bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case for Electron-Astrophysics
Authors: Verscharen Daniel , Wicks Robert T. , Alexandrova Olga , Bruno Roberto , Burgess David , Chen Christopher H. K. , D’Amicis Raffaella , De Keyser Johan , de Wit Thierry Dudok , Franci Luca , He Jiansen , Henri Pierre , Kasahara Satoshi , Khotyaintsev Yuri , Klein Kristopher G. , Lavraud Benoit , Maruca Bennett A. , Maksimovic Milan , Plaschke Ferdinand , Poedts Stefaan , Reynolds Christopher S. , Roberts Owen , Sahraoui Fouad , Saito Shinji , Salem Chadi S. , Saur Joachim , Servidio Sergio , Stawarz Julia E. , Štverák Štěpán , Told Daniel 
Published: June 2021

AbstractThe smallest characteristic scales, at which electron dynamics determines the plasma behaviour, are the next frontier in space and astrophysical plasma research. The analysis of astrophysical processes at these scales lies at the heart of the research theme of electron-astrophysics. Electron scales are the ultimate bottleneck for dissipation of plasma turbulence, which is a fundamental process not understood in the electron-kinetic regime. In addition, plasma electrons often play an important role for the spatial transfer of thermal energy due to the high heat flux associated with their velocity distribution. The regulation of this electron heat flux is likewise not understood. By focussing on these and other fundamental electron processes, the research theme of electron-astrophysics links outstanding science questions of great importance to the fields of space physics, astrophysics, and laboratory plasma physics. In this White Paper, submitted to ESA in response to the Voyage 2050 call, we review a selection of these outstanding questions, discuss their importance, and present a roadmap for answering them through novel space-mission concepts.
Implementation, relevance, and virtual adaptation of neuro-oncological tumor boards during the COVID-19 pandemic: a nationwide provider survey
Authors: Schäfer Niklas , Bumes Elisabeth , Eberle Fabian , Fox Viola , Gessler Florian , Giordano Frank A. , Konczalla Juergen , Onken Julia , Ottenhausen Malte , Scherer Moritz , Schneider Matthias , Vatter Hartmut , Herrlinger Ulrich , Schuss Patrick 
Published: June 2021

Abstract
Purpose
Neuro-oncology tumor boards (NTBs) hold an established function in cancer care as multidisciplinary tumor boards. However, NTBs predominantly exist at academic and/or specialized centers. In addition to increasing centralization throughout the healthcare system, changes due to the COVID-19 pandemic have arguably resulted in advantages by conducting clinical meetings virtually. We therefore asked about the experience and acceptance of (virtualized) NTBs and their potential benefits.

Methods
A survey questionnaire was developed and distributed via a web-based platform. Specialized neuro-oncological centers in Germany were identified based on the number of brain tumor cases treated in the respective institution per year. Only one representative per center was invited to participate in the survey. Questions targeted the structure/organization of NTBs as well as changes due to the COVID-19 pandemic.

Results
A total of 65/97 institutions participated in the survey (response rate 67%). In the context of the COVID-19 pandemic, regular conventions of NTBs were maintained by the respective centers and multi-specialty participation remained high. NTBs were considered valuable by respondents in achieving the most optimal therapy for the affected patient and in maintaining/encouraging interdisciplinary debate/exchange. The settings of NTBs have been adapted during the pandemic with the increased use of virtual technology. Virtual NTBs were found to be beneficial, yet administrative support is lacking in some places.

Conclusions
Virtual implementation of NTBs was feasible and accepted in the centers surveyed. Therefore, successful implementation offers new avenues and may be pursued for networking between centers, thereby increasing coverage of neuro-oncology care.
Impacts of highly automated vehicles on travel demand: macroscopic modeling methods and some results
Authors: Sonnleitner Jörg , Friedrich Markus , Richter Emely 
Published: June 2021

AbstractAutomated vehicles (AV) will change transport supply and influence travel demand. To evaluate those changes, existing travel demand models need to be extended. This paper presents ways of integrating characteristics of AV into traditional macroscopic travel demand models based on the four-step algorithm. It discusses two model extensions. The first extension allows incorporating impacts of AV on traffic flow performance by assigning specific passenger car unit factors that depend on roadway type and the capabilities of the vehicles. The second extension enables travel demand models to calculate demand changes caused by a different perception of travel time as the active driving time is reduced. The presented methods are applied to a use case of a regional macroscopic travel demand model. The basic assumption is that AV are considered highly but not fully automated and still require a driver for parts of the trip. Model results indicate that first-generation AV, probably being rather cautious, may decrease traffic performance. Further developed AV will improve performance on some parts of the network. Together with a reduction in active driving time, cars will become even more attractive, resulting in a modal shift towards car. Both circumstances lead to an increase in time spent and distance traveled.
Investigation of Two Immiscible Liquids Wetting at Elevated Temperature: Interaction Between Liquid FeMn Alloy and Liquid Slag
Authors: Bao Sarina , Tangstad Merete , Tang Kai , Einarsrud Kristian Etienne , Syvertsen Martin , Onsøien Morten , Kudyba Artur , Bublik Sergey 
Published: June 2021

Abstract
The goal of the current work is to develop a methodology to study the wetting behaviour of two immiscible liquids at high temperatures, and to investigate the parameters which influence the wetting properties. The wetting behaviour between synthetic FeMn alloy and synthetic slag has been investigated using the sessile drop technique. Two experimental procedures were implemented under both Ar and CO atmospheres: (a) FeMn alloy and slag placed next to each other on a graphite substrate; and (b) one droplet dropped on top of the other. FactSage is applied to calculate reactions and their equilibrium. The current work presents and demonstrates the suggested methodologies. The results indicate that the wetting between slag and FeMn alloy is relatively stable at temperatures up to 100 K above their melting points, regardless of the droplet size and atmosphere. MnO reduction is accelerated at higher temperature, especially in CO, thus increasing the wetting between FeMn alloy and slag, eventually fusing together. At even higher temperature, slag separates from FeMn alloy due to changing chemical composition during non-equilibrium MnO reduction.
Neurological disease caused by Oropouche virus in northern Brazil: should it be included in the scope of clinical neurological diseases?
Authors: Chiang Jannifer O. , Azevedo Rafael S. , Justino Maria C. A. , Matos Haroldo J. , Cabeça Hideraldo L. S. , Silva Sandro P. , Henriques Daniele F. , Silva Eliana V. P. , Andrade Gabriela S. S. , Vasconcelos Pedro FC. , Martins Lívia C. , Azevedo Raimunda S. S. 
Published: June 2021

AbstractWe describe two neurological cases of Oropouche virus infection in northern Brazil, where the virus is endemic but neglected as a pathogen. This study reiterates the necessity of developing protocols for diagnosing infections and training medical personnel to recognize the pathogenicity of Oropouche virus in neurological infections.
The Pattern of Help-Seeking Behavior Among Patients With Sexual Dysfunctions Attending in Psychiatry Outpatient Department in a Tertiary Care Hospital of Bangladesh
Authors: Acharjee Panchanan , Mullick Mohammad Sayadul Islam 
Published: June 2021

Abstract

Introduction
Identifying the possible pattern of help-seeking can explain the gap between care need and actual use of care.

Aim
To know the patterns of help-seeking behavior among patients with sexual dysfunction in the context of a developing country.

Methods
This was a cross-sectional, qualitative study using criterion sampling among the diagnosed patients of sexual dysfunction attending the psychiatry outpatient department. Based on data saturation, 18 in-depth interviews were done. For method triangulation, 1 key informant interview, 1 informal interview, and 1 focus group discussion were performed. Data were analyzed manually using the thematic analysis method.

Main Outcome Measure
Using an interview guideline, face to face interview was performed and the participants reported their pattern of help-seeking regarding their sexual problems.

Results
The majority of the participants were male, within 20–35 years of age range, literate, and from an urban background. Premature ejaculation and female sexual interest/arousal disorder were the most common disorders. After the identification of the problems, help-seeking was done mostly from close and intimate relationships, although a few of the participants choose a self-search strategy. The complementary and alternative medicine approach was mostly used where traditional healers played a major role. The biomedical approach was the last to seek help and most of the participants visited the dermatology and venereology department. Self-help techniques and internet use were found as emerging ways to seek help.

Conclusion
Sex education is necessary to improve general awareness because surrounding people were found as the primary source of information. Acharjee P, Mullick MSI. The Pattern of Help-Seeking Behavior Among Patients With Sexual Dysfunctions Attending in Psychiatry Outpatient Department in a Tertiary Care Hospital of Bangladesh. Sex Med 2021;9:100381.
Trust and Public Health Emergency Events: A Mixed-Methods Systematic Review
Authors: Sopory Pradeep , Novak Julie M. , Day Ashleigh M. , Eckert Stine , Wilkins Lee , Padgett Donyale R. , Noyes Jane P. , Allen Tomas , Alexander Nyka , Vanderford Marsha L. , Gamhewage Gaya M. 
Published: June 2021

AbstractThe systematic review examined the phenomenon of trust during public health emergency events. The literature reviewed was field studies done with people directly affected or likely to be affected by such events and included quantitative, qualitative, mixed-method, and case study primary studies in English (N= 38) as well as Arabic, Chinese, French, Russian, and Spanish (all non-EnglishN= 30). Studies were mostly from high- and middle-income countries, and the event most covered was infectious disease. Findings from individual studies were first synthesized within methods and evaluated for certainty/confidence, and then synthesized across methods. The final set of 11 findings synthesized across methods identified a set of activities for enhancing trust and showed that it is a multi-faceted and dynamic concept.
Effects of Ventenata dubia removal on rangelands of northeast Wyoming
Authors: Hart Marshall , Mealor Brian A. 
Published: June 2021

AbstractVentenata [Ventenata dubia (Leers) Coss.] is one of several annual grass invaders of the western United States. Ventenata dubia is documented reducing the forage availability for livestock and wildlife as well as lowering biodiversity in the Great Basin. This species has recently spread to the Great Plains, where it could bring these impacts with it. We attempt to answer questions on whether or not conservation practices, in this case removal of V. dubia with herbicide, result in recovery of forage resources and biodiversity. We answer these questions by measuring biomass, cover, and nutrient content 1-yr posttreatment at 9 sites in Sheridan County, WY, conducted in two years. Perennial grasses have higher crude protein and total digestible nutrients than V. dubia, and removal of V. dubia resulted in a positive perennial grass response both years. Further, the differences in pattern of growth between perennial and annual species, with annual grasses quickly senescing early in the year, make perennial grasses a more dependable forage base with higher available nutrients. Interestingly, total biomass and nutrient mass did not change after V. dubia removal due to equal replacement with perennial grasses. Species richness and diversity were unaffected by removal of V. dubia. Our results suggest that managing invasive annual grasses, particularly V. dubia, in the Northern Great Plains can improve forage resources for livestock and wildlife while maintaining species diversity. Therefore, proactive monitoring and management efforts to prevent spread should be prioritized in this region.
Comprehension of complex sentences with misleading cues in monolingual and bilingual children
Authors: Ostadghafour Sarvenaz , Bialystok Ellen 
Published: June 2021

AbstractBilingual children typically perform more poorly than monolingual children on linguistic tasks but better than monolingual children on cognitive tasks requiring executive function. The present study examined performance on complex linguistic tasks that also required executive functioning for their solution. One hundred 4-year-olds from linguistically diverse backgrounds (36 monolinguals, 64 bilinguals) performed two linguistic tasks in which misleading information needed to be ignored to select the correct answer. Data were analyzed both categorically by comparing the performance of children assigned to monolingual and bilingual groups and continuously in terms of degree of bilingual experience across the entire sample. In the categorical analyses, bilingual children were more accurate than monolingual children in understanding the meaning of spoken sentences in the presence of distraction in both tasks, and continuous analyses showed that performance was calibrated to degree of bilingualism in one of the tasks, with higher levels of bilingualism being associated with better performance. The interpretation is that attentional control built up through bilingual experience compensates for lower levels of language proficiency in performing these complex linguistic tasks. The study also endorses the use of continuous assessments of bilingualism rather than categorical assignment to groups to obtain more nuanced results.
Post-operative course of pulmonary artery pressure after complete atrioventricular canal defect repair
Authors: Pierre Louis Marie Emeline , Bhutta Adnan , Holloway Adrian , Gaskin Peter 
Published: June 2021

AbstractComplete atrioventricular canal defect is a CHD associated with intra-cardiac shunting of blood, which can lead to irreversible changes in pulmonary vascular resistance and pulmonary artery hypertension if unrepaired. Patients with Trisomy 21 are at risk for early development of pulmonary artery hypertension if left uncorrected.1,2Objectives:The purpose of this study is to describe the evolution of pulmonary artery hypertension after repair of complete atrioventricular canal defect and to determine the time to normalisation of pulmonary artery pressure in both patients with and without Trisomy 21.Methods:This is a single centre, retrospective analysis of patients with complete atrioventricular canal defect admitted for surgical repair at the University of Maryland Medical Center from 2005 to 2015. T-test or Mann–Whitney test and Chi-Square or Fisher’s exact tests were used to compare the two groups (patients with Trisomy 21 and those without). Repeated measures of analysis of variance and serial measurement analysis were performed.Results:Twenty-nine patients meeting the inclusion criteria underwent repair of complete atrioventricular defects during the study period. The right ventricular pressure estimate remained elevated over time and did not show a significant difference between the two groups. Right ventricular to systolic blood pressure ratios for all patients remained > 0.5 over the time periods assessed.Conclusions:Our study suggests that in patients with complete atrioventricular canal defects, the right ventricular pressure remains elevated and does not normalise on echocardiograms performed up to one year after surgery, suggesting a sustained elevation in pulmonary vascular resistance.
Ku/Ka band diplexer based on thin-film technology for small ground-segment user terminals
Authors: Moscato Stefano , Cannone Giandomenico , Oldoni Matteo , Tiradossi Davide , Pelliccia Luca , Jankovic Petar , De Paolis Fabrizio 
Published: June 2021

AbstractThis paper describes the outcome of the “Small user TErminal multi band DIplexer” project where the goal is the validation of novel SMD-compliant planar diplexer. The real application scenario concerns an integrated multi-band radio terminal for ground-segment satellite links. The advantageous and novel approach involves the simultaneous use of three different well-established concepts: a microstrip low-pass filter, a substrate integrated waveguide high-pass filter, and the thin-film technology as manufacturing process. The proposed topology applied to a planar alumina-based design guarantees a 15 × 11.1 mm2 footprint and the best integration with surface mountable soldering process over standard PCB technology. Achieved performance and resilience to environmental toughness are suitable for consumer-oriented satellite links or man-pack applications. The designed component targets the Ku 10.7–12.75 (RX) and Ka 27.5–30 (TX) GHz bands but the layout can be easily tuned across the spectrum. The described solution has been manufactured and validated. Thermal cycling and mechanical tests have been carried out to prove the high technology readiness level of the proposed device.
Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty
Authors: Ho Tiffany C. , Gifuni Anthony J. , Gotlib Ian H. 
Published: June 2021

AbstractSuicide is the second leading cause of death among adolescents. While clinicians and researchers have begun to recognize the importance of considering multidimensional factors in understanding risk for suicidal thoughts and behaviors (STBs) during this developmental period, the role of puberty has been largely ignored. In this review, we contend that the hormonal events that occur during puberty have significant effects on the organization and development of brain systems implicated in the regulation of social stressors, including amygdala, hippocampus, striatum, medial prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex. Guided by previous experimental work in adults, we also propose that the influence of pubertal hormones and social stressors on neural systems related to risk for STBs is especially critical to consider in adolescents with a neurobiological sensitivity to hormonal changes. Furthermore, facets of the pubertal transition, such as pubertal timing, warrant deeper investigation and may help us gain a more comprehensive understanding of sex differences in the neurobiological and psychosocial mechanisms underlying adolescent STBs. Ultimately, advancing our understanding of the pubertal processes that contribute to suicide risk will improve early detection and facilitate the development of more effective, sex-specific, psychiatric interventions for adolescents.
The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers
Authors: Kimura Hirokazu , Sada Ryota , Takada Naoki , Harada Akikazu , Doki Yuichiro , Eguchi Hidetoshi , Yamamoto Hideki , Kikuchi Akira 
Published: June 2021

AbstractDickkopf1 (DKK1) is overexpressed in various cancers and promotes cancer cell proliferation by binding to cytoskeleton-associated protein 4 (CKAP4). However, the mechanisms underlying DKK1 expression are poorly understood. RNA sequence analysis revealed that expression of the transcription factor forkhead box M1 (FOXM1) and its target genes concordantly fluctuated with expression of DKK1 in pancreatic ductal adenocarcinoma (PDAC) cells. DKK1 knockdown decreased FOXM1 expression and vice versa in PDAC and esophageal squamous cell carcinoma (ESCC) cells. Inhibition of either the DKK1-CKAP4-AKT pathway or the ERK pathway suppressed FOXM1 expression, and simultaneous inhibition of both pathways showed synergistic effects. A FOXM1 binding site was identified in the 5ʹ-untranslated region of the DKK1 gene, and its depletion decreased DKK1 expression and cancer cell proliferation. Clinicopathological and database analysis revealed that PDAC and ESCC patients who simultaneously express DKK1 and FOXM1 have a poorer prognosis. Multivariate analysis demonstrated that expression of both DKK1 and FOXM1 is the independent prognostic factor in ESCC patients. Although it has been reported that FOXM1 enhances Wnt signaling, FOXM1 induced DKK1 expression independently of Wnt signaling in PDAC and ESCC cells. These results suggest that DKK1 and FOXM1 create a positive feedback loop to promote cancer cell proliferation.
IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform
Authors: Harama Daisuke , Yahata Takashi , Kagami Keiko , Abe Masako , Ando Norie , Kasai Shin , Tamai Minori , Akahane Koshi , Inukai Takeshi , Kiyokawa Nobutaka , Ibrahim Abd Aziz , Ando Kiyoshi , Sugita Kanji 
Published: June 2021

AbstractThe long-term prognosis of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) is still unsatisfactory even after the emergence of tyrosine kinase inhibitors (TKIs) against chimeric BCR-ABL, and this is associated with the high incidence of genetic alterations of Ikaros family zinc finger 1 (IKZF1), most frequently the hemi-allelic loss of exons 4–7 expressing a dominant-negative isoform Ik6. We found that lenalidomide (LEN), a representative of immunomodulatory drugs (IMiDs), which have been long used for the treatment of multiple myeloma, specifically induced accumulation of Ik6 with the disappearance of functional isoforms within 24 h (i.e., abrupt and complete shut-down of the IKZF1 activity) in Ik6-positive Ph+ALL cells in a neddylation-dependent manner. The functional IKZF3 isoforms expression was also abruptly and markedly downregulated. The LEN treatment specifically suppressed proliferation of Ik6-positive-Ph+ALL cells by inducing cell cycle arrest via downregulation of cyclins D3 and E and CDK2, and of importance, markedly upregulated their apoptosis in synergy with the TKI imatinib (IM). Apoptosis of IM-resistant Ph+ALL cells with T315I mutation of BCR-ABL was also upregulated by LEN in the presence of the newly developed TKI ponatinib. Analyses of flow cytometry, western blot, and oligonucleotide array revealed that apoptosis was caspase-/p53-dependent and associated with upregulation of pro-apoptotic Bax/Bim, enhanced dephosphorylation of BCR-ABL/Akt, and downregulation of oncogenic helicase genes HILLS, CDC6, and MCMs4 and 8. Further, the synergism of LEN with IM was clearly documented as a significant prolongation of survival in the xenograft mice model. Because this synergism was further potentiated in vitro by dexamethasone, a key drug for ALL treatment, the strategy of repositioning IMiDs for the treatment of Ik6-positive Ph+ALL patients certainly shed new light on an outpatient-based treatment option for achieving their long-term durable remission and higher QOL, particularly for those who are not tolerable to intensified therapeutic approaches.