bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with the progression of gastric intestinal metaplasia: a multicenter, prospective cohort study
Authors: Mommersteeg M. C. , Eikenboom E. L. , Nieuwenburg S. A. V. , Yu B. , den Hollander W. J. , Holster I. Lisanne , den Hoed Caroline M. , Capelle L. G , Tang Thjon J. , Anten Marie-Paule , Prytz-Berset I. , Witteman E. M. , ter Borg F. , Burger Jordy P. W. , Bruno Marco J. , Fuhler G. M. , Peppelenbosch Maikel P. , Doukas Michael , Kuipers Ernst J. , Spaander Manon C.W. 
Published: February 2021

Abstract
Background and study aims Gastric cancer (GC) is usually preceded by premalignant gastric lesions (GPLs) such as gastric intestinal metaplasia (GIM). Information on risk factors associated with neoplastic progression of GIM are scarce. This study aimed to identify predictors for progression of GIM in areas with low GC incidence.
Patients and methods The Progression and Regression of Precancerous Gastric Lesions (PROREGAL) study includes patients with GPL. Patients underwent at least two upper endoscopies with random biopsy sampling. Progression of GIM means an increase in severity according to OLGIM (operative link on gastric intestinal metaplasia) during follow-up (FU). Family history and lifestyle factors were determined through questionnaires. Serum Helicobacter pylori infection, pepsinogens (PG), gastrin-17 and GC-associated single nucleotide polymorphisms (SNPs) were determined. Cox regression was performed for risk analysis and a chi-squared test for analysis of single nucleotide polymorphisms.
Results Three hundred and eight patients (median age at inclusion 61 years, interquartile range (IQR: 17; male 48.4 %; median FU 48 months, IQR: 24) were included. During FU, 116 patients (37.7 %) showed progression of IM and six patients (1.9 %) developed high-grade dysplasia or GC. The minor allele (C) on TLR4 (rs11536889) was inversely associated with progression of GIM (OR 0.6; 95 %CI 0.4–1.0). Family history (HR 1.5; 95 %CI 0.9–2.4) and smoking (HR 1.6; 95 %CI 0.9–2.7) showed trends towards progression of GIM. Alcohol use, body mass index, history of H. pylori infection, and serological markers were not associated with progression.
Conclusions Family history and smoking appear to be related to an increased risk of GIM progression in low GC incidence countries. TLR4 (rs11536889) showed a significant inverse association, suggesting that genetic information may play a role in GIM progression.
Radiofrequency vapor ablation for Barrett’s esophagus: feasibility, safety and proof of concept in a stepwise study with in vitro, animal, and the first in-human application
Authors: van Munster Sanne N. , Pouw Roos E. , Sharma Virender K. , Meijer Sybren L. , Weusten Bas L. A. M. , Bergman Jacques J. G. H. M. 
Published: February 2021

Abstract
Introduction The Radiofrequency Vapor Ablation (RFVA) System (AquaMedical, Inc., Santa Ana, CA) is a novel ablation system for eradication of Barrett’s esophagus, that generates vapor at 100 °C using an RF electrode located in the catheter tip. We performed in-vitro dosimetry studies and the first in-human feasibility study.
Methods The system includes an RFVA generator with syringe pump and a through-the-scope-catheter. The RFVA system was tested in-vitro (lean-beef and porcine study) and ablation depth was compared to focal RFA. Two doses were selected for further in-vivo testing in dysplatic BE patients. Repeat endoscopy with histology was performed after 8 weeks to assess squamous conversion.
Results In porcine, RFVA 3-seconds was comparable to RFA, whereas RFVA 5-seconds produced slightly deeper ablation. We selected a conservative 1-second and 3-seconds for human study. Fifty-three ablations were successfully applied in 15 patients with no adverse events. Follow-up endoscopy showed a median squamous conversion of 55 % (IQR 33 – 74) and 98 % (56 – 99) for 1 and 3-seconds, respectively.
Conclusions In this 3-phase study with lean-beef, porcine and the first in-human application, the RFVA system was feasible for esophageal ablation and successfully and safely converted targeted BE areas into squamous epithelium.
Endoscopic retrograde cholangiopancreatography in infants and children
Authors: Åvitsland Tone Lise , Aabakken Lars 
Published: February 2021

Abstract
Background and study aims Previous reports have suggested that endoscopic retrograde cholangiopancreatography (ERCP) in pediatric patients are safe. However, the total number of cases presented in the literature remains small. We present results regarding safety and outcomes in pediatric patients undergoing ERCP at Oslo University Hospital.
Patients and methods Patients < 18 years who underwent ERCP between April 1999 and November 2017 were identified using procedure codes. Medical records were examined for age, gender, diagnosis, indications, type of sedation, findings, interventions, and complications.
Results A total of 244 procedures were performed in 158 patients. Fifty-six of these were in 53 infants (age ≤ 1 year). Mean age was 8.8 years. The youngest patient was 8 days old. Mean weight was 5.0 kg in infants, the smallest weighing 2.9 kg. Cannulation failed in 19 (7.8 %). The main indication in infants was suspicion of biliary atresia (n = 38). Six of the procedures (10.7 %) were therapeutic. In children the main indications were biliary stricture (n = 64) and investigation of primary sclerosing cholangitis (PSC) (n = 45). 119 (63.2 %) of these procedures were therapeutic.Complications were uncommon in infants; only two episodes of infection were registered. In children (> 1 year) post-ERCP pancreatitis were seen in 10.4 %.
Conclusions Our retrospective series of ERCP procedures includes 56 procedures in infants, which is one of the largest series presented. Complications in infants are rare and post-ERCP pancreatitis was not seen. In older children 10.4 % experienced post-ERCP pancreatitis. In expert hands, ERCP was shown to be acceptably feasible and safe in infants and children.
Prospective Audit of Gentamicin Drug Monitoring Practice in a Pediatric Cancer Center
Authors: Herberger Sarah , Oberkircher Nadine , Wenzel Gentiana I. , Hecker Dietmar , Wagenpfeil Gudrun , Furtwängler Rhoikos , Becker Sören L. , Papan Cihan , Graf Norbert , Simon Arne 
Published: February 2021

ZusammenfassungHintergrund Gentamicin kommt in vielen pädiatrisch onkologischen Behandlungszentren in der Erstlinien-Kombinationstherapie bei Fieber und Granulozytopenie zum Einsatz. Seit 2011 verwenden wir hierzu eine Dosierung von 250 mg/m2 KOF (max. 10 mg/kg, max. 400 mg) als tgl. Einmalgabe nach der deutschen Leitlinie.Patienten und Methoden In diesem prospektiven Audit (Februar 2011 – Dezember 2019) wurden bei 66 kinderonkologischen Patienten 105 Gentamicin-Zyklen in Hinblick auf die Adhärenz zum Dosierungsstandard und auf die Ergebnisse des Drug Monitorings analysiert.Ergebnisse Die Adhärenz mit dem neuen Dosierungsschema war hoch (89%). In 64% der Zyklen wurde ein Spitzenspiegel (1 h nach der 2. Gabe) im Zielbereich (Cmax; 10–20 µg/ml) erreicht. Cmax korrelierte signifikant mit der Dosis in mg/m2 KOF (p=0,007), jedoch nicht mit der Dosis in mg/kg (p=0,366). Ein Lebensalter unter 6 Jahre beeinflusste dieses Ergebnis nicht. Der Gentamicin Ctrough (8–10 h nach der zweiten Gabe) lag in 93% der Zyklen unter 2 µg/ml und korrelierte nicht mit der Dosis. Kein Patient in diesem Audit erfüllte die Kriterien für eine Gentamicin-assoziierte Nephrotoxizität.Diskussion und Schlussfolgerung Dieses prospektive Audit der tgl. Einmalgabe von Gentamicin bei nierengesunden pädiatrisch-onkologischen Patienten bestätigt die praktische Anwendbarkeit und Sicherheit der Dosierung in mg/m2 nach der deutschen Leitlinie. Aufgrund der eingeschränkten Indikationen für Gentamicin in der Erstlinientherapie ist eine prospektive multizentrische Studie zur Bestätigung dieser Beobachtungen wünschenswert.
PCDH12-Related Movement Disorder
Authors: Reddy Chaithanya , Paria Pradip , Bhanudeep Singanamalla , Bhatia Vikas , Saini Arushi G. 
Published: February 2021

AbstractProtocadherin 12 (PCDH12) is a member of a nonclustered group of cell surface proteins. Mutations in the PCDH12 gene can cause varied phenotypes ranging from epilepsy and movement disorders to congenital malformations and calcifications in neuroimaging. We discussed here a 14-year-old male patient with a movement disorder that mimicked dyskinetic cerebral palsy in the outpatient department; however, exome sequencing revealed a homozygous premature stop codon in exon 1 of the PCDH12(−) gene. The case highlights the importance of careful clinical examination to look for the features that do not match an assigned neurological syndrome and the need for follow-up neuroimaging to look for any progressive changes in all cases of unexplained movement disorder and intellectual impairment.
The social gradient in smoking: individual behaviour, norms and nicotine dependence in the later stages of the cigarette epidemic
Authors: Östergren Olof 
Published: February 2021

AbstractThe cigarette epidemic tends to develop in a similar pattern across diverse populations in different parts of the world. First, the prevalence of smoking increases, then it plateaus and finally it declines. The decline in smoking prevalence tends to be more pronounced in higher social strata. The later stages of the cigarette epidemic are characterized by emerging and persisting socioeconomic gradients in smoking. Due to its detrimental health consequences, smoking has been the subject of extensive research in a broad range of academic disciplines. I draw on literature from both the social and medical sciences in order to develop a model in which physiological nicotine dependence, individual smoking behaviour and norms surrounding smoking in the immediate social environment are related through reflexive processes. I argue that the emergence and persistence of social gradients in smoking at the later stages of the cigarette epidemic can be attributed to a combination of the pharmacological properties of nicotine, network homophily and the unequal distribution of material and non-material resources across social strata.
An efficient solution for correlative microscopy and co-localized observations based on multiscale multimodal machine-readable nanoGPS tags
Authors: Acher Olivier , Nguyên Thanh-Liêm , Podzorov Alexander , Leroy Matthieu , Carles Pierre-Alix , Legendre Sébastien 
Published: February 2021

Abstract
For a long time, investigating the same regions of interest of a sample with different instruments has been recognized as a very useful approach in various scientific fields. This paper presents an original solution for spotting the same points of interest with a high degree of accuracy and simplicity using different microscopes. It is based on small patterned tags fixed to the samples or their substrates. The patterns include an image-based position-sensing technology, for which an image of a small part of the tag can be automatically converted to absolute coordinates and angular orientation. Taking a single snapshot of the tag with an imaging instrument provides a correspondence between the sample and the coordinates of the moving stage. Co-localized observations performed with scanning electron microscopes, optical microscopes, and Raman microscopes are presented. The accuracy is in the range of a few µm up to 20 µm, which is generally sufficient to remove any ambiguity between the observed objects. The different contributions to colocalization errors are investigated experimentally and it is shown that errors related to the tags are negligible and that the main source of error is related to the accuracy of the moving stages integrated into the microscopes. A straightforward estimation of the relocalization error can be performed. It is believed that this solution will save researchers time and facilitate cooperation between laboratories.
YAG:Yb crystal with non-linear doping ions distribution as promising active element for high average power laser systems
Authors: Petrov V A , Petrov V V , Kuptsov G V , Laptev A V , Galutskiy V V , Stroganova E V 
Published: February 2021

Abstract
The influence of optical centers concentration profiles on thermal fields under high-power end-face diode pumping is analyzed using numerical model. It is shown that non-uniform distribution profiles of optical centers concentration are very promising for high average pump power laser amplifiers. The possibility of creating concentration profiles of optical centers in gradient-activated crystals with YAG matrix with a specified distribution along the growth axis of the crystal is demonstrated. A technology of growing gradient-activated single crystal involving active mirror as active element is proposed and discussed.
Quasi-monochromatic spectral emission characteristics from electron collision with tightly focused laser pulses
Authors: Zhuang Jiawei , Yan Yilv , Zhou Xi , Chen Zujie , Ren Shanling , Tian Youwei 
Published: February 2021

Abstract
The nonlinear Thomson backscattering of electrons interacting with a circularly polarized laser pulse is studied by using the single-electron model. By means of theoretical analysis and computer simulation, the influence of the central collision place and the beam waist radius on the spectral characteristics of the scattered light are discussed. It is indicated that the spectrum is nonlinear broadened as a result of redshifting of the Thomson scattered frequency. Only when the central collision point is set at a proper place under the tight focusing situation, can quasi-monochromatic x-rays be generated. Taking into account the requirements for the radiation intensity of scattered light, the optimum situation to generate quasi-monochromatic x-rays is explored. In addition, we find that the spectral and angular distribution of the backscattered light do not vary with azimuth angle.
19 × 1 high power pump combiner with large input core diameter
Authors: Zhang Hui , Lei Chengmin , Li Zhixian , Chen Zilun 
Published: February 2021

Abstract
In this paper, we investigate a 19 × 1 tapered fiber bundle (TFB) pump combiner for high power fiber lasers theoretically and experimentally, based on the twist method. Theoretically, we analyze the influence of the taper length, taper ratio and twist angle on the performance of a 19 × 1 TFB combiner by using the beam propagation method. Then, a 19 × 1 all-fiber combiner is fabricated experimentally, with input fibers and output fiber having core/clad diameter of 220/242 μm (numerical aperture (NA) = 0.22) and 30/600 μm (NA = 0.06/0.46) respectively. The transmission efficiency of each port is higher than 98.6% and the average efficiency of all 19 ports is 99.3%. The combiner achieved an output power of 1.5 kW with transmission efficiency of 99.3% when tested with four ports of 976 nm laser diode. To our best knowledge, this is the first time that 220/242 μm (NA = 0.22) multimode fibers act as the pump fibers of a 19 × 1 end-pumping combiner.
Almost Strongly Nncθe-continuous Functions
Authors: Sudha V. , Vadivel A. , Tamilselvan S. 
Published: February 2021

Abstract
We introduce and investigate a new class of functions called almost strongly Nnceθ-continuous functions via Nnce-open sets in Nnc
topological spaces. Also, some equivalent condition of almost strongly Nnceθ-continuous functions are proved.
CITD-number for some graph operations
Authors: Vimala Suganthi M. , Mahadeven G. 
Published: February 2021

Abstract
G. Mahadevan. et. al. initiated the concept of CITD-number. The set S ⊆ V is said to be Complementary independent twin paired dominating set, if S is a paired dominating set and < V − S > is a set of independent edges. The minimum cardinality taken over all the Complementary independent twin paired dominating set is called as Complementary independent twin paired domination number and it is denoted by CITD(G). We investigate this parameter for some graph operations.
Zagreb Indices of Vertex Based on IB Product
Authors: Pattabiraman K. , Suganya T. 
Published: February 2021

Abstract
A topological index is a numerical representation of a chemical structure which correlates certain physico-chemical characteristic of chemical compounds besides its numerical values. Zagreb index is the first degree based topological index which is proposed by Gutman et al.[2]in 1972. In this paper, we obtain the exact formulae for the Zagreb indices of new types and its coindices of two new types of graph operation based on indhu-bala product which is defined by Indulal and Balakrishnan [4] in 2016.
Novel Synthesis of NE, N′E-4,4′-sulfonylbis(N-(substituted-dichlorobenzylidene) anilines derivative their application biological and DFT studies
Authors: Enbaraj E. , Dhineshkumar E. , Jeyashri K. R. , Logeshwari G. , Ramya Devi V. J. , Manikandan H. , Seenivasan M. , Rajathi V. , Chakkaravarthy J. , Govindaraju R. 
Published: February 2021

Abstract
The structure of synthesized compounds has been established on the basis of their spectral (FT-IR, 1H&13C NMR and Mass) data. The purity of the compounds was confirmed by TLC. The compounds 1-3 were evaluated for their in vitro activity against several microbes. Compound 1-3 exhibited potent antibacterial activity with the reference standard ciprofloxacin and fluconazol. In the ground-state, compounds 1-3 molecular geometries were determined using the DFT based on B3LYP/6-31G(d, p) and compared to the experimental results. In addition, compounds 1-3, MEP maps and molecular frontier orbitals were performed, and the results obtained were compatible with the electronic properties.
The performance of salt farmer’s windmill from Demak for water pumping with low-speed centrifugal pump
Authors: Dio Zevalukito S , Lukiyanto Y B 
Published: February 2021

Abstract
Wind energy is a renewable energy source. Windmill generally used to convert shaft power to electrical power for battery charging. Another benefit of wind energy is wind power for pumping, which usually called windpump. Indonesian salt farmer uses traditional windmill for pumping water for salt production process. The piston lever of the reciprocating pump is directly connected to the windmill shaft. This study will discuss the performance of salt farmer windmills from Demak region with a low-speed centrifugal pump. The variation used in this study is the number of blades on the windmill. There are four blades and two blades. Windmill shaft rotation connected to the AC generator shaft with permanent magnet and then produce electricity. The electric power from the AC generator connected to the DC electric motor, then the DC electric motor rotating the low-speed centrifugal pump. Data required for this study are wind speed, windmill’s shaft speed, and volume flow rate. The results are at wind speed between 2 – 4.5 m/s, a windmill with four blades and two blades has 0.13 liter/s and 0.21 liter/s. The daily average volume for four blades and two blades has 2901.6 liters and 4492.8 liters. The maximum of total efficiency of the windpump system with four and two blades is 34.06% and 37.32%.
On Some Properties of Totally Irregular And Neighbourly Totally Irregular Hesitancy Fuzzy Graphs
Authors: Anantha Kanaga Jothi K. , Balsangu K. 
Published: February 2021

Abstract
In this paper, we introduce the concept of Totally Irregular Hesitancy Fuzzy Graphs and study the basic properties of totally irregular Hesitancy Fuzzy Graphs. We establish the relationship between the totally irregular, neighbourly totally irregular and highly totally irregular Hesitancy Fuzzy Graph..
New Ideas and Methods of Power System Planning in Market Economy
Authors: Wang Yue , Fang Bing , Feng Kaijian , Zheng Lijuan 
Published: February 2021

Abstract
With the deepening of domestic market economy, power plants and power grid companies are gradually separated from each other. The power generation company and the grid company participate in the power commodity trading in the market together with the users. In market economy, it is of great significance to make plan for power system, which directly affects the local economic development and maximizes the economic benefits of enterprises. There are new influencing factors in power system planning, in which the proportion of uncertain factors is relatively high, so that it upgrades the difficulty of power system planning. Therefore, the author first reorients the power system planning in market economy, followed by the analysis of the new evaluation criteria for power system planning, and then analyzes the ideas and methods of power system planning in market economy.
Influence of Coaxiality Deviation on Double-aperture Transmitter System in Wireless Laser Communication
Authors: Zhai Xuhua , Feng Suli 
Published: February 2021

Abstract
In order to study the influence of the coaxiality deviation on the received energy of the double-aperture transmission system in weak turbulence. The models of single and double-aperture transmission system are introduced, and the received energy of each link is calculated. Based on the interval of the link received energy, the coaxial deviation range and the angle variation of the double-aperture transmission system are calculated, and the effect factors of the different link distance and aperture spacing on coaxial deviation are also analyzed.
Resistance Welded Joint of TI6AL4V Alloy-PEI/GF Composite Reinforced By Candle Soot Coating
Authors: Wang Daosheng , Cui Xu , Dong Jiapeng , Deng Yingfan , Tian Lin 
Published: February 2021

Abstract
PEI/GF lamination and TI6AL4V alloy are often related to the poor wettability of PEI to TI6AL4V alloy at the interface layer. To overcome these problems, an in situ synthetic candle soot reinforcing coating on TI6AL4V alloy was added into the place of the bonding area. The mechanical properties of composite joints were evaluated by single lap shear strength (LSS) tensile test. The mechanism of strengthening TI6AL4V-PEI/GF joint by candle ash was compared.
Research on 3D Reconstruction methods Based on Binocular Structured Light Vision
Authors: Han Ruilu , Yan Hongjuan , Ma Liping 
Published: February 2021

Abstract
There are many studies on 3D reconstruction based on monocular vision, but for complex surface parts, contour occlusion problems will occur, which requires binocular or multi-eye vision for 3D reconstruction. This paper mainly uses binocular structured light vision to study 3D reconstruction. The specific methods are: use structured light coding to calibrate the binocular camera, the projector and the left and right cameras to obtain the calibration parameters, and then obtain the 3D coordinates based on the triangulation principle that there is only one intersection between the camera straight line equation and the projector plane equation in space. Because of the binocular structured light used in this article, the point clouds of the left and right cameras need to be merged to complete the stitching process of the two points clouds. Through the verification of this methods, the stitching error is good, and the point cloud can be streamlined later to improve the point cloud registration rate.