bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Significant Hyperopia in Preschool Children Using Two Automated Vision Screeners
Authors: Maguire Maureen G. , Ying Gui-shuang , Ciner Elise B. , Kulp Marjean Taylor , Candy T. Rowan , Moore Bruce ,   for the Vision in Preschoolers (VIP) Study Group
Published: December 2021

SIGNIFICANCE
Moderate to high uncorrected hyperopia in preschool children is associated with amblyopia, strabismus, reduced visual function, and reduced literacy. Detecting significant hyperopia during screening is important to allow children to be followed for development of amblyopia or strabismus and implementation of any needed ophthalmic or educational interventions.

PURPOSE
This study aimed to compare the sensitivity and specificity of two automated screening devices to identify preschool children with moderate to high hyperopia.

METHODS
Children in the Vision in Preschoolers (VIP) study were screened with the Retinomax Autorefractor (Nikon, Inc., Melville, NY) and Plusoptix Power Refractor II (Plusoptix, Nuremberg, Germany) and examined by masked eye care professionals to detect the targeted conditions of amblyopia, strabismus, or significant refractive error, and reduced visual acuity. Significant hyperopia (American Association for Pediatric Ophthalmology and Strabismus definition of hyperopia as an amblyopia risk factor), based on cycloplegic retinoscopy, was >4.00 D for age 36 to 48 months and >3.50 D for age older than 48 months. Referral criteria from VIP for each device and from a distributor (PediaVision) for the Power Refractor II were applied to screening results.

RESULTS
Among 1430 children, 132 children had significant hyperopia in at least one eye. Using the VIP referral criteria, sensitivities for significant hyperopia were 80.3% for the Retinomax and 69.7% for the Power Refractor II (difference, 10.6%; 95% confidence interval, 7.0 to 20.5%; P = .04); specificities relative to any targeted condition were 89.9 and 89.1%, respectively. Using the PediaVision referral criteria for the Power Refractor, sensitivity for significant hyperopia was 84.9%; however, specificity relative to any targeted condition was 78.3%, 11.6% lower than the specificity for the Retinomax. Analyses using the VIP definition of significant hyperopia yielded results similar to when the American Association for Pediatric Ophthalmology and Strabismus definition was used.

DISCUSSION
When implementing vision screening programs for preschool children, the potential for automated devices that use eccentric photorefraction to either miss detecting significant hyperopia or increase false-positive referrals must be taken into consideration.
Case Report: Ocular Manifestation of Mantle Cell Lymphoma
Authors: Hafeez Sara , Mancini Alexis , Mega Joseph , Greenberg Paul B. , Siegel Cory , Hunter Amanda 
Published: December 2021

SIGNIFICANCE
Mantle cell lymphoma (MCL) is a rare lymphoma that can present even more rarely in the orbit. Diagnosis, differentiation, and systemic treatment with the help of an oncologist are necessary for improved prognosis. Eye care providers must be vigilant when addressing ocular findings to determine next steps.

PURPOSE
We present a case of presumed orbital fat prolapse confirmed as MCL found on routine eye examination.

CASE REPORT
A 72-year-old White man presented for an annual comprehensive eye examination and was found to have conjunctival elevation in the superior and inferior fornices bilaterally. The patient had stable lymphadenopathy on positron emission tomography/computed tomography imaging 1 week before presentation. Coupled with the patient's recent diagnosis of systemic MCL, there was high suspicion that the conjunctival lesions were malignant. Biopsy of the conjunctival lesion confirmed MCL. A reevaluation of the previous imaging with a neuroradiologist confirmed the presence of orbital lesions consistent with MCL. The patient responded to treatment with low-dose focal radiation therapy.

CONCLUSIONS
Primary eye care providers should be aware of limitations of orbital imaging during routine positron emission tomography and computed tomography scans in those with MCL, and consultation with neuroradiology for image review may be useful if the clinical findings are suspicious.
An innovative approach to using an intensive field course to build scientific and professional skills
Authors: Nicotra Adrienne B. , Geange Sonya R. , Bahar Nur H. A. , Carle Hannah , Catling Alexandra , Garcia Andres , Harris Rosalie J. , Head Megan L. , Jin Marvin , Whitehead Michael R. , Zurcher Hannah , Beckmann Elizabeth A. 
Published: December 2021

AbstractThis paper reports on the design and evaluation of Field Studies in Functional Ecology (FSFE), a two-week intensive residential field course that enables students to master core content in functional ecology alongside skills that facilitate their transition from ‘student’ to ‘scientist’. This paper provides an overview of the course structure, showing how the constituent elements have been designed and refined over successive iterations of the course. We detail how FSFE students: 1. Work closely with discipline specialists to develop a small group project that tests an hypothesis to answer a genuine scientific question in the field; 2. Learn critical skills of data management and communication; and 3. Analyse, interpret and present their results in the format of a scientific symposium. This process is repeated in an iterative ‘cognitive apprenticeship’ model, supported by a series of workshops that name and explicitly instruct the students in ‘hard’ and ‘soft’ skills critical relevant for research and other careers. FSFE students develop a coherent and nuanced understanding of how to approach and execute ecological studies. The sophisticated knowledge and ecological research skills that they develop during the course is demonstrated through high quality presentations and peer-reviewed publications in an open-access, student-led journal. We outline our course structure and evaluate its efficacy to show how this novel combination of field course elements allows students to gain maximum value from their educational journey, and to develop cognitive, affective and reflective tools to help apply their skills as scientists.
Topology and adenocarcinoma cell localization dataset on the labyrinthin biomarker
Authors: Babich Michael , Sharma Ankit , Li Tianhong , Radosevich James A. 
Published: December 2021

AbstractThe discovery and characterization of tumor associated antigens is increasingly important to advance the field of immuno-oncology. Data on the, 1) topology, 2) amino acid (a.a.) homology analyses and 3) cell surface localization are presented as evidence in support of labyrinthin as a pan-adenocarcinoma marker. Multiple bioinformatics tools were used to collectively predict calcium binding domain(s), N-myristoylation sites, kinase II phosphorylation sites, and transmembrane domain(s) with predicted N- and C-termini orientations. Sequence homology comparisons were found and alignments made for labyrinthin (255 a.a.) vs. the intracellular aspartyl/asparaginyl beta-hydroxylase (ASPH; 758 a.a.) and the ASPH-gene related protein junctate (299 a.a.), which are both type II proteins. The epitopes for commonly used MCA 44-3A6 anti-labyrinthin and FB-50 anti-ASPH/junctate antibodies were present in all three proteins. The selective expression of labyrinthin was investigated by third party fluorescent activated cell sorter (FACS) analyses of MCA 44-3A6 binding to non-permeabilized adenocarcinoma and normal cell line models. Labyrinthin was detected on non-permeabilized A549 human lung adenocarcinoma cells, but not on normal WI-38 human lung fibroblasts nor primary cultures of normal human glandular-related cells. Microscopic images of immunofluorescent labelled MCA 44-3A6 binding to A549 cells at random cell cycle stages complement the FACS results by further showing that labyrinthin persisted on the cell surfaces along with some cell internalization within 20 minutes. The dataset presented herein is related to research article: “Labyrinthin: A distinct pan-adenocarcinoma diagnostic and immunotherapeutic tumor specific antigen” by Babich et al., Heliyon, 2022 [1].Specifications TableValue of the dataBecause identification and characterization of neoantigens [3, 4, 5] are rare yet increasingly important for diagnostics and therapeutics, the identification of labyrinthin as a pan-adenocarcinoma target is significant for further study by clinicians and cancer researchers.The data provide a basis to determine to what extent labyrinthin is a distinguishing marker for adenocarcinomas vs. conventional methods.The results indicate that therapeutic strategies can be employed that take advantage of labyrinthin’s convenient presence on adenocarcinoma cell surfaces.The discovery of a calcium binding sequence in labyrinthin provides a basis to research if it is key to explaining the long-known phenomena of elevated calcium and irregular signaling in cancer cells [8, 9].The data reveal a need to explore distinctions between ASPH and labyrinthin, in particular because ASPH [10, 11] and labyrinthin-based treatments have already been FDA approved for clinical trials.
Genetic overlap between idiopathic pulmonary fibrosis and COVID−19
Authors: Allen Richard J , Guillen-Guio Beatriz , Croot Emma , Kraven Luke M , Moss Samuel , Stewart Iain , Jenkins R Gisli , Wain Louise V 
Published: December 2021

AbstractGenome-wide association studies (GWAS) of coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) have identified genetic loci associated with both traits, suggesting possible shared biological mechanisms. Using updated GWAS of COVID-19 and IPF, we evaluated the genetic overlap between these two diseases and identified four genetic loci (including one novel) with likely shared causal variants between severe COVID-19 and IPF. Although there was a positive genetic correlation between COVID-19 and IPF, two of these four shared genetic loci had an opposite direction of effect. IPF-associated genetic variants related to telomere dysfunction and spindle assembly showed no association with COVID-19 phenotypes. Together, these results suggest there are both shared and distinct biological processes driving IPF and severe COVID-19 phenotypes.
Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation
Authors: de la Cerda Roberto , Hokamp Karsten , Roche Fiona , Thompson Georgia , Timouma Soukaina , Delneri Daniela , Bond Ursula 
Published: December 2021

AbstractThe lager yeasts, Saccharomyces pastorianus, are hybrids of Saccharomyces cerevisiae and Saccharomyces eubayanus and are divided into two broad groups, Group I and II. The two groups evolved from at least one common hybridisation event but have subsequently diverged with Group I strains losing many S. cerevisiae chromosomes while the Group II strains retain both sub-genomes. The complex genomes, containing orthologous alleles from the parental chromosomes, pose interesting questions regarding gene regulation and its impact on the fermentation properties of the strains. Superimposed on the presence of orthologous alleles are complexities of gene dosage due to the aneuploid nature of the genomes. We examined the contribution of the S. cerevisiae and S. eubayanus alleles to the gene expression patterns of Group I and II strains during fermentation. We show that the relative expression of S. cerevisiae and S. eubayanus orthologues is positively correlated with gene copy number. Despite the reduced S. cerevisiae content in the Group I strain, S. cerevisiae orthologues contribute to biochemical pathways upregulated during fermentation which may explain the retention of specific chromosomes in the strain. Conversely, S. eubayanus genes are significantly overrepresented in the upregulated gene pool in the Group II strain. Comparison of the transcription profiles of Group I and II strains during fermentation identified both common and unique gene expression patterns, with gene copy number being a dominant contributory factor. Thus, the aneuploid genomes create complex patterns of gene expression during fermentation with gene dosage playing a crucial role both within and between strains.
Social care for the migrant population in Spain: needs and strengths of organisations during the COVID-19 pandemic and infodemic
Authors: Bueno Doral Tamara , Lara María , García‐Castillo Noelia 
Published: December 2021

Purpose
In the past months, the authors have experienced an exceptional global situation that especially affects the most vulnerable population. This paper aims to analyse the needs, strengths and good practices of the organisations that have continued to study with the migrant population during the health crisis. The main objective was to determine how the health, social and communication crisis has affected the management of the organisation itself, the communications with its direct beneficiaries, the communications with the rest of society, as well as the perception that organisations specialised in migration have about how media has communicated the information of COVID-19 and migrant population.

Design/methodology/approach
The authors have circulated a questionnaire with open questions that covered the four dimensions previously mentioned.

Findings
The results show the analysis of the answers of 11 of the most important national and international organisations in the field of migration and refuge that operate in Spain.

Originality/value
Key issues have emerged related not only to the principal management concerns, internal digital communication, the adaptability of external communication and the major effort required to provide information about migration but also to innovative good practices. That other third sector organisations focussed on migration will be able to apply in the future and in other geographic areas.
Mapping research on family business in tourism and hospitality: a bibliometric analysis
Authors: Shekhar Shekhar , Gupta Anjali , Valeri Marco 
Published: December 2021

PurposeThis study aims to map the development of research on family business in tourism and hospitality and provides insights into the key contributors, key areas and current dynamics, and suggests future research directions in the field.Design/methodology/approachThis study uses the Web of Science (WoS) database to identify the 124 articles published in the theme. The study uses bibliometric indicators such as the co-citation network, word co-occurrence network to analyze the publication and citation structure using Science of Science (Sci2), OpenRefine, and Gephi.FindingsThe top authors, top journals and major themes are recognized using bibliometric techniques. The study identifies six keyword clusters: entrepreneurship, innovation, and empirical collaborating with tourism, hospitality, and family business. The country-wise collaboration indicates the lack of research in the eastern hemisphere of the world. The co-authorship shows studies shared among individuals of a few organizations. The trends from bibliographic coupling depict the evolution of research.Research limitations/implicationsThe scope of data collection for the network analysis is limited to the WoS. Incorporating papers from other databases might provide different network structures and insights.Originality/valueThe study is the first of its kind in the theme of family businesses in tourism and hospitality and will contribute to the literature by identifying future research directions.
Comparison of flexural capacity of different hollow slab beams with/without pavement layer reinforced by steel plates
Authors: Liu Long , Wang Lifeng , Xiao Ziwang 
Published: December 2021

PurposeReinforcement of reinforced concrete (RC) beams in-service have always been an important research field, anchoring steel plate in the bottom of the beams is a kind of common reinforcement methods. In actual engineering, the contribution of pavement layer to the bearing capacity of RC beams is often ignored, which underestimates the bearing capacity and stiffness of RC beams to a certain extent. The purpose of this paper is to study the effect of pavement layer on the RC beams before and after reinforcement.Design/methodology/approachFirst, static load experiments are carried out on three in-service RC hollow slab beams, meanwhile, nonlinear finite element models are built to study the bearing capacity of them. The nonlinear material and shear slip effect of studs are considered in the models. Second, the finite element models are verified, and the numerical simulation results are in good agreement with the experimental results. Last, the finite element models are adopted to carry out the research on the influence of different steel plate thicknesses on the flexural bearing capacity and ductility.FindingsThe experimental results showed that pavement layers increase the flexural capacity of hollow slab beams by 16.7%, and contribute to increasing stiffness. Ductility ratio of SPRCB3 and PRCB2 was 30% and 24% lower than that of RCB1, respectively. The results showed that when the steel plate thickness was 1 mm–6 mm, the bearing capacity of the hollow slab beam increased gradually from 2158.0 kN.m to 2656.6 kN.m. As the steel plate thickness continuously increased to 8 mm, the ultimate bearing capacity increased to 2681.0 kN.m. The increased thickness did not cause difference to the bearing capacity, because of concrete crushing at the upper edge.Originality/valueIn this paper, based on the experimental study, the bearing capacity of hollow beam strengthened by steel plate with different thickness is extrapolated by finite element simulation, and its influence on ductility is discussed. This method not only guarantees the accuracy of the bearing capacity evaluation, but also does not require a large number of samples, and has certain economy. The research results provide a basis for the reinforcement design of similar bridges.
Collective action components of low-cost housing: an empirical analysis using Ostrom's SES framework
Authors: Wang Hong Kok , Ling Gabriel Hoh Teck , Shi Xuerui 
Published: December 2021

PurposeTo date, low-cost housing held under the common-property regime is faced with various collective action or management issues in relation to common facilities. Understanding and unpacking key collective action components in a multi-dimensional and systematic fashion that help explain the status quo of the complex low-cost housing management is crucial, particularly in identifying potential factors contributing to the suboptimal self-governing outcome. Therefore, the purpose of this paper is to investigate the collective action of low-cost housing in Malaysia using Ostrom's institutional analysis development and social-ecological system framework (IAD-SES framework) as a theoretical framework.Design/methodology/approachFirst, a mixed-method research design was adopted where issues relating to the management of common properties of low-cost housing were identified in the Malaysian context. Second, the components of Ostrom's IAD framework relevant to collective action were identified. Third, after interviewing six experts in the housing industry via semi-structured interviews, two more components (historical development/adaptability to new environment and ethnicity) were added to the questionnaire survey. From here, 633 respondents who lived in four low-cost housings in Kuala Lumpur from 1,598 households were surveyed in 2012. We then merged the IAD framework with the SES framework. Factor analysis and Cronbach's alpha analysis were conducted to uncover the underlying variables and the social ecological clusters that they belonged.FindingsWith average Cronbach's alpha of 0.83, the seven key SES components identified are able to cumulatively explain 71% variance of local collective action components. Based on the cumulative percentage explained, the top five key SES components are as follows: context (social, economic and political settings); ethnicity; outcome; resource system; and users characteristics.Originality/valueThis study identifies key components related to the collective action issues of low-cost housing management, where two additional components were also suggested to be added to the SES framework. Apart from the theoretical contribution, the study, serving as insights and potential solutions, is also of practical significance to the existing management practices of low-cost housing in Malaysia where policymakers and management corporations may prioritize primary SES components, helping them govern common properties more efficiently.
Research and application of K/S value in stain identification
Authors: Cui Qingbin , Shao Fenjuan 
Published: December 2021

Purpose
The intelligent identification of stains can quickly and accurately identify stains. At present, stains are identified subjectively by appearance, color, taste, feel, location, etc. Color is an important factor in identifying stains. K/S value is used to analyze the color of textile fabric, and it has additivity. The purpose of the study is to explore its application in stain recognition is of great significance to intelligent washing.

Design/methodology/approach
A certain method used to stain the textile, then the K/S value of the textile before and after the stain was analyzed and tested by the color difference instrument. The K/S curve of the stain was calculated by the addition of K/S, and then the stain was identified and distinguished.

Findings
The K/S value of the textile stained with stains could be deducted by the K/S value of the color difference meter. After deducting the base cloth, the K/S curve of the same stain is basically the same. Then the stain can be identified and analyzed.

Research limitations/implications
The K/S value can be used for stain analysis, but it needs to be analyzed and tested in the laboratory.

Practical implications
This study provides a simple method for stains identification.

Originality/value
In addition to common methods of stain identification, such as appearance, color, feel, smell, location, stain removal materials, breaking the substrate, IR, etc., K/S value can be used for stain analysis. Identifying stains and washing them in a targeted way to achieve a better washing effect could provide certain technical support for the development of smart washing and smart home appliances.