bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beverages Consumption and Oral Health in the Aging Population: A Systematic Review
Authors: Zupo Roberta , Castellana Fabio , De Nucci Sara , Dibello Vittorio , Lozupone Madia , Giannelli Gianluigi , De Pergola Giovanni , Panza Francesco , Sardone Rodolfo , Boeing Heiner 
Published: October 2021

Little study has yet been made of the effect of different beverages on oral health outcomes in the aging population. The purpose of this systematic review is to evaluate the association between different beverages, including alcohol intake, coffee, milk, tea, and sugary drinks, and a cluster of oral health outcomes, including periodontal disease, oral dysbiosis, and tooth loss in older adults. The literature was screened from the inception up to May 2021 using six different electronic databases. Two independent researchers assessed the eligibility of 1308 retrieved articles regarding inclusion criteria; only 12 fitted the eligibility requirements, representing 16 beverage entries. A minimum age of 60 was the inclusion criterion. No exclusion criteria were applied to outcomes assessment tools, recruiting facilities (hospital or community), general health status, country, and study type (longitudinal or cross-sectional). The consumption of alcoholic beverages was expressed as alcohol intake in all eligible studies, thereby replacing alcoholic beverages in the analysis. The quality of evidence was judged as moderate for alcohol and low or very low for beverages. In regard to oral health in the elderly, the review identified information on alcohol (56.25%), followed by coffee (18.75%), milk (12.50%), tea (6.25%), and sugary drinks (6.25%). Alcohol, sugary drinks, and coffee were found to be related to tooth loss. Periodontal disease was inversely related to coffee and milk, but fostered by alcohol consumption. In one article, tea but not coffee seemed to improve oral microbiota. In summary, alcohol seems to be a driver for tooth loss and periodontal disease in the aging population. However, more research is needed to gain a more solid knowledge in this research area.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, PROSPERO, Identifier: CRD42021256386.
Circulating Tumor Cells: A Promising Biomarker in the Management of Nasopharyngeal Carcinoma
Authors: Wu Jiangtao , Zhu Huijun , Gao Feifei , Wang Rensheng , Hu Kai 
Published: October 2021

Nasopharyngeal carcinoma (NPC) is a malignancy that arises from the mucosal epithelium of the nasopharynx, and its prognosis is relatively favorable. The 5-year overall survival rate in patients with locally advanced NPC currently exceeds 80%, but the development of individualized diagnosis and treatment at the molecular level is relatively lacking. Circulating tumor cells (CTCs) is the generic term for tumor cells that are present in the peripheral blood circulation. As a new biomarker with good clinical application prospects, the detection of CTCs has the advantages of being non-invasive, simple, and repeatable. By capturing and detecting CTCs in peripheral blood and monitoring the dynamic variation of its type and quantity, we can assess the biological characteristics of tumor in a timely manner and evaluate the therapeutic effect and prognosis of patients in advance, which will help to develop individualized treatments of tumors. The primary purposes of this review were the clinical application of CTCs in tumor stage determination, treatment efficacy evaluation, and prognosis prediction of NPC. In addition, we estimated the correlation between Epstein-Barr virus infection and CTCs and analyzed the difference in karyotypes and specific markers expressed on CTCs. We believe that our study will provide new insights and biomarkers for the individualized treatment of patients with NPC.
Deep Learning-Based Computer-Aided Detection System for Automated Treatment Response Assessment of Brain Metastases on 3D MRI
Authors: Cho Jungheum , Kim Young Jae , Sunwoo Leonard , Lee Gi Pyo , Nguyen Toan Quang , Cho Se Jin , Baik Sung Hyun , Bae Yun Jung , Choi Byung Se , Jung Cheolkyu , Sohn Chul-Ho , Han Jung-Ho , Kim Chae-Yong , Kim Kwang Gi , Kim Jae Hyoung 
Published: October 2021

BackgroundAlthough accurate treatment response assessment for brain metastases (BMs) is crucial, it is highly labor intensive. This retrospective study aimed to develop a computer-aided detection (CAD) system for automated BM detection and treatment response evaluation using deep learning.MethodsWe included 214 consecutive MRI examinations of 147 patients with BM obtained between January 2015 and August 2016. These were divided into the training (174 MR images from 127 patients) and test datasets according to temporal separation (temporal test set #1; 40 MR images from 20 patients). For external validation, 24 patients with BM and 11 patients without BM from other institutions were included (geographic test set). In addition, we included 12 MRIs from BM patients obtained between August 2017 and March 2020 (temporal test set #2). Detection sensitivity, dice similarity coefficient (DSC) for segmentation, and agreements in one-dimensional and volumetric Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) criteria between CAD and radiologists were assessed.ResultsIn the temporal test set #1, the sensitivity was 75.1% (95% confidence interval [CI]: 69.6%, 79.9%), mean DSC was 0.69 ± 0.22, and false-positive (FP) rate per scan was 0.8 for BM ≥ 5 mm. Agreements in the RANO-BM criteria were moderate (κ, 0.52) and substantial (κ, 0.68) for one-dimensional and volumetric, respectively. In the geographic test set, sensitivity was 87.7% (95% CI: 77.2%, 94.5%), mean DSC was 0.68 ± 0.20, and FP rate per scan was 1.9 for BM ≥ 5 mm. In the temporal test set #2, sensitivity was 94.7% (95% CI: 74.0%, 99.9%), mean DSC was 0.82 ± 0.20, and FP per scan was 0.5 (6/12) for BM ≥ 5 mm.ConclusionsOur CAD showed potential for automated treatment response assessment of BM ≥ 5 mm.
The Asthma Family Tree: Evaluating Associations Between Childhood, Parental, and Grandparental Asthma in Seven Chinese Cities
Authors: Yu Hongyao , Su Fan , Wang Le-Bing , Hemminki Kari , Dharmage Shyamali C. , Bowatte Gayan , Bui Dinh , Qian Zhengmin , Vaughn Michael G. , Aaron Hannah E. , Xiong Shimin , Shen Xubo , Zhou Yuanzhong , Zhou Peien , Zeng Xiao-Wen , Chen Gongbo , Yang Bo-Yi , Hu Li-Wen , Dong Guang-Hui 
Published: October 2021

Objective:To evaluate the associations between childhood, parental, and grandparental asthma.Methods:We studied 59,484 children randomly selected from 94 kindergartens, elementary, and middle schools in seven Chinese cities from 2012 to 2013, using a cross-sectional survey-based study design. Information on their and their family members' (parents, paternal grandparents, and maternal grandparents) asthma status were reported by children's parents or guardians. Mixed effects logistic regressions were used to assess hereditary patterns of asthma and mediation analysis was performed to estimate the potential mediation effect of parents on the association between grandparental asthma and childhood asthma.Results:The magnitude of ORs for childhood asthma increased as the number of family members affected by asthma increased. Among children who had one family member with asthma, childhood asthma was associated with asthma in maternal grandmothers (OR: 2.08, 95% CI: 1.67–2.59), maternal grandfathers (OR: 2.08, 95% CI: 1.71–2.53), paternal grandmothers (OR: 2.40, 95% CI: 1.93–2.99), and paternal grandfathers (OR: 2.59, 95% CI: 2.14–3.13). Among children who had two family members with asthma, the highest asthma risk was found when both parents had asthma (OR: 15.92, 95% CI: 4.66–54.45). Parents had a small proportion of mediation effect (9–12%) on the association between grandparental asthma and childhood asthma.Conclusions:Grandparents with asthma were associated with childhood asthma and parents with asthma partially mediated the association.
Skeletal Muscle Adaptations to Exercise Training in Young and Aged Horses
Authors: Latham Christine M. , Owen Randi N. , Dickson Emily C. , Guy Chloey P. , White-Springer Sarah H. 
Published: October 2021

In aged humans, low-intensity exercise increases mitochondrial density, function and oxidative capacity, decreases the prevalence of hybrid fibers, and increases lean muscle mass, but these adaptations have not been studied in aged horses. Effects of age and exercise training on muscle fiber type and size, satellite cell abundance, and mitochondrial volume density (citrate synthase activity; CS), function (cytochrome c oxidase activity; CCO), and integrative (per mg tissue) and intrinsic (per unit CS) oxidative capacities were evaluated in skeletal muscle from aged (n = 9; 22 ± 5 yr) and yearling (n = 8; 9.7 ± 0.7 mo) horses. Muscle was collected from the gluteus medius (GM) and triceps brachii at wk 0, 8, and 12 of exercise training. Data were analyzed using linear models with age, training, muscle, and all interactions as fixed effects. At wk 0, aged horses exhibited a lower percentage of type IIx (p = 0.0006) and greater percentage of hybrid IIa/x fibers (p = 0.002) in the GM, less satellite cells per type II fiber (p = 0.03), lesser integrative and intrinsic (p≤ 0.04) CCO activities, lesser integrative oxidative phosphorylation capacity with complex I (PCI; p = 0.02) and maximal electron transfer system capacity (ECI+II; p = 0.06), and greater intrinsic PCI, ECI+II, and electron transfer system capacity with complex II (ECII; p≤ 0.05) than young horses. The percentage of type IIx fibers increased (p &lt; 0.0001) and of type IIa/x fibers decreased (p = 0.001) in the GM, and the number of satellite cells per type II fiber increased (p = 0.0006) in aged horses following exercise training. Conversely, the percentage of type IIa/x fibers increased (p ≤ 0.01) and of type IIx fibers decreased (p ≤ 0.002) in young horses. Integrative maximal oxidative capacity (p ≤ 0.02), ECI+II (p ≤ 0.07), and ECII (p = 0.0003) increased for both age groups from wk 0 to 12. Following exercise training, aged horses had a greater percentage of IIx (p ≤ 0.002) and lesser percentage of IIa/x fibers (p ≤ 0.07), and more satellite cells per type II fiber (p = 0.08) than young horses, but sustained lesser integrative and intrinsic CCO activities (p≤ 0.04) and greater intrinsic PCI, ECI+II, and ECII (p≤ 0.05). Exercise improved mitochondrial measures in young and aged horses; however, aged horses showed impaired mitochondrial function and differences in adaptation to exercise training.
HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
Authors: Liest Sara , Riishede Christiansen Iben , Prætorius Lisbeth , Bogstad Jeanette , Freiesleben Nina la Cour , Pinborg Anja , Løssl Kristine 
Published: October 2021

Background: Failed gonadotropin-releasing hormone (GnRH) agonist trigger with no oocyte retrieved during aspiration of several follicles is a rare but recurrent situation that can be rescued by the termination of the aspiration procedure, retriggering by human chorion gonadotropin (hCG), and repeated oocyte pickup 36 h later. Failed GnRH agonist trigger is frustrating and unsatisfactory, and fertility doctors must be aware of possible hCG retriggering and retained opportunity for successful cycle outcome.Objective: In this case report, we present a woman who experienced failed GnRH agonist trigger and rescue hCG retrigger followed by two consecutive live births after frozen-thawed single blastocyst transfers.Methods: A case report.Results: Two healthy children were born in 2018 and 2020, respectively as a result of controlled ovarian stimulation for IVF, failed GnRH agonist trigger followed by hCG re-trigger, and successful retrieval of 25 oocytes.Conclusion: Retriggering with hCG after failed GnRH agonist trigger can result in consecutive live births, and such knowledge can prevent cycle cancellation and patient discouragement. Knowledge on retriggering with hCG and consecutive live births after failed GnRH agonist trigger can prevent cycle cancellation and patient discouragement.
Subnational Purchasing Power Parities as a Tool for the Interarea Comparison
Authors: Kosarev A. E. 
Published: October 2021

The author describes the key characteristics of domestic and foreign experience in the development of conceptual and methodological foundations for the construction of subnational purchasing power parities. The relevance of the topic is explained, in particular, by the fact that subnational purchasing power parities are one of the key tools of the interarea comparison analysis. This causes the expanding attention paid by the national statistical ofces to its compilation and the development of the corresponding methodology. Thus, in July 2021, the World Bank as the Global ICP coordinator published two important guides presenting the international standards for producing purchasing power parities – for developing subnational PPPs and for integrating PPPs and CPI production activities.The international standards recommend considering the sum of expenditures on fnal consumption and gross fxed capital formation as the aggregated regional indicator in interarea PPP-based comparisons. A narrower indicator – household fnal consumption – can also be used depending on the purposes of further analysis; household budget survey data provide weights in comparing the consumer prices. Producing subnational PPPs is closely linked with assessing the spatial adjustment factors, which can provide an important tool in computing the national PPPs.Bearing in mind that producing subnational PPPs is a labor-intensive process, which includes all work stages (price data collection and validation, forming the weights system, computations, ensuring a balanced presentation of regions), the international standards suggest focusing on the annual frequency of works.Integrating the production of subnational PPPs with the CPI calculations system is one of the key factors for ensuring the efciency of the whole work.
Unsur Intrinsik Kumpulan Cerpen Ketika Bismillah Menjadi Alhamdulilah Karya Dalman dkk. Sebagai Bahan Ajar di SMA
Authors: Hesti Hesti , Verlinda Desnia 
Published: October 2021

Penelitian ini bertujuan untuk menjabarkan unsur intrinsik pada kumpulan Cerpen Ketika Bismillah menjadi Alhamdulilah karya Dalman, dkk. serta untuk mengetahui apakah cerpen yang dianalisis tersebut dapat dijadikan alternatif bahan ajar pada SMA kelas XI Tahun Ajaran 2017/2018. Penelitian ini menggunakan metode kualitatif deskriptif. Sedangkan teknik pengumpulan data yang digunakan adalah observasi, tes, dan menyebarkan angket. Cerpen Antara Cinta dan Cita-cita, Brevet untuk Mak, dan Davina dan Universitas Impian merupakan sumber data yang digunakan dalam penelitian ini. Dari penelitian ini diperoleh hasil; unsur instrinsik dalam cerpen berupa alur, tokoh/penokohan dan latar. Semua unsur tersebut berdasarkan pada silabus Mata Pelajaran Bahasa Indonesia kelas XI semester dua, yakni mengapresiasi atau menganalisis karya sastra cerpen. Data yang diperoleh, ketiga cerpen ini layak dijadikan alternatif bahan ajar pada siswa SMA. Hal ini mengacu pada teori pemilihan bahan ajar yakni; dari sudut bahasa, latar belakang budaya, dan psikologi. Kata Kunci: Cerpen, bahan ajar sastra, intrinsik.
KORELASI MULTIVARIATE BRAND TRUST DENGAN PURCHASE INTENTION KONSUMEN GREEN TEA DI FOOD COURT GIANT HYPERMART, WARU SIDOARJO
Authors: Poernomo Tri Tjahjo 
Published: October 2021

Abstrak Artikel penelitian ini bertujuan untuk mengukur kedekatan hubungan multivariat kepercayaan merek (dimensi viabilitas & dimensi intensionalitas) dengan niat beli. Sampel penelitian terdiri dari 60 partisipan pengkonsumsi minuman green tea di food court, giant hypermart waru melalui pendekatan judgement sample (Cooper & Emory, 2013). Parameter dimensi intensionalitas (x2) memiliki koef.r-partial dominan (13,4%), dibandingkan dengan parameter dimensi viabilitas (x1) yang memiliki koef.r-partial (1%). Model hottelings memiliki kontribusi koef.r-canonical dominan (124,7%) terhadap dua model lainnya (55,49%), (44,50%). Disimpulkan terdapat kepositipan keeratan hubungan yang cukup kuat antara parameter brand trust dan parameter purchase intention (74.4%). Selaras dengan penelitian Fang, Chiu & Wang, (2011) yang mengungkapkan bahwa terdapat hubungan positif antara brand trust dan purchase intention. H1 dan H2 penelitian dapat diterima faktualitasnya
A reproducible systematic map of research on the illusory truth effect
Authors: Henderson Emma L. , Westwood Samuel J. , Simons Daniel J. 
Published: October 2021

AbstractPeople believe information more if they have encountered it before, a finding known as the illusory truth effect. But what is the evidence for the generality and pervasiveness of the illusory truth effect? Our preregistered systematic map describes the existing knowledge base and objectively assesses the quality, completeness and interpretability of the evidence provided by empirical studies in the literature. A systematic search of 16 bibliographic and grey literature databases identified 93 reports with a total of 181 eligible studies. All studies were conducted at Western universities, and most used convenience samples. Most studies used verbatim repetition of trivia statements in a single testing session with a minimal delay between exposure and test. The exposure tasks, filler tasks and truth measures varied substantially across studies, with no standardisation of materials or procedures. Many reports lacked transparency, both in terms of open science practices and reporting of descriptive statistics and exclusions. Systematic mapping resulted in a searchable database of illusory truth effect studies (https://osf.io/37xma/). Key limitations of the current literature include the need for greater diversity of materials as stimuli (e.g., political or health contents), more participants from non-Western countries, studies examining effects of multiple repetitions and longer intersession intervals, and closer examination of the dependency of effects on the choice of exposure task and truth measure. These gaps could be investigated using carefully designed multi-lab studies. With a lack of external replications, preregistrations, data and code, verifying replicability and robustness is only possible for a small number of studies.
Idunn Mons: Evidence for Ongoing Volcano-tectonic Activity and Atmospheric Implications on Venus
Authors: D’Incecco P. , Filiberto J. , López I. , Gorinov D. A. , Komatsu G. 
Published: October 2021

Abstract
In 2010 the ESA Venus Express Visible and Infrared Thermal Imaging Spectrometer (VIRTIS) instrument first observed 1 μm emissivity anomalies over the top and eastern flank of Idunn Mons (46° S; 146° W), a 200 km wide volcano located in Imdr Regio, a volcano-dominated large volcanic rise of Venus. The anomalies suggest the presence of chemically unweathered and fresh volcanic deposits, which provided the first hint that volcanism in this area may have been active during the past few million years. Subsequent studies have investigated the geologic and atmospheric evolution at Idunn Mons, but no study has comprehensively investigated the evolution and the implication for recent activity in Idunn Mons. Previous work, using both VIRTIS data and Magellan radar emissivity data, confirmed the occurrence of unaltered basaltic lava flows at Idunn Mons. Building on that previous work, experimental laboratory studies have revealed that chemical weathering on Venus may act much faster than previously expected, which suggests very young ages for these flows. This inference has been supported by investigations of the tectonic fracturing surrounding Idunn Mons. Finally, atmospheric data from VIRTIS also show regional anomalies in the speed of the winds in the lower atmosphere over Imdr Regio, which may be related to very recent or ongoing volcanism. In this paper, we take a comprehensive approach, using atmospheric to surface measurements, including recent laboratory experiments, to constrain the evolution of Idunn Mons. Our work suggests that Idunn Mons may be geologically both volcanically and tectonically active today.
Croire à la lettre
Authors: Dunan-Page Anne , Prunier Clotilde 
Published: October 2021

Ce volume propose une réflexion sur les relations entre la religion et l’épistolarité en France et en Grande-Bretagne, aux xviie et xviiie siècles. Douze spécialistes de la période, en histoire, théologie et littérature, s’interrogent sur des correspon­dances officielles ou clandestines, spirituelles ou pastorales, pour présenter un panorama des rapports entre les correspondances manuscrites ou imprimées et l’orthodoxie ou les hétérodoxies. Outil de communication entre les croyants, les églises et les communautés, mais aussi entre les membres du clergé et les fidèles, la lettre, qu’elle soit ouverte ou secrète, qu’elle appelle une réponse ou le silence, qu’elle soit cachée, codée, interceptée, imprimée ou diffusée, qu’elle soit isolée ou fasse partie d’un corpus plus large, fut le principal moyen d’expression de la piété et du sentiment religieux dans des siècles marqués par de profonds bouleversements épistémologiques. Prises dans leur ensemble, ces contributions constituent la première tentative d’étude croisée du religieux et de l’épistolaire dans l’espace européen entre Réforme et Révolution.
Influencia de componentes de inteligencia emocional en rendimiento académico escolar: Análisis en una Institución Educativa en Perú
Authors: Lazo Juan Guillermo Lazo , De Oliveira Suely Noronha , Graf Annette Kaltenbrunner , Saavedra Blanca Josefina Vallejos 
Published: October 2021

En los últimos veinte años, el Ministerio de Educación de Perú viene aplicando y acompañando la medición de logros de aprendizaje de los estudiantes de la educación básica por medio de evaluaciones nacionales e internacionales a gran escala. Estos estudios están llevando no sólo a conocer las causas de los logros de aprendizaje, sino al de tratar de revertir alguna situación no deseada. La investigación, en proceso, en la cual se basa este artículo, tiene como objetivo identificar de qué manera la inteligencia emocional influye en el rendimiento académico de estudiantes de nivel secundario de una institución educativa en Lima, Perú. Esta investigación fue orientada por la metodología cuantitativa y se utilizó de métodos estadísticos para inferir las relaciones entre la inteligencia emocional y el rendimiento académico de los alumnos en cada área curricular, a través de datos obtenidos por el test BarOn ICE: NA, y las calificaciones de los alumnos. Los resultados comprobaron la relación existente entre la inteligencia emocional y el desempeño escolar, mostrando que los componentes de la inteligencia emocional varían según el área curricular específica.

In the last twenty years, the Peruvian Ministry of Education has been implementing and accompanying the measurement of learning achievements of students in basic education through large-scale national and international assessments. These studies are leading not only to know the causes of learning achievement, but to try to reverse some unwanted situation. The research, in process, on which this article is based, aims to identify how emotional intelligence influences the academic performance of secondary school students in an educational institution in Lima, Peru. This research was guided by the quantitative methodology and was used statistical methods to infer the relationships between emotional intelligence and academic performance of students in each curricular area, through data obtained by the BarOn ICE: NA test, and the qualifications of the students. The results verified the relationship between emotional intelligence and school performance, showing that the components of emotional intelligence vary according to the specific curricular area.