bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Statin Intensity on the Progression of Cardiac Allograft Vasculopathy
Authors: Ellimuttil Tracey M , Harrison Kimberly , Rollins Allman T , Feurer Irene D , Rega Scott A , Gray Jennifer , Menachem Jonathan N 
Published: November 2021

Background: In the non-transplant population, hyperlipidaemia has shifted from targeting LDL goals to statin intensity-based treatment. It is unknown whether this strategy is also beneficial in cardiac transplantation. Methods: This single-centre retrospective study evaluated the effect of statin use and intensity on time to cardiac allograft vasculopathy (CAV) after cardiac transplantation. Kaplan–Meier and Cox proportional hazards regression survival methods were used to assess the association of statin intensity and median post-transplant LDL on CAV-free survival. Results: The study involved 143 adults (71% men, average follow-up of 25 ± 14 months) who underwent transplant between 2013 and 2017. Mean CAV-free survival was 47.5 months (95% CI [43.1–51.8]), with 29 patients having CAV grade 1 or greater. Median LDL was not associated with time to CAV (p=0.790). CAV-free survival did not differ between intensity groups (p=0.435). Conclusion: Given the non-statistically significant difference in time to CAV with higher intensity statins, the data suggest that advancing moderate- or high-intensity statin after cardiac transplantation may not provide additional long-term clinical benefit. Trial registration: Not applicable.
New way of closure of upper jaw defects
Authors: Zaderenko I. A. , Berdigylyjov M.  T. , Orlova I. V. , Segura A. M. , Sekretnaya A. O. , Khromushina A. V. 
Published: November 2021

Article describes new original way of one-stage closure of upper jaw defects by using cutaneous-adiposal flap. The method is patented (patent of the Russian Federation for invention No. 2489096). We propose to use cutaneous-adiposal flap, mobilized in nasolabial furrow area, with axial pattern blood supply from angular artery and vein, by rotating to defect through buccal tonnel. This method allows to reliably eliminate upper jaw defect, improve functional and aesthetic results of treatment with minimal injuries caused by operation.Objective is to introduce new way of closure of upper jaw defects.
Teachers’ autonomous motivation and work engagement: The role of the principal’s democratic leadership style and psychological climate
Authors: Mokretsova L. A. , Sychev O. A. , Bespalov A. M. , Vlasov M. S. , Prudnikova M. M. 
Published: November 2021

Introduction. The dependence of autonomous motivation of teachers on the principal’s leadership style was previously considered on the basis of the concept of transformational leadership by B. Bass, whereas its relationship with the styles described in the concept of K. Levin is understudied. The mediators of relations between leadership styles and teachers’ motivation are not sufficiently studied. According to the self-determination theory, such mediators can include psychological climate.Aim. The aim of the current research was to develop an integrative concept of leadership styles by K. Lewin and the theory of self-determination by E. Deci and R. Ryan model of dependence of teachers’ professional motivation and work engagement on the principal’s leadership styles. An additional task was to analyse the mediating role of the psychological climate of the school staff.Methodology and research methods. The correlational research was realised with the sample comprising 238 secondary school teachers in Biysk. The participants answered the Professional Motivation Questionnaire, Utrecht Work Engagement Scale, Style of Leadership Questionnaire and Group Atmosphere Scale. During processing of obtained data the authors used correlation analysis, t-tests for comparison of means and structural equation modelling.Results. The elaborated structural model demonstrates that the democratic leadership style of the school principal is positively related to the autonomous motivation of teachers directly and indirectly through the psychological climate. The principal’s liberal leadership style is inversely related to teachers’ work engagement. In terms of self-determination theory, these results reflect different opportunities to meet the basic psychological needs of employees in teams with different psychological climate and principal’s leadership style.Scientific novelty includes elaborated model describing the relationship of principals’ leadership styles according to K. Lewin’s typology with autonomous motivation and work engagement of teachers. The revealed effect of partial mediation of relations between democratic leadership style and autonomous motivation of teachers through psychological climate clarifies the ideas about the system of socio-psychological factors of professional motivation.Practical significance consists in usage of the results for improvement of psychological training of principals, optimisation of their leadership style for creating better psychological atmosphere and support for teachers’ productive motivation.
Terapia fotodynamiczna – znaczenie w onkologii
Authors: Mossakowska Beata , Fabisiewicz Anna , Siedlecki Janusz 
Published: November 2021

Terapia fotodynamiczna (ang. photodynamic therapy, PDT) jest jedną z najmniej toksycznych metod walki z rakiem. Podany pacjentowi fotouczulacz (ang. photosensitizer, PS) akumuluje się w tkance guza, gdzie pod wpływem światła o odpowiedniej długości fali i intensywności dochodzi do jego aktywacji. Aktywowany PS w obecności tlenu prowadzi do powstania reaktywnych form tlenu (ang. reactive oxygen species, ROS), które powodują liczne uszkodzenia. Powstałe nieodwracalne uszkodzenia prowadzą do śmierci komórek poprzez mechanizm apoptozy, nekrozy lub autofagii. Ponadto w wyniku PDT dochodzi do zapoczątkowania ostrej lokalnej reakcji zapalnej, która bierze udział w usuwaniu martwych komórek, przywróceniu normalnej homeostazy tkanek, a czasami i w rozwinięciu odporności ogólnoustrojowej. Jednak część komórek nowotworowych może przeżyć terapię i zmienić swój fenotyp, prowadząc do pojawienia się oporności. W ochronę przed cytotoksycznym efektem PDT mogą być zaangażowane mechanizmy prowadzące do obniżenia poziomu fotouczulacza w komórkach, zwiększone zdolności antyoksydacyjne, nadekspresja białek opiekuńczych czy aktywacja ścieżek sygnałowych sprzyjających przeżyciu.
ESTIMATION OF PERIODONTAL MICROCIRCULATION, JAW AFTER INJECTION OF ANTI-RESORPTIVE DRUG IN EXPERIMENT
Authors: Kosach German , Petrosyan Alexander , Oisieva Karina , Kutukova Svetlana , Zubareva Anna , Chefu Svetlana , YAREMENKO ANDREY , Vlasov Timur 
Published: November 2021

Importance. Determining the influence of different medications in the development of different diseases is a prerequisite for adequate comprehensive treatment of patients. At present, there is insufficient data on the influence of anti-osteoclastic drugs on the microcirculation, which may have an impact.
The aim. To study the effects of the monoclonal antibody denosumab on the development of osteonecrosis of the jaw of rats.
Methodology. The study was carried out on 36 Wistar Line rats in the Department of Pathophysiology with the course of clinical pathophysiology First Pavlov State Medical University. The osteonecrorosis of the jaws of rats was induced by the extracted of a lower first molar. The observation was carried out with diagnostic studies of microcirculation (doppler), bone structure (3D computer tomography of jaws), followed by statistical processing of the data.
Results. It has been shown that the greatest decrease in blood flow rate and the greatest bone defect is determined in the group of rats with the maximum dose of the monoclonal antibody preparation of denosumab by the time of 4 weeks, 0.5 mg/kg intravenous administration. Also, there has been evidence of a difference in blood flow reduction between the histological layers of the lower jaw. Thus, the intrabone blood flow was damaged much more, than the layer of mucous membrane of the gum.
Conclusions. The combined method of dopplerography allows the determination of blood flow status on different histological layers. It is possible to determine the extent to which different pharmacological preparations influence the rate of blood flow in the local area without invasive interventions. The study of monoclonal antibodies is an acute problem in the world of surgical dental practice, which requires further study.
TAʾṮĪR QIRĀʾAH AL-MURABBAʿI FĪ TAʿLĪM AL-QIRĀʾAH
Authors: Ahmad Rusmilawati 
Published: November 2021

Abstract:The aims of this research are: To study how to apply and influence the strategy of square or text cut and Broken Square / Text & Index Card Match for Islamic high school students in Balangan.The research design used in this study was an experimental research design.The results of this study are 1) during the implementation of the Broken Square / Text & Index Card Match strategy, it can be seen that there is a change in the learning patterns of students who answer the questions asked by the researcher, in addition, they are also more enthusiastic and active in working on the assigned task. Poor activity also tends to decrease and 2) the effect on learning outcomes is found by students about Broken Square / Text & Index Card Match at Madrasah Tsanawiyah Negeri 3 Balangan and Madrasah Tsanawiyah Al Hidayah Inan Paringin Selatan according to the test results was 0.00 is smaller than the significance score α = 0.05, this indicates that Ha is accepted and H0 is rejected.
Spline Nonparametric Regression to Analyze Factors Affecting Gender Empowerment Measure (GEM) in East Java
Authors: Mahfiroh Luluk , Farida Yuniar 
Published: November 2021

Gender is a multidimensional issue that's not limited to gender discrimination, but alsoincludes the economic, educational, and health aspects, which then become the focus of almost all the Sustainable Development Goals (SDGs). Evaluation of the development devoted to the perspective of the gender using several indicators, Gender Development Index (GDI) and Gender Empowerment Measure (GEM). GEM describes the role of women in the economic sphere and is measured by equality in political participation. GEM of East Java for 5 consecutive years (2014 – 2018) is lower than the average national GEM. This study aims to identify factors affecting GEM in East Java using nonparametric regression spline quadratic. The result ofthe regression model shows the factors affecting GEM East Java is the Labor Force Participation Rate(LFPR) population of women (), School Participation Rate(SPR) high school population of women (), Percentage of Population Female thatWorking in the formal sector (), sex ratio (), Percentage of Population Female that Working as members of People’s Representative Council (), Percentage of Population Female that working as Civil Servants (), and rate of women's income donations (). The model generates value of 93.74% and MAPE of 3.22%.This research contributes to the implementation of non-parametric spline regression in identifying various factors that influence social phenomena.
Pendampingan Wirausaha Pengrajin Musik Panting P.I.X Musik Kota Banjarmasin di Masa Covid 19
Authors: Najamudin Muhammad , Mahendra Benny 
Published: November 2021

Tujuan kegiatan pengabdian kepada mayarakat ini yaitu: untuk memberikan pemahaman mengenai kewirausahaan pengrajin alat tradisional musik panting (P.I.X) musik Kota Banjarmasin tentang wawasan kewirausahaan, cara mempromosikan dimasa pandemi covid 19, yang dimana penurunan omset pengrajin menurun sejak bulan Februari sampai Juni 2020. Hal ini dikarenakan menurunya produktivitas pertunjukan musik. Kegiatan dilakukan melalui pendampingan wirausaha pengrajin musik panting P.I.X musik di Kota Banjarmasin dari produksi, pemasaran hingga pengurusan hak merek dagang Hak Kekayaan Intelektual (HKI). Metode program pengabdian kepada masyarakat berbasis kemitraan. Bentuk kegiatan pendampingan meliputi tahapan-tahan sebagai berikut; memberikan materi konsep wirausaha, melakukan pendampingan pemanfaatan media promosi dalam pemasaran produk, dan terdaftar di Hak Kekayaan Intelektul (HKI) sebagai merek dagang dengan merek P.I.X musik. Simpulan dalam pengabdian kepada masyarakat ialah proses pendampingan kewirausahaan pengrajin musik panting P.I.X musik berjalan dengan lancar dan meningkat omset penjualannya hingga mendapatkan HKI (Hak Kekayaan Intelektual) merek dagang.The purpose of this community service assistance activity is to understand the entrepreneurship of the PIX music craftsmen in Banjarmasin regarding entrepreneurial insight, how to promote during the Covid 19 pandemic, in which the decline in artisans turnover decreased from February to June 2020. This is due to decreased productivity—music show. The activity's objective is to provide entrepreneurship assistance for P.I.X music artisans in Banjarmasin from production, marketing and IPR. Partnership-based community service program methods. Mentoring activities include the following stages; providing material on entrepreneurial concepts, assisting in promotional media in product marketing, and intellectual property rights (IPR). The conclusion in community service is the process of entrepreneurship assistance for P.I.X music artisans to run smoothly, and their sales turnover increases until they get IPR (Intellectual Property Rights).
Pelatihan Pembuatan Alat Permainan Edukatif Berbasis Pendekatan Saintifik bagi Guru PAUD di Kota Palembang
Authors: Lena Hasmalena , Rukiyah Rukiyah , Syafdaningsih Syafdaningsih , Rantina Mahyumi , Utami Febriyanti , Karnita Anggun , Karnita Anggun , Munawaroh Atthoyibah , Munawaroh Atthoyibah 
Published: November 2021

Alat Peraga/Permainan Edukatif (APE) bagi anak usia dini memegang peranan penting sebagai media stimulasi, pembelajaran dan permainan, sedangkan bagi guru merupakan sarana yang membantu dalam penyampaian pembelajaran. Pelatihan ini bertujuan agar guru PAUD dapat membuat APE serta untuk mengembangkan keterampilan-keterampilan guru dalam membuat inovasi dalam pembuatan APE untuk anak usia dini. Kegiatan ini dilakukan pada hari Sabtu, 8 Agustus 2020 secara online melalui aplikasi Zoom Meeting. Materi yang disampaikan meliputi, (1) Hakikat alat permainan edukatif, (2) Jenis-jenis APE, (3) Keterampilan pembuatan APE, (4) Langkah-langkah pembuatan APE, dan (5) Praktik pembuatan APE dalam proses pembelajaran sesuai karakteristik anak. Kegiatan pelatihan dilaksanakan melalui aplikasi zoom meeting dengan jumlah 36 orang peserta guru PAUD. Model kegiatan yaitu pendampingan dan metode kegiatan yang digunakan presentasi dan peragaan serta unjuk kerja. Berdasarkan hasil evaluasi terjadi peningkatanan pengetahuan guru-guru PAUD setelah pelatihan, hal ini ditunjukkan dengan hasil bahwa guru mampu membuat rancangan alat permainan edukatif, , guru mempu menerapkan alat permainan edukatif walapun dilakukan secara daring dan guru mampu mengimplementasikan kepada anak tentang alat permainan edukatif berbasis pendekatan saintifik. Teaching aids/educational games (APE) for early childhood play an important role as a medium of stimulation, learning and games, while for teachers, it is a tool that helps in learning delivery. This training aims to make PAUD teachers make APE and develop teaching skills in making innovations in making APE for early childhood. This activity was carried out on Saturday, August 8, 2020, online through the Zoom Meeting application. The materials presented include (1) The nature of educational game tools, (2) Types of APE, (3) Skills for making APE, (4) Steps for making APE, and (5) Practice of making APE in the learning process according to children's characteristics. . The training activities were carried out through the Zoom Meeting application with a total of 36 PAUD teacher participants. The activity model is mentoring and activity methods used by presentations and demonstrations as well as performance. Based on the evaluation results, there was an increase in the knowledge of PAUD teachers after training, and this was shown by the results that teachers were able to design educational game tools, teachers were able to apply educational game tools even though they were done online. Teachers were able to implement to children about scientific approach-based educational game tools.
Sosialisasi Mitigasi Bencana Alam Tanah Longsor melalui Konsep Fisika Terpadu di Kecamatan Palolo Kabupaten Sigi
Authors: Hatibe Amiruddin , Muslimin Muslimin , Syarif Muhammad , Haeruddin Haeruddin 
Published: November 2021

Bencana longsor merupakan salah satu peristiwa alam yang paling umum terjadi di Indonesia. Oleh karena itu, perlu adanya penambahan wawasan masyarakat tentang mitigasi bencana alam melalui kegiatan sosialisasi. Tujuan kegiatan pengabdian ini adalah untuk menambah wawasan pengetahuan fisika, teknik peringatan dini, dan mengenalkan faktor-faktor pendorong dan penghambat terjadinya bencana alam pada masyarakat Kecamatan Palolo. Kegiatan ini diikuti oleh 50 orang. Metode yang digunakan adalah sosialisasi bencana alam tanah longsor. Hasil pengabdian ini adalah bertambahnya wawasan pemahaman masyarakat terhadap konsep fisika terpadu terhadap kondisi topografi Kecamatan Palolo, teknik peringatan dini dalam mitigasi terhadap ancaman bencana alam tanah longsor, dan menemukan faktor pendorong berupa sifat gotong royong dalam menangani bencana alam tanah secara tradisional yang sudah tumbuh dalam masyarakat sebagai suatu kearifan lokal dan menjadi perhatian dalam sosialisasi. Berdasarkan kegiatan pengabdian yang telah dilakukan dapat disimpulkan bahwa pentingnya konsep fisika yang sederhana pada masyarakat dalam menangani bencana tanah longsor, diperlukannya peringatan dini yang bersifat mitigasi dari tanda-tanda alam, dan tetap melestarikan kearifan lokal gotong royong untuk menyelesaikan masalah masyarakat desa, serta pentingnya perangkat desa memotivasi masyarakat pada setiap kali kegiatan sosialisasi atau pertemuan desa secara melembaga. Landslides are one of the most common natural events in Indonesia. Therefore it is necessary to increase public knowledge about natural disaster mitigation through socialization activity. This community service aimed to broaden the knowledge of physics, early warning techniques and recognize the driving and inhibiting factors of natural disasters in the people of Palolo Subdistrict. Fifty people attended this community service. The method used was the socialization of landslide natural disasters. The results of this community service were increasing community understanding of integrated physics concept of the topographic conditions of Palolo District, early warning techniques in mitigating the threat of landslides, and finding driving factors in the form of cooperation in dealing with traditional land disasters that have grown in society as local wisdom and concern in socialization. Based on the community service that has been carried out, it can be concluded that the importance of simple physics concepts for the community in dealing with landslide disasters, the need for early warning that is mitigating natural signs, and still preserving the local wisdom of cooperation which has been in solving problems of the village community, as well as the importance of village officials motivating the community at every socialization activity or institutionalized village meeting.
Team Approach: Spinopelvic Dissociation
Authors: Wanner John Paul , Tatman Lauren , Stephens Byron , Mitchell Phillip 
Published: November 2021

» Spinopelvic dissociation is a complex and variable injury pattern that requires an integrated, multidisciplinary team including orthopaedic trauma and spine surgeons.» Protocols and efficient channels of communication should be in place at tertiary Level-I trauma centers to ensure appropriate and timely treatment of patients with spinopelvic dissociation.» Patients with spinopelvic dissociation may present with acute neurological deficits and impending cauda equina syndrome, necessitating urgent, coordinated care.» Lumbopelvic fixation with sacroiliac screws yields a stable, multiplanar construct that connects the spine to the pelvis and allows for early mobilization.
Ichnofabric analysis as a tool for characterization and differentiation between calcareous contourites and calciturbidites
Authors: Miguez-Salas Olmo , RodrÍguez-Tovar Francisco J. 
Published: November 2021

ABSTRACTThe Eocene–Miocene Cyprus paleoslope system records complex deep-marine sedimentation comprising background vertical settling of autochthonous pelagic–hemipelagic particles (chalks) which were punctuated by calcareous bottom currents (contourites) and gravity flows (calciturbidites). The Eocene Lefkara Formation at the Petra Tou Romiou beach section (Cyprus) shows the incidence of deep-marine bottom currents and distal turbiditic episodes in a context of pelagic–hemipelagic sedimentation. Trace-fossil analysis of this section, using an ichnofabric approach (i.e., ichnodiversity, Bioturbation Index, Bedding Plane Horizontal Index and crosscutting relationships), was conducted to precisely describe the paleoenvironmental conditions of this complex setting. Ichnofabric analysis allow the characterization and differentiation of sporadic turbiditic events that disrupted both pelagic–hemipelagic and contourite deposition. Calciturbidite intervals show ichnofabrics consisting of postdepositional U-shaped traces (i.e., Arenicolites isp., ?Diplocraterion isp.,) and vertical borings typical of consolidated substrates. High-energy sandy contourite deposits are dominated by horizontal deposit-feeder traces and the development of ichnofabrics with Planolites isp., and Thalassinoides isp. The record of ichnofabrics with slightly deformed Planolites in the interbeds of sandy contourites or in the transition between the facies reveals variations in sedimentation in the bi-gradational contourite succession, and can potentially act as an indicator of depositional hiatus.
Extra-Neural Signals From Severed Nerves Enable Intrinsic Hand Movements In Transhumeral Amputations
Authors: Ahkami Bahareh , Mastinu Enzo , Earley Eric , Ortiz-Catalan Max 
Published: November 2021

Abstract
Robotic prostheses controlled by myoelectric signals can restore limited but important hand function in individuals with upper limb amputation. The lack of individual finger control highlights the yet insurmountable gap to fully replace a biologic hand. Implanted electrodes around severed nerves have been used to elicit sensations perceived as arising from the missing limb, but using such extra-neural electrodes to record motor signals that allow for the decoding of phantom movements has remained elusive. Here, we showed the feasibility of using signals from non-penetrating neural electrodes to decode intrinsic hand and finger movements in individuals with above-elbow amputations. We found that information recorded with extra-neural electrodes alone was enough to decode phantom hand and individual finger movements with high accuracy, and as expected, the addition of myoelectric signals reduced classification errors both in offline and in real-time decoding.