bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of CoFe2O4@Carboxymethylcellulose/HZSM-5 as a Novel Nano Magnetic Adsorbent for Metronidazole Removal: Isotherm, Kinetic and Thermodynamic Study
Authors: Nasiri Alireza , Heidari Mohammad Reza , Javid Neda , Yazdanpanah Ghazal 
Published: July 2021

Abstract
In this research CoFe2O4@CMC/ HZSM-5 synthesized in the presence of Carboxymethylcellulose as a biopolymer in the green conditions as a new nanomagnetic adsorbent for metronidazole removal from aqueous media. Physical and chemical structure of adsorbent was investigated by FTIR, FESEM, EDS, Mapping, TEM, XRD, VSM, BET and TGA techniques. The results indicated that 94% of the metronidazole concentration removed by CoFe2O4@CMC/HZSM-5 in the optimal conditions including pH 6, temperature 20oC, metronidazole concentration 50 mg/L, contact time 60 min and adsorbent dose 2 g/L. The resulting data from adsorption experimental experiments had better correlated with the Freundlich isotherm and pseudo-second order kinetic. Also, the thermodynamic study demonstrated that the adsorption process was an endothermic process and had a physical mechanism. As well as, the achieved findings demonstrated that following six adsorption runs, the adsorbent chemical structure had no change and the nanomagnetic adsorbent efficiency in the removal process had a slight decrease. CoFe2O4@CMC/HZSM-5 magnetic nanocomposite had effective adsorption capacity for metronidazole removal.
An Automated Solution for Controlling Random Fires on Coal Yards
Authors: Jayasuriya Jeevan Ramesh , Moser Irene , de Mel Ravi 
Published: July 2021

Abstract
In spite of recent moves to wean the world of fossil fuels, coal remains the main source of power in many countries. Coal yards are prone to spontaneous ignition, a problem faced in every country that stores or transports coal. Depending on the environment – temperature, ventilation, and the rank of the coal – heating and self-ignition can be a longer or shorter process, but the possibility can never be entirely dismissed. A plethora of studies have modelled this oxidation behaviour and proposed countermeasures. Most often, human intervention is necessary, which is both slow and dangerous for the firefighters involved. In this study, we propose to build a complete firefighting solution which is mounted on a number of towers sufficient to cover the area of an open coal yard, complete with redundancy. Each tower includes an inexpensive infrared detector, software to identify areas of elevated temperature, and a water dispenser. The heat detection software calculates the parameters to position the water dispenser so that it covers the area. A prototype has been built from inexpensive components to demonstrate the effectiveness at detecting and extinguishing arising fires. This work has been conducted in collaboration with the managers of the coal yard of a power plant.
Preclinical Evaluation of Podoplanin-Targeted Alpha-Radioimmunotherapy with The Novel Antibody NZ-16 for Malignant Mesothelioma
Authors: Sudo Hitomi , Tsuji Atsushi B , Sugyo Aya , Kaneko Mika K. , Kato Yukinari , Nagatsu Kotaro , Suzuki Hisashi , Higashi Tatsuya 
Published: July 2021

Abstract

Purpose This study aimed to evaluate the potential of podoplanin (PDPN)-targeted alpharadiotherapy (RIT) for treating malignant mesothelioma.Methods A newly developed anti-PDPN antibody, NZ-16, and a previous anti-PDPN antibody, NZ-12, were assessed. The in vitro properties of radiolabeled antibodies were evaluated by cell binding and competitive inhibition assays using PDPN-expressing NCI-H226 (H226) mesothelioma cells. The biodistribution of 111 In-labeled antibodies was studied in tumorbearing mice. Tumor volumes and body weights of mice treated with 90 Y- and 225 Ac-labeled NZ-16 were measured for 56 days. The absorbed doses were estimated on the basis of the biodistribution data. Pathologic analysis of tumors and organs was conducted.Results The radiolabeled NZ-16 specifically bound to H226 cells with higher affinity than NZ12. The biodistribution studies showed higher tumor uptake of radiolabeled NZ-16 compared with NZ-12. RIT with 225 Ac-labeled NZ-16 (11.1 and 18.5 kBq) had a significantly higher antitumor effect than RIT with 90 Y-labeled NZ-16 (3.7 MBq; P < 0.01). 225 Ac-labeled NZ-16 induced more necrosis compared with 90 Y-labeled NZ-16, but the Ki-67 index and apoptosis rate were similar. The estimated absorbed doses were expected to be tolerable in mice. Temporary body weight loss occurred, but recovered within several days. No visible damage to major organs was detected.Conclusion The novel anti-PDPN antibody NZ-16 was a more effective RIT agent than NZ12. Radiolabeled NZ-16, especially 225 Ac-labeled NZ-16, markedly suppressed tumor growth and prolonged survival without inducing severe adverse effects. RIT with radiolabeled NZ-16 is a promising therapeutic option for malignant mesothelioma.
Antiretroviral Therapy Switch Rates and Switching Patterns In 16,069 People Living with HIV: A Nationwide, Population-Based Study in Japan
Authors: Naito Toshio , Mori Hirotake , Fujibayashi Kazutoshi , Fukushima Shinichi , Yuda Mayumi , Fukui Nobuyuki , Tsukamoto Shotaro , Suzuki Mai , Goto-Hirano Keiko , Kuwatsuru Ryohei 
Published: July 2021

Abstract
To report the status of switch rates and time-to-switch of antiretroviral therapy (ART) regimens by evaluating anchor drug classes and common switching patterns in Japanese people living with human immunodeficiency virus (HIV, PLWH). This cross-sectional cohort study extracted data of 28,089 PLWH from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), which contains data representing the entire population of Japan. PLWH with first prescription records of ART administered between January 2011 and March 2019 were identified (n = 16,069). The median time-to-switch and switch rates of anchor drug classes were estimated by Kaplan-Meier analysis. Brookmeyer-Crowley and Greenwood methods were used to estimate 95% confidence intervals for switch rates and median days, respectively. Switch rates were compared between anchor drug classes by year using log-rank tests. A total of 3,108 (19·3%) PLWH switched anchor drug classes from first to second regimens. Switch rates increased continuously over eight years for non-nucleoside reverse transcriptase inhibitors (NNRTIs) (14·9%–65·5%) and protease inhibitors (PIs) (13·2%–67·7%), with median time-to-switch of 1,826 and 1,583 days, respectively. Integrase strand transfer inhibitors (INSTIs) maintained a low switch rate (3·0%–7·6%), precluding median-days calculation. The majority of patients treated initially with NNRTIs and PIs switched to INSTIs regardless of switching times (< 1 year: 67·3% and 85·9%, respectively; ≥1 year: 95·5% and 93·6%, respectively). The foremost switching strategies for first-to-second ART regimens are from NNRTI or PI to INSTI regimens that maintain low switch rates long term. INSTI HIV agents may be the most durable anchor drug class for PLWH receiving ART.
Phase 1 trial of apatinib combined with intensity-modulated radiotherapy in unresectable hepatocellular carcinoma
Authors: Wang Hongzhi , Zhu Xianggao , Zhao Yuting , Dong Dezuo , Li Lijuan , Cai Yong , Li Yongheng , Wang Weihu 
Published: July 2021

Abstract
Background

To investigate the maximum tolerated dose (MTD) of apatinib delivered during and after intensity-modulated radiotherapy (IMRT) for unresectable hepatocellular carcinoma (HCC).
Methods

Patients with unresectable HCC who were not eligible for radiofrequency ablation (RFA), transarterial chemoembolization (TACE), or residual/recurrent after the prior local treatment were enrolled. Patients were scheduled to be treated with IMRT at 50–60 Gy/25–30 fractions. Apatinib was administered concurrently with IMRT and continued after IMRT. In this study, we used a 3 + 3 dose-escalation design. Three dose levels of apatinib (250, 500, and 750mg) were designed. Grade 3 or more severe adverse events (AEs) were defined as dose-limiting toxicities (DLTs). The treatment response was calculated using the Modified Response Evaluation Criteria in Solid Tumour.
Results

Nine patients with Barcelona Clinic Liver Cancer stage C were included in this study. One patient withdrew from the apatinib 250mg group and another patient was added. No DLT occurred in the apatinib 250mg group. Five patients were included in the apatinib 500mg group, and 2 cases of DLT (grade 3 leukopenia) were found among them. Dose escalation was terminated and the MTD was determined to be 250mg. Common AEs of grade 1–2 included fatigue, hypertension, dizziness, bone marrow suppression, and hyperbilirubinemia. The median follow-up time for all patients was 16.0 months. Three patients achieved complete response and another three achieved partial response. The objective response rate was 6/9 (66.7%), and the disease control rate was 9/9 (100%). Three patients relapsed out of the radiation field. The median progression-free survival was 17.0 months, and the median overall survival was 16.7 months.
Conclusions

When combined with IMRT, apatinib 250mg daily was recommended for a phase 2 study of unresectable HCC. The antitumor activity of the combination treatment was encouraging. The safety and efficacy of apatinib combined with IMRT for unresectable HCC should be further investigated in future studies.
Calcium and phosphorus co-doped carbon dots enhance osteogenic differentiation for calvarial defect repair in situ
Authors: Wu Lin , Wu Yunchao , Liu Jingjin , Liu Suwan , Li Qianzhe , Yang Mengyu , Zhang Miaomiao , Ji Qing , Zhang Feimin , Du Fengyi 
Published: July 2021

Abstract
Calvarial bone defect remains a clinical challenge due to the lack of efficient osteo-inductive agent. Herein, a novel calcium and phosphorus codoped carbon dot (Ca/P-CD) for bone regeneration was synthesized using phosphoethanolamine and calcium gluconate as precursors. The resultant Ca/P-CDs exhibited ultra-small size, stable excitation dependent emission spectra and favorable dispersibility in water. Moreover, Ca/P-CDs with good biocompatibility rapidly entered the cytoplasm through endocytosis and increased the expression of bone differentiation genes. After mixing with temperature-sensitive hydrogel, Ca/P-CDs were injected in situ into calvarial defect and promoted the repair of bone injury. These Ca/P-CDs provide a new treatment method for the bone repair and expend the application in the biomedical fields.
Adult Onset Still's Disease With Multiple Lymphadenopathy: a Case Report and Literature Review
Authors: Huang Zhonghua , Xu Hua , Min Qinqin , Li Zhenguo , Bi Jiaxin , Liu Lingyun , Liang Yingying 
Published: July 2021

Abstract
Background: Adult onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder that often presents with systemic multiple lymphadenopathy. In addition to the common paracortical and mixed patterns in AOSD lymph nodes histopathological features, the other morphological patterns include diffuse, necrotic, and follicular patterns. However, there have been very few reports to date on the histopathological description of AOSD lymph nodes.Case presentation: An 18-year-old female presented two months earlier with pain in her large joints with painless rash formation, bilateral posterior cervical lymph nodes, left supraclavicular lymph nodes and left posterior axillary lymph nodes enlargement, and no tenderness. Left cervical lymph node resection was performed for pathological examination. Histologically, lymph node structure is basically preserved, subcapsular sinus, medullary sinus structure exists, there is a lot of histiocytes in the sinus, cortical area is reduced, a few lymphoid follicles of different sizes can be seen, some atrophy, some hyperplasia. The lymphoid tissue in the paracortical region of the lymph node was diffusely proliferative and enlarged, mainly composed of histiocytes with abundant cytoplasm, immunoblasts, and numerous lymphocytes with slightly irregular small to medium-sized nuclei. Nuclear karyorrhexis was easily observed, showing a few nuclear debris and the “starry sky” phenomenon, accompanied by abundant branching high endothelial small vessels with a background of scattered few plasma cells and eosinophil infiltration. Immunohistochemically, lymphoid follicle immunophenotype with reactive proliferative changes. About 40% of the cells in the paracortical region were positive for Ki-67, and the histiocytes expressed CD68, CD163, some expressed S-100, and no MPO. The immunoblasts expressed CD30, CD20, and not ALK or CD15. Background small to medium-sized T cells express CD2, CD3, CD5, CD7, CD4, and CD8, the number of CD8 positive T cells is slightly predominant, and a small number of T cells express GRB and TIA-1. The patient received comprehensive medical treatment after operation, and the condition was stable without progression at the 11-month follow-up evaluation.Conclusion: The presentation of morphologic cases of AOSD lymphadenopathy will increase the awareness of AOSD among pathologists and clinicians, and aid in the diagnosis and differential diagnosis of AOSD lymphadenopathy from other reactive lymphadenopathies and lymphomas.
Selective removal of ZnO nanoparticles from water using 3-aminopropyltriethoxysilane (APTES) and monitoring by meso-tetra(carboxyphenyl)porphyrin (TCPP)
Authors: Zhang Wenyu , Lai Edward P.C. 
Published: July 2021

Abstract
Metal oxide nanoparticles (MONPs) such as TiO2 and ZnO have been engineered for various industrial manufacturing processes with an annual global production exceeding millions of tonnes. Among MONPs, environmental exposure to ZnO nanoparticles may cause a significant toxicity due to bioaccumulation in the human body. Therefore, detection and removal of ZnO nanoparticles in the aqueous environment is highly desired. In this work, 3-aminopropyltriethoxysilane (APTES) was chosen to treat aqueous suspensions containing ZnO and other metal oxide nanoparticles. APTES first formed a thin surface layer on ZnO nanoparticles and continued in branching polymerization to reach out towards other APTES-ZnO nanoparticles. Eventually, a web-like sediment settled down onto the bottom. A high removal efficiency over 99% has attained for ZnO nanoparticles in aqueous suspension. The sedimentation was selective towards ZnO nanoparticles, due to the amino group of ATPES preferentially interacting with ZnO to form a sturdy condensation coagulate. Other MONPs (such as Al2O3, CaO, CeO2, CuO and TiO2) did not form any web-like sediment with APTES but could co-precipitate with the ZnO nanoparticles. Meso-tetra(carboxyphenyl)porphyrin (TCPP) could be added as an indicator to co-precipitate with the sediment, with its color changing from red purple to bright green during the formation of APTES-TCPP-ZnO sediment.
Genome-wide identification and expression profiling of Alba gene family members in response to abiotic stress in tomato (Solanum lycopersicum L.)
Authors: Wai Antt Htet , Cho Lae-Hyeon , Waseem Muhammad , Lee Do-jin , Lee Je-Min , Kim Chang-Kil , Chung Mi-Young 
Published: July 2021

Abstract

Alba (Acetylation lowers binding affinity) proteins are an ancient family of nucleic acid-binding proteins that function in gene regulation, RNA metabolism, mRNA translatability, developmental processes, and stress adaptation. Here, we undertook the first comprehensive genome-wide characterization of the Alba gene family in tomato (Solanum lycopersicum L.). We identified eight tomato Alba genes, which were classified into two groups: genes containing a single Alba domain and genes with a generic Alba domain and RGG/RG repeat motifs. Cis-regulatory elements and target sites for miRNAs, which function in plant development and stress responses, were prevalent in SlAlba genes. To explore the structure–function relationships of tomato Alba proteins, we predicted their 3D structures, highlighting their likely interactions with several putative ligands. Confocal microscopy revealed that SlAlba–GFP fusion proteins were localized to the nucleus and cytoplasm, consistent with putative roles in various signaling cascades. Expression profiling revealed the differential expression patterns of most SlAlba genes across diverse organs. SlAlba1 and SlAlba2 were predominantly expressed in flowers, whereas SlAlba5 expression peaked in 1 cm-diameter fruits. The SlAlba genes were differentially expressed (up- or downregulated) in response to different abiotic stresses. Furthermore, all but one of these genes were induced by abscisic acid treatment, pointing to their possible regulatory roles in stress tolerance via an abscisic acid-dependent pathway. Our characterization of SlAlba genes should facilitate the discovery of additional genes associated with organ and fruit development as well as abiotic stress adaptation in tomato.
Comparison of Clinical Characteristics and Outcomes of Hospitalized Patients with Seasonal Coronavirus Infection and COVID-19: A Retrospective Cohort Study
Authors: Rodriguez-Nava Guillermo , Egoryan Goar , Dong Tianyu , Zhang Qishuo , Hyser Elise , Poudel Bidhya , Yanez-Bello Maria Adriana , Trelles-Garcia Daniela Patricia , Chung Chul Won , Pyakuryal Bimatshu , Imani-Ramos Taraz , Trelles-Garcia Valeria Patricia , Stake Jonathan J 
Published: July 2021

Abstract
Background: Unlike SARS-CoV and MERS-C0V, SARS-CoV-2 can become a recurrent seasonal infection; hence, it is essential to compare the clinical spectrum of COVID-19 to the existent endemic coronaviruses. We conducted a retrospective cohort study of hospitalized patients with seasonal coronavirus (sCoV) infection and COVID-19 to compare their clinical characteristics and outcomes. Methods: A total of 190 patients hospitalized with any documented respiratory tract infection and a positive respiratory viral panel for sCoV from January 1, 2011, to March 31, 2020, were included. Those patients were compared with 190 hospitalized adult patients with molecularly confirmed symptomatic COVID-19 admitted from March 1, 2020, to May 25, 2020. Results: Among 190 patients with sCoV infection, the Human Coronavirus-OC93 was the most common coronavirus with 47.4% of the cases. When comparing demographics and baseline characteristics, both groups were of similar age (sCoV: 74 years vs. COVID-19: 69 years) and presented similar proportions of two or more comorbidities (sCoV: 85.8% vs. COVID-19: 81.6%). More patients with COVID-19 presented with severe disease (78.4% vs. 67.9%), sepsis (36.3% vs. 20.5%), and developed ARDS (15.8% vs. 2.6%) compared to patients with sCoV infection. Patients with COVID-19 had an almost 4-fold increased risk of in-hospital death than patients with sCoV infection (OR 3.86, CI1.99 – 7.49; p <.001). Conclusion: Hospitalized patients with COVID-19 had similar demographics and baseline characteristics to hospitalized patients with sCoV infection; however, patients with COVID-19 presented with higher disease severity, had a higher case fatality rate, and increased risk of death than patients with sCoV.
PENGARUH JUMLAH KUNJUNGAN WISATAWAN, PENERIMAAN PAJAK HOTEL, PAJAK RESTORAN TERHADAP PAD KABUPATEN SIKKA
Authors: Rieshe Rieshe , Aji Andri Waskita 
Published: July 2021

ABSTRACT The purpose of this research is to find out how much influence: (1) the number of tourist visits to the Sikka Regency's original income; (2) hotel tax revenue from the Sikka Regency's original regional income; and (3) restaurant tax receipts from Sikka Regency's original revenue to Sikka Regency's original revenue both partially and simultaneously at the Sikka Regional Financial Management and Asset Management Service (DPPKAD). The data analysis technique used in this study is multiple linear regression analysis. The F test, t test and R² test are processed using SPSS version 16.0. The results of data analysis with a significance of 0.05 indicate that the variable number of tourist visits and hotel tax revenue variables do not affect the original income of Sikka Regency 2016-2018. While the restaurant tax has a positive and significant effect on the original income of Sikka district 2016-2018. The results of the study simultaneously showed that the number of tourist visits, hotel tax receipts and restaurant tax receipts had a positive and significant effect on the genuine income of Sikka Regency. Independent and Dependent Variables affect 36% while 64% are explained independently by variables outside this research model.Keywords: tourist visits, hotel tax, and restaurant tax, first income of region ABSTRAK Tujuan penelitian ini adalah untuk mengetahui seberapa besar pengaruh: (1) jumlah kunjungan wisatawan terhadap pendapatan asli daerah Kabupaten Sikka; (2) penerimaan pajak hotel dari pendapatan asli daerah Kabupaten Sikka; dan (3) Penerimaan Pajak Restoran dari Pendapatan Asli Daerah Kabupaten Sikka terhadap Pendapatan Asli Daerah Kabupaten Sikka baik secara parsial maupun simultan di Dinas Pengelolaan Keuangan dan Aset Daerah (DPPKAD) Sikka. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier berganda. Uji F, uji t dan uji R² diolah dengan menggunakan SPSS versi 16.0. Hasil analisis data dengan signifikansi 0,05 menunjukkan bahwa variabel jumlah kunjungan wisatawan dan variabel penerimaan pajak hotel tidak berpengaruh terhadap pendapatan asli daerah Kabupaten Sikka tahun 2016-2018. Sedangkan, pajak restoran berpengaruh positif dan signifikan terhadap pendapatan asli daerah kabupaten Sikka tahun 2016-2018. Hasil penelitian secara simultan menunjukkan bahwa jumlah kunjungan wisatawan, penerimaan pajak hotel dan penerimaan pajak restoran berpengaruh positif dan signifikan terhadap pendapatan asli Kabupaten Sikka. Variabel independen dan dependen mempengaruhi 36% sedangkan 64% dijelaskan secara independen oleh variabel di luar model penelitian ini.Kata kunci: kunjungan wisatawan, pajak hotel, dan pajak restoran, pendapatan pertama daerah
Effect of magnetic iron-zirconium modified zeolite on the different phosphorus forms in river sediment under aerobic and anoxic conditions
Authors: Wang Chunlei , Gui Herong , Li Chen , Chen Jiayu , Chen Chen 
Published: July 2021

Abstract
In this study, a magnetic iron-zirconium modified zeolite (FeZrMZ) was synthesized. Through sediment culture experiments, the influence of the addition of modified materials on the migration and transformation of phosphorus in river sediments was investigated. The results showed that the modified zeolite could not only effectively reduce the phosphorus concentration in the overlying water, but also significantly reduce the phosphorus concentration in the pore water of sediments. The addition of modified zeolite makes the unstable weakly adsorbed phosphorus (NH4Cl-P) and redox phosphorus (BD-P) transform into the more stable metal oxide-bound phosphorus (NaOH-P) and very stable residual phosphorus (Res-P). The four types of bioavailable phosphorus (BAP), including water-soluble phosphorus (WSP), readily desorbable phosphorus (RDP), algae-available phosphorus (AAP), and NaHCO3 extractable phosphorus (Olsen-P). Under anoxic conditions, they were reduced by 53.5%, 14.1%, 23.8%, and 49.9% respectively. Under aerobic conditions, they were reduced by 23.2%, 16.6%, 32.1%, and 50.0%. The addition of magnetic iron-zirconium modified zeolite could clearly reduce the release potential of phosphorus in sediment, and it could be recovered through the action of an external magnetic field, so it could be used as an effective sediment modifier to control the sediment release of phosphorus.