bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body mass index and age are associated with ventricular end-diastolic pressure in adults with a Fontan circulation
Authors: Howell Mary , Anderson William E. , Alegria Jorge , Paolillo Joseph , Schwartz Matthew C. 
Published: October 2021

AbstractIntroduction:Systemic ventricular end-diastolic pressure is an important haemodynamic variable in adult patients with Fontan circulation. Risk factors associated with elevated end-diastolic pressure have not been clearly identified in this population.Methods:All patients > 18 years with Fontan circulation who underwent cardiac catheterisation at our centre between 1/08 and 3/19 were included. Relevant patient variables were extracted. Univariate and multivariate general linear models were analysed to identify variables associated with end-diastolic pressure.Results:Forty-two patients were included. Median age was 24.0 years (20.9–29.0) with a body mass index of 23.7 kg/m2 (21.5–29.7). 10 (23.8%) patients had a systemic right ventricle. The median (Interquartile range) and mean pulmonary artery pressure were 11.0 mmHg (9.0–12.0) and 16.0 mmHg (13.0–18.0), respectively. On univariate analysis, end-diastolic pressure was positively associated with body mass index (p < 0.01), age > 25 years (p = 0.04), symptoms of heart failure (p < 0.01), systemic ventricular systolic pressure (p = 0.03), pulmonary artery mean pressure (p < 0.01), and taking diuretics (p < 0.01) or sildenafil (p < 0.01). End-diastolic pressure was negatively associated with aortic saturation (p < 0.01). On multivariate analysis, end-diastolic pressure was positively associated with age ≥ 25 years (p < 0.01), and body mass index (p = 0.04).Conclusions:In a cohort of adult patients with Fontan circulation undergoing catheterisation, end-diastolic pressure was positively associated with age ≥ 25 years and body mass index on multivariate analysis. Maintaining a healthy body mass index may offer haemodynamic benefit in adults with Fontan physiology.
Migrating and Nerve Fibers-Associated Eosinophilic Granule Cells in the Olfactory Organ of Catfish (Clarias garpienius): Light and Electron Microscopic Evidence
Authors: Awad Mahmoud , Emeish Walaa FA , Mohamedien Dalia 
Published: October 2021

Abstract
Piscine mast cells or eosinophilic granule cells (EGCs) of fish are equivalent to the mammalian mast cells. Recently, a better understanding of EGCs functions is allowed because of the growing interest in fish models. Herein, we present a trial to furnish data regarding the distribution of the EGCs in the fish olfactory organ, an issue that has not been reported so far. Regarding their distribution, two kinds of EGCs had been identified. An intra-epithelial one was detected in the olfactory epithelium lining of the olfactory lamellae. The stromal one was identified in the connective tissue core of the olfactory lamellae and in the lamina propria underlying the olfactory epithelium. Some were detected in the capillary lumen. The cytoplasm of the EGCs reacted strongly with the MMP-9 antibody. Stimulating a migration perspective for the olfactory EGCs which was confirmed by their location in the blood capillaries. Several EGCs could be verified in close relation, some underneath the epineurium, with the nerve fiber. Mutually, this verifies the existence of intra-epithelial and stromal migrating EGCs in the catfish olfactory organ and their inclusion in the olfactory immune response. Additionally, this provides evidence for an immune–nervous interaction to influence both the immune reactions and the nervous scheme in catfish.
Aboriginal community-controlled aged care: principles, practices and actions to integrate with primary health care
Authors: Dawson Anna , Harfield Stephen , Davy Carol , Baker Anna , Kite Elaine , Aitken Graham , Morey Kim , Braunack-Mayer Annette , Brown Alex 
Published: October 2021

Abstract

Aim:
To identify: 1) best practice aged care principles and practices for Aboriginal and Torres Strait Islander older peoples, and 2) actions to integrate aged care services with Aboriginal community-controlled primary health care.

Background:
There is a growing number of older Aboriginal and Torres Strait Islander peoples and an unmet demand for accessible, culturally safe aged care services. The principles and features of aged care service delivery designed to meet the unique needs of Aboriginal and Torres Strait Islander peoples have not been extensively explored and must be understood to inform aged care policy and primary health care planning into the future.

Methods:
The research was governed by leaders from across the Aboriginal community-controlled primary health care sector who identified exemplar services to explore best practice in culturally aligned aged care. In-depth case studies were undertaken with two metropolitan Aboriginal community-controlled services. We conducted semi-structured interviews and yarning circles with 46 staff members to explore key principles, ways of working, enablers and challenges for aged care service provision. A framework approach to thematic analysis was undertaken with emergent findings reviewed and refined by participating services and the governance panel to incorporate national perspectives.

Findings:
A range of principles guided Aboriginal community-controlled aged care service delivery, such as supporting Aboriginal and Torres Strait Islander identity, connection with elders and communities and respect for self-determination. Strong governance, effective leadership and partnerships, Aboriginal and Torres Strait Islander workforce and culturally safe non-Indigenous workforce were among the identified enablers of aged care. Nine implementation actions guided the integration of aged care with primary health care service delivery. Funding limitations, workforce shortages, change management processes and difficulties with navigating the aged care system were among the reported challenges. These findings contribute to an evidence base regarding accessible, integrated, culturally safe aged care services tailored to the needs of Aboriginal and Torres Strait Islander peoples.
Heterogeneous Sediment Input at the Nankai Trough Subduction Zone: Implications for Shallow Slow Earthquake Localization
Authors: Tilley H. , Moore G. F. , Underwood M. B. , Hernández‐Molina F. J. , Yamashita M. , Kodaira S. , Nakanishi A. 
Published: October 2021

AbstractSubducted sediment plays a key role in modulating pore pressure and seismic behavior at subduction zones. We investigated the seismic character of incoming sediments to test how sediment and basement variations relate to the along‐strike changes within the accretionary prism and plate boundary conditions at the Nankai Trough. High‐resolution seismic data reveal for the first time the presence of countourite mounded drifts in the Shikoku Basin. These features have probably introduced permeability heterogeneities into an otherwise homogenous mud‐dominant unit. Additionally, we found that normal faults in this unit are more extensive than previously documented, which probably enhances along‐strike fluid transport. The wedge taper is more correlative with the thickness of the mud‐dominant facies than the turbidite thickness. This may be due to the permeability heterogeneities associated with contourite deposits and normal faults, or due to the absence of thick turbidite deposits. Turbidite deposits can either aid the drainage of the margin where they are not confined by basement topography, or contribute to high pore fluid pressures where they are confined by less permeable mudstone or basement topography. When confined turbidite deposits and contourite mounded drifts are subducted, they may contribute to localized compartments of excess pore pressure which provide the necessary conditions for slow slip behavior. We determined that along‐strike variations in seismic behavior are likely related to the subducting basement topographic and sediment characteristics, which vary on a local (<10 km) scale.
Topological holographic quench dynamics in a synthetic frequency dimension
Authors: Yu Danying , Peng Bo , Chen Xianfeng , Liu Xiong-Jun , Yuan Luqi 
Published: October 2021

AbstractThe notion of topological phases extended to dynamical systems stimulates extensive studies, of which the characterization of nonequilibrium topological invariants is a central issue and usually necessitates the information of quantum dynamics in both the time and momentum dimensions. Here, we propose the topological holographic quench dynamics in synthetic dimension, and also show it provides a highly efficient scheme to characterize photonic topological phases. A pseudospin model is constructed with ring resonators in a synthetic lattice formed by frequencies of light, and the quench dynamics is induced by initializing a trivial state, which evolves under a topological Hamiltonian. Our key prediction is that the complete topological information of the Hamiltonian is encoded in quench dynamics solely in the time dimension, and is further mapped to lower-dimensional space, manifesting the holographic features of the dynamics. In particular, two fundamental time scales emerge in the dynamical evolution, with one mimicking the topological band on the momentum dimension and the other characterizing the residue time evolution of the state after the quench. For this, a universal duality between the quench dynamics and the equilibrium topological phase of the spin model is obtained in the time dimension by extracting information from the field evolution dynamics in modulated ring systems in simulations. This work also shows that the photonic synthetic frequency dimension provides an efficient and powerful way to explore the topological nonequilibrium dynamics.
BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability
Authors: Tang Xiaozhu , guo Mengjie , Ding Pinggang , Deng Zhendong , Ke Mengying , Yuan Yuxia , Zhou Yanyan , Lin Zigen , Li Muxi , Gu Chunyan , Gu Xiaosong , Yang Ye 
Published: October 2021

AbstractMultiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow characterized by chromosome instability (CIN), which contributes to the acquisition of heterogeneity, along with MM progression, drug resistance, and relapse. In this study, we elucidated that the expression of BUB1B increased strikingly in MM patients and was closely correlated with poor outcomes. Overexpression of BUB1B facilitated cellular proliferation and induced drug resistance in vitro and in vivo, while genetic targeting BUB1B abrogated this effect. Mechanistic studies unveiled that enforced expression of BUB1B evoked CIN resulting in MM poor outcomes mainly through phosphorylating CEP170. Interestingly, we discovered the existence of circBUB1B_544aa containing the kinase catalytic center of BUB1B, which was translated by a circular RNA of BUB1B. The circBUB1B_544aa elevated in MM peripheral blood samples was closely associated with MM poor outcomes and played a synergistic effect with BUB1B on evoking CIN. In addition, MM cells could secrete circBUB1B_544aa and interfere the MM microenvironmental cells in the same manner as BUB1B full-length protein. Intriguingly, BUB1B siRNA, targeting the kinase catalytic center of both BUB1B and circBUB1B_544aa, significantly inhibited MM malignancy in vitro and in vivo. Collectively, BUB1B and circBUB1B_544aa are promising prognostic and therapeutic targets of MM.
TRIP6 functions in brain ciliogenesis
Authors: Shukla Shalmali , Haenold Ronny , Urbánek Pavel , Frappart Lucien , Monajembashi Shamci , Grigaravicius Paulius , Nagel Sigrun , Min Woo Kee , Tapias Alicia , Kassel Olivier , Heuer Heike , Wang Zhao-Qi , Ploubidou Aspasia , Herrlich Peter 
Published: October 2021

AbstractTRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component.Trip6deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly, fewer and shorter cilia, are poorly differentiated, and the mice develop hydrocephalus. TRIP6 carries numerous protein interaction domains and its functions require homodimerization. Indeed, TRIP6 disruption in vitro (in a choroid plexus epithelial cell line), via RNAi or inhibition of its homodimerization, confirms its function in ciliogenesis. Using super-resolution microscopy, we demonstrate TRIP6 localization at the pericentriolar material and along the ciliary axoneme. The requirement for homodimerization which doubles its interaction sites, its punctate localization along the axoneme, and its co-localization with other cilia components suggest a scaffold/co-transporter function for TRIP6 in cilia. Thus, this work uncovers an essential role of a LIM-domain protein assembly factor in mammalian ciliogenesis.
Bidirectional and reversible tuning of the interlayer spacing of two-dimensional materials
Authors: Ding Yiran , Zeng Mengqi , Zheng Qijing , Zhang Jiaqian , Xu Ding , Chen Weiyin , Wang Chenyang , Chen Shulin , Xie Yingying , Ding Yu , Zheng Shuting , Zhao Jin , Gao Peng , Fu Lei 
Published: October 2021

AbstractInterlayer spacing is expected to influence the properties of multilayer two-dimensional (2D) materials. However, the ability to non-destructively regulate the interlayer spacing bidirectionally and reversibly is challenging. Here we report the preparation of 2D materials with tunable interlayer spacing by introducing active sites (Ce ions) in 2D materials to capture and immobilize Pt single atoms. The strong chemical interaction between active sites and Pt atoms contributes to the intercalation behavior of Pt atoms in the interlayer of 2D materials and further promotes the formation of chemical bonding between Pt atom and host materials. Taking cerium-embedded molybdenum disulfide (MoS2) as an example, intercalation of Pt atoms enables interlayer distance tuning via an electrochemical protocol, leading to interlayer spacing reversible and linear compression and expansion from 6.546 ± 0.039 Å to 5.792 ± 0.038 Å (~11 %). The electronic property evolution with the interlayer spacing variation is demonstrated by the photoluminescence (PL) spectra, delivering that the well-defined barrier between the multilayer and monolayer layered materials can be artificially designed.
Biofilms can act as plasmid reserves in the absence of plasmid specific selection
Authors: Røder Henriette Lyng , Trivedi Urvish , Russel Jakob , Kragh Kasper Nørskov , Herschend Jakob , Thalsø-Madsen Ida , Tolker-Nielsen Tim , Bjarnsholt Thomas , Burmølle Mette , Madsen Jonas Stenløkke 
Published: October 2021

AbstractPlasmids facilitate rapid bacterial adaptation by shuttling a wide variety of beneficial traits across microbial communities. However, under non-selective conditions, maintaining a plasmid can be costly to the host cell. Nonetheless, plasmids are ubiquitous in nature where bacteria adopt their dominant mode of life - biofilms. Here, we demonstrate that biofilms can act as spatiotemporal reserves for plasmids, allowing them to persist even under non-selective conditions. However, under these conditions, spatial stratification of plasmid-carrying cells may promote the dispersal of cells without plasmids, and biofilms may thus act as plasmid sinks.
Comparing crystal structures with symmetry and geometry
Authors: Thomas John C. , Natarajan Anirudh Raju , Van der Ven Anton 
Published: October 2021

AbstractMeasuring the similarity between two arbitrary crystal structures is a common challenge in crystallography and materials science. Although there are an infinite number of ways to mathematically relate two crystal structures, only a few are physically meaningful. Here we introduce both a geometry-based and a symmetry-adapted similarity metric to compare crystal structures. Using crystal symmetry and combinatorial optimization we describe an algorithm to arrive at the structural relationship that minimizes these similarity metrics across all possible maps between any pair of crystal structures. The approach makes it possible to (i) identify pairs of crystal structures that are identical, (ii) quantitatively measure the similarity between crystal structures, and (iii) find and rank structural transformation pathways between any pair of crystal structures. We discuss the advantages of using the symmetry-adapted cost metric over the geometric cost. Finally, we show that all known structural transformation pathways between common crystal structures are recovered with the mapping algorithm. The methodology presented in this study will be of value to efforts that seek to catalogue crystal structures, identify structural transformation pathways or prune large first-principles datasets used to parameterize on-lattice Hamiltonians.
Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma
Authors: Halle Mari K. , Sundaresan Aishwarya , Zhang Jianqing , Pedamallu Chandra Sekhar , Srinivasasainagendra Vinodh , Blair Jessica , Brooke Dewey , Bertelsen Bjørn I. , Woie Kathrine , Shrestha Sadeep , Tiwari Hemant , Wong Yick Fu , Krakstad Camilla , Ojesina Akinyemi I. 
Published: October 2021

AbstractDespite recent advances in the prevention of cervical cancer, the disease remains a leading cause of cancer-related deaths in women worldwide. By applying the GISTIC2.0 and/or the MutSig2CV algorithms on 430 whole-exome-sequenced cervical carcinomas, we identified previously unreported significantly mutated genes (SMGs) (including MSN, GPX1, SPRED3, FAS, and KRT8), amplifications (including NFIA, GNL1, TGIF1, and WDR87) and deletions (including MIR562, PVRL1, and NTM). Subset analyses of 327 squamous cell carcinomas and 86 non-squamous cell carcinomas revealed previously unreported SMGs in BAP1 and IL28A, respectively. Distinctive copy number alterations related to tumors predominantly enriched for *CpG- and Tp*C mutations were observed. CD274, GRB2, KRAS, and EGFR were uniquely significantly amplified within the Tp*C-enriched tumors. A high frequency of aberrations within DNA damage repair and chromatin remodeling genes were detected. Facilitated by the large sample size derived from combining multiple datasets, this study reveals potential targets and prognostic markers for cervical cancer.
Impact of baseline clinical features on outcomes of nebulized glycopyrrolate therapy in COPD
Authors: Tashkin Donald P. , Niu Xiaoli , Sharma Sanjay , Sanjar Shahin 
Published: October 2021

AbstractInhaled bronchodilators are central for the treatment of chronic obstructive pulmonary disease (COPD), as they can provide symptom relief and reduce the frequency and severity of exacerbations while improving health status and exercise tolerance. In 2017, glycopyrrolate (GLY) delivered via the eFlow® closed system (CS) nebulizer (nebulized GLY; 25 µg twice daily), was approved by the US Food and Drug Administration for maintenance treatment of moderate-to-very-severe COPD. This approval was based largely on results from the replicate, placebo-controlled, Phase III clinical trials- GOLDEN 3 and 4. In this review, we summarize key findings from secondary analyses of the GOLDEN 3 and 4 studies, and provide a comprehensive overview that may assist both pulmonologists and primary-care providers in their treatment decisions. Comorbidities are common among patients with COPD in clinical practice and may impact bronchodilator efficacy. This review highlights outcomes among subpopulations of patients with comorbidities (e.g., anxiety/depression, cardiovascular disease), and their impact on the efficacy of nebulized GLY. In addition, the efficacy and safety of nebulized GLY across various demographics (e.g., age, gender) and baseline disease characteristics (e.g., disease severity, rescue medication use) are discussed. Real-world outcomes with nebulized GLY, including device satisfaction, healthcare resource utilization, and exacerbations, are also presented. These secondary analyses and real-world data complement the primary results with nebulized GLY from Phase III studies and support the need for the inclusion of patients representative of real-world clinical practice in RCTs. In addition, these data suggest that RCTs for COPD therapies should be complemented with real-world observational studies.
High-temperature superconductivity and its robustness against magnetic polarization in monolayer FeSe on EuTiO3
Authors: Liu Chong , Shin Hyungki , Doll Andrin , Kung Hsiang-Hsi , Day Ryan P. , Davidson Bruce A. , Dreiser Jan , Levy Giorgio , Damascelli Andrea , Piamonteze Cinthia , Zou Ke 
Published: October 2021

AbstractSpin degree of freedom generally plays an important role in unconventional superconductivity. In many of the iron-based compounds, superconductivity is found in close proximity to long-range antiferromagnetic order, whereas monolayer FeSe grown on SrTiO3, with enhanced superconductivity, exhibits no magnetic or nematic ordering. Here we grow monolayer and multilayer FeSe on antiferromagnetic EuTiO3(001) layers, in an effort to introduce a spin polarization in proximity to the superconductivity of FeSe. By X-ray magnetic dichroism, we observe an antiferromagnet–ferromagnet switching on Eu and Ti sites in EuTiO3 driven by the applied magnetic field, with no concomitant spin polarization on the Fe site of FeSe. Transport measurements show enhanced superconductivity of monolayer FeSe on EuTiO3 with a transition temperature of ~30 K. The band structure revealed by photoemission spectroscopy is analogous to that of FeSe/SrTiO3. Our work creates a platform for the interplay of spin and unconventional superconductivity in the two-dimensional limit.
Nematicity in a cuprate superconductor revealed by angle-resolved photoemission spectroscopy under uniaxial strain
Authors: Nakata S. , Horio M. , Koshiishi K. , Hagiwara K. , Lin C. , Suzuki M. , Ideta S. , Tanaka K. , Song D. , Yoshida Y. , Eisaki H. , Fujimori A. 
Published: October 2021

AbstractThe nature of the pseudogap and its relationship with superconductivity are one of the central issues of cuprate superconductors. Recently, a possible scenario has been proposed that the pseudogap state is a distinct phase characterized by spontaneous rotational symmetry breaking called “nematicity” based on transport and magnetic susceptibility measurements, where the symmetry breaking was observed below the pseudogap temperature T∗. Here, we report a temperature-dependent ARPES study of nematicity in slightly overdoped Bi1.7Pb0.5Sr1.9CaCu2O8+δ triggered by a uniaxial strain applied along one of the Cu–O bond directions. While the nematicity was enhanced in the pseudogap state as in the previous studies, it was suppressed in the superconducting state. These results indicate that the pseudogap state is characterized by spontaneous rotational symmetry breaking and that the nematicity may compete with superconductivity. Relationship between the nematicity and charge-density waves, both of which are observed in the pseudogap state, is discussed.