bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Cases among veterinary practitioners: role played by canine patients in Lagos State
Authors: Shorunke Folajimi O. , Okolocha Emmanuel , Grace S. N. , Usman Aisha , Akano Oluseyi 
Published: August 2021

Abstract
Background COVID-19 was first reported in Nigeria on Feb 27, 2020, as at 9th May 2021 there were 165,382 confirmed cases with 2,065 deaths CFR 1.3%, Lagos accounted for 35% of the cases and 21% of deaths nationwide. Veterinarians play an important role in public health, attending to animal patients and owners, with risk of contracting the virus. We provided epidemiological information on covid-19 among veterinary practitioners and canine contacts in Lagos, during the lockdown and analyzed possible associations.Methods Study carried out in Lagos State, multistage sampling technique used. 5 public and 4 private veterinary facility selected randomly, Clinic registers reviewed and canine blood sample collected for COVID-19 IgG/IgM antibody test. Questionnaires administered to veterinary practitioners in selected facilities, and encouraged to take COVID-19 test. We conducted descriptive statistics using charts, tables and maps, bivariate analysis done, all significant associations at this level was subjected to multivariate analysis.Result Of the 154 canine and 112 veterinary practitioners sampled, 2% of canine and 25.9% of veterinary practitioners returned positive COVID-19 results. Associations were found between returning positive COVID-19 result and residing in Ikeja (OR = 4.12; CI 1.52–11.2, P 0.004) urban settlement (OR = 5.72; CI 1.60-20.44, P 0.003) being a veterinary doctor (OR = 3.64; CI 1.40–9.46, P 0.009) having tertiary education (OR = 3.74; CI 1.04–13.49 P 0.05). Being married was protective (OR = 0.38; CI 0.16–0.93, P 0.04). Only residing in Ikeja was significant at multivariate level.Conclusion In conclusion, 3 canine positive COVID-19 cases where recorded in Ikeja and Ikorodu LGAs, veterinary practitioners had COVID-19 prevalence of 25.9%, associated with residing in Ikeja, urban settlement, being single, being a veterinary doctor, and having tertiary education. No significant relationship found between covid-19 positive veterinary practitioners and canine contacts. We recommended the organization of more IPC training for veterinary practitioners.
Investigating The Effect of Surface Finishing On Performance of Designed Aerostatic Bearing For Its Improved Precision Applications
Authors: Jamwal Karan Singh , Singh Anant Kumar , Arora Kunal , Paswan Sunil Kumar 
Published: August 2021

Abstract
Aerostatic bearing is an ultra-precision component that uses a spindle surrounded by a thin film of air. Due to the high accuracy of aerostatic bearing, the demand for these components is very high in electronic, instrumentation, healthcare, and other manufacturing or processing industries. In the present work, the main focused area is on the experimental determination of the effect of roughness parameter on the performance of the aerostatic journal and thrust bearings. To achieve the aim, the aerostatic bearing is designed based on theoretical analysis. The present design is numerically investigated by simulation of airflow in ANSYS Fluent with computational fluid dynamics module. The results from the simulation are validated by the results generated for pressure distribution in previous researches. After performing the finishing on the bearing and spindle surface, the manufactured components are assembled for analysing the variation in radial and axial loads acting on the spindle with the spindle displacement (1-5 μm) in the direction of the load at supply pressures (3-6 bar) in the clearance of 30 μm. For surface improvement of the air bearing, three different techniques are used namely machining, grinding, and magnetorheological finishing. For each roughness reduction technique, the variation in axial and radial loads acting on the spindle is determined with variation in spindle displacement. The experimental results showed the increase in load capacity due to improvement in the surface finish for journal bearing and thrust bearing at 5 µm displacement in the spindle is found to be 0.68 N for machining to grinding and 2.0 N from grinding to magnetorheological finishing respectively. The results determined for the surface finish parameter reveals the effect of surface roughness on the load-carrying capacity of the aerostatic journal and thrust bearing. The current study on the surface finishing of aerostatic bearing is found effective for the applications such as drives in production machines where good grade of surface finish are the major parameters for improving the overall functional efficiency.
Time Changes Everything: Analysing Temporal Patterns of Evaporative Water Loss
Authors: Žagar Anamarija , Carretero Miguel Angel , de Groot Maarten 
Published: August 2021

Abstract
Higher air temperatures and drier conditions may create stronger water vapour pressure and increase rates of cutaneous water loss, while elevated body temperatures may in turn directly speed up metabolic rates that lead to higher respiratory water loss. Therefore, water budgets are an important organismal trait for understanding their responses to climate change. The most common method of water loss estimation combines respiratory and cutaneous pathways by measuring body weight loss over a defined period of time. Currently, obtained values are often summed or averaged for population or species comparisons. We warn about potential statistical problems using average or summed values of water loss due to emerging temporal patterns. In this study we used a model dataset of lizards and to investigate temporal patterns in water loss datasets. We found that temporal patterns strongly vary across datasets and often deviate from the summed/average profile. Also, the duration of the experiment needs to remain long enough to detect the temporal patterns and produce representative results, while averages at different end-points of the experiment will also vary with temporal patterns. We propose that a simple statistical approach including hour of the experiment as non-linear explanatory variable in GAMM is used to investigate and adequately account for temporal patterns, which will ensure comparability of studies using meta-analyses in the future. Found signal of temporal variation in water loss also suggests that it holds significant biological relevance, potentially mostly connected to behavioural but also physiological adjustments and needs research attention in the future.
Spatial Biomass Production And Seasonal Nutrient Limitation Transitions In A Tributary of The Three Gorges Reservoir, China
Authors: Nwankwegu Amechi Sampson , Li Yiping , Zhang Lei , Huang Yanan , Xie Deti , Norgbey Eyram , Paerl Hans W. 
Published: August 2021

Abstract
The freshwater ecosystem characteristics in terms of nutrient inventory across seasons, spatial variations of chl-a biomass, and the phytoplankton community structure are prudent ecological assessment indices for a bloom management protocol. We evaluated the spatial and seasonal chl-a distribution under different nutrient conditions and phytoplankton community structure in a eutrophic Three Gorges reservoir tributary China. Result showed significant variations in biomass production with the mainstream reaches severely affected. The nutrient addition bioassay demonstrated significant stimulations on growth in both autumn and summer. The nutrient limitation pattern shifted from P in autumn and spring to N limitation during summer. Combined additions of trace metals with N, P, and Si in autumn and Fe alone enrichment in summer and spring showed maximum productivity. The phytoplankton community structure demonstrated strong sensitivities to seasonal variabilities with regime shift from Cyanophyta, dominated by the toxic and hypoxia generating, Microcystis spp in both autumn and summer, the Cryptophyta dominated by the Chroomonas acuta in spring to the Bacilliariophyta dominated by the genera, Cyclotella in winter. This reflected the ability of the Bacilliariophyta to thrive under a low-temperature condition. Combined N&P led to significant growth stimulation in summer while P alone controlled the bulk of the growth in autumn. The study points to the need for extending mitigation steps to the mainstream towards achieving lasting bloom management solution in the impacted tributary.
The Efficacy of Olanzapine-Contained Antiemetic Therapy for Breast Cancer Patients: A Systematic Review and Pooled Analysis
Authors: Xiao Bo-Ya , Lin Guo-He , Liu Zhao-Bo , Tang Yun-Xiang , Wang Bi-Cheng 
Published: August 2021

Abstract
Purpose: As an antipsychotic agent that targets multiple neurotransmitter receptors, olanzapine has been added to antiemetic therapies. However, olanzapine is rarely used in the real-world antiemetic strategies for breast cancer patients who suffered chemotherapy-induced nausea and vomiting. Therefore, in this study, we comprehensively reviewed the antiemetic researches related to olanzapine and pooled analyzed the results from clinical studies to confirm the efficacy of olanzapine in preventing nausea and vomiting in breast cancer.Methods: PubMed, Web of Science, EMBASE, and Cochrane Central databases were searched from inception through April 19, 2021. Both prospective and retrospective studies were eligible. The primary outcomes were complete response (defined as no vomiting and no use of rescue medications) and no nausea rate.Results: Five studies were identified in the systematic review, four of which with 466 breast cancer patients were included in the pooled analysis. In the acute period (0-24 hours), the olanzapine group had significantly higher rates of complete response (71.3% vs 48.1%, odds ratio [OR]: 2.66, 95% confidence interval [CI] 1.39-5.11, p = 0.003) and no nausea (70.0% vs 43.0%, OR: 3.55, 95% CI 1.76-7.18, p = 0.04) than the placebo group. While in the delayed period, the olanzapine group was also superior to the placebo group in terms of the complete response (82.5% vs 63.3%, OR: 3.81, 95% CI 1.58-9.15, p = 0.003) and no nausea (66.3% vs 51.9%, OR: 2.08, 95% CI 1.03-4.21, p = 0.04) rates. During the overall period in prospective studies, the proportions of complete response (50.0% vs 34.2%, OR: 1.93, p = 0.04) and no nausea (51.3% vs 25.3%, OR: 3.40, p = 0.0006) in the olanzapine group were higher than those in the placebo group. Conclusion: Highly emetogenic chemotherapy breast patients could benefit from olanzapine-contained antiemetic therapy. Furthermore, since the cost is low, olanzapine is worth further clinical application and promotion.
Adaptive combination of interventions required to reach population immunity due to stochastic community dynamics and limited vaccination
Authors: Goldenbogen Björn , Adler Stephan , Bodeit Oliver , Wodke Judith , Escalera-Fanjul Ximena , Korman Aviv , Krantz Maria , Bonn Lasse , Torres Rafael Moran , Haffner Johanna , Karnetzki Maxim , Maintz Ivo , Mallis Lisa , Prawitz Hannah , Segelitz Patrick , Seeger Martin , Linding Rune , Klipp Edda 
Published: August 2021

Abstract
Reaching population immunity against COVID-19 is proving difficult even in countries with high vaccination levels. We demonstrate that this in part is due to heterogeneity and stochasticity resulting from community-specific human-human interaction and infection networks. We address this challenge by community-specific simulation of adaptive strategies. Analyzing the predicted effect of vaccination into an ongoing COVID-19 outbreak, we find that adaptive combinations of targeted vaccination and non-pharmaceutical interventions (NPIs) are required to reach population immunity. Importantly, the threshold for population immunity is not a unique number but strategy and community dependent. Furthermore, the dynamics of COVID-19 outbreaks is highly community-specific: in some communities vaccinating highly interactive people diminishes the risk for an infection wave, while vaccinating the elderly reduces fatalities when vaccinations are low due to supply or hesitancy. Similarly, while risk groups should be vaccinated first to minimize fatalities, optimality branching is observed with increasing population immunity. Bimodality emerges as the infection network gains complexity over time, which entails that NPIs generally need to be longer and stricter. Thus, we analyze and quantify the requirement for NPIs dependent on the chosen vaccination strategy. Our simulation platform can process and analyze dynamic COVID-19 epidemiological situations in diverse communities world-wide to predict pathways to population immunity even with limited vaccination.
The Concentrations and Health Risk Assessment of Rare Earth Elements in Tea in China
Authors: Bao Hanbing , Song Yan , Zhou Yujing , Sui Haixia , Yong Ling , Mao Weifeng , Wang Yibana , Bao Huihui , Xiao Xiao , Zhang Lei , Yang Dajing , Jiang Dingguo , Li Ning , Wei Sheng , Liu Zhaoping 
Published: August 2021

Abstract
Background

Rare earth element (REE) have been considered to have potential effects on human health. However, little is known about the health risk of REEs exposure among tea drinkers in China.
Objectives

To characterize the concentration of REEs in different categories of tea and assess the health risk of REEs of tea consumers in China.
Methods

4326 tea samples(including oolong tea, dark tea, black tea, white tea, green tea and flowering tea from markets of 24 provinces, autonomous regions and municipalities in China, were analyzed for sixteen kinds of rare earth elements. Combining the REE concentration data with tea consumption data, derived from the China National Food Consumption Survey 2013–2014, the REE exposure level through tea for adults was estimated. Calculate the hazard quotient, and judge the health risk of the population based on the result value
Results

The average concentrations of rare earth elements in Oolong tea and black tea were the highest (1611.8µg/kg and 1435.2µg/kg), and in green tea and flower tea were the lowest (735.1µg/kg and 564.1µg/kg). The content values of light rare earth elements (LREEs) were dominant in 94.53% of tea samples, cerium (431.5µg/kg) was the most abundant, followed by lanthanum (267.3µg/kg). The average daily dose of REEs in tea intake for Chinese adults was 0.0328µg/kg BW. There are statistical differences in REEs exposure among different genders of tea drinkers(p < 0.001). The average daily intake of REEs in tea was highest in men aged 40–60 (mean: 0.0383µg/kg BW, P95: 0.1421µg/kg BW), but did not exceed the acceptable daily intake (51.5µg/kg BW).
Conclusions

Our study suggested the health risk of REEs exposure from tea is low in tea consumers in China.
TP53 Inhibited AR Signaling Promote Enzalutamide Resistance in LNCaP cell
Authors: Long Xiangyu , Jiang Bo , Liu Jiyan 
Published: August 2021

Abstract
Background: To perform gene screening and search key knockout gene associated with enzalutamide resistance in LNCaP cells. Methods: Genome-scale CRISPR-Cas9 transfection were done to screen genes associated with enzalutamide resistance in LNCaP cells. Bioinformatic analysis of TP53 and AR expression correlated with prostate adenocarcinoma by using TCGA database. Knockout interfering RNA (shRNA) were synthesized in lentivirus and transfected into LNCaP cells by using Lipofectamine 3000. TP53 and AR detection was performed by using conventional molecular biology methods, such as western blot, RT-PCR and flow cytometer et al. Results: 27 high (NES<-1.7, P<0.01) and 26 low (NES>1.7, P<0.01) expressed genes were identified in enzalutamide resistance Cells. TP53 interacted with AR may play an important role in the development of enzalutamide resistance from PPI and RNA-seq data. Data from TCGA support that patient with TP53&AR low expression endured higher pathology stage, Gleason grades, more disease progress, recurrence, positive lymphnotes examination numbers and more abnormal bones scan results. LNCaP cell dealt with enzalutamide or with TP53 knockout showed inhibited cell cycle at G0~G1, increased apoptosis percentage and also inhibited cell proliferation. Conclusions: Current data support that TP53 protein inhabiting AR signaling promote enzalutamide resistance in LNCaP cell.
Twelve-Weeks of Virtual and In-Person Exercise Training Improve Static and Dynamic Balance in Female Cancer Patients
Authors: Aliki Katherine L. , Teranishi-Hashimoto Cheri , Yamada Paulette 
Published: August 2021

Abstract
Background: Balance is important for maintaining activities of daily living and functional independence. Whether balance is improved in cancer patients after fitness training is unclear. The purpose of this study was to determine if 12-weeks of exercise improves balance and posture in female cancer patients. Methods: Thirty-eight female cancer patients were enrolled. Of the 16 patients who completed the program (mean age±SD: 65±10 years), 12 participants were novice and 4 were experienced exercisers. Six-weeks of exercise sessions were provided in-person and the remaining sessions were virtually delivered. The American College of Sports Medicine’s exercise recommendations were followed. Novice exercises received 36, 90-minute exercise sessions (3x/week) and experienced exercisers had 24, 90-minute sessions (2x/week). Posture was measured using the plumb line method and overhead squat test; balance was measured using the unipedal single leg stance and limits of stability (LOS). Body composition, cardiorespiratory fitness, muscular strength, and flexibility were also measured. Two-way repeated measures ANOVAs and Bonferroni’s multiple comparison tests were used to determine significant differences. Results: Balance on the left leg (eyes closed) and LOS with leftward excursion were significantly improved in experienced exercisers (P=0.0029), but not in the novice group (P=0.0013). Qualitative data showed that experienced exercisers had improved static and dynamic postural alignment of the lower body. Conclusions: While cardiorespiratory and muscular fitness significantly improved in the novice group, these patients did not show balance and postural improvements. Only the experienced exercisers had significant improvements in static and dynamic balance and lower body posture.
Research on Eco-geological Environment Carrying Capacity for Pingwu County after Wenchuan Earthquake Based on Modified AHP
Authors: wang pu , Liu Yimin 
Published: August 2021

Abstract
Many counties in southwestern China are devastated by the Wenchuan earthquake, and the earthquake also induced lots of geological hazards. So evaluation of the eco-geological environment in the disaster area is essential for county restoration and ecological remediation. This research accounts for Pingwu County, which is 89 km to the epicenter of the Wenchuan earthquake, as a study area to evaluate eco-geological environment carrying capacity. Firstly, three evaluation index layers are built to the eco-geological environment carrying capacity model after the earthquake, including geological environment, ecological environment, and social environment. And then, the evolutionary algorithm(EA) is used to modify Analytic Hierarchy Process(AHP). Through optimizing consistency ratio of AHP, the best consistent evaluation matrix can be obtained. Finally, We calculate the eco-geological environment carrying capacity of Pingwu by the best consistent evaluation matrix, and obtain hierarchical map of the eco-geological environment carrying capacity through grid rasterization. The results show that current eco-geological environment carrying capacity in Pingwu county mainly contains two states, equilibrium and surplus. According to the hierarchical map, this study suggests optimizing the construction of the central area in Pingwu, controlling the scale of regional construction, and maintaining the original ecological species in the natural protection area.
Cancer Risk Behaviors, Cancer Beliefs and Health Information Seeking Among Under-Represented Populations in San Francisco: Differences by Sexual Orientation and Gender Identity
Authors: Santiago-Rodríguez Eduardo J. , Rivadeneira Natalie A. , DeVost Michelle A. , Sarkar Urmimala , Hiatt Robert A. 
Published: August 2021

Abstract
Background

Compared to the general population, sexual and gender minorities (SGM) are at increased risk of some types of cancer, in part due to engagement in high-risk behaviors and lack of adequate preventive care. Understanding how SGM perceive cancer risk and their practices and preferences for accessing health information is key for improving the preventive and healthcare services they receive.
Methods

In this cross-sectional study we analyzed data from the San Francisco Health Information National Trends Survey. SGM were identified by self-report. Differences in cancer risk factors and cancer beliefs as well as health information seeking behaviors and preferences were evaluated by sexual orientation and gender identity (SOGI) using multivariable logistic regression models.
Results

Out of 1027 participants, 130 (13%) reported being SGM. In multivariable models adjusting for age, sex at birth, education and race/ethnicity, current smoking was more common in SGM than non-SGM respondents (OR = 1.62, 95% CI = 1.03, 2.54). No differences in health information seeking behaviors, preferences and cancer beliefs were observed by SGM status. However, SGM reported significantly higher odds of feeling frustrated during the most recent health information search (OR = 1.71, 95% CI = 1.14, 2.56).
Conclusions

In this diverse urban population, SGM were more likely to be current smokers. No differences in preferences for accessing and exchanging health information were reported by SGM status. The drivers of increased feelings of frustration while seeking health information and its implications for SGM health and care merit further evaluation. Also, tobacco cessation interventions should be promoted in this community.
Effectiveness of Inner Traction Facilitated Endoscopic Submucosal Dissection using Rubber Band and Clips for Colorectal Neoplasms: A Propensity Score-matched Study
Authors: Liu Guanyi , Guo Xinyue , Cai Yunlong , Rong Long , Nian Weidong , Zhang Jixin 
Published: August 2021

Abstract
Background Colorectal endoscopic submucosal dissection (ESD) is a technically demanding but effective treatment for superficial neoplasms. We conducted a study to compare the effectiveness and safety of inner traction facilitated ESD using rubber band and clip (RAC-ESD) with conventional ESD.Methods We retrospectively evaluated 622 consecutive patients underwent colorectal ESD between January 2016 and December 2019. To overcome selection bias, we used propensity score matching (1:4) between RAC-ESD and conventional ESD. The frequency of en bloc resections, R0 resections, curative resections, procedure speed and complications were evaluated.Results After propensity score matching, 35 patients were included in RAC-ESD group and 140 were included in conventional ESD group. RAC-ESD resulted in a significant increase in resection speed (0.14 vs. 0.09 cm2/min; P=0.003). There were no significant differences in en bloc, R0 and curative resection rates between two groups. In subgroup analysis, the resection speed of RAC-ESD was significantly higher than conventional ESD when the lesions were equal to or larger than 2cm, macroscopically presenting as lateral spreading tumor, and located in transverse colon to ascending colon.Conclusions RAC-ESD is safe and effective in treating colorectal neoplasms, especially in lesions presenting particular difficulty.