bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT OF A MULTI-MODE ACCUMULATIVE MARKOV SYSTEM
Authors: Yuri Filonov  , Zoya Nagolkina  
Published: October 2021

Systems are considered that earn a resource, monetary in the economic interpretation, and use it for functioning and accumulation. The conditions for the growth of savings are sought, which simultaneously ensure the non-positivity of the governing Markov chain. The widespread inhomogeneity of the phase space is essential. In the phase space (of a general type) of such a system, a nonnegative function , a function with values 1,2,…, , an irreducible homogeneous Markov chain , n = 0,1,… are given. The values indicate the resource level of the system at time n, the values indicate the mode, which is determined by the number of service locations, devices, service lines, the number of offices, workers, etc., the type of functioning as repair, prevention, downtime work. Let be the average increments of ver the 1-st period for an arbitrary set набора , states, is the probability of transition from the state into mode is the corresponding stochastic matrix, and – is the stationary probability distribution for it. Let be the value of increased by the value of an arbitrary function ψ (x)> 0, monotone and integrable on the interval [0, ∞). In a fairly general case, based on other of the authors' works, it is argued that the condition for large X (w_i) is sufficient for the system to be acceptable in the sense that there is a convergence to 1 of the relative fraction of that time until the moment n, when the level X> C, (as n → ∞ with probability 1, for an arbitrarily large level C). That is, in a time relation that tends to 1, the functioning will take place in an ever better financial condition. Models are also considered that use the asymptotics and the model of deterioration of the system quality in a random way, but gradually, until unfavorable modes and the subsequent transition to the initial favorable mode, after the recovery mode, and further in a similar way. In this case, under the conditions of acceptability, it is not the stationary probabilities that are used, but the probabilities of system deterioration. It examines economic analogies with insurance and profitability.
THE OPTIMIZING APPROACH TO DETERMINATION THE PARAMETERS OF AN INACCESSIBLE POINT
Authors: Aleksandr Brailov  , Vitaliy Panchenko  
Published: October 2021

In the present research the optimizing approach to the determination of the parameters of an inaccessible point of an object is developed. The common issues are revealed and essential steps of their resolution are identified.The essence of the problem is that the unavoidable contradiction between a need of obtaining the exact value of the determined parameter and an error involved in any measurement. The purpose of the present work is to develop in a complex three-dimensional geometrical and analytical models of the determination of the minimum domain (area, vicinity) of values of the parameters of an inaccessible point of an object.It is achieved in two steps: 1. Development of a three-dimensional geometrical model with crossed directional rays for contactless determination of the coordinates of an inaccessible point of an object under a given arrangement of the geodetic equipment. 2. Development of an optimizing analytical model for the determination of domain (area, vicinity) of values of parameters of an inaccessible point of an object according to the developed three-dimensional geometrical model with crossed directional rays. In the proposed optimizing approach, the three-dimensional geometrical model with crossed directional rays for the determination of coordinates of the inaccessible point of an object is developed. It is discussed that points С and C', coordinated of which to be determined, locates in domain [CDM, CEM], [C'D'M, C'E'M] of the minimum distance ρmin between crossed directional rays. The optimizing problem of the determination of coordinates of an inaccessible point of an object in space is reduced to a problem of the determination of the minimum distance between two crossed directional rays. It is shown that the problem has a unique solution if the directional rays are not parallel. It is discussed that mathematical finding of an extremum of function of the distance between two directional rays, and the discussed minimum, has real geometrical interpretation.It’s known from the theory of function of multiple variables that function ρ = f (tC'D', tC'E') reaches its extremum ρmin when its partial derivatives by each variable are equal to zero. Therefore, the system of the differential equations solved. The required point C' (xC', yC', zC') can be located, for example, in the middle of the minimum segment [C'D'M, C'E'M]. The proposed approach is verified using real experimental data.
Analisis Pengaruh Stres Kerja Dan Disiplin Kerja Terhadap Kepuasan Kerja (Studi Pada Pegawai PT Angkasa Pura II (Persero) Kantor Cabang Bandara Husein Sastranegara Bandung)
Authors: Simarmata Ricardo Manarintar 
Published: October 2021

Penelitian ini bertujuan untuk melihat Analisis Pengaruh Stres Kerja Dan Disiplin Kerja Terhadap Kepuasan Kerja Pegawai (Studi pada pegawai PT Angkasa Pura II (Persero) Kantor Cabang Bandara Husein Sastranegara Bandung. Populasi dalam penelitian ini adalah pegawai PT Angkasa Pura II (Persero) Kantor Cabang Bandara Husein Sastranegara Bandung, yaitu 192 orang. Teknik pengambilan sampel yang digunakan dalam penelitian ini menggunakan teknik probability sampling. Penelitian ini akan menguji analisis pengaruh stress kerja dan disiplin kerja terhadap kepuasan kerja (studi pada pegawai PT Angkasa Pura II (Persero) Kantor Cabang Bandara Husein Sastranegara Bandung). Dalam penelitian kali ini, teknik analisis yang akan digunakan adalah multiple regression. Peneliti menemukan bahwa sebagian besar item sudah cukup valid dalam mengukur variabel yang ingin diukur. Namun, peneliti menemukan pada variabel disiplin kerja, item nomor 13 dan 21 dinyatakan tidak valid dan pada variabel kepuasan kerja item nomor 32 dan 33 dinyatakan tidak valid. Ketiga variabel yang diteliti (stres kerja, disiplin kerja dan kepuasan kerja) dapat dianggap sudah reliabel. Karena memiliki nilai reliabilitas Alpa Cronbach lebih dari 0.6. Dari hasil penelitian, para responden memiliki stres kerja yang berada di taraf tinggi, disiplin kerja yang berada di taraf rendah, dan kepuasan kerja yang berada di taraf rendah. Terdapat pengaruh yang signifikan secara simultan stres kerja dan disiplin kerja terhadap kepuasan kerja para responden pegawai PT Angkasa Pura II (Persero) Kantor Cabang Bandara Husein Sastranegara Bandung.
hiperplasia linfoide cutanea de células b
Authors: Redondo Bermúdez César , Camacho Chaljub Francisco , Redondo de Oro Katherine , Niño Hernández Lucía , Gutiérrez San Martín Joan , Payares Salgado Manuel 
Published: October 2021

Las hiperplasias cutáneas linfoides, antiguamente llamadas seudolinfomas cutáneos, son proliferaciones benignas de linfocitos, que simulan linfomas tanto clínica como histológicamente y de acuerdo a su componente celular más predominante puedenser clasificados como de células B o T. La de células B se considera una entidad clínicopatológica especifica, mientras que las de células T son un grupo heterogéneo de enfermedades, más que una enfermedad en sí. Dado que no son tan frecuentes no se tienen datos precisos de su epidemiología. Se presenta caso clínico de paciente de sexo femenino de 45 años con un nódulo eritematoso y violáceo en la región frontal de más de un año de evolución con reporte histopatológico confirmado por estudios de inmunohistoquímica de hiperplasia cutánea linfoide de células B. Rev.cienc.biomed.2011; 2(1): 98-105
Tétanos generalizado : revisión a propósito de un caso.
Authors: Abuabara Franco Emilio , Bohórquez Rivero José , Ortega Gaibao María , Vargas Acosta Brian , Puentes López Sindy Paola , Peña Vera Wiston , Restom Arrieta José Gabriel , Rico Fontalvo Jorge 
Published: October 2021

Introducción: el tétanos es una enfermedad causada por una toxina producida por la bacteria Clostridium tetani. Se caracteriza clínicamente por rigidez generalizada y espasmos musculares capaces de causar paro respiratorio y muerte. La población de alto riesgo incluye a los adultos mayores, los diabéticos, los usuarios de drogas inyectables y las personas no vacunadas. El diagnóstico de tétanos es cada vez más raro, con la implementación de programas de vacunación obligatoria se ha logrado disminuir la incidencia de esta enfermedad a nivel mundial; no obstante, sigue teniendo una morbimortalidad significativa. Objetivo: describir el caso de un paciente masculino con tétanos generalizado con el fin de reforzar la relevancia de la vacunación, profilaxis, su diagnóstico precoz y tratamiento oportuno. Caso clínico: paciente masculino de 18 años de edad que ingresa al servicio de urgencias remitido centro de atención primaria 10 días después de hacerse herida en miembro inferior derecho, que evolucionó hasta presentar fiebre, trismo, hipertonía y contracciones musculares generalizadas. Su esquema de inmunizaciones era desconocido y carecía de profilaxis antitetánica; por lo tanto, con base a los antecedentes y el cuadro clínico se hizo diagnóstico de tétanos generalizado accidental, se instauró tratamiento y se trasladó a la Unidad de Cuidados Intensivos. Las manifestaciones neurológicas fueron graves; sin embargo, evolucionó satisfactoriamente hasta la resolución completa del cuadro y fue dado de alta posteriormente. Conclusión: a pesar de que el tétanos es una patología que los médicos no ven usualmente en su práctica clínica, es una infección grave que todavía representa un importante desafío diagnóstico y terapéutico. La enfermedad se puede prevenir completamente mediante la vacunación y el cuidado adecuado de las heridas.
Methodological grounds of the patent landscape in the system of intellectual national security
Authors: Butnik-Siverskyi Oleksandr , Androshchuk Hennadii 
Published: October 2021

Keywords: intellectual property, national intellectual security, research methodology,patent landscape, comparative economic statistics
The articleexamines intellectual national security in security science as a new direction of development,which requires the development of theoretical and methodological grounds inobtaining results that are fixed in the course of grounding of real external and internalthreats. It is grounded the need for deep study of the development of an effectivemethodology of intellectual national security, which includes methods of the patentlandscape, that determined the purpose of the study, which was the methodology ofthe patent landscape on the economic nature and patterns of development of intellectualnational security in the direction of counteracting internal and external threats.It is noted that the patent landscape is not a tool that has features of completeness,but is considered as a research methodology that includes methods of search andanalysis, evaluation of the results and their effectiveness of impact. It is consideredthe methodology of the research of patent landscape for the purposes of intellectualnational security, which aims to generalize methodical approaches for various tasksof counteracting internal and external threats in the system of intellectual nationalsecurity and includes technological analysis, competitive analysis, territorial analysisand analysis of patent portfolio (patented intellectual assets) of specific company or companies and requires concrete methodical support and standardization of reporting,and in some cases the establishment of standards or substantive restrictions. Themethodology is considered as a large-scale variant of patent search and from theangle of the real state and prospects of transformation processes in the direction of researchingthreats to national security using known global databases of patent statisticsand comparative economic statistics to identify benefits or waste of financial andmaterial resources.
Novel Prognostic Predictor for Primary Pulmonary Hypertension: Focus on Blood Urea Nitrogen
Authors: Hu Bo , Xu Guangtao , Jin Xin , Chen Deqing , Qian Xiaolan , Li Wanlu , Xu Long , Zhu Jia , Tang Jie , Jin Xiuhui , Hou Jian 
Published: October 2021

Background: Primary pulmonary hypertension (PPH) is a life-threatening disease associated with increased mortality. The urea cycle pathway plays a major role in PPH severity and treatment response. Little is known about the association of the blood urea nitrogen (BUN) and PPH prognosis.Methods: Clinical data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Adult patients (≥18 years) patients with primary pulmonary hypertension (PPH) in the database were enrolled. Spearman correlation was used to analyze the association of BUN with length of hospital and intensive care unit (ICU) stays. The chi-square test was used to analyze the association of BUN with mortality rate. Survival curves were estimated using the Kaplan-Meier method and compared by the log-rank test. Multivariable logistic regression was used to identify the BUN as an independent prognostic factor of mortality. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used to analyze the sensitivity and specificity for mortality.Results: In total, 263 patients who met the selection criteria were enrolled. BUN was significantly positively associated with length of hospital stay and ICU stay (hospital stay: ρ = 0.282, ICU stay: ρ = 0.276; all P &lt; 0.001). Higher hospital, 90-day and 4-year mortality rates were observed in the higher BUN quartile of PPH patients (hospital: P = 0.002; 90-day: P = 0.025; 4-year: P &lt; 0.001). The Kaplan-Meier survival curves showed that patients in higher BUN quartile tended to have lower 4-year survival (Q1:7.65%, Q2: 10.71%; Q3: 14.80%, Q4: 16.84%; P &lt; 0.0001). Logistic regression analyses found a significant association of BUN and mortality (hospital: OR = 1.05, 95% CI = 1.02–1.08, P = 0.001; 90-day: OR = 1.02, 95% CI = 1.00–1.05, P = 0.027; 4-year: OR = 1.05, 95% CI = 1.02–1.08, P = 0.001). Results of ROC and AUC showed that the diagnostic performance of BUN for mortality was moderately good.Conclusion: BUN was positively correlated with the length of hospital stay and ICU stay of PPH patients. Higher BUN was associated with higher hospital, 90-day and 4-year mortality and lower 4-year survival of PPH patients. These findings indicate that BUN can be a novel potential prognostic predictor for PPH.
Peri-Implant Health and the Knowing-Doing Gap—A Digital Survey on Procedures and Therapies
Authors: Hussain Badra , Haugen Håvard Jostein , Aass Anne Merete , Sanz Mariano , Antonoglou Georgios N. , Bouchard Philippe , Bozic Darko , Eickholz Peter , Jepsen Karin , Jepsen Sören , Karaca Ebru Ozkan , Kuru Bahar Eren , Nemcovsky Carlos E. , Papapanou Panos N. , Pilloni Andrea , Renvert Stefan , Roccuzzo Mario , Sanz-Esporrin Javier , Spahr Axel , Stavropoulos Andreas , Verket Anders , Vražić Domagoj , Lyngstadaas Ståle Petter 
Published: October 2021

Objectives: Peri-implant tissue maintenance and treatment is becoming a serious challenge in implantology. With increasing numbers of implants being placed, more cases of peri-implant mucositis and peri-implantitis is seen. A digital survey on peri-implant disease management was issued to experts in periodontology and implantology to identify the tools and procedures most commonly used today to treat peri-implant diseases and successfully manage peri-implant health. The primary aim was to assess whether there is consensus in the choice of treatment to manage peri-implant diseases and to prevent their recurrence once treated. The secondary aim was to obtain insight into future protocols and /or devices, and the research and development needed.Materials and Methods: Participants in this digital survey were professionals specialising in periodontology, oral surgery, and implant dentistry. The questionnaire included both a series of closed- and open-ended questions. A total of 16 countries participated. The survey was sent by e-mail to 70 individuals, 66 received the survey and 37 of receivers responded, two of the participants were excluded due to insufficient filling of the survey. In the end 35 respondents completed the survey.Results: Respondents agree that the efficacy of mechanical and chemical decontamination of implant surfaces needs to be improved and better documented. It is a common opinion that the current remedies, mostly adapted from periodontal practises, do not provide effective and reliable clinical outcomes when treating peri-implant ailments. There is a general agreement amongst experts that regularly scheduled (3–6-month intervals) maintenance treatments are essential for maintaining peri-implant health in patients experiencing implant complications. Respondents are also concerned about unnecessary use of systemic antibiotics for managing peri-implant health.Conclusion: Regardless of agreements in parts, there was no observed consensus on the most effective treatment options for treating peri-implantitis. The experts all agree it is an urgent need for well-designed, long-term follow-up randomised and controlled clinical trials comparing interventions to provide an evidence-based strategy for peri-implant health management.
Vedolizumab for the Management of Refractory Behçet’s Disease: From a Case Report to New Pieces of Mosaic in a Complex Disease
Authors: Arbrile Marta , Radin Massimo , Rossi Daniela , Menegatti Elisa , Baldovino Simone , Sciascia Savino , Roccatello Dario 
Published: October 2021

ObjectivesWhen treating Behçet’s disease (BD), anti-tumor necrosis factor (TNF)-α agents have become a second-line therapy when conventional immunosuppressive drugs have failed. However, in the case of failure of treatment with anti-TNFα drugs, further options are limited. Based on previous reports of the efficacy of vedolizumab (VDZ) in inflammatory bowel diseases, we decided to administer VDZ to treat a patient with intestinal BD.MethodsWe present the case of a 49-year-old female patient with BD. Her clinical manifestations included erythema nodosum, oro-genital ulcers, positive Pathergy test, positive HLA-B51, and biopsy-proven intestinal BD. The patient was unsuccessfully treated with conventional immunosuppressive and several biological agents.ResultsTreatment with VDZ was started intravenously at a dose of 300 mg at 0, 2, and 6 weeks and then every 4 weeks.After the second dose of VDZ, the patient reported a marked improvement of intestinal BD and a concomitant amelioration of arthralgia, erythema nodosum lesions and aphthosis. Clinical remission was achieved at 6 months after starting VDZ.ConclusionVDZ might represent a valid option to treat patients with BD who are non-responsive to standard treatments or anti-TNFα agents, particularly, those cases with intestinal involvement.
Layered Metamaterial Beam Structures With Local Resonators for Vibration Attenuation: Model and Experiment
Authors: Anigbogu Winner , Nguyen Hieu , Bardaweel Hamzeh 
Published: October 2021

Layered metamaterial beam structures are gaining attention in a variety of fields including vibration attenuation and energy harvesting. Exhaustive research on single-beam metamaterial vibration attenuation structures using local resonators exists in literature. Moreover, there are recent attempts at modelling double-layered beams with different kinds of constraints. The double-layered beam models in literature are limited to simple beams and not extended to metamaterials with local resonators. This article is focused on developing a design criterion and a modelling platform for layered metamaterial structures with multiple beams and local resonators for vibration isolation. The model is developed using Euler-Bernoulli beam equations, superposition of mode shapes and Galerkin methods. A prototype layered metamaterial structure is fabricated and characterized experimentally. The prototype consists of horizontal beams, local resonators forming unit cells, and vertical beams linkages. Each local resonator consists of cantilevers with tip masses. Results show good agreement between model and experiment. Two major bandgaps are observed at 190–410 Hz and 550–710 Hz. Results reveal that the low frequency bandgap can be further reduced through the design of the local resonators. Results also show that alternating the length of the local resonators causes a shift in the first frequency bandgap. An increase in the number of local resonators opens up extra frequency bandgaps at lower frequencies with the drawback of reducing the depth in vibration transmissibility. Moreover, the higher frequency bandgaps are mostly affected by the horizontal beams. An increase in the length of the horizontal beams, while the number and design of the local resonators are fixed, broadens the second frequency bandgap and shifts it to lower values.
Predictors of Mortality in Critically Ill Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Authors: Zhang Yuqi , Guo Jinyan , Zhang Panpan , Zhang Lei , Duan Xiaoguang , Shi Xiaofei , Guo Nailiang , Liu Shengyun 
Published: October 2021

Background: Patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) may require intensive care unit (ICU) admission due to different reasons, and the in-ICU mortality is high among AAV patients. The aim of this study was to explore the clinical features and risk factors of mortality of patients with AAV in the ICU.Methods: A retrospective study was conducted based on 83 AAV patients admitted to the ICU in a tertiary medical institution in China. Data on clinical characteristics, laboratory tests, treatment in ICU and outcomes were collected. The data were analyzed using univariate and multivariate logistic regression analysis to explore the variables that were independently related to mortality. Kaplan–Meier method was used to assess the long-term survival.Results: Among the 83 patients, 41 (49.4%) were female. The mean age of patients was 66 ± 13 years. Forty-four patients deceased, with the in-ICU mortality of 53%. The most common cause for ICU admission was active vasculitis (40/83, 48.2%). The main cause of death was infection (27/44, 61.4%) followed by active vasculitis (15/44, 34.1%). A multivariate analysis revealed that the Acute Physiology and Chronic Health Evaluation II (APACHE II) at ICU admission (OR = 1.333, 95% CI: 1.031–1.722) and respiratory failure (OR = 620.452, 95% CI: 11.495–33490.306) were independent risk factors of in-ICU death. However, hemoglobin (OR = 0.919, 95% CI: 0.849–0.995) was an independent protective factor. The nomogram established in this study was practical in predicting the risk of in-ICU mortality for AAV patients. Moreover, for 39 patients survived to the ICU stay, the cumulative survival rates at 0.5, 1, and 5 years were 58.3%, 54.2%, and 33.9%, respectively, and the median survival time was 14 months.Conclusion: In our study, active vasculitis was the most frequent reason for ICU admission, and the main cause of death was infection. APACHE II and respiratory failure were independent risk factors while hemoglobin was an independent protective factor of in-ICU mortality for AAV patients admitted to the ICU. The risk prediction model developed in this study may be a useful tool for clinicians in early recognition of high-risk patients and applying appropriate management.