bluuebunny/crossref_metadata_2025_split huggingface dataset:
Status Al-Quran Digital dari Perspektif Fiqh
Authors: Mohamed Khairul Anuar 
Published: February 2021

The working paper entitles ''The status of Quranic Digital from Fiqh Perspective''. There is no doubt taht in recent years, IT has been widely used in all aspect especially in our daily life. Our religion also accepts IT as one of the way to preach and it also has been widely used in Islamic world. One of the proof was the invention of Quranic Digital. Islamic technocrats have invented the Digital Quran for Muslim to make good use of it but also to help us to draw closer to Allah. The objective of this paper is to identify and explain about the fiqh's problems between Digital Quran and physical Quran such as Mushaf. This explanation hopefully can help Muslims to have confidence when using the Quranic Digital especially in the mainstream. A research has been conducted to study about the fiqh's problem in Quranic Digital and the author found out that the Quranic Digital can be touch even without wudhu' or during period (Haidh) because of it was not physically written like Mushaf and the words was stored in the device with other equipment.
Pemanfaatan Digital Marketing Dalam E-Commerce Di Masa Pandemi Covid-19 Pada Majelis Talim Hidayatul Mubtadiin
Authors: Mariskhana Kartika , Suharyanti Nining , Suparni Endang , Syahlani Achmad , Anggarini Desy Tri 
Published: February 2021

Meningkatnya kasus positif virus corona Covid-19 di Jakarta kembali meningkat tajam dan sejak PSBB transisi 4 Juni sampai dengan 2 Juli jumlah kasus baru yang ditemukan 6.748 kasus. Selain itu Pemprov DKI Jakarta pun selalu memperhatikan angka presentase yang muncul, sebagai upaya antisipasi dan mengendalikan perkembangan dari Covid-19. Untuk itu media digital marketing adalah media yang efektif dalam era covid 19. Pelatihan Digital marketing dalam E-commerce pada Majelis Taklim Hidayatul Mubtadiin ini diharapkan dapat menjadi kontribusi yang bermanfaat untuk peningkatan kualitas dan kemampuan dalam pemasaran digital marketing lebih efektif. Pelatihan dilakukan dengan metode penyampaian teori dan praktek secara langsung. Pada akhir pelatihan, peserta menyatakan puas dengan angka 95 % dari hasil kuesioner yang disebarkan kepada mereka. Hampir rata-rata menyatakan bahwa materi pelatihan sesuai dengan kebutuhan mereka, karena dapat menunjang pekerjaan. Selanjutnya mereka juga mengatakan bahwa materi yang diberikan lengkap dan mudah dipahami, banyak yang menyatakan demikian, yakni sebesar 95,67%.
Self-Efficacy Among Indonesian Chronic Liver Disease Patients
Authors: Siburian Apriliani , Chang Ching Fen 
Published: February 2021

Chronic Liver Diseases are among the most extensive diseases globally and are related to significant morbidity and mortality. Although physical well-being has long been the primary goal of medical care, as chronic disease becomes more prevalent in developed countries, there has been a greater focus on patients' emotional and social well-being. This study aimed to describe the self-efficacy among chronic liver disease patients in North Sumatra, Indonesia. This study uses a cross-sectional design. The study assessed 102 chronic liver disease patients from two hospitals using the Chronic Disease Self-Efficacy Scales Indonesian version. The participants had moderate self-efficacy (58.8%), followed by high self-efficacy (38.2%). The majority of the patients in this study had moderate self-efficacy because many individuals with chronic liver disease suffer chronic fatigue, abdominal pain and swelling, itchy skin, nausea or vomiting, loss of appetite, and other symptoms that affect self-efficacy. Health professionals should strengthen patients' self-efficacy by engaging in positive activities and enhancing their coping skills
The Festivalisation of Edinburgh: constructing its governance
Authors: Hague Cliff 
Published: February 2021

Edinburgh has forged a global brand as the Festival City. The international cultural festival began in 1947, but was contentious in the city for a long period. In the 1990s a wider array of festivals were promoted by the local council. Then in a third stage, from the mid-1990s the festivals became anchored in the city's tourism offer, and achieved year upon year of growth, to widespread acclaim by the cultural and tourism industries and local politicians. A shared corporate culture was built in which national and local political and cultural bodies planned and delivered change through stakeholder partnerships. Private consultants are found to have played an important role in framing policy and prioritising the economic benefits of the festivals. The paper analyses these governance relationships, as a form of growth coalition. However, it sets the local actions in the context of international economic and political changes, noting also how the 2008 financial and economic crisis impacted on Edinburgh, and the subsequent period of austerity imposed on the local council. The result has been the festivalisation of the city, through intensification and extension of the festivals and associated commercial cultural events, and the commodification of public spaces. Those driving this process paid little attention to concerns about the impacts on the local and wider environment, or the capacity of parts of the city to absorb visitor numbers. The paper is the first part of a double article. The second part, to be published in a later issue, looks at why and how the hegemonic governance structures were challenged by civil society, and how the Covid-19 crisis that began in 2020 impacted on the growth trajectory.
Atributos de liderazgo en Instagram durante las elecciones presidenciales en Argentina 2019
Authors: García-Beaudoux Virginia , Berrocal-Gonzalo Salomé , D'Adamo Orlando 
Published: February 2021

La investigación analiza los contenidos que 32 candidatos y candidatas publicaron en sus cuentas de Instagram durante el mes previo a la fecha de las elecciones presidenciales en Argentina de 2019. Se utilizó el método de análisis de contenido, con el objetivo de evaluar dos variables: tipo de información publicada, y estilo de liderazgo comunicado. Los principales resultados indican que privilegiaron el contenido propiamente político más que el politainment, y la proyección de habilidades duras de liderazgo más que blandas. Por su parte, los usuarios de Instagram manifiestan su preferencia por las publicaciones en las que se comunican habilidades blandas de liderazgo, sobre todo cuando se trata de las publicaciones de las candidatas
Estudio del comportamiento de consumo del surfista español. Una aproximación desde la perspectiva profesional
Authors: Sanz-Marcos Paloma , Jiménez-Marín Gloria 
Published: February 2021

Este artículo realiza un análisis de la práctica y consumo del surf en España con objeto de profundizar en el estudio del surfista español desde una perspectiva de consumo. A través de una metodología de enfoque cualitativo basada en la realización de un panel de expertos que cuenta con los representantes de las ocho marcas más representativas del surf español y la celebración de cuatro focus groups integrados por surfistas españoles, se persigue conocer si tanto la práctica como el consumo de esta actividad conlleva algún tipo de implicación social en su condición como espacio de identificación colectiva. Los resultados indican que, si bien se trata de un deporte plenamente desarrollado socialmente, no existen indicios de que su práctica motive o fortalezca vínculos sociales entre los surfistas españoles.
Recursos periodísticos en la construcción del relato sobre las consecuencias de la crisis económica en la población
Authors: Gómez López Concepción , García Soidán Pilar 
Published: February 2021

La presente investigación estudia el uso de algunas herramientas, en el discurso elaborado por la prensa, para narrar el efecto de la primera crisis del siglo XXI en la población española. Este objetivo se ha desarrollado a partir del corpus creado con las piezas informativas publicadas en los periódicos de mayor influencia en una ciudad española (Vigo), de importancia estratégica para la economía de su entorno, cuyo modelo sería extrapolable a otras urbes de similares características. Para delimitar el período de estudio (de septiembre de 2009 a julio de 2011), se tomaron como referencia dos hechos que tuvieron especial relevancia en la crisis económica que vivió la región considerada. Dentro de este marco temporal, se construyó la muestra a partir de las piezas informativas publicadas en las 23 semanas seleccionadas para esta investigación, que respondían a los criterios establecidos para la búsqueda. Con los datos resultantes, se realizó un análisis exploratorio para determinar la utilización de los siguientes recursos: presencia en portada, género periodístico y acompañamiento de fotografías u otros elementos gráficos.
The Syenite–Carbonatite Complex of Ihouhaouene (Western Hoggar, Algeria): Interplay Between Alkaline Magma Differentiation and Hybridization of Cumulus Crystal Mushes
Authors: Djeddi A. , Parat F. , Bodinier J.-L. , Ouzegane K. , Dautria J.-M. 
Published: February 2021

The 2 Ga-old Ihouhaouene alkaline complex (Western Hoggar, Algeria) is among the oldest known carbonatite occurrences on Earth. The carbonatites are calciocarbonatites hosted by syenites, the predominant rock type in the complex. Both rock types are characterized by medium-grained to pegmatitic textures and contain clinopyroxene, apatite, and wollastonite, associated with K-feldspar in syenites and a groundmass of calcite in carbonatites. The rock suite shows a continuous range of compositions from 57–65 wt.% SiO2and 0.1–0.4 wt.% CO2in red syenites to 52–58 wt.% SiO2and 0.1–6.5 wt.% CO2in white syenites, 20–35 wt.% SiO2and 11–24 wt.% CO2in Si-rich carbonatites (&gt;10% silicate minerals), and &lt;20 wt.% SiO2and 24–36 wt.% CO2in Si-poor carbonatites (&lt;5% silicate minerals). Calculation of mineral equilibrium melts reveals that apatite and clinopyroxene are in disequilibrium with each other and were most likely crystallized from different parental magmas before being assembled in the studied rocks. They are subtle in the red syenites, whereas the white syenites and the Si-rich carbonatites bear evidence for parental magmas of highly contrasted compositions. Apatite was equilibrated with LREE-enriched (Ce/Lu = 1,690–6,182) carbonate melts, also characterized by elevated Nb/Ta ratio (&gt;50), whereas clinopyroxene was precipitated from silicate liquids characterized by lower LREE/HREE (Ce/Lu = 49–234) and variable Nb/Ta ratios (Nb/Ta = 2–30). The Si-poor carbonatites resemble the Si-rich carbonatites and the white syenites with elevated REE contents in apatite equilibrium melts compared to clinopyroxene. However, apatite equilibrium melt in Si-poor carbonatite shows a majority of subchondritic values (Nb/Ta&lt;10) and clinopyroxene has chondritic-to-superchondritic values (Nb/Ta = 15–50). Although paradoxical at first sight, this Nb-Ta signature may simply reflect the segregation of the carbonatite from highly evolved silicate melts characterized by extremely low Nb/Ta values. Altogether, our results suggest an evolutionary scheme whereby slow cooling of a silico-carbonated mantle melt resulted in the segregation of both cumulus minerals and immiscible silicate and carbonate melt fractions, resulting in the overall differentiation of the complex. This process was however counterbalanced by intermingling of partially crystallized melt fractions, which resulted in the formation of hybrid alkaline cumulates composed of disequilibrium cumulus phases and variable proportions of carbonate or K-feldspar.
The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population
Authors: Wang Biyan , Zhang Xiaoyu , Liu Di , Zhang Jie , Cao Mingyang , Tian Xin , Maranga Isinta Elijah , Meng Xiaoni , Tian Qiuyue , Tian Feifei , Cao Weijie , Wang Wei , Song Manshu , Wang Youxin 
Published: February 2021

Background: The causal association of C-reactive protein (CRP) and fibrinogen on intracerebral hemorrhage (ICH) remains uncertain. We investigated the causal associations of CRP and fibrinogen with ICH using two-sample Mendelian randomization.Method: We used single-nucleotide polymorphisms associated with CRP and fibrinogen as instrumental variables. The summary data on ICH were obtained from the International Stroke Genetics Consortium (1,545 cases and 1,481 controls). Two-sample Mendelian randomization estimates were performed to assess with inverse-variance weighted and sensitive analyses methods including the weighted median, the penalized weighted median, pleiotropy residual sum and outlier (MR-PRESSO) approaches. MR-Egger regression was used to explore the pleiotropy.Results: The MR analyses indicated that genetically predicted CRP concentration was not associated with ICH, with an odds ratio (OR) of 1.263 (95% CI = 0.935–1.704, p = 0.127). Besides, genetically predicted fibrinogen concentration was not associated with an increased risk of ICH, with an OR of 0.879 (95% CI = 0.060–18.281; p = 0.933). No evidence of pleiotropic bias was detected by MR-Egger. The findings were overall robust in sensitivity analyses.Conclusions: Our findings did not support that CRP and fibrinogen are causally associated with the risk of ICH.
Hepatocyte Endoplasmic Reticulum Stress Inhibits Hepatitis B Virus Secretion and Delays Intracellular Hepatitis B Virus Clearance After Entecavir Treatment
Authors: Chen Huan , Mu Maoyuan , Liu Qichuan , Hu Han , Tian Caiyun , Zhang Guoyuan , Li Ying , Yang Fangwan , Lin Shide 
Published: February 2021

Background: The aim of this study was to explore the effects of endoplasmic reticulum (ER) stress on hepatitis B virus (HBV) replication and the antiviral effect of entecavir (ETV).Methods: Thapsigargin (TG) and stearic acid (SA) were used to induce ER stress in HepG2.2.15 cells and HepAD38 cells that contained an integrated HBV genome, while ETV was used to inhibit HBV replication. The expression levels of glucose-regulated protein 78 (GRP78) and phosphorylated eukaryotic translation initiation factor 2 subunit alpha (p-eIF2α) were measured by western blotting. Intracellular HBV DNA was determined by qPCR; HBsAg by western blotting; HBV RNA by real-time RT-qPCR; HBsAg and HBeAg in supernatants by enzyme-linked immunosorbent assay (ELISA); and HBV DNA in supernatants by qPCR.Results: TG and SA induced ER stress in HepG2.2.15 cells and HepAD38 cells from 12 to 48 h post treatment. However, 4-phenylbutyric acid (PBA) partly alleviated the TG-induced ER stress. Moreover, TG inhibited HBsAg, HBeAg, and HBV DNA secretion from 12 to 48 h, while different concentrations of SA inhibited HBsAg and HBV DNA secretion at 48 h. TG promoted intracellular HBV DNA and HBsAg accumulation and the transcription of the HBV 3.5-kb mRNA and S mRNA. PBA treatment restored the secretion of HBsAg and HBV DNA. Finally, ER stress accelerated extracellular HBV DNA clearance but delayed intracellular HBV DNA clearance after ETV treatment.Conclusions: Hepatocyte ER stress promoted intracellular HBV DNA and HBsAg accumulation by inhibiting their secretion. Our study also suggested that hepatocyte ER stress delayed intracellular HBV DNA clearance after ETV treatment.
Exploring the Prevalence and Factors Associated With Fatigue in Axial Spondyloarthritis in an Asian Cohort in Singapore
Authors: Lim Wei Ze , Fong Warren , Kwan Yu Heng , Leung Ying Ying 
Published: February 2021

Aim:To evaluate the prevalence of fatigue and the factors associated with fatigue among patients with axial spondyloarthritis (axSpA) within an Asian population.Method:We used the baseline data from a clinic registry in a tertiary referral center. All patients fulfilled the 2009 Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA. Severe fatigue was defined as Bath Ankylosing Spondylitis Disease Activity Index-fatigue (BASDAI-fatigue) ≥5/10 and vitality domain of Short Form-36 Health Survey (SF-36 VT) ≤10th percentile of the general population.Results:We included 262 consecutive patients with axSpA (79% men, 82.4% Chinese). The mean (standard deviation, SD) age and duration of disease were 41.7 (13.7) and 10.1 (8.3) years, respectively. 145 (55.3%) and 52 (31.1%) patients reported severe fatigue by the BASDAI-fatigue and SF-36 VT criteria, respectively. Patients with severe fatigue had worse scores across all disease activity assessments and disease impact measures compared to those without severe fatigue. Using principal component analyses, disease activity and impact were associated with BASDAI-fatigue, while disease activity and impact, and disease chronicity were associated with SF-36 VT. In the univariable analyses, all disease activity assessments and disease impact measures correlated with both BASDAI-fatigue and SF-36 VT. In the multivariable analyses, BASDAI-axial pain, BASFI, BAS-G, and ethnicity were associated with BASDAI-fatigue, while ASQoL and BASDAI-morning stiffness were associated with SF-36 VT.Conclusion:Fatigue is prevalent amongst patients with axSpA in Asia and is associated with disease activity, disease impact as well as patient related factors.
Elevated Creatinine Kinase in Peripheral Neuropathy Is Associated With Muscle Cramping
Authors: Jordan Allison , Nagaraj Arun , Hoyle J. Chad , Stino Amro Maher , Arnold W. David , Elsheikh Bakri 
Published: February 2021

Introduction: Serum Creatinine Kinase (CK) is a non-specific marker of muscle damage. There has been limited investigation of the association between peripheral neuropathy and CK elevation (hyperCKemia).Methods: We performed a chart review to investigate the CK level in peripheral neuropathies. Demographics, clinical history, physical exam, electrodiagnostic data, CK level, statin use, etiology of neuropathy, and concomitant neuromuscular disorders were recorded. HyperCKemia was defined using our laboratory cutoff values of &gt;180 U/L (women) and &gt;220 U/L (men).Results: We identified 450 patients with peripheral neuropathy who had CK testing, 92 (20.4%) of whom had hyperCKemia. Sixty-one of those patients (13.5% of the total figure) had a concomitant etiology that could explain the CK elevation. Thirty-one patients (6.9%) had no other identifiable etiology for their hyperCKemia beyond the neuropathy. The average CK level in the latter cohort with hyperCKemia was 376 U/L (women: 312 U/L; men: 444 U/L). The frequency of cramping was greater in patients with elevated vs. normal CK (p &lt; 0.0001).Discussion: HyperCKemia can occur in patients with peripheral neuropathy and appears to associate with cramping.
Dietary Diversity and Its Contribution in the Etiology of Maternal Anemia in Conflict Hit Mount Cameroon Area: A Cross-Sectional Study
Authors: Jugha Vanessa Tita , Anchang-Kimbi Judith Kuoh , Anchang Juliana Adjem , Mbeng Kennedy Aminde , Kimbi Helen Kuokuo 
Published: February 2021

Background: In the Mount Cameroon area, maternal anemia remains a major public health concern. We hypothesized that nutrient inadequacy may account for the level of anemia in pregnancy. Thus, this study examined the relative effect of dietary diversity on maternal anemia in the study area.Methods: A total of 1,014 consenting pregnant women were enrolled in this cross-sectional study. Information on socio-demographic, antenatal characteristics, malaria and anemia control measures were documented. Dietary diversity (DD) was evaluated using the 24-h recall method and hemoglobin (Hb) levels (g/dl) measured using a portable Hb meter. Malaria parasitaemia was diagnosed by blood microscopy. Anemia status was trimester specific. Logistic regression analysis was used determine predictors of maternal anemia.Results: Among the pregnant women enrolled, the mean DD score was 3.5±0.8 SD and only 10.4% had adequate dietary diversity. Anemia prevalence was 40.9%. Majority of the women consumed starchy staples (99.3%) while least consumed foods were dairy (4.5%), eggs (8.3%), fruits and vegetable (vitamin A-rich) (8.6%). A significant lower prevalence of anemia was associated with intake of dairy (P &lt; 0.001), animal protein (P = 0.006), vitamin A-rich fruits and vegetables (P &lt; 0.001). Furthermore, mean Hb levels were higher (P &lt; 0.001) among women with diverse diets (12.39 ± 1.34) than in those with less diverse diets (10.85 ± 1.33). Predictors of anemia were as follows: study setting [Odd Ratio (OR) = 1.4, 95% CI: 1.07-1.94], occupation (OR = 1.9, 95% CI: 1.16-3.43), number of clinic visits (OR = 1.9, 95% CI: 1.27-2.91), trimester of pregnancy (OR = 3.2, 95% CI: 1.45-7.38), malaria parasitaemia (OR = 1.8, 95% CI: 1.33-2.68), out of home eating (OR = 1.4, 95% CI: 1.03-2.13), and DD (OR = 9.8, 95% CI: 4.56-20.80). The attributable risk of anemia due to dietary diversity was 82.9%.Conclusion: In the study area, DD is a major risk factor for maternal anemia. This finding underscores the importance of content specific nutrition education during clinic visits to improve intake of protein and iron-rich food in anemia prevention.
Artificial Intelligence in Decision-Making for Colorectal Cancer Treatment Strategy: An Observational Study of Implementing Watson for Oncology in a 250-Case Cohort
Authors: Aikemu Batuer , Xue Pei , Hong Hiju , Jia Hongtao , Wang Chenxing , Li Shuchun , Huang Ling , Ding Xiaoyi , Zhang Huan , Cai Gang , Lu Aiguo , Xie Li , Li Hao , Zheng Minhua , Sun Jing 
Published: February 2021

BackgroundPersonalized and novel evidence-based clinical treatment strategy consulting for colorectal cancer has been available through various artificial intelligence (AI) supporting systems such as Watson for Oncology (WFO) from IBM. However, the potential effects of this supporting tool in cancer care have not been thoroughly explored in real-world studies. This research aims to investigate the concordance between treatment recommendations for colorectal cancer patients made by WFO and a multidisciplinary team (MDT) at a major comprehensive gastrointestinal cancer center.MethodsIn this prospective study, both WFO and the blinded MDT’s treatment recommendations were provided concurrently for enrolled colorectal cancers of stages II to IV between March 2017 and January 2018 at Shanghai Minimally Invasive Surgery Center. Concordance was achieved if the cancer team’s decisions were listed in the “recommended” or “for consideration” classification in WFO. A review was carried out after 100 cases for all non-concordant patients to explain the inconsistency, and corresponding feedback was given to WFO’s database. The concordance of the subsequent cases was analyzed to evaluate both the performance and learning ability of WFO.ResultsOverall, 250 patients met the inclusion criteria and were recruited in the study. Eighty-one were diagnosed with colon cancer and 189 with rectal cancer. The concordances for colon cancer, rectal cancer, or overall were all 91%. The overall rates were 83, 94, and 88% in subgroups of stages II, III, and IV. When categorized by treatment strategy, concordances were 97, 93, 89, 87, and 100% for neoadjuvant, surgery, adjuvant, first line, and second line treatment groups, respectively. After analyzing the main factors causing discordance, relative updates were made in the database accordingly, which led to the concordance curve rising in most groups compared with the initial rates.ConclusionClinical recommendations made by WFO and the cancer team were highly matched for colorectal cancer. Patient age, cancer stage, and the consideration of previous therapy details had a significant influence on concordance. Addressing these perspectives will facilitate the use of the cancer decision-support systems to help oncologists achieve the promise of precision medicine.