bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rancangan Model Digitalisasi Pasar Tradisional Pasar Rare Angon Di Desa Gunaksa
Authors: Wiguna I Kadek Arta , Ariana Komang Agus 
Published: September 2021

Abstract: The increasing cases of covid-19 have an impact on the economy in Indonesia, especially on micro, small and medium enterprises (MSMEs). local communities who during this pandemic experienced a decline in income. Shoppers are starting to rarely come to the market and shop in person because of their fear of contracting Covid-19 and avoiding crowds that have been advised by the government. The digitalization of traditional people's markets is needed to improve the economy and reduce the spread of the covid-19 virus. The results of interviews with traders show the lack of sales at Rare Angon Market because few people know about the market. the method used by distributing questionnaires to find out in detail the existing problems. From these problems, a solution is needed to bridge between traders and buyers, this solution is in the form of digitizing the Rare Angon market by developing an application called "Rare Angon App" where the application is used for buying and selling interactions by traders and buyers. So that sales in the Rare Angon market can increase.Keywords: E-commerce; traditional market; information technology Abstrak: Meningkatnya kasus covid-19 berdampak pada perekonomian di Indonesia terutama pada usaha mikro kecil meneengah (UMKM) hal ini dapat dilihat dari pasar-pasar rakyat di Bali yaitu Pasar Rare Angon yang berlokasi di desa Gunaksa, kecamatan Dawan kabupaten Klungkung dengan mayoritas pedangannya adalah warga didaerah setempat yang dimasa pandemi ini mengalami penurunan pendapatan. Para pembeli mulai jarang datang ke pasar dan berlanja secara langsung karena ketakutan mereka tertular covid-19 dan menghindari kerumunan yang sudah dihimbau oleh pemerintah. Diperlukannya digitalisasi pasar rakyat yang bersifat tradisional untuk meningkatkan perekonomian dan mengurangi penyebaran virus covid-19. Hasil wawancara dengan pedagang menunjukkan minimnya penjualan di Pasar Rare Angon karena masih sedikit masyarakat yang tau pasar tersebut. metode yang digunakan dengan penyebaran kuesioner untuk mengetahui secara detail permasalahan yang ada. Dari permasalahan tersebut diperlukannya solusi untuk untuk menjembatanni antara pedagang dan pembeli, solusi ini berupa digitalisasi pasar Rare Angon ini dengan membuatkan aplikasi yang diberi nama “Rare Angon App” dimana aplikasi tersebut digunakan untuk interakasi jual beli oleh pedagang dan pembeli. Sehingga penjualan dipasar Rare Angon bisa mengalami peningkatan.Kata kunci: E-commerce; pasar tradisional; teknologi informasi
Pengaruh Kepuasan Kerja dan Perencanaan Pemeriksaan Pajak Terhadap Kinerja Pemeriksa Pajak di KPP Kota Palembang
Authors: Panjaitan Delfi , Lesmana Desy , Maimunah Mutiara 
Published: September 2021

This study aims to determine the effect of job satisfaction and tax audit planning on the performance of tax auditors in Palembang. The population of this study was all ASNs within the Directorate General of Taxation who served as Examiners in the Regional Office of the Directorate General of Taxes of North Sumatra. The sample in this study was the examiner at the KPP in the city of Palembang. Data is collected by distributing questionnaires. The research analysis method used is multiple linear regression. The results showed that job satisfaction has a positive effect on the performance of tax auditors, while tax audit planning does not affect the performance of tax auditors.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh kepuasan kerja dan perencanaan pemeriksaan pajak terhadap kinerja pemeriksa pajak di KPP Kota Palembang. Populasi penelitian ini adalah seluruh ASN dilingkungan Direktorat Jenderal Pajak yang bertugas sebagai Pemeriksa pada Kanwil DJP Sumsel Babel. Sampel pada penelitian ini adalah pemeriksa di KPP di Kota Palembang. Data dikumpulkan dengan pembagian kuisoner. Metode analisis penelitian yang digunakan adalah regresi linier berganda. Hasil penelitian menunjukkan bahwa kepuasan kerja berpengaruh positip terrhadap kinerja pemeriksa pajak, sementara perencanaan pemeriksaan pajak tidak mempengaruhi kinerja pemeriksa pajak.
Kata Kunci: Pemeriksa Pajak, Kepuasan Kerja, Perencanaan Pemeriksaan, dan Kinerja.
Analisis Kinerja Perusahaan Sebelum dan Setelah Melakukan Merger dan Akuisisi
Authors: Wulandari Try 
Published: September 2021

Mergers and acquisitions are an alternative that can be taken by companies that are experiencing bankruptcy or for companies that want to expand their companies. There are many examples of successful mergers and companies that are even bigger than before. This has made mergers and acquisitions a concern in recent years, both in Indonesia and abroad. This research was conducted to test whether mergers conducted by several companies in 2015 can change company performance for the better or not, bearing in mind that not all mergers end beautifully and as expected. From the ten companies sampled, normality tests and paired sample t-tests were conducted using SPSS 24 software. The results obtained are differences in company performance before and after conducting mergers and acquisitions. This shows from the significance value < 0.05 also the results of the comparison of the value of t-count and t-table where the value of t-count > t-table. These findings are also supported by the results of the pair correlation test which shows that there is a relationship between each of the company's performance variables before and after mergers and acquisitions.

Abstrak
Merger dan akuisisi dapat menjadi alternative bagi perusahaan untuk mencegah kebangkrutan atau untuk mengembangkan perusahaannya. Ada banyak contoh perusahaan yang melakukan merger dan berhasil menjadikan perusahaannya lebih besar dari sebelumnya. Hal ini mendorong merger dan akuisisi menjadi perhatian bagi perusahaan dalam beberapa tahun terakhir, baik di Indonesia maupun di luar negeri. Penelitian bertujuan untuk menguji apakah merger yang dilakukan oleh sepuluh (10) perusahaan pada tahun 2015 merupakan keputusan yang tepat dan terbukti mampu meningkatkan nilai perusahaan. Bagaimanapun, ada beberapa perusahaan yang gagal dalam melakukan merger. Pengujian tes normalitas dan uji beda yang digunakan dalam penelitian ini diproses melalui perangkat lunak, SPSS 24. Hasil yang didapat adalah nilai signifikan < 0.05 dan nilai t-hitung > nilai t-tabel. Uji korelasi juga dilakukan untuk memperkuat hasil temuan yang menyimpulkan bahwa setelah melakukan merger dan akuisisi, performa perusahaan meningkat dan ada hubungan antar nilai perusahaan sebelum dan setelah melakukan merger. Maka, dapat disimpulkan bahwa melakukan merger dan akusisi merupakan langkah yang tepat untuk dilakukan.
Kata kunci: Merger, Akuisisi, Current Ratio, Return on Equity, Debt to Asset Ratio
Arbeidsinnkludering som en vei til varig arbeidslivstilknytning og et verdig voksenliv: Hvordan metoder for arbeidsinnkludering kan brukes i opplæringen av lærekandidater
Authors: Dyrnes Eva Martinsen , Sträng Dan Roger 
Published: September 2021

The labour market in many European countries is changing and for many young people it leads to challenges in gaining a lasting connection to working life.
School dropout and deficiencies in their education lead to challenges for many young people on the road to adulthood. Students who find it difficult to complete a vocational education in upper secondary school, now have the opportunity to be training candidates in a practically oriented education with a limited number of competence goals.
Work inclusion means that the individual's ability to work will be examined in various ways to increase the possibility of permanent work. However, work inclusion is a complex phenomenon, where several actors may be involved and where the goals and progress plan will vary. This is costly and stressful for both the individual and the society. Working life is a central learning arena within upper secondary education, and there will be a need to facilitate participation in this arena also for students with a need for adapted education.
Biallelic Mutations in ACACA Cause a Disruption in Lipid Homeostasis That Is Associated With Global Developmental Delay, Microcephaly, and Dysmorphic Facial Features
Authors: Lou Xiaoting , Zhou Xiyue , Li Haiyan , Lu Xiangpeng , Bao Xinzhu , Yang Kaiqiang , Liao Xin , Chen Hanxiao , Fang Hezhi , Yang Yanling , Lyu Jianxin , Zheng Hong 
Published: September 2021

ObjectiveWe proposed that the deficit of ACC1 is the cause of patient symptoms including global developmental delay, microcephaly, hypotonia, and dysmorphic facial features. We evaluated the possible disease-causing role of the ACACA gene in developmental delay and investigated the pathogenesis of ACC1 deficiency.MethodsA patient who presented with global developmental delay with unknown cause was recruited. Detailed medical records were collected and reviewed. Whole exome sequencing found two variants of ACACA with unknown significance. ACC1 mRNA expression level, protein expression level, and enzyme activity level were detected in patient-derived cells. Lipidomic analysis, and in vitro functional studies including cell proliferation, apoptosis, and the migratory ability of patient-derived cells were evaluated to investigate the possible pathogenic mechanism of ACC1 deficiency. RNAi-induced ACC1 deficiency fibroblasts were established to assess the causative role of ACC1 deficit in cell migratory disability in patient-derived cells. Palmitate supplementation assays were performed to assess the effect of palmitic acid on ACC1 deficiency-induced cell motility deficit.ResultsThe patient presented with global developmental delay, microcephaly, hypotonia, and dysmorphic facial features. A decreased level of ACC1 and ACC1 enzyme activity were detected in patient-derived lymphocytes. Lipidomic profiles revealed a disruption in the lipid homeostasis of the patient-derived cell lines. In vitro functional studies revealed a deficit of cell motility in patient-derived cells and the phenotype was further recapitulated in ACC1-knockdown (KD) fibroblasts. The cell motility deficit in both patient-derived cells and ACC1-KD were attenuated by palmitate.ConclusionWe report an individual with biallelic mutations in ACACA, presenting global development delay. In vitro studies revealed a disruption of lipid homeostasis in patient-derived lymphocytes, further inducing the deficit of cell motility capacity and that the deficiency could be partly attenuated by palmitate.
Identification of a Novel Prognostic Gene Signature From the Immune Cell Infiltration Landscape of Osteosarcoma
Authors: Fan Lei , Ru Jingtao , Liu Tao , Ma Chao 
Published: September 2021

Background: The tumor microenvironment (TME) mainly comprises tumor cells and tumor-infiltrating immune cells mixed with stromal components. Latestresearch hasdisplayed that tumor immune cell infiltration (ICI) is associated with the clinical outcome of patients with osteosarcoma (OS). This work aimed to build a gene signature according to ICI in OS for predicting patient outcomes.Methods: The TARGET-OS dataset was used for model training, while the GSE21257 dataset was taken forvalidation. Unsupervised clustering was performed on the training cohort based on the ICI profiles. The Kaplan–Meier estimator and univariate Cox proportional hazards models were used to identify the differentially expressed genes between clusters to preliminarily screen for potential prognostic genes. We incorporated these potential prognostic genes into a LASSO regression analysis and produced a gene signature, which was next assessed with the Kaplan–Meier estimator, Cox proportional hazards models, ROC curves, IAUC, and IBS in the training and validation cohorts. In addition, we compared our signature to previous models. GSEAswere deployed to further study the functional mechanism of the signature. We conducted an analysis of 22 TICsfor identifying the role of TICs in the gene signature’s prognosis ability.Results: Data from the training cohort were used to generate a nine-gene signature. The Kaplan–Meier estimator, Cox proportional hazards models, ROC curves, IAUC, and IBS validated the signature’s capacity and independence in predicting the outcomes of OS patients in the validation cohort. A comparison with previous studies confirmed the superiority of our signature regarding its prognostic ability. Annotation analysis revealed the mechanism related to the gene signature specifically. The immune-infiltration analysis uncoveredkey roles for activated mast cells in the prognosis of OS.Conclusion: We identified a robust nine-gene signature (ZFP90, UHRF2, SELPLG, PLD3, PLCB4, IFNGR1, DLEU2, ATP6V1E1, and ANXA5) that can predict OS outcome precisely and is strongly linked to activated mast cells.
Insulin Resistance Adversely Affect IVF Outcomes in Lean Women Without PCOS
Authors: Wang Haoyu , Zhang Yu , Fang Xuhui , Kwak-Kim Joanne , Wu Li 
Published: September 2021

ObjectiveTo investigate the effects of insulin resistance (IR) on IVF outcomes and a potential underlying mechanism in lean women without PCOS.DesignA prospective cohort study at the University Clinic.SettingIVF center at the University setting.PatientsA total of 155 lean women (body mass index &lt;25) without PCOS undergoing IVF cycle.InterventionPatients were allocated to IR and non-IR groups based on HOMA-M120.Main Outcome Measure(s)IVF outcomes, including egg quality, the percentage of mature oocytes, fertilization rate, blastocyst formation rate, advanced embryo rate, and cumulative live birth rate were investigated. Auto-immune parameters, peripheral blood immunophenotypes, thyroid hormone, homocysteine, and 25-OH-vitamin D3 (25-OH-VD3) levels were analyzed.ResultsThe percentage of mature oocytes and blastocyst formation rate were significantly lower in the IR group as compared with those of the non-IR group (p&lt;0.05, respectively). The proportion of peripheral blood CD19+ B cells was significantly higher in the IR group than those of the non-IR group (p&lt;0.05). Homocysteine, 25-OH-VD3, and auto-immune parameters were the same between the two groups.ConclusionIn lean infertile women without PCOS, IR is associated with the decreased percentage of mature eggs and poor embryo quality in which B cell immunity may play a role.
A Convolutional Neural Network Deep Learning Model Trained on CD Ulcers Images Accurately Identifies NSAID Ulcers
Authors: Klang Eyal , Kopylov Uri , Mortensen Brynjulf , Damholt Anders , Soffer Shelly , Barash Yiftach , Konen Eli , Grinman Ana , Yehuda Reuma Margalit , Buckley Martin , Shanahan Fergus , Eliakim Rami , Ben-Horin Shomron 
Published: September 2021

Background and Study Aims: Deep learning (DL) for video capsule endoscopy (VCE) is an emerging research field. It has shown high accuracy for the detection of Crohn's disease (CD) ulcers. Non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used medications. In the small bowel, NSAIDs may cause a variety of gastrointestinal adverse events including NSAID-induced ulcers. These ulcers are the most important differential diagnosis for small bowel ulcers in patients evaluated for suspected CD. We evaluated a DL network that was trained using CD VCE ulcer images and evaluated its performance for NSAID ulcers.Patients and Methods: The network was trained using CD ulcers and normal mucosa from a large image bank created from VCE of diagnosed CD patients. NSAIDs-induced enteropathy images were extracted from the prospective Bifidobacterium breve (BIf95) trial dataset. All images were acquired from studies performed using PillCam SBIII. The area under the receiver operating curve (AUC) was used as a metric. We compared the network's AUC for detecting NSAID ulcers to that of detecting CD ulcers.Results: Overall, the CD training dataset included 17,640 CE images. The NSAIDs testing dataset included 1,605 CE images. The DL network exhibited an AUC of 0.97 (95% CI 0.97–0.98) for identifying images with NSAID mucosal ulcers. The diagnostic accuracy was similar to that obtained for CD related ulcers (AUC 0.94–0.99).Conclusions: A network trained on VCE CD ulcers similarly identified NSAID findings. As deep learning is transforming gastrointestinal endoscopy, this result should be taken into consideration in the future design and analysis of VCE deep learning applications.
Stress Granules Modulate SYK to Cause Tau-Associated Neurocognitive Deterioration in 5XFAD Mouse After Anesthesia and Surgery
Authors: Shen Yang , Zhang Tong , Zhang Yinglin , Wang Yinuo , Yao Junyan 
Published: September 2021

BackgroundAlzheimer’s disease (AD) is the most common type of dementia. However, no curative therapy has been found effective to slow down the process of AD. It is reported that anesthesia and surgery will induce neurocognitive deterioration in AD, but the mechanism is not quite clear. In this study, we aim to compare the cognitive impairment between 5XFAD transgenic (Tg) mice and its littermate (LM) after isoflurane anesthesia and surgery to clarify the specific impacts of anesthesia and surgery on individuals with AD and to explore the mechanisms.MethodsWe performed abdominal surgery in cognitively impaired, 4-month-old female 5XFAD mice and LM control mice. Isoflurane anesthesia (1.4%) was induced and maintained over 2 h. Open field and fear conditioning tests were conducted on 1, 3 and 7 days after anesthesia and surgery. The total distance, velocity and freezing time were the major outcomes. P-tau (AT8), tau oligomers (T22), stress granules (SGs), the SYK tyrosine kinase and p-SYK in the hippocampus at postoperative day 1 were evaluated by Western Blot assays. The colocalization of SGs, SYK, p-SYK, and neurons in the hippocampus section was assessed using qualitative immunofluorescence.ResultsIn the open field test, no difference between the distance moved and the velocity of LM mice and 5XFAD Tg mice were found on day 1 after anesthesia and surgery. 5XFAD Tg mice exhibited reduced freezing time of fear conditioning context test on postoperative day 3, but not on day 7; the LM mice showed no changes in FCTs. Furthermore, p-tau, tau oligomers, SGs, SYK and p-SYK were evident in the hippocampus region of 5XFAD Tg mice on a postoperative day 1. In addition, SGs, SYK, p-SYK were colocalized with hippocampus neurons, as shown by immunofluorescence.ConclusionThis study demonstrates that anesthesia and surgery may induce tau-associated neurocognitive deterioration in individuals with AD. The mechanism under it may be associated with SGs and the tyrosine kinase, SYK. After anesthesia and surgery, in 5XFAD Tg mice, SGs were formed and SYK was phosphorylated, which may contribute to the phosphorylation of tau protein. This study provided hints that individuals with AD may be more vulnerable to anesthesia and surgery.
Remote Ischemic Conditioning May Improve Disability and Cognition After Acute Ischemic Stroke: A Pilot Randomized Clinical Trial
Authors: Poalelungi Alina , Tulbă Delia , Turiac Elena , Stoian Diana , Popescu Bogdan Ovidiu 
Published: September 2021

Background and Aim: Remote ischemic conditioning is a procedure purported to reduce the ischemic injury of an organ. This study aimed to explore the efficiency and safety of remote ischemic conditioning in patients with acute ischemic stroke. We hypothesized that remote ischemic conditioning administered from the first day of hospital admission would improve the infarct volume and clinical outcome at 180 days.Material and Methods: We performed a unicentric double-blind randomized controlled trial. We included all patients consecutively admitted to an Emergency Neurology Department with acute ischemic stroke, ineligible for reperfusion treatment, up to 24 hours from onset. All subjects were assigned to receive secondary stroke prevention treatment along with remote ischemic conditioning on the non-paretic upper limb during the first 5 days of hospitalization, twice daily - a blood pressure cuff placed around the arm was inflated to 20 mmHg above the systolic blood pressure (up to 180 mmHg) in the experimental group and 30 mmHg in the sham group. The primary outcome was the difference in infarct volume (measured on brain CT scan) at 180 days compared to baseline, whereas the secondary outcomes included differences in clinical scores (NIHSS, mRS, IADL, ADL) and cognitive/mood changes (MoCA, PHQ-9) at 180 days compared to baseline.Results: We enrolled 40 patients; the mean age was 65 years and 60% were men. Subjects in the interventional group had slightly better recovery in terms of disability, as demonstrated by the differences in disability scores between admission and 6 months (e.g., the median difference score for Barthel was −10 in the sham group and −17.5 in the interventional group, for ADL −2 in the sham group and −2.5 in the interventional group), as well as cognitive performance (the median difference score for MoCA was −2 in the sham group and −3 in the interventional group), but none of these differences reached statistical significance. The severity of symptoms (median difference score for NIHSS = 5 for both groups) and depression rate (median difference score for PHQ-9 = 0 for both groups) were similar in the two groups. The median difference between baseline infarct volume and final infarct volume at 6 months was slightly larger in the sham group compared to the interventional group (p = 0.4), probably due to an initial larger infarct volume in the former.Conclusion: Our results suggest that remote ischemic conditioning might improve disability and cognition. The difference between baseline infarct volume and final infarct volume at 180 days was slightly larger in the sham group.
Long-Term Follow-Up Results of Mechanical Wrist Traction as Non-Invasive Treatment for Carpal Tunnel Syndrome
Authors: Meems Margreet , Boekhorst Myrthe G. B. M. , Pop Victor J. M. 
Published: September 2021

Background: For patients with carpal tunnel syndrome (CTS), the only long-term effective treatment option is carpal tunnel release surgery. Up to one-third report recurrent symptoms, and 12% needs repeated surgery. This study aimed to evaluate the long-term effects of mechanical traction as a non-invasive treatment option for CTS compared to care as usual.Methods: Patients with electrodiagnostically confirmed CTS [N = 181; mean age, 58.1 (13.0) years; 67% women] were recruited from an outpatient neurology clinic in the Netherlands. Patients completed baseline questionnaires and randomized to the intervention group (12 treatments with mechanical traction, twice a week for 6 weeks) or care as usual. The primary clinical outcome measure was surgery during the 12-month follow-up. Secondly, we assessed symptom severity with the Boston Carpal Tunnel Questionnaire (BCTQ) at baseline and at the 12-month follow-up. Changes in CTS symptom severity between baseline and the 12-month follow-up were analyzed between groups using t-tests and a multiple linear regression analyses, adjusting for duration of complaints, age, gender, and symptom severity at baseline.Results: At the 12-month follow-up, 35 of 94 (37%) patients in the intervention group had surgery, compared to 38 of 87 (44%) in the care-as-usual group (χ12 = 0.78, p = 0.377). Symptom severity and functional status scores did not significantly differ between the intervention (n = 81) and care-as-usual group (n = 55) at follow-up. For patients who did not have surgery, BCTQ scores decreased significantly more from baseline to the 12-month follow-up in the intervention group (n = 53) compared to patients in the care-as-usual group (n = 25). For patients who did not have surgery, belonging to the intervention group and a higher BCTQ score at baseline were related to a greater decrease in BCTQ scores from baseline to the 12-month follow-up, as well as symptom severity and functional status.Conclusions: Mechanical traction is effective in reducing symptom severity compared to current conservative treatment options in standard care and can therefore benefit the large number of patients that prefer conservative treatment for CTS.Clinical Trial Registration: Clinical Trials NL44692.008.13. Registered 19 September 2013, https://clinicaltrials.gov/ct2/show/NCT01949493