bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Formulation of Angiotensin-(1-7) Promotes Therapeutic Actions in a Model of Eosinophilic and Neutrophilic Asthma
Authors: Magalhães Giselle Santos , Gregório Juliana Fabiana , Cançado Ribeiro Arthur Tonani Pereira , Baroni Isis Felippe , Vasconcellos Ana Victoria de Oliveira , Nakashima Gabriela Pansanato , Oliveira Isabel Fusaro Aguiar , Matos Natália Alves de , Castro Thalles de Freitas , Bezerra Frank Silva , Sinisterra Ruben D. , Pinho Vanessa , Teixeira Mauro Martins , Santos Robson Augusto Souza , Rodrigues-Machado Maria Glória , Campagnole-Santos Maria José 
Published: March 2021

The presence of eosinophils and neutrophils in the lungs of asthmatic patients is associated with the severity of the disease and resistance to corticosteroids. Thus, defective resolution of eosinophilic and neutrophilic inflammation is importantly related to exacerbation of asthma. In this study, we investigated a therapeutic action of angiotensin-(1-7) (Ang-(1-7)) in a model of asthma induced by ovalbumin (OVA) and lipopolysaccharide (LPS). Balb-c mice were sensitized and challenged with OVA. Twenty-three hours after the last OVA challenge, experimental groups received LPS, and 1 h and 7 h later, mice were treated with oral formulation of Ang-(1-7). On the next day, 45 h after the last challenge with OVA, mice were subjected to a test of motor and exploratory behavior; 3 h later, lung function was evaluated, and bronchoalveolar lavage fluid (BALF) and lungs were collected. Motor and exploratory activities were lower in OVA + LPS-challenged mice. Treatment with Ang-(1-7) improved these behaviors, normalized lung function, and reduced eosinophil, neutrophil, myeloperoxidase (MPO), eosinophilic peroxidase (EPO), and ERK1/2 phosphorylation (p-ERK1/2) in the lungs. In addition, Ang-(1-7) decreased the deposition of mucus and extracellular matrix in the airways. These results extended those of previous studies by demonstrating that oral administration of Ang-(1-7) at the peak of pulmonary inflammation can be valuable for the treatment of neutrophil- and eosinophil-mediated asthma. Therefore, these findings potentially provide a new drug to reverse the natural history of the disease, unlike the current standards of care that manage the disease symptoms at best.
Meta-Analysis of ABCG2 and ABCB1 Polymorphisms With Sunitinib-Induced Toxicity and Efficacy in Renal Cell Carcinoma
Authors: Sun Fengjun , Chen Zhuo , Yao Pu , Weng Bangbi , Liu Zhirui , Cheng Lin 
Published: March 2021

Background: ABCG2 and ABCB1 are genes related to the pharmacokinetics of sunitinib and have been associated with its toxicity and efficacy. However, the results have been controversial. This study aimed to evaluate the associations of ABCG2 and ABCB1 polymorphisms with sunitinib-induced toxicity and efficacy in renal cell carcinoma (RCC) by meta-analysis.Methods:PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies investigating the associations of the ABCG2 rs2231142 polymorphism with sunitinib-induced toxicity and the associations of the ABCB1 rs1128503 and ABCB1 rs2032582 polymorphisms with sunitinib-induced toxicity and clinical outcomes. The associations were evaluated by effect size (ES) with 95% confidence intervals (CIs).Results: Eight and five studies were included in the toxicity and efficacy analysis, respectively, including a total of 1081 RCC patients. The ABCG2 rs2231142 A allele was associated with an increased risk of sunitinib-induced thrombocytopenia and hand-foot syndrome (HFS) in Asians (ES = 1.65, 95% CI = 1.15–2.36, p = 0.006; ES = 1.52, 95% CI = 1.02–2.27, p = 0.041). However, the ABCG2 rs2231142 polymorphism was not associated with sunitinib-induced hypertension or neutropenia (ES = 1.09, 95% CI = 0.69–1.73, p = 0.701; ES = 0.87, 95% CI = 0.57–1.31, p = 0.501). Compared with the C allele, the ABCB1 rs1128503 T allele was associated with a decreased risk of sunitinib-induced hypertension but worse progression-free survival (PFS) (ES = 0.44, 95% CI = 0.26–0.77, p = 0.004; ES = 1.36, 95% CI = 1.07–1.73, p = 0.011). There was no significant association between the T allele or C allele of ABCB1 rs1128503 and overall survival (OS) (ES = 0.82, 95% CI = 0.61–1.10, p = 0.184). The ABCB1 rs2032582 T allele was associated with worse PFS than the other alleles (ES = 1.46, 95% CI = 1.14–1.87, p = 0.003), while there was no significant association between the T allele or other alleles and sunitinib-induced hypertension, HFS, or OS (ES = 0.77, 95% CI = 0.46–1.29, p = 0.326; ES = 1.02, 95% CI = 0.65–1.62, p = 0.919; ES = 1.32, 95% CI = 0.85–2.05, p = 0.215).Conclusion: The results indicate that the ABCG2 rs2231142 polymorphism may serve as a predictor of sunitinib-induced thrombocytopenia and HFS in Asians, while the ABCB1 rs1128503 polymorphism may serve as a predictor of sunitinib-induced hypertension, and both the ABCB1 rs1128503 and rs2032582 polymorphisms may serve as predictors of PFS in RCC. These results suggest a possible application of individualized use of sunitinib according to the genetic background of patients.
The Ameliorating Effects of Bushen Huatan Granules and Kunling Wan on Polycystic Ovary Syndrome Induced by Dehydroepiandrosterone in Rats
Authors: Xu Yang , Pan Chun-Shui , Li Quan , Zhang Hao-Lin , Yan Li , Anwaier Gulinigaer , Wang Xiao-Yi , Yan Lu-Lu , Fan Jing-Yu , Li Dong , Han Jing-Yan 
Published: March 2021

AimTo investigate the effects of Bushen Huatan Granules (BHG) and Kunling Wan (KW), the two Chinese medicines, on the regulation of polycystic ovary syndrome (PCOS) and their underlying mechanisms.Materials and MethodsPCOS rat model was established by subcutaneous injection of dehydroepiandrosterone (DHEA) (6 mg/100 g/day) for 20 days, followed by treatment with BHG (0.75, 1.49, and 2.99 g/kg) or KW (0.46, 0.91, and 1.82 g/kg) by gavage for 4 weeks. Estrous cycle was detected by vaginal smears. Follicles development was assessed by histology. Levels of testosterone and insulin in serum were tested by ELISA. Apoptosis of Granulosa cells (GCs) was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling staining. Pathways associated with apoptosis were detected with western blot. Pregnancy outcome was also assessed. GCs were pre-treated with 10–5 M testosterone in vitro for 24 h, then incubated with serum from rats receiving BHG (1.49 g/kg) or KW (1.82 g/kg). The parameters concerning apoptosis, mitochondrial function and endoplasmic reticulum stress were assessed.ResultsPost-treatment with either BHG or KW ameliorated DHEA-induced irregular estrous cycles, follicles development abnormalities, increase of testosterone and insulin in serum, and the apoptosis of GCs. Post-treatment with BHG decreased the expression of cleaved caspase-9/caspase 9, release of cytochrome C from mitochondria, and mitochondria reactive oxygen species production, increased activities of complex I, II, IV of ovarian tissue. Post-treatment with KW decreased the levels of caspase-12, GRP78, C/EBP homologous protein, phosphorylation of IRE-I, x-box-binding protein 1s, as well as phosphorylation of proline-rich receptor-like protein kinase, phosphorylation of eukaryotic translation initiation factor 2α and ATF4 of ovarian tissue and GCs. Both BHG and KW ameliorated pregnancy outcome.ConclusionThis study demonstrated BHG or KW as a potential strategy for treatment of PCOS induced by DHEA, and suggested that the beneficial role of the two medicines were mediated by different pathway with the effect of BHG being correlated with the regulation of mitochondria, while the effect of KW being attributable to protection of endoplasmic reticulum stress.
Barriers and Facilitators for Mental Health Service Use Among Racial/Ethnic Minority Adolescents: A Systematic Review of Literature
Authors: Lu Wenhua , Todhunter-Reid Abigail , Mitsdarffer Mary Louise , Muñoz-Laboy Miguel , Yoon Anderson Sungmin , Xu Lei 
Published: March 2021

Introduction: Mental disorders represent serious public health concerns in the U.S. Compared with Whites, racial/ethnic minority adolescents are more likely to be affected by mental disorders but less likely to use mental health services. This systematic review aimed to summarize factors related to mental health service use among minority adolescents in the U.S. as identified in previous research.Methodology: Following the PRISMA guideline, we systematically searched seven databases for peer reviewed articles related to barriers and facilitators of mental health service use among racial/ethnic minority adolescents.Results: Thirty-two quantitative studies met our inclusion criteria, among which 12 studies (37.5%) sampled mostly Blacks or African Americans, 6 studies (18.7%) focused primarily on Hispanics or Latin/a/x, including Mexican Americans and Puerto Ricans, and 4 studies (12.5%) were mostly Asian Americans (e.g., Chinese, Vietnamese). Based on the socio-ecological framework, 21 studies (65.6%) identified adolescent-related barriers and facilitators of mental health service use, including biological (e.g., age, gender), clinical (e.g., symptom severity), behavioral (e.g., drug/alcohol use), and psychological characteristics (e.g., internal asset) of minority youth. Ten studies (31.3%) identified parents-related factors that influenced minority adolescent mental health service use, including parental perceptions and beliefs, family and parenting issues, and demographic characteristics. Primary factors at the therapist level included ethnic match between patient and practitioner, relationship with healthcare practitioners, and patient-therapist co-endorsement of etiological beliefs. Fifteen studies (46.9%) identified factors influencing minority adolescent mental health service use at the contextual/structural level, including household income, insurance status, and family structure. Lastly, acculturation and school experiences were major factors at the social/cultural level that influence minority adolescent service use.Conclusion: More empirical studies are needed to understand the mechanism underlying minority adolescents' unmet mental health service needs. Culturally competent interventions are warranted to engage minority adolescents with mental disorders into treatment.
Extension of remote distance of electromagnetically spinning viscometer
Authors: Hosoda M. , Yamakawa Y. , Sakai K. 
Published: March 2021

Abstract
An electromagnetically spinning (EMS) viscometer enables the remote sensing of rheological properties. To date, the distance of remote sensing of EMS system has been limited by the aperture size of rotating magnets, which drive the rotation of the metal viscosity probe through electromagnetic interactions. In this study, we develop a new device that can extend the remote distance. The extender is composed of a pair of freely rotating magnets set in a confined sample container, which rotates synchronously to the main driving magnets and applies torque to the probe above the extender. The remote distance is successfully extended up to 100 mm. We carried out the viscosity measurement for lowly viscous samples and examined that the EMS system equipped with a remote distance extender works as a viscometer with a measurement accuracy of 1%.
PERBANDINGAN TUGAS MEDIATOR PADA PENGADILAN AGAMA INDONESIA DENGAN MAHKAMAH SYARIAH MALAYSIA
Authors: Hanifah Mardalena 
Published: March 2021

Article 3 (2) Regulation of the Supreme Court of the Republic of Indonesia Number 1 of 2016 concerning Mediation Procedures, Case Examining Judges in the consideration of a decision must state that the case has been pursued peace through mediation by mentioning the mediator. The court is not only tasked with examining, trying, and resolving cases it receives but also seeks to reconcile the parties. The court, which has been impressed as a law enforcement and justice institution, now appears as an institution that seeks peaceful solutions for the parties. The implementation of Regulation of the Supreme Court of the Republic of Indonesia Number 1 of 2016 concerning Mediation Procedures in Courts can be an eff ort to resolve civil disputes so that the settlement of civil disputes through mediation is the main choice. The research method used is normative legal research which includes research on legal principles which is very basic in guided law. The nature of the research carried out is descriptive, namely research that describes and explains in clear and detailed sentences. The data used are secondary data obtained from literature, consisting of primary, secondary, and tertiary legal materials. Processing and data analysis used qualitative methods. The defi nition of mediation according to the Religious Courts in Indonesia and the Syari’ah Courts in Malaysia is the eff ort of the judges and courts to reconcile the parties so that the divorce process does not continue at the next trial. When the mediation process was carried out at the Indonesian Religious Court and the Syari’ah Court in Malaysia, there was a similarity, namely the mediation process was carried out at the fi rst trial and it was an obligation for the disputing parties in a divorce case to take mediation. according to the procedure for the appointment of mediators at the Indonesian Religious Courts and the Syari’ah Courts in Malaysia and the appointments of these mediators are both made by the judges.
Premenstrüel Sendrom Semptomlarının Evlilik Uyumu İle İlişkisi
Authors: BAŞAĞAÇ Elif , EGE Emel 
Published: March 2021

Amaç: Premenstrüel sendrom kadının, günlük aktivitelerini, iş performansını, aile ve sosyal ilişkileri ile yaşam kalitesini olumsuz etkileyebilir. Bu çalışma, evli kadınlarda premenstrüel sendrom semptomlarının evlilik uyumu ile ilişkisini değerlendirmek amacıyla yapılmıştır.
Yöntem: Tanımlayıcı ve ilişki arayıcı tipte planlanan araştırmanın örneklemini 18-49 yaş grubu evli 138 kadın oluşturmuştur. Verilerin toplanmasında demografik soru formu, Premenstrüel Değerlendirme Formu (PDF), Evlilikte Uyum Ölçeği (EUÖ) kullanılmıştır.
Bulgular: Araştırmada kadınların Evlilik Uyum Ölçeği toplam puan ortalaması 40.33±12.88, Premenstrüel Değerlendirme Formu toplam puan ortalaması 216.18±75.83 olarak tespit edilmiştir. Kadınların Evlilik Uyum Ölçeği puanları ile Premenstrüel Değerlendirme Formu toplam puanları arasında orta düzeyde, negatif yönde ve anlamlı düzeyde bir ilişki olduğu saptanmıştır (p
The Similarity of Abundance Ratio Trends and Nucleosynthetic Patterns in the Milky Way Disk and Bulge
Authors: Griffith Emily , Weinberg David H. , Johnson Jennifer A. , Beaton Rachael , García-Hernández D. A. , Hasselquist Sten , Holtzman Jon , Johnson James W. , Jönsson Henrik , Lane Richard R. , Nataf David M. , Roman-Lopes Alexandre 
Published: March 2021

Abstract
We compare abundance ratio trends in a sample of ∼11,000 Milky Way bulge stars (R
GC < 3 kpc) from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) to those of APOGEE stars in the Galactic disk (5 kpc < R
GC < 11 kpc). We divide each sample into low-Ia (high-[Mg/Fe]) and high-Ia (low-[Mg/Fe]) populations, and in each population, we examine the median trends of [X/Mg] versus [Mg/H] for elements X = Fe, O, Na, Al, Si, P, S, K, Ca, V, Cr, Mn, Co, Ni, Cu, and Ce. To remove small systematic trends of APOGEE abundances with stellar

, we resample the disk stars to match the

distributions of the bulge data. After doing so, we find nearly identical median trends for low-Ia disk and bulge stars for all elements. High-Ia trends are similar for most elements, with noticeable (0.05–0.1 dex) differences for Mn, Na, and Co. The close agreement of abundance trends (with typical differences ≲0.03 dex) implies that similar nucleosynthetic processes enriched bulge and disk stars despite the different star formation histories and physical conditions of these regions. For example, we infer that differences in the high-mass slope of the stellar initial mass function between disk and bulge must have been ≲0.30. This agreement, and the generally small scatter about the median sequences, means that one can predict all of a bulge star's APOGEE abundances with good accuracy knowing only its measured [Mg/Fe] and [Mg/H] and the observed trends of disk stars.
Shocks and Molecules in Diffuse Interstellar Cloud Pairs
Authors: Reach William T. , Heiles Carl 
Published: March 2021

Abstract
The diffuse interstellar medium (ISM) is dynamic, and its chemistry and evolution are determined by shock fronts as well as photodissociation. Shocks are implied by the supersonic motions and velocity dispersion, often statistically called “turbulence”. We compare models of magnetohydrodynamic (MHD) shocks, with speeds typical of cloud motions through the ISM (3–25 km s−1) and densities typical of cold neutral gas (∼102 cm−3), to archival observations of the H i 21 cm line for gas kinematics, far-infrared emission for dust mass, and mid-infrared emission for high-resolution morphology, to identify shock fronts in three high-latitude cloud pairs with masses of order 50 M
⊙. The clouds have “heads” with extended “tails,” and high-resolution images show arcs on the leading edges of the “heads” that could be individual shocks. The H i shows higher-velocity gas at the leading edges due to shock-accelerated material. For two cloud pairs, one cloud has an active shock indicated by broad and offset H i, while the other cloud has already been shocked and is predominantly “CO-dark” H2. Two-dimensional MHD simulations for shocks parallel to the magnetic field for pairs of clouds show a remarkable similarity to observed cloud features, including merged “tails” due to aligned flow and magnetic field, which leads to lateral confinement downstream. A parallel alignment between magnetic field and gas flow may lead to formation of small molecular clouds.
Finite System-size Effects in Self-organized Criticality Systems
Authors: Aschwanden Markus J. 
Published: March 2021

Abstract
We explore upper limits for the largest avalanches or catastrophes in nonlinear energy dissipation systems governed by self-organized criticality. We generalize the idealized “straight” power-law size distribution and Pareto distribution functions in order to accommodate incomplete sampling, limited instrumental sensitivity, finite system-size effects, and “Black Swan” and “Dragon King” extreme events. Our findings are as follows. (i) Solar flares show no finite system-size limits up to L ≲ 200 Mm, but solar flare durations reveal an upper flare duration limit of ≲6 hr. (ii) Stellar flares observed with Kepler exhibit inertial ranges of E ≈ 1034–1037 erg, finite system-size ranges of E ≈ 1037–1038 erg, and extreme events at E ≈ (1–5) × 1038 erg. (iii) The maximum flare energies of different spectral type stars (M, K, G, F, A, giants) reveal a positive correlation with the stellar radius, which indicates a finite system-size limit imposed by the stellar surface area. Fitting our finite system-size models to terrestrial data sets (earthquakes, wildfires, city sizes, blackouts, terrorism, words, surnames, web links) yields evidence (in half of the cases) for finite system-size limits and extreme events, which can be modeled with dual power-law size distributions.
State-switching Mechanism of Intermittent Pulsars
Authors: Rusul Abdujappar , Zheng Xiao-Ping , Esamdin Ali , Guo Liang , Xia Li-Xin 
Published: March 2021

Abstract
The emission feature of intermittent pulsars is significant for understanding the pulsar emission mechanism. Using the observational evidence of radio emissions turning on and off and the corresponding spin-down rates in these two states of an intermittent pulsar, we will examine the polar-cap potential drop, gap height, and curvature radii of a few intermittent pulsars within the regime of the pulsar polar-cap emission theory by applying the current loss and energy flux of particle flow to pulsar braking, which are generally associated with radio emission from the polar cap. It is seen that the polar-cap parameters of the intermittent pulsars are almost equal to their maximum values, which is the main prediction of the pulsar polar-cap theory with respect to the breaking of the radio emission. It is also noticed that the intermittent pulsars are distributed near the dipole death line in the

diagram, which is consistent with their emission features and the calculated polar-cap parameters. To further confirm the state switching of the intermittent pulsar, the relationships among spin-down rate, gap height, potential drop, and activity duty cycles of PSR B1931+24 are discussed. It is found that the gap height has an anticorrelation with the activity duty cycle, which indicates that the intermittency of the radio emission has a close connection to the gap height, as indicated by the pulsar polar-cap emission theory.
Detection of Tidal Disruption Events around Direct-collapse Black Holes at High Redshifts with the James Webb Space Telescope
Authors: Regős Enikő , Vinkó József , Stermeczky Zsófia V. 
Published: March 2021

Abstract
This is the third sequel in a series discussing the discovery of various types of extragalactic transients with the James Webb Space Telescope (JWST) in a narrow-field (∼0.1 deg2), moderately deep (m
AB ∼ 27 mag) survey. In this part we focus on the detectability and observational characteristics of direct-collapse black holes (DCBHs) and tidal disruption events (TDEs) around them. We use existing models for DCBH accretion luminosities and spectra, as well as for TDE light curves, and find that accreting DCBH seeds may be bright enough for detection up to z ∼ 7 with JWST NIRCam imaging. TDEs of massive (M ≳ 50 M
⊙) stars around them can enhance the chance for discovering them as transient objects, although the rate of such events is low, a few per survey time. TDEs around nonaccreting black holes of M ∼ 106
M
⊙ may also be detected at z < 7 redshifts in the redder NIRCam bands between 3 and 5 μs. It is also shown that accreting DCBHs appear separate from supernovae on the NIRCam color–color plot, but TDEs from quiescent black holes fall in nearly the same color range as superluminous supernovae, which makes them more difficult to identify.
The Discovery of a Highly Accreting, Radio-loud Quasar at z = 6.82
Authors: Bañados Eduardo , Mazzucchelli Chiara , Momjian Emmanuel , Eilers Anna-Christina , Wang Feige , Schindler Jan-Torge , Connor Thomas , Andika Irham Taufik , Barth Aaron J. , Carilli Chris , Davies Frederick B. , Decarli Roberto , Fan Xiaohui , Farina Emanuele Paolo , Hennawi Joseph F. , Pensabene Antonio , Stern Daniel , Venemans Bram P. , Wenzl Lukas , Yang Jinyi 
Published: March 2021

Abstract
Radio sources at the highest redshifts can provide unique information on the first massive galaxies and black holes, the densest primordial environments, and the epoch of reionization. The number of astronomical objects identified at z > 6 has increased dramatically over the last few years, but previously only three radio-loud (R
2500 = f

ν,5 GHz/f

ν,2500 Å > 10) sources had been reported at z > 6, with the most distant being a quasar at z = 6.18. Here we present the discovery and characterization of PSO J172.3556+18.7734, a radio-loud quasar at z = 6.823. This source has an Mg ii-based black hole mass of ∼3 × 108
M
⊙ and is one of the fastest accreting quasars, consistent with super-Eddington accretion. The ionized region around the quasar is among the largest measured at these redshifts, implying an active phase longer than the average lifetime of the z ≳ 6 quasar population. From archival data, there is evidence that its 1.4 GHz emission has decreased by a factor of two over the last two decades. The quasar’s radio spectrum between 1.4 and 3.0 GHz is steep (α = −1.31). Assuming the measured radio slope and extrapolating to rest-frame 5 GHz, the quasar has a radio-loudness parameter R
2500 ∼ 90. A second steep radio source (α = −0.83) of comparable brightness to the quasar is only 23.″1 away (∼120 kpc at z = 6.82; projection probability <2%), but shows no optical or near-infrared counterpart. Further follow-up is required to establish whether these two sources are physically associated.