bluuebunny/crossref_metadata_2025_split huggingface dataset:
High output power density and strong vibration durability in a modified barbell-shaped energy harvester based on multilayer Pb(In1/2Nb1/2)O3–Pb(Mg1/3Nb2/3)O3–PbTiO3 single crystals
Authors: Liu Jinfeng , Gao Xiangyu , Qiu Chaorui , Qiao Liao , Yang Jingya , Ma Ming , Song Kexin , Guo Haisheng , Xu Zhuo , Li Fei 
Published: January 2021

Traditional piezoelectric energy harvesters are made of piezoelectric ceramics with a cantilever structure, which show a low output energy density. Thus, they are difficult to meet the requirements for self-powered electronics. Herein, we report a modified barbell-shaped piezoelectric energy harvester (BSPEH) based on two d33-mode cuboid Pb(In1/2Nb1/2)O3–Pb(Mg1/3Nb2/3)O3–PbTiO3 multilayer single crystal stacks (ten wafers with a thickness of 0.5 mm and d33 ∼ 1300 pC/N). Due to the electrically parallel and series connections of multilayer piezoelectric elements and the high figure-of-merit d33 × g33 of the single crystal, the maximum power density of BSPEH could reach 39.7 mW cm−3 (under an acceleration of 5 g), which is much higher than that of traditional cantilever piezoelectric energy harvesters (CPEHs), ∼0.1 mW cm−3. A maximum output voltage of 50.4 Vp–p was obtained when two crystal stacks are connected in series, and a maximum output current of 880 µA can be obtained when two crystal stacks are connected in parallel. Furthermore, the energy harvesting properties of BSPEH stay almost the same after 106 vibration cycles, while the properties of CPEH decrease 20% after 105 vibration cycles. This work indicates that BSPEH has a great potential in the application of wireless sensor networks for realizing the self-power of the equipment.
Anti-inflammatory effects of low temperature atmospheric plasma on acute pancreatitis induced by L-arginine in rats
Authors: Sun Yuan-song , Wang Qi , Li He , Yang Min , Jin Tao 
Published: January 2021

Acute pancreatitis (AP), a sterile inflammation in local pancreas, is well-known as one of the most serious abdominal diseases. It could develop into a systemic inflammation if there is lack of instant supervision. Thus, it is important to find an effective method to solve this clinical challenge. The purpose of our work is to study the anti-inflammatory effect of low temperature atmospheric plasma (LTAP) on AP in vivo, and two treatment doses, namely, 30 s and 60 s, were used in our experiment. The optical emission spectroscopy assay proved that the LTAP produced by an arc discharge reactor contains reactive oxygen and nitrogen species. The histopathologic result showed that the LTAP treatment for 60 s can significantly mitigate AP as compared with the group treated for 30 s. Moreover, the quantity of inflammation cells treated by the LTAP treatment for 60 s and 30 s was markedly reduced, while the 60 s treatment displayed a better suppress effect on AP. Taken together, our study indicated that LTAP can be used as a promising strategy to alleviate AP.
Robustness of the remanent magnetic domain pattern formation and associated stripe-bubble transitions in Co/Pt multilayers against field sequencing
Authors: Gentillon Aaron , Richards Carson , Ortiz-Flores Luis A. , Metzner Jeremy , Montealegre David , Healey Matthew , Cardon Kelsey , Westover Andrew , Hellwig Olav , Chesnel Karine 
Published: January 2021

Thin ferromagnetic [Co/Pt] multilayers with perpendicular magnetic anisotropy exhibit a variety of nanoscopic magnetic domain patterns at remanence, from long interlaced stripes to lattices of bubbles, depending on the multilayer structure but also on the magnetic history of the sample. For optimized structural parameters, stripe-bubble transitions accompanied by drastic increases in domain density have been observed when the magnitude of the previously applied perpendicular field Hm is finely tuned throughout the hysteresis loop. Here, we investigate the robustness of these morphological transitions against field sequencing and field cycling. We conducted this study on [Co(x)/Pt(7Å)]N=50 where x varies from 4 to 60 Å. We mapped the morphological transition with Hm varying from 0 to 9 T, following both an ascending sequence (0 → 9 T) and a descending sequence (9 T → 0). We found that the optimal field Hm = H* at which the domain density is maximized and its associated maximal density n* are not significantly affected by the field sequencing direction. We have also investigated possible pumping effects when cycling the applied field at the value H*. We found that n* remains relatively stable through field cycling, and much more stable in the bubble state, compared to longer stripe states. The observed robustness of these morphological transitions against field sequencing and field cycling is of crucial importance for potential magnetic recording applications.
Cell-phone traces reveal infection-associated behavioral change
Authors: Vigfusson Ymir , Karlsson Thorgeir A. , Onken Derek , Song Congzheng , Einarsson Atli F. , Kishore Nishant , Mitchell Rebecca M. , Brooks-Pollock Ellen , Sigmundsdottir Gudrun , Danon Leon 
Published: January 2021

SignificanceInfectious disease control critically depends on surveillance and predictive modeling of outbreaks. We argue that routine mobile-phone use can provide a source of infectious disease information via the measurements of behavioral changes in call-detail records (CDRs) collected for billing. In anonymous CDR metadata linked with individual health information from the A(H1N1)pdm09 outbreak in Iceland, we observe that people moved significantly less and placed fewer, but longer, calls in the few days around diagnosis than normal. These results suggest that disease-transmission models should explicitly consider behavior changes during outbreaks and advance mobile-phone traces as a potential universal data source for such efforts.
SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress
Authors: Ianni Alessandro , Kumari Poonam , Tarighi Shahriar , Simonet Nicolas G. , Popescu Daniela , Guenther Stefan , Hölper Soraya , Schmidt Andreas , Smolka Christian , Yue Shijing , Krüger Marcus , Fiorillo Claudia , Vaquero Alejandro , Bober Eva , Braun Thomas 
Published: January 2021

SignificanceWe discovered that the histone/protein deacetylase SIRT7, which is the only member of the mammalian sirtuin family residing primarily in the nucleolus, stabilizes p53 in response to UV-induced DNA damage by enabling binding of deacetylated NPM to MDM2/HDM2. The study unveils a crucial mechanism by which the nucleolus controls cellular stress responses. Furthermore, it characterizes SIRT7 as a potent regulator of cellular stress and offers opportunities to manipulate cellular p53 levels, which is important for the development of antitumor therapies.
The diversity bonus in pooling local knowledge about complex problems
Authors: Aminpour Payam , Gray Steven A. , Singer Alison , Scyphers Steven B. , Jetter Antonie J. , Jordan Rebecca , Murphy Robert , Grabowski Jonathan H. 
Published: January 2021

Significance
Groups can collectively achieve an augmented cognitive capability that enables them to effectively tackle complex problems. Importantly, researchers have hypothesized that this group property—frequently known as collective intelligence—may be improved in functionally more diverse groups. This paper illustrates the importance of diversity for representing complex interdependencies in a social-ecological system. In an experiment with local stakeholders of a fishery ecosystem, groups with higher diversity—those with well-mixed members from diverse types of stakeholders—collectively produced more complex models of human–environment interactions which were more closely matched scientific expert opinions. These findings have implications for advancing the use of local knowledge in understanding complex sustainability problems, while also promoting the inclusion of diverse stakeholders for increasing management success.
Performance of molecular crystals in conversion of light to mechanical work
Authors: Mahmoud Halabi Jad , Ahmed Ejaz , Sofela Samuel , Naumov Panče 
Published: January 2021

Significance
Over recent years, the increased reporting on mechanically responsive molecular crystals has accumulated an extensive library of organic crystalline materials with diverse nature-like energy-transduction mechanisms. While the chemistry behind the underlying molecular transformations is elaborate, these single crystals' work-producing capacity remains underexplored due to the need for customized testing setups suitable for delicate organic microstructures. Using a simple setup, we lay out a set of performance metrics by which we characterize the light-driven actuation in azobenzene crystals as an exemplary chemical class of dynamic molecular crystals. This work may guide the quantification of responsive molecular crystals' actuation potential and act as an invitation to ramp up interdisciplinary interest to further develop this class of materials into controlled all-organic actuating elements.
Mechanistic basis of propofol-induced disruption of kinesin processivity
Authors: Dutta Mandira , Gilbert Susan P. , Onuchic José N. , Jana Biman 
Published: January 2021

SignificanceKinesins are the major transporters of cargos toward the cell periphery, and their dysfunction leads to a range of human pathologies. Anesthetics used in surgery can shorten the distance that kinesins travel. We show that propofol binds at two crucial sites on the motor domain of the leading head, one at the microtubule interface and the other at the neck-linker region. In both cases, propofol disrupts the order–disorder transition of the neck linkers, resulting in loss of the signal for kinesin to step forward. In contrast, there was not an effect by propofol binding at the trailing head. These results provide a mechanism by which propofol disrupts kinesin stepping, which may diminish their ability to transport critical cargos.
Examining L1 influence in L2 word recognition
Authors: Jiang Nan 
Published: January 2021

Abstract
The present study examined L1 influence in visual L2 word recognition in the area of letter case. Whether an English word
is displayed in upper- or lower-case letters may be of little significance to English native speakers, but many ESL speakers from east Asia
have found it more difficult to recognize words printed in upper-case letters. Two experiments were conducted to explore two questions: (a)
whether there was indeed a case effect in L2 word recognition in that ESL speakers took longer in responding to upper-case words, and (b)
whether this case effect only occurred for ESL speakers whose first languages employed a script other than the Roman alphabet. The
participants included English native speakers, ESL speakers whose L1s employed the Roman alphabet (the Romance ESL group) and ESL speakers
whose L1s did not. They were asked to perform a lexical decision task on English words displayed in either upper- or lower-case letters. In
both experiments, a reliable case effect was found for the latter ESL group only. This L1-related case effect raised both theoretical and
pedagogical issues to be explored in future research.
On nonce echo constructions expressing disapproval and annoyance
Authors: Sánchez Fajardo José A. 
Published: January 2021

Abstract
The aim of this paper is to explore and contrast the morphosyntactic and semantic features of two equivalent nonce echo constructions (NECs) expressing disapproval and annoyance (i.e. don’t (you) X me and ni X ni Y) in colloquial English and Spanish. A NEC is defined as a reactive clause containing duplicated words of the initiative, showing the property of nonceness, and having a communicative goal. Two types of NECs are found in both languages: an attitudinal echo construction and a referential one, the former being more idiomatic than the latter. Based on the premise that texts are necessarily dialogic, two sets of examples are obtained from English corpora (The Movie Corpus, The TV Corpus, and the Corpus of American Soap Operas); and from two Spanish corpora and a dataset (CREA, CORPES XXI, and the Dataset of Spanish Dialogic Texts Online). Findings suggest that both languages show negative and restricted syntactic templates. Variables are coinages that originate from the processes of conversion in English (e.g. don’t you John me) and gender polarity in Spanish (e.g. ni luna ni *luno). Hence, although both types of variables are morphologically novel and contextually meaningful, Spanish variables are generally ungrammatical and unlikely to exist outside the discursive frame under study.
Good response to methotrexate is associated with a decrease in the gene expression of ABCG2, a drug transporter, in patients with rheumatoid arthritis
Authors: Muto Satoshi , Minamitani Nana , Ogura Takehisa , Nakajima Arata , Nakagawa Koichi , Masaka Toru , Hiura Sumiko , Kobayashi Hideki , Kato Hiroyoshi , Kameda Hideto 
Published: January 2021

Abstract

Objectives
Methotrexate (MTX) is used as an anchor drug in the treatment of rheumatoid arthritis (RA), although more than a half of the patients with RA require additional treatments. We designed a prospective study involving two medical centers in Japan to examine the association between the expression of MTX-related genes including a drug transporter ATP-binding cassette sub-family G member 2 (ABCG2) gene and the clinical response to MTX in MTX-naive patients with RA.

Methods
The primary endpoint of this study was good response based on the European League Against Rheumatism (EULAR) response criteria by Disease Activity Score using 28-joint count (DAS28). We evaluated the association between the baseline expression of six genes involved in the intracellular pharmacokinetics of MTX, including ABCG2, as well as their temporal changes, and the clinical response at week 12 from the initiation of MTX.

Results
Based on the clinical response at 12 weeks after the initiation of MTX, 24 patients were classified into good responders (n = 9) and non-good responders (n = 15; 10 moderate responders and 5 non-responders) groups. A univariate logistic regression analysis of the baseline gene expression levels to predict the EULAR good response at week 12 showed a significant association with ABCG2 expression alone. Furthermore, the rate of baseline expression of ABCG2 mRNA above the cut-off value determined using a receiver operating characteristic curve was higher in good responders than in non-good responders (p = .012). Moreover, ABCG2 expression decreased in almost all good responders, but not in non-good responders, after MTX treatment for 12 weeks (median −76% vs. +41% from baseline, respectively; p = .011). The ABCG2 expression level did not correlate with DAS28 at baseline or week 12.

Conclusions
Our study revealed that good response to MTX is associated with a decrease in the expression of ABCG2 in patients with RA.
Sodium bicarbonate supplementation and the female athlete: A brief commentary with small scale systematic review and meta‐analysis
Authors: Saunders Bryan , de Oliveira Luana Farias , Dolan Eimear , Durkalec‐Michalski Krzysztof , McNaughton Lars , Artioli Guilherme Giannini , Swinton Paul Alan 
Published: January 2021

ABSTRACTSodium bicarbonate (SB) is considered an effective ergogenic supplement for improving high‐intensity exercise capacity and performance, although recent data suggests that women may be less amenable to its ergogenic effects than men. Currently, an apparent paucity of data on women means no consensus exists on whether women benefit from SB supplementation. The aim of the current study was to quantify the proportion of the published literature on SB supplementation that includes women, and to synthesise the evidence regarding its effects on blood bicarbonate and exercise performance in women by performing a systematic review and meta‐analysis. Electronic searches of the literature were undertaken using three databases (MEDLINE, Embase, SPORTDiscus) to identify relevant articles. All meta‐analyses were performed within a Bayesian framework. A total of 149 SB articles were identified, 11 of which contained individual group data for women. Results indicated a pooled blood bicarbonate increase of 7.4 [95%CrI: 4.2–10.4 mmol·L−1] following supplementation and a pooled standardised exercise effect size of 0.37 [95%CrI: −0.06–0.92]. The SB literature is skewed, with only 20% (30 studies) of studies employing female participants, of which only 11 studies (7.4%) provided group analyses exclusively in women. Despite the small amount of available data, results are consistent in showing that SB supplementation in women leads to large changes in blood bicarbonate and that there is strong evidence for a positive ergogenic effect on exercise performance that is likely to be small to medium in magnitude.
Highlights
This study aimed to quantify the proportion of the published literature on sodium bicarbonate supplementation that includes women and to synthesise the evidence regarding its ergogenic effect on women, using a systematic review and meta‐analytic approach.
The sodium bicarbonate literature is skewed, with only 30 studies (20%) employing female participants, of which only 11 studies (7.4%) provided group analyses exclusively in women.
Despite the small amount of available data, results are consistent in showing that sodium bicarbonate supplementation in women leads to large changes in blood bicarbonate and that there is strong evidence for a positive ergogenic effect on exercise performance that is likely small to medium in magnitude.
Based on these findings, we do not believe there is any evidence to support sex‐specific sodium bicarbonate dosing recommendations and that current recommendations of 0.2–0.3 g·kg−1BM of SB taken 60–180 min prior to high‐intensity exercise appear appropriate for the female athlete.
Arthrogenic muscle inhibition and return to sport after arthrofibrosis complicating anterior cruciate ligament surgery
Authors: Dauty Marc , Menu Pierre , Mesland Olivier , Fouasson‐Chailloux Alban 
Published: January 2021

ABSTRACTArthrofibrosis is a devastating complication after Anterior Cruciate Ligament reconstruction (ACLr) characterized by a muscle weakness secondary to an arthrogenic muscle inhibition process. The loss of knee isokinetic strength due to arthrogenic muscle inhibition may be more important after arthrofibrosis, compared to an ACLr population with no complication. The isokinetic strength deficit [Limb Symmetry Index (LSI) at 60 and 180°/s of angular speed] was measured at 4, 7 and 12 post‐operative months. Knee function, return to running and return to sport were evaluated. A comparison of the Quadriceps and the Hamstring LSI between patients with arthrofibrosis and those without post‐operative complication was performed according to time and taking into consideration the type of surgical procedure. 539 primary ACLr patients were assessed. The arthrofibrosis group presented at 4, 7 and 12 post‐operative months a Quadriceps LSI significantly lower compared to the control group, without influence of the graft procedure (LSI: 38, 53, 68% vs 63, 73, 85% at 60°/s, respectively). The Hamstring LSI was significantly lower at 4 and 7 post‐operative months, but comparable at 12 months with an influence of the Hamstring procedure. Knee function was significantly lower at 4 and 7 post‐operative months. Few arthrofibrosis ACLr patients returned to running at 7 post‐operative months (6.8% vs 69.9%; p < .0001). An important and durable Quadriceps muscle weakness occurred after arthrofibrosis, whatever the type of graft procedure. This is explained by an Arthrogenic muscle inhibition which compromised the return to sport at the same level until 12 post‐operative months.Highlights
An important and durable quadriceps muscle weakness occurred after arthrofibrosis.
The arthrogenic muscle inhibition was significant on the operated side independently of the type of the graft procedure.
Arthrogenic muscle inhibition compromised the return to sport at the same level until 12 post‐operative months.
Einstein’s time dilation and the relativistic Doppler shift: avoiding the pitfalls
Authors: Ataman S 
Published: January 2021

Abstract
Introductory textbooks for the theory of special relativity discuss the time dilation effect after introducing the Lorentz transformations. Reading the dictum ‘moving clocks run slow’ a student is likely to have the impression that this is a measured effect. On the other hand, after considering the relativistic Doppler effect the same student might be puzzled that this effect depends on the relative emitter-observer direction, contrary to Einstein’s time dilation. Simple thought experiments are presented here where the inferred time dilation and the observed relativistic Doppler effect give quite opposite answers. Before solving the puzzle, we show how easily one can get confused and obtain apparently contradictory results.
Numerical analysis of nitrogen fixation by nanosecond pulse plasma
Authors: Cheng He , Li Yiqian , Zheng Kuanlei , Liu Dawei , Lu Xinpei 
Published: January 2021

Abstract
Nonthermal plasma (NTP) provides a novel approach to developing renewable and efficient nitrogen fixation (NF) technology. However, the efficiency optimization of NTP-assisted NF (NTP-NF) remains challenging due to the elusive ultra-fast plasma process, especially in packed-bed dielectric barrier discharge (PB-DBD). Our work presents a unique view on how to optimize the efficiency of NTP-NF based on precise studies of plasma dynamics and chemistry by developing a novel nanosecond pulse driving PB-DBD model. 2D plasma dynamics show that the plasma propagates in the form of surface ionization waves coupled with filamentary micro-discharge. Electron heating by high instantaneously applied power determines the development of ionization waves and NO production. Plasma chemistry shows that selectively enhancing the energy of electronically excited dissociation to produce N* is the most efficient way to increase the production of NO.
Impact of the protein composition on the structure and viscoelasticity of polymer-like gluten gels
Authors: Ramos Laurence , Banc Amélie , Louhichi Ameur , Pincemaille Justine , Jestin Jacques , Fu Zhendong , Appavou Marie-Sousai , Menut Paul , Morel Marie-Hélène 
Published: January 2021

Abstract
We investigate the structure of gluten polymer-like gels in a binary mixture of water/ethanol, 50/50 v/v, a good solvent for gluten proteins. Gluten comprises two main families of proteins, monomeric gliadins and polymer glutenins. In the semi-dilute regime, scattering experiments highlight two classes of behavior, akin to standard polymer solution and polymer gel, depending on the protein composition. We demonstrate that these two classes are encoded in the structural features of the proteins in very dilute solution, and are correlated with the presence of proteins assemblies of typical size tens of nanometers. The assemblies only exist when the protein mixture is sufficiently enriched in glutenins. They are found directly associated to the presence in the gel of domains enriched in non-exchangeable H-bonds and of size comparable to that of the protein assemblies. The domains are probed in neutron scattering experiments thanks to their unique contrast. We show that the sample visco-elasticity is also directly correlated to the quantity of domains enriched in H-bonds, showing the key role of H-bonds in ruling the visco-elasticity of polymer gluten gels.