bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer incidence estimation from mortality data: a validation study within a population-based cancer registry
Authors: Redondo-Sánchez Daniel , Rodríguez-Barranco Miguel , Ameijide Alberto , Alonso Francisco Javier , Fernández-Navarro Pablo , Jiménez-Moleón Jose Juan , Sánchez María-José 
Published: March 2021

Abstract
Background
Population-based cancer registries are required to calculate cancer incidence in a geographical area, and several methods have been developed to obtain estimations of cancer incidence in areas not covered by a cancer registry. However, an extended analysis of those methods in order to confirm their validity is still needed.

Methods
We assessed the validity of one of the most frequently used methods to estimate cancer incidence, on the basis of cancer mortality data and the incidence-to-mortality ratio (IMR), the IMR method. Using the previous 15-year cancer mortality time series, we derived the expected yearly number of cancer cases in the period 2004–2013 for six cancer sites for each sex. Generalized linear mixed models, including a polynomial function for the year of death and smoothing splines for age, were adjusted. Models were fitted under a Bayesian framework based on Markov chain Monte Carlo methods. The IMR method was applied to five scenarios reflecting different assumptions regarding the behavior of the IMR. We compared incident cases estimated with the IMR method to observed cases diagnosed in 2004–2013 in Granada. A goodness-of-fit (GOF) indicator was formulated to determine the best estimation scenario.

Results
A total of 39,848 cancer incidence cases and 43,884 deaths due to cancer were included. The relative differences between the observed and predicted numbers of cancer cases were less than 10% for most cancer sites. The constant assumption for the IMR trend provided the best GOF for colon, rectal, lung, bladder, and stomach cancers in men and colon, rectum, breast, and corpus uteri in women. The linear assumption was better for lung and ovarian cancers in women and prostate cancer in men. In the best scenario, the mean absolute percentage error was 6% in men and 4% in women for overall cancer. Female breast cancer and prostate cancer obtained the worst GOF results in all scenarios.

Conclusion
A comparison with a historical time series of real data in a population-based cancer registry indicated that the IMR method is a valid tool for the estimation of cancer incidence. The goodness-of-fit indicator proposed can help select the best assumption for the IMR based on a statistical argument.
Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage
Authors: Li Ting , Zhao Jin , Xie Wenguang , Yuan Wanru , Guo Jing , Pang Shengru , Gan Wen-Biao , Gómez-Nicola Diego , Zhang Shengxiang 
Published: March 2021

Abstract
Background
Ischemia can induce rapid activation of microglia in the brain. As key immunocompetent cells, reactive microglia play an important role in pathological development of ischemic stroke. However, the role of activated microglia during the development of ischemia remains controversial. Thus, we aimed to investigate the function of reactive microglia in the early stage of ischemic stroke.

Methods
A Rose Bengal photothrombosis model was applied to induce targeted ischemic stroke in mice. CX3CR1CreER:R26iDTR mice were used to specifically deplete resident microglia through intragastric administration of tamoxifen (Ta) and intraperitoneal injection of diphtheria toxin (DT). At day 3 after ischemic stroke, behavioral tests were performed. After that, mouse brains were collected for further histological analysis and detection of mRNA expression of inflammatory factors.

Results
The results showed that specific depletion of microglia resulted in a significant decrease in ischemic infarct volume and improved performance in motor ability 3 days after stroke. Microglial depletion caused a remarkable reduction in the densities of degenerating neurons and inducible nitric oxide synthase positive (iNOS+) cells. Importantly, depleting microglia induced a significant increase in the mRNA expression level of anti-inflammatory factors TGF-β1, Arg1, IL-10, IL-4, and Ym1 as well as a significant decline of pro-inflammatory factors TNF-α, iNOS, and IL-1β 3 days after stroke.

Conclusions
These results suggest that activated microglia is an important modulator of the brain’s inflammatory response in stroke, contributing to neurological deficit and infarct expansion. Modulation of the inflammatory response through the elimination of microglia at a precise time point may be a promising therapeutic approach for the treatment of cerebral ischemia.
Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
Authors: Qie Peng , Yin Qifan , Xun Xuejiao , Song Yongbin , Zhou Shaohui , Liu Huining , Feng Junpeng , Tian Ziqiang 
Published: March 2021

Abstract
Background
Esophageal squamous cell carcinoma(ESCC) is one of the most common tumors worldwide. Esophagectomy with three-field lymph node dissection(3FLND) is the radical surgical procedure for esophageal cancer. However, 3FLND is not widely used due to it’s higher mortality rate and higher incidence of postoperative complications. There is an urgent need to identify novel biomarkers that can guide the most proper lymph-node dissection in esophageal cancer patients.

Method
Ninety-two patients with thoracic ESCC undergoing 3FLND were enrolled into our study from the Department of Thoracic Surgery of the Fourth Hospital affiliated to the Hebei Medical University and Hebei General Hospital between Jun 2011 and Dec 2015. Retrospectively collected data from these 92 patients was used to explore the relationship between the lymph-node metastasis、recurrence and the SPRY4-IT1 expression level and to determine whether 3FLND should be performed in patients with thoracic ESCC.

Results
The findings revealed that the SPRY4-IT1 expression was significantly higher in esophageal cancer tissues than in adjacent noncancerous tissues. (P < 0.01). Furthermore, the high expression of SPRY4-IT1 was significantly correlated with tumor differentiation (P = 0.029), T classification (P = 0.013), lymph node metastasis(P = 0.022) and pathological stage (P = 0.001). The increased expression of SPRY4-IT1 was associated with a higher risk of cervical and superior mediastinal lymph-node metastasis(P = 0.039).However, no significant association was observed between the risk of cervical and superior mediastinal lymph-node recurrence and the SPRY4-IT1 expression level in the thoracic ESCC patients performed 3FLND(P = 0.509).

Conclusions
Our data support the assumption that the high expression of SPRY4-IT1 is associated with a high risk of lymph node metastasis and it has potential application as a indicator for guiding on three-field lymph node dissection in patients with thoracic ESCC. Randomized controlled trials with a large cohort of patients will be needed to confirm this conclusion in the future.
Shaping duo binary turbo-coded BICM scheme for JPWL image transmission using a link adaptation strategy over wireless channels
Authors: Hadji Ahmed , Bouazza Boubakar S. , Boeglen Hervé , Perrine Clency , Nouri Keltouma , Chatellier Christian , Pousset Yannis 
Published: March 2021

AbstractIn order to guarantee a robust transmission of JPWL (JPEG Wireless: Joint Photographic Experts Group Wireless) images through time and frequency selective wireless channels, an efficient adaptive communication strategy is proposed. It is based on an optimization of a closed-loop adaptive multiple-input multiple-output, orthogonal frequency division multiplexing (MIMO-OFDM) scheme associated with a shaping BICM (bit-interleaved coded modulation) technique composed of a duo binary turbo code (DBTC), high-order modulations such as 64–256 QAM (Quadrature Amplitude Modulation) and a shaping code. According to the CSI (channel state information) knowledge at the transmitter side, an algorithm based on unequal error protection (UEP) and unequal power allocation (UPA) is used to select the transmitter key parameters (source/channel encoder rate, modulation order, power, number of quality layers and number of iterations of the Turbo decoder) to achieve the target Quality of Service (QoS). The proposed DBTC-shaping BICM scheme reaches a shaping gain of 1.2 dB for a 256 QAM modulation over a SISO Gaussian channel, whereas only 0.7 dB of shaping gain can be achieved in a scheme that uses the LDPC shaping BICM scheme for the same modulation order. Based on a DBTC shaping BICM scheme and an adaptive algorithm, the proposed MIMO-OFDM strategy achieves better performance compared to a strategy using an iterative process between an RS (Reed-Solomon) and arithmetic decoders. As a result, and on the one hand, a gain of 5.38 dB can be achieved in terms of PSNR (peak signal-to-noise ratio). On the other hand, a gain of 78% in terms of power consumption is obtained for the same QoS level. Moreover, the adaptive number of iterations in the proposed strategy can minimize the computational complexity of the turbo decoding compared to a scheme using four iterations whatever the channel conditions.
Spatiotemporal dynamics for a diffusive mussel–algae model near a Hopf bifurcation point
Authors: Zhong Shihong , Cheng Xuehan , Liu Biao 
Published: March 2021

AbstractIn this paper, the Hopf bifurcation and Turing instability for a mussel–algae model are investigated. Through analysis of the corresponding kinetic system, the existence and stability conditions of the equilibrium and the type of Hopf bifurcation are studied. Via the center manifold and Hopf bifurcation theorem, sufficient conditions for Turing instability in equilibrium and limit cycles are obtained, respectively. In addition, we find that the strip patterns are mainly induced by Turing instability in equilibrium and spot patterns are mainly induced by Turing instability in limit cycles by numerical simulations. These provide a comprehension on the complex pattern formation of a mussel–algae system.
A predator–prey model involving variable-order fractional differential equations with Mittag-Leffler kernel
Authors: Khan Aziz , Alshehri Hashim M. , Gómez-Aguilar J. F. , Khan Zareen A. , Fernández-Anaya G. 
Published: March 2021

AbstractThis paper is about to formulate a design of predator–prey model with constant and time fractional variable order. The predator and prey act as agents in an ecosystem in this simulation. We focus on a time fractional order Atangana–Baleanu operator in the sense of Liouville–Caputo. Due to the nonlocality of the method, the predator–prey model is generated by using another FO derivative developed as a kernel based on the generalized Mittag-Leffler function. Two fractional-order systems are assumed, with and without delay. For the numerical solution of the models, we not only employ the Adams–Bashforth–Moulton method but also explore the existence and uniqueness of these schemes. We use the fixed point theorem which is useful in describing the existence of a new approach with a particular set of solutions. For the illustration, several numerical examples are added to the paper to show the effectiveness of the numerical method.
Early oral protein-containing diets following elective lower gastrointestinal tract surgery in adults: a meta-analysis of randomized clinical trials
Authors: Pu Hong , Heighes Philippa T. , Simpson Fiona , Wang Yaoli , Liang Zeping , Wischmeyer Paul , Hugh Thomas J. , Doig Gordon S. 
Published: March 2021

AbstractBackgroundAlthough current guidelines make consensus recommendations for the early resumption of oral intake after surgery, a recent comprehensive meta-analysis failed to identify any patient-centered benefits. We hypothesized this finding was attributable to pooling studies providing effective protein-containing diets with ineffective non-protein liquid diets. Therefore, the aim of this paper was to investigate the safety and efficacy ofearly oral protein-containing dietsversus later (traditional) feeding after elective lower gastrointestinal tract surgery in adults.MethodsPubMed, Embase, and the China National Knowledge Infrastructure databases were searched from inception until 1 August 2019. Reference lists of retrieved studies were hand searched to identify randomized clinical trials reporting mortality. No language restrictions were applied. Study selection, risk of bias appraisal and data abstraction were undertaken independently by two authors. Disagreements were settled by obtaining an opinion of a third author. Majority decisions prevailed. After assessment of underlying assumptions, a fixed-effects method was used for analysis. The primary outcome was mortality. Secondary outcomes included surgical site infections, postoperative nausea and vomiting, serious postoperative complications and other key measures of safety and efficacy.ResultsEight randomized clinical trials recruiting 657 patients were included. Compared with later (traditional) feeding, commencing an early oral protein-containing diet resulted in a statistically significant reduction in mortality (odds ratio [OR] 0.31,P= 0.02,I2= 0%). An early oral protein-containing diet also significantly reduced surgical site infections (OR 0.39,P= 0.002,I2= 32%), postoperative nausea and vomiting (OR 0.62,P= 0.04,I2= 37%), serious postoperative complications (OR 0.60,P= 0.01,I2= 25%), and significantly improved other major outcomes. No harms attributable to an early oral protein-containing diet were identified.ConclusionsThe results of this systematic review can be used to upgrade current guideline statements to agrade A recommendationsupporting anoral protein-containing dietcommenced before the end of postoperative day 1 after elective lower gastrointestinal surgery in adults.
Comparison of the performances of low-crystalline carbonate apatite and Bio-Oss in sinus augmentation using three-dimensional image analysis
Authors: Nagata Koudai , Fuchigami Kei , Kitami Ryoji , Okuhama Yurie , Wakamori Kana , Sumitomo Hirokazu , Kim Hyunjin , Okubo Manabu , Kawana Hiromasa 
Published: March 2021

AbstractBackgroundIn locations where the alveolar bone height is low, such as at the maxillary molars, implant placement can be difficult, or even impossible, without procedures aimed at generating new bone, such as sinus lifts. Various types of bone graft materials are used after a sinus lift. In our study, a three-dimensional image analysis using a volume analyzer was performed to measure and compare the volume of demineralized bovine bone mineral (Bio-Oss®) and carbonate apatite (Cytrans®) after a sinus lift, as well as the amount of bone graft material resorption. Patient data were collected from cone-beam computed tomography images taken before, immediately following, and 6 months after the sinus lift. Using these images, both the volume and amount of resorption of each bone graft material were measured using a three-dimensional image analysis system.ResultsThe amount of bone resorption in the Bio-Oss®-treated group was 25.2%, whereas that of the Cytrans®-treated group was 14.2%. A significant difference was found between the two groups (P< 0.001).ConclusionsOur findings indicate that the volume of bone resorption was smaller in the Cytrans®-treated group than in the Bio-Oss®-treated group, suggesting that Cytrans® is more promising for successful implant treatments requiring a sinus lift.
A case of vascular Ehlers–Danlos syndrome with a ruptured hepatic artery after surgical treatment of peritonitis caused by the perforation of the colon
Authors: Kakinuma Daisuke , Yamada Takeshi , Kanazawa Yoshikazu , Matsuno Kunihiko , Sahara Tomoko , Yoshida Hiroshi 
Published: March 2021

Abstract
Background
Ehlers–Danlos syndrome (EDS) is an inherited disorder that causes connective tissue fragility. The vascular type of EDS (vEDS) caused by defective collagen type III production accounts for 5%–10% of all EDS cases. Patients can develop gastrointestinal or arterial ruptures, which cause poor prognosis. We report a case of a patient who experienced colonic rupture, which was immediately followed by arterial rupture.

Case presentation
A 40-year-old man who had been genetically diagnosed with vEDS 6 years previously was admitted to our hospital with ischemic colitis. After 3 days of conservative treatment, his abdominal pain worsened, and computed tomography (CT) revealed free air in the abdominal cavity. Pan-peritonitis due to perforation of the sigmoid colon was diagnosed. Intraperitoneal lavage and drainage and Hartmann’s operation were urgently performed. Because the patient had confirmed vEDS, we performed the surgery in a protective manner. The postoperative course was initially good, and he was transferred to the general ward 3 days after surgery. However, 5 days after surgery, massive intra-abdominal hemorrhage suddenly occurred, and contrast-enhanced CT showed an aneurysm in the common hepatic artery that had ruptured; this aneurysm was not present before surgery and was far from the surgical field. Although we considered an emergency operation, the patient suddenly experienced cardiac arrest and was unresponsive to resuscitation.

Conclusions
In cases of vEDS, vascular rupture can occur immediately after surgery for intestinal rupture. We recommend paying special attention to vascular complications in patients in their forties, as such complications are the most common causes of death.
Quantitative comparison of data-driven gating and external hardware gating for 18F-FDG PET-MRI in patients with esophageal tumors
Authors: Kvernby Sofia , Hult Nafsika Korsavidou , Lindström Elin , Sigfridsson Jonathan , Linder Gustav , Hedberg Jakob , Ahlström Håkan , Bjerner Tomas , Lubberink Mark 
Published: March 2021

Abstract
Background
Respiratory motion during PET imaging reduces image quality. Data-driven gating (DDG) based on principal component analysis (PCA) can be used to identify respiratory signals. The use of DDG, without need for external devices, would greatly increase the feasibility of using respiratory gating in a routine clinical setting. The objective of this study was to evaluate data-driven gating in relation to external hardware gating and regular static image acquisition on PET-MRI data with respect to SUVmax and lesion volumes.

Methods
Sixteen patients with esophageal or gastroesophageal cancer (Siewert I and II) underwent a 6-min PET scan on a Signa PET-MRI system (GE Healthcare) 1.5–2 h after injection of 4 MBq/kg 18F-FDG. External hardware gating was done using a respiratory bellow device, and DDG was performed using MotionFree (GE Healthcare). The DDG raw data files and the external hardware-gating raw files were created on a Matlab-based toolbox from the whole 6-min scan LIST-file. For comparison, two 3-min static raw files were created for each patient. Images were reconstructed using TF-OSEM with resolution recovery with 2 iterations, 28 subsets, and 3-mm post filter. SUVmax and lesion volume were measured in all visible lesions, and noise level was measured in the liver. Paired t-test, linear regression, Pearson correlation, and Bland-Altman analysis were used to investigate difference, correlation, and agreement between the methods.

Results
A total number of 30 lesions were included in the study. No significant differences between DDG and external hardware-gating SUVmax or lesion volumes were found, but the noise level was significantly reduced in the DDG images. Both DDG and external hardware gating demonstrated significantly higher SUVmax (9.4% for DDG, 10.3% for external hardware gating) and smaller lesion volume (− 5.4% for DDG, − 6.6% for external gating) in comparison with non-gated static images.

Conclusions
Data-driven gating with MotionFree for PET-MRI performed similar to external device gating for esophageal lesions with respect to SUVmax and lesion volume. Both gating methods significantly increased the SUVmax and reduced the lesion volume in comparison with non-gated static acquisition. DDG resulted in reduced image noise compared to external device gating and static images.
The impact of child maltreatment on the mental and physical health of child victims: a review of the evidence
Authors: Vizard Eileen , Gray Jenny , Bentovim Arnon 
Published: March 2021

SUMMARYThis article gives a general overview of the current situation in relation to a range of widely recognised and also newly identified types of child maltreatment. The academic and clinical evidence relating to the impact of child maltreatment on the mental and physical health of child victims is substantial and steadily increasing in volume. New types of abuse are being identified, and changing environmental circumstances, which exacerbate the possibility of widely recognised types of child maltreatment occurring, are also being described. These include multi-type maltreatment, female genital mutilation and online child maltreatment. Serious questions may arise regarding neglect of the moral and social development of children and young people who become addicted to online gaming and pornography. Multiple national and local definitions of each of these existing and new forms of maltreatment have been created, some of which are covered here. The impact of these abuses on the physical and mental health and development of child victims in families or settings where abuse or neglect has occurred is discussed.
Experiences of mental health professionals supporting front-line health and social care workers during COVID-19: qualitative study
Authors: Billings Jo , Biggs Camilla , Ching Brian Chi Fung , Gkofa Vasiliki , Singleton David , Bloomfield Michael , Greene Talya 
Published: March 2021

Background
The coronavirus disease 2019 (COVID-19) pandemic is having a well-documented impact on the mental health of front-line health and social care workers (HSCWs). However, little attention has been paid to the experiences of, and impact on, the mental health professionals who were rapidly tasked with supporting them.

Aims
We set out to redress this gap by qualitatively exploring UK mental health professionals’ experiences, views and needs while working to support the well-being of front-line HSCWs during the COVID-19 pandemic.

Method
Mental health professionals working in roles supporting front-line HSCWs were recruited purposively and interviewed remotely. Transcripts of the interviews were analysed by the research team following the principles of reflexive thematic analysis.

Results
We completed interviews with 28 mental health professionals from varied professional backgrounds, career stages and settings across the UK. Mental health professionals were motivated and driven to develop new clinical pathways to support HSCWs they perceived as colleagues and many experienced professional growth. However, this also came at some costs, as they took on additional responsibilities and increased workloads, were anxious and uncertain about how best to support this workforce and tended to neglect their own health and well-being. Many were professionally isolated and were affected vicariously by the traumas and moral injuries that healthcare workers talked about in sessions.

Conclusions
This research highlights the urgent need to consider the mental well-being, training and support of mental health professionals who are supporting front-line workers.