bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Diuretic-Sparing Effects of Sacubitril-Valsartan: Staying in the Loop
Authors: Orvin Nicholas J. , Beavers Janna C. , Russell Stuart D. 
Published: April 2021

Background: Previous literature has suggested a potential diuretic sparing effect as early as 6 months following sacubitril-valsartan initiation in patients with heart failure with reduced ejection fraction (HFrEF); however, whether this effect manifests earlier after initiation is unclear. Objective: To evaluate the acute diuretic-sparing effects of sacubitril-valsartan. Methods: This was a single-center, retrospective analysis of outpatients with HFrEF initiated on sacubitril-valsartan with follow up within 90 ± 30 days and a concomitant loop diuretic prescription. The primary outcome was the percent of patients with an increase, decrease or no change in loop diuretic total daily dose (TDD). Key secondary outcomes included change in loop diuretic TDD (mg furosemide equivalents) and hospital admissions or emergency department (ED) visits. Results: A total of 145 patients were included (overall cohort) with 120 continuing sacubitril-valsartan at follow up (on-treatment cohort). In the on-treatment cohort, 20% (n = 24) had a reduction in loop diuretic TDD and 10% had an increase (n = 12). Median change in loop diuretic TDD was unchanged from baseline to follow up (p 0.13). In patients on >80 mg TDD of furosemide at baseline (n = 9), mean change was-53 ± 44 mg (p 0.006). Hospitalizations (6.2%) and ED visits (0.7%) for heart failure were infrequent. Conclusion: Patients may require a loop diuretic dose reduction within 2-3 months following sacubitril-valsartan initiation. This diuretic-sparing effect appears larger in those on higher baseline loop diuretic doses, and closer follow up may be warranted for these patients.
Factors associated with test failure in pregnant women undergoing cell-free DNA-based testing for fetal trisomy
Authors: Chang Jiazhen , Qi Qingwei , Zhou Xiya , Jiang Yulin , Hao Na , Liu Juntao 
Published: April 2021

Objective To investigate the factors associated with cell-free DNA test failure, and the optimal subsequent management of these pregnancies. Methods This was a retrospective study of 27,363 singleton pregnancies undergoing cell-free DNA testing. Women with cell-free DNA test failure were divided into a high-risk group and a low-risk group according to their indications. The subsequent management and pregnancy outcomes of these women were followed up. Results The rate of cell-free DNA test failure at the first sampling was 1.49%, and 78.4% of failures were due to a low fetal fraction. Of the 66 women who refused any subsequent management, an adverse pregnancy outcome was seen in 5 cases, all belonging to the high-risk group. Of the 13 low-risk women who chose second-trimester maternal serum screening, all obtained a low-risk maternal serum screening result and an unaffected pregnancy outcome. A redraw was chosen by 171 women, which yielded a result in 75.4% and their pregnancy outcomes were unaffected; 42 women had an uninformative result again and received an amniocentesis. As 158 women had an amniocentesis after the first sampling, this procedure was offered in 200 cases altogether. Abnormal genetic testing results were shown in six (3%, 6/200) cases, all in the high-risk group. Conclusions High-risk pregnant women with cell-free DNA test failure are at increased risk of adverse pregnancy outcomes. A second sampling for cell-free DNA test or maternal serum screening might be suggested to low-risk women. Invasive prenatal diagnosis should be offered to the high-risk patients, especially those with a second cell-free DNA test failure.
EPPO and a common sense of justice
Authors: Elholm Thomas 
Published: April 2021

This article discusses the Union’s general inspirational idea of creating a ‘common sense of justice’ and its implications with reference to the development of the European Public Prosecutor. When the Commission presented its vision of an area of justice, it declared that the ‘ambition is to give citizens a common sense of justice throughout the Union’. Although a sense of justice seems to be something psychological and emotional, it also seems almost inevitably to promote EU integration. The article discusses the various roles that the EPPO may have in contributing to a common sense of justice and in particular the EPPO’s objective of achieving a Union-wide coherent practice on prosecution and penalty levels. It analyses critically whether this practice – by mediating between the different ‘common’ senses of justice in each Member State – is capable of contributing to a common sense of justice.
Utilizing the ACCESS Model to Understand Communication With the Ultraorthodox Community in Beit Shemesh During the First Wave of COVID-19
Authors: Romem Anat , Pinchas-Mizrachi Ronit , Zalcman Beth G. 
Published: April 2021

Introduction The coronavirus pandemic has disproportionately negatively affected the ultraorthodox in Israel. Their unique characteristics and slow adoption of preventative health guidelines resulted in a significant increase in morbidity and mortality. To lower these rates, health and government authority figures employed methods to change the ultraorthodox community health behaviors. Methodology This study utilizes the ACCESS model for transcultural nursing to analyze the response by authorities to high infection rates in the large ultraorthodox community in city of Beit Shemesh during the first wave of the outbreak (through early May). Results The authorities employed all model components to varying degrees and found moderate success in changing health behaviors of the ultraorthodox. Discussion Employing the ACCESS model as a response to the health care crisis among the ultraorthodox community in Beit Shemesh led to some success in increased compliance, thus lowering morbidity rates. However, not establishing strong respect and rapport hindered the process.
A novel case of ocular cicatricial pemphigoid induced by levamisole-adulterated cocaine
Authors: Igwe Chinedu N , Robinson Fiona , Jones Sophie M 
Published: April 2021

Aim: To report a case of ocular cicatricial pemphigoid caused by levamisole-adulterated cocaine. Methods: Case report. Results: A 54-year-old woman with multi-systemic levamisole-induced vasculitis which triggered bilateral cicatrizing conjunctivitis refractory to conventional immunosuppressants due to continued cocaine misuse. Conclusion: Levamisole-induced vasculitis is a significant public health issue due to its popularity as an adulterant to cocaine. Our report suggests that levamisole caused vasculitis and ocular cicatricial pemphigoid in this case. Ocular manifestation of this syndrome is rare.
Aqueous misdirection syndrome following ab interno gelatin stent can be managed successfully with anterior vitrectomy approach
Authors: Kennedy Alasdair , Haddad Fadi , Georgopoulos Minas 
Published: April 2021

Introduction: Minimally invasive glaucoma surgery (MIGS) is a relatively new surgical technique available to glaucoma surgeons. The ab interno gelatin XEN stent (XEN®45, Allergan Inc., CA, USA) drains aqueous into the subconjunctival space and is theoretically less invasive than trabeculectomy and therefore carries less risk. Aqueous misdirection syndrome (AMS) is a rare but well-recognised complication of any intraocular surgery. Only four cases have been reported following XEN stents but their management and outcome was not discussed. We present a case of AMS following XEN implantation including management and outcome. Case presentation: A 78 year old lady with an axial length of 21.27 mm and a previous episode of acute angle closure glaucoma was treated with laser peripheral iridectomy and, later, clear crystalline lens extraction. However, she continued to have high intraocular pressure (IOP) and a shallow anterior chamber. Despite medical therapy, she developed worsening glaucoma. She had XEN implantation to her right eye with no intraoperative complication. Unfortunately, she developed signs of AMS. Medical and laser zonulohyaloidectomy failed to resolve the condition. She then had surgical iriodozonulohyaloidectomy and anterior vitrectomy which resolved the AMS. Discussion: Management of AMS has been well documented. However, incidence following novel surgical techniques, such as XEN implantation, is not well reported. We have shown that AMS following XEN can be successfully treated using an anterior approach.
Management of bleeding with a temporary arterial occlusion balloon in revision total hip arthroplasty
Authors: Ullmark Gösta , Ribers Hanna , Haller Olov 
Published: April 2021

Purpose: Perioperative bleeding is an undesirable surgical phenomenon. An effective way of diminishing bleeding is by use of a temporary arterial occlusion balloon (TAOB) to produce regional hypotension. We analysed TAOB-related complications at our institution occurring with total hip arthroplasties between years 2000 and 2016. We also compared the effect on bleeding for a TAOB group and a matched group during this same time. Patients and methods: 76 consecutive cases had a total hip arthroplasty (THA) combined with a TAOB. In an analysis of all complications connected to the use of TAOB, 48 of them were revision THAs. The matched reference group consisted of 20 patients with revision surgery, but without TAOB. We analysed and compared perioperative bleeding, surgery, and balloon occlusion time for these 2 groups. Results: No thromboembolic complications or other severe complications were recorded. 1 case had bleeding from the insertion site after catheter removal. 3 cases had balloon failure without the consequences of this complication. The TAOB group had significantly less haemoglobin loss, total perioperative bleeding, bleeding per minute, and total transfusion than the matched reference group. Interpretation: The use of TAOB in elective THA surgery is safe and effective in reducing intraoperative bleeding.
Application of the Spanish-Language Consultation and Relational Empathy (CARE) Measure to Assess Patient-Centered Care Among Latino Populations
Authors: La Flair Lareina N. , Christensen Anna L. , Brown Jonathan D. , Wissow Lawrence S. 
Published: April 2021

Introduction: Reliable and valid measures are needed to assess the patient-centeredness of clinical care among Latino populations. Methods: We translated the Consultation and Relational Empathy (CARE) measure from English to Spanish and assessed its psychometric properties using data from 349 Latino parents/guardians visiting a pediatric clinic. Using confirmatory factor analysis, we examined the psychometric properties of the Spanish CARE measure. Results: Internal reliability of the Spanish CARE measure was high (Omega coefficient = 0.95). Similar to the English-language CARE measure, factor analysis of the Spanish CARE measure yielded a single domain of patient-centeredness with high item loadings (factor loadings range from 0.79 to 0.96). Conclusion: This preliminary analysis supports the reliability and validity of the Spanish version of the CARE measure among Latinos in pediatric care settings. With further testing, the Spanish CARE measure may be a useful tool for tracking and improving the health care delivered to Latino populations.
Elites and Culture: Social Profiles in the Cultivated Population
Authors: Ariño Villarroya Antonio , Llopis-Goig Ramon 
Published: April 2021

Since the 1990s, the central references of the sociology of cultural practices have been the theoretical frameworks developed by Pierre Bourdieu and Richard A. Peterson around the concepts of distinction and omnivorousness. This article is based on these frameworks; it revises them together with those of Donnat and Lahire and postulates that the terms of cultural classification and especially those of the upper classes (distinguished and omnivorous) require revision. The article also claims that there are diverse socio-cultural profiles due to the fact that there is never a single logic of differentiation of tastes, and that the results of the present research demand a new conceptual framework capable of showing the operation of diverse logics of differentiation and hierarchy. In order to do this, an analysis of the socio-cultural profiles of the cultivated groups in Spanish society is carried out on the data obtained from the Survey of Cultural Habits and Practices in Spain 2018/19. This work proves the existence of three types of cultivated population – classical, modern and syncretic – with notable differences in their cultural interests and practices, as well as in their underlying sociodemographic features and aesthetic logics, and concludes by posing the need to delve into the latter in what it defines as the study of cultural practice regimes.
Multiple daily insulin injections ameliorate QT interval by lowering blood glucose levels in patients with type 2 diabetes
Authors: Kobayashi Shunsuke , Nagao Mototsugu , Fukuda Izumi , Oikawa Shinichi , Sugihara Hitoshi 
Published: April 2021

Background: A prolonged QT interval plays a causal role in fatal arrhythmia and is known to be a risk factor for sudden cardiac death. Although diabetic patients with microvascular complications tend to have a longer QT interval, the therapeutic effect of diabetes on the QT interval remains unclear. Here, we assessed the changes in QT interval in patients with type 2 diabetes (T2D) who received multiple daily insulin injections. Materials and methods: Patients with T2D ( n = 34) who were admitted to our hospital and initiated multiple daily insulin injections for glycemic control were enrolled in this study. Clinical measurements, including electrocardiogram, were taken on admission and discharge. The QT interval was measured manually in lead II on the electrocardiogram, and corrected QT interval (QTc) was calculated using Bazett’s formula. The change in QTc (ΔQTc) during hospitalization (median, 15 days) and clinical parameters affecting ΔQTc were investigated. Results: QTc was shortened from 439 ± 24 to 427 ± 26 ms during hospitalization ( p < 0.0001). ΔQTc was positively correlated with the changes in fasting plasma glucose (ΔFPG, r = 0.55, p = 0.0008) and glycated albumin ( r = 0.38, p = 0.026) following insulin therapy, but not with the final dose of insulin ( r = −0.20, p = 0.26). The multiple regression analyses revealed that ΔFPG was independently associated with ΔQTc. Conclusions: Multiple daily insulin injections can ameliorate QT interval by lowering the blood glucose levels in T2D, suggesting that glycemic control is important for preventing patients with T2D from sudden cardiac death.
What’s driving dermatology? Contribution title analysis of the largest German Dermatology Congress 2019
Authors: Kaczmarczyk Robert , King Felix , Biedermann Tilo , Zink Alexander 
Published: April 2021

Background Every two years, German-speaking dermatologic specialist groups gather in Berlin to share the latest developments at Germanýs largest dermatologic conference, the Annual Meeting of the Germany Society of Dermatology (DDG). Because this conference has a lasting effect on dermatologic practice and research, understanding what is moving the specialist groups means understanding what is driving dermatology in Germany. Methods We used word network analysis to compile and visualize the information embedded in the contribution titles to the DDG Annual Meeting in 2019. We extracted words, contributing cities and inter-connections. The data was standardized, visualized using network graphs and analyzed using common network analysis parameters. Results A total of 5509 words were extracted from 1150 contribution titles. The most frequently used words were “therapy”, “patients”, and “psoriasis”. The highest number of contributions came from Hamburg, Berlin and Munich. High diversity in research topics was found, as well as a well-connected research network. Conclusions Focus of the well-connected German-speaking dermatology community meeting 2019 was patient and therapy centered and lies especially on the diseases psoriasis and melanoma. Network graph analysis can provide helpful insights and help planning future congresses. It can facilitate the choice which contributors to include as imbalances become apparent. Moreover, it can help distributing the topics more evenly across the whole dermatologic spectrum.
Reliability of a Novel Scoring System for MRI Assessment of Severity in Gluteal Tendinopathy: The Melbourne Hip MRI Score
Authors: Tso Chi Kin Nathan , O’Sullivan Richard , Khan Hussain , Fitzpatrick Jane 
Published: April 2021

Background: Gluteal tendinopathy is commonly reported in the literature, but there is a need for a validated magnetic resonance imaging (MRI)-based scoring system to grade the severity of the tendinopathy. Purpose: To use intra- and interobserver reliability to validate a new scoring system, the Melbourne Hip MRI (MHIP) score, for assessing the severity of gluteal tendinopathy. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: The MHIP score assesses gluteal tendinopathy according to each 1 of 5 categories: (1) extent of tendon pathology (maximum 5 points); (2) muscle atrophy (maximum 4 points); (3) trochanteric bursitis (maximum 4 points); (4) cortical irregularity (maximum 3 points); and (5) bone marrow edema (maximum 1 point), with an overall range of 0 to 17 (most severe). A total of 41 deidentified MRI scans from 40 patients diagnosed with gluteal tendinopathy (mean baseline age, 57.44 ± 25.26 years; 4 male, 36 female) were read and graded according to MHIP criteria by 2 experienced musculoskeletal radiologists. The radiologists were blinded to previous reports, and the scans were read twice within a 2-month period. Statistical analysis using the intraclass correlation coefficient (ICC) was used to determine intra- and interobserver reliability and mean/range for the MHIP scores. Results: Of a total of 123 readings, the mean MHIP score (±SD) was 3.93 ± 2.24 (range, 0-17 points). The MHIP score demonstrated excellent reliability for determining the severity of gluteal tendinopathy on MRI. The ICC for intra- and interobserver reliability was 0.81 (95% CI, 0.67-0.89) and 0.78 (95% CI, 0.62-0.87), respectively. Conclusion: The MHIP score had excellent intra- and interobserver reliability in scoring gluteal tendinopathy. This score allows gluteal tendon pathology to be graded prior to treatment and to be used for standardized comparisons between results in future research undertaking radiological review of gluteal tendinopathy.
Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review
Authors: Phimarn Wiraphol , Sungthong Bunleu , Itabe Hiroyuki 
Published: April 2021

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.
Prognostic factors affecting macular hole closure types
Authors: Gümüş Gülşah , Demir Gökhan , Tülü Aygün Beril , Demircan Ali , Alkın Zeynep , Öztornacı Onur 
Published: April 2021

Purpose: In this study, we aimed to evaluate the relationship between macular hole closure types assessed by optical coherence tomography (OCT) and the preoperative prognostic factors. Materials and methods: In total, 183 patients who underwent pars plana vitrectomy and internal limiting membrane peeling for idiopathic macular hole between August 2014 and August 2019 were reviewed retrospectively. The preoperative measurements of the macular hole including minimum linear diameter (MLD), basal hole diameter (BHD) and hole height (HH) were measured on OCT images. The patients were divided into two closure types on the basis of postoperative OCT findings (type 1 closure: retinal edges were flat and there was no defect of the neurosensory retina on the fovea; type 2 closure: retinal edges were flat and there was a defect of the neurosensory retina on the fovea). The difference of prognostic factors such as age; duration of symptoms; preoperative best-corrected visual acuity (BCVA); preoperative macular hole measurements, including MLD, BHD and HH; and rate of reopening between two types were statistically analysed. Results: The mean age of patients was 66.33 ± 8.09 years (range: 48–88 years). According to OCT imaging, 117 eyes (63.9%) were classified into the type 1 closure group, and 66 eyes (36.1%) were classified into the type 2 closure group. There were no significant differences between two groups in age, duration of symptoms and preoperative BCVA ( p = 0.694, p = 0.092 and p = 0.15). MLD and BHD were significantly larger, and reopening was significantly more common in type 2 group ( p < 0.05, p = 0.04 and p < 0.005); however, there was no significant difference in HH between two groups ( p = 0.239). Conclusion: Preoperative horizontal measurements of macular hole may help to determine postoperative visual expectations and anatomical success, and predict the possibility of reopening.
Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage
Authors: Hu Linping , Yin Xiuxiu , Zhang Yawen , Pang Aiming , Xie Xiaowei , Yang Shangda , Zhu Caiying , Li Yapu , Zhang Biao , Huang Yaojin , Tian Yunhong , Wang Mei , Cao Wenbin , Chen Shulian , Zheng Yawei , Ma Shihui , Dong Fang , Hao Sha , Feng Sizhou , Ru Yongxin , Cheng Hui , Jiang Erlie , Cheng Tao 
Published: April 2021

Abstract
Total body irradiation (TBI) is commonly used in host conditioning regimens for human hematopoietic stem cell (HSC) transplantation to treat various hematological disorders. Exposure to TBI not only induces acute myelosuppression and immunosuppression, but also injures the various components of the HSC niche in recipients. Our previous study demonstrated that radiation-induced bystander effects (RIBE) of irradiated recipients decreased the long-term repopulating ability of transplanted mouse HSCs. However, RIBE on transplanted human HSCs have not been studied. Here, we report that RIBE impaired the long-term hematopoietic reconstitution of human HSCs as well as the colony-forming ability of human hematopoietic progenitor cells (HPCs). Our further analyses revealed that the RIBE-affected human hematopoietic cells showed enhanced DNA damage responses, cell-cycle arrest, and p53-dependent apoptosis, mainly because of oxidative stress. Moreover, multiple antioxidants could mitigate these bystander effects, though at different efficacies in vitro and in vivo. Taken together, these findings suggest that RIBE impair human HSCs and HPCs by oxidative DNA damage. This study provides definitive evidence for RIBE on transplanted human HSCs and further justifies the necessity of conducting clinical trials to evaluate different antioxidants to improve the efficacy of HSC transplantation for the patients with hematological or nonhematological disorders.