bluuebunny/crossref_metadata_2025_split huggingface dataset:
Programmed Death Ligand 2 Gene Polymorphisms Are Associated With Lung Adenocarcinoma Risk in Female Never-Smokers
Authors: Liang Sheng-Kai , Chien Li-Hsin , Chang Gee-Chen , Tsai Ying-Huang , Su Wu-Chou , Chen Yuh-Min , Huang Ming-Shyan , Lin Hsien-Chih , Fang Wen-Tsen , Hung Hsiao-Han , Jiang Shih-Sheng , Chen Chih-Yi , Chen Kuan-Yu , Chang I-Shou , Hsiung Chao A. , Chen Chien-Jen , Yang Pan-Chyr ,   the GELAC Study Group
Published: September 2021

ObjectivesLung cancer in never-smokers is a distinct disease associated with a different genomic landscape, pathogenesis, risk factors, and immune checkpoint inhibitor responses compared to those observed in smokers. This study aimed to identify novel single nucleotide polymorphisms (SNPs) of programmed death-1 (encoded by PDCD1) and its ligands, programmed death ligand 1 (CD274) and 2 (PDCD1LG2), associated with lung cancer risk in never-smoking women.Materials and MethodsDuring September 2002 and July 2012, we enrolled never-smoking female patients with lung adenocarcinoma (LUAD) (n=1153) and healthy women (n=1022) from six tertiary hospitals in Taiwan. SNP data were obtained and analyzed from the genome-wide association study dataset and through an imputation method. The expression quantitative trait loci (eQTL) analysis was performed in both tumor and non-tumor tissues for the correlation between genetic expression and identified SNPs.ResultsA total of 12 PDCD1LG2 SNPs related to LUAD risk were identified in never-smoking women, including rs2381282, rs4742103, rs4237162, rs4742104, rs12237624, rs78096119, rs6476988, rs7857315, rs10975178, rs7854413, rs56001683, and rs7858319. Among them, six tagged PDCD1LG2 SNPs rs2381282, rs4742103, rs4237162, rs4742104, rs78096119, and rs56001683 were significantly associated with LUAD risk. Specifically, two PDCD1LG2 SNPs, rs12237624 and rs78096119, were associated with previous pulmonary tuberculosis infection in relation to LUAD susceptibility. Through an eQTL assay, we found that rs2381282 (p &lt; 0.001), rs12237624 (p = 0.019), and rs78096119 (p = 0.019) were associated with the expression levels of programed death ligand 2.ConclusionsNovel SNPs of programed death ligand 2 associated with lung adenocarcinoma risk were identified. Among them, two SNPs were associated with pulmonary tuberculosis infection in relation to lung adenocarcinoma susceptibility. These SNPs may help to stratify high-risk populations of never-smokers during lung cancer screening.
Identification of Two de novo Variants of CACNA1A in Pediatric Chinese Patients With Paroxysmal Tonic Upgaze
Authors: Zhang Li-Ping , Jia Yu , Wang Yu-Ping 
Published: September 2021

Objective: Investigate the clinical manifestations and genotypes of paroxysmal tonic upgaze (PTU) in Chinese children.Patients and Methods: We report the clinical manifestations and genetic test results of four pediatric PTU patients in China. Recent articles on PTU cases are also summarized and analyzed.Results: The onset age of all four cases was at early infancy, and they presented as episodic binocular upward gaze with mild growth retardation. Two patients each carried a novel de novo variant in the CACNA1A gene, c.4046C&gt;T (p.R1349X), and c.4415C&gt;T (p.S1472L).Conclusion: Patients with infantile-onset paroxysmal binocular upward gaze should be considered to diagnose as PTU.
Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome
Authors: Chang Ching-Mao , Wu Po-Chang , Lin Jr-Rung , Jan Wu Yeong-Jian , Luo Shue-Fen , Hsue Yin-Tzu , Lan Joung-Liang , Pan Tai-Long , Wu Yu-Ting , Yu Kuang-Hui , Wei Yau-Huei , Chang Hen-Hong 
Published: September 2021

Background: Sjögren’s syndrome (SS) is an autoimmune inflammatory disease that primarily affects the exocrine glands, leading to glandular dysfunction. The hallmark symptoms of SS are dry eyes and mouth, compromising the quality of life of patients and decreasing their capacity to perform their daily activities.Objective: This study aims to evaluate the efficacy of the herbal formula SS-1 for its potential therapeutic benefits for patients with Sjögren’s syndrome.Materials and Methods: The bioactivity profile of SS-1 was determined using four different SS-1 concentrations across 12 human primary cell systems of the BioMAP profile. After that, a randomized, double-blind, crossover, placebo-controlled trial was performed including 57 patients treated with SS-1 for 28 weeks.Results: Biologically multiplexed activity profiling in cell-based models indicated that SS-1 exerted anti-proliferative activity in B cells and promoted anti-inflammatory and immunomodulatory activity. In the clinical trial, Schirmer’s test results revealed significant improvements in both eyes, with increases of 3.42 mm (95% CI, 2.44–4.41 mm) and 3.45 mm (95% CI, 2.32–4.59 mm), respectively, and a significant reduction in artificial tear use, which was −1.38 times/day, 95% CI, −1.95 to −0.81 times/day. Moreover, the increases in B-cell activating factor (BAFF) and B-cell maturation antigen (BCMA) levels were dampened by 53.20% (295.29 versus 555.02 pg/ml) and 58.33% (99.16 versus 169.99 pg/ml), respectively.Conclusion: SS-1 treatment significantly inhibited B-cell maturation antigen. No serious drug-related adverse effects were observed. Oral SS-1 administration may be a complementary treatment for Sjögren’s syndrome.
Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis Via Activation of β-Catenin Signaling in Growth Plate Chondrocytes
Authors: Xu Rui , Zeng Qinghe , Xia Chenjie , Chen Jiali , Wang Pinger , Zhao Shan , Yuan Wenhua , Lou Zhaohuan , Lin Houfu , Xia Hanting , Lv Shuaijie , Xu Taotao , Tong Peijian , Gu Mancang , Jin Hongting 
Published: September 2021

Background: Shen-sui-tong-zhi formula (SSTZF) has been used to treat osteoporosis for decades and shows excellent clinical efficacy. This article aims to explore the optimal anti-osteoporotic ingredient and its precise mechanisms in mice models.Methods: In this study, we first screened the optimal anti-osteoporosis fraction of SSTZF extract in vivo, and then further explored the mechanism of its effects both in vivo and in vitro. Ten-week-old female C57BL/6J mice were administrated with each fraction of SSTZF. At 10 weeks after ovariectomy (OVX), femurs were collected for tissue analyses, including histology, micro-CT, biomechanical tests, and immunohistochemistry for ALP, FABP4, and β-catenin. Additionally, we also evaluated the mRNA expression level of ALP and FABP4 and the protein expression level of β-catenin after being treated with SSTZF extract in C3H10T1/2 cells. Moreover, we investigated the anti-osteoporosis effect of SSTZF extract on mice with β-catenin conditional knockout in growth plate chondrocytes (β-cateninGli1ER mice) through μCT, histology, and immunohistochemistry analyzes.Results: At 10 weeks after treatment, osteoporosis-like phenotype were significantly ameliorated in SSTZF n-butanol extract (SSTZF-NB) group mice, as indicated by increased trabecular bone area and ALP content, and decreased lipid droplet area and FABP4 content. No such improvements were observed after being treated with other extracts, demonstrating that SSTZF-NB is the optimal anti-osteoporosis fraction. Additionally, the elevated β-catenin was revealed in both OVX mice and C3H10T1/2 cells with SSTZF-NB administered. Furthermore, a significant osteoporosis-like phenotype was observed in β-cateninGli1ER mice as expected. However, SSTZF-NB failed to rescue the deterioration in β-cateninGli1ER mice, no significant re-upregulated ALP and downregulated FABP4 were observed after being treated with SSTZF-NB, demonstrating that SSTZF-NB prevents bone loss mainly via β-catenin signaling.Conclusion: SSTZF-NB enhances osteogenesis mainly via activation of β-catenin signaling in growth plate chondrocytes. SSTZF-NB is the optimal anti-osteoporosis fraction of SSTZF and it can be considered a salutary alternative therapeutic option for osteoporosis.
Tailorable Stimulated Brillouin Scattering Laser Based on Silicon Ring Waveguides
Authors: Wang Yulei , Li Kai , Yu Yu , Li Sensen , Li Yunfei , Wang Wuyue , Song Changyu , Wang Zhiyong , Wang Gong , Zhang Yong , Lu Zhiwei , Li Yuhai , Liu Tongyu , Yan Xiusheng 
Published: September 2021

Stimulated Brillouin scattering (SBS) lasers based on silicon waveguides with large SBS gain, have been widely used in frequency tunable laser emission, mode-locked pulse laser, low-noise oscillator, optical gyroscope, and other fields. However, current SBS lasers still need long waveguide lengths to realize Brillouin laser output, which increases the waveguide losses and is not conductive to be integrated. In this paper, we propose a silicon ring waveguide, in order to tune the frequency of the phonon field of SBS laser based on the silicon substrate of the ring cavity. The simulation results exhibit that the tailorable forward SBS effect is realized in the silicon-based optical waveguide with a large SBS gain up to 1.90 W-1m-1. Particularly, with the mutual restraint between photoelastic and moving boundary effects, the tunable phonon frequencies emitting from 1 to 15 GHz are realized through the conversion among higher order modes by modifying the widths of the ring cavity. Therefore, this silicon waveguide based on ring cavity will provide a new technical scheme for designing tunable SBS lasers by tuning the ring widths. In addition, this enhanced and broadband acoustic radiation will pave the way for hybrid integration in silicon-based optical waveguide, micro-electromechanical system, and CMOS signal processing technology.
Secondhand Smoke Decreased Excitability and Altered Action Potential Characteristics of Cardiac Vagal Neurons in Mice
Authors: Sun Junqing , Pan Shiyue , Karey Emma , Chen Yi-Je , Pinkerton Kent E. , Wilson Christopher G. , Chen Chao-Yin 
Published: September 2021

Background: Secondhand smoke (SHS), a major indoor pollutant, is a significant risk factor for cardiovascular morbidity and mortality including arrhythmias and sudden cardiac death. Exposure to SHS can produce autonomic imbalance, as evidenced by reduced heart rate variability (HRV)—a clinical metric of cardiac vagal regulation. Currently, the mechanisms through which SHS changes the vagal preganglionic neuronal inputs to the heart to produce this remains unknown.Objectives: To characterize the effect of SHS on both the excitability and action potential (AP) characteristics of anatomically identified cardiac vagal neurons (CVNs) in the nucleus ambiguus and examine whether SHS alters small conductance calcium-activated potassium (SK) channel activity of these CVNs.Methods: Adult male mice were exposed to four weeks of filtered air or SHS (3 mg/m3) 6 h/day, 5 day/week. Using patch-clamp recordings on identified CVNs in brainstem slices, we determined neuronal excitability and AP characteristics with depolarizing step- and ramp-current injections.Results: Four weeks of SHS exposure reduced spiking responses to depolarizing current injections and increased AP voltage threshold in CVNs. Perfusion with apamin (20 nM) magnified these SHS-induced effects, suggesting reduced SK channel activity may serve to minimize the SHS-induced decreases in CVNs excitability. Medium afterhyperpolarization (a measurement of SK channel activity) was smaller in the SHS group, further supporting a lower SK channel activity. AP amplitude, rise rate, fast afterhyperpolarization amplitude (a measurement of voltage-gated channel activity), and decay rate were higher in the SHS group at membrane voltages more positive to 0 mV, suggesting altered inactivation properties of voltage-dependent channels underlying APs.Discussion: SHS exposure reduced neuronal excitability of CVNs with compensatory attenuation of SK channel activity and altered AP characteristics. Neuroplasticity of CVNs could blunt regulatory cardiac vagal signaling and contribute to the cardiovascular consequences associated with SHS exposure, including reduced HRV.
Nocturnal Hypoxemia Rather Than Obstructive Sleep Apnea Is Associated With Decreased Red Blood Cell Deformability and Enhanced Hemolysis in Patients With Sickle Cell Disease
Authors: Stauffer Emeric , Poutrel Solène , Cannas Giovanna , Gauthier Alexandra , Fort Romain , Bertrand Yves , Renoux Céline , Joly Philippe , Boisson Camille , Hot Arnaud , Peter-Derex Laure , Pialoux Vincent , PetitJean Thierry , Connes Philippe 
Published: September 2021

Background: Although obstructive sleep apnea (OSA) could act as a modulator of clinical severity in sickle cell disease (SCD), few studies focused on the associations between the two diseases.Research Question: The aims of this study were: (1) to explore the associations between OSA, nocturnal oxyhemoglobin saturation (SpO2) and the history of several acute/chronic complications, (2) to investigate the impact of OSA and nocturnal SpO2 on several biomarkers (hematological, blood rheological, and coagulation) in patients with SCD.Study Design and Methods: Forty-three homozygous SCD patients underwent a complete polysomnography recording followed by blood sampling.Results: The proportion of patients suffering from nocturnal hypoxemia did not differ between those with and those without OSA. No association between OSA and clinical severity was found. Nocturnal hypoxemia was associated with a higher proportion of patients with hemolytic complications (glomerulopathy, leg ulcer, priapism, or pulmonary hypertension). In addition, nocturnal hypoxemia was accompanied by a decrease in RBC deformability, enhanced hemolysis and more severe anemia.Interpretation: Nocturnal hypoxemia in SCD patients could be responsible for changes in RBC deformability resulting in enhanced hemolysis leading to the development of complications such as leg ulcers, priapism, pulmonary hypertension or glomerulopathy.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03753854.
Acupuncture for Psychosomatic Symptoms of Hwa-byung, an Anger Syndrome: A Feasibility Randomized Controlled Trial
Authors: Choi Yujin , Park In-Hye , Kim Jung-Eun , Kwon Ojin , Kim Ae-Ran , Park Hyo-Ju , Lee Jun-Hwan , Kim Joo-Hee 
Published: September 2021

Objectives: Emerging studies found the potential effects of acupuncture for treating chronic pain and mental disorders, namely, depressive and anxiety disorders. Acupuncture is widely used for treating culture-related anger syndrome, Hwa-byung. This pilot trial aimed to investigate the feasibility of a clinical trial testing acupuncture for the psychosomatic symptoms of Hwa-byung.Methods: A total of 26 patients with Hwa-byung planned to be randomly assigned to the acupuncture or sham acupuncture groups. About 10 treatment sessions were applied over 4 weeks. The 100-mm visual analog scale was used to measure the six major Hwa-byung symptoms: stuffiness in the chest, heat sensations, pushing-up in the chest, feeling a mass in the throat, feelings of unfairness, and hard feelings. The criteria for assessing the success of this pilot trial were defined as improvement in three or more of the six Hwa-byung symptoms after treatment, with an effect size &gt;0.2.Results: A total of 15 patients were finally included and randomly assigned to the acupuncture group (n = 7) or the sham acupuncture group (n = 8). After 10 treatment sessions, the Cohen's d effect sizes for acupuncture compared to sham acupuncture were &gt;0.2 for each one of the six major Hwa-byung symptoms, which met our a priori criteria for success. Also, the effect size for the somatic symptoms of “stuffiness in the chest” was 0.81 (95% CI −0.40, 2.20), referring to a large effect size.Conclusions: Our results suggest that acupuncture treatment would be regarded as an acceptable intervention for a full-scale study of psychosomatic symptoms in patients with Hwa-byung.Trial Registration:cris.nih.go.kr, identifier: KCT0001732.
Self-Monitoring of Balance Performance can Reduce the Rate of Falls Among Older Adults
Authors: Forth Katharine E. , Layne Charles S. , Madansingh Stefan I. 
Published: September 2021

Background: 29% of older adults fall annually, resulting in the leading cause of accidental death. Fall prevention programs typically include exercise training and self-monitoring of physical activity has a positive effect on the self-efficacy and self-regulation of exercise behaviors. We assessed if self-monitoring of fall risk, without an intervention, impacts fall rates.Methods: Fifty-three older adults had open access to a balance measuring platform which allowed them to self-monitor their postural stability and fall risk using a simple 1-min standing balance test. 12-month retrospective fall history was collected and a monthly/bimonthly fall log captured prospective falls. Participants had access to self-monitoring for up to 2.2 years. Fall history and fall incidence rate ratios and their confidence intervals were compared between the periods of time with and without access to self-monitoring.Results: A 54% reduction in the number of people who fell and a 74% reduction in the number of falls was observed when participants were able to self-monitor their postural stability and fall risk, after normalizing for participation length. Further, 42.9% of individuals identified as having high fall risk at baseline shifted to a lower risk category at a median 34 days and voluntarily measured themselves for a longer period of time.Discussion: We attribute this reduction in falls to changes in health behaviors achieved through empowerment from improved self-efficacy and self-regulation. Providing older adults with the ability to self-monitor their postural stability and intuit their risk of falling appears to have modified their health behaviors to successfully reduce fall rates.
Exploring Trends and Differences in Health Behaviours of Health Sciences University Students from Germany and England: Findings from the “SuSy” Project
Authors: Kalbus Alexandra , Boenecke Juliane , Holt Maxine , Powell Susan , Reintjes Ralf 
Published: September 2021

Objectives: This research aimed to explore the health behaviours of health sciences students over time and across different settings.Methods: A health behaviour surveillance system has been implemented in Hamburg and Manchester among under- and postgraduate health sciences students. Trends among the Hamburg sample were described. In a cross-sectional assessment, health behaviours across both universities were examined using multivariate regression analysis.Results: Between 2014 and 2018, increasing trends in physical activity and cannabis and alcohol consumption were observed in Hamburg (n = 1,366). While fruit and vegetable intake was constantly low, tobacco smoking decreased. No clear trend was observed for stress perception. The comparison (n = 474) revealed that Manchester students had higher odds of smoking, excessive alcohol consumption, and fruit and vegetable consumption; and lower odds of being physically active, and consuming cannabis. No difference in stress perception was observed.Conclusions: Varying trends and potential areas of intervention were identified for health behaviours in Hamburg. The comparison with Manchester students revealed differences in behaviours, which could be further explored to help inform health promotion strategies in both settings.
PENGARUH KUALITAS PRODUK DAN LABEL HALAL TERHADAP KEPUTUSAN PEMBELIAN PRODUK (Study Kasus Pada Mahasiswa IAIN Salatiga)
Authors: Thousani Hifzhan Frima 
Published: September 2021

Penelitian ini mempunyai tujuan untuk mengetahui pengaruh kualitas produk dan label halal terhadap keputusan pembelian kosmetik wardah. Dalam penelitian ini menggunakan data primer dengan cara penyebaran kuisioner. Ukuran sampel dalam penelitian ini sebanyak 100 responden yang merupakan konsumen produk wardah. Penelitian ini menggunakan explanatory research yang menggunakan pendekatan kuantitatif dengan uji validitas, uji reabilitas, uji t dan uji F. Hasil penelitian ini menunjukkan bahwa keputusan pembelian kosmetik wardah dipengaruhi secara positif signifikan oleh kualitas produk dan label halal. Rekomendasi yang dihasilkan dari penelitian ini adalah perusahaan harus tetap mempertahankan kualitas yang sudah baik dan terus menyempurnakannya untuk menjaga loyalitas konsumen setia produk kosmetik wardah.
PENGARUH KELOMPOK REFERENSI DAN BUDAYA TERHADAP KEPUTUSAN MENJADI ANGGOTA SANGGAR TARI
Authors: Sutiana Elvira Pradipta , Sari Risha Fatikha , Sudrajat Ajat 
Published: September 2021

"The Influence of Reference Groups and Culture on the Decision to Become Members of the Dance Studio" under the guidance of Ajat Sudrajat, SE., MM.
The consumer behaviour in making purchasing decisions can be influenced by three factors including internal factors, external factors, and the decision-making process. The study entitled "The Influence of Reference Group and Culture on the Decision to Become a Member of the Dance Studio aims to analyze the influence of X1 and X2 on Y" has a population of 329 people and a sample of 100 people. By using a quantitative approach and descriptive analysis, in the variable X1 the dimension of value expression obtained the highest average score with a percentage of 51.82%, in the X2 variable the highest was the view of 59.50%, in the variable Y the highest was personality at 25.57%. Whereas in the verification analysis, the relationship between X1 and X2 is 0.426 which means that the correlation is moderate. For 5% error the two-tailed test and df = n - 3 = 97 is 1.66071. Because the t statistic> from t table (4.328> 1.66071), Ho is rejected. The significant column number is 0.000 or the probability is far below 0.05. So it means that X1 and X2 partially have a significant effect on Y.From the ANOVA test or F test, it is found that the F count is 19.714 with a significant level indicating a value of 0.000 which means less than 5%, it can be concluded that X1 and X2 are Simultaneously affects Decision Y.
Keywords : Reference Group, Culture, Purchasing Decision
PENGARUH SEKTOR PARIWISATA TERHADAP PENDAPATAN ASLI DAERAH DI EKS KARESIDENAN MADIUN
Authors: Efrintya Elnin , Muchtolifah Muchtolifah , Sishadiyati Sishadiyati 
Published: September 2021

Abstract
Tourism is one of the sector that can increase regional income in the service industry. The purpose of this study was to determine the effect of the number of hotels, tourist attractions, and tourist visits on local revenue in the Madiun Residency. This study uses panel data with time series data for the 2015-2019 period and with cross-sectional data for six districts/cities obtained from the BPS website for each district. The type of survey is a quantitative survey using panel data regression analysis processed with the Eviews 10 tool. The results show that simultaneously it is found the number of hotels, the number of tourist destinations, and the number of tourist visits have a significant effect on the local economy with a value of sig 0.0000078 <0.05. Partially, the results show that the number of hotels has a significant effect on local revenue with a value of 0.0056 <0.05 and the number of tourist visits has no significant effect on income native to the area with value 0.2741 > 0.05.