bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-center Retrospective Analysis of One-stop Hybrid Surgery for Brain Arteriovenous Malformations
Authors: Ma Yihui , Wang Lesheng , Shi Jichun , Dong Lixin , Zhang Tingbao , Feng Yu , Gong Yan , Chen Xinjun , Zhao Wenyuan , Chen Jincao 
Published: October 2021

Abstract
Objectives To evaluate the safety and effectiveness of one-stop hybrid surgery of microsurgical resection combined with preoperative embolization or intraoperative angiography for brain arteriovenous malformations (bAVMs) and compare the efficacy of one-stop hybrid surgery with nonhybrid surgery (endovascular embolization alone) in the treatment of bAVMs. Methods A single-center retrospective study was performed to recruit 70 patients with bAVMs at our hospital between July 2017 and April 2020. Patients were divided into 2 groups depending on the mode of surgery: hybrid group (i.e., microsurgical resection combined with preoperative endovascular embolization or intraoperative angiography in the hybrid operating room), and nonhybrid group (i.e., endovascular embolization, stereotactic radiosurgery, or microsurgical resection alone). The hybrid group was divided into two subgroups: the microsurgical resection combined with preoperative embolization, and the microsurgical resection combined with intraoperative angiography subgroups. All patients’ demographic variables, clinical manifestations, and imaging features, postoperative complications, and long-term clinical prognosis were recorded and analyzed. Results Among 70 patients, 48 (68.6%) of whom presented cerebral hemorrhage due to bAVMs rupture. 36 (51.4%) patients in the hybrid group were treated with the combination of pre-operative embolization or intraoperative angiography combined with microsurgical resection, whereas 34 (48.6%) in the nonhybrid group underwent embolization alone. There was no statistical difference in gender, age, ruptured bAVM rate, Spetzler-Martin grades between the 2 groups. Regular clinical and radiological follow-up examinations cure rates were 94.4% in the hybrid group compared to 38.3% in the nonhybrid group (P<0.01). The percentage of patients with favorable outcomes was 94.1% in the hybrid group and 90.6% in the nonhybrid group, although this difference was not statistically significant. Conclusions One-stop hybrid surgery could be a safe and effective intervention to treat bAVMs clinically, whereas further follow-up is needed to determine the long-term effects after operation.
Modelling and Optimization of Photovoltaic Serpentine Type Thermal Solar Collector With Thermal Energy Storage System For Hot Water and Electricity Generation For Single Residential Building
Authors: Baskaran Srimanickam , Satchi Christopher Sathiya , Amirtharajan Saranya , Durai Metilda Manuel Swami 
Published: October 2021

Abstract
Increasing surface temperature significantly affects the electrical performance of photovoltaic (PV) panels. A closed-loop forced circulation serpentine tube design of cooling water system is used to effectively manage the surface temperature of PV panels. A real-time experiment was first carried out with a PV panel with a cooling system at HTF flow rates of 60 kg h-1, 120 kg h-1, and 180 kg h-1. Based on the experimentation, a correlation for a nominal operating cell temperature (NOCT) and thermal efficiency for collector was developed for experimental validation of useful energy gained, cell temperature and electric power generation. The developed corrections are validated with electrical power and useful energy gained in photovoltaic serpentine thermal solar collector (PV/STSC) and fit into experimental results with a deviation of 1% and 2.5 % respectively. Further, with the help of developed correlations, a system was developed in the TRNSYS tool through which an optimization study was performed based on electric and hot water demand. The findings indicate that an optimal system with an 8 m2 PV/STSC area, a HTF flow rate of 60 kg h-1, and TES system having a volume and height of 280 l and 0.8 m could meet 91 % and 33 % of the hot water demand for Ac loads and 78 % or DC loads, respectively.
Physical activity and screen time in Australian Outside School Hours Care: current versus best practice
Authors: Virgara Rosa , Phillips Anna , Lewis Lucy , Richardson Mandy , Maher Carol 
Published: October 2021

Abstract
Background

Outside school hours care (OSHC) is accessed by millions of children internationally. Recently, physical activity and screen time guidelines in OSHC were developed. This study described the current physical activity and screen time scheduling in Australian OSHC, obtained sector feedback on the guidelines and compared current- with best-practice.
Methods

A cross-sectional online survey was administered to n=3551 Australian OSHC directors. Participants reported scheduling for physical activity and screen time opportunities in before- and after-school care. Feedback was sought on the new guidelines, including barriers and enablers for implementation. Scheduling data were used to evaluate whether services were currently meeting the new guidelines.
Results

566 directors participated. Physical activity and screen time practices varied widely (e.g. after-school physical activity opportunity ranged from 15 minutes to 150 minutes, mean 74, SD 28; after-school screen time opportunity ranged from 15 to 195 minutes, mean 89, SD 43), with state (p=0.002) and socioeconomic (p<0.001) differences. Most participants were supportive of the guideline’s recommended physical activity and screen time durations. Three in five OSHC services did not currently meet the guidelines.
Conclusions

Physical activity and screen time scheduling in OSHC is highly variable. Current practice in the majority of OSHC services does not meet best practice guidelines.
Two Fungal Flavonoid-specific Glucosidases/rutinosidases for Rutin Hydrolysis and Rutinoside Synthesis Under Homogeneous and Heterogeneous Reaction Conditions
Authors: Kotik Michael , Javůrková Hana , Brodsky Katerina , Pelantová Helena 
Published: October 2021

Abstract
The glycosidases within GH5-23 cleave the glycosidic bond of β-glucosylated or rutinosylated flavonoids. Moreover, by virtue of their transglycosylation activity, glycoconjugates with glucosyl and rutinosyl moieties are accessible. Here we report the biochemical characterization and biotechnological assessment of two heterologously expressed members of GH5-23 – McGlc from Mucor circinelloides and PcGlc from Penicillium chrysogenum. Both enzymes exhibited the highest hydrolytic activities with quercetin-3-β-O-glucopyranoside, whereas lower specificity constants were determined with the rutinosides narcissin, rutin and hesperidin. High stabilities against thermal, ethanol and dimethyl sulfoxide-induced inactivation, a very limited secondary hydrolysis of the formed transglycosylation products, and no detectable product inhibition were additional features appropriate for biotechnological applications. The enzymes were compared in their efficiencies to hydrolyze rutin and to synthesize 2‑phenylethyl rutinoside under homogeneous and heterogeneous reaction conditions using high rutin concentrations of 100 and 300 mM. Highest transglycosylation efficiencies were achieved with fully dissolved rutin in reaction mixtures containing 25 % dimethyl sulfoxide. Molecular docking and multiple sequence alignments suggest that the hydrophobic environment of aromatic residues within the +1 subsite of GH5-23 glycosidases is very important for the binding of flavonoid glucosides and rutinosides.
Prevalence and Correlates of Suicide Attempts in High-Risk Populations: A Cohort study among patients receiving opioid Agonist Therapy in Norway
Authors: Vold Jørn Henrik , Løberg Else-Marie , Aas Christer F. , Steier Jan Alexander , Johansson Kjell Arne , Fadnes Lars Thore 
Published: October 2021

Abstract
Background

Death by suicide in patients enrolled in opioid agonist therapy (OAT) is a major clinical concern. However, little knowledge exists regarding suicide attempts in this patient group. This study presents the lifetime prevalence of suicide attempts and the associations between suicide attempts and clinical and sociodemographic variables such as education, sex, early onset of substance use (< 13 years of age), substance use patterns, and injecting substance use among patients receiving OAT.
Methods

We used data from a cohort of OAT patients in Norway obtained from a health assessment of self-reported suicide attempts and sociodemographic and clinical factors. A total of 595 patients receiving OAT were assessed from 2016 to 2020. A binary logistic regression analysis was performed and reported with an unadjusted odds ratio and 95% confidence intervals (OR). The purpose of this assessment was to analyze associations between suicide attempts and substance use patterns as well as the injection of substances during the 30 days leading up to the health assessment. A negative binomial regression analysis with an incidence rate ratio and 95% confidence intervals (IRR) was performed to investigate sex, education, early onset of substance use, and the number of suicide attempts.
Results

Forty-one percent of the OAT patients had attempted to die by suicide at least once during their lifetime. An early onset of substance use was strongly associated with the suicide attempts (IRR: 1.7, 1.3–2.2). No significant association was found between suicide attempts and sex (IRR: 1.2, 0.9–1.6) or education (IRR: 0.6, 0.2–2.1). Likewise, no association was identified between suicide attempts and injecting substance use (OR: 0.9, 0.6–1.3), nor using alcohol (OR: 0.9, 0.7–1.3), amphetamines (OR: 1.0, 0.7–1.3), benzodiazepines (OR: 1.0, 0.7–1.4), cannabis (OR: 1.2, 0.9–1.7), cocaine (OR: 1.3, 0.6–3.0), or opioids (OR: 1.4, 0.9–2.0).
Conclusion

The lifetime prevalence of suicide attempts was alarmingly high in the OAT population. An early onset of substance use seemed to be an important risk factor for suicide attempts. Multiple actions are needed to prevent premature deaths by suicide in this high-risk population, and these include: health policies to prevent suicides, research on efficacy of suicide prevention interventions and clinical precision in management of patients with a high risk of suicide.
An assessment of organisational culture in Australian hospitals using employee online reviews
Authors: Pavithra Antoinette , Westbrook Johanna 
Published: October 2021

Abstract
Background
Online reviews on job sites have been used as a source of information about organisational culture in industries such as hospitality and technology. An extension of this approach by applying thematic analysis to online reviews posted by healthcare employees could potentially identify areas for organisational improvement in relation to enhancing employees’ wellbeing and experience. The aim of this study was to analyse the content of online reviews posted by hospital employees on job websites for themes of organisational culture.
Methods
103 anonymous online reviews across three job websites, posted by hospital employees of four hospitals within an Australian health network were extracted. Reviews had been posted across a period of six years, from 2014 to early 2020. Sentiment rating based on user-allotted ratings on the selected websites was calculated. The sentiment score was validated against the textual content of the review to confirm employee recommendation and sentiment. Sentiment was coded as neutral, positive, or negative. Significant keywords, associations, and usage within the context of identified sentiment were coded and clustered manually against eight pre-determined safety culture themes. These themes were derived from the most used assessment tools for self-reported measures of occupational health and safety, and safety culture in healthcare.
Results
Workers across clinical roles (n=49) and non-clinical roles (n=50) were evenly represented in the dataset. 35.9% of commenters (n=37) reported their length of employment in the hospitals that they reviewed. Most online employee reviews addressed broad themes related to perceptions of management (n=98), safety climate (n=97), teamwork climate (n=91) and working conditions (n=98). A significant set of reviews addressed themes related to job satisfaction (n=49) and learning, training, and development (n=41). 72.8% of online reviews (n=75) expressed positive sentiment towards their employer. Reviews expressing negative sentiment were largely posted by former employees and indicated areas of discontent that reflected organisational and systemic factors.
Conclusions
Online employee reviews posted by hospital workers on job sites provide valuable insights into healthcare organisational culture. Therefore, employee online reviews could be used as a supplementary, free source of data to inform organisational employee engagement initiatives.
Amelioration of Leigh syndrome induced by mouse blastocyst complementation with a mutant human mitochondrial ATP synthase 6
Authors: Yuan Huijun , Webster Keith , Bhatti Tariq , Hauswirth William , Lewin Alfred , Guy John 
Published: October 2021

Abstract
Mutations in mitochondrial genes are primary causes of multiple inherited disorders, especially affecting tissues with high aerobic energy demands such as the eye, brain, heart, and skeletal muscles. Such mitochondrial diseases are untreatable, have poor prognoses, and relevant animal models are few. Here we microinjected into the mouse blastocyst an adeno-associated virus (AAV) that we redirected to mitochondria to deliver the mutant human adenosine triphosphate (ATP) synthase subunit 6 gene (m.8993T>G) responsible for Maternally Inherited Leigh Syndrome, a neurologic disease renowned for causing rapidly fatal encephalomyelopathy in childhood or Neuropathy, Ataxia and Retinitis Pigmentosa in adults. Mice bred over six generations exhibited hallmarks of the human disease with one or multiple systemic symptoms including early death, paralysis, hunching, vision loss and seizures. Necropsy revealed spongiform encephalopathy, retinal degeneration, and cardiomegaly. Intravenous injection of a mitochondrially directed AAV serotype 9 vector containing wild-type ATP6 after disease onset, conferred prolonged survival and reduced paralysis. When administered prior to disease onset, all treated mice survived, and visual and motor function improved. These results support further development of gene therapy strategies involving intravenous delivery of mito-targeted AAV9.
Comparative Efficacy and Acceptability of Non-pharmacological Interventions for Depression Among People Living With HIV: Protocol for a Systematic Review and Network-meta Analysis
Authors: Zhao Ting , Tang Chulei , Yan Huang , Wang Honghong 
Published: October 2021

Abstract
Background: Improving depression is critical to successful HIV treatment. Due to the adverse reactions of pharmacotherapy, treatment for depression in PLWH has increasingly turned to non-pharmacological treatments. However, the comparative efficacy and acceptability of non-pharmacological treatments for depression among PLWH in different resource contexts remain inconclusive. This protocol for a systematic review and network meta-analysis aims at evaluating the efficacy and acceptability of non-pharmacological treatments for depression among PLWH to guide future research and practice for all research settings and for low-income and middle-income countries (LMIC) only. Methods: We will include all randomized controlled trials of any non-pharmacological interventions to reduce depression in PLWH. The primary outcomes will be the efficacy (the overall mean change scores in depression) and acceptability (the proportion of participants who withdrew for any reason). We will systematically search Published studies through the related databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, and CINAHL) and the bibliographies. There is no restriction by language and publication year. At least two investigators will independently conduct all study selection, quality evaluation, and data extraction. We will employ a network meta-analysis to synthesize all available evidence for each outcome and obtain a comprehensive ranking of all interventions for the global network and for low-income and middle-income countries (LMICs) network only. We will employ validated local and global approaches to assess inconsistency. We will use OpenBUGS (version 3.2.3) to fit our model into the Bayesian framework. We will evaluate the strength of evidence with the GRADE system. Discussion: We will synthesize all available evidence and identify the most efficacious and acceptable non-pharmacological interventions for depression among PLWH for global network and for LMIC network only. The results of this study will be used to guide decision-making better in different resource settings.Systematic review registration: PROSPERO CRD42021244230.
A Lateral Opening Injection Tool Used In Percutaneous Vertebroplasty To Treat Asymptomatic Osteoporotic Vertebral Burst Fractures: A Retrospective Study In 66 Cases
Authors: Sun Xin , Wang Jia , Liu Xingzhen , Tao Hairong , Zhu Tong , Wang Xiang , Shen Kangping , Jin Wenjie 
Published: October 2021

Abstract
Background: This study aimed to assess the results of percutaneous vertebroplasty (PVP) with a lateral opening injection tool for treating asymptomatic osteoporotic vertebral burst fractures (OVBFs) patients.Methods: 66 patients diagnosed with acute asymptomatic OVBFs with a spinal canal occupational ratio under 20% were treated with bilateral PVP using a lateral opening injection tool in our study. The related clinical outcomes and images were assessed, including Visual Analogue Scale (VAS), vertebral height (VH) ratio (=fractured VH/ adjacent nonfractured VH), the bone union of the fractured vertebral posterior wall, bone cement distribution, and complications.Results: The VAS scores were 3.80±0.40 at postoperative one day and 0.59±0.41 at last follow-up, significantly lower than 8.37±0.49 at pre-operation (P<0.05). The vertical distribution of bone cement in 60 cases contacted the upper and lower endplates of fractured vertebras. There was no leakage of bone cement in the spinal canal or displacement of posterior wall fracture to the spinal canal in all cases. There was asymptomatic cement leakage in 7 cases. The mean anterior, middle and posterior vertebral height ratios were significantly increased after PVP compared with preoperative values in all patients (P<0.05). At 6 months follow-up, there was no significant height loss of the vertebral body. Three months postoperatively, the posterior wall of fractured vertebral bodies was healed in all cases according to CT images. Conclusions: PVP using a lateral opening injection tool was effective and safe for treating asymptomatic OVBF patients.
Impact of Neonatal Frenotomy on the Breastfeeding Rate at Discharge from the Maternity Ward: A Prospective, Cohort Study
Authors: Maya-Enero Silvia , Ruiz-Guzmán Luis , Candel-Pau Júlia , Duran-Jordà Xavier , López-Vílchez María Ángeles 
Published: October 2021

Abstract
Background

Ankyloglossia may lead to an early abandonment of breastfeeding. Performing a frenotomy could increase the breastfeeding rate at discharge from the maternity ward.
Methods

This prospective cohort study included all the neonates born in our center in 2018 (1392). We offered a frenotomy to all tongue-tied patients. We determined how many frenotomies we performed (422), whether breastfeeding improved in the short term, and compared the breastfeeding rates between treated and untreated tongue-tied and non-tongue-tied neonates. Quantitative variables were described using the mean and standard deviation, and compared using a Student’s t-test. Rates of breastfeeding were compared using the Pearson chi square. Significance was set at the p < 0.05 level.
Results

The breastfeeding rate at discharge was higher among tongue-tied infants (92.1%) than non-tongue-tied (84.2%), and higher among treated than untreated neonates (93.1 vs 75.9%, respectively).
Conclusions

Frenotomy could help increase the breastfeeding rate at discharge among tongue-tied neonates.
Trial registration:
Not applicable
Pitfalls of DSGE Model Approach in Monetary Union
Authors: Konôpková Zlatica 
Published: October 2021

Abstract
This paper investigates the impact of country size on the DSEG model estimation of the monetary union. Following DSGE model for fiscal policy simulations (FiMod) the union is considered to have a two-country structure, the investigated country has weight in union equal to its population share and the second country represents the rest of members. The model is estimated for different country sizes and it is found there are two areas of equilibrium instability which covers 11 of 19 European Monetary Union members. The result is in contrary with Stähler and Thomas (2012) who estimated FiMod for Spain and stated that model can be recalibrated to every member of the monetary union. According to the result the size of country matters and affects the stability of equilibrium. Therefore, special attention is paid to small economies in monetary union. The results and consequences are then discussed with examples from recent history.
Evidence Based Practice Integration into Polygraph Practice: A suggested paradigm
Authors: Amsel Tuvya T. , Ginton Avital 
Published: October 2021

Abstract
The philosophy of evidence-based practice advocates professionals to rely on scientific evidence. Although the idea seems obvious, misuse of the philosophy raised controversy, which created confusion and misunderstanding of the concept. Yet, since it was introduced in the nineties to the medical community and despite the controversy, it gained more and more disciples and was embraced by nonmedical practitioners, including the polygraph profession. In the last decades, the polygraph community has gradually abandoned the intuitive-based polygraph practice that relies on less scientifically rooted subjective procedures and advanced toward evidence-based polygraph practice. This paper describes the evidence-based practice in general and details the practical aspects of evidence-based polygraph practice in particular, along with discussing the limitations of the current scientific research. It questions the current bone-tone trend to implement an extreme Evidence-Based approach into the polygraph practice, suggesting the practitioner to avoid a rigid “one size fit all” standardized protocols which are advocated as a must on the way to earn scientific recognition, whereas, in fact, it is the unfortunate outcome of lack of differential research data. As in the medical field, in-where the Evidence-Based practice managed to incorporate the clinical experience of experts with the hard research evidence and has not disregarded their valuable knowledge and experience, the present article calls for adopting this integrative approach in the polygraph field too and adjust the protocols to the specific circumstances of the case and the examinee in a “tailor-made” mode, which is based on existing data and flexible thinking wherever there is no data to rely on, as was suggested under the concept of “Adaptive-Polygraphy” (Ginton, 2013).
Directed Lie – The Correct or the Easy Way?
Authors: Shurany Tuvia , Gordon Nathan J. 
Published: October 2021

Abstract
Lately there had been a huge push in our profession toward the use to use the Directed Lie Comparison question (DLC). The truth verification field is divided into “pro and con” towards this idea, like many things in life. This article will research whether this “new fashion” is really the correct way or the easy or lazy way to conduct psychophysiological truth verification examinations, as well as make comparisons between the advantages and disadvantages between the DLC and the Probable Lie Comparison question (PLC).