bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional and Structural Correlates of Glomerulosclerosis after Renal Mass Reduction in the Rat
Authors: GRIFFIN KAREN A. , PICKEN MARIA M. , CHURCHILL MONIQUE , CHURCHILL PAUL , BIDANI ANIL K. 
Published: April 2021

Abstract.
Previously, it was shown that 5/6 renal mass reduction by surgical excision (RK-NX) results in a marked reduction of glomerulosclerosis (GS) at 6 wk compared with the conventional 5/6 renal ablation by infarction (RK-I) model. To determine the pathogenetic correlates of the striking differences in GS, radiotelemetrically measured BP; single nephron function; glomerular volume; the temporal expression of mRNA for renin, transforming growth factor-β, and platelet-derived growth factor-B; and plasma renin concentration were compared between RK-NX, RK-I, and sham-operated control rats. Hypertension only developed in the RK-I model, was present at 3 d after infarction, and was correlated with both an increased expression of renin mRNA by Northern analysis and elevated plasma renin concentration. Structural (glomerular volume) and functional (single nephron blood flow and GFR) indices of the compensatory adaptive response were significantly but similarly increased in the RK-NX and RK-I rats compared with sham-operated controls, indicating that these adaptations per se are not responsible for the initiation of GS after 5/6 renal mass reduction. Glomerular capillary pressure (P
GC) was also significantly increased in both RK-I (56 ± 2 mmHg) and RK-NX rats (50 ± 0.9 mmHg) compared with controls (46 ± 0.8 mmHg, P < 0.01), but the increase was significantly greater in RK-I versus RK-NX rats (P < 0.05) consistent with the higher BP in RK-I rats. These data indicate that differences in renin probably account for the early divergence of BP (and P
GC) responses between RK-I and RK-NX models. Transforming growth factor-β and platelet-derived growth factor-B mRNA expression in pooled RNA from kidneys from each group showed increases at 21 d along with early evidence of glomerular injury in the RK-I group but not in the RK-NX group, consistent with their postulated roles as molecular mediators of GS, but only in rats with pathologic glomerular hypertension.
Cyclopentenone Prostaglandins Inhibit Cytokine-Induced NF-κB Activation and Chemokine Production by Human Mesangial Cells
Authors: ROVIN BRAD H. , LU LING , COSIO ANNA 
Published: April 2021

Abstract.
In the kidney an uncontrolled inflammatory response to an acute insult may lead to chronic inflammation, permanent tissue damage, and progressive renal insufficiency. Resolution of acute inflammation likely is dependent on endogenous regulatory mechanisms activated in parallel with mediators of renal inflammation. These mechanisms are postulated to attenuate the renal expression of proinflammatory cytokines, including the chemokines responsible for recruiting leukocytes to the kidney, thus facilitating the transition from inflammation to healing. To understand the regulation of the inflammatory response within the kidney, the effects of anti-inflammatory J series cyclopentenone prostaglandins on chemokine production by human mesangial cells were examined. Treatment of mesangial cells with prostaglandin J2 and 15-deoxy-Δ12,14-prostaglandin J2 blocked interleukin-1β—induced monocyte chemoattractant protein-1 mRNA expression and protein production. This correlated with failure of the transcription factor nuclear factor-κB (NF-κB) to translocate to the nucleus and bind to its recognition motif, a step required for cytokine-induced monocyte chemoattractant protein-1 gene activation. NF-κB failed to translocate because the cyclopentenone prostaglandins attenuated degradation of the NF-κB inhibitor IκB-α. These data suggest that certain prostaglandins can limit the extent of renal chemokine expression and thus may have an important role in resolving renal inflammation.
Earthquake Recurrence Model for the Colombia–Ecuador Subduction Zone Constrained from Seismic and Geodetic Data, Implication for PSHA
Authors: Mariniere Judith , Beauval Céline , Nocquet Jean-Mathieu , Chlieh Mohamed , Yepes Hugo 
Published: April 2021

ABSTRACTProbabilistic seismic hazard assessment relies on long-term earthquake forecasts and ground-motion models. Our aim is to improve earthquake forecasts by including information derived from geodetic measurements, with an application to the Colombia–Ecuador megathrust. The annual rate of moment deficit accumulation at the interface is quantified from geodetically based interseismic coupling models. We look for Gutenberg–Richter recurrence models that match both past seismicity rates and the geodetic moment deficit rate, by adjusting the maximum magnitude. We explore the uncertainties on the seismic rates (a- and b-values, shape close to Mmax) and on the geodetic moment deficit rate to be released seismically. A distribution for the maximum magnitude Mmax bounding a series of earthquake recurrence models is obtained for the Colombia–Ecuador megathrust. Models associated with Mmax values compatible with the extension of the interface segment are selected. We show that the uncertainties mostly influencing the moment-balanced recurrence model are the fraction of geodetic moment released through aseismic processes and the form of the Gutenberg–Richter model close to Mmax. We combine the computed moment-balanced recurrence models with a ground-motion model, to obtain a series of uniform hazard spectra representative of uncertainties at one site on the coast. Considering the recent availability of a massive quantity of geodetic data, our approach could be used in other well-instrumented regions of the world.
Legibilidad y disfrute de la literatura sexual española (una teoría historicista y sus proyecciones) : Artículo-reseña sobre Gaspar Garrote Bernal, Con dos poéticas. Teoría historicista de la literatura sexual española, Valladolid, Agilice Digital, 2020, 296 pp. = Legibility and enjoyment of Spanish sexual literature (a historical theory and its proyections) : Article-review about Gaspar Garrote Bernal, Con dos poéticas. Teoría historicista de la literatura sexual española, Valladolid, Agilice Digital, 2020, 296 pp
Authors: Lara Garrido José 
Published: April 2021

Revisión crítica y comentada del libro de Gaspar Garrote recientemente publicado, Con dos poéticas. Teoría historicista de la literatura sexual española (2020). Critical and commented review of the recently published book by Gaspar Garrote, Con dos poéticas. Teoría historicista de la literatura sexual española (2020).
Unusual manifestations of malaria in children
Authors: Agarwal Neha , Taneja Sunil 
Published: April 2021

Background: Till recently, vivax malaria was being regarded as a “benign” disease. Falciparum malaria is known to be a serious illness with life threatening complications as cerebral malaria, jaundice, acute kidney injury, metabolic acidosis and bleeding diatheses. Recently, some other atypical presentations are also, being noted, which have hardly been discussed previously. The present report highlights the various unusual presentations of malaria in children.Methods: The study design was hospital based prospective observational study conducted over one year. Children between the ages of 1 month to 18 years admitted with a diagnosis of malaria confirmed by peripheral blood smear examination and/or rapid diagnostic test having unusual manifestations were studied. Patients with dengue fever, enteric fever, viral hepatitis, or any other infection were excluded. The various unusual manifestations of malaria, disease course and outcome were analysed.Results: 58 (27.1%) out of 214 patients studied were found to have atypical manifestations. The unusual features observed were ARDS in vivax malaria (n=11), fulminant hepatic failure (n=5), post malaria neurological syndrome (n=3), stroke (n=3), bilateral optic neuritis (n=1), abducens nerve palsy (n=1), autoimmune haemolytic anemia (n=1), nephrotic syndrome (n=1), splenic infarction (n=2), acute abdomen (n=2), hemiplegia (n=2), psychomotor agitation (n=7), sepsis (n=5), shock (n=3), disseminated intravascular coagulation (n=3) and urticaria (n=2). Six children with vivax presented in deep coma.Conclusions: Clinicians in endemic areas should be aware of unusual and varied presentations of malaria; failure of recognition of which may lead to delayed diagnosis resulting in increased mortality.
Investigating Suitable Multiple Access Techniques for Harbor Wireless Communication Systems
Authors: Fitriyani Enadevita , Anwar Khoirul , Andriansyah Nachwan Mufti 
Published: April 2021

The multiple access communications for harbor environment are suffering from both low quality transmission due many metallic obstacles and overloaded networks due to the huge number of users/devices of logistic monitoring. This paper proposes a coded random access (CRA) scheme with a degree distribution suitable for harbor environment to serve many devices and provide communications with high reliability. The degree distribution is optimized using extrinsic information transfer (EXIT) charts by keeping that two EXIT curves do not intersect at low mutual information points. Since we are working on the network level, of which the benefit of broadband communications is kept for the fairness with the narrowband transmission, we convert the gain of broadband transmissions into an equivalent gain to the narrowband transmissions based on the Shannon channel capacity and coding theory. We then compare CRA to carrier sense multiple access with collision avoidance (CSMA/CA), because CSMA/CA has better performance compared to other techniques, such as ALOHA and Slotted ALOHA. We evaluate the performance of the proposed CRA and CSMA/CA using a series of computer simulation in additive white Gaussian noise (AWGN) and multipath Rayleigh fading channels in terms of throughput and packet-loss rate (PLR). The results confirmed that CRA with the proposed degree distribution is more suitable than CSMA/CA as a multiple access technique for harbor wireless communications, indicated that the proposed CRA has higher throughput and lower PLR. The results of this study are expected to contribute to the development of future harbor communication systems.
Phytoremediation by Echinodorus palaefolius to Reduce Nitrogen and Phosphate Waste of Intensive Culture Anguilla bicolor in Recirculation Aquaculture Systems
Authors: Handajani Hany , Widanarni - , Budiardi Tatag , Setiawati Mia 
Published: April 2021

Increase in aquaculture activities leads to a negative impact on the environment. Thus, phytoremediation through recirculation aquaculture system becomes one effort that can be applied. The study aimed to evaluate the administration of Echinodorus palaefolius (water jasmine plant) through increasing the capacity of plants as phytoremediators in reducing the waste of intensive culture eel. This study used a completely randomized design with three treatments of E. palaefolius density and repeated 3 times, as treatments were 1.04 g L-1 (Ep1), 2.08 g L-1 (Ep2), and 3.13 g L-1 (Ep3). The initial average eel weight was 8.3 ± 0.13 g, with a stocking density of 4 g L-1. The results showed a significant difference in the effect of E. palaefolius density on nutrient removal efficiency, as well as performance on eel and plant growth. The highest efficiency of nutrient removal in E. palaefolius with a density of 2.08 g L-1, nitrite (49.65 ± 4.52) %, nitrate (59.62 ± 1.89) %, phosphate (60.88 ± 1. 03) %, and TAN (46.03 ± 0.63) %. At E. palaefolius density 2.08 g L-1 produced eel specific growth rates (0.99 ± 0.02) % lowest feed conversion (1.97 ± 0.03), and highest increase of E. palaefolius biomass (262, 33 ± 2.60 g with daily growth 4.37 ± 0.43 g day-1). Thus, it can be concluded that the density of E. palaefolius 2.08 g L-1 produces the best efficiency in removing nutrients, the growth performance of eels and plants.
Insurreições estéticas e performances na Amazônia brasileira: notas para uma reflexão decolonial (Edição 485)
Authors: Latif Larissa 
Published: April 2021

A crítica decolonial tem, nestas primeiras décadas do século XXI, encontrado expressão entre pesquisadores do campo das artes. Práticas performativas não hegemônicas que acionam múltiplas motrizes culturais revelam a localidade de formas naturalizadas como modelos universais, bem como as potências poéticas e políticas das formas periféricas e híbridas. Propomos uma reflexão sobre duas formas de teatralidades performativas amazônicas, a corda dos promesseiros do Círio de Nazaré e o movimento das drags themônias, analisados como táticas de desestabilização do sujeito universal moderno e das ordens classificatórias tradicionais da modernidade no que tange à produção das artes da cena na Amazônia brasileira por meio de um desligamento da estética dominante. Articulamos um conjunto de contribuições conceituais do campo dos estudos decoloniais, dos estudos da performance e da crítica transfeminista para refletir sobre as motrizes culturais diversas acionadas na práticas performativas analisadas, constituindo-se corpos que performam na fronteira, na encruzilhada, recriados, redimensionados e ressignificados, capazes de instaurar estéticas e epistemes decoloniais que desafiam as normatividades hegemônicas e o regime de neoescravização do capitalismo avançado. Palavras-chave: Estéticas decoloniais. Práticas performativas amazônicas. Corda dos promesseiros. Drags themônias.
The competency of Indonesian pharmacy students in handling a self-medication request for a cough: a simulated patient study
Authors: Brata Cecilia , Halim Steven V. , Setiawan Eko , Presley Bobby , Wibowo Yosi I. , Schneider Carl R. 
Published: April 2021

Background: Cough is a common symptom for which people frequently present to community pharmacies. Previous articles from developing countries have shown that the provision of self-medication consultation for cough in community pharmacies were suboptimal, with knowledge deficiency being a contributing factor. However, little is known regarding the ability of pharmacy students in handling self-medication consultations in developing countries.
Objectives: To measure the competency of Indonesian pharmacy students in providing self-medication consultations for patients with chronic cough and to identify factors associated with the provision of appropriate advice.
Method: This study is a cross-sectional study. A simulated patient method using a product and a symptom-based request of chronic cough was used in students from a pharmacy school in Indonesia. The nature and amount of information gathered and advice provided by pharmacy students were noted and audio-recorded. A logistic regression analysis was performed to identify factors associated with the provision of appropriate advice.
Results: The information gathered by participating students was not comprehensive. The most common types of information gathered were related to the nature and duration of the cough. Information relating to accompanying symptoms, medications, and allergies was gathered in less than 60% of the participating students for both product and symptom based scenarios. The appropriate advice of direct medical referral was provided in 54% and 56% of the 183 participating students for the product and symptom-based request scenarios respectively. Asking about symptom duration and prior medical conditions were positively associated with the provision of appropriate advice in the symptom and product based requests respectively.
Conclusion: Student competency in self-medication consultation for chronic cough needs to be improved. Appropriate information-gathering is a predictor of appropriate advice. Further qualitative research identifying factors affecting students’ competence in providing self-medication consultation is required, so that suitable interventions are developed and implemented.
Probe into the Development Potentiality of Chinese Electric Power
Authors: Niu Yitong 
Published: April 2021

<p>After 70 years of development, especially <span style="font-family: 'Times New Roman';">after</span> the 18th National Congress of the CPC, the development of China’s electric power industry has entered a critical stage of transformation, adjustment and transformation. The high quality development of electric power industry is a kind of development that reflects the new development concept, which must be realized through qualitative change, efficiency change and power change. The core of high-quality development in the power industry is to improve efficiency. Reform, open and innovation are the core of efficiency. China’s power industry high-quality development of opportunities and challenges coexist. People’s desire for a better life, continuous improvement of electrification levels, clean use of coal, energy conversion, multi-energy complementarity, market reform of the power system, “Belt and Road Initiative” and electric heating for electric vehicles are among the policies for power and other energy alternatives in China. T<span style="font-family: 'Times New Roman';">here is a</span> great opportunity for industrial development. However, it is also faced with the pressure <span style="font-family: 'Times New Roman';">from the </span>large-scale clean transformation, <span style="font-family: 'Times New Roman';">and </span>the efficiency of the power system is not high enough<span style="font-family: 'Times New Roman';">. T</span>he power cost is not low, and the system mechanism is not perfect. Therefore, we must seize the historical opportunity of energy transformation to establish a high-quality green power system. We will deepen the reform of the electricity market and improve the systems and mechanisms for high-quality development of the power industry<span style="font-family: 'Times New Roman';">, to s</span>olve all kinds of contradictions in the development of electric power industry scientifically.</p>
Hip Arthroplasty with a Preceding Contralateral Pelvic Support Osteotomy: 7- and 21-Year Follow-up
Authors: El-Husseini Timour F. , Mahmoud Ahmed Nageeb , Hosny Gamal A 
Published: April 2021

Case:
This is a case of 27-year-old woman with bilateral hip dysplasia who had been treated with a pelvic support osteotomy (PSO) on 1 side and a contralateral total hip replacement (THR). Good clinical outcomes for both hips were achieved after 21 and 7 years after PSO and THR, respectively. To the best of our knowledge, these 2 different methods have not been previously reported in 1 patient.

Conclusion:
Total hip arthroplasty in presence of contralateral PSO may be offered as a viable treatment option for advanced osteoarthritis to restore hip range of motion and achieve satisfactory clinical results.
Solving a Class of Equilibrium Problems With Equilibrium Constraints*
Authors: Li Peiyu , Ding Ke-Wei 
Published: April 2021

Abstract
An equilibrium problem with equilibrium constraints (EPEC) can be looked on as a generalized Nash equilibrium problem (GNEP) and the mathematical programs with equilibrium constraints (MPEC) whose constraints contain a parametric variational inequality or complementarity system. In this paper, we particularly consider a class of EPEC and solve its normalized stationary points where the multipliers of the leaders on the shared constraints are proportionable. We reformulate this kind of EPEC to a standard MPEC. In addition, we demonstrate the proposed approach on an EPEC model in similar products market.
Folic Acid Attenuated Learning and Memory Impairment via Inhibition of Oxidative Damage and Acetylcholinesterase Activity in Hypothyroid Rats
Authors: Amirahmadi Sabiheh , Hosseini Mahmoud , Ahmadabady Somaieh , Akbarain Mahsa , Abrari Kataneh , Vafaee Farzaneh , Rajabian Arezoo 
Published: April 2021

Abstract
Hypothyroidism has been associated with cognitive decline. Considering the role that has been suggested for folic acid (FA) in cognitive performance, the present study was designed to investigate the effects of FA against hypothyroidism-induced cognitive impairment, oxidative damage and acetylcholinesterase (AChE) activity alterations in propylthiouracil (PTU)-induced hypothyroid rats. In this study, PTU (0.05% in drinking water) and FA (5, 10, and 15 mg/kg, oral gavage) were administered to the rats for a period of 7 weeks. Then, behavioral performance was tested using Morris water maze (MWM) and passive avoidance (PA) tasks. Finally, oxidative stress indicators and AChE activity were assayed in the brain tissues. The impairing effect of hypothyroidism on cognitive performance was markedly alleviated by FA especially at the higher doses. In the MWM test, FA reduced escape latency and travelled distance, compared to the non-treated hypothyroid group. In the PA test, the latency to enter the dark chamber was significantly enhanced by FA as compared to the non-treated hypothyroid group (p < 0.05-p < 0.001). Besides, FA attenuated AChE activity and malondialdehyde level but increased superoxidase dismutase enzyme activity and total thiol content (p < 0.05-p < 0.001). In conclusion, FA could improve learning and memory ability in hypothyroid rats. The observed protective effects may be mediated through regulation of oxidative stress and AChE activity.
Influences of Culture Media, Temperature and Light/Dark Conditions on Growth and Antifungal Activity of Streptomyces spp. Against Botrytis cinerea, in vitro and on Tomato Leaf
Authors: Boukaew Sawai , Yossan Siriporn , Cheirsilp Benjamas , Petlamul Wanida , Prasertsan Poonsuk 
Published: April 2021

Abstract
The influences of culture media, temperature, and light/dark conditions on growth and antifungal activity of the three strains Streptomyces spp. against Botrytis cinerea was studied. Results of in vitro study indicated that the GYM agar and incubated at 28°C exhibited good mycelial growth and a spore mass production of the three strains of Streptomyces spp. On the other hand, the PDA and incubation at 21°C were suitable for the mycelial growth of B. cinerea . Moreover, light/dark conditions had an effect on the growth of the two strains of S. philanthi . The strains RL-1-178 and RM-1-138 of S. philanthi grown in all media and incubation temperatures tested possessed antifungal activity against B. cinerea (100% inhibition) while S. mycarofaciens showed different results on PDA (83% inhibition) and GYM (88% inhibition) with the optimum incubation temperature at 21°C. Then, the antifungal compounds in culture filtrates produced by the three antagonistic strains against B. cinerea were tested on tomato leaf. They showed a significantly higher inhibitory effect on the symptoms of blight disease on tomato leaf compared with the control. The better protection efficacy against B. cinerea on tomato leaf was observed with the culture filtrates of S. philanthi RM-1-138 (82.89% and 0.33 cm 2 lesion areas symptoms). Moreover, the antifungal compounds in the culture filtrate of S. philanthi RM-1-138, identified by GC-MS, were greatly altered relative to concentration components under different temperatures and light/dark conditions tested. Our results clearly demonstrated that the environmental factors have an influence on antifungal activity of the three strains of Streptomyces spp.