bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROLE OF WATER TRANSPORT IN THE DEVELOPMENT OF TOURISM IN THE NORTHERN BLACK SEA OF UKRAINE
Authors: Storozhuk Svitlana , Pronchenko Andrii 
Published: December 2021

The article is devoted to water transport and its role in the tourism sector. Water transport is one of the oldest forms of transport and remained the most important until the advent of transcontinental railways in the second half of the 19th century. It plays a huge role in the tourism sector and is used quite actively. The most significant advantages are a high level of comfort, a large volume of one-time loading of ships, the possibility of implementing various types and purposes of tourism (educational, business tourism, educational, shop tourism).
The main type of sea and river transportation in tourism is cruises - travel in a vicious circle with radial trips from ports to the interior regions of countries. The main activity of water transport is to meet the needs of people in passenger transportation, as well as the demand for recreation during a sea trip.
More than 25 years ago from Odessa it was easy to quickly and inexpensively get to anywhere in the Black Sea; a powerful fleet of passenger hydrofoils successfully competed with trains and aircraft throughout the Northern Black Sea region. By the beginning of the 1980s, hydrofoils "Kometa" and "Kolkhida" sailed from Odessa to Kherson, Kakhovka, Zaporozhye, Nikolaev, and also towards Crimea – to Skadovsk, Evpatoria, Sevastopol, Yalta, Kerch, Novorossiysk and Sochi. "Comets" and "Colchis" covered the distance along the Odessa – Kherson line in 2 hours and 40 minutes, in contrast to automobile transport – 4 hours, which was much more comfortable and faster. And boats and sea trams running along the coast of the Odessa Gulf, from Kryzhanovka to Chernomorka, were one of Odessa's calling cards from the post-war times until the 1990s, when the history of Odessa sea trams and hydrofoils ended.
Sea transport and water travel play a huge role in the tourism sector all over the world, therefore their revival is an integral part in the development and modernization of the tourism sector of the Northern Black Sea region. In the 2000s and 2010s, there were attempts to revive coastal passenger shipping in the Black Sea, but not as successful. The main obstacle to the return of high-speed coastal passenger shipping to Odessa is the seasonality and dependence on the weather, which makes water transport not as stable as the railway. Despite this, "Rockets" and "Komets" do not have competition in speed with any bus and railway on such river and sea directions as Nikolaev, Kherson, Zaporozhye, Dnepropetrovsk, Izmail, etc. Moreover, it will serve the development of domestic and foreign tourism.
Olfactory Functions Difference on Gas Station Workers Using Sniffin’ Sticks Test
Authors: Sagala Irwan pernandi , Munir Delfitri , Rambe Andrina Y.M 
Published: December 2021

ABSTRACT
Background: Chronic exposure of volatile substances can cause the impaired olfactory function.
Objective: To identify the difference of olfactory function at Gas Station workers in Medan city.
Method: Cross-sectional analitic study. A total of 80 persons consisting of 40 gas station operators and 40 non-operators who fulfilled the inclusion criteria. The applied statistical analysis was Mann Whitney, Fisher's Exact, Chi Square, T independent, Spearman with 95% confidence level.
Result: Proportion of the impaired olfactory function in the gas station operator group by 77.5% and non-operator group by 0%. Significant correlation was obtained between age, duration of work with the impaired olfactory function (p = 0,047, p = 0,001). The gas station operators will suffer the impaired olfactory function if they works for ≥ 3.89 years.
Conclusion: There were differences of olfactory functions on the gas station workers by using Sniffin 'Sticks Test.
PENGARUH BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI MELALUI KOMITMEN ORGANISASI SEBAGAI VARIABEL MEDIASI PADA UPTP KEMENTERIAN KETENAGAKERJAAN RI DI KENDARI
Authors: Nurseta Esty , Kamaluddin Murdjani , Palilati Alida 
Published: December 2021

This research aims to examine and explain the effect of organizational culture on employee performance through organizational commitment as a mediating as a mediating variable at the UPTP of Ministry of Manpower in Kendari. The population in this study are all government civil at the UPTP of Ministry of Manpower in Kendari totalling 62 respondents. The sampling technique in this study was carried out by means of the census technique so that the entire population was used as the research sample. Methods oof data collection were used questionnaire. Technique of data anlysis used is Partial Least Square (PLS).The results showed that organizational culture has a positive and significant effect on organizational commitment, organizational commitment has a positive and significant effect on employee performance, organizational culture has a positive and significant effects on employee commitment, and commitment organizational as a partial mediate of the effects organizational culture on employee performance.
Predicting Phrenic Nerve Palsy in Patients Undergoing Atrial Fibrillation Ablation With the Cryoballoon—Does Sex Matter?
Authors: Pott Alexander , Wirth Hagen , Teumer Yannick , Weinmann Karolina , Baumhardt Michael , Schweizer Christiane , Markovic Sinisa , Buckert Dominik , Bothner Carlo , Rottbauer Wolfgang , Dahme Tillman 
Published: December 2021

Background: Phrenicus nerve palsy (PNP) is a typical complication during pulmonary vein isolation (PVI) using the cryoballoon with the ominous potential to counteract the clinical benefit of restored sinus rhythm. According to current evidence incidence of PNP is about 5–10% of patients undergoing Cryo-PVI and is more frequent during ablation of the RSPV compared to the RIPV. However, information on patient specific characteristics predicting PNP and long-term outcome of patients suffering from this adverse event is sparse.Aim of the Study: To evaluate procedural and clinical characteristics of AF patients with PNP during cryoballoon PVI compared to patients without PNP.Methods and Results: Between 2013 and 2019 we included 632 consecutive AF patients undergoing PVI with the cryoballoon in our study. 84/632 (13.3%) patients experienced a total number of 89 PNP during the ablation procedure. 75/89 (84%) cryothermal induced PNP recovered until the end of the procedure (transient PNP, tPNP), whereas 14/89 (16%) PNP hold beyond the end of the procedure (non-transient PNP, ntPNP). Using multivariate logistic regression, we found that sex and BMI are strong and independent predictors of cryothermal induced non-transient PNP during cryoballoon PVI with an odds ratio of 3.9 (CI: 95%, 1.1–14.8, p = 0.04) for female gender. Interestingly, all patients (14/14, 100%) with a non-transient PNP experienced complete PNP resolution after a mean recovery time of 68 ± 79 days.Conclusion: Our data indicate for the first time, that female sex and lower BMI are independent predictors for non-transient PNP caused by cryoballoon PVI. Fortunately, during follow up all PNP patients resolved completely with a median recovery time of 35 days.
Theoretical Insight Into Diamond Doping and Its Possible Effect on Diamond Tool Wear During Cutting of Steel
Authors: Hao Li , Manzhos Sergei , Zhang Zhijun 
Published: December 2021

Natural diamond tools experience wear during cutting of steel. As reported in our previous work, Ga doping of diamond has an effect on suppressing graphitization of diamond which is a major route of wear. We investigate interstitial and substitutional dopants of different valence and different ionic radii (Ga, B, and He) to achieve a deeper understanding of inhibiting graphitization. In this study, ab initio calculations are used to explore the effects of three dopants that might affect the diamond wear. We consider mechanical effects via possible solution strengthening and electronic effects via dopant-induced modifications of the electronic structure. We find that the bulk modulus difference between pristine and doped diamond is clearly related to strain energies. Furthermore, boron doping makes the resulting graphite with stable sp2 hybridization more perfect than diamond, but Ga-doped diamond needs 2.49 eV to form the two graphene-like layers than only one layer, which would result in the suppressed graphitization and reduced chemical wear of the diamond tool.
Role of Abdominal Aortic Balloon Placement in Planned Conservative Management of Placenta Previa With Placenta Increta or Percreta
Authors: Lu Ruihui , Chu Ran , Wang Qiannan , Xu Yintao , Zhao Ying , Tao Guowei , Li Qi , Ma Yuyan 
Published: December 2021

Background: We investigated the role of balloon placement in the abdominal aorta (BPAA) in planned conservative management of placenta previa with placenta increta or percreta and the effects of BPAA on perinatal adverse maternal events.Methods: This retrospective case-control study included women with placenta previa (increta or percreta), who underwent pregnancy termination at the Qilu Hospital of Shandong University between January 2016 and June 2019. Patients were categorized into the BPAA and non-BPAA groups based on the BPAA placement before delivery. The Chi-square and non-parametric rank-sum tests were used for the intergroup comparison of patient characteristics. The propensity score matching algorithm was used to minimize the intergroup differences in clinical characteristics. Logistic regression analysis was used to identify the factors associated with a high risk of adverse pregnancy outcomes. The area under the receiver operating characteristic curve [area under the curve (AUC)] was used to evaluate the classification of the selected high-risk factors.Results: The study included 260 patients, and 104 patients were identified after propensity score matching. In the post-matched cohort, intraoperative blood loss was significantly lower in the BPAA than in the non-BPAA group (median 1,000 vs. 2,250 ml, P &lt; 0.001). Intraoperative B-Lynch suture was performed in fewer patients in the BPAA (15.4 vs. 34.6%, P = 0.024) than in the non-BPAA group. The packed red blood cell (PRBC) transfusion rate was lower in the BPAA group (median 4 vs. 8 units, P &lt; 0.001). Overall, 46 (45.1%) patients developed adverse maternal events; however, the rate of adverse maternal events was lower in the BPAA group (19.6 vs. 80.4%, P &lt; 0.001). No ligation of the ascending branch of the uterine artery (P = 0.034), no BPAA (P &lt; 0.001), intraplacental vascular lacunae (P = 0.046), and cervical hypervascularity (P = 0.001) were associated with a high risk of adverse perinatal maternal events. The AUC of the high-risk factors was 0.89 in the post-matched and 0.76 in the pre-matched cohorts.Conclusion: Planned conservative management using BPAA significantly minimized the intraoperative blood loss, the need for a B-Lynch suture, and PRBC transfusion in patients with severe placenta accreta spectrum and placenta previa.
High Circulating Sonic Hedgehog Protein Is Associated With Poor Outcome in EGFR-Mutated Advanced NSCLC Treated With Tyrosine Kinase Inhibitors
Authors: Takam Kamga Paul , Swalduz Aurélie , Costantini Adrien , Julié Catherine , Emile Jean-François , Pérol Maurice , Avrillon Virginie , Ortiz-Cuaran Sandra , de Saintigny Pierre , Giroux-Leprieur Etienne 
Published: December 2021

IntroductionGrowing preclinical evidence has suggested that the Sonic hedgehog (Shh) pathway is involved in resistance to tyrosine kinase inhibitor (TKI) therapy for EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC). However, little is known concerning the prognostic value of this pathway in this context.Materials and MethodsWe investigated the relationship between plasma levels of Shh and EGFRm NSCLC patients’ outcome with EGFR TKIs. We included 74 consecutive patients from two institutions with EGFRm advanced NSCLC treated by EGFR TKI as first-line therapy. Plasma samples were collected longitudinally for each patient and were analyzed for the expression of Shh using an ELISA assay. The activation of the Shh–Gli1 pathway was assessed through immunohistochemistry (IHC) of Gli1 and RT-qPCR analysis of the transcripts of Gli1 target genes in 14 available tumor biopsies collected at diagnosis (baseline).ResultsAmong the 74 patients, only 61 had baseline (diagnosis) plasma samples, while only 49 patients had plasma samples at the first evaluation. Shh protein was detectable in all samples at diagnosis (n = 61, mean = 1,041.2 ± 252.5 pg/ml). Among the 14 available tumor biopsies, nuclear expression of Gli1 was observed in 57.1% (8/14) of patients’ biopsies. Shh was significantly (p &lt; 0.05) enriched in youth (age &lt; 68), male, nonsmokers, patients with a PS &gt; 1, and patients presenting more than 2 metastatic sites and L858R mutation. Higher levels of Shh correlated with poor objective response to TKI, shorter progression-free survival (PFS), and T790M-independent mechanism of resistance. In addition, the rise of plasma Shh levels along the treatment was associated with the emergence of drug resistance in patients presenting an initial good therapy response.ConclusionThese data support that higher levels of plasma Shh at diagnosis and increased levels of Shh along the course of the disease are related to the emergence of TKI resistance and poor outcome for EGFR-TKI therapy, suggesting that Shh levels could stand both as a prognostic and as a resistance biomarker for the management of EGFR-mutated NSCLC patients treated with EGFR-TKI.
Evaluation of the Efficacy and Safety of a Compound of Micronized Flavonoids in Combination With Vitamin C and Extracts of Centella asiatica, Vaccinium myrtillus, and Vitis vinifera for the Reduction of Hemorrhoidal Symptoms in Patients With Grade II and III Hemorrhoidal Disease: A Retrospective Real-Life Study
Authors: Gravina Antonietta G. , Pellegrino Raffaele , Facchiano Angela , Palladino Giovanna , Loguercio Carmelina , Federico Alessandro 
Published: December 2021

Background and Aim: Several evidences have shown how, in hemorrhoidal disease, phlebotonic flavonoid agents such as quercetin reduce capillary permeability by increasing vascular walls resistance, how rutin and vitamin C have antioxidant properties, and that Centella asiatica has reparative properties towards the connective tissue. A retrospective study was designed in order to evaluate the efficacy and safety of a compound consisting of micronized flavonoids in combination with vitamin C and extracts of C. asiatica, Vaccinium myrtillus, and Vitis vinifera for grade II and III hemorrhoidal disease.Patients and Methods: Data of 49 patients, over 18, who were following a free diet regimen, not on therapy with other anti-hemorrhoid agents, treated with a compound consisting of 450 mg of micronized diosmin, 300 mg of C. asiatica, 270 mg of micronized hesperidin, 200 mg of V. vinifera, 160 mg of vitamin C, 160 mg of V. myrtillus, 140 mg of micronized quercetin, and 130 mg of micronized rutin (1 sachet or 2 tablets a day) for 7 days were collected. Hemorrhoid grade according to Goligher’s scale together with anorectal symptoms (edema, prolapse, itching, thrombosis, burning, pain, tenesmus, and bleeding) both before treatment (T0) and after 7 days of therapy (T7) were collected. Primary outcomes were the reduction of at least one degree of hemorrhoids according to Goligher’s scale assessed by proctological examination and compound safety. The secondary outcome was the reduction of anorectal symptoms assessed by questionnaires administered to patients.Results: Forty-four patients (89.8%) presented a reduction in hemorrhoidal grade of at least one grade (p &lt; 0.001). No adverse events with the use of the compound were noted. A significant reduction was observed in all anorectal symptoms evaluated (p &lt; 0.05). No predictors of response to the compound were identified among the clinical and demographic variables collected.Conclusion: The compound analyzed was effective and safe for patients with grade II and III hemorrhoidal disease according to Goligher’s scale.
A Novel Titanium Cranioplasty Technique of Marking the Coronal and Squamosoparietal Sutures in Three-Dimensional Titanium Mesh as Anatomical Positioning Markers to Increase the Surgical Accuracy and Reduce Postoperative Complications
Authors: Xie Bing-Sen , Wang Fang-Yu , Zheng Shu-Fa , Lin Yuan-Xiang , Kang De-Zhi , Fang Wen-Hua 
Published: December 2021

Objective: The objective of this research is to modify the titanium cranioplasty (Ti-CP) technique to increase the surgical accuracy and preliminarily verify the effectiveness and safety of this improvement.Methods: We developed a novel technique of marking the coronal and squamosoparietal sutures in three-dimensional (3D) titanium mesh as anatomical positioning markers and designed a prospective trial in patients with a unilateral frontotemporoparietal skull defect. Patients were randomly divided into two groups by the presence or absence of the anatomical positioning markers, and the therapeutic effects of these two groups were compared.Results: Forty-four patients were included in this study, including 28 (64%) males and 16 (36%) females. The mean age was 44.8 ± 15.2 years (range, 13–75 years). Overall postoperative complication rate of the intervention group (18%) was significantly (P = 0.03) lower than the control group (50%). Surgical accuracy of the intervention group (97.8%) was significantly (P &lt; 0.001) higher than the control group (94%). Visual analog scale for cosmesis (VASC) of the intervention group (8.4) was significantly (P &lt; 0.001) higher than the control group (7). The overall postoperative complication rate was 34%. Multivariate analyses showed that surgical accuracy &lt;95.8% (OR = 19.20, 95% CI = 3.17–116.45, P = 0.001) was significantly associated with overall postoperative complications. Independent predictor of overall postoperative complications was surgical accuracy (OR = 0.57, 95% CI = 0.40–0.82, P = 0.002).Conclusions: This novel technique for repairing frontotemporoparietal skull defects increases surgical accuracy, improves cosmetic prognosis, and reduces postoperative complications. Therefore, it is a safe and effective improvement for Ti-CP.
ESTRATEGIA METODOLÓGICA PARA DINAMIZAR LA PRÁCTICA DE AEROBIC EN ADOLESCENTES CON UN ESTILO DE VIDA SEDENTARIO
Authors: Guanoluisa Vega Gema Mercedes , Tejeda Díaz Rafael 
Published: December 2021

El presente trabajo tiene como objetivo estipular el efecto de la dinamización del aerobic en la disminución de los niveles de sedentarismo de los estudiantes en la Unidad Educativa Albertina Rivas Medina. Para descubrir los niveles del sedentarismo en los adolescentes se aplicó el test de Pérez-Rojas-García. Como resultado de este estudio, se pudo determinar que el 52% de los estudiantes se encuentran entre los rangos de sedentarismo severo y moderado y que el 48% equivale a activos y muy activos. El programa se lo llevo a cabo con una muestra, seleccionando a los estudiantes con mayor índice de sedentarismo, y luego de la intervención se pude reducir a un 35% el sedentarismo en los estudiantes. Es deber de todos y cada uno de los actores de la institución educativa, tomar medidas para mejorar los estilos de vida, y ayudar así a combatir con este hábito de vida, que cada vez está cobrando más vidas en el mundo entero. El aerobic es muy dinámico, por lo cual ofrece una amplia gama de opciones para ser aplicada, y estas deben de incorporarse a medida que va mejorando el rendimiento de los estudiantes.
PALABRAS CLAVE: Estrategia; metodología; aerobic; adolescentes; sedentarismo.
METHODOLOGICAL STRATEGY TO IMPROVE THE AEROBIC PRACTICE IN ADOLESCENTS WITH A SEDENTARY LIFESTYLE
ABSTRACT
The present work has as objective to stipulate the effect of the aerobic dynamization in the decrease of the sedentary levels of the students in the Educational Unit Albertina Rivas Medina. To discover the levels of sedentary lifestyle in adolescents, the Pérez-Rojas-García test was applied. As a result of this study, it was determined that 52% of students are between the ranges of severe and moderate sedentary lifestyle and that 48% are active and very active. The program was carried out with a sample, selecting the students with the highest sedentary index, and after the intervention it was possible to reduce the sedentarism in the students to 35%. It is the duty of each and every one of the actors of the educational institution to take measures to improve lifestyles, and thus help combat this habit of life, which is increasingly taking more lives in the whole world. Aerobic is very dynamic, which is why it offers a wide range of options to be applied, and these should be incorporated as the performance of the students improves.
KEYWORDS: Strategy; methodology; aerobics; adolescents; sedentary lifestyle.
ENSEÑANZA DE NEUROEDUCACIÓN APLICADA A LA ADMINISTRACIÓN MEDIANTE E-LEARNING
Authors: Cueva Martha Cecilia , Romero Palacios Amparo De Jesús , Alajo Anchatuña Alexandra , Falconí Tapia Angelita , Gallardo Gallardo Germánico Javier , Salguero Barba Nelly Germania 
Published: December 2021

La evolución de las Tecnologías de la Información y la Educación, ha permitido el desarrollo de plataformas de comunicación, que ofrecen la posibilidad al estudiante, ser protagonista de su propio aprendizaje. El planteamiento se sustenta en la siguiente pregunta ¿Cuál es el grado de relación entre el conocimiento de la Neuroeducación y el desempeño docente en las instituciones educativas a nivel Universitarias teniendo en cuenta la aplicación de la nueva tecnología como lo es E-Learning?, con esta conoceremos en qué medida se relaciona el aprendizaje de los estudiantes Universitarios. Tiene como objetivo aplicar la enseñanza de la Neuroeducación en la administración a los estudiantes de la carrera de Gestión de la Información Gerencial a través de la aplicación de E-LEARNING. La metodología utilizada es la cualitativa donde utilizamos métodos teóricos y empíricos. Como resultados obtuvimos que este sistema ha transformado la educación, abriendo puertas al aprendizaje individual y organizacional.
PALABRAS CLAVES: Enseñanza; aprendizaje; Neuroeducación; aplicación E Learning.
NEUROEDUCATION TEACHING APPLIED TO ADMINISTRATION THROUGH E-LEARNING
ABSTRACT
The evolution of Information and Education Technologies has allowed the development of communication platforms, which offer students the possibility to be protagonists of their own learning. The approach is based on the following question: What is the degree of relationship between the knowledge of Neuroeducation and the teaching performance in educational institutions at the University level taking into account the application of new technology such as E-Learning? We will know to what extent the learning of University students is related. Its objective is to apply the teaching of Neuroeducation in administration to the students of the Management of Management Information career through the application of E-LEARNING. The methodology used is the qualitative one where we use theoretical and empirical methods. As results we obtained that this system has transformed education, opening doors to individual and organizational learning.
KEYWORDS: Teaching; learning; Neuroeducation; E Learning application.