bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic and acquired blistering disorders of pediatric age group
Authors: Karmakar Subhrojyoti , Basu Keya , Sengupta Moumita , Chatterjee Gobinda , Sarkar Sumantra , Bandopadhyay Manimoy 
Published: July 2021

Introduction:
Blistering or vesiculobullous disorders in pediatric population are either immunobullous or mechanobullous. Spectrum was analyzed using demographic details, clinical features, histopathology, direct immunofluorescence (DIF) and Immunofluorescence mapping (IFM).

Methodology:
This was a single institution based observational study in children below 18 years. The demographic details were collected using proforma containing particulars of the patient, history, complaints, and other parameters. Punch biopsy of the skin lesion was done. Biopsy samples were examined under light microscope followed by DIF using fluorescent conjugated polyclonal antibody against immunoglobulins IgG, IgM, IgA, and complement C3. The salt-split technique was also used in particular cases. IFM was done using anticytokeratin (CK) 5 & 14, antilaminin 332, anticollagen VII, and anticollagen IV antibodies.

Results:
Out of total 50 cases, linear IgA bullous dermatosis (LABD) was the commonest. The average concordance between clinical and final diagnosis (histopathological examination + DIF) was 87.5% and discordance was 12.5%. The agreement between histopathological examination and DIF was found to be substantially significant (κ = 0.6892). IFM depicted epidermolysis bullosa simplex with reduced CK 14 expression, dystrophic epidermolysis bullosa with reduced Collagen VII expression and junctional epidermolysis bullosa with absent laminin 5 expression.

Conclusion:
The spectrum of bullous lesions in childhood was properly delineated and subcategorization of EB was done. Histopathological examination showed the hallmarks that were conclusive in most of the cases except in LABD and EB. DIF and IFM proved indispensable in those cases. Thus, DIF is not a substitute for histopathology but complementary to it.
PD-L1 Expression in colorectal carcinoma and its correlation with clinicopathological parameters, microsatellite instability and BRAF mutation
Authors: Srivastava Pallavi , Husain Nuzhat , Shukla Saumya , Chauhan Smita , Pandey Anshuman , Masood Shakeel 
Published: July 2021

Context:
Programmed cell death ligand-1 (PD-L1) is the key inhibitor of the cytotoxic immune response thus causing progression of tumors and adverse prognosis in many malignancies.

Objective:
The current study investigates PD-L1 expression in colorectal carcinoma and its correlation with clinicopathological parameters, microsatellite instability, and BRAF mutation

. Material and Methods:
110 cases of colorectal carcinoma were evaluated for PD-L1 expression using SP263 clone in tissue microarray. Clinico-pathological characteristics and survival data were correlated with PD-L1 expression analyzed at different cut-offs of ≥1%, ≥10% and ≥50% in tumor cells and tumor infiltrating lymphocytes along with its correlation with BRAF expression and microsatellite instability status in these cases.

Results:
Mean age was 49 years with male to female ratio of 1.5:1. 52.7% cases presented with stage 3/4 disease and 14.7% with >10 cm tumor size. Tumor cells expressed PD-L1 in 40% and TILs in 45.4% cases at a cut off of ≥1% was 17.3%, at ≥10% was 15.5% and at ≥50% was 7.3%. Significant association was seen between tumor proportion score (TPS) and increasing age, histological type, histological grade, tumor size, higher T stage (p = 0.03), TILs (p = 0.04), lymph vascular invasion, and perineural invasion. PDL-1 correlated with BRAF expression and microsatellite instability (MLH-1/PMS-2 expression loss). The overall survival was significantly higher (p < 0.001) with negative PDL1 expression in cases of colorectal carcinoma.

Conclusions:
Immunotherapy may be used as potential therapeutic option in colorectal carcinoma cases showing microsatellite instability and BRAF mutations which show poor response to conventional chemotherapy regimen and anti-EGFR therapy.
Prognostic effect of perineural invasion in successive years in patients with locally advanced gastric cancer
Authors: Uzun Orhan , Gülmez Selçuk , Senger Aziz Serkan , Ömeroğlu Sinan , Polat Erdal , Duman Mustafa 
Published: July 2021

Aim:
The present study evaluates the prognostic significance of perineural invasion (PNI) on 2-year, 5-year, and overall survival in patients undergoing gastrectomy and D2 lymphadenectomy due to locally advanced gastric cancer.

Materials and Methods:
Included in the study were 231 patients who underwent surgery between November 2006 and October 2018 due to stage 1B and over locally advanced gastric cancer, whose records were reviewed retrospectively.

Statistical Analysis:
The variables in the presence or absence of PNI were compared between the two groups with a Chi-square test, a Fisher's exact test, a likelihood ratio, and a Mann–Whitney U test. Overall survival data were evaluated with a Kaplan–Meier test. Prognostic factors were evaluated with a stepwise Cox regression analysis.

Results:
PNI was identified in 167 (72.3%) of the patients. The 2-year, 5-year, and overall survival rates at the end of the follow-up period were 85.9%, 70.3%, and 64.1% in those without PNI, and 52.7%, 38.3%, and 36.5% in those with PNI, respectively. In a multivariate analysis, PNI appeared to be a significant prognostic factor for 2-year survival (P = 0.04) but had no effect on 5-year and overall survival.

Conclusions:
Survival was shorter in patients with PNI than in patients without PNI, and PNI had no effect on overall survival, although it was found to be of prognostic significance for 2-year survival.
Medication take-back programs in Qatar
Authors: Hendaus Mohamed A. , Darwish Shereen , Saleh Manar , Mostafa Omar , Eltayeb Ahmed , Al-Amri Mohammed , Siddiqui Faisal J. , Alhammadi Ahmed 
Published: July 2021

Purpose:
To identify parental perception of a take-back program for medications.

Materials and Methods:
A cross-sectional study using a questionnaire was conducted at Hamad Medical Corporation, the only tertiary pediatric hospital in the State of Qatar at the time of the study. Qatar is a rapidly developing country with limited national data on the awareness of medication misuse among adults living with children at home and on the safety practices regarding medication disposal.

Results:
305 questionnaires were completed (response rate = 90%). More than 80% of parents were in between 20 and 39 years of age, 70% of them were females, and 80% were college graduates. Approximately 90% of participants have immediate relatives who were taking medications for chronic diseases. Almost 60% of parents stated that they keep unused medications at home, whereas 10% were not aware of the fate of the left over medications. Approximately 95% of the parents dispose the expired medications. In terms of the mode of disposing the medications, 66% of caregivers dispose the medication bottle or package in the trash can, whereas 14% remove the medications from the bottles or packages and throw them in the trash, and 15% put them through the drain. When asked if participants read disposal measures in the medication pamphlet, only 10% answered “always,” whereas 26% answered “sometimes.” Participants were asked if they have heard of any medications take-back programs, 75% answered no, whereas 14% were not sure. However, almost 60% of them will use the take-back program if available and 18% were not sure.

Conclusion:
Parents residing in the State of Qatar have deficiencies in knowledge about medication disposal. Parent's attitudes and perceptions are considered indispensable targets for community health intervention. Our next step is to share our data with the ministry of health to spread awareness about the proper disposal of medicines and take-back programs in Qatar.
Antiretroviral therapy outcomes among adolescents and young adults in a Tertiary Hospital in Kenya
Authors: Mburugu Patrick , Muiruri Peter , Opiyo Nelly , Simba Justus , Adunda Jane , Kawira Rosemary , Gachuno Onesmus 
Published: July 2021

Background: Limited data is available on the treatment outcomes of HIV infected adolescents and young adults (AYA) in sub-Saharan Africa. HIV-infected adolescents and young adults (AYA) are at high risk of developing antiretroviral treatment failure.
Objective: To determine the clinical, immunological and virologic outcomes of AYA at a tertiary hospital in Kenya.
Methodology: A longitudinal study was conducted among AYA age 10-24 years attending Kenyatta National Hospital comprehensive care center. Clinical data was abstracted from electronic medical records for study participants with at least 6 months of follow-up using a structured data abstraction sheet.
Results: A total of 250 AYA age 10 to 24 years were included. The median age was 16 years. The median CD4 cell count was 650.6 cells/mm3 (IQR 350.7-884.0). More than half (60.6%) of AYA had a CD4 cell count higher than 500 cells/mm3. Overall, 76.9% of AYA had achieved viral suppression (viral load <1000 copies/ml). There was a significant increase in virologic failure with higher age and late adolescents and young adults were more likely to have a viral load > 1000 copies/ ml p<0.012.
Conclusion: The overall virologic suppression in this cohort of AYA was sub-optimal. Both immunological and virologic outcomes were worse among late adolescents (18-19 years) and young adults (20-24 years).
Keywords: Adolescents; HIV; Kenya; virologic suppression; young adults.
A saúde coletiva: vivenciando a teoria na prática, como um relato de experiência
Authors: Rocha Francisca das Chagas Gaspar , De Souza Janice Maria Lopes , Penha Karla Janilee Souza , Lago Eliana Campêlo , Souto Laiane Araújo , Gomes Franco Celso da Silva , Varanda Maíra Damasceno Cunha 
Published: July 2021

RESUMO
Introdução: Este trabalho é um relato de experiência da disciplina saúde coletiva, do curso de graduação em Enfermagem, de uma faculdade privada de São Luís/MA, realizado nas Unidades de Estratégia Saúde da Família (UESFs). Objetivo: Dialogar sobre a experiência vivenciada pelos acadêmicos do 5º período e reforçar a importância da contextualização das aulas teóricas de saúde coletiva, contribuindo para a aprendizagem e sensibilização dos graduandos para a real situação da atenção básica. Metodologia: Relato de experiência, de visitas técnicas, dos alunos aos futuros campos de estágio, com escolha de cada grupo por um programa de saúde pública já implantado; ao final da visita cada grupo elaborou um relatório especificando: dados da estrutura de atendimento em saúde e da realidade social que o cerca, para tanto foi fornecido um roteiro de observações. Resultados: Foi possível identificar as potencialidades dos programas de saúde, suas lacunas, o perfil epidemiológico da população adscrita e contribuiu para a aproximação do alunado com a real situação de saúde no Brasil, desmistificando assuntos que pareciam estar longe da realidade dos acadêmicos.

ABSTRACT
Introduction: This work is an experience report of the collective health discipline, of the undergraduate Nursing course, of a private college in São Luís/MA, carried out in the Family Health Strategy Units (UESFs). Objective: Dialogue on the experience lived by students in the 5th period and reinforce the importance of contextualizing the theoretical classes of collective health, contributing to the learning and awareness of undergraduates about the real situation of primary care. Methodology: Experience report, technical visits, by students to future internship fields, with each group being chosen by an already implemented public health program; at the end of the visit, each group prepared a report specifying: data from the health care structure and the social reality that surrounds them, for which a script of observations was provided. Results: It was possible to identify the potential of health programs, their gaps, the epidemiological profile of the enrolled population and contributed to bringing students closer to the real health situation in Brazil, demystifying issues that seemed to be far from the reality of academics.
Pembahasan Soal Tes Potensi Skolastik pada SBMPTN 2020 untuk Meningkatkan Kualitas Pelayanan Online di Tengah Pandemi Covid 19 di Bimbel dan Privat MATRIKS
Authors: Nursyirwan Vivi Iswanti , Valentika Nina , Basir Choirul , Sastro Gerry , Ilmadi Ilmadi 
Published: July 2021

The purpose of community service carried out by the Pamulang University lecturer Team is to provide discussion assistance in answering questions about scholastic potential test to class XII high school students in preparing themselves to take part in the joint selection of state universities (SBMPTN) 2020. Partners in this community service are tutoring and private matrices in Pamulang, South Tangerang, Banten. The subject of community service is students in the public high school class XII who wish to enter state higher education through the SBMPTN 2020 test. The main problem faced by partners is that up to now Bimbel learning media has always been face to face and have never done online learning media, this because technologically Bimbel and private matrix not yet support in providing these services. The solution offered is to do online learning by online meeting application. The direct benefit of this dedication activity is an additional knowledge, skills in solving potential scholastic questions so that students can prepare for the joint selection of 2020 state universities with the method of solving problems quickly and easily. The derivate benefits are expected to be able to make students pass the SBMPTN 2020. This community service activity is carried out in the form of training by providing material and practice of completing the 2020 SBMPTN exam questions. The training is held for two weeks, namely in Monday to Friday, 11 -15 May 2020, and 18-22 May 2020. The method of activities used are practices, questions and answers and discussions. The analysis technique is done by observing aspects of student’s cognition and skills in conquering the subject matter.
Occupational Therapy for the Long Haul of Post-COVID Syndrome: A Case Report
Authors: Wilcox Jamie , Frank Emily 
Published: July 2021

Abstract
Prolonged symptoms from the novel coronavirus disease 2019 (COVID-19), otherwise known as long COVID, postacute sequelae of COVID-19 (PASC), or post-COVID syndrome, are affecting an increasingly high number of patients after severe, moderate, and mild acute COVID-19 infections. Using evidence-based practice strategies, this case report describes occupational therapy evaluation and treatment approaches, plan of care, and associated outcomes for one client experiencing long COVID symptoms in the outpatient setting.
Penerapan Machine Learning menggunakan algoritma C4.5 berbasis PSO dalam Menganalisa Data Siswa Putus Sekolah
Authors: Surip Agus , Pratama Muhamad Aji , Ali Irfan , Dikananda Arif Rinaldi , Purnamasari Ade Irma 
Published: July 2021

Pendidikan sangat memegang peranan penting dalam meningkatkan kualitas Sumber daya manusia yang ada di Indonesia. Untuk itu Pemerintah menggalakkan program wajib belajar 12 tahun. SMK As Salam, adalah salah satu Sekolah Menengah Kejuruan (SMK) swasta yang ada di Kecamatan Gegesik yang memiliki angka putus sekolah yang berubah setiap tahunnya. Ada beberapa penyebab seorang anak putus sekolah, diantaranya faktor ekonomi dimana orang tua tidak sanggup membiayai anaknya untuk sekolah, bisa juga faktor membantu usaha orang tua, faktor siswanya sendiri, atau faktor lingkungan dan teman – teman siswa tersebut. Perlu dilakukan penganalisaan terhadap data siswa agar dapat diklasifikasikan siswa yang berpotensi putus sekolah. Sehingga kepala sekolah dan bagian kesiswaan di SMK As Salam dapat mengambil keputusan agar siswa yang putus sekolah bisa diantisipasi setiap tahunnya. fokus maka penelitian ini adalah penggunaan model decision tree dalam mengkasifikasikan data putus sekolah yang dioptimasi menggunakan PSO di SMK As Salam Gegesik. Dari hasil klasifikasi tersebut diketahui nilai akurasi dari model decision tree tersebut adalah 90.86 %. Artinya keakuratan dalam klasifikasi tersebut sudah cukup baik. Sedangkan hasil klasifikasi model decision tree yang menggunakan PSO diketahui memiliki nilai akurasi 92.95 %. Artinya keakuratan dalam klasifikasi tersebut menjadi lebih baik dari decision tree yang tanpa optimasi PSO
Complications in the treatment of periprosthetic joint infection of the hip: when do they occur?
Authors: Li Katherine , Cuadra Mario , Scarola Gregory , Odum Susan , Otero Jesse , Griffin William , Springer Bryan D. 
Published: July 2021

Abstract. Prosthetic joint infection (PJI) is a devastating complication after total
hip arthroplasty (THA). The common treatment in the USA is a two-stage
exchange which can be associated with significant morbidity and mortality.
The purpose of this study was to analyze complications in the treatment
course of patients undergoing two-stage exchange for PJI THA and determine
when they occur.
Methods:
We analyzed all patients that underwent two-stage exchange arthroplasty for
treatment of PJI after THA from January 2005 to January 2018 at a single
institution. Complications were categorized as medical or surgical and divided
into interstage and post-reimplantation. Minimum follow-up was 1 year.
Success was based on the MusculoSkeletal Infection Society (MSIS)
definition.
Results:
205 hips (203 patients) underwent first stage of planned two-stage exchange.
The median age was 68 (interquartile range (IQR) 18). There were 97 males and 106 females.
Overall, 73/205 (38 %) patients had at least one complication during
treatment: 13.5 % (25/185) of patients experienced a medical complication
and 28.1 % (52/185) a surgical complication; 2.4 % died within 1 year
of surgery, and 4.9 % (15/203) had mortality at a median of 2.5 years (IQR 4.9); 27 % of patients had complications during the interstage period, most commonly being recurrence of infection requiring additional surgery
(63 %); and 14 % of patients experienced a complication following
reimplantation, most commonly persistence or recurrence of infection
(59 %). While 92 % of patients that initiated treatment were ultimately
reimplanted, only 69 % were infection free at 1 year and required no
additional treatment.
Conclusions:
While two-stage exchanges for PJI in THA have been reported as successful,
there are few reports of the complications during the process. In our
series, significant numbers of patients experienced complications, often
during the interstage period, highlighting the morbidity of this method of
treatment.
Writing domestic violence in Marian Keyes’ This Charming Man (2008)
Authors: O'Mahony Lauren , Trees Kathryn 
Published: July 2021

Popular fiction for women has been variously criticised and derided for a focus on romance plots and superficial themes. Marian Keyes, a prolific author of contemporary women’s popular fiction, however, utilises romance to explore serious contemporary issues. This paper examines the representation of one of these serious issues, domestic violence, in Keyes’ novel This Charming Man (2008). The novel’s multi-story plot gradually weaves together the histories and experiences of four female protagonists from their individual points of view. Each protagonist has had a romantic involvement with one ‘charming man’, the rich and powerful Irish politician Paddy de Courcy. Chapters devoted to each woman are interspersed with short vignettes that recount moments of Paddy’s violent behaviour. The narrative organisation of _This Charming Man_ represents domestic violence in a way that prioritises healing, physically, mentally and emotionally, for the protagonists through telling their stories and sharing those stories with other characters and readers. This form of creative writing prompts reader engagement and reflection. Such readerly engagement may increase awareness of this issue and potentially lead readers to actively seek change in their own lives.
Power in the moment: using autoethnographic narrative to unlock understandings of collaborative performance
Authors: Brown Judith 
Published: July 2021

Autoethnography provides a useful and valid way to research collaborative music performance as it enables the researcher to study their personal practice in relation to other musicians. However, the representation of data from collaborative performance creates some problems. It is here that narrative plays a vital role in being able to capture the essence of the moment from the perspective of the performer, through the use of evocative text. In examining the musical collaboration between a pianist and a choir, the analysis of the narrative data provides a rich understanding of the unseen aspects of collaborative practice in music performance, while also providing an exemplar for other creative artists who are researching the experience of artistic practice. This case study demonstrates that evocative autoethnographic narrative is a significant tool for this type of research activity, and can have wide application in the creative arts.
Sosialisasi dan Pendampingan Dampak Peran Ganda Buruh Perempuan terhadap Kehidupan Rumah Tangga di Desa Bunder Kecamatan Jatiluhur Kabupaten Purwakarta
Authors: Gussevi Sofia , Tadjudin Azi Ahmad , Amaliah Fika Tantri 
Published: July 2021

Kegiatan pengabdian ini dilatarbelakangi dari hasil observasi penulis mengenai banyaknya ibu rumah tangga yang menjadi buruh pabrik untuk memenuhi ekonomi keluarga di desa Bunder, Kecamatan Jatiluhur, Kabupaten Purwakarta. Tentunya peran ganda buruh perempuan ini akan berdampak terhadap kehidupan rumah tangga mereka. Berdasarkan hal tersebut, kegiatan ini bertujuan untuk memberikan sosialisasi tentang dampak peran ganda perempuan terhadap kehidupan rumah tangga dan upaya keluarga buruh perempuan untuk mengatasi dampak peran ganda tersebut dengan melakukan pendampingan terhadap beberapa keluarga di desa Bunder Kecamatan Jatiluhur Kabupaten Purwakarta. Hasil dari kegiatan ini diperoleh bahwa peran ganda buruh perempuan dapat menimbulkan dampak positif dan negatif terhadap kehidupan rumah tangga, di antaranya yaitu : (1) Dampak positif : menambah penghasilan dan terbangun rasa saling pengertian antar anggota keluarga; (2) Dampak negatif : waktu untuk berkumpul dengan keluarga terbatas dan adanya beban kerja ganda yang ditanggung oleh buruh perempuan. Upaya yang dilakukan keluarga buruh perempuan dalam mengatasi dampak dari peran gandanya yaitu : (1) manajemen waktu yang baik dan (2) memberikan motivasi pada diri sendiri dan suami selalu menyemangati isteri.
Oportunidad de exportación de aguacate Hass a Francia
Authors: Garzón Ana 
Published: July 2021

Las cadenas productivas en los últimos años han incentivado la internacionalización de los productos del sector agrícola del país. Con un adecuado apoyo a los productores de aguacate Hass cultivado en el departamento del Tolima, a través de emprendimientos asociativos solidarios, se pretendió buscar la manera de eliminar canales de distribución
innecesarios, con el fin de que tuvieran la oportunidad de exportar directamente y así obtener una utilidad más justa. Por esa razón, desde la academia se procuró proveer a los cultivadores de toda la información, así como las herramientas requeridas para llevar sus productos a los mercados externos de manera directa, eliminando intermediarios que disminuyen la competitividad en el exterior. Así, a través de recolección y análisis de información sobre requisitos de admisibilidad, aprovechamiento de acuerdos al mercado de Francia; además, la preparación con base en la experiencia de algunas herramientas de apoyo como oferta económica, gastos logísticos y la formulación de un plan exportador para su desarrollo que les permita llegar a los mercados externos de manera directa con mayores beneficios y una ventaja competitiva más eficiente.