bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for recurrent gastroesophageal reflux disease after Thal fundoplication
Authors: Ishii Daisuke , Miyagi Hisayuki , Hirasawa Masatoshi 
Published: August 2021

Abstract
Purpose
The recurrence rate of gastroesophageal reflux disease (GERD) after fundoplication has been reported to be 7–25%. We investigated the risk factors for recurrence of GERD after Thal fundoplication (TF) in our department with the aim of further reducing the recurrence rate of GERD.

Methods
We retrospectively analyzed 276 patients who underwent TF for GERD at our hospital between 2000 and 2019. Retrospectively considered variables were obtained from the medical records of patients. The variables included patient characteristics, GERD severity, surgery-related factors and postoperative course.

Results
The postoperative GERD recurrence rate was 5.8%. In the univariate analysis, the presence of convulsive seizures (12/4 vs. 110/150, p = 0.046) and the absence of a tracheostomy (0/16 vs. 53/207, p = 0.048) at the time of TF were significantly associated with recurrence. In the multivariate analysis, the presence of convulsive seizures at the time of TF was the only factor significantly associated with recurrence.

Conclusion
The presence of convulsive seizures and the absence of a tracheostomy at the time of TF were significantly associated with GERD recurrence after TF. Active control of seizures and consideration of surgical indications, including assessment of respiratory status, are important in preventing the recurrence of GERD after TF.
Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors
Authors: van de Wouw Jens , Sorop Oana , van Drie Ruben W. A. , Joles Jaap A. , Danser A. H. Jan , Verhaar Marianne C. , Merkus Daphne , Duncker Dirk J. 
Published: August 2021

AbstractIn the present study, we tested the hypothesis that multiple risk factors, including diabetes mellitus (DM), dyslipidaemia and chronic kidney disease (CKD) result in a loss of nitric oxide (NO) signalling, thereby contributing to coronary microvascular dysfunction. Risk factors were induced in 12 female swine by intravenous streptozotocin injections (DM), a high fat diet (HFD) and renal artery embolization (CKD). Female healthy swine (n = 13) on normal diet served as controls (Normal). After 5 months, swine were chronically instrumented and studied at rest and during exercise. DM + HFD + CKD swine demonstrated significant hyperglycaemia, dyslipidaemia and impaired kidney function compared to Normal swine. These risk factors were accompanied by coronary microvascular endothelial dysfunction both in vivo and in isolated small arteries, due to a reduced NO bioavailability, associated with perturbations in myocardial oxygen balance at rest and during exercise. NO synthase inhibition caused coronary microvascular constriction in exercising Normal swine, but had no effect in DM + HFD + CKD animals, while inhibition of phosphodiesterase 5 produced similar vasodilator responses in both groups, indicating that loss of NO bioavailability was principally responsible for the observed coronary microvascular dysfunction. This was associated with an increase in myocardial 8-isoprostane levels and a decrease in antioxidant capacity, while antioxidants restored the vasodilation to bradykinin in isolated coronary small arteries, suggesting that oxidative stress was principally responsible for the reduced NO bioavailability. In conclusion, five months of combined exposure to DM + HFD + CKD produces coronary endothelial dysfunction due to impaired NO bioavailability, resulting in impaired myocardial perfusion at rest and during exercise.
Exploring STR sequencing for forensic DNA intelligence databasing using the Austrian National DNA Database as an example
Authors: Hölzl-Müller Petra , Bodner Martin , Berger Burkhard , Parson Walther 
Published: August 2021

AbstractHere, we present the results from a population study that evaluated the performance of massively parallel sequencing (MPS) of short tandem repeats (STRs) with a particular focus on DNA intelligence databasing purposes. To meet this objective, 247 randomly selected reference samples, earlier being processed with conventional capillary electrophoretic (CE) STR sizing from the Austrian National DNA Database, were reanalyzed with the PowerSeq 46Y kit (Promega). This sample set provides MPS-based population data valid for the Austrian population to increase the body of sequence-based STR variation. The study addressed forensically relevant parameters, such as concordance and backward compatibility to extant amplicon-based genotypes, sequence-based stutter ratios, and relative marker performance. Of the 22 autosomal STR loci included in the PowerSeq 46GY panel, 99.98% of the allele calls were concordant between MPS and CE. Moreover, 25 new sequence variants from 15 markers were found in the Austrian dataset that are yet undescribed in the STRSeq online catalogue and were submitted for inclusion. Despite the high degree of concordance between MPS and CE derived genotypes, our results demonstrate the need for a harmonized allele nomenclature system that is equally applicable to both technologies, but at the same time can take advantage of the increased information content of MPS. This appears to be particularly important with regard to database applications in order to prevent false exclusions due to varying allele naming based on different analysis platforms and ensures backward compatibility.
Global evidence of constraints and limits to human adaptation
Authors: Thomas Adelle , Theokritoff Emily , Lesnikowski Alexandra , Reckien Diana , Jagannathan Kripa , Cremades Roger , Campbell Donovan , Joe Elphin Tom , Sitati Asha , Singh Chandni , Segnon Alcade C. , Pentz Brian , Musah-Surugu Justice Issah , Mullin Cristina A. , Mach Katharine J. , Gichuki Leah , Galappaththi Eranga , Chalastani Vasiliki I. , Ajibade Idowu , Ruiz-Diaz Raquel , Grady Caitlin , Garschagen Matthias , Ford James , Bowen Kathryn ,   Global Adaptation Mapping Initiative Team
Published: August 2021

AbstractConstraints and limits to adaptation are critical to understanding the extent to which human and natural systems can successfully adapt to climate change. We conduct a systematic review of 1,682 academic studies on human adaptation responses to identify patterns in constraints and limits to adaptation for different regions, sectors, hazards, adaptation response types, and actors. Using definitions of constraints and limits provided by the Intergovernmental Panel on Climate Change (IPCC), we find that most literature identifies constraints to adaptation but that there is limited literature focused on limits to adaptation. Central and South America and Small Islands generally report greater constraints and both hard and soft limits to adaptation. Technological, infrastructural, and ecosystem-based adaptation suggest more evidence of constraints and hard limits than other types of responses. Individuals and households face economic and socio-cultural constraints which also inhibit behavioral adaptation responses and may lead to limits. Finance, governance, institutional, and policy constraints are most prevalent globally. These findings provide early signposts for boundaries of human adaptation and are of high relevance for guiding proactive adaptation financing and governance from local to global scales.
In silico and gene expression analysis of the acute inflammatory response of gilthead seabream (Sparus aurata) after subcutaneous administration of carrageenin
Authors: Campos-Sánchez Jose Carlos , Mayor-Lafuente Javier , Guardiola Francisco A. , Esteban María Ángeles 
Published: August 2021

AbstractInflammation is one of the main causes of loss of homeostasis at both the systemic and molecular levels. The aim of this study was to investigate in silico the conservation of inflammation-related proteins in the gilthead seabream (Sparus aurata L.). Open reading frames of the selected genes were used as input in the STRING database for protein–protein interaction network analysis, comparing them with other teleost protein sequences. Proteins of the large yellow croaker (Larimichthys crocea L.) presented the highest percentages of identity with the gilthead seabream protein sequence. The gene expression profile of these proteins was then studied in gilthead seabream specimens subcutaneously injected with carrageenin (1%) or phosphate-buffered saline (control) by analyzing skin samples from the injected zone 12 and 24 h after injection. Gene expression analysis indicated that the mechanisms necessary to terminate the inflammatory response to carrageenin and recover skin homeostasis were activated between 12 and 24 h after injection (at the tested dose). The gene analysis performed in this study could contribute to the identification of the main mechanisms of acute inflammatory response and validate the use of carrageenin as an inflammation model to elucidate these mechanisms in fish.
A Comparison of MMPI-2 Profiles Between Parental Alienation Cases and Custody Cases
Authors: Roma Paolo , Marchetti Daniela , Mazza Cristina , Ricci Eleonora , Fontanesi Lilybeth , Verrocchio Maria Cristina 
Published: August 2021

AbstractThe present study aimed at understanding the personality features of mothers and fathers engaged in parental alienation—a family dynamic in which one parent behaves in a way that foments a child’s unfounded emotional rejection of the other parent. The process is considered a complex form of child psychological maltreatment, with significant negative consequences. In cases of conflictual separation and divorce, parental alienation can be difficult—yet important—to identify. In this context, use of psychological assessment to understand parents’ personality characteristics may facilitate the early identification of parental alienation and related abuses. A comparative analysis of the Minnesota Multiphasic Personality Inventory-2 profiles of 41 couples engaged in parental alienation and 39 control couples (i.e., not involved in parental alienation) was used to assess the personality characteristics of mothers and fathers engaged in parental alienation. The results indicated that mothers who were classified as alienating presented a faking-good defensive profile, denied hostile and negative impulses, blamed others for their problems, and displayed excessive sensitivity. On the other side, fathers who were classified as targets of alienating behaviors were adapted to chronic depressive states, social isolation, and interpersonal conflict. The results suggest that the personality profile of parents involved in parental alienation may provide useful insight for custodial cases, prevent further abuse, and contribute to improving psychological and rehabilitative programs. Clinical and forensic implications are discussed.
Non-integrability of a model of elastic dumbbell satellite
Authors: Combot Thierry , Maciejewski Andrzej J. , Przybylska Maria 
Published: August 2021

AbstractWe study the integrability of a model of elastic satellite whose centre of mass moves in a circular Keplerian orbit around a gravity centre. The satellite is modelled by two point masses connected by an extensible massless spring that obeys Hooke’s law. It is assumed that the distance between point masses is much smaller than the radius of the orbit, so the orbital motion of the satellite is not perturbed by its rotational motion. The gravity potential of the satellite is expanded into a series with respect to its size up to quadratic terms which describe the gravity gradient torque acting on the satellite. Two cases are considered with Hooke’s centre localised in the centre of mass of the dumbbell and at an arbitrary point along a line connecting both masses. It is shown that the first case appears to be integrable and super-integrable for selected values of the parameter of the system. In the second case, model depends effectively only on one parameter and is non-integrable. In the proof, differential Galois integrability obstructions are used. For the considered sysem, these obstructions are deduced thanks to the recently developed symplectic Kovacic’s algorithm in dimension 4. According to our knowledge, this is the first application of this tool to a physical model.
Die Verantwortung des polizeilichen Einsatztrainings
Authors: Staller Mario S. , Körner Swen 
Published: August 2021

ZusammenfassungDas polizeiliche Einsatztraining hat eine große Bedeutung: Junge Polizist_innen werden dort im Rahmen ihrer Erstsozialisation ausgebildet, in der Praxis tätige Polizist_innen in einsatz- und konfliktrelevanten Bereichen geschult und weiterentwickelt. Neben diesen Inhalten werden innerhalb des Lehr-Lern-Settings explizit und implizit auch Werte, Einstellungen und Sichtweisen auf polizeiliche Einsatz- und Konfliktsituationen vermittelt. Der Beitrag zeigt die Verantwortung des polizeilichen Einsatztrainings auf, zu einer sozialen und gerechten Gesellschaft beizutragen. Am Beispiel (a) der vermittelten Gesellschaftsbilder und (b) der verwendeten Sprache skizzieren die Autoren für das polizeiliche Einsatztraining Anlässe und Potenziale, sich dieser Verantwortung reflektiert zu stellen.
Diversity of gobioid fishes in the late middle Miocene of northern Moldova, Eastern Paratethys – part I: an extinct clade of Lesueurigobius look-alikes
Authors: Reichenbacher Bettina , Bannikov Alexander F. 
Published: August 2021

AbstractStudies of otoliths suggest that Gobioidei, which are among the most species-rich groups of modern-day vertebrates, were prominent elements of late middle Miocene (early Sarmatian sensu lato) fish faunas in Europe and Western Asia. However, few complete skeletons have come to light. Here, we report an assemblage of six marine gobiid species, based on skeletons preserved with otoliths in situ, from the lower Volhynian (lower Sarmatian s.l.) of Karpov Yar, Naslavcea, northern Moldova (Eastern Paratethys). Previously only one of these species had been reported from the Central Paratethys, based on its otoliths alone. Five new species representing four new genera are described: †Katyagobius prikryli gen. et sp. nov., Pseudolesueurigobius manfredi gen. et sp. nov., †Sarmatigobius compactus gen. et sp. nov., †Yarigobius decoratus gen. et sp. nov., and †Y. naslavcensis gen. et sp. nov. All six species share the following set of characters, suggesting that they represent a monophyletic clade: 27–29 vertebrae (of which 10 are abdominal); spines of first dorsal fin distally filamentous; second dorsal fin with spine and 14–16 soft rays; anal fin with spine and 13–15 soft rays; caudal fin longish-to-lanceolate; otoliths (sagittae) with rounded, trapezoid-to-squarish shape. Their skeletal features suggest that they are closely related to Lesueurigobius Whitley, 1950, but the otoliths preserved in situ do not support such a classification. The new fossils most likely represent a stem lineage of the European Aphia lineage, and indicate that the diversity of gobiid lineages 12 million years ago differed clearly from that observed today.
Business Process Management Culture in Public Administration and Its Determinants
Authors: Kregel Ingo , Distel Bettina , Coners André 
Published: August 2021

AbstractPublic administration institutions increasingly use business process management (BPM) to innovate internal operations, increase process performance and improve their services. Research on private sector companies has shown that organizational culture may impact an organization's BPM and this culture is often referred to as BPM culture. However, similar research on public administration is yet missing. Thus, this article assesses BPM culture in Germany’s municipal administration. 733 online survey responses were gathered and analyzed using MANOVA and follow-up discriminant analyses to identify possible determinants of public administration’s BPM culture. The results indicate that the employees’ professional experience and their responsibility influence the assessment of BPM culture, as does the size of a municipality. Based on these findings, the article proposes testable relationships and an agenda for further research on BPM culture in public administration.
Histogram-based weighted median filtering used for noise reduction of digital elevation model data
Authors: Kilik Roland 
Published: August 2021

AbstractA new histogram-based robust filter developed for noise reduction of digital elevation model data is presented. When large percentage of data points in data matrices are contaminated with outlier noise, the noise reduction process can give better results than traditional median filtering, if elements with a potentially higher chance of being noise are eliminated by weighting from the input dataset before the median value is calculated. However, on the same matrices, there are likely to be subsets of data where unfiltered input is more reasonable for the calculation. The new method implementing weighting between these two cases is presented below, with its initial tuning and a comparison with both standard median filtering and the Most Frequent Value (MFV) method, as the latter being much more efficient than the usual methods. Following the description of the procedures, their effectiveness is compared for noise reduction in digital elevation model data systems, at various noise levels. The comparison is done mainly by three measures, with most of the focus on the $${L}_{1}$$

L
1

norm data distance results. Finally, a modified version of the method—which includes Steiner’s MFV filter as a core part—is also introduced, with similar examination. The method to be presented has been shown to be superior to conventional median filtering for most noise rates, and in many cases also to Steiner' MFV, for handling non-zero mean noises. The modified version of the method—with the help of Steiner's MFV—has also achieved this in handling zero mean noise, in the field of application described in the paper.
A Systematic Review of Interventions to Improve Healthcare Experiences and Access in Autism
Authors: Walsh Chloe , O’Connor Paul , Walsh Ellen , Lydon Sinéad 
Published: August 2021

AbstractAutistic individuals report barriers to accessing and receiving healthcare, and experience increased morbidity and mortality. This systematic review synthesizes 31 research studies evaluating interventions implemented to improve the healthcare experiences and/or access of autistic persons. Interventions were most commonly patient-focused (58.1%), focused on supporting the autistic individual to engage with, tolerate, or anticipate medical procedures, care, or settings. Fewer studies were provider-focused (48.4%) or organization-focused (6.5%). Interventions were typically evaluated using measures of reactions (45.2%) or behavior (48.4%), and outcomes were predominantly positive (80.6%). Further research is imperative and should look to how providers and organizations must change. Future research must be inclusive of the autistic community, must measure what matters, and must offer complete detail on interventions implemented.
Theoretical formulations and simulations of one-dimensional inhibition kinetics of ethanologenic microorganisms in batch fermenters
Authors: Bamaalabong Peter P. , Asiedu Nana Y. , Neba F. Abunde , Baidoo Francesca , Addo Ahmad 
Published: August 2021

Abstract
The utilization of bio-based technology for energy has piqued researchers' curiosity around the world. As a result, bioethanol fermentation has been a hot topic of research for many scientists since it uses less energy and chemicals, produces fewer harmful by-products and emissions, and has environmentally favorable applications. The modeling and simulations of one-dimensional product and substrate inhibitions for sorghum, maize, and cassava extracts are discussed in this paper. Because it provides an edge over other methodologies, mechanistic modeling techniques are used. Models of substrate and product inhibitions in one dimension (1-D) are constructed. These 1-D models are then confirmed using parameter estimates before being employed in the work's simulations. For each dynamic model constructed, model fitness coefficients (α) are calculated. For the product, the exponential inhibition model, sorghum extract data has the best model fitness coefficient (α = 0.4088), for product sudden stop inhibition model and cassava extract data gives the best model fitness coefficient ($$\alpha $$
α
= 0.4417) for product exponential model. The projected yield increases for substrate exponential inhibition with sorghum extract data, substrate linear inhibition with maize extract data, and substrate linear inhibition with cassava extract data are 74%, 27%, and 25%, respectively. This unique framework has offered the industry a wide choice of kinetics models to choose from to alleviate inhibitions in fermentation systems and maximize yield and productivity in the bioethanol fermentation process.

Article Highlights

The modeling of inhibitions namely linear, sudden stop, and exponential in batch fermentation processes are presented in this article.

Model fitness coefficient analysis showed the product as a primary inhibitor and substrate as a secondary inhibitor during the process

The cassava and maize processes described linear inhibition model and sorghum fermentation showed exponential product inhibition model.
Development of a Balanced Adaptive Time-Stepping Strategy Based on an Implicit JFNK-DG Compressible Flow Solver
Authors: Pan Yu , Yan Zhen-Guo , Peiró Joaquim , Sherwin Spencer J. 
Published: August 2021

AbstractA balanced adaptive time-stepping strategy is implemented in an implicit discontinuous Galerkin solver to guarantee the temporal accuracy of unsteady simulations. A proper relation between the spatial, temporal and iterative errors generated within one time step is constructed. With an estimate of temporal and spatial error using an embedded Runge-Kutta scheme and a higher order spatial discretization, an adaptive time-stepping strategy is proposed based on the idea that the time step should be the maximum without obviously influencing the total error of the discretization. The designed adaptive time-stepping strategy is then tested in various types of problems including isentropic vortex convection, steady-state flow past a flat plate, Taylor-Green vortex and turbulent flow over a circular cylinder at $${Re}=3\,900$$

Re

=
3

900

. The results indicate that the adaptive time-stepping strategy can maintain that the discretization error is dominated by the spatial error and relatively high efficiency is obtained for unsteady and steady, well-resolved and under-resolved simulations.