bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multifunctional 3D Supermolecular Co Coordination Polymer With Potential for CO2 Adsorption, Antibacterial Activity, and Selective Sensing of Fe3+/Cr3+ Ions and TNP
Authors: Zhou Xiaojing , Liu Lili , Kou Hang , Zheng Shimei , Song Mingjun , Lu Jitao , Tai Xishi 
Published: July 2021

A 3D supermolecular structure [Co3(L)2 (2,2′-bipy)2](DMF)3(H2O)3 1) (H3L = 4,4′,4″-nitrilotribenzoic acid) has been constructed based on H3L, and 2,2′-bipy ligands under solvothermal conditions. Compound 1 can be described as a (3, 6)-connected kgd topology with a Schläfli symbol (43)2(46.66.83) formed by [Co3(CO2)6] secondary building units. The adsorption properties of the activated sample 1a has been studied; the result shows that 1a has a high adsorption ability: the CO2 uptakes were 74 cm3·g−1 at 273 K, 50 cm3·g−1 at 298 K, the isosteric heat of adsorption (Qst) is 25.5 kJ mol−1 at zero loading, and the N2 adsorption at 77 K, 1 bar is 307 cm3 g−1. Magnetic measurements showed the existence of an antiferromagnetic exchange interaction in compound 1, besides compound 1 exhibits effective luminescent performance for Fe3+/Cr3+ and TNP.
Clinical Significance of Ventricular Tachyarrhythmias in Patients Undergoing Valve Replacement: A Nationwide Population-Based Study
Authors: Li Guan-Yi , Chen Yun-Yu , Chien Kuo-Liong , Lin Yenn-Jiang , Kuo Tzu-Ting , Chung Fa-Po 
Published: July 2021

Background: The clinical significance and outcomes of ventricular tachyarrhythmias (VTa) in patients undergoing valve replacement have rarely been reported.Objective: This study aimed to investigate the incidence and outcome of VTa after surgical valve replacement.Methods: We conducted a population-based retrospective cohort study using data obtained from the Taiwan National Health Insurance Research Database. In total, 10,212 patients were selected after 1:1 propensity-score matching based on the type of prosthetic valve used (mechanical vs. bioprosthetic). Various outcomes during long-term follow-up were analyzed.Results: After a median follow-up period of 59.6 months, the crude incidence rate of VTa after surgical valve replacement was 4.8/1,000 person-years, and the cumulative incidence of VTa persistently increased after surgery. Furthermore, the occurrences of VTa after valve replacement significantly increased the risk of cardiovascular (CV) death (P &lt; 0.001, HR 1.67, 95% CI 1.41–1.96), stroke- (P &lt; 0.001, HR 1.66, 95% CI 1.37–2.01), atrial fibrillation- (P &lt; 0.001, HR 2.80, 95% CI 2.42–3.24), and congestive heart failure-related hospitalization (P &lt; 0.001, HR 2.61, 95% CI 2.30–2.95). Among patients with VTa, all-cause mortality (P = 0.001, HR 0.49, 95% CI 0.32–0.75) and CV death (P = 0.047, HR 0.58, 95% CI 0.34–0.99) in those with implantable cardioverter-defibrillator (ICD) implantation were lower than those without.Conclusion: The crude incidence rate of VTa after surgical valve replacement was 4.8/1,000 person-years, and the cumulative incidence of VTa persistently increased during follow-up. The presence of VTa after surgical valve replacement increases hospitalization and CV death, while ICD implantation reduced the mortality rate in these patients.
Cognitive Impairments in Schizophrenia: A Study in a Large Clinical Sample Using Natural Language Processing
Authors: Mascio Aurelie , Stewart Robert , Botelle Riley , Williams Marcus , Mirza Luwaiza , Patel Rashmi , Pollak Thomas , Dobson Richard , Roberts Angus 
Published: July 2021

Background: Cognitive impairments are a neglected aspect of schizophrenia despite being a major factor of poor functional outcome. They are usually measured using various rating scales, however, these necessitate trained practitioners and are rarely routinely applied in clinical settings. Recent advances in natural language processing techniques allow us to extract such information from unstructured portions of text at a large scale and in a cost effective manner. We aimed to identify cognitive problems in the clinical records of a large sample of patients with schizophrenia, and assess their association with clinical outcomes.Methods: We developed a natural language processing based application identifying cognitive dysfunctions from the free text of medical records, and assessed its performance against a rating scale widely used in the United Kingdom, the cognitive component of the Health of the Nation Outcome Scales (HoNOS). Furthermore, we analyzed cognitive trajectories over the course of patient treatment, and evaluated their relationship with various socio-demographic factors and clinical outcomes.Results: We found a high prevalence of cognitive impairments in patients with schizophrenia, and a strong correlation with several socio-demographic factors (gender, education, ethnicity, marital status, and employment) as well as adverse clinical outcomes. Results obtained from the free text were broadly in line with those obtained using the HoNOS subscale, and shed light on additional associations, notably related to attention and social impairments for patients with higher education.Conclusions: Our findings demonstrate that cognitive problems are common in patients with schizophrenia, can be reliably extracted from clinical records using natural language processing, and are associated with adverse clinical outcomes. Harvesting the free text from medical records provides a larger coverage in contrast to neurocognitive batteries or rating scales, and access to additional socio-demographic and clinical variables. Text mining tools can therefore facilitate large scale patient screening and early symptoms detection, and ultimately help inform clinical decisions.
Insights from Fumarole Gas Geochemistry on the Recent Volcanic Unrest of Pico do Fogo, Cape Verde
Authors: Melián Gladys V. , Hernández Pedro A. , Pérez Nemesio M. , Asensio-Ramos María , Padrón Eleazar , Alonso Mar , Padilla Germán D. , Barrancos José , Sortino Francesco , Sumino Hirochicka , Rodríguez Fátima , Amonte Cecilia , Silva Sonia , Cardoso Nadir , Pereira José M. 
Published: July 2021

We report the results of the geochemical monitoring of the fumarolic discharges at the Pico do Fogo volcano in Cape Verde from 2007 to 2016. During this period Pico do Fogo experienced a volcanic eruption (November 23, 2014) that lasted 77 days, from a new vent ∼2.5 km from the fumaroles. Two fumaroles were sampled, a low (F1∼100°C) and a medium (F2∼300°C) temperature. The variations observed in the δ18O and δ2H in F1 and F2 suggest different fluid source contributions and/or fractionation processes. Although no significant changes were observed in the outlet fumarole temperatures, two clear increases were observed in the vapor fraction of fumarolic discharges during the periods November 2008–2010 and 2013–2014. Also, two sharp peaks were observed in CO2/CH4ratios at both fumaroles, in November 2008 and November 2013. This confirms that gases with a strong magmatic component rose towards the surface within the Pico do Fogo system during 2008 and 2013. Further, F2 showed two CO2/Stotalpeaks, the first in late 2010 and the second after eruption onset, suggesting the occurrence of magmatic pulses into the volcanic system. Time series of He/CO2, H2/CO2and CO/CO2ratios are low in 2008–2009, and high in 2013–2014 period, supporting the hypothesis of fluid input from a deeper magmatic source. Regarding to the isotopic composition, increases in air-corrected3He/4He ratios are observed in both fumaroles; F1 showed a peak in 2010 from a minimum in 2009 during the first magmatic reactivation onset and another in late 2013, while F2 displayed a slower rise to its maximum in late 2013. The suite of geochemical species analyzed have considerably different reactivities, hence these integrated geochemical time-series can be used to detect the timing of magmatic arrivals to the base of the system, and importantly, indicate the typical time lags between gas release periods at depth and their arrival at the surface. The high3He/4He ratios in both fumaroles in the range observed for mid-ocean ridge basalts, indicating that He is predominantly of upper mantle origin. This work supports that monitoring of the chemical and isotopic composition of the fumaroles of the Pico do Fogo volcano is a very important tool to understand the processes that take place in the magmatic-hydrothermal system and to be able to predict future episodes of volcanic unrest and to mitigate volcanic risk.
Association of Protective HLA-A With HLA-B∗27 Positive Ankylosing Spondylitis
Authors: Nordin Jessika , Pettersson Mats , Rosenberg Lina Hultin , Mathioudaki Argyri , Karlsson Åsa , Murén Eva , Tandre Karolina , Rönnblom Lars , Kastbom Alf , Cedergren Jan , Eriksson Per , Söderkvist Peter , Lindblad-Toh Kerstin , Meadows Jennifer R. S. 
Published: July 2021

ObjectivesTo further elucidate the role of the MHC in ankylosing spondylitis by typing 17 genes, searching for HLA-B∗27 independent associations and assessing the impact of sex on this male biased disease.MethodsHigh-confidence two-field resolution genotyping was performed on 310 cases and 2196 controls using an n-1 concordance method. Protein-coding variants were called from next-generation sequencing reads using up to four software programs and the consensus result recorded. Logistic regression tests were applied to the dataset as a whole, and also in stratified sets based on sex or HLA-B∗27 status. The amino acids driving association were also examined.ResultsTwenty-five HLA protein-coding variants were significantly associated to disease in the population. Three novel protective associations were found in a HLA-B∗27 positive population, HLA-A∗24:02 (OR = 0.4, CI = 0.2–0.7), and HLA-A amino acids Leu95 and Gln156. We identified a key set of seven loci that were common to both sexes, and robust to change in sample size. Stratifying by sex uncovered three novel risk variants restricted to the female population (HLA-DQA1∗04.01, -DQB1∗04:02, -DRB1∗08:01; OR = 2.4–3.1). We also uncovered a set of neutral variants in the female population, which in turn conferred strong effects in the male set, highlighting how population composition can lead to the masking of true associations.ConclusionPopulation stratification allowed for a nuanced investigation into the tightly linked MHC region, revealing novel HLA-B∗27 signals as well as replicating previous HLA-B∗27 dependent results. This dissection of signals may help to elucidate sex biased disease predisposition and clinical progression.
Barriers to Contraceptive Use Among Urban Adolescents and Youth in Conakry, in 2019, Guinea
Authors: Dioubaté Nafissatou , Manet Hawa , Bangoura Charlotte , Sidibé Sidikiba , Kouyaté Mariama , Kolie Delphin , Ayadi Alison M. El , Delamou Alexandre 
Published: July 2021

Background: Despite efforts to improve access to family planning, contraceptive prevalence remains relatively low among adolescents and youth in Guinea. The objective of this study was to understand the barriers to the use of modern contraceptive methods among urban adolescents and youth (15–24 years) in Conakry, Guinea.Methods: This was a qualitative study using an exploratory design. It was conducted in the capital city of Guinea, Conakry in 2019. Respondents included adolescents and youth aged 15–24 years, health care providers, and parents of adolescents and youth. In-depth individual interviews (IDIs) and focus group discussions (FGDs) were used to collect the data. Sixty IDIs and ten FGDs were planned in Conakry. These data were recorded and transcribed, when applicable, from the local languages into French in an anonymous manner. The data were analyzed using a mixed (inductive and deductive) thematic approach following the elements of the socio-ecological model.Results: Overall, 56 IDIs and 10 FGDs were conducted with 136 participants and included in this analysis. Respondents were adolescents (16%), youth (30%), and key informants (54%) who were health care providers (public and private), decision-makers, parents of adolescents and youth, and neighbors. Among adolescent respondents, 75% were female, and of the youth, 61% were female. Our analysis indicates various and interrelated barriers that limit the access and use of contraceptives by adolescents and youth. These included the individual (fear of side effects, cost, and rumor-related misinformation), interpersonal or family (spouse perception and sexuality taboo and perception of sexual activity before marriage), sociocultural (religious prohibitions and ethnicity), and health care system (breakdown of contraceptive methods in public health facilities, perception of service delivery, provider attitudes, visiting hours, geographic proximity of services, and quality of training received by health care providers) barriers.Conclusion: In our context, the use of modern contraceptive methods by adolescents and youth is influenced by an interaction of various barriers, including individual, interpersonal, sociocultural, and health care system factors. Strengthening contraceptive uptake interventions by involving different stakeholders, including adolescents, parents, religious, and community leaders, and improving the quality of sexual and reproductive health services would help in reducing barriers to contraceptive use among adolescents and youth.
Risk of HBV Reactivation in Patients With Resolved HBV Infection Receiving Anti-CD19 Chimeric Antigen Receptor T Cell Therapy Without Antiviral Prophylaxis
Authors: Li Ping , Zhou Lili , Ye Shiguang , Zhang Wenjun , Wang Junbang , Tang Xiaochen , Liu Jie , Xu Yangyang , Qian Wenbin , Liang Aibin 
Published: July 2021

BackgroundChimeric antigen receptor (CAR) T-cell therapy has emerged as a novel treatment modality for hematologic malignancies and is predicted to experience widespread use in the near future. However, not all risks associated with this novel approach are well defined. There are few data in the risk of HBV reactivation and limited experience in management in patients with resolved HBV infection who undergo CAR-T cell therapy.MethodsWe performed a post-hoc analysis of a prospective clinical trial of anti-CD19 CAR-T (CART19) cell therapy in patients with relapsed or refractory (r/r) B-cell malignancies, and aimed at exploring the actual risk of HBV reactivation in a cohort of patients with resolved HBV infection receiving CART19 cell therapy in the absence of antiviral prophylaxis.ResultsIn this study, we investigated the risk of HBV reactivation after CART19 cell therapy in 30 consecutive patients with B-cell malignancies and resolved HBV infection without antiviral prophylaxis, in the Tongji Hospital of Tongji University. In this cohort, two patients developed HBV reactivation 2 months and 14 months after CAR-T cell infusion, respectively, the latter of whom developed severe hepatitis. These findings showed that the incidence of HBV reactivation was 6.67% (95% CI, 0.8–22.1). Specifically, none of the 21 patients who were HBsAb positive (0.0%) versus two of nine patients who were HBsAb negative (22.2%) experienced HBV reactivation (p = 0.03), suggesting HbsAb seronegativity at baseline is a possible risk factor in this population. Although use of tocilizumab or corticosteroids has been associated with increased risk of HBV reactivation, none of the patients who received these agents had HBV reactivation in this study.ConclusionThis is the first and largest study to assess the true incidence of HBV reactivation in patients with resolved HBV infection receiving CART19 cell therapy without antiviral prophylaxis. This study highlights that this population are at risk of developing HBV reactivation and indicates that close monitoring of HBV DNA is required in the absence of antiviral prophylaxis. In addition, antiviral prophylaxis is recommended in the HBsAb-negative subpopulation.
Chronic Obstructive Pulmonary Disease Patients Have Increased Levels of Plasma Inflammatory Mediators Reported Upregulated in Severe COVID-19
Authors: Acevedo Nathalie , Escamilla-Gil Jose Miguel , Espinoza Héctor , Regino Ronald , Ramírez Jonathan , Florez de Arco Lucila , Dennis Rodolfo , Torres-Duque Carlos A. , Caraballo Luis 
Published: July 2021

BackgroundChronic obstructive pulmonary disease (COPD) is associated with increased risk of severe COVID-19, but the mechanisms are unclear. Besides, patients with severe COVID-19 have been reported to have increased levels of several immune mediators.MethodsNinety-two proteins were quantified in 315 plasma samples from 118 asthmatics, 99 COPD patients and 98 healthy controls (age 40-90 years), who were recruited in Colombia before the COVID-19 pandemic. Protein levels were compared between each disease group and healthy controls. Significant proteins were compared to the gene signatures of SARS-CoV-2 infection reported in the “COVID-19 Drug and Gene Set Library” and with experimentally tested protein biomarkers of severe COVID-19.ResultsForty-one plasma proteins showed differences between patients and controls. Asthmatic patients have increased levels in IL-6 while COPD patients have a broader systemic inflammatory dysregulation driven by HGF, OPG, and several chemokines (CXCL9, CXCL10, CXCL11, CX3CL1, CXCL1, MCP-3, MCP-4, CCL3, CCL4 and CCL11). These proteins are involved in chemokine signaling pathways related with response to viral infections and some, were found up-regulated upon SARS-CoV-2 experimental infection of Calu-3 cells as reported in the COVID-19 Related Gene Sets database. An increase of HPG, CXCL9, CXCL10, IL-6, MCP-3, TNF and EN-RAGE has also been experimentally detected in patients with severe COVID-19.ConclusionsCOPD patients have altered levels of plasma proteins that have been reported increased in patients with severe COVID-19. Our study suggests that COPD patients have a systemic dysregulation in chemokine networks (including HGF and CXCL9) that could make them more susceptible to severe COVID-19. Also, that IL-6 levels are increased in some asthmatic patients (especially in females) and this may influence their response to COVID-19. The findings in this study depict a novel panel of inflammatory plasma proteins in COPD patients that may potentially associate with increased susceptibility to severe COVID-19 and might be useful as a biomarker signature after future experimental validation.
Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection
Authors: Marim Fernanda Martins , Teixeira Danielle Cunha , Queiroz-Junior Celso Martins , Valiate Bruno Vinicius Santos , Alves-Filho Jose Carlos , Cunha Thiago Mattar , Dantzer Robert , Teixeira Mauro Martins , Teixeira Antonio Lucio , Costa Vivian Vasconcelos 
Published: July 2021

Zika virus (ZIKV) is an arbovirus belonging to Flaviviridae family that emerged as a global health threat due to its association with microcephaly and other severe neurological complications, including Guillain-Barré Syndrome (GBS) and Congenital Zika Syndrome (CZS). ZIKV disease has been linked to neuroinflammation and neuronal cell death. Neurodegenerative processes may be exacerbated by metabolites produced by the kynurenine pathway, an important pathway for the degradation of tryptophan, which induces neuronal dysfunction due to enhanced excitotoxicity. Here, we exploited the hypothesis that ZIKV-induced neurodegeneration can be rescued by blocking a target enzyme of the kynurenine pathway, the Indoleamine 2,3-dioxygenase (IDO-1). RT-PCR analysis showed increased levels of IDO-1 RNA expression in undifferentiated primary neurons isolated from wild type (WT) mice infected by ZIKV ex vivo, as well as in the brain of ZIKV-infected A129 mice. Pharmacological inhibition of IDO-1 enzyme with 1-methyl-D-tryptophan (1-MT), in both in vitro and in vivo systems, led to significant reduction of ZIKV-induced neuronal death without interfering with the ability of ZIKV to replicate in those cells. Furthermore, in vivo analyses using both genetically modified mice (IDO-/- mice) and A129 mice treated with 1-MT resulted in reduced microgliosis, astrogliosis and Caspase-3 positive cells in the brain of ZIKV-infected A129 mice. Interestingly, increased levels of CCL5 and CXCL-1 chemokines were found in the brain of 1-MT treated-mice. Together, our data indicate that IDO-1 blockade provides a neuroprotective effect against ZIKV-induced neurodegeneration, and this is amenable to inhibition by pharmacological treatment.
Mapping Autoantibodies in Children With Acute Rheumatic Fever
Authors: McGregor Reuben , Tay Mei Lin , Carlton Lauren H. , Hanson-Manful Paulina , Raynes Jeremy M. , Forsyth Wasan O. , Brewster Diane T. , Middleditch Martin J. , Bennett Julie , Martin William John , Wilson Nigel , Atatoa Carr Polly , Baker Michael G. , Moreland Nicole J. 
Published: July 2021

BackgroundAcute rheumatic fever (ARF) is a serious sequela of Group A Streptococcus (GAS) infection associated with significant global mortality. Pathogenesis remains poorly understood, with the current prevailing hypothesis based on molecular mimicry and the notion that antibodies generated in response to GAS infection cross-react with cardiac proteins such as myosin. Contemporary investigations of the broader autoantibody response in ARF are needed to both inform pathogenesis models and identify new biomarkers for the disease.MethodsThis study has utilised a multi-platform approach to profile circulating autoantibodies in ARF. Sera from patients with ARF, matched healthy controls and patients with uncomplicated GAS pharyngitis were initially analysed for autoreactivity using high content protein arrays (Protoarray, 9000 autoantigens), and further explored using a second protein array platform (HuProt Array, 16,000 autoantigens) and 2-D gel electrophoresis of heart tissue combined with mass spectrometry. Selected autoantigens were orthogonally validated using conventional immunoassays with sera from an ARF case-control study (n=79 cases and n=89 matched healthy controls) and a related study of GAS pharyngitis (n=39) conducted in New Zealand.ResultsGlobal analysis of the protein array data showed an increase in total autoantigen reactivity in ARF patients compared with controls, as well as marked heterogeneity in the autoantibody profiles between ARF patients. Autoantigens previously implicated in ARF pathogenesis, such as myosin and collagens were detected, as were novel candidates. Disease pathway analysis revealed several autoantigens within pathways linked to arthritic and myocardial disease. Orthogonal validation of three novel autoantigens (PTPN2, DMD and ANXA6) showed significant elevation of serum antibodies in ARF (p &lt; 0.05), and further highlighted heterogeneity with patients reactive to different combinations of the three antigens.ConclusionsThe broad yet heterogenous elevation of autoantibodies observed suggests epitope spreading, and an expansion of the autoantibody repertoire, likely plays a key role in ARF pathogenesis and disease progression. Multiple autoantigens may be needed as diagnostic biomarkers to capture this heterogeneity.