bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring maternal nutrition counseling provided by health professionals during antenatal care follow-up: a qualitative study in Addis Ababa, Ethiopia-2019
Authors: Alehegn Matyas Atnafu , Fanta Tsegaye Kebede , Ayalew Agumas Fentahun 
Published: June 2021

AbstractBackgroundNutritional awareness and practice of women during pregnancy could be determining their nutritional status, which significantly affects the outcome of pregnancy. Therefore this study aimsto explore the maternal nutrition counseling provided by health professionals for pregnant women, Barriers to maternal nutrition, and major interventions.MethodsA descriptive study design with a qualitative method by using ground theory tradition, based on constructivist research approach and Charmaz’s (2000) study design has been conducted from September-01/2019 _November-16/2019 among pregnant women who got ANC service in Addis Ababa, Ethiopia. A purposive sampling technique was used. Practical observations and in-depth interviews were conducted. The sample size adjustment has been carried out according to the information saturation obtained, and finally, 81 practical observations, In-depth interview with two center managers, nine health professionals and eleven term pregnant women has been conducted. An observational checklist and Semi-structured, open-ended questionnaires were used. Data, the environment, and methodological triangulation were carried out. A conceptual framework has been established based on the data collected about the whole process of maternal nutrition counseling during pregnancy. ATLAS TI software was utilized for information analysis.The resultsMost participants responded that maternal nutrition counseling provided to pregnant mothers is not adequate and neglected by most stakeholders. From 81 practical observations, health professionals counseled to mothers were 10 what to feed, 4 what to limit to consume, and 5 were counseled about what to eat during pregnancy. Close to all the respondents agreed on the importance of providing nutrition counseled by the nutritionists. Most of the study participants emphasized a shortage of time as primary barriers. Institutional Barriers, Professional Barriers, Maternal Barriers, and Community Barriers were major barriers to nutrition counseling.ConclusionsGenerally, maternal nutrition counseling provided to pregnant mothers was not adequate and neglected by most stakeholders. Shortage of time due to client flow, Institutional Barriers, Professional Barriers, Maternal Barriers, and Community Barriers were major categories of maternal nutritional counseling barriers. Information update and timely preparation were recommended to health professionals.
Underweight and overweight/obesity among adults in Afghanistan: prevalence and correlates from a national survey in 2018
Authors: Pengpid Supa , Peltzer Karl 
Published: June 2021

Abstract
Background
The study aimed to estimate the prevalence and correlates of underweight and overweight/obesity among adults in Afghanistan.

Methods
National cross-sectional survey data of 3779 persons aged 18–69 years were analysed. Multinomial logistic regression was used to estimate factors associated with underweight and overweight/obesity relative to normal weight.

Results
In all, 7.8% of the study sample was underweight (BMI < 18.5 kg/m2), 49.5% had normal weight (BMI 18.5–24.9 kg/m2), 25.5% overweight (25.0–29.9 kg/m2), and 17.2% obesity. In adjusted multinomial logistic regression, factors negatively associated with underweight were male sex (adjusted relative risk ratio (ARRR): 0.30, 95% confidence interval (CI): 0.15–0.58) and hypertension (ARRR: 0.51, 95% CI: 0.27–0.95) and factors positively associated with underweight were sedentary behaviour (ARRR: 1.85, 95% CI: 1.11–3.10) and current tobacco use (ARRR: 2.58, 95% CI: 1.08–6.16). Factors positively associated with overweight/obesity were aged 30–44 years (ARRR: 2.00, CI: 1.51–2.66) and aged 45–69 years (ARRR: 1.58, CI: 1.09–2.31) (compared to 18–29 years) (ARRR: 1.28, CI: 1.14–2.18), hypertension (ARRR: 2.74, CI: 1.89–3.96), and type 2 diabetes (ARRR: 1.82, CI: 1.13–2.94), and high physical activity (ARRR: 0.70, CI: 0.50–0.98) was negatively associated with overweight/obesity.

Conclusion
Almost one in ten adult respondents were underweight and more than two in five were overweight/obese, confirming a dual burden of malnutrition in Afghanistan.
Stereotactic guide for posterior approach to lateral ventricle
Authors: Chand Aatman , Chand Ashis K. , Patil Arun Angelo , Chhabra Manmeet Singh 
Published: June 2021

Abstract
Background
Free-hand tapping of the lateral ventricle through the posterior approach is a standard procedure. There are occasions, however, when more than one pass is needed. One way to make it easy and safe is to use a neuro-navigation approach. This requires extra setup. Therefore, the authors in this paper describe the use of a simple device to accurately place the catheter tip in the frontal horn.

Main body
The device is rectangular with two open arms with co-linear free ends. Based on axial CT or MR images, a trajectory that travels within the ventricle from the posterior to the anterior horn is chosen. The anterior and posterior points of the trajectory are marked on the scalp. A burr hole is placed at the posterior point. The anterior free end is then attached to the anterior trajectory point on the scalp using an EKG pad and to the posterior to a plug placed in the burr hole. The ventricle is tapped through a central hole in the burr hole plug. All 12 patients had accurate catheter placement at the first attempt using this system.

Short conclusion
This is a simple device that used CT or MR images and surface markings to accurately tap the ventricle.
Metformin induces apoptosis via uterus mitochondrial permeability transition pore opening and protects against estradiol benzoate-induced uterine defect and associated pathophysiological disorder in female Wistar rats
Authors: Olowofolahan Adeola Oluwakemi , Paulinus Obinna Matthew , Dare Heritage Mojisola , Olorunsogo Olufunso Olabode 
Published: June 2021

AbstractBackgroundSome antitumor or anticancer agents have been shown to execute cell death by induction of mitochondrial permeability transition (mPT) pore opening in order to elicit their chemotherapeutic effect. Therefore, this study investigated the effect of metformin on cell death via rat uterus mPT pore and estradiol benzoate-induced uterine defect and associated pathophysiological disorder in female rat. Mitochondria were isolated using differential centrifugation. The mPT pore opening, cytochrome c release and mitochondrial ATPase activity were determined spectrophotometrically. Caspases 9 and 3 activities, MDA and estradiol levels and SOD, GSH activities, were determined using ELISA technique. Histological and histochemical assessments of the uterine section were carried out using standard methods.ResultsMetformin at concentrations 10–90 μg/mL, showed no significant effect on mPT pore opening, mATPase activity and release of cytochrome c. However, oral administration of metformin caused mPT pore opening, enhancement of mATPase activity and activation of caspases 9 and 3 significantly at 300 and 400 mg/kg. Metformin protected against estradiol benzoate (EB)-induced uterine defect and other associated pathophysiological disorder. It also improved the antioxidant defense system. The histological evaluation revealed the protective effect of metformin on the cellular architecture of the uterus while the histochemical examination showed severe hyperplasia in the uterine section of EB-treated rats, remarkably reversed by metformin co-treatment.ConclusionThis study suggests that metformin at high doses induces apoptosis via rat uterus mPT pore opening and protects against EB-induced uterine defect (hyperplasia) and associated pathophysiological disorder.
Antibiotic resistance and plasmid analysis of Enterobacteriaceae isolated from retail meat in Lagos Nigeria
Authors: Uzeh Roseline Ekiomado , Adewumi Fadekemisola , Odumosu Bamidele Tolulope 
Published: June 2021

Abstract
Background
The presence of antibiotic resistant microorganisms in food is of great concern globally. This research was carried out to detect and characterize plasmid carriage and profiles among members of Enterobacteriaceae from different meat types in Nigeria.

Method
From a total of 80 meat samples comprising of mutton, pork, beef and chicken, organisms belonging to the family Enterobacteriaceae were isolated by standard procedures and identified by API 20E system. Antibiotics susceptibilities testing (AST) against selected classes of antimicrobial agents and plasmid extraction was carried out by disc diffusion and alkaline lysis methods respectively.

Results
One-hundred and ten Enterobacteriaceae were isolated, species identification revealed isolates belonging to 7 genera comprising of Escherichia, Enterobacter, Klebsiella, Citrobacter, Proteus, Salmonella and Serratia. Overall resistance of the organisms to amoxycillin/clavulanic acid was 91 (82.7%), streptomycin 85 (75.7%) and perfloxacin 74 (67.2%) while ofloxacin had the highest susceptibility rate (91.8%). Plasmids profiling revealed ranges of plasmids from1 to 3 copies with estimated sizes range of 700bp to 1.1kb among E. coli, K. pneumoniae, E. aerogenes and Proteus mirabilis. All the isolates with plasmids were multidrug resistant and were isolated from chicken except a strain of E. coli from pork which harboured a single plasmid copy suggesting these meat as reservoirs for antibiotic resistant bacteria.

Conclusion
Our findings revealed high level of meat contamination with antibiotic resistant Enterobacteriaceae harbouring resistant plasmids. An integrated surveillance system and safety practice must be ensured among the processors and retailers.
An unusual case report of mitral valve apparatus sparing left atrial appendage vegetation presenting as endogenous endophthalmitis
Authors: Kumar Rupesh , Bansal Vidur , Halder Vikram , Chakraborty Nirupan Sekhar , Gourav Krishna Prasad 
Published: June 2021

Abstract
Background
Ocular manifestations of infective endocarditis are nonspecific and rare. Endophthalmitis, retinal artery occlusion, Roth spots and vitreal and retinal infiltrations can all be seen with infective endocarditis. Also, infective endocarditis involving the left atrial appendage with no involvement of the mitral valve apparatus is a rarity.

Case presentation
Here we report a case of infective endocarditis of the heart involving the left atrial appendage presenting with features of endogenous endophthalmitis which ultimately progressed to phthisis bulbi with subtle cardiac symptoms in a previous healthy young adult.

Conclusion
Infective endocarditis involving the left chambers of the heart carries an inherent high risk of systemic embolization. Panophthalmitis which is considered to be the most severe form of endogenous endophthalmitis is a rare presenting feature. Although a definitive treatment algorithm is lacking, early surgery and parenteral antibiotics along with local antibiotic injections could help to save the vision.
Aiming for minimally invasive treatment of pediatric acute appendicitis in a district hospital
Authors: Kimura Toshiro , Toyoki Yoshikazu , Ichisawa Aika , Yamada Takahiro , Wakasa Yusuke , Jin Hiroyuki , Nakai Makoto , Aoki Kazunori , Kawashima Hiroaki , Endo Masaaki 
Published: June 2021

AbstractBackgroundAppendicitis is the most common cause of acute abdomen. Although emergency surgery used to be the standard treatment for both simple and complex appendicitis, there are now options for interval surgery, laparoscopic surgery, and even non-surgical treatment. In this study, we aimed to establish better treatment strategies for pediatric acute appendicitis and to find out whether minimally invasive treatment is superior to the traditional open approach. We retrospectively reviewed the cases of acute appendicitis treated in our hospital during the period from 2013 to 2018. The patients who underwent appendectomy were divided into four groups. Group 1 underwent early appendectomy with open approach, group2 underwent interval appendectomy with open approach, group 3 underwent early appendectomy with laparoscopic approach, and group 4 underwent interval appendectomy with laparoscopic approach. In addition to the above groups, the non-surgical treatment group was also studied. Clinical presentation, laboratory findings, imaging results, operative time, morbidity, and length of hospital stay were reviewed.ResultsOne hundred six children’s records were reviewed. Thirty-five of them were selected for non-surgery as they were cases with no fecal stone and first onset appendicitis, and 15 of these 35 patients (42.9%) relapsed after antibiotic treatment. As for the appendix diameter, the relapse group was significantly larger than the non-relapse group (p=0.007). In cases of surgery, group 4 had significantly less intraoperative blood loss than group 1 (p<0.001). Group 4 had significantly fewer postoperative complications than groups 1 and 2 [group 4 vs. group 1 (p=0.009), group 4 vs. group 2 (p=0.034)]. The postoperative hospital stay in groups 2 and 4 were significantly shorter than group 1 [group 1 vs. group 2 (p=0.015), group 1 vs. group 4 (p<0.001)]. On the contrary, group 1 had significantly shorter total hospital stay than groups 2 and 4 [group 1 vs. group 2 (p=0.029), group 1 vs. group 4 (p<0.001)].ConclusionInterval laparoscopic appendectomy and non-surgical treatment were safe and effective in children. From the viewpoint of avoiding unnecessary emergency surgery and prolonged hospitalization, we believe that interval laparoscopic appendectomy or non-surgical treatment should be performed after identifying patients who do not require surgery, paying attention to the risk factors for relapse.
Randomized Phase III Postoperative Trial of Platinum-Based Chemotherapy Versus Capecitabine in Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy: ECOG-ACRIN EA1131
Authors: Mayer Ingrid A. , Zhao Fengmin , Arteaga Carlos L. , Symmans William F. , Park Ben H. , Burnette Brian L. , Tevaarwerk Amye J. , Garcia Sofia F. , Smith Karen L. , Makower Della F. , Block Margaret , Morley Kimberly A. , Jani Chirag R. , Mescher Craig , Dewani Shabana J. , Tawfik Bernard , Flaum Lisa E. , Mayer Erica L. , Sikov William M. , Rodler Eve T. , Wagner Lynne I. , DeMichele Angela M. , Sparano Joseph A. , Wolff Antonio C. , Miller Kathy D. 
Published: June 2021

PURPOSEPatients with triple-negative breast cancer (TNBC) and residual invasive disease (RD) after completion of neoadjuvant chemotherapy (NAC) have a high-risk for recurrence, which is reduced by adjuvant capecitabine. Preclinical models support the use of platinum agents in the TNBC basal subtype. The EA1131 trial hypothesized that invasive disease-free survival (iDFS) would not be inferior but improved in patients with basal subtype TNBC treated with adjuvant platinum compared with capecitabine.PATIENTS AND METHODSPatients with clinical stage II or III TNBC with ≥ 1 cm RD in the breast post-NAC were randomly assigned to receive platinum (carboplatin or cisplatin) once every 3 weeks for four cycles or capecitabine 14 out of 21 days every 3 weeks for six cycles. TNBC subtype (basal v nonbasal) was determined by PAM50 in the residual disease. A noninferiority design with superiority alternative was chosen, assuming a 4-year iDFS of 67% with capecitabine.RESULTSFour hundred ten of planned 775 participants were randomly assigned to platinum or capecitabine between 2015 and 2021. After median follow-up of 20 months and 120 iDFS events (61% of full information) in the 308 (78%) patients with basal subtype TNBC, the 3-year iDFS for platinum was 42% (95% CI, 30 to 53) versus 49% (95% CI, 39 to 59) for capecitabine. Grade 3 and 4 toxicities were more common with platinum agents. The Data and Safety Monitoring Committee recommended stopping the trial as it was unlikely that further follow-up would show noninferiority or superiority of platinum.CONCLUSIONPlatinum agents do not improve outcomes in patients with basal subtype TNBC RD post-NAC and are associated with more severe toxicity when compared with capecitabine. Participants had a lower than expected 3-year iDFS regardless of study treatment, highlighting the need for better therapies in this high-risk population.
EFEK PENAMBAHAN EVAPORATOR PADA ATMOSPHERE WATER HARVESTER (AWH) TERHADAP PERFORMA SISTEM
Authors: Mrihardjono Juli , Ariwibowo Didik , Sutrisno Sutrisno , Tadeus Dista Yoel 
Published: June 2021

Atmosphere Water Harvester (AWH) was investigated to get water collected from air in elevated performance. Improvement was performed by introducing a series-arrangement of two evaporators. Air flew through the evaporators in cross-flow. This arrangement would influence performance of the AWH system in title of COP, MHI, and specific energy consumption. The AWH was designed using vapor compression refrigeration system. Parameter measured to the system were refrigerant temperature in suction and discharge line, inlet and outlet pipe wall temperatures at evaporator and condenser, air velocity enter into evaporator, and electrical energy consumption. Instrument used in this research were refrigerant pressure-temperature gauge, K-type digital thermometer, digital fan anemometer, thermo-hygro meter, and kWh meter. Air temperature and RH data were 36,5 oC, 40%, and 19 oC, 42 % for inlet and outlet air stram at evaporator, subsequently. With air velocity 1.5 m/s, the COP of the system was 3.7. Water collected from AWH was 1.1 litres/hour with energy consumption of 1.24 kWh. The AWH could be considered as a water harvester with value of specific energy of 1.13 kWh/litre and MHI of 0,2.
Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain
Authors: Angel-Isaza Jaime , Carmona-Hernandez Juan Carlos , Narváez-Solarte William , Gonzalez-Correa Clara Helena 
Published: June 2021

AbstractWeight-related disorders affect more than half of the adult population worldwide; they are also concomitant with a state of chronic low-grade inflammation manifesting in abnormal cytokine production. The present study evaluated the effect of polyphenol and flavonoid extract fromPassiflora ligularis(granadilla) on low-grade inflammation and body weight in overweight Wistar rats. To induce weight-gain, rats were fed a chow diet with 30% sucrose water and supplemented with 2.0, 2.5, and 3.0 g/L polyphenol extracts (n= 16). The design was a 3 +1 factorial model performed for 42 days (granadilla polyphenols, 3 levels of supplementation, and 1 control group). In addition to total polyphenol and total flavonoid content, the major identified and quantified polyphenol, via UHPLC, was ferulic acid. Interleukin 6 (IL-6), and cytokine tumor necrosis factor-alpha (TNF-α) were evaluated in serum. A decline in the concentration of TNF-α and in weight-gain was found inP. ligularis(granadilla) groups treated with the 2.5 g/L dose. Consumption of polyphenol extracts from granadilla inhibits interleukin-activity as an indicator of inflammation and aids in body-weight control, considering similar food intake, in overweight Wistar rats.
Segmentation of MRI Brain Tumor Image using Optimization based Deep Convolutional Neural networks (DCNN)
Authors: Mishra Pradipta Kumar , Satapathy Suresh Chandra , Rout Minakhi 
Published: June 2021

Abstract
Segmentation of brain image should be done accurately as it can help to predict deadly brain tumor disease so that it can be possible to control the malicious segments of brain image if known beforehand. The accuracy of the brain tumor analysis can be enhanced through the brain tumor segmentation procedure. Earlier DCNN models do not consider the weights as of learning instances which may decrease accuracy levels of the segmentation procedure. Considering the above point, we have suggested a framework for optimizing the network parameters such as weight and bias vector of DCNN models using swarm intelligent based algorithms like Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Gray Wolf Optimization (GWO) and Whale Optimization Algorithm (WOA). The simulation results reveals that the WOA optimized DCNN segmentation model is outperformed than other three optimization based DCNN models i.e., GA-DCNN, PSO-DCNN, GWO-DCNN.
Viewpoint: AI as Author – Bridging the Gap Between Machine Learning and Literary Theory
Authors: Van Heerden Imke , Bas Anil 
Published: June 2021

Anticipating the rise in Artificial Intelligence’s ability to produce original works of literature, this study suggests that literariness, or that which constitutes a text as literary, is understudied in relation to text generation. From a computational perspective, literature is particularly challenging because it typically employs figurative and ambiguous language. Literary expertise would be beneficial to understanding how meaning and emotion are conveyed in this art form but is often overlooked. We propose placing experts from two dissimilar disciplines – machine learning and literary studies – in conversation to improve the quality of AI writing. Concentrating on evaluation as a vital stage in the text generation process, the study demonstrates that benefit could be derived from literary theoretical perspectives. This knowledge would improve algorithm design and enable a deeper understanding of how AI learns and generates.
This article appears in the special track on AI and Society.
Factors affecting clinical phenotype in children with neurofibromatosis type 1
Authors: ÇALIŞKAN KAMIŞ Şule , YAĞCI-KÜPELİ Begül 
Published: June 2021

Purpose: In this study, it was aimed to evaluate the clinical, radiological and genetic features of children who were followed up with the diagnosis of Neurofibromatosis type 1 (NF-1).
Materials and Methods: Patients who were 0-18 years diagnosed with Neurofibromatosis according to National Institute of Health 1988 criteria between September 2012 and September 2019 were included in the study. Patient data were collected through patient files and hospital information system.
Results: A total of 50 patients were included in the study. The male/female ratio was 0.92. The median age at the time of diagnosis was 5.6 years (age range: 1-18 years). The most common finding was cafe-au-lait spots detected in all patients. Family history was found in 60% of the patients and consanguinity between parents in 14%. Neurofibroma was detected in 12%, Lisch nodule in 36% of the patients. Axillary freckling ratio was 82%, inguinal freckling ratio was 78%. Tumors were found in 22% of the patients, optic glioma in 12%, and plexiform neurofibroma in 6%. Focal areas of signal intensity (FASI) was found 56% in cranial magnetic resonance imaging (MRI).
Conclusion: The relationship between mutation type and clinical and radiological features in NF-1 was evaluated. There was no statistically significant difference in clinical and radiological findings between patients with or without mutation. Large-scale studies are needed to reveal the factors that determine the clinical phenotype in patients with NF-1 diagnosis.