bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of resistance training with risk of ovarian cancer
Authors: Buras Andrea L , Hathaway Cassandra A , Wang Tianyi , Townsend Mary K , Tworoger Shelley S 
Published: March 2021

ABSTRACTBackgroundIncreasing evidence, including multiple putative inflammatory risk factors (e.g., c‐reactive protein, and adiposity), supports that inflammation plays an important role in ovarian carcinogenesis. Resistance training (RT) is associated with lower levels of circulating inflammatory markers, independent of physical activity.MethodsWe evaluated the relationship between RT and risk of ovarian cancer accounting for other physical activity (e.g., walking) in two large prospective cohorts, the Nurses’ Health Study (NHS) and NHSII.Key ResultsIn total, analyses included 42,005 NHS participants (2000–2016) and 67,289 NHSII participants (2001–2017) with RT assessed every 4 years. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of RT with ovarian cancer risk overall and by tumor subtype, adjusting for known and putative ovarian cancer risk factors. We identified a total of 609 cases over 1,748,884 person‐years. No association was observed with overall ovarian cancer risk (RT ≥60 vs 0 min/wk, HR = 0.95, 95%CI: 0.74–1.22) or by histotype (comparable HR = 0.86 and 0.98 for type I and II tumors, respectively). Results did not differ by body mass index (Pinteraction = 0.97), or other physical activity (Pinteraction = 0.31).Conclusions & InferencesWe observed no evidence that moderate levels of RT were associated with risk of ovarian cancer. Further investigations are required to confirm these findings.
Ucuùba Fat Characterization and Use to Obtain Lipid Nanoparticles by High‐Pressure Homogenization with Full Factorial Design
Authors: Pereira Rayanne R. , Gomes Antonio T. A. , Testi Matteo , Bianchera Annalisa , Ribeiro-Costa Roseane M. , Padula Cristina , Silva Júnior José O. C. , Sonvico Fabio 
Published: March 2021

AbstractUcuùba fat was characterized and used as the lipid phase for the production of nanostructured lipid carriers (NLCs). The acid, iodine, refraction, and saponification values as well as the oxidative stability of the fat were determined. The myristic acid was found to be the main fatty acid present in the fat. NLCs were produced by high‐pressure homogenization with tocopheryl polyethylene glycol 1000 succinate (TPGS) or Tween 80 as surfactant. A full factorial experimental design 22 was applied to evaluate the impact of production parameters on particle size and polydispersity index (PDI) of the nanocarrier. The design of experiments (DoE) demonstrated that the increase of pressure and number cycle homogenization positively contributed to reduce the mean particle size and PDI of NLCs only when TPGS was present.
Watermelon Peel‐Derived Heteroatom‐Doped Hierarchical Porous Carbon as a High‐Performance Electrode Material for Supercapacitors
Authors: Zhang Pei , Mu Jiahui , Guo Ziyu , Wong Shao Ing , Sunarso Jaka , Zhao Yi , Xing Wei , Zhou Jin , Zhuo Shuping 
Published: March 2021

AbstractThis work presents for the first time the systematic characterization and excellent supercapacitor performance of heteroatom‐doped porous carbon materials (HPC) synthesized by direct pyrolysis of watermelon peel and urea via molten salt template route in air with non‐toxic activating agent. The molten salt not only protects the derived carbon from burning during high‐temperature pyrolysis, but can also be etched to generate abundant hierarchical pores in the final products. The obtained HPC exhibits a high specific surface area of 1660 m2 g−1 and shows high specific capacitances of up to 278 F g−1 in 1 M H2SO4 electrolyte. The symmetrical device also demonstrates a remarkable specific capacitance of up to 226 F g−1 and ultrahigh initial capacitance retention of 98 % after 10,000 cycles of charge/discharge at the current density of 10 A g−1. The porous carbon produced via this green chemical activation route demonstrates great potential as electrode materials in supercapacitor.
Intercropping Pulse and Oilseed Crops in Southern Alberta
Authors: Bremer and Eric , Greer Ken 
Published: March 2021

AbstractIntercropping is the practice of growing two or more crops at the same time. While putting two crops together usually means less yield for each crop, overall productivity is often increased due to complementary growth habits. A common metric for evaluating the impact of intercropping on overall productivity is the land equivalent ratio (LER). Field trials were conducted over the past three year to evaluate the primary factors controlling LER for pulse–oilseed intercrops in southern Alberta. Earn 0.5 CEUs in Crop Management by reading the article and taking the quiz at www.certifiedcropadviser.org/education/classroom/classes/942.
Diagnosis of solid tumors in infants by fine‐needle aspiration cytology: 5 years retrospective study from a tertiary care oncology center in South India
Authors: Mukundapai Malathi , Agrawal Mohit , Nargund Ashwini , Patil Okaly Geeta V. , Kavitha B. L. , Padma M. , Madhu S. D. 
Published: March 2021

AbstractIntroductionNeuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytology (FNAC) is a safe, minimally invasive and outpatient procedure which is time and cost‐effective for solid tumor diagnosis. This study aims to evaluate the role of FNAC in the diagnosis of various infantile solid tumors.MethodsIn this retrospective study, 61 cases of FNA of infant solid tumors were retrieved from the cytology archives over a period of 5 years from January 2013 to December 2017. Cytomorphology was studied and immunohistochemistry on cell block was performed wherever feasible. Histopathological correlation was done in 19 cases.ResultsOf the 61 cases studied, 60 cases were included in the study of which 35 were male and 25 were female. Infantile solid tumors constituted 7.3% of all pediatric solid tumors reported in cytopathology division of our Institute. The most common final diagnosis was NB (15, 25%) followed by HBL (13, 21.6%), WT (10, 16.6%), RMS (nine, 15%) and GCT (nine, 15%). The commonest site was abdominal‐pelvic (42, 70%). A definitive independent diagnosis could be made on FNA in 48 cases (80%). Follow‐up was done for 1.5 to 4 years (mean 26 months). The highest and lowest mortality was noted in NB (64.3%) and WT (12.5%) respectively.ConclusionThis study concludes that FNAC can be adopted as a diagnostic modality in infant solid tumors.
Spotted hyaena Crocuta crocuta feeding ecology and selectivity of large herbivorous prey in the Namib desert
Authors: Fester Karl Sebastian Moritz , Hockings Georgina , van Vuuren Rudie Jansen , van Vuuren Marlice 
Published: March 2021

AbstractWe have investigated the relationship between spotted hyaenas in the south Namib Desert and large herbivorous prey and have summarized an updated overview of predator‐prey relationships in this resource‐limited arid environment. Over the 52‐month study, we recorded the densities (#/km−2, ±SE) of the four local large herbivorous prey species: gemsbok (1.229, ±0.50), springbok (1.352, ±0.48), ostrich (0.648, ±0.23), and greater kudu (0.343, ±0.00). A fecal analysis was performed on 146 collected spotted hyaena scats, and prey items were identified and hairs cross‐follicle analyzed to the species level. Spotted hyaena diet at the study area remained opportunistic with 240 identified prey items representing eight differing prey species being recorded, ranging from ostrich eggs to large ungulates. The Ivlev's Electivity Index was used to determine which large herbivorous prey was most selected for. Although gemsbok had a higher representation of prey items in the sampled scats, all sampled large herbivorous prey species scored below 0 and are thus generally avoided in relation to their availability in the environment. If any prey preferences are expressed by spotted hyaena in the Namib, it can be presumed to be a nonsampled prey species. We therefore promote further detailed investigations into all other prey species present, and seasonal variations of prey densities and scat sampling, within the study environment.
Plasma P‐selectin is a predictor of mortality in heart failure with preserved ejection fraction
Authors: Kanagala Prathap , Arnold Jayanth R. , Khan Jamal N. , Singh Anvesha , Gulsin Gaurav S. , Squire Iain B. , McCann Gerry P. , Ng Leong L. 
Published: March 2021

AbstractAimsThe aim of the study was to assess the association of P‐selectin with outcomes in heart failure with preserved ejection fraction (HFpEF).Methods and resultsThis is a prospective, observational study of 130 HFpEF patients who underwent clinical profiling, blood sampling, 6 min walk testing, Minnesota Living with Heart Failure Questionnaire evaluation, echocardiography, cardiovascular magnetic resonance imaging, calculation of the Meta‐Analysis Global Group in Chronic Heart Failure (MAGGIC) risk scores, and blinded plasma P‐selectin measurement. Patients were followed up for the endpoint of all‐cause mortality. The HFpEF subgroup with higher P‐selectin levels [overall median 26 372, inter‐quartile range (19 360–34 889) pg/mL] was associated with lower age, higher heart rate, less prevalent atrial fibrillation, more frequent current smoking status, and lower right ventricular end‐diastolic volumes. During follow‐up (median 1428 days), there were 38 deaths. Following maximal sensitivity and specificity receiver operating characteristic curve analysis, P‐selectin levels above 35 506 pg/mL were associated with greater risk of all‐cause mortality [hazard ratio (HR) 2.700; 95% confidence interval (CI) 1.416–5.146; log‐rank P = 0.002]. Following multivariable Cox proportional hazards regression analysis and when added to MAGGIC scores, only P‐selectin (adjusted HR 1.707; 95% CI 1.099–2.650; P < 0.017) and myocardial infarction detected by cardiovascular magnetic resonance imaging (HR 2.377; 95% CI 1.114–5.075; P < 0.025) remained significant predictors. In a final model comprising all three parameters, only P‐selectin (HR 1.447; 95% CI 1.130–1.853; P < 0.003) and MAGGIC scores (HR 1.555; 95% CI 1.136–2.129; P < 0.006) remained independent predictors of death. Adding P‐selectin (0.618, P = 0.035) improved the area under the receiver operating characteristic curve for mortality prediction for MAGGIC scores (0.647, P = 0.009) to 0.710, P < 0.0001.ConclusionsPlasma P‐selectin is an independent predictor of mortality and provides incremental prognostic information beyond MAGGIC scores in HFpEF.
Remarkable Effect of tert‐Amine Additives in the Asymmetric Direct Michael Reaction of Ketones with β‐Arylnitroethenes Catalyzed by an L‐Hydroxyproline‐Based Amino Tf‐Amide Organocatalyst
Authors: Lu Hanbin , Lv Jiamin , Zhou Canhua , Zhou Mi , Fang Yanxiong , Dong Jinxiang , Kato Terumasa , Liu Yan , Maruoka Keiji 
Published: March 2021

AbstractA catalytic asymmetric direct Michael reaction of ketones with trans‐β‐arylnitroethenes can be achieved under the influence of optically pure L‐hydroxyproline‐based secondary‐amino aromatic Tf‐amide organocatalyst. The effect of the trialkylamine base additive such as diethylmethylamine is of paramount importance to accomplish high reactivity and enantioselectivity in this asymmetric Michael reaction.
Don’t tell me about my moral failures but motivate me to improve: Increasing effectiveness of outgroup criticism by criticizing one’s competence
Authors: Rösler Inga K. , van Nunspeet Félice , Ellemers Naomi 
Published: March 2021

AbstractCriticizing people on their prior moral failures often causes them to react defensively, especially when this is done by an outgroup. In the current research, we tested whether people become more receptive to such outgroup criticism when it refers to (failures of) their competence, rather than their morality. We conducted two studies, using a 2: Critic's group‐membership (receiving criticism from an ingroup vs. outgroup) × 2: Dimension (competence vs. morality as focal concern addressed with the criticism) mixed design. Findings showed that, regardless of source, participants made fewer negative attributions, were more motivated to improve, and more often indicated they changed their behavior after they had been criticized on their competence, instead of on their morality. Thus, criticizing past behavior for failing to show competence instead of morality might be a way to reduce defensive responses and to stimulate behavior change, even for outgroup critics.
An Ultra‐sensitive Electrochemiluminescent Detection of Carcinoembryonic Antigen Using a Hollowed‐out Electrode
Authors: Liu Gen , Gao Hui , Chen Jiajia , Shao Congying , Chen Feifei 
Published: March 2021

AbstractUltrasensitive detection of cancer biomarkers has attracted considerable attention recently in academic research and clinic diagnostics. Here, we use a hollowed‐out carbon nanotube sponge (CNTSP) electrode to fabricate an immunosensor to realize the sensitive detection of carcinoembryonic antigen (CEA). Nitrogen‐doped carbon quantum dots (N‐CDs) are combined with antibody that can specially recognize CEA and used as the electrochemiluminescent (ECL) probes in this work. The hollowed‐out and permeable CNTSP facilitates chemical species exchange on the surface of electrode, offering an enhanced ECL signal. The resulting ECL immunosensor enables the determination of CEA concentration to be in a wide linear range from 0.005 to 50 pg mL−1 with a detection limit of 1.4 fg mL−1. Furthermore, with good stability, acceptable precision and reproducibility, the proposed ECL assay strategy offers a wide application potential in clinical analysis.
The low‐field NMR studies the change in cellular water in tilapia fillet tissue during different drying conditions
Authors: Luo Jing , Li Min , Zhang Ying , Zheng Man , Ming Ling Chang 
Published: March 2021

AbstractThe muscle is a highly organized tissue, where there are three different moistures including free water, entrapped water, and bound water. These moistures were distributed in intercellular spaces, intracellular spaces, and other solute environments, respectively. Understanding the moisture migration in different environments is crucial to enhance energy efficiency and improve the quality of processed food. Therefore, the tilapia fillets were used to experiment, and the low‐field nuclear magnetic resonance technique is used to measure the change in different moistures during the drying process. The study found that free water is the highest when cell membranes started to rupture. In addition, it also observed that the cell membrane ruptures at different stages of drying. The result of this study provides critical information that could be used to guide the study of the dynamic mechanisms underlying drying and the development of drying technology for tilapia fillets and similar aquatic products.
Analysis of decomposition in 23 seafood products by liquid chromatography with high‐resolution mass spectrometry with sensory‐driven modeling
Authors: Self Randy L. , McLendon Michael G. , Lock Christopher M. , Hu Jinxin 
Published: March 2021

AbstractSamples of 23 seafood products were obtained internationally in processing plants and subjected to controlled decomposition to produce seven discrete quality increments. A sensory expert evaluated each sample for decomposition, using a scale of 1–100. Samples were then extracted and analyzed by liquid chromatography with high‐resolution mass spectrometry (LC‐HRMS). Untargeted data processing was performed, and a sensory‐driven Random Forest model in the R programming language for each product was created. Five samples of each quality increment were analyzed in duplicate on separate days. Scores analogous to those obtained through sensory analysis were calculated by this approach, and these were compared to the original sensory findings. Correlation values (r) were calculated from these plots and ranged from 0.971 to 0.999. The finding of decomposition state of each sample was consistent with sensory for 548 of 550 test samples (99.6%). Of the two misidentified samples, one was a false negative, and one false positive (0.2% each). One additional sample from each of the 1st, 4th, and 7th increments of each product was extracted and analyzed on a third separate day to evaluate reproducibility. The range of these triplicate calculated scores was 15 or less for all samples tested, 10 or less for 63 of the 69 triplicate tests (91%), and five or less for 41 (59%). From the models, the most predictive compounds of interest were selected, and many of these were identified using MS2 data with standard or database comparison, allowing identification of compounds indicative of decomposition in these products which have not previously been explored for this purpose.
A CRISPR/Cas9‐based method for targeted DNA methylation enables cancer initiation in B lymphocytes
Authors: Katayama Shota , Shiraishi Koichi , Gorai Naoki , Andou Masao 
Published: March 2021

AbstractTargeted DNA methylation is important for understanding transcriptional modulation and epigenetic diseases. Although CRISPR‐Cas9 has potential for this purpose, it has not yet been successfully used to efficiently introduce DNA methylation and induce epigenetic diseases. We herein developed a new system that enables the replacement of an unmethylated promoter with a methylated promoter through microhomology‐mediated end joining‐based knock‐in. We successfully introduced an approximately 100% DNA methylation ratio at the cancer‐associated gene SP3 in HEK293 cells. Moreover, engineered SP3 promoter hypermethylation led to transcriptional suppression in human B lymphocytes and induced B‐cell lymphoma. Our system provides a promising framework for targeted DNA methylation and cancer initiation through epimutations.
Treatment and Renal Outcomes Up to 96 Weeks After Tenofovir Alafenamide Switch From Tenofovir Disoproxil Fumarate in Routine Practice
Authors: Toyoda Hidenori , Leong Jennifer , Landis Charles , Atsukawa Masanori , Watanabe Tsunamasa , Huang Daniel Q. , Liu Joanne , Quek Sabrina Xin Zi , Ishikawa Toru , Arai Taeang , Yokohama Keisuke , Chuma Makoto , Takaguchi Koichi , Uojima Haruki , Senoo Tomonori , Dang Hansen , Maeda Mayumi , Hoang Joseph , Le Richard H. , Yasuda Satoshi , Thin Khin N. , Tran Sally , Chien Nicholas , Henry Linda , Asai Akira , Fukunishi Shinya , Cheung Ramsey , Lim Seng Gee , Trinh Huy N. , Nguyen Mindie H. 
Published: March 2021

Background and Aims
Real‐world data for treatment effectiveness and renal outcomes in chronic hepatitis B (CHB) patients who were switched to the new and safer prodrug tenofovir alafenamide (TAF) from tenofovir disoproxil fumarate (TDF) are limited. Therefore, we aimed to evaluate treatment and renal outcomes of this population.

Approach and Results
We analyzed 834 patients with CHB previously treated with TDF for ≥12 months who were switched to TAF in routine practice at 13 US and Asian centers for changes in viral (HBV DNA < 20 IU/mL), biochemical (alanine aminotransferase [ALT] < 35/25 U/L for male/female), and complete (viral+biochemical) responses, as well as estimated glomerular filtration rate (eGFR; milliliters per minute per 1.73 square meters) up to 96 weeks after switch. Viral suppression (P < 0.001) and ALT normalization (P = 0.003) rates increased significantly after switch, with a trend for increasing complete response (P
trend = 0.004), while the eGFR trend (P
trend > 0.44) or mean eGFR (P > 0.83, adjusted for age, sex, baseline eGFR, and diabetes, hypertension, or cirrhosis by generalized linear modeling) remained stable. However, among those with baseline eGFR < 90 (chronic kidney disease [CKD] stage ≥2), mean eGFR decreased significantly while on TDF (P = 0.029) but not after TAF switch (P = 0.90). By week 96, 21% (55/267) of patients with CKD stage 2 at switch improved to stage 1 and 35% (30/85) of CKD stage 3‐5 patients improved to stage 2 and 1.2% (1/85) to stage 1.

Conclusions
Overall, we observed continued improvement in virologic response, ALT normalization, and no significant changes in eGFR following switch to TAF from TDF.
Hybrid Spaces: Adolescent Literacy and Learning in a Museum
Authors: Hamilton Erica R. , Van Duinen Deborah V. 
Published: March 2021

AbstractLearning how to teach in a hybrid space, such as a museum, opens up possibilities for preservice teachers to expand their definitions of literacy and experience teaching and learning with adolescents in new ways. This two‐year study reports findings from a university‐museum partnership in which preservice teachers (N = 81) worked with sixth‐grade students each week in a museum setting. Findings suggest that being in this hybrid space provided opportunities for preservice teachers to expand their definitions of literacy and text as well as extend and enhance sixth‐graders' curricular connections. Teaching in a hybrid space also provided new opportunities to think about adolescents as learners, including the repositioning of secondary students as teachers. Finally, this study’s findings demonstrate the importance of learning how to connect and use hybrid spaces to support adolescents’ learning and literacy development.
The selective toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) on oral squamous cell carcinoma (OSCC) by targeting their mitochondria
Authors: Afrasiabi Mona , Seydi Enayatollah , Rahimi Shabnam , Tahmasebi Ghazaleh , Jahanbani Jahanfar , Pourahmad Jalal 
Published: March 2021

AbstractIn recent years, many researchers have made tremendous efforts into using nanotechnology in biomedical applications and science, such as magnetic resonance imaging, drug delivery, and in particular, oncological therapeutic via superparamagnetic iron oxide nanoparticles (SPIONs). Head and neck squamous cell carcinoma (HNSCC) and especially oral squamous cell carcinoma (OSCC) have been a serious and ongoing concern. There are many strong emphases on the importance of toxic mechanisms due to oxidative stress and specifically, the changed cellular response. Therefore, our study was designed to evaluate the effects of SPIONs on OSCC mitochondria because of the usefulness of the application of these nanoparticles in cancer treatment and diagnosis. An increased level of reactive oxygen species (ROS) is one of the substantial mechanisms found for SPIONs in this study, and initially originated from disruption of the electron transfer chain shown by a decrease in mitochondrial succinate dehydrogenase activity. Increased ROS formation subsequently followed a decline of mitochondrial membrane potential, the release of mitochondrial cytochrome complex, and mitochondrial swelling in the OSCC mitochondria compared with almost no effect in normal mitochondria. In addition, the SPIONs decreased cell viability and increased lipid peroxidation level and caspase‐3 activity in OSCC cells. The results represented that the exposure to the SPIONs induced selective toxicity only on the OSCC but not normal mitochondria. Based on our findings, we finally concluded that the SPIONs may be considered as a potential therapeutic candidate for the treatment of OSCC.