bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating the Aerodynamic Coefficients of a Savonius Rotor Blade Profile Developed Through the Simplex Search Method
Authors: Mohan Man , Kansagara Divyeshkumar D. , Sharma Deepak , Saha Ujjwal K. 
Published: December 2021

Abstract
The Savonius rotor, a type of vertical-axis wind turbine, seems to be promising for small-scale power generation. Most of the studies conducted so far have focused on the evaluation of torque and power coefficients (CT, CP) of the rotor. This paper aims at analyzing the aerodynamic drag and lift coefficients (CD, CL) of a Savonius rotor blade profile that is generated by the simplex search method to maximize its CP. The optimization is carried out by coupling the numerical simulations with the simplex search method. The optimized blade profile thus obtained is symmetric about its axis, where one half is created through a natural cubic spline curve using three points. Two-dimensional (2D) unsteady numerical simulations have been conducted by adopting ANSYS FLUENT solver to examine the CD and CL of the optimized blade profile at an inlet air velocity of 7.30 m/s. The shear stress transport (SST) k-ω turbulence model is used to solve the transient Reynolds-averaged Navier-Stokes (RANS) equations. The aerodynamic analysis is performed over a range of tip speed ratios (TSRs). The total pressure, velocity magnitudes, and the turbulent intensity contours of the optimized blade profile are generated and studied at different angles of rotation. The CD and CL of the blade profile are investigated for a complete rotation with an increment of 1°. At TSR = 0.8, the optimized profile shows a CDmax of 1.91 at an angle of rotation of 54°, while CDmin is found to be 0.45 at an angle 147°.
A Parametric Study on the Effect of Casing Treatment Slots on Performance Enhancement of a Single Stage Axial Flow Compressor
Authors: Amin Gautham A. , Salunkhe Pramod B. , Kini Chandrakanth R. 
Published: December 2021

Abstract
This paper numerically investigates the effect of slots on the performance of a highly subsonic axial flow compressor. The axial flow compressor consisting of 21 rotor blades with NACA 65 series blade profile was used for the simulations. The present results were obtained using different turbulence models and shear stress transport model was found to be the best one. Studies were conducted to determine the influence of length, depth and skew angle of the slot on the compressor performance. The slot width and centre-to-centre distance between the successive slots were maintained at 6.3% Ca and 11% Ca, respectively. The present study was carried out at different slot lengths (0 to 100% of axial chord, 20 to 100% of axial chord and 40 to 100% of axial chord), slot depths (7.9, 11 and 15.7% Ca) and skew angles (0°, 30°, 45° and 60°). The slot length of 20 to 100% of Ca, depth of 15.7% Ca and skew angle of 60° resulted in the best compressor performance leading to 22.1% stall margin improvement. Subsequently, flow characteristics were studied without and with slots.
Theoretical Estimation of Minimum and Maximum Allowable Rotational Speed of Supercritical CO2 Inward Flow Radial Turbine
Authors: Hoque Syed J. , Kumar Pramod 
Published: December 2021

Abstract
Supercritical CO2 inward flow radial turbines necessitate high operating speeds due to the high density of sCO2, especially in sub-MW scale power generation where rotational speeds can be in the range of 50k to 150k rpm. Although designing the turbine at these high rotational speeds is reasonable from the aerodynamic efficiency point of view but generally not practical to operate. A theoretical framework based on 1-D meanline analysis is built to evaluate the minimum and maximum rotational speed limits corresponding to a set of boundary conditions and operating constraints. The results show that minimum allowable speed depends on the inlet velocity triangle (IVT) and is constrained by inlet Mach number, inlet blade height, and inlet flow angle. On the other hand, maximum allowable speed depends on the outlet velocity triangle (OVT) and is constrained by outlet relative Mach number, outlet hub radius, and blade speed. The theoretical models are demonstrated from kilowatt to megawatt power levels, and the results are compared with commercial software and Balje’s Ns-Ds diagram. Although this study is highlighted in the context of supercritical CO2 as the working fluid, in principle, the same models are equally valid for any working fluid.
Noncircular Chainrings Do Not Influence Physiological Responses During Submaximal Cycling
Authors: Leong Chee-Hoi , Elmer Steven J. , Martin James C. 
Published: December 2021

Pedal speed and mechanical power output account for 99% of metabolic cost during submaximal cycling. Noncircular chainrings can alter instantaneous crank angular velocity and thereby pedal speed. Reducing pedal speed during the portion of the cycle in which most power is produced could reduce metabolic cost and increase metabolic efficiency.Purpose:To determine the separate contributions of pedal speed and chainring shape/eccentricity to the metabolic cost of producing power and evaluate joint-specific kinematics and kinetics during submaximal cycling across 3 chainring eccentricities (CON = 1.0; LOW = 1.13; HIGH = 1.24).Methods:Eight cyclists performed submaximal cycling at power outputs eliciting 30%, 60%, and 90% of their individual lactate threshold at pedaling rates of 80 rpm under each chainring condition (CON80rpm; LOW80rpm; HIGH80rpm) and at pedaling rates for the CON chainring chosen to match pedal speeds of the noncircular chainrings (CON78rpmto LOW80rpm; CON75rpmto HIGH80rpm). Physiological measures, metabolic cost, and gross efficiency were determined by indirect calorimetry. Pedal and joint-specific powers were determined using pedal forces and limb kinematics.Results:Physiological and metabolic measures were not influenced by eccentricity and pedal speed (allPs > .05). Angular velocities produced during knee and hip extension were lower with the HIGH80rpmcondition compared with the CON80rpmcondition (allPs < .05), while angular velocity produced during ankle plantar flexion remained unchanged.Conclusions:Despite the noncircular chainrings imposing their eccentricity on joint angular kinematics, they did not reduce metabolic cost or increase gross efficiency. Our results suggest that noncircular chainrings neither improve nor compromise submaximal cycling performance in trained cyclists.
The importance of oxbow lakes in the floodplain storage of pollutants
Authors: Thomas Summer-Solstice , Constantine José Antonio , Dethier David , Thoman John W. , Racela Jason , Blau Emmett , Landis Joshua D. 
Published: December 2021

Abstract
Oxbow lakes are important stores for fine-grained sediment, which potentially makes them critical sinks for sediment-associated pollutants. We leverage an exhaustive public archive of coring data, supplemented by our data collection, to provide a quantitative assessment of the role of oxbows as off-channel sinks. We investigated loading trends of sediment-sorbed polychlorinated biphenyls (PCBs) within oxbows of the Housatonic River, an actively meandering river in western Massachusetts, USA. Our results reveal the efficiency of oxbows as sinks, with average PCB concentrations (14.8 ppm) that are nearly twice that of the surrounding floodplain (7.56 ppm). Even though the 5.83 km2 floodplain is the largest sink of PCB-laden material, storing as much as 14.1 t of PCBs or 2.42 g m−2, oxbows store more than 20% of all PCBs (3.63 t of PCBs or 11.2 g m−2) while making up just over 5% of the floodplain surface area. Nearly 85% of the oxbow storage of PCBs occurs within the first 50 m of floodplain, making clear the significance of regular oxbow production to the off-channel storage of sediment-associated pollutants.
Biphenyl Hydrogenation with Syngas for Hydrogen Purification and Transportation: Performance of Dispersed Catalytic Systems Based on Transition Metal Sulfides
Authors: Baigildin I. G. , Karakhanov E. A. , Maximov A. L. , Vutolkina A. V. 
Published: December 2021

Abstract
The feasibility of biphenyl hydrogenation with syngas for hydrogen
purification and binding with the aim of its transportation was demonstrated.
Specific features of the hydrogenation of biphenyl as a promising organic
hydrogen carrier using unsupported Ni–Mo sulfide catalysts were studied. In
particular, the influence of temperature, reaction time, presence of water in
the system, and Н2/СО gas mixture composition on the
substrate conversion and selectivity with respect to products was examined. The
highest conversion and the maximal hydrogen uptake are reached at 380°С in 6–8
h. The dispersed catalysts are active in biphenyl hydrogenation at the CO
concentration in the Н2/СО gas mixture of up to 50 vol %,
and H2O can act in this case as an in situ hydrogen
source owing to the occurrence of the water-gas shift reaction.
Mental health and implications for antiretroviral adherence in a multiethnic Asian cohort
Authors: Dhaliwal Jaspal Singh , Chan Lai Gwen , Goh Justine Chay Boon , Koh Karis Hui En , Wong Chen Seong 
Published: December 2021

ObjectivesResearch suggests a high prevalence of depression and anxiety in people living with HIV, resulting in negative health outcomes and poorer help-seeking behaviours when undetected. Subsequent disease progression and non-adherence to treatment constitute a significant barrier to HIV treatment. This paper aims to identify the risk factors for the development of psychological distress and non-adherence to antiretroviral medication in people living with HIV.MethodsAn HIV outpatient clinical service screened for anxiety and depressive symptoms. As part of a retrospective analysis of the cohort, independent sample t-test and χ2test were conducted to examine differences between symptomatic and asymptomatic patients in demographic variables such as mode of transmission and disclosure to family; clinical indicators such as psychiatric history and history of alcohol and substance use; and outcome variables such as current psychological distress and non-adherence. Binary logistic regression was conducted to determine predictors of psychological distress and non-adherence.ResultsAfter adjusting for age, no history of alcohol use and psychiatric history were found to be significant risk factors for psychological distress during the programme. Older patients were less likely to be symptomatic during the programme. After adjusting for age, having received intervention and psychiatric history, significant risk factors for non-adherence to antiretroviral medication were mode of transmission, history of smoking and being symptomatic during the programme.ConclusionSignificant psychological distress occurring early in HIV care predicts future non-adherence to antiretroviral treatment, highlighting the importance of early detection and intervention for psychological distress in people living with HIV. Mental health interventions should be intercalated with treatment adherence interventions to improve HIV treatment outcomes.
Model of black hole and white hole in Minkowski spacetime
Authors: Yu-Zhu Chen , Yu-Jie Chen , Shi-Lin Li , Fu-Lin Zhang , Wu-Sheng Dai 
Published: December 2021

AbstractIn this paper, we construct toy models of the black hole and the white hole by setting proper boundaries in the Minkowski spacetime, according to the modern definition. We calculate the thermal effect of the black hole with the tunneling mechanism. We consider the role of boundary conditions at the singularity and on the horizon. In addition, we show that the white hole possesses a thermal absorption.
Demonstration of using HF-etchant mixed into CO2 to lift-off thin-film GaAs layers by supercritical fluid technology
Authors: Feng David Jui-Yang , Kuo Heng , Yang Cheng-Fu 
Published: December 2021

The epitaxial lift-off (ELO) process based on selectively etching a thin sacrificial AlAs layer from GaAs substrate was performed using high-concentrated aqueous hydrofluoric (HF) etchant. However, because of using the wet etching method, the traditional ELO process has many drawbacks and limitations. Supercritical fluids (SCFs) naturally have the characteristics of low viscosity, high diffusivity, and zero surface tension. Therefore, the development of a gas-phase-like dry etching method based on mixing HF into CO2 and operating the mixture of HF/CO2 in SCFs condition as etchant is hereby proposed to overcome those bottlenecks existing in traditional wet ELO processes. However, there are no available experimental results for etching AlAs layers by HF in SCFs yet. Therefore, a HF-compatible corrosion-resistant high-pressure system was designed and built up to perform the idea. The capabilities of etching sample in supercritical CO2 (scCO[Formula: see text] had been systemically investigated under various pressures (2000–3000 psi) and temperatures (40–60[Formula: see text]C). Besides, the etching performances separately conducted by using aqueous-HF and anhydrous HF/Pyridine as the source etchant and mixing with scCO2 at a fixed temperature, pressure and etching time were also examined and compared under different equivalent HF concentrations. An evaluation of using acetone as the co-solvent mixed with HF/scCO2 mixture for enhancing the etch rate in different volume ratio of HF/co-solvent was further investigated and discussed. With this system, we demonstrate releasing a size of [Formula: see text] ([Formula: see text]) and 3 [Formula: see text]m-thick free-standing GaAs sheet from a 150 nm AlAs sacrificial layer by the etching sample in HF/scCO2 mixture. The released GaAs sheet was also successfully transferred to a flexible PET substrate by using a PDMS stamp and an adhesive layer of NOA61.
Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic?
Authors: Erickson Emily C. , Toker Alex 
Published: December 2021

Abstract
The high frequency of PI3K pathway alterations in cancer has motivated numerous efforts to develop drugs targeting this network. Although many potent and selective inhibitors have been developed and evaluated in preclinical models, their progress to clinical approval has been limited. Here we discuss the pressing need to develop improved biomarker strategies to guide patient selection and improve assessment of patient responses to PI3K pathway inhibitors to address unresolved issues surrounding the efficacy and tolerability of these compounds in patients with cancer.
Macrophage-Targeting by CSF1/1R Blockade in Pancreatic Cancers
Authors: Ho Won Jin , Jaffee Elizabeth M. 
Published: December 2021

Abstract
Published in Cancer Research in 2014, Zhu and colleagues achieved a mechanistic leap in our understanding of cancer-associated macrophage biology with their proof-of-concept study showing that macrophage-specific targeting, via blocking colony-stimulating factor–1 (CSF1) signaling through its cognate receptor CSF1R, synergized with checkpoint immunotherapy to enhance antitumor immunity in mouse models of pancreatic cancer. Here, we reflect on the critical set of observations presented in this study and how the study's findings fueled the subsequent efforts to translate CSF1/1R-specific and other tumor-associated macrophage modulating therapies into the clinic.
See related article by Zhu and colleagues, Cancer Res 2014;74:5057–5069.
How Compensatory Mechanisms and Adaptive Rewiring Have Shaped Our Understanding of Therapeutic Resistance in Cancer
Authors: Bergholz Johann S. , Zhao Jean J. 
Published: December 2021

Abstract
Therapeutic resistance to targeted therapies by tumor cells is a common and serious problem in the clinic. Increased understanding of the molecular mechanisms that underly resistance is necessary for the rational design and improvement of effective pharmacologic treatment strategies. The landmark study by O'Reilly and colleagues published in Cancer Research in 2006 provided valuable insights into nongenomic adaptive rewiring and compensatory mechanisms responsible for mediating resistance to targeted inhibition of the PI3K–AKT–mTOR pathway, and how tumor cells regulate signaling pathways via negative feedback loops. These findings have proven fundamental for guiding current efforts to develop effective combination treatments and provided a blueprint for research studies aimed at understanding the intricacies of cellular signaling.
See related article by O'Reilly and colleagues, Cancer Res 2006;66:1500–8
Uncovering Tumorigenesis Circuitry with Combinatorial CRISPR
Authors: Fong Samson H. , Munson Brenton P. , Ideker Trey 
Published: December 2021

Abstract
Oncogenesis relies on the alteration of multiple driver genes, but precisely which groups of alterations lead to cancer is not well understood. To chart these combinations, Zhao and colleagues use the CRISPR-Cas9 system to knockout all pairwise combinations among 52 tumor suppressor genes, with the goal of identifying groups of alterations that collaborate to promote cell growth. Interaction screens are performed across multiple models of tumorigenesis in cell cultures and mice, revealing clear cooperation among NF2, PTEN, and TP53 in multiple models. These and other strongly synergistic interactions are characterized further by single-cell transcriptomic profiling. This methodology presents a scalable approach to move beyond single-gene drivers to map the complex gene networks that give rise to tumorigenesis.
See related article by Zhao et al., p. 6090
Kept in the Family: Remarriage, Siblings, and Consanguinity in the
Netherlands
Authors: van Dijk Ingrid K. , Kok Jan 
Published: December 2021

Abstract
Widowhood involves many practical challenges next to the emotional impact of bereavement. Remarriage to a blood relative of a deceased spouse can often help a bereaved spouse to solve issues related to inheritance, child care, and comfort in a stressful period. A study of 15,540 widowers and 18,837 widows in the Dutch province of Zeeland—of whom about 8,000 men and 5,000 women eventually remarried—which uses genealogical data about their partners and the links family-reconstitution database, finds that the relatively high likelihood of farmers’ widows remarrying and doing so with kin may have been a strategy to prevent property from falling into the hands of other families. Notwithstanding that the attractiveness of a widow or widower could also be a factor in opportunities to remarry, older widows and widows with many young children, whose chances on the remarriage market tended to be poor, did not usually have such recourse to kin in remarriage.
An Early Power-Sharing Regime: The Alternativa System in Spanish Colonial America
Authors: Schwartz Daniel 
Published: December 2021

Abstract
The alternativa system in Spanish American religious orders was an early example of deliberate electoral engineering to address the problem of social division. It was subject to criticism, however, for stealing voters’ freedom, ignoring the rights of candidates, and restricting access to competent officeholders. Moreover, it often gave disproportionate power to a minority faction. Hence, the alternativa remained, at best, an expedient, short-term solution to the problem of factionalism. Examining the canonists’ debate about the alternativa is instructive because it reveals the darker moral side of power-sharing regimes whenever and wherever they occur.
Introduction
Authors: Ménard Anaïs , Bedert Maarten 
Published: December 2021

Abstract
This section introduction explores the imaginative dimension of mobility in two West African countries, Sierra Leone and Liberia. Building on literature that highlights the existential dimension of movement and migration, the authors explore three socio-cultural patterns that inform representations of im/mobility: historical continuities and the longue-durée perspective on mobile practices, the association of geographical mobility with social betterment, and the interaction between local aspirations and the imaginary of global modernity. The three individual contributions by Bedert, Enria and Ménard bring out the work of imagination attached to im/mobility both in ‘home’ countries and diaspora communities, and underline the continuity of representations and practices between spaces that are part of specific transnational social fields.
The Kitāb al-ʿIlm of al-Bukhārī: A Handbook on Knowledge
Authors: Samba Campos Estrella 
Published: December 2021

Abstract
The Kitāb al-ʿIlm of al-Bukhārī (d. 256/870), positioned at the beginning of his Ṣaḥīḥ, represents an innovative turn in terms of structural arrangement and thematic discourse within the context of “books” and narratives on knowledge (ʿilm). Al-Bukhārī’s construction of ʿilm differs from preceding discussions and reveals a unique portrayal. I suggest that the early interdependence between ʿilm-ḥadīth and adab conveyed by al-Bukhārī echoes the Kitab al-Adab written by his teacher, Ibn Abī Shayba (d. 235/849). In light of understanding this intertextual dynamic, I will compare earlier ʿilm narratives with particular themes introduced by al-Bukhārī. Similarly, I will discuss how the early correlation between knowledge and education helped motivate his authorial intent, concluding that the Kitāb al-ʿIlm represents an original, technical and pedagogical work of taḥammul al-ʿilm, the actual practice of teaching knowledge.
Influence of the Ural High on Air Temperatures over Eastern Europe and Northern China during Extended Winter
Authors: Sui Cuijuan , Karpechko Alexey Yu. , Vihma Timo , Yu Lejiang , Feng Licheng 
Published: December 2021

Abstract
The anticyclonic anomaly over the Ural Mountains, or the Ural high (UH), has recently received much attention as a factor related to weather anomalies across Eurasia. Here we studied how the UH affects the occurrence of cold wintertime episodes over eastern Europe and northern China. By employing three methods to identify the UH, we found that a method based on the sea level pressure anomaly captures a stronger cooling signal over eastern Europe and this method includes nonblocking cases associated with low-level anticyclones that do not affect the upper troposphere. However, with UH occurrence, a stronger cooling over northern China is detected by a method based on 500-hPa geopotential height fields. Cold events over eastern Europe typically occur when UH formation is associated with a Rossby wave breaking in the upper level. Our results show that the horizontal temperature advection plays an important role in formation of cold episodes in both eastern Europe and northern China. The advection is balanced by diabatic processes, which show an opposite sign to the temperature advection in both regions. Also adiabatic warming contributes to balancing the advection in northern China. We find that the exact location of the positive SLP anomaly during UH episodes is the most important factor controlling whether or not eastern Europe or northern China will experience a cold episode. If the positive SLP anomaly develops more northwest than usual, eastern Europe will experience a cold episode. When the anomaly moves eastward, northern China will be cold.