bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil response to root-knot nematode management with wine vinasse in a solarised horticultural soil under glasshouse conditions
Authors: López-Pérez Jose A. , Sánchez-Moreno Sara 
Published: December 2021

Summary
The increasing interest in agroecological practices and the current consideration of agrarian soils as a sustainable resource are driving the development of new strategies to manage soil parasites and diseases. The application of organic matter from different sources to reduce plant parasites contributes to circular economy by applying by-products as soil organic amendments that reduce wastes. Wine vinasse (WV) is a by-product generated to obtain alcohol from wine by physical methods in distilleries. The aim of this study was to determine the potential of WV and its combination with animal manure (WV+M) as soil biodisinfestation products. For this, it was compared with a plastic-covered control to distinguish the biodisinfestation from solarisation effect. The crops tested consisted of a tomato-Swiss chard rotation under glasshouse conditions. Their effects on Meloidogyne incognita, soil fertility, nematode community and crop yield were assessed. The results obtained after two seasons showed a reduction of M. incognita galling in the root system of both crops. The immediate effect after the treatment application was a reduction in the abundance of nematodes and changes in the nematode-based indices that affected all plots, including the control, most likely related to the tillage effect for the treatments application and the plastic cover. Soil fertility was improved by the application of WV (NO3−, Bioav. P) and WV+M (C, Ntotal, K), which reduced herbivore nematode metabolic footprints and enhanced bacterivore footprints. Our results indicate that the combination WV+M was effective reducing M. incognita infection, and improved crop yield. Use of by-products such as WV is a helpful tool for managing horticultural soils.
Identifying, Categorising and Exploring ‘Ælfrician’ Vocabulary Using the Dictionary of Old English, A Thesaurus of Old English and Evoke
Authors: van Baalen Amos 
Published: December 2021

Abstract
Ælfric of Eynsham (c.955×957–c.1010) is one of the most prominent authors of the Anglo-Saxon period. Despite this fact, there has not yet been an exhaustive study into his typical vocabulary. This article employs the Dictionary of Old English and prior scholarship in order to collect and categorise the lexis that is characteristic for his works. This vocabulary is then analysed using the web application Evoke together with A Thesaurus of Old English, which provides insights into the semantic domains that predominate in Ælfric’s vocabulary, as well as the degrees of ambiguity, synonymy and specificity of his typical lexis.
Avoidance of final monopositional vowels
Authors: Shachmon Ori , Faust Noam 
Published: December 2021

Abstract
A group of Arabic dialects in Yemen exhibit a velar k in the subject suffixes of the perfect paradigm. The 1sg subject suffix surfaces in the various dialects as -ku, -k or -kw. In addition, the vocalization of the base may or may not be colored with a round vocalic quality, depending on both the realization of the suffix and the verbal type faʿal or fiʿil. Based on inquiries among speakers from Lower Yemen, we propose a path of evolution that leads from -ku to the labialized -kw, to a “colored” stem, and finally to the grammaticalization of coloration and loss of labialization. Two pressures propel the passage between stages: a functional pressure to distinguish between 1sg and 2msg, and a phonological pressure to avoid monopositional final vowels. The phonological pressure is shown to also motivate palatalization in the 2fsg -ki ⇒ -ky (⇒ -š), as well as the effect of pre-pausal nasal insertion, viz. -ku ⇒ -kum# and -ki ⇒ -kiŋ#. We further show that final vowels resulting from the interaction of the subject suffixes with object clitics are phonologically long—even if phonetically neutralized—and hence they do not violate the phonological requirement. The formal theories of strict CV (Lowenstamm 1996, Scheer 2004) and Element Theory (Kaye et al. 1985) are used to explain the a-synchronized development in the different verbal patterns, as well as the extent of the phonological ban on monopositional vowels.
Active participles in Jordanian Arabic
Authors: Al-Raba’a Basem Ibrahim Malawi 
Published: December 2021

Abstract
This study examines the categorial status, syntactic derivation, and tense of active participles in an urban variety of Jordanian Arabic. It is shown that unlike in other Arabic varieties, active participles in Jordanian Arabic fall into three distinct categories (namely, nominal, adjectival, and verbal) with respect to their morphophonological, syntactic and semantic structures. Moreover, it is argued that active participles are not lexically underspecified or homophonous, but are rather derived distinctively in the syntax. This study also explores tense in active participle clauses. Verbless clauses with adjectival and nominal active participles as the only predicates solely project present tense; a past or future tense is available only if a copula is involved. In contrast, clauses with verbal active participles, which are morphologically unmarked for tense, are shown to license temporal adverbs of different time references. It is argued that such clauses project a covert agreement tense whose time frame is established by time adverbs.
Where in the World are Chinese Women Filmmakers? Transnational China and World Cinema in the Twenty-First Century
Authors: Marchetti Gina 
Published: December 2021

Abstract
Transnational Chinese women filmmakers reflect the enormous changes happening in the global film industry as well as political, economic, technological, social, and cultural transformations taking place in the region since the beginning of the millennium. An analysis of Hong Kong writer-director Aubrey Lam’s Anna & Anna (2007) uncovers how this film explores the divided psyche of a woman torn between “two systems” that model femininity for women in Singapore and Shanghai in the 21st century. Lam’s narrative touches on issues central to the work of many women working across the Chinese-speaking world including migration, labor relations, postcolonial and postsocialist identities, commodification of female bodies in consumer culture, cross-border sexualities, female desire and domesticity.
Overt speech critically changes lateralization index and did not allow determination of hemispheric dominance for language: an fMRI study
Authors: Berro David Hassanein , Lemée Jean-Michel , Leiber Louis-Marie , Emery Evelyne , Menei Philippe , Ter Minassian Aram 
Published: December 2021

Abstract
Background
Pre-surgical mapping of language using functional MRI aimed principally to determine the dominant hemisphere. This mapping is currently performed using covert linguistic task in way to avoid motion artefacts potentially biasing the results. However, overt task is closer to natural speaking, allows a control on the performance of the task, and may be easier to perform for stressed patients and children. However, overt task, by activating phonological areas on both hemispheres and areas involved in pitch prosody control in the non-dominant hemisphere, is expected to modify the determination of the dominant hemisphere by the calculation of the lateralization index (LI).

Objective
Here, we analyzed the modifications in the LI and the interactions between cognitive networks during covert and overt speech task.

Methods
Thirty-three volunteers participated in this study, all but four were right-handed. They performed three functional sessions consisting of (1) covert and (2) overt generation of a short sentence semantically linked with an audibly presented word, from which we estimated the “Covert” and “Overt” contrasts, and a (3) resting-state session. The resting-state session was submitted to spatial independent component analysis to identify language network at rest (LANG), cingulo-opercular network (CO), and ventral attention network (VAN). The LI was calculated using the bootstrapping method.

Results
The LI of the LANG was the most left-lateralized (0.66 ± 0.38). The LI shifted from a moderate leftward lateralization for the Covert contrast (0.32 ± 0.38) to a right lateralization for the Overt contrast (− 0.13 ± 0.30). The LI significantly differed from each other. This rightward shift was due to the recruitment of right hemispheric temporal areas together with the nodes of the CO.

Conclusion
Analyzing the overt speech by fMRI allowed improvement in the physiological knowledge regarding the coordinated activity of the intrinsic connectivity networks. However, the rightward shift of the LI in this condition did not provide the basic information on the hemispheric language dominance. Overt linguistic task cannot be recommended for clinical purpose when determining hemispheric dominance for language.
Torsades de pointes in the PACU after outpatient endoscopy: a case report
Authors: Schaar Andrew , Liu Mark , Patzkowski Michael 
Published: December 2021

Abstract
Background
This case demonstrates the severe electrolyte derangements that may present after a common therapy such as a bowel preparation for an outpatient procedure and the rare yet potential detrimental outcomes of those abnormalities. It also highlights the implications of long QT syndrome regarding pharmacology and treatment.

Case presentation
We present a case of 48 year-old female with severe electrolyte derangements and long QT syndrome (LQTS) leading to Torsades de Pointes (TdP), pulseless ventricular fibrillation, and unsynchronized defibrillation in the post anesthesia care unit (PACU) after uneventful upper and lower endoscopy. This led to an unanticipated intensive care unit admission for aggressive electrolyte repletion, cardiology consultation, and implantable cardioverter defibrillator (ICD) placement.

Conclusions
This is a rare presentation after an outpatient procedure that would have had a detrimental outcome if not promptly diagnosed and treated appropriately. Therefore, we aim to provide further insight into the diagnosis and treatment of severe hypokalemia and long QT syndrome resulting in Torsades de Pointes and ventricular fibrillation.
Concordance rate of a four-quadrant plot for repeated measurements
Authors: Hiraishi Mayu , Tanioka Kensuke , Shimokawa Toshio 
Published: December 2021

AbstractBackgroundTo assure the equivalence between new clinical measurement methods and the standard methods, the four-quadrant plot and the plot’s concordance rate is used in clinical practice, along with Bland-Altman analysis. The conventional concordance rate does not consider the correlation among the data on individual subjects, which may affect its proper evaluation.MethodsWe propose a new concordance rate for the four-quadrant plot based on multivariate normal distribution to take into account the covariance within each individual subject. The proposed concordance rate is formulated as the conditional probability of the agreement. It contains a parameter to set the minimum concordant number between two measurement methods, which is regarded as agreement. This parameter allows flexibility in the interpretation of the results.ResultsThrough numerical simulations, the AUC value of the proposed method was 0.967, while that of the conventional concordance rate was 0.938. In the application to a real example, the AUC value of the proposed method was 0.999 and that of the conventional concordance rate was 0.964.ConclusionFrom the results of numerical simulations and a real example, the proposed concordance rate showed better accuracy and higher diagnosability than the conventional approaches.
Joint reconstruction framework of compressed sensing and nonlinear parallel imaging for dynamic cardiac magnetic resonance imaging
Authors: Hu Zhanqi , Zhao Cailei , Zhao Xia , Kong Lingyu , Yang Jun , Wang Xiaoyan , Liao Jianxiang , Zhou Yihang 
Published: December 2021

AbstractCompressed Sensing (CS) and parallel imaging are two promising techniques that accelerate the MRI acquisition process. Combining these two techniques is of great interest due to the complementary information used in each. In this study, we proposed a novel reconstruction framework that effectively combined compressed sensing and nonlinear parallel imaging technique for dynamic cardiac imaging. Specifically, the proposed method decouples the reconstruction process into two sequential steps: In the first step, a series of aliased dynamic images were reconstructed from the highly undersampled k-space data using compressed sensing; In the second step, nonlinear parallel imaging technique, i.e. nonlinear GRAPPA, was utilized to reconstruct the original dynamic images from the reconstructed k-space data obtained from the first step. In addition, we also proposed a tailored k-space down-sampling scheme that satisfies both the incoherent undersampling requirement for CS and the structured undersampling requirement for nonlinear parallel imaging. The proposed method was validated using four in vivo experiments of dynamic cardiac cine MRI with retrospective undersampling. Experimental results showed that the proposed method is superior at reducing aliasing artifacts and preserving the spatial details and temporal variations, compared with the competing k-t FOCUSS and k-t FOCUSS with sensitivity encoding methods, with the same numbers of measurements.
Diagnosis experiences from 50 hepatitis B patients in Chongqing, China: a qualitative study
Authors: Zhou Xiangxi , Zhang Fan , Ao Yongping , Lu Chunli , Li Tingting , Xu Xianglong , Zeng Huan 
Published: December 2021

Abstract
Background
The aim of this study was to provide recommendations for reducing the impact of hepatitis B infection on patients with chronic hepatitis B by describing their experiences during the diagnosis process.

Methods
We conducted face-to-face interviews with 50 hepatitis B patients recruited by convenient sampling from an infectious diseases department of a teaching hospital in Chongqing, China from July to August 2019. Thematic analysis framework included interviewees’ social demographic characteristics, diagnosis approach, signs and symptoms before diagnosis, feelings after diagnosis, and doctor’s instructions.

Results
Most patients first detected hepatitis B through various types of physical examinations when the patients were asymptomatic or had only mild symptoms. Most patients were shocked, scared, or overwhelmed when they were diagnosed with hepatitis B. They were able to remember the doctor’s instructions about maintaining a healthy lifestyle, but not impressed by the doctor’s advice about regular follow-up liver function tests. The lack of regular follow-up has caused irreversible damage to some patients.

Conclusions
Most patients are passively diagnosed with hepatitis B due to their lack of awareness on active hepatitis B prevention. Patients need professional mental health care to overcome the negative emotions that following the diagnosis. Physicians’ instruction should emphasize the importance of regular follow-up liver function tests in addition to a healthy lifestyle.
CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis
Authors: Zhao Chen-xing , Yan Zi-xun , Wen Jing-jing , Fu Di , Xu Peng-peng , Wang Li , Cheng Shu , Hu Jian-da , Zhao Wei-li 
Published: December 2021

AbstractBackgroundEpstein-Barr virus (EBV) represents an important pathogenic factor of lymphoma and is significantly associated with poor clinical outcome of diffuse large B-cell lymphoma (DLBCL). Circular RNAs (circRNAs) play an essential role in lymphoma progression. However, the underlying mechanism of circRNA on DLBCL progression related to EBV remains largely unknown.MethodsCircRNA was screened by high-throughput sequencing in tumor samples of 12 patients with DLBCL according to EBV infection status. Expression of circEAF2, as well as the relationship with clinical characteristics and prognosis, were further analyzed in tumor samples of 100 DLBCL patients using quantitative real-time PCR. Gain- and loss-of-function experiments were conducted to investigate the biological functions of circEAF2 both in vitro and in vivo. The underlying mechanism of circRNA on DLBCL progression were further determined by RNA sequencing, RNA pull down assay, dual-luciferase reporter assay, rescue experiments and western blotting.ResultsWe identified a novel circRNA circEAF2, which was downregulated in EBV + DLBCL and negatively correlated with EBV infection and DLBCL progression. In EBV-positive B lymphoma cells, circEAF2 overexpression induced lymphoma cell apoptosis and sensitized lymphoma cells to epirubicin. As mechanism of action, circEAF2 specifically targeted EBV-encoded miR-BART19-3p, upregulated APC, and suppressed downstream β-catenin expression, resulting in inactivation of Wnt signaling pathway and inhibition of EBV + DLBCL cell proliferation. In EBV-positive B-lymphoma murine models, xenografted tumors with circEAF2 overexpression presented decreased Ki-67 positivity, increased cell apoptosis and retarded tumor growth.ConclusionsCircEAF2 counteracted EBV + DLBCL progression via miR-BART19-3p/APC/β-catenin axis, referring circEAF2 as a potential prognostic biomarker. Therapeutic targeting EBV-encoded miRNA may be a promising strategy in treating EBV-associated lymphoid malignancies.
Cancer associated-fibroblast-derived exosomes in cancer progression
Authors: Li Chao , Teixeira Adilson Fonseca , Zhu Hong-Jian , ten Dijke Peter 
Published: December 2021

AbstractTo identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of attention in recent years in particular with the advent of clinical successes achieved by targeting immune checkpoint inhibitors (ICIs). The TME consists of multiple cell types that are embedded in the extracellular matrix (ECM), including immune cells, endothelial cells and cancer associated fibroblasts (CAFs), which communicate with cancer cells and each other during tumor progression. CAFs are a dominant and heterogeneous cell type within the TME with a pivotal role in controlling cancer cell invasion and metastasis, immune evasion, angiogenesis and chemotherapy resistance. CAFs mediate their effects in part by remodeling the ECM and by secreting soluble factors and extracellular vesicles. Exosomes are a subtype of extracellular vesicles (EVs), which contain various biomolecules such as nucleic acids, lipids, and proteins. The biomolecules in exosomes can be transmitted from one to another cell, and thereby affect the behavior of the receiving cell. As exosomes are also present in circulation, their contents can also be explored as biomarkers for the diagnosis and prognosis of cancer patients. In this review, we concentrate on the role of CAFs-derived exosomes in the communication between CAFs and cancer cells and other cells of the TME. First, we introduce the multiple roles of CAFs in tumorigenesis. Thereafter, we discuss the ways CAFs communicate with cancer cells and interplay with other cells of the TME, and focus in particular on the role of exosomes. Then, we elaborate on the mechanisms by which CAFs-derived exosomes contribute to cancer progression, as well as and the clinical impact of exosomes. We conclude by discussing aspects of exosomes that deserve further investigation, including emerging insights into making treatment with immune checkpoint inhibitor blockade more efficient.
Development of islet organoids from human induced pluripotent stem cells in a cross-linked collagen scaffold
Authors: Sandilya Shruti , Singh Shashi 
Published: December 2021

AbstractIslets organoids would have value in the cell replacement therapy for diabetes apart from usual personalized drug screening routes. Generation of a large number of Islets like clusters, with ability to respond to glucose stimulation appears to be an ideal choice. In this study we have generated islet organoids with the ability to respond to glucose stimulation by insulin release. The source of the cells was an iPSC cell line differentiated into the pancreatic progenitors. These cells were assembled in matrigel or cross-linked collagen scaffold and compared for their efficacy to release insulin upon stimulation with glucose. The assembled organoids were examined by immunohistochemistry and expression of the relevant marker genes. The organoids showed expression of islet like markers in both - matrigel and crosslinked collagen scaffold. The islet organoids in both the cases showed release of insulin upon stimulation with glucose. The crosslinked collagen scaffold is quite stable and supports islet cells growth and function.
Learning our lesson: using past policies to improve digital and ethnic inequalities beyond the pandemic
Authors: Ramasawmy Mel , Poole Lydia , Banerjee Amitava 
Published: December 2021

AbstractCOVID-19 has had a disproportionate impact on ethnic minorities in the UK, raising questions about whether learning from the past few decades about the interplay between ethnicity and health inequalities has been effectively incorporated in current health policy. As digital health approaches, such as remote consultations and apps, become more widespread during and after the pandemic, it is important to ensure that these do not contribute to ‘widening the gap’. We highlight three areas in which existing knowledge and evidence can be translated into cross-sectoral action to avoid further ethnic and digital health inequalities: data and measurement, improved communication, and embedded equality impact.
How to make online mood-monitoring in bipolar patients a success? A qualitative exploration of requirements
Authors: Geerling B. , Kelders S. M. , Kupka R. W. , Stevens A. W. M. M. , Bohlmeijer E. T. 
Published: December 2021

Abstract
Background
The Life-Chart Method (LCM) is an effective self-management treatment option in bipolar disorder (BD). There is insufficient knowledge about the consumers’ needs and desires for an e-monitoring solution. The first step towards a new mood monitoring application is an extended inventory among consumers and professionals.

Methods
The aim of the current study was: to identify opinions about online mood monitoring of patients with BD and professionals and to identify preferences on design, technical features and options facilitating optimal use and implementation of online mood monitoring. This study used a qualitative design with focus-groups. Participants were recruited among patients and care providers. Three focus-groups were held with eight consumers and five professionals.

Results
The focus-group meetings reveal a shared consciousness of the importance of using the Life-Chart Method for online mood monitoring. There is a need for personalization, adjustability, a strict privacy concept, an adjustable graphic report, and a link to early intervention strategies in the design. Due to the fact that this is a qualitative study with a relative small number of participants, so it remains unclear whether the results are fully generalizable. We can’t rule out a selection bias.

Conclusions
This study demonstrates the importance of involving stakeholders in identifying a smartphone-based mood charting applications’ requirements. Personalization, adjustability, privacy, an adjustable graphic report, and a direct link to early intervention strategies are necessary requirements for a successful design. The results of this value specification are included in the follow-up of this project.