bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcortical brain structure in children with developmental coordination disorder: A T1-weighted volumetric study
Authors: Grohs Melody N. , Lebel Catherine , Carlson Helen L. , Craig Brandon T. , Dewey Deborah 
Published: August 2021

AbstractDevelopmental coordination disorder (DCD) is a neurodevelopmental disorder occurring in 5–6% of school-aged children. Converging evidence suggests that dysfunction within cortico-striatal and cortico-cerebellar networks may contribute to motor deficits in DCD, yet limited research has examined the brain morphology of these regions. Using T1-weighted magnetic resonance imaging the current study investigated cortical and subcortical volumes in 37 children with DCD, aged 8 to 12 years, and 48 controls of a similar age. Regional brain volumes of the thalamus, basal ganglia, cerebellum and primary motor and sensory cortices were extracted using the FreeSurfer recon-all pipeline and compared between groups. Reduced volumes within both the left and right pallidum (Left: F = 4.43,p = 0.039; Right: F = 5.24,p = 0.025) were observed in children with DCD; however, these results did not withstand correction for multiple comparisons. These findings provide preliminary evidence of altered subcortical brain structure in DCD. Future studies that examine the morphology of these subcortical regions are highly encouraged in order replicate these findings.
Management of Laryngotracheal Stenosis in Obesity. Is This Another Co-morbidity that Can Be Improved with Weight Loss Following Bariatric Surgery?
Authors: Fehervari Matyas , Patel Shivali , Towning Rebecca , Haire Kevin , Al Yaghchi Chadwan , Sabharwal Atika , Sandhu Guri , Efthimiou Evangelos 
Published: August 2021

Abstract
Purpose
Bariatric surgery improves several obesity-related comorbidities. Laryngotracheal stenosis is a rare condition that is usually managed with repeated endoscopic airway interventions and reconstructive airway surgery. The outcome of these definitive operations is worse in individuals with obesity. There are no studies investigating the effect of weight loss following bariatric surgery in the management of laryngotracheal stenosis.

Materials and Methods
In an observational study, consecutive patients with a BMI over 35 kg/m2 and laryngotracheal stenosis were prospectively recruited to a bariatric and airway stenosis database in two tertiary care centres. Patients were treated with laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy and control subjects were managed conservatively.

Results
A total of eleven patients with an initial body mass index of 43 kg/m2 (37–45) were enrolled to this study. Six patients underwent bariatric surgery and five subjects were treated conservatively. After 12 months, the total weight loss of patients undergoing bariatric surgery was 19.4% (14–24%) whilst 2.3% (1–3%) in the control group. The annual number of endoscopic airway interventions following bariatric surgery reduced (p = 0.002). Higher weight loss in patients led to less frequent interventions compared to control subjects (p = 0.004). Patients undergoing laryngotracheal reconstruction following bariatric surgery needed less endoscopic intervention, an annual average of 1.9 interventions before vs 0.5 intervention after. Conservatively managed control subjects required more frequent endoscopic intervention, 1.8 before vs 3.4 after airway reconstruction.

Conclusion
Bariatric surgery reduced the number of endoscopic airway interventions and enabled patients to undergo successful definitive airway reconstructive surgery.
Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients
Authors: Courelli Vasiliki , Ahmad Alla , Ghassemian Majid , Pruitt Chris , Mills Paul J. , Schmid-Schönbein Geert W. 
Published: August 2021

AbstractIntroductionHeart failure is associated with degradation of cell functions and extracellular matrix proteins, but the trigger mechanisms are uncertain. Our recent evidence shows that active digestive enzymes can leak out of the small intestine into the systemic circulation and cause cell dysfunctions and organ failure.MethodsAccordingly, we investigated in morning fasting plasma of heart failure (HF) patients the presence of pancreatic trypsin, a major enzyme responsible for digestion.ResultsWestern analysis shows that trypsin in plasma is significantly elevated in HF compared to matched controls and their concentrations correlate with the cardiac dysfunction biomarker BNP and inflammatory biomarkers CRP and TNF-α. The plasma trypsin levels in HF are accompanied by elevated pancreatic lipase concentrations. The trypsin has a significantly elevated activity as determined by substrate cleavage. Mass spectrometry shows that the number of plasma proteins in the HF patients is similar to controls while the number of peptides was increased about 20% in HF patients. The peptides are derived from extracellular and intracellular protein sources and exhibit cleavage sites by trypsin as well as other degrading proteases (data are availableviaProteomeXchange with identifier PXD026332).ConnclusionsThese results provide the first evidence that active digestive enzymes leak into the systemic circulation and may participate in myocardial cell dysfunctions and tissue destruction in HF patients.ConclusionsThese results provide the first evidence that active digestive enzymes leak into the systemic circulation and may participate in myocardial cell dysfunctions and tissue destruction in HF patients.
The effects of language on patience: an experimental replication study of the linguistic-savings hypothesis in Austria
Authors: Angerer Silvia , Glätzle-Rützler Daniela , Lergetporer Philipp , Sutter Matthias 
Published: August 2021

AbstractThe famous linguistic-savings hypothesis states that languages that grammatically separate the future from the present (like English) causally induce less future-oriented behavior than languages in which speakers can refer to the future using present tense (like German or Chinese). Chen et al., European Economic Review 120 (2019) experimentally investigate the effect of using future-oriented language on incentivized intertemporal choices and find no support for the hypothesis. We replicate Chen et al., European Economic Review 120 (2019)’s study in the German-speaking context. In our experiment with 332 subjects, we randomly refer to future payments using present or future tense and find no causal effect of language on intertemporal choice. Given the importance of replications for confidence in scientific findings, our results provide corroborating evidence that the linguistic-savings hypothesis is not empirically tenable. Eventually, the results provide a methodological contribution to the conduct of experiments.
Nonlinear vibration of the spiral bevel gear under periodic torque considering multiple elastic deformation evaluations due to different bearing supports
Authors: Samani Farhad S. , Salajegheh Moein , Molaie Moslem 
Published: August 2021

Abstract
This paper investigates two parameters effect on vibrational responses of the spiral bevel gear. Changing the gear system overall stiffness (GSOS) considering elastic deformation and periodic torques are the two parameters which are represented as the main goals of this study. In order to investigate the effects of shaft stiffness and elastic deformation, two different cases with different support locations are considered. The first case is presented by locating the support close to the gear, and in the latter one, the distance between gear and support is increased. Besides, to study the effect of torque, two main types are considered: constant and periodic excitation torque. To illustrate the dynamic behavior, the governing differential equations are solved numerically according to the Runge–Kutta method. The equations are nonlinear due to backlash and time-varying coefficients as the results of GSOS variation. Vibrational phenomena are illustrated by means of bifurcation diagrams, RMS, and Poincaré maps. Particular vibrational behaviors such as “chaos” and “period-doubling” phenomena are illustrated with details. By investigating the effect of shaft stiffness, results show that when the support is far away from gear, the vibration response increased by 67.5%. Moreover, while the input torque is constant, the support movement does not cause undesirable responses such as chaotic or period-doubling responses. The periodic torque causes undesirable responses such as chaos and bifurcation and period-doubling responses.

Article Highlights
What is done in the present paper can be mentioned in three main parts:

The nonlinear dynamics of the spiral bevel gear pair under two different support situations is investigated in this paper.

To scrutinize the dynamic behavior of the spiral bevel gear-pair in a nearly real situation, the input driver torque is periodically variable.

The results show that the spiral bevel gear pair may comprise chaotic response with periodic torque excitation if the bearing supports locate far enough from the gears.
Bulking Based Porosity Method to Predict Floodable Volume of Longwall Gob
Authors: Silvis Joshua M. , Hasenfus Greg J. , Haines Allison M. 
Published: August 2021

AbstractThe floodable volume of longwall gob can be of great importance in developing accurate coal mine operation plans, particularly for mine water management and environmental control strategies. Given the inaccessibility and difficulty in direct measurement of gob characteristics following gob recompression, hydrologic, geomechanical, and spatial data and principles were used to solve for the porosity and height of the residual gob using a mathematical model framework and bulking-based techniques. Based on this approach, gob porosity of Appalachian longwalls appears to be tighter than previously reported, ranging between 4.99 and 14.31%. Residual gob height, as normalized with respect to mine extraction height, ranges between 1.90 and 2.45. A novel, bedding-based bulking approach is ampliative with respect to existing roof caving and bulking fundamentals, as it has greater explanatory value compared with the traditional, lithologic-based bulking application. The efficacy of using the residual gob characteristics determined by the mathematical model and bedding-based bulking is examined using a causal comparative method, whereby time series prediction of historical groundwater rebound is compared with observed mine pool elevation data. Prediction accuracy is significantly improved using a prototype model to calculate void volume of longwall gob, specifically, the dependence of porosity of the gob material upon the longwall width to overburden depth ratio for movement basins of subcritical and critical panel widths. The potential implication of these findings toward hydrologic, geomechanical, and ventilation studies of longwall gob could be significant.
The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types
Authors: Chen Tingting , Chen Xu , Zhang Sisi , Zhu Junwei , Tang Bixia , Wang Anke , Dong Lili , Zhang Zhewen , Yu Caixia , Sun Yanling , Chi Lianjiang , Chen Huanxin , Zhai Shuang , Sun Yubin , Lan Li , Zhang Xin , Xiao Jingfa , Bao Yiming , Wang Yanqing , Zhang Zhang , Zhao Wenming 
Published: August 2021

Abstract
The Genome Sequence Archive (GSA) is a data repository for archiving raw sequence data, which provides data storage and sharing services for worldwide scientific communities. Considering explosive data growth with diverse data types, here we present the GSA family by expanding into a set of resources for raw data archive with different purposes, namely, GSA (https://ngdc.cncb.ac.cn/gsa/), GSA for Human (GSA-Human, https://ngdc.cncb.ac.cn/gsa-human/), and Open Archive for Miscellaneous Data (OMIX, https://ngdc.cncb.ac.cn/omix/). Compared with the 2017 version, GSA has been significantly updated in data model, online functionalities, and web interfaces. GSA-Human, as a new partner of GSA, is a data repository specialized in human genetics-related data with controlled access and security. OMIX, as a critical complement to the two resources mentioned above, is an open archive for miscellaneous data. Together, all these resources form a family of resources dedicated to archiving explosive data with diverse types, accepting data submissions from all over the world, and providing free open access to all publicly available data in support of worldwide research activities.
Laparoscopic two-stage operation for obstructive left-sided colorectal cancer: A case report
Authors: Nguyen Hai V. , Nguyen Dung T.T. , Nguyen Anh T. , Phan Nam T. 
Published: August 2021

ABSTRACT

Introduction and importance:
The optimal treatment for obstructive left-sided colorectal cancer (OLCC) remains controversial. While open multi-stage operation is accepted widely, proportion of using laparoscopic surgery remains low with the conversion rate to open surgery up to 25%. Studies about performing laparoscopic surgery in all stages of treatment patients with resectable OLCC are scarce on literature, probably owing to difficulties of performing the operation in acute colonic obstruction. Here we report a patient with OLCC who was treated by laparoscopic two-stage operation in the same admission.

Case presentation:
A 87-year-old male admitted with symptoms and signs of low intestinal obstruction for 10 days. He had no severe comorbidities, except right hip joint replacement 10 years before. Clinical and CT findings confirmed obstructive middle rectal cancer which was at stage cT3N2Mx. Because endoscopic stent placement and neoadjuvant chemoradiotherapy were not available, multidisciplinary conference decided to perform laparoscopic two-stage operation. Laparoscopic loop colostomy was performed first with operative time of 65 minutes. In the first postoperative period, the patient was stabilized, fully evaluated and prepared for laparoscopic curative resection at postoperative day 12. The second intraoperative course was favourable with operative time of 215 minutes. The patient's recovery was uneventful. Total hospital stay was 20 days.

Clinical discussion:
Laparoscopic two-stage operation for OLCC is challenging but feasible. This approach requires both experienced laparoscopic colorectal surgeons and carefully selected patients. With the short interval between stages, adhesion and tumor spread may not be important consideration.

Conclusion:
Laparoscopic two-stage operation is feasible, effective, and should be considered in treatment of selected patients with OLCC.

Highlights
Pornography Addiction: An Exploration of the Association Between Use, Perceived Addiction, Erectile Dysfunction, Premature (Early) Ejaculation, and Sexual Satisfaction in Males Aged 18-44 Years
Authors: Whelan Georgina , Brown Jac 
Published: August 2021

ABSTRACTINTRODUCTIONThe way men consume pornography changed over the last decade, with increased numbers of men presenting with self-perceived Internet pornography (IP) addiction and related sexual dysfunction. A lack of consensus and formal recognition in the DSM-5 lead to a variety of definitions of IP addiction. Currently, the majority of evidence linking IP addiction and sexual dysfunction was derived from consumers, case studies, and qualitative research. Where empirical measures were used, researchers found mixed outcomes in sexual response. Inconclusive data appeared to relate to the conflation of IP use and self-perceived IP addiction, and normal variations in sexual response with clinical diagnosis of sexual dysfunction. Thus, further empirical clarification is required to assess the impact of both IP use and self-perceived IP addiction, on men’s sexual function.AimsThis study has 3 aims: First, to assess if there is an association between IP use alone and erectile dysfunction (ED), premature (early) ejaculation (EE) and sexual satisfaction (SS); Second, to assess whether there is an association between self-perceived IP addiction and ED, EE and SS. Third, to assess whether IP use or self-perceived IP addiction uniquely predicts ED, EE, SS in men.MethodCorrelation and regression analysis was conducted on a cross-sectional sample of 942 heterosexual men aged 18-44 years who participated in an online survey sourced from Reddit IP subgroups.Main Outcome MeasuresCyber-Pornography Use Inventory; International Index Erectile Dysfunction; The Checklist for Early Ejaculation Symptoms; New Sexual Satisfaction Scale; Depression Anxiety Stress Scale-21.RESULTSThere was no evidence for an association between IP use with ED, EE, or SS. However, there were small to moderate positive correlations between self-perceived IP addiction and ED, EE and sexual dissatisfaction. Further, self-perceived IP addiction uniquely predicted increased ED, EE and individual sexual dissatisfaction. Contrary to expectations, self-perceived IP addiction did not predict sexual dissatisfaction with one’s sexual partner.CONCLUSIONThese results suggest that IP use alone does not predict sexual dysfunction. Rather, self-perception of increased IP addiction was related to negative sexual outcomes. Thus, we concluded that subjective interpretation of ones IP use was a contributor to IP related sexual problems in our sample of males who share IP on social media sites. We recommend that clinicians consider self-perceived IP addiction as a possible contributing factor to sexual dysfunction.
Colonial Chaos in the Southern Red Sea
Authors: Smith Nicholas W. Stephenson 
Published: August 2021

Today, the countries bordering the Red Sea are riven with instability. Why are the region's contemporary problems so persistent and interlinked? Through the stories of three compelling characters, Colonial Chaos sheds light on the unfurling of anarchy and violence during the colonial era. A noble Somali sultan, a cunning Yemeni militia leader, and a Machiavellian French merchant ran amok in the southern Red Sea in the nineteenth and twentieth century. In response to colonial hostility and gunboat diplomacy, they attacked shipwrecks, launched piratical attacks, and traded arms, slaves, and drugs. Their actions contributed to the transformation of the region's international relations, redrew the political map, upended its diplomatic culture, and remodelled its traditions of maritime law, sowing the seeds of future unrest. Colonisation created chaos in the southern Red Sea. Colonial Chaos offers an interdisciplinary approach to understanding the relationship between the region's colonial past and its contemporary instability.
The Rockefeller Team Science Leadership training program: Curriculum, standardized assessment of competencies, and impact of returning assessments
Authors: Vaughan Roger , Romanick Michelle , Brassil Donna , Kost Rhonda , Neville-Williams Maija , Gottesman Riva , Devine Rita , Manukonda Prasanth , Ronning Andrea , O’Sullivan Barbara , Capili Bernadette , Macarthur Robert , Tobin Jonathan N. , Johnson Tesheia , Shapiro Eugene D. , Meagher Emma , Krueger James , Schlesinger Sarah , Coller Barry S. 
Published: August 2021

Abstract
The ability to effectively lead an interdisciplinary translational team is a crucial component of team science success. Most KL2 Clinical Scholars have been members of scientific teams, but few have been team science leaders. There is a dearth of literature and outcome measures of effective Team Science Leadership in clinical and translational research. We focused our curriculum to emphasize Team Science Leadership, developed a list of Team Science Leadership competencies for translational investigators using a modified Delphi method, and incorporated the competencies into a quantitative evaluation survey. The survey is completed on entry and annually thereafter by the Scholar; the Scholar’s primary mentor and senior staff who educate and interact with the Scholar rate the Scholar at the end of each year. The program leaders and mentor review the results with each Scholar. The survey scales had high internal consistency and good factor structure. Overall ratings by mentors and senior staff were generally high, but ratings by Scholars tended to be lower, offering opportunities for discussion and career planning. Scholars rated the process favorably. A Team Science Leadership curriculum and periodic survey of attained competencies can inform individual career development and guide team science curriculum development.
Primary decomposition in the smooth concordance group of topologically slice knots
Authors: Cha Jae Choon 
Published: August 2021

AbstractWe address primary decomposition conjectures for knot concordance groups, which predict direct sum decompositions into primary parts. We show that the smooth concordance group of topologically slice knots has a large subgroup for which the conjectures are true and there are infinitely many primary parts, each of which has infinite rank. This supports the conjectures for topologically slice knots. We also prove analogues for the associated graded groups of the bipolar filtration of topologically slice knots. Among ingredients of the proof, we use amenable$L^2$-signatures, Ozsváth-Szabód-invariants and Némethi’s result on Heegaard Floer homology of Seifert 3-manifolds. In an appendix, we present a general formulation of the notion of primary decomposition.
The associations of butyrate-producing bacteria of the gut microbiome with diet quality and muscle health
Authors: Davis Jessica A , Collier Fiona , Mohebbi Mohammadreza , Pasco Julie A , Shivappa Nitin , Hébert James R , Jacka Felice N , Loughman Amy 
Published: August 2021

ABSTRACTThis study aimed to investigate the relationships between diet quality, the relative abundance of butyrate-producing bacteria of the gut microbiome and muscle mass, strength and function. In this cross-sectional study,n = 490 men (64.4 ± 13.5 years) from the Geelong Osteoporosis Study provided food frequency questionnaire data, from which the Australian Recommended Food Score (ARFS) and Dietary Inflammatory Index (DII) score were calculated. Muscle mass (skeletal muscle index from DXA-derived lean mass), muscle strength (handgrip strength) and muscle function (Timed Up-and-Go test) were measured. Participants provided stool samples for 16S rRNA gene sequencing. There was no evidence of associations between alpha or beta diversity and muscle health measures. A healthier ARFS score was positively associated with the relative abundance of butyrate-producing bacteria (β0.09, 95%CI 0.03, 0.15) and a higher (pro-inflammatory) DII score was associated with lower relative abundance of butyrate-producing bacteria (β−0.60, 95%CI −1.06, −0.15). The relative abundance of butyrate-producing bacteria was positively associated with healthier muscle mass, strength and function; however, these relationships were attenuated in multivariable models. These findings support the role of diet quality in achieving a healthier gut microbiome, however, further evidence is required for a gut-muscle axis in humans.