bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of scale, nuclear PDF and temperature variations on the interpretation of medium-modified jet production data from the LHC
Authors: Andronic A. , Honermann J. , Klasen M. , Klein-Bösing C. , Salomon J. 
Published: April 2021

Abstract
In this paper we present a study of in-medium jet modifications performed with JEWEL and PYTHIA 6.4, focusing on the uncertainties related to variations of the perturbative scales and nuclear parton distribution functions (PDFs) and on the impact of the initial and crossover temperature variations of the medium. The simulations are compared to LHC data for the jet spectrum and the nuclear modification factor. We assess the interplay between the choice of nuclear PDFs and different medium parameters and study the impact of nuclear PDFs and the medium on the jet structure via the Lund plane.
The ethics of human-embryoids model: a call for consistency
Authors: Nicolas Paola , Etoc Fred , Brivanlou Ali H. 
Published: April 2021

AbstractIn this article, we discuss the ethics of human embryoids, i.e., embryo-like structures made from pluripotent stem cells for modeling natural embryos. We argue that defining our social priorities is critical to design a consistent ethical guideline for research on those new entities. The absence of clear regulations on these emerging technologies stems from an unresolved debate surrounding natural human embryo research and one common opinion that one needs to solve the question of the moral status of the human embryo before regulating their surrogate. The recent NIH funding restrictions for research on human embryoids have made scientists even more unlikely to raise their voices. As a result, the scientific community has maintained a low profile while longing for a more favorable socio-political climate for their research. This article is a call for consistency among biomedical research on human materials, trying to position human embryoids within a spectrum of existing practice from stem cell research or IVF to research involving human subjects. We specifically note that the current practices in infertility clinics of freezing human embryos or disposing of them without any consideration for their potential benefits contradicts the assumption of special consideration for human material. Conversely, creating human embryoids for research purposes could ensure that no human material be used in vain, always serving humankind. We argue here that it is time to reconsider the full ban on embryo research (human embryos and embryoids) beyond the 14-day rule and that research on those entities should obey a sliding scale combining the completeness of the model (e.g., complete vs. partial) and the developmental stage: with more advanced completeness and developmental stage of the considered entity, being associated with more rigorous evaluation of societal benefits, statements of intention, and necessity of such research.
Derivation and validation of a machine learning risk score using biomarker and electronic patient data to predict progression of diabetic kidney disease
Authors: Chan Lili , Nadkarni Girish N. , Fleming Fergus , McCullough James R. , Connolly Patricia , Mosoyan Gohar , El Salem Fadi , Kattan Michael W. , Vassalotti Joseph A. , Murphy Barbara , Donovan Michael J. , Coca Steven G. , Damrauer Scott M. 
Published: April 2021

Abstract
Aim
Predicting progression in diabetic kidney disease (DKD) is critical to improving outcomes. We sought to develop/validate a machine-learned, prognostic risk score (KidneyIntelX™) combining electronic health records (EHR) and biomarkers.

Methods
This is an observational cohort study of patients with prevalent DKD/banked plasma from two EHR-linked biobanks. A random forest model was trained, and performance (AUC, positive and negative predictive values [PPV/NPV], and net reclassification index [NRI]) was compared with that of a clinical model and Kidney Disease: Improving Global Outcomes (KDIGO) categories for predicting a composite outcome of eGFR decline of ≥5 ml/min per year, ≥40% sustained decline, or kidney failure within 5 years.

Results
In 1146 patients, the median age was 63 years, 51% were female, the baseline eGFR was 54 ml min−1 [1.73 m]−2, the urine albumin to creatinine ratio (uACR) was 6.9 mg/mmol, follow-up was 4.3 years and 21% had the composite endpoint. On cross-validation in derivation (n = 686), KidneyIntelX had an AUC of 0.77 (95% CI 0.74, 0.79). In validation (n = 460), the AUC was 0.77 (95% CI 0.76, 0.79). By comparison, the AUC for the clinical model was 0.62 (95% CI 0.61, 0.63) in derivation and 0.61 (95% CI 0.60, 0.63) in validation. Using derivation cut-offs, KidneyIntelX stratified 46%, 37% and 17% of the validation cohort into low-, intermediate- and high-risk groups for the composite kidney endpoint, respectively. The PPV for progressive decline in kidney function in the high-risk group was 61% for KidneyIntelX vs 40% for the highest risk strata by KDIGO categorisation (p < 0.001). Only 10% of those scored as low risk by KidneyIntelX experienced progression (i.e., NPV of 90%). The NRIevent for the high-risk group was 41% (p < 0.05).

Conclusions
KidneyIntelX improved prediction of kidney outcomes over KDIGO and clinical models in individuals with early stages of DKD.

Graphical abstract
Learning safe neural network controllers with barrier certificates
Authors: Zhao Hengjun , Zeng Xia , Chen Taolue , Liu Zhiming , Woodcock Jim 
Published: April 2021

Abstract
We provide a new approach to synthesize controllers for nonlinear continuous dynamical systems with
control against safety properties. The controllers are based on neural networks (NNs).
To certify the safety property we utilize barrier functions, which are represented by NNs as well.
We train the controller-NN and barrier-NN simultaneously, achieving a verification-in-the-loop synthesis.
We provide a prototype tool nncontroller with a number of case studies.
The experiment results confirm the feasibility and efficacy of our approach.
Gaining a better understanding of the extrusion process in fused filament fabrication 3D printing: a review
Authors: Shaqour Bahaa , Abuabiah Mohammad , Abdel-Fattah Salameh , Juaidi Adel , Abdallah Ramez , Abuzaina Waleed , Qarout Mohammad , Verleije Bart , Cos Paul 
Published: April 2021

AbstractAdditive manufacturing is a promising tool that has proved its value in various applications. Among its technologies, the fused filament fabrication 3D printing technique stands out with its potential to serve a wide variety of applications, ranging from simple educational purposes to industrial and medical applications. However, as many materials and composites can be utilized for this technique, the processability of these materials can be a limiting factor for producing products with the required quality and properties. Over the past few years, many researchers have attempted to better understand the melt extrusion process during 3D printing. Moreover, other research groups have focused on optimizing the process by adjusting the process parameters. These attempts were conducted using different methods, including proposing analytical models, establishing numerical models, or experimental techniques. This review highlights the most relevant work from recent years on fused filament fabrication 3D printing and discusses the future perspectives of this 3D printing technology.
How Much is Enough? Public Perception of Minimum Surgeon Volumes
Authors: Danford Julia M. , Wong Sandra L. , Sirovich Brenda , Underbaake Daniel , Sorensen Meredith J. 
Published: April 2021

AbstractBackgroundA large body of literature supports an association between surgical volumes and outcomes. Research on this subject has resulted in attempts to quantify minimum volume standards for specific surgeries. However, the extent to which the public takes interest in or is able to interpret surgical volume information is not known.MethodsWe designed a 38‐question online survey to assess respondents’ knowledge and beliefs about minimum surgical volume standards, and other factors influencing choice of surgeon. Participants, recruited through Amazon Mechanical Turk, an online crowdsourcing marketplace, were specifically asked to estimate minimum volume standards for four different operations (hernia repair, knee replacement, mitral valve repair, and Whipple) and to assess the implications of specific surgeon volumes for decision‐making in two hypothetical scenarios.ResultsAmong 2024 participants, 81% attested that surgeons should be subject to minimum volume standards. A small minority (19%) reported having prior knowledge of a link between surgeon volumes and outcomes. Respondents’ mean estimates for appropriate minimum annual volumes across four operations were directly correlated with surgical complexity (5 for inguinal hernia repair, 25 for Whipple), while published minimum standards fall with increasing surgical complexity (25 for hernia repair, 5 for Whipple). These findings were validated by participants’ stated intentions: 55% would proceed with a hernia repair by a surgeon with annual volume of 25, while 13% would proceed with a Whipple when annual volume was 5.ConclusionThe concept of minimum surgical volumes is intuitively important to the lay public. However, the general public's skewed expectations of minimum volume standards demonstrate an inability to interpret surgical volume numbers meaningfully in clinical settings without appropriate context.
Towards a replicator dynamics model of age structured populations
Authors: Argasinski K. , Broom M. 
Published: April 2021

AbstractWe present a new modelling framework combining replicator dynamics, the standard model of frequency dependent selection, with an age-structured population model. The new framework allows for the modelling of populations consisting of competing strategies carried by individuals who change across their life cycle. Firstly the discretization of the McKendrick von Foerster model is derived. We show that the Euler–Lotka equation is satisfied when the new model reaches a steady state (i.e. stable frequencies between the age classes). This discretization consists of unit age classes where the timescale is chosen so that only a fraction of individuals play a single game round. This implies a linear dynamics and individuals not killed during the round are moved to the next age class; linearity means that the system is equivalent to a large Bernadelli–Lewis–Leslie matrix. Then we use the methodology of multipopulation games to derive two, mutually equivalent systems of equations. The first contains equations describing the evolution of the strategy frequencies in the whole population, completed by subsystems of equations describing the evolution of the age structure for each strategy. The second contains equations describing the changes of the general population’s age structure, completed with subsystems of equations describing the selection of the strategies within each age class. We then present the obtained system of replicator dynamics in the form of the mixed ODE-PDE system which is independent of the chosen timescale, and much simpler. The obtained results are illustrated by the example of the sex ratio model which shows that when different mortalities of the sexes are assumed, the sex ratio of 0.5 is obtained but that Fisher’s mechanism, driven by the reproductive value of the different sexes, is not in equilibrium.
Two-year efficacy after first transscleral controlled cyclophotocoagulation in patients with and without pseudoexfoliation
Authors: Lenzhofer Markus , Hohensinn Melchior , Hitzl Wolfgang , Steiner Veit , Motaabbed Armin , Motloch Karolina , Colvin Hans Peter , Reitsamer Herbert A. , Moussa Sarah 
Published: April 2021

Abstract
Purpose
Transscleral controlled cyclophotocoagulation (COCO) is a transscleral 810-nm diode laser cyclophotocoagulation that automatically adjusts the applied laser energy utilizing an optical feedback loop. The present study investigates the influence of pseudoexfoliation (PEX) on the efficacy of COCO in a Caucasian study population.

Methods
Retrospective data from 130 consecutive eyes were analyzed during a 2-year follow-up. Baseline characteristics, intraocular pressure (IOP), number of IOP-lowering medications, visual field, best-corrected visual acuity (BCVA), and secondary surgical interventions (SSI) were analyzed. The primary endpoint was IOP reduction at M24 compared to baseline, and the secondary endpoints were IOP course, reduction of IOP-lowering medications, surgical success, and IOP-lowering SSIs stratified by PEX and baseline IOP.

Results
IOP reductions of −35, −39, −25, −25, −23, −34, and −36% could be achieved from baseline to D1, W1, M1, M3, M6, M12, and M24 (all p < 0.001), respectively, while there was a significant overall reduction over time (p < 0.001) in the number of topical IOP-lowering medications postoperatively. The proportion of eyes requiring additional systemic IOP-lowering medication reduced from 31 to 0% at M24 (p = 0.025). Eyes without PEX and IOP < 30 mmHg at baseline had the lowest risk for IOP-lowering SSIs (p < 0.03). BCVA dropped at M12 (0.25 [95% CI: 0.12–0.38]), and the drop persisted during the following 12 months.

Conclusion
The present study demonstrates a midterm IOP-lowering effect after COCO while reducing the burden for topical and systemic IOP-lowering medications. Patients without PEX and IOP < 30 mmHg have a lower risk of SSI. The procedure per se cannot be excluded as causative for the decreased postoperative BCVA. Further prospective investigations are suggested.
Traits of cancer patients and CAM usage
Authors: Dufter Sabine Andrea , Hübner Jutta , Ahmadi Emadaldin , Zomorodbakhsch Bijan 
Published: April 2021

Abstract
Background
The use of Complementary Alternative Medicine (CAM) Methods is increasing and therefore gaining importance also in conventional western medicine. Identifying personal traits to make out by whom and why CAM is used can help physicians in successful physician–patient interaction, and thus improve patient’s compliance and trust towards their physician.

Patients and methods
A questionnaire was passed on to cancer patients in an ambulant clinical and a rehabilitation setting. Multiple regression analyses were run to examine possible predictors for CAM use, such as gender, age, level of education, spirituality, attentiveness, self-efficacy and resilience. To differentiate within CAM users, two dependent variables were created: “holistic and mind–body methods”, such as Yoga, meditation or Homeopathy and “material based methods”, such as food supplements or vitamins.

Results
Higher level of education, younger age and religion-independent attentiveness were significant predictors for the use of “material based methods”. Female gender, higher education and religious spirituality were detected as significant predictors for “holistic and mind–body methods”.

Conclusion
This study is among the first to take a more detailed look at how numerous personal traits are associated with the use of CAM methods and differentiate between the applied methods. Our finding should be considered by conventional health care providers and could be integrated into a holistic assessment, to offer information about complementary medicine and meeting patients’ needs.
Prospective study of hair recovery after (neo)adjuvant chemotherapy with scalp cooling in Japanese breast cancer patients
Authors: Ohsumi Shozo , Kiyoto Sachiko , Takahashi Mina , Takashima Seiki , Aogi Kenjiro , Shimizu Sachie , Doi Miyuki 
Published: April 2021

Abstract
Purpose
Scalp cooling during chemotherapy infusion to mitigate alopecia for breast cancer patients is becoming widespread; however, studies regarding hair recovery after chemotherapy with scalp cooling are limited. We conducted a prospective study of hair recovery after chemotherapy with scalp cooling.

Patients and methods
One hundred and seventeen Japanese female breast cancer patients who completed planned (neo)adjuvant chemotherapy using the Paxman Scalp Cooling System for alopecia prevention were evaluated for alopecia prevention in our prospective study. We evaluated their hair recovery 1, 4, 7, 10, and 13 months after chemotherapy. Primary outcomes were grades of alopecia judged by two investigators (objective grades) and patients’ answers to the questionnaire regarding the use of a wig or hat (subjective grades).

Results
Of 117 patients, 75 completed scalp cooling during the planned chemotherapy cycles (Group A), but 42 discontinued it mostly after the first cycle (Group B). Objective and subjective grades were significantly better in Group A than in Group B throughout 1 year, and at 4 and 7 months after chemotherapy. When we restricted patients to those with objective Grade 3 (hair loss of > 50%) at 1 month, Group A exhibited slightly faster hair recovery based on the objective grades than Group B. There was less persistent alopecia in Group A than in Group B.

Conclusions
Scalp cooling during chemotherapy infusion for Japanese breast cancer patients increased the rate of hair recovery and had preventive effects against persistent alopecia.
Deep learning approaches to pattern extraction and recognition in paintings and drawings: an overview
Authors: Castellano Giovanna , Vessio Gennaro 
Published: April 2021

AbstractThis paper provides an overview of some of the most relevant deep learning approaches to pattern extraction and recognition in visual arts, particularly painting and drawing. Recent advances in deep learning and computer vision, coupled with the growing availability of large digitized visual art collections, have opened new opportunities for computer science researchers to assist the art community with automatic tools to analyse and further understand visual arts. Among other benefits, a deeper understanding of visual arts has the potential to make them more accessible to a wider population, ultimately supporting the spread of culture.
The provenance signal of climate–tectonic interactions in the evolving St. Elias orogen: framework component analysis and pyroxene and epidote single grain geochemistry of sediments from IODP 341 sites U1417 and U1418
Authors: Huber Barbara , Bahlburg Heinrich 
Published: April 2021

AbstractThe St. Elias orogen and the Surveyor Fan in the adjacent Gulf of Alaska are a coupled source to sink system recording the interplay of tectonics and variable degrees of glaciation during the collision of the Yakutat terrane with the southern Alaska margin since the Miocene. The Miocene to Holocene sediments of the Surveyor Fan were drilled during IODP expedition 341. The recovered material is used to constrain information on changes in erosion centers during the last 10 Ma to study the impact of climatic and tectonic processes on orogen evolution. Point counting of sand- and silt-sized light framework components and geochemical single grain analysis of heavy mineral groups epidote and pyroxene is applied to analyze patterns of sedimentary provenance of two sites on the distal and proximal Surveyor Fan (Site U1417 and U1418, respectively). The studied sands and silts of Miocene to Pleistocene age are slightly enriched in feldspar (plag >> kf) at the proximal site, compositions at both sites do not show systematical changes with time of deposition. Framework component spectra uniformly reflect the expected active margin provenance. Epidote and pyroxene compositions are very consistent and show no change with time of deposition. Associations of epidote and pyroxene with albite, titanite and pumpellyite are in line with near-shore sources in the Chugach Metamorphic Complex and the metabasite belt at its southern border, and in units of recycled detritus exposed in the fold and thrust belt on the western Yakutat Terrane, respectively. Rock fragments indicate input from mainly metamorphic sources during the Miocene and Pliocene and an increase of input from low-grade metamorphic and sedimentary rocks in the Pleistocene, a finding also indicated by the abundance of epidote and pyroxene. This implies increasing erosion of the near-shore areas of the fold and thrust belt with advance of glaciers to the shore since the Miocene, being enhanced by the onset of the Northern Hemisphere glaciation at the beginning of the Pleistocene. Climate changes connected to the mid-Pleistocene transition did not result in appreciable changes in the petrographic compositions. Glaciers seem to have remained nested in their topographically predefined positions, continuously feeding material with uniform characteristics into the fan.
Ion-to-electron capacitance of single-walled carbon nanotube layers before and after ion-selective membrane deposition
Authors: Zdrachek Elena , Bakker Eric 
Published: April 2021

AbstractThe capacitance of the ion-to-electron transducer layer helps to maintain a high potential stability of solid-contact ion-selective electrodes (SC-ISEs), and its estimation is therefore an essential step of SC-ISE characterization. The established chronopotentiometric protocol used to evaluate the capacitance of the single-walled carbon nanotube transducer layer was revised in order to obtain more reliable and better reproducible values and also to allow capacitance to be measured before membrane deposition for electrode manufacturing quality control purposes. The capacitance values measured with the revised method increased linearly with the number of deposited carbon nanotube–based transducer layers and were also found to correlate linearly before and after ion-selective membrane deposition, with correlation slopes close to 1 for nitrate-selective electrodes, to 0.7 and to 0.5 for potassium- and calcium-selective electrodes.
Graphical abstract
Radiotherapy versus combination radiotherapy-bevacizumab for the treatment of recurrent high-grade glioma: a systematic review
Authors: Kulinich Daniel P. , Sheppard John P. , Nguyen Thien , Kondajji Aditya M. , Unterberger Ansley , Duong Courtney , Enomoto Adam , Patel Kunal , Yang Isaac 
Published: April 2021

AbstractBackgroundHigh-grade gliomas (HGG) comprise the most common primary adult brain cancers and universally recur. Combination of re-irradiation therapy (reRT) and bevacizumab (BVZ) therapy for recurrent HGG is common, but its reported efficacy is mixed.ObjectiveTo assess clinical outcomes after reRT ± BVZ in recurrent HGG patients receiving stereotactic radiosurgery (SRS), hypofractionated radiosurgery (HFSRT), or fully fractionated radiotherapy (FFRT).MethodsWe performed a systematic review of PubMed, Web of Science, Scopus, Embase, and Cochrane databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We identified studies reporting outcomes for patients with recurrent HGG treated via reRT ± BVZ. Cohorts were stratified by BVZ treatment status and re-irradiation modality (SRS, HFSRT, and FFRT). Outcome variables were overall survival (OS), progression-free survival (PFS), and radiation necrosis (RN).ResultsData on 1399 patients was analyzed, with 954 patients receiving reRT alone and 445 patients receiving reRT + BVZ. All patients initially underwent standard-of-care therapy for their primary HGG. In a multivariate analysis that adjusted for median patient age, WHO grade, RT dosing, reRT fractionation regimen, time between primary and re-irradiation, and re-irradiation target volume, BVZ therapy was associated with significantly improved OS (2.51, 95% CI [0.11, 4.92] months,P= .041) but no significant improvement in PFS (1.40, 95% CI [− 0.36, 3.18] months,P= .099). Patients receiving BVZ also had significantly lower rates of RN (2.2% vs 6.5%,P< .001).ConclusionsCombination of reRT + BVZ may improve OS and reduce RN rates in recurrent HGG, but further controlled studies are needed to confirm these effects.