bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptation and implementation of a parenting curriculum in a refugee/immigrant community using a task-shifting approach: A study protocol
Authors: Whitaker Daniel , Self-Brown Shannon , Weeks Erin , O'Connor Mary Helen , Lyons Matthew , Willging Cathleen , Lee NaeHyung , Kumar Jessica L. , Joseph Hannah , Reidy Dennis , Rivers Danielle , Rao Nikita 
Published: May 2021

Abstract
Background Delivering evidence-based interventions to refugee and immigrant families is difficult for several reasons, including language and cultural issues, access and trust issues that can lead to an unwillingness to engage with the typical intervention delivery systems. Adapting both the intervention and the delivery system for evidence-based interventions can make those interventions most appropriate and palatable for the targeted population, increasing uptake and effectiveness. This study focuses on the adaptation of the SafeCare© parenting model, and its delivery through either standard implementation methods via community-based organizations (CBO) and a task-shifted implementation in which members of the Afghans, Burmese, Congolese community will be trained to deliver SafeCare. MethodAn adaptation team consisting of community members, members of CBO, and SafeCare experts will engage a structured process to adapt the SafeCare curriculum for each targeted community. Adaptations will focus on both the model and the delivery of it. Data collection of the adaptation process will focus on documenting adaptations and team member’s engagement and satisfaction with the process. SafeCare will be implemented in each community in two ways: standard implementation and task-shifted implementation. Standard implementation will be delivered by CBOs (n = 120), and task-shifted implementation will be delivered by community members (n = 120). All interventionists will be trained in a standard format, and will receive post-training support. Both implementation metrics and family outcomes will be assessed. Implementation metrics will include ongoing adaptations, delivery of services, fidelity, skill uptake by families, engagement/completion, and satisfaction with services. Family outcomes will include assessments at three time points (pre, post, and six months) of positive parenting, parent-child relationship, parenting stress, and child behavioral health. Discussion The need for adapting of evidence-based programs and delivery methods for specific populations continues to be an important research question in implementation science. The goal of this study is to better understand an adaptation process and delivery method for three unique populations. We hope the study will inform other efforts to deliver health intervention to refugee communities and ultimately improve refugee health.
Production of succinic acid from pineapple peel waste
Authors: Pathanibul Panchalee , Hongkulsup Choosit 
Published: May 2021

Abstract
Background: Succinic acid is a crucial platform chemical for production of various industrially significant compounds. For a sustainable and eco-friendly process, succinic acid synthesis has been shifted towards the fermentative route using renewable biomass substrates. Pineapple consumption and processing generate an immense amount of waste from its non-edible peel portion. As a carbon source, pineapple peel can be valorized for succinic acid bioproduction.
Results: The hydrothermal pretreatment (121°C, 15 min) of pineapple peel waste resulted in the highest sugar release of 35.22 g/L (18 g/L glucose and 17 g/L fructose). The subsequent fermentation of pineapple peel hydrolysate was performed by a natural succinic acid producer, Actinobacillus succinogenes TISTR 1994. When the non-detoxified hydrolysate was used as a sole carbon source, 6.21 g/L of succinic acid was produced from 26.16 g/L of sugars. Additional supplementation of 9 g/L mixed nitrogen source enhanced the formation of succinic acid to 9.96 g/L from roughly the same amount of sugar. The current production conditions using mainly hydrolysate-based medium gave the succinic acid yield of 0.39 g/g sugar suggesting feasibilities for further improvement.
Conclusion: Bio-based succinic acid production was attempted for the first time using the solid pineapple waste as a main starting material. Results demonstrated a proof of concept that the abundant pineapple peel waste can serve as a renewable substrate for a low-cost, value-added bioconversion to succinic acid. Optimization of nutritional composition in hydrolysate is necessary to enhance the yield of succinic acid in future studies.
BnERF114.A1, a Gene Encoding an APETALA2/ETHYLENE RESPONSE FACTOR, Regulates Plant Architecture Through Blocking Auxin Efflux in Apex of Rapeseed Plant
Authors: Lyu Jinyang , Guo Yuan , Du Chunlei , Yu Haibo , Guo Lijian , Liu Li , Wang Xinfa , Zhao Huixian , Hu Shengwu 
Published: May 2021

Abstract
Plant architecture is very important for rapeseed breeding. Here, we reported an ETHYLENE RESPONSE FACTOR (ERF) transcription factor BnERF114.A1 of Brassica napus participating in plant architecture regulation. BnERF114.A1 is a member of ERF family group x-a, encoding a putative protein of 252 aa which consisting of an AP2/ERF domain and a conserved CMX-1 motif. BnERF114.A1 located in nucleus and had transcriptional activity with its functional region located in 142 aa ~ 252 aa of its C-terminus. The GUS staining analysis revealed that BnERF114.A1 highly expressed in leaf primordia, shoot apical meristem, leaf marginal meristem, and reproductive organs. Ectopic expression of BnERF114.A1 in Arabidopsis reduced plant height, increased branch numbers and silique numbers per plants, and finally increased seed yield per plant. Further investigation demonstrated that overexpression of BnERF114.A1 can inhibit IAA efflux and cause accumulation of auxin in apex, and arrest apical dominance in Arabidopsis. The findings suggested BnERF114.A1 could provide a candidate gene for rapeseed plant architecture molecular breeding.
Interferon Regulatory Factor 5 represses oxidative respiration in human and murine macrophages by inhibition of mitochondrial matrix protein GHITM
Authors: Orliaguet Lucie , Ejlalmanesh Tina , Humbert Alexandre , Ballaire Raphaëlle , Diedisheim Marc , Julla Jean-Baptiste , Michieletto Jessica , Charbit Judith , Linden Daniel , Boucher Jeremie , Potier Charline , Hamimi Akila , Lemoine Sophie , Blugeon Corinne , Legoix Patricia , Lameiras Sonia , Baudrin Laura , Baulande Sylvain , Soprani Antoine , Castelli Florence , Fenaille Francois , Riveline Jean-Pierre , Rieusset Jennifer , Gautier Jean-François , Venteclef Nicolas , Alzaid Fawaz 
Published: May 2021

Abstract
Over the course of diet-induced obesity (DIO), adipose tissue macrophage (ATM) populations transition from highly oxidative and protective to highly inflammatory and metabolically deleterious. Here, we demonstrate that the Interferon Regulatory Factor (IRF)-5 is a key molecular switch mediating repression of macrophage oxidative capacity early in DIO. ATMs from mice with a myeloid-specific deletion of IRF5 are characterised by increased mitochondrial activity and oxidative respiration compared to ATMs from wild-type mice. This hyper-oxidative phenotype is inducible and reversible in vitro by delivery of an inhibitory IRF5-decoy peptide and through IRF5 adenoviral over-expression, respectively. In a data-driven approach, using public IRF5-cistrome data and in-house RNA-sequencing, we identified a transcriptional mechanism by which cellular oxidative capacity is repressed in an IRF5-dependent manner. The hyper-oxidative phenotype of IRF5-deficient macrophages is mediated by the Growth Hormone Inducible Transmembrane Protein (GHITM), known for maintaining mitochondrial architecture for optimal oxidative respiration. Cas9-mediated simultaneous knock-down of GHITM and of IRF5 reverses the hyper-oxidative phenotype associated with IRF5-deficiency in vitro. IRF5-dependent regulation of GHITM expression and mitochondrial activity extends to human ATMs and monocytes from obese and diabetic patients.
Making Assembly Line in Supply Chain Robust and Secure Using UHF RFID and Blockchain
Authors: Sharif Abu , Kumar Rajesh , Ouyang Jun , Abbas Hasan T. , Alomainy Akram , Arshad Kamran , Assaleh Khaled , Althuwayb Ayman , Imran Muhammad Ali , Abbasi Qammer H. 
Published: May 2021

Abstract
This paper presents a block-chain enabled inkjet-printed ultrahigh frequency radiofrequency identification (UHF RFID) system for the supply chain management, traceability and authentication of hard to tag bottled consumer products containing fluids such as water, oil, juice, and wine. In this context, we propose a novel low-cost, compact inkjet-printed UHF RFID tag antenna design for liquid bottles, with 2.5 m read range improvement over existing designs along with robust performance on different liquid bottle products. The tag antenna is based on a nested slot-based configuration that achieves good impedance matching around high permittivity surfaces. The tag was designed and optimized using the characteristic mode analysis. Moreover, the proposed RFID tag was commercially tested for tagging and billing of liquid bottle products in a conveyer belt and smart refrigerator for automatic billing applications. With the help of block-chain based product tracking and a mobile application, we demonstrate a real-time, secure and smart supply chain process in which items can be monitored using the proposed RFID technology. We believe the standalone system presented in this paper can be deployed to create smart contracts that benefit both the suppliers and consumers through the development of trust. Furthermore, the proposed system will paves the way towards authentic and contact-less delivery of food, drinks and medicine in recent Corona virus pandemic.
Surrogate Perspectives on a Patient Preference Predictor: Good Idea, But I Should Decide How It Is Used
Authors: Howard Dana , Rivlin Allan , Candilis Philip , Dickert Neal , Drolen Claire , Krohmal Benjamin , Pavlick Mark , Wendler David 
Published: May 2021

Abstract
Objective: Current practice frequently fails to provide care consistent with the preferences and values of decisionally-incapacitated, critically ill patients. It also imposes significant emotional burden on their surrogates. Algorithmic-based patient preference predictors (PPPs) have been proposed as a way to address these two concerns. While previous research found that patients strongly support the use of PPPs, the views of surrogates are unknown. This study assesses the views of experienced surrogates regarding the use of PPPs as a means to improve treatment decision making for incapacitated patients.Setting: Two academic medical centers and two community hospitals.Subjects: Experienced Surrogates [n=26].Interventions: An initial quantitative survey followed by an in-depth interview and a final quantitative survey.Measurements: Overall level of support for PPPs and views on how a PPP should be used, if at all, in practice.Main Results: Overall, 21 participants supported the use of PPPs. The remaining five indicated that they would not use a PPP because they made decisions based on the patient’s best interests, not based on which treatments the patient would choose for themselves. Some respondents expressed concern that PPPs might be used to deny expensive care or be biased against minority groups. Finally, 24 respondents indicated that surrogates, not patients, should decide how treatment decisions are made, including whether and how to use PPPs.Conclusions: Surrogates, like patients, strongly support the use of PPPs as a means to improving decision-making for incapacitated patients. These findings provide support for developing a PPP and assessing its use in practice. At the same time, patients and surrogates disagree over whose preferences should determine how treatment decisions, including whether to use a PPP, are made. These findings reveal a fundamental disagreement regarding the guiding principles for surrogate decision-making that need to be addressed by attempts to improve current critical care practice.
Impact of a restrictive antibiotic policy on the acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an endemic region: a quasi-experimental, before-and-after, propensity-matched cohort study in a Caribbean intensive care unit
Authors: Terrier Christophe Le , Vinetti Marco , Bonjean Paul , Richard Régine , Jarrige Bruno , Pons Bertrand , Madeux Benjamin , Piednoir Pascale , Ardisson Fanny , Elie Elain , Martino Frédéric , Valette Marc , Ollier Édouard , Breurec Sébastien , Carles Michel , Thiéry Guillaume 
Published: May 2021

Abstract
Background: High-level antibiotic consumption plays a critical role in the selection and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in ICU. Implementation of a stewardship program including a restrictive antibiotic policy was evaluated with respect to the ESBL-E acquisition (carriage and infection).Methods: We implemented a two-years, quasi-experimental, before-and-after intervention study with all consecutive adult patients admitted for >48 h in the medical-surgical 26-bed ICU of Guadeloupe University Hospital (French West Indies). A conventional strategy period (CSP), including a broad-spectrum antibiotic as initial empirical treatment, followed by de-escalation (period before) was compared to a restrictive strategy period (RSP) limiting broad-spectrum antibiotics and shortening their duration. Antibiotic therapy was delayed and initiated only after microbiological identification, except for septic shock, severe acute respiratory distress syndrome and meningitis (period after). A multivariate Cox proportional hazard regression model adjusted on propensity score values was performed. The main outcome was the median time of being free of ESBL-E in the ICU. Secondary outcome included all-cause ICU mortality.Results: The study included 1,541 patients, for a total of 738 in the CSP and 803 in the RSP. During the RSP, less patients were treated with antibiotics (46.8% vs 57.9%; p<0.01), treatment duration was shorter (5 vs 6 days; p<0.01), administration of antibiotics targeting anaerobic pathogens significantly decreased (65.3% vs 33.5%; p<0.01) compared to the CSP. The incidence of ICU-acquired ESBL-E was lower (12.1% vs 19%; p<0.01) during the RSP. The median time of being free of ESBL-E was 22 days (95% confidence interval, 16-NA days) in the RSP and 18 days (95% CI, 16-21 days) in the CSP. After propensity score weighting and adjusted analysis, the median time of being free of ESBL-E was independently associated with the RSP (hazard ratio, 0.746 [95% CI, 0.575-0.968]; p=0.02, and hazard ratio 0.751 [95% CI 0.578-0.977]; p=0.03, respectively). All-cause ICU mortality were lower in the RSP than in the CSP (22.5% vs 28.6%; p<0.01).Conclusions: Implementation of a program including a restrictive antibiotic strategy is feasible and is associated with less ESBL-E acquisition in the ICU without any worsening of patient outcome.
Arsenic in Mining Area: Environmental Contamination Route
Authors: Hott Rodrigo , Oliveira Grazielle , Bomfeti Cleide , Sousa Maicon , Santos Mayra , Andrade Thainá , Faria Márcia , Barbosa Fernando , Rodrigues Jairo Lisboa 
Published: May 2021

Abstract
The emission of residues has contributed immensely to the fact that man is susceptible and exposed to toxic chemical products, among them, arsenic. One of the main anthropic sources of arsenic in the world is mining, which can contribute to the contamination of soil, water, air, and food. An example of environmental arsenic contamination in Brazil occurs in the city of Paracatu - MG, due to the operation of a gold mine. Thus, the objectives of this study were: (i) to assess the physical-chemical parameters and the concentration of arsenic in samples of superficial fresh water (sub-basin of the Paracatu River), and soil samples, during winter and summer; (ii) evaluate the arsenic concentration in samples of particulate matter; (iii) determine the concentration and species of As in biological samples and (iiii) evaluate the toxicity of surface waters using the Allium cepa test. There was no change in the physical-chemical parameters. The water samples collected during the winter and all soil samples showed values ​​of As above those allowed by organs regulatory agencies. The values ​​of As in the particulate material showed great variations between the regions under study but were within the limit established by the ATSDR for urban areas. Inorganic and organic As was found above the limit allowed in biological samples The analysis of water toxicity by the Allium cepa test indicated the presence of cytotoxic and genotoxic compounds, demonstrating a great risk for the population exposed to the waters of the Rico stream.
UAV Cooperative Search in Dynamic Environment Based on Hybrid-Layered APF
Authors: Rui Shao , Tao Rentuo , Liu Youda , Yang Yuhao , Li Dasheng , Chen Jianjun 
Published: May 2021

Abstract
Unmanned Aerial Vehicle (UAV) detection has the advantages of flexible deployment, no casualties. It has become a force that cannot be ignored in the battlefield. Scientific and efficient mission planning can help improving the survival rate and mission completion rate of the UAV search in dynamic environments. Towards the mission planning problem of UAV collaborative search for multi-types of time-sensitive moving targets, a search algorithm based on hybrid layered artificial potential fields algorithm (HL-APF) was proposed. This paper utilized a new target attraction field function which was segmented by the search distance to quickly search for quickly targets searching. Moreover, in order to solve the problem of repeated search by the UAV in a short time interval, a search repulsion field generated by the UAV search path was proposed. Besides, in order to solve the unknown target search and improve the area coverage, a centralized layered scheduling algorithm controlled by the cloud server (CS) was added. CS divides the mission area into several sub-areas, and allocates UAV according to the priority function based on the search map. The CS activation mechanism can make full use of prior information, and the UAV assignment cool-down mechanism can avoid the repeated assignment of the same UAV. The simulation results show that compared with the hybrid artificial potential field and ant colony optimization (HAPF-ACO) and improved artificial potential field(IAPF), this method can significantly improve the found number of targets and mission area coverage. At the same time, comparative experiment results of CS mechanism proved the necessity of setting CS activation and cool-down for improving the search performance.
Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo-beta-lactamase-producing isolates
Authors: Matin Fatemeh Zanganeh , Rezatofighi Seyedeh Elham , Ardakani Mohammad Roayaei , Akhoond Mohammad Reza , Mahmoodi Fahimeh 
Published: May 2021

Abstract
BackgroundUropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infection (UTI); however, treatment of this disease has been associated with problems due to increased antimicrobial resistance (AMR). One of the most important types of AMR is carbapenem resistance (CR). CR bacteria are known as an important challenge to global public health today. Class B metallo-beta-lactamases (MBLs) are one of the major factors for resistance against carbapenems. We aimed to investigate the characteristics of UPEC isolates producing MBL. MethodsA cross-sectional study was conducted from October 2018 to December 2019 in Ahvaz; Iran. Urine samples of patients with UTI were collected and UPEC isolates were identified by biochemical and molecular methods. Metallo-beta-lactamase-producing isolates were detected using modified carbapenem inactivation method (mCIM) and EDTA-CIM (eCIM) tests. MBL genes, phylogenetic group, and virulence genes profile of carbapenem resistant isolates were determined. Conjugation assay and plasmid profiling were conducted to evaluate the ability of transferring of CR to other E. coli isolates. Clonal similarity of isolates were assessed using Enterobacterial intergenic repetitive element sequence (ERIC)-PCR. ResultsAmong 406 UPEC isolates, 12 (2.95%) carbapenem-resistant were detected of which 11 were phenotypically MBL-producing. Four isolates were resistant to all antimicrobial agents and were considered possible pandrug-resistant (PDR). blaNDM, blaOXA-48, blaIMP-1, and blaIMP-2 genes were found in 9, 5, 1, and 1 isolates, respectively. Among 30 virulence genes investigated, the traT, fyuA followed by fimH, and iutA with the frequency of 8 (66.7%), 8 (66.7%), 7 (58.3%), and 7 (58.3%) were the most identified genes, respectively. Siderophore production was the main virulence trait among carbapenem-resistant UPEC isolates. Except for two, all other isolates showed weak to moderate virulence index. In all recovered isolates, CR was readily transmitted via plasmids to other isolates during conjugation experiments. ConclusionMBL and carbapenemase genes, especially blaNDM and blaOXA-48 are spreading rapidly among bacteria, which can be a threat to global public health. Therefore monitoring the emergence and dissemination of new AMR is necessary to continuously refine guidelines for empiric antimicrobial therapy. Understanding the mechanisms of resistance and virulence in this group of bacteria can play an effective role in providing new therapeutic methods.
The Hydrodynamic Cavitation Manifestation in Small Chips
Authors: Ghorbani Morteza 
Published: May 2021

Abstract
Cavitation is a phase change phenomenon created by the static pressure reduction of a liquid medium at a constant temperature. This process has been considered as a disadvantageous mechanism in most turbomachinery systems, however, its potential in releasing energy at the bubble collapse stage has received lots of attention in recent decades. Particularly, the applicability of this phenomenon in micro scale gives rise to the research studies in different fields, i.e., wastewater treatment and medical imaging. In this study, microfluidic devices housing small microchannels have been fabricated to study the generation of the cavitating flow patterns bubbles. The main focuses in this work are on the surface and side wall roughness together with the size reduction effects on cavitation bubble generation. Accordingly, the microfluidic devices were fabricated using the techniques adopted from semi conductor based micro-fabrication. The experiments were performed at relatively higher upstream pressure, 4 to 7 MPa, to investigate the durability of the devices and flow patterns features. The results show that the side wall roughness elements are very effective in the small microchannels in terms of facile cavitating flow generation, while the size reduction in the diameter of the channel does not accompany intensified cavitating flow necessarily.