bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rheotaxis-based sperm separation using a biomimicry microfluidic device
Authors: Sarbandi Iman Ramazani , Lesani Ali , Moghimi Zand Mahdi , Nosrati Reza 
Published: September 2021

AbstractSperm selection is crucial to assisted reproduction, influencing the success rate of the treatment cycle and offspring health. However, in the current clinical sperm selection practices, bypassing almost all the natural selection barriers is a major concern. Here, we present a biomimicry microfluidic method, inspired by the anatomy of the female reproductive tract, that separates motile sperm based on their rheotaxis behavior to swim against the flow into low shear rate regions. The device includes micropocket geometries that recall the oval-shaped microstructures of the female fallopian tube to create shear protected zones for sperm separation. Clinical tests with human samples indicate that the device is capable of isolating viable and highly motile sperm based on their rheotaxis responses, resulting in a separation efficiency of 100%. The device presents an automated alternative for the current sperm selection practices in assisted reproduction.
Efficient electromagnetic transducers for spin-wave devices
Authors: Connelly David A. , Csaba Gyorgy , Aquino Hadrian Renaldo O. , Bernstein Gary H. , Orlov Alexei , Porod Wolfgang , Chisum Jonathan 
Published: September 2021

AbstractThis paper presents a system-level efficiency analysis, a rapid design methodology, and a numerical demonstration of efficient sub-micron, spin-wave transducers in a microwave system. Applications such as Boolean spintronics, analog spin-wave-computing, and magnetic microwave circuits are expected to benefit from this analysis and design approach. These applications have the potential to provide a low-power, magnetic paradigm alternative to modern electronic systems, but they have been stymied by a limited understanding of the microwave, system-level design for spin-wave circuits. This paper proposes an end-to-end microwave/spin-wave system model that permits the use of classical microwave network analysis and matching theory towards analyzing and designing efficient transduction systems. This paper further compares magnetostatic-wave transducer theory to electromagnetic simulations and finds close agreement, indicating that the theory, despite simplifying assumptions, is useful for rapid yet accurate transducer design. It further suggests that the theory, when modified to include the exchange interaction, will also be useful to rapidly and accurately design transducers launching magnons at exchange wavelengths. Comparisons are made between microstrip and co-planar waveguide lines, which are expedient, narrowband, and low-efficiency transducers, and grating and meander lines that are capable of high-efficiency and wideband performance. The paper concludes that efficient microwave-to-spin-wave transducers are possible and presents a meander transducer design on YIG capable of launching $$\varvec{\lambda = 500}\,$$

λ
=
500

nm spin waves with an efficiency of − 4.45 dB and a 3 dB-bandwidth of 134 MHz.
Multi-scale guided feature extraction and classification algorithm for hyperspectral images
Authors: Huang Shiqi , Lu Ying , Wang Wenqing , Sun Ke 
Published: September 2021

AbstractTo solve the problem that the traditional hyperspectral image classification method cannot effectively distinguish the boundary of objects with a single scale feature, which leads to low classification accuracy, this paper introduces the idea of guided filtering into hyperspectral image classification, and then proposes a multi-scale guided feature extraction and classification (MGFEC) algorithm for hyperspectral images. Firstly, the principal component analysis theory is used to reduce the dimension of hyperspectral image data. Then, guided filtering algorithm is used to achieve multi-scale spatial structure extraction of hyperspectral image by setting different sizes of filtering windows, so as to retain more edge details. Finally, the extracted multi-scale features are input into the support vector machine classifier for classification. Several practical hyperspectral image datasets were used to verify the experiment, and compared with other spectral feature extraction algorithms. The experimental results show that the multi-scale features extracted by the MGFEC algorithm proposed in this paper are more accurate than those extracted by only using spectral information, which leads to the improvement of the final classification accuracy. This fully shows that the proposed method is not only effective, but also suitable for processing different hyperspectral image data.
The effect of two ribonucleases on the production of Shiga toxin and stx-bearing bacteriophages in Enterohaemorrhagic Escherichia coli
Authors: Lodato Patricia B. 
Published: September 2021

AbstractEnterohaemorrhagic Escherichia coli (EHEC) comprise a group of intestinal pathogens responsible for a range of illnesses, including kidney failure and neurological compromise. EHEC produce critical virulence factors, Shiga toxin (Stx) 1 or 2, and the synthesis of Stx2 is associated with worse disease manifestations. Infected patients only receive supportive treatment because some conventional antibiotics enable toxin production. Shiga toxin 2 genes (stx2) are carried in λ-like bacteriophages (stx2-phages) inserted into the EHEC genome as prophages. Factors that cause DNA damage induce the lytic cycle of stx2-phages, leading to Stx2 production. The phage Q protein is critical for transcription antitermination of stx2 and phage lytic genes. This study reports that deficiency of two endoribonucleases (RNases), E and G, significantly delayed cell lysis and impaired production of both Stx2 and stx2-phages, unlike deficiency of either enzyme alone. Moreover, scarcity of both enzymes reduced the concentrations of Q and stx2 transcripts and slowed cell growth.
Physicochemical, antioxidant properties of carotenoids and its optoelectronic and interaction studies with chlorophyll pigments
Authors: Srivastava Ruby 
Published: September 2021

AbstractThe physicochemical and antioxidant properties of seven carotenoids: antheraxanthin, β-carotene, neoxanthin, peridinin, violaxanthin, xanthrophyll and zeaxanthin were studied by theoretical means. Then the Optoelectronic properties and interaction of chlorophyll-carotenoid complexes are analysed by TDDFT and IGMPLOT. Global reactivity descriptors for carotenoids and chlorophyll (Chla, Chlb) are calculated via conceptual density functional theory (CDFT). The higher HOMO–LUMO (HL) gap indicated structural stability of carotenoid, chlorophyll and chlorophyll-carotenoid complexes. The chemical hardness for carotenoids and Chlorophyll is found to be lower in the solvent medium than in the gas phase. Results showed that carotenoids can be used as good reactive nucleophile due to lower µ and ω. As proton affinities (PAs) are much lower than the bond dissociation enthalpies (BDEs), it is anticipated that direct antioxidant activity in these carotenoids is mainly due to the sequential proton loss electron transfer (SPLET) mechanism with dominant solvent effects. Also lower PAs of carotenoid suggest that antioxidant activity by the SPLET mechanism should be a result of a balance between proclivities to transfer protons. Reaction rate constant with Transition-State Theory (TST) were estimated for carotenoid-Chlorophyll complexes in gas phase. Time dependent Density Functional Theory (TDDFT) showed that all the chlorophyll (Chla, Chlb)–carotenoid complexes show absorption wavelength in the visible region. The lower S1–T1adiabatic energy gap indicated ISC transition from S1to T1state.
Ecology of the digital world of Wikipedia
Authors: Ogushi Fumiko , Kertész János , Kaski Kimmo , Shimada Takashi 
Published: September 2021

AbstractWikipedia, a paradigmatic example of online knowledge space is organized in a collaborative, bottom-up way with voluntary contributions, yet it maintains a level of reliability comparable to that of traditional encyclopedias. The lack of selected professional writers and editors makes the judgement about quality and trustworthiness of the articles a real challenge. Here we show that a self-consistent metrics for the network defined by the edit records captures well the character of editors’ activity and the articles’ level of complexity. Using our metrics, one can better identify the human-labeled high-quality articles, e.g., “featured” ones, and differentiate them from the popular and controversial articles. Furthermore, the dynamics of the editor-article system is also well captured by the metrics, revealing the evolutionary pathways of articles and diverse roles of editors. We demonstrate that the collective effort of the editors indeed drives to the direction of article improvement.
Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees
Authors: de Brito Sanchez Gabriela , Expósito Muñoz Anna , Chen Li , Huang Weifone , Su Songkun , Giurfa Martin 
Published: September 2021

AbstractThe adipokinetic hormone (AKH) of insects is considered an equivalent of the mammalian hormone glucagon as it induces fast mobilization of carbohydrates and lipids from the fat body upon starvation. Yet, in foraging honey bees, which lack fat body storage for carbohydrates, it was suggested that AKH may have lost its original function. Here we manipulated the energy budget of bee foragers to determine the effect of AKH on appetitive responses. As AKH participates in a cascade leading to acceptance of unpalatable substances in starved Drosophila, we also assessed its effect on foragers presented with sucrose solution spiked with salicin. Starved and partially-fed bees were topically exposed with different doses of AKH to determine if this hormone modifies food ingestion and sucrose responsiveness. We found a significant effect of the energy budget (i.e. starved vs. partially-fed) on the decision to ingest or respond to both pure sucrose solution and sucrose solution spiked with salicin, but no effect of AKH per se. These results are consistent with a loss of function of AKH in honey bee foragers, in accordance with a social life that implies storing energy resources in the hive, in amounts that exceed individual needs.
Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells
Authors: Cruz Carmela Rieline V. , Ferrer Jose Lorenzo M. , Garcia Reynaldo L. 
Published: September 2021

AbstractLung cancer is the leading cause of cancer deaths worldwide, with smoking as its primary predisposing factor. Although carcinogens in cigarettes are known to cause oncogenic DNA alterations, analyses of patient cohorts revealed heterogeneous genetic aberrations with no clear driver mutations. The contribution of noncoding RNAs (ncRNAs) in the pathogenesis of lung cancer has since been demonstrated. Their dysregulation has been linked to cancer initiation and progression. A novel long noncoding RNA (lncRNA) called smoke and cancer-associated lncRNA 1 (SCAL1) was recently found upregulated in smoke-exposed adenocarcinomic alveolar epithelial cells. The present study characterized the phenotypic consequences of SCAL1 overexpression and knockdown using A549 cells as model system, with or without prior exposure to cigarette smoke extract (CSE). Increase in SCAL1 levels either by CSE treatment or SCAL1 overexpression led to increased cell migration, extensive cytoskeletal remodeling, and resistance to apoptosis. Further, SCAL1 levels were negatively correlated with intracellular levels of reactive oxygen species (ROS). In contrast, SCAL1 knockdown showed converse results for these assays. These results confirm the oncogenic function of SCAL1 and its role as a CSE-activated lncRNA that mediates ROS detoxification in A549 cells, thereby allowing them to develop resistance to and survive smoke-induced toxicity.
Confidence guides priority between forthcoming tasks
Authors: Aguilar-Lleyda David , de Gardelle Vincent 
Published: September 2021

AbstractHumans can estimate confidence in their decisions, and there is increasing interest on how this feeling of confidence regulates future behavior. Here, we investigate whether confidence in a perceptual task affects prioritizing future trials of that task, independently of task performance. To do so, we experimentally dissociated confidence from performance. Participants judged whether an array of differently colored circles was closer to blue or red, and we manipulated the mean and variability of the circles’ colors across the array. We first familiarized participants with a low mean low variability condition and a high mean high variability condition, which were matched in performance despite participants being more confident in the former. Then we made participants decide in which order to complete forthcoming trials for both conditions. Crucially, prioritizing one condition was associated with being more confident in that condition compared to the other. This relationship was observed both across participants, by correlating inter-individual heterogeneity in prioritization and in confidence, and within participants, by assessing how changes in confidence with accuracy, condition and response times could predict prioritization choices. Our results suggest that confidence, above and beyond performance, guides prioritization between forthcoming tasks, strengthening the evidence for its role in regulating behavior.
Eye movement as a biomarker of impaired organizational strategies during visual memory encoding in obsessive–compulsive disorder
Authors: Kim Minah , Shin Woncheol , Lee Tak Hyung , Kim Taekwan , Hwang Wu Jeong , Kwon Jun Soo 
Published: September 2021

AbstractThe symptoms of obsessive–compulsive disorder (OCD) are largely related to impaired executive functioning due to frontostriatal dysfunction. To better treat OCD, the development of biomarkers to bridge the gap between the symptomatic-cognitive phenotype and brain abnormalities is warranted. Therefore, we aimed to identify biomarkers of impaired organizational strategies during visual encoding processes in OCD patients by developing an eye tracking-based Rey–Osterrieth complex figure test (RCFT). In 104 OCD patients and 114 healthy controls (HCs), eye movements were recorded during memorization of the RCFT figure, and organizational scores were evaluated. Kullback–Leibler divergence (KLD) scores were calculated to evaluate the distance between a participant’s eye gaze distribution and a hypothetical uniform distribution within the RCFT figure. Narrower gaze distributions within the RCFT figure, which yielded higher KLD scores, indicated that the participant was more obsessed with detail and had less organizational strategy. The OCD patients showed lower organizational scores than the HCs. Although no group differences in KLD scores were noted, KLD scores were significantly associated with organization T scores in the OCD group. The current study findings suggest that eye tracking biomarkers of visual memory encoding provide a rapidly determined index of executive functioning, such as organizational strategies, in OCD patients.
Cosmology in the mimetic higher-curvature $$f(R,R_{\mu \nu }R^{\mu \nu })$$ gravity
Authors: Kaczmarek Adam Z. , Szczȩśniak Dominik 
Published: September 2021

AbstractIn the framework of the mimetic approach, we study the $$f(R,R_{\mu \nu }R^{\mu \nu })$$

f
(
R
,

R

μ
ν

R

μ
ν

)

gravity with the Lagrange multiplier constraint and the scalar potential. We introduce field equations for the discussed theory and overview their properties. By using the general reconstruction scheme we obtain the power law cosmology model for the $$f(R,R_{\mu \nu }R^{\mu \nu })=R+d(R_{\mu \nu }R^{\mu \nu })^p$$

f

(
R
,

R

μ
ν

R

μ
ν

)

=
R
+
d

(

R

μ
ν

R

μ
ν

)

p

case as well as the model that describes symmetric bounce. Moreover, we reconstruct model, unifying both matter dominated and accelerated phases, where ordinary matter is neglected. Using inverted reconstruction scheme we recover specific $$f(R,R_{\mu \nu }R^{\mu \nu })$$

f
(
R
,

R

μ
ν

R

μ
ν

)

function which give rise to the de-Sitter evolution. Finally, by employing the perfect fluid approach, we demonstrate that this model can realize inflation consistent with the bounds coming from the BICEP2/Keck array and the Planck data. We also discuss the holographic dark energy density in terms of the presented $$f(R,R_{\mu \nu }R^{\mu \nu })$$

f
(
R
,

R

μ
ν

R

μ
ν

)

theory. Thus, it is suggested that the introduced extension of the mimetic regime may describe any given cosmological model.
Combined effect of nitrogen-doped functional groups and porosity of porous carbons on electrochemical performance of supercapacitors
Authors: Ilnicka Anna , Skorupska Malgorzata , Szkoda Mariusz , Zarach Zuzanna , Kamedulski Piotr , Zielinski Wojciech , Lukaszewicz Jerzy P. 
Published: September 2021

AbstractIn this work, nitrogen-doped porous carbons obtained from chitosan, gelatine, and green algae were investigated in their role as supercapacitor electrodes. The effects of three factors on electrochemical performance have been studied—of the specific surface area, functional groups, and a porous structure. Varying nitrogen contents (from 5.46 to 10.08 wt.%) and specific surface areas (from 532 to 1095 m2 g−1) were obtained by modifying the carbon precursor and the carbonization temperature. Doping nitrogen into carbon at a level of 5.74–7.09 wt.% appears to be the optimum for obtaining high electrochemical capacitance. The obtained carbons exhibited high capacitance (231 F g−1 at 0.1 A g−1) and cycle durability in a 0.2 mol L−1 K2SO4 electrolyte. Capacitance retention was equal to 91% at 5 A g−1 after 10,000 chronopotentiometry cycles. An analysis of electrochemical behaviour reveals the influence that nitrogen functional groups have on pseudocapacitance. While quaternary-N and pyrrolic-N nitrogen groups have an enhancing effect, due to the presence of a positive charge and thus improved electron transfer at high current loads, the most important functional group affecting energy storage performance is graphite-N/quaternary-N. The study points out that the search for the most favourable organic precursors is as important as the process of converting precursors to carbon-based electrode materials.
A scanning dynamic collimator for spot-scanning proton minibeam production
Authors: Sotiropoulos Marios , Prezado Yolanda 
Published: September 2021

AbstractIn proton minibeam radiation therapy, proton minibeams are typically produced by modulating a uniform field using a multislit collimator. Multislit collimators produce minibeams of fixed length and width, and a new collimator has to be manufactured each time a new minibeam array is required, limiting its flexibility. In this work, we propose a scanning dynamic collimator for the generation of proton minibeams arrays. The new collimator system proposed is able to produce any minibeam required on an on-line basis by modulating the pencil beam spots of modern proton therapy machines, rather than a uniform field. The new collimator is evaluated through Monte Carlo simulations and the produced proton minibeams are compared with that of a multislit collimator. Furthermore, a proof of concept experiment is conducted to demonstrate the feasibility of producing a minibeam array by repositioning (i.e. scanning) a collimator. It is concluded that besides the technical challenges, the new collimator design is producing equivalent minibeam arrays to the multislit collimator, whilst is flexible to produce any minibeam array desired.
Past environmental changes affected lemur population dynamics prior to human impact in Madagascar
Authors: Teixeira Helena , Montade Vincent , Salmona Jordi , Metzger Julia , Bremond Laurent , Kasper Thomas , Daut Gerhard , Rouland Sylvie , Ranarilalatiana Sandratrinirainy , Rakotondravony Romule , Chikhi Lounès , Behling Hermann , Radespiel Ute 
Published: September 2021

AbstractQuaternary climatic changes have been invoked as important drivers of species diversification worldwide. However, the impact of such changes on vegetation and animal population dynamics in tropical regions remains debated. To overcome this uncertainty, we integrated high-resolution paleoenvironmental reconstructions from a sedimentary record covering the past 25,000 years with demographic inferences of a forest-dwelling primate species (Microcebus arnholdi), in northern Madagascar. Result comparisons suggest that climate changes through the African Humid Period (15.2 – 5.5 kyr) strongly affected the demographic dynamics ofM. arnholdi. We further inferred a population decline in the last millennium which was likely shaped by the combination of climatic and anthropogenic impacts. Our findings demonstrate that population fluctuations in Malagasy wildlife were substantial prior to a significant human impact. This provides a critical knowledge of climatically driven, environmental and ecological changes in the past, which is essential to better understand the dynamics and resilience of current biodiversity.
A top-down approach making cellulose carbonaceous aerogel/MnO2 ultrathick bulk electrodes with high mass loading for supercapacitors
Authors: Zhang Weiye , Li Yanchen , Wang Beibei , Sun Jingmeng , Lin Lin , Liu Yi , Guo Hongwu 
Published: September 2021

A cellulose carbonaceous aerogel/MnO2 ultrathick electrode with a unique low curvature, porous carbon thin-walled tube array structure was obtained from natural wood using a simple top-down approach.
Bimodal Fitting and Bilateral Cochlear Implants in Children With Significant Residual Hearing: The Impact of Asymmetry in Spatial Release of Masking on Localization
Authors: Sparreboom Marloes , Ausili Sebastián , Agterberg Martijn J. H. , Mylanus Emmanuel A. M. 
Published: September 2021

Purpose
This study aimed to gain more insight into the primary auditory abilities of children with significant residual hearing in order to improve decision making when choosing between bimodal fitting or sequential bilateral cochlear implantation.

Method
Sound localization abilities, spatial release of masking, and fundamental frequency perception were tested. Nine children with bimodal fitting and seven children with sequential bilateral cochlear implants were included in the study. As a reference, 15 children with normal hearing and two children with simultaneous bilateral cochlear implants were included.

Results
On all outcome measures, the implanted children performed worse than the normal hearing children. For high-frequency localization, children with sequential bilateral cochlear implants performed significantly better than children with bimodal fitting. Compared to children with normal hearing, the left–right asymmetry in spatial release of masking was significant. When the implant was hindered by noise, bimodally fitted children obtained significantly lower spatial release of masking compared to when the hearing aid was hindered by noise. Overall, the larger the left–right asymmetry in spatial release of masking, the poorer the localization skills. No significant differences were found in fundamental frequency perception between the implant groups.

Conclusions
The data hint to an advantage of bilateral implantation over bimodal fitting. The extent of asymmetry in spatial release of masking is a promising tool for decision making when choosing whether to continue with the hearing aid or to provide a second cochlear implant in children with significant residual hearing.