bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Physical Aging on the Mechanical Properties of Raw, Treated and Compatibilized Coir Fibers-Based Polyisoprene Bio-Composites
Authors: Kakou C. A. , Raji M. , Abdellaoui H. , Bouhfid R. , Qaiss A. , Rodrigue D. 
Published: February 2021

Abstract
The production of bio-composites based on vulcanized rubber reinforced by natural fibers has been widely studied. However, the aging phenomenon occurring during the long-term storage generating irreversible damage is limiting the performance of this kind of composites which has not been studied in details. So the objective of this work was to characterize and understand the structure-mechanical property relationships in these bio-composites and to correlate the effective crosslinking density with physical aging as a function of fiber content (0, 20, 30 and 40 wt.%) and fiber surface modification (alkali treatment) for the system polyisoprene (PI) and coir fibers. Furthermore, interfacial adhesion was improved by using maleic anhydride grafted polyisoprene as a coupling agent. From the samples produced, a complete set of morphological (scanning electron microscopy) and mechanical (shear and tension) characterization was performed before and after natural aging. The results showed that the tensile modulus increased with fiber content for the range of conditions studied and the presence of a coupling agent always gave higher tensile strength due to better interfacial stress transfer. However, important elasticity loss (strain at break) was observed due to the low fiber elasticity. Finally, different physical aging mechanisms led to changes in the molecular configuration and a reduction of free volume caused by a post-curing phenomenon of the polyisoprene matrix and low environmental stability of the fibers. These phenomena were shown to increase the Young’s modulus of the neat matrix by eight times compared to the unaged neat polyisoprene, but a smaller variation (five times) was observed for the bio-composites which was related to different crosslinking density and coir fibers state of dispersion in the vulcanized matrix
Preparation and Characterization of Reduced Graphene Oxide Based Natural Rubber Nanocomposites
Authors: Shahamatifard F. , Rodrigue D. , Park K. , Frikha S. , Mighri F. 
Published: February 2021

Abstract
This work describes the effect of reduced graphene oxide (RGO) addition in natural rubber (NR). Firstly, RGO was synthesized based on the improved Hummer’s method then characterized by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA) to confirm that the RGO surface contains hydroxyl, epoxy, and carboxyl functional groups to improve graphene interaction with the NR matrix. In a second step, the synthesized RGO was predispersed in NR latex using the co-coagulation technique then added at different amounts (0 to 2 parts per hundred rubber (phr)) to a basic NR formulation and compounded in an internal mixer. The results show that the crosslink density of the developed NR/RGO nanocomposites increased by 65% for RGO concentration of 2.0 phr. For the same RGO concentration, a significant increase in tensile strength (53%) and Young’s modulus (31%) were also observed. Finally, a significant improvement (26%) of the thermal conductivity was obtained with the addition of only 0.5 phr of RGO.
The expression of modality in Logoori
Authors: Gluckman John , Bowler Margit 
Published: February 2021

AbstractThis study presents a theoretically informed description of the expression of modality in Logoori (Luyia; Bantu). We document verbal and non-verbal modal expressions in Logoori, and show how these expressions fit into proposed typologies of modal systems (Kratzer, Angelika. 1981. The notional category of modality. In Hans-Jurgen Eikmeyer & Hannes Rieser (eds.),Words, worlds, and contexts: New approaches in word semantics, 38–74. Berlin: Mouton de Gruyter, Kratzer, Angelika. 1991. Modality. In Armin von Stechow & Dieter Wunderlich (eds.),Semantics: An international handbook of contemporary research, 639–650. Berlin: Mouton de Gruyter; van der Auwera, Johan & Vladimir Plungian. 1998. Modality’s semantic map.Linguistic Typology2. 79–124.https://doi.org/10.1515/lity.1998.2.1.79; Nauze, Fabrice. 2008.Modality in typological perspective. Amsterdam: Institute for Logic, Language, and Computation PhD thesis). We show that Logoori’s modal system raises some interesting questions regarding the typology and theoretical analysis of modality and its relationship to other kinds of meaning. Our study contributes to the nascent but growing research on modal systems cross linguistically by adding data from an understudied Bantu language.
The utility of next-generation sequencing technologies in diagnosis of Mendelian mitochondrial diseases and reflections on clinical spectrum
Authors: Kose Melis , Isik Esra , Aykut Ayça , Durmaz Asude , Kose Engin , Ersoy Melike , Diniz Gulden , Adebali Ogun , Ünalp Aycan , Yilmaz Ünsal , Karaoğlu Pakize , Edizer Selvinaz , Tekin Hande Gazeteci , Özdemir Taha Reşid , Atik Tahir , Onay Hüseyin , Özkınay Ferda 
Published: February 2021

Abstract

Objectives
Diagnostic process of mitochondrial disorders (MD) is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next-Generation Sequencing (NGS) technology offers a high-throughput platform for nuclear MD.

Methods
We included 59 of 72 patients that undergone WES and targeted exome sequencing panel suspected to have potential PMDs. Patients who were included in the analysis considering the possible PMD were reviewed retrospectively and scored according to the Mitochondrial Disease Criteria Scale.

Results
Sixty-one percent of the patients were diagnosed with whole-exome sequencing (WES) (36/59) and 15% with targeted exome sequencing (TES) (9/59). Patients with MD-related gene defects were included in the mito group, patients without MD-related gene defects were included in the nonmito group, and patients in whom no etiological cause could be identified were included in the unknown etiology group. In 11 out of 36 patients diagnosed with WES, a TES panel was applied prior to WES. In 47 probands in 39 genes (SURF1, SDHAF1, MTO1, FBXL4, SLC25A12, GLRX5, C19oRF12, NDUFAF6, DARS2, BOLA3, SLC19A3, SCO1, HIBCH, PDHA1, PDHAX, PC, ETFA, TRMU, TUFM, NDUFS6, WWOX, UBCD TREX1, ATL1, VAC14, GFAP, PLA2G6, TPRKB, ATP8A2, PEX13, IGHMBP2, LAMB2, LPIN1, GFPT1, CLN5, DOLK) (20 mito group, 19 nonmito group) 59 variants (31 mito group, 18 nonmito group) were detected. Seven novel variants in the mito group (SLC25A12, GLRX5, DARS2, SCO1, PC, ETFA, NDUFS6), nine novel variants in the nonmito group (IVD, GCDH, COG4, VAC14, GFAP, PLA2G6, ATP8A2, PEX13, LPIN1) were detected.

Conclusions
We explored the feasibility of identifying pathogenic alleles using WES and TES in MD. Our results show that WES is the primary method of choice in the diagnosis of MD until at least all genes responsible for PMD are found and are highly effective in facilitating the diagnosis process.
Daily monitoring of vaginal interleukin 6 as a predictor of intraamniotic inflammation after preterm premature rupture of membranes – a new method of sampling studied in a prospective multicenter trial
Authors: Seliger Gregor , Bergner Michael , Haase Roland , Stepan Holger , Schleußner Ekkehard , Zöllkau Janine , Seeger Sven , Kraus Frank Bernhard , Hiller Grit Gesine Ruth , Wienke Andreas , Tchirikov Michael 
Published: February 2021

Abstract

Objectives
(A) To introduce a new technique for vaginal fluid sampling (biocompatible synthetic fiber sponge) and (B) evaluate the collected vaginal fluid interleukine-6 (IL-6vag)-concentration as a new diagnostic tool for daily monitoring of intrauterine inflammation after preterm premature rupture of membranes (PPROM). Secondary objectives were to compare the potential to predict an intrauterine inflammation with established inflammation parameters (e.g., maternal white blood cell count).

Methods
This prospective clinical case-control diagnostic accuracy multicenter study was performed with women after PPROM (gestational age 24.0/7 – 34.0/7 weeks). Sampling of vaginal fluid was performed once daily. IL-6vag was determined by electrochemiluminescence-immunoassay-kit. Neonatal outcome and placental histology results were used to retrospectively allocate the cohort into two subgroups: 1) inflammation and 2) no inflammation (controls).

Results
A total of 37 cases were included in the final analysis. (A): Measurement of IL-6 was successful in 86% of 172 vaginal fluid samples. (B): Median concentration of IL-6vag in the last vaginal fluid sample before delivery was significantly higher within the inflammation group (17,085 pg/mL) compared to the controls (1,888 pg/mL; p=0.01). By Youden’s index an optimal cut-off for prediction an intrauterine inflammation was: 6,417 pg/mL. Two days before delivery, in contrast to all other parameters IL-6vag remained the only parameter with a sufficient AUC of 0.877, p<0.001, 95%CI [0.670–1.000].

Conclusions
This study established a new technique for vaginal fluid sampling, which permits assessment of IL-6vag concentration noninvasively in clinical daily routine monitoring.
Delivery characteristics in pregnancies with stillbirth: a retrospective case-control study from a tertiary teaching hospital
Authors: Pekkola Maria , Tikkanen Minna , Gissler Mika , Loukovaara Mikko , Paavonen Jorma , Stefanovic Vedran 
Published: February 2021

Abstract

Objectives
We compared delivery characteristics and outcome of women with stillbirth to those with live birth.

Methods
This was a retrospective case-control study from Helsinki University Hospital, Finland. The study population comprised 214 antepartum singleton stillbirths during 2003–2015. Two age-adjusted controls giving live birth in the same year at the same institution were chosen for each case from the Finnish Medical Birth Register. Delivery characteristics and adverse pregnancy outcomes were compared between the cases and controls, adjusted for gestational age.

Results
Labor induction was more common (86.0 vs. 22.0%, p<0.001, gestational age adjusted odds ratio [aOR] 35.25, 95% confidence interval [CI] 12.37–100.45) and cesarean sections less frequent (9.3 vs. 28.7%, p<0.001, aOR 0.21, 95% CI 0.10–0.47) among women with stillbirth. Duration of labor was significantly shorter among the cases (first stage 240.0 min [115.0–365.0 min] vs. 412.5 min [251.0–574.0 min], p<0.001; second stage 8.0 min [0.0–16.0 min] vs. 15.0 min [4.0–26.0 min], p<0.001). Placental abruption was more common in pregnancies with stillbirth (15.0 vs. 0.9%, p<0.001, aOR 8.52, 95% CI 2.51–28.94) and blood transfusion was needed more often (10.7 vs. 4.4%, p=0.002, aOR 6.5, 95% CI 2.10–20.13). The rates of serious maternal complications were low.

Conclusions
Most women with stillbirth delivered vaginally without obstetric complications. The duration of labor was shorter in pregnancies with stillbirth but the risk for postpartum interventions and bleeding complications was higher compared to those with live birth.
Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak
Authors: Häusler Sebastian , Weigl Marco , Ambrosch Andreas , Gruber Rudolf , Seelbach-Göbel Birgit , Fill Malfertheiner Sara 
Published: February 2021

Abstract

Objectives
The Severe Acute Respiratory Distress Corona Virus 2 (SARS-CoV-2) pandemic poses special challenges for the society and especially the medical staff. Even if a rather mild course is assumed among pregnant women the measures to prevent transmission of the infection are of outstanding importance.

Methods
To screen asymptomatic pregnant women during admission to our university maternal hospital we focused on anti-SARS-CoV-2-specific IgG and IgA antibody responses. Hundred and fifty one women admitted to the hospital for childbirth or caesarean delivery were included. In case of suspicious anti-SARS-CoV-2-antibody levels an RT-PCR was performed to confirm an ongoing infection with SARS-CoV-2.

Results
A total of 89% showed negative results for anti-SARS-CoV-2-IgA antibodies, whereas 3% were borderline and 7% positive (both labeled as suspicious). In only one patient with suspicious serology we detected SARS-CoV-2-RNA in the following RT-PCR. 2% presented anti-SARS-CoV-2-IgG antibodies, all being positive for anti-SARS-CoV-2-IgA. The observed positive rate of our study collective of 10.6% seemed much higher than the expected one (1.3%) based on the reports of the Robert Koch Institute and the specifications given by the test’s manufacturer. The expected positive predictive value (PPV) was 4.3–6.7 times higher than the observed one.

Conclusions
To our knowledge this is the first report of anti-SARS-CoV-2-antibody levels in the peripartum period of asymptomatic women. As the positive anti-SARS-CoV-2 serology poorly correlated with the confirmatory RT-PCR and the fact that mainly the detection of the virus by PCR correlates with the patient’s infectiousness we suggest to rather perform a SARS-CoV-2-PCR-based admission screening in perinatal centers to prevent the spread of the disease.
„Mein Bestreben, das Martyrium zu verherrlichen…“ Zur Idee des Martyriums in Kierkegaards Journalen ab 1846
Authors: Winter Roman 
Published: February 2021

Abstract
The article aims at analysing a long and unduly neglected concept in Kierkegaard’s thought: the concept of martyrdom. I argue that this is indeed of central concern for Kierkegaard, and, moreover, that he conceptualizes it in a semantically unified and consistent way. In order to prove this I will focus on the so-called NB journals and provide a comprehensive account of the terms martyrdom and martyr in the context of these sources. Upon closer scrutiny, Kierkegaard distinguishes between two basic types of martyrdom: immediate and reflective. All other forms, as they appear in the journals (and also in the pseudonymous authorship), can be traced back to these basic types.
The Faust Project in Kierkegaard’s Early Journals
Authors: Bravo Nassim 
Published: February 2021

Abstract
This article offers a detailed and compact account of what might be called Kierkegaard’s Faust project, that is, the collection of notes, bibliographies and reflections on the mythical German necromancer that the young Kierkegaard registered in his various journals and notebooks from the years 1835 – 1837. As is well known, the young writer presumably intended to pen a book or essay about the universal idea represented by Faust. Additionally, I discuss Kierkegaard’s project within the context of the 1830s, the reception of the Faustian myth among his Danish contemporaries such as J.L. Heiberg and H.L. Martensen, and the enthusiasm for Goethe that seized Copenhagen during those years.
Effect of cooling rates of solution treatment on rejuvenation heat-treated microstructures of a cast nickel-based superalloy
Authors: Paa-rai Chuleeporn , Lothongkum Gobboon , Wangyao Panyawat 
Published: February 2021

Abstract
IN-738 turbine blade samples, deteriorated after long term service at high temperatures, were solution heat-treated at two temperatures, 1398 K and 1473 K, for 7.2 ks. Subsequently, the samples were cooled down in different atmospheres, in air and in furnace, for the purpose of studying the effects of different cooling media (rates) on the restored microstructures. Following this, the samples were aged at 1118 K for 43.2 ks and 86.4 ks in order to determine the characteristic of re-precipitated gamma prime particles. A scanning electron microscope (SEM) and ImageJ analysis software were used. The results show that the cooling in air provided gamma prime particles re-precipitating in spherical shape while the cooling in a furnace resulted in coarse gamma prime particles re-precipitating in irregular shape. The samples solutionized at 1398 K for 7.2 ks cooled down in air and then aging at 1118 K provided bimodal microstructure, while the sample solutionized at 1473 K for 7.2 ks, followed by air cooling and aging at 1118 K generated unimodal γ’ precipitation in spherical shape. Cooling in a furnace provides coarse γ’ recipitated particles in more irregular shape for the both solutionizing temperatures studied here. Cooling in a furnace provides coarse γ’ precipitated particles in more irregular shape for the both solutionizing temperatures studied here.
Ultrasonic C-scan techniques for the evaluation of impact damage in CFRP
Authors: Santos Mário , Santos Jaime , Reis Paulo , Amaro Ana 
Published: February 2021

Abstract
In the present work, different ultrasonic C-scan approaches were used to evaluate Carbon Fiber Reinforced Polymers (CFRP) submitted to impacts of low energy, in order to evaluate their effectiveness for the detection and characterization of small defects. In particular, as to the question how useful could be the air-coupled C-scan approach, using low frequencies, for in-service application. For that goal, several samples with different stacking sequences and thicknesses were impacted with 1.5 and 3 J. Then, ultrasonic C-scan images were produced by immersion pulse-echo (in amplitude and time-of-flight (TOF)) and immersion through-transmission, and also by air-coupling through-transmission. The immersion C-scan images were produced using 5, 10 and 20 MHz probes and the air-coupled C-scan was made using two 400 kHz probes. The obtained images for the considered samples show that all used methods are able to detect the defects and give acceptable information about their size and shape. However, if the way of delamination evolving over thickness is of interest, the images by TOF should be used. As expected, good image resolution with sharp contour defects require high frequencies. Nevertheless, the air-coupled C-scan demonstrated similar capabilities to detect defects, with the advantage that the coupling medium is air, thus widening the range of applications, such as real-time damage monitoring of composite structures. As a disadvantage, the air C-scan system requires high power emission signals, and also great amplification of the received signals, to face the considerable attenuation in the air.
Strength of double-reinforced adhesive joints
Authors: Adin Mehmet Şükrü , Kılıçkap Erol 
Published: February 2021

Abstract
The use of adhesive joints is increasing in aerospace, aviation, automotive, construction and marine industry due to their easily applicable properties, low-costs and light weights compared to traditional jointing methods such as bolts, rivets, welding and soldering. Due to the high fatigue strength, resistance to seawater corrosion and light weight, aluminum alloys, with their high satiety, fracture strength, light weight, high specific strength and good dimensional stability and other properties, glass fiber reinforced composite materials have widespread uses.
Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury
Authors: Pelisch Nicolas , Rosas Almanza Jose , Stehlik Kyle E. , Aperi Brandy V. , Kroner Antje 
Published: February 2021

AbstractSecondary damage after spinal cord injury (SCI) occurs because of a sequence of events after the initial injury, including exacerbated inflammation that contributes to increased lesion size and poor locomotor recovery. Thus, mitigating secondary damage is critical to preserve neural tissue and improve neurologic outcome. In this work, we examined the therapeutic potential of a novel antisense oligonucleotide (ASO) with special chemical modifications [2′-deoxy-2-fluoro-D-arabinonucleic acid (FANA) ASO] for specifically inhibiting an inflammatory molecule in the injured spinal cord. The chemokine CCL3 plays a complex role in the activation and attraction of immune cells and is upregulated in the injured tissue after SCI. We used specific FANA ASO to inhibit CCL3 in a contusive mouse model of murine SCI. Our results show that self-delivering FANA ASO molecules targeting the chemokine CCL3 penetrate the spinal cord lesion site and suppress the expression of CCL3 transcripts. Furthermore, they reduce other proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-1β after SCI. In summary, we demonstrate for the first time the potential of FANA ASO molecules to penetrate the spinal cord lesion site to specifically inhibit CCL3, reducing proinflammatory cytokines and improve functional recovery after SCI. This novel approach may be used in new treatment strategies for SCI and other pathologic conditions of the CNS.
Otoacoustic Emissions Evoked by the Time-Varying Harmonic Structure of Speech
Authors: Saiz-Alía Marina , Miller Peter , Reichenbach Tobias 
Published: February 2021

AbstractThe human auditory system is exceptional at comprehending an individual speaker even in complex acoustic environments. Because the inner ear, or cochlea, possesses an active mechanism that can be controlled by subsequent neural processing centers through descending nerve fibers, it may already contribute to speech processing. The cochlear activity can be assessed by recording otoacoustic emissions (OAEs), but employing these emissions to assess speech processing in the cochlea is obstructed by the complexity of natural speech. Here, we develop a novel methodology to measure OAEs that are related to the time-varying harmonic structure of speech [speech-distortion-product OAEs (DPOAEs)]. We then employ the method to investigate the effect of selective attention on the speech-DPOAEs. We provide tentative evidence that the speech-DPOAEs are larger when the corresponding speech signal is attended than when it is ignored. Our development of speech-DPOAEs opens up a path to further investigations of the contribution of the cochlea to the processing of complex real-world signals.
The Neuroscience Community Has a Role in Environmental Conservation
Authors: Keifer Joyce , Summers Cliff H. 
Published: February 2021

AbstractWe previously argued that the neuroscience community has a role in environmental conservation because protection of biodiversity and the specialized behavioral adaptions of animals is essential to understanding brain structure and function. Preserving biodiversity and the natural world is also linked to human mental health and broadens our insight on the origins of psychiatric disorders like stress, anxiety, and depression. The study of neuroscience has become a global scientific pursuit that involves thousands of researchers and has an economic impact in the billions of dollars. As a group of biomedical research scientists, neuroscientists have the knowledge base and public credibility to convincingly promote sustainable environmental actions and policies. Here, we outline several key areas in which we as a neuroscience academic community can participate to preserve a rich global biodiversity and confront the environmental crises that lie before us.