bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized four new sums of graphs and their Zagreb indices
Authors: Patil Shreekant , Basavanagoud Bommanahal 
Published: January 2021

The first Zagreb index of a graph [Formula: see text] is the sum of squares of the degrees of the vertices of [Formula: see text]. In this paper, we introduce generalized four new sums of graphs and study the first Zagreb index and coindex of the resulting graphs. In addition, we give the short proof for the earlier results of Deng, Sarala, Ayyaswamy and Balachandran [Appl. Math. Comput. 275 (2016) 422–431] on the first Zagreb index of four operations on graphs by different approach.
Developing a Conceptual Model for Process Capability in the Brazilian Data Protection Regulation Context
Authors: Muncinelli Gianfranco , de Lima Edson Pinheiro , Cestari José Marcello A. P. , Deschamps Fernando , da Costa Sergio E. Gouvea 
Published: January 2021

A capability model describes the complete set of features that an organization requires to execute its business model or fulfill its mission; the user’s environment must be increasingly included in the design and development of necessary and desired solutions. For this, the development of the model and its application are central issues. An account should be taken of legislation involving the protection of individuals’ data in any relationship involving the processing of information classified as personal data; as well as its impact on public and private companies across the country, considering any size and market segment, and taking into account the need to comply with legal requirements efficiently and sustainably, mitigating risk factors. Transdisciplinarity characterizes this research, as the digital transformation process integrates legal, technological aspects, risks, business analysis, good practices and standards of information technology management and digital compliance. This paper addresses this problem by analyzing the main areas of contribution to the assessment of process capability for digital transformation concerning cybersecurity in the context of personal data protection legislation. Finally, the main components of the future capability model are presented. The paper presents the components of the MCP-LGPD capability model (process capability model — general data protection law) to understand the functionality and underlying flows in the context of Lei Geral de Proteção de Dados (LGPD). The MCP-LGPD comprises of four levels of capacity that indicates the degrees of evolution and implementation of certain guidelines related to attributes. All the model attributes are presented before the interviews with the specialists, who will validate these attributes.
Porphyry Cu–Au ± Mo mineralization hosted by potassic igneous rocks: implications from the giant Peschanka porphyry deposit, Baimka Trend (North East Siberia, Russia)
Authors: Chitalin Andrey F. , Baksheev Ivan A. , Nikolaev Yurii N. , Djedjeya Georgy T. , Khabibullina Yuliya N. , Müller Daniel 
Published: January 2021

Abstract

Porphyry Cu–Au ± Mo mineralization at Peschanka is hosted by monzodiorite and monzonite intrusions with high-K calc-alkaline to shoshonitic compositions and dated at about 144.1 ± 1.5 Ma, using U/Pb zircon ages. The Cretaceous intrusions are emplaced in a melange of Cretaceous island arcs, a tectonic setting comparable with other world-class porphyry Cu–Au deposits, such as Oyu Tolgoi, Mongolia and Pebble, Alaska. Abundant primary magnetite contents of the Peschanka intrusions, as well as numerous gypsum and anhydrite veins, reflect the high oxidation states of their parental magmas. This mineralogical interpretation is confirmed by high whole-rock Fe
2
O
3
/FeO ratios and high V/Sc ratios of the rocks of up to 1.27 and up to 21.9, respectively. The whole-rock Eu/Eu* ratios of the Peschanka intrusions are ≥1 which is also typical for potassic igneous rocks with high oxidation states. Abundant amphibole and biotite phenocrysts of the intrusions as well as their high whole-rock Sr/Y ratios of up to 225 document significantly high H
2
O contents of the high-K magmas. Peschanka contains a resource of >9.5 Mt of copper at an average grade of 0.43 wt% and 16.5 Moz of gold at a high average grade of 0.23 g/t and thus represents one of the largest undeveloped greenfield copper projects worldwide. The vicinity of Peschanka still offers significant brownfield exploration potential. The hypogene vein-related and disseminated Cu–Au ± Mo sulfide mineralization at Peschanka is structurally controlled by significant NE-trending strike-slips that acted as the conduits for the hydrothermal fluids. The central part of the orebody consists of high-grade north–south-trending sheeted quartz–bornite veining with unusually high vein densities. The highest Cu and Au grades are directly correlated with high vein densities. Peschanka is defined by distinct hydrothermal alteration zones including potassic, phyllic, propylitic and argillic assemblages, but a distinct lack of advanced argillic alteration. The mineralization itself is also zoned ranging from a central Mo–Cpy–Bn sulfide assemblage to a peripheral Py–Mt-dominated zone (‘pyrite-shell’). Late-stage polymetallic assemblages overprint and surround the main stockwork zone.
Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment
Authors: Wang Hui Qin , Mulford Iain J. , Sharp Fiona , Liang Jinsheng , Kurtulus Sema , Trabucco Gina , Quinn David S. , Longmire Tyler A. , Patel Nidhi , Patil Roshani , Shirley Matthew D. , Chen Yan , Wang Hao , Ruddy David A. , Fabre Claire , Williams Juliet A. , Hammerman Peter S. , Mataraza Jennifer , Platzer Barbara , Halilovic Ensar 
Published: January 2021

Abstract

p53 is a transcription factor that plays a central role in guarding the genomic stability of cells through cell-cycle arrest or induction of apoptosis. However, the effects of p53 in antitumor immunity are poorly understood. To investigate the role of p53 in controlling tumor-immune cell cross-talk, we studied murine syngeneic models treated with HDM201, a potent and selective second-generation MDM2 inhibitor. In response to HDM201 treatment, the percentage of dendritic cells increased, including the CD103+ antigen cross-presenting subset. Furthermore, HDM201 increased the percentage of Tbet+Eomes+ CD8+ T cells and the CD8+/Treg ratio within the tumor. These immunophenotypic changes were eliminated with the knockout of p53 in tumor cells. Enhanced expression of CD80 on tumor cells was observed in vitro and in vivo, which coincided with T-cell–mediated tumor cell killing. Combining HDM201 with PD-1 or PD-L1 blockade increased the number of complete tumor regressions. Responding mice developed durable, antigen-specific memory T cells and rejected subsequent tumor implantation. Importantly, antitumor activity of HDM201 in combination with PD-1/PD-L1 blockade was abrogated in p53-mutated and knockout syngeneic tumor models, indicating the effect of HDM201 on the tumor is required for triggering antitumor immunity. Taken together, these results demonstrate that MDM2 inhibition triggers adaptive immunity, which is further enhanced by blockade of PD-1/PD-L1 pathway, thereby providing a rationale for combining MDM2 inhibitors and checkpoint blocking antibodies in patients with wild-type p53 tumors.

Significance:
This study provides a mechanistic rationale for combining checkpoint blockade immunotherapy with MDM2 inhibitors in patients with wild-type p53 tumors.
Um olhar crítico à descentralização de serviços públicos de saúde em atenção hospitalar
Authors: Pereira Fabrícia Helena Linhares Coelho da Silva 
Published: January 2021

Este trabalho objetiva identificar o panorama de contratação do setor privado sem fins lucrativos pelo Sistema Único de Saúde para realização de serviços de saúde de média e alta complexidade em atenção hospitalar, e a relação desse panorama com a diretriz de descentralização do sistema, que deve garantir atendimentos dos grandes centros urbanos às zonas onde os serviços públicos são mais escassos. Questiona-se se a contratação expandida de serviços hospitalares privados representa um afastamento das direções nacional e estadual da execução dos serviços de saúde a partir da municipalização generalizada. A metodologia de pesquisa é exploratória e descritiva, com base bibliográfica na literatura dos direitos Sanitário e Administrativo. A partir da análise dos gastos públicos com serviços hospitalares,nos últimos cinco anos, identifica-se que as entidades sem fins lucrativos tiveram mais investimento em produção hospitalar do que as esferas da administração pública direta e indireta de todos os entes. A título de contribuição para a busca de soluções para o problema, conclui-se que a menor participação da gestão nacional do SUS na prestação de serviços de saúde acarreta maior compra de serviços da iniciativa privada pelos entes, descumprindo a determinação constitucional de complementariedade da participação do setor privado no SUS. Ademais, a prestação de serviços hospitalares nesses moldes promove a falta de equilíbrio na alocação de leitos hospitalares, comprometendo a igualdade de condições no acesso às ações e aos serviços de saúde, objetivo da descentralização, e o adequado funcionamento do sistema.
Star Grass Lily Iphigenia stellata Blatter (Colchicaceae) – a new addition to the flora of Gujarat, India
Authors: Patel Mitesh B. 
Published: January 2021

An occurrence of Iphigenia stellata Blatter (Colchicaceae) is reported here as a floral addition to the state of Gujarat, India. A detailed description of the plant with coloured photographs and other relevant information have been provided.
Histopathological findings of infections caused by canine distemper virus, Trypanosoma cruzi, and other parasites in two free-ranging White-nosed Coatis Nasua narica (Carnivora: Procyonidae) from Costa Rica
Authors: Rojas-Jiménez Jorge , Morales-Acuña Juan A. , Argüello-Sáenz Milena , Acevedo-González Silvia E. , Yabsley Michael J. , Urbina-Villalobos Andrea 
Published: January 2021

Canine distemper virus (CDV) causes systemic infections and immunosuppression in carnivores, which subsequently makes animals highly susceptible to opportunistic infections. Although Trypanosoma cruzi infects procyonids, chagasic myocarditis in Coatis has not been reported in Central America. The aim of this study was to report the histopathological findings caused by canine distemper virus, T. cruzi, and other parasites in two free-ranging White-nosed Coatis Nasua narica found dead in a national park on the Pacific coast of Costa Rica. Heart, lung, tongue, liver, brain and spleen samples were subjected to macroscopic and microscopic examination. A mononuclear meningoencephalitis associated with intra-nuclear eosinophilic inclusion bodies consistent with canine distemper virus was observed in nervous tissue. Myocarditis and associated nests of amastigotes of T. cruzi were observed during microscopic examination in cardiac tissue, and in muscle from the tongue of both animals. Molecular analysis confirmed T. cruzi in formalin-fixed paraffin embedded cardiac tissues. The myocardial damage caused by the opportunistic infection due to T. cruzi in these individuals could be the result of a severe compromised immunological status associated to the CDV infection, and subsequent opportunistic polyparasitism described herein. To the authors knowledge this is the first report of chagasic myocarditis in free-ranging coatis from Central America.
Record of the world’s biggest pangolin? New observations of bodyweight and total body length of the Indian Pangolin Manis crassicaudata Gray, 1827 (Mammalia: Pholidota: Manidae) from Mannar District, Sri Lanka
Authors: Perera Priyan , Algewatta Hirusha Randimal , Vidanage Buddhika 
Published: January 2021

The Indian Pangolin Manis crassicaudata is one of the eight extant pangolin species in the world, occurring in the Indian subcontinent and is the solitary pangolin species recorded in Sri Lanka. Little is known about the intra-specific morphometric variations of the Indian Pangolin, largely due to the limited observations. In this note, we report the morphometrics of the largest Indian Pangolin recorded so far in its range, and consequently the largest pangolin ever to be recorded according to published information. These records along with observations from other range countries provide novel insights into the maximum growth of male Indian Pangolins.
Freshwater fishes of Cauvery Wildlife Sanctuary, Western Ghats of Karnataka, India
Authors: Sreenivasan Naren , Mahesh Neethi , Raghavan Rajeev 
Published: January 2021

The ichthyofauna of Cauvery Wildlife Sanctuary is comprised of 58 species belonging to 18 families and 44 genera of which close to 25% are endemic to the Western Ghats region, and eight are endemic to the Cauvery River system namely, Dawkinsia arulius, Dawkinsia rubrotinctus, Hypselobarbus dubius, H. micropogon, Kantaka brevidorsalis, Labeo kontius, Tor remadevii and Hemibagrus punctatus. Eight species found in Cauvery Wildlife Sanctuary are threatened, including two (Tor remadevii and Hemibagrus punctatus) listed as ‘Critically Endangered’, four species (Dawkinsia arulius, Hypselobarbus dubius, H. micropogon, and Silonia childreni) as ‘Endangered’ and two (Hyporhamphus xanthopterus and Wallago attu) as ‘Vulnerable’ on the IUCN Red List.
A new record of pyrenocarpous lichen to the Indian biota
Authors: Rajaprabu N. , Ponmurugan P. , Mishra Gaurav K. 
Published: January 2021

Pyrenula subglabrata (Nyl.) Müll. Arg. is reported as a new find to Indian lichen biota from Arunachal Pradesh and Tamil Nadu states. The species is found growing on smooth bark trees of both the regions.
Toward internationalization: A bibliometric analysis of the social
sciences in Mainland China from 1979 to 2018
Authors: Zhang Lin , Shang Yuanyuan , Huang Ying , Sivertsen Gunnar 
Published: January 2021

Abstract
The past 40 years have witnessed profound changes in the international competitiveness of Mainland China’s scientific research. Based on publication data from Chinese researchers in the Social Sciences Citation Index (SSCI) from the Web of Science (WoS), this study aims to provide a bird’s-eye view of how social science research in Mainland China has internationalized over the past four decades. The findings show that the number of social science articles published by Chinese authors in international journals has experienced a noticeable increase, and the collaboration networks of researchers from Mainland China have broadened, with the number of articles with a Chinese first author showing a strong upward trend. In addition, findings show that Chinese scholars are published in a wider range of journals, and there has been a steady increase in their appearance in higher impact journals (influenced in part by certain journals). Finally, different social science disciplines show various degrees of internationalization. This study provides a broad view from which to examine the internationalization process in Mainland China’s social science landscape in the last four decades, while also noting some of the possible explanations for these changes, thereby deepening our understanding of social science research stemming from the region.
A comprehensive analysis of the journal evaluation system in
China
Authors: Huang Ying , Li Ruinan , Zhang Lin , Sivertsen Gunnar 
Published: January 2021

Abstract
Journal evaluation systems reflect how new insights are critically reviewed and published, and the prestige and impact of a discipline’s journals is a key metric in many research assessment, performance evaluation, and funding systems. With the expansion of China’s research and innovation systems and its rise as a major contributor to global innovation, journal evaluation has become an especially important issue. In this paper, we first describe the history and background of journal evaluation in China and then systematically introduce and compare the most currently influential journal lists and indexing services. These are the Chinese Science Citation Database (CSCD), the Journal Partition Table (JPT), the AMI Comprehensive Evaluation Report (AMI), the Chinese S&T Journal Citation Report (CJCR), “A Guide to the Core Journals of China” (GCJC), the Chinese Social Sciences Citation Index (CSSCI), and the World Academic Journal Clout Index (WAJCI). Some other influential lists produced by government agencies, professional associations, and universities are also briefly introduced. Through the lens of these systems, we provide comprehensive coverage of the tradition and landscape of the journal evaluation system in China and the methods and practices of journal evaluation in China with some comparisons to how other countries assess and rank journals.
Large-scale comparison of bibliographic data sources: Scopus, Web of
Science, Dimensions, Crossref, and Microsoft Academic
Authors: Visser Martijn , van Eck Nees Jan , Waltman Ludo 
Published: January 2021

Abstract
We present a large-scale comparison of five multidisciplinary bibliographic data sources: Scopus, Web of Science, Dimensions, Crossref, and Microsoft Academic. The comparison considers scientific documents from the period 2008–2017 covered by these data sources. Scopus is compared in a pairwise manner with each of the other data sources. We first analyze differences between the data sources in the coverage of documents, focusing for instance on differences over time, differences per document type, and differences per discipline. We then study differences in the completeness and accuracy of citation links. Based on our analysis, we discuss the strengths and weaknesses of the different data sources. We emphasize the importance of combining a comprehensive coverage of the scientific literature with a flexible set of filters for making selections of the literature.
La production des actes de waqf ibadites et autres en Tunisie à l’ époque moderne
Authors: Merimi Mohamed , Meghnine Khaled , Mestaoui Soufien 
Published: January 2021

Résumé
L’ article vise à passer en revue et à comprendre la culture ibadite de la population de Djerba dans le domaine de la production des actes de waqf à l’ époque moderne. À l’ origine, les résidents de Djerba utilisaient des contrats de waqf oraux et coutumiers conclus au nom de la « congrégation des fidèles de la mosquée » et sous le titre du waqf général. Leurs contrats de waqf ont évolué dans de nombreuses et différentes directions. La majorité de ces contrats sont devenus écrits en raison de l’ influence du voisinage malékite dont la présence sur l’ île remonte à l’ époque hafside. Certains de ces contrats sont cependant restés coutumiers, et ils sont devenus des waqfs publics associés aux zaouïas, comme ce fut le cas avec les malékites. D’ autres ont été transférés de la coutume et de l’ oral à des documents écrits à caractère officiel agréé par le pouvoir judiciaire malékite. Les ibadites ont eu recours à produire des actes de waqf conformes aux valeurs de la science du témoin et à la jurisprudence malékite. La diaspora ibadite djerbienne, dont la relation sociale est régie par ses institutions du pouvoir local (niẓām al-ʿazzāba), a produit des actes qui respectent les valeurs de l’ école de jurisprudence malékite.
Medical Diplomacy and Iranian Foreign Policy
Authors: Dolatabadi Ali Bagheri , Kamrava Mehran 
Published: January 2021

Abstract
Despite numerous studies of Iran in recent decades, the country’s concerted efforts to expand its medical diplomacy have been largely overlooked by experts and observers alike. This is despite the fact that the Islamic Republic has sought to employ medical diplomacy as a viable tool for expanding its soft power for a number of years. Over the course of the last two decades, in fact, Iranian authorities and health professionals have considered their medical advances to greatly add value to the country’s overall diplomatic profile. This article examines three basic questions: first, how has Iran used medical diplomacy to increase its regional influence in the Middle East? second, what are the factors that have contributed to the country’s success in this area? And, third, what are likely to be the regional consequences of Iran’s enhanced medical diplomacy in the future? The answers to these questions will present an overall picture of the current and future depth and voracity of Iran’s soft power.
Study on chemical pattern recognition of Phoebe bournei wood based on gas chromatography/mass spectroscopy
Authors: Wang Tianshi , Liao Xiaoling , Ning Liping , Xu Xueju , Li Mei , Li Yingjian 
Published: January 2021

Abstract
The object of this study is the wood of Phoebe bournei (Hemsl.) Yang. Firstly, the macroscopic and microscopic structural characteristics of P. bournei wood were studied, and then the wood was compared with other species of the same genus. Through GC-MS technology, the volatile substance composition of P. bournei wood was studied, and the common volatile substance compositions were analyzed by using correlation analysis, principal component analysis (PCA), and orthogonal partial least square discriminant model analysis (OPLS-DA) models. The purpose of this study was to determine the significantly different components of P. bournei wood in comparison to three similar species in the same genus and explore whether these can be used as a chemical pattern recognition method for this wood. The results showed that 11 common components were found in all the P. bournei wood samples. Through the correlation analysis between the samples of P. bournei from different sources, they had a strong interrelation and high correlation coefficient. P. bournei wood could be initially distinguished from the wood of the other three similar species of the same genus by PCA. Through OPLS-DA modeling and calculation the classification effect of the model was more obvious. The variable information used to analyze the experimental model was more complete, and the model had a strong prediction ability. With the combination of the load diagram (S-plot) and variable contribution index (VIP), variable components were preliminarily screened, and then inter-group t-test and variable content analysis were conducted for the samples. The results show that the OPLS-DA model analysis of valerianol and agarspirol has obvious differences, which can be used to distinguish wood of P. bournei from three other tree species of the same genus.