bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cut-off Values of Triglycerides - Glucose Index for Metabolic Syndrome Associated with Type 2 Diabetes Mellitus
Authors: Hameed Ekhlas K. , Al-Ameri Laith T. , Hasan Hayder S. , Abdulqahar Zina H. 
Published: September 2021

The co-occurrence of metabolic syndrome with type 2 diabetes mellitus (T2DM) will potentiate the morbidity and mortality that may be associated with each case. Fasting triglycerides-glucose index (TyG index) has been recommended as a useful marker to predict metabolic syndrome. Our study aimed to introduce gender-specific cut-off values of triglycerides- glucose index for diagnosing metabolic syndrome associated with type 2 diabetes mellitus. The data were collected from Baghdad hospitals between May - December 2019. The number of eligible participants was 424. National cholesterol education program, Adult Treatment Panel III criteria were used to define metabolic syndrome. Measurement of fasting blood glucose, lipid profile, HbA1c level, blood pressure, and anthropometric were done and the triglyceride-glucose index was calculated. Ethical approval and informed consent were obtained .SPSS was used to analyze the data. Diabetic patients with metabolic syndrome showed an increased level of TyG Index. The prevalence of metabolic syndrome increased with increased TyG index quartiles. The TyG-Index showed significant correlations with all components of metabolic syndrome. The optimal cut-off value revealed 9.14, 9.28 for males and females respectively. In conclusion, TyG index is a good predictor of the presence of MetS in T2DM the TyG index, just measured in one laboratory test, is simple, informative and more suitable for the detection of metabolic syndrome in Iraqi type 2 diabetes mellitus.
Chloride Accumulation in Aboveground Biomass of Three Macrophytes (Phragmites Australis, Juncus Maritimus, and Typha Latifolia) Depending on Their Growth Stages and Salinity Exposure. Application for Cl- Removal and Phytodesalinization.
Authors: Delattre Emmanuel , TECHER Isabelle , Reneaud Benjamin , Verdoux Patrick , Laffont-Schwob Isabelle , Prohin Philippe 
Published: September 2021

Abstract
Anthropogenic activities can be the source of saline solid wastes that need to be treated to reduce their salt load to meet the purposes of reuse, valorization or storage. In this context, chloride remediation can be achieved using high-salt accumulating plants. However, there is very limited information on the comparative potential of different species in the same environment, and only scarce data concerning their efficiency as a function of growth stage. In order to rationalize these selection criteria, three macrophytes i.e. common reed (Phragmites australis), sea rush (Juncus maritimus) and cattail (Typha latifolia) were cultivated at two growth stages (6-months old and 1-year old) for 65 days in Cl- spiked substrates (from 0 up to 24 ‰ NaCl). The plants’ survival and potential capacity for removal of Cl- from substrates and accumulation in shoots were investigated. For the three studied species, mature and juvenile plants display a high tolerance to salinity. However, mature specimens with higher shoot biomass and Cl- contents are capable of greater chloride removal than juvenile plants. The sole exception is P. australis which displays just the same phytoremediation potential for both mature and juvenile specimens. Moreover, P. australis has the lowest potential when compared with other species, being 1.5 and 3 times lower than for J. maritimus and T. latifolia. When considering the plant growth and the shoot biomass production, chloride removal rates from the substrate point that mature J. maritimus should preferentially be used to design an operational chloride remediation system. The results highlight the relevance of considering the growth stage of plants used for Cl- removal.
Natural geometric unit system and electron magnetic moment anomaly
Authors: Kowalski Janusz "Jani" 
Published: September 2021

Abstract
Consequences of implementation of the natural geometric unit system (the SG) based on the pre-2019 SI system, in which four fundamental physical constants undergo joint numerical and dimensional normalization to unity c = G= k = h = 1, with only one base geometric unit u equal to √|h · G/c 3 | m, where the Newtonian gravitational constant G ≈ 6.673 655 205 · 10 -11 m3/(kg · s 2 ), are further explored. In addition to the earlier hypothesized simple electron mass to charge ratio formula me = e/(2 9πα), and formulas for stable quarks rest masses: quark u mu = √(⅔) / (2 7π √(πα)) u, equivalent of 2.360 MeV/c 2 and quark d md = √(⅓) -1 / (2 7π √(πα)) u, equivalent of 5.007 MeV/c 2 , a simple formula for electron magnetic moment anomaly is proposed α/2π - (α/2π) 2 - 2 8 (α/2π) 3 - 2 12 (α/2π) 4 - 2 16 (α/2π) 5 - 2 24 (α/2π) 6 ≈ 0.001 159 652 180. The finding supports the research area of purely geometric modelling of the fundamental physical forces and their unification. It seems plausible, that in the SG, with use of half integer powers of 2, 3, π and α only,all the fundamental properties of stable matter and electromagnetic radiation could be described
Dental pulp stem cells as a therapy for congenital entero-neuropathy
Authors: Yoshimaru Koichiro , Yamaza Takayoshi , Kajioka Shunichi , Sonoda Soichiro , Yanagi Yusuke , Matsuura Toshiharu , Yoshizumi Junko , Oda Yoshinao , Iwata Naoko , Takai Chiho , Nakayama Shinsuke , Taguchi Tomoaki 
Published: September 2021

Abstract
Hirschsprung’s disease (HSCR) and its allied disorders are congenital entero-neuropathies with life-long implications in many cases. Here we report the effects of intravenous transplantation of cultured dental pulp stem cells derived from deciduous teeth (dDPSCs) into ‘Japanese fancy-1’ (JF1) mice with entero-neuropathy caused by Ednrb mutation. Intravenously injected dDPSCs (multipotent neural crest cells with low immunogenicity) migrated to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Notably, transplanted dDPSCs differentiated into both enteric neurons and pacemaker interstitial cells to correct abnormalities in the electrical and mechanical activities of the proximal colon. dDPSC transplantation also led to repair of the small intestinal mucosa, changes in the gastrointestinal microbiota, improvements in nutritional status and prolongation of survival. We anticipate that dDPSC transplantation could be developed into a novel cell-based therapy for HSCR and its allied disorders.
Ultra-High Nonlinear Lead Silicate Photonic Crystal Fiber with Two Zero Dispersion for Supercontinuum Generation Applications
Authors: Gupta Pradeep Kumar , Akhouri Binay Prakash , Kumar Abhishek , Mishra Manoj , Singh Brajraj , Sharma Mohit 
Published: September 2021

Abstract
This paper presents a unique type of Lead silicate (SF57) photonic crystal fiber (PCF) with eleven rings of air holes. The PCF promises to yield very large nonlinearity ~13169 W −1 km −1 at 0.75 𝜇𝑚, ~8607 W^(-1) km^(-1) at 1.064 μm and ~4640 W^(-1) km^(-1) at 1.55 μm. The PCF has two zero dispersion at wavelength 0.3 μm and 1.50 μm . The value of nonlinearities is highest reported till now. The PCF contains very low optical mode field, causes large nonlinearity which makes it best suitable PCF for generating supercontinuum.
Ambulatory Blood Pressure Control Pattern in Hypertensive Patients at Tikur Anbesa Specialized Hospital: A Cross Sectional Study
Authors: ALEMAYEHU MULUALEM , Abebe Sintayehu , Yadeta Dejuma , Alemayehu Bekele 
Published: September 2021

Abstract
Background: Hypertension is the most common cardiovascular problem globally with a particularly increasing burden in developing countries like Ethiopia. Ambulatory blood pressure (ABPM) is superior to office blood pressure (OBP) measurement for diagnosing, prognosticating and following treatment efficacy for hypertension. There is no available data on ABPM control pattern in Ethiopians. This study will determine the ABPM control patterns in Ethiopian hypertensive patients on treatment. Material and Methods: This was a cross sectional study in hypertensive patients at Tikur Anbessa Specialized Hospitals outpatient departments carried out during January to May 2021. ABPM values of 244 consecutively sampled patients were analyzed. All patients had their BP monitored over 24 h with a Tonoport V (GE CS V6 71), and the data was interpreted using GE CardiosoftTM ABPM software in accordance with European Society of hypertension guidelines. Ethical clearance was given by Addis Ababa University Institutional Review Board and the study was conducted in compliance to standard ethical guidelines.Results: The study involved 244 adult hypertensive patients; mean age of the patients was 59.4years and, 54% were females. 58.6% of patients had controlled OBP, while only 45.1% had controlled ABPM. The mean OBP was 137 (19)/81 (10) mmHg and mean 24-hr ABP was 137 (16)/81 (10) mmHg; mean daytime BP was 136/79 ± 17/11 mmHg; mean night‑time BP, 138/84 ± 16/11 mmHg. Mean ABPM values were not significantly different between men and women. Comparison of ABPM values with OBP revealed high prevalence of the white coat effect (32%) and masked uncontrolled hypertension (46%). Presence of comorbidities particularly diabetes predicted poor ABPM control.Conclusion: More than half of patients had uncontrolled BP as per ABPM criteria and significant discrepancy exists between ABPM and OBP in assessing adequacy of BP control. Guiding management decisions using ABPM can improve BP control rates.
Genetic Evaluation and Screening of Diverse Wheat Genotypes for Spot Blotch Resistance
Authors: Roy Pritam , Gorai Shouvik , Bhattacharya Sudip , Murmu Mousumi , Hazra Soham , Mukherjee Subhra , Mukherjee Dhiman , Maji Anirban 
Published: September 2021

Abstract
Production of wheat (Triticum aestivum L.) the main food source of South Asian countries including India faces several constraints including spot blotch caused by Bipolaris sorokiniana resulting in yield loss of 25–43 % depending upon the stage of infection. Fifty genotypes were evaluated for nine quantitative characters and area under disease progress curve (AUDPC) to identify superior genotype with spot blotch resistance. High heritability coupled with moderate to high genetic advance as percent of mean was registered for grains per spike, tillers per square meter, days to 50% heading and days to 50% flowering indicating the characters to be governed by additive genes. Correlation and path coefficient analysis favored days to 50% heading, days to 50% flowering and grains per spike since they had significant positive correlation with yield and simultaneous negative correlation with AUDPC and also conferring highest positive direct effect towards yield. Multiple linear regression (MLR) analysis indicated days to 50% heading to be most sensitive with negative influence on AUDPC. D2 analysis grouped the 50 genotypes into 10 clusters suggesting presence of diversity among the genotypes. Frequency distribution of AUDPC among the genotypes showed more or less normal distribution of the character. Low AUDPC score with acceptable level of yield performance were recorded for the genotypes 29882, 29610, 29473, 29940, 29477, 29748 and 30081. Identification of high yielding and less susceptible genotypes for spot blotch disease in the present investigation offered an opportunity for wheat improvement through selective breeding.
Khat Chewing and Relapse in Peoples With Serious Mental Illness At Amanuel Mental Specialized Hospital: Comparative Study
Authors: Habte Fikreselam , Kassaw Chalelgn , Gedamu Melak , Asfaw Getachew , Abebaw Dessie , Haile Kibrom , Tulu Mikiyas 
Published: September 2021

Abstract
Background

people with serious mental illness using illicit drug exhibit poorer outcomes. But until now little is known about the impact of khat in thiss patient group. This study tried to assess the effect of khat chewing on relapse in people with serious mental illness.
Method

This is cross sectional comparative study involving 405 khat chewers and 400 non chewer people with serious mental illness. The study took three month involving interview (patient and care giver) and chart review. The study used Oslo Social Support Scale; Alcohol, Smoking, Substance Involvement Screening Test and questionnaire which include sociodemographic characteristics, illness related factors and relapse history.
Result

The study found that prevalence of relapse was higher in khat chewes than in non chewers (22% Vs 13%, p = 0.001) in people with serious mental illness. Additionally, the prevalence of relapse was also increased as the risk from use of khat was increased. In the khat chewer group previous hospitalization histories and presence of stressful life situation were the factor associated with relapse. On the otherhand treatment interruption, sleep disorder and previous hospitalization were the factors associated with relapse in non khat chewer people with serious mental illness.
Conclusion

Khat chewing poses additional burden for the already debilitating disease. Patient care should consider khat chewing as one of the components for intervention.
A Comprehensive Physiologically Based Pharmacokinetic (PBPK) Model for Nicotine in Humans Including Deposition and Diffusion in the Buccal and Respiratory Tissues from Using Different Nicotine-Containing Products with Different Routes of Exposure
Authors: Rostami Ali , Campbell Jerry , Pithawalla Yezdi , Pourhashem Hamideh , Muhammad-Kah Raheema , Sarkar Mohamadi , Liu Jianmin , McKinney Willie , Gentry Robinan , Gogova Maria 
Published: September 2021

Abstract
Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a previously published PBPK model to simulate a nicotine PK profile, following single or multiple use of various tobacco products (cigarettes, smokeless tobacco, and electronic nicotine delivery systems, or a nicotine inhaler (Nicotrol®). The uptake route in the model was designed to allow for three uptake compartments: buccal cavity (BC), upper respiratory tract (URT) (conducting and transitional airways) and lower respiratory tract (alveolar region). Within each region, the model includes product-specific descriptions of the flux of nicotine into plasma, as well as the flux of nicotine from the BC and URT to the gastrointestinal tract. These descriptions are based on regional deposition and diffusion models of nicotine into plasma, which depends on the product type. Regional deposition flux combined with regional differences in physiological parameters (e.g., blood perfusion ratio and tissue thickness) play a key role in the product-specific PK profile of nicotine. The current model describes the slower flux of nicotine into plasma across the BC and URT, as well as the rapid flux known to occur in the alveolar region. Overall, the addition of the BC and respiratory tract compartments to the nicotine model provided simulation results that are comparable to the nicotine time-course plasma concentrations reported from clinical studies for the four product categories simulated.
Holmium laser-assisted laparoscopic partial cystectomy for bladder cancer: technical feasibility and outcome
Authors: Kim Kang Sup , Kim Sang Hoon , Cho Hyuk Jin , Sur Hong Jin , Choi Yong Sun 
Published: September 2021

Abstract
BackgroundIn selected patients with bladder cancer, partial cystectomy is an alternative treatment for bladder preservation with fair oncologic result. During partial cystectomy, tumor margin demarcation is difficult. Various methods were introduced, however, there is no standard for tumor margin demarcation. We aimed to introduce and provide our experience with holmium laser-assisted method with ten patients.MethodsFrom March 2016 and February 2019, patients who want partial cystectomy for bladder cancer were enrolled in this study. Inclusion criteria were stage T2 or T3 disease and tumor location restricted within the dome, and lateral, posterior side of the bladder were included. Transurethral holmium laser-assisted mucosal incision was made and deepened until perivesical fat. Minimal Safety margin for 5–10 mm were spared, and tumor removal was done laparoscopically.ResultsTen patients underwent holmium laser-assisted laparoscopic partial cystectomy. All procedures were done without complication. The tumor locations were laterally in seven patients, dome in two patients, and posterior wall in one patient. Pathologic examination of surgical margin showed no cancer cell involvement in all cases. There were no recurrences or metastases for 12 months follow up.ConclusionsHolmium laser-assisted laparoscopic partial cystectomy is effective and safe technique. To achieve precise and appropriate surgical margin during the laparoscopic partial cystectomy, holmium laser resection provides feasible and safe method that assists in bladder incision with minimal ureteral orifice involvement.Trial registrationRetrospectively registered.
Significance of TP53 Mutational Status-Associated Signature in the Progression and Prognosis of Endometrial Carcinoma
Authors: Zhao Wancheng , Bi Fangfang , Pan Xue 
Published: September 2021

Abstract
Background:TP53 mutations are associated with poor outcome for patients with endometrial carcinoma (EC). However, to date, there have been no studies focused on the construction of TP53 mutational status-associated signature in EC. In this study, we aim to conduct a TP53 mutation associated prognostic genes signature for EC.Methods: Hence, we explored the mutational landscape of TP53 in patients with EC based on the simple nucleotide variation data downloaded from The Cancer Genome Atlas (TCGA) database. Differential expression analysis and least absolute shrinkage and selection operator (LASSO)–Cox analysis was used to establish TP53 mutation associated prognostic genes signature. The overall survival rate between the high-risk and low-risk groups was compared by Kaplan-Meier (K-M) method. Results: We found that the TP53 mutation was associated with poor outcome, older age, lower BMI, and higher grade and stage of EC in patients. A TP53 mutational status-associated signature was established based on transcriptome profiling data. Moreover, the patients in TCGA database were categorized into high- and low-risk groups. Kaplan–Meier (K-M) analysis indicated that the patients in the high-risk group have poor survival outcome. Furthermore, receiver operating characteristic (ROC) curves confirmed the robust prognostic prediction efficiency of the TP53 mutational status-associated signature. Finally, the prognostic ability was successfully verified in the other two datasets from cBioPortal database as well as in 60 clinical specimens.Conclusion: In summary, our research constructed a powerful TP53 mutational status-associated signature that could be a potential novel prognostic biomarker and therapeutic target for EC.
Research on Carbon Productivity and It's Spatial Convergence of Steel Industry in China
Authors: Wang Xiping , Tang Rong 
Published: September 2021

Abstract
The Global-Malmquist-Luenberger (GML) index was applied to analyse the carbon productivity in steel industry (SICP) of 29 provinces in China from 2006 to 2017, and then the SICP was decomposed into technical efficiency change index (TC) and technical progress index (EC). On this basis, the spatial effect is introduced into the traditional convergence model to investigate the spatial convergence of SICP. The empirical results show that: (1) The overall carbon productivity of China's steel industry is at a relatively low level, showing a slow growth trend. (2) The average value of the GML index of SICP is higher than 1, showing obvious inter-provincial and regional heterogeneity. Compared with EC, TC is the leading factor that promotes the increase of SICP. (3) The spatial absolute and condition β convergence of SICP exist in the whole country and the three major regions, but the σ convergence feature is not significant. The addition of spatial factors speeds up the convergence trend, and the speed of spatial absolute β convergence is about 3 times that of the classical convergence model. At the same time, the conditional convergence rate is significantly faster than the absolute convergence, which is closely related to the differences in influencing factors such as the industrial structure, economic development level, human capital, energy consumption intensity, and R&D investment among regions. There is still much room for improvement in carbon productivity in China's steel industry, and investment in scientific research must be increased in order to achieve the upgrading of the industrial structure and technological innovation. The existence of spatial convergence requires strengthening the joint reorganization of steel enterprises between provinces and regions, making full use of the spatial spillover effects of production technology, and realizing regional green and coordinated development.
Indoor, outdoor and ICU Environment monitoring of COVID-19
Authors: Santos Nathalia Villa , Waked Dunia , Wicik Zofia , Gomes-Gouvêa Michele Soares , Pinho João Renato Rebello , Levin Anna Sara Shefferman , Ho Yeh-Li , Veras Mariana Matera 
Published: September 2021

Abstract
The disease caused by the SARS-CoV-2 virus, which originated in Wuhan, Hubei Province, China, in December 2019 spread rapidly, causing a high number of deaths worldwide. The difficult ability to contain the transmission of the disease raised doubts about the possible forms of contamination. Studies have shown an increase in new cases of the disease on days when the level of pollution was high, raising questions that pollutants may be carriers of the virus. In this study, we investigated the involvement of fine particulate matter (PM2.5) in virus loading in common circulation (indoor and outdoor) environments and in the intensive care unit (ICU) of a hospital. PM2.5 was collected from May to November 2020, and the collection time per day was 48 to 72 h. After collection, the material was stored at a temperature of -80°C until the moment of analysis. Our results demonstrated that SARS-CoV-2 can be found in fine particulate material (PM2.5), but there is an essential interference of temperature, humidity and UV rays in the preservation of viral RNA.