bluuebunny/crossref_metadata_2025_split huggingface dataset:
A unifying perspective of the ultrafast photo-dynamics of Orange Carotenoid Protein from Synechocystis: peril of high-power excitation, existence of different S* states and influence of tagging
Authors: Niziński Stanisław , Wilson Adjéle , Uriarte Lucas M. , Ruckebusch Cyril , Andreeva Elena A. , Schlichting Ilme , Colletier Jacques-Philippe , Kirilovsky Diana , Burdzinski Gotard , Sliwa Michel 
Published: December 2021

ABSTRACTA substantial number of Orange Carotenoid Protein (OCP) studies have aimed to describe the evolution of singlet excited states leading to the formation of photo-activated form, OCPR. The most recent one suggests that three picosecond-lived excited states are formed after the sub-100 fs decay of the initial S2 state. The S* state which has the longest reported lifetime of a few to tens of picoseconds is considered to be the precursor of the first red photoproduct P1. Here, we report the ultrafast photo-dynamics of the OCP from Synechocystis PCC 6803, carried out using Visible-NIR femtosecond time-resolved absorption spectroscopy as a function of the excitation pulse power and wavelength. We found that a carotenoid radical cation can form even at relatively low excitation power, obscuring the determination of photo-activation yields for P1. Moreover, the comparison of green (540 nm) and blue (470 nm) excitations revealed the existence of an hitherto uncharacterized excited state, denoted as S∼, living a few tens of picoseconds and formed only upon 470 nm excitation. Since neither the P1 quantum yield nor the photo-activation speed over hundreds of seconds vary under green and blue continuous irradiation, this S∼ species is unlikely to be involved in the photo-activation mechanism leading to OCPR. We also addressed the effect of His-tagging at the N- or C-termini on excited state photo-physical properties. Differences in spectral signatures and lifetimes of the different excited states were observed, at variance with the usual assumption that His-tagging hardly influences protein dynamics and function. Altogether our results advocate for careful consideration of the excitation power and His-tag position when comparing the photo-activation of different OCP variants, and beg to revisit the notion that S* is the precursor of photoactivated OCPR.TOC
In vitro and in vivo NIR Fluorescence Lifetime Imaging with a time-gated SPAD camera
Authors: Smith Jason T. , Rudkouskaya Alena , Gao Shan , Gupta Juhi M. , Ulku Arin , Bruschini Claudio , Charbon Edoardo , Weiss Shimon , Barroso Margarida , Intes Xavier , Michalet Xavier 
Published: December 2021

AbstractNear-infrared (NIR) fluorescence lifetime imaging (FLI) provides a unique contrast mechanism to monitor biological parameters and molecular events in vivo. Single-photon avalanche photodiode (SPAD) cameras have been recently demonstrated in FLI microscopy (FLIM) applications, but their suitability for in vivo macroscopic FLI (MFLI) in deep tissues remains to be demonstrated. Herein, we report in vivo NIR MFLI measurement with SwissSPAD2, a large time-gated SPAD camera. We first benchmark its performance in well-controlled in vitro experiments, ranging from monitoring environmental effects on fluorescence lifetime, to quantifying Förster Resonant Energy Transfer (FRET) between dyes. Next, we use it for in vivo studies of target-drug engagement in live and intact tumor xenografts using FRET. Information obtained with SwissSPAD2 was successfully compared to that obtained with a gated-ICCD camera, using two different approaches. Our results demonstrate that SPAD cameras offer a powerful technology for in vivo preclinical applications in the NIR window.
Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
Authors: Waheed Qaiser , Zhou Huimin , Ruoff Peter 
Published: December 2021

AbstractHomeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control, in the analysis and design of homeostatic networks. Several reaction kinetic mechanisms have been discovered which lead to integral control. In two of them integral control is achieved, either by the removal of a single control species E by zero-order kinetics (”single-E controllers”), or by the removal of two control species by second-order kinetics (”antithetic or dual-E control”). In this paper we show results when the control species E1 and E2 in antithetic control are removed enzymatically by ping-pong or ternary-complex mechanisms. Our findings show that enzyme-catalyzed dual-E controllers can work in two control modes. In one mode, one of the two control species is active, but requires zero-order kinetics in its removal. In the other mode, both controller species are active and both are removed enzymatically. Conditions for the two control modes are put forward and biochemical examples with the structure of enzyme-catalyzed dual-E controllers are discussed.
dbGSRV: a manually curated database of genetic susceptibility to respiratory virus
Authors: Li Ping , Zhang Yan , Shen Wenlong , Shi Shu , Zhao Zhihu 
Published: December 2021

AbstractHuman genetics has been proposed to play an essential role in inter-individual differences in respiratory virus infection occurrence and outcomes. To systematically understand human genetic contributions to respiratory virus infection, we developed the database dbGSRV, a manually curated database that integrated the host genetic susceptibility and severity studies of respiratory viruses scattered over literatures in PubMed. At present, dbGSRV contains 1932 records of genetic association studies relating 1010 unique variants and seven respiratory viruses, manually curated from 168 published articles. Users can access the records by quick searching, batch searching, advanced searching and browsing. Reference information, infection status, population information, mutation information and disease relationship are provided for each record, as well as hyper links to public databases in convenient of users accessing more information. In addition, a visual overview of the topological network relationship between respiratory viruses and associated genes is provided. Therefore, dbGSRV offers a promising avenue to facilitate researchers to dissect human factors in respiratory virus infection, define novel drug targets, conduct risk stratification of population and develop personalized medicine approaches.Database URL: http://www.ehbio.com/dbGSRV/front/
CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells
Authors: Bommi-Reddy Archana , Park-Chouinard Sungmi , Mayhew David N. , Terzo Esteban , Hingway Aparna , Steinbaugh Michael J. , Wilson Jonathan E. , Sims Robert J. , Conery Andrew R. 
Published: December 2021

ABSTRACTTherapeutic targeting of the estrogen receptor (ER) is a clinically validated approach for estrogen receptor positive breast cancer (ER+ BC), but sustained response is limited by acquired resistance. Targeting the transcriptional coactivators required for estrogen receptor activity represents an alternative approach that is not subject to the same limitations as targeting estrogen receptor itself. In this report we demonstrate that the acetyltransferase activity of coactivator paralogs CREBBP/EP300 represents a promising therapeutic target in ER+ BC. Using the potent and selective inhibitor CPI-1612, we show that CREBBP/EP300 acetyltransferase inhibition potently suppresses in vitro and in vivo growth of breast cancer cell line models and acts in a manner orthogonal to directly targeting ER. CREBBP/EP300 acetyltransferase inhibition suppresses ER-dependent transcription by targeting lineage-specific enhancers defined by the pioneer transcription factor FOXA1. These results validate CREBBP/EP300 acetyltransferase activity as a viable target for clinical development in ER+ breast cancer.
Contrasting effects of accumulation and tolerance characteristics in Arabidopsis thaliana under Cr(III) and Cr(VI) stress
Authors: Han Yonghong , Ding Guotao , Sun Peng , Li Giuiying , Li Weihao 
Published: December 2021

AbstractIn this study, for the first time we investigated Cr(III) and Cr(VI) stress-induced physiological and biochemical responses in Arabidopsis thaliana. The capacity of A. thalian to accumulate Cr is closely related to the valence of chromium. Cr(VI) was more toxic than Cr(III) as indicated by chromium accumulation and growth inhibition. When the concentration of chromium is greater than 200μM, the root length and biomass of A. thaliana are reduced. But interestingly, Cr(III) at 200μM increased the root length and biomass of A. thaliana compared to the control. The transmission electron microscope shows that Cr(VI) can cause the chloroplasts damaged and the chlorophyll reduced more than Cr(III). The chloroplasts were filled the starch grains. An increase of lipid peroxidation in A. thaliana roots caused by Cr was measured, and this effect increases as the increasing Cr. It indicated that A. thaliana suffers from Cr-induced oxidative stress which resulted cell death in roots. To fight against oxidative stress, Ascorbate peroxidase and Glutathione reductase were activated by Cr in antioxidant defense. The inhibition of growth, the accumulation of chromium, the responses of antioxidant systems, and the ultra-morphological changes indicate that Cr(VI) was more toxic than Cr(III).
Determinants of trade credit financing: a dynamic analysis comparing agri-food cooperatives and non-cooperatives
Authors: Martínez-Victoria MCarmen , Maté-Sanchez-Val Mariluz 
Published: December 2021

PurposeThe particular characteristics of agri-food cooperatives reduce their ability to access external financial resources. The purpose of this paper is to explore the factors influencing the agri-food cooperatives' trade credit operations by measuring their accounts receivable and comparing the results with agri-food investor-owned firms (IOFs).Design/methodology/approachThe authors apply a partial adjustment model (PAM) estimated using a dynamic panel model with a two-step general method of moments (GMM) estimator to a sample of 11,930 Spanish agri-food cooperatives and IOFs for the period 2011–2018.FindingsThe study concludes that cooperatives and IOFs have an accounts receivable target, which they attempt to achieve rapidly. Cooperatives tend to behave as IOFs do, but they present lower adjustment coefficients. This difference seems to be explained by the unique characteristics of cooperatives which set different economic and social goals, not just profit maximization as IOFs. The findings show differences between the financial and commercial purposes of the cooperatives and IOFs as a result of their internal management policies. Larger cooperatives with access to external financial sources, positive cash flows and operational necessities will grant trade credit.Originality/valueThis study gives interesting implications for cooperative managers and policymakers to help them to understand the strategies behind trade credit policies. Previous empirical studies on the agri-food sector are scarce and focus on IOFs without considering the role of trade credit in European cooperatives.
Searching memories of pleasures in local cuisine: how nostalgia and hedonic values affect tourists' behavior at hot spring destinations?
Authors: Chang Janet , Lin Sean Hsin-Hung , Wu Li-Sheng 
Published: December 2021

PurposeHistorically, hot springs have been regarded as hedonic and foodie destinations, yet the antecedents that affect tourists' intentions for local cuisine in hot springs remain unexplored. The present study aims to address this knowledge gap by considering the role of nostalgia and hedonic values in tourist food consumption.Design/methodology/approachData were collected from 315 domestic tourists by intercept surveys conducted in the Beitou Hot Spring, Taiwan. Covariance-based structural equation modeling (SEM) and bootstrapping were used to test the hypotheses as well as mediating effects.FindingsNostalgia positively influences hedonic values, which affect tourists' intentions for local food consumption. Unexpectedly, nostalgia does not directly influence tourists' preferences due to complete mediation through hedonic values.Research limitations/implicationsGiven a growing number of young consumers visiting hot springs, hedonic experience is essential and more effective for pulling visitors and stimulating local food consumption than nostalgia vibes are. Cross-cultural samples and qualitative research are suggested for future studies.Originality/valueThe study demonstrates different levels of nostalgia in different ages. It highlights the mediating role of hedonic values between nostalgia and tourists' intentions for local cuisine in the hot spring destinations, which has been overlooked in previous studies. Originality is also established by simultaneously investigating hedonic values and behavioral intentions within the context of food tourism.
Quality perception throughout the table egg supply chain
Authors: Mitrovic Marija , Tomasevic Igor , Djekic Ilija 
Published: December 2021

Purpose:This research shows how the perception of quality differs through the table egg chain and highlights the main quality characteristics for each studied chain participant (farm, retail, consumer).Design/methodology/approach:Observing the change in perception starts from the farm, through retail to the end consumer using the customer–supplier interaction, while looking back from the consumer to the farm, the application of the quality function deployment (QFD) was used. The study included 30 farms, 50 retail stores, 1,000 customers and 300 households.Findings:The farm–retail comparison highlights the type of production as the dominant factor affecting egg quality for both of these participants, followed by hen diet and the type of laying hen hybrid from the farmer's point of view, while retail focuses on packaging and egg damage. Egg quality aspects from the retail–household perspective emphasize the shell appearance and the origin of the eggs, while shelf life and egg class are equally important characteristics for both participants. The application of the QFD throughout the entire egg chain emphasizes quality vs price as the most important characteristic.Originality/value:This study could serve to food policy makers as an introduction to further research and production orientation in relation to the set of quality requirements associated with the egg supply chain.
A global perspective of the role of domestic economic, financial and political risks in inbound tourism
Authors: Athari Seyed Alireza , Alola Uju Violet , Alola Andrew Adewale 
Published: December 2021

PurposeIn this study, as part of an attempt to foster sustainable development, the aim is directed at understanding the perspectives of domestic economic, financial and political risks in tourism development. On the other hand, the role of other agents of sustainable development: innovation, infrastructure, health and primary education and global crisis in tourism development, was illustrated.Design/methodology/approachTo achieve this objective, the current study explored the (system) SYS-Generalized Method of Moments (GMM) technique for a panel of selected 73 economies over the period 2006–2017. This GMM approached is not undertaken without first establishing the stationarity (a preliminary test) of the employed dataset by utilizing the relevant unit root techniques.FindingsFirst, the study found that minimizing risks from economic, financial and political aspects is significant and vital to the attractiveness of the tourism destinations and the eventual development of the tourism sector. Second, the study presents innovation or technological readiness and health and primary education as agents of sustainable development through the growth of international tourism arrivals while global crisis is significantly detrimental to tourism inflow.Originality/valueOverall, the study presents the contribution of tourism as a pathway to sustainable development from unique dimensions. Investigating a large panel (of 73 countries) is a unique approach. In addition, considering the economic vulnerability of the panel countries from the aspects of risk arising from economic, financial and political aspects is another interesting dimension to the novelty of the study. Thus, this study offers relevant policies for tourism stakeholders.
Influence of the taper on the fretting wear of the femoral stem-femoral head taper junction in total hip prosthesis
Authors: Capitanu Lucian , Badita Liliana-Laura , Tiganesteanu Constantin , Florescu Virgil 
Published: December 2021

Purpose
The purpose of this paper is to study the roughness effect on the fixation of taper junction components and surfaces wear in terms of taper surface design. The roughness of the femoral heads’ taper and of the femoral stems’ trunnions can influence the fretting wear of the taper junction.

Design/methodology/approach
It was analysed whether a microgrooved taper surface of the femoral stem trunnion improves the fixation and reduces the wear rate at the taper junction of the hip prosthesis. Two models have studied: a femoral head with a smooth tapered surface combined with a microgrooved stem trunnion and a femoral head with a smooth tapered surface combined with a trunnion that had a smooth surface of the tapered. To compare the wear evolution between these two models, a computerised finite element model of the wear was used.

Findings
The results obtained after analysis carried out during millions of loading cycles showed that the depth of the linear wear and the total material loss were higher for the femoral heads joined with microgrooved trunnions. The main conclusion of this paper is that the smooth surfaces of the taper and of the trunnions will ensure a better fixation at the taper junction, and therefore, will reduce the volumetric wear rates.

Originality/value
A higher fixation of the taper junction will reduce the total hip prosthesis failure and, finally, it will improve the quality and durability of modular hip prostheses.
The role of key online reviews in affecting online hotel booking: an empirical investigation
Authors: Zhang Dong , Wu Pengkun , Wu Chong 
Published: December 2021

Purpose The importance of online reviews on online hotel booking has been widely acknowledged. However, not all online reviews affect consumers equally. Compared with common online reviews, key online reviews (KORs) have a greater influence on consumers' decisions and online hotel booking. This study takes the first step to investigate the factors affecting the identification of KORs and the role of KORs in online hotel booking.Design/methodology/approach To test the research hypotheses, this study develops a crawler to obtain 551,600 online reviews of 650 hotels in ten representative large cities in China. This study first uses a binary logistic regression to identify KORs by combining review content quality and reviewer characteristics and then uses a log-regression model to investigate the role of KORs in online hotel booking.Findings This study mined the factors affecting the identification of KORs by analyzing review contents and reviewer characteristics. Our results revealed that KORs play a mediating role in the effects of review content and reviewer characteristics on online hotel booking.Originality/value This study focuses on KORs, which have received limited attention in research but are important to practitioners. Specifically, this study investigates the antecedents and consequences of KORs. Our results enable hotel managers to manage online reviews effectively, particularly KORs.
Restorative measures to diminish the covid-19 pandemic effects through circular economy enablers for sustainable and resilient supply chain
Authors: Agarwal Somesh , Tyagi Mohit , Garg Rajiv Kumar 
Published: December 2021

Purpose
The catastrophic state of the COVID-19 pandemic outbreak has seized off all the operations along with the globe. It has not only distressed the socio-economic structure of the world but also mounted enormous pressure on the governmental bodies to save the lives of the people. Despite this, severe impacts of the same have been observed on the small and medium manufacturing enterprises (SMME) practices, resulting in the economic downturn. The purpose of this study is to facilitate the SMME’s with circular economy (CE) practices to overcome the negative impacts of the COVID-19 outbreak on their supply chain (SC) operations.

Design/methodology/approach
The presented work identified seven critical impacts as criteria of the novel COVID-19 pandemic on the Indian SMME and seeks to identify the relief measures in the CE paradigm by identifying 13 prominent enablers to CE as alternatives. Experts’ opinions have been engaged to detect CE enablers’ proficiency to overpower the pandemic impact through a questionnaire-based survey. The obtained data have been clustered and analyzed through a hybrid approach of entropy weight method and grey relational analysis to find an organized ranking of the enablers.

Findings
Current work spotlights the SMME’s losses due to SC disruptions and declined consumption patterns. The waste augmentation during the pandemic era has also been grouped in this study, primarily associating with the SC’s waste generation. The result of the performed analysis shows that the CE enabler “waste reduction and its transformation into a resource (E1)” have achieved the highest rank among all the considered enablers, governing a higher demand toward reusing waste for better handling the post COVID era state of affairs.

Originality/value
The presented study aimed to suppress the pandemic impact and generate anticipation of the CE concept, which might help the managers and policymakers identify its urgent need to achieve a stable and resilient SC system in a post COVID period. Presented work is peculiar, aiming to accelerate the CE adaption with green material usage in the industrial sector to suppress the present miserable condition and to achieve industrial and social sustainability for a better-foreseen future.
How does dataveillance drive consumer online payment resistance?
Authors: Shankar Amit , Yadav Rambalak , Behl Abhishek , Gupta Manish 
Published: December 2021

Purpose
This study aims to examine the effect of dataveillance on resistance towards online payment. Using a moderated-mediation framework, the study also investigates the mediating effects of perceived privacy and security concerns and how these mediating effects are moderated by corporate credibility, consumer scepticism and consumer empowerment.

Design/methodology/approach
A scenario-based experimental design was performed to examine the proposed hypotheses. Analysis of covariance and PROCESS macro were used to examine the hypotheses by analysing 312 collected responses.

Findings
The results indicated the dataveillance positively affects consumer resistance towards online payment. The results also suggested that corporate credibility and consumer scepticism significantly moderates the association between dataveillance and resistance towards online payment.

Practical implications
The findings of this study will help online retailers to reduce consumers’ perceived privacy and security concerns, thereby reducing consumers’ resistance towards online payment.

Originality/value
Theoretically, the study contributes to privacy, consumer behaviour, online payment and cognitive-motivational-relational theory literature.