bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data Preprocessing as a Service – Outsourcing der Datenvorverarbeitung für KI-Modelle mithilfe einer digitalen Plattform
Authors: Kureljusic Marko , Karger Erik 
Published: October 2021

ZusammenfassungSowohl in der Praxis als auch in der Wissenschaft kam es in den vergangenen Jahren zu einem zunehmenden Interesse an datenintensiven Verfahren, wie der künstlichen Intelligenz. Die Mehrheit dieser Data-Science-Projekte fokussierte sich auf den Erklärungsgehalt und die Robustheit der Modelle. Vernachlässigt wurde hierbei häufig der Prozess der Datenvorverarbeitung, obwohl dieser ca. 80 % der Zeit eines Data-Science-Projekts beansprucht. Im Rahmen der Datenvorverarbeitung, welche auch als Data Preprocessing bezeichnet wird, werden Daten akquiriert, bereinigt, transformiert und reduziert. Das Ziel dieser Vorgehensweise ist die Generierung eines Datensatzes, welcher sich für Trainings- und Testzwecke der Data-Science-Modelle eignet. Somit ist das Data Preprocessing ein erforderlicher Prozessschritt, der für das maschinelle Erlernen von korrekten Mustern und Zusammenhängen notwendig ist. Häufig scheitern Data-Science-Projekte jedoch an der mangelhaften Datenvorverarbeitung. So werden beispielsweise fehlerhafte Daten nicht vorab identifiziert, wodurch möglicherweise falsche Zusammenhänge erlernt werden. Dies führt dazu, dass der Erklärungsgehalt der Data-Science-Modelle signifikant verringert wird. Eine Möglichkeit, dieses Problem zu lösen, ist das Outsourcing der Datenvorverarbeitung an spezialisierte Fachkräfte. Mithilfe einer Plattform kann ein sicherer und automatisierter Datenaustausch zwischen Kunden und Dienstleistern gewährleistet werden. Der vorliegende Beitrag thematisiert, wie die Plattform für das Data Preprocessing genutzt werden kann, um eine effizientere und schnellere Bereitstellung der Daten zu ermöglichen.
Electrophysiology and the magnetic sense: a guide to best practice
Authors: Fenton Georgina E. , Nath Kamalika , Malkemper E. Pascal 
Published: October 2021

AbstractMagnetoreception, sensing the Earth’s magnetic field, is used by many species in orientation and navigation. While this is established on the behavioural level, there is a severe lack in knowledge on the underlying neuronal mechanisms of this sense. A powerful technique to study the neuronal processing of magnetic cues is electrophysiology but, thus far, few studies have adopted this technique. Why is this the case? A fundamental problem is the introduction of electromagnetic noise (induction) caused by the magnetic stimuli, within electrophysiological recordings which, if too large, prevents feasible separation of neuronal signals from the induction artefacts. Here, we address the concerns surrounding the use of electromagnetic coils within electrophysiology experiments and assess whether these would prevent viable electrophysiological recordings within a generated magnetic field. We present calculations of the induced voltages in typical experimental situations and compare them against the neuronal signals measured with different electrophysiological techniques. Finally, we provide guidelines that should help limit and account for possible induction artefacts. In conclusion, if great care is taken, viable electrophysiological recordings from magnetoreceptive cells are achievable and promise to provide new insights on the neuronal basis of the magnetic sense.
Efficacy and safety of immune checkpoint inhibitors in colorectal cancer: a systematic review and meta-analysis
Authors: Zeng Tianni , Fang Xiaojie , Lu Jinhua , Zhong Yazhen , Lin Xianlei , Lin Zechen , Wang Nan , Jiang Jing , Lin Shengyou 
Published: October 2021

Abstract
Background and objective
Immune checkpoint inhibitor (ICI) therapies have shown promising prospects in colorectal cancer (CRC) immunotherapy; many clinical trials have been carried out. In this study, we sought to evaluate the efficacy and safety of ICI therapies in CRC by presenting a meta-analysis of relevant studies.

Methods
Databases including PubMed, Embase, Cochrane Library, and Web of Science were systematically searched for studies concerning the efficacy and safety of ICI in colorectal cancer. The reported odds ratio (OR) or weighted mean difference (WMD) with 95% confidence intervals (CIs) of overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), treatment-related adverse events (TRAEs), and TRAEs ≥ 3 in the included studies were analyzed by fixed effects/random effects models.

Results
Three studies involving 667 patients with colorectal cancer were included in our meta-analysis. No significant difference between the immune checkpoint inhibitor therapies and conventional therapies in OS (WMD = 0.73, 95% CI − 3.09, 4.54; p = 0.71), in ORR (OR = 1.54, 95% CI 0.98, 2.40; p = 0.06), and in DCR (OR = 0.97, 95% CI 0.36, 2.61; p = 0.95). The median PFS of the ICI therapy group was shorter than that of the conventional therapy group (WMD =  − 0.10, 95% CI − 0.18, − 0.02; p = 0.02). At the same time, we also could not find a significant difference between the immune checkpoint inhibitor therapies and conventional therapies in TRAEs (OR = 1.56, 95% CI 0.11, 22.09; p = 0.74) and in TRAEs ≥ 3 (OR = 0.94, 95% CI 0.16, 5.65; p = 0.95).

Conclusion
Immune checkpoint inhibitor therapies could not improve all survival endpoints to advanced or metastatic colorectal cancer patients. Whether immune checkpoint inhibitors should be the first choice of therapies for colorectal cancer patients with undetermined microsatellite status or not able to determine microsatellite status needs more related studies to prove.
Knife cut marks inflicted by different blade types and the changes induced by heat: a dimensional and morphological study
Authors: Vachirawongsakorn Vijarn , Painter Jonathan , Márquez-Grant Nicholas 
Published: October 2021

AbstractDetailed information on skeletal trauma analysis of burned bone is important to ascertain the manner and cause of death in forensic casework. This research used three different knife types, one with a non-serrated blade, one a fine-serrated blade, and one a coarse-serrated blade, to inflict trauma to manually maceratedSus scrofaribs (n = 240), and these ribs were later exposed to heat. Qualitative and quantitative analyses were conducted using macroscopic and microscopic techniques to assess specific characteristics of the cut marks. Differences in cut mark dimension and morphology of the ribs were investigated. After heat exposure, the cut marks on the rib samples remained recognisable and did not alter considerably. A level of dimensional and morphological preservation was reliant on the cutting action and the features of the knife blade as well as surrounding bone injury. The cut marks inflicted by the non-serrated blade remained recognisable despite exposure to the burning process. However, the cut marks inflicted by the coarse-serrated blade were likely to change significantly when exposed to heat. This study leads to two important results: (1) identification of pre-existing cut marks prior to heat exposure is possible in reconstructed burned bone fragments, and (2) cut marks from different types of knife blades showed dissimilar responses to heat. The outcomes obtained in this study stressed the need to adopt great care with the effects of heat on skeletal trauma analysis.
Histopathological assessments reveal retinal vascular changes, inflammation, and gliosis in patients with lethal COVID-19
Authors: Jidigam Vijay K. , Singh Rupesh , Batoki Julia C. , Milliner Caroline , Sawant Onkar B. , Bonilha Vera L. , Rao Sujata 
Published: October 2021

Abstract
Purpose
The purpose of this study is to assess for histopathological changes within the retina and the choroid and determine the long-term sequelae of the SARS-CoV-2 infection.

Methods
Eyes from seven COVID-19-positive and six similar age-matched control donors with a negative test for SARS-CoV-2 were assessed. Globes were evaluated ex vivo with macroscopic, SLO and OCT imaging. Macula and peripheral regions were processed for Epon embedding and immunocytochemistry.

Results
Fundus analysis shows hemorrhagic spots and increased vitreous debris in several of the COVID-19 eyes compared to the controls. OCT-based measurements indicated an increased trend in retinal thickness in the COVID-19 eyes; however, the difference was not statistically significant. Histology of the retina showed presence of hemorrhages and central cystoid degeneration in several of the donors. Whole mount analysis of the retina labeled with markers showed changes in retinal microvasculature, increased inflammation, and gliosis in the COVID-19 eyes compared to the controls. The choroidal vasculature displayed localized changes in density and signs of increased inflammation in the COVID-19 samples.

Conclusions
In situ analysis of the retinal tissue suggests that there are severe subclinical abnormalities that could be detected in the COVID-19 eyes. This study provides a rationale for evaluating the ocular physiology of patients that have recovered from COVID-19 infections to further understand the long-term effects caused by this virus.
The creation of phenomena in interactive biorobotics
Authors: Datteri Edoardo 
Published: October 2021

AbstractIn so-called interactive biorobotics, robotic models of living systems interact with animals in controlled experimental settings. By observing how the focal animal reacts to the stimuli delivered by the robot, one tests hypotheses concerning the determinants of animal behaviour in social contexts. Building on previous methodological reconstructions of interactive biorobotics, this article reflects on the claim, made by several authors in the field, that this strategy may enable one to explain social phenomena in animals. The answer offered here will be negative: interactive biorobotics does not contribute to the explanation of social phenomena. However, it may greatly contribute to the study of animal behaviour by creating social phenomena in the sense discussed by Ian Hacking, i.e. by precisely defining new phenomena to be explained. It will be also suggested that interactive biorobotics can be combined with more classical robot-based approaches to the study of living systems, leading to a so-called simulation-interactive strategy for the mechanistic explanation of social behaviour in animals.
White-opaque flowable composite liner as a depth marker in composite restorations prevents tooth substance loss in filling removal: a randomized double-blinded in vitro study
Authors: Wolf Thomas Gerhard , Dekert Natalie , Campus Guglielmo , Ernst Claus-Peter 
Published: October 2021

Abstract
Objectives
Removal of esthetic restorations leads to loss of tooth structure and the extent of the loss is difficult to estimate due to exact-shade matching. This randomized double-blinded in vitro study aimed examining the influence of a white-opaque flowable composite depth marker as an optical removal aid for tooth substance preservation and shortened restoration removal time.

Materials and methods
Class II cavities (n = 100) in extracted healthy mandibular molars (n = 50, two runs) were prepared, filled, and the restoration removed. Tooth weight and volume (before and after) and removal time were measured and remnants visually documented. An optimal tooth shade-matched flowable composite liner was used as control.

Results
Tooth structure loss was significantly lower using a white-opaque liner. Mean values for volume/weight loss were 0.037 ± 0.030 g and 0.016 ± 0.005 cm3 (p < 0.01) for white-opaque liner; 0.067 ± 0.000 g and 0.028 ± 0.003 cm3 (p < 0.01) for tooth-colored composite. Removal time and number of pulp chamber perforations showed no significant differences (p = 0.80).

Conclusions
Within the limitations of this randomized double-blinded in vitro study, the use of a white-opaque flowable liner as a depth marker may provide the practitioner a visual aid in the replacement of a composite restoration and may protect against tooth structure loss.

Clinical relevance
When restoration replacement is indicated, removal of esthetic restorations often causes tooth structure loss due to difficult optical color matching. Using a white-opaque flowable liner as a depth marker clinically aids in restoration removal and protects against tooth structure loss.
Domestic dogs (Canis lupus familiaris) are sensitive to the correlation between pitch and timbre in human speech
Authors: Sturdy Sasha K. , Smith David R. R. , George David N. 
Published: October 2021

AbstractThe perceived pitch of human voices is highly correlated with the fundamental frequency (f0) of the laryngeal source, which is determined largely by the length and mass of the vocal folds. The vocal folds are larger in adult males than in adult females, and men’s voices consequently have a lower pitch than women’s. The length of the supralaryngeal vocal tract (vocal-tract length; VTL) affects the resonant frequencies (formants) of speech which characterize the timbre of the voice. Men’s longer vocal tracts produce lower frequency, and less dispersed, formants than women’s shorter vocal tracts. Pitch and timbre combine to influence the perception of speaker characteristics such as size and age. Together, they can be used to categorize speaker sex with almost perfect accuracy. While it is known that domestic dogs can match a voice to a person of the same sex, there has been no investigation into whether dogs are sensitive to the correlation between pitch and timbre. We recorded a female voice giving three commands (‘Sit’, ‘Lay down’, ‘Come here’), and manipulated the recordings to lower the fundamental frequency (thus lowering pitch), increase simulated VTL (hence affecting timbre), or both (synthesized adult male voice). Dogs responded to the original adult female and synthesized adult male voices equivalently. Their tendency to obey the commands was, however, reduced when either pitch or timbre was manipulated alone. These results suggest that dogs are sensitive to both the pitch and timbre of human voices, and that they learn about the natural covariation of these perceptual attributes.
Fast climatic changes place an endemic Canary Island macroalga at extinction risk
Authors: Alfonso Beatriz , Hernández José Carlos , Sangil Carlos , Martín Laura , Expósito Francisco Javier , Díaz Juan Pedro , Sansón Marta 
Published: October 2021

AbstractGlobal warming and ultraviolet radiation (UVR) affect marine organisms worldwide. However, we still lack knowledge about the consequences of these environmental changes to range-restricted macroalgae species, such asGelidium canariense, a habitat-forming endemic of the Canary Islands. The aim of this study is to provide useful data for analyzing the conservation status of this endemic species. To do this, (1) we compared distributional data from 1987 with the data collected in 2008 and 2019 along the northern coast of Tenerife; (2) we assessed the variation in macroalgae assemblages dominated byG. canarienseover the last decade on this same cost; and (3) we explored the correlation of these results with the actual trends of sea surface temperature (SST), air temperature at 2 m above the sea surface (T2m), UVR, and downward solar radiation (DSR). The results showed significant changes in the distribution ofG. canariensein the last 30 years at Tenerife. More than 90% of its populations have declined. The endemic macroalgae have been replaced by the globally distributed speciesPterocladiella capillaceaat nearly all the sites studied. The cover ofG. canarienseandGelidium arbusculadecreased significantly with increasing SST and T2m. Additionally,G. canarienseis negatively related to the rise in UVR. These results highlight the vulnerability of both species ofGelidiumto global warming and UVR, but especially ofG. canariense. The drastic decline of this species reveals the need to upgrade its conservation status and implement protection measures to reduce the damage that predicted global change scenario may have to their relict populations.
In Vitro Oxidative Crosslinking of Recombinant Barnacle Cyprid Cement Gland Proteins
Authors: Cleverley Robert , Webb David , Middlemiss Stuart , Duke Phillip , Clare Anthony , Okano Keiju , Harwood Colin , Aldred Nick 
Published: October 2021

AbstractBarnacle adhesion is a focus for fouling-control technologies as well as the development of bioinspired adhesives, although the mechanisms remain very poorly understood. The barnacle cypris larva is responsible for surface colonisation. Cyprids release cement from paired glands that contain proteins, carbohydrates and lipids, although further compositional details are scant. Several genes coding for cement gland-specific proteins were identified, but only one of these showed database homology. This was a lysyl oxidase-like protein (lcp_LOX). LOX-like enzymes have been previously identified in the proteome of adult barnacle cement secretory tissue. We attempted to produce recombinant LOX in E. coli, in order to identify its role in cyprid cement polymerisation. We also produced two other cement gland proteins (lcp3_36k_3B8 and lcp2_57k_2F5). lcp2_57k_2F5 contained 56 lysine residues and constituted a plausible substrate for LOX. While significant quantities of soluble lcp3_36k_3B8 and lcp2_57k_2F5 were produced in E. coli, production of stably soluble lcp_LOX failed. A commercially sourced human LOX catalysed the crosslinking of lcp2_57k_2F5 into putative dimers and trimers, and this reaction was inhibited by lcp3_36k_3B8. Inhibition of the lcp_LOX:lcp2_57k_2F5 reaction by lcp3_36k_3B8 appeared to be substrate specific, with no inhibitory effect on the oxidation of cadaverine by LOX. The results demonstrate a possible curing mechanism for barnacle cyprid cement and, thus, provide a basis for a more complete understanding of larval adhesion for targeted control of marine biofouling and adhesives for niche applications.
On the relation of the lunar recession and the length-of-the-day
Authors: Maeder Andre M. , Gueorguiev Vesselin G. 
Published: October 2021

AbstractWe review the problem of the consistency between the observed values of the lunar recession from Lunar Laser Ranging (LLR) and of the increase of the length-of-the-day (LOD). From observations of lunar occultations completed by recent IERS data, we derive a variation rate of the LOD equal to 1.09 ms/cy from 1680 to 2020, which compares well with McCarthy and Babcock (Phys. Earth Planet. Inter. 44: 281, 1986) and Sidorenkov (Astron. Astrophys. Trans. 24: 425, 2005). This rate is lower than the mean rate of 1.78 ms/cy derived by Stephenson et al. (Proc. R. Soc. A 472: 20160404, 2016) on the basis of eclipses in the Antiquity and Middle Age. The difference in the two observed rates starts at the epoch of a major change in the data accuracy with telescopic observations. The observed lunar recession appears too large when compared to the tidal slowing down of the Earth determined from eclipses in the Antiquity and Middle Age and even much more when determined from lunar occultations and IERS data from 1680 to 2020. With a proper account of the tidal effects and of the detailed studies on the atmospheric effects, the melting from icefields, the changes of the sea level, the glacial isostatic adjustment, and the core-mantle coupling, we conclude that the long-standing problem of the presence or absence of a local cosmological expansion is still an open question.
User encoding for clustering in very sparse recommender systems tasks
Authors: Pérez-Núnez Pablo , Díez Jorge , Luaces Oscar , Bahamonde Antonio 
Published: October 2021

AbstractRecommender Systems are a very useful tool which let companies and service providers focus in the preferences of their customers, helping them to avoid an overwhelming variety of choices. In this context, clustering tools can play an important role to detect groups of customers with similar tastes. Thus, companies can make personalized marketing campaigns, offering to their users new products which have been consumed by other users with comparable preferences. In this paper we present a general framework to cluster users with respect to their tastes when the registers stored about the interactions between users and products are extremely scarce. Commonly, clustering methods employ the values of features describing the samples to be clustered (users in our case), but such features are not always available. We propose some alternative representations for users, in which their tastes are gathered to some extent, so that clustering algorithms can take advantage and make more homogeneous groups in this regard. To illustrate the performance of the whole framework, we tested it on six popular datasets commonly used as a benchmark for recommender systems, as well as on an extremely sparse real-world dataset that records the preferences of readers to click promoted links in digital publications. In the experimental section we compare our proposed representations to other common user encodings. We show that clustering users attending only to their feature values or to the items they have evaluated gives rise to the worst scores in terms of taste homogeneity.
Determining the Spatial Pattern of Blackleg Diseased Potato Plants in the Field and Simulated Post-Harvest Tuber Infections in Potato Crates
Authors: Been Thomas H. , Beniers Johanna E. , van der Wolf Jan M. 
Published: October 2021

Abstract
Experiments were carried out in 2012 and 2013 to answer two basic questions in the testing of potato blackleg causing agents before and after harvest. Firstly, what is the spatial distribution of symptomatic plants in the field. Secondly, what is the distribution of infected tubers over the crates and the resulting detection probability using the standard method of collecting 200 tubers from the top crates in storage. In both years, ten farmers were equipped with a global positioning system (Garmin GPSMAP 62) and asked to register the position of blackleg diseased plants every time they scouted their potato lot for diseases. To answer the second question, potatoes marked with four nails (only visible internally after harvest) and potatoes with a different skin colour were added to one-hectare (ha) fields of seed potatoes in different patterns of aggregation ranging from random, to aggregated distribution, up to one big hotspot prior to harvest. The invisibly marked tubers were used for the unbiased collection of twenty 200-tuber samples from the storage crates, while the coloured skin tubers were used to ascertain, when the potatoes were graded, the distribution of ‘infected’ potatoes over the storage crates. The experiment was carried out with 0.05 and 0.1% disease incidence, in 2012 and 2013, respectively. Twenty two out of 26 fields proved to have a random pattern of diseased plants at harvest, which indicates that the blackleg diseased plants came into the field as infected seed potatoes. Two of the four aggregated patterns detected, started out as random distributions but became aggregated later in time, indicating spread in the field. A random spatial pattern in the field at harvest proved to result in a uniform distribution of infected tubers in the crates and, consequently, sampling of only the top crates for the 200-tuber sample does not introduce any bias. Fifty percent of the infected farmer lots were detected by the Nederlandse Algemene Keuringsdienst inspectors performing their official field surveys, which was a better performance than the 18% detection obtained by the standard 200-tuber sampling method. Only 6 out of 80 samples from the ‘infected’ lots with 0.05% disease incidence level, and 22 out of 80 samples at the 0.1% disease incidence level were detected by the latter method. It was concluded that intensifying the field survey would be cheaper and more successful than enlarging the tuber sample size to increase the probability for detection of infected seed lots.