bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ophthalmological changes in patients with COVID-19 associated pneumonia
Authors:   Tyumen State Medical University, Tyumen, Kalyuzhnaya E. N. ,   Tyumen Industrial University, Tyumen, Ponomareva M. N. ,   Tyumen State Medical University, Tyumen, Petrov I. M. ,   Tyumen State Medical University, Tyumen, Naymushina A. G. ,   Tyumen Industrial University, Tyumen, Gapon L. I. ,   Tyumen Scientific Center for Cardiology – Branch of the Tomsk Scientific Research Center of the RAS, Tyumen, Petelina T. I. ,   Tyumen Scientific Center for Cardiology – Branch of the Tomsk Scientific Research Center of the RAS, Tyumen, Yaroslavskaya E. I. ,   Tyumen Scientific Center for Cardiology – Branch of the Tomsk Scientific Research Center of the RAS, Tyumen
Published: February 2021

Definition of COVID-19 (CoronaVirusDesease 2019) is a severe acute respiratory infection caused by the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2). On March 11, 2020, WHO announced the beginning of the COVID-19 pandemic. According to Rospotrebnadzor in Russia, the disease is asymptomatic in 23% of patients, 63% have manifestations of acute upper respiratory tract infection, and 14% pneumonia occurs. The average mortality rate in the world is about 3%. The first cases of the disease were reported in Wuhan (Hubei province, in the southeast of China) in December 2019.Despite the measures taken to prevent the spread of the new infection, in February the epidemic covered many countries, including Italy, South Korea, Iran, and in March it turned into a pandemic. Objective: to identify ophthalmological changes in patients who have had COVID-19 associated pneumonia. Materials and methods: 153 patients over 18 years of age with a confirmed diagnosis of COVID-19 associated pneumonia were examined 3 months after discharge from the hospital. Results and discussion: 7.84% – chronic blepharitis, 5.88% – chronic conjunctivitis, 60.0% – dry eye syndrome, 5.8% – degenerative conjunctival changes (5.88%) and 100% changes in conjunctival hemodynamics characteristic of hypercoagulation syndrome. Conclusions: in all cases of observation, a violation of hemodynamic changes in the conjunctiva was detected.
Obesity and body weight deficiency as predictors of gestational hypertension and cardiovascular disease
Authors:   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Popov A. D. , Zuevskaya T. V. ,   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Chernaya E. S. ,   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Sadrieva E. V. ,   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Pavlov P. I. ,   Regional Hospital of KhMAO-Ugra, Khanty-Mansiysk
Published: February 2021

Purpose of work. To reveal possible predictors of cardiovascular diseases on the basis of studying mechanisms of gestational adaptation, parameters of homeostasis in women with obesity and body weight deficiency. Material and methods. During pregnancy in 297 patients with changed body weight and 107 women of the comparison group carried out dynamic study of homeostasis parameters and adaptation mechanisms. The clinical state was assessed using morphological, electrophysiological, hormonal, biochemical and microbiological methods. Results. Analysis of anamnestic data revealed that parents of 87% of patients with obesity and weight deficit had arterial hypertension combined with atherosclerosis, obesity, diabetes mellitus, and depression. The upper distribution of subcutaneous tissue and gestational hypertension were found to be prevalent in women of the main clinical group: during the whole period, the average blood pressure was exceeded in obese women and in women with a deficit of body weight in the second trimester. General cholesterol level in the second trimester was increased due to atherogenic fractions in pregnant women of the first group up to 6.21 ± 0.13 mmol/l, in the second group – 5.95 ± 0.20 mmol/l, against the control group 4.96 ± 0.31 mmol/l. Transitor glucosuria (in case of excluded diabetes mellitus) occurred only in pregnant women with changed body weight in the 2nd trimester. Stress reactions prevailed in women with obesity and deficit of body weight on the eve of labor: 77% (1) and 88% (2), exceeding the parameters of the control group; there was also an increase in the level of norepinephrine and dioxyphenylalanine in daily excretion of urine by 4-6 times. Decrease in species landscape of intestinal and vaginal flora with increasing share of pathogenic microorganisms was registered in 91% of pregnant main groups and only in 33% of control group patients. Conclusion. In women with changed body weight, pregnancy is accompanied by excessive activation and disintegration of adaptation systems, the clinical equivalent of which is gestational hypertension, metabolic and microecology disorders. Gestational stress-test allows to estimate phylogenetic features of response systems of young women and probable ontogenetic risks of cardiovascular diseases.
Urinary nitrogen excretion at the early stage of severe acute pancreatitis
Authors:   Medical hospital «Neftyannik», Tyumen, Sivkov O. G. , Sivkov A. O. ,   Medical hospital «Neftyannik», Tyumen
Published: February 2021

Aim. To study urinary nitrogen excretion at the early stage of severe acute pancreatitis. Materials and methods. Prospective, single-center, cohort study. Inclusion criteria: diagnosis of acute pancreatitis and presence of at least one of the predictors of severe course. Among all patients (n = 72), a cohort of patients with severe acute pancreatitis (n = 32) was allocated. Three groups were formed in it: the first one – all patients, the second one – survivors (n = 24), the third one – deceased (n = 8). Urinary nitrogen excretion was determined using the Deacon formula. Measurements were performed on the first, third and fifth days of the disease. Statistical processing of the material was carried out by the SPSS software package. The null hypothesis was rejected at p < 0.05. Results. In the first week of the disease in all groups, the maximum urinary nitrogen excretion occurs on the 3rd day. When comparing the results of the second and third groups, it was found that the urinary nitrogen excretion on the first and fifth days did not have a statistically significant difference between the groups (respectively, p = 0.138, p = 0.572), and the results of the third day have (p = 0.014). A similar pattern remains when recalculating the nitrogen loss in the urine to the ideal weight; for the third day, the differences between the second and third groups were statistically significant (p = 0.007). ROC analysis of urinary nitrogen excretion of the third day calculated to the ideal body weight showed an area under the curve of 0.813 (p < 0.009). The value at the cut-off point is defined as 0.65 g/kg/day. The sensitivity of the model was 0.75%, specificity – 0.83%. Conclusion. If in a patient with acute pancreatitis, there is urinary nitrogen excretion on the third day from the onset of the disease, calculated to an ideal body weight of ≥ 0.65 g/kg/day, an unfavorable outcome of the disease is predicted.
Structure of comorbide disorders in ticose hyperkinesis in children
Authors:   Tyumen State Medical University, Tyumen, Levitina E. V. , Kolchanova M. U. ,   Regional Clinical Hospital No. 2, Tyumen, Rakhmanina O. A. ,   Tyumen State Medical University, Tyumen, Hramova E. B. ,   Tyumen State Medical University, Tyumen
Published: February 2021

Purpose. To study the structure of comorbid disorders in children with tycotic hyperkinesis of the city of Tyumen. Materials and methods. We examined 103 children aged 5 to 14 years. Patients were divided into 2 groups: group 1 – local tics (n = 43), group 2 – common tics (n = 60). All patients received anticitotic therapy. Using various scales and questionnaires, an assessment of tic hyperkinesis, the level of anxiety, a study of the rational, emotional and behavioral components of the relationship between parents and a child, an investigation of the emotional sphere, and neuropsychological testing were carried out. Results. Manifestations of ticks contribute to various stressful situations, school adaptation stress. The tics are intensified by emotional overstrain, mental overwork, eye strain. A risk factor for the formation of tic hyperkinesis is family education by the type of symbiosis and hypersocialization. Comorbid disorders in patients with ticose hyperkinesis in most cases are represented by ADHD, anxiety, the prevalence of a combination of stress with pathological compensation, and the presence of a headache. The neuropsychological plan revealed impaired attention, auditory-speech and visual memory, and writing. Conclusion. Identified comorbid disorders in children with tic hyperkinesis significantly reduce the quality of life of patients, disrupts their social adaptation and require timely correction.
Targeted Cancer Therapy and Its Ophthalmic Side Effects: A Review
Authors: Bindiganavile Shruthi Harish , Bhat Nita , Lee Andrew G. , Gombos Dan S. , Al-Zubidi Nagham 
Published: February 2021

ABSTRACT
Targeted cancer therapy agents are the latest development in cancer therapeutics. Although the spectrum of their use continues to expand, ocular side effects are frequently encountered with the use of cancer therapeutics. This review describes the ocular side effects of targeted cancer therapy agents.
How Political situation affected Major Stock’s Abnormal Return in Indonesia
Authors: Sevriana Lufthia , Febrian Erie 
Published: February 2021

This study presents data on abnormal stock return movements with simple calculations. The result of deep analysis using event study method from major stocks in each sector, prove that There is negative response by the market to the student demonstration during the end of September 2019 that create abnormal return condition until it gets back to be normal in the middle of October. The sectors studied include the banking sector, construction, infrastructure, consumer needs, media, industrial materials, machinery, mining, and health care. Stock returns in Indonesia with inefficient market conditions are vulnerable to issues. Capital markets tend to be easily influenced by political and macroeconomic conditions, but even though the condition of return is abnormal, investors still have the potential to get favourable results.
Keywords: Stock market, Market efficiency, Event study, Stock Price, Stock Returns
DETERMINATION OF CLINICAL INDICATORS OF INTERSTITIAL PRESSURE IN DEEP AND BORDERLINE BURNS DEPENDING ON THE TIME OF THERMAL INJURY
Authors: Kravtsov O. V. , Kurbanov T. A. , Kozin Yu. I. , Tsogoev A. A. , Gopko A.O. 
Published: February 2021

Summary. Objective. Improvement of the diagnosis of compartment syndrome depending on the time of thermal injury and the establishment of indications for draining operations.
Materials and methods. Interstitial pressure was studied in 66 victims who were admitted to the burn center in the first 24 hours after the injury. The patients were divided into groups depending on the relative extent of the lesion and the length of hospitalization.
The results of the study and their discussion. Upon admission of the patient to the department, a thorough sanitation of the burn surfaces was performed with antiseptic solutions (chlorhexidine, dekasan). In the burn area, the interstitial pressure was measured in all muscle groups deeper than the superficial fascia with a Kompartment druck Monitor System (MIPM Mammen dorfer Institut für Physik und Medizin Gmbh) apparatus for measuring interstitial pressure. Depending on the level of interstitial pressure, patients underwent conservative drug and infusion therapy aimed at reducing edema and hypoxia of damaged tissues. In the case of critical indicators of interstitial pressure, an urgent surgical intervention was performed for the purpose of decompression. When assessing the dependence of the pressure level in the tissues on the timing of burns, there is a clear dependence in all observation groups: late hospitalizations are accompanied by a large increase in pressure, the level of circular location of burns on the extremities is of great importance for high blood pressure.
Conclusion. It has been determined that objectification of the diagnosis of the compartment syndrome in order to prevent ischemic tissue damage plays an important role in deep and borderline burns. Clinical indicators of tissue pressure in deep and borderline burns have been established, depending on the time of thermal injury, which allows the diagnosis of compartment syndrome and the establishment of indications for drug, infusion therapy and urgent drainage operations.
The First Mapakers of the Ural Mines: Mikhail Silych Kutuzov
Authors: Цеменкова С.И. 
Published: February 2021

Статья посвящена реконструкции отдельных эпизодов жизни и деятельности известного уральского картографа Михаила Силыча Кутузова (1704–1741). Исследование его документального наследия, включающего визуальные (карты, чертежи, планы) и текстовые источники (отчеты),
а также сведения, извлеченные из делопроизводственной документации, позволяет проследить судьбу и особенности продвижения по службе представителя российского мелкопоместного дворянства в эпоху Петра I.
The article attempts to reconstruct certain episodes of life and work of a well-known Ural mapmaker Mikhail Silych Kutuzov (1704–1741). The analysis of his paper legacy, which includes official documents, as well as other visual (maps, drafts, plans) and textual (reports) sources, enables the author of the article to investigate Kutuzov’s life and work as a representative of Russian gentry of the epoch of Peter I.
ALMA Observations of the Inner Cavity in the Protoplanetary Disk around Sz 84
Authors: Hashimoto Jun , Muto Takayuki , Dong Ruobing , Hasegawa Yasuhiro , Marel Nienke van der , Tamura Motohide , Takami Michihiro , Momose Munetake 
Published: February 2021

Abstract
We present Atacama Large Millimeter/submillimeter Array observations of a protoplanetary disk around the T Tauri star Sz 84 and analyses of the structures of the inner cavity in the central region of the dust disk. Sz 84's spectral energy distribution (SED) has been known to exhibit negligible infrared excess at λ ≲ 10 μm due to the disk’s cavity structure. Analyses of the observed visibilities of dust continuum at 1.3 mm and the SED indicate that the size of the cavity in the disk of large (millimeter size) dust grains is 8 au in radius and that in the disk of small (submicron size) dust grains is 60 au in radius. Furthermore, from the SED analyses, we estimate that the upper limit mass of small dust grains at r < 60 au is less than ∼10−3 M
⊕, which is ≲0.01% of the total (small + large) dust mass at r < 60 au. These results suggest that large dust grains are dominant at r < 60 au, implying that dust grains efficiently grow with less efficient fragmentation in this region, potentially due to weak turbulence and/or stickier dust grains. The balance of grain growth and dust fragmentation is an important factor for determining the size of large dust grains in protoplanetary disks, and thus Sz 84 could serve as a good testbed for investigations of grain growth in such disks.
Damage to Relativistic Interstellar Spacecraft by ISM Impact Gas Accumulation
Authors: Drobny Jon , Cohen Alexander N. , Curreli Davide , Lubin Philip , Pelizzo Maria G. , Umansky Maxim 
Published: February 2021

Abstract
As part of the NASA Starlight collaboration, we look at the implications of impacts with the interstellar medium (ISM) on a directed energy-driven relativistic spacecraft. The spacecraft experiences a stream of MeV/nucleon impacts along the forward edge primarily from hydrogen and helium nuclei. The accumulation of implanted slowly diffusing gas atoms in solids drives damage through the meso-scale processes of bubble formation, blistering, and exfoliation. This results in macroscopic changes to material properties and, in the cases of blistering and exfoliation, material erosion via blister rupture and delamination. Relativistic hydrogen and helium at constant velocity will stop in the material at a similar depth, as predicted by Bethe–Bloch stopping and subsequent simulations of the implantation distribution, leading to a mixed hydrogen and helium system similar to that observed within fusion plasma-facing components. However, the difference in depth of near-surface gas atoms with respect to the direction of exposure means that previously developed empirical models of blistering cannot be used to predict bubble formation or blistering onset. In this work, we present a model of the local gas concentration threshold for material blistering from exposure to the ISM at relativistic speeds. Expected effects on the spacecraft and mitigation strategies are also discussed. The same considerations apply to the Breakthrough Starshot mission.
Mutual Neutralization in Li++H−/D− and Na++H−/D− Collisions: Implications of Experimental Results for Non-LTE Modeling of Stellar Spectra
Authors: Barklem Paul S. , Amarsi Anish M. , Grumer Jon , Eklund Gustav , Rosén Stefan , Ji MingChao , Cederquist Henrik , Zettergren Henning , Schmidt Henning T. 
Published: February 2021

Abstract
Advances in merged-beams instruments have allowed experimental studies of the mutual neutralization (MN) processes in collisions of both Li+ and Na+ ions with D− at energies below 1 eV. These experimental results place constraints on theoretical predictions of MN processes of Li+ and Na+ with H−, important for non-LTE modeling of Li and Na spectra in late-type stars. We compare experimental results with calculations for methods typically used to calculate MN processes, namely the full quantum (FQ) approach, and asymptotic model approaches based on the linear combination of atomic orbitals (LCAO) and semiempirical (SE) methods for deriving couplings. It is found that FQ calculations compare best overall with the experiments, followed by the LCAO, and the SE approaches. The experimental results together with the theoretical calculations, allow us to investigate the effects on modeled spectra and derived abundances and their uncertainties arising from uncertainties in the MN rates. Numerical experiments in a large grid of 1D model atmospheres, and a smaller set of 3D models, indicate that neglect of MN can lead to abundance errors of up to 0.1 dex (26%) for Li at low metallicity, and 0.2 dex (58%) for Na at high metallicity, while the uncertainties in the relevant MN rates as constrained by experiments correspond to uncertainties in abundances of much less than 0.01 dex (2%). This agreement for simple atoms gives confidence in the FQ, LCAO, and SE model approaches to be able to predict MN with the accuracy required for non-LTE modeling in stellar atmospheres.
Stromlo Stellar Tracks: Non-solar-scaled Abundances for Massive Stars
Authors: Grasha K. , Roy A. , Sutherland R. S. , Kewley L. J. 
Published: February 2021

Abstract
We present the Stromlo Stellar Tracks, a set of stellar evolutionary tracks, computed by modifying the Modules for Experiments in Stellar Astrophysics (MESA) 1D stellar evolution package, to fit the Galactic Concordance abundances for hot (T > 8000 K) massive (≥10 M
⊙) main-sequence (MS) stars. Until now, all stellar evolution tracks have been computed at solar, scaled-solar, or α-element-enhanced abundances, and none of these models correctly represent the Galactic Concordance abundances at different metallicities. This paper is the first implementation of Galactic Concordance abundances to the stellar evolution models. The Stromlo tracks cover massive stars (10 ≤ M/M
⊙ ≤ 300) with varying rotations (v/v
crit = 0.0, 0.2, 0.4) and a finely sampled grid of metallicities (−2.0 ≤ [Z/H] ≤ +0.5; Δ[Z/H] = 0.1) evolved from the pre-main sequence to the end of 12C burning. We find that the implementation of Galactic Concordance abundances is critical for the evolution of MS, massive hot stars in order to estimate accurate stellar outputs (L, T
eff, g), which, in turn, have a significant impact on determining the ionizing photon luminosity budgets. We additionally support prior findings of the importance that rotation plays on the evolution of massive stars and their ionizing budget. The evolutionary tracks for our Galactic Concordance abundance scaling provide a more empirically motivated approach than simple uniform abundance scaling with metallicity for the analysis of H ii regions and have considerable implications for determining nebular emission lines and metallicity. Therefore, it is important to refine existing stellar evolutionary models for comprehensive high-redshift extragalactic studies. The Stromlo tracks are available to the astronomical community.
Assessment of the Presence of PAHs and Hydrogenated PAHs in the Young Stellar Object Mon R2 and the Taurus Dense Cloud Toward Elias 16
Authors: Chiar J. E. , de Barros A. L. F. , Mattioda A. L. , Ricca A. 
Published: February 2021

Abstract
This study assesses the contribution of neutral polycyclic aromatic hydrocarbons (PAHs) and hydrogenated PAHs (H
n
-PAHs) in H2O-ices to the 3 μm and 5–8 μm regions of the infrared absorption spectrum of the Young Stellar Object, Mon R2 IRS 3, and the Taurus dense cloud in the direction of Elias 16. We compare the astronomical spectra to the previously published laboratory data of matrix-isolated PAHs and H
n
-PAHs in H2O-ices. For the molecules in this study, the band positions, FWHMs, and integrated band strengths have been measured. For the PAHs considered here, the ratio of the experimental A(C–H) stretch (in H2O ices) to the theoretical A(C–H) stretch (in the gas phase) is consistently about 0.10, meaning that the trove of theoretical data can be reliably scaled to compare to the astronomical spectra. We find that the fractional percentage contribution to the 5–8 μm region for Mon R2 IRS 3 ranges between 2.7 and 3.9 for neutral PAHs and 0.25–1.2 for H
n
-PAHs. The best match to the observed 3.25 μm profile in the Mon R2 IRS 3 spectrum is accomplished with the laboratory-measured coronene:H2O spectrum. Using this spectrum we estimate that neutral PAHs contribute up to 12.0% of the cosmic carbon budget for Mon R2 IRS 3 and <14.5% for Elias 16. Neutral hydrogenated PAHs contribute mainly to the 3.47 μm absorption and very little to the 5 to 8 μm region. For neutral H
n
-PAHs, we estimate that they contribute up to 0.6% of the cosmic carbon budget for Mon R2 IRS 3 and <1% for Elias 16.
Uncertainty Propagation in (Gaussian) Convolution
Authors: Klein Randolf 
Published: February 2021

Abstract
Convolution of spectra, maps, or even higher dimensional data is often part of data reduction or analysis. Often a Gaussian kernel is used. When the convolved data are measurements, they are associated with uncertainties. This research notice derives how uncertainties propagate through the convolution. While the math is straightforward algebra, the results are not readily available. Here, the uncertainty propagation applied to regularly gridded data is provided. The calculation is done for uncorrelated data and correlated data.