bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent-Adolescent Discussion on Sexual and Reproductive Health Issues and Its Associated Factors Among Parents in Sawla Town, Gofa Zone, Ethiopia
Authors: Malango Nigatu Teferi , Hegena Tadele Yohannes , Assefa Netsanet Abera 
Published: December 2021

Abstract
Background: Parent-adolescent discussion on sexual and reproductive health (SRH) issues leads to increased awareness on reproductive health matters and reduces risky behaviors among adolescents and also is the base to reduce depraved reproductive health outcomes. The aim of this study was to assess parent-adolescent discussion on SRH issues and its associated factors in Sawla town, Southern Ethiopia, 2020. Methods: A community based cross sectional study was conducted among parents in Sawla town from March to April 2020. A simple random sampling technique was employed to select 697 study subjects. Data were entered in to Epi-data version 3.1 and exported to SPSS version 21 for analysis. Variables with p-value less than 0.25 in bivariate analysis were entered into multiple logistic regression models to test for association with the dependent variable at 95 % confidence level (CI). P-value less than 0.05 and 95 % CI for adjusted odds ratios (AOR) were used to declare the significance of the associations with the outcome variable.Results: Of the total participants, 168 (25.7%) respondents had reported discussion about at least two components of SRH issues in the last six months prior to the study. Multiple logistic regression model revealed that parents who attended primary education (AOR 3, 95% CI: 1.10, 7.70), secondary education (AOR 9, 95% CI: 3.87, 20.64) and diploma and above (AOR 22.33, 95% CI: 9.49, 32.56), monthly income of above 2000 Ethiopian Birr (AOR 2.40, 95% CI: 1.30, 4.55), good knowledge (AOR 2, 95% CI: 1.14, 3.50)and positive attitude (AOR 4, 95% CI: 1.57, 10) towards SRH issues were statically significant with parent to adolescent discussion.Conclusion: The occurrence of parent-adolescent SRH discussion is low in Sawla town. Educational status, average monthly income, knowledge and attitude on SRH issues were major factors affecting parent-adolescent discussion on SRH issues. Continuous capacity building on SRH issues for parents to increase the level of parental knowledge and attitude about SRH issues and sustainable advocacy should be provided about the importance of parent to adolescent discussion. Moreover, it is important to support and scale up the adult learning program to decrease the level of illiteracy.
Genetic-Quantitative Uni- and Bi-Trait Analysis for Growth Traits in the Colombian Creole Breed Blanco Orejinegro (BON)
Authors: Londoño-Gil Marisol , Flórez Juan Carlos Rincón , López-Herrera Albeiro , Gonzalez-Herrera Luis Gabriel 
Published: December 2021

Abstract
The Blanco Orejinegro (BON) is a Colombian creole cattle breed that is not genetically well characterized for growth traits. The aim of this work was to estimate genetic parameters for birth weight (BW), weaning weight (WW), yearling weight (YW), daily weight gain between birth and weaning (DWG), time to reach 120 kg of live weight (T120), and time to reach 60% of adult weight (T60%), and establish the selection criteria for growth traits in the BON population of Colombia. Genealogical and phenotypic information for BW, WW, YW, DWG, T120, and T60% traits of BON animals from 14 Colombian herds were used. These traits were analyzed with the AIREML method in a uni- and bi-trait animal model including the maternal effect for BW, WW, DWG, and T120. The direct heritability estimates values were 0.22 ± 0.059 (BW), 0.20 ± 0.057 (WW), 0.20 ± 0.153 (YW), 0.17 ± 0.07 (DWG), 0.26 (T120), and 0.44 ± 0.03 (T60%). The maternal heritability estimates values were 0.14 ± 0.040 (BW), 0.15 ± 0.039 (WW), 0.25 ± 0.06 (DWG), and 0.16 (T120). The direct genetic correlations were high (>|0.60|) among all the traits, except between T60% with BW, WW, YW, and DWG (ranged from -0.02 to -0.51), all in a favorable direction. The results showed that there is genetic variation in the growth traits associated with the additive genetic effect and they might respond to selection processes. Furthermore, genetic gains would improve through selection, especially for YW and T60% when WW is used as criterion.
Research on Dual-Wavelength Absolute Ranging Technology Based on FMCW Laser Interference
Authors: Sun Bin , Song Junfang 
Published: December 2021

Abstract
FMCW (Frequency-Modulated Continuous Wave) interferometer can achieve high-precision displacement measurement by phase discrimination of the interference signal. The phase needs to be superimposed continuously, so the optical path cannot be interrupted in the measurement process. To solve this problem, a new absolute ranging technology - decimal comparison method is proposed in the manuscript. According to the principle of FMCW interference, two DFB lasers with different central wavelengths are used to measure the same target. The sampled interference signal is processed by digital signal processing to calculate the integer and decimal of the synthetic wavelength period. The optical path difference of the target is calculated by the established mathematical model. The experimental results show that this method not only ensures the measurement accuracy, but also realizes the absolute measurement, and expands the application range of FMCW interferometry.
Metabolic Equivalents of Safe Physical Activity Levels at Anaerobic Threshold in Anorexia Nervosa Patients
Authors: Makoto Yamashita , Keisuke Kawai , Kenta Toda , Chie Aso Suzuyama , Takafumi Suematsu , Hiroaki Yokoyama , Tomokazu Hata , Shu Takakura , Nobuyuki Sudo 
Published: December 2021

Abstract
Purpose Patients with anorexia nervosa (AN) require appropriate nutrient therapy and physical activity management. Eating disorder treatment guidelines do not include safe, evidence-based intensity criteria for exercise. This study used cardiopulmonary exercise testing (CPX) to evaluate the exercise tolerance of patients with AN and develop treatment guidelines to optimize their physical activity. Methods CPX was done with 14 female AN patients admitted to a specialized eating disorder unit between 2015 and 2019. Their anaerobic threshold (AT) was determined by assessing their exercise tolerance using CPX and compared with 14 healthy controls (HC). The metabolic equivalents (AT-METS) were compared when AT was reached. We examined factors related to AT (AN-AT) in the AN group, including age, body mass index (BMI), previous lowest weight, minimum BMI, past duration of BMI < 15, exercise history, and ΔHR (heart rate at the AT - resting heart rate). Results The AT of the AN group (BMI: 15.7 [Mean] ± 1.8 [SD]) was significantly lower than the HC group (BMI: 19.7 ± 1.8) (AN: 10.0 ± 1.8 vs HC: 15.2 ± 3.0 ml/kg/min, P<0.001). AT-METS was also significantly lower in the AN than the HC group (AN: 2.9 ± 0.52 vs HC: 4.4 ± 0.91, P<0.001). AN-AT was highly influenced by ΔHR. Conclusion The AT-METS level for these AN patients was 2.5-3.3 METS, and this index can be used by clinicians to teach AN patients a safe exercise intensity. CPX and AT-METS are useful tools for clinicians to manage physical activity in AN patients. Level of evidence III: Evidence obtained from case-control analytic studies
Public Health and Social Measures to Mitigate the Health and Economic Impact of the COVID-19 Pandemic in Turkey, Egypt, Ukraine, Kazakhstan, and Poland During 2020-2021: Situational Analysis
Authors: Kitamura Noriko , Abbas Kaja , Nathwani Dilip 
Published: December 2021

Abstract
Background

The COVID-19 pandemic had enormous impacts on human society. There were similarities and differences in the public health and social measures taken by countries, and comparative analysis facilitates cross-country learning of contextual practices and sharing lessons to mitigate the COVID-19 pandemic impact. We aim to conduct a situational analysis of the public health and social measures to mitigate the health and economic impact of the COVID-19 pandemic in Turkey, Egypt, Ukraine, Kazakhstan, and Poland during 2020-2021.
Methods

We conducted a situational analysis of the COVID-19 pandemic response in Turkey, Egypt, Ukraine, Kazakhstan, and Poland from the perspectives of the health system and health finance, national coordination, surveillance, testing capacity, health infrastructure, healthcare workforce, medical supply, physical distancing and non-pharmaceutical interventions, health communication, impact on non-COVID-19 health services, impact on the economy, education, gender and civil liberties, and COVID-19 vaccination.
Results

Since the onset of the COVID-19 pandemic, Turkey, Egypt, Ukraine, Kazakhstan, and Poland have expanded COVID-19 testing and treatment capacity over time. However, they faced a shortage of healthcare workforce and medical supplies. They took population-based quarantine measures rather than individual-based isolation measures, which significantly burdened their economies and disrupted education. The unemployment rate increased, and economic growth stagnated. Economic stimulus policy was accompanied by high inflation. Despite the effort to sustain essential health services, healthcare access declined. Schools were closed for 5-11 months. Gender inequality was aggravated in Turkey and Ukraine, and an issue was raised for balancing public health measures and civil liberties in Egypt and Poland. Digital technologies played an important role in maintaining routine healthcare, education, and public health communication.
Conclusions

The COVID-19 pandemic has exposed weaknesses in healthcare systems in emerging countries of Turkey, Egypt, Ukraine, Kazakhstan, and Poland, and highlighted the intricate link between health and economy. Individual-level testing, isolation, and contact tracing are effective public health interventions in mitigating the health and economic impact of the COVID-19 pandemic in comparison to population-level measures of lockdowns. Investment in health, including digital health and communication, is essential to minimize the impact of the pandemic and for more equitable and sustainable development beyond the pandemic.
FRET-FISH probes chromatin compaction at individual genomic loci in single cells
Authors: Mota Ana , Wernersson Erik , Li-Wang Xiaoze , Gradin Katarina , Crosetto Nicola , Bienko Magda 
Published: December 2021

Abstract
The density or compaction of chromatin throughout the cell nucleus is a key biophysical property that influences DNA replication, transcription, and repair. Chromatin accessibility is often used as a proxy for chromatin compaction or density, however it is not clear how these two properties relate to each other, given the lack of tools for directly probing compaction at defined genomic loci. To fill in this gap, here we developed FRET-FISH, a microscopy-based method combining fluorescence resonance energy transference (FRET) with DNA fluorescence in situ hybridization (FISH) to probe chromatin compaction at selected loci in single cells. We optimized FRET-FISH by testing different probe designs in situ in fixed cells, readily detecting FRET generated by DNA FISH probes. To validate FRET-FISH, we compared it with ATAC-seq and Hi-C, demonstrating that local chromatin compaction and accessibility are strongly correlated and that the frequency of intra-genic contacts measured by Hi-C may be an even better proxy for local chromatin density. To further validate FRET-FISH, we showed that it can detect expected differences in chromatin compaction along the nuclear radius, with peripheral loci being more compacted and central ones less compacted. Lastly, we assessed the sensitivity of FRET-FISH, demonstrating its ability to reproducibly detect differences in chromatin density (i) upon treatment of cells with drugs that perturb global chromatin condensation; (ii) during prolonged cell culture; and (iii) in different phases of the cell cycle. We conclude that FRET-FISH is a robust tool for probing chromatin compaction at selected loci in single cells and for studying inter-allelic and cell-to-cell variability in chromatin density.
Diagnostic Agreement of Quantitative Flow Ratio with Fractional Flow Reserve in a Latin-American Population
Authors: Pinto Mauro Echavarria , de Hoef Tim P. Van , Pacheco-Beltran Nancy , Reyes-Carrera Jesus Eduardo , Rangel-Alvarado Eduardo , Ledezma-Ledezma Elizabeth , Aguilar-Castillo Laura Alicia , Tovar-Becerra Andrea Itzel , Arellano Juan Ernesto Muñoz , Ramírez María Neftalí Maqueda , Ibarra-Rangel Ana Maria , Montes-Collantes Carlos Alberto , Castrejon-Mora Jorge Luis , Benitez Irma Hualtal Chong , Vargas-Torrrescano Luis Homero , García-García Hector M. 
Published: December 2021

Abstract
Purpose: Quantitative flow ratio (QFR) is a recently proposed angiographic index that allows to assess the pressure loss in coronary arteries in a similar fashion as the accepted standard fractional flow reserve (FFR). The purpose of this study was to evaluate the diagnostic performance of QFR as compared to FFR, in a Latin-American population of patients with suspected ischaemic heart disease.Methods: QFR was retrospectively derived from coronary angiograms. The association, diagnostic performance, and continuous agreement of fixed-flow QFR (fQFR) and contrast-flow QFR (cQFR) with FFR was assessed by continuous and dichotomous methods.Results: 90 vessels form 63 patients were finally included. The study comprised coronary stenoses of intermediate severity, both angiographically (diameter stenosis: 46.6 ± 12.8%) and physiologically [median FFR=0.86 (quartile 1-3, 0.76-0.89)]. The correlation of FFR with both fQFR [ρ=0.841, (95% CI: 0.767 to 0.893), p<0.001] and cQFR [ρ=0.833, (95% CI: 0.755 to 0.887), p<0.001] was strong. The diagnostic performance of cQFR was numerically better [area under the ROC curve of 0.92 (95% CI: 0.86 to 0.97, p<0.001)], with 0.80 as the optimal cQFR cut-off against FFR≤0.80. This 0.80 cQFR cut-off classified correctly 83.3% of total stenoses, with a sensitivity of 85.2% and specificity of 80.6%.Conclusions: QFR was strongly associated with FFR and exhibited a high diagnostic performance in this Latin-American population.
Family Planning Films: Fact or Fiction? A Qualitative Study Assessing Changes in Knowledge, Attitudes, and Intentions to use Family Planning After Watching Documentary and Drama Health Education Films
Authors: MUBANGIZI VINCENT , Plastow Jane , Nakaggwa Florence , Nahabwe Haeven , Natukunda Sylvia , Atim Fiona , Mawere Brenda , Laughton Matthew , Muller Ingrid , Owokuhaisa Judith , Coates Sabine , Chambers Isabella , Goodhart Clare , Willcox Merlin 
Published: December 2021

Abstract
Background: There is a paucity of literature on the effectiveness of drama or documentary films in changing knowledge, beliefs, attitudes, and behavior of people towards family planning. This study aimed to compare and assess the acceptability of health promotion films based on documentary or drama, and their effect on knowledge, attitudes, and intention to use family planning.Methods: We developed short documentary and drama films about contraceptive implants, using the person-based approach. Their acceptability was assessed in focus group discussions with younger women below 23 years, women over 23 years, men of reproductive age, and health workers in four different areas of Uganda (Bwindi/Kanungu, Walukuba/Jinja, Kampala, and Mbarara). Transcripts of the focus group discussions were analyzed using thematic analysis, to generate themes and examine the key issues. We assessed changes in knowledge, attitudes, and intentions to use family planning after watching the films. Results: Sixteen focus groups with 150 participants were carried out. Participants said that the documentary improved their knowledge and addressed their fears about side effects, myths, and implant insertion. The drama improved their attitudes towards the implant and encouraged them to discuss family planning with their partner. The final versions of the documentary and the drama films were equally liked. Conclusions: Viewing a short documentary on the contraceptive implant led to positive changes in knowledge, while a short drama improved attitudes and intentions to discuss the implant with their partner. The drama and documentary have complementary features, and most participants wanted to see both.
Mitochondrial And Myogenic Gene Expression Pathways Are Influenced By The Exercise Mimetic Formoterol In Human Myotubes
Authors: Duplanty Anthony A. , Zumbro Emily L. , Gordon Ryan A. , Guerin Gena D. , Brisebois Matthew F. , Sokoloski Matthew L. , Rigby Brandon R. 
Published: December 2021

Abstract
Background: Exercise is an effective treatment for establishing and maintaining skeletal muscle (SKM) health. The interconnected cascade of gene expression pathways related to myogenesis, mitochondrial homeostasis, and thyroid hormone metabolism are critical to SKM health. This in vitro study was conducted to investigate the effects of exercise mimetic (formoterol) stimulation on human SKM cell signaling during myogenesis, and to provide insight on potential targets for future studies exploring therapies for SKM atrophy.Methods: Human myoblasts were cultured and differentiated to evaluate the effects of exercise mimetic stimulation on gene expression during mid and late myogenesis. We characterized the expression of 24 genes related to myogenesis, mitochondrial biogenesis, thyroid hormone metabolism, and cellular homeostasis.Results: Formoterol stimulated the gene expression for SKM pathways related to mitochondrial biogenesis, thyroid metabolism, and cellular homeostasis. Additionally, formoterol resulted in a myogenic program that appears to favor prolonged myoblast proliferation and delayed myotube maturation.Conclusion: Robust, yet differential effects of exercise mimetic stimulation on gene expression during mid-myogenesis and at terminal differentiation were found. The results of our study support the groundwork for establishing further experiments utilizing exercise signaling as a therapeutic treatment in models targeting dysfunctional SKM cell growth.
Optimal Unambiguous Discrimination And Quantum Nonlocality Without Entanglement: Locking And Unlocking By Post-Measurement Information
Authors: Ha Donghoon , Kim Jeong San 
Published: December 2021

Abstract
The phenomenon of nonlocality without entanglement(NLWE) arises in discriminating multi-party quantum separable states. Recently, it has been found that the post-measurement information about the prepared subensemble can lock or unlock NLWE in minimum-error discrimination of non-orthogonal separable states. Thus it is natrual to ask whether the availability of the post-measurement information can influence on the occurrence of NLWE even in other state-discrimination stratigies. Here, we show that the post-measurement information can be used to lock as well as unlock the occurence of NLWE in terms of optimal nambiguous discrimination. Our results can provide a useful application for hiding or sharing information based on non-orthogonal separable states.
On the accuracy of emitter localization method based on multipath exploitation in realistic scenarios
Authors: Imran Md Abdullah Al , Arik Eray , Dalveren Yaser , Tabakcioglu Mehmet Baris , Kara Ali 
Published: December 2021

Abstract
This study aims to evaluate the accuracy of a method proposed for passive localization of radar emitters around irregular terrains with a single receiver in Electronic Support Measures (ESM) systems. Previously, only the theoretical development of the localization method was targeted by the authors. In fact, this could be a serious concern in practice since there is no evidence about its accuracy under the real data gathered from realistic scenarios. Therefore, firstly, an accurate ray-tracing algorithm is adapted to the method in order to enable its implementation in practice. Then, scenarios are determined based on the geographic information system (GIS) map generated to collect high resolution digital terrain elevation data (DTED) as well as realistic localization problems for radar emitters. Next, the improved method is tested with simulations, and thus, its performance is verified for practical implementation in Electronic Warfare (EW) context for the first time in the literature. Lastly, based on the simulation results, the performance bounds of the method are also discussed.
WITHDRAWN: Young and Old Leaves Physiological and Metabolite Profiles Analysis on Amino Acids and Organic Acids in Wild Soybean Seedlings Under Nitrogen Deficiency
Authors: Liu Yuan , Gao Shujuan , Hu Yunan , Zhang Tao , Guo Jixun , Shi Lianxuan 
Published: December 2021

Abstract
Background
As an important germplasm resource, wild soybean has good tolerance to complex stress environment stress. This study described the differences of physiological and metabolomic changes between common wild soybean (GS1) and the barren tolerance wild soybean (GS2) under low nitrogen (LN) stress.
Results
The result showed the barren tolerance wild soybean young leaves can maintain relatively stable chlorophyll content and increased the contents of Car;Photosynthetic rate and transpiration rate decreased significantly in in the barren tolerance wild soybean old leaves, but there was no significant change in young leaves; the barren tolerance wild soybean enhanced the enrichment of beneficial ion pairs such as zinc, calcium and phosphorus. The metabolism of amino acids and organic acids in the barren tolerance wild soybean old leaves was vigorous, a large number of beneficial amino acids such as GABA, asparagine and proline were enriched, and the metabolites related to TCA cycle were significantly increased.
Conclusion
the barren tolerance wild soybean can ensure the nitrogen supply of young leaves by inhibiting the photosynthetic response of old leaves; the relatively stable growth of young leaves also benefits from the effective transport and reuse of beneficial ions from old leaves; More importantly, the enhanced metabolism of specific amino acids and organic acids in GS2 old leaves seemed to play an important role in resisting LN stress. GABA and Asparagine played substantial roles in N storage, C/N balance, antioxidant defense and act as signaling molecule to help GS2 to resist LN stress. Difference organic acids in the old leaves of GS2 increased which could improve the utilization rate of N in the soil. In addition, the strength of fatty acids catabolism and TCA cycle in GS2 old leaves provided energy base for substance transport. The analysis of physiological and metabolite may provide a new perspective for revealing the importance of substance transport and reuse in different plant parts to resist abiotic stress.