bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Reliability Estimation of a CMTSC Considering Dynamic Clamping Force
Authors: Zhai Z P , Zhang B Y , Gong Y Z , Zhang H J , Cheng H Y , Ren Y Y 
Published: February 2021

Abstract
The reliability of coil type manual three-jaw self-centering chucks (CMTSCs) of machine tools impacts significantly on reliability and safe operations of machine tools. This paper carries out a detailed reliability estimation of a CMTSC, in which the dynamic clamping force of the chuck is considered. Initially, a mathematical model of dynamic clamping force of the CMTSC is established after analyzing forces of key components of the CMTSC. Subsequently, Taking the dynamic clamping force of the jaw as the generalized stress and the minimum clamping force specified by the national standard as the generalized strength a multi-function formula containing n-dimensional random variables is established based on the stress-strength interference model. Then, an improved first-order second-moment method is adopted to solve the formula already mentioned as a basis of that to calculate the reliability of the dynamic clamping force of the chuck. The results of this study indicate that the maximum rotating speed of the CMTSC is 1000 rpm, accordingly, the reliability of the CMTSC meets the requirements of the machining. The results of the paper have merits in reliability analysis, extreme rotational speed determination, and structural optimization of the CMTSC.
Improving the Reliability of Solid Rocket Motor Demoulding Monitoring System through Software Configuration
Authors: Pang Bo , Li Hai-Bin , Shi Zhi-Guo , Wang Jing-Lei 
Published: February 2021

Abstract
Solid rocket motor demoulding is to take out the core mold solidified in the grain by pulling or pushing. At present, the manual demoulding mode with Jack or crown block auxiliary operation is often used in China, which can not effectively control the demoulding force and speed, and the change of friction sensitivity caused by the impact vibration and speed mutation is the main source of the accident. Therefore, this paper developed a remote real-time control system for the demoulding operation of small solid rocket. The operator can realize the remote real-time monitoring of the whole demoulding process in the isolated control room. Accordingly, the remote monitoring system has higher and higher requirements for equipment reliability. In view of this situation, this paper introduces several commonly used redundancy technologies and configuration environment century star, discusses the method of using soft redundancy technology to improve system reliability, and develops a set of specific implementation scheme. The practical application shows that the stability and reliability of the system have been improved obviously, and the operation effect of the system is good. The system can be widely used in data acquisition, data exchange and other occasions requiring continuous operation of the computer.
The Warship Equipment Life Cycle Design Based on the Supportability System Engineering for the People’s Armed Police Coast Guard
Authors: Biao Xing 
Published: February 2021

Abstract
According to the actual requirement and the existing situation of the Warship Equipment Support, the article makes its main research on the People’s Armed Police Coast Guard, and describes the concept and connotation of the warship equipment support design. It proposes the life cycle design based on the supportability system engineering in order to make the later costs lower, which includes the Project stage, the Argument stage, the Design stage, the Usage stage, the Maintenance and Support stage and the Scrapped stage. Finally it summarizes the project and technological approaches which can realize the support target from the project demonstration phase to the using support phase. The warship equipment life cycle design aims at solving the generated problem of the system of systems support capability, and can improve the logistical support system, innovative the support model, enhanced the logistical support capability.
Optimization for a centrifugal pump transporting brine using orthogonal design based on CFD-DEM simulation
Authors: Tang C , Kim YJ 
Published: February 2021

Abstract
To enhance the reliability of a centrifugal pump transporting brine solutions with crystallization, the effect of impeller geometrical configurations on crystal particle behaviors was investigated by an orthogonal design based on CFD-DEM coupled method. In this work, the main impeller geometrical configurations were set as the blade inlet angle α1, blade outlet angle α2, wrap angle φ, and outlet width b2. In the meanwhile, the L9(34) orthogonal design containing 4 factors with 3 levels was applied in this study. Given the crystal particle features, CFD-DEM coupling method was utilized to study inner flow in a pump with crystal particles. Current results indicated that the blade outlet angle α2 could significantly affect the collisions between particles and blades. Moreover, a low-speed region at the blade pressure side in the optimal impeller has been reduced, declining the probability of the crystal particles adhering to the impeller.
Reliability optimization analysis of blades of the mixer based on stress-strength interference model
Authors: Li Nan-Xi , Cheng Hai-Ying , Liu Jiang 
Published: February 2021

Abstract
In order to increase the service life of mixer blades, the reliability of mixer blades is optimized. In this paper, the reliability of the blade of the mixer is calculated by combining the stress-strength interference model and the discrete element method. Furthermore, the orthogonal experimental design and regression analysis are combined to obtain a significantly higher regression equation with fewer experiments. According to the established relationship between the mixer parameters and the reliability of the blades, with reliability as the goal, particle swarm optimization is used to optimize the parameters of the mixer. Finally, a twin-shaft mixer that mixes foamed asphalt mixture is used as an example to verify the feasibility of this optimization method.
Life Prediction Method of On-board Hydrogen Clock under Multiple Mechanisms
Authors: Xiong Xiao , Zhao Haitao , Xie Yonghui , Zhao Jianyu 
Published: February 2021

Abstract
As the on-board time reference of the navigation system ranging, the on-board hydrogen clock is the core part of the payload of the satellite navigation system, and its lifetime directly determines the duration of the navigation satellite mission. In order to meet the demand for life prediction of on-board hydrogen clocks, this paper expounds the composing and design of the hydrogen clock and focuses on the factors affecting the lifetime. In general, the factors include: the hydrogen supply period of the hydrogen component in the vacuum module, the period of the vacuum system to maintain a specific vacuum degree, the degradation speed of the bulb coating, the atomic preparation ability including the ionization device of the ionization bulb and the ionization circuit, the performance of the magnetic shielding and other key factors. In addition, the key performance indicators are also considered. The telemetry data and the test data of the key components on the ground are comprehensively utilized to evaluate the lifetime at which the relevant performance parameters reach the threshold. Based on the random failure, degradation, consumption and the key performance indicators of the hydrogen clock, a multi-mechanical and competitive life prediction method is proposed. The case study shows that the new method can be used to get the more dependable results of life prediction.
Integrated modeling method of Cyber physical system based on extended AADL
Authors: Renya He , Lijin Wu , Longli Tang , Xinyu Han , Zhaowei Xu , Guoqiang Gu 
Published: February 2021

Abstract
The concept and connotation of CPS are analyzed firstly in the paper, then the challenges of system modeling brought by heterogeneous feature of the CPS system are pointed out. How to describe the CPS model are studied. We propose a description method of CPS integrated modeling framework based on extended AADL (architecture analysis and design language); and realize the unified description of the computing entity, the physical entity and interactive entity through extending the standard and appendix of AADL.
Effect of phase transition on the mechanical properties of FeCoCrNiMnAlx (x = 0.5, 0.75) high-entropy alloy cladding layer
Authors: Cui Yan , Shen Junqi , Marwana Manladan Sunusi , Geng Keping , Hu Shengsun 
Published: February 2021

Abstract
The FeCoCrNiMnAlx (x = 0.5, 0.75) high-entropy alloy coatings were produced by laser cladding method, and the influence of phase transition was studied. The density and distribution of dislocation, the evolutions of phase and microstructure were investigated by using EBSD, XRD and TEM. Results presented that the higher content of Al element not only refined the grain size of the cladding layer, but also promoted the transition from FCC phase to BCC phase. All the phases in the FeCoCrNiMnAlx (x = 0.5, 0.75) cladding layers developed serious lattice distortions. The anti-plastic deformation ability of the FeCoCrNiMnAl0.75 cladding layer was effectively improved due to the accumulation of a large number of dislocations in the soft FCC phase. The yield strength and tensile strength of the FeCoCrNiMnAl0.75 cladding layers were improved significantly under the joint action of fine-grain strengthening, lattice distortion enhancement, dislocation strengthening and solid-solution strengthening.
Surface profile and topography filtering by Legendre polynomials
Authors: Haitjema Han 
Published: February 2021

Abstract
A surface filtering method based on Legendre polynomials is proposed that can be used to separate form and roughness of surface profiles and areal topographies. The filter has been designed in such a way that it well approaches the properties of a Gaussian filter, especially in the center of the measured region. Theoretical profiles and measurement examples show that there is little difference to the zero- and second order Gaussian regression filters, both in the obtained topography and in the calculated profile- and areal parameters. Compared to the Gaussian regression filters the filtering becomes gradually weaker outside the center of the profile/area, while for the Gaussian Regression filters the filtering is constant over the profile/area, but becomes weaker at the edge region within half of the L-nesting index distance. Especially for cases where the nesting index is equal to or not much smaller than the dimensions of the measured area, such as the default case according to ISO 25178-2:2012, the principal advantage of the polynomial filter is that the form removal is an integral part of the filtering, so it does not interact with the filter and does not need to be carried out separately. Also the reference plane is principally unchanged after application of this filter. Some applications are shown and a fast numerical implementation is given.
DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration
Authors: Wang Yongcui , Yang Yingxi , Chen Shilong , Wang Jiguang 
Published: February 2021

AbstractRecent pharmacogenomic studies that generate sequencing data coupled with pharmacological characteristics for patient-derived cancer cell lines led to large amounts of multi-omics data for precision cancer medicine. Among various obstacles hindering clinical translation, lacking effective methods for multimodal and multisource data integration is becoming a bottleneck.Here we proposed DeepDRK, a machine learning framework for deciphering drug response through kernel-based data integration. To transfer information among different drugs and cancer types, we trained deep neural networks on more than 20 000 pan-cancer cell line-anticancer drug pairs. These pairs were characterized by kernel-based similarity matrices integrating multisource and multi-omics data including genomics, transcriptomics, epigenomics, chemical properties of compounds and known drug-target interactions. Applied to benchmark cancer cell line datasets, our model surpassed previous approaches with higher accuracy and better robustness. Then we applied our model on newly established patient-derived cancer cell lines and achieved satisfactory performance with AUC of 0.84 and AUPRC of 0.77. Moreover, DeepDRK was used to predict clinical response of cancer patients. Notably, the prediction of DeepDRK correlated well with clinical outcome of patients and revealed multiple drug repurposing candidates. In sum, DeepDRK provided a computational method to predict drug response of cancer cells from integrating pharmacogenomic datasets, offering an alternative way to prioritize repurposing drugs in precision cancer treatment.The DeepDRK is freely available via https://github.com/wangyc82/DeepDRK.
Non-steroidal anti-inflammatory drugs and gabapentinoids for chronic lumbar pain: a Bayesian network meta-analysis of randomized controlled trials
Authors: Migliorini Filippo , Maffulli Nicola , Eschweiler Jörg , Tingart Markus , Baroncini Alice 
Published: February 2021

Abstract

Introduction
Several pharmacological therapies have been proposed for the management of chronic low back pain (LBP), but no consensus has been reached yet.

Source of data
Recent published literatures identified accessing PubMed, Google scholar, Embase and Scopus.

Areas of agreement
Exploring effective conservative alternatives to the surgical intervention is of especial interest.

Areas of controversy
The efficacy and safety of non-steroidal anti-inflammatory drugs and gabapentinoids for chronic LBP are debated. Several clinical studies showed controversial results, and the most effective and safe class of drugs has not yet been clarified.

Growing points
The effects of selective and non-selective NSAIDs and gabapentinoids in chronic LBP are probably over-estimated.

Areas timely for developing research
The effect of behavioural changes, including exercise, should be explored, alone or in combination with drugs.
Impact of in-flight use of FFP2 masks on oxygen saturation: an experimental crossover study
Authors: Sammito Stefan , Müller Geraldine P J , Erley Oliver Maria , Werner Andreas 
Published: February 2021

This study was able to show in a crossover design that neither at resting conditions nor during a simulated 80 min flight wearing the examined FFP2 face mask leads to changes in the SpO2, the heart rate or the parameters of the capillary blood gas analysis.
Bronchiolitis
Authors: Fulton Crawford , Thorburn Kentigern 
Published: February 2021

Abstract
Bronchiolitis is one of the commonest reasons for paediatric critical care admission in infants. This chapter explores the epidemiology of bronchiolitis, risk factors for severe illness, and various management strategies. In particular, this chapter explores the assessment of a deteriorating child with bronchiolitis and escalation strategies, including high-flow nasal cannula oxygen and non-invasive respiratory support progressing to invasive mechanical ventilation. This chapter includes a review of the literature related to supportive therapies such as nebulized saline, bronchodilators, and saturation targets. Indications for intubation, various intensive care strategies, and their relative effectiveness are also discussed. The role of respiratory extracorporeal membrane oxygenation in bronchiolitis is also explored.
Paediatric acute respiratory distress syndrome
Authors: Eberhardt Christiane S. , Rimensberger Peter C. 
Published: February 2021

Abstract
Acute respiratory distress syndrome (ARDS) is an important condition associated with significant morbidity and mortality in both adults and children. Chapter 6 begins by explaining the definition of paediatric ARDS (PARDS), its severity stratification, risk factors for its development, and its pathophysiology. The evidence base for lung-protective ventilation strategies is covered, with recommended goals given permissive hypoxaemia and hypercapnia. Different modes of ventilation for ARDS are examined: non-invasive ventilation, conventional mechanical ventilation, high-frequency oscillatory ventilation, and neutrally-adjusted ventilator assist, and the relative merits of pressure and volume limitation for lung protection in adults and children. Adjuvant therapies for PARDS are explored: fluid restriction; neuromuscular blocking agents; prone positioning; steroids; inhaled nitric oxide; and surfactant therapy. The chapter concludes by addressing the challenges that remain in defining and managing ARDS, and suggests how patients should be followed up following discharge.
Difficult airway in the Paediatric Intensive Care Unit
Authors: O’Donohoe Elizabeth , Breen Thomas , Reynolds Fiona 
Published: February 2021

Abstract
Children with difficult airways can come to significant harm if not appropriately assessed and managed. Chapter 10 discusses the signs of airway compromise in children and indications for intubation in the Intensive Care Unit (ICU). The role of the paediatric airway in respiratory physiology is examined. Recognizing a difficult paediatric airway is vital in the ICU—common causes of upper airway obstruction are listed and techniques for assessing paediatric airways addressed. The choice of drugs for rapid sequence induction in the Paediatric ICU is explained, and algorithms for the management of the unanticipated difficult tracheal intubation and ‘cannot intubate, cannot ventilate’ illustrated. Finally, the chapter includes the fundamental concepts of team brief, checklists, and crisis resource management in the safe management of difficult airways in children.
Extracorporeal life support
Authors: Barbaro Ryan P. , Annich Gail , Kirsch Roxanne 
Published: February 2021

Abstract
Using the narrative about a child with severe respiratory infection and septic shock, this chapter illustrates important learning points around both veno-arterial and veno-venous extracorporeal life support (ECLS) in children. Several important considerations such as patient selection, anticoagulation, management of bleeding complications, and respiratory rehabilitation on ECLS are discussed. The chapter includes a brief discussion of other forms of mechanical circulatory support (e.g. ventricular assist device) and early mobilization while on ECLS. The chapter highlights difficulties with prognostication, ethical decision-making dilemmas in patients on longer-term ECLS support, and provides a useful framework for decision-making.
Gynaecology
Authors: Goumalatsou Charlotte 
Published: February 2021

AbstractThis chapter in the Oxford Handbook of Clinical Specialties describes the gynaecology specialty, including history and examination, sexual health and dysfunction, gynaecological anatomy, genital abnormalities, and female genital mutilation. It also explores menstruation, polycystic ovarian syndrome, menorrhagia, premenstrual syndrome, menopause, and HRT (hormone replacement therapy). It discusses pregnancy, including termination, miscarriage, and ectopic pregnancy. It investigates the vulva, vaginal discharge, PID (pelvic inflammatory disease), the uterus, pelvic pain, dyspareunia, fibroids (uterine leiomyomata), and endometriosis. It explores subfertility and ovarian hyperstimulation syndrome. It describes contraception and sterilization, as well as incontinence and prolapse. It investigates vulval lumps, ulcers, carcinoma, and cervical screening. It describes cancer, including vaginal, ovarian, and endometrial, as well as benign ovarian tumours and gynaecological surgery.
Orthopaedics
Authors: Clutton Juliet 
Published: February 2021

AbstractThis chapter in the Oxford Handbook of Clinical Specialties explores orthopaedics. It explains terminology and principles of examination, and reviews different areas of the body in turn: the neck and neck pathologies are described, as well as the shoulder, elbow, wrist, and hand. Back examination is discussed and causes of back pain are described alongside simple lower back pain and specific and sometimes sinister back pain. The hip is investigated, from history and examination to painful hips in children and developmental dysplasia. Knees and feet are explored, including club foot and knee history and examination, pain in the knee, and knees that swell. Bones are discussed, including osteomyelitis and benign and malignant bone tumours, congenital disorders of bone and cartilage, and osteochondroses. Joints are investigated, from joint replacement (arthroplasty) to aspiration, injections, and tendon rupture and injury. Soft tissue and sports injuries are also explored.
Emergency medicine
Authors: Graham Blair 
Published: February 2021

AbstractThis chapter in the Oxford Handbook of Clinical Specialties explores the specialty of emergency medicine. It describes the work of a doctor in the emergency department (ED), including an overview of emergency medicine and ED teams, triage, crowding, exit block, clinical decision-making, patient expectations, and patient assessment. It investigates common procedures in depth, including advanced life support and management of pain and sedation. It discusses commonly encountered problems such as shock, the unwell child, and major trauma from brain injury to thoracic, abdominal, and pelvic trauma, as well as major burns, environmental emergencies, emergency toxicology, sepsis, loss of consciousness, stroke, acute severe headache, chest pain, acute shortness of breath, abdominal pain, atraumatic back pain, extremity problems, common limb injuries, bites and stings, foreign body ingestion, and wound care.
Pre-hospital emergency medicine
Authors: Collingwood Terry 
Published: February 2021

AbstractThis chapter in the Oxford Handbook of Clinical Specialties explores the specialty of pre-hospital emergency medicine. It reviews pre-hospital emergency medicine in general, including activation of the emergency services and major trauma networks in the UK. It gives practical advice on assessment on arrival at the scene, hazards to consider, triage, and initial patient assessment before going into specifics including how to deal with shock, the entrapped patient, pre-hospital analgesia, splintage and manipulation, and injuries to the head, spine, and chest. It explores pre-hospital care of special interest groups and emergency anaesthesia, traumatic cardiac arrest, and how to approach a major incident. It investigates the importance of public health, and how to develop lasting resilience as a member of the pre-hospital emergency team.