bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of disproportionately enlarged subarachnoid space hydrocephalus with cognitive deficit in a general population: the Ohasama study
Authors: Nishikawa Tomofumi , Akiguchi Ichiro , Satoh Michihiro , Hara Azusa , Hirano Mikio , Hosokawa Aya , Metoki Hirohito , Asayama Kei , Kikuya Masahiro , Nomura Kyoko , Hozawa Atsushi , Miyamatsu Naomi , Imai Yutaka , Ohkubo Takayoshi 
Published: August 2021

AbstractDisproportionately enlarged subarachnoid space hydrocephalus (DESH) is the characteristic feature of idiopathic normal pressure hydrocephalus. We aimed to characterize the prevalence, development, and association of DESH to cognitive deficit in a large population. We reviewed the data of 1384 subjects eligible for the present study among 1590 participants who underwent magnetic resonance imaging (MRI) in the Ohasama Study, a population-based study in Ohasama, Japan. The participants with Mini-Mental State Examination (MMSE) score <  = 25 were assumed to have cognitive deficit and DESH was evaluated by reviewing the MRIs. We assessed the association between DESH, Evans index (EI), and cognitive deficit using multivariate logistic regression models adjusted for relevant confounders. Furthermore, we evaluated the new development of DESH and the deterioration of cognitive function in the participants with DESH. There were nine participants with DESH (0.65%), seven of whom showed cognitive deficit. DESH was significantly associated with cognitive deficit in multivariate regression analyses (odds ratio; 8.50 [95% confidence interval: 1.61–44.88]). In the 669 participants who underwent follow-up MRI, we found four participants newly presenting with DESH; the development of DESH was observed before/after the presence of EI > 0.3. We also found two participants with existing DESH showing no remarkable worsening in MMSE and EI. The present study demonstrated a positive association between the presence of DESH and cognitive deficit. DESH can develop independently of EI > 0.3, and ventricular enlargement in combination with DESH may be an important factor in the worsening of cognitive deficit.
Association between glaucoma surgery and all-cause and cause-specific mortality among elderly patients with glaucoma: a nationwide population-based cohort study
Authors: Lee Sang Yeop , Lee Hun , Lee Ji Sung , Han Sol Ah , Kim Yoon Jeon , Kim Jae Yong , Tchah Hungwon 
Published: August 2021

AbstractThis population-based, retrospective cohort study aimed to evaluate the association between glaucoma surgery and all-cause and cause-specific mortality among Korean elderly patients with glaucoma. A total of 16210 elderly patients (aged ≥ 60 years) diagnosed with glaucoma between 2003 and 2012 were included, and their insurance data were analyzed. The participants were categorized into a glaucoma surgery cohort (n = 487), which included individuals who had diagnostic codes for open angle glaucoma (OAG) or angle closure glaucoma (ACG) and codes for glaucoma surgery, and a glaucoma diagnosis cohort (n = 15,723), which included patients who had codes for OAG and ACG but not for glaucoma surgery. Sociodemographic factors, Charlson Comorbidity Index score, and ocular comorbidities were included as covariates. Cox regression models were used to assess the association between glaucoma surgery and mortality. The incidence of all-cause mortality was 34.76/1,000 person-years and 27.88/1,000 person-years in the glaucoma surgery and diagnosis groups, respectively. The adjusted hazard ratio (HR) for all-cause mortality associated with glaucoma surgery was 1.31 (95% confidence interval [CI], 1.05–1.62, P = 0.014). The adjusted HR for mortality due to a neurologic cause was significant (HR = 2.66, 95% CI 1.18–6.00, P = 0.018). The adjusted HRs for mortality due to cancer (HR = 2.03, 95% CI 1.07–3.83, P = 0.029) and accident or trauma (HR = 4.00, 95% CI 1.55–10.34, P = 0.004) associated with glaucoma surgery for ACG were significant as well. Glaucoma surgery was associated with an increase of mortality in elderly patients with glaucoma. In particular, the risk of mortality associated with glaucoma surgery due to neurologic causes was significant.
Early warming stress on rainbow trout juveniles impairs male reproduction but contrastingly elicits intergenerational thermotolerance
Authors: Butzge Arno Juliano , Yoshinaga Tulio Teruo , Acosta Omar David Moreno , Fernandino Juan Ignacio , Sanches Eduardo Antônio , Tabata Yara Aiko , de Oliveira Claudio , Takahashi Neuza Sumico , Hattori Ricardo Shohei 
Published: August 2021

AbstractThe exposure of adult fish to warm or high temperatures is known to impair reproduction, yet the long-term reproductive impacts for treatments at early life are not well clarified. This study aimed to evaluate the effects of warm temperature (WT) during juvenile stage on gonad maturation, gamete quality, and offspring thermotolerance in rainbow trout. While the comparison of basic reproductive parameters in WT females did not reveal any kind of impairment, many WT males showed an atrophied, undeveloped gonad, or a smaller testis with lower milt volume; sperm quality parameters in WT males and deformity rates in the respective progeny were also highly affected. However, despite of such negative effects, many of the remaining progeny presented better rates of survival and growth when exposed to the same conditions as those of parental fish (WT), suggesting that thermal stress in parr stage males elicited intergenerational thermotolerance after a single generation. The present results support that prolonged warming stress during early life stages can adversely affect key reproductive aspects, but contrastingly increase offspring performance at upper thermal ranges. These findings have implications on the capacity of fish to adapt and to cope with global warming.
Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube
Authors: Yamagata Hirotaka , Kobayashi Ayumi , Tsunedomi Ryouichi , Seki Tomoe , Kobayashi Masaaki , Hagiwara Kosuke , Chen Chong , Uchida Shusaku , Okada Go , Fuchikami Manabu , Kamishikiryo Toshiharu , Iga Jun-ichi , Numata Shusuke , Kinoshita Makoto , Kato Takahiro A. , Hashimoto Ryota , Nagano Hiroaki , Okamoto Yasumasa , Ueno Shuichi , Ohmori Tetsuro , Nakagawa Shin 
Published: August 2021

AbstractCryopreservation of whole blood is useful for DNA collection, and clinical and basic research. Blood samples in ethylenediaminetetraacetic acid disodium salt (EDTA) tubes stored at − 80 °C are suitable for DNA extraction, but not for high-quality RNA extraction. Herein, a new methodology for high-quality RNA extraction from human blood samples is described. Quickly thawing frozen whole blood on aluminum blocks at room temperature could minimize RNA degradation, and improve RNA yield and quality compared with thawing the samples in a 37 °C water bath. Furthermore, the use of the NucleoSpin RNA kit increased RNA yield by fivefold compared with the PAXgene Blood RNA Kit. Thawing blood samples on aluminum blocks significantly increased the DNA yield by ~ 20% compared with thawing in a 37 °C water bath or on ice. Moreover, by thawing on aluminum blocks and using the NucleoSpin RNA and QIAamp DNA Blood kits, the extraction of RNA and DNA of sufficient quality and quantity was achieved from frozen EDTA whole blood samples that were stored for up to 8.5 years. Thus, extracting RNA from frozen whole blood in EDTA tubes after long-term storage is feasible. These findings may help advance gene expression analysis, as well as biomarker research for various diseases.
Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation
Authors: Xia Yuxing , Bell Brach M. , Giasson Benoit I. 
Published: August 2021

AbstractAlzheimer’s disease is the leading cause of dementia and a defining hallmark is the progressive brain deposition of tau aggregates. The insidious accumulation of brain tau inclusions is also involved in a group of neurodegenerative diseases termed frontotemporal dementias. In all of these disorders, tau aggregates are enriched in post-translational modifications including acetylation, which has recently been identified at multiple sites. While most evidence suggest that tau acetylation is detrimental and promotes tau aggregation, a few studies support that tau acetylation within the KXGS motif can be protective and inhibit tau aggregation. To model site-specific acetylation at K259, K290, K321, and K353, acetylmimetics were created by mutating lysine to glutamine residues, which approximates size and charge of acetylation. HEK293T cells were transfected to express wild type tau, tau pathogenic mutations (P301L and P301L/S320F) or tau acetylmimetics and assessed by cell-based assays for microtubule binding and tau aggregation. Acetylmimetics within the KXGS motif (K259Q, K290Q, K321Q, K353Q) leads to significant decreased tau–microtubule interactions. Acetylmimetics K321Q and K353Q within the context of the pathogenic P301L tau mutation strongly inhibited prion-like seeded aggregation. This protective effect was confirmed to decrease intrinsic aggregation of P301L/S320F tau double mutation. Surprisingly, K321Q and K353Q acetylmimetics altered the conformational structure of P301L/S320F tau to extensively impair Thioflavin S binding. Site-specific acetylation of tau at K321 and K353 could represent a natural protective mechanism against tau aggregation and could be a potential therapeutic target.
The effect of charge transfer transition on the photostability of lanthanide-doped indium oxide thin-film transistors
Authors: He Penghui , Xu Hua , Lan Linfeng , Deng Caihao , Wu Yongbo , Lin Yilong , Chen Siting , Ding Chunchun , Li Xiao , Xu Miao , Peng Junbiao 
Published: August 2021

AbstractAmorphous oxide semiconductors are promising for their use in thin-film transistor (TFT) devices due to their high carrier mobility and large-area uniformity. However, their commercialization is limited by the negative gate bias stress experienced under continuous light illumination. Here, we report an approach to improve the negative bias illumination stress (NBIS) stability of amorphous oxide semiconductors TFTs by using lanthanide-doped indium oxide semiconductors as the channel layer. The effect of different lanthanide dopants on performances of solution-processed Ln:In2O3 TFTs are investigated. All lanthanides exhibit strong suppression of oxygen vacancy, which shift the Von from −13.5 V of pure In2O3 TFT to −1~1 V of Ln:In2O3 TFTs (except Ce). However, only Pr:In2O3 and Tb:In2O3 TFTs exhibit much better NBIS stability with same ΔVon of −3.0 V, compared to much higher ΔVon of −7.9~−15.6 V for other Ln:In2O3 TFTs. Our comprehensive study reveals that praseodymium and terbium act as a blue light down-conversion medium with low charge transfer transition energy for lowing photosensitivity of oxide semiconductors.
Accounting in the CloudVeneto private cloud
Authors: Andreetto Paolo , Costa Fulvia , Crescente Alberto , Fantinel Sergio , Fanzago Federica , Lazzaro Loris , Mazzon Paolo Emilio , Menguzzato Matteo , Sella Gianpietro , Sgaravatto Massimo , Traldi Sergio , Verlato Marco , Zangrando Lisa 
Published: August 2021

CloudVeneto is a private cloud implemented as the result of merging two existing cloud infrastructures: the INFN Cloud Area Padovana, and a private cloud owned by 10 departments of University of Padova. This infrastructure is a full production facility, in continuous growth, both in terms of users, and in terms of computing and storage resources.
Even if the usage of CloudVeneto is not regulated by a strict pay-per-use model, the availability of accounting information for such infrastructure is a requirement, to detect if the resources allocated to the user communities are effciently used, and to perform an effective capacity planning.
We present in this paper how the accounting system used in CloudVeneto evolved over time, focusing on the accounting framework being used now, implemented by integrating existing components.
LHC Data Storage: Preparing for the Challenges of Run-3
Authors: Arsuaga-Rios Maria , Bahyl Vladimír , Batalha Manuel , Caffy Cédric , Cano Eric , Capitoni Niccolo , Contescu Cristian , Davis Michael , Fernandez Alvarez David , Guenther Jaroslav , Karavakis Edouardos , Keeble Oliver , Leduc Julien , Luchetti Fabio , Mascetti Luca , Murray Steven , Patrascoiu Mihai , Peters Andreas , Kamil Simon Michal , Sindrilaru Elvin , Toebbicke Rainer 
Published: August 2021

The CERN IT Storage Group ensures the symbiotic development and operations of storage and data transfer services for all CERN physics data, in particular the data generated by the four LHC experiments (ALICE, ATLAS, CMS and LHCb).
In order to accomplish the objectives of the next run of the LHC (Run-3), the Storage Group has undertaken a thorough analysis of the experiments’ requirements, matching them to the appropriate storage and data transfer solutions, and undergoing a rigorous programme of testing to identify and solve any issues before the start of Run-3.
In this paper, we present the main challenges presented by each of the four LHC experiments. We describe their workflows, in particular how they communicate with and use the key components provided by the Storage Group: the EOS disk storage system; its archival back-end, the CERN Tape Archive (CTA); and the File Transfer Service (FTS). We also describe the validation and commissioning tests that have been undertaken and challenges overcome: the ATLAS stress tests to push their DAQ system to its limits; the CMS migration from PhEDEx to Rucio, followed by large-scale tests between EOS and CTA with the new FTS “archive monitoring” feature; the LHCb Tier-0 to Tier-1 staging tests and XRootD Third Party Copy (TPC) validation; and the erasure coding performance in ALICE.
CERN Tape Archive: a distributed, reliable and scalable scheduling system
Authors: Cano Eric , Bahyl Vladimír , Caffy Cédric , Cancio Germán , Davis Michael , Keeble Oliver , Kotlyar Viktor , Leduc Julien , Murray Steven 
Published: August 2021

The CERN Tape Archive (CTA) provides a tape backend to disk systems and, in conjunction with EOS, is managing the data of the LHC experiments at CERN.Magnetic tape storage offers the lowest cost per unit volume today, followed by hard disks and flash. In addition, current tape drives deliver a solid bandwidth (typically 360MB/s per device), but at the cost of high latencies, both for mounting a tape in the drive and for positioning when accessing non-adjacent files. As a consequence, the transfer scheduler should queue transfer requests before the volume warranting a tape mount is reached. In spite of these transfer latencies, user-interactive operations should have a low latency.The scheduling system for CTA was built from the experience gained with CASTOR. Its implementation ensures reliability and predictable performance, while simplifying development and deployment. As CTA is expected to be used for a long time, lock-in to vendors or technologies was minimized.Finally, quality assurance systems were put in place to validate reliability and performance while allowing fast and safe development turnaround.
First experiences with a portable analysis infrastructure for LHC at INFN
Authors: Ciangottini Diego , Boccali Tommaso , Ceccanti Andrea , Spiga Daniele , Salomoni Davide , Tedeschi Tommaso , Tracolli Mirco 
Published: August 2021

The challenges proposed by the HL-LHC era are not limited to the sheer amount of data to be processed: the capability of optimizing the analyser's experience will also bring important benefits for the LHC communities, in terms of total resource needs, user satisfaction and in the reduction of end time to publication. At the Italian National Institute for Nuclear Physics (INFN) a portable software stack for analysis has been proposed, based on cloud-native tools and capable of providing users with a fully integrated analysis environment for the CMS experiment. The main characterizing traits of the solution consist in the user-driven design and the portability to any cloud resource provider. All this is made possible via an evolution towards a “python-based” framework, that enables the usage of a set of open-source technologies largely adopted in both cloud-native and data-science environments. In addition, a “single sign on”-like experience is available thanks to the standards-based integration of INDIGO-IAM with all the tools. The integration of compute resources is done through the customization of a JupyterHUB solution, able to spawn identity-aware user instances ready to access data with no further setup actions. The integration with GPU resources is also available, designed to sustain more and more widespread ML based workflow. Seamless connections between the user UI and batch/big data processing framework (Spark, HTCondor) are possible. Eventually, the experiment data access latency is reduced thanks to the integrated deployment of a scalable set of caches, as developed in the context of ESCAPE project, and as such compatible with the future scenarios where a data-lake will be available for the research community.
The outcome of the evaluation of such a solution in action is presented, showing how a real CMS analysis workflow can make use of the infrastructure to achieve its results.
Opportunistic transparent extension of a WLCG Tier 2 center using HPC resources
Authors: von Cube R. Florian , Caspart René , Fischer Max , Giffels Manuel , Kuehn Eileen , Quast Günter , Schnepf Matthias J. 
Published: August 2021

Computing resource needs are expected to increase drastically in the future. The HEP experiments ATLAS and CMS foresee an increase of a factor of 5-10 in the volume of recorded data in the upcoming years. The current infrastructure, namely the WLCG, is not sufficient to meet the demands in terms of computing and storage resources.
The usage of non HEP specific resources is one way to reduce this shortage. However, using them comes at a cost: First, with multiple of such resources at hand, it gets more and more diffcult for the single user, as each resource normally requires its own authentication and has its own way of accessing it. Second, as they are not specifically designed for HEP workflows, they might lack dedicated software or other necessary services.
Allocating the resources at the different providers can be done by COBalD/TARDIS, developed at KIT. The resource manager integrates resources on demand into one overlay batch system, providing the user with a single point of entry. The software and services, needed for the communities workflows, are transparently served through containers.
With this, an HPC cluster at RWTH Aachen University is dynamically and transparently integrated into a Tier 2 WLCG resource, virtually doubling its computing capacities.
Understanding ATLAS infrastructure behaviour with an Expert System
Authors: Asensi Ignacio , Rummler André , Solans Carlos , Andres Uribe Gustavo , Torres Jose 
Published: August 2021

The ATLAS detector requires a huge infrastructure consisting of numerous interconnected systems forming a complex mesh which undergoes constant maintenance and upgrades. The ATLAS Technical Coordination Expert System provides, by the means of a user interface, a quick and deep understanding of the infrastructure, which helps to plan interventions by foreseeing unexpected consequences, and to understand complex events when time is crucial in the ATLAS control room. It is an object-oriented expert system based on the knowledge composed of inference rules and information from diverse domains such as detector control and safety systems, gas, water, cooling, ventilation, cryogenics, and electricity distribution.
This paper discusses the latest developments in the inference engine and the implementation of the most probable cause algorithm based on them. One example from the annual maintenance of the 15°C water circuit chillers is discussed.
Observed risk of recurrent bleeding and thromboembolic disease in COVID-19 patients with gastrointestinal bleeding
Authors: Attah Emmanuel , Martin Tracey A. , Smith Emily S. , Tewani Sunena , Hajifathalian Kaveh , Sharaiha Reem Z. , Crawford Carl V. , Wan David 
Published: August 2021

Abstract
Background and study aim COVID-19 patients are at increased risk for venous thromboembolism (VTE) requiring the use of anticoagulation. Gastrointestinal bleeding (GIB) is increasingly being reported, complicating the decision to initiate or resume anticoagulation as providers balance the risk of thrombotic disease with the risk of bleeding. Our study aimed to assess rebleeding rates in COVID-19 patients with GIB and determine whether endoscopy reduces these rebleeding events. We also report 30-day VTE and mortality rates.
Methods This was a retrospective study evaluating 56 COVID-19 patients with GIB for the following outcomes: 30-day rebleeding rate, 30-day VTE rate, effects of endoscopic intervention on the rate of rebleeding, and 30-day mortality.
Results The overall rates of VTE and rebleeding events were 27 % and 41 %, respectively. Rebleeding rates in patients managed conservatively was 42 % compared with 40 % in the endoscopy group. Overall, 87 % of those who underwent invasive intervention resumed anticoagulation vs. 55 % of those managed medically (P = 0.02). The all-cause 30-day mortality and GIB-related deaths were 32 % and 9 %, respectively. Mortality rates between the endoscopic and conservative management groups were not statistically different (25 % vs. 39 %; P = 0.30).
Conclusions Although rebleeding rates were similar between the endoscopic and conservative management groups, patients who underwent intervention were more likely to restart anticoagulation. While endoscopy appeared to limit the duration that anticoagulation was withheld, larger studies are needed to further characterize its direct effect on mortality outcomes in these complex patients.
Update Phytotherapie – Aktueller wissenschaftlicher Stand bei Angst, Depression, innerer Unruhe und Schlafstörungen
Authors: Gündling Peter W. 
Published: August 2021

ZusammenfassungPsychische Erkrankungen und Belastungen sind weltweit auf dem Vormarsch. Aktuell beherrschen Ängste und deren Folgen ganze Bevölkerungsgruppen. Im Rahmen einer multimodalen Therapie können Phytopharmaka, für die es in den letzten Jahren zunehmend wissenschaftliche Belege gibt, neben Gesprächs- und Verhaltenstherapien eine wertvolle Hilfe sein. Der Beitrag geht auf die bekannten Phytotherapeutika ein und zeigt jedoch auch weniger bekannte Heilpflanzen mit anxiolytischer Wirkung auf.
Fetale Hypoxie und Apoptose nach maternaler Infektion mit dem PRRS-Virus
Authors: Schmid Sarah 
Published: August 2021

Malgarin CM, Moser F, Pasternak JA et al. Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection. BMC Vet Res 2021; 17: 182
Das Porzine Reproduktive und Respiratorische Syndrom gehört zu den bedeutendsten viralen Schweineerkrankungen und geht mit hohen wirtschaftlichen Verlusten einher. Etwa die Hälfte dieser Verluste ist durch Aborte, totgeborene oder lebensschwache Ferkel sowie Kümmerer auf die reproduktive Form der Erkrankung bei maternaler Infektion in der Spätträchtigkeit zurückzuführen. Die Mechanismen für den fetalen Tod nach maternaler Infektion sind noch weitgehend ungeklärt. Vermutet wird eine Hypoxie infolge von Nabelschnurläsionen oder Plazentaablösung durch Apoptose. Ziel der Studie war der Nachweis von Anzeichen für Apoptose sowie Hypoxie im fetalen Gewebe.