bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFECTO DE UN PROGRAMA DE ACONDICIONAMIENTO FÍSICO EN LA AUTONOMÍA FUNCIONAL DEL ADULTO MAYOR DEL MUNICIPIO DE MIRAFLORES.
Authors: Holguín Ruíz Fredy Alexander , Caro Cely William Fernando , Chaparro Díaz Yineth Amparo 
Published: November 2021

Introducción: El ciclo vital de los seres humano se encuentra conformado por cuatro periodos o etapas elementales: 1.- la infancia, 2.- la adolescencia, 3.- la adultez y 4.- la vejez. Se puede evidenciar que en la infancia el hombre es considerado como un ser dependiente a sus cuidadores, pero, a medida que pasa el tiempo se va convirtiendo en un ser con independencia en diferentes aspectos de la vida, que son producto del crecimiento y el desarrollo en diferentes ámbitos de la vida hasta llegar al periodo de la vejez, donde la independencia funcional que la persona ha obtenido, se ve afectada considerablemente, producto de un proceso natural de detrimento de las funciones del ser humano. En este sentido, se hace necesario llevar a cabo diversas actividades que disminuyan el efecto de la edad y retrasen el proceso de envejecimiento del cuerpo. Objetivo General: Determinar el efecto de un Programa de acondicionamiento Físico en la autonomía funcional en el Adulto Mayor del Hogar San José del municipio de Miraflores, Boyacá. Metodología: Para ello, se desarrolló un programa de acondicionamiento Físico durante 12 semanas, con una frecuencia de 3 veces por semana. Con una muestra de 15 adultos mayores, que cumplieron con los criterios de inclusión, con una edad promedio de 65,64 ± 75,58; y a los que se les aplicó como medida de evaluación en un antes y un después del programa, el test de la prueba de la caminata de los 6 minutos. Resultados: El análisis de los resultados revela que entre el pre-test y el pos-test se obtuvo una significancia bilateral de p=0,99 (para todos p≤0,05). Conclusiones: Lo anterior, permite determinar que el programa de 12 semanas de acondicionamiento físico no tiene efecto sobre la autonomía funcional del adulto mayor.
Postgraduate Students’ Individual Educational Paths: Design Principles and Implementation Conditions (on the Example of a Technical University)
Authors: Klimova A. S. , Krasinskaya L. F. 
Published: November 2021

The article addresses the importance of introducing individual educational paths (IEP) in training research and pedagogical personnel in postgraduate studies. The idea of an individual approach of learning is enshrined in a number of documents including the Federal Law “On Education in the Russian Federation”. However, in practice, there are obstacles to the implementation of IEP: the presence of regulatory documents governing the organization of the educational process in higher education, the predominance of the group form of organizing classes, the unpreparedness of teachers for the implementation of the personalized learning model. We find it reasonable to start the implementation of IEP at the level of postgraduate training, given the relative small number of students, as well as their cognitive independence and well-developed educational skills. The design of the IEP will make it possible to better take into account the initial competencies of postgraduate students, their cognitive needs and goals in further career advancement (orientation towards teaching, research, production activities), which are largely determined by the nature and level of professional education.The article reveals the specifics of the training of research and pedagogical personnel in the postgraduate study of a technical university, identifies the factors that have an impact on the way postgraduate students build their learning trajectories, substantiates the principles of IEP design, and describes the stages of personalized learning technology. The research data on the readiness of postgraduate students to design IEP on their own are presented. The results of the survey of post graduate students and their supervisors indicate that there are sufficient grounds for the successful implementation of a personalized learning model using IEP. Postgraduate students of a technical university are well versed in information resources, actively use University’s services of the electronic educational environment. They are able to determine the goals of educational and scientific activities, assess their competencies, and analyze achievements and failures. Most of scientific advisors are ready to assist postgraduate students in IEP designing. The article analyzes the difficulties that universities may encounter when introducing a new teaching model, and substantiates the conditions for the successful implementation of IEP in postgraduate studies.
Postgraduate Professional Education in China: The State and Development Trends
Authors: Donetskaya S. S. , Wang Bing 
Published: November 2021

Modern China is one of the fastest growing economies in the world. This success has been achieved thanks to the creation of technological enterprises and the widespread introduction of innovations aimed at increasing labor productivity and making efficient use of other factors of production. China is undergoing a transformation in its economic growth environment. As an important force of technological progress, which is the key to transforming a country’s economy, it is human capital, and its foundation is high-quality education. Moreover, one of the main priorities of the Chinese Government is to build the “national scientific force” in the hope that China will make breakthroughs in advanced economic fields. Therefore, the development of the system of postgraduate professional education, including the training of undergraduates and doctoral students, is a top priority.This article gives a brief introduction to the history of the development of postgraduate professional education in China, shows the features of its formation, significant events and achievements obtained at each stage of the scientific training system formation. There is a detailed analysis of the processes taking place at the present stage, which began in 2010. The Chinese Government plays a primary role in establishing a competitive national system of postgraduate education.Based on data from the Ministry of Education of China, official statistics, publications that are publicly available on the Chinese Internet, and scientific articles published in leading world publications, the article shows how the number of universities training undergraduates and doctoral students, the number and structure of students in various specialties have changed over the past decade. The article presents the modern project of national scientific training system reform.
Принцип юридичної визначеності (legal certainty) у рішеннях Конституційного Суду України
Authors: Onyshchuk  I. I 
Published: November 2021

Метою статті є аналіз практики застосування принципу юридичної визначеності та з’ясування його співвідношення з верховенством права.
Новизна статті полягає в характеристиці юридичної визначеності як однієї з найважливіших, очевидно недостатньо досліджених і дискусійних правових категорій з точки зору загальнонаукових, філософських, теоретико-правових і практичних позицій.
З’ясовано, що юридична визначеність (legal certainty) – одна зі складових широко визнаного та закладеного в основу практики Європейського суду з прав людини принципу верховенства права (the rule of law), яка є базовою у розумінні верховенства права. Аргументовано, що юридична визначеність є ключовою у створенні правових методів, за допомогою яких приймається, тлумачиться та застосовується законодавчий акт.
Висновки. З метою подолання недоліків правового регулювання, Конституційний Суд України, викладаючи юридичні позиції, в своїх рішеннях звертається до суб’єктів законотворчої і правозастосовної діяльності для забезпечення однозначного розуміння і тлумачення норм права, однакового їх практичного застосування. Зміст поняття юридичної визначеності з позиції Конституційного Суду України розкривається через такі техніко-юридичні показники якості нормативно-правових актів, як чіткість, зрозумілість, однозначність норм права; право особи у своїх діях розраховувати на розумну стабільність чинного законодавства та можливість передбачати наслідки застосування норм права (легітимні очікування). Поняття «юридична визначеність» співвідноситься з поняттям «верховенство права» як частина його обсягу, однак не вичерпує його.
Substitution Buccal Mucosal Graft Urethroplasty for Long Segment Anterior Urethral Stricture : Our Experience in Dorsolateral Onlay Approach
Authors: Nandy Shiba Prasad , Md Asaduzzaman - , Mazumder Kamal Uddin , Khan Sakhawat Mahamud , Ul Hoque Md Monowar 
Published: November 2021

Background: Currently the most favorable single stage procedure for management of long segment anterior urethral stricture is dorsal onlay technique of urethroplasty. This required circumferential extensive mobilization of the urethra, which might cause ischemia of urethra in addition to chordee. To evaluate the short term outcome of dorsolateral onlay BMG (Buccal Mucosal Graft) urethroplasty by unilateral urethral mobilization for treatment of long segment anterior urethral stricture
Materials and methods: A prospective experimental study from January 2016 to December 2018 is carried out in Department of Urology, Chittagong Medical College Hospital (CMCH) Chattogram, Bangladesh. Total 32 patients of long segment anterior urethral stricture were treated by dorsolateral onlay BMG urethroplasty by unilateral urethral mobilization. Stricture >2cm were included; RGU, MCU and Uroflowmetry were the mainstay of assessment. Success was defined as maximum flow rate >15 ml/s, normal RGU and/ urethroscopy. Failure considered as presence of obstructive symptoms, Qmax < 15 ml/s, stricture on RGU and any post-operative urethral intervention.
Results: Mean stricture length was 48.72mm (Range: 30-77mm) and mean follow up time was 22.4months (Range: 12-40 months). Three patients were found to develop stricture at proximal anastomotic site during follow up and required optical internal urethrotomy and considered as failure. 01 patients developed Surgical Site Infection (SSI) which resolved after regular dressing. Success rate was 90.7%
Conclusion: Dorsolateral onlay BMG urethroplasty by unilateral mobilization is feasible, safe and easily adoptable for long segment anterior urethral stricture with good short term outcome.
Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 14-17
Prevalence and Maternal Effects of Hypothyroidism in Pregnancy
Authors: Ferdousi Mahmuda Ashrafi , Baki Abdullah Al 
Published: November 2021

Background: Thyroid disorders are among the common endocrine problems in pregnant women. It is now well established that not only overt but subclinical thyroid dysfunction also has adverse effects on maternal and fetal outcome. There are few data from Bangladesh about the prevalence of thyroid dysfunction in pregnancy. With this background, this study aims to find prevalence of thyroid dysfunction in pregnancy and its impact on obstetrical outcome.
Materials and methods: It is an observational study done in a Combined Military Hospital (CMH) Chattogram during the period from February to December 2020 on 130 hypothyroid mothers to observe maternal effects of hypothyroidism. Patients were collected as per inclusion and exclusion criteria after informed written consent. Data was compiled and analyzed and presented.
Results: Among 1148 total patients,1018(89%) were normal and 130(11%) were diagnosed as hypothyroid.Among all the patients, 35% patientsare from inside the Chattogram and 65% are from outside. Among 130 hypothyroid cases age range revealed 20-45 years and 20 -30 years age group were 82(63.07%), 30-40 years age group was 40(30.76%) and >40 years age group were 8(6.15%). Primigravida was 48(36.92%) cases and multigravida was 82(63.08%) cases, anemia was present in 40(30.76%) cases, 10(7.69%) patients had hypertension, GDM and DM was found in 20(15.38%)and 3(2.30%) cases respectively, preconception hypothyroidism was found in 10(7.69%) and on Levothyroxine during ANC was 120(92.30%).Among all, 63(48.46%) cases were underwent vaginal delivery and 67(51.53%) cases underwent cesarean section. Untreated and irregular treatment in hypothyroidism are associated with pregnancy complications like spontaneous miscarriage 40(30.76%), maternal anaemia 55(42.30%), pre-eclampsia 4(3.07%), pre term birth 16(12.30%), postpartum haemorrhage 3(2.30%).
Conclusion: Hypothyroidism is a common clinical condition during pregnancy and it causes variable pregnancy outcome
Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 18-21
Post Operative Pain Management and Patient Satisfection : Experience at a Tertiary Care Hospital
Authors: Ferdoush Jannatul , Chowdhury Rajib Pal , Johora Fatema , Arifina Rafzana , Jeenia Fatiha Tasmin , Ata Maliha , Parveen Kohinoor , Hossain Sharif Mohammad Towfiq , Sharmeen Shagorika , Rahman MD Sayedur 
Published: November 2021

Background: Pain is an inevitable part of the postoperative experience. Current study was designed to assess the pattern of analgesic use, the adequacy of post operative pain control by documenting pain scores and patient satisfaction by documenting the pain perception score of the postoperative patients 48 hours after surgery.
Materials and methods: This was a formative research and includes a mix of descriptive cross-sectional study carried out in the Department of Gynecology and Obstetrics, General Surgery and Orthopedics Surgery of Chattagram Maa-O-Shishu Hospital Medical College (CMOSHMC) during the month of January, 2018 to July, 2019.
Results: A total of 180 patients underwent surgery were included in this study. Baseline data were collected both retrospectively and prospectively. Only analgesic used immediately after operation in three departments were Pethidine (100%). Diclofenac sodium suppository were used in appendectomy and cesarean section (50/60, 83%) and (26/60, 43%) respectively. Mostly, Diclofenac Sodium IV (55/60, 91%) was used in lower limb surgery. The maximum pain score were 5.3 (SD=2.3), 5.6 (SD =1.9), and 6.1 (SD =1.3) during coughing in the first 8 hour and minimum pain score 2.4 (SD =1.0), 2.2 (SD = 0.8) and 1.7 (SD=1.3) at rest 48 hours after cesarean section, appendectomy and lower limb surgery respectively. But pain score eventually increased during coughing 48 hours after surgery. After 48 hours of surgery maximum pain perception score 3.9 (SD = 0.9) in lower limb surgery and minimum perception score were 3.5 (SD =1.8) in cesarean section. Majority of the appendectomy patient (76%) satisfied with pain management where as only 43% satisfied in case of cesarean section.
Conclusion: This study enabled the researchers to get a precise picture of the current state of POPM in different hospitals, as well as identify particular needs for improving such practices in health care facilities and implementing an educational intervention in order to improve the post operative pain management.
Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 69-73
Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss
Authors: Du Jingke , He Zihao , Cui Junqi , Li Hanjun , Xu Mingming , Zhang Shuhong , Zhang Shuangyan , Yan Mengning , Qu Xinhua , Yu Zhifeng 
Published: November 2021

Emerging evidence indicates that bone mass is regulated by systemic energy balance. Temperature variations have profound effects on energy metabolism in animals, which will affect bone remodeling. But the mechanism remains unclear. 2-month-old C57BL/6J male mice were exposed to cold (4°C) and normal (23°C) temperatures for 28 days and the effects of cold exposure on bone mass was investigated. Micro-computed tomography results showed that bone volume fraction was significantly reduced after 14 days of exposure to cold temperature, and it was recovered after 28 days. Ploton silver staining and immunohistochemical results further revealed that exposure to cold decreased canalicular length, number of E11-and MMP13-positive osteocytes after 14 days, but they returned to the baseline levels after 28 days, different from the normal temperature control group. In addition, change of Caspase-3 indicated that exposure to cold temperature augmented apoptosis of osteocytes. In vitro results confirmed the positive effect of brown adipocytes on osteocyte‘s dendrites and E11 expression. In conclusion, our findings indicate that cold exposure can influence bone mass in a time-dependent manner, with bone mass decreasing and recovering at 2 and 4 weeks respectively. The change of bone mass may be caused by the apoptosis osteocytes. Brown adipocyte tissue could influence bone remodeling through affecting osteocyte.
Improving the Stability of Protein–Protein Interaction Assay FlimPIA Using a Thermostabilized Firefly Luciferase
Authors: Ohmuro-Matsuyama Yuki , Gomi Keiko , Shimoda Takuya , Yamaji Hideki , Ueda Hiroshi 
Published: November 2021

The protein–protein interaction assay is a key technology in various fields, being applicable in drug screening as well as in diagnosis and inspection, wherein the stability of assays is important. In a previous study, we developed a unique protein–protein interaction assay “FlimPIA” based on the functional complementation of mutant firefly luciferases (Fluc). The catalytic step of Fluc was divided into two half steps: D-luciferin was adenylated in the first step, while adenylated luciferin was oxidized in the second step. We constructed two mutants of Fluc from Photinus pyralis (Ppy); one mutant named Donor is defective in the second half reaction, while the other mutant named Acceptor exhibited low activity in the first half reaction. To date, Ppy has been used in the system; however, its thermostability is low. In this study, to improve the stability of the system, we applied Fluc from thermostabilized Luciola lateralis to FlimPIA. We screened suitable mutants as probes for FlimPIA and obtained Acceptor and Donor candidates. We detected the interaction of FKBP12-FRB with FlimPIA using these candidates. Furthermore, after the incubation of the probes at 37°C for 1 h, the luminescence signal of the new system was 2.4-fold higher than that of the previous system, showing significant improvement in the stability of the assay.
M6A-Mediated Upregulation of LINC00106 Promotes Stemness and Metastasis Properties of Hepatocellular Carcinoma via Sponging Let7f
Authors: Liang Wenjin , Wang Yan , Zhang Qinyu , Gao Min , Zhou Haizhou , Wang Zhenran 
Published: November 2021

Background: Hepatocellular carcinoma (HCC) cells exhibit the stemness property, which makes the patient with HCC prone to tumor recurrence and metastasis. Despite the prominent regulatory role of long non-coding RNAs (lncRNAs) in tumor stemness, the roles and molecular mechanisms of LINC00106 in HCC are poorly understood.Methods: LINC00106, let7f and periostin expression levels in tissue specimens and cell lines were assessed through qRT-PCR and immunohistochemistry (IHC). Various in vivo and in vitro assays, namely sphere/colony formation, proportion of side population cells (SP%), invasion, migration, western blot, and murine xenograft model were employed for assessing the stemness and metastatic properties of HCC cells. Luciferase reporter assays, RNA-seq, RNA pull-down, RNA immunoprecipitation (RIP) were conducted to clarificate the target gene and analyze the underlying mechanisms.Results: LINC00106 was prominently upregulated in tissues and cell lines of HCC. Patients having a high LINC00106 level exhibited a poor outcome. Under in vivo and in vitro conditions, the stemness and metastatic properties of HCC cells were augmented by LINC00106. Additionally, LINC00106 was found to sponge let7f to upregulate periostin, which lead to the activation of periostin-associated PI3K-AKT signaling pathway. Moreover, m6A methylation was found to cause LINC00106 upregulation while maintaining LINC00106 RNA transcript stability.Conclusion: m6A methylation triggers the upregulation of LINC00106, which promotes the stemness and metastasis properties in HCC cells by sponging let7f, thereby resulting in periostin activation. The findings indicate the potential of LINC00106 as a diagnostic marker and therapeutic target for HCC.
Potential Mechanism of Dingji Fumai Decoction Against Atrial Fibrillation Based on Network Pharmacology, Molecular Docking, and Experimental Verification Integration Strategy
Authors: Liang Yi , Liang Bo , Chen Wen , Wu Xin-Rui , Liu-Huo Wu-Sha , Zhao Li-Zhi 
Published: November 2021

Background: Dingji Fumai Decoction (DFD), a traditional herbal mixture, has been widely used to treat arrhythmia in clinical practice in China. However, the exploration of the active components and underlying mechanism of DFD in treating atrial fibrillation (AF) is still scarce.Methods: Compounds of DFD were collected from TCMSP, ETCM, and literature. The targets of active compounds were explored using SwissTargetPrediction. Meanwhile, targets of AF were collected from DrugBank, TTD, MalaCards, TCMSP, DisGeNET, and OMIM. Then, the H-C-T-D and PPI networks were constructed using STRING and analyzed using CytoNCA. Meanwhile, VarElect was utilized to detect the correlation between targets and diseases. Next, Metascape was employed for systematic analysis of the mechanism of potential targets and protein complexes in treating AF. AutoDock Vina, Pymol, and Discovery Studio were applied for molecular docking. Finally, the main findings were validated through molecular biology experiments.Results: A total of 168 active compounds and 1,093 targets of DFD were collected, and there were 89 shared targets between DFD and AF. H-C-T-D network showed the relationships among DFD, active compounds, targets, and AF. Three functional protein complexes of DFD were extracted from the PPI network. Further systematic analysis revealed that the regulation of cardiac oxidative stress, cardiac inflammation, and cardiac ion channels were the potential mechanism of DFD in treating AF. Addtionally, molecular docking verified the interactions between active compounds and targets. Finally, we found that DFD significantly increased the level of SIRT1 and reduced the levels of ACE, VCAM-1, and IL-6.Conclusions: DFD could be utilized in treating AF through a complicated mechanism, including interactions between related active compounds and targets, promoting the explanation and understanding of the molecular biological mechanism of DFD in the treatment of AF.