bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apendicitis aguda complicada en pacientes pediátricos con antecedentes de “empacho” y manipulación abdominal: serie de casos
Authors: Aguilar-Andino David , Licona Rivera Tania Soledad , Osejo Quan Jorge Alberto , Carranza Linares Ricardo Jafet , Molina Soto Marco Antonio , Alas-Pineda César 
Published: April 2021

Según la cultura popular latinoamericana, el empacho es una enfermedad intestinal causada por ingesta excesiva de alimentos, fríos o mal cocidos. La manipulación abdominal o “sobada” es uno de los tratamientos populares utilizados para el empacho y consiste en un masaje abdominal, donde se frota, se estira la piel y se aplica presión sobre el abdomen.Objetivos: Caracterizar la evolución clínica y las complicaciones secundarias al retraso diagnóstico, en pacientes pediátricos con apendicitis aguda, con antecedente de empacho y manipulación abdominal.Pacientes y Método: Estudio observacional descriptivo, prospectivo de pacientes pediátricos con apendicitis aguda complicada con antecedente de manipulación abdominal, captados en la sala de cirugía pediátrica entre noviembre del 2019 y junio del 2020 en el Hospital Mario Catarino Rivas. Se empleó estadística descriptiva para el análisis.Resultados: Se estudiaron 10 pacientes, rango de edad 6 a 16 años (mediana 14 años), 50% procedente de zonas rurales. Los principales síntomas que se presentaron previo a la manipulación abdominal fueron: vómitos, náuseas y anorexia, posterior a lo cual se agregó diarrea espontanea o estreñimiento y aumento de la intensidad del dolor. Las complicaciones fueron perforación intestinal (5/10), plastrón apendicular (3/10), absceso intraabdominal (3/10), y apéndice en fase gangrenosa (1/10). La mediana de tiempo entre síntoma inicial y hospitalización fue 60 horas [IQR, 33,0-72,0].Conclusión: Se describe la influencia del empacho y su respectivo tratamiento en el deterioro clínico debido al retraso diagnóstico y del tratamiento de la apendicitis aguda, dando como resultado distintas complicaciones.
Nikah Khitbah:Alternatif Penyelesaian Anak Tak Sah Taraf
Authors: Abdullah Muhamad Mu'izz 
Published: April 2021

Perkahwinan berlandaskan syariat islam merupakan suatu perkara yang amat penting kerana boleh memberi kesan pada perjalanan hidup penganutnya dalam membentuk masyarakat muslim yang harmoni. Akan tetapi, kita menyaksikan bahawa kadar peningkatan anak tak sah taraf dalam kalangan remaja saban tahun begitu membimbangkan akibat daripada hubungan tidak sah di sisi syarak. Ini memberi kesan yang negatif terhadap institusi kekeluargaan dan juga kepada masyarakat secara amnya. Oleh itu, kajian ini bertujuan untuk mengkaji sejauh mana keberkesanan pelaksanaan nikah khitbah dalam kalangan remaja sebagai satu alternatif mengurangkan kadar zina dan anak tak sah taraf. Solusi yang dicadangkan ini adalah sebagai alternatif kepada tindakan pencegahan sedia ada. Penulis menggunakan metod kajian berbentuk analisis dokumen dengan melihat kepada kitab-kitab fiqh, keratan akhbar, fatwa-fatwa negeri. Hasil kajian mendapati bahawa nikah khitbah adalah relevan untuk dilaksanakan bagi mengatasi masalah ini. Walau bagaimanapun, pelaksanaannya perlu diberikan garis panduan dan pendedahan sewajarnya oleh pihak berwajib. Diharapkan kajian ini dapat memberi pendedahan dalam kalangan masyarakat akan kepentingan nikah khitbah seterusnya mengurangkan peningkatan kes anak tak sah taraf.
Konsep Halalan Tayiban (HT) dan Aplikasinya Dalam Program Pelatihan di Institut Penyelidikan Produk Halal (IPPH), Universiti Putra Malaysia (UPM)
Authors: Gunardi Setiyawan 
Published: April 2021

Konsep Halalan Tayiban (HT) amat diperlukan bagi kehidupan manusia di muka bumi ini. Oleh itu, konsep HT ini perlu diaplikasikan ke mana-mana bidang bagi menjaga kehidupan dalam keadaan selamat dan sihat secara menyeluruh. Industri halal pada masa kini amat memerlukan konsep HT sama ada melalui pendekatan penyelidikan dan pengajaran yang dapat menjamin kehalalan produk yang dikeluarkan. Pelbagai strategi telahpun dicadang dan dirancang melalui program pelatihan yang berasaskan kepada pembelajaran dan pengajaran bagi memberi pendedahan dalam konsep ini. Oleh itu, perlu kepada program pelatihan yang boleh membawa kefahaman Halalan Tayiban dengan benar. Institut Penyelidikan Produk Halal (IPPH) Universiti Putra Malaysia (UPM) adalah sebuah institusi yang bergerak dalam bidang penyelidikan dan mempunyai perkhidmatan yang progresif dan innovatif dalam membangunkan konsep HT. Objektif kajian ini menjelaskan konsep HT menurut Syariah. Juga mendedahkan sejarah penubuhan IPPH dan perkhidmatan serta program pelatihan yang ditawarkan serta peranan institut dalam industri halal. Untuk mendapati hasil kajian yang diinginkan, maka kajian ini menggunakan metod kualitatif deskriptif melalui kajian kepustakaan dan kajian lapangan. Kajian kepustakaan bersumber kepada al-Quran dan a.-Sunnah, serta artikel penulisan ilmiah yang berkaitan, manakala kajian lapangan pula dengan menemubual pihak IPPH dan website institut. Setelah semua data didapat, maka kajian ini mendapati bahawa IPPH UPM mempunyai peranan penting dalam usaha membangunkan industri HT di Malaysia melalui program pelatihan. Implikasi kajian ini memberi kesedaran orang ramai dan pemain indutri halal yang berminat menceburi bidang HT untuk menyertai program IPPH UPM dan memahami konsep dengan benar mengikut kepiawaian syariah.
Dampak Pandemi Covid-19 terhadap Pengelolaan Keuangan Negara
Authors: Suparman Nanang 
Published: April 2021

Kajian ini akan mengungkapkan tentang kebijakan pengelolaan keuangan negara untuk penanganan pandemi Covid-19 di Indonesia. Dampak pandemi ini telah menyebabkan kelumpuhan sektor usaha kecil menengah yang dipicu menurunnya daya beli masyarakat, sedangkan pada sektor industri manufaktur mengalami penurunan supply dan demand yang tajam, terganggunya rantai pasok dan pemutusan hubungan kerja, sehingga terjadi penurunan penerimaan negara dari sektor pajak. Pertumbuhan ekonomi nasional yang minus 5,32 persen pada kuartal kedua dikhawatirkan dapat memicu resesi dan krisis sehingga respon extraordinary pengelolaan keuangan negara ditempuh untuk mengantisipasi kondisi berat dan sangat berat yang mungkin bisa terjadi. Metode penelitian dengan pendekatan kualitatif menggunakan data sekunder yang dapat memberikan analisis pengelolaan keuangan negara terhadap stimulus ekonomi. Pengalokasian anggaran ditujukan untuk infrastuktur kesehatan dan berbagai paket stimulus pemberdayaan masyarakat, penguatan sektor dunia usaha, dan penyiapan keberlanjutan kegiatan ekonomi melalui program pemulihan ekonomi nasional searah dengan upaya penemuan vaksin Covid-19.
Pengaruh Penyaluran Dana Desa pada Indikator Perekonomian Kabupaten Daerah Tertinggal di Indonesia
Authors: Otheliansyah Gema , Yasni Raynal 
Published: April 2021

ABSTRACT
The different characteristics in each region in Indonesia make the pattern of economic activity, infrastructure development and human resources in each region are not similar. Thus have implications to inequality problem. There are regions have growth but also there are regions that have growth slowly or can be called underdeveloped areas. To overcome this problem, the central government directs development activities with the main focus on villages and underdeveloped areas. Underdeveloped areas are considered to be lagging behind in various economic and development aspects. The Village Law has mandated the central government to distribute the Village Fund. This study aims to determine the effect of Village Fund distribution on two economic indicators in 122 underdeveloped areas. The analytical method that used in this research is a simultaneous equation model consist of two structural equations. The results showed that the distribution of village funds had a good effect on two economic indicators of underdeveloped areas. Hopefully, the government in underdeveloped areas can use the village fund well to improve the economy in their area.

ABSTRAK
Perbedaaan karakteristik di setiap wilayah di Indonesia mengakibatkan pola pembangunan ekonomi infrastruktur dan sumber daya manusia di tiap daerah menjadi tidak seragam. Hal tersebut berimplikasi pada munculnya masalah ketimpangan. Ada daerah yang maju lebih cepat dan ada juga daerah yang tumbuh lebih lambat atau bisa dikatakan sebagai daerah tertinggal. Untuk mengatasi permasalahan tersebut, pemerintah pusat mengarahkan kegiatan pembangunan di daerah dengan fokus utama desa dan daerah tertinggal. Daerah tertinggal dianggap masih tertinggal di berbagai aspek ekonomi dan pembangunan. Undang-Undang Desa memberikan mandate kepada pemerintah untuk menyalurkan Dana Desa. Penelitian ini bertujuan untuk mengetahui pengaruh penyaluran Dana Desa terhadap dua indikator perekonomian pada 122 kabupaten daerah tertinggal. Metode analisis yang digunakan adalah model persamaan simultan yang terdiri dari dua persamaan struktural. Hasil penelitian menunjukkan bahwa penyaluran dana desa memberikan pengaruh yang baik bagi dua indikator perekonomian daerah tertinggal. Dengan demikian pemerintah di kabupaten daerah tertingga dapat mengoptimalkan penggunaan Dana Desa yang telah disalurkan guna peningkatan perekonomian.
Los murales de “Arte para todos” en Sevilla. Dialéctica entre la conservación y el olvido
Authors: Aleixandre Hernandis Pau 
Published: April 2021

El debate en torno a la conservación preventiva del arte urbano siempre a suscitado escepticismos, debidos en su mayoría por la naturaleza efímera intrínseca en estas manifestaciones artísticas. Sin embargo, en los últimos diez años la proliferación de obras comisionadas ha dado lugar a un nuevo tipo de obra urbana, el mural contemporáneo, sobre las que hay demandas de permanencia, bien sea por las administraciones, bien sea por la comunidad. Este es el caso de los murales de los barrios A y B de San Pablo, en Sevilla, cuya creación estaba ligada a una intención conservadora que, sin embargo, todavía no ha dado lugar a planteamiento de un plan de conservación preventiva llevado a cabo por profesionales y expertos. Nuestra participación en este debate quiere poner un foco de luz a estos murales que una vez gozaron de gran valor para los vecinos de este barrio y cuyo abandono los está dejando cada vez más en el fondo de sus memorias.
Targeting Antisense lncRNA PRKAG2-AS1, as a Therapeutic Target, Suppresses Malignant Behaviors of Hepatocellular Carcinoma Cells
Authors: Ou Yanjiao , Deng Yong , Wang Hong , Zhang Qingyi , Luo Huan , Hu Peng 
Published: April 2021

Objective: Increasing evidence highlights antisense long non-coding RNAs (lncRNAs) as promising therapeutic targets for cancers. Herein, this study focused on the clinical implications and functions of a novel antisense lncRNA PRKAG2-AS1 in hepatocellular carcinoma (HCC).Methods: PRKAG2-AS1 expression was examined in a cohort of 138 HCC patients by RT-qPCR. Overall survival (OS) and disease-free survival (DFS) analyses were presented based on PRKAG2-AS1 expression, followed by ROCs. After silencing PRKAG2-AS1, cell proliferation was assessed via CCK-8, colony formation and EdU staining assays. Migrated and invasive capacities were assessed by wound healing and transwell assays. The relationships between PRKAG2-AS1, miR-502-3p and BICD2 were validated by luciferase reporter, RIP and RNA pull-down assays. The expression and prognostic value of BICD2 were analyzed in TCGA database.Results: PRKAG2-AS1 was up-regulated in HCC than normal tissue specimens. High PRKAG2-AS1 expression was indicative of poorer OS and DFS time. Area under the curves (AUCs) for OS and DFS were 0.8653 and 0.7891, suggesting the well predictive efficacy of PRKAG2-AS1 expression. Targeting PRKAG2-AS1 distinctly inhibited proliferation, migration, and invasion in HCC cells. PRKAG2-AS1 was mainly expressed in cytoplasm of HCC cells. PRKAG2-AS1 may directly bind to the sites of miR-502-3p. Up-regulation of BICD2 was found in HCC tissues and associated with unfavorable prognosis. BICD2 was confirmed to be a downstream target of miR-502-3p. PRKAG2-AS1 could regulate miR-502-3p/BICD2 axis.Conclusion: Our findings identified a novel lncRNA PRKAG2-AS1 that was associated with clinical implications and malignant behaviors. Thus, PRKAG2-AS1 could become a promising therapeutic target.
High-Flow Nasal Cannula for COVID-19 Patients: A Multicenter Retrospective Study in China
Authors: Duan Jun , Zeng Jia , Deng Puyu , Ni Zhong , Lu Rongli , Xia Wenxi , Jing Guoqiang , Su Xiaoping , Ehrmann Stephan , Zhang Wei , Li Jie 
Published: April 2021

Background: High-flow nasal cannula (HFNC) may help avoid intubation of hypoxemic patients suffering from COVID-19; however, it may also contribute to delaying intubation, which may increase mortality. Here, we aimed to identify the predictors of HFNC failure among patients with COVID-19.Methods: We performed a multicenter retrospective study in China from January 15 to March 31, 2020. Two centers in Wuhan (resource-limited centers) enrolled 32 patients, and four centers outside Wuhan enrolled 34 cases. HFNC failure was defined as the requirement of escalation therapy (NIV or intubation). The ROX index (the ratio of SpO2/FiO2 to the respiratory rate) was calculated.Results: Among the 66 patients, 29 (44%) cases experienced HFNC failure. The ROX index was much lower in failing patients than in successful ones after 1, 2, 4, 8, 12, and 24 h of HFNC. The ROX index was independently associated with HFNC failure (OR = 0.65; 95% CI: 0.45–0.94) among the variables collected before and 1 h after HFNC. To predict HFNC failure tested by ROX index, the AUC was between 0.73 and 0.79 for the time points of measurement 1–24 h after HFNC initiation. The HFNC failure rate was not different between patients in and outside Wuhan (41% vs. 47%, p = 0.63). However, the time from HFNC initiation to intubation was longer in Wuhan than that outside Wuhan (median 63 vs. 22 h, p = 0.02). Four patients in Wuhan underwent intubation due to cardiac arrest; in contrast, none of the patients outside Wuhan received intubation (13 vs. 0%, p = 0.05). The mortality was higher in Wuhan than that out of Wuhan, but the difference did not reach statistical significance (31 vs. 12%, p = 0.07).Conclusion: The ROX index can be used to predict HFNC failure among COVID-19 patients to avoid delayed intubation, which may occur in the resource-limited area.
Phenotyping Neuropsychiatric Symptoms Profiles of Alzheimer’s Disease Using Cluster Analysis on EEG Power
Authors: Liu Friedrich , Fuh Jong-Ling , Peng Chung-Kang , Yang Albert C. 
Published: April 2021

Background: There has been an increasing interest in studying electroencephalogram (EEG) as a biomarker of Alzheimer’s disease but the association between EEG signals and patients’ neuropsychiatric symptoms remains unclear. We studied EEG signals of patients with Alzheimer’s disease to explore the associations between patients’ neuropsychiatric symptoms and clusters of patients based on their EEG powers.Methods: A total of 69 patients with mild Alzheimer’s disease (the Clinical Dementia Rating = 1) were enrolled and their EEG signals from 19 channels/electrodes were recorded in three sessions for each patient. The EEG power was calculated by Fourier transform for the four frequency bands (beta: 13–40 Hz, alpha: 8–13 Hz, theta: 4–8 Hz, and delta: &lt;4 Hz). We performed K-means cluster analysis to classify the 69 patients into two distinct groups by the log-transformed EEG powers (4 frequency bands × 19 channels) for the three EEG sessions. In each session, both clusters were compared with each other to assess the differences in their behavioral/psychological symptoms in terms of the Neuropsychiatric Inventory (NPI) score.Results: While EEG band powers were highly consistent across all three sessions before clustering, EEG band powers were different between the two clusters in each session, especially for the delta waves. The delta band powers differed significantly between the two clusters in most channels across the three sessions. Patients’ demographics and cognitive function were not different between both clusters. However, their behavioral/psychological symptoms were different between the two clusters classified based on EEG powers. A higher NPI score was associated with the clustering of higher EEG powers.Conclusion: The present study suggests that EEG power correlates to behavioral and psychological symptoms among patients with mild Alzheimer’s disease. The clustering approach of EEG signals may provide a novel and cost-effective method to differentiate the severity of neuropsychiatric symptoms and/or predict the prognosis for Alzheimer’s patients.
Predicting Dementia With Prefrontal Electroencephalography and Event-Related Potential
Authors: Doan Dieu Ni Thi , Ku Boncho , Choi Jungmi , Oh Miae , Kim Kahye , Cha Wonseok , Kim Jaeuk U. 
Published: April 2021

Objective: To examine whether prefrontal electroencephalography (EEG) can be used for screening dementia.Methods: We estimated the global cognitive decline using the results of Mini-Mental Status Examination (MMSE), measurements of brain activity from resting-state EEG, responses elicited by auditory stimulation [sensory event-related potential (ERP)], and selective attention tasks (selective-attention ERP) from 122 elderly participants (dementia, 35; control, 87). We investigated that the association between MMSE and each EEG/ERP variable by using Pearson’s correlation coefficient and performing univariate linear regression analysis. Kernel density estimation was used to examine the distribution of each EEG/ERP variable in the dementia and non-dementia groups. Both Univariate and multiple logistic regression analyses with the estimated odds ratios were conducted to assess the associations between the EEG/ERP variables and dementia prevalence. To develop the predictive models, five-fold cross-validation was applied to multiple classification algorithms.Results: Most prefrontal EEG/ERP variables, previously known to be associated with cognitive decline, show correlations with the MMSE score (strongest correlation has |r| = 0.68). Although variables such as the frontal asymmetry of the resting-state EEG are not well correlated with the MMSE score, they indicate risk factors for dementia. The selective-attention ERP and resting-state EEG variables outperform the MMSE scores in dementia prediction (areas under the receiver operating characteristic curve of 0.891, 0.824, and 0.803, respectively). In addition, combining EEG/ERP variables and MMSE scores improves the model predictive performance, whereas adding demographic risk factors do not improve the prediction accuracy.Conclusion: Prefrontal EEG markers outperform MMSE scores in predicting dementia, and additional prediction accuracy is expected when combining them with MMSE scores.Significance: Prefrontal EEG is effective for screening dementia when used independently or in combination with MMSE.
Bipolar Disorder and Parkinson's Disease: A 123I-Ioflupane Dopamine Transporter SPECT Study
Authors: Erro Roberto , Landolfi Annamaria , D'Agostino Giulia , Pace Leonardo , Picillo Marina , Scarano Massimo , Cuocolo Alberto , Pappatá Sabina , Vitale Carmine , Pellecchia Maria Teresa , Monteleone Palmiero , Barone Paolo 
Published: April 2021

Objectives: Bipolar disorder (BD) has been suggested to be a risk factor for the development of Parkinson's disease (PD). Standard treatment of BD includes drugs that are known to induce drug-induced parkinsonism (DIP). Clinical differentiation between PD and DIP is crucial and might be aided by functional neuroimaging of the dopaminergic nigrostriatal pathway.Methods: Twenty consecutive BD patients with parkinsonism were clinically assessed and underwent 123I-ioflupane dopamine transporter single-photon emission computer tomography (SPECT). Imaging data of BD patients with pathological scans were further compared to a population of 40 de novo PD patients.Results: Four BD patients had abnormal scans, but their clinical features and cumulative exposure to both antipsychotic drugs and lithium were similar to those of BD patients with normal dopamine transporter imaging. BD patients with pathological scans had putaminal binding ratio and putamen-to-caudate ratios higher than those of PD patients despite a similar motor symptom burden.Conclusions: Up to 20% of BD patients with parkinsonism might have an underlying dopaminergic deficit, which would not be due to cumulative exposure to offending drugs and is ostensibly higher than expected in the general population. This supports the evidence that BD represents a risk factor for subsequent development of neurodegenerative parkinsonism, the nature of which needs to be elucidated.
Determinants of Sleepiness at Wheel and Missing Accidents in Patients With Obstructive Sleep Apnea
Authors: Fanfulla Francesco , Pinna Gian Domenico , Marrone Oreste , D’Artavilla Lupo Nadia , Arcovio Simona , Bonsignore Maria R. , Morrone Elisa 
Published: April 2021

Study ObjectivesMotor-vehicle crashes are frequent in untreated OSA patients but there is still uncertainty on prevalence as well as physiological or clinical determinants of sleepiness at the wheel (SW) in OSA patients. We assessed determinants of SW or sleepiness related near-miss car accident (NMA) in a group of non-professional drivers with OSA.MethodsA 237 consecutive, treatment-naïve PSG-diagnosed OSA patients (161 males, 53.1 ± 12.6 years) were enrolled. Self-reported SW was assessed by positive answer to the question, “Have you had episodes of falling asleep while driving or episodes of drowsiness at wheel that could interfere with your driving skill in the last year?” Occurrence of NMA in the last 3 years was also individually recorded. Habitual self-reported average sleep time was collected.ResultsSW was found in 41.3% of patients but one-quarter of patients with SW did not report excessive daytime sleepiness. Predictors of SW were the following subjective factors: Epworth sleepiness scale score (ESS-OR 1.26; IC 1.1–1.4; p &lt; 0.0001), depressive symptoms (BDI-OR 1.2; IC 1.06–1.18; p &lt; 0.0001) and level of risk exposure (annual mileage-OR 1.9; IC 1.15–3.1; p = 0.007). NMAs were reported by 9.7% of patients, but more frequently by SW+ than SW– (22.4% vs. 0.7%; χ2 31, p &lt; 0.0001). The occurrence of NMAs was significantly associated to ESS, BDI, habitual sleep duration and ODI (R2 = 0.41).ConclusionSW is not predicted by severity of OSA. Evaluation of risk exposure, assessment of depressive symptoms, and reported NMA should be included in the clinical evaluation, particularly in patients with reduced habitual sleep time and severe nocturnal hypoxia.