bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORPHOMETRIC CHANGES IN THE VENOUS VESSELS OF THE HEART VENTRICLES OF EXPERIMENTAL ANIMALS AT THE CONDITIONS OF COBALT CHLORIDE INTOXICATION
Authors: Hnatjuk М.S. , Cholach S. Ju. , Tatarchuk L. V. , Stets N. Ja. , Yasinovskyi O. B. 
Published: January 2025

Cobalt is a heavy metal that can damage organs and systems.It and its compounds are used in various branches of production and it often gets into the environment.
The aim. To morphometrically investigate the age-related features of the structural rearrangement of the venous vessels of the heart ventricles of experimental animals with cobalt poisoning.
Materials and methods. The venous vessels of the left and right ventricles of four groups of rats were morphometrically investigated. The first group – 30 six-month-old control animals, the 2 – 30 24-month-old rats, the – 30 six-month-old animals injected with cobalt chloride, the 4 – 30 24-month-old rats with cobalt chloride intoxication. This chemical agent was injected into the stomach at a daily dose of 0.004 g/kg for a month. Animals were euthanized by bloodletting under thiopental-sodium anesthesia. Histological micropreparations were made from the left and right ventricles. The parameters of the veins of the left and right ventricles were determined morphometrically on micropreparations. Statistical processing of quantitative indicators was carried out.
Results. Morphometrically, it was found that the intoxication of experimental animals with cobalt chloride leads to a marked expansion of the venous vessels of the left and right ventricles, thinning of their walls, a decrease in the area of ​​endothelial cells and their nuclei, a violation of nuclear-cytoplasmic relations in endotheliocytes, and an increase in the relative volumes of affected endotheliocytes.
Conclusions. With a monthly intragastric administration of cobalt chloride to white male rats, a pronounced structural rearrangement of the venous vessels of the left and right ventricles of the heart occurs, which is characterized by their expansion, thinning of the wall, an increase in the venous index, a violation of venous drainage from the studied heart chambers, venous congestion, damage to endothelial cells , their dysfunction, violation of blood flow and trophic supply of myocardial structures, their dystrophic, necrobiotic changes, foci of infiltrates and sclerosis. The established morphological changes prevailed in the studied left ventricle of 24-month-old experimental animals.
Comparative characteristics of various methods of osteosynthesis in wounded subjects with gunshot lesions of long bones
Authors: Tanasiienko P.V. , Vasylov V.V. 
Published: January 2025

Background. In the structure of combat injuries, gunshot wounds of the limbs prevail, which make up 50–80 % of all wounds, of which 57.3 % have multiple injuries of the limbs. At least one-quarter of all combat injuries involve the lower extremities. The purpose was to compare and choose the optimal osteosynthesis system to improve the provision of medical care to wounded people with gunshot injuries of long bones. Materials and methods. To fulfill the objectives of our study, we analyzed 174 cases of long bone injuries received as a result of modern warfare during the full-scale invasion of russia in the period from 2022 to 2024. Two comparison groups were formed in the study. The first group included 93 patients who underwent consecutive osteosynthesis, which accounted for 53.4 % of the total array. The second group included 81 patients with one-stage transosseous external osteosynthesis, which accounted for 46.6 % of the total array. Results. Among patients with conversion osteosynthesis, the complete union was observed in 73.1 %, which is 11.5 % more than when using one-moment osteosynthesis. Among the wounded with conversion osteosynthesis, delayed consolidation of fractures was observed in 11.8 %, while this indicator was 17.3 % when single-moment osteosynthesis was used. In patients with conversion osteosynthesis, osteomyelitis was detected less often, observed in 25.8 % of cases. Wound suppuration and implant instability were detected in 14.5 % of patients. Conclusions. The use of the technique of two-stage conversion osteosynthesis in injured patients with isolated gunshot fractures of the long bones of the limbs ensures better anatomical and functional results in comparison with the technique of transosseous one-moment osteosynthesis. When using the conversion method of osteosynthesis, the number of infectious postoperative complications, particularly the development of osteomyelitis and wound suppuration, significantly decreased. The data of our study testify to the priority use of the conversion method of osteosynthesis in patients with gunshot wounds of long bones.
Comparative analysis of the effectiveness of caudal epidural blocks and combined pharmacological therapy in the treatment of patients with discogenic low back pain
Authors: Chervatiuk M.S. , Fishchenko І.V. 
Published: January 2025

Background. The most common cause of chronic nonspecific pain in the lumbar spine is discogenic pain syndrome — 42 % of cases. In the arsenal of modern medicine, among the safe methods of treating discogenic pain syndrome, two areas of treatment are traditionally distinguished — conservative and surgical. Epidural block (EB) occupies an intermediate position between surgical and conservative treatment me­thods, as it can be treated as a minimally invasive manipulation, as well as an active therapeutic agent. The purpose of the study was to conduct a compa­rative analysis of the effectiveness of trea­ting discogenic pain in the lumbar spine using epidural blockades through the hiatus sacralis and combined pharmacological therapy. Materials and methods. In the study, patients were divided into 2 groups: the EB group (epidural blockades) — 36 (59.1 %) patients, who were performed 1–2 EBs with a frequency of 1 week (19 women, 17 men); the FT group (pharmacological therapy) — 25 (40.9 %) patients, who received comprehensive conservative treatment for 14 days. The study was conducted in the spine surgery clinic of the State Institution “Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine” from September 2023 to October 2024. The results were assessed using the visual analog scale (VAS), Oswestry questionnaire. Results. Assessment of the functional state after treatment showed that at the time of the final survey, after 6 months, positive changes with the absence of functio­nal limitations were no­ted by 30 (83.3 %) patients with chronic nonspecific pain in the lumbar spine in the EB group and 8 (32 %) patients in the FT group. Conclusions. The use of EB allows for effective reduction of pain syndrome and improvement of the quality of life of patients with back pain almost immediately after the procedure (5–7 days) while maintaining effectiveness throughout the entire observation period (up to 6 months).
Analisis Spasial Rencana Tata Ruang Wilayah Berbasis Kerentanan Gempa Bumi (Studi Kasus: Kecamatan Cisarua Kabupaten Bandung Barat)
Authors: Pamungkas Totok Doyo , Firdaus Rival Akbar , Rohmah Nurul Aniyyatur , Rizki Recky , Affriani Asri Ria 
Published: January 2025

Kecamatan Cisarua merupakan salah satu wilayah yang dilewati oleh jalur Sesar Lembang sehingga rawan terhadap bencana gempabumi. Sesar Lembang terletak di utara Kota Bandung yang tergambar jelas dalam peta topografi sebagai gawir memanjang berorientasi barat-timur. Dalam sejarahnya, Sesar Lembang pernah menyebabkan gempabumi, salah satunya terjadi pada tanggal 28 Agustus 2011 yang menyebabkan sebanyak 268 rumah rusak. Saat ini Indonesia telah memiliki UU No. 24 tahun 2007 tentang Penanggulangan Bencana dan UU No. 26 tahun 2007 tentang Penataan Ruang. Pada tingkat kementerian terdapat Peraturan Menteri Pekerjaan Umum Nomor 21/PRT/M/2007 tentang Pedoman Penataan Ruang di Kawasan Rawan Letusan Gunung Berapi dan Kawasan Rawan Gempa Bumi. Berdasarkan hal tersebut, dibutuhkan sebuah evaluasi rencana tata ruang wilayah (RTRW) yang berlandaskan kerentanan terhadap bencana gempabumi. Penelitian ini menggunakan analisis overlay untuk mengetahui kesesuaian antara RTRW tahun 2009-2029 dan tutupan lahan eksisting tahun 2024 dengan zonasi tingkat kerentanan gempabumi berdasarkan Peraturan Menteri Pekerjaan Umum Nomor 21/PRT/M/2007 sehingga dapat diketahui kekurangan dan kelemahan pola ruang masa kini dan mendatang. Hasil penelitian menunjukkan bahwa tingkat kesesuaian antara tutupan lahan eksisting tahun 2024 dengan zonasi tingkat kerentanan terhadap bencana gempabumi memiliki kesesuaian sebesar 92%, artinya lebih dari 3/4 atau 4909 Ha wilayah Kecamatan Cisarua sesuai dengan peruntukannya berdasarkan zonasi tingkat kerentanan terhadap bencana gempabumi. Hal yang sama juga ditunjukkan pada tingkat kesesuaian antara RTRW 2009 – 2029 dengan zonasi tingkat kerentanan terhadap bencana gempabumi yang memiliki kesesuaian sebesar 92%, sementara 8% atau seluas 454 Ha tidak sesuai dengan peruntukannya.
Daily Activity and Honey Production Patterns of <i>Tetragonula laeviceps</i> Smith (Hymenoptera: Apidae) During the Wet and Dry Seasons
Authors: Suhri Andi Gita Maulidyah Indraswari , Retnoaji Bambang , Mustamin Yusdar , Kahono Sih 
Published: January 2025

Honey production by stingless bees is closely related to the foraging activities of worker bees, particularly nectar foraging. The urgency of this study stems from the community's need for adequate understanding and information on honey production which can vary due to various factors, such as forage and season. The purpose of this study was to determine the extent to which foraging activity affects the amount of honey produced by T. laeviceps during the rainy and dry seasons. The focal sampling method was used to observe foraging behaviour and the acetolysis method was used to observe pollen. The abiotic factors were measured through direct observation. Honey production was observed as a result of foraging behaviour and variations in abiotic factors. In SPSS v27 software, data from foraging behaviour observations were analysed using one-way ANOVA followed by Tukey's test with 95% confidence level and interpreted in tables and figures. Multiple linear regressions and Pearson’s correlations were used to test the relationship between abiotic variables and bee return to hive behaviour. All honey volume data were collected, averaged, and evaluated using bar charts. Based on these results, the amount of honey produced by T. laevicepsin the dry season was significantly higher than that produced during the wet season. This was because the number of bees actively foraging was also higher in the dry season (June-August) which was strongly influenced by temperature and light intensity (p > 0.05). In addition, the number of flowering plants available for harvest during the dry season was higher than that during the rainy season. The results of this study can be used as a reference by beekeepers to determine the appropriate time to harvest honey. Information on the types of forage plants identified in this study can provide information on bee preferences in making choices related to forage plants.
Matica: migrantes venezuelanos e redes migratórias em Boa Vista Roraima
Authors: Ângelo Germano Lopes , Cavalcante Olendina de Carvalho 
Published: January 2025

Migração é um fenômeno contemporâneo no Brasil. O mais acentuado é a dos venezuelanos que entram ao território brasileiro a partir da cidade de Pacaraima que faz fronteira com a Venezuela. Esta cidade está localizada no Estado de Roraima. A maioria teve como destino em um primeiro momento a capital deste Estado A migração é um fenômeno contemporâneo no Brasil, destacando-se especialmente a dos venezuelanos que entram no território brasileiro pela cidade de Pacaraima, na fronteira com a Venezuela. Esta cidade está localizada no Estado de Roraima, e a maioria dos migrantes tem como destino inicial a capital deste Estado. O presente artigo possui dois objetivos. Primeiramente, compreender a construção das redes migratórias em três espaços de sociabilidade dos migrantes venezuelanos. Em segundo lugar, analisar o papel dessas redes no processo migratório venezuelano em Boa Vista, Roraima. Para atingir esses objetivos, descrevemos a organização e a dinâmica de três espaços de sociabilidade chamados de maticas. Esses espaços estão localizados no perímetro urbano da capital do estado de Roraima. Os migrantes venezuelanos utilizam esses espaços para oferecer sua força de trabalho de maneira informal, uma vez que não têm interesse no trabalho formal, devido a estratégias de sobrevivência. Nossa metodologia incluiu pesquisa bibliográfica sobre a migração venezuelana e a realização de etnografia participante, na qual ouvimos as narrativas de três migrantes venezuelanos, os integrantes mais antigos de cada espaço. Seguindo a abordagem de Clifford Geertz (1989), buscamos interpretar em segunda ou terceira mão a cultura dos migrantes que interagem nesses espaços. As maticas funcionam como redes de acolhimento migratório tanto em âmbito nacional quanto internacional. Nesses espaços, são construídas redes pessoais, sociais e migratórias, permitindo que os migrantes enfrentem a exclusão a que são submetidos por meio da interiorização da Operação Acolhida, conforme relatado por nossos interlocutores.
Analisis Tingkat Kepuasan Pengunjung Terhadap Website Ancol.Com Menggunakan Metode Webqual 4.0
Authors: Rakhmah Syifa Nur , Nisa Khoirun 
Published: January 2025

Dengan menggunakan teknik pemasaran digital yang tepat, kita dapat menjangkau audiens yang lebih luas dan meningkatkan visibilitas brand secara online salah satunya pada destinasi wisata, meningkatkan jangkauan pemasaran, dan memudahkan wisatawan mengakses informasi mengenai objek wisata yang ingin dikunjunginya adalah melalui situs web. Ancol.com merupakan situs web resmi Taman Impian Jaya Ancol yang dapat digunakan untuk membeli dan mengiklankan tiket. Saat ini, kepuasan pengunjung menjadi salah satu faktor kunci penentu keberhasilan sebuah situs web. Akan tetapi, keberadaan situs web ini belum tentu menjamin tingkat kepuasan pengunjung secara optimal, karena diketahui bahwa untuk pembelian tiket wisata Ancol masih menggunakan platform pembelian tiket lainnya. Dengan demikian, untuk mengetahui sejauh mana situs web ancol.com telah memenuhi kebutuhan dan harapan pengunjung, maka dilakukan analisis tingkat kepuasan pengunjung terhadap situs web tersebut dengan menggunakan metodologi Webqual 4.0 berdasarkan tiga kriteria: user friendly, kualitas informasi, dan kualitas interaksi layanan. Hasil uji validitas penelitian menunjukkan setiap indikator pada kuesioner memiliki nilai r2 & r3, sehingga disimpulkan bahwa setiap indikator valid. Reliabilitas penelitian ini diukur melalui nilai alpha r sebesar 0,824, menunjukkan tingkat reliabilitas yang baik. Hasil analisis regresi berganda menunjukkan: H0 ditolak serta H1, H2, dan H3 diterima Dari hasil analisis, tampak bahwa nilai R Square adalah 0,469. Ini menunjukkan bahwa ada pengaruh bersama variabel X1 (Penggunaan) dan X2 (Kualitas interaksi) terhadap variabel Y (Kualitas Informasi) sebesar 46,9%. Hasil pembahasan penelitian memperlihatkan bahwa informasi kualitas, interaksi layanan, dan usability dapat memengaruhi kepuasan pengguna terhadap website Ancol.com.
Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year
Authors: Barovic Marko , Hahn Joke Johanna , Heinrich Annett , Adhikari Trishla , Schwarz Peter , Mirtschink Peter , Funk Alexander , Kabisch Stefan , Pfeiffer Andreas F.H. , Blüher Matthias , Seissler Jochen , Stefan Norbert , Wagner Robert , Fritsche Andreas , Jumpertz von Schwartzenberg Reiner , Chlamydas Sarantis , Harb Hani , Mantzoros Christos S. , Chavakis Triantafyllos , Schürmann Annette , Birkenfeld Andreas L. , Roden Michael , Solimena Michele , Bornstein Stefan R. , Perakakis Nikolaos 
Published: January 2025

OBJECTIVE
Progression of prediabetes to type 2 diabetes has been associated with β-cell dysfunction, whereas its remission to normoglycemia has been related to improvement of insulin sensitivity. To understand the mechanisms and identify potential biomarkers related to prediabetes trajectories, we compared the proteomics and metabolomics profile of people with prediabetes progressing to diabetes or reversing to normoglycemia within 1 year.

RESEARCH DESIGN AND METHODS
The fasting plasma concentrations of 1,389 proteins and the fasting, 30-min, and 120-min post–oral glucose tolerance test (OGTT) plasma concentrations of 152 metabolites were measured in up to 134 individuals with new-onset diabetes, prediabetes, or normal glucose tolerance. For 108 participants, the analysis was repeated with samples from 1 year before, when all had prediabetes.

RESULTS
The plasma concentrations of 14 proteins were higher in diabetes compared with normoglycemia in a population with prediabetes 1 year before, and they correlated with indices of insulin sensitivity. Higher levels of dicarbonyl/L-xylulose reductase and glutathione S-transferase A3 in the prediabetic state were associated with an increased risk of diabetes 1 year later. Pathway analysis pointed toward differences in immune response between diabetes and normoglycemia that were already recognizable in the prediabetic state 1 year prior at baseline. The area under the curve during OGTT of the concentrations of IDL particles, IDL apolipoprotein B, and IDL cholesterol was higher in new-onset diabetes compared with normoglycemia. The concentration of glutamate increased in prediabetes progressing to diabetes.

CONCLUSIONS
We identify new candidates associated with the progression of prediabetes to diabetes or its remission to normoglycemia. Pathways regulating the immune response are related to prediabetes trajectories.
Möte mellan tradition och förändring: en forskningsöversikt om undervisning i fritidshem
Authors: Elvstrand Helene , Boström Lena , Orwehag Monica 
Published: January 2025

I fritidshemmet har under det senaste decenniet en förskjutning skett från en socialpedagogisk tradition till en ökad betoning på lärande och undervisning. Fenomenet undervisning är tämligen nytt i fritidshem och flera studier visar att fritidshemslärare upplever en osäkerhet i hur detta ska tolkas och omsättas i praktiken. I denna forskningsöversikt ligger fokus på undervisning och hur det är belyst i relation till svensk fritidshemspraktik. Syftet med studien är att beskriva vad som karaktäriserar undervisning i fritidshem i svensk forskning under tjugo år. Metoden är en systematisk forskningsöversikt (Systematic Literature Review, SLR) med en kvantitativ innehållsanalys och en kvalitativ tematisk analys. Den tematiska analysen genererade tre innehållsliga teman: undervisningsområden, förutsättningar för undervisning, och aktörsperspektiv på undervisning. Resultatet visar att ett intresse för undervisning som fenomen har vuxit fram de senaste åren men att det finns få studier som på ett explicit sätt berör detta. I stället behandlar en majoritet av studierna undervisning implicit och berör områden som kan ses vara relaterade till fritidshemmets undervisning. Studien visar på vikten av att mer forskning, utifrån olika perspektiv och ansatser, genomförs i relation till undervisning i fritidshem.
ENGLISH ABSTRACT
Traditions and Change: A Review Article on Swedish School-age Educare Practice
Over the last decade, there has been a shift in the Swedish school-age educare (SAEC) from a social-pedagogical tradition to an increased emphasis on learning and teaching. The phenomenon of teaching is fairly new in SAEC, and several studies show that SAEC teachers experience uncertainty in how this should be interpreted and put into practice. In this research overview, the focus is on teaching and how it is elucidated in relation to Swedish SAEC practice. The purpose of the study is to describe what characterizes teaching in SAEC in Swedish research over twenty years. The method is a systematic literature review (SLR) with a quantitative content analysis and a qualitative thematic analysis. The thematic analysis generated three substantive themes: teaching areas, conditions for teaching and actors’ perspectives on teaching. The results show that an interest in teaching as a phenomenon has emerged in recent years, but that there are few studies that explicitly address this. Instead, a majority of the studies deal with teaching implicitly and touch on areas that can be seen to be related to SAEC teaching. The study shows the importance of more research, based on different perspectives and approaches, being carried out in relation to teaching in SAEC.
Empowerment, Motivation, and Training: Key Drivers of Employee Performance in Information Technology Sector
Authors: Lama Padam Bahadur , Sigdel Smriti 
Published: January 2025

Abstract
The extensive literature reflected the association between employee empowerment, financial motivation, employee training and employee performance, and empirical inconsistency existed in distinct contexts. This study examines the effect of employee empowerment, financial motivation, and employee training on employee performance in the information technology sector of Nepal. Thus, the study aims to fill up the gap in the literature, testing the research hypothesis through positivism and deductive approaches. A total of 300 structured questionnaires were disseminated among the employees working in the information technology sector in Kathmandu, Nepal, to accumulate cross-sectional primary sources of data. Only 196 (65.33 per cent) useful questionnaires were received back. Descriptive, correlation, and regression analyses are analytical statistical techniques adopted in the study to reflect the profile of respondents, assess the relationship association, and examine their effects. Additionally, internal consistency was tested with Cronbach alpha, evidencing the reliability as all values of Cronbach alpha > 0.70. The findings of the study revealed that all the variables comprising employee empowerment, financial motivation, and employee training have a positive association with employee performance and reflect a significant effect on employee performance in the information technology sector in Kathmandu, Nepal. These findings suggest that decision-makers in organizations benefit from performance enhancement through employee empowerment, financial motivation, and employee training.