bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroprevalence of COVID-19 infection in the Emirate of Abu Dhabi, United Arab Emirates: a population-based cross-sectional study
Authors: Alsuwaidi Ahmed R , Al Hosani Farida I , Al Memari Shammah , Narchi Hassib , Abdel Wareth Laila , Kamal Hazem , Al Ketbi Mai , Al Baloushi Durra , Elfateh Abubaker , Khudair Ahmed , Al Mazrouei Shereena , Al Humaidan Hiba Saud , Alghaithi Noura , Afsh Khalil , Al Kaabi Nawal , Altrabulsi Basel , Jones Matthew , Shaban Sami , Sheek-Hussein Mohamud , Zoubeidi Taoufik 
Published: March 2021

Abstract

Background
The United Arab Emirates (UAE) was the first country in the Middle East to report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Serosurveys are essential to understanding the extent of virus transmission. This cross-sectional study aims to assess the seroprevalence of SARS-CoV-2 infection in the Emirate of Abu Dhabi.

Methods
Between 19 July and 14 August 2020, 4487 households were selected using a random sample stratified by region and citizenship of the head of household (UAE citizen or non-citizen). A cluster sample of 40 labour camps was selected. Data on socio-demographic characteristics, risk factors and symptoms compatible with coronavirus disease 2019 (COVID-19) were collected. Each participant was first tested by Roche Elecsys® Anti-SARS-CoV-2 assay, followed, when reactive, by the LIAISON® SARS-CoV-2 S1/S2 IgG assay.

Results
Among 8831 individuals from households, seroprevalence was 10·4% [95% confidence intervals (CIs) 9·5–11·4], with higher seroprevalence in Abu Dhabi and Al Ain regions compared with those in Al Dhafra. In households, we found no sex difference and UAE citizens had lower seroprevalence compared with those of other nationalities. Among 4855 workers residing in labour camps, seroprevalence was 68·6% (95% CI 61·7–74·7), with higher seroprevalence among workers from Southeast Asia. In households, individuals with higher body mass indexes demonstrated higher seroprevalences than individuals with normal weight. Anosmia and ageusia were strongly associated with seropositivity.

Conclusions
The majority of household populations in the Emirate of Abu Dhabi remained unexposed to SARS-CoV-2. In labour camps, SARS-CoV-2 transmission was high. Effective public health measures should be maintained.
Intercontinental prediction of soybean phenology via hybrid ensemble of knowledge-based and data-driven models
Authors: McCormick Ryan F , Truong Sandra K , Rotundo Jose , Gaspar Adam P , Kyle Don , van Eeuwijk Fred , Messina Carlos D 
Published: March 2021

AbstractABSTRACTThe timing of crop development has significant impacts on management decisions and subsequent yield formation. A large intercontinental dataset recording the timing of soybean developmental stages was used to establish ensembling approaches that leverage both knowledge-based, human-defined models of soybean phenology and data-driven, machine-learned models to achieve accurate and interpretable predictions. We demonstrate that the knowledge-based models can improve machine learning by generating expert-engineered features. The collection of knowledge-based and data-driven models was combined via super learning to both improve prediction and identify the most performant models. Stacking the predictions of the component models resulted in a mean absolute error of 4.41 and 5.27 days to flowering (R1) and physiological maturity (R7), providing an improvement relative to the benchmark knowledge-based model error of 6.94 and 15.53 days, respectively, in cross-validation. The hybrid intercontinental model applies to a much wider range of management and temperature conditions than previous mechanistic models, enabling improved decision support as alternative cropping systems arise, farm sizes increase and changes in the global climate continue to accelerate.
Characteristics of fosA-carrying plasmids in E. coli and Klebsiella spp. isolates originating from food and environmental samples
Authors: Biggel Michael , Zurfluh Katrin , Treier Andrea , Nüesch-Inderbinen Magdalena , Stephan Roger 
Published: March 2021

Abstract

Objectives
Fosfomycin is an important antibiotic for the treatment of MDR Enterobacteriaceae infections. High susceptibility rates are, however, threatened by the spread of plasmids encoding fosfomycin-modifying enzymes. In this study, we sought to characterize the genetic context of fosA in plasmids from Escherichia coli and Klebsiella spp. isolates recovered from food, wastewater and surface water in Switzerland.

Methods
E. coli and Klebsiella spp. isolates collected between 2012 and 2019 in Switzerland were screened for fosfomycin resistance. Presence of fosA was verified by PCR and sodium phosphonoformate (PPF) disc potentiation testing, and transferability was tested using conjugation assays. Whole-genome sequences including complete fosA-containing plasmids were determined using long- and short-read sequencing.

Results
In 11 E. coli and two Klebsiella spp. isolates, high-level fosfomycin resistance was mediated by plasmids containing fosA3 (n = 12) or fosA8 (n = 1). Four isolates harboured a near-identical 45 kb IncN plasmid with fosA3, while replicon types varied in the remaining plasmids. The fosA genes were typically embedded in IS26-bounded transposition units and frequently located in the proximity of blaCTX-M transposition units.

Conclusions
Although fosfomycin resistance rates are currently low, the presence of fosA-encoding plasmids circulating in the Enterobacteriaceae population suggests that fosfomycin resistance may rapidly spread upon increased selection pressure. Transposition mobility of fosA and co-location on plasmids with other resistance genes may further promote its dissemination.
Combined effects of 3-nitrooxypropanol and canola oil supplementation on methane emissions, rumen fermentation and biohydrogenation, and total tract digestibility in beef cattle
Authors: Zhang Xiu Min , Smith Megan L , Gruninger Robert J , Kung Limin , Vyas Diwakar , McGinn Sean M , Kindermann Maik , Wang Min , Tan Zhi Liang , Beauchemin Karen A 
Published: March 2021

Abstract
The individual and combined effects of 3-nitrooxypropanol (3-NOP) and canola oil (OIL) supplementation on enteric methane (CH4) and hydrogen (H2) emissions, rumen fermentation and biohydrogenation, and total tract nutrient digestibility were investigated in beef cattle. Eight beef heifers (mean body weight ± SD, 732 ± 43 kg) with ruminal fistulas were used in a replicated 4 × 4 Latin square with a 2 (with and without 3-NOP) × 2 (with and without OIL) arrangement of treatments and 28-d periods (13 d adaption and 15 d measurements). The four treatments were: control (no 3-NOP, no OIL), 3-NOP (200 mg/kg dry matter [DM]), OIL (50 g/kg DM), and 3-NOP (200 mg/kg DM) plus OIL (50 g/kg DM). Animals were fed restrictively (7.6 kg DM/d) a basal diet of 900 g/kg DM barley silage and 100 g/kg DM supplement. 3-NOP and OIL decreased (P &lt; 0.01) CH4 yield (g/kg DM intake) by 31.6% and 27.4%, respectively, with no 3-NOP × OIL interaction (P = 0.85). Feeding 3-NOP plus OIL decreased CH4 yield by 51% compared with control. There was a 3-NOP × OIL interaction (P = 0.02) for H2 yield (g/kg DM intake); the increase in H2 yield (P &lt; 0.01) due to 3-NOP was less when it was combined with OIL. There were 3-NOP × OIL interactions for molar percentages of acetate and propionate (P &lt; 0.01); individually, 3-NOP and OIL decreased acetate and increased propionate percentages with no further effect when supplemented together. 3-NOP slightly increased crude protein (P = 0.02) and starch (P = 0.01) digestibilities, while OIL decreased the digestibilities of DM (P &lt; 0.01) and neutral detergent fiber (P &lt; 0.01) with no interactions (P = 0.15 and 0.10, respectively). 3-NOP and OIL increased (P = 0.04 and P &lt; 0.01, respectively) saturated fatty acid concentration in rumen fluid, with no interaction effect. Interactions for ruminal trans-monounsaturated fatty acids (t-MUFA) concentration and percentage were observed (P = 0.02 and P &lt; 0.01); 3-NOP had no effect on t-MUFA concentration and percentage, while OIL increased the concentration (P &lt; 0.01) and percentage (P &lt; 0.01) of t-MUFA but to a lesser extent when combined with 3-NOP. In conclusion, the CH4-mitigating effects of 3-NOP and OIL were independent and incremental. Supplementing ruminant diets with a combination of 3-NOP and OIL may help mitigate CH4 emissions, but the decrease in total tract digestibility due to OIL may decrease animal performance and needs further investigation.
Molecular Signatures of Chromosomal Instability Correlate With Copy Number Variation Patterns and Patient Outcome in IDH-Mutant and IDH-Wildtype Astrocytomas
Authors: Richardson Timothy E , Sathe Adwait Amod , Xing Chao , Mirchia Kanish , Viapiano Mariano S , Snuderl Matija , Abdullah Kalil G , Hatanpaa Kimmo J , Walker Jamie M 
Published: March 2021

Abstract
Chromosomal instability due to mutations in genes guarding the stability of the genome is a well-known mechanism underlying tumorigenesis and malignant progression in numerous cancers. The effect of this process in gliomas is mostly unknown with relatively little research examining the effects of chromosomal instability on patient outcome and therapeutic efficacy, although studies have shown that overall/total copy number variation (CNV) is elevated in higher histologic grades and in cases with more rapid progression and shorter patient survival. Herein, we examine a 70-gene mRNA expression signature (CIN70), which has been previously shown to correlate tightly with chromosomal instability, in 2 independent cohorts of IDH-mutant astrocytomas (total n = 241), IDH-wildtype astrocytomas (n = 228), and oligodendrogliomas (n = 128). Our results show that CIN70 expression levels correlate with total CNV, as well as higher grade, progression-free survival, and overall survival in both IDH-mutant and IDH-wildtype astrocytomas. In oligodendrogliomas, these mRNA signatures correlate with total CNV but not consistently with clinical outcome. These data suggest that chromosomal instability is an underlying factor in aggressive behavior and progression of a subset of diffuse astrocytomas. In addition, chromosomal instability may in part explain the poor response of diffuse gliomas to treatment and may serve as a future therapeutic target.
Charles Ives and the Lied: Modelling in Ives’s Early German Song Repertory
Authors: Kint Thomas 
Published: March 2021

Abstract
Existing scholarship has not given extensive attention to Ives’s German songs. Scholars have long assumed that Ives used specific earlier settings of the same texts as models for his songs, and that he wrote all of his German songs as assignments for Horatio Parker. However, neither of these claims has been proved. This article explores Ives’s deep commitment to mastering different aspects of the European Romantic tradition as a young composer. By analysing the five songs composed to texts of Heinrich Heine, it reinforces the hypothesis that Ives systematically modelled his songs on earlier settings. Yet, it also demonstrates how the wrong models have often been suggested in the past. More than previously assumed, interpretative textual analysis of these songs shows that Ives modelled his songs not only in terms of musical technique and detail but also in his response to the poetic text.
Bayesian constraints on the origin and geology of exoplanetary material using a population of externally polluted white dwarfs
Authors: Harrison John H D , Bonsor Amy , Kama Mihkel , Buchan Andrew M , Blouin Simon , Koester Detlev 
Published: March 2021

ABSTRACT
White dwarfs that have accreted planetary bodies are a powerful probe of the bulk composition of exoplanetary material. In this paper, we present a Bayesian model to explain the abundances observed in the atmospheres of 202 DZ white dwarfs by considering the heating, geochemical differentiation, and collisional processes experienced by the planetary bodies accreted, as well as gravitational sinking. The majority (&gt;60 per cent) of systems are consistent with the accretion of primitive material. We attribute the small spread in refractory abundances observed to a similar spread in the initial planet-forming material, as seen in the compositions of nearby stars. A range in Na abundances in the pollutant material is attributed to a range in formation temperatures from below 1000 K to higher than 1400 K, suggesting that pollutant material arrives in white dwarf atmospheres from a variety of radial locations. We also find that Solar System-like differentiation is common place in exoplanetary systems. Extreme siderophile (Fe, Ni, or Cr) abundances in eight systems require the accretion of a core-rich fragment of a larger differentiated body to at least a 3σ significance, whilst one system shows evidence that it accreted a crust-rich fragment. In systems where the abundances suggest that accretion has finished (13/202), the total mass accreted can be calculated. The 13 systems are estimated to have accreted masses ranging from the mass of the Moon to half that of Vesta. Our analysis suggests that accretion continues for 11 Myrs on average.
Partial tidal disruption events by stellar mass black holes: Gravitational instability of stream and impact from remnant core
Authors: Wang Yi-Han , Perna Rosalba , Armitage Philip J 
Published: March 2021

ABSTRACT
In dense star clusters, such as globular and open clusters, dynamical interactions between stars and black holes (BHs) can be extremely frequent, leading to various astrophysical transients. Close encounters between a star and a stellar mass BH make it possible for the star to be tidally disrupted by the BH. Due to the relative low mass of the BH and the small cross-section of the tidal disruption event (TDE) for cases with high penetration, disruptions caused by close encounters are usually partial disruptions. The existence of the remnant stellar core and its non-negligible mass compared to the stellar mass BH alters the accretion process significantly. We study this problem with SPH simulations using the code Phantom, with the inclusion of radiation pressure, which is important for small mass BHs. Additionally, we develop a new, more general method of computing the fallback rate which does not rely on any approximation. Our study shows that the powerlaw slope of the fallback rate has a strong dependence on the mass of the BH in the stellar mass BH regime. Furthermore, in this regime, self-gravity of the fallback stream and local instabilities become more significant, and cause the disrupted material to collapse into small clumps before returning to the BH. This results in an abrupt increase of the fallback rate, which can significantly deviate from a powerlaw. Our results will help in the identification of TDEs by stellar mass BHs in dense clusters.
Tidal dissipation impact on the eccentric onset of common envelope phases in massive binary star systems
Authors: Vick Michelle , MacLeod Morgan , Lai Dong , Loeb Abraham 
Published: March 2021

ABSTRACT
Tidal dissipation due to turbulent viscosity in the convective regions of giant stars plays an important role in shaping the orbits of pre-common-envelope systems. Such systems are possible sources of transients and close compact binary systems that will eventually merge and produce detectable gravitational wave signals. Most previous studies of the onset of common envelope episodes have focused on circular orbits and synchronously rotating donor stars under the assumption that tidal dissipation can quickly spin-up the primary and circularize the orbit before the binary reaches Roche lobe overflow (RLO). We test this assumption by coupling numerical models of the post-main-sequence stellar evolution of massive stars with the model for tidal dissipation in convective envelopes developed in Vick & Lai – a tidal model that is accurate even for highly eccentric orbits with small pericentre distances. We find that, in many cases, tidal dissipation does not circularize the orbit before RLO. For a $10\, {\rm M}_{\odot }$ ($15\, {\rm M}_{\odot }$) primary star interacting with a $1.4\, {\rm M}_{\odot }$ companion, systems with pericentre distances within 3 au (6 au) when the primary leaves the main sequence will retain the initial orbital eccentricity when the primary grows to the Roche radius. Even in systems that tidally circularize before RLO, the donor star may be rotating subsynchronously at the onset of mass transfer. Our results demonstrate that some possible precursors to double neutron star systems are likely eccentric at the Roche radius. The effects of pre-common-envelope eccentricity on the resulting compact binary merit further study.
Metallicities from high-resolution spectra of 49 RR Lyrae variables
Authors: Gilligan Christina K , Chaboyer Brian , Marengo Massimo , Mullen Joseph P , Bono Giuseppe , Braga Vittorio F , Crestani Juliana , Dall’Ora Massimo , Fiorentino Giuliana , Monelli Matteo , Neeley Jill R , Fabrizio Michele , Martínez-Vázquez Clara E , Thévenin Frédéric , Sneden Christopher 
Published: March 2021

ABSTRACT
Accurate metallicities of RR Lyrae are extremely important in constraining period–luminosity–metallicity (PLZ) relationships, particularly in the near-infrared. We analyse 69 high-resolution spectra of Galactic RR Lyrae stars from the Southern African Large Telescope. We measure metallicities of 58 of these RR Lyrae stars with typical uncertainties of 0.15 dex. All but one RR Lyrae in this sample has accurate ($\sigma _{\varpi }\lesssim 10{{\ \rm per\ cent}}$) parallax from Gaia. Combining these new high-resolution spectroscopic abundances with similar determinations from the literature for 93 stars, we present new PLZ relationships in WISE W1 and W2 magnitudes, and the Wesenheit magnitudes W(W1, V − W1) and W(W2, V − W2).
RbAp46/48LIN-53 and HAT-1 are required for initial CENP-AHCP-3 deposition andde novoholocentromere formation on artificial chromosomes inCaenorhabditis elegansembryos
Authors: Lin Zhongyang , Yuen Karen Wing Yee 
Published: March 2021

AbstractForeign DNA microinjected into the Caenorhabditis elegans syncytial gonad forms episomal extra-chromosomal arrays, or artificial chromosomes (ACs), in embryos. Short, linear DNA fragments injected concatemerize into high molecular weight (HMW) DNA arrays that are visible as punctate DAPI-stained foci in oocytes, and they undergo chromatinization and centromerization in embryos. The inner centromere, inner kinetochore and spindle checkpoint components, including AIR-2, CENP-AHCP-3, Mis18BP1KNL-2 and BUB-1, respectively, assemble onto the nascent ACs during the first mitosis. The DNA replication efficiency of ACs improves over several cell cycles, which correlates with the improvement of kinetochore bi-orientation and proper segregation of ACs. Depletion of condensin II subunits, like CAPG-2 and SMC-4, but not the replicative helicase component, MCM-2, reduces de novo CENP-AHCP-3 level on nascent ACs. Furthermore, H3K9ac, H4K5ac and H4K12ac are highly enriched on newly chromatinized ACs. RbAp46/48LIN-53 and HAT-1, which affect the acetylation of histone H3 and H4, are essential for chromatinization, de novo centromere formation and segregation competency of nascent ACs. RbAp46/48LIN-53 or HAT-1 depletion causes the loss of both CENP-AHCP-3 and Mis18BP1KNL-2 initial deposition at de novo centromeres on ACs. This phenomenon is different from centromere maintenance on endogenous chromosomes, where Mis18BP1KNL-2 functions upstream of RbAp46/48LIN-53.
Language Gap in Reach of “The Real Cost”: Examination of a Federal Mass Media Campaign From 2017 to 2019
Authors: Mantey Dale S , Clendennen Stephanie L , Ruiz Felisa A , Perry Cheryl L 
Published: March 2021

Abstract

Introduction
Approximately 25% of youth in the United States speak a language other than English at home. These youth may have less exposure to English-speaking media, including public smoking prevention initiatives such as the FDA’s “The Real Cost” campaign. Research is needed to explore potential gaps in the reach of “The Real Cost” campaign among bilingual youth.

Aims and Methods
Data were pooled from the 2017–2019 National Youth Tobacco Surveys. Participants were n = 12 803 middle and high school students who were either: (1) susceptible never smokers; or (2) ever smokers that had smoked less than 100 cigarettes; these criteria reflect the FDA’s definition of “target population” for “The Real Cost” campaign. Multiple, logistic regression analyses examined the relationship between speaking a language other than English at home (ie, bilingual) and self-reported exposure to “The Real Cost” campaign among both samples. Analyses controlled for sex, race/ethnicity, grade level, tobacco marketing exposure, and current tobacco use.

Results
The majority (61.7%) of youth who met “target population” criteria self-reported exposure to “The Real Cost” from 2017 to 2019. Regression analyses found that youth who reported speaking a language other than English at home were significantly less likely to self-report exposure to “The Real Cost” campaign (adjusted odds ratio: 0.85; p &lt; .001), adjusting for covariates.

Conclusions
Bilingual youth were significantly less likely to report exposure to “The Real Cost” campaign. Findings suggest the need to develop methods of increasing reach among bilingual youth, given the high smoking prevalence among these youth.

Implications
This study highlights a social and cultural gap in the reach of the FDA’s “The Real Cost” campaign. Agencies such as FDA should consider enhancing existing mass media campaigns to reach diverse communities, including the nearly 25% of youth who speak a language other than English.