bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focal Unspecific Bone Uptake on [18F]-psma-1007 Pet: A Multicenter Retrospective Evaluation of the Distribution, Frequency, and Quantitative Parameters of a Potential Pitfall in Prostate Cancer Imaging
Authors: Grünig Hannes , Maurer Alexander , Thali Yannick , Kovacs Zsofia , Strobel Klaus , Burger Irene A. , Müller Joachim 
Published: March 2021

Abstract
PurposeImproved logistics and availability led to a rapid increase in the use of [18F]-PSMA-1007 for prostate cancer PET imaging. Initial data suggests increased uptake in benign lesions compared to [68Ga]-PSMA-11, and clinical observations found increased unspecific bone uptake (UBU). We therefore investigate the frequency and characteristics of UBU in [18F]-PSMA-1007 PET.MethodsWe retrospectively analyzed [18F]-PSMA-1007 PET scans from four centers for the presence of UBU, defined as a focal mild-to-moderate uptake (SUVmax < 10.0) not obviously related to a benign or malignant cause. If present, up to three leading UBUs were quantified (SUVmax), localized, and correlated to clinical parameters, such as age, PSA, injected dose, Gleason-score, tumor size (T1–T4), and type of PET scanner (analog vs. digital). Additionally, clinical and imaging follow-up results and therapeutic impact were evaluated.ResultsUBUs were identified in 179 out of 348 patients (65.2%). The most frequent localizations were ribs (57.5%) and pelvis (24.8%). The frequency of UBUs was not associated with PSA, Gleason-score, tumor size, age, or the injected [18F]-PSMA-1007 dose. UBUs were significantly more frequent in images obtained with digital scanners (70.1%) than analog scanners (p=.0001). In 80 out of 179 patients (44.7%), the interpretation of UBUs was critical for therapeutic management and therefore considered clinically relevant. For 65 UBUs, follow-ups were available: three biopsies, three radiotherapies with PSA follow-up, and 59 cases with imaging. After follow-up UBUs were still considered unclear in 28 of 65 patients (43.1%), benign in 28 (43.1%), and malignant in nine (13.8%) patients.ConclusionUBUs occur in two-thirds of patients imaged with [18F]-PSMA-1007 PET/CT and are significantly more frequent on digital PET scanners than analog scanners. UBUs should be interpreted carefully to avoid over-staging.
The influence of exocyclic lone pairs on the bonding and geometry of type A mesoionic rings
Authors: Ramsden Christopher Antony , Oziminski Wojciech Piotr 
Published: March 2021

Abstract
Based on structures determined by X-ray crystallography, ab initio MP2 calculations on type A mesoionic rings give geometries in good agreement with observed values. A study of four mesoionic ring systems, each with exocyclic oxygen, nitrogen or carbon groups, shows that the presence and configuration of exocyclic lone pairs significantly influences the geometry and configurational preference. Using a localised bond model, these effects are rationalised in terms of an anomeric interaction of lone pairs with the antibonding orbitals of adjacent σ bonds. In agreement with experiment, similar effects are calculated for pyran-2-imines.
Predictive Evaluation of Quantitative Spatial Profiling of the Tumor Microenvironment by Multiplex Immunofluorescence in Recurrent Glioblastoma Treated with PD-1 Inhibitors
Authors: Cieremans David Alexander , Kim Ju Young , Valencia Ariana , Santos Justin , Bordeaux Jennifer , Tran Thai , Vaupel Christine , Dakappagari Naveen , Tangri Shabnam , Iwamoto Fabio 
Published: March 2021

Abstract
Introduction: PD-1 inhibitors have shown limited efficacy in glioblastoma due to microenvironment immunosuppression and low tumor mutational burden. In GBM, PD-L1 expression is not a predictive marker for response to PD-1 or PD-L1 inhibitors. Multiplex immunostaining panel technology allows for detailed analyses of tumor microenvironment cells and their interaction. Methods: Pre-treatment tumor tissue was collected retrospectively from 27 patients at Columbia University Irving Medical Center with primary glioblastoma who were diagnosed within the past three years, had surgery here, and were either treated with SOC therapy (n= 8) or PD-1 inhibitors at recurrence (n= 19). Multiplex immunofluorescence panels included 1) CD11b/IDO1/HLADR/GFAP, 2) PD1/PD-L1/GFAP, and 3) CD4/CD8/CD25/FoxP3/Ki67/GFAP. Results: Multiplex immunofluorescence panels did not show any correlation with outcomes in patients treated with SOC therapy. Among the 19 patients treated with PD-1 inhibitors, those with more HLA-DR positive cells had worse outcomes (p= 0.02). PD-L1 expression on tumor cells was not predictive of outcomes. There was a correlation trend between PD-1/PD-L1 interaction score (p= 0.08) and outcomes. PTEN loss was correlated with higher Ki67 expression in both tumor cells (p= 0.05) and non-tumors cells (p= 0.03); however, this was not found in Ki67 in CD4+ cells, CD8+ cells, or CD4+CD8+ cells combined. Tumor-associated macrophages, myeloid-derived suppressor cells, CD8+ cells, and CD4+ cells were not significant predictive markers for outcome. Conclusion: Quantitative spatial profiling by multiplex immunofluorescence is feasible in FFPE glioblastoma tissue. More refined and extensive quantitative and spatial microenvironment analyses may allow for the development of biomarkers for immunotherapy in GBM.
Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection
Authors: Novo Irene , López-Cortegano Eugenio , Caballero Armando 
Published: March 2021

Abstract
Recent studies have shown the ubiquity of pleiotropy for variants affecting human complex traits. These studies also show that rare variants tend to be less pleiotropic than common ones, suggesting that purifying natural selection acts against highly pleiotropic variants of large effect. Here we investigate the mean frequency, effect size and recombination rate associated with pleiotropic variants, and focus particularly on whether highly pleiotropic variants are enriched in regions with putative strong background selection. We evaluate variants for 41 human traits using data from the NHGRI-EBI GWAS Catalog, as well as data from other three studies. Our results show that variants involving a higher degree of pleiotropy tend to be more common, have larger mean effect sizes, and contribute more to heritability than variants with a lower degree of pleiotropy. Using data from four different studies, we show that more pleiotropic variants are enriched in genome regions with stronger background selection than less pleiotropic variants. Thus, we conclude that even though highly pleiotropic variants found so far have larger average effect sizes and frequencies than less pleiotropic ones, they are likely to be subjected to stronger background selection.
How Epithelial Cells Reorient in Response to Cyclic Stretching
Authors: Lien Jui-Chien , Wang Yu-Li 
Published: March 2021

Abstract
Many types of adherent cells are known to reorient upon uniaxial cyclic stretching perpendicularly to the direction of stretching to facilitate such important events as wound healing, angiogenesis, and morphogenesis. While this phenomenon has been documented for decades, the underlying mechanism remains poorly understood. Using an on-stage stretching device that allowed programmable stretching with synchronized imaging, we found that the reorientation of NRK epithelial cells took place primarily during the relaxation phase when cells underwent rapid global retraction followed by extension transverse to the direction of stretching. Inhibition of myosin II caused cells to orient along the direction of stretching, whereas disassembly of microtubules enhanced transverse reorientation. Our results indicate distinct roles of stretching and relaxation in cell reorientation and implicate a role of myosin II-dependent contraction via a microtubule-modulated mechanism. The importance of relaxation phase also explains the difference between the responses to cyclic and static stretching.
Philosophical foundations of research, and the case of the epistemic well, in a least developed nation.
Authors: Chakravartty Avaniendra 
Published: March 2021

Abstract
Inspired by an ancient tale of kupamanduka (Well Frog) that never ventures out of the well and lives to think the well as the world and see nothing beyond it. This article conceptualises the ‘Epistemic Well’ and the native epistemic community that dwells in it remains within the confines of the epistemic well. Philosophical foundations are the core of each individual researcher and all research questions, hypothesis, methodologies, recommendations are shaped by it. Particular modes of governance instil particular modes of philosophies. Under neoliberalism the prevailing philosophical foundations have been identified as, detached, decontextualized, depoliticized, dehistoricized, dissocialized, deproblematized, reductionist/individualist, instrumentalization, separation, marketisation, positivist and objectivist. The combination of these attributes builds the epistemic well. The epistemic well of research is not absolute and is not meant to provide quantification data. The epistemic well is a reflexive tool that can be used to evaluate a research especially for a nation like Nepal. The research funds or the benefits that ensues a researcher are important criteria for research. When thinking of a research topic, the primary determining factor becomes the amount of fund available the gaze of a native researcher can overlook various conditions and processes. The epistemic community that is formed by these researchers maintain and sustain particular epistemes. The NCD’s were selected primarily to stick to a cohort but this does not limit the scope and purpose of the epistemic well.
Electrically Controllable Active Plasmonic Directional Coupler of Terahertz Signal based on a Periodical Dual Grating Gate Graphene Structure
Authors: Morozov Mikhail Yu. , Popov Vyacheslav V. , Fateev Denis V. 
Published: March 2021

Abstract
We propose a concept of an electrically controllable plasmonic directional coupler of terahertz signal based on a periodical structure with an active (with inversion of the population of free charge carriers) graphene with a dual grating gate and numerically calculate its characteristics. Proposed concept of plasmon excitation by using the grating gate offers highly effective coupling of incident electromagnetic wave to plasmons as compared with the excitation of plasmons by a single diffraction element. The coefficient which characterizes the efficiency of transformation of the electromagnetic wave into the propagating plasmon has been calculated. This transformation coefficient substantially exceeds the unity (exceeding 6 in value) due to amplification of plasmons in the studied structure by using pumped active graphene. We have shown that applying different dc voltages to different subgratings of the dual grating gate allows for exciting the surface plasmon in graphene, which can propagate along or opposite the direction of the structure periodicity, or can be a standing plasma wave for the same frequency of the incident terahertz wave. The coefficient of unidirectionality, which is the ratio of the plasmon power flux propagating along (opposite) the direction of the structure periodicity to the sum of the absolute values of plasmon power fluxes propagating in both directions, could reach up to 80 percent. Two different methods of the plasmon propagation direction switching are studied and possible application of the found effects are suggested.
­­Duloxetine for the prevention of oxaliplatin induced peripheral neuropathy: a randomized, placebo-controlled, double-blind clinical trial
Authors: Aghili Mahdi , Darzikolaee Nima Mousavi , Babaei Mohammad , Ghalehtaki Reza , Farhan Farshid , Razavi Seyede Zahra Emami , Rezaei Saeed , Esmati Ebrahim , Samiei Farhad , Azadvari Mohadese , Farazmand Borna , Amiri Ardavan 
Published: March 2021

Abstract
IntroductionPeripheral neuropathy is a dose-limiting adverse effect of oxaliplatin. The aim of this study was to evaluate the efficacy and safety of duloxetine in the prevention of oxaliplatin-induced peripheral neuropathy (OIPN).MethodCancer patients receiving oxaliplatin chemotherapy were randomized into two arms. Duloxetine 60 mg capsule was given in the first 14 days of each chemotherapy cycle to one arm and placebo was similarly given to another arm. We compared the two arms based on the incidence of neuropathy and the results of the nerve conduction study.ResultsThirty two patients were randomized to duloxetine and placebo arms. Most of the patients had rectal cancer (90.6%). Compared with the placebo arm, patients in the duloxetine arm had a lower percentage of chemotherapy cycles (mean) in which they reported distal paresthesia (84% vs. 51%, P = 0.01) and throat discomfort (69% vs. 37%, P = 0.01). There was no difference in the percentage of cycles in which patients reported cold-induced dysesthesia. Highest grade of neuropathy in each cycle was not significantly different between the two arms. Six weeks after the last cycle of chemotherapy, nerve conduction velocity was significantly higher in duloxetine arm compared to the placebo arm in the deep peroneal nerve and tibial nerve. Duloxetine was safe and well-tolerated.ConclusionIn spite of small sample size, results of this study suggests potential efficacy of duloxetine in the prevention of OIPN, as indicated by objective measures of neurotoxicity and some patient-reported symptoms.
C-STICH: Cerclage Suture Type for an Insufficient Cervix and its Effect on Health Outcomes. A Multicentre Randomised Controlled Trial.
Authors: Israfil-Bayli Fidan , Morton Victoria Ann Hodgetts , Hewitt Catherine A , Ewer Andrew K , Grey Jim , Norman Jane , Lees Christoph , Simpson Nigel A B , Shennan Andrew , Hughes Max , Daniels Jane , Brocklehurst Peter , Morris R.Katie , Middleton Lee , Toozs-Hobson Philip 
Published: March 2021

Abstract
Background: Preterm birth is associated with significant mortality and morbidity for mothers and babies. Women are identified as high risk for preterm birth based on either previous medical/pregnancy history or on ultrasound assessment of the cervix. Women identified as high risk can be offered a cervical cerclage (a purse string stitch) around the cervix (neck of the womb) to reduce the risk of preterm birth. In women who have a cervical cerclage the procedure can be performed using either a monofilament (single-stranded) or braided (woven) suture material. Both suture materials are routinely used for cervical cerclage and there is uncertainty as to which is superior. Methods: A multicentre, open, randomised controlled superiority trial of 2050 women presenting at obstetric units, deemed to be at risk of preterm birth and already scheduled to have a cervical cerclage as part of their standard care. Inclusion criteria include singleton pregnancies and an indication for cervical cerclage for either: a history of three or more previous mid trimester losses or premature births (≤ 28 weeks), insertion of cervical sutures in previous pregnancies, a history of mid trimester loss or premature birth with a (current) shortened (≤ 25 mm) cervix, or women whom clinicians deem to be at risk of preterm birth either by history or the results of an ultrasound scan. Exclusion criteria include women; who have taken part in C-STICH previously, aged less than 18 years old at the time of presentation, requiring a rescue cerclage, who are unwilling or unable to give informed consent and in whom a cerclage will be placed by any route other than vaginally (e.g. via an abdominal route). Following informed consent, women are randomised on a 1:1 basis to either monofilament or braided suture, by minimisation. The primary outcome is pregnancy loss (miscarriage and perinatal mortality, including any stillbirth or neonatal death in the first week of life) and secondary outcomes include the core outcome set for preterm birth trials.Discussion: Optimising established interventions to prevent preterm birth is important in reducing perinatal mortality rates.Trial registration: ISRCTN 15373349 registered before recruitment 03/12/2014 prior to first recruit.
CASP9 As a Prognostic Biomarker and Promising Drug Target Plays a Pivotal Role in Inflammatory Breast Cancer
Authors: Zhang Mingdi , Wu Kejin , Wang Maoli , Bai Fang , Chen Hongliang 
Published: March 2021

Abstract
Background : Inflammatory breast cancer (IBC) is one of the most rare and aggressive subtype of primary breast cancer (BC). Our study aimed to explore hub genes related to the pathogenesis of IBC, which could be considered as novel molecular biomarkers for IBC diagnosis and prognosis. Material and Methods: Two datasets from gene expression omnibus database (GEO) were selected. Enrichment analysis and protein-protein interaction (PPI) network for the DEGs were performed. We analyzed the prognostic values of hub genes in the Kaplan–Meier Plotter. Connectivity Map (CMap) and Comparative Toxicogenomics Database (CTD) was used to find candidate small molecules capable to reverse the gene status of IBC. Results : 157 DEGs were selected in total. We constructed the PPI network with 154 nodes interconnected by 128 interactions. KEGG pathway analysis indicated that the DEGs were enriched in apoptosis, pathways in cancer and insulin signaling pathway. PTEN, PSMF1, PSMC6, AURKB, FZR1, CASP9, CASP6, CASP8, BAD, AKR7A2, ZNF24, SSX2IP, SIGLEC1, MS4A4A and VSIG4 were selected as hub genes based on the high degree of connectivity. Six hub genes (PSMC6, AURKB, CASP9, BAD, ZNF24 and SSX2IP) that were significantly associated with the prognosis of breast cancer. The expression of CASP9 protein was associated with prognosis and immune cells infiltration of breast cance. CASP9- naringenin (NGE) is expected to be the most promising candidate gene-compound interaction for the treatment of IBC. Conclusion : Taken together, CASP9 can be used as a prognostic biomarker and a novel therapeutic target in IBC.
Essential norms and Schatten(-Herz) classes of integration operators from Bergman spaces to Hardy spaces
Authors: Chen Jiale , Pau Jordi , Wang Maofa 
Published: March 2021

Abstract
In this paper, we completely characterize the compactness of the Volterra type integration operators Jb acting from weighted Bergman spaces Apa to Hardy spaces Hq for all 0 < p; q < 1. Furthermore, we give some estimates for the essential norms of Jb : Apa -> Hq in the case 0 < p < q < 1. We finally describe the membership in the Schatten(-Herz) class of the Volterra type integration operators.
Solving the mystery of the walk-off soliton
Authors: Zitelli Mario , Mangini Fabio , Ferraro Mario , Sidelnikov Oleg , Wabnitz Stefan 
Published: March 2021

Abstract
Pioneering works on multimode fiber transmission [1,2], dated 40 years ago, predicted the existence of multimode solitons, providing conditions for the temporal trapping of the input optical modes to form a spatiotemporal soliton [3-5]. Only recently [6-8], multimode solitons were experimentally investigated in graded-index multimode fibers (GRIN), unveiling the complexity of a new, uncharted field. In our work, we experimentally and numerically investigated the propagation of ultrashort pulses over long distances of GRIN fiber. We discovered a new class of spatiotemporal solitons with surprising properties: basically single-mode, they cannot be described by the variational theory; their pulsewidth and energy are independent of the input pulse duration, and appear to depend only on the fiber dispersive parameters and, therefore, the wavelength. The new solitons are promising for the delivery of high-energy laser beams, for high-power spatiotemporal mode-locked multimode fiber lasers, and for high-bit rate
multimode fiber networks.
Long-Term Monitoring of SARS-COV-2 RNA in Wastewater in Brazil: A More Responsive and Economical Approach
Authors: Claro Ieda Carolina , Cabral Aline , Augusto Matheus , Duran Adriana , Graciosa Melissa Cristina , Fonseca Fernando Luiz , Speranca Marcia Aparecida , Bueno Rodrigo 
Published: March 2021

Abstract
SARS-CoV-2, the novel Coronavirus, was first detected in Wuhan, China, in December 2019, and has since spread rapidly, causing millions of deaths worldwide. As in most countries of the world, in Brazil, the consequences of the COVID-19 pandemic have been catastrophic. The increasing of deaths and the decrease of available beds in the hospitals, especially in 2021, have disturbed the health authorities. Several studies have reported the fecal shedding of SARS-CoV-2 RNA titers from infected symptomatic and asymptomatic individuals. Therefore, the quantification of SARS-CoV-2 in wastewater can be used to track the virus spread in a population via Wastewater-based Epidemiology (WBE). In this study, samples of untreated wastewater were collected weekly between June 9th, 2020 and March 17th, 2021 (41 weeks) at five sampling sites in the ABC Region, São Paulo, Brazil. This long-term monitoring was performed to evaluate the SARS-CoV-2 occurrence in the sewerage system. SARS-CoV-2 RNA titers were detected throughout the period. The viral RNA concentration ranged from 2.7 to 7.1 log10 genome copies.L− 1, with peaks in the last weeks of monitoring. Furthermore, we observed a positive correlation between the viral load in wastewater samples and the epidemiological/clinical data, with the former preceding the latter by approximately two weeks. The COVID-19 prevalence for each sampling site was estimated using the viral load observed in wastewater and other parameters, via Monte-Carlo simulation. The mean predicted prevalence ranged 0.05 to 0.38%, slightly higher than reported (0.016 ± 0.005%) in the ABC Region for the same period. These results highlight the viability of the WBE approach for COVID-19 infection monitoring in the largest urban agglomeration in South America. Environmental surveillance can be especially useful for health agencies and public decision-makers in predicting SARS-CoV-2 outbreaks, as well as in local tracing of infection clusters.
Controlling the pandemic during the SARS-CoV-2 vaccination rollout: a modeling study
Authors: Viana João , Dorp Christiaan van , Nunes Ana , Gomes Manuel , Boven Michiel van , Kretzschmar Mirjam , Veldhoen Marc , Rozhnova Ganna 
Published: March 2021

Abstract
There is a consensus that mass vaccination against SARS-CoV-2 will ultimately end the COVID-19 pandemic. However, it is not clear when and which control measures can be relaxed during the rollout of vaccination programmes. We investigate relaxation scenarios using an age-structured transmission model that has been fitted to age-specific seroprevalence data, hospital admissions, and projected vaccination coverage for Portugal. Our analyses suggest that the pressing need to restart socioeconomic activities could lead to new pandemic waves, and that substantial control efforts prove necessary throughout 2021. Using knowledge on control measures introduced in 2020, we anticipate that relaxing measures completely or to the extent as in autumn 2020 could launch a wave starting in April 2021. Additional waves could be prevented altogether if measures are relaxed as in summer 2020 or in a step-wise manner throughout 2021. We discuss at which point control of COVID-19 would be achieved for each scenario.