bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster
Authors: El Fissi Najla , Rosenberger Florian A. , Chang Kai , Wilhalm Alissa , Barton-Owen Tom , Hansen Fynn M. , Golder Zoe , Alsina David , Wedell Anna , Mann Matthias , Chinnery Patrick F. , Freyer Christoph , Wredenberg Anna 
Published: December 2024

AbstractAberration of mitochondrial function is a shared feature of many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics of the mitochondrial network. While some of these changes serve as compensatory mechanisms to maintain cellular homeostasis, their chronic activation can permanently affect cellular metabolism and signalling, ultimately impairing cell function. Here, we use a Drosophila melanogaster model expressing a proofreading-deficient mtDNA polymerase (POLγexo-) in a genetic screen to find genes that mitigate the harmful accumulation of mtDNA mutations. We identify critical pathways associated with nutrient sensing, insulin signalling, mitochondrial protein import, and autophagy that can rescue the lethal phenotype of the POLγexo- flies. Rescued flies, hemizygous for dilp1, atg2, tim14 or melted, normalise their autophagic flux and proteasome function and adapt their metabolism. Mutation frequencies remain high with the exception of melted-rescued flies, suggesting that melted may act early in development. Treating POLγexo- larvae with the autophagy activator rapamycin aggravates their lethal phenotype, highlighting that excessive autophagy can significantly contribute to the pathophysiology of mitochondrial diseases. Moreover, we show that the nucleation process of autophagy is a critical target for intervention.
Adaptive metal ion transport and metalloregulation-driven differentiation in pluripotent synthetic cells
Authors: Higashi Sayuri L. , Zheng Yanjun , Chakraborty Taniya , Alavizargar Azadeh , Heuer Andreas , Wegner Seraphine V. 
Published: December 2024

AbstractPluripotent cells can yield different cell types determined by the specific sequence of differentiation signals that they encounter as the cell activates or deactivates functions and retains memory of previous inputs. Here, we achieved pluripotency in synthetic cells by incorporating three dormant apo-metalloenzymes such that they could differentiate towards distinct fates, depending on the sequence of specific metal ion transport with ionophores. In the first differentiation step, we selectively transported one of three extracellular metal ion cofactors into pluripotent giant unilamellar vesicles (GUVs), which resulted in elevation of intracellular pH, hydrogen peroxide production or GUV lysis. Previously added ionophores suppress transport with subsequent ionophores owing to interactions among them in the membrane, as corroborated by atomistic simulations. Consequently, the addition of a second ionophore elicits a dampened response in the multipotent GUV and a third ionophore results in no further response, reminiscent of a terminally differentiated GUV. The pluripotent GUV can differentiate into five final fates, depending on the sequence in which the three ionophores are added.
Reliable long-term individual variation in wild chimpanzee technological efficiency
Authors: Berdugo S. , Cohen E. , Davis A. J. , Matsuzawa T. , Carvalho S. 
Published: December 2024

AbstractVariation in the efficiency of extracting calorie-rich and nutrient-dense resources directly impacts energy expenditure and potentially has important repercussions for cultural transmission where social learning strategies are used. Assessing variation in efficiency is key to understanding the evolution of complex behavioural traits in primates. Here we examine evidence for individual-level differences beyond age- and sex-class in non-human primate extractive foraging efficiency. We used 25 years (1992–2017) of video of 21 chimpanzees aged ≥6 years in Bossou, Guinea, to longitudinally investigate individual-level differences in stone tool use efficiency. Data from 3,882 oil-palm nut-cracking bouts from >800 h of observation were collected. We found reliability in relative efficiency across four measures of nut-cracking efficiency, as well as a significant effect of age. Our findings highlight the importance of longitudinal data from long-term field sites when investigating underlying cognitive and behavioural diversity across individual lifespans and between populations.
Harnessing multimodal approaches for depression detection using large language models and facial expressions
Authors: Sadeghi Misha , Richer Robert , Egger Bernhard , Schindler-Gmelch Lena , Rupp Lydia Helene , Rahimi Farnaz , Berking Matthias , Eskofier Bjoern M. 
Published: December 2024

AbstractDetecting depression is a critical component of mental health diagnosis, and accurate assessment is essential for effective treatment. This study introduces a novel, fully automated approach to predicting depression severity using the E-DAIC dataset. We employ Large Language Models (LLMs) to extract depression-related indicators from interview transcripts, utilizing the Patient Health Questionnaire-8 (PHQ-8) score to train the prediction model. Additionally, facial data extracted from video frames is integrated with textual data to create a multimodal model for depression severity prediction. We evaluate three approaches: text-based features, facial features, and a combination of both. Our findings show the best results are achieved by enhancing text data with speech quality assessment, with a mean absolute error of 2.85 and root mean square error of 4.02. This study underscores the potential of automated depression detection, showing text-only models as robust and effective while paving the way for multimodal analysis.
Open‐set recognition of specific emitter based on complex‐valued convolutional neural network
Authors: Sun Chengyuan , Zhang Tao , Du Yihang , Zhang Jiang 
Published: December 2024

AbstractSpecific emitter identification (SEI) plays an important role in enhancing physical layer transmission security. However, with the promotion of wireless technology, the environment is filled with a large number of unknown wireless signals. SEI will face a more challenging scenario referred to as “open set.” To cope with the above difficulties, an open‐set recognition (OSR) model based on complex‐valued convolutional neural network (CVCNN) is proposed. The CVCNN can adapt to IQ signal input and extract complex domain features. Furthermore, a novel inter‐class loss is proposed to effectively improve the classification performance. Finally, the classifier is designed based on the incremental approach. It can continuously learn new classes to achieve the recognition of multiple unknown emitters. The experiments show that compared with the real‐valued convolutional neural network and the single loss function, the accuracy is improved by 3.8% and 10%, respectively.
Massive stellar triples on the edge
Authors: Bruenech C. W. , Boekholt T. , Kummer F. , Toonen S. 
Published: December 2024

Context. Massive stars reside predominantly in triples or higher-order multiples. Their lives can be significantly affected by three-body interactions, making it an important area of study in the context of massive-star evolution.
Aims. We intend to provide a statistical overview of the lives and final outcomes of massive triples that are born dynamically stable but become unstable due to evolutionary processes.
Methods. We evolved a population of initially stable triples with a massive primary star from the zero-age main sequence (ZAMS) using the code TRES, which combines stellar evolution (SE) with orbit-averaged dynamics. The triples that become unstable were transferred to a direct N-body code, where they were simulated until the system disintegrated. This excludes systems undergoing mass transfer, where the instability is caused by stellar winds or supernova explosions. We performed two suites of N-body simulations; one with gravity as the only interaction, and one with SE included.
Results. We find that our triples remain on the edge of stability for a long time before disintegrating, making SE a consequential process during this phase. Eventually, the destabilisation results in either the ejection of a stellar body or the collision between two components. We find that collisions occur in 35 − 40% of systems, with the variation in this percentage coming from whether or not SE is included. The collisions predominantly involve two main sequence (MS) stars (70 − 78%) or a MS and post-MS star (13 − 28%). We estimate the Galactic rate of collisions due to massive triple destabilisation to be at 1.1 − 1.3 events per million years. Furthermore, we find that the process of destabilisation often ends in the ejection of one of the stellar bodies, specifically for 31 − 40% of systems. The ejected bodies have typical velocities of ∼6 km/s, with a tail stretching to 102 km/s. If we make the assumption that 20% of massive stars are runaway stars, then 0.1% of runaways originate from triple destabilisation. Overall, our simulations show that triple instability affects approximately 2% of massive triples. However, we estimate that up to ten times as many systems can become unstable due to mass transfer in the inner binary, and these system may end up ejecting bodies at higher velocities.
Blood loss in one-stage bilateral total knee arthroplasty: cruciate-retaining vs. posterior stabilized. A propensity score-matched analysis
Authors: Laoruengthana Artit , Tantimethanon Thanawat , Santisathaporn Nopparat , Inta-ngam Thisayapong , Pongpirul Krit , Rattanaprichavej Piti 
Published: December 2024

Introduction: Although single-stage bilateral total knee arthroplasty (BTKA) presents several advantages, higher perioperative blood loss is a potentiate drawback that is still inevitable. Cruciate retaining (CR) TKA may theoretically result in less blood loss, offer better proprioception, and more physiologic kinematics compared to posterior stabilized (PS) TKA. The objective of this study was to compare perioperative blood loss and recovery among patients who underwent CR and PS BTKA. Methods: A cohort of 46 CR BTKA and 80 PS BTKA performed by a single surgeon were retrospectively evaluated. Identical surgical techniques and perioperative care were provided to all patients. Propensity score matching was utilized to compare blood loss, a visual analog scale (VAS) for postoperative pain level, morphine consumption, knee flexion arc, and length of stay (LOS). Results: Comparing CR BTKA and PS BTKA, drain output was 206.44 mL vs. 194.89 mL (p = 0.47), calculated blood loss was 886.23 mL vs. 724.89 mL (p = 0.05), and blood transfusion rate was 18% vs. 17% (p = 1.00). Additionally, CR BTKA had higher VAS than PS BTKA, at 6 h: 5.74 vs. 3.78 (p < 0.001), and at 12 h: 5.80 vs. 4.74 (p = 0.02). CR BTKA group had higher morphine consumption (26.87 mg vs. 19.74 mg; p = 0.01) in the first 48 h. CR BTKA showed significantly less knee flexion angle during 48–72 h postoperative. Conclusions: The use of the CR prosthesis in BTKA could not demonstrate a superiority over the PS design in terms of blood loss, and recovery of knee function during the acute postoperative period.
The Pillars Concept: An Approach for Managing Hypertrophic Concha in Otoplasty
Authors: Neves José Carlos , Arancibia-Tagle Diego 
Published: December 2024

AbstractProminent ear deformities often result from a combination of hypertrophic conchal cartilage and an underdeveloped antihelical fold. Traditional otoplasty techniques, such as antihelical folding sutures and conchal setback maneuvers, may introduce tension and risk of relapse, leading to suboptimal aesthetic outcomes. The Pillars Concept represents an alternative surgical approach specifically designed to address hypertrophic concha, ensuring stable and natural results.This study aimed to present the Pillars Concept as an alternative method for correcting hypertrophic conchal cartilage, highlighting its advantages over traditional techniques, and evaluating its effectiveness in maintaining long-term stability of the ear's position without relapse.A retrospective analysis was conducted on 89 patients who underwent otoplasty utilizing the Pillars Concept. The technique involves selective transection of two supporting pillars located in the superior and inferior conchal regions after partial resection of the hypertrophic concha. This releases the conchal cartilage and enables tension-free repositioning of the auricular framework.Of the 89 cases, no hypertrophic concha recurrences were noted during follow-up periods. Complications were minimal, with only two patients (2.2%) experiencing a sensation of “glued ears” following complete conchal resection. Retroauricular fullness was observed in two cases (2.2%) after conchal setback, primarily due to inadequate management of the residual cartilage length. Patient satisfaction was high, and the natural aesthetic of the auricle was consistently preserved.The Pillars Concept provides a reliable, tension-free method for addressing hypertrophic conchal cartilage in otoplasty, preserving the natural ear anatomy and ensuring long-term stability without the risk of relapse. This technique should be considered a valuable addition to the armamentarium of otoplasty procedures.
Arachnoid Cyst as a Late Complication of Selective Dorsal Rhizotomy: A Case Report
Authors: van Noort Maya T. , van Schie Paul , Slot K. Mariam , van de Pol Laura A. , Buizer Annemieke I. , de Groot Vincent 
Published: December 2024

Abstract
Background and importance Selective dorsal rhizotomy (SDR) is a surgical technique to treat spasticity, mainly in children with spastic cerebral palsy (CP). In this report, a unique case of a late arachnoid cyst, causing radiating pain in the left leg, is presented. This is relevant to clinicians managing the long-term follow-up of patients who underwent selective dorsal rhizotomy (SDR).
Clinical presentation A 25-year-old male with bilateral spastic CP, who underwent SDR at the age of 7, presented with symptoms of progressive radiating pain in the left leg. Magnetic resonance imaging (MRI) revealed the presence of a large arachnoid cyst and a remarkable dorsal position of the cauda equina. After dissection of the cyst, the previously experienced radiating pain immediately subsided; however, the patient developed urinary retention and constipation. Cauda compression was ruled out by MRI. The constipation subsided quickly, and the patient performed self-catheterization until 1 month postoperatively for the urinary retention after which there were no signs of ongoing bladder dysfunction.
Conclusion Arachnoid cyst formation can be a late complication of SDR and can cause lumbosacral radicular syndrome in the late postoperative course in select cases.
Digestive endoscopic removal of cocaine pellets: Safety evaluation
Authors: Aboikoni Alolia , Wallyn Marion , Bonifay Timothée , Chhorn Piseth , Sylla Balandougou , Alogo A Nwatsok Marthe , Becar Alix , Ngock Dime Paul , Nguyen Thi Thu Nga , Fremery Alexis , Garzelli Lorenzo , Aissaoui Houari , Zappa Magaly , Louvel Dominique 
Published: December 2024

AbstractRemoval of cocaine pellets by endoscopy is the subject of much debate, due to the supposed risk of rupture. This study aimed to evaluate the safety of digestive endoscopic removal of cocaine pellets.This was a single-center, observational, retrospective study conducted at the Cayenne Hospital in French Guiana from July 2015 to May 2023. We included patients in whom digestive endoscopy was performed for delayed evacuation despite conservative treatment defined by persistence of pellets on imaging from the third day of hospitalization. Endoscopy was performed only if the pellets present were at low risk of rupture (type 4 according to the classification by Pidoto in 2002). We collected demographic, imaging, endoscopic and follow-up data.We included 111 patients, 75% of whom were male. Median age was 25 years (range, 20–33). Imaging was performed in 99% of cases. On imaging prior to endoscopy, pellets were found mainly in the stomach (28%), right colon (28%), left colon (30%), and sigmoid (31%). Median time to endoscopy was 3 days (range, 2.5–4). Median number of pellets extracted endoscopically was one (range, 1–4). The material used was mainly endoscopic baskets (60%). No patient presented any per or post-endoscopic complications. No pellets ruptured during extraction. There was no sign of cocaine intoxication during or after endoscopy. The success rate for pellet removal was 92% during the first endoscopy and 100% during the second endoscopy.Endoscopic removal of micro-industrially-produced cocaine pellets seems to be a safe and effective method. Therefore, endoscopy has a place in management of these patients.
Descripción anatómica del colgajo de pronador cuadrado en población Colombiana. Estudio cadavérico
Authors: Gutierrez Pilonieta Juan Felipe , Amador Nahala Fahed Aborashed , Barreto Camilo José Romero , de la Hoz José 
Published: December 2024

Resumen
Introducción Existe un incremento en el uso del pronador cuadrado (PQ) como colgajo funcional para reconstrucciones faciales y en miembro superior predominantemente, basado en el pedículo de arteria y nervio interóseo anterior, no obstante la literatura con relación a las dimensiones de los componentes del mismo, aunque creciente, es escasa especialmente en población Latinoamericana. Por lo cual se realizó la descripción morfológica de las dimensiones del músculo, arteria, nervio y venas concomitantes.
Materiales y Métodos Las disecciones fueron realizadas en 10 antebrazos de 10 componentes cadavéricos en el CLEMI. Se tomaron medidas y material fotográfico de las dimensiones del músculo y pedículo neurovascular, para su posterior análisis estadístico.
Resultados Posterior al análisis estadístico se estableció para el músculo una media de 4.3 cm de ancho, 4.8 cm de largo y 0.9 cm de grosor, en cuanto a la arteria interósea anterior (AIA) se evidenció una longitud media 12.5 cm con diámetro proximal y distal de 1.6 mm y 2.2 mm respectivamente y anastomosis con la arteria interósea posterior (AIP) en 80% de los casos. En relación con el nervio interóseo anterior (NIA), presentó una longitud y diámetro promedio de 12.2 cm y 0.9 mm respectivamente, con una distancia de 9.8 cm desde la rama del flexor pollicis longus (FPL) hasta el pronador cuadrado y 13.7 cm desde el pliegue de la muñeca. Se evidenció una vena única en 60% de los casos con diámetro de 0.9 mm.
Conclusión Se apreció una anatomía constante en el colgajo de pronador cuadrado, con arteria, vena y nervio de adecuada longitud y diámetro para una fácil anastomosis y neurorrafia, asociado a una baja morbilidad de la zona donante, configurándose como una herramienta útil en el proceso reconstructivo.
Tratamiento de la inestabilidad en plano sagital de la articulacyón interfalángica proximal: Técnica de escarificación ecoguiada de la placa volar
Authors: Barrera-Ochoa Sergi , Prieto-Mere Jose Antonio , Ibañez Federico , Font Eduard , Sosa Gustavo , Martinez-Garza Julio , Soldado Francisco 
Published: December 2024

Resumen
Introducción La laxitud en la placa volar de la articulación interfalángica proximal puede traducirse en una inestabilidad en el plano sagital por incompetencia de esta, acompañada de una hiperextensión digital con subluxación dorsal, perdida de funcionalidad y dolor.
Objetivos Presentar una serie de casos de pacientes con inestabilidad sagital en la interfalángica proximal tratado mediante una técnica quirúrgica mínimamente invasiva y evaluando los resultados a corto y mediano plazo.
Material y Métodos Pacientes tratados con una técnica quirúrgica mínimamente invasiva que implica escarificación de la placa volar guiada por ultrasonido para el tratamiento de una deformidad en hiperextensión por incompetencia de la placa volar. Esta técnica se ha utilizado en cinco pacientes en un estudio prospectivo con un seguimiento de un año, donde a la técnica percutánea le sigue un protocolo de ferulización y rehabilitación articular.
Resultados Resultados satisfactorios que muestran una reducción del dolor y una mejor función, con una tasa de resolución de la hiperextensión y del bloqueo articular en un 100%, y una mejora en el Quick-DASH y Mayo Wrist Score.
Report on the key comparison, CCM.F-K23 in force at 200 N and 500 N
Authors: Wuethrich Christian , Guzman Jorge Torres , Germak Alessandro , Kim Min-Seok , Averlant Philippe , Jiang Jile , Chesnutwood Kevin , Hayashi Toshiyuki , Röske Dirk 
Published: December 2024

Main text
The comparison CCM.F-K23 is a key comparison in force involving nine laboratories in three regional metrological organizations (RMO). The comparison adopted a scheme where each participant provides its own set of transfer standards. The measurements have been realized in 2020 and the equivalence between the participants is demonstrated.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Geometric control of honeycomb superlattice plasma photonic crystals in dielectric barrier discharge
Authors: Deng Tengkun , Wang Zihao , Liu Fucheng , Wang Jing , Wang Shuo , Wang Qihan , Fan Weili 
Published: December 2024

Abstract
We propose a scheme for dynamically controlling the geometric configurations of honeycomb superlattice plasma photonic crystals (HsPPCs) in dielectric barrier discharge. A rapid transition from a simple honeycomb lattice to diverse HsPPCs has been achieved in ambient air. The HsPPCs exhibit substantial omnidirectional band gaps (OBGs), approximately three times larger than those of simple honeycomb lattices. An experimental verification of the OBGs as well as their frequency shifting with reconfiguration of different HsPPCs has been provided. A phenomenological reaction-diffusion system is developed to unravel the generation mechanism of HsPPCs. The experimental observations are consistent with the numerical simulations. Our approach provides a unique method for manufacturing tunable HsPPCs which significantly enhance the band gap size and improve the photonic properties.
Real-time electron density measurement technique using a microwave resonant probe for low-pressure plasmas
Authors: Boni Federico , Jarrige Julien , Désangles Victor 
Published: December 2024

Abstract
This paper presents a technique to perform a time-resolved electron density measurement in a plasma using a microwave resonant probe named curling probe and a Voltage Controlled Oscillator fast-swept circuit. The technique is an interesting alternative to the Vector Network Analyzer used in on-point mode on repetitive triggered discharges as it also works for non-repeatable events or in cases where trigger signals are unavailable. First, the temporal resolution of the presented setup is assessed to be 5 µs with an uncertainty on the electron density of 5 × 107 cm−3. Second, the accuracy of the diagnostic is successfully demonstrated by measuring similar electron density for different measurement rates and by measuring forced plasma oscillations at 25 kHz in a magnetic nozzle thruster. Third, the ability of the diagnostic to perform real-time measurements is demonstrated by capturing the transient dynamic of the electron density during the switch-off of the thruster, with a fast plasma density variation of the order of 6 × 107 cm−3/µs being measured during the first tens of microseconds after plasma extinction.