bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gaucher Disease Type 1, A Rare Disease: A Single Center-Experience
Authors: VAROL Fatma İlknur , SELİMOĞLU Ayşe , GÜNGÖR Şükrü , MACİT Bengü 
Published: January 2021

Aim: Gaucher disease is a rare lysosomal storage disease. Enzyme replacement therapy has proven to be very effective in reversing the risk of hepato-splenomegaly, cytopenia, osteopenia and reducing the risk of avasculer osteo necrosis, especially in children and young adults. The aim of this study is to draw attention to this rare disease and increase awareness.
Material and Methods: All medical records of 8 patients diagnosed with Gaucher disease between 2008 and 2020 in our clinic were reviewed.
Result: Five of the cases were female (62.5%), average age at diagnosis; was 7.9 years. When complaints at the time of admission are examined, we found that, 3 patients admitted with swelling in the abdomen, one admitted with abdominal pain, and 4 patients had been referred to our center due to organomegaly detected during the examination. In physical examination 8 patient had splenomegaly. The mean level of glucocerebrosidase enzyme of the patients was found to be 0.61mmol/l/h (normal range of glucocerebrosidase >3.2mmol/l/h). Considering the genetic analysis of the patients, 5 patients had homozygous and 3 patients had heterozygous mutations. One patient with portal hypertension who did not respond to enzyme replacement therapy at the time of admission underwent liver transplant.
Conclusion: Early diagnosis and treatment are important to live with in mind that this disease, which is rare in societies where consanguineous marriage is common and can result in serious morbidity and early death, can be seen more frequently.
La fiesta, momento vital de la praxis intercultural en los jesuitas Ignacio Ellacuría y Francisco Taborda
Authors: Zuchel Lovera Lorena , Achondo Moya Pedro Pablo 
Published: January 2021

The present article shows the contributions of two intellectual Jesuits, Ignacio Ellacuría and Francisco Taborda, who propose the feast or fraternal celebration as an example for a religious interculturality. The text goes from a philosophical proposal, which shows social coexistence as a fundamental, inevitable moment of the living being, to the praxis that makes a mere relationship an experience of recognition and liberation. The study shows the nexus between philosophy and theology, which in many occasions are one single thing in the conceptualization of Latin American traditions. But also, one and indistinguishable discipline, in the case of many Jesuits committed to Our American causes. In particular, we highlight his ideas about the party, a main category in the construction of identity, justice and hope; that, at the same time, are vital moments of reflection and intercultural practice.
L’influenza de la Dialectique des “exercices spirituels” de Saint Ignace de Loyola nel pensiero di Jorge Mario Bergoglio
Authors: Borghesi Massimo 
Published: January 2021

When in October 2016 I started working on my book Jorge Mario Bergoglio. An intellectual biography I did not have the slightest idea of ​​the importance played by the figure and work of Gaston Fessard in the formation of Bergoglio’s thought. There was nothing to suggest that Gaston Fessard could be a relevant author for the intellectual formation of the future Pope. I was struck by the polar and dialectical model of thought that animated him, the possibility of harmonizing opposites, of inviting concepts to a common table that apparently could not be approached, because it places them in a higher plane in which they find their synthesis. This paradigm, of the Church and of the Society of Jesus as complexio oppositorum, finds its verification, according to Bergoglio, in the way in which the Jesuits have achieved the inculturation of the faith in the indigenous peoples of Latin America. Bergoglio rereads Ignatius in the light of a dialectical model. As he will say in one of the interviews he gave me on the occasion of the writing of my book: “In Ignatian spirituality there is always this bipolar tension”. It is certainly an original, uncommon reading of Ignatius’s thought. It is the ideal factor that allows us to explain why Bergoglio, when in 1986 he went to Frankfurt to write his doctoral thesis, chose the Guardinian essay dedicated to the polar opposition. When I concluded my volume on the intellectual biography of the future Pontiff in February 2017, one element, however, remained obscure. Where, from which author had Bergoglio drawn his polar model? Where did your antinomic reading of Ignatian spirituality come from? Not by Guardini discovered philosophically in 1986. Francis indicated the starting point of his intellectual formation. The reading of Fessard’s La dialectique des Exercices spirituels de saint Ignace de Loyola, published in 1956, is the work that “ had a great influence “ on him. It is the work that clarifies Bergoglio’s antinomian thought, his subsequent ideal encounter with Guardini’s philosophy.
O Ponto Ómega de Teilhard de Chardin. Do Contraponto com o Átomo Primitivo de Georges Lemaître à Projeção em Teorias Cosmológicas
Authors: Barbosa João 
Published: January 2021

This article focuses on the Omega Point, an essential concept in Teilhard de Chardin’s evolutionary metaphysics. In certain passages about the Omega Point, Teilhard mentions the primeval atom hypothesis, a theory about the beginning of the universe proposed by Georges Lemaître, another contemporary Jesuit priest who was also a scientist. Although Teilhard and Lemaître are essentially evolutionists, besides being Jesuit priests, their evolutionary metaphysics and their philosophies of science are radically divergent, and two important differences are presented here – about the eventual cosmic determinism and about the relationship between scientific knowledge and religious beliefs. This article also shows how Teilhard’s original concept was projected into two cosmological theories in which it reveals an essential transfiguration by losing its initial anthropic and religious matrix – the cosmological anthropic principle, proposed by physicists John Barrow and Frank Tipler, and the Omega Point Theory proposed later by Frank Tipler.
Association between Consumed Foods and Musculoskeletal Disorder in Office Workers
Authors: Arjmand Golnaz , Irandoost Pardis , Abbaszadeh Mojtaba , Farshad Aliasghar , Salehi Masoud , Shidfar Farzad 
Published: January 2021

Background: Musculoskeletal disorder (MSD) is one of the important problems concerning the staffs' health and productivity in the workplace. Nutritional status and consumption of some foods are also among the determining factors of MSD. So, this study aimed to evaluate the correlation of diet and consumed food groups with MSD.
Methods: This cross-sectional study was conducted on 100 office workers. The participants' anthropometric parameters and their dietary information were collected using a semi-quantitative food frequency questionnaire. The findings were categorized into nine levels. The total scores were calculated for all the items per food group and per person. Nordic musculoskeletal questionnaire was also administered to evaluate the MSD symptoms in nine parts of body.
Results: The score of consumed food groups was compared between individuals “with pain” and “without pain” in nine parts of the body. The scores of fruit intake in individuals “with pain” and “without pain” were 2.94 ± 1.27 vs. 3.29 ± 1.16 and 2.81 ± 1.10 vs. 3.49 ± 1.38 in terms of neck and wrists, respectively. The difference between the two groups were significant (P < 0.05). Furthermore, the participants with pain in the neck consumed significantly lower amounts of cereals and nuts (P = 0.03, 0.04). In the case of the shoulder pain, consuming legumes and nuts in the “without pain” group was higher than the group of participants who had pain (P = 0.01, P = 0.03). Fat intake was higher in the patients who had pain in their hips (P = 0.02).
Conclusion: Less pain was reported in the musculoskeletal system by higher consumption of fruits, nuts, and legumes. It seems that plant-based dietary pattern is more effective in musculoskeletal health.
Nutritional Assessment of Cancer Patients during Chemotherapy in Vasei Hospital of Sabzevar, Iran
Authors: Tofighiyan Tahereh , Kooshki Akram 
Published: January 2021

Background: Malnutrition caused by cancer is a prevalent problem in patients with cancer. This study aimed to evaluate the nutritional status of cancer patients undergoing chemotherapy who referred to Vasei Hospital, Sabzevar, Iran.
Methods: This descriptive-sectional study was conducted on 124 adult patients (older than 18 years of age) with cancer who had referred to the Oncology Ward of Vasei Hospital, Sabzevar, Iran. Followed by obtaining a consent letter and filling out the demographic questionnaire, the participants’ height and weight were measured in minimum clothing without shoes based on the standard method. Later, the nutrient intake data were collected using the 2-day food intake record at the beginning and end of the chemotherapy. Nutrition IV Software was applied to evaluate the received nutrients.
Results: In this research, the mean body mass index of patients was lower at the end than the beginning of chemotherapy (P = 0.001). Mean of serum albumin and total protein were normal at the beginning of the study, which was significantly reduced at the end of study (P = 0.01 and 0.01). Mean of energy, macronutrients, and micronutrients intake indicated a significant reduction from the beginning to the end of treatment (P < 0.05).
Conclusion: Findings of this study showed that the mean of serum albumin, total protein and energy, macronutrients, and micronutrients intake indicated a significant reduction from the beginning to the end of treatment in this research.
SOCIO-ECONOMIC, TRADING SOPHISTICATION AND SELF-REFLECTION ON INVESTORS’ HERDING BIAS: EVIDENCE FROM COLOMBO STOCK EXCHANGE
Authors: Kawshala B.A.H , Anuradha P. A. N. S , Shamil Mohamed M. 
Published: January 2021

Purpose of the study: Individual investor’s behavior is extensively influenced by biases that are highlighted in the growing discipline of behavioral finance. The present study sought to investigate the influence of socio-economic factors (i.e., investors’ age, gender, education, profession, and income), trading sophistication factors (i.e., trading experience and trading frequency), and self-reflection on herding bias in investment decision-making in Colombo Stock Exchange (CSE). Methodology: The study adopted descriptive and explanatory research designs. It was a census of all 243 individual investors registered with CSE as of September 2020. Sampling was done applying proportionate stratified random sampling technique and data was gathered using self-administered semi-structured questionnaires. The analysis was conducted using means, standard deviations, and regression. Main Findings: The results show that herd behavior is mostly seen among females, having less educational qualifications, who are engaged in the finance field professions, those who are with a very low monthly income, low experience, and who trade less frequently. Self-reflection can be seen in herding bias. On the other hand, age does not impact on herding bias of investors. Applications of this study: This study will be helpful to financial intermediaries to advise their clients. Moreover, the results of the present study facilitate individual investors to realize their herding bias by its’ determinants in the pursuit of making sensible and effective financial decisions. Novelty/Originality of this study: This study gives a unique insight into the investors’ profile corresponding to herding bias under consideration. It not only updates the evidence on herding bias but also highlights which factors are the most influential on herding bias in the Sri Lankan context. With the peculiar scenario in Sri Lanka, this paper contributed to the behavioral finance field as a reference for individual investors and financial advisors.
COST LEADERSHIP STRATEGY, COMPETITIVE ADVANTAGE, AND PERFORMANCE: A CROSS-SECTIONAL STUDY IN THE CONTEXT OF MILK PROCESSING FIRMS IN KENYA
Authors: G. Kimiti Paul , M. A. Muathe Stephen , M. Murigi Elishiba 
Published: January 2021

Purpose of the study: Cost leadership strategy is driven by economies of scale, economies of scope, and operational efficiency is a remedy to a performance where firms are facing high costs. This study sought to investigate the influence of cost leadership strategy on the performance of milk processing firms in Kenya through the lens of competitive advantage as a mediator.
Methodology: The study adopted descriptive and explanatory non-experimental research designs. It was a census of all 29 milk processing firms registered with Kenya Dairy Board as of June 2019. Sampling was done using proportionate stratified random sampling technique and data was collected using self-administered semi-structured questionnaires. The analysis was done using means, standard deviations, and regression.
Main Findings: The findings showed that a cost leadership strategy had a positive and significant effect on the performance of milk processing firms in Kenya with a competitive advantage partially mediating the relationship. The constituent measures of cost leadership strategy namely economies of scale, economies of scope, and operational efficiency accounted for 40.1% of the variation in firm performance.
Applications of this study: This study provides suggestions for firms to manage costs and therefore improve performance. This is by increasing the size of operations, expanding into related business areas, and improving operational processes.
Novelty/originality of this study: The study examines the influence of cost leadership strategy in a new context of milk processing firms in Kenya. It also incorporates a competitive advantage as a significant variable affecting the relationship between costs and performance.
THE CHANGES IN FOOD CONSUMPTION BEHAVIOR: A RAPID OBSERVATIONAL STUDY OF COVID-19 PANDEMIC
Authors: Sandi Wachyuni Suci , Wiweka Kadek 
Published: January 2021

Purpose of the Study: This study aims to identify food consumption behaviour at pre, during, and post-pandemic (possibility). Methodology: This study uses a quantitative-based descriptive study approach to explain changes in consumer consumption patterns. Sampling was done by using probability sampling techniques or by a simple random sampling method. Electronic-questionnaire distribution was carried out through the WhatsApp broadcast message application to which 75 respondents responded. Meanwhile, a simple quantitative analysis method is used to calculate several formulas, including mean value, frequency distribution, and percentage. Main Findings: The results showed that health, social, and psychological factors influenced the respondent's food consumption behaviour. There are increasing organic food intentions and self-cooking trends. Besides, this study also shows an increasing awareness of the importance of aspects of health, quality, and food safety in choosing food. Implication/Applications: This research can be used as a theoretical reference, especially related to the factors that influence eating behaviour during a pandemic. Also, the results of this research can be used by culinary businesses to design strategies to survive the Covid-19 pandemic by adjusting products, innovating, and improving product quality based on consumer needs. The originality of the study: The paper is original, and this is the current study to examine the food consumption behavior of local communities in the pandemic issue.
LUXURY REDEFINED: A CASE STUDY OF THE ANANDA-IN THE HIMALAYAS, UTTARAKHAND, INDIA
Authors: Mehta Rahul 
Published: January 2021

Purpose of study: The purpose of this case study is to comprehend how the allure of a hotel plays a significant role in a tourist’s goal of decision, desires for the fulfilment, aims to return to, an impression of advantages and inspirations, the measure of cash spent, and the duration of the stay.
Methodology: This study employed a descriptive case study of the Ananda-In the Himalayas, focusing on understanding the various design perspectives of this place with the different amenities provided by it, making it one of the top luxury destination resort.
Main Findings: According to this study, the destination, amenities provided, and hospitality of this place make it the top wellness resort. The place is a beautiful combination of design architecture, elegant lighting and has a connection with nature, which makes it attractive for its visitors.
Limitations: The study has only been done of one restaurant with a proper literature review. Therefore, the results of the study may be applied with caution outside the scope of the study.
Social Implications: Although this case study is way more descriptive than predictive, the results can help researchers from varied realms of hospitality and tourism with valuable insights regarding the direction of future publishing efforts in this field. This study may also help researchers to understand the design concepts and features required for a luxury destination spa resort.
Originality: This place has not been studied with a perspective of this kind, and therefore, not much literature is there, especially on this resort. However, this study will bridge the gap between the design features, destination, and the hospitality provided by the resort. This study can be used as a benchmark for other studies, which will be done based on both tourism and hospitality, and in today’s era, both are becoming more demanding, more varied, and more qualitative.
RESOURCE PROTECTION STRATEGIES TOWARDS SUSTAINABLE ECOTOURISM AND PROTECTED AREA CONSERVATION: A VISITORS’ EVALUATION IN BULUSAN VOLCANO NATURAL PARK, PHILIPPINES
Authors: Rebuya Niño 
Published: January 2021

Purpose of the study: This study has evaluated the resource protection strategies in Bulusan Volcano Natural Park (BVNP) along with environmental/biophysical conservation, cultural preservation, social conservation, and physical/behavioral conservation in ensuring sustainable ecotourism operation and protected area conservation.
Methodology: It employed a quantitative method of research directed towards presenting, analyzing, and interpreting the data. The selection of respondents was done through the Convenience Sampling Technique where every possible respondent has the same chance of being selected during the administration of the survey questionnaire. Data were analyzed using weighted mean and standard deviation in determining the homogeneity/heterogeneity of the visitors’ evaluation.
Main Findings: The strategies on social and environmental conservation are effective and more given emphasis on BVNP. Likewise, with physical or behavioral conservation strategies which also recognized effective mechanisms in managing visitors’ use. However, the cultural preservations were evaluated very low as most of the visitors disagreed that the strategies for this aspect are manifested in the actions of the host community.
Applications of this study: Findings of this paper is deemed relevant and useful for natural park administrators and ecotourism destination operators as it provides new insights on the effectiveness of resource protection strategies and suggests future policy actions to ensure sustainability.
Novelty/Originality Of this study: This study is novel in evaluating the resource protection strategies in protected areas (BVNP) and in determining how conservation approaches enhance the visitor experience in natural parks.
ECOTOURISM DEVELOPMENT AS A TOOL FOR SUSTAINABLE ENVIRONMENTAL CONSERVATION AND ITS IMPLICATION TO COMMUNITY LIVELIHOOD: THE CASE OF THE SHEKA BIOSPHERE RESERVE, SOUTH WEST ETHIOPIA
Authors: Assefa Biniam , Meseret Ferede 
Published: January 2021

Purpose of the study: The majority of Ethiopian are engaged in agricultural activities that contributed to natural resource degradations. Ecotourism is an alternative option while achieving the conservation goals of protected areas. This study was conducted with the objective of identifying ecotourism development opportunities as a tool for future environmental conservation and its implication to community livelihoods in Sheka Biosphere Reserve.
Methodology: using survey questionnaires, document analysis, and field observation. To that end, information was collected and analyzed from 120 household heads living around the Biosphere reserve using a structured questionnaire. In addition, focus group discussions and key informant interviews were used. Field observations were held for recording ecotourism potentials using digital camera and GPS. The data collected by the above methods were analyzed using SPSS version 21.
Main Findings: The findings revealed that Sheka Biosphere reserve is endowed with attractive landscape scenery, fauna and flora and indigenous culture of the local community, which are the existing potentials for ecotourism development in the area, whereas, the current status of ecotourism development is at the lower stage as compared to its potentials. Soil fertility reduction, market problems, and the absence of ecotourism activities were the major socio-economic problems of the local community.
Social Implications/Applications: Ecotourism development as a tool for sustainable environmental conservation and its implication can be useful for community livelihood.
Novelty/Originality of this study: This study has shown that introducing ecotourism and development of infrastructures are central strategic directions for sustainable management of the Biosphere Reserve.
Pengaruh Minimisasi Energi MMFF94 dengan MarvinSketch dan Open Babel PyRx pada Penambatan Molekular Turunan Oksindola Tersubstitusi
Authors: Hanif Atika Umi , Lukis Prima Agusti , Fadlan Arif 
Published: January 2021

In silico technique is widely used for drug discovery because it can predict the conformation of ligands in protein macromolecules and it can calculate the binding affinity. The energy minimization is carried out to make the ligand more stable near the initial state during molecular docking process. The Merck Molecular Force Field (MMFF94) is one type of energy minimization process often used in organic compounds. The molecular docking of substituted oxindole derivatives on indoleamine macromolecules 2,3-dioxygenase (IDO-1, PDB: 2D0T) by MMFF94 minimization operated by MarvinSketch and Open Babel in PyRx showed different results. The binding affinity energy obtained was also quite different, but the ligands have the same conformation and bind the same residue with slightly different bond distances. Keywords: Molecular docking, energy minimization, substituted oxindole, Merck Molecular Force Field 94 Teknik in silico banyak digunakan untuk penemuan senyawa obat karena dapat memprediksi konformasi suatu ligan dalam makromolekul protein dan mampu menghitung nilai afinitas ikatan. Proses minimisasi energi dilakukan untuk menjadikan ligan lebih stabil mendekati keadaan awal selama penambatan molekular berlangsung. Merck Molecular Force Field (MMFF94) adalah salah satu jenis persamaan minimisasi energi yang sering digunakan pada senyawa organik. Hasil pengujian pengaruh minimisasi energi dengan MMFF94 menggunakan program MarvinSketch dan Open Babel dalam PyRx pada turunan oksindola tersubstitusi alkil terhadap makromolekul 2,3-dioxygenase indoleamine (IDO-1, PDB: 2D0T) menunjukkan hasil dengan nilai yang berbeda. Energi afinitas ikatan yang didapatkan juga cukup berbeda, namun ligan memiliki konformasi yang sama dan mengikat residu yang sama dengan jarak ikatan yang sedikit berbeda. Kata kunci: Penambatan molekular, minimisasi energi, oksindola tersubstitusi, Merck Molecular Force Field 94