bluuebunny/crossref_metadata_2025_split huggingface dataset:
PPARdelta in Affected Atopic Dermatitis and Psoriasis: A Possible Role in Metabolic Reprograming
Authors: Blunder Stefan , Pavel Petra , Minzaghi Deborah , Dubrac Sandrine 
Published: July 2021

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors expressed in the skin. Three PPAR isotypes, α (NRC1C1), β or δ (NRC1C2) and γ (NRC1C3), have been identified. After activation through ligand binding, PPARs heterodimerize with the 9-cis-retinoic acid receptor (RXR), another nuclear hormone receptor, to bind to specific PPAR-responsive elements in regulatory regions of target genes mainly involved in organogenesis, cell proliferation, cell differentiation, inflammation and metabolism of lipids or carbohydrates. Endogenous PPAR ligands are fatty acids and fatty acid metabolites. In past years, much emphasis has been given to PPARα and γ in skin diseases. PPARβ/δ is the least studied PPAR family member in the skin despite its key role in several important pathways regulating inflammation, keratinocyte proliferation and differentiation, metabolism and the oxidative stress response. This review focuses on the role of PPARβ/δ in keratinocytes and its involvement in psoriasis and atopic dermatitis. Moreover, the relevance of targeting PPARβ/δ to alleviate skin inflammation is discussed.
Efficiency Analysis of the Turbine using Calorific Value Parameters for a 10 Megawatt Gas Turbine
Authors: Amadi Rex K.C , David Charles 
Published: July 2021

This research is based on the thermodynamic performance of a gas turbine power plant. It considered the variation of operating conditions, i.e. the ambient temperature, the compressor outlet temperature, pressure ratio, etc. on the performance of the gas turbine thermal efficiency, turbine work, compressor work, etc. which were derived and analyzed. The Gross (higher) calorific values at constant pressure () heat of combustion in a flow process from state 1 to state 2 was considered and used to analyze our thermal efficiency. The results show that the ambient temperature and air to fuel ratio strongly influence the turbine work, compressor work and thermal efficiency. In addition, the thermal efficiency and power decreases linearly with increase of the ambient temperature. However, the efficiency analyzed when the calorific parameters were considered was higher than the efficiency when the basic thermodynamic theories (first and second law principles) were used. The first ranges between 31% to 33, while the second ranges between 28% to 32% under the same ambient temperature conditions
Determination – the universal language of self-awareness of a subject of law enforcement agencies
Authors: Sharanov Yuriy , Ustyuzhanin Viktor 
Published: July 2021

Nowadays the problem of consciousness and self-awareness is experiencing a revival in a psychological science. Active efforts are being made in this sphere to break «the psychological stalemate» of inertia of the old methodological guidelines which consider consciousness and self-awareness as simple functions of the objective reality reflection and reproduction. Numerous researches of national and international scientists, different scientific conferences are dedicated to the analysis of these guidelines.
Our concept of determination is a logical follow-up to L. S. Vigotsky’s ideas as it reflects the emergence and development of the phenomenon of significance in the human mind, postulates that consciousness and self-awareness are called upon to perform one common function of determination (self-determination). The choice of determination as the subject of this research is made because of the changes in the field of psychological knowledge. This involves the shift away from the classical science towards the non-classical one and, in the recent years, towards the postclassical explanatory paradigm in psychology. These nonclassical ideas can be found in theoretical considerations of Vigotsky whose attention was occupied with the actual state of psychological mind when the issues of determinism were traditionally regarded only in biological and physiological factors and mechanisms - in the so-called objective methods of consciousness while determinants posed by the human psyche itself were ignored.
Postclassical view of the world and understanding of the human place in it went a step further, it is focused today on the reflection of value and sense contexts of a person. As a request for dialogism, expression discursivity of ideas, thoughts, opinions mounted, there is a need for subjective paradigm. Psychologists in this process seek to go beyond the narrow frames of determination of a subject’s activeness limited only with his «activity» and turn to the notion «existence». In other words they attempt to move from being to formation, ongoing development of a subject’s psyche.
The history of the formation and legislative registration of the activities of the Nizhny Novgorod Fair Police
Authors: Akhmedov Chingiz 
Published: July 2021

In this article, the author examines the history of the formation of the Nizhny Novgorod fair police from the beginning of the XIX century. The reasons for its establishment are found out, from the fact that due to the lack of a sufficient number of police officers of the Nizhny Novgorod province, their functions during the fairs were performed by temporarily assigned Cossack formations from the military department, which did not have a sufficient level of competence in the implementation of law enforcement activities.
The author consistently reveals the interest of the provincial authorities in the protection of law and order during fairs and their interaction with the leadership of the Ministry of Internal Affairs when creating a commission for the formation of police constables on the basis of archival and literary sources. The article examines the activities of the commission for financing the police constables, providing them with weapons and means of movement. On the basis of the instruction, the rights and obligations of the mounted police constables, who ensure the protection of public order during the fairs, were analyzed. The author emphasizes that, despite the temporary nature of the formation of police constables, they were assigned the same duties and enjoyed the same rights as the ranks of the district police.
Ensuring road safety: the main stages of institutionalization in Russia
Authors: Kvitchuk Anatoly 
Published: July 2021

The article is devoted to the historical and legal study of the development and formation of the road safety system, the regularity of its development, legal regulation, especially during the period of motorization of the Russian Empire, and then the Soviet Republic, when the legislator set the tasks of ensuring road safety in a concrete form. Their consolidation in normative legal acts was of a casual nature, for example: avoid riding horses and bicycles on sidewalks; observe that painters with tubs, buckets and other accessories, hand carts and sleds, do not walk on the sidewalks, but follow the roads, obeying the general order of traffic on the street; not allowed to play balls, and similar games in the street in front of the houses, to fly kites, to wear uncovered mirrors so as not to frighten horses, to clutter the sidewalks with barrels, tar boxes, and firewood, and to prevent peddlers and merchants from blocking the free passage on the bridge and the passage on the sidewalk with their trays.
The international experience of traffic regulation was used. Special attention was paid to the training of the driver’s staff. The propaganda of road safety of the Soviet society was widely introduced in all spheres of life, and then became part of the ideological education of the Soviet person. New «Traffic rules on the streets of cities, settlements and roads of the USSR» were approved. The State Traffic Inspectorate was reformed and new technologies were introduced into its activities, control and supervision of traffic was improved with the use of technical means and innovative technologies, which certainly affected a significant reduction in accidents in Russia.
Parliamentary discourse on the pages of regional periodicals as a determinant of the formation of public consciousness in Russia at the beginning of the 20-th century
Authors: Sidorenko Nadezhda , Nizhnik Nadezhda 
Published: July 2021

The relevance of the study of problems relating to the organization and activities of representative bodies in democratic States is not diminished. The media play an important role in increasing public confidence in Parliament and in parliamentarians, and their activities are a determining factor in shaping the image of the legislature in the public consciousness. In the context of the forthcoming elections of deputies to the State Duma of the Federal Assembly of the Russian Federation in 2021, the experience of the media in covering the work of the Russian Parliament, including the experience gained during the years of activity of the State Duma of the Russian Empire, is of particular interest. The subject of the study is the parliamentary discourse on the pages of the periodical press of the Urals, which is a determinant of the formation of public consciousness during the years of the convening and activity of the State Duma of the Russian Empire. The methodology of the study is determined taking into account the concept of T. A. van Dyke on the processing of language in the context of social factors. Understanding the discourse as a text interpreted by the author in accordance with his political position in a specific communicative situation, the authors made an attempt to analyse the texts placed on the pages of the periodicals of the largest region of Russia - the Urals, concerning the convening of the State Duma of the Russian Empire and the practice of the Russian parliament in 1906-1917. Parliamentary discourse is a manifestation of political communication and communication between political actors, including the population of the Russian Empire, who received electoral rights in 1905.
The cognitive model for analyzing parliamentary discourse takes into account the identity of the transmitting entity (addressee), the message itself, the receiving entity (addressee). An analysis of parliamentary discourse provides an opportunity to identify a mechanism for influencing the public’s perception of the rule of law, the appointment and the effectiveness of parliamentary action.
Infliction of harm under the conditions of necessary defense. Criminal law doctrine and problems of qualification
Authors: Malkin Vladislav 
Published: July 2021

The article deals with different points of view that have developed in the criminal law doctrine on the problem of qualifying the infliction of harm in conditions of necessary defense. The author presents his own analysis of the legal rules that form the institution of necessary defense.
Application of rules on necessary defense is a topical theoretical and practical problem. In the theory of criminal law there is a different understanding of the legality and unlawfulness of causing harm in conditions of necessary defense. Using examples of law enforcement practice, as well as relying on the opinions of various legal scholars, the author systematizes the conditions for the legitimacy of necessary defense into two groups: 1) conditions for the emergence of the right to necessary defense, which, in their entirety, constitute its basis; 2) conditions that determine the limits of permissible protection, violation of which is qualified as exceeding the limits of necessary defense.
The author proposes to consider the infliction of harm in conditions of necessary defense on the basis of the principles of proportionality and necessity, and qualify the act under consideration as exceeding the limits of necessary defense only in the case of violation of both principles. The analysis carried out in the article highlighted the need for some changes and additions to the regulatory legal acts.
Mengembangkan Keterampilan Sosial Siswa MI/SD
Authors: Syamsudin Syamsudin 
Published: July 2021

Pembelajaran IPA diarahkan untuk mencari tahu dan berbuat sehingga dapat membantu peserta didik memperoleh pemahaman yang lebih mendalam tentang alam sekitar. Selain itu pribadi siswa sebagai makhluk sosial perlu dilatih agar memiliki keterampilan sosial yang tinggi demi pencapaian tujuan pembelajaran. Keterampilan sosial merupakan kemampuan individu dalam bentuk perilaku yang mendukung kesuksesan hubungan sosial dan membantu seseorang menyesuaikan diri serta memungkinkan individu untuk bekerja bersama dengan orang lain secara efektif. Salah satu model pembelajaran yang efektif untuk mengembangkan keterampilan sosial adalah model pembelajaran kooperatif tipe Student Teams Achievement Division (STAD). Dalam model pembelajaran kooperatif tipe STAD skor kemajuan individu dan kelompok akan sangat berpengaruh terhadap prestasi kelompok. Gagasan utama di belakang STAD adalah memacu siswa agar saling mendorong dan membantu satu sama lain untuk menguasai keterampilan yang diajarkan guru. Hal ini akan membuat siswa menjadi semangat untuk belajar agar mampu menambah poin kelompok dan membantu teman sekelompok jika belum menguasai bahan yang diajarkan oleh guru. Apabila setiap hari mereka melakukan hal ini maka akan terbentuk keterampilan sosial yang bagus.
Kata kunci: Pembelajaran IPA, Model Pembelajaran Kooperatif Tipe STAD, Keterampilan Sosial
PARENTING SKILL DI DESA SUKAHARJA KECAMATAN TELUK JAMBE TIMUR
Authors: Wina Lova Riza  
Published: July 2021

Selama tahun-tahun pertama kehidupan merupakan periode yang unik bagi perkembangan manusia. Untuk memastikan hasil yang terbaik bagi perkembangan anak, orang tua menghadapi tantangan untuk menyeimbangkan kasih sayang dan tuntutan disiplin agar dapat mengoptimalkan kemampuan dan keberfungsian anak. Mengembangkan pola asuh yang sesuai selama tahun-tahun pertama kehidupan seorang anak merupakan hal yang menantang terutama bagi orang tua baru atau bagi orang tua yang bekerja. Maka perlu diadakan pengabdian tentang pola asuh agar dapat memberikan edukasi kepada orang tua menuju keseimbangan dalam mendidikan dan membesarkan anak. Program kegiatan ini berupa pengisian data kuesioner potensi dan perkembangan desa terkait profil desa berkelanjutan. Narasumber untuk pengisian kuesioner ini adalah dosen psikologi dan memaparkan materi tentang pola asuh dari sudut pandang psikologi. Peserta pengabdian ini adalah orang tua di Desa Sukaharja dan untuk membantu orang tua terutama orang tua baru untuk dapat menerapkan pola asuh yang baik pada anak agar anak dapat perkembangan anak menjadi optimal.
Kata kunci: parenting skill, anak, orang tua
During the first years of life is a unique period for human development. To ensure the best possible outcome for their child's development, parents face the challenge of balancing love and discipline in order to optimize children's abilities and functioning. Developing appropriate parenting during the first years of a child's life can be especially challenging for new parents or working parents. So it is necessary to hold service about parenting in order to provide education to parents towards balance in educating and raising children. This activity program is in the form of filling out questionnaire data on village potential and development related to sustainable village profiles. The resource person for filling out this questionnaire was a psychology lecturer and explained material about parenting from a psychological perspective. Participants of this service are parents in Sukaharja Village and to help parents, especially new parents, to be able to apply good parenting to their children so that their child can develop optimally.
Keywords: parenting skill, child, parent
SOSIALISASI PERAN KELUARGA SEBAGAI PONDASI PENGUATAN MOTIVASI BELAJAR SISWA DI TENGAH PANDEMI COVID-19
Authors: Lusiana Rahmatiani  , Sri Wulan Anggraeni  
Published: July 2021

Kegiatan pengabdian masyarakat ini memiliki tujuan untuk memberikan sosialisasi peran keluarga sebagai pondasi penguatan motivasi belajar siswa di tengah pandemi Covid-19 pada masyarakat desa jatisari kabupaten karawang. Metode yang digunakan dalam mencapai tujuan pelaksanaan kegiatan pengabdian yang dilaksanakan di tengah pandemi covid-19 ini melalui ceramah dan tanya jawab dengan pertemuan melalui zoom meeting. Pelaksanaan pengabdian dilaksanakan pada bulan Agustus 2020. Hadirnya sosialisasi peran keluarga sebagai pondasi penguatan motivasi belajar siswa ditengah pandemi Covid-19 diharapkan mampu memberikan edukasi kepada masyarakat mengenai pentingnya peran keluarga sebagai pondasi penguatan motivasi belajar siswa sehingga meminimalisir penurunan motivasi siswa dalam belajar dirumah, pelaksanaan pembelajaran dapat dilakukan melalui metode dan media sosial yang mendukung termotivasinya siswa dalam belajar, juga pentingnya peran keluarga dalam memberikan pemahaman kepada anak mengenai bahaya kesehatan dari covid-19. Dengan demikian diharapkan tumbuhnya pemahaman peran keluarga dalam penguatan motivasi siswa belajar dirumah selama masa pandemi covid-19 dengan tetap menjaga kesehatan sesuai anjuran dari pemerintah untuk tetap mengedepankan protokol kesehatan dalam pembelajaran dirumah, karena sehat menjadi kunci utama dalam belajar.
Kata Kunci: Peran Keluarga, Motivasi Belajar.
This community service activity aims to provide socialization on the role of the family as a foundation for strengthening student motivation in the Covid-19 pandemic in the village community of Jatisari, Karawang district. The method used in achieving the implementation of service activities carried out in the Covid-19 pandemic is through lectures and questions and answers with meetings through zoom meetings. The implementation of the service was carried out in August 2020. The socialization of the role of the family as a foundation for strengthening student motivation in the Covid-19 pandemic is expected to be able to provide education to the community about the importance of the role of the

family as a foundation for strengthening student learning motivation to minimize the decrease in student motivation in learning at home, implementing learning This can be done through methods and social media that support student motivation in learning, as well as the importance of the role of the family in providing understanding to children about the health dangers of Covid-19. Thus it is hoped that the understanding of the role of the family in the motivation of students who study at home during the Covid-19 pandemic will grow while maintaining health according to recommendations from the government to continue to prioritize health protocols in learning at home, because being healthy is the main key in learning.
Keywords: Family Role, Learning Motivation
Analyzing Heart Disease Mortality of Filipino: From Statistical Modeling to Health and Lifestyle Education Implications
Authors: Deguma Jabin J. , Peteros Emerson D. , Capuno Reylan G. , Ybañez Ricardo Q. , Cebe Danilo F. , Revalde Helen O. , Sitoy Regina E. , Deguma Melona C. 
Published: July 2021

This paper contributes an interdisciplinary cross-over in studying heart disease mortality of Filipino. First, it validates previous studies on heart diseases via ascertaining statistical models of analyses that estimate heart disease mortality predictability in the Philippines. It then proceeds to understand the implications of the issue through promoting health and lifestyle education. To do this, first, the report from the Epidemiology Bureau of the Department of Health (EBDOH) on mortality cases of diseases of the heart in the Philippines. Based on the statistical analyses, time series analysis suggested that the growth of heart disease mortality in the Philippines followed a quadratic trend. Moreover, symbolic regression (SR) analysis revealed that heredity has more significant influence over lifestyle between the identified factors. Based on the proposed models, this paper implies furthering community-oriented health and wellness programs as practical means to avoid untimely deaths brought by the said diseases.

Received: 4 March 2021 / Accepted: 6 May 2021 / Published: 8 July 2021
Has Albania's Economic Development Stalled? Investigating the Role of Institutional Factors in Albania's Economic Performance
Authors: Osmani Myslym , Kodra Kledi , Salko Drini 
Published: July 2021

This study focuses on the institutional factors of Albania's economic development, from a comparative, dynamic, and regional European perspective. We use longitudinal data for the years 2002, 2014, and 2019 and a small selection of 13 countries in the region and some EU member states. Descriptive statistics, graphical representation, and econometric modeling are used for data analysis. The purpose of the study is to discuss, in real and comparative terms with the region and beyond, the economic growth of Albania based on the GDP per capita indicator, as well as to identify and evaluate dynamically the role of institutions in the country's development through important institutional factors, such as the effectiveness of government, rule of law, corruption, etc. The analysis shows that Albania's economic performance is weakover the last two decades. This is reflected in the insufficient relative growth of GDP per capita, the small increase in per capita income, and especially in the low increase in income for every 1% of relative growth. In these indicators, Albania continues to be consistently in the lowest positions in the region and beyond. The study highlights the strong link between economic growth and the effectiveness of government, the rule of law, and weak control over corruption. Improving corruption control by one unit in the range (-2.5 to 2.5) is expected to improve GDP per capita by an average of about 2.2 times. Improving the rule of law by one point is expected to improve GDP per capita on average by about 2.4 times. The country's sluggish economic performance is mainly attributed to weak institutions.

Received: 4 March 2021 / Accepted: 6 May 2021 / Published: 8 July 2021
Assessment of Applying Saudi Labour Law to Digital Platform Workers: Taking Uber as an Example
Authors: Alharbi Meshal Nayef 
Published: July 2021

The use of technology platforms has become quite common and popular worldwide. Some of these platforms have used for business purpose such as connecting taxi drivers with riders or providing delivery services. At present, there are famous institutions employing persons to provide their services through digital platforms, and in some states, such persons are considered workers. In the Kingdom of Saudi Arabia, it is significant to find a direct answer to whether or not persons using digital labour platforms to offer services could be regarded as workers, and the Saudi Labour Law must, or not, be applied to govern their contracts with the enterprises that own these platforms. This paper aims to find a legal solution to this issue and concentrates on digital platform workers in Saudi Arabia. It examines mainly legal sources relating to Saudi Labour Law such as books, and investigates a number of reported judgments issued by the Commission for the Settlement of Labour Disputes in Saudi Arabia in 2010 and 2011.It also reviews relative information provided on the web sites of Uber. The finding is that the traditional rules of Saudi Labour Law should apply to these types of work agreements, and persons rendering their services through digital platforms must be protected by the rules established in the Law, but, according to the recent provisions adopted by the Saudi Ministry of Human Resources and Social Development, it seems that they are considered as freelancers.

Received: 4 March 2021 / Accepted: 6 May 2021 / Published: 8 July 2021