bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical analysis of different extracts of Pinda concanensis and Heracelum grande
Authors: Bidve Sucheta , Auti Sanjay 
Published: December 2021

Aromatic plants are a reservoir of secondary metabolites that are responsible for the plants' medicinal efficacy and a major source of aromatic compounds and essential oils. Now a day, there is a renewed interest in the plant kingdom in the search for novel bioactive and fragrance compounds as demands for herbal products are increasing enormously. In the present study two endemic plants, Pinda concanensis and Heracelum grande from Western Ghats were analyzed for secondary metabolites by using different plant parts (roots, leaves, and seeds) and by using range of solvent from polar to non-polar. Glycosides, terpenoids, tannins, flavonoids, saponins, steroids, and alkaloids were found in methanolic extracts of Pinda concanensis root, leaf, and seeds and methanolic extracts of seeds of Heracelum grande. While extracts of chloroform and petroleum ether exhibits presence of some of them. Obtained results show the importance of both the plants as an important source of biologically active molecules for pharmaceuticals and cosmetic industries.
Keywords: Phytochemical screening, secondary metabolites, biologically active compounds.
Assistance of Gut Microbiota in Depression
Authors: Reji Reeja T , Ravi Krishna , Sambath Kumar R. 
Published: December 2021

The association between gut microbiota and mental health is a relatively new research topic that has gained traction in recent years. Depression is a serious mental illness and a leading cause of disability, morbidity, and mortality worldwide. Based on the WHO reports, there are approximately 350 million people affected by depression globally. Currently available treatments can temporarily alleviate the symptoms of depressive illness, but these management plans are unable to completely reverse the multifactorial pathology of depression, and the antidepressant medications may produce side effects and adverse drug reactions which may turn down the quality of life of patients. Research has shown that the gut microflora interacts with the brain through various mechanisms, and this leads to the recognition of the microbiome in managing mental health. By unveiling the complexities involved in this area can help to develop novel strategies to treat the depressed patients and to prevent the public from falling to depressive disorder.
Keywords: Gut microbiome, depression, neurotransmitters
Effect of Time and Haemolysis on Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) Measurement on Blood Samples
Authors: Eshag Tahia Jafar Abdo Alhakam , Merghani Maye M. , Babiker Nihad Elsadig 
Published: December 2021

Background: Coagulation, also known as blood clotting, is the process by which blood convert from a liquid to a gel, forming a blood clot. It referred to haemostasis, the stopping of blood loss from a damaged vessel, followed by repair.
Material and methods: This was cross sectional study conducted at the albawasla medical laboratory, Khartoum, Sudan during the period August to November, 2021 and to evaluate the effect of time and hemolysis on prothrombin time and activated partial thromboplastin time tests. 50 samples (case group) were collected from the patients attending police teaching hospital and requested to the PT and APTT test in addition to that,50 apparently healthy donors with no history of any coagulation problems or any chronic disease were selected as control group. Three ml of venous blood samples were collected in container with Tri Sodium Citrate anticoagulant. The coagulation tests (PT and APTT) were performed using semiautomatic device (coagulometer machine MI).
Results: The result of this study revealed that; when compared the measurement of PT and APTT immediately and after one hour there was insignificant differences (p. v.>0.05). also when compared the measurement of PT and APTT between hemolyzed and non-hemolyzed samples there was significant differences ( p. v.<0.05) in addition when compared case and control for the PT and APTT immediately, after one hour, hemolyzed and non-hemolyzed sample there was significant differences ( p. v.<0.05) except the APTT hemolyzed samples and insignificant differences with age and gender ( p. v.>0.05). For the correlation there was significant correlation in the case group for the PT and APTT immediately, after one hour, and hemolyzed samples.
Conclusion: In the cases group results showed insignificant differences in the results of PT and APTT between immediate sample and after 1 hour in and significant differences in the results of PT and APTT between hemolyzed and non-hemolyzed samples, also there was insignificant differences between age and gender, immediately, after one hr. and hemolyzed sample in PT and APTT.
Keywords: Homeostasis, hemolyzed sample, PT and APTT
The Application of Big Data in Modern National Economy and Politics
Authors: Tian Weili 
Published: December 2021

Big data is a new stage of informatization development. With the convergence and integration of information technology and human production and life, the rapid spread of the Internet, global data showing explosive growth and massive agglomeration, have had a significant impact on economic development, social governance, national management, and people’s lives.Countries around the world regard the promotion of economic digitization as an important driving force for innovation and development, and have made forward-looking layouts in cuttingedge technology research and development, data open sharing, privacy and security protection, and talent training.In-depth understanding of the current situation and trends of big data development, and its impact on economic and social development, analyze the achievements and existing problems of my country’s big data development, summarize and discuss the government’s response strategies, and promote the innovation of government management and social governance models, and realize government decision-making Identification, precise social governance, and efficient public services all have important meanings.
Investigasi Pengaruh Step Training pada Metode Single Shot Multibox Detector untuk Marker dalam Teknologi Augmented Reality
Authors: Sutama Vivian Alfionita , Wibowo Suryo Adhi , Rahmania Rissa 
Published: December 2021

Nowadays, Artificial Intelligence is one of the most developing technology, especially on Augmented Reality (AR). AR is a technology which connected between real world and virtual in a real time that allows user to interact directly and display it in 3D. AR technology has two methods, that are AR based on marker and AR based on markerless. However, AR based on marker need an object detection system which has high performance as an interaction tools between user and the device. Single shot multibox detector (SSD) is an object detection algorithm that has fast learning computation and good performance. This method is affected by some parameters like number of epoch, learning rate, batch size, step training, etc. However, to create a good system it took a long process such as taking dataset, labelling process, then training and testing models to gain the best performance. In this experiment, we analyze SSD method in AR technology using inception architecture as pre-trained Convolutional neural network (CNN), and then do transfer learning to minimize amount training time. The configuration that used is the number of step training. The result of this experiment gets the best accuracy in 70.17%. Then, the best performance is used as an object detection model for marker’s AR technology.Abstrak Saat ini, Artificial intelligence merupakan teknologi yang sedang berkembang pesat. Salah satunya adalah teknologi Augmented Reality (AR). AR adalah teknologi yang menggabungkan dunia nyata dengan virtual secara real-time dengan interaksi pengguna secara langsung dan menampilkannya dalam bentuk 3D. Teknologi AR ini memiliki dua metode yaitu dengan marker dan markerless. Dalam perkembangannya, AR berbasis marker membutuhkan sistem deteksi objek yang memiliki performa tinggi sebagai alat interaksi antara pengguna dengan perangkatnya. Single shot multibox detector (SSD) merupakan algoritma deteksi objek yang memiliki komputasi pembelajaran dan kinerja yang baik. Metode ini dipengaruhi oleh beberapa parameter seperti jumlah lapisan konvolusi, epoch, learning rate, jumlah batch, step training, dll. Namun, dalam mengimplementasikannya diperlukan proses yang cukup panjang seperti, pengambilan dataset, proses pelabelan, proses pelatihan menggunakan metode SSD, dan melakukan pengujian terhadap beberapa model untuk mencari perfomansi paling baik. Dalam percobaan ini, kami melakukan analisis terhadap metode SSD pada teknologi AR menggunakan arsitektur Inception sebagai pre-trained Convolutional neural network (CNN), kemudian dilakukan transfer learning untuk memperkecil jumlah kelas data pelatihan dan waktu pelatihan data. Konfigurasi yang digunakan berupa jumlah step pada pelatihan. Hasil dari penilitian ini menunjukan akurasi terbaik sebesar 70,17%. Kemudian, perfomansi terbaik digunakan sebagai model deteksi objek untuk marker pada teknologi AR.
Optimasi Keamanan Informasi Pendaftaran Event Menggunakan Teknologi Blockchain
Authors: Busthomi Iqbal , Riadi Imam , Umar Rusydi 
Published: December 2021

Abstract CV. Nyebar is an IT-based start-up that deals with event data management using a web-based application. The Event system provides account registration services as a Member and Organizer. Members of the Event System must first have an account and log-in to be able to register for the event. The process of registering events so far has not been properly secured. The event registration process will send registrant information, but the information sent has not been secured and validated first, so the Event System is still vulnerable to cyber-attacks including the registration data sniffing attack and Distributed Denial of Service (DDoS) attacks. DDoS attacks are carried out by sending messages and packet requests continuously to the business sector, hosting, social sites originating from bot at one time, resulting in overloaded network servers because of the resources (bandwidth, memory, and CPU usage) they have. the network server is used up. Blockchain which has three techniques/mechanisms including the use of hashes and proof-of-work mechanisms which can be an alternative security for event registration information because it can maintain information security, data consistency, and DDoS attacks.Keyword: Web Application, Distributed Denial of Service (DDoS), BlockchainAbstrak CV. Nyebar merupakan start-up berbasis IT yang bergelut dibidang pengelolaan data event menggunakan sebuah aplikasi berbasis web. Sistem Event menyediakan layanan pendaftaran akun sebagai Member dan Organizer. Member dari Sistem Event harus memiliki akun dan log-in terlebih dahulu untuk mendaftar sebuah event. Proses pendaftaran event sejauh ini belum diamankan dengan baik. Proses pendaftaran event akan mengirimkan informasi pendaftar, namun informasi yang dikirimkan belum diamanakan dan divalidasi terlebih dahulu, sehingga Sistem Event masih rentan akan serangan siber diantaranya adalah serangan sniffing data pendaftaran dan serangan Distributed Denial of Service (DDoS). Serangan DDoS dilakukan dengan mengirimkan pesan dan permintaan paket secara terus menerus kepada sektor bisnis, hosting, situs sosial yang berasal dari bot dalam satu waktu, sehingga mengakibatkan server jaringan menjadi overload karena sumber daya (bandwith, memory, dan CPU usage) yang dimiliki server jaringan habis terpakai. Blockchain yang memiliki dua teknik/mekanisme antara lain adalah penggunaan hash dan mekanisme proof-of-work, yang dapat menjadi alternatif pengamanan informasi pemdaftaran event karena dapat menjaga keamanan informasi, kekonsistenan data, dan serangan dari DDoS.Keyword: Aplikasi Web, Distributed Denial of Service (DDoS), Teknologi Blockchain
Klasifikasi Glaukoma Menggunakan Artificial Neural Network
Authors: Qhisthana Pratika Alva Rischa , Magdalena Rita , Nur Fuadah R Yunendah 
Published: December 2021

Abstract Glaucoma is an eye disease caused by increased eyeball pressure resulting in damage to the optic nerve and the second leading cause of blindness after cataracts. Nerve damage often occurs without symptoms so that an early examination can reduce the risk of glaucoma. Therefore, the authors designed a glaucoma detection system through eye fundal images that can facilitate the detection of glaucomaby extracting various features like Rim to Disc Ratio, Cup to Disc Ratio (CDR), Vertical Cup to Disc Ratio (VCDR), Horizontal Cup to Disc Ratio (HCDR), and Horizontal to Vertical CDR (H-V CDR) with Morphological Operations dan Thresholding for segmentation of Optic Disc (OD) and Optic Cup (OC). Artificial Neural Network (ANN) is used as a classifier of glaucoma. Through this method, the test data can be divided into two classifications namely normal eyes and glaucoma eyes. 62 pieces of data will be trained and 62 pieces of data will be tested. The results obtained aim to facilitate early detection of glaucoma eyes. Accuracy on training data reaches 100% and accuracy in this study is reached 93.5484%.Keyword: Glaucoma, Morphological Operation, Thresholding, Artificial Neural Network AbstrakGlaukoma adalah penyakit mata yang disebabkan oleh peningkatan tekanan bola mata sehingga terjadi kerusakan saraf optik dan dapat menyebabkan kebutaan nomor dua setelah katarak. Kerusakan saraf sering terjadi tanpa gejala sehingga pemeriksaan dini dapat mengurangi resiko dari glaukoma. Oleh karena itu, penulis merancang suatu sistem untuk mendeteksi glaukoma melalui citra fundus mata dengan mengekstraksi beberapa fitur yaitu Rim to Disc Ratio, Cup to Disc Ratio (CDR), Vertical Cup to Disc Ratio (VCDR), Horizontal Cup to Disc Ratio (HCDR), dan Horizontal to Vertical CDR (H-V CDR) dengan mengsegmentasi Optic Disc (OD) dan Optic Cup (OC) dengan menggunakan metode Morphological Operations dan Thresholding. Artificial Neural Network (ANN) digunakan sebagai metode klasifikasi glaukoma. Melalui metode tersebut, data uji dapat dibagi dalam dua klasifikasi yaitu mata normal dan mata glaukoma. Data latih yang akan diambil sebanyak 62 buah dan data uji yang akan diambil sebanyak 62 buah. Hasil yang diperoleh bertujuan untuk memudahkan mendeteksi secara dini mata glaukoma. Akurasi pada data latih mencapai 100% dan akurasi pada data uji mencapai 93,5484%.Kata kunci: Glaukoma, Morphological Operation, Thresholding, Artificial Neural Network
Effects of Class II elastics during growth on the functional occlusal plane according to skeletal pattern and extraction vs nonextraction
Authors: Davidovitch Moshe , Konstantarakis Evangelos , Athanasios Vottas , Sella-Tunis Tatiana 
Published: December 2021

ABSTRACT

Objectives
To investigate the effect of Class II intermaxillary elastics on the functional occlusal plane (FOP) of growing patients.

Materials and Methods
A total of 50 participants aged 11 to 16 years were selected from a university clinic archive &gt;1-year after treatment and after undergoing 6 months of Class II elastic wear, taking pretreatment (T0) and posttreatment (T1) lateral cephalometric radiographs, and consenting to participate at recall (T2). Participants were divided into 3 groups according to skeletal pattern or into 2 groups according to treatment with extraction (E) or nonextraction (NE). Angular changes of FOP relative to the Sella-Nasion (SN), mandibular plane (MP), and Frankfort horizontal (FH) were compared within and between groups.

Results
A statistically significant reduction of FOP-SN/FH, but not of FOP-MP, was found from T0–T1–T2 when all patients were grouped together. FOP-SN/MP/FH was significantly the largest in the patients with a hyperdivergent skeletal pattern, but lowest in the patients with a hypodivergent skeletal pattern at T0, T1, and T2 (P &lt; .032). FOP-MP at T0–T2 was statistically larger in group E than in group NE (P &lt; .02). No differences were found for FOP changes (change before treatment minus after treatment and change after treatment minus 1 year after treatment) between different skeletal patterns (P &gt; .433) and treatment groups (P &gt; .193).

Conclusions
Use of Class II elastics during the growth period was not found to show adverse effects on FOP rotation. Neither skeletal pattern nor treatment modality differed in the response to Class II elastics with regard to FOP changes. Individual patient growth pattern must be taken into consideration when treatment planning the use of Class II elastics. Orthodontists should take into account individual skeletal and growth patterns while using Class II elastics.
Remote results of generalized periodontitis treatment in patients with osteoarthrіtis
Authors: M. S. Zaliznyak  
Published: December 2021

The article presents long-term results of treatment of generalized periodontitis in patients with osteoarthritis using chloride-calcium-sodium mineral water of Novozbruchansk deposit with high salinity and of system administration of osteotropic drugs "Сalcemin" and "Aquadetrim".
State of the blood lipid profile in acute period of recurrent ischemic stroke
Authors: A. V. Kulmatytskyi  
Published: December 2021

In patients with both primary and recurrent ischemic stroke in its acute period the combined dyslipidemia with no probable differences was found which declared itself in an increase of general cholesterol, cholesterol of low den sity lipoproteins, cholesterol of extra low density lipoproteins, triglycerides and atherogenic factor at low concentrations of cholesterol of high density lipoproteins. There were no significant differences found between the indexes of lipidogram of different levels of severity in the primary ischemic stroke group as well as in the group of recurrent ischemic stroke, and no significant differences betweentheir same name levels of severity were found either.
Effect of methanol on the ultrastructure of chorioretinal complex of rats’ eyes in the early stages of the experiment
Authors: N. І. Molchanyuk  
Published: December 2021

Electron-microscopic structure of the chorioretinal complex were investigated (СRC), [choriocapillaries (HC) – retinal pigment epithelium (RPE) – photoreceptor cells (FC)], of white rats in a period of 40 min. to 3 days after a single intraperitoneal dose of methanol 0.75 g/kg body weight. It has been established that RPE cells are the most responsiveto the dose of the methanol used. In the dynamics (from 40 min. up to 3 days), they grew destructive changes of mitochondria and elements of smooth endoplasmic reticulum, the smoothness of the basal folds and patchy destruction of the apical microvilli. The changes in CC and FC were similar. By the end of the observation period, these phenomena in the CRC structure spread to a larger number of cells. At the same time, during the whole period of the study, and, in particular, after a day, some signs of recovery of compensatory nature were obvious. Attention is drawn to pronounced reaction of mitochondria, which are energy forming structures of a cell.
Using cell indirect revascularization for chronic limb ishemia
Authors: R. V. Saliutin  
Published: December 2021

The problem of treating patients with no reconstruction of peripheral arterial bed is relevant and it still remans open. The results of the pilot study with a simulated limb ischemia, demonstrated the feasibility and efficacy of fetal liver progenitor cells in activating regenerative and recovery processes as well as angiogenesis.The aim of the research was to investigate the clinical efficacy of cell "indirect" revascularization method in the complrehensive treatment of patients with chronic limb ischemia.The developed method of fetal human liver progenitor cells application in treatment of lower limb ischemia is an effective and affordable method of indirect revascularization. This method is indicated for use in patients whose vascular bed can not be reconstructed, and in elderly patients with severe concomitant pathologies.
Electroneuromyographical and immunological paralells in patients with diabetes mellitus type 2 complicated with polyneuropathy
Authors: L. A. Skrypko  
Published: December 2021

This article presents and analyzes the data from a study of the immune status and the role of immune factors in the progression of polyneuropathy in patients with type 2 diabetes mellitus. The relationship between markers of the functional state of myelin and some parameters of the immune system are ascertained. The most sensitive are tibial nerve characteristics and in most cases – the residual latency period, that is the functional state index of myelin of the most dystal nerves’ segments. It was found that the progression of the polyneuropathy severity is accompanied by the secondary demyelination as a result both of the deepening axonopathy process and some immune disorders.
Hypoglycemic syndrome (literature review)
Authors: P. M. Liashuk  , I. V. Skhodnytskyi  , R. P. Liashuk  , N. I. Stankova  
Published: December 2021

The article presents the literature data about the basic mechanisms regulating blood glucose in normal and pathological conditions, etiology and pathogenesis of hypoglycemia by endocrine and non-endocrine diseases, and also features clinical displays of hypoglycemic syndrome.
Molecular-genetic mechanisms of phisiologic functions time distribution in mammals (bibliographical review and author's own data)
Authors: V. P. Pishak  , R. Y. Bulyk  , K. V. Vlasova  
Published: December 2021

The review presents current data about the course of physiologic processes, controlled by circadian clock system. Deregulation of these mechanisms can cause disorders in cellular signal cascades and lead to pathological processes.
Investment of members of dermatovenereology department of Bukovinian State Medical University in the development of dermatovenereological service in Chernivtsi region
Authors: O. I. Denysenko  , T. P. Vysochanska  , M. P. Perepichka  , M. Y. Haevska  , L. O. Hulei  , Y. P. Karvatska  
Published: December 2021

In the article are presented the historical and modern data on the participation of members of dermatovenereology department of Bukovinian State Medical University in the formation and development of dermatovenereological service on the territory of Chernivtsi region (Northern Bukovyna).
Diagnosis of Genital Tract Infections in Pregnant Women With Pulmonary Tuberculosis
Authors: V. V. Harbuziuk  , S. P. Poliova  
Published: December 2021

The article presents data on the diagnosis of genital tract infections in patients with pulmonary tuberculosis, whose pregnancy ended in premature delivery. It is shown that in this contingent of pregnant women, vaginal microflora undergoes qualitative and quantitative changes, early detection of which contributes to the effective prevention of a preterm birth.
The sex related effects of intermittent hypobaric hypoxia on the oxidized modification of proteins in the gingival tissues in immature rats under conditions of changed photoperiod
Authors: R. R. Dmytrenko  , H. I. Khodorovskyi  , V. A. Honcharenko  
Published: December 2021

It is shown in experiments that intermittent hypoxia (equivalent to the altitude 4000 meters, 2 hours per day for 14 days) changes the capacity of the oxidized modification of proteins (OMP) in the gingival tissues of immature albino rats. The result of hypoxic effects depends on the sex of animals: in males it causes a decrease of proteins peroxidation intensity both of basic and neutral nature; in females – only a tendency to decrease of the basic OMP.Functional state of the pineal gland changed by experimental conditions (14 days of illumination – “physiological pinealectomy”, or 14 days of darkness – stimulation of the pineal gland) influenced the effects of hypoxia on the OMP in the gingival tissues. The darkness heightens the decreasing effects of hypoxia on the capacity of OMP in the gingival, which is more pronounced in male rats.Our results suggest that by an application of combination of intermittent hypobaric hypoxia and the darkness it is possibleto prevent the process of accumulation of OMP in the gingival tissues.