bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of an electronic patient-reported measure of barriers to antiretroviral therapy adherence with the Opal patient portal: Protocol for a mixed method type 3 hybrid pilot study at a large Montreal HIV clinic
Authors: Engler Kim , Vicente Serge , Ma Yuanchao , Hijal Tarek , Cox Joseph , Ahmed Sara , Klein Marina , Achiche Sofiane , Pant Pai Nitika , de Pokomandy Alexandra , Lacombe Karine , Lebouché Bertrand 
Published: December 2021

Background
Adherence to antiretroviral therapy (ART) remains problematic. Regular monitoring of its barriers is clinically recommended, however, patient-provider communication around adherence is often inadequate. Our team thus decided to develop a new electronically administered patient-reported outcome measure (PROM) of barriers to ART adherence (the I-Score) to systematically capture this data for physician consideration in routine HIV care. To prepare for a controlled definitive trial to test the I-Score intervention, a pilot study was designed. Its primary objectives are to evaluate patient and physician perceptions of the I-Score intervention and its implementation strategy.

Methods
This one-arm, 6-month study will adopt a mixed method type 3 implementation-effectiveness hybrid design and be conducted at the Chronic Viral Illness Service of the McGill University Health Centre (Montreal, Canada). Four HIV physicians and 32 of their HIV patients with known or suspected adherence problems will participate. The intervention will involve having patients complete the I-Score through a smartphone application (Opal), before meeting with their physician. Both patients and physicians will have access to the I-Score results, for consideration during the clinic visits at Times 1, 2 (3 months), and 3 (6 months). The implementation strategy will focus on stakeholder involvement, education, and training; promoting the intervention’s adaptability; and hiring an Application Manager to facilitate implementation. Implementation, patient, and service outcomes will be collected (Times 1-2-3). The primary outcome is the intervention’s acceptability to patients and physicians. Qualitative data obtained, in part, through physician focus groups (Times 2–3) and patient interviews (Times 2–3) will help evaluate the implementation strategy and inform any methodological adaptations.

Discussion
This study will help plan a definitive trial to test the efficacy of the I-Score intervention. It will generate needed data on electronic PROM interventions in routine HIV care that will help improve understanding of conditions for their successful implementation.

Clinical trial registration
ClinicalTrials.gov identifier: NCT04702412; https://clinicaltrials.gov/.
Identification of hub genes and construction of an mRNA-miRNA-lncRNA network of gastric carcinoma using integrated bioinformatics analysis
Authors: Wei Gang , Dong Youhong , He Zhongshi , Qiu Hu , Wu Yong , Chen Yongshun 
Published: December 2021

Background
Gastric carcinoma (GC) is one of the most common cancer globally. Despite its worldwide decline in incidence and mortality over the past decades, gastric cancer still has a poor prognosis. However, the key regulators driving this process and their exact mechanisms have not been thoroughly studied. This study aimed to identify hub genes to improve the prognostic prediction of GC and construct a messenger RNA-microRNA-long non-coding RNA(mRNA-miRNA-lncRNA) regulatory network.

Methods
The GSE66229 dataset, from the Gene Expression Omnibus (GEO) database, and The Cancer Genome Atlas (TCGA) database were used for the bioinformatic analysis. Differential gene expression analysis methods and Weighted Gene Co-expression Network Analysis (WGCNA) were used to identify a common set of differentially co-expressed genes in GC. The genes were validated using samples from TCGA database and further validation using the online tools GEPIA database and Kaplan-Meier(KM) plotter database. Gene set enrichment analysis(GSEA) was used to identify hub genes related to signaling pathways in GC. The RNAInter database and Cytoscape software were used to construct an mRNA-miRNA-lncRNA network.

Results
A total of 12 genes were identified as the common set of differentially co-expressed genes in GC. After verification of these genes, 3 hub genes, namely CTHRC1, FNDC1, and INHBA, were found to be upregulated in tumor and associated with poor GC patient survival. In addition, an mRNA-miRNA-lncRNA regulatory network was established, which included 12 lncRNAs, 5 miRNAs, and the 3 hub genes.

Conclusions
In summary, the identification of these hub genes and the establishment of the mRNA-miRNA-lncRNA regulatory network provide new insights into the underlying mechanisms of gastric carcinogenesis. In addition, the identified hub genes, CTHRC1, FNDC1, and INHBA, may serve as novel prognostic biomarkers and therapeutic targets.
COVID-19 associated hospitalization in 571 patients with fibromyalgia—A population-based study
Authors: Amital Mor , Ben-Shabat Niv , Amital Howard , Buskila Dan , Cohen Arnon D. , Amital Daniela 
Published: December 2021

Objective
To identify predicators of patients with fibromyalgia (FM) that are associated with a severe COVID-19 disease course.

Methods
We utilized the data base of the Clalit Health Services (CHS); the largest public organization in Israel, and extracted data concerning patients with FM. We matched two subjects without FM to each subject with FM by sex and age and geographic location. Baseline characteristics were evaluated by t-test for continuous variables and chi-square for categorical variables. Predictors of COVID-19 associated hospitalization were identified using univariable logistic regression model, significant variables were selected and analyzed by a multivariable logistic regression model.

Results
The initial cohort comprised 18,598 patients with FM and 36,985 matched controls. The mean age was 57.5± 14.5(SD), with a female dominance of 91%. Out of this cohort we extracted the study population, which included all patients contracted with COVID-19, and consisted of 571 patients with FM and 1008 controls. By multivariable analysis, the following variables were found to predict COVID-19 associated hospitalization in patients with FM: older age (OR, 1.25; CI, 1.13–1.39; p<0.001), male sex (OR, 2.63; CI, 1.18–5.88; p<0.05) and hypertension (OR, 1.75; CI, 1.04–2.95; p<0.05).

Conclusion
The current population-based study revealed that FM per se was not directly associated with COVID-19 hospitalization or related mortality. Yet classical risk factors endangering the general population were also relevant among patients with FM.
IMPLEMENTASI PAKET SHINY PADA PEMODELAN MULTISCALE AUTOREGRESSIVE UNTUK DATA HARGA SAHAM BBRI
Authors: Triyunanto Bahtiar Ilham , Suparti Suparti , Santoso Rukun 
Published: December 2021

Stocks are an investment that attract people because they can earn large profits by having claim rights to the company's income and assets so investors have to observe stock price movements in the future to achieve investment goals. One of the statistical methods for time series data modeling is ARIMA. However, modeling assumptions must be fulfilled to use that method so an alternative model is proposed, namely nonparametric regression model, which has no modeling assumptions requirement. In this study, the nonparametric regression multiscale autoregressive (MAR) with two different filter and decomposition level J are compared to choose the best model and forecast it. The data are closing stock price, high stock price and low stock price of BBRI’s stocks that divided into 2 parts, namely in sample data from March 19, 2020 to February 4, 2021 to form a model and out sample data from February 5, 2021 to March 23, 2021 used for evaluation of model performance based on MAPE values. The chosen best model for each stock price are the MAR model with wavelet haar filter and decomposition level 5 for the closing stock price which produces a MAPE value of 1.194%, the MAR model with wavelet haar filter and decomposition level 5 for the high stock price which produces a MAPE value of 1.283%, and the MAR model with a wavelet haar filter and decomposition level 5 for the low stock price which produces a MAPE value of 1.141%, indicating that the models have excellent forecasting capability. In this study, Graphical User Interface (GUI) using R software with the help of shiny package is also built, making data analyzing easier and generating more interactive display output.
Development of (−)-epigallocatechin-3-gallate-loaded folate receptor-targeted nanoparticles for prostate cancer treatment
Authors: Alserihi Read F. , Mohammed Mohammed Razeeth Shait , Kaleem Mohammed , Khan Mohammad Imran , Sechi Mario , Sanna Vanna , Zughaibi Torki A. , Abuzenadah Adel M. , Tabrez Shams 
Published: December 2021

Abstract
In continuation of our previous studies, we developed polymeric epigallocatechin 3-gallate (EGCG)-loaded nanoparticles (NPs) coupled with folic acid (FA), able to dually bind the human folate receptor alpha (FOLR1), and prostate-specific membrane antigen (PSMA+) in prostate cancer (PCa) model. After a preliminary computational molecular recognition of NP′ ligand binding on the FOLR1 active site, we synthesized the biocompatible block-copolymer PLGA–PEG–FA to prepare EGCG-targeted NPs (EGCG-T-NPs). The obtained NPs were characterized by various analytical techniques, and anticancer efficacy was determined by different sets of experiments in a 3D culture of PCa using PC3 and 22Rv1 cell lines. Results showed a significant reduction in spheroid size by EGCG-T-NPs, especially in PSMA+ (22Rv1) cells. The targeted NPs significantly enhanced the antiproliferative activity of EGCG against PCa cell lines, especially toward the PSMA+ cells, known to have higher FOLR1 expression. We did not observe any changes in the reactive oxygen species formation in both studied cell lines. However, significant changes in mitochondrial depolarization (15%) and polarization (18%) were recorded in response to EGCG-T-NP compared to control in 22Rv1. Similarly, EGCG-T-NP treatment also showed an increase in the number of dead apoptotic cells in 22Rv1 spheroids. Collectively, the obtained results support our hypothesis about the role of these targeted nanoprototypes in the increasing cellular uptake of EGCG payload into PCa cells, thus enhancing its antitumor efficacy.
The Reliability of Tensiomyography for Assessment of Muscle Function in the Healthy Population: A Systematic Review
Authors: Hanney William J. , Kolber Morey J. , Salamh Paul A. , Moise Stephon , Hampton Daniel , Wilson Abigail T. 
Published: December 2021

ABSTRACT
Tensiomyography (TMG) is a noninvasive tool used to assess contractile tissue properties during an isometric muscle contraction. Owing to portability and versatility for assessing muscle parameters, TMG may be of value to the strength and conditioning (S&C) specialist. The purpose of this systematic review was to investigate the reliability of TMG measurements. PubMed, PEDro, MEDLINE, and Cochrane databases were searched up to September 2021 by 2 authors, who independently examined all titles and abstracts to determine initial eligibility. Inclusion criteria included any study assessing the reliability of TMG parameters, published in English, published in a peer-reviewed scientific journal, and included participants with no significant musculoskeletal conditions. Exclusion criteria included the following elements: TMG assessment process not clearly delineated, reliability of specific TMG parameters not clearly defined, and statistical methods for determining reliability not clearly defined. All studies underwent a quality assessment using the Modified Downs and Black checklist for assessing quality studies, and results were extracted from qualified articles. In total, 635 studies were identified, with 16 studies retained after full-text reviews. Twelve studies had poor quality, whereas 4 had fair quality. Noninvasive TMG has good to excellent absolute and interrater reliability for measuring the properties of skeletal muscles.
ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ DİŞ HEKİMLİĞİ FAKÜLTESİNDEKİ KONİK IŞINLI BİLGİSAYARLI TOMOGRAFİ (KIBT) İNCELEMESİ İSTEM NEDENLERİNİN DEĞERLENDİRİLMESİ
Authors: SAGLAM Hande , YESİLOVA Esra , BAYRAKDAR İbrahim Şevki 
Published: December 2021

Amaç: Bu çalışmanın amacı Eskişehir Osmangazi Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Radyolojisi Anabilim Dalı Radyoloji kliniğinde çekilmiş Konik Işınlı Bilgisayarlı Tomografi (KIBT)’lerin hangi nedenlerle istendiğini belirlemektir.
Gereç-Yöntemler: Ağız, Diş ve Çene Radyolojisi arşivinden rastgele seçilen 843 KIBT’ın istem nedenleri retrospektif olarak değerlendirildi. Hasta bilgi ve yönetim sistemi üzerinde KIBT istemleri için hekimler tarafından kaydedilen Ön tanı/İstem gerekçelerine göre nedenler sınıflandırıldı ve frekansları hesaplandı.
Bulgular: Hastaların 403’ü erkek ve 440’ı kadındı. Yaş aralıkları 6-83 (ort 29.41±17.212) idi. En sık istem nedeni olan patolojiler 228 vaka ile % 27 oranındaydı. Ortodontik sebeplerle istenen 185 (% 21.9) ve gömülü dişler için istenen 169 (% 20) vaka ikinci ve üçüncü grupları oluşturuyordu. Maksillofasiyal travma nedeniyle KIBT istenen dört vaka % 0.5 oranla en alt sıradaydı.
Sonuç: KIBT’ın uygun maliyeti, düşük radyasyon dozuyla üç boyutlu olarak görüntü oluşturması gibi özellikleri sayesinde diş hekimliği pratiğinde kullanımı yaygınlaşmış olup farklı amaçlar için tercih edilmektedir. Bu avantajlarına rağmen KIBT kullanımında ALARA (As Low As Reasonably Achievable) prensipleri göz önünde bulundurulmalı ve gerekli olmayan durumlarda KIBT isteminden kaçınılmalıdır.
2014-2016 Yılları Arasında Periodontoloji Kliniğine Başvuran Hastaların Periodontal Durum, Sistemik Hastalık ve Kişisel Alışkanlıklarının Değerlendirilmesi
Authors: MERACI Bilge , GÜNPINAR Şadiye 
Published: December 2021

Amaç: Bu kesitsel retrospektif çalışmanın amacı, Bolu Abant İzzet Baysal Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalı öğrenci kliniğinde başlangıç periodontal tedavileri yapılan 1800 hastanın sistemik hastalık, periodontal durum ve kişisel alışkanlıklarının değerlendirilmesidir.
Gereç ve Yöntemler: Çalışmaya dahil edilen bireylerin hasta formlarına kaydedilmiş olan demografik, dental şikayet ve sistemik durum bilgileri, sigara kullanımı, bruksizm ve ağız solunumu varlığı ile periodontal klinik parametreleri değerlendirildi. Bireyler periodontal durumlarına göre gingivitis (G), kronik periodontitis (KP) ve agresif periodontitis (AgP) olmak üzere üç gruba ayrıldı. Oluşturulan gruplar periodontal klinik parametreler (plak indeksi, gingival indeks, sondalamada kanama), sistemik hastalık (tip 2 diyabet, hipertansiyon ve kardiyovasküler hastalıklar gibi) ve kişisel alışkanlıklar açısından karşılaştırıldı. Verilerin istatistiksel analizleri SPSS 23.0 paket programı kullanılarak yapıldı.
Bulgular: Çalışma popülasyonunun (%59.5’i kadın ve %40.5’i erkek) yaş ortalamasının 29.48±11.75 olduğu belirlendi. Hastaların %70.8’ine G, %28.7’sine KP ve %0.5’ine ise AgP teşhisi konulduğu saptandı. Erkek hastalarda sigara kullanımı prevalansının kadın hastalardan daha yüksek olduğu görüldü (p0.05); tiroid hastalıkları ve alerji durumunun kadınlarda erkeklere göre daha yüksek oranda olduğu tespit edildi (p
The Book Cover as a Paratext: Biblia Germanicolatina in the Martynas Mažvydas National Library of Lithuania
Authors: Kvizikevičiūtė Milda 
Published: December 2021

The book cover of Biblia Germanicolatina (1565), which is held at the Rare Books and Manuscrips Unit of the Martynas Mažvydas National Library of Lithuania, is analysed in this paper. This Bible was printed in a 20-volume collection in Wittenberg on request of August the Elect of Saxony (1526–1586). It was printed in the Latin and German languages. This Bible later became a part of various European libraries. Biblia Germanicolatina is analysed in the light of the paratext theory, which as a book history term is first used by French literary theorist Gerard Genette (1987). Genette used this term to describe objects and subjects surrounding the text: text spacing, lettering, book covers and even book advertisements. The analysis is performed using the provenance method, which leads to discovering the origins of the book’s binding and its primary sources. As of right now, five out of the 20 volumes from the collection are known to be held in Lithuanian memory institutions. As a result of this research, we were able to identify the bookbinder from Wittenberg who ordered the plate for tooling in 1564.
Improvements of 210Po determination method in thermal water samples
Authors: Hao Duong Van- , Nguyen Dinh Chau , Phan Trong Trinh , Tien Chu Trung- 
Published: December 2021

Determination of naturally radionuclides have been known well as an important topic in environmental study in recently. One of the most toxic radioisotope in nature, a daughter product of 238U decay chain is 210Po (polonium). The improvement and optimizations methods for determination of this attractive isotope are still presenting so far. In this paper, a new improved method was elaborated for 210Po determination in thermal water sample. In the proposed method, analytical optimization of spontaneous/auto deposition does not use Teflon cup, magnetic stirring or any preparing equipment/item only normal glass and a side of square silver. In addition, the optimization was neglected with absent of purification of polonium (Liquid-liquid extraction methods/Ion exchange chromatography/Extraction chromatographic separations). The outcome of optimal procedure were simplify, less time consuming, great reduction of costs with chemical recovery >80% and could apply for any liquid environmental samples.
О социальной природе коммуникативных нарушений: производство коммуникативной (не)компетентности во взаимодействии
Authors: Колядов Дмитрий Михайлович 
Published: December 2021

Одной из определяющих характеристик интеллектуальных нарушений, отмечаемой в специализированной литературе, являются трудности социального функционирования или адаптации. Эти трудности касаются не только способности контролировать финансы, устраиваться на работу и удерживаться на ней или вступать в брак, но и коммуникации. Коммуникативные проблемы, с которыми сталкиваются люди с интеллектуальными нарушениями, разнообразны. Это могут быть проблемы, связанные с несоблюдением норм речевого этикета, с пониманием юмора, значений, которые передаются имплицитно (намек, ирония, метафорические выражения). В целом такого рода затруднения могут быть охарактеризованы как нехватка коммуникативной компетентности. Последняя мыслится специалистами учреждений здравоохранения, образования, социального обслуживания населения, сталкивающимися с людьми с нарушениями, как обусловленная имеющимися у индивида дефектами интеллекта или психики. Однако с позиций конверсационно-аналитической традиции, которой следует представленная статья, недостаточность коммуникативной компетентности может быть описана как феномен, ситуативно возникающий во взаимодействии. В статье рассматривается эпизод из группового занятия в центре дневного пребывания для молодых людей с нарушениями. В этом эпизоде один из клиентов центра рассказывает анекдот, оказавшийся не вполне удачным с точки зрения других участников эпизода. На первый взгляд эта неудача может показаться следствием индивидуальных действий рассказчика (выбор анекдота, манера рассказывания), которые, в свою очередь, могут объясняться имеющимися у него нарушениями. Однако анализ демонстрирует, что эта неудача создается несколькими участниками в процессе взаимодействия. Во-первых, само появление и выбор анекдота инициируется партнерами рассказчика – сотрудниками центра. Во-вторых, последующие действия партнеров влияют на определение компетентности рассказчика. С одной стороны, эти действия конструируют ситуацию как педагогическое взаимодействие, т. е. проверку способностей участника с нарушениями, а не как спонтанное рассказывание анекдота. С другой стороны, эти действия приводят к выявлению и подчеркиванию того, что анекдот не является смешным.
Рейтинг субъектов Российской Федерации по уровню развития сопровождаемого проживания инвалидов
Authors: Кожушко Людмила Александровна , Владимирова Оксана Николаевна 
Published: December 2021

В статье анализируется новое направление в комплексной реабилитации и абилитации людей с инвалидностью – сопровождаемое проживание. По результатам оценки уровня развития и динамики составлен рейтинг субъектов Российской Федерации, который дает возможность сравнить позиции регионов, выявить их сильные и слабые стороны, а также является инструментом для разработки мер и планирования мероприятий по дальнейшему совершенствованию этого направления. Исследование проведено по результатам анализа материалов ежегодного мониторинга, представленных исполнительными органами власти всех субъектов Российской Федерации. В качестве критериев оценки учитывались десять индикаторов, отражающих системность и эффективность развития сопровождаемого проживания. Для обработки результатов использовались методы параметрической статистики. В результате все субъекты распределены на группы – от очень высокого уровня до крайне низкого. Выявлены регионы-лидеры и аутсайдеры по развитию сопровождаемого проживания, определены мероприятия, позволившие занять отдельным субъектам лидирующее положение в рейтинге, изучены проблемы, затрудняющие внедрение технологий в отстающих субъектах и предложены меры воздействия для улучшения работы в этом направлении. Как показало исследование, наличие большого количества регионов, с уровнем и развитием ниже среднего, свидетельствует, что становление технологий сопровождаемого проживания находится на начальном этапе развития. Основными мерами для повышения уровня реализации программ сопровождаемого проживания являются: разработка нормативных и методических документов в этой области; формирование реестра нуждающихся в данной форме жизнеустройства; разработка регламентов предоставления социальных услуг с целью сопровождаемого проживания; организация, координация и межведомственное взаимодействие по вопросам сопровождаемого проживания; определение источников финансирования технологий; обучение специалистов; проведение информационной работы среди населения. Предложенные мероприятия могут быть использованы для совершенствования программ по развитию сопровождаемого проживания и определению подходов к деинституализации интернатной системы России в целом.