bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYCLES OF SOLAR ACTIVITY AS A BASIS FOR FORECASTING THE QUALITY OF DNIEPER WATER
Authors: Kulishenko Oleksiy , Klymenko Natalia 
Published: October 2021

One of the main features of the quality of the Dnieper water is the content of natural organic substances which determine the water oxidizability and color indexes. A special problem is that organic substances are poorly removed by water treatment plants. A significant problem in the operation of water treatment plants is the unpredictability of annual changes in the quality of Dnieper water, which complicates logistics management, for example, the supply of reagents. Many years of experience related to the Dnieper water supply station in Kyiv (DnWS) have led to the hypothesis that these changes are in some way related to the cycles of solar activity.
The purpose of this work is to test this hypothesis to substantiate the possibility of predicting the quality of Dnieper water depending on the action of such a global factor as solar activity. The work was performed by statistical methods using 60-year results of Dnieper water analyzes provided by the DnWS laboratory, as well as Wolf numbers (Sunspot Numbers) provided for free use by the Royal Observatory of Belgium. The influence of solar activity on the quality indicators of Dnieper water, especially in its peak and post-peak periods, has been statistically confirmed. The interaction of biological and physicochemical parameters as factors influencing water quality is shown.
Conclusions. As a result of the construction of six reservoirs in 1931-1976, the Dnieper from the river actually turned into a network of water bodies. Now these reservoirs are a kind of reactors in which water is treated by electromagnetic solar radiation, which leads to the cyclic transformation of phytoplankton and natural organic matter. Taking into account the cycles of solar activity, the logistical planning of the operation of water treatment facilities receives an independent "base", changes in which can be predicted with some reliability for years to come.
Dampak Bantuan Langsung Tunai terhadap Ketahanan Pangan Rumah Tangga di Indonesia
Authors: Amrullah Eka Rastiyanto , Pullaila Ani , Hidayah Ismatul , Rusyiana Aris 
Published: October 2021

<strong>English</strong><br />Direct cash transfer is widely used to strengthen food security and reduce household vulnerability to poverty. In Indonesia, direct cash transfer (BLT) has lasted several decades. However, there are still problems in its implementation. This study aims to analyze the effect of BLT on the food security of household-recipients. The data source used was Susenas March 2015, with a total sample of 285,908 households, comprising 55,238 BLT recipients and 230,670 non-recipients. PSM and IPWRA estimators were used to estimate the ATET indicator of food security. The analysis results showed that BLT positively impacted recipient households in terms of calorie and protein intake per capita/day. BLT also has a positive effect on per capita food expenditure and the share of food expenditure. Besides, BLT impacts a change in the percentage of food expenditure; there is a shift in food consumption from the root crops, animal food, fruit, and vegetables to grains, processed food and beverages, and cigarettes. There has been a change in food consumption patterns in recipient households to become more consumptive. However, providing BLT alone is not enough. It should be combined with other social safety net programs to increase the food security of poor households. <br /><br /><br /><strong>Indonesian</strong><br />Bantuan langsung semakin banyak digunakan untuk memperkuat ketahanan pangan dan mengurangi kerentanan kemiskinan. Di Indonesia, Bantuan Langsung Tunai (BLT) telah berlangsung beberapa dekade. Akan tetapi, dalam pelaksanaannya terdapat beberapa permasalahan, di antaranya ketidaktepatan sasaran. Penelitian ini bertujuan menganalisis dampak program BLT terhadap ketahanan pangan penerima. Sumber data adalah Susenas Maret 2015, dengan sampel 285.908 rumah tangga, terdiri dari 55.238 penerima BLT dan 230.670 bukan penerima. Metode PSM dan IPWRA digunakan untuk menduga ATET indikator ketahanan pangan. Hasil analisis menunjukkan bahwa pemberian BLT memberikan dampak positif bagi rumah tangga penerima dalam aspek asupan kalori dan protein per kapita/hari. BLT juga berdampak positif terhadap pengeluaran pangan per kapita dan pangsa pengeluaran pangan. Selain itu, BLT berdampak pada perubahan pangsa pengeluaran pangan yang ditunjukkan oleh terjadinya pergeseran konsumsi pangan dari kelompok pangan umbi-umbian, pangan hewani, buah dan sayur menuju kelompok padi-padian, makanan dan minuman jadi, serta rokok. Terjadi perubahan pola konsumsi pangan pada rumah tangga penerima menjadi lebih konsumtif. Secara keseluruhan, BLT mampu memberikan dampak positif terhadap beberapa indikator ketahanan pangan. Pemberian BLT saja tidak cukup untuk memberikan makanan yang cukup dan bergizi bagi rumah tangga penerima. Perlu ada kombinasi antara bantuan langsung tunai dengan program jaring pengaman sosial lainnya yang bertujuan untuk meningkatkan ketahanan pangan rumah tangga miskin.
Geomechanical Response Induced by Multiphase (Gas/Water) Flow in the Mallik Hydrate Reservoir of Canada
Authors: Xia Yingli , Xu Tianfu , Yuan Yilong , Xin Xin , Zhu Huixing 
Published: October 2021

Summary
Natural gas hydrate (NGH) is regarded as an important alternative future energy resource. In recent years, a few short-term production tests have been successfully conducted with both permafrost and marine sediments. However, long-term hydrate production performance and the potential geomechanical problems are not very clear. According to the available geological data at the Mallik site, a more realistic hydrate reservoir model that considers the heterogeneity of porosity, permeability, and hydrate saturation was developed and validated by reproducing the field depressurization test. The coupled multiphase and heat flow and geomechanical response induced by depressurization were fully investigated for long-term gas production from the validated hydrate reservoir model. The results indicate that long-term gas production through depressurization from a vertically heterogeneous hydrate reservoir is technically feasible, but the production efficiency is generally modest, with the low average gas production rate of 4.93 × 103 ST m3/d (ST represents the standard conditions) over a 1-year period. The hydrate dissociation region is significantly affected by the reservoir heterogeneity and reveals a heterogeneous dissociation front in the reservoir. The depressurization production results in significant increase of shear stress and vertical compaction in the hydrate reservoir. The response of shear stress indicates that the potential region of sand migration is mainly in the sand-dominant layer during gas production from the hydraulically heterogeneous hydrate reservoir (e.g., sand layers interbedded with clay layers). The maximum subsidence is approximately 78 mm and occurred at the 72nd day, whereas the final subsidence is slowly dropped to 63 mm after 1-year of depressurization production. The vertical subsidence is greatly dependent on the elastic properties and the permeability anisotropy. In particular, the maximum subsidence increased by approximately 81% when the ratio of permeability anisotropy was set at 5:1. Furthermore, the potential shear failure in the hydrate reservoir is strongly correlated to the in-situ stress state. For the normal fault stress regime, the greater the initial horizontal stress is, the less likely the hydrate reservoir is to undergo shear failure during depressurization production.
Rationale and design of the Brazilian Diabetes Study: a prospective cohort of type 2 diabetes
Authors: Barreto Joaquim , Wolf Vaneza , Bonilha Isabella , Luchiari Beatriz , Lima Marcus , Leite Alessandra Oliveira , Vitte Sofia , Machado Gabriela , Cunha Jessica , Borges Cynthia , Munhoz Daniel , Fernandes Vicente , Kimura-Medorima Sheila Tatsumi , Breder Ikaro , Fernandez Marta Duran , Quinaglia Thiago , Oliveira Rodrigo Bueno , Chaves Fernando , Arieta Carlos , Junior Gil Guerra , Avila Sandra , Nadruz Wilson , Carvalho Luiz Sergio Fernandes , Sposito Andrei C 
Published: October 2021

Abstract
Background.
Optimal control of traditional risk factors only partially attenuates the exceeding cardiovascular mortality of individuals with diabetes. Employment of machine learning (ML) techniques aimed at identification of novel features of risk prediction is a compelling target to tackle residual cardiovascular risk.
Objective.
To identify clinical phenotypes of T2D which are more prone for developing cardiovascular disease.
Methods.
The Brazilian Diabetes Study is a single-center, ongoing, prospective registry of T2D individuals. Eligible patients are 30 years-old or older, with a confirmed T2D diagnosis. After an initial visit for signature of informed consent form and medical history registration, all volunteers undergo biochemical analysis, echocardiography, carotid ultrasound, ophthalmologist visit, dual x-ray absorptiometry, coronary artery calcium score, polyneuropathy assessment, advanced glycation end-products reader, and ambulatory blood pressure monitoring. A 5-year follow-up will be conducted by yearly phone interviews for endpoints disclosure. The primary endpoint is the difference between ML-based clinical phenotypes in the incidence of a composite of death, myocardial infarction, revascularization, and stroke. Since June/2016, 1030 patients (mean age: 57 years, diabetes duration of 9.7 years, 58% male) were enrolled in our study. Mean follow-up time was 3.7 years in October/2021.
Conclusions.
The BDS will be the first large population-based cohort dedicated to the identification of clinical phenotypes of T2D at higher risk of cardiovascular events. Data derived from this study will provide valuable information on risk estimation and prevention of cardiovascular and other diabetes-related events.
ClinicalTrials.gov Identifier:
NCT04949152
Investigation of the Potential Serum Levels of Autophagy 5–protein, Apo-Lipoprotein B-48, and Oxidative Stress Markers in the Early Diagnosis of Patients with Ischemic Stroke
Authors: Ajoolabady Amir , Sogutlu Fatma , Nikanfar Masoud , Nourazarian Alireza , Laghousi Delara , shademan behrouz 
Published: October 2021

Abstract
Background: Stroke is one of the leading causes of death worldwide and has different characteristics. Different physiopathological mechanisms characterize the different subtypes of ischemic stroke. In this study, we investigated the correlation between serum levels of autophagy-5 protein, Apo-lipoprotein B-48, and oxidative stress markers in patients with ischemic stroke. Methods and results: We enrolled 100 participants, including 50 ischemic stroke (IS) patients as the case group and 50 healthy individuals as the control group. Then, we conducted a case-control study at Imam Reza Hospital from March 2019 to April 2020. We quantified the serum levels of ATG5, Apo B-48, and oxidative stress markers in both groups. And we evaluated the incremental diagnostic value of these factors by receiver operating characteristic analysis (ROC) in both groups. The mean serum levels of ATG5, Apo B-48, and oxidative stress markers were higher in the case group than in the control group, with a p–value of less than 0.0001 (p <0.0001).Conclusions: Serum levels of ATG5, Apo B-48, Malonaldehyde (MDA), total oxidative stress (TOS), and total antioxidant capacity (TAC) in patients with IS can be used as novel biomarkers to predict or therapeutically modulate patients with IS.
Predictive Modelling Physico-chemical Properties Groundwater in Coastal Plain Area of Vinhlinh and Giolinh Districts of Quangtri Province, Vietnam
Authors: Giang Nguyen Hong , Hieu Tran Dinh , Do Hoang Ngo Tu 
Published: October 2021

Abstract
This paper presents to study the performance of machine learning techniques consisting of Multivariate Adaptive Regression Spline(MARS), Multilayer Perceptron (MLP), and Decision Tree Regression (DTR) for estimating physico-chemical properties groundwater in coastal plain area in Vinhlinh and Giolinh districts of Quangtri province of Vietnam. To deploy the MLP and DTR, different types of transfer and kernel functions were tested, respectively. Determining the results of MARS, MLP and DTR showed that three models have suitable carrying out for forecasting water quality components. Comparison of outcomes of MARS model with MLP, DTR models indicates that this model has good performance for forecasting the elements of water quality, its level of accuracy is slightly more than other. To assess the accurate values of the models according to the measurement parameters indicated that order models were MARS, DTR, and MLP, respectively.
Performance Evaluation of a 4🞩20 Gbps OFDM-based FSO Link Incorporating Hybrid W-MDM Techniques
Authors: Joseph Deepti , Appathurai Karthikeyan , G Kuppusamy P , V Prabhu 
Published: October 2021

Abstract
Free space optics has been envisioned as an crucial technique to meet the high-bandwidth requirements in future wireless information transmission links and a feasible solution to the last-mile bottleneck problem. This research work reports the designing and simulative evaluation of the performance of high-speed orthogonal frequency division multiplexing-based free space optics link by incorporating wavelength division multiplexing of 2 independent frequency channels (193.1 THz and 193.2 THz) along with mode division multiplexing of distinct spatial laser Hermite Gaussian modes (HG01 and HG03). 4 independent 20 Gbps quadrature amplitude modulated data signals are transported simultaneously under different atmospheric weather conditions using the proposed link. Also, the link performance has been investigated for increasing beam divergence angle.
A GIS-based flood risk mapping of Assam, India, using the MCDA-AHP approach at the regional and administrative level
Authors: Gupta Laxmi , Dixit Jagabandhu 
Published: October 2021

Abstract
Floods are hydrological disasters that can alter the physical, socioeconomic, and environmental settings of a region. The objective of the present study is to develop an efficient and reliable methodology to prepare a flood risk map for Assam, the North-eastern region (NER) of India, by the integration of hazard and vulnerability components. Three indices, namely flood hazard index (FHI), flood vulnerability index (FVI), and flood risk index (FRI), are developed using multi-criteria decision analysis (MCDA) – Analytical hierarchy process (AHP) approach in GIS environment for the regional and administrative level of Assam. The selected hazard and vulnerability indicators define the topographical, geological, meteorological, drainage characteristics, land use land cover, and demographical features of Assam. The results show that more than 70% of the total area lies in the moderate to very high FHI class, 57.37% have moderate to high FVI, and more than 50% have moderate to very high FRI class.
A single-cell atlas reveals tumor heterogeneity and immune environment of acral melanoma
Authors: Yang Jilong , Zhang Chao , Shen Hongru , Yang Tielong , Li Ting , Liu Xinyue , Wang Jin , Liao Zhichao , Wei Junqiang , Lu Jia , Liu Haotian , Xiang Lijie , Yang Yichen , Yang Meng , Wang Duan , Li Yang , Xing Ruwei , Teng Sheng , Zhao Jun , Yang Yun , Zhao Gang , Li Xiangchun , Chen Kexin 
Published: October 2021

Abstract
Acral melanoma is a dismal subtype of melanoma occurring at the extremities of dark-skinned people. We performed single-cell RNA sequencing for 63,394 cells obtained from 5 acral and 3 cutaneous melanoma samples to investigate tumor cellular ecosystem particularly the heterogeneity and immune environment. We defined 5 orthogonal cell clusters that were involved in TGF-beta signaling, Type I interferon, Wnt signaling, Cell cycle, and Cholesterol efflux signaling. Signatures of TGF-beta signaling and cholesterol efflux are significantly associated with prognosis of melanoma. Compared with cutaneous melanoma, acral melanoma samples had significantly severe immunosuppressive state including depletion of cytotoxic CD8 + T cells, enrichment of Treg cells, and exhausted CD8 + T cells. PDCD1 (PD-1) and HAVCR2 (TIM-3) had higher expression in the exhaustive CD8 + T cells of acral melanoma. In summary, we have uncovered the tumor heterogeneity and immune infiltration characteristics of acral melanoma. Our findings may help to understand and guide the immunotherapy of acral melanoma.
WITHDRAWN: A Trust-Based Blockchain System for Production and Comprehension of Implicatures by Middle Eastern Speakers of English
Authors: hussein Sami , Mohammadzadeh Behbood 
Published: October 2021

Abstract
This research examined how well Kurdish EFL students interpret and generate implicatures in the same way as native English speakers do. Thus, a multiple-choice discourse completion test and a written discourse completion task were answered by 109 Kurdish EFL university students (42 males and 67 females) and 20 native English speakers (7 males and 13 females).The data were analyzed using SPSS, the Gricean framework (1975), and a rating rubric developed by Jernigan (2007).The results unveiled Kurdish EFL learners have a low level of implicature comprehension as well as production. As opposed to particularized implicatures, participants were more successful in the interpretation of generalized ones. Data showed learners had difficulty understanding conversational implicatures that are context-dependent and sensitive to culture. Data also revealed that transfer of knowledge and mother tongue seem to govern the way in which they comprehend and produce implicatures.Moreover, the findings showed female learners outperformed their male counterparts in the tests. Likewise, private university learners performed better than public university students. Since this examination contains huge amount of data, security is a major concern. Blockchain provides a creative technique to store data, perform functions, and establish trust in an open environment. Hence, the entire analysis is performed in a trust- based blockchain system for the security and privacy of the data.
The Aftermath of Tapering Tocilizumab After Achieving Treatment Target In Patients With Rheumatoid Arthritis: A Nationwide Cohort Study
Authors: Park Jun Won , Kim Min Jung , Kim Hyoun-Ah , Kim Jin Hyun , Lee Eun Bong , Shin Kichul 
Published: October 2021

Abstract
Background: Although recent guidelines recommend that tapering of biologic disease-modifying anti-rheumatic drugs (bDMARDs) can be considered in patients with rheumatoid arthritis (RA), there has been little evidence supporting the strategy during the non-tumor necrosis factor inhibitor treatment. This study aims to investigate the effectiveness and safety of tapering tocilizumab (TCZ) dose in patients with RA who attain low disease activity (LDA) after TCZ therapy in a nationwide cohort.Methods: Data were collected from a nationwide cohort of patients with RA receiving biologic disease-modifying anti-rheumatic drugs in South Korea (KOBIO-RA). This study included 350 patients who were treated with TCZ and achieved Clinical Disease Activity Index-low disease activity (CDAI)-LDA (CDAI ≤ 10) after 1 year of treatment. We performed longitudinal analysis considering clinical data measured at all 1-year intervals for the included patients using the generalized estimating equation. A total of 575 intervals were classified into two groups according to their dose quotient (DQ) of TCZ (tapering group vs. standard-dose group). The main outcome was maintaining CDAI-LDA in the following 1-year interval.Results: Tapering TCZ dose strategy was used in 282 (49.0%) intervals with a mean (SD) DQ of 66.0 (15.5) %. Loss of CDAI-LDA occurred in 91 (15.1%) intervals. Multivariable GEE showed that the tapering group was associated with more frequent failure to sustain CDAI-LDA (adjusted OR [95% CI]: 0.57 [0.33–0.99]), which subsequently led to impaired functional status. The likelihood of achieving DAS28-deep remission (DAS28-ESR<1.98) was also significantly lower in the tapering group (adjusted OR 0.68 [0.46–0.99]). CDAI remission was achieved in only 69 (12.0%) of the total intervals, with no significant difference in the proportion of intervals achieving the target between the two groups. Incidence of adverse events was comparable in both groups except for hypercholesterolemia, which was lower in the tapering group. Conclusions: Tapering TCZ dose after achieving LDA increases the risk of losing LDA without a significant merit in safety.
Adverse Childhood Experiences and Depressive Symptoms Among Female Sexual Minorities in China
Authors: Zhu Biao , Ding Changmian , Wang Liyin , Yan Hong , Jiang Qingqing , Tian Jiawei , Xiao Chenchang , Wei Liqing 
Published: October 2021

Abstract
Background: Despite the relationship between Adverse childhood experiences (ACEs) and depressive symptoms, which has been well conducted in general populations, little is known about homosexual and bisexual populations, especially female sexual minorities in China. This study aims to investigate the prevalence of ACEs and depressive symptoms and to analyze the relationship between them among female sexual minorities in China.Methods: The eligible participants were aged 16 years or older who report their sexual orientation as homosexual or bisexual. The data was collected through anonymous questionnaires under the help of Lespark in Bejing from July 18 to December 29, 2018. Univariate analysis and multiple linear regression analyses were performed to explore the relationship between ACEs and depressive symptoms among female sexual minorities. All statistical analyses were conducted by the software of SPSS 22.0.Results: Among 301 female sexual minorities,51.5% reported at least one ACE, in which emotional neglect (22.6%) and emotional abuse (22.3%) were common ACEs. 24.6% reported that they had suffered only one type of ACE, and 10% have suffered four or more ACEs. As for depressive symptoms of female sexual minorities, the detection rate was 56.1%. The multiple linear regression analyses showed that abuse (β=2.95, p＜0.05) and neglect (β=3.21,p＜0.05) were positively correlated with depressive symptoms and female sexual minorities with three (β=4.11, p＜0.05) or more (β=6.02, p＜0.001) ACEs suffered from more depressive symptoms than others. Conclusion: Both ACEs and depressive symptoms were at high prevalence among female sexual minorities in China. ACEs were associated with depressive symptoms, especially childhood abuse and neglect experiences that have a significant effect on female sexual minorities’ mental health.