bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous coronary artery dissection: an Italian single centre experience
Authors: Solinas Emilia , Alabrese Renato , Cattabiani Maria Alberta , Grassi Francesca , Pelà Giovanna Maria , Benatti Giorgio , Tadonio Iacopo , Toselli Marco , Ardissino Diego , Vignali Luigi 
Published: September 2021

Aims
Spontaneous coronary artery dissection (SCAD) is an emerging cause of acute myocardial infarction (AMI) in young women without a typical cardiovascular risk profile. Knowledge on SCAD is based on observational studies and is still scarce. The aim of this monocentric observational study was to evaluate the predisposing factors, clinical features and prognosis of SCAD patients.

Methods
Between 2013 and 2020, 58 patients with angiographic diagnosis of SCAD were identified in our centre with an overall prevalence of 0.9% among patients admitted for AMI (58 of 6414 patients).

Results
The mean age was 54 ± 11 years and the majority were women (n = 50, 86%) with one or fewer cardiovascular risk factors (n = 35, 60%). The prevalence of Fibromuscolar Dysplasia (FMD) was 39% (7 of 18 screened patients). The rate of major adverse cardiovascular and cerebrovascular events (MACCEs) was used to assess the prognosis. Out-of-hospital cardiac arrest because of ventricular fibrillation was observed in four (7%) patients. The majority of patients (n = 51, 88%) were treated conservatively without revascularization. The in-hospital and 30-day clinical course was uneventful in most patients (n = 54, 93%) with two cardiac deaths. During a median follow-up of 12 months, there were no further deaths. The global rate of SCAD recurrence was significant (n = 8, 14%) but predictors have not been identified.

Conclusion
Although overall survival seems good, SCAD is a potentially malignant, not rare disease, which can present with sudden cardiac death and not uncommon recurrence. Prognostic stratification and optimal management of SCAD patients remain to be defined.
ECG evaluation in 11 949 Italian teenagers: results of screening in secondary school
Authors: Mancone Massimo , Maestrini Viviana , Fusto Antonio , Adamo Francesco , Scarparo Paola , D’Ambrosi Alessandra , Cinque Alessandra , Gatto Maria Chiara , Salvi Nicolò , Agnes Gianluca , Pucci Mariateresa , Birtolo Lucia Ilaria , Marruncheddu Laura , Genuini Igino , De Lazzari Claudio , Severino Paolo , Giunta Giuseppe , Lavalle Carlo , Fegatelli Danilo Alunni , Vestri Annarita , Fedele Francesco 
Published: September 2021

Aim
There is lack of evidence regarding the screening role of ECG for sudden cardiac death (SCD) prevention. Our aim was to evaluate the prevalence of ECG abnormalities among teenagers according to sport participation and competitive status.

Methods
Eleven thousand nine hundred and forty-nine Italian pupils from 179 secondary schools (13–19 years) were consecutively enrolled. ECG abnormalities were divided into minor and major. Medical history, clinical examination and sport activity information were acquired. Further evaluations were suggested in case of major ECG abnormalities. Follow-up was performed at 2 years.

Results

N = 1945 (16%) pupils had ECG abnormalities. Major ECG abnormalities were detected in 13% of the cohort, minor in 34%. ECG abnormalities were more common in nonathletes compared with athletes. A diagnosis of cardiac disease was reached in 25 (1.6%) of the pupils with major ECG abnormalities.

Conclusion
ECG abnormalities are common among young populations and more prevalent in nonathletes. Among pupils with major ECG abnormalities 1.6% had a cardiac disease diagnosis. Our results are in line with the data supporting ECG screening in the general young population.
Development of a Testing Station for Empirical Verification of the Algebraic Model of Dry Ice Piston Extrusion
Authors: Górecki Jan 
Published: September 2021

Abstract
Efficient use of resources is a very important consideration for every production process, especially where waste materials are used as raw materials. One example of these kinds of processes is dry ice extrusion. Based on the subject literature, it can be observed that the machines available in the market that are used to compress dry ice are characterized by high working force value. This leads to low efficiency of resource consumption, in regards to both electrical energy and carbon dioxide. This paper presents a proposed design of a test stand used for measuring compression force as a function of piston displacement in the course of the dry ice extrusion. The first part of the article presents the testing methodology and test stand design. The second part presents the results of measurement of compression force as a function of piston displacement with three different die types. The results of the study allowed to establish the difference between the values of the measured limit force and the values calculated with an analytical model. The test stand design and the results presented in this paper are important for further research and development works in the area of efficient extrusion and compaction of dry ice.
Biochemical composition and shape-dimensional traits of rosehip genotypes
Authors: Demir Bünyamin , Sayıncı Bahadır , Yaman Mehmet , Sümbül Ahmet , Yıldız Ercan , Karakaya Orhan , Alkaya Günseli Bobuş , Ercişli Sezai 
Published: September 2021

Abstract
In the present study, the biochemical composition and shape and dimensional traits of 25 rosehip (Rosa canina) genotypes were investigated. The shape and dimensional traits were determined by image processing technique. Seed-propagated rosehip genotypes belonging to R. canina were collected from the natural flora of Mesudiye (Ordu) and Talas (Kayseri) districts. Antioxidant activity (39.510–72.673 mmol · kg−1), total flavonoids (287.80–1,686.20 mg quercetin equivalent (QE) · kg−1) and total phenolics (38,519.40–79,080.60 mg gallic acid equivalent · kg−1) of the genotypes exhibited large variations. Width (12.2 mm) and thickness (12.5 mm) of fruits averages were found to be close to each other. The genotypes exhibited fruit lengths between 12.0 mm and 29.5 mm. Average projected area at horizontal orientation (179.7 mm2) was greater than the projected area at vertical orientation (120.4 mm2). Sphericity average was calculated as 71.4%. According to principal component (PC) analysis, the most important dimensional traits discriminating genotypes from each other were identified as surface area, geometric mean diameter and volume. In terms of shape attributes, distinctive differences were observed in sphericity, circularity, elongation and surface closure rates (SCR) of the genotypes. According to elliptic Fourier analysis (EFA), genotypes look like a sphere. In terms of shape, there were long, spherical, flat bottomed, pointed bottomed and asymmetric-looking genotypes indicating how environment and genotype affect the fruit shape. The greatest shape variation was transverse contraction and expansion. According to the clustering analysis for shape attributes, rosehip genotypes were classified into six groups. Dendrogram, scatter plots of linear discriminant analysis and paired comparison test results put forth the shape differences of the genotype successfully.
The Synthetic Performances of Teochew
Authors: Luo Zhuosi 
Published: September 2021

Abstract
Huang (2015) characterizes “Modern Chinese as a language of high analyticity at multiple levels” and demonstrates “a ranking of relative analyticity among the three dialects: Cantonese > Mandarin > TSM”. This paper argues that Teochew (cháoshànhuà, 潮汕話), another variety of Min, different from TSM, shows more synthetic performances than Mandarin. Chomsky’s “productivity” criterion (1970) helps distinguish lexical operations from syntactic ones. In this spirit, this paper will illustrate its arguments from two perspectives -- lexical and syntactic operations. When it comes to lexical operations, analyses on both the semantic changes within the same categories and the categorial shifts will be made. Besides, syntactic discussions on emphatic inflection, bare classifier phrases, verb-object order and other variants of V-movements in Teochew will also be demonstrated. All analyses will be put under the theoretical framework of generative grammar with the help of a cartography approach. For analyses at the lexical layer, this paper adopts Si’s 司富珍 (2012, 2017a, 2017b, 2018) XW structure, trying to capture the synthesis performances of the Teochew lexicon. As for syntactic operations, the split-CP hypothesis of Rizzi (1997, 2001, 2004) and Rizzi and Bocci (2015), the CL-to-D hypothesis of Simpson (2005), the light verb approach of Chomsky (1995) and the split-light verb hypothesis of Si 司富珍 (2018) will be used as references. Through comparative studies with Mandarin, Cantonese and other languages like English, this paper will conclude that Teochew is a dialect with higher synthesis compared with Mandarin.
Pengaruh Pelapisan Gel Lidah Buaya dengan Campuran Asam Askorbat dan Kalium Sorbat terhadap Susut Bobot, pH dan Organoleptik Buah Melon Potong Segar
Authors: Sulasmi Ni Wayan , Utama I Made Supartha , Arthawan I Gusti Ketut Arya 
Published: September 2021

ABSTRAK
Buah melon yang telah mengalami pengolahan minimal memiliki sifat mudah rusak (perishable) dengan masa simpan yang relative singkat. Penelitian ini bertujuan untuk mengatahui pengaruh pelapisan gel lidah buaya dengan campuran asam askorbat dan kalium sorbat terhadap susut bobot, pH dan organoleptik buah melon potong segar atau proses minimal. Penelitian menggunakan Rancangan Acak Lengkap (RAL) terdiri dari dua faktor perlakuan yaitu konsentrasi asam askorbat (0%, 1.5% dan 3%) dan kalium sorbat (0%, 0.2% dan 0.4%). Percobaan ini diulang sebanyak tiga kali dengan suhu penyimpanan 5±2?C. Hasil penelitian menunjukkan asam askorbat dan kalium sorbat berpengaruh nyata terhadap nilai susut bobot, pH dan atribut organoleptik buah melon potong segar. Asam askorbat dan kalium sorbat mampu menghambat kehilangan bobot, mempertahankan nilai organoleptik dan menurunkan nilai pH sehingga aktivitas pertumbuhan jamur dan kapang terhambat pada buah potong tersebut. Gel lidah buaya dengan penambahan asam askorbat 3% dan kalium sorbat 0,2% merupakan perlakuan yang memberikan nilai atribut organoleptik terbaik selama penyimpanan. Kombinasi ini mampu mempertahankan nilai warna dan tekstur hingga hari ke 14 serta mempertahankan aroma hingga hari ke 10.
ABSTRACT
Melon fruit which is undergone a minimal process is easy to damage (perishable) with short shelf life. This study aims to determine the effect of coating aloe vera gel with a mixture of ascorbic acid and potassium sorbate on weight loss, pH, and organoleptic of fresh-cut melons. This study using a completely randomized design (CRD consisted of two treatment factors, namely ascorbic acid (0%, 1.5%, and 3%) and potassium sorbate (0%, 0.2% and 0.4%)). The experiment was replicated three times with a storage temperature of 5 ± 2?C. The results showed that ascorbic acid and potassium sorbate significantly affected the weight loss, pH, and organoleptic values ??of fresh-cut melons. Ascorbic acid and potassium sorbate can inhibit weight loss, maintain organoleptic values ??, and reduce the pH value of fresh-cut melons so that the activity of fungal and mold growth is inhibited. Aloe vera gel with the addition of 3% ascorbic acid and 0.2% potassium sorbate was the treatment that gave the best organoleptic value during storage. This combination can maintain the value of color and texture up to day 14 and maintain aroma until day 10.
Pengaruh Suhu dan Waktu Pengeringan terhadap Mutu Organoleptik Buah Naga Merah (Hylocereus polyrhizus) Semi Kering.
Authors: Santi Indri Novia , Utama I Made Supartha , Madrini Ida Ayu Gede Bintang 
Published: September 2021

ABSTRAK
Penelitian ini bertujuan untuk mengetahui pengaruh suhu dan waktu pengeringan terhadap mutu organoleptik buah naga merah (Hylocereus polyrhizus) semi kering, serta menemukan kombinasi terbaik dari kedua perlakuan tersebut. Penelitian dirancang dengan Rancangan Acak Lengkap dengan dua faktor yaitu suhu (40°C, 50°C dan 60°C) dan waktu (15 jam, 20 jam dan 25 jam) dengan tiga ulangan. Hasil penelitian menunjukkan bahwa perlakuan suhu dan waktu pengeringan berinteraksi dan secara sangat nyata berpengaruh terhadap mutu visual, tekstur, aroma, rasa dan penerimaan secara keseluruhan. Kombinasi terbaik adalah perlakuan suhu 60°C dan waktu pengeringan 20 jam dengan nilai organoleptik yaitu mutu visual 3.84 (suka), tekstur 3.96 (suka), aroma 3.69 (suka), rasa 4.04 (suka) dan penerimaan secara keseluruhan 4.24 (suka).
ABSTRACT
This study aims to determine the effect of temperature and drying time on the organoleptic quality of semi-dry red dragon fruit (Hylocereus polyrhizus) and to find the best combination of the two treatments. The study was designed with a completely randomized design with two factors, namely temperature (40°C, 50°C, and 60°C) and time (15, 20, and 25 hours) with three replications. The results showed that the treatment temperature and drying time interacted and significantly affected the visual quality, texture, aroma, taste, and overall acceptance. The best combination is a temperature treatment of 60°C and drying time of 20 hours with organoleptic values ??such as the visual quality value of 3.84 (favorable), texture value of 3.96 (favorable), aroma value of 3.69 (favorable), taste value of 4.04 (favorable) and overall acceptance of 4.24 (favorable).
Survival COVID-19 in Adult Patients with Liver Cirrhosis
Authors: Aprilicia Gita , Syarif Syahrizal , Kalista Kemal Fariz , Sulaiman Andri Sanityoso , Hasan Irsan , Lesmana Cosmas Rinaldi A , Kurniawan Juferdy , Jasirwan Chyntia Olivia Maurine , Nababan Saut Horas Hatoguan , Gani Rino Alvani 
Published: September 2021

Background: COVID-19 is a disease caused by infection of SARS-CoV-2 virus which leads to mortality due to respiratory failure. The progression of COVID-19 is more severe in patients with pre-existence morbidities, including liver disease. Recently, a few studie showed that liver cirrhosis patients with COVID-19 had a higher risk of mortality rather than liver cirrhosis patients without COVID-19 infection. Nevertheless, the study of survival COVID-19 in a patient with underlying liver cirrhosis is still limited. The aim of this study is to evaluate the survival of COVID-19 in adult patients with liver cirrhosisMethod: An observational study in Cipto Mangunkusumo Hospital was conducted. Patients with underlying liver cirrhosis between March 2020-January 2021 with positive confirmation of COVID-19 were enrolled in this study. Liver cirrhosis patients without COVID-19 were enrolled as a comparison. Both liver cirrhosis patients with and without COVID-19 were follow up at the time of hospital admission until 30 days outcome. Kaplan Meier and a log-rank test were conducted to evaluate the comparison of survival rate in liver cirrhosis patients with and without COVID-19. Multivariate Cox Proportional Hazard was conducted to identify the independent risk factors related to survival.Results: There were 22 liver cirrhosis patients with COVID-19 and 116 liver cirrhosis patients included in this study. Presentation of gender and age similar both of them. Predominantly males with average age were 57 years ± 13,60 for cirrhosis with COVID-19 patients and 53 years ± 12,75 for without COVID-19. The survival rate of liver cirrhosis patients with COVID-19 lower than liver cirrhosis patients without COVID-19 (35.8% vs. 67.2%, p-value 0.001). Median survival of liver cirrhosis patients with COVID-19 was 4 days (95% CI: 1-8 days), while median survival of liver cirrhosis patients without COVID-19 couldn’t be reached since the survival rate of this group above 50%. Final model Cox PH showed that liver cirrhosis with COVID-19 (HR: 8.99; CI 95%: 4.55 – 17.80, p-value 0.001) and Child-Pugh class C (HR: 5.61; 95% CI: 2.76 – 11.40, p-value 0.001) were the independent risk factors associated with poor survival.Conclusion: The survival rate of liver cirrhosis patients with COVID-19 lower than liver cirrhosis patients without COVID-19. Liver cirrhosis with COVID-19 and Child-Pugh class C were associated with poor survival.
Features of the retinal structual and functional state under cardiopylmonary bypass during cardiac surgery
Authors: Diakova M. L. , Podoksenov Yu.  K. , Shishneva E. V. , Denisk M. S. , Krylova A. A. , Krivosheina O. I. , Shipulin V. M. 
Published: September 2021

Introduction. Cardiac surgeries using cardiopylmonary bypass (CB) have been successfully performed for more than 60 years, but at present it is necessary to further study the changes in tissue hemodynamics during interventions to minimize possible iatrogenic complications. One of these tissues available for direct observation of the vessels of the microvasculature is the retina. Aim – to study the structural and functional state of the retina in patients who underwent cardiac surgery with the use of CB, and to identify potential factors that negatively affect the retinal blood flow. Materials and methods. The clinical study involved 10 patients (20 eyes). All patients before cardiac surgery using CB and 10–14 days after it underwent visometry, perimetry, non-contact tonometry, biomicroscopy, reverse binocular ophthalmoscopy, fundus photography, optical coherence tomography of the retina of the macular region and optic nerve head with determination of the thickness of the layer of ganglion cell and the layer of nerve fibers. To carry out CB, pharmaco-cold cardioplegia was performed with the Custodiol solution using unified surgical and anesthetic tactics. CB was performed on a device with disposable membrane oxygenators (Strockert, Germany) under normothermic conditions, blood circulation was provided with non-pulsating blood flow with a volumetric flow rate of 2.4–2.8 L/min/m2 at an initial dose of heparin of 300 U/kg. Results. The studies revealed a correlation between changes in the histoarchitectonics of the retina and the level of mean arterial pressure (MAP). So, in 30 % of patients, the appearance of ischemic foci along the vascular arcades was found. In 10 % of patients, a decrease in the thickness of the ganglion layer and the layer of retinal nerve fibers was reported as a result of impaired blood circulation in the vessels supplying the optic nerve. Conclusion. Increase in MAP up to 90 mm Hg and above and fluctuations in its level of more than 20 mm Hg (p<0.05) during cardiac surgery under cardiopulmonary bypass in 67 % of cases is accompanied by transient disturbance of regional blood circulation at the level of vessels of the microvasculature of the retina with the appearance of ischemic foci in the retinal tissue. In this regard, it is necessary to carefully monitor the MAP parameters during the cardiopulmonary bypass to prevent circulatory disorders in various organs and tissues of the body.
The role of soluble leptin receptor in the pathogenesis of coronary heart disease
Authors: Polyakova E. A. 
Published: September 2021

Introduction. The participation of soluble leptin receptor (SLR) in the formation of hyperleptinemia and leptin resistance in patients with coronary artery disease (CAD) in combination with obesity is discussed.Aim.Study of the role of SLR in the pathogenesis of ischemic heart disease.Materials and methods.A cohort study of 744 patients was performed: 465 patients with CAD (56 years old, Q1=44; Q3=62), 270 patients without CAD (52 years old, Q1=44; Q3=56). Methods: EchoCG, heart computed tomography, coronary angiography. In the blood serum, the lipids, glucose, creatinine, uric acid, and c-reactive protein were assessed using a highly sensitive method (HF-CRP). Concentrations of SLR, leptin (LN), adiponectin (total and high molecular weight), fatty acid binding protein-4 (FABP-4) tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), serum insulin were determined by enzyme immunoassay.Results.The level of SLR in blood serum in men and women with CAD is lower than in men without CAD (p <0.001). In CAD patients, obesity was associated with a low SLR level in the blood serum and a high free LN index. At a serum SLR concentration of <7.5ng/ml in men with CAD, the incidence of obesity was higher simultaneously with signs of visceral obesity of the heart, the presence of atherosclerotic plaques in the common carotid arteries, high glycaemic levels, insulin, IL-6, and LN in serum, serum LN/adiponectin ratio and a high HOMA-IR index. Diabetes mellitus, visceral obesity, high levels of hs-CRP, TNF-α, FABP-4, serum insulin, and HOMA-IR index were more often detected in women with coronary artery disease with SLR <10.2 ng/ml. In men and women with CAD, there were no differences in SLR concentration depending on the extent of coronary atherosclerosis.Conclusion.An increase in the free LN index indicates the disruption of connections in the leptin-receptor system and reflects the mechanisms of compensation for overcoming the resistance of peripheral tissues to leptin, which is confirmed by a noticeable negative relationship between the levels of SLR and leptin in the serum of men with coronary artery disease. A low concentration of SLR in patients with CAD is associated with obesity, pro-atherogenic and pro-inflammatory markers of cardiovascular diseases.
Sex-dependent change in the reactivity of isolated pulmonary arteries of gonadectomized rats under the intermittent hypoxia of different degree
Authors: Pankova N. V. , Artemieva M. M. , Medvedeva N. A. 
Published: September 2021

Introduction. Pulmonary vasoconstriction is one of factors of hypoxic pulmonary hypertension (HPH). The progression of this disease depends on the degree of hypoxiа and seх. The aim of this study was to investigate the reactivity of isolated pulmonary vessels of male and female rats with HPH to vasoactive factors. Materials and methods. The experiments were on male and female of Wistar rats 190–200 g, which were gonadectomized. All animals were divided into 4 groups. One group of males and female rats was kept in a vivarium (21 % О2 ). To simulate HPH, other rats were exposed to hypobaric hypoxia for 10 hours a day at an oxygen content in the inhaled air equal to 13 % (pP O2 103.7 mmHg) or 10 % (pP O2 78,2 mmHg), or 8 % (pP O2 63,5 mmHg) as compared to its content at 21 % (pP О2 159 mmHg). After that, a third-order pulmonary vessel was perfused at a constant flow rate with vasoconstrictors and vasodilators. The reaction was recorded by the change in perfusion pressure. Results. In females with HРН 10 %O2 , constricting response to serotonin were greater than in males. In normotensive males, the dilatory response to sodium nitroprusside (NP) was less than in female. Exposure to hypoxia induced an increase in NP responses. Conclusion. Increased reactivity of pulmonary vessels to serotonin is a factor of pathogenesis of HPH in females, in contrast to males. Increased reactivity to NO donor in males exposed to hypoxia сan be used for a pharmacological target for HPH.