bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Chronic Spontaneous Urticaria With Anxiety and Depression in Adolescents: A Mediation Analysis
Authors: Huang Yuzhou , Xiao Yi , Jing Danrong , Li Jie , Zhang Jianglin , Chen Xiang , Shen Minxue 
Published: September 2021

Background: Chronic spontaneous urticaria (CSU) is related to psychiatric comorbidities. It is not clear whether the relationship is affected by modifiable factors.Objectives: To investigate whether the effect of CSU on anxiety and depression in adolescents is mediated by the symptoms of itching and sleep disturbance.Methods: Questionnaire survey was conducted among newly enrolled college students. Dermatologists diagnose skin diseases, including CSU, during health examination. Anxiety and depression were measured by the Generalized Anxiety Disorder Scale and Patient Health Questionnaire, respectively. Sleep quality was measured by the Pittsburgh Sleep Quality Index. The symptoms of itching were measured by the numeric rating scale. According to the hypothesis, the mediating effect model was put forward and the structural equation model is used to build the mediation effect model. The mediation effect model was proposed according to the hypothesis and established using a structural equation model.Results: A total of 2,358 students with no history of systemic disease and no pruritus disease (except CSU) were included in the analysis. A total of 393 CSU patients were included, and 1,965 healthy controls were selected based on age and sex matching. CSU was significantly associated with both anxiety and depression when the symptoms of itching and sleep quality were not modeled. A mediation model was proposed as CSU → itching → sleep disturbance → anxiety or depression. Itching and sleep quality mediated 65.4 and 77.6% of CSU's effects on anxiety and depression, respectively, and CSU had no significant direct effect on anxiety or depression in the mediation models.Conclusions: The associations of CSU with anxiety and depression were mediated by the symptoms of itching and sleep disturbance. Effectively reducing the symptoms of itching thereby could increase natural sleep, which can further treat the emotional disorders among patients with CSU.
Oncofertility Knowledge and Communication: Comparison Between Medical and Surgical Oncologists and Breast Cancer Patients in Academic Chinese Centers
Authors: Biskup Ewelina , Xin Zhaochen , Li Rui , Zucal John P. , Lu Yao , Sun Yun , Appiah Leslie Coker , Lindheim Steven R. , Zhang Hongwei 
Published: September 2021

Background: As cancer has become a major public health issue in China, fertility preservation remains limited despite the wide application of Assisted Reproductive Technology (ART) throughout the country.Objective: This study aimed to identify gaps in knowledge and communication as well as referrals in the previous year regarding oncofertility among medical and surgical oncologists and breast cancer patients (BCPs) in Chinese academic settings to target areas of needed improvement.Materials and Methods: A WeChat online questionnaire was designed, distributed, and compared between medical and surgical oncology specialists and reproductive age BCPs in academic teaching settings in Shanghai.Results: Sixty-one medical and surgical oncologists and 125 BCPs responded to the survey. 63.3% of oncologists were familiar with the term “oncofertility” compared to 25.6% of BCPs (p &lt; 0.001). Oncologists were more likely to correctly know the costs associated with treatment (59.0 vs. 32.0%, p &lt; 0.001); patient did not have to be married to undergo oncofertility treatment (50.8 vs. 24.8%, p &lt; 0.001). Both oncologists and BCPs were similarly unlikely to know when patients could utilize cryopreserved tissue in the future (37.7 vs. 22.2%, p = 0.056). While oncologists reported they discussed all oncofertility options (41.0%) and offered psychological counseling (98.4%), significantly fewer BCPs reported receiving information on all options and offered counseling (3.2%, p &lt; 0.001 and 85.6%, p &lt; 0.01). Knowledge of oncofertility was the most important predictor for providing and receiving counseling from oncologists [OR = 6.44 (95% CI = 1.59–26.1, p = 0.009] and BCPs (OR = 3.73 95% CI: = 1.36–10.2, p = 0.011). Overall, 57.4% of oncologists referred &lt;10 patients and none referred more than 25 patients in the past year.Conclusion: Data suggests a significant knowledge gap and ineffective communication/comprehension exists between academic Chinese oncologists and BCPs. Continued education and raised awareness are needed to optimize utilization of oncofertility services in China.
MILK PRODUCTIVITY OF BLACK-AND-WHITE CATTLE WITH DIFFERENT GENOTYPES OF PROLACTIN AND SOMATOTROPIN
Authors: ЗАГИДУЛЛИН Л.Р. , ШАЙДУЛЛИН Р.Р. , АХМЕТОВ Т.М. , ТЮЛЬКИН С.В. , МОСКВИЧЕВА А.Б. 
Published: September 2021

Изучена взаимосвязь аллельных вариантов генов пролактина и соматотропина с показателями молочной продуктивности коров черно-пестрой породы по 1 и 3 лактации. У первотелок, как и у полновозрастных животных, наиболее высокий удой (4642 и 6240 кг), количество молочного жира (174,1 и 215,0 кг) и молочного белка (149,0 и 182,5 кг) достигнуты в группе с генотипом PRL АА. По массовой доле жира и белка в молоке коровы с генотипом PRL ВВ достоверно превосходили животных с генотипом PRL АА на 0,12% (Р<0,05) и 0,05% (Р<0,05) соответственно. По гену соматотропина наибольший уровень молочной продуктивности выявлен у коров с генотипом GH LL при достоверном преимуществе над GH VV у первотелок по удою на 439 кг (Р<0,01), выходу молочного жира — на 13,6 кг (Р<0,001), выходу молочного белка — на 15,3 кг (Р<0,01). У полновозрастных коров превышение над остальными группами было только по удою — на 219—548 кг (Р<0,05). Наибольшая жирномолочность характерна животным с генотипом GH VV по 1 лактации — 3,83% и по 3 лактации — 3,82%, а лучшая белковомолочность — коровам, имеющим аллель V гена GH: 3,21 и 3,23% соответственно. Полученные данные свидетельствуют о более высоком уровне молочной продуктивности у коров с генотипом PRL АА и GH LL, но лучшая жирномолочность и белковомолочность отмечены у особей, имеющих в своем генотипе аллели В гена PRL и V гена GH.
The interrelation of allelic variants of prolactin and somatotropin genes with indicators of milk productivity of black-and-white cows for the 1st and 3rd lactation was studied. The highest milk yield (4642 and 6240 kg) amount of milk fat (174.1 and 215.0 kg) and milk protein (149.0 and 182.5 kg) were in the group with the PRL AA genotype in first-calf heifers as well as in full-age animals. In terms of the mass fraction of fat and protein of milk, the cows with the PRL BB genotype significantly exceeded animals with the PRL AA genotype by 0.12% (P<0.05) and 0.05% (P<0.05), respectively. According to the somatotropin gene, the highest level of milk productivity was revealed in cows with the GH LL genotype with a significant advantage over GH VV in first-calf heifers in milk yield by 439 kg (P<0.01), milk fat yield by 13.6 kg (P<0.001), milk protein yield by 15.3 kg (P<0.01). The excess over the other groups in full-age cows was only in terms of milk yield that was by 219-548 kg (P<0.05). The highest protein content of milk is a characteristic of animals with the GH VV genotype, 3.83% is for the 1st lactation and 3.82% is for the 3rd lactation, and the best protein content of milk in cows with V allele of the GH gene is 3.21 and 3.23%, respectively. The obtained data indicated a higher level of milk productivity in cows with the PRL AA and GH LL genotypes but the best fat and milk content was noted in cows with alleles B of the PRL gene and V of the GH gene in their genotype.
COMPARATIVE FEATURES OF DAIRY EFFICIENCY OF COWS OF THE GOLSHTEIN AND HOLSHTINIZED BLACK AND WHITE BREEDS OF THE REPUBLIC OF KAZAKHSTAN
Authors: КАРЫМСАКОВ Т.Н. , СТРЕКОЗОВ Н.И. 
Published: September 2021

В последние 20—25 лет на маточном поголовье черно-пестрого скота активно использовалось семя быков-производителей голштинской породы, завезенных по импорту из США и Канады. Это привело к тому, что в республике сформировался массив черно-пестрого скота с высокой долей кровности по улучшающей голштинской породе. Параллельно по импорту завозились и животные голштинской породы, в основном телки случного возраста и нетели. В конечном итоге в Казахстане образовались генотипы, схожие по внешним признакам, но отличающиеся по продуктивности. В статье отражены результаты научных исследований по сравнительному изучению молочной продуктивности коров двух родственных пород черно-пестрой масти. Показано, что высококровные (более 87,5 % по улучшающей породе) животные по удою на 30—43% уступали чистопородному голштинскому скоту, однако помеси на 2—4% превосходили голштинов по содержанию жира и белка в молоке. Отмечены идентичные биологические свойства обеих пород, связанные с лактационной кривой, как за полную лактацию, так и по суточным надоям. Полученные результаты обосновывают целесообразность полного поглощения значительной части казахстанской популяции черно-пестрого скота голштинской породой. Однако необходимо определенную часть животных сохранить в чистоте и на этой основе создать генофондные стада.
In the last 20—25 years, the seed of bulls-producers of the Holstein breed, imported from the USA and Canada, has been actively used on the broodstock of black-and-white cattle. This led to the formation in the republic of an array of black-and-white cattle with a high proportion of blood in the improving Holstein breed. At the same time, animals of the Holstein breed were also imported, mainly heifers of breeding age and heifers. Ultimately, genotypes were formed in Kazakhstan, similar in appearance, but differing in productivity. The article reflects the results of scientific research on a comparative study of the milk productivity of cows of two related breeds of black and white color. It has been shown that high-blooded (more than 87.5% in the improving breed) animals in milk yield were 30—43% inferior to pure-bred Holstein cattle, but hybrids exceeded Holsteins by 2—4% in fat and protein content in milk. The identical biological properties of both breeds, associated with the lactation curve, both for full lactation and for daily milk yield, were noted.
The obtained results justify the feasibility of fully absorbing a significant part of the Kazakh population of black and white cattle by the Holstein breed. However, it is necessary to keep a certain part of the animals clean and on this basis create gene-pool herds.
The Two Problems of Russian Statistics: User's Perspective.
Authors: Bessonov V. A. 
Published: September 2021

The article discusses two groups of problems in Russian statistics that still have no viable solutions. The frst one - the state of the statistics interface – is the set of channels through which users obtain statistical information. The second – metadata status – is the information on how the indicators are constructed. The problems are considered from the standpoint of consumers of statistical information, performing tasks of analyzing economic dynamics.It is concluded that with the transition from traditional printed materials to statistical information systems, interface development has come to a standstill, and in the development of metadata, there is no compliance with any standards, uniformity, and consistency. In the author's opinion, these problems seriously hinder the improvement of all Russian statistics, being a kind of blood clots. When an interface becomes a bottleneck, the value of statistics to users decreases. The unsatisfactory state of metadata leads to the fact that consumers of statistical information are not always able to use it adequately, and the problems of statistical methodology are conserved.The causes of the problems are determined, on the one hand, by the complex history of domestic statistics (extended period of development in a planned economy and the specifcs of economic transformation), and, on the other hand, by the lack of eﬀective feedback.The author considers possible approaches to addressing the problems. The expediency of creating groups of specialists in the structure of the statistical department on the main problem blocks, acting as points of growth and centers of competence, accumulating knowledge, mastering domestic and foreign experience, attracting representatives of the expert community, directing and controlling the activities to solve problems, is substantiated.
Isotope effect of rovibrational distribution of hydrogen molecules desorbed from amorphous carbon
Authors: Nakamura Hiroaki , Saito Seiki , Sawada Takumi , Sawada Keiji , Kawamura Gakushi , Kobayashi Masahiro , Hasuo Masahiro 
Published: September 2021

Abstract
When the hydrogen isotope atom is injected into the amorphous carbon with the incident energies E
in of 20, 50, and 80 eV, we obtain the following physical quantities of hydrogen isotope atoms/molecules emitted from the amorphous carbon using molecular dynamics and heat conduction hybrid simulation. The physical quantities are the time evolution of the emission rate, the depth distribution of the original location of the hydrogen emitted from the target, the polar angular dependence, and the translational, rotational, and vibrational energy distributions. In addition, the approximate analysis yields the emission distributions at the vibrational (v) and rotational (J) levels. Using these distributions, we evaluate the rotational temperature T
rot for v = 0 and small J states. From the above, it is found that molecules with higher rotational levels J tend to be emitted as E
in increases or as the mass of hydrogen isotope increases. Moreover, the isotope effect appears in the mass dependence of T
rot.
A Wolf in Sheep's Clothing: Systemic Immune Activation Post Immunotherapy
Authors: Tiu Crescens , Shinde Rajiv , Pal Abhijit , Biondo Andrea , Lee Alex , Tunariu Nina , Jhanji Shaman , Grover Vimal , Tatham Kate , Gruber Pascale , Banerji Udai , De Bono Johann S. , Nicholson Emma , Minchom Anna R. , Lopez Juanita S. 
Published: September 2021

ABSTRACT

Introduction
Immune checkpoint inhibitors (ICIs) are increasingly a standard of care for many cancers; these agents can result in immune-related adverse events (irAEs) including fever, which is common but can rarely be associated with systemic immune activation (SIA or acquired HLH).

Methods
All consecutive patients receiving ICIs in the Drug Development Unit of the Royal Marsden Hospital between May 2014 and November 2019 were retrospectively reviewed. Patients with fever ≥ 38°C or chills/rigors (without fever) ≤ 6 weeks of commencing ICIs were identified for clinical data collection.

Results
Three patients met diagnostic criteria for SIA/HLH with median time to onset of symptoms of 10 days. We describe the clinical evolution, treatment used, and outcomes for these patients. High-dose steroids are used first-line with other treatments, such as tocilizumab, immunoglobulin and therapeutic plasmapheresis can be considered for steroid-refractory SIA/HLH.

Conclusion
SIA/HLH post ICI is a rare but a potentially fatal irAE that presents with fever and a constellation of nonspecific symptoms. Early recognition and timely treatment are key to improving outcomes.
Introdu��o do fator ambiental no contempor�neo direito humanit�rio
Authors: Junior Antonio Elian Lawand 
Published: September 2021

A meta deste trabalho � analisar criticamente o tratamento jur�dico dispensado pelo direito humanit�rio � quest�o ambiental. Para tanto, observamos as g�neses dos
direitos humanos internacionalmente
protegidos e do direito ao meio ambiente,
como consect�rio do direito � vida e
propriedade. Ap�s, por meios de sintaxe
entre esses dois direitos, observamos o
direito humanit�rio em sua aplica��o ao
direito ao meio ambiente.
Os direitos de personalidade e a prote��o ao nome diante dos servi�os de prote��o ao cr�dito
Authors: Miranda Fernando Silveira Melo Plentz , Gozzo D�bora 
Published: September 2021

Este estudo tem por objetivo examinar a
quest�o do nome como direito fundamental
e a utiliza��o dos bancos de dados dos
�rg�os de prote��o ao cr�dito. O C�digo
Civil, nos direitos de personalidade tutela o
direito ao nome, elemento important�ssimo
� afirma��o do homem, sendo que o C�digo
de Defesa do Consumidor oferece prote��o
ao nome das pessoas, relativa aos cadastros
nos �rg�os de prote��o ao cr�dito.
A organiza��o regimental dos trabalhos legislativos
Authors: Junior Renato 
Published: September 2021

A atual organiza��o regimental tornou o
Legislativo o �rg�o mais eficaz e previs�vel
e isso favoreceu a governabilidade
no presidencialismo. No entanto, a
argumenta��o sobre a efici�ncia da produ��o
legislativa n�o pode constituir par�metro
para aferi��o da qualidade do processo
legislativo. Sob a teoria do discurso de
Habermas, o direito encontra legitimidade
atrav�s aceitabilidade racional da norma,
aferida pela media��o comunicativa. Assim,
questiona-se a qualidade democr�tica
de alguns institutos de algumas pr�ticas
no Congresso Nacional. O resultado � o
empobrecimento do debate parlamentar
em favor da efici�ncia legislativa.
Sobre el tema de las fuentes del Derecho en Cuba
Authors: Carrillo Juan Ram�n P�rez 
Published: September 2021

De forma general, las cuestiones sobre el ordenamiento jur�dico cubano y los elementos que lo estructuran o jerarquizan no han sido lo sufi cientemente estudiados.
Esta puede estar dado, prima facie, por otras cuestiones, quiz�s mas acuciantes en cuanto a tem�ticas de investigaci�n jur�dica; en lo personal, creo que no siempre ha sido as�. En las l�neas que soportan el presente trabajo, hemos pretendido hacer una breve referencia al tema de las fuentes del Derecho en Cuba, a partir de presupuestos generalmente admitidos en la doctrina internacional, arribando a nuestro criterio, a conclusiones claves para una certera comprensi�n de dicho ordenamiento, lo que implica la no-existencia de un
reconocimiento normativo en cuanto a las fuentes del Derecho en Cuba.
A import�ncia do trabalho do professor numa conota��o filos�fica e a liberdade de c�tedra como direito fundamental
Authors: Almeida Miriam Rodrigues Ribeiro Bicalho de 
Published: September 2021

O trabalho e a educa��o s�o princ�pios fundamentais consagrados pela sociedade, que o Direito tem por fun��o zelar e organizar. A ideia de um dever gen�rico de prote��o, fundado nos direitos fundamentais, permite que se reconhe�a a irradia��o dos efeitos desses direitos sobre toda a ordem
jur�dica. O presente trabalho visa a ressaltar a import�ncia do trabalho do professor numa vis�o hist�rico-filos�fica e questionar os limites da liberdade de c�tedra enquanto direito fundamental.
Capturing richer information: On establishing the validity of an interval-valued survey response mode
Authors: Ellerby Zack , Wagner Christian , Broomell Stephen B. 
Published: September 2021

AbstractObtaining quantitative survey responses that are both accurate and informative is crucial to a wide range of fields. Traditional and ubiquitous response formats such as Likert and visual analogue scales require condensation of responses into discrete or point values—but sometimes a range of options may better represent the correct answer. In this paper, we propose an efficient interval-valued response mode, whereby responses are made by marking an ellipse along a continuous scale. We discuss its potential to capture and quantify valuable information that would be lost using conventional approaches, while preserving a high degree of response efficiency. The information captured by the response interval may represent a possible response range—i.e., a conjunctive set, such as the real numbers between 3 and 6. Alternatively, it may reflect uncertainty in respect to a distinct response—i.e., a disjunctive set, such as a confidence interval. We then report a validation study, utilizing our recently introduced open-source software (DECSYS), to explore how interval-valued survey responses reflect experimental manipulations of several factors hypothesised to influence interval width, across multiple contexts. Results consistently indicate that respondents used interval widths effectively, and subjective participant feedback was also positive. We present this as initial empirical evidence for the efficacy and value of interval-valued response capture. Interestingly, our results also provide insight into respondents’ reasoning about the different aforementioned types of intervals—we replicate a tendency towards overconfidence for those representing epistemic uncertainty (i.e., disjunctive sets), but find intervals representing inherent range (i.e., conjunctive sets) to be well-calibrated.
Atmospheric Transmission Spectroscopy of Hot Jupiter KELT-10b using Synthetic Telluric Correction Software
Authors: McCloat Sean , von Essen Carolina , Fieber-Beyer Sherry 
Published: September 2021

Abstract
High-resolution spectroscopic visible data were obtained with the Ultraviolet and Visible Echelle Spectrograph on the Very Large Telescope. Our goal was to analyze the data in an effort to detect the presence of sodium in the atmosphere of hot Jupiter exoplanet KELT-10b, as well as characterize the orbit of the planet via the Rossiter-McLaughlin effect. Eighty spectra were collected during a single transit of KELT-10b. After standard spectroscopic calibration using ESO-Reflex, the synthetic telluric modeling software molecfit was applied to remove terrestrial atmospheric effects, and to refine the wavelength calibration. Sodium is recognized by its characteristic absorption doublet located at 5895.924 and 5889.951 Å, which can be seen in the planet atmosphere transmission spectrum and through excess absorption during the transit. The radial velocity of the host star was analyzed by measuring the average shift of absorption features from spectrum to spectrum. Our results indicate a sodium detection in the planet transmission spectrum with a line contrast of 0.66% and 0.43% ± 0.09% for the sodium DII and DI lines, respectively. Excess absorption measurements agree to within one half combined standard deviation between the planet transmission spectrum (0.143% ± 0.020%, a 7σ detection) and during the time series (0.124% ± 0.034%, a 3.6σ detection) in a band 1.25 Å wide. The wavelength grid corrections provided by molecfit were insufficient to determine radial velocities and measure the Rossiter-McLaughlin effect.
Improved Methods for Estimating Peculiar Velocity Correlation Functions Using Volume Weighting
Authors: Wang Yuyu , Peery Sarah , Feldman Hume A. , Watkins Richard 
Published: September 2021

Abstract
We present an improved method for calculating the parallel and perpendicular velocity correlation functions directly from peculiar velocity surveys using weighted maximum-likelihood estimators. A central feature of the new method is the use of a position-dependent weighting scheme that reduces the influence of nearby galaxies, which are typically overrepresented relative to more distant galaxies in most surveys. We demonstrate that correlation functions calculated in this way are less susceptible to biases due to our particular location in the universe, and thus are more easily comparable to linear theory and between surveys. Our results suggest that the parallel velocity correlation function is a promising cosmological probe, given that it provides a better approximation of a Gaussian distribution than other velocity correlation functions and that its bias is more easily minimized by weighting. Though the position-weighted parallel velocity correlation function increases the statistical uncertainty, it decreases the cosmic variance and is expected to provide more stable and tighter cosmological parameter constraints than other correlation methods in conjunction with more precise velocity surveys in the future.