bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic Fragility Analysis of Base Isolated Structure Subjected to Near-fault Ground Motions
Authors: Liu Chengqing , Fang Dengjia , Yan Zhengxi 
Published: March 2021

In order to better evaluate the performance of the base isolated structure under the near-fault earthquakes, this paper takes into consideration an existing engineering case study in China as the prototype, and uses OpenSEES platform to establish the nonlinear finite element model of the base isolated structure. The nonlinear response of the isolated structure under the near-fault earthquake is analyzed. The incremental dynamic analysis (IDA) method is used to calculate the damage probability of the structure under the near-fault earthquake, and the fragility curve of the base isolated structure is established. The fragility equation is obtained by nonlinear regression, and the error of fragility equation is analyzed. The results show that the maximum value of the inter-story drift of the upper structure under the action of near-fault earthquake is significantly greater than that under the action of far-fault earthquake. With the increase of seismic intensity, the damage probability of base isolated structure increases nonlinearly, and the maximum response value of horizontal displacement of bearing and inter-story drift of superstructure increases generally. In addition, the exceeding probability of the fragility curve based on PSDA is greater than that based on EDP criterion. When the sample points of the two methods are the same, the exceeding probability points calculated based on PSDA can be regarded as accurate values. The fragility curve based on PSDA may overestimate the exceeding probability to some extent, and the overestimation may be enlarged with the increase of failure stage.
Optimal Plastic Analysis and Design of Pile Foundations Under Reliable Conditions
Authors: Movahedi Rad Majid , Khaleel Ibrahim Sarah 
Published: March 2021

In this research, in order to evaluate the plastic limit load and also plastic design parameters of the long pile foundations subjected to horizontal loads, shakedown method is applied. In carrying out shakedown analysis and design methods, large plastic deformations and residual displacements could develop in the pile foundation which might lead to the failure of the structure. For this reason, complementary strain energy of residual forces proposed as a limit condition to control the plastic deformation of the pile structure. Furthermore, considering the uncertainties (strength, manufacturing, geometry) the limit conditions on the complementary strain energy of residual forces are assumed randomly and the reliability condition was formed by the use of the strict reliability index. The influence of the limit conditions on the plastic limit load and design parameters of the long pile in cohesionless soil subjected to lateral load were investigated and limit curves for shakedown load factors are presented. The numerical results show that the probabilistic given limit conditions on the complementary strain energy of residual forces have significant influence on the load bearing limit and the design parameters of pile foundations. The formulations of the reliability based problems lead to mathematical programming which were carried out by the use of non-linear algorithm.
INTERAKSI SOSIAL ONLINE DAN KECEMASAN SOSIAL SEBAGAI PREDIKTOR KECANDUAN INTERNET PADA REMAJA
Authors: Hidayat Putra 
Published: March 2021

This study aims to examine the effect of online social interaction and social anxiety on internet addiction in adolescents. Employing an ex-post facto design, this research was conducted in the regency of Purbalingga involving 366 teenagers as sample which was determined using a multistage random sampling techniques. Data were collected through questionnaires consisting of internet addiction questionnaires, online social interaction questionnaires, and social anxiety questionnaires. These instruments were validation through content validity and reliability based on Cronbach’s Alpha coefficient. The data where then analysed by means of a multiple regression analysis.The results showed that there was a significant effect of online social interaction and social anxiety on internet addiction in adolescents (p=0,000). Therefore, it can be concluded that there is a effect between online social interaction and social anxiety towards the adolescents internet addiction. Online social interaction and social anxiety can be strong predictors of internet addiction among adolescents.
Association of Other Autoimmune Diseases With Thyroid Eye Disease
Authors: Kelada Mary , Avari Parizad , Farag Soma , Akishar Rashmi , Jain Rajni , Aziz Ahmad , Feeney Claire , Bravis Vassiliki , Meeran Karim , Lee Vickie 
Published: March 2021

BackgroundThyroid eye disease (TED) is a potentially disfiguring and sight-threatening autoimmune (AI) orbitopathy, affecting up to 400,000 people in the UK. There are no accurate early predictors of TED severity. Although polyautoimmunity has been shown to affect AI disease severity, its influence on TED severity has never been investigated. The prevalence of polyautoimmunity among TED patients is also unclear, with discordant results reported in the literature. This study evaluates the prevalence of non-thyroid/“other” AI (OAI) conditions in an ethnically diverse TED cohort and assesses how polyautoimmunity affects TED severity and activity.MethodsA retrospective study of patients presenting to multidisciplinary TED clinics across three North-West London hospitals between 2011 and 2019. Data collected included: 1) demographics; 2) OAI conditions and management; 3) endocrine management of thyroid dysfunction; 4) details of TED and clinical activity score at presentation.ResultsTwo hundred and sixty-seven patients with a median age of 46 (35–54) years were included, 79.4% were female and 55% were Black, Asian and minority ethnic (BAME). Thirty-seven patients (13.9%) had OAI conditions, with rheumatoid arthritis (3.7%), vitiligo (3.0%) and psoriasis (3.0%) among the most prevalent. Of patients with OAI conditions, 43.2% (16/37) required immunosuppression prior to TED onset. Non-immunosuppressed patients with OAI conditions had a significantly higher clinical activity score at presentation than TED-only and previously immunosuppressed patients (p=0.02). No significant differences were observed in thyroid receptor antibody titers between these groups.ConclusionsThis study finds a 13.9% prevalence of OAI conditions among TED patients. Patients with OAI conditions overall have a tendency for more severe and significantly more clinically active TED than those without OAI conditions. Larger, prospective studies are warranted to further evaluate polyautoimmunity as an early predictor of TED severity.
Comprehensive In Silico Analysis of a Novel Serum Exosome-Derived Competitive Endogenous RNA Network for Constructing a Prognostic Model for Glioblastoma
Authors: Wang Zihao , Ji Xin , Gao Lu , Guo Xiaopeng , Lian Wei , Deng Kan , Xing Bing 
Published: March 2021

PurposeGlioblastoma (GBM) is one of the most aggressive brain tumors with high mortality, and tumor-derived exosomes provide new insight into the mechanisms of GBM tumorigenesis, metastasis and therapeutic resistance. We aimed to establish an exosome-derived competitive endogenous RNA (ceRNA) network for constructing a prognostic model for GBM.MethodsWe obtained the expression profiles of long noncoding RNAs (lncRNAs), miRNAs, and mRNAs from the GEO and TCGA databases and identified differentially expressed RNAs in GBM to construct a ceRNA network. By performing lasso and multivariate Cox regression analyses, we identified optimal prognosis-related differentially expressed lncRNAs (DElncRNAs) and generated a risk score model termed the exosomal lncRNA (exo-lncRNA) signature. The exo-lncRNA signature was subsequently validated in the CGGA GBM cohort. Finally, a novel prognostic nomogram was constructed based on the exo-lncRNA signature and clinicopathological parameters and validated in the CGGA external cohort. Based on the ceRNA hypothesis, oncocers were identified based on highly positive correlations between lncRNAs and mRNAs mediated by the same miRNAs. Furthermore, regression analyses were performed to assess correlations between the expression abundances of lncRNAs in tumors and exosomes.ResultsA total of 45 DElncRNAs, six DEmiRNAs, and 38 DEmRNAs were identified, and an exosome-derived ceRNA network was built. Three optimal prognostic-related DElncRNAs, HOTAIR (HR=0.341, P&lt;0.001), SOX21-AS1 (HR=0.30, P&lt;0.001), and STEAP3-AS1 (HR=2.47, P&lt;0.001), were included to construct the exo-lncRNA signature, which was further proven to be an independent prognostic factor. The novel prognostic nomogram was constructed based on the exo-lncRNA signature, patient age, pharmacotherapy, radiotherapy, IDH mutation status, and MGMT promoter status, with a concordance index of 0.878. ROC and calibration plots both suggested that the nomogram had beneficial discrimination and predictive abilities. A total of 11 pairs of prognostic oncocers were identified. Regression analysis suggested excellent consistency of the expression abundance of the three exosomal lncRNAs between exosomes and tumor tissues.ConclusionsExosomal lncRNAs may serve as promising prognostic predictors and therapeutic targets. The prognostic nomogram based on the exo-lncRNA signature might provide an intuitive method for individualized survival prediction and facilitate better treatment strategies.
Clinical Characteristics and Prognosis of Patients With Pulmonary Mucoepidermoid Carcinoma: A SEER-Based Analysis
Authors: Qiu Lingxiao , Song Pan , Chen Pingmei , Wang Huaqi , Li Fangfang , Shu Mengxuan , Gong Gen-cheng , Song Xiangjin , Huang Chun , Jia Hongxia , Li Nana , Zhang Guojun 
Published: March 2021

BackgroundPrimary pulmonary mucoepidermoid carcinoma (PMEC) is an extremely rare malignancy. Its clinical characteristics and prognosis are not fully understood. This study evaluated clinical characteristics and prognostic factors of PMEC and established a nomogram to predict its 1-, 3-, 5- and 10-year cancer-specific survival (CSS) rates.MethodsIn the Surveillance, Epidemiology, and End Results database from January 1, 1975 to December 31, 2016, patients pathologically diagnosed with PMEC were identified. Kaplan–Meier analysis and Cox regression were performed to evaluate the CSS stratified by different covariates. A predictive nomogram model was built and validated by the concordance index (C-index) and calibration curves.ResultsA total of 585 PMEC patients were identified. A total of 408 (70%) of patients were placed into the training cohort, and 177 (30%) patients were placed into the validation cohort. The 5- and 10-year CSS rates of stage I–II PMEC patients were 91.4 and 88.9, respectively. The 1-, 3- and 5-year CSS rates of stage III–IV PMEC were 56.5, 39.45, and 32.1%, respectively. Survival curves showed that older age, large tumor size, poor differentiation, and high TNM stage were associated with a significantly worse prognosis. CSS outcomes were significantly better in patients who received surgical treatments (surgical alone, surgery plus radiation and/or chemotherapy). Patients who received radiation and/or chemotherapy had the worst prognosis. Multivariate Cox results revealed that covariates, including age, tumor laterality, tumor sizes, pathological differentiation, lymph node metastasis, distant metastasis, TNM stage and therapy, were independent prognostic factors for PMEC. These factors were used to construct a nomogram. The C-index of the nomogram was 0.921. The calibration curve presented favorable consistency between the predicted CSS and actual observations. This nomogram was validated by the validation cohort. The C-index of the validation cohort was 0.968.ConclusionAge, bilateral tumors, tumor size, pathological differentiation grade, lymph node metastasis, distant metastasis, TNM stage and therapy were independent prognostic factors of PMEC patients. The first nomogram for predicting the CSS of PMEC was built and validated, showing its potential value in practice.
Whole-Brain Radiation Therapy With Simultaneous Integrated Boost Versus Whole-Brain Radiation Therapy Plus Stereotactic Radiosurgery for the Treatment of Brain Metastasis From Lung Cancer
Authors: Lin Binwei , Huang Dan , Du Huan , Fan Jinjia , Zhang Yu , Feng Gang , Gao Feng , Du Xiao Bo 
Published: March 2021

Radiotherapy is one of the most important treatments for brain metastasis (BM). This study aimed to assess whether whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) provided any therapeutic benefit compared to WBRT followed by stereotactic radiosurgery (SRS). Seventy-two consecutive cases of lung cancer with BM treated from January 2014 to June 2020 were analyzed retrospectively. Thirty-seven patients were treated with WBRT (30 Gy in 10 fractions) and SIB (45 Gy in 10 fractions), and 35 patients were treated with WBRT (30 Gy in ten fractions) followed by SRS (16–24 Gy according to the maximum tumor diameter). The primary endpoint was intracranial progression-free survival (PFS). The secondary endpoints were intracranial objective response (partial and complete responses), pattern of intracranial progression, overall survival (OS), and toxicity. The WBRT + SIB group had a significantly longer median intracranial PFS (9.1 vs. 5.9 months, P = 0.001) than the WBRT + SRS group. The intracranial objective response rate was 67.6% and 62.9% in the WBRT + SIB and in WBRT + SRS groups, respectively (P = 0.675). The incidence of progression outside the P-GTV in the WBRT + SIB group was significantly lower than that in the WBRT + SRS group (39.4% vs. 75.0%, P = 0.004). The median OS was 24.3 and 20.3 months in the WBRT + SIB and WBRT + SRS groups, respectively (P = 0.205). There was no significant difference in the incidence of grade 3 or worse adverse reactions between the two groups. Compared to treatment with WBRT + SRS, that with WBRT + SIB for BM appeared to contribute to local control.
Progression Patterns, Treatment, and Prognosis Beyond Resistance of Responders to Immunotherapy in Advanced Non-Small Cell Lung Cancer
Authors: Xu Yanjun , Li Hui , Fan Yun 
Published: March 2021

IntroductionImmune checkpoint inhibitors (ICIs) have changed the management of non-small cell lung cancer (NSCLC). However, resistance is inevitable. The disease progression patterns, sequential treatment, and prognosis beyond ICI resistance are not completely understood.MethodsWe retrospectively analyzed stage IV NSCLC patients who underwent ICI treatment at Zhejiang Cancer Hospital between January 2016 and January 2020 and who suffered disease progression after at least stable disease on immunotherapy for more than 3 months (at least two cycles). Oligoprogression and systematic progression were defined as previous reports. The main outcome measures were progression-free survival (PFS), second PFS (PFS2), and overall survival (OS). Survival curves were plotted using the Kaplan-Meier method. The Cox proportional hazards model was used for multivariate analysis.ResultsTotally 1,014 NSCLC patients were administered immunotherapy. Of them, 208 NSCLC patients were included in this retrospective study. The estimated PFS, PFS2 and OS were 6.3 months (95% CI 5.6–7.0 months), 10.7 months (95% CI 10.1–12.7 months), and 21.4 months (95% CI 20.6–26.4 months), respectively. After resistance, 55.3% (N = 115) patients developed oligoprogression, and 44.7% (N = 93) systemic progression. For patients with systemic progression, chemotherapy (N = 35, 37.6%), best supportive care (N = 30, 32.3%), and antiangiogenic therapy alone (N = 11, 11.8%) were the major strategies. A combination of local radiotherapy (N = 38, 33.0%) with continued ICIs was the most common treatment used in oligoprogression group, followed by continued immunotherapy with antiangiogenic therapy (N = 19, 16.5%) and local radiotherapy only (N = 17, 14.9%). For patients with oligoprogression, continued immunotherapy plus local radiotherapy can lead to a significantly longer PFS2 (12.9 vs. 10.0 months; p = 0.006) and OS (26.3 vs. 18.5 months, p = 0.001). The PFS2 and OS of patients with oligoprogression were superior to those of patients with systemic progression (PFS2: 13.1 vs. 10.0 months, p = 0.001; OS: 25.8 vs. 19.1 months, p = 0.003).ConclusionsThe major progression pattern after acquired resistance from immunotherapy is oligoprogression. Local radiotherapy with continued immunotherapy beyond oligoprogression in responders was feasible and led to prolonged PFS2 and OS in advanced NSCLC patients.
Effects of Combining Meditation Techniques on Short-Term Memory, Attention, and Affect in Healthy College Students
Authors: Pragya Samani Unnata , Mehta Neelam D. , Abomoelak Bassam , Uddin Parvin , Veeramachaneni Pushya , Mehta Naina , Moore Stephanie , Jean-Francois Melissa , Garcia Stephanie , Pragya Samani Chaitanya , Mehta Devendra I. 
Published: March 2021

Meditation refers to a family of self-regulation practices that focuses on training attention and awareness to foster psycho-emotional well-being and to develop specific capacities such as calmness, clarity, and concentration. We report a prospective convenience-controlled study in which we analyzed the effect of two components of Preksha Dhyāna – buzzing bee sound meditation (Mahapran dhvani) and color meditation (leśyā dhyāna) on healthy college students. Mahapran and leśya dhyāna are two Preksha Dhyāna practices that are based on sound and green color, respectively. The study population represents a suitable target as college students experience different stress factors during the school year. This study measures the individual and combined effects of two techniques (one focusing on sound and one focusing on color), on short-term memory, attention, and affect, in novice meditators. We used a battery of cognitive, performance, and compared results with baseline and control values. We found improved cognition, especially attention, short-term memory, and affect in terms of positivity and reduced negativity. Overall, the two techniques produced variable benefits and subjects showed improved scores over baseline for short-term memory, cognitive function, and overall wellbeing. Further studies are required to understand underlying mechanisms for the observed differences between the two techniques and to elucidate mechanisms underlying the more pronounced and global benefits observed with the combined techniques. These results underscore a need to examine individual components of meditation practices in order to individualize treatment approaches for attention disorders in young adults.Clinical Trail Registration:ClinicalTrials.gov Identifier: NCT03779269.
Differential Impact of Education on Gray Matter Volume According to Sex in Cognitively Normal Older Adults: Whole Brain Surface-Based Morphometry
Authors: Kang Dong Woo , Wang Sheng-Min , Na Hae-Ran , Kim Nak-Young , Lim Hyun Kook , Lee Chang Uk 
Published: March 2021

Background:The effect of educational status on brain structural measurements depends on demographic and clinical factors in cognitively healthy older adults.Objectives:The current study aimed to evaluate the impact of interaction between years of education and sex on gray matter volume and to investigate whether cortical volume has a differential impact on cognitive function according to sex.Methods:One hundred twenty-one subjects between 60 and 85 years old were included in this study. Gray matter volume was evaluated by whole brain surface-based morphometry. Multiple regression analysis was used to analyze the effects of sex-cortical volume interactions on cognitive functions.Results:There was a significant interaction between years of education and sex on the cortical volume of the left inferior temporal gyrus after adjusting for age, APOE ε4 allele prevalence, and total intracranial volume. In addition, we found a significant impact of the interaction between adjusted left inferior temporal volume and sex on CERAD-K total scores.Conclusion:These findings have significant implications for the understanding of how sex could affect the role of cognitive reserve for cortical atrophy in cognitively intact older adults.
Unrevealed flower types of Silambu
Authors: E Indhurani 
Published: March 2021

When we look at Flower, it is natural to remember first. Kapilar is the poet of the nature. The poet himself was the first to be a poet in the style of the poet, and the study of the 99 types of flowers of Kurinjipattu is made. The three katai of The Silapathikaram contain 30 ears. Do the akkadai contain 99 types of flowers of Kurinjipatti, are there flowers that are not present, and are there any new flowers in silambu, This paper is designed to be a subject of the purpose of the study. Since it is a study of flowers, I have put the title unrevealed Varieties of Flowers in Silambu. This article is based on the study of the unknown flowers that are found in Kurinji.
Como o atleticano se tornou River
Authors: Guimarães Gustavo Cerqueira 
Published: March 2021

“Como o atleticano se tornou River: um clássico mineiro da Argentina” foi publicado em 2015, no Ludopédio, configurando-se como o primeiro experimento do autor em diálogo com a mídia e certo discurso jornalístico, no qual aborda o Atlético Mineiro e o futebol sul-americano. Aqui, reescrito, temos o despertar do interesse de Miro pelo futebol argentino após conversa com Seu Revir, o dono da banca de jornais e revistas. O professor decide, então, ir a Buenos Aires, em busca de lugares e memórias futebolísticas que marcam a presença platina na trajetória do futebol tupiniquim. Num domingo que era para ser de futebol argentino, tornou-se um Atlético e Cruzeiro entre vinhos, debates, cigarros e paradoxos... rivalidade e amizade, Miro passa por descobertas que vão além de uma paixão clubística.
Characterization of a tactile sensor using a small, embedded strain gauge
Authors: Hashimoto Yuki , Usui Tatsuya , Ishizuka Hiroki , Ikeda Sei , Oshiro Osamu 
Published: March 2021

Abstract
In recent years, tactile sensors comprising flexible materials have been studied for soft robotics. Several conventional tactile sensors are based on a microchannel filled with liquid metal, for flexibility. In this study, we proposed a soft tactile sensor that is vertically embedded with a liquid metal strain gauge in an elastomer using a narrow wire mold. Despite the narrow and small design, the strain gauge can detect an applied force. In addition, the design has the potential to be arrayed in a dense setting. In this study, we evaluated our proposed tactile sensor with a single strain gauge and confirmed its sensing capability.
SISTEM REKOMENDASI PEMILIHAN FOTOGRAFER DENGAN METODE HAVERSINE DAN TF-IDF DI MALANG RAYA
Authors: Irvandani Aditya , Auliasari Karina , Primaswara Prasetya Renaldi 
Published: March 2021

Foto merupakan suatu media pada era seperti sekarang ini untuk mengabadikan setiap momen. Acara ulang tahun, acara pernikahan maupun acara wisuda sekalipun selalu tidak luput dari kegiatan berfoto. Namun untuk mendapatkan hasil yang bagus, kita terkadang harus membayar para fotografer yang terkenal dan setidaknya selalu sudah memiliki instansi yang memperkerjakannya. Disinilah fotografer freelance atau fotografer yang tidak memiliki keterkaitan dengan instansi bisa memberikan solusi yang prakis. Sejatinya para masyarakat awam tidak selalu memiliki relasi yang bisa menjadi fotografer untuk mendokumentasikan mereka, seperti halnya juga fotografer freelance yang tidak memiliki lahan untuk memasarkan jasa mereka.
Penelitian ini bertujuan untuk mengatasi masalah dari sisi pencari jasa (client) dan fotografer dengan membuat system rekomendasi pencarian fotografer freelance yang memiliki fitur menampilkan daftar fotografer berdasarkan tempat terdekat dan spesifikasi foto yang dimilikinya seperti foto pernikahan, wisuda, produk, ulang tahun. Metode Haversine ini digunakan untuk mencari jarak dari titik pencari jasa dan tempat tinggal fotografer. Serta penggunaan metode TF-IDF (Term Frequency - Inverse Document Frequency) sebagai pencari spesifikasi dari fotografer sesuai dengan keyword yang ada di profile pencari jasa.