bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flächensparen in der Planung von Logistikimmobilien
Authors: Kotzold Dennis , Hüer Lucas , Griese Kai-Michael , Franz Martin 
Published: October 2021

ZusammenfassungLogistikunternehmen haben es bei der Suche nach neuen Standorten zunehmend schwerer, da geeignete Standorte immer knapper werden und ihnen wachsende Widerstände entgegenstehen: Umweltverbände und Anwohner*innen kritisieren Luftverschmutzung, Flächenverbrauch, Beeinträchtigungen des Landschaftsbilds und Zunahme des Verkehrslärms; die Lokalpolitik bevorzugt häufig Unternehmen mit höheren Gewerbesteueraufkommen und mehr (hochqualifizierten) Arbeitsplätzen. Der Druck auf die Logistikbranche, nachhaltigere Konzepte der Flächennutzung zu entwickeln und umzusetzen steigt. Zielsetzung des Artikels ist es, Ansätze aufzuzeigen, wie die Flächennutzung in der Logistik optimiert werden kann. Ein wichtiges Lösungsfeld ist auf Basis des Logistikmodells von Pfohl (2010) vor allem in den Bereichen der Flächenplanung zu verorten. Als Grundlage des Artikels wurde eine systematische Literaturrecherche durchgeführt. Die Ergebnisse zeigen Möglichkeiten auf, wie Unternehmen und Kommunen durch eine frühzeitige Planung zur Optimierung von Flächennutzung für logistische Prozesse beitragen können. Die sorgfältige Planung eines Lagers und die damit einhergehende Nutzung von effizienten Lagersystemen, verringern die benötigte Fläche und sorgen für verbesserte Prozesse im Bereich der Lager- und Umschlagslogistik. Auch lassen sich ggf. neue Lagerflächen vermeiden, wenn die bereits genutzten Flächen optimiert werden.
Reproducibility of MRI-based white matter tract estimation using multi-fiber probabilistic tractography: effect of user-defined parameters and regions
Authors: Brumer Irène , De Vita Enrico , Ashmore Jonathan , Jarosz Jozef , Borri Marco 
Published: October 2021

Abstract
Objective
There is a pressing need to assess user-dependent reproducibility of multi-fibre probabilistic tractography in order to encourage clinical implementation of these advanced and relevant approaches. The goal of this study was to evaluate both intrinsic and inter-user reproducibility of corticospinal tract estimation.

Materials and methods
Six clinical datasets including motor functional and diffusion MRI were used. Three users performed an independent tractography analysis following identical instructions. Dice indices were calculated to quantify the reproducibility of seed region, fMRI-based end region, and streamline maps.

Results
The inter-user reproducibility ranged 41–93%, 29–94%, and 50–92%, for seed regions, end regions, and streamline maps, respectively. Differences in streamline maps correlated with differences in seed and end regions. Good inter-user agreement in seed and end regions, yielded inter-user reproducibility close to the intrinsic reproducibility (92–97%) and in most cases higher than 80%.

Discussion
Uncertainties related to user-dependent decisions and the probabilistic nature of the analysis should be considered when interpreting probabilistic tractography data. The standardization of the methods used to define seed and end regions is a necessary step to improve the accuracy and robustness of multi-fiber probabilistic tractography in a clinical setting. Clinical users should choose a feasible compromise between reproducibility and analysis duration.
Increased grazing drives homogenisation but reduced grazing increases turnover in upland habitat mosaics
Authors: Pakeman Robin J. , Fielding Debbie A. 
Published: October 2021

AbstractMany ecosystems are grazed by livestock or large, wild herbivores and exist as mosaics of different vegetation communities. Changing grazing could have an impact on heterogeneity as well as on composition. A long-term, large-scale grazing experiment that maintained existing low-intensity sheep grazing, tripled it, removed it and partially substituted sheep grazing by cattle grazing was set up on a mosaic of upland vegetation types. The impact of changing grazing regimes was assessed in terms of changes in temporal and spatial species and functional beta diversity. Removal of grazing had the highest impact on species replacement, whilst increased grazing was closest to maintaining the original species complement. Wet heath and Molina mire had the lowest turnover, but wet heath showed the highest changes in unidirectional abundance as it contained species capable of increasing in abundance in response to changing grazing intensity. Agrostis-Festuca and Nardus grasslands displayed the highest level of balanced species replacement reflecting their more dynamic vegetation. In functional terms, there was no clear separation of communities based on their grazing preference, all were relatively resistant to change but Nardus grassland was the most resistant to the removal of grazing. The increased offtake associated with increased grazing led to a degree of homogenisation as grazing tolerant species associated with preferred communities increased in the unpreferred ones. Decisions about grazing management of the uplands involve many trade-offs, and this study identified potential trade-offs between stability and homogenisation to add to existing ones on the biodiversity of different groups of species and on ecosystem services.
Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement
Authors: Stricagnoli M. , Sciaccaluga C. , Mandoli G. E. , Rizzo L. , Sisti N. , Aboumarie H. S. , Benfari G. , Maritan L. , Tsioulpas C. , Bernazzali S. , Maccherini M. , Natali B. M. , Focardi M. , D’Ascenzi F. , Lisi M. , Valente S. , Mondillo S. , Cameli M. 
Published: October 2021

AbstractRight ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor.
Contemporary Judeo–Spanish Poetry for Young Readers
Authors: August-Zarębska Agnieszka 
Published: October 2021

AbstractThis article presents contemporary Judeo-Spanish poetry for children in the context of the postvernacular mode (when the language is not used any more in everyday communication) of the language. It discusses the poetry collections of three authors who have published Judeo-Spanish poems in the twenty-first century: Ada Gattegno-Saltiel, Avner Perez, and Sarah Aroeste, as well as the project Yeladino, which is an anthology of Judeo-Spanish translations of Hebrew poems. It analyses the books and projects in terms of their subject matter, language, and poetic devices, as well as the relation of some of them with music, theatre-music performance, and educational activities. The paper raises the question of audience of this poetry, allowing for the fact that nowadays there are no children learning Judeo-Spanish as their first language, and that the language itself is considered severely endangered. The paper states the presence of the dual address in these books, i.e. to children and adults, both on the level of implied and real audience.
Concurrent and Prospective Associations Between Social Anxiety and Responses to Stress in Adolescence
Authors: Blöte Anke W. , Miers Anne C. , Westenberg P. Michiel 
Published: October 2021

AbstractSeveral studies have investigated the relationship between adolescents’ responses to stress and general anxiety and depression, but only few studies addressed the relationship between responses to stress and social anxiety. The current three-wave longitudinal study, that covered a period of 5 years with a time interval of on average two years between waves, examined concurrent as well as prospective relations between adolescents’ self-reported stress responses, including coping responses, and self-perceived social anxiety. Both the predictive power of social anxiety for different stress responses and, reversely, of stress responses for social anxiety were evaluated. Participants were 331 youth (170 boys) aged 9 to 17 years old at Wave 1. Self-report questionnaires were used to measure social anxiety, responses to social stress, and depressive symptoms. Results showed significant concurrent relations between social anxiety and maladaptive stress responses. Moreover, the study yielded evidence for social anxiety predicting stress responses across time as well as stress responses predicting social anxiety, although evidence for the former link is stronger. The findings suggest that a relative lack of adaptive stress responses may heighten social anxiety and social anxiety in turn may trigger maladaptive as well as adaptive responses to social problems. The relevance of these findings for social anxiety prevention and intervention purposes are discussed.
“To Normalize is to Impose a Requirement on an Existence.” Why Health Professionals Should Think Twice Before Using the Term “Normal” With Patients
Authors: Rost Michael 
Published: October 2021

AbstractThe term “normal” is culturally ubiquitous and conceptually vague. Interestingly, it appears to be a descriptive-normative-hybrid which, unnoticedly, bridges the gap between the descriptive and the normative. People’s beliefs about normality are descriptive and prescriptive and depend on both an average and an ideal. Besides, the term has generally garnered popularity in medicine. However, if medicine heavily relies on the normal, then it should point out how it relates to the concept of health or to statistics, and what, after all, normal means. Most importantly, the normativity of the normal needs to be addressed. Since the apparently neutral label “normal” can exclude, stigmatize, and marginalize people who are defined in contrast to it as abnormal, health professionals should think twice before using the term with patients. The present critical perspective advocates against using the term “normal,” as long as no understanding of a person’s individual normality has been attained. It advocates for the right to autonomously determine one’s own normality. For health professionals I do not see worthwhile benefits of subscribing to the concept of (non-individual and normatively loaded) “normality” and imposing it on their patients. But I do see many risks.
ASCO 2021—selection of personal highlights in early stage non-small cell lung cancer
Authors: Absenger Gudrun , Pircher Andreas 
Published: October 2021

SummaryThis article intends to summarize personal non-small cell lung cancer (NSCLC) highlights of the virtual ASCO 2021 meeting. Immunotherapy is now a mainstay of advanced stage NSCLC treatment and there are several ongoing studies investigating the role of immunotherapy in early stage NSCLC. At ASCO 2021 the first data on atezolizumab in the adjuvant setting were presented and give a positive signal that immunotherapy will also become an option for patient in early stage NSCLC. Furthermore, overall survival (OS) updates of two studies investigating the effects of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in the adjuvant setting of EGFR-mutated NSCLC patients were presented. In conclusion ASCO 2021 provided the lung cancer community with inspiring new data especial in early stages and challenges the community with integration of these data into our daily clinical routine.
Gemäßigt konstruktivistische Prozessmerkmale fächerübergreifenden Unterrichts im Fächerverbund Sport und Biologie
Authors: Kramer Niklas , Wegner Claas 
Published: October 2021

ZusammenfassungSportunterricht wird in vielen konzeptionell-reflektorischen Arbeiten als ein ergiebiger Partner für fächerübergreifende Unterrichtsmaßnahmen gesehen. Ein solch mehrperspektivisch orientierter Sportunterricht bietet im Hinblick auf den sportpädagogischen Diskurs eine Möglichkeit, kognitive Aktivität im Schulsport zu implementieren und die Relevanz des Faches zu erhöhen. Dennoch zeigt sich ein Evaluationsdefizit eines solchen Unterrichts. Die vorliegende Studie wirkt diesem Defizit entgegen und setzt sich zunächst mit strukturellen Merkmalen eines fächerübergreifenden Unterrichts auseinander. Da sowohl das Konstrukt der kognitiven Aktivierung als auch der fächerübergreifende Unterricht eine Nähe zum Konstruktivismus offenbaren, soll in der vorliegenden Studie untersucht werden, inwiefern sich ein fächerübergreifender Unterricht in den konstruktivistischen Prozessmerkmalen (situativ, aktiv, konstruktiv) vom Fachunterricht unterscheidet. Dafür nahmen insgesamtN = 75 Schüler*innen (15,2 Jahre) aus vier Kursen des Sekundarbereichs an einer fächerübergreifenden Unterrichtseinheit im Fächerverbund Sport und Biologie teil. Zur Evaluation der konstruktivistischen Prozessmerkmale wurde der Kurzfragebogen nach Basten et al. eingesetzt, der für den fächerübergreifenden Unterricht sowie für den Sport- und Biologieunterricht bewertet wurde. Messwiederholte Varianzanalysen zeigten signifikante Unterschiede zwischen den fächerübergreifenden Unterrichtseinheiten und dem Biologieunterricht in allen drei Subskalen. Der Sportunterricht unterschied sich lediglich in der Subskala „situativ“ von den Unterrichtseinheiten. Der Einfluss des subjektiven Vorwissens auf die Bewertung der fächerübergreifenden Unterrichtseinheiten konnte nur für die Subskala „konstruktiv“ festgestellt werden. Schüler*innen mit viel Vorwissen bewerteten diese im fächerübergreifenden Zusammenhang signifikant höher. Die Studie stützt damit die bereits theoretisch angenommene höhere Ausprägung der prozessbezogenen Merkmale des gemäßigten Konstruktivismus in fächerübergreifenden Unterrichtseinheiten im Vergleich zum Biologieunterricht. Zudem wird die Sonderstellung des Faches Sport deutlich, die in weiteren Studien untersucht werden sollte.
Urban Stormwater Modeling with Local Inertial Approximation Form of Shallow Water Equations: A Comparative Study
Authors: Wang Weiqi , Chen Wenjie , Huang Guoru 
Published: October 2021

AbstractThis study focused on the performance and limitations of the local inertial approximation form model (LIM) of the shallow water equations (SWEs) when applied in urban flood modeling. A numerical scheme of the LIM equations was created using finite volume method with a first-order spatiotemporal Roe Riemann solver. A simplified urban stormwater model (SUSM) considering surface and underground dual drainage system was constructed based on LIM and the US Environmental Protection Agency Storm Water Management Model. Moreover, a complete urban stormwater model (USM) based on the SWEs with the same solution algorithm was used as the evaluation benchmark. Numerical results of the SUSM and USM in a highly urbanized area under four rainfall return periods were analyzed and compared. The results reveal that the performance of the SUSM is highly consistent with that of the USM but with an improvement in computational efficiency of approximately 140%. In terms of the accuracy of the model, the SUSM slightly underestimates the water depth and velocity and is less accurate when dealing with supercritical flow in urban stormwater flood modeling. Overall, the SUSM can produce comparable results to USM with higher computational efficiency, which provides a simplified and alternative method for urban flood modeling.
Association of ATG5 gene polymorphism with Parkinson’s disease in a Han Chinese population
Authors: Han Jing , Feng Ganghua , Wu Jibao , Zhang Yi , Long Zhipeng , Yao Xiaoxi 
Published: October 2021

Abstract
Purpose
There is growing evidence that autophagy-related gene 5 (ATG5) is involved in neural development, neuronal differentiation, and neurodegenerative diseases. The purpose of this study was to investigate the association between ATG5 gene single-nucleotide polymorphisms (SNPs) and Parkinson’s disease (PD) in the Han population.

Methods
A case–control study was conducted in 120 PD patients and 100 healthy volunteers. MassArray platform was used to analyze polymorphisms in three different regions of ATG5 gene (rs510432, rs573775 and rs17587319). In the included subjects, 50 PD patients and 50 healthy volunteers were selected, and the plasma ATG5 concentration was detected by enzyme-linked immunosorbent assay (ELISA). The allele and genotype frequencies of SNPs were assessed using the SHEsis program.

Results
We found a significant correlation between rs17587319 and PD, and the subcomponent showed a high correlation between rs17587319 with cognitive impairment and age at onset in PD patients. At the same time, the total plasma ATG5 level of PD patients and the plasma ATG5 expression level of early-onset Parkinson’s disease (EOPD) patients were significantly higher than the control group, while there was no significant difference of ATG5 expression between late-onset Parkinson’s disease (LOPD) patients and the control group.

Conclusion
These findings suggest that genetic variations in the ATG5 gene and low levels of the ATG5 protein are associated with susceptibility to PD and with cognitive impairment in PD patients. ATG5 could be a potential biomarker to assess the severity and prognosis of PD.
Role of Transcranial Doppler in Cardiac Surgery Patients
Authors: Gupta Pranav , Steiner Luzius A. 
Published: October 2021

AbstractPurpose of ReviewThis review discusses applications of transcranial Doppler (TCD) in cardiac surgery, its efficacy in preventing adverse events such as postoperative cognitive decline and stroke, and its impact on clinical outcomes in these patients.Recent FindingsTCD alone and in combination with other neuromonitoring modalities has attracted attention as a potential monitoring tool in cardiac surgery patients. TCD allows not only the detection of microemboli and measurement of cerebral blood flow velocity in cerebral arteries but also the assessment of cerebral autoregulation.SummaryNeuromonitoring is critically important in cardiac surgery as surgical and anesthetic interventions as well as several other factors may increase the risk of cerebral embolization (gaseous and particulate) and cerebral perfusion anomalies, which may lead to adverse neurological events. As an experimental tool, TCD has revealed a possible association of poor neurological outcome with intraoperative cerebral emboli and impaired cerebral perfusion. However, to date, there is no evidence that routine use of transcranial Doppler can improve neurological outcome after cardiac surgery.
Different glomerular filtration rate estimating formula for prescribing DOACs in oldest patients: appropriate dosage and bleeding risk. Post hoc analysis of a prospective cohort
Authors: Calsolaro Valeria , Okoye Chukwuma , Rogani Sara , Calabrese Alessia Maria , Dell’Agnello Umberto , Antognoli Rachele , Guarino Daniela , Monzani Fabio 
Published: October 2021

Abstract
Background
Direct oral anticoagulants (DOACs) pharmacokinetics depends on estimated glomerular filtration rate (eGFR), whose estimation is crucial for optimal risk/benefit balance.

Aims
To assess the concordance among different eGFR formulas and the potential impact on DOACs prescription appropriateness and bleeding risk in oldest hospitalized patients.

Methods
Post hoc analysis of a single-centre prospective cohort study. eGFR was calculated by creatinine-based (MDRD, CKD-EPICr, BIS1) and creatinine–cystatin-C-based (CKD-EPIComb and BIS2) formulas. Patients were stratified according to eGFR [severely depressed (SD) 15–29; moderately depressed (MD) 30–49; preserved/mildly depressed (PMD): ≥ 50 ml/min/1.73 m2]. Concordance between the different equations was assessed by Cohen’s kappa coefficient.

Results
Among AF patients, 841 (59.2% women, mean age 85.9 ± 6.5 years) received DOACs. By CKD-EPICr equation, 135 patients were allocated in the SD, 255 in the MD and 451 in the PMD group. The concordance was excellent only between BIS 2 and CKD-EPIComb and MDRD and CKD-EPICr, while was worse (from good to poor) between the other formulas. Indeed, by adding cystatin-C almost over 1/3 of the patients were reallocated to a worse eGFR class. Bleeding prevalence increased by 2–3% in patients with discordant eGFR between formulas, reallocated to a worse chronic kidney disease (CKD) stage, although without reaching statistical significance. CKD-EPIComb resulted the best predictor of bleeding events (AUROC 0.71, p = 0.03).

Discussion
This study highlights the variability in CKD staging according to different eGFR formulas, potentially determining inappropriate DOACs dosing. Although the cystatin-C derived CKDEPIComb equation is the most accurate for stratifying patients, BIS1 may represent a reliable alternative.
„Heroismus als Weg zur Transzendenz“. Metadiskursive Religionsbezüge und apokalyptische Diskurspraxis der Neuen Rechten
Authors: Schilk Felix 
Published: October 2021

ZusammenfassungIn der Rechtsextremismusforschung wird die Instrumentalisierung von Religionen zu Zwecken politischer Agitation ausführlich untersucht. Der Beitrag differenziert diese Perspektive, indem er nach der Form und Funktion religiöser Deutungsmuster in rechten Krisennarrativen fragt.In einem theoretischen Teil werden in einer wissenssoziologischen Perspektive zunächst strukturelle Gemeinsamkeiten von Konservatismus, Rechtspopulismus und der Neuen Rechten sowie Ähnlichkeiten von rechten Krisennarrativen und apokalyptischen Texten hervorgehoben. In zwei empirischen Analyseschritten werden dann (I) anhand von Quellen aus dem Umfeld der Neuen Rechten zwei metadiskursive Bezüge auf Religionskonzepte systematisiert und (II) durch die exemplarische Analyse populärer rechter Narrative die Struktur und Funktion von apokalyptischen Deutungsmustern skizziert.Esoterische Religionsbezüge rekurrieren auf die traditionalistische Philosophie und betonen den immanenten Gehalt einerphilosophia perennis. Im Rahmen exoterischer Religionsbezüge werden vor allem die sozialintegrativen Aspekte der Religion als Institution hervorgehoben. In metapolitischen Krisennarrativen werden beide Bezüge in Form von apokalyptischen Deutungsmustern aufbereitet, wobei der Figur desKatechoneine wichtige Rolle zukommt. Dabei wird deutlich, dass die Neue Rechte apokalyptische Deutungsmuster tradiert, weil sie zur Legitimation und Durchsetzung ihrer politischen Hegemonieambitionen auf permanente Krisennarrationen angewiesen ist.Die wissenssoziologische Perspektive macht eine ambivalente Struktur neurechter Texte sichtbar und kann Anschluss- und Transformationsmöglichkeiten von rechten Narrativen und Diskursen erklären. Der Beitrag basiert auf einer diskursanalytischen Untersuchung neurechter Publikationen.