bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beta and phylogenetic diversities tell complementary stories about ecological networks biogeography
Authors: Higino Gracielle T. , Poisot Timothée 
Published: March 2021

AbstractThe beta-diversity of interactions between communities does not necessarily correspond to the differences related to their species composition because interactions show greater variability than species co-occurrence. Additionally, the structure of species interaction networks can itself vary over spatial gradients, thereby adding constraints on the dissimilarity of communities in space. We used published data on the parasitism interaction between fleas and small mammals in 51 regions of the Palearctic to investigate how beta-diversity of networks and phylogenetic diversity are related. The networks could be separated in groups based on the metrics that best described the differences between them, and these groups were also geographically structured. We also found that each network beta-diversity index relates in a particular way with phylogenetically community dissimilarity, reinforcing that some of these indexes have a strong phylogenetic component. Our results clarify important aspects of the biogeography of hosts and parasites communities in Eurasia, while suggesting that networks beta-diversity and phylogenetic dissimilarity interact with the environment in different ways.
Does grandparental child-care provision affect number, satisfaction and with whom leisure activities are done?
Authors: Ates Merih , Bordone Valeria , Arpino Bruno 
Published: March 2021

AbstractThis study investigates the impact of non-intensive and intensive supplementary grandparental child care on grandparents’ involvement in leisure activities. Three aspects of leisure activities are investigated: the number/frequency of activities, with whom they are carried out and the subjective satisfaction with them. Beside the possibility of a cumulation effect, the literature suggests that providing grandparental child care might compete with other activities, especially for women. Thus, we consider role enhancement and role strain theories to derive our hypotheses. We use longitudinal data from the German Ageing Survey (DEAS) which contains rich information on the leisure activities of people aged 40 and older. To account for selection into the provision of grandparental child care, we use a within-unit estimation approach (fixed-effects panel models). Our results show that both grandfathers and grandmothers tend to engage in more leisure activities when they provide grandparental child care. While care-giving grandfathers become more likely to engage in activities with family members without changing their engagement outside the family, we found no effect for women in this respect. Nevertheless, grandparental child-care provision modifies satisfaction with leisure activities only for women, reducing it, independently from with whom leisure activities are carried out. These findings suggest that a higher quantity of leisure activities does not necessarily imply higher quality.
Re-conceptualizing the role(s) of science in biodiversity conservation
Authors: Evans Megan C 
Published: March 2021

SummaryScience, as both a body of knowledge and a process of acquiring new knowledge, is widely regarded as playing a central role in biodiversity conservation. Science undoubtedly enhances our understanding of the drivers of biodiversity loss and assists in the formulation of practical and policy responses, but it has not yet proved sufficiently influential to reverse global trends of biodiversity decline. This review seeks to critically examine the science of biodiversity conservation and to identify any hidden assumptions that, once interrogated and explored, may assist in improving conservation science, policy and practice. By drawing on existing reviews of the literature, this review describes the major themes of the literature and examines the historical shifts in the framing of conservation. It highlights the dominance of research philosophies that view conservation through a primarily ecological lens, changes in the goal(s) of conservation and a lack of clarity over the role(s) of science in biodiversity conservation. Finally, this review offers a simple framework to more clearly and consistently conceptualize the role(s) of science in biodiversity conservation in the future. Greater critical reflection on how conservation science might better accommodate multiple knowledges, goals and values could assist in ‘opening up’ new, legitimate pathways for biodiversity conservation.
Off-pump direct hepatic veins-to-hemiazygos vein anastomosis after primary Kawashima operation: long-term result
Authors: Kaulitz Renate , Ziemer Gerhard , Hofbeck Michael 
Published: March 2021

AbstractDirect hepatic veins-to-hemiazygos connection offers the balanced distribution of hepatic venous blood to both lungs, not requiring anticoagulation. We report a 13-year follow-up after this type of off-pump Fontan completion. Patient’s hepatic veins-to-hemiazygos confluence increased with growth to allow for unobstructed flow. This unique technique can be recommended in heterotaxy patients, if atrial hepatic venous drainage and hemiazygos vein are in close proximity.
Bovine respiratory disease treatment failure: definition and impact
Authors: Booker Calvin W. 
Published: March 2021

AbstractBovine respiratory disease (BRD) treatment failure occurs when animals receiving a treatment regimen for BRD fail to directly return to health, resulting in chronic illness and a requirement for repeated treatments, sale for salvage slaughter, euthanasia or death. BRD treatment failure has both direct and indirect impacts. Direct impacts include costs to manage chronically ill animals, including those associated with BRD relapse treatment; reduced returns from animals sent for salvage slaughter, loss of the initial investment to purchase the animal and feed and other accumulated expenses to death, and costs associated with carcass disposal. Indirect impacts include costs of infrastructure requirements, and negative effects on animal welfare and employee morale.
Improving resistance of cattle to BRD through genomics
Authors: Parker Gaddis Kristen L. 
Published: March 2021

AbstractBovine respiratory disease (BRD) is of considerable economic importance to the dairy industry, specifically among young animals. Several studies have demonstrated that BRD has a significant genetic component, with heritabilities ranging from 0.04 up to 0.22, which could be utilized to select more resistant animals. Taking advantage of available genomic data will allow more accurate genetic predictions to be made earlier in an animal's life. The availability of genomic data does not negate the necessity of quality phenotypes, in this case, records of BRD incidence. Evidence has shown that genetic selection is possible through the use of producer-recorded health information. The national dairy cooperator database currently has minimal records on respiratory problems. There is an existing pipeline for these data to flow from events recorded by producers on the farm to the national database used for genetic evaluation. Additional data could also be collected through the expansion of currently utilized termination codes and used in conjunction with the records of direct health events. Selection for animals with improved BRD resistance is possible at the national level; however, collection of additional phenotypes remains a significant hurdle.
Genes, Ideology, and Sophistication
Authors: Kalmoe Nathan P. , Johnson Martin 
Published: March 2021

AbstractTwin studies function as natural experiments that reveal political ideology’s substantial genetic roots, but how does that comport with research showing a largely nonideological public? This study integrates two important literatures and tests whether political sophistication – itself heritable – provides an “enriched environment” for genetic predispositions to actualize in political attitudes. Estimates from the Minnesota Twin Study show that sociopolitical conservatism is extraordinarily heritable (74%) for the most informed fifth of the public – much more so than population-level results (57%) – but with much lower heritability (29%) for the public’s bottom half. This heterogeneity is clearest in the Wilson–Patterson (W-P) index, with similar patterns for individual index items, an ideological constraint measure, and ideological identification. The results resolve tensions between two key fields by showing that political knowledge facilitates the expression of genetic predispositions in mass politics.
Lithospheric Structure and Flat‐Slab Subduction in the Northern Appalachians: Evidence From Rayleigh Wave Tomography
Authors: Bagherpur Mojaver Omid , Darbyshire Fiona , Dave Riddhi 
Published: March 2021

AbstractA billion years of tectonic history makes southeastern Canada and the northeastern United States an exciting area to investigate the evolution of continental lithosphere. Our study area comprises terranes with either Laurentian or Gondwanan provenance that accreted to eastern North America at different times. With the aim of resolving the isotropic velocity variations across the northern Phanerozoic Appalachians and the southeastern Proterozoic Grenville Province, we adopted a Rayleigh wave tomography technique that takes multipathing, scattering, and finite frequency effects into account. Our data sets include records of teleseismic earthquakes recorded by 71 broadband seismic stations over a 2‐year period. Our high‐resolution tomography models indicate significant (±3.5%) variations in shear wave velocity across different lithospheric domains, enabling us to discuss tectonic implications. In contrast to the Peri‐Laurentian zones, seismic signatures in the Peri‐Gondwanan domains are more complex and variable. Although systematic variations of seismic velocities across different tectonic zones are observed, we find no simple relation between the lithospheric thicknesses of different tectonic zones and their age. We interpret the lithosphere‐asthenosphere boundary in our study area, located at 70–120 km depth, with the thickest and fastest lithosphere beneath New Brunswick. We suggest that this relatively thicker lithosphere is due to a slab stacking process that occurred after flat subduction of a younger domain in the Late Silurian. Occurrence of flat subduction in the Late Silurian in the northern Appalachians is also supported by geochemical and paleomagnetic evidence.
Molecular biology of Hodgkin lymphoma
Authors: Weniger Marc A. , Küppers Ralf 
Published: March 2021

AbstractClassical Hodgkin lymphoma (cHL) is unique among lymphoid malignancies in several key biological features. (i) The Hodgkin and Reed-Sternberg (HRS) tumor cells are rare among an extensive and complex microenvironment. (ii) They derive from B cells, but have largely lost the B-cell typical gene expression program. (iii) Their specific origin appears to be pre-apoptotic germinal center (GC) B cells. (iv) They consistently develop bi- or multinucleated Reed-Sternberg cells from mononuclear Hodgkin cells. (v) They show constitutive activation of numerous signaling pathways. Recent studies have begun to uncover the basis of these specific features of cHL: HRS cells actively orchestrate their complex microenvironment and attract many distinct subsets of immune cells into the affected tissues, to support their survival and proliferation, and to create an immunosuppressive environment. Reed-Sternberg cells are generated by incomplete cytokinesis and refusion of Hodgkin cells. Epstein-Barr virus (EBV) plays a major role in the rescue of crippled GC B cells from apoptosis and hence is a main player in early steps of lymphomagenesis of EBV+cHL cases. The analysis of the landscape of genetic lesions in HRS cells so far did not reveal any highly recurrent HRS cell-specific lesions, but major roles of genetic lesions in members of the NF-κB and JAK/STAT pathways and of factors of immune evasion. It is perhaps the combination of the genetic lesions and the peculiar cellular origin of HRS cells that are disease defining. A combination of such genetic lesions and multiple cellular interactions with cells in the microenvironment causes the constitutive activation of many signaling pathways, often interacting in complex fashions. In nodular lymphocyte predominant Hodgkin lymphoma, the GC B cell-derived tumor cells have largely retained their typical GC B-cell expression program and follicular microenvironment. For IgD-positive cases, bacterial antigen triggering has recently been implicated in early stages of its pathogenesis.
Creation and control of high-dimensional multi-partite classically entangled light
Authors: Shen Yijie , Nape Isaac , Yang Xilin , Fu Xing , Gong Mali , Naidoo Darryl , Forbes Andrew 
Published: March 2021

AbstractVector beams, non-separable in spatial mode and polarisation, have emerged as enabling tools in many diverse applications, from communication to imaging. This applicability has been achieved by sophisticated laser designs controlling the spin and orbital angular momentum, but so far is restricted to only two-dimensional states. Here we demonstrate the first vectorially structured light created and fully controlled in eight dimensions, a new state-of-the-art. We externally modulate our beam to control, for the first time, the complete set of classical Greenberger–Horne–Zeilinger (GHZ) states in paraxial structured light beams, in analogy with high-dimensional multi-partite quantum entangled states, and introduce a new tomography method to verify their fidelity. Our complete theoretical framework reveals a rich parameter space for further extending the dimensionality and degrees of freedom, opening new pathways for vectorially structured light in the classical and quantum regimes.
COVID-19 in early 2021: current status and looking forward
Authors: Wang Chengdi , Wang Zhoufeng , Wang Guangyu , Lau Johnson Yiu-Nam , Zhang Kang , Li Weimin 
Published: March 2021

AbstractSince the first description of a coronavirus-related pneumonia outbreak in December 2019, the virus SARS-CoV-2 that causes the infection/disease (COVID-19) has evolved into a pandemic, and as of today, >100 million people globally in over 210 countries have been confirmed to have been infected and two million people have died of COVID-19. This brief review summarized what we have hitherto learned in the following areas: epidemiology, virology, and pathogenesis, diagnosis, use of artificial intelligence in assisting diagnosis, treatment, and vaccine development. As there are a number of parallel developments in each of these areas and some of the development and deployment were at unprecedented speed, we also provided some specific dates for certain development and milestones so that the readers can appreciate the timing of some of these critical events. Of note is the fact that there are diagnostics, antiviral drugs, and vaccines developed and approved by a regulatory within 1 year after the virus was discovered. As a number of developments were conducted in parallel, we also provided the specific dates of a number of critical events so that readers can appreciate the evolution of these research data and our understanding. The world is working together to combat this pandemic. This review also highlights the research and development directions in these areas that will evolve rapidly in the near future.
Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring
Authors: Huber Marinus , Kepesidis Kosmas V. , Voronina Liudmila , Božić Maša , Trubetskov Michael , Harbeck Nadia , Krausz Ferenc , Žigman Mihaela 
Published: March 2021

AbstractHealth state transitions are reflected in characteristic changes in the molecular composition of biofluids. Detecting these changes in parallel, across a broad spectrum of molecular species, could contribute to the detection of abnormal physiologies. Fingerprinting of biofluids by infrared vibrational spectroscopy offers that capacity. Whether its potential for health monitoring can indeed be exploited critically depends on how stable infrared molecular fingerprints (IMFs) of individuals prove to be over time. Here we report a proof-of-concept study that addresses this question. Using Fourier-transform infrared spectroscopy, we have fingerprinted blood serum and plasma samples from 31 healthy, non-symptomatic individuals, who were sampled up to 13 times over a period of 7 weeks and again after 6 months. The measurements were performed directly on liquid serum and plasma samples, yielding a time- and cost-effective workflow and a high degree of reproducibility. The resulting IMFs were found to be highly stable over clinically relevant time scales. Single measurements yielded a multiplicity of person-specific spectral markers, allowing individual molecular phenotypes to be detected and followed over time. This previously unknown temporal stability of individual biochemical fingerprints forms the basis for future applications of blood-based infrared spectral fingerprinting as a multiomics-based mode of health monitoring.
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain
Authors: Kupari Jussi , Usoskin Dmitry , Parisien Marc , Lou Daohua , Hu Yizhou , Fatt Michael , Lönnerberg Peter , Spångberg Mats , Eriksson Bengt , Barkas Nikolaos , Kharchenko Peter V. , Loré Karin , Khoury Samar , Diatchenko Luda , Ernfors Patrik 
Published: March 2021

AbstractDistinct types of dorsal root ganglion sensory neurons may have unique contributions to chronic pain. Identification of primate sensory neuron types is critical for understanding the cellular origin and heritability of chronic pain. However, molecular insights into the primate sensory neurons are missing. Here we classify non-human primate dorsal root ganglion sensory neurons based on their transcriptome and map human pain heritability to neuronal types. First, we identified cell correlates between two major datasets for mouse sensory neuron types. Machine learning exposes an overall cross-species conservation of somatosensory neurons between primate and mouse, although with differences at individual gene level, highlighting the importance of primate data for clinical translation. We map genomic loci associated with chronic pain in human onto primate sensory neuron types to identify the cellular origin of chronic pain. Genome-wide associations for chronic pain converge on two different neuronal types distributed between pain disorders that display different genetic susceptibilities, suggesting both unique and shared mechanisms between different pain conditions.
Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
Authors: Meiners Annika , Bäcker Sandra , Hadrović Inesa , Heid Christian , Beuck Christine , Ruiz-Blanco Yasser B. , Mieres-Perez Joel , Pörschke Marius , Grad Jean-Noël , Vallet Cecilia , Hoffmann Daniel , Bayer Peter , Sánchez-García Elsa , Schrader Thomas , Knauer Shirley K. 
Published: March 2021

AbstractSurvivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. This protein–protein interaction represents an attractive target in cancer research and therapy. Here, we report a sophisticated strategy addressing Survivin’s nuclear export signal (NES), the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine. These were covalently connected to small peptides resembling the natural, self-complementary dimer interface which largely overlaps with the NES. Several biochemical methods demonstrated sequence-selective NES recognition and interference with the critical receptor interaction. These data were strongly supported by molecular dynamics simulations and multiscale computational studies. Rational design of lysine tweezers equipped with a peptidic recognition element thus allowed to address a previously unapproachable protein surface area. As an experimental proof-of-principle for specific transport signal interference, this concept should be transferable to any protein epitope with a flanking well-accessible lysine.
Antarctic Peninsula warm winters influenced by Tasman Sea temperatures
Authors: Sato Kazutoshi , Inoue Jun , Simmonds Ian , Rudeva Irina 
Published: March 2021

AbstractThe Antarctic Peninsula of West Antarctica was one of the most rapidly warming regions on the Earth during the second half of the 20th century. Changes in the atmospheric circulation associated with remote tropical climate variabilities have been considered as leading drivers of the change in surface conditions in the region. However, the impacts of climate variabilities over the mid-latitudes of the Southern Hemisphere on this Antarctic warming have yet to be quantified. Here, through observation analysis and model experiments, we reveal that increases in winter sea surface temperature (SST) in the Tasman Sea modify Southern Ocean storm tracks. This, in turn, induces warming over the Antarctic Peninsula via planetary waves triggered in the Tasman Sea. We show that atmospheric response to SST warming over the Tasman Sea, even in the absence of anomalous tropical SST forcing, deepens the Amundsen Sea Low, leading to warm advection over the Antarctic Peninsula.
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment
Authors: Rubio-Perez Carlota , Planas-Rigol Ester , Trincado Juan L. , Bonfill-Teixidor Ester , Arias Alexandra , Marchese Domenica , Moutinho Catia , Serna Garazi , Pedrosa Leire , Iurlaro Raffaella , Martínez-Ricarte Francisco , Escudero Laura , Cordero Esteban , Cicuendez Marta , Ruiz Sara , Parra Genís , Nuciforo Paolo , Gonzalez Josep , Pineda Estela , Sahuquillo Juan , Tabernero Josep , Heyn Holger , Seoane Joan 
Published: March 2021

AbstractBrain metastases are the most common tumor of the brain with a dismal prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors (ICI) and the degree and phenotype of the immune cell infiltration has been used to predict response to ICI. However, the anatomical location of brain lesions limits access to tumor material to characterize the immune phenotype. Here, we characterize immune cells present in brain lesions and matched cerebrospinal fluid (CSF) using single-cell RNA sequencing combined with T cell receptor genotyping. Tumor immune infiltration and specifically CD8+ T cell infiltration can be discerned through the analysis of the CSF. Consistently, identical T cell receptor clonotypes are detected in brain lesions and CSF, confirming cell exchange between these compartments. The analysis of immune cells of the CSF can provide a non-invasive alternative to predict the response to ICI, as well as identify the T cell receptor clonotypes present in brain metastasis.