bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proses digitalisasi naskah kuno sebagai pelestarian informasi di Museum Bandar Cimanuk Indramayu
Authors: Khadjah Ute Lies Siti , Perdana Fitri , Kirana Sarasvathi Desak Gde Delonix Regia , Winoto Yunus 
Published: November 2021

Introduction. One of the most valuable cultural heritage of the Indonesian nation's ancestors is the ancient manuscript. Ancient manuscripts can be found in every region in Indonesia, especially Indramayu. Most of the ancient manuscripts found in Indramayu have been kept at the Bandar Cimanuk Museum, Indramayu. Most of the ancient manuscripts in the Bandar Cimanuk Museum, Indramayu, are written by hand or in the original form before printing. Digitalization is the process of transferring document media from printed, audio, and video forms. Equipment used in digitizing activities includes software and hardware. In digitizing ancient manuscripts, there are 2 stages that must be followed, pre-digitization and organizing.Data Collection Methods. Using a qualitative methods and descriptive approach with a case study category. Data Analysis. The survey data were descriptively analysed by using 3 steps there are reduction, presentation and conclutsin . Result and Discussion.The result of the process of digitizing an ancient manuscript is an ancient manuscript in digital format. The results show that after the ancient manuscripts in the museum have been digitized, they can provide information according to the needs of the manuscript users and can preserve the information contained in the ancient manuscripts found at the Bandar Cimanuk Museum, Indramayu.Conclusion. Based on the results that have been found in digitizing ancient manuscripts at the Bandar Cimanuk Museum, Indramayu, there are a number of stages that must be carried out, namely the pre-digitalization stage and the organizing stage.
Perioperative Botulinum Toxin A in the Surgical Management of Seizure-Related Shoulder Instability
Authors: Edwards Matthew D. , Koontz Elizabeth H. , Revuelta Gonzalo J. , Edwards Jonathan C. , Slone Harris S. , Woolf Shane K. 
Published: November 2021

Case:
A 20-year-old woman presented with recurrent bilateral shoulder instability concurrent with severe, treatment-refractory epilepsy. Imaging revealed glenoid bone loss of 25% to 28% and large Hill-Sachs defects bilaterally. Bone graft augmentation of the glenoid and infill of the Hill-Sachs defects was performed bilaterally. Perioperative neuromuscular paralysis of shoulder girdle muscles with botulinum toxin was performed to facilitate recovery. Both shoulders at 2.5 and 4 years, respectively, demonstrate excellent stability and radiographic union despite continued seizure activity.

Conclusion:
Perioperative neuromuscular paralysis with botulinum toxin may provide early graft protection after the surgical treatment of glenohumeral instability because of seizures.
The Coexistence of Spontaneous Femoral Nerve Palsy and Developmental Dysplasia of the Hip in a Breech-Presenting Newborn
Authors: Ertan Birsel Sema , Sarıkaya İlker Abdullah , Erdal Ozan Ali , Görgün Barış , İnan Muharrem 
Published: November 2021

Case:
In this report, we present an infant who was diagnosed with femoral nerve palsy (FNP) and developmental dysplasia of the hip (DDH) on the same side after delivery. The patient was treated with hip alternative abduction orthosis, which did not force hip flexion with satisfactory results.

Conclusion:
FNP in newborns with DDH is usually described as a possible complication of the Pavlik harness treatment. However, there is only one report that presents 2 cases. Our objective is to raise awareness of this very rare condition because performing an early intervention is vital to achieving an optimal therapeutic result.
Endoscopic Shelf Procedure and Ischiofemoral Decompression with Arthroscopic Acetabular Labral Reconstruction
Authors: Maldonado David R. , Owens Jade S. , Jimenez Andrew E. , Saks Benjamin R. , Lall Ajay C. , Domb Benjamin G. 
Published: November 2021

Case:
A 43-year-old female patient complained of pain in the right hip. The diagnoses of hip dysplasia, ischiofemoral impingement (IFI), femoroacetabular (FAI) cam-type morphology, and labral tear were made. The patient underwent hip arthroscopy with labral reconstruction for an irreparable labral tear and cam-morphology correction, and hip endoscopy for shelf procedure and ischiofemoral decompression. Favorable outcomes were reported at 1-year follow-up.

Conclusion:
Hip arthroscopy for FAI cam-type morphology with labral reconstruction and concomitant hip endoscopy for shelf and ischiofemoral decompression seem to be safe for the treatment of active young adult patients with FAI cam-type morphology, irreparable labral tear, dysplasia, and IFI diagnoses. Nevertheless, the results presented should not be extrapolated as this is a case report.
Plate-Tensioned-Nail for Salvage of Failed Subtrochanteric Intramedullary Motorized Limb Lengthening
Authors: Patterson Joseph T. 
Published: November 2021

Case:
A 43-year-old insulin-dependent man with a 4.4-cm posttraumatic femoral limb length discrepancy sustained a subtrochanteric femur fracture associated with failure of a motorized intramedullary limb lengthening nail during distraction osteogenesis. The patient requested a single-stage salvage operation. After implant removal, the femur was stabilized and compressed with a plate-tensioned-nail construct consisting of 4.5-mm locking compression plate tensioned and linked to a femoral reconstruction nail through interlocking screws with immediate weight-bearing.

Conclusion:
A plate-tensioned-nail construct is a single-stage salvage option for a length-unstable subtrochanteric nonunion which permits immediate full weight-bearing.
Spinal Hypertrophic Pachymeningitis Causing Thoracic Myelopathy in a Patient of Takayasu Arteritis
Authors: Murugan Chandhan , Kavishwar Rohit Akshay , Ramachandran Karthik , Shetty Ajoy Prasad , B. T. Pushpa , Rajasekaran S. 
Published: November 2021

Case:
A 52-year-old man presented with thoracic myelopathy, and his magnetic resonance imaging (MRI) was suggestive of T1-T4 hypertrophic-pachymeningitis. Incidentally, circumferential thickening of the infra-renal abdominal aorta and right common iliac artery was seen, which along with the findings in a contrast computed tomography was consistent with Takayasu arteritis (TA). The patient underwent T1-T4 laminectomy, thinning of dura, biopsy, and steroid therapy. At the 1-year follow-up, he was asymptomatic and MRI revealed resolution of the lesion.

Conclusion:
This is the first report describing an association between TA and hypertrophic spinal pachymeningitis, emphasizing the unusual neurological manifestation of myelopathy and complete resolution of symptoms with timely and appropriate intervention.
Injury to the Meniscofemoral Portion of the Deep MCL Is Associated with Medial Femoral Condyle Bone Marrow Edema in ACL Ruptures
Authors: Moran Jay , Katz Lee D. , Schneble Christopher A. , Li Don , Kahan Joseph B. , Wang Annie , Porrino Jack , Jokl Peter , Hewett Timothy E. , Medvecky Michael J. 
Published: November 2021

Background:
The primary goal of the present study was to investigate injury to the deep medial collateral ligament (MCL), specifically the meniscofemoral ligament (MFL) portion, and its association with medial femoral condyle (MFC) bone marrow edema in acute anterior cruciate ligament (ACL) ruptures. The secondary goal was to examine the association between MFL injury and medial meniscal tears (MMTs) in these same patients.

Methods:
Preoperative magnetic resonance imaging (MRI) scans of 55 patients who underwent ACL reconstruction surgery were retrospectively reviewed by 2 board-certified musculoskeletal radiologists. MRI scans were examined for MFC edema at the insertion site of the MFL. This site on the MFC was referred to as the central-femoral-medial-medial (C-FMM) zone based on the coronal and sagittal locations on MRI. The presence or absence of bone marrow edema within this zone was noted. The prevalence, grade, and location of superficial MCL and MFL injuries were also recorded on MRI. The correlations between MFL injuries and the presence of MFC bone marrow edema were examined. Lastly, the presence and location of MMTs were also recorded on MRI and were confirmed on arthroscopy, according to the operative notes.

Results:
On MRI, 40 (73%) of the 55 patients had MFL injuries. MFL injuries were significantly more common than superficial MCL injuries (p = 0.0001). Of the 27 patients with C-FMM bruising, 93% (25 patients) had MFL tears (p < 0.00001). In addition, of the 40 patients with an MFL injury, 63% (25 patients) had C-FMM bruising (p = 0.0251). Chi-square testing showed that MMTs and MFL injuries were significantly associated, with 12 (100%) of 12 patients with MMTs also having a concomitant MFL injury (p = 0.0164).

Conclusions:
The prevalence of MFL injury in ACL ruptures is high and MFC bone marrow edema at the MFL insertion site should raise suspicion of injury. MFL injuries can present with clinically normal medial ligamentous laxity in ACL ruptures. Additionally, MFL injuries were significantly associated with posterior horn MMTs, which have been shown in the literature to be a potential risk factor for ACL graft failure.

Clinical Relevance:
As deep MCL injuries are difficult to detect on physical examination, our findings suggest that the reported MFC edema in ACL ruptures can act as an indirect sign of MFL injury and may aid in the clinical detection. Additionally, due to the anatomical connection of the deep MCL and the meniscocapsular junction of the posterior horn of the medial meniscus, if an MFL injury is suspected through indirect MFC edema at the insertion site, the posterior horn of the medial meniscus should also be assessed for injury, as there is an association between the 2 injuries in ACL ruptures.
Effect of Polar Molecule Aggregation on the Stability of Crude Oil/Water Interface: A Molecular Simulation Study
Authors: Zhao Xinming , Xia Minmin , Li Peng , Wang Jianwei , Xu Yunfei , Guo Shijun 
Published: November 2021

Abstract
To ensure the efficient operation of crude oil dehydration and sewage treatment technology in oilfield surface production system, the effect mechanism of polar components represented by asphaltene and resin on the formation and stability of oil-water emulsion needs to be revealed at nanoscale. In this paper, the molecular dynamics simulation method was used to construct the crude oil/polar component/water system models with different molar ratios of asphaltene to resin by adjusting the number of asphaltene and resin molecules, so as to reveal the molecular arrangement and aggregation process and film forming characteristics of asphaltene, resin, and their mixture at the oil-water interface. The simulated results showed that the aggregation process of asphaltene molecules under the influence of hydrogen bonds can be divided into three stages. The addition of resin molecules enhanced the connection between molecules of all polar components at the interface. The π−π stacking and T-shaped stacking structures were found in all aggregations, and the higher the molar ratio of asphaltene molecules, the higher the proportion of π−π stacking structure. With the increase of the molar ratio of asphaltene to resin increases from 0 : 1 to 1 : 0, the interfacial film thickness and interface formation energy increase from 2.366 nm and -143.89 kJ/mol to 3.796 nm and -304.09 kJ/mol, respectively, which indicated that asphaltene molecules play a more significant role in promoting the formation of interfacial film and maintaining its structural stability than resin molecules. The investigations in this study provide theoretical support for demulsification of the crude oil emulsion.
FBXW2 Inhibits Prostate Cancer Progression and Metastasis Via Promoting EGFR Ubiquitylation and Degradation
Authors: Zhou Tao , Chen Tingting , Lai Bin , Zhang Wenfeng , Luo Xi , Fu Weihua , Zhou Weihua , Xu Jie 
Published: November 2021

Abstract
Background: The process of ubiquitylation, carried out by a three-step enzymatic cascade, maintains the balance of intracellular proteins and the stability of their functions. FBXW2 is a novel F-box protein, and acts as a tumor suppressor gene in lung cancer by directly degrading substrates or regulating the other E3 ligases. However, whether or how FBXW2 regulates prostate cancer (PCa) tumorigenesis and progression is still unclear.Methods: The expression levels of FBXW2 in PCa tissues and matched non-tumor tissues were detected by immunoblotting and qPCR. Cell counting kit-8, wound-healing assay, invasion assay, apoptosis and cell cycle assays, and animal experiments were performed to identify the function of FBXW2 in PCa cells. Half-life analysis, immunoprecipitation, and the in vivo ubiquitylation assay were performed to determine how FBXW2 regulates EGFR and its downstream signaling pathway.Results: FBXW2 expression was lowly expressed in highly-progressive PCa tissues and PCa cell lines. Augmented FBXW2 expression suppressed PCa cell progression and metastasis by repressing EGFR downstream proteins, while FBXW2 depletion had opposite effects. Overexpression of FBXW2 inhibited tumor growth, and even osteolytic bone destruction. Furthermore, FBXW2 and EGFR protein levels were inversely correlated in PCa cell lines and patient tumor tissues. EGFR protein level and its half-life was extended by FBXW2 depletion. While the basal level of EGFR was decreased, and its half-life was shortened upon overexpression of FBXW2-WT but not its dominant negative mutant. Intriguingly, FBXW2 promoted EGFR ubiquitylation and degradation via its binding motif (TSNNST) on EGFR, thereby elevated FBXW2 abrogated the PCa cell growth and metastasis caused by EGF stimulation.Conclusions: Collectively, our data shows that FBXW2 inhibits PCa cell progression and metastasis by promoting EGFR ubiquitylation and degradation, and would be a novel tumor suppressor for PCa.
High Rates of Blood Transfusion Associated with Parkinson’s Disease
Authors: Shahrestani Shane , Tafreshi Ali R. , Brown Nolan , Dashtipour Khashayar 
Published: November 2021

Abstract
ImportanceAs evidence continues to accumulate regarding the multi-organ dysfunction associated with Parkinson’s Disease (PD), it is still unclear as to whether PD increases the risk of hematological pathology. ObjectiveTo investigate the association between PD and hematological pathology and relevant risk factors.Design, Setting, and ParticipantsThis retrospective cohort analysis was conducted using 8-years of the National Readmission Database. All individuals diagnosed with PD were queried at the time of primary admission, and all relevant demographic data was collected. Readmissions, complications, and risk factors were analyzed at 30, 90, 180, and 300-day intervals. Statistical analysis included multivariate gaussian-fitted modelling, with age, sex, comorbidities, and discharge weights as covariates. Coefficients of model variables were exponentiated and interpreted as odds ratios. Predictive models were developed using generalized linear modeling. Complications were queried using International Classification of Disease codes.Main Outcomes and MeasuresReadmission for blood transfusion within readmission intervals and potential risk factors for blood transfusion. ResultsAnalysis was with 1,765,800 PD patients (mean age: 76.3±10.4; 44.1% female). Rates of percutaneous blood transfusion in readmitted patients at 30, 90, 180, and 300 days was found to be 8.7%, 8.6%, 8.3%, and 8.3% respectively. At all timepoints, modelling revealed that those with anti-parkinsonism medication side effects at the primary admission had increased rates of gastrointestinal (GI) hemorrhage (average OR: 1.02; 95%CI: 1.01-1.03, p<0.0001) and blood transfusion (average OR: 1.06; 95%CI: 1.05-1.08, p<0.0001) at readmission. PD patients who experienced GI hemorrhage of any etiology, including as a side effect of anti-parkinsonism medication, were found to have significantly higher rates of blood transfusion at all timepoints (average OR: 1.14; 95%CI: 1.13-1.16, p<0.0001). Kaplan-Meier survival analysis and predictive modelling confirmed these findings, with significantly higher rates of blood transfusion seen in PD patients with drug side effects and GI hemorrhage compared to those without.Conclusions and RelevanceOur findings suggest that PD patients may be readmitted at a high rate for blood transfusion procedures. These readmissions were found to be significantly associated with anti-parkinsonism drug side effects and GI hemorrhage of any etiology. Long-term management of PD patients should focus on both neurological and non-neurological complications.
Nuclear morphology is a deep learning biomarker of senescence across tissues and species
Authors: Heckenbach Indra , Mkrtchyan Garik , Ezra Michael Ben , Bakula Daniela , Madsen Jakob , Nielsen Malte , Oró Denise , Idda M Laura , Gorospe Myriam , Mortensen Laust , Verdin Eric , Westendorp Rudi , Scheibye-Knudsen Morten 
Published: November 2021

Abstract
Cellular senescence is a critical component of aging and many age-related diseases, but understanding its role in human health is challenging in part due to the lack of exclusive or universal markers. Using neural networks, we achieve high accuracy in predicting senescence state and type from the nuclear morphology of DAPI-stained human fibroblasts, murine astrocytes, murine neurons, and fibroblasts derived from premature aging diseases in culture. After generalizing this approach, the predictor recognizes an increasing rate of senescent cells with age in H&E-stained murine liver tissue and human dermal biopsies, suggesting that alterations in nuclear morphology is a universal feature of senescence. Evaluating corresponding medical records reveals that individuals with a higher rate of senescent cells have a significantly decreased rate of malignant neoplasms, lending support for the protective role of senescence in limiting cancer development. Additionally, we find a positive association with lower significance for other conditions, including osteoporosis, osteoarthritis, hypertension, cerebral infarction, hyperlipidemia, and hypercholesteremia. In sum, we introduce a predictor of cellular senescence based on nuclear morphology that is applicable across tissues and species and is associated with health outcomes in humans.
Using Machine Learning to Identify At-risk Students in an Introductory Programming Course
Authors: Cooper Cameron I. , Cooper Kamea J. 
Published: November 2021

Abstract
Nationally, more than one-third of students enrolling in introductory computer science programming courses (CS101) do not succeed. To improve student success rates, this research team used supervised machine learning to identify students who are “at-risk” of not succeeding in CS101 at a two-year public college. The resultant predictive model accurately identifies \(\approx\)99% of “at-risk” students in an out-of-sample test data set. The programming instructor piloted the use of the model’s predictive factors as early alert triggers to intervene with individualized outreach and support across three course sections of CS101 in fall 2020. The outcome of this pilot study was a 23% increase in student success and a 7.3 percentage point decrease in DFW rate. More importantly, this study identified academic, early alert triggers for CS101. Specifically, the first two graded programs are of paramount importance for student success in the course.
Chromatin Reader Dido3 Regulates the Genetic Network of B Cell Differentiation
Authors: Burgo Fernando Gutiérrez del , Pons Tirso , de Luis Enrique Vázquez , Martínez-A Carlos , Villares Ricardo 
Published: November 2021

Abstract
BACKGROUNDThe development of hematopoietic lineages is based on a complex balance of transcription factors whose expression depends on the epigenetic signatures that characterize each differentiation step. The B cell lineage arises from hematopoietic stem cells through the stepwise silencing of stemness genes and balanced expression of mutually regulated transcription factors, as well as DNA rearrangement, in a complex process involving epigenetic remodeling.RESULTSHere we report the impact on B cell differentiation of the lack of DIDO3, a reader of histone post-translational modifications, in the mouse hematopoietic compartment. We found reduced DNA accessibility in hematopoietic precursors, leading to a severe deficiency specifically in the generation of successive stages of B-cell differentiation. The expression of essential transcription factors and differentiation markers is impaired, as is the process of somatic recombination. DIDO3-deficient cells show transcriptional alterations of a number of polycomb repressive complex 2, suggesting the involvement of DIDO3 in determining the specific activity of PRC2 in the B cell lineage, including VH-DJH rearrangement. CONCLUSIONSTaken together, our data suggest that DIDO3 is an epigenetic reader involved in the specific differentiation of B cell precursors in the hematopoietic compartment of mice.
A Case Report of Chronic Expanding Hematoma of the Left Erector Spinae Muscle After Stereotactic Body Radiotherapy for Renal Cell Carcinoma
Authors: Ishikawa Yojiro , Umezawa Rei , Yamamoto Takaya , Takahashi Noriyoshi , Takeda Kazuya , Suzuki Yu , Jingu Keiichi 
Published: November 2021

Abstract
Background: Hematomas that slowly increase in size for over a period of more than one month after the initial hemorrhage are referred to as chronic expanding hematoma (CEH). We report a case of CEH of left erector spinae muscle after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC). Case presentation: A 74-year-old Japanese male complained of back pain. There was no history of surgery or trauma of his back. He received SBRT for RCC of left kidney of seven years ago. Computed tomography (CT) revealed the left erector spinae muscle was swollen compared to the contralateral side at the third lumbar level. Ultrasonography showed a tumor of 30 mm in size without blood flow in left paraspinal muscle. Positron emission tomography-CT revealed uptake in the left paraspinal muscle. Pathological examination showed radiation-induced CEH. We performed conservative therapy with medication alone because the tumor had been gradually growing. One year after starting observation, the patient died due to subdural hemorrhage after a fall and progression of renal failure. Discussion and conclusions: Because this study was a case study, it is difficult to definite the CEH after SBRT. Since SBRT has recently been increasing, SBRT-induced CEH is considered to be an important complication.