bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of system management to achieve global goals of sustainable development in Ukraine
Authors: Velychko Tatiana 
Published: April 2021

The subject of research is the theoretical and methodological aspects of involving system management to achieve the goals of sustainable development and practical areas of its implementation in Ukraine. The purpose of the article is the further development of areas and components of system management to achieve global goals of sustainable development in Ukraine, taking into account the principles of social responsibility and processes and opportunities for digitalization of the population. The methodological basis of the article were the theoretical and methodological provisions of economics of nature management, regional economy, demography, ecology; international and national normative-legislative acts, norms, initiatives on sustainable development. As a fundamental methodological approach, the article uses system-structural analysis and synthesis, as well as historical, monographic, statistical-economic, problem-target methods. The results of the article. The article highlights the concepts and ideas of sustainable development, identifies the features of system management for their achievement and priority areas for development for Ukraine, taking into account the country's ratings in the world community and their dynamics. Features of system management for the purposes of sustainable development are defined; identified its priority areas in Ukraine, taking into account its ratings in the global dimension. Field of application of results. In higher education institutions in the teaching of environmental economics, regional economics and sustainable development, in schools, environmental governmental and non-governmental organizations. Conclusions. It is determined that the most significant feature of the theory and practice of rural green tourism enterprises in European countries is the expansion of their functions from purely business to more socially necessary and significant - as tools for preservation and reproduction of rural areas, including depressed. This provides greater support at the level of local communities, government, which is appropriate for all uses. It is also advisable to use proven mechanisms and forms of tourism in the countryside.
Increasing the agricultural enterprises’ competitiveness based on its components and indicators accounting, evaluation and modelling
Authors: Koval Svetlana , Shakhman Karina 
Published: April 2021

The subject of the research is the theoretical, methodological principles, and practical proposals for increasing the agricultural enterprises’ competitiveness based on improving its components accounting, evaluation, and modeling. The purpose of the article is to substantiate the increase of agricultural enterprises’ competitiveness and managing it through improving accounting, evaluation, and modeling of its quantitative indices and indicators. The methodological basis of the article is the fundamentals of economic theory, business economics, and accounting; works of leading scientists on competitiveness issues; legal regulations on various aspects of agricultural enterprises and markets development. The historical and monographic methods and methods of system-structural analysis and synthesis, rating evaluation and ranking, accounting, model of competitive space are used. The results of the article. The essence of agricultural enterprises’ competitiveness is generalized, the problems of its formation are revealed and directions of improving its management are offered based on building the model of competitive space taking into account indicators of financial and economic sustainability of agribusiness, market share, and products competitiveness, and involvement of the marketing plan as well. Field of application of results. The results obtained should be used in the management of agribusiness enterprises; in the educational process of the faculties of economics and management of higher education institutions. Conclusions. Modeling of increasing the agricultural enterprises’ competitiveness and its forward-looking management is based on improving the accounting and evaluation of indicators of its factors and components. Its result can be a three-factor model of competitive space based on the following indicators: the level of competitiveness of products, the level of financial and economic sustainability, the market share size. The key to increasing the competitiveness of agricultural entities depending on the model chosen and strategies of functioning in the market space is called innovation, compliance with specialization, marketing plans.
Features of application of information and communication technologies in the process of teaching economic and mathematical disciplines
Authors: Semenenko Elena , Tsibulya Roman 
Published: April 2021

The article analyzes organization of the educational process of a mixed form related to teaching economic and mathematical disciplines, identifies the didactic potential of information and communication technologies in the organization of educational activities and proposes a pedagogical and organizational model of using information and communication technologies in organizing the educational activities of students of economic specialties in the process of studying economic mathematical disciplines. The subject of the research is the process of organizing the educational activities of students of economic specialties in the study of economic and mathematical disciplines by means of information and communication technologies. The purpose of the work is to find the optimal format for teaching economics and mathematics disciplines, considering the experience of transition to the ubiquitous distance learning form of study and the creation of effective communication between students and teachers, based on existing information technologies. The methodological basis of the article was the following methods: comparative and system analysis, generalization, classification, modeling, substantiation of pedagogical conditions, design of a model for organizing educational activities, observation, expert assessment, self-assessment, conversations, questioning of teachers and students. Results of work. The state of the organization of the educational process of a mixed form is analyzed, the theoretical and existing pedagogical conditions for organizing training in economics and mathematics courses using information and communication technologies are considered. A pedagogical, structural, organizational model for the application of information and communication technologies in the process of studying economic and mathematical disciplines has been developed and measures have been proposed to optimize the learning process. Scope of the results implementation. Theoretical conclusions and practical recommendations of the research can be applied in teaching economics and mathematics at universities in the preparation of specialists in finance, economics and accounting. Conclusions. The quality of teaching economic and mathematical disciplines in a mixed form of education by means of information and communication technologies requires improvement, where information and communication technologies act both as a means and as a teaching method. The proposed organizational and pedagogical model of teaching, in these disciplines, will make it possible to implement an active learning strategy, where the interaction between students and teachers is optimized by means of information and communication technologies.
Democratic Theory and the Empirical Study of Popular Vote Processes
Authors: McKay Spencer 
Published: April 2021

Altman, David. 2018.Citizenship and Contemporary Direct Democracy.Cambridge: Cambridge University Press.Dyck, Joshua, and Edward Lascher. 2019.Initiatives without Engagement: A Realistic Appraisal of Direct Democracy’s Secondary Effects.Ann Arbor, MI: University of Michigan Press.Hollander, Saskia. 2019.The Politics of Referendum Use in European Democracies.London: Palgrave MacMillan.Matsusaka, John G. 2020.Let the People Rule: How Direct Democracy Can Meet the Populist Challenge.Princeton, NJ: Princeton University Press.
Transcriptomic analysis reveals that combinations of vitamins A, D2, and D3 have synergistic effects in HCT-116 colon cancer cells by altering the expression of genes involved in multiple canonical pathways including apoptosis, regulation of the...
Authors: Mahady Gail , Kanabar Pinal , Los Nina , Lawal Temitope , Patel Shitalben , Maienschein-Cline Mark , Arbieva Zarema 
Published: April 2021

Integrated systems biology approaches suggest that combinations of nutrients may be more effective against cancer due to the large number of signaling pathways associated with cancer initiation and promotion. In a previous work, we have reported that combinations of vitamins A (as all trans-retinoic acid, ATRA), D2, and D3 act synergistically to induce apoptosis in colon and gastric cancer cells. In this work, we use whole-genome transcriptomic profiling to detect gene expression changes using RNA-seq to more comprehensively investigate the biological pathways affected by the combination of vitamin D2, D3 and ATRA. HCT-116 colon cancer cells were harvested, RNA was isolated and RNA-seq libraries were prepared using a Universal Plus mRNASeq kit. Sequencing was carried out on NovaSeq 6000. General quality-control metrics were obtained using FastQC and raw reads were aligned to human reference genome hg38 using STAR and BWA MEM. ENSEMBL genes were quantified using FeatureCounts, and differential expression statistics were computed using EdgeR. Specific gene expression was validated using qPCR. Transcriptomic analysis showed that of 26,313 genes analyzed, the expression of 8,402 genes was significantly altered (4030 up-regulated and 4373 down-regulated, FDR<0.05) in the treated cells, of which, 3,621 genes were differentially expressed (fold change <-1 or >+1 and an FDR <0.05). IngenuityÒ Pathway analysis revealed the involvement of 97 canonical pathways, with the top pathways including: mechanisms of cancer, apoptosis, myc-mediated apoptosis, regulation of the epithelial mesenchymal transition, and immunity. Keywords: apoptosis, cholcalciferol, colon cancer, caspase, CRMP1, ergocalciferol, IL-12, NOTCH1, RNA-seq, SMAD7, synergism, transcriptome
MACRO FACTORS INFLUENCING THE FORMATION OF STANDARDIZED MANAGEMENT SYSTEMS OF AN ENTERPRISE
Authors: Olena Gorlova  
Published: April 2021

This article is devoted to the environmental factors, influencing the implementation of standardized management systems of the enterprise at the country level. The problem is considered from the perspective of systems theory and complexity theory. The research focuses on management systems created following ISO 9001 and ISO 14001 standards and their relationship with the external environment. The study involved 20 European countries with different levels of economic and innovative development. The formation and subsequent development of standardized management systems (SMSs) require considering environmental factors, the context of the enterprise, which is reflected in the provisions of standards for management systems. However, the issues of the influence of environmental factors on the decision of enterprises to implement standardized management systems have been insufficiently studied. The work contains three hypotheses: a) about the connection between environmental factors and the introduction of SMSs by enterprises; b) about the diversity and uniqueness of the configurations of environmental factors affecting the spread of the SMSs in different countries; c) regarding the presence of similar structures of environmental factors influencing the spread of the SMSs in separate countries, which would make it possible to identify the basic types of such configurations. The study resulted in confirmation that a connection between environmental factors on the implementation of the SMSs exists, and groups of aggregated factors along with their components were identified. The features of the configurations of factors influencing the SMSs in different countries were considered. A distinctive type of influence of the external environment on the SMSs board, common for several European countries, was revealed, and called as ‘denying’. Correlation analysis was used to determine the relationship between the factorial and the resulting characteristics, the results of which were subjected to qualitative discussion. Further research in this direction should cover a larger number of countries and factors influencing the formation of the SMSs. This will allow identifying a greater number of basic types of external environment influence on the formation of SMSs for enterprises in different countries and regions
THE OPPORTUNITIES AND BENEFITS OF OPEN BANKING IMPLEMENTATION
Authors: Mariia Lutsyk  
Published: April 2021

The technological innovations help improve and develop online payments, including digital wallets, P2P payments, and e-commerce payments through existing e-banking infrastructure. Privacy issues prevent data owners to share them outside their institutions for fear of fraud and abuse. Open banking can help maximize customer benefits through data sharing and deeper collaboration between financial institutions. All companies providing payment services in the European Economic Area must comply with the PSD2 account access requirements. PD2 regulates that third-party PSPs have the right to access a payment account held with banks to provide account information services and / or payment initiation services. To do this, banks must provide a secure and open interface for third-party payment systems for account access, reporting and payment initiation. In light of the update of the European Commission's Payment Services Directive, which aims to improve competition and boost economic activity by facilitating and encouraging bank account holders to send their account data in a controlled and secure manner, there is a problem with customers' lack of awareness, benefits and security. Time of operations on the principles of open banking. This study is devoted to the study of the concept of Open Banking, its economic nature, prerequisites, opportunities and risks of implementation as a new way to use payment services, introduced by the directive. The research contributes to the development of open banking technology and solves the problem raised in the work - the trust of customers in it, which determines the success of its implementation and development of such a business model.
Spór o korporacyjną (spółdzielczą), obligacyjną, czy mieszaną naturę prawną spółdzielczych stosunków mieszkaniowych w prawie polskim na tle prawa niemieckiego
Authors: Piotr Zakrzewski  
Published: April 2021

Artykuł dotyczy problematyki natury prawnej stosunków prawnych między spółdzielnią mieszkaniową a członkiem wynikającą z umów o budowę oraz o ustanowienie spółdzielczego lokatorskiego prawa do lokalu mieszkalnego. Mogą one mieć potencjalnie korporacyjną (spółdzielczą), obligacyjną lub mieszaną naturę prawną. Zasadniczo spór dotyczy tego, czy są to swoiste stosunki prawne unormowane przez przepisy prawa spółdzielczego, które różnią się od typowego stosunku obligacyjnego i nie mogą być z nim w pełni utożsamiane, czy przeciwnie są to typowe stosunki obligacyjne. Problematyka ta pojawiał się już w polskim piśmiennictwie i orzecznictwie w latach sześćdziesiątych XX w. za sprawą dwóch glos – Z. Radwańskiego i J. Ignatowicza. Pierwszy z nich opowiedział się za tym, że stosunki między spółdzielnią mieszkaniową, a członkiem są stosunkami obligacyjnym, a drugi przeciwnie uznał, że są to szczególne (swoiste) stosunki prawne unormowane przez przepisy prawa spółdzielczego, które różnią się od typowego stosunku obligacyjnego i nie mogą być z nimi utożsamiane. Problematyka ta nie doczekała się jednak rozstrzygnięcia i taką pozostaje także współcześnie, pomimo swojego teoretycznego i praktycznego znaczenia. Problematyka ta stanowiła natomiast przedmiot ożywionego zainteresowania w piśmiennictwie niemieckim. Do poglądów tam wyrażanych ze względu na ich wagę i znaczenie niniejszy artykuł nawiązuje. Kluczowe w mojej ocenie dla dalszych rozważań w tym zakresie ma czynione w niemieckim piśmiennictwie rozróżnienie między wolnością umów, a wolnością zakładania zrzeszeń (Vereinigungsfreiheit). Kluczowe znaczenie ma więc, która z tych wolności stoi u podstaw stosunków prawnych między spółdzielnią, a członkiem. Dalsza część artykułu mieści omówienie argumentów kluczowych przy ocenie natury omawianych prawnej stosunków prawnych, np. podwójna pozycja członka, jako udziałowca spółdzielni mieszkaniowej i strony stosunków prawnych, zależność organizacyjna, powiązanie z członkostwem. Artykuł wieńczą wnioski, z których wynika, że omawiane stosunki cechują się spółdzielczą specyfiką. Konsekwencją tego jest m.in. niemożność uznania uchwał organów spółdzielni kształtujących wysokość opłat za wzorce umowne z kodeksu cywilnego.
Doręczenie korespondencji pozwanemu przez komornika sądowego. Zagadnienia wybrane. Problemy praktyczne.
Authors: Joanna Szachta  
Published: April 2021

Art. 1391 k.p.c. stanowi istotne novum, bowiem wcześniej nie obowiązywało w procedurze cywilnej podobne rozwiązanie. Wskazano, jak kształtować się będzie wspomniana regulacja w aspekcie doręczenia pisma przez komornika sądowego. Zwrócono uwagę na wysokość opłaty oraz sprzeczność pomiędzy ustawowym terminem na dokonanie doręczenia przez organ egzekucyjny a ustawowym terminem na wniesienie opłaty. Podniesiono, w jaki sposób komornik dokonuje doręczenia oraz jak będzie ustalony - w przypadku bezskuteczności doręczenia – adres pozwanego. Następnie wskazano na problemy wynikające z nowej regulacji, m.in. szeroki katalog osób, które mogą zostać upoważnione przez komornika do dokonania czynności doręczenia. Sformułowano warunki, które powinny spełniać osoby upoważnione przez komornika do doręczeń. Zwrócono uwagę na aspekt niemożności ustalenia miejsca pobytu pozwanego przez komornika, a także rozważono, czy komornik może czerpać wiedzę na temat adresu pozwanego z innych prowadzonych postępowań. Zaznaczono, że nowa regulacja prowadzi do przedłużenia postępowania rozpoznawczego. Sformułowano proponowane brzmienie przepisów dotyczących doręczeń. Zaproponowano wprowadzenie bazy adresów korespondencyjnych pełnoletnich obywateli, w celu przyspieszenia postępowania i zerwania z fikcją doręczeń.
THE CONDITION OF THE HARD TISSUES OF THE TEETH IN CHILDREN WITH ACUTE FORMS OF LEUKEMIA
Authors: Lehenchuk О.V. , Plyska O.N. 
Published: April 2021

Relevance. Children with oncohematological pathology have a high level of dental diseases since the use of high doses of cytostatic drugs leads to damage to the hard tissues of the teeth. In recent years, the number of children with acute leukemia has increased in Ukraine from 2.5 to 4.1 cases per 100,000 child population.
Objective: to study the indicators of the intensity of caries of temporary and permanent teeth in children with acute forms of leukemia: lymphoblastic and myeloblastic.
Materials and methods. Clinically examined 98 children aged 2-18 years, with acute forms of leukemia. The examined children were divided into groups: the first group – 61 children with acute lymphoblastic leukemia, and the second – 37 children with acute myeloblastic leukemia. Served as control 63 practically healthy children. The analysis of the structure of the constituent elements of the indicators of the intensity of decay teeth caries (df) in children 2-5 years old and caries of permanent teeth (DMF) in children 6-18 years old was performed. The constituent elements of the df indicator are "d" – decayed tooth that is subject to treatment, "f" – filled teeth. The constituent elements of the DMF indicator are "D" – decayed tooth that is subject to treatment; "F" – filled teeth; "M" – missing teeth.
Results. When studying the intensity of caries of temporary and permanent teeth in children with acute lymphoblastic leukemia, it was found that in children 2-5 years old, cf is equal to 6.64 affected teeth per child. In this case, the "d" element was 75.30%, compared with the control group of children, where the "f" element was 45.28%. Element "f" was 24.6%, and in the control group, it was significantly higher and was equal to 54.92%. In children with acute lymphoblastic leukemia 6-18 years old, the DMF is 5.34 teeth. At the same time, the "D" element was 53.13%, and in the control group – 11.06%. Element "F" was 44.24%, in the control group – 85.9%. Element "M" in the main group was equal to 2.63%.
When studying the intensity of caries in temporary and permanent teeth in children with acute myeloid leukemia, it was determined that in children 2-5 years of age, df is equal to 6.25 affected teeth per child. In this case, the "d" element was 80.64%, in comparison with the control group, where the "d" element was 45.28%. Element "f" was 19.36%, and in the control group, it was significantly higher and equal to 54.92%. In children 6-18 years old, the DMF is 5.53 teeth. At the same time, the element "D" in the main group was 41.5%, and in the control group – 11.06%. Element "F" was equal to 57.8%, in the control group - 85.94%. Element "M" in the main group was equal to 0.6%.
Conclusion. Children with acute forms of leukemia have high rates of caries intensity in temporary and permanent teeth.
PATOGENETIC ASPECT OF STUDYING INFLAMMATORY COMPLICATIONS AFTER A TOOTH EXTRACTION OPERATION. Review
Authors: Malanchuk V.O. , Topchiі D.V. , Javadiasl A. 
Published: April 2021

Relevance. Inflammation of the socket of the removed tooth is one of the most frequent complications (from 3 to 40%) of the tooth extraction operation. The lack of consensus on the causes of alveolitis and the lack of an established key role of one of the many diverse factors in the pathogenesis of its development make it difficult to carry out effective preventive measures to prevent its development.
Objective: To use the literature data to summarize and systematize a variety of views on the etiology, pathogenesis, methods of prevention, and treatment of alveolitis.
Materials and methods. The available literary scientific sources are analyzed where modern views on the problems of treating alveolitis are examined. Modern approaches to understanding the etiology, pathogenesis, prevention, and treatment of alveolitis are generalized and systematized.
Results. Most authors, analyzing the main causes and accompanying factors of alveolitis, suggest for its prevention: reduce the traumatic nature of the operation, observe aseptic and correct appointments in the postoperative period, and optimize the healing processes of the well using locally diverse medications.
Conclusion. The prevention of inflammatory complications after the tooth extraction operation is mainly based on the desire to ensure the formation in the tooth socket of a stable blood clot, which should ensure normal regeneration of damaged tissues.