bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obesity and Severity COVID-19 : Literature Review Study
Authors: Muharramah Disa Hijratul , Prihartono Nurhayati 
Published: September 2021

Background: Coronavirus disease (COVID-19) caused by SARS-CoV 2 (Severe Acute Respiratory Syndrome) has spread worldwide and infected more than 180 million confirmed cases and 3,9 million deaths. The clinical manifestations of COVID-19 range from asymptomatic or mild infection to severe. Previous reports identified that obesity is associated with the condition of a person infected with COVID-19 develop into severe. This study aims at examining the risk of severity COVID-19 associated with obesity Methods: This study was conducted a literature review method. There are ten articles obtained from online databases at Pubmed, Google Schoolar and the Wiley Online Library.Result: The results of various studies using cohort and cross-sectional study designs show that obesity has a statistically significant association with increasing risk for the severity of COVID-19. Obese individuals infected with COVID-19 suffer severe and critical symptoms that impact patients admitted to ICU, intubation and death.Conclusion : Obesity increase the risk for severity of COVID-19. Maintain healthy life style, including routine exercise, choice of healthy food and routine medical checkup may reduce the risk of severity of COVID-19
Hubungan Tingkat Pengetahuan dan Tingkat Kepatuhan Minum Obat dengan Tingkat Kekambuhan Lupus Eritematosus Sistemik
Authors: Rahayu Dinda Sinta , Udiyono Ari , Saraswati Lintang Dian 
Published: September 2021

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with varied manifestations and characterized by recurring flares. Lack of disease knowledge and non-compliance with drug therapy are an important cause of not achieving treatment targets and worsening lupus symptoms.Methods: This research is a descriptive study with a cross-sectional approach. The research method is quantitative. The sample in this study were 136 patients who came to examine themselves at Central-General Hospital in Semarang City. The sampling technique used in this study was total sampling. This study used a questionnaire to determine the variables studied.Result: The results of this study indicate a significant correlation between the level of knowledge (r=-0,332; p < 0,05) and level of drug adherence (r=-0,644; p < 0,05) to the level of systemic lupus erythematosus flaresConclusion : Based on the results, there is a correlation between knowledge and drug adherence to the level of systemic lupus erythematosus flares. The recommendation given is an integrated approach between patients and health care providers to improve patients understanding of systemic lupus erythematosus flares. Beside of that, specific attention should be paid to integrate the service provision system into the collaborative approach of the patients and his/her family in order to promote the level of drug adherence.
The “Jew,” the Nation and Assimilation: The Old Testament and the Fashioning of the “Other” in German and Dutch Protestant Thought
Authors: van der Tol Mariëtta 
Published: September 2021

AbstractThis article discusses a reorientation of supersessionist postures in German and Dutch Protestant reflection on emerging nation states in the nineteenth-century. Historically, Christian thought often othered “the Jew” as the “nascent Christian.” Since the seventeenth-century, Protestant theologians also entertained the possibility of theological othering on the basis of the legalism of the Mosaic covenant, of which ancient biblical Israel and its cultural liturgies were regarded as a token. In the context of the modern nation, German and Dutch Protestant thought entertained this typological othering of biblical nationhood to construct the modern Jew as “Gentile” to the modern nation. As “Gentile,” “the Jew” remains the embodiment of the ultimate other, yet as “nascent Christian,” modern Jews begin to face an unrelenting demand to assimilate. This conundrum contributed to a fundamental tension in the imaginary of the nation, namely between patterns of othering and structures of belonging, echoing far beyond antisemitism, and especially in patterns of othering that are inherent to racism and Islamophobia.
Effect of moderate intensity resistance training with blood flow restriction on muscle strength and girth in young adults – a randomized control trial
Authors: Gujral Tanya , Subburaj Jeyanthi , Sharma Kiran 
Published: September 2021

Abstract

Objectives
To examine the effects of moderate intensity resistance training with blood flow restriction on muscle strength and forearm girth.

Methods
Total of 39 students enrolled in this study were divided into three groups that is group A (control group), group B and group C. Group A performed exercise training without restrictive pressure, group B and C performed exercise training with 50 and 75 mmHg respectively. Both the outcome measures were evaluated on day 1 and day 12th with the help of digital dynamometer and measuring tape.

Results
Repeated measure ANOVA with Post hoc analysis was done using SPSS software version 20. The result of the study showed significant (p≤0.05) within subject improvement in muscle strength and muscle girth in all the three groups. However, significant improvement in muscle strength was found in between group analysis (p≤0.05).

Conclusions
The results of the study can be concluded as the partial blood flow restriction (50 mmHg) with moderate intensity resistance training resulted in greater handgrip strength than the other two groups. No difference was found in forearm girth among the three groups, however within the group difference was found.
Universal and macro-areal patterns in the lexicon
Authors: Georgakopoulos Thanasis , Grossman Eitan , Nikolaev Dmitry , Polis Stéphane 
Published: September 2021

AbstractThis paper investigates universal and areal structures in the lexicon as manifested by colexification patterns in the semantic domains of perception and cognition, based on data from both small and large datasets. Using several methods, including weighted semantic maps, formal concept lattices, correlation analysis, and dimensionality reduction, we identify colexification patterns in the domains in question and evaluate the extent to which these patterns are specific to particular areas. This paper contributes to the methodology of investigating areal patterns in the lexicon, and identifies a number of cross-linguistic regularities and of area-specific properties in the structuring of lexicons.
Fractional Hermite-Hadamard-type inequalities for interval-valued co-ordinated convex functions
Authors: Budak Huseyin , Kara Hasan , Ali Muhammad Aamir , Khan Sundas , Chu Yuming 
Published: September 2021

Abstract
In this work, we introduce the notions about the Riemann-Liouville fractional integrals for interval-valued functions on co-ordinates. We also establish Hermite-Hadamard and some related inequalities for co-ordinated convex interval-valued functions by applying the newly defined fractional integrals. The results of the present paper are the extension of several previously published results.
Photonic crystal nanobeam cavities with lateral fins
Authors: Liu Zhonghe , Chen Yudong , Ge Xiaochen , Zhou Weidong 
Published: September 2021

Abstract
We present the design, fabrication, and characterization of suspended arrays of small volume, high quality factor (Q) silicon nitride photonic crystal nanobeam (PCNB) cavities with lateral nanorod fin structures. By controlling the alignment position of the fins with respect to the air holes, the resonance wavelength and Q-factor of the PCNB cavities can be tuned to realize the desired performance. Measured tunable range of 2 × 104 and 10 nm is achieved for Q-factor and resonance wavelength, respectively, with the highest Q-factor measured at 2.5 × 104. Incorporating such nanorod fins into the nanobeam cavity is demonstrated to provide improved mechanical support, thermal transport, and channels of lateral carrier injection for the suspended PCNB. The proposed PCNB cavities with lateral fins are advantageous for energy efficient, ultra-compact lasers, modulators, filters, and sensors.
Azimuthally and radially polarized orbital angular momentum modes in valley topological photonic crystal fiber
Authors: Zhang Zhishen , Lu Jiuyang , Liu Tao , Gan Jiulin , Heng Xiaobo , Wu Minbo , Li Feng , Yang Zhongmin 
Published: September 2021

Abstract
Artificially tailoring the polarization and phase of light offers new applications in optical communication, optical tweezers, and laser processing. Valley topological physics provides a novel paradigm for controlling electromagnetic waves and encoding information. The proposed fiber has the inner and outer claddings possessing opposite valley topological phases but the same refractive indices, which breaks through the polarization constraints of the traditional fiber. Robust valley edge states exist at the domain walls between the inner and outer claddings because of bulk edge correspondence. The valley topological fiber modes exhibit the unprecedented radial and azimuthal polarization with high-order azimuthal index. Those topological modes are robust against the disorder of the fiber structure. These results enable guide and manipulate the optical polarization and angular momentum in fiber with high fidelity. The proposed fiber has the potential to become a powerful optical spanner for the application of bio-photonics.
Crystal structure of bis(4-bromo-2-(((3-bromopropyl)imino)methyl)phenolato-κ2N,O)-oxido-vanadium(IV), C20H20Br4N2O3V
Authors: Wei Wei , Xia Juan , Zhang Wei-Ya , Zhang Heng-Qiang , Fang Fu-Jian , Xin Yang , Zheng Xiu-Jun 
Published: September 2021

Abstract
C20H20Br4N2O3V, monoclinic, P21/c (no. 14), a = 12.6011(10) Å, b = 16.5997(8) Å, c = 12.9206(12) Å, β = 119.006(11)°, V = 2363.7(4) Å3, Z = 4, R
gt
(F) = 0.0518, wR

ref
(F
2) = 0.1062, T = 153(2) K.
Philosophy of Scientific Malpractice
Authors: Andersen Hanne 
Published: September 2021

AbstractThis paper presents current work in philosophy of science in practice that focusses on practices that are detrimental to the production of scientific knowledge. The paper argues that philosophy of scientific malpractice both provides an epistemological complement to research ethics in understanding scientific misconduct and questionable research practices, and provides a new approach to how training in responsible conduct of research can be implemented.
Kinetics of methylene blue dye adsorptive removal using halloysite nanocomposite hydrogels
Authors: Ata Sadia , Amin Sadaf , Bibi Ismat , Mohsin Ijaz-ul- , Islam Atif , Mehmood Azra , Irshad Saba , Al-Fawzan Foziah F. , Alissa Siham A. , Iqbal Munawar 
Published: September 2021

Abstract
In the present work, halloysite nano-clay (HNTs) based hydrogel was fabricated and their efficiency for the removal of methylene blue dye was studied. The hydrogel films were prepared with varying amount of halloysite nano-clay via facile solution casting method. Effect of halloysite clay on adsorption performance of composite was investigated. The hydrophobic thermoplastic synthetic polymer, polylactic acid (PLA) was blended with hydrophilic polymer polyvinyl alcohol (PVA) and HNTs to synthesize hydrogels. Swelling behavior and antimicrobial efficiency was also evaluated. The halloysite incorporating films showed excellent antibacterial activity. Swelling capacity of hydrogel with increased halloysite content was reduced due to increased crosslinking among polymer chains. Halloysite incorporated hydrogel exhibited higher adsorption ability as compared to film comprising of only PVA and PLA and dye removal followed pseudo first order kinetics. Film with 0.03 g HNTs rapidly attained adsorption-desorption equilibria and removed the dye completely within 30 min. Results confirmed that synthesized film could be potentially used for the removal of cationic dye and fabricated hydrogel film have promising potential for wastewater treatment since a higher adsorption capacity was observed for halloysite nano-clay incorporated hydrogel.
Oscillatory Correlates of Intentional Forgetting: The Role of Theta and Alpha Power in Item-Method Directed Forgetting
Authors: Scholz Sebastian , Dutke Stephan , Busch Niko A. 
Published: September 2021

AbstractResults from item-method directed forgetting suggest that individuals are able to intentionally forget processed information. Most research suggests that either selective rehearsal of to-be-remembered or inhibitory control of to-be-forgotten information is accountable for the effects of intentional forgetting. Some research, however, hypothesized that the time to process information mediates the underlying mechanism. To test this hypothesis, the current study investigated associations between oscillatory power in theta (3–7.5 Hz) and alpha frequencies (8–13 Hz) and intentional forgetting in human participants and explored whether or not these mechanisms depended on processing time. Previously, theta power was shown to be associated with the creation of episodic memory traces and alpha power with inhibition. We therefore expected to find associations between these neural signatures and behavioral effects. Consistent with our hypotheses, we revealed increased theta power for to-be-remembered and increased alpha power for to-be-forgotten information and that the effects of activity in both frequency bands were influenced by the time individuals were given for processing the memory cue. These results suggest that not one but two mechanisms, rehearsal and inhibitory control, are accountable for item-method directed forgetting, both with different temporal profiles.
Adrenal insufficiency in immunochemotherapy for small-cell lung cancer with ectopic ACTH syndrome
Authors: Nakajima Hiroki , Niida Yasuhiro , Hamada Eriko , Hirohito Kuwata , Ota Masahide , Okada Sadanori , Mohri Takako , Kurematsu Yukako , Hontsu Shigeto , Muro Shigeo , Takahashi Yutaka 
Published: September 2021

Summary
Ectopic ACTH (adrenocorticotrophic hormone) syndrome (EAS) is rarely associated with small-cell lung cancer (SCLC). Although chemotherapy is initially effective for SCLC, complicated EAS scarcely improves. Recently, immune checkpoint inhibitors have been used to treat SCLC. Atezolizumab plus chemotherapy for SCLC improved progression-free survival compared to conventional chemotherapy. However, little has been reported on the efficacy of the combination therapy for SCLC with EAS. We report a 72-year-old male who presented with 4-week history of leg oedema, proximal myopathy, weight loss, and worsened symptoms of diabetes and hypertension. Laboratory findings revealed hypokalaemia, increased plasma ACTH, and serum cortisol levels. Cortisol levels were not suppressed by the high-dose dexamethasone test. Chest and abdominal CT revealed a right lower lobe tumour with multiple metastases on the hilar lymph nodes, liver, lumbar spine, and bilateral enlarged adrenal glands. The patient was diagnosed with stage 4B SCLC with EAS. Hypercortisolaemia was then treated with metyrapone and atezolizumab plus chemotherapy, which was started for SCLC. After 10 days, the tumour shrank noticeably, and the ACTH level drastically decreased concomitantly with low cortisol levels with symptoms of fever, appetite loss, and general fatigue. Hydrocortisone treatment was initiated, and the symptoms resolved immediately. We describe a case of SCLC with EAS treated with atezolizumab plus chemotherapy, presenting with adrenal insufficiency. Close observation is required for patients with adrenal insufficiency receiving atezolizumab plus chemotherapy because of its stronger effect. Furthermore, advances in cancer therapy and care for endocrine paraneoplastic syndrome needs to be adapted.

Learning points

The immune checkpoint inhibitor atezolizumab has recently been approved for the treatment of small-cell lung cancer (SCLC).

Approximately 1–6% of tumour ectopically produce ACTH and cause ectopic ACTH syndrome (EAS) as an endocrine paraneoplastic syndrome.

The use of combined chemotherapy and atezolizumab in the ectopic ACTH syndrome secondary to small-cell lung cancer may cause a precipitous fall in circulating ACTH/cortisol, resulting in symptomatic adrenal insufficiency

The advances in cancer therapy and treatment for endocrine paraneoplastic syndrome need to be adapted.
Synthesis and characterization of graphene oxide flakes for transparent thin films
Authors: Abaszade R.G. , Mamedova S.A. , Agayev F.G. , Budzulyak S.I. , Kapush O.A. , Mamedova M.A. , Nabiyev A.M. , Kotsyubynsky V.O. 
Published: September 2021

We have synthesized large scale, thin, transparent graphene oxide (GO) flakes by Hummer’s method and investigated their suitability for fabrication of transparent nanocomposites. The GO flakes were comprehensively characterized by X-ray diffraction, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX), Raman spectroscopy and Differential Scanning Calorimetry (DSC). X-ray diffraction displayed the peak of graphene oxide at 9°degree, which is characteristic peak of GO in agreement with the literature results. Scanning Electron Microscopy images revealed that thin, transparent, flake form GO with 14,8 µm lateral size and 0,31µm thickness were synthesized. The comparison with literature results show that for the first time, our group could synthesize large scale, thin and more transparent GO flakes by simple Hummer’s method using simple dispersed graphite. EDX measurements indicate the formation of layered structure with oxygen containing functional groups. The intensity ratio between D and G peaks in the Raman spectra proves that less defective GO flakes have been synthesized. The solution ability of the synthesized material indicate that high quality GO flakes were synthesized, which make them effective soluble material due to oxygen containing groups formed on the graphene plane during synthesis process.DSC results shows that these flakes are thermally stable till 200°C. Due to high solubility properties, large scale and transparency they can be very useful in fabrication of high optical transparent nanocompoties for replacement indium tin oxide transparent conductors in solar panels, biomedical applications and microwave absorbers for electromagnetic interference (EMI) environmental protection.
A randomized comparative study of platelet-rich fibrin along with hydroxyapatite graft for the treatment of 3-walled defects in chronic periodontitis
Authors: Thetay Anshuj Ajayrao , Kumar Santosh , Irfan Mohammed , Lund Rafael Guerra , Desai Khushboo , Hirani Tanvi , Sevak Jeel 
Published: September 2021

Background. Platelet Rich Fibrin (PRF) is a concentrate of leucocyte and platelets that contains various polypeptide growth factors. It has immense potential for use as a periodontal regenerative material in periodontal defects. Porous hydroxyapatite (HA) has long been used as bone grafting material. Recently it has been reported that when PRF is used in combination with HA, itgives a synergistic effect and results in a better periodontal regeneration. The present study aims to explore the clinical and radiographic effectiveness of autologous PRF versus PRF+HA in the regenerative treatment of intrabony defects (IBD) in patients with chronic periodontitis.
Methods. Sixty patients with IBDs were divided into test and control groups. The test group patients were treated with autologous PRF, whereas the control group patients were treated with PRF+HA. Clinical parameters were recorded at baseline, three months, six months and nine months’ time interval. Radiographic measurements were recorded at baseline and nine months.
Results. A reduction in PI, MGI, PPD, RAL, and IBD was observed in both the groups at nine months. Mean IBD reduction in the control group was 3.70 ± 1.16 mm, whereas, the mean reduction in the test group was 4.80 ± 1.03 mm, showing a significant reduction in IBDs. Similarly, the percentage of bone fill in the test group was 65% ± 3.67%, whereas bone fill in controls was 56.7% ± 3.56%, showing a significant bone fill in the study group.
Conclusion. Treatment of IBDs with PRF+HA showed a significant improvement in all the clinical and radiographic parameters. When HA was added to PRF, it increased the regenerative effect in the treatment of 3 wall IBDs.
A survey on dental students’ perception regarding online learning during COVID-19 pandemic
Authors: Kui Andreea , Jiglau Anca Labunet , Chisnoiu Andrea , Negucioiu Marius , Balhuc Silvia , Constantiniuc Mariana , Buduru Smaranda 
Published: September 2021

Background and aims. This study aimed to assess the students’ opinion about the efficiency of online teaching and also about the methods and features to be implemented even after this pandemic period would pass.
Methods. A questionnaire was formulated in order to evaluate the students’ perception about the teaching methods used by the Faculty of Dentistry, which was distributed through email.
Results. The answers of 208 students were analyzed. There were 157 women and 51 men, 119 were from Cluj County, while 89 were from other Romanian counties; 102 of the students were in the 4th year of study, while 62 were still in the preclinical years (1st, 2nd, 3rd), and the rest of 44 of the subjects, were in the 5th or 6th year of study. 85.8% of the respondents were satisfied with the traditional lectures, 51.7% considered that online lectures were more useful than the traditional. 187 (88.6%) of the students were satisfied with the traditional practical activities, while 37 (16.1%) believed that online activities were more useful to them, 111 (52.6%), believed that they were able to communicate better with the teacher during the online lectures.
Conclusions. Overall positive responses were reported regarding the acceptability and usability of online learning. The students viewed online learning helpful as a supplement to their learning rather than a replacement for traditional teaching methods.
Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
Authors: Wang Di , Li Yan , Zhai Qian-qian , Zhu Yun-feng , Liu Bei-yan , Xu Yun 
Published: September 2021

Testicular damage and testosterone secretion disorder are associated with diabetes mellitus. Quercetin, a common flavonoid, has antioxidant, anti-cancer, and blood sugar lowering effects. Therefore, this study aims to investigate the effect of quercetin on the reproductive system of male rats with diabetes in vivo and in vitro and elucidate its mechanism. Streptozotocin (STZ) induction was used to establish a diabetes model in forty male Sprague Dawley (SD) rats, which were subsequently administered with 20 or 50 mg/kg of quercetin. Leydig cells of rat testes were treated by high glucose (HG) followed by 5 or 10 μM quercetin. Two doses of quercetin increased rat body weight and testicular weight, decreased blood glucose,and inhibited oxidative stress. RT-qPCR and Western blotting revealed that quercetin alleviated STZ-induced testicular damage and promoted testosterone synthesis. Both doses of quercetin reduced ROS and MDA levels, and increased SOD level in HG-treated cells. Both, in vivo and in vitro results confirmed that a high dose of quercetin was more effective. MiR-1306-5p was upregulated in testicular tissue of diabetic rats and HG-treated cells. 17β-hydroxysteroid dehydrogenase (HSD17B7) was a target of miR-1306-5p and HSD17B7 was downregulated in STZ-induced rat tissues and HG-treated cells. HSD17B7 overexpression reversed the increase of C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (Grp78) protein levels as well as eIF2α phosphorylation level and promotion of cell apoptosis caused by miR-1306-5p overexpression. Moreover, overexpression of HSD17B7 activated the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) axis in HG-treated cells. In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR-1306-5p/HSD17B7 axis in diabetic rats.