bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic Value of Preoperative Hematology Makers in the Classification and Molecular Subtypes of Newly Diagnosed High-Grade Gliomas
Authors: Jia Xin , Zhai Yixuan , Yang Fengdong , Wang Yiming , Wei Shuxin , Wei Xinting 
Published: July 2021

Abstract
Objective

The purpose of our study is to explore the diagnostic value of the single and combined hematological maker for the classification and isocitrate dehydrogenase (IDH)-1/2 mutations molecular subtypes of high-grade gliomas (HGGs).
Methods

A total of 354 newly diagnosed HGGs patients were included in this study. Firstly, we compared the levels of hematology indicators in the classification and molecular subtypes of HGGs. Next, the correlation between the levels of hematology indicators with basic clinical features was analyzed. Finally, the diagnostic value of the single and combined hematology indicator for identifying the classification and molecular subtypes from HGGs was performed.
Results

The level of fibrinogen (FIB) was higher in higher grade gliomas and glioblastoma multiforme IDH wild type (GBM IDH-wt). Nutrition-related indicators such as serum albumin (ALB), albumin/globulin ratio (AGR), and prognostic nutrition index (PNI) were negatively correlated with age, whereas FIB was positively associated with age. Compared with women, men with GBM had significantly higher AGR and lower serum globulin (GLOB). We found that the best single and combined indicator for identifying GBM and GBM IDH-wt from HGGs were FIB [0.595 (0.519–0.672) and 0.615 (0.546–0.684)] and age + FIB [0.712 (0.642–0.783) and 0.726 (0.662–0.791)], respectively.
Conclusions

Preoperative hematological indicators have high diagnostic value for GBM and GBM IDH-wt from HGGs, especially FIB combined age.
Effect of Peridontal Interventions on Characteristics of the Periodontal Microbiota: A Systematic Review and Meta-analysis
Authors: Nath Sonia , Pulikkotil Shaju , Weyrich Laura , Zilm Peter , Kapellas Kostas , Ketagoda Kevin , Jamieson Lisa 
Published: July 2021

Abstract
Background: The aim of the systematic review was to evaluate the effect of periodontal interventions on the diversity and composition of periodontal microbiota assessed by high throughput sequencing (HTS) metagenomics analysis. Methods: An electronic search of all relevant databases was conducted from database inception to May 2021 by two independent reviewers. All clinical trials that evaluated the effect of periodontal interventions on the gingival microbiota through HTS were selected. The measures of alpha diversity was used as primary outcome; richness, Shannon diversity index, and the Chao1 index, whereas relative abundances of bacterial genera was considered as secondary outcome. The Robvis tool was used to assess the risk of bias. Results: Overall, 19 studies were eligible for the systematic review, of which 10 studies were included in the meta-analysis. Periodontal intervention for test group resulted in decrease in Shannon’s diversity, richness and Chao I index as observed from baseline to post-treatment. The most common genera found to increase after periodontal therapy were Rothia, Actinomyces, Streptococcus, Veillonella and Hemophilus and Porphyromonas, Tannerella, Fusobacterium, and Treponema decreased after periodontal therapy. Conclusion: Periodontal interventions may decrease the bacterial diversity and richness and alter the composition of oral microbiota in the short-term. Periodontal microbiota signatures could potentially be used for the assessment of periodontal intervention in the future. Further studies should implement methodological consistency to provide a more quantitative and mechanistic understanding of these approaches.
Comparative Transcriptome and DNA Methylation Analysis in Temperature-Sensitive Genic Male Sterile Wheat BS366
Authors: Liu Yong-jie , Li Dan , Gong Jie , Wang Yong-bo , Chen Zhao-bo , Pang Bin-shuang , Chen Xian-chao , Gao Jian-gang , Yang Wei-bing , Zhang Feng-ting , Tang Yi-miao , Zhao Chang-ping , Gao Shi-qing 
Published: July 2021

Abstract
Background: Known as the prerequisite component for the heterosis breeding system, the male sterile line determined the hybrid yield and seed purity. Therefore, a deep understanding of the mechanism and gene network that leads to male sterility is crucial. BS366, a temperature-sensitive genic male sterile (TGMS) line, were male sterile under cold condition (12℃ with 12 h daylight) but fertile under normal temperature (20℃ with 12 h daylight). Results: During the meiosis, BS366 was defective in forming tetrad and dyad due to the abnormal cell plate. During the pollen development, unusual vacuolated pollen that cannot accumulate starch grains at the binucleate stage was also observed. Transcriptome analysis revealed that genes involved in the meiotic process like sister chromatid segregation and microtubule-based movement were repressed, while genes involved in DNA and histone methylation were induced in BS366 under cold condition. MethylRAD was used for a reduced DNA methylation sequencing for BS366 under both cold and control conditions. The differentially methylated sites (DMSs) located in the gene region were mainly involved in carbohydrate and fatty acid metabolism, lipid metabolism, and transport. Genes differentially and methylated were mainly involved in cell division. Conclusions: These results indicated that methylation of genes involved in carbon metabolism or fatty acid metabolism would contribute to the male sterility in BS366, which will provide a novel insight into the molecular mechanism of wheat male sterility.
Effect of Gas Holdup on CO2 Biofixation by Spirulina sp. in the 20-liter Airlift Bioreactor
Authors: Zarei Zahra , Malekshahi Peyman , Morowvat Mohammad Hossein , Rahimi Rahbar , Niknezhad Seyyed Vahid 
Published: July 2021

Abstract
The rise of CO2 concentration in the Earth is a major environmental problem, which cause global warming. To solve this issue, several methods have been applied, but among these solutions using microalgae is an eco-friendly and cost-effective way of reducing carbon dioxide, as they can efficiently sequestrate CO2 and produce biomass as valuable products. In this study, hydrodynamic parameters, bubble sizes and carbon dioxide uptake were investigated in an airlift bioreactor. Experiments were studied at two different superficial gas velocities (0.185 and 0.524 cm/s) for Spirulina sp. microalgae into a 20-liter airlift bioreactor to find out the amount of carbon dioxide sequestration and cyanobacterial biomass. The highest efficiency of carbon dioxide removal and maximum dry weight of Spirulina sp. were achieved 55.48% and 0.86 g/L respectively at 5% CO2 (v/v) and superficial velocity of 0.185 cm/s. This experiment was conducted in 7 days, light intensity (2600 lux/m2), temperature (30\(\pm\)2 °C) and a light-dark cycle (12–12), which all were constant. The hydrodynamic parameters studied by Spirulina sp. demonstrated a capability of CO2 sequestration in this airlift photobioreactor.
A Nonreciprocal Angular Selective Absorber with the Special Multilayer Structure
Authors: Wan Baofei , Ma Yu , Zhou Ziwei , Zhang Dan , Zhang Hai-Feng 
Published: July 2021

Abstract
Due to the orderly design of the special anti-reflection structure and the absorption structure, the one-dimensional layered periodic structure has a good impedance matching in a certain frequency band and a large-angle range, providing for the realization of an angular selective absorber (ASA) with a high rectangle coefficient. For the sake of obtaining excellent absorptivity, the indium tin oxide (ITO) film is used, and it also acts as a function of tuning the absorption angle range (AAR) of the ASA by adjusting the plasma frequency. The proportional relationship between the thickness of the dielectric layers is also discussed to satisfy a good absorption function. At the same time, the ASA also possesses productive nonreciprocal performance (NP) and can also be controlled by the plasma frequency. The transfer matrix method is used for numerical simulation. Our special tunable ASA with the NP is relatively rare in previous studies, which can be applied to optical communications and military fields. Furthermore, we hope that the design we proposed can provide new possibilities for the development of the ASAs.
Engaging citizens in the co-production of a health system performance assessment framework: a case study in Ireland
Authors: Fernandes Óscar Brito , Barbazza Erica , Ivanković Damir , Jansen Tessa , Klazinga Niek , Kringos Dionne 
Published: July 2021

Abstract
Background

The launch in 2017 of the Irish 10-year reform programme Sláintecare represents a key commitment in the future of the health system. An important component of the programme was the development of a health system performance assessment (HSPA) framework. In 2019, the Department of Health of Ireland (DoH) and Health Service Executive (HSE) commissioned the technical support of researchers to develop an outcome-oriented HSPA framework, which should reflect the shared priorities of multiple stakeholders, including citizens. This study describes the method applied in the Irish context and reflects on the added value of using a citizen panel in the co-production of an HSPA framework.

Methods

A panel of 15 citizens was convened, recruited by a third-party company using a sampling strategy to achieve a balanced mix representing the Irish society. Panelists received lay-language preparatory materials prior to the meeting. Panelists used a three-color scheme to signal the inclusion and importance of performance measures. An exit questionnaire was administered to understand how participants experienced being part of the panel. The citizen panel was the first in a series of three panels towards the development of the HSPA framework, followed by panels including representatives of the DoH and HSE, and representatives from professional associations and special interest groups.

Results

The citizen panel generated 249 health performance measures ranging across 13 domains. Domains assessed as the most important included people-centeredness, coordination of care, and coverage. Prioritization of domains differed between panels. Citizen panelists shared a similar understanding of what a citizen panel involves and described their experience at the panel as enjoyable, interesting, and informative.

Conclusions

The engagement of citizens early on in the co-production process of the HSPA framework shaped the processes that followed, with the restating of priorities of the citizen panel informing decision-making throughout. Citizen engagement in HSPA development is essential for realizing value-based people-centered health systems and assuring an inclusive process that helps to generate trust and ownership of performance intelligence. Future research could expand on how citizen panels could be further engaged in co-creating mechanisms to assess, monitor, and report on the performance of health care systems.
Wildfire Alters the Linkage Between Total and Available Soil C:N:P Ratios and the Stoichiometric Effects on Fine Root Growth in a Chinese Boreal Larch Forest
Authors: Kong Jianjian , Xiang Xing jia , Yang Jian 
Published: July 2021

Abstract
Background and aimsWildfire is a primary driver of ecosystem functioning, and the fire-induced changes in the cycling and balance of multiple nutrients may influence the response of plant growth to burning. However, the relationships between total and available soil stoichiometry and stoichiometric effects on the growth of fine roots following fire in forests remain unclear.MethodsWe measured the total and available soil C, N and P concentrations, their ratios and fine root biomass (FRB) at an unburned control, 1-year-postfire and 11-year-postfire sites in a Chinese boreal larch forest. The relationships between soil stoichiometry and FRB were analyzed.ResultsWildfire significantly reduced the total and available soil C:N:P ratios and FRB immediately postfire. Eleven years postfire, most indicators recovered to the pre-fire levels except total soil C:P and N:P ratios, and available C:N ratio. Wildfire immediately increased the correlations between total and available soil C:N:P ratios, as well as between FRB and soil C:N:P ratios, but reduced the correlations between FRB and soil nutrient supply. These effects became weaker over time.ConclusionsThe effects of wildfire on biogeochemical processes in boreal ecosystems extend to the relationships between total and available soil stoichiometry. Wildfire strengthens the linkage between fine roots and soil stoichiometry, but weakens the effects of soil nutrient supply in the Great Xing’an Mountains. Therefore, the effects of wildfire on the coupling of soil C, N and P cycling can produce a more complex soil-plant interaction in the postfire early succession stage of boreal larch forest.
Educational Attainment in Patients With Congenital Heart Disease: a Comprehensive Systematic Review and Meta-analysis
Authors: Cocomello Lucia , Dimagli Arnaldo , Biglino Giovanni , Cornish Rosie , Caputo Massimo , Lawlor Deborah 
Published: July 2021

Abstract
Background: To determine the association between having a CHD compared with not, on educational attainment in adults. A systematic review and meta-analysisMethod: Studies were eligible if they reported the rate/odds/proportion of level of educational attainment in adults by history of CHD. Result: Out of 1537 articles screened, we identified 11 (N = 104585 participants, 10487 with CHD), 10(N = 167470 participants, 11820 with CHD), and 8 (N = 150813 participants, 9817 with CHD) studies reporting information on university education, secondary education, and vocational training, respectively in both CHD and non-CHD participants. Compared to their non-CHD peers, CHD patients were more likely not to obtain a university degree (OR=1.38, 95% CI [1.16, 1.65]), complete secondary education (OR=1.33, 95 % CI [1.09, 1.61]) or vocational training (OR= 1.11, 95%CI [0.98, 1.26]). For all three outcomes there was evidence of between study heterogeneity, with geographical area contributing to this heterogeneity. Conclusion: This systematic review identified all available published data on educational attainment in CHD patients. Despite broad inclusion criteria we identified relatively few studies that included a comparison group from the same population, and amongst those that did, few adjusted for key confounders. Pooled analyses suggest evidence of lower levels of educational attainment in patients with CHD when compared to non-CHD peers. The extent to which this may be explained by confounding factors, such as parental education, or mediated by treatments is not possible to discern from the current research literature.
Hyperconnectivity Between The Posterior Cingulate and Middle Frontal and Temporal Gyrus in Depression: Based On Functional Connectivity Meta-Analyses.
Authors: Zhu Ziqing , Wang You , Lau Way , Wei Xinhua , Liu Yingjun , Huang Ruiwang , Zhang Ruibin 
Published: July 2021

Abstract
BackgroundDisrupted whole-brain resting-state functional connectivity (RSFC) of the posterior cingulate (PCC) has been highlighted to associate with cognitive and affective dysfunction in major depressive disorder (MDD). However, prior findings showed certain inconsistency about the RSFC of the PCC in MDD. This study aims to investigate the aberrant RSFC of the PCC in MDD using anisotropic effect-size version of seed-based d mapping (AES-SDM). MethodsWeb of Science and PubMed were searched for studies investigating PCC-based RSFC in MDD. A total of 17 studies, involving 804 patients and 724 healthy controls (HCs), fit our selection criteria. Additionally, to seek for the link between functional and structural differences, we did a meta-analysis on the studies in conjunction with Voxel-based morphology (VBM) analysis. ResultsThe PCC showed higher RSFC with the left middle temporal gyrus (MTG) and the right middle frontal gyrus (MFG), and lower RSFC with the left superior frontal gyrus (SFG) and the left precuneus in patients with MDD than HCs. Notably, the left MTG and the left MFG were the overlapped regions of aberrant VBM and RSFC results.ConclusionsOur results indicated that the aberrant RSFC between the PCC and brain regions sub-serving cognitive control and emotional regulation in patients with MDD. And such functional alterations may have structural basis. These findings may underlie the mechanisms of deficits in cognitive control and emotional regulation of MDD.
Does Mobile Social Media Undermine Our Romantic Relationships? The Influence of Fear of Missing Out (FoMO) On Young People’ Romantic Relationship
Authors: Wang Lin , Qiu Junping , Yan Su , Liu Wei 
Published: July 2021

Abstract
The widespread use of social media has a trans-formative effect on people’s work and lives. With the increasing information explosion and more cases of social media addiction, users have been always worried that they have missed some information. FoMO (Fear of Missing Out) of mobile users emerges. FoMO has affected users’ interpersonal relationship and behavior in the offline environment, especially for post-90s generation users (people born in the 1990’s). This paper explores the impact of FoMO of post-90s generation mobile users on romantic relationship in the context of social media. The sample size is 274 subjects. By using questionnaire survey and regression analysis, the impacts of FoMO on romantic relationship were analyzed from the perspectives of three dimensions of FoMO: cognitive, emotional and behavioral manifestations. Results show that behavioral manifestation of FoMO has a significant negative effect on romantic relationships, while emotional and cognitive manifestations of FoMO have no significant effects on romantic relationships. This paper enriches the research on the effects of psychology and information behavior of mobile social media users on their interpersonal relationship.
Photodynamic and Anti- VEGF Therapy for Polypoidal Choroidal Vasculopathy - ‘Real World’ Outcomes in a Caucasian Population.
Authors: Gilmour Kenneth M. , Young David , Jamison Aaron , Precup Monica , Gilmour David F. 
Published: July 2021

Abstract
BackgroundThe prevalence of polypoidal choroidal vasculopathy (PCV) is significantly higher amongst Asian populations compared to Caucasian, and evidence regarding the clinical outcomes of Caucasian patients is limited. This retrospective study sought to investigate real-world clinical outcomes of Caucasian PCV patients treated with polypoidal verteporfin photodynamic therapy (PDT) in combination with anti-VEGF therapy up to 36 months post treatment. MethodsConsecutive PCV patients who received PDT between 2011 and 2017 were included. Mean change in visual acuity (VA) measured by ETDRS letter score and mean change in central subfield thickness (CST) were the main outcome measures. Data was collected at baseline, 3, 12, 24 and 36 months. Regression analyses were carried out on pre-treatment clinical features to determine if there were any factors associated with a good visual outcome (better than or equal to 70 ETDRS letters at 12 months). ResultsSeventy six patients (96% Caucasian) were included in the analysis. Mean change in VA was -1, -4, and 0 ETDRS letters at 12, 24, and 36 months respectively. CST was reduced by a mean of -51, -54, and -55 microns at 12, 24, and 36 months. Better pre-treatment VA was the only pre-treatment clinical feature associated with a good visual outcome at 12 months (OR 1.16, p<0.001).ConclusionsPDT in combination with anti-VEGF therapy maintains VA and may reduce anti-VEGF therapy burden in Caucasian patients with PCV. Better pre-treatment VA is associated with a good visual outcome.
A Pan-Cancer Analysis Revealing the Role 2 of TIGIT in Tumor Microenvironment
Authors: Wen Jie , Mao Xueyi , Cheng Quan , Liu Zhixiong , Liu Fangkun 
Published: July 2021

Abstract
T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), an immune checkpoint, plays a pivotal role in immune suppression. However its role in tumor immunity and correlation with the genetic and epigenetic alterations remains unknown.Here, we comprehensively analyzed the expression patterns of the TIGIT and its value of prognostic prediction among 33 types of cancers based on the data collected from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression projects (GTEx). Furthermore, the correlations of TIGIT with tumor-infiltrating immune cells (TIICs), immune checkpoint genes, the degree of Estimation of STromal and Immune cells in MAlignant Tumor tissues using the Expression data (ESTIMATE), tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR) genes, and DNA methyltransferases (DNMTs) were also explored. Gene functional enrichment was conducted by Gene Set Enrichment Analysis (GSEA). Our results showed that the expression of TIGIT was upregulated in most of the cancer types. Cox regression model showed that high expression of TIGIT in tumor samples correlates with poor prognosis in KIRC, KIRP, LGG, UVM, and with favorable prognosis in BRCA, CECS , HNSC, SKCM. TIGIT expression significantly correlated with TIICs and the degree of ESTIMATE in KIRC, KIRP and UVM. TIGIT expression also correlated with CTLA4, PDCD1 (PD-1), CD274 (PD-L1), ICOS in most of the cancer types. Furthermore, the expression of TIGIT was correlated with TMB, MSI, MMR genes and DNMTs in different types of cancers. GSEA analysis showed that the expression of TIGIT was related to cytokine-cytokine receptor interaction, allograft rejection, oxidative phosphorylation.These findings suggested that TIGIT could serve as a potential biomarker for prognosis and a novel target for immunotherapies in cancers.
BlueFMCW: Random Frequency Hopping Radar for Mitigation of Interference and Spoofing
Authors: Moon Thomas , Park Jounsup , Kim Seungmo 
Published: July 2021

Abstract
Radars form a central piece in a variety of emerging applications requiring higher degrees of localization. However, two problems are anticipated as more radars are deployed: viz., (i) inter-radar interference and (ii) security attacks. While many prior proposals have addressed the problems, no work in the radar literature addressed them simultaneously. In this context, we introduce a novel frequency-modulated continuous-wave (FMCW) radar scheme (namely, BlueFMCW) that aims to alleviate the damage from interference and active attacks (e.g., spoofing). The technique designs that the waveform randomly hops across multiple frequencies to dilute the damage at a certain frequency. Moreover, we propose a phase alignment algorithm to remove the phase discontinuity while combining the beat signals from the randomly-hopped chirps. The simulation results show that the proposed technique can efficiently mitigate the interference and spoofing signals in various scenarios without costing its resolution.
A method to construct the dynamic landscape of a bio-membrane with experiment and simulation
Authors: Smith Albert , Vogel Alexander , Engberg Oskar , Hildebrand Peter , Huster Daniel 
Published: July 2021

Abstract
Biomolecular function is based on a complex hierarchy of molecular motions. While biophysical methods can reveal details of specific motions, a concept for the comprehensive description of molecular dynamics over a wide range of correlation times has been unattainable. Here, we report a novel approach to construct the dynamic landscape of biomolecules, which describes the aggregate influence of multiple motions acting on various timescales and on multiple positions in the molecule. To this end, we use NMR relaxation and molecular dynamics simulation data for the characterization of lipid membranes, the most important biological interface. We develop a dynamics detector method that yields site-specific amplitudes, separated both by type and timescale of motion. This separation allows the detailed description of the dynamic landscape, which reveals vast differences in motion depending on molecular position. More generally, the method is applicable to a broad range of molecular systems, and can be adapted to other timescale-sensitive techniques.