bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of duloxetine compared with opioid for postoperative pain control following total knee arthroplasty
Authors: Kim Man Soo , Koh In Jun , Choi Keun Young , Yang Sung Cheol , In Yong 
Published: July 2021

Background
The purpose of this study was to assess the efficacy of duloxetine as an alternative to opioid treatment for postoperative pain management following total knee arthroplasty (TKA).

Methods
Among 944 patients, 290 (30.7%) of patients received opioid or duloxetine for pain control for 6 weeks when the pain Visual Analogue Scale (VAS) score was greater than 4 out of 10 at the time of discharge. 121 patients in the Opioid group and 118 in the Duloxetine group were followed up for more than one year. Preoperative and postoperative patient reported outcome measures (pain VAS score, Western Ontario and McMaster Universities OA Index (WOMAC) score were compared. The rate of further drug prescription (opioid or duloxetine) after 6 weeks of first prescription, 30-day readmission rate, and side effects were also investigated.

Results
There was no significant difference in pain VAS score, WOMAC Pain and Function score, at each time point between before and after surgery (all p>0.05). Fifteen (9.8%) patients in the opioid group and six (4.4%) patients in the duloxetine group were prescribed additional medication after first 6 weeks, showing no significant (p>0.05) difference in proportion. The 30-day readmission rate and the incidence of side effects were also similar (all p>0.05). There was no difference in the incidence of side effects between the two groups (p>0.05).

Conclusion
Duloxetine and opioid did not show any difference in pain control, function, and side effects for up to one year after TKA. Although large-scale randomized controlled trials are still required to further confirm the side effects of duloxetine, it can be considered as an alternative to opioid for postoperative pain control following TKA.
Investigating the Effect of Brand Equity on Rural Tourism Development with the Mediating Role of Word-of-Mouth Advertising. Case Study: Pristine Villages of Zanjan Province
Authors: AZIMI Hossein 
Published: July 2021

In recent years, due to the expansion of urban life, many people tend to travel to quiet and pristine environments. Therefore, the development of rural tourism can be one of the most important ways to generate income and economic development. In terms of purpose, this research is application-oriented and is descriptive-analytic in terms of method of work. The statistical population of the study includes all tourists visiting the pristine villages of Zanjan province. Sampling method was available sample for 384 individuals. Data collection was based on a localized questionnaire. The validity of the questionnaire was confirmed by content and construct validity (KMO = 0.812) and its reliability was confirmed by Cronbach's alpha coefficient (0.903). Descriptive and inferential statistical methods were used for data analysis. SPSS and LISREL were used for descriptive and inferential analysis. The results of the study using the structural equation model indicate that there is a positive and significant relationship between brand equity and rural tourism development.
How Do Undergraduate Tourism Students Perceive the Service Quality in their Educational Institution? An Assessment Using the SERVQUAL Framework
Authors: FUCHS Kevin 
Published: July 2021

Tourism education is an important component and contributor to the tourism industry's global success, particularly as technology and innovation become more prevalent in the hospitality and tourism sectors around the world. Several studies have been conducted on student perceptions of tourism education and the tourism industry's long-term viability in the current and future environment. The importance of a capable, competent, passionate, and dedicated workforce in the service industries in general, and the tourism industry in particular, cannot be overstated. Related studies have also suggested that in the service sector, workers' optimistic attitudes about their work are critical for customer loyalty and satisfaction. Service quality and customer service are leading principles in the business world. Assessing educational service quality is important for encouraging and providing feedback on the effectiveness of educational plans and their execution as higher education institutions compete for competitive advantages and high service quality. In a number of universities, as well as further afield, monitoring student satisfaction with education quality has become an important part of the educational process. This study shows how to use the SERVQUAL system to measure student satisfaction in a more effective way.It entails the use of the SERVQUAL methodology to query and survey five factors related to student services. The proposed instrument was tested on 400 undergraduate tourism students at a large regional university in Thailand. The approach's utility in collecting tourism students' impressions, evaluating them, and reducing them to a form usable by management as an off-the-shelf service quality evaluation tool is demonstrated by rigorous study.
ON EVEN-TO-ODD MEAN LABELING OF SOME TREES
Authors: Casinillo Leomarich F 
Published: July 2021

Let G=(V(G), E(G)) be a connected graph with order |V(G)|=p and size |E(G)|=q. A graph G is said to be even-to-odd mean graph if there exists a bijection function phi:V(G) to {2, 4, ..., 2p} such that the induced mapping phi^*:E(G) to {3, 5, ..., 2p-1} defined by phi^*(uv)=[phi(u)+phi(v)]/2 for all uv element of E(G) is also bijective. The function is called an even-to-odd mean labeling of graph . This paper aimed to introduce a new technique in graph labeling. Hence, the concepts of even-to-odd mean labeling has been evaluated for some trees. In addition, we examined some properties of tree graphs that admits even-to-odd mean labeling and discussed some important results.
NILAI KETAKTERATURAN TOTAL DARI EMPAT COPY GRAF BINTANG
Authors: Marzuki Corry Corazon , Sari Yusnita , Abdussakir Abdussakir , Aryani Fitri 
Published: July 2021

Misalkan adalah suatu graf dan adalah bilangan bulat positif. Pelabelan- total pada graf adalah suatu pemetaan Bobot titik dinyatakan dan bobot sisi dinyatakan Suatu pelabelan- total dikatakan tak teratur total, jika bobot setiap titik berbeda dan bobot setiap sisi berbeda. Nilai ketakteraturan total (totally irregularity strength) dari graf dinotasikan dengan adalah nilai minimum atau label terbesar minimum yang digunakan untuk melabeli graf dengan pelabelan-k total tak teratur total. Dalam makalah ini diperoleh nilai ketakteraturan total 4 copy graf bintan Sn adalah dengan merupakan bilangan bulat positif dan
Deligne–Lusztig duality on the stack of local systems
Authors: Beraldo Dario 
Published: July 2021

Abstract
In the setting of the geometric Langlands conjecture, we argue that the phenomenon of divergence at infinity on

Bun
G

{\operatorname{Bun}_{G}}

(that is, the difference between

!

{!}

-extensions and

*

{*}

-extensions) is controlled, Langlands-dually, by the locus of semisimple

G
ˇ

{{\check{G}}}

-local systems.
To see this, we first rephrase the question in terms of Deligne–Lusztig
duality and then study the Deligne–Lusztig functor

𝖣𝖫
G
spec

{\mathsf{DL}_{G}^{\mathrm{spec}}}

acting on the spectral Langlands DG category

IndCoh
𝒩

⁢

(

LS
G

)

{{\mathrm{IndCoh}}_{\mathcal{N}}({\mathrm{LS}}_{G})}

.
We prove that

𝖣𝖫
G
spec

{\mathsf{DL}_{G}^{\mathrm{spec}}}

is the projection

IndCoh
𝒩

⁢

(

LS
G

)

↠

QCoh
⁢

(

LS
G

)

{{\mathrm{IndCoh}}_{\mathcal{N}}({\mathrm{LS}}_{G})\twoheadrightarrow{\mathrm{%
QCoh}}({\mathrm{LS}}_{G})}

, followed by the action of a coherent D-module

St
G

∈

𝔇
⁢

(

LS
G

)

{{\mathrm{St}}_{G}\in\mathfrak{D}({\mathrm{LS}}_{G})}

, which we call the Steinberg
D-module.
We argue that

St
G

{{\mathrm{St}}_{G}}

might be regarded as the dualizing sheaf of the locus of semisimple G-local systems.
We also show that

𝖣𝖫
G
spec

{\mathsf{DL}_{G}^{\mathrm{spec}}}

, while far from being conservative, is fully faithful on the subcategory of compact objects.
A microstrip planar lowpass filter with ultra-wide stopband using hexagonal-shaped resonators
Authors: Jiang Shu , Wang Wenbo , Ren Le 
Published: July 2021

Abstract
A microstrip planar lowpass filter with ultra-wide stopband up to 40 GHz is presented. The filter is designed based on four types of hexagonal-shaped resonators, producing multiple transmission zeroes and extending the stopband. The high-impedance transmission line is folded to make the circuit more compact and form the coupling gaps between the adjacent resonators. A pair of folded open stubs are added to enhance the cut-off rate. As a result, an ultra-wide stopband with 23rd-harmonic suppression has been attained. A demonstration filter has been designed and fabricated with 3 dB cut-off frequency of 1.70 GHz. The measured results show that the relative stop bandwidth of the low-pass filter (LPF) is 182% with suppression level of 25 dB, covering 1.85–40 GHz. The functional area size of the filter is 21.50 × 21.70 mm, which corresponds to 0.198λ

g
× 0.200λ

g
(λ

g
is the guided wavelength at 3 dB cut-off frequency).
Evaluation of quasi-geoid model based on astrogeodetic measurements: case of Latvia
Authors: Morozova K. , Jäger R. , Zarins A. , Balodis J. , Varna I. , Silabriedis G. 
Published: July 2021

AbstractSince the development of GNSS techniques, the determination of a precise quasi-geoid model has become even more actual. In terms of this project the staff of the Institute of Geodesy and Geoinformatics (GGI) has developed a new quasi-geoid model based on DFHRS (Digital Finite-element Height Reference Surface) approach additionally using astrogeodetic measurements – vertical deflections (VD), which can be observed by a Digital zenith camera. This paper evaluates a quasi-geoid model results based on vertical deflections, as a study area using the territory of Latvia: the standard deviation of the solution is equal to 0.006 m with observation residuals after the adjustment of minimum and maximum differences −0.012 and 0.012 accordingly. The standard deviation of quasi-geoid heights and h-H values from LGIA database is equal to 0.012 m with minimum and maximum differences −0.026 and 0.025 accordingly. The post-processed terrestrial VD observations have been compared to VD derivatives from EGM2008 and GGMplus geopotential models. The developed quasi-geoid has been compared to the national quasi-geoid model LV’14 and to the Scandinavian NKG2015.
Antimicrobial activity of Centella asiatica and Gigantochloa apus
Authors: Mudaliana Siti 
Published: July 2021

Abstract

Objectives
Antibiotic treatments can create multi-drug resistance among several pathogens. There is a need for an antibiotic alternative to overcome this problem. In Indonesia, Centella asiatica (Asiatic pennywort) and Gigantochloa apus (string bamboo) are two common medicinal plants used to treat tuberculosis, diarrhea, and other symptoms. This study was done to compare the antimicrobial activity of C. asiatica and G. apus against five pathogenic bacteria, i.e., Mycobacterium tuberculosis H37Rv strain, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Salmonella typhi.

Methods
The ethanol extracts of C. asiatica, and G. apus shoot were obtained by using speed extractor, pressure, and temperature extraction. The phytochemical contents of each extract were screened. The ethanol extract’s antimycobacterial activity was determined using Lowenstein Jensen (LJ) medium and antibacterial activity was determined using Kirby–Bauer methods on Mueller Hinton agar (MHA).

Results
The phytochemical analysis showed that G. apus extract contains alkaloids and tannins, whereas C. asiatica extract contains flavonoids, alkaloids, saponins, and tannins. This study showed that G. apus inhibited the growth of M. tuberculosis H37Rv strain and S. typhi. C. asiatica showed antimicrobial activity against all pathogenic bacteria tested, except B. subtilis.

Conclusions
Both medicinal plants extract can inhibit the growth of five pathogenic bacteria tested, thus, have the potential as an alternative treatment, or complementary, to treat the pathogenic bacterial infection.
Variation concentration effect of propyleneglycol, glycerin, and polyethyleneglycol 400 to physical properties and dissolution rate of loratadine liquisolid tablet
Authors: Eryani Mikhania Christiningtyas , Hendradi Esti , Siswandono  
Published: July 2021

Abstract

Objectives
This study aimed to evaluate the variation concentration effect of propyleneglycol, glycerin, and polyethyleneglycol 400 as a nonvolatile solvent on the physical properties and dissolution rate of the loratadine liquisolid tablet.

Methods
The tablet was formulated into 10 formulas, where nine were liquisolid and one was conventional (CT). The concentration of propyleneglycol, glycerin, and polyethyleneglycol used in liquisolid tablets were 14, 15, and 16%. Furthermore, the mixture was evaluated based on flow properties and compressibility index. The tablet was evaluated based on hardness, friability, disintegration time, and dissolution, and the data obtained was evaluated with ANOVA or Kruskal–Wallis statistic program.

Results
The result showed that flow properties, disintegration time, and dissolution have a significant value less than 0.05. The tablet friability for all concentration solvents, hardness at 14 and 15% solvent concentration, and compressibility index at 15 and 16% have significant value more than 0.05. The 16% propyleneglycol type solvent concentration tablet has the physical properties and contains the best solution

Conclusions
From the result, it is reasonable to conclude that F7 is the tablet with all the physical properties and the best dissolution.
Synthesis, ADMET predictions, molecular docking studies, and in-vitro anticancer activity of some benzoxazines against A549 human lung cancer cells
Authors: Sulistyowaty Melanny Ika , Widyowati Retno , Putra Galih Satrio , Budiati Tutuk , Matsunami Katsuyoshi 
Published: July 2021

Abstract

Objectives
This study aims to synthesize a series of benzoxazines (1–5) to be examined as an epidermal growth factor receptor (EGFR) inhibitor by in-silico study. The overexpression of EGFR causes the growth of normal lung cells to become uncontrollable, which may lead to cancer formation. We also conducted the absorption, distribution, metabolism, excretions and toxicity (ADMET) properties evaluation and also examined in vitro anticancer assay on human lung cancer cells line, which is A549.

Methods
Benzoxazines (1–5) were synthesized by reacting anthranilic acid and benzoyl chlorides. The structures of the compounds were determined with 1H, 13C-NMR, HRMS, UV and FT-IR spectrometric methods. Prediction of ADMET was using online pkCSM, and the molecular docking studies were using MVD with EGFR-TKIs as the target (PDB ID: 1M17). In vitro assay of anticancer activity was performed by MTT assay.

Results
Compounds 1–5 were successfully synthesized in good yields (71–84%). The ADMET prediction showed that benzoxazines are able to be absorbed through GIT, metabolized by CYP 450, and not hepatotoxic. The title compounds have a greater Moldock Score than Erlotinib, and 3 has the highest activity against A549 compared with other benzoxazines, IC50=36.6 μg/mL.

Conclusions
Compound (3) more active as anticancer against Human cancer cells line compared with other benzoxazines.
N-nitrosodiethylamine induces inflammation of liver in mice
Authors: Cahyani Devy Maulidya , Miatmoko Andang , Hariawan Berlian Sarasitha , Purwantari Kusuma Eko , Sari Retno 
Published: July 2021

Abstract

Objectives
For designing early treatment for liver cancer, it is important to prepare an animal model to evaluate cancer prevention treatment by using inflammation disease. The hepatocarcinogenic N-Nitrosodiethylamine (NDEA) has been reportedly able to produce free radicals that cause liver inflammation leading to liver carcinoma. This study aimed to evaluate the inflammation disease model of mice induced with hepatocarcinogenic NDEA for five weeks induction.

Methods
The BALB-c mice were induced with NDEA 25 mg/kg of body weight once a week for five weeks intraperitonially and it was then evaluated for the body weight during study periods. The mice were then sacrificed and excised for evaluating their organs including physical and morphological appearances and histopathology evaluations.

Results
The results showed a significant decrease of body weight of mice after five times induction of 25 mg NDEA/kgBW per week intraperitonially. Different morphological appearances and weight of mice organs specifically for liver and spleen had also been observed. The histopathology examination showed that there were hepatic lipidosis and steatohepatitis observed in liver and spleen, respectively that might indicate the hepatocellular injury.

Conclusions
It can be concluded that inducing mice with NDEA intraperitonially resulted in fatty liver disease leading to progress of cancer disease.
Smart Wearable and Collaborative Technologies for the Operator 4.0 in the Present and Post-COVID Digital Manufacturing Worlds
Authors: Romero David , Wuest Thorsten , Keepers Makenzie , Cavuoto Lora A. , Megahed Fadel M. 
Published: July 2021

Abstract
This paper addresses the potential of smart wearable and collaborative technologies in support of healthier, safer, and more productive shop floor environments during the present and post– coronavirus 2019 pandemic emerging digital manufacturing worlds. It highlights the urgent need to “digitally transform” many high-touch shop floor operations into low-touch or no-touch ones, aiming not only at a safer but also more productive return to work as well as a healthier continuity of production operations in more socially sustainable working environments. Furthermore, it discusses the interrelated roles of people, data, and technology to develop smart and sustainable shop floor environments. Lastly, it provides relevant recommendations to the key business units in a manufacturing enterprise in regard to the adoption and leverage of smart wearable and collaborative technologies on the shop floor in order to ensure the short- and long-term operation of a factory amid the coronavirus 2019 pandemic and the future of production and work in the Industry 4.0 era.
The therapeutic response of somatotropinomas according to the T2-weighted signal intensity on the MRI
Authors: Scânteie Carla-Liana , Leucuța Daniel-Corneliu , Ghervan Cristina 
Published: July 2021

Background and aim. Identifying the predictive factors of tumoral and hormonal answer of somatotropinomas to the medical treatment with somatostatin analogs represent an important element for treatment management. The aim of this study was to assess the therapeutic answer of the somatotropinomas according to the T2-weighted signal intensity on the MRI.
Methods. We included 31 acromegalic patients, mean age 51.35 ± 10.37 years, who underwent surgery. The patients were divided according to the T2-weighted MRI signal intensity - hypointense, hyperintense and isointense - of the GH-secreting pituitary adenoma and were evaluated after surgery, 3, 6 and 12 months with somatostatin analogs therapy.
Results. 16 (51.61%) somatropinomas were hypointense, 9 (29.03%) were hyperintense and 6 (19.35%) were isointense. The median IGF-1 and GH level decreased significantly in macroadenomas (p<0.001, p<0.001, respectively), whereas GH decreased significantly only in microadenomas (p=0.010). A significant statistical correlation was found between IGF-1 or GH levels and tumor volume before surgery (Spearman=0.38, p<0.001; Spearman=0.64, p<0.001, respectively) and after surgery (Spearman=0.61, p=0.001; Spearman=0.74, p<0.001). The percentage of optimally controlled patients increased from 12.9% after surgery, to 28.57% after 12 months with somatostatin analogs. The highest percentage of optimally controlled patients with somatostatin analogs treatment was in hypointense somatotropinomas (50%).
Conclusion. The T2-weighted MRI signal intensity classifies the somatotropinomas into groups with certain evolutive and medical treatment response particularities, of which we found that the hypointense somatotropinomas have a better therapeutic response after surgery and after long-term treatment with somatostatin analogs.
Pembuatan prototipe penentu kesegaran ikan patin Berbasis sensor TCS 230
Authors: Catur Pramono Adi  , Tina Fransiskha C.P.  , Panjaitan Pola , Yuda Herdiansyah  
Published: July 2021

Prototipe penentu kesegaran ikan patin merupakan alat uji coba untuk mengetahui tingkat kesegaran ikan patin berdasarkan tingkat warna daging yang berbentuk Nilai R,G,B (Red, Green dan Blue). Dalam pembuatannya prototipe ini memerlukan Arduino Atmega 2560 yang berfungsi sebagai otak dari semua komponen, sensor TCS 230 yang berfungsi mendeteksi warna berdasarkan nilai red, green dan blue, kemudian LCD 20×4 yang berfungsi sebagai display hasil deteksi. Sasis berbentuk kubus dengan bahan besi ringan serta papan yang mampu menahan air serta mudah dibersihkan. Prototipe ini mempunyai dimensi panjang 28 cm, lebar 25 cm, dan tinggi 18 cm. Dalam cara kerjanya, ikan patin dimasukan ke dalam kubus dimana di dalam kubus tersebut terpasang sensor TCS 230 yang kemudian akan mendeteksi warna daging yang setelah itu dikonversi dalam nilai R,G,B. Arduino mengklarifikasi pembacaan sensor yang kemudian diteruskan ke LCD sebagai output hasil uji. Berdasarkan hasil pengujian data confusion matrix, prototipe ini memiliki nilai akurasi data sebesar 80%, tingkat presisi positif sebesar 83%, dan presisi negatif sebesar 67%. Hasil pengujian prototipe pengkategorian kesegaran ikan patin mengahasilkan persentase keberhasilan sebesar 84,4 %.
Pemetaan Zona Daerah Penangkapan Ikan Dengan Bagan Perahu Cungkil Berdasarkan Time Series Pada Perairan Teluk Bone
Authors: Arham Rumpa  , Muhammad maskur  , Fajar Hermawan  , Amir Yusuf  
Published: July 2021

Penelitian ini bertujuan untuk mengidentifikasi aspek teknik bagan perahu cungkil, pemetaan zona daerah penangkapan ikan berdasarkan time series bulanan, komposisi hasil tangkapan target spesies berdasarkan time series bulanan dan komposisi hasil tangkapan target spesies berdasarkan jarak dan kedalaman perairan. Penelitian dilaksanakan Maret 2020 - Februari 2021, lokasi penelitian di Teluk Bone. Data dipetakan menggunakan rekaman posisi pada GPS yang kemudian di overlay kedalam tampilan aplikasi Novianic Asia Afrika. Penelitian bertujuan untuk mengidentifikasi aspek teknis bagan perahu cungkil, pemetaan zona daerah penangkapan ikan berdasarkan time series bulanan, komposisi hasil tangkapan berdasarkan musim jarak dan kedalaman perairan. Hasil analisis menemukan bahwa alat tangkap bagan cungkil termasuk kedalam klasifikasi bagan perahu sama seperti bouke ami dengan metode pengoperasiannya menggunakan lampu (light fishing) sebagai daya tarik mengumpulkan ikan yang bersifat (phototaxis), zona Daerah Penangkapan Ikan (DPI) berdasarkan time series bulanan memperlihatkan kosentrasi penangkapan berada pada perairan pesisir timur Teluk Bone, Proporsi ikan banyak tertangkap didominasi Ikan Teri (Steleporus devisi), Cumi-cumi (Loligo sp), Tembang (Sardinella fimbriata) dan kosentrasi tertangkap pada jarak 0,4 – 2,4 mill dengan kedalaman 15 – 50 meter dan Tongkol lisong (Auxis rochei), Layang (decapterus ruselli) dan Kembung (Rastrelliger kanagurta) dengan jarak 12 - 24 mil dari pantai pada kedalaman ≥ 200 meter.