bluuebunny/crossref_metadata_2025_split huggingface dataset:
A influência midiática para automedicação do novo coronavírus: revisão literária
Authors: Ruiz Juliana Matos Gomes , Souza Érica Ferreira de , Paiva Maykon Jhuly Martins de 
Published: October 2021

A automedicação e uma hábito adotado pelos idivíduos que em muitas vezes acabam optando por este método em busca de uma alívio rápido para seus males. No final de 2019 o SARS-CoV-2 foi descoberto após casos registrados na China, com relatos que incluíam sintomas respiratórios leves e persistentes característicos da COVID-19. É notório que diante deste cenário houve uma grande influência da mídia para o uso de medicamentos como um suposto tratamento imediato, mesmo não havendo uma eficácia comprovada cientificamente. O aumento da automedicação é algo histórico em toda a humanidade, pessoas doentes que têm pouco acesso a estudos científicos e saúde de qualidade constantemente optam por se automedicarem sem prescrição médica. Durante a pandemia do novo coronavírus, várias falsas notícias apontam medicamentos milagrosos para tratar a doença da COVID – 19, porém, são cientificamente ineficazes e pouco provados. O uso de medicamentos sem prescrição médica é um risco para a saúde de quem costuma aderir essas práticas. Este artigo de revisão literária tem como objetivo geral identificar os motivos da automedicação durante a pandemia do coronavírus e os principais riscos da utilização de medicamentos sem prescrição médica.
A influência da incontinência urinária na qualidade de vida de mulheres jovens: uma revisão de literatura
Authors: Souza Bruna Ribeiro de , Dantas Isabely dos Santos , Souza Janglea Sousa de , Alencar Indiara de 
Published: October 2021

A incontinência urinária (IU) está entre uma das situações que diminuem a qualidade de vida das mulheres, devido ao comprometimento em várias áreas da vida, o que deixa a mulher vulnerável a vários problemas por conta das restrições que as limitam. A incontinência urinária não é uma patologia específica de mulheres idosas, visto que o número de mulheres jovens com essa disfunção tem se tornado relevante afetando as mulheres em diversas fases do ciclo vital. A IU está entre uma das situações que diminuem a qualidade de vida das mulheres, devido ao comprometimento em várias áreas da vida, como físico, social e principalmente psicológico, o que leva a limitação de atividades sociais e familiares. Devido a falta de informação, muitas mulheres acham que não existe tratamento e imaginam que é normal esse escape de urina. Como metodologia do estudo buscou-se reunir artigos que apresentaram importância no campo científico sobre o tema proposto. Apesar de serem poucos o número de estudos encontrados, podemos concluir que a incontinência urinária afeta de forma negativa a qualidade de vida das mulheres, principalmente no que diz respeito ao âmbito psicológico, incapacitando-as de realizar de forma adequada suas atividades de vida diária.
A importância do profissional da nutrição na orientação adequada dos praticantes do vegetarianismo
Authors: Vasconcelos Bruna Karine Bastos de , Farias Monique dos Santos , Silva Daize Milena Costa da , Freitas Francisca Marta Nascimento de Oliveira 
Published: October 2021

Introdução: No ramo da alimentação vegetariana pode-se identificar várias diferenças dessa prática. O termo vegetarianismo em si remete a uma dieta isenta de carne animal. Objetivo Geral: O presente artigo é parte de uma pesquisa que tem como objetivo mostrar os diferentes aspectos da prática do veganismo e vegetarianismo, seu impacto na saúde, e a influência do nutricionista nessa prática. Assim como descrever os nutrientes na composição alimentar e recomendação na dieta vegetariana. Metodologia: O trabalho foi desenvolvido com coleta de dados a parti de fontes segundarias, por meio de levantamento bibliográfico e baseado no estudo de autores e suas pesquisas sobre o vegetarianismo e o impacto na saúde humana. Resultado e discussão: Para realização desse estudo foi desenvolvido com base nos artigos o impacto deste tipo de dieta na vida adulta. Estas pesquisas foram realizadas em base de artigos científicos, publicações acadêmicas e periódicos científicos, em maioria dos últimos 10 anos. Também foram utilizados livros acadêmicos e científicos como material de consulta. Conclusão: Conclui-se com realização desse projeto orientar os indivíduos vegetarianos sobre a importância do nutricionista ao iniciar esse tipo de alimentação, pontuando os riscos da falta de informação que pode causar inúmeras desordens alimentares, como as deficiências nutricionais que podem ser supridas tanto pela dieta, adequando os nutrientes e respeitando as recomendações quanto, e se preciso, fazer o uso da suplementação.
Como os indicadores sociais e ambientais influenciam as taxas de suicídio - uma análise estatística
Authors: Ferreira Maurielle de Casto , Silva Maguylene Rosa da , Fernandes Daniela Aparecida Araujo , Jaconi Angélica , Rambo Magale Karine 
Published: October 2021

Uma análise multivariada de dados, avaliando os parâmetros sociais e ambientais do estado do Tocantins, mais especificamente da capital, Palmas, foi utilizada como forma de entender as causas das violências autoprovocadas - os suicídios. Os resultados estatísticos apresentaram forte relação entre as variáveis faixa etária, ocupação e sexo, enquanto que a variável escolaridade não apresentou grande influência. Já as variáveis ocupação e faixa etária, com 20,7% da variância, estão altamente correlacionadas. As variáveis escolaridade, raça/cor, tipo de óbito e local da ocorrência não apresentaram distinção entre as amostras. É importante destacar, que para mudança da realidade de saúde se faz necessário fortalecer as Políticas de Redução da Morbimortalidade por Acidentes e Violências e de Promoção de Saúde a fim de promover equidade e a melhoria das condições dos modos de viver, potencializando a saúde e reduzindo vulnerabilidades e riscos decorrentes dos determinantes sociais, econômicos, políticos e ambientais.
Qualitative and Quantitative Assessments of Blood Flow on Tears in Type B Aortic Dissection With Different Morphologies
Authors: Saitta Simone , Guo Baolei , Pirola Selene , Menichini Claudia , Guo Daqiao , Shan Yan , Dong Zhihui , Xu Xiao Yun , Fu Weiguo 
Published: October 2021

Objective: The interactions between aortic morphology and hemodynamics play a key role in determining type B aortic dissection (TBAD) progression and remodeling. The study aimed to provide qualitative and quantitative hemodynamic assessment in four different TBAD morphologies based on 4D flow MRI analysis.Materials and Methods: Four patients with different TBAD morphologies underwent CT and 4D flow MRI scans. Qualitative blood flow evaluation was performed by visualizing velocity streamlines and flow directionality near the tears. Quantitative analysis included flow rate, velocity and reverse flow index (RFI) measurements. Statistical analysis was performed to evaluate hemodynamic differences between the true lumen (TL) and false lumen (FL) of patients.Results: Qualitative analysis revealed blood flow splitting near the primary entry tears (PETs), often causing the formation of vortices in the FL. All patients exhibited clear hemodynamic differences between TL and FL, with the TL generally showing higher velocities and flow rates, and lower RFIs. Average velocity magnitude measurements were significantly different for Patient 1 (t = 5.61, p = 0.001), Patient 2 (t = 3.09, p = 0.02) and Patient 4 (t = 2.81, p = 0.03). At follow-up, Patient three suffered from left renal ischemia because of FL collapse. This patient presented a complex morphology with two FLs and marked flow differences between TL and FLs. In Patient 4, left renal artery malperfusion was observed at the 32-months follow-up, due to FL thrombosis growing after PET repair.Conclusion: The study demonstrates the clinical feasibility of using 4D flow MRI in the context of TBAD. Detailed patient-specific hemodynamics assessment before treatment may provide useful insights to better understand this pathology in the future.
Quantifying the Impact of Ultraviolet Subtype C in Reducing Airborne Pathogen Transmission and Improving Energy Efficiency in Healthy Buildings: A Kahn–Mariita Equivalent Ventilation Model
Authors: Kahn Kevin , Mariita Richard M. 
Published: October 2021

There is growing evidence that viruses responsible for pandemics, such as Middle East respiratory syndrome and severe acute respiratory syndrome, are mainly spread through aerosols. Recommendations have been introduced to reduce the transmission risks of virulent airborne viral particles by increasing ventilation rates, expressed in air changes per hour (ACHs), effectively improving the dilution of pathogens via mechanical ventilation. However, infrastructural and operational costs associated with upgrades of building heating, ventilation, and air conditioning systems make these solutions expensive. It is well documented that Ultraviolet Subtype C (UVC) disinfection can help lower exposure risks by inactivating viruses and the performance of such solutions can translate into equivalent ventilation. Here, we present the first framework to extract the optimal UVC requirements to improve facility management yet ensuring compliance with ventilation guidelines at lower energy costs. The Kahn–Mariita (KM) model considers the air quality of shared enclosed spaces over time by supplementing the existing mechanical ventilation with localized UVC air treatment and includes variables such as room size, occupancy, existing ventilation, and target equivalent ACH. For example, the model applied to a conference room shows that a UVC chamber with recirculation rates of 160 m3/h increases ventilation from an ACH 3 to 7.9 and reduces the room’s reset time from 46 to &lt;10 min with as little as 1 W. Recirculation rates of 30 m3/h however offer no benefits beyond 200 mW, with an eACH of 3.9 and reset time of 31 min. The first finding is that single-pass disinfection is not an appropriate metric of performance, i.e., low recirculation rates increase single-pass disinfection, and, however, only treats a portion of the space volume within a given time, limiting the overall performance. Conversely, higher recirculation rates decrease single-pass disinfection but treat larger portions of air, potentially multiple times, and are therefore expected to lower the transmission risk faster. The second result is that for fixed amounts of recirculating air flow, increasing UVC power helps with diminishing return, while for a fixed UVC power, increasing the recirculating air flow will always help. This dynamic is particularly important toward optimizing solutions, given the constraints system engineers must work with, and particularly to design for end-user benefits such as increased occupancy, in-dwelling time, or reduction of shared-space reset time.
Auditory Neuropathy as the Initial Phenotype for Patients With ATP1A3 c.2452 G > A: Genotype–Phenotype Study and CI Management
Authors: Wang Wenjia , Li Jin , Lan Lan , Xie Linyi , Xiong Fen , Guan Jing , Wang Hongyang , Wang Qiuju 
Published: October 2021

Objective: The objective of this study is to analyze the genotype–phenotype correlation of patients with auditory neuropathy (AN), which is a clinical condition featuring normal cochlear responses and abnormal neural responses, and ATP1A3 c.2452 G &gt; A (p.E818K), which has been generally recognized as a genetic cause of cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS) syndrome.Methods: Four patients diagnosed as AN by clinical evaluation and otoacoustic emission and auditory brainstem responses were recruited and analyzed by next-generation sequencing to identify candidate disease-causing variants. Sanger sequencing was performed on the patients and their parents to verify the results, and short tandem repeat-based testing was conducted to confirm the biological relationship between the parents and the patients. Furthermore, cochlear implantation (CI) was performed in one AN patient to reconstruct hearing.Results: Four subjects with AN were identified to share a de novo variant, p.E818K in the ATP1A3 gene. Except for the AN phenotype, patients 1 and 2 exhibited varying degrees of neurological symptoms, implying that they can be diagnosed as CAPOS syndrome. During the 15 years follow-up of patient 1, we observed delayed neurological events and progressive bilateral sensorineural hearing loss in pure tone threshold (pure tone audiometry, PTA). Patient 2 underwent CI on his left ear, and the result was poor. The other two patients (patient 3 and patient 4, who were 8 and 6 years old, respectively) denied any neurological symptoms.Conclusion:ATP1A3 p.E818K has rarely been documented in the Chinese AN population. Our study confirms that p.E818K in the ATP1A3 gene is a multiethnic cause of AN in Chinese individuals. Our study further demonstrates the significance of genetic testing for this specific mutation for identifying the special subtype of AN with somewhat favorable CI outcome and offers a more accurate genetic counseling about the specific de novo mutation.
Hypoglycemia Among Type 1 Diabetes Patients After Insulin Use in Southwest Ethiopia
Authors: Yosef Tewodros 
Published: October 2021

IntroductionGlycemic control is a valuable goal for people with diabetes; however, the greatest challenge to achieving tight glycemic control is hypoglycemia. Hypoglycemic events are probably common in type 1 diabetes; however, little is known about hypoglycemia in Ethiopia. Therefore, this study aimed to assess the prevalence and the associated factors of hypoglycemia among type 1 diabetes (T1D) patients after insulin use at Metu Karl Referral Hospital in southwest Ethiopia.Materials and MethodsA hospital-based cross-sectional study was conducted among 242 T1D patients at Metu Karl Referral Hospital in southwest Ethiopia. The prevalence of hypoglycemia was assessed by a structured questionnaire through a face-to-face interview in which all the possible symptoms of hypoglycemia were included. If the patients reported that they had experienced the symptoms at least two times in a month and the symptoms were relieved upon consuming sugar/candy/honey, such cases were considered to have had a hypoglycemic episode. Binary logistic regression analysis was done to identify the factors associated with the occurrence of hypoglycemia.ResultsOut of 242 T1D patients interviewed, 114 (47.1%) had self-reported hypoglycemia. The most reported symptom of hypoglycemia was sweating (91.7%), followed by dizziness and hunger and nausea with a prevalence of 24.8 and 14.5%, respectively. The study also found that educational level with reading and writing skills up to primary level [adjusted odds ratio, AOR = 0.41; 95% confidence interval, CI (0.19–0.88)] and secondary level and above [AOR = 0.32, 95% CI (0.14–0.70)], poor knowledge of diabetes [AOR = 2.26, 95% CI (1.06–4.84)], good knowledge of insulin self-administration [AOR = 0.54, 95% CI (0.30–0.99)], and duration of insulin use ≥5 years [AOR = 3.93, 95% CI (1.44–10.7)] were factors associated with hypoglycemia.ConclusionsThe prevalence of hypoglycemia was found remarkable. We can conclude that hypoglycemia is of public health importance among T1D patients. Since the study assesses hypoglycemia after insulin injection, this prevalence may be due to the poor practice of insulin injection. Therefore, imparting education on the proper technique of insulin administration should be considered at each follow-up visit.
Cost-Utility of Acromegaly Pharmacological Treatments in a French Context
Authors: Brue Thierry , Chanson Philippe , Rodien Patrice , Delemer Brigitte , Drui Delphine , Marié Lucile , Juban Laurène , Salvi Lara , Henocque Robin , Raverot Gérald 
Published: October 2021

ObjectiveEfficacy of pharmacological treatments for acromegaly has been assessed in many clinical or real-world studies but no study was interested in economics evaluation of these treatments in France. Therefore, the objective of this study was to estimate the cost-utility of second-line pharmacological treatments in acromegaly patients.MethodsA Markov model was developed to follow a cohort of 1,000 patients for a lifetime horizon. First-generation somatostatin analogues (FGSA), pegvisomant, pasireotide and pegvisomant combined with FGSA (off label) were compared. Efficacy was defined as the normalization of insulin-like growth factor-1 (IGF-1) concentration and was obtained from pivotal trials and adjusted by a network meta-analysis. Costs data were obtained from French databases and literature. Utilities from the literature were used to estimate quality-adjusted life year (QALY).ResultsThe incremental cost-utility ratios (ICUR) of treatments compared to FGSA were estimated to be 562,463 € per QALY gained for pasireotide, 171,332 € per QALY gained for pegvisomant, and 186,242 € per QALY gained for pegvisomant + FGSA. Pasireotide seems to be the least cost-efficient treatment. Sensitivity analyses showed the robustness of the results.ConclusionFGSA, pegvisomant and pegvisomant + FGSA were on the cost-effective frontier, therefore, depending on the willingness-to-pay for an additional QALY, they are the most cost-effective treatments. This medico-economic analysis highlighted the consistency of the efficiency results with the efficacy results assessed in the pivotal trials. However, most recent treatment guidelines recommend an individualized treatment strategy based on the patient and disease profile.
Prediction and Identification of Power Performance Using Polygenic Models of Three Single-Nucleotide Polymorphisms in Chinese Elite Athletes
Authors: Yang Ruoyu , Jin Feng , Wang Liyan , Shen Xunzhang , Guo Qi , Song Haihan , Hu Jingyun , Zhao Qiang , Wan Jian , Cai Ming 
Published: October 2021

Objective: The manuscript aims to explore the relationship between power performance and SNPs of Chinese elite athletes and to create polygenic models.Methods: One hundred three Chinese elite athletes were divided into the power group (n = 60) and endurance group (n = 43) by their sports event. Best standing long jump (SLJ) and standing vertical jump (SVJ) were collected. Twenty SNPs were genotyped by SNaPshot. Genotype distribution and allele frequency were compared between groups. Additional genotype data of 125 Chinese elite athletes were used to verify the screened SNPs. Predictive and identifying models were established by multivariate logistic regression analysis.Results: ACTN3 (rs1815739), ADRB3 (rs4994), CNTFR (rs2070802), and PPARGC1A (rs8192678) were significantly different in genotype distribution or allele frequency between groups (p &lt; 0.05). The predictive model consisted of ACTN3 (rs1815739), ADRB3 (rs4994), and PPARGC1A (rs8192678), the area under curve (AUC) of which was 0.736. The identifying model consisted of body mass index (BMI), standing vertical jump (SVJ), ACTN3, ADRB3, and PPARGC1A, the area under curve (AUC) of which was 0.854. Based on the two models, nomograms were created to visualize the results.Conclusion: Two models can be used for talent identification in Chinese athletes, among which the predictive model can be used in adolescent athletes to predict development potential of power performance and the identifying one can be used in elite athletes to evaluate power athletic status. These can be applied quickly and visually by using nomograms. When the score is more than the 130 or 148 cutoff, it suggests that the athlete has a good development potential or a high level for power performance.
Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis
Authors: Delemarre Eveline M. , van Hoorn Laura , Bossink Aik W. J. , Drylewicz Julia , Joosten Simone A. , Ottenhoff Tom H. M. , Akkerman Onno W. , Goletti Delia , Petruccioli Elisa , Navarra Assunta , van den Broek Brigitte T. A. , Paardekooper Sanne P. A. , van Haeften Ineke , Koenderman Leo , Lammers Jan-Willem J. , Thijsen Steven F. T. , Hofland Regina W. , Nierkens Stefan 
Published: October 2021

IntroductionThere is an urgent medical need to differentiate active tuberculosis (ATB) from latent tuberculosis infection (LTBI) and prevent undertreatment and overtreatment. The aim of this study was to identify biomarker profiles that may support the differentiation between ATB and LTBI and to validate these signatures.Materials and MethodsThe discovery cohort included adult individuals classified in four groups: ATB (n = 20), LTBI without prophylaxis (untreated LTBI; n = 20), LTBI after completion of prophylaxis (treated LTBI; n = 20), and healthy controls (HC; n = 20). Their sera were analyzed for 40 cytokines/chemokines and activity of adenosine deaminase (ADA) isozymes. A prediction model was designed to differentiate ATB from untreated LTBI using sparse partial least squares (sPLS) and logistic regression analyses. Serum samples of two independent cohorts (national and international) were used for validation.ResultssPLS regression analyses identified C-C motif chemokine ligand 1 (CCL1), C-reactive protein (CRP), C-X-C motif chemokine ligand 10 (CXCL10), and vascular endothelial growth factor (VEGF) as the most discriminating biomarkers. These markers and ADA(2) activity were significantly increased in ATB compared to untreated LTBI (p ≤ 0.007). Combining CCL1, CXCL10, VEGF, and ADA2 activity yielded a sensitivity and specificity of 95% and 90%, respectively, in differentiating ATB from untreated LTBI. These findings were confirmed in the validation cohort including remotely acquired untreated LTBI participants.ConclusionThe biomarker signature of CCL1, CXCL10, VEGF, and ADA2 activity provides a promising tool for differentiating patients with ATB from non-treated LTBI individuals.
Functionally Mature CD1c+ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium
Authors: Canavan Mary , Marzaioli Viviana , Bhargava Vipul , Nagpal Sunil , Gallagher Phil , Hurson Conor , Mullan Ronan , Veale Douglas J. , Fearon Ursula 
Published: October 2021

ObjectiveTo examine the role of synovial CD1c+DCs in patients with Inflammatory Arthritis (IA) with a specific focus on the transcriptional and maturation signatures that govern their function.MethodsRNA sequencing was performed on healthy control (HC) peripheral blood (PB), IA PB, and IA synovial fluid (SF) CD1c+DCs. Multiparametric flow-cytometry and SPICE analysis were used to examine site [SF and Synovial Tissue (ST) CD1c+DCs] and disease specific characteristics of CD1c+DCs, while functional assays such as antigen processing, activation, and MMP production were also performed.ResultsIncreased frequency of CD1c+DCs (p&lt;0.01) with a concomitant increase in CD80, CCR7 (p&lt;0.01), and CXCR3 (p&lt;0.05) expression was identified in IA PB compared to HC PB. Enrichment of CD1c+DCs was identified in IA synovial tissue (ST) (p&lt;0.01) and IA SF (p&lt;0.0001) compared to IA PB, while RNAseq revealed distinct transcriptional variation between PB and SF CD1c+DCs. Flow cytometry revealed increased expression of CD83, CD80, PD-L1, and BTLA (all p&lt;0.05) in IA SF CD1c+DCs compared to PB, while SPICE identified synovial cells with unique co-expression patterns, expressing multiple DC maturation markers simultaneously. Functionally, synovial CD1c+DCs are hyper-responsive to TLR7/8 ligation (p&lt;0.05), have decreased antigen processing capacity (p=0.07), and display dysregulated production of MMPs. Finally, examination of both synovial CD1c+DCs and synovial CD141+DCs revealed distinct maturation and transcriptomic profiles.ConclusionSynovial CD1c+DCs accumulate in the inflamed IA synovium in a variety of distinct poly-maturational states, distinguishing them transcriptionally and functionally from CD1c+DCs in the periphery and synovial CD141+DCs.