne hipopne indeksinde anlamlı azalma saptanmıştır.
Sonuç: Hafif dereceli obstrüktif uyku apne sendromu tanısı alan olgularda D vitamini suplemantasyonun enerji ve besin ögesi alımını etkileyebileceği görülmüştür. Ayrıca yetişkin olgularda D vitamini suplemantasyonunun hastalık prognozuna olumlu etkisinin olabileceği düşünülmektedir. Ancak D vitamininin vücut bileşimi ve antropometrik ölçümler üzerine etkisini incelemek amacıyla daha büyük örneklem ile uzunlamasına yapılacak çalışmalara ihtiyaç vardır.
Diyabetli bireylerde aile desteği ile yaşam kalitesi arasındaki ilişki
Authors: YILDIZ ASLAN Gamze , TEKİR Özlem , YILDIZ Hicran 
Published: January 2021

Amaç: Bu çalışmada diyabetli bireylerde aile desteği ile yaşam kalitesi arasındaki ilişkinin incelenmesi amaçlanmıştır.
Gereç ve Yöntem: Araştırmanın evrenini, Balıkesir Devlet Hastanesi Endokrinoloji Kliniği’nde tedavi gören bireyler; araştırmanın örneklemini ise araştırmaya dahil edilme kriterlerine uyan ve araştırmaya katılmaya gönüllü olan 260 diyabetli birey oluşturmuştur. Veri toplama formları olarak; Anket Formu, Hensarling’in Aile desteği ölçeği, Diyabete Özgü Yaşam Kalitesi Ölçeği kullanılmıştır.
Bulgular: Yaşam Kalitesinin alt boyutu olan aile durumu puanı ile Hensarling’in Diyabet Aile Destek Ölçeği toplam puanı ve alt boyut puanlarıyla arasında istatistiksel olarak anlamlı ilişki vardır. Aile durumu puanı arttıkça Hensarling’ in Diyabet Aile Destek Ölçeği toplam puanı da artmaktadır. Diğer alt boyut puanlar arasında istatistiksel olarak anlamlı ilişki bulunmamaktadır.
Sonuç: Diyabetli bireylerin Yaşam Kalitesi alt boyut puanı olan aile durumu puanı arttıkça Aile Desteği Ölçeği toplam puanı ve alt boyut puanları artmaktadır.
Evaluation of spontaneous gingival bleeding and related drug withdrawal frequency in atrial fibrillation patients using oral anticoagulants: a case-controlled study
Authors: ÖZCAN Mustafa , KOCA Hasan 
Published: January 2021

Purpose: The aim of this study was to investigate the frequency of gingival bleeding (GB) and associated drug-withdrawal in atrial fibrillation (AF) patients using oral anti-coagulants (OAC).
Materials and Methods: 457 patients with AF receiving OAC were screened. The periodontal parameters and OAC drug-withdrawal of 32 patients with spontaneous GB were compared with 32 patients without bleeding who were matched for age, sex and OAC treatment protocol.
Results: GB was detected in 32 patients (7.0%) and 13 of these patients (40.6%) had OAC drug-withdrawal due to bleeding. The plaque index (PI), gingival index (GI) and probing pocket depths (PPD) were significantly higher in patients with GB. The GI scores independently determined the risk of OAC drug-withdrawal.
Conclusion: AF patients under OAC treatment may have significant rates of GB and subsequent OAC withdrawal due to pre-existing periodontal disease. The GI scores and GB can predict the risk of OAC drug-withdrawal. The periodontal examination and/or treatment of these patients should be performed before OAC treatment.
Coronavirus
Authors: Rubio Nistal Pedro Miguel , Carvajal Urueña Ana María 
Published: January 2021

Las enfermedades causadas por coronavirus son conocidas y han sido estudiadas en veterinaria muchos años antes que en medicina humana por su importancia y por sus efectos en distintas especies de aves y de mamíferos. La primera vacunacontra una enfermedad por coronavirus en animales, la bronquitis infecciosa aviar, se desarrolló en 1950 mientras que el primer coronavirus humano se describióen 1965.En el presente trabajo se hace una revisión histórica de los aspectos que pueden ser más interesantes de las enfermedades causadas por coronavirus, aportando algunas experiencias propias con enfermedades causadas por coronavirus en el cerdo, algunas de ellas emergentes e ilustrativas de lo que son estas enfermedades.Se resaltan las características epidemiológicas de las zoonosis causadas por coronavirus, su origen y el carácter preocupantemente emergente de las mismas enmedicina humana; es por esto que el conocimiento de los antecedentes de la pandemia actual causada por SARS-CoV-2 resultan muy elocuentes a la hora de interpretar la actual emergencia sanitaria, que aunque sorpresiva no resulta unhecho inesperado. What do you want to do ?New mailCopy What do you want to do ?New mailCopy