bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex, population origin, age and average digit length as predictors of digit ratio in three large world populations
Authors: Butovskaya Marina , Burkova Valentina , Apalkova Yulia , Dronova Daria , Rostovtseva Victoria , Karelin Dmitriy , Mkrtchyan Ruzan , Negasheva Marina , Batsevich Valery 
Published: April 2021

AbstractRecently, a number of authors have claimed that sexual dimorphism in the second-to-fourth digit ratio (2D:4D) is simply dependent on digit length and is an artifact of allometry. The goal of our study is to verify the validity of these assumptions. The study sample comprised 7,582 individuals (3,802 men and 3,780 women) from three large world populations: Europeans (n = 3043), East Africans (n = 2844), and Central Asians (n = 1695). The lengths of the second and fourth digits on both hands were measured. Digit ratios were computed according to standard procedures. Analyses were conducted separately for each hand for the whole sample and in succession for the three large populations. Additionally, we separately tested four age cohorts (≤ 13, 14–18, 19–30, and 31 ≥ years) to test the effect of developmental allometry. The second and fourth digits showed strong positive linear relationships on both hands, and demonstrated an increase with age; digit length in women from the youngest age cohort was longer or equal to that of men, and shorter than men in older age cohorts. However, the 2D:4D magnitude and its sexual dimorphism remained stable throughout the ontogeny. To test for an allometric effect on 2D:4D, the average digit lengths were calculated. Both sex and population origin were permanent reliable predictors of 2D:4D, whereas average digit length was not. Height was applied as another measure of allometric effect on the limited sample (≤ 30 years) from the European population, along with sex and age. No allometric effect was observed in this case. We conclude that sex differences in 2D:4D are not an artifact of allometry.
Experimental study of non-oxidized and oxidized bitumen obtained from heavy oil
Authors: Djimasbe Richard , Galiullin Eduard A. , Varfolomeev Mikhail A. , Fakhrutdinov Revo Z. , Al-Muntaser Ameen A. , Farhadian Abdolreza 
Published: April 2021

AbstractHeavy oil and vacuum residue were used to obtain road bitumen BND 50/70 using two different methods of steam distillation at 323–362 °C and by oxidation, a method using packed column at temperature of 211–220 °C. The obtained residues using two methods steam distillation and oxidation are known as non-oxidized bitumen and oxidized bitumen, respectively. The products were evaluated using different standards including GOST 33133-2014, GOST 22245-90, and ASTM D5. The results showed that the yield of oxidized bitumen reached a maximal rate of 89.59% wt., while that of non-oxidized bitumen is 55% wt. The softening point of oxidized bitumen is 49–57 °C compared to non-oxidized bitumen (46–49 °C). Remarkably, the previous softening point and penetrability of 47–71 points of oxidized bitumen are consistent with norms to BND 50/70 bitumen, according standard. The non-oxidized bitumen has a relatively low softening point and a higher penetration value of 71–275, which refers to BND 200/300 bitumen. Comparatively, the use of a packed column is beneficial than the steam distillation, due to high capability of the nozzles to strengthens contact between feedstock and compressed air in the reaction zone and decreases the reaction time to 4.15 h.
Exhausting repetitive piano tasks lead to local forearm manifestation of muscle fatigue and negatively affect musical parameters
Authors: Goubault Etienne , Verdugo Felipe , Pelletier Justine , Traube Caroline , Begon Mickaël , Dal Maso Fabien 
Published: April 2021

AbstractMuscle fatigue is considered as a risk factor for developing playing-related muscular disorders among professional pianists and could affect musical performance. This study investigated in 50 pianists the effect of fatiguing repetitive piano sequences on the development of forearm muscle fatigue and on piano performance parameters. Results showed signs of myoelectric manifestation of fatigue in the 42-electromyographic bipolar electrodes positioned on the forearm to record finger and wrist flexor and extensor muscles, through a significant non-constant decrease of instantaneous median frequency during two repetitiveDigital(right-hand 16-tones sequence) andChord(right-hand chords sequence) excerpts, with extensor muscles showing greater signs of fatigue than flexor muscles. In addition, muscle fatigue negatively affected key velocity, a central feature of piano sound intensity, in bothDigitalandChordexcerpts, and note-events, a fundamental aspect of musicians’ performance parameter, in theChordexcerpt only. This result highlights that muscle fatigue may alter differently pianists’ musical performance according to the characteristics of the piece played.
ANMAF: an automated neuronal morphology analysis framework using convolutional neural networks
Authors: Tong Ling , Langton Rachel , Glykys Joseph , Baek Stephen 
Published: April 2021

AbstractMeasurement of neuronal size is challenging due to their complex histology. Current practice includes manual or pseudo-manual measurement of somatic areas, which is labor-intensive and prone to human biases and intra-/inter-observer variances. We developed a novel high-throughput neuronal morphology analysis framework (ANMAF), using convolutional neural networks (CNN) to automatically contour the somatic area of fluorescent neurons in acute brain slices. Our results demonstrate considerable agreements between human annotators and ANMAF on detection, segmentation, and the area of somatic regions in neurons expressing a genetically encoded fluorophore. However, in contrast to humans, who exhibited significant variability in repeated measurements, ANMAF produced consistent neuronal contours. ANMAF was generalizable across different imaging protocols and trainable even with a small number of humanly labeled neurons. Our framework can facilitate more rigorous and quantitative studies of neuronal morphology by enabling the segmentation of many fluorescent neurons in thick brain slices in a standardized manner.
Studying information recurrence, gatekeeping, and the role of communities during internet outages in Venezuela
Authors: Thomas Pamela Bilo , Saldanha Emily , Volkova Svitlana 
Published: April 2021

AbstractMany authoritarian regimes have taken to censoring internet access in order to stop the spread of misinformation, restrict citizens from discussing certain topics, and prevent mobilization, among other reasons. There are several theories about the effectiveness of censorship. Some suggest that censorship will effectively limit the flow of information, whereas others predict that a backlash will form, resulting in ultimately more discussion about the topic. In this work, we analyze the role of communities and gatekeepers during multiple internet outages in Venezuela in January 2019. First, we measure how critical information (e.g., entities and hashtags) spreads during outages focusing on information recurrence and burstiness within and across language and location communities. We discover that information bursts tend to cross both language and location community boundaries rather than being limited to a single community during several outages. Then we identify users who play central roles and propose a novel method to detect gatekeepers—users who prevent critical information from spreading across communities during outages. We show that bilingual and English-speaking users play more central roles compared to Spanish-speaking users, but users inside and outside Venezuela have similar distribution of centrality. Finally, we measure the differences in social network structure before and after each outage event and discuss its effect on how information spreads. We find that with each outage event social connections tend to get less connected with higher mean shortest path, indicating that the effect of censorship makes it harder for information to spread.
Prevalence and risk factors for myopia in Taiwanese diabetes mellitus patients: a multicenter case–control study in Taiwan
Authors: Lin Hsin-Ting , Zheng Cai-Mei , Fang Yu-Ann , Liu Ju-Chi , Wu Yun-Chun , Chang Yun-Hsiang , Chen Jiann-Torng , Liang Chang-Min , Chang Tian-Jong , Zheng Jing-Quan , Tai Ming-Cheng , Lin Yuh-Feng 
Published: April 2021

AbstractThis population-based retrospective cohort study investigated the prevalence of myopia among patients with Type 1 and Type 2 diabetes mellitus (DM) and evaluate risk factors for myopia in these groups. Records from 2000 to 2012 with at least one year of follow-up from the Taiwan National Health Insurance Research Database were included. This study included 35,538 patients with DM and 71,076 patients without DM. Patients with DM had a significantly higher adjusted hazard ratio for myopia in all age groups and both sexes compared with patients without DM. The subgroup analysis results revealed that the rates of myopia and astigmatism were significantly higher among patients with DM compared with patients without DM aged < 60 years. However, the rates of high myopia or myopia progression to high myopia did not differ significantly between the two groups. These findings indicate that DM is a critical risk factor for myopia and astigmatism among patients aged < 60 years. Therefore, active surveillance and earlier treatment of myopia are critical for patients with DM.
High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching
Authors: Blazejewski Sara M. , Bennison Sarah A. , Liu Xiaonan , Toyo-oka Kazuhito 
Published: April 2021

AbstractKinases are essential regulators of a variety of cellular signaling processes, including neurite formation—a foundational step in neurodevelopment. Aberrant axonal sprouting and failed regeneration of injured axons are associated with conditions like traumatic injury, neurodegenerative disease, and seizures. Investigating the mechanisms underlying neurite formation will allow for identification of potential therapeutics. We used a kinase inhibitor library to screen 493 kinase inhibitors and observed that 45% impacted neuritogenesis in Neuro2a (N-2a) cells. Based on the screening, we further investigated the roles of Aurora kinases A, B, and C and Nuak kinases 1 and 2. The roles of Aurora and Nuak kinases have not been thoroughly studied in the nervous system. Inhibition or overexpression of Aurora and Nuak kinases in primary cortical neurons resulted in various neuromorphological defects, with Aurora A regulating neurite initiation, Aurora B and C regulating neurite initiation and elongation, all Aurora kinases regulating arborization, and all Nuak kinases regulating neurite initiation and elongation and arborization. Our high-throughput screening and analysis of Aurora and Nuak kinases revealed their functions and may contribute to the identification of therapeutics.
Effect of glyphosate and P on the growth and nutrition of Coffea arabica cultivars and on weed control
Authors: da Costa Yanna Karoline Santos , Ribeiro Nagilla Moraes , de Moura Guilherme Cesar Pereira , Oliveira Artur Rodrigues , Bianco Silvano , Alcántara-de la Cruz Ricardo , de Carvalho Leonardo Bianco 
Published: April 2021

AbstractThe effect of the phosphorus (P) and glyphosate interactions on the growth and nutrition of Arabica coffee cultivars (Coffea arabica), as well as on the control of Ipomoea grandifolia and Urochloa decumbens, was evaluated. Catuaí-Amarelo/IAC-62 and Catuaí-Vermelho/IAC-144 cultivars did not show glyphosate poisoning, regardless of the soil P content. However, glyphosate reduced the growth of Catuaí-Vermelho/IAC-144. In addition, the soil P content influenced the height, leaf area and dry matter of Catuaí-Amarelo/IAC-62, and the absorption of P and Ca in both cultivars. On the other hand, glyphosate efficiently controlled U. decumbens but not I. grandifolia. Glyphosate effectiveness on I. grandifolia decreased as the soil P content increased. In addition, the soil P content and the glyphosate influenced the P content in I. grandifolia and U. decumbens plants. The soil P content influenced the growth and absorption of other nutrients by coffee plants as well as glyphosate effectiveness on weed control.
Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior
Authors: Wawro Adam M. , Gajera Chandresh R. , Baker Steven A. , Leśniak Robert K. , Fischer Curt R. , Saw Nay L. , Shamloo Mehrdad , Montine Thomas J. 
Published: April 2021

AbstractImbalance of excitatory and inhibitory neurotransmission is implicated in a wide range of psychiatric and neurologic disorders. Here we tested the hypothesis that insertion of a methyl group on the stereogenic alpha carbon of l-Glu or l-Gln would impact the γ-aminobutyric acid (GABA) shunt and the glutamate-glutamine cycle. (S)-2-methylglutamate, or (S)-2MeGlu, was efficiently transported into brain and synaptosomes where it was released by membrane depolarization in a manner equivalent to endogenous l-Glu. (R)-2MeGlu was transported less efficiently into brain and synaptosomes but was not released by membrane depolarization. Each enantiomer of 2MeGlu had limited activity across a panel of over 30 glutamate and GABA receptors. While neither enantiomer of 2MeGlu was metabolized along the GABA shunt, (S)-2MeGlu was selectively converted to (S)-2-methylglutamine, or (S)-2MeGln, which was subsequently slowly hydrolyzed back to (S)-2MeGlu in brain. rac-2MeGln was also transported into brain, with similar efficiency as (S)-2MeGlu. A battery of behavioral tests in young adult wild type mice showed safety with up to single 900 mg/kg dose of (R)-2MeGlu, (S)-2MeGlu, or rac-2MeGln, suppressed locomotor activity with single ≥ 100 mg/kg dose of (R)-2MeGlu or (S)-2MeGlu. No effect on anxiety or hippocampus-dependent learning was evident. Enantiomers of 2MeGlu and 2MeGln show promise as potential pharmacologic agents and imaging probes for cells that produce or transport l-Gln.
Intensifying cropping systems through doubled-up legumes in Eastern Zambia
Authors: Mwila Mulundu , Mhlanga Blessing , Thierfelder Christian 
Published: April 2021

AbstractDeclining soil fertility and negative impacts of climate effects threaten the food security of millions in Africa. Conservation Agriculture (CA) is a promising strategy to address these challenges. However, lack of viable economic entry points and short-term benefits for smallholders limit its adoption. Legume intensification can possibly increase the output per unit area, thus making the system more attractive. Rotations of maize with intensified legume systems were tested for three consecutive years under ridge and furrow (RF) tillage and CA to investigate: (a) increases in productivity of legumes and the subsequent maize crop; (b) changes in land equivalent ratios (LERs) and; (c) improved total system productivity. Results showed an increase in legume yields when growing two legumes simultaneously, leading to greater LERs (ranging between 1.13 and 1.29). However, there was only a significant season and not a main treatment effect as CA did not outperform RF in both phases of the rotation. Full populations of companion legumes improved overall system productivity, yielding 76.8 GJ ha−1 in a more conducive season while sole cropping of pigeonpea yielded only 4.4 GJ ha−1. We conclude that the doubled-up legumes systems have great potential to improve household food security when integrated into current smallholder farming.
Development of layer-by-layer assembled polyamide-imide membranes for oil sands produced water treatment
Authors: Helali Nusrat , Shamaei Laleh , Rastgar Masoud , Sadrzadeh Mohtada 
Published: April 2021

AbstractThe sustainable expansion of steam-assisted gravity drainage, as one of the most popular enhanced oil recovery methods, strongly depends on the proper management of the produced water. The strict environmental regulations have forced the oil sands industry to treat and reuse the produced water for oil extraction. Membrane separation as a single-step water treatment technique has played an important role in removing multiple-sized contaminants from wastewater. However, fouling limits the widespread application of this technology if the membrane is not modified properly to achieve antifouling propensities. Herein, we used the layer-by-layer assembly technique to sequentially coat the hydrophilic poly(diallyl dimethylammonium chloride) and polyacrylic acid on the surface of the polyamide-imide porous membrane to improve its fouling resistance. The effect of the number of bilayers on fouling and permeation properties was examined. The membrane with the highest fouling resistance and reasonable hydrodynamic permeability of 5.2 LMH/psi was achieved by coating four bilayers. This membrane exhibited a low flux decline of 50.2% and a high flux recovery ratio of 100%, while these numbers for the pristine PAI membrane were 75.9% and 97.8% under similar test conditions. The enhanced antifouling characteristics of the modified membranes indicate the viability of these membranes for oil sands produced water treatment with an easy cleaning procedure. The key parameter that contributed to the enhanced fouling resistance of the bilayer-coated membranes was the improved surface hydrophilicity, which manifests through the reduction of water contact angle from 62° ± 3° for the pristine membrane to 52° ± 2° for surface-modified membranes.
Ultra-high critical current densities of superconducting YBa2Cu3O7-δ thin films in the overdoped state
Authors: Stangl A. , Palau A. , Deutscher G. , Obradors X. , Puig T. 
Published: April 2021

AbstractThe functional properties of cuprates are strongly determined by the doping state and carrier density. We present an oxygen doping study of YBa2Cu3O7-δ (YBCO) thin films from underdoped to overdoped state, correlating the measured charge carrier density, $${n}_{\mathrm{H}}$$

n
H

, the hole doping, p, and the critical current density, $${J}_{c}$$

J
c

. Our results show experimental demonstration of strong increase of $${J}_{c}$$

J
c

with $${n}_{\mathrm{H}}$$

n
H

, up to Quantum Critical Point (QCP), due to an increase of the superconducting condensation energy. The ultra-high $${J}_{c}$$

J
c

achieved, 90 MA cm−2 at 5 K corresponds to about a fifth of the depairing current, i.e. a value among the highest ever reported in YBCO films. The overdoped regime is confirmed by a sudden increase of $${n}_{\mathrm{H}}$$

n
H

, associated to the reconstruction of the Fermi-surface at the QCP. Overdoping YBCO opens a promising route to extend the current carrying capabilities of rare-earth barium copper oxide (REBCO) coated conductors for applications.
Landscape structure affects the sunflower visiting frequency of insect pollinators
Authors: Lajos Károly , Samu Ferenc , Bihaly Áron Domonkos , Fülöp Dávid , Sárospataki Miklós 
Published: April 2021

AbstractMass-flowering crop monocultures, like sunflower, cannot harbour a permanent pollinator community. Their pollination is best secured if both managed honey bees and wild pollinators are present in the agricultural landscape. Semi-natural habitats are known to be the main foraging and nesting areas of wild pollinators, thus benefiting their populations, whereas crops flowering simultaneously may competitively dilute pollinator densities. In our study we asked how landscape structure affects major pollinator groups’ visiting frequency on 36 focal sunflower fields, hypothesising that herbaceous semi-natural (hSNH) and sunflower patches in the landscape neighbourhood will have a scale-dependent effect. We found that an increasing area and/or dispersion of hSNH areas enhanced the visitation of all pollinator groups. These positive effects were scale-dependent and corresponded well with the foraging ranges of the observed bee pollinators. In contrast, an increasing edge density of neighbouring sunflower fields resulted in considerably lower visiting frequencies of wild bees. Our results clearly indicate that the pollination of sunflower is dependent on the composition and configuration of the agricultural landscape. We conclude that an optimization of the pollination can be achieved if sufficient amount of hSNH areas with good dispersion are provided and mass flowering crops do not over-dominate the agricultural landscape.
Enhanced X-ray emission arising from laser-plasma confinement by a strong transverse magnetic field
Authors: Filippov Evgeny D. , Makarov Sergey S. , Burdonov Konstantin F. , Yao Weipeng , Revet Guilhem , Béard Jerome , Bolaños Simon , Chen Sophia N. , Guediche Amira , Hare Jack , Romanovsky Denis , Skobelev Igor Yu. , Starodubtsev Mikhail , Ciardi Andrea , Pikuz Sergey A. , Fuchs Julien 
Published: April 2021

AbstractWe analyze, using experiments and 3D MHD numerical simulations, the dynamic and radiative properties of a plasma ablated by a laser (1 ns, 10$$^{12}$$12–10$$^{13}$$13W/cm$$^2$$2) from a solid target as it expands into a homogeneous, strong magnetic field (up to 30 T) that is transverse to its main expansion axis. We find that as early as 2 ns after the start of the expansion, the plasma becomes constrained by the magnetic field. As the magnetic field strength is increased, more plasma is confined close to the target and is heated by magnetic compression. We also observe that after$$\sim 8$$∼8 ns, the plasma is being overall shaped in a slab, with the plasma being compressed perpendicularly to the magnetic field, and being extended along the magnetic field direction. This dense slab rapidly expands into vacuum; however, it contains only$$\sim 2\%$$∼2%of the total plasma. As a result of the higher density and increased heating of the plasma confined against the laser-irradiated solid target, there is a net enhancement of the total X-ray emissivity induced by the magnetization.
Silk films with nanotopography and extracellular proteins enhance corneal epithelial wound healing
Authors: Luo Yuncin , Kang Kai B. , Sartaj Rachel , Sun Michael G. , Zhou Qiang , Guaiquil Victor H. , Rosenblatt Mark I. 
Published: April 2021

AbstractCorneal wound healing depends on extracellular matrix (ECM) and topographical cues that modulate migration and proliferation of regenerating cells. In our study, silk films with either flat or nanotopography patterned parallel ridge widths of 2000, 1000, 800 nm surfaces were combined with ECMs which include collagen type I (collagen I), fibronectin, laminin, and Poly-d-Lysine to accelerate corneal wound healing. Silk films with 800 nm ridge width provided better cell spreading and wound recovery than other size topographies. Coating 800 nm patterned silk films with collagen I proves to optimally further increased mouse and rabbit corneal epithelial cells growth and wound recovery. This enhanced cellular response correlated with redistribution and increase in size and total amount of focal adhesion. Transcriptomics and signaling pathway analysis suggested that silk topography regulates cell behaviors via actin nucleation ARP-WASP complex pathway, which regulate filopodia formation. This mechanism was further explored and inhibition of Cdc42, a key protein in this pathway, delayed wound healing and decreased the length, density, and alignment of filopodia. Inhibition of Cdc42 in vivo resulted in delayed re-epithelization of injured corneas. We conclude that silk film nanotopography in combination with collagen I constitutes a better substrate for corneal wound repair than either nanotopography or ECM alone.