bluuebunny/crossref_metadata_2025_split huggingface dataset:
KCTD11 inhibits progression of lung cancer by binding to β‐catenin to regulate the activity of the Wnt and Hippo pathways
Authors: Yang Man , Han Ya‐mei , Han Qiang , Rong Xue‐zhu , Liu Xiao‐fang , Ln Xu‐Yong 
Published: August 2021

AbstractKCTD11 has been reported to be a potential tumour suppressor in several tumour types. However, the expression of KCTD11 and its role has not been reported in human non‐small cell lung cancer (NSCLC). Whether its potential molecular mechanism is related to its BTB domain is also unknown. The expression of KCTD11 in 139 NSCLC tissue samples was detected by immunohistochemistry, and its correlation with clinicopathological factors was analysed. The effect of KCTD11 on the biological behaviour of lung cancer cells was verified in vitro and in vivo. Its effect on the epithelial‐mesenchymal transition(EMT)process and the Wnt/β‐catenin and Hippo/YAP pathways were observed by Western blot, dual‐luciferase assay, RT‐qPCR, immunofluorescence and immunoprecipitation. KCTD11 is under‐expressed in lung cancer tissues and cells and was negatively correlated with the degree of differentiation, tumour‐node‐metastasis (TNM) stage and lymph node metastasis. Low KCTD11 expression was associated with poor prognosis. KCTD11 overexpression inhibited the proliferation and migration of lung cancer cells. Further studies indicated that KCTD11 inhibited the Wnt pathway, activated the Hippo pathway and inhibited EMT processes by inhibiting the nuclear translocation of β‐catenin and YAP. KCTD11 lost its stimulatory effect on the Hippo pathway after knock down of β‐catenin. These findings confirm that KCTD11 inhibits β‐catenin and YAP nuclear translocation as well as the malignant phenotype of lung cancer cells by interacting with β‐catenin. This provides an important experimental basis for the interaction between KCTD11, β‐catenin and YAP, further revealing the link between the Wnt and Hippo pathways.
Association of glycemic variability assessed by continuous glucose monitoring with subclinical diabetic polyneuropathy in type 2 diabetes patients
Authors: Pan Jiemin , Yan Xinfeng , Li Fengwen , Zhang Yinan , Jiang Lan , Wang Congrong 
Published: August 2021

AbstractAims/IntroductionDiabetic peripheral neuropathy is a common diabetes‐related microvascular complication. The relationship between peripheral nerve function and glucose variability is unclear. We investigated the association of glucose variability with subclinical diabetic polyneuropathy in a large‐scale sample of patients with type 2 diabetes.Materials and MethodsWe enrolled 509 individuals with type 2 diabetes who were screened for diabetic peripheral neuropathy and monitored using a continuous glucose monitoring system. Multiple glycemic variability parameters, including the mean amplitude of glycemic excursions, glucose standard deviation (SDgluc) and glucose coefficient of variation were calculated from 3‐day glucose profiles obtained from continuous glucose monitoring. All participants underwent nerve conduction studies, and the composite Z‐scores for nerve conduction parameters were calculated.ResultsMultivariate logistic regression analyses showed that SDgluc and the conventional risk factor hemoglobin A1c (HbA1c) were independently associated with abnormal nerve function, and the corresponding odds ratios (95% confidence interval) were 1.198 (1.027–1.397, SDgluc) and 1.182 (1.061–1.316, HbA1c), respectively. The composite Z‐score of nerve conduction velocity and response amplitude obviously decreased with greater SDgluc, and the composite Z‐score of distal latency significantly increased with increasing tertiles of SDgluc (all P trend <0.05). After adjusting for age, sex, body mass index, diabetes duration and HbA1c, SDgluc was independently associated with nerve conduction velocity (β = −0.124, P = 0.021).ConclusionsThe SDgluc is a significant independent contributor to subclinical diabetic polyneuropathy, in addition to conventional risk factors including diabetes duration and HbA1c.
Parasitic copepod (Lernanthropus kroyeri) on caged sea bass (Dicentrarchus labrax): An estimation of abundance and internal infestation pressure
Authors: Yavuzcan Yıldız Hijran , Korkmaz Ahmet Şeref 
Published: August 2021

AbstractInfestation by parasitic copepods is a substantial problem in the cage culture of European sea bass (Dicentrarchus labrax). The Copepoda parasite, Lernanthropus kroyeri (Lernanthropidae), is one of the threats to the mariculture of sea bass. In the present study, we evaluated the data of abundance for L. kroyeri pre‐adults and adult males (PAAM) and ovigerous adult females (AFo) to estimate the internal infection pressure (IIP) in the same cage environment. The sea bass infested by L. kroyeri was collected from grow‐out sea cages located in Gulluk Bay (Turkey) in September and October 2019. Mean fish weight and length of sea bass were 75.79 ± 1.66 g and 21.40 ± 0.56 cm, respectively. The fixed lag method was used to predict the abundance of L. kroyeri adult females. The overall prevalence of L. kroyeri was 60%. The mean abundance of PAAM and AFo varied from 0.8 ± 0.24 to 2.5 ± 0.67 and 2.9 ± 0.40 to 4.3 ± 0.55, respectively. The abundance of AF was strongly correlated with PAAM. The pattern of AFo and PAAM was interpreted as an indication of the continuous infestation of L. kroyeri on sea bass. Our results showed that the correlation of AFo abundance for five consecutive weeks was significant, representing the main determinative factor for the continuity of the parasitic load. In our approach, internal infestation pressure is the quantitative estimation of the potential infective copepodids, which are mainly characterized by AF abundance and the prevalence. We predicted that the internal infestation pressure could be high, even exceeding the 50.000 × 106 potential infective copepodids for one sea cage with the fish density of 20 sea bass/m3.
Estimation of entity‐level land use and its application in urban sectoral land use footprint: A bottom‐up model with emerging geospatial data
Authors: Xie Wei , Yu Huajun , Li Yang , Dai Min , Long Xinyi , Li Nan , Wang Yutao 
Published: August 2021

AbstractLand is an essential resource tomaintain the functioning of the socio‐economic system. Due to sectoral land data limitations, previous studies were primarily restricted to a coarse sectoral level or focused mainly on the global and national scales. However,fine‐scale land use data are required to provide tailored implications for municipal sustainable development. With emerging geographic data and novel methods, including point of interest data, road network data, and natural language processing, a bottom‐up model is developed to estimate the entity‐level artificial impervious land use. Then, we conducted a case study in Shanghai to investigate the spatial features, footprints, and intensities of sectoral land use. Our results indicated that 42 sectors in Shanghai had diverse spatial patterns. The transportation sector had the highest level of agglomeration among all sectors, and the manufacturing industry's adjacent land patches had higher sectoral heterogeneities than the service sector. The transportation sector had the largest direct and embodied land use footprint. The residential‐related sectors had higher land use intensities, while the high value‐added service sectors showed lower land use intensities. Our study indicates that this model offers a novel way of extracting entity‐level spatial land use information and is applicable for socio‐economic metabolism research. Future studies could incorporate remote sensing images and multiple databases to achieve higher resolution.
Barriers to the circular economy: The case of the Dutch technical and interior textiles industries
Authors: Hartley Kris , Roosendaal Jasper , Kirchherr Julian 
Published: August 2021

AbstractThe academic literature offers some insights about lagging progress on circular economy (CE) transition, including cultural, regulatory, market, and technical barriers. There is also an increasing body of knowledge about barriers to CE adoption that takes a macro‐level perspective across industries. However, such studies have largely neglected the industry scale. This study fills that gap by examining barriers to CE transition in the Dutch technical and interior textiles industries. Using data from 27 interviews with manufacturers and retailers, the study finds that high costs for production and marketing, along with lack of consumer interest, are among the most substantial barriers. To provide a system‐wide perspective, the study conceptualizes relationships among barriers as a chain reaction: limited knowledge of CE design options raises the difficulty and cost of delivering high‐quality circular products at the firm level, while limited availability of circular supply streams combined with the orientation of existing production systems toward linear supply chains constrain CE transition at the industry level. These findings highlight the need for intervention at levels beyond the scale of individual firms, a key implication for public policy.
Spontaneous, transient adenosine release is not enhanced in the CA1 region of hippocampus during severe ischemia models
Authors: Ganesana Mallikarjunarao , Venton B. Jill 
Published: August 2021

AbstractIschemic stroke causes damage in the brain, and a slow buildup of adenosine is neuroprotective during ischemic injury. Spontaneous, transient adenosine signaling, lasting only 3 s per event, has been discovered that increases in frequency in the caudate‐putamen during early stages of mild ischemia‐reperfusion injury. However, spontaneous adenosine changes have not been studied in the hippocampus during ischemia, an area highly susceptible to stroke. Here, we investigated changes of spontaneous, transient adenosine in the CA1 region of rat hippocampus during three different models of the varied intensity of ischemia. During the early stages of the milder bilateral common carotid artery occlusion (BCCAO) model, there were fewer spontaneous, transient adenosine, but no change in the concentration of individual events. In contrast, during the moderate 2 vertebral artery occlusion (2VAO) and severe 4 vessel occlusion (4VO) models, both the frequency of spontaneous, transient adenosine and the average event adenosine concentration decreased. Blood flow measurements validate that the ischemia models decreased blood flow, and corresponding pathological changes were observed by transmission electron microscopy (TEM). 4VO occlusion showed the most severe damage in histology and BCCAO showed the least. Overall, our data suggest that there is no enhanced spontaneous adenosine release in the hippocampus during moderate and severe ischemia, which could be due to depletion of the rapidly releasable adenosine pool. Thus, during ischemic stroke, there are fewer spontaneous adenosine events that could inhibit neurotransmission, which might lead to more damage and less neuroprotection in the hippocampus CA1 region.
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Consumer marketplaces and self‐sufficiency: Meeting consumption needs in community
Authors: Saunders Stephen G. , Sridharan Srinivas , Barrington Dani J. , Souter Regina , Shields Katherine F. , Meo Semisi , Bartram Jamie K. 
Published: August 2021

AbstractGuided by a “logic of the situation” approach our research investigated a problematic situation in community to identify and critically reflect on how consumer marketplaces and self‐sufficiency meet consumption needs. In doing so, we reflect on how a situational understanding allowed the researchers to form a more complete view of how consumption needs were met in community through enabler‐led marketplaces, community‐led marketplaces and self‐sufficiency. We also re‐conceptualized our thinking as a more broadly conceived hybrid consumer marketplace to reflect our more complete understanding. We discuss the theoretical and practical implications of our more broadly conceived hybrid consumer marketplace and provide a foundation for further research into consumer marketplaces and meeting consumption needs.
Quality of professional life of primary healthcare nurses: A systematic review
Authors: Laserna Jiménez Cristina , Casado Montañés Isabel , Carol Marta , Guix‐ Comellas Eva Maria , Fabrellas Núria 
Published: August 2021

AbstractAimsTo identify and critically appraise the available evidence on the overall quality of professional life of primary care nurses worldwide and its main influencing factors.BackgroundQuality of professional life of healthcare workers is a keystone that influences the quality of healthcare services provided by healthcare organisations. Nurses have a key role as healthcare services providers given the growing shortage of doctors in primary care.DesignA systematic review design in accordance with the PRISMA statement.MethodsThe search was conducted through MEDLINE (PubMed), CINAHL, SCOPUS, Scientific Electronic Library Online (SciELO) and Web of Science databases. The grey literature was reviewed at OpenGrey. The search was limited to human studies published from April 2010–April 2020. No limit of original language publication was applied. Three independent reviewers analysed the methodological quality of the studies.ResultsTen studies were included from five countries. Five studies reported nurses were satisfied with their quality of professional life and the influencing factors identified were Workload, Job autonomy, Demographic variables, Management support, Recognition, Intrinsic motivation, Interpersonal relations, Compassion fatigue, Burnout, Turnover intention, and work was reported as a component of Quality of life.ConclusionPrimary healthcare nurses reported a high level of quality of professional life, but the scarce studies found do not provide solid consistency to assess the overall quality of professional life. Perception of high workload was the most frequently identified factor to negatively influence the quality of professional life of nurses.Relevance to clinical practiceQuality of professional life of primary care nurses is a key issue because of nurses’ important relation with patient's care and satisfaction. Healthcare organisations should strive to address primary care nurses’ quality of professional life to enhance their well‐being and consequently patients’ safety and high‐quality healthcare services.
High‐fidelity simulation and nurse clinical competence—An integrative review
Authors: O’Rourke Laura A. , Morrison Megan , Grimsley Amy , Cotter Valerie T. 
Published: August 2021

AbstractAimThe aim of this review was to synthesise current knowledge of high‐fidelity simulation practices and its impact on nurse clinical competence in the acute care setting.BackgroundThere is no consensus or standardisation surrounding best practices for the delivery of high‐fidelity simulation in the acute care setting. This is an understudied area.DesignAn integrative review using Johns Hopkins Nursing Evidence‐Based Practice Model.MethodsMedical subject heading terms ‘Clinical Competence’, AND ‘High Fidelity Simulation Training’, AND ‘Clinical Deterioration’ were systematically searched in PubMed, CINAHL and Embase databases for peer‐reviewed literature published through September 2020. The current study was evaluated using PRISMA checklist.ResultsSeven studies met the inclusion criteria. Three main concepts were identified: modes of delivery, approach to learner participation and outcome measurement.ConclusionsThis review substantiated the use of high‐fidelity simulation to improve acute care nurses’ early identification and management of clinical deterioration. Global variations in course design and implementation highlight the need for future approaches to be standardised at the regional level (i.e., country‐centric approach) where differing scopes of practice and sociocultural complexities are best contextualised.Relevance to clinical practiceThese findings add to the growing body of evidence of simulation science. Important considerations in course planning and design for nursing clinical educators were uncovered. This is especially relevant given the current COVID‐19 pandemic and urgent need to train redeployed nurses safely and effectively from other units and specialties to acute care.
Social integration and well‐being of North Korean migrants in South Korea
Authors: Yoon In‐Jin 
Published: August 2021

AbstractI examined the social integration and well‐being of North Korean migrants in South Korea, guided by a modified model of migrant integration that includes indicators of both systemic integration and value integration of North Korean migrants. The level of systemic integration was measured using indicators of employment, education, housing, and health. The level of value integration was measured using indicators of a sense of belonging, a sense of trust, and multicultural acceptance. The main data for this study were collected by a telephone survey of 400 North Korean migrants aged 15 and over conducted from November 24, 2016 to December 7, 2016. Data analysis revealed a low level of systemic integration and poor health condition of North Korean migrants. The level of value integration was intermediate. North Korean migrants strongly identified as South Korean citizens and strongly believed that they could reach the same status as South Koreans. However, their North Korean culture and identity were not recognized or accepted in South Korean society and they felt strong pressure to assimilate to South Korean culture and identity.
Sleep in adults from the UK during the first few months of the coronavirus outbreak
Authors: Madrid‐Valero Juan J. , Bowling Natalie , Vafeiadou Aikaterini , Buysse Daniel J. , Banissy Michael J. , Gregory Alice M. 
Published: August 2021

SummaryThe coronavirus disease 2019 (COVID‐19) outbreak emerged at the end of 2019 and quickly spread around the world. Measures to counter COVID‐19, including social distancing and lockdowns, created an unusual situation that had the potential to impact a variety of behaviours, including sleep, which is crucial for health and well‐being. Data were obtained through an online survey. The total sample comprised 19,482 participants from the UK. Participants were asked several questions regarding sleep quality and quantity. Each participant completed the questionnaires once during a data collection period spanning January 20 to March 31, 2020. Data provided by different participants during different weeks (spanning time‐periods just before COVID‐19 was identified in the UK and during the early weeks following its arrival) were compared using analysis of variance tests and regressions. Regression analyses controlling for age, sex and ethnicity revealed significant associations of small magnitude between date of survey completion and sleep quality, sleep latency, number of awakenings and composite score of poor sleep quality. These analyses also indicated small increases in eveningness tendency as the study progressed. There was no change in sleep duration or time spent awake at night. The COVID‐19 outbreak did not appear to impact negatively sleep in a substantial manner during the early stages in the UK. The small increases in sleep quality variables (except for time spent awake at night and sleep duration) and eveningness are nonetheless of interest. Further research is needed to understand how best to provide support to those most in need of a good night’s sleep during this unprecedented time.
Elucidation of impact event recorded in the lherzolitic shergottite NWA 7397
Authors: Yoshida Masashi , Miyahara Masaaki , Suga Hiroki , Yamaguchi Akira , Tomioka Naotaka , Sakai Takeshi , Ohfuji Hiroaki , Maeda Fumiya , Ohira Itaru , Ohtani Eiji , Kamada Seiji , Ohigashi Takuji , Inagaki Yuichi , Kodama Yu , Hirao Naohisa 
Published: August 2021

AbstractThe (plagioclase) lherzolitic shergottite Northwest Africa (NWA) 7397 consists of poikilitic and non‐poikilitic lithologies. Coarse‐grained low‐Ca pyroxene oikocrysts enclose olivine and chromite grains in the poikilitic lithology. The major constituents of the non‐poikilitic lithology are olivine, Ca‐pyroxene, and plagioclase. Minor amounts of chromite, ilmenite, alkali feldspar, Ca‐phosphate, and iron‐sulfide are included in the non‐poikilitic lithology. Most plagioclase grains in the non‐poikilitic lithology have become maskelynite. A melt pocket occurs in the non‐poikilitic lithology. Plagioclase in contact with the melt pocket has dissociated into zagamiite + stishovite. Apatite and merrillite entrained in the melt pocket have transformed into tuite. Olivine in contact with the melt pocket has dissociated into bridgmanite (almost vitrified) + ferroan‐periclase. Alteration products, iron oxides and hydroxides, also occur in the dissociated olivine although it is not clear when the aqueous alteration occurred. The dissociation reactions of olivine and plagioclase into the high‐pressure polymorphs (bridgmanite, ferroan‐periclase, zagamiite, and stishovite) are found from lherzolitic shergottites for the first time. The estimated peak shock‐pressure and ‐temperature conditions recorded in melt pockets of NWA 7397 are ˜23 GPa and 2,000 °C at least, respectively, based on the high‐pressure mineral assemblages.
Functional validation of pathogenicity genes in rice sheath blight pathogen Rhizoctonia solani by a novel host‐induced gene silencing system
Authors: Zhao Mei , Wang Chenjiaozi , Wan Jun , Li Zanfeng , Liu Dilin , Yamamoto Naoki , Zhou Erxun , Shu Canwei 
Published: August 2021

AbstractRice sheath blight, caused by the soilborne fungus Rhizoctonia solani, causes severe yield losses worldwide. Elucidation of the pathogenic mechanism of R. solani is highly desired. However, the lack of a stable genetic transformation system has made it challenging to examine genes' functions in this fungus. Here, we present functional validation of pathogenicity genes in the rice sheath blight pathogen R. solani by a newly established tobacco rattle virus (TRV)–host‐induced gene silencing (HIGS) system using the virulent R. solani AG‐1 IA strain GD‐118. RNA interference constructs of 33 candidate pathogenicity genes were infiltrated into Nicotiana benthamiana leaves with the TRV‐HIGS system. Of these constructs, 29 resulted in a significant reduction in necrosis caused by GD‐118 infection. For further validation of one of the positive genes, trehalose‐6‐phosphate phosphatase (Rstps2), stable rice transformants harbouring the double‐stranded RNA (dsRNA) construct for Rstps2 were created. The transformants exhibited reduced gene expression of Rstps2, virulence, and trehalose accumulation in GD‐118. We showed that the dsRNA for Rstps2 was taken up by GD‐118 mycelia and sclerotial differentiation of GD‐118 was inhibited. These findings offer gene identification opportunities for the rice sheath blight pathogen and a theoretical basis for controlling this disease by spray‐induced gene silencing.