bluuebunny/crossref_metadata_2025_split huggingface dataset:
Politics of Haya: Embodied Materiality of Piety as Everyday Resistance among British Muslim Women in Ayisha Malik's Fiction
Authors: Saleem Sumera 
Published: September 2021

Abstract
This article explores how an ethical practice of modesty, represented in Ayisha Malik’s novels Sofia Khan Is Not Obliged (2015), and The Other Half of Happiness (2017), serves as an act of everyday resistance in the context of the issue of gender inequality in postcolonial South Asian Britain. It attempts to understand how religious modalities of agency, shown in the form of wearing hijab, operate against the dominant structures of power. However, drawing on Saba Mahmood’s theorisation of women’s agency in Politics of Piety (2004) as an embodied modality of action rather than simply a synonym for resistance to social norms, this article further argues that the female body in this fiction reshapes the understanding of religious experience through the conception of an embodied materiality of everyday resistance.
Probing the effects of primordial black holes on 21-cm EDGES signal along with interacting dark energy and dark matter–baryon scattering
Authors: Halder Ashadul , Pandey Madhurima 
Published: September 2021

ABSTRACT21-cm radio signal has emerged as an important probe in investigating the dark age of the Universe (recombination to reionization). In the current analysis, we explore the combined effects of primordial black holes (PBHs), cooling-off of the baryonic matter due to dark matter (DM)–baryon collisions and interaction of DM and dark energy fluid on the 21-cm brightness temperature. The variation of brightness temperature shows remarkable dependence on DM mass (mχ) and the DM–baryon scattering cross-section (σ0). Bounds in mχ–σ0 parameter space are obtained for different possible PBH masses and for different interacting dark energy (IDE) models. These bounds are estimated based on the observed excess ($-500^{+200}_{-500}$ mK) of 21-cm brightness temperature by Experiment to Detect the Global Epoch of Reionization Signature experiment. Eventually, bounds on PBH mass is also obtained for different values of DM mass and for different IDE model coupling parameters. The compatibility of the constraints of the IDE models, in the estimated bounds is also addressed.
ATOMS: ALMA Three-millimeter Observations of Massive Star-forming regions–VI. On the formation of the ‘L’ type filament in G286.21+0.17
Authors: Zhou Jian-Wen , Liu Tie , Li Jin-Zeng , Liu Hong-Li , Wang Ke , Xu Feng-Wei , Kim Kee-Tae , Lee Chang Won , Dewangan Lokesh , Tatematsu Ken’ichi , Li Shanghuo , Liu Xun-Chuan , Tang Mengyao , Ren Zhiyuan , Zhang Guo-Yin , Zhang Chao , Liu Rong , Luo Qiu-Yi , Ristorcelli Isabelle 
Published: September 2021

ABSTRACT
Filaments play an important role in star formation, but the formation process of filaments themselves is still unclear. The high-mass star-forming clump G286.21+0.17 (G286 for short) that contains an ‘L’ type filament was thought to undergo global collapse. Our high-resolution ALMA band 3 observations resolve the gas kinematics of G286 and reveal two sub-clumps with very different velocities inside it. We find that the ‘blue profile’ (an indicator of gas infall) of HCO+ lines in single dish observations of G286 is actually caused by gas emission from the two sub-clumps rather than gas infall. We advise great caution in interpreting gas kinematics (e.g. infall) from line profiles towards distant massive clumps in single dish observations. Energetic outflows are identified in G286 but the outflows are not strong enough to drive expansion of the two sub-clumps. The two parts of the ‘L’ type filament (‘NW–SE’ and ‘NE–SW’ filaments) show prominent velocity gradients perpendicular to their major axes, indicating that they are likely formed due to large-scale compression flows. We argue that the large-scale compression flows could be induced by the expansion of nearby giant H ii regions. The ‘NW–SE’ and ‘NE–SW’ filaments seem to be in collision, and a large amount of gas has been accumulated in the junction region where the most massive core G286c1 forms.
Protruding bullet heads indicating dark matter pull
Authors: Keshet Uri , Raveh Itay , Naor Yossi 
Published: September 2021

ABSTRACT
A clump moving through the intracluster medium of a galaxy cluster can drive a bow shock trailed by a bullet-like core. In some cases, such as in the prototypical Bullet cluster, X-rays show a gas bullet with a protruding head and pronounced shoulders. We point out that these features, while difficult to explain without dark matter (DM), naturally arise as the head of the slowed-down gas is gravitationally pulled forward toward its unhindered DM counterpart. X-ray imaging thus provides a unique, robust probe of the offset, collisionless DM, even without gravitational lensing or other auxiliary data. Numerical simulations and a toy model suggest that the effect is common in major mergers, is often associated with a small bullet-head radius of curvature, and may lead to distinct bullet morphologies, consistent with observations.
A general framework to test gravity using galaxy clusters IV: cluster and halo properties in DGP gravity
Authors: Mitchell Myles A , Hernández-Aguayo César , Arnold Christian , Li Baojiu 
Published: September 2021

ABSTRACT
We study and model the properties of galaxy clusters in the normal-branch Dvali–Gabadadze–Porrati (nDGP) model of gravity, which is representative of a wide class of theories that exhibit the Vainshtein screening mechanism. Using the first cosmological simulations that incorporate both full baryonic physics and nDGP, we find that, despite being efficiently screened within clusters, the fifth force can raise the temperature of the intracluster gas, affecting the scaling relations between the cluster mass and three observable mass proxies: the gas temperature, the Compton Y-parameter of the Sunyaev–Zel’dovich effect, and the X-ray analogue of the Y-parameter. Therefore, unless properly accounted for, this could lead to biased measurements of the cluster mass in tests that use cluster observations, such as cluster number counts, to probe gravity. Using a suite of dark-matter-only simulations, which span a wide range of box sizes and resolutions, and which feature very different strengths of the fifth force, we also calibrate general fitting formulae that can reproduce the nDGP halo concentration at percent accuracy for 0 ≤ z ≤ 1, and halo mass function with ${\lesssim}3{{\ \rm per\ cent}}$ accuracy at 0 ≤ z ≤ 1 (increasing to ${\lesssim}5{{\ \rm per\ cent}}$ for 1 ≤ z ≤ 2), over a halo mass range spanning four orders of magnitude. Our model for the concentration can be used for converting between halo mass overdensities and predicting statistics such as the non-linear matter power spectrum. The results of this work will form part of a framework for unbiased constraints of gravity using the data from ongoing and upcoming cluster surveys.
Learning about comets from the study of mass distributions and fluxes of meteoroid streams
Authors: Trigo-Rodríguez Josep M , Blum Jürgen 
Published: September 2021

ABSTRACT
Meteor physics can provide new clues about the size, structure, and density of cometary disintegration products, establishing a bridge between different research fields. From meteor magnitude data we have estimated the mass distribution of meteoroids from different cometary streams by using the relation between the luminosity and the mass obtained by Verniani. These mass distributions are in the range observed for dust particles released from comets 1P/Halley and 81P/Wild 2 as measured from spacecraft. From the derived mass distributions, we have integrated the incoming mass for the most significant meteor showers. By comparing the mass of the collected interplanetary dust particles (IDPs) with that derived for cometary meteoroids a gap of several orders of magnitude is encountered. The largest examples of fluffy particles are clusters of IDPs no larger than 100 μm in size (or 5 × 10–7 g in mass) while the largest cometary meteoroids are centimeter-sized objects. Such gaps can be explained by the fragmentation in the atmosphere of the original cometary particles. As an application of the mass distribution computations we describe the significance of the disruption of fragile comets in close approaches to Earth as a more efficient (and probably more frequent) way to deliver volatiles than direct impacts. We finally apply our model to quantify the flux of meteoroids from different meteoroid streams, and to describe the main physical processes contributing to the progressive decay of cometary meteoroids in the interplanetary medium.
First tidal disruption events discovered by SRG/eROSITA: X-ray/optical properties and X-ray luminosity function at z &lt; 0.6
Authors: Sazonov S , Gilfanov M , Medvedev P , Yao Y , Khorunzhev G , Semena A , Sunyaev R , Burenin R , Lyapin A , Meshcheryakov A , Uskov G , Zaznobin I , Postnov K A , Dodin A V , Belinski A A , Cherepashchuk A M , Eselevich M , Dodonov S N , Grokhovskaya A A , Kotov S S , Bikmaev I F , Zhuchkov R Ya , Gumerov R I , van Velzen S , Kulkarni S 
Published: September 2021

ABSTRACT
We present the first sample of tidal disruption events (TDEs) discovered during the SRG all-sky survey. These 13 events were selected among X-ray transients detected in the 0° &lt; l &lt; 180° hemisphere by eROSITA during its second sky survey (2020 June 10 to December 14) and confirmed by optical follow-up observations. The most distant event occurred at z = 0.581. One TDE continued to brighten at least 6 months. The X-ray spectra are consistent with nearly critical accretion on to black holes of a few ×103 to $10^8\, \mathrm{ M}_\odot$, although supercritical accretion is possibly taking place. In two TDEs, a spectral hardening is observed 6 months after the discovery. Four TDEs showed an optical brightening apart from the X-ray outburst. The other nine TDEs demonstrate no optical activity. All 13 TDEs are optically faint, with Lg/LX &lt; 0.3 (Lg and LX being the g band and 0.2–6 keV luminosity, respectively). We have constructed a TDE X-ray luminosity function, which can be fit by a power law with a slope of −0.6 ± 0.2, similar to the trend observed for optically selected TDEs. The total rate is estimated at (1.1 ± 0.5) × 10−5 TDEs per galaxy per year, an order of magnitude lower than inferred from optical studies. This suggests that X-ray bright events constitute a minority of TDEs, consistent with models predicting that X-rays can only be observed from directions close to the axis of a thick accretion disc formed from the stellar debris. Our TDE detection threshold can be lowered by a factor of ∼2, which should allow a detection of ∼700 TDEs by the end of the SRG survey.
metaGEM: reconstruction of genome scale metabolic models directly from metagenomes
Authors: Zorrilla Francisco , Buric Filip , Patil Kiran R , Zelezniak Aleksej 
Published: September 2021

AbstractMetagenomic analyses of microbial communities have revealed a large degree of interspecies and intraspecies genetic diversity through the reconstruction of metagenome assembled genomes (MAGs). Yet, metabolic modeling efforts mainly rely on reference genomes as the starting point for reconstruction and simulation of genome scale metabolic models (GEMs), neglecting the immense intra- and inter-species diversity present in microbial communities. Here, we present metaGEM (https://github.com/franciscozorrilla/metaGEM), an end-to-end pipeline enabling metabolic modeling of multi-species communities directly from metagenomes. The pipeline automates all steps from the extraction of context-specific prokaryotic GEMs from MAGs to community level flux balance analysis (FBA) simulations. To demonstrate the capabilities of metaGEM, we analyzed 483 samples spanning lab culture, human gut, plant-associated, soil, and ocean metagenomes, reconstructing over 14,000 GEMs. We show that GEMs reconstructed from metagenomes have fully represented metabolism comparable to isolated genomes. We demonstrate that metagenomic GEMs capture intraspecies metabolic diversity and identify potential differences in the progression of type 2 diabetes at the level of gut bacterial metabolic exchanges. Overall, metaGEM enables FBA-ready metabolic model reconstruction directly from metagenomes, provides a resource of metabolic models, and showcases community-level modeling of microbiomes associated with disease conditions allowing generation of mechanistic hypotheses.
STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells
Authors: Richart Laia , Lapi Eleonora , Pancaldi Vera , Cuenca-Ardura Mirabai , Pau Enrique Carrillo-de-Santa , Madrid-Mencía Miguel , Neyret-Kahn Hélène , Radvanyi François , Rodríguez Juan Antonio , Cuartero Yasmina , Serra François , Le Dily François , Valencia Alfonso , Marti-Renom Marc A , Real Francisco X 
Published: September 2021

Abstract
Cohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, we analyze the genomic distribution of STAG1 and STAG2 and perform STAG2 loss-of-function experiments using RT112 bladder cancer cells; we then analyze the genomic effects by integrating gene expression and chromatin interaction data. Functional compartmentalization exists between the cohesin complexes: cohesin-STAG2 displays a distinctive genomic distribution and mediates short and mid-ranged interactions that engage genes at higher frequency than those established by cohesin-STAG1. STAG2 knockdown results in down-regulation of the luminal urothelial signature and up-regulation of the basal transcriptional program, mirroring differences between STAG2-high and STAG2-low human bladder tumors. This is accompanied by rewiring of DNA contacts within topological domains, while compartments and domain boundaries remain refractive. Contacts lost upon depletion of STAG2 are assortative, preferentially occur within silent chromatin domains, and are associated with de-repression of lineage-specifying genes. Our findings indicate that STAG2 participates in the DNA looping that keeps the basal transcriptional program silent and thus sustains the luminal program. This mechanism may contribute to the tumor suppressor function of STAG2 in the urothelium.
Cisplatin fastens chromatin irreversibly even at a high chloride concentration
Authors: Moon Hyeon-Min , Park Jin-Sung , Lee Il-Buem , Kang Young-Im , Jung Hae Jun , An Dongju , Shin Yumi , Kim Min Ji , Kim Hugh I , Song Ji-Joon , Kim Jaehoon , Lee Nam-Kyung , Hong Seok-Cheol 
Published: September 2021

Abstract
Cisplatin is one of the most potent anti-cancer drugs developed so far. Recent studies highlighted several intriguing roles of histones in cisplatin's anti-cancer effect. Thus, the effect of nucleosome formation should be considered to give a better account of the anti-cancer effect of cisplatin. Here we investigated this important issue via single-molecule measurements. Surprisingly, the reduced activity of cisplatin under [NaCl] = 180 mM, corresponding to the total concentration of cellular ionic species, is still sufficient to impair the integrity of a nucleosome by retaining its condensed structure firmly, even against severe mechanical and chemical disturbances. Our finding suggests that such cisplatin-induced fastening of chromatin can inhibit nucleosome remodelling required for normal biological functions. The in vitro chromatin transcription assay indeed revealed that the transcription activity was effectively suppressed in the presence of cisplatin. Our direct physical measurements on cisplatin-nucleosome adducts suggest that the formation of such adducts be the key to the anti-cancer effect by cisplatin.
Transliteration of synthetic genetic enzymes
Authors: Wang Yajun , Liu Xiaolin , Shehabat Mouhamad , Chim Nicholas , Chaput John C 
Published: September 2021

Abstract
Functional nucleic acids lose activity when their sequence is prepared in the backbone architecture of a different genetic polymer. The only known exception to this rule is a subset of aptamers whose binding mechanism involves G-quadruplex formation. We refer to such examples as transliteration—a synthetic biology concept describing cases in which the phenotype of a nucleic acid molecule is retained when the genotype is written in a different genetic language. Here, we extend the concept of transliteration to include nucleic acid enzymes (XNAzymes) that mediate site-specific cleavage of an RNA substrate. We show that an in vitro selected 2′-fluoroarabino nucleic acid (FANA) enzyme retains catalytic activity when its sequence is prepared as α-l-threofuranosyl nucleic acid (TNA), and vice versa, a TNA enzyme that remains functional when its sequence is prepared as FANA. Structure probing with DMS supports the hypothesis that FANA and TNA enzymes having the same primary sequence can adopt similarly folded tertiary structures. These findings provide new insight into the sequence-structure-function paradigm governing biopolymer folding.
Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery
Authors: Wang Qian , Liu Jin , Janssen Josephine M , Tasca Francesca , Mei Hailiang , Gonçalves Manuel A F V 
Published: September 2021

Abstract
Prime editing is a recent precision genome editing modality whose versatility offers the prospect for a wide range of applications, including the development of targeted genetic therapies. Yet, an outstanding bottleneck for its optimization and use concerns the difficulty in delivering large prime editing complexes into cells. Here, we demonstrate that packaging prime editing constructs in adenoviral capsids overcomes this constrain resulting in robust genome editing in both transformed and non-transformed human cells with up to 90% efficiencies. Using this cell cycle-independent delivery platform, we found a direct correlation between prime editing activity and cellular replication and disclose that the proportions between accurate prime editing events and unwanted byproducts can be influenced by the target-cell context. Hence, adenovector particles permit the efficacious delivery and testing of prime editing reagents in human cells independently of their transformation and replication statuses. The herein integrated gene delivery and gene editing technologies are expected to aid investigating the potential and limitations of prime editing in numerous experimental settings and, eventually, in ex vivo or in vivo therapeutic contexts.
Adipose expression of miR-130b and miR-17-5p with wasting, cardiovascular event and mortality in advanced chronic kidney disease patients
Authors: Chan Gordon Chun-Kau , Than Win Hlaing , Kwan Bonnie Ching-Ha , Lai Ka-Bik , Chan Ronald Cheong-Kin , Ng Jack Kit-Chung , Chow Kai-Ming , Cheng Phyllis Mei-Shan , Law Man-Ching , Leung Chi-Bon , Li Philip Kam-Tao , Szeto Cheuk-Chun 
Published: September 2021

ABSTRACT

Background
There are limited data on the association of adipose microRNA expression with body composition and adverse clinical outcomes in patients with advanced chronic kidney disease (CKD). We aimed to evaluate the association of adipose miR-130b and miR-17-5p expressions with body composition, functional state, cardiovascular outcome and mortality in incident dialysis patients.

Methods
We performed a single-center prospective cohort study. Patients who were planned for peritoneal dialysis were recruited. miR-130b and miR-17-5p expressions were measured from subcutaneous and pre-peritoneal fat tissue obtained during peritoneal dialysis catheter insertion. Body composition and physical function were assessed by bioimpedance spectroscopy and Clinical Frailty Scale. Primary outcome was 2-year survival. Secondary outcomes were 2-year technique survival and major adverse cardiovascular event (MACE) rate.

Results
Adipose expression of miR-130b and miR-17-5p correlated with parameters of muscle mass including intracellular water (miR-130b: r = 0.191, P = 0.02; miR-17-5p: r = 0.211, P = 0.013) and lean tissue mass (miR-17-5p: r = 0.176, P = 0.04; miR-17-5p: r = 0.176, P = 0.004). miR-130b expression predicted frailty significantly (P = 0.017). Adipose miR-17-5p expression predicted 2-year all-cause survival (P = 0.020) and technique survival (P = 0.036), while miR-130b expression predicted incidence of MACE (P = 0.015).

Conclusions
Adipose miR-130b and miR-17-5p expressions correlated with body composition parameters, frailty, and predicted cardiovascular events and mortality in advanced CKD patients.
Zhentang Zhao: past and future of the Shanghai Synchrotron Radiation Facility
Authors: Zhao Weijie 
Published: September 2021

Abstract
A synchrotron light source is familiar to many researchers. Biologists use it to determine structures of proteins and other biomacromolecules; material scientists use it to analyze internal structures of different materials; physicists use it to explore the basic matter states; and physicians use it to perform medical imaging. A high-performance synchrotron light source is often the workhorse supporting a prosperous multi-disciplinary research center. In China, that is the Shanghai Synchrotron Radiation Facility (SSRF).
Since its opening to users in 2009, SSRF has bred many significant scientific achievements and laid the foundation for the Shanghai Zhangjiang Cluster of Big Science Facilities. On 3 August 2021, National Science Review (NSR) interviewed Professor Zhentang Zhao, Director of the SSRF Science Center and vice president of the Shanghai Advanced Research Institute, Chinese Academy of Sciences (CAS). Prof. Zhao introduced the construction and development of the synchrotron light source and X-ray free electron laser facilities in Shanghai, as well as how SSRF experiences may be valuable for big science facilities and centers now under construction in China.