bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical Assesment of the Infuence of Use Bottom Air Decking ½ Meter on the Powder Factor Value in Lowwall Area C1 at PT Bukit Makmur Mandiri Utama Site Binungan, Kalimantan Timur
Authors: Vidiya Ricce Ivonda , Anggara Rochsyid , Asnawi Sato 
Published: February 2025

Abstract
The research was conducted at PT Bukit Makmur Mandiri Utama Site Binungan, East Kalimantan. The research aims to reduce the powder factor value in blasting in the Lowwall C1 (include seam F5 Barat, F5 Expose, F5 Mine Out and F4) area which refers to the company’s target standard of 0.183 kg/m3, without changing the blasting results in the form of fragmentation value, digging time and material recovery. The powder factor is the ratio of powder filling to the volume of blasting results. Efforts to reduce the powder factor value can be made by using the ½ meter air deck experiment, this is done because the geometry cannot be changed and is optimal. Reducing the powder factor value using ½ meter air deck by paying attention to changes in the loading sheet value. After making the loading sheet value for ½ meter, there is a change in the amount of powder filling by 9-13 kg for each hole; the depth of the blast hole influences this reduction, After the trial was conducted, the powder factor value decreased by 3%, while the fragmentation value followed the target set by the company (below 50 cm), the digging time value produced was in accordance with the company (below 12 seconds), and the recovery value reached the target of 95%. So it can be concluded that the experiment using ½ meter air deck is successful and can be done for Lowwall C1 area.
Safety Assessment for Geotourism in Ciletuh-Palabuhanratu UNESCO Global Geopark, West Java
Authors: Herlinawati  , Setiawan Iwan F , Rohaendi Nendi , Wahyudi  
Published: February 2025

Abstract
Geopark areas offer a unique opportunity for geotourism, allowing visitors to experience geological wonders while immersing themselves in local culture and biodiversity. However, ensuring the safety of both visitors and the environment is critical for sustainable development and visitor satisfaction. The Ciletuh-Palabuhanratu Geopark, part of the UNESCO Global Geopark network, is situated in the Sukabumi Regency of West Java and is a prime example of such an area. The park offers diverse landscapes shaped by millions of years of geological processes, including cascading waterfalls, stunning cliffs, pristine beaches, lush forests, and rugged coastal areas. The aim of the research is to identify potential hazards in the tourism industry in Ciletuh-Palabuhanratu UNESCO Global Geopark and calculate associated risks by considering factors such as the likelihood and severity of these hazards on visitors, infrastructure, and the environment. The potential hazards were identified, analysed, and assessed in each geosite. The data sources used were primary and secondary ones taken from observation, open interviews, and literature studies. The results show that rockfalls and slippery rock are the highest physical hazards, posing a high level of risk. Meanwhile, landslides, snakes, bees, and poisonous plants are classified as low risk. Therefore, the safety assessment results of Ciletuh-Palabuhanratu UNESCO Global Geopark can serve as a reference for future development to ensure the park remains sustainable. By identifying and mitigating potential hazards, the park can continue to provide safe travel and enjoyable activities for visitors while protecting the community and environment.
Rheology of compressible and density-variable Newtonian flows: non-Stokes hypothesis and ‘volume diffusion’
Authors: Dadzie S Kokou 
Published: February 2025

Abstract
Stokes’ hypothesis allows for the frequent neglect of the bulk viscosity term related to fluid dilation effects on the viscous stress tensor in Newtonian flows. Configurations in which this hypothesis is not valid widely exist, but they are not always well distinguished. Meanwhile, it was pointed out earlier that the original Navier–Stokes equations may be incomplete, leading to the development of volume diffusion hydrodynamics. This article recalls the form of the Navier–Stokes equations when fluid dilation (or actual fluid density variation) is properly accounted for in the derivation process of continuum flow equations. A thermodynamic framework to construct constitutive equations is proposed. The results, which are deemed to be the exact and complete form of the Navier–Stokes equations, correspond to the volume diffusion continuum hydrodynamic model. Explicit expressions and meanings are derived for the local volume production rate, specifically the local fluid concentration production, which differ from the conventional definitions. This complete form of the Navier–Stokes equations represents natural Burnett regime hydrodynamic equations, as they satisfy all fundamental mechanical principles and exhibit non-negative entropy production. These continuum flow models may be more appropriate to adopt when local gradients in thermodynamic variables, such as density or temperature, impact the dynamics of the flows.
FloodGenome: interpretable machine learning for decoding features shaping property flood risk predisposition in cities
Authors: Liu Chenyue , Mostafavi Ali 
Published: February 2025

Abstract
The study introduces FloodGenome, an interpretable machine learning model, to assess flood risk disposition in urban areas by analyzing hydrological, topographic, and built-environment features and their interactions. Utilizing data from the U.S. National Flood Insurance Program (2003-2023) across four metropolitan areas, it employs k-means clustering and a random forest model to classify and predict property flood risk levels. The model's effectiveness is proven across different metropolitan areas, highlighting the importance of factors like vapor pressure, elevation, and impervious surfaces in determining flood risk. FloodGenome's analysis aids in evaluating future urban development impacts on flood risk and refining property flood risk assessments at a detailed level. This tool offers critical insights for flood risk management, supporting the development of urban design strategies to mitigate flood risks.
An integrated hybrid 3D bioprinting of heterogeneous and zone-specific construct resembling structural and biofunctional properties of osteochondral tissue
Authors: Wang Yaxin , Hou Yanhao , Vyas Cian , Huang Boyang , Bartolo Paulo J.D.S. 
Published: February 2025

Abstract
Extrusion-based 3D printing is extensively used to fabricate osteochondral (OC) constructs. However, significant challenges remain, particularly engineering constructs that can replicate the heterogeneity and structural organization of OC tissue and maintain a chondrogenic phenotype. Herein, this study introduces an integrated hybrid 3D bioprinting strategy, incorporating soft hydrogel bioinks and a bioceramic thermoplastic composite polymer, allowing the fabrication of a zone-specific construct analogous to OC tissue. The results show that the hybrid triphasic 3D bioprinted construct mimicking the full-thickness OC tissue displays a distinct layered structure with high precision and improved mechanical properties. The calcified layer fabricated by co-printing gelatin methacryloyl (GelMA) and polycaprolactone/tricalcium phosphate (PCL/TCP) enables the formation of a transition layer and provides strong bonding between the engineered PCL/TCP subchondral bone and the methacrylated methylcellulose (MCMA)/GelMA cartilage layer. The encapsulated human adipose-derived stem cells (hADSCs) are found to be spatiotemporally released from the calcified cartilage layer and directionally attach to the subchondral bone layer of the construct. The MCMA/GelMA bioinks exhibit a stiffness and stress relaxation profile suitable for cartilage applications. Human chondrocytes (HCs) show enhanced cell viability and proliferation. Moreover, the HCs encapsulated within the MCMA/GelMA bioinks maintain their chondrogenic phenotype with high expression of collagen type II (Col2) and SOX9. At the liquid-matrix interface, they experience a loss of chondrogenic phenotype and potential chondrogenic-to-osteogenic trans-differentiation with the expression of the osteogenic marker collagen type I (Col1). This study provides a deep understanding and insightful view of chondrogenic behaviours responding to the microenvironment via extensive in-vitro studies and shed light on a promising approach for the future OC tissue regeneration.
Dual-responsive ratiometric luminescent assay for visual recognition of tetracyclines based on in situ encapsulation of Eu(III) and carbon dots into metal-organic frameworks
Authors: Yi Kuiyu , Zhao Qifeng , Kang Xiaoqi 
Published: February 2025

Abstract
An efficient method of in situ self-assembly was utilized to encapsulate Eu3+ and carbon dots (CDs) within ZIF-8, creating a Eu3+/CDs@ZIF-8 dual-emissive ratiometric luminescent assay specifically designed for the recognition of tetracyclines (TCs). As the concentration of TCs rises, blue luminescence from CDs diminishes while red luminescence from Eu3+ intensifies. This mechanism, balancing 2 emissions, allows high-sensitivity detection of TCs in water and milk. TCs quench blue emission via inner filter effect and coordinate with Eu3+ to enhance red emission, causing a visible color shift. Consequently, the luminescence color of Eu3+/CDs@ZIF-8 can be visually observed to shift from blue to red. Furthermore, the developed luminescent test strip offers a portable and convenient solution for TCs detection, making it suitable for on-site analysis. The dual-emission self-calibration detection platform introduces a novel approach for the identification of TCs in food samples, providing a robust and reliable method for monitoring and ensuring environmental and food safety.
Caffeic acid O-methyltransferase-dependent flavonoid defenses promote sorghum resistance to fall armyworm infestation
Authors: Kundu Pritha , Shinde Sanket , Grover Sajjan , Sattler Scott E , Louis Joe 
Published: February 2025

Abstract
Sorghum (Sorghum bicolor), one of the world’s most important monocot crops, suffers severe yield losses due to attack by a polyphagous insect pest, fall armyworm (FAW; Spodoptera frugiperda). Here, we show that the Brown midrib 12 (Bmr12) gene, which encodes the caffeic acid O-methyltransferase (COMT) enzyme, promotes sorghum defense against FAW. Loss of Bmr12 function resulted in increased susceptibility, but enhanced resistance to FAW was observed in Bmr12-overexpression (OE) plants compared with wild-type (RTx430) plants. Although COMT is associated with modulating lignin levels, FAW infestation resulted in comparable lignin levels between bmr12 and Bmr12-OE sorghum plants. On the contrary, evidence presented here indicates that FAW feeding induced the accumulation of flavonoids, which was previously shown to have a negative impact on FAW growth and survival in Bmr12-OE plants compared with bmr12 and RTx430 plants. Furthermore, a combination of phytohormone profiling and transcriptomic analysis uncovered that COMT-mediated resistance to FAW depends on jasmonic acid (JA) and oxidative stress-associated pathways. Exogenous application of FAW oral secretions stimulated flavonoid accumulation in Bmr12-OE plants compared with bmr12 and RTx430 plants, indicating that COMT has an essential function in perceiving FAW oral cues. Taken together, the critical role of COMT in sorghum defense against FAW hinges upon the interplay between JA and its derivatives and hydrogen peroxide, which potentially helps to mount a robust flavonoid-based host defense upon caterpillar attack.
The fermentation broth of Streptomyces noursei strain S86 as a potential biocontrol product for Fusarium crown rot of wheat
Authors: Wang Jing , Xu Chunli , Xiao Wenqing , Wang Miaomiao , Han Xue , Sun Yang , Ge Beibei 
Published: February 2025

Fusarium crown rot of wheat, caused by Fusarium pseudograminearum, significantly affects the yield and quality of wheat worldwide. Here, Streptomyces noursei strain S86 (herein referred to as S86), was evaluated for its biocontrol efficacy and biochemical characteristics. Strain S86 was found to secrete cellulase, amylase and other enzymes. Whole genome sequencing and LC-MS analyses confirmed that S86 could produce toyocamycin, nystatin, anisomycin, natamycin, and other antimicrobial metabolites. The fermentation broth of S86 inhibited the growth of F. pseudograminearum and had broad-spectrum inhibitory activity against Rhizoctonia cerealis, Cochliobolus sativus, Fusarium graminearum, and Gaeumannomyces graminis var. graminis. A greenhouse experiment demonstrated that wheat seeds coated with S86 fermentation broth showed better control efficiency against Fusarium crown rot (68.33%), which was 22.63% higher than direct root irrigation with the S86 fermentation broth. These results indicate that S86 fermentation products have the potential to be developed as biological controls of Fusarium crown rot disease in the field.
The Role of the Lumbar Paravertebral Muscles in the Development of Short-term Residual Pain after Lumbar Fusion Surgery
Authors: Sun Haifu , Tang Wenxiang , You Xingyu , Deng Lei , Chen Liuyu , Qian Zhonglai , Yang Huilin , Zou Jun , Qiao Yusen , Liu Hao 
Published: February 2025

Study design.
A retrospective real-world study.

Objective.
Using machine learning models to identify risk factors for residual pain after PLIF in patients with degenerative lumbar spine disease.

Summary of Background Data.
Residual pain after PLIF is a frequent phenomenon, and the specific risk factors for residual pain are not known.

Materials and Methods.
Between June 2018 and March 2023, 936 patients with lumbar degenerative disease who underwent PLIF surgery were recruited. Group A (n=501) had <7 days of VAS ≥3 pain within 1 month post-PLIF, while Group B (n=435) had ≥7 days. Imaging outcomes included PMI, MMI, MMD, lumbar lordosis (LL), and LL improvement rate. Functional outcomes were assessed by VAS. Univariate and multivariate logistic regression analyses were used to determine the potential risk of short-term postoperative pain. Risk factors were identified using machine learning models and predicted whether residual pain would occur.

Results.
A total of 435 (46.5%) patients experienced residual postoperative pain. Independent risk factors included surgical segment, PMI, MMI, and depression level. The Random Forest Model model had an accuracy of 95.7%, a sensitivity of 96.4%, a specificity of 94.1%, and an F1 score of approximately 95.2% for predicting recurrent pain, indicating high reliability and generalizability.

Conclusions.
Our study reveals risk factors for the development of residual pain after PLIF. Compared to the group with residual pain, the group without pain had more robust paravertebral muscles, improved psychological characteristics and a greater LL improvement rate. These factors may represent targets for pre-operative and peri-operative optimization as a means to minimize the potential for residual pain following PLIF.
Lactated Ringer’s or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension
Authors: Gelbenegger Georg , Shapiro Nathan I. , Zeitlinger Markus , Jilma Bernd , Douglas Ivor S. , Jorda Anselm 
Published: February 2025

Objectives:
To assess whether initial fluid resuscitation with lactated Ringer’s solution compared with 0.9% saline is associated with improved clinical outcomes in patients with sepsis-induced hypotension.

Design:
Secondary analysis of the randomized controlled Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) trial.

Setting:
ICUs and emergency departments in 60 U.S. centers from March 2018 to January 2022.

Patients:
Participants from the CLOVERS trial. Adult patients with a suspected or confirmed infection and hypotension caused by sepsis.

Interventions:
Participants received 1–3 L of crystalloid fluid for initial fluid resuscitation before randomization. In this analysis, participants were categorized into a lactated Ringer’s group and a 0.9% saline group based on the fluid type predominantly used for the initial fluid resuscitation (i.e., ≥ 95% of pre-randomization fluid).

Measurements and Main Results:
Of 1563 participants with sepsis-induced hypotension included in the CLOVERS trial, 622 (39.8%) received lactated Ringer’s solution and 690 (44.1%) received 0.9% saline as solution for the initial fluid bolus. Death before discharge home by day 90 occurred in 76 of 622 participants (12.2%) in the lactated Ringer’s group and in 110 of 690 participants (15.9%) in the 0.9% saline group, resulting in an adjusted hazard ratio of 0.71 (95% CI, 0.51–0.99; p = 0.043). Patients receiving lactated Ringer’s solution had more hospital-free days at 28 days than those receiving 0.9% saline (16.6 ± 10.8 vs. 15.4 ± 11.4, respectively; adjusted mean difference, 1.6 d [95% CI, 0.4–2.8 d; p = 0.009]). Treatment with 0.9% saline was associated with higher levels of serum chloride and decreased levels of serum bicarbonate.

Conclusions:
Initial fluid resuscitation with lactated Ringer’s solution, compared with 0.9% saline, might be associated with improved survival in patients with sepsis-induced hypotension.
The Association Between Body Mass Index and Mortality Mediated by Medical and Mechanical Complications in Venovenous Extracorporeal Membrane Oxygenation
Authors: Hatton Kevin W. , Engoren Milo , Furfaro David , McCloskey Colin 
Published: February 2025

Objectives:
To estimate the associations between body mass index (BMI) and mortality and between BMI and complications in patients receiving venovenous extracorporeal membrane oxygenation (ECMO) and to estimate if any mortality association was mediated by complications.

Design:
Retrospective analysis of an international, multicenter registry.

Setting:
ICUs.

Patients:
Adults in the Extracorporeal Life Support Organization database who received venovenous ECMO between January 1, 2015, and December 31, 2021.

Interventions:
None.

Measurements and Main Results:
Logistic regression with BMI transformed using fractional polynomials was used to estimate the association between BMI and hospital mortality and between BMI and complications. Mediation analysis was used to estimate if the association between BMI and mortality was a direct effect or was mediated by complications. Of the 24,796 patient runs, 10,361 patients died (48%). After adjusting for confounders, we found nonlinear associations between BMI and mortality. Compared with BMI = 25 kg/m2, a BMI = 20 had an 11% higher risk of dying, odds ratio (OR) =1.11 (95% CI, 1.08–1.15); a BMI = 30 had an 8% lower risk, OR = 0.92 (95% CI, 0.90–0.95); and a BMI = 40 kg/m2 had an 18% lower risk of death OR = 0.82 (95% CI, 0.78–0.87). BMI was also associated with mechanical, renal, pulmonary, and neurologic complications. The association between BMI and mortality was both a direct effect and mediated via pulmonary complications, while mechanical, renal replacement therapy, and neurologic complications were suppressors having a negative association with improved mortality in patients with higher BMI.

Conclusions:
We confirmed that patients with higher BMI requiring venovenous ECMO were less likely to die. This finding was partially mediated by pulmonary complications and partially via a direct association between BMI and mortality. BMI was also associated with mechanical, renal replacement therapy, and neurologic complications that acted as suppressing mediators and were associated with increased mortality for increasing BMI despite the overall trend of improved survival.
p300 upregulates Ikur in atrial cardiomyocytes through activating NLRP3 inflammasome in hypertension
Authors: Zeng Long , Liu Panyue , Rao Fang , Du Zhimin , Xiao Haiyin , Yu Shenghuan , Deng Chunyu , Zhang Mengzhen , Liu Fangzhou , Zhu Rui , Deng Hai , Wu Shulin , Xue Yumei , Fang Xianhong , Wei Wei 
Published: February 2025

Abstract

Background:
The nucleotide-binding oligomerization domain [NOD-], leucine-rich repeats [LRR-], and Pyrin domain-containing protein 3 (NLRP3) inflammasome plays an essential role in hypertension-related atrial fibrillation (AF). p300 is involved in cardiovascular inflammation. In this study, we aimed to investigate the role of p300 in NLRP3 inflammasome activation and its subsequent impact on the Ikur current in angiotensin II (Ang II)-induced HL-1 cells and Ang II-infused mice.

Methods:
Expression levels of p300, Kv1.5, and NLRP3 in left atrial appendage (LAA) tissues from AF and sinus rhythm (SR) patients were detected by Western blot. A hypertension mouse model was established in p300 knockout (p300-KO) mice via Ang II infusion, and AF incidence was assessed by electrocardiogram (ECG) after rapid atrial pacing. In vitro, the expression level of p300 in HL-1 cells was modulated by adenoviral overexpression, curcumin (an inhibitor of p300) treatment, and smal interfering RNA (siRNA) knockdown. NLRP3 inflammasome activation was evaluated by Western blot and enzyme-linked immunosorbent assay, and electrophysiological properties of HL-1 cells were analyzed using whole-cell patch-clamp recordings. Co-immunoprecipitation assays were performed to investigate the interaction between p300 and nuclear factor kappa B (NF-κB).

Results:
The expression levels of p300, Kv1.5, and NLRP3 were found to be significantly higher in the LAA tissue of AF patients compared to SR patients. p300-KO decreased AF incidence in Ang II-infused mice by impairing NLRP3 inflammasome activation. p300-OE facilitated NLRP3 inflammasome activation, which subsequently increased the Ikur density and shortened the action potential duration of HL-1 cells. Both curcumin (p300 inhibitor) and p300-siRNA treatments reversed Ang II-induced atrial electrical remodeling and NLRP3 inflammasome activation. Moreover, co-immunoprecipitation showed that p300 interacts with NF-κB to promote NLRP3 inflammasome activation.

Conclusions:
p300 participates in hypertension-induced AF susceptibility by interacting with NF-κB to activate the NLRP3 inflammasome, which subsequently upregulates the transmembrane current of Ikur in atrial cardiomyocytes.
Outcome Predictors of Hardware Complications in Head and Neck Free Flap Reconstruction
Authors: Talwar Abhinav , Asthana Shravan , Silva-Nash Jennifer , Gharzai Laila A. , Samant Sandeep , Patel Urjeet , Stepan Katelyn 
Published: February 2025

Objectives:
Osteocutaneous free flap reconstruction can be complicated by hardware failure. The present study investigates the frequency and predictors of hardware failure in head and neck osteocutaneous reconstruction.

Methods:
Patients who underwent osteocutaneous head and neck free flap reconstruction between the years of 2014 and 2022 were identified at our institution. Hardware failure was defined as hardware infection, screw plate loosening, exposed hardware, migration, deformation, or fracture.

Results:
We identified 47 patients who met the inclusion criteria for this study. Common indications for intervention included squamous cell carcinoma (35, 74%) and osteoradionecrosis (8, 17%). Most operations used fibular flaps (31, 66%) or osteocutaneous radial forearm flaps (12, 26%). The median age at the time of reconstruction was 66 years (IQR: 59 to 72). In total, 17 (36%) patients experienced hardware failure in the postoperative period. On univariable analysis, estimated blood loss (P=0.01) and early postoperative infectious complication (P=0.03) were the only significant predictors of hardware failure. On multivariable analysis, these factors retained significance. Estimated blood loss had an OR of 1.004 (95% CI: 1.001-1.008; P=0.01), and infectious complication had an OR of 5.22 (95% CI: 1.28-24.84; P=0.03).

Conclusion:
The incidence of hardware failure among patients who undergo head and neck osteocutaenous free flap reconstruction is high (36%). Patients with infectious complications and high estimated blood loss may be more likely to develop hardware failure.

Level of Evidence:
Level III.