bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low back pain – a review
Authors: Rusiński Kacper , Klimas Filip , Zatłoka-Mazur Dorota , Sienkiewicz Michał , Pawłowski Bartosz , Potoczek Adriana , Zięba Zuzanna , Pudełko Iwona , Gajda Zuzanna 
Published: February 2025

Low back pain (LBP) is a common condition affecting many individuals worldwide. Furthermore, it represents a significant economic challenge for healthcare systems due to its substantial associated costs. The etiology of LBP is complex but, in most cases, is not caused by serious underlying diseases. Physical examination remains the cornerstone of diagnosis, while additional tests, including imaging, are determined based on the clinical context. Treatment involves a combination of non-pharmacological, pharmacological, and invasive interventions. Despite numerous attempts to prevent LBP, only a few methods have been scientifically proven to be effective.
The aim of this review was to provide a comprehensive summary of evidence-based information and approaches regarding the pathogenesis, treatment, and prevention of LBP. The literature reviewed was sourced from PubMed and Google Scholar Rusing the key words "low back pain" combined with terms such as "pathogenesis," "diagnostics," "imaging diagnostics," "treatment," and "prevention."
Clinical guidelines for the care of children aged under 5 with asthma: An overview of the recent national guidelines
Authors: Henry Heather 
Published: February 2025

Heather Henry explains why it is critical that nurses in primary and community health services understand what has been described as a ‘sea change’ in the national guidelines for managing asthma This is the first of 3 articles providing an in-depth overview of the recently updated British Thoracic Society (BTS), Scottish Intercollegiate Guidelines Network (SIGN), and National Institute for Health and Care Excellence (NICE) guidelines for the care of people with asthma, published on 27 November 2024. This article aims to equip nurses with the knowledge and tools needed to deliver evidence-based care and improve outcomes for children with asthma aged under 5 years.
Leveraging natural language processing for efficient information extraction from breast cancer pathology reports: Single-institution study
Authors: Park Phillip , Choi Yeonho , Han Nayoung , Park Ye-Lin , Hwang Juyeon , Chae Heejung , Yoo Chong Woo , Choi Kui Son , Kim Hyun-Jin 
Published: February 2025

Background
Pathology reports provide important information for accurate diagnosis of cancer and optimal treatment decision making. In particular, breast cancer has known to be the most common cancer in women worldwide.

Objective
For the data extraction of breast cancer pathology reports in a single institute, we assessed the accuracy of methods between regular expression and natural language processing (NLP).

Methods
A total of 1,215 breast cancer pathology reports were annotated for NLP model development. As NLP models, we considered three BERT models with specific vocabularies including BERT-basic, BioBERT, and ClinicalBERT. K-fold cross-validation was used to verify the performance of the BERT model. The results between the regular expression and the BERT model were compared using the named entity recognition (NER) techniques.

Results
Among three BERT models, BioBERT was the most accurate parsing model (average performance =  0.99901) for breast cancer pathology when set to k = 5. BioBERT also had the lowest error rate for all items in the breast cancer pathology report compared to other BERT models (accuracy for all variables ≥ 0.9). Therefore, we finally selected BioBERT as the NLP model. When comparing the results of BioBERT and regular expressions using NER, we identified that BioBERT was more accurate than regular expression method, especially for some items such as intraductal component (BioBERT: 1.0, RegEx: 0.1644), lymph node (BioBERT: 0.9886, RegEx: 0.4792), and lymphovascular invasion (BioBERT: 0.9918, RegEx: 0.3759).

Conclusions
Our results showed that the NLP model, BioBERT, had higher accuracy than regular expression, suggesting the importance of BioBERT in the processing of breast cancer pathology reports.
Entire radial bounded solutions for Leray-Lions equations of (p, q)-type
Authors: Mennuni Federica , Mugnai Dimitri , Salvatore Addolorata 
Published: February 2025

Abstract
We prove the existence of entire, radial, and signed bounded solutions for a quasilinear elliptic equation in

R

N

{{\mathbb{R}}}^{N}

driven by a Leray-Lions operator of the (p, q)-type. For this, we need an extension of related results by Boccardo-Murat-Puel and a variational approach in intersections of Banach spaces introduced by Candela-Palmieri.
Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
Authors: Wang Qing , Zhang Ting , Feng Xinting , Chen Peng , Feng Ye , Huang Haoqiang , Qian Yinhua , Guo Yang , Yin Zifei 
Published: February 2025

Abstract

Background
Osteoporosis (OP) is a systemic bone disorder marked by reduced bone mass and disrupted microstructure, leading to higher fracture risk. Epidemiological data from China show a 20.7% prevalence in women and 14.4% in men over 50, underscoring a pressing health issue given the aging population. More drugs to inhibit OP progression should be explored, and their biological mechanisms confirmed in preclinical studies.

Methods
In this study, we utilized Lycium barbarum polysaccharide (LBP), an extract from the traditional Chinese medicine Goji Berry. LBP, known for its range of pharmacological activities, was assessed for its potential therapeutic effects on OP. We specifically investigated its influence on the proliferation, apoptosis, migration, and functional differentiation of osteoblasts and osteoclasts.

Results
LBP significantly promotes osteoblast proliferation, migration, and osteogenic differentiation. Conversely, it inhibits the intrinsic apoptotic response in osteoblasts. For osteoclasts, LBP suppressed their proliferation, migration, and osteoclastic differentiation while enhancing their natural apoptosis. These results were confirmed by classical protein pathway detection experiments.

Conclusion
LBP showcases potential therapeutic properties against OP, particularly in modulating osteoblast/osteoclast activities. While its exact mechanisms through vital signaling pathways remain to be fully elucidated, LBP’s prominent effects suggest that it is a promising agent for OP intervention, warranting further in-depth studies.
Evaluation of color matching of three single-shade composites employing simulated 3D printed cavities with different thicknesses using CIELAB and CIEDE2000 color difference formulae
Authors: Kariper Engin , Cilingir Aylin 
Published: February 2025

Abstract
This study assessed the color-matching capability of three single-shade composites that employ simulated resin 3D-printed cavities with different cavity depths using CIELAB and CIEDE2000 formulas. A cylindrical model with standardized cavities was generated. One hundred and fifty blank specimens were fabricated and divided into three groups (n = 50) and then into five subgroups. The five subgroups included four groups of specimens with 0.5, 1, 2, and 4 mm cavities and a control group of specimens without cavities (n = 10). Cavities were filled with Vittra Unique (VU), Omnichroma (OC), and OptiShade (OS). Color measurements were done using a clinical spectrophotometer. The color differences for all composites were calculated as ΔE and ΔE
00 using CIELAB coordinates. The color parameter data were analyzed (α = 0.05). OS had significantly lower ∆E and ∆E
00 values than the other composites for all layer thicknesses (p < 0.05). VU, OC, and OS had the lowest ∆E and ∆E
00 values at 0.5 mm (p < 0.05). Color matching of monochromatic composites decreased as the layer thickness increased. OS achieved the best color matching in this study. Single-shade composites are important for reducing chairside time and gaining confidence in clinical practice. CIELAB and CIEDE2000 color difference formulae can be used in different studies with similar results.
Impact of non-alcoholic fatty liver disease on cognition and brain changes: a comprehensive review
Authors: He Huijing , Gao Hongjian , Zhang Yubo , Wang Qi , Li Zongyang , Wu Shuicai , Wen Caiyun 
Published: February 2025

Abstract
This review explores the correlation of non-alcoholic fatty liver disease (NAFLD) with cognitive function and brain changes. A comprehensive search of relevant studies in the PubMed database up to June 2024 was conducted, including various study designs such as cross-sectional, longitudinal, case-control, and cohort studies. Data were extracted from 24 studies, focusing on study design, sample size, NAFLD diagnosis, control of confounders, key findings, and limitations. Neuropsychological tests utilized within each study were grouped into relevant cognitive domains. Statistical analyses and comparisons were also performed on the observed changes in brain parameters across the studies. The meta-analysis on the domain of general cognition was conducted. Results indicated that NAFLD was significantly associated with general cognition, executive function, attention, and memory. NAFLD impacts the total brain volume, the volumes of specific brain regions and certain high-intensity brain regions, the cerebral blood flow and perfusion, the integrity of nerve fiber bundles, and the brain abnormalities or lesions such as cerebral hemorrhage, cerebral microbleeds, and white matter lesions. NAFLD also affects the thickness and surface area of certain cortical regions and the resting-state brain function MRI indicators in specific brain areas. Despite these findings, the included studies varied in design, population characteristics, and outcome measures, which introduced heterogeneity that might influence the generalizability of the results. Overall, NAFLD is associated with a decline in cognitive function and alterations in certain brain parameters. Furthermore, NAFLD may exert its influence on cognition by impacting brain structure.
Analysis of External Load Variables Defining Competitive Demands in Elite Futsal Through Monitoring With Tracking Systems: A Systematic Review
Authors: Albalad-Aiguabella Rafael , Mainer-Pardos Elena , Casajús José Antonio , Vicente-Rodríguez Germán , Muniz-Pardos Borja 
Published: February 2025

ABSTRACT
The popularity of futsal is growing worldwide, leading to a greater professionalization of the sport and requiring coaches to have a deeper knowledge of its competitive demands. Advanced tracking systems allow for monitoring the physical demands associated with external load, which may aid coaches in understanding critical aspects to maximize sports performance. The present systematic review aims to identify the competitive demands of futsal in terms of external load measured via tracking systems. A search was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines in Web of Science, Scopus (Elsevier), and PubMed databases up to November 2023. Of the 318 citations, 12 met the inclusion criteria. High-intensity actions are important for futsal performance. The main external loading variables that assess efforts in elite futsal are total distance, distance covered per minute, high-intensity running, accelerations, and decelerations. It is essential to analyze the external load variables relative to time. In addition, and for a deeper understanding, the analysis of the physical demands should be further explored according to specific player positions (defenders, wingers, or pivots). Futsal performance seems to be determined by the player's ability to repeat multiple high-intensity actions in very short periods.
Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner
Authors: Omana Suarez Genesis , Kumar Divya S. , Brunner Hannah , Knauss Anneke , Barrios Jenifer , Emel Jalen , Teel Jensen , Botero Valentina , Broyles Connor N. , Stahl Aaron , Bidaye Salil S. , Tomchik Seth M. 
Published: February 2025

Genetic disorders such as neurofibromatosis type 1 increase vulnerability to cognitive and behavioral disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder. Neurofibromatosis type 1 results from mutations in the neurofibromin gene that can reduce levels of the neurofibromin protein (Nf1). While the mechanisms have yet to be fully elucidated, loss of Nf1 may alter neuronal circuit activity leading to changes in behavior and susceptibility to cognitive and behavioral comorbidities. Here we show that mutations decreasing Nf1 expression alter motor behaviors, impacting the patterning, prioritization, and behavioral state dependence in aDrosophilamodel of neurofibromatosis type 1. Loss of Nf1 increased spontaneous grooming in male and female flies. This followed a nonlinear spatial pattern, with Nf1 deficiency increasing grooming of certain body parts differentially, including the abdomen, head, and wings. The increase in grooming could be overridden by hunger in foraging animals, demonstrating that the Nf1 effect is plastic and internal state dependent. Stimulus-evoked grooming patterns were altered as well, suggesting that hierarchical recruitment of grooming command circuits was altered. Yet loss of Nf1 in sensory neurons and/or grooming command neurons did not alter grooming frequency, suggesting that Nf1 affects grooming via higher-order circuit alterations. Changes in grooming coincided with alterations in walking. Flies lacking Nf1 walked with increased forward velocity on a spherical treadmill, yet there was no detectable change in leg kinematics or gait. These results demonstrate that loss of Nf1 alters the patterning and prioritization of repetitive behaviors, in a state-dependent manner, without affecting low-level motor functions.Significance statementNeurofibromatosis type 1 (NF1) is associated with an increased risk of cognitive and behavioral disorders, yet the underlying neuronal mechanisms remain poorly understood. Our study utilizes aDrosophilamodel to demonstrate that loss of neurofibromin (Nf1) expression impacts motor behavior and the prioritization of repetitive actions, such as grooming, in a hunger state-dependent manner. Our experiments also suggest that alterations in neuronal circuit activity due to the loss of Nf1 influence behavior without impairing motor coordination. Understanding how Nf1 loss affects motor function can reveal the broader neuronal mechanisms contributing to cognitive impairment, providing valuable insights for developing therapeutic strategies.
Sleep modulates neural timescales and spatiotemporal integration in the human cortex
Authors: Cusinato Riccardo , Seiler Andrea , Schindler Kaspar , Tzovara Athina 
Published: February 2025

Spontaneous neural dynamics manifest across multiple temporal and spatial scales, which are thought to be intrinsic to brain areas and exhibit hierarchical organization across the cortex. In wake, a hierarchy of timescales is thought to naturally emerge from microstructural properties, gene expression, and recurrent connections. A fundamental question is timescales’ organization and changes in sleep, where physiological needs are different. Here, we describe two measures of neural timescales, obtained from broadband activity and gamma power, which display complementary properties. We leveraged intracranial electroencephalography (iEEG) in 106 human epilepsy patients (48 females) to characterize timescale changes from wake to sleep across the cortical hierarchy. We show that both broadband and gamma timescales are globally longer in sleep than in wake. While broadband timescales increase along the sensorimotor-association axis, gamma ones decrease. During sleep, slow waves can explain the increase of broadband and gamma timescales, but only broadband ones show a positive association with slow-wave density across the cortex. Finally, we characterize spatial correlations and their relationship with timescales as a proxy for spatiotemporal integration, finding high integration at long distances in wake for broadband and at short distances in sleep for gamma timescales. Our results suggest that mesoscopic neural populations possess different timescales that are shaped by anatomy and are modulated by the sleep/wake cycle.Significance statementUnderstanding the organization of intrinsic neural dynamics is crucial for investigating brain functions in health and disease. A key question is: how do neural dynamics change in the sleeping brain? Here we focus on neural timescales and spatial correlations. We show that two broadband and gamma timescales manifest within neural populations recorded with intracranial electroencephalography in humans. Both timescales increase in sleep but follow opposite hierarchies: broadband timescales increase from sensory to associative areas, while gamma show the reverse pattern. Finally, timescales covary with spatial correlations, suggesting higher spatiotemporal integration over long distances in wake compared to sleep.
Rescue Strategy in Cardiogenic Shock: Emergency Transcatheter Aortic Valve Implantation for Failed Bioprosthetic Valve – Case Report
Authors: Kundelis Ricardas , Bajoras Vilhelmas , Čėsna Sigitas , Davidavičius Giedrius 
Published: February 2025

Background: Transcatheter aortic valve implantation (TAVI) has emerged as an essential therapeutic intervention for patients with severe aortic valve disease, providing a less invasive alternative to traditional surgery, particularly in high-risk individuals. TAVI is also increasingly utilized as a valve-in-valve strategy in cases of a bioprosthetic valve failure. However, data on the efficacy of TAVI in the context of a hemodynamic collapse remain limited.Methods: This report represents a young, high-risk patient with a failed bioprosthetic valve and cardiogenic shock treated successfully with TAVI.Results: Emergency TAVI using a Medtronic Evolut Pro+ device achieved rapid hemodynamic stabilization and favorable post-procedural clinical and functional outcomes. Intermittent complete atrioventricular block necessitated the implantation of a permanent pacemaker.Conclusions: This case highlights the potential of TAVI as a safe and effective intervention in critical clinical scenarios. Emergency TAVI is a viable therapeutic intervention for patients with failed surgical bioprostheses presenting with cardiogenic shock.
TISSUE ENGINEERED MATRIX BASED ON SILK FIBROIN FOR CARDIOVASCULAR SURGERY
Authors: Senokosova Evgenia A. , Matveeva Vera G. , Khanova Maryam Yu. , Krivkina Evgenia O. , Mironov Andrey V. , Onischchenko Pavel S. , Mukhamadiyarov Rinat A. , Antonova Larisa V. 
Published: February 2025

HighlightsThe article reports on the progress in the development of a method for producing porous nonwoven material based on silk fibroin, and the following study of its structural, physical, and mechanical properties. The findings indicate that the obtained material is similar in its characteristics to the native artery thus proving that silk fibroin has a high potential in vascular tissue engineering. AbstractBackground. Natural polymer – silk fibroin, obtained from silkworm cocoons, is a promising biomaterial. Tissue engineering has allowed us to obtain 3D-scaffolds based on silk fibroin for cardiovascular surgery.Aim. To make a porous matrix based on regenerated silk fibroin (SF) and to study its characteristics in vitro.Methods. Silk was refined in an alkaline solution with further dissolution in LiBr, dialysis and freeze drying to obtain sponges. Matrices based on 15%, 18% and 20% SF in hexafluoroisopropanol were manufactured by electrospinning. By incubation in ethanol, methanol or isopropanol the β-sheet of SF was made water-insoluble. The structure of the matrix surface and the cross-section were studied by scanning electron microscopy. Physical and mechanical characteristics were evaluated using a universal bursting strength tester.Results. The optimal electrospinning parameters for 15% solution were as follows: needle 22 G; tip to collector 15 cm; voltage 20 kV; solution feed rate 1.0 mL/h; rotational speed of 200 rpm; humidity 65% and room temperature 23 °C. The obtained matrix had “flat fibers” with a width of 4.84 (4.20; 5.47) microns and a small number of shallow pores with a diameter of 8.65 (5.01; 11.13) microns. The walls of the matrix consisted of fibers with a diameter of 11.70 (10.04; 13.90) microns with a large number of pores with a diameter of 4.89 (4.46; 6.05) microns. Incubation of samples in 70% ethanol allowed us to form a non-water-soluble form of the SF matrix that has physical and mechanical characteristics comparable to sheep carotid arteries.Conclusion. We have developed a porous 3D matrix based on 15% silk fibroin with satisfactory structural, physical and mechanical characteristics. It is necessary to further conduct in vitro studies to fully understand the characteristics of the manufactured material for further testing on in vivo models.
ASSOCIATION OF BETA-ADRENOREACTIVITY OF ERYTHROCYTE MEMBRANES WITH THE SEVERITY OF CHRONIC HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE
Authors: Muslimova Elvira F. , Rebrova Tatiana Yu. , Sonduev Erdeni L. , Popova Valeriya O. , Kozlov Boris N. , Afanasiev Sergey A. 
Published: February 2025

HighlightsBeta-adrenoreactivity of erythrocyte membranes (beta-ARM) is an indirect indicator of the activity of the sympathoadrenal system and can act as a marker of the severity of heart failure. In patients with chronic coronary artery disease, higher beta-ARM values are associated with a lower left ventricular ejection fraction. Beta-ARM is elevated in people who have suffered a prior myocardial infarction. AbstractAim. To assess the relationship between erythrocyte membrane beta-adrenoreactivity (beta-ARM) and the level of catecholamines in the blood with the functional state of the myocardium in patients with chronic heart failure (CHF) of ischemic origin.Methods. The study included 116 patients with chronic ischemic heart disease, of which 56.9% of patients had postinfarction cardiosclerosis (PICS). In the sample, functional class (FC) I CHF was present in 10.3% of patients, FC II in 56.0% of patients, and FC III in 33.6% of patients. Based on echocardiography data, CHF with preserved left ventricular ejection fraction (LVEF≥50%) was detected in 78.4% of patients, in 7.8% of patients with reduced LVEF<40%, and in 13.8% of patients with mid‐range LVEF 40–49%. The levels of adrenaline and norepinephrine in the blood plasma were determined using the ELISA kits. Beta-ARM was assessed using the Beta-ARM-Agate kit in accordance with the manufacturer's protocol.Results. The study sample revealed an inverse relationship between beta-ARM and LVEF (r = –0.318, p = 0.001), as well as a direct correlation with the LV sphericity index (r = 0.331, p = 0.001). An inverse linear relationship was found between the LVEF and the level of adrenaline (r = –0.287, p = 0.010) and norepinephrine (r = –0.418, p < 0.001). Patients with PICS had higher values of beta-ARM (29.7% (19.2; 39.1) vs 21.4% (14.8; 26.7), p = 0.004) and norepinephrine (30.5% (24.3; 41.8) vs 26.9% (19.6; 30.1), p = 0.042) compared with patients without PICS. Groups with different CHF FCs had comparable levels of catecholamines, but differed in beta-ARM (p = 0.029): 22.8% (19.5; 29.2) with FC I, 21.4% (14.8; 28.4) with FC II, 30.1% (19.4; 40.1) with FC III. There was a tendency towards differences in beta-ARM between groups in LVEF (p = 0.053).Conclusion. Thus, the results of the study revealed an association between beta-ARM and norepinephrine levels with systolic myocardial dysfunction. Higher values of beta-ARM and norepinephrine correlate with lower LVEF and indicate an unfavorable course of heart failure.