bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Hyperparathyroidism Masquerading as Acute
Pancreatitis
Authors: Arora Saurabh , Singh Parminder , Verma Rohit , Mittal Naveen , Sood Ajit , Kalra Sanjay , Shanthaiah Dhananjaya 
Published: June 2021

AbstractAcute pancreatitis as an initial manifestation of primary hyperparathyroidism
(PHPT) is a rare occurrence and timely diagnosis of PHPT is crucial in
preventing repeat attack of pancreatitis. The study aimed at evaluating the
clinico-radiological profile of patients admitted with acute pancreatitis as the
index presentation of PHPT and to determine the factors associated with
development of severe pancreatitis. This series included retrospective analysis
of medical records of 30 patients admitted with acute pancreatitis as initial
manifestation of PHPT. Additionally, we analyzed the data of another 30 patients
admitted with PHPT but without any evidence of pancreatitis, to serve as control
group. The mean age of the subjects was 44.9±13.9 years with male to
female ratio of 1.30. The mean serum calcium level was 12.24±2.79
mg/dl and five (16.6%) patients had normocalcemia at time of
presentation. Presence of nephrolithiasis was significantly associated with
severe pancreatitis. One patient had refractory hypercalcemia associated with
renal failure and was successfully managed with denosumab. Patients with PHPT
associated with acute pancreatitis had significantly higher calcium levels and
lower frequency of skeletal involvement as compared to PHPT patients without
pancreatitis. PHPT masquerading as acute pancreatitis is rare and high index of
suspicion is required to diagnose this condition especially in the presence of
normocalcemia at presentation. Patients with PHPT associated pancreatitis had
male preponderance, higher calcium levels, and lower frequency of skeletal
involvement as compared to PHPT patients without pancreatitis.
Recognition of intersensory relationships based on duration in infants four, seven and 10 months old (Reconocimiento de relaciones intersensoriales basadas en la duración en bebés de cuatro, siete y 10 meses)
Authors: Martínez Mauricio , Español Silvia , Igoa José-Manuel 
Published: June 2021

Since birth, infants develop the ability to perceive a wide range of intersensory relations among various kinds of amodal temporal information. This study addresses the development of the ability to perceive duration-based intersensory relations. Three groups of infants, four, seven and 10 months old, participated in two trials of an intersensory 5preference task that used two audiovisual stimuli showing a woman executing two performances — with characteristics similar to the way adults interact with infants — consisting of sequences of sound-movement/silence-stillness of varying durations. The results show that infants at all three ages recognize the duration-based intersensory relation; however, recognition is expressed in different ways at each age according to the trial and the number of eye fixations recorded. These results are discussed in terms of the development of the ability to recognize duration-based intersensory relations and its relationship to between-subjects development.
Measurement of the bulk radioactive contamination of detector-grade silicon with DAMIC at SNOLAB
Authors: Aguilar-Arevalo A. , Amidei D. , Baxter D. , Cancelo G. , Cervantes Vergara B.A. , Chavarria A.E. , Darragh-Ford E. , D'Olivo J.C. , Estrada J. , Favela-Perez F. , Gaïor R. , Guardincerri Y. , Hossbach T.W. , Kilminster B. , Lawson I. , Lee S.J. , Letessier-Selvon A. , Matalon A. , Mitra P. , Piers A. , Privitera P. , Ramanathan K. , Da Rocha J. , Sarkis Y. , Settimo M. , Smida R. , Thomas R. , Tiffenberg J. , Traina M. , Vilar R. , Virto A.L. 
Published: June 2021

Abstract
We present measurements of bulk radiocontaminants in the high-resistivity silicon CCDs from the DAMIC experiment at SNOLAB. We utilize the exquisite spatial resolution of CCDs to discriminate between α and β decays, and to search with high efficiency for the spatially-correlated decays of various radioisotope sequences. Using spatially-correlated β decays, we measure a bulk radioactive contamination of 32Si in the CCDs of 140 ± 30 μBq/kg, and place an upper limit on bulk 210Pb of < 160 μBq/kg. Using similar analyses of spatially-correlated α and β decays, we set upper limits of < 11 μBq/kg (0.9 ppt) on 238U and < 7.3 μBq/kg (1.8 ppt) on 232Th in the bulk silicon. The ability of DAMIC CCDs to identify and reject spatially-coincident backgrounds, particularly from 32Si, has significant implications for the next generation of silicon-based dark matter experiments, where β's from 32Si decay will likely be a dominant background.
Emergence of oscillons in kink-impurity interactions
Authors: Lizunova Mariya , Kager Jasper , de Lange Stan , van Wezel Jasper 
Published: June 2021

Abstract
The (1 + 1)-dimensional classical φ
4 theory contains stable, topological excitations in the form of solitary waves or kinks, as well as a non-topological one, such as the oscillon. Both are used in effective descriptions of excitations throughout myriad fields of physics. The oscillon is well-known to be a coherent, particle-like structure when introduced as an ansatz in the φ
4 theory. Here, we show that oscillons also arise naturally in the dynamics of the theory, in particular as the result of kink–antikink collisions in the presence of an impurity. We show that in addition to the scattering of kinks and the formation of a breather, both bound oscillon pairs and propagating oscillons may emerge from the collision. We discuss their resonances and critical velocity as a function of impurity strength and highlight the role played by the impurity in the scattering process.
Reproductive Performance of Java Barb (Punctius javanicus) Injected sGNRH and Domperidone of Different Dosage
Authors: Yuniarti T , Basuki F , Hastuti S , Nugroho R A , Marantika S 
Published: June 2021

Abstract
Java barb (P. javanicus) is freshwater fish frequently found in Java and Sumatra waters of Indonesia. Java Barb has a seasonal spawning cycle. Accordingly, the production of java barb seeds is limited by season. Therefore, it is necessary to research on hormonal manipulating systems of reproduction to needs of seeds. This study aimed to determine the effect of sGnRH and domperindone on Java barb reproductive performance. There were 12 female and 12 male java barb broodstock, with 400-500 grams and 300-400 grams bodyweight respectively. The broodstock used on third stage of gonadal maturation. This study used an experimental method with a completely randomized design (CRD) consisting of 4 treatments and 3 replicates. Mixture of GnRH and domperidone was injected intramuscularly. The dosage treatments used were dosage A (control), treatment B (0.3 ml/kg), treatment C (0.4 ml/kg) and treatment D (0.5 ml/kg). The data gathered included latency period, fertilization rate (FR), hatching rate (HR), survival rate (SR) and water quality. The results showed that the injection of sGnRH and domperidone produced different latency periods, significantly affected (P <0.05) fertilization rate (FR) and hatching rate (HR), but had no significant effect on survival (SR). The best results were obtained at treatment. B and treatment C with 0.3 ml/kg and 0,4 ml/kg dosage resulting in 9-12 hours latency period, 80,50±5,57 to 84.33 ± 5.51% of Fertilization Rate (FR), 68,83±6,81 to 71.17 ± 5.35% Hatching Rate (HR) and 53,85±2,35 to 60.69 ± 10.66% of Survival Rate (SR).
The Integration of Regional Spatial Planning (RTRW) and Coastal Spatial Planning (RZWP3K) for The Sustainable Coastal Area Development
Authors: Darmawan M , Sutrisno D , Dewi C , Setiyawan I E 
Published: June 2021

Abstract
The disharmony between land and marine spatial planning is threatening the planning of sustainable coastal development. In Indonesia, land spatial planning has firstly been implemented, followed by the spatial zonation of coastal waters. Therefore, to achieve sustainable coastal zone management, the harmonization between the regional spatial plan or RTRW with the zoning plan for coastal waters and small islands or RZWP3K is urgently needed. This paper aims to examine the spatial problems in the process of integrating these two spatial plans. Using the spatial review method, the stages of study consist of forming the seamless spatial planning maps of 8 provincial regions in Indonesia that have stipulated the second regional regulation on spatial planning regimes and then integrated them with the coastal waters spatial planning zonation map (rzwp3k). The findings show the potential conflict in some areas, especially in protected areas with cultivation and public use, and between the cultivation areas, fisheries, and industries. Other findings are on the technical aspect, which shows the differences in the coastal area due to the use of two different coastlines and base maps. Regarding substance, there are differences in the content of the framework of the RTRW and RZWP3K mandates in regional regulation.
Fuel cell electric vehicles: A review of current power electronic converters Topologies and technical challenges
Authors: Baba Mariem Ahmed , Labbadi Moussa , Cherkaoui Mohamed , Maaroufi Mohammed 
Published: June 2021

Abstract
This paper proposes a brief review to study the implementation of fuel cells and management energy in hybrid vehicles. The use of fuel cells (FC) in the automotive field has been growing steadily over the last decades thanks to their simple operation, quiet running, and high efficiency. In addition, fuel cell vehicles have great advantages over electrified vehicles powered by secondary batteries in terms of mileage endurance, energy efficiency, charging speed and climate tolerance. In this paper, the classification and a brief introduction of HEVs/FCs are reviewed, then topologies of fuel cell HEVs are presented that illustrate the hybrid vehicle system of the different FC architectures. Finally, a discussion of control strategies for hydrogen fuel cell vehicles is implemented with the clarification of future prospects for HEVs.
ECCO Topical Review: Refractory Inflammatory Bowel Disease
Authors: Raine Tim , Verstockt Bram , Kopylov Uri , Karmiris Konstantinos , Goldberg Rimma , Atreya Raja , Burisch Johan , Burke John , Ellul Pierre , Hedin Charlotte , Holubar Stefan D , Katsanos Konstantinos , Lobaton Triana , Schmidt Carsten , Cullen Garret 
Published: June 2021

Abstract
Inflammatory bowel disease is a chronic disease with variable degrees of extent, severity, and activity. A proportion of patients will have disease that is refractory to licensed therapies, resulting in significant impairment in quality of life. The treatment of these patients involves a systematic approach by the entire multidisciplinary team, with particular consideration given to medical options including unlicensed therapies, surgical interventions, and dietetic and psychological support. The purpose of this review is to guide clinicians through this process and provide an accurate summary of the available evidence for different strategies.
Inoculative Releases and Natural Spread of the Fungal PathogenEntomophaga maimaiga(Entomophthorales: Entomophthoraceae) into U.S. Populations of Gypsy Moth,Lymantria dispar(Lepidoptera: Erebidae)
Authors: Hajek Ann E , Diss-Torrance Andrea L , Siegert Nathan W , Liebhold Andrew M 
Published: June 2021

AbstractWhile emphasis with entomopathogens has often been on inundative releases, we describe here historic widespread inoculative releases of a fungal entomopathogen. Several U.S. states and municipalities conducted inoculative releases of the gypsy moth, Lymantria dispar (L.) (Lepidoptera: Erebidae), pathogen Entomophaga maimaiga Humber, Shimazu et Soper (Entomophthorales: Entomophthoraceae) after 1993, as gypsy moth populations spread into the Midwest and North Carolina. This Japanese pathogen first caused epizootics in northeastern North America in 1989 and methods for its inoculative release were tested and proven to be effective from 1991 to 1993. After 1993, spores in soil or in late instar cadavers were collected during or after epizootics and were released inoculatively into newly established populations of this spreading invasive; the goal was that spores would overwinter and germinate the next spring to infect larvae, thus speeding pathogen spread and hastening the development of epizootics in newly established populations. The fungus was released in gypsy moth populations that were separated from areas where the fungus was already established. In particular, extensive releases by natural resource managers in Wisconsin and Michigan aided the spread of E. maimaiga throughout these states. Where it has become established, this acute pathogen has become the dominant natural enemy and has exerted considerable influence in reducing gypsy moth damage. While this pathogen most likely would have invaded these new regions eventually, releases accelerated the spread of E. maimaiga and helped to reduce impacts of initial outbreaks, while further outbreaks were reduced by the pathogen’s subsequent persistence and activity in those areas.
How Can We Fully Realize the Potential of Mathematical and Biological Models to Reintegrate Biology?
Authors: Dornhaus Anna , Smith Brian , Hristova Kalina , Buckley Lauren B 
Published: June 2021

SynopsisBoth mathematical models and biological model systems stand as tractable representations of complex biological systems or behaviors. They facilitate research and provide insights, and they can describe general rules. Models that represent biological processes or formalize general hypotheses are essential to any broad understanding. Mathematical or biological models necessarily omit details of the natural systems and thus may ultimately be “incorrect” representations. A key challenge is that tractability requires relatively simple models but simplification can result in models that are incorrect in their qualitative, broad implications if the abstracted details matter. Our paper discusses this tension, and how we can improve our inferences from models. We advocate for further efforts dedicated to model development, improvement, and acceptance by the scientific community, all of which may necessitate a more explicit discussion of the purpose and power of models. We argue that models should play a central role in reintegrating biology as a way to test our integrated understanding of how molecules, cells, organs, organisms, populations, and ecosystems function.
Compositional Similarities that Link the Eyes and Skin of Cephalopods: Implications in Optical Sensing and Signaling during Camouflage
Authors: Deravi Leila F 
Published: June 2021

Synopsis
Cephalopods, including squid, octopus, and cuttlefish, can rapidly camouflage in different underwater environments by employing multiple optical effects including light scattering, absorption, reflection, and refraction. They can do so with exquisite control and within a fraction of a second—two features that indicate distributed, intra-dermal sensory, and signaling components. However, the fundamental biochemical, electrical, and mechanical controls that regulate color and color change, from discrete elements to interconnected modules, are still not fully understood despite decades of research in this space. This perspective highlights key advancements in the biochemical analysis of cephalopod skin and discusses compositional connections between cephalopod ocular lenses and skin with features that may also facilitate signal transduction during camouflage.
Continuity of Monge–Ampère Potentials in Big Cohomology Classes
Authors: Dang Quang-Tuan 
Published: June 2021

AbstractExtending Di Nezza–Lu’s approach [16] to the setting of big cohomology classes, we prove that solutions of degenerate complex Monge–Ampère equations on compact Kähler manifolds are continuous on a Zariski open set. This allows us to show that singular Kähler–Einstein metrics on log canonical varieties of general type have continuous potentials on the ample locus outside of the non-klt part.
In situ observation of the deterioration process of sulfide-based solid electrolytes using airtight and air-flow TEM systems
Authors: Tsukasaki Hirofumi , Igarashi Keisuke , Wakui Akiko , Yaguchi Toshie , Nakajima Hiroshi , Kimura Takuya , Sakuda Atsushi , Tatsumisago Masahiro , Hayashi Akitoshi , Mori Shigeo 
Published: June 2021

Abstract
Sulfide-based solid electrolytes (SEs) exhibiting high ionic conductivity are indispensable battery materials for next-generation all-solid-state batteries. However, sulfide-based SEs have a major drawback in their low chemical stability in air. When exposed to H2O or O2 gas, toxic H2S is generated, and their ionic conductivity considerably declines. However, their degradation mechanism caused by air exposure has not been understood yet. To clarify the degradation process, in this study, we developed a transmission electron microscope (TEM) system to evaluate the air stability of battery materials. Using a vacuum transfer double-tilt TEM holder with a gas-flow system, the in situ observation of the degradation process was conducted for a sulfide-based Li4SnS4 glass ceramic under an air-flow environment. Consequently, electron diffraction (ED) patterns and TEM images could clearly capture morphological changes and the amorphization process caused by air exposure. Moreover, based on the analysis of ED patterns, it is observed that Li4SnS4 is likely to decompose because of the reaction with H2O in air. Therefore, this airtight and air-flow TEM system should be effective in clarifying the process of the deterioration of sulfur-based SEs during exposure to air.
Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome
Authors: Nissen Mette , Ikäheimo Tiina-Mari , Huttunen Jukka , Leinonen Ville , Jyrkkänen Henna-Kaisa , von und zu Fraunberg Mikael 
Published: June 2021

Abstract

BACKGROUND
Spinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). The effect of neuropathic pain medication use on SCS outcome is poorly understood.

OBJECTIVE
To study the effect of gabapentinoid use on SCS outcome measured by trial success, explantation rate and opioid dose reduction during a 2-yr follow-up.

METHODS
The study cohort included 203 consecutive FBSS patients who underwent SCS in a single tertiary center during January 1997 to March 2014. Purchase data of gabapentinoids, opioids, tricyclic antidepressants, serotonin and noradrenaline reuptake inhibitors, and benzodiazepines during January 1995 to March 2016 were retrieved from national registries.

RESULTS
In multivariate Cox regression analysis, patients using gabapentinoids had significantly fewer explantations during the 2-yr follow-up (hazard ratio [HR] 0.2, 95% CI 0.04-0.81, P = .03). In contrast, patients with opioid use of >40 morphine milligram equivalent before implantation had significantly more explantations (HR 6.7, 95% CI 2.5-18, P < .01). In bivariate logistic regression analysis adjusted for patient specific factors, year of SCS implantation, use of neuropathic pain medication, opioids, and benzodiazepines, patients using gabapentinoids significantly more often discontinued opioids or reduced their dose by more than 50% during the 2-yr follow-up (odds ratio 5.7, 95% CI 1.4-23, P = .015).

CONCLUSION
The use of gabapentinoids was associated with a significantly lower spinal cord stimulator explantation rate and a higher chance of opioid discontinuation or >50% dose reduction. This indicates that patients with SCS could benefit from concomitant use of gabapentinoids. Prospective randomized trials are warranted to verify this hypothesis.
Modulation of Nicotinic Receptors by Cannabinoids
Authors: Rodriguez‐Tirado Carla Sofia , Colon‐Saez Jose Orlando , Lasalde‐Dominicci Jose 
Published: June 2021

The legalization of medicinal and recreational use of marijuana by many states in the USA, has resulted in an increase in its use. The two most abundant phytocannabinoids in marijuana Δ9‐Tetrahydrocannabinol (THC) and cannabidiol (CBD) have been shown to have tremendous therapeutic potential in many neurological disorders such as anxiety, seizures, post‐traumatic stress disorder and pain. One study showed that CBD use reduces cigarette consumption by 40%. However, little is known about the effects that these phytocannabinoids have on the function of nicotinic acetylcholine receptors (nAChRs). Published results showed that CBD reduces the response of the α7 nAChR to acetylcholine (ACh). Through this project we are characterizing the effects of CBD and THC on the function of the α7 nAChR. Our results indicate that CBD reduces the response of the α7 nAChR to ACh by 49% (p value=0.0003); and that CBD alone does not activate the receptor. Interestingly, THC seems to have the opposite effect, it appears to increase the response of the α7 nicotinic receptor to ACh by a 128% (pvalue=0.44). When both drugs were combined at a 1:1 ratio, the observed effect was an inhibition. The effect was intermediate to the effect seem with either drug alone, the observed response was 62% of the normal response (pvalue=0.007). The response of the α7 nicotinic receptor to CBD and THC seems to be independent of the concentration of ACh applied. Which suggests that neither CBD nor THC compete with ACh for the binding site. Dissecting the effects of phytocannabinoids found in marijuana on the nervous system is critical to increase our chances of using it successfully in the clinic.Support or Funding InformationNIH‐Maximizing Access to Research Careers (Grant # 5T34GM007821‐38)This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.