bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Xiangbin Prescription in Gastrointestinal Function After Gynecological Abdominal Surgery: a Randomized Controlled Trial
Authors: Wu Yuyan , Lin Jinxuan , Zeng Haiping , Chen Yi , Chen Zhiqiang , Chen Qicheng , Jiang Zhi , Huang Jianling , Cao Lixing 
Published: July 2021

Abstract
Background: Recovery of gastrointestinal function after gynecological abdominal surgery is a major clinical problem. An effective intervention to promote the rapid recovery of gastrointestinal function postoperatively is lacking. This randomized trial investigated whether Xiangbin prescription (XBP) was feasible in terms of efficacy and safety on gastrointestinal function recovery in patients after gynecological abdominal surgery. Methods: A randomized controlled study was conducted, in which 190 patients with gynecological abdominal surgery who met the inclusion and exclusion criteria were enrolled. They were assigned randomly to XBP group, chewing gum group or blank control group, and respectively received the following treatments: took the XBP twice a day, chewed a piece of gum for about 15 minutes each 4 hours, or received conventional western basic treatment, starting on postoperative day 1 until defecation. Three groups were compared in terms of primary outcomes including the time of the first defecation and the time of the first flatus and secondary outcomes including the level of Ghrelin (GHRL) and the incidence of postoperative complications. Meanwhile, the safety of this trial was evaluated. Results: There was no statistical difference in baseline characteristics among the three groups. For the time of the first flatus, XBP group (22.33 ± 6.68 h) showed less time compared with the chewing gum group (23.06 ± 7.37 h), while it was shorter than that in the blank control group (25.86 ± 7.93 h) with significant difference (P < 0.05). As for the time of the first defecation, XBP group (38.65 ± 12.96 h) showed shorter time significantly compared with both the chewing gum group (47.29 ± 14.50 h) and the blank control group (54.01 ± 20.32 h) (P < 0.05). For the postoperative GHRL levels, XBP group was higher than that in the chewing gum group with no significant difference and had more significant improvement of the GHRL levels at postoperative day 3 compared with the blank control group (P < 0.05). For postoperative complications, XBP group had lower incidence than the other two groups but with no significant difference. For safety evaluations, no serious adverse events occurred in the three groups. Conclusions: XBP could promote the recovery of gastrointestinal function after gynecological abdominal surgery and it is overall safe. Trial registration: This trial was retrospectively registered by Chinese Clinical Trial Registry with the identifier number, ChiCTR1900026327, at September 30, 2019. http://www.chictr.org.cn/.
Increased Risk of Malignancy in Patients With Systemic Lupus Erythematosus: Population-based Cohort Study in Korea
Authors: Han Jung-Yong , Kim Hyoungyoung , Jung Sun-Young , Jang Eun Jin , Cho Soo-Kyung , Sung Yoon-Kyoung 
Published: July 2021

Abstract
Background This study aimed to evaluate the crude incidence rates and relative risk of malignancy in Korean patients with SLE.Methods We conducted a retrospective nationwide cohort study using databases from the National Health Insurance Service in Korea. All prevalent SLE patients aged over 19 were identified from January 2012 to December 2014 and observed until the diagnosis of malignancy, death, or end of the study, December 2015. The crude incidence rates (IRs) and standardized incidence ratios (SIRs) of overall and site-specific malignancies in SLE patients were estimated.Results We identified 17,854 SLE patients and during the observation period (60,511 person-years [PYs]), 768 solid malignancies (126.9/10,000 PYs) and 68 haematologic malignancies (11.2/10,000 PYs) occurred in SLE patients. In SLE patients, breast and reproductive system and thyroid cancers occurred predominantly, followed by liver and colon cancers. The SIRs of overall, solid, and haematologic malignancies of SLE patients compared to the general population were 1.8 (95% confidence interval [CI] 1.6-1.9), 1.7 (95% CI 1.5-1.8), and 5.9 (95% CI 4.8-7.3), respectively. In solid malignancies, head and neck (2.7, 95% CI 1.1-4.2), bladder (2.4, 95% CI 1.1-3.8), liver (1.9, 95% CI 1.4-2.3), pancreas (1.9, 95% CI 1.3-2.6), lung (1.8, 95% CI 1.2-2.4), colon (1.7, 95% CI 1.3-2.2), thyroid (1.6, 95% CI 1.3-1.8) and breast and reproductive system (1.5, 95% CI 1.2-1.7) cancers are at increased risk in SLE patients.Conclusion An increased risk of haematologic and solid malignancies was observed in Korean patients with SLE compared to the general population.
A One-Stage Ensemble Framework based on Convolutional Autoencoder for Remaining Useful Life Estimation
Authors: Park Yong-Keun , Kim Min-Kyung , Um Jumyung 
Published: July 2021

Abstract
The research on predictive maintenance of rotating machines, the most important element in manufacturing facilities, has been very active. The widespread availability of smart factory solutions has led to improved data collection from machines and processes and is able to provide key information. For our purpose, the collected information enables the maintenance system to predict the remaining useful life using deep learning models. The introduction of multi-layer perceptron of signal processing originating from bearings, in time series data, has been discussed in many publications. However, estimating accuracy for the remaining useful life is determined by the selection of the feature domain and the concatenation network model. Herein, we introduce a convolutional Autoencoder based on multi-domain ensemble learning in order to include various feature domains and a concatenation network operated by latent space into a single neural network. The performance of the proposed model is evaluated by using a simple health indicator and a PRONOSTIA dataset and compared with a simple concatenation model, 2-stage Autoencoder, and a recurrent neural network.
Elimination of PRRS Using An Inactivated Vaccine in Combination With A Roll-Over Method in A Hungarian Large-Scale Pig Herd
Authors: Pertich Attila , Barna Zoltán , Makai Orsolya , Farkas János , Molnár Tamás , Bálint Ádám , Szabó István , Albert Mihály 
Published: July 2021

Abstract
Background:Four countries are free from the porcine reproductive and respiratory syndrome virus (PRRSV) in Europe, a virus that causes severe economic losses worldwide. A number of countries have initiated eradication programmes against the disease. Among the applied methods, complete depopulation-repopulation is the safest and fastest but at the same time the most expensive process. Another possible way of heard eradication is to replace the infected breading stock by gilts reared PRRSV free on the infected farm. This way maintaining continued farm production. In this paper, the authors present a successful complex method of eradication (including the application of an inactivated vaccine and segregated rearing of offspring) in a Hungarian large scale pig farm. Case presentation:A farm of 1475 sows (Farm A) was infected with PRRSV and the clinical signs of reproductive failure were eliminated by using an inactivated vaccine (Progressis®, Ceva). At the beginning of eradication, gilts selected for breeding were vaccinated at 60 and 90–100 days of age, respectively. The subsequent vaccinations of breeding animals were applied at 6 months of age, on the 60–70th day of pregnancy and at weaning. The 7weeks-old piglets of the vaccinated sows, approximately 1200 piglets were transported in groups of 300 animals to a closed, empty farm (Farm B) after a testing negative with PCR, and they were reared here until 14 weeks of age. These seronegative gilts were subsequently transported to a third, closed, empty farm (Farm C), and (having reached the breeding age) they were inseminated here after a negative serological test (ELISA). At the same time, Farm A was depopulated, cleaned and disinfected. All pregnant gilts were transported from Farm C to Farm A after being tested negative with ELISA, where follow-up was performed after farrowing by two serological tests with an interval of six months. Based on the subsequent negative test results, the competent authority declared the herd PRRSV free. Conclusions:The farm presented in this study was the first in the course of the National PRRS Eradication Programme to eradicate PRRSV successfully by vaccinating the sows with an inactivated vaccine and performing segregated rearing of the offspring. Production was almost continuous during the whole process of the population replacement. Testing for monitoring purposes was also cheaper and simpler because of the use of an inactivated vaccine.
Adaptive CNC Machining Process Optimization of Near- net- shaped Blade based on Machining Error data Flow Control
Authors: Wu Dongbo , hui wang , lei he , Yu Jie 
Published: July 2021

Abstract
Adaptive CNC machining process is one of the efficient processing solution for near- net- shaped blade, this study proposes an adaptive computer numerical control (CNC) machining process optimization scheme based on multi-process machining errors data flow control. The geometric and mechanical models of the multi-process adaptive CNC machining process are firstly constructed. The multi-process machining error data flow and the process system stiffness of near- net- shaped blade are then experimentally explored. The machining error flow collaborative control of the near- net- shaped blade multi-process CNC machining is finally realized by the adaptive CNC machining process under the premise of sufficient stiffness of the blade- fixture system. The results show that the dynamic displacement response of the blade multi-process CNC machining process is controlled within 0.007mm. The optimized adaptive CNC machining process based on the multi-process geometric machining error data flow control and the sufficient stiffness of blade- fixture system can realize the multi-process machining error control and high-precision machining of near- net- shaped blade. The process chain of the optimized adaptive CNC machining process is reduced by 87% compared with the low melting point alloy pouring process and 50% compared with adaptive CNC machining process of the twice on-machine measurement on the blade body.
Prognostic Influence of Spontaneous Tumor Rupture in Patients with Hepatocellular Carcinoma After Hepatectomy: A Meta-Analysis of Observational Studies
Authors: Xu Jiaxuan , Gu Lihu , Xu Binbin , Si Yuexiu , He Yujing , Chen Ping 
Published: July 2021

Abstract
Background: This study aims to comprehensively analyze the influence of spontaneous tumor rupture on the prognosis of hepatocellular carcinoma patients following hepatic resection.Methods: We systematically searched four online electronic databases, including PubMed, Embase, Web of Science, and Cochrane Library, for eligible studies published from inception to March 2021. The main endpoints were overall survival (OS) and disease-free survival (DFS).Results: This meta-analysis included 21 observational articles with 57241 cases. The results revealed that spontaneous tumor rupture was associated with worse OS (hazard ratio (HR), 1.65; 95% confidence interval (CI), 1.33-2.05) and DFS (HR, 1.42; 95% CI, 1.12-1.80) in resectable hepatocellular carcinoma patients. This phenomenon was observed in most subgroups, which were classified by recorded survival time, age, country, alpha-fetoprotein (AFP) concentration, liver cirrhosis, and microvascular invasion. However, in subgroups of macrovascular invasion positive, spontaneous tumor rupture was not a risk factor for OS (HR, 1.55; 95% CI, 0.99-2.42) and DFS (HR, 1.23; 95% CI, 0.91-1.65) in hepatocellular carcinoma patients after hepatectomy. For macrovascular invasion negative, compared with non-ruptured hepatocellular carcinoma patients, ruptured hepatocellular carcinoma patients exhibited worse prognosis for OS (HR, 1.55; 95% CI, 0.99-2.42) and DFS (HR, 1.23; 95% CI, 0.91-1.65) following hepatectomy.Conclusions: Spontaneous tumor rupture was a prognostic risk factor for hepatocellular carcinoma patients after hepatic resection. However, in macrovascular invasion patients, spontaneous tumor rupture was not a prognostic risk factor.
A Tentative Study of Individual Puncture Path of PVP/ PKP in Treating OVCFs
Authors: Guo Sheng , Xiao Changming , Wang Chenglong , Li Sen 
Published: July 2021

Abstract
Background: The prior objective of this study is to discuss individualized puncture path of percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) in the treatment of the elderly with severe osteoporotic vertebral compression fractures (OVCFs).Previous studys have compared the clinical efficacy and safety of PVP and PKP. Based on their research results, we will make a further investigation about this two main operations in treating OVCFs and propose a set of original and feasible puncture plan in clinical work, which will improve efficiency and safety of PKP and PVP.Methods: We searched all the articles related to PVP and PKP in treating OVCFs on medicine database. Issues of the selected journals published from 1999 to 2020 were hand-searched by us, including experimental or review articles. Combining conclusions of these researches and clinical cases of our department, we are forged to find more common and preferred treatments for patients with OVCFs under different situations.Results: Most of thees studies revealed that there was no significant difference in relieving the back pain and improving the quality of patients’ life between PVP and PKP surgeries, which generally based on the VAS scores and Oswestry disability index(ODI) scores. However, PKP has a lower rate of bone cement leakage and incidence of adjacent vertebrae fracture than the PVP. Restoring the vertebral height and local kyphotic angle corrections of PKP are much better than that of PVP. On the other hand, more operation time, higher cost and rate of re-surgery of PKP should also be taken into consideration when we make better choice for patients. Therefore, we are forged to find individual methods for patients who are diagnosed as OVCFs.Conclusions: Both the two types of operation can significantly relieve the pain of the patients ,reduce the risk of occurring complication and mortality after OVCFs. There is no so-called best treatment for patients between PVP and PKP. We should take the comprehensive actual conditions into account when choosing surgical methods for patients with OVCFs, which is absolutely vital to us. However, individual puncture path is beneficial for us to make operations including both PKP and PVP.
In-depth Proteomic Profiling Captures Subtype-specific Features of Craniopharyngiomas
Authors: Kim Jung Hee , Kim Hyeyoon , Dan Kisoon , Kim Seong-Ik , Park Sung-Hye , Han Dohyun , Kim Yong Hwy 
Published: July 2021

Abstract
Purpose: Craniopharyngiomas are rare epithelial tumors derived from pituitary gland embryonic tissue. This epithelial tumor can be categorized as an adamantinomatous craniopharyngioma (ACP) or papillary craniopharyngioma (PCP) subtype with histopathological and genetic differences. Genomic and transcriptomic profiles of craniopharyngiomas have been investigated; however, the proteomic profile has yet to be elucidated and added to these profiles. Recent improvements in high-throughput quantitative proteomic approaches have introduced new opportunities for a better understanding of these diseases and the efficient discovery of biomarkers. We aimed to confirm subtype-associated proteomic changes between ACP and PCP specimens.Methods: We performed a system-level proteomic study using an integrated approach that combines mass spectrometry-based quantitative proteomic, statistical, and bioinformatics analyses.Results: The bioinformatics analysis showed that differentially expressed proteins between ACP and PCP were significantly involved in mitochondrial organization, fatty acid metabolic processes, exocytosis, the inflammatory response, the cell cycle, RNA splicing, cell migration, and neuron development. Furthermore, using network analysis, we identified hub proteins that were positively correlated with ACP and PCP phenotypes.Conclusions: Our findings improve our understanding of the pathogenesis of craniopharyngiomas and provide novel insights that may ultimately translate to the development of craniopharyngioma subtype-specific therapeutics.
Comparison of the Posterior-anterior Approach and Lateral-medial Approach for Complex AO/OTA Type C Intra-articular Fractures of Distal Humerus
Authors: Chen Yongchang , Xiao Fei , Chen Jian , Wei Lin , Zheng Guoqing , Wei Zhongsheng , Li Jingpu , Tu Jialei , Wang Gang , Wang Xiao , Xu Haibo 
Published: July 2021

Abstract
Objective: The aim of this retrospective study was to investigate clinical effects of the treatment of intra-articular distal humeral fractures via the combined posterior olecranon osteotomy and anterior approach and the combined lateral Kaplan approach associated with the medial approach. Methods: Between July 2010 and September 2019, 28 cases of intercondylar fractures of the distal humerus (AO/OTA type C) were treated by open reduction and internal fixation (ORIF) via the posterior and anterior approach and combined lateral-medial approach, which were divided into the P-A (n = 13) and L-M (n = 15) groups, respectively. The outcomes in terms of function were assessed using the range of motion (ROM) of the elbow and forearm, humerotrochlear (HT) angle, Visual Analogue Scale (VAS) scores, Mayo Elbow Performance Score (MEPS), and efficacy grade evaluated using the scoring system of Orthopaedic Trauma Association (OTA) at the one-year follow-up. Results: The ﬂexion-extension of elbows and pronation-supination of forearms were respectively 114.1° ± 12.4° and 157.3° ± 9.6° in the P-A group and 117.1° ± 14.5° and 161.3° ± 10.7° in the L-M group. No significant diﬀerence was observed between the two groups for the elbow and forearm ROM (p > 0.05). Furthermore, surgery duration, blood loss volume, HT angle, MEPS, VAS scores, OTA rating, and the morbidity of postoperative complications during the one-year follow-up did not differ between groups. Conclusion: The posterior olecranon osteotomy and anterior approach can be used efficiently for exposure of complex distal humeral injuries with similar clinical efficacy and complications in the treatment of intra-articular distal humeral fractures as compared to the lateral-medial approach.
AGAR a Microbial Colony Dataset for Deep Learning Detection
Authors: Majchrowska Sylwia , Pawlowski Jaroslaw , Gula Grzegorz , Bonus Tomasz , Hanas Agata , Loch Adam , Pawlak Agnieszka , Roszkowiak Justyna , Golan Tomasz , Drulis-Kawa Zuzanna 
Published: July 2021

Abstract
The Annotated Germs for Automated Recognition (AGAR) dataset is an image database of microbial colonies cultured on agar plates. It contains 18 000 photos of five different microorganisms as single or mixed cultures, taken under diverse lighting conditions with two different cameras. All the images are classified into countable, uncountable, and empty, with the countable class labeled by microbiologists with colony location and species identification (336 442 colonies in total). This study describes the dataset itself and the process of its development. In the second part, the performance of selected deep neural network architectures for object detection, namely Faster R-CNN and Cascade R-CNN, was evaluated on the AGAR dataset. The results confirmed the great potential of deep learning methods to automate the process of microbe localization and classification based on Petri dish photos. Moreover, AGAR is the first publicly available dataset of this kind and size and will facilitate the future development of machine learning models. The data used in these studies can be found at https://agar.neurosys.com/.
Integrated Analysis of Dysregulated microRNA and mRNA Expression in Intestinal Epithelial Cells following Ethanol Intoxication and Burn Injury
Authors: Herrnreiter Caroline , Li Xiaoling , Luck Marisa , Zilliox Michael , Choudhry Mashkoor 
Published: July 2021

Abstract
Gut barrier dysfunction is often implicated in pathology following alcohol intoxication and burn injury. MicroRNAs (miRNAs) are negative regulators of gene expression that play a central role in gut homeostasis, although their role after alcohol and burn injury is poorly understood. We performed an integrated analysis of miRNA and RNA sequencing data to identify a network of interactions within small intestinal epithelial cells (IECs) which could promote gut barrier disruption. Mice were gavaged with ~ 2.9 g/Kg ethanol and four hours later given a ~ 12.5% TBSA full thickness scald injury. One day later, IECs were harvested and total RNA extracted for RNA-seq and miRNA-sEq. RNA sequencing showed 712 differentially expressed genes (DEGs) (padj < 0.05) in IECs following alcohol and burn injury. Furthermore, miRNA sequencing revealed 17 differentially expressed miRNAs (DEMs) (padj < 0.1). Utilizing the miRNet, miRDB and TargetScan databases, we identified both validated and predicted miRNA gene targets. Integration of small RNA sequencing data with mRNA sequencing results identified correlated changes in miRNA and target expression. Overall, these findings suggest that alcohol and burn injury significantly alters the mRNA and miRNA expression profile of IECs and reveals numerous miRNA-mRNA interactions that regulate critical pathways for gut barrier function after alcohol and burn injury.
Effect of Workplace Stress on the Perceived Health of Resident Doctors Nigeria
Authors: Alao Adegboyega Olalekan , Obimakinde Abimbola , Ogunbode Adetola 
Published: July 2021

Abstract
The objective of this study was to assess workplace stress among the resident doctors, examine their perceived health status, and determine the effect of workplace stress on their perceived health status.The study was a cross-sectional study conducted among resident doctors at University College Hospital (UCH), Ibadan Nigeria across all the specialties over a three-month period, from 1st March to 31st May, 2019. Two hundred and thirty-two eligible and consenting resident doctors were selected by stratified random sampling and data was collected using interviewer administered questionnaire. Data was analyzed using the Statistical Package for the Social Sciences (SPSS) version 23.Results showed the 144 (62.1%) of the resident doctors experienced workplace stress and 108 (46.6%) resident doctors perceived their health as poor. Workplace stress, years in residency program, designation, and work hours on least busy day at work were all significantly associated with perceived health status of the resident doctors, however, only workplace could independently predict poor perceived health status of the resident doctors.It is therefore important to prevent and mange workplace stress in order to improve the perceived status of resident doctors.