bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a recovery-focused therapy for older people with bipolar disorder: a qualitative focus group study
Authors: Tyler Elizabeth , Lobban Fiona , Long Rita , Jones Steven H 
Published: August 2021

ObjectivesAs awareness of bipolar disorder (BD) increases and the world experiences a rapid ageing of the population, the number of people living with BD in later life is expected to rise substantially. There is no current evidence base for the effectiveness of psychological interventions for older adults with BD. This focus group study explored a number of topics to inform the development and delivery of a recovery-focused therapy (RfT) for older adults with BD.DesignA qualitative focus group study.SettingThree focus groups were conducted at a university in the North West of England.ParticipantsEight people took part in the focus groups; six older adults with BD, one carer and one friend.ResultsParticipant’s responses clustered into six themes: (1) health-related and age-related changes in later life, (2) the experience of BD in later life, (3) managing and coping with BD in later life, (4) recovery in later life, (5) seeking helping in the future and (6) adapting RfT for older people.ConclusionsParticipants reported a range of health-related and age-related changes and strategies to manage their BD. Participants held mixed views about using the term ‘recovery’ in later life. Participants were in agreement that certain adaptations were needed for delivering RfT for older adults, based on their experience of living with BD in later life. The data collected as part of the focus groups have led to a number of recommendations for delivering RfT for older adults with BD in a randomised controlled trial (Clinical Trial Registration:ISRCTN13875321).
Predominant learning approaches of medical students in Saudi Arabia
Authors: AlOmar Reem S , AlShamlan Nouf A , AlAmer Naheel A , Albrahim Nouf I , Alshulah Zainab Z , Kalalah Zahra A , Almoaibed Danah M , Alshulah Hawra Z , AlRashid Musaad R , Althumairi Abdulaziz A , Althunyan Abdullatif K 
Published: August 2021

AbstractPurpose of the studyThis study aims at identifying the predominant learning approaches by Saudi medical students across Saudi Arabia and assess its possible associations with sociodemographic and educational characteristics.Study designA cross-sectional study design using the Approaches and Study Skills Inventory for Students questionnaire. The questionnaire gives rise to three possible learning approaches; deep, strategic and surface approaches. Bivariate analyses were performed through independent samples t-test and χ2 tests where appropriate. A multinominal regression analysis was performed to obtain risk estimates and 95% CIs.ResultsA total of 3767 students participated and were included in the analysis. The predominant learning approach was the deep approach, followed by the strategic and surface approaches (40.59%, 37.81% and 21.60%, respectively). Males and students belonging to private medical schools were more likely to adopt a strategic rather than a deep one (relative risk ratio (RRR) 1.22, 95% CI 1.06 to 1.42 and RRR 1.32, 95% CI 1.05 to 1.65, respectively). Students with an A grade point average (GPA) were less likely to adopt a surface approach, whereas those with a C GPA were more likely to adopt it (RRR=0.67, 95% CI 0.54 to 0.83 and RRR=1.29, 95% CI 1.02 to 1.61, respectively).ConclusionThe findings from this study show that medical students predominantly favour the deep learning approach. Results from this study encourage the continuous adaptation of clinical teaching in medical schools to optimise students’ learning experiences.
Spin-1 resonances
Authors: De Curtis Stefania , Dominici Daniele 
Published: August 2021

AbstractSpin-1 resonances are naturally present in composite Higgs frameworks. We first review a model independent approach to parameterize a single additional heavy triplet and then we consider more realistic models arising in composite Higgs scenarios where a larger number of spin-1 resonances is expected. In these cases, finite width and interference effects can heavily affect the bounds extracted from the data.
Gene Body Methylation of the Lymphocyte-Specific GeneCARD11Results in Its Overexpression and Regulates Cancer mTOR Signaling
Authors: McGuire Michael H. , Dasari Santosh K. , Yao Hui , Wen Yunfei , Mangala Lingegowda S. , Bayraktar Emine , Ma Wencai , Ivan Cristina , Shoshan Einav , Wu Sherry Y. , Jonasch Eric , Bar-Eli Menashe , Wang Jing , Baggerly Keith A. , Sood Anil K. 
Published: August 2021

AbstractInvestigations into the function of nonpromoter DNA methylation have yielded new insights into epigenetic regulation of gene expression. Previous studies have highlighted the importance of distinguishing between DNA methylation in discrete functional regions; however, integrated nonpromoter DNA methylation and gene expression analyses across a wide number of tumor types and corresponding normal tissues have not been performed. Through integrated analysis of gene expression and DNA methylation profiles, we examined 32 tumor types and identified 57 tumor suppressors and oncogenes out of 260 genes exhibiting a correlation of &gt; 0.5 between gene body methylation and gene expression in at least one tumor type. The lymphocyte-specific gene CARD11 exhibits robust association between gene body methylation and expression across 19 of 32 tumor types examined. It is significantly overexpressed in kidney renal cell carcinoma (KIRC) and lung adenocarcinoma (LUAD) tumor tissues in comparison with respective control samples; and is significantly associated with lower overall survival in KIRC. Contrary to its canonical function in lymphocyte NFκB activation, CARD11 activates the mTOR pathway in KIRC and LUAD, resulting in suppressed autophagy. Furthermore, demethylation of a CpG island within the gene body of CARD11 decreases gene expression. Collectively, our study highlights how DNA methylation outside the promoter region can impact tumor progression.Implications:Our study describes a novel regulatory role of gene body DNA methylation–dependent CARD11 expression on mTOR signaling and its impact on tumor progression.
Relationship Between a Plant‐Based Dietary Portfolio and Risk of Cardiovascular Disease: Findings From the Women's Health Initiative Prospective Cohort Study
Authors: Glenn Andrea J. , Lo Kenneth , Jenkins David J. A. , Boucher Beatrice A. , Hanley Anthony J. , Kendall Cyril W. C. , Manson JoAnn E. , Vitolins Mara Z. , Snetselaar Linda G. , Liu Simin , Sievenpiper John L. 
Published: August 2021

Background
The plant‐based Dietary Portfolio combines established cholesterol‐lowering foods (plant protein, nuts, viscous fiber, and phytosterols), plus monounsaturated fat, and has been shown to improve low‐density lipoprotein cholesterol and other cardiovascular disease (CVD) risk factors. No studies have evaluated the relation of the Dietary Portfolio with incident CVD events.

Methods and Results
We followed 123 330 postmenopausal women initially free of CVD in the Women's Health Initiative from 1993 through 2017. We used Cox proportional‐hazard models to estimate adjusted hazard ratios (HRs) and 95% CI of the association of adherence to a Portfolio Diet score with CVD outcomes. Primary outcomes were total CVD, coronary heart disease, and stroke. Secondary outcomes were heart failure and atrial fibrillation. Over a mean follow‐up of 15.3 years, 13 365 total CVD, 5640 coronary heart disease, 4440 strokes, 1907 heart failure, and 929 atrial fibrillation events occurred. After multiple adjustments, adherence to the Portfolio Diet score was associated with lower risk of total CVD (HR, 0.89; 95% CI, 0.83–0.94), coronary heart disease (HR, 0.86; 95% CI, 0.78–0.95), and heart failure (HR, 0.83; 95% CI, 0.71–0.99), comparing the highest to lowest quartile of adherence. There was no association with stroke (HR, 0.97; 95% CI, 0.87–1.08) or atrial fibrillation (HR, 1.10; 95% CI, 0.87–1.38). These results remained statistically significant after several sensitivity analyses.

Conclusions
In this prospective cohort of postmenopausal women in the United States, higher adherence to the Portfolio Diet was associated with a reduction in incident cardiovascular and coronary events, as well as heart failure. These findings warrant further investigation in other populations.
Changes in Stroke Hospital Care During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis
Authors: Katsanos Aristeidis H. , Palaiodimou Lina , Zand Ramin , Yaghi Shadi , Kamel Hooman , Navi Babak B. , Turc Guillaume , Benetou Vassiliki , Sharma Vijay K. , Mavridis Dimitris , Shahjouei Shima , Catanese Luciana , Shoamanesh Ashkan , Vadikolias Konstantinos , Tsioufis Konstantinos , Lagiou Pagona , Sfikakis Petros P. , Alexandrov Andrei V. , Tsiodras Sotirios , Tsivgoulis Georgios 
Published: August 2021

Background and Purpose:
We systematically evaluated the impact of the coronavirus 2019 (COVID-19) pandemic on stroke care across the world.

Methods:
Observational studies comparing characteristics, acute treatment delivery, or hospitalization outcomes between patients with stroke admitted during the COVID-19 pandemic and those admitted before the pandemic were identified by Medline, Scopus, and Embase databases search. Random-effects meta-analyses were conducted for all outcomes.

Results:

We identified 46 studies including 129 491 patients. Patients admitted with stroke during the COVID-19 pandemic were found to be younger (mean difference, −1.19 [95% CI, −2.05 to −0.32];
I
2
=70%) and more frequently male (odds ratio, 1.11 [95% CI, 1.01–1.22];
I
2
=54%) compared with patients admitted with stroke in the prepandemic era. Patients admitted with stroke during the COVID-19 pandemic, also, had higher baseline National Institutes of Health Stroke Scale scores (mean difference, 0.55 [95% CI, 0.12–0.98];
I
2
=90%), higher probability for large vessel occlusion presence (odds ratio, 1.63 [95% CI, 1.07–2.48];
I
2
=49%) and higher risk for in-hospital mortality (odds ratio, 1.26 [95% CI, 1.05–1.52];
I
2
=55%). Patients with acute ischemic stroke admitted during the COVID-19 pandemic had higher probability of receiving endovascular thrombectomy treatment (odds ratio, 1.24 [95% CI, 1.05–1.47];
I
2
=40%). No difference in the rates of intravenous thrombolysis administration or difference in time metrics regarding onset to treatment time for intravenous thrombolysis and onset to groin puncture time for endovascular thrombectomy were detected.

Conclusions:
The present systematic review and meta-analysis indicates an increased prevalence of younger patients, more severe strokes attributed to large vessel occlusion, and higher endovascular treatment rates during the COVID-19 pandemic. Patients admitted with stroke during the COVID-19 pandemic had higher in-hospital mortality. These findings need to be interpreted with caution in view of discrepant reports and heterogeneity being present across studies.
An Intracranial Electrophysiology Study of Visual Language Encoding: The Contribution of the Precentral Gyrus to Silent Reading
Authors: Kaestner Erik , Thesen Thomas , Devinsky Orrin , Doyle Werner , Carlson Chad , Halgren Eric 
Published: August 2021

Abstract
Models of reading emphasize that visual (orthographic) processing provides input to phonological as well as lexical–semantic processing. Neurobiological models of reading have mapped these processes to distributed regions across occipital–temporal, temporal–parietal, and frontal cortices. However, the role of the precentral gyrus in these models is ambiguous. Articulatory phonemic representations in the precentral gyrus are obviously involved in reading aloud, but it is unclear if the precentral gyrus is recruited during reading silently in a time window consistent with participation in phonological processing contributions. Here, we recorded intracranial electrophysiology during a speeded semantic decision task from 24 patients to map the spatio-temporal flow of information across the cortex during silent reading. Patients selected animate nouns from a stream of nonanimate words, letter strings, and false-font stimuli. We characterized the distribution and timing of evoked high-gamma power (70–170 Hz) as well as phase-locking between electrodes. The precentral gyrus showed a proportion of electrodes responsive to linguistic stimuli (27%) that was at least as high as those of surrounding peri-sylvian regions. These precentral gyrus electrodes had significantly greater high-gamma power for words compared to both false-font and letter-string stimuli. In a patient with word-selective effects in the fusiform, superior temporal, and precentral gyri, there was significant phase-locking between the fusiform and precentral gyri starting at ∼180 msec and between the precentral and superior temporal gyri starting at ∼220 msec. Finally, our large patient cohort allowed exploratory analyses of the spatio-temporal reading network underlying silent reading. The distribution, timing, and connectivity results place the precentral gyrus as an important hub in the silent reading network.
The influence of the wind field and stratification on the nocturnal surface air temperature over modest topography
Authors: Mahrt L. , Fernando H. J. S , Acevedo O. 
Published: August 2021

AbstractOur study examines the horizontal variation of the nocturnal surface air temperature by analyzing measurements from four contrasting networks of stations with generally modest topography. The horizontal extent of the networks ranges from 1 to 23 km. For each network, we investigate the general relationship of the horizontal variation of temperature to the wind speed, wind direction, near-surface stratification, and turbulence. As an example, the horizontal variation of temperature generally increases with increasing stratification and decreases with increasing wind speed. However, quantitative details vary significantly between the networks. Needed changes of the observational strategy are discussed.
Effect of individualized medical nutrition guidance on pregnancy outcomes in older pregnant women
Authors: Li Chun-Ling , Wang Ying-Hua , Wang Jun-Li , Zhang Ping , Sun Yan 
Published: August 2021

Objective We aimed to explore the effect of individualized medical nutrition guidance on pregnancy outcomes among older pregnant women. Methods This was a prospective study using a randomized controlled trial design. We selected 820 older pregnant women and randomly divided them into a study group and control group (410 women each). The control group was given routine health education and nutrition guidance; the study group was provided individualized medical nutrition guidance. Gestational diabetes mellitus, hypertensive disorders of pregnancy, vaginal delivery rate, postpartum hemorrhage rate, gestational body weight, neonatal birth weight, and neonate transfer to the neonatal intensive care unit (NICU) were compared between the groups. Results The incidence of gestational diabetes in the study group was significantly lower and the rate of vaginal delivery was significantly higher than those in the control group. The incidence of macrosomia, rate of neonatal transfer to the NICU, and rate of neonatal hyperbilirubinemia were significantly lower in the study group than those in the control group. Conclusions Individualized nutritional intervention for older pregnant women can effectively reduce the incidence of complications during pregnancy and childbirth and improve maternal and child outcomes.
HCV RNA in serum and liver samples of patients undergoing living donor liver transplantation
Authors: Lin Shu-Hsien , Wu Kun-Ta , Wang Chih-Chi , Huang Kuang-Tzu , Chen Kuang-Den , Lin Chih-Che , Hsu Li-Wen , Chiu King-Wah 
Published: August 2021

Objective To compare hepatitis C virus (HCV) RNA levels from serum and explanted native liver samples from patients undergoing living donor liver transplantation (LDLT). Methods This was a prospective observational study. Serum and liver samples were collected from consecutive serum anti-HCV-positive transplant recipients between February 2016 to August 2019. HCV RNA was extracted from liver samples and subjected to one-step reverse-transcription qPCR. using the TopScript One Step qRT-PCR Probe Kit with HCV qPCR probe assay and human GAPDH qPCR probe assay on a ViiA7 Real-Time PCR System. Results Among the 80 patients, 36% (29/80) were HCV RNA positive in serum and 85% (68/80) had positive hepatic HCV RNA. Post-liver transplantation, 4% (3/80) patients were serum positive. Conclusions Our study suggests that pre-transplant serum HCV RNA levels may give an underestimate of the number of positive HCV RNA cases and that hepatic HCV RNA data may be more accurate.
Combination of AST to ALT and neutrophils to lymphocytes ratios as predictors of locally advanced disease in patients with bladder cancer subjected to radical cystectomy: Results from a single-institutional series
Authors: Uleri Alessandro , Hurle Rodolfo , Contieri Roberto , Diana Pietro , Buffi Nicolòmaria , Lazzeri Massimo , Saita Alberto , Casale Paolo , Guazzoni Giorgio , Lughezzani Giovanni 
Published: August 2021

Background: Bladder cancer (BC) staging is challenging. There is an important need for available and affordable predictors to assess, in combination with imaging, the presence of locally-advanced disease. Objective: To determine the role of the De Ritis ratio (DRR) and neutrophils to lymphocytes ratio (NLR) in the prediction of locally-advanced disease defined as the presence of extravescical extension (pT ⩾ 3) and/or lymph node metastases (LNM) in patients with BC treated with radical cystectomy (RC). Methods: We retrospectively analyzed clinical and pathological data of 139 consecutive patients who underwent RC at our institution. Logistic regression models (LRMs) were fitted to test the above-mentioned outcomes. Results: A total of 139 consecutive patients underwent RC at our institution. Eighty-six (61.9%) patients had a locally-advanced disease. NLR (2.53 and 3.07; p = 0.005) and DRR (1 and 1.17; p = 0.01) were significantly higher in patients with locally-advanced disease as compared to organ-confined disease. In multivariable LRMs, an increasing DRR was an independent predictor of locally-advanced disease (OR = 3.91; 95% CI: 1.282–11.916; p = 0.017). Similarly, an increasing NLR was independently related to presence of locally-advanced disease (OR = 1.28; 95% CI: 1.027–1.591; p = 0.028). In univariate LRMs, patients with DRR > 1.21 had a higher risk of locally advanced disease (OR = 2.83; 95% CI: 1.312–6.128; p = 0.008). Similarly, in patients with NLR > 3.47 there was an increased risk of locally advanced disease (OR = 3.02; 95% CI: 1.374–6.651; p = 0.006). In multivariable LRMs, a DRR > 1.21 was an independent predictor of locally advanced disease (OR = 2.66; 95% CI: 1.12–6.35; p = 0.027). Similarly, an NLR > 3.47 was independently related to presence of locally advanced disease (OR = 2.24; 95% CI: 0.95–5.25; p = 0.065). No other covariates such as gender, BMI, neoadjuvant chemotherapy or diabetes reached statistical significance. The AUC of the multivariate LRM to assess the risk of locally advanced disease was 0.707 (95% CI: 0.623–0.795). Limitations include the retrospective nature of the study and the relatively small sample size.
Symptomatic kidney stones in an anuric patient on dialysis: A case report
Authors: Dialameh Hossein , Namdari Farshad , Mahalleh Mehrdad , Lotfi Mohammad , Ali Zoha 
Published: August 2021

Introduction: Renal colic is a colicky-type of flank pain that can commonly be presented in patients undergoing dialysis especially if they are anuric considering the fact that there are multiple controversies and little published experience on this topic, we found it very important to report this case. We also aimed to increase awareness and emphasize the importance of renal colic in anuric patients on dialysis. Case description: We herein report a case of a 42-year old man with a chief complaint of bilateral colic flank pain, He had developed end stage renal disease due to ADPKD and was on hemodialysis since the past 5 years. Previously, he went through a series of workup but was left undiagnosed. Abdomen-pelvic and chest CT scan without contrast was performed showing bilateral renal pelvic stones and some nephrocalcinosis in both kidneys. bilateral ureteroscopy was performed and bilateral DJ was installed for a total of 6 weeks and extracorporeal shock wave lithotripsy was done. With prompt diagnosis, the patient was pain free and stone free before discharge. The patient is also reported to be stone free 6 months after the procedure. Conclusion: Patients on dialysis are still capable of forming symptomatic renal tract stones even if they are anuric.
Enhanced hydrophilicity and antifouling performance of PES-C/emodin ultrafiltration membrane
Authors: Li Jinjing , Wu Yiban , Li Baining , Hu Ming , Zhang Jie 
Published: August 2021

In this article, an ultrafiltration membrane was fabricated from phenolphthalein polyethersulfone (PES-C) modified with emodin using a phase-inversion method. ATR-FTIR and UV-vis analysis showed that emodin had good compatibility with the PES-C ultrafiltration membrane. SEM showed that the prepared ultrafiltration membranes consisted of a porous skin layer and a macroporous support sublayer. The contact angle value of the pure PES-C ultrafiltration membrane was 77.71° and that of the PES-C ultrafiltration membrane blended with 0.105 wt.% emodin decreased to 65.71°, which explained the fact why its pure water flux significantly increased from 190 L/m2·h to 387 L/m2·h. The antifouling properties of the obtained ultrafiltration membranes were assessed by static protein adsorption, bacterial adhesion, antibacterial tests, and filtration experiments with BSA. The PES-C (13.895 wt.%)/emodin (0.105 wt.%) ultrafiltration membrane presented the lowest protein adsorption rate (1.44%), the highest flux recovery ratio (57%), and the largest inhibition zone diameter (3.0 ± 0.06 mm). Compared with that of the pure PES-C ultrafiltration membrane, the bacterial adhesion effect of the PES-C/emodin (0.105 wt.%) ultrafiltration membrane was significantly reduced. In addition, PES-C incorporated into the emodin ultrafiltration membrane had excellent stability in a deionized water system.
Long-term guided wave structural health monitoring in an uncontrolled environment through long short-term principal component analysis
Authors: Yang Kang , Kim Sungwon , Yue Rongting , Yue Haotian , Harley Joel B. 
Published: August 2021

Environmental effects are a significant challenge in guided wave structural health monitoring systems. These effects distort signals and increase the likelihood of false alarms. Many research papers have studied mitigation strategies for common variations in guided wave datasets reproducible in a lab, such as temperature and stress. There are fewer studies and strategies for detecting damage under more unpredictable outdoor conditions. This article proposes a long short-term principal component analysis reconstruction method to detect synthetic damage under highly variational environments, like precipitation, freeze, and other conditions. The method does not require any temperature or other compensation methods and is tested by approximately seven million guided wave measurements collected over 2 years. Results show that our method achieves an area under curve score of near 0.95 when detecting synthetic damage under highly variable environmental conditions.