bluuebunny/crossref_metadata_2025_split huggingface dataset:
Good Tumor Response to Chemoradioimmunotherapy in dMMR/MSI-H Advanced Colorectal Cancer: A Case Series
Authors: Zhou Chengjing , Jiang Ting , Xiao Yajie , Wang Qiaoxuan , Zeng Zhifan , Cai Peiqiang , Zhao Yongtian , Zhao Zhikun , Wu Dongfang , Lin Hanqing , Sun Chao , Zhang Rong , Xiao Weiwei , Gao Yuanhong 
Published: December 2021

PurposeImmune checkpoint blockade has led to a significant improvement of patient survival in metastatic colorectal cancer (CRC) with DNA mismatch repair-deficiency (dMMR)/microsatellite instability-high (MSI-H). However, not all these patients are sensitive to monoimmunotherapy. We firstly presented a case series of advanced dMMR/MSI-H CRCs treating with PD-1 inhibitor-based chemoradioimmunotherapy (CRIT).Methods and MaterialsWe assessed the short-term efficacy and safety of CRIT in advanced dMMR/MSI-H CRCs, and also did next-generation sequencing (NGS) assays.ResultsOur analysis included five advanced dMMR/MSI-H CRCs who have received toripalimab-based CRIT. Toripalimab was given 240mg every three weeks, and the radiation dose was 45-50 gray in 25 fractions. Chemotherapy regimens consisted of CAPOX in three patients, capecitabine in one patient, and mFOLFOX6 in one patient. Initially, two patients displayed complete response (CR), and three patients achieved partial response (PR) on imaging findings. Afterwards, one PR patient was confirmed pathological complete response after surgery, leading to three CR cases in total. Hematological toxicity was the most common adverse effect, and only two patients developed mild immune-related adverse effects besides. All the treatment-related adverse events were under control. Based on the NGS results, the median intratumor heterogeneity was 0.19 (range 0-0.957), which was less in CR patients than PR patients (P = 0.019). Genetic mutations at DNA damage repair genes and the JAK1 gene were also observed.ConclusionsFor advanced dMMR/MSI-H CRC, anti-PD-1 based CRIT is effective and safe. Further studies are required to better clarify the potential role and mechanism of CRIT as a viable therapeutic strategy in this population.
Based on Network Pharmacology Tools to Investigate the Mechanism of Tripterygium wilfordii Against IgA Nephropathy
Authors: Xia Ming , Liu Di , Liu Haiyang , Zhao Juanyong , Tang Chengyuan , Chen Guochun , Liu Yu , Liu Hong 
Published: December 2021

Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease and poses a global major public health burden. The preparation of Tripterygium wilfordii Hook F (TwHF) is widely applied for treating patients with Immunoglobulin A nephropathy in China, while the molecular mechanisms remain unclear. This study aimed to verify the therapeutic mechanism of TwHF on IgAN by undertaking a holistic network pharmacology strategy in combination with in vitro and in vivo experiments.Methods: TwHF active ingredients and their targets were obtained via the Traditional Chinese Medicine Systems Pharmacology Database. The collection of IgAN-related target genes was collected from GeneCards and OMIM. TwHF-IgAN common targets were integrated and visualized by Cytoscape. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to determine the predominant molecular mechanisms and pathways of TwHF on the treatment of IgAN. The protein-protein interaction network was constructed by the STRING online search tool, and hub genes were identified using R software. The expression of hub gene and related signaling were evaluated in TwHF-treated mice through immunohistochemistry and western blot and further validated in human mesangial cells (HMCs). In addition, Cell counting kit 8 (CCK8) and flow cytometry were used to detect the effects of TwHF on cell proliferation and cell cycle of mesangial cells.Results: A total of 51 active ingredients were screened from TwHF and 61 overlapping targets related to IgAN were considered potential therapeutic targets, GO functions and KEGG analyses demonstrated that these genes were primarily associated with DNA-binding transcription factor binding, lipid and atherosclerosis pathway. Genes with higher degrees including AKT1, CXCL8, MMP9, PTGS2, CASP3, JUN are hub genes of TwHF against IgAN. Verification of hub gene JUN both in vitro and in vivo showed that TwHF significantly attenuated JUN phosphorylation in the kidneys of IgAN mice and aIgA1-activated HMCs, meanwhile suppressing HMCs proliferation and arresting G1-S cell cycle progression.Conclusion: Our research strengthened the mechanisms of TwHF in treating IgAN, inhibition of JUN activation may play a pivotal role in TwHF in alleviating IgAN renal injury.
Prognostic Factors and Clinical Characteristics of Duodenal Adenocarcinoma With Survival: A Retrospective Study
Authors: Sun Huapeng , Liu Yi , Lv Long , Li Jingwen , Liao Xiaofeng , Gong Wei 
Published: December 2021

BackgroundTo evaluate the clinical risk factors that influence the overall survival in patients with duodenal adenocarcinoma (DA) after tumor resection.MethodsThis study retrospectively analyzed 188 patients who underwent tumor resection for DA between January 2005 and June 2020 at Xiangyang Central Hospital.ResultsThe median survival of the patients who underwent resectional operation was 54 months, longer than of those who underwent palliative surgery (20.8 months) (2,916.17; 95% CI, 916.3−9,280.5; p &lt; 0.001). Survival of non-ampullary duodenal carcinoma patients (50.3 months; 95% CI, 39.7−61.8) was similar to that of ampullary duodenal carcinoma patients (59.3 months; 95% CI, 38.6−66.7) but was significantly better than that of papillary adenocarcinoma patients (38.9 months; 95% CI, 29.8−54.8; p = 0.386). Those with intestinal-type ductal adenocarcinomas had a longer median overall survival than those with the gastric type (61.8 vs. 46.7 months; p &lt; 0.01) or pancreatic type (32.2 months; p &lt; 0.001). Clinical DA samples had significantly diverse expressions of ATG12, IRS2, and IGF2. Higher expressions of the ATG12 and IRS2 proteins were significantly correlated with worse survival. Multivariate Cox regression analysis revealed that lymph node metastasis (hazard ratio (HR), 6.44; 95% CI, 3.68−11.27; p &lt; 0.0001), margin status (HR, 4.94; 95% CI, 2.85−8.54; p &lt; 0.0001), and high expression of ATG12 (HR, 1.89; 95% CI, 1.17−3.06; p = 0.0099) were independent prognostic factors negatively associated with survival in patients undergoing curative resection. There was no survival difference between the groups with ampullary, non-ampullary, and papillary adenocarcinomas treated with adjuvant chemotherapy (p = 0.973).ConclusionGastric/pancreatic type, high expression of ATG12, lymph node metastases, and margin status were negative prognosticators of survival in patients with DAs than in those with tumor anatomical location. Curative resection is the best treatment option for appropriate patients.
Quantitative Analysis and Visualization of the Interaction Between Intestinal Microbiota and Type 1 Diabetes in Children Based on Multi-Databases
Authors: Zhao Mingyi , Xu Shaokang , Cavagnaro María José , Zhang Wei , Shi Jian 
Published: December 2021

Background: As an important autoimmune disease, type 1 diabetes (T1D) is often diagnosed in children, but due to the complexity of the etiology of diabetes and many other factors, the disease pathogenesis of diabetes is still unclear. The intestinal microbiota has been proved to have close relationships with T1D in recent years, which is one of the most important molecular bases of pathogenesis and prognosis factors for T1D. Using the multi-omics and multicenter sample analysis method, a number of intestinal microbiota in T1D have been discovered and explained, which has provided comprehensive and rich information. However, how to find more useful information and get an intuitive understanding that people need conveniently in the huge data sea has become the focus of attention. Therefore, quantitative analysis and visualization of the interaction between intestinal microbiota and T1D in children are urgently needed.Methods: We retrieved the detailed original data from the National Center for Biotechnology Information, GMREPO, and gutMEGA databases and other authoritative multiple projects with related research; the ranking of intestinal microbiota abundance from healthy people, overall T1D patients, and T1D in children (0–18 years old) were detailed analyzed, classified, and visualized.Results: A total of 515 bacterial species and 161 related genera were fully analyzed. Also, Prevotella copri was led by 21.25% average abundance, followed by Clostridium tertium of 10.39% in all-cross T1D patients. For children with T1D, Bacteroides vulgatus has high abundance in all age periods, whereas the abundance of each intestinal microbiota was more uniform in female samples, with the ranking from high to low as Bacteroides dorei 9.56%, P. copri 9.53%, Streptococcus pasteurianus 8.15%, and C. tertium 7.53%, whereas in male samples, P. copri was accounted for the largest by 22.72%. The interaction between intestinal microbiota and comparison between healthy people and children with T1D was also detailed analyzed.Conclusions: This study provides a new method and comprehensive perspectives for the evaluation of the interaction between intestinal microbiota and T1D in children. A set of useful information of intestinal microbiota with its internal interaction and connections has been presented, which could be a compact, immediate, and practical scientific reference for further molecular biological and clinical translational research of T1D in children.
Effectiveness of a Malaysian Media Intervention Workshop: Safe Reporting on Suicide
Authors: Lim Jane Tze Yn , Cheng Qijin , Ng Yin Ping , Pheh Kai Shuen , Panirselvam Ravivarma Rao , Tay Kok Wai , Lim Joanne Bee Yin , Chan Wen Li , Amer Nordin Amer Siddiq , Zakaria Hazli , Bartlett Sara , Skehan Jaelea , Chen Ying-Yeh , Yip Paul Siu Fai , Shah Shamsul Azhar , Chan Lai Fong 
Published: December 2021

Background:Suicide remains an important cause of premature deaths and draws much media attention. However, unsafe reporting and portrayal of suicides by the media have been associated with increased risk of suicidal behavior. Current evidence suggests that media capacity-building could potentially prevent suicide. However, there are still knowledge gaps in terms of a lack of data on effective strategies for improving awareness and safe reporting of suicide-related media content. This study aims to investigate the effectiveness of a workshop conducted with members of the media community on the safe reporting of suicide-related content.Methods:An interventional single-arm pre and post pilot study was conducted on a sample of the Malaysian media community recruited through purposive and snowball sampling. The media safe reporting workshop was conducted by a suicide prevention expert with a media industry background. Thirty participants completed a self-reported evaluation questionnaire on their awareness and knowledge of reporting on suicide-related media content; before and after the interventional workshop.Results:There was a significant difference between the total scores before and after the intervention, with a large effect size. Post-intervention scores were significantly improved in 8 items, namely those related to the reporting of: (i) the content of any suicide note; (ii) headlines with methods of suicide; (iii) headlines with the location of suicide; (iv) cases of suspected suicide despite the unconfirmed cause of death; (v) suicide news to cater to readers’ interests; (vi) cause of suicide; (vii) details of the location of suicide; and (viii) the negative impact to media community when reporting suicide stories. In particular, there was an improvement in the majority of items for people from the media community with no lived experience of suicidal behavior.Conclusion:The media safe reporting workshop is a potentially effective intervention for improving awareness and knowledge measures relating to safe reporting on suicide among the media community, with a more pronounced effect in those without lived experience of suicidal behavior. Limitations in the sample size, generalizability, short-term evaluation, and lack of a control group warrant future larger, longer-term controlled, and more representative studies.
Editorial: Caminando hacia las indexaciones y la contribución de la empresa privada……
Authors: Lodeiros Seijo César 
Published: December 2021

AquaTechnica, nace como una iniciativa Rectoral y de la Escuela de Acuicultura y Pesquería de la Universidad Técnica de Manabí, para llenar un vacío en Iberoamérica que evalúe, valide y publique investigaciones realizadas en América Latina y el Caribe, pero no limitadas solo a esas regiones, en función del desarrollo de la acuicultura, que se ha convertido en una de las actividades prioritarias en la seguridad alimentaria de cualquier país y el planeta. De esta manera, en el año 2019 nace AquaTechnica, con el aval y acompañamiento de la red AquaCibus: Fortaleciendo la acuicultura en Iberoamérica: calidad, competitividad y sostenibilidad del programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED).

Con el presente número, AquaTechnica ha publicado 5 números con artículos en diferentes áreas y disciplinas de la acuicultura y, sin contar con 2 años (período que normalmente una revista científica puede optar a ser evaluada para indexaciones) ya fue evaluada e indexada en la Red Iberoamericana de Innovación y Conocimiento Científico (REDIB), la cual es una plataforma de agregación de contenidos científicos y académicos en formato electrónico producidos en el ámbito iberoamericano. De igual manera, se puede encontrar en BASE, el cual es uno de los motores de búsqueda más voluminosos del mundo, especialmente para recursos web académicos que proporciona el acceso a más de 240 millones de documentos, originarios de más de 8.000 proveedores de contenido.
Editorial | Iberoamérica: una potencia productiva mundial al desarrollo de nuevo conocimiento para cultivos acuícolas en el marco de la Seguridad y Soberanía Alimentaria
Authors: Sonnenholzner Varas Jorge 
Published: December 2021

Iberoamérica, sufre una de las peores recesiones económicas registradas de los últimos 200 años a causa del brote del Covid-19; y muchos de los sistemas de producción alimentaria ya enfrentan presiones múltiples con un rendimiento productivo erosionado. No obstante, se continúa dando soporte y fuerte impulso a la Agenda 2030 de las Naciones Unidas para lograr alcanzar una acuicultura de cuarta generación con tecnología de sistemas de producción con desarrollo alto.

Ante esta compleja realidad, varios países y regiones de Iberoamérica destacan al conformar un gran paisaje bioalimentario único desde la acuicultura que intervienen en organizar y reformar el sistema alimentario mundial. Los países mejor posicionados con recursos financieros y humanos dedicados a la I+D son los ibéricos Portugal y España, pero también en América Brasil, Uruguay, Argentina, Chile y México y sin duda, se darán más pasos centrados en soluciones basadas en lo imprescindible de la ciencia, la tecnología y la innovación para una acuicultura al 2050 con producción masiva de semillas y juveniles de nuevas especies nativas.

Pese a la reducida cantidad de recursos que se destinan a I+D, Ecuador, por su privilegiada ubicación geográfica (en términos del perfil bioclimático y oceanográfico) y extensa productiva plataforma continental, tiene enorme potencial y proyección que ofrecer para la acuicultura, aparte de su impecable desempeño en la acuicultura del camarón blanco del Pacífico (Penaeus vannamei) con las ya más de 800.000 t en producción de camarón, con las cuales se pretenden cerrar este año 2021. Ecuador cuenta, particularmente a expensas de la industria de la camaronicultura, con el desarrollo de infraestructura de control de parámetros para rentabilidad de la producción, el uso eficiente de los recursos en tiempo real, y mejoras en la bioseguridad e inocuidad. Todo ello, lo convierte en destino relevante dentro del comercio internacional con la posibilidad de iniciativas de nuevos cultivos de recursos nativos, tales como peces, moluscos bivalvos, equinodermos (pepinos de mar y erizos de mar), algas marinas, entre otros grupos.
Some psychophysiological parameters of a person during a passive orthostatic test
Authors: Karpikova T.S. , Semiletova V.A. , Dorokhov E.V. 
Published: December 2021

The study involved 14 volunteer students. Situational anxiety was determined, tests were carried out to determine simple and complex sensorimotor reactions, the cardiac rhythm of the subjects was recorded. Oxygen saturation was determined using an oximeter. Dynamic parameters were recorded: lying in a state of functional rest (background 1), vertical at 65-70° (vertical), lying after verticalization (horizontal), lying in a state of functional rest (background 2). The analysis of the data obtained was carried out using the Excel and StatPlus Pro programs. It was revealed that during verticalization, changes in the regulation of the heart activity of the subjects are carried out mainly due to the central mechanisms of regulation through the sympathetic nervous system. The transfer from a vertical to a horizontal state is accompanied by a restructuring of the regulatory system towards the activation of subcortical nerve centers and a shift in the balance of the SNS/PSNS towards the parasympathetic nervous system.
Key words: passive orthostatic test, cardiac rhythm, simple sensorimotor reaction.
Intermittent normobaric hypoxia as a method of correction and prevention of functional changes in old age
Authors: Klyuchnikova E.A. , Balykin M.V. 
Published: December 2021

The study involved men aged 60-65 years. The course of intermittent normobaric hypoxia (APG) was carried out for 3 weeks with breathing hypoxic gas mixture with 18-15-13-10% O2. Before and after the course, the reactivity of the cardiovascular system and blood system, physical performance were evaluated. It has been established that the course of APG increases oxidative metabolism, leads to a decrease in the level of sugar, total lipids and low-density lipids in the blood, an increase in the number of red blood cells, helps to reduce and stabilize blood pressure, increase physical performance of the elderly. The results of the study indicate the possibility of using APG as a method of correction and prevention of functional changes in the elderly.
Key words: hypoxia, old age, blood, physical performance.
On the effectiveness of integration of a rehabilitation device based on a neurointerface and neurostimulation of the spinal cord in the rehabilitation of patients with impaired upper limb movement due to neurological disorders
Authors: Shandybina N. , Ananyev S. , Aliev А. , Shalmiev I. , Kozureva S. , Averkiev M. , Bulanov V. , Potantsev Yu. , Lavrov I. , Gerasimenko Yu. , Moshonkina T. , Lebedev M. 
Published: December 2021

Millions of people around the world suffer from disorders caused by injuries and diseases of the brain and spinal cord. The combination of brain-computer interfaces and neuromodulation technologies is a new approach that could revolutionize the treatment of these disorders. In this study, we tested the effectiveness of a technique in which a patient with a spinal cord injury first undergoes spinal cord stimulation and then participates in a rehabilitation session using a brain-computer interface based on the P300 principle, which decodes visual-motor transformation and uses an assistive robot that moves the patient’s arm, and virtual reality. All healthy participants of the study were able to combine these two techniques without any undesirable effects; studies on patients with spinal cord injury are ongoing. System integration of the two methods has been already performed, and in the future, upon completion of this work, the neural interface will be able to control the stimulation parameters. We propose such integrated systems as a new approach to neurorehabilitation.
Key words: brain-computer interface, neuromodulation, spinal cord stimulation, spinal cord trauma, P300, visuomotor transformation.
Physical training as a means of increasing the body's resistance to adverse factors
Authors: Baranova O.V. , Romanov K.V. , Dmitrieva N.G. 
Published: December 2021

The features of improving resistance to gravitational overload and motion sickness in aviation specialists by means of physical training are considered, the orientation, structure, content and methodology of physical training are determined. The data obtained allow us to conclude that the developed training methods have a positive effect on many functional indicators of the body of pilots, which contributes to adaptation to flight activities in a short time.
Key words: gravitational overload, motion sickness, physical training, flight activity.
Еffects of percutaneous electrical stimulation of the spinal cord in combination with mechanotherapy on changes in systemic and regional hemodynamics
Authors: Golodnova V.A. , Ananyev S.S. , Bikbaeva Y.Y. , Balykin M.V. , Antipov I.V. 
Published: December 2021

Objective: to evaluate changes in systemic and cerebral hemodynamics during percutaneous electrical stimulation of the spinal cord and in combination of electrical stimulation with mechanotherapy. Methodology. The subjects underwent percutaneous electrical stimulation of the spinal cord, the duration of the session was 5 minutes. Mechanotherapy was performed using a treadmill. The subjects performed walking at a power of 25W. for 5 minutes. Hemodynamics was evaluated before and after the electrical stimulation session, as well as before and after the mechanical therapy session on the track in combination with percutaneous electrical stimulation of the spinal cord. To study systemic and regional hemodynamics, a rheograph-polyanalyzer "REAN-POLY" was used. Results. Electrical stimulation of the spinal cord does not lead to significant changes in systemic and cerebral hemodynamics. Percutaneous electrical stimulation of the spinal cord in combination with physical exertion leads to reactive changes in systemic hemodynamics, increased blood filling and venous outflow, against the background of a decrease in peripheral resistance of cerebral vessels.
Key words: electrostimulation, percutaneous electrostimulation, mechanotherapy, systemic hemodynamics, regional hemodynamics.
Psychophysiological features of the sport's influence on the regulatory and adaptive abilities of teenagers
Authors: Gondareva L.N. , Kurakina O.V. , Stolyarov A.A. , Sokunova S.F. 
Published: December 2021

It is shown, that sport activities and shooting extremelly increase workability, self-control, impact on development of blood circulation's adaptation and optimization.
Key words: teenage, floorball, stand shooting, brain abilities, psychophysiological comfort, cardiovascular system.
Analysis of the combined effect of long-term heat light soaking and KF/NaF post-deposition treatment on the open-circuit voltage loss in CIGS solar cells
Authors: Tangara Hamidou , He Yulu , Islam Muhammad Monirul , Ishizuka Shogo , Sakurai Takeaki 
Published: December 2021

Abstract
Heat light soaking (HLS) has been known to impact the photovoltaic parameters of Cu(In,Ga)Se2 (CIGS) solar cells for a long time. Recently, the focus shifted to the effect of the procedure on alkali fluoride-treated CIGS. Here, we investigate the impact of long-term HLS on the open-circuit (V
OC) loss in high-efficiency CIGS with potassium fluoride (KF) and sodium fluoride (NaF) post-deposition treatment (PDT). HLS is shown to increase the net doping density, however, the subsequent improvement of the V
OC is lower than expected. Using an analysis based on the SQ theory, we show that HLS reduces the nonradiative recombination rate in the bulk but increases the one at the interface. We present a model to explain the increase of interface recombination. We further demonstrate that a combination of HLS and KF/NaF-PDT is necessary to enhance the positive impacts of HLS and mitigate the detrimental ones leading to high-efficiency CIGS devices (22%).