bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of orbital complications in outpatients presenting with severe rhinosinusitis: A case‐control study
Authors: Snidvongs Kornkiat , Chitsuthipakorn Wirach , Akarapas Chatdanai , Aeumjaturapat Songklot , Chusakul Supinda , Kanjanaumporn Jesada , Seresirikachorn Kachorn 
Published: January 2021

AbstractObjectivesWe assessed associations of potential factors with orbital complications in acute rhinosinusitis (ARS) patients.DesignAn unmatched case‐control study.SettingA tertiary referral hospital in Thailand.ParticipantsConsecutive outpatients of any age with severe ARS (visual analog scale ≥ 7) with and without orbital complications.Main outcome measuresPatients were enrolled from January 2013 to December 2018. Forty‐three ARS patients (55.8% female, median age 45.6, (range 2.0‐93.0) years) were included, with 19 patients in the complicated group and 24 in the uncomplicated group. Patient characteristics (gender, age, diabetes, immune status), symptoms and signs, site of infection and type of pathogenic bacteria were recorded and assessed their associations with orbital complications by univariable and multivariable logistic regression analyses. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsThe most common orbital complication was subperiosteal abscess (42.1%), followed by orbital cellulitis (15.8%) and cavernous sinus thrombosis (10.5%). Multivariable logistic regression analysis demonstrated a positive association with orbital complications (pseudo R2 0.4) for ethmoid sinusitis (OR 31.1, 95% CI [2.3‐430.6]) and a short duration of symptoms (OR 0.9, 95% CI [0.8‐0.9]).ConclusionsOrbital complications were associated with ethmoid sinusitis with a short duration of ARS symptoms.
Decrease of contact allergy to hydroxyisohexyl 3‐cyclohexene carboxaldehyde in Europe prior to its ban and diagnostic value
Authors: Ahlström Malin G. , Uter Wolfgang , Ahlström Magnus G. , Johansen Jeanne D. 
Published: January 2021

AbstractBackgroundHydroxyisohexyl 3‐cyclohexene carboxaldehyde (HICC) has been the most reported fragrance chemical for two decades and will be prohibited in cosmetic products from August 2021.ObjectivesTo describe the time trend of HICC contact allergy in European patients with dermatitis in 2009 to 2019, and the added value of testing HICC separately in the baseline series.MethodsData were reviewed for 124 472 patients with dermatitis who were patch tested with HICC 5% pet. in the baseline series in the European Surveillance System on Contact Allergy (ESSCA) network (2009 to 2018) and at the Herlev‐Gentofte Hospital Department of Dermatology and Allergy (2009 to 2019).ResultsContact allergy to HICC was found in 1.98% of 9865 patients in Gentofte and 1.62% of 114 607 patients in the ESSCA network. Overall, the prevalence decreased annually, with 0.156 percentage points (P = .001) in Gentofte and 0.051 percentage points (P = .0002) in ESSCA. The frequency of missed contact allergy to HICC when testing only with fragrance mix II (FMII) was 0.17% (17/9865) and 0.35% (405/114607) of the whole test population in the Gentofte and ESSCA populations, respectively.ConclusionsThis is the first study to demonstrate a significant decline in HICC allergy in European patients with dermatitis, most likely attributed to the upcoming European ban.
Word Order Predicts Cross‐Linguistic Differences in the Production of Redundant Color and Number Modifiers
Authors: Wu Sarah A. , Gibson Edward 
Published: January 2021

AbstractWhen asked to identify objects having unique shapes and colors among other objects, English speakers often produce redundant color modifiers (“the red circle”) while Spanish speakers produce them less often (“el circulo (rojo)”). This cross‐linguistic difference has been attributed to a difference in word order between the two languages, under the incremental efficiency hypothesis (Rubio‐Fernández, Mollica, & Jara‐Ettinger, 2020). However, previous studies leave open the possibility that broad language differences between English and Spanish may explain this cross‐linguistic difference such that English speakers may generally produce more modifiers than Spanish speakers, including redundant ones, irrespective of word order. Here, we test the incremental efficiency hypothesis in a language production task crossing language (English, Spanish) with modifier type (color, number). Critically, number words occur on the same side of the noun in both English and Spanish. If broad language differences are responsible for the higher rate of color word production in English compared to Spanish, then the same effect should hold for number words. In contrast, the incremental efficiency hypothesis predicts an interaction between language and modifier type, due to different ordering for color words but identical ordering for number words. Our pre‐registered analyses offer strong support for the incremental efficiency hypothesis, demonstrating how seemingly small differences in language can cause us to describe the world in surprisingly different ways.
Brain, cognition, and language development in spinal muscular atrophy type 1: a scoping review
Authors: Masson Riccardo , Brusa Chiara , Scoto Mariacristina , Baranello Giovanni 
Published: January 2021

AimTo summarize the current knowledge on brain involvement in spinal muscular atrophy (SMA) type 1, focusing on brain pathology, cognition, and speech/language development.MethodA scoping review was performed using the methodology of the Joanna Briggs Institute. Five databases and references from relevant articles were searched up to December 2019. Articles were screened on the basis of titles and abstracts. Full‐text papers published in peer‐reviewed journals in English were selected.ResultsNineteen articles met eligibility criteria. Eight case series/reports on brain pathology showed abnormalities in few SMA type 0/1 cases, supported by findings in three post‐mortem examinations in mice. Four studies (three case–control, one cross‐sectional) on cognition reported contradictory results, with impaired cognitive performances in recent, small groups with SMA type 1. Four studies (three cross‐sectional, one observational) on speech/language showed that untreated SMA type 1 patients rarely achieve functional and intelligible speech, with data limited to parent reports/non‐formal evaluations.InterpretationBrain involvement is an under‐investigated aspect of SMA type 1, requiring further exploration in longitudinal studies. A deeper knowledge of brain involvement would improve the interpretation of clinical phenotypes and the personalization of rehabilitation programmes supporting patients' autonomies and quality of life. Additionally, it may help to define further outcome measures testing the efficacy of current and new developing drugs on this domain.What this paper adds

Brain involvement is under‐investigated in spinal muscular atrophy (SMA) type 1.

Neuropathological data suggest progressive brain involvement in severe forms of SMA.

Impaired cognitive performances are reported in small groups with SMA type 1.

Data on language in those with SMA type 1 are limited to parent reports and non‐formal assessments.
More change in task repetition, less cost in task switching: Behavioral and event‐related potential evidence
Authors: Zhuo Bingxin , Zhu Mengqi , Cao Bihua , Li Fuhong 
Published: January 2021

AbstractPrevious studies have shown that the probability of task switching can vary the level of cognitive control and modulate the size of switch costs. However, it is unclear whether switch costs would be affected by a task‐repetition context formed by varying the degree of response (and task‐relevant stimulus property) change within the task repetition sequences while the probability of task switching remains constant. In the present study, participants were presented with a string of digits (e.g., ②②②). Basing on stimulus color, they were required to indicate either the presented digit, or the number of presented digits. Before task switching, stimulus and response in consecutive task‐repeat trials varied more or less frequently. Behavioral results showed that the frequent‐change context elicited smaller switch costs than the rare‐change context. Event‐related potential (ERP) results indicated that: (1) the frequent‐change context evoked greater fronto‐central N2 amplitudes for both task‐repeat and task‐switch trials, implying that cognitive control increased due to the variation of stimulus and response associations; (2) for the task switch trials, smaller P300 amplitudes were evoked in the frequent‐change context than the rare‐change context, reflecting the promoted task‐set reconfiguration. These findings suggest that, the more change in stimulus and response during task repetition, the higher the overall level of cognitive control and the higher efficiency of task‐switching.
Temporal orienting in Parkinson’s disease
Authors: Zokaei Nahid , Gillebert Celine R. , Chauvin Joshua J. , Gresch Daniela , Board Alexander G. , Rolinski Michal , Hu Michele T. , Nobre Anna Christina 
Published: January 2021

AbstractTemporal orienting of attention can affect multiple stages of processing to guide adaptive behaviour. We tested whether temporal expectation in different task contexts is compromised in individuals with Parkinson's disease (PD). In Experiment 1 two temporal‐orienting tasks were used: a speeded task emphasizing motor preparation and a non‐speeded task emphasizing perceptual discrimination using rapid serial visual presentation. In both tasks, auditory cues indicated the likelihood of a target appearing after a short or long interval. In the speeded‐response task, participants used the cues to anticipate an easily detectable target stimulus. In the non‐speeded perceptual‐discrimination task, participants used the cues to help discriminate a target letter embedded in a stream of letters. Relative to healthy participants, participants with PD did not show altered temporal orienting effects in the speeded‐response task. However, they were impaired in using temporal cues to improve perceptual discrimination. In Experiment 2, we tested whether the temporal‐orienting deficits in the perceptual‐discrimination task depended on the requirement to ignore temporally distracting stimuli. We replicated the impaired temporal orienting for perceptual discrimination in an independent group of individuals with PD, and showed the impairment was abolished when individuals were on their dopaminergic medication. In a task without any distracting letters, however, patients off or on medication benefited normally from temporal orienting cues. Our findings suggest that deficits in temporal orienting in individuals with PD interact with specific task demands, such as the requirement to select target from temporally competing distractors.
The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease
Authors: Zimmermann Milan , Köhler Leonie , Kovarova Marketa , Lerche Stefanie , Schulte Claudia , Wurster Isabel , Machetanz Gerrit , Deuschle Christian , Hauser Ann‐Kathrin , Gasser Thomas , Berg Daniela , Schleicher Erwin , Maetzler Walter , Brockmann Kathrin 
Published: January 2021

AbstractBackgroundParkinson´s disease (PD) has a large phenotypic variability, which may, at least partly, be genetically driven including alterations of gene products. Candidates might not only be proteins associated with disease risk but also pathways that play a role in aging.ObjectiveTo evaluate phenotype‐modifying effects of genetic variants in Klotho, a longevity gene.MethodsWe analyzed two longitudinal cohorts: one local cohort comprising 459 PD patients who underwent genotyping for the KL‐VS haplotype in Klotho including a subgroup of 125 PD patients and 50 healthy controls who underwent biochemical cerebrospinal fluid (CSF) analyses of Klotho and fibroblast growth factor 23 as well as vitamin D metabolites. The second cohort comprised 297 patients from the Parkinsonʼs Progression Markers Initiative (PPMI) for validation of genetic−clinical findings.ResultsPD patients carrying the KL‐VS haplotype demonstrated a shorter interval between PD onset and onset of cognitive impairment (both cohorts) and higher Unified Parkinson´s Disease Rating Scale part III (UPDRS III) scores (PPMI). CSF protein levels of Klotho and fibroblast growth factor 23 were lower in PD patients irrespective of gender compared to controls. Moreover, low CSF levels of Klotho were associated with higher scores in the UPDRS III and Hoehn and Yahr Scale.ConclusionsOur results indicate that genetic variants in Klotho together with its corresponding CSF protein profiles are associated with aspects of disease severity in PD. These findings suggest that pathways associated with aging might be targets for future biomarker research in PD.
Over‐expression of stromal periostin correlates with poor prognosis of cutaneous squamous cell carcinomas
Authors: Lincoln Vadim , Chao Lyu , Woodley David T. , Murrell Dedee , Kim Minhee , O'Toole Edel A. , Ly Alexandre , Cogan Jon , Mosallaei Daniel , Wysong Ashley , Chen Mei 
Published: January 2021

AbstractPeriostin, an extracellular matrix macromolecule implicated in tumorigenesis, serves as a prognostic marker for many cancer types. However, there are no data on periostin expression in cutaneous squamous cell carcinoma (cSCC). This study examined periostin expression in patients with cSCC and explored its clincopathological relationship and prognosis. Using immunohistochemistry and ImageJ analysis, we compared periostin expression in 95 cSCCs across a spectrum of cSCC aggressiveness: cSCC in situ (SCCIS) (n = 25), low‐risk cSCC (LR‐cSCC) (n = 26), high‐risk cSCC (HR‐cSCC) (n = 38), and cSCC in recessive dystrophic epidermolysis bullosa patients (RDEB cSCC) (n = 6). Immunohistochemistry demonstrated periostin expression within the intra‐tumoral stroma but not within tumor cells. Periostin levels significantly (P < 0.001) increased from SCCIS, LR‐cSCC, HR‐cSCC to RDEB SCC. The stroma of most of the cSCCs we evaluated contained cancer‐associated fibroblasts with a myofibroblastic (α ‐SMA‐positive) phenotype. Co‐localization of periostin with α‐SMA, evidence of fibroblast periostin expression, and absence of keratinocyte or tumor cell periostin expression suggest that, in cSCC, periostin is a product of the peritumoral microenvironment and not the tumor cells themselves. Our data indicate that fibroblast periostin expression is highly correlated with the aggressiveness of cSCC, and may thereby provide a molecular marker that will be useful for subtyping and diagnosing cSCCs according to their biological nature.
Environmental drivers of plant distributions at global and regional scales
Authors: Huang Erhan , Chen Yuxin , Fang Miao , Zheng Yi , Yu Shixiao 
Published: January 2021

AbstractAimHow environmental factors drive plant distribution across the globe is one of the most fundamental questions in ecology. Nevertheless, the relative importance of different environmental factors in driving plant distributions across spatial scales and among plant groups is not clear. This study aims to disentangle how plant–environment relationships vary with latitude and among plant taxa.LocationGlobal.Time periodPresent day.Main taxaPlant taxa including angiosperms, gymnosperms, pteridophytes and bryophytes.MethodsWe obtained global distribution occurrence data of mass plant groups (625 families, 6,221 genera, and 54,101 species) from the Global Biodiversity Information Facility (GBIF) database. We used random forest method to quantify the relative effects of 15 environmental factors (including climate, soil and topography) on plant distributions at global and regional scales (divided into different latitude zones). We also used phylogenetic generalized least squares (PGLS) models to investigate the relationships between environmental variables and geographical range size, latitudinal range and limits of plants at the global scale.ResultsOur analyses revealed the primacy of the effects of climatic variability (temperature seasonality and isothermality) on plant distribution at the global scale. The relative contributions of temperature seasonality and isothermality peaked in tropical areas, whereas solar radiation and annual mean temperature had stronger influence in high‐latitude areas. Wide‐range plant groups tended to occur in areas with higher temperature variability (isothermality and temperature seasonality) and flatter terrain (low slope). Both climate variability and extreme influenced geographical range size, latitudinal range and limits of plants.Main conclusionsOur study highlights the significance of climate variability for global plant distributions. Environmental effects upon plant distributions vary across latitudes. The findings imply that environmental factors affecting plant distributions change with geographical scales, suggesting that different geographical and ecological processes should be integrated to explain multi‐scale distribution patterns.
Permeability coefficients and vapour pressure determination for fragrance materials
Authors: Almeida Rafael N. , Hartz João G.M. , Costa Patrícia F. , Rodrigues Alírio E. , Vargas Rubem M.F. , Cassel Eduardo 
Published: January 2021

AbstractObjectiveThis study aims to correlate new experimental data relevant to the description of the combined evaporation/permeation process of a perfume applied onto the skin.MethodsThe vapour pressure data were measured by thermogravimetric analysis (TG‐DTA). The Antoine constants and the Clarke and Glew parameters were determined for the same set of fragrance molecules to describe its low vapour pressures at new temperature ranges. The permeability coefficient of a set of 14 fragrance molecules in ethanolic solution was determined by Franz diffusion cell experiments, using porcine skin. The samples were analysed by gas chromatography with a flame ionization detector (GC/FID) and high‐performance liquid chromatography with UV visible detector (HPLC/UV). A QSAR model was proposed to correlate the experimental data.ResultsThe Antoine constants were determined and presented low standard deviations. The Clarke and Glew physically significant parameters were obtained along with its statistical analysis. The fitting is good since the magnitude order is in accordance with the literature, associated with the low correlation between the estimated parameters and low standard deviations. The presented correlation, based on a mixture using only ethanol as solvent, showed better results than previous QSAR models with a standard relative deviation (of 0.190, a standard error (SE) of 0.397 and a determination coefficient (R2) of 0.7786.ConclusionThe dataset is still small compared to larger and more general QSAR models; however, it is much more specific as to the type of solvent and class of materials studied. This work represents an advance for the modelling of the perfume diffusion process since it specifies important properties that until then had been treated in a more general way.
PRIASE 2021 guidelines for reporting animal studies in Endodontology: a consensus‐based development
Authors: Nagendrababu V. , Kishen A. , Murray P. E. , Nekoofar M. H. , de Figueiredo J. A. P. , Priya E. , Jayaraman J. , Pulikkotil S. J. , Camilleri J. , Silva R. M. , Dummer P. M. H. 
Published: January 2021

AbstractAnimal testing is crucial in situations when research on humans is not allowed because of unknown health risks and ethical concerns. The current project aims to develop reporting guidelines exclusively for animal studies in Endodontology, using an established consensus‐based methodology. The guidelines have been named: Preferred Reporting Items for Animal Studies in Endodontology (PRIASE) 2021. Nine individuals (PD, VN, AK, PM, MN, JF, EP, JJ and SJ), including the project leaders (PD, VN) formed a steering committee. The steering committee developed a novel checklist by adapting and integrating their animal testing and peer review experience with the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines and also the Clinical and Laboratory Images in Publications (CLIP) principles. A PRIASE Delphi Group (PDG) and PRIASE Online Meeting Group (POMG) were also formed. Thirty‐one PDG members participated in the online Delphi process and achieved consensus on the checklist items and flowchart that were used to formulate the PRIASE guidelines. The novel PRIASE 2021 guidelines were discussed with the POMG on 9 September 2020 via a Zoom online video call attended by 21 individuals from across the globe and seven steering committee members. Following the discussions, the guidelines were modified and then piloted by several authors whilst writing a manuscript involving research on animals. The PRIASE 2021 guidelines are a checklist consisting of 11 domains and 43 individual items together with a flowchart. The PRIASE 2021 guidelines are focused on improving the methodological principles, reproducibility and quality of animal studies in order to enhance their reliability as well as repeatability to estimate the effects of endodontic treatments and usefulness for guiding future clinical studies on humans.
The top‐trading cycles and chains solution for kidney exchange with immunosuppressants
Authors: Heo Eun Jeong , Hong Sunghoon , Chun Youngsub 
Published: January 2021

AbstractIn kidney transplantation, immunosuppressants are being used to relax all immunological constraints, allowing patients to receive transplants from biologically incompatible donors. We propose an efficient way of using immunosuppressants in combination with a kidney exchange program. We introduce the top‐trading cycles and chains solution, a modification of the top‐trading cycles rule for the standard kidney exchange problem, and investigate its properties.
Effect of slightly acidic electrolysed water on functional components, antioxidant and α‐glucosidase inhibitory ability of buckwheat sprouts
Authors: Hao Jianxiong , Li Jiaxin , Zhao Dandan 
Published: January 2021

SummaryThe effect of slightly acidic electrolysed water (SAEW) on the accumulation of total phenolics (TP), total flavonoids (TF), rutin, quercetin and D‐chiro‐inositol (DCI), the antioxidant and α‐glucosidase inhibitory abilities of germinated buckwheat was investigated. The buckwheat treated in low available chlorine concentration (ACC) of 10.94 mg L‐1 displayed the best accumulation of the bioactive substance, showing 63.0%, 113.07% and 128.1% higher TP, TF and rutin content on the 9th day, respectively, and 163.5% and 113.4% higher quercetin and DCI content on the 7th day, respectively, compared to control. Seven‐day sprouts treated with SAEW had markedly stronger ABTS radical scavenging and α‐glucosidase inhibitory capacities compared to the other treatments. SAEW with lower ACC had less adverse impact on the length and fresh weight of buckwheat than SAEW with higher ACC. Buckwheat sprouts should be treated by SAEW with lower ACC and harvested on the 7th day as for enhanced health‐promoting benefits.