bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-lapse monitoring of fertilized human oocytes focused on the incidence of 0PN embryos in conventional in vitro fertilization cycles
Authors: Kobayashi Tatsuya , Ishikawa Hiroshi , Ishii Kumiko , Sato Asuka , Nakamura Natsuko , Saito Yoshiko , Hasegawa Hisataka , Fujita Maki , Mitsuhashi Akira , Shozu Makio 
Published: September 2021

AbstractWe aimed to investigate why the incidence of embryos derived from oocytes with no pronuclei (0PN) decreases using time-lapse monitoring (TLM) versus fixed-point assessment in conventional IVF cycles. We analyzed 514 embryos monitored with TLM 6–9 h after insemination and 144 embryos monitored using microscopic assessment 18–21 h after insemination. The primary endpoint of this study was the incidence of 0PN-derived embryos in short insemination followed by TLM. The secondary endpoint was the duration of insemination. As exploratory endpoints, we analyzed the blastulation rate and cryo-warmed blastocyst transfer outcome of embryos with early PN fading, whereby PN disappeared within < 20 h following the initiation of insemination. The incidence of 0PN-derived embryo reduced more significantly through TLM than through fixed-point observation. The microscopic assessment time was more significantly delayed in the 0PN-derived embryo than that in the 2PN-derived embryo. The embryo with early PN fading formed good-quality blastocysts, and their pregnancy outcomes were similar to those of other embryos. Most 0PN-derived embryos in the fixed-point assessment might have resulted from missed observation of PN appearance in the early-cleaved embryos. TLM or strict laboratory schedule management may reduce 0PN-derived embryos by reducing missed PN observations.
Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations
Authors: Yatagai Yohei , Oshima Hisayuki , Sakamoto Tohru , Shigemasa Rie , Kitazawa Haruna , Hyodo Kentaro , Masuko Hironori , Iijima Hiroaki , Naito Takashi , Saito Takefumi , Hirota Tomomitsu , Tamari Mayumi , Hizawa Nobuyuki 
Published: September 2021

AbstractETS variant transcription factor 4 (ETV4) is a recently identified transcription factor that regulates gene expression-based biomarkers of asthma and IL6 production in an airway epithelial cell line. Given that ETV4 has not yet been implicated in asthma genetics, we performed genetic association studies of adult asthma in the ETV4 region using two independent Japanese cohorts (a total of 1532 controls and 783 cases). SNPs located between ETV4 and mesenchyme homeobox 1 (MEOX1) were significantly associated with adult asthma, including rs4792901 and rs2880540 (P = 5.63E−5 and 2.77E−5, respectively). The CC haplotype of these two SNPs was also significantly associated with adult asthma (P = 8.43E−7). Even when both SNPs were included in a logistic regression model, the association of either rs4792901 or rs2880540 remained significant (P = 0.013 or 0.007, respectively), suggesting that the two SNPs may have independent effects on the development of asthma. Both SNPs were expression quantitative trait loci, and the asthma risk alleles at both SNPs were correlated with increased levels of ETV4 mRNA expression. In addition, the asthma risk allele at rs4792901 was associated with increased serum IL6 levels (P = 0.041) in 651 healthy adults. Our findings imply that ETV4 is involved in the pathogenesis of asthma, possibly through the heightened production of IL6.
Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
Authors: Malave Lauren , Zuelke Dustin R. , Uribe-Cano Santiago , Starikov Lev , Rebholz Heike , Friedman Eitan , Qin Chuan , Li Qin , Bezard Erwan , Kottmann Andreas H. 
Published: September 2021

AbstractL-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement therapy for Parkinson’s Disease. The mechanistic underpinnings of LID remain obscure. Here we report that diminished sonic hedgehog (Shh) signaling in the basal ganglia caused by the degeneration of midbrain dopamine neurons facilitates the formation and expression of LID. We find that the pharmacological activation of Smoothened, a downstream effector of Shh, attenuates LID in the neurotoxic 6-OHDA- and genetic aphakia mouse models of Parkinson’s Disease. Employing conditional genetic loss-of-function approaches, we show that reducing Shh secretion from dopamine neurons or Smoothened activity in cholinergic interneurons promotes LID. Conversely, the selective expression of constitutively active Smoothened in cholinergic interneurons is sufficient to render the sensitized aphakia model of Parkinson’s Disease resistant to LID. Furthermore, acute depletion of Shh from dopamine neurons through prolonged optogenetic stimulation in otherwise intact mice and in the absence of L-Dopa produces LID-like involuntary movements. These findings indicate that augmenting Shh signaling in the L-Dopa treated brain may be a promising therapeutic approach for mitigating the dyskinetic side effects of long-term treatment with L-Dopa.
Isochoric supercooled preservation and revival of human cardiac microtissues
Authors: Powell-Palm Matthew J. , Charwat Verena , Charrez Berenice , Siemons Brian , Healy Kevin E. , Rubinsky Boris 
Published: September 2021

AbstractLow-temperature biopreservation and 3D tissue engineering present two differing routes towards eventual on-demand access to transplantable biologics, but recent advances in both fields present critical new opportunities for crossover between them. In this work, we demonstrate sub-zero centigrade preservation and revival of autonomously beating three-dimensional human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants. We show that these tissues can cease autonomous beating during preservation and resume it after warming, that the supercooling process does not affect sarcomere structural integrity, and that the tissues maintain responsiveness to drug exposure following revival. Our work suggests both that functional three dimensional (3D) engineered tissues may provide an excellent high-content, low-risk testbed to study complex tissue biopreservation in a genetically human context, and that isochoric supercooling may provide a robust method for preserving and reviving engineered tissues themselves.
Tissue-based metabolomics reveals metabolic signatures and major metabolic pathways of gastric cancer with help of transcriptomic data from TCGA
Authors: Wang Yaqin , Chen Wenchao , Li Kun , Wu Gang , Zhang Wei , Ma Peizhi , Feng Siqi 
Published: September 2021

Abstract
Purpose: The aim of the present study was to screen differential metabolites of gastric cancer (GC) and identify the key metabolic pathways of GC.
Methods: GC (n=28) and matched paracancerous (PC) tissues were collected, and LC-MS/MS analysis were performed to detect metabolites of GC and PC tissues. Metabolite pathways based on differential metabolites were enriched by MetaboAnalyst, and genes related to metabolite pathways were identified using the KEGGREST function of the R software package. Transcriptomics data from The Cancer Genome Atlas (TCGA) was analyzed to obtain differentially expressed genes (DEGs) of GC. Overlapping genes were acquired from metabonimics and transcriptomics data. Pathway enrichment analysis was performed using String. The protein expression of genes was validated by the Human Protein Atlas (HPA) database.
Results: A total of 325 key metabolites were identified, 111 of which were differentially expressed between the GC and PC groups. Seven metabolite pathways enriched by MetaboAnalyst were chosen, and 361 genes were identified by KEGGREST. A total of 2831 DEGs were identified from the TCGA cohort. Of these, 1317 were down-regulated, and 1636 were up-regulated. Twenty-two overlapping genes were identified between genes related to metabolism and DEGs. Glycerophospholipid (GPL) metabolism is likely associated with GC, of which AGPAT9 and ETNPPL showed lower expressed in GC tissues.
Conclusions: We investigated the tissue-based metabolomics profile of GC, and several differential metabolites were identified. GPL metabolism may affect on progression of GC.
Time‐iteration‐domain integrated learning control for robust trajectory tracking and disturbance rejection: With application to a PMLSM
Authors: Liu Weike , Xu Yunlang , Ding Runze , Shu Feng , Yang Xiaofeng 
Published: September 2021

AbstractIterative learning control (ILC) has been widely used to improve motion performance when reference trajectories and external disturbances are strictly repetitive. However, the occurrence of non‐repetitive trajectories and disturbances would significantly deteriorate the performance of traditional ILC methods. To solve this problem, a time‐iteration‐domain integrated learning control (TIDLC) scheme is proposed for enhancing robustness against non‐repetitive trajectories and disturbances. The TIDLC scheme consists of an ILC term and a time‐domain compensator (TC) term. While the ILC term that performs learning in the iteration‐domain preserves excellent performance under repetitive tasks, the TC term that is updated in the time‐domain can compensate for the variations of trajectories and disturbances. Stability and performance analyses are discussed in both the time‐domain and iteration‐domain. Experimental results on a permanent magnet linear synchronous motor (PMLSM) positioning system verify the validity of the proposed scheme.
Underwater image enhancement via LBP‐based attention residual network
Authors: Huang ZhiXiong , Li Jinjiang , Hua Zhen 
Published: September 2021

AbstractOwing to the influence of light absorption and scattering in underwater environments, underwater images exhibit color deviation, low contrast and detail blur, and other degradations. This paper proposes an underwater image enhancement method combining a residual convolution network, local binary pattern (LBP), and self‐attention mechanism. The LBP operator processes the input underwater images. The LBP feature images and underwater images thus obtained constitute the network input. The network consists of three modules: a color correction module to remove the color deviation in underwater images, detail repair module to restore the integrity of details, and an LBP auxiliary enhancement module for global enhancement of image details. The correction and repair modules generate the correct color image and detailed supplement images, respectively. The final‐result image is obtained by superpositioning the two generated images. The experimental results confirm that our method can reproduce the bright colors and complete details of the visual effect, showing a significant improvement over other advanced methods in quantitative evaluation.
Switchback-like structures observed by Solar Orbiter
Authors: Fedorov A. , Louarn P. , Owen C. J. , Horbury T. S. , Prech L. , Durovcova T. , Barthe A. , Rouillard A. P. , Kasper J. C. , Bale S. D. , Bruno R. , O’Brien H. , Evans V. , Angelini V. , Larson D. , Livi R. , Lavraud B. , Andre N. , Genot V. , Penou E. , Mele G. , Fortunato V. 
Published: September 2021

Context.Rapid polarity reversals of the radial heliospheric magnetic field were discovered by Ulysses and they are now frequently observed as a common near-Sun phenomenon by NASA’s Parker Solar Probe (PSP). Other solar wind missions, including ESA-NASA Solar Orbiter (SolO), also observe similar phenomena. The nature of these fluctuations is unclear, and the relation between the “switchbacks” observed near the Sun and similar events observed at 1 AU is unknown.Aims.We make a detailed case study of the SolO plasma and magnetic field data obtained in a region that is magnetically connected to a coronal hole. We aim to check whether such fluctuations might have the same origin as the “switchbacks” observed by PSP.Methods.We used PSP magnetic field and plasma data to support our analysis of SolO data. We used the magnetic field data, electron pitch angle distributions, proton velocity distribution functions, andα-particle parameters measured by SolO to perform a detailed analysis of the observed solar wind perturbations.Results.On 27 September 2020, PSP and SolO were located around the same Carrington longitude and their latitudinal separation was very small. Solar wind plasma and magnetic field data during this time interval confirms that (at least at certain times) the solar wind observed by both spacecraft does originate from the same coronal hole region and that during these time intervals, SolO experiences several short variations similar to the “switchbacks” regularly observed by PSP.Conclusions.The suprathermal electron pitch angle distributions andα-particle speed variations indicate that the magnetic field line was bent by 180° by solar wind velocity shear. Variations in electron and proton velocity distribution functions suggest that bent field lines reconnect with each other, producing flux ropes. The observed flux ropes might be the surviving and modified remains of the switchbacks created near Sun and observed by PSP.
Modeling and simulation of complex flows using Basset digital filters
Authors: Lahboub D. , Bakak A. , Lotfi M. , Heyd R. , Koumina A. 
Published: September 2021

Taking into account the Basset force (memory term), in the balance of the forces exerted on a colloidal particle (CP) suspended in a fluid, results in an equation of motion of integrodifferential form. This type of equation allows for example to modeling a colloidal particle settling in an quiescent fluid or in a fluid flowing at low particle’s Reynolds number. It also allows to study the transport of pathogens via aerosols, thus giving access to important information on the airborne propagation of respiratory viruses, such as COVID-19 and its variants for example.
Most studies of the PCs motion in a fluid are usually simplified by not taking into account the Basset memory force, as it considerably complicates the numerical solution of the equations of motion of these PCs. This simplification can lead to considerable errors in the evaluation of the trajectory and velocity of the PCs, which can subsequently lead to errors in the calculation of the physical and rheological properties of colloidal suspensions.
The present study deals with the numerical solution of Basset’s integro-differential equation, by two significantly different approaches, namely : a piecewise linear approximation (PLA) and the method of Basset numerical filters (BNF). These methods are first exposed and compared on test cases, they are then applied to the study of the sedimentation of spherical PCs with micrometer radii. This study has shown that the usual dynamics of PCs, which does not take into account the Basset memory term, can be very different from the exact dynamics using the Basset force. The BNF approach is finally applied to the study of the motion of PCs driven by flows through complex geometries (pipes, porous media, …).
Determination of temperature-dependent Fermi resonance in acetonitrile–water binary solution by two-dimensional correlation Raman spectroscopy
Authors: Cao Xianwen , Xing Lu , Wang Ying , Wang Shenghan , Sun Chenglin , Men Zhiwei 
Published: September 2021

Acetonitrile (AN), as an organic solvent, has a wide range of applications. The C≡N stretching vibration mode (ν2) and the combination mode (ν3 + ν4) are coupled by Fermi resonance (FR). In this work, the phase transition and the interaction mechanism of the 60% AN–water binary solution (AN–Water) were analyzed by calculating FR parameters and two-dimensional correlation Raman spectroscopy (2DCRS). The change in the ν2 band and the base bands ν3 and ν4 caused energy transfer by anharmonic interaction, which led to a change in FR parameters. With a reduced temperature, the energy transfer was caused by microheterogeneity and the energy transfer effect (293–273 K), the phase separation (263–233 K), and the phase transition of AN (223–173 K). The 2DCRS and Gaussian deconvolution provided more information on FR, which revealed the interaction mechanism of the Fermi doublet. The polarity and binding modes of molecules provided a new perspective for analyzing the transmission of electrons and ions in the electrolyte at different temperatures.
Detailed quasiclassical dynamics of the F− + CH3Br reaction on an ab initio analytical potential energy surface
Authors: Tajti Viktor , Győri Tibor , Czakó Gábor 
Published: September 2021

Dynamics and mechanisms of the F− + CH3Br(v = 0) → Br− + CH3F (SN2 via Walden inversion, front-side attack, and double inversion), F− + inverted-CH3Br (induced inversion), HF + CH2Br− (proton abstraction), and FH⋯Br− + 1CH2 reactions are investigated using a high-level global ab initio potential energy surface, the quasiclassical trajectory method, as well as non-standard configuration- and mode-specific analysis techniques. A vector-projection method is used to identify inversion and retention trajectories; then, a transition-state-attack-angle-based approach unambiguously separates the front-side attack and the double-inversion retention pathways. The Walden-inversion SN2 channel becomes direct rebound dominated with increasing collision energy as indicated by backward scattering, initial back-side attack preference, and the redshifting of product internal energy peaks in accord with CF stretching populations. In the minor retention and induced-inversion pathways, almost the entire available energy transfers into product rotation–vibration, and retention mainly proceeds with indirect, slow double inversion following induced inversion with about 50% probability. Proton abstraction is dominated by direct stripping (evidenced by forward scattering) with CH3-side initial attack preference, providing mainly vibrationally ground state products with significant zero-point energy violation.
Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer
Authors: Aggarwal Ritesh K. , Luchtel Rebecca A. , Machha Venkata , Tischer Alexander , Zou Yiyu , Pradhan Kith , Ashai Nadia , Ramachandra Nandini , Albanese Joseph M. , Yang Jung-in , Wang Xiaoyang , Aluri Srinivas , Gordon Shanisha , Aboumohamed Ahmed , Gartrell Benjamin A. , Hafizi Sassan , Pullman James , Shenoy Niraj 
Published: September 2021

Significance
This study demonstrates that underexpression of succinate dehydrogenase (SDH) subunits resulting in accumulation of oncogenic succinate is a common, adverse, epigenetic modulating feature in clear cell renal cell carcinoma (ccRCC), during pathogenesis and progression. The study sheds light on the mechanisms of down-regulation of SDH subunits in ccRCC and deciphers the consequent oncogenic effects. It shows that functional SDH deficiency is a common feature of ccRCC (∼80% of all kidney cancers), and not just limited to the 0.05 to 0.5% of kidney cancers with germline SDH mutations.
The impact of crowdsourcing and online collaboration in professional translation
Authors: Jiménez-Crespo Miguel A. 
Published: September 2021

Abstract
The emergence of crowdsourcing has opened up novel ways to initiate, produce and deliver translations in our
digitally connected world. New practices and processes brought up by these phenomena have undeniably impacted different
collectives with an interest in translation, such as language service providers (LSPs), professionals, and Translation Studies
(TS). It has also been argued that crowdsourcing can impact public perceptions of translation, rising ethical concerns, issues
related to the visibility of translation, or whether everyone can potentially translate (McDonough-Dolmaya 2012). This paper analyzes its potential impact on the realm of professional translation, an issue
raised several years ago by a European Union Commission publication (2012, 37–38). It critically analyzes whether the much-feared
socioeconomic and socio-professional impact on working conditions of professionals is underway or not. It represents an attempt at
charting the potential influence of crowdsourcing on the profession through a critical review of existing literature and industry
publications.
“All the pieces matter”
Authors: Ortiz García Javier 
Published: September 2021

ResumenEste artículo aborda el problema de la traducción del lenguaje vulgar desde una perspectiva práctica. Para ello, se emplean ejemplos de tres episodios diferentes de la aclamada serieThe Wire, donde el uso de este tipo de lenguaje aparece en todos los estamentos sociales y profesionales de personajes. En primer lugar, se contextualiza la serie dentro del espectro televisivo del que procede, el estadounidense, y se analiza la importancia que en ella tiene el empleo del lenguaje vulgar. A continuación, se estudian las diferentes posibilidades estratégicas que el traductor puede emplear a la hora de traducir textos en los que aparece el lenguaje vulgar de manera reiterada. Por último, se examinan cualitativamente los tres ejemplos de la serie seleccionados y sus traducciones oficiales. Se concluye el estudio ofreciendo alternativas a esa traducción disponible en el mercado con el fin de ilustrar un posible visionado del programa más adecuado en el que se ha prestado especial atención al empleo del lenguaje vulgar traducido.
The expression of emotions in Kunbarlang and its neighbours in the multilingual context of western and central Arnhem Land
Authors: O’Keeffe Isabel , Singer Ruth , Coleman Carolyn 
Published: September 2021

AbstractThis paper explores how emotions are expressed in the endangered Gunwinyguan language Kunbarlang and compares these expressions to those in the neighbouring Gunwinyguan language Bininj Kunwok, and neighbouring languages from other language families, Mawng (Iwaidjan) and Ndjébbana (Maningridan). As well as considering body-based emotion expressions and the tropes (metaphors and metonymies) they instantiate, we consider the range of other (non-body-based) expressions and tropes available in each language. These provide an important point of comparison with the body-part expressions, which are limited to expressions based on noun incorporation in the Gunwinyguan languages and, correspondingly, a more limited range of tropes. By outlining and comparing the linguistic tropes used to express emotions in these four languages in the highly multilingual yet socioculturally unified context of western Arnhem Land, we aim to shed further light on the relationships between linguistic figurative features and conceptual representations of emotions.
Feeling through your chest
Authors: Bednall James 
Published: September 2021

AbstractThis article explores the expression and conceptualisation of emotions in Anindilyakwa (Gunwinyguan, north-east Arnhem Land). Fundamental to the emotional lexicon of this language is the widespread use of body parts, which frequently occur in figurative expressions. In this article I examine the primary body parts that occur in emotion descriptions in both literal (physical) and figurative expressions. Particular attention is given toyukudhukudha /-werrik- ‘chest’, the body part conceptualised as the primary site of emotion in Anindilyakwa and the most productive body-related morpheme used in emotion compounds. I consider the role of the chest and other productive body parts that occur in emotion compounds, and examine the metonymic and metaphorical devices that contribute to the expression of these emotional states. In doing so, I propose a number of overarching and widespread tropes that hold across different body-part compounds, and briefly contextualise these in relation to the emotion description systems of other closely-related (Gunwinyguan) languages.