bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation
Authors: Cartwright Ian M. , Dowdell Alexander S. , Lanis Jordi M. , Brink Kathryn R. , Mu Andrew , Kostelecky Rachael E. , Schaefer Rachel E. M. , Welch Nichole , Onyiah Joseph C. , Hall Caroline H. T. , Gerich Mark E. , Tabor Jeffrey J. , Colgan Sean P. 
Published: May 2021

SignificanceTissue acidification is commonly associated with active inflammation, including within the intestinal mucosa. It remains unclear how such acidification impacts cellular function and adaptation to these changes within the tissue. In the present work, we utilized unbiased gene expression profiling to identify pathways elicited by extracellular acidification. Results from these studies identify a prominent role for cyclic AMP response element-binding protein signaling in the molding of gene expression in intestinal epithelia. This acidification-induced phenotype is translatable from in vitro cell culture systems to in vivo murine models and through to patients with active intestinal inflammation.
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis
Authors: Watanabe Satoshi , Markov Nikolay S. , Lu Ziyan , Piseaux Aillon Raul , Soberanes Saul , Runyan Constance E. , Ren Ziyou , Grant Rogan A. , Maciel Mariana , Abdala-Valencia Hiam , Politanska Yuliya , Nam Kiwon , Sichizya Lango , Kihshen Hermon G. , Joshi Nikita , McQuattie-Pimentel Alexandra C. , Gruner Katherine A. , Jain Manu , Sznajder Jacob I. , Morimoto Richard I. , Reyfman Paul A. , Gottardi Cara J. , Budinger G. R. Scott , Misharin Alexander V. 
Published: May 2021

SignificanceDisordered epithelial proteostasis is strongly implicated in the pathobiology of pulmonary fibrosis. We found that a small molecule that specifically restores protein translation by EIF2B during activation of the integrated stress response, ISRIB, attenuated the severity of pulmonary fibrosis in young adult and old mice. Our data support a multicellular model of fibrosis in which relieving a block to epithelial differentiation induced by activation of the integrated stress response slows the recruitment of profibrotic monocyte-derived alveolar macrophages to attenuate pulmonary fibrosis. A loss of proteostasis resilience in aging would further slow repair, perhaps explaining the increased risk of fibrosis in the elderly.
Just 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in communities
Authors: Yang Qing , Saldi Tassa K. , Gonzales Patrick K. , Lasda Erika , Decker Carolyn J. , Tat Kimngan L. , Fink Morgan R. , Hager Cole R. , Davis Jack C. , Ozeroff Christopher D. , Muhlrad Denise , Clark Stephen K. , Fattor Will T. , Meyerson Nicholas R. , Paige Camille L. , Gilchrist Alison R. , Barbachano-Guerrero Arturo , Worden-Sapper Emma R. , Wu Sharon S. , Brisson Gloria R. , McQueen Matthew B. , Dowell Robin D. , Leinwand Leslie , Parker Roy , Sawyer Sara L. 
Published: May 2021

Significance
We analyzed data from saliva-based COVID-19 screening deployed on the University of Colorado Boulder campus. Our dataset is unique in that all SARS-CoV-2−positive individuals reported no symptoms at the time of saliva collection, and therefore were infected but asymptomatic or presymptomatic. We found that 1) the distribution of viral loads observed in our asymptomatic college population was indistinguishable from what has been reported in hospitalized populations; 2) regardless of symptomatic status, approximately 50% of individuals who test positive for SARS-CoV-2 seem to be in noninfectious phases of the infection; and 3) just 2% of infected individuals carry 90% of the virions circulating within communities, serving as viral “supercarriers” and likely also superspreaders.
Absence of long-range magnetic order in lithium-containing honeycombs in the Li–Cr–Sb(Te)–O phases
Authors: Mandujano H Cein , Gonzalez Sandra L , Episcopo Nathan , Sitharaman Uma , Poudel Narayan , Gofryk Krzysztof , Garay Yahir E , Lopez Jorge A , Zhang Qiang , Calder Stuart , Nair Harikrishnan S 
Published: May 2021

Abstract
Li3((LiCr)(Te/Sb))O6 compounds where Cr atoms along with Li and Te or Sb are part of a honeycomb and are studied using magnetic susceptibility, specific heat, x-ray photoelectron spectroscopy and neutron diffraction. The oxides stoichiometries as determined from the neutron diffraction studies are Li4.47Cr0.53TeO6 and Li3.88Cr1.12SbO6 with a stable oxidation state of +3 for Cr. Both the compounds crystallize in space group C2/m with intermixing of cations at the 4g sites leaving the 2a sites preferentially for Te or Sb. Again, the Li+ ions alone predominantly occur in the interlayer sites. Both the compounds show a broad anomaly in specific heat at 8 K, which is robust against 8 T. A corresponding anomaly is absent in the magnetic susceptibility but recovers from its derivative, dχ(T)/dT. We ascertain the magnetic anomaly temperatures (T

a
) of Li4.47Cr0.53TeO6 and Li3.88Cr1.12SbO6 as 5.9 K and 6.7 K respectively from specific heat. Although the physical properties indicated a low temperature anomaly, neutron diffraction data did not reveal a magnetic signal or a structural anomaly down to 1.5 K. This rules out a conventional long-range ordered magnetic ground state in either compounds. Combining the results from specific heat, neutron diffraction and electron paramagnetic resonance, we put forth a scenario of depleted honeycomb lattice of Cr3+ with predominant short-range magnetic correlations as the magnetic ground states of the title compounds.
Effect of transport current on suppression of superconductivity with ultrashort laser pulse
Authors: Kartsev P F , Kuznetsov I O 
Published: May 2021

Abstract
We study the suppression of superconductivity with ultrashort laser pulse in the presence of transport current. The theoretical model is based on the Bardeen–Cooper–Schrieffer relations for the superconducting state coupled with kinetic equations for nonequilibrium Bogoliubov quasiparticles and phonons. The results of numerical simulation for picosecond and femtosecond laser pulses of optical and infrared ranges are given. We discuss the effects of main problem parameters, including the current density.
Multi-layer graphene pirani pressure sensors
Authors: Romijn Joost , Dolleman Robin J , Singh Manvika , van der Zant Herre S J , Steeneken Peter G , Sarro Pasqualina M , Vollebregt Sten 
Published: May 2021

Abstract
The operating principle of Pirani pressure sensors is based on the pressure dependence of a suspended strip’s electrical conductivity, caused by the thermal conductance of the surrounding gas which changes the Joule heating of the strip. To realize such sensors, not only materials with high temperature dependent electrical conductivity are required, but also minimization of the suspended strip dimensions is essential to maximize the responsivity and minimize the power consumption. Due to this, nanomaterials are especially attractive for this application. Here, we demonstrate the use of a multi-layer suspended graphene strip as a Pirani pressure sensor and compare its behavior with existing models. A clear pressure dependence of the strip’s electrical resistance is observed, with a maximum relative change of 2.75% between 1 and 1000 mbar and a power consumption of 8.5 mW. The use of graphene enables miniaturization of the device footprint by 100 times compared to state-of-the-art. Moreover, miniaturization allows for lower power consumption and/or higher responsivity and the sensor’s nanogap enables operation near atmospheric pressure that can be used in applications such as barometers for altitude measurement. Furthermore, we demonstrate that the sensor response depends on the type of gas molecules, which opens up the way to selective gas sensing applications. Finally, the graphene synthesis technology is compatible with wafer-scale fabrication, potentially enabling future chip-level integration with readout electronics.
Activation energies during glass transition and fragility of the As30Te64Ga6 chalcogenide glass
Authors: Hassan R M , Neffati R , Abd-Elnaiem A M , Dahshan A 
Published: May 2021

Abstract
Glass transition features of chalcogenides are important for the broad and increasing industrial applications of these glassy semiconductors. Hence, differential scanning calorimetry was applied at different scanning rates on As30Te64Ga6 prepared by conventional melt quenching technique in order to study their glass transition and fragility. The Kauzmann temperature was estimated to about 136 K while its glass transition is about 397 K at 10 K min−1. Different experimental evaluation methods gave the same fragility index m = 25 or D = 71 which is typical of a strong liquid corresponding to the prepared glass. Four iso-conversional methods were then applied to monitor the change in the activation energy for the temperature range corresponding to the transition from glass to liquid. All methods give a small monotonic decrease of the activation energy during transition from 108 to 99 kJ mol−1 confirming the strong character.
Foraging Ecology of Birds in Mudflat Area of Tanjung Laboh, Johor
Authors: Fauzi N A , Norazlimi N A 
Published: May 2021

Abstract
Tanjung Laboh is located in one out of three Important Bird Areas (IBAs) in Johor called South West Johor Coast which is very crucial foraging ground for resident and migratory shorebirds. However, the airfield development plan located in the area have been an issue as it might disturbed the foraging ecology of the shorebirds. Therefore, it is necessary to analyse the food resources present and the foraging behaviour of the shorebirds in order to determine the effect of disturbance towards the shorebirds’ foraging behaviour. Thus, a study was conducted for a month (July to August 2018) in the mudflat area of Tanjung Laboh to identified the time spent of foraging, food selection and foraging technique of shorebirds by using direct observation method. A total of 212 observations were recorded during sampling period. No significant differences were found in time spent foraging between the bird species, (F = 0.18, p = 0.946). A Spearman Rank Correlation proved that there is no significant relationship between the time spent of foraging and the number of preys taken by each species (R = 0.436, p > 0.05). Based on observation, fish is the most preferred diet choice among bird species which counts a total of 57% followed by unknown (20%), worm (19%) and bivalve (4%). Significant correlation was found between the abundance of bird and the frequency of disturbances (humans, dogs and vehicles) (p < 0.05) while human contribute to a higher percentage in disruptions towards the species studied (57.7%). The responses of the birds towards the disturbances were varied in this study, however the birds tend to choose foraging ground far from disturbance area as the disturbances might chase birds’ prey away thus reduce their feeding rate. By understanding how the shorebirds response toward disturbance, the conservation action can be enforced in the future.
Antioxidant Activities in Different Parts of Pulasan (Nephelium mutabile Blume) from East Borneo
Authors: Hairunisa I , Mentari I A , Julianti T , Wikantyasning E R , Cholisoh Z , Ningsih S C , Muslim M R F 
Published: May 2021

AbstractNephelium mutabileBlume (Traditionally known as Pulasan or Kapulasan) is a plant resembling the rambutan fruit that grows mostly on the islands of Sumatra and Kalimantan. Pulasan has a unique characteristic, the skin of this fruit was hairless and had very bright color. The aim of this study was to determine the antioxidant activity of different parts of the Pulasan, including the peels, seeds and leaves. Antioxidant activity was determined by IC50values using the DPPH method (2,2-diphenyl-1-picrylhydrazyl) with Vitamin C as a positive control. Each part of the plant was extracted using 96% ethanol then the total phenolic compound was tested using a gallic acid as the standard. The results showed that ethanol extract of pulasan leaves had the highest antioxidant activity with the value 20.99 µg/mL (very strong antioxidant), while the seeds and peels of pulasan showed antioxidant activity of 520.68 µg/mL and >1000 µg/mL (not active as antioxidants) respectively. This result shows that ethanol extract from the leaves of Pulasan has potential to be developed as a source of natural antioxidants.
The development of risk management elements (APR) for Forest-Friendly Pedagogy (PERIMBA) as a guide for indigenous school teacher
Authors: Haron M N , Wahab N B A , Kasim R , Abdullah N , Bohari N M 
Published: May 2021

Abstract
The Forest-friendly pedagogy (PERIMBA) refers to the implementation of outdoor learning session by using forest elements as the learning aid and site. In promoting meaningful learning especially to the indigenous school, PERIMBA’s introduces a risk-taking approach that will offer the opportunities for teachers and pupils to engage in risky activities during learning session. The input on risk and risk perception will be an added value to teachers to implement PERIMBA in their teaching and learning sessions. However, PERIMBA’s needs further research and study especially in the field of risk. These concepts then lead to risk perception that, in turn, influenced risk management. The purpose of this study is to identify risk management element for forest-friendly pedagogy (PERIMBA) at Indigenous School. To achieve this goal, this study is conducted qualitative in the form of analysis document. A few of previous document, survey report, conference proceeding, and journal had been referred as literature study, and analysed with data gathered use schedule matric. The finding shows that there are three elements which are risk identification, risk assessment and risk control.
Mitochondrial Barcodes of Dragonflies and Damselflies Originated from Taman Negara Endau Rompin, Johor, Malaysia
Authors: Lam Y T , Kamarudin K R , Zakaria M Z , Omar M S S , Tokiman L , Jahari P N S , Mohd Salleh F 
Published: May 2021

Abstract
Dragonflies and damselflies (Odonates) are important biological indicators in freshwater ecosystems. However, identification among Odonates is often challenging due to their similar morphological features. Therefore, the incorporation of morphological identification by taxonomists and validation using mitochondrial barcodes such as cytochrome c oxidase subunit I (COI) can be a more reliable approach to enhance the accuracy in species identification. In this study, four COI barcodes for Malaysian dragonflies (Neurothemis fluctuans) and damselflies (Neurobasis chinensis, Aristocypha fenestrella and Sundacypha petiolata) were generated. Three of the generated barcodes (D2 COI, D4 COI and D5 COI) supported the species identified by taxonomists meanwhile D3 COI deduced that the damselfly species was misidentified due to the very similar morphology between the same genus of damselfly. All of the COI barcodes are now available in the GenBank with the accession numbers of MT266926.1 (D2 COI), MT266925.1 (D3 COI), MT269676.1 (D4 COI) and MT266924.1 (D5 COI).
Effect of different banana pseudostem parts on their starch yield, morphology and thermal properties
Authors: Mohd Ali N A , Abdullah N , Jong S H , Muhammad N , Tan M C 
Published: May 2021

AbstractSince banana tree cannot produce fruit twice, there is an abundance of pseudostem left as abandoned crop waste and this leads to environmental pollution. This research was conducted to evaluate the effect of different parts of banana pseudostem on the yield, morphology and thermal properties of the starch. The pseudostem was divided into three parts, which are the outer part of pseudostem (OPS), inner part of pseudostem (IPS) and the whole part of pseudostem (WPS). The starch yield from different parts was evaluated. The morphological and thermal properties of each starch were determined by scanning electron microscopy and thermoanalytical technique, respectively. The result shows that yield of starch obtained were 0.08 % higher in OPS compared to IPS. The yield of starch obtained range from 0.12-0.20 %. The iodine test had confirmed the presence of starch obtain from the pseudostem. All the starch showed irregular and spherical shape based on morphology observation. The gelatinization temperature of starch was between 71.15°C-76.50°C. The gelatinization temperature of starch obtained from IPS is 3.6 % higher compared to OPS and WPS. The results from this finding show that the starch obtained from pseudostem could be a potential source of starch that can be commercialized, and thus increase the sources of starch in the food industry.
Evaluating physiological responses of Butterfly pea, Clitoria ternatea L. var. Pleniflora to salt stress
Authors: Mohd Nasim N A , Pa’ee F 
Published: May 2021

Abstract
Nowadays, proportions of agriculture land had become saline. Many plants and herbs have evolved series of defences to mitigate against salinity. There were critical appraisal studies on salinity using the butterfly pea, Clitoria ternatea var Pleniflora that analysed their potential role as salt tolerant legume. However, study on the physiological responses of Clitoria ternatea is still lacking. Therefore, the purpose of this study was to introduce and evaluate the growth traits of Clitoria ternatea var Plenifora with regards to the number of branches and leaves, plant’s height, fresh and dry weight of plant parts (stem, leaves and roots) during the exposure to six different doses of NaCl (0, 100, 150, 200, 250 and 300 mM). In addition, controlled growth environment was watered daily with equal NaCl-supplemented distilled water. The results from this study had revealed that all of the test growth traits: the number of branches and leaves, height of plants, fresh weight of leaves and dry weight of stem, leaves and roots were the highest under 200 mM of NaCl. In conclusion, 200 mM of NaCl can improve the overall growth of Clitoria ternatea var Pleniflora.
Development of Etlingera elatior pearl for drinks and cocktail
Authors: Muhamad A N , Kormin F , Zainol-Abidin N A , Mohamed-Anuar N A F , Zainol-Abidin N A 
Published: May 2021

Abstract
Herbs such as Etlingera elatior (torch ginger flower) is well known in Malaysia and one of the main sources of phytochemicals with strong antioxidant activity. A recent study is done to develop herbs into new confectionery products, pearls in drinks and cocktails. In this research, the screening process is done to select the best pearl formulation, which described the desired viscosity and pH. The mixture variables are different types of starch (xanthan gum, modified cassava flour, hanjeli flour, and modified suweg flour). Five out of 20 pearl formulations are chosen for texture profile, antioxidant analysis, and sensory analysis. The result shows pearl formulation 2 (467.62 g force) has the highest hardness of the pearl, while the stickiest is pearl formulation 4 (-9.24 g force). The pearl formulation 2 has the highest antioxidant capacity when tested with TPC (6.61 μgGAE/ml), TFC (177.42 μgRE/ml) and ABTS (56.74 %). Contradict to this result, the highest DPPH antioxidant properties are pearl formulation 1 (69.98 %). The sensory analysis by 9-point hedonic scale result shows that the average mean of overall acceptance is formulation 2.
Dinomyrmex gigas (Latreille, 1802): A Potential Icon for Taman Negara Johor Endau Rompin
Authors: Muhammad Shafiq H , Maryati M 
Published: May 2021

Abstract

Dinomyrmex gigas (Latreille, 1802) is one of the largest ants in the world and the largest in Southeast Asia. It is also more commonly known as the giant forest ant. This large charismatic ant can be found in the forests of Southeast Asia, however it is not often sighted by the public due to its predominant nocturnal nature. Despite being considerably well studied compared to its smaller counterparts, most people know little about the giant forest ant beyond its large size. Most studies on this species focus on the populations found in Malaysia and Brunei characterizing many aspects of the natural history and biology of this species including its foraging behaviour, diet, territoriality, reproduction and colony structure. While much is known about the biology of this species, fragmented forest habitats may have an impact on the viability and behaviour of this majestic giant ant of the forest. This study involved insects’ viability observation and sampling of ant specimens. The results of observations showed that D. gigas is viable in Endau Rompin Johor National Park (TNJER). Then, various ecological aspects of D. gigas was investigated through field studies and secondary information. Due to its size and uniqueness this species has a potential to be developed into a nature tourism product for Malaysia. The present study elaborated to further discover its daily activity, nesting and defence behaviour which could be useful in developing it into a nature tourism product. As the species is also limited in distribution to undisturbed forest, the issue of its survival is discussed with relation to conservation of the tropical rainforest.
Exploring Tourists’ Knowledge, Perceptions and Willingness to Pay on Biodiversity Conservation: Insights from Kinabalu Park, Borneo
Authors: Musa F , Ahmad Nasir N S , Jaunis O , Mohd Hamdan D D 
Published: May 2021

Abstract
The richness of biodiversity and ecotourism development in Malaysia has contributed to economic growth and human well-being. In this context, Kinabalu Park, Borneo, offers the uniqueness of biodiversity as the main attraction to local and foreign tourists. However, the economic value of biodiversity is difficult to quantify due to the non-existent market for these resources. This study explored the tourists’ knowledge and perception regarding the biodiversity issues and estimated the Willingness to Pay (WTP) for Kinabalu Park’s biodiversity conservation using the Contingent Valuation Method (CVM). A total of 250 questionnaires with five bid prices were distributed to local (RM3, RM6, RM9, RM12, and RM15) and international tourists (RM15, RM30, RM45, RM60, and RM75). This study reported that more than half of the respondents are willing to pay for the conservation of biodiversity. Most local and international tourists are willing to pay RM5 and RM84.05 per person, respectively. The Principle Component Analysis (PCA) in Factor Analysis showed that the “environmental” factor had the highest eigenvalue compared to the “social” factor. This finding shows that tourism has a very significant environmental attitude and preferences towards the conservation of biodiversity. The financial planning management can help the stakeholders in biodiversity conservation programs at Kinabalu Park for better governance in the future.
Potential Dopant in Photocatalysis Process for Wastewater Treatment-A Review
Authors: Razali N A , Othman S A 
Published: May 2021

Abstract
Nowadays, too much pollution has happened around us, and one of them is water pollution, which each day has become more severe and worse. One of the sources of water pollution comes from the industry that has used dyes either excessively or not. In case of that, the wastewater needs to be treated before released to the river or environment. In this paper, a review of the wastewater treatment using dopants such as nitrogen and magnesium, will be discussed.