bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I Want to, But How?” Defining Counselor Broaching in Core Tenets and Debated Components
Authors: King Kelly M. 
Published: April 2021

Although counselor broaching of cultural identities and structural issues with clients is broadly supported by the counseling profession, how to do so most effectively has been debated. In this article, I identify core tenets, or commonalities, across the broaching literature and critically examine the debates about specific components of broaching practice. I define the term broaching and invite empirical tests of broaching components to begin a process of translating culturally responsive theory into an observable, evidence‐based skill set.A pesar de que en la práctica profesional de la consejería se aprueba mayoritariamente el abordamiento de las identidades culturales y problemas estructurales con los clientes, aún se debate cómo hacerlo de la forma más efectiva. En este artículo, identifico principios fundamentales, o rasgos comunes, en la literatura sobre el abordamiento y examino críticamente los debates sobre componentes específicos de la práctica del abordamiento. Defino el término abordamiento y solicito pruebas empíricas de los componentes del abordamiento para iniciar el proceso de convertir una teoría culturalmente sensible en un conjunto de habilidades observables y basadas en pruebas.
Japan's south foehn on the Toyama Plain: Dynamical or thermodynamical mechanisms?
Authors: Kusaka Hiroyuki , Nishi Akifumi , Kakinuma Ai , Doan Quang‐Van , Onodera Taira , Endo Shuhei 
Published: April 2021

AbstractJapanese society has recently taken a greater interest in foehn warming because it has caused record‐breaking high temperatures and sudden damage to rice crops. This is the first comprehensive climatological study focused on Japan's south foehn, which blows across the Toyama Plain in the Hokuriku region. Climatological analyses, including an objective self‐organizing map and subjective analysis of 198 south foehn cases, revealed that ~68.2% of the foehns occurred while an extratropical cyclone was passing through the Sea of Japan. Approximately 19.7% of the remaining foehns blew while an anticyclone covered Japan. Only 5.1% of all foehns occurred during a typhoon, but very high temperatures occurred when typhoons were approaching. Foehns were observed in all seasons but tended to blow more often in spring, when there are many migratory anticyclones and cyclones. Most of the foehns begin at night and end or pause during the day. This is due to the removal of the nocturnal stable layer and the development of a local daytime pressure gradient on the lee side. The dynamical mechanism provides the primary explanation for Japan's south foehn. Surprisingly, the foehns with precipitation on windward mountains slopes accounted for only ~19.2% of all cases, with ~40.0% being typhoon cases. Most of these are likely of multiple type; a pure thermodynamical type of foehn is a rare occurrence. Numerical simulations and back trajectory analyses for 76 selected foehn cases revealed that the majority of the air parcels originated from the south and passed straight over the Hida Highlands, between two mountain ranges, as a hybrid type of gap and foehn winds.
1‐kHz hybrid femtosecond/picosecond coherent anti‐Stokes Raman scattering thermometry of turbulent combustion in a representative aeronautical test rig
Authors: Scherman Michael , Barros Joanna , Santagata Rosa , Lin Elodie , Nicolas Philippe , Faleni Jean Pierre , Vincent‐Randonnier Axel , Cherubini Pascal , Guichard Florestan , Mohamed Ajmal , Gaffie Daniel , Attal‐Tretout Brigitte , Bresson Alexandre 
Published: April 2021

AbstractThe study of complex reactive flows met in aeronautical engines is an experimental challenge that requires the development of noninvasive and precise measurement techniques. Coherent anti‐Stokes Raman scattering (CARS) is a standard spectroscopic technique used for temperature measurements, which provides unmatched reliability and accuracy at high repetition rate thanks to its recent adaptation to femtosecond temporal regime. This paper reports the first demonstration of hybrid fs/ps‐CARS thermometry in a representative aeronautical combustor (ONERA MICADO test bench, Reynolds number ≈105). Single‐shot N2 CARS spectra have been recorded at 1 kHz, allowing temperature follow up, statistical and frequency (0.1–500 Hz) analysis of CH4/air flame at 0.34‐MPa total pressure. The achieved results demonstrate the ability of the technique to be applied in representative engines conditions and its maturity for semi‐industrial applications.
Changes in soil phosphorus availability and associated microbial properties after chicken farming in Lei bamboo (Phyllostachys praecox) forest ecosystems
Authors: Gai Xu , Li Shaocui , Zhang Xiaoping , Bian Fangyuan , Yang Chuanbao , Zhong Zheke 
Published: April 2021

AbstractBamboo‐chicken farming (BCF) is a popular bamboo complex management model in Southeast Asia. However, the effects of BCF on phosphorus (P) availability and associated soil microbial communities remain poorly understood. In this study, we compared the soil properties, P fractions, phosphatase activities, and bacterial community compositions in the surface soil (0–20 cm) of a typical BCF system under different grazing densities [represented as distances of 5, 15, 25, 35, and > 60 m (control site) from the henhouse, respectively]. We observed that total P (Pt) accumulation was more rapid than that of SOC and TN with increasing grazing density. Labile and moderately labile P dominated soil P accumulation under BCF. Resin‐Pi, NaHCO3‐Pi, and 1 M HCl‐Pi increased by 100–233%, 83–183%, and 414–1,314%, respectively, compared with the control. The ratio of labile and moderately labile organic P to the Pt content decreased significantly with increasing grazing density from 38.54% (control) to 17.65% (5 m site). Soil phosphatase activity increased with increasing grazing density, suggesting that BCF effectively promoted the mineralization of soil Po. Inorganic P (Resin‐Pi, NaHCO3‐Pi, and 1 M HCl‐Pi) was positively correlated with Flavobacterium, Pseudomonas, and Arthrobacter but negatively correlated with Burkholderia; this highlights the different functional bacteria involved in P cycling. We conclude that BCF generally increased soil P availability and supply capacity, and the changes in P forms were closely related to changes in soil bacterial community composition. The highly labile P and low C : P ratio under high grazing density conditions may cause soil nutrient imbalance and P leaching.
Ecological stoichiometry of functional traits in a colonial harmful cyanobacterium
Authors: Duan Zhipeng , Tan Xiao , Paerl Hans W. , Van de Waal Dedmer B. 
Published: April 2021

AbstractTrait‐based approaches provide a mechanistic framework crossing scales from cellular traits to community dynamics, while ecological stoichiometry applies first principles to understand how the balance of energy and elements shape ecological interactions. However, few studies have explicitly linked both frameworks. In this study, we tested the stoichiometric regulation of a number of carbon (C) based (e.g., extracellular polysaccharides and colony formation) and nitrogen (N) containing traits (i.e., chlorophyll a, phycocyanin, and gas vesicle content) in cyanobacteria in laboratory experiments and in the field. We exposed the cosmopolitan colony forming freshwater cyanobacterium Microcystis sp. in batch experiments to light, N and phosphorus (P) limitation, and enhanced CO2 levels, and assessed the regulation of these traits. Cyanobacterial traits followed stoichiometrically predictable patterns, where N containing traits increased with cellular N content, and decreased with increasing C : N ratios. C‐based traits increased with cellular C content and C : N ratios under nutrient, particularly N, limitation. The pattern of colony formation was confirmed with field data from Lake Taihu (China), showing an increase in colony size when N was limiting and N : P ratios were low. These findings demonstrate how an explicit coupling of trait‐based approaches to ecological stoichiometry can support our mechanistic understanding of responses of cyanobacteria toward shifts in resource availability.
On the convergence rates for the three‐dimensional filtered Boussinesq equations
Authors: Bisconti Luca , Catania Davide 
Published: April 2021

AbstractIn this paper we consider a LES model for the approximation of large scales of the 3D Boussinesq equations. We analyze the convergence rate, in appropriate norms, of the unique regular weak solution of the regularized Boussinesq equations towards a weak solution of the original Boussinesq system.
Lycium barbarum Polysaccharide Ameliorates Sjögren's Syndrome in a Murine Model
Authors: Wang Yifan , Xiao Jia , Duan Yuchen , Miao Miao , Huang Bo , Chen Jiali , Cheng Gong , Zhou Xingyu , Jin Yuebo , He Jing , Li Zhanguo , So Kwok‐Fai 
Published: April 2021

ScopeThis study aims to evaluate the therapeutic efficacy and mechanisms of Lycium barbarum polysaccharide (LBP) in primary Sjögren's syndrome (pSS).Methods and resultsNon‐obese diabetic mice (the pSS model) are randomly divided into four groups: Low dose LBP (LBP.L, 5 mg kg−1 d−1), high dose LBP (10 mg
kg−1 d−1), low dose interleukin (IL)‐2 (25
000 IU/d), and control (saline water). Drugs were treated for 12 weeks. LBP.L significantly reduces the salivary gland inflammation compared with the control group (histological score p LBP.L vs Control = 0.019; foci number: p LBP.L vs Control = 0.038). LBP.L also remarkably reduces the effector follicular helper T (Tfh) cells and the CD4+IL‐17A+ helper T (Th17) cells in both spleen and cervical lymph node (cLN) cells. Additionally, the ratios of regulatory T cell (Treg)/Tfh cells and Treg/Th17 cells are substantially increased in mice treated with LBP.L in both spleen and cLNs. LBP also inhibits Th17 and Tfh cells and markedly increases the Treg/Tfh ratio in human peripheral blood mononuclear cells.ConclusionLBP.L inhibits the progression of pSS in mice, associated with modulation of T cell differentiation.
Towards large‐scale steady‐state enhanced nuclear magnetization with in situ detection
Authors: Blanchard John W. , Ripka Barbara , Suslick Benjamin A. , Gelevski Dario , Wu Teng , Münnemann Kerstin , Barskiy Danila A. , Budker Dmitry 
Published: April 2021

AbstractSignal amplification by reversible exchange (SABRE) boosts NMR signals of various nuclei enabling new applications spanning from magnetic resonance imaging to analytical chemistry and fundamental physics. SABRE is especially well positioned for continuous generation of enhanced magnetization on a large scale; however, several challenges need to be addressed for accomplishing this goal. Specifically, SABRE requires (i) a specialized catalyst capable of reversible H2 activation and (ii) physical transfer of the sample from the point of magnetization generation to the point of detection (e.g., a high‐field or a benchtop nuclear magnetic resonance [NMR] spectrometer). Moreover, (iii) continuous parahydrogen bubbling accelerates solvent (e.g., methanol) evaporation, thereby limiting the experimental window to tens of minutes per sample. In this work, we demonstrate a strategy to rapidly generate the best‐to‐date precatalyst (a compound that is chemically modified in the course of the reaction to yield the catalyst) for SABRE, [Ir(IMes)(COD)Cl] (IMes = 1,3‐bis‐[2,4,6‐trimethylphenyl]‐imidazol‐2‐ylidene; COD = cyclooctadiene) via a highly accessible synthesis. Second, we measure hyperpolarized samples using a home‐built zero‐field NMR spectrometer and study the field dependence of hyperpolarization directly in the detection apparatus, eliminating the need to physically move the sample during the experiment. Finally, we prolong the measurement time and reduce evaporation by presaturating parahydrogen with the solvent vapor before bubbling into the sample. These advancements extend opportunities for exploring SABRE hyperpolarization by researchers from various fields and pave the way to producing large quantities of hyperpolarized material for long‐lasting detection of SABRE‐derived nuclear magnetization.
Rheumatology patients’ perceptions of patient activation and the Patient Activation Measure: A qualitative interview study
Authors: Jones Bethan , Hunt Andrew , Hewlett Sarah , Harcourt Diana , Dures Emma 
Published: April 2021

AbstractIntroductionAn important aspect of self‐management is patient activation (the skills, abilities and confidence someone uses to actively manage their health). The dominant method of capturing patient activation is the Patient Activation Measure (PAM) which has been integrated into many aspects of clinical practice in musculoskeletal care. However, limited research has investigated how rheumatology patients understand and perform patient activation, and how closely their perceptions align with the PAM.MethodsSeventeen patients from two rheumatology departments in South West England participated in semi‐structured interviews at two timepoints. They discussed how they actively managed their health and their views on the PAM. Data on activation were analysed using framework analysis and data on the PAM were analysed using content analysis.ResultsParticipants self‐managed with determination, finding ways to make small, sustainable behaviour changes and effectively navigate the healthcare system. They reported the value of knowing what self‐management techniques suited them individually and reported benefitting from positive perceptions of their own health and good social support. Participants noted that the PAM did not always capture the fluctuating nature of their inflammatory arthritis and the collaborative nature of healthcare.ConclusionsPatients' perceptions and experiences of patient activation covered a wide range of skills, behaviours and beliefs. However, these are not always captured by the PAM. Therefore, its use as a clinical tool is best accompanied by dialogue with patients to understand their self‐management.
Effect of roughness on the conductivity of vacuum coated flexible paper electrodes
Authors: Rawal Gaurav , Ghatak Animangsu 
Published: April 2021

AbstractFlexible conducting materials are required for the design and fabrication of a host of applications involving flexible electronic items. A flexible substrate like paper or polymer is generally employed for deposition of metal by a variety of processes. Among many physical properties, the roughness of the substrate is considered an important parameter, although, its exact role on effective conductivity of the coating is not known. Nor any study has been carried out to understand how the three‐dimensional porous structure of the substrate surface affects the microscopic packing of grains that constitute the metal coating. With the objective of elucidating the effect of substrate roughness on the conductivity of paper electrodes, we have used six different commonly available papers for vacuum coating with copper. For a smooth substrate, the grains that constitute the coating appear spherical, however, turns ellipsoidal as the substrate roughness and heterogeneity is increased; ellipsoidal grains result in higher packing efficiency leading to higher conductivity. We have also presented a model to relate the packing efficiency to the asphericity, polydispersity, and skewness of size distribution of grains.
What do we need to know and understand about p53 to improve its clinical value?
Authors: Salomao Norman , Karakostis Konstantinos , Hupp Ted , Vollrath Friz , Vojtesek Borivoj , Fahraeus Robin 
Published: April 2021

AbstractFew proteins are more studied than the p53 tumour suppressor, but what have we learned from these studies and what do we really know about p53 that can benefit clinical practice? The DNA sequence encoding p53 is frequently mutated in cancers but the functional outcomes of single mutations, in respect to loss or gain of different activities, especially in relation to immune evasion, are not clear. This illustrates p53's complexity which even after 40 years keeps providing surprises, but also explains why it has not yet lived up to its potential to benefit cancer treatment. We have reassessed a few key experiments that shaped the p53 field and we take a closer look at the interpretations of these experiments: what they have taught us, the resulting dogmas, and their potential clinical importance. One outcome is a more dynamic view of p53 in terms of its activity, its regulation, and downstream effectors, which will benefit the clinical application of p53 for diagnosis, prognosis, and therapy. Mutations and regulatory factors can have different effects on p53 activity depending on context, important but neglected aspects when interpreting p53 and its pathways in cancers. Even though p53 is undoubtedly unique as a multifunctional hub in different cellular pathways, the concept of a factor taking up different functions within a regulatory pathway during different conditions is not. In this sense, p53 continues to lead the way for a better understanding of the cellular and molecular mechanisms underlying cancer development in vivo. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Real robotic total mesopancreas excision (TMpE) assisted by hanging manoeuver (HM): Standardised technique
Authors: Azagra Juan Santiago , Rosso Edoardo , Pascotto Beniamino , de Blasi Vito , Henrard Alexandre , González González Lucia 
Published: April 2021

AbstractBackgroundPancreaticoduodenectomy (PD) is one of the most demanding interventions for digestive surgeons. R0 resection is a key point for the overall survival and disease‐free survival. Total mesopancreas excision (TMpE) has been described by laparotomy but laparoscopy did not provide good results probably because of the technical difficulties of the approach. We propose a standardised total robotic approach.MethodsIn this step‐by‐step technical description, we propose as example, a case of a 53‐year‐old man with a pancreatic head adenocarcinoma with doubts about the invasion of the mesopancreas surrounding superior mesenteric artery. The mesopancreas hanging manoeuver allows us to perform a TMpE.ResultsThe surgery performed was a robotic artery first pancreaticoduodenectomy with TMpE. The pathological result was pancreatic ductal adenocarcinoma pT2, N1 (1/23), M0, V0, L0, Pn0, R0.ConclusionsRobotic approach is safe, effective and reproductible. Through a standardised technique, it may overcome some of the technical difficulties of laparoscopic PD.
Fault‐tolerant consensus for switched multiagent systems with input saturation
Authors: Yin Yanhui , Wang Fuyong , Liu Zhongxin , Chen Zengqiang 
Published: April 2021

AbstractThis article investigates the fault‐tolerant consensus problem for switched multiagent systems with input saturation. Actuator faults including partial loss of effectiveness, outage, bias, and stuck are all considered in switched general linear systems. By utilizing the adaptive projection algorithm, low gain feedback theory, and average dwell time method, novel saturated consensus protocols are designed for both fixed and switching topologies with local information of neighboring agents. It is proven that the fault‐tolerant consensus problem can be solved with the proposed protocols in both leader‐following case and leaderless case. The innovation of this article lies not only in the fact that actuator faults, switched dynamics, and input saturation are simultaneously considered, but also in the fact that a novel modified low‐and‐high gain feedback approach is introduced to deal with various types of actuator faults. Finally, two numerical examples are given to validate the effectiveness of the theoretical results.
Robotic drilling tests in simulated lunar regolith environment
Authors: Zhang Tao , Zhang Yinliang , Xu Kun , Ding Xilun , Wei Hongyu , Chao Chaoyue , Wang Bin , Wang Bing 
Published: April 2021

AbstractA deep extraterrestrial drilling mission potentially adds a new level of complexity, and it is crucial to understand the associated challenges. To cope with China's Chang'E 5 mission to return subsurface regolith samples from the Moon, a series of laboratory tests were performed to validate the lunar robotic drilling from 2015 to 2018. The tests took place in a simulated thermal‐vacuum regolith environment, a highly relevant lunar analog site. Force and temperature sensors were integrated into a 2‐m class dry auger coring drill to assess the mechanical and thermophysical status of the sampling process. The operation of the entire testing system was automated, covering regolith penetration and data collection and storage. The science team used sensing data to characterize the subsurface geologic strata, assess the conditions of the drilling robot, and direct the sampling strategy. This experiment represents an essential first step in understanding the technology and operational requirements for lunar drilling and sampling mission. Many laboratory tests have helped guide the design and implementation of the highly successful lunar regolith‐sampling task in the Chang'E 5 mission. This paper documents the experimental system design, highlighting some critical design criteria and design tradeoffs. It also discusses the results of laboratory testing and lists some of the key technological lessons learned.
In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2‐b]qinoline Amines Supported with Molecular Docking and MCDM**
Authors: Aydın Ali , Ökten Salih , Erkan Sultan , Bulut Merve , Özcan Evrencan , Tutar Ahmet , Eren Tamer 
Published: April 2021

AbstractThe present study describes mono substituted indeno[1,2‐b]quinolines (3 a–c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1–29.6 μg/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2‐b]quinoline amines (3 a–c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 μg/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103–1.1×105 M−1. The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi‐criteria decision‐making methodology (MCDM) indicated that the mono substituted indeno[1,2‐b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level.