bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embryonic and larval development of the caridean shrimp Palaemon argentinus (Decapoda, Caridea): effects of salinity and diet
Authors: Tropea Carolina , Stumpf Liane , López Greco Laura S. 
Published: January 2021

Abstract
The caridean shrimp Palaemon argentinus is a species of commercial and ecological interest. Its numerous larval stages, the lack of knowledge on their nutritional requirements, and their ability to survive in a wide range of salinities raise questions on the optimum conditions for larval rearing in captivity. The present study was aimed at evaluating embryonic development under different salinities and larval development under different combinations of salinities and diet regimes, in order to define alternative, cheaper culture conditions. We tested salinities usually encountered by the species in natural habitats (0.1, 1 and 5 ppt) and a highly protein-inert diet (Tetracolor®) as a potential replacement for live food (nauplii of Artemia salina). The incubation period and fecundity were similar among salinity treatments. Overall, the number of survival days and percentage of zoeae that moulted two, three and four times were higher when embryogenesis occurred at 5 ppt and when larvae were exposed to 5 ppt. These results suggest that the conditions experienced by embryos affect the performance of the first larval stages, and probably reflect the lower energetic requirements of zoeae to osmoregulate as water and haemolymph osmolarity become closer. On the other hand, larval performance was better when fed A. salina nauplii than Tetracolor®. The latter may not cover the nutritional requirements of zoeae or may have low digestibility due to insufficient enzymes in the undeveloped larval digestive system. Based on the present results, we conclude that a salinity of 5 ppt combined with a diet consisting of Artemia sp. nauplii is optimal for larval culture at early stages.
Digital Waistlands: Pro-Ana Communities, Religion, and Embodiment
Authors: Rifai Emma 
Published: January 2021

Abstract
Pro-ana is an online community that shares resources that support the progression and maintenance of eating disorders. It simultaneously offers participants anonymity and visibility in virtual space as well as the chance to develop social connections with other like-minded individuals who support, rather than censure, their “deviant” behaviors. This paper attends to the intersection of religion, embodiment, and digital culture in the pro-ana movement by exploring how anas embody religious values through their performances of pro-ana culture. We see this both in terms of the more obvious mobilizations of religious rhetorics common with some of the pro-ana community, as well as in more subtle manifestations of Protestant values embedded in key pro-ana commitments and behaviors. By analyzing the popular pro-ana site “MyPancakeAddiction,” I explore how anas embody this digital culture through performances of a shared value system rooted in commitments to individualism, self-control, and mastery – themes often associated with Protestantism.
Time Hurries on but Does not Fly in Older Age — No Effect of Depressive Symptoms
Authors: Thönes Sven , Wascher Edmund , Gajewski Patrick D. , Getzmann Stephan 
Published: January 2021

Abstract
Research on the commonly known phenomenon of perceived accelerated time passage with increasing age has provided inconsistent results. This could be due to a mediating time-slowing effect of depressive symptoms as the prevalence of depression does also alter with age. Based on a large sample of 380 subjects covering a continuous range of age between 20 and 70 years, we tested whether the assumed age-related effect on time perception is being mediated by symptoms of depression. Cross-sectional differences indicate a weak, but significant nonlinear acceleration of the perceived passage of time especially during mid-adulthood, whereas no further alteration was observed above the age of 60. In contrast to our hypothesis, symptoms of depression did clearly not mediate the effects of age on perceived time passage. Moreover, neither time passage ratings nor age were significantly related to the severity of depressive symptoms. Our results are partly compatible with (and extend) several previous reports, indicating that subjective time passage changes over the life span in a nonlinear fashion; they do not provide evidence for a mediating time-slowing effect of depressive symptoms in nonclinical samples.
Calculated globulin as a screening tool for hypogammaglobulinaemia or paraproteins in hospitalized patients
Authors: Hoo Teng , Lim Ee Mun , John Mina , D’Orsogna Lloyd , McLean-Tooke Andrew 
Published: January 2021

Background Calculated globulin fraction is derived from the liver function tests by subtracting albumin from the total protein. Since immunoglobulins comprise the largest component of the serum globulin concentration, increased or decreased calculated globulins and may identify patients with hypogammaglobulinaemia or hypergammaglobulinaemia, respectively. Methods A retrospective study of laboratory data over 2.5 years from inpatients at three tertiary hospitals was performed. Patients with paired calculated globulins and immunoglobulin results were identified and clinical details reviewed. The results of serum electrophoresis testing were also assessed where available. Results A total of 4035 patients had paired laboratory data available. A calculated globulin ≤20 g/L (<2nd percentile) had a low sensitivity (5.8%) but good positive predictive value (82.5%) for hypogammaglobulinaemia (IgG ≤5.7 g/L), with a positive predictive value of 37.5% for severe hypogammaglobulinaemia (IgG ≤3 g/L). Paraproteins were identified in 123/291 (42.3%) of patients with increased calculated globulins (≥42 g/L) who also had a serum electrophoresis performed. Significantly elevated calculated globulin ≥50 g/L (>4th percentile) were seen in patients with either liver disease (37%), haematological malignancy (36%), autoimmune disease (13%) or infections (9%). Conclusions Calculated globulin is an inexpensive and easily available test that assists in the identification of hypogammaglobulinaemia or hypergammaglobulinaemia which may prompt further investigation and reduce diagnostic delays.
Indian Railways Restructuring: Private Sector Involvement, A Beginning
Authors: Dhameja Nand L. , Dhameja Manish 
Published: January 2021

Indian Railways (IRs), the world’s fourth-largest network by size, has a route length covering approximately 68,155 km. It operates over 22,669 trains a day, sixty per cent of which are the ones transporting about 844 crore passengers and 123 crore tonnes of freight; two-third of its total revenue is from freight and only 27.3 per cent are passenger receipts. It is the eighth employer in the world employing about 1.227 people. It suffers from chronic under-investment, low-capacity augmentation, congestion, and over-utilisation, safety problems and poor-quality service, leading to poor morale, reduced efficiency, sub-optimal freight and passenger traffic, fewer financial resources; and deteriorating operating ratio. The government on the recommendations of a high-level committee suggested ways to mobilise resources and restructure the Railway Board; invited private sector companies to operate 151 trains over 100 routes by April 2023 bringing in an investment of ₹30,000 crore. The committee laid down a time frame of five years for implementation of its recommendations. The present study spread over five sections discusses observations and recommendations of the committee and suggests the outsourcing of some of its non-core functions like repair and maintenance workshops, manicuring units, washing of trains, security, and employees’ facilities like medical and education.
Public governance, agility and pandemics: a case study of the UK response to COVID-19
Authors: Joyce Paul 
Published: January 2021

The UK government’s leaders initially believed that it was among the best-prepared governments for a pandemic. By June 2020, the outcome of the collision between the government’s initial confidence, on the one hand, and the aggressiveness and virulence of COVID-19, on the other, was evident. The UK had one of the worst COVID-19 mortality rates in the world. This article explores the UK government’s response to COVID-19 from a public administration and governance perspective. Using factual information and statistical data, it considers the government’s preparedness and strategic decisions, the delivery of the government response, and public confidence in the government. Points for practitioners Possible lessons for testing through application include: Use the precautionary principle to set planning assumptions in government strategies to create the possibility of government agility during a pandemic. Use central government’s leadership role to facilitate and enable local initiative and operational responses, as well as to take advantage of local resources and assets. Choose smart government responses that address tensions between the goal of saving lives and other government goals, and beware choices that are unsatisfactory compromises.
Comparing effectiveness of fat burners and thermogenic supplements to diet and exercise for weight loss and cardiometabolic health: Systematic review and meta-analysis
Authors: Clark James E , Welch Sarah 
Published: January 2021

Background: Those who are overfat face an onslaught of advice for losing weight, including using dietary supplements that purport to have fat burning capabilities to achieve a reduced body mass, fat mass and improvement in cardiometabolic health in combination with exercise or diet and exercise regimens. Aim: To examine long-term effectiveness of supplements for both weight loss and improvements in cardiometabolic health for these individuals. Methods: A PRISMA methods of systematic review was conducted from August 2018 through January 2019 using Medline, PubChem, PubMed, EBOSCO CINHAL and SPORTDiscus, and Google Scholar yielding 23,441 returns of which 21 studies (duration greater than 8 weeks with participant populations of BMI greater than 24.9) were included for meta-analysis. Meta-analysis examined pooled effect size and 95% confidence interval for: body mass, fat mass, fat-free mass, total cholesterol, high-density lipoproteins, low-density lipoproteins, resting metabolic rate. Intra-study effect sizes were compared with previously reported results for diet or diet and exercise in a 2x2 chi-square analysis for the number of studies that induced effects greater than or less than the effect size. Results: There is a general trend to show effectiveness (effect size greater than 0.00) for obtaining beneficial changes from use of thermogenic dietary supplements, yet the 95% confidence interval for effect size crossed 0.00 (indicating no benefit). Chi-square comparison to exercise, or combination of diet and exercise, indicates that responses induced from weight-loss supplements were less effective than what is obtained from utilizing exercise, or diet and exercise, without additional weight-loss supplements. Conclusion: There appears to be limited benefit that may be derived from the inclusion of thermogenic dietary supplements to reduce body mass and improve cardiometabolic health for individuals who are overfat.
Additional value of deep learning computed tomographic angiography-based fractional flow reserve in detecting coronary stenosis and predicting outcomes
Authors: Li Yang , Qiu Hong , Hou Zhihui , Zheng Jianfeng , Li Jianan , Yin Youbing , Gao Runlin 
Published: January 2021

Background Deep learning (DL) has achieved great success in medical imaging and could be utilized for the non-invasive calculation of fractional flow reserve (FFR) from coronary computed tomographic angiography (CCTA) (CT-FFR). Purpose To examine the ability of a DL-based CT-FFR in detecting hemodynamic changes of stenosis. Material and Methods This study included 73 patients (85 vessels) who were suspected of coronary artery disease (CAD) and received CCTA followed by invasive FFR measurements within 90 days. The diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristics curve (AUC) were compared between CT-FFR and CCTA. Thirty-nine patients who received drug therapy instead of revascularization were followed for up to 31 months. Major adverse cardiac events (MACE), unstable angina, and rehospitalization were evaluated and compared between the study groups. Results At the patient level, CT-FFR achieved 90.4%, 93.6%, 88.1%, 85.3%, and 94.9% in accuracy, sensitivity, specificity, PPV, and NPV, respectively. At the vessel level, CT-FFR achieved 91.8%, 93.9%, 90.4%, 86.1%, and 95.9%, respectively. CT-FFR exceeded CCTA in these measurements at both levels. The vessel-level AUC for CT-FFR also outperformed that for CCTA (0.957 vs. 0.599, P < 0.0001). Patients with CT-FFR ≤0.8 had higher rates of rehospitalization (hazard ratio [HR] 4.51, 95% confidence interval [CI] 1.08–18.9) and MACE (HR 7.26, 95% CI 0.88–59.8), as well as a lower rate of unstable angina (HR 0.46, 95% CI 0.07–2.91). Conclusion CT-FFR is superior to conventional CCTA in differentiating functional myocardial ischemia. In addition, it has the potential to differentiate prognoses of patients with CAD.
Revision of failed metal-on-metal total hip arthroplasty using cemented arthroplasty: a mean 10-year follow-up of 157 consecutive patients
Authors: Lin Jinluan , Huang Chunlong , Yu Weiguang , Han Guowei , Liu Xiangzhen , Zeng Xianshang 
Published: January 2021

Objective This study was performed to assess the outcomes of Asian patients who underwent conversion from metal-on-metal total hip arthroplasty (MoM-THA) to cemented THA (CTHA). Methods One hundred and fifty-seven consecutive patients (157 hips) who underwent CTHA following primary MoM-THA from January 2005 to February 2015 were retrospectively analysed. The primary endpoints were the clinical outcomes. Follow-ups occurred at 3 months, 6 months, 1 year, 2 years, and then every 2 years following revision of MoM-THA. Results The mean follow-up after conversion was 10 years (range, 5–14 years). Statistically significant improvements in the mean Harris hip score were observed between the preoperative and final follow-up evaluations (62.71 ± 13.85 vs. 84.03 ± 16.21, respectively). The major orthopaedic complication rate was 16.5% (26/157). Six (3.8%) patients underwent revision at a mean of 3.5 ± 1.3 years after conversion, predominantly because of prosthesis loosening or recurrent dislocation. Nine (5.7%) patients developed prosthesis loosening at a mean of 2.6 ± 1.1 years following conversion, two of whom requested revision surgery. Eleven (7.0%) patients developed prosthesis dislocation, four of whom requested revision surgery. Conclusion CTHA may yield favourable functional outcomes and a reduced rate of major orthopaedic complications.
Physiologic and hemodynamic changes in patients undergoing open abdominal cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
Authors: Kim Myoung Hwa , Yoo Young Chul , Bai Sun Joon , Lee Kang-Young , Kim Nayeon , Lee Ki Young 
Published: January 2021

Objective We aimed to determine the physiological and hemodynamic changes in patients who were undergoing hyperthermic intraperitoneal chemotherapy (HIPEC) cytoreductive surgeries. Methods This prospective, observational study enrolled 21 patients who were undergoing elective cytoreductive surgery with HIPEC at our hospital over 2 years. We collected vital signs, hemodynamic parameters including global end-diastolic volume index (GEVI) and extravascular lung water index (ELWI) using the VolumeView™ system, and arterial blood gas analysis from all patients. Data were recorded before skin incision (T1); 30 minutes before HIPEC initiation (T2); 30 (T3), 60 (T4), and 90 (T5) minutes after HIPEC initiation; 30 minutes after HIPEC completion (T6); and 10 minutes before surgery completion (T7). Results Patients showed an increase in body temperature and cardiac index and a decrease in the systemic vascular resistance index. GEDI was 715.4 (T1) to 809.7 (T6), and ELWI was 6.9 (T1) to 7.3 (T5). Conclusions HIPEC increased patients’ body temperature and cardiac output and decreased systemic vascular resistance. Although parameters that were extracted from the VolumeView™ system were within their normal ranges, transpulmonary thermodilution approach is helpful in intraoperative hemodynamic management during open abdominal cytoreductive surgery with HIPEC. Trial registry name: ClinicalTrials.gov Trial registration number: NCT02325648 URL: https://clinicaltrials.gov/ct2/results?cond=NCT02325648&term
Use of medicinal plants for headache, and their potential implication in medication-overuse headache: Evidence from a population-based study in Nepal
Authors: Sørnes Elise Øien , Risal Ajay , Manandhar Kedar , Thomas Hallie , Steiner Timothy J , Linde Mattias 
Published: January 2021

Background In Nepal, traditional treatment using medicinal plants is popular. Whereas medication-overuse headache is, by definition, caused by excessive use of acute headache medication, we hypothesized that medicinal plants, being pharmacologically active, were as likely a cause. Methods We used data from a cross-sectional, nationwide population-based study, which enquired into headache and use of medicinal plants and allopathic medications. We searched the literature for pharmacodynamic actions of the medicinal plants. Results Of 2100 participants, 1794 (85.4%) reported headache in the preceding year; 161 (7.7%) reported headache on ≥15 days/month, of whom 28 (17.4%) had used medicinal plants and 117 (72.7%) allopathic medication(s). Of 46 with probable medication-overuse headache, 87.0% (40/46) were using allopathic medication(s) and 13.0% (6/46) medicinal plants, a ratio of 6.7:1, higher than the overall ratio among those with headache of 4.9:1 (912/185). Of 60 plant species identified, 49 were pharmacodynamically active on the central nervous system, with various effects of likely relevance in medication-overuse headache causation. Conclusions MPs are potentially a cause of medication-overuse headache, and not to be seen as innocent in this regard. Numbers presumptively affected in Nepal are low but not negligible. This pioneering project provides a starting point for further research to provide needed guidance on use of medicinal plants for headache.
Systematic Review of Elbow Instability in Association With Refractory Lateral Epicondylitis: Myth or Fact?
Authors: Kholinne Erica , Liu Hua , Kim Hyojune , Kwak Jae-Man , Koh Kyoung-Hwan , Jeon In-Ho 
Published: January 2021

Background: Elbow instability, particularly posterolateral rotatory instability (PLRI), has been reported in patients with refractory lateral epicondylitis (LE). However, evidence of diagnostic approach and surgical outcomes is lacking. Purpose: To identify (1) the risk factors, clinical and radiologic-diagnostic characteristics, and (2) the treatment options and clinical outcome of LE with PLRI. Study design: Systematic review. Methods: We searched the PubMed, Ovid/MEDLINE, Cochrane Library, Google Scholar, Scopus, and EMBASE databases using keywords as well as Medical Subject Headings terms and Emtree using “(lateral epicondylitis OR tennis elbow) AND (instability OR posterolateral rotatory instability)” for English-language studies. We conducted a systematic review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Results: In total, 8 articles comprising 6 level 4 and 2 level 3 studies were identified, including 249 patients (254 elbows). The main triggering factor was heavy labor activity (74/172; 43%). A total of 184 patients (73.9%) received either single (4/184; 2.2%) or multiple (180/184; 97.8%) steroid injections. Clinically, instability was always accompanied by pain in 9% of study individuals. Magnetic resonance imaging (MRI) revealed that radial collateral ligament (RCL) and lateral ulnar collateral ligament (LUCL) lesions were most common (18/79; 23%). The most common surgical procedure performed was arthroscopic RCL plication (62/120; 52%) followed by LUCL reconstruction (30/120; 25%). A ligament patholaxity sign was shown intraoperatively for 64% (44/69). Clinical outcomes ranged from good to excellent in all studies. The most common residual symptom was limited range of motion (11/18; 61%). Conclusion: Instability can coexist and may be associated with refractory LE. The risk factors of instability associated with refractory LE are heavy labor and multiple steroid injections. A systematic approach to identify the clinical and MRI presentation of the condition followed by examination under anesthesia are necessary for affirmative diagnosis, as independent presentations may be misleading.
Outcomes More Than 2 Years After Meniscal Repair for Longitudinal Tears of the Lateral Meniscus Combined With Anterior Cruciate Ligament Reconstruction
Authors: Tsujii Akira , Yonetani Yasukazu , Kinugasa Kazutaka , Matsuo Tomohiko , Yoneda Kenji , Ohori Tomoki , Hirose Takehito , Hamada Masayuki 
Published: January 2021

Background: Meniscal function after repair of longitudinal tears of the lateral meniscus (LM) with anterior cruciate ligament reconstruction (ACLR) has not been comprehensively investigated. Purpose: To evaluate not only the clinical outcomes and radiographic findings of patients who underwent repair of longitudinal tears of the LM combined with ACLR but also the healing status of the repaired meniscus and changes in chondral status with second-look arthroscopy. Study Design: Case series; Level of evidence, 4. Methods: Among 548 patients who underwent primary anatomic ACLR at our institution between 2010 and 2017, 39 who had concomitant longitudinal tears of the LM and underwent repair were studied. During follow-up for more than 2 years, all patients were evaluated clinically (pain, range of motion, swelling, and knee instability) and with imaging (plain radiograph and magnetic resonance imaging [MRI]), and compared with a matched control group (based on age, sex, body mass index, and follow-up period) without any concomitant injuries who underwent ACLR. Measurements on MRI were recorded preoperatively, immediately after surgery, and at final follow-up, and the change in the values over time was assessed. Of the 39 patients in each group, 24 were assessed by second-look arthroscopy with hardware removal 2 years postoperatively. Results: The mean follow-up times of the study and control group were at a mean of 42.4 and 45.4 months, respectively. There were no significant differences in clinical findings, lateral joint space narrowing on radiographs, and chondral status at the lateral compartment between groups, whereas lateral and posterior meniscal extrusion on MRI progressed significantly in the study group (0.43 ± 1.0 mm vs -0.29 ± 1.1 mm, P = .003; 1.9 ± 1.9 mm vs 0.14 ± 1.1 mm, P < .0001, respectively). Second-look arthroscopy revealed complete healing in 12 patients (50%), partial healing in 9 (37.5%), and failure in 3 (12.5%) in the study group, and no new tear in the control group. Conclusion: The clinical and imaging outcomes after repair of longitudinal tears of the LM combined with anatomic ACLR were successful and comparable with those after isolated ACLR without any other injuries at 42 months postoperatively, although meniscal extrusion showed progression on coronal/sagittal MRI. Based on the MRI findings and the result that only half of patients achieved complete healing, meniscal function could not be fully restored even after repair. Although degenerative changes were not apparent, longer-term follow-up is needed.