bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENYUSUNAN KAMUS KEDOKTERAN ARAB-INDONESIA DENGAN PENDEKATAN LINGUISTIK KORPUS
Authors: Azzahra Siti Fatimah 
Published: January 2021

Kamus Kedokteran ini merupakan data khusus yang memuat tentang dunia kedokteran (mu’jam takshish) yang secara khusus memuat istilah-istilah yang populer dipakai di ranah kedokteran atau bidang medis. Dalam kamus ini akan memuat istilah-istilah medis yaitu, nama penyakit, nama alat medis, anggota tubuh, serta obat-obatan. Tujuan disusunnya kamus ini yaitu untuk memudahkan para tenaga kerja Indonesia, para medis, serta para pelajar Indonesia, yang bekerja maupun belajar di negara Timur Tengah yang sangat membutuhkan kamus kedokteran Arab – Indonesia. Pemerolehan data diambil dari situs web berita Arab yang menyangkut bidang ranah kedokteran. Penulis memperoleh data dari situs web berita Arab CNN Arabic, BBC Arabic dan Indonesia Alyaoum. Ketiga situs web tersebut Penulis memperoleh data pada bagian صحة (kesehatan), batas yang Penulis gunakan untuk data yaitu, artikel yang terbit pada bulan Oktober 2019 dan bulan November 2019. Penelitian ini menggunakan aplikasi Anchonc pengolah korpus teks Kedokteran. Kamus ini berwajah Arab – Indonesia yang disusun mulai dari huruf hamzah hingga Ya’ yang berdasarkan huruf pertama yang dilafalkan. Dengan menggunakan langkah-langkah yang sesuai dengan sistematika aplikasi tersebut, dapat dihasilkan daftar kata (word list) kamus kedokteran Arab - Indonesia yang memenuhi syarat teknis serta guna menyusun daftar kata. Setelah aplikasi pengolah korpus dipergunakan, selanjutnya penulis menggunakan metode deskriptif yaitu dengan mengungkap secara faktual mekanisme pengolahan bahan berbasis web menjadi format korpus kamus kedokteran Arab - Indonesia serta menyusun daftar kata (word list). Hasil dari penelitian ini dapat ditemukan bahwa dari sepuluh website berita bahasa Arab bisa menghasilkan sekitar empat ratus kosakata bahasa Arab dalam bidang kedokteran.
How decisive is the number of distal arterial anastomoses in coronary bypass surgery?
Authors: Jegaden Olivier , Farhat Fadi , Jegaden Margaux , Hassan Amar , Lapeze Joel , Eker Armand 
Published: January 2021

Abstract
Background. The benefit of arterial revascularization in coronary surgery remains controversial. The incremental value of additional grafts to the left internal thoracic artery (ITA) has been mainly assessed according to the number of arterial grafts, possibly limiting the detection of its actual impact. We analyzed the influence of the number of distal arterial anastomoses (DAA) performed on late mortality in patients having received from one to three arterial grafts.Methods. Retrospective review of 3685 primary isolated coronary artery bypass grafting (CABG) performed from 1989 to 2014 was conducted with a 13-year mean follow-up. One arterial graft (SITA) was used in 969 patients, two arterial grafts, ITA or gastroepiploic artery (GEA), in 1883 patients (BITA: 1644; SITA+GEA: 239), and three arterial grafts in 833 patients (BITA+GEA). Totally, 795 patients (22%) received one DAA, 1142 patients (31%) two, 1337 patients (36%) three, and 411 patients (11%) four or more. A sub-group analysis was done in the 2104 patients with 3-vessel disease who received at least 2 arterial grafts.Results. In this series the early mortality was 1.6 % and it was not influenced by the surgical technique. Late mortality was significantly influenced by age, gender, heart failure, LV ejection fraction, diabetes status, complete revascularization, number of arterial grafts, number of DAA, both ITA, sequential ITA graft, GEA graft. In multivariable analysis with Cox regression model, the number of DAA was the only technical significant independent prognosis factor of late survival (p<0.0001), predominant over both ITA, complete revascularization and number of arterial grafts. The impact of the number of DAA on survival was found discriminant from 1 to 3; after 3 there was no more additional effect. In 3-vessel disease patients who received at least 2 arterial grafts, the number of DAA remained a significant independent prognosis factor of late survival (p<0.0001).Conclusions. The number of distal arterial anastomoses is an independent predictor of long-term survival, predominant over the number of arterial grafts and the completeness of the revascularization; higher the number, better the late survival. It is a strong support of the extensive use of arterial grafting in CABG.
Morphological and molecular characterization of Hoplolaimus pararobustus (Schuurmans Stekhoven and Teunissen, 1938) Sher 1963 with its first report on Zea mays roots in Namibia
Authors: Marais Mariette , van den Berg Esther , Fourie Hendrika , Rashidifard Milad 
Published: January 2021

Abstract
In the summer of 2018, specimens of a Hoplolaimus population were extracted from a maize root sample collected near Stampriet, Namibia. This population was identified as Hoplolaimus pararobustus and is described and illustrated based on its morphological, morphometric, and molecular characteristics. To our knowledge, this is the first report H. pararobustus from maize roots. Females of the population had a mean body and stylet length of 1,100 µm and 36 µm, respectively. Esophagus with three nuclei in three pharyngeal glands. Lateral field reduced, ranging from a very faint line to just breaks in striae. The males were shorter than the females with a mean body length of 925 µm and the stylet slightly shorter, with a mean length of 34 µm. Phylogenetic analyses using partial sequences of 18 S and the expansion fragment D2–D3 of 28 S rDNA genes showed the close relation of this species and H. columbus. This Namibian population of H. pararobustus is the first Hoplolaimus species from Africa to be molecularly characterized.
Anticancer Natural Products with Collateral Sensitivity: A Review
Authors: Qian Jiajun , Cui Jiahua , Li Shaoshun , Chen Jun , Jia Jinping 
Published: January 2021

Background:
Multidrug resistance (MDR) is the resistance of cancer cells against a variety of currently used
antineoplastic agents with diverse structural scaffolds and different anticancer mechanisms. It has been recognized as one
of the major impediments to successful treatment of cancer, leading to the metastasis and relapse of the malignant diseases.

Introduction:
Collateral sensitivity (CS) is the characteristics of certain chemicals to kill the drug-resistant sublines
selectively over the parental cell lines from which the resistant cells were generated. The research and development of new
drug candidates with collateral sensitivity will be an efficient approach to conquer multidrug resistance in cancer. We aims
to provide an update in the discovery of natural products with collateral sensitivity.

Results and Conclusion:
The review focused on the characterized anticancer natural products and
their derivatives with collateral sensitivity, their working mechanisms, and related structure-activity
relationships, emphasizing recently identified CS compounds. According to their structural features,
these MDR-targeting compounds were mainly classified into the following categories: flavonoids,
terpenoids, stilbenes, alkaloids and quinones. The exploration of molecular mechanisms of collateral
sensitivity and structural features of anticancer agents with collateral sensitivity provided an effective
approach for the clinic treatment of MDR in cancer.
Enhanced Analytic Approach for Describing pH Triggered Fast Drug Release Systems
Authors: Elmas Aykut , Akyuz Guliz , Bergal Ayhan , Andac Muberra , Andac Omer 
Published: January 2021

Background::
pH sensitive dendrimers attached to nanocarriers, as one of the drug release
systems, have become quite popular due to their ease of manufacture in experimental conditions
and the ability to generate fast drug release in the targeted area. This kind of fast release behavior
cannot be represented properly in most of the existing kinetic mathematical models. Besides,
these models have either no pH dependence or pH dependence added separately. Therefore,
they remained one dimensional.

Objective::
The aim of this study was to establish the proper analytic equation to describe the fast release of drugs from pH sensitive nanocarrier systems. Then, to combine it with the pH dependent equation for establishing a two-dimensional model for whole system.

Methods::
We used four common kinetic models for the comparison and we fitted them to the release
data. As a result, only Higuchi and Korsmeyer-Peppas models show acceptable suitable results.
None of these models have pH dependence. To get a better description for pH triggered fast
release, we observed the behavior of the slope angle of the release curve. Then we proposed a new
analytic equation by using relation between the slope angle and time.

Result::
By adding a pH dependent equation, we assumed the drug release is “on” or “off” above/below
specific pH value and we modified a step function to get a desired behavior.

Conclusion::
Our new analytic model shows good fitting, not only one-dimensional time dependent release, but also two-dimensional pH dependent release, that provides a useful analytic model to represent release profiles of pH sensitive fast drug release systems.
Antidiabetics Interactions with Herbs: A Compressive Review
Authors: Jirapure Kajal , Undale Vaishali 
Published: January 2021

Abstract:
Diabetes mellitus is a chronic illness with a variety of causes and pathophysiology. For
the management of diabetes, various synthetic antidiabetic drugs are available. Still, people prefer
complementary and alternative therapies as well as traditional herbal home remedies because they
are perceived to be free of side effects and generally recognized as safe due to their natural origin.
Hence, worldwide, the majority of the population is consuming herbs and/or herbal products in
their daily routine. It has been observed that individuals with diabetes also consume herbs/herbal
products either with or without medical supervision. This co-consumption of antidiabetic medications
and herb/herbal products may result in herb-drug interactions, which might be potentially beneficial
or harmful or, in some cases, even fatal. Most of the times, these interactions remain unnoticed
or undiagnosed due to lack of knowledge and awareness about them.
In this review, the authors have summarized some important aspects related to the herb-drug interaction
(HDI), which include methods for prediction and mechanism of HDI (pharmacokinetic and
pharmacodynamic) and also the clinical and experimental literature on herb-drug interactions
(HDI) in the treatment of diabetes. Authors have attempted to categorize the interactions between
oral hypoglycemic agents and various herbs as beneficial or harmful based on the results reported
in the original research work.
Inhibition of Growth of Esophageal Cancer by Alantolactone via Wnt/β- Catenin Signaling
Authors: Wang Zijie , Hu Qing , Chen Huan , Shi Lei , He Min , Liu Hui , Li Ting , Lü Muhan , Deng Mingming , Luo Gang 
Published: January 2021

Background:
Alantolactone (AL) is a natural compound extracted from the roots of Inula Helenium
L, which exerts an anti-tumor effect in a variety of cancer cell lines; however, its effect on esophageal cancer, a
common malignancy with poor prognosis, remains unclear. Therefore, we aim to evaluate the effect of AL on
esophageal cancer and to explore its underlying mechanism.

Objective:
This study aims to determine whether AL has an anti-cancer effect on esophageal cancer cells and to
explore its underlying mechanism.

Methods:
The effect of AL on the proliferation and apoptosis of esophageal cancer cells was detected by MTT
assay, colony formation assay, crystal violet assay, flow cytometry and hoechst apoptosis staining. The wound
healing and Transwell invasion assay were performed to examine the effect of AL on the migration and invasion
of esophageal cancer cells. Luciferase reporter system and Western blot were used to study the anti-tumor
mechanism of AL on esophageal cancer cells. The subcutaneous murine xenograft model was employed to verify
the effects of AL on esophageal cancer cells.

Results:
MTT assay, colony formation assay and crystal violet assay found that AL inhibited the growth of
esophageal cancer cells. Hoechst staining and flow cytometry analysis showed that AL induced apoptosis in
esophageal cancer through mitochondrial pathway. Transwell assay and wound healing assays showed that AL
inhibited the metastasis and invasion of esophageal cancer cells. Wnt/ β-catenin signaling may contribute to the
mechanism of the inhibition. The anti-tumor effect of AL on esophageal cancer cells was validated on murine
xenograft model.

Conclusion:
Our data indicate that AL inhibits proliferation, migration, and invasion of esophageal cancer
cells, and promote apoptosis of esophageal cancer cells through the Wnt/β-catenin signaling pathway.
A Low-Cost, Ear-Contactless Electronic Stethoscope Powered by Raspberry Pi for Auscultation of Patients With COVID-19: Prototype Development and Feasibility Study
Authors: Yang Chuan , Zhang Wei , Pang Zhixuan , Zhang Jing , Zou Deling , Zhang Xinzhong , Guo Sicong , Wan Jiye , Wang Ke , Pang Wenyue 
Published: January 2021

Background
Chest examination by auscultation is essential in patients with COVID-19, especially those with poor respiratory conditions, such as severe pneumonia and respiratory dysfunction, and intensive cases who are intubated and whose breathing is assisted with a ventilator. However, proper auscultation of these patients is difficult when medical workers wear personal protective equipment and when it is necessary to minimize contact with patients.

Objective
The objective of our study was to design and develop a low-cost electronic stethoscope enabling ear-contactless auscultation and digital storage of data for further analysis. The clinical feasibility of our device was assessed in comparison to a standard electronic stethoscope.

Methods
We developed a prototype of the ear-contactless electronic stethoscope, called Auscul Pi, powered by Raspberry Pi and Python. Our device enables real-time capture of auscultation sounds with a microspeaker instead of an earpiece, and it can store data files for later analysis. We assessed the feasibility of using this stethoscope by detecting abnormal heart and respiratory sounds from 8 patients with heart failure or structural heart diseases and from 2 healthy volunteers and by comparing the results with those from a 3M Littmann electronic stethoscope.

Results
We were able to conveniently operate Auscul Pi and precisely record the patients’ auscultation sounds. Auscul Pi showed similar real-time recording and playback performance to the Littmann stethoscope. The phonocardiograms of data obtained with the two stethoscopes were consistent and could be aligned with the cardiac cycles of the corresponding electrocardiograms. Pearson correlation analysis of amplitude data from the two types of phonocardiograms showed that Auscul Pi was correlated with the Littmann stethoscope with coefficients of 0.3245-0.5570 for healthy participants (P<.001) and of 0.3449-0.5138 among 4 patients (P<.001).

Conclusions
Auscul Pi can be used for auscultation in clinical practice by applying real-time ear-contactless playback followed by quantitative analysis. Auscul Pi may allow accurate auscultation when medical workers are wearing protective suits and have difficulties in examining patients with COVID-19.

Trial Registration
ChiCTR.org.cn ChiCTR2000033830; http://www.chictr.org.cn/showproj.aspx?proj=54971.
The Perceived Impact and Usability of a Care Management and Coordination System in Delivering Services to Vulnerable Populations: Mixed Methods Study
Authors: Rizvi Rubina , VanHouten Courtney , Bright Tiffani J , McKillop Mollie M , Alevy Shira , Brotman David , Sands-Lincoln Megan , Snowdon Jane , Robinson Barbie J , Staats Carolyn , Jackson Gretchen P , Kassler William J 
Published: January 2021

Background
People with complex needs, such as those experiencing homelessness, require concurrent, seamless support from multiple social service agencies. Sonoma County, California has one of the nation’s largest homeless populations among largely suburban communities. To support client-centered care, the county deployed a Care Management and Coordination System (CMCS). This system comprised the Watson Care Manager (WCM), a front-end system, and Connect 360, which is an integrated data hub that aggregates information from various systems into a single client record.

Objective
The aim of this study is to evaluate the perceived impact and usability of WCM in delivering services to the homeless population in Sonoma County.

Methods
A mixed methods study was conducted to identify ways in which WCM helps to coordinate care. Interviews, observations, and surveys were conducted, and transcripts and field notes were thematically analyzed and directed by a grounded theory approach. Responses to the Technology Acceptance Model survey were analyzed.

Results
A total of 16 participants were interviewed, including WCM users (n=8) and department leadership members (n=8). In total, 3 interdisciplinary team meetings were observed, and 8 WCM users were surveyed. WCM provided a central shared platform where client-related, up-to-date, comprehensive, and reliable information from participating agencies was consolidated. Factors that facilitated WCM use were users’ enthusiasm regarding the tool functionalities, scalability, and agency collaboration. Constraining factors included the suboptimal awareness of care delivery goals and functionality of the system among the community, sensitivities about data sharing and legal requirements, and constrained funding from government and nongovernment organizations. Overall, users found WCM to be a useful tool that was easy to use and helped to enhance performance.

Conclusions
WCM supports the delivery of care to individuals with complex needs. Integration of data and information in a CMCS can facilitate coordinated care. Future research should examine WCM and similar CMCSs in diverse populations and settings.
Parents’ and Students’ Perceptions of Telepractice Services for Speech-Language Therapy During the COVID-19 Pandemic: Survey Study
Authors: Lam Joseph Hin Yan , Lee Stephen Man Kit , Tong Xiuli 
Published: January 2021

Background
The ongoing COVID-19 pandemic has resulted in the suspension of face-to-face classes and a considerable increase in the use of telepractice services in speech-language pathology. However, little is known about parents’ and students’ satisfaction with telepractice services and their preferences for different service delivery modes. These factors may affect therapy effectiveness and the future adoption of telepractice.

Objective
We evaluated students’ and parents’ perceptions of telepractice efficacy and their preferences for different service delivery modes (ie, on-site practice vs telepractice). We also identified factors that affect parents’ and students’ preferences for different service delivery modes during the COVID-19 pandemic.

Methods
A 19-question survey on telepractice satisfaction and preferences was administered to 41 Hong Kong Chinese students and 85 parents who received telepractice services from school-based speech-language pathologists during the COVID-19 class suspension period. In addition to providing demographic information and data on the implementation of telepractice services, all participants were asked to rate their perceptions of the efficacy of telepractice services and compare on-site practices to telepractice on a 5-point Likert scale (ie, 1=strongly disagree/prefer the use of on-site speech-language therapy services and 5=strongly agree/prefer the use of telepractice services).

Results
Despite the fact that telepractice efficacy was highly rated by parents (95% CI 3.30-3.66) and students (95% CI 3.21-3.76), both groups believed that telepractice was less effective than on-site practices (parents: 95% CI 2.14-2.52; students: 95% CI 2.08-2.65). Moreover, parents preferred on-site practices over telepractice (95% CI 2.04-2.43), whereas students did not prefer one mode of practice over the other (95% CI 2.74-3.41). A significant association between telepractice efficacy and a preference for telepractice services was found only among the students (τ=.43, P<.001), not the parents (τ=.07; P=.44).

Conclusions
Although telepractice is an acceptable alternative service delivery option for providing speech and language therapy services to school-aged individuals, speech-language therapists and parents must play a more proactive role in telepractice services to facilitate effective communication between clinicians and parents.
La enseñanza de la química durante el primer año de la universidad: el estudiante como protagonista de un aprendizaje significativo
Authors: Barraqué Facundo , Sampaolesi Sofía , Briand Laura Estefania , Vetere Virginia 
Published: January 2021

<p>El aprendizaje de la Química durante el primer año de la universidad presenta dificultades propias de la diciplina asociadas a lo abstracto de algunos contenidos y a los diferentes niveles de representación necesarios para su abordaje. Además de la dimensión disciplinar, los ingresantes tienen que habitar una institución que se les presenta con reglas y ordenes simbólicos diferentes a los que están habituados y que demanda más autonomía y responsabilidad. Estas características redundan en un importante grado de deserción y un gran porcentaje de alumnos que no logra acreditar las asignaturas.</p><p>Este contexto nos interpela acerca de las metodologías tradicionales para la enseñanza de la química durante el primer año de la universidad. Así, nos propusimos diseñar un Curso con Estrategias Alternativas para la Enseñanza de la Química (CEAEQ) que, por sus características y su contexto institucional, se trata de una innovación. La propuesta se estructura en el abordaje de la enseñanza desde una perspectiva que pone al estudiante como protagonista y último responsable de su aprendizaje, adoptando los docentes un rol de guías y colaboradores en este proceso. A través de esta propuesta se pretende, por un lado, acompañar a los estudiantes en el aprendizaje de la actitud proactiva frente al estudio necesaria para abordar las carreras de grado. Por otro lado, se busca sentar las bases teóricas de la Química, estimulando a los alumnos a generar un vínculo con el saber que les ayude a comprender problemáticas de la vida cotidiana y a relacionar la química con temas de importancia para nuestra sociedad.</p><p>En el presente trabajo se presenta la propuesta de innovación metodológica, los resultados obtenidos y los desafíos a futuro. El curso fue implementado en dos asignaturas de primer año de carreras de la Facultad de Ciencias Exactas de la Universidad Nacional de La Plata, Argentina. Los resultados encontrados nos alientan a seguir explorando herramientas alternativas a las metodologías tradicionales de enseñanza de esta diciplina. </p>