bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PREDIKSI TINGKAT KELULUSAN MAHASISWA UNIVERSITAS WIRALODRA INDRAMAYU MENGGUNAKAN METODE FUZZY TSUKAMOTO
Authors: Dandi Muhamad , Fernando Kinky , Hidayat Taufik 
Published: March 2021

Universitas Wiralodra merupakan Universitas swasta pertama di Indramayu, terletak di Kota Indramayu, Jawa Barat. Seiring dengan perjalanannya, Universitas Wiralodra terus berbenah untuk meningkatkan kapasitasnya, melalui peningkatan kualitas Sumber Daya Manusia (SDM) Dosen, Manajemen, kegiatan mahasiswa, penelitian dan publikasi, serta perbaikan sarana dan prasarana kampus. Kelulusan merupakan suatu hal yang dapat diharapkan oleh setiap mahasiswa, yang nantinya akan menjadi bekal seseorang mahasiswa dalam menempuh jenjang selanjutnya. Permasalahannya apakah mahasiswa Universitas Wiralodra bisa lulus dengan maksimal atau tidak. Dalam penelitian lebih memfokuskan bagaimana implementasi teori logika fuzzy dalam memprediksi tingkat kelulusan mahasiswa Universitas Wiralodra. Teori logika fuzzy ini digunakan karena mudah untuk dimengerti. Pada Penelitian ini menggunakan teori fuzzy tsukamoto dengan 2 variabel input yang terdiri dari jumlah penerimaan wisuda dan jumlah mahasiswa yang akan menhasilkan status jumlah mahasiswa yang lulus. Tujuan dari penelitian ini yaitu untuk memprediksi jumlah mahasiswa yang lulus dalam setiap tahunnya di Universitas Wiralodra Indramayu. Pada penelitian selanjutnya agar keputusan dalam menganalisis kondisi tingkat kelulusan mahasiswa agar digabungkan metode fuzzy tsukamoto dan markov chain agar masalah yang terjadi dalam memprediksi tingkat kelulusan mahasiswa dapat lebih akurat.
Formation of computational thinking skills in the development of computer games for educational purposes
Authors:   Vyatka State University, Soboleva Elena V. , Kirillova Ekaterina P. ,   Vyatka State University, Lomakin Denis E. ,   Orel State University named after I.S. Turgenev, Gribkov Dmitry N. ,   Orel State Institute of Culture
Published: March 2021

The problem and the aim of the study. The problem, to be solved by the study, is proper to the need to expand the goals of the education system, to update tools and methods based on digital technologies, that promote the activation of a sequence of images from a person's memory, formulate a problem, and compose an effective solution algorithm. For the formation of the relevant skills that determine the essence of special computational thinking, the authors propose to include in the educational and cognitive activities of students the practice of developing game educational spaces using digital gamification resources. Research methods. To obtain theoretical generalizations was used the analysis of scientific works on the problem of defining the phenomenon of "computational thinking", the apply of digital resources of gamification in teaching. The HTML 5 language as a software implementation tool was used. The study involved 26 bachelors of the Institute of Mathematics, Informatics and Physics in the direction 01.03.02 Applied Mathematics and Informatics and 13 students in the direction 44.04.01 Pedagogical education (master's level) of Vyatka State University. The experiment used the Student's t-test. Results. The authors clarify the essence of the concept of "computational thinking", includes a system of actions for activating patterns from human memory, connections between them; problem statement into account the uncertainty of the future; drawing up an effective solution algorithm using digital technology tools. The authors described directions of educational and cognitive activities, based on the principles of gamification: obtaining relevant information on advanced technological developments; problem statement and modeling; creation of your own software product. The effectiveness of the proposed approach was assessed and statistically significant differences in qualitative changes in temp> tcrit were revealed at α = 0.05 (8,2> 2,06). In conclusion the authors generalized the conditions that influence the formation of computational thinking: obtaining relevant scientific and theoretical facts, patterns, information on innovative methods and tools; reasoned choice, effective implementation at a high technical level; analysis of the result and its practical application.
Impactos ambientales generados por la mina de arcilla Wajira S.A.S., en Manaure- La Guajira
Authors: Cotes Daniel , Alvarado Laura , Hoyos Edrianis , Molina Marcela , Mosquera Dayeli 
Published: March 2021

Las problemáticas ambientales más frecuentes en las minas de arcilla en el departamento de la Guajira se ven generalizadas por: la afectación y modificación morfológica del suelo, atrasando la Genesis del suelo, la tala de árboles, la perdida de la capa vegetal, erosión del suelo, perdida de hábitat en términos de fauna y problemas futuros en términos de O2ya conociendo que son estas plantas las que disminuyen el CO2 de la atmosfera para convertirlo en O2. La finalidad de este estudio es identificar los impactos ambientales generados por la mina de arcilla WAJIRA S.A.S., en Manaure- la Guajira. Este estudio está enmarcado en el tipo de investigación descriptivo con enfoque cualitativo, ya que a través de valoraciones subjetivas se realizará un diagnóstico de los impactos ambientales que genera la mina de arcilla Wajira S.A.S. Se concluye que la mayoría de los componentes tal como el agua, suelo, flora (pérdida de biodiversidad y extinción de las especies endémicas), fauna en la emigración de especies y disminución de las especies endémicas, estudiados para las fases de construcción y operación generan impacto moderado, es decir, requieren medidas bien elaboradas, la recuperación de las condiciones iniciales ameritan cierto tiempo y se precisan prácticas de manejo simples.
Living Well with Kidney Disease by Patient and Care-Partner Empowerment: Kidney Health for Everyone Everywhere
Authors: Kalantar-Zadeh Kamyar , Li Philip , Tantisattamo Ekamol , Kumaraswami Latha , Liakopoulos Vassilios , Lui Siu-Fai , Ulasi Ifeoma , Andreoli Sharon , Balducci Alessandro , Dupuis Sophie , Harris Tess , Hradsky Anne , Knight Richard , Kumar Sajay , Ng Maggie , Poidevin Alice , Saadi Gamal , Tong Allison 
Published: March 2021

Living with chronic kidney disease (CKD) is associated with hardships for patients and their care-partners. Empowering patients and their care-partners, including family members or friends involved in their care, may help minimize burden and consequences of CKD related symptoms to enable life participation. There is a need to broaden the focus on living well with kidney disease and re-engagement in life, including emphasis on patients being in control. The World Kidney Day (WKD) Joint Steering Committee has declared 2021 the year of “Living Well with Kidney Disease” in an effort to increase education and awareness on the important goal of patient empowerment and life participation. This calls for the development and implementation of validated patient-reported outcome measures to assess and address areas of life participation in routine care. It could be supported by regulatory agencies as a metric for quality care or to support labelling claims for medicines and devices. Funding agencies could establish targeted calls for research that address the priorities of patients. Patients with kidney disease and their care-partners should feel supported to live well through concerted efforts by kidney care communities including during pandemics. In the overall wellness program for kidney disease patients, the need for prevention should be reiterated. Early detection with prolonged course of wellness despite kidney disease, after effective secondary and tertiary prevention programs, should be promoted. WKD 2021 continues to call for increased awareness of the importance of preventive measures throughout populations, professionals and policy makers, applicable to both developed and developing countries.
PUBLIC SPEAKING ABILITY THROUGH FOCUS GROUP DISCUSSION
Authors: Yulianti Tien 
Published: March 2021

The purpose of this research is to develop a Focus Group Discussion (FGD) model in learning personality development as an effort to improve students' public speaking skills. Through the FGD learning model students are invited to have the ability to think critically, creatively and innovatively in preparing presentations and discussions in a group. The results of the implementation of the FGD model in learning are expected to be able to develop students in an effort to improve public speaking skills, so they have competitiveness in facing of society 5.0. This research phase refers to the six steps of developing the ASSURE model. Development of FGD learning model in the form of presentations and discussions conducted online as well as gathering audience opinion data based on the specified themes. The object is the students who take courses in Personal Development and subject is public speaking. The results obtained is a maximum value=10 based on 10 components of public speaking skills assessment, an average score=8.1, and a standard deviation=1.8. The grade is divided into A (Excellence), B (Good), and E (Fail)
CAN INNOVATION BE TAUGHT?
Authors: Racoviță Andreea Ștefania , Paik S. , Milian C. T. 
Published: March 2021

‘We live in a world where change is exponential and we are helping to prepare students forjobs that don’t yet exist, using technologies that have not yet been invented, in order to solveproblems that we don’t know are problems yet’- Arti Kumar [1]Progress in the medical field is driven by innovation in technology. This holds true all themore when looking at the surgical discipline: for centuries, better visualization allowed for greaterunderstanding and, ultimately, more advanced instruments, procedures, and outcomes. But, as thegrowth of technology is accelerating even further, making use of the full potential of emergingtechnologies has become more and more difficult. A promising way to overcome this challenge isthe revolution of our medical education system.The IRCAD center, recognized worldwide as the reference center for Minimally InvasiveSurgery leverages this interest through a unique philosophy of incubating talents for surgicalinnovation. As such, the B.E.S.T. (Business Engineering and Surgical Technology) teachingmethod consists of two components: online and on-site.Students access MOOCs (Massive Open Online Courses) by world-renowned faculty andcorresponding quizzes, along with the possibility of interacting in a chat with the speaker [2].Afterward, among the online participants from all around the world, 15 medical and 15engineering and/or business students are selected each year for an intensive onsite experience basedon the online course results, curriculum vitae and a letter of intent. Participants learn from a mixtureof workshops in engineering and interventional radiology, form entrepreneurship team projects,train in laparoscopy, robotic surgery and flexible endoscopy on living swine models and simulators.Most remarkably, despite the course being free of charge and providing such a vast variety ofskills, the number of participants compared to that of faculty members is yet in favor of the latterwith a ratio of 30:34. Finally, experts such as surgeons, engineers, entrepreneurs, venture capitalists,and scientists assess and award the delivered team projects and provisional patents are filed.Laparoscopy skills are also quantified and rewarded. The method has been proven to be wellreceived and successful in improving students’ performances, regardless of their background [3-4].
When provided with the right resources, people are empowered to start wondering. Doubt andfear of failure recedes in the face of the possibilities lying within the challenges. Thus, informingabout this innovative teaching format serves not only as an invitation for students but also calls foraction among professionals in Romania to step to the forefront and lead the way in early medicaleducation by collaborating and establishing the needed infrastructure.
UNUSUAL PRESENTATION OF ACUTE INTESTINAL OBSTRUCTION DUE TO TRANSVERSE COLON VOLVULUS IN LATE PREGNANCY
Authors: Haidar Muad Gamil M. , Sharaf Nuha Ahmed H. , Al-Dankali Mayada Mohamed 
Published: March 2021

Transverse colon volvulus is the rarest type of colonic volvulus, with a higher morbidity and mortality rate. In pregnancy, intestinal obstruction due to transverse colon volvulus is rare and seldom reported, and its timely diagnosis can be difficult. We report an unusual case of transverse colon volvulus in a young female at late-term pregnancy. A 28-years-old, pregnant woman, gravida 2, para 1, at 34 weeks of gestation, presented with progressive abdominal pain and distention, commencing about 12 hours prior to admission, associated with vomiting and obstipation. Vital signs were stable. However, the abdomen was asymmetrically hugely distended. The initial abdominal ultrasound showed a single viable intrauterine fetus and dilated loops of bowels. As fetal distress progressed throughout the admission, a laparotomy was performed, which revealed an unexpected transverse colonic volvulus. Resection of the twisted segment and primary anastomosis were performed, followed by a cesarean section to deliver the baby. The mother made a satisfactory recovery. Although this patient’s preoperative clinical findings suggested colonic obstruction, the diagnosis of transverse colonic volvulus was only made intraoperatively and has seldom been previously described. Chronic constipation, the enlarging uterus, and the anatomical redundancy of the transverse colon may have been contributing factors. Transverse colon volvulus in late pregnancy is uncommon. Early diagnosis and prompt surgical intervention can significantly minimize maternal and fetal mortality.
Species Diversity Induces Idiosyncratic Effects on Litter Decomposition in a Degraded Meadow Steppe
Authors: Naeem Iqra , Asif Talal , Wu Xuefeng , Hassan Nazim , Yiming Liu , Wang Hongjun , Wang Ling , Wang Deli 
Published: March 2021

Litter decomposition is a fundamental path for nutrient cycling in a natural ecosystem. However, it remains unclear how species diversity, including richness and evenness, affects the decomposition dynamics in the context of grassland degradation. Using a litter bag technique, we investigated the litter-mixing effects of two coexisting dominant species (Leymus chinensis Lc and Phragmites australis Pa), as monocultures and mixtures with evenness (Lc:Pa) from M1 (30:70%), M2 (50:50%), and M3 (70:30%), on decomposition processes over time (60 and 365 days). The litter bags were placed on the soil surface along a degradation gradient [near pristine (NP), lightly degraded (LD), and highly degraded (HD)]. We found that 1) mass loss in mixture compositions was significantly and positively correlated with initial nitrogen (N) and cellulose contents; 2) litter mixing (richness and evenness) influenced decomposition dynamics individually and in interaction with the incubation days and the degradation gradients; 3) in a general linear model (GLM), nonadditive antagonistic effects were more prominent than additive or neutral effects in final litter and nutrients except for carbon (C); and 4) in nutrients (C, N, lignin) and C/N ratio, additive effects shifted to nonadditive with incubation time. We speculated that the occurrence of nonadditive positive or negative effects varied with litter and nutrients mass remaining in each degraded gradient under the mechanism of initial litter quality of monoculture species, soil properties of experimental sites, and incubation time. Our study has important implications for grassland improvement and protection by considering species biodiversity richness, as well as species evenness.
Identification of an Individualized Immune-Related Prognostic Risk Score in Lung Squamous Cell Cancer
Authors: Zhuang Yuan , Li Sihan , Liu Chang , Li Guang 
Published: March 2021

Background: Lung squamous cell carcinoma (LUSC) is one of the most common histological subtypes of non-small cell lung cancer (NSCLC), and its morbidity and mortality are steadily increasing. The purpose of this study was to study the relationship between the immune-related gene (IRGs) profile and the outcome of LUSC in patients by analyzing datasets from The Cancer Genome Atlas (TCGA).Methods: We obtained publicly available LUSC RNA expression data and clinical survival data from The Cancer Genome Atlas (TCGA), and filtered IRGs based on The ImmPort database. Then, we identified risk immune-related genes (r-IRGs) for model construction using Cox regression analysis and defined the risk score in this model as the immune gene risk index (IRI). Multivariate analysis was used to verify the independent prognostic value of IRI and its association with other clinicopathological features. Pearson correlation analysis was used to explore the molecular mechanism affecting the expression of IRGs and the correlation between IRI and immune cell infiltration.Results: We screened 15 r-IRGs for constructing the risk model. The median value of IRI stratified the patients and there were significant survival differences between the two groups (p = 4.271E-06). IRI was confirmed to be an independent prognostic factor (p &lt; 0.001) and had a close correlation with the patients' age (p &lt; 0.05). Interestingly, the infiltration of neutrophils or dendritic cells was strongly upregulated in the high-IRI groups (p &lt; 0.05). Furthermore, by investigating differential transcription factors (TFs) and functional enrichment analysis, we explored potential mechanisms that may affect IRGs expression in tumor cells.Conclusion: In short, this study used 15 IRGs to build an effective risk prediction model, and demonstrated the significance of IRGs-based personalized immune scores in LUSC prognosis.
Comparison of Two Strategies for Prophylactic Donor Lymphocyte Infusion in Patients With Refractory/Relapsed Acute Leukemia
Authors: Su Qiongqiong , Fan Zhiping , Huang Fen , Xu Na , Nie Danian , Lin Dongjun , Guo Ziwen , Shi Pengcheng , Wang Zhixiang , Jiang Ling , Sun Jing , Jiang Zujun , Liu Qifa , Xuan Li 
Published: March 2021

Prophylactic donor lymphocyte infusion (pDLI) could reduce relapse in patients with refractory/relapsed acute leukemia (RRAL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), but optimal timing of pDLI remains uncertain. We compared the outcomes of two strategies for pDLI based on time from transplant and minimal residual disease (MRD) status in patients with RRAL. For patients without grade II–IV acute graft-versus-host disease (aGVHD) on day +60, pDLI was given on day +60 regardless of MRD in cohort 1, and was given on day +90 unless MRD was positive on day +60 in cohort 2. A total of 161 patients with RRAL were enrolled, including 83 in cohort 1 and 78 in cohort 2. The extensive chronic GVHD (cGVHD) incidence in cohort 2 was lower than that in cohort 1 (10.3% vs. 27.9%, P = 0.006) and GVHD-free/relapse-free survival (GRFS) in cohort 2 was superior to that in cohort 1 (55.1% vs. 41.0%, P = 0.042). The 2-year relapse rate, overall and leukemia-free survival were comparable between the two cohorts (29.0% vs. 28.2%, P = 0.986; 63.9% vs. 64.1%, P = 0.863; 57.8% vs. 61.5%, P = 0.666). Delaying pDLI to day +90 based on MRD for patients with RRAL undergoing allo-HSCT could lower extensive cGVHD incidence and improve GRFS without increasing incidence of leukemia relapse compared with pDLI on day +60.
Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma via Multi-Parametric MRI Radiomics
Authors: Zhang Yang , Shu Zhenyu , Ye Qin , Chen Junfa , Zhong Jianguo , Jiang Hongyang , Wu Cuiyun , Yu Taihen , Pang Peipei , Ma Tianshi , Lin Chunmiao 
Published: March 2021

ObjectivesTo systematically evaluate and compare the predictive capability for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients based on radiomics from multi-parametric MRI (mp-MRI) including six sequences when used individually or combined, and to establish and validate the optimal combined model.MethodsA total of 195 patients confirmed HCC were divided into training (n = 136) and validation (n = 59) datasets. All volumes of interest of tumors were respectively segmented on T2-weighted imaging, diffusion-weighted imaging, apparent diffusion coefficient, artery phase, portal venous phase, and delay phase sequences, from which quantitative radiomics features were extracted and analyzed individually or combined. Multivariate logistic regression analyses were undertaken to construct clinical model, respective single-sequence radiomics models, fusion radiomics models based on different sequences and combined model. The accuracy, sensitivity, specificity and area under the receiver operating characteristic curve (AUC) were calculated to evaluate the performance of different models.ResultsAmong nine radiomics models, the model from all sequences performed best with AUCs 0.889 and 0.822 in the training and validation datasets, respectively. The combined model incorporating radiomics from all sequences and effective clinical features achieved satisfactory preoperative prediction of MVI with AUCs 0.901 and 0.840, respectively, and could identify the higher risk population of MVI (P &lt; 0.001). The Delong test manifested significant differences with P &lt; 0.001 in the training dataset and P = 0.005 in the validation dataset between the combined model and clinical model.ConclusionsThe combined model can preoperatively and noninvasively predict MVI in HCC patients and may act as a usefully clinical tool to guide subsequent individualized treatment.
Contrasting Effects of Fasting on Liver-Adipose Axis in Alcohol-Associated and Non-alcoholic Fatty Liver
Authors: Rasineni Karuna , Jordan Clayton W. , Thomes Paul G. , Kubik Jacy L. , Staab Elizabeth M. , Sweeney Sarah A. , Talmon Geoffrey A. , Donohue Terrence M. , McNiven Mark A. , Kharbanda Kusum K. , Casey Carol A. 
Published: March 2021

Background: Fatty liver, a major health problem worldwide, is the earliest pathological change in the progression of alcohol-associated (AFL) and non-alcoholic fatty liver disease (NAFL). Though the causes of AFL and NAFL differ, both share similar histological and some common pathophysiological characteristics. In this study, we sought to examine mechanisms responsible for lipid dynamics in liver and adipose tissue in the setting of AFL and NAFL in response to 48 h of fasting.Methods: Male rats were fed Lieber-DeCarli liquid control or alcohol-containing diet (AFL model), chow or high-fat pellet diet (NAFL model). After 6–8 weeks of feeding, half of the rats from each group were fasted for 48 h while the other half remained on their respective diets. Following sacrifice, blood, adipose, and the liver were collected for analysis.Results: Though rats fed AFL and NAFL diets both showed fatty liver, the physiological mechanisms involved in the development of each was different. Here, we show that increased hepatic de novo fatty acid synthesis, increased uptake of adipose-derived free fatty acids, and impaired triglyceride breakdown contribute to the development of AFL. In the case of NAFL, however, increased dietary fatty acid uptake is the major contributor to hepatic steatosis. Likewise, the response to starvation in the two fatty liver disease models also varied. While there was a decrease in hepatic steatosis after fasting in ethanol-fed rats, the control, chow and high-fat diet-fed rats showed higher levels of hepatic steatosis than pair-fed counterparts. This diverse response was a result of increased adipose lipolysis in all experimental groups except fasted ethanol-fed rats.Conclusion: Even though AFL and NAFL are nearly histologically indistinguishable, the physiological mechanisms that cause hepatic fat accumulation are different as are their responses to starvation.