bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of COVID-19 Lockdowns on the Usage of a Vision Assistance App Among Global Users With Visual Impairment: Big Data Analytics Study
Authors: Luo Gang , Pundlik Shrinivas 
Published: May 2021

Background
Millions of individuals with visual impairment use vision assistance apps to help with their daily activities. The most widely used vision assistance apps are magnifier apps. It is still largely unknown what the apps are used for. Lack of insight into the visual needs of individuals with visual impairment is a hurdle for the development of more effective assistive technologies.

Objective
This study aimed to investigate how needs for visual aids may vary with social activities, by observing the changes in the usage of a smartphone magnifier app when many users take breaks from work.

Methods
The number of launches of the SuperVision Magnifier app was determined retrospectively from 2018 to 2020 from among active users worldwide. The fluctuation in app usage was examined by comparing weekday vs weekend periods, Christmas and new year vs nonholiday seasons, and COVID-19 lockdowns vs the easing of restriction during the pandemic.

Results
On average, the app was used 262,466 times by 38,237 users each month in 2020 worldwide. There were two major trough points on the timeline of weekly app usage, one aligned with the COVID-19 lockdowns in April 2020 and another aligned with the Christmas and new year week in 2018 and 2019. The app launches declined by 6947 (11% decline; P<.001) during the lockdown and by 5212 (9% decline; P=.001) during the holiday weeks. There was no significant decline during March to May 2019. App usage compensated for seasonal changes was 8.6% less during weekends than during weekdays (P<.001).

Conclusions
The need for vision assistance technology was slightly lower during breaks and lockdowns, probably because the activities at home were different and less visually demanding. Nevertheless, for the entire user population, the needs for visual aids are still substantial.
Tetrahydrocannabinol and Skin Cancer: Analysis of YouTube Videos
Authors: Mamo Andrina , Szeto Mindy D , Mirhossaini Roya , Fortugno Andrew , Dellavalle Robert P 
Published: May 2021

Background
Cannabis oil is being used topically by patients with skin cancer as a homeopathic remedy, and has been promoted and popularized on social media, including YouTube. Although topical cannabinoids, especially tetrahydrocannabinol (THC), may have antitumor effects, results from a sparse number of clinical trials and peer-reviewed studies detailing safety and efficacy are still under investigation.

Objective
We sought to assess the accuracy, quality, and reliability of THC oil and skin cancer information available on YouTube.

Methods
The 10 most-viewed videos on THC oil and skin cancer were analyzed with the Global Quality Scale (GQS), DISCERN score, and useful/misleading criteria based on presentation of erroneous and scientifically unproven information. The videos were also inspected for source, length, and audience likes/dislikes. Top comments were additionally examined based on whether they were favorable, unfavorable, or neutral regarding the video content.

Results
All analyzed videos (10/10, 100%) received a GQS score of 1, corresponding to poor quality of content, and 9/10 (90%) videos received a DISCERN score of 0, indicating poor reliability of information presented. All 10 videos were also found to be misleading and not useful according to established criteria. Top comments were largely either favorable (13/27, 48%) or neutral (13/27, 48%) toward the content of the videos, compared to unfavorable (1/27, 4%).

Conclusions
Dermatologists should be aware that the spread of inaccurate information on skin cancer treatment currently exists on popular social media platforms and may lead to detrimental consequences for patients interested in pursuing alternative or homeopathic approaches.
PHARMACODYNAMIC INTERACTION OF TINOSPORA CORDIFOLIA WITH ATENOLOL AND PROPRANOLOL IN ISOPROTERENOL INDUCED CARDIAC NECROSIS IN RATS
Authors: SAVANT CHETAN , KULKARNI VENKATRAO H. , HABBU PRASANNA V. , MAJEED MUHAMMED , NAYAK MAHADEVA 
Published: May 2021

Objective: The present study was carried out to evaluate the combined cardioprotective effect of standardized extract of Tinospora cordifolia extract (TCE) with atenolol (AT) and propranolol (PP) in isoproterenol (ISO) induced cardiac necrosis in rats.
Methods: Myocardial infarction (MI) or cardiac necrosis was induced by subcutaneous administration of ISO for two days consecutively at an interval of 24 h. Rats were pre-administered with test drugs for 21 d followed by ISO was administration on 20 and 21st day. 24 h after final ISO administration, mean arterial blood pressure (MAB), Heart rate (HR), electrocardiogram (ECG), heart bio-marker enzyme, and histopathological study of cardiac tissue were evaluated from control and experimental groups and analyzed statistically by one-way ANOVA followed by Tukeys’s test.
Results: Rats administered with ISO showed significant (p<0.001) changes in ECG, HR, MAB, heart bio-marker enzyme, antioxidant parameters, and histopathology of the heart. The activities of biomarkers have reduced in serum and there is a significant (p<0.001) increase in antioxidants in the heart tissue of animals treated with drug combination. Similarly, ECG, MAB, and HR were restored to normalcy in drug-treated animals.
Conclusion: It may be concluded that the herb-drug combinations i. e TCE (500 mg/kg)+AT (10 mg/kg) and TCE (500 mg/kg)+PP (10 mg/kg) has shown increased cardioprotective activity than they were used alone.
EVALUATION OF INVOLVEMENT OF NEURO-CHEMICAL MECHANISM IN VALERIANA WALLICHII INDUCED ANTIDEPRESSANT EFFECT IN MICE
Authors: MEENA HARSAHAY , JOSHI V. K. , BALA MADHU 
Published: May 2021

Objective: Valeriana (V) wallichii DC is found among the ground flora of Himalayan regions and used as herbal medicine for CNS disorders in Indian systems of medicine. In the study, aimed to investigation of involvement of neuro-chemical-systems in V. wallichii induced antidepressant effects in mice.
Methods: The antidepressant activity of aqueous alcoholic extracts of V. wallichii was measured by using Forced Swim Test and Tail Suspension Test in mice, whereas locomotor activity was observed by Actophotometer. Involvement of adrenergic, dopaminergic and serotonergic receptors in V. wallichii induced antidepressant effects in mice were also observed.
Results: Sub-acute administration of V. wallichii in mice showed significant (P<0.05) increase in the antidepressant activity similar to the Imipramine, but did not show at lower doses in FST. Whereas, pretreatment of adrenergic receptor antagonist, dopaminergic receptor antagonist and serotonin synthesis inhibitor prevented V. wallichii induce anti-depressant effect in mice. Lower doses of hydoalcoholic extract of V. wallichii did not interfering the locomotor activity in mice during the sub-acute administration, but at a higher dose significantly (P<0.05) decreases the locomotor activity.
Conclusion: Hence, it is concluded that the antidepressant effect of V. wallichii in mice may mediate via adrenergic, dopaminergic and serotonergic systems.
Assetization: A technoscientific or financial phenomenon?
Authors: Golka Philipp 
Published: May 2021

AbstractFinance and financialization have dominated scholarship on capitalism and society for the past decade. Although scholars noted early on that the expansion of finance relies on the creation (and trade) of new financial assets, assets and assetization have been a blind spot as scholarship continued to focus on financial markets (Langley, 2020). This, however, is currently about to change as a number of landmark publications have been published in the past months that point toward growing momentum in the field of asset and assetization research. In this short essay, I review Kean Birch and Fabian Muniesa's edited collection, Assetization: Turning Things into Assets in Technoscientific Capitalism, which is of central importance to said momentum, and put it into dialogue with some of the other recent publications on this topic.
The Santiago de Cuba earthquake of 11 June 1766: Some new insights
Authors: Cotilla Rodríguez M. O. 
Published: May 2021

La información del terremoto reportado en Santiago de Cuba el día 11 de junio de 1766 ha sido re-evaluada en detalle. Para ello se han empleado datos del Archivo de Indias, Sevilla, y de otras fuentes bibliográficas. Este terremoto fue perceptible en un área muy extensa que incluyó a La Habana y a Jamaica. Fue posible cartografiar la distribución de los daños producidos en las diferentes poblaciones. El número total de fallecidos se situó entre 34 y 40 personas y en 700 los heridos. No se produjo tsunami. La localización aproximada del epicentro es 19.9°N, -76.1°W, dentro de la zona de fallas de Bartlett - Caimán. La profundidad focal se fijó a 25 km, mientras que la intensidad sísmica estimada fue IX (MSK) y la magnitud (Ms) alcanzó el valor de 6.8. Entre los años 1578 y 1842 en este sector marino se reportaron otros terremotos fuertes: cuatro de I=8 (MSK) y seis de I=7 (MSK). 170 ï¿½eep>	ï¿½6	agua. Anomalous (high) b-values in the lower part of the slab were located at depths of 50-90 km and 50-160 km beneath Guatemala-El Salvador and Nicaragua, respectively. Anomalies observed at the upper part of the slab may be related to dehydration and successive increase in pore pressure in the down-going lithosphere, which may generate volcanism above the anomalies in the upper part of the slab. Anomalies on the lower surface of the Wadati-Benioff zone are likely to be associated with high thermal gradients between the slab and mantle. te ï¿½Nrop>	ï¿½6	itosfera. Las anomalías en la parte inferior de la zona de Wadati-Benioff podrían estar asociadas con el alto gradiente térmico entre la litosfera y el manto.
Validitas Isi Pada Alat Evaluasi Buku Teks Pelajaran Bahasa Indonesia Kelas X SMA
Authors: Kaaffah Rifada Robitha Silmi , Wijiyono Andi Wibowo , Rahmayanti Indah 
Published: May 2021

Penelitian ini bertujuan untuk melihat validitas isi, indikator pencapain,dan aspek kognitif pada tes formatif buku teks Cerdas Berbahasa Kelas X SMA. Metode yang digunakan dalam penelitian yaitu metode analisis deskriptif kualitatif Teknik pengumpulan data yang digunakan yaitu metode dokumentasi. Dalam metode dokumentasi, peneliti memegang check list untuk mencari variabel yang sudah ditentukan. Hasil yang ditemukan ditinjau dari kesesuaiannya dengan kompetensi dasar dan indikator capaian pada kurikulum 2013 revisi, maka alat evaluasi di buku terbitan nondinas ini sudah sesuai, artinya valid jika dinilai berdasarkan validitas isinya. Hal ini dibuktikan dengan tingginya hasil persentasi. Hasil persentasi menunjukan 100% sesuai. Butir soal sesuai kompetensi dasar yang ada pada kurikulum 2013 revisi. Selain itu, butir soal juga sesuai dengan materi yang disajikan di dalam buku teks, sehingga mampu mengukur tingkat penguasaan materi peserta didik. Berdasarkan diagram di atas menunjukan bahwa persentasi aspek pengetahuan sebesar 32%, aspek pemahaman sebesar 30%, aspek aplikasi sebesar 4%, aspek analisis sebesar 32%, dan aspek sintesis sebesar 2%. Alat evaluasi bentuk pilihan ganda pada teks ini dikatakan cukup sesuai dengan HOTS yang diinginkan dalam kurikulum 2013 revisi karena tingginya persentasi tiga aspek tingkat berpikir dasar (pengetahuan, pemahaman, dan aplikasi), yakni sebesar 66%. Soal HOTS adalah soal yang mampu mendorong peserta didik berpikir tingkat tinggi, seperti menganalis, mensitesis, dan mengevaluasi. Kesimpulan penelitian ini bahwa alat evaluasi pada buku teks Bahasa Indonesia Kelas X SMA valid ditinjau dari validitas isi (Kompetensi dasar, indikator capaian, dan aspek kognitif). Hal ini ditujukan dengan perolehan skor, aspek kesesuaian kompetensi dasar dan indikator capaian 100% (sangat sesuai). Jika ditinjau berdasarkan aspek kognitif maka butir soal hanya mampu mengukur kognitif tingkat dasar saja, karena tingginya persentasi sebesar 66%. Dengan demikian alat evaluasi pada buku teks bahasa Indonesia Kelas X SMA dinilai valid ditinjau dari validitas isi, sehingga dapat digunakan sebagai sumber utama pembelajaran di kelas. Penelitian ini bermanfaat untuk akademisi dan guru untuk mempertimbangkan buku teks bahasa Indonesia yang akan digunakan dalam pembelajaran di kelas.
Kata kunci: Validitas Isi; Alat Evaluasi; Buku Teks
Assessing the Relevance of County-Level Eco-Efficiency to Single-Family Housing Prices
Authors: Akaaboune Ouadie , Quarles Ross , Burnett Royce D. 
Published: May 2021

ABSTRACT
Eco-efficiency has been used in the private sector to measure how resources are used to produce environmental outcomes. In these instances, eco-efficiency has a reported signaling effect that increases value for stakeholders. Public sector research suggests increased spending on social goods at the national (country) level results in reduced emissions with the resulting effect of an improved environment. This study extends previous research by applying eco-efficiency to the public sector in a significantly different public entity, county government, and by linking spending on social goods (input) and emissions (output) to a direct outcome of measurable economic value to citizenry, single-family housing prices, for 66 Florida counties during the years 2005–2014. Results show a positive and significant relationship between eco-efficiency and single-family housing prices. These results suggest county-level eco-efficiency may be an important element to include in external reports to citizens.
Renal Replacement Therapy in People With and Without Diabetes in Germany, 2010–2016: An Analysis of More Than 25 Million Inhabitants
Authors: Claessen Heiner , Narres Maria , Kvitkina Tatjana , Wilk Adrian , Friedel Heiko , Günster Christian , Hoffmann Falk , Koch Michael , Jandeleit-Dahm Karin , Icks Andrea 
Published: May 2021

OBJECTIVE
Epidemiological studies have shown contradictory results regarding the time trend of end-stage renal disease (ESRD) in people with diabetes. This study aims to analyze the incidence of ESRD, defined as chronic renal replacement therapy (RRT), to investigate time trends among people with and without diabetes in Germany and to examine whether these patterns differ by age and sex.

RESEARCH DESIGN AND METHODS
The data were sourced from nationwide data pooled from two German branches of statutory health insurances covering ∼25 million inhabitants. We estimated age- and sex-standardized incidence rates (IRs) for chronic RRT among people with and without diabetes in 2010–2016 and the corresponding relative risks. Time trends were analyzed using Poisson regression.

RESULTS
We identified 73,638 people with a first chronic RRT (male 60.0%, diabetes 60.6%, mean age 71.3 years). The IR of chronic RRT among people with diabetes (114.1 per 100,000 person-years [95% CI 110.0–117.2]) was almost six times higher than among people without diabetes (19.6 [19.4–19.8]). A consistent decline in IR was observed among people with diabetes (3% annual reduction, P &lt; 0.0001) for both sexes and all age classes. In contrast, no consistent change of IR was identified in people without diabetes. Only among women aged &lt;40 years (P = 0.0003) and people aged ≥80 years (P &lt; 0.0001) did this IR decrease significantly.

CONCLUSIONS
Incidence of chronic RRT remained significantly higher among people with diabetes. The IR decreased significantly in people with diabetes independent of age and sex. Time trends were inconsistent in people without diabetes.
NÉCTAR DE CARAMBOLO (Averrhoa carambola) Y LIMONARIA (Cymbopogon citratus) COMO ALTERNATIVA DE TRASFORMACIÓN DE RECURSOS AGRÍCOLAS EN LA REGIÓN
Authors: Castro Escorcia Yaceris , Altamar Pérez Teresa De Jesús 
Published: May 2021

Las plantas aromáticas como la limonaria son utilizadas mayoritariamente en la preparación de infusiones a nivel casero. El consumo y el uso tradicional de aromáticas se realizan principalmente en estado fresco y con fines terapéuticos respectivamente, así mismo el uso del fruto de Carambolo tradicionalmente es en fresco o en decoraciones de eventos. Colombia cuenta con una diversidad de recursos vegetales incluyendo frutas y plantas aromáticas que son una fuente potencial para la innovación en el desarrollo de productos alimenticios, además son una fuente potencial de una gran variedad de micronutrientes y compuestos bioactivos como los compuestos fenólicos antioxidantes. El propósito de este proyecto fue la obtención de un néctar de carambolo y limonaria como estrategia del aprovechamiento de recursos vegetales disponibles en la región como Carambolo y Limonaria. Para el desarrollo de esta bebida se realizó un diseño experimental, el utilizado fue el factorial 33, con nueve (9) tratamientos tomados de forma aleatoria, donde se establecieron factores como: Sólidos solubles, Temperatura de pasteurización y pH, paraobtener como variable de respuesta el grado de aceptabilidad del producto en cumplimiento de parámetros técnicos y sensoriales. La metodología aplicada consistió en realizar una formulación utilizando la pulpa extraída de carambolos seleccionados de con un grado madurez entre 8 y 11ºBrix. La limonaria previamente deshidratada la cual fue sometida a una infusión de 90°C por 5 minutos, posteriormente se mezcló con el agua según la formulación, la pulpa y el resto de los ingredientes ácido ascórbico y azúcar; inmediatamente se pasteurizo a 80°C por 5 min. Luego se empaca herméticamente y se almacena. Una vez obtenido el producto se realiza la estandarización del néctar donde se establecen los mecanismos de control del proceso productivo de acuerdo con lo establecido en la norma NTC 5468 Zumos (jugos), néctares, purés (pulpas) y concentrados de frutas. Los resultados obtenidos determinaron que el tratamiento con mejor comportamiento fue el No. 5, el cual mostro un porcentaje de aceptación de 87%. Sus parámetros de calidad fueron de sólidos solubles 13°Brix, 4,2 pH, acidez 0.35% conservando sus propiedades de calidad. En lo relacionado con el análisis bromatológico la proteína 0,25%, grasa 0%, fibra 0%, humedad 85%. Los análisis microbiológicos se evaluaron Mesófilos, Mohos y levaduras, Coliformes, bacterias acido lácticas, esporas Clostridium sulfito reductoras de acuerdo con lo establecido en la norma y los resultados obtenidos indicaron que el producto no representa riesgo para el consumidor. Los análisis sensoriales demostraron el grado de aceptación del producto en un 81% de acuerdo a lo expresado por los 30 panelista con edades entre 18 – 30 años.
Use of a hybrid external skeletal fixator construct for managing tibial tuberosity avulsion fractures in three dogs
Authors: Verpaalen Valentine D. , Lewis Daniel D. 
Published: May 2021

Abstract

CASE DESCRIPTION
3 juvenile (4 to 5 months of age) medium- to large-breed or crossbred dogs were evaluated for sudden unilateral non–weight-bearing lameness in a pelvic limb after a fall during strenuous activity.

CLINICAL FINDINGS
All dogs had non–weight-bearing lameness (n = 2) or bore minimal weight (1) on the affected pelvic limb, had soft tissue swelling over the cranial aspect of the stifle joint in the affected limb, seemed to resist manipulation of the affected joint, and had tibial tuberosity avulsion fracture confirmed with radiography.

TREATMENT AND OUTCOME
Each dog underwent surgical fracture reduction and stabilization with a hybrid circular-linear external skeletal fixator construct with interfragmentary Kirschner wires used to stabilize the avulsed tibial tuberosity. Successful fracture reduction and stabilization were achieved, and only minor postoperative complications occurred. Construct removal 2 weeks postoperatively resulted in no displacement of the tibial tuberosity in 2 dogs and only minor proximal displacement in the remaining dog, allowed for continued unencumbered growth through the apophysis and proximal tibial epiphysis in all dogs, and did not result in tibial conformational anomalies. Clinical outcome was considered excellent in 2 dogs with complete resolution of lameness and good in 1 dog with subsequent occasional mild lameness.

CLINICAL RELEVANCE
Our findings suggested that the described hybrid external skeletal fixator construct could be used as a minimally invasive strategy to successfully manage tibial tuberosity avulsion fractures in dogs and may be advantageous in very young medium- to large-breed dogs in which premature closure of the tibial tuberosity apophysis could result in distal translocation of the tibial tuberosity and deformity of the tibial plateau.
Cryptorchidectomy with a paramedian or inguinal approach in domestic pigs: 47 cases (2000–2018)
Authors: Skelton Jase A. , Baird Aubrey N. , Hawkins Jan F. , Ruple Audrey 
Published: May 2021

Abstract

OBJECTIVE
To describe cryptorchidectomy performed with a paramedian or inguinal approach in domestic pigs and compare findings for commercial-breed pigs with those for pot-bellied pigs.

ANIMALS
47 client-owned (33 commercial-breed and 14 pot-bellied) pigs.

PROCEDURES
Medical records were searched to identify pigs that underwent surgical treatment for cryptorchidism from 2000 to 2018. Signalment, location of retained testes, surgeon, surgical approach, surgery time, anesthesia time, and postoperative complications were recorded. Complications were assessed with long-term follow-up. Age and surgical variables were compared between commercial-breed pigs and pot-bellied pigs.

RESULTS
Retained testes were most commonly located in the abdomen (27/47 [57%] left-sided, 15/47 [32%] right-sided, and 2/47 [4%] bilateral); 2 pigs each had 1 retained testis in the inguinal region, and 1 pig had 1 retained testis in the abdomen and 1 in the inguinal region. Forty-four pigs with abdominally retained testes were treated successfully with a paramedian surgical approach, including 3 for which an inguinal approach was attempted first. An inguinal approach was successful for 3 pigs with inguinally retained testes and 1 with an abdominally retained testis. Standard castration techniques were used for normally descended and inguinally retained testes. Long-term follow-up was available for 34 pigs; minor complications were reported for 3 (9%). Pot-bellied pigs were significantly older than commercial-breed pigs. No other intergroup differences were found.

CONCLUSIONS AND CLINICAL RELEVANCE
The paramedian surgical approach was successfully used for removal of abdominally retained testes in all pigs that underwent the procedure. The overall complication rate for cryptorchidectomy in the study sample was low.
On the generalized fractional Laplace transform
Authors: Kumar Virendra 
Published: May 2021

Abstract
In the present paper a generalization of the Laplace transform is introduced and studied. Its inversion formula is also obtained. As an application, we obtain the generalized fractional Laplace transform of a general class of functions and a product of the Fox’s H- function and general class of functions. The results obtained are of general nature and capable of yielding a large number of known or new results as special cases. For illustration, some special cases involving important special functions are mentioned.
Jacobson’s Lemma in the ring of quaternionic linear operators
Authors: Benabdi El Hassan , Barraa Mohamed 
Published: May 2021

Abstract
In the present paper, we study the Jacobson’s Lemma in the unital ring of all bounded right linear operators ℬ
R
(X) acting on a two-sided quaternionic Banach space X. In particular, let A, B ∈ ℬ
R
(X) and let q ∈ ℍ \ {0}, we prove that w(AB) \ {0} = w(BA) \ {0} where w belongs to the spherical spectrum, the spherical approximate point spectrum, the right spherical spectrum, the left spherical spectrum, the spherical point spectrum, the spherical residual spectrum and the spherical continuous spectrum. We also prove that the range of (AB)2 − 2Re(q)AB + |q|2
I is closed if and only if (BA)2 − 2Re(q)BA + |q|2
I has closed range. Finally, we show that (AB)2 − 2Re(q)AB + |q|2
I is Drazin invertible if and only if (BA)2 − 2Re(q)BA + |q|2
I is.