bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges, Opportunities and Threats of Deep Bottoms-Up Water Injection in Heavy Oil Reservoir: Lessons Learnt from the G Field, South Oman
Authors: Behera Chaitanya , Mahajan Sandip , Annia Carlos , Harthi Mahmood , Obilaja Jane-Frances , Abri Said , Hamdoun Lana 
Published: April 2021

Abstract
This paper presents the results of a comprehensive study carried out to improve the understanding of deep bottom-up water injection, which enabled optimizing the recovery of a heavy oil field in South Oman. Understanding the variable water injection response and the scale of impact on oil recovery due to reservoir heterogeneity, operating reservoir pressure and liquid offtake management are the main challenges of deep bottoms-up water injection in heavy oil fields. The offtake and throughput management philosophy for heavy oil waterflood is not same as classical light oil. Due to unclear understanding of water injection response, sometimes the operators are tempted to implement alternative water injection trials leading to increase in the risk of losing reserves and unwarranted CAPEX sink. There are several examples of waterflood in heavy oil fields; however, very few examples of deep bottom water injection cases are available globally.
The field G is one of the large heavy oil fields in South Oman; the oil viscosity varies between 250cp to 1500cp. The field came on-stream in 1989, but bottoms-up water-injection started in 2015, mainly to supplement the aquifer influx after 40% decline of reservoir pressure. After three years of water injection, the field liquid production was substantially lower than predicted, which implied risk on the incremental reserves. Alternative water injection concepts were tested by implementing multiple water injection trials apprehending the effectiveness of the bottoms-up water injection concept. A comprehensive integrated study including update of geocellular model, full field dynamic simulation, produced water re-injection (PWRI) model and conventional field performance analysis was undertaken for optimizing the field recovery.
The Root Cause Analysis (RCA) revealed many reasons for suboptimal field performance including water injection management, productivity impairment due to near wellbore damage, well completion issues, and more importantly the variable water injection response in the field. The dynamic simulation study indicated negligible oil bank development due to frontal displacement and no water cut reversal as initial response to the water injection. Nevertheless, the significance of operating reservoir pressure, liquid offtake and throughput management impact on oil recovery cann't be precluded.
The work concludes that the well reservoir management (WRM) strategy for heavy oil field is not same as the classical light oil waterflood. Nevertheless, the reservoir heterogeneity, oil column thickness and saturation history are also important influencing factors for variable water injection response in heavy oil field.
Wireline Retrievable ESP Deployment: Observation, Challenges and Intervention
Authors: Suhaimin Fadzlan , Oritola Nasir , Fang Bo Jun , Cheong Hing Kheong , Chan Yung Khiong 
Published: April 2021

Abstract
The Offshore Field X Project comprises of greenfield scope to expand the Waterflood scheme towards delivering the peak production levels similar to those achieved in the 1990s. Although various artificial lift systems have been successfully deployed in Brunei Shell Petroleum, offshore ESP installation, especially on this scale, is a first and a new journey for the company and its Offshore Assets in which gas lift was predominantly the artificial lift method.
The first offshore ESP well was only installed and kicked off in 2017 as part of the Field X Project. As wells are located offshore, cost, resources and logistics remain a challenge for well interventions. With a high workover cost associated with conventional ESP change out, a technology trial was embarked upon to install wireline retrievable ESP systems.
A total of 4 out of the 22 ESP wells were approved to be installed and completed with wireline retrievable ESP system on a pilot basis. The business goal was to prove the production deferment reduction and cost advantage for a failed ESP replacement. A critical selection process was followed as well as FAT/industry benchmarking in order to land on WRESP decision for the pilot. System installation and commissioning of the wells was completed by June 2019, however a series of start-up problems were encountered, leading to an intervention requirement to rectify 1 well. Job planning for this intervention was not straight forward and was classified as a high-risk job requiring regulator's approval. Rigorous logistics planning, integration of various vendors, detailed workflow analysis, intervention equipment stack up and modifications were among the planning scope conducted.
This paper captures details of the deployment value proposition, case success definition and challenges faced in ensuring all the installed WRESPs are up and running to enable the pilot performance proper evaluation. As no full workover has been executed yet due to the limited operating period, a lifecycle comparison between WL retrievable and conventional ESPs has not been done yet. Once sufficient performance data is available, a detailed study will be conducted to assess the performance of the WRESP system. This analysis will then conclude the technology trial and may change the future of ESP wells in BSP and Shell global.
Neurobehavioral dimensions of Prader Willi Syndrome: Relationships between sleep disturbance and psychotic experiences
Authors: Zhang Zizhao , Vajdi Ariana , Kushan-Wells Leila , Huang Zhengyi Sissi , Pacheco-Hansen Laura , Roof Elizabeth , Holland Anthony , Port Allison M. , Gur Ruben C. , Bearden Carrie E. 
Published: April 2021

Abstract
Background

Prader Willi Syndrome (PWS) is a genetic disorder caused by the absence of expression of the paternal copies of maternally imprinted gene(s) located at 15q11–q13. While the physical and medical characteristics of PWS, including short stature, hyperphagia and endocrine dysfunction are well-characterized, systematic investigation of the long-recognized psychiatric manifestations has been recent.
Methods

Here, we report on the first remote (web-based) assessment of neurobehavioral traits, including psychotic-like experiences (Prodromal Questionnaire-Brief Version; PQ-B) and sleep behavior (Pittsburgh Sleep Quality Index), in a cohort of 127 participants with PWS, of whom 48% had a paternal deletion, 36% uniparental disomy, 2.4% an imprinting mutation and 13% unknown mutation (mean age 19.2 years+/-8.4 years; 55.2% female). We aimed to identify the most informative variables that contribute to psychosis risk symptoms. Multiple domains of cognition (accuracy and speed) were also assessed in a subset of PWS participants (N = 39) using the Penn Computerized Neurocognitive Battery (Penn-CNB).
Results

Individuals with PWS reported a range of psychotic-like symptoms, with over half reporting cognitive disorganization (61%) and suspiciousness (51%). Sleep disturbance, particularly the reasons for sleep difficulty, was most strongly associated with distress related to psychotic-like symptoms. Regarding cognition, individuals with PWS showed the most prominent deficits in accuracy on measures of social cognition involving faces, namely Face Memory, Age Differentiation and Emotion Recognition, and greatest slowing on measures of Attention and Emotion Recognition. However, there were no significant differences in psychotic-like experiences or cognitive performance as a function of PWS genetic subtype.
Conclusion

PWS is associated with a high prevalence of distressing psychotic-like experiences, which were associated with sleep disturbance. Findings indicate that self/parent-reported neurobehavioral symptoms and cognition can be assessed remotely in individuals with PWS, which has implications for future large-scale investigations of rare neurogenetic disorders.
Trial registration:
Not applicable.
The brain function state in different phase and relation with clinical symptoms in migraine: an fMRI study based on Reho
Authors: Lei Ming , Zhang Jun-Jian , Wu Dong-Mei 
Published: April 2021

Abstract
Objective

Through regional homogeneity (ReHo) to analyze the activation of brain regions at different phase in migraineurs and to explore its relationship with clinical symptoms.
Methods

we analyzed resting-state Resting brain functional magnetic resonance in 19 patients with episodes and 22 patients with interictal phase,22 healthy controls. Using regional homogeneity (ReHo) method to do post-processing. All subjects were evaluated by Montreal cognitive assessment scale (MoCA), simple mental state examination (MMSE), Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD). Subjects' clinical indicators (such as frequency of attack, course of disease, duration of each headache, and severity of headache) were correlated with ReHo values of brain regions. This study was approved by the ethics committee of Yangtze river shipping general hospital.
Results

the episodes group compared with the interictal group, Montreal Neurological Institute (MNI) (-9,42༌15)༌is that the ReHo value of bilateral anterior cingulate cortex was lower active than the interictal group; and Montreal Neurological Institute (MN) (-3༌-24༌66) ,the ReHo value of bilateral paracentrallobule was stronger active than the interictal group(P < 0.01). Compared with the control group, patients in interictal phase had lower activation in bilateral cuneus and bilateral lingual gyrus, MNI of the two are (9, -84, 36) and (0,-72,6). No significant different brain area was found between the episodes group and the control group. In episodes group, significant correlation was found between attack frequency and ReHo value of the bilateral paracentrallobule (r = 0.492; p = 0.038).
Conclusion

We need to observe the course of migraine as a whole. Even in the interictal, it may affect the development of the disease through the cuneus and lingual gyrus. ACC regulates different states of migraine by inducing anti-injury sensation regulation function. Paracentric lobule is not only associated with migraine attacks, but also with the frequency. it may have an effect with the outcome of subsequent migraines, whether become chronic, and the remodeling of the brain.
Good Operative Effects of Patellofemoral Arthroplasty Combined With the Tibial Tubercle Transfer for Isolated Patellofemoral Arthritis Patients With an Increased Tibial Tuberosity-trochlear Groove Distance
Authors: Dong Conglei , Zhao Chao , Li Ming , Kang Huijun , Piao Kang , Hao Kuo , Xu Chenyue , Wei Maozheng , Wang Fei 
Published: April 2021

Abstract
Purpose: The objective of present study was to investigate the operative effect of patellofemoral arthroplasty combined with the tibial tubercle transfer for isolated patellofemoral arthritis patients with an increased tibial tuberosity-trochlear groove distance (>20mm).Methods: A prospective study was performed between November 2012 and December 2017. Finally, thirty-six cases, with a mean age of 61.1 ± 7.3 years, were admitted to our study. A total of 17 patients underwent patellofemoral arthroplasty combined with tibial tubercle transfer, and 19 patients underwent patellofemoral arthroplasty only. All eligible patients had CT scans preoperatively and at 12 months follow-up, to assess the stability of the patellofemoral joint on axial slices. In addition, the demographic and clinical features of all the patients were asked. Knee balance was assessed with the single leg stance test and timed get up and go, and functionality was evaluated with stair climbing test and the Western Ontario and McMaster Universities Osteoarthritis Index score. (P>0.05)Results: Preoperatively, the data regarding the knee balance and functionality were not significantly different between the two Groups (P>0.05). Many measurements showed significant differences between the two groups at the last follow-up. Significant differences were seen in well-known measurements such as the SLST (Group I, 28.9 s (SD 7.5); Group II, 20.3 s (SD 5.9); p < 0.001), TGUG (Group I, 13.4 s (SD 3.2); Group II, 16.8 s (SD 3.1); p < 0.001), and SCT (Group I, 18.6 s (SD 6.8); Group II, 24.5 s (SD 8.7); p < 0.001). Additionally, the median WOMAC score was improved from 62.7 (SD 11.2) preoperatively to 25.7 (SD 8.2) one year postoperatively in Group I and from 64.1 (SD 10.7) to 36.2 (SD 9.7) in Group II, which were also significantly different between the groups.Conclusion: For such special IPA patients with an increased TT-TG (>20mm), the combined operation of PFA combined with TTT can better restore the involutional relationship of patellofemoral joint and further improve the balance and function of knee joint.
Metabotropic glutamate receptor subtype 2 is a receptor of SARS-CoV-2
Authors: Bu Zhigao , Wang Jinliang , Yang Guan , Wang Xinxin , Wen Zhiyuan , Shuai Lei , Luo Jie , Wang Chong , Sun Ziruo , Liu Renqiang , Ge Jinying , He Xijun , He Qianqian , Wang Xijun , Yang Xiao , Chen Weiye , Zhong Gongxun 
Published: April 2021

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative pathogen of novel coronavirus disease 2019 (COVID-19)1. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as a cellular receptor and enters cells via clathrin-mediated endocytosis (CME)2-4. However, the key molecules involved in internalizing and facilitating CME for virus entry remain unknown. Here, we found metabotropic glutamate receptor subtype 2 (mGluR2) is a key entry receptor for SARS-CoV-2 infection. mGluR2 directly interacts with the SARS-CoV-2 spike protein. Knockdown of mGluR2 decreases endocytosis of SARS-CoV-2 but not cell binding. mGluR2 cooperates with ACE2 to facilitate SARS-CoV-2 entry through CME. Knockout of the mGluR2 gene in mice abolished SARS-CoV-2 infection in the nasal turbinates and significantly reduced viral infection in the lungs. Importantly, mGluR2 also is important for severe acute respiratory syndrome coronavirus spike protein and Middle East respiratory syndrome coronavirus spike protein mediated endocytosis. Our study provides important insights into SARS-CoV-2 infection and reveals an important target for the development of novel approaches to limit coronavirus infection.
PROSE – Prospective Randomized Trial of the On-X Mechanical Prosthesis and the St Jude Medical Mechanical Prosthesis Evaluation (EDIT – March 21,2021&amp; April 16,2021)Part 1 – Preoperative Demographics and Preoperative and Operative Risk Factors
Authors: Jamieson William Robert Eric , Ely John L , Brink Johan , Pennel Timothy , Bannon Paul , Patel Jashvant , Gupta Rajiv Kumar , Rao Prasanna Simha Mohan , Agrawal Damyanti , Wiklund Lar , Kappetein A Pieter , Haaverstad Rune , Geisner Thomas , Doesnt Torsten , Schlensak Christian , Nair Sulgunan , Brown Craig , Siepe Matthias , Damiano Ralph J , Langlois Yves , Cherian KM , Azar Hormoz , Chen John C , Bavaria Joseph E , Fedoruk Lynn M , Munfakh Nabil A , Srid V , Scholz PM , Pfeffer TA , Ye Jian 
Published: April 2021

Abstract
ObjectivesThe PROSE trial purpose is to investigate whether the incidence of thromboembolic – related complications is reduced with a current generation mechanical prosthesis (On-X Life Technologies/CryoLife Inc. – On-X) compared with a previous generation mechanical prosthesis (St Jude Medical – SJM). The primary purpose of the initial report is to document the preoperative demographics, and the preoperative and operative risk factors by individual prosthesis and by Western and Developing populations. MethodsThe PROSE study was conducted in 29 worldwide centres and incorporated 854 subjects randomized between 2003 and 2016. The study enrollment was discontinued on August 31, 2016. The preoperative demographics incorporated age, gender, functional class, etiology, prosthetic degeneration, primary rhythm, primary valve lesion, weight, height, BSA and BMI. The preoperative and operative evaluation incorporated 24 risk factors.ResultsThe total patient population (854) incorporated On-X population (461) and the St Jude Medical population (393). There was no significant difference of any of the preoperative demographics between the On-X and SJM groups. The preoperative and operative risk factors evaluation showed there was no significant difference between the On-X and St Jude Medical populations. The preoperative and operative risk factors by valve position (aortic & mitral) also documented no differentiation. The dominant preoperative demographics of the Western world population were older age, male gender, sinus rhythm, aortic stenosis, congenital aortic lesion, and mitral regurgitation. The dominant demographics of the Developing world population were rheumatic etiology, atrial fibrillation, aortic regurgitation, mixed aortic lesions, mitral stenosis and mixed mitral lesions. The Developing world group had only one significant risk factor, congestive heart failure. The majority of the preoperative and operative risk factors were significant in the Western world population. ConclusionsThe preoperative demographics do not differentiate the prostheses but do differentiate the Western and Developing world populations. The preoperative and operative risk factors do not differentiate the prostheses BUT do differentiate the Western and Developing world populations.
Modified National Early Warning Score As Early Predictor of Outcome In COVID-19 Pandemic
Authors: Tagliabue Fabio , Schena Daniele , Galassi Luca , Magni Matteo , Guerrazzi Guglielmo , Acerbis Andrea , Rinallo Christina , Longhi Daniel , Ronzani Alberto , Mariani Pierpaolo 
Published: April 2021

Abstract
Aim: COVID-19 represented an important challenge to the Italian health care system (IHCS). Our main aim was to obtain evidence to support the use of modified national early warning score (m-NEWS) as an interdisciplinary, common and universal scoring scale to quickly recognize patients with a risk of clinical deterioration before admission and during hospitalization. As a secondary goal, we tried to find a score threshold that can be implemented in an optimal triaging protocol for an emergency setting where healthcare resources are overloaded as happened during COVID-19 pandemic. Methods: We performed a retrospective observational study. We included in our study all patients treated for COVID-19 infection in surgical departments between 01 March 2020 and 16 April 2020. Patients with negative test results for SARS-COV2 were excluded. m-NEWS score was obtained twice a day. Patients’ m-NEWS scores were analyzed in order to verify the correlation between m-NEWS (at admission and m-NEWS variation 24h after admission) and outcome (positive outcome-survival, negative outcome- death or intensive care unit (ICU) transfer). Results: We included a population based sample of 225 Sars Cov-2 infected patients. Overall, the average age at hospitalization was 71 (ranging from 40 to 95). 144 (64%) patients were males and 81 (36%) females. m-NEWS values lower or equal to 7 were associated to the majority of the "recovered" population (100/132 75,75%) and at the same time to the minority of the "non recovered" population (25/93 26,88%). Conclusions: For our sample, age is statistically correlated to the outcome but a triage protocol based solely on this variable is less effective than m-NEWS, which showed to be a reliable and easy-to-use score for first patient evaluation. Our observations pave the way towards further studies aiming at optimizing territorial and community healthcare management protocols.
Intranasal Curcumin Attenuates Silicosis by Inhibiting Matrix Metalloproteinase-9 (MMP-9) Activity in Mice
Authors: Kumari Sneha , Dash D , singh rashmi 
Published: April 2021

Abstract
Inhalation of crystalline silica causes silicosis, a type of occupational pulmonary fibrosis, is most prevalent among people working in industries related to construction.Curcumin being an antioxidant and anti-inflammatory in nature has shown anti-asthmatic effectsbut it has not yet been investigated to have any impact on silicosis. Therefore,our aim was to study impact of intranasal curcumin on lung fibrosis after sequentialsilica exposure. The mice model of silicosis was developed by intranasal silica instillation(2.5 mg/mice) for every alternate dayfor different durations, mainly 7, 14 and 21 days. This model of silicosis mimic chronic occupational exposure of silica dustand severe features of silicosis were developed in 21 days of silica exposure.One hour prior to silica administration, curcumin (5 mg/kg,i.n) and /or dexamethasone, a known corticosteroid (10 mg/kg,i.p)was administered in mice.Results haveshown that apart from being anti-inflammatory, curcumin is being reported here for the first time to possess anti-fibrotic effects where silica exposed airway inflammation and fibrosis was reduced after intranasal curcumin treatment. Reduced inflammatory cell recruitment, collagen deposition around the bronchioles and the alveolar spaces, hydroxyproline level and matrix metalloproteinases 9 (MMP 9) activity was noted in silicosis affected mice after curcumin administration.Remarkable reduction in oxidative stress markers like reactive oxygen species (ROS), nitric oxide, myeloperoxidases (MPO) and eosinophil peroxidase (EPO) levels wereobserved in curcumin treatment groupswhich was better and/or comparable to corticosteroid, dexamethasone.
Comparison of emission profile of black carbon and carbon monoxide over Eastern India: source apportionment and health risk impact
Authors: Ambade Balram , Sankar Tapan Kumar , Sahu Lokesh K. , Gautam Sneha , Gautam Alok Sagar 
Published: April 2021

Abstract
In the present study, black carbon (BC) mass concentration and carbon monoxide (CO) combination ratio were calculated simultaneously at two different cities (i.e.,Jamshedpur (JSR) and Kharagpur (KGP)) located in the eastern state of India. The analysis of GIOVANI NASA data indicates the highest concentrations of BC and CO in the Indo-Gangetic Plain (IGP) as well as the eastern part of India. The BC-CO relationship exhibited an excellent positive correlation (r2 = 0.65), while BC-PM2.5 showed a strong positive correlation (r2 > 0.96). On the other hand, the backward air trajectory showed pollutant transport mainly from India's northern part with some contributions from other countries likePakistan, Nepal, Bhutan etc. BC concentration overall health risk assessment was demonstrated as 6.27, 12.43, 11.22 and 25.60 in JSR and 2.02, 4.02, 3.63 and 8.28 in KGP, passive cigarettes comparable concerning the risk of lung cancer, low birth weight, cardiovascular mortality, and percentage lung function decrement of school-aged children.
Schwannoma of the Posterior Pharyngeal Wall in a Child
Authors: zhu peng , li xiao yan 
Published: April 2021

Abstract
Background: To our knowledge, There are only 7 cases of posterior pharyngeal wall schwannoma which have been previously reported in the literature, but none of them was associated with a 3-year-old child.Case presentation: We presented a rare case of a schwannoma which is localized on the posterior pharyngeal wall, It caused severe difficulty in swallowing and breathing in a child whose age is three years old. Schwannomas of the posterior pharyngeal wall has been rarely reported in children, The tumor was removed with plasma radio frequency excision via a transoral route, There was not seen any recurrence of tumor by examination of CT or MRI up to two years. as far as we know, It's the first time which a case of posterior pharyngeal wall schwannoma that has been reported to occur in a 3-year-old child, and the first case in which the schwannoma was removed via transoral plasma radio frequency excision.Conclusions: This case illustrates that schwannoma may be found in children ,and it is safe to treat this disease through plasma radio frequency excision via a transoral route.