bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Caputo–Hadamard type coupled systems of nonconvex fractional differential inclusions
Authors: Belmor Samiha , Jarad Fahd , Abdeljawad Thabet 
Published: August 2021

AbstractThis research article is mainly concerned with the existence of solutions for a coupled Caputo–Hadamard of nonconvex fractional differential inclusions equipped with boundary conditions. We derive our main result by applying Mizoguchi–Takahashi’s fixed point theorem with the help of$\mathcal{P}$P-function characterizations.
Bog ecosystems as a playground for plant–microbe coevolution: bryophytes and vascular plants harbour functionally adapted bacteria
Authors: Wicaksono Wisnu Adi , Cernava Tomislav , Berg Christian , Berg Gabriele 
Published: August 2021

Abstract
Background
Bogs are unique ecosystems inhabited by distinctive, coevolved assemblages of organisms, which play a global role for carbon storage, climate stability, water quality and biodiversity. To understand ecology and plant–microbe co-occurrence in bogs, we selected 12 representative species of bryophytes and vascular plants and subjected them to a shotgun metagenomic sequencing approach. We explored specific plant–microbe associations as well as functional implications of the respective communities on their host plants and the bog ecosystem.

Results
Microbial communities were shown to be functionally adapted to their plant hosts; a higher colonization specificity was found for vascular plants. Bryophytes that commonly constitute the predominant Sphagnum layer in bogs were characterized by a higher bacterial richness and diversity. Each plant group showed an enrichment of distinct phylogenetic and functional bacterial lineages. Detailed analyses of the metabolic potential of 28 metagenome-assembled genomes (MAGs) supported the observed functional specification of prevalent bacteria. We found that novel lineages of Betaproteobacteria and Actinobacteria in the bog environment harboured genes required for carbon fixation via RuBisCo. Interestingly, several of the highly abundant bacteria in both plant types harboured pathogenicity potential and carried similar virulence factors as found with corresponding human pathogens.

Conclusions
The unexpectedly high specificity of the plant microbiota reflects intimate plant–microbe interactions and coevolution in bog environments. We assume that the detected pathogenicity factors might be involved in coevolution processes, but the finding also reinforces the role of the natural plant microbiota as a potential reservoir for human pathogens. Overall, the study demonstrates how plant–microbe assemblages can ensure stability, functioning and ecosystem health in bogs. It also highlights the role of bog ecosystems as a playground for plant–microbe coevolution.
Alteration in expression level of some growth and stress-related genes after rhizobacteria inoculation to alleviate drought tolerance in sensitive rice genotype
Authors: Omar Samar A. , Fetyan Nashwa A. H. , Eldenary Medhat E. , Abdelfattah Mohamed H. , Abd-Elhalim Haytham M. , Wrobel Jacek , Kalaji Hazem M. 
Published: August 2021

Abstract
Background
Drought stress is one of the major abiotic stresses that adversely affect rice production. Four rice genotypes, Giza177, IR64 (as sensitive genotypes) and Vandana, Orabi3 (as tolerant genotypes) were used to screen and characterize the soil microbes associated with each genotype under drought stress.

Results
The soil microbes associated with the tolerant genotypes showed high drought tolerance and high levels of enzyme activity. The most drought-tolerant isolates were inoculated with the sensitive genotype Giza177 under drought conditions. Some morphological, biochemical and molecular responses of inoculated plants were estimated. Inoculated plants showed regulation of some growth and stress-related genes (COX1, AP2-EREBP, GRAM, NRAMP6, NAM, GST, DHN and three genes of expansin (EXP1, EXP2 and EXP3) under drought conditions. Expression profiling of these genes were highly induced in plants inoculated with 4E11 and were correlated with improved growth status under drought stress.

Conclusion
Based on this, drought-tolerant plant growth-promoting rhizobacteria (PGPRs) were associated with the drought-tolerant genotype (Orabi 3). They were related to the significant increase in soil enzymes activities (dehydrogenase, nitrogenase, urease and alkaline phosphatase) in the rhizosphere of tolerant genotype. Inoculation the drought-sensitive genotype (Giza 177) with the most drought-tolerant isolates improved the tolerance status of the sensitive rice genotype and induced the expression of some growth and stress-responsive genes. AP2-EREBP, NRAMP6, DHN and all expansin genes (EXP1, EXP2 and EXP3) were the highly induced genes in inoculated plants with 4E11 strain and the consortium of three selected strains under drought condition.

Graphic abstract
Diabetes, hypertension and dyslipidemia medication prescribing in Qatari primary care settings: a retrospective analysis of electronic medical records
Authors: Syed Mohamed Ahmed , Al Nuaimi Ahmed Sameer , A/Qotba Hamda Abdulla , Zainel Abduljaleel Abdullatif , Marji Tamara , Razaq Uzma 
Published: August 2021

Abstract
Background
Globally, non-communicable diseases (NCDs) are recognised as a leading cause of morbidity and mortality. Medications and medicines optimisation play an important role in the management of modifiable physiological risk factors and NCDs. The importance of lifestyle interventions in prevention of modifiable risk factors is also well established. The aim of this paper was to describe the quantity of type 2 diabetes mellitus (T2DM), hypertension and dyslipidaemia prescribing in Qatari primary care settings. Its findings will provide necessary information to inform pharmaceutical policy and practice.

Methods
The study was undertaken in Qatar’s publicly funded primary health care centres. Data sources for this study comprised electronic medical records. The Anatomical Therapeutic Chemical (ATC) drug classification system was used to classify the medications prescribed. The number and proportion of medications by age, sex, nationality and diagnosis (T2DM, hypertension and dyslipidaemia) were reported.

Results
A total 81,569 individuals were included (18–29 years 2.4%; 30–39 years 11.7%; 40–49 years 25.4%; 50–59 years 31.9% and ≥ 60 years 28.6%). 55.6% participants were male. On average 10.2 medications were prescribed per person and 2.3 medications were included in each prescription. T2DM medications were most prescribed (N = 361,87780,799; 43.2%) followed by hypertension (N = 303,086; 36.2%) and dyslipidaemia (N = 172,163; 20.5%). Of the total medications prescribed, 72% (N = 605,488) were prescribed in individuals aged 50 years and above. Men were prescribed 62% (N = 515,043) medications while women were prescribed 38% (N = 322,083) medications. Southern Asians (N = 330,338; 39%) were prescribed most medication followed by Qataris (N = 181,328; 22%) and Northern African (N = 145,577; 17%).

Conclusions
In Qatar’s primary care settings, average medications prescribed per patients were found to be higher compared to other populations. While medications were actively prescribed for the 3 conditions, the study found variations by medication type, age, gender and nationality. Rational guidelines for the utilisation of medications need to be established with the support of real-world evidence.
An epidemiologic comparison of acute and overuse injuries in high school sports
Authors: Ritzer Erin E. , Yang Jingzhen , Kistamgari Sandhya , Collins Christy L. , Smith Gary A. 
Published: August 2021

AbstractBackgroundAcute and overuse injuries affect millions of high school athletes annually and a better understanding of differences between these injuries is needed to help guide prevention, treatment, and rehabilitation strategies. This study compares acute and overuse injuries using a nationally representative sample of high school athletes.MethodsInjuries among United States high school athletes participating in 5 boys’ sports (football, soccer, basketball, wrestling, baseball) and 4 girls’ sports (soccer, volleyball, basketball, softball) reported in the High School RIO™ surveillance system during the 2006-07 through 2018-19 school years were classified as acute or overuse. National estimates and injury rates were calculated.ResultsOf 17 434 646 estimated injuries, 92.0 % were acute and 8.0 % were overuse. The acute injury rate was higher than the overuse injury rate among both male (Rate Ratio [RR] 16.38, 95 % CI: 15.70–17.10) and female (RR 8.14, 95 % CI: 7.71–8.60) athletes. The overuse injury rate per 10,000 athlete exposures among female athletes (1.8) was slightly higher than among males (1.4). The rate of acute injury compared with the rate of overuse injury was higher during competition (RR 32.00, 95 % CI: 29.93–34.22) than practice (RR 7.19, 95 % CI: 6.91–7.47). Boys’ football contributed the most acute (42.1 %) and overuse (23.7 %) injuries among the 9 sports. Among female sports, girls’ soccer contributed the most acute (15.6 % of all acute injuries) and overuse (19.4 % of all overuse injuries) injuries. The lower extremity was most commonly injured in acute (48.9 %) and overuse (65.9 %) injuries. Ligament sprain (31.7 %) and concussion (21.0 %) were the most common acute injury diagnoses, while muscle strain (23.3 %) and tendonitis (23.2 %) were the most common overuse injury diagnoses. Compared with acute injuries, overuse injuries were more likely to result in time loss from sports participation of < 1 week among both boys and girls and across most sports. Acute injuries were more likely than overuse injuries to cause a time loss of 1–3 weeks or medical disqualification from sports participation.ConclusionsAcute and overuse injuries display many differences that provide opportunities for data-informed athlete preparation, treatment, and rehabilitation, which may reduce injuries and improve injury outcomes in high school athletics.
Rotation of the Philippine Sea plate inferred from paleomagnetism of oriented cores taken with an ROV-based coring apparatus
Authors: Yamazaki Toshitsugu , Chiyonobu Shun , Ishizuka Osamu , Tajima Fumisato , Uto Naoki , Takagawa Shinichi 
Published: August 2021

AbstractReconstructing the history of Philippine Sea (PHS) plate motion is important for better understanding of the tectonics of the surrounding plates. It is generally considered that the PHS plate migrated northward since Eocene, but its rotation has not been constrained well; some reconstructions incorporated a large clockwise rotation but others did not. This is mainly because the difficulty of collecting oriented rocks from the mostly submerged PHS plate hindered establishing an apparent polar wander path. In this study, we conducted a paleomagnetic study of oriented cores taken using an ROV-based coring apparatus from the Hyuga Seamount on the northern part of the Kyushu-Palau Ridge, a remnant arc in the stable interior of the PHS plate. Stepwise thermal and alternating-field demagnetizations were applied to specimens taken successively from two ~ 30 cm long limestone cores of middle to late Oligocene age, and characteristic remanent magnetization directions could be isolated. Declination and inclination of D = 51.5° and I = 39.8°, respectively, were obtained as the mean of the two cores. The easterly-deflected declination means ~ 50° clockwise rotation of the PHS plate since middle to late Oligocene. In addition, ~ 5° latitudinal change of the site is estimated from the mean inclination. The result implies that the Kyushu-Palau Ridge was located to the southwest of the present position in middle to late Oligocene, and that PHS plate rotation as well as the Shikoku and Parece Vela Basin spreading contributed to the eastward migration of the Izu-Ogasawara (Bonin) Arc to the current position.
Coupled investigations of ionosphere variations over European and Japanese regions: observations, comparative analysis, and validation of models and facilities
Authors: Panasenko Sergii V. , Kotov Dmytro V. , Otsuka Yuichi , Yamamoto Mamoru , Hashiguchi Hiroyuki , Richards Philip G. , Truhlik Vladimir , Bogomaz Oleksandr V. , Shulha Maryna O. , Zhivolup Taras G. , Domnin Igor F. 
Published: August 2021

AbstractThis paper presents the results of a coordinated measurement campaign with ground based and satellite observations over European and Japanese regions during September 5–6, 2017. Two incoherent scatter radars, two satellite missions, International Reference Ionosphere (IRI-2016) empirical model, and Field Line Interhemispheric Plasma (FLIP) physical model were employed to examine the regular behavior of the F2-layer peak height and density and the topside ionosphere electron density, electron, and ion temperatures as well as traveling ionospheric disturbances (TIDs). The daily ionospheric variations over Kharkiv and Shigaraki exhibited similar behavior qualitatively and quantitatively. The results show that none of the empirical IRI-2016 models of F2-layer peak height, topside electron density, and temperature can be preferred for predicting the key qualitative features of variations in ionospheric plasma parameters over Kharkiv and Shigaraki. The likely reason is rapid day to day changes in solar activity and series of moderate enhancements of magnetic activity occurring in the observation period and preceding days. Compared with IRI-2016 model, the FLIP physical model was shown to provide the best agreement with the observations when constrained to follow the observed diurnal variations of F2-layer peak height both over Europe and Japan. This paper presents the first direct comparison of the mid-latitude electron density measured by the Swarm satellite with incoherent scatter radar data and it confirms the high quality of the space-borne data. For the first time, evidence of the possible need to increase the neutral hydrogen density in NRLMSISE-00 model by at least a factor of 2 was obtained for the Asian longitudinal sector. The TIDs, which have predominant periods of about 50 min over Europe and 80 min over Japan, were detected, likely caused by passage of the solar terminator. Such a difference in the periods could indicate regional features and is the topic for further research.
Laparoscopic low anterior resection for rectal cancer wherein the inferior mesenteric artery arose from the superior mesenteric artery: a case report
Authors: Korai Takahiro , Okita Kenji , Nishidate Toshihiko , Okuya Koichi , Akizuki Emi , Sato Yu , Hamabe Atsushi , Kyuno Daisuke , Ishii Masayuki , Miura Ryo , Imamura Masafumi , Nagayama Minoru , Murakami Takeshi , Nobuoka Takayuki , Ito Tatsuya , Takemasa Ichiro 
Published: August 2021

Abstract
Background
Few cases have been reported of colorectal cancer with inferior mesenteric artery (IMA) branching abnormalities; therefore, the lymphatic flow in such cases remains unknown. We report the first case of locally advanced rectal cancer in which the IMA arose from the superior mesenteric artery (SMA) in which we achieved to visualize the lymphatic flow.

Case presentation
A 65-year-old woman complaining of bloody stools was investigated in our hospital and suspected with rectal cancer. Colonoscopy and abdominal enhanced computed tomography (CT) revealed a circumscribed, localized ulcerative tumor in the rectum. 3-Dimensional contrast-enhanced computed tomography (3D-CT) showed that the IMA arose from the SMA. The patient was diagnosed with rectal cancer (cT3N0M0, cStage IIa) and laparoscopic low anterior resection was performed. The sigmoid colon was resected using the medial approach. Only the plexus of the colic branch of the lumbar splanchnic nerve was observed at the site where the root of the IMA usually exists and showed interruption of the indocyanine green (ICG) fluorescence-illuminated lymphatics. The root of the IMA was ligated, and Japanese D3 lymphadenectomy was performed, preserving the accessory middle colic artery. All fluorescent lymph nodes were resected. The pathological diagnosis was pT4aN1aM0 stage IIIb. The patient’s postoperative course was uneventful. Adjuvant chemotherapy was administered, and the patient was recurrence-free at 1.5 years after surgery.

Conclusions
We were able to perform safe and appropriate surgery oncologically, despite abnormal vascular anatomy, due to preoperative identification using 3D-CT and intraoperative navigation using ICG administration.
A feasibility study using mid-upper arm circumference as the sole anthropometric criterion for admission and discharge in the outpatient treatment for severe acute malnutrition
Authors: Garba Souna , Salou Halidou , Nackers Fabienne , Ayouba Amadou , Escruela Montse , Guindo Ousmane , Rocaspana Mercé , Grais Rebecca F. , Isanaka Sheila 
Published: August 2021

Abstract
Background
The World Health Organization recommends the use of a weight-for-height Z-score (WHZ) and/or mid-upper arm circumference (MUAC) as anthropometric criteria for the admission and discharge of young children for the community-based management of severe acute malnutrition. However, using MUAC as a single anthropometric criterion for admission and discharge in therapeutic nutritional programs may offer operational advantages to simplify admission processes at therapeutic nutritional centers and improve program coverage.

Methods
This pragmatic, non-randomized, intervention study compared a standard outpatient nutritional program (n = 824) for the treatment of uncomplicated severe acute malnutrition using WHZ < − 3 and/or MUAC< 115 mm and/or bipedal edema for admission and discharge to a program (n = 1019) using MUAC as the sole anthropometric criterion for admission (MUAC< 120 mm) and discharge (MUAC ≥125 mm at two consecutive visits) in the Tahoua Region of Niger.

Results
Compared to the standard program, the MUAC-only program discharged more children as recovered (70.1% vs. 51.6%; aOR 2.31, 95%CI 1.79–2.98) and fewer children as non-respondent or defaulters, based on respective program definitions. The risk of non-response was high in both programs. Three months post-discharge, children who were discharged after recovery in the MUAC-only program had lower WHZ and MUAC measures. Sixty-three children ineligible for the MUAC-only program but eligible for a standard program (MUAC ≥120 mm and WHZ < -3) were followed for twelve weeks and the anthropometric status of 69.8% of these children did not deteriorate (i.e. MUAC ≥120 mm) despite not immediately receiving treatment in the MUAC-only program.

Conclusions
The results from this study share the first operational experience of using MUAC as sole anthropometric criterion for admission and discharge in Niger and overall support the consideration for MUAC-only programming: the MUAC-only model of care was associated with a higher recovery and a lower defaulter rate than the standard program with very few children found to be excluded from treatment with an admission criterion of MUAC < 120 mm. Further consideration of the appropriate MUAC-based discharge criterion as it relates to an increased risk of non-response and adverse post-discharge outcomes would be prudent.
The long-term transformation of the concept of CSR: towards a more comprehensive emphasis on sustainability
Authors: Aslaksen Hildegunn Mellesmo , Hildebrandt Clare , Johnsen Hans Chr. Garmann 
Published: August 2021

AbstractThis article adds to the discussion of the long-term transformation of CSR, presenting a perspective on the interplay between CSR debate and public discourse on business responsibility. 50 years after Milton Friedman’s provoking claim that the only responsibility for business is to seek profit, a broader debate has emerged aligning CSR with an increasingly comprehensive concept of sustainability. We trace this evolution of the concept during the last three decades focusing on the intersection of economic, social, and environmental responsibility. Based on discourse analysis of news articles and opinion pieces in the largest public newspaper in Norway from 1990 until 2018, the study confirms that discussions on CSR, sustainability and the social model often approach the same challenges. We argue that sustainability has become the dominating term in popular usage for describing the relationship between business and society. Based on our analysis of the public debate, CSR has become amore comprehensive term,transformed from being a term mainly related to internal business affairs to part of a broader societal discussion about sustainability.
The dopamine receptor D4 regulates the proliferation of pulmonary arteries smooth muscle in broilers by downregulating AT1R
Authors: Yang Xiaoqi , Fu Yang , Wu Lianfeng , Li Antong , Ji Luyao , Li Hao , Peng Yuxuan , Zhang Jiabin , Zhou Donghai , Zhou Huiping 
Published: August 2021

AbstractThe major cause of pulmonary vascular remodeling in broilers is abnormal proliferation of vascular smooth muscle cells (VSMCs), and one of the main causes of pulmonary hypertension syndrome (PHS) in broilers is pulmonary artery vascular remodeling. Forty Arbor Acres (AA) broilers were randomly divided into four groups (n = 10): a control group (deionized water, 0 g/L NaCl), a freshwater group (FW, deionized water + 1 g/L NaCl), highly salinized freshwater group 1 (H-SFW-1, deionized water + 2.5 g/L NaCl) and highly salinized freshwater group 2 (H-SFW-2, deionized water + 5 g/L NaCl). The results of in vivo experiments showed that vascular smooth muscle of the broilers could be significantly proliferated by intake of high-salinity fresh water (H-SFW-1 & H-SFW-2), which significantly increased the content of angiotensin II (Ang II) and the expression of angiotensin II type 1 (AT1) receptor protein. Meanwhile, it significantly decreased the expression of dopamine receptor D4 (DRD4) protein. The results of in vitro experiments showed that exogenous Ang II induced the proliferation of primary VSMCs in broilers, which could be significantly inhibited by DRD4 agonists (D4A, HY-101384A) and enhanced by DRD4 inhibitors (D4I, HY-B0965). In addition, the results of immunoblotting and fluorescence quantitative PCR showed that AT1 receptors could be negatively regulated by DRD4 in VSMCs of broilers, either at the transcriptional or translational level. At the same time, the expression of AT1 receptor could be increased by DRD4 inhibition by D4I and decreased by DRD4 activation by D4A. The negative regulatory effect of DRD4 on AT1 receptor occurred in a dose-dependent manner. These results indicate that long-term intake of highly salinized fresh water can cause PHS in broilers, accompanied by varying degrees of proliferation of pulmonary artery smooth muscle. This mechanism may involve response of its receptor being induced by increased Ang II, while DRD4 can negatively regulate it.