bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics of vulnerable populations hospitalized and diagnosed with COVID-19 in Buenos Aires, Argentina
Authors: Yacobitti A. , Otero L. , Doldan Arrubarrena V. , Arano J. , Lage S. , Silberman M. , Zubieta M. , Erbetta I. , Danei P. , Baeck G. , Vallejos V. , Cavalli F. , Calderón N. , Di Gregorio M. , Hernandez V. , Bruno D. , Rodera B. , Macherett I. , Parisi M. , Gallastegui M. , Paz A. , Bernardi R. , Azcárate S. , Hraste A. , Caridi I. , Boechi L. , Salgado P. , Kochen S. 
Published: May 2021

AbstractThere is not in Argentina publications regarding the presentation of patients with COVID-19 requiring hospitalized and emergency care in vulnerable populations (lower incomes and less education tend at greater risk for poor health status and healthcare access), and it has few reports in developing countries. The objective is to determine whether in the care of vulnerable patients, to succeed against COVID-19, multiple public health tools and interventions will be needed to minimize morbidity and mortality. The study is a prospective cohort investigation of patients with lab-confirmed COVID-19, who required to any of the Health Centers response from April 8, 2020, to August 18, 2020. In Buenos Aires Metropolitan Area (AMBA), April 8, 2020 the virus was identified in patients hospitalized in the "Southeast Network" (SN), AMBA. SN covering an area of 661 square kilometers, with 1.8 million inhabitants residing in urban, and rural areas. A total of 14 health centers with different levels of care complexity provide care to patients in the region. The information of each patient with COVID-19 evaluated by SN, was incorporated in an Epidemiological Dashboard. The investigation was designed and reported with consideration of observational studies in epidemiology. We describe the hospitals presentation and care of persons who required SN response and were ultimately diagnosed with COVID-19. From April 8, 2020, to August 18, 2020, were included 1495 patients with lab-confirmed COVID-19 in SN. A total of 58% patients were men, and the mean age (SD) was 48.9 (15.59) years. Eighty one percent patients with pre-existing diseases, most frequent hypertension and diabetes, but hypertension, chronic lung disease, and cardiovascular disease presented higher risk. A total of 13% were hospitalized in Intensive Therapy Unit. The mortality of the cohort was 9.77%. Mortality was higher for patients aged 65 or more (OR 5.09), and for those had some pre-existing disease (OR 2.61). Our observations are consistent with reports demonstrating older persons, and those with comorbidities have the highest risk of mortality related to COVID-19. However, unlike other reports from developed or some developing countries, the mortality in our study is lower. This finding may be related to age of our cohort is younger than other published. Also, the health system was able to respond to the demand.
Integrated pulse scope for tunable generation and intrinsic characterization of structured femtosecond laser
Authors: Huo Tiancheng , Qi Li , Chen Jason J. , Miao Yusi , Chen Zhongping 
Published: May 2021

AbstractNumerous techniques have been demonstrated for effective generation of orbital angular momentum-carrying radiation, but intracavity generation of continuously tunable pulses in the femtosecond regime remains challenging. Even if such a creation was realized, the generated pulses—like all pulses in reality—are complex and transitory objects that can only be comprehensively characterized via multidimensional spaces. An integrated lasing system that generates pulses while simultaneously quantifies them can achieve adaptive pulse tailoring. Here, we report a femtosecond pulse scope that unifies vector vortex mode-locked lasing and vectorial quantification. With intracavity-controlled Pancharatnam-Berry phase modulation, continuous and ergodic generation of spirally polarized states along a broadband higher-order Poincaré sphere was realized. By intrinsically coupling a two-dimensional polarization-sensitive time-scanning interferometer to the laser, multidimensional spatiotemporal features of the pulse were further visualized. The proposed methodology paves the way for design optimization of ultrafast optics by integrating complex femtosecond pulse generation and structural customization, facilitating its applications in optical physics research and laser-based manufacturing.
Color-dependent changes in humans during a verbal fluency task under colored light exposure assessed by SPA-fNIRS
Authors: Zohdi Hamoon , Egli Rahel , Guthruf Daniel , Scholkmann Felix , Wolf Ursula 
Published: May 2021

AbstractLight evokes robust visual and nonvisual physiological and psychological effects in humans, such as emotional and behavioral responses, as well as changes in cognitive brain activity and performance. The aim of this study was to investigate how colored light exposure (CLE) and a verbal fluency task (VFT) interact and affect cerebral hemodynamics, oxygenation, and systemic physiology as determined by systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS). 32 healthy adults (17 female, 15 male, age: 25.5 ± 4.3 years) were exposed to blue and red light for 9 min while performing a VFT. Before and after the CLE, subjects were in darkness. We found that this long-term CLE-VFT paradigm elicited distinct changes in the prefrontal cortex and in most systemic physiological parameters. The subjects’ performance depended significantly on the type of VFT and the sex of the subject. Compared to red light, blue evoked stronger responses in cerebral hemodynamics and oxygenation in the visual cortex. Color-dependent changes were evident in the recovery phase of several systemic physiological parameters. This study showed that the CLE has effects that endure at least 15 min after cessation of the CLE. This underlines the importance of considering the persistent influence of colored light on brain function, cognition, and systemic physiology in everyday life.
Lives versus Livelihoods? Perceived economic risk has a stronger association with support for COVID-19 preventive measures than perceived health risk
Authors: Nisa Claudia F. , Bélanger Jocelyn J. , Faller Daiane G. , Buttrick Nicholas R. , Mierau Jochen O. , Austin Maura M. K. , Schumpe Birga M. , Sasin Edyta M. , Agostini Maximilian , Gützkow Ben , Kreienkamp Jannis , Abakoumkin Georgios , Abdul Khaiyom Jamilah Hanum , Ahmedi Vjollca , Akkas Handan , Almenara Carlos A. , Atta Mohsin , Bagci Sabahat Cigdem , Basel Sima , Kida Edona Berisha , Bernardo Allan B. I. , Chobthamkit Phatthanakit , Choi Hoon-Seok , Cristea Mioara , Csaba Sára , Damnjanović Kaja , Danyliuk Ivan , Dash Arobindu , Di Santo Daniela , Douglas Karen M. , Enea Violeta , Fitzsimons Gavan , Gheorghiu Alexandra , Gómez Ángel , Grzymala-Moszczynska Joanna , Hamaidia Ali , Han Qing , Helmy Mai , Hudiyana Joevarian , Jeronimus Bertus F. , Jiang Ding-Yu , Jovanović Veljko , Kamenov Željka , Kende Anna , Keng Shian-Ling , Kieu Tra Thi Thanh , Koc Yasin , Kovyazina Kamila , Kozytska Inna , Krause Joshua , Kruglanski Arie W. , Kurapov Anton , Kutlaca Maja , Lantos Nóra Anna , Lemay Edward P. , Lesmana Cokorda Bagus Jaya , Louis Winnifred R. , Lueders Adrian , Malik Najma Iqbal , Martinez Anton , McCabe Kira O. , Mehulić Jasmina , Milla Mirra Noor , Mohammed Idris , Molinario Erica , Moyano Manuel , Muhammad Hayat , Mula Silvana , Muluk Hamdi , Myroniuk Solomiia , Najafi Reza , Nyúl Boglárka , O’Keefe Paul A. , Osuna Jose Javier Olivas , Osin Evgeny N. , Park Joonha , Pica Gennaro , Pierro Antonio , Rees Jonas , Reitsema Anne Margit , Resta Elena , Rullo Marika , Ryan Michelle K. , Samekin Adil , Santtila Pekka , Selim Heyla A. , Stanton Michael Vicente , Sultana Samiah , Sutton Robbie M. , Tseliou Eleftheria , Utsugi Akira , van Breen Jolien Anne , Van Lissa Caspar J. , Van Veen Kees , vanDellen Michelle R. , Vázquez Alexandra , Wollast Robin , Yeung Victoria Wai-lan , Zand Somayeh , Žeželj Iris Lav , Zheng Bang , Zick Andreas , Zúñiga Claudia , Leander N. Pontus 
Published: May 2021

AbstractThis paper examines whether compliance with COVID-19 mitigation measures is motivated by wanting to save lives or save the economy (or both), and which implications this carries to fight the pandemic. National representative samples were collected from 24 countries (N = 25,435). The main predictors were (1) perceived risk to contract coronavirus, (2) perceived risk to suffer economic losses due to coronavirus, and (3) their interaction effect. Individual and country-level variables were added as covariates in multilevel regression models. We examined compliance with various preventive health behaviors and support for strict containment policies. Results show that perceived economic risk consistently predicted mitigation behavior and policy support—and its effects were positive. Perceived health risk had mixed effects. Only two significant interactions between health and economic risk were identified—both positive.
Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT
Authors: Kim Hyery , You Seungwon , Park Yoomi , Choi Jung Yoon , Ma Youngeun , Hong Kyung Tak , Koh Kyung-Nam , Yun Sunmin , Lee Kye Hwa , Shin Hee Young , Lee Suehyun , Yoo Keon Hee , Im Ho Joon , Kang Hyoung Jin , Kim Ju Han 
Published: May 2021

AbstractNUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite the impact of homozygous CRIM1 on thiopurine toxicity, several patients with wild-type NUDT15, TPMT, and CRIM1 experience thiopurine toxicity, therapeutic failure, and relapse of acute lymphoblastic leukemia (ALL). Novel pharmacogenetic interactions associated with thiopurine intolerance from hematological toxicities were investigated using whole-exome sequencing for last-cycle 6-mercaptopurine dose intensity percentages (DIP) tolerated by pediatric ALL patients (N = 320). IL6 rs13306435 carriers (N = 19) exhibited significantly lower DIP (48.0 ± 27.3%) than non-carriers (N = 209, 69.9 ± 29.0%; p = 0.0016 and 0.0028 by t test and multiple linear regression, respectively). Among 19 carriers, 7 with both heterozygous IL6 rs13306435 and CRIM1 rs3821169 showed significantly decreased DIP (24.7 ± 8.9%) than those with IL6 (N = 12, 61.6 ± 25.1%) or CRIM1 (N = 94, 68.1 ± 28.4%) variants. IL6 and CRIM1 variants showed marked inter-ethnic variability. Four-gene-interplay models revealed the best odds ratio (8.06) and potential population impact [relative risk (5.73), population attributable fraction (58%), number needed to treat (3.67), and number needed to genotype (12.50)]. Interplay between IL6 rs13306435 and CRIM1 rs3821169 was suggested as an independent and/or additive genetic determinant of thiopurine intolerance beyond NUDT15 and TPMT in pediatric ALL.
Ability of neural network cells in learning teacher motivation scale and prediction of motivation with fuzzy logic system
Authors: Pourtousi Zahra , Khalijian Sadaf , Ghanizadeh Afsaneh , Babanezhad Meisam , Nakhjiri Ali Taghvaie , Marjani Azam , Shirazian Saeed 
Published: May 2021

AbstractWe employed a new approach in the field of social sciences or psychological aspects of teaching besides using a very common software package that is Statistical Package for the Social Sciences (SPSS). Artificial intelligence (AI) is a new domain that the methods of its data analysis could provide the researchers with new insights for their research studies and more innovative ways to analyze their data or verify the data with this method. Also, a very significant element in teaching is teacher motivation that is the trigger that pushes the teachers forward, depending on some internal and external factors. In the current study, seven research questions were designed to explore different aspects of teacher motivation, and they were analyzed via SPSS. The current study also compared the results by using an adaptive neuro-fuzzy inference system (ANFIS). Due to the similarity of ANFIS to humans' brain intelligence, the results of the current study could be similar to humans regarding what happens in reality. To do so, the researchers used the validated teacher motivation scale (TMS) and asked participants to fill the questionnaire, and analyzed the results. When the inputs were added to the ANFIS system, the model indicated a high accuracy and prediction capability. The findings also illustrated the importance of the tuning model parameters for the ANFIS method to build up the AI model with a high repeatability level. The differences between the results and conclusions are discussed in detail in the article.
Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis
Authors: Stec Małgorzata , Seweryn Michał , Korkosz Mariusz , Guła Zofia , Szatanek Rafał , Węglarczyk Kazimierz , Rutkowska-Zapała Magdalena , Lenart Marzena , Czepiel Marcin , Czyż Jarosław , Baran Jarosław , Gruca Anna , Wojnar-Lasoń Kamila , Wołkow Paweł , Siedlar Maciej 
Published: May 2021

AbstractSpondyloarthritis (SpA) is characterized by chronic inflammation and structural damage involving spine and peripheral joints. Monocytes, as part of innate immune system, following migration into affected tissue, may play a role in the pathogenesis of SpA. Here, potential associations between osteogenesis-linked gene expression profile in particular monocyte subpopulations and clinical signs of SpA were investigated. The 20 patients with axial and 16 with peripheral SpA were enrolled in the study. Monocyte subpopulations (classical—CD14++CD16−, intermediate—CD14++CD16+ and non-classical—CD14+CD16++) were isolated from blood using flow cytometry and gene expression analysis was performed using real-time PCR method and TaqMan Array, Human Osteogenesis, Fast 96-well plates. Next, the characteristic clinical features shared by axial and peripheral SpA were analyzed in the context of the expression of selected genes in the three subpopulations of monocytes. We demonstrated that expression of VEGFA in classical and MSX2 in non-classical monocytes were associated with the number of swollen and painful peripheral joints of SpA patients. We conclude that monocytes may contribute to the development of peripheral arthritis in SpA patients. This might be possible through subpopulation specific effects, linking number of inflamed joints with expression of VEGFA in classical monocytes and MSX2 in non-classical monocytes.
Metabolomic and phenotypic implications of the application of fertilization products containing microcontaminants in lettuce (Lactuca sativa)
Authors: Matamoros Víctor , Rendón-Mera Alicia María , Piña Benjamí , Tadić Đorđe , Cañameras Núria , Carazo Nuria , Bayona J. M. 
Published: May 2021

AbstractCultivation practice using organic amendments is plausible to ensure global food security. However, plant abiotic stress due to the presence of metals and organic microcontaminants (OMCs) in fertilization products cannot be overlooked. In this study, we monitored lettuce metabolism and phenotypic response following the application of either sewage sludge (SS), the organic fraction of municipal solid waste, swine manure (SM), chemical fertilizers (CF), or no amendment (C) in a greenhouse facility. The experimental set-up consisted of five treatments with five replicates (25 experimental units randomly distributed). All fertilizers were supplied at the equivalent agronomic total nitrogen dose, but the occurrence of trace metals and/or OMCs was greater in the SS and SM than the rest. Non-target metabolomic analysis (high-resolution mass spectrometry coupled with partial least squares regression) identified more than 300 plant metabolites (amino acids, organic acids, sugar alcohols, and sugars), 55 of which showed significant changes in their relative abundances depending on the type of amendment. Functional analysis indicated that the use of CF or SS increased the levels of metabolites involved in carbohydrate and nitrogen metabolism. Therefore, although SS and SM fertilizers had a greater presence of heavy metals and/or OMCs, our results indicate that they did not induce measurable adverse effects in the lettuce phenotype or metabolism. Metabolic changes between fertilizers (CF and SS vs. C and SM) were mainly due to nitrogen availability.
RETRACTED ARTICLE: nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse
Authors: D’Angelo Chiara , Costantini Erica , Salvador Nieves , Marchioni Michele , Di Nicola Marta , Greig Nigel H. , Reale Marcella 
Published: May 2021

AbstractAn evaluation of the APPswe/PS1dE9 transgenic AD mouse, presenting with the toxic Aβ1-42 deposition found in human AD, allowed us to characterize time-dependent changes in inflammatory and cholinergic markers present in AD. Astrogliosis was observed in cortex and hippocampus, with cellular loss occurring in the same areas in which Aβ plaques were present. In this setting, we found early significantly elevated levels of IL-1β and TNFα gene expression; with the hippocampus showing the highest IL-1β expression. To investigate the cholinergic anti-inflammatory pathway, the expression of nicotinic receptors (nAChRs) and cholinesterase enzymes also was evaluated. The anti-inflammatory nAChRα7, α4, and β2 were particularly increased at 6 months of age in the hippocampus, potentially as a strategy to counteract Aβ deposition and the ensuing inflammatory state. A time-dependent subunit switch to the α3β4 type occurred. Whether α3, β4 subunits have a pro-inflammatory or an inhibitory effect on ACh stimulation remains speculative. Aβ1-42 deposition, neuronal loss and increased astrocytes were detected, and a time-dependent change in components of the cholinergic anti-inflammatory pathway were observed. A greater understanding of time-dependent Aβ/nAChRs interactions may aid in defining new therapeutic strategies and novel molecular targets.
Longitudinal studies support the safety and ethics of virtual reality suicide as a research method
Authors: Huang Xieyining , Funsch Kensie M. , Park Esther C. , Conway Paul , Franklin Joseph C. , Ribeiro Jessica D. 
Published: May 2021

AbstractMany have expressed concerns about the safety and ethics of conducting suicide research, especially intense suicide research methods that expose participants to graphic depictions of suicidality. We conducted two studies to evaluate the effects of one such method called virtual reality (VR) suicide. Study 1 tested the effects of VR suicide exposure over the course of one month in participants with (n = 56) and without a history of suicidality (n = 50). Study 2 exposed some participants to VR suicide scenarios (n = 79) and others to control scenarios (n = 80). Participants were invited to complete a follow-up assessment after an average of 2 years. For both studies, the presence of suicidality post exposure was the primary outcome, with closely related constructs (e.g., capability for suicide, agitation) as secondary outcomes. Study 1 found no pre-post increases in suicidality or related variables, but revealed several significant decreases associated with small to medium effect sizes in suicide-related constructs. In Study 2, VR suicide exposure did not cause any significant increases in suicidality or related variables. Together with prior research, these findings suggest that methods involving intense suicide stimuli appear safe and consistent with utilitarian ethics.
Surgical stress and metabolic response after totally laparoscopic right colectomy
Authors: Milone Marco , Desiderio Antonella , Velotti Nunzio , Manigrasso Michele , Vertaldi Sara , Bracale Umberto , D’Ambra Michele , Servillo Giuseppe , De Simone Giuseppe , De Palma Fatima Domenica Elisa , Perruolo Giuseppe , Raciti Gregory Alexander , Miele Claudia , Beguinot Francesco , De Palma Giovanni Domenico 
Published: May 2021

AbstractNo clear consensus on the need to perform an intracorporeal anastomosis (IA) after laparoscopic right colectomy is currently available. One of the potential benefits of intracorporeal anastomosis may be a reduction in surgical stress. Herein, we evaluated the surgical stress response and the metabolic response in patients who underwent right colonic resection for colon cancer. Fifty-nine patients who underwent laparoscopic resection for right colon cancer were randomized to receive an intracorporeal or an extracorporeal anastomosis (EA). Data including demographics (age, sex, BMI and ASA score), pathological (AJCC tumour stage and tumour localization) and surgical results were recorded. Moreover, to determine the levels of the inflammatory response, mediators, such as C-reactive protein (CRP), tumour necrosis factor (TNF), interleukin 1β (IL-1β), IL-6, IL-10, and IL-13, were evaluated. Similarly, cortisol and insulin levels were evaluated as hormonal responses to surgical stress. We found that the proinflammatory mediator IL-6, CRP, TNF and IL-1β levels, were significantly reduced in IA compared to EA. Concurrently, an improved profile of the anti-inflammatory cytokines IL-10 and IL-13 was observed in the IA group. Relative to the hormone response to surgical stress, cortisol was increased in patients who underwent EA, while insulin was reduced in the EA group. Based on these results, surgical stress and metabolic response to IA justify advocating the adoption of a totally laparoscopic approach when performing a right colectomy for cancer.This trial is registered on ClinicalTrials.gov (ID: NCT03422588).
Towards a neutron and X-ray reflectometry environment for the study of solid–liquid interfaces under shear
Authors: Armstrong Alexander J. , McCoy Thomas M. , Welbourn Rebecca J. L. , Barker Robert , Rawle Jonathan L. , Cattoz Beatrice , Dowding Peter J. , Routh Alexander F. 
Published: May 2021

AbstractA novel neutron and X-ray reflectometry sample environment is presented for the study of surface-active molecules at solid–liquid interfaces under shear. Neutron reflectometry was successfully used to characterise the iron oxide–dodecane interface at a shear rate of $$7.0\times {}10^{2}$$

7.0
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10
2

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1

using a combination of conventional reflectometry theory coupled with the summation of reflected intensities to describe reflectivity from thicker films. Additionally, the structure adopted by glycerol monooleate (GMO), an Organic Friction Modifier, when adsorbed at the iron oxide–dodecane interface at a shear rate of $$7.0\times {}10^{2}$$

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was studied. It was found that GMO forms a surface layer that appears unaltered by the effect of shear, where the thickness of the GMO layer was found to be $$24.3^{+9.9}_{-10.2}$$

24
.

3

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10.2

+
9.9

Å under direct shear at $$7.0\times {}10^{2}$$

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1

and $$25.8^{+4.4}_{-5.2}$$

25
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8

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+
4.4

Å when not directly under shear. Finally, a model to analyse X-ray reflectometry data collected with the sample environment is also described and applied to data collected at $$3.0\times {}10^{3}$$

3.0
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10
3

$$\hbox {s}^{-1}$$

s

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1

.