bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-imagining care transitions for people with dementia and complex support needs in residential aged care: using co-designed sensory objects and a focused ethnography to recognise micro transitions
Authors: Smith Louisa , Phillipson Lyn , Knight Pat 
Published: April 2021

AbstractThe concept of transition is often used in health and lifecourse research to understand a significant movement from one state or place to another. While people with dementia experience more major transitions than their peers, they are often excluded from transitional care research. This study set out to develop meaningful transitional supports for people with dementia and complex support needs who were undertaking a significant planned geographical transition from their current residential aged care facility to a new purpose-built facility. Using the language of complex support needs acknowledges that participants in this study have a breadth and depth of need, including cognitive, physical, psycho-social and communication impairmentsandsocial and cultural disadvantage associated with ageing, institutionalisation and social isolation. To support their move, Participatory Action Research was used to support the co-creation of transitional objects (personalised scarves and blankets) with 15 people with dementia, their families and care staff. Whilst these objects were useful in supporting transition, it was not in the way we imagined. Whilst our initial focus had been on supporting a significant geographical transition, rather it was four types of micro transitions in which the transitional objects were used: small physical transitions (from one place to another); social transitions (entering or exiting personal interactions); activity transitions (moving between activities); and time travel (moving between different times). Reimagining transitions from the perspective of people with dementia and complex support needs involves the recognition of the need for supports for micro as well as macro transitions. Personalised objects to support these everyday micro transitions have the potential to make the lives of people with dementia and complex support needs more manageable, meaningful and comprehensible. Reimagining transitions in dementia in this way helps us reimagine dementia itself, as a constantly fluid, dynamic and responsive series of moments which also has implications for the re-imagination of dementia care.
Silence matters: The role of pauses during dyadic maternal and paternal vocal interactions with preterm and full-term infants
Authors: KIEPURA Eliza , NIEDŹWIECKA Alicja , KMITA Grażyna 
Published: April 2021

AbstractThis study examined the characteristics of the vocal behaviors of parents and preterm infants, as compared to their term-born peers, at three months of age. Potential links between specific features of parental IDS and infants’ vocal activity were also sought. We analyzed the frequencies and durations of vocalizations and pauses during the dyadic interactions of 19 preterm and 19 full-term infants with their mothers and fathers. The results showed that the duration of the vocalizations was shorter for the preterm than for the full-term infants, regardless of the interactive partner. Mothers vocalized more frequently and for a longer time than fathers, regardless of the group, but only the frequency of paternal utterances was significantly and positively correlated with the frequency and duration of infant vocalizations. Frequent conversational pauses of a relatively short total duration seemed to be related to more active infants’ vocal participation, regardless of prematurity and parent gender.
Porosity in Conformal Dynamical Systems
Authors: CHOUSIONIS VASILEIOS , URBAŃSKI MARIUSZ 
Published: April 2021

AbstractIn this paper we study various aspects of porosities for conformal fractals. We first explore porosity in the general context of infinite graph directed Markov systems (GDMS), and we show that their limit sets are porous in large (in the sense of category and dimension) subsets. We also provide natural geometric and dynamic conditions under which the limit set of a GDMS is upper porous or mean porous. On the other hand, we prove that if the limit set of a GDMS is not porous, then it is not porous almost everywhere. We also revisit porosity for finite graph directed Markov systems, and we provide checkable criteria which guarantee that limit sets have holes of relative size at every scale in a prescribed direction.We then narrow our focus to systems associated to complex continued fractions with arbitrary alphabet and we provide a novel characterisation of porosity for their limit sets. Moreover, we introduce the notions of upper density and upper box dimension for subsets of Gaussian integers and we explore their connections to porosity. As applications we show that limit sets of complex continued fractions system whose alphabet is co-finite, or even a co-finite subset of the Gaussian primes, are not porous almost everywhere, while they are uniformly upper porous and mean porous almost everywhere.We finally turn our attention to complex dynamics and we delve into porosity for Julia sets of meromorphic functions. We show that if the Julia set of a tame meromorphic function is not the whole complex plane then it is porous at a dense set of its points and it is almost everywhere mean porous with respect to natural ergodic measures. On the other hand, if the Julia set is not porous then it is not porous almost everywhere. In particular, if the function is elliptic we show that its Julia set is not porous at a dense set of its points.
Pediatric sarcoma survivorship: A call for a developmental cascades approach
Authors: Fantozzi Peter M. , Sprint Gina , Medina Anna Marie 
Published: April 2021

AbstractSurvivors of pediatric sarcomas often experience greater psychological and psychosocial difficulties than their non-afflicted peers. We consider findings related to poorer outcomes from a developmental cascade perspective. Specifically, we discuss how physical, neurocognitive, psychological, and psychosocial costs associated with pediatric sarcomas and their treatment function transactionally to degrade well-being in long-term pediatric sarcoma survivors. We situate the sarcoma experience as a broad developmental threat – one stemming from both the presence and treatment of a life-imperiling disease, and the absence of typical childhood experiences. Ways in which degradation in one developmental domain spills over and effects other domains are highlighted. We argue that the aggregate effect of these cascades is two-fold: first, it adds to the typical stress involved in meeting developmental milestones and navigating developmental transitions; and second, it deprives survivors of crucial coping strategies that mitigate these stressors. This position suggests specific moments of intervention and raises specific hypotheses for investigators to explore.
A possible portrait of Ptolemy I from Dedoplis Gora in Caucasian Iberia (Georgia)
Authors: Gagoshidze David 
Published: April 2021

Abstract:In 2017, during the archaeological excavations of room N24 of the Palace of Dedoplis Gora (Caucasian Iberia, Georgia), built in the 2nd–1st c. BCE, fragments of a small statuette carved from bone were discovered. The statuette is a miniature sphinx with a human head and may have been an element of furniture. The male head is adorned with the nemes, a headdress worn by pharaohs. In this article, I suggest that the head of the sphinx may portray Ptolemy I Soter, the first king of Ptolemaic Egypt. Some scholars believe that artifacts containing Ptolemaic portraits came to Georgia among diplomatic gifts sent by Mark Antony to Pharnabazos II, for it was he who had close relationships with the Ptolemaic court. In my opinion the bone sphinx with the head of Ptolemy I appeared in Caucasian Iberia together with these items.
Chromospheric Heating by Magnetohydrodynamic Waves and Instabilities
Authors: Srivastava A. K. , Ballester J. L. , Cally P. S. , Carlsson M. , Goossens M. , Jess D. B. , Khomenko E. , Mathioudakis M. , Murawski K. , Zaqarashvili T. V. 
Published: April 2021

AbstractThe importance of the chromosphere in the mass and energy transport within the solar atmosphere is now widely recognized. This review discusses the physics of magnetohydrodynamic waves and instabilities in large‐scale chromospheric structures as well as in magnetic flux tubes. We highlight a number of key observational aspects that have helped our understanding of the role of the solar chromosphere in various dynamic processes and wave phenomena, and the heating scenario of the solar chromosphere is also discussed. The review focuses on the physics of waves and invokes the basics of plasma instabilities in the context of this important layer of the solar atmosphere. Potential implications, future trends and outstanding questions are also delineated.
Circulation and Cross‐Shelf Exchanges in the Northern Shelf Region of the Southwestern Atlantic: Kinematics
Authors: Combes Vincent , Matano Ricardo P. , Palma Elbio D. 
Published: April 2021

AbstractA high‐resolution ocean model is used to characterize the circulation and cross‐shelf exchanges in the Brazilian/Uruguayan portion of the southwestern Atlantic shelf. Cross‐shelf exchanges are strongly modulated by the bottom topography. There is ∼1.2 Sv of on‐shelf transport between 21°S and 25.2°S, and ∼1.6 Sv of off‐shelf transport between 35°S and 25.2°S. North of 25.2°S, the cross‐shelf exchanges show a two‐layer structure with an off‐shelf flow in the upper 50m and on‐shelf flow deep below. A Lagrangian diagnostic shows that ∼0.15 Sv of deep waters from the Brazil Current (z > 200 m) are injected into the shelf. Mixing with ambient waters produces a spicier (warmer and saltier) water mass, which is ejected into the open ocean in the southern region. Backward in‐time particle's trajectories analysis reveals that 95% of the southward shelf transport at 32°S originates in the open ocean at 22°S. Our model diagnostics show that there is a very limited connectivity between the shelf regions north and south of Cabo Frio. Correlation analysis shows no significant influence of El Niño Southern Oscillation (ENSO) and Southern Annular Mode (SAM) on the time variability of the cross‐shelf transport. Cross‐shelf transports, however, are significantly correlated with the local wind stress variability.
Correlating Apollo Soil Mineralogical Data With Kaguya Spectral Data for a Global Mineralogical Classification
Authors: Sun Lingzhi , Lucey Paul G. , Taylor G. Jeffrey 
Published: April 2021

AbstractAlthough lunar soils contain rock and mineral components from the breakdown of a mixture of rock types, a classification based on the abundances of the major silicate minerals plagioclase, olivine, low‐Ca pyroxene (LCP) and high‐Ca pyroxene can be used to evaluate the major compositional classes that are represented within a given soil. We studied the compositional classes for Apollo 15, 16, and 17 soil samples based on the mineral modal abundances derived by X‐ray diffraction (XRD). Using the XRD results as a ground truth, we determined the compositional classes of the Apollo 15, 16, and 17 sampling stations using mineral maps from the Kaguya Multiband Imager (MI), then mapped areas having compositional classes similar to the sampling stations on regional and global scales. Global distribution of compositional classes was also mapped using MI mineral maps, and the major compositional classes of lunar nonmare surfaces are noritic anorthosite (40%), anorthositic norite (24%), and anorthosite (23%). Our maps show that the lunar highlands and the South Pole‐Aitken (SPA) basin are enriched with noritic materials, indicating the widespread occurrence of LCP‐rich and olivine‐poor assemblages. In contrast to the SPA basin and the highlands, the basin rings of Serenitatis, Crisium, Humorum, Nectaris, Orientale, and Hertzsprung exhibit higher olivine/pyroxene ratios (>2), and we interpret this signature as reflecting a contribution from olivine‐rich upper mantle components.
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer
Authors: Silva Vera L. , Saxena Jayeta , Nicolini Francesco , Hoare Joseph I. , Metcalf Stephen , Martin Sarah A. , Lockley Michelle 
Published: April 2021

AbstractHigh-grade serous cancer (HGSC) accounts for ~67% of all ovarian cancer deaths. Although initially sensitive to platinum chemotherapy, resistance is inevitable and there is an unmet clinical need for novel therapies that can circumvent this event. We performed a drug screen with 1177 FDA-approved drugs and identified the hydroxyquinoline drug, chloroxine. In extensive validation experiments, chloroxine restored sensitivity to both cisplatin and carboplatin, demonstrating broad synergy in our range of experimental models of platinum-resistant HGSC. Synergy was independent of chloroxine’s predicted ionophore activity and did not relate to platinum uptake as measured by atomic absorption spectroscopy. Further mechanistic investigation revealed that chloroxine overrides DNA damage tolerance in platinum-resistant HGSC. Co-treatment with carboplatin and chloroxine (but not either drug alone) caused an increase in γH2AX expression, followed by a reduction in platinum-induced RAD51 foci. Moreover, this unrepaired DNA damage was associated with p53 stabilisation, cell cycle re-entry and triggering of caspase 3/7-mediated cell death. Finally, in our platinum-resistant, intraperitoneal in vivo model, treatment with carboplatin alone resulted in a transient tumour response followed by tumour regrowth. In contrast, treatment with chloroxine and carboplatin combined, was able to maintain tumour volume at baseline for over 4 months. In conclusion, our novel results show that chloroxine facilitates platinum-induced DNA damage to restore platinum sensitivity in HGSC. Since chloroxine is already licensed, this exciting combination therapy could now be rapidly translated for patient benefit.
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis
Authors: Feng Lifeng , Chen Miaoqin , Li Yiling , Li Muchun , Hu Shiman , Zhou Bingluo , Zhu Liyuan , Yu Lei , Zhou Qiyin , Tan Linghui , An Huimin , Wang Xian , Jin Hongchuan 
Published: April 2021

Abstractp62/SQSTM1 is frequently up-regulated in many cancers including hepatocellular carcinoma. Highly expressed p62 promotes hepato-carcinogenesis by activating many signaling pathways including Nrf2, mTORC1, and NFκB signaling. However, the underlying mechanism for p62 up-regulation in hepatocellular carcinoma remains largely unclear. Herein, we confirmed that p62 was up-regulated in hepatocellular carcinoma and its higher expression was associated with shorter overall survival in patients. The knockdown of p62 in hepatocellular carcinoma cells decreased cell growth in vitro and in vivo. Intriguingly, p62 protein stability could be reduced by its acetylation at lysine 295, which was regulated by deacetylase Sirt1 and acetyltransferase GCN5. Acetylated p62 increased its association with the E3 ligase Keap1, which facilitated its poly-ubiquitination-dependent proteasomal degradation. Moreover, Sirt1 was up-regulated to deacetylate and stabilize p62 in hepatocellular carcinoma. Additionally, Hepatocyte Sirt1 conditional knockout mice developed much fewer liver tumors after Diethynitrosamine treatment, which could be reversed by the re-introduction of exogenous p62. Taken together, Sirt1 deacetylates p62 at lysine 295 to disturb Keap1-mediated p62 poly-ubiquitination, thus up-regulating p62 expression to promote hepato-carcinogenesis. Therefore, targeting Sirt1 or p62 is a reasonable strategy for the treatment of hepatocellular carcinoma.
THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the progression of esophageal squamous cell carcinoma
Authors: Cheng Jiwei , Ma Haibo , Yan Ming , Xing Wenqun 
Published: April 2021

AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in the digestive system with a high incidence and poor prognosis. Long non-coding RNAs (LncRNA) have been reported to be closely associated with the occurrence and development of various human cancers. Data from GSE89102 shows an increase of THAP9-AS1 expression in ESCC. However, its functions and mechanisms underlying ESCC progression remain to be investigated. In this study, we found that THAP9-AS1 was overexpressed in ESCC tissues and cells. High THAP9-AS1 expression was positively correlated with tumor size, TNM stage, lymph node metastasis, and worse prognosis. Functionally, depletion of THAP9-AS1 suppressed cell proliferation, migration, and invasion, while enhanced apoptosis in vitro. Consistently, knockdown of THAP9-AS1 inhibited xenograft tumor growth in vivo. Mechanistically, THAP9-AS1 could serve as a competing endogenous RNA (ceRNA) for miR-133b, resulting in the upregulation of SOX4. Reciprocally, SOX4 bound to the promoter region of THAP9-AS1 to activate its transcription. Moreover, the anti-tumor property induced by THAP9-AS1 knockdown was significantly impaired due to miR-133b downregulation or SOX4 overexpression. Taken together, our study reveals a positive feedback loop of THAP9-AS1/miR-133b/SOX4 to facilitate ESCC progression, providing a potential molecular target to fight against ESCC.
Mint3 depletion-mediated glycolytic and oxidative alterations promote pyroptosis and prevent the spread of Listeria monocytogenes infection in macrophages
Authors: Uematsu Takayuki , Tsuchiya Kohsuke , Kobayashi Noritada , Seiki Motoharu , Inoue Jun-ichiro , Kaneko Shuichi , Sakamoto Takeharu 
Published: April 2021

AbstractListeria monocytogenes (LM) infection induces pyroptosis, a form of regulated necrosis, in host macrophages via inflammasome activation. Here, we examined the role of Mint3 in macrophages, which promotes glycolysis via hypoxia-inducible factor-1 activation, during the initiation of pyroptosis following LM infection. Our results showed that Mint3-deficient mice were more resistant to lethal listeriosis than wild-type (WT) mice. Additionally, the mutant mice showed higher levels of IL-1β/IL-18 in the peritoneal fluid during LM infection than WT mice. Moreover, ablation of Mint3 markedly increased the activation of caspase-1, maturation of gasdermin D, and pyroptosis in macrophages infected with LM in vitro, suggesting that Mint3 depletion promotes pyroptosis. Further analyses revealed that Mint3 depletion upregulates inflammasome assembly preceding pyroptosis via glycolysis reduction and reactive oxygen species production. Pharmacological inhibition of glycolysis conferred resistance to listeriosis in a Mint3-dependent manner. Moreover, Mint3-deficient mice treated with the caspase-1 inhibitor VX-765 were as susceptible to LM infection as WT mice. Taken together, these results suggest that Mint3 depletion promotes pyroptosis in host macrophages, thereby preventing the spread of LM infection. Mint3 may serve as a target for treating severe listeriosis by inducing pyroptosis in LM-infected macrophages.
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
Authors: Beatty Alexander , Singh Tanu , Tyurina Yulia Y. , Tyurin Vladimir A. , Samovich Svetlana , Nicolas Emmanuelle , Maslar Kristen , Zhou Yan , Cai Kathy Q. , Tan Yinfei , Doll Sebastian , Conrad Marcus , Subramanian Aravind , Bayır Hülya , Kagan Valerian E. , Rennefahrt Ulrike , Peterson Jeffrey R. 
Published: April 2021

AbstractFerroptosis is associated with lipid hydroperoxides generated by the oxidation of polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 (GPX4) and GPX4 inhibitors induce ferroptosis. However, the therapeutic potential of triggering ferroptosis in cancer cells with polyunsaturated fatty acids is unknown. Here, we identify conjugated linoleates including α-eleostearic acid (αESA) as ferroptosis inducers. αESA does not alter GPX4 activity but is incorporated into cellular lipids and promotes lipid peroxidation and cell death in diverse cancer cell types. αESA-triggered death is mediated by acyl-CoA synthetase long-chain isoform 1, which promotes αESA incorporation into neutral lipids including triacylglycerols. Interfering with triacylglycerol biosynthesis suppresses ferroptosis triggered by αESA but not by GPX4 inhibition. Oral administration of tung oil, naturally rich in αESA, to mice limits tumor growth and metastasis with transcriptional changes consistent with ferroptosis. Overall, these findings illuminate a potential approach to ferroptosis, complementary to GPX4 inhibition.
HP1 drives de novo 3D genome reorganization in early Drosophila embryos
Authors: Zenk Fides , Zhan Yinxiu , Kos Pavel , Löser Eva , Atinbayeva Nazerke , Schächtle Melanie , Tiana Guido , Giorgetti Luca , Iovino Nicola 
Published: April 2021

AbstractFundamental features of 3D genome organization are established de novo in the early embryo, including clustering of pericentromeric regions, the folding of chromosome arms and the segregation of chromosomes into active (A-) and inactive (B-) compartments. However, the molecular mechanisms that drive de novo organization remain unknown1,2. Here, by combining chromosome conformation capture (Hi-C), chromatin immunoprecipitation with high-throughput sequencing (ChIP–seq), 3D DNA fluorescence in situ hybridization (3D DNA FISH) and polymer simulations, we show that heterochromatin protein 1a (HP1a) is essential for de novo 3D genome organization during Drosophila early development. The binding of HP1a at pericentromeric heterochromatin is required to establish clustering of pericentromeric regions. Moreover, HP1a binding within chromosome arms is responsible for overall chromosome folding and has an important role in the formation of B-compartment regions. However, depletion of HP1a does not affect the A-compartment, which suggests that a different molecular mechanism segregates active chromosome regions. Our work identifies HP1a as an epigenetic regulator that is involved in establishing the global structure of the genome in the early embryo.
Crystal, spectroscopic and quantum mechanics studies of Schiff bases derived from 4-nitrocinnamaldehyde
Authors: Ani Friday E. , Ibeji Collins U. , Obasi Nnamdi L. , Kelani Monsuru T. , Ukogu Kingsley , Tolufashe Gideon F. , Ogundare Segun A. , Oyeneyin Oluwatoba E. , Maguire Glenn E. M. , Kruger Hendrik G. 
Published: April 2021

AbstractTwo Schiff bases, (E)-1-(4-methoxyphenyl)-N-((E)-3-(4-nitrophenyl)allylidene)methanamine (compound 1) and (E)-N-((E)-3-(4-nitrophenyl)allylidene)-2-phenylethanamine (compound 2) have been synthesized and characterized using spectroscopic methods; time of flight MS, 1H and 13C NMR, FT-IR, UV–VIS, photoluminescence and crystallographic methods. The structural and electronic properties of compounds 1 and 2 in the ground state were also examined using the DFT/B3LYP functional and 6-31 + G(d,p) basis set, while the electronic transitions for excited state calculations were carried out using the TD-DFT/6-31 + G(d,p) method. The Schiff base compounds, 1 and 2 crystallized in a monoclinic crystal system and the P21/c space group. The emission spectra of the compounds are attributed to conjugated π-bond interaction while the influence of the intra-ligand charge transfer resulted in a broad shoulder for 1 and a double emission peak for 2. The calculated transitions at 450 and 369 nm for 1 and 2 respectively are in reasonable agreement with the experimental results. The higher values of dipole moment, linear polarizability and first hyperpolarizability of 1, suggest a better optical property and better candidate for the development of nonlinear optical (NLO) materials.