bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Matrix Stiffness Promotes Slow Muscle Fibre Regeneration After Skeletal Muscle Injury
Authors: Wang Dongmei , Wu Jiahong , Xu Zeyu , Jia Jinning , Lai Yimei , He Zhihua 
Published: February 2025

ABSTRACTThe global prevalence of skeletal muscle diseases has progressively escalated in recent years. This study aimed to explore the potential role of matrix stiffness in the repair mechanisms following skeletal muscle injury. We observed an increase in muscle stiffness, a significant rise in the number of type I muscle fibres and a notable elevation in mRNA expression levels of Myh7/2 alongside a decrease in Myh1/4 on day 3 post tibialis anterior muscle injury. To replicate these in vivo changes, C2C12 cells were cultured under high matrix stiffness conditions, and compared to those on low matrix stiffness, the C2C12 cells cultured on high matrix stiffness showed increased expression levels of Myh7/2 mRNA and production levels of MYH7/2, indicating differentiation into slow‐twitch muscle fibre types. Furthermore, up‐regulation of DRP1 phosphorylation along with elevated F‐actin fluorescence intensity and RHOA and ROCK1 production indicates that high matrix stiffness induces cytoskeletal remodelling to regulate mitochondrial fission processes. Our data also revealed up‐regulation in mRNA expression level for Actb, phosphorylation level for DRP1, mitochondrial quantity and MYH7/2 production level. Importantly, these effects were effectively reversed by the application of ROCK inhibitor Y‐27632, highlighting that targeting cytoskeletal dynamics can modulate myogenic differentiation pathways within C2C12 cells. These findings provide valuable insights into how matrix stiffness influences fibre type transformation during skeletal muscle injury repair while suggesting potential therapeutic targets for intervention.
Phylogenetic Diversity and Geographic Distribution of Atlantic Salmon Calicivirus in Major Salmon Farming Regions
Authors: Costa Vincenzo A. , Mikalsen Aase B. , Samsing Francisca 
Published: February 2025

ABSTRACTSalovirus is a genus within the family Caliciviridae, which contains a single member species, Salovirus nordlandense, also known as Atlantic salmon calicivirus (ASCV). While previous work has shown that ASCV can replicate in fish cell lines and establish systemic infection in vivo, its exact role in disease remains unclear and very little is known about its geographic distribution and evolution among Atlantic salmon. To expand the phylogenetic range of ASCV and better understand its potential role in disease, we screened publicly available transcriptomes for ASCV‐like sequences. Notably, we detected ASCV in sequencing projects of Atlantic salmon (Salmo salar) (n = 40) and wild common whitefish (Coregonus lavaretus) (n = 1), across Chile, Scotland and Norway. Our phylogenetic analysis identified two viral species, which we provisionally name Salovirus nordlandense 1 and 2, each containing distinct genotypes. Both viral species were found in all three countries, with no clear geographic pattern, indicating that saloviruses have spread through the Atlantic salmon trade. It was notable that 88% of these transcriptomes were generated for the study of other pathogens, including infectious salmon anaemia virus, piscine myocarditis virus and Piscirickettsia salmonis, suggesting that saloviruses might be frequently associated with co‐infections. Overall, this study indicates that viruses, like ASCV, can silently spread through aquacultural practices, potentially contributing to a variety of fish diseases.
Utilization of Alternative Financial Services and the Role of Financial Capability
Authors: Chatterjee Swarn , Chang Yunhee 
Published: February 2025

ABSTRACTThis paper examines the factors associated with access to and frequency of use of alternative financial services (AFS) using a composite dataset comprising of geographic locations of AFS establishments and state payday policies merged with the geo‐coded 2018 and 2021 pooled waves of the FINRA National Financial Capability Study. The results provide mixed evidence of the association between the density of AFS providers in an area and the use of AFS. Objective financial knowledge was negatively associated with both the likelihood and frequency of AFS use. Perceived Money Management Ability (PMMA) was also negatively associated with the use of AFS but not with the frequency of AFS use. Controlling for financial access and capability variables, Black consumers and low‐income consumers were more likely to use AFS. The implications for policymakers, scholars, and researchers are discussed.
IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1
Authors: Wei Xin , Su Yanlin , Tian Wencai , Cheng Li , Yin Ling , He Xiaoxia 
Published: February 2025

AbstractBackgroundEndometriosis is a chronic inflammatory condition afflicting women of reproductive age. Our study aims to clarify the function and mechanism of insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and high mobility group box 1 protein (HMGB1) in endometriosis.MethodsHMGB1 and various N6‐methyladenosine (m6A) reader protein levels were assessed in normal, eutopic, and ectopic endometrial tissue, and a correlation analysis was conducted. The impact of IGF2BP1 knockdown on endometriosis was assessed both in vivo in rat models and in vitro in ectopic endometrial stromal cells (eESCs) using methods such as immunoblotting and mRNA quantification. The binding of IGF2BP1 to HMGB1 mRNA in eESCs was assessed using RIP‐PCR. Following transfection with sh‐IGF2BP1 and oe‐HMGB1, the expression of IGF2BP1 and HMGB1, as well as cell proliferation, invasion, and migration abilities, were measured in eESCs.ResultsIn ectopic endometrial tissue, IGF2BP1 and HMGB1 were elevated and positively correlated. Inhibition of IGF2BP1 reduced eESC proliferation, migration, invasion, and glucose intake. Meanwhile, HMGB1, PKM2, and HK2 expression were depressed. In vivo, results were consistent with in vitro. Additionally, in vivo experiments confirmed that inhibition of IGF2BP1 resulted in reduced ectopic endometrial lesion spherical volume, weight, and interstitial lesions. IGF2BP1 bound to HMGB1 mRNA and enhanced its stability by m6A modification. Conversely, when IGF2BP1 was knocked down and HMGB1 was overexpressed, the results were opposite to those observed previously.ConclusionIGF2BP1 promotes endometriosis progression by enhancing m6A modification stability of HMGB1. This study provides a theoretical basis for identifying therapeutic targets for endometriosis.
Pursuing a future leader self: A multi‐study investigation of leader identity and its motivational and behavioural outcomes
Authors: Morgan Richard H. , Braun Susanne , Epitropaki Olga 
Published: February 2025

AbstractDeveloping as a leader is widely recognized as a challenging endeavour that takes time. However, little research has been done to explain the process through which future representations of oneself as a leader relate to current leader identity and how future and current leader selves motivate action. Integrating possible selves theory with identity‐based motivation theory and across three independent studies, we test a serial‐mediation model in which a salient future leader self sequentially relates to leader identity, affective motivation to lead, and proactive leadership behaviour. Our Pilot Study (N = 186) was conducted at two time points over a year apart with employees from a manufacturing company. Study 1 (N = 265) included repeated measurement at three time points, each a month apart, with employees from different industries. Study 2 (N = 301) included repeated measurement at four time points, each 2 weeks apart, with employees from different industries. Cross‐lagged analyses provided support for our hypothesized process model and allowed us to examine reciprocal relationships. The theoretical implications for leadership and leader identity theory are discussed along with the practical implications for prospective leaders and their development in organizations.
Markov Determinantal Point Process for Dynamic Random Sets
Authors: Gouriéroux Christian , Lu Yang 
Published: February 2025

ABSTRACTThe Law of Determinantal Point Process (LDPP) is a flexible parametric family of distributions over random sets defined on a finite state space, or equivalently over multivariate binary variables. The aim of this paper is to introduce Markov processes of random sets within the LDPP framework. We show that, when the pairwise distribution of two neighboring terms follows the LDPP, both the transition distribution and the stationary distribution belong to the LDPP family as well. We explore how their parameterizations are related. We investigate various constrained model specifications, develop procedures for exploratory analysis of a series of sets, and discuss model estimation on both simulated data and topics published in National Geographic.
Hepatitis Delta and Liver Disease Among People Living With Hepatitis B With or Without HIV Co‐Infection in Senegal
Authors: Wembulua Bruce Shinga , Le Gal Fredéric , Ndiaye Ousseynou , Pandi Melissa Sandrine , Akotia Messan Kodzo , Badiane Aboubakar Sidick , Hamouda Poussyina , Tine Judicaël , Ndiaye Kiné , Béguelin Charles , Ngom Ndeye Fatou , Wandeler Gilles , Seydi Moussa , Mena Adrià Ramírez ,   SEN‐B
Published: February 2025

ABSTRACTBackground and AimsThe prevalence of hepatitis delta virus (HDV) infection among persons living with hepatitis B virus (HBV) and its impact on liver‐related complications in West Africa are ill‐defined. Wetested a large urban HBV cohort in Senegal for the presence of HDV/HBV co‐infection and evaluated its association with liver fibrosis.MethodsWe included persons with positive hepatitis B surface antigen (HBsAg) enrolled in the SEN‐B cohort since 2019. Anti‐HDV antibodies (HDVAb) were tested using the Anti‐HD Diasorin LiaisonXL test, HDV RNA was measured with RT‐qPCR and genotyping was determined through sequencing. We used multivariable logistic regression to evaluate the association between HDVAb positivity and liver fibrosis, defined as a liver stiffness measurement > 7.0 kPa.ResultsWe analysed 914 individuals with a median age of 32 years (interquartile range [IQR] 26–41), of whom 487 (53.3%) were men and 117 (12.8%) had HIV co‐infection. Thirteen participants (1.4%, 95% CI 0.8–2.4) had a positive HDVAb test, of whom 8/13 (61.5%) showed detectable HDV RNA. HDV genotype 5 was found in 75.0% of cases. In multivariable analyses, HDVAb positivity (aOR 11.7, 95% CI 3.1–45.7), male sex (aOR 5.4, 95% CI 3.1–10.3), ALT > 40 IU/L (aOR 4.4, 95% CI 2.4–8.2) and HBeAg positivity (aOR 4.6, 95% CI 1.8–11.9) were independently associated with liver fibrosis.ConclusionThe prevalence of HDV infection was low in persons living with HBV in Dakar, but those affected had a very high risk of presenting with liver cirrhosis. Efforts to improve HDV screening and management are urgently needed in Senegal.
Language, people, classrooms, world: Blending disparate theories for united language education practices
Authors: Sato Masatoshi , Thorne Steven L. , Michel Marije , Alexopoulou Theodora , Hellermann John 
Published: February 2025

AbstractWith a forward‐looking and problem‐solving mindset, this article aims to combine theoretical knowledge and empirical evidence from different schools of thought in the field of second language (L2) learning and teaching—namely, instructed second language acquisition, generative linguistics, and an ecological perspective that includes multiple frameworks. Acknowledging numerous fundamental differences in our theoretical and methodological perspectives on how to conduct research, we are united on two fronts: First, we believe that researchers with differing theoretical commitments can and should work together to advance L2 research. Second, differing theoretical beliefs are potentially of limited relevance to those who will implement our pedagogical suggestions, that is, practitioners. In this article, we first present our individual perspectives regarding L2 learning and teaching (Perspective 1 by Michel and Sato, Perspective 2 by Alexopoulou, and Perspective 3 by Thorne and Hellermann). In the final section of the article, we unite our voices by prioritizing the educational practices upon which we agree, including the fact that all L2 learners bring their individual backgrounds into the classroom, the necessity of L2 use for L2 learning, and the role of L2 education for people's overall quality of life.
The Evolution of Talysh Ethnic Identity: From Soviet Manipulation to Contemporary Reality
Authors: Kokaisl Petr 
Published: February 2025

ABSTRACTThe article delves into the historical and contemporary aspects of the Talysh people's ethnic identity, tracing its evolution from the Russian Empire, through the Soviet Union's nationality policies, to the current situation in independent Azerbaijan. It highlights the Soviet era's impact on Talysh identity, including forced assimilation and demographic manipulations, while emphasising the resurgence of Talysh culture through digital media in recent years. This resurgence serves both as a form of resistance against assimilation and a means to promote cultural preservation and awareness. The study underscores the importance of digital platforms in facilitating the Talysh people's efforts to reclaim and revitalise their heritage, language and traditions, offering insights into the broader implications for ethnic minority groups navigating identity preservation within and beyond national borders.
Exploring the perceptions of Chinese adults toward overweight and obesity: A systematic literature review
Authors: Wang‐Chen Yixi , Yang Hui , Kellow Nicole J. , Choi Tammie S. T. 
Published: February 2025

SummaryIntroductionThe prevalence of obesity among the Chinese population has increased more than three‐fold over the last twenty years. It is crucial to understand Chinese people's perceptions toward obesity to inform effective weight management initiatives. This bilingual systematic review aimed to synthesize the existing literature regarding the perceptions of Chinese adults toward overweight and obesity and provide insight on methodological implications and future research directions.MethodSix databases were searched from inception to 8th January 2025. Studies were included if they were published in English or Chinese, investigated perceptions toward overweight and obesity, and focused on Chinese adults living in or outside of Mainland China. Thematic synthesis was employed for data analysis.ResultsFifty‐three studies (24 in English, 29 in Chinese) were included, involving 83,688 participants. Three themes were identified; (1) Chinese adults connected obesity with appearance more than with health, (2) Chinese adults lacked practical knowledge to manage obesity, and (3) living with obesity was perceived as a solitary journey.ConclusionMost studies were conducted on Chinese people within the healthy weight range, who predominantly focused on appearance‐oriented weight perception. There was a strong motivation for weight control, but a lack of practical weight loss strategies among Chinese adults.Practitioner applications
The lack of practical weight management knowledge and weight loss failures lead to low self‐efficacy, which may be mistaken as low motivation for weight management among Chinese adults. However, Chinese adults generally have the motivation to control their weight. It is important to empower Chinese people living with overweight or obesity with practical skills and increase self‐efficacy through a multidisciplinary and affordable approach.
The psychological burden caused by obesity stigma and the influence of Chinese culture makes the weight management journey lonely and challenging for Chinese adults living with overweight and obesity. Practitioners may need to openly address these issues and help reduce the mental burden toward more effective weight loss interventions.
Accelerations of the Phanerozoic biogeosystems
Authors: Shang Haitao 
Published: February 2025

AbstractBiogeosystems underwent significant changes during the Phanerozoic Eon. Substantial efforts have been dedicated to reconstructing the biological metrics and environmental variables characterizing the evolutionary trajectories of deep‐time biogeosystems and investigating the mechanisms responsible for variations in these quantities. The accelerations (i.e. rates of change in the variation rates) of these quantities, however, have rarely been studied. This work explores the dynamical modes and statistical properties of the accelerations of genus richness, origination, extinction, atmospheric CO2 level, and global average temperature in the Phanerozoic. Statistical assessments show that the accelerations of these quantities systematically exhibit scale‐invariant behaviours. Moreover, correlation analyses indicate that the accelerations of genus richness, origination, extinction, and global average temperature are moderately or weakly correlated with one another, while they are all uncorrelated with the acceleration of the atmospheric CO2 level. These results suggest that the acceleration is an effective concept for probing biological and geological evolution and offers insights into the internal interactions, dynamics, and stability of the Phanerozoic biogeosystems.
The risk factors for preschoolers’ behavioral problems in a low/middle‐income country
Authors: Ilter Bahadur Evin , Zengin Akkus Pınar , Yan Mehmet , Yılmaz Celebi Miray , İnal Akkaya Mine , Ozdemir Gökçenur , Baran Remziye , Celik Nuran , Ozdemir Asena Ayca , Kanık Ali , Ozmert Elif Nursel 
Published: February 2025

AbstractBackgroundChildren have a greater risk of mental health problems in low/middle‐income countries. Determining the risk factors and earlier identification of young children at high risk for behavioral problems are central to cost‐effective intervention with positive long‐term outcomes. The aim of this study was to examine the prevalence and risk factors of behavioral problems of preschoolers in three different cities located in eastern, western, and central Türkiye, a low/middle‐income country.MethodsIn total, 300 children (4–6 years old) without any chronic diseases participated the study. The parents completed the Children's Behavior Checklist/4‐18 (CBCL/4‐18), the Children's Sleep Habits Questionnaire, the Pittsburgh Sleep Quality Index, and the Beck Depression Inventory. Daily activities were evaluated using questionnaires that were specifically developed for the present study.ResultsBased on the CBCL4‐18, 12.3% of children were at high risk for behavioral problems. Paternal unemployment, screen time, maternal depressive symptoms, and maternal and child sleep problems were associated with internalizing behavioral problems; maternal depressive symptoms and watching videos on touch‐screen devices were associated with externalizing behavioral problems. Total behavioral problems were associated with maternal unemployment, maternal depressive symptoms, being the eldest child, and child sleep problems.ConclusionPreventable risk factors such as daily activities and maternal mental health should be evaluated as well as sociodemographic factors among preschoolers who may be at high risk of behavioral problems. The results of this study contribute toward drawing attention to preventable risk factors in a low/middle‐income country.
OsWNK9 mitigates salt stress by promoting root growth and stomatal closure in rice
Authors: Negi Yogesh , Kumar Kundan 
Published: February 2025

AbstractSalinity stress severely affects rice growth and reduces its productivity. With No Lysine Kinases (WNKs) are serine/threonine kinases emerging as potential candidate genes due to their involvement in various abiotic stress tolerance responses. However, studies providing mechanistic insights into the roles of WNKs in plants remain scarce. In the present study, OsWNK9‐overexpressing rice lines showed strong tolerance to salinity stress. Overexpression of OsWNK9 also triggered the accumulation of abscisic acid (ABA) and restored indole‐3‐acetic acid (IAA) concentrations in roots, triggering stomatal closure in shoots and maintaining cell expansion of the root epidermal cells when challenged with salt treatment. The overexpression lines showed increased activity of antioxidant enzymes, which further mitigated ROS‐mediated cellular damage under salinity stress. We also identified that OsWNK9 interacts with Receptor for Activated Kinase C1A (RACK1A), ABA‐8′‐hydroxylase, and (Vacuolar Type ATPase) V‐Type ATPase. Taken together, our findings suggest that OsWNK9 expression is warranted under salinity stress and exerts its effects by interacting with its downstream targets and by increased accumulation of ABA and IAA, thereby regulating seed germination, stomatal activity, improved root growth, and ionic homeostasis, which all contribute to significantly higher yield produced per plant under long term salinity stress.
New insights into rice phenology: discovering the effect of insolation on heading response
Authors: Kim Ju‐Hee , Jo So‐Hye , Moon Ji‐Hyeon , Yang Seo‐Yeong , Baek Jae‐Kyeong , Song Yeong‐Seo , Shon Ji‐Young , Lee Hyeon‐Seok 
Published: February 2025

AbstractPrecise growth management is required for climate‐smart and sustainable crop production in response to climate change, with the heading stage being the most important. Research on the control of heading in rice (Oryza sativa) has mainly focused on day length and temperature; however, research on the effects of insolation is limited. Therefore, this study analyzed the differences in rice growth and heading responses under different light intensity and temperature conditions. Five early‐maturing and seven medium–late‐maturing rice varieties were used for each japonica heading ecology type. Our results showed that leaf age development, an indirect measure of rice phenological development, was inhibited under low light intensity and low‐temperature conditions. Accordingly, the heading date was also delayed by approximately 18 days at low temperatures and 21 days at low light intensity, with no difference among ecotypes. We also found an interaction between temperature and light intensity, with the light intensity‐mediated delay in heading date being affected more by high temperatures. This study demonstrated that light intensity and temperature have a major effect on heading date variation, suggesting that the impact of insolation must be considered for the accurate prediction of heading stage variation. These results could shed new light on rice phenology research and contribute to the implementation of precision agriculture.