bluuebunny/crossref_metadata_2025_split huggingface dataset:
Checkpoint protein expression in the tumor microenvironment defines the outcome of classical Hodgkin lymphoma patients
Authors: Karihtala Kristiina , Leivonen Suvi-Katri , Karjalainen-Lindsberg Marja-Liisa , Chan Fong Chun , Steidl Christian , Pellinen Teijo , Leppä Sirpa 
Published: December 2021

Abstract
Emerging evidence indicates a major impact for the tumor microenvironment (TME) and immune escape in the pathogenesis and clinical course of classical Hodgkin lymphoma (cHL). We used gene expression profiling (n = 88), CIBERSORT, and multiplex immunohistochemistry (n = 131) to characterize the immunoprofile of cHL TME and correlated the findings with survival. Gene expression analysis divided tumors into subgroups with T cell-inflamed and -noninflamed TME. Several macrophage-related genes were upregulated in samples with the non–T cell-inflamed TME, and based on the immune cell proportions, the samples clustered according to the content of T cells and macrophages. A cluster with high proportions of checkpoint protein (programmed cell death protein 1, PD-1 ligands, indoleamine 2,3 dioxygenase 1, lymphocyte-activation gene 3, and T-cell immunoglobulin and mucin domain containing protein 3) positive immune cells translated to unfavorable overall survival (OS) (5-year OS 76% vs 96%; P = .010) and remained an independent prognostic factor for OS in multivariable analysis (HR, 4.34; 95% CI, 1.05-17.91; P = .043). cHL samples with high proportions of checkpoint proteins overexpressed genes coding for cytolytic factors, proposing paradoxically that they were immunologically active. This checkpoint molecule gene signature translated to inferior survival in a validation cohort of 290 diagnostic cHL samples (P &lt; .001) and in an expansion cohort of 84 cHL relapse samples (P = .048). Our findings demonstrate the impact of T cell- and macrophage-mediated checkpoint system on the survival of patients with cHL.
Three-dimensional oropharyngeal airway changes after facemask therapy using low-dose computed tomography: a clinical trial with a retrospectively collected control group
Authors: Husson Amr H. , Burhan Ahmad S. , Hajeer Mohammad Y. , Nawaya Fehmieh R. 
Published: December 2021

Abstract
Aims
This study aimed to evaluate the short-term oropharyngeal airway volumetric changes in growing Class III maxillary-deficient patients treated by facemask without expansion compared with untreated Class III controls, using low-dose computed tomography.

Methods
Eighteen maxillary-deficient children (9 boys, nine girls) with a mean age of 7.81 ± 0.84 years were treated with maxillary bonded bite block and facemask (FM). Pre- (T1) and post-treatment (T2) low-dose CT images were acquired. Sixteen untreated Class III patients with a mean age of 7.03 ± 0.56 years had previously two low-dose CT scans within a one year of follow-up. Volumetric and minimal cross-sectional area measurements were obtained to assess the oropharyngeal airway changes. Quantitative mean, minimum, and maximum displacement of superimposed 3D models were estimated from a point-based analysis. Paired-samples t-tests were used for the intragroup comparisons, and an independent samples t-test and the Mann–Whitney U tests were carried out for the intergroup comparisons.

Results
A statistically significant increase in the total and retropalatal volumes oropharyngeal airway volume were observed in the control group (302.23 ± 345.58 and 145.73 ± 189.22 mm3, respectively). In the FM group, statistically significant increases in the total and retropalatal volumes were observed (738.86 ± 1109.37 mm3 and 388.63 ± 491.44 mm3, respectively). However, no statistically significant differences were found between the two groups, except for the maximum part analysis which was significantly greater in the FM group (p = 0.007).

Conclusions
FM therapy appeared to have no additional effects on the oropharyngeal airway other than those induced by growth.
Rehabilitation care planning on a digital communication platform for patients with a work disability: protocol for the RehaPro-SERVE feasibility study
Authors: van der Wardt Veronika , Seipp Hannah , Becker Annette , Maulbecker-Armstrong Catharina , Kraicker Rebecca , Schneider Annika , Heitz Andreas , Seifart Ulf 
Published: December 2021

Abstract
Background
Long-term disability to work is a risk factor for a permanent reduction in income. Rehabilitation care can support people to return to work. In Germany, rehabilitation care to return to work is mostly provided in specialised clinics. The aim of the Rehapro-SERVE study is to reduce work disability days by facilitating rehabilitation care planning using a digital communication platform. To investigate the feasibility, we will test the implementation of the digital platform and evaluate the study procedures. The Rehapro-SERVE study is funded by the German Federal Ministry of Labour and Social Affairs (BMAS) (grant number: 661R0053K1).

Method
The feasibility study includes a two-armed unblinded block randomised controlled study (RCT) without follow-up assessments as well as an interview study. Participants for the RCT (n = 16) are primary care patients with a minimum of 4 weeks of absence from work due to musculoskeletal, oncological or psychological conditions and at high risk of early retirement. Eligibility criteria are age 40 to 60 years; minimum of 4 weeks continuous sick leave before recruitment due to musculoskeletal, mental health or oncological conditions; and being at high risk of early retirement. Patients will be recruited from 8 primary care practices in urban and rural areas in Hesse, Germany. Following baseline assessments, patients will be randomised to either digitalised care planning (treatment) or a control group. The digitalised care planning platform will include the patients’ primary care physicians, jobcentres and public health physicians to decide on a tailored return-to-work programme. The collaboration will be supported by a case administrator and, if considered beneficial, a social worker for the patient. An interview study will evaluate the acceptability of the study procedures and the intervention.

Discussion
The use of a digital communication platform enables stakeholders to exchange information and discuss rehabilitation care planning in a timely fashion. The results of the feasibility study will lead to the adaptation of study procedures for the main study. The results will support the design and conduct of similar studies including digital applications in primary care or across different healthcare settings.

Trial registration
DRKS- German Clinical Trials Register, DRKS00024207. Registered on 22 March 2021
TEM sample preparation of microsized LiMn2O4 powder using an ion slicer
Authors: Park Jung Sik , Kang Yoon-Jung , Choi Sun Eui , Jo Yong Nam 
Published: December 2021

AbstractThe main purpose of this paper is the preparation of transmission electron microscopy (TEM) samples from the microsized powders of lithium-ion secondary batteries. To avoid artefacts during TEM sample preparation, the use of ion slicer milling for thinning and maintaining the intrinsic structure is described. Argon-ion milling techniques have been widely examined to make optimal specimens, thereby making TEM analysis more reliable. In the past few years, the correction of spherical aberration (Cs) in scanning transmission electron microscopy (STEM) has been developing rapidly, which results in direct observation at an atomic level resolution not only at a high acceleration voltage but also at a deaccelerated voltage. In particular, low-kV application has markedly increased, which requires a sufficiently transparent specimen without structural distortion during the sample preparation process. In this study, sample preparation for high-resolution STEM observation is accomplished, and investigations on the crystal integrity are carried out by Cs-corrected STEM.
Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review
Authors: Walsh Zach , Mollaahmetoglu Ozden Merve , Rootman Joseph , Golsof Shannon , Keeler Johanna , Marsh Beth , Nutt David J. , Morgan Celia J. A. 
Published: December 2021

Background
In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric conditions.

Aims
In light of these findings surrounding ketamine's psychotherapeutic potential, we systematically review the extant evidence on ketamine's effects in treating mental health disorders.

Method
The systematic review protocol was registered in PROSPERO (identifier CRD42019130636). Human studies investigating the therapeutic effects of ketamine in the treatment of mental health disorders were included. Because of the extensive research in depression, bipolar disorder and suicidal ideation, only systematic reviews and meta-analyses were included. We searched Medline and PsycINFO on 21 October 2020. Risk-of-bias analysis was assessed with the Cochrane Risk of Bias tools and A Measurement Tool to Assess Systematic Reviews (AMSTAR) Checklist.

Results
We included 83 published reports in the final review: 33 systematic reviews, 29 randomised controlled trials, two randomised trials without placebo, three non-randomised trials with controls, six open-label trials and ten retrospective reviews. The results were presented via narrative synthesis.

Conclusions
Systematic reviews and meta-analyses provide support for robust, rapid and transient antidepressant and anti-suicidal effects of ketamine. Evidence for other indications is less robust, but suggests similarly positive and short-lived effects. The conclusions should be interpreted with caution because of the high risk of bias of included studies. Optimal dosing, modes of administration and the most effective forms of adjunctive psychotherapeutic support should be examined further.
Efeitos tóxicos à saúde humana e ao ambiente causados pelo derramamento de rejeitos de minério da barragem de Fundão
Authors: Oliveira Lara Luiza Freitas de , Santos Hélio Batista dos , Thomé Ralph Gruppi , Chequer Farah Maria Drumond 
Published: December 2021

Objetivo: analisar as evidências científicas existentes até o presente momento que descrevem os efeitos tóxicos causados à saúde humana e ao ambiente, devido à liberação dos rejeitos de minério, decorrentes do rompimento da barragem de Fundão em Mariana - MG. Métodos: a revisão narrativa da literatura baseou-se na busca de artigos em quatro bases de dados: PubMed, SciELO, Science Direct e LILACS, utilizando os descritores “Dam”, “Fundão” e “Mariana” junto com o operador booleano “AND”. Resultados: trinta e quatro das oitenta e cinco publicações encontradas atenderam aos critérios de inclusão e foram utilizadas para compor a presente revisão. Foram observados os seguintes efeitos tóxicos: contaminação da água e do solo, principalmente, por metais pesados, potencial genotóxico, citotóxico e mutagênico da água, diminuição da diversidade microbiana, contaminação de peixes, perda da vegetação e prejuízos ao metabolismo de crescimento de plantas. Entre esses metais, foi relatado aumento na concentração de ferro, manganês, cobre, cádmio, chumbo, arsênio, cromo, magnésio, alumínio, mercúrio, cobalto, bário, níquel e selênio. Além disso, o desastre promoveu o aumento no número de casos de doenças humanas, como dengue, doenças respiratórias, dermatológicas, intestinais, psicológicas e comportamentais. Conclusão: todas as evidências científicas expostas na presente revisão sugerem que houve a contaminação ambiental, bem como da população local, por agentes tóxicos presentes nos rejeitos de minério, em especial metais pesados, liberados após o rompimento da barragem de Fundão. Assim, torna-se essencial a realização de mais estudos que visem esclarecer os efeitos tóxicos crônicos decorrentes dos rejeitos de minério liberados ao ambiente.
Comparison between different methods of calculating Kt/V as the marker of adequacy of dialysis
Authors: Mateen Fazl e , Ahmad Sajad , Elahi Irfan , Anees Muhammad 
Published: December 2021

Objectives: To compare different methods of calculating adequacy of hemodialysis in terms of Kt/V.
Methods: This was an observational, quantitative study undertaken after the approval of Internal Review Board at the Hemodialysis Unit of Nephrology department, Mayo Hospital, Lahore from 1st December 2018 to 30th June 2019. Sixty hemodynamically stable patients of end stage renal disease undergoing hemodialysis for more than three months with age 18 to 70 years were included in the study by convenience non probability sampling. Critically ill patients with multiple co-morbidities like sepsis (i.e. total leukocyte count >11000 or <4000 x 109/L), ischemic heart disease, pace- makers, malignancies, cirrhosis etc were excluded. Patients who were not adherent to dialysis prescription or hemodynamically unstable were also excluded. One way ANOVA and Pearson’s correlation were used to find correlation between three methods of measuring Kt/V.
Results: Mean ultrafiltration was 2.1+ 0.76 liter/session. Pre dialysis weight was 64.7 +14.7 kgs, mean post dialysis weight was 62.5 + 14.7 kgs. For every patient blood flow rate was 300 ml/m and dialysis flow rate was 500 ml/min. The mean values of Kt/V measured by Daugirdas formula was 1.35 ± 0.33, mean online clearance monitoring (OCM) value was 1.17 ± 0.29 and by normogram was 1.36 ± 0.33. There was positive significant correlation between values of Daugirdas formula, Normogram and online clearance monitoring (OCM) i.e. r = 0.897 (p-value < 0.001) measured by Pearson’s correlation and one way-ANOVA.
Conclusion: Online clearance monitoring can be used for measuring adequacy of hemodialysis, but OCM slightly underestimates Kt/V as compared to Daugirdas formula and Normogram.
doi: https://doi.org/10.12669/pjms.38.1.4281
How to cite this:Fazl-e-Mateen, Ahmad S, Elahi I, Anees M. Comparison between different methods of calculating Kt/V as the marker of adequacy of dialysis. Pak J Med Sci. 2022;38(1):167-171. doi: https://doi.org/10.12669/pjms.38.1.4281
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Holenderski Podręcznik do porządkowania i opisu archiwów autorstwa S. Mullera, J. Feitha i R. Fruina z 1898 roku i jego późniejsze wydania
Authors: Nowak Łukasz Piotr 
Published: December 2021

Wydany w 1898 r. holenderski Podręcznik do porządkowania i opisu archiwów S. Mullera, J. Feitha i R. Fruina jest jedną z najbardziej przełomowych publikacji w historii archiwistyki. Książka jako jedna z pierwszych na świecie podaje szczegółowe wskazówki odnośnie do organizacji archiwów i pracy archiwistów, a jej autorzy mieli na celu ujednolicenie zasad panujących w archiwach europejskich. Dzięki tłumaczeniom dokonanym na języki obce podręcznik wzbudził szerokie zainteresowanie poza Holandią i wywołał dyskusję na temat zasadności stosowania w archiwach zasady proweniencji. Ostatecznie stał się również motorem napędowym do jej przyjęcia przez większość europejskich archiwów, czego wyrazem była uchwała w tej sprawie podjęta na I Międzynarodowym Kongresie Archiwistów i Bibliotekarzy w Brukseli w 19010 r. Artykuł odpowiada na pytania o to, jaki był kontekst historyczny napisania podręcznika, jakie motywy kierowały autorami przy pisaniu poszczególnych rozdziałów i jaki był przebieg prac edytorskich. Dalsza część tekstu zawiera prezentację i analizę treści przedstawionych w książce. Ostatnia część artykułu stanowi krótkie omówienie kontekstu powstania poszczególnych wydań podręcznika oraz zawiera wykaz jego tłumaczeń na języki obce.
Prawdziwa depresja i paternalizm kliniczny: etnografia realności diagnostycznej depresji w publicznej służbie zdrowia w Polsce
Authors: Sokół Grzegorz 
Published: December 2021

Artykuł jest etnograficznym studium procesów diagnostycznych zaburzeń depresyjnych we współczesnej Polsce i ich zmian po transformacji ustrojowej, ze szczególnym uwzględnieniem strategii podejmowanych przez lekarzy. Opierając się na badaniach etnograficznych prowadzonych w kontekstach klinicznych, artykuł omawia problem relacji między kategoriami diagnostycznymi a ich przedmiotami, odwołując się do pojęć realności i urealnienia. O ile zmiany klasyfikacji diagnostycznej od lat 90. XX wieku miały na celu zacieśnienie tej relacji, o tyle w praktyce klinicznej pozostaje ona luźna i nieoczywista. Przyczyniają się do tego nie tylko specyficzna ontologia zaburzeń psychicznych, którą trudno w pełni sprowadzić do obiektywnie wymierzalnych objawów, ale także kilka innych czynników: specyficzne zmiany w filozofii klasyfikacji diagnostycznych, wielowymiarowość diagnoz jako narzędzi klinicznych, administracyjnych i finansowych, oraz ich referencyjna natura, konotująca optymalne, choć nieosiągalne standardy opieki. Wpływa na to także pragmatyka pracy klinicznej i ograniczone zasoby samych pacjentów, które czynią z diagnoz narzędzie nieformalnych, instrumentalnych działań i „paternalizmu medycznego” lekarzy w odpowiedzi na braki w systemie opieki.
Wyzwolenie obozu koncentracyjnego Bergen-Belsen (1945). Relacje świadków
Authors: Gardocki Wiktor 
Published: December 2021

Obóz koncentracyjny Bergen-Belsen został wyzwolony przez Brytyjczyków 15 kwietnia 1945 roku. W ciągu kilku następnych tygodni próbowano ratować przetrzymywane tam osoby, jednak w wielu wypadkach się to nie udało. Pierwsze dni w dawnym obozie zostały opisane przez reporterów, fotografów czy personel medyczny, jak również byłych więźniów. Z raportów, zapisków i innych dokumentów sporządzanych na bieżąco, a także ze wspomnień napisanych w latach powojennych wyłania się rzeczywisty, tragiczny stan niemieckiego obozu w kwietniu 1945 roku.
W prezentowanym artykule zestawiono relacje świadków: zarówno ocalonych, jak i ludzi, którzy do ich uwolnienia się przyczynili, próbując ukazać, jak wyglądało wyzwolenie obozu, a także jak wyglądała sytuacja w nim panująca w następnych miesiącach. W tekście przywołano materiały archiwalne odnalezione podczas kwerendy przeprowadzonej w 2019 i 2020 roku w Yad Vashem. The World Holocaust Remebrnce Center w Jerozolimie oraz Żydowskim Instytucie Historycznym w Warszawie.
Damaris Masham, Ralph Cudworth and John Locke: Some Philosophical Continuities
Authors: Hutton Sarah 
Published: December 2021

In this paper, I focus on Damaris Masham, to re-consider the relationship of her philosophy to the two philosophers with whom she was most closely associated: John Locke, and her father, the Cambridge Platonist, Ralph Cudworth. After considering some of the problems of interpretation which have arisen in scholarly debates, I focus her Occasional Thoughts to highlight continuities with both Locke and Cudworth in her epistemology, moral philosophy and metaphysics. I argue these show that Damaris Masham’s philosophy does not fit the received categories of empiricist or rationalist of the dominant narrative. Her position requires us to reconsider not just the relationship of her philosophy to that of Cudworth and Locke, but also of the relationship of Cudworth and Locke. Ultimately, therefore, reintegrating women into the history of philosophy challenges us to rethink standard narratives of the history of philosophy.
Głusi i tłumacze PJM o tłumaczeniu języka migowego w Polsce kiedyś i dziś
Authors: Kalata-Zawłocka Aleksandra 
Published: December 2021

Sign Language Interpreting in the Opinions of Deaf Persons and Polish Sign Language Interpreters
The article presents the results of a research conducted among 12 deaf people and 11 Polish sign language interpreters, aimed at depicting the state-of-the-art situation of sign language interpreting in Poland while it simultaneously reflects upon the past as well. The interviewees reported on the changes in this area over the last twenty-five years. According to them, situation in Poland has improved significantly with regard to language, interpreting as such, legal-administrative and social issues. Still, in many respects sign language interpreting needs further improvement in order to attain full accessibility for deaf persons as well as full professionalisation for sign language interpreters.
Słownictwo obozowe w przekładzie ustnym na terenie Państwowego Muzeum Auschwitz-Birkenau w opiniach tłumaczy i hiszpańskojęzycznych zwiedzających
Authors: Paleczna Marta 
Published: December 2021

Nazi Concentration Camp Vocabulary in Oral Interpreting in the Auschwitz-Birkenau State Museum in the Opinion of Interpreters and Spanish-Speaking Visitors
The article presents some of the results obtained as part of multi-stage research project that was carried out in 2018-2020. Its purpose was to collect information on interpreting performed for visitors at the Auschwitz- Birkenau State Museum. The article discusses the difficulty of translating the camp vocabulary when performing the above-mentioned interpreting. Thirty interpreters shared their views on the oral translation as well as 96 visitors, for whom the information during the tour was provided by a Spanish speaking interpreter.
In Search of Inspiration: External Mobility and the Emergence of Technology Intrapreneurs
Authors: Ng Weiyi , Sherman Eliot L. 
Published: December 2021

Recent scholarship has established several ways in which external hiring—versus filling a role with a comparable internal candidate—is detrimental to firms. Yet, organizational learning theory suggests that external hires benefit firms: by importing knowledge that is unavailable or obscured to insiders and applying it toward experimentation and risky recombination. Accordingly and consistent with studies of learning by hiring and innovation, we predict that external hires are at greater risk of intrapreneurship than internal hires. We test this prediction via a study of product managers in large technology companies. We use machine learning to operationalize intrapreneurship by comparing product manager job descriptions with the founding statements of venture-backed technology entrepreneurs. Our research design employs coarsened exact matching to balance pretreatment covariates between product managers who arrived at their roles internally versus externally. The results of our analysis indicate that externally hired product managers are substantially more intrapreneurial than observably equivalent internal hires. However, we also find that intrapreneurial product managers have a higher turnover rate, an effect that is primarily driven by external hires. This suggests that hiring for intrapreneurship may be a difficult strategy to sustain.Funding: The authors acknowledge financial support from London Business School, the National University of Singapore [Grant WBS R-313-000-128-133], and a dissertation grant from the Ewing Kauffman Foundation, Kansas City, Missouri.Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2021.1530 .