bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONCEPÇÕES DO JORNALISMO TRANSMÍDIA – EM BUSCA DE UM CONCEITO
Authors: Martins Elaide , Duarte Glenda Suelem Magno 
Published: January 2021

O objetivo deste trabalho é compreender o conceito de jornalismo transmídia a partir das seguintes vertentes: narrativa, linguagem e estratégia, partindo-se de pesquisadores que adotam o termo jornalismo transmídia, como Ford (2007), Moloney (2011), Martins (2012, 2015), Canavilhas (2013), Tárcia (2013), Martins, Castro e Fecury Vinagre (2017, 2018), dentre outros. A escolha metodológica é de caráter qualitativo por meio de revisão bibliográfica e análise de dois produtos jornalísticos autodenominados transmidiáticos: o Especial Transmídia do Portal “O Dia”, do Piauí; e o “Projeto 100”, da Agência Pública. Os principais resultados apontam para a compreensão do conceito a partir das regularidades presentes nessas distintas concepções, a fim de elucidar esse novo modo de jornalismo.

PALAVRAS-CHAVE: Jornalismo transmídia; narrativa, linguagem e estratégia; “O Dia”; “Projeto 100”.

ABSTRACT
The objective of this work is to understand the concept of transmedia journalism from the following aspects: narrative, language and strategy, starting from researchers who adopt the term transmedia journalism, such as Ford (2007), Moloney (2011), Martins (2012, 2015), Canavilhas (2013), Tárcia (2013), Martins, Castro and Fecury Vinagre (2017, 2018), among others. The methodological choice is qualitative in nature through a literature review and analysis of two self-styled transmedia journalistic products: the Transmedia Special of the Portal "O Dia", from Piauí; and the "Project 100", from the Public Agency. The main results point to the understanding of the concept from the regularities present in these different conceptions, in order to elucidate this new mode of journalism.
KEYWORDS: Transmedia journalism; narrative, language and strategy; "The Day"; "Project 100".

RESUMEN
El objetivo de este trabajo es entender el concepto de periodismo transmedia desde los siguientes aspectos: narrativa, lenguaje y estrategia, a partir de investigadores que adoptan el término periodismo transmedia, como Ford (2007), Moloney (2011), Martins (2012, 2015), Canavilhas (2013), Tárcia (2013), Martins, Castro y Fecury Vinagre (2017, 2018), entre otros. La elección metodológica es de carácter cualitativo a través de la revisión de la literatura y el análisis de dos productos periodísticos autodenominados transmedia: el Especial Transmedia del Portal "O Dia", de Piauí; y el "Proyecto 100", de la Agencia Pública. Los principales resultados apuntan a la comprensión del concepto a partir de las regularidades presentes en estas diferentes concepciones, con el fin de dilucidar esta nueva forma de periodismo.
PALABRAS CLAVE: Periodismo transmedia; narrativa, lenguaje y estrategia; "El Día"; "Proyecto 100".
Evaluation of cost-effective thin modified binder seals on Nano-Modified Emulsion (NME) stabilised base layers using Accelerated Pavement Testing (APT)
Authors: Jordaan Gerrit J , Steyn Wynand J VdM , Broekman Andre 
Published: January 2021

Emulsion stabilisation of base layers surfaced with chip seals often proves problematic with chips punching into the base and early distress. This can be aggravated by the use of modified binders that restricts the evaporation of moisture from pavement layers. The introduction of New-age (Nano) Modified Emulsion (NME) stabilisation has the advantage that water is chemically repelled from the stabilised layer resulting in an accelerated development of strength. A need was identified to evaluate the early life performance of selected chip seals, together with identified binders. Three different chip seal surfacings with unconventional modified binders were constructed and evaluated using Accelerated Pavement Testing (APT) with the MMLS3. The objectives of the experimental design and testing were to evaluate binder performance, early loss of chips before chip orientation at low temperatures, punching of the chips into the NME stabilised base, deformation characteristics of a Cape seal and the effect of the use of a standard normal modified binder. This paper contains details of the NME base layer, the binder and seal selection and the test results. It is shown that a cost-effective thin chip seal in combination with a suitable binder can be used on a NME stabilised base with confidence.
Optimal Algorithm Selection in Multimodal Medical Image Registration
Authors: Elkeshreu Husein , Basir Otman 
Published: January 2021

Many medical applications benefit from the diversity inherent in imaging technologies to obtain more reliable diagnoses and assessments. Typically, the images obtained from multiple sources are acquired at distinct times and from different viewpoints, rendering a multitude of challenges for the registration process. Furthermore, different areas of the human body require disparate registration functional capabilities and degrees of accuracy. Thus, the benefit attained from the image multiplicity hinges heavily on the imaging modalities employed as well as the accuracy of the alignment process. It is no surprise then that a wide range of registration techniques has emerged in the last two decades. Nevertheless, it is widely acknowledged that despite the many attempts, no registration technique has been able to deliver the required accuracy consistently under diverse operating conditions. This paper introduces a novel method for achieving multimodal medical image registration based on exploiting the complementary and competitive nature of the algorithmic approaches behind a wide range of registration techniques. First, a thorough investigation of a wide range of registration algorithms is conducted for the purpose of understanding and quantifying their registration capabilities as well as the influence of their control parameters. Subsequently, a supervised randomized machine learning strategy is proposed for selecting the best registration algorithm for a given registration instance, and for determining the optimal control parameters for such algorithm. Several experiments have been conducted to verify the capabilities of the proposed selection strategy with respect to registration reliability, accuracy, and robustness.
Continuous use of glycomacropeptide in the nutritional management of patients with phenylketonuria: a clinical perspective
Authors: Pena Maria João , Pinto Alex , de Almeida Manuela Ferreira , Barbosa Catarina de Sousa , Ramos Paula Cristina , Rocha Sara , Guimas Arlindo , Ribeiro Rosa , Martins Esmeralda , Bandeira Anabela , Dias Cláudia Camila , MacDonald Anita , Borges Nuno , Rocha Júlio César 
Published: January 2021

Abstract
Background: In phenylketonuria (PKU), modified casein glycomacropeptide supplements (CGMP-AA) are used as an alternative to the traditional phenylalanine (Phe)-free L-amino acid supplements (L-AA). However, studies focusing on the long-term nutritional status of CGMP-AA are lacking. This retrospective study evaluated the long-term impact of CGMP-AA over a mean of 29 months in 11 patients with a mean age at CGMP-AA onset of 28 years (range 15 to 43) [8 females; 2 hyperphenylalaninaemia (HPA), 3 mild PKU, 3 classical PKU and 3 late-diagnosed]. Outcome measures included metabolic control, anthropometry, body composition and biochemical parameters. Results: CGMP-AA, providing 66% of protein substitute intake, was associated with no significant change in blood Phe with CGMP-AA compared with baseline (562 ± 289 µmol/L vs 628 ± 317 µmol/L; p=0.065). In contrast, blood tyrosine significantly increased on CGMP-AA (52.0 ± 19.2 μmol/L vs 61.4 ± 23.8 μmol/L; p=0.027). Conclusions: Biochemical nutritional markers remained unchanged which is an encouraging finding in adults with PKU, many of whom are unable to maintain full adherence with nutritionally fortified protein substitutes. Longitudinal, prospective studies with larger sample sizes are necessary to fully understand the metabolic impact of using CGMP-AA in PKU.
Primate Speciation Links to Massive and Directional Shrinkage of the Dinucleotide Short Tandem Repeat Compartment.
Authors: Arabfard Masoud , Salesi Mahmood , Arabipour Iman , Najafipour Reza , Delbari Ahmad , Khorshid Hamid Reza Khorram , Ohadi Mina 
Published: January 2021

Abstract
The evolutionary trend of short tandem repeats (STRs) at the crossroads of speciation remains largely elusive and attributed to random evolution for the most part. Here we investigated the dinucleotide STR compartment in primate speciation. We selected six species, which shared sequential chronological ancestors, including mouse, macaque, gorilla, chimpanzee, bonobo, and human, and collected three sets of data on the abundance of all classes of dinucleotide STRs (≥6-repeats) for three regions of every chromosome, each region spanning 10 Mb of DNA. In all three datasets, we found consistent directional shrinkage of the dinucleotide STR compartment in all the primate species selected vs. mouse, as follows: mouse>macaque>great apes. The >20-repeat STRs were the most significantly affected as a result of this shrinkage. We propose that massive and directional shrinkage of the dinucleotide STR compartment had a decisive link with primate speciation. This is a prime instane of massive directional STR trend in multiple speciation.
Comparison of early clinical results for the femoral neck system and cannulated screws in the treatment of unstable femoral neck fractures
Authors: Zhou Xiaoqiang , Li Zhiqiang , Xu Renjie , She Yuanshi , Zhang Xiangxin , Chen Guangxiang , Yu Xiao 
Published: January 2021

Abstract
Objective: To compare early clinical effects of the femoral neck system (FNS) and three cannulated screws for the treatment of patients with unstable femoral neck fractures.
Methods: A retrospective analysis with pair matching of 81 patients who received FNS or cannulated screw internal fixation for Pauwels type-3 femoral neck fracture in our hospital from January 2019 to December 2019 was conducted. Patients who received FNS were the test group, and those who received cannulated screws comprised the control group. Matching requirements were as follows: same sex, similar age and similar body mass index (BMI). A total of 30 pairs were successfully matched, and the average age was 53.84 years. The operation time, intraoperative blood loss, hospital stay, hospitalization cost, postoperative visual analogue scale (VAS) score, time to walking without crutches, Harris score, femoral head necrosis rate and complication rate were compared between the groups.
Results: Postoperative re-examination of radiographs showed satisfactory reduction in all patients, and all patients were followed up for 10-22 months. Those in the FNS group had lower postoperative VAS scores, earlier times to walking without crutches, higher Harris scores at the last follow-up and lower complication rates (P<0.05). However, intraoperative blood loss and hospitalization costs were greater in the FNS group (P<0.05). No statistically significant difference in operation time, hospital stay or femoral head necrosis rate was observed between the two groups (P>0.05).
Conclusion: For patients with unstable femoral neck fractures, FNS has better clinical efficacy than cannulated screws, though it is also more expensive. The excellent biomechanical performance and clinical efficacy of FNS make it a new choice for the treatment of unstable femoral neck fractures.
Interfacial electrostatic interaction-enhanced photomultiplication for ultra-high external quantum efficiency of organic photodiodes
Authors: Kim Juhee , Kang Mingyun , Lee Sangjun , So Chan , Chung Dae Sung 
Published: January 2021

Abstract
A photomultiplication-type organic photodiode (PM-OPD), where an electric double layer (EDL) is strategically embedded, is demonstrated with an exceptionally high external quantum efficiency (EQE) of 2,210,000%, responsivity of 11,200 A W− 1, specific detectivity of 2.82 × 1014 Jones, and gain-bandwidth product of 1.92 × 107 Hz as well as high reproducibility. A metal-semiconductor Schottky interface consisting of an EDL enables the stabilization of trapped electron states within the acceptor domains of the photoactive layer by electrostatic interactions, boosting the PM-OPD gain generation. The effects of the EDL on the energetics of trapped electron states are confirmed by numerical simulations based on the drift-diffusion approximation of charge carriers. The feasibility of the fabricated high-EQE PM-OPD is demonstrated via a pixelated prototype image sensor. We believe that this new OPD platform opens up the possibility for the ultra-high-sensitivity organic image sensors, while maintaining the advantageous properties of organics.
Order–Disorder Transition of a Rigid Cage Cation Embedded in a Cubic Perovskite
Authors: Shi Zhifang , Fang Zheng , Wu Jingshu , Chen Yi , Mi Qixi 
Published: January 2021

Abstract
The structure and properties of organic–inorganic hybrid perovskites are impacted by the order–disorder transition, whose driving forces from the organic cation and the inorganic framework cannot easily be disentangled. Herein, we report the design, synthesis and properties of a cage-in-framework perovskite AthMn(N3)3, where Ath+ is an organic cation 4-azatricyclo[2.2.1.02,6]heptanium. Ath+ features a rigid and spheroidal profile, such that its molecular reorientation does not alter the cubic lattice symmetry of the Mn(N3)3− host framework. This pure order–disorder transition is well characterized by NMR, crystallography, and calorimetry, and associated with the realignment of Ath+ dipole from antiferroelectric to paraelectric. As a result, an abrupt rise in the dielectric constant was observed during the transition. Our work introduces a new family of perovskite structures and provides direct insights to the order–disorder transition of hybrid materials.
The effects of WeChat-based educational intervention in patients with ankylosing spondylitis: a randomized controlled trail
Authors: Song Yuqing , Xie Xia , Chen Yanlin , Wang Ying , Yang Hui , Nie Anliu , Chen Hong 
Published: January 2021

Abstract
Background: Ankylosing spondylitis(AS), as a common inflammatory rheumatic disease, often causes depression and impaired health-related quality of life(QoL). Although positive effects of patient education have been demonstrated, limited studies explored the benefits of education via mobile applications for AS patients. This study aimed to evaluate the effects of the WeChat-based educational intervention on depression, health-related QoL, and other clinical outcomes in AS patients.Methods: We conducted a single-blind randomized controlled trial from March to December 2017. Patients were recruited and randomized into the intervention group who received a 12-week WeChat-based educational intervention (consisting of four individual online educational sessions, online educational materials) or the control group receiving standard care. Data was collected at baseline and 12 weeks after the intervention. Outcomes were measured by Beck Depression Inventory-Ⅱ, the Medical Outcomes Study Short Form 36-item Health Survey, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Patient Global Score, visual analogue scales. Results: A total of 118 patients with AS were included and analyzed. Measures at baseline were comparable between groups. After the intervention, the intervention group reported significant higher scores of all domains of QoL except for physical function and validity, compared with the control group. Additionally, patients in the intervention group had lower depressive symptoms than the control group. No significant difference in other outcomes was observed at 12 weeks. Conclusions: This study found that the 12-week educational intervention via WeChat had positive effects on reducing depressive symptoms and improving health related QoL in Chinese patients with AS. We suggest that this intervention can be integrated into current routine care of AS patients.
Genetic Polymorphisms, LDL-C and sdLDL-C Help Optimize Coronary Heart Disease (CHD) Therapy
Authors: Dai Ruozhu , Zhuo Huilin , Wang Wei , Wang Xinjun , Zhao Xiaoyu 
Published: January 2021

Abstract
Background: Low-density lipoprotein cholesterol (LDL-C) and small, dense LDL-C (sdLDL-C) are important risk indicator of coronary heart disease (CHD), but their application in therapy monitoring of CHD is still far from being elucidated. Following the concept of precision medicine, we investigated whether the scientific medication based on medication-sensitive genes can reverse the LDL-C and sdLDL-C status in human bloodstream, so as to reveal the possibility of them as a monitoring indicator of CHD efficacy.Methods: A prospective study of CHD cohort containing 208 Chinese CHD patients (158 males and 50 females) and 20 healthy people (14 males and 6 females) was recruited. LDL-C and its subfractions were detected before and after treatment. Polymorphism of medication-sensitive genes, including SLCO1B1 (rs4149056, 521T>C), CYP2C19*2 (rs4244285, c.681G>A), and CYP2C19*3 (rs4986893, c.636G>A) were detected for medication guidance.Results: Nearly half of Chinese CHD patients (47.60%, 99/208) had genetic polymorphisms with homozygous or heterozygous mutations within these three genes. LDL-1 and LDL-2, subfractions of LDL-C, had a 100% positive rate in CHD patients and healthy people. However, sdLDL-C components of LDL-5 to LDL-7 were only enrichment in CHD patients. Moreover, the mean amount of sdLDL-C subfractions in CHD patients was significantly higher than that in healthy people. Among 180 patients with treatment remission, 81.67% (n=147) of CHD patients had decreased LDL-C, while 61.67% (n=111) of patients had decreased sdLDL-C.Conclusion: sdLDL-C has better accuracy on CHD screening than LDL-C, while LDL-C was more suitable for CHD therapy monitoring. Combined medication-sensitive genes polymorphism, LDL-C and sdLDL-C detection would optimize the treatment strategy for CHD patients.
Interacting With Virtual Objects via Embodied Avatar Hands Increases the Illusion of Presence, Increases Distraction, and Modulates VR Analgesia Effectiveness: A Randomized Crossover Trial.
Authors: Hoffman Hunter 
Published: January 2021

Abstract
The current study introduces a new experimental environment and apparatus for exploring cognitive factors in pain. Interacting with virtual objects via embodied avatar hands increased the illusion of “being there” in the virtual world, increased VR analgesia for acute pain, and reduced accuracy on an attention demanding task. Twenty-four healthy volunteer college students participated in this within-subject randomized crossover design study. During Phase 1, each participant received brief thermal pain stimuli during interactive embodied avatar VR vs. passive VR (no avatar and no interactivity), VR treatment order randomized. After each pain stimulus, participants provided subjective 0-10 ratings of pain. Compared to the passive VR condition, during the interactive avatar VR, participants reported significant reductions in 1). worst pain, 2). pain unpleasantness, 3). time thinking about pain and 4). they had significantly more fun during the pain stimulus (p = .000 for each). During Phase 2, participants performed a divided attention task in each VR condition. Participants made significantly more errors on the divided attention task during the interactive avatar VR condition, compared to passive VR, implicating an attention mechanism for how virtual reality reduces pain and helping understand how VR influences pain perception.
Correlation between SCAP Genetic Polymorphism and Coronary Artery Disease in a Han population in Xinjiang, China
Authors: He Xiao-Dong , Fu Zhen-Yan , Adi Dilare , Ma Yi-Tong , Wang Ying-Hong , Wang Yong-Tao , Abudesimu Asiya , Chen Bang-Dang , Liu Fen 
Published: January 2021

Abstract
SREBP cleavage-activating protein (SCAP) plays a vital role in the modulation of cholesterol homeostasis, and cholesterol dysregulation is tightly associated with coronary artery disease (CAD). To investigate the correlation of the genetic polymorphism of SCAP with CAD, we conducted a case-control study of 528 CAD patients (case group) and 483 age- and sex- matched subjects from whom CAD was excluded (control group). Three tagSNPs (rs147215799, rs17079634 and rs59586735) in SCAP gene were genotyped in all participants, the genotype and allele frequencies of which were compared between two groups to determine their associations with CAD. We found rs17079634 showed significant difference in genotype distribution between the case and control group (P=0.016). The difference was most prominent in a dominant model (TT vs. CT + CC, P=0.004). After adjustment for confounding factors, the difference remained statistically significant (OR =1.363, 95% confidence interval [CI]:1.022~1.818, P=0.035). Whereas no significant associations of the other two SNPs with CAD were observed (P=0.393 for rs147215799 and 0.303 for rs59586735, respectively）. We drew conclusion that the SCAP genetic polymorphism rs17079634 was associated with CAD.
Differential expression of microRNA-7188-5p and miR-7235 regulates Multiple Sclerosis in an experimental mouse model- an Biomarker approach
Authors: ibrahim hairul islam Mohamed , abdullah  , hanieh hamza , ahmed emad a , thirugnansambantham k 
Published: January 2021

Abstract
The short non-coding microRNAs (miRNAs), have emerged as reliable modulators of various pathological conditions including autoimmune diseases in mammals. The current study, aims to identify new potential differential expressed miRNAs and their downstream mRNA targets of the autoimmune disease, Multiple sclerosis (MS). First, we used a computational tool to identify a new set of miRNA(s) that are probably implicated in MS. Preliminary, computational screening reveals that miR-659-3p, miR-659-5p, miR- 684, miR-3607-3p, miR-3607-5p, miR-3682-3p, miR-3682-5p miR-4647, miR-7188-3p, miR-7188-5p and miR-7235 are specifically elevated in the secondary lymphoid cells of EAE mice. In addition, expression of the downstream target genes of these miRNAs such as FXBO33, SGMS-1, ZDHHC-9, GABRA-3, NRXN-2 were reciprocal to miRNA expression in lymphoid cells. These confirmed by applying the mimic and silencing miRNA models, these data suggesting new inflammatory target genes of these promising miRNA biomarkers. The in vivo adoptive transfer model revealed that the suppression of miRNA-7188-5p and miR-7235 changed the pattern of astrocytes and CNSpathophysiology. The current study identified set of miRNAs and their mRNA targets as reciprocal regulator in MS disease. The absence of miRNA-7188-5p and miR-7235 enhanced the disease alleviation. These optimized results highlight new set of miRNA’s based biomarkers with therapeutic potential in experimental MS.