bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Langsung NGO dalam Pembuatan Kebijakan Luar Negeri Indonesia terkait Sampah Impor 2019: Studi Kasus ECOTON
Authors: Ali Yusril Ihza , Aryani Maria Indira 
Published: December 2021

In 2018, the world of global waste trade received a major shick that has an impact to both waste exporting countries and waste importing countries, and that was the closure of waste imports by China, which was the largest recipient country at that time through National Sword Policy. Exporting countries were forced to duvert their waste to the recipient countries that have not implemented new policies related to the imported waste such as Indonesia. As a result, Indonesia received a significant increase imported waste and cause a negative impact on various sectors, one of which was the environment sector. This then triggered some parties who have concerns regarding environmental issue such as ECOTON to resolve this issue by pressing the government to make new policies to stop imported waste that continues to degrade the environment.the author use a qualitative-descriptive method so that the authors can explain in detail and systematically the role of ECOTON in foreign policy making by using the theory of the direct role of NGOs in foreign policy making as the basis.
Reporte de hallazgo radiológico de hematoma intramural Duodenal posterior a uso de anticoagulantes
Authors: Vera Loor Gema Gabriela , Montesdeoca Santana Steffania Renata , Plaza Salazar Marieta , Bernabé Ruíz Jéssica 
Published: December 2021

Introducción: El hallazgo de hematoma intramural intestinal resulta rara, debido a múltiples factores, iniciando por su su baja incidencia,1 de cada 2500 pacientes en tratamiento con warfarina. Su aparición se asocia en un 90% a traumatismos abdominales, existiendo pocos casos reportados en relación a sobredosis de anticoagulantes. Es causa altamente infrecuente de dolor abdominal agudo, pero se convierte en un diagnóstico diferencial a tomar en cuenta en paciente con antecedentes de anticoagulación. En casos espontáneos su localización es más frecuente en el yeyuno (71.6%) seguido del duodeno (29.8%). Objetivo: Reportar este raro hallazgo radiológico. Metodología: En el presente artículo detallamos el raro hallazgo radiológico mediante tomografía computarizada de un hematoma intramural en intestino delgado específicamente en segunda y tercera porción del duodeno relacionado a anticoagulación; a partir del relato de un caso clínico reportado. Conclusión: El reporte de hallazgos radiológicos de entidades raras como lo es el hematoma intramural duodenal no traumático es importante y nutritivo en cuanto a evidencia científica, ampliando el abanico de opciones en pacientes con dolor abdominal no especificado con sospecha de sobredosis de anticoagulación
PENERAPAN APLIKASI SIPEDIS (SISTEM PENEGAKAN DISIPLIN) PADA KPPBC TMP B MAKASSAR
Authors: Saktiawan Iwan 
Published: December 2021

Direktorat Jenderal Bea dan Cukai dalam hal ini Kantor Pengawasan dan Pelayanan Bea dan Cukai Tipe Madya Pabean B Makassar telah mengatur mekanisme penegakan disiplin kepada para pejabat dan pegawai di seluruh satuan kerja yang mulai dimplementasikan. Telah disusun butir-butir yang mengatur pegawai agar disiplin dalam berpakaian dinas seragam dan pakaian olah raga (untuk senam Jumat pagi), disiplin dalam kehadiran dan jam kerja, serta disiplin dalam sikap dan perilaku. Permasalahan yang terjadi dalam implementasinya adalah proses pencatatan pelanggaran pegawai yang dilakukan oleh Tim Penegak Disiplin masih secara manual, belum paperless, serta diperlukan transparansi yang dapat diakses secara real time atas kontrol kedisiplinan seluruh pegawai. Tujuan dari penelitian ini adalah untuk membuat sebuah sistem aplikasi pencatatan pelanggaran dalam proses penegakan disiplin secara elektronik yang memudahkan Tim Penegak Disiplin dalam melakukan administrasi pelanggaran. Penelitian ini merupakan bentuk penelitian terapan yang dilakukan dengan pendekatan kualitatif. Metode pengumpulan data yang digunakan melalui observasi, wawancara, telaah dokumen, dan dokumentasi untuk mendapatkan informasi-informasi yang berhubungan dengan pengembangan pegawai dan informan dalam penelitian ini berjumlah 3 (tiga) orang. Penelitian ini menghasilkan sebuah aplikasi sebagai solusi memudahkan proses penegakan disiplin yang berbasis aplikasi, dapat diakses secara mobile, sehingga diharapkan dapat meningkatkan kedisiplinan pegawai, serta sarana monitoring pimpinan terhadap tingkat pelanggaran disiplin. Oleh karena itu, demi kelancaran proses penegakan disiplin pegawai di dalam organisasi, diperlukan pemanfaatan SIPEDIS (Sistem Penegakan Disiplin) sebagai sarana yang mampu memberikan kemudahan dalam implementasinya.
Perbedaan Karakteristik Serta Tingkat Pelayanan Pejalan Kaki Pada Kawasan Pedestrian Di Kota Kendari (TPKPP)
Authors: Rahayu Sri Fera , Magribi Muh. , Harimudin Jamal , Fitriani Fitriani 
Published: December 2021

Abstrak: Penelitian di kawasan perdagangan (Mall Mandonga) dan pendidikan (Universitas Halu Oleo) Penelitian ini telah dilaksanakan pada bulan Juli 2019 sampai Oktober 2019. Teknik pengumpulan data dilakukan dengan 1) survey melalui kuisioner dan wawancara terhadap responden 2) observasi pengamatan kegiatan fisik di lapangan 3) dokumentasi. Metode analisis data yang digunakan yaitu analisis karakteristik pejalan kaki, tingkat pelayanan jalan kaki dan tingkat kepuasan pejalan kaki kemudian dijelaskan secara deskriptif. Hasil penelitian menunjukkan bahwa tingkat pelayanan fasilitas pejalan kaki pada kawasan pendidikan di Universitas Halu Oleo adalah C dengan pejalan kaki memiliki arus stabil tetapi pejalan kaki dibatasi dalam memilih kecepatan dan sedikit ada konflik dengan tingkat pelayanan. Sedangkan tingkat pelayanan pejalan kaki pada kawasan perdagangan di Mall Mandonga adalah D dengan pejalan kaki memiliki arus mendekati tidak stabil sedangkan kecepatan masih bisa dikendalikan dan konflik yang terjadi di trotoar tersebut masih dapat ditolerir.. Kata Kunci : Karakteristik, Pejalan Kaki, Tingkat Pelayanan, Kawasan Pedestrian Abstrack: Research in the trade area (Mandonga Mall) and education (Halu Oleo University) This research was conducted in July 2019 to October 2019. Data collection techniques were carried out by 1) surveying through questionnaires and interviews with respondents 2) observing physical activity observations in the field 3) documentation. The data analysis method used is the analysis of pedestrian characteristics, the level of walking services and the level of pedestrian satisfaction then described descriptively. The results showed that the level of service of pedestrian facilities in the education area at Halu Oleo University is C with pedestrians having a steady flow but pedestrians are limited in choosing speed and there is little conflict with service levels. While the level of pedestrian services in the trade area at Mandonga Mall is D with pedestrians having an unstable approaching flow while speed can still be controlled and conflicts occurring on the sidewalk are still tolerable. Keywords: Characteristics, Pedestrians, Service Level, Pedestrian Region.
Analisis Pengembangan Kawasan Agropolitan Di Kecamatan Sinjai Barat
Authors: Hidayat Ahmad , Suratman Suratman , Hadmoko Danang Sri 
Published: December 2021

Abstrak: Kecamatan Sinjai Barat adalah merupakan salah satu kecamatan yang ditetapkan sebagai kawasan agropolitan. Luas wilayah Kecamatan Sinjai Barat adalah 13,53 km2 atau 16,53% dari luas total wilayah Kabupaten Sinjai. Penelitian ini bertujuan : 1) mengidentifikasi jenis komoditas unggulan; 2) mengetahui kesesuaian lahan; 3) mengidentifikasi pola sebaran spasial pengembangan kawasan agropolitan. Metode penelitian adalah metode deskriptif berupa pengumpulan dan pengolahan data lapangan, metode pemetaan, metode Location Quotient (LQ), dan metode matching pada software atau program Land Classification and Landuse Planning (LCLP). Hasil penelitian ini menunjukkan bahwa : 1) hasil perhitungan LQ komoditas padi, ketimun, sawi, kentang, wortel, kubis, tomat, serta buncis merupakan komoditas unggulan. 2) kelas kesesuaian lahan, padi dengan kelas kesesuaian lahan S2 (cukup sesuai) 329,49 Ha, S3 (sesuai marginal) 2821,77 Ha, kentang, wortel, sawi, buncis, dan tomat memiliki kelas kesesuaian lahan S2 742,02 Ha dan untuk kelas kesesuaian lahan S3 2409,24 Ha. Komoditas lainnya yakni ketimun dan buncis memiliki kelas kesesuaian lahan S2 742,02 Ha, S3 2062,82 Ha serta kelas kesesuaian lahan N (tidak sesuai) 346,42 Ha. 3) adapun luas lahan yang dapat digunakan untuk pengembangan komoditas padi 329,49 Ha, kentang, wortel dan tomat 1276,59 Ha, ketimun dan sawi 412,53 Ha, buncis 519,47 Ha serta kubis 613,18 Ha. Kata Kunci : Agropolitan, Komoditas Unggulan, LCLP, Kesesuaian Lahan
Analisis Tingkat Kekumuhan Permukiman Pesisir Di Kecamatan Abeli
Authors: Asyfa Asyfa , Ido Irfan , Nurgiantoro Nurgiantoro 
Published: December 2021

Abstrak: Penelitian ini bertujuan untuk menentukan indeks kekumuhan permukiman pesisir dan menganalisis kondisi eksisting permukiman di Kecamatan Abeli Kota Kendari dengan menggunakan analisis deskriptif kuantitatif. Penelitian ini menggunakan metode overlay dengan memberikan penilaian pada setiap indikator kekumuhan yang telah ditetapkan oleh Dirjen Perumahan dan Permukiman seperti: kepadatan bangunan, kelayakan bangunan, aksesibilitas lingkungan, drainase lingkungan, pelayanan air bersih, pengelolaan air limbah dan pengelolaan persampahan. Hasil penelitian menunjukkan bahwa indeks kekumuhan permukiman pesisir di Kecamatan Abeli terdiri dari dua kelas yaitu kumuh sedang dan kumuh berat. Kelas kumuh sedang dengan indeks kekumuhan 2,5-3,4 terdapat di Kelurahan Pudai RT 02, Kelurahan Lapulu RT 01 dan 02, Kelurahan Poasia RT 03 dan 05, Kelurahan Talia RT 01. Kelas kumuh berat dengan indeks kekumuhan 3,5- 4,4 terdapat pada Kelurahan Pudai RT 01, Kelurahan Lapulu RT 03 dan Kelurahan Talia RT 02, 03 dan 04. kondisi eksisting untuk tingkat permukiman kumuh sedang memiliki kondisi lingkungan umumnya cenderung menengah, dimana terdapat beberapa aspek yang memiliki kesamaan dengan permukiman kumuh ringan. Kondisi kumuh berat kondidsi lingkungannya buruk, terdapat kecenderungan bahwa semakin buruk tingkat kekumuhan permukiman, maka semakin buruk pula kondisinya dengan memilki kondisi sarana dan prasarana yang tidak memadai dan kondisi lingkungan yang kurang terjaga. Kata Kunci: permukiman kumuh, tingkat kekumuhan, overlay parameter Abstract: This study aims to determine the slum index of coastal settlements and analyze the existing conditions of settlements in Kendari City Abeli District using quantitative descriptive analysis. This study uses the overlay method by giving an assessment of each slum indicator set by the Director General of Housing and Settlements such as: building density, building feasibility, environmental accessibility, environmental drainage, clean water services, waste water management and waste management. The results showed that the slum index of coastal settlements in Abeli Subdistrict consisted of two classes namely medium slums and heavy slums. Where moderate slum with 2.5-3.4 slum index found in Pudai Village RT 02, Lapulu Village RT 01 and 02, Poasia Village RT 03 and 05, Talia Village RT 01. For heavy slum classes with 3.5- slum index 4.4 is found in Pudai RT 01 Village, Lapulu Village RT 03 and Talia RT 02, 03 and 04 Village. With the existing conditions for slum settlements having moderate environmental conditions generally tend to be medium, where there are several aspects that have similarities with light slum settlements . While the condition of heavy slum conditions is poor, there is a tendency that the worse the slum level of settlements, the worse the condition is by having inadequate conditions of facilities and infrastructure and adverse environmental conditions. Keywords: slum settlement, slum level, parameter overlay
Circulating Interleukin-7 in Human Pulmonary Arterial Hypertension
Authors: Diekmann Franziska , Legchenko Ekaterina , Chouvarine Philippe , Lichtinghagen Ralf , Bertram Harald , Happel Christoph M. , Hansmann Georg 
Published: December 2021

Objectives: Interleukin-7 (IL-7) secures B cell maturation, regulatory T and natural killer (NK) cell survival, and homeostasis, all of which are important for beneficial immunomodulation in pulmonary arterial hypertension (PAH). However, the role and potential impact of IL-7, VEGF-C and the vascular injury markers ICAM-1, and VCAM-1 on the pathobiology and severity of PAH is unknown.Methods: EDTA blood was collected during cardiac catheterization from the superior vena cava (SVC), pulmonary artery (PA), and ascending aorta (AAO) in children with pulmonary hypertension (PH) [n = 10; 9.1 (3.9–18.5) years] and non-PH controls [n = 10; 10.5 (2.0–17.3) years]. Compartment-specific plasma concentrations of IL-7, VEGF-C, aldosterone, ICAM-1, and VCAM-1 were determined using Meso Scale Discovery's multi array technology and the LIAISON Aldosterone Assay.Results: Children with PH had approximately 50% lower IL-7 (p &lt; 0.01) and 59% lower VEGF-C plasma levels (p &lt; 0.001) in the SVC, PA, and AAO versus non-PH controls. IL-7 and VEGF-C concentrations negatively correlated with the pulmonary vascular resistance (PVR)/systemic vascular resistance (SVR) ratio (rho = −0.51 and r = −0.62, respectively). Central-venous IL-7 strongly positively correlated with VEGF-C (r = 0.81). Most patients had a step down in ICAM-1 and VCAM-1 plasma concentrations across the pulmonary circulation and both ICAM-1 and VCAM-1 transpulmonary gradients negatively correlated with invasive hemodynamics.Conclusion: This manuscript is the first report on decreased circulating IL-7 and VEGF-C plasma concentrations in human PAH and their inverse correlations with invasive surrogates of PAH severity. Additional and larger studies are needed to explore the role of the immune-modulatory IL-7 and VEGF-C in pediatric and adult PAH.
Transverse Sinus Stenosis in Venous Pulsatile Tinnitus Patients May Lead to Brain Perfusion and White Matter Changes
Authors: Li Xiaoshuai , Xu Ning , Meng Xuxu , Dai Chihang , Qiu Xiaoyu , Ding Heyu , Lv Han , Zeng Rong , Xie Jing , Zhao Pengfei , Yang Zhenghan , Gong Shusheng , Wang Zhenchang 
Published: December 2021

Objective: Transverse sinus stenosis (TSS) is associated with various symptoms, but whether it can lead to pathological brain changes is unclear. This study aimed to investigate brain changes in venous pulsatile tinnitus (PT) patients with TSS.Materials and Methods: In this study, fifty-five consecutive venous PT patients and fifty age- and gender-matched healthy controls (HCs) were investigated. In CT venography, the combined conduit score (CCS) was used to assess the degree of TSS in venous PT patients. Magnetic resonance venography was used to assess TSS in HCs. All the participants had undergone arterial spin labeling and structural MRI scans.Results: Two patients without TSS and ten HCs with TSS were excluded. Fifty-three venous PT patients with TSS and 40 HCs without TSS were included in this study. All the patients had unilateral cases: 16 on the left and 37 on the right. Based on the CCS, the patients were divided into high-degree TSS (a score of 1–2) (n = 30) and low-degree TSS groups (a score of 3–4) (n = 23). In the whole brain and gray matter, the patients with high-degree TSS showed decreased cerebral blood flow (CBF) compared with patients with low-degree TSS as well as HCs (P &lt; 0.05), and no significant difference in CBF was found in patients with low-degree TSS and HCs (P &gt; 0.05). In white matter (WM) regions, the patients with high-degree TSS exhibited decreased CBF relative to the HCs (P &lt; 0.05). The incidence of cloud-like WM hyperintensity was significantly higher in the above two patient groups than in the HC group (P &lt; 0.05).Conclusion: TSS in venous PT patients may lead to decreased CBF and cloud-like WM hyperintensity. These neuroimaging findings may provide new insights into pathological TSS in venous PT.
Home-Based Transcranial Direct Current Stimulation for the Treatment of Symptoms of Depression and Anxiety in Temporal Lobe Epilepsy: A Randomized, Double-Blind, Sham-Controlled Clinical Trial
Authors: Mota Suelen Mandelli , Amaral de Castro Luiza , Riedel Patrícia Gabriela , Torres Carolina Machado , Bragatti José Augusto , Brondani Rosane , Secchi Thais Leite , Sanches Paulo Roberto Stefani , Caumo Wolnei , Bianchin Marino Muxfeldt 
Published: December 2021

We conducted a double-blind randomized clinical trial in order to examine the effects and the safety of home-based transcranial direct current stimulation (tDCS) on depressive and anxious symptoms of patients with temporal lobe epilepsy (TLE). We evaluated 26 adults with TLE and depressive symptoms randomized into two different groups: active tDCS (tDCSa) and Sham (tDCSs). The patients were first submitted to 20 sessions of tDCS for 20 min daily, 5 days a week for 4 weeks and then received a maintenance tDCS application in the research laboratory once a week for 3 weeks. The intensity of the current was 2 mA, applied bilaterally over the dorsolateral prefrontal cortex, with the anode positioned on the left side and the cathode on the right side. Participants were evaluated on days 1, 15, 30, and 60 of the study using the Beck Depression Inventory II (BDI). A follow-up evaluation was performed 1 year after the end of treatment. They were also evaluated for quality of life and for anxious symptoms as secondary outcomes. The groups did not differ in clinical, socioeconomic or psychometric characteristics at the initial assessment. There was no statistically significant difference between groups regarding reported adverse effects, seizure frequency or dropouts. On average, between the 1st and 60th day, the BDI score decreased by 43.93% in the active group and by 44.67% in the Sham group (ΔBDIfinal – initial = −12.54 vs. −12.20, p = 0.68). The similar improvement in depressive symptoms observed in both groups was attributed to placebo effect and interaction between participants and research group and not to tDCS intervention per se. In our study, tDCS was safe and well tolerated, but it was not effective in reducing depressive or anxiety symptoms in patients with temporal lobe epilepsy.Clinical Trial Registration: [ClinicalTrials.gov], identifier [NCT03871842].
Case Report: Five Adult Cases of H3K27-Altered Diffuse Midline Glioma in the Spinal Cord
Authors: Gu Quanquan , Huang Yajing , Zhang Hao , Jiang Biao 
Published: December 2021

BackgroundDiffuse midline glioma with H3K27-altered (DMG-H3K27a) is a novel tumor entity of the pediatric-type diffuse high-grade tumor in the latest WHO CNS 5. It mostly affects children and is only rarely found in adults. The tumor has a high level of aggressiveness, with a rapid progression and bad prognosis. In adults, the spinal cord is the most common site of DMG-H3K27a. Rare adult cases of primary DMG-H3K27a in the spinal cord were reported in this study, together with clinico-histopathologico-radiographic data.MethodsFrom January 2016 to December 2020, we conducted a retrospective study of five adults with primary DMG-H3K27a in the spinal cord, analyzing their clinical, pathohistological, and radiographic datasets from the first diagnosis to follow-up.ResultsAll five patients were diagnosed for the first time and were given full treatment. In three of the five patients, post-operative follow-up revealed tumor recurrence. The longest survival of the five patients was 45 months at the time of report submission, while the longest progression-free survival (PFS) following surgery was 20 months. Immunohistochemical studies showed the tumors featured aggressive behavior (grade 4) and were positive for the H3K27M mutation. The radiographic appearances were varied, but they were all initially mistaken as benign. DMG-H3K27a in the spinal cord was characterized by isointense/hyperintense on T1WI and isointense/hyperintense on T2WI, as well as cystic necrosis and peripheral spinal cord edema, as well as central canal enlargement and other types of enhancement.ConclusionThis is the first case report focusing on adult DMG-H3K27a of the pediatric-type diffuses high-grade gliomas in the spinal cord. In our cases, we discovered the following: 1) adults had a better prognosis with a longer PFS compared with prior pediatric reports; 2) despite aggressive behavior under the microscope, radiographic appearances of the tumors were less aggressive; and 3) adjuvant treatment, including TCM, may have played a role in the prognosis.
CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates
Authors: Lv Zheng , Feng Hua-Yi , Tao Wang , Li Hong-Zhao , Zhang Xu 
Published: December 2021

BackgroundsCD146 is highly expressed in various malignant tumors and associated with the poor prognosis. However, the role of CD146 in clear cell renal cell carcinoma (ccRCC) is still unknown. This study aimed to identify the role of CD146 in ccRCC by integrated bioinformatics analysis.MethodsCD146 mRNA expression and methylation data in ccRCC was examined using the TIMER, UALCAN, and MethSurv databases. CD146 expression in paraffin-embedded tissues (140 cancer samples and 140 paracancer tissues) from our cohort were examined by immunohistochemistry assay. The LinkedOmics database was used to study the signaling pathways related to CD146 expression. TIMER and TISIDB were used to analyze the correlations among CD146, CD146-coexpressed genes, tumor-infiltrating immune cells, and immunomodulators. The relationship between CD146 and drug response in renal cancer cell lines was analyzed by the CTRP and CCLE databases.ResultsThe mRNA and protein levels of CD146 were elevated in ccRCC tissues than that in paracancer tissues. The DNA methylation of CD146 in ccRCC tissues were lower than that in normal tissues. Importantly, high CD146 expression was associated with poor prognosis in patients with ccRCC. Furthermore, multivariate Cox regression analysis showed that CD146 was an independent prognostic factor in ccRCC. GO and KEGG pathway analyses indicated the co-expressed genes of CD146 were mainly related to a variety of immune-related pathways, including Th1 and Th2 cell differentiation, Th17 cell differentiation, and leukocyte transendothelial migration. Our data demonstrated that the expression and methylation status of CD146 were strongly correlated with immune infiltration levels, immunomodulators, and chemokines. Further, the sensitivity and resistance of renal cancer cell lines to some drugs were related to CD146 expression.ConclusionsOur study highlights the clinical significance of CD146 in ccRCC and provides novel insights into the immune function of CD146 in the tumor microenvironment.