bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrophotometric analysis of crown discoloration induced by various intracanal medicaments
Authors: Parikh Amishi Amit , Nirupama D N , Naveen D N , Sindhu J , Nainan Mohan Thomas 
Published: September 2021

Aim:
The aim of the study was to assess discoloration potential of four different intracanal medicaments.

Materials and Methods:
Thirty single-rooted extracted bovine incisors were sectioned to a standardized root length, accessed, instrumented, and placed with temporary filling and cotton pellet. The specimens were divided into five groups (n = 6): Control group with no intracanal medicament and four groups with the following medicaments, i.e., calcium hydroxide (Ca(OH)2), calcium hydroxide with chlorhexidine (Ca(OH)2 with CHX), triple antibiotic paste (TAP), and silver diamine fluoride (SDF), respectively. Calorimetric evaluation, according to CIE L*a*b* system, was performed at pretreatment, on day 1, 7, 14, and 21. Data were analyzed using One-Way ANOVA and Repeated ANOVA. P <0.05 was considered statistically significant.

Results:
The greatest color change (ΔE*) was observed at day 21 in TAP group (P < 0.001) followed by SDF group (P < 0.013), whereas Ca(OH)2 and Ca(OH)2 with CHX groups did not induce visible coronal discoloration.

Conclusions:
Ca(OH)2 and Ca(OH)2 with the CHX groups showed the smallest coronal discoloration during the experimental time, whereas TAP and SDF groups showed the highest coronal discoloration.
Analysis of root and canal morphologies of maxillary second molars in a South Indian population using cone-beam computed tomography
Authors: Rosaline Hannah , Kanagasabai Arivunithi , Shaji Athira , Bose Shreya , Saeralaathan Sindhu , Ganesh Arathi 
Published: September 2021

Aim:
The aim of the present study was to analyze the morphological variations and complexities in root canal systems of the maxillary second molars in South Indian population, using cone beam computed tomography (CBCT).

Subjects and Methods:
The CBCT images of 500 participants were examined at different slice thickness of 125 micrometers. Root canal systems of the 500 maxillary second molars were analyzed according to Vertucci, HMA Ahmed et al., and Kim et al. classifications in the Indian subpopulation.

Statistical Analysis Used:
Interobserver variability was analyzed using Kappa statistics.

Results:
Among the tooth analyzed, 63% had three roots, with a single canal in each root in 65.2% tooth. About 41.8% of the tooth had fusion of mesiobuccal and distobuccal roots. The most commonly found root canal configuration was Type I (65%) according to Vertucci's classification. According to HMA Ahmed et al. classification, 67.9% tooth had the configuration of 327 MB1 DB1 P1/317 MB1 DB1 P1. Nearly 20.8% tooth had MB2 canal. The most common isthmus type was Type II (55.2%) according to Kim's classification, and the prevalence of isthmus was 2–5 mm from the root apex.

Conclusions:
The number of roots, canals, their configuration, and occurrence of isthmus has not been reported in the South Indian population. The importance of understanding the knowledge of the anatomy of teeth during the treatment of maxillary second molars would contribute to successful endodontic outcomes.
Predictive role of neutropenia under crizotinib treatment in ALK-rearranged nonsmall cell lung cancer patients
Authors: Gürsoy Pınar , Çakar Burcu , Nart Deniz , Göker Erdem 
Published: September 2021

Background:
Anaplastic lymphoma kinase (ALK)-rearranged nonsmall cell lung cancer (NSCLC) represents a molecular subgroup with high sensitivity to ALK inhibitors. Tyrosine kinase inhibitor crizotinib, an anticancer drug acting as an ALK inhibitor, has shown remarkable response in ALK-positive NSCLC. The aim of our study is to explore the adverse events (AEs) of patients on crizotinib therapy and analyze the predictability of AEs for better survival or response on NSCLC patients.

Methods:
The medical records of our ALK-positive metastatic NSCLC patients who applied between years 2013 and 2018 had been reviewed retrospectively. ALK positivity of all patients had been detected by fluorescence in situ hybridization and no other driver mutations were present. Patient demographics, performance status, smoking history, previous treatments, metastatic sites, and AEs were recorded for further analyses.

Results:
Thirty-six ALK-positive metastatic NSCLC patients were included in the study. Median follow-up was 30.1 months. Median progression-free survival (PFS) for patients who developed hepatic, cardiac, or endocrine toxicities was similar when compared to patients who did not develop. Although there was a numeric median PFS difference between patients who did develop visual disorders (18.4 months) and did not develop visual disorders (15.5 month), this was not regarded as statistically significant. However, median PFS of the patients who developed neutropenia upon crizotinib treatment (31.9 months) was found to be more favorable than the patients with normal neutrophil counts (12.8 months) (P = 0.026).

Conclusion:
Neutropenia under crizotinib treatment was found to be associated with improved PFS suggesting that neutropenia might be an important determinant in treatment and survival strategies.
Posttransplant Renal Allograft Dysfunction – A Retrospective Observational Study
Authors: Kunthara Mathew George , Sahay Manisha , Hussain Hakim Imran , Ismal Kiranmai , Vali P Sharmas , Kavadi Anuradha , Kumar B. Vikram 
Published: September 2021

Background:
In India, a large number of end-stage renal disease patients are undergoing renal replacement therapy. A successful renal transplantation relives the burden of dialysis with improved quality of life and a productive life thereafter. This also reduces the cost of health care to the government and the society. Graft dysfunction is an important cause of graft loss. The objective of this retrospective study is to evaluate the graft dysfunction and its impact on patient and graft survival.

Methods:
We did a retrospective record-based analysis of 83 cases (including both deceased and live-related renal transplants) from 2014 to 2019 who were on triple immunosuppression (tacrolimus, mycophenolate mofetil, and steroids) as maintenance therapy. Patients who had graft dysfunction, underwent graft biopsy and were analyzed subsequently.

Results:
The most common causes for graft dysfunction on biopsy were acute rejection, acute tubular injury, and calcineurin inhibitor toxicity. About 39% of the patients had infections, predominantly bacterial and viral infections. The rejections were associated with poor patient survival (statistically significant). The overall patient survival at our center after 1 year and 3 years was 88% and 84%, respectively, while the death-censored graft survival was 86% and 81%, respectively.

Conclusion:
In our center, following renal transplantation, patients had a fairly successful outcome. However, early detection and prompt management of the graft dysfunction can improve the graft and the patient survival.
Clinical Characteristics and Outcome of Novel Coronavirus Disease in Kidney Transplant Recipients
Authors: Arumugam Venkatesh , Sastry Bhagavatula V. R. H. , Solomon Dolphin J. , Gopalakrishnan Natarajan , Kannan Badri Srinivasan , Shankar P. , Alavudeen N. Sheik , Dakshinamoorthy Shivakumar , Natarajan Malathy 
Published: September 2021

Background:
Organ transplant recipients are at increased risk of infections which may result in acute graft dysfunction and death. Coronavirus disease (COVID-19) is the ongoing global infectious challenge and little is known about the impact of this novel virus in kidney transplant recipients. We here describe the clinical presentations, laboratory profile, and outcomes of 42 such patients, from a large tertiary care center in south India.

Materials and Methods:
This prospective, observational study included all renal transplant recipients with confirmed COVID-19 by reverse transcription polymerase chain reaction from the start of the outbreak till August, 2020. Clinical features at presentation, laboratory and radiological data, and outcomes were analyzed.

Results:
Forty-two patients were included in the analysis. As many as, 86.7% patients of our cohort had symptoms at presentation, with the most common symptoms being fever (52.5%), breathlessness (50%), and cough (40.5%). Significant need for respiratory support was noted in individuals with longer duration posttransplant (P < 0.03). Acute worsening of allograft function was observed in 22 (52.4%) patients. Fourteen (65%) of them had acute on chronic graft dysfunction and acute graft dysfunction was noted in 8 (35%) patients. Six patients (14.5%) died due to the disease and none of the parameters were found to be an independent predictor of mortality in regression analytic models including acute graft dysfunction (P = 0.49) or acute on chronic graft dysfunction (P = 0.07). There was no correlation between disease severity and baseline immunosuppressive agents whether tacrolimus or cyclosporine (P = 0.57) and mycophenolate mofetil or azathioprine (P = 0.91).

Conclusions:
Our largest cohort of patients from India showed higher incidence of acute graft dysfunction and significant mortality in patients with COVID-19.
Value of Ambulatory Blood Pressure Monitoring in Potential Renal Donors - A Prospective Observational Study
Authors: Parikh Mital Dipakkumar , Hegde Umapati , Rajapurkar Mohan , Gang Sishir , Konnur Abhijit , Patel Hardik 
Published: September 2021

Introduction:
Hypertension is very common among urban as well as rural population. In our donor selection policy, uncontrolled hypertension or target organ damage is a contraindication to kidney donation. Studies of blood pressure (BP) response to unilateral nephrectomy in kidney donors in short- and long-term are needed. We studied BP in kidney donors by ambulatory BP monitoring (ABPM) and the effect of unilateral nephrectomy on BP in them for 1 year following kidney donation.

Methodology:
We enrolled 80 consenting kidney donors aged between 20 and 65 years and followed them serially at pre, 6, and 12 months postkidney donation. Estimated glomerular filtration rate (eGFR) was measured using chronic kidney disease exocrine pancreatic insufficiency (CKD EPI) formula. BP was measured in the clinic (sphygmomanometer) and by ABPM (MeditechABPM05). eGFR, two-dimensional echocardiography, ophthalmological fundus examination, and 24 h proteinuria measurement were done at each visit.

Results:
There was a significant difference in predonation systolic BP by clinic and ABPM (138.07 + 5.5 vs. 117.17 + 10.2; P < 0.001) suggestive of white coat hypertension (WC) effect in 32 donors (40%) which decreased to only 21 (26.25%) donors having WC effect at 12 months of follow-up. There was masked hypertension (MH) in total 3 (3.75%) donors with sustained hypertension (SH) in 10 (12.5%) donors. BP was stable by ABPM till 1-year postdonation. Mean systolic and diastolic BP by ABPM was significantly higher in SH and MH groups as compared to WC and sustained normotensives. Baseline predonation eGFR measured by CKD-EPI was 106.0 + 12.35. eGFR decreased to 80.15 ± 15.76, i.e. 76% of the baseline eGFR. Hypertension by ABPM at baseline was associated with more decrease in the eGFR at 1 year of follow-up particularly in those with age > 50 years and higher body mass index. Proteinuria increased from the baseline value of 82.7 ± 29.94–104.07 ± 49.36 mg/day at 1 year of follow-up.

Conclusions:
ABPM provides a more accurate and reproducible estimate of BP compared to clinic BP to rule out WC hypertension and MH in kidney donors. Unilateral nephrectomy has no significant impact on kidney function or proteinuria over 1 year.
A Community-based Cross-sectional Study on Self-care and Its Role in the Management of Diabetes Among Patients with Type 2 Diabetes Mellitus
Authors: Vasu Dinesh Peraje , Kulkarni Annarao Gunderao , Gangadhar Namratha Kurunji 
Published: September 2021

Introduction:
Type 2 diabetes mellitus is one of the most common non-communicable diseases in India. Self-care practices in diabetes are essential for the control of the disease and improvement of quality of life. The objective of this study was to assess the proportion of study subjects practicing self-care practices and to study their influence on glycemic control.

Materials and Methods:
This is a community-based cross-sectional study on 400 diabetic patients selected by probability proportionate to sample size to assess the self-care practices with the help of a semistructured questionnaire after obtaining institutional ethical clearance.

Results:
Majority of the study population were males (62.75%) and belonged to the age group of 40–60 years (60.25%). About 51% of the respondents were diabetic for less than 6 years; 24% and 16% followed a healthful eating plan and exercised regularly, respectively. About 46% were regular in taking medications and 71% checked their blood sugars regularly. Only 0.5% checked their foot and inside of their foot wear regularly.

Conclusion:
Self-care practices were found to be unsatisfactory in most of the domains that were studied. As these practices are essential for the prevention of complications and to provide a better quality of life, more efforts are needed to educate the people about self-care practices.
Type 2 Diabetes Mellitus in Saudi Arabia
Authors: Tanveer Muhammad Saad , Tanveer Muhammad Hassan , Javed Mamoona 
Published: September 2021

Objectives:
To review the effectiveness of current clinical interventions and integrated care program, and the cost-effectiveness of currently available pharmaceutical interventions in the management of Type 2 Diabetes Mellitus in Saudi Arabia.

Data Sources and Methods:
A systematic search of MEDLINE, EMBASE, ScienceDirect, CENTRAL, and Google Scholar was conducted to identify the relevant articles. A detailed inclusion–exclusion criterion was developed and implemented to screen the abstracts and full-texts. We extracted study data from eligible studies into a data extraction form and categorized into various themes to answer our research question.

Study Selection and Themes:
Seventeen studies categorized into three themes were included in this review. The evidence was compiled to report the effectiveness of current clinical interventions, integrated care program, and cost-effectiveness of pharmaceutical interventions.

Conclusions:
There is strong evidence of safety and efficacy of BIAsp 30 in T2DM patients. In addition, BIAsp 30 with or without OADs is more cost-effective compared with other pharmaceutical interventions. The integrated care program is more effective in reducing HbA1c in diabetic patients compared with usual care programs; however, the evidence is small and more studies are required.

Recommendations:
Most of the available studies are small cross-sectional studies. There is a dire need to conduct extensive and high-quality studies, with the sample size representative of Saudi T2DM populations, to generate larger data with high-quality evidence to provide more robust evidence in the future.
Application Design of Web-based Computer Laboratory Inventory and Maintenance System at SMK Bhakti Anindya
Authors: Syafrizal Reza , Sarmuni Sarmuni , Aibar Rizki 
Published: September 2021

This paper describes a problem in computer laboratory maintenance and inventory. Inventory of goods in Every company or institution always has a connection with the data management process of goods / equipment owned by the company. In addition to inventory, maintenance is also very necessary in order to keep company assets under control, safe, and always maintained. For this reason, an Inventory Information System is needed as well as a maintenance system in managing the data. The results of this design are focused on managing information about the management of goods and several aspects regarding the maintenance of goods, especially in the computer laboratory of SMK Bhakti Anindya. With the implementation of the maintenance information system and laboratory inventory at Bhakti Anindya Vocational School, data management and equipment maintenance will be better.
Tulisan ini menjelaskan mengenai sebuah permasalahan dalam perawatan dan inventaris laboratorium komputer. Inventarisasi barang dalam Setiap perusahaan atau sebuah lembaga selalu memiliki keterkaitan dengan proses pengelolaan data barang / peralatan yang di miliki oleh perusahaan tersebut. Disamping inventarisasi, hal perawatan juga sangat diperlukan demi menjaga agar aset perusahaan terkontrol, aman, dan selalu terawat. Untuk itulah di butuhkan suatu Sistem Informasi Inventaris sekaligus sistem perawatannya dalam mengelola data tersebut. Hasil dari rancang bangun ini dititik beratkan pada pengelolaan informasi tentang pengelolaan barang dan beberapa aspek mengenai perawatan barang terutama pada bagian laboratorium komputer SMK Bhakti Anindya. Dengan diimplementasikannya sistem informasi Perawatan dan inventaris laboratorium di SMK Bhakti Anindya, pengelolaan data barang dan perawatan alat akan lebih baik.
Mongolia stage decoration in the socialist period
Authors: Ли Ч. 
Published: September 2021

До появления профессиональных театров в Монголии театрализованные представления, мистерии и гимны, танец Цам, церемонии в честь Майтрейи, имеющие религиозное назначение, исполнялись в монастырях Их Хурээ, Эрдэнэ Зуу и некоторых крупных монгольских храмах. Результаты данного исследования показывают, что оформление религиозных и государственных театрализованных церемоний было разработано художниками и мастерами декоративно-прикладного искусства и предназначено для демонстрации на подмостках и на площади. Все типы мистерии были основой для развития декоративно-прикладного искусства, а именно для создания одежды и аксессуаров с активным использованием дерева, кости, камня, металла, кожи, бумаги и войлока. Таким образом, традиционные народные промыслы, такие как шитье, вышивание, ткачество, аппликации, резьба, тиснение и роспись, использовались для изготовления костюмов для Цама, масок и реквизита. Этот факт доказывает, что все виды декоративно-прикладного искусства, связанные с театрализованными церемониями, являются традиционным художественным творчеством. После Народной революции 1921 года в Монголии начало развиваться современное театральное искусство, которое создало условия для развития различных творческих профессий, связанных со сценой.
Prior to the establishment of professional theaters in Mongolia, operas and hymns were performed at the Ikh Khuree, and Tsam dances and Maitreya ceremonies were held at the Ikh Khuree, Erdene Zuu, and some major Mongolian temples. The results of the research show that these works of art, religion, and state ceremonies were designed by artists and craftsmen who were trained in arts and crafts, and were designed to be placed on stage and in the square, and to create clothes and accessories. For example, using wood, bone, stone, metal, leather, paper, and felt, traditional folk crafts such as sewing, stitching, weaving, gluing, carving, embossing, weaving, and painting are used to make Tsam costumes, masks, and stage set. The fact that the Mongolian stage design is a traditional art activity proves that it was a traditional art activity. After the People's Revolution of 1921, Mongolians established modern theatrical art, which created conditions for the development of various professions created on stage. An integral part of the development of the theater is the stage design and decoration. Stage decoration can be considered as a collective work of playwrights, directors, actors, composers and stage artists.
The revival of felt art in Mongolia in the case of the artist Munkhsoyol Batsukh
Authors: Онуфриенко Д.Е. 
Published: September 2021

Объектом исследования является творчество одного из мастеров декоративно-прикладного искусства Мунхсоёла Батсуха. В статье рассмотрены вопросы истории развития войлочного искусства Монголии на протяжении веков. Показано, что традиции народных мастеров не утрачены, а активно применяются современными мастерами. В частности, возрождаются приемы, сложившиеся еще в гуннское время. В орнаментации распространены монгольские растительные и геометрические узоры, в сюжетных композициях используются образы народной мифопоэтики. В статье дан анализ трех серий работ художника — крупных ковровых изделий для торжественных правительственных церемоний, «Связь прошлого и настоящего», «Сцены охоты».
The object of the study is the work of Munkhsoyol Batsukh, one of the masters of decorative and applied art. The article considers the issues of the history of the development of the felt art of Mongolia, its development over the centuries. The author showed that the traditions of folk masters are not lost, but are actively used by modern masters. In particular, the techniques that have developed in the Hunnic times are being revived. Mongolian floral and geometric patterns are widespread in ornamentation, images of folk mythic poetics are used in plot compositions. The article analyzes three series of works by the artist — large carpets for solemn government ceremonies, “The connection between the past and the present”, “Hunting scenes”.
Mongolian works of Buddhist art in the museums of Irkutsk: general characteristics of the collections
Authors: Шинковой А.И. 
Published: September 2021

В статье дается общая характеристика монгольских буддийских коллекций в Иркутском областном художественном им. В.П. Сукачёва и Иркутском областном краеведческом музее. Показана значимость и оригинальность монгольских коллекций в музеях; приведены краткие истории их формирования и способы комплектования фондов восточными произведениями искусства. Дается сравнительный анализ коллекций; в частности, отмечается, что предметы монгольских собраний Иркутского областного художественного музея, в отличие от коллекций Иркутского областного краеведческого музея, были освящены ламами. Приводятся описания наиболее значимых монгольских экспонатов, анализируются экспонаты религиозного культа.
The article provides a general description of the Mongolian Buddhist collections in the Irkutsk Regional Art Museum named after V.I. Sukachov and the Irkutsk Regional Museum of Local Lore. The significance and originality of Mongolian collections in museums is shown; brief histories of their formation and methods of acquisition of funds with oriental works of art are given. Comparative analysis of the collections is given; in particular, it is noted that the items of the Mongolian collections of the Irkutsk Regional Art Museum, in contrast to the collections of the Irkutsk Regional Museum of Local Lore, were consecrated by lamas. Descriptions of the most significant Mongolian exhibits are given; the exhibits of the religious cult are analyzed.