bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of knowledge silos in the adult blunt cerebrovascular injury literature
Authors: Schnurman Zane , Chagoya Gustavo , Jansen Jan O , Harrigan Mark R 
Published: December 2021

BackgroundBlunt cerebrovascular injuries (BCVI) remain a significant source of disability and mortality among trauma patients. The purpose of the present study was to determine whether knowledge silos exist in the overall BCVI literature.MethodsAn object-oriented programmatic script written in Python programming language was used to extract and categorize articles and references on the topic of BCVI. Additionally, each BCVI article was searched for by digital object identifier in the other BCVI references to build a network analysis and visualize topic reference patterns. Analyses were performed using Stata V.14.2 (StataCorp).ResultsA total of 306 articles with 10 282 references were included for analysis. Of these, 24% (74) were published in neurosurgery journals, 45% (137) were published in trauma journals, and 31% (95) were published in a journal of another specialty. Similar proportions were found when categorized by author departmental affiliation. Trauma surgery authors disproportionately referenced articles in the trauma literature, compared with neurosurgeons (73.5% vs. 48.0%, p<0.0001), and other authors. The biggest factor influencing reference proportions was the specialty of the publishing journal. Finally, a network analysis revealed that there are more trauma BCVI articles, and there are more frequently cited trauma BCVI articles by all specialties.ConclusionsThis study revealed the existence of a one-way knowledge silo in the BCVI literature. However, a robust preference by both trauma and neurosurgery to cite trauma references when publishing in trauma journals may indicate a possible conscious curating of citations by authors to increase the likelihood of publication. These observations highlight the need for an active role by journal editors, peer reviewers, and authors to actively foster diversity of citations and cross-specialty collaboration to improve dissemination of information between these specialties.Level of evidenceLevel IV. Observational study.
Primordial big bang nucleosynthesis and generalized uncertainty principle
Authors: Luciano Giuseppe Gaetano 
Published: December 2021

AbstractThe Generalized Uncertainty Principle (GUP) naturally emerges in several quantum gravity models, predicting the existence of a minimal length at Planck scale. Here, we consider the quadratic GUP as a semiclassical approach to thermodynamic gravity and constrain the deformation parameter by using observational bounds from Big Bang Nucleosynthesis and primordial abundances of the light elements $${}^4 He, D, {}^7 Li$$

4

H
e
,
D
,

7

L
i

. We show that our result fits with most of existing bounds on $$\beta $$
β
derived from other cosmological studies.
Assessing woody vegetation recovery in the Rayas River following the eruption of the Chaitén Volcano in 2008
Authors: Ulloa Héctor , Mazzorana Bruno , Iroumé Andrés , Paula Susana 
Published: December 2021

Abstract
We studied the recovery of the woody vegetation in a segment of the Rayas River, which drains the Chaitén Volcano, in southern Chile. Data collection in the river corridor was performed to assess the regeneration rates of the colonizing vegetation within the river corridor, to investigate the site-specific regeneration modes (i.e. with respect to the different morphological units), to determine the species composition and to observe potential similarities with the regeneration process on hillslopes (i.e. outside the river corridor). We first performed a sampling of the shrub and tree vegetation regenerating in the Forest adjacent to the study segment. Further sampling efforts were executed on Islands, High bars, the Floodplain, and in association with Wood jams. Results show that 9 years after the volcano's last eruption, pre-eruption remnant Islands and the Floodplain exhibited abundant regeneration, with the highest density of recruits and species richness. In addition, a clear difference was observed between the river corridor and the forest, both in the characteristics of the plants that were regenerating as well as in the species composition. Finally, the vegetation that has re-established after the eruption has not yet acquired the capacity to play a stabilizing role in the fluvial corridor. New insights are provided on reforestation patterns at sites impacted by large infrequent disturbances.
A Late Triassic vegetation record from the Huangshanjie Formation, Junggar Basin, China: possible evidence for the Carnian Pluvial Episode
Authors: Peng Jungang , Slater Sam M. , Vajda Vivi 
Published: December 2021

Abstract

The Carnian Pluvial Episode (CPE;
c.
234–232 million years ago) is characterized by an accelerated hydrological cycle, global warming and a period of elevated biotic turnover. Using spores and pollen, we reconstruct vegetation and climate changes through a Carnian–Norian (Upper Triassic) interval of the Huangshanjie Formation from the Junggar Basin, China. Four palynofloras were identified, representing distinct vegetation communities. Among these palynofloras, we observed a prominent shift from a conifer-dominated climax forest community, with common ginkgophytes and bennettites, to a fern-dominated community, suggestive of an environmental perturbation. We interpret this change as a regional shift in vegetation, likely caused by increased humidity, consistent with the CPE. Our records represent the first indication of a possible CPE-induced vegetation response in the Junggar Basin and highlight how this event likely affected floral communities of inland Laurasia.
DNMT3A-Mutant Leukemia Cells Primed to “Fork It Over” under DNA Damage
Authors: Viny Aaron D. 
Published: December 2021

Summary

Mutations in the gene DNMT3A have been identified in various hematopoietic conditions, including clonal hematopoiesis, myelodysplastic syndrome, and acute myeloid leukemia. The clinical significance of this early mutation and the resultant enhanced clonal fitness have been a focus for therapeutic intervention.
See related article by Venugopal et al., p. 756
cAMP-Mediated Autophagy Promotes Cell Survival via ROS-Induced Activation of PARP1: Implications for Treatment of Acute Lymphoblastic Leukemia
Authors: Richartz Nina , Pietka Wojciech , Gilljam Karin M. , Skah Seham , Skålhegg Bjørn S. , Bhagwat Sampada , Naderi Elin Hallan , Ruud Ellen , Blomhoff Heidi Kiil 
Published: December 2021

Abstract

DNA-damaging therapy is the basis for treatment of most cancers, including B-cell precursor acute lymphoblastic leukemia (BCP-ALL, hereafter ALL). We have previously shown that cAMP-activating factors present in the bone marrow render ALL cells less sensitive to DNA damage–induced apoptosis, by enhancing autophagy and suppressing p53. To sensitize ALL cells to DNA-damaging therapy, we have searched for novel targets that may counteract the effects induced by cAMP signaling. In the current study, we have identified PARP1 as a potential target. We show that the PARP1 inhibitors olaparib or PJ34 inhibit cAMP-mediated autophagy and thereby potentiate the DNA-damaging treatment. Furthermore, we reveal that cAMP-mediated PARP1 activation is preceded by induction of reactive oxygen species (ROS) and results in depletion of nicotinamide adenine dinucleotide (NAD), both of which are autophagy-promoting events. Accordingly, we demonstrate that scavenging ROS by N-acetylcysteine and repleting NAD independently reduce DNA damage-induced autophagy. In addition, olaparib augmented the effect of DNA-damaging treatment in a human xenograft model of ALL in NOD-scidIL2Rgammanull mice. On the basis of the current findings, we suggest that PARP1 inhibitors may enhance the efficiency of conventional genotoxic therapies and thereby provide a novel treatment strategy for pediatric patients with ALL.

Implications:
PARP1 inhibitors augment the DNA damage–induced killing of ALL cells by limiting the opposing effects of cAMP-mediated autophagy, which involves ROS-induced PARP1 activation and depletion of cellular NAD levels.
Right Heart Dysfunction in Adults With Coarctation of Aorta: Prevalence and Prognostic Implications
Authors: Egbe Alexander C. , Miranda William R. , Jain C. Charles , Connolly Heidi M. 
Published: December 2021

Background:
Chronic elevation of left heart filling pressure causes pulmonary vascular remodeling, pulmonary hypertension, and right heart dysfunction. Although diastolic dysfunction is relatively common in patients with coarctation of aorta, there are limited data about the prevalence and prognostic implications of pulmonary hypertension and right heart dysfunction in this population. The purpose of the study was to assess right heart function and hemodynamics in patients with coarctation of aorta and to determine the relationship between right heart indices and cardiovascular events defined as heart failure hospitalization, heart transplant, or cardiovascular death.

Methods:
Right heart structure, function, and hemodynamics were assessed with these indices: right atrial volume, right atrial pressure, right atrial reservoir strain, right ventricular global longitudinal strain, right ventricular end-diastolic area, right ventricular systolic pressure, and tricuspid regurgitation severity. Right heart hemodynamic score, range 0 to 5, was generated based on the correlation between the right heart indices and cardiovascular events, using half of the cohort (derivation cohort, n=411), and then tested on the validation cohort (n=410). The goodness of fit and discrimination power was compared using C statistics and risk score.

Results:
The median follow-up in the derivation cohort was 8.2 (4.0–11.1) years, and 59 (14%) patients had cardiovascular events during this period. Right heart hemodynamic score was independently associated with cardiovascular events (hazard ratio, 1.64 [95% CI, 1.38–2.17]) for every unit increase in right heart hemodynamic score after adjustment for clinical and echocardiographic indices (C statistic, 0.718 [95% CI, 0.682–0.746]). The right heart hemodynamic score was also independently associated with cardiovascular events in the validation cohort (C statistic, 0.711 [95% CI, 0.679–0.741]). The C statistic difference (0.007 [95% CI, 0.014–0.022]) and risk score (0.86 [95% CI, 0.54–1.17]) suggest a good model fit.

Conclusions:
The current study underscores the prognostic importance of right heart dysfunction in patients with coarctation of aorta and suggests that right heart indices should be used for risks stratification in this population.
Modular Grammatical Evolution for the Generation of Artificial Neural Networks
Authors: Soltanian Khabat , Ebnenasir Ali , Afsharchi Mohsen 
Published: December 2021

Abstract
This article presents a novel method, called Modular Grammatical Evolution (MGE), toward validating the hypothesis that restricting the solution space of NeuroEvolution to modular and simple neural networks enables the efficient generation of smaller and more structured neural networks while providing acceptable (and in some cases superior) accuracy on large data sets. MGE also enhances the state-of-the-art Grammatical Evolution (GE) methods in two directions. First, MGE's representation is modular in that each individual has a set of genes, and each gene is mapped to a neuron by grammatical rules. Second, the proposed representation mitigates two important drawbacks of GE, namely the low scalability and weak locality of representation, toward generating modular and multilayer networks with a high number of neurons. We define and evaluate five different forms of structures with and without modularity using MGE and find single-layer modules with no coupling more productive. Our experiments demonstrate that modularity helps in finding better neural networks faster. We have validated the proposed method using ten well-known classification benchmarks with different sizes, feature counts, and output class counts. Our experimental results indicate that MGE provides superior accuracy with respect to existing NeuroEvolution methods and returns classifiers that are significantly simpler than other machine learning generated classifiers. Finally, we empirically demonstrate that MGE outperforms other GE methods in terms of locality and scalability properties.
Women’s, Gender, and Sexuality Studies
Authors: Pearsall Sarah M.S. 
Published: December 2021

Abstract
This article, concentrating on trends in the field of gender and sexuality studies of the last decade or so, makes a case for expanding both the geography and the methodology for early modern gender studies, broadly conceived. Themes considered here include the intermingling of the intimate and the imperial as well as marriage, law, slavery and labor, freedom, settler colonialism, intersectionality, queer studies, mothering, and reproduction. This topic, and article, also point to the need to make use of material culture and to interrogate the silence and violence of the archive remaining.
Ensemble-Based Gravity Wave Parameter Retrieval for Numerical Weather Prediction
Authors: Allen Douglas R. , Hoppel Karl W. , Nedoluha Gerald E. , Eckermann Stephen D. , Barton Cory A. 
Published: December 2021

AbstractGravity wave (GW) momentum and energy deposition are large components of the momentum and heat budgets of the stratosphere and mesosphere, affecting predictability across scales. Since weather and climate models cannot resolve the entire GW spectrum, GW parameterizations are required. Tuning these parameterizations is time-consuming and must be repeated whenever model configurations are changed. We introduce a self-tuning approach, called GW parameter retrieval (GWPR), applied when the model is coupled to a data assimilation (DA) system. A key component of GWPR is a linearized model of the sensitivity of model wind and temperature to the GW parameters, which is calculated using an ensemble of nonlinear forecasts with perturbed parameters. GWPR calculates optimal parameters using an adaptive grid search that reduces DA analysis increments via a cost-function minimization. We test GWPR within the Navy Global Environmental Model (NAVGEM) using three latitude-dependent GW parameters: peak momentum flux, phase-speed width of the Gaussian source spectrum, and phase-speed weighting relative to the source-level wind. Compared to a baseline experiment with fixed parameters, GWPR reduces analysis increments and improves 5-day mesospheric forecasts. Relative to the baseline, retrieved parameters reveal enhanced source-level fluxes and westward shift of the wave spectrum in the winter extratropics, which we relate to seasonal variations in frontogenesis. The GWPR reduces stratospheric increments near 60°S during austral winter, compensating for excessive baseline nonorographic GW drag. Tropical sensitivity is weaker due to significant absorption of GW in the stratosphere, resulting in less confidence in tropical GWPR values.
Psychophysical testing in chronic migraine and chronic tension type headache: An observational study
Authors: Elizagaray-García Ignacio , Carvalho Gabriela F , Szikszay Tibor M , Adamczyk Waclaw M , Navarro-Fernández Gonzalo , Alvarez-Testillano Paula , Díaz-de-Terán Javier , Luedtke Kerstin , Gil-Martínez Alfonso 
Published: December 2021

Background Clinical presentation is the key to the diagnosis of patients with migraine and tension-type headache, but features may overlap when both become chronic. Psychophysical parameters may distinguish both conditions. We aimed to compare psychophysical aspects of patients with chronic migraine, chronic tension-type headache and headache-free controls, and to determine whether these can predict headache frequency. Methods An examiner blinded to the diagnosis assessed 100 participants (chronic migraine (n = 38), chronic tension-type headache (n = 31) and controls (n = 31)). Assessed variables included painful area, pressure pain thresholds, temporal summation, cervical range of motion, neck posture, headache and neck impact, quality of life, and kinesiophobia. Comparison between groups was performed with one-way ANOVA and multiple linear regression was used to assess the headache frequency predictors. Results We found differences of both headache groups compared to controls ( p < 0.01), but not between headache groups. Neck disability was a significant predictor of headache frequency for chronic tension-type headache (adjusted R2 = 0.14; β = 0.43; p = 0.03) and chronic migraine (adjusted R2 = 0.18; β = 0.51; p < 0.01). Conclusions Chronic tension-type headache and chronic migraine showed similar psychophysical results, but were significantly worse when compared to controls. The psychophysical examination did not discriminate between headache types. The variable best explaining headache frequency for both headache types was neck disability.
Social Information and Gender Differences in Competitive Preferences
Authors: Roby Christopher 
Published: December 2021

This is an exploratory study that examines the effect of social information on gender differences in selection into a winner-take-all tournament, using a simple addition task. Participants perform this task in multiple rounds and then select into a competitive or non-competitive pay scheme. Prior to choosing payment schemes, participants are shown selected results about average performance and choices in a similar experiment. I find that the inclusion of social information eliminates any extant gender gap in competitive choices in every treatment. The reduction in the gender gap is not due to greater efficiency of choices by men or women, even though inefficient choices by low-performing individuals are mostly eliminated. Rather, the inclusion of feedback causes men and women to select into a competitive pay scheme in a similar manner, thereby removing the gender gap. Despite these results, the complexity of the social information intervention used leaves some results unexplained. JEL Classifications: C9, J2, J16.
Characterization of the Transition Zone in Short Segment Hirschsprung Disease Using Calretinin Immunostaining
Authors: Righini-Grunder Franziska , Bouron-Dal Soglio Dorothée , Hart Lara , Aspirot Ann , Faure Christophe , Patey Natacha 
Published: December 2021

Introduction: The detailed expression pattern of calretinin immunohistochemistry in the transition zone (TZ) of Hirschsprung disease (HSCR) has not yet been reported. This study aims to examine the value of calretinin immunohistochemistry for more accurately determining the distal and proximal border of the TZ in short segment HSCR. Methods: Specimens of pull-through surgery from 51 patients with short form of HSCR were analyzed on two longitudinal strips using hematoxylin and eosin (H&E) staining and calretinin immunohistochemistry. Results: In all but two patients, the first appearance of calretinin expression was seen on mucosal nerve fibers before the appearance of any ganglion cells, indicating the distal border of the TZ. The maximum distance between the distal border of the TZ and the proximal border of the TZ, defined by ganglion cells in a normal density on H&E stained sections, a strong calretinin expression on mucosal nerve fibers and in >80% of submucosal and myenteric ganglion cells, with no nerve hypertrophy and absence of ganglionitis was 60 mm. Conclusion: The distal border of the TZ is characterized by calretinin positive intramucosal neurites in nearly all of short form of HSCR and not by calretinin expression on ganglion cells.
Intraoperative dexamethasone intravitreal implant in diabetic macular edema patients undergoing phacoemulsification: The CataDex study
Authors: Vadalà Maria , Trapani Valentina Sunseri , Amato Mario , Bongiovanni Giuseppe , Alaimo Francesco , Cillino Salvatore , Bonfiglio Vincenza Maria Elena 
Published: December 2021

Purpose To assess the impact of preoperative intravitreal dexamethasone implant (DexI) on functional and anatomic outcomes in patients with diabetic macular edema (DME) who underwent phacoemulsification cataract surgery. Methods Prospective and non-comparative study conducted on consecutive DME patients undergoing cataract surgery. DexI was administered 15 days before surgery and in a pro re nata regime after surgery. Main outcome measures were mean change in central retinal thickness (CRT), central subfield thickness (CST), total macular volume (TMV), and central subfield volume (CSV) from baseline to month-12. Secondary outcome was mean change in best corrected visual acuity (BCVA). Results Forty eyes were included in the study. CRT significantly decreased from 410.4  ±  64.8 µm at baseline to 303.2  ±  24.3 µm at month-12, p < 0.0001. Similarly, CST was significantly reduced from 436.4  ±  120.4 µm at baseline to 322.9  ±  54.2 µm at month-12, p < 0.0001. Total macular volume and CSV were significantly reduced from 9.95  ±  1.68 mm3 and 0.38  ±  0.11 mm3 at baseline to 8.49  ±  0.83 mm3 and 0.31  ±  0.05 mm3 at month-12, respectively ( p < 0.0001 each, respectively). BCVA significantly improved from 0.26  ±  0.17 Snellen equivalent at baseline to 0.65  ±  0.19 at month-12, p < 0.0001. Mean DexI administered during the study were 2.0  ±  0.3. Neither DME subtype nor previous treatment status had any effect on functional or anatomic outcomes. Regarding safety, one (2.5%) eye developed ocular hypertension, which was successfully controlled with topical hypotensive treatment. Conclusions DexI was and effective and safe strategy for managing DME in diabetic patients undergoing uneventful cataract surgery.
Culturally safe health care practice for Indigenous Peoples in Australia: A systematic meta-ethnographic review
Authors: De Zilva Stephanie , Walker Troy , Palermo Claire , Brimblecombe Julie 
Published: December 2021

Objectives Culturally safe health care services contribute to improved health outcomes for Aboriginal and Torres Strait Islander Peoples in Australia. Yet there has been no comprehensive systematic review of the literature on what constitutes culturally safe health care practice. This gap in knowledge contributes to ongoing challenges providing culturally safe health services and policy. This review explores culturally safe health care practice from the perspective of Indigenous Peoples as recipients of health care in Western high-income countries, with a specific focus on Australian Aboriginal and Torres Strait Islander Peoples. Methods A systematic meta-ethnographic review of peer-reviewed literature was undertaken across five databases: Ovid MEDLINE, Scopus, PsychINFO, CINAHL Plus and Informit. Eligible studies included Aboriginal and Torres Strait Islander Peoples receiving health care in Australia, had a focus on exploring health care experiences, and a qualitative component to study design. Two authors independently determined study eligibility (5554 articles screened). Study characteristics and results were extracted and quality appraisal was conducted. Data synthesis was conducted using meta-ethnography methodology, contextualised by health care setting. Results Thirty-four eligible studies were identified. Elements of culturally safe health care identified were inter-related and included personable two-way communication, a well-resourced Indigenous health workforce, trusting relationships and supportive health care systems that are responsive to Indigenous Peoples’ cultural knowledge, beliefs and values. Conclusions These elements can form the basis of interventions and strategies to promote culturally safe health care practice and systems in Australia. Future cultural safety interventions need to be rigorously evaluated to explore their impact on Indigenous Peoples’ satisfaction with health care and improvements in health care outcomes.