bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Italian Legislature and International and EU Obligations of Domestic Criminalisation
Authors: Longobardo Marco 
Published: April 2021

Abstract
This article explores the nature and content of international and EU obligations to adopt certain criminal domestic legislation, and the impact that they have on the Italian legislature. In light of relevant international, EU, and domestic law provisions, the article investigates what is required of Italy to implement obligations of domestic criminalisation. It is argued that the Italian legislature is bound to implement obligations of domestic criminalisation both under international law and the Italian constitutional law. The article ends with an overview of the legal consequences that Italy may face for failure to implement international and EU obligations of domestic criminalisation.
Effect of Particle Inertia on the Alignment of Small Ice Crystals in Turbulent Clouds
Authors: Gustavsson K. , Sheikh M. Z. , Naso A. , Pumir A. , Mehlig B. 
Published: April 2021

AbstractSmall nonspherical particles settling in a quiescent fluid tend to orient so that their broad side faces down because this is a stable fixed point of their angular dynamics at small particle Reynolds number. Turbulence randomizes the orientations to some extent, and this affects the reflection patterns of polarized light from turbulent clouds containing ice crystals. An overdamped theory predicts that turbulence-induced fluctuations of the orientation are very small when the settling number Sv (a dimensionless measure of the settling speed) is large. At small Sv, by contrast, the overdamped theory predicts that turbulence randomizes the orientations. This overdamped theory neglects the effect of particle inertia. Therefore, we consider here how particle inertia affects the orientation of small crystals settling in turbulent air. We find that it can significantly increase the orientation variance, even when the Stokes number St (a dimensionless measure of particle inertia) is quite small. We identify different asymptotic parameter regimes where the tilt-angle variance is proportional to different inverse powers of Sv. We estimate parameter values for ice crystals in turbulent clouds and show that they cover several of the identified regimes. The theory predicts how the degree of alignment depends on particle size, shape, and turbulence intensity, and that the strong horizontal alignment of small crystals is only possible when the turbulent energy dissipation is weak, on the order of 1 cm2 s−3 or less.
Subseasonal-to-Seasonal Predictability of Onset Dates of South China Sea Summer Monsoon: A Perspective of Meridional Temperature Gradient
Authors: Liu Boqi , Zhu Congwen 
Published: April 2021

AbstractThe onset of the South China Sea summer monsoon (SCSSM) has traditionally been ascribed to the El Niño–Southern Oscillation (ENSO) on an interannual timescale, but the two do not correspond in some years. The present study applies harmonic analysis on the meridional temperature gradient (MTG) in mid–upper troposphere over South China Sea (SCS) and decomposes the onset process to be a slow-varying seasonal cycle and transient subseasonal component. The ENSO-related air temperature anomaly in the southern SCS provides seasonal predictability of SCSSM onset by a stable and robust relationship between ENSO and MTG seasonal cycle. However, in the northern SCS, the MTG is regulated by an intraseasonal oscillation (ISO) of extratropical air temperature with a significant 10–30-day period. This ISO originates over the western TP, then propagates eastward and gets enhanced by anomalous diabatic heating due to spring rainfall anomaly over South China, as a result of subseasonal thermal forcing of TP. When the ISO arrives to the north of the SCS, it directly changes the tropospheric temperature to modulate the MTG. Meanwhile, the upper-level circulation associated with the ISO alters the meridional potential vorticity advection and pumping effect, followed by the anomalous low-level westerly wind and monsoon convection over the SCS. The SCSSM onset is evidently disrupted from its seasonal cycle when this ISO is more active. Since the independence of its intensity from ENSO, this extratropical ISO over TP and South China provides additional subseasonal predictability of the onset dates of the SCSSM.
Lobectomy Demonstrates Superior Survival Than Segmentectomy for High-Grade Non-Small Cell Lung Cancer: The National Cancer Database Analysis
Authors: Baig Mirza Zain , Razi Syed S. , Muslim Zaid , Weber Joanna F. , Connery Cliff P. , Bhora Faiz Y. 
Published: April 2021

Background Current recommendations for segmentectomy for non-small cell lung cancer (NSCLC) include size ≤2 cm, margins ≥ 2 cm, and no nodal involvement. This study further stratifies the selection criteria for segmentectomy using the National Cancer Database (NCDB). Methods The NCDB was queried for patients with high-grade (poorly/undifferentiated) T1a/b peripheral NSCLC (tumor size ≤2 cm), who underwent either lobectomy or segmentectomy. Patients with pathologic node-positive disease or who received neoadjuvant/adjuvant treatments were excluded. Propensity score analysis was used to adjust for differences in pretreatment characteristics. Results 11 091 patients were included with 10 413 patients (93.9%) treated with lobectomy and 678 patients (6.1%) underwent segmentectomy. In a propensity matched pair analysis of 1282 patients, lobectomy showed significantly improved median survival of 88.48 months vs 68.30 months for segmentectomy, P = .004. On multivariate Cox regression, lobectomy was associated with significantly improved survival (hazard ratio (HR): .81, 95% CI .72-.92, P = .001). Subgroup analysis of propensity score matched patients with a Charlson-Deyo comorbidity score (CDCC) of 0 also demonstrated a trend of improved survival with lobectomy. Discussion Lobectomy may confer significant survival advantage over segmentectomy for high-grade NSCLC (≤2 cm). More work is needed to further stratify various NSCLC histologies with their respective grades allowing more comprehensive selection criteria for segmentectomy.
Using Arterial Pressure Index to Predict Arterial Injuries in Penetrating Trauma to the Upper Extremities
Authors: Tung Lily , Seamon Mark J. , Dauer Elizabeth , Alabi Olamide , Benarroch‐Gampel Jaime , Passman Jesse , Fitzgerald Caitlin , Lobichusky Brone , Mazzei Michael , Rodriguez Wendy , Smith Randi N. 
Published: April 2021

Background Upper extremity (UE) vascular injuries account for 18.4% of all traumatic vascular injuries. Arterial pressure index (API) use in lower extremity injuries to determine the need for further investigations is well established. However, due to collateral circulation in UEs, it is unclear if the same algorithm can be applied. The purpose of this study was to determine if APIs can be used to determine the need for computed tomography angiogram (CTA) in penetrating UE trauma. Methods All adult trauma patients with penetrating UE trauma and APIs from 2006 to 2016 were identified at 3 urban US level 1 trauma centers. Sensitivity, specificity, and positive and negative predictive values of APIs <.9 in detecting UE arterial injuries were calculated. Results During the 11-year study period, 218 patients met our inclusion criteria. Gunshot wounds comprised 76.6% and stab wounds 17.9%. Median injury severity score and API were 9 and 1, respectively. Seventy-two of our patients underwent evaluation with CTA. Of the injuries, the most common were thrombus or occlusion (46.7%), transection (23.1%), and dissection (15.4%), radiographically. Ultimately, 32 patients underwent surgical.
Disposable Coverslip for Rapid Throughput Screening of Malaria Using Attenuated Total Reflection Spectroscopy
Authors: Veettil Thulya Chakkumpulakkal Puthan , Kochan Kamila , Edler Karen J. , De Bank Paul , Heraud Philip , Wood Bayden R. 
Published: April 2021

Malaria is considered to be one of the most catastrophic health issues in the whole world. Vibrational spectroscopy is a rapid, robust, label-free, inexpensive, highly sensitive, nonperturbative, and nondestructive technique with high diagnostic potential for the early detection of disease agents. In particular, the fingerprinting capability of attenuated total reflection spectroscopy is promising as a point-of-care diagnostic tool in resource-limited areas. However, improvements are required to expedite the measurements of biofluids, including the drying procedure and subsequent cleaning of the internal reflection element to enable high throughput successive measurements. As an alternative, we propose using an inexpensive coverslip to reduce the sample preparation time by enabling multiple samples to be collectively dried together under the same temperature and conditions. In conjunction with partial least squares regression, attenuated total reflection spectroscopy was able to detect and quantify the parasitemia with root mean square error of cross-validation and R2 values of 0.177 and 0.985, respectively. Here, we characterize an inexpensive, disposable coverslip for the high throughput screening of malaria parasitic infections and thus demonstrate an alternative approach to direct deposition of the sample onto the internal reflection element.
Settler allies are made, not self-proclaimed: Unsettling conversations for non-Indigenous researchers and educators involved in Indigenous health
Authors: McGuire-Adams Tricia 
Published: April 2021

Background: While many settler allies are eager to help towards the goal of disrupting racism, a clearer understanding of how best to harness this eagerness is required within the field of Indigenous health, a field currently comprised mainly non-Indigenous scholars, researchers and educators. Purpose: Responding to this challenge, this article aims to identify ways of working towards disrupting settler colonialism and addressing racism in all of its manifestations by building settler allyship and adopting an anti-racist lens within the field of Indigenous health. The article describes how to approach building settler allyship by implementing anti-racist acts. Method: By using anti-racist scholarship and showcasing recent public examples of anti-Indigenous racism, the author describes how settler allies can approach developing unsettled, critical and anti-racist conversations with one another and in respectful ways with Indigenous peoples. As many Indigenous peoples continue to identify ongoing racism, there is a need for informed, unsettled, anti-racist allies willing to challenge their own complicity to then take action when anti-Indigenous racism occurs. Actions include critical self-reflection, confronting white supremacy and implementing demonstrably anti-racist acts. Conclusion: Findings provide the basis for amplifying unsettling conversations between engaged settler allies to develop anti-racist ways of fostering and extending relationships with Indigenous people and scholars.
Task-Oriented and Imitation-Oriented Movements in Virtual Reality Exercise Performance and Design
Authors: Chen Ken , Chen Karen B. 
Published: April 2021

Objective This study investigated the influence of game features and practice type on human kinematic and muscular performance in a virtual reality exercise (VRE). Participants demonstrated changes in shoulder flexion angle and muscle activation under different virtual scenarios. Background Conventional VRE studies often compared the outcomes between an experimental group that underwent exercise in VR and a real-world exercise control group, whereas comparisons between VRE programs are lacking. Besides, the attributes of VREs received little attention. Method Thirteen able-bodied participants performed upper extremity exercise movements in immersive VR using a head-mounted display. Participants performed task-oriented and imitation-oriented movements with different game features. Shoulder muscle activity (the deltoid, supraspinatus, and infraspinatus) and shoulder motion were collected. Results Practice type (task-oriented, imitation-oriented) significantly influenced the flexion angle of the shoulder complex ( F(1,11) = 9.53, p = .01), and the muscle activity of the supraspinatus ( F(1,9) = 12.61, p = .006) and the infraspinatus ( F(1,9) = 12.71, p = .006). Game features did not have a statistically significant effect on shoulder flexion angle or shoulder muscles’ activations. Conclusions Compared to imitation-oriented practice, task-oriented practice elicited more intensive shoulder movements and muscular efforts but also induced greater movement variations. Substantial differences across game features levels should be further investigated to have significant effects. Applications This research may help guide the design of future VREs. For strength training or rehabilitation where intensive practice is required, task-oriented practice should be considered; for movement learning where movement consistency is required, imitation oriented practice should be adopted.
Clinical Decision Support Systems in Otolaryngology–Head and Neck Surgery: A State of the Art Review
Authors: Standiford Taylor C. , Farlow Janice L. , Brenner Michael J. , Conte Marisa L. , Terrell Jeffrey E. 
Published: April 2021

ObjectiveTo offer practical, evidence‐informed knowledge on clinical decision support systems (CDSSs) and their utility in improving care and reducing costs in otolaryngology–head and neck surgery. This primer on CDSSs introduces clinicians to both the capabilities and the limitations of this technology, reviews the literature on current state, and seeks to spur further progress in this area.Data SourcesPubMed/MEDLINE, Embase, and Web of Science.Review MethodsScoping review of CDSS literature applicable to otolaryngology clinical practice. Investigators identified articles that incorporated knowledge‐based computerized CDSSs to aid clinicians in decision making and workflow. Data extraction included level of evidence, Osheroff classification of CDSS intervention type, otolaryngology subspecialty or domain, and impact on provider performance or patient outcomes.ConclusionsOf 3191 studies retrieved, 11 articles met formal inclusion criteria. CDSS interventions included guideline or protocols support (n = 8), forms and templates (n = 5), data presentation aids (n = 2), and reactive alerts, reference information, or order sets (all n = 1); 4 studies had multiple interventions. CDSS studies demonstrated effectiveness across diverse domains, including antibiotic stewardship, cancer survivorship, guideline adherence, data capture, cost reduction, and workflow. Implementing CDSSs often involved collaboration with health information technologists.Implications for PracticeWhile the published literature on CDSSs in otolaryngology is finite, CDSS interventions are proliferating in clinical practice, with roles in preventing medical errors, streamlining workflows, and improving adherence to best practices for head and neck disorders. Clinicians may collaborate with information technologists and health systems scientists to develop, implement, and investigate the impact of CDSSs in otolaryngology.
Effect of dual-task training on balance in patients with multiple sclerosis: A systematic review and meta-analysis
Authors: Martino Cinnera Alex , Bisirri Alessio , Leone Enza , Morone Giovanni , Gaeta Angela 
Published: April 2021

Objective: To evaluate the effects of dual-task training on static and dynamic balance in patients with multiple sclerosis. Data sources: PubMed/MEDLINE, EMBASE, Scopus, and PEDro databases were searched from inception to March 1, 2021. Methods: This study was conducted in agreement with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two reviewers assessed studies for inclusion and extracted data. We used the Physiotherapy Evidence Database scale to evaluate the methodological quality and the risk-of-bias. Randomized clinical trial data were pooled for the meta-analysis. The effect sizes and 95% confidence interval (CI) were calculated by random-effect models. Egger regression and Begg-Mazumdar rank correlation test were used for publication bias. Results: A total of 13 studies involving 584 patients (42.3 ± 9 years mean ± SD; 377 females) met the inclusion criteria for the systematic review, while nine were included in the meta-analysis. People who received dual-task training interventions showed significant improvements in the Timed Up & Go test 0.44 [(95% CI = 0.22; 0.65), P-value<0.001], and in the Berg Balance scale 0.46 [(95% CI = 0.07; 0.85), P-value = 0.02]. Low and moderate heterogeneity between the studies was found for the Timed Up & Go test and the Berg Balance scale, respectively. Conclusion: The findings from the current meta-analysis support dual-task training as a beneficial therapy for improving dynamic balance and functional mobility in patients with multiple sclerosis. The limited number of studies that investigated static balance performance after dual-task training do not currently allow us to draw a conclusion about any possible improvements in this ability.
Sexual function in patients with endometriosis: a prospective case–control study in China
Authors: Yang Xiaochun , Xu Xinfen , Lin Lili , Xu Kaihong , Xu Min , Ye Jinying , Shen Xiaoli 
Published: April 2021

Objective Endometriosis is a common disease in women of childbearing age, leading to sexual dysfunction or loss of libido. We aimed to evaluated the effect of endometriosis on women’s sexual function. Methods We performed a prospective case–control study to determine the effect of endometriosis on women’s sexual function using a self-administered questionnaire from September 2017 to August 2018. The simplified Chinese version of the Female Sexual Function Index (FSFI) was used to assess sexual function. Results We found that sexual function of women in the endometriosis group (n=77) in all dimensions was significantly lower compared with that in the control group (n=63). The total FSFI score in patients was 25.5, which tended to be lower than that in the control group (26.7). Sexual arousal, sexual pain, and satisfaction were significantly different between the two groups. Sexual arousal and sexual pain scores were significantly lower in the endometriosis group than in the control group at the ages of 31 to 40 years. Conclusion Women with endometriosis suffer from sexual dysfunction, especially those aged 31 to 40 years. Our findings suggest that the quality of sexual life in this subpopulation needs to be improved.
Home and Neighborhood Context of Falls Among Black and White Older Americans
Authors: Okoye Safiyyah M. , Samuel Laura J. , Fabius Chanee , Mulcahy John , Reider Lisa M. , Szanton Sarah L. , Wolff Jennifer L. 
Published: April 2021

Objectives: To examine social and physical environmental fall-risk factors in a nationally representative sample of community-living older adults overall and by racial group. Methods: We used data from the 2015 and 2016 rounds of the National Health and Aging Trends Study ( n = 5581) linked to census tract measures from the American Community Survey. Recurrent falls are defined as 2+ self-reported falls over 12 months. Results: Older adults with recurrent falls were more likely to have lower education, lower income, financial hardship, live in homes with disorder and disrepair and in neighborhoods without sidewalks, with high social deprivation, and in nonmetropolitan counties. Home disrepair, lack of sidewalks, and residence in a nonmetropolitan county were important fall-risk factors among White older adults only. Financial hardship was an important risk factor among Black older adults. Discussion: Environmental factors are associated with recurrent falls among older Americans and should be incorporated into fall-risk profiles and prevention efforts.
Emerging Markets Redefined: Comprehensive Measurement and Future Prospects
Authors: Hu Biliang , Tang Xing , Yin Lin , Liu Qian 
Published: April 2021

The twenty-first century saw the emerging market countries rise as a cluster, becoming a major force driving the global economic growth and playing an increasingly important role in global governance. The existing definition of emerging market countries is vague and quite one-sided, far from capturing the reality. Based on historical experiences and actual circumstances of developing countries and the basic theories of development economics, this article builds a comprehensive index system comprising the five dimensions of nation-state size, institutional environment, economic growth, socio-economic structure, and development impetus to study 30 countries selected from among the 183 countries (regions) around the world. This provides a new analysis framework and theoretical support for in-depth study of the emerging markets.
How to conduct integrated pharmaceutical care for patients with hand-foot syndrome associated with chemotherapeutic agents and targeted drugs
Authors: Chen Jiexiu , Wang Zhuo 
Published: April 2021

Objective The objective of this article was to offer practical operational process for pharmacists to successfully conduct integrated pharmaceutical care for patients with hand-foot syndrome associated with chemotherapeutic agents and targeted drugs which may facilitate the work of first-line clinical pharmacist. Data sources: A literature review was conducted in March 2020 of Pubmed, Medline, and EMBASE (2010-2020) using terms such as: hand-foot syndrome, hand-foot skin reaction, palmar-plantar erythrodysesthesia, chemotherapeutic agent, and multikinase inhibitor. Appropriate references from selected articles were also used. Data summary: This paper involves 81 articles including review articles, meta-analysis, and clinical trials which focused on every aspect of hand-foot syndrome, such as manifestation, mechanism, occurrence rate, onset time, patient education, self-monitor scale, and management. Studies were thematically divided into four parts (clinical presentation of HFS, risk stratification, initiation of pharmaceutic care, and management of the adverse reaction). Conclusion HFS is one of the common adverse events which was associated with many chemotherapeutic agents and multikinase inhibitor drugs. Although the mechanisms and histopathology may be different, they due share some common clinical manifestations. As part of integrated pharmaceutical care for cancer patients, it is important to conduct patient education about the risk of hand-foot syndrome and basic knowledge about hand-foot syndrome management before initiating anticancer therapy. Once hand-foot syndrome happens, evidence-based management could try. If the hand-foot syndrome is intolerable, dose reduction or discontinuation of the anticancer therapy should be considered.