bluuebunny/crossref_metadata_2025_split huggingface dataset:
GANG SEBAGAI PUSAT NILAI LOKALITAS KEHIDUPAN MASYARAKAT KAMPUNG KOTA
Authors: Chandra Herson J. , Sunaryo Rony G. 
Published: April 2021

Title: Alley as the Center/ Generator of Locality Values of the Community Life in Urban Kampong
The people in the urban kampong as part of settlement area with rather high intensity tend to maximize their property. The community along with their value system build and develop spaces following their particular meaning. Through this research the spaces as the embodiment of the local life in physical form in Kampong Keputran would be observed and aimed to find the meaning of it. This study will use Regionalism of Indonesia Architecture as one of the approach to find the local values that lives in the kampong, and Spatial Recoqnition as an operational theory applied to study and to get the community understanding about values perceived in this settlement area. This study would be a library research using data as documentation drawings of the existing condition, and also research journal as supportive information. The result of this research would be finding on the most dominant spaces that influencing the quality of social life in kampong. This result could be used as a design criteria for a multi story housing that accomodating the local values of urban kampong community. And hopefully there will be more understanding about how the community give meaning to the space in the kampung as their living space.
IDENTIFIKASI KELAYAKAN RUANG SEMPADAN REL DI MEJING DAN SEDAYU, YOGYAKARTA SEBAGAI RUANG PUBLIK
Authors: Dani Adinda Rafika 
Published: April 2021

Title: Feasibility Identification of the Railway Track Setback in Mejing and Sedayu, Yogyakarta for a Public Space
The availability of public space in an urban area/city is very important. Apart from functioning as regional landmarks, open spaces also function as areas for community interaction. This study aims to identify the feasibility of the lost space area along the railroad boundaries in Mejing and Sedayu as a public space. The research method used is to conduct surveys and interviews with people who use these two railway track border spaces. The survey variables used are comfort, relaxation, passive engagement, active engagement and discovery. The results of the study found that the public space on the Mejing railway track border, from the point of view of comfort, received a poor rating with a percentage of 47.62%, while in Sedayu it received almost the same rating, which was not good with a percentage of 43.14%. When viewed from the relaxation indicator, the open space on the border of Mejing and Sedayu rails received a good rating with a percentage of 52.53% and 52.67%. Meanwhile, the level of open space security at the Mejing railway track border stated that the assessment was good with an average percentage of 53.17% and at the Sedayu rail border received a poor rating with a percentage value of 42.17%. The factor of the low feasibility of open space at the railroad border is a lack of facilities, cleanliness, parking management and the comfort of open space users.
SENTUHAN ARSITEKTUR NUSANTARA PADA ILMU KONSTRUKSI BANGUNAN, STRATEGI MENINGKATKAN KUALITAS PENGAJARAN SECARA DARING
Authors: Koesmartadi Ch. , Anandhita Gustav 
Published: April 2021

Title: A Nusantara Architecture Touch on Building Construction Science: A Strategy to Improve Quality for Online Teaching
Covid-19 pandemic hit the world hard, causing so many pedagogical reconfiguration and alteration that forces the world of education to change its approach, particularly in the applied science of architectural. This shift seems to be positive in terms of time available to rediscover and realign its relevance towards local wisdom. Visual communication during online class appears to be more interesting due to its capability to showcasing appealing sketch on PC/laptop or smartphone. This situation gives teacher and lecturer even greater chance to accommodate in-depth local construction materials. In order to achieve better formula, innovation are needed to boost visual appeal. By using online devices, students are capable of capitalizing features which ensure their understanding and focus through 3-D structures and visualization, especially towards roof that has been an instrumental character of Nusantara Architecture.
Disorders of sexual function in postmenopausal patients
Authors: Khashukoeva A. Z. , Burdenko M. V. , Overko A. V. , Ryzhova T. E. , Safonina M. S. 
Published: April 2021

Introduction.Research in recent years has shown that sexual dysfunction is now common in post-menopausal women and that it has a significant impact on their quality of life.Aim:to identify the major causes of sexual dysfunction in postmenopausal women and their treatment options, by analysing different literature sources.Materials and methods. During the study of this problem, 25 sources of literature, both Russian and foreign, dating from 2007 to 2020 were analysed.Results and discussion. The main etiological aspects of sexual dysfunction in postmenopausal women, such as disorders of sexual desire, sexual pain disorders, orgasmic disorders are considered in this article. The role of physiological processes occurring in a woman’s organism during this age period in the formation of sexual dysfunction is presented, namely, the influence of insufficiency of sex hormones (In particular, estrogens) and genitourinary syndrome on disorders of the sexual sphere.The main methods of treatment are described, including hormone replacement therapy, the use of non-invasive laser technology, and surgical correction of the dysfunction and atrophy of the pelvic floor muscles. Particular attention is paid to the use of the synthetic steroid tibolone and flibanserin, a drug used to treat hypoactive sexual desire disorder, and the data concerning their high efficacy are presented.Conclusions.The predominant manifestation of sexual dysfunction are disorders of sexual desire and sexual pain disorders. Thus it is important to pay attention to this problem and to treat sexual dysfunction by treating its causes.Conclusion.The treatment of sexual dysfunction must address the causes. In many cases, psychotherapy is necessary. MHT has a positive effect on the sexual function of patients. Testosterone therapy is justified in this case, but is rarely used, as it has a number of side effects and contraindications. Synthetic steroids (Tibolone) have shown good results in the treatment of sexual dysfunction.
Corifollitropin alfa in different variants of ovarian response in assisted reproductive technology programmes: literature review
Authors: Syrkasheva A. G. , Ermakova D. M. 
Published: April 2021

This literature review focuses on the use of corifollitropin alfa for ovarian stimulation in assisted reproductive technology (ART) programmes in different groups of patients. Corifollitropin alfa is a gonadotropin drug with prolonged FSH activity. The main difference between corifollitropin alfa and other gonadotropins is the higher level of peak FSH, which leads to the recruitment of more follicles. Another feature is the inability to adjust the gonadotropin dose during the first days of ovarian stimulation. In contrast to traditional indications/contraindications for gonadotropins, the use of cortifollitropin is not recommended in combination with GnRH agonists or in patients with polycystic ovary syndrome.Evidence for the feasibility and efficacy of using corifollitropin alfa in patients with various ovarian response variants in ART programmes has been analysed. Most researchers agree that the use of corifollitropin alfa can be recommended for patients with a presumed poor or normal ovarian response. The use of corifollitropin alfa in patients with a presumed excessive response to ovarian timulation is possible when embryo transfer is not expected: in oocyte donation/oocyte vitrification cycles or in "freeze-all" cycles.A significant advantage of using corifollitropin alfa for oocyte donor patients is the single administration of the drug, which can be done in a medical facility, which reduces the risk of prescription non-compliance.The use of corifollitropin alfa in protocols with GnRH agonists requires further research: firstly, corifollitropin alfa has no LH component and secondly, there is no possibility of ovulation trigger replacement in this protocol if there is a high risk of early ovarian hyperstimulation syndrome.
Nutritional support in pregnancy: possibilities for the prevention of obstetric complications
Authors: Mikhailova O. I. , Mirzabekova D. D. , Kan N. E. , Tyutyunnik V. L. 
Published: April 2021

This review focuses on the causes and consequences of nutritional deficiencies in the pregnant woman’s diet, as well as on the possibilities of its supplementation. It has been shown that inadequate intake of vitamins and minerals during pregnancy is accompanied by a lack of nutrient supply to the fetus, which can cause growth retardation, low birth weight and other obstetric and perinatal complications.According to the analysed guidelines and recommendations, the body’s need for vitamins and minerals increases at least twice as much during pregnancy. Adverse effects of the environment, a number of gastrointestinal and liver diseases, chronic diseases, antibiotic therapy, etc. increase this need.However, adequate nutritional support of the fetus is the result of several steps. These include the frequency of maternal food intake, the availability of nutrients in the food and the ability of the placenta to transport substrates effectively to the fetus.The most recommended vitamin for consumption in pregnancy is folic acid, alone or in combination with other B vitamins, as its deficiency leads to birth defects in the child.The authors of this review have reviewed a number of large studies conducted over the past decade that recommend iron and folic acid for pregnant women, regardless of dietary intake, as they have proven beneficial effects on the course and outcome of pregnancy. Folic acid, according to current recommendations, must be prescribed to every pregnant woman in the form of 400 mcg tablets daily regardless of her diet. Other most important and necessary vitamins for pregnant women are: vitamins A, C, D, E, K, B1, B2, B6, B12, PP, pantothenic acid, biotin.
Educação no Contexto Amazônico: Capacidades, Relações Intraorganizacionais e os Reflexos na Gestão Educacional
Authors: Silva Lucas Pereira da , Rodrigues Ritiele de Jesus , Silva Paula Carla Raiana , Ribeiro Raykele Sena , Santos Marco Aurélio dos , Almeida Léo César Parente de 
Published: April 2021

O presente estudo visa analisar as relações intraorganizacionais de uma organização pública do contexto amazônico. Para tanto, realizou-se entrevistas com diferentes atores para subsidiar as discussões. As entrevistas foram analisadas seguindo os princípios da Análise de Conteúdo. Os resultados mostraram que o capital humano, as crenças, o relacionamento, o designer organizacional entre outros impactam na coordenação e no desempenho das ações organizacionais. Constata-se que para mitigar os fatores negativos são necessárias mudanças no sistema de coordenação, no delineamento organizacional, na estrutura de autoridade, de responsabilidade e de especialização dos atores internos.
Insights into the Dynamic Fluctuations of the Protein HPV16 E1 and Identification of Motifs by Using Elastic Network Modeling
Authors: Malik Rabbiah , Fazal Sahar 
Published: April 2021

Background:
Cancers of cervix, head and neck regions have been found to be associated
with Human Papilloma Virus (HPV) infection. E1 protein makes an important papillomavirus replication
factor. Among the ORFs of papillomaviruses, the most conserved sequence is that of the
E1 ORF. It is the viral helicase with being a member of class of ATPases associated with diverse
cellular activities (AAA+) helicases. The interactions of E1 with human DNA and proteins occurs
in the presence of short linear peptide motifs on E1 identical to those on human proteins.

Methods:
Different Motifs were identified on HPV16 E1 by using ELMs. Elastic network models
were generated by using 3D structures of E1. Their dynamic fluctuations were analyzed on the basis
of B factors, correlation analysis and deformation energies.

Results:
3 motifs were identified on E1 which can interact with Cdk and Cyclin domains of human
proteins. 11 motifs identified on E1 have their CDs of Pkinase on human proteins. LIG_MYND_2
has been identified as involved in stabilizing interaction of E1 with Hsp40 and Hsp70. These motifs
and amino acids comprising these motifs play a major role in maintaining interactions with human
proteins, ultimately causing infections leading to cancers.

Conclusion:
Our study identified various motifs on E1 which interact with specific counter domains
found in human proteins, already reported having the interactions with E1. We also validated
the involvement of these specific motifs containing regions of E1 by modeling elastic networks
of E1. These motif involving interactions could be used as drug targets.
Evaluation of Benzamide-Chalcone Derivatives as EGFR/CDK2 Inhibitor: Synthesis,
In-Vitro Inhibition, and Molecular Modeling Studies
Authors: Joshi Akshada , Bhojwani Heena , Wagal Ojas , Begwani Khushboo , Joshi Urmila , Sathaye Sadhana , Kanchan Divya 
Published: April 2021

Background:
EGFR (Epidermal Growth Factor Receptor) and CDK2 (Cyclin Dependent Kinase 2)
are important targets in the treatment of many solid tumors and different ligands of these receptors share many
common structural features.

Objective:
The study involved the synthesis of benzamide-substituted chalcones and determination of their
antiproliferative activity as well as a preliminary evaluation of EGFR and CDK2 inhibitory potential using both
receptor binding and computational methods.

Methods:
We synthesized 13 benzamide-substituted chalcone derivatives and tested their antiproliferative
activity against MCF-7, HT-29 and U373MG cell lines using Sulforhodamine B Assay. Four compounds were
examined for activity against EGFR and CDK2 kinase. The compounds were docked into both EGFR and CDK2
using Glide software. The stability of the interactions for the most active compound was evaluated by Molecular
Dynamics Simulation using Desmond software. Molecular docking studies on mutant EGFR (T790M,
T790M/L858R, and T790M/C797S) were also carried out.

Results:
From the SRB assay, we concluded that compounds 1g, and 1k were effective in inhibiting the growth of
the MCF-7 cell line whereas the other compounds were moderately active. Most compounds were either moderately
active or inactive on U373 MG and HT-29 cell lines. Compounds 1g and 1k showed good inhibitory activity against
CDK2 kinase while 1d and 1f were moderately active. Compounds 1d, 1f, 1g, and 1k were moderately active
against EGFR kinase. Molecular docking reveals the involvement of one hydrogen bond with Met793 in binding
with EGFR; however, it was not stable during the simulation and these compounds bind to the receptor mainly via
hydrophobic contacts. This fact also points towards a different orientation of the inhibitor within the active site of
EGFR kinase. Binding mode analysis for CDK2 inhibition studies indicates that hydrogen bonding interactions with
Lys 33 and Leu83 are important for the activity. These interactions were found to be stable throughout the
simulation. Considering the results for wild-type EGFR inhibition, the docking studies on mutants were performed
and which indicate that the compounds bind to the mutant EGFR but the amino acid residues involved are similar to
the wild-type EGFR, and therefore, the selectivity seems to be limited.

Conclusion:
These benzamide-substituted chalcone derivatives will be useful as lead molecules for the further
development of newer inhibitors of EGFR and/or CDK2 kinases.
Interaction between the Local and General Zone for the Post-tensioned Girder Anchorage Zone
Authors: Werdina Ghassan M. , Aziz Omar Q. 
Published: April 2021

Background:
The use of post-tensioning in girders causes high bearing and compressive stresses in the anchorage zone. In this study, the behavior of the anchorage zone and the interaction between the local and general zone are investigated. The variables included different reinforcements for both the local and general zones for a block of two anchorage devices.

Methods:
Both experimental and numerical methods have been applied to study the behavior of the anchorage zone. The experimental part of the study involved laboratory testing of sixteen specimens, and the numerical study was conducted using ABAQUS non-linear finite element analysis.

Results:
Tie reinforcement provided additional confinement for the local zone, and this confinement was more for the specimens with originally less confined spiral reinforcement strength. There was a slight or no effect of the local zone reinforcement on the general zone strength and ultimate load of the anchorage zone when the failure was in the general zone.

Conclusion:
Confinement of the local zone prevented the brittle bearing and compression failure of this zone.
Geographic Distribution of the Prevalence of Neurocysticercosis in the Municipality of Piedade, São Paulo
Authors: Camargo José Augusto , Gianini Reinaldo José 
Published: April 2021

Background:
Neurocysticercosis is a globally occurring parasitosis that affects the central nervous system. The main clinical manifestation is seizures.The aim of this study was to analyze the geographic distribution of patients with seizures attending the Emergency Unit of the Piedade municipality, SP, with a diagnosis of neurocysticercosis, and to compare the association of its prevalence with age, basic sanitation and food hygiene habits between rural and urban areas.

Methods:
One hundred thirty-six patients with seizures were evaluated. The Epidemiological data of all subjects will be described.

Results:
The diagnosis of neurocysticercosis was confirmed in 24 patients, corresponding to a prevalence of 17.65%. The presence of an open sewer predominated in the rural area, while the consumption of unwashed fruits, presence of elderly people and geographic distribution were similar in the two areas.

Conclusions:
Urgent measures to raise awareness about the disease and preventive actions should be taken by world authorities.
Challenges With Developing Secure Mobile Health Applications: Systematic Review
Authors: Aljedaani Bakheet , Babar M Ali 
Published: April 2021

BackgroundMobile health (mHealth) apps have gained significant popularity over the last few years due to their tremendous benefits, such as lowering health care costs and increasing patient awareness. However, the sensitivity of health care data makes the security of mHealth apps a serious concern. Poor security practices and lack of security knowledge on the developers’ side can cause several vulnerabilities in mHealth apps.ObjectiveIn this review paper, we aimed to identify and analyze the reported challenges concerning security that developers of mHealth apps face. Additionally, our study aimed to develop a conceptual framework with the challenges for developing secure apps faced by mHealth app development organizations. The knowledge of such challenges can help to reduce the risk of developing insecure mHealth apps.MethodsWe followed the systematic literature review method for this review. We selected studies that were published between January 2008 and October 2020 since the major app stores launched in 2008. We selected 32 primary studies using predefined criteria and used a thematic analysis method for analyzing the extracted data.ResultsOf the 1867 articles obtained, 32 were included in this review based on the predefined criteria. We identified 9 challenges that can affect the development of secure mHealth apps. These challenges include lack of security guidelines and regulations for developing secure mHealth apps (20/32, 63%), developers’ lack of knowledge and expertise for secure mHealth app development (18/32, 56%), lack of stakeholders’ involvement during mHealth app development (6/32, 19%), no/little developer attention towards the security of mHealth apps (5/32, 16%), lack of resources for developing a secure mHealth app (4/32, 13%), project constraints during the mHealth app development process (4/32, 13%), lack of security testing during mHealth app development (4/32, 13%), developers’ lack of motivation and ethical considerations (3/32, 9%), and lack of security experts’ engagement during mHealth app development (2/32, 6%). Based on our analysis, we have presented a conceptual framework that highlights the correlation between the identified challenges.ConclusionsWhile mHealth app development organizations might overlook security, we conclude that our findings can help them to identify the weaknesses and improve their security practices. Similarly, mHealth app developers can identify the challenges they face to develop mHealth apps that do not pose security risks for users. Our review is a step towards providing insights into the development of secure mHealth apps. Our proposed conceptual framework can act as a practice guideline for practitioners to enhance secure mHealth app development.
Effectiveness of Virtual Reality Interventions for Adolescent Patients in Hospital Settings: Systematic Review
Authors: Ridout Brad , Kelson Joshua , Campbell Andrew , Steinbeck Kate 
Published: April 2021

Background
Given the high level of interest and increasing familiarity with virtual reality among adolescents, there is great potential to use virtual reality to address adolescents’ unique health care delivery needs while in hospital. While there have been reviews on the use of virtual reality for specific health conditions and procedures, none to date have reviewed the full scope of virtual reality hospital interventions for adolescents who are often combined with children as a homogenous group, despite the fact that adolescents experience virtual environments different from children.

Objective
The aim of this review was to systematically identify available evidence regarding the use of virtual reality interventions for adolescent patients in hospital settings to evaluate effectiveness, suitability, and safety and identify opportunities for future research.

Methods
PubMed, PsycINFO, Medline, and Scopus databases were searched using keywords and phrases. Retrieved abstracts (n=1525) were double screened, yielding 276 articles for full-text screening. Of these, 8 articles met inclusion criteria. Data were extracted to a standardized coding sheet, and a narrative synthesis was performed due to the heterogeneity of the studies.

Results
Four RCTs and 4 single-case reports were identified for inclusion, all of which aimed to reduce pain or anxiety. The scenarios targeted were burn pain, venipuncture, chemotherapy, preoperative anxiety, and palliative care. Three out of 4 RCTs found significant reductions in pain or anxiety outcomes measures when using virtual reality compared to standard care or other distraction techniques; however, only 1 study combined self-reported experiences of pain or anxiety with any physiological measures. Single-case reports relied primarily upon qualitative feedback, with patients reporting reduced pain or anxiety and a preference for virtual reality to no virtual reality.

Conclusions
Virtual reality can provide a safe and engaging way to reduce pain and anxiety in adolescents while in hospital, particularly when virtual reality software is highly immersive and specifically designed for therapeutic purposes. As VR becomes more accessible and affordable for use in hospitals, larger and more diverse studies that capitalize on adolescents’ interest in and aptitude for virtual reality, and on the full range of capabilities of this emerging technology, are needed to build on these promising results.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42020198760; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020198760