bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter and intra-annual links between climate, tree growth and NDVI: improving the resolution of drought proxies in conifer forests
Authors: Pompa-García Marín , Camarero J. Julio , Colangelo Michele , González-Cásares Marcos 
Published: July 2021

AbstractThe inter- and intra-annual variability in radial growth reflects responses to climatic variability and water shortage, especially in areas subjected to seasonal drought. However, it is unknown how this variability is related to forest productivity, which can be assessed by measuring changes in canopy greenness and cover through remote sensing products as the Normalized Difference Vegetation Index (NDVI). We combine xylogenesis with measurements of inter-annual changes in seasonal wood production (earlywood width, adjusted latewood width) and NDVI to improve the understanding of climate and drought impacts on growth and forest productivity in a Pinus teocote stand located in northern Mexico. Cambial dynamics accelerated in March and a high production of radially enlarging and thickening tracheids were observed from April to October and from June to October, respectively. Tracheid maturation was very active in October when latewood production peaked. Wet conditions in winter-spring and summer-autumn enhanced earlywood and latewood production, respectively. Earlywood and latewood were constrained by long (4–10 months) and short (2–3 months) droughts, respectively. The earlywood production depended on April soil moisture, which agrees with the peak of radially enlarging tracheid production found during that month. Aligning drought proxies at inter- and intra-annual scales by using growth and productivity measures improves our understanding of conifer forest responses to water shortage.
Universal access: user needs for immersive captioning
Authors: Hughes Chris. J. 
Published: July 2021

AbstractThis article focuses on building a prototyping for immersive captioning following a user-centric approach. This methodology is characterised by following a bottom-up approach, where usability and user needs are at the heart of the development. Recent research on user requirements for captioning in immersive environments has shown that there is both a need for improvement and a wealth of research opportunities. The final aim is to identify how to display captions for an optimal viewing experience. This work began four years ago with some partial findings. We build from the lessons learnt, focussing on the user-centric design requirements cornerstone: prototyping. Our prototype framework integrates methods used in existing solutions aiming at instant contrast-and-compare functionalities. The first part of the article presents the state of the art for user requirements identifying the reasons behind the development of the prototyping framework. The second part of the article describes the two-stage framework development. The initial framework concept answered to the challenges resulting from the previous research. As soon as the first framework was developed, it became obvious that a second improved solution was required, almost as a showcase on how ideas can quickly be implemented for user testing, and for users to elicit requirements and creative solutions. The article finishes with a list of functionalities, resulting in new caption modes, and the opportunity of becoming a comprehensive immersive captions testbed, where tools such as eye-tracking, or physiological testing devices could be testing captions across any device with a web browser.
Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish
Authors: Alzualde Ainhoa , Jaka Oihane , Latino Diogo A. R. S. , Alijevic Omar , Iturria Iñaki , de Mendoza Jorge Hurtado , Pospisil Pavel , Frentzel Stefan , Peitsch Manuel C. , Hoeng Julia , Koshibu Kyoko 
Published: July 2021

AbstractAlkaloids are a structurally complex group of natural products that have a diverse range of biological activities and significant therapeutic applications. In this study, we examined the acute, anxiolytic-like effects of nicotinic acetylcholine receptor (nAChR)-activating alkaloids with reported neuropharmacological effects but whose effects on anxiety are less well understood. Because α4β2 nAChRs can regulate anxiety, we first demonstrated the functional activities of alkaloids on these receptors in vitro. Their effects on anxiety-like behavior in zebrafish were then examined using the zebrafish novel tank test (NTT). The NTT is a relatively high-throughput behavioral paradigm that takes advantage of the natural tendency of fish to dive down when stressed or anxious. We report for the first time that cotinine, anatabine, and methylanatabine may suppress this anxiety-driven zebrafish behavior after a single 20-min treatment. Effective concentrations of these alkaloids were well above the concentrations naturally found in plants and the concentrations needed to induce anxiolytic-like effect by nicotine. These alkaloids showed good receptor interactions at the α4β2 nAChR agonist site as demonstrated by in vitro binding and in silico docking model, although somewhat weaker than that for nicotine. Minimal or no significant effect of other compounds may have been due to low bioavailability of these compounds in the brain, which is supported by the in silico prediction of blood–brain barrier permeability. Taken together, our findings indicate that nicotine, although not risk-free, is the most potent anxiolytic-like alkaloid tested in this study, and other natural alkaloids may regulate anxiety as well.
Effect of Ausforming on the Macro- and Micro-texture of Bainitic Microstructures
Authors: Eres-Castellanos Adriana , Morales-Rivas Lucia , Jimenez Jose Antonio , Caballero Francisca G. , Garcia-Mateo Carlos 
Published: July 2021

Abstract
The reason why variant selection phenomena occur in ausforming treatments is still not known. For that reason, in this work, the effect of compressive deformation on the macro and micro-texture of a bainitic microstructure was analyzed in a medium-carbon high-silicon steel subjected to ausforming treatments, where deformation was applied at 520 °C, 400 °C and 300 °C. The as-received material presented a very weak

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fiber texture along the rod axis, due to prior thermomechanical processing. For the samples isothermally heat-treated, it was detected that the bainitic ferrite inherited a

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fiber texture from the

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fiber texture present in the prior austenite. The intensity of this transformation texture was more pronounced as the deformation temperature decreased. Also, variant selection was examined at different scales by combining Electron-Backscattered Diffraction and X-ray Diffraction. The quantification of the fraction of crystallographic variants under certain conventions for every condition revealed variant selection in samples subjected to ausforming treatments, where these phenomena were stronger as the deformation temperature was lower. Finally, some of the theories proposed so far to explain these variant selection phenomena were tested, showing that variants were not selected based on their Bain group and that their selection can be better described in terms of their belonging to packets, if these are defined according to a global reference frame. This suggests that the phenomena might have to do with the effect of deformation mechanisms on the prior austenite.
Improving Diagnostic Workup Following Traumatic Spinal Cord Injury: Advances in Biomarkers
Authors: Schading Simon , Emmenegger Tim M. , Freund Patrick 
Published: July 2021

Abstract
Purpose of Review
Traumatic spinal cord injury (SCI) is a life-changing event with drastic implications for patients due to sensorimotor impairment and autonomous dysfunction. Current clinical evaluations focus on the assessment of injury level and severity using standardized neurological examinations. However, they fail to predict individual trajectories of recovery, which highlights the need for the development of advanced diagnostics. This narrative review identifies recent advances in the search of clinically relevant biomarkers in the field of SCI.

Recent Findings
Advanced neuroimaging and molecular biomarkers sensitive to the disease processes initiated by the SCI have been identified. These biomarkers range from advanced neuroimaging techniques, neurophysiological readouts, and molecular biomarkers identifying the concentrations of several proteins in blood and CSF samples. Some of these biomarkers improve current prediction models based on clinical readouts. Validation with larger patient cohorts is warranted.

Summary
Several biomarkers have been identified—ranging from imaging to molecular markers—that could serve as advanced diagnostic and hence supplement current clinical assessments.
Candida gut colonization, yeast species distribution, and biofilm production in Clostridioides difficile infected patients: a comparison between three populations in two different time periods
Authors: Brunetti Grazia , Giuliani Alessandro , Navazio Anna Sara , Paradisi Camilla , Raponi Flavia , Conti Libenzio Adrian , Raponi Giammarco 
Published: July 2021

AbstractCandida gut colonization and yeast biofilm production capacity were investigated, by means of XTT reduction assay, in Clostridioides difficile infected (CDI) patients, in non-CDI diarrheic patients, and in healthy donors in two different time periods (2013–2015 and 2018–2019 respectively). Candida gut colonization was significantly (p < 0.001) associated to C. difficile infection, and to patients infected with hypervirulent C. difficile strains bearing the tcdC deletion at nucleotide 117 (p = 0.0003). Although there was not a prevalent yeast species in CDI patients, C. albicans was the species significantly (p < 0.001) associated to both the infections sustained by the non-hypervirulent C. difficile strains and those caused by the hypervirulent strain (p = 0.001). The biofilm production by the yeasts isolated from the CDI patients and from non-CDI diarrheic patients did not differ significantly. However, a significantly (p = 0.007) higher biofilm production was observed in the Candida strains, particularly C. albicans, isolated from healthy donors compared to that of the yeasts cultured from CDI patients. Seasonal occurrence was observed in the isolation rate of CDI and non-CDI diarrheic cases (p = 0.0019), peaking in winter for CDI patients and in spring for non-CDI diarrheic patients. Furthermore, seasonality emerged in the gut colonization by Candida of CDI patients in the winter. It seems, therefore, that the reduced capacity of biofilm production by Candida strains isolated from CDI patients might have a role in the development of C. difficile infection, probably facilitating the spread of the bacteria into the gut thus amplifying their pathogenic action.
The Use of Penile Traction Devices for Peyronie's Disease: Position Statements from the European Society for Sexual Medicine
Authors: García-Gómez Borja , Aversa Antonio , Alonso-Isa Manuel , Parnham Arie , Serefoglu Ege Can , Corona Giovanni , Bettocchi Carlo , Reisman Yacov , Skrodzka Marta , Romero-Otero Javier 
Published: July 2021

Abstract

Introduction
Penile traction therapy (PTT) aims to non-surgically reduce curvature, enhance girth, and recover lost length. Available clinical practice guidelines however lack clear recommendations regarding their use.

Aim
To present a comprehensive review and recommendation regarding the available evidence to the use of PTT in Peyronie's disease (PD).

Methods
A systematic literature search was performed on Pubmed and Medline for relevant studies from all times until 2019. Studies of PTT (monotherapy and in combination) in patients with PD with any documented degree of curvature and in either the acute or chronic phase of the disease were included. Full texts not published in English language were excluded.

Main outcomes measures
Several scenarios, including preclinical data have been investigated. For each topic covered evidence was analyzed and expert opinion was stated.

Results
The paucity of high-level studies precluded any strong recommendations, however, specific statements on this topic, summarizing the ESSM position, were provided. The available data about the use of PTT in PD are still poor, and the impact of this therapy for the treatment of PD has not been clearly stablished. Available data in the clinical setting are still poor, and the impact of these devices on PD evolution has not been clearly established.

Conclusion
PTT seems to be a valid treatment option for PD, although there is not enough evidence to give any definitive recommendation in any clinical scenario. García-Gómez B, Aversa A, Alonso-Isa M et al. The Use of Penile Traction Devices for Peyronie's Disease: Position Statements from the European Society for Sexual Medicine. Sex Med 2021;9:100387.
Sexual History Taking: Perspectives on Doctor-Patient Interactions During Routine Consultations in Rural Primary Care in South Africa
Authors: Pretorius Deidré , Couper Ian , Mlambo Motlatso 
Published: July 2021

Abstract

Background
Sexual history taking for risk behavior contributes to improving health outcomes in primary care. Giving the high numbers of people living with AIDS, every patient in South Africa should be offered an HIV test, which implies that a comprehensive sexual history must be taken.

Aim
To describe the optimal consultation process, as well as associated factors and skills required to improve disclosure of sexual health issues during a clinical encounter with a doctor in primary health care settings in North West province, South Africa.

Methods
This qualitative study, based on grounded theory, involved the video-recording of 151 consultations of adult patients living primarily with hypertension and diabetes. This article reports on the 5 consultations where some form of sexual history taking was observed. Patient consultations were analyzed thematically, which entailed open coding, followed by focused and verbatim coding using MaxQDA 2018 software. Confirmability was ensured by 2 generalist doctors, a public health specialist and the study supervisors.

Main Outcome Measure
Sexual history was not taken and patients living with sexual dysfunction were missed. If patients understand how disease and medication contribute to their sexual wellbeing, this may change their perceptions of the illness and adherence patterns.

Results
Sexual history was taken in 5 (3%) out of 151 consultations. Three themes emerged from these 5 consultations. In the patient-doctor relationship theme, patients experienced paternalism and a lack of warmth and respect. The consultation context theme included the seating arrangements, ineffective use of time, and privacy challenges due to interruptions and translators. Theme 3, consultation content, dealt with poor coverage of the components of the sexual health history.

Conclusion
Overall, sexual dysfunction in patients was totally overlooked and risk for HIV was not explored, which had a negative effect on patients’ quality of life and long-term health outcomes. The study provided detailed information on the complexity of sexual history taking during a routine consultation and is relevant to primary health care in a rural setting. Pretorius D, Couper I, Mlambo M. Sexual History Taking: Perspectives on Doctor-Patient Interactions During Routine Consultations in Rural Primary Care in South Africa. Sex Med 2021;9:100389.
How Many Dates Do I Need?
Authors: Holland-Lulewicz Jacob , Ritchison Brandon T. 
Published: July 2021

AbstractAs the use of large-scale radiocarbon datasets becomes more common and applications of Bayesian chronological modeling become a standard aspect of archaeological practice, it is imperative that we grow a community of both effective users and consumers. Indeed, research proposals and publications now routinely employ Bayesian chronological modeling to estimate age ranges such as statistically informed starts, ends, and spans of archaeological phenomena. Although advances in interpretive techniques have been widely adopted, sampling strategies and determinations of appropriate sample sizes for radiocarbon data remain generally underdeveloped. As chronological models are only as robust as the information we feed into them, formal approaches to assessing the validity of model criteria and the appropriate number of radiocarbon dates deserve attention. In this article, through a series of commonly encountered scenarios, we present easy-to-follow instructions for running simulations that should be used to inform the design and construction of chronological models.
Population-based surveillance of medical tourism among US residents from 11 states and territories: Findings from the Behavioral Risk Factor Surveillance System
Authors: Stoney Rhett J. , Kozarsky Phyllis E. , Walker Allison T. , Gaines Joanna L. 
Published: July 2021

AbstractObjective:To describe medical tourism among a subset of US residents; identify possible indicators for medical tourism.Methods:The US Centers for Disease Control and Prevention collaborated with 11 states and territories to ask 6 questions about medical tourism, using the Behavioral Risk Factor Surveillance System. Data collected from January 1, 2016, through December 31, 2016, included whether respondents traveled internationally for preplanned care, travel reasons and destinations, procedures received, and occurrence and treatment of complications. A descriptive analysis of demographics, socioeconomic status and health access variables was performed, and a regression model with a log-link function and Poisson distribution was used to estimate prevalence ratios (PR) for medical tourism.Results:Of 93,492 respondents, 517 (0.55%) traveled internationally during the previous year for care. Mexico was the most common destination (41% of trips). Dentistry accounted for 55% of treatments. Complications from care received abroad were reported by 5% of medical tourists; 67% sought care upon returning to the United States. The prevalence of medical tourism was 1.32% (95% CI, 1.00–1.64). The prevalence of medical tourism was higher in Hispanics and non-whites (PR, 3.97; 95% CI, 2.48–6.32) and higher among those without current health insurance (PR, 2.70; 95% CI, 1.69–4.34).Conclusions:This is the largest collection of population-based surveillance data describing medical tourism among US residents from multiple states and territories. Understanding the demographic and socioeconomic factors associated with medical tourism can inform evidence-based recommendations for travelers and clinicians who may advise or care for these individuals before, during, or after travel.
A contingency perspective on employees' voice behavior in response to career plateau beliefs
Authors: De Clercq Dirk 
Published: July 2021

AbstractWith a conceptual basis in conservation of resources theory, this paper investigates the relationship between employees' career plateau beliefs and their voice behavior, using parallel arguments that reflect resource-conservation versus resource-acquisition logics. The career plateau beliefs–voice behavior link, whether negative or positive, might be invigorated when employees encounter adversity in the workplace, such as due to work pressures (work overload and work–family conflict) or because of how their organization makes decisions (organizational politics and organizational underperformance). Survey data from employees in the Canadian information technology sector provide empirical support for the resource-acquisition logic: career plateau beliefs enhance employees' propensity to offer ideas for organizational improvement, particularly if they suffer from excessive workloads or conflicting work–family demands, perceive organizational decision making as political, and are unhappy about their organization's performance. These novel insights point to the critical role of a stagnated career in triggering, instead of dampening, proactive voice behaviors.
De-Linking From Western Epistemologies: UsingGuanxi-Type Relationships to Attract and Retain Hotel Guests in the Middle East
Authors: Shaalan Ahmed , Eid Riyad , Tourky Marwa 
Published: July 2021

ABSTRACTRelationships are widely recognized as key to business success in the form of both informal interpersonal networks and formal organizational relationships. While Chinese personal networks (guanxi) have attracted scholars’ interest, the concept has not been fully investigated or understood in other contexts, especially the Middle East, where personal networks fulfill some of the same roles. The underlying socio-cultural formulae of the distinctive cultural dimensions that influence relationship formation in the Middle East also remain under-explored. This research therefore investigates the dimensions ofguanxi-type relationships in the Middle East and introduces a new model integrating these relationships into the existing relationship marketing framework, enabling firms to harness personal networks for organizational gain, in turn generating customer satisfaction and retention. Using empirical data from a survey of 637 hotel guests in 17 countries – drawn from a unique target population of guests introduced to Middle Eastern hotels via personal relationships – we show howguanxi-type relationships influence organizational relationships and improve satisfaction and retention. Our significant contributions to theory and practice include extending a holistic understanding ofguanxi, enhancing knowledge of its dimensions in the Middle East, and providing managers with clear evidence for a hybrid system ofguanxi-type and organizational relationships.
Bargaining outcomes and success in EU economic governance reforms
Authors: Franchino Fabio , Mariotto Camilla 
Published: July 2021

AbstractWe assess the accuracy of procedural and bargaining models in predicting the outcomes of the reforms of the economic governance of the European Union (EU) that took place between 1997 and 2013. These negotiations were characterized by high costs of failure. We confirm the accuracy and robustness of the compromise model, but a procedural model with a costly reference point performs well, indicating that misestimation of the no-agreement cost may be a reason for its commonly reported poorer accuracy. However, this model is more sensitive to measurement errors. We also show how both models contribute to understanding bargaining success and how the conditional influence of the European Parliament should not be ignored. We conclude by discussing the implications of these results for our understanding of the EU.
The Unbearable Lightness of Trust: Trade, conviviality, and the life-world of Indian export agents in Yiwu, China
Authors: Osella Filippo 
Published: July 2021

AbstractDrawing on ethnographic data collected in China, the United Arab Emirates (UAE), and India, this article explores the life-world and practices of small-scale Indian export agents based in Yiwu, China, the world centre for the export of small commodities. It shows that in a market overdetermined by fast-moving goods, short-term gains, and low margins, export agents have to steer their way between acting with extreme caution or taking risks with their clients and suppliers. These apparently contradictory dispositions or orientations are negotiated by the judicious exercise of mistrust and suspicion. The article suggests not only that mistrust is valued and cultivated as an indispensable practical resource for success in Yiwu's export trade, but that contingent relations of trust between market players emerge at the interstices of a generalized mutual mistrust, via the mobilization of practices of hospitality, commensality, and masculine conviviality. Indeed, feelings of amity and mutuality elicited by the performance of modalities of social intimacy become the affective terrain upon which divergent economic interests might be reconciled and taken forward. That is, mistrust might not lead to generalized distrust, instead a situational or contingent trust might actually emerge through the judicious exercise of mistrust.