bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Supportive Supervisory Scale: Psychometric Properties in Chinese Health Care Aides Samples
Authors: Tian Li , Li Haixia , Dong Bei , Xie Congyan , Wang Hong , Lin Lu 
Published: January 2021

Abstract
Objective: To sinicize the Supportive Supervisory Scale (SSS) and analyze the psychometric properties of the Chinese version of SSS (SSS-C).Methods: The SSS (the original English version) was firstly sinicized and adjusted, then its psychometric properties were examined in 300 health care aides from four long-term care (LTC) facilities. SPSS 22.0 was used to process the data and calculate the reliability and validity. Results The 15-item SSS-C had satisfactory internal consistency (Cronbach’s α coefficient=0.852), split half reliability (Spearman-Brown coefficient=0.834) and test-retest reliability (Pearson correlation coefficient=0.784), and three factors were extracted. If the four items with their communality <0.4 were deleted, the remaining 11 items could explain 55.654% of the total variance. The discriminant validity of the SSS-C varied significantly between sites.Conclusions The Chinese version of SSS can be used to effectively measure the supervisory support of the nurses within the LTC settings.
How Well Do Documented Goals-of-Care Discussions for Patients with Stage IV Cancer Reflect Communication Best Practices?
Authors: Ernecoff Natalie C. , Wessell Kathryn L. , Wood William A. , Winzelberg Gary S. , Collichio Frances A. , Hanson Laura C. 
Published: January 2021

Abstract
Background: Written clinical communication regarding patients’ disease understanding and values may facilitate goal-concordant care, yet little is known about electronic health record (EHR) goals-of-care documentation. We sought to (1) describe frequency of communication best practices in EHR-documented goals-of-care discussions, and (2) assess whether templated notes improve quality of documentation.Methods: We abstracted all EHR-documented goals-of-care discussions for hospitalized patients with Stage IV cancer from admission to 60-days follow-up. Goals-of-care documentation was operationalized to include discussion of: (a) prognosis and/or illness understanding; and (b) goals and/or treatment options. Investigators qualitatively coded text based on conceptual frameworks for communication best practices, including decision making documentation, and noted if a health system template was used. Results: Among 206 of 492 (42%) patients with documented goals-of-care discussions, clinicians frequently communicated cancer progression or incurability (89%), but rarely addressed prognosis for life expectancy (22%). Goals and values were documented for 83%, and a treatment decision for 82% of patients. Treatment preferences were assessed for 98% of patients; options discussed included cancer treatment (62%), hospice (62%), resuscitation (51%), or intensive care (38%). Clinicians made a treatment recommendation for 40% of patients. Attention to emotional and spiritual concerns was uncommon (15%). Use of a template increased documentation of patient goals and values (80% vs. 61%, p<0.01), but did not enhance other communication best practices.Conclusion: Insights from the study can be used to guide future training and research to study and improve the quality of written communication about goal of care, and its impact on goal-concordant care.
Polyparasitism with Schistosoma haematobium,Plasmodium and soil-transmitted helminths in school-aged children in Muyuka-Cameroon following implementation of control measures: a cross sectional study
Authors: Sumbele Irene Ule Ngole , Otia Ofon Vitalis , Bopda Orelien Sylvain Mtopi , Ebai Calvin Bisong , Kimbi Helen KuoKuo , Nkuo-Akenji Theresa 
Published: January 2021

Abstract
Background: Despite the ubiquity of polyparasitism, its health impacts have been inadequately studied. The aim of this study was to determine the prevalence and determinants of polyparasitism with Schistosoma haematobium, Plasmodium and soil-transmitted helminths (STH) following sustained control measures, as well as evaluate the outcomes and clinical correlates of infection in school-aged children (SAC) living in the schistosomiasis endemic focus of Muyuka-Cameroon.Methods: In a cross-sectional study, urine, blood and stool samples were each collected from SAC (4–14 years) selected at random between March to June 2015. Microhaematuria in urine was detected using reagent strip and S. haematobium ova by filtration/microscopy methods. Plasmodium was detected using Giemsa-stained blood films and complete blood count was obtained using an auto-haematology analyser. STH in stool was detected by the Kato-Katz method. Categorical and continuous variables were compared as required, Kappa value estimated and the adjusted odds ratio (aOR) in the multivariate analysis was used to evaluate association of the risk factors with infection.Results: Out of the 638 SAC examined, single infection was prevalent in 33.4% while polyparasitism was 19.9%. Prevalence of S. haematobium + Plasmodium was 7.8%; S. haematobium + STH was 0.8%; Plasmodium + STH was 0.8%; while S. haematobium + Plasmodium + STH was 0.9%. Higher preponderance of S. haematobium + Plasmodium infection occurred in females, those from Likoko, did not use potable water, practiced bathing in stream and carried out open defecation than their equivalents. However, being female (aOR =2.38, P = 0.009) was the only significant risk factor identified. Anaemia was a common morbidity (74.3%) with a slight agreement with microscopy in predicting S. haematobium and Plasmodium infections. The sensitivity and specificity of haematuria (13.0%) in predicting S. haematobium infection was 46.5% and 100% with a moderate agreement with microscopy. Co-infection with S. haematobium and malaria parasite was significantly associated with 3-fold odds of history of fever in the last three days.Conclusions: Polyparasitism is a public health problem in Muyuka with females most at risk. Anaemia prevalence is exacerbated in co- and triple-infections and together with a history of fever are of value in predicting polyparasitism.
Measurement and Prediction of Short-Range Path Loss between 27 and 40 GHz in University Campus Scenarios
Authors: Ramos Glaucio , Vargas Carlos , Mello Luiz , Pereira Paulo , Vieira Robson , Gonçalves Sandro , Rego Cássio 
Published: January 2021

Abstract
In this paper, we present the results of short-range path loss measurement in the microwave and millimetre wave bands, at frequencies between 27 and 40 GHz, obtained in a campaign inside a university campus in Rio de Janeiro, Brazil. Existing empirical path loss prediction models, including the alpha-beta-gamma (ABG) model and the close-in free space reference distance with frequency-dependent path loss exponent (CIF) model, are tested against the measured data, and an improved prediction method that includes the path loss dependence on the height diﬀerence between transmitter and receiver is proposed. The main contribution of this paper is the use of the Fuzzy technique to perform path loss predictions for short links in the millimetre wave range, from 27 to 40 GHz, providing lower errors when compared to the traditional ABG and CIF models. However, it should be noted that the Fuzzy technique uses a set of equations to perform the prediction and the attenuation coeﬃcient is not explicit as in the classical models. Also, a non-negligible correlation between the diﬀerence in height between transmitter and receiver positions and the path loss in such short links (i.e., the path inclination) has been observed and requires further investigation. If conﬁrmed, it could provide an additional parameter to improve the accuracy of the traditional ABG model.
In situ acoustic analysis of two 20th-century heritage carillons
Authors: Orr Scott Allan 
Published: January 2021

Abstract
Carillons are a diverse and global form of musical and civic heritage: musical instruments comprised of a series of 23 or more bells, typically hung in a tower-like structure, tuned chromatically and played from a touch-sensitive manual and pedal console using an elaborate mechanical action. Carillon bells have a distinct series of musical overtones which should be accurately tuned to one another and with other bells they sound alongside. Although these overtones have been previously studied ex situ, this study assesses the acoustic characteristics of two early-20th century carillons in Toronto, Canada as a combination of structure, bells, and mechanical action. Thus, the instrument and its context are considered holistically, more accurately reﬂecting the musical sensitivity of a carillonist. Spectral analysis of audio samples of each bell at diﬀerent musical dynamic levels enabled the analysis of the acoustic qualities of the bells and the mechanical action of the instruments. The tuning of bells in the instruments varied; most importantly, there was a signiﬁcant diﬀerence between the audial intensity of the bell tones produced by the instruments, demonstrating the importance of the mechanical action as part of the ‘carillon system’. This was represented with a resistive power-law model, that represents the sensitivity of intensity to carillonist musical dynamic level. A discussion of the implications for artistic and heritage practice follows. Understanding the in situ physical acoustics of the carillon as a holistic instrument in its context informs performers, arrangers, and composers of how they can best embrace the instrument’s unique qualities to improve artistic pursuits and support the appreciation of carillons as heritage instruments and function as civic voices.
Airborne particulate matter (PM2.5) triggers ocular hypertension through pyroptosis
Authors: Li Liping , Xing Chao , Niu Liangliang , Luo Bin , Zhou Ji , Song Maomao , Niu Jingping , Ruan Ye , Sun Xinghuai , Lei Yuan 
Published: January 2021

Abstract
Background Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused on the ocular surface, with limited research on the impact of PM2.5 on intraocular pressure (IOP).Methods To investigate the impact of PM2.5 on IOP and the associated mechanism, C57BL/6 mouse eyes were topically exposed to a PM2.5 suspension for 3 months, and human trabecular meshwork (HTM) cells were subjected to various PM2.5 concentrations in vitro.Results The results revealed that the IOP increased gradually after PM2.5 exposure, and an upregulation of NLRP3 inflammasome, caspase-1, IL-1β, and GSDMD protein levels was observed in outflow tissues. PM2.5 exposure decreased HTM cell viability and affected contraction. Further, elevated ROS levels were observed as well as an activation of the NLRP3 inflammasome and downstream inflammatory factors caspase-1 and IL-1β. ROS scavenger or caspase-1 inhibitor treatment improved these PM2.5-induced changes.Conclusion This study provides novel evidence of the PM2.5-mediated development of ocular hypertension, which occurs as a result of increased oxidative stress and the subsequent induction of pyroptosis in trabecular meshwork cells.
Pt/CeO2 with residual chloride as reusable soft Lewis acid catalysts: application to highly efficient isomerization of allylic esters
Authors: Huang Qi-An , Haruta Asahi , Kumamoto Yuhya , Murayama Haruno , Yamamoto Eiji , Honma Tetsuo , Okumura Mitsutaka , Nobutou Hiroki , Tokunaga Makoto 
Published: January 2021

Abstract
Heterogeneous acid and base catalysts play a crucial role in many important chemical processes. Hard Lewis and Brønsted acid catalysts like silica-alumina and zeolites have been widely applied in numerous reactions; however, developing reusable and active soft Lewis acid catalysts remain a challenge. Herein, we demonstrate for the first time that a highly dispersed supported platinum catalyst can act as a heterogeneous soft Lewis acid. High turnover numbers and reusability were observed in the isomerization of allylic esters under solvent-free conditions. Moreover, the as-prepared catalysts are characterized by X-ray photoelectron spectroscopy (XPS) and X-ray absorption fine structure (XAFS) analyses, revealing that the highly dispersed Pt clusters with Pt–Cl bonds play a key role in the high activity. The residual chloride anion enhances the Lewis acidity of the Pt metal center and thus improves the catalytic activity. Simultaneously, the high catalytic activity of Pt/CeO2 with residual chloride and the soft Lewis acid mechanism are also proved by density functional theory (DFT) calculations based on the model reaction.
Suprasegmental Features of Indonesian Students’ English Pronunciation and the Pedagogical Implication
Authors: Suciati Suciati , Diyanti Yuniar 
Published: January 2021

This minor study aims at describing learners’ features of pronunciation in terms of their suprasegmental aspects found in their speech. Students were asked to read aloud a text entitled The Gorilla Joke from the © BBC British Council 2006. Students oral narrations were then analysed in terms of their intonation pattern and stress assignment in sentence level. A metrical analysis was also used to show how students produced their speech rhythm. The result of the analysis shows that given the same text to read students may produce various combination of intonation patterns. Students also misplaced stress within the syllables or assigned no stress at all. Based on the metrical phonology analysis, learners did not assign foot timely based on the timing units in connected speeches. The speech production is more like a broken speech. Students also neglected the morphophonemics rules in which they did not produce the appropriate allomorphs [t], [d], and [id] in the past participle words. These features bring about some pedagogical implication.
Keywords: student’ pronunciation features, suprasegmental aspects
NAD Precursors, Mitochondria Targeting Compounds and ADP-Ribosylation
Inhibitors in Treatment of Inflammatory Diseases and
Cancer
Authors: Poltronieri Palmiro , Mezzolla Valeria , Farooqi Ammad Ahmad , Di Girolamo Maria 
Published: January 2021

:
Mitochondrial dysfunction and oxidative stress are prominent features of a
plethora of human disorders. Dysregulation of mitochondrial functions represents a common
pathogenic mechanism of diseases such as neurodegenerative disorders and cancer.
The maintenance of the Nicotinamide adenine dinucleotide (NAD+) pool, and a positive
NAD+/NADH ratio, are essential for mitochondrial and cell functions. The synthesis and
degradation of NAD+ and transport of its key intermediates among cell compartments
play an important role in maintaining optimal NAD levels, for the regulation of NAD+-utilizing
enzymes, such as sirtuins (Sirt), poly-ADP-ribose polymerases, and CD38/157 enzymes,
either intracellularly as well as extracellularly. In this review, we present and discuss
the links between NAD+, NAD+-consuming enzymes, mitochondria functions, and
diseases. Attempts to treat various diseases with supplementation of NAD+ cycling intermediates
and inhibitors of sirtuins and ADP-ribosyl transferases may highlight a possible
therapeutic approach for therapy of cancer and neurodegenerative diseases.
Fine Tuning of Intracellular Ca2+ Content by Pharmacological Agents – A Strategy to Prevent Synapse Loss in Alzheimer Disease Hippocampal Neurons
Authors: Popugaeva Elena 
Published: January 2021

:
Alzheimer disease is the dominant form of elderly dementia. Today all clinical trials that
target β-amyloid have failed to indicate that β-amyloid may not be a causative agent in AD pathogenesis.
Thus there is a need to search for alternative ways to treat AD patients.

:
Neuronal store-operated calcium entry is a fine-tuning mechanism that regulates intracellular Ca2+
content. Recent evidence suggests that store-operated calcium channels may be targeted with pharmacological
agents in order to prevent synapse loss, recover long-term potentiation and change behavior.

:
Current mini-review discusses basic chemical structures that modulate intracellular calcium dysbalance
via targeting store-operated calcium channels and their applicability as anti-AD pharmacological
agents.
Study and Determination of Aluminum in Dextran 40 Glucose Injection by ICP-MS
Authors: Liu Ji-Wu , Zheng Jin-Qi , Zhu Si-Qi , Gu Xiao , Zhu Pei-Xi 
Published: January 2021

Background:
Aluminum (Al) is classified as other elements by ICH, and its permitted
daily exposure (PDE) has not been established. As it might cause compromised renal function,
guidelines, regional regulations and practices need to be addressed. According to the United States
Pharmacopeia 41 and the Japanese Pharmacopoeia 17, the aluminum content of large-volume parenterals
(LVPs) used in total parenteral nutrition (TPN) therapy must not exceed 25 ng mL-1. Therefore,
the package insert of LVPs used in TPN therapy must state the content of aluminum.

Objective:
A new microwave assisted acid digestion pretreatment together with inductively coupled
plasma mass spectrometry (ICP-MS) method was developed for the determination of aluminum
content in Dextran 40 Glucose Injection. The method was successfully applied for quality
evaluation of commercial Dextran 40 Glucose Injection.

Methods:
Samples were digested by a mixture of nitric acid and hydrochloric acid, with the assistance
of microwave. After that, ICP-MS in KED mode was employed to analyze the samples.

Results:
The method showed a good linearity (r2=0.9999) within the range of 2~100 ng mL-1,
with the limit of detection and quantitation of 0.482 ng mL-1 and 1.61 ng mL-1, respectively. A
good precision was obtained with relative standard deviation (RSD) of 8.8% (n=6). The spike recoveries
with low, middle and high Al content in 9 sample were 102.2%~107.4%.

Conclusion:
The developed method was successfully applied for the analysis of Al content in 44
batches of Dextran 40 Glucose Injection produced by 9 pharmaceutical companies from domestic
or international enterprises. The Al content of Dextran 40 Glucose Injection varied greatly
between different enterprises or different batches. Meanwhile, among total of 44 batches, the Al
content in 3 batches of Dextran 40 Glucose Injection exceeded the limitation of 25 ng mL-1,
which might cause potential safety problems.
Negative Correlation between Neuregulin-4 and IL-9 Serum Levels in Patients with Coronary Artery Disease
Authors: Farshidi Hossein , Naderi Nadereh , Montazerghaem Hossein , Farshidi Narges , Rahimzadeh Mahsa 
Published: January 2021

Background:
Neuregulin 4 (Nrg4) is a novel adipocytokine which has been proposed to play a role in modulating
energy metabolism and pathogeneses of atherosclerosis. However, no published research is available about the mechanisms
underlying the anti-atherosclerotic effect of Nrg4. Regarding the close link between adipocytokines and immune system,
we wonder whether there is a relation between Nrg4 and athero-protective cytokines. The aim of this study was to
investigate the relationship between serum Nrg4 levels and type 2 cytokines in Iranian patients with coronary artery disease
(CAD).

Methods:
In this case-control study, 125 CAD patients were compared to 55 healthy controls. Serum concentration of Nrg4,
IL-5, IL-9 and IL-13 were measured using ELISA. The associations of circulating Nrg4 and IL-5, IL-9, IL-13 were assessed
using linear regression analyses.

Results:
Serum concentration of IL-9 was significantly higher in patients compared to the healthy controls (317.9±139
versus 228.3±99.1, P= ˂0.0001). IL-13 and Nrg4 were significantly lower in patients compared to the healthy controls
(4.3±3.7 versus 6.1±3.9, P=0.01 and 0.5 versus 1.3, P=0.001 respectively). Multiple linear regression analyses revealed that
IL-9 was negatively correlated with Nrg4 (β= -0.3, P=0.009).

Conclusion:
Our study ،for the first-time, provides the clinical evidence revealing that circulating Nrg4 concentrations are
inversely correlated with IL-9 in Iranian patients with CAD, suggesting that the protective role of Nrg4 on atherosclerosis
may be, in part, mediated by the proatherogenic cytokine, IL-9.
Effect of HCl Concentration and Acetone Washing on the Dielectric and Conduction Properties of Polyaniline Salts
Authors: Mohanty Jayashree , Mishra S.R. , Badapanda Tanmaya , Anwar S. 
Published: January 2021

Background:
In order to know the effect of acid concentration, comparative
electrical properties of PANI salt samples prepared in two different media like water,
1M HCl and 2M HCl, have been studied.

Methods:
To know the effect of acetone washing on the electrical behavior of the polymer,
the polymer samples were washed with acetone. The X-ray diffraction pattern
shows a crystalline nature of all the prepared PANI salt samples except non-acetone
washed PANI salt prepared in 2M HCl. The SEM micrograph suggests a uniform and
continuous morphology for PANI salts prepared in 1M HCl, agglomerated granulated
structure for PANI salts prepared in 1M HCL, and fiber type structure for PANI salts
prepared in 2M HCl.

Results:
The study showed that the dielectric constant decreases with frequency in the
case of all the synthesized polymer samples. The variation of AC conductivity of the
synthesized polymer samples with respect to the frequency at room temperature follows
the power law. Through the fitting parameters, the DC conductivity was found.

Conclusion :
The results showed that the polymer sample, which was prepared in water
medium and not washed with acetone, had the highest dielectric and conductivity values,
whereas for acetone washed samples highest dielectric and electrical conductivity
was observed for the sample prepared in 2M HCl.
In Silico Insight into the Inhibitory Effects of Active Antidiabetic Compounds from Medicinal Plants Against SARS-CoV-2 Replication and Posttranslational Modification
Authors: Tijjani Habibu , Matinja Adamu Idris , Olatunde Ahmed , Zangoma Maryam Haladu , Mohammed Abubakar , Akram Muhammad , Adeoye Akinwunmi Oluwaseun , Lawal Hamza 
Published: January 2021

Background:The recent reemergence of the coronavirus (COVID-19) caused by the virus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has prompted for the search of effective treatments in forms of drugs and vaccines.Aim:In this regards, we performed an in silico studies of 39 active antidiabetic compounds from medicinal plants to provide insight into their possible inhibitory potentials against SARS-CoV-2 replications and post-translational modifications. Top 12 active antidiabetic compounds with potential for dual inhibition of the replications and post-translational modifications of SARS-CoV-2 were analyzed.Results:Boswellic acids, celastrol, rutin, sanguinarine, silymarin and withanolides expressed binding energy for 3- chymotrypsin-like protease (3CLpro) (-8.0 to -8.9 Kcal/mol), papain-like protease (PLpro) (-9.1 to -10.2 Kcal/mol) and RNA-dependent RNA polymerase (RdRp) (-8.5 to -9.1 Kcal/mol) which were higher than that of the reference drugs (Lopinavir and Remdesivir) used in this study. Sanguinarine, silymarin and withanolides are most drugable phytochemicals among the other following phytochemicals as they obey the Lipinski’s rule of five analyses. Sanguinarine, silymarin and withanolides express moderately soluble with no hepatotoxicity, while silymarin and withanolides cannot permeate the blood-brain barrier and showed no Salmonella typhimurium reverse mutation assay (AMES) toxicity, unlike sanguinarine from the predictive absorption, distribution, metabolism, elimination, and toxicity (ADMET) studies.Conclusion:Sanguinarine, silymarin and withanolides could be proposed for further experimental studies for their development as possible phytotherapy for the COVID-19 pandemic.