bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Recurrence in Uterine Leiomyoma with Bizarre Nuclei: a Systematic Review and Meta-Analysis
Authors: Travaglino Antonio , Raffone Antonio , Santoro Angela , Raimondo Diego , Improda Francesco Paolo , Cariati Federica , De Marco Margot , Casadio Paolo , Seracchioli Renato , Zullo Fulvio , Insabato Luigi , Zannoni Gian Franco 
Published: November 2021

Abstract
Objective Leiomyoma with bizarre nuclei (LBN) is a variant of uterine leiomyoma, which has replaced the previous category of “atypical leiomyoma” and must be distinguished from smooth muscle tumors of uncertain malignant potential (STUMP). However, previously published series of “atypical leiomyoma” might have included both LBN and STUMP, due to the lack of strict diagnostic criteria. Based on such hypothesis, we aimed to define the risk of recurrence in LBN.
Study Design A systematic review and meta-analysis was performed by searching 4 electronic databases for all studies assessing the outcome of patients with “atypical leiomyoma” or LBN. The pooled absolute risk of recurrence was calculated. The included studies were subdivided into two subgroups based on the criteria used: “LBN + STUMP” or “LBN-only”.
Results Twelve studies with 433 patients were included. The pooled risk of recurrence was 5.5% overall. The funnel plot showed two cluster of studies which superimposed to the two subgroups. In the LBN + STUMP cluster/subgroup, the pooled risk of recurrence was 7.7%. In the LBN-only cluster/subgroup, the pooled risk of recurrence was 1.9%. Statistical heterogeneity was null in all analyses.
Conclusion Our results show a risk of recurrence of 1.9% for LBN; higher recurrence rates in older studies are likely due to the inclusion of STUMPs.
Body Size, Fatness and Skeletal Age in Female Youth Soccer
Players
Authors: Martinho Diogo V. , Coelho-e-Silva Manuel J. , Gonçalves Santos João , Oliveira Tomas G. , Minderico Cláudia S. , Seabra Andre , Valente-dos-Santos Joao , Sherar Lauren B. , Malina Robert M. 
Published: November 2021

AbstractGrowth and maturation are central concerns in the organization of training and
competitions in youth sports. This study examined maturity-associated variation
in body size and adiposity among adolescent girls participating in competitive
age group youth soccer. The sample included 441 players 10.08-16.73 years of
age. Stature and body mass were measured and body composition was predicted. The
Fels method was used to estimate skeletal age. Skeletally maturity status (late,
average or early maturing) was based on the difference between chronological and
skeletal age for each player. Mean stature approximated the 50th
percentiles of the general population in all competitive age groups, while mean
weight fluctuated between 50th and 75th percentiles. Age-
and maturity-specific means for estimated fat mass ranged between 18.0%
and 28.2%. The number of players classified as skeletally mature
increased with competitive age groups (under-13: 0%; under-15:
8%; under-17: 49%). In general, early maturing girls tended to
be heavier than their age group peers and especially when compared to late
maturing players.
Definitive Radiotherapy versus Surgery for the Treatment of Verrucous Carcinoma of the Larynx: A National Cancer Database Study
Authors: Kompelli Anvesh R. , Froehlich Michael H. , Morgan Patrick F. , Li Hong , Sharma Anand K. , Nathan Cherie-Ann O. , Neskey David M. 
Published: November 2021

AbstractIntroduction Traditionally, larger lesions of laryngeal verrucous carcinoma are treated with surgical excision, with definitive radiotherapy generally reserved for smaller lesions. However, data utilizing modern databases is limited.Objective The authors sought to assess, utilizing the National Cancer Database, whether overall survival for patients with laryngeal verrucous carcinoma was equivalent when treated with definitive radiotherapy versus definitive surgery.Methods A retrospective cohort study was conducted utilizing the National Cancer Database. All cases of laryngeal verrucous carcinoma within the National Cancer Database between 2006 and 2014 were reviewed. Patients with T1–T3 (American Joint Commission on Cancer 7th Edition) laryngeal verrucous carcinoma were included and stratified by treatment modality. Demographics, treatment, and survival data were analyzed.Results A total of 392 patients were included. Two hundred and fifty patients underwent surgery and 142 received radiotherapy. The two groups differed in age, transition of care, clinical T stage, and clinical stages. There was no significant difference in survival between T1–T3 lesions treated with surgery or radiotherapy (p = 0.32). Age, comorbidities, insurance status, and clinical T stage impacted overall hazard on multivariate analysis (p < 0.01). For patients treated with radiotherapy, age, insurance status, and clinical T stage were predictive of increased hazard.Conclusion Overall survival is equivalent for patients with clinical T1 and clinical T2 laryngeal verrucous carcinoma treated with primary radiotherapy versus primary surgery. Thus, radiotherapy should be considered as a non-inferior treatment modality for certain patients with laryngeal verrucous carcinoma.
Avaliação de métodos intramedulares com polimetilmetacrilato para fixação em lesões ósseas de extremidades
Authors: Moura Marcio , Sanches Diego Pereira , Pinto Álvaro Ferreira , Milano Sibele Sauzem , Villela Marcella Maria 
Published: November 2021

Resumo
Objetivo Avaliar o potencial melhor resultado funcional e controle álgico no tratamento de fraturas patológicas e fixações profiláticas tratadas com haste intramedular associada ao polimetilmetacrilato (PMMA) em comparação com o uso de haste intramedular em lesões tumorais em ossos longos.
Métodos De janeiro de 2012 a setembro de 2017, 38 pacientes com 42 lesões patológicas (fraturas ou iminência segundo os critérios de Mirels) foram tratados cirurgicamente. Dezesseis pacientes submetidos a fixação com haste intramedular bloqueada foram alocados ao grupo controle e 22 pacientes com lesões patológicas foram alocados para tratamento com haste intramedular associada ao PMMA. No pós-operatório, foi realizada a submissão dos pacientes ao escore da Musculoskeletal Tumor Society (MSTS, na sigla em inglês) e à avaliação radiográfica do tratamento realizado, assim como à avaliação de intercorrências e complicações relacionadas ao tratamento.
Resultados A avaliação através do questionário MSTS demonstrou melhor resultado funcional do grupo associado com PMMA quando comparado com o grupo controle, o qual obteve uma pontuação média de 16,375 em um máximo de 30 pontos (54,6%), enquanto o grupo em estudo com associação do PMMA obteve uma média de 22,36 pontos (74,5%). O procedimento mostrou-se seguro, taxas de complicações e gravidade semelhantes e sem diferença estatística quando comparado com o tratamento padrão.
Conclusão A estabilização de lesões tumorais com fixação associada ao PMMA demonstrou reabilitação precoce e melhora na qualidade de vida, permitindo rápida recuperação funcional. A utilização do PMMA apresenta vantagens como diminuição do sangramento e da necrose tumoral e maior estabilidade mecânica.
O impacto do envolvimento do residente nos resultados dos pacientes na revisão da artroplastia total do quadril
Authors: Alexander Bradley , Sowers Mackenzie , Jacob Roshan , McGwin Gerald , Maffulli Nicola , Naranje Sameer 
Published: November 2021

Resumo
Objetivo O objetivo do presente estudo foi determinar a influência do envolvimento dos residentes nas taxas de complicações agudas na revisão da artroplastia total do quadril (ATQ).
Métodos Utilizando o banco de dados do American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP, na sigla em inglês), foram identificadas 1.743 revisões de ATQs entre 2008 e 2012; 949 delas envolveram um médico residente. Foram analisadas informações demográficas, incluindo gênero e raça, comorbidades, incluindo doenças pulmonares, doenças cardíacas e diabetes, tempo de permanência e complicações agudas pós-operatórias no prazo de 30 dias.
Resultados O envolvimento dos residentes não foi associado a um aumento significativo no risco de complicações agudas. O tempo de operação total demonstrou associação estatisticamente significativa com o envolvimento de um residente (161,35 minutos com residente presente, 135,07 minutos sem residente; p < 0,001). Não houve evidência de que o envolvimento do residente tenha sido associado a um maior tempo de internação hospitalar (5,61 dias com residente presente, 5,22 dias sem residente; p = 0,46).
Conclusão O envolvimento de um residente ortopédico durante a revisão da ATQ não parece aumentar as taxas de complicações pós-operatórias de curto prazo, apesar de um aumento significativo nos tempos operacionais.
Heuristic Evaluation of a Top-Rated Diabetes Self-Management App
Authors: Harrington Linda , Parker Cheryl , Ulanday Kathleen , Harrington Craig 
Published: November 2021

AbstractObjective The purpose of this study was to evaluate the usability of a top-rated diabetes app. Such apps are intended to markedly support the achievement of optimal health and financial outcomes by providing patients with substantive and continual support for self-management of their disease between periodic clinician visits. Poor usability can deter use which is especially concerning in patients with diabetes due to prevalence of the disease and impact of self-management on long-term prognosis.Methods A diabetes app was selected due to the prevalence and seriousness of the disease. A heuristic evaluation was then performed to collect and analyze data on the usability of the app based on Nielsen's heuristics. Pareto analysis was used to illustrate the contribution of each type of heuristic violation, augmented by a stacked bar chart illuminating associated severity.Results There were 51 heuristic violations on the opening screen, violating 6 of Nielsen's 10 heuristics. Pareto analysis revealed 29 (57%) of the heuristic violations involved a match between system and real world and 8 (16%) aesthetic and minimalist design. Severity ratings ranged from 1.0 to 4.0 (mean: 3.01) with 80% comprising a major usability problem and 6% a usability catastrophe.Conclusion Studies show that people with diabetes are more likely to receive greater benefit from a diabetes app if they are easy to use. The number and severity of heuristic violations in this study suggest that the commercialization of mobile health apps may play a factor in bypassing experts in clinical informatics during the design phase of development. Usability and associated benefits received from mobile health apps can be enhanced by debugging the user interface of identified heuristic violations during design. Waiting to correct ongoing usability issues while apps are in production can result in patients disengaging from use of digital health tools engendering poorer outcomes.
Labile soil carbon and nitrogen fractions under short and long-term integrated crop–livestock agroecosystems
Authors: Dhaliwal Jashanjeet Kaur , Laxmisagra Sagar Kavya , Chellappa Jemila , Sekaran Udayakumar , Kumar Sandeep 
Published: November 2021

Context Labile soil C and N fractions are strongly influenced by agricultural management practices. Aims This study was conducted on three long-term (≥30 years) on-farm sites (sites 1–3), and one short-term (3 years) experimental site (site 4) to evaluate the impacts of integrated crop–livestock system (ICLS) on labile C and N fractions and β-glucosidase enzyme activity for the 0–5 cm soil depth. Methods Long-term management systems (ICLS, corn (Zea mays L.)/grazing–soybean (Glycine max (L.) Merr.)/grazing–cover crop/grazing), control (CNT, corn–soybean with no cover crop and no grazing), and a grazed pasture (GP) at sites 1–3 were compared. At site 4, the treatments included: ICLS (corn/grazing–soybean/grazing–oat (Avena sativa L.)–cover crop/grazing); CC (corn–soybean–oat–cover crop with no grazing); CNT (corn–soybean–oat–fallow with no grazing); and GP. Key results ICLS had higher hot water extractable organic carbon (HWC), cold water extractable organic carbon (CWC), microbial biomass carbon (MBC), microbial biomass nitrogen (MBN), potential carbon mineralisation (PCM) and potassium permanganate oxidisable carbon (POXC) than CNT under long-term management system. Long-term ICLS also enhanced β-glucosidase activity compared to CNT. ICLS had 72%, 214% and 60% higher glucosidase activity than the CNT at sites 1, 2 and 3, respectively. However, the C and N fractions and β-glucosidase activity were not affected by short-term ICLS (site 4). GP always had higher C and N fractions than ICLS and the CNT. There was a significantly positive relationship between SOC and labile C and N fractions, except POXC. Conclusions and implications Long-term inclusion of cover crops and livestock grazing in corn–soybean system was effective in enhancing labile soil C and N fractions.
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation
Authors: Erdélyi Katalin , Ditrói Tamás , Johansson Henrik J. , Czikora Ágnes , Balog Noémi , Silwal-Pandit Laxmi , Ida Tomoaki , Olasz Judit , Hajdú Dorottya , Mátrai Zoltán , Csuka Orsolya , Uchida Koji , Tóvári József , Engebraten Olav , Akaike Takaaki , Børresen Dale Anne-Lise , Kásler Miklós , Lehtiö Janne , Nagy Péter 
Published: November 2021

Significance
Basal-like breast cancers (BLBC) have poor prognosis. Here, we present evidence that reprogrammed transsulfuration is a hallmark of BLBC. Human BLBC tumors exhibit elevated levels of cystathione β-synthetase (CBS) but diminished expressions of oxidative Cys-catabolizing enzymes supporting a Cys-addicted phenotype. We demonstrated that in BLBC cells, CBS plays a role in cellular proliferation and invasiveness, HIF1-α activation under hypoxia, and protection against oxidative stress and CySSCy deprivation–induced ferroptosis. Tumor progression and angiogenesis was impaired in shCBS xenograft tumors, which had larger intratumoral necrotic areas. Mechanistic analyses largely based on sulfur metabolome and proteomics data revealed that realigned Cys persulfidation is a determining factor in this Cys-addicted phenotype of BLBC tumors, which holds promise for drug development.
Revisiting the theory behind AFM indentation procedures. Exploring the physical significance of fundamental equations
Authors: Kontomaris Stylianos-Vasileios , Malamou Anna 
Published: November 2021

Abstract
Fundamental contact mechanics models concerning the interaction of an axisymmetric indenter and an elastic half-space are usually employed in atomic force microscopy (AFM) indentation methods. In this paper, a simplified ‘equivalent’ physical system is used to correlate basic magnitudes such as the applied force on an elastic half space, the Young’s modulus, the contact radius and the indentation depth. More specifically, the equations correlating the above magnitudes are derived using fundamental physics instead of the typical rigorous mathematical process with a small error. In addition, the relation between a force-indentation curve and the indenter’s shape is also presented in detail in order to help students and non-specialists in contact mechanics to obtain a strong background to the AFM indentation theory.
Angular distributions in the double ionization of argon by fast electron impact
Authors: Herbadji A , Kada I , Mansouri A , Cappello C Dal 
Published: November 2021

Abstract
In this paper, a model describing the two electrons ejected by distorted waves is applied to the study of the double ionization of argon by fast electrons (∼5500 eV). The correlation is also partially taken into account both in the final state and in the initial state. The results obtained by our model as well as by other models that are also based on the first Born approximation are compared with the available experimental data.
Kinetic Monte Carlo method applied to micrometric particle detachment mechanisms by aerodynamic forces
Authors: Villagrán Olivares Marcela C , Benito Jesica G , Uñac Rodolfo O , Vidales Ana M 
Published: November 2021

Abstract
The formulation of a kinetic Monte Carlo simulation to account for the different possible mechanisms present in the problem of resuspension of aerosol particles is addressed as an extension of a former model Benito et al (2016 J. Aerosol Sci.
100 26–37). The re-entrainment of micrometer particles to airflow when detached from a surface by aerodynamic forces is modeled using the similitude of the problem with the desorption process from heterogeneous surfaces. Depending on the relative role of the intervening forces, three main mechanisms for movement initiation can be present: rolling, sliding and lifting-off. Three different transition probabilities are defined for each mechanism and the corresponding transition rates calculated for the kinetic process to be simulated. The decisive factor for the development of the model is to set an appropriate dynamical hierarchy to simulate correctly the evolution of the transition rates as the airflow velocity increases, reflecting the stochastic nature of the process, not always fully captured by other Monte Carlo approaches. The model is applied to spherical and elongated particles on a flat surface, reproducing qualitatively well the experimental trends found by other authors for the case of particles with different shapes. It is also demonstrated that, for elongated particles, the main mechanism assisting the detachment is not rolling but sliding, underscoring the need for an adequate choice of the particles shape and detachment mechanism when looking for the critical conditions for particle removal from surfaces.
Two-step gradient-assisted phase-shifting demodulation algorithm for fast 3D reconstruction
Authors: Wu Yanxue , Wu Gaoxu , Yang Shichao , Yang Tian , Liu Fei 
Published: November 2021

Abstract
The conventional multi-frequency heterodyne method is one of the most widely used methods in non-contact 3D measurement. However, it needs to project different phase-shifting patterns with different frequencies, so a large number of patterns are required. For most conventional methods, the fringe period number of the projected patterns is usually small due to its limited noise tolerance, though a larger fringe period number always means higher accuracy. We propose a two-step phase-shifting demodulation algorithm based on an intensitygradient. In this method, only two patterns for each frequency are required. With the intensity gradient of the two patterns, we obtain the wrapped phase of each frequency. Next, the absolute phase is retrieved from the three wrapped phases with the heterodyne algorithm. Because only two patterns are required for each frequency, the proposed method is more robust and has higher measuring speed compared with the traditional three-frequency four-step heterodyne method. Simulations and experiments prove the feasibility and effectiveness of the method, and demonstrate that the proposed method extends the noise tolerance and achieves highprecision with only half of the patterns required by the traditional three-frequency four-step method.
MiniCarb: a passive, occultation-viewing, 6U CubeSat for observations of CO2, CH4, and H2O
Authors: Wilson Emily L , Riot Vincent J , DiGregorio A J , Ramu Guru , Cleveland Paul , Simms Lance M , Carter Darrell , Bruner Bill , Young Jennifer , Villanueva Geronimo 
Published: November 2021

Abstract
We present the final design, environmental testing, and launch history of MiniCarb, a 6U CubeSat developed through a partnership between NASA Goddard Space Flight Center and Lawrence Livermore National Laboratory. MiniCarb’s science payload, developed at Goddard, was an occultation-viewing, passive laser heterodyne radiometer for observing methane, carbon dioxide, and water vapor in Earth’s atmosphere at ∼1.6 µm s−1. MiniCarb’s satellite, developed at Livermore, implemented their CubeSat Next Generation Bus plug-and-play architecture to produce a modular platform that could be tailored to a range of science payloads. Following the launch on 5 December 2019, MiniCarb traveled to the International Space Station and was set into orbit on 1 February 2020 via Northrop Grumman’s Cygnus capsule which deployed MiniCarb with tipoff rotation of about 20° s−1 (significantly higher than the typical rate of 3° s−1 from prior CubeSats), from which the attitude control system was unable to recover resulting in a loss of power. In spite of this early failure, MiniCarb had many successes including rigorous environmental testing, successful deployment of its solar panels, and a successful test of the radio and communication through the Iridium network. This prior work and enticing cost (approximately $2 M for the satellite and $250 K for the payload) makes MiniCarb an ideal candidate for a low-cost and rapid rebuild as a single orbiter or constellation to globally observe key greenhouse gases.
The model of synchronization between internal reconnections and edge-localized modes
Authors: Bulanin V V , Kurskiev G S , Solokha V V , Yashin A Yu , Zhiltsov N S 
Published: November 2021

Abstract
A new model for interaction between the internal reconnections caused by sawtooth and the edge-localized modes (ELM) was presented. The experimental evidence of the coupling between sawtooth crash and ELM events were observed in the Globus-M and Globus-M2 tokamaks. The numerical analysis of magnetic equilibrium showed that internal reconnections can induce the excess current density near the separatrix during the several hundreds of μs. The excess current destabilizes the peeling-ballooning (PB) instability. The PB stability analysis showed that the penetration depth of the induced current should be in the range of ψ
norm = 0.8–0.95 to trigger the instability.
FSI and non-FSI studies on a functionally graded temperature-responsive hydrogel bilayer in a micro-channel
Authors: Mazaheri Hashem , Khodabandehloo Amin 
Published: November 2021

Abstract
Taking into account both fluid-structure interaction (FSI) and non-FSI simulations, the deformation of a bilayer is investigated in this paper. The bilayer, which is utilized in a micro-channel, consists of a Functionally-graded (FG) temperature-responsive hydrogel layer and an incompressible elastomeric one. Allocating two different positions to the elastomeric layer, we make two different bilayers where in one of them, the elastomer layer is located on the left (LSE) and on the right (RSE) in another one. Also, to see the effect of grading, two bilayers with homogenous hydrogel layers with different amounts of cross-linking density are considered. For FG cases in which the hydrogel layer’s properties vary through thickness direction, both ascending and descending arrangements are analyzed. Each simulation, whether it is FSI or non-FSI, is conducted utilizing three software. FLUENT for fluid domain examinations, ABAQUS for finite element method analysis, and MpCCI to couple two aforementioned simulation domains. By extracting and comparing both simulations results, it is observed that the influence of the fluid flow is very significant and should not be ignored. Moreover, it is discovered that the fluid flow affects more the RSE configuration and also the bilayers with lower amounts of cross-linking density. Finally, we investigate how some parameters, such as inlet pressure, can affect the behavior of the bilayer.