bluuebunny/crossref_metadata_2025_split huggingface dataset:
Léiomyome utérin géant accouché par le col : A propos de trois cas à Ouagadougou
Authors: Zongo Nayi , Bagué Abdoul Halim , Windsouri M , Yaméogo P B , Ouédraogo N M L , Sawadogo J 
Published: October 2021

INTRODUCTION : Les léimyofibromes utérins géants accouchés par le col utérin sont rares. MATERIELS ET METHODES : Nous rapportons 3 observations dans le but de décrire notre approche diagnostique et thérapeutique. RESULTATS : Il s’agit de trois patientes âgées de 40, 49 et 41 ans reçues pour des douleurs pelviennes intenses associées à des métrorragies et à une sensation de pesanteur pelvienne. Le délai moyen de consultation était de trois ans. Elles étaient toutes multipares. L’examen gynécologique a permis de noter une masse tissulaire ferme, à surface lisse et régulière de huit cm en moyenne, occupant la cavité vaginale tout en respectant les parois vaginales. L’examen au speculum n’était pas possible à cause la taille de la masse qui affleure le tiers inférieur du vagin. L’imagerie par résonance magnétique a évoqué un myome accouché par le col chez toutes les trois patientes. Une hystérectomie totale a été réalisée chez toutes les patientes. L’histologie de la pièce d’hystérectomie totale a conclu à un léiomyome utérin dans tous les cas. CONCLUSION : Les léiomyomes utérins géants accouchés par le col sont rares. L’imagerie par résonnance magnétique est d’un apport notable dans le diagnostic. Le traitement est le plus souvent une hystérectomie totale chez les femmes non désireuses de grossesse.
Tumeur stromale gastro-intestinale à localisation jéjunale : Une rare cause de masse abdominale chez la femme âgée
Authors: Diallo Adja Coumba , Ndong Abderrahmane , Niang I , Ba Mouhamadou Bachir , Thiam Jaafar Aboutalib , Dieng Pape Souleymane , Ka Sidy , Konate I , Dem Ahmadou 
Published: October 2021

INTRODUCTION : Nous rapportons le cas d’une patiente présentant une masse abdominale dont le diagnostic final est une tumeur stromale gastro-intestinale (GIST). OBSERVATION : Il s’agissait d’une patiente âgée de 61 ans sans antécédents pathologiques, reçue pour une augmentation progressive de volume de l’abdomen évoluant depuis un an, indolore. A l’examen, la patiente avait un bon état général, des constantes normales. Nous notions une masse abdomino-pelvienne d’environ 20 cm de grand axe, mobile. Le reste de l’examen était sans particularité. Le bilan biologique était normal. La tomodensitométrie abdominopelvienne mettait en évidence une masse tissulaire avec des remaniements nécrotiques. Une indication opératoire a été posée. A l’exploration, nous notions une masse développée sur le bord mésentérique à 45 cm de l’angle de Treitz. Elle n’est pas associée à de l’ascite ou à une carcinose péritonéale. Il n’y avait pas de lésion hépatique également. La résection intestinale emportant la masse a été réalisée suivie d’une anastomose termino-terminale. Les suites opératoires étaient simples. L’examen anatomo-pathologique de la pièce opératoire a posé le diagnostic d’une GIST. L’évolution post-opératoire à trois mois était excellente tant sur le plan clinique que radiologique. CONCLUSION : Le cas que nous rapportons souligne la possibilité de retrouver une GIST à localisation jéjunale malgré une présentation clinique peu usuelle. Elle montre également la difficulté d’obtenir un diagnostic préopératoire et le rôle central de la chirurgie dans la prise en charge.
SEBUAH PEMAHAMAN TENTANG SPIRITUALITAS PENDUDUK ASLI BATAK TOBA DAN PENGARUHNYA DALAM KEHIDUPAN SEHARI-HARI
Authors: Donobakti Yohanes Anjar 
Published: October 2021

Spirituality is the dynamic motion of total life driven by the Holy Spirit that flows from the depths of the heart of oneself, lead him/her to the true actions and bring to the meaning ofÂ life. This definition emerged and formed from the experiences oneself in every moment of his/her lives. Spirituality is always associated with every aspect of life in which he/she lives and works, in situations of joy and sorrow, with what and whom he/she interacts and communicates. Came to realize that the reality of the experience of life and the struggle to form a person's quality of life and character make him/her having a deep spirituality. Life will be more meaningful when people are aware and recognize that every event and experience the life through the intervention of God in everything around. We can feel the power of God (the Divine) presents and works in every word and action, in every step of the way of our life. Touched, awared and moved by God, the writer realizes that there is a process and a dynamic relation between human reality and divine reality in an indigenious people spirituality. As we have to know that the indigenious people have a spirituality. They see spirituality as a way of life in which all people are free to be themselves and practice life according to their norms. Therefore, this article is a reflection and understanding of the writer about spirituality of indigenious people, especially Batak Toba tribe in North Sumatera.
Te groot voor de wijkagent, te klein voor de recherche
Authors: Weijers Ido , Ferwerda Henk , Roks Robby 
Published: October 2021

Too big for community policing officers, too small for the detectives. A forgotten group: young rising criminals
We are witnessing a remarkable trend in the youth crime in the Netherlands. A spectacular crime drop is accompanied by growing concerns about the serious nature of youth crimes and young people on a pathway to become hardened criminals at an early age. In this article, we focus on the rise of young offenders in organized drug crime in the Netherlands. We describe some of the features of these young offenders, highlighting their intelligent, strategic and professional behavior. Furthermore, we signal the development and the (territorial) violence of the (youth) groups these young offenders are usually embedded in. In light of these developments, we argue that there is a need for more specialism amongst law enforcement and judicial authorities to identify and deal with these young and potential serious criminals.
Gender Sensitivity Level among Rural Masses
Authors: Duhan Krishna , Rani Nigam , Malik Poonam , Komal . 
Published: October 2021

Women play a fundamental role in the economy of any society. They work as a farmer, on wages basis, as business person, administrator, and entrepreneurs. Women in rural areas face constraints in engaging in all activities viz. cultural, social, economical, health and nutrition etc. Because of gender-based discrimination and social norms, most of their work remains unseen, unrecognized and undervalued. Therefore, this study was conducted on 600 rural (300 male 300 female) people to assess the educational status and sensitivity level. Data was collected with the help of self structured questionnaire by survey method. Results of the study shows that illiterate females (42.90%) were almost double of male (24.40%) that shows high degree of gender disparity in educational level and male members were more sensitized on different aspects (Household responsibility 4.407*, Economical 3.815*, Health and Nutrition 3.243*, Political 2.548*, Media and Technologies 2.126*) as compare to female regarding equality. So, there was a need to promoting gender equality and women’s economic empowerment.
Rapid Detection of Airborne Inocula of Grapevine Mildews Using PCR and LAMP Assay
Authors: Basha J. Shajith , Kamalakannan A. , Saraswathy S. , Johnson I. , Ganapati Patil Santosh , Lakshmi K. R. Swarna 
Published: October 2021

Grapes powdery mildew and downy mildew caused by Erysiphe necator and Plasmopara viticola respectively are the most devastating diseases worldwide resulting in significant loss of yield and quality. Epidemics of grapevine mildews are caused by airborne inocula such as conidia and sporangia. Rapid detection of airborne inocula will help to face up timely management strategies under field conditions. The aim of the current study was to design a suction spore trap to trap the airborne mildew inocula and their early detection by molecular methods of PCR and LAMP assay. A total of twelve airborne inocula samples were collected the weekly intervals from 3 to 14 standard weeks of 2021 during the cropping season. The presence of airborne inocula of E. necator was detected on standard weeks 3,6,10 and 13 through PCR assay which yielded an amplicon of 470 bp. Similarly, airborne inocula of P.viticola were detected on standard week 6 only through PCR which yielded an amplicon of 520 bp. A rapid, highly specific , sensitive Loop mediated isothermal amplification (LAMP) assay was performed to detect the E. necator and P. viticola using six sets of LAMP primers constructed by targeting rDNA region of ITS and the 5S rRNA and CesA4 a gene, respectively. LAMP assay efficiently detected the presence of airborne inocula of E.necator in most of the samples collected from standard week 3 – 14 except 7, 8, and 9. However, the presence of airborne inocula of P.viticola from standard week 3 – 14 was confirmed by LAMP assay. The LAMP assay is absolutely the best in identifying airborne inocula of grapevine mildews compared to PCR and phenotypic microscopic observation.
Calreticulin and JAK2 Exon 12 Mutation Screening in Patients with Myeloproliferative Neoplasms’ in Jeddah Region, Saudi Arabia
Authors: Alkhatabi Heba , Abdulqayoom Heyam , Alserihi Raed , Felimban Raed , Elaimi Aisha , Allala Zinab , Magboli Afaf , Bahashwan Salem , Alsalmi Hashem , Shihah Abdulelah , Abuzenadah Adel , B. Yasin Elrashed 
Published: October 2021

Background: The JAK2 V617F mutation’s discovery has largely facilitated the comprehension of the myeloproliferative neoplasms’(MPNs) pathogenesis. In recent times, calreticulin (CALR) mutations have been detected in patients with JAK2V617F negative primary myelofibrosis (PMF), and essential thrombocythemia (ET).
Methods: This study analyzed the impact of JAK 2 Exon 12 and CALR common mutations in 65 patients with JAK2V617F negative MPN from the Jeddah region. An allele-specific polymerase chain reaction (PCR) method was used to screen four common mutations on Exon 12 and direct sequencing and PCR analysis were utilized to screen all patients for CALR.
Results: None of the patients were positive for the Exon 12 mutation and eight patients were positive for CALR mutations.
Conclusions: This is the first Saudi Arabian research that focused on screening CALR hotspot mutations and this mutation exists. This fact highlights the importance of implementing diagnostic screening of CALR on MPN patients, in general, and patients with high platelet count, in particular. Further screening of other predisposing genetic markers might facilitate the identification of an important genetic variant, which could aid in the understanding of disease pathogenesis.
Methylation Profiling SOCS2 in Philadelphia-Negative Myeloproliferative Neoplasm
Authors: B. Yasin Elrashed 
Published: October 2021

The Janus kinase signal transducer and activator of transcription (JAK / STAT) signalling, which is crucial in Philadelphia-negative myeloproliferative neoplasms’ (MPNs), is negatively regulated by molecules such as SOCS, CISH, and SHP1. SOCS2 methylation has been studied in MPN with conflicting results. Here we examine the methylation status of SOCS2 by specific methylation-specific polymerase chain reaction (MSP) in cell lines and 130 diagnostic prepheral blood samples from Ph-ve MPN. Furthermore, we tried to explain the mismatch of the methylation frequency by assigning the investigated MSP primers to the respective genes. Methylation was detected in normal controls using SOCS2-MSP primers in the 3 'translated exon sequence, but not with primers around the transcription start site in the 5' untranslated regions (5'UTR). SOCS2 was completely unmethylated in primary MPN samples and cell lines. In contrast, SOCS2 methylation when using MSP primers located at the 5'UTR is rare in all studies.
In conclusion, SOCS2 methylation is rare in Ph-ve MPN. The appropriate MSP primers are important for an accurate estimate of the methylation frequency. The role of SOCS2 methylation in MPN pathogenesis requires further investigation.
Modifiable and Non-modifiable Risk Factors Association with Functional Dyspepsia
Authors: Maheshwari Prem Kumar , Liaquat Memon Hassan , Raja Kapeel , Zeb Shaista , Almani Kamran Ahmed 
Published: October 2021

Objective: To determine the frequency of modifiable and non-modifiable risk factors of functional dyspepsia in our population.
Materials and Methods: This cross-sectional study has been conducted department of gastroenterology of Isra University Hospital from February 2019 to January 2020. All the patients of all age groups presented with functional dyspepsia and either of gender were included in the study. Patients were interviewed regarding modifiable and nonmodifiable risk factors like age, gender, smoking, body mass index, alcohol consumption and stress. All the data was gathered via study proforma.
Results: Total 200 cases of functional dyspepsia were studied for modifiable and non-modifiable risk factors. Mean age of the cases was 49.45+6.33 years. Most of the cases were more than 40 years of the age. Males were 64.5% and females were 40.5%. According to the ethnicity Sindhi and Punjabi were commonest as 40.5% and 35.0% respectively. Inadequate physical activity and smoking habits were highly prevalent as 57.5% and 36.0% respectively.
Conclusion: As per study conclusion age more than thirty years, male gender, ethnicity of Sindhi and Punjabi, smoking and inadequate physical activity were observed to be highly prevalent modifiable and non-modifiable risk factor of the functional dyspepsia.
Case Report on Encephalitis
Authors: Dhulse Pallavi Shridhar , Kurian Bibin 
Published: November 2021

Background: Encephalitis is type of brain inflammation caused by a virus, although it can also be caused by a bacterial or fungal infection or an autoimmune reaction. Encephalitis is a viral or inflammatory brain infection causes fever and headache as well as a low level of awareness, altered mental status (confusion, behavior abnormalities) localized neurologic impairments, and new onset seizure activity.
Case Presentation: The case 7 year, old female patient who was alright one month back admitted in “A.V.B.R. Hospital, Wardha, on date 01/12/2020 with the chief complaint of high grade fever, headache, vomiting, irritability, and alteration of speech and generalized weakness. The patient had undergone various investigation complete blood count, urine analysis, kidney function test, liver function test, peripheral smear and virology test. Cerebrospinal fluid, electroencephalogram (EEG) Test, Magnetic resonance imaging (MRI) test, in MRI report shows altered gyral signal intensity is right fronto-parietal lobe with edema with thickened overlying cortex with effacement of adjacent sulcal spaces features suggestive of viral encephalitis. The patient was treated with antipyretic, antibiotic, loop diuretic, steroid, antiemetic drug to treat vomiting. Monitor all vital signs, checked and recorded intake and output, administered medication as prescribed by doctors.
Conclusion: The inflammation of the brain causes encephalitis, which is a rare but deadly disorder. It can be life -threatening and necessitates immediate hospitalization. Anyone can be harmed, but the very young and elderly are the most vulnerable.
Assess the Level of Stress among Parents of Children with Autism at Selected Autism Schools of Vadodara with a View to Give Need Based Education
Authors: Patel Bhavisha , Suresh V. , Patel Bhoomika , Patel Mihir , Patel Monali , Patel Nidhi , Patel Om 
Published: November 2021

Introduction: Children with a Autism spectrum disorders have impairment in the area of communication and social interaction and often display repetitive and non often display. Their parents having stress a to manage their children to education and future purpose. This study has assessed the stress level in parents and manage their stress with coping mechanism.
Aims and Objective: 1) To assess the level of stress among parents of children with autism.2) To find association between level of stress and selected demographic variables.
Methods: The data for main study collection was 30 Parents. Description of the tools refers to the explanation of the content of the tool. The researcher lists the number of items and the scoring for each item in the tool. The tool used for the present study is Parenting stress index - Scale. Descriptive and inferential statistics were applied to analyses the data by using SPSS-20 software. We use purposive sampling technique.
Results: The majority of the parents having a moderate stress (83.3%), and severe stress (10%) and mild stress (6.66%) and nonstress level (0.0%). the stress level analysis showed that stress in parents (R=0.321, p=0.00) at significance of 0.05 level present.
Conclusion: The present study concluded that there is a stress level of parents among children having a moderate stress and there is a no any association between the level of stress and selected demographic variable.
Social Impact of COVID-19 on Rohingya Refugees in Bangladesh and India’s Policy Stand: An Analytical Study
Authors: Puri Nancy , Akhouri C. R. 
Published: November 2021

Aims: The Paper will explore about the COVID- 19 social challenges confronted by the Rohingya refugees in Cox’s Bazar of Bangladesh and will also discuss the role of India in providing medical assistance to Rohingyas in Bangladesh and further will explain a set of policy recommendations designed to improve the life chances of the Rohingya community both now and in the future.
Study Design: Descriptive Study.
Methodology: A detailed and related Review of literature of the previous work has been collected in order to extract the information about the vulnerable conditions of Rohingyas refugees in Bangladesh amid novel coronavirus. The paper is based on qualitative research design and the data has been collected from official reports, documents, newspaper, journal articles, books based on Rohingyas refugees in Bangladesh.
Results: The COVID-19 pandemic represents a grave social threat to the Rohingya refugees in the camps of Bangladesh. Having fled decades of persecution by the Burmese military, the majority of Rohingya currently live in densely populated refugee camps in Bangladesh. Most are denied access to the internet, mobile phones, humanitarian aid, and sanitary conditions and living in congested camps—all of which heighten the risk of infection and contamination. Currently in 2021, Government of India and International Organization are providing COVID- 19 vaccines and medical assistance to Rohingyas in Bangladesh.
Conclusion: Despite facing social impact from COVID- 19, Government of India are taking imperative steps, both to protect the Rohingya from widespread infection and to create the conditions whereby future tragedy can be preempted.
Relationship between drainage capacity and foundation settlement at Pre Rup Temple: Basic study on Khmer architecture drainage systems Part 1
Authors: Kojima Yoko , Mikami Kousei , Shiokawa Hiroyoshi , Shigeeda Yutaka , Agatsuma Hiroki 
Published: October 2021

AbstractIn the ancient city of Angkor, heavy rainfall was common in the rainy season and rapid rainwater drainage was important for maintaining urban functions. This study focuses on the drainage system of an example of Khmer architecture from the Angkor period, the Pre Rup temple built in the year 961. We analyze the relationship between the drainage capacity and foundation settlement, revealing that the foundation settlement was larger near drainage channels with a low drainage capacity. After showing that only a few of the drainage channels function properly, it is possible to have some certainty on the relationship between the drainage capacity and foundation settlement.
Determinants of quality of life in Parkinson’s disease: a perspective of novel clinical subtypes
Authors: Fan Yun , Zhang Mengwei , Liang Xiaoniu , Shen Bo , Xu Zhiheng , Li Shiyu , Hu Tianyu , Wu Bin , Zhao Jue , Sun Yimin , Liu Fengtao , Tang Yilin , Wang Jian 
Published: October 2021

AbstractObjectiveNew subtyping classification systems of Parkinson’s disease (PD) have been proposed for phenotyping patients into three different subtypes: mild motor‐predominant (PD‐MMP), intermediate (PD‐IM) and diffuse malignant (PD‐DM). The quality of life (QoL) underlying the novel PD clinical subtypes is unknown. This study aimed explore the feasibility of the classification in Chinese PD patients and to investigate the potential heterogeneous determinants of QoL among the three subtypes.Methods298 PD patients were enrolled, including 129 PD‐MMP patients, 121 PD‐IM patients and 48 PD‐DM patients. All patients completed the QoL assessment, clinical evaluations and neuropsychological tests. Univariate linear analysis and multiple stepwise regression analysis were performed to identify determinants of QoL.ResultsCompared to PD‐MMP patients, PD‐IM and PD‐DM patients had more impaired QoL. The Geriatric Depression Rating Scale (GDS) score, Non‐Motor Symptoms Questionnaire (NMSQ) score, Unified Parkinson’s Disease Rating Scale part III (UPDRS‐III) score and Epworth Sleepiness Score (ESS) were independent contributors to QoL in PD‐MMP patients. The GDS score, ESS and sniffin’ sticks screening 12 test score were independent contributors to QoL in PD‐IM patients. The GDS score and Mini Mental State Examination score were independent contributors to QoL in PD‐DM patients.InterpretationThe new novel subtyping classification is feasible for Chinese PD patients. Although depression was the most crucial determinant for QoL in PD‐MMP, PD‐IM and PD‐DM patients, the other contributors of QoL in the three subtypes were heterogeneous. These findings may prompt clinicians to target specific factors for improving QoL depending on PD subtypes.
3D‐Printed Synthetic Hydroxyapatite Scaffold With In Silico Optimized Macrostructure Enhances Bone Formation In Vivo
Authors: Van hede Dorien , Liang Bingbing , Anania Sandy , Barzegari Mojtaba , Verlée Bruno , Nolens Grégory , Pirson Justine , Geris Liesbet , Lambert France 
Published: October 2021

Abstract3D printing technologies are a promising approach to treat intra‐oral bone defects, especially those with poor regenerative potential. However, there is a lack of evidence regarding the impact of internal design specifications on the bone regenerative potential. Here, an in silico approach to optimize the internal design of calcium phosphate‐based scaffolds for bone regeneration is proposed. Based on an in silico model of neotissue formation, a gyroid 3D‐printed scaffold is designed and manufactured using UV stereolithography of bioceramic materials. An orthogonal lattice structure 3D‐printed scaffold and a particulate xenograft are used as control groups. The scaffolds are implanted subperiosteally under a shell on rat calvarium for 4 or 8 weeks and bone neoformation performances are investigated by nanofocus computed tomography and decalcified histology. After 8 weeks, the gyroid group is associated with a higher ingrowth potential of the bone and is characterized by signs of osteoinduction (newly formed bone islands). The bone to material contact is similar between the gyroid and the particulate groups. The present results reinforce this in silico modeling strategy to design calcium phosphate‐based 3D scaffolds and the gyroid experimental internal architecture seems to be highly promising for intra‐oral bone regeneration applications.