bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Characterization of Linearizability for Holomorphic ℂ*-Actions
Authors: Kutzschebauch Frank , Schwarz Gerald W 
Published: March 2021

AbstractLet $G$ be a reductive complex Lie group acting holomorphically on $X=\mathbb{C}^n$. The (holomorphic) Linearization Problem asks if there is a holomorphic change of coordinates on $\mathbb{C}^n$ such that the $G$-action becomes linear. Equivalently, is there a $G$-equivariant biholomorphism $\Phi \colon X\to V$ where $V$ is a $G$-module? There is an intrinsic stratification of the categorical quotient $X/\!\!/G$, called the Luna stratification, where the strata are labeled by isomorphism classes of representations of reductive subgroups of $G$. Suppose that there is a $\Phi $ as above. Then $\Phi $ induces a biholomorphism ${\varphi }\colon X/\!\!/G\to V/\!\!/G$ that is stratified, that is, the stratum of $X/\!\!/G$ with a given label is sent isomorphically to the stratum of $V/\!\!/G$ with the same label. The counterexamples to the Linearization Problem construct an action of $G$ such that $X/\!\!/G$ is not stratified biholomorphic to any $V/\!\!/G$. Our main theorem shows that, for a reductive group $G$ with $\dim G\leq 1$, the existence of a stratified biholomorphism of $X/\!\!/G$ to some $V/\!\!/G$ is not only necessary but also sufficient for linearization. In fact, we do not have to assume that $X$ is biholomorphic to $\mathbb{C}^n$, only that $X$ is a Stein manifold.
Performance of 4 Automated SARS-CoV-2 Serology Assay Platforms in a Large Cohort Including Susceptible COVID-19–Negative and COVID-19–Positive Patients
Authors: Ward Matthew D , Mullins Kristin E , Pickett Elizabeth , Merrill VeRonika , Ruiz Mark , Rebuck Heather , Duh Show-Hong , Christenson Robert H 
Published: March 2021

Abstract

Background
Anti–SARS-CoV-2 serological responses may have a vital role in controlling the spread of the disease. However, the comparative performance of automated serological assays has not been determined in susceptible patients with significant comorbidities.

Methods
In this study, we used large numbers of samples from patients who were negative (n = 2030) or positive (n = 112) for COVID-19 to compare the performance of 4 serological assay platforms: Siemens Healthineers Atellica IM Analyzer, Siemens Healthineers Dimension EXL Systems, Abbott ARCHITECT, and Roche cobas.

Results
All 4 serology assay platforms exhibited comparable negative percentage of agreement with negative COVID-19 status ranging from 99.2% to 99.7% and positive percentage of agreement from 84.8% to 87.5% with positive real-time reverse transcriptase PCR results. Of the 2142 total samples, only 38 samples (1.8%) yielded discordant results on one or more platforms. However, only 1.1% (23/2030) of results from the COVID-19–negative cohort were discordant. whereas discordance was 10-fold higher for the COVID-19–positive cohort, at 11.3% (15/112). Of the total 38 discordant results, 34 were discordant on only one platform.

Conclusions
Serology assay performance was comparable across the 4 platforms assessed in a large population of patients who were COVID-19 negative with relevant comorbidities. The pattern of discordance shows that samples were discordant on a single assay platform, and the discordance rate was 10-fold higher in the population that was COVID-19 positive.
Field-Level Exposure of Bumble Bees to Fungicides Applied to a Commercial Cherry Orchard
Authors: Kuivila K M , Judd H , Hladik M L , Strange J P 
Published: March 2021

Abstract
Bumble bees, Bombus spp. (Apidae), are important native pollinators; however, populations of some species are declining in North America and agricultural chemicals are a potential cause. Fungicides are generally not highly toxic to bees, but little is known about sublethal or synergistic effects. This study evaluates bumble bee exposure to fungicides by quantifying concentrations of boscalid and pyraclostrobin in nectar and pollen collected by colonies of Bombus huntii Greene, 1860 (Hunt bumble bee) deployed in a commercial cherry Prunus avium L. orchard in the spring of 2016. Seven colonies were placed adjacent to an orchard block that was sprayed with a fungicide mixture of boscalid and pyraclostrobin and a control group of seven colonies was placed next to an unsprayed block of orchard 400 m away from the treated block. Nectar and pollen were collected daily, beginning 1 d before spray application and continuing for a total of 12 d, and analyzed for both fungicides. Fungicide concentrations varied spatially by colony and temporally by day. The highest concentrations in nectar occurred 1 and 3 d after spraying: up to 440 ng/g boscalid and 240 ng/g pyraclostrobin. Six days after application, pollen from cherry flowers contained the highest concentrations of the fungicides: up to 60,500 ng/g boscalid and 32,000 ng/g pyraclostrobin. These data can help to determine field-level fungicide concentrations in nectar and pollen and direct future work on understanding the effects of these compounds, including their interactions with important bumble bee pathogenic and beneficial symbionts.
What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology
Authors: Altulea Dania , Maassen Sjors , Baranov Maksim V , van den Bogaart Geert 
Published: March 2021

Abstract
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
A narrative review of regulatory governance factors that shape food and nutrition policies
Authors: Ngqangashe Yandisa , Goldman Sharni , Schram Ashley , Friel Sharon 
Published: March 2021

Abstract
Food composition, marketing restrictions, nutrition labeling, and taxation policies are recommended for preventing diet-related noncommunicable diseases. In view of the increasing but variable adoption of food policies globally, this narrative review examines the actors, regulatory frameworks, and institutional contexts that shape the development, design, and implementation of these policies. We found a diverse range of actors using various strategies, including advocacy, framing, and evidence generation to influence policy agendas. We identified diverse regulatory designs used in the formulation and implementation of the policies: command and control state regulation for taxes and menu labels, quasi-regulation for sodium reformulation, and co-regulation and industry self-regulation for food marketing policies. Quasi-regulation and industry self-regulation are critiqued for their voluntary nature, lack of independence from the industry, and absence of (or poor) monitoring and enforcement systems. The policy instrument design and implementation best practices highlighted in this review include clear policy goals and rigorous standards that are adequately monitored and enforced. Future research should examine how these combinations of regulatory governance factors influence policy outcomes.
Phytochrome-interacting factors interact with transcription factor CONSTANS to suppress flowering in rose
Authors: Sun Jingjing , Lu Jun , Bai Mengjuan , Chen Yeqing , Wang Weinan , Fan Chunguo , Liu Jinyi , Ning Guogui , Wang Changquan 
Published: March 2021

AbstractAs day-neutral (DN) woody perennial plants, the flowering time of roses (Rosa spp.) is assumed to be independent of the photoperiodic conditions; however, light responses of rose plants are not well understood. Chinese rose (Rosa chinensis) plants were grown under two light intensities (low light [LL], 92 μmol·m−2·s−1; or high light [HL], 278 μmol·m−2·s−1), and either with or without an end-of-day far-red (EOD-FR) treatment. Flowering was significantly delayed in the LL condition compared with the HL, but was not affected by EOD-FR treatment. The time until flowering positively corresponded with the mRNA and protein levels of phytochrome-interacting factors (PIFs; RcPIFs). The heterologous expression of RcPIF1, RcPIF3, or RcPIF4 in the Arabidopsis (Arabidopsis thaliana) pifq quadruple mutant partially rescued the mutant’s shorter hypocotyl length. Simultaneous silencing of three RcPIFs in R. chinensis accelerated flowering under both LL and HL, with a more robust effect in LL, establishing RcPIFs as flowering suppressors in response to light intensity. The RcPIFs interacted with the transcription factor CONSTANS (RcCO) to form a RcPIFs–RcCO complex, which interfered with the binding of RcCO to the promoter of FLOWERING LOCUS T (RcFT), thereby inhibiting its expression. Furthermore, this inhibition was enhanced when RcPIFs were stabilized by LL, leading to delayed flowering under LL compared with HL. Our results not only revealed another layer of PIF functioning in the flowering of woody perennial plants, but also established a mechanism of light response in DN plants.
In the service of the Filipino: the role of Catholic higher education institutions in promoting COVID-19 vaccines in the Philippines
Authors: Vicente Niku E , Cordero Dalmacito A 
Published: March 2021

Abstract
There has been a stigma and hesitancy regarding COVID-19 vaccination in the Philippines. Many Filipinos are still hesitant to be vaccinated. This paper highlights the role of the Catholic Church as a powerful institution which can influence the people not only in spiritual aspect but also in promoting public health by motivating locals to get vaccinated. This task can be specifically done through the efforts of Catholic Higher Education Institutions (HEI) that place prominence and priority on social work and mission.
The First Episode Psychosis Services Fidelity Scale 1.0: Review and Update
Authors: Addington Donald 
Published: March 2021

Abstract
The First Episode Psychosis Fidelity Scale, first published in 2016, is based on a list of essential components identified by systematic reviews and an international consensus process. The purpose of this paper was to present the FEPS-FS 1.0 version of the scale, review the results of studies that have examined the scale and provide an up-to-date review of evidence for each component and its rating. The First Episode Psychosis Services Fidelity Scale 1.0 has 35 components, which rate access and quality of health care delivered by early psychosis teams. Twenty-five components rate service components, and 15 components rate team functioning. Each component is rated on a 1–5 scale, and a rating of 4 is satisfactory. The service components describe services received by patients rather than staff activity. The fidelity rater completes ratings based on administrative data, health record review, and interviews. Fidelity raters from two multicenter studies provided feedback on the clarity and precision of component definitions and ratings. When administered by trained raters, the scale demonstrated good to excellent interrater reliability. The selection of components can be adjusted to rate programs serving patients with bipolar disorder or an attenuated psychosis syndrome. The scale can be used to assess and improve the quality of individual programs, compare programs and program networks. Researchers can use the scale as an outcome measure for implementation studies and as a process measure for outcome studies. Future research should focus on demonstrating predictive validity.
Funding for few, anticipation among all: Effects of excellence funding on academic research groups
Authors: Scholten Wout , Franssen Thomas P , van Drooge Leonie , de Rijcke Sarah , Hessels Laurens K 
Published: March 2021

AbstractIn spite of the growing literature about excellence funding in science, we know relatively little about its implications for academic research practices. This article compares organizational and epistemic effects of excellence funding across four disciplinary fields, based on in-depth case studies of four research groups in combination with twelve reference groups. In spite of the highly selective nature of excellence funding, all groups employ dedicated strategies to maximize their chances of acquiring it, which we call strategic anticipation. The groups with ample excellence funding acquire a relatively autonomous position within their organization. While the epistemic characteristics of the four fields shape how excellence funding can be used, we find that in all fields there is an increase in epistemic autonomy. However, in fields with more individual research practices a longer time horizon for grants, beyond the usual 5 years, would fit better with the research process.
Effect of Naltrexone on Interleukins 2 and 4 in a Sample of Egyptian Patients With Heroin Use Disorder: A Prospective Case-control Study
Authors: Mesalhy Omnia A.E.A. , Ali Ola S.M. , ELhabiby Mahmoud M.M. , Hassan Fatma A.Z.M. , Elgamel Omayma A. , Aufa Ola M.M. 
Published: March 2021

Objectives:
Opiates, particularly heroin, have been used for centuries for their positive reinforcing properties that lead to addiction. Naltrexone (NTX), an opioid antagonist, is capable of reducing these positive reinforcing effects. Heroin affects the immune system through its action on the interleukins (ILs). This study aimed to determine changes in the level of IL-2 and IL-4 in patients with heroin use disorder compared with healthy controls.

Materials and Methods:
This was a prospective case-control study conducted on 25 patients with heroin use disorder and 20 cross-matched healthy controls. We compared the levels of IL-2 and IL-4 between patients and controls and determined the changes that occurred to IL-2 and IL-4 during 4 different stages (during active use, 1 mo after abstinence, 1 and 4 mo after NTX treatment). It also evaluated the effect of dose and duration of heroin use on the level of ILs before and after NTX treatment.

Results:
This study revealed that patients showed a significantly lower level of IL-2 and a higher level of IL-4 in the patients’ group compared with the control group during active use and 1 month after discontinuation while these significant differences disappeared after NTX treatment. Serum IL-4 level was affected by both heroin dose and duration of use.

Conclusion:
Heroin use negatively affects immunity by changing the level of IL-2 and IL-4 while NTX reversed this effect, so the study approved the beneficial use of NTX treatment on the immunity system in patients with heroin use disorder.
Wounded Healers
Authors: Ziebarth Deborah Jean , Knighten Mary Lynne 
Published: March 2021

ABSTRACT:
Research regarding faith community nursing termination is scarce. Ziebarth (2018) surveyed faith community nurses (FCNs) who had experienced termination of their position. This article explores FCN feelings related to termination and provides an evidence-based practice component to translate the research into practice. Given that FCNs engage in deep relationships with clients, their feelings following termination express grief and lack of support. Support strategies as well as preemptive strategies that may be useful to prevent loss of an FCN position or ministry are presented.
A text mining study of topics and trends in health care management journals: 1998–2018
Authors: Zengul Ferhat D. , Oner Nurettin , O'Connor Stephen J. , Borkowski Nancy 
Published: March 2021

Background
Advances in natural language processing and text mining provide a powerful approach to understanding trending themes in the health care management literature.

Purpose
The aim of this study was to introduce machine learning, particularly text mining and natural language processing, as a viable approach to summarizing a subset of health care management research. The secondary aim of the study was to display the major foci of health care management research and to summarize the literature’s evolution trends over a 20-year period.

Methodology/Approach
Article abstracts (N = 2,813), from six health care management journals published from 1998 through 2018 were evaluated through latent semantic analysis, topic analysis, and multiple correspondence analysis.

Results
Using latent semantic analysis and topic analysis on 2,813 abstracts revealed eight distinct topics. Of the eight, three leadership and transformation, workforce well-being, and delivery of care issues were up-trending, whereas organizational performance, patient-centeredness, technology and innovation, and managerial issues and gender concerns exhibited downward trending. Finance exhibited peaks and troughs throughout the study period. Four journals, Frontiers of Health Services Management, Journal of Healthcare Management, Health Care Management Review, and Advances in Health Care Management, exhibited strong associations with finance, organizational performance, technology and innovation, managerial issues and gender concerns, and workforce well-being. The Journal of Health Management and the Journal of Health Organization and Management were more distant from the other journals and topics, except for delivery of care, and leadership and transformation.

Conclusion
There was a close association of journals and research topics, and research topics evolved with changes in the health care environment.

Practice Implications
As scholars develop research agendas, focus should be on topics important to health care management practitioners for better informed decision-making.
Feasibility and Impact of the Combined Application of Coronary CT Angiography With the HEART Pathway in Patients With Suspected Acute Coronary Syndrome
Authors: Matuskowitz Andrew J. , Obeid Jihad S. , Jennings Lindsey , Bayer Richard R. , Ramakrishnan Viswanathan , Schoepf U. Joseph , Jauch Edward C. 
Published: March 2021

Background:
This study examines the feasibility and utility of integrating coronary computed tomography angiography and the HEART Pathway into a novel accelerated diagnostic protocol—called HEART-CT—and assesses its impact as an optional interactive decision support tool (smart form) in the electronic health record.

Methods:
This was a retrospective observational study performed in 2 adult emergency departments (ED) among patients evaluated for suspected acute coronary syndrome. Primary outcomes included the rate of discharge from the ED following HEART-CT Smart Form use, 30-day major adverse cardiac events (MACE), and ED length of stay (LOS). Hypothesis-generating outcomes included the rate of Smart Form use by ED providers and whether adhering to the HEART-CT recommendations was associated with improved outcomes.

Results:
The study included 672 subjects, 78.1% of whom were discharged from the ED. HEART-CT identified 76.7% of patients with increased risk HEAR scores as safe for discharge. No patients identified as low risk by HEART-CT had MACE within 30 days. Total mean ED LOS was 4.6 hours. ED providers used the HEART-CT smart form in 19.7% of eligible patients. ED providers who followed the HEART-CT recommendations had 3.41 times higher odds of ED discharging patients with increased risk HEAR scores than nonadherent providers (95% CI, 2.20-5.27).

Conclusions:
HEART-CT reclassified a large proportion of patients as safe for discharge, maintained a high sensitivity for detecting 30-day MACE, and had an acceptable ED LOS. Future studies should test the extent to which more automated clinical decision support improves provider adoption and clinical outcomes of HEART-CT.
Tetanus, Diphtheria, Acellular Pertussis Vaccination During Pregnancy and Risk of Pertussis in the Newborn in Publicly and Privately Insured Mother-infant Pairs in the United States
Authors: Mott Katrina , Huybrechts Krista F. , Glynn Robert J. , Mogun Helen , Hernández-Díaz Sonia 
Published: March 2021

Background:
In the United States, pertussis circulation persists and primarily infects infants and children, despite routine vaccinations. To minimize infant morbidity and mortality from the disease before the first DTaP dose, the Advisory Committee on Immunization Practices recommends maternal Tdap vaccination in weeks 27–36 of pregnancy.

Methods:
Cohorts of mother-infant pairs in the Medicaid Analytic eXtract (MAX) (2010–2014) and IBM MarketScan (2011–2015) databases were analyzed to estimate the effectiveness of prenatal Tdap vaccination compared with no vaccination to prevent infant pertussis in the first 6 months. Hazard ratios were estimated with Cox proportional hazards models and adjusted for potential confounders via inverse probability weights. The impact of preterm delivery on the risk of pertussis was analyzed. Results from the 2 databases were pooled.

Results:
In MarketScan, women received Tdap vaccination before delivery in 114,067 (25.6%) of 445,638 pregnancies and in MAX, 33,286 (4.8%) of 695,262 pregnancies. Among pregnancies with preterm delivery, only 21.2% and 3.8% in MarketScan and MAX had been vaccinated. The risk of pertussis in unvaccinated term infants was 3.5 (MarketScan) and 17 (MAX) per 10,000; and in preterm infants, it was 8.4 (MarketScan) and 19.8 (MAX) per 10,000. The pooled hazard ratio for Tdap vaccination any time before delivery versus no vaccination was 0.64 [95% confidence interval (CI): 0.41–1.00]. The hazard ratio was 0.11 (95% CI: 0.03–0.36) for preterm and 0.78 (95% CI: 0.48–1.29) for term infants vaccinated before 37 weeks. The incidence of pertussis was higher and the protective hazard ratio stronger during pertussis outbreaks.

Conclusions:
Prenatal Tdap vaccination reduces the risk of pertussis infections in the infants’ first 6 months by 36%. Vaccination soon after 27 weeks of pregnancy, before when deliveries began, ensures vaccination includes those born preterm, who are at highest risk for pertussis and benefit particularly from this vaccination.
Detection of postlaser vision correction ectasia with a new combined biomechanical index
Authors: Vinciguerra Riccardo , Ambrósio Renato , Elsheikh Ahmed , Hafezi Farhad , Yong Kang David Sung , Kermani Omid , Koh Shizuka , Lu Nanji , Padmanabhan Prema , Roberts Cynthia J. , Taneri Suphi , Trattler William , Eliasy Ashkan , Jum Ikhyun , Lopes Bernardo , Padmanaban Vasanthi , Rosetta Pietro , Rost Anika , Torres-Netto Emilio A. , Vinciguerra Paolo 
Published: March 2021

Purpose:
To validate and evaluate the use of a new biomechanical index known as the Corvis biomechanical index–laser vision correction (CBI-LVC) as a method for separating stable post-LVC eyes from post-LVC eyes with ectasia.

Setting:
10 clinics from 9 countries.

Design:
Retrospective, multicenter, clinical study.

Methods:
The study was designed with 2 purposes: to develop the CBI-LVC, which combines dynamic corneal response (DCR) parameters provided by a high-speed dynamic Scheimpflug camera (CorVis ST; OCULUS Optikgeräte GmbH) and then to evaluate its ability to detect post-LVC ectasia. The CBI-LVC includes integrated inverse radius, applanation 1 (A1) velocity, A1 deflection amplitude, highest concavity and arclength, deformation amplitude ratio of 2 mm, and A1 arclength in millimeters. Logistic regression with Wald forward stepwise approach was used to identify the optimal combination of DCRs to create the CBI-LVC and then separate stable from LVC-induced ectasia. Eighty percentage of the database was used for training the software and 20% for validation.

Results:
736 eyes of 736 patients were included (685 stable LVC and 51 post-LVC ectasia). The receiver operating characteristic curve analysis showed an area under the curve of 0.991 when applying CBI-LVC in the validation dataset and 0.998 in the training dataset. A cutoff of 0.2 was able to separate stable LVC from ectasia with a sensitivity of 93.3% and a specificity of 97.8%.

Conclusions:
The CBI-LVC was highly sensitive and specific in distinguishing stable from ectatic post-LVC eyes. Using CBI-LVC in routine practice, along with topography and tomography, can aid the early diagnosis of post-LVC ectasia and allow intervention prior to visually compromising progression.