bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Drug Regimens Containing Integrase Inhibitor Show Good Efficacy and Safety in Treatment-Naive Patients With HIV-1: A Bayesian Analysis
Authors: Zhang Ke , Zhang Yang , Liu Xinchao , Li Aixin , Gao Meixia , Hou Jianhua , Guo Chunxiang , Zhang Tong , Wu Hao , Chen Guanzhi , Huang Xiaojie 
Published: July 2021

Introduction:The extensive utilisation of antiretroviral therapy has greatly improved the survival rates of those infected with human immunodeficiency virus (HIV). The objective of this study was to compare 3-drug regimens containing non-nucleoside reverse transcriptase inhibitor with 3-drug regimens containing integrase inhibitor (INI) regarding efficacy and safety in treatment-naive HIV-1-infected adults at 48 and 96 weeks, respectively.Methods:This study was a network meta-analysis using a Bayesian methodology. On January 8, 2020, we searched databases and other sources for randomized controlled trials conducted in treatment-naive HIV-1 adults and compared multiple 3-drug antiretroviral regimens containing INI, efavirenz (EFV), or rilpivirine (RPV). We extracted data on the following outcomes: virologic suppression, CD4+cell recovery, discontinuations, deaths, adverse events, serious adverse events, deaths related to study drugs, and drug-related adverse events. We conducted calculations within a Bayesian framework using R software.Results:The network contained 15 randomized controlled trials including 9,745 patients. For efficacy outcomes, regimens containing INI, especially dolutegravir (DTG), were generally superior to other regimens. For virologic suppression at 48 weeks, odds ratios (95% credible intervals) were 0.6 (0.43, 0.82) for EFV+ tenofovir disoproxil fumarate (TDF)+emtricitabine (FTC) versus DTG+ abacavir+ lamivudine (3TC) and 0.52 (0.36, 0.75) for EFV+TDF+FTC vs. DTG+TDF+FTC/3TC. For safety outcomes, regimens containing INI tended to be safer relative to regimens without INI. Outcomes associated with death were unsuitable for network meta-analysis due to low event rates.Conclusion:3-drug regimens containing INI demonstrate better efficacy and safety than those containing RPV or EFV.
Mediators in Psychological Treatments for Anxiety and Depression in Adolescents and Young People: A Protocol of a Systematic Review
Authors: Conejo-Cerón Sonia , Taubner Svenja , Heinonen Erkki , Adler Asta , Barkauskiene Rasa , Di Giacomo Dina , Ioannou Yianna , Mestre Jose M. , Henriques Margarida Rangel , Mota Catarina Pinheiro , Protić Sonja , Raleva Marija , Vieira Filipa Mucha , Røssberg Jan Ivar , Sales Célia M. D. , Saliba Andrea , Schmidt Stefanie J. , Perdih Tjaša Stepišnik , Ulberg Randi , Volkert Jana , Moreno-Peral Patricia 
Published: July 2021

IntroductionAnxiety and depressive disorders are a significant problem that starts in childhood or adolescence and should be addressed early to avoid chronic mental conditions. There is strong evidence to demonstrate that psychological treatments are effective for these disorders, however, little is known on mediators and mechanisms of change of psychological treatment in adolescents and young adults. Understanding the pathways through which psychological treatments operate will facilitate more effective treatments.AimWe aim to conduct a systematic review, exploring the available evidence on mediators of psychological treatments for anxiety and depression in adolescents and young adults.MethodsA systematic search has been performed on PubMed and PsycINFO databases to identify studies from inception to 23rd February 2020. Eligible studies include randomized controlled trials and trials (quasi-experimental) designs that have enrolled adolescents and young adults presenting with depression and/or anxiety and that have examined mediators of psychological treatments. A group of 20 reviewers from the COST-Action TREATme (CA16102) divided into 10 pairs independently screen studies for inclusion, extract information from the included studies, and assess the methodological quality of the included studies and the requirements for mediators. The methodological quality will be assessed by The Mixed Methods Appraisal Tool. Extracted data from the included studies will be collected and presented using a narrative approach.DiscussionThis systematic review will summarize and provide a comprehensive overview of the current evidence on mediators of psychological treatments for anxiety and depression for adolescents and young adults. Results will allow the identification of strategies to optimize intervention to enhance clinical outcomes.Ethics and disseminationEthics approval is not required. Findings from this systematic review will be published in a peer-reviewed journal and disseminated at conferences and meetings. PROSPERO registration number: CRD42021234641.
Family Care, Economic Stress, and Depressive Symptoms Among Chinese Adults During the COVID-19 Outbreak: Difference by Urban and Rural Areas
Authors: Liu Chengbin , Zhang Liyuan , Ahmed Farooq , Shahid Muhammad , Wang Xiaohua , Wang Yiqing , Wang Junlan , Guo Jing 
Published: July 2021

Background: Although several studies have shown an association of family care with a high level of depressive symptoms, the relationship between them remains indistinguishable.Objective: This study aims to examine the associations between family care, economic stress, and depressive symptoms among Chinese adults in urban and rural areas during the COVID-19 outbreak.Methods: Based on cross-sectional data collected through online surveys from February 1st to 10th 2020 in China the present study recruited 2,858 adults. It used multiple linear regression to examine the association between family care and depressive symptoms, while economic stress was examined as moderators on the above relationship.Results: The results showed that caring for both the elderly and children was significantly associated with higher depressive symptoms compared with non-caregivers (B = 2.584, 95%CI: 1.254, 3.915), and a similar result was also found in urban areas. Also, caring for the elderly only was also had a higher level of depressive symptoms than non-caregivers in rural areas (B = 3.135, 95%CI: 0.745, 5.525). Meeting the care needs was significantly associated with lower depressive symptoms compared with unmet care needs, while for rural caregivers, the results were not significant. Besides, economic stress strengthened the effect of family care needs on depressive symptoms for sandwich-generation caregivers who provide care to both the elderly and children (B = 0.605, 95%CI: 0.077, 1.134). While in rural areas, the moderation effects of economic stress were only found for elderly caregivers (B = 1.106, 95%CI: 0.178, 2.035).Conclusion: These findings suggest that we should pay more attention to the family caregiver's mental health during the COVID-19 outbreak. In addition, more effective policies should be developed to provide financial support for family caregivers, especially for sandwich-generation caregivers and rural elderly caregivers.
Case Report: Iatrogenic Dental Progress of Phantom Bite Syndrome: Rare Cases With the Comorbidity of Psychosis
Authors: Watanabe Motoko , Hong Chaoli , Liu Zhenyan , Takao Chihiro , Suga Takayuki , Tu Trang Thi Huyen , Yoshikawa Tatsuya , Takenoshita Miho , Sato Yusuke , Higashihori Norihisa , Moriyama Keiji , Motomura Haruhiko , Toyofuku Akira 
Published: July 2021

Introduction: Phantom bite syndrome (PBS) is considered as the preoccupation with dental occlusion and the continual inability to adapt to changed occlusion. These patients constantly demand occlusal corrections and undergo extensive and excessive dental treatments. We present three cases with PBS-suspected iatrogenic concerns and the attribution to underlying psychosis.Case Presentation: A 70-year-old female demanded orthodontic retreatment and complained of tightness and cramped sensation of teeth in the oral cavity, uncomfortable occlusion, and pain in her neck and legs that she was convinced was induced by orthodontic treatment. However, even earlier than the orthodontic treatment, she had kept doctor shopping for over 35 years, not merely dentists but also psychiatrists, neurologists, and so on; she was diagnosed with bipolar disorder. A 48-year-old female complained of malaligned improper occlusion and demanded occlusal adjustment. These symptoms occurred in the absence of a dental trigger and were worsened by orthodontic treatment. She underwent psychiatric treatment for 15 years with a diagnosis of bipolar disorder. A 38-year-old female, who had a history of schizophrenia for over 20 years, complained of occlusal discomfort and revisited with a complaint of abnormal occlusion due to excessive dental procedures. In the last two cases, requests for dental procedures had reduced owing to the collaboration between the psychiatrists and dentists. All the cases first visited our clinic following a succession of dental visits. They were strongly convinced that occlusal correction was the only solution to their symptoms, including the symptoms of discomfort in other body parts. Their misleading perceptions were uncorrectable, and repeated dental treatments exacerbated their complaints. Moreover, the dentists overlooked the psychotic histories of the patients, while the comorbid psychosis resulted in a strict demand for dental treatment by the patients.Conclusions: The presented PBS cases with psychosis suggest that repeated dental treatments and comorbid psychosis exacerbate PBS. Moreover, their persistent demands reflecting comorbid psychosis led dentists to perform numerous procedures. Early detection of underlying psychosis and the prompt collaboration between psychiatrists and dentists are integral to help prevent complications in PBS cases with psychosis.
Establishing a Standardized Measure of Quality in Pediatric Liver Surgery: Definition and Validation of Textbook Outcome With Associated Predictors
Authors: Fuchs Juri , Hoffmann Katrin , Murtha-Lemekhova Anastasia , Kessler Markus , Günther Patrick , Frongia Giovanni , Probst Pascal , Mehrabi Arianeb 
Published: July 2021

Purpose: To establish comparable reporting of surgical results in pediatric liver surgery, the recently introduced composite outcome measures Textbook Outcome (TO) and Comprehensive Complication Index (CCI) are applied and validated in a pediatric surgery context for the first time. In a representative cohort of pediatric patients undergoing liver resection, predictive factors for TO and CCI are investigated, and outcomes are compared to available literature on surgical outcomes of pediatric liver resection.Methods: All liver resections for patients under 21 years of age performed at the Department of General, Visceral, Transplantation and Pediatric Surgery of the University of Heidelberg between 2009 and 2020 were included in the analysis. Criteria for TO were defined prior to the analysis. Univariate and Multivariate regression was applied to identify factors associated with TO and CCI.Results: Fifty-three pediatric patients underwent liver resections during the observation period. No 30- or 90-day mortality occurred. Twenty-three patients (43.4%) had a TO. CCI and TO showed highly significant correlation (b = −30.33, 95% CI [−37.44; −23.22], p &lt; 0.001). Multivariate analyses revealed significant association between intraoperative blood loss (adjusted for circulating blood volume) and CCI (b = 0.70, 95%CI [0.22; 1.32], p = 0.008) and failure to achieve TO (OR = 0.85, 95%CI [0.69; 0.97], p = 0.048).Conclusion: TO and CCI are suited outcome measures in pediatric surgical studies and offer objective comparability of results. Their application in clinical studies will be a major step forward to establish evidence-based therapies in pediatric surgery. Systematic utilization of TO and CCI can aid in generating comparable studies on surgical techniques and outcomes in pediatric liver resection.
MÉTODO ALTERNATIVO PARA A REDUÇÃO DO GRAU DOS POLINÔMIOS PALINDRÔMICOS DE COM COEFICIENTES REAIS
Authors: Célia Bueno da Fonseca Regina , A. de Freitas Vaz Duelci , César Saavedra Vásquez Julio 
Published: July 2021

O comportamento dos zeros dos polinômios algébricos ´é uma das sub´áreas cl´ássicas da Análise. Tal assunto ´é muito abordado na Matem´ática e atualmente as funções polinomiais são temas de muita investiga¸ção, tanto na área computacional, quanto na teórica. O comportamento dos zeros de polinômios palindrômicos no c´ırculo unitário ´ é motivo de pesquisa na literatura [1], [2] e [3]. Nos polinˆômios palindrômicos P2n (z), n inteiro, de grau par, sabe-se que podem ser expressos P2n (z) = zn Q(z + 1/z) onde Q ´é um polinômio de grau n, de tal forma que a partir das raízes de Q obtemos as ra´ızes de P2n (z). Keith Conrad1 aborda um procedimento para tal prop´ósito. Neste trabalho apresentamos um m´étodo alternativo com a mesma finalidade.
1Symmetric Polynomials. Dispon´ıvel em: https : //citeseerx.ist.psu.edu/viewdoc/summary?doi =10.1.1.299.5987&rank = 1
THE CONVERGENCE OF BIOMEDICAL AND TECHNICAL ASPECTS OF ELECTROMAGNETIC SAFETY
Authors: МАСЛОВ М.Ю. , СПОДОБАЕВ Ю.М. 
Published: July 2021

Эволюция инфотелекоммуникаций, демонстрирующая стремительные темпы перехода к высокотехнологичным системам, сопровождается глубоким взаимным проникновением технологий - конвергенцией. Показано, что широкое использование беспроводных систем связи вызвало насыщение окружающей среды технологическими электромагнитными полями (ЭМП), а это, в свою очередь, актуализировало проблему защиты населения. Подчеркивается, что такая коренная перестройка привела к равномерному плотному размещению излучающих фрагментов сетей на селитебных территориях. Изменившиеся параметры излучаемых полей требуют пересмотра нормативно-методического обеспечения электромагнитной безопасности. Фрагментарный структурный, функциональный и параметрический анализ проблемы защиты населения от технологических полей выявил неопределенность в толковании реальных ситуаций, уязвимость, слабость и необоснованность методологической основы санитарно-гигиенических подходов на всех этапах электромагнитной экспертизы излучающих фрагментов сетевых технологий. Отмечается, что следствием этого являются недоверие со стороны специалистов и населения к системе санитарно-гигиенического контроля и в целом к безопасности современных технологий, растущая социальная напряженность и радиофобия. В качестве основы для решения проблем защиты населения предлагается субъективные методы и средства мониторинга ЭМП перенести в область информационных технологий.
The evolution of infotelecommunications, demonstrating the rapid pace of transition to high-tech systems, is accompanied by deep mutual penetration of technologies - convergence. It is shown that the widespread use of wireless communication systems has led to the saturation of the environment with technological electromagnetic fields (EMF), and this, in turn, has actualized the problem of protecting the population. It is emphasized that such a radical restructuring has led to a uniform dense distribution of radiating network fragments in residential areas. The changed parameters of the radiated fields require a revision of the regulatory and methodological support of electromagnetic safety. A fragmentary structural, functional, and parametric analysis of the problem of protecting the population from technological fields revealed uncertainty in the interpretation of real situations, vulnerability, weakness, and groundlessness of the methodological basis of sanitary and hygienic approaches at all stages of electromagnetic examination of emitting fragments of network technologies. It is noted that the consequence of this is the distrust of specialists and the population to the system of sanitary and hygienic control and, in general, to the safety of modern technologies, growing social tension, and radiophobia. As a basis for solving the problems of protecting the population, it is proposed to transfer subjective methods and means of monitoring EMF to the field of information technologies.
DEVELOPMENT OF A SOFTWARE COMPLEX FOR INTELLIGENT TUNING OF OPERATING FREQUENCIES FOR COGNITIVE RADIO SYSTEMS
Authors: КАНДАУРОВА Е.О. , ЧИРОВ Д.С. 
Published: July 2021

Представлено описание разработанных программных модулей интеллектуальной перестройки рабочих частот для системы когнитивного радио, в которых применяется ранее предложенный алгоритм анализа использования радиочастотного спектра. Также разработаны программные модули для взаимодействия с программно-определяемыми радиосистемами, такими как LimeSDR. Экспериментально показано, что использование алгоритма предсказания занятости частотных каналов позволяет сократить время оперативного сканирования спектра.
A description of the developed software modules for intelligent tuning of operating frequencies for the cognitive radio system is presented. These software modules use the previously proposed algorithm of RF spectrum utilization analysis. Also, software modules have been developed for interacting with software-defined radio such as LimeSDR. Experimental studies have shown that the use of an algorithm for predicting the occupancy of frequency channels allows reducing the time of operational scanning of the spectrum.
ASSESSMENT OF RUSSIA'S REAL NEEDS FOR MOBILE SATELLITE COMMUNICATIONS SERVICES
Authors: АЛЕШИН В.С. , ДОГАЕВ С.Г. 
Published: July 2021

Приведена количественная оценка реальных потребностей Российской Федерации в услугах подвижной спутниковой связи на период 2021-2030 гг. Оценка выполнялась путем прямого подсчета численности потенциальных потребителей услуг в разных сферах народного хозяйства России, включая ее Арктический регион и Северный морской путь, с учетом возможностей реализации альтернативных спутниковым вариантов предоставления этих услуг.
A quantitative assessment of the real needs of the Russian Federation for mobile satellite communication services in 2021-2030 is presented. The assessment was carried out by directly calculating the number of potential consumers of services in various areas of the Russian economy, including its Arctic region and the Northern Sea Route, taking into account the possibilities of implementing alternative economic options for providing these services.
DIRECTIONS OF DEVELOPMENT OF REGIONAL NETWORKS OF THE DVB-T2 STANDARD IN RUSSIA
Authors: КАРЯКИН В.Л. 
Published: July 2021

Приведены основные и приоритетные направления стратегии развития телерадиовещания до 2025г. Дан анализ проблем развития в России региональных сетей стандарта DVB-T2 и пути их решения с применением отечественных иннова -ционных технологий для обеспечения устойчивого и бесперебойного телерадиовещания. Предлагается метод реализации региональной сети SFN вещания с наземными волоконно-оптическим каналами связи, защищенный патентом РФ.
The main and priority directions of the TV and radiobroadcasting development strategy up to 2025 are presented. The analysis of problems in the development of regional DVB-T2 networks in Russia and ways of their solution using domestic innovative technologies to ensure sustainable and uninterrupted TV and radio broadcasting is given. The method of implementation of regional SFN broadcasting network with terrestrial fiber-optic communication channels, protected by the patent of the Russian Federation, is proposed.
APPLICATION OF TELECOMMUNICATION SYSTEMS IN THE PREPARATION OF ENSEMBLE MUSICAL COMPOSITIONS
Authors: ЕПИФАНОВА Е.С. 
Published: July 2021

Показано, что при классических методах исполнения ансамблевых произведений спутниковые системы связи для взаимодействия музыкантов с дирижером применяться не могут, поскольку не соответствуют требованиям по задержке распространения сигнала, а применение действующих систем связи на базе интернет-протокола (IP) ограничено. Предложены технология и стандартное оборудование, позволяющие использовать мобильные интернет-каналы для обеспечения слитности звучания музыкальных произведений при ансамблевом исполнении в условиях дистанцирования музыкантов.
It is shown that with classical methods of performing ensemble musical compositions, satellite systems for communication of musicians and conductor cannot be used, since they do not meet the requirements for signal propagation delay. The technology and standard equipment that allow the use of mobile Internet channels to ensure the fusion of musical compositions during remote ensemble performance are proposed.
DIGITAL TERRESTRIAL BROADCASTING: FEATURES OF IMPLEMENTATION AND ISSUES OF USING RADIO BROADCASTING
Authors: ЛАШКЕВИЧ А.В. 
Published: July 2021

В статье проанализированы основные характеристики существующих систем цифрового звукового и мультимедийного радиовещания, преимущества цифрового радиовещания как технологии передачи звуковой и мультимедийной информации, особенности использования различных диапазонов частот, влияние социальных, технико-экономических факторов и географических особенностей на технические требования к сетям радиовещания. Рассмотрены вопросы организации высококачественного радиовещания, способного привлечь аудиторию в условиях современного развития технологий. Определены основные задачи в области производства приемного оборудования для цифрового радиовещания.
The article analyzes the main features of existing digital sound and multimedia broadcasting, advantages of digital radio as a technology for transmitting sound and multimedia information, benefits of different frequency ranges for digital radio, the influence of social, technical, and economic factors, and geographical characteristics on the technical requirements for broadcasting networks. The issues of the organization of high-quality radio broadcasting capable to attract an audience in conditions of the modern development of technologies are considered. The main tasks in the field of digital radio receiving equipment production are determined.
A METHOD FOR SIZING DIGITAL CLUSTERS OF ULTRA-LOW LATENCY NETWORKS
Authors: ЧИСТОВА Н.А. , ПАРАМОНОВ А.И. , ВЫБОРНОВА А.И. , КУЧЕРЯВЫЙ А.Е. 
Published: July 2021

Рассматривается метод выбора размеров цифровых кластеров в сети с ультрамалыми задержками с учетом длин соединительных линий. Расчет линейных размеров только на базе требований к задержке не учитывает особенностей прокладки трасс линий связи, длина которых больше полученных оценок, что отрицательно влияет на временные характеристики. Предлагается метод, учитывающий особенности прокладки линий связи на основе оценок фрактальной размерности сети дорог. Метод может быть использован в задачах планирования и проектирования сетей с ультрамалыми задержками.
The paper proposes a method for sizing digital clusters in ultra-low latency networks, taking into account the lengths of connecting lines. Calculation of linear dimensions only on the basis of delay requirements does not take into account the peculiarities of laying communication lines, the length of which is greater than the obtained estimates, which negatively affects the temporal characteristics. The paper proposes a method thattakesintoaccountthepeculiaritiesoflayingcommunication lines based on estimates of the fractal dimension of the road network. The proposed method can be used in the planning and design of ultra-low latency networks.