bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneity in Husbands’ and Wives’ Physical Pain Trajectories Over Mid-Later Years: Biopsychosocial Stratification and Implications for Later-Life Well-Being
Authors: Wickrama Kandauda A S , Lee Tae Kyoung , O’Neal Catherine Walker 
Published: January 2021

Abstract

Background and Objectives
The present study investigated pain trajectories of husbands and wives over their mid-later years, the grouping of these trajectories, and differences in baseline biopsychosocial profiles and health and well-being outcomes in later years across the pain trajectory groups.

Research Design and Methods
Growth mixture modeling was used to identify latent classes of 244 husbands’ and wives’ physical pain trajectories over their mid-later years (1994–2015, average ages of 44–65 years). Analyses were conducted to identify how these pain trajectory classes were associated with respondents’ biopsychosocial profiles in 1994 and health and well-being in later years (2017 [&gt;67 years]).

Results
The individual pain trajectories of husbands and wives were clustered into 3 heterogeneous groups with differing trajectory patterns. Nonnormative pain trajectory groups (with either a high pain level and/or persistent pain) were associated with adverse baseline biopsychosocial characteristics. These groups also experienced poorer health and well-being outcomes in later years (2017) compared to those with consistently low pain after controlling for lagged measures in 2015.

Discussion and Implications
The identification of pain trajectory groups and characteristics of group members provides a potentially useful prognostic tool for early preventive intervention efforts, treatment, and policy formation. Such interventions can promote and develop resiliency factors, thereby aiding in the redirection of middle-aged husbands’ and wives’ adverse pain trajectories.
Identifying the effect of vancomycin on health care–associated methicillin-resistant Staphylococcus aureus strains using bacteriological and physiological media
Authors: Rajput Akanksha , Poudel Saugat , Tsunemoto Hannah , Meehan Michael , Szubin Richard , Olson Connor A , Seif Yara , Lamsa Anne , Dillon Nicholas , Vrbanac Alison , Sugie Joseph , Dahesh Samira , Monk Jonathan M , Dorrestein Pieter C , Knight Rob , Pogliano Joe , Nizet Victor , Feist Adam M , Palsson Bernhard O 
Published: January 2021

Abstract

Background
The evolving antibiotic-resistant behavior of health care–associated methicillin-resistant Staphylococcus aureus (HA-MRSA) USA100 strains are of major concern. They are resistant to a broad class of antibiotics such as macrolides, aminoglycosides, fluoroquinolones, and many more.

Findings
The selection of appropriate antibiotic susceptibility examination media is very important. Thus, we use bacteriological (cation-adjusted Mueller-Hinton broth) as well as physiological (R10LB) media to determine the effect of vancomycin on USA100 strains. The study includes the profiling behavior of HA-MRSA USA100 D592 and D712 strains in the presence of vancomycin through various high-throughput assays. The US100 D592 and D712 strains were characterized at sub-inhibitory concentrations through growth curves, RNA sequencing, bacterial cytological profiling, and exo-metabolomics high throughput experiments.

Conclusions
The study reveals the vancomycin resistance behavior of HA-MRSA USA100 strains in dual media conditions using wide-ranging experiments.
Genome diversity in Ukraine
Authors: Oleksyk Taras K , Wolfsberger Walter W , Weber Alexandra M , Shchubelka Khrystyna , Oleksyk Olga T , Levchuk Olga , Patrus Alla , Lazar Nelya , Castro-Marquez Stephanie O , Hasynets Yaroslava , Boldyzhar Patricia , Neymet Mikhailo , Urbanovych Alina , Stakhovska Viktoriya , Malyar Kateryna , Chervyakova Svitlana , Podoroha Olena , Kovalchuk Natalia , Rodriguez-Flores Juan L , Zhou Weichen , Medley Sarah , Battistuzzi Fabia , Liu Ryan , Hou Yong , Chen Siru , Yang Huanming , Yeager Meredith , Dean Michael , Mills Ryan E , Smolanka Volodymyr 
Published: January 2021

Abstract

Background
The main goal of this collaborative effort is to provide genome-wide data for the previously underrepresented population in Eastern Europe, and to provide cross-validation of the data from genome sequences and genotypes of the same individuals acquired by different technologies. We collected 97 genome-grade DNA samples from consented individuals representing major regions of Ukraine that were consented for public data release. BGISEQ-500 sequence data and genotypes by an Illumina GWAS chip were cross-validated on multiple samples and additionally referenced to 1 sample that has been resequenced by Illumina NovaSeq6000 S4 at high coverage.

Results
The genome data have been searched for genomic variation represented in this population, and a number of variants have been reported: large structural variants, indels, copy number variations, single-nucletide polymorphisms, and microsatellites. To our knowledge, this study provides the largest to-date survey of genetic variation in Ukraine, creating a public reference resource aiming to provide data for medical research in a large understudied population.

Conclusions
Our results indicate that the genetic diversity of the Ukrainian population is uniquely shaped by evolutionary and demographic forces and cannot be ignored in future genetic and biomedical studies. These data will contribute a wealth of new information bringing forth a wealth of novel, endemic and medically related alleles.
Healthy settings: supported housing for people with mental and intellectual disabilities in Denmark
Authors: Nielsen Maj Britt Dahl , Mølbak Marie-Louise , Hvass Line Raahauge , Folker Anna Paldam 
Published: January 2021

Summary
Supported housing for people with mental and intellectual disabilities (IDs) is an important setting for health and may contribute positively and negatively to residents’ health. The aim of this study was to explore health promotion practices and services in supported housing in Denmark using a mixed-methods design comprising qualitative group interviews with managers and employees (n = 12) and a nationwide survey among managers (n = 276) and employees from supported housing facilities (n = 315). This study showed that employees tried to integrate health promotion in the daily work with residents, but efforts primarily focused on individual behavior and motivation. Findings points to several challenges and barriers, including ambivalent attitudes towards smoking and beliefs that health promotion undermines self-determination and empowerment. To build supportive environments for people with mental and IDs, we need to focus on the attitudes, values and competences of managers and employees to tackle misconceptions about smoking, raise awareness about the wider determinants and promote structural changes.
Genotype & phenotype in Lowe Syndrome: specificOCRL1patient mutations differentially impact cellular phenotypes
Authors: Ramadesikan Swetha , Skiba Lisette , Lee Jennifer , Madhivanan Kayalvizhi , Sarkar Daipayan , De La Fuente Agustina , Hanna Claudia B , Terashi Genki , Hazbun Tony , Kihara Daisuke , Aguilar R Claudio 
Published: January 2021

AbstractLowe Syndrome (LS) is a lethal genetic disorder caused by mutations in the OCRL1 gene which encodes the lipid 5′ phosphatase Ocrl1. Patients exhibit a characteristic triad of symptoms including eye, brain and kidney abnormalities with renal failure as the most common cause of premature death. Over 200 OCRL1 mutations have been identified in LS, but their specific impact on cellular processes is unknown. Despite observations of heterogeneity in patient symptom severity, there is little understanding of the correlation between genotype and its impact on phenotype.Here, we show that different mutations had diverse effects on protein localization and on triggering LS cellular phenotypes. In addition, some mutations affecting specific domains imparted unique characteristics to the resulting mutated protein. We also propose that certain mutations conformationally affect the 5′-phosphatase domain of the protein, resulting in loss of enzymatic activity and causing common and specific phenotypes (a conformational disease scenario).This study is the first to show the differential effect of patient 5′-phosphatase mutations on cellular phenotypes and introduces a conformational disease component in LS. This work provides a framework that explains symptom heterogeneity and can help stratify patients as well as to produce a more accurate prognosis depending on the nature and location of the mutation within the OCRL1 gene.
Fish consumption by great cormorants in Norwegian coastal waters—a human-wildlife conflict for wrasses, but not gadids
Authors: Dehnhard Nina , Langset Magdalene , Aglen Asgeir , Lorentsen Svein-Håkon , Anker-Nilssen Tycho 
Published: January 2021

Abstract
Piscivorous wildlife is often perceived as competitors by humans. Great cormorants of the continental subspecies (Phalacrocorax carbo sinensis) in the Baltic and North Sea increase, while local cod (Gadus morhua) stocks decline. In contrast, numbers of the Atlantic subspecies (Phalacrocorax carbo carbo), breeding along the Norwegian and Barents Seas, have been relatively stable. We investigated the diet of both great cormorant subspecies in breeding colonies along the Norwegian Coast from Lofoten to the Skagerrak and estimated the biomass of fish consumed annually by great cormorants in Norwegian waters. The birds’ consumption was compared with estimated fish stock sizes and fishery catches. Cod and saithe (Pollachius virens) dominated the diet in the Norwegian Sea and wrasses in the North Sea and Skagerrak. Estimated total fish consumption of cod and saithe by great cormorants was &lt;1.7% of estimated fish stocks and &lt;9% of that of human catches and therefore considered minor. Cormorant consumption of wrasses amounted to 110% of human catches. The practice of using wrasses as cleaner fish in the salmon farming industry leads to a conflict with cormorants, and we urge for a better understanding and management of wrasse populations, taking ecosystem functioning and natural predation into account.
Emergency pericardial drainage without aortic repair for type A intramural haematoma complicated by cardiac tamponade
Authors: Kitamura Tadashi , Miyaji Kagami 
Published: January 2021

Abstract
From April 2011 to March 2020, 87 patients with type A intramural haematoma and acute aortic dissection with thrombosed false lumen of the ascending aorta were treated at Kitasato University Hospital. The initial watch-and-wait strategy without emergency aortic repair was taken in 52 cases in which the maximum aortic diameter was ≤50 mm, pain score on arrival at our hospital was ≤3/10 on the numerical rating scale and there was no ulcer-like projection (ULP) in the ascending aorta. Eleven patients who fulfilled the criteria but developed cardiac tamponade underwent emergency pericardial drainage without aortic repair. Among these 11 patients, 3 patients developed an aortic event during the hospitalization; 1 patient developed enlargement of the ULP 18 days later but refused surgery, another patient developed rupture of the dissected brachiocephalic artery 4 days later and underwent emergency repair of the ascending aorta and the brachiocephalic artery and the other patient developed a new ULP in the ascending aorta 14 days later and underwent aortic repair. All 11 patients were discharged home. During follow-up (3.0 ± 2.4 years), 1 patient developed a recurrent type A acute aortic dissection and underwent emergency aortic repair 29 months later. There was no aorta-related death.
Complete sternal-sparing left ventricular assist device implantation is associated with improved postoperative mobility
Authors: Ayers Brian C , Bjelic Milica , Wood Katherine , Sheen Soun , Morrison Eric , Prasad Sunil , Gosev Igor 
Published: January 2021

Abstract
Left ventricular assist device (LVAD) implantation via a complete sternal-sparing (CSS) technique is gaining interest due to several potential benefits. We hypothesized that the CSS approach for HeartMate 3 (HM3) LVAD implantation improves postoperative mobility and physical independence compared to full sternotomy (FS). We retrospectively reviewed patients who were implanted with a commercial HM3 at our institution from September 2017 to August 2018. The Activity Measure for Post-Acute Care short forms and Functional Independence Measure scores were used to assess the patient’s physical limitations postoperatively. A total of 43 patients were included in the study: 27 (63%) CSS patients and 16 (37%) FS patients. At postoperative day 3, the CSS cohort demonstrated improved mobility based on Activity Measure for Post-Acute Care scores compared to the FS group; 40% of the CSS cohort versus 67% of the FS cohort remained 100% impaired. The CSS cohort also demonstrated greater postoperative independence in the Functional Independence Measure sit-to-stand metric with 78% of the CSS cohort achieving modified or complete independence by postoperative day 15 compared to only 21% of the FS patients. These early data suggest that the CSS approach for HM3 LVAD implantation improves postoperative mobility and functional independence compared to FS.
Endovascular aortic arch repair with a pre-cannulated double-fenestrated physician-modified stent graft: a benchtop experiment
Authors: Lounes Youcef , Chassin-Trubert Lucien , Gandet Thomas , Ozdemir Baris Ata , Peyron Antoine , Akodad Mariama , Alric Pierre , Canaud Ludovic 
Published: January 2021

Abstract

OBJECTIVES
The critical step in total endovascular aortic arch repair is to ensure alignment of fenestrations with, and thus maintenance of flow to, supra-aortic trunks. This experimental study evaluates the feasibility and accuracy of a double-fenestrated physician-modified endovascular graft [single common large fenestration for the brachiocephalic trunk and left common carotid artery and a distal small fenestration for left subclavian artery (LSA) with a preloaded guidewire for the LSA] for total endovascular aortic arch repair.

METHODS
Eight fresh human cadaveric thoracic aortas were harvested. Thoracic endografts with a physician-modified double fenestration were deployed for total endovascular aortic arch repair in a bench test model. A guidewire was preloaded through the distal fenestration for the LSA. All experiments were undertaken in a hybrid room under fluoroscopic guidance with subsequent angioscopy and open evaluation for assessment.

RESULTS
Mean aortic diameter in zone 0 was 31.3 ± 3.33 mm. Mean duration for stent graft modification was 20.1 ± 5.8 min. Mean duration of the procedure was 24 ± 8.6 min. The Medtronic Valiant Captivia stent graft was used in 6 and the Cook Alpha Zenith thoracic stent graft in 2 cases. LSA catheterization was technically successful with supra-aortic trunk patency in 100% of cases.

CONCLUSIONS
The use of a double-fenestrated stent graft with a preloaded guidewire appears to be a useful technical addition to facilitate easy and correct alignment of stent graft fenestrations with supra-aortic trunk origins.
Do Interviewers Affect Measures of Factual Political Knowledge? Evidence from Austria and Germany
Authors: Johann David , Mayer Sabrina J 
Published: January 2021

AbstractThis study examines how interviewers’ gender and education affect the measured level of factual political knowledge by drawing on competing theoretical frameworks: stereotype threat theory and interviewer noncompliance with the instructions. Testing these mechanisms using survey data from the Austrian National Election Study (AUTNES) and the German Longitudinal Election Study (GLES), we find no evidence for a stereotype threat effect, but seem to observe interviewer effects resulting from interviewer non-compliance. In Germany, respondents’ measured level of knowledge was significantly higher when a male interviewer, regardless of his education, conducted the interview, compared with low educated female interviewers. This finding has implications for survey-based studies, which measure factual political knowledge, for example attempts to limit such effects should be made during the interviewer briefing.
Compressed Sensing with 1D Total Variation: Breaking Sample Complexity Barriers via Non-Uniform Recovery
Authors: Genzel Martin , März Maximilian , Seidel Robert 
Published: January 2021

AbstractThis paper investigates total variation minimization in one spatial dimension for the recovery of gradient-sparse signals from undersampled Gaussian measurements. Recently established bounds for the required sampling rate state that uniform recovery of all $s$-gradient-sparse signals in ${\mathbb{R}}^n$ is only possible with $m \gtrsim \sqrt{s n} \cdot{\operatorname{PolyLog}}(n)$ measurements. Such a condition is especially prohibitive for high-dimensional problems, where $s$ is much smaller than $n$. However, previous empirical findings seem to indicate that this sampling rate does not reflect the typical behavior of total variation minimization. The present work provides a rigorous analysis that breaks the $\sqrt{s n}$-bottleneck for a large class of “natural” signals. The main result shows that non-uniform recovery succeeds with high probability for $m \gtrsim s \cdot{\operatorname{PolyLog}}(n)$ measurements if the jump discontinuities of the signal vector are sufficiently well separated. In particular, this guarantee allows for signals arising from a discretization of piecewise constant functions defined on an interval. The key ingredient of the proof is a novel upper bound for the associated conic Gaussian mean width, which is based on a signal-dependent, non-dyadic Haar wavelet transform. Furthermore, a natural extension to stable and robust recovery is addressed.
Feasibility and Performance of Self-Collected Nasal Swabs for Detection of Influenza Virus, Respiratory Syncytial Virus, and Human Metapneumovirus
Authors: Suntarattiwong Piyarat , Mott Joshua A , Mohanty Sarita , Sinthuwattanawibool Chalinthorn , Srisantiroj Nattinee , Patamasingh Na Ayudhaya Orada , Klungthong Chonticha , Fernandez Stefan , Kim Lindsay , Hunt Danielle , Hombroek Danielle , Brummer Tana , Chotpitayasunondh Tawee , Dawood Fatimah S , Kittikraisak Wanitchaya ,   PRIME Study Group, Kaoaien Surasak , Phadungkiatwatana Podjanee , Asavapiriyanont Suvanna , Tomyabatra Krissada , Rawanban Boonsong , Ellison Damon 
Published: January 2021

Abstract

Background
We assessed performance of participant-collected midturbinate nasal swabs compared to study staff-collected midturbinate nasal swabs for the detection of respiratory viruses among pregnant women in Bangkok, Thailand.

Methods
We enrolled pregnant women aged ≥18 years and followed them throughout the 2018 influenza season. Women with acute respiratory illness self-collected midturbinate nasal swabs at home for influenza viruses, respiratory syncytial viruses (RSV), and human metapneumoviruses (hMPV) real-time RT-PCR testing and the study nurse collected a second midturbinate nasal swab during home visits. Paired specimens were processed and tested on the same day.

Results
The majority (109, 60%) of 182 participants were 20–30 years old. All 200 paired swabs had optimal specimen quality. The median time from symptom onsets to participant-collected swabs was 2 days and to staff-collected swabs was also 2 days. The median time interval between the 2 swabs was 2 hours. Compared to staff-collected swabs, the participant-collected swabs were 93% sensitive and 99% specific for influenza virus detection, 94% sensitive and 99% specific for RSV detection, and 100% sensitive and 100% specific for hMPV detection.

Conclusions
Participant-collected midturbinate nasal swabs were a valid alternative approach for laboratory confirmation of influenza-, RSV-, and hMPV-associated illnesses among pregnant women in a community setting.
Integrating crop growth models with remote sensing for predicting biomass yield of sorghum
Authors: Yang Kai-Wei , Chapman Scott , Carpenter Neal , Hammer Graeme , McLean Greg , Zheng Bangyou , Chen Yuhao , Delp Edward , Masjedi Ali , Crawford Melba , Ebert David , Habib Ayman , Thompson Addie , Weil Clifford , Tuinstra Mitchell R 
Published: January 2021

Abstract
Plant phenotypes are often descriptive, rather than predictive of crop performance. As a result, extensive testing is required in plant breeding programmes to develop varieties aimed at performance in the target environments. Crop models can improve this testing regime by providing a predictive framework to (i) augment field phenotyping data and derive hard-to-measure phenotypes and (ii) estimate performance across geographical regions using historical weather data. The goal of this study was to parameterize the Agricultural Production Systems sIMulator (APSIM) crop growth models with remote-sensing and ground-reference data to predict variation in phenology and yield-related traits in 18 commercial grain and biomass sorghum hybrids. Genotype parameters for each hybrid were estimated using remote-sensing measurements combined with manual phenotyping in West Lafayette, IN, in 2018. The models were validated in hybrid performance trials in two additional seasons at that site and against yield trials conducted in Bushland, TX, between 2001 and 2018. These trials demonstrated that (i) maximum plant height, final dry biomass and radiation use efficiency (RUE) of photoperiod-sensitive and -insensitive forage sorghum hybrids tended to be higher than observed in grain sorghum, (ii) photoperiod-sensitive sorghum hybrids exhibited greater biomass production in longer growing environments and (iii) the parameterized and validated models perform well in above-ground biomass simulations across years and locations. Crop growth models that integrate remote-sensing data offer an efficient approach to parameterize larger plant breeding populations.
The value of federated learning during and post-COVID-19
Authors: Qian Feng , Zhang Andrew 
Published: January 2021

Abstract
Federated learning (FL) as a distributed machine learning (ML) technique has lately attracted increasing attention of healthcare stakeholders as FL is perceived as a promising decentralized approach to address data privacy and security concerns. The FL approach stores and maintains the privacy-sensitive data locally while allows multiple sites to train ML models collaboratively. We aim to describe the most recent real-world cases using the FL in both COVID-19 and non-COVID-19 scenarios and also highlight current limitations and practical challenges of FL.
The Recognition Dilemma: Negotiating Identity in the Israeli–Palestinian Conflict
Authors: Freedman Joshua 
Published: January 2021

AbstractDuring five years of US-sponsored Israeli–Palestinian peace talks (2009–2014), Israeli PM Netanyahu repeatedly demanded that Palestinians recognize Israel as a Jewish state as part of any final status agreement. Simultaneously, a chorus of Israeli political and military elites consistently challenged this negotiating posture as a threat to the state's very identity. What explains these competing positions on recognition's absence and necessity? Considerable attention in IR has recently focused on the lengths states go to correct acts of misrecognition, out of a genuine need for recognition, and the self-certainty recognition provides in a socially uncertain world. This structural and intrinsic model neglects, however, the powerful role agents can play in constructing, or avoiding, recognition conflict. Political considerations can cause recognition, and its absence, to matter more than it otherwise should, just as they can cause others to view recognition campaigns as vulnerable and ontologically harmful pursuits. This article proposes both an instrumental model of recognition and a theory on the recognition dilemma needed to explain these competing attitudes. In doing so, it shifts attention away from social structure, and relations, in order to take domestic processes seriously as a forum for both the construction and contestation of recognition politics.