bluuebunny/crossref_metadata_2025_split huggingface dataset:
High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle?
Authors: Thomazini Fernanda , de Carvalho Beatriz Silva , de Araujo Priscila Xavier , Franco Maria do Carmo 
Published: July 2021

Abstract

Objectives
The prevalence of hyperuricemia, a common disorder, has been increasing. Moreover, the association between obesity, serum uric acid levels, and cardiometabolic markers in children is unclear. Therefore, this study aimed to analyze the inter-relationships between these factors in a sample of children aged 6–12 years.

Methods
We evaluated 764 children and stratified them according to their body mass index (BMI). Blood pressure and uric acid, creatinine, lipid, and glycemic profiles were evaluated, and the estimated glomerular filtration rate (eGFR) and the homeostatic model assessment for insulin resistance (HOMA-IR) index were calculated.

Results
There was a significant linear trend of increasing systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol, low-density lipoprotein cholesterol (LDLc), uric acid, insulin levels, and HOMA-IR index values corresponding with overweight and obese groups; however, high-density lipoprotein cholesterol (HDLc) levels decreased with increasing obesity. The mean creatinine level and eGFR were similar across all BMI groups. Uric acid levels were significantly correlated with BMI (r=0.527), waist circumference (r=0.580), SBP (r=0.497), DBP (r=0.362), TG (r=0.534), total cholesterol (r=0.416), LDLc (r=0.286), HDLc (r=−0.248), insulin (r=0.613), and HOMA-IR index (r=0.607). Multiple regression analyses showed that BMI (B=0.071; SE=0.012; p<0.001), TG (B=0.004; SE=0.001; p<0.001), LDLc (B=0.003; SE=0.001; p=0.006), and insulin (B=0.066; SE=0.007; p<0.001) (R2=0.460) were significant predictors of increased uric acid levels and explained 46% of the variability in uric acid in these children.

Conclusions
Our findings suggest that overweight or obese children are more likely to have higher uric acid levels. Moreover, several cardiometabolic risk factors were strongly associated with high uric acid levels.
Idiopathic juvenile osteoporosis in a child: a four-year follow-up with review of literature
Authors: Dabas Aashima , Malhotra Rakhi , Kumar Ravindra , Khadgawat Rajesh 
Published: July 2021

Abstract

Objectives
Childhood osteoporosis is an uncommon condition that usually develops secondary to underlying disease states. Idiopathic juvenile osteoporosis or early onset osteoporosis is a rare cause of primary osteoporosis in childhood associated with mutations in “bone fragility” genes.

Case presentation
The index case presented with upper back pain and was detected to have multiple vertebral fractures. Further workup for the cause revealed a homozygous benign mutation in low-density lipoprotein receptor-related protein 5, which was also detected in the mother who remained asymptomatic till presentation. The child was successfully treated with intravenous zoledronate.

Conclusions
The case report describes the management approach and four-year follow-up of the child.
Augmented Reality for Supporting Adult-child Shared Reading
Authors: ChanLin Lih-Juan 
Published: July 2021

Abstract
Augmented reality (AR) stories offer a new opportunity for parents and teachers at libraries and schools to explore electronic stories. Embedded with multimedia design, AR allows diverse paths of exploration in the story contexts for shared story-reading experiences among parents and children. In this study, parents in the reading community (a library and a school) were provided with AR guided support and a skill-building activity. Observations and in-depth interviews were conducted to collect qualitative data. Inductive analysis was used to summarize the findings. Results of the study were summarized in the following themes: Prior adult-child reading experiences; Novelty with AR reading; Parents’ scaffolding for using AR; Interactive reflective thinking from AR reading; Positive responses from learning of shared reading; and Parents’ suggestions and concerns. It was observed that the AR reflective reading approach encouraged parents to play an active role in guided reading. Children and parents were positive about their active participation in the AR-mediated exploratory reading context. With the AR guided support and skill-building activity, parents applied the scaffolded-reading skills in the AR reading intervention. The AR-mediated reading approach is promising and open to more dynamic design of interactive features.
Basque impersonals in comparison
Authors: Fernández Beatriz , Berro Ane 
Published: July 2021

AbstractThe Basque impersonal is a detransitivized construction that resembles middles, passives and impersonals. In this construction, the thematic object is the grammatical subject, which bears absolutive case and triggers absolutive agreement, and the auxiliary selected isizan‘be’. At the same time, there is an implicit agent that is syntactically active even though it is not realized as an ergative argument with corresponding ergative agreement. In this article, we compare the Basque impersonal with the middle, the passive of languages like English, and subject-suppressing impersonals (as in Polish), and we show that it is more similar to the passive and subject-suppressing impersonals, given that (i) in the Basque impersonal, the event is instantiated, (ii) it can be used with more predicate classes, and (iii) it allows dative-marked second objects, among other properties. Similarly, like in English-type passives and subject-suppressing impersonals, the implicit agent of the Basque impersonal is syntactically active, as it can license agent-oriented modifiers and control adjunct purpose clauses. Nevertheless, there are other properties in which these constructions differ; for instance, the implicit agent must be interpreted as human, unlike in passives, and the grammatical subject cannot be other than 3rd person, something attested neither in passives nor in subject-suppressing impersonals. In light of this distribution, we consider the Basque impersonal to be located somewhere in between middles, passives and subject-suppressing impersonals as far as its syntactic properties are concerned.
Singing and the body: body-focused and concept-focused vocal instruction
Authors: Szczepek Reed Beatrice 
Published: July 2021

Abstract
The body is the singer’s musical instrument, and therefore it is impossible to teach singing without the instructor involving their own and the learner’s body in the process of instruction. The teacher’s challenge is to communicate physical skills but also artistic, musical and vocal concepts. The body is centrally involved in the performance of both; however, an analysis of vocal instruction shows that teachers differentiate between learning goals, or ‘learnables’, which they treat as primarily embodied (body-focused instruction) and learnables they treat as primarily conceptualised (concept-focused instruction). When teaching learnables as embodied skills, instructors foreground the body. They do so by referring to the body explicitly and using their own body for demonstrations. They also depict internal physical processes, manipulate the student’s body through touch, share the student’s embodied stance, make use of physical objects as tools for practicing skills and orient to the student’s body as visually assessable. In concept-focused instruction, teachers foreground mental engagement with concepts rather than the embodied aspects of their execution, even though embodied skills are required to perform the learnables in question. They do so by referencing concepts explicitly, demonstrating how the piece should be sung and physically depicting emotional states and musical concepts.
Monitoring and evaluating body knowledge: metaphors and metonymies of body position in children’s music instrument instruction
Authors: Stevanovic Melisa 
Published: July 2021

AbstractThis paper examines music instrument teachers’ instructive use of noun metaphors and metonymies of behaviors related to the playing and handling of a musical instrument. Drawing on 10 video-recorded 30–40 min-long instrument lessons as data, and conversation analysis as a method, the paper examines the temporal location of these figurative turns (i.e., instruction turns including a noun metaphor or metonymy) within the instructional activities and in relation to the student’s behaviors. At the beginning of a new instructional sequence, a figurative turn allows the teacher to test and monitor the level of student’s knowledge, while the student orients to a need to demonstrate that knowledge. Figurative turns also enable the teacher to initiate correction in complex movement sequences, its organization as a series of metaphors or metonymies enabling an easy return to an earlier point in a sequence. Furthermore, the flexibility of metaphors and metonymies as interactional resources is evidenced by the ease by which a figurative instruction turn may be transformed into an affirmative evaluation of student conduct. The paper thus suggests that instructing body knowledge through metaphors and metonymies has significant pedagogical advantages, also providing a detailed account for why and how this is the case.
Situating embodied instruction – proxemics and body knowledge
Authors: Reed Darren James 
Published: July 2021

Abstract
In various ways the movement and experience of the body is instructed by others. This may be in the dance class or on the playing field. In these interactions, one person claims knowledge of the other’s body and rights to instruct how that body functions, moves, and feels. By undertaking a close analysis of embodied and spoken interaction within performance training sessions from a multimodal conversation analytic perspective, this paper will identify one kind of broad sequential trajectory – from intimate contact to public display - that shows how an instructor claims rights over the internal workings of another’s body by traversing different levels of proximity and sensorial modalities.
Instructing embodied knowledge: multimodal approaches to interactive practices for knowledge constitution
Authors: Ehmer Oliver , Brône Geert 
Published: July 2021

Abstract
In the introduction to the special issue on ‘Instructing embodied knowledge’, we present a general orientation into this growing field of research, providing the relevant background for the individual contributions. The starting point for the endeavor is the basic observation that practical knowledge or ‘knowing-how’ is typically of a procedural, implicit and embodied nature rather than explicit-conceptual. Given this specific nature, we highlight the fact that for transmitting this type of knowledge, instructors make use of specific multimodal practices that are adjusted to these characteristics. The notion of instructional practice furthermore emphasizes that instructing embodied knowledge is a highly collaborative process between learners and their instructors. In order to provide a broad take on the phenomenon, we review both social-interactional as well as cognitive approaches to embodied knowledge and discuss how the procedural and intercorporeal nature of this knowledge may challenge different views. Independent of the specific approach that is chosen, any account of the construction/instruction of embodied knowledge should emphasize that it is essentially (i) a social activity, (ii) involving the deployment of different semiotic resources, and (iii) using different techniques and devices, such as descriptions, directives and demonstrations. Based on a review of the literature and on the papers in the special issue, we identify a set of key questions that may help to shape the agenda for future studies in the field. The questions relate to the temporal-sequential organization of instructions, the continuum between demonstrations and performances, and the relationship between perceptual access, sensation and the acquisition of embodied knowledge.
Refinements of quantum Hermite-Hadamard-type inequalities
Authors: Budak Hüseyin , Khan Sundas , Ali Muhammad Aamir , Chu Yu-Ming 
Published: July 2021

Abstract
In this paper, we first obtain two new quantum Hermite-Hadamard-type inequalities for newly defined quantum integral. Then we establish several refinements of quantum Hermite-Hadamard inequalities.
Inhomogeneous conformable abstract Cauchy problem
Authors: Rabhi Lahcene , Al Horani Mohammed , Khalil Roshdi 
Published: July 2021

Abstract
In this paper, we discuss the solution of the inhomogeneous conformable abstract Cauchy problem. The homogeneous problem is also studied. The analysis of conformable fractional calculus and fractional semigroups is also given. Existence, uniqueness and regularity of a mild solution for the conformable abstract Cauchy problem are studied. Applications illustrating our main abstract results are also given.
Redetermination of the crystal structure of 3-bromonitrobenzene at 200 K, C6H4BrNO2 – temperature effects on cell constants
Authors: Manana Pholani , Hosten Eric C. , Betz Richard 
Published: July 2021

Abstract
C6H4BrNO2, orthorhombic, Pna21 (no. 33), a = 21.3992(17) Å, b = 5.9311(4) Å, c = 5.2923(4) Å, V = 671.70(9) Å3, Z = 4, R

gt
(F) = 0.0284, wR

ref
(F
2) = 0.0708, T = 200(2) K.
Crystal structure of 3-allyl-4-(2-bromoethyl)-5-(4-methoxyphenyl)-2-(p-tolyl)furan, C23H23BrO2
Authors: Xu Xue-Li , Li Jihong 
Published: July 2021

Abstract
C23H23BrO2, monoclinic, P21/c (no. 14), a = 24.193(4) Å, b = 5.8614(10) Å, c = 13.873(3) Å, β = 93.168(3)∘, V = 1964.3(6) Å3, Z = 4, R

gt
(F) = 0.0316, wR

ref
(F
2) = 0.0915, T = 296(2) K.
A Very Early “Fashion”: Neolithic Stone Bracelets from a Mediterranean Perspective
Authors: Martínez-Sevilla Francisco , Baysal Emma L. , Micheli Roberto , Ifantidis Fotis , Lugliè Carlo 
Published: July 2021

AbstractRing-shaped objects, used mainly as bracelets, appear in the archaeological record associated with the first farming societies around the Mediterranean area. These bracelets, among other personal ornaments, are related to the spread of the farming economy in the Mediterranean (10th–6th millennium BC). In particular, stone bracelets, given their intricate technology, are linked with the early stages of craft specialization and the beginnings of complex social organization. Likewise, their frequency in Early Neolithic assemblages and the lithologies in which they were made have become an important element in the study of the circulation networks of goods, as well as the symbolic behaviors and aesthetic preferences of the first farming groups. This research provides the first overview of the stone bracelets of Neolithic groups in the Mediterranean. We compare the similarities and differences among these ornaments in different geographical zones across the region including Turkey, Greece, Italy, and Spain. Using all the information available about these ornaments – chronology, typology, raw materials and manufacturing processes, use-wear, repair, and alteration practices – we shed light on a complex archaeological trans-cultural manifestation related to the spread of the Neolithic lifestyle across the European continent.
Ceramic Traditions in the Forest-Steppe Zone of Eastern Europe
Authors: Andreev Konstantin Mikhailovich , Vybornov Alexander Alekseevich 
Published: July 2021

Abstract
Early pottery on the territory from the Eastern Caspian Sea and Aral Sea to Denmark reveals a certain typological similarity. It is represented by egg-shaped vessels with an S-shaped profile of the upper part and a pointed bottom. The vessels are not ornamented or decorated with incised lines, organized often in a net. This type of pottery was spread within hunter-gatherer ancient groups. The forest-steppe Volga region is one of the earliest centers of pottery production in Eastern Europe. The first pottery is recorded here in the last quarter of the seventh millennium BC. Its appearance is associated with the bearers of the Elshanskaya cultural tradition. The most likely source of its formation is the territory of Central Asia. Later, due to aridization, these ceramic traditions distributed further westward to the forest-steppe Don region. During the first half of the sixth millennium BC, groups associated with the bearers of the Elshanskaya cultural tradition moved westward. Significant similarities with the ceramic complexes of the Elshanskaya culture are found in materials from a number of early pottery cultures of Central Europe and the Baltic (Narva, Neman, and Ertebølle).
Exploring how people with chronic pain understand their pain: a qualitative study
Authors: Keen Sam , Lomeli-Rodriguez Martha , Williams Amanda C. de C. 
Published: July 2021

Abstract

Objectives
A fundamental principle of pain management is educating patients on their pain using current neuroscience. However, current pain neurophysiology education (PNE) interventions show variable success in improving pain outcomes, and may be difficult to integrate with existing understanding of pain. This study aimed to investigate how people with chronic pain understand their pain, using qualitative exploration of their conceptualisations of pain, and how this understanding accommodated, or resisted, the messages of PNE.

Methods
Twelve UK adults with chronic pain were recruited through advertisements on online pain networks. Semi-structured interviews were conducted remotely, with responses elicited using the Grid Elaboration Method (GEM) and then a PNE article. Participants’ grid elaborations and responses to PNE were analysed using thematic analysis (TA).

Results
Three main themes were extracted from participants' grid elaborations: communicating pain, explaining pain and living with pain. These themes incorporated varied, inconsistent sub-themes: of pain as simultaneously experiential and conceptual; in the body and in the mind; diagnosable and inexplicable; manageable and insuperable. Generalised, meta-level agreement was identified in participants' PNE responses, but with doubts about its practical value.

Conclusions
This study shows that people understand pain through inconsistent experiential models that may resist attempts at conceptual integration. Participants' elaborations showed diverse and dissonant conceptualisations, with experiential themes of restricted living; assault on the self; pursuit of understanding pain and abandonment of that pursuit. Responses, although unexpectedly compatible with PNE, suggested that PNE was perceived as intellectually engaging but practically inadequate. Experiential disconfirmation may be required for behavioural change inhibited by embedded fears and aversive experiences.

Ethical committee number
UCL REC# 17833/003.
Perceptions of Training Pathways from Recent Cardiothoracic Surgery Graduates
Authors: Ward Alison , Ranganath Neel K. , Chen Stacey , Wallen Tyler , Kent Amie J. , Smith III Deane E. , Kon Zachary N. 
Published: July 2021

Background: There are three cardiothoracic surgery (CTS) training pathways—general surgery residency followed by a CTS residency of 2-3 years (traditional), 4 years of general surgery and 3 years of CTS residency (4+3), and an integrated 6-year pathway (I-6). The goal of this study was to survey early career cardiothoracic surgeons regarding their training experiences.
Methods: An email-based survey was sent to cardiothoracic surgeons, who graduated between 2012-2017. Data on training pathway specific variables and overall satisfaction were collected. The primary endpoints were career preparation and satisfaction, scored on a scale from 1-100, 100 being the most positive.
Results: Four hundred seventy-seven emails were sent, with a response rate of 95/477 (20%). Seventy-six of the respondents (80%) were male; the mean age was 39. Seventy-seven (81.0%) completed a traditional training pathway, 7 (7.4%) completed a 4+3 pathway, and 11 (11.6%) completed an I-6 pathway. Participants felt prepared for practice with a mean response of 79.8 (range 31-100); mean career satisfaction was 87.6. When asked which pathway respondents would choose in the current era, 52 (54.7%) would choose a traditional pathway, 17 (17.9%) a 4+3 pathway, and 19 (20.0%) an I-6 program; 7 (7.4%) did not respond. Twenty of 72 (27.8%) traditional pathway trained and 18/18(100%) integrated pathway trained surgeons would choose an integrated pathway.
Conclusions: This is the first survey addressing perceptions of training from early-career cardiothoracic surgeons across all training pathways. Data from this study provides insights to better understand how to improve CTS training for the next generation of surgeons.
CD133+ Stem Cell Therapy Effects on Myocardial Regeneration Through Increased Vascular Endothelial Growth Factor Correlate with Cardiac Magnetic Resonance Imaging Results in Coronary Artery Bypass Graft Surgery Patients with Low Ejection Fraction
Authors: Soetisna Tri Wisesa 
Published: July 2021

Background: Stem cell implantation has become a promising therapy for heart failure due to coronary heart disease (CHD). CD133+ stem cell therapy, together with increases of vascular endothelial growth factor (VEGF) and other growth hormones, can induce myocardial repair.
Objective: To prove that VEGF plays a role in cardiac regeneration.
Methods: Twenty-six patients with CHD and ejection fractions <35% from Harapan Kita Heart and Vascular Center, Jakarta, Indonesia, from 2016 to 2018 were randomized into 2 groups. The treatment group underwent coronary artery bypass graft (CABG) + CD133+ implantation, and the control group underwent CABG only. Six months later, perfusion and myocardial function were assessed by ejection fraction, wall motion score index (WMSI), ventricular dimensions, and scar size using cardiovascular magnetic resonance imaging. VEGF was assessed with enzyme-linked immunosorbent assay.
Results: There was significant improvement in ejection fraction (8.69% ± 9.49% versus 1.43% ± 7.87%, P = .04), WMSI (0.51 ± 0.48 versus –0.01 ± 0.21, P = .003), and scar size (25.46 ± 12.91 versus 27.32 ± 12.92 mm, P = .047) and a significant increase in blood VEGF levels (61.05 ± 63.01 versus 19.88 ± 33.78 pg/mL, P = .01). Improvements in perfusion defects (13.69 ± 5.03 versus 11.53 ± 5.81 P = .32) and ventricular dimensions (–27.59 ± 84.48 versus –19.08 ± 36.79 mm, P = .06) were not statistically significant.
Conclusion: CD133+ stem cell implantation improves myocardial function. The increase in VEGF levels is expected to continue improving restoration of myocardial function when myocardial perfusion improvement is still not optimal.
Penetrasi Dakwah Islamisme Eks HTI di Indonesia:
Authors: As'ad Muhammad 
Published: July 2021

This article seeks to answer a question on how the da’wah activities of former members of Hizbut Tahrir Indonesia (HTI) conducted after its disbandment in 2017. This study used a qualitative method with netnography approach in which participation observation is conducted primarily online. The sample of this research was the social media account of former HTI activist, Felix Siauw and his da’wah team of “Yuk Ngaji”. Findings illustrate that the online da’wah of former HTI members has remained a quite strong and omnipresent on the internet that has similar vision to HTI in which their da’wah activities offer khilafah doctrine. Both Felix Siauw and team of “Yuk Ngaji” utilise the method of da’wah 2.0 which is maximizing visual aesthetics, communication skills, and marketing strategies. As the result, they are quite successful in attracting the millennials to be part of their da’wah movement.