bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potassium, an important element to improve water use efficiency and growth parameters in quinoa (Chenopodium quinoa) under saline conditions
Authors: Turcios Ariel E. , Papenbrock Jutta , Tränkner Merle 
Published: January 2021

AbstractDue to changes in the ecosystem and misuse of resources, salinity also increases. Approximately 20% of all irrigated land is affected by salinity and this will increase over time. Therefore, it is necessary to develop more environmentally friendly agricultural techniques but also to exploit potential crops with high nutritional value and tolerance to salinity like quinoa (Chenopodium quinoa Willd.). In this context, potassium is an essential macronutrient for plant growth and development. Furthermore, one of the strategies of some salt‐tolerant plants is to increase the uptake of potassium under saline conditions such that the K+/Na+ ratio is maintained for a proper osmotic regulation in cells. Therefore, a study was conducted to investigate the effect of different concentrations of potassium (0.5, 2 and 6 mM K) on quinoa under different salinities (0, 100 and 200 mM NaCl). According to the results, an adequate supply of potassium under moderate salinity conditions benefited the plant growth, with a higher potassium uptake in the presence of salt. Under saline conditions, plant transpiration decreased significantly with a high correlation with stomatal density and a greater water use efficiency. Therefore, under saline conditions, adequate doses of potassium are highly recommended in quinoa cultivation.
Effect of intensive care unit diary on incidence of posttraumatic stress disorder, anxiety, and depression of adult intensive care unit survivors: A systematic review and meta‐analysis
Authors: Sun Xihui , Huang Debin , Zeng Fan , Ye Qiao , Xiao Huineng , Lv Deping , Zhao Ping , Cui Xueting 
Published: January 2021

AbstractAimTo systematically evaluate the effect of intensive care unit diary psychotherapy on the incidence of posttraumatic stress disorder, anxiety, and depression after discharge from intensive care unit.BackgroundMany studies have reported the potential advantages and risks of intensive care unit diary psychotherapy in adult patients discharged from intensive care unit, but the results are divergent.DesignSystematic review and meta‐analysis of prospective randomized controlled or case‐controlled studies.Data sourceDatabases such as Cochran Library, Pubmed, Embase, CINAHL, and ProQuest databases, China national knowledge infrastructure (CNKI) were searched for literatures published from January 2000–March 2020.Review methodsWe use the Cochrane Risk of Bias Tool for quality assessment and audit manager 5.3 software for meta‐analysis. The main result is the incidence of posttraumatic stress disorder, anxiety, and depression.ResultsTen studies meeting the inclusion criteria were identified, including eight randomized controlled studies and two case‐controlled studies, with a total of 1,210 patients. The pooled results of this meta‐analysis indicated that the intensive care unit diary could reduce the incidence of posttraumatic stress disorder, anxiety, and depression.ConclusionThis study showed that an intensive care unit diary could improve the psychological symptoms of adult intensive care unit patients after discharge. However, due to limitations such as publication bias and case sample size, the results should be carefully considered. Researchers need to further clarify the multidisciplinary collaborative process of intensive care unit diary therapy, the real beneficiaries, and its impact on family members' psychological status by conducting large, robust studies in the future.ImpactThis study's findings suggest that medical staff need to re‐examine the role of intensive care unit diary therapy, its standardized implementation and provide effective intervention for reducing psychological stress‐related symptoms of intensive care unit patients after discharge.
Association between illness perception and health behaviour among stroke patients: The mediation effect of coping style
Authors: Liu Yanjin , Wei Miao , Guo Lina , Guo Yuanli , Zhu Yiru , He Yv 
Published: January 2021

AbstractAimsThis study aims to explore illness perception and coping style in relation to health behaviour and the mediating role of coping style between illness perception and health behaviour among stroke patients.DesignCross‐sectional study.MethodsThis survey was conducted with 515 stroke patients aged ≥18 years from September 2019 to January 2020 in Zhengzhou, China. The demographic and clinical characteristics questionnaire, Stroke Illness Perception Questionnaire‐Revised, Simplified Coping Style Questionnaire, and Health Behavior Scale for Stroke Patients were included in this study. Data analysis was performed by correlation analysis, multiple linear regression analysis, and structural equation modelling.ResultsThe valid questionnaires were 495 (effective response rate: 96.1%). Low negative illness perception, high positive coping style, and low negative coping style are related to high level of health promoting behaviour (all p < 0.01). The results revealed that the effect of illness perception on health behaviour was partly mediated by coping style. It also confirmed that the mediation effect accounts for 43.7% (−0.169/−0.387) of the total effect.ConclusionIllness perception may influence health behaviour partly because of coping style.ImpactThis study implies that targeted interventions for stroke patients' illness perception are needed to motivate them to take proactive coping strategy to ultimately improve their health behaviours.
Health and service use of newcomers and other adults with intellectual and developmental disabilities: A population‐based study
Authors: Durbin Anna , Jung James K. H. , Chung Hannah , Lin Elizabeth , Balogh Robert , Lunsky Yona 
Published: January 2021

AbstractBackgroundThis study examines newcomers with intellectual and developmental disabilities compared to other adults with intellectual and developmental disabilities in Ontario, Canada.MethodsThis population‐based retrospective cohort study used linked health and social services administrative data to identify adults with intellectual and developmental disabilities as newcomers, or non‐newcomers, and compared their health status and health service outcomes.ResultsAmong those with intellectual and developmental disabilities, compared to non‐newcomers, newcomers generally had lower or similar rates of health issues, except for higher rates of psychosis. Newcomers also had slightly greater use of community‐based health services, but less hospital use.ConclusionTrends among those with the intellectual and developmental disabilities were consistent with general population trends; newcomers had lower rates of many health issues and lower hospital use. It also underscores the value of understanding drivers of heterogeneity within newcomers, such as the circumstances of admission and settlement in their new country.
A novel treatment for esophageal lesions following atrial fibrillation ablation
Authors: Rivarola Esteban W. R. , Moura Eduardo , Chou Marco , Feitosa Seabra Luciana , Hardy Carina , Scanavacca Mauricio 
Published: January 2021

AbstractThis study presents a novel technique for the treatment of a deep esophageal ulcer after ablation of paroxysmal atrial fibrillation (AF). Pulmonary vein isolation was performed using a radiofrequency irrigated tip catheter. On Day 5 of follow‐up, a deep esophageal ulcer was observed. No significant visual improvement was observed after conventional treatment. Endoscopic negative pressure therapy in the esophagus was then applied for 5 days. A significant decrease in diameter and depth of the lesion was observed, possibly preventing perforation. Endoscopic negative pressure therapy can be used to heal thermal lesions after AF ablation procedures.
Feasibility of intraprocedural integration of cardiac CT to guide left ventricular lead implantation for CRT upgrades
Authors: Gould Justin , Sidhu Baldeep S. , Sieniewicz Benjamin J. , Porter Bradley , Lee Angela W. C. , Razeghi Orod , Behar Jonathan M. , Mehta Vishal , Elliott Mark K. , Toth Daniel , Haberland Ulrike , Razavi Reza , Rajani Ronak , Niederer Steven , Rinaldi Christopher A. 
Published: January 2021

AbstractBackgroundOptimal positioning of the left ventricular (LV) lead is an important determinant of cardiac resynchronization therapy (CRT) response.ObjectiveEvaluate the feasibility of intraprocedural integration of cardiac computed tomography (CT) to guide LV lead implantation for CRT upgrades.MethodsPatients undergoing LV lead upgrade underwent ECG‐gated cardiac CT dyssynchrony and LV scar assessment. Target American Heart Association segment selection was determined using latest non‐scarred mechanically activating segments overlaid onto real‐time fluoroscopy with image co‐registration to guide optimal LV lead implantation. Hemodynamic validation was performed using a pressure wire in the LV cavity (dP/dtmax)).Results18 patients (male 94%, 55.6% ischemic cardiomyopathy) with RV pacing burden 60.0 ± 43.7% and mean QRS duration 154 ± 30 ms underwent cardiac CT. 10/10 ischemic patients had CT evidence of scar and these segments were excluded as targets. Seventeen out of 18 (94%) patients underwent successful LV lead implantation with delivery to the CT target segment in 15 out of 18 (83%) of patients. Acute hemodynamic response (dP/dtmax ≥ 10%) was superior with LV stimulation in CT target versus nontarget segments (83.3% vs. 25.0%; p = .012). Reverse remodeling at 6 months (LV end‐systolic volume improvement ≥15%) occurred in 60% of subjects (4/8 [50.0%] ischemic cardiomyopathy vs. 5/7 [71.4%] nonischemic cardiomyopathy, p = .608).ConclusionIntraprocedural integration of cardiac CT to guide optimal LV lead placement is feasible with superior hemodynamics when pacing in CT target segments and favorable volumetric response rates, despite a high proportion of patients with ischemic cardiomyopathy. Multicentre, randomized controlled studies are needed to evaluate whether intraprocedural integration of cardiac CT is superior to standard care.
Ventricular fibrillation in a left ventricular assist device patient: Can the echocardiogram be misleading?
Authors: Singh Manavotam , Malik Nitin , Brar Vijaywant , Bering Patrick T. , Hadadi Cyrus , Sheikh Farooq H. , Lam Phillip H. 
Published: January 2021

AbstractSustained ventricular tachycardia and ventricular fibrillation (VF) are life‐threatening arrhythmias which remain highly prevalent in patients with advanced heart failure. These ventricular arrhythmias may impair the support provided by continuous‐flow left ventricular assist devices (CF‐LVADs) and lead to frequent hospitalizations, antiarrhythmic medication use, external defibrillations, and need for heart transplantation. We report a case in which a patient with a CF‐LVAD and an implantable cardioverter defibrillator at end of life presented with asymptomatic low‐flow alarms and was found to have VF of unknown duration. Unique in our case was the presence of apparent organized contractility and rhythmic opening of the mitral valve on echocardiogram despite VF on electrocardiogram.
Cardiac troponin release following left bundle branch pacing
Authors: Ponnusamy Shunumuga S. , Patel Neil R. , Naperkowski Angela , Subzposh Faiz A. , Vijayaraman Pugazhendhi 
Published: January 2021

AbstractLeft bundle branch pacing (LBBP) has emerged as an alternative to His bundle pacing (HBP) to achieve physiologic ventricular stimulation. The extent of myocardial injury during permanent LBBP implantation is currently not known. The aim of the study was to prospectively assess the extent of myocardial injury during LBBP implantation. Cardiac troponin (cTn) levels were measured at baseline and 6–12 h following permanent LBBP. The number of attempts to achieve LBBP was documented. Troponin levels were measured in a control population undergoing other electrophysiology procedures including HBP, other devices involving right ventricular (RV) pacing, radiofrequency ablation for atrial fibrillation (AF) and supraventricular tachycardia (SVT). Significant elevation of troponin (SET) was defined as threefold increase above the upper reference limit (URL) for cTn. Between December 2019 and April 2020, 204 were prospectively enrolled: LBBP in 98 and Control group 106 (SVT, 55; AF, 20; HBP, 17; other devices, 14). SET (>3× URL) was seen in 49.4% of patients in the LBBP group compared to 58.4% in the control group (p = .23). Peak troponin levels were greater in the control group compared to the LBBP group (230.3 ± 320.1 vs. 87.4 ± 71.3 pg/ml; p = .0001). Compared to LBBP (49.4%), SET was observed less frequently following HBP (17.5%; p = .01), and other device implantation (29%; p = .15). Patients requiring >2 attempts (n = 33) had significantly higher incidence of SET compared to <2 attempts (n = 56; 66.7% vs. 39.3%; p = .01). LBBP implantation is associated with myocardial injury. Asymptomatic troponin release following LBBP is less than or comparable to other interventional electrophysiology procedures.
Catheter ablation of atrial fibrillation using ablation index‐guided high‐power technique: Frankfurt AI high‐power 15‐month follow‐up
Authors: Chen Shaojie , Schmidt Boris , Bordignon Stefano , Tohoku Shota , Urban Verena C. , Schulte‐Hahn Britta , Chun K. R. Julian 
Published: January 2021

AbstractBackgroundRadiofrequency (RF) high‐power ablation appears to be a novel concept in treating atrial fibrillation (AF). The ablation‐index (AI) has been linked with the durability of pulmonary vein isolation (PVI). To report the midterm clinical results of a new ablation strategy using AI‐guided high‐power (50 W) ablation (AI‐HP).Methods and ResultsSymptomatic AF patients were included and underwent wide‐area circumferential PVI. Contact‐force catheters were used, RF power was set to 50 W targeting AI values (550/400 for anterior/posterior) and interlesion distance 6 mm. Luminal esophageal temperature (LET) was monitored during the procedure; patients with LET ≥39°C underwent post‐ablation esophageal‐endoscopy. Seventy‐two‐hour‐Holter ECGs were scheduled during follow‐up. Procedural PVI was achieved in all (N = 122; mean age, 68.2 years; male, 71.3%) patients, rate of first‐pass PVI was 96.7% per patient. Procedural mean RF time was 11.5 min, and mean RF time during posterior wall segment was 3.1 min. Per RF‐lesion, the mean contact force, RF duration, AI, and impedance‐drop at anterior/posterior wall were 26 ± 14 g/23 ± 12 g, 16.2 ± 7.5 s/8.8 ± 3.6 s, 552 ± 53/438 ± 47, and 13 ± 6 Ω/9 ± 5 Ω, respectively. Mean PVI procedural‐time, 55.8 min; mean procedural fluoroscopic time, 5.6 min. Three (2.5%) patients had asymptomatic endoscopic small erosion/erythema esophageal lesions, no serious adverse events were observed. During a 15‐month follow‐up, overall single‐procedure freedom from clinical recurrence of AF/atrial tachycardia (AT) off antiarrhythmic drug after blanking period was 85.2% (89.4% for paroxysmal AF, 80.4% for persistent AF).ConclusionThe AI‐HP (50 W) appears as an efficient ablation technique in treating AF and leads to a high single‐procedure arrhythmia‐free survival at 15 months.
Telemedicine in the management of hypertension: Evolving technological platforms for blood pressure telemonitoring
Authors: Wang Ji‐Guang , Li Yan , Chia Yook‐Chin , Cheng Hao‐Min , Minh Huynh Van , Siddique Saulat , Sogunuru Guru Prasad , Tay Jam Chin , Teo Boon Wee , Tsoi Kelvin , Turana Yuda , Wang Tzung‐Dau , Zhang Yu‐Qing , Kario Kazuomi ,   the Hypertension Cardiovascular Outcome Prevention, Evidence (HOPE) Asia Network
Published: January 2021

AbstractThe prevalence of hypertension is high and still increasing in almost all communities regardless of high, middle, or low income. The control rate remains low in most countries. Telemedicine offers possibilities to improve blood pressure control. The past two decades witnessed the fast evolving telecommunication from telephone transmission to smart mobile phone technology for telemedicine. There is some evidence from randomized controlled trials that telemonitoring improves blood pressure control. However, it requires co‐interventions. The emerging new technology may offer even more possibilities in telemonitoring and co‐interventions, for instance, an interactive platform between patients and health professionals for the management of hypertension. Telemedicine might ultimately change the situation of the unsatisfactory management of hypertension in many communities. It helps fully utilize antihypertensive treatment, the most effective cardiovascular prevention, to achieve the goal of ending atherosclerosis and arteriosclerosis in humans.
The phenotypic and functional study of tissue B cells in respiratory system provided important information for diseases and development of vaccines
Authors: Fan Li , Wu Qiongli , Kang Shuangpeng , Yang Binyan , Wu Changyou 
Published: January 2021

AbstractThe field of tissue‐resident B cells has received increasing attention, yet the feature of tissue B cells in respiratory system is unclear. Here, we first show that non‐circulating B cells obtained from nasal, trachea and lung tissues are numerically and phenotypically distinct from their circulating counterparts. Analysis of single cell transcriptome sequence identified multiple differentially expressed genes between non‐circulating B cells and circulating B cells, which illustrated their heterogeneity. Furthermore, we found high expression of CXCR3 on non‐circulating B cells, and the chemokine CXCL11 was also up‐regulated in the respiratory tissues, suggesting that CXCR3‐CXCL11 axis might accelerate the local resident of non‐circulating B cells in respiratory tract. Interestingly, intranasal immunization with BCG in mice elicited a sustained humoral immune response via induction of IgA and IgG Abs, which revealed the role of B cells. Meanwhile, tissue‐resident B cells, IgA+ and IgG+ memory B cells (MBCs) in respiratory tissues, as well as plasma cells in bone marrow, were expanded and maintained, and these subsets probably developed into antibody‐producing cells to participate in the local humoral immunity. Our data illustrate the phenotype and function of tissue B cells in the upper and lower airways, provide references for the prospective development of vaccines.
The influence of the interaction between staging, grading and extent on tooth loss due to periodontitis
Authors: Ravidà Andrea , Qazi Musa , Rodriguez Maria V. , Galli Matthew , Saleh Muhammad H. A. , Troiano Giuseppe , Wang Hom‐Lay 
Published: January 2021

AbstractAimTo assess the ability of two‐way interactions between baseline stage, grade and extent to predict tooth loss due to periodontitis (TLP) over a long‐term follow‐up period.Materials and MethodsPatients treated for periodontal disease with a complete medical history, baseline periodontal chart, full mouth radiographs and a minimum of ≥10 years follow‐up were recruited. Supportive periodontal therapy (SPT) visits were recorded during the entire follow‐up period. Patients were categorized according to their stage, grade and extent. The absolute survival at 10‐, 20‐, and 30‐year follow‐up was calculated for TLP. Kaplan–Meier survival curves were plotted at the tooth‐level and multilevel Cox regression frailty models were constructed in order to assess the association among predictive variables and TLP by taking into account the hierarchical patient‐teeth structure.Results442 patients (11,125 teeth) with a mean follow‐up of 23 years met the inclusion criteria and were included in this study. The most prevalent diagnosis at baseline was stage III grade B (30.3%), followed by stage II grade B (23.5%). Among the parameters analysed, stage and grade were found to be the best predictors of TLP. Statistically significant differences were observed for extent only in patients with severe disease (stage IV or grade C). The multilevel Cox regression analysis demonstrated that patients with higher concomitant baseline staging and grading developed greater TLP over the follow‐up period.ConclusionsHigher concomitant staging and grading corresponded to greater risk for TLP and generalized extent only became a significant predictor in patients with stage IV or grade C disease.
The evolution of red blood cell shape in fishes
Authors: Martins Brenda Oliveira , Franco‐Belussi Lilian , Siqueira Mayara Schueroff , Fernandes Carlos E. , Provete Diogo B. 
Published: January 2021

AbstractThe size and shape of red blood cells (RBCs) provide key information on life‐history strategies in vertebrates. However, little is known about how RBC shape evolved in response to environmental factors, body size and the role of evolutionary rate. Here, we analysed RBC morphometrics in a set of Teleostei (bony fishes) and Elasmobranchii (sharks and rays) species testing the hypothesis that phylogenetic relationship explains species occupation of morphospace. We collected data on cell and nucleus area and volume, nucleus:cytoplasm ratio and shape factor for 65 species belonging to 28 orders. Then, we built phylomorphospaces separately for bony fish and sharks and rays. To test whether phylogenetic relationships predicted phenotypic similarity, we calculated multivariate phylogenetic signal. We also estimated the evolutionary rate of RBC shape for each node and tip using ridge regression. Finally, we tested whether habitat and body size influenced RBC shape using a PGLS. We found a significant phylogenetic signal in RBC shape for bony fish, but not sharks and rays. Saltwater teleost species were more clustered than freshwater ones in the phylomorphospace, suggesting clade disparity. Accordingly, the rate of evolution was highly heterogeneous, with significant decrease in Acanthopterygii. Neither habitat nor body size influenced RBC shape. In conclusion, RBC shape seems to have evolved in fishes in response to multiple selective pressures independent of life‐history characters.
The role of the environment in the spatial dynamics of an extensive hybrid zone between two neotropical cats
Authors: Sartor Caroline Charão , Cushman Samuel Alan , Wan Ho Yi , Kretschmer Rafael , Pereira Javier A. , Bou Nadia , Cosse Mariana , González Susana , Eizirik Eduardo , de Freitas Thales Renato O. , Trigo Tatiane Campos 
Published: January 2021

AbstractIdentifying factors that create and maintain a hybrid zone is of great interest to ecology, evolution and, more recently, conservation biology. Here, we investigated the role of environmental features in shaping the spatial dynamics of a hybrid zone between the southern tigrina, Leopardus guttulus, and Geoffroy's cat, L. geoffroyi, testing for exogenous selection as the main force acting on its maintenance. These Neotropical felid species are mainly allopatric, with a restricted area of sympatry in the ecotone between the Atlantic Forest and Pampa biomes. As both biomes have experienced high rates of anthropogenic habitat alteration, we also analysed the influence of habitat conversion on the hybrid zone structure. To do this, we used 13 microsatellite loci to identify potential hybrids and generated ecological niche models for them and their parental species. We compared the influence of variables on parental species and hybrid occurrence and calculated the amount of niche overlap among them. Parental species showed different habitat requirements and predicted co‐occurrence was restricted to the forest‐grassland mosaic of the ecotone. However, hybrids were found beyond this area, mainly in the range of L. geoffroyi. Hybrids demonstrated higher tolerance to habitat alteration than parental types, with a probability of occurrence that was positively related with mosaics of cropland areas and remnants of natural vegetation. These results indicate that exogenous selection alone does not drive the dynamics of the hybrid zone, and that habitat conversion influences its structure, potentially favouring hybrids over parental species.