bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Implementation of Internet of Everything’s Business Platform Ecosystem
Authors: Mishra Shrutika , Tripathi A. R. , Singh R.S. , Mishra Priyanshu 
Published: April 2021

Abstract
Internet of Everything plays a vital role for the business and industry. Internet of everything’s is an assembly of technologies, strategies over the network strategies and connections which required a set of protocols, data server storage strategy, infrastructure mechanism, integration of all technology, and communication protocols with all the connecting devices. Internet of everything’s (IoE) is a diversified and distributed interconnection of the platform strategies, heterogeneous devices through man and machines over the Internet. Business tycoons are continuously shifting their business model to innovative business model with internet technology-based features. The IoE based model able to generate and capture huge amounts of data in nano seconds. Industrialist using this data driven approach in their businesses to generate huge number of profits from their business. IoE based data driven approach learn from existing patterns and solutions to predict the future behavior and analytics of business. There is however, very little attention has given on platform business models from an Internet of Everything viewpoint and data driven approaches. In this study we examine up-to-date landscape of IoE business platform ecosystem along with 5G and 6G technology scope for business to how they can be integrated to work on IoE platform ecosystem. JEL Classification: M10, M12, M13, M15, M16, M21, M31, M37.
The efficacy of first-line ART regimens based on RPV in HIV-infected patients with pre-existing E138A mutation in reverse transcriptase
Authors: Kuznetsova Anna , Lebedev Aleksey , Gromov Konstantin , Kazennova Elena , Zazzi Maurizio , Incardona Francesca , Sönnerborg Anders , Bobkova Marina 
Published: April 2021

Abstract
Introduction It was previously shown that the presence of the E138A mutation is associated with resistance to rilpivirine (RPV). Detection of this mutation is considered as contraindication for RPV use within the first-line ART. It is a lack of knowledge regarding efficacy of first-line RPV-based ART in patients bearing HIV with E138A mutation. In absence of HIV genotyping in naïve patients it may influence the clinical decisions.Methods We have collected all available patients unconventionally treated with RPV and carefully analyzed the ART efficacy in E138A carriers from the EuResist database. The viral load data in patients with E138A mutation at baseline was extracted from the database. Due to uniqueness of these cases only 11 HIV infected patients were found. The virologic outcome was analyzed according to the national and international ART guidelines.Results The full virologic efficacy of the first-line RPV-based ART regimen was demonstrated in 11 out of 11 patients according to all guidelines.Conclusions Our data suggest that the influence of the pre-existing E138A mutation on the sensitivity to RPV is very low or insignificant. The results support importance of investigation of polymorphic pre-existing HIV drug mutations for ART efficacy.
Exercise-induced Thoracic Outlet Syndrome and Concomitant Osteomyelitis in Cervical Rib with a Possible Familial Origin, a Case Report.
Authors: Gul Mohammadshah Isam , Bilal Ammara Bint I , Ata Fateen , Ibrahem Renan E , Danjuma Muhammad I 
Published: April 2021

Abstract
BackgroundCervical ribs are a rare and usually asymptomatic occurrence. Most are identified incidentally by Roentgenogram (X-rays). However, occasionally they can cause nerve impingements and compressive symptoms. In cervical ribs, osteomyelitis secondary to trauma is unheard of. We report such a case made more interesting by the familial presence of bilateral cervical ribs in 2 generations. This indicates a possible familial origin. Case presentationA 26-year-old woman known to have fibromyalgia presented with left shoulder pain and fever episodes. She was recently discharged from intensive physiotherapy for fibromyalgia management, but the pain aggravated instead of getting better unilaterally in the left arm after discharge. Electric shock-like sensations and reduced strength accompanied this. An evaluation revealed leukocytosis and S. aureus positive blood and urine cultures along with bilateral complete cervical ribs showing pseudoarthrosis of anterior left cervical rib. A collection was noted in the left scalene muscle near the pseudoarthrosis accompanying focal edema suggesting osteomyelitis. Transthoracic echocardiogram (TTE) ruled out infective endocarditis. Thoracic surgery recommended conservative management, and appropriate antibiotics were given, which resulted in the negative culture on day 6. The patient was discharged on appropriate analgesia, and her pain was significantly improved on discharge.ConclusionsThis is the first reported case of osteomyelitis in the cervical rib. This report also highlights the possibility of cervical ribs having a familial origin. Additionally, as in our patient, certain exercises can be a risk factor for inducing TOS in patients with cervical rib.
Recurrence of pemphigus vulgaris after bilateral breast irradiation: a case report and review of the literature
Authors: Invernizzi Camille , Gaultier Victor , Guilbert Philippe , Jouannaud Christelle , Labrousse Anne Laure , CRETY Charles MARCHAND 
Published: April 2021

Abstract
Background
Pemphigus is a serious and rare chronic bullous autoimmune disease. It is characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 and 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus is based on the triggering of genetic and external environmental factors such as drugs, infection and more rarely radiotherapy. To date, only 16 cases of radiation-induced pemphigus are described in a context of breast cancer treatment.
Case presentation:
We present the case of a 76-year-old woman who had a recurrence of pemphigus vulgaris limited to the irradiation field after exposure to an adjuvant radiotherapy treatment for a bilateral triple negative breast cancer. The onset was bilateral limited to the irradiation area and was treated effectively with local and systemic corticosteroids. After a rigorous review of the literature, only 16 cases of breast cancer radiation-induced pemphigus appeared. In contrast to several cases, the rash was limited to the irradiated area and improved with systemic corticosteroids.
Conclusions
Pemphigus is a very rare side effect of radiotherapy, notably in breast cancer. For more than three-quarters of the described cases in the literature, this condition occurs within three months following the end of treatment. After systemic immunosuppressive treatment, this disease disappears in the vast majority of the reported cases.
Production of spiculisporic acid by Talaromyces trachyspermus in fed-batch bioreactor culture
Authors: Moriwaki-Takano Maki , Asada Chikako , Nakamura Yoshitosi 
Published: April 2021

Abstract
Spiculisporic acid (SA) is a fatty acid-type biosurfactant with one lactone ring and two carboxyl groups. It has been used in metal removers and cosmetics, because of its low propensity to cause irritation to the skin, its antibacterial properties, and high surface activity. In the present study, we report an effective method for producing SA by selecting a high-producing strain and investigating the effective medium components, conditions, and environments for its culture. Among the 11 kinds of Talaromyces species, T. trachyspermus NBRC 32238 showed the highest production of a crystalline substance, which was determined to be SA using NMR. The strain was able to produce SA under acidic conditions from hexoses, pentoses, and disaccharides, with glucose and sucrose serving as the most appropriate substrates. Investigation of nitrogen sources and trace metal ions revealed meat extract and FeCl3 as components that promoted SA production. Upon comparing the two types of cultures with glucose in a baffle flask or aeration bioreactor, SA production was found to be slightly higher in the flask than in the reactor. In the bioreactor culture, sucrose was found to be an appropriate substrate for SA production, as compared to glucose, because with sucrose, the lag time until the start of SA production was shortened. Finally, fed-batch culture with sucrose resulted in 60 g/L of SA, with a total yield of 0.22 g SA/g sucrose and a productivity of 6.6 g/L/d.
Pathogenic variants identified by whole-exome sequencing in Chinese patients with primary ciliary dyskinesia
Authors: Yutian Ye , Qijun Huang , Lipeng Chen , Chunxian Liang , Fang Yuan , Shenggguo Liu , Lu Liu , Xiangxia Zhang , Jie Li , Hua Dang , Rongchang Chen , Yingyun Fu , Yue Yongjian 
Published: April 2021

Abstract
Background: The genetic factors contributing to primary ciliary dyskinesia (PCD), a rare autosomal recessive disorder, remain elusive for approximately 20–35% of patients with complex and abnormal clinical phenotypes. Our study aimed to identify causative variants of PCD-associated pathogenic candidate genes using whole-exome sequencing (WES). Methods: All patients were diagnosed with PCD based on clinical phenotype or transmission electron microscopy (TEM) images of cilia. WES and bioinformatic analysis were then conducted for patients with PCD. Identified candidate variants were validated by Sanger sequencing. Pathogenicity of candidate variants was then evaluated using in silico software and the American College of Medical Genetics and Genomics (ACMG) database.Results: In total, 15 rare variants were identified in patients with PCD, among which were three homozygous causative variants (including one splicing variant) in the PCD-associated genes CCDC40 and DNAI1. Moreover, two stop-gain heterozygous variants of DNAAF3 and DNAH1 were classified as pathogenic variants by the ACMG criteria.Conclusions: This study identified novel potential pathogenic genetic factors associated with PCD. Noteworthy, the PCD patients carried multiple rare causative gene variants, thereby suggesting that known causative genes along with other functional genes should be considered for such heterogeneous genetic disorders.
Human Rights Violations and Associated Factors of the Hijras in Bangladesh- A Cross sectional study
Authors: Amanullah ASM , Abir Tanvir , Husain Taha , Lim David , Osuagwu Uchechukwu Levi , Ahmed Giasuddin , Ahmed Saleh , Yazdani Dewan Muhammad Nur -A , Agho Kingsley E 
Published: April 2021

Abstract
Background

Hijras in Bangladesh face considerable discrimination, stigma, and violence despite the 2013 legislation to preserve the rights of their right. There is a dearth of published literature describing the extent of human right violations among this population and their associated factors.
Methods

A questionnaire was administered to 346 study participants aged 15 years and older, living in five urban cities of Bangladesh who self-identified as Hijra, in 2019. The six human rights violation indicators (Economic, Employment, Health, Education, Social and Civil and Political Right) assessed were categorized as binary. Associations between sociodemographic characteristics and the six human right violations were tested using univariate and multivariate logistic regression.
Results

Human right violations including economic, educational, political, employment, health and social/civil right violations were observed in 73.3%, 59.3%, 58.5%, 46.4%, 42.7%, 34.4% of the participants, respectively. Economic rights violations was associated with bisexuality (Adjusted odds ratios AOR 3.60, 95%CI: 1.57, 8.26) and not living with family (AOR 2.71, 95%CI: 1.21, 6.09), while Hijras who earned more than 10,000 Bangladesh Taka experienced higher odds of educational (AOR 2.77, 95%CI: 1.06, 7.19) and political rights violations (AOR 4.30, 95%CI: 1.06, 7.44). Living in Dhaka city decreased the odds of economic and political right violation while experiencing violations of one human right could lead to violation of another in the Hijra community.
Conclusion

Human rights violations were common in Bangladesh Hijras, particularly the Bisexual Hijras. Media and educational awareness campaigns are needed to address the underlying roots of a violation. Programs focused on the families, young people and high-income earners of this community are needed in Bangladesh.
Predictors of poor outcome from aneurysmal subarachnoid hemorrhage and an exploratory analysis into the causes of delayed neurosurgical clipping at a major public hospital in the Philippines
Authors: Ferraris Kevin Paul , Golidtum Jared Paul , Palabyab Eric Paolo M. , Salloman Alain James , Alcazaren Jose Carlos , Seng Kenny , Navarro Joseph Erroll , Reyes Kenneth de los 
Published: April 2021

Abstract
Objective:The provision of neurosurgical care for patients with aneurysmal subarachnoid hemorrhage (SAH) is beset with particular challenges in low- to middle-income countries (LMICs) like the Philippines. In this study located in a low-resource setting, we identify the factors that contribute to unfavorable outcomes of dependency and death. Methods:The authors retrospectively reviewed 106 patients who underwent surgery for aneurysmal subarachnoid hemorrhage in a single institution from January 2016 to September 2018. Data were obtained on exposure variables comprising patient demographics, clinical features, perioperative management, and complications and other interventions; while outcomes on discharge were investigated using the modified Rankin scale (mRS). Descriptive statistics and multivariate logistic regression analyses were done. Root cause analysis was done to identify the causes of delay.Results:The percentage of patients who had unfavorable outcome (mRS ≥ 3) was 29.2%. The timing of surgery—whether early (<3 days), intermediate (3-10 days), or late (>10 days)—was not found to be significantly associated with dependency or mortality. On multiple logistic regression, the factors associated with unfavorable outcome were: intraoperative rupture (OR 23.98, 95%CI 3.56–161.33, p=0.001), vasospasm (OR 12.47, 95%CI 3.01–51.57, p<0.001), and a high Hunt & Hess grade (OR 5.96, 95%CI 1.47–24.18, p=0.012). Intraoperative rupture and vasospasm were further found to be independent predictors of mortality. Many causes of delay were identified in terms of patient-, provider-, and health system-levels. These constitute as barriers to timely care and also contribute to the gap in quality and efficiency of neurosurgical treatment situated in low-resource settings in LMICs.Conclusion:The identified predictors of poor outcomes, as well as the causes delays in neurosurgical treatment, pose as significant challenges to the care of socioeconomically-disadvantaged SAH patients. When considering the solutions to these challenges, the broader environment of practice ought to be taken into account.
Assessment of factors affecting willingness to blood donations among Hawassa town Population Southern, Ethiopia,2020.
Authors: Girma Belete , Deneke Hiwot , Mohammed Yusuf 
Published: April 2021

Abstract
Background: Blood donation remain a unique act to save the lives of people who encounter critical surgical and medical conditions. Since the request for blood supply is extremely high, a shortage of blood causes significant morbidity and mortality. To increase blood supply and maintain an adequate quantity of blood, regular and volunteer blood donation practice is needed. Ethiopia is one of the lowest annual donation rates which is 0.8/1000 population. This study assesses factors affecting willingness to donate blood among Hawassa Town's southern Population.Objectives: To assess the factors affecting willingness to blood donation among Hawassa town population Southern, Ethiopia. Methods: A community-based cross-sectional investigation was conducted in Hawassa Town in November 2020. A multi-stage sampling procedure was utilized to select the study population. At Stage one, three Kebeles are taken from a total of 32 Kebele, at stage two implementing a systematically sampling method used to draw the total sample size, proportional to the population of each kebele and each study unit are selected randomly from Each household. Data were collected using a structured interviewer questionnaire. Data entered and analyzed using SPSS version 20. Result: A total of 633 participants was included in the final analysis (response rate = 100%). Among which 212(33.5%) were female and 421 (66.5%) were Male. The average age was 30.95 ±2.0 years.Among the study participants, 490(77.4) are willing to donate blood in the future, and 125(22.9%) of them had blood donation practices in the past. The most prominent factors that affect the willingness of the participants for blood donation were, Unfit to donate, fear of needle prick and Not approached to donated (45.2%, 38.5%, and 11.7%) respectively. Most of the respondents 382 (60.3%) reported that voluntary donor is the best source of protected blood. Desire to aid other and age of study Participant age greater 25 years are significantly associated factor for increased willingness to blood donated (AOR 2.146 (0.028, 0.753) and (AOR = 1.8 (95% CI 1.1, 3.0) respectively.Conclusion: Only minor proportion of the participants donated blood in the past, but Majority of the participant was willing to donate blood in the future. The crucial factors that participants are not willing to donate blood are Unfit to donate, fear of needle prick, and Not approached to donate. There is a need to improve awareness on who and when a person capable to donate blood and organizing campaigns to increase awareness on the importance of blood donation for those who are willing to donate blood in the future, to produce a pool of eligible blood donors.
"DETEFISIO”: a inserção de um jogo educativo como ferramenta de aprendizagem remota para alunos do curso de Fisioterapia
Authors: Kenia Alves Fabíola , Fernandes Silva Bruno , Cesar Ivana Daniela , Danailof Kátia 
Published: April 2021

O processo educativo tem passado por várias modificações, especialmente após o isolamento social imposto pela pandemia do Coronavírus e substituição de aulas presenciais por remotas. A adequação de recursos educativos aos interesses dos alunos é necessária neste contexto. O objetivo deste trabalho é relatar a experiência da inserção do jogo “DETEFISIO” em uma disciplina do curso de Fisioterapia de maneira remota. Metodologia. Trata-se de um relato da experiência a partir da observação e percepção da docente sobre a implementação do jogo educativo adaptado para o formato on-line a partir da ferramenta Zoom e aplicado a 24 alunos do período matutino e 21 alunos do período noturno do décimo semestre do curso de Fisioterapia. Foi utilizado o tempo de aula de 1 hora e 40 minutos. O objetivo principal do jogo era, a partir das dicas, descobrir a patologia reumatológica correspondente aos sintomas e achados clínicos e complementares e descrever o tratamento fisioterapêutico indicado. Resultados. O jogo foi capaz de trabalhar a relação entre diagnóstico e tratamento fisioterapêutico promovendo uma participação ativa dos alunos mesmo de maneira remota. Conclusão. Trabalhar com jogos educacionais pode ser uma opção promissora para a otimização do processo da aprendizagem, pois estes colaboram de maneira lúdica na compreensão do conteúdo e favorecem o trabalho em grupo.
Jubileusz 90-lecia Akademii Wychowania Fizycznego Józefa Piłsudskiego w Warszawie
Authors: Pawlikowska-Piechotka Anna 
Published: April 2021

Rok 2019 jest rokiem szczególnym, z uwagi na 90. rocznicę powołania uczelni. W latach 1929–2019 mury warszawskiej Akademii Wychowania Fizycznego Józefa Piłsudskiego opuściło ponad 50 000 absolwentów, wypromowano licznych doktorów i doktorów habilitowanych, zbudowano poważny potencjał naukowo-badawczy. Obecnie studiuje na pięciu wydziałach i dziewięciu kierunkach 4557 studentów. Absolwenci mają wysokie kwalifikacje, odpowiadające potrzebom społeczeństwa XXI w.: są zatrudniani jako nauczyciele, trenerzy, instruktorzy, fizjoterapeuci, pielęgniarze, kosmetolodzy i specjaliści terapii zajęciowej – są wysoko cenionymi specjalistami zatrudnianymi w Polsce i w innych krajach w Europie. Z okazji Jubileuszu organizowane są konferencje naukowe, sympozja, publikacje, wystawy, imprezy sportowe i kulturalne – podkreślające chlubną tradycję i podsumowujące znaczący dorobek uczelni.
Predictability of COVID-19 Hospitalizations, Intensive Care Unit Admissions, and Respiratory Assistance in Portugal: Longitudinal Cohort Study
Authors: Patrício André , Costa Rafael S , Henriques Rui 
Published: April 2021

Background
In the face of the current COVID-19 pandemic, the timely prediction of upcoming medical needs for infected individuals enables better and quicker care provision when necessary and management decisions within health care systems.

Objective
This work aims to predict the medical needs (hospitalizations, intensive care unit admissions, and respiratory assistance) and survivability of individuals testing positive for SARS-CoV-2 infection in Portugal.

Methods
A retrospective cohort of 38,545 infected individuals during 2020 was used. Predictions of medical needs were performed using state-of-the-art machine learning approaches at various stages of a patient’s cycle, namely, at testing (prehospitalization), at posthospitalization, and during postintensive care. A thorough optimization of state-of-the-art predictors was undertaken to assess the ability to anticipate medical needs and infection outcomes using demographic and comorbidity variables, as well as dates associated with symptom onset, testing, and hospitalization.

Results
For the target cohort, 75% of hospitalization needs could be identified at the time of testing for SARS-CoV-2 infection. Over 60% of respiratory needs could be identified at the time of hospitalization. Both predictions had >50% precision.

Conclusions
The conducted study pinpoints the relevance of the proposed predictive models as good candidates to support medical decisions in the Portuguese population, including both monitoring and in-hospital care decisions. A clinical decision support system is further provided to this end.