bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparative accuracy and safety of fluoroscopic and navigation-based techniques in cervical pedicle screw fixation: systematic review and meta-analysis
Authors: Tarawneh Ahmad M. , Haleem Shahnawaz , D’Aquino Daniel , Quraishi Nasir 
Published: June 2021

OBJECTIVE
The goal of this study was to evaluate the comparative accuracy and safety of navigation-based approaches for cervical pedicle screw (CPS) placement over fluoroscopic techniques.

METHODS
A systematic search of the literature published between January 2006 and December 2019 relating to CPS instrumentation and the comparative accuracy and safety of fluoroscopic and intraoperative computer-based navigation techniques was conducted. Several databases, including the Cochrane Library, PubMed, and EMBASE, were systematically searched to identify potentially eligible studies. Data relating to CPS insertion accuracy and associated complications, in particular neurovascular complications, were extrapolated from the included studies and summarized for analysis.

RESULTS
A total of 17 studies were identified from the search methodology. Eleven studies evaluated CPS placement under traditional fluoroscopic guidance and 6 studies addressed outcomes following navigation-assisted placement (3D C-arm or CT-guided placement). Overall, a total of 4278 screws were placed in 1065 patients. Misplacement rates of CPS were significantly lower (p < 0.0001) in navigation-assisted techniques (12.51% [range 2.5%–20.5%]) compared to fluoroscopy-guided techniques (18.8% [range 0%–43.5%]). Fluoroscopy-guided CPS insertion was associated with a significantly higher incidence of postoperative complications relating to neurovascular injuries (p < 0.038), with a mean incidence of 1.9% compared with 0.3% in navigation-assisted techniques.

CONCLUSIONS
This systematic review supports a logical conclusion that navigation-based techniques confer a statistically significantly more accurate screw placement and resultant lower complication rates.
Risk of secondary neoplasms after external-beam radiation therapy treatment of pediatric low-grade gliomas: a SEER analysis, 1973–2015
Authors: Rodrigues Adrian J. , Jin Michael C. , Wu Adela , Bhambhvani Hriday P. , Li Gordon , Grant Gerald A. 
Published: June 2021

OBJECTIVE
Although past studies have associated external-beam radiation therapy (EBRT) with higher incidences of secondary neoplasms (SNs), its effect on SN development from pediatric low-grade gliomas (LGGs), defined as WHO grade I and II gliomas of astrocytic or oligodendrocytic origin, is not well understood. Utilizing a national cancer registry, the authors sought to characterize the risk of SN development after EBRT treatment of pediatric LGG.

METHODS
A total of 1245 pediatric patient (aged 0–17 years) records from 1973 to 2015 were assembled from the Surveillance, Epidemiology, and End Results (SEER) database. Univariable and multivariable subdistribution hazard regression models were used to evaluate the prognostic impact of demographic, tumor, and treatment-related covariates. Propensity score matching was used to balance baseline characteristics. Cumulative incidence analyses measured the time to, and rate of, SN development, stratified by receipt of EBRT and controlled for competing mortality risk. The Fine and Gray semiparametric model was used to estimate future SN risk in EBRT- and non–EBRT-treated pediatric patients.

RESULTS
In this study, 366 patients received EBRT and 879 did not. Forty-six patients developed SNs after an LGG diagnosis, and 27 of these patients received EBRT (OR 3.61, 95% CI 1.90–6.95; p < 0.001). For patients alive 30 years from the initial LGG diagnosis, the absolute risk of SN development in the EBRT-treated cohort was 12.61% (95% CI 8.31–13.00) compared with 4.99% (95% CI 4.38–12.23) in the non–EBRT-treated cohort (p = 0.013). Cumulative incidence curves that were adjusted for competing events still demonstrated higher rates of SN development in the EBRT-treated patients with LGGs. After matching across available covariates and again adjusting for the competing risk of mortality, a clear association between EBRT and SN development remained (subhazard ratio 2.26, 95% CI 1.21–4.20; p = 0.010).

CONCLUSIONS
Radiation therapy was associated with an increased risk of future SNs for pediatric patients surviving LGGs. These data suggest that the long-term implications of EBRT should be considered when making treatment decisions for this patient population
Sleep of the Soul and Resurrection of the Body: Aphrahat’s Anthropology in Context
Authors: Walters J. Edward 
Published: June 2021

Abstract
The fourth-century Syriac corpus known as the Demonstrations, attributed to Aphrahat, the Persian Sage, provides a unique window into the early development of Christianity among Syriac-speaking communities. Occasionally these writings attest to beliefs and practices that were not common among other contemporaneous Christian communities, such as Aphrahat’s apparent belief in the “sleep of the soul” and the implications of that belief for his concept of the soul-body relationship and what happens to the soul and body at the resurrection. Aphrahat addresses this topic in the context of a polemical argument against an unnamed opponent, which provides the occasion to consider whom these arguments might be addressed against. The present article seeks to understand Aphrahat’s views on the body and soul within the broad religious milieu of the eastern Mediterranean world in Late Antiquity. The article concludes with an argument for reading and understanding the Demonstrations as a witness to the contested development of Christian identity in the Syriac-speaking world.
Encuadres de la violencia machista: estudio comparativo de las noticias sobre delitos con victimas (1996-2016)
Authors: Gorosarri González Maria 
Published: June 2021

Este artículo analiza el tratamiento de los delitos con víctimas en los dos periódicos de referencia en España, El País y El Mundo. Siguiendo la teoría del enfoque (‘framing’), mediante el análisis de contenido, se medirán cuatro encuadres habituales que inciden en la consideración social de la violencia machista: identificación más detallada de la denunciante que del agresor, construcción de la alteridad racial del agresor, atribución explícita de responsabilidad en el delito sufrido y menoscabo de la credibilidad de la denunciante, condicionado a la reiteración del término ‘presunto’ (Berganza, 2003; Carbadillo, 2010; Easteal, Holland y Judd, 2015; Escribano, 2014). Se comparará por primera vez el alcance de esos cuatro encuadres en violencias machistas con otros delitos que causan víctimas y necesitan de la denuncia de éstas (terrorismo, delitos de odio, siniestralidad laboral, seguridad vial, delitos contra la propiedad y violencia contra las personas sin componente de género). Se probará que la identificación más detallada de la denunciante, la alteridad racial del agresor y el menoscabo de la credibilidad de la denunciante son encuadres específicos a las violencias contra las mujeres. El estudio temporal (1996-2016) evidenciará, además, que se acentúan tras la aprobación de la legislación sobre igualdad.
Revisión bibliográfica de la marca corporativa: hacia una definición y gestión integradoras
Authors: Pereira-Villazón Tatiana , Portilla Idoia , Rodríguez-Salcedo Natalia 
Published: June 2021

La marca corporativa es un activo intangible y estratégico de gran valor que se vincula a conceptos como identidad e imagen. Esto le ha supuesto la atención de diversas disciplinas, no solo de la comunicación. El objetivo de este trabajo es identificar dichas disciplinas, autores destacados, ofrecer una definición integradora de la marca corporativa, identificar conceptos relacionados y el área a la que se asigna su gestión. Se trata de arrojar luz sobre la importancia de una adecuada gestión de la marca corporativa. Para ello, se ha realizado una revisión bibliográfica sistematizada de los trabajos académicos publicados durante el periodo 2016-2018. Sobre ellos se aplica un análisis de contenido cuantitativo y cualitativo. Tras la revisión de 112 publicaciones académicas en 66 revistas, se observa la escasa aportación del área de la comunicación en contraste con la gestión y el marketing, de donde proceden también los autores más citados. Respecto a la gestión de la marca corporativa, destaca el papel de la alta dirección y el área de marketing. La variedad temática de las aportaciones y el valor estratégico de la marca corporativa sugieren la necesidad de aportar un enfoque multidisciplinar en la gestión y estudio de la marca corporativa.
Effects of Theracurmin® consumption on liver function, fatigue, and sleep: a randomized, double-blind, placebo- controlled, parallel-comparison study
Authors: Kuwabara Yoshitaka , Hirose Akiko , Lee Hyunjin , Hashimoto Daisuke , Iio Shin-ichiro , Takara Tsuyoshi 
Published: June 2021

Objective: To evaluate the effects of the eight-week consumption of Theracurmin® on liver function, fatigue, and sleep.Methods: This was a randomized, double-blind, placebo-controlled, parallel-comparison study involving 68 healthy Japanese adults. Subjects were allocated into either the active (Theracurmin®) or placebo group (n = 34 each) using a random number generator. Subjects consumed two capsules per day of either the active or placebo food for eight weeks. The primary outcome was the serum alanine aminotransferase (ALT) levels at eight weeks, whereas the secondary outcomes were the biomarkers of liver function, comparison of the percentages of improvement in liver function based on the decision criteria, OSA sleep inventory MA version (OSA-MA), and visual analog scale of fatigue.Results: Each group included 33 subjects in the full analysis set. ALT levels in the per protocol set analysis, except for subjects drinking quantities of alcohol that increase the risk of lifestyle-related disease onset, showed a significant decrease in ALT compared to the placebo group (P < 0.05). The subjective symptom in the fatigue recovery factor of OSA-MA was significantly improved through the intervention (P < 0.05). The fatigue recovery effect of Theracurmin® was prominent in the subjects aged ≤ 45 years, the age group defined by the Ministry of Health, Labour and Welfare as middle-aged and older persons in the Act on Stabilization of Employment of Elderly. No adverse event was observed.Conclusions: These results suggest that the consumption of Theracurmin® or eight weeks improved liver function and fatigue recovery at awakening in healthy Japanese adults.Trial registration: UMIN-CTR: UMIN000039319.Foundation: Theravalues CorporationKeywords: highly bioavailable curcumin, liver function, alanine aminotransferase (ALT), OSA sleep inventory MA version, fatigue recovery
Accumulation of sugars and associated gene expression in highbush blueberries differ by cultivar, ripening stage, and storage temperature
Authors: Nguyen Chau Thi Thu , Lee Ji Hyun , Tran Phu-Tri 
Published: June 2021

BACKGROUND: The sweetness of highbush blueberries is a sensory quality standard for consumers. Changes in metabolites and expression of associated genes induce variation in the sensory quality of blueberries. OBJECTIVE: This work investigated the ripening mechanism of blueberries by measuring changes in organic acids and sugar content as well as the gene expression levels associated with sugar accumulation, such as β amylase, invertase, sucrose phosphate synthase, and tonoplast monosaccharide transporter genes, before and after harvesting. METHODS: We used three different blueberry cultivars (Duke, Sierra, and Elizabeth) that we harvested at two ripening stages in a randomized complete block design and then kept at room temperature or 4°C for 7 days. The organic acids and sugar content were measured via HPLC, and gene expression levels were analyzed by qPCR. RESULTS: Cultivars, ripening stage, and storage conditions affected the synthesis of sugars and degradation of organic acids to determine the sweetness in blueberries and the expression of tagged genes and analyses of compounds involved in the metabolic mechanism. CONCLUSIONS: The results provide insights into the mechanism underlying the ripening and the postharvest quality. This study may support the selection of suitable blueberry cultivars that meet customer demand.
Maternal diabetes and fetal cardiac output
Authors: Narasimhan S.L. , Eid A. , Bhatia A. , Davey C. , Steinberger J. 
Published: June 2021

BACKGROUND: The intrauterine environment is a key determinant for long-term health outcomes. Adverse fetal environments, such as maternal diabetes, obesity and placental insufficiency are strongly associated with long-term health risks in children. Little is known about differences in fetal cardiac output hemodynamics of diabetic mothers (DM) vs. non-diabetic mothers (NDM). Our study aims to investigate the left-sided, right-sided, and combined cardiac output (CCO) in fetuses of DM vs. NDM. METHODS: Retrospective data were collected in fetuses of DM (N = 532) and NDM (103) at mean gestational age 24 weeks. Examination included 2D echo and pulse wave Doppler. Wilcoxon rank sum tests and Chi-square tests were used to test for distribution difference of maternal and fetal continuous and categorical measures respectively between DM and NDM. Intraclass correlation coefficients were calculated to assess intra-observer reliability of fetal cardiac measurements. RESULTS: DM mothers had higher mean weight (89.7±22.2 kg) than NDM (76.8±19.8 kg), p < 0.0001 and higher mean BMI (33.4±7.5) than NDM (28.3±5.8), p < 0.0001. C-section delivery occurred in 66% of DM vs. 35% of NDM fetuses. Fetuses of DM mothers had significantly larger semilunar valve diameter, higher left ventricular (LV) output, higher combined cardiac output and lower right ventricle /left ventricle ratio compared to NDM. CONCLUSION: The greater CCO (adjusted for fetal weight), left sided cardiac output in the fetuses of DM, compared to NDM, represent differences in cardiac adaptation to the diabetic environment.
A gaming system with haptic feedback to improve upper extremity function: A prospective case series
Authors: Hernandez Hamilton , Poitras Isabelle , Fay Linda , Khan Ajmal , Roy Jean-Sébastien , Biddiss Elaine 
Published: June 2021

BACKGROUND: Video games can be used to motivate repetitive movements in paediatric rehabilitation. Most upper limb videogaming therapies do not however include haptic feedback which can limit their impact. OBJECTIVE: To explore the effectiveness of interactive computer play with haptic feedback for improving arm function in children with cerebral palsy (CP). METHODS: Eleven children with hemiplegic CP attended 12 therapist-guided sessions in which they used a gaming station composed of the Novint Falcon, custom-built handles, physical supports for the child’s arm, games, and an application to manage and calibrate therapeutic settings. Outcome measures included Quality of Upper Extremity Skills Test (QUEST) and Canadian Occupational Performance Measure (COPM). The study protocol is registered on clinicaltrials.gov (NCT04298411). RESULTS: Participants completed a mean of 3858 wrist extensions and 6665 elbow/shoulder movements during the therapist-guided sessions. Clinically important improvements were observed on the dissociated and grasp dimensions on the QUEST and the performance and satisfaction scales of the COPM (all [Formula: see text] 0.05). CONCLUSION: This study suggests that computer play with haptic feedback could be a useful and playful option to help improve the hand/arm capacities of children with CP and warrants further study. The opportunities and challenges of using low-cost, mainstream gaming software and hardware for therapeutic applications are discussed.
Ilmu Pengetahuan Dan Etika
Authors: Syabani Reza M. 
Published: June 2021

Ilmu pengetahuan berupaya mengungkapkan realitas sebagaimana adanya, etika dan moral pada dasarnya adalah petunjuk tentang apa yang seharusnya dilakukan manusia. Ilmu pengetahuan merupakan seluruh usaha sadar untuk menyelidiki, menemukan, dan meningkatkan pemahaman manusia dari berbagai segi kenyataan dalam alam manusia. Segi-segi ini dibatasi agar dihasilkan rumusan-rumusan yang pasti. Ilmu memberikan kepastian dengan membatasi lingkup pandangannya, dan kepastian ilmu-ilmu diperoleh dari keterbatasannya. Ilmu bukan sekedar pengetahuan (knowledge), tetapi merangkum sekumpulan pengetahuan berdasarkan teori-teori yang disepakati dan dapat secara sistematik diuji dengan seperangkat metode yang diakui dalam bidang ilmu tertentu.
Analisis Penerapan Proteksi Kebakaran terhadap Kerentanan Anak Sekolah di DKI Jakarta Tahun 2019
Authors: Hendrawati Lulus S , Husen Husen , Cahyono Agung 
Published: June 2021

Gedung sekolah merupakan sarana penting dalam proses pembelajaran anak-anak Indonesia. Dalam hal ini manajemen memiliki kewajiban untuk menjaga gedung sekolah dari kemungkinan terjadinya bencana, salah satunya adalah bencana kebakaran. Data kejadian kebakaran di Jakarta pada tahun 2018 masih cukup tinggi dengan jumlah kejadian 692 kejadian 6348 jiwa mengungsi. Maka penellitian ini bertujuan untuk mengetahui bagaimana penerapan proteksi kebakaran yang telah dilaksnakan di SDN 09 Makasar, Jakarta Timur. Metode Penelitian menggunakan desain kualitatif dengan Informan penelitian ini yaitu Kepala sekolah, guru, staf administrasi dan security, menggunakan data primer, instrument yang digunakan dengan wawan cara mendalam dan observasi lapangan. Hasil dari penelitian ini menunjukkan bahwa penerapan proteksi kebakaran di SDN 09 Makasar, Jakarta Timur masih belum terprogram dengan baik. Tenaga pendidik dan kependidikan belum pernah mengikuti pelatihan proteksi kebakaran dan sosialisai program pencegahan kebakaran sehingga mereka tidak memiliki kemampuan menggunakan alat proteksi kebakaran. Selain itu, belum adanya sistem proteksi kebakaran yang digunakan untuk pencegahan kebakaran pada bangunan gedung, berdampak terhadap keselamatan anak-anak yang menjadi siswa di sekolah tersebut.
Pengaruh Faktor Intrinsik dan Ekstrinsik terhadap Perilaku Merokok pada Siswa SMP Trisoko
Authors: Beda Ama Petrus Geroda , Rivanto Rinto , Ramon Vitalis 
Published: June 2021

Kebiasaan merokok remaja saat ini menjadi salah satu masalah utama di Indonesia. Remaja yang merokok kerap memulai pendidikannya di bangku SMP bahkan sebelum itu, tidak terkecuali remaja di SMP Trisoko. Penelitian ini menggunakan desain cross sectional yang bertujuan untuk mengetahui pengaruh faktor intrinsik dan ekstrinsik terhadap perilaku merokok siswa SMP Trisoko. Sampel dalam penelitian ini adalah total Populasi siswa laki-laki SMP Trisoko yang berjumlah 153 orang. Hasil penelitian secara bivariat ada ada 3 variabel yang berpengaruh terhadap perilaku merokok remaja SMP Trisoko yaitu sikap (Pv=0,016 dan OR=3,201), teman sebaya (Pv=0,048 dan OR=2,016) dan iklan rokok (Pv=0,001 dan OR=5,086). Selain itu ada 2 variabel yang tidak berpengaruh yaitu pengetahuan (Pv=0,153) dan pengaruh orang tua (Pv=0,121). Hasil multivariat menunjukkan bahwa, iklan menjadi variabel yang paling dominan mempengaruhi perilaku merokok pada remaja SMP Trisoko (Pv=0,015 dan OR=3,594). Perlu diterapkan larangan merokok bagi siswa, baik di sekolah maupun di luar sekolah dengan sanksi yang dibuat sedemikian rupa agar siswa takut melakukan kegiatan merokok. Selain itu pihak sekolah perlu membuat informasi peringatan larangan merokok dengan menggunakan gambar yang menarik yang dapat mengedukasi siswa. Hal ini sebagai salah satu cara untuk menghalau dominasi iklan rokok saat ini.
Intervensi Perilaku Berbasis Sekolah Dasar Melalui Permainan Ular dan Tangga untuk Mengurangi Sampah
Authors: Fitriyah Sukhriyatun , Rahmawati Ade 
Published: June 2021

Menjaga kebersihan lingkungan dapat ditanamkan sejak dini. Penyampaian promosi kesehatan dapat menggunakan media permainan, agar siswa dapat lebih mudah memahami dan tidak mengalami kebosanan. Media permainan yang digunakan dalam penelitian ini adalah permainan ular tangga. Tujuan dari peneltian ini untuk mengetahui adanya pengaruh permainan ular tangga terhadap perilaku siswa dalam membuang sampah. Metode penelitian adalah quasy experiment dengan one grup pretest post test. Populasi penelitian yaitu 2 sekolah, SDN Singaraja I&II dan SDN Singajaya I&II Indramayu sebanyak 239 siswa dan didapatkan responden sebanyak 207 siswa. Uji statistik dengan uji Wilcoxon Sign Rank. Hasil penelitian menunjukkan bahwa terdapat perubahan perilaku siswa tentang membuang sampah melalui media permainan ular tangga dengan nilai Pv=0,000. Permainan ular tangga efektif sebagai media edukasi dalam mengubah perilaku siswa terhadap membuang sampah.
Determinan Efektivitas Program Kader Kesehatan Remaja di SMAN 01 Dramaga Bogor
Authors: Nina Nina , Supriyatna Rahmat 
Published: June 2021

Permasalahan yang terjadi pada remaja lebih banyak karena kecenderungan untuk berperilaku berisiko. Pemerintah melalui Kemenkes RI mengembangkan Pelayanan Kesehatan Peduli Remaja (PKPR) di Puskesmas dengan pelayanan komprehensif seperti kegiatan Posyandu atau Kader Kesehatan Remaja (KKR) di lingkungan Sekolah. Penelitian ini bertujuan untuk mengetahui pengaruh promosi kesehatan, peran tenaga kesehatan, motivasi dan dukungan guru Bimbingan dan Konseling (BK) terhadap efektivitas program KKR di SMAN 01 Dramaga Bogor tahun 2020. Penelitian ini menggunakan metode kuantitatif dengan pendekatan cross sectional menggunakan analisis regresi logistik berganda. Penelitian dilaksanakan bulan Maret-Oktober 2020. Instrumen penelitian menggunakan kuisioner dalam format google form. Populasi penelitian ini adalah seluruh siswa SMAN 01 Dramaga yang aktif menjadi KKR dengan pengambilan sampel menggunakan metode incidental sampling dan diperoleh sebanyak 96 responden. Hasil analisis bivariat menunjukkan ada pengaruh promosi kesehatan (Pv=0,000; OR=5,070), tenaga kesehatan (Pv=0,011; OR=4.280), motivasi (Pv=0,000; OR=11,000) dan dukungan guru BK (p-value=0,010; OR=3.021) dengan efektivitas program KKR. Analisis multivariat menunjukkan bahwa promosi kesehatan menjadi variabel paling dominan yang berpengaruh terhadap efektivitas Program KKR (B=0,377; Pv=0,000). Diperlukan adanya tinjauan manajemen pelaksanaan program KKR yang disertai pemantauan dan evaluasi yang berkelanjutan kolaborasi dengan berbagai pihak untuk bekerjasama berinovasi mewujudkan efektivitas program KKR.
Diseño y validación de un instrumento para medir el nivel de conocimientos en bioseguridad de odontólogos en tiempos de COVID-19
Authors: Mezarina Mendoza Jhon Paul Iakov , Montenegro Muñoz Shirley Ivon , Carrasco Freitas María Del Carmen 
Published: June 2021

Objetivo: Diseñar y validar un instrumento para medir el nivel de conocimientos de los cirujanos dentistas sobre las medidas de bioseguridad en la atención odontológica durante la pandemia por COVID-19. Métodos: Estudio de tipo descriptivo y de corte transversal. Inicialmente se elaboró un instrumento basado en revisión bibliográfica de 41 ítems. La validación de contenido se realizó a través del “juicio de expertos”. Se seleccionaron 5 jueces, quienes revisaron el planteamiento de las preguntas según los criterios de pertinencia, relevancia y claridad. A través de la prueba V de Aiken se obtuvo, con el levantamiento de observaciones, 31 enunciados. La fiabilidad se evaluó mediante una prueba piloto, a través de la consistencia interna que se determinó con la prueba Kuder Richardson. Resultados: Se realizaron dos pruebas piloto; ambos grupos estuvieron compuestos por 30 odontólogos, entre especialistas y generales, además de magísteres. En el primer piloto se obtuvo un valor de 0.519 en el coeficiente Kuder Richardson, por lo que se levantaron observaciones, y en el segundo estudio piloto el valor fue de 0.714; siendo este valor considerado adecuado. Conclusión: El resultado obtenido por las diferentes vías para evaluar el test fue adecuado, consiguiendo un instrumento de 22 ítems, dividido en cinco dimensiones; siendo que es válido y confiable, justificando su uso y aplicación en el ámbito investigativo.