bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effects of polymer plugging mechanism of liquid production decrease and improvement by the cross-linked gel performance
Authors: Ma Kuiqian , Zene Mahamat Tahir Abdramane Mahamat , Baozhen Li , Jiang Ruizhong , Fan Haijun , Cui Yongzheng , Wei Liu Xiu 
Published: October 2021

AbstractPolymer flooding, as the most successful and well-known chemical EOR method was broadly applied around the world. Mostly, contrasted with Waterflooding, the production rate decrease during polymer flooding is smaller based on field application. Nevertheless, the production liquid rate decreased critically in the middle phase to late phase due to plugging, which could lead the way to poor flooding performance and fewer cumulative oil. In this work, first, we approached the affecting polymer plugging mechanism model on liquid production decrease to investigate the parameters such as; solid-phase concentration (SOLIDMIN), reacting frequency factor (FREQFAC) and others affecting components are all investigated consecutively. Secondly the model approached by cross-linked gel for the improvement of production liquid rate. The physical work was designed by a physical model, and then the polymer adsorption that generating blockage emerging in permeability diminish assessed by a mathematical model. The outcomes specify that the existence of this debris, excessive assemblage of solid-phase and the excessive reactant frequency factor has major mechanical and physical parameters effects on the reservoir throughout polymer flooding. Polymer flood model base case liquid ratio loss is 11.15 m3/day between the years 2014-08-01 to 2020-03-04. Comparing with the polymer flood model case 1, liquid ratio loss ranging to 1.97 m3/day between the years 2014-08-02 to 2020-03-03. While the oil ratio loss of the polymer flood base case model between the years 2015-07-08 to 2020-03-04 attained 12.4 m3/day contrasting with the polymer flood model case 1 oil ratio increase to 0.37 m3/day between the years 2014-08-04 to 2019-04-02. The cross-linked gel model base case liquid ratio loss is 2.09 m3/day between the years 2015-01-02 to 2020-02-03, while the oil ratio lost reached 9.15 m3/day between the years 2015-09-01 to 2020-02-03. Contrasting with the cross-linked gel model case 2 liquid ratio recovered from the loss and attained 25.43 m3/day in the year 2020-12-01, while the oil ratio is reached 15.22 m3/day in the year 2020-12-01. Polymer flood model examined through cross-linked gel model performed reliable outcomes by taking out the plugging, which also occasioned the reservoir production rate to decrease. With the application of cross-linked gel the affected parameters and the production rate have achieved an improvement.
Low defect and high electrical conductivity of graphene through plasma graphene healing treatment monitored with in situ optical emission spectroscopy
Authors: Salehi Mohammad , Bastani Parnia , Jamilpanah Loghman , Madani Abbas , Mohseni Seyed Majid , Shokri Babak 
Published: October 2021

AbstractFundamental studies on graphene (Gr) and its real device applications have been affected by unavoidable defects and impurities which are usually present in synthesized Gr. Therefore, post treatment methods on Gr have been an important subject of research followed by the community. Here, we demonstrate a post-treatment of cm-sized CVD-grown graphene in a Radio Frequency-generated low-pressure plasma of methane and hydrogen to remove oxygen functional groups and heal the structural defects. The optimum plasma treatment parameters, such as pressure, plasma power, and the ratio of the gases, are optimized using in-situ optical emission spectroscopy. This way we present an optimal healing condition monitored with in situ OES. A twofold increase in the conductivity of plasma-treated Gr samples was obtained. Plasma treatment conditions give insights into the possible underlying mechanisms, and the method presents an effective way to obtain improved Gr quality.
Reliability and usefulness of the single leg heel raise balance test in patients with chronic ankle instability
Authors: Lee Jin Hyuck , Jung Hae Woon , Jung Taek Sung , Jang Woo Young 
Published: October 2021

AbstractWe aimed to analyze the differences in static (including conventional and modified [single-leg heel-raise balance]) and dynamic postural stability and muscle endurance between patients with chronic ankle instability (CAI) and healthy controls, and to determine the reliability and usefulness of the single-leg heel-raise balance test in patients with CAI. In total, 26 patients with CAI and 26 healthy controls were enrolled. Postural stability was assessed using a postural stabilometry system. Muscle endurance was measured in dorsiflexion and plantarflexion using an isokinetic device. Modified static postural stability (P < 0.001) and dynamic postural stability (P < 0.001) were significantly poorer in the affected ankles of patients with CAI than in the controls. Plantarflexion endurance was significantly lower in the affected ankles of the patients with CAI than in the controls (P = 0.023). Modified static postural stability significantly correlated with plantarflexion endurance in both groups (CAI group: r = − 0.470, P = 0.015; healthy controls group: r = − 0.413, P = 0.036). Plantarflexion endurance was a significant risk factor for modified static postural stability in both the CAI group (R2 = 0.221, P = 0.015) and healthy controls (R2 = 0.170, P = 0.036). Given the reliability of the modified static postural stability test, clinicians and therapists should consider using it to assess improvements in postural stability and muscle endurance in patients with CAI before and after rehabilitation.
Influence of dietary intervention on microvascular endothelial function in coronary patients and atherothrombotic risk of recurrence
Authors: Millan-Orge Marta , Torres-Peña Jose D. , Arenas-Larriva Antonio , Quintana-Navarro Gracia M. , Peña-Orihuela Patricia , Alcala-Diaz Juan F. , Luque Raul M. , Rodriguez-Cantalejo Fernando , Katsiki Niki , Lopez-Miranda Jose , Perez-Martinez Pablo , Delgado-Lista Javier 
Published: October 2021

AbstractEndothelial dysfunction is a key player in both the onset and development of atherosclerosis. No study has examined whether healthy dietary patterns can improve microvascular endothelial function in patients with coronary heart disease (CHD) in the long-term and whether this relationship can affect patient’s risk of CHD recurrence. In the CORDIOPREV study, a randomized, double-blind, controlled trial, dietary intervention with either the Mediterranean diet or a low-fat diet was implemented in 1,002 CHD patients. A laser-doppler flowmetry was performed at baseline and after 6 years of follow up in 664 patients, evaluating the effects of this dietary intervention on microvascular basal flow and reactive hyperaemia area, as well as on the risk of CHD recurrence, based on the TRS2P risk score. Basal flow (97.78 ± 2.79 vs. 179.31 ± 5.06 arbitrary perfusion units, 83.38% increase, p < 0.001) and reactive hyperaemia area (4233.3 ± 127.73 vs. 9695.9 ± 205.23 arbitrary perfusion units per time, 129.04% increase, p < 0.001) improved after the dietary intervention in the cohort, without finding differences due to the diet (p > 0.05 for the diet-effect). When patients were stratified to low, moderate or high-risk of recurrence, basal flow was similarly increased in all three groups. However, reactive hyperaemia area was improved to a greater extent in patients at the low-risk group compared with those at moderate or high-risk. No differences were observed between diets. Healthy dietary patterns can improve microvascular endothelial function and this improvement persists in the long-term. Patients with a low-risk of CHD recurrence show a greater improvement in reactive vasodilation to ischemia than patients in the moderate or high-risk groups.
Ventricular longitudinal shortening is an independent predictor of death in heart failure patients with reduced ejection fraction
Authors: Berg J. , Jablonowski R. , Mohammad M. , Solem K. , Borgquist R. , Ostenfeld E. , Arheden H. , Carlsson M. 
Published: October 2021

AbstractReduced ventricular longitudinal shortening measured by atrioventricular plane displacement (AVPD) and global longitudinal strain (GLS) are prognostic markers in heart disease. This study aims to determine if AVPD and GLS with cardiovascular magnetic resonance (CMR) are independent predictors of cardiovascular (CV) and all-cause death also in heart failure with reduced ejection fraction (HFrEF). Patients (n = 287) were examined with CMR and AVPD, GLS, ventricular volumes, myocardial fibrosis/scar were measured. Follow-up was 5 years with cause of death retrieved from a national registry. Forty CV and 60 all-cause deaths occurred and CV non-survivors had a lower AVPD (6.4 ± 2.0 vs 8.0 ± 2.4 mm, p < 0.001) and worse GLS (− 6.1 ± 2.2 vs − 7.7 ± 3.1%, p = 0.001). Kaplan–Meier analyses displayed increased survival for patients in the highest AVPD- and GLS-tertiles vs. the lowest tertiles (AVPD: p = 0.001, GLS: p = 0.013). AVPD and GLS showed in univariate analysis a hazard ratio (HR) of 1.30 (per-mm-decrease) and 1.19 (per-%-decrease) for CV death. Mean AVPD and GLS were independent predictors of all-cause death (HR = 1.24 per-mm-decrease and 1.15 per-%-decrease), but only AVPD showed incremental value over age, sex, body-mass-index, EF, etiology and fibrosis/scar for CV death (HR = 1.33 per-mm-decrease, p < 0.001). Ventricular longitudinal shortening remains independently prognostic for death in HFrEF even after adjusting for well-known clinical risk factors.
Viability fingerprint of glioblastoma cell lines: roles of mitotic, proliferative, and epigenetic targets
Authors: Lavogina Darja , Laasfeld Tõnis , Vardja Markus , Lust Helen , Jaal Jana 
Published: October 2021

AbstractDespite the use of multimodal treatment combinations, the prognosis of glioblastoma (GB) is still poor. To prevent rapid tumor recurrence, targeted strategies for the treatment of GB are widely sought. Here, we compared the efficacy of focused modulation of a set of signaling pathways in two GB cell lines, U-251 MG and T98-G, using a panel of thirteen compounds targeting cell cycle progression, proliferation, epigenetic modifications, and DNA repair mechanism. In parallel, we tested combinations of these compounds with temozolomide and lomustine, the standard chemotherapy agents used in GB treatment. Two major trends were found: within individual compounds, the lowest IC50 values were exhibited by the Aurora kinase inhibitors, whereas in the case of mixtures, the addition of DNA methyltransferase 1 inhibitor azacytidine to lomustine proved the most beneficial. The efficacy of cell cycle-targeting compounds was further augmented by combination with radiation therapy using two different treatment regimes. The potency of azacytidine and lomustine mixtures was validated using a unique assay pipeline that utilizes automated imaging and machine learning-based data analysis algorithm for assessment of cell number and DNA damage extent. Based on our results, the combination of azacytidine and lomustine should be tested in GB clinical trials.
Gene.iobio: an interactive web tool for versatile, clinically-driven variant interrogation and prioritization
Authors: Di Sera Tonya , Velinder Matt , Ward Alistair , Qiao Yi , Georges Stephanie , Miller Chase , Pitman Anders , Richards Will , Ekawade Aditya , Viskochil David , Carey John C. , Pace Laura , Bale Jim , Clardy Stacey L. , Andrews Ashley , Botto Lorenzo , Marth Gabor 
Published: October 2021

AbstractWith increasing utilization of comprehensive genomic data to guide clinical care, anticipated to become the standard of care in many clinical settings, the practice of diagnostic medicine is undergoing a notable shift. However, the move from single-gene or panel-based genetic testing to exome and genome sequencing has not been matched by the development of tools to enable diagnosticians to interpret increasingly complex or uncertain genomic findings. Here, we presentgene.iobio, a real-time, intuitive and interactive web application for clinically-driven variant interrogation and prioritization. We showgene.iobiois a novel and effective approach that significantly improves upon and reimagines existing methods. In a radical departure from existing methods that present variants and genomic data in text and table formats,gene.iobioprovides an interactive, intuitive and visually-driven analysis environment. We demonstrate that adoption ofgene.iobioin clinical and research settings empowers clinical care providers to interact directly with patient genomic data both for establishing clinical diagnoses and informing patient care, using sophisticated genomic analyses that previously were only accessible via complex command line tools.
Slower adaptation of control strategies in individuals with high impulsive tendencies
Authors: Grisetto Fanny , Delevoye-Turrell Yvonne N. , Roger Clémence 
Published: October 2021

AbstractFlexible use of reactive and proactive control according to environmental demands is the key to adaptive behavior. In this study, forty-eight adults performed ten blocks of an AX-CPT task to reveal the strength of proactive control by the calculation of the proactive behavioral index (PBI). They also filled out the UPPS questionnaire to assess their impulsiveness. The median-split method based on the global UPPS score distribution was used to categorize participants as having high (HI) or low (LI) impulsiveness traits. The analyses revealed that the PBI was negatively correlated with the UPPS scores, suggesting that the higher is the impulsiveness, the weaker the dominance of proactive control processes. We showed, at an individual level, that the PBI increased across blocks and suggested that this effect was due to a smaller decrease in reactive control processes. Notably, the PBI increase was slower in the HI group than in the LI group. Moreover, participants who did not adapt to task demands were all characterized as high impulsive. Overall, the current study demonstrates that (1) impulsiveness is associated with less dominant proactive control due to (2) slower adaptation to task demands (3) driven by a stronger reliance on reactive processes. These findings are discussed in regards to pathological populations.
Quantitative evaluation of posture control in rats with inferior olive lesions
Authors: Funato Tetsuro , Sato Yota , Sato Yamato , Fujiki Soichiro , Aoi Shinya , Tsuchiya Kazuo , Yanagihara Dai 
Published: October 2021

AbstractImpairment of inferior olivary neurons (IONs) affects whole-body movements and results in abnormal gait and posture. Because IONs are activated by unpredicted motion rather than regular body movements, the postural dysfunction caused by ION lesions is expected to involve factors other than simple loss of feedback control. In this study, we measured the postural movements of rats with pharmacological ION lesions (IO rats) trained to stand on their hindlimbs. The coordination of body segments as well as the distribution and frequency characteristics of center of mass (COM) motion were analyzed. We determined that the lesion altered the peak properties of the power spectrum density of the COM, whereas changes in coordination and COM distribution were minor. To investigate how the observed properties reflected changes in the control system, we constructed a mathematical model of the standing rats and quantitatively identified the control system. We found an increase in linear proportional control and a decrease in differential and nonlinear control in IO rats compared with intact rats. The dystonia-like changes in body stiffness explain the nature of the linear proportional and differential control, and a disorder in the internal model is one possible cause of the decrease in nonlinear control.
Genomic prediction for testes weight of the tiger pufferfish, Takifugu rubripes, using medium to low density SNPs
Authors: Hosoya Sho , Yoshikawa Sota , Sato Mana , Kikuchi Kiyoshi 
Published: October 2021

AbstractAquaculture production is expected to increase with the help of genomic selection (GS). The possibility of performing GS using only a small number of SNPs has been examined in order to reduce genotyping costs; however, the practicality of this approach is still unclear. Here, we tested whether the effects of reducing the number of SNPs impaired the prediction accuracy of GS for standard length, body weight, and testes weight in the tiger pufferfish (Takifugu rubripes). High values for predictive ability (0.563–0.606) were obtained with 4000 SNPs for all traits under a genomic best linear unbiased predictor (GBLUP) model. These values were still within an acceptable range with 1200 SNPs (0.554–0.588). However, predictive abilities and prediction accuracies deteriorated using less than 1200 SNPs largely due to the reduced power in accurately estimating the genetic relationship among individuals; family structure could still be resolved with as few as 400 SNPs. This suggests that the SNPs informative for estimation of genetic relatedness among individuals differ from those for inference of family structure, and that non-random SNP selection based on the effects on family structure (e.g., site-FST, principal components, or random forest) is unlikely to increase the prediction accuracy for these traits.
Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
Authors: Poblocka Marta , Bassey Akang Leonard , Smith Victoria M. , Falcicchio Marta , Manso Ana Sousa , Althubiti Mohammad , Sheng XiaoBo , Kyle Andrew , Barber Ruth , Frigerio Mark , Macip Salvador 
Published: October 2021

AbstractA wide range of diseases have been shown to be influenced by the accumulation of senescent cells, from fibrosis to diabetes, cancer, Alzheimer’s and other age-related pathologies. Consistent with this, clearance of senescent cells can prolong healthspan and lifespan in in vivo models. This provided a rationale for developing a new class of drugs, called senolytics, designed to selectively eliminate senescent cells in human tissues. The senolytics tested so far lack specificity and have significant off-target effects, suggesting that a targeted approach could be more clinically relevant. Here, we propose to use an extracellular epitope of B2M, a recently identified membrane marker of senescence, as a target for the specific delivery of toxic drugs into senescent cells. We show that an antibody–drug conjugate (ADC) against B2M clears senescent cells by releasing duocarmycin into them, while an isotype control ADC was not toxic for these cells. This effect was dependent on p53 expression and therefore more evident in stress-induced senescence. Non-senescent cells were not affected by either antibody, confirming the specificity of the treatment. Our results provide a proof-of-principle assessment of a novel approach for the specific elimination of senescent cells using a second generation targeted senolytic against proteins of their surfaceome, which could have clinical applications in pathological ageing and associated diseases.
Nitric oxide mediates activity-dependent change to synaptic excitation during a critical period in Drosophila
Authors: Giachello Carlo N. G. , Fan Yuen Ngan , Landgraf Matthias , Baines Richard A. 
Published: October 2021

AbstractThe emergence of coordinated network function during nervous system development is often associated with critical periods. These phases are sensitive to activity perturbations during, but not outside, of the critical period, that can lead to permanently altered network function for reasons that are not well understood. In particular, the mechanisms that transduce neuronal activity to regulating changes in neuronal physiology or structure are not known. Here, we take advantage of a recently identified invertebrate model for studying critical periods, the Drosophila larval locomotor system. Manipulation of neuronal activity during this critical period is sufficient to increase synaptic excitation and to permanently leave the locomotor network prone to induced seizures. Using genetics and pharmacological manipulations, we identify nitric oxide (NO)-signaling as a key mediator of activity. Transiently increasing or decreasing NO-signaling during the critical period mimics the effects of activity manipulations, causing the same lasting changes in synaptic transmission and susceptibility to seizure induction. Moreover, the effects of increased activity on the developing network are suppressed by concomitant reduction in NO-signaling and enhanced by additional NO-signaling. These data identify NO signaling as a downstream effector, providing new mechanistic insight into how activity during a critical period tunes a developing network.
Mask wearing increases eye involvement during smiling: a facial EMG study
Authors: Okazaki Shuntaro , Yamanami Haruna , Nakagawa Fumika , Takuwa Nozomi , Kawabata Duncan Keith James 
Published: October 2021

AbstractThe use of face masks has become ubiquitous. Although mask wearing is a convenient way to reduce the spread of disease, it is important to know how the mask affects our communication via facial expression. For example, when we are wearing the mask and meet a friend, are our facial expressions different compared to when we are not? We investigated the effect of face mask wearing on facial expression, including the area around the eyes. We measured surface electromyography from zygomaticus major, orbicularis oculi, and depressor anguli oris muscles, when people smiled and talked with or without a mask. Only the actions of the orbicularis oculi were facilitated by wearing the mask. We thus concluded that mask wearing may increase the recruitment of the eyes during smiling. In other words, we can express joy and happiness even when wearing a face mask.
Ten years of pluviometric analyses in Italy for civil protection purposes
Authors: Del Soldato Matteo , Rosi Ascanio , Delli Passeri Luca , Cacciamani Carlo , Catani Filippo , Casagli Nicola 
Published: October 2021

AbstractThe concept of climate change has grown in recent decades, influencing the scientific community to conduct research on meteorological parameters and their variabilities. Research on global warming, as well as on its possible economic and environmental consequences, has spread over the last 20 years. Diffused changes in trends have been stated by several authors throughout the world, with different developments observed depending on the continent. Following a period of approximately 40 days of almost continuous rain that occurred from October to November 2019 across the Italian territory and caused several hazards (e.g., floods and landslides), a relevant question for decision-makers and civil protection actors emerged regarding the relative frequencies of given rainfall events in the Warning Hazard Zones (WHZs) of Italy. The derived products of this work could answer this question for both weather and hydrogeological operators thanks to the frequency and spatio-temporal distribution analyses conducted on 10-year daily rainfall data over the entire Italian territory. This work aspires to be an additional tool used to analyse events that have occurred, providing further information for a better understanding of the probability of occurrence and distribution of future events.