bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cross-sectional Study on Perceived Workplace Health Support and Health-Related Quality of Life
Authors: Kurogi Kazushirou , Ikegami Kazunori , Eguchi Hisashi , Tsuji Mayumi , Tateishi Seiichiro , Nagata Tomohisa , Matsuda Shinya , Fujino Yoshihisa , Ogami Akira ,   the CORoNaWork Project
Published: September 2021

AbstractObjectiveMany companies in Japan have been increasingly interested in “health and productivity management (H&PM).” In terms of H&PM, we supposed that companies can enhance their employees’ perceived workplace health support (PWHS) by providing support for workers’ lively working and healthy living. This could then improve health-related QOL (HRQOL) by increasing PWHS. This study explored the relationship between PWHS and health-related quality of life (HRQOL).MethodsDuring the COVID-19 pandemic in December 2020, we conducted an Internet-based nationwide health survey of Japanese workers (CORoNaWork study). A database of 27,036 participants was created. The question regarding the intensity of PWHS was measured using a four-point Likert scale. We used a linear mixed model (LMM) to analyze the relationship between the intensity of PWHS and the four domains of CDC HRQOL-4 (self-rated health, number of poor physical health days, number of poor mental-health days, and activity limitation days during the past 30 days).ResultsIn the sex- and age-adjusted and multivariate models, the intensity of PWHS had a main effect on self-rated health and the three domains of unhealthy days (physical, mental, activity limitation). There was also a trend toward worse HRQOL scores as the PWHS decreased.ConclusionsThis study aimed to document the relationship between PWHS and HRQOL. We found that the higher the PWHS of Japanese workers, the higher their self-rated health and the lower their unhealthy days. Companies need to assess workers’ PWHS and HRQOL and promote H&PM. H&PM is also necessary to maintain and promote the health of workers during the COVID-19 pandemic.
A Delay Differential Equation approach to model the COVID-19 pandemic
Authors: Kiselev I.N. , Akberdin I.R. , Kolpakov F.A. 
Published: September 2021

AbstractSEIR (Susceptible - Exposed - Infected - Recovered) approach is a classic modeling method that has frequently been applied to the study of infectious disease epidemiology. However, in the vast majority of SEIR models and models derived from them transitions from one population group to another are described using the mass-action law which assumes population homogeneity. That causes some methodological limitations or even drawbacks, particularly inability to reproduce observable dynamics of key characteristics of infection such as, for example, the incubation period and progression of the disease’s symptoms which require considering different time scales as well as probabilities of different disease trajectories. In this paper, we propose an alternative approach to simulate the epidemic dynamics that is based on a system of differential equations with time delays to precisely reproduce a duration of infectious processes (e.g. incubation period of the virus) and competing processes like transition from infected state to the hospitalization or recovery. The suggested modeling approach is fundamental and can be applied to the study of many infectious disease epidemiology. However, due to the urgency of the COVID-19 pandemic we have developed and calibrated the delay-based model of the epidemic in Germany and France using the BioUML platform. Additionally, the stringency index was used as a generalized characteristic of the non-pharmaceutical government interventions implemented in corresponding countries to contain the virus spread. The numerical analysis of the calibrated model demonstrates that adequate simulation of each new wave of the SARS-CoV-2 virus spread requires dynamic changes in the parameter values during the epidemic like reduction of the population adherence to non-pharmaceutical interventions or enhancement of the infectivity parameter caused by an emergence of novel virus strains with higher contagiousness than original one. Both models may be accessed and simulated at https://gitlab.sirius-web.org/covid-19/dde-epidemiology-model utilizing visual representation as well as Jupyter Notebook.
Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
Authors: Ghraichy Marie , von Niederhäusern Valentin , Kovaltsuk Aleksandr , Galson Jacob D. , Deane Charlotte M. , Trück Johannes 
Published: September 2021

AbstractBackgroundSeveral human B-cell subpopulations are recognized in the peripheral blood, which play distinct roles in the humoral immune response. These cells undergo developmental and maturational changes involving VDJ recombination, somatic hypermutation and class switch recombination, altogether shaping their immunoglobulin heavy chain (IgH) repertoire.MethodsHere, we sequenced the IgH repertoire of naïve, marginal zone, switched and plasma cells from 10 healthy adults along with matched unsorted and in silico separated CD19+ bulk B cells. We used advanced bioinformatic analysis and machine learning to thoroughly examine and compare these repertoires.ResultsWe show that sorted B cell subpopulations are characterised by distinct repertoire characteristics on both the individual sequence and the repertoire level. Sorted subpopulations shared similar repertoire characteristics with their corresponding in silico separated subsets. Furthermore, certain IgH repertoire characteristics correlated with the position of the constant region on the IgH locus.ConclusionOverall, this study provides unprecedented insight over mechanisms of B cell repertoire control in peripherally circulating B cell subpopulations.
A third dose of inactivated vaccine augments the potency, breadth, and duration of anamnestic responses against SARS-CoV-2
Authors: Wang Kang , Cao Yunlong , Zhou Yunjiao , Wu Jiajing , Jia Zijing , Hu Yaling , Yisimayi Ayijiang , Fu Wangjun , Wang Lei , Liu Pan , Fan Kaiyue , Chen Ruihong , Wang Lin , Li Jing , Wang Yao , Ge Xiaoqin , Zhang Qianqian , Wu Jianbo , Wang Nan , Wu Wei , Gao Yidan , Miao Jingyun , Jiang Yinan , Qin Lili , Zhu Ling , Huang Weijin , Zhang Yanjun , Zhang Huan , Li Baisheng , Gao Qiang , Xie Xiaoliang Sunney , Wang Youchun , Wang Qiao , Wang Xiangxi 
Published: September 2021

AbstractEmergence of variants of concern (VOC) with altered antigenic structures and waning humoral immunity to SARS-CoV-2 are harbingers of a long pandemic. Administration of a third dose of an inactivated virus vaccine can boost the immune response. Here, we have dissected the immunogenic profiles of antibodies from 3-dose vaccinees, 2-dose vaccinees and convalescents. Better neutralization breadth to VOCs, expeditious recall and long-lasting humoral response bolster 3-dose vaccinees in warding off COVID-19. Analysis of 171 complex structures of SARS-CoV-2 neutralizing antibodies identified structure-activity correlates, revealing ultrapotent, VOCs-resistant and broad-spectrum antigenic patches. Construction of immunogenic and mutational heat maps revealed a direct relationship between “hot” immunogenic sites and areas with high mutation frequencies. Ongoing antibody somatic mutation, memory B cell clonal turnover and antibody composition changes in B cell repertoire driven by prolonged and repeated antigen stimulation confer development of monoclonal antibodies with enhanced neutralizing potency and breadth. Our findings rationalize the use of 3-dose immunization regimens for inactivated vaccines.One sentence summaryA third booster dose of inactivated vaccine produces a highly sifted humoral immune response via a sustained evolution of antibodies capable of effectively neutralizing SARS-CoV-2 variants of concern.
Evaluation of Primary Prescription Nonadherence Post-discharge from an Inpatient Psychiatry Unit at a Large Urban Community Hospital – an Observational Study
Authors: Ganjam Meghana , Ruiz Ysatis , Allen Luis G. , Persaud Rosemary 
Published: September 2021

AbstractIntroductionHere, we aimed to evaluate primary prescription nonadherence post-discharge from an acute inpatient psychiatric unit. Prescription nonadherence is a concern across all patient care settings, with primary nonadherence defined as not picking up prescribed medication from the pharmacy or not delivering prescriptions to the pharmacy. Secondary nonadherence, defined as filling a prescription but not taking the medication as prescribed, was not tracked in this study. The incidence of nonadherence can vary widely across settings and has been reported to range from 3– 86%. This is a particular concern in patients with a primary psychiatric diagnosis both in an outpatient and inpatient setting.DesignThe prescription fill rate of eligible patients was tracked on days 7 and 21 post-discharge from acute inpatient psychiatric units of an acute care multispecialty urban community teaching hospital.ResultsIn total, 72 patients aged 18 and above (44%, women) were analyzed. A primary nonadherence incidence of 43% was found, which did not vary significantly across the analyzed variables of age, sex, or primary diagnosis.ConclusionPrimary nonadherence is a significant issue in this population. Strategies, such as the implementation of “med-to-bed” programs and use of longer acting injectables when appropriate, would help in increasing adherence. Further research, including the evaluation of other variables that affect nonadherence, is needed to identify and develop steps to overcome the obstacles to adherence.
Large-scale proteome and metabolome analysis of CSF implicates altered glucose metabolism and succinylcarnitine in Alzheimer’s disease
Authors: Panyard Daniel J. , McKetney Justin , Deming Yuetiva K. , Morrow Autumn R. , Ennis Gilda E. , Jonaitis Erin M. , Van Hulle Carol A. , Yang Chengran , Sung Yun Ju , Ali Muhammad , Kollmorgen Gwendlyn , Suridjan Ivonne , Bayfield Anna , Bendlin Barbara B. , Zetterberg Henrik , Blennow Kaj , Cruchaga Carlos , Carlsson Cynthia M. , Johnson Sterling C. , Asthana Sanjay , Coon Joshua J. , Engelman Corinne D. 
Published: September 2021

AbstractA major hallmark of Alzheimer’s disease (AD) is the aggregation of proteins (β-amyloid (A) and hyperphosphorylated tau (T)) in the brain, which makes the AD proteome in cerebrospinal fluid (CSF) of particular interest. Here, we conducted a CSF proteome-wide analysis among participants with and without AD pathology (n = 137 total participants: 56 A-T-, 39 A+T-, and 42 A+T+; 915 proteins analyzed), using a panel of 9 CSF biomarkers for neurodegeneration and neuroinflammation. We identified 61 proteins significantly associated with AT category (P < 5.46 x 10-5; strongest was SMOC1, P = 1.87 x 10-12) and 636 significant protein-biomarker associations (P < 6.07 x 10-6; strongest was a positive association between neurogranin and EPHA4, P = 2.42 x 10-25). Community network and pathway enrichment analyses highlighted three biomarker-associated protein networks centered around amyloid and tau measures, neurogranin, and the remaining biomarkers. Glucose metabolic pathways were enriched primarily among the amyloid- and tau-associated proteins, including malate dehydrogenase and aldolase A, both of which were associated with CSF phosphorylated tau levels in an independent replication cohort of 717 participants (P = 8.65 x 10-56and P = 1.35 x 10-45). Follow-up interrogation of related CSF metabolite levels in the same samples as the discovery proteomics analysis identified increasing levels of succinylcarnitine with ptau and numerous other CSF biomarkers (P < 0.00056) that were replicated in an independent sample of 363 participants. Together, these results implicate glucose metabolic dysregulation and increased CSF succinylcarnitine levels as amyloid and tau pathology emerge in AD.One Sentence Summary:Combining cerebrospinal fluid proteomics data with neurodegeneration and neuroinflammation biomarkers, genomics, and cerebrospinal fluid metabolomics, we identify and replicate a theme of altered glucose metabolism proteins and the metabolite succinylcarnitine across amyloid and tau progression in Alzheimer’s disease.
Immunogenicity and Safety of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with malignancy
Authors: Ariamanesh Mona , Porouhan Pejman , PeyroShabany Babak , Fazilat-Panah Danial , Dehghani Mansoureh , Nabavifard Maryam , Hatami Farbod , Fereidouni Mohammad , Welsh James S. , Javadinia Seyed Alireza 
Published: September 2021

AbstractObjectivePatients with malignancy suffer from a compromised immune system due to either the effects of malignancies or treatments. Cancer patients are at higher risk of different infections particularly SARS-CoV2 and usually produce weaker response to vaccines. The aim of this study was to evaluate the safety and immunogenicity of the inactivated SARS-CoV-2 vaccine (Sinopharm, BBIBP-CorV) in patients with malignancy.Material and MethodIn total 364 patients with cancer (median age: 54 years old, F/M ratio: 217/147) who received two doses of Sinopharm vaccine were enrolled in this study. Vaccine related side effects was assessed by a questionnaire and the presence of SARS-CoV-2 anti-Spike protein (S) IgG and neutralizing antibody two months following vaccination were measured by immunological methods.ResultsInjection site pain and fever were the most common local and systemic side effects in vaccine receivers. Two months after the first dose, anti-S IgG and neutralizing antibody were detectable in 77.1% and 80.7% of all participants, respectively with an overall response to either or both measured in 86.9% of patients The rate of seroconversion was lower in older age, those with hematological malignancies and chemotherapy receivers.ConclusionThe result of study confirmed the safety and short-term efficacy of Sinopharm inactivated vaccine (BBIBP-CorV) in patients with different type of malignancies.
MITIGATING THE 4th WAVE OF THE COVID-19 PANDEMIC IN ONTARIO
Authors: Cipriano Lauren E. , Haddara Wael M. R. , Sander Beate 
Published: September 2021

ABSTRACTBackgroundThe goal of this study was to project the number of COVID-19 cases and demand for acute hospital resources for Fall of 2021 in a representative mid-sized community in southwestern Ontario. We sought to evaluate whether current levels of vaccine coverage and contact reduction could mitigate a potential 4th wave fueled by the Delta variant, or whether the reinstitution of more intense public health measures will be required.MethodsWe developed an age-stratified dynamic transmission model of COVID-19 in a mid-sized city (population 500,000) currently experiencing a relatively low, but increasing, infection rate in Step 3 of Ontario’s Wave 3 recovery. We parameterized the model using the medical literature, grey literature, and government reports. We estimated the current level of contact reduction by model calibration to cases and hospitalizations. We projected the number of infections, number of hospitalizations, and the time to re-instate high intensity public health measures over the fall of 2021 under different levels of vaccine coverage and contact reduction.ResultsMaintaining contact reductions at the current level, estimated to be a 17% reduction compared to pre-pandemic contact levels, results in COVID-related admissions exceeding 20% of pre-pandemic critical care capacity by late October, leading to cancellation of elective surgeries and other non-COVID health services. At high levels of vaccination and relatively high levels of mask wearing, a moderate additional effort to reduce contacts (30% reduction compared to pre-pandemic contact levels), is necessary to avoid re-instating intensive public health measures. Compared to prior waves, the age distribution of both cases and hospitalizations shifts younger and the estimated number of pediatric critical care hospitalizations may substantially exceed 20% of capacity.DiscussionHigh rates of vaccination coverage in people over the age of 12 and mask wearing in public settings will not be sufficient to prevent an overwhelming resurgence of COVID-19 in the Fall of 2021. Our analysis indicates that immediate moderate public health measures can prevent the necessity for more intense and disruptive measures later.
Common and Disorders-Specific Cortical Thickness Alterations in Internalizing, Externalizing and Thought Disorders over a 2-year Period in the Preadolescents of the ABCD Study
Authors: Yu Gechang , Wu Xinran , Liu Zhaowen , Becker Benjamin , Zhang Kai , Kuang Nanyu , Kang Jujiao , Dong Guiying , Zhao Xing-Ming , Schumann Gunter , Feng Jianfeng , Sahakian Barbara J. , Robbins Trevor W. , Palaniyappan Lena , Zhang Jie 
Published: September 2021

AbstractOverlap of brain changes across mental disorders has reinforced transdiagnostic models. However, the developmental basis for this overlap is unclear as are neural differences among internalizing, externalizing and thought disorders. These issues are critical to inform the theoretical framework for hierarchical transdiagnostic psychiatric taxonomy. We examined cortical thickness (CT) difference between healthy controls (n=4041) and patients with externalizing (n=1182), internalizing (n=1959) and thought (n=347) disorders in preadolescents (9-10 years) from the Adolescent Brain and Cognitive Development Study using linear mixed models. Genome-wide association analysis and cell type specificity analysis were performed on regional CT across 4,716 unrelated European youth. We found that youth with externalizing or internalizing disorders, but not thought disorders, exhibited significantly thicker cortex than controls. Externalizing and internalizing disorders shared thicker CT in left pars opercularis and caudal middle frontal gyrus related to lower cognitive performance. Somatosensory and primary auditory cortex were uniquely affected in externalizing disorders; primary motor cortex and higher-order visual association areas were uniquely affected in internalizing disorders. Only group of externalizing disorders demonstrated significant CT increase than controls at 2-year follow-up and decelerated cortical thinning from 10 to 12 years old. At genetic level, genes associated with CT in common and disorders-specific regions were also implicated in related diagnostic families. Microglia were the cell-type associated with CT for both externalizing/internalizing while dopaminergic/glutamatergic/GABAergic cells related only to externalizing-specific regions. These results showed that distinct anatomical trajectories relevant to internalizing/externalizing phenotypes may result from unique genetic and cell-type changes, but these occur in the background of significantly shared morphological variance.
Personal protective equipment does not sufficiently protect against virus aerosol unless combined with advanced air purification or ventilation techniques
Authors: Landry Shane A , Subedi Dinesh , Barr Jeremy J , MacDonald Martin I , Dix Samantha , Kutey Donna M , Mansfield Darren , Hamilton Garun S , Edwards Bradley A. , Joosten Simon A 
Published: September 2021

ABSTRACTBackgroundHealthcare workers (HCWs) are at risk from nosocomial transmission of SARS-CoV-2 from virus laden aerosols. This study aimed to: 1) quantify the degree of protection from virus aerosol provided by different types of mask (surgical, N95, fit-tested N95) and personal protective equipment (PPE); 2) determine if the use of a portable HEPA filter can enhance the effectiveness of PPE; 3) determine the effectiveness of a decontamination shower to remove virus aerosol contamination of a HCW.MethodsVirus aerosol exposure experiments were conducted using bacteriophage PhiX174 (108copies/mL). A HCW wearing PPE (mask, gloves, gown, faceshield) was exposed to nebulised viruses for 40mins in a sealed clinical room. After exiting, the HCW doffed PPE. Virus exposure was quantified via skin swabs applied to the face and nostrils, forearms, neck, and forehead. Experiments were performed with and without the presence of a portable HEPA filter (set to 470m3/hr).FindingsSwabs quantified significant virus exposure under the surgical and N95 mask. Only the fit-tested N95 resulted in lower virus counts compared to no mask control (p=0.027). Nasal swabs demonstrated very high virus exposure, which was not mitigated by the surgical or N95 masks, although there was a trend for the fit-tested N95 mask to reduce virus counts (p=0.058). The addition of HEPA filtration substantially reduced virus counts from all swab sites, and to near zero levels when combined with a fit-tested N95 mask, gloves, gown and faces shield. Virus counts were substantially reduced to near zero levels following a shower.InterpretationThese data demonstrate that quantitatively fit tested N95 masks combined with a HEPA filter can offer protection against high virus aerosol loads at close range and for prolonged periods of time. Skin contamination from virus aerosol can be effectively by removed by showering.FundingEpworth Hospital Capacity Building Research Grant ID: EH2020-654
Effectiveness of inactive COVID-19 vaccines against severe illness in B.1.617.2 (Delta) variant-infected patients in Jiangsu, China
Authors: Hu Zhiliang , Tao Bilin , Li Zhongqi , Song Yan , Yi Changhua , Li Junwei , Zhu Meng , Yi Yongxiang , Huang Peng , Wang Jianming 
Published: September 2021

AbstractThe SARS-CoV-2 B.1.617.2 (Delta) variant has caused a new surge in the number of COVID-19 cases. The effectiveness of vaccines against this variant is not fully understood. Using data from a recent large-scale outbreak of COVID-19 in China, we conducted a real-world study to explore the effect of inactivated vaccine immunization on the course of disease in patients infected with Delta variants. We recruited 476 confirmed cases over the age of 18, of which 42 were severe. After adjusting for age, gender, and comorbidities, patients who received two doses of inactivated vaccine (fully vaccinated) had an 88% reduced risk in progressing to the severe stage (adjusted OR: 0.12, 95% CI: 0.02- 0.45). However, this protective effect was not observed in patients who only received only one dose of the vaccine(adjusted OR: 1.11, 95% CI: 0.51- 2.36). The full immunization offered 100% protection from a severe illness among women. The effect of the vaccine was potentially affected by underlying medical conditions (OR: 0.26, 95% CI: 0.03-1.23). This is the largest real-world study confirming the effectiveness of inactive COVID-19 vaccines against severe illness in Delta variant-infected patients in Jiangsu, China.