bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remdesivir Efficacy in COVID-19 Treatment: A Randomized Controlled Trial
Authors: Abd-Elsalam Sherief , Ahmed Ossama Ashraf , Mansour Noha O. , Abdelaziz Doaa H. , Salama Marwa , Fouad Mohamed Hassan Ahmed , Soliman Shaimaa , Naguib Ahmed Mohamed , Hantera Mohamed Sayed , Ibrahim Ibrahim S. , Torky Mohamed , Dabbous Hany M. , El Ghafar Mohamed Samir Abd , Abdul-Baki Enas A. , Elhendawy Mohammed 
Published: September 2021

To date, no antiviral therapy has shown proven clinical effectiveness in treating patients with COVID-19. We assessed the efficacy of remdesivir in hospitalized Egyptian patients with COVID-19. Patients were randomly assigned at a 1:1 ratio to receive either remdesivir (200 mg on the first day followed by 100 mg daily for the next 9 days intravenously infused over 30–60 minutes) in addition to standard care or standard care alone. The primary outcomes were the length of hospital stay and mortality rate. The need for mechanical ventilation was assessed as a secondary outcome. Two hundred patients (100 in each group) completed the study and were included in the final analysis. The remdesivir group showed a significantly lower median duration of hospital stay (10 days) than the control group (16 days; P < 0.001). Eleven of the patients in the remdesivir group needed mechanical ventilation compared with eight patients in the control group (P = 0.469). The mortality rate was comparable between the two groups (P = 0.602). Mortality was significantly associated with older age, elevated C-reactive protein levels, elevated D-dimer, and the need for mechanical ventilation (P = 0.039, 0.003, 0.001, and < 0.001 respectively). Remdesivir had a positive influence on length of hospital stay, but it had no mortality benefit in Egyptian patients with COVID-19. Its use, in addition to standard care including dexamethasone, should be considered, particularly in low- and middle-income countries when other effective options are scarce.
The Occurrence of Different Vertical Jump Types in Basketball Competition and their Relationship with Lower-Body Speed-Strength Qualities.
Authors: Talpey Scott , Smyth Andrew , O'Grady Mathew , Morrison Matthew , Young Warren 
Published: September 2021

Jumps occur frequently in basketball and can be executed from a single-leg take-off following a run-up or bilaterally from a standing start. Understanding the type of jumps performed in competition and how different muscular qualities influence their performance, informs training prescription. Firstly, to quantify the occurrence of different jump types performed in competition an analysis of 15 semi-professional basketball games was undertaken. Secondly, to understand the influence of muscular qualities on performance of different jump types, Semi-professional male basketball players (N=17) performed jump tests; standing vertical jump, running vertical jumps with a double leg take-off (RVJ2) and a single leg take-off (RVJ1) and tests of lower-body speed-strength; reactive strength index (RSI) from a drop jump, counter movement jump (CMJ) and squat jump. A stationary approach was employed for 69%, a running approach for 26% and a one-step approach for 5%. RVJ1 displayed non-significant (P=0.07) moderate correlation with jump height attained from the CMJ (r=0.439) and a very large (r =.806) significant (P<0.01) correlation with RSI. Most jumps were executed from a stationary start with a bilateral take-off while a run-up occurred prior to a substantial proportion of jumps. Jumps with a single-leg take-off from a run-up strongly correlate with RSI.
Sistem Pendukung Keputusan Dalam Pemilihan Biji Kelapa Sawit Menggunakan Metode MOORA
Authors: Sinon Inne Irianti , Rozi Anief Fauzan 
Published: September 2021

Kelapa sawit merupakan jenis tumbuhan yang termasuk dalam keluarga tumbuhan genus elais dan arecaceae. Tumbuhan kelapa sawit banyak di tanam di Indonesia yang seb tropis. Buah kelapa sawit sendiri di fungsikan untuk diambil buahnya yang mana berfungsi sebagai bahan baku utama pembuatan minyak kelapa sawit. untuk mendapatkan hasil panen yang maksimal maka para pelaku usaha wajib memilih biji kelapa sawit terbaik, agar nantinya hasil panen yang ditentukan juga akan lebih maksimal.
Berdasarakan pembahasan diatas maka didapat kan suatu masalah yaitu dalam pemilihan biji kelapa sawit yang terbaik. Berdasarkan masalah tersebut maka dibutuhkan suatu sistem informasi pendukung keputusan yang mana akan menghasilkan suatu output rekomendasi keputusan dalam pemilihan biji kelapa sawit terbaik. Dengan demikian dapat diusulkan pembuatan susatu sistem pendukung keputusan pemilihan biji kelapa sawit yang mana dalam proses perhitungannya menggunakan metode MOORA. Dari hasil uji yang dilakukan dari 5 alternatif didapatkan hasil Biji Kelapa Sawit Grad A memiliki nilai tertinggi yaitu dengan nilai 31,87.
Hubungan Faktor Guru dan Persekitaran dengan Pembelajaran Pendidikan Jasmani : Satu Tinjauan di Sekolah Menengah Pendalaman Sabah
Authors: Rahman Ahmad Fadly Abdul , Taat Muhamad Suhaimi , Hongkong Jenorita 
Published: September 2021

Kajian ini bertujuan untuk mengenal pasti hubungan faktor guru dan persekitaran dengan pembelajaran Pendidikan Jasmani di Sekolah Menengah. Kajian ini berbentuk kuantitatif bukan eksperimen dengan menggunakan kaedah tinjauan untuk menjawab objektif kajian. Seramai 101 orang murid telah dipilih secara rawak dari 4 buah sekolah menengah. Kajian ini menggunakan instrumen soal selidik yang diadaptasi daripada “School-Level Environment Questionnaire” untuk mengukur faktor guru dan persekitaran sekolah dan soal selidik “National Survey of Student Engagement” untuk mengukur penglibatan pelajar dalam pembelajaran Pendidikan Jasmani. Dapatan kajian mendapati tidak terdapat perbezaan faktor guru dan persekitaran berdasarkan jantina lelaki dan wanita. Selain itu, dapatan kajian menunjukkan terdapat hubungan yang signifikan antara faktor guru dengan pembelajaran Pendidikan Jasmani (r=.868, p<0.01), dan faktor persekitaran dengan pembelajaran Pendidikan Jasmani (r=.907, p<0.01). Dapatan kajian menunjukkan bahawa faktor guru dan faktor persekitaran adalah pemboleh ubah yang relevan bagi meningkatkan penglibatan pelajar dalam pembelajaran Pendidikan Jasmani di Sekolah Menengah di Dearah Pendalaman. Oleh yang demikian, pihak sekolah perlu menitik beratkan faktor guru dan persekitaran kerana ianya memberi kesan kepada penglibatan pelajar dalam aktiviti pembelajaran Pendidikan Jasmani di sekolah. Semua pihak perlu berusaha memperbaiki dan mempertingkatkan kebolehan mengajar, mempunyai pengetahuan yang spesifik dalam bidang pembelajaran serta menambaik persekitaran sekolah supaya dapat mempengaruhi penglibatan pelajar dalam pembelajaran pendidikan jasmani ke arah yang lebih baik.
PENGETAHUAN DAN TINDAKAN PERSONAL HYGIENE SAAT MENSTRUASI PADA REMAJA
Authors: Purnama Ni Luh Agustini 
Published: September 2021

Perawatan saat menstruasi perlu dilakukan karea jika kurang dijaga kebersihannya akan berpotensi terhadap timbulnya infeksi pada organ reproduksi. Dalam meningkatkan kebersihan organ reproduksi dan pencegahan penyakit, diharapkan untuk wanita memiliki pengetahuan yang baik sehingga dapat berpengaruh pada kebiasaan positif. Tujuan dari penelitian ini adalah mengidentifikasi hubungan antara tingkat pengetahuan dengan tindakan personal hygiene menstruasi remaja putri. Desain penelitian menggunakan cross sectional. Responden sebanyak 42 remaja putri di SMKN 4 Negara yang diambil dengan teknik simple random sampling. Pengetahuan dan praktik diukur dengan menggunakan kuesioner. Uji statistik yang digunakan dalam penelitian ini dengan uji Spearman. Dari dari 35 reponden yang berpengetahuan baik sebanyak 55 (94,3%) tindakan personal hygiene saat menstruasinya dalam kategori baik. Hanya 1 responden yang memiliki pengetahuan ketegori kurang dengan tindakan personal hygiene yang tidak baik . Hasil Uji Rank Spearman menunjukkan nilai p< 0,05 artinya ada hubungan pengetahuan dengan tindakan personal hygiene saat mentruasinya. Nilai korelasi rho yaitu 0,47 hal ini arah hubungan positif dan kekuatan hubungan sedang. Arah hubungan positif artinya semakin tinggi skor pengetahuan maka semakin baik tindakan personal hygiene
Security management of national park security in the border of Indonesia - Malaysia
Authors: Saptono Edy , Keiza Ribka , Wijayanto Joni 
Published: September 2021

Boundary is an important part of the state's sovereignty and becomes a fortress of all kinds of threats. The threat about security of natural resources is one of non-military threat which affects Indonesia’s security. Betung Kerihun National Park adjoins to Malaysia in northern of Indonesia, so it can be vulnerable to threats. The purposes of this research are to analyze the threat of security toward management of Betung Kerihun National Park (TNBK), the efforts made to overcome the security threat, and the management of TNBK on the border of Indonesia and Malaysia. The research uses qualitative method using in-depth interviews and later analyzing the primary and secondary data. The results show that the security threats of TNBK are agarwood stealing, gold mining, illegal logging, wildlife distribution, lack of security staff, no security forces (Satgas Pamtas) on the northern boundary of TNBK, and border patrol inspection line construction. The efforts to overcome security threats are preventive, pre-emptive, and repressive. The management of TNBK on the border of Indonesia and Malaysia in order to protect border security are including management functions of planning, organizing, leading (directing), and evaluating. The recommendations to overcome the security threat of national parks on the border between Indonesia and Malaysia are the active role of security forces and the establishment of buffer zone management.
Michael Chekhov’s Acting Technique
Authors: Rushe Sinéad 
Published: September 2021

Intended for actors, directors, teachers and researchers, this book offers an exceptionally clear and thorough introduction to the renowned acting technique developed by Michael Chekhov. Sinéad Rushe’s book provides a complete overview of the whole method, and includes illuminating explanations of its principles, as well as a wide range of practical exercises that illustrate, step by step, how they can be applied to dramatic texts.
Part One provides an outline of the ideas that underpin the work, which help to prepare practitioners to become responsive and receptive, and to awaken their imagination. Part Two charts a journey through the foundational psychophysical exercises that can both orient an actor's training routine and be applied directly to the development of a role. Part Three focuses on more specific and elaborate methods of scene work, characterisation and the art of transformation.
Drawing on the full range of Chekhov's writing in English and French, this book also examines unpublished material from the Dartington Hall archives and features interviews with actors who have worked with the technique, including Simon Callow and Joanna Merlin. It illustrates Chekhov’s approach by referring to Rushe's own productions of Nikolai Gogol's short story Diary of a Madman and Shakespeare's Othello, as well as characters and scenes in Sarah Kane's Blasted and the contemporary American television series Breaking Bad.
Michael Chekhov’s Acting Technique is an accessible, comprehensive and contemporary point of reference for those already trained in the method, as well as an initiation and toolkit for practitioners who are just beginning to discover it.
The Impact of Construction Labour Productivity on the Renovation Wave
Authors: Wandahl Soren , Pérez Christina T. , Salling Stephanie , Neve Hasse H. , Lerche Jon , Petersen Steffen 
Published: September 2021

The European Green Deal's Renovation Wave aims to renovate 35 million energy-inefficient buildings to reduce carbon dioxide (CO2) emissions by at least 55% by 2030. Historically, efforts to reduce CO2 emissions focused on Operational Energy (OE) of the finished buildings. However, in recent years the Embodied Energy (EE) of the building’s construction process has gained attention because of its essential role in construction renovations projects. In this context, construction efficiency, and more precisely, workers’ efficiency, is a vital catalyst to achieve the European Union (EU) targets. To identify the impact of Construction Labour Productivity (CLP) on the renovation wave an exploratory case study was adopted as a research strategy. Data from four domestic housing renovation projects were gathered. Three specific research goals are outlined. The first is to demonstrate the effect of the adoption of Lean tools and methods to increase CLP. The second is to quantify the correlation between improved productivity and the EE emissions saved during the construction phase. The third goal is to estimate the effect the higher productivity has on OE emissions. The results show that the adoption of several Lean tools and methods has a potential to improve CLP to 45%. This rate of improvement for the 35 million housing units to be renovated could save 6.9 million tonnes CO2e from EE and 386 million tonnes CO2e from OE. This novelty link between process improvements and reduced energy consumption and emissions can support politicians and infrastructural developers in decision-making for a more sustainable construction industry.
The Brewer–Dobson circulation in CMIP6
Authors: Abalos Marta , Calvo Natalia , Benito-Barca Samuel , Garny Hella , Hardiman Steven C. , Lin Pu , Andrews Martin B. , Butchart Neal , Garcia Rolando , Orbe Clara , Saint-Martin David , Watanabe Shingo , Yoshida Kohei 
Published: September 2021

Abstract. The Brewer–Dobson circulation (BDC) is a key feature of the stratosphere that models need to accurately represent in order to simulate surface climate variability and change adequately. For the first time, the Climate Model Intercomparison Project includes in its phase 6 (CMIP6) a set of diagnostics that allow for careful evaluation of the BDC. Here, the BDC is evaluated against observations and reanalyses using historical simulations. CMIP6 results confirm the well-known inconsistency in the sign of BDC trends between observations and models in the middle and upper stratosphere. Nevertheless, the large uncertainty in the observational trend estimates opens the door to compatibility. In particular, when accounting for the limited sampling of the observations, model and observational trend error bars overlap in 40 % of the simulations with available output. The increasing CO2 simulations feature an acceleration of the BDC but reveal a large spread in the middle-to-upper stratospheric trends, possibly related to the parameterized gravity wave forcing. The very close connection between the shallow branch of the residual circulation and surface temperature is highlighted, which is absent in the deep branch. The trends in mean age of air are shown to be more robust throughout the stratosphere than those in the residual circulation.
Orientation selective grain sublimation–deposition in snow under temperature gradient metamorphism observed with diffraction contrast tomography
Authors: Granger Rémi , Flin Frédéric , Ludwig Wolfgang , Hammad Ismail , Geindreau Christian 
Published: September 2021

Abstract. In this study on temperature gradient metamorphism in snow, we investigate the hypothesis that there exists a favourable crystalline orientation relative to the temperature gradient, giving rise to a faster formation of crystallographic facets.
We applied in situ time-lapse diffraction contrast tomography on a snow sample with a density of 476 kg m−3 subject to a temperature gradient of 52 ∘Cm-1 at mean temperatures in the range between −4.1 and −2.1 ∘C for 3 d. The orientations of about 900 grains along with their microstructural evolution are followed over time.
Faceted crystals appear during the evolution, and from the analysis of the material fluxes, we observe higher sublimation–deposition rates for grains with their c axis in the horizontal plane at the beginning of the metamorphism. This remains the case up to the end of the experiment for what concerns sublimation while the differences vanish for deposition. The latter observation is explained in terms of geometrical interactions between grains.
Lakóotthonban élő értelmileg akadályozott személyek és segítőik nonverbális kommunikációjának jellegzetességei
Authors: Bényi Eszter , Barthel Betty , Galgóczy Anna 
Published: September 2021

Módszer: Jelen munkánk esettanulmány, egy adott lakóközösség 4 tagjának megadott időszakokban – a közös vacsora előkészítése és elköltése során – videóval rögzített nonverbális kommunikációs megnyilvánulásainak kvalitatív és kvantitatív elemzése. Megfigyeltük a lakók[1] egymás felé irányuló, valamint két eltérő kommunikációs stílusú segítővel[2] megvalósuló interakcióit. Mivel a lakóközösség hagyományai közt szerepel a „csendes vacsora” – ekkor nem történik verbális megnyilatkozás –, a „beszélgetős” és „csendes” alkalmakkor jellemző nonverbális megnyilatkozások egybevetésére is sor került.
Eredmények: Az értést támogató illusztráló gesztusokat (Wacha, 2011) a lakók leginkább az önkifejezésre használják. Az irányító gesztusok vonatkozásában kapott eredmények megerősítik a szakirodalmakban (pl. Hódi, 1981) leírtakat, miszerint leginkább a domináns fél használja ezen jelzéseket. Az önmagát nehezen kifejező értelmileg akadályozott személy a feszültséggel teli helyzetekben szorongással reagálhat, ami testet ölthet a gesztikulációban is. A Horányi-féle participatív modellben értelmezve (Horányi, 2006) a lakók és a segítők közötti eltérő kommunikációs szubkultúrához tartozásból fakadó szakadék áthidalásához a lakók számára eszközként szolgálhatnak az illusztráló gesztusok.
Következtetések: Az értelmileg akadályozott személyeket támogató neurotipikus emberek jelentős hatással vannak a támogatott emberek kommunikációs szerepbetöltésére, valamint az interakcióik tartalmi és dinamikai aspektusaira. Ebből kifolyólag elengedhetetlen a segítő személyek tudatos háttérbe húzódása, valamint a szimmetrikus kommunikációs helyzetek megteremtése.
Kulcsszavak: értelmi akadályozottság, felnőtt, nonverbális kommunikáció, gesztikuláció, lakóotthon.
[1] A vizsgálati helyszínül szolgáló lakóotthonban élő, értelmileg akadályozott személyek.
[2] A lakóotthon közösségének azon neurotipikus tagja, aki az értelmileg akadályozott személyeket a mindennapi helyzetekben, feladatokban támogatja.
Deserción académica universitaria y aislamiento preventivo obligatorio en Colombia: Estudio “CHEMA - COVID-19”
Authors: Chaves Campo Carlos Felipe , Muñoz Bonilla Hugo Alejandro , González Guacaneme Gladys 
Published: September 2021

El estudio CHEMA - COVID-19 permite establecer cómo la intención de persistencia académica de los estudiantes de una universidad estaba relacionada con los cambios en los hábitos de estudio y motivaciones de aprendizaje (CHEMA) presentados durante el aislamiento preventivo obligatorio (APO) vivido en Colombia, a raíz de la pandemia COVID-19. Es una investigación de alcance correlacional longitudinal y descriptivo, con muestra probabilística de panel fijo, que identifica los factores ambientales de aprendizaje del educando, la metodología adoptada por los docentes y las acciones institucionales, en una correlación positiva con la decisión de continuidad académica. Los resultados contribuyen a estimar una tasa de deserción para el segundo semestre del año 2020, e identificar su comportamiento desagregado en la población educativa y otras variables intervinientes.
Correlation between p53 expression
and hepatocellular carcinoma
differentiation grade
Authors: Issamatov B. K. , Yenin E. A. , Medeubekov U. Sh. , Baymakhanov B. B. 
Published: September 2021

Relevance: Hepatocellular carcinoma (HCC) is one of
the world’s most common liver cancers and fatal malignant neoplasms. According to GLOBOCAN 2018, liver cancer ranks sixth in incidence (842,000 new cases) and fourth
in mortality (782,000 deaths) globally. In Kazakhstan, there
is an increase in HCC incidence from 879 cases in 2016 up to
984 cases in 2017, which amounted to 5.5 cases per 100 000
population. In 2017, the five-year survival rate was 23.7%.
The mutations in the p53 gene that encodes the p53
protein are most frequent in HCC (35.2%). A high level of
nuclear expression of p53 and a decrease in apoptosis of tumor cells with a simultaneous increase in their proliferative
activity, noted in HCC cells, are important for the prognosis
of the disease. There is a correlation between poor prognosis, a decreased survival of patients with HCC, and high
expression of the p53 oncoprotein in HCC.
U. Nzeako et al. have revealed a strong correlation of
HCC histological differentiation with the patient survival
rate. Therefore, a study of the correlation between p53 expression and HCC differentiation grade is very relevant.
The purpose of this study was to analyze the correlation between p53 expression and HCC differentiation
grade.
Results: p53 was overexpressed in 18% of HCC cases;
the expression was high in 62% and low in 20% of HCC
cases. In well-differentiated HCC (G1), the p53-immunopositive nuclei expression was low in 10 cases and high
in 2 cases. In moderately differentiated HCC (G2), p53 was
highly expressed in 21 cases and overexpressed in 2 cases.
In low-differentiated HCC (G3), p53 was overexpressed in 7
cases and highly expressed in 8 cases of HCC. The analysis
of the correlation between p53 expression and HCC differentiation grade by Spearman showed a high correlation
(r=0.79, p<0.01), evidencing a direct dependence of p53
expression level on HCC gradation.
Conclusion: HCC differentiation grade highly correlates with p53 expression level in immunopositive nuclei
of HCC cells. The obtained data evidences a dependence
between p53 expression level and HCC gradation.
Olfactory neuroblastoma
Authors: Zhetpisbaev B. B. , Satbaeva E. B. , Ryskeldiev N. A. , Ashirov N. N. , Gorshkova E. S. 
Published: September 2021

The article describes a classical case of olfactory neuroblastoma in a 33-year-old female patient diagnosed with
«nasal cavity neoplasm (polyp?)» who was referred to the National Centre for Neurosurgery JSC from the ENT Department
of the City Hospital No. 1. The first symptoms of the tumor occurred during her pregnancy. The aggressive tumor has invaded the anterior cranial fossa and spread into the right half of
the ethmoid sinuses and the orbit. The tumor diagnostics was
complicated by the prevalence of symptoms of a nasal cavity
neoplasm. The “olfactory neuroblastoma” diagnosis was verified by clinical observations, MRI, and pathomorphological
studies. Histological examination of the tumor showed a typical structure of olfactory neuroblastoma. IHC examination
showed an expression of neuronal differentiation markers.
The degree of malignancy was determined by Hyams grade
To the history of the study of malignant
tumors and the organization of cancer
service in Kazakhstan
Authors: Dynyak А. К. 
Published: September 2021

Relevance: Ivan Petrovich Pavlov once said, «Never grasp
the next without mastering the previous.» Current scientific
studies on cancer, and not only cancer, make little use of the
historical method. However, the analysis of an issue in the
dynamics of historical development contributes to better understanding and making sound decisions. The materials on
morbidity, mortality, the history of cancer research, and the
development of the cancer service in Kazakhstan contribute
to the formation of historical thinking and erudition.
The purpose of the study was to analyze the cancer
incidence in Kazakhstan based on the materials of scientific
works of N.F. Kramchaninov of 1960-1970s and to uncover
the directions and results relevant today.
Results: Kazakhstani scientists have actively and fruitfully participated in the study of cancer epidemiology, etiology, pathogenesis, and prevention. Cancer diseases have
been reported starting from the XIX century, with a constant
growth trend. The role of UV rays in skin cancer etiology
was studied for a long time and in detail; specific preventive
measures were proposed.
Conclusion: The results obtained by researchers of past
years deserve a thorough analysis, use in current conditions,
and further research.