bluuebunny/crossref_metadata_2025_split huggingface dataset:
The level of creativity of teachers to overcome the limitations of infrastructure in the learning process of physical education sports and health in Junior High School in Matesih District Karanganyar Regency
Authors: H. Angga Novianto , Waluyo Waluyo , Hendarto Singgih 
Published: June 2021

The purpose of this research is to find out the level of creativity of teachers to overcome the limitations of infrastructure in the learning process of Physical Education, Sports and Health in junior high schools in Matesih Subdistrict, Karanganyar Regency. This research is descriptive research. Deskrptif research is research conducted to find out the value of independent variables, either one or more variables without making comparisons, or connecting with other variables that are researched and analyzed so as to produce conclusions. The subject of this study was pjok teachers from Matesih sub-district, Karanganyar regency with 10 people. Data collection techniques are by statement questionnaires. Data analysis using descriptive statistics. The results showed that the level of creativity of teachers to overcome the limitations of infrastructure in the learning process of Physical Education, Sports and Health in junior high schools in Matesih Subdistrict, Karanganyar Regency, for the category of "very high" as many as 2 teachers Penjasorkes or by 20%, category "high" as much as 1 teacher Penjasorkes or by 10%, category "medium" as much as 3 teachers Penjasorkes or by 30%, category "low" as many as 4 teachers Penjasorkes or as much as 4% , and the category "very low" as much as 0 teachers Penjasorkes or by 0%.
Proteomic characterisation of serum proteins from Atlantic salmon (Salmo salar L.) from an outbreak with Cardiomyopathy Syndrome
Authors: Costa Janina , Thompson Kim , Pozo Jorge del , McLean Kevin , Inglis Neil , Sourd Philippe , Bordeianu Andrei 
Published: June 2021

Abstract
Cardiomyopathy syndrome (CMS), caused by piscine myocarditis virus (PMCV), is a serious challenge to Atlantic salmon (Salmo salar L.) aquaculture. Regrettably, husbandry techniques are the only tool to manage CMS outbreaks, and no prophylactic measures are available at present. Early diagnosis of CMS is therefore desirable, preferably with non-lethal diagnostic methods, such as serum biomarkers. To identify candidate biomarkers for CMS, the protein content of pools of sera (4 fish/pool) from salmon a CMS outbreak (3 pools) and from clinically healthy salmon (3 pools) were compared using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). Overall, seven proteins were uniquely identified in the sera of clinically healthy fish, while twenty seven proteins were unique to the sera of CMS fish. Of the latter, 24 have been associated with cardiac disease in humans. These were grouped as leakage enzymes (creatine kinase, lactate dehydrogenase, glycogen phosphorylase and carbonic anhydrase); host reaction proteins (acute phase response proteins - haptoglobin, fibrinogen, α2-macroglobulin, ceruloplasmin; and complement-related proteins); and regeneration/remodelling proteins (fibronectin, lumican and retinol). Clinical evaluation of the suitability of these proteins as biomarkers of CMS, either individually or as part of a panel, is a logical next step for the development of early diagnostic tools for CMS.
Nonlinear vibration response of a complex aeroengine under the rubbing fault
Authors: Liu Jingze , Fei Qingguo , Wu Shaoqing , Tang Zhenhuan , Zhang Dahai 
Published: June 2021

Abstract
Rolling bearing and squeeze film damper will introduce structural nonlinearity into the dynamic model of aeroengine. Rubbing will occur due to the clearance reduction design of the engine. The coupling of structural nonlinearity and fault nonlinearity will make the engine present rich vibration responses. This paper aims to analyze the nonlinear vibration behavior of the whole aeroengine including rolling bearing and squeeze film damper under rubbing fault. Firstly, the dynamic model of a turboshaft engine with nonlinear support and rubbing fault is established; The rolling bearing force, the oil film force and the rubbing force are introduced into a dual-rotor-casing model with six support points. Secondly, the linear part of the model is verified by the dynamic characteristics of the three-dimensional finite element model. Finally, the varying compliance vibration, the damping effect and the bifurcation mechanism are analyzed in detail in which the bearing clearance, speed ratio and rubbing stiffness are considered. Results show that the rubbing fault in the nonlinear support case will excite more significant varying compliance vibration in the low-speed region and expand the rotating speed range of the chaotic region in the high-speed region compared with that in the linear support case.
Using a Discrete Choice Experiment to Examine the Factors Influencing Clinical Trial Participation in a Nationally Representative Sample
Authors: Queally Michelle , Devane Declan , Griffin Matthew D. , Gillespie Paddy , Pandit Abhay 
Published: June 2021

Abstract
IntroductionUnderstanding the key factors that inform an individual’s decision-making process for participating in a clinical trial (CT) can improve the efficiency of recruitment for CT studies. Currently, little is known, in quantitative terms, about the relative importance of the different factors that influence CT participation decisions.ObjectiveThe objectives of this study were to design and conduct a discrete choice experiment (DCE) to identify critical factors, or attributes, that influence CT participation, and to estimate public preferences for, and trade-offs between, different levels of these attributes.MethodsA DCE was designed, with input from a public patient involvement (PPI) panel and conducted via an online survey of 525 nationally representative Irish citizens. The attributes identified and included in the DCE to inform CT participation included: (1) communication, (2) financial incentive, (3) likelihood of benefit, (4) risk of side effects, and (5) follow up period. All respondents were presented with a set of choice cards and asked to choose between participating in one of two CTs, differentiated by their attributes levels, or opt-out. A series of econometric statistical regression models were estimated to generate the results of interest.ResultsRespondents had preferences which, in order of relative importance, had a lower risk of side effects, a higher likelihood of benefit, a shorter follow up, information communicated by the respondent’s doctor or nurse, and a financial incentive for participation.ConclusionTo the best of our knowledge, this is the first study to utilise a DCE to estimate preferences of the public regarding factors influencing CT participation. These findings may be useful for future CT design as they enable researchers to elicit how individuals may weigh up their choices and consider trade-offs between factors that affect their decision to participate. This study was also the first DCE to include a PPI panel to help inform the DCE design and development.
Awareness of Aerosol related transmission of COVID-19 among the Dentists of Nepal
Authors: Pandey Nashib , Basnet Buddha , Koju Sushmit , Khapung Anju , Gupta Alka 
Published: June 2021

Abstract
Objective: To access the awareness of dental practitioners of Nepal towards COVID-19 transmission through aerosols.Materials and Methods: The study involved 384 dentists from all over Nepal and was conducted for a period of three months. A self-reported online questionnaire was developed using Google forms and the link was shared. It emphasized the awareness related to the aerosol and ventilation system in their daily practices was prepared. The data were analysed in Statistical Package for Social Sciences version 20.0 software. Results: Majority of participants were female 52.9% (n = 203) and within the age groups of <30 years 57% (n = 219). Participants from Bagmati Province were 60.4% (n = 232), with least from Sudurpaschim Province 0.5% (n = 2). 60% of participants provided only emergency services during the COVID-19 pandemic and few (7%) provided consultations via telephone. The current ventilation system used was a well-ventilated room with open windows 65.4% (n = 251). However, 52.8% (n = 203) preferred specialized operatory incorporating high efficiency particulate air (HEPA) filters and ultraviolet (UV) light. More than 60% of respondents were unaware of the particle size of the aerosol.Conclusions: The obtained results signify the need for the proper ventilation system with appropriate air filtration systems in dental clinical setups.
A Strengthening Mechanism and Influencing Factors of Coal Fly Ash using Microbial-Induced Carbonate Precipitation
Authors: Wu Shuaifeng , Cai Hong , Wei Ran , Xiao Jianzhang , Yan Jun , Wang Ziwen 
Published: June 2021

Abstract
Coal fly ash (CFA) that is discharged from coal-fired power plants has characteristics of fine particles, a small specific gravity and a large pore ratio. The dust suppression and strengthening of CFA is usually carried out by spraying water in the ash storage yard, but this practical approach is unsatisfactory. The strength of the CFA filling material affects the construction safety and operational safety of the ash dams. To carry out effective CFA material utilization and dust-pollution control, this paper applied the microbial-induced carbonate precipitation (MICP) method to enhance the strength of CFA under two curing conditions of natural evaporation (NE) and in a moisture cylinder (MC). The microbial-reaction mechanism, strengthening characteristics and influencing factors were studied. The results show that: 1) the calcium carbonate that is produced by microorganisms in the CFA is calcite, and the calcium-carbonate content increases from 7% to 18.9% and 15.3% under the MC and NE curing conditions, respectively; 2) MICP can improve the CFA strength, and the unconfined compressive strength can be increased by 6.55 times to 97.63 kPa under the MC curing conditions; 3) the solidification strength of CFA varies significantly with the concentration of CaCl2.2H2O and CH4N2O nutrients. The peak stress increases initially and then decreases with an increase in nutrient salt concentration. The optimum nutrient concentration was 0.5 mol/L and 1.0 mol/L for the MC and NE curing conditions, respectively; 4) calcium carbonate that was induced by microbial reaction can reduce the water loss in the ash specimen, and allow the ash surface to form a better water-retention effect, with good prospects for dust suppression.
Fine Structure Constant derived from Principle Theory.
Authors: Geilhaupt Manfred 
Published: June 2021

Abstract
Derivation of mass (m), charge (e) and fine structure constant (FSC) from theory are unsolved problems in physics up to now. Neither the Standard Model (SM) nor the General theory of Relativity (GR) has provided a complete explanation for mass, charge and FSC. The question “of what is rest mass” is therefore still essentially unanswered. We will show that the combination of two Principle Theories, General Relativity and Thermodynamics (TD), is able to derive the restmass of an electron (m) which surprisingly depends on the (Sommerfeld) FSC (same for the charge (e)).
Ground Surface Settlement Evaluation by Proportional Hazards Model in Tunneling Projects
Authors: Osalou Ali Kazempour , moosazadeh sayfoddin , Qarahasanlou Ali Nouri 
Published: June 2021

Abstract
Nowadays, tunnel excavation plays a major role in development of countries. Due to the complex and challenging ground conditions, a comprehensive study and analysis must be done before, during and also after the excavation of tunnels. Hence, the importance of study and evaluation of ground settlement are dramatically increased, since many tunnel projects are performed in the urban areas where there are plenty of constructions, buildings and facilities. For this reason, the control and prediction of ground settlement is one of the complicated topic in the fields of risk engineering. Therefore, in this paper, proportional hazard model (PHM) is used to analyze and study the ground settlement induced by Tabriz Metro Line 2 (TML2) tunneling. The PHM method is a semi-parametric regression method that can enter environmental conditions or factors affecting settlement probability. These influential factors are used as risk factors in the analysis. After establishing a database for a case study and using proportional hazard model for surface settlement analysis, and then, by evaluating the effect of environmental conditions on the ground surface settlement, it has been found that the risk factors of grouting pressure behind the segment, the ratio of tunnel depth to groundwater level, and drained cohesion strength at a significant level of 5% have a direct effect on the probability of settlement. The results also showed that the effect of grout injection pressure on ground subsidence is more than other parameters, and with increasing injection pressure, the probability of exceeding safe subsidence values decreases. In addition, it has been found that increasing the risk factor for the ratio of tunnel depth to groundwater level reduces the probability of exceeding the safe ground settlement. Finally, increasing the number of risk factors for drained cohesion strength increases the probability of exceeding safe settlement.
Financial distress and its associated burden in couples coping with an advanced cancer
Authors: Kroll Juliet , Kim Seokhun , Cho Dalnim , Weathers Shiao-Pei , Chen Aileen , Smith Grace , Bruera Eduardo , Milbury Kathrin 
Published: June 2021

Abstract
Purpose
As the economic burden and financial distress (FD) resulting from cancer care are increasingly recognized, FD remains inadequately understood from the perspective of patients and their spousal caregiver, the relational context where most financial and treatment decisions are navigated. Therefore, we assessed FD in both patients with advanced cancer and their spouses to identify symptom and QOL correlates. We additionally examined if illness communication moderated the association between FD and QOL.
Methods
Patients undergoing treatment for stage III/IV lung cancer or grade III/IV primary brain tumor and their spouses completed measures of their own FD, QOL, symptoms, perception of their spouse’s symptoms, and overall illness communication.
Results
Patients (62.7%) and spouses (64.7%) endorsed FD; however, spouses rated FD with greater relative severity. For both, FD was associated with greater anxiety, depression, and poorer physical QOL. For patients, FD was additionally associated with poorer mental QOL. Spousal caregivers accurately perceived patient FD, yet patients underreported spouse’s FD by a clinically meaningful difference. A 3-way interaction (FD X role X illness communication) revealed (b = .40, p = .041) that illness communication moderated the association between FD and physical QOL for spouses only.
Conclusion
In the advanced cancer setting, FD is prevalent in both patients and their caregivers and associated with psychological distress and poor physical QOL. Results suggest that optimal FD interventions should include patients and spouses. As illness communication appears to buffer the negative association of FD with physical QOL, studies targeting illness communication deficits in couples facing advanced disease are warranted.
Time-Dependent Effect Of Anthracycline-Based Chemotherapy On Central Arterial Stiffness: A Systematic Review And Meta-Analysis
Authors: Schneider Caroline , González-Jaramillo Nathalia , Marcin Thimo , Campbell Kristin L. , Suter Thomas , Bano Arjola , Wilhelm Matthias , Eser Prisca 
Published: June 2021

Abstract
Background and AimsAnthracycline-based chemotherapy (Anth-bc) has been proposed to increase arterial stiffness, however, the time-dependency of these effects remain unclear. This systematic review and meta-analysis aimed to investigate the time-dependent effect of Anth-bc on markers of central aortic stiffness, namely aortic distensibility (AD) and pulse-wave-velocity (PWV) in cancer patients.Methods An extensive literature search without language restrictions was performed to identify all studies presenting longitudinal data on the effect of Anth-bc on either AD and/or central PWV in cancer patients of all ages. An inverse-variance weighted random-effect model was performed with differences from before to after chemotherapy, as well as for short vs. mid-term effects. ResultsOf 1811 articles identified, 6 observational studies with a total of 282 patients (median age 51±11; 70% women) were included, of which four studies measured AD and five PWV. Short-term (3-4 months), there was a clinically meaningful increase in arterial stiffness, namely an increase in PWV of 4.21 m/s (95%CI -0.19; 8.61) and a decrease in AD of -1.49 mmHg-1 (-3.25; 0.27) but a much smaller effect was observed mid-term (6-12 months) for PWV of 1.05 m/s (-1.45; 3.55) and AD of -0.37 mmHg-1 (-1.13; 0.39). There was considerable heterogeneity among the studies.ConclusionsResults from this analysis suggest that in the short-term, Anth-bc increases arterial stiffness, but that these changes may partly be reversible after therapy termination. Future studies need to elucidate the long-term consequences of Anth-bc on arterial stiffness, by performing repeated follow-up measurements after Anth-bc termination.
ALS-Causing Protein TDP-43 Impairs SREBP2 Cholesterol Regulation
Authors: Egawa Naohiro , Izumi Yuishin , Tsuge Itaru , Fujita Koji , Shimano Hitoshi , Izumikawa Keiichi , Takahashi Nobuhiro , Tsukita Kayoko , Enami Takako , Nakamura Masahiro , Watanabe Akira , Naitoh Motoko , Suzuki Shigehiko , Seki Tsuneyoshi , Kobayashi Kazuhiro , Toda Tatsushi , Kaji Ryuji , Takahashi Ryosuke , Inoue Haruhisa 
Published: June 2021

Abstract
Dyslipidemia is correlated with the prognosis of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein (TDP-43) inclusions. We investigated molecular mechanisms of lipid metabolism regulated by TDP-43 in ALS. Expression microarray and RNA deep sequencing (RNA-Seq) were performed using cell lines expressing doxycycline-inductive TDP-43. Gene expression and transcriptome profiling identified 434 significantly altered genes under high levels of TDP-43 (Tukey’s test, P < 0.05) including sterol regulatory element-binding protein 2 (SREBP2), a master regulator of cholesterol homeostasis and its downstream genes. TDP-43 overexpression impaired SREBP2 transcriptional activity, leading to inhibition of cholesterol biosynthesis via the nutrient- and growth factor-responsive kinase mTOR Complex I (mTORC1). The amount of cholesterol was significantly decreased in motor neuronal cultures derived from ALS-patient induced pluripotent stem cells (iPSCs) as well as in the spinal fluids of ALS patients and in the spinal cord of ALS model mice. Impairment of cholesterol synthesis is caused by an increase in toxic function of TDP-43 in ALS.
Fibrosis-Net: A Tailored Deep Convolutional Neural Network Design For Prediction of Pulmonary Fibrosis Progression From Chest CT Images
Authors: Wong Alexander , Lu Jack , Dorfman Adam , McInnis Paul , Famouri Mahmoud , Manary Daniel , Lee James Ren Hou , Lynch Michael 
Published: June 2021

Abstract
Background: Pulmonary fibrosis is a devastating chronic lung disease that causes irreparable lung tissue scarring and damage, resulting in progressive loss in lung capacity and has no known cure. A critical step in the treatment and management of pulmonary fibrosis is the assessment of lung function decline, with computed tomography (CT) imaging being a particularly effective method for determining the extent of lung damage caused by pulmonary fibrosis. Motivated by this, we introduce Fibrosis-Net, a deep convolutional neural network design tailored for the prediction of pulmonary fibrosis progression from chest CT images. More specifically, machine-driven design exploration was leveraged to determine a strong architectural design for CT lung analysis, upon which we build a customized network design tailored for predicting forced vital capacity (FVC) based on a patient's CT scan, initial spirometry measurement, and clinical metadata. Finally, we leverage an explainability-driven performance validation strategy to study the decision-making behaviour of Fibrosis-Net as to verify that predictions are based on relevant visual indicators in CT images.Results: Experiments using a patient cohort from the OSIC Pulmonary Fibrosis Progression Challenge showed that the proposed Fibrosis-Net is able to achieve a significantly higher modified Laplace Log Likelihood score than the winning solutions on the challenge. Furthermore, explainability-driven performance validation demonstrated that the proposed Fibrosis-Net exhibits correct decision-making behaviour by leveraging clinically-relevant visual indicators in CT images when making predictions on pulmonary fibrosis progress. Conclusion: Fibrosis-Net is able to achieve a significantly higher modified Laplace Log Likelihood score than the winning solutions on the OSIC Pulmonary Fibrosis Progression Challenge, and has been shown to exhibit correct decision-making behaviour when making predictions. Fibrosis-Net is available to the general public in an open-source and open access manner as part of the OpenMedAI initiative. While Fibrosis-Net is not yet a production-ready clinical assessment solution, we hope that its release will encourage researchers, clinicians, and citizen data scientists alike to leverage and build upon it.
Histopatholgy and Clinical Implication of Treatment-Related Changes After Gamma Knife Radiosurgery in Patients With Brain Metastases
Authors: Kim Jeong-Hwa , Choi Jung-Won , Kong Doo-Sik , Seol Ho-Jun , Nam Do-Hyun , Suh Yeon-Lim , Lee Jung-Il , Ryu Jae-Wook , Kim Sung-Tae 
Published: June 2021

Abstract
A late-onset treatment-related changes (TRCs), which represent radiographic radiation necrosis (RN), frequently occur after stereotactic radiosurgery (SRS) for brain metastases and often need surgical treatment. This study aimed to validate the true pathology and investigate clinical implication of surgically resected TRCs on advanced magnetic resonance imaging (MRI).Retrospective analyses of 86 patients who underwent surgical resection after radiosurgery of brain metastases were performed. Fifty-four patients displayed TRCs on preoperative MRI, comprising pure RN in 19 patients (TRC-RN group) and mixed viable tumor cells in 35 patients (TRC-PD group). Thirty-two patients revealed the consistent diagnosis of progressive disease in both MRI and histopathology (PD-PD group). The TRC-PD group showed larger prescription isodose volume (9.4 cm3) than the TRC-RN (4.06 cm3, p=0.014) group and a shorter time interval from SRS to preoperative MRI diagnosis (median 4.07 months) than the PD-PD group (median 8.77 months, p=0.004). Progression-free survival was significantly different among the three groups (p<0.001), but not between TRC-RN and TRC-PD (post hoc test, p=1.00), while no difference was observed in overall survival (p=0.067).Brain metastases featured as TRCs after SRS frequently contained viable tumor cells. However, this histologic heterogeneity had a minor impact on benign prognosis of TRCs after surgical resection.