bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implikasi UU No. 25 Tahun 2007 Tentang Penanaman Modal Terhadap Peningkatan Investasi Di Provinsi Jambi
Authors: Budi S Eko 
Published: August 2021

Hukum dan ekonomi harus berjalan dalam suatu wadah yang harmonis dan diarahkan sebaik-baiknya untuk kesejahteraan rakyat, salah satu upaya untuk mensejahterakan rakyat adalah dengan menggerakkan perekonomian melalui penciptaan iklim dunia usaha yang kondusif. Implikasi peraturan perundang-undangan diharapkan dapat mendorong peningkatan investasi di Indonesia, baik penanaman modal dalam negeri maupun asing. Karena Undang-Undang Penanaman Modal dibentuk dan dibangun dengan pertimbangan untuk mewujudkan masyarakat adil dan makmur berdasarkan Pancasila dan Undang-Undang Dasar Negara Republik Indonesia 1945 yang berkelanjutan dengan berlandaskan demokrasi ekonomi untuk mencapai tujuan bernegara.
Hasil penelitian menunjukan bahwa implikasi UU No. 25 tahun 2007 tentang Penanaman Modal (UUPM) merupakan landasan bagi pembentukaan Perda Propinsi Jambi Nomor 10 tahun 2012 tentang Pemberian Insentif dan Kemudahan Penanaman Modal sehingga dapat mempercepat pembangunan perekonomian daerah, mengolah potensi ekonomi menjadi kekuatan ekonomi riil dengan menggunakan modal yang berasal dari dalam negeri maupun dari luar negeri, sedangkan untuk meningkatkan investasi penanam modal perlu diciptakan iklim penanaman modal yang kondusif, promotif, memberikan kepastian hukum, keadilan, dan efisien dengan tetap memperhatikan kepentingan perekonomian daerah.
Prioritizing Dose in Music-Listening Intervention Research
Authors: Kiernan Jason Micheal 
Published: August 2021

Music listening interventions (MLI) have grown into a major subcategory in the world of complementary and alternative medicine research. These studies have led to an epistemic explosion in MLI clinical application across many disciplines. However, this body of research still contains a critical handicap that will limit its potential: dose and dosing. Inconsistencies in how much of an MLI a research participant receives in a study will continue to impact generalizability until an MLI's dose is both defined and incorporated into clinical trials. This brief paper explores MLI dose, and attempts to frame MLI dose research as a priority for all researchers who utilize this intervention in their studies.
Modulating the Verwey Transition of Epitaxial Magnetite Thin Films by Ionic Gating
Authors: Hou Yanliang , Liu Yang , Yang Xuxin , Mao Hongying , Shi Zhong , Wu Shuxiang , Lu Bin , Ye Quan‐Lin , Ye Jianting 
Published: August 2021

AbstractUnderstanding the Verwey transition in magnetite (Fe3O4), a strongly correlated magnetic oxide, is a one‐century‐old topic that recaptures great attention because of the recent spectroscopy studies revealing its orbital details. Here, the modulation of the Verwey transition by tuning the orbital configurations with ionic gating is reported. In epitaxial magnetite thin films, the insulating Verwey state can be tuned continuously to be metallic showing that the low‐temperature trimeron states can be controllably metalized by both the gate‐induced oxygen vacancies and proton doping. The ionic gating can also reverse the sign of the anomalous Hall coefficient, indicating that the metallization is associated with the presence of a new type of carrier with competing spin. The variable spin orientation associated with the sign reversal is originated from the structural distortions driven by the gate‐induced oxygen vacancies.
Multi‐Sites Electrocatalysis in High‐Entropy Alloys
Authors: Li Hongdong , Lai Jianping , Li Zhenjiang , Wang Lei 
Published: August 2021

AbstractHigh‐entropy alloys (HEAs) have attracted widespread attention in electrocatalysis due to their unique advantages (adjustable composition, complex surface, high tolerance, etc.). They allow for the formation of new and tailorable active sites in multiple elements adjacent to each other, and the interaction can be tailored by rational selection of element configuration and composition. However, it needs to be further explored in catalyst design, the interaction of elements, and the determination of active sites. This review article focuses on the important progress for multi‐sites electrocatalysis in HEAs. The classification is done on the basis of catalytic reaction, including hydrogen evolution reaction, oxygen evolution reaction, oxygen reduction reaction, alcohol oxidation reaction, carbon dioxide reduction reaction, and nitrogen reduction reaction. Based on experiments and theories, a more in‐depth exploration of the high catalytic activity of HEAs will be conducted, including the selection of elements (the special role of each element in catalysis) and the multi‐sites effect. This review can provide the basis for the element selection and design of HEAs in some reactions, to adjust the compositions of HEAs to improve their intrinsic activity. Furthermore, the remaining challenges and future directions for promising research fields are also provided.
Exceptionally Robust Face‐Sharing Motifs Enable Efficient and Durable Water Oxidation
Authors: Guan Daqin , Zhang Kaifeng , Hu Zhiwei , Wu Xinhao , Chen Jeng‐Lung , Pao Chih‐Wen , Guo Yanan , Zhou Wei , Shao Zongping 
Published: August 2021

AbstractCorner‐sharing oxides usually suffer from structural reconstruction during the bottleneck oxygen‐evolution reaction (OER) in water electrolysis. Therefore, introducing dynamically stable active sites in an alternative structure is urgent but challenging. Here, 1D 5H‐polytype Ba5Bi0.25Co3.75FeO14−δ oxide with face‐sharing motifs is identified as a highly active and stable candidate for alkaline OER. Benefiting from the stable face‐sharing motifs with three couples of combined bonds, Ba5Bi0.25Co3.75FeO14−δ can maintain its local structures even under high OER potentials as evidenced by fast operando spectroscopy, contributing to a negligible performance degradation over 110 h. Besides, the higher Co valence and smaller orbital bandgap in Ba5Bi0.25Co3.75FeO14−δ endow it with a much better electron transport ability than its corner‐sharing counterpart, leading to a distinctly reduced overpotential of 308 mV at 10 mA cm−2 in 0.1 m KOH. Further mechanism studies show that the short distance between lattice‐oxygen sites in face‐sharing Ba5Bi0.25Co3.75FeO14−δ can accelerate the deprotonation step (*OOH + OH− = *OO + H2O + e−) via a steric inductive effect to promote lattice‐oxygen participation. In this work, not only is a new 1D face‐sharing oxide with impressive OER performance discovered, but also a rational design of dynamic stable and active sites for sustainable energy systems is inaugurated.
Liquid–Liquid Phase Separation of the Green Mussel Adhesive Protein Pvfp‐5 is Regulated by the Post‐Translated Dopa Amino Acid
Authors: Deepankumar Kanagavel , Guo Qi , Mohanram Harini , Lim Jessica , Mu Yuguang , Pervushin Konstantin , Yu Jing , Miserez Ali 
Published: August 2021

AbstractThe underwater adhesive prowess of aquatic mussels has been largely attributed to the abundant post‐translationally modified amino acid l‐3,4‐dihydroxyphenylalanine (Dopa) in mussel foot proteins (MFPs) that make up their adhesive threads. More recently, it has been suggested that during thread fabrication, MFPs form intermediate fluidic phases such as liquid crystals or coacervates regulated by a liquid–liquid phase separation (LLPS) process. Here, it is shown that Dopa plays another central role during mussel fiber formation, by enabling LLPS of Pvfp‐5β, a main MFP of the green mussel Perna viridis. Using residue‐specific substitution of Tyrosine (Tyr) for Dopa during recombinant expression, Dopa‐substituted Pvfp‐5β is shown to exhibit LLPS under seawater‐like conditions, whereas the Tyr‐only version forms insoluble aggregates. Combining quantum chemistry calculations and solution NMR, a transient H‐bonding network requiring the two hydroxyl groups of Dopa is found to be critical to enable LLPS in Dopa‐mutated Pvfp‐5β. Overall, the study suggests that Dopa plays an important role in regulating LLPS of MFPs, which may be critical to concentrate the adhesive proteins at the plaque/substrate interface and therefore produce a more robust adhesive. The findings also provide molecular‐level lessons to guide biomanufacturing of protein‐based materials such as bioadhesives and load‐bearing fibers.
Selective Thrombosis of Tumor for Enhanced Hypoxia‐Activated Prodrug Therapy
Authors: Ma Zhaoyu , Zhang Yifan , Dai Xinxin , Zhang Weiyun , Foda Mohamed F. , Zhang Jin , Zhao Yanli , Han Heyou 
Published: August 2021

AbstractOne of the main challenges for tumor vascular infarction in combating cancer lies in failing to produce sustained complete thrombosis. Inspired by the capability of vascular infarction in blocking the delivery of oxygen to aggravate tumor hypoxia, the performance of selective tumor thrombus inducing hypoxia activation therapy to improve the therapeutic index of coagulation‐based tumor therapy is presented. By encapsulating coagulation‐inducing protease thrombin and a hypoxia‐activated prodrug (HAP) tirapazamine into metal–organic framework nanoparticles with a tumor‐homing ligand, the obtained nanoplatform selectively activates platelet aggregation at the tumor to induce thrombosis and vascular obstruction therapy by the exposed thrombin. Meanwhile, the thrombus can cut off the blood oxygen supply and potentiate the hypoxia levels to enhance the HAP therapy. This strategy not only addresses the dissatisfaction of vascular therapy, but also conquers the dilemma of inadequate hypoxia in HAP treatment. Since clinical operations such as surgery can be used to induce coagulation, coagulation‐based synergistic therapy is promising for translation into a clinical combination regimen.
Optimizing the Iodide/Iodonium/O2 Oxidation Cycle Enhances the Scope, Selectivity, and Yields of Hydroiodic Acid‐Catalyzed Multicomponent Cyclocondensation Reactions
Authors: Scott David E. , Aloisio Mark D. , Rodriguez Jose F. , Morimoto Masato , Hamilton Robin J. , Brown Orain , Tykwinski Rik R. , Stryker Jeffrey M. 
Published: August 2021

AbstractCatalytic iodine in the presence of water acts indirectly as a source of Brønsted acid and, concurrently, generates iodonium ion and hydrogen peroxide, which mediate the final oxidative aromatization step in the multicomponent cyclocondensation of an aromatic amine and two aliphatic aldehyde compounds. The oxidative cycle in this and related iodine‐catalyzed reactions is seldom discussed, generally unoptimized, and rarely investigated in detail. This work establishes that two independent catalytic cycles (H+ and I−/I+) drive such multicomponent cyclocondensation/ oxidation reactions, provided that the oxidant is generated in sufficient concentration to inhibit oxidation of the dihydroquinoline by the intermediate iminium cation. The complementary dual catalytic cycles, when optimized, act in concert to suppress side product formation, which simplifies isolation and purification of the self‐aggregating products, and increases the efficiency and scope of the Wang‐Kozlov multicomponent reaction.magnified image
Suppressing Dissolution of Pt‐Based Electrocatalysts through the Electronic Metal–Support Interaction
Authors: Lin Gaoxin , Ju Qiangjian , Jin Yan , Qi Xiaohuan , Liu Weijing , Huang Fuqiang , Wang Jiacheng 
Published: August 2021

AbstractSuppressing the Pt dissolution still remains a big challenge in improving the long‐term stability of Pt‐based catalysts in electrochemical energy conversion. In this work, the degradation of Pt nanoparticles is successfully suppressed via weakening the Pt–O dipole effect by adjusting the electronic structure of surface Pt atoms. The specially designed graphitic‐N‐doped carbon nanosheets with balanced N content and graphitization degree as well as fewer defects are prepared for anchoring Pt nanoparticles to enhance the electronic metal–support interaction. This can accelerate the electron transfer from Pt to substrate, decrease the surface electron density of Pt, and attenuate the Pt–O interaction. As a result, the rate of Pt dissolution decreases by 95% compared to that of commercial Pt/C toward the oxygen reduction reaction and thus the catalytic stability is significantly improved in the electrochemical accelerated durability test. The theoretical simulation shows that the inhibition of surface Pt dissolution is attributed to the enhanced energy barrier in the initial relaxation process.
Probing Charge Carrier Properties and Ion Migration Dynamics of Indoor Halide Perovskite PV Devices Using Top‐ and Bottom‐Illumination SPM Studies
Authors: Alosaimi Ghaida , Shin So Jeong , Chin Robert Lee , Kim Jong H. , Yun Jae Sung , Seidel Jan 
Published: August 2021

AbstractRecently, perovskite solar cells have shown excellent performance under indoor light conditions. In a new approach using directional illumination combined with nanoscale scanning probe microscopy (SPM) characterization, morphology dependent‐charge transport measurements are performed to provide a comprehensive understanding of the optoelectronic behavior of (FAPbI3)0.85(MAPbBr3)0.15 containing 5 vol% cesium (Cs5vol%) with various electron transport layers (ETLs), i.e., SnO2, c‐TiO2, and [6,6]‐phenyl‐C61‐butyric acid methyl ester/SnO2 under indoor light. This approach allows the identification of the charge transport properties of the perovskite film and the perovskite/ETL interface separately. The light is applied from the top of the perovskite film to study the electronic properties of the surface. Lower photocurrent and lower surface photovoltage (SPV) are observed under top‐illumination conditions. The electronic interface behavior is investigated using bottom‐illumination and short excitation wavelengths, such as blue LED light. Higher photocurrent and higher SPV are observed under blue light illumination from the bottom. These results suggest that the charge transport capability is enhanced near the p–n junction. Conductive atomic force microscopy results show that SnO2 enhances the charge collection properties of the perovskite's grain boundaries (GBs). Kelvin probe force microscopy results confirm that SnO2 exhibits homogeneous and high surface potential because of the lowest trap states at GBs.
Highly Selective Monoalkylation of Active Methylene and Related Derivatives using Alkylsilyl Peroxides by a Catalytic CuI‐DMAP System
Authors: Zhou Canhua , Lv Jiamin , Xu Weiping , Lu Hanbin , Kato Terumasa , Liu Yan , Maruoka Keiji 
Published: August 2021

AbstractA new approach for highly selective monoalkylation of active methylene and related derivatives using various types of alkylsilyl peroxides in the presence of copper catalysts under mild conditions has been developed to a synthetically useful level. This approach has a wide substrate scope in terms of both active methylene compounds and alkylsilyl peroxides. In addition, nitroalkanes can also be employed for a copper‐catalyzed selective monoalkylation with alkylsilyl peroxides. The participation of radical species was proposed in the present monoalkylation reactions by the mechanistic study.
Anything for a cheerio: Brown capuchins (Sapajus [Cebus] apella) consistently coordinate in an Assurance Game for unequal payoffs
Authors: Robinson Lauren M. , Martínez Mayte , Leverett Kelly L. , Rossettie Mattea S. , Wilson Bart J. , Brosnan Sarah F. 
Published: August 2021

AbstractUnequal outcomes disrupt cooperation in some situations, but this has not been tested in the context of coordination in economic games. To explore this, we tested brown capuchins (Sapajus [Cebus] apella) on a manual version of the Stag Hunt (or Assurance) Game, in which individuals sequentially chose between two options, Stag or Hare, and were rewarded according to their choices and that of their partner. Typically, coordination on Stag results in an equal highest payout, whereas coordinating on Hare results in a guaranteed equal but lower payoff and uncoordinated play results in the lowest payoff when playing Stag. We varied this structure such that one capuchin received double the rewards for the coordinated Stag outcome; thus, it was still both animals' best option, but no longer equally rewarding. Despite the inequality, capuchins coordinated on Stag in 78% of trials, and neither payoff structure nor their partner's choice impacted their decision. Additionally, there was no relationship between self‐scratching, a measure of stress in capuchins, and choices. After completing the study, we discovered our reward, cheerios, was sufficiently valuable that in another study, capuchins never refused it, so post hoc we repeated the study using a lower value reward, banana flavored pellets. Capuchins completed only 26% of the pellet trials (compared to 98% with cheerios), constraining our ability to interpret the results, but nonetheless the monkeys showed a decrease in preference for Stag, particularly when they received fewer rewards for the coordinated Stag outcome. These results reinforce capuchins' ability to find coordinated outcomes in the Stag Hunt game, but more work is needed to determine whether the monkeys did not mind the inequality or were unwilling to sacrifice a highly preferred food to rectify it. In either case, researchers should carefully consider the impact of their chosen rewards on subjects' choices.
Synthesis of Chiral Spirolactams via Sequential C−H Olefination/Asymmetric [4+1] Spirocyclization under a Simple CoII/Chiral Spiro Phosphoric Acid Binary System
Authors: Yuan Wen‐Kui , Shi Bing‐Feng 
Published: August 2021

AbstractAn unprecedented enantioselective synthesis of spiro‐γ‐lactams via a sequential C−H olefination/asymmetric [4+1] spirocyclization under a simple CoII/chiral spiro phosphoric acid (SPA) binary system is reported. A range of biologically important spiro‐γ‐lactams are obtained with high levels of enantioselectivity (up to 98 % ee). The concise, asymmetric synthesis of an aldose reductase inhibitor was successfully achieved. Notably, contrast to previous reports that relied on the use of cyclopentadienyl or its derivatives (achiral Cp*, CptBu, or chiral Cpx) ligated CoIII complexes requiring tedious steps to prepare, cheap and commercially available cobalt(II) acetate tetrahydrate was used as an efficient precatalyst.
Lipase‐mediated synthesis of neopentyl glycol diester using a combination of reduced and standard pressure
Authors: Kim Ji Won , Kim Byung Hee , Kim Yangha , Lee Moon‐Won , Im Dong Joong , Kim In‐Hwan 
Published: August 2021

AbstractNeopentyl glycol (NPG) diester is a biodegradable lubricant used in the machinery industry as it is suitable for the low‐temperature environment. NPG diester was successfully synthesized with fatty acid and NPG using immobilized lipase. Immobilization was carried out with a liquid enzyme, Eversa® Transform 2.0 (from Thermomyces lanuginosus) and Lewatit VP OC 1600 as a carrier. The Eversa immobilized lipase prepared in this study was compared with commercial lipases, such as Novozym 435, Lipozyme RM IM, and Lipozyme TL IM. The Eversa immobilized lipase was the most effective biocatalyst for the synthesis of NPG diesters. The effects of enzyme loading and temperature on conversion were explored at a standard pressure of 101.3 kPa. And then, the effect of reduced pressure was investigated in the range of 1.3 to 40.0 kPa under optimum conditions obtained at standard pressure. The maximum conversion of ca. 63% was achieved at the optimal temperature of 50°C and the enzyme loading of 5% (based on the total weight of the substrate) at standard pressure after 10 h. However, the conversion to NPG diester increased markedly up to 97% after 10 h, even though reduced pressure as low as 26.7 kPa was applied. No significant differences in the conversion to NPG diester between the reactions at constant reduced pressure and the combined reaction of reduced pressure and standard pressure were observed. This pressure combination method employed in this study demonstrated a novel, energy‐saving strategy for the synthesis of NPG diester.
Recent progress in bio‐based eugenol resins: From synthetic strategies to structural properties and coating applications
Authors: Kumar Bijender , Agumba Dickens O. , Pham Duc H. , Kim Hyun Chan , Kim Jaehwan 
Published: August 2021

AbstractThis review article describes the synthesis route of eugenol (4‐Allyl‐2‐methoxyphenol, EU)‐based resins, properties, and their use in coating application. EU‐based resin is an attractive phenolic‐based material with outstanding properties such as thermal stability, water‐resistant, antioxidant, and flame retardancy performance. However, limited research articles on EU‐based resins have been published recently for the coating application. A growing interest in developing design strategies and properties of EU‐based resins has emerged due to their low cost, non‐toxic, and environment‐friendly behaviors. This review article aims to highlight EU‐based resins, including epoxy and non‐epoxy ones, and critically discuss their properties and opportunities in coating application, which may facilitate their utilization in academia and industries.
Tuning enzymatic properties by protein engineering toward catalytic tetrad of carbonyl reductase
Authors: Cheng Feng , Zhai Qiu‐Yao , Gao Xiao‐Fan , Liu Hua‐Tao , Qiu Shuai , Wang Ya‐Jun , Zheng Yu‐Guo 
Published: August 2021

AbstractEnzyme engineering toward catalytic‐tetrad residues usually results in activity loss. Unexpectedly, we found that a directed evolution campaign yielded a beneficial residue A100 in KmCR (a carbonyl reductase from Kluyveromyces marxianus ZJB14056), which is a residue of catalytic tetrad and conserved according to multiple sequence alignment. Inspired by this finding, we performed saturation mutagenesis on all the four residues of catalytic tetrad of KmCR. A number of variants with improved enzymatic activities were obtained. Among them, the variant KmCR_A100S exhibited increased catalytic efficiency (kcat/KM = 47.3 s−1·mM−1), improved stereoselectivity (from moderate selectivity (deP = 66.7%) to strict (S)‐selectivity (deP > 99.5%)), and extended substrate scope, compared to those of KmCR_WT. In silico analysis showed that a relay system was rebuilt in KmCR via the beneficial residue S100. Furthermore, comparison of 11 protein engineering campaigns indicated that the beneficial position is easily overlooked due to the long distance (>10 Å) from ketone substrates. Since CRs share similar catalytic mechanism, the knowledge gained from this study has universal significance to CR engineering.
Probing specificities of alcohol acyltransferases for designer ester biosynthesis with a high‐throughput microbial screening platform
Authors: Lee Jong‐Won , Seo Hyeongmin , Young Caleb , Trinh Cong T. 
Published: August 2021

AbstractAlcohol acyltransferases (AATs) enables microbial biosynthesis of a large space of esters by condensing an alcohol and an acyl‐CoA. However, substrate promiscuity of AATs prevents microbial biosynthesis of designer esters with high selectivity. Here, we developed a high‐throughput microbial screening platform that facilitates rapid identification of AATs for designer ester biosynthesis. First, we established a microplate‐based culturing technique with in situ fermentation and extraction of esters. We validated its capability in rapid profiling of the alcohol substrate specificity of 20 chloramphenicol acetyltransferase variants derived from Staphylococcus aureus (CATSa) for microbial biosynthesis of acetate esters with various exogeneous alcohol supply. By coupling the microplate‐based culturing technique with a previously established colorimetric assay, we developed a high‐throughput microbial screening platform for AATs. We demonstrated that this platform could not only probe the alcohol substrate specificity of both native and engineered AATs but also identify the beneficial mutations in engineered AATs for enhanced ester synthesis. We anticipate the high‐throughput microbial screening platform provides a useful tool to identify novel wildtype and engineered AATs that have important roles in nature and industrial biocatalysis for designer bioester production.