bluuebunny/crossref_metadata_2025_split huggingface dataset:
Could Broccoli and Cauliflower Influence the Dispersal Dynamics of Western Flower Thrips (Thysanoptera: Thripidae) to Lettuce in the Salinas Valley of California?
Authors: Joseph Shimat V , Koike Steven T 
Published: May 2021

Abstract
The western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), is an important, worldwide vector of two tospoviruses (Family Bunyaviridae; Genus Tospovirus), Impatiens necrotic spot virus (INSV) and Tomato spotted wilt virus (TSWV). In the Salinas Valley of California, INSV causes severe necrosis, stunting, and crop losses to lettuce (Lactuca sativa L.). Because broccoli (Brassica oleracea var. italica L.) and cauliflower (Brassica oleracea var. botrytis L.) are major rotation crops with lettuce in the Salinas Valley, it is critical to understand if these Brassicas influence the dispersal dynamics of F. occidentalis. In 2013 and 2014, surveys were conducted evaluating yellow sticky cards and plant samples in lettuce, broccoli, and cauliflower fields in three regions of the Salinas Valley. F. occidentalis were collected on sticky cards from April to November and on foliage in all three regions. Two-choice oviposition assays as well as no-choice and two-choice feeding assays were conducted where F. occidentalis adults were exposed to leaves of lettuce, broccoli, and cauliflower. A significantly greater number of eggs was found on lettuce than on broccoli or cauliflower leaves in the choice assay, whereas for the broccoli and cauliflower choice assay, the number of eggs retrieved was low and not significantly different between hosts. The number of F. occidentalis feeding spots and leaf area injury ratings were similar on broccoli and lettuce leaves but were significantly lower on cauliflower than on lettuce and broccoli leaves. The implications of these results on thrips and plant virus management are discussed.
Pulmonary valve replacement may not restore ventricular volume and functional status in patients with pulmonary regurgitation after late tetralogy of Fallot repair
Authors: Kim Woojung , Kwak Jae Gun , Kwon Hye Won , Cho Sungkyu , Kim Woong-Han , Lee Jeong Ryul , Min Jooncheol 
Published: May 2021

Abstract

OBJECTIVES
Clinically, tetralogy of Fallot (TOF) patients who underwent repair late (older than 2 years) appears to have worse outcomes after pulmonary valve replacement than patients who underwent repair early. We proceeded to review the clinical features of late-repaired TOF patients who required pulmonary valve replacement.

METHODS
Fifty patients who underwent pulmonary valve replacement after TOF repair over the age of 2 years from 2000 to 2018 were retrospectively reviewed. Pre- and postoperative cardiac magnetic resonance imaging, cardiopulmonary exercise tests, and cardiac catheterization were analysed.

RESULTS
The median age of patients at the time of TOF repair and pulmonary valve replacement was 3.6 and 23.4 years, respectively. The median interval from TOF repair to pulmonary valve replacement was 20.5 years. Cardiac magnetic resonance imaging and cardiopulmonary exercise tests were performed at a median of 5.9 and 3.7 years after pulmonary valve replacement, respectively. Cardiac magnetic resonance revealed that there were significant changes in the indexed values of the right ventricle end-diastolic volume (164.7–106.9 ml/m2, P &lt; 0.001), end-systolic volume (101.4–64.9 ml/m2, P &lt; 0.001), stroke volume (66.8–48.0 ml/m2, P = 0.007) and cardiac output (5.1–3.6 l/m2, P = 0.040). Twenty-eight percentage of patients achieved normalization of the right ventricular volume after pulmonary valve replacement. In the exercise test, the maximum rate of oxygen consumption (72.5–69.5%) and oxygen pulse (95.0–83.0%) changed without statistical significance.

CONCLUSIONS
Although pulmonary valve replacement after late TOF correction improves right ventricular volume status, only a minority of patients achieve normalization of right ventricular end systolic volume and a normal functional status.
Trends in the Use of Residential Settings Among Older Adults
Authors: Toth Matt , Palmer Lauren , Bercaw Lawren , Voltmer Helena , Karon Sarita L 
Published: May 2021

Abstract

Objectives
As the U.S. population ages, the prevalence of disability and functional limitations, and demand for long-term services and supports (LTSS), will increase. This study identified the distribution of older adults across different residential settings, and how their health characteristics have changed over time.

Methods
A cross-sectional analysis of older adults residing in traditional housing, community-based residential facilities (CBRFs), and nursing facilities using 3 data sources: the Medicare Current Beneficiary Survey (MCBS), 2008 and 2013; the Health and Retirement Study (HRS), 2008 and 2014; and the National Health and Aging Trends Study, 2011 and 2015. We calculated the age-standardized prevalence of older adults by setting, functional limitations, and comorbidities and tested for health characteristics changes relative to the baseline year (2002).

Results
The proportion of older adults in traditional housing increased over time, relative to baseline (p &lt; .05), while the proportion of older adults in CBRFs was unchanged. The proportion of nursing facility residents declined from 2002 to 2013 in the MCBS (p &lt; .05). The prevalence of dementia and functional limitations among traditional housing residents increased, relative to the baseline year in the HRS and MCBS (p &lt; .05).

Discussion
The proportion of older adults residing in traditional housing is increasing, while the nursing facility population is decreasing. This change may not be due to better health; rather, older adults may be relying on noninstitutional LTSS.
What’s in a Name? The Journey of Geographical Indications from Paris 1883 to Geneva 2015
Authors: Lightbourne Muriel 
Published: May 2021

Abstract
While the negotiations on geographical indications within the World Trade Organization have been stalled since their inception in 1996, many new developments resulting from bilateral or regional endeavours may be observed in this field. The present article will first briefly retrace the evolution of the concept and recall the different entrenched positions within the World Trade Organization (WTO). It will then show the impact of WTO Dispute Settlement Body (DSB) reports on the European Union system and discuss the recent bilateral agreements between China and the European Union on one side, and the United States of America on the other. It will also look at the entry into force of the Geneva Act of the Lisbon Agreement on appellations of origin and geographical indications. Whether the latter will manage to bridge the divide between the countries that promote the sui generis model of protection of indications of origin and common law jurisdictions remains to be seen, as does the outcome of the discussions on geographical indications and place names within the Internet Corporation for Assigned Names and Numbers.
Critical collaboration model: an enhanced model to support public health collaboration
Authors: Nicholas Graeme , Sharma Sudesh , Walton Mat , Hepi Maria , Hide Sophie 
Published: May 2021

Summary
Public health problems are often complex and ‘wicked’ in nature. Wicked problems have multi-factorial causation, are dynamic and often understood and acted upon differently by different actors. Multi-sectoral collaboration is increasingly emphasized for tackling wicked problems through developing a strategic multi-sectoral plan and then taking collective action. Critical systems thinking can support the development of a shared perspective of the problem, strengthen participation in collective action and foster reflective practices to continuously improve both problem understanding and action. In this paper, we present a critical collaboration model, drawing together two complementary theoretical frameworks, as well as insights from three case studies from New Zealand, to offer a systematic approach to adopting a critical systems perspective in public health collaboration. The model provides six questions to make explicit individuals’ understandings or assumptions about how others perceive an issue, problem or evidence, and the process of identifying answers strengthens the dialogical and reflective aspects of the collaboration. We indicate some potential areas for the application of the model to integrate critical systems thinking in collaborative practices.
Point Spectrum of Periodic Operators on Universal Covering Trees
Authors: Banks Jess , Garza-Vargas Jorge , Mukherjee Satyaki 
Published: May 2021

Abstract
For any multi-graph $G$ with edge weights and vertex potential, and its universal covering tree ${\mathcal{T}}$, we completely characterize the point spectrum of operators $A_{{\mathcal{T}}}$ on ${\mathcal{T}}$ arising as pull-backs of local, self-adjoint operators $A_{G}$ on $G$. This builds on work of Aomoto, and includes an alternative proof of the necessary condition for point spectrum derived in [ 5]. Our result gives a finite time algorithm to compute the point spectrum of $A_{{\mathcal{T}}}$ from the graph $G$, and additionally allows us to show that this point spectrum is itself contained in the spectrum of $A_{G}$. Finally, we prove that typical pull-back operators have a spectral delocalization property: the set of edge weight and vertex potential parameters of $A_{G}$ giving rise to $A_{{\mathcal{T}}}$ with purely absolutely continuous spectrum is open, and its complement has large codimension.
Breaking the Myth of Cyber Doom: Securitization and Normalization of Novel Threats
Authors: Gomez Miguel Alberto , Whyte Christopher 
Published: May 2021

Abstract
Physical damage resulting from cyber operations continues to reinforce the “cyber doom” narrative across societies dependent on information and communication technology. This is paradoxical given the absence of severe, lasting consequences from cyber operations and the relative restraint exercised by cyber-capable actors. Moreover, the mass adoption of vulnerable digital systems raises questions whether or not individuals’ dread cyber insecurity is as severe as we are often asked to believe. Employing a survey experiment, we find that the assumptions of the “cyber doom” narrative are misleading. While sensitivity to cybersecurity threats is shaped by negative information, the onset of panic and dread is not a given. The impact of novel environmental circumstances on opinion formation is shaped by the individuals’ embeddedness in modern digital society. Consequently, long-term exposure to any invasive development mitigates the emotional response associated with it, normalizing novel threats over time. We present evidence suggesting that the unique characteristics of a development (i.e., web-technology proliferation) matter in opinion formation, as sensitivity to digital threats to the polity is grounded on personal threat sensitivity. Thus, policymakers can expect to see public responses to new national security threats manifest through the lens of prevailing social and political narratives.
Why Does Aid Not Target the Poorest?
Authors: Briggs Ryan C 
Published: May 2021

Abstract
Foreign-aid projects typically have local effects, so they need to be placed close to the poor if they are to reduce poverty. I show that, conditional on local population levels, World Bank (WB) project aid targets richer parts of countries. This relationship holds over time and across world regions. I test five donor-side explanations for pro-rich targeting using a pre-registered conjoint experiment on WB Task Team Leaders (TTLs). TTLs perceive aid-receiving governments as most interested in targeting aid politically and controlling implementation. They also believe that aid works better in poorer or more remote areas, but that implementation in these areas is uniquely difficult. These results speak to debates in distributive politics, international bargaining over aid, and principal-agent issues in international organizations. The results also suggest that tweaks to WB incentive structures to make ease of project implementation less important may encourage aid to flow to poorer parts of countries.
Prevalence of genotypic baseline risk factors for cabotegravir + rilpivirine failure among ARV-naive patients
Authors: Charpentier Charlotte , Storto Alexandre , Soulié Cathia , Ferré Valentine Marie , Wirden Marc , Joly Véronique , Lambert-Niclot Sidonie , Palich Romain , Morand-Joubert Laurence , Landman Roland , Lacombe Karine , Katlama Christine , Ghosn Jade , Marcelin Anne-Geneviève , Calvez Vincent , Descamps Diane 
Published: May 2021

Abstract

Background
Multivariable baseline factor analysis across cabotegravir + rilpivirine clinical trials showed that HIV-1 subtypes A6/A1 and the presence of rilpivirine resistance-associated mutations (RAMs) were associated with an increased risk of virological failure of this dual therapy. The aim of this study was to describe the prevalence of genotypic baseline risk factors for cabotegravir + rilpivirine failure among ARV-naive patients.

Patients and methods
From 2010 to 2020, 4212 sequences from ARV-naive patients were collected from three large Parisian academic hospital genotypic databases. Cabotegravir and rilpivirine RAMs were defined according to the ANRS algorithm.

Results
Among 4212 ARV-naive patients, 38.6% were infected with subtype B, 32.4% with CRF02_AG (32.4%) and 5.1% with subtype A (85.5% being A6/A1 subtype). Overall, the presence of at least one cabotegravir or rilpivirine RAM was 16.2% and 14.3%, respectively. Considering genotypic resistance interpretation, using the ANRS algorithm, 0.74% (n = 31), 6.2% (n = 261) and 0.09% (n = 4) of sequences were resistant to cabotegravir, rilpivirine or both, respectively. The overall prevalence of L74I in integrase and E138A in RT was 13.0% and 3.2%, respectively, and stable over the decade. Thus, adding 183 subtype A6/A1 sequences to 244 sequences interpreted as resistant to rilpivirine led to 427 (10.1%) sequences combining both baseline virological risk factors for cabotegravir + rilpivirine dual-therapy failure.

Conclusions
Among large sequence databases, when adding prevalence of rilpivirine-resistant viruses and HIV-1 subtype A6/A1 sequences, 10.1% of patients would not be eligible for cabotegravir + rilpivirine dual therapy. These data re-emphasize the need for a pre-therapeutic genotypic resistance test to detect polymorphisms and transmitted drug resistance and to define HIV-1 subtype.
Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy
Authors: Lemaitre Florian , Locher Clara , Verdier Marie-Clémence , Naudet Florian 
Published: May 2021

Abstract
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, clinical trials on antiviral or symptomatic drugs have been conducted very rapidly even for drugs with a poor pharmacological rationale for efficacy on SARS-CoV-2. Despite lacking basic pharmacological information, most of these clinical trials were also extremely redundant. Applying simple rules, (such as identifying a mechanistic rationale, confirming the ability to reach exposure targets at therapeutic dosage and ensuring tests show drug efficacy in appropriate in vitro and animal models before entering clinical trials) might have saved considerable amounts of time and money, and might have avoided useless research. Moreover, combining these simple rules with the implementation of a relevant policy at both an international and a national level, by limiting studies with a poor methodological/scientific approach and aggregating studies with similar design into single clinical trials, is potentially a far more-efficient strategy.
Genetic potential for residual feed intake and diet fed during early- to mid-gestation influences post-natal DNA methylation of imprinted genes in muscle and liver tissues in beef cattle
Authors: Devos Julia , Behrouzi Amir , Paradis Francois , Straathof Christina , Li Changxi , Colazo Marcos , Block Hushton , Fitzsimmons Carolyn 
Published: May 2021

Abstract
Discovery of epigenetic modifications associated with feed efficiency or other economically important traits would increase our understanding of the molecular mechanisms underlying these traits. In combination with known genetic markers, this would provide opportunity to improve genomic selection accuracy in cattle breeding programs. It would also allow cattle to be managed to improve favorable gene expression. The objective of this study was to identify variation in DNA methylation between beef cattle of differential pre-natal nutrition and divergent genetic potential for residual feed intake (RFI). Purebred Angus offspring with the genetic potential for either high (HRFI) or low (LRFI) RFI were prenatally exposed to either a restricted maternal diet of 0.5 kg/d average daily gain (ADG) or a moderate maternal diet of 0.7 kg/d ADG from 30 to 150 d of gestation. We performed DNA methylation analysis of differentially methylated regions (DMR) of imprinted genes (Insulin-like growth factor 2 (IGF2) DMR2, IGF2/H19 imprinting control region (ICR) and IGF2 receptor (IGF2R) DMR2) using post-natal samples of longissimus dorsi (LD) muscle taken from male and female calves at birth and weaning, and of LD muscle, semimembranosus (SM) muscle, and liver samples collected from steers at slaughter (17 months of age). Interestingly, for all three DMR investigated in liver, LRFI steers had higher levels of methylation than HRFI steers. In LD muscle, IGF2/H19 ICR methylation differences for heifers at birth were due to pre-natal diet, while for steers at birth they were mostly the result of genetic potential for RFI with LRFI steers again having higher levels of methylation than HRFI steers. While results from repeated measures analysis of DNA methylation in steers grouped by RFI revealed few differences, in steers grouped by diet, we found higher methylation levels of IGF2 DMR2 and IGF2R DMR2 in LD muscle of restricted diet steers at weaning and slaughter than at birth, as well as increased methylation in LD muscle of restricted diet steers compared with moderate diet steers at weaning and/or slaughter. Our results suggest that differential pre-natal nutrition, and divergent genetic potential for RFI, induces tissue- and sex-specific alterations in post-natal IGF2 and IGF2R methylation patterns and that these patterns can vary with age in Angus beef cattle.
Oxidative stress and postmortem meat quality in crossbred lambs
Authors: Herrera Nicolas J , Bland Nicolas A , Ribeiro Felipe A , Henriott Morgan L , Hofferber Eric M , Meier Jakob , Petersen Jessica L , Iverson Nicole M , Calkins Chris R 
Published: May 2021

Abstract
The objective of this study was to evaluate effects of different levels of lipopolysaccharide (LPS)-mediated oxidative stress on fresh meat quality. Crossbred lambs (n = 29) were blocked by weight and fed a standard finishing ration for the duration of the study. Lambs were individually housed and treatment groups were administered one of three intravenous injections every 72 h across a three-injection (9-day) cycle: saline control (control), 50 ng LPS/kg body weight (BW) (LPS50), or 100 ng LPS/kg BW (LPS100). Rectal temperatures were measured to indicate inflammatory response. Lambs were harvested at the Loeffel Meat Laboratory and 80 mg of pre-rigor Longissimus lumborum were collected in control and LPS100 treatments within 30 min postmortem for RNA analysis. Wholesale loins were split and randomly assigned 1 or 14 d of wet aging. Chops were fabricated after aging and placed under retail display (RD) for 0 or 7 d. Animal was the experimental unit. LPS-treated lambs had increased (P &lt; 0.05) rectal temperatures at 1, 2, 4, and 24 h post-injection. Transcriptomics revealed significant (Praw &lt; 0.05) upregulation in RNA pathways related to generation of oxidative stress in LPS100 compared with control. A trend was found for tenderness (Warner–Bratzler shear force, WBSF; P = 0.10), chops from LPS50 having lower shear force compared with control at 1 d postmortem. Muscle from LPS50 treatment lambs exhibited greater troponin T degradation (P = 0.02) compared with all treatments at 1 d. Aging decreased WBSF (P &lt; 0.0001), increased sarcoplasmic calcium concentration (P &lt; 0.0001), pH (P &lt; 0.0001), and proteolysis (P &lt; 0.0001) across treatments. Following aging, chops increased discoloration as RD increased (P &lt; 0.0001), with control chops aged 14 d being the most discolored. Chops from lambs given LPS had higher (P &lt; 0.05) a* values compared with control at 14 d of aging. The L* values were greater (P &lt; 0.05) in LPS100 compared with both LPS50 and control. Aging tended (P = 0.0608) to increase lipid oxidation during RD across either aging period. No significant differences (P &gt; 0.05) in sarcomere length, proximate composition, fatty acid composition, or isoprostane content were found. These results suggest that defined upregulation of oxidative stress has no detriment on fresh meat color, but may alter biological pathways responsible for muscle stress response, apoptosis, and enzymatic processes, resulting in changes in tenderness early postmortem.
Population Dynamics and Reproductive Developmental Analysis ofHelicoverpa armigera(Lepidoptera: Noctuidae) Trapped Using Food Attractants in the Field
Authors: He Wei , Zhao Xincheng , Ali Abid , Ge Shishuai , Zhang Haowen , He Limei , Wu Kongming 
Published: May 2021

AbstractMonitoring adult populations of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae), a major agricultural pest, provides data useful for its control. Food attractants, considered as adult insect behavior regulators based on the preference of an herbivorous pest for food sources or their volatiles, also have great potential for monitoring populations. To study the feasibility of monitoring the population dynamics and reproductive development of H. armigera in the field using food attractants, we quantitatively analyzed reproductive organ development of adults in a laboratory population as a way to predict the reproductive development of adults trapped using food attractants in the field in 2019 and 2020. The adults trapped using food attractants had obvious generational changes and the same trends in variation for females and males. The extent of ovarian development in trapped females tended to increase within each generation, and the major axis length of testis in trapped males tended to decrease. Reproductive developmental status of trapped adults also differed significantly among months. This study shows that by trapping H. armigera with food attractants, the population dynamics of adults in the field can be monitored, and reproductive anatomy can also be used to monitor adult reproductive status. These approaches are a new way to forecast the population dynamics of this pest.