bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study of Ionospheric Day‐To‐Day Variability Over Wuhan Based on Ionosonde Measurements and Model Simulations
Authors: Zhou Xu , Yue Xinan , Liu Han‐Li , Lu Xian , Wu Haonan , Zhao Xiukuan , He Jianhui 
Published: March 2021

AbstractIonospheric day‐to‐day variability is essential for understanding the space environment, while it is still challenging to properly quantify and forecast. In the present work, the day‐to‐day variability of F2 layer peak electron densities (NmF2) is examined from both observational and modeling perspectives. Ionosonde data over Wuhan station (30.5°N, 114.5°E; 19.3°N magnetic latitude) are compared with simulations from the specific dynamics Whole Atmosphere Community Climate Model with thermosphere and ionosphere eXtension (SD‐WACCM‐X) and the Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model (TIEGCM) in 2009 and 2012. Both SD‐WACCM‐X and TIEGCM are driven by the realistic 3 h geomagnetic index and daily solar input, and the former includes self‐consistently solved physics and chemistry in the lower atmosphere. The correlation coefficient between observations and SD‐WACCM‐X simulations is much larger than that of the TIEGCM simulations, especially during dusk in 2009 and nighttime in 2012. Both the observed and SD‐WACCM‐X simulated day‐to‐day variability of NmF2 reveal a similar day‐night dependence in 2012 that increases large during the nighttime and decreases during the daytime, and shows favorable consistency of daytime variability in 2009. Both the observations and SD‐WACCM‐X simulations also display semiannual variations in nighttime NmF2 variability, although the month with maximum variability is slightly different. However, TIEGCM does not reproduce the day‐night dependence or the semiannual variations well. The results emphasize the necessity for realistic lower atmospheric perturbations to characterize ionospheric day‐to‐day variability. This work also provides a validation of the SD‐WACCM‐X in terms of ionospheric day‐to‐day variability.
Stress Drop Variations in the Region of the 2014 MW8.1 Iquique Earthquake, Northern Chile
Authors: Folesky Jonas , Kummerow Jörn , Shapiro Serge A. 
Published: March 2021

AbstractWe compute stress drops from P and S phase spectra for 534 earthquakes in the source region of the 2014 MW8.1 Iquique megathrust earthquake in the northern Chilean subduction zone. An empirical Green's function based method is applied to suitable event pairs selected by template matching of eight years of continuous waveform data. We evaluate the parameters involved in the stress drop estimation, consider the effect of the local velocity structure and apply an empirical linear relation between P and S phase related geometry factors (k values). Data redundancy produced by multiple empirical Green's function and the combination of P and S phase spectra leads to a substantial reduction of uncertainty and robust stress drop estimates. The resulting stress drop values show a well‐defined log‐normal distribution with a median value of 4.36 MPa; most values range between 0.1 and 100 MPa. There is no evidence for systematic large scale lateral variations of stress drop. A detailed analysis reveals several regions of increased median stress drop, an increase with distance to the interface, but no consistent increase with depth. This suggests that fault regime and fault strength have a stronger impact on the stress drop behavior than absolute stresses. Interestingly, we find a weak time‐dependence of the median stress drop, with an increase immediately before the April 1, 2014 MW8.1 Iquique mainshock, a continuous reduction thereafter and a subsequent recovery to average values. Additionally, the data set indicates a relatively strong dependence of stress drop on magnitude which extends over the entire analyzed magnitude range.
Methane Hydrate Formation and Evolution During Sedimentation
Authors: You K. , Flemings P. B. 
Published: March 2021

AbstractWe explored methane hydrate formation with sedimentation with a newly developed one‐dimensional, multiphase flow, multicomponent transport numerical model. Our model couples methane hydrate formation from in situ microbial methane generation within the hydrate stability zone (HSZ), methane recycling, and microbial methane generation below the base of the hydrate stability zone (BHSZ). Both recycled methane and deeply generated methane are transported into the HSZ by buoyancy‐driven free gas flow. Free gas flows through the HSZ by both the processes of capillary‐dependent pore fillings and by salt exclusion during hydrate formation, with the former being the dominant mechanism. We quantitively illustrated the formation of enriched hydrate in muddy sediments above, and interconnected free gas below, the BHSZ, which are common features along the world's continental margin. In addition, we showed two ways to form concentrated methane hydrate above the BHSZ. The first mechanism is local free gas flow during methane recycling. This happens at sites with sufficient methane generation above the BHSZ. The second mechanism is deep microbial methane generation which is transported into the HSZ by free gas flow. This mechanism plays a more important role at sites with high sedimentation rates. This study provides new insights into methane hydrate formation and distribution below the seafloor. It is important for understanding the carbon cycle and carbon storage below the seafloor and for resource evaluation and exploitation.
Bed‐Load Transport in Vegetated Flows: Phenomena, Parametrization, and Prediction
Authors: Wu Haoliang , Cheng Nian‐Sheng , Chiew Yee‐Meng 
Published: March 2021

AbstractThis study presents an experimental study on bed‐load transport in the presence of emergent vegetation, which is simulated using uniformly sized circular cylinders arranged in a homogeneous distribution. The spatial variability of bed‐load fluxes in vegetated flows is first examined. Then a model is proposed for evaluating the bed‐load transport rate based on the scour holes that form around the vegetation stems. The influences of spatial variability and intensified turbulence on sediment transport are finally considered by relating the dimensionless transport rate and flow intensity to the stem size and vegetation density. The derived formula for predicting the bed‐load transport rate in vegetated flows is applicable for weak to moderate transport conditions.
Integrating Gravimetry Data With Thermal Infra‐Red Data From Satellites to Improve Efficiency of Operational Irrigation Advisory in South Asia
Authors: Bose Indira , Hossain Faisal , Eldardiry Hisham , Ahmad Shahryar , Biswas Nishan K. , Bhatti Ahmad Zeeshan , Lee Hyongki , Aziz Mazharul , Kamal Khan Md. Shah 
Published: March 2021

AbstractThe rapid decline of groundwater resources in South Asia due to excessive irrigation during dry season requires awareness of optimal on‐field water requirements. Such information is currently provided on farmer cellphones through an operational Irrigation Advisory System (IAS). To minimize the cost of sending such irrigation advisory texts to farmers while maximizing impact of IAS on groundwater sustainability, we integrated Gravity Recovery and Climate Experiment (GRACE) data with Landsat Thermal Infrared (TIR) Imagery to target regions in greater need of the IAS service. We demonstrated the concept of an improved IAS over eight irrigation districts of the Ganges and Indus basins. The Surface Energy Balance Algorithm for Land (SEBAL) was used to monitor on‐field water consumption (evapotranspiration‐ET) over cropped areas using Landsat TIR data at plot‐scale spatial resolution. Comparison of SEBAL ET with crop water demand from Penman‐Monteith (FAO56) technique quantified the extent of overirrigation at the plot scale and provided a tangible pathway to microtarget the IAS service only to farmers with the largest groundwater use footprint, thereby improving the impact of the IAS service further. Our results suggested that an operational IAS that integrates GRACE and Landsat TIR data on average can save about 85% (80 million m3) of groundwater per dry season for irrigation districts of Northern India and 87% (or 150 million m3) per year for irrigation districts of Eastern Pakistan.
Predicting the Effect of Relaxation on Interfacial Area Development in Multiphase Flow
Authors: Meisenheimer Douglas E. , Wildenschild Dorthe 
Published: March 2021

AbstractA variety of two‐phase flow experiments, currently available in the literature, are compared to study the effect of fluid relaxation on interfacial area generation. Interfacial area is an important parameter that controls mass transfer in many engineered multiphase systems, so it is important to develop accurate predictive tools describing multiphase flow to engineer efficient processes. An empirical predictive relationship was developed describing a specific interfacial area‐wetting saturation relationship that depends on the number of quasi‐equilibrium relaxation points obtained during a drainage or imbibition experiment. The empirical expression was tested and verified using a number of existing datasets. We found that different relationships were needed depending on the fluid properties as well as the porous medium. However, clear trends were observed that can, once a predictive relationship is established for the system, allow us to design multiphase flow systems to produce a desired amount of interfacial area tailored to a particular application.
Glass crystallization making red phosphor for high-power warm white lighting
Authors: Hu Tao , Ning Lixin , Gao Yan , Qiao Jianwei , Song Enhai , Chen Zitao , Zhou Yayun , Wang Jing , Molokeev Maxim S. , Ke Xiaoxing , Xia Zhiguo , Zhang Qinyuan 
Published: March 2021

AbstractRapid development of solid-state lighting technology requires new materials with highly efficient and stable luminescence, and especially relies on blue light pumped red phosphors for improved light quality. Herein, we discovered an unprecedented red-emitting Mg2Al4Si5O18:Eu2+ composite phosphor (λex = 450 nm, λem = 620 nm) via the crystallization of MgO–Al2O3–SiO2 aluminosilicate glass. Combined experimental measurement and first-principles calculations verify that Eu2+ dopants insert at the vacant channel of Mg2Al4Si5O18 crystal with six-fold coordination responsible for the peculiar red emission. Importantly, the resulting phosphor exhibits high internal/external quantum efficiency of 94.5/70.6%, and stable emission against thermal quenching, which reaches industry production. The maximum luminous flux and luminous efficiency of the constructed laser driven red emitting device reaches as high as 274 lm and 54 lm W−1, respectively. The combinations of extraordinary optical properties coupled with economically favorable and innovative preparation method indicate, that the Mg2Al4Si5O18:Eu2+ composite phosphor will provide a significant step towards the development of high-power solid-state lighting.
Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer
Authors: Shen Tong , Liu Jing-Lin , Wang Chu-Yi , Rixiati Youlutuziayi , Li Shi , Cai Ling-Dong , Zhao Yuan-Yuan , Li Jian-Ming 
Published: March 2021

AbstractThe mechanisms and key factors involved in tumor environments for lung metastasis of CRC are still unclear. Here, using clinical samples from lung metastases of CRC patients, we found that intestinal immune network for IgA production was significantly dysregulated in lung metastases of CRC. Single-cell RNA sequencing discovered a subtype of B cells positive for Erbin, one member of the leucine-rich repeat and PDZ domain (LAP) family, was involved in the lung metastases. Erbin deletion in B cells suppressed lung metastasis of CRC in vivo. And, deletion of Erbin in B cells enhanced the killing effects of CD8+ T cells on tumor cells. Mechanistically, Erbin knockout attenuated TGFβ-mediated suppression of migration of CXCR5+ IgA+ cells and STAT6-mediated PD1 expression. Our study uncovered a key role of Erbin in regulating PD1+ IgA+ B cells in lung metastasis of CRC. Targeting Erbin as well as combined use of neutralizing B cells and antibodies neutralizing PD1 suppresses lung metastasis of CRC in mice, suggesting the potential option for treatment of lung metastasis of CRC.
Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease
Authors: Budhram-Mahadeo Vishwanie S. , Solomons Matthew R. , Mahadeo-Heads Eeshan A. O. 
Published: March 2021

AbstractMetabolic and cardiovascular diseases are highly prevalent and chronic conditions that are closely linked by complex molecular and pathological changes. Such adverse effects often arise from changes in the expression of genes that control essential cellular functions, but the factors that drive such effects are not fully understood. Since tissue-specific transcription factors control the expression of multiple genes, which affect cell fate under different conditions, then identifying such regulators can provide valuable insight into the molecular basis of such diseases. This review explores emerging evidence that supports novel and important roles for the POU4F2/Brn-3b transcription factor (TF) in controlling cellular genes that regulate cardiometabolic function. Brn-3b is expressed in insulin-responsive metabolic tissues (e.g. skeletal muscle and adipose tissue) and is important for normal function because constitutive Brn-3b-knockout (KO) mice develop profound metabolic dysfunction (hyperglycaemia; insulin resistance). Brn-3b is highly expressed in the developing hearts, with lower levels in adult hearts. However, Brn-3b is re-expressed in adult cardiomyocytes following haemodynamic stress or injury and is necessary for adaptive cardiac responses, particularly in male hearts, because male Brn-3b KO mice develop adverse remodelling and reduced cardiac function. As a TF, Brn-3b regulates the expression of multiple target genes, including GLUT4, GSK3β, sonic hedgehog (SHH), cyclin D1 and CDK4, which have known functions in controlling metabolic processes but also participate in cardiac responses to stress or injury. Therefore, loss of Brn-3b and the resultant alterations in the expression of such genes could potentially provide the link between metabolic dysfunctions with adverse cardiovascular responses, which is seen in Brn-3b KO mutants. Since the loss of Brn-3b is associated with obesity, type II diabetes (T2DM) and altered cardiac responses to stress, this regulator may provide a new and important link for understanding how pathological changes arise in such endemic diseases.
Combinatorial mechanical gradation and growth factor biopatterning strategy for spatially controlled bone-tendon-like cell differentiation and tissue formation
Authors: Wang Dan , Ker Dai Fei Elmer , Ng Ka Wai , Li Ke , Gharaibeh Burhan , Safran Marc , Cheung Emilie , Campbell Phil , Weiss Lee , Yang Yunzhi Peter 
Published: March 2021

AbstractEngineering scaffolds to augment the repair of hard-to-soft multitissue musculoskeletal tissue units, such as bone-tendon, to simultaneously support tissue healing and functional movement has had limited success. Overcoming this challenge will require not only precise spatial control of bone- and tendon-like biomechanical properties, but also consideration of the resultant biomechanical cues, as well as the embedded biochemical cues imparted by these scaffolds. Here, we report on the effects of a spatially engineered combination of stiffness and growth factor (GF) cues to control bone-tendon-like differentiation in vitro and tissue formation in vivo. This was achieved using mechanically graded, bone- and tendon-like QHM polyurethane (QHM: Q: Quadrol; H: hexamethylene diisocyanate; M: methacrylic anhydride) scaffolds selectively biopatterned with osteogenic bone morphogenetic protein-2 (BMP-2) and tenogenic fibroblast growth factor-2 (FGF-2). First, material characterization, including porosity, surface roughness, contact angle, and microindentation measurements, was performed. Second, in vitro studies demonstrated that increased material stiffness promoted GF-mediated osteoblast differentiation and reduced tenocyte differentiation. Sustained GF exposure masked this stiffness effect. Third, in vivo studies involving subcutaneous implantation of mechanically graded and biochemically patterned QHM scaffolds (composed of these bone- and tendon-promoting GFs biopatterned on biphasic bone and tendon biomechanically mimicking regions) in mice demonstrated spatial control of bone- and tendon-like tissue formation. Altogether, these data provide new insights for future engineering of scaffolds to augment hard-to-soft multitissue repair.
Light-activated shape morphing and light-tracking materials using biopolymer-based programmable photonic nanostructures
Authors: Wang Yu , Li Meng , Chang Jan-Kai , Aurelio Daniele , Li Wenyi , Kim Beom Joon , Kim Jae Hwan , Liscidini Marco , Rogers John A. , Omenetto Fiorenzo G. 
Published: March 2021

AbstractNatural systems display sophisticated control of light-matter interactions at multiple length scales for light harvesting, manipulation, and management, through elaborate photonic architectures and responsive material formats. Here, we combine programmable photonic function with elastomeric material composites to generate optomechanical actuators that display controllable and tunable actuation as well as complex deformation in response to simple light illumination. The ability to topographically control photonic bandgaps allows programmable actuation of the elastomeric substrate in response to illumination. Complex three-dimensional configurations, programmable motion patterns, and phototropic movement where the material moves in response to the motion of a light source are presented. A “photonic sunflower” demonstrator device consisting of a light-tracking solar cell is also illustrated to demonstrate the utility of the material composite. The strategy presented here provides new opportunities for the future development of intelligent optomechanical systems that move with light on demand.
Digital proximity tracing on empirical contact networks for pandemic control
Authors: Cencetti G. , Santin G. , Longa A. , Pigani E. , Barrat A. , Cattuto C. , Lehmann S. , Salathé M. , Lepri B. 
Published: March 2021

AbstractDigital contact tracing is a relevant tool to control infectious disease outbreaks, including the COVID-19 epidemic. Early work evaluating digital contact tracing omitted important features and heterogeneities of real-world contact patterns influencing contagion dynamics. We fill this gap with a modeling framework informed by empirical high-resolution contact data to analyze the impact of digital contact tracing in the COVID-19 pandemic. We investigate how well contact tracing apps, coupled with the quarantine of identified contacts, can mitigate the spread in real environments. We find that restrictive policies are more effective in containing the epidemic but come at the cost of unnecessary large-scale quarantines. Policy evaluation through their efficiency and cost results in optimized solutions which only consider contacts longer than 15–20 minutes and closer than 2–3 meters to be at risk. Our results show that isolation and tracing can help control re-emerging outbreaks when some conditions are met: (i) a reduction of the reproductive number through masks and physical distance; (ii) a low-delay isolation of infected individuals; (iii) a high compliance. Finally, we observe the inefficacy of a less privacy-preserving tracing involving second order contacts. Our results may inform digital contact tracing efforts currently being implemented across several countries worldwide.
Circadian control of hepatitis B virus replication
Authors: Zhuang Xiaodong , Forde Donall , Tsukuda Senko , D’Arienzo Valentina , Mailly Laurent , Harris James M. , Wing Peter A. C. , Borrmann Helene , Schilling Mirjam , Magri Andrea , Rubio Claudia Orbegozo , Maidstone Robert J. , Iqbal Mudassar , Garzon Miguel , Minisini Rosalba , Pirisi Mario , Butterworth Sam , Balfe Peter , Ray David W. , Watashi Koichi , Baumert Thomas F. , McKeating Jane A. 
Published: March 2021

AbstractChronic hepatitis B virus (HBV) infection is a major cause of liver disease and cancer worldwide for which there are no curative therapies. The major challenge in curing infection is eradicating or silencing the covalent closed circular DNA (cccDNA) form of the viral genome. The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the liver transcriptome and yet their role in HBV replication is unknown. We establish a circadian cycling liver cell-model and demonstrate that REV-ERB directly regulates NTCP-dependent hepatitis B and delta virus particle entry. Importantly, we show that pharmacological activation of REV-ERB inhibits HBV infection in vitro and in human liver chimeric mice. We uncover a role for BMAL1 to bind HBV genomes and increase viral promoter activity. Pharmacological inhibition of BMAL1 through REV-ERB ligands reduces pre-genomic RNA and de novo particle secretion. The presence of conserved E-box motifs among members of the Hepadnaviridae family highlight an evolutionarily conserved role for BMAL1 in regulating this family of small DNA viruses.
Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans
Authors: Izotova Natalia , Rivat Christine , Baricordi Cristina , Blanco Elena , Pellin Danilo , Watt Eleanor , Gkazi Athina S. , Adams Stuart , Gilmour Kimberly , Bayford Jinhua , Booth Claire , Gaspar H. Bobby , Thrasher Adrian J. , Biasco Luca 
Published: March 2021

AbstractOur mathematical model of integration site data in clinical gene therapy supported the existence of long-term lymphoid progenitors capable of surviving independently from hematopoietic stem cells. To date, no experimental setting has been available to validate this prediction. We here report evidence of a population of lymphoid progenitors capable of independently maintaining T and NK cell production for 15 years in humans. The gene therapy patients of this study lack vector-positive myeloid/B cells indicating absence of engineered stem cells but retain gene marking in both T and NK. Decades after treatment, we can still detect and analyse transduced naïve T cells whose production is likely maintained by a population of long-term lymphoid progenitors. By tracking insertional clonal markers overtime, we suggest that these progenitors can support both T and NK cell production. Identification of these long-term lymphoid progenitors could be utilised for the development of next generation gene- and cancer-immunotherapies.