bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cholecystokinin Suppresses β-Cell Apoptosis, Including in Human Islets in a Transplant Model
Authors: Kim Hung Tae , de Souza Arnaldo H. , Umhoefer Heidi , Han JeeYoung , Anzia Lucille , Sacotte Steven J. , Williams Rashaun A. , Blumer Joseph T. , Bartosiak Jacob T. , Fontaine Danielle A. , Baan Mieke , Kibbe Carly R. , Davis Dawn Belt 
Published: March 2021

AbstractLoss of functional pancreatic β-cell mass and increased β-cell apoptosis are fundamental to the pathophysiology of both type 1 and type 2 diabetes. Pancreatic islet transplantation has the potential to cure type 1 diabetes but is often ineffective due to the death of the islet graft within the first few years after transplant. Therapeutic strategies to directly target pancreatic β-cell survival are needed to prevent and treat diabetes and to improve islet transplant outcomes. Reducing β-cell apoptosis is also a therapeutic strategy for type 2 diabetes. Cholecystokinin (CCK) is a peptide hormone typically produced in the gut after food intake, with positive effects on obesity and glucose metabolism in mouse models and human subjects. We have previously shown that pancreatic islets also produce CCK. The production of CCK within the islet promotes β-cell survival in rodent models of diabetes and aging. Now, we demonstrate a direct effect of CCK to reduce cytokine-mediated apoptosis in a β-cell line and in isolated mouse islets in a receptor-dependent manner. However, whether CCK can protect human β-cells was previously unknown. Here, we report that CCK can also reduce cytokine-mediated apoptosis in isolated human islets and CCK treatmentin vivodecreases β-cell apoptosis in human islets transplanted into the kidney capsule of diabetic NOD/SCID mice. Collectively, these data identify CCK as a novel therapy that can directly promote β-cell survival in human islets and has therapeutic potential to preserve β-cell mass in diabetes and as an adjunct therapy after transplant.One Sentence SummaryCholecystokinin ameliorates pancreatic β-cell death under models of stress and after transplant of human islets.
Process modeling for smart factories: using science mapping to understand the strategic themes, main challenges and future trends
Authors: Sott Michele Kremer , Furstenau Leonardo B. , Kipper Liane Mahlmann , Reckziegel Rodrigues Yan Pablo , López-Robles José Ricardo , Giraldo Fáber D. , Cobo Manuel J. 
Published: March 2021

PurposeThe purpose of this paper is to identify the relationships between process modeling and Industry 4.0, the strategic themes and the most used process modeling language in smart factories. The study also presents the growth of the field of study worldwide, the perspectives, main challenges, trends and suggestions for future works.Design/methodology/approachTo do this, a science mapping was performed using the software SciMAT, supported by VOS viewer.FindingsThe results show that the Business Process Model and Notation (BPMN), Unified Modelling Language (UML) and Petri Net are the most relevant languages to smart manufacturing. The authors also highlighted the need to develop new languages or extensions capable of representing the dynamism, interoperability and multiple technologies of smart factories.Originality/valueIt was possible to identify the most used process modeling languages in smart environments and understand how these languages assist control and manage smart processes. Besides, the authors highlighted challenges, new perspectives and the need for future works in the field.
Exploring an adaptability approach: how creative return processors impact firm performance
Authors: Espinosa Jennifer A. , Stock James , Ortinau David J. , Monahan Lisa 
Published: March 2021

PurposeThe authors explore complex adaptive systems (CAS) theory as an updated theoretical perspective for managing product returns that better matches the chaotic nature of recent consumer behaviors. CAS theory highlights the importance of agents who create and self-organize to help systems adapt in unpredictable environments.Design/methodology/approachThis research utilizes data collected from return managers in an online survey and applies regression analyses to estimate the influence of the focal variables.FindingsEmpirical evidence of the firm flexibility–firm adaptability link is established, and return processor creativity positively relates to this link. The firm flexibility–firm adaptability link fully mediates the relationship between return processor creativity and returns management performance and partially mediates the relationship between return processor creativity and relationship quality. Nonmediated effects were observed for turnover and revenue size.Practical implicationsManagers of returns who embrace an adaptability approach become facilitators of returns by supporting processor creativity. Enhancing the autonomy of processors in their day-to-day work increases the knowledge-creation capabilities of the firm, which helps the firm move forward and adapt in an uncertain environment.Originality/valueThis research presents empirical evidence of the underlying mechanisms of CAS theory in the product returns context by studying processor agents and argues that CAS theory better fits the current dynamics of the product returns environment. Further, this paper extends work by Espinosaet al.(2019) and Nilsson (2019) by studying how a specific human characteristic – creativity – impacts product returns management.
The ISO 30401 knowledge management systems standard – a new framework for value creation and research?
Authors: Pawlowsky Peter , Pflugfelder Nina S. , Wagner Maik H. 
Published: March 2021

PurposeThe article reviews major developments in the literature on knowledge management and intellectual capital management. It provides a description and visualization of the structure and content of the ISO 30401 and critically benchmarks its clauses against comprehensive taxonomies from the literature.Design/methodology/approach2018 saw the release of the ISO 30401 Knowledge Management Systems Standard, a type A regulation which may serve as a basis for certification. It builds on and integrates a broad and conceptually diverse literature on knowledge resources (e.g. intellectual capital theory, knowledge management theory). This article aims to show how the management systems standard relates to the literature it is built on and provides directions for its further operationalization by certification bodies and implementation by managers.FindingsThe ISO 30401 successfully integrates a diverse body of literature in a broadly applicable cross-industry standard. To operationalize and implement it, certification bodies and managers should build on empirical evidence of “what works,” taking into account market characteristics as well as organizational properties. Further research should support the implementation of the standard by developing KM measurement frameworks and context-specific studies of KM tools and methods.Originality/valueThis article is the first to systematically compare the ISO 30401 to the underlying theory. This paper uncovers avenues for research and makes suggestions for the standard's operationalization in practice.
Association of body fat distribution and metabolic syndrome with the occurrence of colorectal adenoma: A case‐control study
Authors: Liu Zhong Hui , Zhang Gui Xi , Zhang Hao , Jiang Li , Deng Yang , Chan Fion Siu Yin , Fan Joe King Man 
Published: March 2021

ObjectiveVisceral fat is thought to play different roles in the carcinogenesis of the colon with peripheral fat. Our aim was to evaluate the association of body fat distribution measured by bioelectrical impedance analysis (BIA) with the incidence of colorectal adenoma (CRA).MethodsA total of 410 asymptomatic participants who underwent a screening colonoscopy from July 2017 to December 2019 in our center were recruited, including 230 with adenomas and 180 without detected adenomas. The participants’ body fat was measured by BIA, including their body fat mass (BFM), body fat percentage (BFP), and waist‐to‐hip ratio. Parameters of metabolic syndrome (MetS), including waist circumference, blood pressure, fasting blood glucose (FBG), blood level of triglyceride, cholesterol, and high‐density lipoprotein were measured as well.ResultsAccording to univariate analysis, age, male sex, body mass index, waist circumference, BFM, waist‐to‐hip ratio, blood pressure, and FBG were higher in the adenoma group than in the adenoma‐free group (P < 0.05). On multivariate logistical analysis (adjusted for age, sex, smoking, drinking, and family history of CRC), a high waist‐to‐hip ratio was associated with a high incidence of CRA (odds ratio [OR] 1.84, 95% confidence interval [CI] 1.09‐3.09, P = 0.02). Only a large waist circumference in components of MetS was independently associated with the incidence of CRA (OR 1.90, 95% CI 1.17‐3.08, P = 0.01) in the multivariate analysis.ConclusionBody fat distribution is associated with CRA, central obesity is a core risk factor for CRA in MetS. Chinese Clinical Trial Registration number: ChiCTR‐RRC‐17010862.
Methyl‐CpG binding protein 2 dysfunction provides stress vulnerability with sex‐ and zygosity‐dependent outcomes
Authors: Cosentino Livia , Bellia Fabio , Pavoncello Nicole , Vigli Daniele , D'Addario Claudio , De Filippis Bianca 
Published: March 2021

AbstractStress vulnerability is a critical factor for the development of trauma‐related disorders; however, its biological underpinnings are not clear. We demonstrated that dysfunctions in the X‐linked epigenetic factor methyl‐CpG binding protein 2 (MeCP2) provide trauma vulnerability in male mice. Given the prominent role of sex in stress outcomes, we explored the effects of MeCP2 hypofunctionality in females. Female mice carrying truncated MeCP2 (heterozygous and homozygous) and wild type controls (wt) were tested for fear memory. Stress‐induced corticosterone release and brain expression of hypothalamic‐pituitary‐adrenal (HPA) axis regulatory genes were also evaluated in wt and mutant mice of both sexes. Although heterozygous females displayed a normal stress‐related behavioural profile, homozygous mice showed enhanced memory recall for the threatening context compared to wt, thus recapitulating the phenotype previously evidenced in hemizygous males. Interestingly, MeCP2 truncation abolished the sex differences in stress‐induced corticosterone release, which was found increased in mutant males, whereas blunted in mutant females in a zygosity‐independent manner. Although heterozygous mice did not differ from controls, homozygous females and hemizygous males showed increased hypotalamic Crh and Avp mRNAs and a differentially altered expression of Fkbp5 in cortical areas. Present results demonstrate that in female mice carrying truncated MeCP2, altered stress responsivity is driven by homozygosity, whereas heterozygosity does not lead to maladaptive stress outcomes. MeCP2 dysfunctions thus provide stress vulnerability in mice with sex‐ and zygosity‐dependent outcomes.
Misdiagnosis and diagnostic pitfalls of chronic inflammatory demyelinating polyradiculoneuropathy
Authors: Broers Merel C. , Bunschoten Carina , Drenthen Judith , Beck Tiago A. O. , Brusse Esther , Lingsma Hester F. , Allen Jeffrey A. , Lewis Richard A. , van Doorn Pieter A. , Jacobs Bart C. 
Published: March 2021

AbstractBackground and purposeThe aim of this study was to determine the frequency of over‐ and underdiagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and to identify related diagnostic pitfalls.MethodsWe conducted a retrospective study in Dutch patients referred to the Erasmus University Medical Centre Rotterdam between 2011 and 2017 with either a diagnosis of CIDP or another diagnosis that was revised to CIDP. We used the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) 2010 diagnostic criteria for CIDP to classify patients into three groups: overdiagnosis, underdiagnosis, or confirmed diagnosis of CIDP. Clinical and laboratory features and treatment history were compared between groups.ResultsA referral diagnosis of CIDP was revised in 32% of patients (31/96; overdiagnosis). Of 81 patients diagnosed with CIDP, 16 (20%) were referred with another diagnosis (underdiagnosis). In the overdiagnosed patients, 20% of muscle weakness was asymmetric, 48% lacked proximal muscle weakness, 29% only had distal muscle weakness, 65% did not fulfil the electrodiagnostic criteria for CIDP, 74% had an elevated cerebrospinal fluid (CSF) protein level, and 97% had another type of neuropathy. In the underdiagnosed patients, all had proximal muscle weakness, 50% had a clinically atypical CIDP, all fulfilled the electrodiagnostic criteria for CIDP, and 25% had an increased CSF protein level.ConclusionOver‐ and underdiagnosis of CIDP is common. Diagnostic pitfalls include lack of attention to proximal muscle weakness as a diagnostic hallmark of CIDP, insufficient recognition of clinical atypical phenotypes, overreliance on CSF protein levels, misinterpretation of nerve conduction studies and poor adherence to electrodiagnostic criteria, and failure to exclude other causes of polyneuropathy.
Tofacitinib treatment for refractory autoimmune encephalitis
Authors: Jang Yoonhyuk , Lee Woo‐Jin , Lee Han Sang , Chu Kon , Lee Sang Kun , Lee Soon‐Tae 
Published: March 2021

AbstractTo treat intractable cases of autoimmune encephalitis, the need for novel immunotherapy that penetrates the blood‐brain barrier (BBB) is increasing. Tofacitinib is a Janus kinase (JAK) inhibitor used to treat refractory immune‐mediated diseases that effectively penetrates the BBB. Accordingly, tofacitinib could be a new option for patients with refractory autoimmune encephalitis. Patients treated with tofacitinib were selected from Seoul National University Hospital cohort for autoimmune encephalitis from April 2019 until July 2020. We retrospectively analyzed the efficacy of tofacitinib in patients with autoimmune encephalitis who showed insufficient responses to multimodal conventional immunotherapies. Tofacitinib was administered orally at a dose of 5 mg twice daily. A total of eight patients were treated with tofacitinib; two had good responses (clinical global impression‐improvement score [CGI‐I] = 1 or 2), three had partial responses (CGI‐I = 3), and three showed no significant improvements (CGI‐I = 4) in response to tofacitinib. The two good responders showed the improvement of chronic autoimmune meningoencephalitis and the cessation of the new‐onset refractory status epilepticus in anti‐myelin oligodendrocyte glycoprotein (MOG)–associated disorder, which was previously intractable to anesthetics and the other immunotherapies. No patients had serious side effects. Our findings suggest the potential of tofacitinib as a therapeutic option for central nervous system autoimmune diseases.
Drug utilisation pattern over 3 years in the real‐world treatment of type II diabetes
Authors: Romagnoli Alessia , Santoleri Fiorenzo , Costantini Alberto 
Published: March 2021

AbstractIntroductionNon‐adherence to therapy is very common in patients with type II diabetes, leading to an increase in morbidity and mortality. The development of new oral therapies following metformin has increased the possibilities of treatment but little has been done in terms of improving medication adherence. The goal of the following study is to evaluate adherence and persistence over a period of 3 years in real‐world diabetic patients and describe the comorbidities found in the group of patients studied.Material and MethodologyA non‐interventional pharmacological observational study was conducted by examining all therapies from 2011 to 2019 at a local health centre in Pescara (ASL). The medication adherence and persistence over a 3‐year period were calculated using the pharmacy‐refill method. The identification of the comorbidities was carried out in accordance with the Anatomical Therapeutic Chemical (ATC) Classification system at the fourth level.ResultsA total of 19 600 patients undergoing treatment for type II diabetes from January 2011 to December 2019 were analysed. The absolute adherence value at 3 years was 0.68 ± 0.23. The 3‐year persistence curves showed a statistically significant difference (P < .0001). The ATCs with highest figures in the entire study group were: A02BC, B01AC and C10AA with 14 220, 13 934 and 10 858 patients, respectively.ConclusionsAdherence to therapy was suboptimal, while persistence curves showed a statistically significant difference, with patients treated with metformin showing better results. Comorbidities analysed showed a greater relevance of heart disease.
Self‐gift giving and satisfaction with life: A behavioural tendency perspective
Authors: d’Astous Alain , Mouakhar‐Klouz Dania 
Published: March 2021

AbstractThis research considers self‐gift giving as an individual disposition—that is, the extent to which a consumer is inclined to buy herself or himself gifts—and examines some determinants and consequences of this general tendency. A conceptual model was developed where self‐gift giving propensity is hypothesized to follow from gift‐receiving experiences during childhood and lead to long‐term consequences relative to materialism and satisfaction with life (SWL). In addition, gift‐receiving experiences during childhood are also presumed to give rise to a greater level of consumer sociability and, ultimately, a better satisfaction with life. The model was tested using data collected by means of a survey among a sample of 186 adult consumers. The results show that self‐gift giving propensity may have positive or negative effects on consumer SWL, depending on the particular psychological mechanisms that intervene. As a behavioural response to various events in one's life, self‐gifting episodes lead in a cumulative fashion to a better satisfaction with life. However, self‐gift giving propensity also lead to a higher level of materialism and, as a consequence, a degradation of life satisfaction. This study has adopted a life‐span perspective on this particular behaviour and has contributed to identify different psychological processes that explain how self‐gift giving tendencies come about as well as the long‐term consequences that they engender. This study has enriched our knowledge of the self‐gift phenomenon by placing this common consumption behavior in a broader perspective than the motivational, and episodic, approach that has characterized most research in this domain until now.
The Indo‐European flyway: Opportunities and constraints reflected by Common Rosefinches breeding across Europe
Authors: Lisovski Simeon , Neumann Roland , Albrecht Tomas , Munclinger Pavel , Ahola Markus P. , Bauer Silke , Cepak Jaroslav , Fransson Thord , Jakobsson Sven , Jaakkonen Tuomo , Klvana Petr , Kullberg Cecilia , Laaksonen Toni , Metzger Benjamin , Piha Markus , Shurulinkov Peter , Stach Robert , Ström Kåre , Velmala William , Briedis Martins 
Published: March 2021

AbstractAimThe configuration of the earth's landmasses influences global weather systems and spatiotemporal resource availability, thereby shaping biogeographical patterns and migratory routes of animals. Here, we aim to identify potential migratory barriers and corridors, as well as general migration strategies within the understudied Indo‐European flyway.LocationEurope, Central Asia.Major taxon studiedCommon rosefinches.MethodsWe used a combination of theoretical optimization modelling and empirical tracking of Common Rosefinches (Carpodacus erythrinus) breeding across a large latitudinal gradient in Europe. First, we identified optimal migration routes driven by wind and resource availability along the Indo‐European flyway. Second, we tracked rosefinches from five breeding populations using light‐level geolocators. Finally, we compared to what extent empirical tracks overlapped with the modelled optimal routes.ResultsIn autumn, theoretical wind driven migration routes formed a broad‐front corridor connecting Europe and the Indian Subcontinent while the theoretical resource driven routes formed a distinct north‐south divide. The latter pattern also reflected the rosefinch tracks with all but the most southerly breeding birds making a northern detour towards non‐breeding sites in Pakistan and India. In spring, the resource availability model predicted a similar migratory divide, however, the southern route seemed relatively more favourable and closely matched with the optimal wind driven migration routes. Spring tracking data showed larger overlap with the modelled wind driven migration routes compared to the resource driven routes.Main conclusionsOptimal wind and resource driven migration routes along the Indo‐European flyway are seasonally specific and to a large extend do not overlap with one another. Under these conditions, migratory birds adopt seasonally distinct migration strategies following energy minimization strategy in autumn, driven by resource availability, and time minimizing strategy in spring, driven by wind conditions. Our optimal migration models can be applied worldwide and used to validate against empirical data to explain large‐scale biogeographic pattern of migratory animals.
Referral criteria to specialist palliative care for patients with dementia: A systematic review
Authors: Mo Li , Geng Yimin , Chang Yuchieh Kathryn , Philip Jennifer , Collins Anna , Hui David 
Published: March 2021

AbstractBackgroundPatients with dementia often have significant symptom burden and a progressive course of functional deterioration. Specialist palliative care referral may be helpful, but it is unclear who and when patients should be referred. We conducted a systematic review of the literature to examine referral criteria for palliative care among patients with dementia.MethodsWe searched Ovid MEDLINE, Ovid Embase, Ovid PsycInfo, Cochrane Library, PubMed, and CINAHL databases for articles from inception to December 3, 2019, related to specialist palliative care referral for dementia. Two investigators independently reviewed the citations for inclusion, extracted the referral criteria, and categorized them thematically.ResultsOf the 1788 citations, 59 articles were included in the final sample. We identified 13 categories of referral criteria, including 6 disease‐based and 7 needs‐based criteria. The most commonly discussed criterion was “dementia stage” (n = 43, 73%), followed by “new diagnosis of dementia” (n = 17, 29%), “medical complications of dementia” (n = 12, 20%), “prognosis” (n = 11, 19%), and “physical symptoms” (n = 11, 19%). Under dementia stage, 37/44 (84%) articles recommended a palliative care referral for advanced dementia. Pneumonia (n = 6, 10%), fall/fracture (n = 4, 7%), and decubitus ulcers (n = 4, 7%) were most commonly discussed complications to trigger a referral. Under prognosis, the time frame for referral varied from <2 years of life expectancy to <6 months. 3 (5%) of articles recommended “surprise question” as a potential trigger.ConclusionsThis systematic review highlighted the lack of consensus regarding referral criteria for palliative care in patients with dementia and the need to identify timely triggers to standardize referral.