bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to Establish a Minimal Invasive and Stable Carotid Artery Stenosis Rabbit Model? A Simple and Effective Carotid Artery Balloon Strain Technique
Authors: Liu Zhengli , Gong Maofeng , Zhao Boxiang , Gu Jianping , Su Haobo , Zhou Yangyi , Fu Guanqi , He Xu , Kong Jie 
Published: November 2021

Background: The objective of this study is to establish a minimally invasive technique to create a stable carotid artery stenosis rabbit model. This article summarizes the specific methods and key points of this technology.Methods: The experiment studied a rabbit that was anesthetized through the vein. After the femoral artery was exposed, a minimally invasive needle was used to puncture the femoral artery, then the sheath was placed into the artery. We primarily put a catheter in the ascending aorta for angiography and then used a PT2 guidewire for super-selection. The PT2 guidewire was retained, and a balloon was placed in the right common carotid artery (CCA) through a guidewire to inflate it three times. Six rabbits in the 2- (2W) and 4-week (4W) groups were examined at 14 and 28 days, respectively. The rabbits in the control group received angiography at the beginning and 28 days later but without balloon injury. After angiography assessment, specimens of right CCA were dissected. Pathological and immunohistochemical examinations were performed on the collected specimens, and iFlow analysis was performed as well.Results: All the 18 animals which survived were observed. The rabbits in the 2W and 4W groups showed stenosis of the right CCA. Digital subtraction angiography showed the diameter was lower than that in the control group (1.04 ± 0.1, 0.71 ± 0.12, and 1.83 ± 0.08 mm in 2W, 4W, and control group, P &lt; 0.05). Pathology also suggested carotid stenosis and obvious intimal hyperplasia. The results of immunohistochemistry showed that α-smooth muscle actin was highly expressed in the 2W and 4W groups, and the integrated optical density (IOD) value was higher than that in the control group (14,807.11 ± 1,822.3, 22,245.96 ± 1,212.82, and 6,537.16 ± 1,186.62 in the 2W, 4W, and control group, P &lt; 0.05). Meanwhile, a cluster of differentiation 31 (CD31) was low expressed in the 2W and 4W groups, and the IOD value was lower than that in the control group (519.14 ± 44.4, 1,029.64 ± 98.48, and 1,502.05 ± 88.79 in the 2W, 4W, and control group, P &lt; 0.05), which suggested endothelial damage and partial repair. The analysis by iFlow showed that the time-to-peak after balloon strain in the 2W and 4W groups were longer than that in the control group.Conclusion: We established a minimally invasive, effective, and safe method to establish a carotid artery stenosis rabbit model. The highlights of this technology were the application of minimally invasive methods, reducing surgical bleeding, infection, and related complications. This technology avoided the influence of tissue around CCA in the traditional carotid artery balloon injury model, which might lead to more accurate treatment outcomes.
Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury
Authors: Barbe Mary F. , Panibatla Siva Tejaa , Harris Michele Y. , Amin Mamta , Dorotan Jocelynne T. , Cruz Geneva E. , Bove Geoffrey M. 
Published: November 2021

Background: Repetitive strain injuries caused by repetitive occupational work are difficult to prevent for multiple reasons. Therefore, we examined the effectiveness of manual therapy (MT) with rest to treat the inflammation and fibrosis that develops through the performance of a repetitive task. We hypothesized that this treatment would reduce task-induced sensorimotor declines and neuromuscular inflammation.Methods: Twenty-nine female Sprague-Dawley rats performed a reaching and lever-pulling task for 14weeks. All ceased performing the task at 14weeks. Ten were euthanized at this timepoint (TASK). Nine received manual therapy to their upper extremities while resting 7weeks (MTR); 10 were assigned to rest alone (REST). Ten additional food restricted rats were included that neither performed the task nor received manual therapy (FRC).Results: Confirming previous experiments, TASK rats showed behavioral changes (forepaw mechanical hypersensitivity, reduced grip strength, lowered forelimb/forepaw agility, and noxious cold temperature sensitivity), reduced median nerve conduction velocity (NCV), and pathological tissue changes (myelin degradation, increased median nerve and muscle inflammation, and collagen production). Manual therapy with rest (MTR) ameliorated cold sensitivity seen in REST rats, enhanced muscle interleukin 10 (IL-10) more than in REST rats, lead to improvement in most other measures, compared to TASK rats. REST rats showed improved grip strength, lowered nerve inflammation and degraded myelin, and lowered muscle tumor necrosis factor alpha (TNFα) and collagen I levels, compared to TASK rats, yet maintained lowered forelimb/forepaw agility and NCV, and increased neural fibrosis.Conclusion: In our model of repetitive motion disorder, manual therapy during rest had modest effects on behavioral, histological, and physiological measures, compared to rest alone. These findings stand in contrast to the robust preventive effects of manual therapy in this same model.
Does the Presence of Anxiety and Depression Symptoms Mediate the Association Between Family Functions and Self-Efficacy in Pregnant Women in the Third Trimester?: A Community-Based Cross-Sectional Survey
Authors: Wensu Zhou , Xidi Zhu , Shaojie Li , Baohua Zheng , Yunhan Yu , Huilan Xu , Zhao Hu , Xiyue Xiong 
Published: November 2021

Objectives: Pregnant women in the third trimester can be more vulnerable to adverse mental health outcomes, but there is limited research on the association between family function and self-efficacy and potential mediation by symptoms of anxiety and depression.Methods: The cross-sectional study enrolled 813 pregnant women in the third trimester from 14 communities of Hengyang city, Hunan province of China. All of the participants completed a battery of self-report measures of family function (Family Adaptation Partnership Growth and Resolve Index, APGAR-family), self-efficacy (General Self-Efficacy Scale, GSES), anxiety (measured by Generalized Anxiety Disorder scale with seven items, GAD-7), and depression symptoms (Patient Health Questionnaire with nine items, PHQ-9). The correlation analysis was performed using Spearman's correlation coefficient. Baron and Kenny's method and multiple mediation models with bootstrapping were used to determine whether the symptoms of anxiety and depression mediated the association between family functions and self-efficacy.Results: There were 22.6% pregnant women in the low level of self-efficacy, with 60.9% in the moderate level and 16.5% of respondents in the high level. Self-efficacy had significant correlations with both anxiety symptoms (r = −0.19, p &lt; 0.05), depression symptoms (r = −0.22, p &lt; 0.05), and family function (r = 0.31, p &lt; 0.05). Anxiety symptoms were significantly associated with self-efficacy (β = −0.016, p &lt; 0.05). Depression symptoms were significantly associated with self-efficacy (β = −0.024, p &lt; 0.05). Anxiety and depression symptoms partly mediated the association between family function and self-efficacy, accounting for 11.4 and 16.4% of total effect, respectively. It was indicated that pregnant women with a high degree of family function are less likely to have emotional symptoms and predicted to have higher levels of self-efficacy.Conclusions: Anxiety and depression show mediating effects in the association between family function and self-efficacy. Improved family function can have a positive impact on pregnant women in the third trimester.
Evaluation of the Acceptability of a Prenatal Program for Women With Histories of Childhood Trauma: The Program STEP
Authors: Berthelot Nicolas , Drouin-Maziade Christine , Garon-Bissonnette Julia , Lemieux Roxanne , Sériès Thibaut , Lacharité Carl 
Published: November 2021

Background: Childhood trauma would negatively affect pregnant women's mental health and would have intergenerational repercussions. However, there is a paucity of prenatal interventions specifically designed for women exposed to childhood trauma. The study aims to evaluate the acceptability of STEP, a manualized group intervention designed for pregnant women having experienced early life adversity.Methods: The acceptability of STEP was assessed in four phases. In Phase 1, six experts evaluated whether the program activities were pertinent and trauma sensitive. In Phase 2, three parents read the intervention manuals and evaluated whether they considered each session relevant, interesting, and clear. In Phase 3, the program was briefly presented by phone to 309 pregnant women from the community. Women were inquired about their interest in the program, and the reasons for their lack of interest were assessed. In Phase 4, 30 pregnant women exposed to childhood trauma participated in the program and completed anonymous satisfaction questionnaires after each session. Psychological distress was also measured before and after the program.Results: All activities were rated by independent experts as highly pertinent, adequate, and sufficiently safe to be offered to pregnant women. Parents who read through the intervention manuals also considered that the sessions were relevant, clear, and interesting. About half of the pregnant women from the community showed interest in the program. Participants reported very high levels of satisfaction and a significant decrease in psychological distress during the program.Conclusions: Our findings show a high level of convergence among various indicators of program acceptability.
Mental Health and Integration: A Qualitative Study on the Struggles of Recently Arrived Refugees in Germany
Authors: Walther Lena , Rayes Diana , Amann Julia , Flick Uwe , Ta Thi Minh Tam , Hahn Eric , Bajbouj Malek 
Published: November 2021

Introduction:Forcibly displaced people are at particular risk of mental health problems and also face specific integration challenges upon resettlement. Existing literature suggests that there may be a bidirectional relationship between mental health and integration. The present study seeks to understand the relationship between integration processes and mental health problems or significant negative emotional experiences among adult refugees in Germany.Method:Applying a qualitative approach, we conducted 54 semi-structured interviews with refugees and asylum seekers who arrived in Germany between 2013 and 2018 currently residing in Berlin, Leipzig, or the Duisburg area in North Rhine-Westphalia. Data was collected between December 2018 and September 2019. We analyzed transcripts inductively using thematic analysis.Results:Five themes covering the various links between integration and mental health problems or significant negative emotional experiences were identified. First, we found that the mental health consequences of past adverse experiences, as well as ongoing worries about those left behind in the homeland, can seriously impede refugees' ability to pursue activities key to integration. Second, the process of applying for and securing asylum can result in uncertainty and fear, which, in turn, burden the individual and may impact motivation for integration. Third, many of our participants described mental health ramifications related to feeling stuck and thwarted in the pursuit of building a life, especially in securing employment. Fourth, some participants described feeling so overwhelmed by fundamental tasks throughout the integration process, namely, language learning and bureaucratic processes, that these take a psychological toll. Fifth, we identified several forms of social disconnection between refugees and members of the host community due to xenophobia, social and cultural differences, physical and emotional isolation in refugee camps, as well as with co-nationals and fellow refugees. Negative emotions, mistrust, and socio-cultural differences that emerge throughout the integration processes seem to erode social cohesion among refugee communities, potentially further threatening mental health.Conclusion:Mental health problems and integration processes appear to be closely related across different areas of integration. Innovative solutions to challenges identified by members of the refugee community in Germany stand to benefit mental health and integration outcomes simultaneously.
Interplay Between Adherence to the Mediterranean Diet and Lipid Profile: A Comparative Survey Between Day-Time Healthcare and Non-healthcare Female Workers
Authors: Di Lorenzo Luigi , Vimercati Luigi , Pipoli Antonella , Manghisi Nicola Mariano , Lampignano Luisa , Caputi Antonio , De Maria Luigi , Zupo Roberta , De Pergola Giovanni 
Published: November 2021

Introduction: Occupational physicians, as an aspect of the periodic health surveillance of workers prescribed by law, must develop preventive programs against adverse health-related occurrences (Legislative Decree 81/2008, art.25) to reduce major risk factors for non-communicable/chronic diseases. Eating habits play an important role in defining risk trajectories in the workplace.Methods: We randomly and cross-sectionally evaluated 147 females, of which 59 were healthcare workers (HCWs) and 88 were non-HCWs. The assessment included a dietary screening for adherence to the Mediterranean diet (MD) and a clinical baseline collection of major fluid biomarkers and anthropometric indicators for cardiovascular and metabolic risk.Results: The HCW group exhibited greater adherence to the MD than the non-HCW group. Nevertheless, they showed higher serum levels of triglycerides and total cholesterol. Menopause and type of work significantly and unfavorably affected triglyceride serum levels among HCWs.Conclusion: Greater preventive efforts are needed in the context of periodic health surveillance by occupational physicians. Disseminating additional information on a healthier lifestyle, particularly among female workers of perimenopausal age, is a key issue.
The Relationship Between Storey of Buildings and Fall Risk
Authors: Tsai Ching-Yao , Lin En-Sheng , Li Yang-Tzu , Tung Tao-Hsin , Chen Wei-Cheng 
Published: November 2021

Purpose: This study examined the association between storey of building and fall risk in older adults' residences and residents' level of fear of falling.Methods: The National Health and Ageing Trends Study (NHATS) collected information that would provide an understanding of basic trends people aged 65 years and older. Using a longitudinal survey, the present study employed the first round of NHATS data that was collected in 2011. In the first round, 12,411 participants were enrolled, and 8,077 interviews were completed. The study sample sizes for falling and worry about falling are 6,153 and 6,142, respectively.Results: Unadjusted analysis revealed that storey of building was a risk factor for fall and worry about falling. There was a higher prevalence for fall and worry about falling when subjects lived in single storey of building compared with the subjects live in multi-storey. Logistic regression analysis showed no highly significant between storey of building and the fall/fear of falling.Conclusion: Several clinical factors independently were indicated pertaining to the fall and worry about falling in older adult's residences.
Case Report: Radioactive Holmium-166 Microspheres for the Intratumoral Treatment of a Canine Pituitary Tumor
Authors: Morsink Nino Chiron , Klaassen Nienke Johanna Maria , Meij Björn Petrus , Kirpensteijn Jolle , Grinwis Guillaume Cornelis Maria , Schaafsma Irene Afra , Hesselink Jan Willem , Nijsen Johannes Frank Wilhelmus , van Nimwegen Sebastiaan Alexander 
Published: November 2021

Introduction: In this case study, a client-owned dog with a large pituitary tumor was experimentally treated by intratumoral injection of radioactive holmium-166 microspheres (166HoMS), named 166Ho microbrachytherapy. To our knowledge, this is the first intracranial intratumoral treatment through needle injection of radioactive microspheres.Materials and Methods: A 10-year-old Jack Russell Terrier was referred to the Clinic for Companion Animal Health (Faculty of Veterinary Medicine, Utrecht University, The Netherlands) with behavioral changes, restlessness, stiff gait, and compulsive circling. MRI and CT showed a pituitary tumor with basisphenoid bone invasion and marked mass effect. The tumor measured 8.8 cm3 with a pituitary height-to-brain area (P/B) ratio of 1.86 cm−1 [pituitary height (cm) ×10/brain area (cm2)]. To reduce tumor volume and neurological signs, 166HoMS were administered in the tumor center by transsphenoidal CT-guided needle injections.Results: Two manual CT-guided injections were performed containing 0.6 ml of 166HoMS suspension in total. A total of 1097 MBq was delivered, resulting in a calculated average tumor dose of 1866 Gy. At 138 days after treatment, the tumor volume measured 5.3 cm3 with a P/B ratio of 1.41 cm−1, revealing a total tumor volume reduction of 40%. Debulking surgery was performed five months after 166HoMS treatment due to recurrent neurological signs. The patient was euthanized two weeks later at request of the owners. Histopathological analysis indicated a pituitary adenoma at time of treatment, with more malignant characteristics during debulking surgery.Conclusion: The 40% tumor volume reduction without evident severe periprocedural side effects demonstrated the feasibility of intracranial intratumoral 166HoMS treatment in this single dog.
Piezoelectricity in binary wurtzite semiconductors: a first-principles study
Authors: Zhao Ling-Xu , Liu Jian 
Published: November 2021

Abstract
Using first-principles calculations, we investigate piezoelectricity in a wide range of binary wurtzite semiconductors. We find that piezoelectricity is intimately related to the bond character, e.g. the negative longitudinal piezoelectric effect (NLPE) tends to occur in covalent compounds. We further find a universal sign rule (negative clamped-ion term and positive internal-strain term) for piezoelectricity, and the NLPE occurs as a result of the domination of the former over the latter. Moreover, there exists an inverse linear correlation between the longitudinal and transverse piezoelectric coefficients. This work may offer a simple criterion for efficient computational screening of materials exhibiting the NLPE.
EFFECT OF NUTRITIONAL COUNSELING LEALEF MEDIA ON KNOWLEDGE, SODIUM, POTASIUM INTAKE IN PATIENTS HYPERTENSION
Authors: Dwi Aprilia Dina , Jumiyati Jumiyati , Pravita Sari Ayu 
Published: November 2021

ABSTRACK
Hypertension actually is a disease that can be implified on sudden death. It's mostly caused by high blood pressure so that the risk of suffering complications is a big issue. It can be caused by many factors, one of that is high sodium and low potassium consumption as well. Based on 2015 WHO data, it shows that 1.13 billion people in the world have hypertension. Based on Riskesdas data the number of cases of hypertension in Indonesia is 63,309,620 people. In Bengkulu province In 2018 about province's health data, it was found that in 2018 the estimated number of sufferers ≥ 15 years reached 899,010 people. The highest hypertension was found in the Selebar Sub-District Puskesmas Basuki Rahmad about 7,464 .The purpose of this study determines the effect of nutritional counseling using modified leaflet media, knowledge of sodium and potassium intake in patients with hypertension in Basuki Rahmad Community Health Center in Bengkulu City in 2020.This research method is a pre-experimental research design with one group pretest and posttest term. Samples that were taken by purposive sampling of 25 people. Data collected includes pre test data first, namely knowledge, data, sodium intake, and potassium. After that post-test data, it is knowledge data about sodium and potassium consumption. Analysis of the data used is the univariate analysis and bivariate analysis.Based on the research from 25 samples given nutritional counseling, the results obtained knowledge about sodium and potassium consumption value of p-value 0,000.In the conclusion of this study is about the influence of nutritional counseling on sodium and potassium consumption that related to hypertension disease.
Application of a Patient Safety Culture in Undata Palu Hospital
Authors: Mbaloto Freny Ravika , Salamung Niswa , Elmiyanti Ni Ketut 
Published: November 2021

Introduction: The Word Health Organization suggests that developed countries focus more on knowledge of standardized mechanisms and organizational factors that cause unsafe care for patients, such as those related to miscommunication, eg coordination, human error and the need to improve patient safety culture. Patient safety culture is a major and fundamental factor because building a patient safety culture is a way to build an overall patient safety program. This study aims to determine the applicationof patients safety culture at Undata Hospital, Palu, Central Sulawesi Province, Indonesia.
Method: Using a survey questionnaire, this study explores differences in the application of of patient safety cultures in patient, critical and emergency rooms. The research samples of 157 people obtained through the use of probability sampling techniques. Data were analyzed using Fisher's exact test. The statistic show that there are differences in the application of safety culture in patient, critical and emergency rooms. Because there are differences in the application of safety culture between rooms, the statistical analysis was continued with the Post Hoc Mann-Whitney test.
Results: The results showed that statistically there was no difference in the application of patient safety culture between inpatient and critical rooms because p = 0.643 (p> 0,05 ), a difference in the application of patient safety culture between in patient and emergency rooms because p = 0.011 (p <0,05), a difference in the application of patient safety culture between critical rooms and emergency rooms because p = 0.049 (p<0.05).
Correlation Knowledge and Attitude of Nurse Behaviour in Medical Waste Disposal in Inpatient Ward of The JIH Hospital Yogyakarta
Authors: Jennifa Jennifa , Sari Dwi Agustiana , Anugraheni Ertanti 
Published: November 2021

Background: In Indonesia there is an increase in the amount of medical waste. Medical waste is still not managed properly and the amount is very large.Previous studies conducted found that nurses had less behavior in disposing both medical and non-medical waste (58,3%). Hospital waste management carried out by nurses and medical personnel, must be done properly and carefully.
Method: This research was an analytic survey research with cross sectional approach. The population of this study were 150 nurses in the Inpatient Ward of JIH Hospital Yogyakarta. The sampling technique was simple random sampling, amounting to 60 people. The research instrument used questionnaire. The data analysis technique used chi-square test and logistic regression.
Result: Nurses knowledge mostly in sufficient category (55%). Nurses attitude mostly in supportive category (56,7%). Nurses behavior mostly in good category (50%). There was correlation between knowledge and medical waste behavior with significant value 0,030 (p<0,05). There was correlation between attitudes and medical waste behavior with significant value 0,019 (p<0,05).
Conclusion: There were correlations of knowledge and attitudes to the medical waste behavior on nurses in inpatient ward of JIH hospital Yogyakarta.