bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymeric Nanoparticle-Mediated Delivery of Oncolytic Measles Virus for Targeted Therapy in Cervical Cancer
Authors: Ahmed Hoorian , Ahmed Tahreem , Muskan Aatika , Badar Laraib , Naseer Faiza 
Published: December 2024

In the current study, a live attenuated oral measles virus (OMV) strain was utilized to create a polymeric, ligand-based nanoformulation (NF) aimed at improving cervical cancer treatment. 0.25 ml OMV was encapsulated within thiolated chitosan and coated with hyaluronic acid using ionic gelation. Characterization revealed a small particle size and cationic zeta potential. functional moieties in the NF were verified through FTIR and XRD. SEM analysis showed spherical, smooth particles with a crystalline nature. The virus exhibited a sustained release over 72 hours, and the titer was calculated at 2.98 × 10⁷ TCID50/ml, showing syncytia formation by day 5 post-infection. virus-encapsulated nanoparticles were tested against HeLa cells at varying multiplicities of infection (0.5 to 20), with IC50 values of 4.7 for OMV-NPs and 3.39 for the naked vaccine. Growth inhibition was observed after 3 days, confirmed by the cytotoxicity assay in cancer cells. This study concluded that the developed oncolytic measles virus nanoparticles provided effective, targeted, and sustained delivery, demonstrating significant anticancer potential at lower doses.
Genetic Polymorphism & Methotrexate Therapy Outcomes in Rheumatoid Arthritis
Authors: Staff Editorial 
Published: December 2024

Methotrexate (MTX) is commonly used as a disease-modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Genetic polymorphisms in key enzymes involved in MTX metabolism, such as methyl tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have been studied for their potential impact on MTX therapy outcomes in early RA patients. Zhang et al investigated a population of 32 patients in East China with early RA fulfilling the diagnostic standards of the American College of Rheumatology (ACR) was enrolled, and all of them received MTX monotherapy. Genotyping of patients MTHFR C677T and A1298C, MTRR A66G using tetra-primer ARMS-PCR method and Sanger sequencing to verify its accuracy. The distribution of the three polymorphic genotypes that were studied is in accordance with the Hardy-Weinberg genetic equilibrium. The patient pathology variables smoking (OR = 0.088, P = 0.037), drinking alcohol (OR = 0.039, P = 0.016), and males (OR = 0.088, P = 0.037) were significantly associated with non-response to MTX. Genotype, allele distribution, and genetic statistical models were not found to be related to MTX treatment response and disease activity in both the response groups and non-response groups. Their findings suggest that the MTHFR C677T, MTHFR A1298C, and MTRR A66G polymorphisms may not predict MTX clinical treatment response and disease activity in patients with early RA. The study revealed that smoke, alcohol, and males were possible influential factors for MTX non-response. Pharmgenomics Pers Med. 2023 May 2;16:407-423. doi: 10.2147/PGPM.S404949. eCollection 2023.
Molecular Docking & In Silico ADME Analysis of 5-O-Methyl-11-O-Acetylalkannin
Authors: Sardar Haseeba , Shareef Usman , Khan Haroon 
Published: December 2024

In the early phases of drug development, prediction of pharmacokinetic parameters including absorption, distribution, metabolism, and elimination (ADME), before synthesis may be helpful in the selection of candidates with less significant pharmacokinetic profiles. 5-O-methyl-11-O-acetylalkannin (MAA) is naphthoquinone isolated from the roots of Alkanna genus, Alkanna cappadocica. The aim of the present study is to predict the in silico ADME study of MAA using web tool called SwissADME. The 2D structure of the compound was drawn on Chemdraw Ultra version 8.0. The colored zone represents the optimal physicochemical region for oral bioavailability, according to the bioavailability radar, which takes into account the characteristics of flexibility, lipophilicity, saturation, size, polarity, and solubility. The pharmacokinetic properties were analyzed using the boiled egg model. The yolk-colored yellow component has a high chance of entering the brain, whereas the white portion has a high chance of being passively absorbed by the gastrointestinal tract. The study concluded that MAA did not violate the recommended ranges for Lipinski’s rule of five, rotational bond count, and Topological Polar Surface Area (TPSA). MAA also showed moderate lipophilicity and good water solubility. It did not act as a substrate for P-glycoprotein. MAA displayed a potential to inhibit CYP1A2, CYP2C19, CYP2C9 and CYP3A4. Besides that, MAA exhibited no action against CYP2D6. It exhibited a uniform and good bioavailability score of 0.55 (55%) with high gastrointestinal (GI) absorption capabilities. Additionally, the Synthetic Accessibility score of the MAA represented easy-step reactions of synthesis. MAA does not violate any of the five drug-likeness parameters including Lipinski, Muegge, Ghose, Veber, and Egan rules. As a result, MAA could be considered a promising molecule in drug discovery. Moreover, the molecular docking analysis showed the formation of a stable protein ligand complex between TNFα and the ligand molecule.
Identificação de marcadores moleculares associado à tolerância a germinação em pré-colheita em trigo
Authors: Seiboth Jenifer Karine Gish , Costa Antonio Carlos Torres da 
Published: December 2024

O objetivo deste trabalho foi identificar marcadores moleculares associados a tolerância à germinação dos grãos na espiga em trigo, avaliando uma população F2:3 oriunda de cruzamento entre cultivares suscetível e tolerante, comparando os dados fenotípicos submetidos a um sistema de chuva artificial, em relação aos dados genotípicos da população. No trabalho foi utilizado uma população F2:3 derivada dos cruzamentos entre Amad e Frontana. As espigas da população segregante foram colhidas após a maturidade fisiológica, submetidas a um ensaio de tolerância a germinação na espiga, com simulação de chuva em ambiente controlado. Foram analisados 196 materiais juntamente com os pais, dos quais foram geradas subamostras contendo de 6-8 semente de cada material os quais foram triturados em moinho e levadas para extração de DNA. Concluída a extração, as amostras foram quantificadas e diluídas, e submetidas análise em PCR em sequenciador genético com a utilização de marcadores microssatélites. Foram testados 4 marcadores moleculares localizados no cromossomo 4A. De acordo com resultados obtidos 3 genes estariam envolvidos na tolerância associado a dormência obedecendo a proporção de 9R:55S. Os marcadores Xgwm 397 e Xbarc 170 podem ser utilizados, como uma ferramenta de seleção negativa. O marcador Xgwm 397 pode ser utilizado para eliminar as plantas suscetíveis, com 93% de eficiência de seleção, e o marcador Xbarc 170 também pode ser utilizado para eliminar as plantas suscetíveis com 96,5% de eficiência de seleção, sendo o mesmo recessivo.
Three-axis flexible tube sensor with LSTM-based force prediction for alignment of electric vehicle charging ports
Authors: Saputra Hendri Maja , Pahrurrozi Ahmad , Baskoro Catur Hilman Adritya Haryo Bhakti , Nor Nur Safwati Mohd , Ismail Nanang , Rijanto Estiko , Yazid Edwar , Zain Mohd Zarhamdy Md , Darus Intan Zaurah Mat 
Published: December 2024

This paper introduces a novel three-axis flexible tube sensor designed for force measurement in electric vehicle (EV) charging port alignment, utilizing long short-term memory (LSTM) networks. The research aims to develop and validate a flexible and accurate sensor system capable of predicting multi-axis forces during alignment. The sensor integrates a magnetic sensor at the center of a flexible tube to capture three-dimensional (3-D) magnetic field variations corresponding to force changes. Fabricated using thermoplastic polyurethane (TPU) via 3-D printing technology, the sensor leverages machine learning to predict force values along the , , and axes ( , , ). Finite element method (FEM) analysis was conducted to assess the deflection characteristics of the flexible tube under various force conditions. Experimental results demonstrate that integrating LSTM significantly enhances the accuracy of force prediction, achieving an R² score exceeding 97 % for all axes, with mean squared error (MSE) values of 0.2819 for the -axis, 0.3567 for the -axis, and 2.8086 for the -axis. The sensor is capable of measuring forces up to 30 N without exceeding its elastic limits. These findings highlight the sensor’s potential for improving alignment accuracy and reliability in automated EV charging systems.
POTENCIAL BIOENERGÉTICO DE POPULAÇÕES NATURAIS DE MACAÚBA NA REGIÃO CENTRAL DO ESTADO DO TOCANTINS
Authors: Santos Adriele Cristina , Collicchio Erich , de Siqueira Guilherme Benko 
Published: December 2024

Macaúba (Acrocomia aculeata), due to its high levels of oil in the fruits, has great bioenergetic potential and offers a promising alternative to produce biofuel and other bioproducts. The objective of this study was to carry out an environmental and morphological characterization of the native populations of macaúba in the central region of the State of Tocantins, as well as to analyze their bioenergetic potential. To carry out the present study, two experimental sites were selected from the identification of 28 potential areas with natural occurrence of macaúba. Experimental Site A, located in the municipality of Lajeado, is characterized by a region of dense Cerrado-type natural vegetation, with an altitude of 230 m. Experimental Site B is in Aparecida do Rio Negro, in an area of extensive pasture and an altitude of 390 m. of the soil, morphological and biometric of the macaúba populations, as well as the analyzes to obtain the oil content of the fruits. In each site, 07 palm trees were selected after measuring height, counting the number of bunches and inflorescences and botanical identification of the species. 2 kg of fruits were collected from each of these palm trees, which were measured, pulped and then the oil content of the mesocarp and endosperm was analyzed (Bligh Method; Dyer) expressed % dry basis, and extraction time (30 and 60 min.), for each area. The results showed that there was a significant difference between the two areas regarding the average oil content, indicating that the average of Site A (30.85%) was higher than the average of Site B (20.73%). There was no significant difference between the oil content of the mesocarp (26.08%) and the endosperm (25.50%), nor in relation to the extraction time.
Tsinghua University Green Initiative Quality Strategy and its Field Applications in Northern Technical University
Authors: Majed Mohammed Salih  
Published: December 2024

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????? ??????? ??????? ????? ????? ?????? ???? ????? ??????? ??????? ,??? ?????? ??? ??? ?????? ?????? ??????? ????? ?????? ?????? ???????? ????? ?????? ?????? ??????????? ?????????? ?????? ???????
THE ROLE OF SOCIAL MEDIA PLATFORMS IN THE PANIC BULK BUYING OF GROCERY ITEMS AND SANITARY PRODUCTS DURING THE COVID-19 PANDEMIC
Authors: Da Usama Shakeel , Ali Laiba 
Published: December 2024

The Coronavirus, or COVID-19, is a global pandemic that has taken millions of lives all around the world and put all the world's economies on the brink of collapse. A major factor in causing this panic situation was Social Media Platforms because people around the world started sharing news related to COVID-19 on Social Media Platforms without fact-checking it, and by doing so, created fear and panic among people around the world, it caused many people to go in a frenzy situation, people started taking impulsive decisions, and that is the reason people all rushed towards the nearest grocery stores, supermarkets, pharmacies, and medical equipment stores to stock up on essential and non-essential grocery items and sanitary products. The sample size was 436 individuals, and the data was gathered through Google Forms. Data collection was done in the cities of Karachi, Islamabad, and Lahore. Questionnaires were designed with the help of a five-point Likert scale and dichotomous questions from previous research. The reliability of this model showed the strong consistency of the responses. SPPS software was used for testing the data by applying regression and correlation tests, and the results signified that there is a significant impact of social media platforms on panic bulk buying of grocery items, panic bulk buying of sanitary products, and herd mentality in the presence of the COVID-19 pandemic.
Англоязычные заимствования в медицинской терминологии русского и ингушского языков
Authors: Мерешкова З.И. , Мерешкова Х.Р. , Сагова М.Б. 
Published: December 2024

данная статья посвящена изучению процесса внедрения англоязычных медицинских терминов в русский и ингушский языки. Важной составляющей словарного состава любого языка является его терминологическая система, так как термины в лексической системе служат более точными обозначениями, которые характеризуют предметы или явления, относящиеся к определенной сфере. Англоязычные заимствования присутствуют во всех сферах русского и ингушского языков, и медицина не является исключением. В качестве методов исследования в данной статье используются сравнительно-исторический, сопоставительный и описательный методы. Целью настоящего исследования является анализ англоязычных заимствований проникающих в медицинскую терминологию русского и ингушского языков, а так же установление причин данного языкового явления. Практически все иноязычные термины проникают в ингушский словарный состав только посредством русского языка. Именно утвердившись в русской лексической системе, они переходят в ингушский язык. Изучая медицинскую терминологию в русском и ингушском языках, мы пришли к выводу, что англицизмы являются основным источником пополнения медицинской терминологической системы русского и ингушского языков на современном этапе.
this article is devoted to the study of the process of borrowing of terms from English into the Russian and Ingush languages. An important component of the vocabulary of any language is its terminological system, since terms serve as more precise designations that characterizes objects or phenomena of a special area. Loanwords from English present in all the spheres of the Russian and Ingush languages, and medicine is no exception. Comparative historical, comparative and descriptive methods are used as research methods in this article. The purpose of this study is to analyze English loanwords penetrating into the medical terminology of the Russian and Ingush languages, as well as to find out the causes of this linguistic phenomenon. Almost all foreign terms penetrate into the Ingush vocabulary only through the Russian language. Only after taking root in Russian vocabulary they appear in the Ingush language. In the result of the study of Russian and Ingush medical terminology, we have come to the conclusion that borrowings from the English language are the main source of updating and extending of the medical terminological system of Russian and Ingush languages in present period.
Hubungan Pola Asuh Orang Tua permisif dengan perilaku Bullying pada Anak di SD Negeri Jetis 1 Yogyakarta
Authors: Istiqomah  , Dian Fertiana Devi  , Sriyati  
Published: December 2024

Background: The problem of bullying in Indonesia continues to increase every year, with 226 cases recorded in 2022. Bullying is a crime committed by a stronger person against a weaker person. The impact of bullying on victims, such as trauma, fear, seeking escape, declining academic achievement. The impact on the perpetrators, namely when adults can become criminals. Objective: To determine the relationship between permissive parenting patterns and bullying behaviour in children at SD Negeri (state elementary school) Jetis 1 Yogyakarta. Method: Quantitative research type with correlative design and cross-sectional time approach were performed in this study. The number of respondents was 96 children taken using total sample technique. The instruments used were permissive parenting questionnaire and bullying behaviour questionnaire that had been declared valid and reliable. The data were analysed using Spearman Rank test. Results: The results of the study showed that permissive parenting patterns were mostly in the moderate category of 66 children (68.8%) and bullying behaviour was mostly in the moderate category of 50 children (52.1%). The results of the Spearman Rank statistical test analysis showed that there was a relationship between permissive parenting patterns and bullying behaviour in children at SD Negeri Jetis 1, Yogyakarta with a p value of 0.001 (p <0.05) and a correlation coefficient value of -0.337. Conclusion and suggestion: There is a relationship between permissive parenting patterns and bullying behaviour in children at SD Negeri Jetis 1 Yogyakarta. The relationship is weak, namely -0.337 (0.20-0.399). The direction of the negative correlation means that the higher the permissive parenting pattern, the lower the bullying behaviour, and vice versa, the lower the permissive parenting pattern, the higher the bullying behaviour. Parents should provide a more democratic parenting pattern so that children avoid bullying behaviour.
Influence Teacher Professionalism Towards Motivation Learning and Ability Think Critical Students in Social Studies Learning Class V SD Inpres 1 Kayumalue Tax
Authors: Ika Citra Pratiwi  , Lukman  , Misnah  
Published: December 2024

Education is all something that affects growth , change and conditions every human . The changes that happen is development potential child educate , good knowledge , skills , and attitude in his life . Ability think critical student refers to the ability For analyze , evaluate , and interpret information, ideas or problem with objective way . Formulation​ problem study How influence teacher professionalism towards motivation learning and ability think critical students in social studies learning . Research objectives This is to (1) test and find out influence teacher professionalism towards motivation learning and ability think critical students . The sample used as many as 30 students Class V of SD Inpres 1 Kayumalue Pajeko . Research This is study quantitative . The data used in study This using primary data obtained from answer Respondent on questionnaire / questions . Data analysis using the Statistical Package for the Social Sciences (SPSS) for Windows version 25 with Independent Samples Test technique . Research results This show that (1) teacher professionalism has an influence to motivation Study students , because mark ???????????? ≥ 0.005, namely 0.092. (2) teacher professionalism has an effect to ability think critical students , grades ???????????? ≥ 0.005 which is 0.089.
Formation of Religious Character Through the Islamic Character Building (ICB) Program at SD Lughatuna Bekasi City
Authors: Sodik Mugni , Haris Abdul , Yazid Syamsurizal 
Published: December 2024

The purpose of this study is to describe and analyze the formation of religious character through the Islamic character building (ICB) program at SD Lughatuna, Bekasi City. This study uses a qualitative approach with a case study type of research. The subjects of the study were the principal, ICB Coordinator, PAI teachers, and grade VI students. Data collection techniques are carried out by interviews, observations, and documentation. The validity of the data uses source triangulation. The data analysis technique uses the analysis of the interactive model of Miles, Huberman and Saldana. The results of the study show that the formation of students' religious character is carried out through teaching, stories, practices, rewards and punishments, habituation, modeling/imitation and controlling. The teaching process is carried out by integrating character values in learning, hadsith about aqidah and worship, Fiqh, Islamic stories. Habituation is carried out through the implementation of congregational prayers, murajaah of the Qur'an and hadith, speaking and behaving politely, orderly culture and queuing. Modeling is carried out by teachers and school employees by giving good examples directly to students at school. Controlling is carried out by the teachers and parents. Teachers actively communicate and collaborate with parents regarding worship and student behavior at home. Evaluations are carried out periodically and programmatically, both weekly, quarterly and yearly.
DIRETRIZES DE LINGUAGEM SIMPLES ADOTADAD PELO PODER JUDICIÁRIO BRASILEIRO EM COMPARAÇÃO COM AS DIRETRIZES DO PADRÃO INTERNACIONAL
Authors: Mendes Fernanda Lemos de Matos , Watanabe Carolina Yukari Veludo 
Published: December 2024

Por meio da comparação feita neste trabalho, verificou-se que o Poder Judiciário brasileiro tem adotado diretrizes de Linguagem Simples que estão relacionadas às diretrizes do padrão internacional estabelecido pela respectiva norma técnica ISO, de maneira relativamente uniforme.
Todavia, nota-se que a norma internacional é mais detalhada que as regulamentações dos tribunais brasileiros. Isso pode ocorrer porque a norma ISO se propõe a um caráter mais didático que os atos normativos dos tribunais.
Ainda assim, considera-se necessário realizar estudos sobre a relevância de aplicação, para o contexto das comunicações do Judiciário, de algumas diretrizes que não foram abordadas pelos tribunais.
As principais lacunas encontradas foram nos aspectos relacionados à estrutura e design dos documentos, construção de frases e parágrafos e avaliação dos documentos (por meio de revisão e de testes com o público-alvo).
Esses aspectos podem ser melhor analisados e considerados para inclusão em futuras regulamentações sobre o assunto nos demais tribunais ou ainda para inclusão em materiais didáticos (guias, manuais, cartilhas) próprios de cada tribunal.