bluuebunny/crossref_metadata_2025_split huggingface dataset:
A model of qardhul hassan for university staff in Malaysia
Authors: Amin Hanudin , Panggi Faizah 
Published: January 2025

PurposeThis study investigated drivers that explain qardhul hassan financing acceptance in Malaysia involving staff of two universities namely A in East Malaysia and B in West Malaysia.Design/methodology/approachThe attitude-social influence-self-efficacy (ASE) model was tested to examine 422 respondents’ acceptance using SPSS 27.FindingsThe study confirmed the significance of all tested hypotheses, with attitude playing a key mediating role. Further, this study uncovered significant results of relative advantage and Islamic debt collection policy, offering novel contributions to this discipline.Research limitations/implicationsThe generalisation of the findings generated was limited to the context concerned and the limited variables tested.Practical implications The results offer a directive for universities to offer qardhul hassan in the future to attract demand and acceptance.Originality/valueThis study introduced a modified ASE called the QH-ASE framework to analyse its adoption, adaptability and impact on qardhul hassan financing usefulness.
Misinformation detection: datasets, models and performance
Authors: Chung Hsin-Hsuan , Chen Jiangping 
Published: January 2025

PurposeThis paper aims to understand the characteristics of current misinformation detection studies, including the datasets used by researchers, the computational models or algorithms being developed or applied, and the performance of misinformation detection models or algorithms.Design/methodology/approachWe first identified articles from the Scopus database with inclusion and exclusion criteria. Then a coding scheme was derived from the articles based on research questions. Next, datasets, models, and performance were coded. The paper concluded with answers to research questions and future research directions.FindingsFrom 115 relevant articles published during 2019–2023 on misinformation detection. We found that most studies used previously existing datasets. Twitter (now X) has been the most widely used source for collecting social media misinformation data. The ten most frequently used datasets are identified. Most studies (96.1%) developed or applied machine learning, especially deep learning models. The most advanced current misinformation detection models could achieve pretty high performance. For example, among 104 studies reporting performance with accuracy, 44.2% achieved an accuracy of 0.95 or higher, and 24.0% achieved 0.90–0.94 on accuracy.Research limitations/implicationsOur study only reviewed English articles from 2019–2023 that are included in the Scopus database. Articles that are not included in the Scopus database are not reviewed.Practical implicationsThe high performance of misinformation detection indicates that social media should be able to detect most misinformation if they are willing to do it. However, no system or algorithm could achieve 100% misinformation on performance. Due to the complexity of misinformation, users of social media still need to improve their capabilities of evaluating information on the Internet.Social implicationsThis study provides evidence to policymakers that social media platforms have the capability of detecting most misinformation posted. These platforms are responsible for alerting to suspicious postings with misinformation.Originality/valueThis study identifies datasets, computer models, and performance of models from current misinformation detection research. The findings will help social media companies, computer scientists, and information system designers improve their misinformation detection systems. It will also help students in information science and computer science to study the latest models and algorithms. Information professionals may work with computer scientists to improve datasets used for misinformation detection.
Low relative humidity-dependent polyvinyl butyral film dosimeter containing 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide dye for radiation processing
Authors: Rabaeh Khalid , Basfar Ahmed A. , Hammoudeh Issra’ M.E. 
Published: January 2025

Purpose
This study aims to develop a film dosimeter composed of 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MMT) dye and polyvinyl butyral (PVB) binder to reduce the effect if relative humidity effect during irradiation.

Design/methodology/approach
The films were exposed to gamma ray radiation from a 60Co gamma ray source with 8.6 kGy/h dose-rate and 1.25 MeV beam energy to various doses ranging from 2.5 to 100 kGy. UV-VIS spectrophotometer was used to measure the changes in optical properties of irradiated films by means of the changes in the absorbance values at wavelength of 560 nm.

Findings
The effect of irradiation temperature, relative humidity, fluorescent light and postirradiation stability on the performance of developed film dosimeter were investigated.

Practical implications
Previous MMT dye with PVA binder was significant effect of the relative humidity on the dose response of MMT-PVA films which decrease the practical feasibility of using these films in routine high-dose measurements. Therefore, the purpose of this study is to reduce the relative humidity effect on the dose response by proposing a formula for film dosimeters that combines MMT dye with the polyvinyl butyral (PVB) binder.

Originality/value
The irradiation of MMT-PVB films leads to a change in color from yellow to brown, which could be evaluated by the absorbance intensity.
Contrasting ecological mechanisms mediate the impact of land conversion on ecosystem multifunctionality
Authors: Noulèkoun Florent , Mensah Sylvanus , Kim HyungSub , Houndonougbo Juliano Sènanmi Hermann , Mensah Michael , Lee Woo Kyun , Son Yowhan , Khamzina Asia 
Published: January 2025

Abstract

Land use/cover (LULC) changes have unequivocally affected biodiversity and ecosystem functioning, with enormous repercussions for human well‐being. However, the mechanistic ecological mechanisms underlying the impact of land conversion on ecosystem multifunctionality (EMF) remain insufficiently examined from the perspective of multiple biodiversity attributes in dryland regions with increasing deforestation rates.

We investigated how the conversion of natural forests and savannas to agroforestry parklands alters the relationships between multiple biodiversity attributes (taxonomic, functional, phylogenetic and structural) and EMF, while accounting for the effects of environmental factors in the dryland landscapes in Benin. We used forest inventory data from 145 plots spanning forests, savannas and agroforestry parklands and assessed the implications of three land conversion scenarios. We quantified EMF using eight functions that are central to primary productivity and nutrient cycling.

We found that EMF was positively related solely to structural diversity in forests. The conversion of forests and savannas to agroforestry parklands decreased EMF both directly and indirectly. The indirect effects were mediated by two contrasting biodiversity effects. When forests were converted to agroforestry parklands through savannas, indirect effects were driven by shifts in functional composition towards the dominance of species with acquisitive traits. In contrast, species diversity reduction explained the indirect effects when savannas were converted to agroforestry parklands. The aridity index and soil texture influenced biodiversity attributes, but not EMF.

The present study provides evidence that the biodiversity–EMF relationship is dependent on the LULC type and was evident only in the natural ecosystem through the effects of structural diversity, thereby emphasizing the importance of enhancing structural diversity for promoting EMF in forests. Our findings also demonstrate that land conversion weakened natural EMF through biotic homogenization resulting from two contrasting biodiversity‐related mechanisms, including loss of species diversity and dominance of species with acquisitive resource‐use strategy.

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Glucocorticoid responses of wildlife to anthropogenic stressors are influenced by disturbance type and species traits
Authors: Mirante Davide , Santini Luca , Costantini David , Benítez‐López Ana 
Published: January 2025

Abstract

Ecological and conservation research has focused on documenting wildlife's behavioural and demographic responses to anthropogenic disturbance. Yet, a significant gap remains in our understanding of the physiological mechanisms that underlie behavioural or demographic adaptations to human activities.

Glucocorticoid concentrations (GCCs) are widely considered as relevant endpoints to assess the physiological response of wildlife to natural or anthropogenic stressors, yet recent studies show mixed outcomes concerning GCC shifts in disturbed populations. Consequently, uncertainties remain around the role of GCCs as reliable indicators of the effect of anthropogenic disturbance on organisms' physiology, likely due to the masking effect of several confounding factors.

To unveil generalizable patterns of physiological effects of human disturbance on wildlife, we collected GCCs measured in conspecific populations living in undisturbed and disturbed areas from 121 studies and 114 species of terrestrial vertebrates, and assessed the roles of disturbance type and species traits in shaping GCC shifts using a phylogenetic meta‐analysis of log response ratios (lnRRΔ).

We found a 36% increase in GCCs due to human disturbance in mammals (lnRRΔ = 0.304), but no evidence of a generalizable effect for birds, non‐avian reptiles and amphibians. Mammals showed similar responses to all forms of anthropogenic disturbance, while birds showed 24.6% increase in GCCs for habitat conversion only (lnRRΔ = 0.221). Furthermore, change in GCCs tended to be higher in large‐sized than in small‐sized mammals, but comparatively lower in herbivorous mammals. Finally, we found non‐migratory birds to elicit stronger responses compared with migratory birds (lnRRΔ = 0.234).

Our study provides novel evidence supporting the influential roles of diet and body mass in mammals, and migratory behaviours in birds, in shaping glucocorticoid responses to human disturbance, establishing a link between magnitude of physiological responses and pace‐of‐life‐related traits. Furthermore, we found GCC trends to be coherent with known demographic and behavioural responses, suggesting that GCC shifts might be costly to sustain, thus serving as potential early‐warning signals of population decline. Finally, we found consistency in the magnitude of GCC shifts in mammals facing all types of human disturbance, highlighting that even seemingly innocuous interactions with humans may still induce substantial physiological changes.

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Phillygenin Inhibits PI3K‐Akt–mTOR Signalling Pathway to Prevent bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice
Authors: Wei Yongjia , Ni Wenting , Zhao Lizhi , Gao Yanhong , Zhou Bing , Feng Qun , Ma Yun , Wang Limin 
Published: January 2025

ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterised by irreversible lung structure and function. Phillygenin (PHI) is a lignan extracted from Forsythiae fructus with the activities of anti‐inflammatory and antioxidant. This study aimed to explore the protective effect of PHI on IPF. The mouse model of IPF was established by bleomycin (BLM), and then treated with PHI. After 15 days of administration, the lung index was calculated. H&E staining, Masson staining and immunohistochemical methods were used to detect the effect of PHI on pulmonary fibrosis. MDA and SOD were tested to evaluate the effect of PHI on lung tissue oxidative stress. Western blot was used to detect the effect of PHI on the expressions of α‐SMA, p‐smad2, TGF‐ β1, Nrf2, HO‐1 and NQO‐1. Network pharmacology was used to identify the key signalling pathways for PHI to improve IPF, and Western blot was used to validate the result. The results showed that PHI prevented mice from BLM‐induced IPF, manifested by reducing lung index, improving lung tissue pathological damage, inhibiting collagen deposition and expression of fibrosis markers including α‐SMA, collagen1, p‐smad2 and TGF‐β1. PHI inhibited oxidative stress by upregulating the expressions of Nrf2, HO‐1 and NQO‐1. Network pharmacology revealed that PI3K‐Akt–mTOR signalling pathway was the underlying target of PHI for IPF. Molecular docking indicated strong binding of PHI with PIK3CA, AKT1 and RELA. Western blot validated that PHI downregulated the PI3K‐Akt–mTOR signalling pathway and stimulated autophagy. This study indicated that PHI prevented BLM‐induced pulmonary fibrosis by inhibiting PI3K‐Akt–mTOR signalling pathway.
Parent coaching behaviours in in‐person and telepractice early intervention for children with hearing loss
Authors: Tutuk Hülya Ceren , Çavuşoğlu Tezcan , Atlar Yıldırım Hilal , Gürgür Hasan 
Published: January 2025

AbstractFamily‐Centered Early Intervention (FCEI) involves developing parents' knowledge and skills through parent coaching to support the listening and language development of their children with hearing loss. The traditional delivery of parent coaching at FCEI has been in in‐person settings. With the advancement of technology, telepractice has become widespread. This has increased the diversity of service delivery, especially for children with hearing loss who face difficulty accessing a qualified interventionist. This study examined the parent coaching behaviours of an educator providing early intervention services to children with hearing loss and their parents in in‐person and telepractice settings. The research is a qualitative case study. Data were collected through observation, an interview, documents and a research diary. The results indicated that implementing feedback, modelling and guided practice varied due to challenges in engaging children during telepractice sessions. In‐person, these behaviours were applied within the activity involving both parent and child. In telepractice, feedback and modelling were limited to discussions with the parent, and guided practice was not demonstrated. The results suggest that, despite the educator's efforts to find solutions, structural limitations may have limited the support parents received from telepractice sessions compared to in‐person sessions.
Experience With Dabigatran on Rate of Portal Vein Thrombosis Recanalization, Disease Progression and Survival
Authors: Premkumar Madhumita , Bhujade Harish , Sharma Prerna , Nain Jasvinder , Ahluwalia Jasmina , Sandhu Anchal , Kumar Yogendra , Rathi Sahaj , Taneja Sunil , Duseja Ajay Kumar , Kulkarni Anand V. , Singh Charanpreet , Naseem Shano , Karki Tanka , Gupta Pankaj , Chaluvashetty Sreedhara B. , Lad Deepesh , Reddy K. Rajender 
Published: January 2025

ABSTRACTBackground and AimsWe assessed clinical, procoagulant and genetic risk factors and clinical outcomes in dabigatran‐treated patients with non‐tumoural acute and acute‐on‐chronic portal vein thrombosis (PVT).MethodsPatients with a new diagnosis of non‐tumoural acute and acute‐on‐chronic PVT between January 2021 and January 2024 (aged ≥ 18 years) in those without/with cirrhosis (Child‐Pugh (CP)‐A/B/C ≤ 10) were started on dabigatran and followed and compared with those on vitamin K antagonist (VKA) and untreated individuals.ResultsDabigatran was prescribed in 119 patients with PVT type 1 (61, 51.3%), type 2 (34, 28.6%), type 3 (24, 20.2%); 72 (60.5%) with cirrhosis [CP‐A (27, 37.5%), CP‐B (43, 59.7%) and CP‐C10 (2, 2.8%)]. Procoagulant factors noted were JAK2V617F (10.1%), CALR (2.5%) and factor V Leiden (1.6%) mutations, antiphospholipid syndrome (APS, 15.2%), isolated Protein C (14.3%) and Protein S (16.8%) deficiency. Comparators: 28 patients who declined anticoagulation/were unable to come for follow‐up, and six with CP‐C received VKA. Overall recanalization rate (RR) on dabigatran was 56 (47.1%); 25 (21%) complete recanalization, 31 (26%) partial recanalization and 63 (52.9%) stable PVT over median follow‐up of 32 months. Patients not anticoagulated had a spontaneous RR in 21.4% (28 patients; p = 0.005 compared with dabigatran group) and none recanalized on VKA. On multivariable analysis, predictors of recanalization on dabigatran were Factor VIII Antigen level (FVIII:Ag, HR 0.6; 95% CI 0.3–0.9, p = 0.032), non‐occlusive PVT (HR 3.5, 95% CI 1.9–5.6, p = 0.025) and acute PVT (HR 2.1; 95% CI 1.5–3.2, p = 0.003). Mortality was 14 (11.8%).ConclusionOn dabigatran, 47% of 119 patients achieved portal vein recanalization over 32 months of follow‐up which was higher than the spontaneous RR (21.4%) in an untreated cohort. High Factor VIII:Ag was a predictor of non‐recanalization. Dabigatran was safe in cirrhosis (CP‐A and B) while further work is needed in CP‐C.
Lubiprostone Reduces Fat Content on MRI‐PDFF in Patients With MASLD: A 48‐Week Randomised Controlled Trial
Authors: El‐Kassas Mohamed , Mostafa Hala , Abdellatif Wessam , Shoman Sohier , Esmat Gamal , Brahmania Mayur , Liu Hongqun , Lee Samuel S. 
Published: January 2025

ABSTRACTBackground and AimsThe laxative lubiprostone has been shown to decrease intestinal permeability. We aimed to assess the safety and efficacy of lubiprostone administered for 48 weeks in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD).Approach and ResultsA randomised placebo‐controlled trial was conducted in a specialised MASLD outpatient clinic at the National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt. The recruited patients had radiological evidence of MASLD along with other criteria for diagnosis. Eligible patients were randomly assigned to receive either placebo or lubiprostone 24 μg orally twice daily for 48 weeks. The liver fat content was quantified by magnetic resonance imaging estimated proton density fat fraction (MRI‐PDFF). Between November 2020 and February 2023, 176 patients were screened, of whom 116 were eligible. Fifty‐nine patients were randomised to receive placebo, while 57 patients were randomised to receive lubiprostone. Due mostly to patient dropout (i.e., loss to follow‐up), complete data were available for 40 patients in each group. Compared with placebo group, 48‐week lubiprostone treatment significantly reduced fat quantity (p = 0.04). Despite a significant reduction in body weight in the control group, no significant difference was found between both groups regarding fibrosis score by transient elastography or in serum ALT levels. One patient in the lubiprostone group developed severe diarrhoea requiring treatment stoppage. No other serious adverse events occurred.ConclusionLubiprostone was well tolerated and reduced liver fat content as measured by MRI‐PDFF in patients with MASLD over 48 weeks. Lubiprostone appears promising to treat MASLD and warrants more extensive studies to confirm such efficacy.Trial RegistrationClinicalTrials.gov identifier: NCT05768334
Platelets and monocytes: A dynamic duo aiding in the prediction of the clinical response to thrombopoietin receptor agonists in immune thrombocytopenia?
Authors: Kapur Rick 
Published: January 2025

Patients with immune thrombocytopenia (ITP) suffer from an autoimmune bleeding disorder with an isolated low number of platelets. Platelets and megakaryocytes are targeted by the immune system, due to a loss of immune tolerance, via the action of platelet‐autoantibodies and/or cytotoxic T cells. ITP is a highly variable disorder regarding the underlying biological mechanisms, disease trajectories and treatment responses. Predictive indicators are therefore strongly warranted. To analyze the predictive response to the thrombopoietin receptor agonist eltrombopag, in this issue of the British Journal of Haematology, Osuna‐Gomez and co‐workers research platelet‐leukocyte complexes in 38 ITP patients upon treatment with eltrombopag. Elevated platelet counts upon treatment with eltrombopag were associated with increased complexes of platelets bound to leucocytes. A higher percentage of monocytes bound to platelets, with an increased IL‐10 production in monocytes, was found to be associated to a favorable clinical response to treatment with eltrombopag. Further validation is required but these findings reveal the potential of analyzing platelet‐monocyte complexes as a predictive indicator for the clinical response to eltrombopag in patients with ITP.Commentary on: Osuna‐Gómez et al. Interplay of leucocyte‐platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients. Br J Haematol 2025 (Online ahead of print). doi: 10.1111/bjh.19779.
IDOL alleviates the body weight by upregulating UCP‐1 in mice
Authors: Guan Hua , Wang Le , Tang Chengcheng , Xu Hao , Xiang Aoqi , Chen Xiaochang , Yu Qi , Xu Lixian 
Published: January 2025

AbstractBackgroundGiven the potential role of brown adipose tissue (BAT) in stimulating energy expenditure, activating BAT can be an effective anti‐obesity treatment. Here, we aimed to use adenoviruses to establish the effect of the inducible degrader of the low density lipoprotein receptor (IDOL) in the formation of BAT.MethodsIDOL or green fluorescent protein was overexpressed by adenovirus and injected into the scapula of C57BL/6J mice and fed with high‐fat diet for 12 weeks. We measured the body weight, morphology of lipid droplets, lipid profiles and adipogenesis protein expression levels. BAT was isolated, and RNA sequencing was performed to identify the differentially expressed genes and related signaling pathways. Finally, we conducted western blot to verify the authenticity and reliability of the RNA sequencing results.ResultsCompared with the control group, IDOL overexpression led to a significant reduction in body weight, consistent with the weight of adipose tissues and organs. Further studies show IDOL promotion increased ATGL, perilipin 1 and UCP‐1 expression in BAT. However, perilipin 1 protein expression was significantly reduced in the Ad‐IDOL group in epididymal white adipose tissue, while there was no significant difference in adiponectin, ATGL and perilipin 1 protein expression in inguinal white adipose tissue. Notably, serum FGF21 and leptin protein expression were negatively related to the adipose tissue decrease after Ad‐IDOL administration. RNA sequencing analysis identified 1256 differentially expressed genes that were prominently enriched across nine signalling pathways. Additionally, the protein expression of PGAM2, G6PC1 and phosphorylation‐AMPK was significantly increased after overexpression IDOL in BAT, which was consistent with the results of the RNA sequencing analysis.ConclusionsOur research demonstrated that IDOL overexpression alleviates the body weight by promoting the phosphorylation of AMPK to upregulate the UCP‐1 and ATGL exacerbating lipolysis in BAT.