bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caveolin-1: A Promising Therapeutic Target for Diverse Diseases
Authors: Gokani Shivani , Bhatt Lokesh Kumar 
Published: December 2021

:
The plasma membrane of eukaryotic cells contains small flask-shaped invaginations
known as caveolae that are involved in the regulation of cellular signaling. Caveolin-1 is a 21-24k-
Da protein localized in the caveolar membrane. Caveolin-1 (Cav-1) has been considered as a master
regulator among the various signaling molecules. It has been emerging as a chief protein regulating
cellular events associated with homeostasis, caveolae formation, and caveolae trafficking. In addition
to the physiological role of cav-1, it has a complex role in the progression of various diseases.
Caveolin-1 has been identified as a prognosticator in patients with cancer and has a dual role in
tumorigenesis. The expression of Cav-1 in hippocampal neurons and synapses is related to neurodegeneration,
cognitive decline, and aging. Despite the ubiquitous association of caveolin-1 in various
pathological processes, the mechanisms associated with these events are still unclear. Caveolin-
1 has a significant role in various events of the viral cycle, such as viral entry. This review will
summarize the role of cav-1 in the development of cancer, neurodegeneration, glaucoma, cardiovascular
diseases, and infectious diseases. The therapeutic perspectives involving clinical applications
of Caveolin-1 have also been discussed. The understanding of the involvement of caveolin-1 in
various diseased states provides insights into how it can be explored as a novel therapeutic target.
Love and Death in Latin Elegy
Authors: Olfman Heva 
Published: December 2021

Love and death is a common and shared human experience that many poets of the ancient world explored in their various poetic works. The elegists of Rome famously wrote love poems in which each pined for a specific mistress or lover, and in some of these poems, love and death were simultaneously prominent themes.
In this article I examine the relationship between the concepts of love and death in Propertius 4.7, Tibullus 1.3 and Ovid’s Amores 3.9. From this study it is evident that each poet, through means of their own style, depicted the ideal that love had the ability to overcome death. To support my analysis of these texts and the issues surrounding them, I refer to Papanghelis, Hinds and Maltby. While these authors consider many aspects of Proptertius’, Tibullus’ and Ovid’s works, the relationship and connection present between love and death has not been significantly considered. In order to establish each poet’s personal style I begin with a brief overview of elegiac poetry; then, an examination of each poem’s tone, word usage and thematic distinctions. I will begin the discussion with Propertius’ poems; Tibullus’ and Ovid’s poems will then be considered, first separately, and then as a pair. The concepts of love, death and those affected by the death in the poem will be analyzed. In addition, I will consider how love and death interact with each other in the poems. To further supplement the discussion, I will analyze how these three poets’ write in the same genre and about the same topics, but in different contexts and styles. This analysis leads to an understanding that each poet expressed their unique style in their poems, while maintaining a similar theme and genre, that love has the ability to overcome the unavoidable and inevitable force of death.
Métodos de fermentación del cacao nacional (theobroma cacao) y su influencia en las características físico-químicas, contenido de cadmio y perfiles sensoriales
Authors: Neira Mosquera Juan Alejandro , Revilla Escobar Karol Yannela , Aldas Morejon Jhonnatan Placido , Sánchez Llaguno Sungey Naynee 
Published: December 2021

La presente investigación es parte del “Proyecto FOCICYT PFOC 5-14-2017 UTEQ” tuvo como objetivo determinar la variabilidad de tres tipos de cacao nacional (criollo, forastero y trinitario) y el efecto de los días de fermentación (día 1, día 3, día 4, día 5) considerando tres métodos (cajones en cascada, saco de yute, fermentación controlada) y dos zonas de cultivo (Vinces y Baba), además se realizó análisis del contenido de Cd. Para la evaluación de las características físico-químicas se empleó un diseño anidados con 12 tratamientos y 3 repeticiones. En cuanto a los perfiles sensoriales se utilizó un diseño A*B*C con 18 tratamientos y 3 repeticiones. Determinando que el método fermentación controlada – Vinces con el cacao Criollo obtuvo mejores resultados en pH almendra (5.20); pH testa (5.16) y acidez titulable (0,80). Considerando los días de fermentación, los mejores resultados fueron pH almendra: 6.35; 5.01; 5.18 y 4.94 en fermentación controlada - Baba. Para pH testa: 4.15; 4.44; 4.98; 5.57 en Cajones en cascada - Vinces. Por consiguiente, acidez titulable en Fermentación controlada - Baba situó óptimos valores: 0,88; 1,51; 1.47; 0.82. De acuerdo al análisis sensorial el tratamiento Fermentación controlada + Criollo + Baba presentó mejores resultados en las categorías aroma (4), acidez (1.00), amargor (1.67), astringencia (1.00), pos gusto (3.67), calidad (8.88), resaltando los sabores: cacao, nuez, frutal, floral. El estudio de Cadmio demostró valores que no suponen ningún riesgo al consumidor en todos los tipos de cacao y sistemas de fermentación antes mencionados, siendo alrededor de < 0.01 mg/kg.
DAMPAK PANDEMI COVID-19 TERHADAP PERILAKU KONSUMSI PARIWISATA: STUDI EMPIRIS PADA WISATAWAN DOMESTIK INDONESIA
Authors: Andriani Lis , Ramelan Muji Rahmat , Fihartini Yuniarti 
Published: December 2021

Pandemi Covid-19 berdampak pada seluruh sektor ekonomi, diantaranya industri pariwisata dan pendukungnya. Pandemi mengubah pandangan masyarakat terhadap perjalanan wisata, perilaku dalam pemilihan destinasi wisata, dan penentuan keputusan pengkonsumsiannya. Sementara keberlangsungan industri pariwisata sangat bergantung pada arus wisatawan dan persepsi individu wisatawan.
Penelitian ini menganalisis sikap wisatawan terkait faktor kebersihan dan keamanan, menganalisis perilaku wisatawan dalam pengkonsumsian pariwisata, serta melihat potensi pariwisata baik saat pandemi maupun setelah pandemi Covid-19. Penelitian ini dilakukan dengan metode survei melalui kuesioner secara online terhadap 353 responden. Pengujian hipotesis dilakukan dengan teknik statistik deskriptif one sample t-test menggunakan SPSS.
Hasil analisis menunjukkan bahwa seluruh hipotesis dalam penelitian ini dapat didukung. Wisatawan menilai sangat penting menerapkan protokol kesehatan pada masa pandemi. Pandemi tidak menghentikan minat wisatawan untuk melakukan perjalanan wisata, namun wisatawan cenderung menunda rencana perjalanan ke destinasi dengan infeksi virus Covid-19 tinggi. Wisatawan menghindari destinasi yang ramai, memilih wisata kuliner dan objek wisata luar ruang yang lokasinya dekat wilayah tempat tinggal, dan menghindari perjalanan berkelompok. Objek wisata orisinal berbasis alam (ekowisata, maritim, bahari) maupun berbasis pertanian (agrowisata) yang menawarkan privasi dan customisasi dinilai memiliki potensi dikembangkan saat pandemi maupun setelah pandemi Covid-19.
Kata Kunci: Destinasi wisata, konsumsi pariwisata, perilaku wisatawan, kebersihan dan keamanan
DESAIN ALAT BANTU ERGONOMIS DI DEPO PASAR IKAN KOTA TASIKMALAYA
Authors: Eldrin Gheva Julian , Sarvia Elty 
Published: December 2021

Depo Pasar Ikan merupakan penyedia jasa pemasaran ikan, dalam pengelolaannya masih dilakukan secara manual pada proses angkut dan penurunan ikan, sehingga menimbulkan proses pengulangan yang cukup banyak. Tujuan dilakukannya penelitian ini adalah agar terciptanya proses bongkar muat yang lebih mudah dengan penggunaan alat bantu ergonomis, sehingga para pedagang lebih mudah dalam pengangkutan dan pemindahan ikan. Penelitian ini diawali dengan observasi lapangan, wawancara, pengumpulan data seperti kapasitas angkut, dan dimensi plastik kemudian menganalisis data. Dari pengolahan data dan analisis, terbukti bahwa masih ada pengulangan yang banyak pada proses penurunan maupun pengangkutan. Untuk itu, perlu adanya alat bantu berupa Trolley Lifter yang digunakan agar bongkar muat menjadi lebih mudah dan cepat.Trolley lifter ini di rancang sesuai dengan kebutuhan pengangkutan, memiliki kelebihan yaitu dapat mengurangi proses pengulangan angkut juga dapat mengurangi beban pada saat perpindahan ikan yang dilakukan oleh penjual, dan berdasarkan analisis data antropometri agar proses penggunaannya menjadi lebih mudah dan nyaman. Kata Kunci : Proses Pengulangan, Bongkar Muat, Alat Bantu, Antropometri
Dexmedetomidine prolongs the duration of action of mepivacaine on anesthesia of the palmar digital nerves of horses
Authors: Nichols Cailey L. , Doherty Thomas J. , Schumacher James , Jones Philip D. , Sun Xiaocun 
Published: December 2021

Abstract

OBJECTIVE
To determine whether palmar digital nerve (PDN) blockade in horses with a combination of dexmedetomidine and mepivacaine would block the response to mechanical force applied to the digit longer than would anesthetizing these nerves with mepivacaine alone or dexmedetomidine alone.

ANIMALS
8 mares with no signs of lameness.

PROCEDURES
In a randomized, crossover, blinded, experimental study, both PDNs of the same forelimb of each horse were anesthetized by perineural injection with either 30 mg mepivacaine alone, 250 µg of dexmedetomidine alone, or 30 mg mepivacaine combined with 250 µg of dexmedetomidine. Each horse received each treatment, and treatments were administered ≥ 2 weeks apart. The mechanical nociceptive threshold was measured at a region between the heel bulbs with the use of a digital force gauge before (baseline) and at 15-minute intervals after treatment.

RESULTS
The mean duration of sensory blockade of the digit was 2-fold longer when a combination of mepivacaine and dexmedetomidine was administered (371 minutes), compared with when mepivacaine alone was administered (186 minutes). Treatment with dexmedetomidine alone did not change the mechanical nociceptive threshold substantially from baseline and resulted in no clinical signs of sedation.

CLINICAL RELEVANCE
Results indicated that relief from digital pain provided by perineural treatment with mepivacaine for PDN blockade can be extended by adding dexmedetomidine to the injectate.
A Cross-Cultural Study of Relationships between Epistemological Beliefs and Self-Regulated Learning Strategies
Authors: Jiang Ying Hong , Wang Jia , Bonner Patricia , Yau Jenny 
Published: December 2021

Introduction. Prior research consistently provides evidence supporting potential relationships between epistemological beliefs and learning. The current study examines the relationship between epistemological beliefs, academic motivation, and self-regulated learning strategies among different ethnic groups of American adolescents.
Method. This quantitative study utilized a correlational design to examine the relationship between epistemological beliefs and self-regulated learning strategies in adolescents attending middle school. A total of 364 middle school students (6th to 8th grade) from Southern California public middle schools participated in the study. A multiple group path model was employed to analyze the student data.
Results. We found that certain knowledge, omniscient authority, and innate ability beliefs about the nature of knowledge predict positive relationships with self-efficacy and intrinsic value components of motivation. Quick learning and simple knowledge beliefs predict negative relationships with self-efficacy and intrinsic-value but positive relationship with test-anxiety. Similarly, in the aspect of self-regulatory learning strategies, those who believe in the absolute nature of knowledge and the authorities tend to use cognitive and self-regulatory learning strategies more often, while those who believe in the speed of knowledge acquisition tend to employ those strategies less.
Discussion and Conclusion. Findings from this study inform educators of the need to advance adolescents’ epistemological beliefs for each subject (e.g., science, language arts) as a method to facilitate their motivation and self-regulated learning. We recommend that future research should include assessments of the participants’ cultural orientations or the domain specificity of the epistemological beliefs, which may vary the associations of the beliefs with self-regulated learning. Additionally, future research can further investigate other potential mediators of the relationship between epistemological beliefs and self-regulatory learning.
Celebrating the Achievements of Yet Another Challenging Year
Authors: Ardern Clare L. , Cleland Joshua A. , Heiderscheit Bryan C. , Hughes Christopher , Kamper Steven J. , Silbernagel Karin 
Published: December 2021

Editor-in-Chief Clare Ardern and JOSPT's editors thank all of those who contributed to JOSPT in 2021. J Orthop Sports Phys Ther 2021;51(12):552–555. doi:10.2519/jospt.2021.0111
You Can't Replicate What You Can't See: A Call for Researchers to Share Their Data and Avoid “Fragile” Correlations
Authors: Whiteley Rod , Steventon-Lorenzen Nikolai , Maniar Nirav , Opar David 
Published: December 2021

Synopsis We suggest that a measure of a correlation's fragility is the minimum number of items that, when replaced with the group median, result in a nonsignificant correlation on reanalysis. Between January 2000 and July 2021, there were 1769 significant correlations reported in 142 papers published in this journal, and only 51 correlations (2.9%) had available data (scatter plots from which we could digitize the raw data). Twenty-six of these 51 correlations were fragile at 4 or fewer replacements. Five of the reported significant correlations were not significant when we replicated the analysis from the extracted data. J Orthop Sports Phys Ther 2021;51(12):556–558. doi:10.2519/jospt.2021.0112
Dos momentos del movimiento estudiantil en México: 1968 y 1986
Authors: Casas Cárdenas Ernesto 
Published: December 2021

En el artículo se analizan dos movimientos estudiantiles que tuvieron verificativo durante la segunda mitad del siglo XX en México, con el objetivo de identificar algunos factores estructurales que determinaron el surgimiento de ambos, así como la contribución de estos a los movimientos estudiantiles que les sucedieron en el siglo XXI. Con ese propósito se hace una revisión histórica de cada movimiento, para después identificar confluencias y diferencias entre ellos. Entre los hallazgos más significativos, cabe destacar que en los dos casos, la sociedad mexicana enfrentaba las consecuencias de la deficiente administración de lo público, de la ausencia de espacios para la reflexión pública, así como del autoritarismo gubernamental.
Libre desarrollo de la personalidad con perspectiva de derecho emergente
Authors: Villarreal Garza Cielo Aracely , Ramírez Aguilar Antonio de Jesús 
Published: December 2021

A partir del concepto que la Suprema Corte de Justicia de la Nación ha establecido en su tesis “Derecho al libre desarrollo de la personalidad. Brinda protección a un área residual de libertad que no se encuentra cubierta por las otras libertades públicas”, publicada en el Diario Oficial de la Federación en febrero de 2019, vale la pena reflexionar sobre sus alcances y preguntarnos si el libre desarrollo de la personalidad es un derecho emergente.
Para ello, precisamos qué se entiende por derechos humanos emergentes, los motivos y justificación de su surgimiento, sus alcances e implicaciones, expuestos por el Instituto de Derechos Humanos de Cataluña, impulsor de este movimiento.
Enseguida, revisamos la postura de la Suprema Corte de Justicia de la Nación acerca del derecho humano del libre desarrollo de la personalidad, que a través de su jurisprudencia gradualmente ha ido matizando. Hacemos énfasis en la sentencia que consideramos que ha reunido los distintos elementos de los que se compone este derecho, para analizarlos y dar respuesta al cuestionamiento inicial.
A campanha difamatória contra a exposição Queermuseu
Authors: Miguel Jorge Luiz , Jaremtchuk Dária Gorete 
Published: December 2021

Este artigo procura reconstituir a campanha difamatória contra a exposição Queermuseu — cartografias da diferença na arte brasileira, que levou a seu fechamento antecipado em setembro de 2017. Analisando os acontecimentos, observa-se a propagação de pânico moral em relação ao conteúdo de algumas poucas obras expostas, que serviriam como exemplos para difundir a crença de que artistas estariam ligados a uma agenda política de esquerda interessada em corromper moralmente o público, ameaçar crianças e ofender a fé cristã. Pelo poder de manipulação e de influência sobre setores da sociedade, esse caso de censura tornou-se um capítulo significativo da história das chamadas “guerras culturais” no Brasil.
Palavras chave: Queermuseu, guerras culturais, censura às artes visuais
Entrevista com Victor Ximenes Marques –
Authors: Teixeira Vieira de Melo Cristina , Vaz Paulo 
Published: December 2021

Na entrevista que segue, realizada por Cristina Teixeira Vieira de Melo e Paulo Vaz, o pesquisador Victor Ximenes Marques, professor da Universidade Federal do ABC, fala sobre a relação das guerras culturais com a al right, o olavismo e o tradicionalismo. Victor Marques faz uma acurada reflexão sobre a forma que os diferentes posicionamentos discursos em torno das guerras culturais foram se constituindo. Trata-se da visão de alguém que acompanha essa história de perto
Hydro-environmental Characteristics of Seawater around Boubyan Island, Kuwait Using Annual Variations of Seawater Temperature, Salinity and Tide Fluctuations
Authors: Subramaniam Neelamani , Al-Osairi Yousef 
Published: December 2021

The temporal and spatial variations of seawater temperature, salinity, and tidal fluctuations are important parameters for understanding the hydrodynamic, water quality, and marine biological activity in the seawater. It is also important to study and understand the probability and statistical aspects of these parameters for the planning and implementation of different types of marine projects. These parameters were measured at five different locations around Boubyan Island, Kuwait, for a span of almost one year during 2015-16. Based on the analysis of the measured data, it is found that the seawater salinity has varied from 34.14 to 48.31 ppt. The seawater temperature is also found to vary from 10.83 oC to 35.67 oC. The seawater level has varied from -2.694 m to 2.378 m with respect to the mean sea level. It is found that the peak of the probability density of seawater level is flat valued, whereas the probability density of salinity and seawater temperature is multimodal. A comparison of present and past measured seawater temperatures revealed that in Khor Al-Sabiya, the seawater temperature is increasing at the rate of 0.034 oC/year, which clearly indicates the effect of global warming. A similar study reveals that the annual average increase in salinity at Khor Al-Sabiya is 0.38 ppt, which clearly indicates a significant reduction of freshwater flow from Shatt Al-Arab into the Arabian Gulf. Since Kuwait is investing in many projects around the Boubyan Island, the results of this study will be useful for the integrated and sustainable development of Boubyan and Failaka Islands in Kuwait.
Evaluation and Research Analysis of Marine Ecological Suitability
Authors: Liu Hongdan , Jin Xinfei , Wu Weifei , Shen Chen 
Published: December 2021

Whether in the past, present and future, marine ecological environment is the most important part in the history of human development, we can call it the "patron saint" of mankind. It provides all kinds of resources and energy needed for social production, and plays an irreplaceable role in species diversity and ecological balance. However, the weakening of self-purification ability of marine ecosystem, the decline of pollution purification ability, the deterioration of marine ecological environment, and the decline of biological resources and biodiversity ,etc. all these bring fatal impact to coastal areas and even the whole terrestrial ecosystem, it is imminent to strengthen ecological protection. It is our bounden duty to protect the living environment of human. We have the right to enjoy the convenience brought by the natural environment, so we should fulfill the obligation to protect it.[Chinese Library Classification Number] X31 [Document Code] A
(MOLDING DESIGN OF PADANG STATE POLYTECHNIC LOGO SOUVENIR MOLDING ON PRESSED PLASTIC INJECTION MOLDING MACHINE 1,960 KG / CM²)
Authors: Alfian Alfian 
Published: December 2021

ABSTRACT
Padang State Polytechnic has been established since 1987 under the name Polytechnic Engineering and then changed its name several times to the management policy by Andalas University then, until now it is independent until now with the name Padang State Polytechnic. The 33-year-old polytechnic of the Padang State Polytechnic establishment must have an icon, symbol and trinkets that have PNP characteristics so that they are easy to recognize and remember. Souvenirs are a form of applying media for promotion and souvenirs for people who already know and come to Padang State Polytechnic.
Plastic injection molding machine is a machine used to mold plastics with a basic material in the form of plastic pellets. Plastic injection molding machine is the process of processing plastic material in the form of seeds which are heated until they become liquid and then injected into the molding which then freezes / hardens according to the shape of the mold. The products produced by injection molding machines vary, from electronic tools, automotive tools, home appliances, plastic souvenirs, to tableware. The success of the resulting product is highly dependent on Molding. The plastic injection molding machine has parts, namely the Injection Unit, Molding Unit and Clamping Unit. The Injection Unit and Clamping Unit are the most important parts in the manufacturing process of plastic products where the control operation is executed on the control panel found on the plastic injection molding machine. The control panel on the machine can adjust the amount of clamping pressure, stroke length, plastic volume, and temperature used.
The molding unit is the main part of the plastic product manufacturing process. Mold (mold) is a tool / tool used to make products according to the desired design (shape and dimensions). Plastic molding has its respective functions, parts of the mold, namely Cavity and Core, Sprue, Runner and Gate, Undercut. The printing process on a Plastic Molding machine has several stages such as the cutting process, mold safety and machine safety, execution, product check, setting, execution, and final. Materials used in the Plastic Molding process are usually materials that are often used daily and are safe for use by all groups, such as Polyproplene, Polycarbonate, and High Density Poly Ethylene. The product that will be produced from the molding made is a key toy souvenir made of plastic, with a shape like the Padang State Polytechnic logo, measuring 6 cm long, 6 cm wide and 5 mm thick.
The test results obtained will be shown through field applications, socialization at the Padang State Polytechnic and writing in national journals are the targets and outputs of this novice lecturer research activity.

Keywords— Mold, Souvenir, Cavity, Core, Pnp.