bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring burdening effect of Shariah knowledge on sales performance; does work experience matter? A multi-group analysis in the Islamic finance industry
Authors: Shamsudheen Shinaj Valangattil , Mahomed Ziyaad 
Published: June 2021

Purpose
This study aims to examine the burdening effect of Shariah knowledge on the sales performance of the salesforce at Islamic financial institutions (IFIs) with special reference to addressing the heterogeneous effects of work experience.

Design/methodology/approach
A total of 335 samples were collected from the sales professionals of IFIs in Malaysia using a purposive sampling technique and the empirical analysis was conducted with the measures of model fit and bootstrapping technique using partial least square structural equation modeling and multi-group analysis.

Findings
Empirical results indicate that the burdening effect of Shariah knowledge is evident among salesforce and the magnitude of the impact remains consistent across the groups of salesforces with different levels of work experience.

Practical implications
Findings suggest respective authorities of IFIs intensify capacity building for their salesforce particularly in the area of Shariah knowledge and nature of underlying Islamic contracts used in the financial products. An insignificant heterogeneous effect of work experience suggests respective authorities that the actions and policy formulations are equally important among the entire salesforce regardless of the number of years of job tenure each salesforce holds.

Originality/value
As customer awareness and knowledge may be influenced by the information transferred via the IFI employees (especially salesforce in IFIs), any information overload (i.e. additional requirement of Shariah knowledge/features) on the IFI employees may, therefore, negatively influence customer patronage and reduce IFI market share. However, the increased information expectation (i.e. Shariah knowledge/features) on IFI employees and its impact on market share along with the heterogeneous effect of work experience has not been documented before. If a burdening effect of Shariah knowledge is identified, this may be a formidable reason for the slowing growth of Islamic finance.
The quadruple and quintuple helix in innovation environments (incubators and science and technology parks)
Authors: Mineiro Andrea Ap da Costa , Assis de Souza Thais , Carvalho de Castro Cleber 
Published: June 2021

Purpose
The purpose of this paper is to investigate the literature on the representation of the quadruple and quintuple helix (QQH) in innovation environments such as incubators and science and technology parks (STPs).

Design/methodology/approach
The authors used the integrative review as a methodological approach and systematized studies regarding the main research objectives; theoretical approaches; methodology and study object; QQH representation, by identifying actor, performance and main results; and additional contributions to the QQH model.

Findings
As a result, the authors noticed a lack of standardization on the representation of the quadruple helix, but the example of associations and community centers as representatives of the civil society. The quintuple helix does not have an actor that represents the environment, but STPs foster sustainable actions, encourage the generation of green companies and stimulate sustainable practices among established companies.

Originality/value
Based on changes in the economic and social scenarios, new theoretical approaches emerge to explain the innovation process, such as the QQH. Incubators and STPs are favorable settings for interactions, according to the new models; however, there is a lack of studies addressing this topic in such environments. Hence, this study contributes to understanding the existence and performance of QQH, by showing how these new helices were identified, in addition to advancing the subject in innovation environments such as incubators and STPs.
The advertising communication effectiveness of using netizen language code-switching in Facebook ads
Authors: Kuo Ying-Feng , Hou Jian-Ren , Hsieh Yun-Hsi 
Published: June 2021

PurposeNetizens refer to citizens of the internet, and code-switching refers to the use of more than one language, style or form of expression to communicate. This study explores the advertising communication effectiveness of using netizen language code-switching in Facebook ads. Moreover, if a brand is with negative brand images, using positive brand images as a control group, this study investigates not only the advertising communication effectiveness of netizen language code-switching but also its effectiveness of remedying the negative brand images.Design/methodology/approachOnline experiments were conducted, and data were analyzed using independent sample t-test, MANOVA and ANOVA.FindingsThe results indicate that netizen language code-switching can enhance advertising communication effectiveness in Facebook ads. Furthermore, under a negative brand image, netizen language code-switching has significant effects on improving Facebook advertising communication effectiveness.Originality/valueThis study takes netizens as the research subjects to explore the advertising communication effectiveness of netizen language code-switching in Facebook ads. This study provides further insight into the effect of netizens' culture on Facebook advertising and enriches the existing literature on social media advertising, as well as expanding the application of code-switching. The results of this study provide enterprises a new perspective on the copywriting content design of Facebook ads.
Blockchain in your grocery basket: trust and traceability as a strategy
Authors: Yacoub Ghassan , Castillo Maria 
Published: June 2021

Purpose
The purpose of this paper is to gain insights and explicate how blockchain technology enables trust and traceability building from a real business use case.

Design/methodology/approach
The authors conducted a qualitative case study of a leading global French grocery retail firm that has started to integrate blockchain into their supply chain and products. Data was collected through semi-structured interviews and secondary data sources.

Findings
This paper developed a conceptual framework in unboxing the mechanism by which blockchain enables trust and explicating how information flows in a blockchain-based system compared to a traditional one in a real business application scenario through three main elements, namely, system architecture, data recovery and communication.

Originality/value
Given the upside potential of emerging technologies such as blockchain coupled with the current increasing demand for business use cases, the paper is timely in integrating the business and technological aspects of trust in formulating a firm-level blockchain strategy.
“I came, I saw, I conquered”: reflections on participating in a PhotoVoice project
Authors: Barry Jennifer , Monahan Christine , Ferguson Sharon , Lee Kelley , Kelly Ruth , Monahan Mark , Murphy Rebecca , Gibbons Patrick , Higgins Agnes 
Published: June 2021

Purpose
The purpose of this paper is to provide first-hand reflective narratives from participants of their involvement in the overall process, with particular reference to the benefits and challenges of engagement.

Design/methodology/approach
Five participants agreed to write a reflective piece of approximately 500 words on their involvement in the PhotoVoice project.

Findings
The reflective narratives in this paper demonstrate the personal and professional benefits of sustained and meaningful engagement, while challenges such as power imbalances, identity management, time and cost commitments are discussed.

Practical implications
PhotoVoice is a methodology that has the potential to democratise knowledge production and dissemination.

Originality/value
There are scant examples in the PhotoVoice literature of the inclusion of participants involvement in dissemination activities. The reflective narratives in this paper demonstrate the personal and professional benefits of sustained and meaningful engagement, while challenges such as power imbalances, identity management, time and cost commitments are discussed.
Customer–brand relationship in the era of artificial intelligence: understanding the role of chatbot marketing efforts
Authors: Cheng Yang , Jiang Hua 
Published: June 2021

Purpose
This study aims to explore the role of artificial intelligence (AI)-powered chatbot marketing efforts (CMEs) in the establishment of relationships between brands and their customers, extending the link between relationship marketing and online consumer behavioral intentions.

Design/methodology/approach
Data are collected from 1,072 customers in the USA, who used chatbot marketing activities from any of 30 brands leading their industries in messaging innovation. Structural equation modeling is used for data analysis.

Findings
Results show that interaction, information, accessibility, entertainment and customization are important CMEs components. CMEs have significant direct effects on the quality of communication with chatbot agents and indirectly affect customer–brand relationships (CBR) and customer response. In addition, the findings demonstrate that CBR mediates the association between communication quality and customer response.

Originality/value
Implications of this study can enable practitioners to understand the effects of AI on user experiences and provide a guide for the development of CMEs strategies and relationship building.
The role of digital scholarship in academic libraries, the case of university of cape coast: opportunities and challenges
Authors: Ocran Theophilus Kwamena , Afful-Arthur Paulina 
Published: June 2021

PurposeThe purpose of the study is to assess the role of academic libraries in digital scholarship at the University of Cape Coast. The study adopted the descriptive survey design and used teaching staff (lecturers) as the population of the study.Design/methodology/approachA sample size of 278 was used for the study. The study used questionnaires to obtain data from participants. The study revealed that faculty members appreciate digital scholarship through the services offered by Sam Jonah Library are relevant to the current higher education context, reliable information, preservation of information resources and facilitating the integration of library services into the learning process are closely integrated into the library service, transform scholarly communication, teaching and learning style and research paradigm.FindingsThe study revealed that digital scholarship contributes to faculty members' delivery at the University of Cape Coast through the provision of information literacy training for new students, provision of reference lists of materials available in the library and provision of lists of new materials. The study revealed that faculty members face inadequate facilities to enhance digital scholarship, inadequate open access to reading materials (articles, books, etc.), inadequate platforms or suite of tools for librarians to take faculty.Practical implicationsThe application of digital scholarship provides an expansion to the core competitiveness of librarians new services which enables innovativeness and transformation of libraries. Students will be equipped with digital literacy skills; it affords instructors to approach teaching with innovation and scholars are also engaged to perform novel practices in scholarship acquisition. Digital scholarship is the umbrella under which all academic technologies comes under to foster collaboration and better learning experience.Originality/valueThis paper offers an insight of the role digital scholarship in promoting and advancing scholarship in the academic environment. It highlights a number of digital scholarship platform available in the library. It is observed that digital scholarship practices must be encouraged in the library because it facilitates the role of academic library which is to support teaching, learning and research.
Social media communication of the scientific and technological literature in emergency under COVID-19
Authors: Li Jiapei , Sun Liming , Feng Xin , He Peiyi , Zhang Yue 
Published: June 2021

PurposeThis paper takes the current COVID-19 pandemic raging around the world as a realistic background and uses the informal scientific communication mode in social media as the theoretical basis. It aims to explore the characteristics and rules of scientific communication in social media under emergency events, grasp the potential and risks of scientific communication in social media in special times and provide a perspective of academic communication for the scientific response.Design/methodology/approachThe authors select the enumeration data of the early COVID-19 theme papers spread on social media networks as the research object, apply descriptive statistical analysis to the basic statistical distribution of variables and use factor analysis and visualization methods to explore the law and characteristics of the spread of scientific papers on social media platforms.FindingsIt was found that users of the COVID-19 paper are mainly in North America, Europe and South America, followed by those in East Asia, Southeast Asia and Oceania. The users are mainly public figures, doctors and other practitioners, science communicators and scientists. The process of social media communication reflects three ways of knowledge construction, social interaction and academic communication, and there are three ways of communication law and changing trend of cross transition and integration.Originality/valueThis study observes the function and role of science communication in social media in a special period from a unique perspective of academic communication, so as to promote academic means to fight against the epidemic.
The impact of artificial intelligence and machine learning on the global economy and its implications for the hospitality sector in India
Authors: Bhushan Sudhanshu 
Published: June 2021

Purpose
The purpose of this paper is to explore and evaluate the existing and future impact of artificial intelligence (AI) and machine learning on the global economy. It includes viewing the inclusion of AI in different sectors, its impact on industries, the trends of the forerunning companies that are capitalizing on AI and the idea of crystalizing exponential growth while maintaining a balance between the understanding of humans and the subsequent possibilities of AI.

Design/methodology/approach
This paper is based on secondary research, reviewing literature based on different industries and perspectives.

Findings
The global potential of AI is exponential; the development of AI should be effective. Globally, we see contrasting views, defining the consequences of AI. Hence, the balance between humans and AI, protocols and a global regulatory system needs to be established to prevent catastrophic results soon.

Practical implications
The benefits of AI are enormous. The rising incorporation of AI must take into consideration the basic safety fundamentals for a better future.

Social implications
This paper will enable readers to understand the importance of AI in the global economy, its current involvement in major industries and the subsequent need for balance in technology.

Originality/value
This conceptual review is by its nature and original contribution and, specifically, an interpretation for India.
Bacterial cell wall‐degrading enzymes induce basidiomycete natural product biosynthesis
Authors: Herkersdorf Sebastian , Krüger Thomas , Wein Philipp , Löffler Susanne , Fontaine Thierry , Gressler Markus , Hertweck Christian , Brakhage Axel A. , Hoffmeister Dirk 
Published: June 2021

SummaryNatural products play a vital role for intermicrobial interactions. In the basidiomycete arena an important representative is variegatic acid, a lactone natural product pigment whose ecological relevance stems from both inhibiting bacterial swarming and from indirect participation in breakdown of organic matter by brown‐rotting fungi. Previous work showed that the presence of bacteria stimulates variegatic acid production. However, the actual external molecular trigger that prompts its biosynthesis in the mushroom hyphae remained unknown. Here, we report on the identification of Bacillus subtilis subtilisin E (AprE) and chitosanase (Csn) as primary inducers of pulvinic acid pigment formation. Using the established co‐culture system of B. subtilis and Serpula lacrymans, we used activity‐guided FPLC‐based fractionation of B. subtilis culture supernatants and subsequent peptide fingerprinting to identify candidates, and their role was corroborated by means of a pigment production assay using heterologously produced chitosanase and subtilisin. B. subtilis mutants defective in either the aprE or the csn gene still triggered pigmentation, yet to a lower degree, which points to a multicausal scenario and suggests the combined activity of these cell wall polymer‐attacking enzymes as true stimulus.
Unintended consequences: The impact of airway management modifications introduced in response to COVID‐19 on intubations in a tertiary centre emergency department
Authors: Groombridge Christopher J , Maini Amit , Olaussen Alexander , Kim Yesul , Fitzgerald Mark , Smit De Villiers 
Published: June 2021

AbstractObjectiveIn response to COVID‐19, we introduced and examined the effect of a raft of modifications to standard practice on adverse events and first‐attempt success (FAS) associated with ED intubation.MethodsAn analysis of prospectively collected registry data of all ED intubations over a 3‐year period at an Australian Major Trauma Centre. During the first 6 months of the COVID‐19 pandemic in Australia, we introduced modifications to standard practice to reduce the risk to staff including: aerosolisation reduction, comprehensive personal protective equipment for all intubations, regular low fidelity simulation with ‘sign‐off’ for all medical and nursing staff, senior clinician laryngoscopist and the introduction of pre‐drawn medications.ResultsThere were 783 patients, 136 in the COVID‐19 era and 647 in the pre‐COVID‐19 comparator group. The rate of hypoxia was higher during the COVID‐19 era compared to pre‐COVID‐19 (18.4% vs 9.6%, P < 0.005). This occurred despite the FAS rate remaining very high (95.6% vs 93.8%, P = 0.42) and intubation being undertaken by more senior laryngoscopists (consultant 55.9% during COVID‐19 vs 22.6% pre‐COVID‐19, P < 0.001). Other adverse events were similar before and during COVID‐19 (hypotension 12.5% vs 7.9%, P = 0.082; bradycardia 1.5% vs 0.5%, P = 0.21). Video laryngoscopy was more likely to be used during COVID‐19 (95.6% vs 82.5%, P < 0.001) and induction of anaesthesia more often used ketamine (66.9% vs 42.3%, P < 0.001) and rocuronium (86.8% vs 52.1%, P < 0.001).ConclusionsThis raft of modifications to ED intubation was associated with significant increase in hypoxia despite a very high FAS rate and more senior first laryngoscopist.
Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models
Authors: Shiraishi Ryo , Kawauchi Daisuke 
Published: June 2021

AbstractMedulloblastoma is the most common malignant cerebellar tumor in children. Recent technological advances in multilayered ’omics data analysis have revealed 4 molecular subgroups of medulloblastoma (Wingless/int, Sonic hedgehog, Group3, and Group4). (Epi)genomic and transcriptomic profiling on human primary medulloblastomas has shown distinct oncogenic drivers and cellular origin(s) across the subgroups. Despite tremendous efforts to identify the molecular signals driving tumorigenesis, few of the identified targets were druggable; therefore, a further understanding of the etiology of tumors is required to establish effective molecular‐targeted therapies. Chromatin regulators are frequently mutated in medulloblastoma, prompting us to investigate epigenetic changes and the accompanying activation of oncogenic signaling during tumorigenesis. For this purpose, we have used germline and non‐germline genetically engineered mice to model human medulloblastoma and to conduct useful, molecularly targeted, preclinical studies. This review discusses the biological implications of chromatin regulator mutations during medulloblastoma pathogenesis, based on recent in vivo animal studies.
Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
Authors: Toriyama Kazutoshi , Takano Naoharu , Kokuba Hiroko , Kazama Hiromi , Moriya Shota , Hiramoto Masaki , Abe Shinji , Miyazawa Keisuke 
Published: June 2021

AbstractCancer cells use autophagy for growth, survival, and cytoprotection from chemotherapy. Therefore, autophagy inhibitors appear to be good candidates for cancer treatment. Our group previously reported that macrolide antibiotics, especially azithromycin (AZM), have potent autophagy inhibitory effects, and combination treatment with tyrosine kinase inhibitors or proteasome inhibitors enhances their anti–cancer activity. In this study, we evaluated the effect of combination therapy with DNA‐damaging drugs and AZM in non–small‐cell lung cancer (NSCLC) cells. We found that the cytotoxic activities of DNA‐damaging drugs, such as doxorubicin (DOX), etoposide, and carboplatin, were enhanced in the presence of AZM in NSCLC cell lines, whereas AZM alone exhibited almost no cytotoxicity. This enhanced cell death was dependent on wild‐type‐p53 status and autophagosome‐forming ability because TP53 knockout (KO) and ATG5‐KO cells attenuated AZM‐enhanced cytotoxicity. DOX treatment upregulated lysosomal biogenesis by activating TFEB and led to lysosomal membrane damage as assessed by galectin 3 puncta assay and cytoplasmic leakage of lysosomal enzymes. In contrast, AZM treatment blocked autophagy, which resulted in the accumulation of lysosomes/autolysosomes. Thus, the effects of DOX and AZM were integrated into the marked increase in damaged lysosomes/autolysosomes, leading to prominent lysosomal membrane permeabilization (LMP) for apoptosis induction. Our data suggest that concomitant treatment with DNA‐damaging drugs and AZM is a promising strategy for NSCLC treatment via pronounced LMP induction.
CAR‐NK cell in cancer immunotherapy; A promising frontier
Authors: Marofi Faroogh , Abdul‐Rasheed Omar F. , Rahman Heshu Sulaiman , Budi Hendrik Setia , Jalil Abduladheem Turki , Yumashev Alexei Valerievich , Hassanzadeh Ali , Yazdanifar Mahboubeh , Motavalli Roza , Chartrand Max Stanley , Ahmadi Majid , Cid‐Arreguid Angel , Jarahian Mostafa 
Published: June 2021

AbstractChimeric antigen receptors (CARs) have a unique facet of synthetic biology and offer a paradigm shift in personalized medicine as they can use and redirect the patient's immune cells to attack cancer cells. CAR‐natural killer (NK) cells combine the targeted specificity of antigens with the subsequent intracellular signaling ability of the receptors to increase their anti‐cancer functions. Importantly, CAR‐NK cells can be utilized as universal cell‐based therapy without requiring human leukocyte antigen (HLA) matching or earlier contact with tumor‐associated antigens (TAAs). Indeed, CAR‐NK cells can be adapted to recognize various antigens, hold higher proliferation capacity, and in vivo persistence, show improved infiltration into the tumors, and the ability to overcome the resistant tumor microenvironment leading to sustained cytotoxicity against tumors. Accumulating evidence from recent in vivo studies rendering CAR‐NK cell anti‐cancer competencies renewed the attention in the context of cancer immunotherapy, as these redirected effector cells can be used in the development of the “off‐the‐shelf” anti‐cancer immunotherapeutic products. In the current review, we focus on the therapeutic efficacy of CAR‐NK cell therapies for treating various human malignancies, including hematological malignancies and solid tumors, and will discuss the recent findings in this regard, with a special focus on animal studies.