bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Diagnosis and Results of Enzyme Replacement Therapy in the Patient with Mucopolysaccharidosis Type VI: Clinical Case
Authors: Ivanov Dmitry V. , Ostrun Anna I. , Kenis Vladimir M. , Markova Tatiana V. , Zakharova Ekaterina Yu. 
Published: December 2021

Background. Mucopolysaccharidosis type VI (MPS VI, Maroteaux–Lamy syndrome) is rare autosomal-recessive multisystem disease, one of the group of lysosomal storage diseases. The MPS VI pathogenesis is determined by arylsulfatase B enzyme deficiency caused by mutations in the ARSB gene. There are only few published clinical examples of this disease that covers the results of early enzyme replacement therapy (ERT) onset.Clinical case description. The child was suspected to have lysosomal storage disease at the age of 1.5 months, it was based on microscopic analysis of blood smears: Alder abnormality was revealed (granulations and red-violet inclusions in neutrophils, monocytes, lymphocytes cytoplasm). The diagnosis was confirmed at the age of 3 months: increased glycosaminoglycans (GAGs) concentration in the urine, arylsulfatase B activity decrease in dried blood spots, and pathogenic variant c.943C>T (p. R315X) in the ARSB gene in homozygous state were revealed. ERT with galsulfase was started at the age of 7 months. There was decrease in excretion of GAGs in urine to normal level after 9 and 15 months of therapy. Normal growth and body proportions for the patient’s age were determined 3 years after continuous ERT. However, there was progression of multiple dysostosis and joint stiffness, as well as eyes lesion.Conclusion. Early ERT onset cannot completely stop MPS VI progression but it allows to reduce the severity of several symptoms and improves patient’s quality of life.
Rectal cream “Hem” (as suppositories) in treatment of chronic abacterial prostatitis
Authors: Naumov N. P. , Scheplev P. A. , Martazinova S. К. 
Published: December 2021

Chronic prostatitis is one of the most common disorders in men of reproductive age. In 5-10 % of cases, prostatitis is caused by bacterial infection. In 80-90 % of patients, bacterial agent cannot be detected, and chronic abacterial prostatitis is diagnosed per the National Institute of Health classification (NIH, 1995).Even with combination therapy using drugs of different groups, chronic prostatitis is a recurrent disorder and can lead to development of symptoms in the lower urinary tract and chronic pelvic pain syndrome decreasing patients' quality of life.Phytotherapy and beekeeping products with anti-inflammatory, pain-relieving, immunostimulating effects has a certain place in the treatment of chronic prostatitis.The study objective is to evaluate the effectiveness and safety of rectal cream “Hem” (as suppositories) manufactured by Russian company ADONIS CNPG and TM LCC in patients with chronic abacterial prostatitis.
EXTENSÃO DE OCORRÊNCIA DO CAMARÃO NÃO NATIVO Penaeus monodon FABRICIUS, 1798 (DECAPODA: PENAEIDAE) NO LITORAL AMAZÔNICO BRASILEIRO = THIS STUDY PROVIDES NEW RECORDS OF THE NON-NATIVE SPECIES Penaeus monodon FABRICIUS, 1798, IN THE BRAZILIAN AMAZON COAST THROUGH CATCHES ON STATE OF MARANHÃO
Authors: Andrade Kele Sousa Pires , Filgueira Carlos Henrique Marinho dos Santos , Nunes Jorge Luiz Silva 
Published: December 2021

O presente estudo fornece três novos registros de ocorrência da espécie não nativa Penaeus monodon Fabricius, 1798 no Litoral Amazônico Brasileiro, a partir de capturas no estado do Maranhão.AbstractThis study provides new records of the non-native species Penaeus monodon Fabricius, 1798, in the Brazilian Amazon Coast through catches on State of Maranhão.
BIOLOGIA REPRODUTIVA DE Neomarica northiana (SCHNEEV) SPRAGUE (IRIDACEAE): “MERANTHIA” - UM CASO ESPECIAL DE POLINIZAÇÃO = REPRODUCTIVE BIOLOGY OF Neomarica northiana (SCHNEEV) SPRAGUE (IRIDACEAE)
Authors: Silva André Luiz Gomes da 
Published: December 2021

Este trabalho teve como objetivo estudar a biologia reprodutiva de Neomarica northiana (Schneev) Sprague (Iridaceae), erva perene que ocorre nas restingas do estado do Rio de Janeiro. A flor desta espécie apresenta três unidades funcionais de polinização denominada “meranthia”. O recurso floral oferecido aos polinizadores é a substância lipídica exsudada na base das tépalas. Análise de cromotografia gasosa das tépalas indicou a presença de limoneno. As flores de N. northiana são polinizadas exclusivamente por abelhas poliléticas de grande porte, Xylocopa sp.. Neomarica northiana é autocompatível. A produção de frutos por polinização natural foi maior do que a produção por polinização manual cruzada. A taxa de fecundidade é de 0,47. Neomarica northiana apresenta crescimento clonal que pode ocorrer de duas formas distintas, por meio do caule rizomatoso e por meio de bulbilhos formados na axila das brácteas.AbstractThe objective of this research was to evaluate the reproductive biology of Neomarica northiana (Iridaceae), a perennial herb that occurs in the Atlantic Coast restingas (humid subtropical broadleaf forest) of the state of Rio de Janeiro. Each flower of this species has three functional pollinating units called “meranthia”. The main floral resource provided to bees by Neomarica northiana is a lipid substance exuded at the base of the tepals. Gas-chromatographic analysis of tepal samples revealed the presence of limonene. Flowers of N. northiana are pollinated exclusively by large bodied species of bees (Xylocopa sp.). Fruit production from natural pollination is higher than from manual pollination. The fecundity rate is 0.47. Neomarica northiana has clonal growth, which may occur by means of the rhizomatous stem, which produces offshoots close to one another; or by means of axillary bulbils.
Novel Analytical Solution and Type-Curves for Lost-Circulation Diagnostics of Drilling Mud in Fractured Formation
Authors: Albattat Rami , Hoteit Hussein 
Published: December 2021

Abstract
Loss of circulation is a major problem that often causes interruption to drilling operations, and reduction in efficiency. This problem often occurs when the drilled wellbore encounters a high permeable formation such as faults or fractures, leading to total or partial leakage of the drilling fluids. In this work, we present a novel semi-analytical solution and type-curves that offer a quick and accurate diagnostic tool to assess the lost-circulation of Herschel-Bulkley fluids in fractured media. Based on the pressure and mud loss trends, the tool can estimate the effective fracture conductivity, the cumulative mud-loss volume, and the leakage period. The behavior of lost-circulation into fractured formation can be assessed using analytical methods that can be deployed to perform flow diagnostics, such as the rate of fluid leakage and the associated fracture hydraulic properties. In this study, we develop a new semi-analytical method to quantify the leakage of drilling fluid flow into fractures. The developed model is applicable for non-Newtonian fluids with exhibiting yield-power-law, including shear thickening and thinning, and Bingham plastic fluids. We propose new dimensionless groups and generate novel dual type-curves, which circumvent the non-uniqueness issues in trend matching of type-curves. We use numerical simulations based on finite-elements to verify the accuracy of the proposed solution, and compare it with existing analytical solutions from the literature. Based on the proposed semi-analytical solution, we propose new dimensionless groups and generate type-curves to describe the dimensionless mud-loss volume versus the dimensionless time. To address the non-uniqueness matching issue, we propose, for the first time, complimentary derivative-based type-curves. Both type-curve sets are used in a dual trend matching, which significantly reduced the non-uniqueness issue that is typically encountered in type-curves. We use data for lost circulation from a field case to show the applicability of the proposed method. We apply the semi-analytical solver, combined with Monte-Carlo simulations, to perform a sensitivity study to assess the uncertainty of various fluid and subsurface parameters, including the hydraulic property of the fracture and the probabilistic prediction of the rate of mud leakage into the formation. The proposed approach is based on a novel semi-analytical solution and type-curves to model the flow behavior of Herschel-Bulkley fluids into fractured reservoirs, which can be used as a quick diagnostic tool to evaluate lost-circulation in drilling operations.
Environmental Control of Inter-annual Variability of Net Ecosystem Exchange in Rice-rice Cropping System
Authors: Swain Chinmaya Kumar , Nayak Amaresh Kumar , Chatterjee Dibyendu , Pattanaik Suchismita , Bhattacharyya Pratap , Shanmugam Vijayakumar , Tripathi Rahul , Chatterjee Sumanta , Shahid Mohammad , Pradhan Abhijit , Mohapatra Kiran Kumar , Singh Nihar Ranjan 
Published: December 2021

Abstract
Consecutive five-year long eddy covariance measurements in a lowland tropical rice-rice system were used to investigate the impacts of gross primary productivity (GPP), climate drivers and ecosystem responses (i.e. ecosystem respiration, RE) on the inter-annual variability (IAV) of the net ecosystem exchange (NEE), which is directly related to the agricultural productivity and climate change. The IAV of carbon dioxide fluxes in two crop growing phases i.e. dry and wet season along with fallow period were analysed. The respiratory fluxes build up during the non-growing season were lower by net uptake in growing season. Annual cumulative value of NEE was negative (sink) in both the crop growing season. The variability of climate drivers and changes in the ecosystem responses to drivers revealed a large intra-annual as well as inter-annual variability of net ecosystem fluxes. NEE was found to be strongly correlated with GPP and RE and also with other metrological variables such as photosynthetically active radiation (PAR), precipitation, air temperature and soil temperature. The anomalies of NEE, GPP and RE were observed to be less in 2017 and 2018 which may be due to lower temperature anomalies recorded in these years. Further understanding of biological mechanisms is needed which is involved in the variation of climatological variables to improve our ability to predict future IAV of NEE.
U(VI) Adsorption onto Low Dose Radiation Acclimated Tradescantia Fluminensis
Authors: Liu Jun , Shu Junxiang , Shi Shilong , Li Chao , Li Bing , Liang Dabiao , Li Fei , Lan Tu , Liao Jiali , Liu Ning , Zhang Kunming 
Published: December 2021

Abstract
The plants that long-term grown in radiation area could be acclimated by low dose radiation (LDR). In this paper, LDR acclimated Tradescantia fluminensis (Commelinaceae) was first collected as a biomass adsorbent towards uranium adsorption. Comparative experiments verified the potential radiation effects of LDR acclimation, moreover, qe values of the wild and LDR acclimated Tradescantia fluminensis were ~16 mg/g and 20 mg/g, respectively. U(VI) adsorption amount gradually reached equilibrium after 180 min shaking, and the adsorption process described well by the pseudo-second-order model. However, ionic strength has no obvious effect on the qe values. SEM and TG-DSC suggested good structural stability of LDR acclimated Tradescantia fluminensis during the U(VI) adsorption process. FTIR and XPS verfied the surface coordination of U(VI) via -OH and -COOH groups on LDR acclimated Tradescantia fluminensis surface, and the increasing amounts of the two groups could account for the improved U(VI) adsorption capacity compared to the wild Tradescantia fluminensis. Our present work can indicate that LDR acclimation could be a novel way to obtain biomass adsorbents for U(VI) removal from aqueous solutions.
Determination of the Effect of Magnesium Oxide Nanoparticles (MgO-NP) on in Vitro Culture of Cowpea (Vigna Unguiculata L. Walp)
Authors: KOÇAK Rabia , OKCU Melih , Haliloglu Kamil , Alayli Azize , Nadaroglu Hayrunnisa 
Published: December 2021

Abstract
This study was carried out to determine the effect of different doses of MgO nanoparticles (MgO-NP's) on in vitro regeneration of cowpea. MgO NPs used in the study were synthesized using walnut shell extract by green synthesis method. MgO nanoparticles with 35-40 nm size were used in this research. In the study, the effect of different doses of MgO NP applied to cowpea plant on all in vitro parameters was found to be significant. Considering the parameters examined, the best results in morphogenesis were 185 mg/L, 370 mg/L and 555 mg/L MgO-NPs applications, the highest shoot formation rate was obtained 82.50% with 555 mg/L(MgO-NPs) and 72.50% with 370 mg/L (MgO-NPs). The highest mean values of shoot number, shoot number per explant and shoot length were observed in the application of 370 mg/L MgO-NPs with 61.25, 17.50, and 2.075 (unit) respectively. The best root formation rate was obtained from control and 370 mg/L MgO application at a rate of 27.50%. The highest values were 6.75 (pieces) and 370 mg/L MgO-NPs in the number of roots per explant, 555 mg/L MgO-NPs with 10% in callus formation, and 1.575 (cm) and 370 mg/L MgO-NPs in root length. When all the examined parameters were evaluated, it was determined that the application of 370 mg/L MgO-NPs gave the best results in terms of in vitro parameters.
Terahertz-Wave-Plethysmography (TPG): A New Principle of Radar Based Pulse Detection
Authors: Rong Yu , Theofanopoulos Panagiotis C. , Trichopoulos Georgios C. , Bliss Daniel W. 
Published: December 2021

Abstract
This study presents findings at Terahertz (THz) frequency band for non-contact cardiac sensing application. For the first time, cardiac pulse information is simultaneously extracted using THz waves based on the two established principles in electronics and optics. The first fundamental principle is micro-Doppler (mD) motion effect, initially introduced in coherent laser radar system 1, 2 and first experimentally demonstrated for vital sign detection 3. This motion based method, primarily using coherent phase information from the radar receiver, has been widely exploited in microwave frequency bands and has recently found popularity in millimeter waves (mmWave). The second fundamental principle is reflectance based optical measurement using infrared or visible light. The variation in the light reflection is proportional to the volumetric change of the heart, often referred as photoplethysmography (PPG). PPG has been a popular technology for pulse diagnosis. Recently it has been widely incorporated into various smart wearables for long-term monitoring, such fitness training and sleep monitoring. Herein, the concept of Terahertz-Wave-Plethysmography (TPG) is introduced, which detects blood volume changes in the upper dermis tissue layer by measuring the reflectance of THz waves, similar to the existing remote PPG (rPPG) principle 4. The TPG principle is justified by scientific deduction, electromagnetic wave (EM) simulations and carefully designed experimental demonstrations. Additionally, pulse measurements from various peripheral body parts of interest (BOI), palm, inner elbow, temple, fingertip and forehead, are demonstrated using a wideband THz sensing system developed by Terahertz Electronics Lab at Arizona State University (ASU), Tempe. Among the BOIs under test, it is found that the measurements from forehead BOI gives the best accuracy with mean heart rate (HR) estimation error 1.51 beats per minute (BPM) and stand deviation (std) 1.08 BPM. The results validate the feasibility of radar based plethysmography for direct pulse monitoring. Finally, a comparative study on pulse sensitivity in TPG and rPPG is conducted. The results indicate that the TPG contains more pulsatile from the forehead BOI than that in the rPPG signals and thus generate better heart rate (HR) estimation statistic in the form of empirical cumulative distribution function (CDF) of HR estimation error.
Spectrally Extended Line Field Optical Coherence Tomography Angiography
Authors: Chen Si , Lin Kan , Liu Linbo 
Published: December 2021

Abstract
The widespread usage of optical coherence tomography angiography (OCTA) is hindered by technical gaps including limited field of view (FOV), lack of quantitative flow information, and suboptimal motion correction. We introduce spectrally extended line field (SELF) OCTA that provides advanced solutions to these challenges. SELF-OCTA breaks the speed limitation and achieves two-fold gain in FOV without sacrificing microvascular details and signal strength through parallel imaging. It also relieves the requirement for shorter exposure time in wide-field applications, so that sufficient sensitivity to slow flow is maintained, particularly in spectral-domain OCT. Towards quantitative angiography, the ‘frequency flow’ mechanism overcomes the speed bottleneck by obviating the requirement for superfluous B-scans. In addition, this mechanism facilitates OCTA-data based motion tracking. Since it can be implemented in existing OCT devices without significant hardware modification or affecting existing functions, SELF-OCTA will make non-invasive, wide-field, quantitative, and low-cost angiographic imaging available to larger patient populations.
Highly Sensitive Near-Infrared SERS Nanoprobes for in Vivo Imaging Using Gold-Assembled Silica Nanoparticles with Controllable Nanogaps
Authors: Bock Sungje , Choi Yun-Sik , Kim Minhee , Yun Yewon , Pham Xuan-Hung , Kim Jaehi , Seong Bomi , Kim Wooyeon , Jo Ahla , Ham Kyeong-Min , Lee Sung Gun , Lee Sang Hun , Kang Homan , Choi Hak Soo , Jeong Dae Hong , Chang Hyejin , Kim Dong-Eun , Jun Bong-Hyun 
Published: December 2021

Abstract
Backgroud:
Surface-enhanced Raman scattering (SERS) imaging is widely exploited, given its advantages such as multiplex capacity, non-photobleaching property, and high sensitivity. Near-infrared (NIR) radiation is suitable for in vivo studies because it exhibits good tissue penetration capability.
Results
In this study, gold (Au)-assembled silica (SiO2) nanoparticles (SiO2@Au@Au NPs) as NIR SERS nanoprobes are synthesized by a seed-mediated growth method. SiO2@Au@Au NPs with six different sizes of Au NPs are prepared by controlling the concentration of the Au precursor in the growth step. Therefore, the surface plasmonic band of the nanogaps between Au NPs on the SiO2 surface could be controlled from 4.16 to 0.98 nm, thus generating SERS hotspots. SiO2@Au@Au NPs with a 0.98-nm gap shows high SERS signals after being subjected to an excitation wavelength of 785 nm (enhancement factor ~3.8 × 106). SiO2@Au@Au nanoprobes shows detectable in vivo SERS signals at a concentration of 16 µg/mL in a 7-mm-thick animal tissue specimen. SiO2@Au@Au NPs with 14 different Raman label compounds shows distinguishable SERS signals upon being subcutaneously injected into nude mice.
Conclusion
Through this study, it is highlighted that their potential for use in in vivo applications as multiplex nanoprobes.
Risk Factors and Clinical Outcome in Hemorrhagic Intracranial Dural Arteriovenous Fistulas After Endovascular Treatment
Authors: Wan Chih-Cheng , Lee Chung-Wei , Lin Yen-Heng , Liu Hon-Man 
Published: December 2021

Abstract
Purpose The purpose of this study was to analyze the risk factors of hemorrhage in DAVFs and the factors that influence the clinical outcome of hemorrhagic intracranial DAVFs after endovascular treatment. Methods We reviewed the records of patients with hemorrhagic intracranial DAVFs who received endovascular embolization from December 1996 to April 2015. We analyzed the risk factors of hemorrhage and emphasized the drainage pattern and the classification of drainage location. We also analyzed the factors that influence clinical outcomes such as the patient's age and the time interval between hemorrhage and treatment.Results A total of 32 patients were included in this study. Twenty-seven (84.4%) had engorged medullary veins (EMVs), and 24 (75%) of the hemorrhagic DAVFs had dorsal epidural drainage. Twenty-five (78.1%) had complete occlusion on post-procedural angiography. A significant difference (p=0.0054) of the modified Rankin Scale after treatments between the groups who received treatment within or exceeding 14 days after diagnosis. Conclusions Regional EMVs and dorsal epidural drainage patterns are risk factors in the prediction of hemorrhage in intracranial DAVFs. Patients who received early treatment within 14 days after hemorrhage could have a better clinical outcome.
Combination Therapy of Donepezil and Environmental Enrichment on Memory Deficits in Amyloid-Beta-Induced Alzheimer's Disease Rats
Authors: Gholami Jamileh , Negah Sajad Sahab , Rajabian Arezoo , Hajali Vahid 
Published: December 2021

Abstract
Alzheimer's disease (AD) is progressive neurodegeneration known as the most common cause of dementia, and it is the sixth leading cause of death in older people. Given the promising data on the additive effect of combination therapy with donepezil (Aricept), an acetylcholinesterase inhibitor (AChEI), and regarding the similar neuronal mechanisms through them donepezil and environmental enrichment (EE) exert their enhancing effects on cognition; we asked whether simultaneous treatment with two paradigms in amyloid-beta-induced AD rats may lead to greater cognitive improvements than either treatment individually. AD was induced by intrahippocampal injection of amyloid-beta (1-42, 6 µg), and donepezil was orally administrated (4 mg/kg) for 21 days. Environmental enrichment consisted of housing animals in large cages (50× 50× 50 cm) containing a running wheel and differently shaped objects for 21 days. Spatial learning and memory were assessed in the Morris water maze (MWM) and Real-time PCR was performed to assess the expression of brain-derived neurotrophic factor (BDNF) and M1 muscarinic acetylcholine receptor (AchM1R) within the hippocampus. Spatial memory was impaired in AD animals, and while neither pretreatment with donepezil nor EE alone could significantly restore spatial memory scores in AD rats, combination therapy was effective. BDNF expression was suppressed in AD rats and pretreatment with donepezil plus EE could increase it to the saline levels. The data suggest that a cholinesterase inhibitor and cognitive stimulation can be used effectively in combination to improve cognitive loss in an AD rat model.
Chronic Hepatitis B Viral Activity As A Prognostic Factor For Survival In Malignant Lymphoma
Authors: Seo Kwang Il , Jo Jae-Cheol , Kim Da Jung , Jeong Jee-Yeong , Lee Sangjin , Lee Ho Sup 
Published: December 2021

Abstract
Background: Hepatitis B virus (HBV) infection carries a risk of liver cancer and extrahepatic malignancy. However, the incidence trend and clinical course of malignant lymphoma (ML) in HBV patients are not well known. Methods: Data about ML newly diagnosed in chronic hepatitis B (CHB) patients from 2003 to 2016 were collected from National Health Insurance Service claims. Results: A total of 13,942 CHB patients were newly diagnosed with ML from 2003 to 2016. The number of patients increased 3.8 times, from 442 in 2003 to 1,711 in 2016. The 2-year survival rate of all patients was 76.8%, and the 5-year survival rate was 69.8%. The survival rate of patients taking antivirals due to high viral activity before their diagnosis with ML was significantly lower than that of patients with lower viral activity (1 yr-77.3%, 3 yr-64.5%, and 5 yr-58.3% vs. 1 yr-84.0%, 3 yr-73.4%, and 5 yr-68.0%, respectively). The survival rate of patients with liver cirrhosis (LC) at baseline was significantly lower than that of those without LC. Cirrhotic patients taking antivirals before ML diagnosis had a worse prognosis than who did not. Conclusions: High viral activity in CHB patients with ML is useful in predicting the prognosis for survival.