bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Activity and Exercise Patterns After Spontaneous Coronary Artery Dissection: Insights From a Large Multinational Registry
Authors: Chacin-Suarez Audry S. , Bonikowske Amanda R. , Medina-Inojosa Jose R. , Gulati Rajiv , Best Patricia J. , Hayes Sharonne N. , Tweet Marysia S. 
Published: June 2021

Objective: The objective of the study was to assess the physical activity (PA) and exercise patterns among participants in a large multinational spontaneous coronary artery dissection (SCAD) registry. Patients and Methods: Participants with SCAD enrolled from March 2011 to November 2019 completed surveys including details regarding PA and exercise habits prior to SCAD, and PA counseling received from their provider after SCAD. Demographics and clinical characteristics were collected by electronic record review. Exercise prescribed to patients after SCAD was categorized according to exercise components: type, intensity, frequency, time/session, and extreme environmental conditions.Results: We included 950 participants; mean ± age was 46.8 ± 9.5 years old at the time of first SCAD; most (96.3%) were women and (77.0%) attended ≥1 cardiac rehabilitation session. Hyperlipidemia (34.3%), hypertension (32.8%), and elevated body weight (overweight = 27.0%; obesity = 20.0%) were the most common comorbidities. Prior to SCAD, 48.5% performed aerobic exercise ≥3 times/week, and only 32.0% performed strength-building exercise regularly. PA counseling details after SCAD in 299/950 participants showed that most (93.3%) patients received some form of counseling including exercise prescription (EXP), non-specific recommendations, and discouraged from any exercise. Limits regarding exercise type and intensity were the most common advice among participants who received EXP.Conclusion: Insights from our study suggest that only 48% of the patients performed some aerobic exercise three or more times per week, and 32.0% performed strength-building exercises, which suggest that most of them may not be as active as assumed. Furthermore, 70% of the SCAD patients have ≥1 cardiovascular risk factors. We suggest guiding patients based on individual assessment, taking into consideration baseline PA habits, treatment, and risk factors. SCAD-tailored PA guidelines are needed for optimal EXP without compromising patient safety.
Circulating Neprilysin Level Predicts the Risk of Cardiovascular Events in Hemodialysis Patients
Authors: Hwang Hyeon Seok , Kim Jin Sug , Kim Yang Gyun , Lee Yu Ho , Lee Dong-Young , Ahn Shin Young , Moon Ju-Young , Lee Sang-Ho , Ko Gang-Jee , Jeong Kyung Hwan 
Published: June 2021

Background: Neprilysin inhibition has demonstrated impressive benefits in heart failure treatment, and is the current focus of interest in cardiovascular (CV) and kidney diseases. However, the role of circulating neprilysin as a biomarker for CV events is unclear in hemodialysis (HD) patients.Methods: A total of 439 HD patients from the K-cohort were enrolled from June 2016 to April 2019. The plasma neprilysin level and echocardiographic findings at baseline were examined. The patients were prospectively followed up to assess the primary endpoint (composite of CV events and cardiac events).Results: Plasma neprilysin level was positively correlated with left ventricular (LV) mass index, LV end-systolic volume, and LV end-diastolic volume. Multivariate linear regression analysis revealed that neprilysin level was negatively correlated with LV ejection fraction (β = −2.14; p = 0.013). The cumulative event rate of the composite of CV events was significantly greater in neprilysin tertile 3 (p = 0.049). Neprilysin tertile 3 was also associated with an increased cumulative event rate of cardiac events (p = 0.016). In Cox regression analysis, neprilysin tertile 3 was associated with a 2.61-fold risk for the composite of CV events [95% confidence interval (CI), 1.37–4.97] and a 2.72-fold risk for cardiac events (95% CI, 1.33–5.56) after adjustment for multiple variables.Conclusions: Higher circulating neprilysin levels independently predicted the composite of CV events and cardiac events in HD patients. The results of this study suggest the importance of future studies on the effect of neprilysin inhibition in reducing CV events.
Sleep Diagnostics for Home Monitoring of Sleep Apnea Patients
Authors: Huysmans Dorien , Borzée Pascal , Buyse Bertien , Testelmans Dries , Van Huffel Sabine , Varon Carolina 
Published: June 2021

Objectives:Sleep time information is essential for monitoring of obstructive sleep apnea (OSA), as the severity assessment depends on the number of breathing disturbances per hour of sleep. However, clinical procedures for sleep monitoring rely on numerous uncomfortable sensors, which could affect sleeping patterns. Therefore, an automated method to identify sleep intervals from unobtrusive data is required. However, most unobtrusive sensors suffer from data loss and sensitivity to movement artifacts. Thus, current sleep detection methods are inadequate, as these require long intervals of good quality. Moreover, sleep monitoring of OSA patients is often less reliable due to heart rate disturbances, movement and sleep fragmentation. The primary aim was to develop a sleep-wake classifier for sleep time estimation of suspected OSA patients, based on single short-term segments of their cardiac and respiratory signals. The secondary aim was to define metrics to detect OSA patients directly from their predicted sleep-wake pattern and prioritize them for clinical diagnosis.Methods:This study used a dataset of 183 suspected OSA patients, of which 36 test subjects. First, a convolutional neural network was designed for sleep-wake classification based on healthier patients (AHI &lt; 10). It employed single 30 s epochs of electrocardiograms and respiratory inductance plethysmograms. Sleep information and Total Sleep Time (TST) was derived for all patients using the short-term segments. Next, OSA patients were detected based on the average confidence of sleep predictions and the percentage of sleep-wake transitions in the predicted sleep architecture.Results:Sleep-wake classification on healthy, mild and moderate patients resulted in moderate κ scores of 0.51, 0.49, and 0.48, respectively. However, TST estimates decreased in accuracy with increasing AHI. Nevertheless, severe patients were detected with a sensitivity of 78% and specificity of 89%, and prioritized for clinical diagnosis. As such, their inaccurate TST estimate becomes irrelevant. Excluding detected OSA patients resulted in an overall estimated TST with a mean bias error of 21.9 (± 55.7) min and Pearson correlation of 0.74 to the reference.Conclusion:The presented framework offered a realistic tool for unobtrusive sleep monitoring of suspected OSA patients. Moreover, it enabled fast prioritization of severe patients for clinical diagnosis.
Zircon Genesis and Geochronology for the Zhangbaoshan Super-Large Rubidium Deposit in the Eastern Tianshan, NW China: Implication to Magmatic-Hydrothermal Evolution and Mineralization Processes
Authors: Zhi Jun , Lei Ruxiong , Chen Boyang , Muhtar M. N. , Feng Zhijie , Zhang Kai , Cai Yuanfeng , Wu Changzhi 
Published: June 2021

The Zhangbaoshan (ZBS) super-large Rubidium deposit, located in the Eastern Tianshan, is a typical granite-type Rb deposit. The ZBS deposit is mainly hosted in the highly evolved Baishitouquan (BST) pluton enriched in F and Rb, which exhibits five lithological zones from the bottom to the top: leucogranite (zone-a), amazonite-bearing granite (zone-b), amazonite granite (zone-c), topaz-bearing amazonite granite (zone-d) and topaz albite granite (zone-e), as well as minor small lodes of amazonite pegmatite. Two types of zircon were identified from the BST pluton. Type-I zircons mainly occur in the zone–a, are characterized by obvious oscillatory zoning, high Zr contents (47.4–67.3 wt% ZrO2) and Zr/Hf ratios (21.72–58.23), low trace element concentrations, and heavy rare earth elements (HREE)–enriched patterns with prominent positive Ce anomalies (Ce/Ce* = 1.21–385) and strong negative Eu anomalies (Eu/Eu* = 0.008–0.551), indicative of early magmatic zircon. Type–II zircons mainly occur in the upper zones (zone-c to zone-e), exhibit porous and dark Cathodoluminescence images, inhomogeneous internal structure, plenty of mineral inclusions, low Zr (38.7–51.0 wt% ZrO2) and Zr/Hf ratios (3.35–11.00), high Hf (34,094–85,754 ppm), Th (718–4,980 ppm), U (3,540–32,901 ppm), Ta (86.7–398 ppm), Y (1,630–28,890 ppm) and rare earth elements (REEs) (3,910–30,165 ppm), as well as slightly HREE–enriched patterns and significant M–type tetrad patterns with t3 values (quantification factor of tetrad effect) of 1.51–1.69. It is suggested that the type–II zircons are crystallized from a deuteric F–rich fluid coexisted with the highly evolved residual magma during the transition from the magmatic to the F–rich hydrothermal stage of the BST pluton. The F–rich fluid exsolution during the magmatic–hydrothermal transition is one of the most important factors controlling the modification of highly evolved granite and related Rb enrichment and mineralization. The type–I zircon samples from zone–a yield concordant ages of 250 ± 2.5 Ma and 250.5 ± 1.7 Ma, respectively, indicating that the BST pluton was emplaced in the Early Triassic. The type–II zircons from zone–c to zone–e yield lower intercept U–Pb ages between 238 and 257 Ma, which may represent the age of F–rich fluid–melt interaction during the transition from the magmatic to the hydrothermal stage. The mineralization of the ZBS super–large Rb deposit should have occurred shortly after emplacement of the BST pluton in the Early Triassic. Combined with available data, it is suggested that the Triassic is an important period for granitic magmatism and rare metal metallogeny in the Eastern Tianshan.
Associations Between Sleep Quality and Health Span: A Prospective Cohort Study Based on 328,850 UK Biobank Participants
Authors: Sambou Muhammed Lamin , Zhao Xiaoyu , Hong Tongtong , Fan Jingyi , Basnet Til Bahadur , Zhu Meng , Wang Cheng , Hang Dong , Jiang Yue , Dai Juncheng 
Published: June 2021

ObjectiveTo examine the associations between sleep quality and health span using a prospective cohort design based on the UK Biobank (UKB).Materials and MethodsThis longitudinal cohort study enrolled 328,850 participants aged between 37 and 73 years from UKB to examine the associations between sleep quality and risk of terminated health span. End of health span was defined by eight events strongly associated with longevity (cancer, death, congestive heart failure, myocardial infarction, chronic obstructive pulmonary disease, stroke, dementia, and diabetes), and a sleep score was generated according to five sleep behavioral factors (sleep duration, chronotype, sleeplessness, daytime sleepiness, and snoring) to characterize sleep quality. The hazard ratio (HR) and 95% confidence intervals (CIs) were calculated by multivariate-adjusted Cox proportional hazards model. Moreover, we calculated population attributable risk percentage (PAR%) to reflect the public health significance of healthy sleep quality.ResultsCompared with poor sleep quality, participants with healthy sleep quality had a 15% (HR: 0.85, 95% CI: 0.81–0.88) reduced risk of terminated health span, and those of less-healthy sleep quality had a 12% (HR: 0.88, 95% CI: 0.85–0.92) reduced risk. Linear trend results indicated that the risk of terminated health span decreased by 4% for every additional sleep score. Nearly 15% health span termination events in this cohort would have been prevented if a healthy sleep behavior pattern was adhered to (PAR%: 15.30, 95% CI: 12.58–17.93).ConclusionHealthy sleep quality was associated with a reduced risk of premature end of health span, suggesting healthy sleep behavior may extend health span. However, further studies are suggested for confirmation of causality and potential mechanism.
Age-Related Alterations in DTI Metrics in the Human Brain—Consequences for Age Correction
Authors: Behler Anna , Kassubek Jan , Müller Hans-Peter 
Published: June 2021

Background: Over the life span, the diffusion metrics in brain MRI show different, partly nonlinear changes. These age-dependent changes also seem to exhibit regional differences with respect to the brain anatomy. The age correction of a study cohort's diffusion metrics might thus require consideration of age-related factors.Methods: Diffusion tensor imaging data sets were acquired from 219 healthy participants at ages between 19 and 81 years. Fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivity (AD and RD, respectively) maps were analyzed by a tract of interest-based fiber tracking approach. To describe diffusion metrics as a function of the participant age, linear splines were used to perform curve fitting in 21 specific tract systems covering different functional areas and diffusion directions.Results: In the majority of tracts, an interpolation with a change of alteration rate during adult life described the diffusion properties more accurately than a linear model. Consequently, the diffusion properties remained relatively stable until a decrease (of FA) or increase (of MD, AD, and RD) started at a region-specific time point, whereas a uniform change of diffusion properties was observed only in a few tracts. Single tracts, e.g., located in the cerebellum, remained nearly unaltered throughout the ages between 19 and 81 years.Conclusions: Age corrections of diffusion properties should not be applied to all white matter regions and all age spans in the same way. Therefore, we propose three different approaches for age correction based on fiber tracking techniques, i.e., no correction for areas that do not experience age-related changes and two variants of an age correction depending on the age range of the cohort and the tracts considered.
Investigation of a Model-Based Working Memory Training With and Without Distractor Inhibition and Its Comparative Efficacy: A Randomized Controlled Trial on Healthy Old Adults
Authors: Zuber Priska , Geiter Emanuel , de Quervain Dominique J.-F. , Magon Stefano 
Published: June 2021

Background: Various working memory (WM) trainings have been tested, but differences in experimental designs, the lack of theoretical background, and the need of identifying task-related processes such as filtering efficiency limit conclusions about their comparative efficacy.Objectives: In this study, we compared the efficacy of a model-based WM training with (MB+) and without (MB) distractor inhibition on improving WM capacity to a dual n-back and active control condition.Methods: This randomized clinical trial included 123 healthy elderly adults (78 women, 45 men; aged 64.1 ± 8.3 years). All groups underwent 12 40-min training sessions over 3 weeks and four cognitive testing sessions. The first two sessions served as double baseline to account for practice effects. Primary outcome was WM capacity post-training measured by complex span tasks. Near and far transfer was assessed by simple span, n-back, visuospatial and verbal learning, processing speed, and reasoning tasks.Results: Due to preliminary termination (COVID-19), 93 subjects completed the post-training and 60 subjects the follow-up session. On a whole group level, practice effects occurred from prebaseline to baseline in WM capacity (b = 4.85, t(103) = 4.01, p &lt; 0.001, r = 0.37). Linear mixed-effects models revealed a difference in WM capacity post-training between MB+ and MB (b = −9.62, t(82) = −2.52, p = 0.014, r = 0.27) and a trend difference between MB+ and dual n-back (b = −7.59, t(82) = −1.87, p = 0.065, r = 0.20) and control training (b = −7.08, t(82) = −1.86, p = 0.067, r = 0.20). Univariate analyses showed an increase between pre- and post-training for WM capacity within MB+ (t(22) = −3.34, p &lt; 0.05) only. There was no difference between groups pre- and post-training regarding near and far transfer. Univariate analyses showed improved visuospatial learning within MB+ (t(21) = −3.8, p &lt; 0.05), improved processing speed (t(23) = 2.19, p&lt; 0.05) and n-back performance (t(23) = 2.12, p &lt; 0.05) in MB, and improved n-back performance (t(25) = 3.83, p &lt; 0.001) in the dual n-back training.Interpretation: A model-based WM training including filtering efficacy may be a promising approach to increase WM capacity and needs further investigation in randomized controlled studies.
Green Synthesis: An Eco-friendly Route for the Synthesis of Iron Oxide Nanoparticles
Authors: Priya  , Naveen  , Kaur Kamaljit , Sidhu Amanpreet K. 
Published: June 2021

Green approach has received major attention for the synthesis of metal oxide nanoparticles. One such metal oxide nanoparticles are iron oxide nanoparticles (IONPs). IONPs have fetched a great deal of interest in recent era because of their magnetic nature, as they can be easily recovered from the reaction mixture by applying an external magnetic field. Although, a variety of chemical and physical methods of synthesis are known, green synthesis is safer, sustainable and biologically acceptable. Plants and microbes are the main biological materials used for the green synthesis. In present review, the synthesis of IONPs by using plants, bacteria, fungi and algae have been highlighted. IONPs produced by plants, fungi, bacteria and algae usually falls in 1–100 nm range and are of distinct shapes like cubic, tetragonal crystalline, spherical, cylindrical, elliptical, octahedral, orthorhombic, hexagonal rods, nanosphere and quasi spherical. Furthermore, these biomaterials play role of reducing, capping, stabilizing and fabricating agents in green synthesis of nanoparticles. The review put forward a comprehensive report of various routes used for synthesizing IONP, biologically. Intuition into the procedures for synthesis of nanoparticles will help to nourish our learning in the area of nanotechnology.
Movement-Related Cortical Potentials in Embodied Virtual Mirror Visual Feedback
Authors: Garipelli Gangadhar , Rossy Tamara , Perez-Marcos Daniel , Jöhr Jane , Diserens Karin 
Published: June 2021

Background:Mirror therapy is thought to drive interhemispheric communication, resulting in a balanced activation. We hypothesized that embodied virtual mirror visual feedback (VR-MVF) presented on a computer screen may produce a similar activation. In this proof-of-concept study, we investigated differences in movement-related cortical potentials (MRCPs) in the electroencephalogram (EEG) from different visual feedback of user movements in 1 stroke patient and 13 age-matched adults.Methods:A 60-year-old right-handed (Edinburgh score &gt;95) male ischemic stroke [left paramedian pontine, National Institutes of Health Stroke Scale (NIHSS) = 6] patient and 13 age-matched right-handed (Edinburgh score &gt;80) healthy adults (58 ± 9 years; six female) participated in the study. We recorded 16-electrode electroencephalogram (EEG), while participants performed planar center-out movements in two embodied visual feedback conditions: (i) direct (movements translated to the avatar's ipsilateral side) and (ii) mirror (movements translated to the avatar's contralateral side) with left (direct left/mirror left) or right (direct right/mirror right) arms.Results:As hypothesized, we observed more balanced MRCP hemispheric negativity in themirror rightcompared to thedirect rightcondition [statistically significant at the FC4 electrode; 99.9% CI, (0.81, 13)]. MRCPs in the stroke participant showed reduced lateralized negativity in thedirect left(non-paretic) situation compared to healthy participants. Interestingly, the potentials were stronger in themirror left(non-paretic) compared todirect leftcase, with significantly more bilateral negativity at FC3 [95% CI (0.758 13.2)] and C2 [95% CI (0.04 9.52)].Conclusions:Embodied mirror visual feedback is likely to influence bilateral sensorimotor cortical subthreshold activity during movement preparation and execution observed in MRCPs in both healthy participants and a stroke patient.
Fixed-Life or Rechargeable Battery for Deep Brain Stimulation: Preference and Satisfaction in Chinese Patients With Parkinson's Disease
Authors: Qiu Xian , Peng Tingting , Lin Zhengyu , Zhu Kaiwen , Wang Yuhan , Sun Bomin , Ashkan Keyoumars , Zhang Chencheng , Li Dianyou 
Published: June 2021

Introduction: DBS is a widely used therapy for PD. There is now a choice between fixed-life implantable pulse generators (IPGs) and rechargeable IPGs, each having advantages and disadvantages. This study aimed to evaluate the preference and satisfaction of Chinese patients with Parkinson's disease (PD) who were treated with deep brain stimulation (DBS).Materials and Methods: Two hundred and twenty PD patients were treated with DBS and completed a self-reported questionnaire to assess their long-term satisfaction and experience with the type of battery they had chosen and the key factors affecting these choices. The survey was performed online and double-checked for completeness and accuracy.Results: The median value of the postoperative duration was 18 months. The most popular way for patients to learn about DBS surgery was through media (79/220, 35.9%) including the Internet and television programs. In total, 87.3% of the DBS used rechargeable IPGs (r-IPG). The choice between rechargeable and non-rechargeable IPGs was significantly associated with affordability (χ(1)2 = 19.13, p &lt; 0.001). Interestingly, the feature of remote programming significantly affected patients' choices between domestic and imported brands (χ(1)2 = 16.81, p &lt; 0.001). 87.7% of the patients were satisfied with the stimulating effects as well as the implanted device itself. 40.6% of the patients with r-IPGs felt confident handling devices within 1 week after discharge. More than half of the patients checked their batteries every week. The mean interval for battery recharge was 4.3 days. 57.8% of the patients spent around 1 h recharging, and 71.4% of them recharged the battery independently.Conclusions: Most patients were satisfied with their choice of IPGs. The patients' economic status and the remote programming function of the device were the two most critical factors in their decision. The skill of recharging the IPG was easy to master for most patients.