bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous Ondansetron to Prevent Hypotension During Cesarean Section under Spinal Anaesthesia
Authors: Bhiwal Anil Kumar , Chauhan Kunal , Choudhary Savita , Bhatt Heena A. , Gupta Sunanda 
Published: April 2021

Background:
Spinal anesthesia for cesarean section (CS) is associated with common side effects like hypotension and bradycardia. Ondansetron, a 5HT3 receptor antagonist, inhibits Bezold-Jarish reflex and has been found to be effective for prevention of spinal-induced hypotension for elective cesarean section.

Aims:
The aim of this study was to evaluate the effect of two different doses of ondansetron as prophylaxis to prevent hypotension during spinal anesthesia for caesarean section.

Materials and Methods:
This prospective randomized double-blinded controlled study was conducted on 150 full-term parturients undergoing CS under spinal anesthesia, who were divided into three groups, receiving saline or different drug doses: Group C: 0.9% Normal Saline 10 ml; Group O4: 4 mg Ondansetron in 8 ml NS; or Group O8: 8 mg Ondansetron in 6 ml NS, 5 min before spinal anesthesia. All the patients were monitored for blood pressure, heart rate, vasopressor requirement, and side effects. Hemodynamic variables and demographic data were compared by analysis of variance (ANOVA) and Chi-square test was used for analyzing adverse effects and P value <0.05 was considered significant.

Results:
Intraoperative incidence of hypotension was significantly high (P < 0.001) in group C (58%) as compared to group O8 (16%) and group O4 (31.25%) but comparable between ondansetron groups (O8 vs. O4) (P = 0.074). Total requirement of ephedrine (mg) was significantly higher (P < 0.01) in group C (5.02 ± 4.95) as compared to group O8 (1.2 ± 3.20) and O4 (3.00 ± 4.88). It was found to be significantly higher (P = 0.034) in group O4 when compared with group O8. Mean HR, SBP, DBP, MAP was decreased more in group C at different time intervals.

Conclusions:
Prophylactic intravenous ondansetron reduced the incidence of hypotension and requirement of vasopressors in parturients undergoing CS under spinal anesthesia, with a further decrease in requirement of vasopressor in Group O8.
Evaluation of patient satisfaction and the service quality of the outpatient care at the Heart Institute of Ho Chi Minh City
Authors: Thuy Dinh Hong Diem , Phuong Tran Thi Thanh , Khanh Nguyen Huu , Vien Nguyen Truong 
Published: April 2021

Background and aims: This study assesses the levels and determinants of patient satisfaction with outpatient care at the Heart Institute of Ho Chi Minh City in 2018.
Methods: A cross-sectional descriptive survey was carried among 401 randomly selected outpatients at the Heart Institute of Ho Chi Minh City from June to November 2018. The data were collected on pre-designed and pre-tested questionnaire that contained 32 items. The survey examined four main aspects of the service quality: “the accessibility of healthcare services”, “the transparency of information and procedures”, “the quality of the medical infrastructure and facilities”, “the behavior and professional competence of medical and service staff”. The survey asked the patients to evaluate the outcome of service delivery and satisfaction based on the 5 levels Linkert scale. Descriptive statistics, factor analysis and multiple linear regressions were performed to test the hypothesized relationships between service quality and patient satisfaction with the outpatient care.
Results: Satisfaction of patients and relatives of patients about the quality of outpatient care was high, reaching the average 87.3 percent of patients’ expectation with the minimum of 50 to 100. 30% patients were not satisfied towards the booking appointments via phone, and online services. 35% patients were not happy with the long times waiting to get the registration, to see the doctors, to do the investigations and receive the results, and 54.1% respondents were not happy with toilet and drinking water facilities. Three dimensions of service quality significantly impacted the patient satisfaction and the outcome of service delivery: “the transparency of the information”, “the behavior and competence of medical staff and service staff”, and “the quality of the medical infrastructure and facilities”. The level of satisfaction was not statistically different among patient’s characteristics at p
Ảnh hưởng hạn chế tài chính đến quyết định nắm giữ tiền mặt của các doanh nghiệp niêm yết tại Việt Nam
Authors: Hà Phạm , Trân Phan Đinh Quế 
Published: April 2021

Trong hoạt động sản xuất kinh doanh, nguồn vốn lưu động có vai trò quan trọng nhằm bảo đảm sự vận hành liên tục của doanh nghiệp, trong đó việc nắm giữ tiền mặt có ý nghĩa sống còn với các doanh nghiệp khi mà nhu cầu
nắm giữ tiền mặt giúp các doanh nghiêp đáp ứng kịp thời các dự án đầu tư cũng như tạo thuận lợi cho các hoạt động khác của doanh nghiệp. Tuy nhiên việc nắm giữ tiền mặt của các doanh nghiệp có tiềm lực dồi dào sẽ dễ dàng hơn so với các doanh nghiệp gặp khó khăn trong các hoạt động kinh doanh và bị giới hạn nguồn vốn. Nghiên cứu này tìm hiểu sự ảnh hưởng của hạn chế tài chính đến các quyết định nắm giữ tiền mặt của các doanh nghiệp. Quyết định nắm giữ tiền mặt của các doanh nghiệp niêm yết trên các sàn chứng khoán Việt Nam có sự khác biệt ra sao khi doanh nghiệp niêm yết trên hai sàn giao dịch chứng khoán khác nhau. Với dữ liệu là 102 doanh nghiệp niêm yết trên hai sàn chứng khoán Việt Nam và sử dụng phương pháp định lượng, nghiên cứu đã tìm ra được có mối quan hệ đồng biến giữa hạn chế tài chính và nắm giữ tiền mặt đồng thời cho thấy sự nắm giữ tiền mặt vượt trội tại sàn Hồ Chí Minh. Từ kết quả nghiên cứu này có thể giúp các doanh nghiệp tại Việt Nam có được biện pháp vượt qua khó khăn về tài chính trong hiện tại và tương lai.
Hành vi lãnh đạo ảnh hưởng đến sự hài lòng và hiệu suất công việc của nhân viên y tế các bệnh viện công tại Thành phố Hồ Chí Minh
Authors: Pháp Phan Cảnh , Dũng Huỳnh Chí , Khương Mai Ngọc 
Published: April 2021

Nghiên cứu định lượng với 938 phiếu khảo sát được lấy từ nhân viên y tế của 5 bệnh viện công lập trên địa bàn TP. Hồ Chí Minh nhằm tìm ra các nhóm hành vi lãnh đạo có tác động có ý nghĩa đến sự hài lòng và hiệu suất công việc của đội ngũ nhân viên y tế trong các bệnh viện công. Phần mềm SmartPLS được sử dụng để kiểm định thang đo và các giả thuyết của mô hình nghiên cứu. Kết quả nghiên cứu chỉ ra có 2 yếu tố thuộc phong cách lãnh đạo trao đổi; thưởng theo thành tích và quản lý ngoại lệ chủ động và 1 yếu tố thuộc phong cách lãnh đạo chuyển hóa; ảnh hưởng lý tưởng thuộc tính tác động có ý nghĩa đến sự hài lòng và hiệu suất làm việc của nhân viên y tế tại các bệnh viện công lập. Nghiên cứu cũng xác định có sự tác động tích cực của sự hài lòng đến hiệu suất làm việc.
Từ khóa: chuyển hóa, hài lòng, hiệu suất, trao đổi
Study of chemical-based induced bacterial ghost applied in vaccine production
Authors: Thanh Doan Duy , Hanh Tran Xuan 
Published: April 2021

Introduction: Bacterial ghosts (BGs), known as the empty cell envelope of gram-negative bacteria lacking cytoplasmic content yet retaining all unaltered morphological and structural features of their living counterparts, are widely studied and used as the platform for the production of the vaccines as well as the transporting drug and gene delivery. However, the study related to the creation of BGs based on gene expression is still limited because of the difference in cell wall structure between microorganisms. Therefore, in the current study, for the aims to determine chemicals combination and minimum inhibition concentration (MIC) to optimize BGs production.
Material and method: Salmonella choleraesuis strain was collected from NAVETCO company. The study used critical concentrations from chemical combination to convert salmonella cells to BGs. Chemicals combination and MIC, temperature, shaking speed were optimized using Plakett- Burman matrix and response surface methodology. Cell structure was determined by using a scanning electron microscope, experimental mice were vaccinated and challenged with virulence to determine immune responses of bacterial ghost.
Results: The appropriate chemicals for the production of BGs biomass were NaOH 3.125 mg/ml; SDS 1.15 mg/ml, H2O2 8.79 µl/ml, ethanol. The observation of morphology, BGs have remained the structure and shape, which were like the living microbial cells.
Conclusions: The conditions of BGs production have been identified to produce large amounts of bacterial ghost biomass to further application in vaccine production and pharma.
In silico analysis of hypermethylation in CpGislands of UCHL1 gene’s promoter in nasopharyngeal carcinoma
Authors: Thuan Lao Duc , Hue Thieu Hong , Nam Hoang Van , Danh Nguyen Hoang , Thuy Le Huyen Ai , Kha Ngo Dong , Tuan Nguyen Hoang Anh 
Published: April 2021

Background and Objective: The methylation of Ubiquitin C-Terminal Hydrolase L1 (UCHL1) gene has been reported in many human cancers including nasopharyngeal carcinoma (NPC). In Vietnam, the methylation of
UCHL1 gene’s promoter in NPC has not been demonstrated yet. In this study, a systematic literature revision was carried out to summarize the current evidences about the frequencies of UCHL-1 gene’s promoter methylation in
NPC for further application in Vietnamese population.
Methods: A systematic literature analysis was conducted based on the comprehensive studies. Moreover, many bioinformatic tools such as Methprimer, TFsearch, IDT OligoAnalyzer 3.1 were used to predict the CpG
islands, transcriptional factors, and to pick up the MSP (Methylation-Specific PCR) primers.
Results: Total of three previous studies were summarized and accessed for eligibility from literature research. As the results, the average weight methylated frequencies were 72.4% and 13.0% for NPC and non-cancerous
samples, respectively. The significant association between UCHL-1 promoter methylation and NPC with the OR of 10.459 (95% CI = 4.915 – 22.254, p < 0.001) and RR of 4.117 (95% CI = 1.958 – 6.645, p < 0.0001) based on the
random effects model, was observed. Moreover, we were successful in predicting the CpG islands as well as identifying transcriptional factor binding sites which served as “hot spot” for ideal primer pick up and located in gene promoter.
Conclusion: The methylation of UCHL-1 gene promoter was significantly associated and contributed to NPC developmentin which it could be further applied in evaluation of UCHL-1 gene promoter status in Vietnamese population.
Research antioxidant activity of chitooligosacchride by UV-VIS absorption spectrocopy
Authors: Hoai Bui Van , Nghiep Ngo Dai , Quang Dao An , Phuong Nguyen Thi Nam 
Published: April 2021

Chitosan with 80% degree of deacetylation was hydrolyzed by cellulase of Trichoderma viride to prepare chitooligosaccharides (COSs) by the fractionation of the COSs with ultrafiltration membrane. The antioxidant
activities of the COSs were clarified in this study by reducing power and free radical scavenging ability assay by UV-VIS absorption spectrum. The results show that the COS 1 (10,000-5,000 Da), COS 2 (5,000-3,000 Da), COS 3 (3,000-1,000 Da) and COS 4 (less than1,000 Da) segments have antioxidant properties.The antioxidant activitives of the COSs increased with the increment of concentration, and they also depended on molecular weight.
Rational protein design for enhancing thermal stability of industrial enzymes
Authors: Tuan Le Quang Anh 
Published: April 2021

Enzymes possessing many excellent properties such as high selectivity, consuming less energy, and producing less side products or waste have been widely applied as biocatalysts in pharmaceutical production and many industries such as biofuel, biomaterials, biosensor, food, and environmental treatment. Although enzymes have shown its potential as biocatalysts for many industrial applications, natural enzymes were not originated for manufacturing process which requires harsh reaction conditions such as high temperature, alkaline pH, and organics solvents. It was reported that reduction of final conversion of several enzymatic reactions was declined at high temperature. Protein engineering to improve the enzymes’ thermostability is crucial to extend the use of the industrial enzymes and maximize effectiveness of the enzyme-based procesess. Various industrial enzymes with improved thermostability were produced through rational protein engineering using different strategies. This review
is not aimed to cover all successful rational protein engineering studies. The review focuses on some effective strategies which have widely used to increase the thermostability of several industrial enzymes through introduction of disulfide bonds and introduction of proline.
Screening of endophytes from rubber trees (hevea brasiliensis) for biological control of Corticium salmonicolor
Authors: Minh Nguyen Van , Phuc Mai Huu , Linh Duong Nhat , Ni Tran Thi A , Duc Tran Kien , Nghia Nguyen Anh 
Published: April 2021

28 leaves and living-tissue samples of rubber tree (Hevea brasiliensis) were collected from Ho Chi Minh City, Binh Phuoc province and Binh Duong province (Viet Nam). We isolated and screened endophytes that have potential application as agents for biocontrol of Corticium salmonicolor, the agent of Pink Disease in rubber trees. As a result, 21 strains of endophytic bacteria and 14 strains of endophytic fungi were isolated. Antagonistic activity of the endophytes towards C. salmonicolor was checked by using a dual culture. Testing results showed that: T9, T15 and T16 strains have inhibited C. salmonicolor. T9 and T16 strains showed result that 100% of inhibiting C. salmonicolor at the concentration of 1:1. In the test of ability to kill C. salmonicolor, T9 and T16 strains showed that they could kill C. salmonicolor
after 3 sprays of bacterial filtrate. T9 and T6 strains, which were identified by biochemical methods, have similar characteristics to Bacillus thuringiensis.
Meta-analysis: Assocation between promoter hypermethylation of DAPK (Death-Associated Protein Kinase) and cervical cancer
Authors: Thuan Lao Duc , Phuong Truong Kim 
Published: April 2021

Purpose: Death-associated protein kinase (DAPK or DAPK1) is an important tumor suppressor protein that involved in the regulation of cell activities. The aberrant methylation of DAPK promoter has been reported in patients with cervical cancer. However, the association between of DAPK1 and cervical cancer was not always unification, in previous studies. Therefore, in current study, a meta-analysis was performed for association of between DAPK gene’s promoter hypermethylated and cervical cancer.
Methods: A systematic literature analysis was conducted based on the previous studies published in PubMed, PubMed Central (NCBI), Google by using following keywords: cervical cancer, cervical carcinoma, Methylation, by the end of January, 2018. The association between DAPK promoter methylation and cervical cancer was evaluated by odds ratio (ORs) and 95% confidence intervals (CI). To evaluate the potential sources of heterogeneity, the meta-regression analysis and subgroup analysis were conducted.
Results: A total of 21 case-control studies which relevant to the association between DAPK1 gene’s promoter methylation frequency and cervical cancer, that including 1600 cancer cases and 1011 control cases (non-cancerous cases). The analysis results indicated that the characteristic of candidate gene’s promoter methylation increased the cervical cancer risk through the calculation of OR value (OR = 21.25; 95% CI = 8.73 – 52.97; p < 0.001; Random effect model). The association between DAPK1 gene’s promoter hypermethylation was confirmed in all the subgroups analyses, including materials and assays methods, ethnicity. Furthermore, this association is higher in cervical squamous cell carcinoma than cervical adenocarcinoma and is a characteristic of late-stage disease.
Conclusion: The hypermethylated DAPK1 gene’s promoter was also one of etiological factor, lead to the cervical tumorigenesis.
Prevention Program Regarding Falls among Older Adults at Geriatrics Homes
Authors: Mohamed Asmaa T. , Abd Elltef Mona A. B. , Miky Shimaa F. 
Published: April 2021

Context: Older adults are vulnerable to falls that result in injury and disability, making fall prevention a national priority.
Aim: This study aimed to evaluate the effect of a fall prevention program on older adults' knowledge, practices, and elder wellbeing regarding falls.
Methods: A quasi-experimental (single group pre/post-test design) was utilized to achieve the aim of this study. Four geriatric homes at the North district, Cairo governorate were included in the study. The systematic random sample composed of 50 older adults were included in this study. The pre-designed interviewing questionnaire was utilized to collect data regarding socio-demographic characteristics to assess age, sex, marital status of the older adult, and to assess the presence of chronic illness, medication, frequency of falling, and hospitalization. This questionnaire also assesses the knowledge of older adults regarding meaning, causes, protective measures, complications, and a safe environment. Besides, it assesses the reported practices of older adults regarding their health maintenance measures, nutrition, physical activity, and safe home environment. Older adult wellbeing scales developed to assess older adult physical, social, and psychological wellbeing. An environmental safety checklist used to assess the safety of the geriatric home environment.
Results: Revealed that more than two-thirds of older adults aged ≥ 75 years more than half of them experienced falling two times during the past two years, there was a highly statistically significant difference in older adults' total knowledge pre and post prevention program implementation P<0.001. Moreover, there was a highly statistically significant difference between total older adult reported practices pre and post prevention program implementation P<0.001. There was statistically significant improvement related to the physical, social, and psychological wellbeing of older adult pre and post-program implementation. There was a statistically significant correlation between the older adult educational level and their knowledge and practices (p<0.05).
Conclusion Application of the prevention program has a positive effect on the studied older adults' knowledge, reported practices, and their wellbeing regarding fall prevention at geriatric homes. The current study recommended that prevention programs should be applied in all geriatric homes to prevent and control falls among older adults.
Effect of Psycho-Educational Program on Psychological Distress and Post-Traumatic Stress Disorder among Stroke Survivors' Patients
Authors: Barakat Mona M. , Mostafa Hend A. 
Published: April 2021

Context: A stroke is a brain attack, and a major global health problem not merely affects a person physically but also emotionally. Psychosocial well-being is frequently threatened following a stroke. The improvement of the psychological status of stroke patients is essential to stroke management and recovery.
Aim: The study aimed to evaluate the effect of the psychoeducational program on psychological distress and posttraumatic stress disorder among stroke survivors' patients.
Methods: A quasi-experimental study design (one group pre/posttest) was utilized to achieve the aim of the study in the neurology department at Benha University Hospital at Benha City, Kaluobia Governorate. A convenient sample of 40 stroke survivor's patients was included in the study as a single study group. Three tools were utilized for data collection, structured interview questionnaire, Hospital Anxiety, and Depression Scale, and Post Traumatic Stress Disorder Scale.
Results: Reveals that there was a highly statistically significant reduction in the severity of total anxiety and depression and also total posttraumatic stress disorder post-program implementation than before. Also, there was a highly statistically significant positive correlation between total posttraumatic stress, total anxiety, and total depression among studied patients pre and post-program implementation at p-value <0.001.
Conclusion: Psycho-educational program had a positive effect on reducing psychological distress and posttraumatic stress disorder among stroke survivors' patients. The study recommended that psychological nursing intervention should be continuously integrated as a part of routine nursing care provided for stroke survivors' patients in the neurology and rehabilitation unit.
PENINGKATAN PRESTASI BELAJAR MATEMATIKA SISWA MELALUI LEMBAR KERJA SISWA DENGAN PENDEKATAN OPEN ENDED SMP NEGERI 2 CEPER KLATEN
Authors: Putra Aji Permana 
Published: April 2021

The purpose of this class action research is to (1) improve students' mathematics learning achievement through learning with the help of worksheet open ended approach in class VII F SMPN 2 Ceper, Ceper District, Klaten Regency 2017/2018 Academic Year. (2) Describe how to overcome the constraints of applying learning with the help of worksheet open ended approach to improve mathematics learning achievement of class VII F SMPN 2 Ceper. Based on the results of the study it can be concluded: (1) The application of the learning with the help of worksheet open ended approach can improve the learning achievement of grade VII F SMPN 2 Ceper, which is indicated by: students of class VII F as many as 32 students have increased learning achievement that is before action only 53.1% of students study completely, after the action becomes 100%. How to overcome constraints, namely the teacher must be skilled in applying learning with the help of worksheet open ended approach is: a) reviewing the concepts and basic competencies that students will learn, b) forming heterogeneous study groups both in terms of ability, gender, religion, tribes etc., c) prepare everything about learning as well as possible so that when learning runs smoothly, d) minimize the number of group members so that learning takes place effectively with no passive group members or playing alone during group discussions, e) giving gifts at the best group presentations.
Implementasi Model Pembelajaran Team Game Tournament (TGT) Untuk Meningkatkan Hasil Belajar Siswa
Authors: Putri Prihastini Oktasari 
Published: April 2021

This study aims to: (1) find out how to apply the Team Game Tournament (TGT) type cooperative model in learning mathematics. (2) determine whether using the cooperative model type Team Game Tournament (TGT) can improve student mathematics learning outcomes. The type of research used is Classroom Action Research (CAR). The sample in this study were all grade V students of SD Negeri 1 Plumbon in the academic year 2019/2020 as many as 24 students. The instruments used in this study were observation, documentation and student achievement tests
Based on the results of the study, it was concluded that: the use of a cooperative model type Team Game Tournament (TGT) can improve student learning outcomes in mathematics class V SD Negeri 1 Plumbon. This can be shown in the final cycle test results obtained a significant increase in value, meaning that the learning process of mathematics using the cooperative model type Team Game Tournament (TGT), the class average value has increased with the results in the pre-cycle of 51.625; cycle I amounted to 63.75 and cycle II amounted to 75.625. With the percentage of completeness in the pre-cycle of 29.17%, the first cycle of 50% and the second cycle of 79.17%.