bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ and parents’ satisfaction with, and preference for, haemophilia A treatments: a cross‐sectional, multicentre, observational study
Authors: Park Young Shil , Hwang Tai Ju , Cho Goon Jae , Kim Soon Ki , Park Sang Kyu , Kim Ji Yoon , Baek Hee Jo , Kim Young‐Joo , Lee Ho‐Jin , Shin Ji‐Soo , Nam Chung‐Mo , Sun Jiyu , Yoo Ki Young 
Published: June 2021

ABSTRACTIntroductionReports on patients’ satisfaction and preferred characteristics for treatments would be worthwhile when choosing an optimal treatment reflecting patients’ perspectives.AimTo identify the characteristics and treatment patterns of patients with haemophilia A, or their caregivers, in Korea and explore patient preferences and satisfaction with their treatment.MethodsThis cross‐sectional, multicentre, observational study was conducted from April 2018 to September 2019 at six nationwide hospitals and three Korea Hemophilia Foundation clinics. Patients aged ≥16 years, or legal caregivers of paediatric patients, who had used factor VIII (FVIII) concentrates for ≥1 month were enrolled. Satisfaction with treatment was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM); preference was evaluated using discrete choice experiment (DCE), with 10 series of two hypothetical treatment options created from D‐efficient block design, which varied across five attributes.ResultsOverall, 505 patients (mean age 31 years) were enrolled in the study. Patients had received FVIII concentrate for an average of 102.9 months (prophylaxis: 53.5%; on‐demand: 22.2%). Mean TSQM scores were 64.6 (effectiveness domain), 97.9 (side effects), 57.1 (convenience) and 66.8 (global satisfaction). The number of vials per injection, and the frequency of drug administration, was significantly associated with treatment satisfaction. According to DCE, simpler treatment options were preferred by patients/caregivers.ConclusionThe lowest satisfaction levels were shown in the treatment convenience domain. Patients/parents preferred simpler and easier treatment characteristics. In an attempt to enhance the overall satisfaction of patients and caregivers with treatment, consideration of more convenient characteristics is required in future decisions regarding treatment selection.
Digital reminiscence app co‐created by people living with dementia and carers: Usability and eye gaze analysis
Authors: Boyd Kyle , Bond Raymond , Ryan Assumpta , Goode Deborah , Mulvenna Maurice 
Published: June 2021

AbstractBackgroundThis research reports on a pilot study that examined the usability of a reminiscence app called ‘InspireD’ using eye tracking technology. The InspireD app is a bespoke digital intervention aimed at supporting personalized reminiscence for people living with dementia and their carers. The app was developed and refined in two co‐creation workshops and subsequently tested in a third workshop using eye tracking technology.InterventionEye tracking was used to gain insight into the user's cognition since our previous work showed that the think‐aloud protocol can add to cognitive burden for people living with dementia while also making the test more unnatural.ResultsResults showed that there were no barriers to using a wearable eye tracker in this setting and participants were able to use the reminiscence app freely. However, some tasks required prompts from the observer when difficulties arose. While prompts are not normally used in usability testing (as some argue the prompting defeats the purpose of testing), we used ‘prompt frequency’ as a proxy for measuring the intuitiveness of the task. There was a correlation between task completion rates and prompt frequency. Results also showed that people living with dementia had fewer gaze fixations when compared to their carers. Carers had greater fixation and saccadic frequencies when compared to people living with dementia. This perhaps indicates that people living with dementia take more time to scan and consume information on an app. A number of identified usability issues are also discussed in the paper.Patient or Public ContributionThe study presents findings from three workshops which looked at user needs analysis, feedback and an eye tracking usability test combined involving 14 participants, 9 of whom were people living with dementia and the remaining 5 were carers.
Violence, Control and Restraint: The Harms to Young Adults Particularly Upon Transition
Authors: PRICE JAYNE 
Published: June 2021

AbstractThe transition into the young adult/adult estate at age 18 years is marked by a significant loss of provision and shift in institutional treatment. One of the many harms endured is the change in restraint which is harmful and damaging yet prevailing. The data presented here show how the distinct needs of this vulnerable population are widely overlooked. This article extends the literature regarding young adults and argues that there should be greater exploration and understanding of their behaviour and the impacts of transitions. This, in turn, leads to recommendations for changes to practices within the young adult/adult estate.
CONSISTENT EXPECTATIONS EQUILIBRIA IN MARKOV REGIME SWITCHING MODELS AND INFLATION DYNAMICS
Authors: Airaudo Marco , Hajdini Ina 
Published: June 2021

AbstractWe study the existence of Stochastic Consistent Expectations Equilibria (SCEE) in linear Markov regime switching models. An SCEE exists when the model‐implied mean and first‐order autocorrelation coincide with those predicted by the agents via misspecified forecasting rules. For a simple regime‐switching monetary policy model, the parametric space where at least one SCEE exists is rather wide, and may extend well beyond the rational expectations equilibrium determinacy frontier. Misspecified expectations combined with regime switching yield a strong endogenous amplification mechanism that help generate the near unit root dynamics for inflation observed in the United States before the Great Moderation.
Endogenous proteases in giant freshwater prawn (Macrobrachium rosenbergii): changes and its impacts on texture deterioration during frozen storage
Authors: Jiang Qixing , Gao Pei , Liu Jiatong , Yu Dawei , Xu Yanshun , Yang Fang , Wang Bin , Yu Peipei , Xia Wenshui 
Published: June 2021

SummaryEffects of endogenous enzymes on texture deterioration of Macrobrachium rosenbergii during frozen storage (−18 °C) were investigated. The prawn was pretreated with iodoacetic acid (IAA) solution to inhibit cysteine proteases and/or phenylmethylsulfonyl fluoride (PMSF) solution to inhibit trypsin before frozen storage, and sterile distilled water was used as the control. After 16 weeks of cryopreservation, the shear force of the groups treated with enzyme inhibitors was significantly higher than that of sterile distilled water‐treated group (control; P < 0.05), while significantly fewer TCA‐dissolved peptides, α‐amino nitrogen and Myofibril fragmentation index (MFI) value were observed in all inhibitor‐treated groups (P < 0.05). Compared with PMSF treatment, IAA or IAA + PMSF treatment effectively alleviated softening and remarkably reduced the accumulation of TCA‐soluble peptides and AAN (α‐amino nitrogen) during frozen storage, with a lower MFI value and a higher sodium dodecyl sulphate‐polyacrylamide gel electrophoresis band intensity. Therefore, endogenous cysteine proteases in muscle play a crucial part in texture deterioration of giant freshwater prawn during cryopreservation.
Extruded chickpea flour sequentially treated with alcalase and α‐amylase produces dry instant beverage powders with enhanced yield and nutritional properties
Authors: Silvestre‐De‐León Robinzon , Espinosa‐Ramírez Johanan , Pérez‐Carrillo Esther , Serna‐Saldívar Sergio O. 
Published: June 2021

SummaryInstant beverage powders were obtained by sequential alcalase and α‐amylase catalysis of raw or extruded chickpea flours. Chemical composition, solid yield and nutritional properties in terms of oligosaccharides, fatty acids and protein quality were determined. The beverage powder produced with extruded flour (ECF‐S) had adequate protein (20%), hydrolysed starch (48%) and fat (4%) contents. The instant powder yield of ECF‐S was 64% being 2.2 times higher compared with the counterpart obtained from the raw flour (RCF‐S). ECF‐S had higher oligosaccharides compared with RCF‐S, and an oil composition with high proportion of linoleic and oleic acids. In addition, it had an in vitro protein digestibility of 83.1% and protein digestibility‐corrected amino acid score of 0.831. Unflavoured beverages produced with ECF‐S presented improved suspension stability. Hence, thermo‐extrusion followed by biocatalysis with alcalase and α‐amylase proved to be an adequate method to generate higher yields of instant soluble powders suitable for plant‐based consumers, with high nutritional profile. The insoluble coproduct could be valorised into a functional ingredient due to its protein (21%) and hydrolysed starch (16%).
Effect of different milling mechanical forces on the structures and properties of wheat flour
Authors: Tian Xiaoling , Wang Xiaoxi , Ma Sen , Sun Binghua , Qian Xiaojie , Gu Yujuan 
Published: June 2021

SummarySize reduction by milling of endosperm granules produces flour and prompts the heterogeneous distribution of nutrients, changing its properties. The effects of impact milling and frictional milling on the breakage of endosperm granules were evaluated. Comparison of both methods showed that frictional milling initially squeezed larger starch granules out of the endosperm granules, and the flour particles were smaller and exhibited decreased relative crystallinity. Meanwhile, impact milling peeled the protein off the surface of endosperm granules, and the surface of the flour particles had higher S and N contents. Moreover, the content of random coils decreased, and the V‐shaped peak disappeared. The weight loss rate of the ground samples and the maximum thermal cracking temperature of the impact‐milled samples increased significantly as processing progressed. Different milling mechanical forces can be used in combination to obtain the desired flour.
The impact of chitosan film or chitosan/chitosan–epigallocatechin gallate conjugate composite film on the quality changes of Asian sea bass (Lates calcarifer) slices stored in air or under vacuum packaging
Authors: Mittal Ajay , Singh Avtar , Benjakul Soottawat 
Published: June 2021

SummaryQuality and shelf‐life of Asian sea bass slices (ASBS) wrapped with chitosan (CS)/CS–epigallocatechin gallate (CE) conjugate composite or CS films and packaged in air or under vacuum during storage at 4 °C were studied. Total viable count was less than permissible limit (6 log·CFU g−1 sample) for ASBS wrapped with CS/CE conjugate composite film under vacuum (ASBS‐COMP‐VP) after 18 days. Moreover, lower microbial proliferation and volatile base contents were attained in ASBS‐COMP‐VP sample than other samples during the storage (P < 0.05). At the end of storage, ASBS‐COMP‐VP sample had lower lipid oxidation than those wrapped with CS film (P < 0.05). Polyunsaturated fatty acid content of ASBS‐COMP‐VP was retained at higher content at day 18. Therefore, ASBS‐COMP‐VP had the enhanced shelf‐life with high acceptability up to 18 days at 4 °C, while ASBS wrapped with CS film and packaged in air or under vacuum had the shelf‐life of 9 and 12 days, respectively.
The effects of blackcurrant powder (Ribes nigrum) supplementation on pasting properties, physicochemical properties, and nutritive values of starch derived from mung bean (Vigna radiata L.) and pea (Pisum sativum L.)
Authors: Mu Jianlou , Klosek Axelle , Brennan Margaret A. , Chen Zhizhou , Hui Xiaodan , Wu Gang , Brennan Charles S. 
Published: June 2021

SummaryIncorporation of bioactive‐containing fruits and/or vegetables into the carbohydrate‐rich food matrix are effective strategies to develop food products with functional health benefits. In this study, blackcurrant powder was added into pea starch and mung bean starch to form pastes to investigate the effects of blackcurrant powder on physicochemical and nutritional properties of the starch pastes. The predictive in vitro glycaemic response of the pastes was highlighted by in vitro glycaemic glucose equivalent assay and alpha‐amylase inhibitory activity assay. Both assays showed that blackcurrant powder attenuated (P < 0.05) reducing sugar released, through the inhibition of α‐amylase. The colour profiles and textural properties of the pastes were modified by the additions of blackcurrant berry powder at different levels. Nutritional characteristics of the pastes, including total phenolic content and antioxidant activity, were significantly changed (P < 0.05) with the addition of blackcurrant powder.
Is monitoring of antiplatelet therapy by light transmission aggregometry dependent on instrument and reagent used?
Authors: Monteyne Tinne , Heireman Laura , Hemelsoet Dimitri , van Schaik Ron H.N. , Devreese Katrien M.J. 
Published: June 2021

AbstractIntroductionLight transmission aggregometry (LTA), used to detect clopidogrel resistance in patients under antiplatelet therapy, is prone to multiple variables potentially influencing results and interpretation. Currently, no attention is given to type of aggregometer or reagent used. The aim of this study was to evaluate the interassay variability between two aggregometers (Chronolog700 and TA‐8V), using two different ADP reagents (Chrono‐Par® and Agro‐Bio ADP) in patients under clopidogrel therapy. Additionally, LTA results were correlated to CYP2C19‐polymorphism.MethodsLight transmission aggregometry was performed in 20 healthy individuals and 30 patients using both aggregometers, and applying two different reagents (2.5 and 5 µmol/L). The maximum platelet aggregation (ADPmax), the platelet aggregation at 6 minutes (ADP6min), and the percentage of disaggregation at 6 min (ADP%disaggr) were compared between four applied combinations. Additionally, 23 clopidogrel‐resistant patients according to Chronolog700‐Chrono‐par®ADP reagent analysis were tested for CYP2C19*2 polymorphism.ResultsComparison of the LTA of healthy individuals revealed a significant lower ADPmax, lower ADP6min, and higher ADP%disaggr with the TA‐8V aggregometer compared to Chronolog700, regardless of the reagent. In contrast, LTA results in patients are depending on the reagent, with significant higher ADPmax and ADP6min and lower ADP%disaggr using Chrono‐Par® compared to Agro‐Bio ADP reagent. All intermediate clopidogrel metabolizers (CYP2C19*2 carriers) were correctly classified as clopidogrel resistant using Chrono‐Par®, in contrast to the Agro‐Bio ADP reagent.ConclusionLight transmission aggregometry in clopidogrel‐treated patients is mainly depending on the type of ADP reagent. Comparison of LTA with genotype reveals that the choice of instrument seems less influencing. In contrast, in the healthy individuals, differences could be attributed to the instrument.
A systematic review of measures assessing mental health professionals’ perspectives of recovery
Authors: Gyamfi Naomi , Bhullar Navjot , Islam Md Shahidul , Usher Kim 
Published: June 2021

AbstractRecovery is internationally recognized as a concept to improve the well‐being of consumers. Compared with the numerous measures assessing consumer perspectives of recovery, only a few measures have been developed to assess Mental Health Professionals' (MHPs) perspectives of recovery to inform practice. The present study aims to systematically review the literature to identify existing measures designed to assess MHPs' perspectives of recovery and evaluate their psychometric properties, and the methodological considerations of the design and use of these measures. We searched literature across eight electronic databases: MEDLINE, Web of Science, PsycINFO, PsyArticles, CINAHL, Scopus, EMBASE, and Google scholar. We identified 2631 articles across all databases. Of these, 40 articles met the inclusion criteria, which comprised 14 original measures assessing mental health recovery and 26 articles reassessing the psychometric properties of the original 14 measures. Our results suggested that while there are existing measures for assessing MHPs’ perspectives of recovery, only a few of these measures met standard evaluation criteria for psychometric properties. Specifically, the validation of the identified measures is still in its infancy. For example, the easiness of applying the measures differs among the studies, and only a few of the measures fully involved consumers in the scale development phase. The implication of the findings for future use and development of recovery measures in mental health practice and research are discussed and recommended.
Analytics in developing countries: methods, applications, and the impact on the UN Sustainable Development Goals
Authors: Orhan Cosku Can , Guajardo Mario 
Published: June 2021

AbstractThe growing availability of data coupled with advanced methods and computing power have fostered organizations to adopt business analytics in their decision‐making. Nevertheless, the application of analytics is subject to available resources and capabilities, and, therefore, differs from region to region. Developing countries in particular are exposed to circumstances that can limit the expansion of analytics within their domains. This may prohibit the acceleration of development efforts and, consequently, may result in delays in achieving the United Nations Sustainable Development Goals (UNSDGs) set for 2030. Taking this concern as a starting point, this paper provides the results of a survey on the status of analytics research in developing countries. Through a thorough review and classification of 142 articles published during 2009–2019, we characterize analytics in developing countries along three dimensions. First, we explore the mainstream methodologies appearing in the literature, which range from classic optimization techniques to more recent statistical and machine learning methods. Second, we identify 11 application areas that cover a broad range. Third, we focus on the linkages between the reviewed papers and the 17 UNSDGs. Along this dimension, we establish a connection between the literature and 13 goals, and illustrate how some of these contributions relate to some of the 169 targets set by United Nations. Goals such as gender equality are addressed to either little or no extent by the surveyed literature. Also, the survey reveals no adoption of indicators that are set to track the progress toward the targets.
Characterizing environment‐dependent fracture mechanisms of ceramic matrix composites via digital image correlation
Authors: Bumgardner Clifton H. , Heim Frederick M. , Roache David C. , Price Morgan C. , Deck Christian P. , Li Xiaodong 
Published: June 2021

AbstractHere, we unveil a methodology for a novel assessment of the fracture mechanics of SiC/SiC ceramic matrix composites enabled by in situ stereoscopic digital image correlation to quantify in‐process flexural strain and crack opening displacement measurements. This technique isolates individual cracks on the composite surface as discontinuities in the spatial displacement field and correlates key fracture characteristics with the flexural strain of composite specimens during coupled four‐point bend / hermeticity testing. Fracture was observed along the specimen length, originating at the tensile underside and propagating around the circumference of the tubular specimens with generally uniform spacing. Multiple specimens were also tested after heat treatments to 1200°C in open air, in vacuum, and in helium for 48 h to evaluate the environmental effects on the fracture mechanisms of SiC/SiC composites, which revealed degradation of flexural properties after treatment in open air resulting in brittle failure. Indentation‐based fracture toughness measurements were performed, which confirmed a 25% reduction in toughness after open air heat treatment relative to the other heat treatments. This assessment indicated that significant oxidation may occur within the composites from these heat treatments and suggested that further protection of the composites may be necessary for high‐temperature applications.
Hemostatic powder TC‐325 treatment of malignancy‐related upper gastrointestinal bleeds: International registry outcomes
Authors: Hussein Mohamed , Alzoubaidi Durayd , O'Donnell Michael , de la Serna Alvaro , Bassett Paul , Varbobitis Ioannis , Hengehold Tricia , Ortiz Fernandez‐Sordo Jacobo , Rey Johannes W , Hayee Bu'Hussain , Despott Edward J , Murino Alberto , Graham David , Latorre Melissa , Moreea Sulleman , Boger Phillip , Dunn Jason , Mainie Inder , Mullady Daniel , Early Dayna , Ragunath Krish , Anderson John , Bhandari Pradeep , Goetz Martin , Kiesslich Ralf , Coron Emmanuel , Rodriguez de Santiago Enrique , Gonda Tamas , Gross Seth A , Lovat Laurence B , Haidry Rehan 
Published: June 2021

AbstractBackground and AimUpper gastrointestinal tumors account for 5% of upper gastrointestinal bleeds. These patients are challenging to treat due to the diffuse nature of the neoplastic bleeding lesions, high rebleeding rates, and significant transfusion requirements. TC‐325 (Cook Medical, North Carolina, USA) is a hemostatic powder for gastrointestinal bleeding. The aim of this study was to examine the outcomes of upper gastrointestinal bleeds secondary to tumors treated with Hemospray therapy.MethodsData were prospectively collected on the use of Hemospray from 17 centers. Hemospray was used during emergency endoscopy for upper gastrointestinal bleeds secondary to tumors at the discretion of the endoscopist as a monotherapy, dual therapy with standard hemostatic techniques, or rescue therapy.ResultsOne hundred and five patients with upper gastrointestinal bleeds secondary to tumors were recruited. The median Blatchford score at baseline was 10 (interquartile range [IQR], 7–12). The median Rockall score was 8 (IQR, 7–9). Immediate hemostasis was achieved in 102/105 (97%) patients, 15% of patients had a 30‐day rebleed, 20% of patients died within 30 days (all‐cause mortality). There was a significant improvement in transfusion requirements following treatment (P < 0.001) when comparing the number of units transfused 3 weeks before and after treatment. The mean reduction was one unit per patient.ConclusionsHemospray achieved high rates of immediate hemostasis, with comparable rebleed rates following treatment of tumor‐related upper gastrointestinal bleeds. Hemospray helped in improving transfusion requirements in these patients. This allows for patient stabilization and bridges towards definitive surgery or radiotherapy to treat the underlying tumor.