bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association of Perioperative Glycemic control with Post-operative wound Infection after Coronary Artery Bypass Grafting in Veterans with Diabetes Mellitus
Authors: Elgudin Yakov , Deo Salil V , Rubelowsky Joseph , Cmolik Brian 
Published: December 2021

Abstract
Introduction: After coronary artery bypass (CABG), diabetes mellitus is associated with increased risk of infection. We model the inter-relationship of pre- and post-operative glycemic control and their composite influence on post-operative wound infection. Methods: 2,899 Veterans that underwent isolated CABG were stratified (Group I: < 8%, Group II: 8 - 10%, Group III: > 10%) according to preoperative HbA1c levels. We obtained the median blood sugar level (BSL) on post-operative days 0 - 4 (POD) and compared trends in BSL readings according to HbA1c groups. We fit a multi-variable random effects mixed model to understand the odds (OR) of developing postoperative mediastinitis. A two-stage joint model was fit to evaluate the adjusted hazard (HR) of pre-operative HbA1c, post-operative BSL and clinical factors on 90-day readmission for infection. Results: In groups I, II, and III had 66%, 25% and 9% patients respectively. In 148,810 post-operative BSL readings, median BSL values peaked at POD 2 (145 mg/dl). In group III, 29% BSL reading was above the recommended limit (< 180 mg/dl). Group III (OR 3.5; p < 0.01) and COPD (OR 2.51; p < 0.01) were associated with higher rates of mediastinitis. Groups II (HR 1.4; p = 0.01) and III (HR 1.5; p = 0.04) were associated with increased risk for 90-day readmission for infection. Post-operative blood sugar levels (p = 0.5) were not associated with increased risk for wound infection at 90 days. Conclusion: Among Veterans undergoing coronary artery bypass, a large proportion had HbA1c levels > 8%. In the post-operative period, 22% of the blood sugar readings are higher than 180 mg/dl. Preoperative HbA1c (rather than postoperative glycemic control) is associated with higher rates of deep sternal wound infection.
Scaling Behavior of Sub-100 nm InAlN/GaN HEMTs on Silicon for RF Applications
Authors: Cui Peng , Zeng Yuping 
Published: December 2021

Abstract
Due to the low cost and the scaling capability of Si substrate, InAlN/GaN high-electron-mobility transistors (HEMTs) on silicon substrate have attracted more and more attentions. In this paper, a high-performance 50-nm-gate-length InAlN/GaN HEMT on Si with a high on/off current (Ion/Ioff) ratio of 7.28 × 106, an average subthreshold swing (SS) of 72 mV/dec, a low drain-induced barrier lowing (DIBL) of 88 mV, an off-state three-terminal breakdown voltage (BVds) of 36 V, a current/power gain cutoff frequency (fT/fmax) of 140/215 GHz, and a Johnson’s figure-of-merit (JFOM) of 5.04 THz∙V is simultaneously demonstrated. The device extrinsic and intrinsic parameters are extracted using equivalent circuit model, which is verified by the good agreement between simulated and measured S-parameter values. Then the scaling behavior of InAlN/GaN HEMTs on Si is predicted using the extracted extrinsic and intrinsic parameters of devices with different gate lengths (Lg). It presents that a fT/fmax of 230/327 GHz can be achieved when Lg­ scales down to 20 nm with the technology developed in the study, and an improved fT/fmax of 320/535 GHz can be achieved on a 20-nm-gate-length InAlN/GaN HEMT with regrown ohmic contact technology and 30% decreased parasitic capacitance. This study confirms the feasibility of further improvement of InAlN/GaN HEMTs on Si for RF applications.
A Novel Approach to Damage Assessment in Structures Based on Artificial Neural Network Working Parallel With a Hybrid Stochastic Optimization
Authors: Tran-Ngoc H. , Khatir S , Le-Xuan T. , Viet H. Tran - , De Roeck G. , Bui-Tien T. , Wahab Magd Abdel 
Published: December 2021

Abstract
Artificial neural network (ANN) is the study of computer algorithms that can learn from experience to improve performance. ANN employs backpropagation (BP) algorithms using gradient descent (GD)-based learning methods to reduce the discrepancies between predicted and real targets. Even though these differences are considerably decreased after each iteration, the network may still face major risks of being entrapped in local minima if complex error surfaces contain too numerous the best local solutions. To overcome those drawbacks of ANN, numerous researchers have come up with solutions to local minimum prevention by choosing a beneficial starting position that relies on the global search capability of other algorithms. This strategy possibly assists the network in avoiding the first local minima. However, a network often has many local bests widely distributed. Hence, the solution of choosing good starting points may no further be beneficial because the particles are probably entrapped in other local optimal solutions throughout the process of looking for the global best. Therefore, in this work, a novel ANN working parallel with the stochastic search capacity of evolutionary algorithms, is proposed. Additionally, to increase the efficiency of the global search capacity, a hybrid of particle swarm optimization and genetic algorithm (PSOGA) is applied during the process of seeking the best solution, which effectively guarantees to assist the network of ANN in escaping from local minima. This strategy gains both benefits of GD techniques as well as the global search capacity of PSOGA that possibly solves the local minima issues thoroughly. The effectiveness of ANNPSOGA is assessed using both numerical models consisting of various damage cases (single and multiple damages) and a free-free steel beam with different damage levels calibrated in the laboratory. The results demonstrate that ANNPSOGA provides higher accuracy than traditional ANN, PSO, and other hybrid ANNs (even a higher level of noise is employed) and also considerably decreases calculational cost compared with PSO.
Interaction Between Retinol Intake and ISX rs5755368 Polymorphism in Colorectal Cancer Risk: A Case-control Study Among the Korean Population
Authors: Bui Anh Quynh , Gunathilake Madhawa , Lee Jeonghee , Oh Jae Hwan , Chang Hee Jin , Sohn Dae Kyung , Shin Aesun , Kim Jeongseon 
Published: December 2021

Abstract
There is limited evidence about the interaction between retinol intake and the intestine-specific homeobox (ISX) rs5755368 polymorphism in colorectal cancer (CRC) risk. We conducted a hospital-based case-control study to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. First, to identify the association between dietary retinol and CRC risk, we recruited 923 CRC patients and 1846 controls. Dietary retinol intake was assessed using a semiquantitative food frequency questionnaire. For genetic analysis, genotype data were available for 1419 patients (600 cases and 819 controls) out of the total study population. ISX rs5755368 genotyping was performed using an Illumina MEGA-Expanded Array. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression models. Retinol intake was inversely associated with the development of CRC (OR = 0.49; 95% CI = 0.37–0.63) after adjusting for confounders. Patients with homozygous AA genotype of the ISX rs5755368 polymorphism were less likely to have CRC risk than subjects carrying the G allele (AG+GG) (OR = 0.76; 95% CI = 0.58–0.99). Additionally, a 68% reduced risk of CRC was related to the highest retinol intake among those carrying the rs5755368 AA genotype compared to the risk of participants carrying the G allele consumed the lowest retinol intake (OR = 0.32; 95% CI = 0.20–0.53; P interaction=0.026). In conclusion, our study confirmed a protective role of retinol intake in CRC risk reduction. Moreover, this association was strengthened significantly among individuals carrying the homozygous AA genotype of the ISX rs5755368 polymorphism.
Mechanical and Micrography Analysis of Armour Plate Weldment Using Tungsten Inert Gas and Oxy-Acetylene Welding Methods
Authors: Osuchukwu Obinna Anayo , AGBOGU Emmanuel Obiora , GARBA Danladi King , AKINDAPO Jacob Olaitan 
Published: December 2021

Abstract
Defence Industries Corporation of Nigeria (DICON) has compared the effect of Tungsten Inert Gas (TIG) and Oxy-Acetylene welding methods on microstructural and some mechanical properties of Armour plate for the modification of military troop carriers. The optical emission spectrometer (OES) at DICON was used to analyse the chemical composition of the armour plate strip. It was then machined and cut to various test piece dimensions for both welding processes, following which the weldment samples were subjected to post-weld mechanical tests (tensile, impact, and hardness) and metallographic examination. The samples were then welded according to the procedure outlined in this study. The fundamental composition of armour plates was preserved in the samples. When compared to Oxy-Acetylene (OA) welding, Tungsten Inert Gas (TIG) welding produced better results, with an average ultimate strength (UTS) of 603.52 MPa and an impact strength of 10.53 J. In addition, the TIG analysis hardness strength for the source material, heat affected zone (HAZ), and weldment sample is 510.3, 502, and 511-HV, respectively. At x200 magnification, the micrography of the TIG weldment revealed a small coarse grain size of ferrite and larger areas of pearlite.
A Comparative Study on Chemical Characterization and Properties of Surface Active Compounds From Gram-positive Bacillus and Gram-negative Ochrobactrum Strains Utilizing Pure Hydrocarbons and Waste Mineral Lubricating Oils
Authors: Saha Ishika , Datta Sriparna , Biswas Dipa , Sengupta Dipanjan 
Published: December 2021

Abstract
Mineral lubricating oils are widely used in various industrial sectors for their applications in maintenance and functioning of machineries. However, indiscriminate dumping of these used oils has resulted in polluting the natural reservoirs which subsequently destroys ecological balance. Bacteria can emulsify or lower surface tension between phases of immiscible substrates and can acquire them as their carbon and energy sources. Such a phenomenon is mediated by synthesis of extracellular polymeric substances which can function as eminent surface active compounds based on their surfactant or emulsifying nature. The comparison between bacterial strains (Gram-positive Bacillus stratosphericus A15 and Gram-negative Ochrobactrum pseudintermedium C1) on utilisation of pure straight chain hydrocarbons, waste mineral lubricating oils as sole carbon source and chemical characterization of the synthesized surface active compounds is studied. Characterization analysis by Ultraviolet Visible spectrophotometry, Fourier-transform infrared spectroscopy, Nuclear Magnetic Resonance spectroscopy, Carbon-Hydrogen-Nitrogen analysis has given detailed structural elucidation of surface active compounds. The contrasting nature of bacterial strains in utilisation of different hydrocarbons of spindle oil was observed in Gas Chromatography-Mass Spectroscopy. The variation between both strains in utilisation of hydrocarbons can be manifested in a difference in chemical structure and properties of the synthesized surface active compounds. Scanning Electron Microscopy gives detailed insight into the difference in morphological nature of the compounds. The utilisation of these lubricating oils can address waste disposal problem and offer an economical feasible approach for bacterial synthesis of surface active compounds. Additionally, their distinctive nature and properties can maneuver applications in bioremediation of toxic environmental pollutants and as biomaterials in pharmaceutics.
Lymphatic system is the mainstream for breast cancer dissemination and metastasis revealed by single-cell lineage tracing
Authors: Miao Kai , Zhang Aiping , Shao Fangyuan , Wang Lijian , Zhang Xin , Sun Heng , Xu Jun , Zhang Jingyao , Feng Yuzhao , Guo Sen , Weng Zhihui , Wang Dong , Gao Shuai , Zhao Xiaoyang , Xu Xiaoling , Deng Chu-Xia 
Published: December 2021

Abstract
Cancer metastasis is the primary cause of cancer-related death, yet the forces that drive cancer cells through various steps and different routes to distinct target organs/tissues remain elusive. In this study, we applied a CellTag system-based single-cell lineage tracing approach to show the metastasis rate and route of breast cancer cells and their interactions with the tumour microenvironment (TME) during metastasis. The results indicate that only a small fraction of cells can intravasate from the primary site into the blood circulation, whereas more cells disseminate through the lymphatic system to different organs. Tumour cells derived from the same progenitor cell exhibit different gene expression patterns in different soils, and the cancer cell-TME communication paradigm varies significantly between primary and metastatic tumours. Furthermore, metastable cells require a prewired IL-2 expression ability to migrate in vivo. In summary, leveraging a single-cell lineage tracing system, we demonstrate that the crosstalk between tumour cells and the TME is the driving force controlling the preferential metastatic fate of cancer cells through the lymphatic system and that this metastasis can be suppressed by knockdown of IL-2.
Effect of Electric Field On Electron Mobility in Sub-100 nm InAlN/GaN High Electron Mobility Transistors
Authors: Cui Peng , Zeng Yuping 
Published: December 2021

Abstract
Electron mobility is important for electron velocity, transport current, output power, and frequency characteristics. In conventional mobility extraction methods, electron mobility is usually extracted directly from the measured gate capacitance (CG) and current-voltage characteristics. When device gate length (LG) scales to sub-100 nm, the determination of CG becomes more difficult not only for the measure equipment but also the enhanced effect from parasitic capacitance. Here in this paper, the CG extracted from high-frequency small-signal equipment circuit is used for the InAlN/GaN high electron mobility transistors (HEMTs). Electron mobility of the device with LG of 60-nm under VDS of 0.1 V and 10 V is extracted using two-dimensional scattering theory, respectively. The obtained results show that under a high electric field, the electron temperature (Te) and addition polarization charges (∆σ) increase, resulting in the enhanced polar optical phonon (POP) as well as polarization Coulomb field (PCF) scatterings and degradation of the electron mobility. This study makes it possible to improve the electron mobility by reducing Te and ∆σ for the InAlN/GaN HEMTs application.AlGaN/GaN heterostructure field-effect transistors with different gate lengths were fabricated. Based on the chosen of the Hamiltonian of the system and the additional polarization charges, two methods to calculate PCF scattering by the scattering theory were presented. By comparing the measured and calculated source-drain resistances, the influence of the different gate lengths on the PCF scattering potential was confirmed.
Melittin Regulates Iron Homeostasis as a Key Mediator of Macrophage Polarization in Rat Lumbar Spinal Stenosis
Authors: Kim Hyunseong , Hong Jin Young , Jeon Wan-Jin , Lee Junseon , Lee Yoon Jae , Ha In-Hyuk 
Published: December 2021

Abstract
BackgroundLumbar spinal stenosis (LSS) is defined as the narrowing of the spinal canal, which compresses the nerves traveling through the lower back into the legs. Inflammation is the most common cause of LSS. Chronic pain induced by nerve damage results from chronic inflammation, and the inflammation response worsens with elevated iron stores. Furthermore, macrophage polarization to the M1 (inflammatory) or M2 (anti-inflammatory) type is essential for controlling host defense or repairing tissues. However, the precise function of macrophage polarization in iron release or retention in LSS pathophysiology is not well-understood. Here, we introduce melittin to modulate macrophage polarization related to iron metabolism for LSS treatment.MethodsPrimary peritoneal macrophage were cultured in 200 or 500 ng/mL of melittin and FeSO4-containing medium for 24 h. Macrophage polarization was assessed by Immunofluorescence staining to CD86 or Arg1 antibodies. In an in vivo rat model of LSS, melittin were administered at 100 and 250 µg/kg, and in vivo effects of melittin on iron deposition-induced macrophage polarization was evaluated by immunochemistry, real time-PCR, western blot, and flow-cytometry. The locomotor functions were assessed by BBB, ladder scoring, and Von Frey test for up to 3 weeks. ResultsIn vitro experiments demonstrated that macrophages can be polarized toward an M2 phenotype after melittin treatment in iron-insulted primary macrophages. Treatment with 100 and 250 μg/kg melittin in a rat LSS model increased the proportion of M2 macrophages in the damaged spinal cord. Moreover, we found that melittin attenuated iron overload-induced M1 polarization via regulating iron metabolism-related genes in LSS rats. As a result, melittin improved locomotor recovery and stimulated axonal growth following LSS.ConclusionsMelittin can promote functional recovery in LSS models by activating M2 macrophages via controlling macrophage iron metabolism, suggesting the potential applications of melittin for treating LSS.
High Expression of Complement Component C7 Indicates Poor Prognosis of Endometrial Cancer and poor 5-year OS
Authors: Li Ruoqiao , Yue Qi 
Published: December 2021

Abstract
Background: Corpus Carcinoma is the most commonly diagnosed female cancer worldwide. However, the well-known biomarkers are not enough to meet the needs of precision medicine. Novel targets are desirable and highly valuable for improved patient survival. In this regard, we identified complement component C7 as one of the candidates based on data from the TCGA database.Method: C7 expression was examined by mRNA expression profile in 425 cases of corpus carcinoma, including grade 3 data (such as mRNA-seq, miRNA-seq, and clinical data) from 406 primary corpus carcinoma tissues and 19 normal controls from the dataset. The availability of data is demonstrated by heat maps, and the distribution of genes is demonstrated by volcanic maps. Then the value of C7 was demonstrated on the basis of genomics and clinical epidemiology respectively, confirmed by grade 3 data from TCGA. The relationship between the C7 expression and five-year survival of corpus carcinoma patients was analyzed in order to investigate the function of C7 in corpus carcinoma. Result: In our present study, we reported for the first time that C7 was an independent prognostic factor of corpus carcinoma and the 5-year survival rate of patients with high C7 expression is lower than that of patients with low C7 expressions. (p=0.02265) Conclusion: In summary, high expression of C7 may promote corpus carcinoma development. Our present study laid a foundation to help clinicians improve the identification of patients for C7 in the era of precision medicine.
Meteorological and climatic variables predict the phenology of Ixodes ricinus nymphs activity in France, accounting for habitat heterogeneity
Authors: Wongnak Phrutsamon , Jacquot Maude , Bord Séverine , Agoulon Albert , Beugnet Frédéric , Bournez Laure , Cèbe Nicolas , Chevalier Adélie , Cosson Jean-François , Dambrine Naïma , Hoch Thierry , Huard Frédéric , Korboulewsky Nathalie , Lebert Isabelle , Madouasse Aurélien , Mårell Anders , Moutailler Sara , Plantard Olivier , Pollet Thomas , Poux Valérie , René-Martellet Magalie , Vayssier-Taussat Muriel , Verheyden Hélène , Vourc’h Gwenaël , Chalvet-Monfray Karine 
Published: December 2021

Abstract
Ixodes ricinus ticks (Acari: Ixodidae) are the most important vector for Lyme borreliosis in Europe. As environmental and climate changes might affect the distribution and activity of tick populations, this study aimed to determine the effects of environmental factors, i.e., meteorological, bioclimatic, and habitat characteristics on questing activity of I. ricinus nymphs across diverse climatic types in France over an 8-year period. Questing activity was observed using a repeated removal sampling design with a cloth-dragging technique in 11 sampling sites from 7 tick observatories from 2014 to 2021 at approximately 1-month intervals, involving 631 sampling campaigns. Three phenological patterns were observed, potentially following a climatic gradient. The mixed-effects negative binomial regression revealed that observed nymph counts were driven by different interval-average meteorological variables, including one-month average temperature, previous-season average temperature, and half-year average minimum relative humidity. The interaction effects indicated that the phenology in colder climates peaked differently from that of warmer climates. Also, the land cover characteristics that support the highest baseline abundance were moderate forest fragmentation with transition borders with agricultural areas. Finally, our model could potentially be used to predict seasonal human-tick exposure risks in France that could contribute to mitigating Lyme borreliosis risks.
Generation of Efficient Terahertz Radiation by Relativistic Self-Focusing of A Cosh-Gaussian Laser Beam in A Magnetized Plasma
Authors: Purohit Gunjan , Gaur Bineet , Kothiyal Pradeep , Raizada Amita 
Published: December 2021

Abstract
This paper presents a scheme for the generation of terahertz (THz) radiation by self-focusing of a cosh-Gaussian laser beam in the magnetized and rippled density plasma, when relativistic nonlinearity is operative. The strong coupling between self-focused laser beam and pre-existing density ripple produces nonlinear current that originates THz radiation. THz radiation is produced by the interaction of the cosh-Gaussian laser beam with electron plasma wave under the appropriate phase matching conditions. Expressions for the beamwidth parameter of cosh-Gaussian laser beam and the electric vector of the THz radiation have been obtained using higher-order paraxial theory and solved numerically. The self-focusing of the cosh-Gaussian laser beam and its effect on the generated THz amplitude have been studied for specific laser and plasma parameters. Numerical study has been performed on various values of the decentered parameter, incident laser intensity, magnetic field, and relative density. The results have also been compared with the paraxial region as well as the Gaussian profile of laser beam. Numerical results suggest that the self-focusing of the cosh-Gaussian laser beam and the amplitude of THz radiation increase in the extended paraxial region compared to the paraxial region. It is also observed that the focusing of the cosh-Gaussian laser beam in the magnetized plasma and the amplitude of the THz radiation increases at higher values of the decentered parameter.