bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Abdominal Incision Type on Postoperative Pain and Quality of Life Following Hepatectomy
Authors: Watanabe Genki , Ishizawa Takeaki , Yamamoto Satoshi , Kokudo Takashi , Nishioka Yujiro , Ichida Akihiko , Akamatsu Nobuhisa , Kaneko Junichi , Arita Junichi , Hasegawa Kiyoshi 
Published: February 2021

AbstractBackgroundThe aim of this prospective study was to analyze the impact of abdominal incision type on postoperative pain and quality of life (QOL) in hepatectomy.MethodsIn patients undergoing hepatectomy by open, hybrid, or pure laparoscopic approaches, we classified abdominal incisions as: pure laparoscopic (LAP), midline (MID), J‐shaped (J), and J‐shaped incision plus thoracotomy (TRC). Postoperative pain was measured on postoperative day (POD) 3, 7, 30, and 90 using a visual analog scale (VAS). QOL was evaluated using the short‐form‐36 questionnaire preoperatively and on POD 30 and 90.ResultsWe categorized 165 patients into LAP (n = 9, 5%), MID (n = 21, 13%), J (n = 95, 58%), and TRC (n = 40, 24%) groups. Median VAS scores on PODs 3/7/30/90 were: LAP, 27.5/7.5/10/10; MID, 30/10/15/5; J, 50/27.5/20/10, and TRC, 50/30/30/19. The J and TRC groups had significantly higher VAS scores vs. MID on PODs 3 and 7; the LAP and MID groups did not differ significantly. No significant positive correlations were observed between incision length and postoperative VAS, when we stratified patients into two groups according to the presence or absence of a transverse incision. Physical QOL summary scores did not return to preoperative levels even on POD 90, in patients with an additional transverse incision. Mental QOL summary scores worsened with postoperative complications rather than with abdominal incision type.ConclusionsTransverse incisions, rather than incision length, led to worse midline incision pain and poorer QOL recovery post‐hepatectomy. A hybrid approach may be a considerable option when pure laparoscopic hepatectomy is technically difficult.Trial registrationThis study was registered in the UMIN Clinical Trials Registry (registration number: UMIN000017467; http://www.umin.ac.jp/ctr/index.htm)
Hereditary Medullary Thyroid Carcinoma: Genotype, Phenotype and Outcomes in a North Indian Cohort
Authors: Valiveru Ramya C , Agarwal Gaurav , Agrawal Vinita , Mayilvaganan Sabaretnam , Chand Gyan , Mishra Anjali , Agarwal Amit , Mishra Saroj Kanta , Bhatia Eesh 
Published: February 2021

AbstractBackgroundAggressiveness of hereditary medullary thyroid carcinoma (hMTC) has been conventionally described to correlate with American Thyroid Association (ATA) risk groups based on RET mutations. Recent evidence increasingly contradicts this notion. We studied the RET genotype and its correlation with disease phenotype and survival outcomes in a cohort of hMTC patients.MethodsIn a retrospective cohort of 55 hMTC patients from 23 families treated at a north Indian tertiary care institute over 15‐years, RET genotype was correlated with disease phenotype (clinical, biochemical, and pathological attributes) and outcomes in terms of biochemical cure (normalization of serum calcitonin), structural cure, overall survival (OS) and disease specific survival (DSS).ResultsForty‐nine patients had Multiple Endocrine Neoplasia (MEN)‐type 2A syndrome, 02 had MEN‐2B, and 4 had familial MTC. Two patients belonged to highest ATA risk, 41 to high‐risk, and 12 to moderate risk categories. Age of the patients or stage of disease at presentation did not differ significantly between the ATA risk groups. Though the baseline serum calcitonin was significantly higher in highest risk category, the biochemical cure rates were not significantly different. At a median follow up of 48 months (Inter‐quartile range 18–84, range 12–192) structural cure rates in ATA moderate and high risk groups were significantly higher than highest risk group (p = 0.04). No significant difference in OS between the three ATA groups of hMTC among the patients who underwent surgical treatment was observed (p = 0.098).ConclusionsThe ATA moderate and high risk groups have better structural cure rates compared to ATA highest risk group. The biochemical cure and overall survival rates did not significantly differ between ATA risk‐groups, and were impacted by the disease stage at presentation. The current ATA risk‐groups do not reliably predict the outcomes in terms of biochemical cure and survival in hMTC patients.
Subcutaneous daratumumab in Asian patients with heavily pretreated multiple myeloma: subgroup analyses of the noninferiority, phase 3 COLUMBA study
Authors: Iida Shinsuke , Ishikawa Takayuki , Min Chang Ki , Kim Kihyun , Yeh Su Peng , Usmani Saad Z. , Mateos Maria-Victoria , Nahi Hareth , Heuck Christoph , Qin Xiang , Parasrampuria Dolly A. , Gries Katharine S. , Qi Ming , Bahlis Nizar , Ito Shigeki 
Published: February 2021

AbstractThe phase 3 COLUMBA study demonstrated noninferiority of subcutaneous daratumumab (DARA SC) to intravenous daratumumab (DARA IV) in relapsed or refractory multiple myeloma. We present a subgroup analysis of Asian patients from COLUMBA. Eligible patients had ≥ 3 prior lines of therapy, including a proteasome inhibitor and an immunomodulatory drug, or were double refractory. Co-primary endpoints were overall response rate (ORR) and maximum trough concentration (Ctrough). Secondary endpoints included rates of infusion-related reactions, progression-free survival, and patient-reported satisfaction with therapy. Sixty-seven Asian patients (DARA SC, n = 30; DARA IV, n = 37) were randomized, including 42 Japanese patients (DARA SC, n = 18; DARA IV, n = 24). Comparable ORRs for DARA SC versus DARA IV were seen in the Asian cohort (66.7% vs 43.2%) and Japanese-only cohort (61.1% vs 54.2%), including patients weighing ≤ 65 kg. Similarity of Ctrough was seen in both Asian and Japanese-only cohorts; the ratio of the geometric mean of the Ctrough concentrations for DARA SC/DARA IV was 143.96% (90% confidence interval (CI), 112.03–185.00%) and 148.02% (90% CI, 113.32–193.34%), respectively. The Asian cohort (both treatment groups) and Japanese-only cohort (DARA SC group) experienced higher rates of grade 3/4 cytopenias compared with the global COLUMBA population, occurring predominantly in patients of low bodyweight; no patients discontinued treatment due to cytopenias. The Cancer Therapy Satisfaction Questionnaire results generally favored DARA SC. In the Asian and Japanese-only cohorts, DARA SC was comparable to DARA IV. The efficacy, pharmacokinetic, safety, and satisfaction results were generally consistent with the global COLUMBA population regardless of patient bodyweight. ClinicalTrials.gov Identifier: NCT03277105
Serotype Distribution and Characteristics of the Minimum Inhibitory Concentrations of Streptococcus pneumoniae Isolated from Pediatric Patients in Kunming, China
Authors: Ma Mingbiao , Yuan Mei , Li Ming , Li Xiaojuan , Huang Hailin , Wang Haiping , Li Jue , Du Tingyi , Huang Rongwei 
Published: February 2021

AbstractStreptococcus pneumoniae (S. pneumoniae) is the main conditional pathogen of acute respiratory infection in infants, children, and older adults worldwide. It was great significant to identify the epidemic characteristics of serotypes and antibiotic susceptibility for the prevention and treatment of S. pneumoniae diseases. This research assessed the serotype distribution and the minimum inhibitory concentrations (MICs) of S. pneumoniae isolated from pediatric patients to provide information on the epidemiology and antibiotic resistance of S. pneumoniae in Kunming, China. A total of 140 S. pneumoniae isolates were collected from pediatric patients at Kunming Children’s Hospital from January 2016 to October 2017. Serotype identification was done by Quellung reaction and multiplex polymerase chain reaction. MICs were determined by E-test. 140 isolates distributed in 13 types of serotypes. The top-three prevalent serotypes were 19F, 19A, and 6B. The immunization coverage rate of 13-valent pneumococcal conjugate vaccine (PCV) was relatively higher and should be introduced into the vaccination program in the region. MIC50 of penicillin, ceftriaxone, and levofloxacin was 1 μg/mL. MIC50 for meropenem and vancomycin was 0.38 μg/mL. MIC90 of penicillin, ceftriaxone, and levofloxacin was 1.5 μg/mL and that of meropenem and vancomycin was 0.5 μg/mL. The MIC90 of erythromycin was > 256 μg/mL. In summary, S. pneumoniae had low resistance rates to penicillin, ceftriaxone, levofloxacin, vancomycin, and meropenem, and these antibiotics could be the first-line agents for children with pneumococcal infections in Kunming.
Role of high-density EEG (hdEEG) in pre-surgical epilepsy evaluation in children: case report and review of the literature
Authors: Quintiliani Michela , Bianchi Federico , Fuggetta Filomena , Chieffo Daniela Pia Rosaria , Ramaglia Antonia , Battaglia Domenica Immacolata , Tamburrini Gianpiero 
Published: February 2021

AbstractIntroductionElectrical source imaging (ESI) and especially hdEEG represent a noninvasive, low cost and accurate method of localizing epileptic zone (EZ). Such capability can greatly increase seizure freedom rate in surgically treated drug resistant epilepsy cases. Furthermore, ESI might be important in intracranial record planning.Case reportWe report the case of a 15 years old boy suffering from drug resistant epilepsy with a previous history of DNET removal. The patient suffered from heterogeneous seizure semiology characterized by anesthesia and loss of tone in the left arm, twisting of the jaw to the left and dysarthria accompanied by daze; lightheadedness sometimes associated with headache and dizziness and at a relatively short time distance negative myoclonus involving the left hand. Clinical evidence poorly match scalp and video EEG monitoring thus requiring hdEEG recording followed by SEEG to define surgical target. Surgery was also guided by ECoG and obtained seizure freedom.DiscussionESI offers an excellent estimate of EZ, being hdEEG and intracranial recordings especially important in defining it. We analyzed our results together with the data from the literature showing how in children hdEEG might be even more crucial than in adults due to the heterogeneity in seizures phenomenology. The complexity of each case and the technical difficulties in dealing with children, stress even more the importance of a noninvasive tool for diagnosis. In fact, hdEEG not only guided in the presented case SEEG planning but may also in the future offer the possibility to replace it.
The effect of GMFCS level, age, sex, and dystonia on multi-dimensional outcomes after selective dorsal rhizotomy: prospective observational study
Authors:   Alder Hey Physiotherapy Group, Gillespie Conor Scott , George Alan Matthew , Hall Benjamin , Toh Steven , Islim Abdurrahman Ismail , Hennigan Dawn , Kumar Ram , Pettorini Benedetta 
Published: February 2021

Abstract
Purpose
Investigate the effect of age category (1–9 years vs 10–18 years), sex, Gross Motor Function Classification System (GMFCS) level, and presence of dystonia on changes in eight function test parameters 24 months after selective dorsal rhizotomy (SDR).

Methods
Prospective, single-center study of all children aged 3–18 years with bilateral cerebral palsy with spasticity who underwent SDR at a tertiary pediatric neurosurgery center between 2012 and 2019. A linear mixed effects model was used to assess longitudinal changes.

Results
From 2012 to 2019, 42 children had follow-up available at 24 months. Mean GMFM-66 scores increased after SDR (mean difference 5.1 units: 95% CI 3.05–7.13, p < 0.001). Statistically significant improvements were observed in CPQoL, PEDI Self-care and Mobility, 6MWT, Gillette, and MAS scores. There was no significant difference in the improvements seen for age category, sex, GMFCS level, and presence of dystonia for most of the parameters tested (5/8, 6/8, 5/8, and 6/8 respectively).

Conclusion
SDR may improve gross and fine motor function, mobility and self-care, quality of life, and overall outcome based on extensive scoring parameter testing at 24 months. Atypical patient populations may benefit from SDR if appropriately selected. Multi-center, prospective registries investigating the effect of SDR are required.
Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside
Authors: Sárközy Márta , Varga Zoltán , Gáspár Renáta , Szűcs Gergő , Kovács Mónika G. , Kovács Zsuzsanna Z. A. , Dux László , Kahán Zsuzsanna , Csont Tamás 
Published: February 2021

AbstractCancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tumor cells; however, it may have deleterious side effects on the surrounding normal tissues. The syndrome of unwanted cardiovascular adverse effects of thoracic RT is termed radiation-induced heart disease (RIHD), and the risk of developing RIHD is a critical concern in current oncology practice. Premature ischemic heart disease, cardiomyopathy, heart failure, valve abnormalities, and electrical conduct defects are common forms of RIHD. The underlying mechanisms of RIHD are still not entirely clear, and specific therapeutic interventions are missing. In this review, we focus on the molecular pathomechanisms of acute and chronic RIHD and propose preventive measures and possible pharmacological strategies to minimize the burden of RIHD.
Tremor measurements in a 22-year cohort study of workers exposed to hand-held vibrating tools
Authors: Bast-Pettersen Rita , Nordby Karl-Christian , Wastensson Gunilla , Aarhus Lisa 
Published: February 2021

AbstractObjectivesThe objectives of this cohort study were to evaluate possible long-term effects of occupational exposure to hand-arm vibration (HAV) in terms of increased tremor. The aims were to evaluate whether exposure during follow-up, baseline hand-arm vibration syndrome (HAVS), baseline manual dexterity or current medical conditions or life-style habits might be associated with increased tremor. A further aim was to compare two different activation conditions: postural vs rest tremor.MethodsForty men (current age: 60.4 years) who had previously worked as manual workers in a specialized engineering and construction company enrolled in the study. Their hand functions had been examined in 1994. At the baseline examination, 27 had been diagnosed with HAVS, while 13 were not exposed. The follow-up examination in 2016–2017 comprised the CATSYS Tremor Pen®for measuring postural and rest tremor and the Grooved Pegboard Test for assessing manual dexterity. Blood samples were taken for assessing biomarkers that might have impact on tremor.ResultsNeither cumulative exposure to HAV during follow-up nor HAVS at baseline were associated with increased tremor. A test for manual dexterity at baseline was significantly associated with increased tremor (Tremor Intensity) at follow-up. Blood markers of current medical conditions and tobacco consumption were associated with increased tremor. Rest tremor frequency was higher than postural tremor frequency (p < 0.001).ConclusionsThe main findings of this 22-year cohort study were no indications of long-term effects on tremor related to HAV exposure and previous HAVS status. However, baseline manual dexterity was significantly associated with increased tremor at follow-up. Activation conditions (e.g., hand position) are important when testing tremor.
The Fuzzy Kinetics Index: an indicator conflating cardiorespiratory kinetics during dynamic exercise
Authors: Drescher U. 
Published: February 2021

Abstract
Purpose
The aim of the present study was to develop a novel index using fuzzy logic procedures conflating cardiorespiratory and pulmonary kinetics during dynamic exercise as a representative indicator for exercise tolerance.

Methods
Overall 69 data sets were re-analyzed: (age: 29 ± 1.2 y [mean ± SEM], height: 179 ± 1.0 cm; body mass: 78 ± 1.4 kg; peak oxygen uptake ($$\dot {\text{V}}$$

V
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̇O2peak): 48 ± 1.1 ml·min−1·kg−1), that comprised pseudo random binary sequence work rate (WR) changes between 30 and 80 W on a cycle ergometer, with additional voluntary exhaustion to estimate $$\dot {\text{V}}$$

V
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O2peak. Heart rate (HR), stroke volume (SV) and gas exchange (pulmonary oxygen uptake ($$\dot {\text{V}}$$

V
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O2pulm)) were measured beat-to-beat and breath-by-breath, respectively. For estimation of muscle oxygen uptake ($$\dot {\text{V}}$$

V
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O2musc) kinetics and for the analysis of kinetic responses of the parameters of interest (perfusion ($$\dot {\text{Q}}$$

Q
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= HR·SV), $$\dot {\text{V}}$$

V
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O2pulm, $$\dot {\text{V}}$$

V
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O2musc) the approach of Hoffmann et al. (2013) was applied. For calculation of the Fuzzy Kinetics Index $$\dot {\text{Q}}$$

Q
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, $$\dot {\text{V}}$$

V
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O2pulm, and $$\dot {\text{V}}$$

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O2musc were used as input variables for the subsequent fuzzy- and defuzzyfication procedures.

Results
For both absolute and relative $$\dot {\text{V}}$$

V
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O2peak a significant correlation has been observed with FKI, whereas the correlation coefficient is higher for relative (r = 0.430; p < 0.001; n = 69) compared to absolute $$\dot {\text{V}}$$

V
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O2peak (r = 0.358; p < 0.01; n = 69). No significant correlations have been found between FKI and age, height or body mass (p > 0.05 each).

Conclusions
The significant correlations between FKI and $$\dot {\text{V}}$$

V
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O2peak represent a physiological connection between the regulatory and the capacitive system and its exercise performance. In turn, the application of FKI can serve as an indicator for healthy participants to assess exercise tolerance and sport performance.
Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens
Authors: Smeets Silke , De Paep Diedert Luc , Stangé Geert , Verhaeghen Katrijn , Van der Auwera Bart , Keymeulen Bart , Weets Ilse , Ling Zhidong , in’t Veld Peter , Gorus Frans 
Published: February 2021

AbstractAutoantibodies against islet cell antigens are routinely used to identify subjects at increased risk of symptomatic type 1 diabetes, but their relation to the intra-islet pathogenetic process that leads to positivity for these markers is poorly understood. We screened 556 non-diabetic organ donors (3 months to 24 years) for five different autoantibodies and found positivity in 27 subjects, 25 single- and two double autoantibody-positive donors. Histopathological screening of pancreatic tissue samples showed lesion characteristic for recent-onset type 1 diabetes in the two organ donors with a high-risk profile, due to their positivity for multiple autoantibodies and HLA-inferred risk. Inflammatory infiltrates (insulitis) were found in a small fraction of islets (<5%) and consisted predominantly of CD3+CD8+ T-cells. Islets with insulitis were found in close proximity to islets devoid of insulin-positivity; such pseudo-atrophic islets were present in multiple small foci scattered throughout the pancreatic tissue or were found to be distributed with a lobular pattern. Relative beta cell area in both single and multiple autoantibody-positive donors was comparable to that in autoantibody-negative controls. In conclusion, in organ donors under age 25 years, insulitis and pseudo-atrophic islets were restricted to multiple autoantibody-positive individuals allegedly at high risk of developing symptomatic type 1 diabetes, in line with reports in older age groups. These observations may give further insight into the early pathogenetic events that may culminate in clinically overt disease.
A regularity criterion for a 2D tropical climate model with fractional dissipation
Authors: Bisconti Luca 
Published: February 2021

AbstractTropical climate model derived by Frierson et al. (Commun Math Sci 2:591–626, 2004) and its modified versions have been investigated in a number of papers [see, e.g., Li and Titi (Discrete Contin Dyn Syst Series A 36(8):4495–4516, 2016), Wan (J Math Phys 57(2):021507, 2016), Ye (J Math Anal Appl 446:307–321, 2017) and more recently Dong et al. (Discrete Contin Dyn Syst Ser B 24(1):211–229, 2019)]. Here, we deal with the 2D tropical climate model with fractional dissipative terms in the equation of the barotropic mode u and in the equation of the first baroclinic mode v of the velocity, but without diffusion in the temperature equation, and we establish a regularity criterion for this system.
The impact of biased sampling of event logs on the performance of process discovery
Authors: Fani Sani Mohammadreza , van Zelst Sebastiaan J. , van der Aalst Wil M. P. 
Published: February 2021

AbstractWith Process discovery algorithms, we discover process models based on event data, captured during the execution of business processes. The process discovery algorithms tend to use the whole event data. When dealing with large event data, it is no longer feasible to use standard hardware in a limited time. A straightforward approach to overcome this problem is to down-size the data utilizing a random sampling method. However, little research has been conducted on selecting the right sample, given the available time and characteristics of event data. This paper systematically evaluates various biased sampling methods and evaluates their performance on different datasets using four different discovery techniques. Our experiments show that it is possible to considerably speed up discovery techniques using biased sampling without losing the resulting process model quality. Furthermore, due to the implicit filtering (removing outliers) obtained by applying the sampling technique, the model quality may even be improved.
Association between kidney stones and risk of developing stroke: a meta-analysis
Authors: Yuan Min , Zhou Huang-Yan , Hu Fan , Liu Shi-Ying , Rao Wei , Wu Ling-Feng , Nie Hong-Bing , Cao Wen-Feng 
Published: February 2021

Abstract
Background
Many studies have described the relationship between kidney stones and stroke, but the results are controversial, so we conducted this meta-analysis to estimate the relationship between kidney stones and the risk of developing stroke.

Methods
Studies were marked with a comprehensive search of PubMed, EMBASE, Google, and ISI Web of Science databases through 25 March 2020. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted, and a random-effects model or fix-effects model was used to compute the pooled combined risk estimate. Heterogeneity was reported as I2. We performed subgroup and sensitivity analysis to assess potential sources of heterogeneity.

Results
Eight studies of seven articles involving 3,526,808 participants were included in the meta-analysis. Overall, kidney stones were associated with a moderate risk of stroke incidence (HR, 1.24; 95% CI, 1.11–1.40; I2=79.6%; p=0.000). We conducted a sensitivity analysis by removing the studies that had a high risk of bias. Heterogeneity subsequently decreased significantly, while an increased risk of stroke in patient with kidney stones was again demonstrated (HR, 1.16; 95% CI, 1.11–1.23; I2=28.7%; p=0.000). Stratifying analysis showed that the results were more pronounced for ischemic stroke (HR, 1.14; 95% CI, 1.08–1.22; I2=15.6%; p=0.00) and the follow-up duration ≥10 years (HR, 1.18; 95% CI, 1.10–1.27; I2=31.6%; p=0.003).

Conclusions
Our meta-analysis suggests that patients with kidney stones may have a modestly increased risk of developing stroke, especially in ischemic stroke. More large-scaled and clinical trials should be done to identify the relative impact of kidney stones on stroke outcomes in the future.