bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making an Onboard Reference Map From MRO/CTX Imagery for Mars 2020 Lander Vision System
Authors: Cheng Yang , Ansar Adnan , Johnson Andrew 
Published: July 2021

AbstractThe Mars 2020 rover, Perseverance, landed in Jezero crater (18.4663°N, 77.4298°E) on February 18, 2021 to collect samples from Mars that could be returned to Earth by a future Mars Sample Return campaign. While providing a rich sampling opportunity, Jezero also contains numerous landing hazards including scarps, canyons, mesas, dune fields, rock fields, and smaller craters. The Mars 2020 onboard inertial navigation system, which is the same as that used by the Mars Science Laboratory (MSL), only provides a very coarse inertially propagated position, which can have error as large as 3.2 km. The Lander Vision System (LVS) was added to Mars 2020 to reduce this position knowledge error to less than 40 m with respect to an on‐board reference map of the landing area. LVS uses a reference map on board to compare with the descent images for lander localization during the terminal stage of Entry, Descent and Landing (EDL). Because the reference map is used directly during EDL, it is critical that it have as little spatial and photometric error as possible. Photometrically, it should resemble as much as possible the real descent images to allow reliable terrain matching. Spatially, it should match as faithfully as possible the real, underlying terrain and contribute minimal error to the final localization solution. On February 18, 2021, the LVS reference map passed its ultimate test. The LVS system executed Terrain Relative Navigation (TRN) flawlessly based on the LVS reference map. In addition to its use for TRN, the local hazard map is also registered to the LVS reference map so that the safe target selection (STS) system can select a safe and reachable landing site. The final error between the site targeted by the STS system and the real landing site is estimated at only 5 m. The exceptional performance of LVS indicates that the reference map met mission requirements with comfortable margin. LVS on Mars 2020 represents the first ever use of a reference map during spacecraft EDL. This breakthrough will have profound implications for future lander missions and the scope of scientific inquiry they are able to address. In this paper, we will describe the necessary precursor steps to building the Jezero Crater LVS map, including the methodology to dejitter Context Imager (CTX) images, improve the CTX sensor model, as well as the process used to validate the LVS map accuracy.
Assessing CryoSat‐2 Antarctic Snow Freeboard Retrievals Using Data From ICESat‐2
Authors: Fons S. W. , Kurtz N. T. , Bagnardi M. , Petty A. A. , Tilling R. L. 
Published: July 2021

AbstractNASA's Ice, Cloud, and land Elevation Satellite‐2 (ICESat‐2) laser altimeter launched in Fall 2018, providing an invaluable addition to the polar altimetry record generated by ESA's CryoSat‐2 radar altimeter. The simultaneous operation of these two satellite altimeters enables unique comparison studies of sea ice altimetry, utilizing the different frequencies and profiling strategies of the two instruments. Here, we use freeboard data from ICESat‐2 to assess Antarctic snow freeboard retrievals from CryoSat‐2. We first discuss updates made to a previously published CryoSat‐2 retrieval process and show how this Version 2 algorithm improves upon the original method by comparing the new retrievals to ICESat‐2 in specific along‐track profiles as well as on the basin‐scale. In two near‐coincident along‐track profiles, we find mean snow freeboard differences (standard deviations of differences) of 0.3 (9.3) and 7.6 cm (9.6 cm) with 25 km binned correlation coefficients of 0.77 and 0.89. Monthly mean freeboard differences range between −2.9 (10.8) and 6.6 cm (16.8 cm) basin wide, with the largest differences typically occurring in Austral fall months that is hypothesized to be related to new ice growth and the use of static snow backscatter coefficients in the retrieval. Monthly mean correlation coefficients range between 0.57 and 0.80. While coincident data show good agreement between the two sensors, they highlight issues related to geometric and frequency sampling differences that can impact the freeboard distributions.
Mid‐Infrared Spectroscopy of Anorthosite Samples From Near Manicouagan Crater, Canada, as Analogue for Remote Sensing of Mercury and Other Terrestrial Solar System Objects
Authors: Reitze Maximilian P. , Weber Iris , Morlok Andreas , Hiesinger Harald , Bauch Karin E. , Stojic Aleksandra N. , Helbert Jörn 
Published: July 2021

AbstractWe investigated mid‐infrared reflectance spectra of anorthosite samples from Mt. Briand near the Manicouagan impact structure. Microprobe analyses of the plagioclase minerals reveal that they have a similar chemical composition (labradoritic), which is corroborated by the location of the Christiansen Feature at around 7.96 m (1256 cm−1). However, their respective spectral shapes differ from each other in the region of the reststrahlen bands. This is linked to the degree of Al,Si order within the plagioclase minerals, which also correlates with the previously assumed distance of the sample site to the impact melt. Powdering and sieving led to remarkable changes in the spectra resulting from different mechanical stability of minerals contained in the sample. Our data show that even very weakly shocked (6–10 GPa, shockstage S2) anorthosites could show spectra of Al,Si disordered plagioclase which we attribute to post shock heating after the impact shock. Consequently, the degree of Al,Si order has to be taken into account in the interpretation of remote sensing data. A comparison of synthetic linear mixture with an average Mercury spectrum reveals the possible presence of more or less anorthositic material with reduced degree of Al,Si order of the plagioclase component on Mercury's surface. The results of our study are helpful for the interpretation of data returned by space missions, especially for MERTIS ‐ an infrared spectrometer on its way to Mercury.
Structural Evolution of a Crustal‐Scale Seismogenic Fault in a Magmatic Arc: The Bolfin Fault Zone (Atacama Fault System)
Authors: Masoch Simone , Gomila Rodrigo , Fondriest Michele , Jensen Erik , Mitchell Thomas , Pennacchioni Giorgio , Cembrano José , Di Toro Giulio 
Published: July 2021

AbstractHow major crustal‐scale seismogenic faults nucleate and evolve in crystalline basements represents a long‐standing, but poorly understood, issue in structural geology and fault mechanics. Here, we address the spatio‐temporal evolution of the Bolfin Fault Zone (BFZ), a >40‐km‐long exhumed seismogenic splay fault of the 1000‐km‐long strike‐slip Atacama Fault System. The BFZ has a sinuous fault trace across the Mesozoic magmatic arc of the Coastal Cordillera (Northern Chile) and formed during the oblique subduction of the Aluk plate beneath the South American plate. Seismic faulting occurred at 5–7 km depth and ≤ 300°C in a fluid‐rich environment as recorded by extensive propylitic alteration and epidote‐chlorite veining. Ancient (125–118 Ma) seismicity is attested by the widespread occurrence of pseudotachylytes. Field geologic surveys indicate nucleation of the BFZ on precursory geometrical anisotropies represented by magmatic foliation of plutons (northern and central segments) and andesitic dyke swarms (southern segment) within the heterogeneous crystalline basement. Seismic faulting exploited the segments of precursory anisotropies that were optimal to favorably oriented with respect to the long‐term far‐stress field associated with the oblique ancient subduction. The large‐scale sinuous geometry of the BFZ resulted from the hard linkage of these anisotropy‐pinned segments during fault growth.
Cord blood metabolic signatures predictive of childhood overweight and rapid growth
Authors: Handakas Evangelos , Keski-Rahkonen Pekka , Chatzi Lida , Alfano Rossella , Roumeliotaki Theano , Plusquin Michelle , Maitre Léa , Richiardi Lorenzo , Brescianini Sonia , Scalbert Augustin , Robinot Nivonirina , Nawrot Tim , Sassi Franco , Vrijheid Martine , Vineis Paolo , Robinson Oliver 
Published: July 2021

AbstractIntroductionMetabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy and overweight in early childhood in four European birth cohorts.MethodsUntargeted liquid chromatography-mass spectrometry metabolomic profiles were measured in cord blood from 399 newborns from four European cohorts (ENVIRONAGE, Rhea, INMA and Piccolipiu). Rapid growth in the first year of life and overweight in childhood was defined with reference to WHO growth charts. Metabolome-wide association scans for rapid growth and overweight on over 4500 metabolic features were performed using multiple adjusted logistic mixed-effect models and controlling the false discovery rate (FDR) at 5%. In addition, we performed a look-up analysis of 43 pre-annotated metabolites, previously associated with birthweight or rapid growth.ResultsIn the Metabolome-Wide Association Study analysis, we identified three and eight metabolites associated with rapid growth and overweight, respectively, after FDR correction. Higher levels of cholestenone, a cholesterol derivative produced by microbial catabolism, were predictive of rapid growth (p = 1.6 × 10−3). Lower levels of the branched-chain amino acid (BCAA) valine (p = 8.6 × 10−6) were predictive of overweight in childhood. The area under the receiver operator curve for multivariate prediction models including these metabolites and traditional risk factors was 0.77 for rapid growth and 0.82 for overweight, compared with 0.69 and 0.69, respectively, for models using traditional risk factors alone. Among the 43 pre-annotated metabolites, seven and five metabolites were nominally associated (P < 0.05) with rapid growth and overweight, respectively. The BCAA leucine, remained associated (1.6 × 10−3) with overweight after FDR correction.ConclusionThe metabolites identified here may assist in the identification of children at risk of developing obesity and improve understanding of mechanisms involved in postnatal growth. Cholestenone and BCAAs are suggestive of a role of the gut microbiome and nutrient signalling respectively in child growth trajectories.
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease
Authors: Liu Xue-qi , Jiang Ling , Li Yuan-yuan , Huang Yue-bo , Hu Xue-ru , Zhu Wei , Wang Xian , Wu Yong-gui , Meng Xiao-ming , Qi Xiang-ming 
Published: July 2021

AbstractDiabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options. Wogonin is a flavonoid derived from the root of Scutellaria baicalensis Georgi, which has shown a potent renoprotective effect. But the mechanisms of action in DKD are not fully elucidated. In this study, we investigated the effects of wogonin on glomerular podocytes in DKD using mouse podocyte clone 5 (MPC5) cells and diabetic mice model. MPC5 cells were treated with high glucose (30 mM). We showed that wogonin (4, 8, 16 μM) dose-dependently alleviated high glucose (HG)-induced MPC5 cell damage, accompanied by increased expression of WT-1, nephrin, and podocin proteins, and decreased expression of TNF-α, MCP-1, IL-1β as well as phosphorylated p65. Furthermore, wogonin treatment significantly inhibited HG-induced apoptosis in MPC5 cells. Wogonin reversed HG-suppressed autophagy in MPC5 cells, evidenced by increased ATG7, LC3-II, and Beclin-1 protein, and decreased p62 protein. We demonstrated that wogonin directly bound to Bcl-2 in MPC5 cells. In HG-treated MPC5 cells, knockdown of Bcl-2 abolished the beneficial effects of wogonin, whereas overexpression of Bcl-2 mimicked the protective effects of wogonin. Interestingly, we found that the expression of Bcl-2 was significantly decreased in biopsy renal tissue of diabetic nephropathy patients. In vivo experiments were conducted in STZ-induced diabetic mice, which were administered wogonin (10, 20, 40 mg · kg−1 · d−1, i.g.) every other day for 12 weeks. We showed that wogonin administration significantly alleviated albuminuria, histopathological lesions, and p65 NF-κB-mediated renal inflammatory response. Wogonin administration dose-dependently inhibited podocyte apoptosis and promoted podocyte autophagy in STZ-induced diabetic mice. This study for the first time demonstrates a novel action of wogonin in mitigating glomerulopathy and podocytes injury by regulating Bcl-2-mediated crosstalk between autophagy and apoptosis. Wogonin may be a potential therapeutic drug against DKD.
Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response
Authors: Gwili Noha , Jones Stacey J. , Amri Waleed Al , Carr Ian M. , Harris Sarah , Hogan Brian V. , Hughes William E. , Kim Baek , Langlands Fiona E. , Millican-Slater Rebecca A. , Pramanik Arindam , Thorne James L. , Verghese Eldo T. , Wells Geoff , Hamza Mervat , Younis Layla , El Deeb Nevine M. F. , Hughes Thomas A. 
Published: July 2021

Abstract
Background
Breast cancer stem cells (BCSCs) are drivers of therapy-resistance, therefore are responsible for poor survival. Molecular signatures of BCSCs from primary cancers remain undefined. Here, we identify the consistent transcriptome of primary BCSCs shared across breast cancer subtypes, and we examine the clinical relevance of ITGA7, one of the genes differentially expressed in BCSCs.

Methods
Primary BCSCs were assessed using immunohistochemistry and fluorescently labelled using Aldefluor (n = 17). Transcriptomes of fluorescently sorted BCSCs and matched non-stem cancer cells were determined using RNA-seq (n = 6). ITGA7 expression was examined in breast cancers using immunohistochemistry (n = 305), and its functional role was tested using siRNA in breast cancer cells.

Results
Proportions of BCSCs varied from 0 to 9.4%. 38 genes were significantly differentially expressed in BCSCs; genes were enriched for functions in vessel morphogenesis, motility, and metabolism. ITGA7 was found to be significantly downregulated in BCSCs, and low expression significantly correlated with reduced survival in patients treated with chemotherapy, and with chemoresistance in breast cancer cells in vitro.

Conclusions
This study is the first to define the molecular profile of BCSCs from a range of primary breast cancers. ITGA7 acts as a predictive marker for chemotherapy response, in accordance with its downregulation in BCSCs.
Continuous control of classical-quantum crossover by external high pressure in the coupled chain compound CsCuCl3
Authors: Yamamoto Daisuke , Sakurai Takahiro , Okuto Ryosuke , Okubo Susumu , Ohta Hitoshi , Tanaka Hidekazu , Uwatoko Yoshiya 
Published: July 2021

AbstractIn solid materials, the parameters relevant to quantum effects, such as the spin quantum number, are basically determined and fixed at the chemical synthesis, which makes it challenging to control the amount of quantum correlations. We propose and demonstrate a method for active control of the classical-quantum crossover in magnetic insulators by applying external pressure. As a concrete example, we perform high-field, high-pressure measurements on CsCuCl3, which has the structure of weakly-coupled spin chains. The magnetization process experiences a continuous evolution from the semi-classical realm to the highly-quantum regime with increasing pressure. Based on the idea of "squashing” the spin chains onto a plane, we characterize the change in the quantum correlations by the change in the value of the local spin quantum number of an effective two-dimensional model. This opens a way to access the tunable classical-quantum crossover of two-dimensional spin systems by using alternative systems of coupled-chain compounds.
The blue carbon wealth of nations
Authors: Bertram Christine , Quaas Martin , Reusch Thorsten B. H. , Vafeidis Athanasios T. , Wolff Claudia , Rickels Wilfried 
Published: July 2021

AbstractCarbon sequestration and storage in mangroves, salt marshes and seagrass meadows is an essential coastal ‘blue carbon’ ecosystem service for climate change mitigation. Here we offer a comprehensive, global and spatially explicit economic assessment of carbon sequestration and storage in three coastal ecosystem types at the global and national levels. We propose a new approach based on the country-specific social cost of carbon that allows us to calculate each country’s contribution to, and redistribution of, global blue carbon wealth. Globally, coastal ecosystems contribute a mean ± s.e.m. of US$190.67 ± 30 bn yr−1 to blue carbon wealth. The three countries generating the largest positive net blue wealth contribution for other countries are Australia, Indonesia and Cuba, with Australia alone generating a positive net benefit of US$22.8 ± 3.8 bn yr−1 for the rest of the world through coastal ecosystem carbon sequestration and storage in its territory.
Pupil dilation predicts individual self-regulation success across domains
Authors: Maier Silvia U. , Grueschow Marcus 
Published: July 2021

AbstractMultiple theories have proposed that increasing central arousal through the brain’s locus coeruleus—norepinephrine system may facilitate cognitive control and memory. However, the role of the arousal system in emotion regulation is less well understood. Pupil diameter is a proxy to infer upon the central arousal state. We employed an emotion regulation paradigm with a combination of design features that allowed us to dissociate regulation from emotional arousal in the pupil diameter time course of 34 healthy adults. Pupil diameter increase during regulation predicted individual differences in emotion regulation success beyond task difficulty. Moreover, the extent of this individual regulatory arousal boost predicted performance in another self-control task, dietary health challenges. Participants who harnessed more regulation-associated arousal during emotion regulation were also more successful in choosing healthier foods. These results suggest that a common arousal-based facilitation mechanism may support an individual’s self-control across domains.
A systematic review of the usefulness of magnetic resonance imaging in predicting the gait ability of stroke patients
Authors: Imura Takeshi , Mitsutake Tsubasa , Iwamoto Yuji , Tanaka Ryo 
Published: July 2021

AbstractThe usefulness of magnetic resonance imaging (MRI) in predicting gait ability in stroke patients remains unclear. Therefore, MRI evaluations have not yet been standardized in stroke rehabilitation. We performed a systematic review to consolidate evidence regarding the use of MRIs in predicting gait ability of stroke patients. The Medline, Cumulative Index to Nursing and Allied Health Literature, and SCOPUS databases were comprehensively searched. We included all literature published from each source’s earliest date to August 2020. We included 19 studies: 8 were classified as structure- or function-based MRI studies and 11 as neural tract integrity-based MRI studies. Most structure- or function-based MRI studies indicated that damage to motor-related areas (primary motor cortex, corona radiata, internal capsule, and basal ganglia) or insula was related to poor gait recovery. In neural tract integrity-based MRI studies, integrity of the corticospinal tract was related to gait ability. Some studies reported predictive value of the corticoreticular pathway. All included studies had some concerns, at least one, based on the Cochrane risk of bias instrument. This review suggests that MRIs are useful in predicting gait ability of stroke patients. However, we cannot make definitive conclusion regarding the predictive value, due to the lack of quantitative evaluations.
Prediction of survival in patients with advanced, refractory colorectal cancer in treatment with trifluridine/tipiracil: real-world vs clinical trial data
Authors: Fernández Montes Ana , Carmona-Bayonas Alberto , Jimenez-Fonseca Paula , Vázquez Rivera Francisca , Martinez Lago Nieves , Covela Rúa Marta , Cousillas Castiñeiras Antía , Gonzalez Villarroel Paula , De la Cámara Gómez Juan , Méndez José Carlos Méndez , Carriles Fernández Carmen , Sanchez Cánovas Manuel , Garcia García Teresa 
Published: July 2021

AbstractTrifluridine/tipiracil increases overall survival (OS) in patients with refractory, metastatic colorectal cancer (mCRC). A post hoc exploratory analysis of the RECOURSE randomized clinical trial (RCT) established two categories, a good prognosis corresponding to subjects having a low tumor burden and indolent disease. Other models in refractory mCRC are the FAS-CORRECT and Colon Life nomogram. The main objective was to externally validate the prognostic factors of the RECOURSE and FAS-CORRECT trials, and the Colon Life nomogram in a multicenter, real-world series of mCRC treated in 3rd and successive lines with trifluridine/tipiracil. The secondary aim was to develop an OS predictive model, TAS-RECOSMO. Between 2016 and 2019, 244 patients were recruited. Median OS was 8.15 vs 8.12 months for the poor (85% of the subjects) and good (15%) prognosis groups from the RESOURCE trial, respectively, log-rank p = 0.9. The most common grade 3–4 toxicities were neutropenia (17%), asthenia (6%), and anemia (5%). The AFT lognormal model TAS-RECOSMO included six variables: ECOG-PS, KRAS/NRAS/BRAF mutation status, time between diagnosis of metastasis and beginning of trifluridine/tipiracil, NLR, CEA, and alkaline phosphatase. The model’s bootstrapped bias-corrected c-index was 0.682 (95% CI, 0.636–0.722). The factors from the Colon Life model, FAS-CORRECT, and RECOURSE displayed a c-index of 0.690, 0.630, and 0.507, respectively. TAS-RECOSMO, FAS-CORRECT, and the Colon Life nomogram appear to predict OS in patients with refractory mCCR who begin trifluridine/tipiracil treatment in the real world. The prognostic groups of the RECOURCE RCT were unable to capture the situation of real-world subjects treated with trifluridine/tipiracil in this series.