bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silicon Compounds in Sponges
Authors: Drozdov Anatoliy L. , Zemnukhova Lyudmila A. , Panasenko Alexandr E. , Polyakova Nataliya V. , Slobodyuk Arseniy B. , Ustinov Alexandr Yu. , Didenko Nina A. , Tyurin Sergey A. 
Published: July 2021

A comparative study of the microscopic morphology and chemical characteristics of spicules of Hexactinellids (Hexactinellida) with different structural features of the skeletons, as well as the freshwater Baikal sponge belonging to the class of common sponges (Demospongia), was carried out. The trace element composition of sponge spicules was determined by X-ray fluorescence spectrometry. The spicules of siliceous sponges contain many elements, arranged in decreasing order of concentration: Si, Ca, Fe, Cl, K, Zn, and others. It was shown that the surface layer of sea sponges contains mainly carbon (C), oxygen (O), and to a lesser extent nitrogen (N), silicon (Si), and sodium (Na). The spicules of the studied siliceous sponges can be divided into two groups according to the phase composition, namely one containing crystalline calcium compounds and one without them. Analysis of infrared absorption spectra allows us to conclude that the sponges Euplectella aspergillum, E. suberia and Dactylocalyx sp. contain silica partially bound to the organic matrix, while the silica skeleton of the sponges of the other group (Schulzeviella gigas, Sericolophus sp., Asconema setubalense, Sarostegia oculata, Farrea sp. and Lubomirskia baicalensis sp.) practically does not differ from the precipitated SiO2. This comparative study of the chemical composition of the skeletons of marine Hexactinellids and common freshwater sponge allows us to conclude that there are no fundamental differences in the chemical composition of spicules, and all of them can be used as a starting material for creating new composite silicon–organic functional materials.
Characterization and Clinical Utility of BRAFV600 Mutation Detection Using Cell-Free DNA in Patients with Advanced Melanoma
Authors: Rutkowski Piotr , Pauwels Patrick , Kerger Joseph , Jacobs Bart , Maertens Geert , Gadeyne Valerie , Thielemans Anne , de Backer Katrien , Neyns Bart 
Published: July 2021

Tissue-based tests for BRAFV600 mutation-positive melanoma involve invasive biopsy procedures, and can lead to an erroneous diagnosis when the tumor samples degrade. Herein, we explored a minimally invasive, cell-free deoxyribonucleic acid (cfDNA)-based platform, to retest patients for BRAFV600 mutations. This phase 2 study enrolled adult patients with unresectable/metastatic melanoma. A prescreening testing phase evaluated the concordance between a prior tissue-based BRAFV600 mutation test result and a subsequent plasma cfDNA-based test result. A treatment phase evaluated the patients who were confirmed as BRAFV600 mutation-positive, and were treated with cobimetinib plus vemurafenib. It was found that 35/54 patients (64.8%) with a mutant BRAF status by prior tissue test had a positive BRAFV600 mutation with the cfDNA test. Further, 7/118 patients (5.9%) with a wild-type BRAF status had a positive BRAFV600 mutation cfDNA test; tissue retests on archival samples confirmed BRAFV600 mutation positivity in 5/7 patients (71.4%). One of these patients received BRAF pathway-targeted therapy (cobimetinib plus vemurafenib), and had progression-free survival commensurate with previous experience. In the overall cobimetinib plus vemurafenib-treated population, 29/36 patients (80.6%) had an objective response. The median progression-free survival was 13.6 months (95% confidence interval, 9.5–16.5). Cell-free DNA–based tests may be a fast and convenient option to identify BRAF mutation status in melanoma patients, and help inform treatment decisions.
Localized Atrial Tachycardia and Dispersion Regions in Atrial Fibrillation: Evidence of Spatial Concordance
Authors: Gitenay Edouard , Bars Clément , Bremondy Michel , Ayari Anis , Maillot Nicolas , Baptiste Florian , Taormina Antonio , Fofana Aicha , Siame Sabrina , Kalifa Jérôme , Seitz Julien 
Published: July 2021

Introduction: During atrial fibrillation (AF) ablation, it is generally considered that atrial tachycardia (AT) episodes are a consequence of ablation. Objective: To investigate the spatial relationship between localized AT episodes and dispersion/ablation regions during persistent AF ablation procedures. Methods: We analyzed 72 consecutive patients who presented for an index persistent AF ablation procedure guided by the presence of spatiotemporal dispersion of multipolar electrograms. We characterized spontaneous or post-ablation ATs’ mechanism and location in regard to dispersion regions and ablation lesions. Results: In 72 consecutive patients admitted for persistent AF ablation, 128 ATs occurred in 62 patients (1.9 ± 1.1/patient). Seventeen ATs were recorded before any ablation. In a total of 100 ATs with elucidated mechanism, there were 58 localized sources and 42 macro-reentries. A large number of localized ATs arose from regions exhibiting dispersion during AF (n = 49, 84%). Importantly, these ATs’ locations were generally remote from the closest ablation lesion (n = 42, 72%). Conclusions: In patients undergoing a persistent AF ablation procedure guided by the presence of spatiotemporal dispersion of multipolar electrograms, localized ATs originate within dispersion regions but remotely from the closest ablation lesion. These results suggest that ATs represent a stabilized manifestation of co-existing AF drivers rather than ablation-induced arrhythmias.
Perencanaan Strategi Sistem Informasi untuk Mendukung Proses Bisnis Hotel XYZ
Authors: Nastiti Putri , Kesuma Alwi , Johannes Marvin Ariel , Immanuel Christian 
Published: July 2021

Hotel merupakan salah satu contoh infrastruktur yang dapat mendukung pariwisata di suatu daerah. Di era digital seperti saat ini, banyak hotel yang melakukan pemasaran digital supaya dapat menjangkau lebih banyak wisatawan. Hal ini menjadi bentuk nyata bahwa sistem informasi menjadi landasan bagi pengembangan sebuah organisasi modern, salah satunya adalah industri perhotelan. Oleh karenanya setiap organisasi perlu didukung oleh rancangan arsitektur sistem informasi untuk pengembangan bisnis organisasinya. Arsitektur perusahaan akan mendukung model bisnis fungsional yang dapat disesuaikan dengan berbagai macam kegiatan pelayanan publik. Penelitian ini mengambil objek Hotel XYZ yang terletak di kota Yogyakarta. Arsitektur perusahaan pada penelitian ini akan dilakukan berdasarkan langkah-langkah dalam kerangka kerja The Open Group Architecture Framework (TOGAF). Tahapan yang dilakukan meliputi arsitektur visi, arsitektur bisnis, arsitektur data, arsitektur aplikasi, dan arsitektur teknologi. Alat analisis yang digunakan dalam penelitian ini diantaranya adalah analisis rantai nilai, analisis SWOT, dan business model canvas. Selain itu penelitian ini juga menghasilkan usulan aplikasi sistem informasi dan rencana arsitektur teknologi, yaitu sebuah sistem perbaikan untuk unit front office, dimana sistem all in one control yang saat ini dimiliki oleh Hotel XYZ dengan basis data terpusat dapat terintegrasi dengan platform afiliasi sistem tiket lainnya menggunakan API. Usulan strategi SI untuk unit front office ini juga didukung dengan usulan arsitektur teknologinya. Implementasi perencanaan SI/TI ini akan mendukung proses bisnis Hotel XYZ menjadi lebih efektif dan efisien.
Perancangan Enterprise Architecture Sistem Informasi Terminal Menggunakan Model TOGAF ADM (Studi Kasus: Terminal Tipe B Palabuhanratu)
Authors: Marlianti Risa Sri , Saepudin Sudin 
Published: July 2021

Terminal Palabuhanratu merupakan terminal penumpang tipe B yang merupakan terminal utama terbesar di kawasan Sukabumi bagian selatan. Terminal ini terletak di Jalan Pasar Palabuhanratu, Desa Palabuhanratu, Kecamatan Palabuhanratu, Kabupaten Sukabumi. Terminal yang dikelola oleh Dinas Perhubungan Provinsi Jawa Barat ini menyediakan pelayanan angkutan Mobil Penumpang Umum (MPU), angkutan perintis, dan angkutan antar kota. Pengelola Terminal Tipe B Palabuhanratu belum mengimplementasikan Enterprise Architecture (EA) untuk menyelaraskan strategi SI/TI dengan strategi bisnisnya. Dalam implementasinya, pihak pengelola Terminal Tipe B Palabuhanratu memberikan pelayanan informasi dengan baik kepada calon penumpang, walaupun belum terstruktur secara sistematis dalam penerapan perancangan SI/TI sehingga proses pelayanan untuk kegiatan bisnis belum berjalan secara maksimal. Umumnya dalam memberikan informasi layanan transportasi mengenai waktu pemberangkatan, rute tujuan, tarif, dan pengaduan. Penelitian ini bertujuan untuk membuat sebuah Perancangan Enterprise Architecture untuk pengelolaan layanan transportasi dan pelayanan pengaduan di Terminal Tipe B Palabuhanratu dengan menggunakan model TOGAF ADM dan akan menghasilkan sebuah blue print yang nantinya dapat digunakan sebagai acuan dalam mengimplementasikan pembuatan sistem, sehingga pengelola terminal dapat dengan mudah memberikan informasi dan dapat meningkatkan pelayanan di Terminal Tipe B Palabuhanratu. Metode penelitian ini menggunakan model TOGAF Architecture Development Method (ADM) untuk mendukung Perancangan Enterprise Architecture Sistem Terminal Tipe B Palabuhanratu.
Experiencia de la enfermera ante la muerte del paciente pediátrico, una construcción desde la fenomenología
Authors: Vázquez Sánchez Deysi , Hernández Rodríguez Verónica Margarita , Castruita Sánchez María del Carmen , Álvarez Aguirre Alicia 
Published: July 2021

Objetivo: Describir la experiencia de la enfermera ante la muerte del paciente pediátrico. Método: Investigación cualitativa, fenomenológica. La recolección de información se efectúo a través de entrevista fenomenológica con pregunta orientadora formulada en grupo focal, se recogió la experiencia de 19 enfermeras del Hospital de Especialidades del Niño y la Mujer. El análisis se realizó con técnica de análisis de contenido, de forma tradicional, por lo que no se empleó ningún software para el mismo. En lo respectivo a la ética en el estudio, se otorgó consentimiento informado y respetó la voluntad, así como la libertad en la participación. Resultados principales: Los testimonios narrados develaron cuatro categorías temáticas, las cuales se ubican según el orden de aparición en las hablas, a la primera se le denominó “factores determinantes”, a la segunda “experiencias negativas”, seguidas de la denominada “experiencias positivas” y “aprendizajes”. Se observa un mayor desglose de experiencias negativas, pero se constata que las experiencias positivas, permiten al profesional de enfermería darle un sentido a su práctica disciplinar y a su vida personal. Conclusión general: Los resultados permiten afirmar que las enfermeras que atraviesan por el proceso de duelo ante la muerte de un paciente, son muy diversas entre sí, sin embargo, se observa que el vivir de forma cerca y constante la pérdida de personas significativas, les permite afrontar la vida con una actitud reconstruida de sí mismas.
Descriptores (indicando identificador único): experiencia, muerte del paciente pediátrico, personal de Enfermería, fenomenología.
Nivel de conocimiento y práctica preventiva en la población afectada con dengue, Ferreñafe, 2019
Authors: Bravo Rodriguez Pamela del Carmen , Zapata Rueda Aurora Violeta 
Published: July 2021

Objetivo: Identificar la relación que existe entre el nivel de conocimiento y la práctica preventiva en personas afectadas con dengue, Ferreñafe 2019. Método: Estudio cuantitativo con diseño descriptivo correlacional. La muestra estuvo conformada por 252 personas afectadas con el virus del dengue, el muestreo fue por conveniencia teniendo en cuenta los criterios de inclusión y exclusión. Se utilizó como técnica la encuesta y como instrumento un cuestionario para medir el nivel de conocimiento y una lista de chequeo para la práctica preventiva elaborado por García, Torres y Tangoa, se validaron los instrumentos a nivel local con el método de Kuder de Richardson teniendo 0.890 y 0.820 de confiabilidad respectivamente. Resultados principales: Sí existe una relación positiva perfecta y directamente proporcional relación con significancia bilateral (rs = 0.858, p = 0.000) entre nivel de conocimiento y práctica preventiva en la población afectada con dengue. Por lo que se rechaza la hipótesis nula
Conclusión general: A mayor rango de nivel de conocimiento que presente la persona afectada con dengue, la práctica preventiva que desarrolle es muy buena o viceversa.
Descriptores: Dengue (D003715), Conocimiento (D019359), Prevención de enfermedades (50219)
Cuidados paliativos durante la pandemia por la COVID-19
Authors: Rodriguez Cruz Lisseth 
Published: July 2021

Para el año 2060 calculan que la necesidad de los cuidados paliativos en el mundo aumentará un 85%1. Durante la pandemia por la COVID-19, los cuidados paliativos (CP) han cobrado una necesidad imperante para cuidar y acompañar a las personas infectados por SARS-CoV-2 en situación de últimos días y a su familia o cuidadores. Sin embargo, muchos pacientes en esta situación han muerto solos2, puesto que en las instituciones de salud no han contado con el acompañamiento de un familiar por prevención al contagio3. Estas pautas de actuación conllevan una serie de condiciones que atentan los derechos del paciente, con especial relevancia al final de vida, como el derecho a una muerte digna y al acompañamiento, y que contribuyen a un elevado número de muertes en soledad2.
En este contexto, varios profesionales de la salud intentaron reconfortar a los pacientes mediante el mantenimiento de la comunicación de la familia con su paciente por vía telefónica, videollamadas, cartas -hechos aparentemente tan sencillos- pero muy gratificantes en esos momentos. Para ello, si el paciente estaba consciente se aprovechaba cuando se informaba de la evolución para hacer contacto con el familiar.
Ciertamente, la situación se complicaba cuando a los pacientes COVID-19 en fase terminal se sumaban los pacientes oncológicos en la misma situación debido a que los servicios de salud no estaban preparados para proporcionar cuidados paliativos por la falta de infraestructura, financiamiento, y formación profesional. Desde luego, se añadía el impacto emocional sobre el profesional sanitario por el miedo inherente al contagio del virus3, pues a pesar de usar equipos de protección profesional (EPP) la mayoría se contagió y algunos fallecieron. También porque todos los pacientes permanecían en el mismo ambiente; situación que generaba mucha angustia por no poder brindar la atención cercana, individualizada y compasiva, atendiendo a todos los niveles de sufrimiento que por desgracia afloran en estos casos4. Así mismo, porque en algunos casos han presenciado o escuchado el llanto desgarrador por no poder despedirse de las personas próximas al fallecido. Estas circunstancias invitan a reflexionar acerca de la muerte digna como un éxito terapéutico y un derecho fundamental que merece ser protegido en condiciones normales y también en situación de crisis5.
En ese sentido, se recomienda reconsiderar aspectos del cuidado humano tan sencillos como la caricia, la empatía, el toque terapéutico, la conversación, la escucha, las medidas de confort, el cuidado personalizado, reflexionar sobre la vulneración de los derechos del paciente al final de vida, la demanda del cuidado espiritual. Precisamente porque estas circunstancias reclaman la presencia de otro acompañando, ofreciendo unas palabras de consuelo o buscando algún remedio que alivie.
J. S. Bach’s Church Cantatas and Church Music Today
Authors: Tantra Carolien Eunice , Peters Mark 
Published: July 2021

How do we as Christians today learn about worship and church music? How do we think about not only what music we will sing in Christian worship, but also the principles that should guide us in choosing and leading church music? Certainly, there are many different ways we answer that question: we study the Bible, we sing the words of the Scriptures, we read what theologians, worship leaders, and scholars of church music are writing today, we attend lectures and conferences by scholars and practitioners of church music. In this article, I offer and explore yet another example of how we live out God’s call in leading music for the Christian church: by studying the example of a faithful Christian musician from the past. My particular example for this article is the German composer and church musician Johann Sebastian Bach (1685-1750). I want to clarify from the start that I am not arguing that J. S. Bach is the best example of a Christian church musician and certainly not that he is the only example. But Bach does offer us one example of a musician who dedicated most of his life to creating and leading music for the Christian church and sought to do so faithfully, creatively, and skillfully.
PREFERENCE IN LANGUAGE LEARNING STRATEGIES (LLS) OF THE STUDENTS IN THE ENGLISH LANGUAGE EDUCATION DEPARTMENT AT THE UNIVERSITY OF MUHAMMADIYAH JEMBER
Authors: Hidayah Taufik 
Published: July 2021

The present study aims at investigating the patterns of language learning strategy use employed by the sixth semester students of English language education program at the University of Muhammadiyah Jember. To achieve this objective, Oxford’s Strategy Inventory of Language Learning (SILL) (1990) along with a background questionnaire (a modified version of Oxford’s background questionnaire) were administered to the participants. The findings indicate that the research participants use language learning strategies at a high rate (more than 60%), but with differences in type and frequency of the individual learning strategies. The students reported a high frequent use of metacognitive and cognitive strategies. Other types of language learning strategies are also used by the students, although the frequency is lower than the previous two strategies. Based on the findings of the present study, some pedagogical implication were suggested to encourage students to reflect on their own strengths and weaknesses in skills and content courses and self-regulate learning so as to make progress with teachers’ assistance.
Keywords: language learning strategies (LLS); Strategy Inventory of Language Learning (SILL); memory strategies; cognitive strategies; metacognitive strategies; socio-affective strategies; compensation strategies.
COLLEGE STUDENT’S PROBLEMS IN WRITING PARAGRAPH ( A CASE STUDY AT FOURTH SEMESTER STUDENTS OF INFORMATICS MANAGEMENT OF AMIK MITRA GAMA)
Authors: Melati Eka 
Published: July 2021

The purpose of this study is to analyze problems faced by the college students of the Informatics Management study program at AMIK Mitra Gama in writing a paragraph. This study was descriptive qualitative research. The participants of this research were fourth-grade students of the Informatics Management study program attending the Applied English II course and registered on the 2018/2019 academic year, 31 students. Instrumentation of this research was student’s paragraph writing entitled “Computer in the Digital Age” in 100-150 words and interview. The result of this study found that the students had the organization of paragraph, grammatical and mechanics problems in writing a paragraph. The most typical difficulty was the organization of paragraph problems in writing concluding sentences (90,3%). Secondly, grammatical problem in using adjective (77,4%), article (64,5%), and verb (58,1%). Third, mechanics problem in punctuation (38,7%). Lastly, based on the interview, these problems arise from the students' used Google Translate more often in finishing their writing. They translated their paragraph in Bahasa Indonesia into English directly without paying attention to the aspects of writing a paragraph. It made them difficult in choosing the appropriate words. For the next study, it was suggested to further investigate another aspect of grammatical (preposition, transition word, and conjunctions) and mechanics of writing such as content and organization. It implies that writing skills should be included in course design to enhance student’s ability in writing.
STUDENTS’ PRAGMATIC AWARENESS IN COMPREHENDING WRITTEN DISCOURSE OF ENGLISH DEPARTMENT OF IAIN BUKITTINGGI
Authors: Minanda Nofa , Eliza Eliza , Dewi Merry Prima 
Published: July 2021

Knowledge of pragmatic has been crucial element to the students English Department. The main focus of the research to find out the level of students pragmatic awareness by using percentage, the research was due to the problem found some students still used inappropriate respond to the pragmatic situation. The design of this research was a descriptive quantitative research in which the sample was taking by using random sampling technique with 25 samples at IAIN Bukittinggi of English Department. Additionally, the analyzing of the data was done by Written Discourse Completion Test (WDCT) test which is consist of 17 situation, made the description about the students pragmatic awareness in comprehending written discourse, analyzing the data using percentage, describe the data, found the level and making conclusion. The result showed that students pragmatic awareness in comprehending term in deixis is 61% it means the level is good. In performing term of speech act is 79% it means the level is good. Moreover, in understanding maxim is 62% it means the level is good. All of the students pragmatic awareness in comprehending written discourse is 67% it means the pragmatic awareness in comprehending written discourse of English Department of IAIN Bukittinggi is good. The implication of this study to know the level of pragmatic awareness in written discourse of English Department of IAIN Bukittinggi.
LOGICAL FALLACIES ON STUDENTS’ ARGUMENTATIVE WRITING
Authors: Lismay Leli 
Published: July 2021

In writing an argumentative paragraph, there will be some fallacies that can be explained as students’ misunderstanding in interpreting source language to target language, in this context English is as a target language. This misunderstanding called logical fallacies where it can broke the meaning in TL. Therefore, the aim of this research was to identify and analyze types of logical fallacies done by the fourth semester students in argumentative writing at English department of IAIN Bukittinggi. The design of this research was descriptive quantitative. The population was the fourth semester students who take writing for professional context subject. The sample was 28 students. The instrument used was documentation of student’s argumentative writing tasks. The result showed that, some informal logical fallacies found in students’ writing. 76% students wrote inductive fallacy on their writing which means that students drew a conclusion without providing enough evidence on their writing.