bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular profiling of congenital glioblastoma using a next-generation sequencing panel
Authors: Corrêa Débora Cabral de Carvalho , Tesser-Gamba Francine , Silva Nasjla Saba da , Capellano Andrea Maria , Alves Maria Teresa de Seixas , Dastoli Patrícia Alessandra , Costa Marcos Devanir Silva da , Cavalheiro Sergio , Toledo Silvia Regina Caminada de 
Published: May 2021

Background Congenital glioblastoma (cGBM), presenting
prenatally or within the first months of life, is among the rarest type
of congenital brain tumor, with approximately 120 cases reported. Due to
its infrequent occurrence, few studies have focused on the molecular and
genetic aspects of this tumor, and the mutational events involved in the
pathogenesis and progression of cGBM still remain poorly understood.
This study aimed to investigate molecular alterations, with a potential
prognostic marker and therapeutic target in cGBM using the
next-generation sequencing (NGS) strategy. Methods We selected
seven tumor samples from patients diagnosed with cGBM and treated at
Pediatric Oncology Institute-GRAACC/UNIFESP. NGS was performed to
identify somatic genetic variants in tumor samples using the Oncomine
Childhood Cancer Research Assay panel, from
ThermoFisher Scientific, designed specifically for
pediatric neoplasms. Results Of all seven patients analyzed,
three patients exhibited tumors with genetic variants, which include two
pathogenic variants in NF1 and SUZ12 genes that have not
been reported in cGBM yet, an increase in the number of copies
of ALK gene, and two gene fusions, PPP1CB-ALK
and TPM3-NTRK1. Also, none of the cases showed variants
in H3F3A, TP53 and ATRX genes, alterations which
are frequently seen in pediatric and adolescent
GBM. Conclusions Our results suggest that cGBM may comprise a
unique tumor entity and alterations in ALK and NTRK genes
provide a potential target for therapy. Therefore, identification of
genetic variants in cGBM is highly relevant in order to define prognosis
and therapeutic strategies.
Changes in the methodology of teaching foreign languages at higher educational institutions under current conditions
Authors: Chahrak Nataliya , Кosharna Natalia , Nazarenko Olena , Terletska Liubov , Vovchasta Nataliia 
Published: May 2021

In 2020, the majority of higher educational institutions have faced global and unique problems that are particularly acute at the social, economic, scientific and educational level. The purpose of the academic paper is to consider the adoption and transformation of the methodology of teaching foreign languages at the HEIs and analyze how much has the interaction of students changed and how the capitalization of knowledge is carried out in the implementation of virtual and online education. The academic paper describes how new teaching methods are introduced and implemented in quarantine conditions in the university education system. The basic methods of the investigation are as follows: the method of experiment, questionnaire and observation; the interdisciplinary nature of the research is also marked by the use of a combination of analytical methods. The hypothesis lies in the fact that the conditions of virtual distance education involve changes in the complex of methods and their technological adaptation. The scientific article contains the answers, challenges and practices used in the process of teaching foreign languages in the space of university education.
Observations sur l’usage linguistique des poilus pendant la Grande Guerre et sa mise en scène rétrospective dans les bandes dessinées
Authors: Große Sybille , Sowada Lena 
Published: May 2021

Abstract
Dans cette contribution, nous étudions l’expression linguistique artistique dans une sélection de trois bandes dessinées sur la Première Guerre mondiale qui furent publiées environ cent ans après la fin de la guerre. Pour ce faire, nous confronterons ce langage stylisé à l’usage linguistique authentique de poilus tel qu’il apparaît dans leur correspondance privée et dans les carnets de guerre. Sous l’angle du lexique, les textes authentiques et les textes artistiques se caractérisent par une même affinité avec le français populaire et familier et, dans une moindre mesure, avec l’argot des tranchées. L’oralité mise en scène dans les BD et caractérisée comme oralité simulée se distingue en revanche par un emploi plus ludique de la langue et par un nombre plus élevé de vulgarismes par rapport aux documents authentiques. De plus, le caractère fictif et stylisé des BD contribue à une variation plus prononcée de lexèmes argotiques, populaires et familiers, notamment dans la désignation de l’ennemi allemand, que nous ne trouvons pas chez les scripteurs soldats contemporains de la Première Guerre mondiale.
البطالة وأثرها على معدلات الجريمة - في إقليم كوردستان العراق
Authors: Mohammed Dilgash Ahmed 
Published: May 2021

تتعرض هذه الدراسة لبيان العلاقة بين معدلات الجريمة وارتباطها بمعدلات البطالة في إقليم كوردستان العراق ، ومن المعروف جغرافيا أن إقليم كوردستان يقع بيئة إقليمية غير مستقرة أمنيا، وتجدر الإشارة هنا أن معدلات البطالة قد ترتفع في الدول النامية أكثر من معدلات ارتفاعها في الدول المتقدمة ، نظرا لما تعانيه تلك الدول النامية من مشاكل اقتصادية واجتماعية كبيرة .
ومن المعروف أن البطالة قد تؤدي إلى الاختلال النفسي لدى الفرد مما ينعكس ذلك سلبا على المجتمع فيحدث فيه الاختلال الاجتماعي وعدم التوازن بين أفراده ، مما قد يدفع إلى ارتكاب العديد من الجرائم ، ومن أخطر تلك الجرائم مشكلة الإدمان التي قد تؤدي الى العديد من الجرائم الأخرى ، حيث يعد الإدمان أحد أخطر الجرائم التي تهدد الأمن والاستقرار لدى الأفراد والمجتمعات .
ولقد ظلت البطالة هاجسا مرعبا يقف أمام الشعوب والحكومات دون التوصل إلى حل جذري له، لاسيما بعدما أصبحت العولمة إطارا يؤثر في العالم أجمع، فأي انهيار أو صعود لأسهم شركة كبرى أو سلعة رئيسة مثل البترول، أو تغير نظام حاكم في دولة كبرى كل ذلك أو جزء منه أصبح كفيلا بتوفير فرص عمل جديدة أو القضاء على وظائف كانت قائمة وتصدير عدد ليس بالقليل من العاملين إلى أعداد البطالة .
Clinically Amyopathic Dermatomyositis Associated with Recurrence of Esophageal Cancer: A Case Report
Authors: Eversman Anna , Ahsanuddin Sayeeda , Saltzman Joel , Silverman Paula , Beveridge Mara 
Published: May 2021

Background: Approximately 20% of patients displaying skin changes characteristic of dermatomyositis do not develop clinical or enzymatic evidence of muscle inflammation within 6 months of onset, leading to a diagnosis of clinically amyopathic dermatomyositis (CADM). While the association between dermatomyositis and malignancy is well-documented, the clinical significance of CADM is still being elucidated.
Case Presentation: We report a case of new-onset CADM associated with recurrent esophageal adenocarcinoma for clinical interest and to add to the limited literature on CADM.
Conclusion: To date, there is only one report of concurrent CADM and esophageal cancer. We present this case for clinical interest and to add to the limited literature on CADM.
Differentiation of vascular claudication due to bilateral common iliac artery stenosis versus neurogenic claudication with spinal stenosis
Authors: Shields Lisa B. E. , Iyer Vasudeva G. , Self Stephen B. , Zhang Yi Ping , Shields Christopher B. 
Published: May 2021

Background:
Differentiating between neurogenic and vascular claudication may be difficult. Vascular claudication due to aortic and iliac artery occlusions may present as low back, hip, and buttock pain while walking short distances. These findings are often very similar to those seen for neurogenic claudication attributed to lumbar stenosis.

Case Description:
A 68-year-old female presented with low back, right hip, and groin pain while walking short distances. She had previously undergone lumbar and cardiac surgery. Now, with negative repeated lumbar studies, the CT angiogram (CTA) revealed a dense calcified plaque in the right common iliac artery resulting in 90% stenosis at its origin and <50% stenosis of the left common iliac artery. Once bilateral common iliac artery kissing stents were placed, the patient’s symptoms resolved.

Conclusion:
Spine surgeons should be aware that vascular and neurogenic claudication may mimic each other. Obtaining MR studies of the lumbar spine and EMG/NCV, along with the appropriate vascular studies (CTAs), help differentiate between the two, and result in the appropriate operative choices.
Bioethanol Production from Tapioca-Waste as Potential Additive Fuel for LCGC (Low-Cost Green Car)
Authors: Prastiwi Danty Oktiana , Anggita Novia , Arishandy Yudha Putra 
Published: May 2021

The majority style of people in transportation is 24% contribute to increasing premium demand as energy. Unfortunately, fossil fuel is not renewable and limited quantity. Its means, potential biomass of tapioca waste should be an alternative energy source to solve that problem. Today, the biosystem of bioethanol production needs to be optimized to maximize filtration and minimize the production cost. First, composition and time incubation needs to be optimized. The research found that to fermented 50 g waste on 200 mL water, we need 2 g of yeast, and the time of harvesting optimum is fourth days with 17% ethanol. Without acid hydrolyze, tapioca waste in yeast fermentation serves 2600 ppm glucose on the first day and increases significantly on the second day with 2964.77 ppm glucose. This concentration found by DNS (Dinitrosalicylic acid) method. Yeast is the subject that converts glucose on medium to be ethanol. Secondly, that medium distillate gets pure ethanol. Thirdly, this ethanol mix with premium in some concentration, include 0%, 10%, 20%, 30%, 40%, 50%. This variant would do test emission to understand the advantages of tapioca bioethanol compare to fossil fuel. The result of this research should be support government to enhance LCGC (Low-cost green car) program to achieve lower air pollutants, green energy resolution, and cleaner production in tapioca industry.

Key Word: bioethanol, emission, formulation, LCGC, tapioca,
Brexit в контексте основных британских ценностей (по материалам качественных СМИ)
Authors:   МГУ имени М.В. Ломоносова, факультет журналистики, Кумылганова Ирма Александровна , Куцепалова Надежда Константиновна ,   МГУ имени М.В. Ломоносова, факультет журналистики
Published: May 2021

Статья посвящена двум параллельным процессам, проходящим в Великобритании в последние годы, – выходу страны из состава Европейского союза и формированию официальной версии «основных британских ценностей». Цель работы – определить, какая взаимосвязь существует между развитием этих тем в качественных изданиях. Результаты исследования показали, что, несмотря на одинаково негативное отношение к Brexit, издания по-разному оценили влияние проблемы национальных ценностей на результаты референдума.
«Черная книжка» Зинаиды Гиппиус и «Черная тетрадь» Нины Берберовой (заметки на полях)
Authors:   независимый исследователь, Закрыжевская Елена Андреевна 
Published: May 2021

В статье рассматривается связь главы книги мемуаров «Курсив мой» писательницы первой волны эмиграции Нины Берберовой и «Петербургского дневника» одной из выдающихся фигур Серебряного века Зинаиды. Гиппиус. Анализируется исторический контекст, самопрезентация З.Н. Гиппиус и Н.Н. Берберовой.
Отражение «марсельской чумы» во французской прессе (по материалам La Gazette и Le Journal des Sçavans, 1720–1723 гг.)
Authors:   МГУ имени М.В. Ломоносова, факультет журналистики, Гуляева Инна Борисовна 
Published: May 2021

Проблема освещения в СМИ эпидемий болезней приобрела особую актуальность в 2020–2021 гг. В статье этот вопрос рассмотрен в историческом аспекте, проанализирован подход первых периодических изданий Франции к отражению эпидемии чумы в Марселе в 1720–1721 гг. Особенности этого отражения связаны как с отношениями между СМИ и обществом в XVIII в., так и со спецификой изданий La Gazette и Le Journal des sçavans.
THE OPERATION OF POWER IN PANIC BUYING DURING CORONA OUTBREAK
Authors: Tedjaatmadja Herwinda Maria 
Published: May 2021

<p align="center"><strong>ABSTRACT</strong></p><p><strong><em> </em></strong></p><p> Coronavirus disease (Covid-19) has become a trending topic nowadays because it has affected the life of many people all around the world. One of the events during Corona outbreak is panic buying. During the pandemic, it is revealed that power is omnipresent which means that it operates everywhere in many forms. To analyze how power operates, the writer uses the theory of power by Foucault (1980) since a number of his writing are applicable as it connects not only power and knowledge but also power and truth. In his book, Foucault (1980) denoted that knowledge is power and when there is power, there is resistance and they are all connected. In order to analyse how power operates, qualitative research methodology was conducted to find the meaning behind it so that the research finding will be more related to real life. The whole series of panic buying begins with the lack of knowledge about Covid-19. When people realize that Covid-19 is not just an ordinary flu and think that the government did not take this seriously, they started not to believe what the government had said and it led to resistance.The results show that power does operate in panic buying during the corona outbreak although nowadays, there have been some changes regarding the Covid-19.</p><p> </p>
ХУДОЖНЬО-ОБРАЗНЕ ТА ЗМІСТОВНЕ ВТІЛЕННЯ НАРОДНИХ ТРАДИЦІЙ В УКРАЇНСЬКОМУ ТЕАТРІ ПОЧАТКУ XX СТОЛІТТЯ (ЗА МАТЕРІАЛАМИ ЖУРНАЛУ "НОВЕ МИСТЕЦТВО")
Authors: Рибченко О. Г. 
Published: May 2021

The purpose to demonstrate the implementation of folk traditions in the 1920s scenography on the example of two theatrical performances: “Sava Chaly” (Theatre “Berezil,” Kharkiv, 1927) and “The Fair at Sorochyntsi” (State Ukrainian Opera, Kyiv, 1925) based on the materials of the archival editions of the “New Art” journal (Kharkiv, 1925–1928). Methodology. The methodological basis of the study is a systematic approach, methods of synthesis, generalization, comparative historical and art history analysis. Results. The review of the archival issues of the weekly “New Art” journal allowed to confirm that folk traditions played a prominent role in theatre art at the beginning of the XX century and served as a source of inspiration for scenographers, composers, performers etc. The study indicates the importance of the “New Art” journal as a primary source of information on the cultural events in Ukraine. Based on its issues, the study analyses the publications and photo materials on the scenography of the “Sava Chaly” (Theatre “Berezil,” Kharkiv, 1927) and “The Fair at Sorochyntsi” (State Ukrainian Opera, Kyiv, 1925) performances. The elements of Ukrainian folk art in these performances were emphasised. It is noted that evocation of the folk traditions in the scenography was both a showcase and a guarantee of the preservation of the ethnocultural phenomena in the theatrical environment of the period. The novelty of the study is the identification of the specifics of the use of folk traditions and ethnic elements in the scenography of the 1920s, as well as the introduction into the scientific discourse of the “New Art” journal's issues, which offer materials on the implementation of the folk traditions by directors, stage designers and performers. The practical significance. The study can be useful for research of the history of Ukrainian scenography; the analysis of the artistic heritage of stage designers of the XX century's leading theatres is vital for enriching the modern Ukrainian stage design.
ОСОБЛИВОСТІ ДИЗАЙНУ ОФІСНИХ ПРИМІЩЕНЬ ДЛЯ ЛЮДЕЙ З ПОРУШЕННЯМИ ОПОРНО-РУХОВОГО АПАРАТУ
Authors: Полякова О. В. , Булгакова Т. В. , Косенко Д. Ю. , Шмельова О. Є. , Марета О. Є. 
Published: May 2021

Purpose. The aim of the work is to identify the design features of office premises for people with musculoskeletal disorders and to determine the main functional groups of the subject content of the environment with universal equipment. Methodology. The study is based on a systemic and environmental approach, which allows considering the interior space of office premises and specialized equipment for people with musculoskeletal disorders as a hierarchically subordinate entity. The source base of the research were scientific and journalistic articles, domestic and foreign project developments of office spaces, catalogs of office furniture and equipment. Results. We analyzed the research base on the problems of organizing an office environment for people with disabilities and disorders of the musculoskeletal system. Based on a systematic approach, we analyzed modern office spaces for the possibility of applying the principles of universal design when creating the design of a modern working environment, which will provide equal working opportunities for people with chronic disabilities and will ensure the prevention of diseases of the musculoskeletal system of workers. We have developed a structural model of universal interior office space in order to further expand and refine it, anticipate the development of technologies, equipment and design solutions, improve the working conditions of all employees. We analyzed the main functional groups of office filling with furniture and equipment in terms of their ability to facilitate the use of people with musculoskeletal disorders, as well as the prevention of such diseases in other workers. The right combination of universal and special equipment for all functional groups of the office environment will create a space that is comfortable for the work of different people, it will ensure the maintenance of health and the prevention of diseases associated with static loads of a sedentary way of working. Scientific novelty. We formed the design model structure for the interior environment of office premises for people with disabilities of the musculoskeletal system. Practical significance of the study is determined by the expansion and deepening of knowledge about the formation of the design of office environments and filling them with equipment that provides the possibility of comfortable work for people with musculoskeletal disorders and can be used in the practice of designing appropriate environments.
Pemodelan Gerak Partikel Butiran pada Proses Granulasi pada Pembuatan Pupuk Granul
Authors: Mardiansyah Yopy , Meldra Delia , Yulia Yulia 
Published: May 2021

Penggunaan pupuk untuk menjaga kesuburan tanah saat ini masih menjadi pilihan utama bagi petani di Indonesia. Tujuan penggunaan pupuk ini adalah untuk menjaga kesuburan tanah. Pupuk yang banyak digunakan adalah jenis pupuk anorganik. Hal ini terlihat dari permintaan pupuk anorganik yang terus meningkat tiap tahunnya. Padahal penggunaan pupuk jenis anorganik dengan takaran yang tidak jelas dan secara terus menerus akan menimbulkan efek sebaliknya yaitu menurunkan kualitas tanah dalam penyerapan unsur hara. Salah satu upaya yang dapat ditempuh dalam mengembalikan kemampuan tanah dalam menyerap unsur hara adalah dengan mengganti pupuk anorganik dengan pupuk organik. Pupuk organik dapat mengembalikan kandungan organik di dalam tanah. pemberian pupuk organik dalam bentuk granul dapat meningkatkan pertumbuhan dan produksi tanaman. Pada proses granulasi, adonan pupuk mengalami pembesaran karena partikel-partikel halus saling menempel membentuk butiran yang lebih besar. Pupuk yang saling melekat mengalami perputaran akibat gerakan dari piringan tempat adonan. Perlu dilakukan pengadukan agar butiran yang dihasilkan tidak melebihi ukuran yang diinginkan. Jika waktu pengadukan tidak tepat, maka akan terjadi penggumpalan pada bagian bawah dan dinding-dinding piringan. Oleh sebab itu, perlu diketahui model gerak butiran pupuk pada proses granulasi untuk mengetahui waktu pengadukan yang tepat.
Optimasi Pergerakan Motor Stepper 3 Axis Dengan Metode Microstepping Dan Pembuatan Unique Code Pada Lead Frame
Authors: Suhendra Alfino , Prebianto Nanta Fakih , Asaad Nur Sakinah 
Published: May 2021

Perkembangan teknologi industri saat ini memang tidak bisa diragukan lagi semenjak munculnya industri 4.0 yang sangat menunjang produktifitas dan efektifitas. Hal ini semakin menuntut setiap perusahaan untuk lebih berkembang dan dapat bersaing dalam dunia industry. Oleh karena itu, dibutuhkan sistem yang dapat mengurangi pemakaian tenaga manusia tetapi tetap meningkatkan jumlah produktifitas. Microstepping merupakan sebuah mekanisme pada industri yang menggunakan fungsi dasar pada motor stepper yaitu pergerakan, dengan mengurangi probabilitas yang mungkin dapat menyebabkan timbulnya permasalahan pada sistem itu sendiri. Sistem ini diterapkan pada alat yang sebelumnya sudah dibuat bernama “Chip RFID Tester” yang berfungsi untuk melakukan pergerakan dalam pembacaan chip RFID yang tertera pada lead frame. Untuk peningkatan efisiensi yang mampu dilakukan oleh Chip RFID Tester dengan menggunakan metode microstepping mencapai ±50% dibandingkan dengan tidak menggunakan microstepping.
PENGARUH LINGKUNGAN KERJA DAN BUDAYA ORGANISASI TERHADAP REPUTASI PERUSAHAAN DENGAN KOMITMEN ORGANISASI SEBAGAI VARIABEL INTERVENING
Authors: Nashar Muhammad , Taru Taru 
Published: May 2021

Tujuan utama dari penelitian ini adalah untuk menguji dan menganalisis pengaruh lingkungan kerja dan beban kerja terhadap reputasi perusahaan dengan komitmen organisasi sebagai variabel intervening di PT. Petra Garda Paramita dengan menggunakan pendekatan deskriptif kuantitatif. Data dalam penelitian diperoleh dari 100 responden karyawan PT. Petra Garda Paramita. Analisis data dalam penelitian ini menggunakan metode alternatif dari structural equation modeling (SEM) yaitu partial least square (PLS). Tahap pertama dalam penelitian ini untuk menguji validitas pertanyaan setiap variabel berikut dengan reliabilitasnya. Tahap kedua menguji hubungan antara lingkungan kerja dan beban kerja terhadap reputasi perusahaan dengan komitmen organisasi sebagai variabel intervening. Hasil dari penelitian ini menyatakan bahwa variabel lingkungan kerja dan beban kerja berpengaruh positif namun tidak signifikan terhadap reputasi perusahaan, sementara komitmen organisasi memberikan pengaruh mediasi penuh terhadap hubungan lingkungan kerja dan beban kerja terhadap reputasi perusahaan dengan ditemukannya pengaruh positif dan signifikan.
ANALISIS PROMOSI PENJUALAN GOPAY DENGAN MENGGUNAKAN SOCIAL NETWORK ANALYSIS DI MEDIA SOSIAL TWITTER
Authors: Srinanda Dewinta , Sisilia Kristina , Perangingangin Yahya 
Published: May 2021

Terdapat peningkatan yang signifikan dalam volume transaksi elektronik di 2018, Gopay adalah penyedia E-Wallet dengan pengguna yang paling aktif dan promosi adalah strategi pemasaran yang paling aktif dari Gopay. Saat ini banyak orang memposting pengalaman mereka di media sosial dan ada cara untuk mengakses data tersrbut, yaitu dengan menggunakan API (Application program interface). Tujuan dari studi ini adalah untuk mengetahui tentang promosi penjualan Gopay di Twitter dan analisis jaringan sosial Gopay dalam bentuk pemeran kunci dalam menyebarkan informasi tentang promosi penjualan. Penelitian ini menggunakan metode kuantitatif dengan jenis penelitian deskriptif dan metode kuota sampling, karena pengambilan data dibatasi menggunakan perangkat lunak RSstudio. Analisis Jaringan Sosial digunakan untuk teknik analisis data yang akan memvisualisasikan jaringan dengan bantuan perangkat lunak Gephi serta menentukan pmeeran kunci. Berdasarkan hasil analisis properti jaringan sosial, Gopay memiliki node 4.021 dan edge 2.358 yang berarti bahwa tidak semua node (users) terhubung satu sama lain. Ini berarti bahwa pengguna yang berbicara tentang promosi penjualan Gopay kurang aktif dalam percakapan karena jumlah jaringan atau hubungan kurang dari jumlah node. Gopay memiliki diameter 14, semakin kecil diameter maka informasinya lebih cepat disebarluaskan. Tingkat keterhubungan Jaringan sosial Gopay adalah 1.175 yang berarti bahwa satu node hanya memiliki nilai keterhubungan kepada 1 simpul lainnya dalam jaringan. Dan rata – rata nilai panjang jalur adalah 5,07 menunjukkan jarak informasi untuk mencapai simpul lain adalah 5 hop.