bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taking Sleeping Pills and the Risk of Chronic Kidney Disease: A Nationwide Population-Based Retrospective Cohort Study
Authors: Liao Chen-Yi , Chung Chi-Hsiang , Lu Kuo-Cheng , Cheng Cheng-Yi , Yang Sung-Sen , Chien Wu-Chien , Wu Chia-Chao 
Published: January 2021

Background: Sleeping disorder has been associated with chronic kidney disease (CKD); however, the correlation between sleeping pills use and CKD has not been investigated in-depth yet. This study elucidated the potential association of sleeping pill use with the risk of CKD and CKD progression to end-stage renal disease (ESRD) requiring dialysis.Methods: This study was based on a population-based cohort that included 209,755 sleeping pill users among 989,753 individuals. After applying the exclusion criteria, 186,654 sleeping pill users and 373,308 nonusers were enrolled to monitor the occurrence of CKD. Using a cumulative daily dose, we analyzed the types of sleeping pills related to the risk of CKD and ESRD. Propensity score matching and analysis using Cox proportional hazards regression were performed with adjustments for sex, age, and comorbidities.Results: Sleeping pill use was related to increased CKD risk after adjusting for underlying comorbidities (adjusted hazard ratio [aHR] = 1.806, 95% confidence interval [CI]: 1.617–2.105, p &lt; 0.001). With the exception of hyperlipidemia, most comorbidities correlated with an increased risk of CKD. Persistent use of sleeping pills after CKD diagnosis increased the risk of concurrent ESRD (aHR = 7.542; 95% CI: 4.267–10.156; p &lt; 0.001). After the subgroup analysis for sleeping pill use, brotizolam (p = 0.046), chlordiazepoxide (p &lt; 0.001), clonazepam (p &lt; 0.001), diazepam (p &lt; 0.001), dormicum (p &lt; 0.001), estazolam (p &lt; 0.001), fludiazepam (p &lt; 0.001), flunitrazepam (p &lt; 0.001), nitrazepam (p &lt; 0.001), trazodone (p &lt; 0.001), zolpidem (p &lt; 0.001), and zopiclone (p &lt; 0.001) were found to have significant correlation with increased CKD risk.Conclusion: Sleeping pill use was related to an increased risk of CKD and ESRD. Further studies are necessary to corroborate these findings.
STAT3 Suppresses Cardiomyocytes Apoptosis in CVB3-Induced Myocarditis Via Survivin
Authors: Wang Qiaoyu , Zhu Qiongjun , Ye Qiaofang , Wang Jiajun , Dong Qianqian , Chen Youran , Wang Minna , Fu Yu , Wu Rongzhou , Wu Tingting 
Published: January 2021

Background: Viral myocarditis (VMC) is a common inflammatory cardiovascular disease with unclear mechanisms, which mainly affects children and adolescents. Apoptosis is the key to CVB3-induced myocarditis, and blocking this process may be beneficial to the therapy of VMC. Hence, this study aimed to explore the protective function of STAT3 on cardiomyocyte apoptosis of VMC and its underlying mechanisms.Methods and Results: In this research, we confirmed that STAT3 was significantly activated in both animal and cell models of VMC. To further clarify what role did STAT3 play in VMC, AG490, an inhibitor of STAT3, was used to suppress p-STAT3. Our results demonstrated that decreased expression of p-STAT3 caused by AG490 significantly aggravated severity of VMC with elevated myocardial inflammation, deteriorative ventricular systolic function and increased mortality. It suggested that STAT3 plays a protective role in VMC. To further identify the anti-apoptosis impact that activated STAT3 made, we constructed lentivirus to regulate the expression of STAT3 in NMCs. We found that up-regulated activated STAT3 attenuated cardiomyocyte apoptosis, but down-regulated one aggravated that, which verified activated STAT3 played an anti-apoptosis role in VMC. Following that, we explored what elements are involved in the anti-apoptotic mechanism of activated STAT3 by using survivin inhibitor YM155. The result showed the anti-apoptotic effect of activated STAT3 does not work in the case of survivin inhibition.Conclusion: Our findings demonstrated STAT3 by targeting survivin alleviated cardiomyocyte apoptosis in CVB3-induced myocarditis.
A Longitudinal Study of T2 Mapping Combined With Diffusion Tensor Imaging to Quantitatively Evaluate Tissue Repair of Rat Skeletal Muscle After Frostbite
Authors: Gao Yue , Lu Zhao , Lyu Xiaohong , Liu Qiang , Pan Shinong 
Published: January 2021

Purpose: T2 mapping and diffusion tensor imaging (DTI) enable the detection of changes in the skeletal muscle microenvironment. We assessed T2 relaxation times, DTI metrics, performed histological characterization of frostbite-induced skeletal muscle injury and repair, and provided diagnostic imaging biomarkers.Design and Methods: Thirty-six Sprague Dawley rats (200 ± 10 g) were obtained. Thirty rats were used for establishing a skeletal muscle frostbite model, and six were untreated controls. Functional MR sequences were performed on rats on days 0, 3, 5, 10, and 14 (n = 6 per time point). Rats were then sacrificed to obtain the quadriceps muscles. Tensor eigenvalues (λ1, λ2, and λ3), mean diffusivity (MD), fractional anisotropy (FA), and T2 values were compared between the frostbite model and control rats. ImageJ was used to measure the extracellular area fraction (EAF), muscle fiber cross-sectional area (fCSA), and skeletal muscle tumor necrosis factor α (TNF-α), and Myod1 expression. The correlation between the histological and imaging parameters of the frostbitten skeletal muscle was evaluated. Kolmogorov–Smirnoff test, Leven’s test, one-way ANOVA, and Spearman coefficient were used for analysis.Results: T2 relaxation time of frostbitten skeletal muscle was higher at all time points (p &lt; 0.01). T2 relaxation time correlated with EAF, and TNF-α and Myod1 expression (r = 0.42, p &lt; 0.05; r = 0.86, p &lt; 0.01; r = 0.84, p &lt; 0.01). The average tensor metrics (MD, λ1, λ2, and λ3) of skeletal muscle at 3 and 5 days of frostbite increased (p &lt; 0.05), and fCSA correlated with λ1, λ2, and λ3, and MD (r = 0.65, p &lt; 0.01; r = 0.48, p &lt; 0.01; r = 0.52, p &lt; 0.01; r = 0.62, p &lt; 0.01).Conclusion: T2 mapping and DTI imaging detect frostbite-induced skeletal muscle injury early. This combined approach can quantitatively assess skeletal muscle repair and regeneration within 2 weeks of frostbite. Imaging biomarkers for the diagnosis of frostbite were suggested.
KESELARASAN DISIPLIN, PROMOSI KREATIF DAN KUALITAS LAYANAN MENINGKATKAN MOTIVASI KERJA PADA PT ASURANSI BANGUN ASKRIDA JAKARTA
Authors: Utomo Kurniawan Prambudi , Supriyanto Supriyanto , Winardi N Muhammad Aziz 
Published: January 2021

Penelitian ini menjelaskan tentang pengaruh dan hubungan disiplin dan promosi kreatif dalam meningkatkan motivasi kerja karyawan PT Askrida Jakarta dalam mempertahankan jumlah nasabah dan memperluaskan jangkauan produk, adapun tujuan penelitian untuk menguji pengaruh dan hubungan antara variabel dan nilai korelasinya dengan metode penelitian secara kuantitatif serta jumlah responden sebanyak 100 karyawan dalam jangka waktu enam bulan yaitu Januari hingga Juni 2019, dan hasil penelitian menunjukan bahwa antar variabel menunjukan nilai positif dan signifikan, juga untuk uji statistik menjelaskan hasil yang cukup baik sehingga perlu meningkatkan motivasi kerja dengan terus meningkatkan disiplin dan berpromosi secara kreatif di PT Asuransi Bangun Askrida Jakarta agar dapat meningkatkan keuntungan perusahaan dan tetap menjaga kesejahteraan karyawan dan menjaga kepuasan nasabah.
Kata kunci: disiplin, promosi kreatif, motivasi.
ANALISIS PENGARUH RASIO KEUANGAN TERHADAP HARGA SAHAM PADA PERUSAHAAN PERKEBUNAN YANG TERCATAT DI BURSA EFEK INDONESIA
Authors: Aranza Naufal Bintang , Sulistyowati Lies 
Published: January 2021

The purpose of this study to investigate the effect of financial ratio on the stock price of plantation companies listed in Indonesia Stock Exchange. The research method used the associative method in a casual relationship form. The study used an annual report from 14 plantation companies listed in Indonesia Stock Exchange during the period 2014 to 2018 as the study sample. Data method analysis in the study used regression data panel analysis with the fixed-effect model. The result shows that the debt to equity ratio has a significant effect on stock price, whereas the current ratio, return on asset, and the price-earnings ratio has an effect but not significant on stock price from plantation companies. The researcher suggested that investors pay attention to the debt to equity ratio before investing in plantation companies because this ratio can show the investment risk of the company.
Keywords: Financial Ratio, Stock Price, Plantation

Penelitian ini bertujuan untuk menganalisa pengaruh dari rasio keuangan terhadap harga saham dari perusahaan perkebunan yang tercatat di Bursa Efek Indonesia. Metode penelitian yang digunakan merupakan metode asosiatif dalam bentuk hubungan kausal. Penelitian menggunakan laporan tahunan dari 14 perusahaan perkebunan yang tercatat di Bursa Efek Indonesia dalam periode 2014-2018 sebagai sampel penelitian. Metode analisa data yang digunakan adalah analisis regresi data panel dengan model fixed effect. Hasil penelitian menunjukan bahwa debt to equity ratio memiliki pengaruh yang signifikan terhadap harga saham, sedangkan untuk current ratio, return on asset, dan price earning ratio tidak memiliki pengaruh signifikan terhadap harga saham dari perusahaan perkebunan. Peneliti menganjurkan kepada investor agar memperhatikan debt to equity ratio sebelum berinvestasi di perusahaan perkebunan karena rasio tersebut dapat memperlihatkan risiko investasi dari perusahaan.
Kata Kunci: Harga Saham, Perkebunan, Rasio Keuangan
FAKTOR MAKROEKONOMI TERHADAP INDEKS HARGA SAHAM SUBSEKTOR KEUANGAN YANG TERDAFTAR DI BEI
Authors: Sari Titis Nistia , Zatira Dhea , Ganika Gerry 
Published: January 2021

This article is to examine the effect of the BI Rate, Inflation and Exchange Rates on the stock price indexes of the financial sub-sectors listed on the Indonesia Stock Exchange in the period November 2015 to October 2019. Data analysis techniques used in this study are regression models with quantitative methods. Test results prove that the negative BI Rate for IHSK and H1 is accepted. Negative inflation in FSPI and H2 is accepted. Positive exchange rates on the IHSK and H3 are accepted. The BI Rate, Inflation, and Exchange Rates received simultaneously against IHSK and H4 are accepted. The magnitude of the effect on R squared was 54.6%, while the remaining 45.4% was accepted by other variables not approved in this study.
Keywords: BI Rate, Inflation, Exchange Rates, Financial sub-sector Stock Price Index (FSPI)

Artikel ini adalah untuk memeriksa dampak suku bunga BI, nilai inflasi dan nilai tukar, terhadap harga harga dibursa saham pada sub sector keuangan yang terdaftar di bursa saham Indonesia untuk periode November 2015 sampai dengan Oktober 2019, tehnik penganalisaaan data yang digunakan pada studi ini adalah model mundur dengan metode kuantitatif. Hasil tesnya membuktikan bahwa suku bunga negatif BI untuk IHSK dan H1 dapat diterima. Inflasi negatif pada FSPI dan H2, dapat diterima.Nilai tukar yang positif pada IHSK dan H3 dapat diterima. Suku bunga BI, inflasi dan nilai tukar yang diterima secara berkesinambungan terhadap IHSK dan H4 dapat diterima. Daya Tarik dari dampak pada kotak R adalah 54.6% sementara sisanya yang 45.4% diterima oleh variabel lain yang tidak dibahas pada studi ini.
Kata Kunci: Suku Bunga BI, Inflasi, Nilai Tukar, Indeks Harga Saham sub sektor Keuangan (IHSK)
A escrita no contexto universitário:
Authors: Bomfante Záira , Rita de Cassia Cristofoleti  
Published: January 2021

Diversos são os trabalhos que têm proposto, no contexto atual, a discussão da leitura e escrita no espaço universitário, buscando compreender o processo de apropriação da palavra de outrem. Nesse trabalho, agasalhamos concepção de escrita como um processo em que os alunos são formados para a pesquisa, situando-se num processo de agenciamento de escrita de pesquisa em formação. Assim, procuraremos traçar uma contextualização da importância epistemológica da concepção sociossemiótica e da concepção de letramento e suas implicações para o contexto acadêmico. Trazemos uma discussão sobre a escrita no espaço universitário, vinculando a discussão a partir de nossa experiência de ensino e pesquisa desenvolvida em programa institucional de apoio acadêmico à alunos de graduação. Nessa direção, indicamos os projetos de letramento como alternativa para o desenvolvimento de um trabalho contextualizado com os gêneros discursivos.
Definições de termos técnico-científicos do domínio da linguística em dicionários gerais
Authors: Nascimento Monteiro Beatrice , Cardoso Alves Ismael Paulo 
Published: January 2021

A Lexicografia é uma área que tem se expandido de maneira intensa nos últimos anos. Inserido nesse viés de análise de obras lexicográficas, o presente artigo volta-se para um subconjunto do léxico geral: os itens terminológicos, mais especificamente, termos do domínio da Linguística. Tomando, como corpus, dicionários gerais, objetivamos examinar as definições de termos técnico-científicos nessas obras, analisando a sistematicidade da inclusão de tais termos bem como a adequação e detalhamentos dos textos definitórios. A discussão teórica apresentada é fundamentada principalmente em Biderman (2001), Krieger (2007) e (2011), Almeida (2011), Maciel (2011), entre outros. Os dicionários gerais analisados foram: Houaiss (eletrônico), Novíssimo Aulete e Aurélio. Selecionamos, para a análise, cinco itens lexicais que comportam tanto acepções mais gerais quanto específicas do domínio da Linguística. Os itens selecionados foram: língua, fala, texto, discurso e gênero. Como resultado, constatamos que os dicionários, muitas vezes, desconsideraram a polissemia dos itens lexicais, abarcando tão somente as acepções de uso corriqueiro das palavras, sem fazer menção a seu uso específico na área da Linguística.
Memorial do Holocausto
Authors: Teixeira Maria Cláudia , Baldissera Raquel 
Published: January 2021

O presente artigo apresenta a análise de quatro texto-imagens, parte do projeto artístico intitulado Yolocaust, referente ao Memorial aos Judeus Mortos da Europa ou Memorial do Holocausto (Holocaust-Mahnmal). As quatro materialidades tomadas como corpus são de autoria do artista Shahak Shapira, que ressignifica fotografias tiradas por turistas no Memorial do Holocausto e usadas em perfis das redes sociais. O objetivo é mostrar como se instauram efeitos de sentidos sobre a memória e o esquecimento. Para isso, tomamos como fundamentação teórica a Análise de Discurso de linha francesa do filósofo francês Michel Pêcheux e as implementações desenvolvidas pela brasileira Eni Orlandi. Os resutados obtidos mostram que ao ressignificar as imagens o sujeito artista materializa a memória do holocaust, dos campos de concentração, através da realização do projeto “Yolocaust”, produzindo um efeito de conscientização histórica ao produzir a materialização do atravessamento entre o intra e o interdiscurso.
High field-effect mobility with suppressed negative threshold voltage shift in 4H-SiC MOSFET with cerium oxide interfacial layer
Authors: Song Jinhan , Ohta Atsuhiro , Hoshii Takuya , Wakabayashi Hitoshi , Tsutsui Kazuo , Kakushima Kuniyuki 
Published: January 2021

Abstract
Enhanced oxidation of the 4H-SiC surface in an oxygen-lean environment by a thin CeO
x
layer was confirmed. By capping with a 40 nm thick SiO2 layer on a 1 nm thick CeO
x
layer, the formation of the interfacial SiO2 layer was suppressed, and the growth of the capped SiO2 layer was observed instead. A high peak field mobility of 54 cm2 V−1 s−1 was obtained with the structure, which is higher than the commonly used thermally grown SiO2 layer with NO-based high-temperature annealing. Moreover, the threshold voltage kept higher than 2 V, which has an advantage over other mobility enhancement gate oxide formation processes.
Neutron detection via thermoluminescence of Tb3+-doped Li2O–Al2O3–B2O3glasses
Authors: Kawamura Ichiro , Kawamoto Hiroki , Fujimoto Yutaka , Koshimizu Masanori , Okada Go , Wakabayashi Genichiro , Nogami Mitsuhiro , Hitomi Keitaro , Watanabe Kenichi , Yanagida Takayuki , Asai Keisuke 
Published: January 2021

AbstractWe fabricated Tb3+-doped Li2O–Al2O3–B2O3glasses using6Li ornLi and10B or11B (6Li–10B glass,6Li–11B glass,nLi–10B glass, andnLi–11B glass) to develop a new thermoluminescent (TL) material for neutron detection and investigated the TL properties of these glasses after X-ray, He ion, and neutron irradiation. TL glow peaks were observed at 350 and 550 K after X-ray irradiation, at 390 and 550 K after He ion irradiation, and at 400 and 600 K after neutron irradiation. The TL intensities around 400 K for6Li–10B glass,6Li–11B glass, andnLi–10B glass after neutron irradiation were higher than that ofnLi–11B glass, suggesting that the particles generated in6Li(n,t)4He and10B(n,α)7Li reactions efficiently induce TL. We observed neutron-induced TL in the range 1 × 107–5 × 108neutrons cm−2, and the detectable minimum thermal neutron fluence of this glass was estimated to be approximately 4 × 106neutrons cm−2.
Double-frequency metallic grating over large areas with ultrahigh Raman enhancement
Authors: Li Wenxue , Fang Longjie , Dai Yixin , Pang Lin 
Published: January 2021

Abstract
Raman spectroscopy reveals molecular vibration and rotation modes and directly reflects the molecular structure of analytes. Surface enhanced Raman spectroscopy may be applied to practical applications because of the greater Raman scattering cross section. This paper proposes and demonstrates a large-area double frequency metallic grating based on surface enhanced Raman scattering substrate which is cost effective. By exciting two coupled resonance modes, a strong local electromagnetic field was formed. The Raman enhancement factor up to 108 and the minimum detectable concentration down to 10−15 M were achieved.
Socio-economic aspects of the use of innovative technologies in the production of bakery, pasta and confectionery products
Authors: Filatov V. V. , Bulavina T. A. 
Published: January 2021

This article reviews Russian industry experience in developing innovative technologies in the production of bakery, pasta, and confectionery products. The article analyzes innovative technologies developed in Russian institutes, universities, and enterprises of the bakery, pasta, and confectionery industries, in particular the state research Institute of Agriculture, Kuban State Technological University, Belgorod University of consumer cooperation, and Moscow state University of technology and management named after K. G. Razumovsky University (PKU), Moscow State University of food production. It is established that the state order system is focused on purchasing products at low prices and weakly encourages the introduction of innovative technologies into production. The main vectors of innovative transformations of bakery enterprises in the Russian Federation are the use of stoves, dough mixers, mixers, and non-traditional raw materials in the production of bakery products in order to increase the content of essential nutrients, improve the balance of essential essential nutrients, improve the quality and shelf life of finished products, and provide products with a functional orientation, which generally corresponds to global trends five years ago. Currently, consumers of bakery, pasta and confectionery products want to see in these products something more than sweetness, taste and aroma, they need confidence that the products will not cause harm to health, so one of the tasks set for technologists is to develop innovative products not only to expand the range, but also to improve the nutritional value of products.
Productivity of soya crops under application of different types of fungicides and inoculant
Authors: Mostoviak I. , Kravchenko O. 
Published: January 2021

Goal. Fungicide application fungicides, applied separately and at the background of using inoculum Rhizoactive, on the formation of yielding capacity and some structural parameters of soy crops. According to the set goal, the task was to select the most effective fungicides to fight diseases in the crops, when they are applied separately and at the background of seed inoculation with Rhizoactive.
Methods. Field and laboratory.
Results. It has been established that the formation of the yielding capacity of soya and indexes of crops structure depends on the fungicides type and their application against the background of using inoculant and without it. It has been proved that the highest productivity of soya crops formed in the variants of the experiment with the application of Impact K, 0.8 l/ ha and Coronet 300 SC КС, 0.8 l/ha against the background of treatment of soya seeds with Rhizoactive.
Conclusions. Application of fungicides Akanto Plus 28 KC, 1.0 l/ha, Amistar Extra 280 SC, KC, 0.75 l/ha, Bamper Super 490, KE, 1.5 l/ ha, Impact K, 0.8 l/ha, Koronet 300 SC, KC, 0.5 l/ha in the crops of soy at the background of pre-sowing seed treatment with inoculum leads to the increase of yielding capacity of crops by 11—15% and improved structure of crops, which is, on the one hand, provided by the improving phytosanitary state of soy crops under the action of fungicides, and on the other hand, by the nutrition of plants at the background of activation of legume inoculum.
Brings Reality Through Virtual Reality
Authors: Anggraini Sazkia Noor 
Published: January 2021

Film festival is a place to convey specific film for specific purposes. Festival nowadays were broaden their medium, not only on screen but also involved more audience with new technology mobile devices. As the longest running documentary film festival in Indonesia, Festival Film Dokumenter (FFD) have been concern about the impact of film screenings to the audience. Since 2016, FFD have been intend to using several medium to convey disability rights awareness. FFD conducted the program Virtual Reality (2016) and The Feelings of Reality (2018). Both of those program were using Virtual Reality (VR) technology during the festival showcase. In 2016 program, the audience even placed in the replica setting to have a similar situation with people with epilepsy.
VR is the new attempt to brings the new documentary experience. This technology lead the impression of reality to the audience. VR known as a device that can enhance the audience cinematic experience. In documentary filmmaking, which always closely associated with the depiction of reality - in a way, the VR technology can provide different perspective on perceiving documentary. In documentary screenings, VR have a powerful strength on bringing the reliable reality which closer to the audience.
Festival offers the discourse on watching the documentary into experiencing the documentary using VR. This paper will discuss about how festival provide alternative medium to present disability issue to the public. Vice versa, how audience raised their awareness through VR technology. This study conducted in qualitative impact study that focused on in-depth interview with both festival organizer/programmer and audience. This study found out that VR technology identically constructed the reality. This method is the most effective way to raising the awareness because people would feel how to live with disability closely and clearly. Rather than just watching a film, experiencing disability through VR prove a different impression to the audience. By presenting the actual condition of people with disability, VR succeed to give more heightened impact and awareness on this issue.