bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH MEDIA PEMBELAJARAN BIGBOOK TERHADAP KEMAMPUAN MENYIMAK ANAK TK AL-WATHANIYAH KECAMATAN KOTA TIMUR KOTA GORONTALO
Authors: Kuku Alfasana , Arsyad Lukman 
Published: September 2021

Tujuan Penelitian ini yaitu ingin mengetahui apakah ada pengaruh media pembelajaran bigbook terhadap kemampuan menyimak anak. Penelitian ini menggunakan jenis penelitian eksperimen dengan menggunakan pendekatan kuantitatif untuk mendapatkan informasi yang lengkap dan mendalam mengenai pengaruh media pembelajaran bigbook terhadap kemampuan menyimak anak pada kelompok A TK Al- wathaniyah kecamatan kota timur kota gorontalo. Populasi dalam penelitian ini berjumlah 18 sehingga penelitian ini dikatakan sebagai penelitian populasi. Selanjutnya pengumpulan data penulis menggunakan observasi, angket, tes dan dokumentasi, dan jenis analisis data menggunakan tahapan SPSS 16. Berdasarkan hasil penelitian uji t menunjukkan bahwa media pembelajaran bigbook memiliki pengaruh yang signifikan terhadap kemampuan menyimak anak yaitu sebesar 95% dan di peroleh thitung = -23.252 dan nilai sig.(2-tailed) = 0.000. Sebab Nilai signifikannya 0.000 < 0.005 maka H0 di tolak dan Hi diterima. Dengan demikian media pembelajaran bigbook berpengaruh positif terhadap kemampuan menyimak anak. Dari penelitian ini guru dapat mengetahui seberapa besar pengaruh pemberian media pembelajaran bigbook terhadap kemampuan menyimak anak. Sehingga diharapkan kepada guru lebih kreatif memilih media yang digunakan sehingga peserta didik lebih bersemangat untuk menerima pelajaran.
Pengembangan Teori Pembelajaran Humanisme menurut Jurgen Habermas serta Relevansinya Dalam Pendidikan Islam
Authors: Labaso' Syahrial , Hestiana Ratna 
Published: September 2021

Teori pembelajaran humanisme meyakini bahwa proses pendidikan tidak diarahkan untuk membentuk kompetensi peserta didik, tetapi sebaliknya dimaksudkan untuk mengembangkan potensi yang melekat dalam diri peserta didik itu sendiri, sebagai pribadi yang unggul dan istimewa. Sehingga sudut pandang yang digunakan ialah sudut pandang dari peserta didik sebagai individu pembelajar, sementara peran pendidik (guru) sebatas pada upaya dan usaha untuk memfasilitasi kebutuhan perkembangan diri dari peserta didik tersebut. Dalam proses pengembangannya menurut Jurgen Habermas, teori pembelajaran humanisme dapat dilaksanakan melalui tiga tahapan belajar, yaitu: belajar teknis (technical learning), belajar praktis (practical learning), dan belajar emansipatoris (emancipator learning). Melalui tiga tahapan belajar tersebut, peserta didik diharapkan dapat mencapai kesadaran yang utuh mengenai dirinya dan lingkungan sosialnya, hal inilah yang sekaligus menjadikan teori pembelajaran humanisme yang dikembangkan oleh Jurgen Habermas selaras dengan tujuan pendidikan Islam, sebab pada akhinya output dari teori pembelajaran humanisme ialah mencapai kearifan dan bijaksanaan hidup, sehingga seorang peserta didik dapat mengenali siapa dirinya, berikut peran sosial yang harus dilakukannya ditengah-tengah lingkungannya, sehingga pada akhirnya peserta didik dapat mengembangkan potensi dirinya dengan semaksimal mungkin, tanpa tercerabut dari lingkungan kulturalnya.
Norovirus Structure and Classification
Authors: Rani Manisha , Rajyalakshmi Sushma , Pakalapaty Sunitha , Kammilli Nagamani 
Published: September 2021

Norovirus are a major cause of acute gastroenteritis worldwide. Diarrheal disease is now the fourth common cause of mortality children under the age of 5 years but remain the 2nd most cause of morbidity. NoV are associated with 18% diarrheal diseases worldwide where rotavirus vaccinations has been successfully introduced. NoV has become major cause of gastroenteritis in children. NoV belong to family caliciviridae. They are non-enveloped, single stranded positive sense RNA Viruses. The genome consists of 3 Open reading frames, ORF-1 codes for non-structural protein, ORF-2 codes for major capsid protein VP1 and ORF-3 for minor capsid protein VP2. Based on sequence difference of the capsid gene (VP1), NoV have been classified in to seven genogroup GI-GVII with over 30 genotypes. Genogroups I, II, IV are associated with human infection. Despite this extensive diversity a single genotype GII.4 has been alone to be the more prevalent. Basic epidemiological disease burden data are generated from developing countries. NoV are considered fast evolving viruses and present an extensive diversity that is driven by acquisition of point mutations and recombinations. Immunity is strain or genotype specific with little or no protection conferred across genogroups. Majority of outbreaks and sporadic norovirus cases worldwide are associated with a single genotype, GII.4 which was responsible for 62% of reported NoV outbreaks in 5 continents from 2001 to 2007. GII.4 variants have been reported as major cause of global gastroenteritis pandemics starting in 1995 frequent emergence of novel GII.4 variants is known to be due to rapid evolution and antigenic variation in response to herd immunity. Novel GII.4 variants appear almost every 2 years. Recent GII.4 variant reported include Lordsdale 1996, Farmington Hills 2002, Hunter 2004, Yerseke 2006a, Den Haag 2006b, Apeldoon 2007, New Orleans 2009,most recently Sydney 2012. Detailed molecular epidemiologic investigation of NoV is associated for understanding the genetic diversity of NoV strain and emergence of novel NoV variants. However, reports have revealed that not all individuals develop symptoms and a significant proportion remains asymptomatic after NoV infections.
Hvad skjuler øjnene bag kameraet
Authors: Heide Mette 
Published: September 2021

I slutningen af James Bond-filmen For Your Eyes Only er agent 007 alene med en „pige“.
Hun lader sin badekabe falde ned fra skuldrene og siger til ham: „or your eyes only“.
Det er meget pracist, for publikum far ikke lov til at se, hvad Bond har blik for. Kameraet
viser nemlig ikke den til lejligheden udvalgtes hemmeligheder. Lignende
afslutningssekvenser er velkendte fra andre James Bondfilm. Han ser noget, som kameraet
skjuler for publikums blik. Tilskueren er hensat til at give fantasien frit lob.
De overordnede kategorier, man filmteoretisk kan inddele blikke i, er skuespillernes,
kameraets og publikums blik. Skuespillernes blikke er rettet mod andre aktorer eller
objekter, som kan vare inden for eller uden for billedfeltet. Billedfeltet er det, kameraets
oje har indfanget, og det er det oje, der leder publikums blik.
Publikums blik er af en rakke teoretikere blevet opfattet som et blik, der indeholder
mere end blot det at beskue en filmisk fortalling. Blikket er blevet karakteriseret som
voyeuristisk.1 Et blik, der beskuer noget, som er synligt. Noget, der i sin struktur lader sig
vare synligt, men som ikke afslorer, at det bliver beskuet. Publikum kan se uden at blive
intimideret i sin skuelyst.
Nu skal denne artikel ikke dreje sig om, hvordan publikum ser, og hvorfor det ser.
Det, der vil blive fokuseret pa, er det konkrete blik, der viser sig i fiktionsfilm. Det vil
sige skuespillernes og sekundart kameraets blik. I det folgende skal det dog indledningsvis
uddybes, hvorfor publikums kiggeri ikke afslores. Kilden til det trak skal
nemlig findes i konventionen for skuespillernes blikke. I forlangelse af dette vil det kort
blive belyst, hvordan blikke i faktaformidling afviger fra fiktionsfilmens blikkonventioner.
Herefter vil blikkets funktioner som synshandling og synsmade i fiktionsfilm
mere grundigt blive belyst i forhold til en film, nemlig Hitchcocks Skjulte øjne fra 1954.
Kannibalernes klaptræ - og andre smuler til en optisk encyclopædi
Authors: Knudsen Anne 
Published: September 2021

Vores kunst er dét, som øjnene tænker
- Cézanne

Videnskaben tanker med blikket. Blikket vandrer rundt i forskningens landskab og
udsoger sig forskningsobjekter, idet „vi med øjnene følger tingenes egne bevagelser og
konturer" (Merleau-Ponty 1969: 269, fremhav, orig.). Men hvis ojnene selv tanker,
sadan som Cezanne siger det, sa er de maske ikke vore tro tjenere? Maske tanker de om
hjorner med os? Blikket har spillet en overordentlig rolle i de seneste par arhundreders
videnskabelighed og ikke kun som metafor i skikkelse af overblik, indblik, klarhed og
evidens. Blikket er et af de allervasentligste redskaber i forskningen, et redskab som pa
en gang er personligt, palideligt og praktisk, fordi det sa at sige altid er ved handen. Vi
stotter os tillidsfuldt til blikket.
Det har ganske vist lange varet et anerkendt faktum, at der findes forskellige synsvinkler
(og at meget afhanger af dem), men den mulige eksistens af virkeligt forskellige
blikke har varet temmelig underbetonet uden for de bildende kunster og forskningsdiscipliner
som kunsthistorie og filmvidenskab.3 Men de meldinger, som kommer herfra,
har til gengald lange varet sa forstyrrende, at det ma give anledning til overvejelser. Det
lader nemlig til, at der ganske afgjort findes fundamentalt forskellige blikke. Det er indtil
videre ikke fastslaet, hvordan disse blikke forholder sig til hinanden. I det folgende vil
jeg derfor foresla en slags encyclopadisk tilgang til blikkenes variationer. Altsa et
ordningsprincip, som ikke uden videre hierarkiserer optikkeme.
Staf Callewaert: Kultur, pædagogik og videnskab. Habitusbegrebet og praktikteorien hos Pierre Bourdieu
Authors: Schade-Poulsen Marc 
Published: September 2021

Staf Callewaert: Kultur, pædagogik og videnskab. Habitusbegrebet og praktikteorien hos Pierre Bourdieu
Anmeldes af Marc Schade-Poulsen
Esther Fihl & Jens Pinholt (red.): Livsformer og kultur: Antropologi i praktisk anvendelse
Authors: Sjørslev Jens 
Published: September 2021

Esther Fihl & Jens Pinholt (red.): Livsformer og kultur: Antropologi i praktisk anvendelse
Anmeldes af Jens Sjørslev
Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease
Authors: Abudupataer Mieradilijiang , Zhu Shichao , Yan Shiqiang , Xu Kehua , Zhang Jingjing , Luo Shaman , Ma Wenrui , Alam Md Fazle , Tang Yuyi , Huang Hui , Chen Nan , Wang Li , Yan Guoquan , Li Jun , Lai Hao , Wang Chunsheng , Zhu Kai , Zhang Weijia 
Published: September 2021

Background:Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and is frequently associated with the development of thoracic aortic aneurysm (TAA). There is no effective strategy to intervene with TAA progression due to an incomplete understanding of the pathogenesis. Insufficiency of NOTCH1 expression is highly related to BAV-TAA, but the underlying mechanism remains to be clarified.Methods:A comparative proteomics analysis was used to explore the biological differences between non-diseased and BAV-TAA aortic tissues. A microfluidics-based aorta smooth muscle-on-a-chip model was constructed to evaluate the effect of NOTCH1 deficiency on contractile phenotype and mitochondrial dynamics of human aortic smooth muscle cells (HAoSMCs).Results:Protein analyses of human aortic tissues showed the insufficient expression of NOTCH1 and impaired mitochondrial dynamics in BAV-TAA. HAoSMCs with NOTCH1-knockdown exhibited reduced contractile phenotype and were accompanied by attenuated mitochondrial fusion. Furthermore, we identified that mitochondrial fusion activators (leflunomide and teriflunomide) or mitochondrial fission inhibitor (Mdivi-1) partially rescued the disorders of mitochondrial dynamics in HAoSMCs derived from BAV-TAA patients.Conclusions:The aorta smooth muscle-on-a-chip model simulates the human pathophysiological parameters of aorta biomechanics and provides a platform for molecular mechanism studies of aortic disease and related drug screening. This aorta smooth muscle-on-a-chip model and human tissue proteomic analysis revealed that impaired mitochondrial dynamics could be a potential therapeutic target for BAV-TAA.Funding:National Key R and D Program of China, National Natural Science Foundation of China, Shanghai Municipal Science and Technology Major Project, Shanghai Science and Technology Commission, and Shanghai Municipal Education Commission.
Clinicopathological value of long non-coding RNA profiles in gastrointestinal stromal tumor
Authors: Zhao Yan , Liu Xinxin , Xiao Keshuai , Wang Liwen , Li Yuping , Kan Mingyun , Jiang Zhiwei 
Published: September 2021

Background
Long non-coding RNAs (lncRNAs) have been implicated in diagnosis and prognosis in various cancers. However, few lncRNA signatures have been established for prediction of gastrointestinal stromal tumors (GIST). We aimed to explore a lncRNA signature profile that associated with clinical relevance by mining data from Gene Expression Ominus (GEO) and Surveillance, Epidemiology, and End Results (SEER) Program.

Methods
Using a lncRNA-mining approach, we performed non-negative matrix factorization (NMF) consensus algorithm in Gastrointestinal stromal tumors (GISTs) cohorts (61 patients from GSE8167 and GSE17743) to cluster LncRNA expression profiles. Comparative markers selection, and Gene Set Enrichment Analysis (GSEA) algorithm were performed between distinct molecular subtypes of GIST. The survival rate of GIST patients from SEER stratified by gender were compared by Kaplan–Meier method and log-rank analysis. lncRNA-mRNA co-expression analysis was performed by Pearson correlation coefficients (PCC) using R package LINC. Somatic copy number alterations of GIST patients (GSE40966) were analyzed via web server GenePattern GISTIC2 algorithm.

Results
A total of four lncRNA molecular subtypes of GIST were identified with distinct biological pathways and clinical characteristics. LncRNA expression profiles well clustered the GIST samples into small size (<5 mm) and large size tumors (>5 mm), which is a fundamental index for GIST malignancy diagnosis. Several lncRNAs with abundant expression (LRRC75A-AS1, HYMAI, NEAT1, XIST and FTX) were closely associated with tumor size, which may suggest to be biomarkers for the GIST malignancy. Particularly, LRRC75A-AS1 was positively associated with tumor diameters and suggested an oncogene in GIST. Co-expression analysis suggested that chromosome region 17p11.2–p12 may contribute to the oncogenic process in malignant GIST. Interestingly, the gender had a strong influence on clustering by lncRNA expression profile. Data from the Surveillance, Epidemiology, and End Results (SEER) Program were further explored and 7983 patients who were diagnosed with GISTs from 1973 to 2014 were enrolled for analysis. The results also showed the favorable prognosis for female patients. The survival rate between male and female with GIST was statistically significant (P < 0.0001). Gene set enrichment analysis (GSEA) indicated distinct pathways between female and male, and malignant GIST was associated with several cancer metabolism and cell cycle associated pathways.

Conclusions
This lncRNAs-based classification for GISTs may provide a molecular classification applicable to individual GIST that has implications to influence lncRNA markers selection and prediction of tumor progression.
In vitro Organogenesis in Cotton (Gossypium spp) for Ex-situ Conservation Issue
Authors: Sinha Marius Guillaume , Cacaï Gilles Habib Todjro , Houngue Jerome Anani , Houédjissin Serge Sètondji , Sossou Thiéris Dassoudo , Ahanhanzo Corneille 
Published: September 2021

Background: Monovarietal cultivation of cotton plant allowed the genetic erosion for traditional cotton varieties that proceed essential traits mainly involved in cotton genetic breeding. These varieties need to be preserved for future used. This study aims to evaluate the effect of gibberellic acid on cotton seed germination and the effect of Benzylaminopurin (BAP), Kinetin (KIN), α-naphthalene acetic acid (NAA) and activated charcoal (CA) on cotton seedlings growth obtained from different type of explants.
Methodology: The seeds of three improved varieties (KET782, ANG956, OKP768) and five local varieties (Q62, Q64, Q85, Q88, Q92) were germinated with different concentration of gibberellic acid (GA3). Different explants were collected from the germinated plantlets and cultivated in different culture media containing plants growth regulators and activated charcoal in different concentration.
Results: We found that Gibberellic Acid activity on cotton seeds germination significantly varied according to the variety and GA3 concentration in the medium. 63.33% germination rate in OKP768 was obtained on the medium containing 0.5 mg/L of GA3 while the medium with 1 mg/l of GA3 gave the highest seed germination in Q85 (75%), Q64 (69.17%), and ANG956 (40.83%). The plantlets regeneration rate varied within the explants in different varieties used. 100%of axillary nodes were regenerated in Q62; Q85 and Q92 varieties while 60% were regenerated with the zygotic embryos in ANG956, and OKP768. Moreover, the medium supplemented with GA3 (1mg/l) + NAA (1 mg/l) induced the greatest number of roots (2.75 roots/plantlet) in the ANG956 and OKP768 varieties. With activated charcoal (10 g/l), ANG956 and OKP768 varieties achieved better performance with respective roots length average of 3.4 cm/plantlet and 2.1 cm/plantlet. The activated charcoal at 10 g/l highly influenced the length of roots with an average of 7.7cm in ANG956 variety.
Implication: The protocol established during this study will be useful for in vitro regeneration and conservation for cotton local varieties.
Public Health Impact of Environmental Pollution in Areas with Gas Flares
Authors: Obi Nkemdilim I. , Bwititi Phillip T. , Nwose Ezekiel U. 
Published: September 2021

Background: A variety of pollutants are discharged during gas flaring and these are detrimental to animals and the environment. These pollutants are linked to a range of adverse health impacts including cancer, neurological, reproductive and developmental effects. Furthermore, some of the pollutants such as sulphur dioxide cause environmental issues including acid rain as well as the production of greenhouse gases and this contributes to climate change. This article evaluates the public health impact of environmental pollution in areas with gas flares.
Methodology: This research followed a mixed method approach of quantitative and qualitative analysis. Descriptive statistics were followed with frequency distribution of respondents to the Likert scaled questions. The nominal knowledge level of respondents was determined from their Likert scaled responses to questions. ANOVA comparisons were made between the subgroups of demographic factors to determine differences in knowledge level. MANOVA was also carried out to determine the influence of educational and social levels as well as duration of stay in the community.
Outcome: Evaluation of the nominal knowledge level of respondents determined from Likert scale shows no statistically significant differences between demographic subgroups. Further, ANOVA of nominal knowledge between educational subgroups shows gradient increase but no statistical difference.
Conclusion: The community has knowledge on the negative impact of gas flaring. This report increases understanding of community awareness about the effects of gas flares on the environment and health.
Age-Related Haematological Variations in Patients with Asymptomatic Malaria in Akure, Ondo State, Nigeria
Authors: Obeagu Emmanuel Ifeanyi , Busari Ayomiposi Ibironke , Uduchi Immaculata Ogochukwu , Ogomaka I. A. , Ibekwe Adaobi Maryann , Vincent C. C. N. , Chijioke Udunma Olive , Okafor Chukwuma J. , Okoroiwu Henshaw U. , Adike Calista Ndidi 
Published: September 2021

Background: Malaria is a life-threatening infectious disease of widespread burden. Malaria remains a leading communicable disease in the developing countries of the world. It occurs mostly in the tropical and subtropical regions and accounts for considerable morbidity and death. Malaria which is liable for a major amount of mortalities in endemic countries has been revealed to have both direct and indirect impacts on the haematologicalparameters.The study was done to compare the levels of haematological parameters of asymptomatic malaria patients based on age groups.
Methods: The study is a cross-sectional study among asymptomatic malaria patients based on age groups. This study was conducted in Oda Road area of Akure, Ondo State. Two hundred (200) subjects were recruited for this study with each group comprising of 100 subjects for patients with asymptomatic malaria for the 2 age groups (16-30 years and 31-65 years). The data were presented in tables and as mean ± standard deviation and analyzed using student-test for parametric data and chi-square for non parametric data by statistical packages for social sciences (SPSS, Version 20.0) and level of significance set at as p≤ 0.05.
Results: The results showed that subjects on age group 16-30 years were 100(50%) comprising of 50 males (25%) and 50 females (25). Also age group 31-65 years has 100 subjects (50%) comprising of 50 males (25%) and 50 females (25).The results showed significant difference in MCV (p=0.008), MCH (p=0.024) and no significant difference in PCV (p=0.675), WBC (p= 0.224), LYM (p=0.109), GRAN (p=0.061), MID (p=0.066), RBC (p=0.119), Hb (p=0.546), MCHC (p=0.262), PLT (p=0.783), when compared between age groups in years (16-30 and 31-65).
Conclusion: The study showed increase in MCV and MCH of asymptomatic malaria patients within the age group of 31-65 years compared to asymptomatic malaria patients on 16-30 years age group. This shows that microcytic hypochromic anaemia may be experienced in asymptomatic malaria patients within the age group of 16-30 years more than in 31-65 years age group.
Unraveling the relevance of the polyadenylation factor EhCFIm25 in Entamoeba histolytica through proteomic analysis
Authors: Salgado‐Martínez América Itzallana , Avila‐Bonilla Rodolfo Gamaliel , Ramírez‐Moreno Esther , Castañón‐Sánchez Carlos Alberto , López‐Camarillo César , Marchat Laurence A. 
Published: September 2021

We recently reported that silencing of the polyadenylation factor EhCFIm25 in Entamoeba histolytica, the protozoan which causes human amoebiasis, affects trophozoite proliferation, death, and virulence, suggesting that EhCFIm25 may have potential as a new biochemical target. Here, we performed a shotgun proteomic analysis to identify modulated proteins that could explain this phenotype. Data are available via ProteomeXchange with identifier PXD027784. Our results revealed changes in the abundance of 75 proteins. Interestingly, STRING analysis, functional GO‐term annotations, KEGG analyses, and literature review showed that modulated proteins are mainly related to glycolysis and carbon metabolism, cytoskeleton dynamics, and parasite virulence, as well as gene expression and protein modifications. Further studies are needed to confirm the hypotheses emerging from this proteomic analysis, to thereby acquire a comprehensive view of the molecular mechanisms involved.
Modification of the Intermediate Binding Energies on Ni/Ni3N Heterostructure for Enhanced Alkaline Hydrogen Oxidation Reaction
Authors: Su Lixin , Gong Dan , Yao Na , Li Yunbo , Li Zhen , Luo Wei 
Published: September 2021

AbstractDeveloping highly efficient and stable non‐precious metal‐based electrocatalysts for alkaline hydrogen oxidation reaction (HOR) is essential for the commercialization of alkaline exchange membrane fuel cells but remains a big challenge. Here, a simple strategy for constructing the Ni/Ni3N heterostructure electrocatalyst with remarkable catalytic performance toward HOR under alkaline electrolyte is reported. Density functional theory calculations and experimental results reveal that the inter‐regulated d‐band center of interfacial Ni and Ni3N derived from electron transfer from Ni to Ni3N across the interface can lead to the weakened hydrogen binding energy of Ni and strengthened hydroxyl binding energy of Ni3N, which, together with the decreased formation energy of water species, contributes to the outstanding HOR performance.