bluuebunny/crossref_metadata_2025_split huggingface dataset:
Klebsiella pneumoniae pathogenicity in silk moth larvae infection model
Authors: Tuba Tasnia , Chowdhury Farhan R , Hossain Tasnia , Farzana Maisha , Ahad Inteshar Ibn , Hossain M Mahtab , Hossain M Ismail , Saleh Nusrat U A , Nawaar Nafisa , Uddin M Aftab , Bari M Latiful , Hossain Muktadir S 
Published: December 2021

Abstract
The emergence of antibiotic resistant bacteria is a major health concern worldwide in recent years. The objective of this study is to establish the larvae of the silk moth (commonly known as silkworm), Bombyx mori as an infection model to study antibacterial effect of antibiotics against Klebsiella pneumoniae. In this study, the pathogenicity of a K. pneumoniae strain isolated from food to silkworm larvae was examined. Within 72h of bacterial injection, all silkworm larvae were killed in a dose-dependent manner with their body color turning into black due to increased melanization. Bacterial numbers in the larval hemolymph (blood) significantly increased after 9h of infection with a decrease in viable circulatory hemocytes in hemolymph. When presented with bacteria laden leaves, larvae did not eat but injection of bacteria directly into the midgut killed larvae within 12h with a higher load required in comparison to that required for the killing by hemolymph injection. Administration of four different antibiotics into larval hemolymph showed therapeutic effect at different doses with varying efficacies against hemolymph-injected K. pneumoniae. These results indicate that the silkworm larvae can be used as an infection model not only to study the pathogenicity of K. pneumoniae but also to perform rapid screening for the identification of antibiotics effective against multidrug-resistant strains of K. pneumoniae.
A Simulation Model for Geriatric Education: Theory, Virtual Transformation and Quality Improvement
Authors: Drost Jennifer , Fosnight Susan 
Published: December 2021

Abstract
Delivery of effective healthcare for the geriatric population is often complex due to the interplay between physical, social, and emotional variables. It is well established that it is the interplay between chronic medical conditions, social determinants of health, function and geriatric syndromes that drives outcomes. This complexity makes it especially important for the healthcare team to take an interprofessional team approach to avoid fragmented care which can lead to patient dissatisfaction, an ineffective plan of care, and low-quality outcomes. However, effective teamwork is not innate to healthcare; it must be learned and developed over time through purposeful education. The literature on team training supports active learning pedagogies such as simulation-based education that has emerged as an effective way to translate teamwork education into practice. Participation in active learning such as simulation, provides learners with authentic experiences that become cognitive frames that can transition into real practice. Education of adult learners should be a scaffolding of experiences that build on one another. This approach can lead the learner from the acquisition of basic knowledge, skills, and attitudes, to higher levels of competency and clinical judgement. Simulation simultaneously engages cognitive, perceptual-motor, and affective learning, and when combined with effective debriefing can lead to higher levels of learning. Effective models with scaffolding of experiences using simulations for geriatric team training are lacking in the literature. We describe here the theoretical framework for such training, adaptions of in-person and virtual training models due to COVID-19 restrictions through rapid cycle quality improvement.
Advancing Dementia Care Interventions With Technology Solutions
Authors: Cho Jinmyoung , Fazio Elena 
Published: December 2021

Abstract
Over the past two decades, a number of interventions have been developed and tested to help meet the complex care needs of persons living with dementia (PLWD) and the family care support system. Despite the large foundation of empirical evidence, they are often not readily available as part of dementia care support services. Interventions leveraging technology-based solutions have the potential to bolster their desirability, efficacy, and feasibility. While progress has been made, there is still a need to design and test new innovative solutions in real-world settings. This symposium will highlight three such innovative technology solutions for dementia care and explore lessons learned in their development and testing. Smith et al. demonstrate the feasibility of using a novel in-situ sensor system to assess daily functions for PLWD in home or assisted care settings. Results of detecting and classifying diverse forms of functional assessment and environmental conditions will be discussed in the presentation. Czaja et al. describe a randomized controlled trial evaluating the feasibility and efficacy of an innovative dyadic intervention (DT) delivered through an interactive technology. Recruitment challenges and lessons learned from the feasibility of implementing a dyadic intervention will be presented. Stevens et al. introduce an online approach to delivering REACH II, GamePlan4Care (GP4C). Qualitative thematic analyses from GP4C user test sessions related to both the content and technical features will be discussed. Discussant Dr. Elena Fazio will address the role of technology solutions as a strategy within dementia care interventions and unique challenges and contributions of each project.
An Exploration on Trust
Authors: Portacolone Elena 
Published: December 2021

Abstract
“Trust is a form of love,” explained a study participant. As a form of love, trust nourishes connections and accelerates progress. As a result, the purpose of this session is to reflect upon the notion of trust and examine how trust moves science and social justice forward. Trust must be seen as sustained or broken over multiple generations. Moreover, trust between older adults and medical and social support institutions has profound implications for this historical moment. In the COVID-19 pandemic, trust can be viewed as a facilitator of emergency responses in the State of Washington as noted in Dr. Berridge’s paper. On the other hand, distrust and a related sense of abandonment contributes to Black Americans' limited uptake of COVID-19 vaccinations, as noted in Dr. Johnson’s work. On a related note, Dr. Perry’s work shows that lack of trust over time has led those aging with hemophilia to withdraw from care at different points in their own trajectories. Finally, on a positive note, Dr. Kotwal’s work illustrates the role of a peer outreach intervention in facilitating trusting relationships among diverse, low-income older adults which led to sustained reductions, over a 2-year period, in loneliness, barriers to socializing, and depression. This symposium on trust highlights how researchers work, either consciously or unconsciously, within a continuum of trust in their participants' communities. At a broader level, systemic attention to building trust from academia, government, and national advocacy organizations holds the potential to foster meaningful scientific engagement and empowerment of historically marginalized communities.
Description and Demo of the Best Practice Caregiving Database on 44 Research Proven Dementia Caregiving Programs
Authors: Bass David , Ciancibello Alyssa , Schaffer Rachel , Powers Sara 
Published: December 2021

Abstract
A major advance in family caregiving has been the development, testing, and community delivery of research-proven, evidence-based support programs for family or friend caregivers of persons living with dementia. This presentation showcases and demos Best Practice Caregiving (BPC), a new online resource with comprehensive profiles for 44 of the top evidence-based dementia caregiving programs that are ready for scaling in communities. For these 44 programs, BPC is a database that presents key research findings with links to all its published articles, comprehensive program descriptions including all implementation features, and survey data on program delivery experiences from 324 healthcare and community organizations that offered the program as a regular part of their service portfolio 2019. BPC enables professionals to make side-by-side comparisons of the 44 programs, with the goal of increasing implementations of these evidence-based programs by healthcare and community service organizations.
Outcome Priorities Among Evidence-Based Dementia Caregiving Programs: A Closer Look
Authors: Powers Sara , Ciancibello Alyssa , Schaffer Rachel , Bass David , Minyo Morgan 
Published: December 2021

Abstract
Currently, the Best Practice Caregiving website provides information on 231 published studies from 44 dementia caregiving evidence-based programs that have demonstrated beneficial outcomes for dementia caregivers within health care and community-based settings. Across all programs, a total of 34 biopsychosocial outcomes were identified. Supported by the commonly used stress-related frameworks (e.g., Stress-Health Process, Cognitive Behavioral Theory) for which the programs were developed, the most frequently utilized program outcomes included: 1) Caregiver stress, strain, and/or burden (84.1%); 2) Caregiver depressive symptomology (79.5%); and 3) Caregiving efficacy, skills, and/or confidence (63.6%). The least common programmatic outcomes included: 1) Access to support information/Community service use (9.1%); 2) Unmet needs (6.8%); and 3) Respite/break from care (2.3%). The lesser utilized outcomes provide critical insight into current evidence-based programmatic priorities and ways in which professionals can seek to fill gaps in dementia caregiving interventions. Discussion will also focus on future directions of caregiver-related outcome assessments.
Caring Beyond the Challenges: Grit in Dementia Family Caregivers
Authors: Blieszner Rosemary , Savla Jyoti , Roberto Karen , McCann Brandy , Hoyt Emily 
Published: December 2021

Abstract
Scholars and practitioners recognize the importance of family caregivers for persons with dementia (PwD) persevering through difficulties and remaining committed to providing care (i.e., possessing grit). Based on Pearlin’s stress process model, we examined how grit is associated with stressors and strains that interfere with caregiver well-being and jeopardize continued caregiving. The sample included 158 family caregivers of PwD from rural Appalachia. SEM analysis revealed that grit and family and friend affectual solidarity contributed significantly to mastery. Grit and family solidarity were associated indirectly with role overload through their effect on mastery. Results demonstrate the value of acknowledging the role of grit in enhancing caregivers’ confidence about managing difficulties they face and reducing their sense of being overwhelmed by caregiving responsibilities. Thus, strengthening dementia caregivers’ commitment to and perseverance in their role is crucial for sustaining their motivation to provide care, despite the challenges they face.
A Coordinated Analysis of the Associations Among Personality Traits, Cognitive Decline, and Dementia
Authors: Graham Eileen , Jackson Kathryn , James Bryan , Willroth Emily , Mroczek Daniel 
Published: December 2021

Abstract
There are considerable individual differences in the rates of cognitive decline across later adulthood. Personality traits are among the factors that may account for some of these differences. The current project investigated whether personality traits were associated with trajectories of cognitive decline, and whether the associations were different before and after dementia diagnosis. The data were analyzed using linear mixed effect regression models. Across study aims was a focus on replicability and generalizability. Each question was address in four independent longitudinal studies (EAS, MAP, ROS, SATSA), and then meta-analyzed using random effects meta-analysis, providing estimates of heterogeneity. As expected, we detected evidence for cognitive decline in all four samples. Results also indicated that neuroticism and openness were associated with total cognitive function. and openness was associated with decline post dementia diagnosis.
Exploring Perceptions of Age Friendliness Across Different Campus Constituent Groups
Authors: Beaulieu Celeste , Silverstein Nina , Bowen Lauren , Whitbourne Susan , Montepare Joann 
Published: December 2021

Abstract
College campuses are typically considered as environments for adults ages 18-24, even though campuses are comprised of faculty, staff, students, and lifelong learners of all ages. Each group may experience the campus environment differently due to their differing roles. Faculty, staff and students from 21 participating designated Age Friendly Universities across the country answered survey questions on age friendliness, AFU awareness, and on campus practice items. Crosstab analyses show that constituent groups are equally aware of their university as an AFU (6% of each group). Students perceived their university as more age friendly (M=3.47, SD=0.73) compared to faculty and staff, the latter having the lowest perceived friendliness (M=3.27, SD=0.63). Specific age friendly practices show that staff members had markedly different perceptions of the institution’s age friendly practices. AFUs need to consider higher education environments as workplaces as well as learning centers to make policies age friendly for all groups.
Creative Hobbies as a Protective Factor Against Stress During the COVID-19 Pandemic in Older Adults
Authors: Israel Sarah , Mackenstadt Darby , Adams-Price Carolyn 
Published: December 2021

Abstract
The COVID-19 pandemic dramatically impacted our way of life, leading to increased rates of anxiety and depression (Panchal et al., 2021). The implications may be worse for older adults who account for 80% of all COVID deaths (Freed et al., 2020). Meanwhile, prior to the pandemic, Adams-Price and colleagues (2018) found that creative hobby participation provided slightly different benefits for middle-aged and older adults. Specifically, evidence suggested that middle-aged adults may use their creative hobby more for stress relief than older adults. Using a sample of 239 women, aged 40 to 84 years old (M = 59.7), we examined whether the degree to which viewing one’s creative hobby as a component of one’s identity related to perceived stress, health anxiety, and depressive symptoms. In addition, we wanted to know whether these relationships were moderated by age. Single moderation models suggest that viewing one’s creative hobby as a part of their identity was related to higher health anxiety and reporting more depressive symptoms. In addition, age was related to reporting lower perceived stress, health anxiety, and depressive symptoms. Lastly, age provided a significant moderation effect to the relationship between degree of identity associated with one’s creative hobby and perceived stress such that middle-aged adults with a high degree of identification with their creative hobby reported the most perceived stress while older adults with a high degree of identification with their creative hobby reported the least perceived stress. Implications for older adult’s well-being and adaptiveness to the COVID-19 pandemic will be discussed.
Age Differences in Becoming COVID Long-Haulers and in Post-Acute Sequelae of SARS-CoV-2
Authors: Wu Qiao , Crimmins Eileen 
Published: December 2021

Abstract
People who have had COVID-19 can suffer from the continuation of Post-Acute Sequelae of SARS-CoV-2 (PASC), also known as “long COVID”, for months after infection. Understanding PASC is important for treatment, care, and projecting future health of the population. Since older adults are at higher risk of severe illness and consequences from COVID, we hypothesize that they are more likely to become COVID long-haulers and report more symptoms at the time of diagnosis and three months after. We use a nationally representative sample of adults from the Understanding America Study COVID-19 Survey, from March to December 2020, to estimate the prevalence of long COVID and identify the most common long-term symptoms and how they vary by age. We use multilevel models to examine the determinants of symptom count and change over time. Among the 608 people with a COVID diagnosis, 83 (13.7%) aged over 65; almost half (47.9%) reported symptoms three months after diagnosis; the proportion did not differ across age groups. The most common symptoms were fatigue (25.0%), runny/stuffy nose (18.9%), body aches (16.4%), sneezing (15.1%), and headache (13.6%). These symptoms were consistent across age groups, while people aged 65 and older reported significantly less cough (χ2=3.96; P=0.05) and headache (χ2=4.24; P=0.04) compared to their younger counterparts. Neither the mean at the time of the diagnosis nor the rate of change of the symptom count varied across age groups. Our analyses suggest that age is not a significant determinant of PASC symptom count or becoming a COVID long-hauler.
COVID-19 Cases, Hospitalizations, and Deaths in Nursing Homes: Factors Impacting the Second Surge
Authors: Fleming Sean , Qato Danya , Wallem Alexandra , Kepczynska Paulina , Wastila Linda , Le Tham , Yang Jeanne 
Published: December 2021

Abstract
As of March 2021, over 128,000 nursing home (NH) residents have died due to COVID-19 complications, accounting for one-third of all U.S. COVID-19 deaths. Early studies highlighted factors which heightened residents’ risk—facility size and profit status, CMS Five-Star quality rating, race, and high Medicaid share. Despite improved nationwide social distancing and access to protective equipment, between October-December 2020 nursing home cases, hospitalizations, and deaths peaked to highest levels since the pandemic’s advent. The purpose of this study is to quantify previously unexamined associations between resident, facility, and geographic characteristics and COVID-19 infections, hospitalizations, and fatalities in nursing homes during this second surge. In this cross-sectional study, we constructed a novel dataset with linked facility- and county-level data from the CMS Nursing Home COVID-19 Public File, Nursing Home Compare, Long-Term Care Focus, and The New York Times. Multivariable logistic regression evaluated the odds of COVID-19 infections, hospitalizations, and deaths in nursing homes. Among 13,156 nursing homes, 80.5% reported ≥1 COVID-19 cases; on average, nursing homes reported 4.5 hospitalizations and 3.0 deaths. Facilities with higher acuity patients, chain status, &gt;150 beds, high percentage white residents, low Medicaid share, high surrounding county case rates, and occupancy rates &gt;75% were significantly (p &lt;.001) related to increased odds of all outcomes. N95 mask shortages continued to increase risk of cases and hospitalizations. Five-Star ratings, high influenza vaccination rates, and clinical staff shortages were not significant factors. Findings demonstrate that through 2020, nursing homes continued to face challenges protecting their residents from COVID-19-related morbidity and mortality.
More Negative Emodiversity Is Associated With Worse Mental Illness During (but Not Before) COVID-19
Authors: Urban-Wojcik Emily , Barnes Alexandra , Fitch Dan , Kirvin-Quamme Andrew , Nord Elizabeth , Gresham Lauren , Davidson Richard , Schaefer Stacey 
Published: December 2021

Abstract
Relations between negative emodiversity (NED; the variety and relative abundance of negative emotions) with depression and anxiety were examined before and during the COVID-19 pandemic. Forty-five individuals (ages 25-65) participated in two ecological momentary assessments (EMA): pre-pandemic and during-pandemic (Fall, 2020). Participants reported how much they felt 6 negative emotions several times each day for 10 days (resulting up to 91 EMA “events”). Each event’s NED was computed and then averaged using an adaptation of Shannon’s entropy. Participants with higher levels of average NED had higher levels of concurrent depression and anxiety. When adjusting for average levels of negative emotion and other covariates, NED was a significant predictor of depression and anxiety only during the pandemic. These findings, which did not vary by age, suggest that having more diverse negative emotions on a moment-to-moment basis may hold greater significance for mental illness outcomes during times of extreme chronic stress.
The Longitudinal Relationship Between Engagement in Various Activities and Cognitive Functioning
Authors: Jeon Sangha , Lee Soomi , Charles Susan 
Published: December 2021

Abstract
Recent studies indicate that engaging in more diverse activities is related to higher cognitive functioning. Questions remain, however, regarding whether activity variety within different domains is important. We examined how overall activity variety across domains, as well as variety within cognitive, physical, and social domains are related to cognitive functioning. Data were drawn from Waves 2-3 of Midlife Development in the United States (MIDUS). In cross-sectional analyses (N = 3349), activity variety overall and within each domain were positively related to cognitive functioning regardless of activity frequency. In longitudinal analyses (n = 2054), participants with consistently higher activity variety overall and within the social domain over time (vs. those with consistently low or decreasing activity variety) exhibited better cognitive functioning at W3 after adjusting for cognitive functioning at W2. Findings suggest that engaging in a variety of activities that involve multiple cognitive processes might be beneficial for cognitive health.
Variety in Positive Experience and Mental Health: Evidence From Two National Surveys of U.S. Adults
Authors: Ong Anthony , Lee Soomi 
Published: December 2021

Abstract
Scheduling of pleasant activities is a core treatment component for various psychiatric disorders, but little is known about whether variety in positive experiences is associated with improved mental health and well-being. Here we demonstrate the benefits of diverse positive experiences. Using data from the Midlife in the United States (MIDUS) II (N = 1,233, Mage = 57yrs) and Refresher (N = 855, Mage = 52yrs) cohorts, we show that greater variety of positive events is associated with lower depression and anxiety, and fewer visits to mental health professionals. These associations remained robust to differences in sociodemographics (age, gender, race, education), personality (openness, conscientiousness, extraversion, agreeableness, neuroticism), and the frequency of positive events, and the results replicated across the two cohorts. The findings highlight the importance of activity diversity in older adults and suggest that efforts to increase engagement in diverse positive experiences could have beneficial effects on mental health outcomes.