bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvability of the abstract evolution equations in L

s
-spaces with critical temporal weights
Authors: Zhang Qinghua , Tan Zhizhong 
Published: April 2021

Abstract
This paper deals with the abstract evolution equations in

L

s

{L}^{s}

-spaces with critical temporal weights. First, embedding and interpolation properties of the critical

L

s

{L}^{s}

-spaces with different exponents

s

s

are investigated, then solvability of the linear evolution equation, attached to which the inhomogeneous term

f

f

and its average

Φ
f

\Phi f

both lie in an

L

1

/

s

s

{L}_{1\hspace{-0.08em}\text{/}\hspace{-0.08em}s}^{s}

-space, is established. Based on these results, Cauchy problem of the semi-linear evolution equation is treated, where the nonlinear operator

F

(

t
,
u

)

F\left(t,u)

has a growth number

ρ
≥
s
+
1

\rho \ge s+1

, and its asymptotic behavior acts like

α

(

t

)

/

t

\alpha \left(t)\hspace{-0.1em}\text{/}\hspace{-0.1em}t

as

t
→
0

t\to 0

for some bounded function

α

(

t

)

\alpha \left(t)

like

(

−
log
t

)

−
p

{\left(-\log t)}^{-p}

with

2
≤
p
<
∞

2\le p\lt \infty

.
An Investigation of Science Teachers’ Web Pedagogical Content Knowledge / Istraživanje poznavanja mrežnoga pedagoškog sadržaja nastavnika prirodnih predmeta
Authors: Balcı Abdullah , Aydoğdu Bülent , Özdinç Fatih 
Published: April 2021

The purpose of this study was to investigate the web pedagogical content knowledge of science teachers. As a mixed method design, this study was carried out with science teachers. A total of 229 science teachers participated in the quantitative part of the study and 17 science teachers with different year experience took part in the qualitative part. Quantitative data in the study were collected through the Web Pedagogical Content Knowledge Scale and the qualitative data were collected by a semi-structured interview. The obtained quantitative data were analyzed using descriptive statistics, Mann-Whitney U test and Kruskal-Wallis H test. The content analysis was used on the qualitative data. The quantitative results of the research indicated that the levels of teachers’ self-efficacy perceptions regarding web pedagogical content knowledge were very high. Moreover, the scores obtained from the overall scale and its sub-dimensions significantly differed with regards to work experience of science teachers. The qualitative findings of the study revealed that science teachers made use of the Web for lectures, experiments, practice, visual support, videos, and compensating the lack of materials. It was also emphasized that teachers should be educated to use the Web in their teaching practices.Key words: science teachers; web-based teaching; web pedagogical content knowledge; self-efficacy. --- Cilj ovoga istraživanja bio je ispitati poznavanje mrežnoga pedagoškog sadržaja nastavnika prirodnih predmeta. Istraživanje je zasnovano na dizajnu miješanih metoda i provedeno je s uzorkom nastavnika prirodnih predmeta, koji je obuhvatio ukupno 229 nastavnika u kvalitativnom dijelu studije i 17 nastavnika prirodnih predmeta, s različitim iskustvom, u kvalitativnom dijelu istraživanja. Kvantitativni podatci u istraživanju sakupljeni su upotrebom Skale poznavanja mrežnoga pedagoškog sadržaja, a kvalitativni podatci sakupljeni su polustrukturiranim intervjuom. Deskriptivne statistika, Mann-Whitney U test i Kruskal-Wallis H test upotrijebljeni su za analizu kvantitativnih podataka, a metodom analize sadržaja obrađeni su kvalitativni podatci. Kvantitativni rezultati istraživanja pokazuju vrlo visoke razine percepcije samoučinkovitosti vezane za poznavanje mrežnoga pedagoškog sadržaja nastavnika prirodnih predmeta. Osim toga, rezultati dobiveni primjenom sveukupne Skale i njezinih poddimenzija značajno se razlikuju s obzirom na iskustvo nastavnika. Kvalitativni rezultati studije otkrili su da nastavnici prirodnih predmeta koriste mrežu za predavanja, eksperimente, praksu, vizualnu podršku, videozapise i kompenzaciju manjka materijala. Također je naglašeno da nastavnici trebaju biti obrazovani kako bi koristili mrežu u svojim praksama poučavanja.Ključne riječi: nastavnici prirodnih predmeta, mrežno potpomognuto poučavanje; poznavanje mrežnoga pedagoškog sadržaja; samoučinkovitost.
Different Perspectives on Success in Solving Stand-Alone Problems by 14 to 15-Year-Old Students / Različite prespektive o uspješnosti 14 i 15-godišnjaka u rješavanju izoliranoga problema
Authors: Baranović Nives , Antunović-Piton Branka 
Published: April 2021

The paper defines a special type of problem tasks and considers its didactic potential, as well as the success of students in solving the selected problem. The research instrument used is a geometrical task from the National Secondary School Leaving Exam in Croatia (State Matura). The geometrical task is presented in three versions: as a verbal problem, as a verbal problem with a corresponding image and as a problem in context. The material analysed in the present paper was collected from 182 students in 7th and 8th grade of Croatian urban elementary schools. The didactic potential is considered from the aspect of use of mathematical concepts and connections. The success of students in problem-solving is considered from the aspect of implementation of the problem-solving process and producing correct answers, depending on the manner in which the tasks are set up. The results show that the stand-alone problem, as a special type of problem task, has considerable didactic potential. However, the students’ skills of discovering and connecting mathematical concepts and their properties are underdeveloped. In addition, the manner in which the tasks are set up considerably affects the process of solving the task and consequently the success of that process. Based on the results of the research, proposals are given for application of stand-alone problems in teaching mathematics.Key words: isolated problem; mathematical task; problem solving; problem evaluation. --- U radu se definira posebna vrsta problemskoga zadatka te se razmatra njegov didaktički potencijal kao i uspješnost učenika u rješavanju odabranoga problema. Instrument istraživanja je geometrijski zadatak s državne mature koji se postavlja u tri inačice: kao tekstualni problem, kao tekstualni problem uz odgovarajuću sliku te kao zadatak u kontekstu. U istraživanju je sudjelovalo 182 učenika 7. i 8. razreda hrvatskih gradskih osnovnih škola. Didaktički potencijal razmatra se s aspekta iskoristivosti matematičkih koncepata i veza, a uspješnost učenika u rješavanju problema razmatra se s aspekta provedbe procesa rješavanja i otkrivanja točnoga rješenja ovisno o načinu postavljanja zadatka. Rezultati pokazuju da promatrani problem kao posebna vrsta problemskoga zadatka ima veliki didaktički potencijal, ali da učenici imaju nedovoljno razvijene vještine otkrivanja i povezivanja matematičkih koncepata i njihovih svojstava. Osim toga, način postavljanja zadatka značajno utječe na proces rješavanja, a posljedično i na uspješnost određivanja rješenja. Na temelju rezultata daju se prijedlozi primjene opisane vrste problema u nastavi Matematike.Ključne riječi: izolirani problem; matematički zadatak; rješavanje problema; vrednovanje problema
Music Therapy in Educating Children with Developmental Disabilities / Muzikoterapija u procesu obrazovanja djece s teškoćama u razvoju
Authors: Katušić Ana , Burić Ksenija 
Published: April 2021

Music therapy acts as a separate discipline in the interdisciplinary field of science and art. Unlike music education, music therapy is aimed at developing and enhancing non-musical skills by using music as a symbol of emotional and personal growth. The purpose of this paper is to present an overview of the theoretical foundations of music therapy in the field of human psychology and music pedagogy, as well as the development of music therapy models that have arisen from these theoretical approaches. The most commonly used music therapy models in special education are based on improvisational music therapy techniques, which include free improvisation therapy, creative music therapy known as the Nordoff-Robbins model, and Orff music therapy. Improvisation in these models plays a key role during the acquisition and promotion of skills. Using sounds, playing instruments, making music here and now, allows for expression and exploration, and enables children to acquire skills in different developmental domains. Finally, the paper offers an overview of the use of music therapy in education of children with developmental disabilities educating developmentally disabled children, its unique features and connections with the education through music approach, in accordance with the set-up goals of the Individual Education Plan.Key words: Individual Education Plan; music therapy; improvisational models; education; children with developmental disabilities. --- Muzikoterapija djeluje kao zasebna disciplina u interdisiciplinarnom području znanosti i umjetnosti. Za razliku od glazbenoga obrazovanja, muzikoterapija je usmjerena prema razvoju i jačanju neglazbenih vještina koristeći glazbu kao simbol emocionalnoga i osobnoga rasta. Svrha je ovoga rada prikazati pregled teorijskih osnova muzikoterapije na području humanističke psihologije i glazbene pedagogije, kao i razvoj modela muzikoterapije koji su proizašli iz navedenih teorijskih pravaca. Modeli muzikoterapije koji se najčešće koriste u procesu obrazovanja djece s teškoćama u razvoju zasnivaju se na improvizacijskim tehnikama muzikoterapije, a obuhvaćaju: terapiju slobodnom improvizacijom, kreativnu muzikoterapiju poznata kao Nordoff-Robbins model i Orff muzikoterapiju. Improvizacija u ovim modelima ima ključnu ulogu tijekom usvajanja i poticanja vještina. Korištenje zvukova, sviranje instrumenata, stvaranje glazbe ovdje i sada, omogućava izražavanje i istraživanje, a djeci pruža mogućnost samoostvarenja na različitim razvojnim područjima. Naposljetku u radu se nudi prikaz primjene muzikoterapije u obrazovanju djece s teškoćama u razvoju, njegove jedinstvenosti te poveznice u odnosu na pristup obrazovanja kroz glazbu sukladno postavljenim ciljevima Individualnog edukacijskog plana.Ključne riječi: Individualni edukacijski plan; muzikoterapija; improvizacijski modeli; obrazovanje; djeca s teškoćama u razvoju
Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia–pyometra
Authors: Gültiken Nilgün , Yarim Murat , Yarim Gül Fatma , Sözmen Mahmut , Anadol Elvan , Findik Murat 
Published: April 2021

AbstractThe objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)–pyometra complex. Group 1 (n = 10) included bitches with open cervix pyometra, while Group 2 (n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. IGF-2 immunopositivity was observed in the endometrial glandular epithelium in both groups. Additionally, interstitial fibroblasts and macrophages in the endometrium were also positive in Group 1. The concentration of plasma IGF-2 was higher in Group 1 than in Group 2 (P < 0.05). The concentration was positively correlated with IGF-2 expression in the endometrial glands (r = 0.926; P < 0.001) in Group 1. However, a negative correlation was present between plasma IGF-2 concentration and IGF-2 expression in the interstitial endocrine cells of the ovary in Group 1 (r = −0.652; P < 0.05). The results suggest that IGF-2 plays an important role during the inflammatory process occurring in bitches with CEH–pyometra complex as well as in the endometrium of healthy bitches in dioestrus.
Motor neurorehabilitation in patients with epileptic seizures: limitations of methods with proven efficacy in stroke
Authors: Lyukmanov R. Kh. , Rimkevichus A. A. , Shalimanova E. V. , Voronkova K. V. , Suponeva N. A. , Piradov М. А. 
Published: April 2021

Patients with epilepsy may require a neurorehabilitation aid particularly due to developing motor alterations related to stroke, sequelae of traumatic brain injury, multiple sclerosis and other brain damage. Modern neurorehabilitation approaches directly or indirectly affect neuroplastic processes altering cerebral cortex excitability, stimulate the afferentation systems, and result in fatigue and may act as factors provoking seizures or aggravated epilepsy. In addition, developing seizures may temporarily coincide but unrelated to the neurorehabilitation activities: e.g., while omitting antiepileptic drug administration, sleep deprivation or long-term stress occurring to patient etc. Here we present a review on recent studies aimed at investigating epilepsy triggers by aligning them with the factors of interventions used in motor rehabilitation. We also emphasize the safety data for routine use of the main neurorehabilitation methods as well as propose actions to reduce the risk of developing epileptic seizure.
Problems of diagnosing focal cortical dysplasia
Authors: Yakovleva K. D. , Kantemirova E. A. , Dmitrenko D. V. 
Published: April 2021

Focal cortical dysplasia (FCD) is one of the most common causes in developing pharmacoresistant epilepsy. We present the clinical case of the patient with generalized seizures. Routine electroencephalography (EEG) data registered diffuse epileptiform activity that allowed to diagnose genetic eneralized epilepsy and pharmacoresistant course of seizures.After performing magnetic resonance imaging using the epileptological program and video-EEG-monitoring, the diagnosis was revised: structural focal epilepsy with seizures with focal onset with oroalimentary, gesture automatisms in the right hand, bilateral tonic-clonic, uncompensated by levetiracetam monotherapy (1500 mg/day). Background disease: congenital malformation of the brain: FCD in the basal parts of the left temporal lobe. Lacosamide was added to the therapy in the drug dose 300 mg/day, and the frequency of epileptic seizures decreased. Differential diagnosis between genetic generalized epilepsy and structural epilepsy with FCD usually poses no obstacles. However, in some cases, structural epilepsy occurs under the “mask” of generalized epilepsy. Hence, this clinical case demonstrates the importance of diagnostic measures in the differential diagnostics of various forms of epilepsy to determine further tactics of patient management.
Clinical case of epilepsy, hearing loss and mental retardation syndrome associated with mutations in SPATA5 gene
Authors: Kozhanova T. V. , Zhilina S. S. , Meshcheryakova T. I. , Luk’yanova E. G. , Osipova K. V. , Ayvazyan S. O. , Prityko A. G. , Zavadenko N. N. 
Published: April 2021

We present the clinical case of patient with epilepsy, developmental retardation and hearing loss. The whole exome sequencing allowed to reveal compound heterozygous variants of the nucleotide sequence in SPATA5 gene (c.1714+1G>A, c.1678G>A). Mutations in the SPATA5 gene have been described in patients with epilepsy, hearing loss and mental retardation syndrome (MIM 616577). Paired parents were carriers of one heterozygous gene variant. Such mutations lead to the development of epileptic disorders in 3% of cases, and should be considered in patients not only as a possible cause of neurodegenerative diseases, but also leading to pathology with clinical manifestations mimicking mitochondrial disease.
Utilização do ZEBMAX® para aumento de produtividade na alface
Authors: Zullo Godinho Emmanuel , Gasparotto Hélio Vagner , De Lima Caneppele Fernando 
Published: April 2021

Dentre as hortaliças cultivadas a Alface (Lactuca sativa) destaca-se devido a sua fonte de vitaminas B1, B2, C, ferro e minerais, além da disponibilidade de ser cultivada em quase todas as regiões do globo terrestre. Diante do exposto, o objetivo do trabalho foi avaliar, em uma cultura de alface, a massa fresca de parte aérea e massa fresca da raiz com aplicação do ZEBMAX®. O experimento foi realizado à campo no Colégio Agrícola de Toledo no período de 10 de junho a 15 de julho de 2018. No tratamento foram realizadas aplicações de duas doses de 0,5 ml L-1 aos 15 e 25 dias após o transplantio. Já na testemunha só foi utilizada água. Utilizou-se o delineamento de blocos ao acaso em triplicata e no total foram avaliadas 10 plantas por bloco. Os dados foram submetidos às análises estatísticas usando o teste de Tukey, ao nível de 5 % de probabilidade. As plantas do tratamento obtiveram um peso de massa fresca de parte aérea de 12,55 g pl-1, com a massa fresca de raiz de 10,88 g pl-1, já na testemunha o peso da massa fresca de parte aérea ficou 11,08 g pl-1 com a massa fresca de raiz 9,44 g pl-1. Portanto, o presente trabalho apresentou diferenças significativas para as variáveis de crescimento (raiz e da parte aérea), em relação a aplicação do ZEBMAX® como fonte de adubação, na relação entre o tratamento e a testemunha.

Palavras-chave: Massa Fresca de Parte Aérea. Massa Fresca de Raiz. Peso de Planta.

Abstract
Among the vegetables grown, Lettuce (Lactuca sativa) stands out due to its source of vitamins B1, B2, C, iron and minerals, in addition to the availability of being grown in almost all regions of the globe. Given the above, the objective of the work was to evaluate, in a lettuce culture, the fresh mass of aerial part and fresh mass of the root with the application of the ZEBMAX®. The experiment was carried out in the field at the Colégio Agrícola de Toledo from June 10 to July 15, 2018. In the treatment, two doses of 0.5 ml L-1 were applied at 15 and 25 days after transplanting. In the witness, only water was used. A randomized block design in triplicate was used and a total of 10 plants per block were evaluated. The data were submitted to statistical analysis using the Tukey test, at the level of 5% probability. The treatment plants obtained a weight of fresh mass of aerial part of 12.55 g pl-1, with a fresh root mass of 10.88 g pl-1, while in the control the weight of fresh mass of aerial part was 11.08 g pl-1 with fresh root mass 9.44 g pl-1. Therefore, the present study showed significant differences for the growth variables (root and shoot), in relation to the application of ZEBMAX® as a source of fertilization, in the relationship between the treatment and the control.

Keywords: Fresh Mass Of Aerial Part. Fresh Root Pasta. Plant Weight.
Avaliação das Variantes Genéticas dos Genes AMELX e ENAM na Cárie Dentária em Adolescentes
Authors: Paschoalini Romagni Gabriela , Marino Costa Paula , Mara Maciel Sandra , Jacobucci Maria Paula , Célia Poli-Frederico Regina 
Published: April 2021

A doença cárie é considerada, atualmente, como biofilme sacarose dependente, entretanto, estudos recentes apontam que fatores genéticos também podem influenciar seu desenvolvimento. Variantes nos gene amelogenina (AMELX) e enamelina (ENAM), responsáveis pela formação do esmalte, têm sido propostas como potencialmente envolvidos na doença. O objetivo deste estudo foi avaliar se a ocorrência de cárie dentária em adolescentes está relacionado às variantes nos genes AMELX e ENAM. Para a avaliação da prevalência de cárie foi utilizado o índice de dentes cariados, perdidos e obturados (CPO-D), segundo critérios da Organização Mundial de Saúde. As amostras de DNA foram extraídas das células da mucosa oral. Para a análise dos polimorfismos de nucleotídeo único (SNPs) dos genes AMELX (rs17878486) e ENAM (rs7671281) foi utilizada a técnica de amplificação de fragmentos de DNA pela reação em cadeia da polimerase foi realizada (PCR) em tempo real pelo sistema TaqMan (Applied Biosystems, Foster City, EUA). Para a análise estatística, foi utilizado o teste exato de Fisher e qui-quadrado com nível de significância de 5%. Apenas os fatores socioeconômicos influenciaram a experiência de cárie. Concluiu-se que o componente genético, na população deste estudo, não influenciou o desenvolvimento da cárie.

Palavras-chave: Polimorfismo genético. Adolescentes. Esmalte.

Abstract
Caries disease is currently considered a sucrose-dependent biofilm, however recent studies indicate that a genetic component can also influence its development. Variants in the amelogenin (AMELX) and enamelin (ENAM) genes, responsible for the enamel formation, have been proposed as potentially involved in the disease. The purpose of this study was to evaluate whether the occurrence of dental caries in adolescents is related to variants in the AMELX and ENAM genes. To assess the caries prevalence, the index of decayed, missing and filled teeth (DMFT) were used, according to World Health Organization criteria. DNA samples were extracted from oral mucosa cells. For the analysis of single nucleotide polymorphisms (SNPs) of the AMELX (rs17878486) and ENAM (rs7671281) genes, the amplifying DNA fragments technique by the polymerase chain reaction was performed (PCR) in real time by the TaqMan system (Applied Biosystems, Foster City, USA). For the statistical analysis, Fisher's exact test and chi-square were used with a 5% significance level. Only socioeconomic factors influenced the caries experience. It was concluded that the genetic component in the population of this study, did not influence the development of caries.

Keywords: Genetic polymorphism. Adolescents. Enamel.
Hormonal effects of drosperinone and ethinyl estradiol based combined oral contraceptives on polycystic ovarian syndrome
Authors: Nayak Madhusmita S. , Kala Deepa D. , Agarwal Amit 
Published: April 2021

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder treated with combined oral contraceptives (COCs). The androgenic potential of any type of COC is in part determined by the progestin present. A newer form of progestin, drospirenone, has been recently introduced, and is available in combination with ethinyl estradiol.Methods: The study was conducted on 60 patients fulfilling inclusion criteria, in the department of obstetrics and gynecology, Terna Medical College and Hospital. Patients were diagnosed as PCOS according to Rotterdam criteria. After initial evaluation, blood samples were sent for levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), dehydroepiandrosterone-sulphate (DHEA-S), free testosterone, sex hormone binding globulin (SHBG). Each patient was advised to take a combination of EE (30 mcg) + drosperinone (3 mg), 1 tablet daily from the second day of her menstruation for 21 days then a 7 days gap and again for 21 days and so on cyclically for 3 cycles, then to repeat the tests as done at the beginning. Hirsutism was assessed clinically using the Ferriman-Gallwey scale at initial visit and three months later.Results: We found a significant improvement in the Serum LH, FSH levels and a significant fall in free testosterone levels accompanied by a rise in SHBG levels. There is also overall improvement in the hirsutism scores.Conclusions: Drosperinone based COCs are a good and effective means of treatment of PCOS. Treatment duration of three months was found to be effective in our study.