bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the intestinal microbiome in colorectal cancer
Authors: Gataullin B I , Gataullin I G , Nga Nguyen Thi , Kolpakov A I , Ilinskaya O N 
Published: April 2021

Aim. To conduct a comparative analysis of the microbiome of biopsies of a tumor and normal intestinal epithelium of patients diagnosed with colorectal cancer and to identify of functional activities of the obtained bacterial isolates that affect the development of the tumor.
Methods. The study included 50 patients with malignant neoplasms of the colon: 36 men and 24 women. The mean age of the patients was 64.110.2 years. To analyze the microbiota of the biopsies, DNA samples were obtained from the tissue of the unaffected colon mucosa and tumor of the patients. Bacterial 16S rRNA genes fragments were amplified using bar-coded primer bakt_341f. Metagenomic next-generation sequencing was performed using the MiSeq platform (Illumina, USA). The obtained data were processed by bioinformatic methods using the QIIME package. Recognition of microorganisms depending on the morphotype and gram staining of the microflora was carried out using combination differential media and biochemical tests. Statistical analysis was carried out using Microsoft Excel, Service Pack 2 for Office XP, Statistica 6.0 (StatSoft). A comparative analysis was performed with the Student's t-test and the MannWhitney test in case of unmet conditions of validity. Alpha diversity of bacterial communities was quantified by the Shannon diversity index and the UniFrac distance for beta diversity analysis.
Results. In patients with colorectal cancer, 5 bacterial phyla were isolated, the predominant of which were Firmicutes and Bacteroidetes, while the content of Actinobacteria was low. In addition, a higher number of representatives of Fusobacteria was observed in the tumor tissue compared to the tissue of a healthy mucosa, at a distance of 5 centimeters proximal to the tumor. The results of this study indicate that the microbiome of a tumor and a healthy mucosa fundamentally differ from each other not only in morphotype and gram staining but also in antagonistic, hemolytic and ribonucleolytic activities.
Conclusion. Colonization of the tumor by dominant aggressive Gram-negative bacteria leads to significant changes in the tumor microbiome composition compared with normal mucosa, whose representatives are displaced from the damaged epithelium by more aggressive strains.
Features of the clinical course of nephrolithiasis in patients with hyperparathyroidism
Authors: Baranova I A , Zykova T A , Baranov A V 
Published: April 2021

Aim. To assess the incidence of kidney stone disease and to identify its clinical course in patients with primary hyperparathyroidism.
Methods. 48 medical records of patients hospitalized with primary hyperparathyroidism were retrospectively analyzed. The average age of the patients was 57 [53; 61] years. The medical history, complaints upon admission, the clinical presentation, the results of laboratory test and instrumental examination were studied in evaluating the medical records. The patients were divided into the group with nephrolithiasis (n=33) and the group without nephrolithiasis (n=15). The differences between the two groups were tested for statistical significance by the MannWhitney U test.
Results. Among patients with primary hyperparathyroidism, nephrolithiasis was detected in 69% of patients, of which 90% were women in the postmenopausal period. The course of the kidney stone disease in these patients was characterized by frequent recurrence with a predominance of bilateral renal impairment (62%). The duration of nephrolithiasis before the diagnosis of primary hyperparathyroidism was 6 [1; 19] years, and this complication was often the first manifestation of the disease. According to the instrumental examination of kidney in patients with nephrolithiasis, small stones up to 5 mm in diameter were detected in 42% of cases, asymptomatic kidney stones in 15% of cases. A severe complication of primary hyperparathyroidism staghorn calculi were found in 2 (10%) patients. The patients in the group with nephrolithiasis showed higher serum calcium (p=0.022) and parathyroid hormone (p=0.007) levels compared with patients in the group without nephrolithiasis.
Conclusion. Nephrolithiasis is a common complication of primary hyperparathyroidism; the presence of nephrolithiasis is associated with more significant changes in calcium and phosphate metabolism and is also characterized by a frequent asymptomatic course, thus requiring attention of specialists to this type of complications in primary hyperparathyroidism.
Stimulasi Aspek Perkembangan Anak Melalui APE Bermuatan Kearifan Lokal di PAUD Madura
Authors: Arianto Fajar Lukman Tri , Yuniar Dias Putri 
Published: April 2021

Masa golden age pada anak usia dini perlu distimulasi dengan beragam media yang ada untuk membantu enam aspek perkembangan anak secara optimal. Disisi lain, kemajuan zaman dan teknologi perlu diimbangi dengan penngenalan budaya agar tidak tergerus. Media pembelajaran berkearifan lokal yang berupa puzzle, serbuk jagung warna-warni dan kotak pintar digunakan sebagai Alat Permainan Edukatif (APE) yang diproses dari limbah jonggol jagung. Alat permainan edukatif berupa puzzle, serbuk jagung warna-warni dan kotak pintar digunakan pada anak usia dini saat belajar di sekolah (luring) pada lima lembaga PAUD yang ada di Bangkalan Madura. Penggunaan alat permaina edukatif digunakan untuk menstimulasi Enam aspek perkembangan meliputi nilai agama moral, sosial emosional, bahasa, kognitif, motorik, dan seni agar dapat terstimulasi dengan baik melalui media hasil limbah jonggol jagung. Jenis penelitian ini menggunakan pendekatan deskriptif kualitatif dengan teknik pengumpulan data melalui studi observasi, wawancara dan dokumentasi kemudian dianalisis dengan cara pengelompokan hasil, deskripsi atau menganalisis data, penyajian dan pengambilan kesimpulan. Hasil dari kegiatan penelitian ini didapatkan tiga macam jenis media pembelajaran yang efektif yang dapat menstimulasi enam aspek perkembangan pada anak usia dini dengan melihat tanggapan yang diambil ke ibu guru di lima Lembaga PAUD kota Bangkalan melalui G-form yaitu prosentase serbuk jagung warna-warni (sergunani) 78, 6%, kotak pintar 66, 7%, dan puzzle 78, 6%
Equipping Adult Learners with Basic Literacy Skills for Cognitive Sustainability in Lagos State, Nigeria
Authors: Anyikwa Blessing , Yinusa Oyekunle Oyekunle 
Published: April 2021

Abstract The non-literate adult citizens in Nigeria are often faced with the inability to apply mental intelligence in their lifestyles which is reducing their worth and relevance in the 21st century literate society. The study therefore, seeks to equip adult learners with basic literacy skills for cognitive sustainability in Lagos state, Nigeria. Four research questions were raised and answered; and four hypotheses were tested to guide the study. The study adopted descriptive survey research design. The instruments adopted for the study were Key Informant Interview (KII) and a Questionnaire. A 20-item questionnaire titled “Adult Learners’ Basic Literacy Skills Questionnaire”, (ALBLSQ) was developed by the researchers. The instrument was validated using content and face validity according to the standard approved by the National Mass Education Commission in Nigeria, and the State Agency for Mass Education in Lagos State, Nigeria (NMEC/NOGALSS). A total of one hundred and eighty (180) questionnaires were administered purposively to adult learners across the six NMEC/NOGALSS literacy centers in Lagos state, and one hundred and forty-five (145) were retrieved. The reliability of the instrument was confirmed using a test-retest procedure, which gave a correlation coefficient of 0.87. The data was presented using frequency distribution tables, percentages, and Bar Charts. The data was analyzed using Spearman Rank Order Correlation Coefficient and T-test statistical tools to test the hypotheses at 0.05 significance level. The study revealed that a significant difference exists between the performance of adult learners before intervention and the performance of adult learners after intervention of the adult basic literacy programme amongst others. The study concluded and recommended that the curriculum of the adult basic literacy should be designed to have a combination of English and mother tongue language as a medium of instruction in order to aid cognitive development among adult learners, inter alia.
Algunas consideraciones lingüisticas para el estudio del desarrollo histórico del sujeto del yo
Authors: González Carlos Gustavo 
Published: April 2021

Como inicio a una contribución al desarrollo psicológico-histórico del sujeto, es analizadoel yo como agente. Utilizando métodos de lingüística comparativa y de antropologíalingüística fueron identificados elementos sintácticos que pueden utilizarse como indicadores del desarrollo del yo.Fundamentalmente, se analizan las alteraciones en las voces verbales pasivas, mediay activa, porque implican cambios en el modo de actuar del yo. Volviendo brevementeal análisis de Dodds, se presentan después ejemplos similares de cambios en el uso de las voces verbales en latín y en inglés. Intentando re-interpretar estos cambios de la agencia del yo en el aparato psíquico, se propone el concepto de “coagentes del yo”.
Las sombras de la energía solar fotovoltaica
Authors: Lamas Diego Germán 
Published: April 2021

Vivimos en una época en la que se demonizan las fuentes de “energías convencionales” debido a los efectos negativos que las misma tienen sobre el “medioambiente” o los accidentes sufridos en su explotación,y abrazamos sin ningún tipo de prejuicio y rápidamente las “energías renovables” sin hacernos muchas preguntas. La búsqueda de soluciones o alternativas rápidas y socialmente aceptables a los problemas expuestos, nos llevan a no exigir traer a la superficie aquellas cosas no tan buenas que pueden tener las nuevas tecnologías, que tienen un gran abanico de puntos positivos frente a sus competidoras convencionales; y que deben desarrollarse sin ocultar o esconder sus puntos negativos. En este trabajo se ponen en evidencia esas debilidades que presenta la energía solar fotovoltaica para que desde la visión mpliada nos permita exigir, interesados e involucrados en el futuro, que se profundicen los análisis en este tipo de tecnología y sus proyectos; para no vernos sorprendido por un impacto negativo que hoy sabemos o intuimos puede tener.
ФАКТОРИ ПОПИТУ НА БАНКІВСЬКІ КРЕДИТИ В УКРАЇНІ: МОДЕЛЮВАННЯ ТА ОЦІНКА
Authors: Глущенко С. , Шпортюк В. 
Published: April 2021

Анотація. Наведено результати моделювання та оцінки ефектів впливу чинників попиту на банківські кредити з боку юридичних і фізичних осіб на обсяги банківського кредитування в Україні. Узагальнено чинники впливу на обсяги банківського кредитування з боку попиту від юридичних і фізичних осіб, виконано моделювання на базі статистичних даних для української практики в період з 2006 року до 2020-го. Розроблено векторно-авторегресійну модель оцінки чинників впливу на попит на банківські кредити з боку суб’єктів господарювання. Відповідно до побудованої моделі зроблені висновки, що зміна попиту на кредитні ресурси з боку юридичних осіб пояснюється зміною процентної ставки (на 30%), зміною індексу промислової продукції (15,6%), зміною індексу ПФТС (10,7%), зміною індексу цін виробників промислової продукції (1,0%), зміною самих себе у часі (42,5%). Також розроблено векторно-авторегресійну модель оцінки чинників впливу на попит на банківські кредити з боку домашніх господарств. Відповідно до побудованої моделі зроблено висновки, що зміна попиту на кредитні ресурси з боку фізичних осіб пояснюється зміною обсягу середньої заробітної плати (16,2 %), зміною процентної ставки (16 %), зміною витрат (8,2 %), зміною ВВП (7,7 %), індексом споживчих цін (6,9 %), зміною кількості зареєстрованих безробітних (2,9 %) і зміною самих себе в часі (42,1 %). Отримані результати можуть мати практичне застосування як у межах формування банківської кредитної політики, так і в межах державних регуляторних заходів впливу на активізацію кредитного сектору в країні.
Ключові слова: банківський кредит, чинники попиту на банківські кредити, VAR-моделювання, домогосподарства, суб’єкти господарювання.
Формул: 0; рис.: 3; табл.: 6; бібл. 11.
FINANCIAL CONTROL IN THE SYSTEM OF BUDGETARY SECURITY OF THE STATE AND REGIONS UNDER DECENTRALIZATION CONDITIONS IN UKRAINE
Authors: Kosova Т. , Voronkova О. , Kliuchka О. , Kostynets Іu. 
Published: April 2021

Abstract. The relevance of the topic of the study is determined by the processes of reforming financial control system under conditions of the budgetary decentralization and euro integration processes in Ukraine. The theoretical and methodological principles of researching budgetary security and decentralization were determined. Based on the data within a twenty-five-year period the dynamics of profits, costs and surplus of the Consolidated budget of Ukraine were analyzed. The influence of the economic development cyclicity on budgetary security in the part of occurrence of budgetary deficit was identified. The quantitative assessment of budget decentralization in Ukraine was made based on the share of revenue of local budget in the revenues of Consolidated budget as well as transfers in the revenue and expenditure of the State budget of Ukraine.
The scientific outcome of the study is the refinement of the definition of budget security for the state and the regions and substantiation of the conceptual model of financial control under decentralization conditions.
Unlike the existing definitions the proposed definition is grounded on the change of the ideology of the budget process participants under conditions of its democratization and decentralization as well as the risk-oriented and strategic approach.
The proposed conceptual model of financial control under decentralization conditions is grounded on the unified network of the state and municipal control authorities, delegation of control functions according to the budget powers, transition from the inspection of inter-budgetary transfers to the audit of budget security under conditions of accepted socio-economic living standards of the local population, unification and standardization of the approaches to conducting audits of legality and effectiveness of the formation and using the local budgets.
Keywords: financial, control, budgetary, system, security, state, regions, decentralization.
JEL Classifications E44, E60, E62, E69, H60, H61, H72, G28, R50, R58
Formulas: 0; fig.: 3; tabl.: 0; bibl.: 22.
FINANCIAL AND ECONOMIC ASPECTS OF PROFESSIONAL FOOTBALL INDUSTRY: TRENDS ANALYSIS AND DEVELOPMENT PROSPECTS
Authors: Reikin V. 
Published: April 2021

Abstract. The purpose of the study is the analysis of financial and economic aspects and assessment of current trends and prospects for the development of professional football industry as an independent academic field.
In this article the following general scientific and applied methods were used: analysis and comparison — to determine the main trends in the development of top professional football clubs in the context of globalization; generalization — to establish the influence of institutional factors on the economic results of football clubs activity; expert assessments — to determine the market value of players in the global transfer market; abstract and logical methods — for theoretical generalization of the obtained results, forecasting the prospects for the development of European professional football and formulating conclusions of the study.
The article deals with the analysis of financial and economic results of European football top clubs functioning in the pre-crisis period (before COVID-19). The author emphasizes the dualistic origins of modern professional football, which combines sports and commercial components. It is analyzed the impact of «Bosman case» and the rules of «financial fair play» on the professional football industry development in the context of globalization. The sources and structure of football top clubs income are also analyzed. The main focus is on European football, where current trends are most clearly manifested. The source of information was the annual reports of audit firms, specialized analytical laboratories and FIFA data.
As a result of globalization processes, the author predicts the creation of full-fledged «SuperLeague» championship of top clubs with the greatest financial opportunities, as well as the appearence of polycentrism phenomenon in the world football industry. The forecast scenarios of football industry perspectives, formulated by the author, to substantiate the financial and economic aspects of clubs and players transfer market functioning, can be used in practice to assess the potential and formulate strategies for professional football leagues and clubs.
Кeywords: «financial fair play», football industry, transfers, capitalization, investments, «Bosman case».
Formulas: 0; fig.: 6; tabl.: 0; bibl.: 29.
La trama en el espacio tridimensional. La aplicación de un recurso gráfico complementario en el nuevo edificio de la Fondation Louis Vuitton
Authors: Spina María Laura 
Published: April 2021

En el diseño de un Sistema de Identidad Visual de Alta Complejidad, el uso y aplicación de un repertorio de identificadores secundarios otorga valor a la identidad misma.
La aplicación de tramas bidimensionales aplicadas a espacios tridimensionales impacta eficazmente en la identidad de la empresa, resignificando el propio Sistema Visual convirtiendo al espacio arquitectónico en un hito señalético corporativo dentro del Programa Tridimensional.
Actualmente, marcas de Indumentaria reconocidas, recurren al dominio del espacio bitridimensional con el objetivo de convertirse en símbolos gráficos universales de alto poder de recordación dentro de un espacio urbano.
El Capital Intelectual y su Incidencia en la ProducciÃ³n de las Empresas Productoras de Banano en la Costa sur del Ecuador
Authors: Jaya Pineda Iddar IvÃ¡n , Plaza GuzmÃ¡n Jorge Javier , Novillo Maldonado Ernesto 
Published: April 2021

El presente trabajo de investigaciÃ³n se lo realizÃ³ por el entorno extremadamente competitivo en el Ã¡rea agrÃ­cola exigiendo a las empresas productoras de banano un esfuerzo constante en la mejora de sus procesos de producciÃ³n, comercializaciÃ³n, gestiÃ³n y direcciÃ³n econÃ³mica con un capital de talento humano calificado en el Ã¡rea de siembra y administraciÃ³n de las fincas. De esta manera los pequeÃ±os productores de banano tradicional se han visto obligados a depender cada vez mÃ¡s de la informaciÃ³n tÃ©cnica en el Ã¡rea agrÃ­cola, administrativa financiera proporcionada por un capital intelectual humano de alto nivel que toma como base objetiva ejercer una funciÃ³n vital: la toma de decisiones, donde se aprecia que las agrÃ­colas de economÃ­a familiar carecen de un capital intelectual idÃ³neo para ejercer esta funciÃ³n, a diferencia de las fincas asociadas que su visiÃ³n estÃ¡ orientando para insertarse y permanecer en el mercado bananero con productos de calidad, con volÃºmenes y periodicidad demandada, que permitan el desarrollo sostenible de la organizaciÃ³n, en el mercado interno como internacional, dando prioridad en los estÃ¡ndar de calidad en la fruta de exportaciÃ³n.

This paper was carried out due to the extremely competitive environment in the agricultural area. This requires the banana-producing companies to make a constant effort to improve their production, marketing, management, and economic management processes with a capital of qualified human talent in the area of sowing and administration of the farms. Through this way, small traditional banana producers have been forced to rely more and more on technical information in the agricultural, administrative, and financial area provided by a high-level human intellectual capital. This gave rise to the objective of performing a vital function, which is decision-making. Here, it can be seen that family farmers lack the ideal intellectual capital to exercise this function. This is unlike the associated farms where their vision is guiding to insert and remain in the banana market with quality products, with volumes and demanded periodicity. This has also led to the sustainable development of the organization, in the domestic and international markets, by giving priority to quality standards in export fruit.
ANALYSIS OF THE ORNAMENTAL FISH EXPORTS FROM THE AMAZON STATE, BRAZIL
Authors: TRIBUZY-NETO Ivan Azevedo , BELTRÃO Hélio , BENZAKEN Zehev Schwartz , YAMAMOTO Kedma Cristine 
Published: April 2021

The updated status of the ornamental fish trade from the Amazonas state was analyzed between the years of 2006-2015 (IBAMA database). The trade of ornamental fish from Amazonas state mainly consists of species extracted from nature. A total of 142,552,253 specimens were exported during the studied period. Sales plummeted since 2006, from 26,075,241 specimens exported then to 2,729,846 specimens in 2015 (Jan-Jul). Between 2006 and 2015, a total of US$ 23.0 million in revenue was generated from fish exports destined to 35 countries. Germany, Taiwan, USA and Japan accounted for 75.5% of the volume and 76.7% of the value exported. During this time, 375 species were exported, included Paracheirodon axelrodi, P. simulans, Hemigrammus bleheri, Otociclus affinis and O. hoppei that together represented 84.5% of exports. Thirty are not on the list of IBAMA species released for export, and six are currently on the list of endangered fauna of Brazil, being them: Hopliancistrus tricornis, Leporacanthicus joselimai, Parancistrus nudiventris, Peckoltia compta, Scobinancistrus auratus and S. pariolispos. These results are an additional tool for managers, environmentalists and decision makers to establish regulations to govern the trade.
Institutional Literacy and Libraries: Addressing Library Anxiety with a Personal Librarian Program
Authors: Doerksen Brad 
Published: April 2021

This article considers institutional literacy as a lens through which to consider causes of library anxiety and the development of library programs. Institutional literacy is the ability to read and engage with the ways of being and doing that are -- often invisibly -- embedded into institutions of all kinds. This article posits that the ability of library users to confidently engage with library services is in part predicated on the level of institutional literacy these users have, both in the institution of the library itself and any larger host institution – such as a university.
A setting such as a university requires a range of literacies, and those developing programs and services in such settings should not assume new and potential library users already have developed these literacies. While librarians are accustomed to considering information literacy as their contribution to this matrix, unfamiliar institutional literacy practices can present obstacles to new library users becoming information literate.
A comparison of research on the effects of a lack of institutional literacy and research into library anxiety demonstrates parallels that suggest that low levels of institutional literacy are a contributing factor to library anxiety, creating one of the aforementioned obstacles. Acting as institutional literacy mediators is one way library workers can respond to this challenge. The article concludes with a description of how the theoretical lens thus developed was used to inform the development of a personal librarian program at the University of Regina, in part by positioning librarians as institutional literacy mediators.