bluuebunny/crossref_metadata_2025_split huggingface dataset:
Civility as Public-Mindedness During COVID-19
Authors: Bonotti Matteo , Zech Steven T. 
Published: March 2021

AbstractThis chapter examines the implications of COVID-19 for civility as public-mindedness. First, the pandemic has exacerbated various types of morally uncivil behaviour, such as discrimination and hate. Moreover, COVID-19 has created opportunities for some political actors to put forward sectarian agendas, grounded in partial interests and controversial beliefs, that breach the demands of justificatory civility. Furthermore, some policies to contain the pandemic have resulted in unreasonable ‘strains of commitment’ for members of marginalized sectors of the population, such as racial minorities, women, the LGBTIQ+ community, and older people; governments should acknowledge this aspect when publicly justifying these policies. Finally, justificatory civility during the pandemic has been undermined by scientific uncertainty around particular aspects of the virus itself; limited research on its social and cultural dimensions; and the politicization of science for personal or partisan advantage. The chapter advances numerous suggestions to counteract these challenges to moral and justificatory civility.
Dynamic consistency, valuable information and subjective beliefs
Authors: Galanis Spyros 
Published: March 2021

AbstractAmbiguity sensitive preferences must fail either Consequentialism or Dynamic Consistency (DC), two properties that are compatible with subjective expected utility and Bayesian updating, while forming the basis of backward induction and dynamic programming. We examine the connection between these properties in a general environment of convex preferences over monetary acts and find that, far from being incompatible, they are connected in an economically meaningful way. In single-agent decision problems, positive value of information characterises one direction of DC. We propose a weakening of DC and show that one direction is equivalent to weakly valuable information, whereas the other characterises the Bayesian updating of the subjective beliefs which are revealed by trading behavior.
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
Authors: Schirmer Cedric , Maschke Rüdiger W. , Pörtner Ralf , Eibl Dieter 
Published: March 2021

AbstractNo matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts.Key Points• Basic design of the most frequently used bioreactor type: the stirred tank bioreactor• Differences in most common seal types in stirred systems and fields of application• Comprehensive overview of commercially available bioreactor seal types• Increased use of magnetically driven agitation systems in single-use bioreactors
Stochastic Wave–Current Interaction in Thermal Shallow Water Dynamics
Authors: Holm Darryl D. , Luesink Erwin 
Published: March 2021

AbstractHolm (Proc R Soc A Math Phys Eng Sci 471(2176):20140963, 2015) introduced a variational framework for stochastically parametrising unresolved scales of hydrodynamic motion. This variational framework preserves fundamental features of fluid dynamics, such as Kelvin’s circulation theorem, while also allowing for dispersive nonlinear wave propagation, both within a stratified fluid and at its free surface. The present paper combines asymptotic expansions and vertical averaging with the stochastic variational framework to formulate a new approach for developing stochastic parametrisation schemes for nonlinear waves in fluid dynamics. The approach is applied to two sequences of shallow water models which descend from Euler’s three-dimensional fluid equations with rotation and stratification under approximation by asymptotic expansions and vertical averaging. In the entire family of nonlinear stochastic wave–current interaction equations derived here using this approach, Kelvin’s circulation theorem reveals a barotropic mechanism for wave generation of horizontal circulation or convection (cyclogenesis) which is activated whenever the gradients of wave elevation and/or topography are not aligned with the gradient of the vertically averaged buoyancy.
Modelling and measurements of distributions in an adult human phantom undergoing proton scanning beam radiotherapy: lung- and prostate-located tumours
Authors: Puchalska Monika 
Published: March 2021

AbstractProton radiotherapy has been shown to offer a significant dosimetric advantage in cancer patients, in comparison to conventional radiotherapy, with a decrease in dose to healthy tissue and organs at risk, because the bulk of the beam energy is deposited in the Bragg peak to be located within a tumour. However, it should be kept in mind that radiotherapy of cancer is still accompanied by adverse side effects, and a better understanding and improvement of radiotherapy can extend the life expectancy of patients following the treatment of malignant tumours. In this study, the dose distributions measured with thermoluminescent detectors (TLDs) inside a tissue-equivalent adult human phantom exposed for lung and prostate cancer using the modern proton beam scanning radiotherapy technique were compared. Since the TLD detection efficiency depends on the ionization density of the radiation to be detected, and since this efficiency is detector specific, four different types of TLDs were used to compare their response in the mixed radiation fields. Additionally, the dose distributions from two different cancer treatment modalities were compared using the selected detectors. The measured dose values were benchmarked against Monte Carlo simulations and available literature data. The results indicate an increase in the lateral dose with an increase of the primary proton energy. However, the radiation quality factor of the mixed radiation increases by 20% in the vicinity to the target for the lower initial proton energy, due to the production of secondary charged particles of low-energy and short range. For the cases presented here the MTS-N TLD detector seems to be the most optimal tool for dose measurements within the target volume, while the MCP-N TLD detector, due to an interplay of its enhanced thermal neutron response and decreased detection efficiency to highly ionising radiation, is a better choice for the out-of-field measurements. The pairs of MTS-6 and MTS-7 TLDs used also in this study allowed for a direct measurement of the neutron dose equivalent. Before it can be concluded that they offer an alternative to the time-consuming nuclear track detectors, however, more research is needed to unambiguously confirm whether this observation was just accidental or whether it only applies to certain cases. Since there is no universal detector, which would allow the determination of the dosimetric quantities relevant for risk estimation, this work expands the knowledge necessary to improve the quality of dosimetry data and might help scientists and clinicians in choosing the right tools to measure radiation doses in mixed radiation fields.
Cerebrospinal fluid analysis in Guillain–Barré syndrome: value of albumin quotients
Authors: Rath Jakob , Zulehner Gudrun , Schober Bernadette , Grisold Anna , Krenn Martin , Cetin Hakan , Zimprich Fritz 
Published: March 2021

Abstract
Background
Albuminocytologic dissociation in cerebrospinal fluid (CSF) is a diagnostic hallmark of Guillain–Barré syndrome (GBS). Compared to CSF total protein (TP), the CSF/serum albumin quotient (Qalb) has the advantage of method-independent reference ranges. Whether the diagnostic yield differs between Qalb and CSF-TP is currently unknown.

Methods
We retrospectively analyzed the diagnostic yield (i.e., a value above the URL indicating blood–nerve barrier dysfunction) of Qalb and CSF-TP levels in patients with GBS. We evaluated two different equations (Reiber’s and Hegen’s) for age-adjusted URLs of Qalb and compared results to CSF-TP using the standard URL of 0.45 g/L as well as age-adjusted URLs (by decade of age). Additionally, multivariable logistic regression analysis was used to assess the effect of clinical factors on the diagnostic yield.

Results
We analyzed 110 patients [62% males; median age 48 (IQR 35–58)] with sensorimotor (68), motor (16), sensory (12) and localized (8) GBS as well as Miller Fisher syndrome (6).
Qalb and CSF-TP were highly correlated (r = 0.95, p < 0.001). The diagnostic yield of Qalb was 65% with Reiber’s and 47% with Hegen’s age-adjusted URLs compared to 66% with the fixed CSF-TP URL of 0.45 g/L and 49% with age-adjusted CSF-TP URLs. A longer duration from clinical onset to lumbar puncture was associated with a higher diagnostic yield.

Conclusion
Qalb strongly correlates with CSF-TP in patients with GBS with a similar diagnostic yield for the detection of a blood–nerve barrier dysfunction. However, the diagnostic yield of both values is lower when using more recent age-adjusted URLs and at earlier timepoints.
Further evidence against the role renal medullary perfusion in short-term control of arterial pressure in normotensive and mildly or overtly hypertensive rats
Authors: Bądzyńska Bożena , Baranowska Iwona , Sadowski Janusz 
Published: March 2021

AbstractEarlier evidence from studies of rat hypertension models undermines the widespread view that the rate of renal medullary blood flow (MBF) is critical in control of arterial pressure (MAP). Here, we examined the role of MBF in rats that were normotensive, with modest short-lasting pressure elevation, or with overt established hypertension. The groups studied were anaesthetised Sprague-Dawley rats: (1) normotensive, (2) with acute i.v. norepinephrine-induced MAP elevation, and (3) with hypertension induced by unilateral nephrectomy followed by administration of deoxycorticosterone-acetate (DOCA) and 1% NaCl drinking fluid for 3 weeks. MBF was measured (laser-Doppler probe) and selectively increased using 4-h renal medullary infusion of bradykinin. MAP, renal excretion parameters and post-experiment medullary tissue osmolality and sodium concentration were determined. In the three experimental groups, baseline MAP was 117, 151 and 171 mmHg, respectively. Intramedullary bradykinin increased MBF by 45%, 65% and 70%, respectively, but this was not associated with a change in MAP. In normotensive rats a significant decrease in medullary tissue sodium was seen. The intramedullary bradykinin specifically increased renal excretion of water, sodium and total solutes in norepinephrine-treated rats but not in the two other groups. As previously shown in models of rat hypertension, in the normotensive rats and those with acute mild pressure elevation (resembling labile borderline human hypertension), 4-h renal medullary hyperperfusion failed to decrease MAP. Nor did it decrease in DOCA-salt model mimicking low-renin human hypertension. Evidently, within the 4-h observation, medullary perfusion was not a critical determinant of MAP in normotensive and hypertensive rats.
Video surveillance methods to evaluate individual feeding response in rainbow trout (Oncorhynchus mykiss, Walbaum)—implications for feeding regime optimisation
Authors: Just Philip Niclas , Köllner Bernd , Slater Matthew James 
Published: March 2021

AbstractPrecisely analysing and optimising feeding regimes is central to salmonid growth performance and delivery of special diets. The current study developed novel video surveillance methods and analysis techniques to assess individual feed intake and minimum pellet intake (MPI) in individually identified juvenile rainbow trout, Oncorhynchus mykiss. Three trials were conducted to test the impact of short-term starvation (N=112 [16 tanks, 7 fish per tank], average weight=27.1±3.4g, age= 119 days), portion numbers per feeding (N=105 [15 tanks, 7 fish per tank], average weight=22.8±2.1g, age= 99 days) and varied numbers of daily feeding events (N=84 [12 tanks, 7 fish per tank], average weight=32.4±3.3g, age= 133 days). All trails were carried out in a recirculating aquaculture system with 20 tanks held at 15 ± 0.5°C. All individuals were code-tagged and high quality video images were taken and analysed to identify all feeding interactions. Individual trout feeding activity under different feeding regimes could be precisely analysed with the video methods developed. Moving from one to two daily feeding events doubled pellet intake per fish from 27.4 ± 5.8 to 52.8 ± 11.5 pellets. Pellet intake (58.8 ± 24.2 pellets) did not increase at three daily feeding events but became more variable across fish. MPI nearly doubled to 30 pellets in fish receiving two daily feeding events (MPI30: chi-squared = 8.74, df = 2, p = 0.01). Short-term starvation had no influence on intake (28 ± 8 pellets/fish) or MPI. Increasing portion number from one (27.8 ± 7.4 pellets fish−1) to two (31.1 ± 7.4 pellets fish−1) or more did not significantly increase the number of ingested pellets. Adjusting the feeding regime by increasing daily feeding events to two, possibly combined with multiple portions, can increase pellet intake and reduce the heteroscedasticity of pellet intake. The methods presented in this study are viable for analysing feeding regimes for juvenile rainbow trout and controlled feedstock/supplement delivery. Implications for analyses with other species and for vaccination optimisation are discussed.
Moisture induced straining of the cellulosic microfibril
Authors: Salmén Lennart , Stevanic Jasna S. , Holmqvist Claes , Yu Shun 
Published: March 2021

Abstract
Moisture absorption in the cell wall structure of wood is well known to induce considerable swelling of the wood exerting high expansion forces. This swelling is mainly induced by the sorptive action of the hydroxyl groups of the carbohydrate wood polymers; cellulose and hemicelluloses. On the ultrastructural level, there are, however, still questions with regard to the detailed deformations induced by this moisture absorption. Here, FTIR spectroscopy and synchrotron-radiation-based X-ray diffraction were used on paper samples to study the deformation of the cellulose crystals as a consequence of moisture absorption and desorption. Both techniques revealed that the moisture absorption resulted in a transverse contraction of the cellulose crystals accompanied by a somewhat smaller elongation in the cellulose chain direction. The deformations were found to be a direct response to the increased moisture content and were also found to be reversible during moisture desorption. It is hypothesised that these deformations are a consequence of the swelling forces created by the combined longitudinal and lateral expansions of the non-crystalline cellulose molecules and the glucomannan hemicellulose aligned along the cellulose crystals. These forces will impose a lateral contraction of the cellulose crystals, as well as a longitudinal extension of it.

Graphic abstract
Pre-treatments of pre-consumer cotton-based textile waste for production of textile fibres in the cold NaOH(aq) and cellulose carbamate processes
Authors: Määttänen Marjo , Gunnarsson Maria , Wedin Helena , Stibing Sara , Olsson Carina , Köhnke Tobias , Asikainen Sari , Vehviläinen Marianna , Harlin Ali 
Published: March 2021

AbstractRecycling of textiles is of importance due to the large amount of waste generated from the increasing consumption and use worldwide. Cotton-rich pre-consumer textiles are considered as potential raw material for production of man-made regenerated fibres, but demands purification from the blends with synthetic fibres as well as the dyes and finishing chemicals. In this study we explore the use of different pre-treatments of pre-consumer textiles to meet specific parameters for production of fibres in the cold NaOH(aq) or cellulose carbamate process. The pre-treatments consisted of different bleaching sequences and were performed on both uncoloured and coloured pre-consumer textiles. For the uncoloured textile, degree of polymerisation and amount of inorganic content was efficiently reduced making the material suitable for both the cold NaOH(aq) and the cellulose carbamate process. In case of the coloured textile, the pre-treatments were able to remove the dye and decrease the inorganic content as well as reduce the degree of polymerisation but only sufficiently enough for production of fibres in the cellulose carbamate process. The work was able to prove a fibre-to-fibre concept while further optimisation of the regeneration steps is expected to improve the mechanical properties of the produced fibres in future studies.
Measurements meet human observations: integrating distinctive ways of knowing in the Pamir Mountains of Tajikistan to assess local climate change
Authors: Haag Isabell , Kassam Karim-Aly , Senftl Thomas , Zandler Harald , Samimi Cyrus 
Published: March 2021

AbstractIn mountain environments dimensions of climate change are unclear because of limited availability of meteorological stations. However, there is a necessity to assess the scope of local climate change, as the livelihood and food systems of subsistence-based communities are already getting impacted. To provide more clarity about local climate trends in the Pamir Mountains of Tajikistan, this study integrates measured climate data with community observations in the villages of Savnob and Roshorv. Taking a transdisciplinary approach, both knowledge systems were considered as equally pertinent and mutually informed the research process. Statistical trends of temperature and snow cover were retrieved using downscaled ERA5 temperature data and the snow cover product MOD10A1. Local knowledge was gathered through community workshops and structured interviews and analysed using a consensus index. Results showed, that local communities perceived increasing temperatures in autumn and winter and decreasing amounts of snow and rain. Instrumental data records indicated an increase in summer temperatures and a shortening of the snow season in Savnob. As both knowledge systems entail their own strengths and limitations, an integrative assessment can broaden the understanding of local climate trends by (i) reducing existing uncertainties, (ii) providing new information, and (iii) introducing unforeseen perspectives. The presented study represents a time-efficient and global applicable approach for assessing local dimensions of climate change in data-deficient regions.
Infant Survival Among Free-Living Bonnet Macaques (Macaca radiata) in South India
Authors: Arlet Małgorzata E. , Balasubramaniam Krishna N. , Saha Rajarshi , Beisner Brianne , Marty Pascal R. , Kaburu Stefano S. K. , Bliss-Moreau Eliza , Kaasik Ants , Kodandaramaiah Ullasa , McCowan Brenda 
Published: March 2021

AbstractFemale reproductive success depends to a large extent on infants’ ability to survive to maturity. While most studies of female reproductive success have focused on the effects of individuals’ sociodemographic factors (e.g., age/parity, dominance rank) on offspring survival among wild primates living in less disturbed habitats, little research has focused on offspring survival in urban or periurban animals. Here we investigated sociodemographic and anthropogenic determinants of infant survival (up to 1 yr of age) in free-ranging bonnet macaques (Macaca radiata) living in a periurban environment in Southern India. We conducted the study from November 2016 to May 2018, on two groups of bonnet macaques at the Thenmala tourist site in the state of Kerala. Fifty infants were born across two birth seasons. Of these infants, 29.2% died or disappeared in 2017 and 26.9% died or disappeared in 2018. We found that infant survival was strongly influenced by the mother’s parity: infants of experienced mothers had a better chance of survival than those of first-time mothers. We also found that male infants were more likely to die than female infants. However, we found no effects of mothers’ dominance rank, or of frequency of mothers’ interactions with humans and time spent foraging on anthropogenic food, on infant survival. Our results, consistent with findings from other wild primate species, show that even in challenging human-impacted environments, experienced bonnet macaque mothers have greater success than inexperienced ones.
Thymopoiesis, Alterations in Dendritic Cells and Tregs, and Reduced T Cell Activation in Successful Extracorporeal Photopheresis Treatment of GVHD
Authors: Flinn Aisling M. , Ehrlich Anna , Roberts Catherine , Wang Xiao Nong , Chou Janet , Gennery Andrew R. 
Published: March 2021

AbstractAcute graft-versus-host disease (aGVHD) is a significant complication of allogeneic hematopoietic stem cell transplant (HSCT) and negatively affects T cell reconstitution. Extracorporeal photopheresis (ECP) reduces aGVHD, but the mechanisms remain incompletely understood. Our objective was to examine the impact of ECP on thymopoiesis in pediatric aGVHD and the mechanisms at a cellular and transcriptional level. Sixteen pediatric HSCT patients were recruited: 6 with ECP-treated aGVHD, 5 without aGVHD, and 5 with aGVHD treated with corticosteroids only. Thymopoiesis was evaluated by measuring naive T cells, TRECs, IL-7, and T cell receptor repertoire diversity. Regulatory T cell (Treg) enumeration and function and dendritic cell (DC) enumeration and phenotype were analyzed using flow cytometry. T cell transcriptome analysis was performed on ECP patients after treatment and responders pre- and post-treatment. Four ECP responders demonstrated thymic-dependent T cell recovery, and superior median naïve T cell numbers at 8 and 12 months post-HSCT compared to the aGVHD corticosteroid group. Increased Tregs and Treg suppressive function, reduced cDC/pDC and DC co-stimulatory marker expression in ECP responders suggest upregulated peripheral tolerance; these findings were not observed in partial responders. Responder post-ECP CD3+ T cell transcriptional profile demonstrated 3333 downregulated and 364 upregulated genes, with significant downregulation of ERRα and GαS pathways, and reduced expression of pro-inflammatory and adhesion proteins.Thymic function improves with successful ECP treatment. ECP reduces T cell activation and impacts peripheral tolerance via DCs and Tregs. Differences in thymic recovery, DC, and Treg cellular patterns and the T cell transcriptome were observed between ECP responders and partial responders and require further validation and investigation in additional patients.