bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phát triển thuật toán chó rừng vằn hông để tối ưu hóa quá trình vận chuyển và giảm ô nhiễm khí thải CO2 trong công nghiệp và dân dụng
Authors: Sơn Phạm Vũ Hồng , Khôi Trần Trọng 
Published: May 2021

Quá trình điều phối hoạt động cung cấp hàng hóa để đạt yêu cầu và hiệu quả là một yêu cầu khó trong quản lý chuỗi cung ứng. Những sự thay đổi liên tục trong quá trình vận chuyển và yêu cầu cao về lượng khí thải ra môi trường là những thách thức không nhỏ cho các nhà phân phối. Nghiên cứu phát triển một thuật toán mới, lấy cảm hứng từ quá trình săn mồi của loài chó rừng vằn hông (Side-striped jackal) để tạo ra thuật toán tìm kiếm hiệu quả hơn so với các thuật toán cũ. Nghiên cứu sử dụng dụng mô phỏng sự kiện rời rạc (DES) và đưa ra các sự cố giả định để giải quyết bài toán tối ưu hóa đa mục tiêu với kì vọng chọn được phương án có tổng thời gian chờ và quãng đường di chuyển là tối ưu nhất. Kết quả được so sánh với các thuật toán cũ cho thấy tính nổi trội của thuật toán đề xuất khi đưa ra được các phương án kinh tế hơn và ít khí thải khí CO2 ra môi trường hơn. Nghiên cứu còn giải quyết được vấn đề thay đổi lộ trình đi khi xét đến các điều kiện thực tế. Qua đó, thuật toán mới giúp cho quá trình quản lý vận chuyển hàng hóa chủ động hơn và giảm thiểu phát sinh chi phí khi có những điều kiện bất lợi không mong muốn xảy ra.
Từ khóa:
tối ưu hóa chó rừng vằn hông; SSJ; hiệu ứng nhà kính; tối ưu hóa quá trình vận chuyển; thuật toán tối ưu bầy đàn.
Partisipasi Aktor dalam Penanganan Abrasi melalui Pembangunan Kawasan Wisata Pesisir Pantai Plentong
Authors: Nurkhotija Ghea , Nugraha Okky Kusuma , Patria Andika Nur 
Published: May 2021

Kabupaten Indramayu merupakan daerah yang memiliki bentang alam pesisir yang cukup luas, dengan total panjang bibir pantai mencapai 174 km wilayah ini memiliki potensi sebagai daerah wisata apabila dikelola lebih lanjut. Permasalahan yang sering terjadi di wilayah pesisir adanya abrasi pantai yang mengeruk luas dataran di suatu wilayah. Penerapan kawasan ekowisata merupakan salah satu solusi dari permasalahan abrasi di sebuah wilayah, dengan menyeimbangkan antara konservasi alam dan pariwisata diharapkan dapat menarik lebih banyak partisipasi masyarakat dan aktor-aktor yang berpengaruh. Berdasarkan hal tersebut penelitian ini bertujuan untuk mengidentifikasi aktor-aktor yang berpartisipasi dalam pengembangan kawasan wisata pantai plentong sebagai bentuk pengentasan permasalahan abrasi di wilayah tersebut. Pendekatan penelitian yang digunakan dalam penelitian ini merupakan pendekatan kualitatif melalui metode deskriptif. Pada akhirnya pendekatan yang diterapkan di pantai Plentong diharapkan dapat di replikasi di wilayah lainnya sebagai salah satu solusi pengembangan wilayah pesisir.
Effectiveness Of Prenatal Yoga On The Level Of Anxiety And Long-Time Labor On Maternity Primiparous
Authors: Fatmayanti Aulia , Isharyanti Septalia , Widyastuti Erna 
Published: May 2021

The process of delivering on each mother must be different. Apparently, in addition to be the cause of the clinical, psychological atmosphere of the mother who does not support also contribute to complicate the process ofchildbirth. As a mother in a state of anxiety, excessive worry and fear, until eventually lead to stress. The purpose of the research was to determine the effectiveness of prenatal yoga on anxiety level and the second stage of labor longer on maternity primiparous. Methods research with quantitative approachquasi experimental with control grou pdesign. The total sample of 20 respondents, each group of 10 respondents. Bivariate analysis is done in two variables: the old stage II with categorical scale so usingtest. chi-square Jikasyaratchi-squareis not met using the Fisher exactprovided that if the value sig(p)0.05 then say no relationship signifikan.dan anxiety level has a categorical scale, if it does not qualifytest chi-square then used thealternative test Kolmogorov- Smirnov. The results of the study was prenatal yoga is proven effective against anxiety levels in maternal primipara withvalue significancy 0,003and prenatal yoga are effective against the second stage of labor longer on maternity primipara withvalue of significancy 0.003. Prenatal yoga is proven effective against anxiety levels in maternal and prenatal yoga primiparous effective against second stage of labor longer in primiparous birthmothers.
Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats
Authors: Gan Li , Wan Xiaonan , Ma Delin , Yang Fu-Chen , Zhu Jingpeng , Rogers Robert S. , Wheatley Joshua L. , Koch Lauren G. , Britton Steven L. , Thyfault John P. , Geiger Paige C. , Stanford John A. 
Published: May 2021

Background: Aerobic capacity is associated with metabolic, cardiovascular, and neurological health. Low-capacity runner (LCR) rats display low aerobic capacity, metabolic dysfuction, and spatial memory deficits. A heat treatment (HT) can improve metabolic dysfunction in LCR peripheral organs after high fat diet (HFD). Little is known about metabolic changes in the brains of these rats following HT. Objective: Our objective was to examine the extent to which high or low aerobic capacity impacts Akt (a protein marker of metabolism) and heat shock protein 72 (HSP72, a marker of heat shock response) after HFD and HT in hippocampus. Methods: We measured phosphorylated Akt (pAkt) in the striatum and hippocampus, and HSP72 in the hippocampus, of HFD-fed and chow-fed LCR and high-capacity runner (HCR) rats with and without HT. Results: pAkt was lower in the hippocampus of chow-fed LCR than HCR rats. HFD resulted in greater pAkt in LCR but not HCR rats, but HT resulted in lower pAkt in the LCR HFD group. HSP72 was greater in both HCR and LCR rat hippocampus after HT. The HFD blunted this effect in LCR compared to HCR hippocampus. Conclusion: The abnormal phosphorylation of Akt and diminished HSP response in the hippocampus of young adult LCR rats might indicate early vulnerability to metabolic challenges in this key brain region associated with learning and memory.
Increased aldehyde dehydrogenase 1 (ALDH1) levels are associated with chemo-responsiveness in breast cancer patients treated with taxane–adriamycin–cyclophosphamide regimen
Authors: Hapidah Hapidah , Djabir Yulia Yusrini , Prihantono Prihantono 
Published: May 2021

BACKGROUND: Increased plasma aldehyde dehydrogenase 1 (ALDH1) levels have been proposed to predict cancer chemoresistance. However, studies have reported inconsistent results, depending on the type of cancer cells used. OBJECTIVE: This study aimed to investigate the correlation between plasma levels of ALDH1 and chemotherapy responses to the taxane–adriamycin–cyclophosphamide (TAC) regimen in breast cancer patients. METHODS: Thirty breast cancer patients who underwent chemotherapy using the TAC regimen were included in this study. Blood sampling was performed before chemotherapy was initiated and after the first and third cycles of chemotherapy administration. After 3 cycles of chemotherapy, patients were categorized as non-responsive if the tumor size was reduced <30%, if the tumor size remained the same or increased, or if any new tumors were discovered. Patients were defined as responsive after 3 cycles of chemotherapy if the tumor mass disappeared, if the tumor size was reduced by at least 30% of the initial size and if no new tumors were found. RESULTS: Among the 30 patients, only five were responsive to the TAC regimen. The clinical response to TAC was not correlated with the patient’s age, cancer grading, or tumor stage. A change in the ALDH1 levels was observed after the third cycle of TAC administration, with significantly higher ALDH1 levels observed in responsive compared with non-responsive patients (p < 0.05). CONCLUSION: The results of this study may indicate a role for ALDH1 in chemoresponsiveness, rather than chemoresistance, for the TAC regimen in breast cancer patients. Further research remains necessary to confirm this result.
Relationship between body mass index and cholesterol levels with histopathological grading of breast cancer
Authors: Padang Okto Sampe , Septiman Septiman , Prihantono Prihantono , Soraya Gita Vita , Pieter Junior John , Syamsu Salman Ardy , Sampepajung Elridho , Faruk Muhammad 
Published: May 2021

BACKGROUND: Breast cancer, a global health problem with a high mortality rate, has several risk factors, including obesity and increased lipid profile. Postmenopausal obesity is associated with estrogen production from adipose tissue, while abnormal cell growth is triggered by insulin-like growth factor 1 (IGF-1) and insulin. Obesity could be assessed by measuring body mass index (BMI). An increase in lipid profile signifies an increased risk for breast cancer. Histopathological findings in the form of grading and differentiation can indicate how serious the condition is. Breast cancer with good differentiation is always associated with a positive prognosis. OBJECTIVE: This observational analytic study aims to determine the relationship between BMI and cholesterol levels based on the menopausal status and the histopathological grading findings of breast cancer patients. METHODS: The observational cross-sectional study analyzed histopathological grading, total cholesterol level, and body mass index. Data were analyzed with Spearman rank correlation statistical test, and the results are significant when the p-value is <0.05. RESULTS: Analyzing the relationship between cholesterol levels and histopathological gradings indicated a moderate correlation. The results of another correlation test based on menopausal status showed a weak correlation value, while menopause was said to be significant, indicating a moderate correlation. However, results from the analysis of BMI data in the menopausal subject group were associated with histopathological assessment. CONCLUSIONS: There is a relationship between cholesterol levels and histopathological degrees in the two menopausal status groups. However, no relationship was found between BMI and the histopathological grades of breast cancer.
The relationship of self-acceptance with decision making duration in cancer patient to perform mastectomy
Authors: Setiawan Ayu Ratuati , Tunjungsari Feny , Sander Mochamad Aleq 
Published: May 2021

BACKGROUND: Cancer is a disease caused by abnormal growth of body cells that turn malignant and continue to grow uncontrollably. One of the treatments for breast cancer is mastectomy. The quickness of decision-making determines the survival rate of prognosis patients. OBJECTIVE: This study aimed to determine the relationship of self-acceptance with decision-making duration in cancer patients to perform a mastectomy. METHODS: An analytic observation method with cross-sectional design. The samples were taken by purposive sampling method with 50 samples of breast cancer patients. Data collected include age, last level of education, marital status, profession, stage of cancer during mastectomy, self-acceptance score, and decision-making duration to perform a mastectomy. RESULTS: The data analyzed with the Kruskal–Wallis test. The test showed the relationship of self-acceptance (p = 0.027) with decision-making duration in breast cancer patients to perform a mastectomy. CONCLUSION: In conclusion, there is a relationship of self-acceptance with decision-making duration in breast cancer patients to perform a mastectomy.
Lipocalin 2 could predict circulating MMP9 levels in patients with breast cancer
Authors: Bahrun Uleng , Wildana Wildana , Rahmawati Hegaria , Kurniawan Liong Boy , Hamdani William 
Published: May 2021

OBJECTIVES: Breast cancer is the most prevalent carcinoma found in Indonesian women, and its incidence remains high worldwide. Lipocalin 2 has been linked with the progression of breast cancer. Matrix metalloproteinase 9 (MMP9) is an enzyme that has an important role in angiogenesis. We investigated the relationship between lipocalin 2 and MMP9 and the ability of lipocalin 2 for predicting MMP9 levels in female patients with breast cancer. METHOD: A total of 55 female patients with breast cancer were enrolled in this cross-sectional study. Lipocalin 2 and MMP9 were measured by enzyme-linked immunosorbent assay. RESULTS: Lipocalin 2 was significantly correlated with MMP9 levels (r = 0.756, p < 0.001). Lipocalin 2 levels could describe the MMP9 levels (𝛽 = 0.76, p < 0.001, R2 = 56.9%). CONCLUSION: Higher lipocalin 2 levels in female patients with breast cancer indicate higher MMP9 levels. Lipocalin 2 can be used to predict MMP9 levels.
PBRM1 Mutations as a Predictive Biomarker for Immunotherapy in Metastatic Renal Cell Carcinoma: A Systematic Review
Authors: Dias Carneiro André Paternò Castello , Marques Monteiro Fernando Sabino , Soares Andrey 
Published: May 2021

INTRODUCTION: Genomic features linked to prediction of response to immunotherapy in metastatic renal cell carcinoma (mRCC) are still lacking. Protein polybromo-1 (PBRM1) mutations have been studied as a potential biomarker of clinical benefit, with conflicting published data so far. MATERIAL AND METHODS: This systematic review was guided by the standards of the PRISMA statement to identify studies involving mRCC, immunotherapy and mutations in PBRM1. The main objective was to assess the relationship between PBRM1 mutations and response to immune checkpoint inhibitors (ICI) in patients with mRCC. RESULTS: After an initial search that identified 422 studies, 8 studies met the eligibility criteria and were selected for the final analysis. Data are included from 2 trials in the first-line treatment setting, and 6 trials in second- or later treatment lines evaluating the relationship between the presence of PBRM1 mutations and clinical benefit (CB) with ICI treatment. Regarding the first-line treatment setting, the analysis of both studies failed to show any CB in patients with PBRM1 mutations treated with ICI. However, for the second- and later treatment lines, the results were mixed. CONCLUSIONS: PBRM1 mutations may be a potential genomic biomarker to predict response to ICI treatment in patients with mRCC, mainly in second- and later treatment lines, but the existence of conflicting data in the literature highlights an important bias in the studies and the need for additional clinical validation in large, prospective trials.
Índice de Bienestar Económico Sostenible de España, ¿son compatibles bienestar y sostenibilidad?
Authors: O`Mahony Tadhg 
Published: May 2021

El desafío de la sostenibilidad ha impulsado la búsqueda de indicadores económicos
alternativos, como el ĺndice de Bienestar Económico Sostenible (ISEW). Este indicador comienza
con el gasto en consumo, y a partir de ahí añade o sustrae, dependiendo de casos, otras variables
que se consideran importantes para el bienestar y la sostenibilidad. El artículo reflexiona sobre
el primer ISEW calculado para España, comparándolo con los datos de otros indicadores de
desarrollo. Los resultados demuestran que, a pesar de décadas de crecimiento económico, los
beneficios para el bienestar del ciudadano medio han sido escasos. Sobre esa base, se discuten
los usos y limitaciones del ISEW, junto con los avances recientes en la medición y comprensión
del progreso, el bienestar y la sostenibilidad.
Las bases materiales del desarrollo económico en España (1860-2016). Un estudio desde el metabolismo social
Authors: Infante-Amate Juan , Vila Jaume , Aguilera Eduardo , Sanjuán Ángel , Oropesa Felipe , González de Molina Manuel 
Published: May 2021

En este trabajo presentamos una serie histórica de los indicadores de extracción, comercio
y uso de materiales recogidos en la metodología de la Contabilidad del Flujo de Materiales,
un sistema armonizado internacionalmente para cuantificar el uso de recursos a nivel regional.
Con los resultados obtenidos analizamos la transición al metabolismo industrial en España,
observando: i) un rápido aumento en el consumo de materiales (se cuadruplican en términos
per cápita) y en la transición al uso de recursos no renovables, especialmente entre 1960 y 2007;
ii) transición de exportador neto (hasta c. 1930) a importador neto (desde c. 1960); iii) continuada
caída de la intensidad material; y iv) fuerte caída en el uso de materiales tras la Gran Recesión.
An Educational Video For Earthquake Disaster Preparedness In Students At St. Aloysius Weetabula Christian Middle School, Southwest Sumba
Authors: Metrikayanto Wahyu Dini , Valabia Valabia Gonsalves 
Published: May 2021

Bencana gempa bumi dapat memberikan dampak bahaya dan ancaman atau kerugian bagi masyarakat. Diperlukan upaya untuk mencegah dan meminimalisir dampak dari gempa bumi. Edukasi kesiapsiagaan bencana dengan media video dinilai efektif dalam peningkatan kesiapsiagaan bencana gempa bumi. Tujuan penelitian ini untuk mengetahui pengaruh edukasi video kesiapsiagaan bencana gempa bumi pada siswa SMPK St. Aloysius Weetabula Sumba Barat Daya. Desain penelitian menggunakan One-Group Pra-Post Test Design. Penelitian ini dilakukan di SMPK St Aloysius Weetabula Sumba Barat Daya pada 25 februari – 6 Maret 2020. Populasi penelitian ini adalah 338 siswa – siswi di SMPK St Aloysius Weetabula Sumba Barat Daya dan sampel sejumlah 327 responden dengan teknik simple random sampling. Variabel dependent dalam penelitian ini adalah kesiapsiagaan bencana gempa bumi. Instrumen pengumpulan data berupa kuesioner. Analisa data bivariat yang digunakan yaitu uji marginal homogeneity (p value < 0,05). Hasil penelitian menunjukkan bahwa sebelum diberikan edukasi video kesiapiagaan bencana sebagian besar peserta (59,9%) memiliki kesiapsiagaan kurang sedangkan sesudah edukasi video, sebagian besar peserta (54,1%) memiliki kesiapsiagaan baik. Hasil uji marginal homogeneity menunjukkan p value= (0,000).
Foville Syndrome Due to Pontine Hemorrhage and Pontine Infarct: Case Series
Authors: Imran I  , Syahrul S  , Nurul Fajri  
Published: May 2021

Foville Syndrome is a rare clinical feature of stroke or brain hemorrhage. Few cases have been reported worldwide particularly in Asian, Indonesia, Aceh. Patient 1: We report the case of a female 64 years old patient, was admitted in the Neurology Department of Dr. Zainoel Abidin General Hospital, Banda Aceh, Indonesia, for an abrupt onset of right body side weakness two day before admission. That weakness was preceded by acute headaches and rotatory vertigo with vomiting. with hypertension history since 5 years. Physical examination found paralysis of right oculomotor movements with intact response of pupils to light, right trochlear nerve palsy, left ipsilateral facial nerve palsy, and right hemiparesis which constitute of Foville syndrome. The brain CT scan shown in the right pontine hypodensity area is pontine infarct. Etiological investigations done to chronic hypertension. Patient received antiplatelet therapy and control of vascular risk factors for secondary prevention (hypertension theraphy), and physiotherapy as treatment with clinical improvement. And she has been discharge 8 days later. Patient 2: 45-year-old right-handed female, was admitted in the Neurology Department of Dr. Zainoel Abidin General Hospital, Banda Aceh, Indonesia, for an abrupt onset of right body side weakness two day before admission. That weakness was preceded by acute headaches and rotatory vertigo with vomiting. with hypertension history since 5 years. Physical examination found paralysis of right oculomotor movements with intact response of pupils to light, right trochlear nerve palsy, left ipsilateral facial nerve palsy, and right hemiparesis which constitute of Foville syndrome. The brain CT scan shown spontaneous hemorrhage in the left pontine’s. Etiological investigations done to chronic hypertension. Patient received therapy control of vascular risk factors for secondary prevention (hypertension theraphy), and physiotherapy as treatment with clinical improvement. And she has been discharge 10 days later. The diagnosis and management of brainstem stroke bring a considerable burden to the healthcare system, the patient, the family members, and the society at large. The slow increase in the global burden of stroke has been steadily increasing.
Potential Stunting in Riverside Peoples (Study on Pahandut Urban Village, Palangka Raya City)
Authors: Shinta Herlina Eka , Utami Purnama Julia , Adiwijaya Saputra 
Published: May 2021

The purpose of this study was to determine the potential occurrence of stunting for residents who live on the river side, especially residents who live and inhabit the Kahayan River. And the subject is women who are pregnant, have a toddler. The study was conducted with a qualitative method, a descriptive approach used to explain stunting potential for people who live on riverside. This study uses purposive sampling, data collection techniques used: interviews, observation and documentation. The findings of this study are the environmental health conditions of people who live on riverside are very bad, if it refers to WHO standards, because there are no adequate sanitation facilities related to water management and disposal of solid and liquid waste, plus the habits of people who still throw garbage directly into the river. Environmental health in the community should be improved through collaboration of various institutions, in process to change the behavior patterns of disposing of garbage in the river. Second Findings the potential for stunting in the riverside communities is quite large, because the majority of peoples doesn’t count nutritional content in food, so awareness and empowerment should be done. So that in the future there will be an increase in the quality of health of children, mothers and adolescents.
Rapid Neurodevelopmental Assessment (RNDA) : An Important Tool for Assessment of Psychomotor Development in Children with Perinatal Events
Authors: Das Dhananjoy , Sultana Kawsar , Ali Golam Mohammed Tayeb , Barua Tanuka , Arzu Mahmood A Chowdhury 
Published: May 2021

Background: Infants with various perinatal events are at risks for long term neurodevelopmental impairments. Neurodevelopmental assessment at early life has been considered as a valuable tool for prediction of neurodevelopmental outcomes in this population. This present study aimed to identify the neurodevelopmental impairments in high risk children by Rapid Neurodevelopment Assessment (RNDA)
Materials and methods : This was a cross sectional study conducted in the Autism and Child Development Centre of Chattogram Maa Shishu-O-General Hospital during the period of 0ctober to December 2018. Babies aged 0 -2 years with different perinatal events like prematurity, birth asphyxia, neonatal jaundice, and without any adverse event; that attended RNDA clinic underwent Rapid Neurodevelopmental Assessment (RNDA) to find at risk children for long term neurodevelopmental impairments.
Results: Among the 50 study subjects,Perinatal asphyxia was found in 41(82%). 26(52%) had history of IUGR, 22(44%) had Preterm delivery and 25(50%) had history of Neonatal convulsion. History of neonatal jaundice was found in 14(28%) cases. 5(10%) children did not have any perinatal event. The Mean ± SD age of study subjects was 7.38±7.31month. Severe impairment in gross motor and fine motor function were found in 25(50%) and 24(48%) respondents respectively. Vision was severely impaired in 10(20%) cases. Severe cognition and behavior impairment were found in 8(16%) and 3(6%) cases accordingly. Severe hearing and speech impairment were found in 2(4%) & 10(20%) cases respectively. Severe seizure was found in 19(39%) cases. Study subjects with the history of delayed cry or Perinatal asphyxia had significantly decreased fine motor skills. Children born with IUGR had significant gross motor and fine motor skill impairment. Significant speech & cognitive impairment were observed in children with neonatal jaundice. Seizure was found significant in study subjects with a history of neonatal convulsion.
Conclusion: Rapid Neurodevelopment Assessment (RNDA) plays an important role for early identification of neurodevelopmental impairments of high-risk infants and thus screening for these can promote early therapeutic intervention and subsequent follow up, leading to better outcome.
Chatt Maa Shi Hosp Med Coll J; Vol.20 (1); January 2021; Page 16-21