bluuebunny/crossref_metadata_2025_split huggingface dataset:
TO FIND OUT ETIOLOGY AND CLINICAL PROFILE OF PATIENTS OF ACUTE KIDNEY INJURY AT TERTIARY CARE CENTRE OF INDORE
Authors: Meena Kiran , Goyal Nikita , Verma Anjali , Mukhariya Rahul , Lad Divyesh 
Published: November 2021

Background & Method: Present Study was done with an aim to find out Etiology and clinical profile of patients of Acute Kidney Injury at Tertiary Care Centre of Indore. After taking institutional ethical clearance and written consent from the patients a cross sectional observational study was conducted on 100 Patients admitted in Intensive Care Unit of INDEX MEDICAL COLLEGE AND RESEARCH CENTRE who have clinical and / or biochemical evidence of acute kidney injury, detailed thorough history taking, general physical examination, systemic examination and routine and specific lab investigations, were done to find out the underlying etiology, clinical features and outcome of Acute Kidney Injury.
Result: This study includes various etiology of acute kidney injury in the current study. Most common cause being AGE (30%) followed by septicemia (16%) and poisoning (14%). In present study 75 % of cases were of Pre Renal AKI. Post Renal and Renal AKI was present in 13% and 12% respectively.
Conclusion: The variety of clinical features were recorded and studied, the most commonly observed clinical feature was oliguria closely followed by malaise and vomiting in acute kidney injury. Acute gastrointestinal infection was the most common cause of acute kidney injury. Other frequent causes were septicemia, poisoning, multi organ dysfunction syndrome.
Keywords: Etiology, clinical & Acute Kidney.
An Assessment of Inventory Management Practices at the Hospitality Management Department of Takoradi Technical University
Authors: Danso Bertha , Whyte Theodora Naa Maamle , Jnr. Peter Owusu-Akyaw , Fenteng Rita Adasi , Akyaa Loretta Akosua 
Published: November 2021

Inventory management encompasses a wide variety of tasks. These tasks differ depending on the organization. The study's main goal is to evaluate inventory management activities at Takoradi Technical University's hospitality management department. Non–experimental analysis was used to design the sample. The study's target population was hospitality students with sample sizes of 60 students. Purposive sampling was used to collect data for the analysis. The analysis relied on primary data. To collect data for the analysis, a structured questionnaire was created with both opened-ended and closed-ended questions. Statistical Package for Social Sciences (SPSS) and Microsoft Excel were used to analyze and process the information. Frequency distribution tables, pie charts, and bar charts were used to display the findings. According to the results, the department did a commendable job of resource management in order to provide supplies for the students' practical training. The department's inventory management process was purely commercial and the proper inventory management process was implemented. Regardless, it was recommended that the hospitality department strive to keep inventory under control. Evidence for inventory management and record documentation should also be handy at all times.
Penerapan Model Pembelajaran Inquiry untuk Meningkatkan Hasil Belajar Siswa pada Pelajaran Geografi dengan Materi Pokok Dinamika Kependudukan di Indonesia Kelas XI SMAN 10 Kota Jambi
Authors: Ermiwati Ermiwati 
Published: November 2021

This research aims to determine the effectiveness of student learning outcomes in Geography subjects with the subject of Population Dynamics in Indonesia class XI IPS 1 SMAN 10 Jambi using inquiry learning model. Population and samples in this study were students of class XI IPS 1, amounting to 30 students. The data obtained based on this study Based on the results obtained in the above study between the two cycles it can be obtained data that in cycle 1 the average value of student learning activities in first cycle was 2.6 while the average value in second cycle was obtained. amounted to 3,4. This shows that there is an increase in student learning activities. Based on the results obtained in the above research, between the two cycles, it can be obtained data that in first cycle the average value of teacher activity was 3.4, and the average value insecond cycle was 3.5. This shows that there is an increase in teacher activity. Based on the results obtained in the above research, especially on the subject of Population Dynamics in Indonesia, there are significant results on student learning completeness in first cycle and second cycle was 10%.
UPAYA PENINGKATAN KOSAKATA BAHASA INGGRIS MELALUI STORYTELLING SLIDE AND SOUND
Authors: Amelia Dina 
Published: November 2021

Pendidikan diselenggarakan dengan memberi keteladanan, membangun kemauan, dan mengembangakan kreativitas peserta didik dalam proses pembelajaran. Anak adalah sosok individu yang sedang berkembang dengan pesat dan fundamental bagi kehidupan selanjutnya. Anak pada usia masa ini anak berada pada usia 0-10 tahun sedang mengalami masa yang cepat dalam perkembangan hidup manusia (Uzer, 2019). Sekolah Tunas Mekar Indonesia adalah sekolah national plus yang menggunakan bahasa pengantar bahasa Inggris. Akan tetapi, sejak masa pandemic Covid 19 dan pembelajaran online dimulai, kemampuan siswa untuk dapat memahami materi dan menghafal kosakata serta berbicara dalam bahasa Inggris menurun, terutama anak-anak di kelas 5 SD. Permasalahan tersebut juga dipicu oleh metode pembelajaran yang tidak bervariasi. Metode ceramah dan tanya jawab merupakan hal yang paling seering digunakan di ruang kelas. Metode yang digunakan tim PkM Sastra Inggris Universitas Teknokrat Indonesia demi meningkatan kosakata bahasa Inggris adalah melalui storytelling Slide and Sound. Sebagian besar peserta pelatihan PkM Storytelling Slide and Sound memberikan respon cepat dan tepat sehingga mengalami peningkatan kosakata cukup signifikan selama masa pelatihan. Sementara Sebagian kecil siswa masih mengalami kesulitan dalam Menyusun kata dikarenakan kurangnya kosakata. Akan tetapi, semua siswa merassakan dampak positif dan semua siswa mau bekerjasama dan mencoba metode belajar tersebut.
Fast-Strain Encoded Cardiac Magnetic Resonance During Vasodilator Perfusion Stress Testing
Authors: Steen Henning , Montenbruck Moritz , Kelle Sebastian , Esch Sebastian , Schwarz Arne Kristian , Giusca Sorin , Korosoglou Grigorios 
Published: November 2021

Background: Cardiac magnetic resonance perfusion imaging during vasodilator stress is an established modality in patients with suspected and known coronary artery disease (CAD).Aim: This study aimed to evaluate the performance of fast-Strain-Encoded-MRI (fast-SENC) for the diagnostic classification and risk stratification of patients with ischemic heart disease.Methods: Perfusion and fast-SENC cardiac magnetic resonance (CMR) images were retrospectively analyzed in 111 patients who underwent stress CMR. The average myocardial perfusion score index, global and segmental longitudinal and circumferential strain (GLS and GCS and SLS and SCS, respectively), were measured at rest and during stress. The combination of SLS and SCS was referred to as segmental aggregate strain (SAS). Segments exhibiting perfusion defects or SAS impairment during stress were defined as “ischemic.” All-cause mortality, non-fatal infarction, and urgent revascularization were deemed as our combined clinical endpoint.Results: During adenosine stress testing, 44 of 111 (39.6%) patients exhibited inducible perfusion abnormalities. During a mean follow-up of 1.94 ± 0.65 years, 25 (22.5%) patients reached the combined endpoint (death in n = 2, infarction in n = 3 and urgent revascularization in n = 20). Inducible perfusion defects were associated with higher number of segments with inducible SAS reduction ≥6.5% (χ2 = 37.8, AUC = 0.79, 95% CI = 0.71–0.87, p &lt; 0.001). In addition, patients with inducible perfusion defects or SAS impairment exhibited poorer outcomes (AUCPerf = 0.81 vs. AUCSAS = 0.74, p = NS vs. each other, and χ2 = 30.8, HR = 10.3 and χ2 = 9.5, HR = 3.5, respectively, p &lt; 0.01 for both).Conclusion: Purely quantitative strain analysis by fast-SENC during vasodilator stress was related to the diagnosis of ischemia by first-pass perfusion and is non-inferior for the risk stratification of patients with ischemic heart disease. This may bear clinical implications, especially in patients with contraindications for contrast agent administration.
Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
Authors: Gong Boshen , Wang Chuyuan , Meng Fanrui , Wang Haoyu , Song Bo , Yang Yang , Shan Zhongyan 
Published: November 2021

BackgroundAutoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with AITD has altered, but no studies have conducted systematic reviews on the association between gut microbiota and ATID.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane databases without language restrictions and conducted a systematic review and meta-analysis of eight studies, including 196 patients with AITD.ResultsThe meta-analysis showed that the alpha diversity and abundance of certain gut microbiota were changed in patients with AITD compared to the controls. Chao1,the index of the microflora richness, was increased in the Hashimoto’s thyroiditis group compared to controls (SMD, 0.68, 95%CI: 0.16 to 1.20), while it was decreased in the Graves’ disease group (SMD, -0.87, 95%CI: -1.46 to -0.28). In addition, we found that some beneficial bacteria like Bifidobacterium and Lactobacillus were decreased in the AITD group, and harmful microbiota like Bacteroides fragilis was significantly increased compared with the controls. Furthermore, the percentage of relevant abundance of other commensal bacteria such as Bacteroidetes, Bacteroides, and Lachnospiraceae was increased compared with the controls.ConclusionsThis meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.Systematic Review RegistrationPROSPERO, identifier CRD42021251557.
Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank
Authors: Wang Lijie , Si Shucheng , Li Jiqing , Li Yunxia , Chen Xiaolu , Xue Fuzhong , Ren Wangang 
Published: November 2021

BackgroundThe triglyceride-glucose (TyG) index is a practical substitute measure for insulin resistance (IR). The relationship between IR and lung cancer has been examined in previous studies; however, the findings have been controversial. In addition, previous studies had small sample sizes. Thus, we systematically examined the association between IR and lung cancer risk based on the UK Biobank with IR measured by the TyG index and further examined the interactions and joint effects for lung cancer.MethodsA total of 324,334 individuals free from any type of cancer at recruitment from the UK Biobank prospective cohort were included. The participants were predominantly between 40 and 70 years old. After adjusting for relevant confounders, multivariable Cox regression models were constructed to examine the relationship between the TyG index and the risk of lung cancer. We also checked the interactions and joint effects using a polygenic risk score (PRS) for lung cancer.ResultsDuring a median follow-up of 9 years, 1,593 individuals were diagnosed with lung cancer. No association was found between the TyG index and lung cancer risk after multivariate Cox regression analysis adjusted for risk factors (hazard ratio: 0.91; 95% confidence interval: 0.64–1.18). No interaction or joint effects for genetic risk and the TyG index were observed.ConclusionThe TyG index was not associated with the risk of lung cancer. Our results provide limited evidence that IR is not correlated with the risk of lung cancer.
Multimodal Imaging Technology Effectively Monitors HER2 Expression in Tumors Using Trastuzumab-Coupled Organic Nanoparticles in Patient-Derived Xenograft Mice Models
Authors: Wen Li , Xia Lei , Guo Xiaoyi , Huang Hai-Feng , Wang Feng , Yang Xian-teng , Yang Zhi , Zhu Hua 
Published: November 2021

Trastuzumab is a monoclonal antibody targeting human epidermal growth factor 2 (HER2), which has been successfully used in the treatment of patients with breast cancer and gastric cancer; however, problems concerning its cardiotoxicity, drug resistance, and unpredictable efficacy still remain. Herein, we constructed novel organic dopamine–melanin nanoparticles (dMNs) as a carrier and then surface-loaded them with trastuzumab to construct a multifunctional nanoprobe named Her-PEG-dMNPs. We used micro-PET/CT and PET/MRI multimodality imaging to evaluate the retention effect of the nanoprobe in HER2 expression in gastric cancer patient-derived xenograft (PDX) mice models after labeling of the radionuclides 64Cu or 124I and MRI contrast agent Mn2+. The nanoprobes can specifically target the HER2-expressing SKOV-3 cells in vitro (3.61 ± 0.74 vs. 1.24 ± 0.43 for 2 h, P = 0.002). In vivo, micro-PET/CT and PET/MRI showed that the 124I-labeled nanoprobe had greater contrast and retention effect in PDX models than unloaded dMNPs as carrier (1.63 ± 0.07 vs. 0.90 ± 0.04 at 24 h, P = 0.002), a similarity found in 64Cu-labeled Her-PEG-dMNPs. Because 124I has a longer half-life and matches the pharmacokinetics of the nanoparticles, we focused on the further evaluation of 124I-Her-PEG-dMNPs. Furthermore, immunohistochemistry staining confirmed the overexpression of HER2 in the animal model. This study developed and validated novel HER2-specific multimodality imaging nanoprobes for quantifying HER2 expression in mice. Through the strong retention effect of the tumor site, it can be used for the promotion of monoclonal antibody treatment effect and process monitoring.
Anti-Angiogenesis Maintenance Therapy in Newly Diagnosed and Relapsed Ovarian Cancer: A Meta-analysis of Phase III Randomized Controlled Trials
Authors: Wang Yizi , Zhang Shitai , Song Zixuan , Ouyang Ling , Li Yan 
Published: November 2021

Aim: Anti-angiogenesis agents have been added as maintenance therapy in ovarian cancer over the past decade. The aim of this meta-analysis was to analyze the efficacy of anti-angiogenesis therapy in newly diagnosed and relapsed ovarian cancer.Methods: PubMed, Embase, and Cochrane databases were searched for all phase III randomized controlled trials (RCTs) that assessed the efficacy and toxicity of anti-angiogenesis agents in ovarian cancer. Overall survival (OS) and progression-free survival (PFS) were used to evaluate the effectiveness of anti-angiogenesis therapy in ovarian cancer.Results: A total of 6097 patients with newly diagnosed ovarian cancer from 5 phase III RCTs and 2943 patients with relapsed ovarian cancer from 6 phase III RCTs were included in this meta-analysis. The pooled results showed that anti-angiogenesis maintenance therapy significantly improved PFS (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.76–0.93; p = 0.001), but not OS (HR, 0.98; 95% CI, 0.91–1.05; p = 0.49) compared with placebo in patients with newly diagnosed ovarian cancer. In patients with relapsed ovarian cancer, the pooled results showed a significant improvement on OS (HR, 0.89; 95% CI, 0.82–0.98; p = 0.02) and PFS (HR, 0.61; 95% CI, 0.52–0.72; p &lt; 0.001). The pooled results also showed that the anti-angiogenesis agents were associated with an increase in the occurrence of severe hypertension, neutropenia, diarrhea, thrombocytopenia, headache, and bleeding in ovarian cancer. However, infrequent fatal adverse events occurred in the anti-angiogenesis groups.Conclusions: Study results suggest that anti-angiogenesis agents were an effective therapy for newly diagnosed and relapsed ovarian cancer, especially for relapsed ovarian cancer. Anti-angiogenesis agents may be associated with some severe but not fatal adverse events.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42021283647
Barriers and Facilitators to Seeking Sleep Solutions for Children With Cerebral Palsy: A Qualitative Study
Authors: Petersen Sacha , Reddihough Dinah S. , Lima Sally , Harvey Adrienne , Newall Fiona 
Published: November 2021

Background: Published evidence to date suggests that sleep problems are common in children with cerebral palsy (CP). This qualitative study is a follow up to a previously published quantitative phase on the experience and impact of sleep problems in this population.Aims: The aim of this study was to explore the experience and impact of sleep disturbance and seeking of sleep solutions for parents of school aged children with CP.Materials and Methods: Semi-structured 19 qualitative interviews were conducted with parents of children with CP aged 6–12 years. Interview data were transcribed verbatim and the thematic analysis techniques by Braun and Clarke was used to identify themes.Results: Thematic analysis identified 7 themes: (1) My Child Doesn't Fit into the Box, (2) A Mother's Ears are Always On, (3) Sleep Disturbance is like Water Torture, (4) Sleep is One of Many Spot Fires, I Put it on the Backburner, (5) Luck, Money or Jumping Up and Down, (6) There is Never One Silver Bullet and (7) Help: The Earlier the Better. The key finding was that parents of children with CP often described their child's needs being distinct from what is provided by systems and services.Conclusion: Parents face significant challenges sourcing effective sleep solutions for their child with CP. Sleep is often not a priority for either the parent or the clinician as other health problems take precedence. Parents reflected that early sleep intervention for their child was or would have been helpful. The barriers and facilitators to sleep care identified in this study should be used to inform clinical change in care for children with CP. Sleep needs to be prioritized in healthcare for children.
Indicadores de calidad de colangiopancreatografía retrógada endoscópica en un hospital nivel III asociados al desarrollo de pancreatitis aguda post-cpre
Authors: Pérez Acuña-Medina Katherine Alexandra , Díaz-Vélez Cristian 
Published: November 2021

Objetivo: Evaluar la asociación entre los indicadores de calidad de colangiopancreatografía retrógada endoscópica (CPRE) y desarrollo de pancreatitis aguda post-CPRE en el Hospital Regional Lambayeque durante el período 2016–junio 2017. Material y métodos: estudio observacional, transversal analítico, retrospectivo. Población censal 539 y muestra 358. Se evaluaron historias clínicas usando un checklist de indicadores de calidad de “The American Society for Gastrointestinal Endoscopy (ASGE)”. Se usó media y desviación estándar para la edad y frecuencias absolutas y porcentajes para las demás variables. Se evaluó el porcentaje de cumplimiento de cada indicador. Se encontró la asociación entre indicadores de calidad y el desarrollo de pancreatitis usando razones de prevalencia (IC95%) y X2(p<0,05). Resultados: La edad promedio es 52,24+20,168, el 66,5% son mujeres. 98,3% de las CPREs tiene indicación apropiada; 0,3% no tiene consentimiento informado completo; 15,38% tuvo administración de antibiótico adecuada; 92,2% fueron realizadas por un endoscopista capacitado; en 96,9% se logró la canulación profunda, ninguno tuvo medición del tiempo de fluoroscopio, 65,1% logró extracción de cálculos <1cm, 95,5% logró la colocación de stent; ninguna tuvo reporte completo y en el 98,5% los efectos adversos fueron documentados. La tasa de pancreatitis fue 7%, de perforación 0,6% y de hemorragia 2,5%. Solo el 3,9% tuvo control en >14 días. Conclusiones: No existe asociación entre los indicadores de calidad de CPRE y el desarrollo de pancreatitis. No se cumplen todos los criterios de calidad. La pancreatitis post-CPRE tiene más posibilidad de presentarse en mujeres, pero menos en mayores de 65 años.
SWCNTs Interaction with Dopamine and Serotonin Anticancer Through QM/MM Methods: A Drug Delivery Approaches
Authors: Saghayi Marouf Nastaran , Monajjemi Majid , Zare Karim , Shamel Ali 
Published: November 2021

Objetive: Dopamine and Serotonin are the two important biological transmitters that have hormonal activities and responsible for happiness and felling well. The aim of this article was to study theoretically the structure features of Dopamine and Serotonin in the complex of single-walled carbon nanotube as a neurotransmitter. Material and Methods: The structure of Dopamine and Serotonin binding with SWCNT with four different diameters (7.0,7.5,7.7,10.0 nm) was studied by using molecular mechanic (MM) and quantum mechanic (QM). The remarkable energies including potential energy, total energy and kinetic energy in time of simulation 10 ns steps in two temperatures (298, 310 kelvin degree) were investigated by Monte Carlo method with opls force filed. NMR shielding tensor data by B3LYP level of theory with 6-31 G(d) as a basis set and semi empirical method have been also fulfilled. Results: Theoretical computations were performed to study NMR chemical shift data including magnetic shielding tensor (σ, ppm), shielding asymmetry (η), magnetic shielding anisotropy (σaniso), magnetic shielding isotropy (σiso) , skew of a tensor (Κ) and chemical shift anisotropy (Δσ) and span (Ω) at various rotation angles around a specific rotation, physical and chemical properties of atomic nuclei. Semi empirical calculations such as total energy, binding energy, isolated atomic energy, electronic energy, core–core interaction and heat of formation in AM1 were revealed. Conclusion: It is figured out in Monte Carlo method our two specific drug and its nanotube with small diameter are the most stable one than the others. The larger diameter leads the combination stability into lower value.