bluuebunny/crossref_metadata_2025_split huggingface dataset:
LSD, madness and healing: Mystical experiences as possible link between psychosis model and therapy model
Authors: Wießner Isabel , Falchi Marcelo , Palhano-Fontes Fernanda , Feilding Amanda , Ribeiro Sidarta , Tófoli Luís Fernando 
Published: July 2021

AbstractBackgroundFor a century, psychedelics have been investigated as models of psychosis for demonstrating phenomenological similarities with psychotic experiences and as therapeutic models for treating depression, anxiety, and substance use disorders. This study sought to explore this paradoxical relationship connecting key parameters of the psychotic experience, psychotherapy, and psychedelic experience.MethodsIn a randomized, double-blind, placebo-controlled, crossover design, 24 healthy volunteers received 50 μg d-lysergic acid diethylamide (LSD) or inactive placebo. Psychotic experience was assessed by aberrant salience (Aberrant Salience Inventory, ASI), therapeutic potential by suggestibility (Creative Imagination Scale, CIS) and mindfulness (Five Facet Mindfulness Questionnaire, FFMQ; Mindful Attention Awareness Scale, MAAS; Experiences Questionnaire, EQ), and psychedelic experience by four questionnaires (Altered State of Consciousness Questionnaire, ASC; Mystical Experiences Questionnaire, MEQ; Challenging Experiences Questionnaire, CEQ; Ego-Dissolution Inventory, EDI). Relationships between LSD-induced effects were examined.ResultsLSD induced psychedelic experiences, including alteration of consciousness, mystical experiences, ego-dissolution, and mildly challenging experiences, increased aberrant salience and suggestibility, but not mindfulness. LSD-induced aberrant salience correlated highly with complex imagery, mystical experiences, and ego-dissolution. LSD-induced suggestibility correlated with no other effects. Individual mindfulness changes correlated with aspects of aberrant salience and psychedelic experience.ConclusionsThe LSD state resembles a psychotic experience and offers a tool for healing. The link between psychosis model and therapeutic model seems to lie in mystical experiences. The results point to the importance of meaning attribution for the LSD psychosis model and indicate that psychedelic-assisted therapy might benefit from therapeutic suggestions fostering mystical experiences.
Interface Delay
Authors: GRINSTEAD John 
Published: July 2021

AbstractInterface Delay is a theory of syntactic development, which attempts to explain an array of constructions that are slow to develop, which are characterized by being sensitive to discourse-pragmatic considerations of the type associated with the natural semantic class of definites. The theory claims that neither syntax itself, nor the discourse-pragmatic abilities related to executive function and theory of mind themselves are slow to develop. Rather, the claim is that the nexus or interface between the two cognitive domains is slow to develop. We review the development of subjects in child Spanish as an example of this delayed growth trajectory. Further, we review evidence that a delay in the development of tense causes concomitant delays in the seemingly unrelated phenomena of non-nominative case subject pronoun use and un-inverted wh- questions.
Aspirin and omega-3 polyunsaturated fatty acid use and their interaction in cardiovascular diseases and colorectal adenomas
Authors: Wang Ivan E. , Yi Shana , Block Robert C. , Mousa Shaker A. 
Published: July 2021

AbstractAspirin (acetylsalicylic acid, ASA) is inexpensive and is established in preventing cardiovascular disease (CVD) and colorectal adenomas. Omega-3 (n3) polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have also shown benefit in preventing CVD. The combination could be an effective preventative measure in patients with such diseases. ASA and n3 PUFA reduced the risk of CVD in ASA-resistant or diabetic patients. EPA- and DHA-deficient patients also benefited the most from n3 PUFA supplementation. Synergistic effects between ASA and EPA and DHA are ‘V-shaped’ such that optimal ASA efficacy is dependent on EPA and DHA concentrations in blood. In colorectal adenomas, ASA (300 mg/d) and EPA reduced adenoma burden in a location- and subtype-specific manner. Low doses of ASA (75–100 mg/d) were used in CVD prevention; however, ultra-low doses (30 mg/d) can also reduce thrombosis. EPA-to-DHA ratio is also important with regard to efficacy. DHA is more effective in reducing blood pressure and modulating systemic inflammation; however, high-dose EPA can lower CVD events in high-risk individuals. Although current literature has yet to examine ASA and DHA in preventing CVD, such combination warrants further investigation. To increase adherence to ASA and n3 PUFA supplementation, combination dosage form may be required to improve outcomes.
Pediatric Prehospital Advanced Airway Management by Anesthesiologist and Nurse Anesthetist Staffed Critical Care Teams
Authors: Renberg Mattias , Hertzberg Daniel , Kornhall Daniel , Günther Mattias , Gellerfors Mikael 
Published: July 2021

AbstractIntroduction:Prehospital pediatric tracheal intubation (TI) is a possible life-saving intervention that requires adequate experience to mitigate associated complications. The pediatric airway and respiratory physiology present challenges in addition to a relatively rare incidence of prehospital pediatric TI.Study Objective:The aim of this study was to describe characteristics and outcomes of prehospital TI in pediatric patients treated by critical care teams.Methods:This is a sub-group analysis of all pediatric (<16 years old) patients from a prospective, observational, multi-center study on prehospital advanced airway management in the Nordic countries from May 2015 through November 2016. The TIs were performed by anesthesiologists and nurse anesthetists staffing six helicopter and six Rapid Response Car (RRC) prehospital critical care teams.Results:In the study, 74 children were tracheal intubated, which corresponds to 3.7% (74/2,027) of the total number of patients. The pediatric patients were intubated by very experienced providers, of which 80% had performed ≥2,500 TIs. The overall TI success rate, first pass success rate, and airway complication rate were in all children (<16 years) 98%, 82%, and 12%. The corresponding rates among infants (<2 years) were 94%, 67%, and 11%. The median time on scene was 30 minutes.Conclusion:This study observed a high overall prehospital TI success rate in children with relatively few associated complications and short time on scene, despite the challenges presented by the pediatric prehospital TI.
‘How We Were Never Posthuman’: Technologies of the Embodied Voice in Pamela Z'sVoci
Authors: BARRETT G. DOUGLAS 
Published: July 2021

AbstractThis article analyses composer Pamela Z's work in light of critiques of posthumanism from Black studies and sound/music studies. Z's large-scale multimedia workVoci(2003), which the artist describes as a ‘polyphonic mono-opera’, consists of a series of eighteen scenes that combine vocal performance with digital video and audio processing. Z manipulates these sources using the BodySynth, an alternate controller interface that converts bodily gestures into expressive control signals. Z's work has been considered through cyborgian, Afrofuturist, and posthumanist discourses. But rather than affirm her practice as fully consonant with technological visions of the posthuman, I argue that she challenges the very liberal humanism upon which the posthuman is built. For a key tenet of liberal humanism, as Alexander G. Weheliye observes, was the racial and gendered apportionment of humanity into full humans, not-quite-humans, and non-humans. We have never been completely human, he suggests, let alone posthuman.Z uses technologies of the embodied voice to confront both the posthuman imaginary and the continued effects of its ideological preconditions in racio-colonial liberal humanism. In aVociscene entitled ‘Voice Studies’, for instance, Z engages the problem of ‘linguistic profiling’ as it applies to housing discrimination, citing the work of Stanford linguistics researcher John Baugh. Against a backdrop of percussive vocalizations, Z explains, ‘Studies reveal that people can often infer the race of an individual based on the sound of their voice’, subsequently playing back recordings of housing applicants containing vocal signifiers of racial difference. The article then contrasts this kind of ‘aural dimension of race’ found in Jennifer Lynn Stoever's notion of the ‘sonic color line’ with Pierre Schaeffer's attempt to separate sound from the social – as well as from bodies and identities – in his practice of acousmatic reduction. With this in mind, I show how Z construes the voice as an acous(ma)tic technology of embodiment while reframing opera's humanist legacy throughVoci's allegorical narration of the ‘prehuman’, ‘human’, and ‘posthuman’. Moving with and against a posthuman imaginary, Z suggests that although we have never quite been human or posthuman, we may nevertheless narrate new versions of each.
An Integrative Model for Soil Biogeochemistry and Methane Processes: I. Model Structure and Sensitivity Analysis
Authors: Ricciuto Daniel M. , Xu Xiaofeng , Shi Xiaoying , Wang Yihui , Song Xia , Schadt Christopher W. , Griffiths Natalie A. , Mao Jiafu , Warren Jeffrey M. , Thornton Peter E. , Chanton Jeff , Keller Jason K. , Bridgham Scott D. , Gutknecht Jessica , Sebestyen Stephen D. , Finzi Adrien , Kolka Randall , Hanson Paul J. 
Published: July 2021

AbstractEnvironmental changes are anticipated to generate substantial impacts on carbon cycling in peatlands, affecting terrestrial‐climate feedbacks. Understanding how peatland methane (CH4) fluxes respond to these changing environments is critical for predicting the magnitude of feedbacks from peatlands to global climate change. To improve predictions of CH4 fluxes in response to changes such as elevated atmospheric CO2 concentrations and warming, it is essential for Earth system models to include increased realism to simulate CH4 processes in a more mechanistic way. To address this need, we incorporated a new microbial‐functional group‐based CH4 module into the Energy Exascale Earth System land model (ELM) and tested it with multiple observational data sets at an ombrotrophic peatland bog in northern Minnesota. The model is able to simulate observed land surface CH4 fluxes and fundamental mechanisms contributing to these throughout the soil profile. The model reproduced the observed vertical distributions of dissolved organic carbon and acetate concentrations. The seasonality of acetoclastic and hydrogenotrophic methanogenesis—two key processes for CH4 production—and CH4 concentration along the soil profile were accurately simulated. Meanwhile, the model estimated that plant‐mediated transport, diffusion, and ebullition contributed to ∼23.5%, 15.0%, and 61.5% of CH4 transport, respectively. A parameter sensitivity analysis showed that CH4 substrate and CH4 production were the most critical mechanisms regulating temporal patterns of surface CH4 fluxes both under ambient conditions and warming treatments. This knowledge will be used to improve Earth system model predictions of these high‐carbon ecosystems from plot to regional scales.
Continental and Ecoregion‐Specific Drivers of Atmospheric NO2 and NH3 Seasonality Over Africa Revealed by Satellite Observations
Authors: Hickman Jonathan E. , Andela Niels , Tsigaridis Kostas , Galy‐Lacaux Corinne , Ossohou Money , Dammers Enrico , Van Damme Martin , Clarisse Lieven , Bauer Susanne E. 
Published: July 2021

AbstractAmmonia (NH3) and nitrogen oxides (NOx: nitrogen dioxide [NO2] + nitric oxide [NO]) play important roles in atmospheric chemistry. Throughout most of Africa, emissions of these gases are predominantly from soils and biomass burning. Here we use observations of tropospheric NO2 vertical column densities (VCDs) from the Ozone Monitoring Instrument from 2005 through 2017 and atmospheric NH3 VCDs from the Infrared Atmospheric Sounding Interferometer from 2008 through 2017 to evaluate seasonal variation of NO2 and NH3 VCDs across Africa and in seven African ecoregions. In regions where mean annual precipitation (MAP) is under 500 mm yr−1, we find that NO2 and NH3 VCDs are positively related to monthly precipitation, and where MAP is between 500 and 1,750 mm yr−1 or higher, NO2 VCDs are negatively related to monthly precipitation. In dry ecoregions, temperature and precipitation were important predictors of NH3 and NO2 VCDs, likely related to variation in soil emissions. In mesic ecoregions, monthly NO2 VCDs were strongly related to burned area, suggesting that biomass burning drives seasonality. NH3 VCDs in mesic ecoregions were positively related to both monthly temperature and monthly carbon monoxide (CO) VCDs, suggesting that a mixture of soil and biomass burning emissions influenced NH3 seasonality. In northern mesic ecoregions, monthly temperature explained most of the variance in monthly NH3 VCDs, suggesting that soil sources, including animal excreta, determined NH3 seasonality. In southern mesic ecoregions, monthly CO VCDs explained more variation in NH3 VCDs than temperature, suggesting that biomass burning may have greater influence over NH3 seasonality.
Scaling Analysis of the China France Oceanography Satellite Along‐Track Wind and Wave Data
Authors: Gao Yang , Schmitt François G. , Hu Jianyu , Huang Yongxiang 
Published: July 2021

AbstractTurbulence or turbulence‐like phenomena are ubiquitous in nature, often showing a power‐law behavior of the fluctuations in either spatial or temporal domains. This power‐law behavior is due to interactions among different scales of motion, and to the absence of characteristic scale. In this work, we consider the multiscale dynamics of China France Oceanography SATellite (CFOSAT) data as atmospheric and oceanic quantities influenced by turbulence. Fourier power spectra were estimated for the data provided by the CFOSAT via the Wiener‐Khinchine theorem to extract multiscale information for both wind speed (WS) and significant wave height (Hs). The WS data were collected from December 18, 2018 to August 31, 2020, and the Hs data from July 29, 2019 to August 31, 2020. Fourier power spectra for both WS and Hs exhibit power‐law features in the ranges of 100–3,000 km with a scaling exponent varying from 5/3 to 3. The global distributions and seasonal variations of for both WS and Hs have also been considered. The results show that due to the energetic convective activities in the low‐latitude zones, the scaling exponents in these regions are closer to the value of 5/3. Concerning the seasonal variations, for most regions, the scaling exponents in winter are larger than those in summer for WS. The seasonal variations of in low‐latitudes are stronger than those in the mid‐latitudes. Our preliminary results enrich the fundamental knowledge of ocean surface processes and also provide a benchmark for either oceanic or atmospheric models.
Widespread Race and Class Disparities in Surface Urban Heat Extremes Across the United States
Authors: Benz Susanne Amelie , Burney Jennifer Anne 
Published: July 2021

AbstractHere we use remotely sensed land surface temperature measurements to explore the distribution of the United States’ urban heating burden, both at high resolution (within cities or counties) and at scale (across the whole contiguous United States). While a rich literature has documented neighborhood‐level disparities in urban heat exposures in individual cities, data constraints have precluded comparisons across locations. Here, drawing on urban temperature anomalies during extreme summer surface temperature events from all 1,056 US counties with more than 10 developed census tracts, we find that the poorest tracts (and those with lowest average education levels) within a county are significantly hotter than the richest (and more educated) neighborhoods for 76% of these counties (54% for education); we also find that neighborhoods with higher Black, Hispanic, and Asian population shares are hotter than the more White, non‐Hispanic areas in each county. This holds in counties with both large and small spreads in these population shares, and for 71% of all counties the significant racial urban heat disparities persist even when adjusting for income. Although individual locations have different histories that have contributed to race‐ and class‐based geographies, we find that the physical features of the urban environments driving these surface heat exposure gradients are fairly uniform across the country. Systematically, the disproportionate heat surface exposures faced by minority communities are due to more built‐up neighborhoods, less vegetation, and—to a lesser extent—higher population density.
Hazard Assessment for Typhoon‐Induced Coastal Flooding and Inundation in Shanghai, China
Authors: Yin Jie , Lin Ning , Yang Yuhan , Pringle William J. , Tan Jinkai , Westerink Joannes J. , Yu Dapeng 
Published: July 2021

AbstractThis paper describes an integrated climatological‐hydrodynamic method that couples probabilistic hurricane model, storm surge model, inundation model, coastal protection data, and sea level rise projections to estimate tropical cyclone‐induced coastal flood inundation hazard in a coastal megacity‐Shanghai, China. We identify three “worst‐case” scenarios (extracted from over 5,000 synthetic storms) that generate unprecedentedly high flood levels in Shanghai. Nevertheless, we find that the mainland Shanghai is relatively safe from coastal flooding under the current climate, thanks to its high‐standard seawall protection. However, the city is expected to be increasingly at risk due to future sea level rise, with inundation two times and 20 times more likely to occur by mid‐ and late‐21st century, respectively, and inundation depth and area to greatly increase (e.g., 60%–1,360% increase in the inundation area for the “worst cases” by 2,100). The low‐lying and poorly protected area (e.g., Chongming Island) is likely to be moderately affected by flood events with long return periods at the current state but could be largely inundated in future sea‐level‐rise situations.
Efficacy of an occluding toothpaste on dentinal hypersensitivity over 14 days
Authors: Creeth Jonathan E. , Goyal Chhaju , Qaqish Jimmy , Maclure Robert , Holt Jonathan S. 
Published: July 2021

Abstract
Objectives:
To evaluate a 0.454% stannous fluoride/5% sodium tripolyphosphate (STP) toothpaste’s ability to provide relief from dentinal hypersensitivity (DH) applied using ‘focused brushing.’

Materials and methods:
In two randomised, examiner-blind, parallel-group studies, a SnF2/STP toothpaste was applied by brushing two selected sensitive teeth before 1 min whole-mouth brushing, compared to 1 min whole-mouth brushing only, with a negative control toothpaste. DH was assessed via evaporative (air) (Schiff scale) and tactile (Yeaple probe) stimuli after 7 and 14 d of twice-daily brushing.

Results:
In total, 141 (Study 1)/142 (Study 2) participants were randomised. In Study 1, the test treatment significantly reduced DH at 7/14 d versus baseline (7/14 d Schiff difference: −0.74 [−0.84,−0.65]/−1.39 [−1.54,−1.23]; tactile: 6.00 [4.88,7.13]/15.30 [13.34,17.26]); whereas the Control treatment did not (7/14 d Schiff difference −0.03 [−0.13,0.06]/−0.10 [−0.25,0.06]; tactile: 0.77 [−0.36,1.90]/0.77 [−1.20,2.74]). Differences between Test and Control were statistically significant (p < 0.0001 all cases). In Study 2, both treatments reduced DH compared to baseline by both measures, but there were no significant between-treatment differences. Toothpastes were generally well-tolerated.

Discussion and conclusions:
Previous studies and Study 1 support SnF2/5% STP toothpaste efficacy; Study 2 results may have been influenced by placebo/Hawthorne effects. DH study design needs to, where possible, negate such effects.
In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease
Authors: Bose Sourav K. , White Brandon M. , Kashyap Meghana V. , Dave Apeksha , De Bie Felix R. , Li Haiying , Singh Kshitiz , Menon Pallavi , Wang Tiankun , Teerdhala Shiva , Swaminathan Vishal , Hartman Heather A. , Jayachandran Sowmya , Chandrasekaran Prashant , Musunuru Kiran , Jain Rajan , Frank David B. , Zoltick Philip , Peranteau William H. 
Published: July 2021

AbstractIn utero base editing has the potential to correct disease-causing mutations before the onset of pathology. Mucopolysaccharidosis type I (MPS-IH, Hurler syndrome) is a lysosomal storage disease (LSD) affecting multiple organs, often leading to early postnatal cardiopulmonary demise. We assessed in utero adeno-associated virus serotype 9 (AAV9) delivery of an adenine base editor (ABE) targeting the Idua G→A (W392X) mutation in the MPS-IH mouse, corresponding to the common IDUA G→A (W402X) mutation in MPS-IH patients. Here we show efficient long-term W392X correction in hepatocytes and cardiomyocytes and low-level editing in the brain. In utero editing was associated with improved survival and amelioration of metabolic, musculoskeletal, and cardiac disease. This proof-of-concept study demonstrates the possibility of efficiently performing therapeutic base editing in multiple organs before birth via a clinically relevant delivery mechanism, highlighting the potential of this approach for MPS-IH and other genetic diseases.
Data storage using peptide sequences
Authors: Ng Cheuk Chi A. , Tam Wai Man , Yin Haidi , Wu Qian , So Pui-Kin , Wong Melody Yee-Man , Lau Francis C. M. , Yao Zhong-Ping 
Published: July 2021

AbstractHumankind is generating digital data at an exponential rate. These data are typically stored using electronic, magnetic or optical devices, which require large physical spaces and cannot last for a very long time. Here we report the use of peptide sequences for data storage, which can be durable and of high storage density. With the selection of suitable constitutive amino acids, designs of address codes and error-correction schemes to protect the order and integrity of the stored data, optimization of the analytical protocol and development of a software to effectively recover peptide sequences from the tandem mass spectra, we demonstrated the feasibility of this method by successfully storing and retrieving a text file and the music file Silent Night with 40 and 511 18-mer peptides respectively. This method for the first time links data storage with the peptide synthesis industry and proteomics techniques, and is expected to stimulate the development of relevant fields.
Epigenetic memories and the evolution of infectious diseases
Authors: McLeod David V. , Wild Geoff , Úbeda Francisco 
Published: July 2021

AbstractGenes with identical DNA sequence may show differential expression because of epigenetic marks. Where epigenetic marks respond to past conditions, they represent a form of “memory”. Despite their medical relevance, the impact of memories on the evolution of infectious diseases has rarely been considered. Here we explore the evolution of virulence in pathogens that carry memories of the sex of their previous host. We show that this form of memory provides information about the sex of present and future hosts when the sexes differ in their pathogen’s transmission pattern. Memories of past hosts enable the evolution of greater virulence in infections originating from one sex and infections transmitted across sexes. Thus, our results account for patterns of virulence that have, to date, defied medical explanation. In particular, it has been observed that girls infected by boys (or boys infected by girls) are more likely to die from measles, chickenpox and polio than girls infected by girls (or boys infected by boys). We also evaluate epigenetic therapies that tamper with the memories of infecting pathogens. More broadly, our findings imply that pathogens can be selected to carry memories of past environments other than sex. This identifies new directions in personalised medicine.