bluuebunny/crossref_metadata_2025_split huggingface dataset:
IncRNA MVIH correlates with disease features, predicts treatment response and survival in pediatric acute myeloid leukemia
Authors: Xue Hongjuan , Gao Haili , Xia Hong , Li Shaofei , Li Na , Gao Chao , Duan Yuwen , Ren Yanfei , Zhang Henglu , Liu Jingzheng , Gao Wei 
Published: March 2021

AbstractObjectiveLong non‐coding RNA microvascular invasion in hepatocellular carcinoma (lnc‐MVIH) is correlated with unfavorable prognosis in several malignancies, while limitedly studied in pediatric acute myeloid leukemia (AML). This study aimed to investigate the correlation of lnc‐MVIH with disease features, response to induction therapy, and survival in pediatric AML patients.MethodsA total of 129 de novo pediatric AML patients who were retrospectively analyzed and 60 children with non‐malignant hematological diseases who underwent bone marrow examination were reviewed as controls. Bone marrow mononuclear cells (BMMCs) were isolated from all participants to detect lnc‐MVIH expression by reverse transcription‐quantitative polymerase chain reaction. The complete remission status after 1 course of induction therapy, event‐free survival, and overall survival of pediatric AML patients were recorded.ResultsLnc‐MVIH was upregulated in pediatric AML patients compared with controls (p < 0.001). In pediatric AML patients, lnc‐MVIH was correlated with increased bone marrow blasts, less inv(16) or t(16;16) abnormity, and higher Chinese Medical Association (CMA) risk stratification (all p < 0.05), whereas its correlation with National Comprehensive Cancer Network (NCCN) risk stratification was not statistically significant (p = 0.098). As for prognosis, lnc‐MVIH high expression patients presented with lower complete response rate to 1 course of induction therapy (61.5% vs. 79.7%, p = 0.024), shorter event‐free survival (median 12.0 months vs. 22.0 months, p = 0.006), and overall survival (median 28.0 months vs. 42.0 months, p = 0.043) compared with lnc‐MVIH low expression patients.ConclusionLnc‐MVIH correlates with poor treatment response and unfavorable survival in pediatric AML.
Immunoinformatic analysis of structural and epitope variations in the spike and Orf8 proteins of SARS‐CoV‐2/B.1.1.7
Authors: Hussain Mushtaq , Shabbir Sanya , Amanullah Anusha , Raza Fozia , Imdad Muhammad J. , Zahid Sahar 
Published: March 2021

AbstractA newly emerged strain of SARS‐CoV‐2 of B.1.1.7 lineage has caused a significant surge in the SARS‐CoV‐2 infections in the UK. In this study, changes in the epitopes of spike and orf8 proteins in SARS‐CoV‐2 of B.1.1.7 lineage were investigated. Genomic alignment of the SARS‐CoV‐2/B.1.1.7 with SARS‐CoV‐2/Wuhan showed the presence of several mutations in orf1a/b, spike, orf8, and N proteins of SARS‐CoV‐2/B.1.1.7. Molecular models of spike and orf8 proteins were constructed by homology modeling. Superimposition between the spike proteins of SARS‐CoV‐2/Wuhan and SARS‐CoV‐2/B.1.1.7 showed noticeable variations in the spatial orientation in Val70‐Asn74 and Thr250‐Ser255 regions. This may have also resulted in the extension of the epitopic region at Ser244‐Gly249 in the SARS‐CoV‐2/B.1.1.7 spike protein. Superimposition of the SARS‐CoV‐2/B.1.1.7 spike protein over Fab‐spike protein complexes of SARS‐CoV‐2/Wuhan also showed subtle variations in the antibody binding affinity targeting the N‐terminal domain of the spike protein. Epitopic variations were also observed between the corresponding orf8 regions of SARS‐CoV‐2/Wuhan and SARS‐CoV‐2/B.1.1.7. Moreover, the presence of a stop codon at position 27 in orf8 connotes the emergence of two frames (orf8a and orf8b) in SARS‐CoV‐2, which further hampers its extracellular secretion, and in turn, immunogenicity. The findings of the present study could further be used to develop targeted immunotherapeutics.
Cardiac Involvement in Movement Disorders
Authors: Rossi Malco , Wainsztein Nestor , Merello Marcelo 
Published: March 2021

ABSTRACTBackgroundSeveral conditions represented mainly by movement disorders are associated with cardiac disease, which can be overlooked in clinical practice in the context of a prominent primary neurological disorder.ObjectivesTo review neurological conditions that combine movement disorders and primary cardiac involvement.MethodsA comprehensive and structured literature search following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses criteria was conducted to identify disorders combining movement disorders and cardiac disease.ResultsSome movement disorders are commonly or prominently associated with cardiac disease. Neurological and cardiac symptoms may share underlying physiopathological mechanisms in diseases, such as Friedreichʼs ataxia and Wilsonʼs disease, and in certain metabolic disorders, including Refsum disease, Gaucher disease, a congenital disorder of glycosylation, or cerebrotendinous xanthomatosis. In certain conditions, such as Sydenhamʼs chorea or dilated cardiomyopathy with ataxia syndrome (ATX‐DNAJC19), heart involvement can present early in the course of disease, whereas in others such as Friedreichʼs ataxia or Refsum disease, cardiac symptoms tend to present in later stages. In another 68 acquired or inherited conditions, cardiac involvement or movement disorders are seldom reported.ConclusionsAs cardiac disease is part of the phenotypic spectrum of several movement disorders, heart involvement should be carefully investigated and increased awareness of this association encouraged as it may represent a leading cause of morbidity and mortality.
Application of Ferrans et al.'s conceptual model of health‐related quality of life: A systematic review
Authors: Duangchan Cherdsak , Matthews Alicia K. 
Published: March 2021

AbstractFerrans, Zerwic, Wilbur, and Larson proposed the conceptual model of health‐related quality of life (HRQOL) in 2005 to explicate the constructs associated with HRQOL and to describe the associations among those constructs. In this systematic review, the authors aimed to describe empirical studies that used Ferrans et al.'s model and to examine the evidence related to the hypothesized model concepts. This review followed Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. Relevant articles were identified using Crossref, CINAHL, and PubMed. To be included, studies had to employ the model as a theoretical framework and be published in English between 2005 and 2020. Type of theory use was coded using four designations: informed by theory, applied theory, testing theory, and building theory. Thirty‐one studies were included. Most studies involved adult patients with chronic illnesses (n = 20) and were conducted in Western countries (n = 22). The most common type of theory use was testing theory (74.19%). Among the seven concepts in Ferrans et al.'s model, all 20 hypothesized associations were tested and 19 were supported by study results. The three associations most frequently supported were between symptoms and functional status (n = 13), environmental characteristics and quality of life (n = 10), and individual characteristics and functional status (n = 8). No studies found an association between environmental characteristics and biological function. Our review found that Ferrans et al.'s model has been used extensively to guide HRQOL research. An emerging body of research provides preliminary support for the associations hypothesized in the model. Additional research is needed to confirm the hypothesized associations among model concepts.
The effect of different grafting extent of PBO‐MoS2 hybrids on the tribological performance of TPI‐based composites at high temperatures
Authors: Yan Yunfeng , Meng Zhaojie , Wang Jianzhang , Yan Fengyuan 
Published: March 2021

AbstractThe self‐assembled hybrids were synthesized as a kind of filler with the function of reinforcing and lubricating, by which can improve its dispersion in the matrix, and enhance the interfacial adhesion with the matrix. However, the effect of the amount of grafting on the hybrid properties is still unclear. In this study, a series of antiwear hybrids with different grafting amount were synthesized and further be used to reinforce thermoplastic polyimide matrix. The method of comparative analysis had been applied to analyze the microstructural morphology, thermal property, mechanical property, and high temperature tribological behavior of these composites. The results indicated that with the increasing grafting amount of MoS2 on the PBO fiber surface in a certain range, the integrated performance of the composite increases.
Mechanical Properties and Thermal Decomposition Behaviors of Hydroxyl‐Terminated Polybutadiene/Glycerol Propoxylate Blend and Its Application to Ammonium Nitrate‐Based Propellants
Authors: Kohga Makoto , Togashi Ryoto 
Published: March 2021

AbstractHydroxyl‐terminated polybutadiene (HTPB) is commonly used as a binder ingredient in composite propellants. In this study, a plasticizer was added to the binder to promote its plasticity and flexibility. Glycerol propoxylate (GPO) is a triol material with a zigzag structure, and it has one oxygen atom in a repeating unit. GPO would be a good plasticizer for HTPB binder to obtain good elasticity; furthermore, it would be suitable for improving the burning characteristics of the HTPB propellant. The addition of GPO to the HTPB binder was effective in extending the pot life and improving the mechanical properties of the propellant. The thermal decomposition behaviors of the HTPB/GPO blends were almost the same as that of the HTPB binder, except that the beginning consumption temperature of the blends was lower than that of HTPB. The ignitability at low pressure for the ammonium nitrate‐based propellant was improved by using the HTPB/GPO binder, whereas GPO did not enhance the burning rate of the propellant.
Synthesis, Antimicrobial Activity, Anti‐HIV Activity, and Molecular Docking of Novel 5‐, 6‐ and 7‐Membered Ring (1H‐Pyrrol‐2‐yl)aminolactams
Authors: Jassem Ahmed Majeed , Dhumad Adil Muala 
Published: March 2021

AbstractAn efficient method has been developed for the synthesis of novel 5‐, 6‐ and 7‐membered ring (1H‐pyrrol‐2‐yl)aminolactams 5 a–f. This method featured Ugi‐4‐center‐3‐component reaction (U4 C3 C) followed by a post‐transformation reaction. All the newly synthesized (1H‐pyrrol‐2‐yl)aminolactams 5 a–f have been screened against six microbial species and the results revealed that these lactams exhibited moderate to good activity. These lactams were also tested in an in vitro for their antiviral activity against of HIV‐1 and HIV‐2 replication using MT‐4 cells. The testing results showed that compound 5 f is the only compound in the set lactams exhibiting a significant inhibition against HIV‐1 replication in cell line with EC50 value of 2.74±1.08 μM (CC50 of 18.93±4.0 μM), and SI 6. In addition, the compound 5 f was docked with essential proteins of HIV‐1 and HIV‐2 reverses transcriptase (RT), including HIV‐1 and HIV‐2 integrases strand proteins (PDB ID: 1EP4, 1FK9, 1HNV, 1VRU, 3DLE, 3DLG, and 3MEC). The docking results revealed that important hydrogen bond interactions and hydrophobic interactions were found between the compound 5 f and the essential amino acids residues of HIV‐1 and HIV‐2 (RT) proteins.
Introduction
Authors: Ryoo Jungwoo , Winkelmann Kurt 
Published: March 2021

AbstractThe practice of educating students in college-level science, technology, engineering, and math (STEM) subjects is influenced by many factors, including education research, governmental and school policies, financial considerations, technology limitations, and acceptance of innovations by faculty and students. Working together, stakeholders in STEM higher education must find creative ways to address the increasing need for a diverse US workforce with a strong STEM background (President’s Council of Advisors on Science and Technology 2012) and the need for a more STEM-literate general population (National Research Council 2012).
Personalized and Adaptive Learning
Authors: Taylor Deborah L. , Yeung Michelle , Bashet A. Z. 
Published: March 2021

AbstractPersonalized and adaptive learning has been touted to be one of the most promising emerging tools for increasing student learning and student success. Yet, the terms are neither precise nor clearly defined at this time, thus making it difficult for institutions of higher education to adopt and implement a learning approach using technology that is in its infancy and not clearly understood by those who will be utilizing it. One goal of this chapter is to define adaptive and personalized learning as it is used at this time in the hopes that as the technology evolves the promise of increased student learning can come to fruition. Adaptive learning personalizes learning by continuously evaluating each student’s performance in real time and creating an ever-changing individualized learning pathway as directed by artificial intelligence and machine learning, thus increasing learning and student satisfaction.
Multimodal Learning
Authors: Bouchey Bettyjo , Castek Jill , Thygeson John 
Published: March 2021

AbstractThe widespread use of technology in the digital age continually shapes how individuals consume knowledge and learn. In the digital age, ideas are shared and represented in multiple formats and through the integration of multiple modes. Technological advances, coupled with considerations of the changing needs of today’s learners, call for exploring new directions for multimodal teaching and learning. Yet, society’s increasing reliance on, and use of, technologies for communication and learning has introduced expanded forms of meaning-making. Information and communication technologies (ICTs) and the online networks that are facilitated by their use encourage educators to transform the way education is delivered. Learning environments are in need of becoming transformed so students are able to use immersive technologies to expand their learning opportunities. This chapter explores emerging trends and pedagogies in multimodal learning that seek to take advantage of the digital tools, texts, and learning approaches that are continually shaping the ways learning occurs inside and outside of higher education.This chapter is outlined to highlight what is found in the literature on multimodal instruction, what findings were realized at eXploring the Future of Innovative Learning Environments (X-FILEs) workshops, and lastly how multimodal instruction can be used to transform the classroom of the future. Throughout this chapter, readers will get to know a student of the future, Juan Delgado. He attends a 4-year university in Dallas, Texas, and is majoring in Mechanical Engineering taking his Introduction to the Fundamentals of Science course. Each aspect of the learning process as it relates to multimodal instruction in 2023 is outlined through the experiences of Juan to situate the impact to learners.
Emergent Guiding Principles for STEM Education
Authors: Ragan Lawrence C. , Ramirez Villarin Lorraine J. 
Published: March 2021

AbstractThis chapter highlights a series of guiding principles that emerged from the information collected and collated following the X-FILEs Workshop. The guiding principles were developed from themes that appeared in multiple formats and across most or all technology categories. These propositions can inform and serve as the foundation for the design and development of future STEM education. These nine guiding principles, divided into four clusters, emphasize a learning environment that is student-engaged, flexible, and fluid, provides equitable access and accessibility to all, and is personalized to the learner, co-contributed and multiply-sourced, safe and secure, and ethical.
Older Adults in Hospitals: Health Promotion When Hospitalized
Authors: Helvik Anne-S. 
Published: March 2021

AbstractThe population of older adults (≥60 years) is currently growing. Thus, in the years to come it is expected that a high proportion of patients hospitalized will be in the older age range. In western countries, the proportion of older inpatients is about 40% in the medical and surgical hospitals units. Older people with illness is vulnerable to both physical and cognitive impairments as well as depression. Therefore, a health-promoting perspective and approach are highly warranted in clinical nursing care of older adults in medical hospitals. This chapter focuses on health promotion related to depressive symptoms, impairment in activities of daily living, and cognitive impairment in older hospitalized adults.
Sense of Coherence
Authors: Moksnes Unni Karin 
Published: March 2021

AbstractThis chapter introduces the concept of sense of coherence which is a core concept in the salutogenic model defined by Aron Antonovsky. The salutogenic model posits that sense of coherence is a global orientation, where life is understood as more or less comprehensible, meaningful, and manageable. A strong sense of coherence helps the individual to mobilize resources to cope with stressors and manage tension successfully with the help of identification and use of generalized and specific resistance resources. Through this mechanism, the sense of coherence helps determine one’s movement on the health ease/dis-ease continuum. Antonovsky developed an instrument named Orientation to Life Questionnaire to measure the sense of coherence which exists in two original versions: a 29-item and a 13-item version. This chapter presents the measurement of the sense of coherence and the validity and reliability of the 13-item scale. It gives a brief overview of empirical research of the role of sense of coherence in association with mental health and quality of life and also on sense of coherence in different patient groups including nursing home residents, patients with coronary heart disease, diabetes, cancer, and mental health problems. It also briefly discusses the implications of using salutogenesis in health care services and the importance of implementing this perspective in meeting with different patient groups. The salutogenic approach may promote a healthy orientation toward helping the patient to cope with everyday stressors and integrate the effort regarding how to help the patient manage to live with disease and illness and promote quality of life.
Self-Transcendence: A Salutogenic Process for Well-Being
Authors: Reed Pamela G. , Haugan Gørill 
Published: March 2021

AbstractSelf-transcendence is a concept relevant to understanding how human beings attain or maintain well-being. Not surprisingly, it is similar to other concepts that are in some way linked to human well-being. The purpose of this chapter is to discuss self-transcendence particularly for its empirical support and practical relevance in promoting well-being across the health continuum. Increasing understanding and generating new ideas about self-transcendence may also facilitate continued research into self-transcendence and identification of health-promoting interventions and practices that foster well-being, particularly in difficult life situations.
Handlungsfelder der Landnutzung
Authors: Baum Sarah , Elsasser Peter , Goetzke Roland , Henseler Martin , Hoymann Jana , Kreins Peter 
Published: March 2021

ZusammenfassungMit welchen Maßnahmen eine angepasste Landnutzung zum Klimaschutz beitragen kann, wird anhand von Handlungsfeldern im Siedlungswesen, in der landwirtschaftlichen Landnutzung und forstlichen Handlungsoptionen sektoral veranschaulicht. Es werden die Maßnahmen beschrieben und ihre jeweilige Relevanz hergeleitet. Ferner wird spezifiziert, welche Maßnahmen konkret analysiert werden.
Polynomial identities related to special Schubert varieties
Authors: Cioffi Francesca , Franco Davide , Sessa Carmine 
Published: March 2021

AbstractLet $$\mathcal S$$
S
be a single condition Schubert variety with an arbitrary number of strata. Recently, an explicit description of the summands involved in the decomposition theorem applied to such a variety has been obtained in a paper of the second author. Starting from this result, we provide an explicit description of the Poincaré polynomial of the intersection cohomology of $$\mathcal S$$
S
by means of the Poincaré polynomials of its strata, obtaining interesting polynomial identities relating Poincaré polynomials of several Grassmannians, both by a local and by a global point of view. We also present a symbolic study of a particular case of these identities.
Odour-active compounds in liquid malt extracts for the baking industry
Authors: Rögner Nadine S. , Mall Veronika , Steinhaus Martin 
Published: March 2021

AbstractAn odorant screening by gas chromatography–olfactometry (GC–O) and a crude aroma extract dilution analysis (AEDA) applied to the volatiles isolated from a light and a dark liquid malt extract (LME) by solvent extraction and solvent-assisted flavour evaporation (SAFE) identified 28 odorants. Fifteen major odorants were subsequently quantitated and odour activity values (OAVs) were calculated as ratio of the concentration to the respective odour threshold value (OTV). Important odorants in the light LME included 3-(methylsulfanyl)propanal (OAV 1500), (E)-β-damascenone (OAV 430), and 4-ethenyl-2-methoxyphenol (OAV 91). In the dark LME, sotolon (OAV 780), 3-(methylsulfanyl)propanal (OAV 550), (E)-β-damascenone (OAV 410), acetic acid (OAV 160), and maltol (OAV 120) were of particular importance. To get an insight into the changes during malt extract production, the quantitations were extended to the malt used as the starting material for both LMEs. Addition of a minor amount of water to malt before volatile extraction was shown to be effective to cover the free as well as the bound malt odorants. Results showed that some LME odorants originated from the starting material whereas others were formed during processing. Important process-induced LME odorants included (E)-β-damascenone and 4-ethenyl-2-methoxyphenol in the light LME as well as maltol, sotolon, (E)-β-damascenone, and 2-methoxyphenol in the dark LME. In summary, the odorant formation during LME production was shown to be more important than the transfer of odorants from the malt.