bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized periodic orbits of the time-periodically forced Kepler problem accumulating at the center and of circular and elliptic restricted three-body problems
Authors: Zhao Lei 
Published: December 2021

AbstractIn this paper, we consider a time-periodically forced Kepler problem in any dimension, with an external force which we only assume to be regular in a neighborhood of the attractive center. We prove that there exist infinitely many periodic orbits in this system, with possible double collisions with the center regularized, which accumulate at the attractive center. The result is obtained via a localization argument combined with a result on $$C^{1}$$

C
1

-persistence of closed orbits by a local homotopy-stretching argument. Consequently, by formulating the circular and elliptic restricted three-body problems of any dimension as time-periodically forced Kepler problems, we obtain that there exist infinitely many periodic orbits, with possible double collisions with the primaries regularized, accumulating at each of the primaries.
Ridge-type roughness: from turbulent channel flow to internal combustion engine
Authors: von Deyn Lars H. , Schmidt Marius , Örlü Ramis , Stroh Alexander , Kriegseis Jochen , Böhm Benjamin , Frohnapfel Bettina 
Published: December 2021

AbstractWhile existing engineering tools enable us to predict how homogeneous surface roughness alters drag and heat transfer of near-wall turbulent flows to a certain extent, these tools cannot be reliably applied for heterogeneous rough surfaces. Nevertheless, heterogeneous roughness is a key feature of many applications. In the present work we focus on spanwise heterogeneous roughness, which is known to introduce large-scale secondary motions that can strongly alter the near-wall turbulent flow. While these secondary motions are mostly investigated in canonical turbulent shear flows, we show that ridge-type roughness—one of the two widely investigated types of spanwise heterogeneous roughness—also induces secondary motions in the turbulent flow inside a combustion engine. This indicates that large scale secondary motions can also be found in technical flows, which neither represent classical turbulent equilibrium boundary layers nor are in a statistically steady state. In addition, as the first step towards improved drag predictions for heterogeneous rough surfaces, the Reynolds number dependency of the friction factor for ridge-type roughness is presented.Graphic abstract
Comment on “Free surface tension in incompressible smoothed particle hydrodynamics (ISPH)” [Comput. Mech. 2020, 65, 487–502]
Authors: Thiery Fabian , Fritz Fabian , Adams Nikolaus A. , Adami Stefan 
Published: December 2021

AbstractWe comment on a recent article [Comput. Mech. 2020, 65, 487–502] about surface-tension modeling for free-surface flows with Smoothed Particle Hydrodynamics. The authors motivate part of their work related to a novel principal curvature approximation by the wrong claim that the classical curvature formulation in SPH overestimates the curvature in 3D by a factor of 2. In this note we confirm the correctness of the classical formulation and point out the misconception of the commented article.
Vadose zone modeling to identify controls on groundwater recharge in an unconfined granular aquifer in a cold and humid environment with different meteorological data sources
Authors: Bruneau Sabrina , Barbecot Florent , Larocque Marie , Horoi Viorel , Coquet Yves , Guillon Sophie 
Published: December 2021

AbstractGroundwater recharge (GR) is a complex process that is difficult to quantify. Increasing attention has been given to unsaturated zone modeling to estimate GR and better understand the processes controlling it. Continuous soil-moisture time series have been shown to provide valuable information in this regard. The objectives of this study were to (i) analyze the processes and factors controlling GR in an unconfined granular aquifer in a cold and humid environment and (ii) assess the uncertainties associated with the use of data from different sources. Soil moisture data monitored over three years at three experimental sites in southern Quebec (Canada) were used to calibrate the HYDRUS-1D model and to estimate ranges of possible GR in a region where groundwater is increasingly used as a source of fresh water. The simulations identified and quantified important factors responsible for the near-surface water balance that leads to GR. The resulting GR estimates from 2016 to 2018 showed marked differences between the three sites, with values ranging from 347 to 735 mm/y. Mean GR for the three sites was 517 mm/y for 2016–2018 and 455 mm/y for the previous 12-year period. GR was shown to depend on monthly variations in precipitation and on soil textural parameters in the root zone, both controlling soil-water retention and evapotranspiration. Monthly recharge patterns showed distinct preferential GR periods during the spring snowmelt (38–45% of precipitation) and in the fall (29% of precipitation). The use of different meteorological datasets was shown to influence the GR estimates.
Furfural Oxidation with Hydrogen Peroxide Over ZSM-5 Based Micro-Mesoporous Aluminosilicates
Authors: Shcherban Nataliya D. , Barakov Roman Yu. , Sergiienko Sergii A. , Eränen Kari , Wärnå Johan , Murzin Dmitry Yu. 
Published: December 2021

AbstractMicro-mesoporous aluminosilicates based on ZSM-5 zeolite, obtained by a dual template method, as well as in the presence of a dual-functional template (i.e. a Gemini-type surfactant), were tested in the oxidation of furfural with hydrogen peroxide. Even substantial changes in acidity and porosity of the catalysts result in minor variations of selectivity towards the desired products. Application of the synthesized zeolite-based materials in the oxidation of furfural with hydrogen peroxide leads to formation of 2(5H)-furanone (yield up to 28.5%) and succinic acid (up to 19.5%) as the main C4 reaction products. The kinetic model developed previously to treat the results for oxidation of furfural over sulfated zirconia was able to describe the data also for micro-mesoporous aluminosilicates.
Graphical Abstract
Design and Feasibility Verification of 6G Wireless Communication Systems with State of the Art Technologies
Authors: Dilli Ravilla 
Published: December 2021

AbstractFrequencies above 100 GHz are the promising frequency bands for 6G wireless communication systems because of the abundant unexplored and unused spectrum. The increasing global demand for ultra-high spectral efficiencies, data rates, speeds and bandwidths in next-generation wireless networks motivates the exploration of peak capabilities of massive MIMO (Multi–Input–Multi–Output) wireless access technology at THz bands (0.1–10 THz). The smaller wavelengths (order of microns) of these frequencies give an advantage of making high gain antennas with smaller physical dimensions and allows massive spatial multiplexing. This paper presents the design of ultra-massive MIMO (ultra-mMIMO) hybrid beamforming system for multi users and its feasibility to function at THz frequency bands. The functionality of the proposed system is verified at higher order modulation schemes to achieve higher spectral efficiencies using performance metrics that includes error vector magnitude, symbol constellations, and antenna array radiation beams. The performance results suggest to use a particular mMIMO antenna configuration based on number of independent data streams per user and strongly recommended to use higher number of data streams per user in order to achieve higher throughputs that satisfy the needs of 6G wireless systems. Also the performance of the proposed system at 0.14 THz is compared with mmWave systems that operate at 28 GHz and 73 GHz bands to justify the feasibility of the proposed work.
African Asylum Seekers in Europe: The Interplay between Foreign Aid and Governance in Origin Countries
Authors: Ripollés Jordi , Martínez-Zarzoso Inmaculada 
Published: December 2021

AbstractThis paper empirically investigates the effects of governance quality on the number of African asylum seekers in Europe over the period 1996–2018 and evaluates the extent to which official development aid acts as a catalyst. With this purpose in mind, different gravity model specifications and estimation approaches have been employed. The obtained results suggest that the asylum flows are strongly determined by governance quality in the country of origin and that this effect does depend on the amount of foreign aid received from developed countries. Moreover, it is also found that development aid is only effective in reducing asylum applications coming from countries with good governance. Moreover, we find no differences in the estimated elasticity of foreign aid on asylum claims for the beneficiaries of the European Union Emergency Trust Fund (EUTF) for Africa, the main aim of which has been to improve living conditions of potential migrants in their countries of origin.
The melting properties of D-α-glucose, D-β-fructose, D-sucrose, D-α-galactose, and D-α-xylose and their solubility in water: A revision
Authors: Chua Yeong Zen , Do Hoang Tam , Kumar Aarti , Hallermann Moritz , Zaitsau Dzmitry , Schick Christoph , Held Christoph 
Published: December 2021

Abstract
Saccharides are still commonly isolated from biological feedstock by crystallization from aqueous solutions. Precise thermodynamic data on solubility are essential to optimize the downstream crystallization process. Solubility modeling, in turn, requires knowledge of melting properties. In the first part of this work, following our previous work on amino acids and peptides, D-α-glucose, D-β-fructose, D-sucrose, D-α-galactose, and D-α-xylose were investigated with Fast Scanning Calorimetry (FSC) in a wide scanning rate range (2000 K·s−1 to 10000 K·s−1). Using the experimental melting properties of saccharides from FSC allowed successfully modeling aqueous solubility for D-sucrose and D-α-galactose with the equation of state PC-SAFT. This provides cross-validation of the measurement methods to determine accurate experimental melting properties with FSC. Unexpectedly, the experimental FSC melting temperatures, extrapolated to zero scanning rates for thermal lag correction, were higher than results determined with DSC and available literature data. To clarify this inconsistency, FSC measurements towards low scanning rates from 10000 K·s−1 to 1 K·s−1 (D-α-glucose, D-β-fructose, D-sucrose) overlapping with the scanning rates of DSC and literature data were combined. At scanning rates below 1000 K·s−1, the melting properties followed a consistent non-linear trend, observed in both the FSC and the literature data. In order to understand the non-linear decrease of apparent melting temperatures with decreasing heating rate, the endothermic peaks were investigated in terms of isoconversional kinetics. The activation energies in the non-linear dependency region are in the range of $$300<{E}_{A}< 600 {\text{kJ}}\bullet {\text{mo}}{\text{l}}^{-1}$$

300
<

E
A

<
600
kJ
∙

mol

-
1

. These values are higher than the enthalpy of sublimation for D-α-glucose, indicating that the non-linear behavior does not have a physical nature but attributes to chemical processes corresponding to the decomposition of molecular compounds within the crystal lattice before melting. The melting properties reported in the literature, commonly determined with conventional methods such as DSC, lead to inaccurate results due to the decomposition of these biomolecules at low heating rates. In addition, the FSC results at lower scanning rates coincide with results from DSC and literature in the overlapping scanning rate range, further validating the accuracy of FSC measurements to determine reliable melting properties of thermally labile biomolecules. The experimental FSC melting properties determined at higher scanning rates are considered as the correct equilibrium melting properties, which are not influenced by any chemical processes. The combination of FSC and PC-SAFT opens the door to model solubility of solid compounds that commonly decompose before melting.
Neuronavigated repetitive transcranial magnetic stimulation as novel mapping technique provides insights into language function in primary progressive aphasia
Authors: Mueller-Sarnowski Felix , Sollmann Nico , Schröder Axel , Houri Leen , Ille Sebastian , Grimmer Timo , Krieg Sandro M. , Diehl-Schmid Janine 
Published: December 2021

AbstractNavigated repetitive transcranial magnetic stimulation (nrTMS) is an innovative technique that provides insight into language function with high accuracy in time and space. So far, nrTMS has mainly been applied in presurgical language mapping of patients with intracranial neoplasms. For the present study, nrTMS was used for language mapping in primary progressive aphasia (PPA). Seven patients (median age: 70 years, 4 males) with the non-fluent variant of PPA (nfvPPA) were included in this pilot study. Trains of nrTMS (5 Hz, 100% resting motor threshold) caused virtual lesions at 46 standardized cortical stimulation targets per hemisphere. Patients’ errors in a naming task during stimulation were counted. The majority of errors induced occurred during frontal lobe stimulation (34.3%). Timing errors and non-responses were most frequent. More errors were induced in the right hemisphere (58%) than in the left hemisphere (42%). Mapping was tolerated by all patients, however, discomfort or pain was reported for stimulation of frontal areas. The elevated right-hemispheric error rate in our study could be due to a partial shift of language function to the right hemisphere in neurodegenerative aphasia during the course of disease and therefore points to the existence of neuronal plasticity in nfvPPA. While this is an interesting finding for neurodegenerative disorders per se, its promotion might also harbor future therapeutic targets.
Anthracene modified graphene for C60/C70 fullerenes capture and construction of energy storage materials
Authors: Fedorczyk Agata , Krogul-Sobczak Agnieszka , Piotrowski Piotr 
Published: December 2021

AbstractGraphene functionalized with dianthracene malonate was synthesized and used subsequently for construction of covalently bound graphene-fullerene hybrid nanomaterials. For this purpose, novel approach of Diels–Alder reaction of C60/C70 fullerene cores with anthracene moieties previously introduced onto graphene surface was successfully employed. Structure and composition of obtained graphene and its derivatives were characterized using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and FT-IR spectroscopy. Obtained results revealed that both C60 and C70 fullerenes were found to be capable of formation desired Diels–Alder adducts, yielding products of different morphology. Capacitive properties of the synthesized energy storage nanomaterials were determined by means of cyclic voltammetry (CV) and galvanostatic charge/discharge (GCD) measurements, revealing that functionalization of graphene with C60 moieties enhances its energy storage properties.
Autophagy Inhibition Reduces Irradiation-Induced Subcortical White Matter Injury Not by Reducing Inflammation, but by Increasing Mitochondrial Fusion and Inhibiting Mitochondrial Fission
Authors: Wang Yafeng , Xu Yiran , Zhou Kai , Zhang Shan , Wang Yong , Li Tao , Xie Cuicui , Zhang Xiaoli , Song Juan , Wang Xiaoyang , Zhu Changlian 
Published: December 2021

Abstract
Radiotherapy is an effective tool in the treatment of malignant brain tumors, but irradiation-induced late-onset toxicity remains a major problem. The purpose of this study was to investigate if genetic inhibition of autophagy has an impact on subcortical white matter development in the juvenile mouse brain after irradiation. Ten-day-old selective neural Atg7 knockout (KO) mice and wild-type (WT) littermates were subjected to a single 6-Gy dose of whole-brain irradiation and evaluated at 5 days after irradiation. Neural Atg7 deficiency partially prevented myelin disruption compared to the WT mice after irradiation, as indicated by myelin basic protein staining. Irradiation induced oligodendrocyte progenitor cell loss in the subcortical white matter, and Atg7 deficiency partly prevented this. There was no significant change between the KO and WT mice in the number of microglia and astrocytes in the subcortical white matter after irradiation. Transcriptome analysis showed that the GO mitochondrial gene expression pathway was significantly enriched in the differentially expressed genes between the KO and WT group after irradiation. Compared with WT mice, expression of the mitochondrial fusion protein OPA1 and phosphorylation of the mitochondrial fission protein DRP1 (P-DRP1) were dramatically decreased in KO mice under physiological conditions. The protein levels of OPA1and P-DRP1 showed no differences in WT mice between the non-irradiated group and the irradiated group but had remarkably increased levels in the KO mice after irradiation. These results indicate that inhibition of autophagy reduces irradiation-induced subcortical white matter injury not by reducing inflammation, but by increasing mitochondrial fusion and inhibiting mitochondrial fission.
Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora
Authors: Pellegrini Pasquale , Hervera Arnau , Varea Olga , Brewer M. Kathryn , López-Soldado Iliana , Guitart Anna , Aguilera Mònica , Prats Neus , del Río José Antonio , Guinovart Joan J. , Duran Jordi 
Published: December 2021

AbstractLafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates—the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs in the brain underlies the neurological phenotype of the disease. LBs are composed of abnormal glycogen and various associated proteins, including p62, an autophagy adaptor that participates in the aggregation and clearance of misfolded proteins. To study the role of p62 in the formation of LBs and its participation in the pathology of LD, we generated a mouse model of the disease (malinKO) lacking p62. Deletion of p62 prevented LB accumulation in skeletal muscle and cardiac tissue. In the brain, the absence of p62 altered LB morphology and increased susceptibility to epilepsy. These results demonstrate that p62 participates in the formation of LBs and suggest that the sequestration of abnormal glycogen into LBs is a protective mechanism through which it reduces the deleterious consequences of its accumulation in the brain.
Four Puzzles of Reputation-Based Cooperation
Authors: Giardini Francesca , Balliet Daniel , Power Eleanor A. , Számadó Szabolcs , Takács Károly 
Published: December 2021

AbstractResearch in various disciplines has highlighted that humans are uniquely able to solve the problem of cooperation through the informal mechanisms of reputation and gossip. Reputation coordinates the evaluative judgments of individuals about one another. Direct observation of actions and communication are the essential routes that are used to establish and update reputations. In large groups, where opportunities for direct observation are limited, gossip becomes an important channel to share individual perceptions and evaluations of others that can be used to condition cooperative action. Although reputation and gossip might consequently support large-scale human cooperation, four puzzles need to be resolved to understand the operation of reputation-based mechanisms. First, we need empirical evidence of the processes and content that form reputations and how this may vary cross-culturally. Second, we lack an understanding of how reputation is determined from the muddle of imperfect, biased inputs people receive. Third, coordination between individuals is only possible if reputation sharing and signaling is to a large extent reliable and valid. Communication, however, is not necessarily honest and reliable, so theoretical and empirical work is needed to understand how gossip and reputation can effectively promote cooperation despite the circulation of dishonest gossip. Fourth, reputation is not constructed in a social vacuum; hence we need a better understanding of the way in which the structure of interactions affects the efficiency of gossip for establishing reputations and fostering cooperation.
Exploring Causal Relationships for Geoheritage Interpretation — Variable Effects of Cenozoic Volcanism in Central European Sedimentary Tablelands
Authors: Migoń Piotr , Pijet-Migoń Edyta 
Published: December 2021

AbstractModern conceptual approach to geointerpretation and geoeducation emphasizes the holistic understanding of the environment and attends to linkages between various abiotic, biotic, and cultural components. In this paper, we highlight multiple relationships between Cenozoic volcanism and host sedimentary rocks, mainly sandstones of Cretaceous age, which can be explored in the context of geotourism and geoeducation in several Central European geoparks (Bohemian Paradise UNESCO Global Geopark, Land of Extinct Volcanoes Aspiring Geopark, Ralsko National Geopark) and their surroundings. These include the effects of magmatism on sandstones, with further consequences for landform development at different spatial scales, the origin of mineral resources, underpinning of biological diversity, and specific land use contrasts. Existing interpretation provisions are reviewed, and a three-tiered framework to show these different linkages is proposed. It is argued that different, but complementary themes can be addressed at the landscape, landform, and individual outcrop (geosite) level.
Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling
Authors: Bernhard Sara Vanessa , Seget-Trzensiok Katarzyna , Kuffer Christian , Krastev Dragomir B. , Stautmeister Lisa-Marie , Theis Mirko , Keuper Kristina , Boekenkamp Jan-Eric , Kschischo Maik , Buchholz Frank , Storchova Zuzana 
Published: December 2021

Abstract

Background
Whole genome doubling is a frequent event during cancer evolution and shapes the cancer genome due to the occurrence of chromosomal instability. Yet, erroneously arising human tetraploid cells usually do not proliferate due to p53 activation that leads to CDKN1A expression, cell cycle arrest, senescence and/or apoptosis.

Methods
To uncover the barriers that block the proliferation of tetraploids, we performed a RNAi mediated genome-wide screen in a human colorectal cancer cell line (HCT116).

Results
We identified 140 genes whose depletion improved the survival of tetraploid cells and characterized in depth two of them: SPINT2 and USP28. We found that SPINT2 is a general regulator of CDKN1A transcription via histone acetylation. Using mass spectrometry and immunoprecipitation, we found that USP28 interacts with NuMA1 and affects centrosome clustering. Tetraploid cells accumulate DNA damage and loss of USP28 reduces checkpoint activation, thus facilitating their proliferation.

Conclusions
Our results indicate three aspects that contribute to the survival of tetraploid cells: (i) increased mitogenic signaling and reduced expression of cell cycle inhibitors, (ii) the ability to establish functional bipolar spindles and (iii) reduced DNA damage signaling.