bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing patients with suspected postpartum retained products of conception using a novel sonographic classification
Authors: Levinsohn-Tavor Orna , Sharon Nataly Zilberman , Feldman Noa , Svirsky Ran , Smorgick Noam , Nir-Yoffe Arava , Maymon Ron 
Published: February 2021

Background Suspicion of retained products of conception (RPOC) often arises after delivery and still poses a diagnostic and management challenge. Purpose To prospectively evaluate a sonographic classification for the management of patients with suspected RPOC after delivery. Material and Methods Based on grayscale and Doppler ultrasound parameters, patients were classified into high, moderate, or low probability of RPOC. For the low and moderate probability groups, an ultrasound follow-up at the end of the puerperium was recommended. For the high probability group, a follow-up examination was conducted 10–14 days after the first ultrasound, and patients with persistent high probability findings were referred for surgical intervention. Results The sample was composed of 215 patients at risk of RPOC. Of these, 100, 93, and 22 patients were classified as having a low, moderate, or high probability of RPOC, respectively. Rates of RPOC were 55%, 2%, and 2% in the high, moderate, and low probability categories, respectively. When the categorization was based on the most recent ultrasound obtained during the puerperium, the adjusted RPOC prevalence rates were 71% in the high, 6% in the moderate, and 0% in the low probability groups. Conclusion This study confirms the effectiveness of our sonographic classification for managing patients with suspected RPOC after delivery. In all three categories, it is recommended to adhere to a conservative management protocol in clinically stable women until the end of the puerperium. This approach provides good predictability for RPOC and can reduce unnecessary surgical interventions.
Arthroscopic Side-to-Side Repair of Massive Rotator Cuff Tears Maintains Adequate Functional Improvement at 12 to 14 Years’ Follow-up
Authors: Merlet Marie Caroline , Guinet Virginie , Rousseau Thomas , van Rooij Floris , Saffarini Mo , Dujardin Franck , Courage Olivier 
Published: February 2021

Background: Rotator cuff tears are common shoulder injuries that often cause pain and loss of function. Nonanatomic side-to-side techniques facilitate repair by minimizing tensions within tendons to improve healing and optimize the thickness of sutured tissues. Purpose/Hypothesis: The purpose was to evaluate long-term clinical and radiographic outcomes of arthroscopic side-to-side repair of massive rotator cuff tears (mRCTs). The hypothesis was that, at a minimum follow-up of 12 years, arthroscopic side-to-side repair maintains clinically important improvements. Study Design: Case series; Level of evidence, 4. Methods: The authors reviewed records of all patients who underwent arthroscopic repair of mRCTs over 2 consecutive years. A total of 30 adult patients met the eligibility criteria and underwent side-to-side repair. Patients were evaluated clinically using the Constant score (CS) and ultrasound to assess retears at 3 timepoints after surgery: 2 to 4 years, 5 to 7 years, and 12 to 14 years. Results: At first follow-up (3.2 ± 0.5 years), all 30 patients had clinical and ultrasound assessment, which revealed 13 retears (43%). At second follow-up (6.2 ± 0.5 years), all 30 patients had clinical and ultrasound assessment, which revealed 2 new retears (total 50%). At final follow-up (13.0 ± 0.7 years), only 21 patients had clinical assessment (1 died and 8 could not be reached), and only 19 patients had ultrasound assessment, which revealed 6 new retears (total 79%). Both absolute CS and age-/sex-adjusted CS improved significantly from baseline values at first follow-up (73.5 and 96.6, respectively), and remained stable at second follow-up (69.0 and 91.9, respectively), and final follow-up (64.4 and 87.0, respectively). Compared to shoulders with intact repairs, those with retears tended to have lower absolute CS at all follow-up visits, although differences were not statistically significant. Conclusion: Patients with mRCTs maintain satisfactory clinical scores at 12 to 14 years after arthroscopic side-to-side repair despite a high incidence of retears. Repair is a safe and effective treatment for mRCTs, providing a less invasive and less complex alternative to reverse shoulder arthroplasty and tendon transfer procedures.
An inhibitor of Krüppel-like factor 5 suppresses peritoneal fibrosis in mice
Authors: Muta Kumiko , Nakazawa Yuka , Obata Yoko , Inoue Hiro , Torigoe Kenta , Nakazawa Masayuki , Abe Katsushige , Furusu Akira , Miyazaki Masanobu , Yamamoto Kazuo , Koji Takehiko , Nishino Tomoya 
Published: February 2021

Back ground: Krüppel-like transcription factor 5 (KLF5) is a transcription factor regulating cell proliferation, angiogenesis and differentiation. It has been recently reported that Am80, a synthetic retinoic acid receptor α-specific agonist, inhibits the expression of KLF5. In the present study, we have examined the expression of KLF5 in fibrotic peritoneum induced by chlorhexidine gluconate (CG) in mouse and evaluated that Am80, as an inhibitor of KLF5, can reduce peritoneal fibrosis. Methods: Peritoneal fibrosis was induced by intraperitoneal injection of CG into peritoneal cavity of ICR mice. Am80 was administered orally for every day from the start of CG injection. Control mice received only a vehicle (0.5% carboxymethylcellulose solution). After 3 weeks of treatment, peritoneal equilibration test (PET) was performed and peritoneal tissues were examined by immunohistochemistry. Results: The expression of KLF5 was less found in the peritoneal tissue of control mice, while KLF5 was expressed in the thickened submesothelial area of CG-injected mice receiving the vehicle. Am80 treatment reduced KLF5 expression and remarkably attenuated peritoneal thickening, accompanied with the reduction of type III collagen expression. The numbers of transforming growth factor β-positive cells, α-smooth muscle actin-positive cells and infiltrating macrophages were significantly decreased in Am80-treated group. PET revealed the increased peritoneal permeability in CG mice, whereas Am80 administration significantly improved the peritoneal high permeability state. Conclusions: These results indicate the involvement of KLF5 in the progression of experimental peritoneal fibrosis and suggest that Am80 may be potentially useful for the prevention of peritoneal fibrosis through inhibition of KLF5 expression.
Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19
Authors: Bravaccini Sara , Fonzi Eugenio , Tebaldi Michela , Angeli Davide , Martinelli Giovanni , Nicolini Fabio , Parrella Paola , Mazza Massimiliano 
Published: February 2021

Translational Relevance No prophylactic treatments for COVID-19 have been clearly proven and found. In this pandemic context, cancer patients constitute a particularly fragile population that would benefit the best from such treatments, a present unmet need. TMPRSS2 is essential for COVID-19 replication cycle and it is under androgen control. Estrogen and androgen receptor dependent cues converge on TMPRSS2 regulation through different mechanisms of action that can be blocked by the use of hormonal therapies. We believe that there is enough body of evidence to foresee a prophylactic use of hormonal therapies against COVID-19 and this hypothesis can be easily tested on cohorts of breast and prostate cancer patients who follow those regimens. In case of pandemic, if the protective effect of hormonal therapies will be proven on cancer patients, the use of specific hormonal therapies could be extended to other oncological groups and to healthy individuals to decrease the overall risk of infection by SARS-CoV-2. Given the COVID-19 coronavirus emergency, a special focus is needed on the impact of this rapidly spreading viral infection on cancer patients. Androgen receptor (AR) signaling in the transmembrane protease serine 2 (TMPRSS2) regulation is emerging as an important determinant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility. In our study, we analyzed AR and TMPRSS2 expression in 17,352 normal and 9,556 cancer tissues from public repositories and stratified data according to sex and age. The emerging picture is that some patient groups may be particularly susceptible to SARS-CoV-2 infection and may benefit from antiandrogen- or tamoxifen-based therapies. These findings are relevant to choose proper treatments in order to protect cancer patients from concomitant SARS-CoV-2 contagion and related symptoms and put forward the idea that hormonal therapies could be used as prophylactic agents against COVID-19.
Design and stability of pediatric oral formulation of imatinib
Authors: Hinterlang Mélanie , Gendron Amandine , Fleury Thomas , Rieutord André , Vrana Anastasia , Schlatter Joël , Annereau Maxime 
Published: February 2021

Background Imatinib is a protein-tyrosine kinase inhibitor which is currently only commercially available as a tablet dosage form in the strength of 100mg and 400mg. The elaboration of new oral liquid formulations is suitable in pediatrics and for patients who have difficulties to swallow, notably in the absence of commercial forms. This enables the adaptation of dosage and secure the administration. Objectives The formulation of an oral pediatric solution of imatinib at a concentration of 30 mg/mL and the evaluation of its stability for the treatment of pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia. Methods The physicochemical stability parameters: appearance, pH, osmolality, and drug content of formulation were evaluated for 30 days when stored at 2–8°C. Concentration of solution was measured with a validated method using high performance liquid chromatography (HPLC) coupled with an absorbance UV detector. Equally, microbiological stability was performed. Results The remaining imatinib concentration was at least 95% of the initial concentration after 30 days stored in fridge temperature. No changes were observed regarding the physical properties of the formulation during the study period. Conclusions The stability study showed that the imatinib oral solution at a concentration of 30 mg/mL provides an alternative option at the commercial tablet dosage forms for pediatric patients and patients who have difficulties to swallow.
Relationships between resilience and quality of life in parents of children with cancer
Authors: Luo Y. H. , Li W. H. C. , Cheung A. T. , Ho L. L. K. , Xia W. , He X. L. , Zhang J. P. , Chung J. O. K. 
Published: February 2021

A child suffering from cancer can be considerably stressful for parents, exerting a negative impact on their psychological well-being and quality of life. This study explored the relationships between resilience and quality of life in parents of children with cancer. We recruited 146 parents of children with cancer in two tertiary hospitals in mainland China. The results revealed that greater parental resilience was associated with better quality of life. It is essential to develop interventions that can enhance resilience for parents of children with cancer, thereby improving their quality of life. ClinicalTrials.gov ID: NCT03631485
Impact of home visits to pregnant women and their spouses on gender norms and dynamics in Bauchi State, Nigeria: Narratives from visited men and women
Authors: Mudi Hadiza , Dutse Umar , Belaid Loubna , Ansari Umaira , Omer Khalid , Gidado Yagana , Baba Muhd Chadi , Mahdi Amina , Andersson Neil , Cockcroft Anne 
Published: February 2021

Background: Maternal and newborn child health are priority concerns in Bauchi State, northern Nigeria. Increased male involvement in reproductive health is recommended by the World Health Organization. A trial of a program of universal home visits to pregnant women and their spouses, with an intention to increase male involvement in pregnancy and childbirth, showed improvements in actionable risk factors and in maternal morbidity. We used a narrative technique to explore experiences of the visits and their effect on gender roles and dynamics within the households. Methods: Trained fieldworkers collected narratives of change from 23 visited women and 21 visited men. After translation of the stories into English, we conducted an inductive thematic analysis to examine the impact of the visits on gender norms and dynamics. Results: The analysis indicated that the visits improved men’s support for antenatal care, immunization, and seeking help for danger signs, increased spousal communication, and led to changes in perceptions about gender violence and promoted non-violent gender relationships. However, although some stories described increased spousal communication, they did not mention that this translated into shared decision-making or increased autonomy for women. Many of the men’s stories described a continuing paternalistic, male-dominant position in decision-making. Conclusions: Few studies have examined the gender-transformative potential of interventions to promote male involvement in reproductive health; our analysis provides some initial insights into this.
Peoples’ experiences of painful diabetic neuropathy: are pain management programmes appropriate?
Authors: Davies Ben , Cramp Fiona , Gauntlett-Gilbert Jeremy , McCabe Candida S 
Published: February 2021

Objective: Painful diabetic neuropathy (PDN) is a painful complication of diabetes. This study aimed to explore: (1) strategies used by participants to manage impacts of PDN and (2) their perspectives on whether strategies from pain management programmes (PMPs) had applicability for PDN. Design: Participants were recruited through local National Health Service (NHS) diabetes and PDN clinics, and nationally from a diabetes support charity. One-to-one interviews were conducted. The transcribed data were analysed using inductive thematic analysis. Results: Twenty-three people were interviewed who had PDN symptoms for mean 10 years. Four themes emerged from the data: seeking help and advice, pragmatic approach to management, perspectives on physical activity and perspectives on psychological coping strategies. Conclusion: Some participants were open to the strategies advised by PMP strategies. There were also strong opinions that no exercise or psychological approach could help with diabetes-related pain. It is possible PMPs as currently delivered need to be adapted to maximise engagement from people with PDN. Research is required to understand the healthcare priorities of people with PDN and whether these priorities can be mapped to existing management strategies.
Biomechanical Analysis of the Tuning Fork Plate Versus Dual Pelvic Screws in a Sacrectomy Model: A Finite Element Study
Authors: Joukar Amin , Mehta Jwalant , Goel Vijay K. , Marks David S. 
Published: February 2021

Study Design: To evaluate the mechanical effectiveness of “tuning fork” plate fixation system by comparing with dual iliac screw fixation under different spinal motion through finite element analysis (FEA). Objective: Lumbosacral deficiencies occur from birth defects or following destruction by tumors. The objective of this study was to evaluate the mechanical effectiveness of the tuning fork plate compared to dual iliac screw system which is the gold standard fixation in treating lumbosacral deficiencies. This is an innovative fixation device for treating lumbosacral deficiencies. Methods: The deficiency model was prepared using a previously developed and validated finite element T10-pelvis model. To create the lumbo-sacral deficiency the segments between L3 and sacrum were removed from the model. The model was then instrumented from T10 to L2 segments and the ilium using either the tuning fork plate or a dual iliac screw construct. With the ilium fixed, the T10 vertebrae was subjected to 10 Nm moment and 400 N follower load to simulate spinal motions. Range of motion (ROM) of spine and stresses on the instrumentation were calculated for 2 fixation devices and compared with each other. Results: The 2 fixation systems demonstrate a comparable motion reduction in all loading modes. Stress values were higher in the dual iliac screw constructs compared with the tuning fork plate fixation system. The factor of safety of the tuning fork plate device was higher than the dual iliac screw fixation by 50%. Conclusions: Both fixation devices had similar performance in motion reduction at spine levels. However, based on predicted implant stresses there were less chances of implant failure in the fork plate fixation, compared to the dual iliac screw system.
SARS-CoV-2 tropism: what urologists need to know
Authors: Desouky Elsayed 
Published: February 2021

Abstract
Background
Apart from viral sexually transmitted diseases, viral infections in urology are not common and likely to be underreported. Initially, COVID-19 was thought to be only affecting our practice indirectly through reducing elective work that almost came to a stop. However, recent upcoming reports show that urologists can get involved far beyond that.

Main body
Genitourinary tract can be directly affected based on the SARS-CoV-2 virus organotropism. The aim of this article is to present a comprehensive review of the data available and to highlight any possible similarity with the few known viral infections involving genitourinary organs with regard to its pathophysiologic impact.

Conclusion
Urologists need to extrapolate their experience with viral infections in the urinary tract so as to be able to manage such possible COVID infections and its short- and long-term consequences.
Two-year follow-up after holmium laser enucleation of the prostate and bipolar transurethral resection of the prostate: a prospective randomized study
Authors: El-Hawy Mamdouh M. , Eldakhakhny Amr , AbdEllatif Ahmed , Salem Emad A. , Ragab Ahmed , Elsharkawy Mostafa S. , Abdelghani Mostafa M. , Alshara Luay , Hasanein Mohamed G. , Ismail Ahmed H. , Ismail Ebrahim M. , Hassan Mohamed A. , Ali Ahmed I. 
Published: February 2021

Abstract
Background
Different treatment options are available for the management of BPH. Our study aimed to compare the surgical outcomes of a holmium laser enucleation of the prostate (HoLEP) and a bipolar transurethral resection of the prostate (Bipolar-TURP) after 2 years.

Methods
Our prospective randomized study included 114 patients: 55 patients underwent HoLEP procedure and 59 patients underwent bipolar TURP procedure. All patients underwent a complete preoperative assessment and a physical examination. The postoperative follow-up data included Q max and IPSS recordings at 1, 3, 6, 12, and 24 months and PVR urinary volume recordings at 6 and 12 months. Any postoperative complications were also recorded.

Results
There were no statistically significant differences between both groups regarding IPSS and Q max scores at one and 24 months postoperative. Also, there were no statistically significant differences between both groups regarding postoperative PVR at 6 and 12 months. One patient in the HoLEP group developed total incontinence after surgery.

Conclusion
Our study did not show a significant difference between HoLEP and bipolar TURP regarding postoperative Q max and IPSS scores at 24 months of follow-up.
Potential of blockchain approach on development and security of microbial databases
Authors: Mohammadipanah Fatemeh , Sajedi Hedieh 
Published: February 2021

Abstract
Approaches developed based on the blockchain concept can provides a framework for the realization of open science. The traditional centralized way of data collection and curation is a labor-intensive work that is often not updated. The fundamental contribution of developing blockchain format of microbial databases includes: 1. Scavenging the sparse data from different strain database; 2. Tracing a specific thread of access for the purpose of evaluation or even the forensic; 3. Mapping the microbial species diversity; 4. Enrichment of the taxonomic database with the biotechnological applications of the strains and 5. Data sharing with the transparent way of precedent recognition. The plausible applications of constructing microbial databases using blockchain technology is proposed in this paper. Nevertheless, the current challenges and constraints in the development of microbial databases using the blockchain module are discussed in this paper.

Graphical Abstract
tidyMicro: a pipeline for microbiome data analysis and visualization using the tidyverse in R
Authors: Carpenter Charlie M. , Frank Daniel N. , Williamson Kayla , Arbet Jaron , Wagner Brandie D. , Kechris Katerina , Kroehl Miranda E. 
Published: February 2021

Abstract
Background
The drive to understand how microbial communities interact with their environments has inspired innovations across many fields. The data generated from sequence-based analyses of microbial communities typically are of high dimensionality and can involve multiple data tables consisting of taxonomic or functional gene/pathway counts. Merging multiple high dimensional tables with study-related metadata can be challenging. Existing microbiome pipelines available in R have created their own data structures to manage this problem. However, these data structures may be unfamiliar to analysts new to microbiome data or R and do not allow for deviations from internal workflows. Existing analysis tools also focus primarily on community-level analyses and exploratory visualizations, as opposed to analyses of individual taxa.

Results
We developed the R package “tidyMicro” to serve as a more complete microbiome analysis pipeline. This open source software provides all of the essential tools available in other popular packages (e.g., management of sequence count tables, standard exploratory visualizations, and diversity inference tools) supplemented with multiple options for regression modelling (e.g., negative binomial, beta binomial, and/or rank based testing) and novel visualizations to improve interpretability (e.g., Rocky Mountain plots, longitudinal ordination plots). This comprehensive pipeline for microbiome analysis also maintains data structures familiar to R users to improve analysts’ control over workflow. A complete vignette is provided to aid new users in analysis workflow.

Conclusions
tidyMicro provides a reliable alternative to popular microbiome analysis packages in R. We provide standard tools as well as novel extensions on standard analyses to improve interpretability results while maintaining object malleability to encourage open source collaboration. The simple examples and full workflow from the package are reproducible and applicable to external data sets.