bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОБОРОННИЙ КОМПЛЕКС ЛІТОПИСНОГО ЗВЕНИГОРОДА
Authors: Терський Святослав Володимирович 
Published: November 2021

Один із головних політичних центрів Галицького князівства – Звенигород, розташований поблизу галицько-волинського кордону на перетині стратегічних шляхів протягом ХІ – ХІІІ ст. відігравав важливу роль у військово-політичних подіях. На полях поряд із Звенигородом відбулося принаймні декілька великих битв за володіння Галичиною. Три битви – 1226, 1144 та 1227 рр. знайшли відображення в літописах. Однак конкретний перебіг цих подій доволі скупо відображений в писемних джерелах. В статті проаналізовано військово-топогра­фічну ситуацію на території Звенигородського князівства. Простежено роль укріплень Звенигорода на основних стратегічних шляхах, які перетиналися в цьому місці та вели до основних центрів Галицького та Волинського князівств.
Сьогодні літописний центр князівства локалізований на території одноймен­ного села біля Львова. В статті підбито підсумки багаторічних археологічних досліджень із вивчення військової інфраструктури Х–ХІІІ ст. в цьому районі. Враховано результати найновіших археологічних розвідок на території Звени­городського князівства. Проведеними роботами встановлено датування решток давніх фортець. Проаналізовано зчислені знахідки середньовічного озброєння, які додатково ілюструють стан військової інфраструктури літописного Звенигорода.
ПРЕДМЕТИ ЗБРОЇ, ЕЛЕМЕНТИ СПОРЯДЖЕННЯ ТА ОБМУНДИРУВАННЯ З ПРИВАТНОЇ ЗБІРКИ ЗИГМУНТА РОЗВАДОВСЬКОГО У МУЗЕЙНИХ КОЛЕКЦІЯХ
Authors: Прокіп Андрій Володимирович , Михальський Юрій Володимирович 
Published: November 2021

У статті розглянуто, систематизовано та подано характеристику окремих предметів зброї, елементів спорядження, військового обмундирування, що походять з приватної збірки Зигмунта Розвадовського (1870 – 1950) – художника-баталіста, сценографа, педагога, а також і колекціонера – збирача предметів старовини. Аналіз інвентарних книг колишнього Національного музею ім. короля Яна ІІІ у Львові дозволив з’ясувати, що 1935 р. музей придбав у З. Розвадовського 58 одиниць зброї (як холодної, так і вогнепальної), а також елементів військо­вого спорядження та обмундирування. Деякі з цих предметів згодом увійшли до колекції Львівського історичного музею.
Legislative regulation of publishing in Ukraine
Authors: Ulitina Olha 
Published: November 2021

Keywords: creative industries, publishing, book publishing, copyright, IP rights,copyright infringement, IP legislation
Publishing is animportant element for the development of many areas of human activity. The impactof publishing on culture, education and tourism in any country cannot be underestimated.Publishing is of great importance for the development of literature, both withinone country and in the world as a whole.Today, publishing faces many challenges, including piracy, the difficulty of distributingdigital copies of literary works and insufficient funding, along with a relativelylow interest in legal publications. However, publishing is defined in Ukraine as a creativeindustry and now the state's position on strengthening publishing as an industryin Ukraine is becoming more active. That is why the issues of legislative regulationof activities in this area, as well as its connection with intellectual propertyrights, are relevant. The creation of the list of economic activities that belong to the creative industries in Ukraine indicates the government's intention to graduallytransfer Ukraine's economy to a more modern model, where industries related to thecreative industries are of the greatest importance for the economy and the developmentof the state as a whole.The article is devoted to the issue of publishing legislative regulation in Ukraine.The author analyses the most important laws in this area, considering publishing primarilyas a creative industry. The state policy in this sphere is considered, which isdirected first on development of publishing and on support of publishing the Ukrainian-language editions.The author points out the existence of certain differences in the legislative regulationof book publishing and publishing of the periodicals in Ukraine.The article considers the data of the Ukrainian Book Institute on the current stateof publishing in Ukraine. According to these data, one of the biggest problems in thepublishing is the significant number of copyright infringements and IP rights infringementsin general.Given the high rate of copyright infringement and IP rights in general in the publishing,it is necessary to review the mechanism of influence on combating them, aswell as increase liability for such infringements.
Evaluation of Molecular Point-of-Care Testing for Respiratory Pathogens in Children With Respiratory Infections: A Retrospective Case-Control Study
Authors: Shen Nan , Zhou Yuanjie , Zhou Yajuan , Luo Lijuan , Chen Wenjuan , Wang Jing , Zhao Ruike , Xie Li , Cao Qing , Tao Yue , Mo Xi 
Published: November 2021

ObjectivesOveruse of antibiotics and antibiotic resistance are global healthcare problems. In pediatric patients with respiratory infections, viral and bacterial etiologies are challenging to distinguish, leading to irrational antibiotic use. Rapid and accurate molecular diagnostic testing methods for respiratory pathogens has been shown to facilitate effective clinical decision-making and guide antibiotic stewardship interventions in the developed regions, but its impacts on pediatric patient care in the developing countries remain unclear.MethodsIn this single-center, retrospective case-control study, we compared demographics, clinical characteristics, especially microbiological findings, and antibiotic usage between pediatric patients with respiratory infection receiving FilmArray Respiratory Panel (FilmArray RP) testing and a matched routine testing control group. Our primary outcome was the duration of intravenous antibiotics treatment (DOT) during hospitalization.ResultsEach group consisted of 346 children with a respiratory infection. In the FilmArray RP testing group, the DOT was shorter than that in the routine testing group (6.41 ± 3.67 days versus 7.23 ± 4.27 days; p = 0.006). More patients in the FilmArray RP testing group de-escalated antibiotic treatments within 72 hours of hospitalization (7.80%, 27/346 versus 2.60%, 9/346; p = 0.002). By contrast, fewer patients in the FilmArray RP testing group had escalated antibiotic treatments between 72 hours and seven days (7.80% versus 14.16%; p = 0.007). The cost of hospitalization was significantly lower in the FilmArray RP testing group ($ 1413.51 ± 1438.01 versus $ 1759.37 ± 1929.22; p = 0.008). Notably, the subgroup analyses revealed that the FilmArray RP test could shorten the DOT, improve early de-escalation of intravenous antibiotics within 72 hours of hospitalization, decline the escalation of intravenous antibiotics between 72 hours and seven days, and reduce the cost of hospitalization for both patient populations with or without underlying diseases.ConclusionsMolecular point-of-care testing for respiratory pathogens could help to reduce intravenous antibiotic use and health care costs of pediatric patients with respiratory infections in developing countries.
Alendronate Use and Risk of Type 2 Diabetes: A Nationwide Danish Nested Case-Control Study
Authors: Viggers Rikke , Al-Mashhadi Zheer , Starup-Linde Jakob , Vestergaard Peter 
Published: November 2021

ObjectiveA link has been proposed between glucose homeostasis and bone metabolism. Bisphosphonates are first-line treatment of osteoporosis, and we aimed to investigate whether the risk of developing type 2 diabetes was associated with prior use of alendronate.Research Design and MethodsWe conducted a population-based nested case-control study through access to all discharge diagnoses (ICD-10 system) from the National Danish Patient Registry along with all redeemed drug prescriptions (ATC classification system) from the Health Service Prescription Registry. All cases with a diagnosis of type 2 diabetes between 2008 and 2018 were matched on sex and age with 3 randomly selected controls by incidence-density sampling. Exposure was defined as ever use of alendronate and further grouped as effective and compliant use. ORs were calculated by conditional logistic regression analysis with adjustment for several confounders and test for trend for dose-response relationship.ResultsWe included 163,588 patients with type 2 diabetes and 490,764 matched control subjects with a mean age of 67 years and 55% male subjects. The odds of developing type 2 diabetes were lower among ever users of alendronate (multiple adjusted OR: 0.64 [95% CI 0.62-0.66]). A test for trend suggested a dose-response relationship between longer effective use of alendronate and lower risk of type 2 diabetes.ConclusionThese results suggest a possible protective effect of alendronate in a dose-dependent manner against development of type 2 diabetes.
Case Report: Identification of Germline Chimerism in Monochorionic Dizygotic Twins
Authors: Chen Juan , Xu Jian , Chen Zhi-Heng , Yin Min-Na , Guo Xin-Yu , Sun Ling 
Published: November 2021

Monochorionic twins are generally considered to be monozygotic, as monochorionic dizygotic (MCDZ) twins are extremely rare in natural pregnancies. Several studies have reported this rare occurrence, and most of these pregnancies have been conceived by assisted reproductive technology (ART). These reports mostly focused on MCDZ twin pregnancies and the childhood development of the twins; a follow-up into adulthood and the effect on their reproduction has not been reported. In this case study, we report a case of chimerism in opposite-sex MCDZ twins who were naturally conceived and have reached reproductive maturity. We collected oral mucosal, endometrial, and germ cells from the twins and evaluated their chimerism using single-nucleotide polymorphism (SNP) array and droplet digital PCR (ddPCR). The SNP array showed that they had 4,049 non-allele shared loci, and they inherited nearly 50% informative SNP loci from each parent, confirming that they are dizygotic twins. We found that the female twin had a 46, XX (2)/46, XY (78) karyotype in her peripheral blood. The SNP array confirmed that the female twin and male twin had the same blood haplotype. The ddPCR result showed 92.84 (± 1.80%) chimerism in her blood. In case of chimerism in her germline, the female twin chose preimplantation genetic testing for aneuploidy for her blastocysts. Fortunately, the patient only had blood chimerism. A healthy boy was born at 39 weeks of gestation.
TMPRSS3 Gene Variants With Implications for Auditory Treatment and Counseling
Authors: Moon In Seok , Grant Andrew R. , Sagi Varun , Rehm Heidi L. , Stankovic Konstantina M. 
Published: November 2021

Objective: To identify and report novel variants in the TMPRSS3 gene and their clinical manifestations related to hearing loss as well as intervention outcomes. This information will be helpful for genetic counseling and treatment planning for these patients.Methods: Literature review of previously reported TMPRSS3 variants was conducted. Reported variants and associated clinical information was compiled. Additionally, cohort data from 18 patients, and their families, with a positive result for TMPRSS3-associated hearing loss were analyzed. Genetic testing included sequencing and copy number variation (CNV) analysis of TMPRSS3 and the Laboratory for Molecular Medicine’s OtoGenome-v1, -v2, or -v3 panels. Clinical data regarding patient hearing rehabilitation was interpreted along with their genetic testing results and in the context of previously reported cochlear implant outcomes in individuals with TMPRSS3 variants.Results: There have been 87 previously reported TMPRSS3 variants associated with non-syndromic hearing loss in more than 20 ancestral groups worldwide. Here we report occurrences of known variants as well as one novel variant: deletion of Exons 1–5 and 13 identified from our cohort of 18 patients. The hearing impairment in many of these families was consistent with that of previously reported patients with TMPRSS3 variants (i.e., typical down-sloping audiogram). Four patients from our cohort underwent cochlear implantation.Conclusion: Bi-allelic variants of TMPRSS3 are associated with down-sloping hearing loss regardless of ancestry. The outcome following cochlear implantation in patients with variants of TMPRSS3 is excellent. Therefore, cochlear implantation is strongly recommended for hearing rehabilitation in these patients.
Reutilization of Recycled Cellulose Diacetate From Discarded Cigarette Filters in Production of Stone Mastic Asphalt Mixtures
Authors: Liu Huachen , Chen Yikun , Xue Yongjie 
Published: November 2021

In this paper, recycled cellulose diacetate (rCDA) derived from cigarette butts was used as a fiber stabilizer to develop stone mastic asphalt (SMA) mixtures. The characterizations of rCDA were investigated by scanning electron microcopy (SEM), a Fourier transform infrared spectrometer (FTIR), and a thermogravimetric analyzer (TGA). Volumetric stability, temperature stability, moisture stability, and fatigue performance of SMA mixtures with rCDA were tested to obtain the pavement performance. Results showed that rCDA appeared to have a tough surface texture with a curly and corrugated structure, which facilitated the enhancement of the cohesion bond with the asphalt binder. TG-DTG indicated that the maximum weight loss (62.48%) obtained at temperatures ranging from 294.1°C to 376.0°C was due to decomposition and degradation of organic matters. When 0.4% rCDA was used in the asphalt mixture, the dynamic stability was 4,105 cycles/mm. The ultimate flexural strength and flexural stiffness modulus were 3,722 MPa and 9.7 MPa. It indicated that the temperature stability of 0.4% rCDA was superior to 0.3% polyacrylonitrile fiber (PAN), while inferior to 0.3% polyester (PET). The value of tensile strength ratio and residual Marshall stability were 80.2 and 75.3%, respectively. The fatigue life of 0.4% rCDA was technically like that of 0.3% PAN and 0.3% PET at lower stress levels. All results concluded that the optimum content of rCDA in asphalt mixtures was 0.4% by mass of the binder.
Extracorporeal Cytokine Removal in Critically Ill COVID-19 Patients: A Case Series
Authors: Virág Marcell , Rottler Máté , Ocskay Klementina , Leiner Tamás , Horváth Balázs , Blanco Daniel Adam , Vasquez Alexa , Bucsi László , Sárkány Ágnes , Molnár Zsolt 
Published: November 2021

Introduction: Extracorporeal hemoadsorption (HA) is a potential adjunctive therapy in severe cases of COVID-19 associated pneumonia. In this retrospective study we report data from critically ill patients treated with HA during the first and second wave of the pandemic.Patients and Methods: All patients, who received HA therapy with CytoSorb within the first 96 h of intensive care unit (ICU) admission without hospital-acquired bacterial superinfection, were included. Clinical and laboratory data were collected: on admission, before (TB) and after (TA) HA therapy.Results: Out of the 367 COVID-19 cases, 13 patients were treated with CytoSorb, also requiring mechanical ventilation and renal replacement therapy. All patients were alive at the end of HA, but only 3 survived hospital stay. From TB-TA there was a tendency of decreasing norepinephrine requirement: 193.7 [IQR: 34.8–270.4] to 50.2 [6.5–243.5] ug/kg/day and increasing PaO2/FiO2 ratio 127.8 (95% CI: 96.0–159.6) to 155.0 (115.3–194.6) mmHg but they did not reach statistical significance (p = 0.14 and 0.58, respectively). Treatment related adverse events were not reported.Conclusion: The treatment was well-tolerated, and there was a tendency toward an improvement in vasopressor need and oxygenation during the course of HA. These observations render the need for prospective randomized trials.
Delayed Respiratory Insufficiency and Extramuscular Abnormalities in Selenoprotein N-Related Myopathies
Authors: Zhang Shu , Lei Lin , Fan Zhirong , Su Shengyao , Duo Jianying , Luan Qinrong , Lu Yan , Di Li , Wang Min , Da Yuwei 
Published: November 2021

Background: Selenoprotein N-related myopathies (SEPN1-RMs) are a subset of congenital myopathies caused by mutations of Selenoprotein N gene (SELENON or SEPN1). Clinical phenotype is considered as highly consistent and little attention has been given to the extramuscular abnormalities.Methods: We reported clinical, histopathological, and genetic features of four Chinese patients with SEPN1-RM and performed literature review on delayed respiratory insufficiency and extramuscular involvement.Results: A total of four patients exhibited both the typical and atypical clinical features of SEPN1-RM. The classical manifestations included axial and limb girdle weakness, spinal rigidity, scoliosis, respiratory insufficiency, and multiminicore morphological lesions. However, high interindividual variability was noticed on disease severity, especially the onset of respiratory involvement. Two adult patients postponed respiratory insufficiency to the third decade of life, while two juvenile patients manifested early hypoventilation with puberty exacerbation. As atypical features, extramuscular involvement of weight gain, subcutaneous adipose tissue accumulation, intellectual disability, and mild cardiac changes were observed. Molecular findings revealed three novel mutations of SELENON such as c.1286_1288 del CCT, c.1078_1086dupGGCTACATA, and c.785 G&gt;C. Ten cases with delayed respiratory insufficiency were identified from previous publications. A total of 18 studies described extramuscular abnormalities including joint contractures, alterations of body mass index (BMI), mild cardiac changes, and insulin resistance. Intellectual impairment was extremely rare.Conclusion: SEPN1-RM should be considered as a differential diagnosis in adult patients with delayed respiratory involvement. Extramuscular involvement such as body composition alterations deserves more clinical attention. The novel mutations of SELENON widened the genetic spectrum of patients with SEPN1-RM.
Minimal Access (Endoscopic and Robotic) Breast Surgery in the Surgical Treatment of Early Breast Cancer—Trend and Clinical Outcome From a Single-Surgeon Experience Over 10 Years
Authors: Lai Hung-Wen , Chen Shou-Tung , Lin Ying-Jen , Lin Shih-Lung , Lin Ching-Min , Chen Dar-Ren , Kuo Shou-Jen 
Published: November 2021

ObjectiveEndoscopic assisted breast surgery (EABS) or robotic assisted breast surgery (RABS) performed through minimal axillary and/or peri-areolar incisions has become the representative of minimal access breast surgery (MABS). We report the trend and clinical outcome of MABS for treatment of breast cancer.MethodsInformation on patients who underwent breast cancer operation by the principal investigator during the period of 2011 to 2020 was collected from a single institute for analysis. The clinical outcome, trend, and cost of MABS were analyzed and compared with conventional breast surgery (CBS).ResultsA total of 824 breast cancer patients operated by a single surgeon were enrolled in this study: 254 received CBS and 570 received MABS, namely, 476 EABS and 94 RABS. From 2011 to 2020, the number of MABS performed annually has shown an increasing trend. Compared with CBS, MABS such as breast conserving surgery and nipple sparing mastectomy (NSM) have effectively reduced wound scar length. Since the sequential uprise from conventional NSM (C-NSM), dual-axillary-areolar-incision two dimensional (2D) endoscopic assisted NSM (E-NSM), single-axillary-incision E-NSM, robotic assisted NSM (R-NSM), and single-port 3D E-NSM, the development of minimal access mastectomies increasingly paralleled with NSM. The operation time of various MABS decreased significantly and showed no statistical difference compared with CBS. R-NSM was associated with highest cost, followed by 3D E-NSM, E-NSM, and C-NSM. The positive surgical margin rate and local recurrence rate of MABS and CBS were not statistically different.ConclusionMABS showed comparable clinical outcome and preliminary oncologic safety as CBS and has been increasingly performed as the surgical treatment of breast cancer, especially minimal access NSM.
Downstaging Therapies for Unresectable Hepatocellular Carcinoma Prior to Hepatic Resection: A Systematic Review and Meta-Analysis
Authors: Chen Xinyu , Lai Lin , Ye Jiazhou , Li Lequn 
Published: November 2021

IntroductionHepatocellular carcinoma (HCC) is a high-grade malignant disease with unfavorable prognosis, and although surgical therapy is necessary, not all patients with HCC are suitable candidates for surgery. Downstaging as preoperative therapeutic strategy, which can convert unresectable HCC into resectable HCC, intends to increase the resection rate and improve prognosis.MethodsWe searched multiple databases updated to December 30, 2020, for studies on transcatheter arterial chemoembolization (TACE), Yttrium 90 microsphere selective internal radiation (SIR)/transcatheter radioembolization (TARE), hepatic arterial infusion (HAI), and systemic treatment as downstaging treatment before resection for patients with unresectable HCC.ResultsA total of 20 comparative and non-comparative studies were finally included in the meta-analysis. The pooled downstaging rate of hepatic resection (HR) was 14% [95% confidence interval (CI) 0.10–0.17] with significant heterogeneity (I2 = 94.51%). The chemotherapy, combination, and non-cirrhosis groups exhibit higher rates of downstaging, but these differences were not significant. For comparative studies, the overall survival (OS) rates of resection after downstaging were far better than those inpatients who received locoregional therapy (LRT) or systemic treatment alone at 1 year (RR 1.87, 95% CI 1.48–2.38), 3 years (RR 5.56, 95% CI 2.55–12.10), and 5 years (RR 5.47, 95% CI 2.22–13.49). In addition, the pooled disease-free survival (DFS) rates in patients undergoing HR after successful downstaging were 78% (95% CI 0.62–0.93) at 1 year, 47% (95% CI 0.25–0.68) at 3 years, and 46% (95% CI 0.32–0.59) at 5 years. The pooled OS rates were 88% (95% CI 0.82–0.95) at 1 year, 64% (95% CI 0.59–0.69) at 3 years, and 42% (95% CI 0.29–0.54) at 5 years.ConclusionsDownstaging may serve as a screening tool to identify patients who might benefit from surgery. Resection after successful downstaging can improve prognosis.