bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Significance of Insulin Peptide–specific Interferon-γ–related Immune Responses in Ketosis-prone Type 2 Diabetes
Authors: Satomura Atsushi , Oikawa Yoichi , Haisa Akifumi , Suzuki Seiya , Nakanishi Shunpei , Katsuki Takeshi , Shimada Akira 
Published: December 2021

Abstract

Context
Unprovoked A−β+ ketosis-prone type 2 diabetes (KPD) is characterized by the sudden onset of diabetic ketosis/ketoacidosis (DK/DKA) without precipitating factors, negative anti-islet autoantibodies (“A−”), and preservation of β-cell function (“β+”) after recovery from DKA. Although this phenotype often appears with acute hyperglycemia and DK/DKA just like acute-onset type 1 diabetes (AT1D), the involvement of anti-islet immune responses remains unknown.

Objective
We sought to clarify the immunological role of insulin-associated molecules in unprovoked A−β+ KPD.

Methods
In this cross-sectional study, blood samples from 75 participants (42 with AT1D and 33 with KPD) were evaluated for interferon (IFN)-γ–secreting peripheral blood mononuclear cells (PBMCs) reactive to 4 insulin B-chain amino acid 9-23–related peptides (B:9-23rPep) using an enzyme-linked immunospot (ELISpot) assay.

Results
Overall, 36.4% (12/33) of KPD participants showed positive IFN-γ ELISpot assay results; the positivity rate in KPD was similar to that in AT1D (38.1%; 16/42) and statistically significantly higher than the previously reported rate in type 2 diabetes (8%; 2/25; P &lt; .0167). Moreover, B:9-23rPep-specific IFN-γ–producing PBMC frequency was negatively correlated with age and ad lib serum C-peptide levels in all KPD participants and positively correlated with glycated hemoglobin A1c level in KPD participants with positive IFN-γ ELISpot results.

Conclusion
These findings suggest the involvement of B:9-23rPep–specific IFN-γ–related immunoreactivity in the pathophysiology of some unprovoked A−β+ KPD. Moreover, increased immunoreactivity may reflect transiently decreased β-cell function and increased disease activity at the onset of DK/DKA, thereby playing a key role in DK/DKA development in this KPD phenotype.
Caracterização das raízes do polinômio do terceiro grau e alguns resultados
Authors: Yamaoka Luís Cláudio 
Published: December 2021

Neste artigo apresentamos um procedimento para caracterizar as raízes do polinômio do 3º grau $f \in \R[x]$ recorrendo a fatos do Cálculo. Ademais, impondo condições aos coeficientes de $f \in \R[x]$, estabelecemos uma comparação entre a parte real de suas raízes complexas não reais conjugadas e o(s) ponto(s) crítico(s) de $\mathbf{f}: \R \rightarrow \R$.
Classe Equivariante de Chern-Schwartz-MacPherson
Authors: Monteiro Amanda , Grulha Júnior Nivaldo De Góes 
Published: December 2021

Para uma variedade algébrica complexa singular existem várias definições de classes características possíveis. A classe de Chern-Schwartz-MacPherson é uma delas. R. MacPherson construiu a classe provando a existência de uma única transformação natural do grupo abeliano das funções construtíveis sobre X para o grupo de homologia tal que, se X é não-singular, então C∗(1X) coincide com a classe de Chern usual. Independentemente, M.-H. Schwartz introduziu classes de obstrução para a extensão de campos vetoriais radiais sobre X, e foi mostrado que essas definições são equivalentes, a partir de então esta classe tem sido chamada de classe de Chern-Schwartz-MacPherson.Neste estudo, apresentamos uma G-versão da classe de Chern-Schwartz-MacPherson para as G-variedades algébricas.
O IMPACTO DE RAÇA E GÊNERO NO PERCURSO ACADÊMICO: INTERSECCIONALIDADE, EDUCAÇÃO E REPRESENTATIVIDADE
Authors: Hilário Rosangela Aparecida 
Published: December 2021

Este artigo é resultado de uma pesquisa, desenvolvida entre os meses de agosto de 2019 e junho de 2020 na cidade de Porto Velho, para verificar os impactos de raça e gênero no percurso acadêmico. Tendo como referência teórica os conceitos de interseccionalidade e decolonialidade, tem por objetivo analisar o quanto os percursos de ascensão das mulheres pretas na academia são influenciados pelas categorias de marcação social raça, gênero e classe. Para tal, as análises foram pautadas a partir das narrativas de uma professora preta, em seu percurso desde os tempos de estudante até a participar como única mulher titulada da fundação da Universidade Federal de Rondônia, ocupar espaços de poder primeiro como professora, depois a função de Chefe de Departamento de Educação de Porto Velho da Universidade Federal de Rondônia, decana do Conselho Superior Universitário. Em consonância a estas narrativas, como resultados destas incursões, verificou-se como as avenidas identitárias revelam quem é atingido por seus movimentos e como as políticas públicas para inclusão do povo preto em espaços de poder se movimenta na academia.
Currículos de licenciatura em História de duas universidades públicas brasileiras e a lei 10.639/2003: silêncios, disputas e resistência
Authors: Silva Marcos Antonio Batista , Araújo Danielle Pereira de 
Published: December 2021

Este artigo propõem uma análise sociopolítica das disputas, resistências e silenciamentos no que tange a implementação da Lei 10.639/2003 e suas diretrizes nos currículos dos cursos de licenciatura em história na Universidade Federal do Rio de Janeiro e da Universidade da Integração Internacional da Lusofonia Afro-Brasileira. Partimos das contribuições da teoria crítica de raça e racismo e da análise de discurso para compreender de que forma as matrizes curriculares das licenciaturas em história refletem a discussão sobre a incorporação da valorização da história e cultura afro-brasileira e africana nos currículos. A análise aponta que a implementação da Lei tem deixado evidente que os currículos são espaços em disputas, tensionamentos e silenciamentos em relação às narrativas da população negra brasileira e africana.
FIGURAÇÕES FEMININAS SUBVERTIDAS NO CONTO SURVIVAL SHIP (1951) DE JUDITH MERRIL: FICÇÃO CIENTÍFICA E GÊNERO EM NEGOCIAÇÃO
Authors: Boiko da Rosa Janis Caroline 
Published: December 2021

Survival Ship (1951), texto de Judith Merril, narra a história do lançamento de uma espaçonave colonizadora comandada por mulheres. O conto foi publicado em um momento de virada conservadora, em que o papel da mulher na casa era continuamente enfatizado, de modo que a publicação de imagens femininas em contradição com o discurso oficial nos leva a questionar como a autora manejou tais figurações. Assim sendo, este trabalho busca entender como Judith Merril subverte narrativas e figuras típicas dos discursos oficiais e da ficção científica para criar um conto que desafia padrões de representação de gênero. Para tanto, partiremos de uma concepção de gênero e ficção científica como códigos linguísticos e pensaremos a subversão como uma forma de inversão de significado e transgressão de narrativas culturalmente disponíveis para tratar das categorias homem e mulher.
Inclusion Complex of Fexofenadine Hydrochloride with Cyclodextrins
Authors: Huremovic Melita , Srabovic Majda , Salihovic Mirsada , Pehlic Ekrem 
Published: December 2021

<p>Fexofenadine hydrochloride (FFN), (±)-4-[1-hydroxy-4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl] α,α-dimethylbenzeneacetic acid hydrochloride, is a second-generation antihistamine that is used to treat allergies. The drug is highly hydrophobic and slightly soluble in water. Cyclodextrins are widely used to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules.Cyclodextrins can molecularly encapsulate various drugs into their hydrophobic cavity without forming any covalent bonds. Cyclodextrin (CDs), especially ß-Cyclodextrin (ß-CD), are widely used in the pharmaceutical field due to its ability to stabilize drug molecules and taste masking purposes.<strong> </strong></p><p>The phase solubility study was performed according to the method of Higuchi and Connors by adding the fexofenadine hydrochloride in excess to different concentrations of cyclodextrin solutions. Phase solubility study records show that the stability constant and complex stoichiometry of FFN-CD complexes increases linearly with CD concentration. Also, an increase in the concentration of β-cyclodextrin leads to an increase in the aqueous solubility of FFN. Complexes were analyzed by UV-VIS spectroscopy using the calibration curve of FFN. Also, UV-VIS spectra indicate a bathochromic shift which proves that complex formation has occurred.</p><p>Solid inclusion complexes of fexofenadine/β-cyclodextrin and its derivatives were prepared at the molar ratios of 1:1 by the physical mixing method. Characterization of the complexes was performed by using infrared spectroscopy. </p>
Art, Creativity and Automation. From Charters to Shared 3D Visualization Practices
Authors: Opgenhaffen Loes , Lami Martina Revello , Mickleburgh Hayley 
Published: December 2021

Abstract
In this study, we introduce the themes of the Special Issue on Art, Creativity and Automation. Sharing 3D Visualization Practices in Archaeology, and present the most important outcomes of a roundtable session involving prominent researchers in the field, organized by the authors during the Archon Winter School in February 2020. By assessing the diversity of research aims, artistic projects, creative practices and technology used in the contributions to the Special Issue, and drawing on the thoughts and perspectives generated during the roundtable discussion, we seek to identify shared challenges within the community of visualizers which could ultimately pave the way to shared practices. In this light, we assess whether established charters and guidelines are still relevant in a now matured digital archaeology, where visualization techniques have attained a central position in archaeological knowledge production. Although parts of the guidelines have become common practice, the remainder did not keep up with the fast pace of development of digital practice and its current fundamental role in archaeology, and as a result some of the guidelines risk becoming obstructive in archaeological creative practice.
Effect of different thawing methods on quality properties of stuffed pasta (manti)
Authors: Gökmen Süleyman 
Published: December 2021

Stuffed pasta or ‘manti’ is a traditional food consumed fondly in Turkey. For consumption, it is produced as fresh, frozen or dried manti. Frozen manti is cooked directly without thawing. The present study investigated the effects of different thawing processes on physicochemical properties and sensory qualities of frozen stuffed pasta (manti). The following five thawing processes were used individually: (1) infrared, (2) microwave (3) infrared-assisted microwave, (4) dry hot air and (5) running water thawing. The storing temperatures of manti found in the market were 10°C and 24.5°C. Consequently, manti samples were thawed up to these temperatures. It was determined that the shortest thawing period (20 sec) was that of infrared-assisted microwave process. The longest process was dry hot-air thawing (420 sec) in manti samples that were thawed until refrigerator (+4°C) and room temperatures (24.5°C). Thawing methods did not change pH, moisture values and weight gain (p > 0.05). It was found that sensory qualities and amount of dry matter passing into the water of samples were different (p < 0.05). It was concluded that thawing was necessary for frozen manti, and the best method was microwave thawing.
El costo de la vivienda X el costo del transporte y el acceso al derecho a la ciudad
Authors: Ribeiro Edson Leite , Silveira José Augusto Ribeiro da 
Published: December 2021

Este estudio aborda el dilema del acceso al derecho a la vivienda urbana, entendido como no restringido al derecho a la vivienda, sino al acceso a oportunidades y ofertas de bienes y servicios públicos y privados que definen la necesidad de vivienda urbana en el contexto brasileño. En ejercicio de este derecho, especialmente para los grupos de ingresos matriculados hasta el 4º decil. Bajos ingresos, las dificultades para elegir entre la carga de la accesibilidad al derecho a la vivienda, la carga (pérdida) de oportunidades y accesibilidad a los componentes externos del derecho a la vivienda y el (creciente) costo de la movilidad y accesibilidad a el derecho a la ciudad, resultaron ser bastante dramáticos, constituyendo una verdadera «elección de Sofía» parafraseando la conocida trama de Styron
Subtask A: User perspective and requirements - A.3 Personas
Authors: Szybinska Matusiak Barbara , Martyniuk-Peczek Justyna , Sibilio Sergio , Naves Claudia , Amorim David , Scorpio David Amorim, Michelangelo , Ciampi Giovanni , Nazari Marzieh , Sokol Natalia , Kurek Julia , Waczynska Marta , Giraldo Vasquez Natalia , Resende Kanno Julia 
Published: December 2021

The consumption of energy for lighting in buildings depends very much on the way people interact with the build environment. In this study the following building types were studied, office, school, university, commercial and industry buildings. For each building type typical user groups were identified. Then, Personas have been created for each group. As opposed to describing users with numbers and statistics, a single Persona reflects a group and is presented with a narrative. The Persona has a name, a family and living conditions that are representative for the group, also her/his values and interests are not uncommon. The Personas “typical day” includes a time schedule typical for the group. Visual conditions are common for the group, but some specific challenges connected to the visual conditions that may occur in the group are also mentioned.
Review of new systems and trends
Authors: Unzeta Bruno Bueno , de Boer Jan , Delvaeye Ruben , Derengowski Nikodem , Deroisy Bertrand , Fontoynont Marc , Neves Pimenta Daniel , Reinhold Per , Stoffer Sophie , Weitlaner Robert 
Published: December 2021

Innovative and integrative lighting solutions are a rapidly developing trend among BMS manufacturers. They are being implemented in various systems from industry-leading firms, however they are met with a challenge of finding the best possible compromise between occupant expectations and optimization of building operation.
THE IMPORTANCE OF MEANING IN ARABIC TEXTBOOK TRANSLATION
Authors: Hikmawati Hanifah 
Published: December 2021

<pre><a name="_Hlk89781071"></a><span class="y2iqfc"><span lang="EN-US">The translation process includes transferring the source language into the target language with the intention of knowing the meaning. When meaning is expressed to the reader, then all information, insight, and knowledge can also be understood. As in textbooks, knowledge conveyed through texts in it of course have references from foreign languages, including Arabic. Therefore, in this article there are several objectives; (1) becoming one of the references for writers and translators in understanding the importance of the translation process to find out the meaning of writing textbooks, (2) helping students and students learn to understand science through printed books. In particular, the discussion in this article is focused on understanding, strategies and the urgency of meaning in Arabic translation which is applied to writing lesson texts. This article uses a qualitative descriptive method. The data obtained are sourced from observations, findings, and literature reviews from various sources. The results of the analysis of this article are in the form of emphasizing the importance of the translation process as language transfer and messages from the source text which includes the source language into the target text which includes the target language. The translation process must refer to the understanding of both languages, and involve the sensitivity and feelings of the translator. This translation strengthens the position of language and cultural differences that are no longer a barrier in the development of science. Thus, by using a good and correct translation process, the meaning of textbooks can be fully grasped</span></span></pre>
FLIPPED CLASSROOM IN INDONESIAN ONLINE LEARNING: STUDENTS PRESPECTIVE
Authors: Suwartini Yati , Chaeruman Uwes Anis , Lustiyantie Ninuk 
Published: December 2021

Abstract
The Flipped Classroom is a teaching method that makes use of technology to provide a self-directed learning environment for students. The purpose of this article is to learn about high school students' perspectives on Flipped Classroom, the use of video and social media, time spent studying, mastery of learning materials, and completion of online learning. This study is a descriptive study. Questionnaires were presented to 95 Indonesian students who were chosen at random. In general, when students use Flipped Classroom in Indonesian lessons, they spend less time doing assignments or homework, they enjoy learning more, and they benefit from learning videos in Flipped Classroom to help them grasp the material. This article demonstrates how Flipped Classroom improves student participation, communication, and understanding.

Keywords: Flipped Classroom, online learning, technology
Emergency Department Stress Radiographs of Lateral Compression Type-1 Pelvic Ring Injuries Are Safe, Effective, and Reliable
Authors: DeKeyser Graham J. , Kellam Patrick J. , Haller Justin M. , Higgins Thomas F. , Marchand Lucas S. , Rothberg David L. 
Published: December 2021

Background:
Occult instability of lateral compression type-1 (LC1) pelvic ring injuries may be determined with a fluoroscopic stress examination under anesthesia (EUA) performed in the operating room. We hypothesized that LC1 injuries, similar to some fractures of the extremities, could be radiographically stressed for stability in the emergency department (ED). Our primary objective was to determine if stress examination of LC1 fractures could be safely and accurately performed in the ED and could be tolerated by patients.

Methods:
A prospective, consecutive series of 70 patients with minimally displaced LC1 pelvic injuries (<10-mm displacement on presentation) underwent stress examinations performed by the on-call orthopaedic resident in the ED radiology suite. The stress examination series included static 40° inlet, internal rotation stress inlet, and external rotation stress inlet views. Pelvic fractures that had positive stress results (≥10 mm of overlap of the rami) were indicated for a surgical procedure. These fractures also underwent EUA in order for the 2 techniques to be compared.

Results:
All patients tolerated the ED stress examination without general anesthetic or hemodynamic instability. Fifty-seven patients (81%) had negative stress results and were allowed to bear weight. All patients with negative stress results who had 3-month follow-up went on to radiographic union without substantial displacement. For the patients with a positive stress result in the ED, the mean displacement was 15.15 mm (95% confidence interval [CI], 10.8 to 19.4 mm) for the ED stress test and 15.60 mm (95% CI, 11.7 to 19.4 mm) for the EUA (p = 0.86). Two patients with a negative ED stress test did not mobilize during their hospitalization and underwent EUA and conversion to a surgical procedure. Thus, a total of 11 patients underwent both stress testing in the ED and EUA; no patient had a positive result on one test but a negative result on the other.

Conclusions:
ED stress examination of LC1 injuries is a safe and reliable method to determine pelvic ring stability. The displacement measured in the ED stress examination is similar to the displacement measured under general anesthesia. Furthermore, a negative ED stress examination predicts successful nonoperative treatment. Given the results of this study, we encourage the use of stress examination in the ED for LC1-type injuries involving complete sacral fractures only. Widescale adoption of this streamlined protocol may substantially diminish cost, anesthetic risk, and potential operations for patients.

Level of Evidence:
Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.
One-Way Self-Expanding Rod in Neuromuscular Scoliosis
Authors: Gaume M. , Hajj R. , Khouri N. , Johnson M.B. , Miladi L. 
Published: December 2021

Background:
Fusionless techniques for the treatment of neuromuscular early-onset scoliosis (EOS) are increasingly used to preserve spinal and thoracic growth and to postpone posterior spinal fusion (PSF). These techniques have greatly improved thanks to magnetically controlled growing rods, which allow the avoidance of repeated surgery. However, the surgery-related complication rate remains high. The objective of the current study was to report the preliminary outcomes of 21 patients with neuromuscular EOS who were treated with a 1-way self-expanding rod (OWSER). This device was designed to avoid repeated surgery and preserve spinal and thoracic growth thanks to its free rod sliding.

Methods:
Patients with neuromuscular EOS who underwent OWSER fixation were prospectively reviewed; follow-up was a minimum of 3 years. The instrumentation relies on a bipolar construct from T1 to the sacrum, with proximal fixation by double thoracic hook-claws and distal fixation by iliosacral screws. The device comprises a rod with a notched part sliding in 1 direction inside a domino. Changes in Cobb angle, pelvic obliquity, thoracic kyphosis, lumbar lordosis, T1-S1 and T1-T12 length, space available for the lung, and chest width were assessed. Complications were reviewed.

Results:
The mean age at surgery was 10.5 years. The mean follow-up was 3.9 years. The mean pelvic obliquity improved from 20° preoperatively to 8° postoperatively and to 6° at the latest follow-up. The mean Cobb angle improved from 66° preoperatively to 38° postoperatively and to 32° at the latest follow-up. The mean preoperative kyphosis was reduced from 41° to 26° at the latest follow-up (p = 0.14). The mean lordosis was 34° preoperatively and 38° at the latest follow-up. The mean growth per month was 0.8 mm for the T1-T12 segment and 1.5 mm for T1-S1. The global complication rate was 38% (2 surgical site infections, 3 cases of lack of rod expansion, 1 case of pyelonephritis, and 2 central venous catheter-related infections). No PSF had been performed at the latest follow-up.

Conclusions:
Use of the OWSER with a minimally invasive bipolar technique for neuromuscular EOS provided satisfactory correction of spinal and pelvic deformities at 3 years of follow-up. A longer follow-up is required.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Análisis de la inclusión de contenidos TIC contextualizados en Escuelas Taller dirigidas a la formación laboral de adultos
Authors: Rial Costa Manuel , Sánchez Oropeza Gregorio 
Published: December 2021

En los años ochenta, del pasado siglo, se puso en marcha una concepción educativa dual en España, las Escuelas Taller. Esta se dirigió a un público con unos requisitos especiales: parados de larga duración con problemas de inclusión laboral en sus respectivas especialidades, unido a su carencia educativa.
Veinte años después de haberlas puesto en marcha, se incorporó al currículo de las mismas el módulo de Alfabetización Digital, cuyo fin era acercar al alumnado a las TIC y a su aplicación en la familia profesional sobre la que se desempeñó la acción formativa.
Este estudio, analiza los contenidos recogidos en el currículo del módulo de Alfabetización Digital de la Escuela Taller de Cambados-Pontevedra (ESPAÑA) “Caminos Jacobeos” y ”Cambados Medioambiental”, su contextualizados a la formación del alumnado al que va dirigido, el cual ha sufrido, en los últimos años, una serie de crisis económicas que han provocado la aparición de brechas socioeconómicas.
Los resultados, reflejan las inquietudes del alumnado en materia TIC, la adquisición de habilidades y competencias contextualizadas en su formación, y las exigencias de nuevos módulos de formación requeridos y no contemplados en su currículo, pero que la sociedad en la que van a dirigir sus actuaciones les demandan.