bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation and refraction event of complex hyperbolic type solitary wave
in plasma and obtical fiber for the perturbed Chen-Lee-Liu equation
Authors: Yokuş Asıf , Durur Hülya , Duran Serbay 
Published: March 2021

Abstract
In this presented article, modified 1/G'-expansion and modified Kudryashov methods are applied to generate traveling wave solutions of perturbed Chen-Lee-Liu (CLL) equation. The similar and different aspects of the solutions produced by both analytic methods are discussed in the results and discussion section. By giving special values to the constants in the solutions obtained by analytical methods, 2D, 3D and contour graphics representing the shape of the standing wave at any time are presented. Additionally, the advantages and disadvantages of the two analytic methods are discussed and presented in the results and discussion section. Also, a solitary wave is produced by giving special values ​​to the parameters in the hyperbolic type complex traveling wave solution. Simulations are created for different values ​​of the frequency and velocity propagation parameters of the solitary wave. The values ​​of these parameters are calculated for the breakage event physically. A computer package program is used for operations such as solving complex operations, drawing graphics and systems of algebraic equations.
The Potential Value of Plasma Receptor Interacting Protein 3 for Neonatal Sepsis Diagnosis
Authors: Gao Chuchu , Feng Zongtai , Wang Lixia , Zhao Xingxing , Fu Kai , Ma Shurong , Yang Zuming , Wang Sannan , Yu Shenglin 
Published: March 2021

Abstract
Background: Neonatal sepsis is a systemic inflammatory response syndrome in neonates. The molecular mechanism of neonatal sepsis remains incompletely clarified. The purpose of this study was to explore the potential value of receptor interacting protein 3 (RIP3) in neonatal sepsis.Methods: 93 neonates with sepsis and 93 neonates without infectious diseases were enrolled in this study from September 2019 to March 2021. Plasma RIP3 was detected by enzyme-linked immunosorbent assay (ELISA) and assessed along with whole blood hypersensitive C-reactive protein (hs-CRP) and platelet count (PLT). Differences of RIP3, hs-CRP and PLT between the two groups were compared. Changes of the three indicators in sepsis were also observed after treatment. The diagnostic value of indicators for neonatal sepsis was evaluated by receiver operating characteristic (ROC) curve.Results: In sepsis group, RIP3 and hs-CRP levels were significantly higher than those in control group (RIP3, p ＜ 0.0001; hs-CRP, p ＜ 0.0001), and PLT level was significantly lower than that in control group (p＜0.0001). After treatment, RIP3 and hs-CRP levels among septic survivors had a significant decrease (p＜0.0001) and PLT level had a significant improvement (p=0.0028). With RIP3＞15464.72 pg/mL, CRP>3.24 mg/L, PLT<205.00×109 /L as the positive criteria, the sensitivity of the three indicators in the diagnosis of neonatal sepsis was 68.8%, 64.5%, 59.1%, and the specificity was 91.4%, 82.8%, 79.6%, respectively. The combination of RIP3, CRP and PLT showed 76.3% sensitivity and 94.6% sensitivity.Conclusions: RIP3 may attribute to the early diagnosis and understanding therapeutic effect of neonatal sepsis. The combined detection of RIP3, CRP and PLT may be more effective than individual ones in the diagnosis of neonatal sepsis.
Neuroprotection from Stem Cell-Derived Human Adipose Extracellular Vesicles Intranasally Administered 24 Hours After Stroke in Rats.&nbsp;
Authors: Rohden Francieli , Teixeira Luciele Varaschini , Bernardi Luis Pedro , Lukasewicz Pâmela , Colombo Mariana , Teixeira Geciele Rodrigues , Oliveira Fernanda dos Santos de , Lima Elizabeth Obino Cirne , Guma Fátima Costa Rodrigues , Souza Diogo Onofre 
Published: March 2021

Abstract
Ischemic stroke is a major cause of death and disability, demanding innovative and accessible therapeutic strategies. Approaches presenting an optimal period for therapeutic intervention and new treatment administration routes are promising tools for stroke treatment. We evaluated the potential neuroprotective properties of nasally administered human adipose tissue stem cells (hAT-MSCs)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. A single intranasal EV (200 µg/kg) was administered 24 h after a focal permanent ischemic stroke in rats. A higher tropism of EVs was observed in the peri-infarct zone surrounding the infarct core. In the same brain region, there was a significant decrease in the infarct volume, improvement of the blood-brain barrier, and re-stabilization of vascularization. In addition, EVs recovered the impairment of long-term motor and behavioral performance induced by an ischemic stroke. Surprisingly, one single intranasal EVs administration reestablished: i) front paws symmetry, ii) short- and long-term memory, and iii) anxiety-like behavior. In line with the findings, our work highlights hAT-MSC-derived EVs as a promising therapeutic strategy for stroke.
Pancreatic adenocarcinoma up-regulated factor as a target for the treatment of serous ovarian adenocarcinoma
Authors: Kim Yeon Jeong , Park Jin , Jeong Hyeon Hee , Baek Ji Eun , Hong Seung-Mo , Jeong Seong-Yun , Koh Sang Seok 
Published: March 2021

Abstract
Ovarian cancer is the deadliest gynecological cancer and when diagnosed at advanced stages the five-year survival rate is typically less than 30%. Pancreatic adenocarcinoma up-regulated factor (PAUF) plays a crucial role in tumor progression, angiogenesis, and immune evasion in the pancreatic tumor microenvironment. The current study aimed to characterize the potential tumorigenic role of PAUF in serous ovarian cancer as high expression of the factor is correlated with poor prognosis in epithelial ovarian cancer. Extracellular treatment with recombinant PAUF activated intracellular signal pathways that subsequently led to enhanced proliferation, migration, and invasion in various serous ovarian adenocarcinoma cell lines. A PAUF-knockout OVCAR-5 cell line demonstrated an apparent reduction in tumor incidence and delayed tumor growth in mouse xenograft experiments. Furthermore, the administration of an anti-PAUF antibody exhibited a notable therapeutic efficacy in mice bearing the OVCAR-5 cell line-derived xenograft tumors. Taken together, our results suggest that PAUF plays a role in the progression of serous ovarian adenocarcinoma and may serve as a novel therapeutic target of the disease.
Inanimate Objects and the Environment Are Far From Contributing to COVID-19 Spread
Authors: Rocha Ana Luiza Silva , Pinheiro Josilene , Nakamura Thamilin Costa , Silva José Domingos Santos da , Rocha Beatriz Gonçalves Silva , Klein Raphael Contelli , Birbrair Alexander , Amorim Jaime Henrique 
Published: March 2021

Abstract
It is not clear if COVID-19 can be indirectly transmitted. It is not possible to conclude the role of environment in transmission of SARS-CoV-2 without studying areas in which people transit in great amounts, such as market areas. In this work we aimed to better understand the role of environment in the spread of COVID-19. We investigated the presence of SARS-CoV-2 in inanimate objects as well as in the air and in the sewage using RT-qPCR. We studied both, a reference market area and a COVID-19 reference hospital at Barreiras city, Brazil. We collected and analyzed a total of 268 samples from mask fronts, cell phones, paper moneys, card machines, sewage, air and bedding during the ascendant phase of the epidemiological curve of COVID-19 in Barreiras. As a result, we detected the human RNAse P gene in most of samples, which indicates the presence of human cells in specimens. However, we did not detect any trace of SARS-CoV-2 in all samples analyzed. To rule out the possibility of problems in sampling method we tested detection of SARS-CoV-2 by RT-qPCR in laboratory conditions to reproduce environmental temperature and humidity. As a result, we showed detection of the virus in different conditions. We conclude that our sampling method reliable and that, strikingly, the environment and inanimate materials do not have an important role in COVID-19 transmission.
Antifreezing ionotronic skin based on flexible, transparent, and tunable ionic conductive nanocellulose hydrogels
Authors: Zhu Enwen , Xu Haiyu , Xie Yuanyuan , Song Yiheng , Liu Dongning , Gao Yujiao , Shi Zhuqun , Yang Quanling , Xiong Chuanxi 
Published: March 2021

Abstract
Ionic hydrogels with excellent flexibility and good conductivity have great potential in diverse electric devices. However, it remains challenging to improve the biocompatibility of ionic hydrogels. Here, natural and environment-friendly cellulose nanofiber hydrogels were prepared without adding any organic active materials. The cellulose hydrogel networks with free metal ions (Li+/Ca2+/K+) were obtained by soaking in ion aqueous solution of different concentrations in order to endow tunable conductivity, thus a new kind of transparent ionic hydrogels with both excellent sensing performance obtained by a simple, low-cost and harmless process. The free metal ions locked in the negatively charged nanocellulose network through electrostatic interaction provided adjustable conductivity and sensing performance. Hydrogels doped with 4 mol L− 1 lithium ions exhibited the best sensing performance with the conductivity of 4.36×10− 4 S cm− 1, and the current response value was as high as 127%. It was worth noting that the strain-sensitive performance of calcium ions was generally excellent even at low temperatures (-30°C). The antifreezing of the hydrogel improved its service under extreme environment. This kind of hydrogel has great application prospects in artificial intelligence products, such as human healthy monitoring equipment and soft robotics at subzero temperature.
Association of gene polymorphisms in MYH11 and TGF-β signaling with the susceptibility and clinical outcomes of Debakey type Ⅲ aortic dissection
Authors: Chang Yafei , Yuan Qinghua , Jiang Peipei , Sun Ling , Ma Yitong , Ma Xiang 
Published: March 2021

Abstract
Background: Myosin heavy chain 11 (MYH11) and transforming growth factor-β (TGF-β) signaling-related genes as the regulation of the structure and function of vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of aortic dissection (AD). This study aims to investigate the association of MYH11 and TGF-β signaling-related gene polymorphisms with the susceptibility of DeBakey type III AD and its clinical outcomes. Methods: A total of 159 patients with DeBakey Ⅲ AD and 305 healthy subjects were enrolled in this study. 4 SNPs (MYH11 rs115364997, rs117593370, TGFB1 rs1800469 and TGFBR1 rs1626340) were selected and analyzed. GMDR was used to evaluate gene-gene and gene-environment interactions. Patients were followed up for a median of 55.7 months. Results: MYH11 rs115364997 G carriers (OR = 1.629; 95%CI: 1.077-2.462, P = 0.020) or TGFBR1 rs1626340 A carriers (OR = 1.500; 95CI: 1.032-2.181, P = 0.033) had a higher risk of DeBakey type Ⅲ AD. MYH11, TGFB1, TGFBR1, and environment interactions are contribute to DeBakey type Ⅲ AD risk (CVC=10/10, P = 0.001). Dominant models of MYH11 rs115364997 AG+GG genotype (HR = 2.443; 95%CI:1.096-5.445, P = 0.029), TGFB1 rs1800469 AG+GG (HR = 2.303; 95%CI:1.069-4.96, P = 0.033) were associated with a higher risk of mortality in DeBakey type III AD. TGFB1 rs1800469 dominant model AG+GG genotype was associated with a higher risk of recurrence of chest pain in DeBakey type III AD (HR = 1.566; 95%CI: 1.018-2.378, P = 0.041). Conclusions: This study indicated that variations of MYH11 rs115364997 and TGFBR1 rs1626340 are associated with genetic predisposition of DeBakey type III AD. G carriers of MYH11 rs115364997 or TGFB1 rs1800469 may be the poor prognostic indicators of mortality and recurrent chest pain in DeBakey type III AD. The interactions of gene-gene and gene-environment are associated with the risk of DeBakey type III AD.
Mutation based Atom Search Optimization Algorithm for Hyperparameter Optimization of the DenseNet121 Architecture for Cervical Cancer Classification
Authors: Chitra B , Kumar S.S. 
Published: March 2021

Abstract
The cervical cancer patient’s death rate can be minimized by accurate and early detection of cervical cancer (CC). One of the popular techniques called the Pap test or Pap smear is widely used for the early detection of CC. The manual analysis consumed more time in the case of CC detection. The existing techniques met few shortcomings in terms of poor accuracy, more computational complexity, higher feature dimensionality, poor reliability, and higher time-consumption with poor hyperparameters optimization. Hence, the computer-aided diagnostic model provides reliable and accurate CC detection at the initial stage. In this paper, we proposed MASO optimized DenseNet 121 architecture for the early detection of cervical cancer. At first, different kinds of augmentation techniques such as horizontal flip, vertical flip, zooming, shearing, height shift, width shift, rotation, and brightness to increase the number of training samples. The Mutation based Atom Search Optimization (MASO) algorithm is established to optimize the hyperparameters in DenseNet 121 architecture suchnumber of neurons in the dense layer, learning rate value, and the batch sizes. Different kinds of performance metrics such as accuracy, specificity, sensitivity, precisions, recall, F-score, and confusion matrix evaluate the performance of MASO optimized DenseNet 121 architecture for CC detection. A single normal class with three abnormal classes namely Carcinoma, Light dysplastic, and Sever dysplastic were selected from the Hervel dataset for experimental investigation. The proposed MASO optimized DenseNet 121 architecture achieves 98.38% accuracy, 98.5% specificity, 98.83% sensitivity, 98.58% precision, 99.3% recall and 98.25% F-score values than other existing methods.
Global Evidence on the Rapid Adoption of Telemedicine in Primary Care During the First Year of the COVID-19&nbsp;Pandemic: a Scoping Review Protocol.
Authors: Valdes Daniela , Alqazlan Lama , Procter Rob , Dale Jeremy 
Published: March 2021

Abstract
Background: Before the declaration of the COVID-19 pandemic in March 2020, primary care relied on face-to-face consultations, with relatively limited use of telemedicine. The rapid uptake that occurred following the onset of the pandemic in countries such as the United Kingdom, Canada and New Zealand prompts questions around the drivers and extent of this transformation in clinical practice at global level. The purpose of this scoping review is to explore the global evidence surrounding the rapid adoption of telemedicine in primary care settings during the first year of the COVID-19 pandemic. Methods: A draft protocol was tested through an initial search on Ovid Medline, Web of Science and Google Scholar with additional searches on the Cochrane Database. This informed the final selection of terms which will be use to search Ovid, Web of Science, Google Scholar, PROSPERO and Cochrane Library, filtering for studies from the pandemic declaration onwards. Additional grey literature reports will be sourced through simplified searches on appropriate search engines in widely spoken languages. Duplicates will be removed by screening titles. Abstracts and grey literature text extracts will be screened based on pre-set eligibility criteria by an automated tool and further screened by the lead researcher. Abstracts (and extracts in the case of grey literature) will be mapped against the domains of the Non-adoption, Abandonment, and challenges to Scale-up, Spread and Sustainability (NASSS) framework. Data will be presented in table format. Discussion: This review will map the current literature to identify current gaps in evidence related to the adoption of telemedicine after the declaration of the pandemic in March 2020. The use of simplified searches in the most spoken languages in the world is aimed at capturing more immediate non-academic reflections and experiences on this major service change at a global level.Systematic review registration: Study has been registered on Open Science Framework and can be accessed through the following URL: https://osf.io/4z5ut/
Radiation Modification and Characterization of Polyvinyl alchohol/Starch/Citric Acid/Glycerol Bioblend Film
Authors: Ghaffar Ashraf M. Abdel , Ali H. E. 
Published: March 2021

Abstract
The blending of polyvinyl alcohol (PVA) with starch with different content of citric acid as crosslinker and glycerol as plasticizer were performed by casting method. The hydroxyl groups of PVA and Starch react with the citric acid (1 %) and glycerol (10 vol %) to form crosslinked network. The FTIR spectral analyses show the successful preparation of the different composition of the prepared PVA/ Starch /Citric acid/Glycerol bioblend films. It is found that the prepared PVA/ Starch /Citric acid/Glycerol with composition (2:1:1/10 vol %) bioblend film characterized by higher water resistance, good mechanical and higher thermal stability than other prepared bioblend films. The using of gamma radiation improved and modified water resistance property were the water uptake at equilibrium reduced remarkably at dose of 10 kGy. Also the thermal stability increased as irradiation dose increased up to dose of 30 kGy The improved mechanical and thermal properties of the selected PVA/ Starch /Citric acid/Glycerol with composition (2:1:1/10 vol %) bioblend film were compared with LDPE and PP packaging films and found to be competitive to the these commercially packaging films which are also nonbiodegradable synthetic polymers than the prepared selected PVA/ Starch /Citric acid/Glycerol with composition (2:1:1/10 vol %) bioblend film. Hence this study can be represent potential development of low cost-effective and modified PVA/ Starch /Citric acid/Glycerol with composition (2:1:1/10 vol %) bioblend film that characterized by several advantages over the commercially available petrochemical films and can be used in different applications such as packaging industry.
A Questionnaire-based Study to Comprehensively Assess the Status Quo of Rare Disease Patients and Care-givers in China
Authors: Li Xuefeng , Liu Meiling , Li Bingzhe , Zhang Xiangyu , Zhang Shu , Lu Zijuan , Zhang Jianyong , Zhou Jincheng , Ou Li 
Published: March 2021

Abstract
Background: There are over 16.8 million rare disease patients in China, representing a large community that should not be neglected. To provide a basis for policy-makers to better understand the status quo of rare disease patients and care-givers in China and to devise some new policies, a comprehensive analysis of the status quo, unmet needs, difficulty caused by the rare disease is essential.Methods: A questionnaire-based study of patients and care-givers (usually family members) was performed. The questionnaire was composed of 116 questions, such as the diagnosis process, treatment access, financial burden, views on patients’ organizations, and a series of standardized tests to assess the quality of their life, including the SF-36, PHQ-9, PHQ-15, GAD-7, and PSQI. To examine the influence of age, disease type, and relationship to patients on the scores in these tests, statistical analysis with a general linear model was conducted.Findings: A total of 1,959 patients and care-givers participated in the survey, representing 104 rare diseases, such as lysosomal storage diseases, hemophilia, and muscular dystrophy diseases. The diagnosis was delayed for 1.4 ± 3.0 years, and patients experienced 1.6 ± 3.8 misdiagnoses between 3.2 ± 2.4 hospitals. The hospitals where diagnoses were made were highly concentrated in 10 large hospitals (43.8%) and 5 big cities (42.1%), indicating a significant inequality of medical resources. The disease often led to difficulty in social life, education, and employment, as well as financial burden that was seldom covered by medical insurance. A battery of standardized tests demonstrated poor health status, depression, somatization, anxiety, and sleeping issues among both patients and care-givers (p<0.05).Statistical analysis of the questionnaire also showed that poor health, anxiety, depression, somatization, and sleeping problems were more prevalent in patients than in care-givers, and more prevalent in more severe diseases (e.g., hemophilia, Dravet) or undiagnosed than in other diseases.Interpretations: This study identified the lack of rare disease awareness and legislative support as the major challenge to rare diseases in China, and makes key recommendations for policy-makers, including legislating orphan drug act, raising rare disease awareness, and protecting rights in education and employment.
Synchronisation Conditions for a Class of Non-linearly Coupled Networks using Contraction Based Strategy
Authors: CHAUHAN YASHASVI , Sharma Bharat Bhushan 
Published: March 2021

Abstract
This paper describes a simple and general framework for synchronisation of non-linearly coupled dynamical systems interconnected to constitute a com- plex network. The proposed methodology of attaining synchronisation of networks is based on contraction strat- egy. The paper introduces a systematic control proce- dure to achieve synchronisation of a coupled dynamical network of proposed strict-feedback like class of nonlin- ear systems. The non-linear coupling function between different systems of the network is assumed to be in the form of bidirectional links. The proposed method- ology can be applicable to any arbitrarily structure of linear/non-linear, bidirectional or unidirectional N- coupled systems in a network. The general results have been derived for coupled systems interacting through nonlinear coupling function which are interconnected in different networked topologies including Ring, Global, Star, Arbitrary etc. The analytical conditions for syn- chronisation are expressed in terms of bounds on cou- pling strength which are derived using partial contrac- tion concepts blended with graph theory results. The proposed approach is straightforwardly applied to high dimensional non-linearly coupled chaotic systems which are common in many applications. A set of representa- tive examples of coupled chaotic systems based network are simulated to verify the theoretical results.