bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genotype Analysis of ABCC1, NCF4 and CBR3 Polymorphism and the Association With Childhood Acute Lymphoblastic Leukemia in Mexican Childhood Population
Authors: Gándara-Mireles Jesús Alonso , Lares-Asseff Ismael , Reyes Espinoza Elio Aarón , Blanco Javier G. , Chairez Hernández Isaias , Córdova Hurtado Lourdes Patricia , Loera Castañeda Verónica , Patrón Romero Leslie , Venzor Sánchez Cristina , Payan Gándara Hugo , Arechiga Gurrola Dinora , Almanza Reyes Horacio 
Published: February 2021

Background: The identification of genetic risk factors for Acute Lymphoblastic Leukemia (ALL), are increasingly urgent and necessary.Objective: The purpose of this study is to determine the association of the genetic polymorphisms ABCC1 rs3743527, NCF4 rs1883112 and CBR3 rs1056892 with ALL.Methods: DNA samples were obtained in 71 children with ALL (from 2 to 18 years) and in 71 controls without ALL, to determine the polymorphisms by real-time polymerase chain reaction (qPCR), using specific TaqMan probes in a StepOne® thermal cycler (Applied Biosystems, United States).Results: The results of the Odds Ratio analysis show that in the rs1883112 polymorphism of the NCF4 gene, the heterozygous allele has a risk effect for ALL (OR = 3.1870, CI = 1.8880–7.9383 and p = 0.0002), in turn the mutated genotype (AA) is associated with a protective effect (OR = 0.26, 0.1248 to 0.5434 and p = 0.0003). On the other hand, the CBR3 rs1056892 polymorphism shows a significant association of risk to ALL, in the presence of the HT genotype (OR = 2.77, IC = 1.3837 to 5.5651 and p = 0.004) and the mutated genotype of this polymorphism has a significant association with protection to ALL in the HM genotype (OR = 0.52, IC = 0.2639 to 1.0304 and p = 0.05). While the inheritance models of the polymorphisms let us see that of the rs1883112 polymorphism of the NCF4 polymorphism; the HT genotype of the codominant model shows a protective effect against ALL (OR = 0.4117, IC = 0.1718 to 0.9866 and p = 0.04), the recessive model shows us and confirms what we already saw in table number 3, being that there is an association with protective effect in the HM genotype (OR = 0.2604, IC = 0.1248 to 0.5434 and p = 0.0003). In the polymorphism rs1056892 of the CBR3 gene, a protection association was found in the heterozygous allele of the codominant model (OR = 0.3448, IC = 0.1375 to 0.8896 and p = 0.0274). In addition, the recessive inheritance model for the HM genotype shows a protective effect to ALL, (OR = 0.52, CI = 0.9919 to 3.8638 and p = 0.05).Conclusion: There is an evident impact of the NCF4 rs1883112 and CBR3 rs1056892 polymorphisms with an increased risk of susceptibility to ALL; Likewise, through the codominant inheritance model, the effect of the variation of the CBR3 rs1056892 gene as a protective factor against ALL was evaluated.
In-game Social Interaction and Gaming Disorder: A Perspective From Online Social Capital
Authors: Heng Shupeng , Zhao Huanfang , Wang Minghui 
Published: February 2021

Background and Aims: Social interaction in the online games has been found to predict gaming disorder, but little research has examined the mechanism of this association. Drawing on the social capital theory, the present study investigated the mediating role of online social capital on the relationship between in-game social interaction and gaming disorder and the moderating role of alienation on the relationship between online social capital and gaming disorder.Methods: A sample of 457 Chinese massively multiplayer online role-playing game gamers was recruited to complete the In-game Social Interaction Questionnaire, Online Social Capital Scale, Alienation Scale, and Pathological Gaming Scale.Results: The results showed that online social capital was a mediator in the relationship between in-game social interaction and gaming disorder. Moreover, for individuals with low alienation, the effect of online social capital on gaming disorder was weaker than for those with high alienation.Conclusions: The present study provides new insight into the complex processes involved in the effect of in-game social interaction on gaming disorder, and the results have important theoretical and practical implications.
Development and Evaluation of a Therapist Training Program for Psilocybin Therapy for Treatment-Resistant Depression in Clinical Research
Authors: Tai Sara J. , Nielson Elizabeth M. , Lennard-Jones Molly , Johanna Ajantaival Riikka-Liisa , Winzer Rachel , Richards William A. , Reinholdt Frederick , Richards Brian D. , Gasser Peter , Malievskaia Ekaterina 
Published: February 2021

Introduction: Psychological support throughout psilocybin therapy is mandated by regulators as an essential part of ensuring participants' physical and psychological safety. There is an increased need for specially trained therapists who can provide high-quality care to participants in clinical studies. This paper describes the development and practical implementation of a therapist training program of psychological support within a current phase IIb international, multicenter, randomized controlled study of psilocybin therapy for people experiencing treatment-resistant depression.Description of Training Program: This new and manualized approach, based on current evidence-based psychotherapeutic approaches, was developed in partnership with different mental health researchers, practitioners, and experts; and has been approved by the FDA. Training consists of four components: an online learning platform; in-person training; applied clinical training; and ongoing individual mentoring and participation in webinars.This paper provides a brief overview of the method of support, the rationale and methodology of the training program, and describes each stage of training. The design and implementation of fidelity procedures are also outlined.Lessons Learned: As part of the phase IIb study of psilocybin therapy for treatment-resistant depression, 65 health care professionals have been fully trained as therapists and assisting therapists, across the US, Canada and Europe. Therapists provided informal feedback on the training program. Feedback indicates that the didactic and experiential interactive learning, delivered through a combination of online and in-person teaching, helped therapists build conceptual understanding and skill development in the therapeutic approach. Clinical training and engagement in participant care, under the guidance of experienced therapists, were considered the most beneficial and challenging aspects of the training.Conclusions: Clinical training for therapists is essential for ensuring consistently high-quality psilocybin therapy. Development of a rigorous, effective and scalable training methodology has been possible through a process of early, active and ongoing collaborations between mental health experts. To maximize impact and meet phase III and post-approval need, enhanced online learning and establishing pathways for clinical training are identified as critical points for quality assurance. This will require close public, academic and industry collaboration.
Geographical Variation of COPD Mortality and Related Risk Factors in Jiading District, Shanghai
Authors: Peng Qian , Zhang Na , Yu Hongjie , Shao Yueqin , Ji Ying , Jin Yaqing , Zhong Peisong , Zhang Yiying , Jiang Honglin , Li Chunlin , Shi Ying , Zheng Yingyan , Xiong Ying , Wang Zhengzhong , Jiang Feng , Chen Yue , Jiang Qingwu , Zhou Yibiao 
Published: February 2021

Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in China. Although numerous studies have been conducted to determine the risk factors for COPD mortality such as ambient air pollution, the results are not fully consistent.Methods: This study included mortality analysis and a case-control design by using the data extracted from the Mortality Registration System in Jiading District, Shanghai. Traditional logistic regression, geographically weighted logistic regression (GWLR), and spatial scan statistical analysis were performed to explore the geographic variation of COPD mortality and the possible influencing factors.Results: Traditional logistic regression showed that extreme lower temperature in the month prior to death, shorter distance to highway, lower GDP level were associated with increased COPD mortality. GWRL model further demonstrated obvious geographical discrepancies for the above associations. We additionally identified a significant cluster of low COPD mortality (OR = 0.36, P = 0.002) in the southwest region of Jiading District with a radius of 3.55 km by using the Bernoulli model. The geographical variation in age-standardized mortality rate for COPD in Jiading District was explained to a certain degree by these factors.Conclusion: The risk of COPD mortality in Jiading District showed obvious geographical variation, which were partially explained by the geographical variations in effects of the extreme low temperature in the month prior to death, residential proximity to highway, and GDP level.
Impact of Sarcopenia on Functional and Oncological Outcomes After Radical Prostatectomy
Authors: Angerer Markus , Salomon Georg , Beyersdorff Dirk , Fisch Margit , Graefen Markus , Rosenbaum Clemens M. 
Published: February 2021

Introduction and Objectives: Knowledge about the significance of sarcopenia (muscle loss) in prostate cancer (PCa) patients is limited. The aim of this study was to determine the influence of skeletal muscle index (SMI) on early functional and pathological outcome in patients undergoing radical prostatectomy (RP).Materials and Methods: One hundred randomly chosen patients who received RP between November 2016 and April 2017 at Martini-Klinik (Hamburg, Germany) were retrospectively assessed. SMI (skeletal muscle mass cross-sectional area at L3/m2) was measured by preoperative staging computed tomography scans at L3 level. Cox regression analysis was applied to determine the impact of SMI on post-operative outcome. Follow-up was 12 months. Continence was defined as no more than one safety pad per day.Results: Mean age of the cohort was 63.6 years. Mean SMI was 54.06 cm2/m2 (range, 40.65–74.58 cm2/m2). Of the patients, 41.4% had pT2, 28.7% had pT3a, and 29.9% had pT3b or pT4 PCa. SMI revealed to be without significant correlation on tumor stage. Follow-up data of 55 patients were available for early functional outcome analysis. SMI showed no significant influence on erectile function in multivariable Cox regression analysis. In multivariable Cox regression analysis, SMI turned out to have no influence on continence rates 6 weeks after surgery.Conclusion: The present study shows that patients undergoing RP have a wide range of SMI. Unlike in other urological malignancies, there was no significant impact of SMI on early functional outcome and pathological outcome. A larger cohort is needed to confirm these results.
Sağ Ventrikül Çıkış Yolu Darlıklarının Tamirinde Homogreft ve Contegra Greft Kullanılan Hastaların Sağ Kalımının Karşılaştırılması
Authors: AMANVERMEZ ŞENARSLAN Dilşad , ALAYUNT Emin Alp 
Published: February 2021

Giriş ve Amaç: Homogreftler veya ksenogreftler sağ ventrikül çıkış yolu (RVOT) darlıklarının tedavisinde günümüzde en sık kullanılan materyallerdir. Çalışmanın amacı RVOT tamirlerinde homogreft ve Contegra® Greft (ksenogreft) kullanılan hastaların mortalite oranlarını belirlemek ve sağ kalımlarını karşılaştırmaktır. Çalışmanın ikincil amacı ise mortalite için risk faktörlerinin belirlenmesidir.
Gereç ve Yöntemler: Çalışmaya üçüncü basamak sağlık kuruluşumuzda son yedi yılda RVOT darlığı nedeniyle homogreft veya Contegra® Greft kullanılarak RVOT rekonstrüksüyonu uygulanan hastalar dahil edilmiştir. Toplam 71 hastanın; 18’ine homogreft (%25,4) ve 53’üne (%74,6) ise Contegra® Greft ile RVOT rekonstrüksüyonu uygulanmıştır. Çalışma için yerel etik kurul izni alınmıştır.
Bulgular: RVOT darlığının en sık etiyolojik sebebi Fallot Tetralojisiydi. Contegra® Greft grubunun yaş ortalaması ve kullanılan greft çapları (t test, p
Effect of Soil and Fertilizer Treatment Systems on Agrochemical Properties of Fertility and Spring Wheat Yields
Authors: Носкова Е.В. 
Published: February 2021

Многолетний стационарный полевой опыт проводился на дерново-подзолистой среднесуглинистой почве в Ярославской области. В статье представлены результаты исследований по изучению действия разных по интенсивности систем обработки почвы и удобрений на изменение агрохимических показателей плодородия почвы и урожайности яровой пшеницы. Отмечена динамика накопления гумуса в пахотном слое почвы при системе поверхностно-отвальной обработки на 0,17%, совместном внесении соломы и полного минерального удобрения – на 0,15%. Выявлен рост рН при системе ежегодной отвальной обработки, системах без удобрений и одной соломы. Динамике повышения содержания фосфора на 57,00 мг/кг способствовало совместное применение соломы с полным минеральным удобрением. Увеличению содержания обменного калия содействовали: система энергосберегающей поверхностно-отвальной обработки (на 0,92 мг/кг) и система «солома + NРК» (на 44,09 мг/кг). Отмечено увеличение урожайности зерна яровой пшеницы (на 2,04 ц/га) при применении системы энергосберегающей поверхностно-отвальной обработки почвы. Совместное использование соломы с полным минеральным удобрением достоверно повысило урожайность на 8,18 ц/га. Для дерново-подзолистой среднесуглинистой почвы с временным избыточным увлажнением рекомендуется применение системы энергосберегающей поверхностно-отвальной обработки почвы и совместное внесение соломы с полным минеральным удобрением.
Long-term stationary field experiment was carried out on soddy podzolic middle loamy soil in the Yaroslavl region. The article presents the results of research on the effect of soil and fertilizer treatment systems different in intensity on changing agrochemical indicators of soil fertility and spring wheat yield. Dynamics of humus accumulation in arable layer of soil at system of surface and moldboard tillage by 0.17%, combined application of straw and complete minerals - by 0.15% was noted. An increase in pH was revealed with an annual moldboard tillage system, systems without fertilizers and straw. The dynamics of the increase in phosphorus content by 57.00 mg/kg were facilitated by the joint use of straw with complete minerals. The increase in the content of exchangeable potassium was facilitated by: an energy-saving surface and moldboard tillage (by 0.92 mg/kg) and a "straw + NPK" system (by 44.09 mg/kg). There was an increase in the yield of spring wheat grains (by 2.04 c/ha) when using an energy-saving surface and moldboard tillage system. The combined use of straw with complete minerals significantly increased yield by 8.18 c/ha. For soddy podzolic middle loamy soil with temporary excessive moistening it is recommended to use a system of energy-saving surface and moldboard tillage and joint application of straw with complete minerals.
Heat-Exchange Surface Calculation of Heat-Conducting Medium and Grain Trashed Heap
Authors: Николаев В.А. , Кряклина И.В. 
Published: February 2021

Для энергосбережения при сушке зерна в контактно-конвективной сушилке предлагается использовать тепло охлаждающей жидкости двигателя внутреннего сгорания. Жидкость поступает в трубки контактно-конвективной сушилки. Трубки теплоносителя расположены наклонно под углом 40° параллельно друг другу по всей ширине сушилки. Над ними, в шахматном порядке – паросборники. Над паросборниками установлен плавающий разравнивающий транспортёр, который изменяет своё положение в зависимости от объёма зерна в контактно-конвективной сушилке. Рассмотрена отдельная зерновка, движущаяся по поверхности трубки теплоносителя. В результате нагрева зерновки происходит её отпотевание – появление влаги на поверхности зерновки. Произведён теплотехнический расчёт поверхности теплообмена теплоносителя и зернового вороха, определено количество тепла, передающегося зерновому вороху в результате контактного теплообмена. Установлено, что использование тепла охлаждающей жидкости двигателя внутреннего сгорания в контактно-конвективной сушилке приводит к энергосбережению при сушке зерна.
For energy saving at grain drying in contact-convection drier it is proposed to use heat of cooling liquid of internal combustion engine. The liquid enters the tubes of the contact-convection drier. Heat carrier tubes are set at an angle of 40 ° parallel to each other along the full width of the drier. There are steam headers staggering above them. An amphibious leveling carrier is installed above the steam headers which changes its position depending on the volume of grain in the contact-convection drier. Separate caryopsis moving along surface of heat-conducting medium tube is considered. As a result of the heating of the caryopsis its sweating occurs – the appearance of moisture on the surface of the caryopsis. Thermotechnical calculation of heat-exchange surface of heat-conducting medium and grain trashed heap is performed, amount of heat transferred to grain trashed heap as a result of contact heat exchange is determined. It has been found that using the cooling liquid heat of the internal combustion engine in the contact-convection drier leads to energy saving when drying grain.
Influence research of an α–form alumina type on the properties of samples from vibrocasting mullite corundum granular masses
Authors: Martynenko V. V. , Kushchenko P. A. , Shulyk I. G. , Kushchenko K. I. , Krakhmal Yu. O. , Tkachenko L. P. 
Published: February 2021

The technology of refractories vibrocasting was developed by JSC "URIR named after A. S. Berezhnoy" in particular highly refractory mullite corundum crucibles for melting of heat-resistant alloys in induction furnaces. At manufacturing of highly refractory vibrocasting mullite corundum refractories a-form alumina, as a dispersion binder, which milling to a particles size of less than 10 μm (the content of particles less than 4 μm in such alumina is more than 50 %) is used. For improvement the casting characteristics of vibrocasting masses dispersants are used. At research milling kinetics alumina of all brands was milling in a vibration mill for a specified time. For this research a certain amount of the investigated alumina of each brand was loaded into a vibration mill, and after a specified grinding time (30, 45, 60, 75 and 90 min), a sample of alumina after milling was taken in a specified amount. In this work, the kinetics of changes the dispersion of alumina (S, N and NR brands) during their milling was studied. The dispersion of alumina which were needed (the content of particles less than < 10 μm in such alumina is not less than 90 %, the content of particles less than < 4 μm — not less than 50 %) was achieved in almost the same milling time was found (~ 45 min). With a further increase of milling time to 60, 75 and 90 minutes, the dispersion of alumina N and NR brands increases in comparison with alumina S brand and after 90 minutes of milling, the content of particles < 4 μm in alumina, respectively, is ~ 60, ~ 75 and ~ 80 %. After fired at a temperature of 1580 °C the properties of vibrocasting mullite corundum samples, which contain alumina S, N and NR brands, are characterized by a high level of apparent density (above 3 g/cm3), open porosity (less than 16 %) and cold crushing strength (above 140 N/mm2). The high properties make it possible to use a-form alumina N and NR brands along a-form alumina S brand in the technology of vibrocasting mullite corundum refractories, including the highly refractory mullite corundum crucibles.
The Effects of Leaderships Styles, Work-Life Balance, and Employee Engagement on Employee Performance
Authors: Katili Putiri Bhuana , Wibowo W. , Akbar Maruf 
Published: February 2021

Employee Engagement is an important strategy on increasing company performance. The aims of this research is to elaborate influences of leadership styles and work- life balance to the employee engagement; also influence of employee engagement to the employee performance. To achieve this aim, the data was collected from 204 employees using questionnaire as instrument of research. The collected data was analyzed using SPSS and Structural Equation Modeling. This research conducted in steel industry. From this research can be concluded that work-life balance have most significant influence to employee engagement, and employee engagement have strong influence to the employee performance. By increasing leadership styles and work-life balance , the company could improve employee engagement. Therefore, the company management can utilize this research result for increasing employee performance and company competition.
DPM Dua Mode Dilengkapi Thermohygrometer dan Pemilihan Tekanan (Positive Pressure)
Authors: Kusumadewi Ketut Dyah , Syaifudin Syaifudin , Indrato Tri Bowo 
Published: February 2021

Kalibrasi merupakan suatu kegiatan teknis yang terdiri atas penetapan, penentuan suatu atau lebih sifat dan karakteristik dari suatu produk, proses atau jasa sesuai dengan prosedur khusus yang telah ditetapkan. Digital Pressure Meter (DPM) merupakan alat yang digunakan untuk mengukur tekanan positif dan negatif pada alat Kesehatan. Tujuan dibuatnya alat Digital Pressure Meter (DPM) Dua Mode dilengkapi Thermohygrometer dan Pemilihan Tekanan (Positive Pressure) sebagai solusi untuk menciptakan perangkat pemantauan tekanan darah yang lebih informatif efektif serta akurat dalam pengukurannya. Kontribusi penelitian ini adalah sistem dapat dijalankan dengan menggunakan sensor tekanan tiup, hasil ukur bisa dikonversi kesatuan kPa dan ditampilkan di LCD TFT Nextion 2,4 inch. Agar sistem berjalan maka diperlukan tekanan tiup yang sesuai dengan alat tensimeter itu sendiri. Menggunakan sensor MPX 5050GP sebagai sensor tekanan positif. Membutuhkan tekanan maksimal 300 mmHg. Menggunakan sensor DHT 22 untuk suhu kelembaban. Alat ini juga di lengkapi degan timer uji kebocoran. Display yang digunakan pada modul ini adalah LCD TFT Nextion 2,4 inch Setelah melakukan proses pengukuran ke alat tensimeter air raksa sebanyak 6 kali didapatkanhasilterkecil 0 mmHg pada tekanan 0 mmHg dan yang terbesar 298.0 mmHg pada tekanan 300mmHg. Simpangan rata-rata terbesar ini dikarenakan adanya kebocoran tekanan antara selang penghubung output modul dan penghubung ke alat tensimeter. Berdasarkan pengambilan data suhu kelembaban yang dilakukan pada ruangan diperoleh 31̊C pada suhu dan 87% pada kelembaban. Dari penelitian ini Rangkaian keseluruhan yang dibuat sudah sesuai dengan kebutuhan modul DPM Hasil penelitian menunjukkan bahwa modul bisa digunakan untuk proses kalibrasi pada alat tensimeter.
Análise exploratória de dados espaciais da produção de café no estado do Paraná, 1980-2018
Authors: Pompermayer Sesso Patricia , Pereira Luiz Filipe Protásio , Sesso Filho Umberto Antonio , Zapparoli Irene Domenes 
Published: February 2021

O objetivo deste estudo foi realizar a análise exploratória dos dados espaciais (Aede) da produção de café dos municípios do estado do Paraná, no período 1980-2018. A fonte dos dados foi o Instituto Paranaense de Desenvolvimento Econômico e Social (Ipardes). Nesse período, a produtividade da cultura do café no estado do Paraná aumentou de cerca de 900 para 1.500 kg ha-1, com tendência de crescimento de 16,48 kg ha-1 por ano. A introdução de novas tecnologias na década de 1990 propiciou menor risco aos produtores, e o aumento da produtividade implicou a redução do custo médio da saca de café e o aumento da competitividade. No período de análise, ocorreu o deslocamento da maior parte da área colhida e da produção para as Mesorregiões Norte Pioneiro e Norte Central, que passaram a concentrar a produção e os municípios mais produtivos. Verificou-se uma autocorrelação espacial da produtividade dos municípios, e identificaram-se agrupamentos espaciais Alto-Alto dos municípios localizados, principalmente, nas Mesorregiões Norte Pioneiro e Norte Central do estado do Paraná, no ano de 2018.