bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and functional analysis of the C-terminal region of Streptococcus gordonii SspB
Authors: Schormann Norbert , Purushotham Sangeetha , Mieher Joshua L. , Patel Manisha , Wu Hui , Deivanayagam Champion 
Published: August 2021

Streptococcus gordonii is a member of the viridans streptococci and is an early colonizer of the tooth surface. Adherence to the tooth surface is enabled by proteins present on the S. gordonii cell surface, among which SspB belongs to one of the most well studied cell-wall-anchored adhesin families: the antigen I/II (AgI/II) family. The C-terminal region of SspB consists of three tandemly connected individual domains that display the DEv-IgG fold. These C-terminal domains contain a conserved Ca2+-binding site and isopeptide bonds, and they adhere to glycoprotein 340 (Gp340; also known as salivary agglutinin, SAG). Here, the structural and functional characterization of the C123
SspB domain at 2.7 Å resolution is reported. Although the individual C-terminal domains of Streptococcus mutans AgI/II and S. gordonii SspB show a high degree of both sequence and structural homology, superposition of these structures highlights substantial differences in their electrostatic surface plots, and this can be attributed to the relative orientation of the individual domains (C1, C2 and C3) with respect to each other and could reflect their specificity in binding to extracellular matrix molecules. Studies further confirmed that affinity for Gp340 or its scavenger receptor cysteine-rich (SRCR) domains requires two of the three domains of C123
SspB, namely C12 or C23, which is different from AgI/II. Using protein–protein docking studies, models for this observed functional difference between C123
SspB and C123
AgI/II in their binding to SRCR1 are presented.
Managerial innovative capabilities, competitive advantage and performance of healthcare sector during Covid-19 pandemic period
Authors: Vrontis Demetris , El Chaarani Hani , El Abiad Zouhour , El Nemar Sam , Yassine Haddad Alissar 
Published: August 2021

PurposeThe purpose of this paper is to reveal the impact of dynamic managerial innovative capabilities on the competitive advantage (CA), financial performance (FP) and non-financial performance (NFP) of the health-care sector during the very turbulent Covid-19 pandemic period. The focus is on human behavior and personnel interaction in the hospitals that receive Covid-19 cases.Design/methodology/approachData for this research was collected from the medical sector in Lebanon. The authors approached 14 public hospitals and 60 private hospitals for the study and only 48 hospitals (total of 284 respondents) accepted to complete the survey and provide data using a structured questionnaire.FindingsThis study reveals the moderating impact of CA on the relationship between dynamic managerial innovative capabilities and the performance of the health-care sector. Based on 48 Lebanese health-care centers during the Covid-19 pandemic, the results of the structural equation modeling model indicate that dynamic managerial innovative practices positively impact on CA and NFP. The results also reveal that CA has a moderating effect on the relationship between dynamic managerial innovative practices and NFP.Practical implicationsThis study does not reveal any direct or indirect relationship between managerial capabilities and FP during the pandemic.Originality/valueAs the world deals with the Covid-19 pandemic, the health-care sector needs new approaches and methods for confronting the constantly evolving and turbulent environment. This study examines how health-care leaders are dealing with these dynamic challenges and tests a three-dimensional SEM model of dynamic managerial capabilities (sensing, seizing and reconfiguration) that impact CA.
Replicating a study of women and men in state government administration 30 years later
Authors: Mastracci Sharon , Mahallati Nadia 
Published: August 2021

Purpose
The purpose of this study is to examine data from a 2016 replication of a 1986 study of upper-level administrators in government agencies in the US State of Utah. The unique cultural context of this state is used to challenge Hakim’s preference theory; specifically, that the individual agency of work-oriented women is stronger than structural constraints, including culture. This study joins others that have questioned the preference theory’s applicability in certain cultural contexts.

Design/methodology/approach
A simple approach using difference-of-means t-tests shows that female respondents in 2016 are more like their male contemporaries than they are to their sister administrators 30 years prior. T-tests are also used to compare male respondents in 1986 and 2016.

Findings
Women in upper management in 2016 are more likely to be married and have preschool-aged children at home than they were in 1986. These results suggest that women are succeeding at the highest levels in state government administration and also adhering to strong cultural norms. Women’s views on labor market policies changed over time, as well. While women in 2016 are found to resemble their male counterparts in 2016 more than they resemble female respondents in 1986, variations in men’s responses in 1986 and 2016 are statistically no different from zero.

Originality/value
This study challenges the predictions of Hakim’s preference theory in the context of strong cultural norms that dictate separate gender roles. The results contradict the preference theory’s predictions and are consistent with critiques of its applicability across cultural contexts.
Constructing the “good” mother: pride and shame in lone mothers' narratives of motherhood
Authors: Leonard Madeleine , Kelly Grace 
Published: August 2021

PurposeThis paper aims to explore how lone mothers define “good” mothering and outlines the extent to which feelings of pride and shame permeate their narratives.Design/methodology/approachThe empirical data on which the paper is based is drawn from semi-structured interviews with 32 lone mothers from Northern Ireland. All the lone mothers resided in low-income households.FindingsLone mothers experienced shame on three levels: at the level of the individual whereby they internalised feelings of shame; at the level of the collective whereby they internalised how they perceived being shamed by others in their networks but also engaged in shaming and at the level of wider society whereby they recounted how they felt shamed by government agencies and the media.Originality/valueWhile a number of researchers have explored how shame stems from poverty and from “deviant” identities such as lone motherhood, the focus on pride is less developed. The paper responds to this vacuum by exploring how pride may counterbalance shame's destructive and scarring tendencies.
Understanding the social media interactivity paradox: the effects of social media interactivity on communication quality, work interruptions and job performance
Authors: Liu Xiangyu , Zheng Bowen , Liu Hefu 
Published: August 2021

PurposeAlthough social media is widely used for organizational communication, studies have begun to show its controversial effects on job performance in the workplace. To investigate these effects, this study developed a conceptual framework for how social media interactivity affects communication quality and work interruption, as well as how such effects impact job performance.Design/methodology/approachThe proposed theoretical model was empirically validated through a survey study of 556 employees in China.FindingsThe results verified a social media interactivity paradox that indicated social media interactivity increased both communication quality and work interruptions. The results further showed that high levels of social media dependency were a detriment to organizations.Originality/valueThis study verified the existence of a social media interactivity paradox in the use of social media for workplace communication. Moreover, results revealed that the effect of social media interactivity on organizational outcomes depends on its respective dimensions.
Relinquishing power: creating space for youth of color leaders
Authors: Salisbury Jason 
Published: August 2021

PurposeThe purpose of this manuscript is to demonstrate how school and district leaders supported the youth of color leadership initiatives at the district and school levels in ways to advance youth agencies and transformative change. The specific research question guiding this study was What actions do formalized leaders engage in to share leadership opportunities with the youth of color that protect student agencies and control?Design/methodology/approachA multi-site qualitative case study design was used, drawing on the understanding of shared leadership and student voice as analytical lenses.FindingsLeaders across both sites supported the youth of color leadership in three ways: (1) being open to new and different sources of knowledge related to persistent issues of inequity in their schools; (2) initiating spaces for the youth of color to engage in leadership and (3) buffering student leaders from outside pressures.Research limitations/implicationsThis research demonstrates the ways leaders with positional power can support youth of color leadership while not removing youth agencies and independence.Originality/valueThis manuscript contributes to existing scholarship by demonstrating how the understanding of shared leadership and student voice scholarship combines to deepen understanding of supporting youth of color leadership.
Challenges and possible solutions in cross-disciplinary and cross-sectorial research teams within the domain of e-mental health
Authors: Nordgreen Tine , Rabbi Fazle , Torresen Jim , Skar Yngvar Sigmund , Guribye Frode , Inal Yavuz , Flobakk Eivind , Wake Jo Dugstad , Mukhiya Suresh Kumar , Aminifar Amin , Myklebost Sunniva , Lundervold Astri J. , Kenter Robin , Hammar Åsa , Nordby Emilie , Kahlon Smiti , Tveit Sekse Ragnhild J. , Griffin Kristine Fonnes , Jakobsen Petter , Pham Minh H. , Côté-Allard Ulysse , Noori Farzan Majeed , Lamo Yngve 
Published: August 2021

PurposeMental illness presents a huge individual, societal and economic challenges, currently accounting for 20% of the worldwide burden of disease. There is a gap between the need for and access to services. Digital technology has been proven effective in e-mental health for preventing and treating mental health problems. However, there is a need for cross-disciplinary efforts to increase the impact of e-mental health services. This paper aims to report key challenges and possible solutions for cross-disciplinary and cross-sectorial research teams within the domain of e-mental health.Design/methodology/approachThe key challenges and possible solutions will be discussed in light of the literature on effective cross-disciplinary research teams.FindingsSix topics have been key challenges in our cross-disciplinary and cross-sectorial research team: to develop a shared understanding of the domain; to establish a common understanding of key concepts among the project participants; to involve the end-users in the research and development process; to collaborate across sectors; to ensure privacy and security of health data; and to obtain the right timing of activities according to project dependencies.Research limitations/implicationsThis study focuses to increase knowledge and training in cross-disciplinary and cross-sectorial research, as this is often referred to as an important tool when developing sustainable solutions for major societal challenges.Practical implicationsThis study needs to include theory and skills training in cross-disciplinary research in research training.Social implicationsCross-disciplinary teams have the potential to address major societal challenges, including more perspectives and more stakeholders than single disciplinary research teams.Originality/valueMajor societal challenges require complex and sustainable solutions. However, there is a lack of knowledge about how cross-disciplinary and cross-sectorial research teams may work productively to solve these challenges. This paper shares experiences regarding the challenges and possible solutions for productive collaboration in cross-disciplinary and cross-sectorial research teams within the domain of e-mental health services.
Linking emotional intelligence to turnover intention: LMX and affective organizational commitment as serial mediators
Authors: Gara Bach Ouerdian Emna , Mansour Nizar , Gaha Khadija , Gattoussi Manel 
Published: August 2021

PurposeThe present study attempts to examine the mediating effect of leader member exchange (LMX) and affective organizational commitment on the relationship between followers' emotional intelligence (EI) and their turnover intention.Design/methodology/approachUsing a cross-sectional design, survey data were obtained from 182 employees in Tunisia. Survey responses were analyzed using Model 6 in PROCESS (Hayes, 2017).FindingsAs predicted, LMX and affective organizational commitment were found to sequentially and totally mediate the causal relationship between EI and turnover intention.Research limitations/implicationsThe limitations include using a cross-sectional design, convenience sampling and self-report measures for EI, LMX, affective commitment and turnover intention.Practical implicationsOrganizations need to encourage more emotionally intelligent responses in employees which improve the quality of their leader–follower relationships. The quality of LMXs enhances the affective commitment that drives lower turnover intention.Originality/valueWhile the relationship between EI and turnover intention has been theorized, this study is one of the first to enable us to explore the mechanisms underlying this relationship. Specifically, a sequential mediation model linking EI with turnover intention through LMX and affective commitment was proposed.
Preventing unnecessary referrals into specialist mental health services: an interrupted time-series evaluation of a new primary care-linked mental health service
Authors: Healey Andrew , Melaugh Alexandra , Demetriou Len , Power Tracey , Sevdalis Nick , Pritchard Megan , Goulding Lucy 
Published: August 2021

Purpose
Many patients referred by their GP for an assessment by secondary mental health services are unlikely to ever meet eligibility thresholds for specialist treatment and support. A new service was developed to support people in primary care. “the authors evaluate” whether the phased introduction of the Lambeth Living Well Network (LWN) Hub to a population in south London led to: a reduction in the overall volume of patients referred from primary care for a secondary mental health care assessment; and an increase in the proportion of patients referred who met specialist service eligibility criteria, as indicated by the likelihood of being accepted in secondary care.

Design/methodology/approach
The evaluation applied a quasi-experimental interrupted time series design using electronic patient records data for a National Health Service (NHS) provider of secondary mental health services in south London.

Findings
Scale-up of the Hub to the whole of the population of Lambeth led to an average of 98 fewer secondary care assessments per month (95% CI −118 to −78) compared to an average of 203 assessments per month estimated in the absence of the Hub; and an absolute incremental increase in the probability of acceptance for specialist intervention of 0.20 (95% CI; 0.14 to 0.27) above an average probability of acceptance of 0.57 in the absence of the Hub.

Research limitations/implications
Mental health outcomes for people using the service and system wide-service impacts were not evaluated preventing a more holistic evaluation of the effectiveness and cost-effectiveness of the LWN Hub.

Practical implications
Providing general practitioners with access to service infrastructure designed to help people whose needs cannot be managed within specialist mental health services can prevent unnecessary referrals into secondary care assessment teams.

Social implications
Reducing unnecessary referrals through provision of a primary-care linked mental health service will reduce delay in access to professional support that can address specific mental-health related needs that could not be offered within the secondary care services and could prevent the escalation of problems.

Originality/value
The authors use NHS data to facilitate the novel application of a quasi-experimental methodology to deliver new evidence on whether an innovative primary care linked mental health service was effective in delivering on one of its key aims.
Design, simulation, testing and application of laser-sintered conformal lattice structures on component level
Authors: Marschall David , Sindinger Sigfrid-Laurin , Rippl Herbert , Bartosova Maria , Schagerl Martin 
Published: August 2021

Purpose
Laser sintering of polyamide lattice-based lightweight fairing components for subsequent racetrack testing requires a high quality and a reliable design. Hence, the purpose of this study was to develop a design methodology for such additively manufactured prototypes, considering efficient generation and structural simulation of boundary conformal non-periodic lattices, optimization of production parameters as well as experimental validation.

Design/methodology/approach
Multi-curved, sandwich structure-based demonstrators were designed, simulated and experimentally tested with boundary conformal lattice cells. The demonstrator’s non-periodic lattice cells were simplified by forward homogenization processes. To represent the stiffness of the top and bottom face sheet, constant isotropic and mapped transversely isotropic simulation approaches were compared. The dimensional accuracy of lattice cells and demonstrators were measured with a gauge caliper and a three-dimensional scanning system. The optimized process parameters for lattice structures were transferred onto a large volume laser sintering system. The stiffness of each finite element analysis was verified by an experimental test setup including a digital image correlation system.

Findings
The stiffness prediction of the mapped was superior to the constant approach and underestimated the test results with −6.5%. Using a full scale fairing the applicability of the development process was successfully demonstrated.

Originality/value
The design approach elaborated in this research covers aspects from efficient geometry generation over structural simulation to experimental testing of produced parts. This methodology is not only relevant in the context of motor sports but is transferrable for all additively manufactured large scale components featuring a complex lattice sub-structure and is, therefore, relevant across industries.
In the COVID era, business leaders must put inclusivity above expediency
Authors: Trehan Rita 
Published: August 2021

Purpose
This paper aims to identify the management practices and priorities best suited to present-day workforce needs.

Design/methodology/approach
From 19 March to 6 April 2021, Dare Worldwide conducted linear regression analysis aimed at understanding the key drivers of employee performance. The target population surveyed was: US adults who are employees of companies with at least 500 employees with a job title of manager or higher within selected industries (manufacturing, information, financial services, professional and business services, leisure and hospitality, wholesale and retail, education, health and government).

Findings
The research showed 85% of performance indicators is not linked to company performance and that employees value trust, engagement and communication. Businesses favour rapid adaptation to cope with crises and technology to drive job performance. In the survey, the highest performing factors for business were related to old-fashioned notions of expediency, none of which will impact company performance over the next five years. Employees meanwhile valued inclusivity and collaboration over expediency.

Originality/value
The research showed that c-suits are focussing on the wrong managerial processes and priorities to be successful over the long term. Helping employees understand and shape the purpose of their company will be critical as employees evaluate their motivations post COVID. The Dare Worldwide 2021 findings have implications for how senior management teams relate to their staff in an era of remote working and changing employee values and priorities.
Identification of novel compound heterozygous ITGB4 mutations in a Chinese woman with junctional epidermolysis bullosa without pylori atresia but profound urinary symptoms: A case report and review of the literature
Authors: Zhou Xingli , Wang Mi , Wang Sheng , Jiang Xian , Li Wei 
Published: August 2021

AbstractLoss of α6 and β4 integrin expression caused by germ line mutations in ITGA6 and ITGB4 usually leads to junctional epidermolysis bullosa (JEB) with pyloric atresia (PA) (JEB‐PA; Online Mendelian Inheritance in Man #226730). However, recent studies have suggested that integrin‐associated JEB may occur without PA but with other symptoms of the epithelial tissues. Here, we present a case of a Chinese woman with JEB without PA but with profound urinary symptoms. Mutation analysis revealed that the patient carried compound heterozygous mutations in the ITGB4 gene: a frameshift mutation c.600dupC (p.Phe201Leufs*15) and a novel missense mutation c.599C>G (p.Pro200Arg). Our report not only raises the question of whether the designation JEB‐PA is appropriate, but also expands our current knowledge of the ITGB4 mutation spectrum.
Forest fragmentation drives liana community structure but not the patterns of liana–tree interaction network in two forest ecosystems in Ghana
Authors: Addo‐Fordjour Patrick , Marfo Isaac , Ofosu‐Bamfo Bismark 
Published: August 2021

AbstractWe assessed fragmentation impact on liana community structure and patterns of liana–tree interaction network structure, and edge effects on liana community structure in a rainforest and a moist semi‐deciduous (MSD) forest in Ghana. In each forest, we randomly established 30 20 × 20 m2 plots at varied distances (0–20 m, 20–40 m, 40–60 m, 60–80 m, 80–100 m) from forest edge to interior in fragmented and intact sites. Lianas with diameter at 1.30 m from rooting base ≥1 cm and their host trees (diameter at breast height ≥ 5 cm) were identified and counted. Our findings revealed that fragmentation caused an increase in liana diversity in the rainforest, but not in the MSD. Fragmentation also resulted in shifts in species composition in both forests, and together with edge effects increased liana abundance in both forest ecosystems. Liana–tree networks in the two forest ecosystems were less nested and connected, but more modular and specialized than their corresponding null models irrespective of fragmentation. Some species of lianas (rainforest fragment/intact: 0.80/0.76%; MSD fragment/intact: 0.47/0.38%) and trees (rainforest fragment/intact: 0.65/0.35%; MSD fragment/intact: 0.54/0.36%) exhibited higher specialization than their null models. Topologically, most lianas in fragmented and intact sites of the forests played peripheral/specialist roles, whereas a few species exhibited structural importance in the form of connectors, network hubs and module hubs. The structural important species in fragmented sites did not also occur in intact sites, suggesting that fragmentation might have influenced topological roles of the species in fragmented sites.