bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Patient Disclosure of Cancer Diagnosis to the Family Dentist and Medical-dental Collaboration in Cancer Care
Authors: Lee Kyunghee , Takase Kozo , Fushimi Kiyohide 
Published: August 2021

Abstract
PurposeThis study was conducted to identify factors that are associated with whether cancer patients inform their family dentists about their cancer diagnosis.MethodsWe conducted a cross-sectional questionnaire study in 500 cancer patients (gastric, colorectal, lung, breast, and prostate cancer) from September 10 to 13, 2019. The factors influencing whether cancer patients report their cancer diagnosis to their family dentist were identified by multivariate logistic regression analysis.ResultsNearly half of the respondents (42.2%) informed their family dentist that they had cancer. The reporting behavior of cancer patients was distinctively associated with their physician’s advice (odds ratio [OR] 59.3; 95% confidence interval [CI] 7.7–456.3); 8.6% of all respondents received physician’s advice to inform their dentist about their cancer diagnosis. A good relationship with the family dentist was the most involved factor (OR 1.88; 95% CI 1.43–2.48) for reporting behavior in the group without physician's advice, whereas positive opinion of medical–dental collaboration in cancer care had little impact on the reporting behavior.ConclusionThe results of this study indicate the need for establishing an environment for cancer patients to receive appropriate oral care wherein physician’s advice and a good relationship with the family dentist are motivators for reporting a cancer diagnosis to the dentists. It is necessary to fully inform cancer patients about the benefits of medical–dental collaboration in cancer care.
Quantitative Evaluation of Encrustations in Double-J Ureteral Stents With Micro-computed Tomography and Semantic Segmentation
Authors: Zheng Shaokai , Amado Pedro , Kiss Bernhard , Stangl Fabian , Haeberlin Andreas , Sidler Daniel , Obrist Dominik , Burkhard Fiona , Clavica Francesco 
Published: August 2021

Abstract
Accurate evaluations of stent encrustation patterns, such as volume distribution, from different patient groups are valuable for clinical management and the development of better stents. This study compared stent encrustation patterns from stone and kidney transplant patients. Twenty-three double-J ureteral stents were collected at a single center from patients with stone disease or underwent kidney transplantation. Encrustations on stent samples were quantified by means of micro‑computed tomography and semantic segmentation using Convolutional Neural Network models. Luminal encrustation volume per stent unit was derived to represent encrustation level, which did not differ between patient groups in the first six weeks. However, stone patients showed higher encrustation levels over prolonged indwelling times (p = 0.036). Along the stent shaft body, the stone group showed higher encrustation levels near the ureteropelvic junction compared to the ureterovesical junction (p = 0.013), whereas the transplant group showed no such difference. Possible explanations were discussed regarding vesicoureteral refluxes. In both patient groups, stent pigtails were more susceptible to encrustations, and no difference between renal and bladder pigtail was identified. Our results suggest that excessively long stents with superfluous pigtails should be avoided.
Live imaging and conditional disruption of native vertebrate planar cell polarity
Authors: Jussila Maria , Boswell Curtis , Ciruna Brian 
Published: August 2021

Abstract
Tissue-wide coordination of polarized cytoskeletal organization and cell behaviour, critical for organ morphogenesis and tumour progression, is controlled by asymmetric membrane localization of non-canonical Wnt/planar cell polarity (PCP) signalling components. Understanding the dynamic regulation of PCP thus requires visualization of these core proteins. In vertebrates, immunohistochemical studies have provided snapshots of PCP within tissues while exogenous, fluorescently-tagged reporters have been introduced for live imaging of cell polarity. However, the functionality and spatiotemporal relevance of static and exogenous PCP readouts remain uncertain. Here we fluorescently tag an endogenous core PCP component, Vangl2, in zebrafish. We report on the authentic regulation of vertebrate PCP, through live imaging of this native sfGFP-Vangl2 protein during embryogenesis. We couple sfGFP-Vangl2 with conditional zGrad GFP-nanobody degradation methodologies for tissue-specific interrogation of PCP function. Together, our studies provide crucial insights into the establishment and maintenance of vertebrate PCP and create a powerful experimental paradigm for future investigations.
Role of Bio-based Synthesized Nano Zinc Oxide in Ameliorating the Deleterious Effects Caused by Lead in Vigna radiata L.
Authors: YADAV RAVI KUMAR , Singh Narsingh Bahadur , SINGH AJEY , YADAV VIJAYA , NIHARIKA KM , KHARE SHUBHRA , AZIM ZEBA 
Published: August 2021

Abstract
The present work describes the bio-based synthesis (green) and characterization of Zinc oxide nanoparticles (ZnO NPs) using leaf extract of Tridax, the synthesized nanoparticles were used to study their beneficial effect in the growth and metabolism of Vigna radiata. Zinc oxide nanoparticles (ZnONP) were characterized using X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), High-Resolution Transmission Electron Microscopy (HR-TEM), and Ultraviolet–visible spectroscopy (UV–Vis spectra). Growth of V. radiata seedlings was measured in terms of shoot length (SL) and root length (RL) were treated 20 and 40 mg/L concentrations of green synthesized ZnO NPs, and constant concentration (50 mg/L) of PbCl2. These studies have shown the effect of ZnO NPs in the stimulation of growth as well as physiological and biochemical parameters. Vigna seedlings showed positive effects depending upon the increasing concentrations of ZnO NPs. This study suggests that ZnO NPs can be effectively used to ameliorate the toxicity of Pb in Vigna plants.
Characteristics and Outcomes of Intracranial Hemorrhage in Cancer Patients Visiting the Emergency Department
Authors: Qdaisat Aiham , Yeung Sai-Ching , Hernandez Cristhiam M Rojas , Samudrala Pavani , Kamal Mona , Li Ziyi , Wechsler Adriana H. 
Published: August 2021

Abstract
Introduction: Intracranial hemorrhage is a devastating complication of cancer and its treatment.Objective: To evaluate the characteristic, risk factors and clinical outcomes in cancer patients with intracranial hemorrhage presenting to the emergency department. Methods: We collected a decade of retrospective data on all patients with the diagnosis of ICH who visited The University of Texas MD Anderson Cancer Center emergency department. Logistic regression analyses were used to determine the association between clinical variables and various outcomes.Results: 704 confirmed acute ICH cases were identified. Of these, 576 (81.8%) were spontaneous. In-hospital, 7-day, and 30-day mortality rates were 15.1%, 11.4%, and 25.6%, respectively. Hypertension was most predictive of prolonged hospital stay ( [OR]=4.77, 95% [CI]=1.30-22.70, P=0.045) and intensive care unit admission (OR=1.52, 95% CI=1.09-2.12, P=0.013). Low platelet count was associated with both in-hospital mortality (OR=0.96, 95% CI=0.94-0.99, P=0.008) and 30-day mortality (OR=0.98, 95% CI=0.96-1.00, P=0.016). Radiologic findings especially herniation and hydrocephalus, were strong predictors of short-term mortality. Patients with intratumor bleeding had substantially lower short-term mortality rates, but this did not reach statistical significance.Conclusions: Intracranial hemorrhage remains an uncommon complication in cancer patients. The risk factors most helpful in predicting outcomes were hypertension, low platelet count, and hydrocephalus or herniation on imaging.
The Impact of Obesity and Adiposity on Mortality Risk in Older Adults: A Ten-year Survival Analysis
Authors: Moura Letícia Almeida Nogueira , Pagotto Valéria , Pereira Cristina Camargo , Filho Rômulo Roosevelt da Silva , de Oliveira César , Silveira Erika Aparecida 
Published: August 2021

Abstract
There are not much information about the impact of obesity on all-cause, cardiovascular and cancer mortality in older adults. We have investigated the impact of obesity and adiposity on all-cause, cardiovascular and cancer mortality, in older adults after a 10-year follow-up. Prospective cohort study has been carried out with individuals ≥ 60 years. Sociodemographic characteristics, lifestyle, clinical history, laboratory tests and anthropometric data were collected. Adiposity was defined as tertiles of the percentage of body fat assessed by multifrequency bioimpedance. For obesity, three classifications were considered using the body mass index (BMI) as follows: ≥ 25.0 kg/m² in men and ≥ 26.6 kg/m² in women, ≥ 27.0 kg/m² and ≥ 30.0 kg/m². The BMI ≥ 30.0 kg/m² was associated a reduction in the all-cause mortality risk in non-ajusted Cox regression (HR: 0.65; 95% CI: 0.43 - 0.97) and in the Kaplan-Meier curves (p = 0.032). However, in multivariate Cox regression none of the diagnostic criteria for obesity and adiposity were significantly associated with all-cause, cardiovascular or cancer mortality. This 10-year survival analysis has showed that obesity and adiposity were not associated with an increased risk of all-cause, cardiovascular or cancer mortality in the older adults.
Bacillus Subtilis Spores as Delivery System for Nasal Plasmodium Falciparum Circumsporozoite Surface Protein Immunization in a Murine Model
Authors: de Almeida Maria Edilene M. , Alves Késsia Caroline Souza , de Vasconcelos Maria Gabriella Santos , Pinto Thiago Serrão , Glória Juliane Corrêa , Chaves Yury Oliveira , Neves Walter Luiz Lima , Tarragô Andrea Monteiro , Neto Júlio Nino de Souza , Filho Spartaco Astolfi , Pontes Gemilson Soares , Balieiro Antônio Alcirley da Silva , Isticato Rachele Isticato , Ricca Ezio , Mariúba Luis André M. 
Published: August 2021

Abstract
Malaria remains a widespread public health problem in tropical and subtropical regions around the world, and there is still no vaccine available for full protection. In recent years, it has been observed that spores of Bacillus subtillis can act as a vaccine carrier and adjuvant, promoting an elevated humoral response after co-administration with antigens either coupled or integrated to their surface. In our study, B. subtillis spores from the KO7 strain were used to couple the recombinant CSP protein of P. falciparum (rPfCSP), and the nasal humoral-induced immune response in Balb/C mice was evaluated. Our results demonstrate that the spores coupled to rPfCSP increase the immunogenicity of the antigen, which induces high levels of serum IgG, and with balanced Th1/Th2 immune response, being detected antibodies in serum samples for 250 days. Therefore, the use of B. subtilis spores appears to be promising for use as an adjuvant in a vaccine formulation.
Development and External Validation of a Nomogram for Neurosyphilis Diagnosis Among Non-HIV Patients: A Cross-sectional Study
Authors: Ge Wenjing , Zhang Yang , Peng Chao , Li Dongdong , Gao Lijie , Bao Jiajia , Li Changling , Chen Ning , Zhou Dong , He Li 
Published: August 2021

Abstract
Background: The diagnosis of neurosyphilis (NS) is challenging due to the requirement of a lumbar puncture and cerebrospinal fluid (CSF) tests. Methods: This cross-sectional study constructed diagnostic models for diagnosing NS with data gathered from the Western China Hospital of Sichuan University between September 2015 and April 2021 and Shangjin hospital between September 2019 and April 2021, which formed the development and validation cohorts, respectively. A logistic analysis was performed to predict reactive neurosyphilis diagnosis and was presented as a nomogram. Clinical usefulness of the diagnostic models was assessed using a receiver operating characteristic (ROC) curve analysis, and Harrell C index was used for discrimination and calibration plots for accuracy, adopting bootstrap resampling 500 times. Results: Overall, 149 and 67 patients were included in development and validation cohorts, respectively. Of those, 131 were diagnosed as having reactive NS with positive results in CSF treponemal and non-treponemal tests. In the development cohort, male sex, psychiatric symptoms, and serum toluidine red unheated serum test were selected as diagnostic indicators. The model reached 80% specificity, 79% sensitivity, and 0·85 area under the curves (AUC) (95% CI, 0·76-0·91). In the validation cohorts, the Harrell C index for the diagnostic possibility of reactive NS was 0·71. Conclusion: A convenient model using gender, presence of psychiatric symptoms and serum TRUST titre was developed and validated to indicate diagnostic results in patients suspected of NS. Checking model value of factors on nomogram is a feasible way to assist clinicians and primary health servers in updating patients’ medical chart and making quantitatively informed decision on NS diagnosis. Trial registration: This research was retrospectively registered in Ethics committee on biomedical research, West China Hospital of Sichuan University.
Low Methodological Quality of Systematic Reviews on Acupuncture: A Cross- Sectional Study
Authors: Ho Leonard TF , Ke Fiona YT , Wong Charlene HL , Wu Irene XY , Cheung Andy KL , Mao Chen , Chung Vincent CH 
Published: August 2021

Abstract
Background: While well-conducted systematic reviews (SRs) can provide best evidence on the potential effectiveness of acupuncture, limitations on methodological rigour of SRs may impact trustworthiness of their conclusions. This cross-sectional study aimed to evaluate the methodological quality of a representative sample of SRs on acupuncture effectiveness.Methods: CDSR, MEDLINE, and EMBASE were searched for SRs on acupuncture. AMSTAR2 was applied for assessing methodological quality. Associations between bibliographical characteristics and methodological quality ratings were examined. Results: A total of 106 SRs were appraised. Only one (0.9%) SR was of high overall methodological quality, zero (0%) was of moderate-quality, six (5.7%) and 99 (93.4%) were of low-quality and critically low-quality respectively. Among appraised SRs, only ten (9.4%) provided an a priori protocol, four (3.8%) conducted a comprehensive literature search, five (4.7%) provided a list of excluded study, and six (5.7%) performed meta-analysis appropriately. Cochrane reviews, update reviews, reviews with corresponding authors from the America, and reviews that searched non-English databases had relatively higher overall quality. Conclusions: Methodological quality of SRs on acupuncture is unsatisfactory. Future reviewers should improve critical areas of publishing protocols, performing comprehensive search, providing a list of excluded studies with justifications for exclusion, and conducting meta-analysis appropriately.
The Impact of Lockdown during COVID-19 Pandemic on Hip Fracture Cases in Austria
Authors: Oliver Malle , Wolfgang Brozek , Michael Szivak , Dimai Hans Peter 
Published: August 2021

Abstract
Mini AbstractSocial lockdowns may have an impact on fracture cases. During the first lockdown in Austria (March 16th to May 31st 2020), hip fracture cases did not significantly change, except a decreased rate in female patients aged 50-69 years.IntroductionSocial lockdown has been repeatedly imposed worldwide due to the coronavirus disease 2019 (COVID-19). Resultant isolation with less physical activity and restricted health care access may have an impact on fracture incidences. The aim of this analysis was to assess the effect of a social lockdown on hip fracture cases in Austria.MethodsThis analysis is based on the data of the Austrian Workers' Compensation Board (AUVA), which is the social insurance for the majority in Austria. Hip fracture cases in the time period March 16th to May 31st, 2020 (first lockdown period in Austria) were compared with those in the same period of previous years (2016-2019). Further analysis included stratification by gender, age and weekly intervals using repeated measures analysis of variance (ANOVA), while a p-value of less than 0.05 was considered statistically significant.ResultsIn the time period March 16th to May 31st 2020 the fracture cases of 445 lied within the standard deviation (SD) of years before (438 ± 20.1). The mean cases of weekly separated intervals in 2016-2019 did not differ significantly from those in 2020. In patients aged 50 to 69 years, the fracture cases in 2020 was below the SD of those in years before (64 vs. 77 ± 10). Stratified by weekly intervals and age group, mean fracture cases of years before were comparable with those of 2020, except 2018, which had significant lower rates in patients aged 50-69 years (p<0.05). Separated by gender, this difference was only seen in women.ConclusionHip fracture cases did not significantly change during first social lockdown (March 16th to May 31st 2020) in Austria, except a decreased fracture rate in female patients aged 50-69 years.
Preoperative Anemia Is A Predictor of Cacoethic Postoperative Outcomes Following Open Pancreatoduodenectomy – A Propensity Score-Based Analysis
Authors: Xu Jing-Yong , Tian Xiao-Dong , Yang Yin-Mo , Song Jinghai , Wei Jun-Min 
Published: August 2021

Abstract
Background: Preoperative anaemia is a common clinical situation that was proved to be associated with severe outcomes in major surgery but not pancreatic surgery alone. We aimed to study the impact of preoperative anaemia on morbidity and mortality in patients undergoing open pancreaticoduodenectomy by using propensity score matching (PSM) to balance the basal data and reduce bias. Methods: Consecutive patients undergoing open pancreaticoduodenectomy with complete record of preoperative haemoglobin at two pancreatic centers in China between 2015 to 2019 were analysed. Haemoglobin less than 12g/dl for male and 11g/dl for female were defined as anaemia in Chinese population. Clinical and economic outcomes were compared before and after propensity score matching (PSM). Logistic regression analysis was used to assess correlation between variables and anaemia. Results: The unmatched initial cohort consist of 517 patients. 148 cases (28.6%) were diagnosed as anaemia at admission, and no case received preoperative blood transfusion or anti-anaemia therapy. After PSM, 126 cases were in each group. The rate of severe postoperative complications was significantly higher in anaemia group than in normal group (43.7% versus 27.0%, P=0.006), among which prevalence of clinically relevant postoperative pancreatic fistula (31.0% versus 15.9%, P=0.005) and cardiac and cerebrovascular events (4.0% versus 0.0%, P=0.024) were most significant. It costed more in the anaemia group (26958.2±21671.9 versus 20987.7±10237.9 USD, P=0.013). Among all patients, multivariate analysis showed that preoperative obstructive jaundice [OR 1.813, 95%CI (1.206-2.725), P=0.004] and pancreatic ductal adenocarcinoma [OR 1.861, 95%CI (1.178-2.939), P=0.008] were predictors of anaemia. Among paired patients, preoperative anaemia [OR 2.593, 95%CI (1.481-5.541), P=0.001] and malignant pathology [OR 4.266, 95%CI (1.597-11.395), P=0.004] were predictors of postoperative severe complications.Conclusions: Preoperative anaemia is a predictor of cacoethic postoperative outcomes following open pancreatoduodenectomy and needs identified and treated.
Relationship Between The Appropriateness of Antibiotic Treatment and Clinical Outcomes of Patients With Community-Acquired Acute Pyelonephritis: A Multicenter Prospective Cohort Study
Authors: Yoon Choseok , Park Se Yoon , Kim Bongyoung , Kwon Ki Tae , Ryu Seong-yeol , Wie Seong-Heon , Jo Hyun-uk , Kim Jieun , Hong Kyung-Wook , Kim Hye In , Kim Hyun ah , Kim Mi-Hee , Bae Mi-Hyun , Sohn Yong-Hak , Kim Jieun , Lee Yangsoon , Pai Hyunjoo 
Published: August 2021

Abstract
Background

Inappropriate use of antibiotics not only increases antibiotic resistance as collateral damage but also increases clinical failure rates and medical costs. The purpose of this study was to determine the relationship between the appropriateness of antibiotic prescription and clinical outcomes of community-acquired acute pyelonephritis (CA-APN).
Methods

A multicenter prospective cohort study was conducted at eight hospitals in Korea between September 2017 and August 2018. All hospitalized patients aged ≥ 19 years who were diagnosed with CA-APN on admission were recruited. The appropriateness of empirical and definitive antibiotics, as well as the appropriateness of antibiotic treatment duration and route of administration, was evaluated. Clinical outcomes were compared between patients who were administered antibiotics ‘appropriately’ and ‘inappropriately.’
Results

A total of 397 and 318 patients were eligible for the analysis of the appropriateness of empirical and definitive antibiotics, respectively. Of them, 10 (2.5%) and 18 (5.7%) were administered ‘inappropriately’ empirical and definitive antibiotics, respectively. Of the 119 patients whose use of both empirical and definitive antibiotics was classified as ‘optimal,’ 57 (47.9%) received antibiotics over a longer duration than that recommended; 67 (56.3%) did not change to oral antibiotics on day 7 of hospitalization, even after stabilization of the clinical symptoms. Patients who were administered empirical antibiotics ‘appropriately’ had shorter hospitalization days (9 vs. 12.5 days, P = 0.014) and lower medical costs (2,332.7 vs. 4,531.2 USD, P = 0.007) than those who were administered them ‘inappropriately.’ Similar findings were observed for patients administered both empirical and definitive antibiotics ‘appropriately’ and those administered either empirical or definitive antibiotics ‘inappropriately’
Conclusions

Appropriate use of antibiotics leads to better clinical outcomes, including reduced hospitalization duration and medical costs.
Impact of the COVID19 pandemic on the implementation of Health Information Technologies (HIT): a case study in Maternity Hospital of Lubango-Angola
Authors: Sanjuluca Tomas Hambili Paulo , Cruz-Correia Ricardo , Almeida Anabela Antunes 
Published: August 2021

Abstract
Background

COVID19 pandemic has shown the importance of data to manage health crises. Therefore, countries that were more mature regarding using Information Systems (IS) were better prepared to respond to their population needs. Unfortunately, in Angola, such Health Information Systems (HIS) maturity is very low, so new Health Information Technology (HIT) projects must change this scenario.
Objective

Describe the impact of COVID19 on a new health information technology project called "ObsCare Lubango" to collect essential data on deliveries and births at the Maternity Hospital in Lubango-Angola.
Methods

Retrieve data from the notes, communication events of the project management. Also, the collected data regarding obstetrics (pregnancies and childbirth) was from Jan 2019 to Apr 2021 (14 months before COVID19 and 14 months after the beginning of COVID19). The data analyzed were collected from the utilization audit trail that stores the sessions and clicks in the application logs. These logs are then presented in aggregated and anonymized form in a web interface.
Results

The start of COVID19 in Maternity halted the evolution of the health information project implementation. At the beginning of 2020, the usage of ObsCare Lubango was growing steadily (5.9%, 7.5%, 9.4% in the first three months), but rapidly dropped to 0% in the following months after the first of COVID arrived in late March.
Conclusion

COVID19 had a significant impact on the evolution of ObsCare Lubango and heavily impacted the quality of the data collected in the paper. COVID19 will probably increase the digital divide in health care between nations.