bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymeric Nanoparticles for Transdermal Delivery of Polyphenols
Authors: Singh Somnath , Vittala Murthy Namratha Turuvekere , Paul Sagar Kumar , Chauhan Harsh 
Published: July 2021

Abstract:
Polyphenols comprise a large group of naturally occurring plant secondary metabolites
with various nutritional and health benefits. They are safe and are found abundantly in the diet. Current
research on polyphenols focuses on their mechanism and their benefits on human health. However,
due to their low solubility and bioavailability, delivery from the conventional route has been
a challenge and their translation into clinical applications has been limited. Topical and transdermal
delivery of polymeric nanoparticles will act as a novel therapeutic approach for promising delivery
of polyphenols. In this review, we have evaluated the existing scientific literature and summarized
the potential use of polymeric nanoparticles as a carrier for polyphenolic compounds for
delivery via topical and transdermal routes for the treatment of skin cancers such as melanoma.
Simvastatin Nanoparticles Loaded Polymeric Film as a Potential Strategy
for Diabetic Wound Healing: In Vitro and In Vivo Evaluation
Authors: Siddique Muhammad Irfan , Tufail Saima , Sarfraz Muhammad , Sohail Muhammad Farhan , Shahid Muhammad Nabeel , Omer Muhammad Ovais , Katas Haliza , Rasool Fatima 
Published: July 2021

Introduction:
The pleiotropic effects of statins are recently explored for wound healing
through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic
wounds.

Aim:
The aim of the present study is to fabricate nanofilm embedded with simvastatin-loaded chitosan
nanoparticles (CS-SIM-NPs) and to explore the efficacy of SIM in diabetic wound healing.

Methods:
The NPs, prepared via ionic gelation, were 173 nm ± 2.645 in size with a zeta potential
of -0.299 ± 0.009 and PDI 0.051 ± 0.088 with excellent encapsulation efficiency (99.97%). The optimized
formulation (CS: TPP, 1:1) that exhibited the highest drug release (91.64%) was incorporated
into the polymeric nanofilm (HPMC, Sodium alginate, PVA), followed by in vitro characterization.
The optimized nanofilm was applied to the wound created on the back of diabetes-induced
(with alloxan injection 120 mg/kg) albino rats.

Results:
The results showed a significant (p < 0.05) improvement in the wound healing process
compared to the diabetes-induced non-treated group. The results highlighted the importance of
nanofilms loaded with SIM-NPs in diabetic wound healing through angiogenesis promotion at the
wound site.

Conclusion:
Thus, CS-SIM-NPs loaded polymeric nanofilms could be an emerging diabetic
wound healing agent in the industry of nanomedicines.
A Review of Recent Advances in Nanomaterial-based Stem Cell Therapy and the Corresponding Risks
Authors: Tian Hao , Yuan Long , Song Yong , Deng Jun , Qi Xiao Wei 
Published: July 2021

:
Stem cell therapy is widely regarded as a promising strategy in regenerative medicine, yet the therapeutic effects of stem cells in vivo are limited by many factors when applied without additional factors, such as poor cell engraftment, uncontrolled differentiation, and unclear cell fates and niches. The emergence of nanotechnology has provided several solutions for these problems. Nanomaterial-based cell labeling and tracking have been extensively investigated in recent decades, and many innovative and multifunctional nanomaterials have been used to reveal the fate of stem cells, allowing more efficient, sensitive, and accurate imaging/tracking strategies for stem cells to be achieved. Nanomaterials enhance stem cell therapy by incorporating or integrating with stem cells and, as scaffolds or substrates, nanomaterials with antioxidant properties that can be used as graft coatings show great promise for clinical transformation. However, current reviews on the subject tend to focus on the various effects of nanomaterials on stem cells and are less concerned with their application to stem cell therapy. Accordingly, we herein present a review of progress in the application of nanomaterials in stem cell therapy over the last three years, which we hope will be of benefit to a comprehensive understanding of nanomaterial-mediated stem cell therapy from lab to pre-clinical practice.
Conceptualizations of Cyberchondria and Relations to the Anxiety Spectrum: Systematic Review and Meta-analysis
Authors: Schenkel Sandra K , Jungmann Stefanie M , Gropalis Maria , Witthöft Michael 
Published: July 2021

Background
Cyberchondria describes the detrimental effects of health-related internet use. Current conceptualizations agree that cyberchondria is associated with anxiety-related pathologies and may best be conceptualized as a safety behavior; however, little is known about its exact underlying mechanisms.

Objective
This systematic review and meta-analysis aims to give an overview of the conceptualizations of cyberchondria and its relation to anxiety-related pathologies, quantify the strength of association to health anxiety by using meta-analyses, highlight gaps in the literature, and outline a hypothetical integrative cognitive-behavioral model of cyberchondria based on the available empirical evidence.

Methods
A systematic literature search was conducted using PubMed, Web of Science, and PsycINFO electronic databases. A total of 25 studies were included for qualitative synthesis and 7 studies, comprising 3069 individuals, were included for quantitative synthesis. The meta-analysis revealed a strong association of cyberchondria (r=0.63) and its subfacets (r=0.24-0.66) with health anxiety.

Results
The results indicate that cyberchondria is a distinct construct related to health anxiety, obsessive-compulsive symptoms, intolerance of uncertainty, and anxiety sensitivity. Further studies should distinguish between state and trait markers of anxiety-related pathologies and use experimental and naturalistic longitudinal designs to differentiate among risk factors, triggers, and consequences related to cyberchondria.

Conclusions
Health-related internet use in the context of health anxiety is best conceptualized as health-related safety behavior maintained through intermittent reinforcement. Here, we present a corresponding integrative cognitive-behavioral model.
Kampung Tangguh: Wujud Kolaborasi antar-Stakeholder dalam Merespons Pandemi COVID-19
Authors: Rahmawati Yusrin , Anugrah Farah Fadillah , Hati Erva Mutiara , Roziqin Ali 
Published: July 2021

Kolaborasi dalam penanganan pandemi COVID-19 sangat dibutuhkan, terutama dalam menangani permasalahan-permasalahan yang muncul. Penelitian ini mencoba untuk menemukan bentuk kolaborasi antar aktor dalam Program Kampung Tangguh. Selain itu, penelitian ini bertujuan untuk mengelaborasiakan peran antar stakeholder dalam merespons pandemi COVID-19, melihat konteks Program Kampung Tangguh Semeru. Menggunakan teori kebencanaan dan konsep terkait desa, penelitian ini berargumen bahwa kunci kesuksesan berjalannya Program Kampung Tangguh Semeru di Jawa Timur merupakan hasil partisipasi dari bawah (bottom up participation) atau bentuk partisipasi masyarakat dan pemerintah dalam menghadapi pandemi COVID-19. Dalam penulisan artikel, peneliti menggunakan pendekatan analisis deskriptif, yang didasarkan pada studi pustaka atau bersumber dari data sekunder.
Kata Kunci: Pandemi, Kolaborasi, Kampung Tangguh

Collaboration in handling COVID-19 pandemic is urgently needed, especially in handling problems that arise from it. This research is try to find collaboration between stakeholders within Tough Village Program (Program Kampung Tangguh). In addition, this study aims to elaborate on the roles between stakeholders in responding to the COVID-19 pandemic. Using disaster theory and concept about village, this research argues that the key to the success of the Tangguh Semeru Village Program in East Java is through bottom up participation or a form of community participation in the government in facing the COVID-19 pandemic. In writing this article using a descriptive analysis approach, which is based on literature study or sourced from secondary data.
Keywords: Pandemic, Collaboration, Tough Village
Assessment of the energy efficiency of a window system with a shading device of the egg-crate type
Authors: Tran Chan Ngoc , Phuong Nguyen Thi Khanh , Gorbarenko Ekaterina V. 
Published: July 2021

Introduction. The article proposes a new energy efficiency assessment method based on a new technique used to calculate the window heat gain. The proposed method takes account of the coefficient of irradiance reduction by the sun shading device. The study was carried out for the shading device of the egg-crate type.
Materials and methods. Calculations are based on the projection of a sunbeam performed for a fraction of a window area in the shade. They take account of the coefficient of irradiance reduction applied due to the presence of the sun shading device. A shading device reduces the irradiance, caused by diffused solar radiation, and coefficient Kbt is applied to demonstrate this process. This coefficient was identified in an experiment and expressed in the form of regression equations.
To evaluate the energy efficiency with regard for the effectiveness of shading devices, coefficient of solar radiation gain reduction β was developed. This coefficient is described by the ratio of the value of solar radiation incoming through a glazed window in the presence of shading device QK to the value of solar radiation incoming through a glazed window that has no shading QKo. The software programme was used to verify the calculations of the heat gain from the solar radiation incoming through the window system with regard for the shading device in various geographical regions in summer (in Hanoi and Moscow).
Results. The results, obtained using the proposed methodology and the observation data, show an insignificant difference in the relative value of β; and they demonstrate a major error when qwindow, or the absolute value of heat entering the room, is taken account of. The heat load, incoming through the window system, is down by 42–45 % in Moscow and by 45–53 % in Hanoi in the hottest period of the year if shading devices are used.
Conclusions. The proposed methodology and computer software, used for a quick assessment of the energy efficiency of a window system equipped with shading devices, allow to design building envelopes that feature high energy efficiency in terms of air conditioning systems, given that coefficient of radiation gain reduction β is taken account of.
Formulation and Evaluation of Self Nano Emulsifying Drug Delivery System of Raloxifene Hydrochloride
Authors: Gayathri T. , Venkata Ramana M. , Rama Rao N. 
Published: July 2021

Raloxifene hydrochloride (RLX) is a selective Estrogen-receptor modulator used to treat osteoporosis as well as breast and endometrial cancer prevention. The bioavailability of RLX is only 2% due to substantial pre-systemic clearance. The goal of this research was to customise and characterise RLX-loaded self-nanoemulsifying drug-delivery systems (SNEDDS) by using bioactive excipients that impact drug metabolism. The droplet size, zeta potential and drug content determination of optimized formulation (F-06) was found to be 147.5 nm, -28.8, 99.67% respectively. The drug release study from the nano formulation was studied in Phosphate buffer 6.8 for all the formulations F1,F2,F3,F4,F5,F6 and F7. The optimized formulation was found to be F6
Keywords: Raloxifene hydrochloride, nanoemulsion, SNEDDS
Physicochemical, ADMET and Druggable properties of Myricetin: A Key Flavonoid in Syzygium cumini that regulates metabolic inflammations
Authors: Soorya C. , Balamurugan S. , Ramya S. , Neethirajan K. , Kandeepan C. , Jayakumararaj R. 
Published: July 2021

Syzygium cumini (Myrtaceae) is a potential medicinal plant traditionally used in indigenous systems of medicines practiced in India and elsewhere due to its functional properties against metabolic inflammations viz., anti-hyperglycemic, anti-inflammatory, cardio-protective, and antioxidant activities. Targeting metabolic inflammation has emerged as a standalone strategy to attenuate metabolic disease. Myricetin (3,5,7,3′,4′,5′-hexahydroxyflavone) is one of the flavonoids from stem bark, leaf, flowers, fruits, pulp and seeds of S. cumini. Therefore, attention has been paid to explore bioactive potentials of this compound in S. cumini owing to its exemplary therapeutic prospective and health-promoting effects. Antioxidant effect of Myricetin from S. cumini has been though experimentally demonstrated, therapeutic potential of Myricetin has not been fully explored. In the present study, physicochemical, ADMET and druggability properties of Myricetin - a key flavonoid compound in S. cumini have been evaluated. Data implicates that this molecule of GRAS standard can be a novel jumble-sale lead in drug discovery.
Keywords: Plant Based Natural Products (PBNPs); Drug Discovery; Pharmacological Activity; ADMET Properties; Flavonoid; Myricetin; Syzygium cumini
New Smartphone Based Colorimetric Method Development and Validation of Emtricitabine in Bulk and Tablet Dosage Form
Authors: Mane Yashashree , Mashru Rajashree 
Published: July 2021

The novel smartphone based colorimetric application called PhotoMetrix-PRO has been used for quantitative analysis of Emtricitabine in bulk and tablet dosage form and it compared with conventional UV –visible spectrophtotometry. Smartphone based colorimetric method and UV method was based on detection of intensity of color with increasing concentration Ammonium metavanadate (inorganic oxidizing agent) which was used for preparation Mandeline reagent they used as coloring agent for colour development .The reagent is orange red colour but when it react with Emtricitabine it convert into green color complex. The developed methods have good linearity 50-250μg/ml. The color intensity of API increase with increasing concentration. All images were captured through mobile phone and analysed in PhotoMetrix PRO application. This application convert image into Red, Green and Blue(RGB)histogram and regression models were built into PhotoMetrix-PRO Application both the method have correlation coefficient R2>0.995.The LOD and LOQ for PhotoMetrix PRO 4.77μg/ml and14.92μg/ml and UV-visible spectrophotometry method 4.99 μg/ml and 14.96 μg/ml respectively. The % RSD of Emtricitabine by PhotoMetrix PRO and UV method was 99% (%RSD <2). Appling statistical tool i.e paired two test on both the methods result indicate that both methods are equally significant.
Keywords: Smartphone, PhotoMetrix PRO, UV Spectrophotometry, RGB
A Study on the Wound Healing Properties of Medicago sativa
Authors: Sharma Prashant , Das Sujit , Mohanta Tanmay 
Published: July 2021

There are lots of herbal plants are using for various treatment, food remedy etc from the prehistoric time. India has taken a great part to garage lots of herbal plants. 3-12 years lifespan containing and cool climate growing Medicago sativa is one of them good rank holder herbal plant. After studying the chemical constituents of M. sativa, it contains vitamin C, vitamin K, genistein which have great wound healing activity as well as it can cure kidney pain, cough, sore muscle, asthma etc. But it cannot take those people who are suffering breast cancer, ovarian cancer etc. At last, after overall study, Medicago sativa has great reflection on human and animals.
Keywords: Medicago sativa, wound healing, vitamin C, vitamin K, genistein, food remedy.
Immunostimulant Effect of Seaweeds in Channa punctatus Challenged by Aeromonas hydrophila
Authors: Muthu Krishnan S , Raja P 
Published: July 2021

The current study focused on to evaluate the bioactive potential and immunostimulant effect of seaweeds in striped murrel Channa punctatus against the fish pathogen Aeromonas hydrophila. The aqueous extracts of seaweeds, Glacilaria foliifera, Acanthophora spicifera and Ulva lactuca were obtained in four different concentrations (25 µL, 50 µL, 75 µL and 100 µL) and evaluated for their immunostimulant potential. Aqueous extract of G. foliifera and A. spicifera has shown promising activity against fish pathogen. G. foliifera exhibited higher bacterial inhibitory zone of 8mm at 100 µL concentration followed by A. spicifera with 6mm at same concentration. The disease challenge study was used to ascertain the immunostimulant efficacy of active seaweed extracts. C. punctatus was administrated with the A. hydrophila and then fed with artificial feed incorporated with seaweeds extract. The survival rate seems to be higher in G. foliifera (80%) when compared with A. spicifera (60%). Observed result shows that both seaweeds possess active metabolites which may pave the way for the discovery of novel compounds with immunostimulant potential, which can be used in the field of aqua industry to augment disease management.
Keywords: Seaweed, Bioactive compounds, Aeromonas hydrophila, Gracilaria polifera
O PROCESSO DE APRENDIZAGEM DOCENTE NO ESTÁGIO E NAS PRÁTICAS COMO COMPONENTE CURRICULAR NO CONTEXTO DE UM IF
Authors: Paniago Rosenilde Nogueira , Oliveira Paulo Silva , Nunes Patrícia Gouvêa , Marcionilio Suzana Maria Loures 
Published: July 2021

No presente texto, serão apresentados os resultados de uma pesquisa, cujo objetivo foi investigar o aprender a ser professor no processo de Estágio Curricular Supervisionado (ECS) e nas Práticas como Componentes Curriculares (PCC) e verificar se há articulação entre estes dois momentos formativos no curso de Licenciatura em Ciências Biológicas de um Instituto Federal de Educação, Ciência e Tecnologia. Adotou-se como metodologia a coleta e análise de narrativas orais de 10 (dez) estagiários e documentos (matriz e ementas) do curso de licenciatura em Ciências Biológicas. Os resultados sinalizam ausência de articulação entre as PCC e o campo de trabalho dos futuros professores e entre o ECS. Apesar de o ECS ter sido apontado como espaço de múltiplas aprendizagens docentes, não se constatou nas narrativas evidências de práticas nas PCC que possibilitassem uma articulação entre estes dois momentos formativos. A falta de aproximação do Licenciando com o ambiente escolar desde o início do curso pode ser um dos fatores que fragilizam o processo de formação docente nas PCC e, por conseguinte, nas práticas do ECS.
MERS-CoV in sheep, goats, and cattle, United Arab Emirates, 2019: Virological and serological investigations reveal an accidental spillover from dromedaries
Authors: Weidinger Pia , Kolodziejek Jolanta , Camp Jeremy , loney tom , Ahmed Dafalla , Ramaswamy Sathishkumar , Tayoun Ahmad Abou , Corman Victor Max , Nowotny Norbert 
Published: July 2021

The recent COVID-19 pandemic has demonstrated again the global threat
posed by emerging zoonotic coronaviruses. During the past two decades
alone, humans have experienced the emergence of several coronaviruses,
such as SARS-CoV in 2003, MERS-CoV in 2012, and SARS-CoV-2 in 2019. To
date, MERS-CoV has been detected in 27 countries, with a case fatality
ratio of approximately 34.5 %. Similar to other coronaviruses, MERS-CoV
presumably originated from bats; however, the main reservoir and primary
source of human infections are dromedary camels. Other species within
the Camelidae family, such as Bactrian camels, alpacas, and
llamas, seem to be susceptible to the infection as well, although to a
lesser extent. In contrast, susceptibility studies on sheep, goats,
cattle, pigs, chickens, and horses obtained divergent results. In the
present study, we tested nasal swabs and/or sera from 55 sheep, 45
goats, and 52 cattle, collected at the largest livestock market in the
United Arab Emirates, where dromedaries are also traded, for the
presence of MERS-CoV nucleic acid by RT-qPCR, and for specific
antibodies by immunofluorescence assay (IFA). All sera were negative for
MERS-CoV-reactive antibodies, but the nasal swab of one sheep (1.8 %)
was positive for MERS-CoV nucleic acid. Next generation sequencing (NGS)
of the complete N gene of the sheep-derived MERS-CoV revealed
>99 % nucleotide identity to MERS-CoV sequences of five
dromedaries in nearby pens and to three reference sequences. The NGS
sequence of the sheep-derived MERS-CoV was confirmed by conventional
RT-PCR of a part of the N gene and subsequent Sanger sequencing.
All MERS-CoV sequences clustered within clade B, lineage 5. In
conclusion, our study shows that non-camelid livestock, such as sheep,
goats, and cattle do not play a major role in MERS-CoV epidemiology. The
one sheep that tested positive most likely reflects an accidental viral
spillover event from infected dromedaries in nearby pens.
Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis
Authors: Loxton Phoebe , Narayan Kruthika , Munns Craig F. , Craig Maria E. 
Published: July 2021

BACKGROUND
There is substantial evidence that adults with type 1 diabetes have reduced bone mineral density (BMD); however, findings in youth are inconsistent.

PURPOSE
To perform a systematic review and meta-analysis of BMD in youth with type 1 diabetes using multiple modalities: DXA, peripheral quantitative computed tomography (pQCT), and/or quantitative ultrasound (QUS).

DATA SOURCES
PubMed, Embase, Scopus, and Web of Science from 1 January 1990 to 31 December 2020, limited to humans, without language restriction.

STUDY SELECTION
Inclusion criteria were as follows: cross-sectional or cohort studies that included BMD measured by DXA, pQCT, or QUS in youth (aged &lt;20 years) with type 1 diabetes and matched control subjects.

DATA EXTRACTION
We collected data for total body, lumbar spine, and femoral BMD (DXA); tibia, radius, and lumbar spine (pQCT); and phalanx and calcaneum (QUS). Weighted mean difference (WMD) or standardized mean difference was estimated and meta-regression was performed with age, diabetes duration, and HbA1c as covariates.

DATA SYNTHESIS
We identified 1,300 nonduplicate studies; 46 met the inclusion criteria, including 2,617 case and 3,851 control subjects. Mean ± SD age was 12.6 ± 2.3 years. Youth with type 1 diabetes had lower BMD: total body (WMD −0.04 g/cm2, 95% CI −0.06 to −0.02; P = 0.0006), lumbar spine (−0.02 g/cm2, −0.03 to −0.0; P = 0.01), femur (−0.04 g/cm2, −0.05 to −0.03; P &lt; 0.00001), tibial trabecular (−11.32 g/cm3, −17.33 to −5.30; P = 0.0002), radial trabecular (−0.91 g/cm3, −1.55 to −0.27; P = 0.005); phalangeal (−0.32 g/cm3, −0.38 to −0.25; P &lt; 0.00001), and calcaneal (standardized mean difference −0.69 g/cm3, −1.11 to −0.26; P = 0.001). With use of meta-regression, total body BMD was associated with older age (coefficient −0.0063, −0.0095 to −0.0031; P = 0.002) but not with longer diabetes duration or HbA1c.

LIMITATIONS
Meta-analysis was limited by the small number of studies with use of QUS and pQCT and by lack of use of BMD z scores in all studies.

CONCLUSIONS
Bone development is abnormal in youth with type 1 diabetes, assessed by multiple modalities. Routine assessment of BMD should be considered in all youth with type 1 diabetes.
Uprawa roślin cytrusowych w Europie w świetle dawnych traktatów ogrodniczych
Authors: Malawski Seweryn Mikołaj , Kot Natalia , Szefler Sylwia 
Published: July 2021

Artykuł ma formę pracy przeglądowej, której celem jest zaprezentowanie historii i dawnych technik uprawy roślin z rodzaju Citrus L. w Europie, w tym w Polsce. Metodyka badawcza polegała na analizie materiałów archiwalnych, obejmujących historyczne traktaty z zakresu ogrodnictwa i rolnictwa. Należą do nich rozprawy powstałe na przestrzeni XVI-XVIII w. m.in. autorstwa: G. B. Ferrariego, J. Commelina, J. van der Groena, J. Ch. Volkamera, J. S. Elsholtza, oraz W. Sierakowskiego, A. P. Jabłonowskiej czy J. K. Kluka. Opisano nowożytne dzieje hodowli roślin cytrusowych w Europie oraz przedstawione w traktatach metody, obejmujące uprawę w gruncie oraz w pojemnikach i sposoby zimowania. Scharakteryzowano także rodzaje wznoszonych w tym celu drewnianych i murowanych oranżerii oraz wykorzystywanych donic.