bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors determining outcome of post-angiogram-negative subarachnoid hemorrhage
Authors: Kumar N , Gupta S 
Published: November 2021

Aim:
To determine the risk factors affecting outcome at the end of 90 days of post-angiogram-negative subarachnoid hemorrhage (SAH).

Methods:
Non-traumatic SAH cases were reviewed from the case records of patients who had reported to the Department of Neurology of a tertiary care hospital and 50 angio-negative SAH cases were included after excluding all the cases with known cause of hemorrhage after doing computed tomography angiography (CTA)/digital subtraction angiography (DSA). The presence of hypertension, diabetes mellitus, coronary artery disease (CAD), history of alcohol and smoking, and various scales like Hunt and Hess Scale (HHS), World Federation of Neurological Surgeons (WFNS), and Fisher scale had been recorded at admission. The outcome was assessed at 90 days post-SAH using the Modified Rankin Scale (mRS).

Statistical analyses:
The association between the outcome and the factors was assessed using the Pearson Chi-Square test and the risk factors/predictors of outcome were assessed using logistic regression.

Results:
The following variables were important risk factors for predicting poor outcome of angio-negative SAH (mRS 3 to 6): hypertension (P = 0.011), diabetes mellitus (P = 0.032), being an alcoholic (P = 0.019), HHS grade 4 to 5 (P < 0.01), and WFNS grade 4 to 5 (P < 0.01). On multivariate regression analysis, hypertension (P = 0.032) was an independent predictor of unfavorable outcome.

Conclusions:
At time of admission, presence of hypertension, diabetes mellitus, history of alcohol consumption, and poor grades of HHS and WFNS scale are predictors of poor outcome of angio-negative SAH.
Tyrosine kinase domain mutations in chronic myelogenous leukemia patients: A single center experience
Authors: Bommannan KB , Naseem S , Binota J , Varma N , Malhotra P , Varma S 
Published: November 2021

Introduction:
Despite the impressive responses achieved with tyrosine kinase inhibitor (TKI) therapy, treatment resistance develops in 16–33% of patients of chronic myelogenous leukemia (CML). Of the BCR-ABL1 dependent mechanisms, mutations in the tyrosine kinase domain (TKD) are the commonest cause of resistance.

Material and Methods:
Allele specific oligonucleotide - polymerase chain reaction (ASO-PCR) was done for testing the six common TKD mutations, T315I, G250E, E255K, M244V, M351T, and Y253F.

Results and Conclusion:
TKD mutation study was done on 83 patients. Of these 44 (53%) were positive for one or more mutations. On analyzing specific mutations, E255K was the commonest mutation seen in 24 (29%) cases, followed by T315I in 23(28%) cases. Y253F mutation was not seen in the present study sample. In the present cohort of 83 patients, 29 (35%) cases were positive for single mutation, 12 (14%) had two mutations and 3 (4%) had three mutations.
Short versus long esophageal myotomy during peroral endoscopic myotomy
Authors: Nabi Zaheer , Talukdar Rupjyoti , Mandavdhare Harshal , Reddy D. Nageshwar 
Published: November 2021

Background:
Peroral endoscopic myotomy (POEM) is an established modality of treatment for achalasia cardia. Considerable variations exist in the technique of POEM with respect to the length and orientation of the myotomy. In this systematic review and meta-analysis, we compared the outcomes of short versus long myotomy during POEM.

Methods:
We searched multiple databases from January 2010 to March 2021 to identify studies reporting on POEM. We selected studies that reported on comparative outcomes of POEM using short versus long myotomy. We performed a comparative analysis of clinical success, procedural duration, gastroesophageal reflux disease (GERD), and adverse events with short and long myotomy in POEM by meta-analysis.

Results:
A total of 521 patients from five studies in which 241 patients were treated with short and 280 patients with long myotomy approaches were analyzed. The pooled rate for clinical success gave an odds ratio (OR) of 1.27 (95% confidence interval [CI] 0.50–3.26; I2 = 0; P = 0.62); for hospital stay OR 0.22 (95% CI − 0.03 to 0.46; I2 = 0; P = 0.08); for GERD by esophagogastroduodenoscopy (EGD) OR 0.58 (95% CI 0.31–1.07; I2 = 0; P = 0.08), and for adverse events OR 0.67 (95% CI 0.29–1.53; I2 = 51; P = 0.34). Abnormal esophageal acid exposure was less frequent with OR 0.45 (95% CI 0.22–0.90; P = 0.02; I2 = 0) and the procedure duration was significantly shorter in the short myotomy group with OR − 0.76 (95% CI − 1.00 to − 0.52; I2 = 43; P =0.001).

Conclusion:
Short myotomy and long myotomy in POEM seem comparable with each other in terms of clinical success and adverse events. Short myotomy is associated with significantly shorter procedural duration and possibly reduced esophageal acid exposure compared with long myotomy.
A study of the effect of combination of acupuncture and Chinese medicine (Ban Xia Xie Xin Decoction) on patients with sepsis-induced gastrointestinal dysfunction
Authors: Lv Yanfei , Dong Feng , Hao Hao , Kong Li , Kong Li 
Published: November 2021

Purpose: To investigate the therapeutic effect of combination of acupuncture and Ban Xia Xie Xin Decoction (BXXXD) in patients with sepsis-induced gastrointestinal dysfunction.Methods: A total of 100 patients with sepsis and gastrointestinal dysfunction admitted to our hospitalfrom June 2019 to December 2020 were randomly assigned to a control group and a study group for a retrospective analysis. Both groups received acupuncture treatment, while BXXXD was given to the study group, in addition to acupuncture. Treatment effectiveness, incidence of adverse reactions, degree of recurrence at 1, 2 and 3 months after treatment, gastrointestinal dysfunction scores after 1week of treatment, quality of life index (QLI) scores, frequencies of flatulence and defecation within 48 h, number of bowel rumblings, as well as levels of gastrin and cholecystokinin (CCK), were determined and compared between the two groups.Results: The group with BXXXD intervention demonstrated superior treatment effectiveness, QLI cores, frequencies of flatulence and defecation within 48 h, number of bowel rumblings, and level of gastrin than those who received only acupuncture treatment (p < 0.05). There was strong evidence of lower incidence of adverse reactions, recurrence at 1, 2, and 3 months after treatment; gastrointestinal dysfunction scores and CCK levels after 1 week of treatment was higher in the study group than in the control group (p < 0.05).Conclusion: The combination of acupuncture and BXXXD is superior to acupuncture alone in sepsis patients with gastrointestinal dysfunction. The combination therapy produces its effect by decreasing clinical symptoms, promoting recovery of the patients, and elevating their quality of life.
Rapid Review: Diagnostic Accuracy of Pooled Testing versus Individual Testing Using RT-PCR for SARS-CoV-2 for Screening and Surveillance of Individuals with Suspected COVID-19
Authors: Genuino Rowena Natividad F. , Tiangco Beatrice J. , Besa John Jefferson V. , Bayona Howell Henrian G. 
Published: November 2021

Background. Pooled testing has been implemented on a limited scale, mainly for screening and surveillance in populations with a low prevalence of COVID-19 to save on limited resources.
Objective. To determine the diagnostic accuracy of pooled compared with individual RT-PCR testing for SARS-CoV-2 in individuals suspected of COVID-19.
Methods. We searched websites of living CPGs on COVID-19 (Australian COVID-19, COVID NMA, CEBM Oxford), Philippine DOH HTA, databases (PubMed, CENTRAL, medRXIV/bioRXIV), and Clinicaltrials.gov for studies that used pooled testing on individuals suspected of COVID-19. When appropriate, we pooled data for sensitivity and specificity and obtained the range and median of other data, such as positive predictive value and resource savings. We did a priori subgroup analysis for pool size, presence or absence of symptoms and use case, type of specimen, cutoff for positivity, type of kit, and post hoc subgroup analysis for method of pooling and timing of processing.
Results. We included 21 studies: 6 diagnostic accuracy studies, and 15 clinical validation studies. Studies had varying populations, index test kit and performance characteristics, positivity rate (0.02 to 15%), and pool size (5 to 16). There was moderate pooled sensitivity, 81% (95% CI 72, 88; I2=73.6%; 6 studies, 776 pools) and high pooled specificity, 99% (95% CI, 98 to 100; I2=1.84%; 5 studies, 666 pools). Positive predictive value based on 21 studies ranged from 67% to 100%. Resource savings in the number of test kits used ranged from 49 to 89%. Identified harms of pooled testing were delayed turnaround time for positive samples and laboratory errors.
Conclusion. There is moderate sensitivity and high specificity with pooled testing for the screening of individuals with suspected COVID-19. We recommend further studies to validate the utility based on community prevalence and other test variables.
TESS observations of KIC 7739728 - a new FK Com type star candidate
Authors: Саванов И.С. , Дмитриенко Е.С. 
Published: November 2021

Ранее по данным наблюдений с космическим телескопом “Kepler” нами было показано, что по своим параметрам KIC 7739728 близка к звездам типа FK Com и может рассматриваться, как потенциальный кандидат для включения в число объектов этого типа. В настоящей работе мы провели анализ всех имеющихся для KIC 7739728 данных в архиве миссии TESS (14 и 26 сектора наблюдений). Показано, что кривая блеска этой звезды ярко проявляет свойства регулярной вращательной модуляции и что в период времени между 14 и 26 секторами произошло явление переключения положений долгот активных областей на поверхности звезды (флип-флоп). Рассматриваются аргументы в пользу возможной принадлежности KIC 7739728 к объектам типа FK Com.
Using the observations with the Kepler space telescope we found that parameters of KIC 7739728 are close to that ones of the FK Com type stars and that the object can be considered as a potential candidate for inclusion in the number of objects of this type. In this paper we analysed all available data for KIC 7739728 in the TESS mission archive (14 and 26 sectors). It is shown that the light curve of this star clearly exhibits the properties of regular rotational modulation and that in the time interval between 14 and 26 sectors the phenomenon of switching the positions of the longitudes of the active regions on the surface of the star (flip-flop) occurred. The arguments in favour of the possible relation of KIC 7739728 to objects of the FK Com type are considered.
Mechanical Characteristic and Water Absorption Property of Bio Composite from Sago Starch and Jute Fiber (Boehmeria Nivea) as the filler
Authors: Dewi Rozanna , Oktaviani Oktaviani , Ginting Zainuddin , Sylvia Novi 
Published: November 2021

Environmentally friendly plastics can be degraded biologically in an anaerobic environment. This plastic is synthesized from starch such as sago starch which is available in abundance. In the form of bioplastics, its mechanical properties are still not compared to conventional plastics derived from crude oil, so its application is limited. The incorporation of filler material increases its mechanical properties, one of the selected fillers is hemp fiber as used in this study. Thermoplastic starch from sago with flax fiber as a filler and the addition of Polypropylene to improve mechanical properties with a certain composition to maintain its natural biodegradability. The mechanical properties analyzed were tensile strength, elongation and modulus of elasticity. Water absorption tests were also carried out to observe the water resistance properties. The results of the tensile strength test showed that the best tensile strength value of 9.32 Mpa was obtained at the addition of 35% fiber with a TPS: PP ratio of 1:1.5. The same conditions were obtained for the percent elongation with the results of 10.16% and the modulus of elasticity was 91.73 Mpa. Water absorption showed that 55% filler gave the lowest water absorption, namely 4.41% at a ratio of TPS: PP 1:0.5. The addition of fiber filler into the bio-composite affects the tensile strength, elongation and modulus of elasticity, the higher the volume of filler entering the bio-composite, the lower the value of tensile strength, elongation and modulus of elasticity, or vice versa. The ratio of addition of polypropylene matrix is also influential, the higher the ratio contributes to the tensile strength, elongation and higher modulus of elasticity. High water absorption capacity will reduce the performance of biocomposite, so the lower the water absorption ability, the better the quality of the biocomposite product and the wider its application
Анализ пространственных закономерностей воздействий промышленных взрывов на эколого-геологические системы горнодобывающих районов
Authors: Косинова Ирина Ивановна , Надёжка Людмила Ивановна , Лисецкий Федор Николаевич , Бударина Виктория Александровна , Семёнов Александр Евгеньевич , Павловский Александр Илларионович 
Published: November 2021

В настоящее время техногенные воздействия на среду обитания человека в значительной мере определяют степень ее комфортности. Горнодобывающая деятельность оказывает многопрофильное и интенсивное воздействие на компоненты окружающей природной среды. В связи с недостаточной изученностью данных процессов авторами проведен анализ временных и пространственных закономерностей воздействий промышленных взрывов на эколого-геологические системы горнодобывающих районов, дана характеристика сейсмических событий, возникающих при взрывах. Показано, что наблюдаемое увеличение интенсивности фоновых микросейсмических колебаний, изменение их спектрального состава под воздействием промышленных взрывов, а также регулярность проведения взрывов в разных карьерах оказывают значительное влияние на степень комфортности среды обитания и здоровье человека. Впервые выявлены радиусы формирования дискомфортной среды обитания в горнодобывающих районах, которые составляют 3000 м; нарушение устойчивости инженерных сооружений фиксируется на расстоянии до 50 км от источника; явления наведенной сейсмичности формируются в радиусе до 200 км от места проведения промышленных взрывов. Полученные результаты могут быть использованы в практике инженерного, строительного, селитебного и иных видов освоения территорий.
Detection of risk factors of PCOS patients with Local Interpretable Model-agnostic Explanations (LIME) Method that an explainable artificial intelligence model
Authors: BALIKÇI ÇİÇEK İpek , KÜÇÜKAKÇALI Zeynep , YAĞIN Fatma Hilal 
Published: November 2021

Aim: In this study, it is aimed to extract patient-based explanations of the contribution of important features in the decision-making process (estimation) of the Random forest (RF) model, which is difficult to interpret for PCOS disease risk, with Local Interpretable Model-Agnostic Explanations (LIME).
Materials and Methods: In this study, the Local Interpretable Model-Agnostic Annotations (LIME) method was applied to the “Polycystic ovary syndrome” dataset to explain the Random Forest (RF) model, which is difficult to interpret for PCOS risk factors estimation. This dataset is available at https://www.kaggle.com/prasoonkottarathil/polycystic-ovary-syndrome-pcos.
Results: Accuracy, sensitivity, specificity, positive predictive value, negative predictive value and balanced accuracy obtained from the Random Forest method were 86.03%, 86.32%, 85.37%, 93.18%, 72.92% and 85.84% respectively. According to the obtained results, the observations whose results were obtained, the values of Follicle (No) L. and Follicle (No) R. in different value ranges were positively correlated with the absence of PCOS. For the observations whose absence of PCOS results were obtained, the variables RBS(mg/dl), bmi_y, fsh_lh, TSH (mIU/L), Endometrium (mm) also played a role in obtaining the results. In addition, for the observations whose results were obtained, the values of Follicle No L and Follicle No R in different value ranges were also found to be positively correlated with PCOS. In addition, beta-HCG(mIU/mL), PRG(ng/mL), RBS(mg/dl), bmi_y, Endometrium (mm), fsh_lh variables also played a role in obtaining the results for PCOS.
Conclusion: When the observations obtained from the results are examined, it can be said that the Follicle (No) L. and Follicle (No) R. variables are the most effective variables on the presence or absence of PCOS. For different value ranges of these two variables, the result of PCOS or not varies. Based on this, it can be said that different values of Follicle (No) L. and Follicle (No) R. variables for PCOS status may be effective in determining the disease.
CASSITERITE U-Pb GEOCHRONOLOGY OF THE SANTA BÁRBARA TIN DISTRICT, RONDÔNIA TIN PROVINCE, BRAZIL
Authors: Guimarães Frederico Sousa , Zhang Rongqing , Lehmann Bernd , Raphael Cabral Alexandre , Rios Francisco Javier 
Published: November 2021

Abstract
The Mesoproterozoic Rondônia Tin Province of the Amazonian craton records a protracted history of about 600 m.y. of successive rare-metal granite intrusions and hosts the youngest known event of tin-granite emplacement of the craton—a rare-metal granite suite known as the Younger Granites of Rondônia intrusive suite. The ~1 Ga suite is currently interpreted as intracratonic magmatism resulting from a Grenvillian-age orogeny during the assembly of Rodinia. The Santa Bárbara massif is a tin-granite system of the Younger Granites of Rondônia intrusive suite that hosts Sn-Nb-Ta-W–bearing endogreisen and stockwork, as well as important placer deposits. The Santa Bárbara mine produces about 800 to 1,000 t Sn/year from placers and weathered greisen and represents about 20% of the tin mine output of the Rondônia Tin Province. Here, we report laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) cassiterite U-Pb ages of 989 ± 3 and 987 ± 6 Ma for the Santa Bárbara greisen and the cassiterite-quartz vein system, respectively. Alluvial cassiterite from placer mining has a U-Pb age of 995 ± 4 Ma, which is, within uncertainty, indistinguishable from those of primary cassiterite. These ages agree well with the previously published zircon and monazite U-Pb ages for the Santa Bárbara granite (978 ± 13 and 989 ± 13 Ma), which indicate a coeval relationship between hydrothermal tin mineralization and granite magmatism. The previously suggested 20- to 30-m.y. time span between granite magmatism and hydrothermal tin mineralization, which was based on mica K-Ar and Ar-Ar age data, is likely due to younger thermal disturbance of the isotopic systems.
Direito e ciência na teoria pura do direito E o problema da liberdade em Kelsen
Authors: Bruno Flávio Marcelo Rodrigues 
Published: November 2021

O estudo destina-se a abordar a relação entre o direito e a ciência na Teoria Pura do Direito e o problema da cientificidade na literatura de Hans Kelsen, inicia-se a abordagem com a análise entre a norma jurídica e a proposição jurídica, após uma realiza-se uma abordagem entre a causalidade (ser) e a imputação (dever-ser), expõe-se a ideia kelseneana de norma fundamental e por fim, coloca-se o complexo problema da liberdade na obra deste importante autor da literatura jurídica concluindo que o respostas a este problema só serão encontradas quando atendidas as exigências da ciência. O que se observa é que a norma fundamental defendida por Kelsen é necessária sim para o teórico do direito, aquele que tem a função de explicar a validade do direito, explicar de onde vem a força do direito - se do ser ou do dever-ser, ou seja, de um fato ou de uma norma -, mas não para o prático do direito, pois a norma fundamental, como já frisado, é uma norma hipotética, não tem conteúdo, e é justamente disso que precisam os operadores do direito para aplicarem a norma.

The study is intended to address the relationship between law and science in the Pure Theory of Law and the problem of scientificity in Hans Kelsen's literature. an approach is made between causality (being) and imputation (should-be), it exposes the Kelsenean idea of ​​fundamental norm and, finally, the complex problem of freedom in the work of this important author of legal literature is presented, concluding that the answers to this problem will only be found when the demands of science are met. What is observed is that the fundamental norm defended by Kelsen is indeed necessary for the legal theorist, who has the function of explaining the validity of the law, explaining where the force of law comes from - whether of being or of the should-be , that is, of a fact or a norm -, but not for the legal practitioner, as the fundamental norm, as already emphasized, is a hypothetical norm, has no content, and this is precisely what the operators of the law need to apply the standard..
Las representaciones rupestres y la posible temática de la zoofilia en el parque nacional Serra da Capivara, Piauí, Brasil: un estudio de caso
Authors: Justamand Michel , Buco Cristiane de Andrade , De Almeida Vitor José Rampaneli , Gomes Filho Antoniel dos Santos , Queiroz Albérico , De Oliveira Gabriel F. , De Oliveira Matteus Freitas , Paiva Leandro 
Published: November 2021

The present article intends to present the scenes of rupestrian representations of the zoophilia relationships, present in one of the artistic traditions of our ancestors in the reigão, the Nordeste Tradition, of Rock Art, as they are known by the scholars, in the Serra da Capivara National Park – PNSC, Piuaí, Brazil. These representations were collected in field work by some of the authors. We carried out the work between 2014 and 2018. They have sex between humans and a variety of non-human.

El presente artículo pretende presentar las escenas de representaciones rupestres de las relaciones de zoofilia, presentes en una de las tradiciones artísticas de nuestros antepasados en el reigão, la Tradición Nordeste, del Arte Rupestre, como la conocen los estudiosos, en la Serra da Parque Nacional Capivara - PNSC, Piuaí, Brasil. Estas representaciones fueron recopiladas en el trabajo de campo por algunos de los autores. Realizamos el trabajo entre 2014 y 2018. Tienen relaciones sexuales entre humanos y una variedad de no humanos.
A Synoptic analogue model to issue QPF over Gangetic West Bengal and adjoining Jharkhand
Authors: CHATTOPADHYAY S. , SENGUPTA S. 
Published: November 2021

In this study the Areal Average Precipitation (AAP) data for each day over each of the six catchments of Gangetic West Bengal (GWB) and adjoining Jharkhand namely river catchments of Mayurakhshi, Ajoy, Kansabati, Damodar, Barakar and Lower Valley of Damodar Valley Corporation during monsoon season for 25 years from 1990 to 2014 have been analyzed by grouping the AAP in three different ranges (11-25 mm, 26-50 mm, 51-100 mm and more), excluding Mainly Dry and 01-10 mm. The associated main synoptic features viz., trough at mean sea level, low pressure area, well marked low pressure area, cyclonic storm and cyclonic circulation for each day and their location with respect to the river catchments, viz., over the catchment, neighbourhood of the catchment (within 200 km South or North) and outside the catchment (more than 200 km South or North) have also been studied. The association of AAP ranges over six catchments with different categories of synoptic features has been examined. The distribution of percentage frequency of AAPs associated with the category of synoptic feature for the period 1990 to 2014 has led to development of a Synoptic Analogue Model (SAM) for issue of Quantitative Precipitation Forecast (QPF). The results obtained from SAM have been verified for rainfall data and calculated AAPs of monsoon season of 2015 over all the catchments and different skills scores also presented in this study.