bluuebunny/crossref_metadata_2025_split huggingface dataset:
LBP‐based progressive feature aggregation network for low‐light image enhancement
Authors: Yu Nana , Li Jinjiang , Hua Zhen 
Published: November 2021

AbstractAt night or in other low‐illumination environments, optical imaging devices cannot capture details and color information in images accurately because of the reduced number of photons captured and the low signal‐to‐noise ratio. Consequently, the image is very noisy with low contrast and inaccurate color information, which affects human visual perception and creates significant challenges in computer vision tasks. Low‐light image enhancement has great research value because it aims to reduce image noise and improve image quality. In this study, we propose an LBP‐based progressive feature aggregation network (P‐FANet) for low‐light image enhancement. The LBP feature has insensitivity to illumination, and it contains rich texture information. In the network, we input the LBP feature into each iteration of the network in an accompanying manner, which helps to restore some detailed information of the low‐light image. First, we input the low‐light image into the dual attention mechanism model to extract global features. Second, the extracted different features enter the feature aggregation module (FAM) for feature fusion. Third, we use the recurrent layer to share the features extracted at different stages, and use the residual layer to further extract deeper features. Finally, the enhanced image is output. The rationality of the method in this study has been verified through ablation experiments. Many experimental results show that the method in this study has greater advantages in subjective and objective evaluations compared with many other advanced methods.
Identification of the key genes and immune infiltrating cells determined by sex differences in ischaemic stroke through co‐expression network module
Authors: Xu Haipeng , Ge Yanzhi , Liu Yang , Zheng Yang , Hu Rong , Ren Conglin , Liu Qianqian 
Published: November 2021

AbstractStroke is one of the leading causes of patients' death and long‐term disability worldwide, and ischaemic stroke (IS) accounts for nearly 80% of all strokes. Differential genes and weighted gene co‐expression network analysis (WGCNA) in male and female patients with IS were compared. The authors used cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT) to analyse the distribution pattern of immune subtypes between male and female patients. In this study, 141 up‐regulated and 61 down‐regulated genes were gathered and distributed into five modules in response to their correlation degree to clinical traits. The criterion for Gene Ontology (GO) term and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway indicated that detailed analysis had the potential to enhance clinical prediction and to identify the gender‐related mechanism. After that, the expression levels of hub genes were measured via the quantitative real‐time PCR (qRT‐PCR) method. Finally, CCL20, ICAM1 and PTGS2 were identified and these may be some promising targets for sex differences in IS. Besides, the hub genes were further verified by rat experiments. Furthermore, these CIBERSORT results showed that T cells CD8 and Monocytes may be the target for the treatment of male and female patients, respectively.
The BINGO project
Authors: Wuensche Carlos A. , Villela Thyrso , Abdalla Elcio , Liccardo Vincenzo , Vieira Frederico , Browne Ian , Peel Michael W. , Radcliffe Christopher , Abdalla Filipe B. , Marins Alessandro , Barosi Luciano , Brito Francisco A. , Queiroz Amilcar R. , Wang Bin , Costa Andre A. , Ferreira Elisa G. M. , Fornazier Karin S.F. , Landim Ricardo G. , Novaes Camila P. , Santos Larissa , dos Santos Marcelo V. , Zhang Jiajun , Chen Tianyue , Delabrouille Jacques , Dickinson Clive , de Gasperis Giancarlo , Gurjão Edmar C. , Harper Stuart , Ma Yin-Zhe , Machado Telmo , Maffei Bruno , de Mericia Eduardo J. , Monstein Christian , Motta Pablo , Otobone Carlos H. N. , Reitano Luiz A. , Remazeilles Mathieu , Roychowdhury Sambit , Santos João R. L. , Serres Alexandre J. R. , Souza Andreia P. , Strauss Cesar , Vieira Jordany , Xu Haiguang 
Published: November 2021

Context.The measurement of diffuse 21-cm radiation from the hyperfine transition of neutral hydrogen (H Isignal) in different redshifts is an important tool for modern cosmology. However, detecting this faint signal with non-cryogenic receivers in single-dish telescopes is a challenging task. The BINGO (Baryon Acoustic Oscillations from Integrated Neutral Gas Observations) radio telescope is an instrument designed to detect baryonic acoustic oscillations (BAOs) in the cosmological H Isignal, in the redshift interval 0.127 ≤ z ≤ 0.449.Aims.This paper describes the BINGO radio telescope, including the current status of the optics, receiver, observational strategy, calibration, and the site.Methods.BINGO has been carefully designed to minimize systematics, being a transit instrument with no moving dishes and 28 horns operating in the frequency range 980 ≤ ν ≤ 1260 MHz. Comprehensive laboratory tests were conducted for many of the BINGO subsystems and the prototypes of the receiver chain, horn, polarizer, magic tees, and transitions have been successfully tested between 2018–2020. The survey was designed to cover ∼13% of the sky, with the primary mirror pointing at declinationδ = −15°. The telescope will see an instantaneous declination strip of 14.75°.Results.The results of the prototype tests closely meet those obtained during the modeling process, suggesting BINGO will perform according to our expectations. After one year of observations with a 60% duty cycle and 28 horns, BINGO should achieve an expected sensitivity of 102 μK per 9.33 MHz frequency channel, one polarization, and be able to measure the H Ipower spectrum in a competitive time frame.
Gravitational atmospheric tides as a probe of Titan’s interior: Application to Dragonfly
Authors: Charnay B. , Tobie G. , Lebonnois S. , Lorenz R. D. 
Published: November 2021

Context.Saturn’s massive gravity is expected to causes a tide in Titan’s atmosphere, producing a surface pressure variation through the orbit of Titan and tidal winds in the troposphere. The future Dragonfly mission could analyse this exotic meteorological phenomenon.Aims.We aim to analyse the effect of Saturn’s tides on Titan’s atmosphere and interior to determine how pressure measurements by Dragonfly could constrain Titan’s interior.Methods.We model atmospheric tides with analytical calculations and with a 3D global climate model (the IPSL-Titan GCM), including the tidal response of the interior.Results.We predict that the Love numbers of Titan’s interior should verify 1 +ℜ(k2−h2) ~ 0.02–0.1 andℑ(k2−h2) < 0.04. The deformation of Titan’s interior should therefore strongly weaken gravitational atmospheric tides, yielding a residual surface pressure amplitude of only ~5 Pa, with a phase shift of 5–20 h. Tidal winds are very weak, of the order of 3 × 10−4m s−1in the lower troposphere. Finally, constraints from Dragonfly data may permit the real and the imaginary parts ofk2−h2to be estimated with a precision of ±0.01–0.03.Conclusions.Measurements of pressure variations by Dragonfly over the whole mission could give valuable constraints on the thickness of Titan’s ice shell, and, via geophysical models, its heat flux and the density of its internal ocean.
Editorial
Authors: Rauner Martina 
Published: November 2021

Liebe Freunde der Osteologie, liebe Kolleginnen und Kollegen,Das Fachgebiet der Osteoimmunologie beschäftigt sich mit den
Interaktionen des Immunsystems mit dem Knochen. Bereits in den 1990ern, kurz
nach der Entdeckung von RANKL, dem Schlüsselprotein zur Differenzierung
von Osteoklasten, etablierte sich dieses Themengebiet innerhalb der Osteologie.
Schon damals hatte man erkannt, dass RANKL nicht nur von Osteoblasten produziert
und für die Kommunikation zu Osteoklasten verwendet wird, sondern auch
von aktivierten T-Zellen, die so zur vermehrten Generation von Osteoklasten und
damit zum Knochenabbau im Kontext der chronischen Entzündung beitragen
können. Somit ist die Osteoimmunologie klinisch von hoher Relevanz.
Liver metastasis mimicking a liver cyst of a thymoma in a 38-year-old immunocompromised patient
Authors: Petzold Golo , Ströbel Philipp , Seif Amir Hosseini Ali , Ellenrieder Volker , Neesse Albrecht 
Published: November 2021

AbstractCystic liver lesions (CLL) are common and, in the majority of cases, benign. However, the range of differential diagnoses of CLL is wide. A combination of medical history, blood test results, and imaging can help find the correct diagnosis. We report the case of a 38-year-old immunocompromised female patient with a history of thymectomy and postoperative radiation 3 years prior due to thymoma. Subsequently, the patient was referred to our department for clarification of a cystic liver lesion. During short-term follow-up, the lesion increased in size, and due to the contrast agent behavior in the ultrasound and MRI examination, the suspicion of a biliary cystadenocarcinoma was considered.Furthermore, imaging showed several subcentimetric liver lesions of unknown dignity. Finally, pericystectomy and atypical partial liver resection was performed. Histology revealed a cystic metastasis of the malignant B3 thymoma and a cavernous hemangioma. Liver metastases of a thymoma are rare, and this is the first case of a cystic liver metastasis of a thymoma. The presented case illustrates that in the management of CLLs beside imaging techniques, the medical history with previous conditions should be considered, especially in past malignancies.
Fibroblast-like Synoviocytes – Actors in Osteoimmunology
Authors: Beckmann Denise , Korb-Pap Adelheid , Wehmeyer Corinna 
Published: November 2021

AbstractRheumatoid arthritis (RA) is an immune mediated inflammatory disease (IMID),
characterized by chronic inflammation and irreversible bone loss. Studies have
shown that fibroblast-like synoviocytes (FLS), a key cell population in the
pathogenesis of RA, have an impact on balancing bone-forming osteoblasts and
bone-destroying osteoclasts towards joint damage. Once activated, RA-FLS are
able to destroy cartilage and subchondral bone through the release of RANKL,
members of the metalloproteinase family and many more cytokines, chemokines and
growth factors. Additionally, RA-FLS are responsible for the perpetuation and
chronicity of the disease due the interaction with immune cells supporting the
influx of T and B lymphocytes, monocytes, macrophages neutrophils and dendritic
cells from the blood stream into the inflamed synovial tissue. In this review we
highlight the direct and indirect impact of synovial fibroblasts in RA on joint
damage and disease progression. Moreover, we describe mechanisms of synovitis
and regulators of bone homeostasis in further inflammatory joint diseases such
as ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and compare them to
RA.
Beyond the Psychoactive Effects of Ayahuasca: Cultural and Pharmacological Relevance of Its Emetic and Purging Properties
Authors: Politi Matteo , Tresca Giorgia , Menghini Luigi , Ferrante Claudio 
Published: November 2021

AbstractThe herbal preparation ayahuasca has been an important part of ritual and healing practices, deployed to access invisible worlds in several indigenous groups in the Amazon basin and among mestizo populations of South America. The preparation is usually known to be composed of two main plants, Banisteriopsis caapi and Psychotria viridis, which produce both hallucinogenic and potent purging and emetic effects; currently, these are considered its major pharmacological activities. In recent decades, the psychoactive and visionary effect of ayahuasca has been highly sought after by the shamanic tourism community, which led to the popularization of ayahuasca use globally and to a cultural distancing from its traditional cosmological meanings, including that of purging and emesis. Further, the field of ethnobotany and ethnopharmacology has also produced relatively limited data linking the phytochemical diversity of ayahuasca with the different degrees of
its purging and emetic versus psychoactive effects. Similarly, scientific interest has also principally addressed the psychological and mental health effects of ayahuasca, overlooking the cultural and pharmacological importance of the purging and emetic activity. The aim of this review is therefore to shed light on the understudied purging and emetic effect of ayahuasca herbal preparation. It firstly focuses on reviewing the cultural relevance of emesis and purging in the context of Amazonian traditions. Secondly, on the basis of the main known phytochemicals described in the ayahuasca formula, a comprehensive pharmacological evaluation of their emetic and purging properties is presented.
Validation of a Brochure to Guide Health Professionals in the Dressing and Undressing of Personal Protective Equipment During the SARS-CoV-2 Pandemic
Authors: Salomé Geraldo Magela , Miranda Flávio Dutra 
Published: November 2021

Abstract
Objective To develop and validate a brochure to guide health professionals in properly dressing and undressing the personal protective equipment (PPE) used in the SARS-CoV-2 pandemic.
Methods To develop the brochure, an integrative literature review was conducted after searching the following databases: SciELO, LILACS, and MEDLINE. The brochure was evaluated by 38 health professionals (nurses, physical therapists, and doctors) employing the Delphi technique. The results were analyzed using the Content Validity Index.
Results In the first evaluation cycle, the items in the brochure were considered by the panel of experts as ranging from “unsuitable” to “totally adequate”. After the appropriate corrections suggested by the experts, the brochure once again was sent to the second evaluation cycle, in which all items were rated as “adequate” or “totally adequate.” The result is a Content Validity Index of 1.0.
Conclusion The present study allowed the development of a brochure and its validation by consensus among the evaluation group. The developed and validated brochure presents the reliability of the technique of dressing and undressing the PPE used by health professionals during the pandemic of COVID-19. This information contributes to the management of assistance with quality and safety for the frontline workers and patients.
IDH Wild-type Glioblastoma Presenting with Seizure: Clinical Specificity, and Oncologic and Surgical Outcomes
Authors: Pesce Alessandro , Armocida Daniele , Paglia Francesco , Palmieri Mauro , Frati Alessandro , D'Andrea Giancarlo , Salvati Maurizio , Santoro Antonio 
Published: November 2021

AbstractBackground Glioblastoma (GBM) is the most common and aggressive primary brain neoplasia in adults. Seizure is a common manifestation in GBM. Up to 25 to 60% of patients with GBM have seizures. We aim to summarize all the relevant clinical, surgical, radiologic, and molecular features of a cohort of patients suffering from GBM-related epilepsy and measure the outcome, to understand the possible existence of a clinical/phenotypical specificity of this subgroup of patients.Methods We retrospectively analyzed a cohort of 177 patients affected by isocitrate dehydrogenase wild-type (IDH-WT) GBM; 49 patients presented seizure at onset (SaO) and 128 were seizure free (SF). We investigated the relationship between seizures and other prognostic factors of GBMs.Results A statistically significant association between the location of the lesions in the parietal lobe and seizures was observed. The left side was more commonly affected. Interestingly, there was a statistical relationship between tumors involving the subventricular zone (SVZ) and SaO patients. The tumors were also smaller on average at diagnosis, and generalized SaOs were associated with longer overall survival.Conclusions The typical patient with IDH-WT GBM with SaO is a young (<55 year) male without a history of headache. The lesion is typically small to medium in size and located in the temporoparietal dominant lobe, with a high tendency to involve the SVZ.
Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country
Authors: Silva Ricella Maria Souza da , Collaço Polyana Maria Cruz , Cunha Karin S. , Dias Eliane Pedra 
Published: November 2021

Abstract
Objectives Colorectal cancer (CRC) is the second leading cause of cancer death in the world, with survival correlated with the extension of the disease at diagnosis. In many low-/middle-income countries, the incidence of CRC is increasing rapidly, while decreasing rates are observed in high-income countries. We evaluated the anatomopathological profile of 390 patients diagnosed with CRC who underwent surgical resection, over a six-year period, in the state of Paraíba, northeastern Brazil.
Results Adenocarcinomas accounted for 98% of the cases of primary colorectal tumors, and 53.8% occurred in female patients. The average age of the sample was 63.5 years, with 81.8% of individuals older than 50 years of age and 6.4% under 40 years of age. The most frequent location was the distal colon; pT3 status was found in 71% of patients, and pT4 status, in 14.4%. Angiolymphatic and lymph-node involvements were found in 48.7% and 46.9% of the cases respectively. Distant metastasis was observed in 9.2% of the patients. Advanced disease was diagnosed in almost half of the patients (48.1%). The women in the sample had poorly-differentiated adenocarcinomas (p = 0.043). Patients under 60 years of age had a higher rate of lymph-node metastasis (p = 0.044). Tumor budding was present in 27.2% of the cases, and it was associated with the female gender, the mucinous histological type, and the depth of invasion (pT3 and pT4).
Conclusions We conclude that the diagnosis of advanced disease in CRC is still a reality, with a high occurrence of aggressive prognostic factors, which results in a worse prognosis.
A Mobile Game Platform for Improving Social Communication in Children with Autism: A Feasibility Study
Authors: Penev Yordan , Dunlap Kaitlyn , Husic Arman , Hou Cathy , Washington Peter , Leblanc Emilie , Kline Aaron , Kent John , Ng-Thow-Hing Anthony , Liu Bennett , Harjadi Christopher , Tsou Meagan , Desai Manisha , Wall Dennis P. 
Published: November 2021

Abstract
Background Many children with autism cannot receive timely in-person diagnosis and therapy, especially in situations where access is limited by geography, socioeconomics, or global health concerns such as the current COVD-19 pandemic. Mobile solutions that work outside of traditional clinical environments can safeguard against gaps in access to quality care.
Objective The aim of the study is to examine the engagement level and therapeutic feasibility of a mobile game platform for children with autism.
Methods We designed a mobile application, GuessWhat, which, in its current form, delivers game-based therapy to children aged 3 to 12 in home settings through a smartphone. The phone, held by a caregiver on their forehead, displays one of a range of appropriate and therapeutically relevant prompts (e.g., a surprised face) that the child must recognize and mimic sufficiently to allow the caregiver to guess what is being imitated and proceed to the next prompt. Each game runs for 90 seconds to create a robust social exchange between the child and the caregiver.
Results We examined the therapeutic feasibility of GuessWhat in 72 children (75% male, average age 8 years 2 months) with autism who were asked to play the game for three 90-second sessions per day, 3 days per week, for a total of 4 weeks. The group showed significant improvements in Social Responsiveness Score-2 (SRS-2) total (3.97, p <0.001) and Vineland Adaptive Behavior Scales-II (VABS-II) socialization standard (5.27, p = 0.002) scores.
Conclusion The results support that the GuessWhat mobile game is a viable approach for efficacious treatment of autism and further support the possibility that the game can be used in natural settings to increase access to treatment when barriers to care exist.
Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
Authors: Al-Abachi Khaldoon Thanoon 
Published: November 2021

Abstract
Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed based on the Rome III criteria.
Patients and Methods A cross-sectional study was conducted at a secondary care gastrointestinal unit in Al-Salam General Hospital in Mosul city, Iraq, from November 2015 to October 2016. All patients fulfilling the Rome III criteria for IBS were screened for CD using antitissue transglutaminase IgA antibodies (anti-tTG). Patients who tested positive were subjected to endoscopic duodenal biopsy to confirm the diagnosis of CD.
Results A total of 100 patients were included in the present study (58 female and 42 male), the mean age of the participants was 40.8 years old (standard deviation [SD] ± 11.57). Ten patients (10/100, 10%) tested positive for anti-tTG antibodies. Five of the seropositive patients (5/10, 50%) showed positive biopsy results according to the Marsh classification, 3 of whom having diarrhea, and 2 with constipation.
Conclusion Positive serology and biopsy results suggestive of CD are common among patients with IBS. Screening patients with IBS for CD is justified.
The Neglected Role of Bile Duct Epithelial Cells in NASH
Authors: Cadamuro Massimiliano , Lasagni Alberto , Sarcognato Samantha , Guido Maria , Fabris Roberto , Strazzabosco Mario , Strain Alastair J. , Simioni Paolo , Villa Erica , Fabris Luca 
Published: November 2021

AbstractNonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and affects 25% of the population in Western countries. NAFLD is the hepatic manifestation of the metabolic syndrome, linked to insulin resistance, which is the common pathogenetic mechanism. In approximately 40% of NAFLD patients, steatosis is associated with necro-inflammation and fibrosis, resulting in nonalcoholic steatohepatitis (NASH), a severe condition that may progress to cirrhosis and liver cancer. Although the hepatocyte represents the main target of the disease, involvement of the bile ducts occurs in a subset of patients with NASH, and is characterized by ductular reaction and activation of the progenitor cell compartment, which incites portal fibrosis and disease progression. We aim to dissect the multiple biological effects that adipokines and metabolic alterations exert on cholangiocytes to derive novel information on the mechanisms driven by insulin resistance, which promote fibro-inflammation and carcinogenesis in NASH.