bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial Correlates of Death Anxiety in Advanced Cancer: A Scoping Review
Authors: Brown Tyler L. , Chown Philippa , Solomon Sheldon , Gore Genevieve , De Groot Janet M. , MacKinnon Christopher J. , Rodin Gary , Sanders Justin J. 
Published: December 2024

ABSTRACTObjectivesIndividuals living with advanced cancer commonly experience death anxiety, which refers to the distressing thoughts or feelings associated with awareness of one's mortality. Deriving an overview of existing literature on the psychological and social factors linked to death anxiety may inform conceptual models, clinical screening, and intervention strategies in oncology and palliative care. Therefore, the present scoping review was conducted to summarize the current literature on the psychosocial correlates of death anxiety among individuals with advanced cancer.MethodsA comprehensive scoping review methodology was used following the Arksey and O'Malley framework. A literature search was conducted using four electronic databases: CINAHL, Embase, PsycInfo, and MEDLINE. Abstracts and full‐text articles were screened, and relevant data were extracted and summarized.ResultsSixteen studies met the inclusion criteria. Seventeen psychosocial correlates of death anxiety were identified, with depression, spiritual well‐being, and attachment security representing the most frequently investigated. Four previously tested death anxiety models were also identified, two of which were designed longitudinally.ConclusionsThis review provides a current summary of psychosocial factors and established models related to death anxiety in advanced cancer. Multiple psychosocial correlates should be targeted concurrently in research and clinical practice to address death anxiety. Longitudinal studies designed to test new models are especially needed to identify unique pathways contributing to death anxiety across the disease trajectory of advanced cancer.
In Search of Candidate Protein Biomarkers Related to COVID‐19 in Solid Tissues and Non‐Blood Fluids: An Update
Authors: Alexovič Michal , Uličná Csilla , Tabani Hadi , Sabo Ján 
Published: December 2024

ABSTRACTPurposeDuring COVID‐19, significant changes in protein abundance can be linked with disease‐related processes. The mass spectrometry–based proteomics of COVID‐19‐related biomarkers can help with the prognosis and diagnosis of this severe disease.DesignHere, we surveyed scientific works in terms of proteomic analysis of solid tissues and non‐blood fluids from COVID‐19 patients. Works published since 2022 to date have been covered.ResultsBrain, lymph nodes, heart, spleen, aorta walls, liver, adrenal gland and kidneys were investigated as solid organs/tissues. The non‐blood fluids involved exhaled breath particles, airway mucus, saliva, swabs, colostrum/milk and urine. The provided table depicts studies/experimental platforms to analyse COVID‐19‐related candidate protein biomarkers.ConclusionEven eminent research input has been made in this field, continuation towards deeper findings should be made. Translation of proteomics into the clinics to help with diagnostics and therapeutical strategies, is a highly important task. The analysed candidate protein biomarkers are the perspective molecules for pending clinical decisions making and treatments.
Low‐Intensity Exercise Protects Skeletal and Cardiac Muscle Against Cancer‐Mediated Muscle Wasting via Regulation of Autophagy and Inflammation
Authors: Tichy Louisa , Parry Traci L. 
Published: December 2024

ABSTRACTBackgroundUp to 80% of cancer patients suffer from skeletal and cardiac muscle wasting, also known as cancer cachexia. This metabolic wasting syndrome is responsible for up to one‐third of deaths in these cancer patients. Treatment options to attenuate muscle loss are limited. However, research shows that exercise interventions can slow tumour development and preserve muscle mass and function. Questions remain regarding the most effective modalities of exercise as a preventative intervention against cancer‐mediated muscle wasting. The purpose of this study was to determine if low‐intensity treadmill exercise can act as a protective measure and intervention against cancer‐mediated muscle wasting in male mice.MethodsMale LC3 Tg+ and WT mice were randomly separated into four groups: sedentary non‐tumour bearing (SED + NT), sedentary tumour bearing (SED + T), low‐intensity treadmill exercise non‐tumour bearing (TM + NT) and low‐intensity treadmill exercise tumour bearing (TM + T). Mice were implanted with tumour cells (T group; 5 × 105 LLC cells in flank) or remained non‐tumour (NT) for 4 weeks. During the 4 weeks, mice underwent a low‐intensity treadmill training protocol (TM) or remained sedentary (SED). Grip strength, echocardiography and tumour growth was assessed, and inflammatory and autophagic protein pathways in skeletal and cardiac muscle tissue were investigated.ResultsSED + T mice exhibited worst grip strength and cardiac function (fractional shortening). Coinciding with worse skeletal and cardiac function, inflammatory and autophagic pathways were abnormally upregulated in SED + T mice compared with NT controls (p < 0.05). Low‐intensity exercise protected musculature by cardiac function and grip strength in TM + T compared with SED + T mice. Low‐intensity exercise attenuated inflammation and autophagy in TM + T mice. Additionally, treadmill exercise resulted in significantly smaller tumour mass and volume (p < 0.05) in the TM + T compared with SED + T group.ConclusionsOur data indicated cardioprotective, myoprotective and tumour‐suppressive effects of low‐intensity treadmill exercise in tumour bearing mice. Low‐intensity exercise preserved skeletal and cardiac muscle function and inhibited tumour growth by regulating autophagy and inflammation. Therefore, low‐intensity treadmill exercise may be an effective, affordable and accessible adjuvant treatment for cancer patients.
Macroeconomic Drivers of Sustainable Tourism Development in Bangladesh: An ARDL Bounds Testing Approach
Authors: Kuri Bapon Chandra , Nahiduzzaman Md. , Dhar Bablu Kumar , Shabbir Rubaiyat , Karim Rejaul 
Published: December 2024

ABSTRACTTourism serves as a critical driver of economic development, yet its relationship with macroeconomic and socio‐political factors remains underexplored in emerging economies like Bangladesh. This study examines the long‐run and short‐run impacts of macroeconomic drivers, including CO₂ emissions, GDP growth, inflation, population growth, road safety, refugee population, and tourism services, on inbound tourism in Bangladesh, employing the Autoregressive Distributed Lag (ARDL) bounds testing approach. The findings reveal that while CO₂ emissions have a short–term positive impact associated with industrial growth, they negatively affect tourism in the long run due to environmental degradation. Road safety challenges and socio‐political instability, including terrorism and refugee influx, significantly deter tourism. Conversely, improvements in infrastructure positively influence tourism demand over time. By integrating sustainability into tourism strategies, this research highlights the alignment of tourism development with Sustainable Development Goals (SDGs), such as SDG 8 (Decent Work and Economic Growth), SDG 13 (Climate Action), and SDG 9 (Industry, Innovation, and Infrastructure). Practical implications include adopting cleaner energy initiatives, improving road safety, and fostering inclusivity through gender‐focused entrepreneurship and refugee integration. This study contributes to the theoretical understanding of sustainable tourism in developing nations and offers actionable insights for policymakers aiming to balance economic growth with environmental and social considerations.
Synthesis and Multi‐Target Inhibition of Bis‐Schiff Bases of Barbituric Acid: in Vitro α‐glucosidase, α‐amylase Inhibitory Activities With Docking and DFT Studies
Authors: Zahir Mahnoor , Alam Aftab , Jan Faheem , Khan Ajmal , AlAsmari Abdullah F. , Alasmari Fawaz , Khan Momin , Al‐Harrasi Ahmed 
Published: December 2024

AbstractThe current research is based on the synthesis of some novel bis‐Schiff bases bearing barbituric acid moiety followed by characterization through modern spectroscopic techniques and their in vitro inhibitory effects against the enzymes α‐glucosidase and α‐amylase were subsequently investigated. In the series, four compounds 8 (IC50 = 5.62 ± 0.18 and 3.12 ± 0.13 µM), 10 (IC50 = 7.13 ± 1.03 and 8.19 ± 1.11 µM), 9 (IC50 = 12.81 ± 1.92 and 12.11 ± 1.32 µM), and 11 (IC50 = 15.07 ± 0.38 and 16.01 ± 0.28 µM) attributed notable dual inhibition against α‐glucosidase and α‐amylase enzymes better than the standard acarbose drug (IC50 = 16.16 ± 0.15 and 16.65 ± 0.17 µM). The molecular docking study was performed to explored the binding affinities and key interactions of synthesized compounds with targeted proteins (α‐amylase and α‐glucosidase). Furthermore, the stability of all the compounds were verified by density functional theory (DFT) method at B3LYP/6–311++G(d,p). For the account of intramolecular interaction, DFT‐D3 and reduced density gradient (RDG) methods were utilized. In addition, utilising the CAM‐B3LYP functional with 6–311++G(d,p), the TD‐DFT approach was used to examine different reactivity circumstances.
Zinc Complexes with Mixed Ligands and the Effect on Excitation and Emission Spectra by Changing the Binding Sites
Authors: Li Shixiong , Feng Xiaojing , Chen Huijun , Xu Shihua 
Published: December 2024

AbstractFluorescence properties of mixed‐ligand zinc(II) complexes may be affected by the interactions between different ligands, resulting in more complex fluorescence behavior due to the discrepancy between energy levels. In this paper, three zinc(II) complexes: {[Zn2(L1)2(CO3)](H2O)}n (1), [Zn(L2)(H2O)3]n (2), and [Zn8(L1)8(L2)4(H2O)4]n (3) were obtained by using 3‐amino‐1,2,4‐triazole (HL1) and 5‐hydroxyisophthalic acid (H2L2) as organic linkers. X‐ray single crystal diffraction shows that 1 can be described as the dinuclear zinc SBUs bridged through L1− and CO32− to form a 2‐D structure. Complex 2 features the L22− linkers connecting mononuclear Zn(II) in μ2‐η1:η1 fashion to generate an 1‐D structure, and the adjacent chains were packed through hydrogen bonds to assemble a 2‐D structure. However, 3 is characterized the eight‐core zinc units concatenated by L1− and L22− to acquire a 3‐D structure. An obvious red‐shift of 73 nm, and 76 nm emerges in solid‐state fluorescence emission spectrum of 3 compared with HL1 and H2L2, which is also stronger than that of 1 and 2. Such phenomenon is mainly caused by the richer binding sites with Zn(II) in 3 deriving from mixed ligands, which is not only conducive to increase the stability of the complex but also to reduce the possibility of nonradiative transitions.
One‐Pot Synthesis of Magnetically Recyclable Fe3o4@Uio‐66 Composite with Enhanced Oxytetracycline Adsorption Capacity
Authors: Liu Zhanmeng , Lu Mang , Gan Haitao , Li Jiacheng , Gao Guiqing , Xu Manqing , Wang Xianglian 
Published: December 2024

AbstractAs one of the most stable metal‐organic frame materials (MOFs), UiO‐66 has attracted extensive attention in the adsorption field. However, the application of UiO‐66 is still constrained by the weak electron‐hole charge separation capability and the low accessibility of micropores. In this study, the mesoporous defects of UiO‐66 were constructed with acetic acid and doped with Fe3O4 to prepare magnetically recyclable Fe3O4@UiO‐66. The doping of Fe3O4 resulted in the formation of denatured mesoporous defects in UiO‐66, which was conducive to adsorption oxytetracycline (OTC) in water. The crystal structure and physicochemical characteristics of Fe3O4@UiO‐66 were examined. By using the static adsorption technique, the adsorption characteristics and mechanism of OTC on Fe3O4@UiO‐66 were investigated. The results reveal that Fe3O4@UiO‐66 has an adsorption capacity of 210 mg g−1 and an OTC removal ratio of 84.0%. The pseudo‐second‐order kinetics, Elovich, and Langmuir isothermal adsorption models were all applicable to the adsorption process. The adsorption process increased entropy and was an endothermic reaction. Solution pH has a little effect on the adsorption performance. This study provides the possibility of one‐step synthesis of MOFs that can efficiently adsorb tetracycline antibiotics in water with low cost and excellent recyclability and reusablity.
Structural Color Contact Lenses from Cholesteric Cellulose Liquid Crystals
Authors: Zhang Zhuohao , Pan Meidie , Yang Xinyuan , Shang Luoran , Zhao Yuanjin 
Published: December 2024

AbstractColored contact lenses have gained popularity among young individuals owing to their ability to alter the appearance of the wearer's eyes. However, conventional lenses containing chemical dyes are susceptible to detachment of the pigment layer, which can lead to corneal damage. In this research, a novel cellulose‐based structural color contact lens (SCCL) is presented that enhances aesthetic appeal via a cholesteric liquid crystal (CLC) layer. Methacrylate‐functionalized hydroxypropyl cellulose (HPCMA) molecules self‐assemble into CLC and are cross‐linked within the lens mold, resulting in the colored iris region of the contact lens. By employing multistep polymerization techniques, lenses with composite colors and intricate shapes are fabricated. Moreover, by incorporating bioderived antimicrobial peptides into the structurally colored region of the lens, SCCLs are achieved with good biocompatibility, controlled drug release, and broad‐spectrum antibacterial activity. The results of in vivo experiments using an animal model indicate that the SCCLs perform well in the treatment of bacterial keratitis. It is believed that these drug‐loaded structurally colored contact lenses will lead to various advancements in ocular medical devices and provide antibacterial protection against infectious keratitis in the future.
Evaluation of Boerhaavia diffusa roots extract as a sustainable corrosion inhibitor for mild steel in sulfuric acid environments
Authors: Nunach Amit Kumar , Rani Gita , Ahlawat Rachna , Kumar Harish 
Published: December 2024

AbstractMild steel (MS) is a widely used type of steel because of its different types of qualities like versatility, affordability, and ease of modification. On the other hand, its vulnerability to corrosion may somewhat detract from its merits. To mitigate the corrosion impacts various techniques are applied. The use of corrosion inhibitors remains one of the most effective strategies to prevent corrosion, especially in environments where sustainability is increasingly important. In this study, we evaluated the corrosion‐inhibiting properties of Boerhaavia diffusa (BHD) root extract in various concentrations (1–6%) on mild steel (MS) in an acidic solution (0.1 M H2SO4). To characterize the functional groups present in the BHD extract, Fourier‐transform infrared spectroscopy (FTIR) was employed. A combination of methods, including weight loss measurements, electrochemical polarization, electrochemical impedance spectroscopy (EIS), metallurgical research microscopy (MRM), and scanning electron microscopy (SEM), were used to assess the effectiveness of corrosion inhibition. BHD extract showed a maximum corrosion inhibition efficiency (IE) of 86.58% and the maximum charge transfer resistance (Rct) of 308 Ω cm2 was recorded for 6% concentration at 25 °C. This research study was carried out at 25, 35 and 45 °C. The study revealed that BHD is an excellent green corrosion inhibitor.
Community-Based Approaches to Respond to Epidemics and Natural Disasters in Coastal Ecuador
Authors: Díaz Avriel , Jeffery Andrew , Cedeño Ismelda , Pallaroso Yessenia , Jaramillo Gloria , Mera Rodriguez Blas , Wonsey Breana , Zambrano Margarita , Cedeño Rodriguez David 
Published: December 2024

AbstractEffective disaster response starts well before the disaster strikes. International aid, research, and recovery work must involve collaborations in which partners are working together at every stage to co-develop and co-create research that can help inform decision-making and establish sustainable programming and prevention initiatives. These partnerships require consistent engagement with community leaders, collaboration across levels of government, and comprehensive team training. Established channels for fundraising are essential for an organization to succeed in the face of chaotic disaster conditions. In this case study, we share our experience with Walking Palms Global Health (WPGH), a non-profit organization serving the communities of Bahía de Caráquez, Ecuador. Through WPGH, we continue to navigate disaster relief and recovery and foment well-being in our community. Our team has worked in the field during two emerging disease outbreaks, extreme weather events, and natural disasters, leading emergency relief efforts, and collaborating with local stakeholders and international institutions to implement holistic, long-term public health research and programming alongside partner communities.
Funding for Equitable Infectious Disease Research and Development
Authors: Mwoka Meggie 
Published: December 2024

AbstractResearch and development (R&D) are critical to develop effective solutions to address the prevention, control, elimination, and even eradication of infectious diseases globally. Financing global health and infectious diseases research is complex. It involves diverse and overlapping sources of funding; multiple recipients and mechanisms of funding; limited coordination, and lack of comprehensive data and impact assessment. Public funding for neglected diseases mainly comes from high income governments and multilateral organizations. Domestic contribution by most LMICs governments to R&D remains low and reliant on external funding from HICs. As a result, funding priorities may not always be aligned to country priorities.Funding for research and development of infectious diseases has largely focused on HIV, TB and malaria, however with the pandemic, there is increasing focus on pandemic preparedness and response, and platform technologies for vaccine delivery and general diagnostics. Several initiatives have been developed over the years to address gaps in the research funding landscape such as establishment of public private partnerships including product development partnerships.Shifting disease burdens and demographic changes, re-emergence and emergence of epidemic prone diseases in the face of climate change and a high globalized world, is impacting current and future approaches to infectious disease research and thus the funding priorities. Advancements have been made in establishing research institutions especially in LMICs in collaboration with HICs partners. However systemic challenges persist at institutional, political and global level limiting the growth of research and development especially in LMICs. Addressing these challenges at domestic level will require governments to take on greater responsibility towards investments in research, while leveraging external partnerships to strengthen and sustain relevant research and development that meets country and global needs.
Foundations and Future Directions of Global Health Communication
Authors: Adam Maya , Gates Jennifer , Mbewu Nokwanele , Bärnighausen Till 
Published: December 2024

AbstractGlobally, lack of equitable access to easy-to-understand health information leaves many people poorly equipped to understand their health—and vulnerable to misinformation. In response to this need, health communication specialists must develop innovative, theory-driven approaches to engaging diverse populations with compelling messages. As we develop our approaches to health communication, we must address the needs of our audience, taking into account their education, language, literacy level, or cultural affiliations. If our goal is to reach the broadest spectrum of people worldwide, the guiding question for anyone designing global health messages should be: How do we make science-based health messages accessible to diverse, global audiences, some of whom rarely seek out health information through traditional public health platforms? In this chapter, we will explore the need for global health communication, some basic theoretical foundations of health communication, and recent innovations in this arena. We hope you will feel our passion for this exciting field and consider building it into your career. Helping our fellow global citizens to be engaged and informed participants in the care of their health is a critical step towards improving health outcomes. This is the primary goal of effective global health communication.
Collective Learning: Power and Trust in Partnerships in the 3D Program for Girls and Women in Rural Pune District, India
Authors: Nowrojee Sia , Gupte Manisha 
Published: December 2024

AbstractThis chapter describes lessons learned through the partnerships jointly facilitated by the 3D Program for Girls and Women and Mahila Sarvangeen Utkarsh Mandal (MASUM) in rural Pune District, India, from 2017 to 2021. The analysis is done from our different perspectives, as one partner based in India and the other in the United States. We describe our process of joint learning as we navigated our own North-South partnership and other multi-sectoral partnerships; advanced gender equality by putting girls and women at the center of partnerships and decision-making; held those in power accountable to protect the rights of girls and women; adapted through COVID-19; and worked together intentionally on different ‘sides’ of our partnership. We explore power and trust within our own partnership and in the other partnerships we facilitated to address social determinants of health and advance gender equality. We highlight how different priorities and needs among stakeholders enriched the process when power differentials were managed in a spirit of trust and camaraderie, within a process of identifying and working towards shared commitments. Based on this analysis, we share lessons we learned and key tenets for global health and international development partnerships.
Challenges of Earthquake and Micro-Earthquake Monitoring in Sri Lanka
Authors: Matsunami Koji , Sassa Kyoji , Weerasinghe Ranjan , Munasinghe Tania , Doan Loi 
Published: December 2024

AbstractSite amplification effects of Aranayake landslide area in Sri Lanka are analyzed using records observed by a wide dynamic-range earthquake motion array with soil- and rock-site stations. We find that the rock site on the mountain ridge does not have the same response as the rock site at the foot of mountain, which has a characteristic frequency-dependent site effect. The relative amplification of the mountain ridge rock site to the mountain foot rock site is nearly 1.0 at frequencies of 2 < f < 6 Hz, having a peak of 2 or more at 6 to 8 Hz, that gradually decreases with increasing frequency, and becomes less than 1 above 10 Hz. On the land slide slope in Aranayake, clear resonant vibration with a frequency of nearly 12 Hz and an amplification of about 20 times is found from the amplification analysis of the main part of the S-wave. The vibration is excited immediately after P-wave arrival and continues to S-wave coda. Particle motions of a 12-Hz component in main portion of the S-wave show that the vibration is almost horizontal, and that its predominant direction nearly matches the landslide axis, but gradually changes with time according to the direction of stress free. From the survey of seismic activity in Aranayake landslide area, it is determined that microearthquakes with Ts-p < 1.0 s and the velocity magnitude 2 < M < 3 occur several ten times a month. The landslide slope is frequently attacked by such microearthquakes, and is shaken by the 12-Hz resonant vibration.