bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomy of a Violent Protest Wave: Understanding the Mechanisms of Escalation and De-Escalation in Far-Right and Anti-Fascist Street Clashes
Authors: Serbulo Leanne C. 
Published: January 2021

Abstract
With the rise of right-wing populist ideologies and ensuing social polarization, political violence has become more widespread. Between 2017 and 2019, far-right extremists and anti-fascists engaged in more than twenty violent protest clashes in Portland, Oregon, USA. Through a protest event analysis of those clashes supplemented with a case study of the protest wave, this paper explores how the mechanisms of radicalization and de-radicalization operate when two violent protest movements collide and interact with state security forces. The three-way interaction among a movement, counter-movement, and the police can produce unanticipated outcomes. For example, rather than de-escalating the situation, police underbidding resulted in an increase in violence between the two movements. Understanding how the mechanisms of radicalization and de-radicalization function in a movement/counter-movement protest cycle can provide insight into the ways in which a movement’s strategy and their adversaries’ responses to it can increase or decrease levels of violence.
Disobeying in Time of Disaster: Radicalism in the French Climate Mobilizations
Authors: Gaborit Maxime 
Published: January 2021

Abstract
Since 2018, climate mobilizations have been shaping political life in Europe. Young people are at the heart of this mobilization, both because of their massive nationwide presence in intergenerational demonstrations, but also because of their own modes of action, such as the climate strikes that have been emerging since January 2019. Within these mobilizations, forms of radicalism are expressed through an important support for civil disobedience, such as blocking actions, as well as support – for a significant part of protestors – for material damage. This paper analyzes the new forms of youth radicalism in their link to the social determinations of the awareness of the climate catastrophe. Based on a demonstration survey concerning three French cities for the strike of March 15, 2019, and in Paris for the strike of September 20th, which collected more than 1,800 questionnaires, this paper sets out to show the sociological profiles of radical individuals, which distinguish themselves by significant cultural capital and left-wing familial political socialization. The exploitation of the data collected shows that these new forms of radicalism are conditioned by an awareness of the climate emergency, deeply linked to family legacies and specific academic curricula. The radicalization of inherited dispositions leads these individuals to go beyond the legality/illegality framework, and to favor a debate on the effectiveness of the means of action, in which the link with conventional democratic participation is constantly questioned.
“We Are Radical In Our Kindness”: The Political Socialisation, Motivations, Demands and Protest Actions of Young Environmental Activists in Britain
Authors: Pickard Sarah , Bowman Benjamin , Arya Dena 
Published: January 2021

Abstract
The year 2018 was a watershed in environmental activism, especially regarding young activists. Greta Thunberg started her School Strikes for Climate and the environmental movement Extinction Rebellion was founded. This article deals with young people’s involvement in these two global movements. It draws on 60 semi-structured interviews carried out with young environmental activists before, during and after protest actions under the auspices of the climate strikes and/or Extinction Rebellion in five British locations.
The period of the political socialisation of this young generation is outlined and how it contributes to young people becoming environmental activists. The article then identifies the “radical” demands made by young environmental activists and their “radical” repertoire of contention in relation to their perceptions of the “radical” compared to hegemonic definitions.
The interviews show that these young environmentalists are part of a generation of activists committed to obtaining significant change from powerholders through the use of deliberately non-violent direct action that challenges academic perceptions of radical repertoires of contention.
Association between cervical disc disease and lesions of multiple sclerosis
Authors: Alkrenawi Marwan , Osherov Michael , Simonovich Azaria , Droujin Jonathan , Milo Ron , Appel Shmuel 
Published: January 2021

Background Cervical discopathy and demyelinating lesions often co-exist in patients with multiple sclerosis (MS). Our study examines the possible association between these two pathologies. Methods Medical records and cervical magnetic resonance imaging scans of MS patients with cervical discopathy who were seen at our MS clinic during 2018 were retrospectively reviewed. The severity of the disc disease was classified as grade I (no compression), grade II (compression of the dural sac) and grade III (cord compression). The spinal cord in each scan was divided into six segments corresponding to the intervertebral space of the spine (C1–C6). Each segment was defined as containing demyelinating lesion and disc pathology (group 1), demyelinating lesion without disc pathology (group 2), disc pathology without demyelinating lesion (group 3) and no demyelinating lesion or disc pathology (group 4). Fisher’s exact test was used to test the association between demyelinating lesions and disc pathology. Results Thirty-four MS patients with cervical discopathy were included in the study (26 females; average age 42.9 ± 13.7 years; average disease duration 8.4 ± 5.4 years). A total of 204 spinal cord segments were evaluated. Twenty-four segments were classified as group 1, 27 segments as group 2, 52 segments as group 3 and 101 segments as group 4. There was no association between demyelinating lesions and the grade of disc disease ( p = 0.1 for grade I, p = 0.3 for grade II and p = 1 for grade III disc disease). Conclusion Our study did not find any association between cervical disc disease and demyelinating spinal cord lesion.
Healthcare in transition in the Republic of Armenia: the evolution of emergency medical systems and directions forward
Authors: Chekijian Sharon , Truzyan Nune , Stepanyan Taguhi , Bazarchyan Alexander 
Published: January 2021

AbstractArmenia, an ex-Soviet Republic in transition since independence in 1991, has made remarkable strides in development. The crisis of prioritization that has plagued many post-Soviet republics in transition has meant differential growth in varied sectors in Armenia. Emergency systems is one of the sectors which is neglected in the current drive to modernize. The legacy of the Soviet Semashko system has left a void in specialized care including emergency care. This manuscript is a descriptive overview of the current state of emergency care in Armenia using in-depth key informant interviews and review of published and unpublished internal United States Agency for International Development (USAID) and Ministry of Health (MOH) documents as well as data from the Yerevan Municipal Ambulance Service and international agencies. The Republic of Artsakh is briefly discussed.The development of emergency care systems is an extremely efficient way to provide care across many different conditions in many age groups. Conditions such as traumatic injuries, heart attacks, cardiac arrest, stroke, and respiratory failure are very time-dependent. Armenia has a decent emergency infrastructure in place and has the benefit of an educated and skilled physician workforce. The missing piece of the puzzle appears to be investment in graduate and post-graduate education in emergency care and development of hospital-based emergency care for stabilization of stroke, myocardial infarction, trauma, and sepsis as well as other acute conditions.
Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach
Authors: Fang Mike , Richardson Brian , Cameron Cheryl M. , Dazard Jean-Eudes , Cameron Mark J. 
Published: January 2021

AbstractBackgroundIn this study, we demonstrate that our modified Gene Set Enrichment Analysis (GSEA) method, drug perturbation GSEA (dpGSEA), can detect phenotypically relevant drug targets through a unique transcriptomic enrichment that emphasizes biological directionality of drug-derived gene sets.ResultsWe detail our dpGSEA method and show its effectiveness in detecting specific perturbation of drugs in independent public datasets by confirming fluvastatin, paclitaxel, and rosiglitazone perturbation in gastroenteropancreatic neuroendocrine tumor cells. In drug discovery experiments, we found that dpGSEA was able to detect phenotypically relevant drug targets in previously published differentially expressed genes of CD4+T regulatory cells from immune responders and non-responders to antiviral therapy in HIV-infected individuals, such as those involved with virion replication, cell cycle dysfunction, and mitochondrial dysfunction. dpGSEA is publicly available athttps://github.com/sxf296/drug_targeting.ConclusionsdpGSEA is an approach that uniquely enriches on drug-defined gene sets while considering directionality of gene modulation. We recommend dpGSEA as an exploratory tool to screen for possible drug targeting molecules.
Postoperative outcomes in surgical COVID-19 patients: a multicenter cohort study
Authors: Carrier François Martin , Amzallag Éva , Lecluyse Vincent , Côté Geneviève , Couture Étienne J. , D’Aragon Frédérick , Kandelman Stanislas , Turgeon Alexis F. , Deschamps Alain , Nitulescu Roy , Djade Codjo Djignefa , Girard Martin , Beaulieu Pierre , Richebé Philippe 
Published: January 2021

AbstractBackgroundData on postoperative outcomes of the COVID-19 patient population is limited. We described COVID-19 patients who underwent a surgery and the pandemic impact on surgical activities.MethodsWe conducted a multicenter cohort study between March 13 and June 192,020. We included all COVID-19 patients who underwent surgery in nine centres of the Province of Québec, the Canadian province most afflicted by the pandemic. We also included concomitant suspected COVID-19 (subsequently confirmed not to have COVID-19) patients and patients who had recovered from it. We collected data on baseline characteristics, postoperative complications and postoperative mortality. Our primary outcome was 30-day mortality. We also collected data on overall surgical activities during this first wave and during the same period in 2019.ResultsWe included 44 COVID-19 patients, 18 suspected patients, and 18 patients who had recovered from COVID-19 at time of surgery. Among the 44 COVID-19 patients, 31 surgeries (71%) were urgent and 16 (36%) were major. In these patients, pulmonary complications were frequent (25%) and 30-day mortality was high (15.9%). This mortality was higher in patients with symptoms (23.1%) compared to those without symptoms (5.6%), although not statistically significant (p = 0.118). Of the total 22,616 cases performed among participating centres during the study period, only 0.19% had COVID-19 at the time of surgery. Fewer procedures were performed during the study period compared to the same period in 2019 (44,486 cases).ConclusionIn this Canadian cohort study, postoperative 30-day mortality in COVID-19 patients undergoing surgery was high (15.9%). Although few surgeries were performed on COVID-19 patients, the pandemic impact on surgical activity volume was important.Trial registrationClinicalTrials.gov Identifier:NCT04458337.
Predictors of mortality and adverse events in patients with infective endocarditis: a retrospective real world study in a surgical centre
Authors: Scheggi Valentina , Merilli Irene , Marcucci Rossella , Del Pace Stefano , Olivotto Iacopo , Zoppetti Nicola , Ceschia Nicole , Andrei Valentina , Alterini Bruno , Stefàno Pier Luigi , Marchionni Niccolò 
Published: January 2021

Abstract
Purpose
Mortality in infective endocarditis (IE) is still high, and the long term prognosis remains uncertain. This study aimed to identify predictors of long-term mortality for any cause, adverse event rate, relapse rate, valvular and ventricular dysfunction at follow-up, in a real-world surgical centre.

Methods
We retrospectively analyzed 363 consecutive episodes of IE (123 women, 34%) admitted to our department with a definite diagnosis of non-device-related IE. Median follow-up duration was 2.9 years. Primary endpoints were predictors of mortality, recurrent endocarditis, and major non-fatal adverse events (hospitalization for any cardiovascular cause, pace-maker implantation, new onset of atrial fibrillation, sternal dehiscence), and ventricular and valvular dysfunction at follow-up.

Results
Multivariate analysis independent predictors of mortality showed age (HR per unit 1.031, p < 0.003), drug abuse (HR 3.5, p < 0.002), EUROSCORE II (HR per unit 1.017, p < 0.0006) and double valve infection (HR 2.3, p < 0.001) to be independent predictors of mortality, while streptococcal infection remained associated with a better prognosis (HR 0.5, p < 0.04). Major non-fatal adverse events were associated with age (HR 1.4, p < 0.022). New episodes of infection were correlated with S aureus infection (HR 4.8, p < 0.001), right-sided endocarditis (HR 7.4, p < 0.001), spondylodiscitis (HR 6.8, p < 0.004) and intravenous drug abuse (HR 10.3, p < 0.001). After multivariate analysis, only drug abuse was an independent predictor of new episodes of endocarditis (HR 8.5, p < 0.001). Echocardiographic follow-up, available in 95 cases, showed a worsening of left ventricular systolic function (p < 0.007); severe valvular dysfunction at follow-up was reported only in 4 patients, all of them had mitral IE (p < 0.03).

Conclusions
The present study highlights some clinical, readily available factors that can be useful to stratify the prognosis of patients with IE.
Reaching everyone in general practice? Feasibility of an integrated domestic violence training and support intervention in primary care
Authors: Szilassy Eszter , Roy Jessica , Williamson Emma , Pitt Katherine , Man Mei-See , Feder Gene 
Published: January 2021

Abstract
Background
Primary care needs to respond effectively to patients experiencing or perpetrating domestic violence and abuse (DVA) and their children, but there is uncertainty about the value of integrated programmes. The aim of the study was to develop and test the feasibility of an integrated primary care system-level training and support intervention, called IRIS+ (Enhanced Identification and Referral to Improve Safety), for all patients affected by DVA. IRIS+ was an adaptation of the original IRIS (Identification and Referral to Improve Safety) model designed to reach female survivors of DVA.

Methods
Observation of training; pre/post intervention questionnaires with clinicians and patients; data extracted from medical records and DVA agency; semi-structured interviews with clinicians, service providers and referred adults and children. Data collection took place between May 2017 and April 2018. Mixed method analysis was undertaken to triangulate data from various sources to assess the feasibility and acceptability of the intervention.

Results
Clinicians and service providers believed that the IRIS+ intervention had filled a service gap and was a valuable resource in identifying and referring women, men and children affected by DVA. Despite increased levels of preparedness reported by clinicians after training in managing the complexity of DVA in their practice, the intervention proved to be insufficient to catalyse identification and specialist referral of men and direct identification and referral (without their non-abusive parents) of children and young people. The study also revealed that reports provided to general practice by other agencies are important sources of information about adult and children patients affected by DVA. However, in the absence of guidance about how to use this information in patient care, there are uncertainties and variation in practice.

Conclusions
The study demonstrates that the IRIS+ intervention is not feasible in the form and timeframe we evaluated. Further adaptation is required to achieve identification and referral of men and children in primary care: an enhanced focus on engagement with men, direct engagement with children, and improved guidance and training on responding to reports of DVA received from other agencies.
Amygdalin promotes the activity of T cells to suppress the progression of HBV-related hepatocellular carcinoma via the JAK2/STAT3 signaling pathway
Authors: Wang Ruoyu , Zhang Dong , Sun Kewei , Peng Jianping , Zhu Wenfang , Yin Sihan , Tang Dan , Wu Yunan 
Published: January 2021

Abstract
Background
Hepatitis B virus (HBV) infection is a high-risk factor of hepatocellular carcinoma (HCC). Cellular immune responses are essential for HCC development, and the CD4+ and CD8+ T subtypes are identified as the primary anti-tumor immune cells. In the study, we investigated the effect and mechanism of amygdalin in the cellular immune response in HBV-related HCC and HCC progression.

Methods
The cell proliferation was examined by MTT analysis. Cells metastasis ability was detected by Invasion and migration assays. Quantification of apoptotic cells was performed with Flow cytometer assay. The protein levels of p-STAT3, STAT3, p-JAK2, JAK2, caspase-3, cleaved caspase-3 were detected by performing immunoblotting assays.

Results
We demonstrate that amygdalin treatment could rescue the HBV-T cell viability and IFN-γ and TNF-αproduction. In HBV-T cells, the MFI levels of CD8+ are lower than that in NC-T cells. Moreover, the phosphorylation levels of STAT3 and JAK2 are higher in HBV-T cells, compared to those in NC-T cells, and then reduced by amygdalin treatment. Co-culture with HBV-T cells could reduce IFN-γ and TNF-α, production while increase IL-6 and IL-10 production in HepG2.2.15 cells; these alterations could be partially reversed by amygdalin pretreatment. Finally, co-culture with HBV-T cells significantly promoted the cell viability, inhibited the apoptosis, and promoted the migration of HepG2.2.15 cells, and these alterations could be partially reversed by amygdalin treatment.

Conclusion
Our findings provide a rationale for further studies on the functions and mechanism of amygdalin inhibiting HBV-related HCC cell proliferation, invasion, and migration via T cell-mediated tumor immunity.
Clinical characteristics and predictive value of lower CD4+T cell level in patients with moderate and severe COVID-19: a multicenter retrospective study
Authors: Wen Xue-song , Jiang Dan , Gao Lei , Zhou Jian-zhong , Xiao Jun , Cheng Xiao-cheng , He Bin , Chen Yue , Lei Peng , Tan Xiao-wei , Qin Shu , Zhang Dong-ying 
Published: January 2021

AbstractBackgroundIn December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, Hubei, China. Moreover, it has become a global pandemic. This is of great value in describing the clinical symptoms of COVID-19 patients in detail and looking for markers which are significant to predict the prognosis of COVID-19 patients.MethodsIn this multicenter, retrospective study, 476 patients with COVID-19 were enrolled from a consecutive series. After screening, a total of 395 patients were included in this study. All-cause death was the primary endpoint. All patients were followed up from admission till discharge or death.ResultsThe main symptoms observed in the study included fever on admission, cough, fatigue, and shortness of breath. The most common comorbidities were hypertension and diabetes mellitus. Patients with lower CD4+T cell level were older and more often male compared to those with higher CD4+T cell level. Reduced CD8+T cell level was an indicator of the severity of COVID-19. Both decreased CD4+T [HR:13.659; 95%CI: 3.235–57.671] and CD8+T [HR: 10.883; 95%CI: 3.277–36.145] cell levels were associated with in-hospital death in COVID-19 patients, but only the decrease of CD4+T cell level was an independent predictor of in-hospital death in COVID-19 patients.ConclusionsReductions in lymphocytes and lymphocyte subsets were common in COVID-19 patients, especially in severe cases of COVID-19. It was the CD8+T cell level, not the CD4+T cell level, that reflected the severity of the patient’s disease. Only reduced CD4+T cell level was independently associated with increased in-hospital death in COVID-19 patients.Trial registrationPrognostic Factors of Patients With COVID-19,NCT04292964. Registered 03 March 2020. Retrospectively registered.
A case of recurrent sterile abscesses following tetanus-diphtheria vaccination treated with corticosteroids
Authors: Kaya Abdurrahman , Kaya Sibel Yıldız 
Published: January 2021

Abstract
Background
Vaccinations have been widely used worldwide since their invention to prevent various diseases, but they can also have some adverse effects ranging from mild local reactions to serious side effects. These adverse effects are generally self-limited and resolve within a short time without any treatment. While a sterile abscess following vaccination is a rare condition in adults, many cases have been reported regarding children in the literature. Here, we report a case of recurrent sterile abscesses, which occurred after a Td vaccination, treated with corticosteroids.

Case presentation
A 22-year old woman was admitted to our department with a complaint of swelling at the site of the vaccination. On physical examination, this mass was about 6 × 6 cm in size and fluctuating, but there were no pain complaints and no redness present. She had received her Td vaccination 3 weeks ago and the swelling had started at the site of the injection 4 days following this immunization. Oral amoxicillin/clavulanic acid and local antibiotic cream were administered for 10 days. The laboratory values were unremarkable. Despite the administration of antibiotics, the swelling did not regress, and on the contrary, continued to increase in size. On ultrasound, two interconnected abscesses were observed in the subcutaneous area, and did not involve the muscle tissue. Later, the abscesses were completely drained, and the samples were cultured. The current antibiotics were continued. The gram staining of the samples revealed abundant leukocytes but no microorganisms. The solid and liquid cultures of the materials remained negative. Despite the administration of multiple drainages and antibiotics, the mass recurred. Finally, the patient was considered to have a sterile abscess due to Td immunization. The antimicrobials were stopped. Local and oral corticosteroids were initiated. The swelling regressed significantly, and the treatments continued for 7 days. The patient has been doing well and has had no recurrence for over a year.

Conclusions
Corticosteroids appeared to improve the patient and therefore we suggest that the efficacy and route of administration of steroids in this situation should be explored further.