bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemocromatosis y rendimiento deportivo: una revisión sistemática
Authors: Ortega Paloma Martínez , Benítez-Porres Javier 
Published: March 2021

Introducción: la hemocromatosis hereditaria, al provocar hiperferritinemia, puede tener el potencial de aumentar la capacidad aeróbica y el rendimiento deportivo en atletas. Sin embargo, diversos estudios afirman que la sobrecarga de hierro podría afectar negativamente al rendimiento físico y la función muscular.
Objetivo: recopilar y analizar evidencias sobre la relación entre la hemocromatosis hereditaria y el rendimiento deportivo.
Método: Se realizó una revisión sistemática, de acuerdo a los estándares PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), en las siguientes bases de datos: Scopus, Web of Science, PubMed y Dialnet.
Resultados: tras aplicar los criterios de inclusión/exclusión, 13 artículos fueron incluidos y analizados.
Conclusiones: Existen variaciones en los genes que están relacionados con el estado de resistencia del atleta. Actualmente, el gen HFE no se sitúa entre los polimorfismos del ácido desoxirribonucleico que aumenten el rendimiento deportivo. Son mayoría las investigaciones en las que recalcan la necesidad de evaluar el estado de ingesta de hierro en el deportista.
El método Pilates es eficaz en el tratamiento para el abordaje terapéutico del dolor lumbar crónico. Una revisión sistemática
Authors: Munuera Jiménez Francisco Javier , Corral Moreno Vanesa , Juárez Díaz Esther , Cascos Vicente Laura , Rodríguez Almagro Daniel , Obrero Gaitán Esteban , Ibáñez Vera Alfonso Javier 
Published: March 2021

Objetivos: Revisar la literatura más actual para comprobar la efectividad del método Pilates en el dolor lumbar crónico respecto a su efectividad, duración y dosimetría.
Métodos: Se realiza una búsqueda bibliográfica de ensayos clínicos publicados en los últimos cinco años en las bases de datos de Medline, Scopus y PEDro. De 257 estudios hallados, diez son seleccionados atendiendo a los criterios de inclusión y exclusión, siendo posteriormente evaluados en base a la calidad metodológica mediante la escala PEDro.
Resultados: El método Pilates reduce la sintomatología asociada al dolor lumbar crónico a corto plazo, no siendo superior a otros programas activos. Su aplicación en máquinas parece ser más efectiva. Actualmente, no existe consenso respecto a su dosimetría y su efectividad a largo plazo.
Conclusiones: El método Pilates puede ser efectivo a corto plazo para el abordaje terapéutico del dolor lumbar crónico, sin embargo, no ha demostrado ser superior a otros programas de ejercicios activos.
NEWSPAPERS EFFECT ON STUDENTS’ WRITING ACHIEVEMENT ACROSS ENGLISH PROFICIENCY LEVELS
Authors: Amelia Rizky , Muthim Abdul 
Published: March 2021

Exposure is one of the obvious obstacles in the process of teaching and learning English. In figuring out one prospective exposure in students’ daily life, this study investigates the effect of newspapers as a medium in enhancing students’ English achievement, especially writing skill. The objective of this study is to find out whether students assigned to read English newspapers write better than those who are not. The subjects of the study were 85 English department students who were randomly assigned to an experimental group and a control group. A quasi-experimental was employed in this study. For six executive weeks, before the students were asked to write, the students in the experimental group were assigned to read English newspapers, whereas then students in the control group were not. By using Mann-Whitney and one-way ANOVA tests, the results of this study show insignificant results (0, 273; 0,194; and 0,179). As the high proficient students also could not take the newspapers for their learning benefits, affective and intrinsic factors such as awareness and willingness had to be considered.
ENDOSCOPIC-ASSISTED ADENOIDECTOMY USING COBLATION. IS IT THE GOLD STANDARD?
Authors: Hainăroșie R. , Ștefănescu C. D. , Pantea Stoian Anca , Anghelina F. , Ioniță Irina Gabriela , Pietroșanu Cătălina , Rusescu Andreea , Iana Ruxandra Oana , Zainea V. 
Published: March 2021

Adenoidectomy is one of the most common procedures, especially in the pediatric population. When accurately performed, it can cause significant changes in the quality of life of the patient, with minimum risks. Today, the surgeon has a large variety of surgical technologies available for this intervention, from the classical cold steel technique to the state of the art advancements, such as radiofrequency or coblation. The aim of this paper is to evaluate the advantages that are provided by coblation adenoidectomy, taking into account the duration of the intervention, the safety, and efficacy of the procedure and the postoperative pain. We consider all of these factors to be important, especially considering the difficult choice the surgeon faces in choosing the best technology for each patient.
LATE PRESENTING CONGENITAL DIAPHRAGMATIC HERNIA – A CASE SERIES
Authors: Datu R. C. , Stanciu Olivia , Enache T. , Andriescu M. 
Published: March 2021

With an incidence of 1 to 2500 to 1 to 5000 births, congenital diaphragmatic hernia (CDH) can be a life-threatening condition. In 5-25% of the cases, CDH can present at older ages with non-specific signs and symptoms. The aim of our study was to assess the clinical aspects, the diagnosis and management of the patients with this affliction as well as increase the level of awareness on late-presenting CDH. Five patients older than 1 year of age at the moment of diagnosis of CDH were included in the study. The patients presented either for respiratory symptoms or gastrointestinal one. In all the cases, during initial assess, plain chest or abdominal x-rays were performed leading to the diagnosis of congenital diaphragmatic hernia. After further imaging studies (CT scans, ultrasound) all the patients underwent surgery for defect closure, 3 of them by the classic approach, 1 by laparoscopy and 1 by thoracoscopy. Three patients had left diaphragmatic defect and 2 had an anterior diaphragmatic defect. We extensively present the case of a 14-year-old female patient with a posterolateral diaphragmatic defect, in which gastric necrosis was found during surgery, leading to partial gastric resection and esogastric anastomosis. In this case, the postoperative evolution was critical and thepatient died in the 9th day postoperatively. The evolution of the other 4 patients was uneventful.
Prediction of Sepsis in COVID-19 Using Laboratory Indicators
Authors: Tang Guoxing , Luo Ying , Lu Feng , Li Wei , Liu Xiongcheng , Nan Yucen , Ren Yufei , Liao Xiaofei , Wu Song , Jin Hai , Zomaya Albert Y. , Sun Ziyong 
Published: March 2021

BackgroundThe outbreak of coronavirus disease 2019 (COVID-19) has become a global public health concern. Many inpatients with COVID-19 have shown clinical symptoms related to sepsis, which will aggravate the deterioration of patients’ condition. We aim to diagnose Viral Sepsis Caused by SARS-CoV-2 by analyzing laboratory test data of patients with COVID-19 and establish an early predictive model for sepsis risk among patients with COVID-19.MethodsThis study retrospectively investigated laboratory test data of 2,453 patients with COVID-19 from electronic health records. Extreme gradient boosting (XGBoost) was employed to build four models with different feature subsets of a total of 69 collected indicators. Meanwhile, the explainable Shapley Additive ePlanation (SHAP) method was adopted to interpret predictive results and to analyze the feature importance of risk factors.FindingsThe model for classifying COVID-19 viral sepsis with seven coagulation function indicators achieved the area under the receiver operating characteristic curve (AUC) 0.9213 (95% CI, 89.94–94.31%), sensitivity 97.17% (95% CI, 94.97–98.46%), and specificity 82.05% (95% CI, 77.24–86.06%). The model for identifying COVID-19 coagulation disorders with eight features provided an average of 3.68 (±) 4.60 days in advance for early warning prediction with 0.9298 AUC (95% CI, 86.91–99.04%), 82.22% sensitivity (95% CI, 67.41–91.49%), and 84.00% specificity (95% CI, 63.08–94.75%).InterpretationWe found that an abnormality of the coagulation function was related to the occurrence of sepsis and the other routine laboratory test represented by inflammatory factors had a moderate predictive value on coagulopathy, which indicated that early warning of sepsis in COVID-19 patients could be achieved by our established model to improve the patient’s prognosis and to reduce mortality.
Exploration of a Robust and Prognostic Immune Related Gene Signature for Cervical Squamous Cell Carcinoma
Authors: Zuo Zhihua , Xiong Junjun , Zeng Chuyi , Jiang Yao , Xiong Kang , Tao Hualin , Guo Yongcan 
Published: March 2021

Background: Cervical squamous cell carcinoma (CESC) is one of the most frequent malignancies in women worldwide. The level of immune cell infiltration and immune-related genes (IRGs) can significantly affect the prognosis and immunotherapy of CESC patients. Thus, this study aimed to identify an immune-related prognostic signature for CESC.Methods: TCGA-CESC cohorts, obtained from TCGA database, were divided into the training group and testing group; while GSE44001 dataset from GEO database was viewed as external validation group. ESTIMATE algorithm was applied to evaluate the infiltration levels of immune cells of CESC patients. IRGs were screened out through weighted gene co-expression network analysis (WGCNA). A multi-gene prognostic signature based on IRGs was constructed using LASSO penalized Cox proportional hazards regression, which was validated through Kaplan–Meier, Cox, and receiver operating characteristic curve (ROC) analyses. The abundance of immune cells was calculated using ssGSEA algorithm in the ImmuCellAI database, and the response to immunotherapy was evaluated using immunophenoscore (IPS) analysis and the TIDE algorithm.Results: In TCGA-CESC cohorts, higher levels of immune cell infiltration were closely associated with better prognoses. Moreover, a prognostic signature was constructed using three IRGs. Based on this given signature, Kaplan–Meier analysis suggested the significant differences in overall survival (OS) and the ROC analysis demonstrated its robust predictive potential for CESC prognosis, further confirmed by internal and external validation. Additionally, multivariate Cox analysis revealed that the three IRGs signature served as an independent prognostic factor for CESC. In the three-IRGs signature low-risk group, the infiltrating immune cells (B cells, CD4/8 + T cells, cytotoxic T cells, macrophages and so on) were much more abundant than that in high-risk group. Ultimately, IPS and TIDE analyses showed that low-risk CESC patients appeared to present with a better response to immunotherapy and a better prognosis than high-risk patients.Conclusion: The present prognostic signature based on three IRGs (CD3E, CD3D, LCK) was not only reliable for survival prediction but efficient to predict the clinical response to immunotherapy for CESC patients, which might assist in guiding more precise individual treatment in the future.
Measuring Wasting and Stunting Prevalence Among Children Under 5 Years of Age and Associated Risk Factors in Papua New Guinea: New Evidence From the Comprehensive Health and Epidemiological Surveillance System
Authors: Pham Bang Nguyen , Silas Vinson D. , Okely Anthony D. , Pomat William 
Published: March 2021

Background: Papua New Guinea (PNG) has undergone a significant health transition, with the prevalence of non-communicable diseases increasing. Many children under 5 years of age suffer from the burden of malnutrition. While wasting and stunting still remain high, children who are overweight and obese are reportedly increasing.Objective: This study reports the prevalence of wasting, stunting, underweight, and overweight children under five in PNG and explores potential household and maternal socioeconomic factors associated with malnutrition.Method: Data were drawn from the Comprehensive Health and Epidemiological Surveillance System (CHESS) in PNG. Height and weight were directly measured, and wasting, stunting, overweight, and underweight statistics were determined using the 2006 WHO Standard Growth Standards. Household and maternal factors were assessed with parent interviews conducted by trained data collectors. Multivariate logistic regression analyses were conducted to report associations between selected socioeconomic correlates and child malnutrition outcomes.Result: The prevalence of wasting, stunting, underweight, and overweight children was 13.8, 46.5, 18.2, and 18%, respectively. Children from households with food shortage were more likely to be wasted than those from households without such an experience [OR: 1.43 (95% CI: 0.93–2.21)]. Children from the poor quintile were more likely to be stunted than those from the richest quintile [OR: 1.2 (95% CI: 0.79–1.82)]. Other factors associated with wasting included living in an urban vs. rural area [OR: 1.36 (0.77–2.4)], middle household wealth quintile vs. richest quintile [OR: 0.77 (0.38–1.55)], mothers in union with a man vs. mother unmarried or live in union [OR: 0.76 (0.4–1.42)], and male children vs. female [OR: 0.77 (0.53–1.11)]. Factors associated with stunting included residing in urban vs. rural areas [OR: 1.13 (0.8–1.6)], mother in union vs. single mother [OR: 0.86 (0.59–1.24)], and mothers with preparatory/elementary vs. mothers with vocational/college education [OR: 0.15 (0.02–1.01)].Conclusion: An integrated approach is needed to comprehensively address the household socioeconomic factors at the household level, contributing to the improvement of child health and development in PNG.
Genomic Profiling Identified Novel Prognostic Biomarkers in Chinese Midline Glioma Patients
Authors: Li Hainan , Shan Changguo , Wu Shengnan , Cheng Baijie , Fan Chongzu , Cai Linbo , Chen Yedan , Shi Yuqian , Liu Kaihua , Shao Yang , Zhu Dan , Li Zhi 
Published: March 2021

BackgroundMolecular characteristics are essential for the classification and grading of gliomas. However, diagnostic classification of midline glioma is still debatable and substantial molecular and clinical heterogeneity within each subgroup suggested that they should be further stratified. Here, we studied the mutation landscape of Chinese midline glioma patients in hope to provide new insights for glioma prognosis and treatment.MethodsTissue samples from 112 midline glioma patients underwent next-generation sequencing targeting 425 cancer-relevant genes. Gene mutations and copy number variations were investigated for their somatic interactions and prognostic effect using overall survival data. Pathway-based survival analysis was performed for ten canonical oncogenic pathways.ResultsWe identified several currently established diagnostic and prognostic biomarkers of glioma, including TP53 (33%), EGFR (26%), TERT (24%), PTEN (21%), PIK3CA (14%), ATRX (14%), BRAF (13%), and IDH1/2 (6%). Among all genetic aberrations with more than 5% occurrence rate, six mutations and three copy number gains were greatly associated with poor overall survival (univariate, P &lt; 0.1). Of these, TERT mutations (hazard ratio [HR], 3.00; 95% confidence interval [CI], 1.37–6.61; P = 0.01) and PIK3CA mutations (HR, 2.04; 95% CI, 1.08–3.84; P = 0.02) remained significant in multivariate analyses. Additionally, we have also identified a novel MCL1 amplification (found in 31% patients) as a potential independent biomarker for glioma (multivariate HR, 2.78; 95% CI, 1.53–5.08; P &lt; 0.001), which was seldom reported in public databases. Pathway analyses revealed significantly worse prognosis with abnormal PI3K (HR, 1.81; 95% CI, 1.12–2.95; P = 0.01) and cell cycle pathways (HR, 1.97; 95% CI, 1.15–3.37; P = 0.01), both of which stayed meaningful after multivariate adjustment.ConclusionsIn this study, we discovered shorter survival in midline glioma patients with PIK3CA and TERT mutations and with abnormal PI3K and cell cycle pathways. We also revealed a novel prognostic marker, MCL1 amplification that collectively provided new insights and opportunities in understanding and treating midline gliomas.
Treatment of Residual, Recurrent, or Metastatic Intracranial Hemangiopericytomas With Stereotactic Radiotherapy Using CyberKnife
Authors: Huang Lichao , Bai Jingmin , Zhang Yanyang , Cui Zhiqiang , Zhang Zhizhong , Li Jiwei , Wang Jinyuan , Yu Xinguang , Ling Zhipei , Qu Baolin , Pan Longsheng 
Published: March 2021

PurposeHemangiopericytomas are aggressive tumors known for their recurrence. The purpose of this study was to evaluate the management of residual, recurrent, and metastatic intracranial hemangiopericytomas using CyberKnife (CK) stereotactic radiotherapy (SRT).Materials and MethodsData were collected from 15 patients (28 tumors; eight men and seven women; 32–58 years) with residual, recurrent, or metastatic intracranial hemangiopericytomas, who were treated with stereotactic radiotherapy using CyberKnife between January 2014 and August 2019. All patients had previously been treated with surgical resection. Initial tumor volumes ranged from 0.84 to 67.2 cm3, with a mean volume of 13.06 cm3. The mean marginal and maximum radiosurgical doses to the tumors were 21.1 and 28.76 Gy, respectively. The mean follow-up time for tumors was 34.5 months, ranging from 13 to 77 months.Results15 patients were alive after treatment; the mean post-diagnosis survival at censoring was 45.6 months (range 13–77 months). The volumes of the 28 tumors in the 15 followed patients were calculated after treatment. Postoperative magnetic resonance imaging revealed a mean tumor volume of 6.72 cm3 and a range of 0–67.2 cm3, with the volumes being significantly lower than pretreatment values. Follow-up imaging studies demonstrated tumor disappearance in seven (25%) of 28 tumors, reduction in 14 (50%), stability in one (3.57%), and recurrence in six (21.4%). Total tumor control was achieved in 22 (78.5%) of 28 tumors. The tumor grade and fraction time were not significantly associated with progression-free survival. Intracranial metastasis occurred in three patients, and extraneural metastasis in one patient.ConclusionsOn the basis of the current results, stereotactic radiotherapy using CyberKnife is an effective and safe option for residual, recurrent, and metastatic intracranial hemangiopericytomas. Long-term close clinical and imaging follow-up is also necessary.
Effect of PRM1201 Combined With Adjuvant Chemotherapy on Preventing Recurrence and Metastasis of Stage III Colon Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Jia Ru , Liu Ningning , Cai Guoxiang , Zhang Yun , Xiao Haijuan , Zhou Lihong , Ji Qing , Zhao Ling , Zeng Puhua , Liu Huaimin , Huo Jiege , Yue Xiaoqiang , Zhang Yi , Wu Chaojun , Sun Xiaoting , Feng Yuanyuan , Liu Hongjie , Liu Hui , Han Zhifen , Lai Youying , Zhang Yanbo , Han Gang , Gong Hangjun , Wang Yan , Li Qi 
Published: March 2021

BackgroundChemotherapy is the standard adjuvant treatment for colon cancer. Chinese herbal formula PRM1201 improves the efficacy of chemotherapy when used in combination with Cetuximab or Bevacizumab in patients with metastatic colorectal cancer. This study aims to explore the benefits of treatment with chemotherapy plus PRM1201 in the postoperative adjuvant setting.MethodsIn this parallel-group study, patients who had undergone curative resection for stage III colon cancer were randomly assigned to receive adjuvant chemotherapy (FOLFOX q2w for 6 months, or CapeOx q3w for 6 months) plus PRM1201 (chemo+PRM1201 group) or adjuvant chemotherapy plus placebo (chemo+placebo group). The primary endpoint was disease-free survival (DFS), and the secondary endpoints were quality of life (QOL) and toxicity.ResultsA total of 370 patients were randomly assigned to chemotherapy plus PRM1201 group (n = 184) and chemotherapy plus placebo group (n = 186). Up to October 30, 2019, 96 events of recurrence, metastasis, or death had been reported, of which 38 events were in the group of chemotherapy plus PRM1201 and 58 events in the chemo+placebo group. The 3-year DFS rate was 77.1 and 68.6% in the chemo+PRM1201 and chemo+placebo group, respectively (hazard ratio [HR], 0.63; 95% CI, 0.42 to 0.94). The QOL of patients in the chemo+PRM1201 group were significantly improved in terms of global quality of life, physical functioning, role functioning, emotional functioning, fatigue, and appetite loss. The incidence of grade 3 or 4 treatment-related adverse event (TRAEs) were similar between the two arms.ConclusionsChemotherapy in combination with PRM1201 improved the adjuvant treatment of colon cancer. PRM1201 can be recommended as an effective option in clinical practice.Clinical Trial RegistrationChinese Clinical Trials Registry, identifier ChiCTR-IOR-16007719.
Establishment of a Macrophage Phenotypic Switch Related Prognostic Signature in Patients With Pancreatic Cancer
Authors: Li Mu-xing , Wang Hang-yan , Yuan Chun-hui , Ma Zhao-lai , Jiang Bin , Li Lei , Zhang Li , Xiu Dian-rong 
Published: March 2021

IntroductionMacrophage phenotype switch plays a vital role in the progression of malignancies. We aimed to build a prognostic signature by exploring the expression pattern of macrophage phenotypic switch related genes (MRGs) in the Cancer Genome Atlas (TCGA)—pancreatic adenocarcinoma (PAAD), Genotype-Tissue Expression (GTEx)-Pancreas, and Gene Expression Omnibus (GEO) databases.MethodsWe identified the differentially expressed genes between the PAAD and normal tissues. We used single factor Cox proportional risk regression analysis, Least Absolute Shrinkage and Selection Operator (LASSO) analysis, and multivariate Cox proportional hazard regression analysis to establish the prognosis risk score by the MRGs. The relationships between the risk score and immune landscape, “key driver” mutations and clinicopathological factors were also analyzed. Gene-set enrichment analysis (GSEA) analysis was also performed.ResultsWe detected 198 differentially expressed MRGs. The risk score was constructed based on 9 genes (KIF23, BIN1, LAPTM4A, ERAP2, ATP8B2, FAM118A, RGS16, ELMO1, RAPGEFL1). The median overall survival time of patients in the low-risk group was significantly longer than that of patients in the high-risk group (P &lt; 0.001). The prognostic value of the risk score was validated in GSE62452 dataset. The prognostic performance of nomogram based on risk score was superior to that of TNM stage. And GSEA analysis also showed that the risk score was closely related with P53 signaling pathway, pancreatic cancer and T cell receptor signaling pathway. qRT-PCR assay showed that the expressions of the 9 MRGs in PDAC cell lines were higher than those in human pancreatic ductal epithelium cell line.ConclusionsThe nine gene risk score could be used as an independent prognostic index for PAAD patients. Further studies validating the prognostic value of the risk score are warranted.