bluuebunny/crossref_metadata_2025_split huggingface dataset:
PONTOS JURÍDICOS DO AMBUSH MARKETING: DIÁLOGOS ENTRE A PUBLICIDADE DE EMBOSCADA E O DIREITO PENAL
Authors: Carvalho Ivan Lira de 
Published: December 2021

Tem o presente trabalho a finalidade de abordar as ligações e os distanciamentos entre o Direito Penal e o ambush marketing, instituto ainda em consolidação no universo da publicidade. Para tanto, é usado como objeto de análise o conjunto de tipos penais introduzidos no sistema penal brasileiro pela Lei nº 12.663, de 05 de junho de 2012, com o objetivo de dar suporte jurídico a três eventos de especial importância econômica e social ocorridos no Brasil nos anos de 2013 e 2014 (Copa das Confederações FIFA 2013, a Jornada Mundial da Juventude 2013 e a Copa do Mundo FIFA 2014). A mencionada lei comporta, dentre outros tipos penais, os crimes de marketing de emboscada por intrusão e marketing de emboscada por associação. Um dos motivos inspiradores da presente análise foi a escolha, pelo legislador nacional, de normas penais incriminadoras como vigência temporária, fato incomum no sistema brasileiro, que por ter forte vinculação ao princípio da legalidade, é pouco afeito a variações como as de normas temporárias ou excepcionais.
LINEAMENTOS JUSFILOSÓFICOS DA JURISDIÇÃO: DO POSITIVISMO AO PÓS-POSITIVISMO PROCEDIMENTAL
Authors: Maciel Pinheiro Pereira Carlos André , Solon Borges Andressa , De Medeiros Oliveira Nathânia de Medeiros Oliveira 
Published: December 2021

Este artigo pretende estudar um modelo de decisão judicial apto a corresponder aos interesses da cidadania pluralista. Faz uso do método dialético em um primeiro momento e dedutivo no subsequente. É uma pesquisa qualitativa e normativa. Utiliza fontes de pesquisa doutrinária com ênfase em autores da filosofia do direito e teoria do direito constitucional. Entende que as teorias do positivismo de Hart, do pós-positivismo de Dworkin e Alexy e do pragmatismo jurídico de Posner são insuficientes para justificar a legitimidade das decisões. Encontra em Habermas um modelo procedimental de jurisdição que permite o diálogo democrático e cooperativo entre os atores processuais. Em seguida, investiga a aplicação da teoria habermasiana na jurisdição ordinária com ênfase no processo penal e na jurisdição constitucional com suporte em Ricardo Tinoco de Góes. Por fim, sugere que a proposta de Habermas seja utilizada para futuras investigações sobre a aplicabilidade na legislação brasileira.
O PRINCÍPIO DA COOPERAÇÃO NO ÂMBITO DO PROCESSO ADMINISTRATIVO DISCIPLINAR
Authors: ARAÚJO SAMMARA COSTA PINHEIRO GUERRA DE , Braga Lima Ana Priscyla 
Published: December 2021

RESUMO
O presente artigo desenvolve uma investigação acerca da possibilidade ou não da aplicação do princípio da cooperação, também chamado de princípio da colaboração, no âmbito do processo administrativo disciplinar. Para isso, aborda-se a importância do processo administrativo no contexto da Administração Pública contemporânea. Analisa-se, ainda, o espírito do Novo Código de Processo Civil e conceitua um dos seus fundamentos basilares, a cooperação. Verifica-se a aplicabilidade subsidiária e supletiva desse Código a todos os processos administrativos regidos por outras leis, inclusive dentro do processo administrativo disciplinar. Por fim, delimita-se o princípio do devido processo legal e o princípio da cooperação processual no âmbito do processo administrativo, determinando seus efeitos e deveres. Para a realização desse estudo foi utilizada a metodologia bibliográfica, expondo pensamentos de autores que guardem pertinência temática.

Palavras-chave: Processo administrativo. Novo código de processo civil. Princípio da cooperação.
O NOVO CONCEITO DE PESSOA COM DEFICIÊNCIA E SUA APLICABILIDADE POR ÓRGÃOS FISCALIZADORES OU RECONHECEDORES DE DIREITOS ESTATAIS
Authors: SAMPAIO RICARDO ALVES , Talarico Cahue Alonso 
Published: December 2021

O presente artigo tem como objetivo abordar a mudança conceitual de pessoa com deficiência e a dificuldade de assimilação desta alteração nos órgãos de fiscalização ou reconhecedores de direitos estatais. A Convenção de Nova Iorque, sobre direitos da pessoa com deficiência, que ingressou no ordenamento jurídico brasileiro com status de normal constitucional, conforme o processo legislativo previsto no art. 5º, § 3º, da Constituição Federal, mudou substancialmente as normas brasileiras. A partir de então, pretende-se que o processo permanente de inclusão seja mais efetivo, derrubando intolerâncias, perseguindo os ideais de igualdade, universalização de direitos e a efetiva tutela dos direitos da pessoa com deficiência, já que esta tem sua situação mais ou menos agravada, tendo em vista as condições do meio lhe sejam mais ou menos favoráveis. Destarte, serão analisados dois órgãos de fiscalização, as Delegacias do Trabalho e o Ministério Público do Trabalho e o Instituto Nacional do Seguro Social – INSS, enquanto reconhecedor de direitos. Para tanto, observar-se-á a legislação que vem sendo aplicada por estes órgãos estatais, após a referida mudança conceitual.
Palavras-chave: Conceito de pessoa com deficiência. Órgãos de fiscalização estatal. Benefício assistencial; Convenção sobre os Direitos da Pessoa com Deficiência.
A DEVOLUÇÃO DOS VALORES RECEBIDOS POR BENEFÍCIOS PREVIDENCIÁRIOS CONCEDIDOS POR TUTELA ANTECIPADA POSTERIORMENTE REVOGADA: ANÁLISE JURISPRUDENCIAL DOS TRIBUNAIS SUPERIORES BRASILEIROS
Authors: Balduino Maria Clara de Jesus Maniçoba 
Published: December 2021

RESUMO: A possibilidade de devolução dos valores recebidos por benefícios previdenciários concedidos mediante tutela antecipada que venha a ser posteriormente revogada é tema que tem ganhado notoriedade e relevância na comunidade jurídica diante das divergências jurisprudenciais que tem se verificado nos tribunais brasileiros ao julgar tais demandas. As ações que versam sobre a concessão de benefícios previdenciários em regra demandam urgência diante da situação de necessidade e desamparo em que se encontra o requerente; além disso, o lapso temporal para que o processo previdenciário seja concluído pode colocar em risco o direito do beneficiário, podendo levar a ocorrência de um dano irreparável e irreversível na demanda. Nessas situações, não é incomum que seja requerida a antecipação de tutela para que o direito possa ser satisfeito em tempo hábil, o que ocorre no entanto é que tal decisão se dá meio de cognição sumária, e o caráter provisório da tutela implica em sua possível reversibilidade posterior. Em caso de revogação, a pergunta que se impõe é: cabe ou não a devolução desses valores? Diante disso, o presente artigo busca analisar essa possibilidade a partir de um estudo sobre instituto da tutela antecipada no processo previdenciário, verificando como os tribunais superiores brasileiros vem se manifestando sobre o assunto. Utiliza como procedimentos metodológicos a pesquisa bibliográfica em meio impresso e virtual.
PALAVRAS-CHAVE: DIREITO PREVIDENCIÁRIO. BENEFÍCIOS PREVIDENCIÁRIOS.PROCESSO PREVIDENCIÁRIO. REVOGAÇÃO DE TUTELA ANTECIPADA. DEVOLUÇÃO DOS VALORES.
Quorum Sensing Regulation as a Target for Antimicrobial Therapy
Authors: Ruiz Caterine Henríquez , Osorio-Llanes Estefanie , Trespalacios Mayra Hernández , Mendoza-Torres Evelyn , Rosales Wendy , Gómez Carlos Mario Meléndez 
Published: December 2021

:
Some bacterial species use a cell-to-cell communication mechanism called Quorum Sensing
(QS). Bacteria release small diffusible molecules, usually termed signals which allow the activation
of beneficial phenotypes that guarantee bacterial survival and the expression of a diversity of virulence
genes in response to an increase in population density. The study of the molecular mechanisms
that relate signal molecules with bacterial pathogenesis is an area of growing interest due to its use as
a possible therapeutic alternative through the development of synthetic analogues of autoinducers as a
strategy to regulate bacterial communication as well as the study of bacterial resistance phenomena,
the study of these relationships is based on the structural diversity of natural or synthetic autoinducers
and their ability to inhibit bacterial QS, which can be approached with a molecular perspective from
the following topics: i) Molecular signals and their role in QS regulation; ii) Strategies in the modulation
of Quorum Sensing; iii) Analysis of Bacterial QS circuit regulation strategies; iv) Structural evolution
of natural and synthetic autoinducers as QS regulators. This mini-review allows a molecular
view of the QS systems, showing a perspective on the importance of the molecular diversity of autoinducer
analogs as a strategy for the design of new antimicrobial agents.
Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms
Authors: Shaito Abdullah , Kobeissy Firas , Haidar Muhammad Ali , Ibeh Stanley , Shakkour Zaynab , Reslan Mohammad Amine , Nwaiwu Judith , Moqidem Yomna Adel , Sader Georgio , Nickles Rachel G. , Babale Ismail , Jaffa Aneese A. , Salama Mohamed 
Published: December 2021

:Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least partly, via signals initiated by injured neurons. Activated microglia, thereby, contribute to both neuroprotection and neuroinflammation. However, sustained microglial activation initiates a chronic neuroinflammatory response which can disturb neuronal health and disrupt communications between neurons and microglia. Thus, microglia-neuron crosstalk is critical in a healthy brain as well as during states of injury or disease. As most studies focus on how neurons and microglia act in isolation during neurotrauma, there is a need to understand the interplay between these cells in brain pathophysiology. This review highlights how neurons and microglia reciprocally communicate under physiological conditions and during brain injury and disease. Furthermore, the modes of microglia-neuron communication are exposed, focusing on cell-contact dependent signaling and communication by the secretion of soluble factors like cytokines and growth factors. In addition, how microglia-neuron interactions could exert either beneficial neurotrophic effects or pathologic proinflammatory responses are discussed. We further explore how aberrations in microglia-neuron crosstalk may be involved in central nervous system (CNS) anomalies, namely: traumatic brain injury (TBI), neurodegeneration, and ischemic stroke. A clear understanding of how the microglia-neuron crosstalk contributes to the pathogenesis of brain pathologies may offer novel therapeutic avenues of brain trauma treatment.
Treating Depression and other Serotonin Deficiency Brain Disorders with
Tryptophan
Authors: Haleem Darakhshan Jabeen 
Published: December 2021

:
A deficit in brain serotonin (5-hydroxytryptamine; 5-HT) is implicated in a number of
psychiatric illnesses, including depression. The treatment efficacy of this highly prevalent brain disorder
is not adequate largely due to the depletion of serotonin stores. Tryptophan, an essential amino
acid, is the sole precursor of serotonin; its systemic or oral administration increases serotonin
synthesis because tryptophan hydroxylase, the rate-limiting enzyme of 5-HT biosynthesis, is physiologically
unsaturated with its substrate. The present article targets the importance of tryptophan
supplementation in treating serotonin deficiency and improving therapeutic intervention for depression
and other serotonin deficiency brain disorders.
Investigation of the Effect of Prunus Amygdalus Amara on the Expression
of some Genes of Apoptosis and Immortality in Breast Cancer Cells (MCF-
7)
Authors: Karimabad Mojgan Noroozi , Abdolahi-Majd Maryam , Hassanshahi Gholamhossein , Vatanparast Mahboubeh 
Published: December 2021

Background:
Anti-cancer effects of almond nuts or oil have been approved, but there
are a few pieces of research that have evaluated, in detail, almond and other seeds' effects on cancer.
Therefore, in the present project, the aim was to explore the regulatory effect of the bitter almond
extract (Prunus amygdalus Batsch) on the apoptotic and anti-cancer potency of MCF-7 cells.

Objectives:
In the current experimental research, the Almond effect on MCF7 cells was evaluated
by investigating the expression and the balance between Bcl-2, Bax genes to unmark the potential
molecular mechanism.

Methods:
For 24 and 48h, the MCF7 cells were treated with the bitter almond extract (187.5-3000
μg/mL). MTT assay was used to assess the viability, and Real-time-PCR was applied to determine
the expression of Bax and Bcl-2, facing β-actin.

Results:
Our results revealed a significant difference between different extract concentrations on
the viability of MCF7 cell lines in 24 and 48 h; cell viability decreased time-dependently (P <
0.05). After 24 and 48h of extract facing MCF7 cells, the evaluated IC50 value was 3000 and 1500
μg/mL, respectively. Based on Real Time-PCR analysis, after 24 and 48 h, the mRNA levels of
BCL-2 decreased by the extract, whereas Bax was in the MCF-7 cell line.

Conclusion:
From the results, it can be concluded that bitter almond extract has anti-cancer properties
that may influence the apoptotic pathways by regulating relative gene expression.
A Risk-Based Clinical Decision Support System for Patient-Specific Antimicrobial Therapy (iBiogram): Design and Retrospective Analysis
Authors: Müller Lars , Srinivasan Aditya , Abeles Shira R , Rajagopal Amutha , Torriani Francesca J , Aronoff-Spencer Eliah 
Published: December 2021

Background
There is a pressing need for digital tools that can leverage big data to help clinicians select effective antibiotic treatments in the absence of timely susceptibility data. Clinical presentation and local epidemiology can inform therapy selection to balance the risk of antimicrobial resistance and patient risk. However, data and clinical expertise must be appropriately integrated into clinical workflows.

Objective
The aim of this study is to leverage available data in electronic health records, to develop a data-driven, user-centered, clinical decision support system to navigate patient safety and population health.

Methods
We analyzed 5 years of susceptibility testing (1,078,510 isolates) and patient data (30,761 patients) across a large academic medical center. After curating the data according to the Clinical and Laboratory Standards Institute guidelines, we analyzed and visualized the impact of risk factors on clinical outcomes. On the basis of this data-driven understanding, we developed a probabilistic algorithm that maps these data to individual cases and implemented iBiogram, a prototype digital empiric antimicrobial clinical decision support system, which we evaluated against actual prescribing outcomes.

Results
We determined patient-specific factors across syndromes and contexts and identified relevant local patterns of antimicrobial resistance by clinical syndrome. Mortality and length of stay differed significantly depending on these factors and could be used to generate heuristic targets for an acceptable risk of underprescription. Combined with the developed remaining risk algorithm, these factors can be used to inform clinicians’ reasoning. A retrospective comparison of the iBiogram-suggested therapies versus the actual prescription by physicians showed similar performance for low-risk diseases such as urinary tract infections, whereas iBiogram recognized risk and recommended more appropriate coverage in high mortality conditions such as sepsis.

Conclusions
The application of such data-driven, patient-centered tools may guide empirical prescription for clinicians to balance morbidity and mortality with antimicrobial stewardship.
A Virtual Supermarket Program for the Screening of Mild Cognitive Impairment in Older Adults: Diagnostic Accuracy Study
Authors: Yan Mingli , Yin Huiru , Meng Qiuyan , Wang Shuo , Ding Yiwen , Li Guichen , Wang Chunyan , Chen Li 
Published: December 2021

Background
Mild cognitive impairment (MCI) is often a precursor of dementia, and patients with MCI develop dementia at a higher rate than healthy older adults. Early detection of cognitive decline at the MCI stage supports better planning of care and interventions. At present, the use of virtual reality (VR) in screening for MCI in older adults is promising, but there is little evidence regarding the use of virtual supermarkets to screen for MCI.

Objective
The objectives of this study are to validate a VR game–based test, namely, the Virtual Supermarket Program (VSP), for differentiating patients with MCI and healthy controls and to identify cutoff scores for different age levels.

Methods
Subjects were recruited from several nursing homes and communities in Changchun, China. They were divided into a healthy control group (n=64) and an MCI group (n=62). All subjects were administered the VSP and a series of neuropsychological examinations. The study determined the optimal cutoff, discriminating validity, concurrent validity, and retest reliability of the VSP. We used the area under the receiver operating characteristic curve (AUC) to evaluate the discriminating validity and obtain the optimal cutoff values. Pearson correlation analysis and the intraclass correlation coefficient were used to evaluate the concurrent validity and retest reliability, respectively.

Results
A cutoff score of 46.4 was optimal for the entire sample, yielding a sensitivity of 85.9% and specificity of 79.0% for differentiating individuals with MCI and healthy controls, and the AUC was 0.870 (95% CI 0.799-0.924). The median index of VSP score was 51.1 (range 42.6-60.0). There was a moderate positive correlation between the VSP total score and Mini-Mental State Examination score (r=0.429, P<.001). There was a strong positive correlation between VSP total score and Montreal Cognitive Assessment score (r=0.645, P<.001). The retest reliability of the VSP was feasible (r=0.588, P=.048).

Conclusions
The VSP is interesting and feasible for subjects. It shows high sensitivity and specificity for the identification of MCI in older adults, which makes it a promising screening method. The VSP may be generalized to older adults in other countries, although some cultural adaptation may be necessary.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2000040074; https://www.chictr.org.cn/showprojen.aspx?proj=64639
Особливості клінічних проявів нової коронавірусної інфекції COVID-19 у хворих при їх госпіталізації під час епідемії залежно від віку
Authors: Trykhlib V.I. , Tsiurak N.R. , Beliaeva K.P. , Lysenko T.I. , Yeroshenko A.O. , Martynchyk O.S. 
Published: December 2021

У статті поданий огляд літератури та дані особистого дослідження стосовно клінічних проявів нової коронавірусної інфекції у хворих під час епідемії COVID-19 залежно від їх віку при госпіталізації. Встановлено, що більшість хворих скаржились на сухий або малопродуктивний кашель, помірну загальну слабість. Кашель частіше був відсутній у хворих віком 18–30 років. Вірогідно частіше відзначали сухий кашель пацієнти віком 31–40 років (p < 0,05). Малопродуктивний кашель відзначався не часто, але був характерним для всіх вікових груп і частіше спостерігався у хворих віком 51–60 років. Вологий кашель спостерігався частіше у хворих віком понад 60 років. Біль у грудній клітці реєструвався в пацієнтів віком понад 60 років (р < 0,05). Встановлено, що частота задишки збільшувалася з віком. Частіше задишка реєструвалась у пацієнтів, старших за 60 років. В осіб молодого віку 18–30 років задишка не відзначалась. У половини хворих віком 18–30 років гарячки не було. При госпіталізації в середньому температура була в межах норми або субфебрильною, останнє найчастіше спостерігалося в пацієнтів віком 41–50 років (p < 0,05). Частота фебрильної температури зростає у хворих зі збільшенням віку. Суттєвої різниці за частотою піретичної температури серед усіх вікових груп не було. На помірну слабкість скаржилось більше хворих віком понад 30 років, а на виражену — хворі, старші за 40 років. На першіння в горлі частіше скаржились молодші хворі. У старших пацієнтів першіння практично не реєструвалось (р > 0,05). Вірогідно частіше біль у грудній клітці реєструвався в пацієнтів, старших за 60 років. У молодих пацієнтів 18–30 і 31–40 років біль у грудній клітці не відзначався.
Effects of cropping system and varieties on the rice growth and yield in acid sulphate soils of tidal swampland
Authors: Khairullah Izhar , Annisa Wahida , Subagio Herman , Sosiawan Hendri 
Published: December 2021

Swampland plays a critical function in agriculture, specifically in growing rice production. The study aimed to determine the effects of cropping systems and varieties on the rice growth and yield in acid sulfate soil of tidal swampland. The experiment was conducted in a potential acid sulphate soils in Kapuas Regency, Central Kalimantan Province. The experiment was arranged in a split plot design with three replications. The main plot consisted of three HYV’s of rice, namely Inpara 8, Inpari 32, and Margasari. The subplot consisted of five cropping systems, namely, Jarwo 2:1A, Jarwo 2:1B, Jarwo 2:1C, Hazton, and Tegel. The plot size was 4 m x 5 m. The variables observed included initial soil properties, plant growth, and yield components. The jajar legowo cropping system in this study was not able to increase rice yields in acid sulphate soil. There was an interaction effect of cropping systems and varieties on the plant height and number of tillers at vegetative phase. At generative and pre-harvest phases, there was significant single effect of variety and cropping system in the planting height and number of tillers, respectively. Both cropping system and variety significantly affected the number of panicles per hill, while panicle length, grain per panicle and grain yield were only affected by variety. There was no significant effect of both factors on the number of filled grains per panicle. Inpara 8 variety achieved the highest grain yield, which was 6.78 ton.ha-1 or equivalent to 4.34 ton.ha-1 of 14 % water content.
К спорным вопросам истории Бурят-Монголии: позиция В. Ф. Аханянова
Authors:   Archive of the Russian Academy of Sciences (34, Novocheremushkinskaya St., 117218 Moscow, Russian Federation), Kiselyov Mikhail Yu. 
Published: December 2021

The aim of the present study is to examine the report “On controversial issues in the history of Buryat-Mongolia” made by V. F. Akhanianov at the Institute of History of the Communist Academy. Its focusis on thequestions raised during the discussions in Verkhneudinsk in July 1934 that Akhanianov’s report deals with. The source for the study is the transcript of the report, dated September 7, 1934,that is kept in the Archive of the Russian Academy of Sciences. Results. The scholarpresented his criticisms of some participants’ opinions but, also, his own views of the issues on the agenda, such as feudalism in the historical context of Buryat-Mongolia, the Russian Empire’s colonial policy, Prussian or American ways of development, forms of exploitation that existed before 1917, October Revolution and Civil War in Buryat-Mongolia, and land reform. Also, the report includes a significant number of ideological statements, which was typical of public speeches in the mid-1930s. The report shows Akhanianov’s expertise in the history of Buryat-Mongolia and his genuine interest in restoring historical justice in the assessment of individual stages in the Republic’s development. In terms of the studies of the historical past of Buryatia, of relevance is also the discussion of the report that followed and the speaker’s concluding remarks. Conclusion.The material presented in the paper contributes to the database in the field of research and is of interest for further studies.