bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryptanalysis of Modular Exponentiation Outsourcing Protocols
Authors: Bouillaguet Charles , Martinez Florette , Vergnaud Damien 
Published: April 2021

Abstract
Public-key cryptographic primitives are time consuming for resource-constrained devices. A classical problem is to securely offload group exponentiations from a (comparatively) weak device—the client—to an untrusted more powerful device—the server. A delegation protocol must usually meet two security objectives: privacy—the exponent or the base should not be revealed to a passive adversary—and verifiability—a malicious server should not be able to make the client accept an invalid value as the result of the delegated computation. Most proposed protocols relies on a secret splitting of the exponent and the base, and a considerable amount of literature has been devoted to their analysis. Recently, Su et al. (Su, Q., Zhang, R. and Xue, R. (2020) Secure outsourcing algorithms for composite modular exponentiation based on single untrusted cloud. Comput. J., 63, 1271.) and Rangasamy and Kuppusamy (Rangasamy, J. and Kuppusamy, L. (2018) Revisiting Single-Server Algorithms for Outsourcing Modular Exponentiation. In Chakraborty, D. and Iwata, T. (eds), Progress in Cryptology - INDOCRYPT 2018: 19th International Conference in Cryptology in India, New Delhi, India, December 912, Vol. 11356, Lecture Notes in Computer Science. Springer, Heidelberg, Germany, pp. 320. proposed outsourcing protocols for modular exponentiations. They claim that their protocols achieve security (privacy and verifiability). We show that these claims are flawed and that their schemes are broken beyond repair. They remain insecure even if one increases significantly the proposed parameters (and consequently the protocols computational and communication complexities). Our attacks rely on standard lattice-based cryptanalytic techniques, namely the Coppersmith methods to find small integer zeroes of modular multivariate polynomials and simultaneous Diophantine approximation methods for the so-called approximate greatest common divisor problem.
Salvage radiotherapy for postoperative locoregional failure in esophageal cancer: a systematic review and meta-analysis
Authors: Mummudi N , Jiwnani S , Niyogi D , Srinivasan S , Ghosh-Laskar S , Tibdewal A , Rane P , Karimundackal G , Pramesh C S , Agarwal J P 
Published: April 2021

Summary
Locoregional recurrences following surgery for esophageal cancers represent a significant clinical problem with no standard recommendations for management. We conducted this systematic review and meta-analysis with the objective of studying safety and efficacy of salvage radiotherapy in this setting. All prospective and retrospective cohort studies, which studied patients who developed locoregional recurrence following initial radical surgery for esophageal cancer and subsequently received salvage radiation therapy (RT)/chemoradiation with all relevant information regarding survival outcome and toxicity available, were included. The quality of eligible individual studies was assessed using the Newcastle-Ottawa Scale score for risk of bias. R package MetaSurv was used to obtain a summary survival curve from survival probabilities and numbers of at-risk patients collected at various time points and to test the overall heterogeneity using the I2 statistic. Thirty studies (27 retrospective, 3 prospective) published from 1995 to 2020 with 1553 patients were included. The median interval between surgery and disease recurrence was 12.5 months. The median radiation dose used was 60 Gy and 57% received concurrent chemotherapy. The overall incidence of acute grade 3/4 mucositis and dermatitis were 8 and 4%, respectively; grade 3/4 acute pneumonitis was reported in 5%. The overall median follow-up of all studies included was 27 months. The 1-, 2- and 3-year overall survival (OS) probabilities were 67.9, 35.9 and 30.6%, respectively. Factors which predicted better survival on multivariate analysis were good PS, lower group stage, node negativity at index surgery, longer disease-free interval, nodal recurrence (as compared to anastomotic site recurrence), smaller disease volume, single site of recurrence, RT dose &gt;50 Gy, conformal RT, use of concomitant chemotherapy and good radiological response after radiotherapy. Salvage radiotherapy with or without concomitant chemotherapy for locoregional recurrences after surgery for esophageal cancer is safe and effective. Modern radiotherapy techniques may improve outcomes and reduce treatment-related morbidity.
Remote monitoring of patients with heart failure during the first national lockdown for COVID-19 in France
Authors: Ploux Sylvain , Strik Marc , Abu-Alrub Saer , Ramirez F Daniel , Buliard Samuel , Marchand Hugo , Picard François , Eschalier Romain , Haïssaguerre Michel , Bordachar Pierre 
Published: April 2021

Abstract

Aims
Multiparametric remote monitoring of patients with heart failure (HF) has the potential to mitigate the health risks of lockdowns for COVID-19. We aimed to compare healthcare use, physiological variables, and HF decompensations during 1 month before and during the first month of the first French national lockdown for COVID-19 among patients undergoing remote monitoring.

Methods and results
Transmitted vital parameters and data from cardiac implantable electronic devices were analysed in 51 patients. Medical contact was defined as the sum of visits and days of hospitalization. The lockdown was associated with a marked decrease in cardiology medical contact (118 days before vs. 26 days during, −77%, P = 0.003) and overall medical contact (180 days before vs. 79 days during, −58%, P = 0.005). Patient adherence with remote monitoring was 84 ± 21% before and 87 ± 19% during lockdown. The lockdown was not associated with significant changes in various parameters, including physical activity (2 ± 1 to 2 ± 1 h/day), weight (83 ± 16 to 83 ± 16 kg), systolic blood pressure (121 ± 19 to 121 ± 18 mmHg), heart rate (68 ± 10 to 67 ± 10 b.p.m.), heart rate variability (89 ± 44 to 78 ± 46 ms, P = 0.05), atrial fibrillation burden (84 ± 146 vs. 86 ± 146 h/month), or thoracic impedance (66 ± 8 to 66 ± 9 Ω). Seven cases of HF decompensations were observed before lockdown, all but one of which required hospitalization, vs. six during lockdown, all but one of which were managed remotely.

Conclusions
The lockdown restrictions caused a marked decrease in healthcare use but no significant change in the clinical status of HF patients under multiparametric remote monitoring.
Credit Misallocation During the European Financial Crisis
Authors: Schivardi Fabiano , Sette Enrico , Tabellini Guido 
Published: April 2021

Abstract
Using data on bank-firm relationships in Italy during the Eurozone financial crisis, we show that: (i) compared to healthy banks, under-capitalised banks cut credit to healthy but not to zombie firms and are more likely to prolong a credit relationship with a zombie; (ii) in area sectors with more low-capital banks, zombies are more likely to survive; (iii) bank under-capitalisation does not hurt the growth rate of healthy firms. We provide evidence that extending credit to the weakest firms during the recession mitigated the disruption of supply chains and adverse local demand externalities.
Public awareness of the association between human papillomavirus and oropharyngeal cancer
Authors: Verhees Femke , Demers Imke , Schouten Leo J , Lechner Matt , Speel Ernst-Jan M , Kremer Bernd 
Published: April 2021

Abstract

Background
Early diagnosis of human papillomavirus (HPV) associated oropharyngeal cancer (OPC) is associated with improved survival. To achieve early diagnosis, it might be beneficial to increase awareness of the link between HPV and OPC. This increase of awareness could also be an important way to increase vaccination rates. The aim of our study was to explore the current public knowledge in the Netherlands regarding the association of HPV with OPC.

Methods
An online cross-sectional survey was used and sent by the company Flycatcher Internet Research to 1539 of their panel members. Data were analyzed statistically by gender, age, educational level and the participants’ use of alcohol and tobacco.

Results
The response rate was 68% (1044 participants). Our data revealed that 30.6% of the participants had heard of HPV. There was a knowledge gap regarding HPV in males (P &lt; 0.001), people older than 65 years (P &lt; 0.001), people with low education level (P &lt; 0.001) and current smokers (P &lt; 0.001). Of the respondents who had heard of HPV, only 29.2% knew of the association between HPV and OPC. We also found that only 49.7% of the population knew of the existence of an HPV vaccine.

Conclusions
The results of this survey indicate that the public awareness of HPV and the association of HPV with OPC is lacking. Interventions to increase awareness of HPV and its association with non-cervical cancer should be considered. This might help to increase the HPV vaccine uptake both for girls and boys and earlier diagnosis of this disease leading to improved survival.
Primary care provider expectations of addiction services and patients in Spain
Authors: Andreu Magalí , Alcaraz Noelia , Gual Antoni , Segura Lidia , Barrio Pablo 
Published: April 2021

Abstract

Background
Primary care (PC) is crucial in the care of substance use disorder (SUD) patients. However, the relationship between PC and addiction settings is complex and collaboration issues stand out. Available evidence suggests that integration of SUD and PC services can improve physical and mental health of SUD patients and reduce health expenses.

Objective
To explore the experiences, views and attitudes of PC professionals towards the interaction between PC and SUD services.

Methods
Twenty-seven GPs took part in three focus groups. The focus group sessions were audio-taped, transcribed verbatim and analysed using reflexive thematic analysis. Recurrent themes were identified.

Results
Four main themes were devised: (1) Differences and specificities of SUD patients, (2) Interaction between providers of PC and addiction services, (3) Patient management (4) Addiction stigma. These main themes reflect the consideration that SUD patients are a specific group with specific care needs that yield specific challenges to GPs themselves. Improved training, availability of a shared medical record system, increased feedback between GP and addiction specialists and the efficiency of the circuit are to be considered the main priority for the majority of the participants.

Conclusions
An efficient and effective referral circuit, with increased feedback and shared medical records is considered key to GPs. Its implementation should keep in mind the specific features of both SUD patients and GPs
The growing repertoire of genetic tools for dissecting chlamydial pathogenesis
Authors: Banerjee Arkaprabha , Nelson David E 
Published: April 2021

ABSTRACT
Multiple species of obligate intracellular bacteria in the genus Chlamydia are important veterinary and/or human pathogens. These pathogens all share similar biphasic developmental cycles and transition between intracellular vegetative reticulate bodies and infectious elementary forms, but vary substantially in their host preferences and pathogenic potential. A lack of tools for genetic engineering of these organisms has long been an impediment to the study of their biology and pathogenesis. However, the refinement of approaches developed in C. trachomatis over the last 10 years, and adaptation of some of these approaches to other Chlamydia spp. in just the last few years, has opened exciting new possibilities for studying this ubiquitous group of important pathogens.
Acetylcholine signaling genes are required for cocaine-stimulated egg laying in Caenorhabditis elegans
Authors: Emerson Soren , Hay Megan , Smith Mark , Granger Ricky , Blauch David , Snyder Nicole , El Bejjani Rachid 
Published: April 2021

Abstract
The toxicity and addictive liability associated with cocaine abuse are well-known. However, its mode of action is not completely understood, and effective pharmacotherapeutic interventions remain elusive. The cholinergic effects of cocaine on acetylcholine receptors, synthetic enzymes, and degradative enzymes have been the focus of relatively little empirical investigation. Due to its genetic tractability and anatomical simplicity, the egg laying circuit of the hermaphroditic nematode, Caenorhabditis elegans, is a powerful model system to precisely examine the genetic and molecular targets of cocaine in vivo. Here, we report a novel cocaine-induced behavioral phenotype in C. elegans, cocaine-stimulated egg laying. In addition, we present the results of an in vivo candidate suppression screen of synthetic enzymes, receptors, degradative enzymes, and downstream components of the intracellular signaling cascades of the main neurotransmitter systems that control C. elegans egg laying. Our results show that cocaine-stimulated egg laying is dependent on acetylcholine synthesis and synaptic release, functional nicotinic acetylcholine receptors, and the C. elegans acetylcholinesterases.
The Wild Worm Codon Adapter: a web tool for automated codon adaptation of transgenes for expression in non-Caenorhabditis nematodes
Authors: Bryant Astra S , Hallem Elissa A 
Published: April 2021

Abstract
Advances in genomics techniques are expanding the range of nematode species that are amenable to transgenesis. Due to divergent codon usage biases across species, codon optimization is often a critical step for the successful expression of exogenous transgenes in nematodes. Platforms for generating DNA sequences codon-optimized for the free-living model nematode Caenorhabditis elegans are broadly available. However, until now such tools did not exist for non-Caenorhabditis nematodes. We therefore developed the Wild Worm Codon Adapter, a tool for rapid transgene codon optimization for expression in non-Caenorhabditis nematodes. The app includes built-in optimization for parasitic nematodes in the Strongyloides, Nippostrongylus, and Brugia genera as well as the predatory nematode Pristionchus pacificus. The app also supports custom optimization for any species using user-provided optimization rules. In addition, the app supports automated insertion of synthetic or native introns, as well as the analysis of codon bias in transgene and native sequences. Here, we describe this web-based tool and demonstrate how it may be used to analyze genome-wide codon bias in Strongyloides species.
Read between the Lines: Diversity of Nontranslational Selection Pressures on Local Codon Usage
Authors: Callens Martijn , Pradier Léa , Finnegan Michael , Rose Caroline , Bedhomme Stéphanie 
Published: April 2021

Abstract
Protein coding genes can contain specific motifs within their nucleotide sequence that function as a signal for various biological pathways. The presence of such sequence motifs within a gene can have beneficial or detrimental effects on the phenotype and fitness of an organism, and this can lead to the enrichment or avoidance of this sequence motif. The degeneracy of the genetic code allows for the existence of alternative synonymous sequences that exclude or include these motifs, while keeping the encoded amino acid sequence intact. This implies that locally, there can be a selective pressure for preferentially using a codon over its synonymous alternative in order to avoid or enrich a specific sequence motif. This selective pressure could—in addition to mutation, drift and selection for translation efficiency and accuracy—contribute to shape the codon usage bias. In this review, we discuss patterns of avoidance of (or enrichment for) the various biological signals contained in specific nucleotide sequence motifs: transcription and translation initiation and termination signals, mRNA maturation signals, and antiviral immune system targets. Experimental data on the phenotypic or fitness effects of synonymous mutations in these sequence motifs confirm that they can be targets of local selection pressures on codon usage. We also formulate the hypothesis that transposable elements could have a similar impact on codon usage through their preferred integration sequences. Overall, selection on codon usage appears to be a combination of a global selection pressure imposed by the translation machinery, and a patchwork of local selection pressures related to biological signals contained in specific sequence motifs.
COVID-19, Time to Oneself, and Loneliness: Creativity as a Resource
Authors: Pauly Theresa , Chu Li , Zambrano Elizabeth , Gerstorf Denis , Hoppmann Christiane A 
Published: April 2021

Abstract

Objectives
Physical distancing to reduce the spread of the coronavirus disease 2019 has increased alone time, with unintended mental health ramifications including increased loneliness, which may be particularly detrimental for older adults. We investigated time-varying associations between daily time to oneself and loneliness, and the role of everyday creativity as a resource.

Method
126 adults aged 18–84 completed online questionnaires including a 10-day daily diary module, during which they self-reported alone time, everyday creativity, and loneliness. Data were analyzed using multilevel models, controlling for study day, participation date, gender, and relationship status.

Results
Greater average amounts of alone time were associated with greater loneliness, an association that was stronger in old age. In a daily context, individuals reported feeling lonelier on days when they had more time to themselves than usual. This within-person association was weaker with older age. Everyday creativity did not moderate alone time–loneliness associations. However, holding time to oneself constant, participants felt less lonely and less bothered by alone time on days when they were more creative than usual.

Discussion
Participating in creative behaviors (e.g., pursuing arts and crafts) might be linked with reduced loneliness. Intervention studies are needed to investigate whether fostering creativity could help promote mental well-being in times when people, especially older adults, are vulnerable to loneliness and associated health risks.
Psychological Connection to the Gay Community and Negative Self-Appraisals in Middle-Aged and Older Men Who Have Sex With Men: The Mediating Effects of Fitness Engagement
Authors: Brennan-Ing Mark , Haberlen Sabina , Ware Deanna , Egan James E , Brown Andre L , Meanley Steven , Palella Frank J , Bolan Robert , Cook Judith A , Okafor Chukwuemeka N , Friedman M Reuel , Plankey Michael W 
Published: April 2021

Abstract

Objectives
Connections to the gay community may elicit negative self-appraisals among men who have sex with men (MSM), which may be exacerbated for people with HIV (PWH). Fitness engagement may mediate self-appraisals by maintaining or improving appearance and health. We hypothesized that gay community connections would be positively related to negative self-appraisal and explored whether this association would be mediated by fitness engagement and moderated by HIV status.

Method
Data were obtained from the Multicenter AIDS Cohort Healthy Aging study (N = 1,026; PWH n = 525; people without HIV [PWOH] n = 501). Structural equation modeling (SEM) examined associations between gay community connections, negative self-appraisal (body image dissatisfaction, self-perception of aging), and fitness engagement (physical activity, motivation to be fit). Multiple-group SEM tested the moderating effects of HIV serostatus.

Results
The SEM fit the data well (root mean square error of approximation = 0.056; 90% CI: 0.046, 0.066). Connection to the gay community was inversely related to negative self-appraisals and positively related to fitness engagement. Fitness engagement mediated the association between community connections and negative self-appraisal and was inversely related to negative self-appraisals. Among PWH, the association between community connections and self-appraisal was weaker and the effect of fitness engagement on negative self-appraisal was stronger compared to PWOH.

Discussion
Connection to the gay community may be a source of resilience for aging MSM by lessening negative self-appraisals and promoting strategies that address body image dissatisfaction and self-perceptions of aging. Interventions facilitating connections to the gay community may support healthy aging in this population.
Empowering communities with health promotion labs: result from a CBPR programme in Malmö, Sweden
Authors: Avery Helen , Sjögren Forss Katarina , Rämgård Margareta 
Published: April 2021

SummaryHealth promotion is thus not only a participatory practice, but a practice for empowerment and social justice. The study describes findings from a community-based participatory and challenge-driven research program. that aimed to improve health through health promotion platform in an ethnically diverse low-income neighbourhood of Malmö, Sweden. Local residents together with lay health promoters living in the area were actively involved in the planning phase and decided on the structure and content of the program. Academic, public sector and commercial actors were involved, as well as NGOs and residents. Empowerment was used as a lens to analyse focus group interviews with participants (n=322) in six co-creative health-promoting labs on three occasions in the period 2017-2019. The CBPR interview guide focused on the dimensions of participation, collaboration and experience of the activities. The CBPR approach driven by community member contributed to empowerment processes within the health promotion labs: Health promotors building trust in social places for integration, Participants motivate each other by social support and Participants acting for community health in wider circle. CBPR Health promotion program should be followed up longitudielly with community participants to be able to see the processes of change and empowerment on the community level.
Xenophobia in the Time of a Pandemic: Social Media Use, Stereotypes, and Prejudice against Immigrants during the COVID-19 Crisis
Authors: Ahmed Saifuddin , Chen Vivian Hsueh Hua , Chib Arul Indrasen 
Published: April 2021

Abstract
This study examines the relationship between social media use, disease risk perception, social and political trust, and out-group stereotyping and prejudice during a social upheaval. Analyses of primary data collected during the COVID-19 outbreak in Singapore found that disease risk perception is positively related to stereotyping and prejudice against Chinese immigrants. Individuals who used social media for news were more likely to stereotype and express prejudice. However, those who engaged in frequent heterogenous discussions, and had more extensive social networks, were less likely to stereotype and express prejudice. Higher social and political trust was also associated with lower stereotyping and prejudice. Finally, moderation effects of network characteristics on the relationship between risk perception, social trust, and prejudice were observed.