bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parametric study and optimization on novel fork‐type mini‐channel network cooling plates for a Li‐ion battery module under high discharge current rates
Authors: Li Qing , Shi Hang‐bo , Xie Gongnan , Xie Zhongliang , Liu Huan‐ling 
Published: June 2021

SummaryWhen a lithium‐ion battery works under high current, its working temperature is easy to exceed the allowable working temperature, resulting in the decrease of battery life. This may cause the non‐uniformity of the internal working temperature of the battery and affect the working parameters of the battery. Therefore, an effective thermal management system is needed to enhance the thermal performance of the battery, improve the work efficiency, and extend the service life of the battery. In this study, we propose a new type of fork type mini‐channel cooling plate based on genetic optimization algorithm to reduce the working temperature of battery and obtain better thermal uniformity. First, the thermal performance of co‐current type cooling plates is experimentally and numerically studied. The heat transfer ability of cross flow cooling plates used to cool the Li‐ion Battery is evaluated by parametric method. Second, a multi‐objective genetic algorithm optimization is finally performed, considering the balance of the maximum value for temperature and pressure drop. Compared with the previous study, the reduction of temperature difference of this cooling plate can be up to 2°C. In contrast, the pressure drop penalty and thermal resistance of the optimized cooling plates can be reduced by 20% and 40%, respectively. Thirdly the thermal performance of a battery module with eight battery cells is also examined numerically. The maximum ∆T of the battery pack among cells is 4.83°C for V = 48 mL/s, which implies that the battery pack can work normally. This study indicates that batteries with the proposed new cooling plates have much better temperature uniformity.
Long‐term antipsychotic use and cognitive decline in community‐dwelling older adults with mild–moderate Alzheimer disease: Data from NILVAD
Authors: Dyer Adam H. , Murphy Claire , Lawlor Brian , Kennelly Sean P. , for the NILVAD Study Group  
Published: June 2021

AbstractIntroductionPrevious evidence has suggested that antipsychotic use may be associated with accelerated cognitive decline in those living with dementia. However, the cognitive effects of long‐term antipsychotic use in community‐dwelling older adults with mild–moderate Alzheimer disease (AD) has not been explored to date.MethodsWe assessed the impact of long‐term antipsychotic use on the rate of cognitive decline (Alzheimer’s Disease Assessment Scale—Cognitive Subsection) and dementia progression (Clinical Dementia Rating—Sum of Boxes [CDR‐Sb]/Disability Assessment for Dementia [DAD]) over 18 months in older adults with mild–moderate AD.ResultsOf 509 participants with mild–moderate AD, one‐tenth (54/509; 10.6%) were prescribed an antipsychotic for the 18‐month study duration. Antipsychotic use was significantly associated with accelerated cognitive decline at both 12 (β: 3.53, 0.91–6.17, p = 0.008) and 18 months (β: 3.81, 0.49–7.14, p = 0.024) in addition to greater dementia progression at both 12 (β: 1.85, −0.97–2.73, p < 0.001 for CDR‐Sb/β: −3.33, −5.56–1.10, p = 0.003 for DAD) and 18 months (β: 1.41, 0.16–2.67, p = 0.027 for CDR‐Sb/β: −3.86, −6.64 to −1.08, p = 0.006 for DAD). APOE ε4 carriers experienced significantly greater cognitive decline with long‐term antipsychotic use.ConclusionsLong‐term antipsychotic use was associated with greater cognitive decline and dementia progression in community‐dwelling older adults with mild–moderate AD. Our findings are consistent with previous evidence encouraging cautious and careful consideration of risks versus benefits of antipsychotic usage in those with AD.
A unified framework to account for selective mortality in lifecycle analyses of the social gradient in health
Authors: Allanson Paul , Petrie Dennis 
Published: June 2021

AbstractThis paper establishes a unified framework to fully account for the changing social gradient over the lifecycle in terms of a sufficient set of mobility indices characterizing the coevolution of socioeconomic status and health within each of a series of overlapping cohorts. We proceed to demonstrate the impact of selective mortality on health inequality changes, making use of a counterfactual health distribution for the start of the study period that leaves out those who are known to die before the end. Specifically, initial differences between the average health and educational attainment rank of survivors and nonsurvivors are found in our empirical study to be an increasingly important factor explaining changes in the education‐health gradient in older cohorts in Great Britain. Our identification strategy has the advantage that it does not require the imputation of the “would be” health of nonsurvivors, which if carried out using inverse probability weighting procedures—as in several previous studies—is shown to bias estimates of this direct effect of selective mortality toward zero. Parallel results for the income‐health gradient exhibit stronger confounding influences due to a number of other factors given that income is a less stable indicator of socioeconomic status in adulthood.
Adult‐born neurons promote cognitive flexibility by improving memory precision and indexing
Authors: Berdugo‐Vega Gabriel , Lee Chi‐Chieh , Garthe Alexander , Kempermann Gerd , Calegari Federico 
Published: June 2021

AbstractAdult neurogenesis in the hippocampal dentate gyrus (DG) is an extraordinary form of plasticity fundamental for cognitive flexibility. Recent evidence showed that newborn neurons differentially modulate input to the infra‐ and supra‐pyramidal blades of the DG during the processing of spatial and contextual information, respectively. However, how this differential regulation by neurogenesis is translated into different aspects contributing cognitive flexibility is unclear. Here, we increased adult‐born neurons by a genetic expansion of neural stem cells and studied their influence during navigational learning. We found that increased neurogenesis improved both memory precision and flexibility. Interestingly, each of these gains was associated with distinct subregional patterns of activity and better separation of memory representations in the DG‐CA3 network. Our results highlight the role of adult‐born neurons in promoting memory precision and indexing and suggests their anatomical allocation within specific DG‐CA3 compartments, together contributing to cognitive flexibility.
Harmonized edge/graphitic‐nitrogen doped carbon nanopolyhedron@nanosheet composite via salt‐confined strategy for advanced K‐ion hybrid capacitors
Authors: Yi Yuyang , Ma Hao , Lian Xueyu , Mei Qingqing , Zeng Zhihan , Zhao Yu , Lu Chen , Zhao Wen , Guo Wenyue , Liu Zhongfan , Sun Jingyu 
Published: June 2021

AbstractNitrogen doping has readily emerged as an efficient solution to boost potassium‐ion storage of carbonaceous materials. Nevertheless, the capacity and lifespan enhancement of derived electrodes is still plagued by the incompetent in coordinating the dopant configurations. In the realm of emerging potassium‐ion hybrid capacitor (PIHC) device, dictating nitrogen doping to enhance pseudocapacitive behavior and improve K+ diffusion kinetics of carbonaceous anodes is scarcely demonstrated. Herein, we report the design of hierarchical N‐doped carbon nanopolyhedron@nanosheet composite via a salt‐confined synthetic strategy with tunable doping configurations toward advanced PIHC anode. A harmonized edge‐ to graphitic‐nitrogen ratio in such dual‐carbon materials enables outstanding rate capability (130 mAh g−1 at 10.0 A g−1) and cyclic performance (with a capacity retention of 80% after 2000 cycles at 5.0 A g−1) in half‐cell tests. As expected, the thus‐assembled PIHC full device with a working voltage of 4.2 V presents a high energy/power density (146 Wh kg−1/8000 W kg−1) and favorable cyclicability. This work is anticipated to offer an innovative insight into the coordination of nitrogen doping configurations in heteroatom‐doped carbon anode targeting high‐performance PIHC applications.image
The mechanism research on the anti‐liver fibrosis of emodin based on network pharmacology
Authors: Liang Baoyu , Gao Liyuan , Wang Feixia , Li Zhanghao , Li Yujia , Tan Shanzhong , Chen Anping , Shao Jiangjuan , Zhang Zili , Sun Lixia , Zhang Feng , Zheng Shizhong 
Published: June 2021

AbstractAimsThis study was designated to illustrate the underlying mechanisms of emodin anti‐liver fibrosis via network pharmacology and experiment.MethodsThe TSMCP and Genecards database were applied to screen the relevant targets of emodin or liver fibrosis. The essential target was selected by using Cytoscape to analyze the topological network of potential targets. Furthermore, we constructed a preliminary molecule docking study to explore the binding site by Surflex‐Dock suite SYBYL X 2.0. The DAVID database was selected for gene functional annotations and KEGG enrichment analysis. Moreover, we demonstrated the ameliorating effect of emodin on carbon tetrachloride (CCl4)‐induced liver injury in mice. We also verified the network predictions in vitro via various techniques.ResultsThe collected results showed that 35 targets were related to emodin, and 6,198 targets were associated with liver fibrosis. The Venn analysis revealed that 17 intersection targets were correlated with emodin anti‐liver fibrosis. The topological network analysis suggested that the p53 was the remarkable crucial target. Besides, the molecule docking results showed that emodin could directly interact with p53 by binding the active site residues ASN345, GLN331, and TYR347. Finally, KEGG pathway enrichment results indicated that essential genes were mainly enriched in mitogen‐activated protein kinase (MAPK) signaling pathways. Moreover, our study confirmed that emodin alleviated CCl4‐induced liver injury in mice, inducing hepatic stellate cells (HSCs) apoptosis via regulating the p53/ERK/p38 axis.ConclusionsThis study partially verified the network pharmacological prediction of emodin inducing HSCs cell apoptosis through the p53/ERK/p38 axis.
Disruption of Jmjd3/p16Ink4a Signaling Pathway Causes Bizarre Parosteal Osteochondromatous Proliferation (BPOP)-like Lesion in Mice
Authors: Zhang Feng , Wang Yingmei , Wang Yuying , Wang Xinli , Zhang Dawei , Zhao Xiong , Jiang Runmin , Gu Yu , Yang Guifang , Fu Xin , Xu Longyong , Xu Longxia , Zheng Liting , Zhang Jing , Li Zengshan , Yan Qingguo , Shi Jianguo , Roessner Albert , Wang Zhe , Li Qing , Ye Jing , Chen Charlie Degui , Guo Shuangping , Min Jie 
Published: June 2021

ABSTRACT
Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare benign osteochondromatous lesion. At present, the molecular etiology of BPOP remains unclear. JMJD3(KDM6B) is an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression. Previously, Jmjd3 was shown to be critical for bone development and osteoarthritis. Here, we report that conditional deletion of Jmjd3 in chondrogenic cells unexpectedly resulted in BPOP-like lesion in mice. Biochemical investigations revealed that Jmjd3 inhibited BPOP-like lesion through p16Ink4a. Immunohistochemistry and RT-qPCR assays indicated JMJD3 and p16INK4A level were significantly reduced in human BPOP lesion compared with normal subjects. This was further confirmed by Jmjd3/Ink4a double-gene knockout mice experiments. Therefore, our results indicated the pathway of Jmjd3/p16Ink4a may be essential for the development of BPOP in human. © 2021 American Society for Bone and Mineral Research (ASBMR).
Serum osteoprotegerin level in hemodialysis patients using low‐flux reused dialyzer in relation to atherosclerosis
Authors: Do Van Tung , Nguyen Minh Tuan , Dao Bui Quy Quyen , Pham Quoc Toan , Nguyen Duy Toan , Nguyen Trung Kien , Nguyen Cong Hoang , Le Thi Huong Lan , Bui Thi Thu Huong , Tran Viet Tien , Do Quyet , Can Van Mao , Le Viet Thang 
Published: June 2021

AbstractAimsTo assess the relation of high serum OPG level and carotid atherosclerosis in maintenance hemodialysis (MHD) patients using low‐flux reused dialyzer.Materials and MethodsWe examined 209 MHD patients with and without carotid atherosclerosis (83 patients and 126 patients) to establish the relation between OPG and atherosclerosis.ResultsThe proportion of carotid atherosclerosis was 39.7%. The median serum OPG level was 45.3 pmol/L. Serum OPG had a good predicting value for atherosclerosis in MHD patients using low‐flux reused dialyzer (AUC = 0.934, p < 0.001, cutoff value = 43.35 pmol/L, Se = 81.3%, Sp = 90.9%).ConclusionsIn this study, serum OPG had a good predicting value for atherosclerosis in MHD patients using low‐flux reused dialyzer.
Organizational partnerships for a trauma‐informed community: A community‐wide social network study
Authors: King Lindsey M. , LeBeau Kelsea , Hart Mark , Vacca Raffaele 
Published: June 2021

AbstractWe investigated whether Peace4Tarpon's trauma‐responsive community capacity activities led to greater collaboration among community partners. We conducted longitudinal social network analysis (SNA) among organizations within Peace4Tarpon's network in 2016 and 2018 to capture cooperation around adverse childhood experiences‐related topics. We examined network structure, cohesion, organizational collaboration, and associations between centrality and organizational practices. Peace4Tarpon's network included diverse sectors, with a group of organizations forming the network core and collaborating over time. The network displayed a small increase in cohesion, more cross‐sector collaboration, and less heterophily over time. We found a significant difference between the mean betweenness centralities of organizations who assessed resilience and those who did not in the 2018 average union network. This is one of the first studies using SNA to investigate a trauma‐informed community network. Findings from this type of analysis may assist community organizations in strengthening outreach and strategically engaging organizations within a trauma‐informed network.
Retrospective study of peptide receptor radionuclide therapy for Japanese patients with advanced neuroendocrine tumors
Authors: Kobayashi Noritoshi , Wild Damian , Kaul Felix , Shimamura Takeshi , Takano Shoko , Takeda Yuma , Okubo Naoki , Suzuki Akihiro , Tokuhisa Motohiko , Ichikawa Yasushi 
Published: June 2021

AbstractBackgroundPeptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs is an innovative treatment for advanced somatostatin‐positive neuroendocrine tumors (NETs). PRRT cannot be performed in Japan because there is no approval or insurance cover so far.MethodsWe relied on foreign institutions to perform PRRT for Japanese patients with NETs. We retrospectively evaluated the safety and efficacy of PRRT. The inclusion criteria were pathologically confirmed well‐differentiated NET and visible tumor uptake on pre‐therapeutic somatostatin receptor scintigraphy. 177Lu‐DOTA‐TOC was used as the standard treatment, and patients received three infusions every 8 weeks. Until the end of 2017, combination treatment with 90Y and 177Lu‐DOTA‐TOC was performed using the same protocol.ResultsThirty‐five patients were evaluated, and the primary lesions were pancreas, rectum, small intestine, stomach, and other locations. The partial response rate was 42.9%. Progression‐free survival (PFS) was 12.8 months and overall survival was 42.8 months. There was no significant difference in PFS between front‐line and late‐line PRRT (11.0 months vs 28.0 months; P = .383). Severe adverse events included lymphocytopenia (20.0%) and thrombocytopenia (5.7%). Myelodysplastic syndrome occurred in one case.ConclusionPRRT was effective and safe for Japanese patients with advanced NETs. PRRT was equally effective as front‐line and late‐line treatment.
Reducing the risk of developing walled‐off necrosis in patients with acute necrotic collection using recombinant human soluble thrombomodulin
Authors: Eguchi Takaaki , Tsuji Yoshihisa , Okada Akihiko , Inoue Dai , Tokumasu Hironobu , Iwane Kosuke , Nakai Yoshitaka , Kusaka Toshihiro , Uenoyama Yoshito , Fujita Koichi , Yokode Masataka , Yamashita Yukimasa , Sawai Yugo , Asada Masanori , Mikami Takao , Kawanami Chiharu , Kudo Yasushi , Yazumi Shujiro , Sanuki Tsuyoshi , Sakai Arata , Morita Toshihiro , Sakuma Yojiro , Uza Norimitsu , Takada Yutaka , Itani Toshinao , Kuriyama Katsutoshi , Matsumura Kazuyoshi , Ikeda Kazuki , Someda Hitoshi , Funatsu Eiji , Katsushima Shinji , Kodama Yuzo , Seno Hiroshi 
Published: June 2021

AbstractBackground/PurposeThe purpose of the present study was to investigate the possibility of reducing clinical impacts of acute necrotic collection (ANC) on patients with acute pancreatitis (AP) using recombinant human soluble thrombomodulin (rTM).MethodsIn this retrospective multicenter study, 233 consecutive AP patients with ANC and acute peripancreatic fluid collection (APFC) from 2012 to 2016 were enrolled. To assess clinical impacts of ANC, severity on admission (JPN score, JPN CT grade, and Modified CT severity index), development of walled‐off necrosis (WON), imaging costs for follow‐up, and mortality were recorded. Finally, we investigated whether rTM could reduce the clinical impacts, adjusting the severity using propensity analysis with Inverse probability of treatment weighting.ResultsPatients with ANC developed WON with higher ratio than APFC (58/98 [59.2%] vs 20/135 [14.8%], OR = 8.3, P < .01]. Severity on admission and imaging costs for follow‐up in ANC patients were significantly higher than those in APFC (P < .01). However, regarding mortality, there was no significant difference between patients with ANC and APFC (P = .41). Adjusting severity, it was revealed that rTM administration significantly reduced the risk of ANC developed WON (OR = 0.23, P = .01).ConclusionsWhile ANC had a higher clinical impact than that of APFC, we found that early administration of rTM may reduce the impact.
Retrospective SARS‐CoV‐2 IgG screening during the first wave (March–June 2020) of the COVID‐19 pandemic in the United Kingdom
Authors: Bird Paul William , Sandhu Kyran , Fletcher Oliver , Ames Billy , Toovey Oliver , Tang Julian Wei‐Tze 
Published: June 2021

AbstractDuring the “first wave” of the coronavirus disease 2019 (COVID‐19) pandemic in the United Kingdom (March–June 2020), the city of Leicester was particularly hard hit, resulting in reimposed lockdown measures. Although initial polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was attempted within the community, testing was soon abandoned due to an inability to keep up with demand by local laboratories. It is therefore feasible that undiagnosed transmission of COVID‐19 in the community by asymptomatic individuals was a real possibility. Therefore, retrospective SARS‐CoV‐2 immunoglobulin G (IgG) testing of archived sera from out‐patients visiting University Hospitals of Leicester NHS Trust service was performed to investigate the transmission of SARS‐CoV‐2 in the community. A total of 1779 sera samples were tested from samples collected between 16th March and 3rd June 2020, of which 202 (11.35%) were SARS‐CoV‐2 IgG positive. Positivity was lowest in March (2.54%) at the beginning of the pandemic before peaking in April (17.16%) before a decline in May and June (11.16% and 12.68%, respectively). This retrospective screening offers some insight into the early patterns of SARS‐CoV‐2 transmission within a sampled community population during the first wave of the COVID‐19 pandemic; supporting the argument for more community screening during high incidences of pandemics.
Assessment of parametric approaches to calculate the Evaporative Demand Drought Index
Authors: Noguera Iván , Vicente‐Serrano Sergio M. , Domínguez‐Castro Fernando , Reig Fergus 
Published: June 2021

AbstractThe Evaporative Demand Drought Index (EDDI), based on atmospheric evaporative demand, was proposed by Hobbins et al. (2016) to analyse and monitor drought. The EDDI uses a nonparametric approach in which empirically derived probabilities are converted to standardized values. This study evaluates the suitability of eight probability distributions to compute the EDDI at 1‐, 3‐ and 12‐month time scales, in order to provide more robust calculations. The results showed that the Log‐logistic distribution is the best option for generating standardized values over very different climate conditions. Likewise, we contrasted this new parametric methodology to compute EDDI with the original nonparametric formulation. Our findings demonstrate the advantages of adopting a robust parametric approach based on the Log‐logistic distribution for drought analysis, as opposed to the original nonparametric approach. The method proposed in this study enables effective implementation of EDDI in the characterization and monitoring of droughts.
Reduced calf circumference is an independent predictor of worse quality of life, severity of disease, frequent exacerbation, and death in patients with chronic obstructive pulmonary disease admitted to a pulmonary rehabilitation program: A historic cohort study
Authors: Bernardes Simone , Silva Flávia Moraes , da Costa Cassia Cinara , de Souza Rafael Machado , Teixeira Paulo José Zimermann 
Published: June 2021

BackgroundMuscle wasting is associated with worse outcomes in chronic obstructive pulmonary disease (COPD) patients. We assessed the association of calf circumference (CC) measurements with clinical outcomes in COPD patients referred to an outpatient pulmonary rehabilitation program (PRP).MethodsIn this single‐center, retrospective study, we analyzed demographic and clinical data ( spirometry tests, comorbidities, COPD exacerbations, dyspnea scoring, exercise capacity, quality‐of‐life scores, BMI, CC measurements, and all‐cause deaths [for 2 years]) from COPD patients PRP medical records. Patients were grouped according to CC into reduced CC (male, ≤34 cm; female, ≤33 cm) or adequate CC groups.ResultsWe evaluated 144 patients (aged 64.6 ± 8.5 years; mostly males; forced expiratory volume in 1 s, 40.3% ± 15.8%, predicted). Eighteen patients (12.5%) died during the 2 years of follow‐up. Logistic regression showed that patients with reduced CC were more likely to present worse outcomes compared with COPD patients with adequate CC: more advanced disease severity (odds ratio [OR] = 5.09; 95% CI, 2.00–12.96), COPD frequent exacerbators (OR = 2.34; 95% CI, 1.11–4.91), worse total quality‐of‐life score (OR = 2.70, 95% CI, 1.22–6.00), and higher mortality (OR = 3.69; 95% CI, 1.06–12.87).ConclusionReduced CC in COPD patients under initial assessment for PRP admission was associated with disease severity, frequent exacerbation, poor health status, and higher mortality in 2 years of follow‐up. Considering its clinical applicability, CC measurement should be introduced in the nutrition assessment of COPD patients admitted to the PRP.