bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public Policies, Gaps and Digital Literacy of the Elderly People
Authors: Riveros Carolina , Arenas Ángela , Castro Marcela , Olivares Maximiliano 
Published: June 2021

Purpose ”“ In the current development of Chilean society there is a profound socio-demographic transformation, which implies an advanced aging of the population.
Methodology ”“ According to the 2017 Census, 17.7 percent - equivalent to 1,586,634 women - are 60 years of age or older, while men in the same age group account for 14.7 percent (1,263,537). This age group constitutes an enormous challenge for the design of public policies.
Findings ”“ It is necessary to generate access policies that take into account the different educational levels of older people in order to overcome the digital divide, as well as incentives for skills and competencies in the various uses and benefits currently provided by ICTs.
PERIODIZATION OF THE DEVELOPMENT OF OUT- OF - SCHOOL EDUCATION OF UKRAINE (SECOND HALF OF the XX - BEGINNING OF the XXI CENTURY)
Authors: Kostenko L. 
Published: June 2021

The author singles out and characterizes periods of the development of out-of-school education in Ukraine (second half of the XX – beginning of the XXI century) – the period of the Soviet time (1952–1990) and the period of Ukraine as an independent state (1991–2014), the differences of which are determined by socio-political and socio-economic condition of the country. The publication identifies the main types of out-of-school institutions, the content, forms and methods of out-of-school education in each of the mentioned periods of its development.The author concludes that despite all the socio-political and historical difficulties, the system of out-of-school education in Ukraine (1952-2014) had positive trends in the formation of this component of continuous learning and in the direct impact on the individual.Key words: out-of-school education, development of out-of-school education, periods of development of out-of-school education, content of out-of-school education, forms of organization of out-of-school education, methods of out-of-school education, out-of-chool institution.
PROBLEMS OF ENVIRONMENTAL TERMINOLOGY TRANSLATION BY STUDENTS IN THE PROCESS OF STUDYING FOREIGN LANGUAGE IN HIGHER EDUCATIONAL INSTITUTION
Authors: Kulko V. , Horbanova O. , Biryukova D. 
Published: June 2021

The analysis of the problem of environmental terminology translation by students in the process of studying foreign language in higher educational institutions is given. On the basis of scientific research by prominent scientists, the essence of the concepts of "term" and "ecological term" is analyzed. The main attention is devoted to the study of the causes arising during the translation of the environmental sphere terms. Some aspects of simplifying the process of terms translation are considered. Further research in this area is possible in order to find sources of English and Ukrainian environmental terminology origin.Key words: term, ecological term, terminology system, ecology, term definition, environmental protection, simple term, derivative term.Кулько В. А., Горбаньова О. О., кандидат філологічних наук Бірюкова Д. В. Проблеми перекладу екологічної термінології студентами в процесі вивчення іноземної мови у ВНЗ / Університет митної справи та фінансів, Україна, ДніпроВ даній статті надано аналіз проблеми перекладу екологічної термінології студентами в процесі вивчення іноземної мови у ВНЗ. На основі наукових досліджень видатних вчених проаналізовано сутність понять «термін» та «екологічний термін». Основну увагу приділено дослідженню причин, які виникають у студентів під час перекладу термінів екологічної сфери. Розглянуто деякі аспекти щодо спрощення процесу перекладу термінів. Подальші дослідження в цій області можливі з метою пошуку джерел походження англійської та української екологічної термінології.Ключові слова: термін, екологічний термін, термінологічна система, екологія, дефініції терміна, охорона навколишнього середовища, простий термін, похідний термін.
Neuroscience in the teaching of English
Authors: Mendez Aguilera Pedro Julio , Carabajo Romero Italo Rigoberto , Vergara Mendoza Ketty Zoraida 
Published: June 2021

This study seeks to give an approximation to the role of the use of neuroscience in the teaching of the English language, to create educational resources to a language with a communicative approach teaching and reflecting on the implementation of methodological strategies congruent to modern education, is made a revision to new contributions in the pedagogical field, which include neural studies to see more closely how it develops and mature central nervous system and the brain, so now that the emphasis on learning a foreign language has become popular in recent decades, arduous way seeks to methodological strategies and activities to enhance their learning, which in this study proposes the use of six teaching strategies based on knowledge of how the brain, which are a contribution to reduce the educational gap between the old and the new school.I conducted this study is with teachers of English from the University of Agraria del Ecuador. The correlational descriptive method is used and as results were obtained that the relationship between the studied variables is positive.
Resistencia de los preservativos masculinos de látex y su efecto a la exposición en temperaturas menores o iguales a 40°c
Authors: Rivas Condo Jackson Robert , Rivas Condo Fernanda Carolina , Miranda Laborda María José , Pizarro Maldonado Pía Paulette , Valencia Camacho Luis Fernando , Quezada Correa Gilda Cecibel , Quiñonez Guerrero Rosangela Mirelly , Loor Rivas Maybe Dayana 
Published: June 2021

Determinamos la alteración de la resistencia del látex y por ende la efectividad de anticoncepción de los preservativos cuando son expuestos a temperaturas altas, se comprobó si en esos casos los preservativos se dilatan por la presencia de calor y puedan romperse con más facilidad.
En este experimento se usó un grupo control y un grupo tratamiento para determinar si se produce o no un cambio comparativo entre la longitud de los preservativos de ambos grupos, luego de simular una relación sexual mediante dos fases, a temperatura ambiente y luego a 40°C de temperatura, en todos los casos se aplicó fricción por 3 min.
Luego de aplicarse fricción se hizo la comparación entre las longitudes finales del grupo control y del grupo tratamiento determinando que no se afecta la resistencia de los preservativos al aplicarle el tratamiento, puesto a que la diferencia entre la media aritmética de las longitudes de ambos grupos fue insignificante. El método estadístico usado para evaluar la elasticidad entre el grupo control y el grupo tratamiento fue T de Student, con una significancia de 5%; se pudo negar nuestra hipótesis inicial que fue: el preservativo se alarga al ser sometido en agua a temperatura de 40ºC posteriormente a la fricción aplicada. Este resultado puede estar relacionado a errores aleatorios como la variación de fricción aplicada a cada preservativo.
Interculturalidad e integración social en el aula a través del flamenco y los medios audiovisuales. Orientaciones y propuestas didácticas
Authors: Escudero Díaz Juan Pedro 
Published: June 2021

La integración y armonía de todos los elementos que componen el hecho educativo (profesor-alumno-aula) se hace necesaria para que el proceso de enseñanza-aprendizaje se lleve a cabo con la mayor probabilidad de éxito posible. Por ello están surgiendo multitud de recursos y herramientas para la mejora de la convivencia en el aula y la transmisión de valores como el respeto, la tolerancia, el diálogo, etc. Siendo el flamenco una de las manifestaciones folklóricas y socioculturales que ha nacido gracias a las influencias de diferentes pueblos, su presencia en el aula puede resultar un instrumento eficaz y productivo. Los medios audiovisuales y las nuevas tecnologías pueden servirnos de vehículo entre el flamenco y el alumnado, el cual está habituado al uso cotidiano de estos medios. Con la combinación de ambos recursos (flamenco-medios audiovisuales) se potenciarán competencias educativas básicas recogidas en el currículum como el tratamiento de la información y competencia digital o la competencia social y ciudadana. Esta comunicación ofrecerá diversas orientaciones y propuestas didácticas para trabajar especialmente la integración social en el aula a través del flamenco y los medios audiovisuales, valorando las posibilidades reales que ofrecen y sus aplicaciones docentes.
Las Directoras de Orquesta como ejemplo de liderazgo femenino
Authors: Querol Gutiérrez Cristina 
Published: June 2021

La historia está marcada profundamente por el patriarcado. Esto implica que desde el inicio de la humanidad se ha generado una estructura social y cultural asentada en el predominio de una parte de la población sobre otra por razón de sexo. Como seres sociales que somos nos organizamos, y en toda organización social es necesaria una coordinación de los diversos componentes que en ella participan. Ese papel de coordinación lo asume el lider. La presencia de mujeres ocupando posiciones de dirección sigue siendo escasa y excepcional. Los motivos de esta discriminación son muchos, uno de ellos se lo impone la misma mujer, el "techo de cristal". La orquesta es una organización formada por unos cien músicos, altamente especializados. Puede considerarse como una empresa, que como todas los organizaciones necesitan de un coordinador, el director. El mundo de la música clásica estaba dominado por el sexo masculino, aunque estudiaban muchas mujeres, profesionalmente destacaban los hombres. Era impensable hace unos años encontrar a directoras de orquesta, pero a medida que la mujer ha empezado hacer valer sus derechos y adquirir su espacio en todos los campos, en la música ha ido ganando terreno también y por supuesto en la dirección orquestal.
PENGENDALIAN KUALITAS PRODUK PINTU KAYU MENGGUNAKAN METODE LEAN SIX SIGMA
Authors: Hermansyah Dede 
Published: June 2021

Pintu kayu merupakan produk unggulan yang ditujukan untuk dapat memenuhi kebutuhan ekspor hasil hutan. Permaslahan yang seringkali ditemui oleh perusahaan adalah terjadinya kecacatan produk dalam proses produksi pintu kayu serta ditemukannyabeberapa aktivitas yang termasuk tidak memberikan efek nilai tambah. Bentuk kecacatan yang umumnya ditemukan pada pintu kayu diantaranya ketidak sempurnaan proses perakitan, pengeleman, dan pewarnaan. Penelitian ini memiliki tujuan untuk menghasilkan perbaikankualitas pintukayudengan cara meminimalkan produk cacat. Lean Six Sigma digunakan sebagai metode mengidentifikasi penyebab kecacatan. Hasil analisis menunjukan bahwa faktor utama dari kecacatan disebabkan oleh kurang terampilnya operator serta adanya gangguan mesin saat pengoperasian sehingga produk tidak sesuai dengan kualitas yang diharapkan. Usulan perbaikan untuk mengatasi permasalahan ini adalahmemberikan pelatihan dan ketrampilan kerjabagi operator, menyusun jadwal rencana perawatan mesin dan membuat prosedur aktifitas produksi pada bagian pengeleman, pewarnaan dan bagian perakitan.
L5 nerve root injury caused by anterolateral malpositioning of loosened S1 pedicle screws: illustrative cases
Authors: Tamagawa Shota , Okuda Takatoshi , Nojiri Hidetoshi , Momomura Rei , Ishijima Muneaki 
Published: June 2021

BACKGROUND
Although malpositioning of pedicle screws into the spinal canal and intervertebral foramen can cause spinal nerve root injuries, there are few reports of L5 nerve root injuries when S1 pedicle screws have been inserted anterolaterally. The authors report two cases of L5 nerve root injury caused by anterolateral malpositioning of loosened S1 pedicle screws.

OBSERVATIONS
In both patients, S1 pedicle screws were inserted toward the outside of the S1 anterior foramen, and the tip of the screws perforated the anterior sacral cortex. L5 nerve root impairment was not observed immediately after surgery. However, severe leg pain in the L5 area was observed after the S1 pedicle screws became loosened. In case 1, the symptoms could not be controlled with conservative treatment. Reoperation was performed 3 months after the initial surgery. In case 2, the symptoms gradually improved with conservative treatment because the area around the loosened S1 screw was surrounded by newly formed bone that stabilized the screws, as observed with computed tomography 1 year after surgery.

LESSONS
Surgeons should recognize that anterolateral malpositioning of S1 pedicle screws can cause L5 nerve root injury. The screws should be inserted in the correct direction without loosening.
Sox9 Determines Translational Capacity During Early Chondrogenic Differentiation of ATDC5 Cells by Regulating Expression of Ribosome Biogenesis Factors and Ribosomal Proteins
Authors: Caron Marjolein M. J. , Eveque Maxime , Cillero-Pastor Berta , Heeren Ron M. A. , Housmans Bas , Derks Kasper , Cremers Andy , Peffers Mandy J. , van Rhijn Lodewijk W. , van den Akker Guus , Welting Tim J. M. 
Published: June 2021

IntroductionIn addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early and a late (extracellular matrix associated) phase expression. In this study, we aimed to determine what biological processes are driven by Sox9 during this early phase of chondrogenic differentiation.MaterialsSox9 expression in ATDC5 cells was knocked down by siRNA transfection at the day before chondrogenic differentiation or at day 6 of differentiation. Samples were harvested at 2 h and 7 days of differentiation. The transcriptomes (RNA-seq approach) and proteomes (Label-free proteomics approach) were compared using pathway and network analyses. Total protein translational capacity was evaluated with the SuNSET assay, active ribosomes were evaluated with polysome profiling, and ribosome modus was evaluated with bicistronic reporter assays.ResultsEarly Sox9 knockdown severely inhibited chondrogenic differentiation weeks later. Sox9 expression during the immediate early phase of ATDC5 chondrogenic differentiation regulated the expression of ribosome biogenesis factors and ribosomal protein subunits. This was accompanied by decreased translational capacity following Sox9 knockdown, and this correlated to lower amounts of active mono- and polysomes. Moreover, cap- versus IRES-mediated translation was altered by Sox9 knockdown. Sox9 overexpression was able to induce reciprocal effects to the Sox9 knockdown.ConclusionHere, we identified an essential new function for Sox9 during early chondrogenic differentiation. A role for Sox9 in regulation of ribosome amount, activity, and/or composition may be crucial in preparation for the demanding proliferative phase and subsequent cartilage extracellular matrix production of chondroprogenitors in the growth platein vivo.
Effects of Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction in Patients Undergoing Peritoneal Dialysis
Authors: Fu Sha , Xu Zhenjian , Lin Baojuan , Chen Junzhe , Huang Qiuyan , Xu Yanchun , Xu Anping , Chen Yangxin , Tang Ying 
Published: June 2021

Aims: The effect of the angiotensin receptor–neprilysin inhibitor (ARNI) sacubitril-valsartan in patients with heart failure with preserved ejection fraction (HFpEF) remains unclear, and data on ARNI treatment in peritoneal dialysis (PD) patients are lacking. The present study was designed to assess the efficacy and safety of sacubitril-valsartan in patients with HFpEF undergoing peritoneal dialysis.Methods and Results: End-stage kidney disease (ESKD) patients undergoing PD for 3 months with New York Heart Association (NYHA) class II–IV heart failure, ejection fraction of 50% or higher, and elevated levels of N-terminal pro–B-type natriuretic peptide (NT-proBNP) were assigned to receive sacubitril-valsartan. Patients were followed up regularly after medication treatment. The alterations in clinical and biochemical parameters before and after taking sacubitril-valsartan (generally 50–100 mg b.i.d) were investigated, and safety was also assessed. Twenty-one patients were recruited in this study. Compared with baseline levels, NT-proBNP levels [9769.0 (3093.5–21941.0) vs. 3034.0 (1493.2–6503.0), P = 0.002], and heart rate [80.0 (74.5–90.5) vs. 75.0 (70.3–87.0), P = 0.031] were markedly decreased after treatment with sacubitril-valsartan. Signs and symptoms of heart failure (21/21 vs. 15/21, P = 0.021) were obviously alleviated, NYHA classification and E/e' ratio showed a notable trend of improvement after 3–12 months of follow-up. None of the patients showed adverse drug reactions.Conclusions: The present data suggested that sacubitril-valsartan treatment in patients with HFpEF undergoing PD was effective and safe.
Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age
Authors: Jansen Lisette , Peeters-Scholte Cacha M. P. C. D. , Berg-Huysmans Annette A. van den , Klink Jeanine M. M. van , Rijken Monique , Egmond-van Dam Janneke C. van , Vermeiren Robert R. J. M. , Steggerda Sylke J. 
Published: June 2021

Objective: To investigate the rate and stability of impairments in children born preterm by assessing (1) early and school-age outcome in four developmental domains and (2) individual changes in outcome at both timepoints.Design: Prospective, longitudinal cohort study in children born in 2006–2007, &lt;32 weeks' gestation. Follow-up at 2 and 10 years of age included standardized neurological, motor, cognitive and behavioral assessments. Children were categorized as having no, mild or moderate-severe impairment in these four domains. A composite impairment score was composed and the number of domains with impairments counted. For each child, individual outcomes at both timepoints were compared.Results: Follow-up at both time-points was available in 71/113(63%) children. At group level, there were no significant changes in the severity of impairments per domain. However, at individual level, there were less children with a mild abnormal composite score at 10 years of age (44 vs. 20%; p = 0.006), and more with a moderate-severe abnormal composite score (12 vs. 35%; p = 0.001). Especially children with normal/mild outcome at 2 years were likely to shift to other outcome categories over time.Conclusions: Children with early severe impairment are likely experiencing impairments later on, but early normal/mild abnormal outcomes should be interpreted with care, considering the large individual shifts over time. Long-term follow-up in all children born very preterm should therefore be continued to at least school-age.
Mice Lacking GABAA Receptor δ Subunit Have Altered Pharmaco-EEG Responses to Multiple Drugs
Authors: Grotell Milo , Abdurakhmanova Shamsiiat , Elsilä Lauri V. , Korpi Esa R. 
Published: June 2021

In the brain, extrasynaptically expressed ionotropic, δ subunit-containing γ-aminobutyric acid A-type receptors (δ-GABAARs) have been implicated in drug effects at both neuronal and behavioral levels. These alterations are supposed to be caused via drug-induced modulation of receptor ionophores affecting chloride ion-mediated inhibitory tonic currents. Often, a transgenic mouse model genetically lacking the δ-GABAARs (δ-KO) has been used to study the roles of δ-GABAARs in brain functions, because a specific antagonist of the δ-GABAARs is still lacking. We have previously observed with these δ-KO mice that activation of δ-GABAARs is needed for morphine-induced conditioning of place preference, and others have suggested that δ-GABAARs act as targets selectively for low doses of ethanol. Furthermore, activation of these receptors via drug-mediated agonism induces a robust increase in the slow-wave frequency bands of electroencephalography (EEG). Here, we tested δ-KO mice (compared to littermate wild-type controls) for the pharmaco-EEG responses of a broad spectrum of pharmacologically different drug classes, including alcohol, opioids, stimulants, and psychedelics. Gaboxadol (THIP), a known superagonist of δ-GABAARs, was included as the positive control, and as expected, δ-KO mice produced a blunted pharmaco-EEG response to 6 mg/kg THIP. Pharmaco-EEGs showed notable differences between treatments but also differences between δ-KO mice and their wild-type littermates. Interestingly mephedrone (4-MMC, 5 mg/kg), an amphetamine-like stimulant, had reduced effects in the δ-KO mice. The responses to ethanol (1 g/kg), LSD (0.2 mg/kg), and morphine (20 mg/kg) were similar in δ-KO and wild-type mice. Since stimulants are not known to act on δ-GABAARs, our findings on pharmaco-EEG effects of 4-MMC suggest that δ-GABAARs are involved in the secondary indirect regulation of the brain rhythms after 4-MMC.
Did the UK COVID-19 Lockdown Modify the Influence of Neighbourhood Disorder on Psychological Distress? Evidence From a Prospective Cohort Study
Authors: Teo Celine , Kim Chungah , Nielsen Andrew , Young Thomas , O'Campo Patricia , Chum Antony 
Published: June 2021

Background: National lockdown in the UK during the COVID-19 pandemic severely restricted the mobility of residents and increased time spent in their residential neighbourhoods. This is a unique opportunity to understand how an exogenous factor that reduces mobility may influence the association between neighbourhood social environment and mental health. This study investigates whether the COVID-19 lockdown may modify the effect of neighbourhood disorder on psychological distress.Methods: We tracked changes in psychological distress, using the UK household longitudinal survey across the pre-COVID and lockdown periods in 16,535 adults. Neighbourhood disorder was measured along two subscales: social stressors and property crime. Fixed-effects regression was used to evaluate whether the widespread reduction in mobility modifies the association between the subscales of neighbourhood disorder and psychological distress.Results: The effect of neighbourhood social stressors on psychological distress was stronger in the lockdown period compared to the pre-COVID period. Compared to the pre-COVID period, the effect of being in neighbourhoods with the highest social stressors (compared to the lowest) on psychological distress increased by 20% during the lockdown. Meanwhile, the effect of neighbourhood property crime on mental health did not change during the lockdown.Conclusion: The sudden loss of mobility as a result of COVID-19 lockdown is a unique opportunity to address the endogeneity problem as it relates to mobility and locational preferences in the study of neighbourhood effects on health. Vulnerable groups who have limited mobility are likely more sensitive to neighbourhood social stressors compared to the general population.