bluuebunny/crossref_metadata_2025_split huggingface dataset:
INNOVATIVE DEVELOPMENT OF THE COUNTRY AS A DETERMINING FACTOR OF INCREASING NATIONAL COMPETITIVENESS
Authors: Kovpaka Anastasiya 
Published: June 2021

This publication is devoted to highlighting the problem of ensuring the appropriate level of national competitiveness and identifying ways to increase it in today's competitive market environment. In the context of the study, the main reasons for Ukraine's chronic lag in the system of international economic relations were identified, including: irrational use of the country's resource potential, high material consumption, energy-intensive economy, low efficiency of economic reforms, physical and moral depreciation, lack of sufficient funding for research and development, high unemployment and the progressive trend of emigration of scientists, unfavorable investment climate and others.
According to the main factors used by the world community in determining the growth of competitiveness of the economy, three groups of indicators were identified, which are the main competitive advantages in an unstable market economy, namely: factors of production, income and investment and innovation potential.
It was possible to analyze the indicators of the human development index and the level of competitiveness of the country on the basis of data from the International Institute for Development Management and the UNDP Report. Indicators of Ukraine in the ranking of innovative economies of the world helped to determine the main causes of technological backwardness of the country, based on which the main directions of innovation development were proposed: state support of science-intensive production, reorientation of raw materials orientation of Ukraine's exports to conduct innovative business.
Attracting investment in technology development and innovative development of enterprises, stimulating the production of high-tech products and compliance with quality standards are the most important steps towards the reorientation of Ukraine's economy to an innovative model of socio-economic growth.
IMPLEMENTATION OF QUALITY MANAGEMENT SYSTEM FOR PRODUCTS AND SERVICES IN UKRAINE
Authors: Nikolaienko Serhii , Vikarchuk Olga , Lewandowska Hanna 
Published: June 2021

The problem stemming from the implementation of quality management system within enterprises is presented in this article. The quality of products is one of the most important criteria of enterprise’s performance. Thus, its improvement has significant impact on the growth of production efficiency and, therefore, economic growth. The functions of quality management system, such as quality planning, organizing work and encouraging employees to ensure product quality, monitoring and evaluating product quality and managing product quality, are discussed in this article.
Ten groups of product quality indicators are distinguished according to its characteristics. It is identified that controlling is an essential function in the quality management process. The following controlling types facilitate the process of controlling: input control, ongoing control, operational control, acceptance control and inspection control. Nevertheless, the most effective method of quality assurance is the quality management system based on the international standards of the ISO 9000 series.
Development of assessment indicators system for production performance and evaluation plays an important role in quality management. Based on the analysis of the indicators, it can be concluded that quality management is a coordinated management function related to the operation of the enterprise. Eight principles of quality management system are considered as well as factors which negatively influence the effectiveness and efficiency of the quality management system are identified in this article.
ANALISIS USAHA BUDIDAYA KEPITING BAKAU UNTUK MENINGKATKAN PENDAPATAN PEMBUDIDAYA TAMBAK DI KABUPATEN PANGKEP
Authors: Fardiyah Vivi Imrona , Tantu A. Gusti , Mulyani Sri 
Published: June 2021

Penelitian ini bertujuan untuk menganalisis pengaruh penggunaan input produksi terhadap hasil produksi, juga mengestimasi tingkat efisiensi penggunaan input produksi pada budidaya penggemukan kepiting bakau di Kabupaten Pangkep. Pada penelitian ini, teknik pengambilan sampel adalah sensus, yaitu petani pembudidaya penggemukan kepiting sebagai responden. Analisis data menggunakan Stochastic Production Frontier yang penyelesaiannya dengan bantuan program LIMDEP versi 6. Hasil estimasi menunjukkan dengan menggunakan fungsi produksi frontier bahwa variabel bebas yang signifikan berpengaruh positif terhadap produksi kepiting adalah luas keramba, jumlah benih dan jumlah pakan. Analisis terhadap Efisiensi Teknis (ET) rata-rata sebesar 0,94986. nilai tersebut dapat dikatakan sebagai prestasi atas kinerja penggunaan input produksi yang sangat memuaskan (mendekati 1), namun disisi lain kesempatan untuk melakukan pengembangan relatif sempit sehingga perlu upaya ekstensifikasi. Nilai R/C rasio sebesar 1,9516, artinya bahwa budidaya penggemukan kepiting bakau masih menguntungkan sehingga layak untuk dikembangkan.
His study aimed to analyze the effect of the use of inputs to production, also estimate the efficiency of use of production inputs in the cultivation of mangrove crab fattening in Pangkep. In this study, the sampling technique is the census that farmers crab fattening farmers as respondents. Analysis of data using Stochastic Production Frontier settlement with the help of the program LIMDEP version 6. The estimation results show using frontier production function that the independent variables were significant positive effect on the production of crab is spacious cages, seed number and amount of feed. Analysis of the Technical Efficiency (ET) by an average of 0.94986. The value can be regarded as the achievement of the performance use of production inputs very satisfying (approaching 1), but on the other hand the opportunity to develop a relatively narrow so that extending the necessary efforts. Rated R / C ratio of 1.9516, it means that the cultivation of mangrove crab fattening still profitable so as to develop.
PENINGKATAN PERTUMBUHAN DAN KECERAHAN WARNA IKAN MAS KOI CYPRINUS CARPIO DENGAN PEMANFAATAN TEPUNG WORTEL DALAM PAKAN
Authors: Budi Sutia , Mardiana Mardiana 
Published: June 2021

Ikan Hias jenis ikan Mas Koi Cyprinus carpio memiliki daya tarik pada warna yang dimunculkan dari tubuhnya. Tepung Wortel memiliki pigmen karotenoid, asam askorbat, flavenoid, phenol asit dan lutein. Penelitian ini bertujuan untuk mengevaluasi pertumbuhan dan kecerahan warna ikan Mas Koi Cyprinus carpio melalui pemberian tepung wortel dalam pakan dengan dosis yang berbeda. Parameter peubah yang diukur berupa perubahan warna dengan menggunakan scoring melalui metode modifikasi TCF dan pertumbuhan mutlak. Wadah penelitian menggunakan toples transparan 7 L, dengan volume air sebanyak 5 L per wadah. Hewan uji yang digunakan adalah ikan Mas dengan kepadatan 1 ekor per wadah. Perlakuan yang di uji adalah berbagai dosis tepung wortel dalam pakan, yakni A = 0 % , B = 5 %, C = 10 % dan D = 15 %, dengan masing – masing 3 kali ulangan. Hasil penelitian menunjukkan bahwa perlakuan berbagai konsentrasi tepung wortel dalam pakan memberikan pengaruh terhadap pertumuhan dan kecerahan warna tubuh ikan Mas Koi..
Ornamental fish, the type of Koi carp, Cyprinus carpio, has an attraction to the color that emerges from its body. Carrot flour has carotenoid pigments, ascorbic acid, flavenoid, phenol acetate and lutein. This study aimed to evaluate the growth and color brightness of the Koi carp Cyprinus carpio through the application of carrot flour in the feed with different doses. Parameters measured in the form of color changes using scoring through the modified TCF method and absolute growth. The research container used a 7 L transparent jar, with a volume of 5 L of water per container. The test animals used were goldfish with a density of 1 fish per container. The treatments tested were various doses of carrot flour in the feed, namely A = 0%, B = 5%, C = 10% and D = 15%, with 3 replicates each. The results showed that the treatment of various concentrations of carrot flour in the feed had an effect on the growth and brightness of the body color of Mas Koi fish..
SIGNIFICANCE OF SEROLOGICAL MONITORING FOR POULTRY ORNITOBACTERIOSIS THERAPY
Authors: Avdosieva I. K. , Chajkovska O. I. , Basarab O. B. , Regenchuk V. V. 
Published: June 2021

One of the main problems of poultry diseases is respiratory diseases. Among them a special place is occupied by ornithobacteriosis (ORT). Losses from ORT consist of: direct losses as a result of the disease - death of chickens, increased culling due to lameness, low live weight gain (up to 40%), reduction of carcass categories, reduction of egg production by 6-20%; indirect losses associated with the immune-suppressive effect of ornithobacteria, which increase the risk of other infections and prevent the formation of post-vaccination immunity. The diagnosis is established on the basis of epizootological data, clinical signs, pathological and anatomical changes, bacteriological and serological tests, positive bioassay. In most cases, infections caused by ornithobacteria are not diagnosed in time, the pathogen is difficult to isolate due to complications of other pathogens, or because experts are currently insufficiently aware of the ability of ORT to cause disease. ORT can be isolated by bacteriological method only at an early stage of the disease. The most relevant method of diagnosis is PCR. The advantage of the method is not only the isolation of DNA of individual cells of the pathogen in the sample, but also the ability to detect all serotypes. In addition, PCR is a successful diagnosis in the detection of ORT nucleic acid not only in tissue samples, but also in feces, eggs, dust, which is important for timely diagnosis. Enzyme-linked immunosorbent assay (ELISA) is used to control the presence of ornithobacteriosis in bird. The presence of antibodies to this pathogen in poultry of many species indicates its wide circulation.
Thus, when conducting serological monitoring of blood serum from different age groups of broilers aged 1-44 days, the percentage of positive samples ranged from 40 to 100, which indicates the circulation of the field strain of the pathogen ornithobacteriosis. The percentage of positive serum from broilers to ORT was: from 1 to 5 days - from 88 to 50, from 6 to 10 days serum were negative, while at 17, 21 days and from 32 days to the end of cultivation (44 days) – 100 %. The percentage of positive batches at the end of fattening ranged from 42-53 days in the range from 75 to 100%, indicating the circulation of the field strain of the ornithobacteriosis pathogen antibiotic therapy against this disease.
SETTING OF PARAMETERS OF ACUTE AND SUBACUTE TOXICITY OF THE POWDER BASED ON IODOFORM
Authors: Kotsyumbas I. Ya. , Patereha I. P. , Kushnir V. I. , Martynyk S. Yа. , Zhyla M. I. , Chudyak М. М. 
Published: June 2021

The article presents the results of establishing the parameters of acute and subacute toxicity of the powder based on iodoform.
Determination of acute toxicity parameters of the drug "Iodomin" were performed on 30 white mice 2-3 months of age, weighing 20-23 g and 30 white rats, aged 2-3 months, weighing 170-190 g. The drug was administered intragastrically, once, pre-dissolved in water. As a result of studies to determine acute toxicity by oral administration, it was found that, after administration of the drug in doses of 1000, 3000 and 5000 mg/kg, all animals remained alive. No changes in the clinical condition of the animals of the experimental groups were observed. The DL50 of ''Iodomin" powder is more than 5000 mg/kg. In conducted studies did not reveal the death of animals, respectively, the tested drug belongs to the IV class of toxicity (low toxicity).
Studies on the determination of acute dermal toxicity of Iodomine were performed in accordance with the requirements of OECD № 402 (Acute Dermal Toxicity: Fixed Dose Procedure, 2017). Studies have shown that skin application of powder "Iodomin" at a dose of 2000 mg/kg body weight did not cause death, appearance of toxic effects. According to GHS the drug belongs to the 5th category.
In the study of subacute toxicity, the drug was administered intragastrically, daily, pre-dissolved in water. On the 4th day of the experiment, in two experimental groups was a significant decrease in heart weight, which may be associated with functional load, and in group 2 (5-fold from therapeutic dose), along with that was a significant increase in liver mass, decreased concentration hemoglobin in the erythrocyte, creatinine in the blood, increased ALT activity.
To determine the harmful effects of Iodomin powder on the mucous membrane of the eye were used 3 rabbits, to which the drug was administered in the amount of 2 drops in the conjunctival sac of the left eye. The harmful effect of the tested substance on the mucous membrane of the eyes was assessed by the appearance of hyperemia, edema and secretions according to the scoring system. When applying the suspension on the mucous membrane of the eye, it was found out, that after 24-48 hours the drug does not cause irritation. Also was found that the studied agent does not cause hyperemia, edema and changes in blood vessels. It's established that the powder "Iodomin" does not cause harmful effects on the mucous membranes of the eye.
DIFFERENT LEVELS OF MIXED-LIGANDE COMPLEXES OF ZINC, MANGANESE AND COBALT IN THE FEEDING OF HIGHLYPRODUCTIVE COWS UKRAINIAN BLACK-SPOTTED DAIRY BREED THE FIRST LACTATION AND THEIR IMPACT ON FEED CONSUMPTION, PRODUCTIVITY, REPRODUCTIVE FUNCTION
Authors: Kropyvka Yu. G. , Bomko V. S. 
Published: June 2021

The results of studying the influence of different levels of mixed-ligand complexes of Zinc, Manganese and Cobalt in feeding high-lyproductive cows Ukrainian Black-Spotted dairy breed on feed consumption, milk productivity for the first 100 days of lactation, reproductive function and hematological parameters are presented.
It was found that on average during the first 100 days of lactation experimental cows consumed 52.6-54.2 kg of feed mixture day and most of it was eaten by cows of the 4th experimental group.
The best results in milk productivity (milk yield and fat and protein content) were obtained from cows of the 4th experimental group, which received rations with mixed-ligand complexes of Zinc, Manganese and Cobalt, the concentration of which in 1 kg of DM feed mixture, mg: Zinc - 48.6; Manganese - 48.6 and Cobalt - 0.62.
Feed consumption per 1 kg of milk was the lowest in the 4th experimental group and amounted to 7.42 MJ of metabolic energy against 7.74 MJ of metabolic energy in the 1st control group and 7.19-7.48 MJ of metabolic energy in other experimental groups.
Different levels of mixed-ligand complexes of Zinc, Manganese and Cobalt in feed mixtures of dry cows in the last 30 days of gestation caused a difference in live weight of calves at birth and had a positive effect on the reproductive functions of experimental cows. 2.1 fertilizations were required for one fruitful insemination of each cow in the 1st control group, 1.8 in the 2nd; 3rd - 1.6; 4th - 1.5 and 5th - 1.7.
Analysis of hematological parameters of experimental cows shows that different levels of mixed-ligand complexes of Zinc, Manganese and Cobalt in concentrated feeds have a positive effect on the body of lactating cows, which, in turn, improves their milk productivity and especially reproductive functions.
MICROBIOLOGICAL MONITORING OF HONEY
Authors: Kushnir I. M. , Semen I. S. , Kolodiy G. V. , Murska S. D. , Kushnir V. I. , Berbeka U. Z. 
Published: June 2021

The article presents the results of determination the microbiological parameters of honey as one of the important factors which influence on the quality and safety of food.. Therefore. It was determined the quantitative and qualitative composition of honey microflora from different regions of Ukraine and also was studied the sensitivity of isolated cultures to antibiotics. The main microbiological risks are the increased level of mesophilic anaerobic facultative anaerobic microorganisms, contamination of honey with pathogenic and opportunistic microorganisms (Coliforms, Staphylococcus aureus, Salmonella, Clostridium perfringens, B. cereus) and microscopic fungi. It was found that total bacteria count was from 70 to 6,9 · 103 CFU/g. Molds were detected in 35,2 % cases, and their amount was from 50 to 320 CFU/g. Yeast-like fungi were detected in 29,4 % of samples and their amount was from 80 to 2.8 · 103 CFU/g. When identifying, the isolated microorganisms in the studied samples of honey was found microorganisms of the genus Staphylococcus, in particular, S aureus, S. vitulinis, S. simulans, S. hominis, S. cohni and also Sphingomonas paucimobilis and Streptomices spp.
In the study of washes from hives found that total bacteria count was from 2,8 · 104 to 1,4 · 106, mold fungi from 6,9 · 103 to 6,9 · 104 CFU/cm3, yeast-like fungi from 1,4 · 102 to 2,6 · 102 CFU/cm3. In results of conducted studies was found that staphylococci of S. simulans, S. hominis, S. cohni and S. aureus were not sensitive or poorly sensitive to streptomycin, amoxicillin and cephalexin, except for the strain S. vitulinis.
The analysis of the results of monitoring of honey by microbiological indicators revealed negative trends in general microbial contamination and contamination by certain types of microorganisms, in particular Coliforms, staphylococci and microscopic fungi.
To prevent the emergence of microbiological risks, it is necessary to establish microbiological criteria for safety of honey, to develop methodological approaches to the bacteriological studies of honey and bees products.
DEVELOPMENT OF METHODS FOR QUANTITATIVE DETERMINATION OF ALBENDAZOLE AND ITS METABOLITES IN BIOLOGICAL TISSUES USING HPLC / FLD
Authors: Melikyan S. , Biront N. , Venyatynska O. , Pazderska O. , Mysko G. , Yanovych D. 
Published: June 2021

This manuscript presents the results of developed method is intended for clinical and pharmaceutical studies of veterinary drugs based on the active substances albendazole ([5-(propylthio)-1H-benzimidazol-2yl]carbamic acid methyl ester) and its main metabolites, albendazole sulfoxide, albendazole sulfone, and albendazole-2- aminosulfone in sheep muscles. Tissue samples were made alkaline with sodium carbonate, extracted twice with acetonitrile and degreased with hexane. The extracts are further purified using a series of liquid-liquid extraction and solid phase extraction. After concentration and drying, the dry residue was recovered in the mobile phase. Separation was performed on an inverted phase Acclaim 120 C18 column using acetonitrile and phosphate buffer as the mobile phase. The gradient mode of eluents was used during 12 min at a flow rate of 1,8 ml/min. The peak retention time of albendazole 2-aminosulfoam is 3,0 min, albendazole sulfoxide is 3,9 min, albendazole sulfone is 4,8 min, and the retention time of albendazole peak is 6,6 min. The specificity of the analytical method was checked by comparing the chromatographic separation of a sample of muscle tissue enriched with a standard solution of a mixture of albendazole and its metabolites at the level of MDR (100 μg/kg) and a sample of muscle tissue placebo. The validation parameters of the method “recovery” and “coefficient of variation” were considered in accordance with the criteria of Council Directive 2002/657/EC. The procedure of sample preparation of fortified tissues to construct calibration graphs is described in the manuscript. The mean recovery from fortified muscle tissue in the range of 50-150 μg/kg albendazole, albendazole sulfoxide, albendazole sulfone and albendazole 2-aminosulfon was 100.2; 100.9; 100.7 and 100.2%, respectively. The average coefficient of variation for each compound was ≤ 10%.
The method is linear in the concentration range of 25.0 - 200.0 μg/kg of each analyte. The results obtained in the study of the linearity of this technique were used to estimate the correctness and convergence. The accuracy of the measurements was evaluated by examining the known amounts of analytes added to the control muscle tissue. Recovery data are acceptable because they are within ± 10% of the target value. The method has sufficient convergence (accuracy). The evaluation of the intermediate accuracy of albendazole and its metabolites was assessed on three different days of analysis. The limit of detection for albendasole is 0.4 μg/kg. The average CV for each compound was <10%.
The procedure was confirmed and then applied to determination albendazole and its metabolites in the sheep muscle tissue obtained after feeding animals with the veterinary drug albendazole. The HPLC/FLD method can be used for withdrawal time albendazole and its metabolites.
GLOBIGEN JUMP START APPLICATION WITHIN THE PRE-STARTER FEED TO THE POST-WAENING PIGLETS
Authors: Prudius T. Y. , Hutsol A. V. , Hutsol N. V. , Mysenko O. O. 
Published: June 2021

Balanced addition of essential amino acids, vitamins and minerals, easily digestible proteins, namely proteins of animal origin is an important factor for efficient feeding and pigs performance, that leads to a systematic search for new solutions when using feed additives. They provide digestibility, better absorbtion of protein, vitamins, minerals and other nutrients. Such supplements include blood plasma, meat and bone meal, fish meal and others.
Besides fishmeal, other protein groups are dangerous in relation to African swine fever. Furthermore blood plasma additionally to the protein group contains immunoglobulins that can passively affect the immune system of piglets, An alternative to blood plasma is the animal nutrition supplement Globigen Jump Start, which is made from chicken eggs, containing essential and replaceable amino acids with a high percentage of absorption. Another important factor is the presence of specific IgY immuno-globulins, which being ingested have a negative effect on the pathogenic intestinal microflora, namely viruses, bacteria and cryptosporidium. Knowledge of the feed additive Globigen Jump Start effect gave impetus to the study of its effect on the piglets’ performance during the stressful period after weaning.
The objective of the work was evaluation of the effect of the Globigen Jump Start fed within the pre-starter feed on the productive characteristics of post-weaning piglets. Based on the obtained research results, the best ones were shown in the experimental group, which was fed compound feed containing Globigen Jump Start in the amount of 2 kg / t of compound feed. It was found that at the end of the experiment, the weight of piglets in the control group was 19.2 kg, and in the experimental group - 21.0 kg, which is 1.8 kg or 9.4% more comparing to the control.