bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Nutritional Deficiency-5 Years and More Outcomes Post Laparoscopic Sleeve Gastrectomy
Authors: Çırak Elif , Sancak Seda , Özdemir Ali , Karip Aziz Bora , çeler özgen , Okuroğlu Nalan , Fersahoğlu M. Mahir , Aydın M. Timuçin , Bulut Nuriye Esen , Altun Hasan , Çiğiltepe Hüseyin , Memişoğlu Kemal 
Published: September 2021

Abstract
IntroductionNowadays one of the most popular surgical method for treatment of obesity is laparoscopic sleeve gastrectomy (LSG). Data regarding long-term nutritional deficiencies following LSG are scare. We aim to assess the prevalence of nutritional deficiencies 5 years post-LSG.MethodsWe retrospectively reviewed the files of 338 patients who had LSG surgery between June 2012 and June 2019 and had preoperative data and had at least 1 year of surgery. Serum iron, ferritin, folic acid, hemoglobin and vitamin B12 levels during annual visits for six years after LSG were compared with preoperative data. Patients with missing data during follow-up were evaluated as dropout and assessments were made on patients with available data.ResultsA total of 338 patients (83% women), with a baseline BMI 46,87±6,17 kg/m2 were included. In baseline, hypoferritinemia was detected in 19.16% for <15 ng/mL cutoff and in 43.11% for <30 ng/ml cutoff value. Serum iron, vitamin B12 and folate deficiencies were exist in 37.62%, 18.64% and 4.14% of the patients, respectively. We compared this prevalances with postoperative datas and found that ferritin deficiency in follow-up visits was significantly more frequent than the baseline (p<0.001), conversely vitamin B12 deficiency was significantly less common (p<0,05).ConclusionDespite the supplement, our results show that the prevalence of patients with hypoferritinemia after LSG is higher than before surgery. This high prevalence may be associated with factors such as insufficient supplementation, insufficient absorption of oral preparations, and insufficient compliance to treatment.
Study on the Effect of Income Perception on Cleaner-Production Fraud
Authors: Liu Ming , li yemei 
Published: September 2021

Abstract
We investigate a single-cycle product supply chain with one retailer and one supplier in a game model, where the supplier is the leader and the retailer is the follower. By innovatively introducing cleaner production fraudulent income perception factor into the game model, we studied the mechanism of the effect of enterprise social responsibility and environmental awareness on cleaner production fraud. The results showed that the value of cleaner production fraudulent income perception factor will affect the enterprise's choice of differentiation strategy. When the enterprise's sense of social responsibility is weak, i.e., the fraudulent income perception factor is correspondingly large, it more likely to choose cleaner production fraud. Conversely, under the constraints of high social responsibility, it more likely avoids production fraud. Regarding government supervision, a reasonable punishment for cleaner production fraud can reduce such violations to some extent. However, after the punishment reaches a level, the efficiency of supervision beginning to decline. In views of that, improving enterprise social responsibility through institutional reform is a more effective way to reduce cleaner production fraud. To contribute to a healthy competitive market environment, government supervision should establish a feedback mechanism, and make timely adjustments.
Association Between Methylation Levels of LPL, ADRB3 and MTHFR Genes in Leukocytes from Individuals with Isolated or Associated Morbidities and Inflammation: A Cross-Sectional Study
Authors: Matte Thais Costa , Lima Raquel Patrícia Ataíde , Luna Rafaella Cristhine Pordeus , Gonçalves Maria da Conceição Rodrigues , Ferreira Flávia Emília Leite de Lima , Diniz Sônia Cristina Pereira de Oliveira Ramalho , de Lima Roberto Teixeira , de Almeida Aléssio Tony Cavalcanti , Silva Alexandre Sérgio , Diniz Alcides da Silva , de Oliveira Naila Francis Paulo , Persuhn Darlene Camati , Costa Maria José de Carvalho 
Published: September 2021

Abstract
Epigenetic alterations such as DNA methylation have been associated with the etiology of inflammation-related diseases. The present study evaluated the association between the methylation levels of LPL , ADRB3 and MTHFR genes and the stage of inflammation in individuals with isolated or associated morbidities, as well as in individuals without morbidities. This is a cross-sectional population-based study, in which 261 adults, between 20 and 59 years, individuals of both sex were selected. Inflammatory parameters were evaluated in blood, and the evaluation of methylation levels in the promoter of LPL , ADRB3 and MTHFR genes was performed in peripheral blood leukocytes. For statistical treatment, normality analysis was performed using the Lilliefors test, multiple linear regression, in addition to odds ratio. For all tests, the significance level adopted was 5%. In individuals with isolated morbidities, a positive association was observed between CRP values ​​(2.49mg/L±3.7) and LPL gene methylation levels (35%±18) (p=.003) and with associated morbidities, females had higher levels of LPL gene methylation (40% ± 20) (p = 0.041) and for MTHFR gene methylation levels (35% ± 18) a positive association was found with MDA values ​​(3.02µmol/L± 0.8) (p=.032). In addition, the use of medications did not influence the level of methylation for any of the three genes analyzed. Among individuals with isolated or associated morbidities, there was an association between the methylation levels of the LPL gene with the CRP values ​​and females, and furthermore with the MTHFR gene and MDA. This study could help to understand the etiology and treatment of different morbidities, enabling the discovery of new combats resources.
High Temperature Increased Lignin Contents of Poplar (Populus spp) Stem via Inducing the Synthesis Caffeate and Coniferaldehyde
Authors: Zhao Xianyan , Li Panpan , Liu Xingwang , Xu Tianyu , Zhang Yuqing , Meng Haifeng , Xia Tao 
Published: September 2021

Abstract
Background

Lignin contributes to plant resistance to biotic and abiotic stresses and is dominantly regulated by enzymes which catalyze the generation of metabolites intermediates in lignin synthesis. However, the response of lignin and its key regulatory factors to high temperature stress are poorly unknown.
Results

Here, this finding revealed that the content of lignin in poplar (Populus spp) stem increased after three days of high temperature stress treatment. In fourteen metabolic intermediates of lignin biosynthetic pathway with targeted metabolomics analysis, caffeate and coniferaldehyde increased evidently upon heat stress. C3’H (p-Coumaroylshikimate 3-hydroxylase) and CCR (Cinnamoyl-CoA reductase) are recognized to catalyze the formation of caffeate and coniferaldehyde, respectively. Transcriptome data and RT-qPCR (reverse transcription-quantitative real-time polymerase chain reaction) analysis found the high transcriptional level of PtrMYBs (PtrMYB021, PtrMYB074, PtrMYB85, PtrMYB46), PtrC3’H1 (Potri.006G033300) and PtrCCR2 (Potri.003G181400), suggesting that they played the vital role in the increase of lignin and its metabolic intermediates induced by high temperature.
Conclusions

The discovery of key regulators and metabolic intermediates in lignin pathway that respond to high temperature provides a theoretical basis for quality improvement of lignin and the application of forest resources.
Prevalence of Wasting and its Associated Factors among Children age from 6-59 Months in Debre Tabor Town Amhara Region of Ethiopia 2019: A Multi-center Community-based Cross-sectional Study
Authors: Getu Bisrat Dessie , Tibebu Nigusie Selomon , Azanaw Kefyalew Amogne , Zimamu Libsuye Yalgaw , Adal Gashaw Mekete , Emiru Tigabu Dessie , Atalell Kendalem Asmare 
Published: September 2021

Abstract
Introduction: Wasting is acute malnutrition that has harmful short-term consequences for children and it is determined by inadequate diet. Therefore, this study was aimed to assess the prevalence and associated factors of wasting among children age 6-59 months at Debre Tabor town Ethiopia, 2019.Method: A community-based cross-sectional study was conducted on wasting using simple and systematic random sampling. A sample of 436participants completed a questionnaire designed for the study. The questionnaire was coded and entered into Epi info version 7.2.0.1 and exported to SPSS 20.0 for data analysis. Principal component analysis (PCA) was used to compute family wealth status. Bivariable and multivariable logistic regression analyses were done to see which independent variables have an association with the dependent variable, and a P value of less than 0.05 was considered as significant at 95% CI.Results: The result revealed that wasting for children age 6-59 months was 6.2 %( 95% CI 3.9%-8.5 %,). Children with the age group of 6-11 months were 4.3 times more likely to have wasted than those age group of 24-59 months [AOR: 4.3; 95% CI: 1.5–12.5]. Similarly, parents who have poor wealth status in their family are 3.1 times more likely to have wasted children than those who have rich wealth status in their family [AOR: 3.1 (1.01–9.35)]. Mothers who gave first birth at the age group of 20-25 years of age were 4.3 times more likely to have wasted children than those who gave birth at an age group of greater than 30 years [AOR: (4.3(1.56-12.5)].Conclusion: Undernutrition especially wasting is still an important public health problem in children with an age group of 6-59 months. Age of the child, wealth status of the family, and giving the first birth before 20 years of age were significantly associated with wasting. Therefore, family wealth status should be modified, create awareness to the mothers regarding maternal and child health care and responsible bodies should be designed for further nutritional intervention programs.
Triangular Policy Inference from Renewable Energy, Foreign Direct Investment (FDI) and Urbanization Towards Climate Goal: Insight from Indonesia
Authors: Udemba Edmund Ntom , Philip Lucy Davou 
Published: September 2021

Abstract
This is an expository study towards ascertaining the ability of Indonesia in mitigating carbon emission. Indonesia is positioned as among the best performing economies in Southeast Asia because of its vigorous fiscal management and sustained economic growth over the years. The country’s foreign investment inflow increased to 14% in 2019, largely in gas, electricity, water, and transportation because of the viability of its macroeconomic reforms. To test the environmental implication of this macroeconomic performance of Indonesia and to see its ability to achieve carbon neutrality, we adopt Indonesian quarterly data of 1990Q1- 2018Q4 for empirical analysis. Relevance Instruments in the economic performance of Indonesia such as urbanization, foreign direct investment (FDI) and renewable energy source are all adopted for accurate estimations and analysis of this topic. Different approaches such as structural break test, autoregressive distributed lag (ARDL)-bounds testing and granger causality are all adopted in this study. Our analysis and policy recommendations are based on short run and long run ARDL dynamics and granger causality. Findings from ARDL confirmed, negative relationship between carbon emission and renewable energy source, FDI and urbanization. Also, a U-shape instead of inverted U-shape EKC is found confirming the impeding implication of Indonesian economic growth to its environmental performance if not checkmate. From granger causality analysis, all the variables are seen transmitting to urbanization in a one-way causal relationship. Also, FDI and renewable energy prove to be essential determinants of the country’s environment development, hence, FDI is seen transmitting to both energy source (fossil fuels and renewables) in a one- way causal relationship. Renewable energy is as well seen having two ways causal relationship with both carbon emission and fossil fuels. This result has equally exposed the significant position of the three instruments (urbanization, FDI and renewable energy source) in Indonesia environment development.
Analysis of Risk Factors of Multiorgan Failure After Pericardiectomy For Constrictive Pericarditis
Authors: Huang Jing-bin , Wen Zhao-ke , Yang Jian-rong , Li Jun-jun , Li Min , Lu Chang-chao , Liang Da-ying , Wei Cheng-xin 
Published: September 2021

Abstract
Background: We aimed to investigate risk factors of multiorgan failure following pericardiectomy.Methods: This was a retrospective study of patients undergoing pericardiectomy between January 1994 and May 2021 at three hospitals.Results: 826 patients were included in the study and divided into two groups: group with multiorgan failure (n=86) and group without multiorgan failure (n=740). There were 86 patients with multiorgan failure (86/826, 10.4%). There were 66 operative deaths (66/826, 8.0%). The causes of operative deaths were multiorgan failure (86/826, 10.4%), including cardiogenic shock + AKI + ventricular fibrillation (15/86), cardiogenic shock + AKI (46/86), cardiogenic shock + AKI + hepatic failure + septicemia (10/86), cardiogenic shock + AKI + respiratory failure (15/86). Univariate and multivariate analyses showed the factors associated with multiorgan failure, including male (P=0.006), time between symptoms and surgery (P＜0.001), thickness of pericardium (P＜0.001), intubation time (P＜0.001), ICU retention time (P＜0.001), hospitalized time postoperative (P＜0.001), preoperative central venous pressure (P＜0.001), postoperative central venous pressure (P＜0.001), D0 fluid balance (P＜0.001), D2 fluid balance (P＜0.001), postoperative chest drainage (P＜0.001), preoperative LVEDD(P＜0.001), postoperative LVEDD (P＜0.001), surgical duration (P＜0.001), bleeding during operation (P＜0.001), serum creatinine 24h after surgery (P=0.042), serum creatinine 48h after surgery (P＜0.001), fresh-frozen plasma (P＜0.001), packed red cells (P＜0.001), blood lactate (P＜0.001).Conclusion: In our study, incomplete pericardial dissection, fluid overload, delayed diagnosis and treatment are associated with multiorgan failure following pericardiectomy.
Circulating Exosomal hsa_circRNA_0039480 is Highly Expressed in Gestational Diabetes Mellitus and May Be Served As A Biomarker for Early Diagnosis of GDM
Authors: Jiang Bao , Zhang Junfeng , Sun Xiubin , Yang Chunyan , Cheng Guanghui , Xu Mengru , Li Siyuan , Wang Lina 
Published: September 2021

Abstract
Background: Gestational diabetes mellitus (GDM) seriously affects the health of mothers and babies, and there are still no effective early diagnostic markers. Therefore, it is necessary to find diagnostic biomarkers for screening GDM in early pregnancy. Circular RNA (circRNA) is more stable than linear RNA, and can be encapsulated in exosomes and participate in the pathological process of various diseases, which makes it a better candidate biomarker for various diseases. In this study, we attempted to identify the exosomal circRNA biomarkers for detecting early GDM.Methods: We performed microarray analysis to compare the plasma exosomal circRNA expression profiles of three GDM patients 48 hours before and 48 hours after delivery. The repeatability of the expression of circRNAs were randomly validated by RT-PCR analysis. Pearson correlation analysis was applied to evaluate the correlation between circRNAs and circRNA-OGTT level. ROC curve was established to assess the diagnostic value of circRNAs for GDM at different stages.Results: Plasma exosomal hsa_circRNA_0039480 and hsa_circRNA_0026497 were highly expressed in GDM patients before delivery(P<0.05). The hsa_circRNA_0039480 expression was higher for GDM group than NGT group at different stages, and was also positively correlated with OGTT during the second trimester (P<0.05). The expression of hsa_circRNA_0026497 was higher for GDM group during the third, and second trimesters. And there was a strong correlation between two circRNAs in GDM patients during the first-trimester (r =0.496, P=0.014). Hsa_circRNA_0039480 showed significant diagnostic value in the first, second, and third trimesters of pregnancy (AUC = 0.704, P=0.005; AUC = 0.898, P < 0.001 and AUC = 0.698, P= 0.001, respectively). Notably, the combination of hsa_circRNA_0039480 and hsa_circRNA_0026497 exhibited promising discriminative effect on GDM in the first trimesters (AUC=0.754, P < 0.001).Conclusion: Plasma exosomal hsa_cirRNA_0039480 is highly expressed in GDM patients and may be served as a candidate biomarker for early detection of GDM.
Flexible Endoscopic Treatment of Esophageal Diverticulum: A Case Report
Authors: Zhang Quan , Zhu Sumin 
Published: September 2021

Abstract
BackgroundIn the past, surgical resection was the only treatment available for esophageal diverticulum. Minimally invasive endoscopic treatment of esophageal diverticulum has become more and more popular in recent years. We reported a case of transoral endoscopic resection of esophageal diverticulum and crestectomy, which had a similar effect to surgery and retained the physiological function of the esophagus. It has the advantages of short procedure time, short hospital stay, and good long-term prognosis.Case presentationA 67-year-old gentleman presented with persistent dysphagia and repeated nausea and vomiting for 2 years. Combined with chest CT, barium esophagography and esophagogastroduodenoscopy, the diagnosis was a mid-esophageal diverticulum. After discussion and communication, the patient underwent oral endoscopic esophageal diverticulectomy. During the operation, the weak area of the bottom muscle layer of the diverticulum was completely removed, and the crest of the diverticulum was cut off, and the kiss suture was performed with titanium clips to reduce tension. After the operation, the right pleural effusion occurred and the lung infection was aggravated, and the right pleural drainage tube was placed to relieve the symptoms. An 18*100mm fully covered metal stent was placed under a gastroscope. Place the duodenal nutrition tube and the gastric tube drainage tube for vacuum suction. After a long period of fasting, enteral nutrition support, adequate postoperative drainage treatment and antibiotic treatment eventually l resulted in full recovery without recurrence.ConclusionThe selection of treatment for esophageal diverticulum needs to refer to many factors. For the middle esophageal diverticulum, especially those with large diverticulum sac and small mouth, and those who have indications for surgery, in addition to selective surgery and conventional endoscopic surgery, you can also try endoscopic diverticulectomy and crestectomy.
Movement Quality Parameters During Gait Assessed by a Single Accelerometer in Subjects with Osteoarthritis and Following Total Joint Arthroplasty
Authors: Emmerzaal Jill , Corten Kristoff , Straaten Rob van der , De Baets Liesbet , Rossom Sam Van , Timmermans Annick , Jonkers Ilse , Vanwanseele Benedicte 
Published: September 2021

Abstract
Background: This study aimed to evaluate which of movement quality parameters measured with a single trunk worn Inertial Measurement Unit (IMU) can distinguish the gait pattern of people with hip or knee osteoarthritis (OA) compared to asymptomatic controls. Secondly, we evaluated the sensitivity of these parameters to capture gait changes at 6 weeks, 3, 6, and 12 months following total knee arthroplasty (TKA). Thirdly, we investigated whether observed changes in movement quality from 6 weeks and 12 months following total knee arthroplasty were related to changes in patient-reported outcome measures.Methods: Twenty people with hip OA, 18 people with knee OA, and 20 asymptomatic controls participated in this study. Seventeen people with knee OA were treated with a TKA and additionally followed for one year postoperatively. The participants were equipped with a single trunk-worn IMU and were instructed to walk back and forth along a 10m walkway at a self-selected speed. The movement quality parameters (quantified by symmetry—step/stride regularity; complexity—Sample entropy; smoothness—Log Dimensionless Jerk; and dynamic stability—maximum Lyapunov Exponent) were calculated from the raw 3D acceleration signal. Comparisons were made between groups and between timepoints in the TKA patients. Finally, changes in movement quality were correlated with patient-reported outcomes in the TKA group.Results: We found significant group differences in movement symmetry and stability pre-operatively. Post-TKA, all parameters, except movement smoothness, reflected an initial decrease in movement quality at 6 weeks post-TKA, but all except movement complexity, normalised after 6 months. Moreover, improved movement quality (6 weeks-12 months post-TKA) related to improvements in patient-reported outcome measures.Conclusions: A single lower back IMU can characterise movement quality before and after a total joint arthroplasty. Most symmetry measures recovered but a more unstable, less complex gait pattern was observed at follow-up. The correlation between these parameters and patient-reported outcome measures shows the potential to monitor movement quality in a clinical setting to inform objective data driven personalised rehabilitation of quantified gait symmetry, stability, complexity, and smoothness.
The Regulatory Effects of The Combined Dietary Supplementation of Essential Oils And Organic Acids On The Microbial Communities of Cobb Broilers.
Authors: Qiao Jiayun , Shang Zhiyuan , Liu Xuejiao , Wang Kewei , Wu Zhiwei , Wei Qing , Li Haihua 
Published: September 2021

Abstract
Background: The emergence and spread of antibiotic resistance genes in pathogenic microorganisms have led to many countries enacting restricted use of antibiotics as growth promoters in animal feed. The combined use of essential oils and organic acids can help maintain intestinal health, improve animal growth performance, and alleviate the negative effects of banned antibiotics for certain economically important animals. However, the modes of action for the combined dietary supplementation of essential oils and organic acids (thymol-citric acid; EOA1, and thymol-butyric acid; EOA2) remain unclear, although it is speculated that their activities are achieved through beneficial modulation of gastrointestinal microbial communities and the inhibition of pathogen growth. In this study, 16S rDNA amplicon sequencing was used to analyze the effects of treatment with EOA1 and EOA2 on the jejunal, cecal, and fecal microbial communities of Cobb broilers (using enramycin and virginiamycin as positive controls) while also evaluating effects over different broiler ages (14, 28, 35, and 42 days old). Results: We found that the intestinal microbial communities of the broilers developed with increasing age, while Lactobacillus gradually came to dominate intestinal communities. Further, the microbial communities of feces were more complex than in the jejuna and ceca. The longitudinal changes in these communities were systematically explored for broilers of different ages. The addition of EOA1 or EOA2 to the diet: 1) inhibited the proliferation of Ralstonia pickettii and Alcaligenaceae in jejuna on the 28th day, 2) promoted the colonization and growth of beneficial bacteria like Lactobacillus, Clostridia, and Bacteroidia at various growth stages, and 3) enriched the abundances of certain microbiota functions including biological pathways related to metabolism (e.g., enzyme families).Conclusions: EOA1 and EOA2 dietary supplementation can affect various microbial metabolic pathways related to the metabolism and absorption of nutrients via the regulation of intestinal microbial community structures of Cobb broilers, while also playing an important role in promoting host growth.