bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of HSD17B13 rs72613567: TA Allelic Variant With Liver Disease: Review and Meta-Analysis
Authors: Tang Shan , Zhang Jing , Mei Tingting , Zhang Wenyan , Zheng Sujun , Yu Haibin 
Published: January 2021

Abstract
AIM: To assess the association of HSD17B13 rs7261356:TA allelic variant with liver disease, we performed the current review and meta-analysis. METHODS: 5 studies were identified by a search of CNKI,CBM,MEDLINE, PubMed, EMBASE, and CENTRAL databases from inception to April 2020. Odds ratios (ORs) with 95% confidence interval (CI) were calculated using random effects model or fixed effects model based on the between-study heterogeneity.The Stata 12.0 software was employed for data analysis.RESULTS: Statistical analysis showed that the HSD17B13 rs7261356:TA allelic variant was associated with HCC compared with CLD (TA vs T OR=0.766, 95% CI=0.682-0.860, P=0.000) or healthy controls(TA vs T OR=0.649, 95% CI=0.431-0.977, P=0.038). But the HSD17B13 rs7261356:TA allelic variant was not associated with NAFLD compared with non-NAFLD(TA vs T OR=0.749, 95% CI=0.517-1.804, P=0.126).Egger’s test revealed no significant publication bias. Conclusion: The present findings suggest HSD17B13 rs7261356:TA allelic variant was association with HCC risk in the entire population studied.
Modern Contraceptive Use Among Women in Need of Family Planning in India: an Analysis of the Inequalities Related to the Mix of Methods Used
Authors: Ewerling Fernanda , McDougal Lotus , Raj Anita , Ferreira Leonardo Z. , Blumenberg Cauane , Parmar Divya , Barros Aluisio J. D. 
Published: January 2021

Abstract
ObjectiveTo evaluate the type of contraceptives used by women in need of family planning in India and the inequalities associated with that use according to women's age, education, wealth, subnational region of residence and empowerment level.MethodsUsing data from the Indian National Family and Health Survey-4 (2015-16), we evaluated the proportion of partnered women aged 15-49 years with demand for family planning satisfied (DFPS) with modern contraceptive methods. We also explored the share of each type of contraception (short- [e.g., condom, pill] and long-acting [i.e., IUD] reversible contraceptives and permanent methods) and related inequalities.ResultsThe majority (71.8%; 95% CI: 71.4 - 72.2) of women in need of contraception were using a modern method, most (76.1%) in the form of female sterilization. Condom and contraceptive pill were the second and third most frequently used methods (11.8% and 8.5%, respectively); only 3.2% reported IUD. There was a nearly linear exchange from short-acting to permanent contraceptive methods as women aged. Women in the poorest wealth quintile had DFPS with modern methods at least 10 percentage points lower than other women. We observed wide geographic variation in DFPS with modern contraceptives, ranging from 23.6% (95% CI: 22.1 – 25.2) in Manipur to 93.6% (95% CI: 92.8 – 94.3) in Andhra Pradesh. Women with more accepting attitudes towards domestic violence and lower levels of social independence had higher DFPS with modern methods but also had higher reliance on permanent methods. Among sterilized women, 43.2% (95% CI: 42.7 – 43.7) were sterilized before age 25, 61.5% (95% CI: 61.0 – 62.1) received monetary compensation for sterilization, and 20.8% (95% CI: 20.3 – 21.3) were not informed that sterilization prevented future pregnancies.ConclusionIndian family planning policy should prioritize women-centered care, making reversible contraceptive methods widely available and promoted.
DEM Resolutions for Landslide Susceptibility Modeling
Authors: Wubalem Azemeraw 
Published: January 2021

Abstract
In landslide susceptibility mapping, the digital elevation model (DEM) is one of the most essential data sets, which is frequently used. Therefore, evaluate the effects of the spatial resolution of DEM on the landslide susceptibility model is very important. Hence, this paper is analyzed only the effects of the spatial resolution of DEM, Advanced Spaceborne Thermal Emission, and Reflection (ASTER) was used for DEM data source. The ASTER DEM was resampled to 45, 60, 75, and 90 m spatial resolutions. A set of geodatabases were built using Geographic Information System (GIS), which contains landslide governing factors and landslide inventory. Frequency ratio (FR) and certainty factor (CF) statistical methods were employed to generate a landslide susceptibility map. Landslide density and area under the curve (AUC) were applied to evaluate the model's performance for each DEM resolution. The results of the predictive rate curve value of AUC showed a coarser DEM resolution (90 m) produced the best performance and prediction accuracy. This indicated that a coarser DEM resolution produced higher predictive accuracy than fine resolution. Concerning the statistical models, the frequency ratio model produced very good accuracy at the coarser DEM resolutions (75 and 90 m). The predictive rate curve value of AUC ranges from 86–92% for the FR model and 81–89% for the CF model which indicating very good accuracy of the models to predict future landslide incidence in the study area. Therefore, it is possible to endorse statistical methods (frequency ratio, and certainty factor) respect with to DEM resolution, is satisfactory to landslide susceptibility mapping.
Freezing Resistance Evaluation of Rose Stems During Frost Dehardening Using Electrical Impedance Tomography
Authors: Qian Ji , Zhou Juan , Gong Juan Rui , Liu Yang , Zhang Gang 
Published: January 2021

Abstract
BackgroundElectrical impedance tomography (EIT) has rarely been applied in plant science, particularly to study plant resistance to abiotic and biotic stresses. In this study, we evaluated the freezing resistance of floribunda roses (Rosa Floribunda) during frost dehardening using the EIT technique to identify a new method for rapid and non-destructive measurement of plant freezing resistance.ResultsThe current was the excitation source, the boundary voltage value was measured, and then the boundary voltage reconstructed value was formed. Using an imaging algorithm, the two-dimensional (2D) distribution of impedance or impedance variation was reconstructed. The EIT reconstructed values decreased obviously with the decline in freezing temperatures. The EIT reconstructed values of stems had the best fit to the logistic equation, and subsequently, the semi-lethal temperatures were calculated. The freezing resistance results evaluated using EIT reconstructed values were linearly correlated with the results of the traditional electrolyte leakage (EL) method (r=0.93, P<0.01).ConclusionsIn conclusion, after freezing tests, the reconstructed values of EIT images could be used to quantitatively evaluate the freezing resistance of floribunda rose stems. The present study provides a reference for the further application of the EIT technique for non-destructive and rapid detection of plant freezing resistance.
The effect of NLRP3 on tumors based on pan-cancer research
Authors: Tang Desheng , Li Wei , Xu Zhengjie , Jiang Suxiao , Fang Kun 
Published: January 2021

Abstract
NLRP3 is a multi-protein complex in cells, which can directly or indirectly affect the tumor microenvironment and participate in tumor growth, invasion and metastasis. Tumor and normal tissue gene sequencing was downloaded, clinical and mutation-related data was obtained from the TCGA website, and Kaplan-Meier and cox regression analysis was used to analyze the relationship between NLRP3 and overall survival (OS) as well as Hazard ratio (HR). The correlation between NLRP3 and tumor microenvironment score, immune cell invasion, and immune resistance indicators (tumor mutation burden and microsatellite instability) was performed. Finally, the function of NLRP3 in tumors was analyzed by GSEA.Inflammation is one of the important factors that cause cancer.
Anxiety is associated with undesirable eating behaviors in university students during the COVID-19 pandemic
Authors: Coakley Kathryn E , Le Huyen , Silva Spirit Rae , Wilks Aspen 
Published: January 2021

Abstract
Background

COVID-19 has impacted mental health globally, however, relationships between anxiety and eating behaviors during the pandemic have not been explored. This study evaluated anxiety, eating attitudes and behaviors, and associations between anxiety and eating behaviors in students at a large public University in the United States during the COVID-19 pandemic.
Methods

Current undergraduate and graduate/professional students completed a cross-sectional survey in fall 2020. Demographic information, indicators of anxiety in the past two weeks assessed by the Generalized Anxiety Disorder Screener (GAD-7), and eating behaviors assessed by the Adult Eating Behavior Questionnaire (AEBQ) were evaluated. A score ≥ 10 on the GAD-7 indicated anxiety (≥ 15 indicated severe anxiety). Eating behaviors were reported via Likert scale and combined into eight AEBQ subscales; subscale mean and standard deviation were reported. Differences in mean AEBQ subscale scores were examined between participants with and without anxiety via Mann-Whitney U tests. Multivariate linear regression was utilized to examine associations between GAD-7 score and individual AEBQ subscale scores, adjusting for age, gender, race/ethnicity, and student status.
Results

The final sample included 1243 students (57% undergraduates). In the full sample, 51.9% experienced anxiety in the past two weeks; 24.6% had severe anxiety. Subgroups with the highest prevalence of anxiety included non-cisgender participants (73.6%), the youngest age group [18–20 years of age (62%)], undergraduate students (60.7%), and Hispanic/Latino participants (57.5%). Participants with anxiety had significantly lower AEBQ scores for enjoyment of food and significantly higher scores for emotional over and under-eating, food fussiness, food and satiety responsiveness, and hunger than those with no anxiety (p < 0.01). In adjusted analyses, GAD-7 score was significantly and positively associated with hunger, food responsiveness, emotional over-eating, satiety responsiveness, and food fussiness and negatively associated with enjoyment of food.
Conclusions

The prevalence of anxiety is overwhelming in undergraduate and graduate/professional students amidst the COVID-19 pandemic. Eating behaviors differ significantly in those with anxiety; increasing anxiety severity was associated with undesirable eating behaviors including hunger and emotional over-eating. Universities and health professionals must consider strategies to address anxiety, particularly in younger students, non-cis-gender students, and across race/ethnicities keeping in mind associations between anxiety and eating behaviors.
Comparing the Effectiveness of Risperidone with Aripiprazole as a Combination Therapy in Attention-Deficit Hyperactivity Children with Oppositional Defiant Disorder
Authors: Yousefi Fayegh , Gheshlagh Reza Ghanei , Moghadam Abbas Saremi , Mohammadzadeh Soleiman , Rezaei Farzin , Hassanzadeh Kambiz , Tahazade Somayeh 
Published: January 2021

Abstract
Background: This study intends to compare the effectiveness of Risperidone with Aripiprazole as a combination therapy in Attention-deficit hyperactivity (ADHD) children with oppositional defiant disorder, treated with Methylphenidate. Methods: This is a double-blind clinical experiment. The sample size was determined as 60 (40 for the intervention group and 20 for the control group) by random sampling. The data collecting instrument was Parent's ADHD Rating Scale, Clinical Global Impression-Severity (CGI-S), demographic information checklist, and drug's side-effects checklist for this study. Repeated measurement multivariate analysis was used as a statistical method to compare the quantitative variables in both intervention and control groups using SPSS18 software. Results: The results of this study indicated that there is a substantial difference between scores in ADHD and oppositional defiant disorder (ODD) groups after 8 weeks (F=2.34, p>0.03). Conclusion: Based on the results of the present study, Aripiprazole in combination with Methylphenidate have a higher effect on reducing ADHD and ODD symptom.Trial registration: IRCT20160530028182N5; Registered 6 February 2018, https://en.irct.ir/trial/22916
Prevalence and Risk Factors For Retinopathy of Prematurity Among Infants in Minilk-II Hospital, Addis Ababa, Ethiopia: A Retrospective Cross-Sectional Study, 2020.
Authors: Woldemariam Emebet Berhane , Aliyou Hana Endale , Redi Yosef Tsige 
Published: January 2021

Abstract
Background: Retinopathy of prematurity (ROP) is defined as a vaso-proliferative retinal disorder that leads to childhood blindness; and persists as the main cause of preventable childhood blindness. The impact of ROP in developing countries is heavier as term infants can develop ROP because of inadequate awareness of the disease development and the risk factors. Hence, the aim of the study is assessing the prevalence and risk factors for retinopathy of prematurity in the specific study area.Methodology: An institutional based cross-sectional retrospective study was conducted on 301 samples of the pediatrics out-patient eye clinic medical records, at Minilik II referral hospital, from March to April 2020. Study subjects were selected using systematic random sampling method. Data was collected from medical records of all infants visiting the hospital for eye problems from January 2018 to December 2019, using a structured check list. The collected data was entered and cleaned using Epi data 6.4.2.0 and then exported & analyzed using SPSS version 25. Bivariate and multivariate analysis was computed to distinguish the statistically significant factors. Result: The prevalence of ROP among infants in this study showed 39(13%). Of these, more than half (56.4%) were Zone II + Stage 1, followed by Zone II + stage-2, and Stage-5; 12.8% and 10.2% respectively. Birth weight, oxygen therapy and sepsis were the factors significantly associated with ROP [AOR= 39.28; 95% CI: 3.204- 481.658], [AOR= 5.317; 95% CI:1.009- 28.019] and [AOR=9.805; 95% CI:1.592- 60.388] respectively. Conclusions: the prevalence of ROP in the current study is (13%). Birth weight, oxygen therapy and sepsis were the determinant risk factors for development of ROP. Regular ANC, and maternal education may be important to reduce the risk of low-birth weight, and sepsis that results in long-term oxygen therapy leading to childhood blindness.
The Efficacy of Mootral Supplementation on Methane Production and Rumen Fermentation Characteristics in Ruminants Fed Different Styles
Authors: Ahmed Eslam , Fukuma Naoki , Hanada Masaaki , Nishida Takehiro 
Published: January 2021

Abstract
Background: Using natural feed supplements to mitigate methane emissions from ruminants is a promising strategy. Many antimethanogenic compounds have been used to alter rumen fermentation, yet their potential to reduce methane production effectively is not consistent across different kinds of feeding styles (forage:concentrate ratios). Therefore, this study was conducted to investigate the impacts of Mootral (MT), a natural combination of garlic powder and bitter orange extract, on methane production, rumen fermentation, and digestibility in different feeding models commonly used for ruminants. The dietary treatments were 1000 g grass/kg ration (10 GRS), 8 GRS + 200 g concentrate/kg ration (2CON), 6GRS + 4CON, 4GRS + 6CON, and 2GRS + 8CON. MT was supplemented at 200 g/kg of the feed. Each group consisted of 6 replicates. The experiment was performed as a batch culture for 24 h at 39 °C. This procedure was repeated in 3 consecutive runs. Results: The results of this experiment showed that supplementation with MT strongly reduced methane production in all kinds of feeding models (P<0.001). Its efficacy in reducing methane/digestible dry matter was 44% in the 10GRS diet, and this reductive power increased with the inclusion of CON up to a 69.5% reduction with the 2GRS + 8CON diet. MT application significantly increased gas and carbon dioxide production and the concentration of ammonia-nitrogen, but decreased the pH (P<0.001). In contrast, it did not interfere with organic matter and fiber digestibility. Supplementation with MT was effective in altering rumen fermentation toward less acetate and more propionate and butyrate. Additionally, it improved the production of total volatile fatty acids in all feeding models (P<0.001). Conclusions: The MT combination showed effective methane reduction by improving rumen fermentation characteristics without exhibiting adverse effects on fiber digestibility. Thus, MT could be used with all kinds of feeding models to effectively mitigate methane emissions from ruminants.
Identification of Key Genes Affecting Porcine Fat Deposition Based on Co-Expression Network Analysis of Weighted Genes
Authors: Xing Kai , Liu Huatao , Zhang Fengxia , Liu Yibing , Shi Yong , Ding Xiangdong , Wang Chuduan 
Published: January 2021

Abstract
Background: Fat deposition is an important economic consideration for pig production. The amount of fat deposition in pigs seriously affects production efficiency, quality, and reproductive performance, while also affecting consumers' choice of pork. Weighted gene co-expression network analysis (WGCNA) has been shown to be effective in pig genetic studies. Therefore, this study aimed to identify modules that co-express genes associated with fat deposition in pigs (Songliao black and Landrace breeds) with extreme levels of backfat (high and low), and to identify the central genes in each of these modules. Results: We used RNA-seq of different pig tissues to construct a gene expression matrix consisting of 12 862 genes from 36 samples. Eleven co-expression modules were identified using WGCNA; the number of genes in these modules ranged from 39 to 3363. We found four co-expression modules were significantly correlated with backfat thickness. A total of 14 genes ( RAD9A , IGF2R , SCAP , TCAP , DGAT1 , GPS2 , IGF1 , MAPK8 , FABP , FABP5 , LEPR , UCP3 , APOF , and FASN ) were found to be related to fat deposition. Conclusions: RAD9A , TCAP , GPS2 , and APOF were found to be the key genes in the four modules according to the degree of gene connectivity. Combining the results of differential gene analysis, APOF was proposed as a strong candidate gene for body size traits. This study explores the key genes that regulate porcine fat deposition and lays the foundation for further research into the molecular regulatory mechanisms behind porcine fat deposition.
A dynamic basal complex modulates mammalian sperm movement
Authors: Khanal Sushil , Leung Miguel , Royfman Abigail , Fishman Emily , Saltzman Barbara , Bloomfield-Gadêlha Hermes , Mordehai Tzvya Zeev Ben , Avidor-Reiss Tomer 
Published: January 2021

Abstract
Reproductive success depends on efficient sperm movement driven by dynein-mediated microtubule sliding in the axoneme 1-3. Models predict sliding at the base of the tail – the centriole – but such sliding has never been observed 4,5. Centrioles are evolutionarily-ancient organelles with a conserved architecture 6-8, and their rigidity is thought to restrict microtubule sliding 1. Here, we show that, in mammalian sperm, the atypical distal centriole (DC) and its surrounding atypical pericentriolar matrix 9,10 form a dynamic basal complex (DBC) that facilitates a cascade of internal sliding deformations, coupling tail beating with asymmetric head kinking. During asymmetric tail beating, the DC’s right side and its surroundings slide ~300 nm rostrally relative to the left side. This deformation is transmitted through the DBC to the head-tail junction; as a result, the head tilts to the left, generating a kinking motion. These findings suggest that the DBC evolved to act as a mechanotransducer, coupling sperm head and tail into a single self-coordinated system. The DBC may act as a morphological computer 11, regulating tail beating from external feedback imparted to the head during sperm navigation. We anticipate our findings will enable studies of coordinated motion in sperm and cilia in many contexts.
Management of Traumatic Lumbar Meningo-radicular Injury Caused by Foreign Body Penetration using Sling Technique
Authors: Chen Ko-Ting , Chen Ying-Yun , Wu Chieh-Tsai , Chang Ting-Wei 
Published: January 2021

Abstract
BackgroundNon-missile penetrating spinal injuries (NMPSI) can cause delayed neural injury, including cerebrospinal fluid (CSF) leakage and spinal cord herniation, related to dural defects. To repair ventral dural defect (VDD) is particularly challenging in trauma patients and, in a meanwhile, there has been a well-established method: sling technique, used for patients with idiopathic spinal cord herniation (ISCH) in whom VDD being the primary pathology to deal with.Case presentationThis 51-year-old man fell down from an altitude of six meters and landed on a plier. The neurological examination revealed decreased muscle strength (grade 3/3) in bilateral lower extremities. Computed tomography showed a pair of pliers penetrating L4 lamina, spinal canal through vertebral body, psoas muscle into retroperitoneal cavity with inferior vena cava (IVC) indentation. Emergent laparotomy revealed intact IVC with no major organ damage, and the plier was removed from back under direct visualization of IVC. Immediate posterior approach showed a through-and-through VDD. Sling technique with COOK® dura substitute was applied to cover the VDD and fixed with 7-0 prolene after neurolysis. There was no CSF leakage or nerve tissue herniation afterward. He regained working ability with full muscle strength except for a minor sequal of paresthesia of right toe.ConclusionsIn patients with NMPSI with VDD, indirect duraplasty using sling technique originally developed for treating patients with ISCH is suitable and effective in preventing CSF leakage and delayed neural injury. We further propose an algorithm emphasizing key decision makings for repairing dural defect while preventing delayed neural injury.
Epidemiology of Traumatic Spinal Cord Injuries in Colombia
Authors: Giraldo Yalisma Andrea , Castro José Luis , Tovar-Sanchez Maria Ana , Kumar Annora A. , Pacichana-Quinayaz Sara G. , Bonilla-Escobar Francisco J. 
Published: January 2021

Abstract
Study Design: Retrospective cohort study.Objectives: To determine the incidence and characteristics of newly injured individuals admitted to a traumatic spinal cord injury (TSCI) referral center during a 4-year period.Setting: University Hospital of Valle, Cali, Colombia.Methods: Individuals were identified, and their data was recorded based on the International Spinal Cord Injury Core Data Set. The outcome of interest was the American Spinal Injury Association Impairment Scale (AIS) grade at last follow-up.Results: There were 491 individuals admitted in the 4-year period. The mean annual incidence of TSCI was 56.27 per million inhabitants. Considering TSCI in individuals exclusively from Cali, the mean annual incidence was 27.78 per million. The leading cause of TSCI was interpersonal violence (47.25%) and falls (33.60%). There was a 96.52% (p<0.0001) correlation between AIS grade at admission and last follow-up. The most common AIS grade at last follow-up was E (34.01%) caused mostly by falls (57.48%), followed by A (31.16%) caused mostly by interpersonal violence (76.27%). The reported employment rate dropped from 75.56% to 18.94% before and after TSCI (p<0.05). AIS grade A was associated with more post-injury complications (p<0.05).Conclusions: This is the first cohort study in Colombia describing the incidence and AIS grades of individuals with TSCI from a trauma referral center. Interpersonal violence was overrepresented in this population. Future research should include the evaluation of prevention strategies, as well as research on interventions towards quality improvement in patient care and post discharge services especially for individuals with AIS grade A.