bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burst properties of the highly active FRB20201124A using uGMRT
Authors: Marthi V R , Bethapudi S , Main R A , Lin H-H , Spitler L G , Wharton R S , Li D Z , Gautam T , Pen U-L , Hilmarsson G H 
Published: October 2021

Abstract
We report the observations of the highly active FRB20201124A with the upgraded Giant Metrewave Radio Telescope at 550-750 MHz. These observations in the incoherent array mode simultaneously provided an arcsecond localization of bursts from FRB20201124A, the discovery of persistent radio emission associated with the host galaxy, and the detection of 48 bursts. Using the brightest burst in the sample (F = 108 Jy ms) we find a structure-maximizing dispersion measure of 410.8 ± 0.5 pc cm−3. We find that our observations are complete down to a fluence level of 10 Jy ms, above which the cumulative burst rate scales as a power-law R( &gt; F) = 10 hr−1(F/10 Jy ms)γ with γ = −1.2 ± 0.2. We find that the bursts are on average wider than those reported for other repeating FRBs. We find that the waiting time between bursts is well approximated by an exponential distribution with a mean of ∼2.9 min during our observations. We searched for periodicities using both a standard Fourier domain method and the Fast Folding Algorithm, but found no significant candidates. We measure bulk spectro-temporal drift rates between −0.75 and −20 MHz ms−1. Finally, we use the brightest burst to set an upper limit to the scattering time of 11.1 ms at 550 MHz. The localization of FRB20201124A adds strength to the proof-of-concept method described in our earlier work and serves as a potential model for future localizations and follow-up of repeating FRBs with the uGMRT.
The IntAct database: efficient access to fine-grained molecular interaction data
Authors: del Toro Noemi , Shrivastava Anjali , Ragueneau Eliot , Meldal Birgit , Combe Colin , Barrera Elisabet , Perfetto Livia , How Karyn , Ratan Prashansa , Shirodkar Gautam , Lu Odilia , Mészáros Bálint , Watkins Xavier , Pundir Sangya , Licata Luana , Iannuccelli Marta , Pellegrini Matteo , Martin Maria Jesus , Panni Simona , Duesbury Margaret , Vallet Sylvain D , Rappsilber Juri , Ricard-Blum Sylvie , Cesareni Gianni , Salwinski Lukasz , Orchard Sandra , Porras Pablo , Panneerselvam Kalpana , Hermjakob Henning 
Published: October 2021

AbstractThe IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the International Molecular Exchange consortium, for which the IntAct database provides a shared curation and dissemination platform. The IMEx curation policy has always emphasised a fine-grained data and curation model, aiming to capture the relevant experimental detail essential for the interpretation of the provided molecular interaction data. Here, we present recent curation focus and progress, as well as a completely redeveloped website which presents IntAct data in a much more user-friendly and detailed way.
lncRNAfunc: a knowledgebase of lncRNA function in human cancer
Authors: Yang Mengyuan , Lu Huifen , Liu Jiajia , Wu Sijia , Kim Pora , Zhou Xiaobo 
Published: October 2021

AbstractThe long non-coding RNAs associating with other molecules can coordinate several physiological processes and their dysfunction can impact diverse human diseases. To date, systematic and intensive annotations on diverse interaction regulations of lncRNAs in human cancer were not available. Here, we built lncRNAfunc, a knowledgebase of lncRNA function in human cancer at https://ccsm.uth.edu/lncRNAfunc, aiming to provide a resource and reference for providing therapeutically targetable lncRNAs and intensive interaction regulations. To do this, we collected 15 900 lncRNAs across 33 cancer types from TCGA. For individual lncRNAs, we performed multiple interaction analyses of different biomolecules including DNA, RNA, and protein levels. Our intensive studies of lncRNAs provide diverse potential mechanisms of lncRNAs that regulate gene expression through binding enhancers and 3′-UTRs of genes, competing for miRNA binding sites with mRNAs, recruiting the transcription factors to gene promoters. Furthermore, we investigated lncRNAs that potentially affect the alternative splicing events through interacting with RNA binding Proteins. We also performed multiple functional annotations including cancer stage-associated lncRNAs, RNA A-to-I editing event-associated lncRNAs, and lncRNA expression quantitative trait loci. lncRNAfunc is a unique resource for cancer research communities to help better understand potential lncRNA regulations and therapeutic lncRNA targets.
Enhancing biological signals and detection rates in single-cell RNA-seq experiments with cDNA library equalization
Authors: Bacher Rhonda , Chu Li-Fang , Argus Cara , Bolin Jennifer M , Knight Parker , Thomson James A , Stewart Ron , Kendziorski Christina 
Published: October 2021

AbstractConsiderable effort has been devoted to refining experimental protocols to reduce levels of technical variability and artifacts in single-cell RNA-sequencing data (scRNA-seq). We here present evidence that equalizing the concentration of cDNA libraries prior to pooling, a step not consistently performed in single-cell experiments, improves gene detection rates, enhances biological signals, and reduces technical artifacts in scRNA-seq data. To evaluate the effect of equalization on various protocols, we developed Scaffold, a simulation framework that models each step of an scRNA-seq experiment. Numerical experiments demonstrate that equalization reduces variation in sequencing depth and gene-specific expression variability. We then performed a set of experiments in vitro with and without the equalization step and found that equalization increases the number of genes that are detected in every cell by 17–31%, improves discovery of biologically relevant genes, and reduces nuisance signals associated with cell cycle. Further support is provided in an analysis of publicly available data.
eQuilibrator 3.0: a database solution for thermodynamic constant estimation
Authors: Beber Moritz E , Gollub Mattia G , Mozaffari Dana , Shebek Kevin M , Flamholz Avi I , Milo Ron , Noor Elad 
Published: October 2021

AbstracteQuilibrator (equilibrator.weizmann.ac.il) is a database of biochemical equilibrium constants and Gibbs free energies, originally designed as a web-based interface. While the website now counts around 1,000 distinct monthly users, its design could not accommodate larger compound databases and it lacked a scalable Application Programming Interface (API) for integration into other tools developed by the systems biology community. Here, we report on the recent updates to the database as well as the addition of a new Python-based interface to eQuilibrator that adds many new features such as a 100-fold larger compound database, the ability to add novel compounds, improvements in speed and memory use, and correction for Mg2+ ion concentrations. Moreover, the new interface can compute the covariance matrix of the uncertainty between estimates, for which we show the advantages and describe the application in metabolic modelling. We foresee that these improvements will make thermodynamic modelling more accessible and facilitate the integration of eQuilibrator into other software platforms.
Nursing Care of 26 Infants Born to Mothers With COVID-19
Authors: Ding Lingli , Xiong Xiaoju , Yu Genzhen , Li Changyan , Wang Hui , Yang Yiran , Wu Shanshan , Cai Xianglian 
Published: October 2021

Background:
Novel coronavirus disease (COVID-19) has spread throughout the world; yet, there are few reports of neonatal cases. Thus, information about related clinical care experience is scarce.

Clinical Findings:
This case report includes 26 infants admitted to the neonatal intensive care unit (NICU) of Tongji Hospital in Wuhan City who were born to mothers with suspected/confirmed COVID-19. The nursing and medical staff implemented care of these infants in strict accordance with infection control measures.

Intervention:
Emergency measures for the prevention and control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the NICU were developed, and neonatal isolation, observation, and treatment were performed.

Outcomes:
Vital signs of the 26 infants remained stable during isolation and treatment, and no complications occurred. During the study period, neither the infants nor the nursing and medical staff were infected with SARS-CoV-2.

Practice Recommendations:
Based on our strict practices, infants born to mothers with suspected/confirmed COVID-19 should receive care in a single-patient room to support infection control and provide enhanced observation. During initial contact and nursing care, increased attention should be given to the protection of infants born to mothers with suspected/confirmed COVID-19.
Laryngoscopic Screening Before Revision Anterior Cervical Spine Surgery
Authors: Seok Sang Yun , Lee Dong-Ho , Park Se Han , Lee Hyung Rae , Cho Jae Hwan , Hwang Chang Ju , Lee Choon Sung 
Published: October 2021

Study Design:
Retrospective study.

Objectives:
The aim was to evaluate the exact incidence of vocal cord palsy (VCP) caused by previous anterior cervical spine surgery (ACSS) and aid surgeons in deciding the approach direction in revision ACSS.

Summary of Background Data:
The incidence of VCP detected by preoperative laryngoscopic screening before revision ACSS appeared to be much higher in previous reports than in our experience.

Materials and Methods:
We reviewed the data of 64 patients who underwent revision ACSS. Preoperative laryngoscopy was performed in all patients to detect VCP and/or structural abnormalities of the vocal cords. The patients’ characteristics, laryngoscopy results, and symptoms before revision surgery that were potentially caused by previous recurrent laryngeal nerve injuries (voice change, foreign body sensation, and chronic aspiration) were recorded.

Results:
Laryngoscopy demonstrated no complete VCP or decreased vocal cord motility. Eleven patients (17.2%) showed vocal cord-related symptoms and 13 patients (20.3%) showed abnormal laryngoscopic findings without VCP. Four patients (6.2%) showed vocal cord-related symptoms and abnormal laryngoscopic findings simultaneously. At the initial operative level, no significant differences in vocal cord-related symptoms were observed between the upper and lower levels (C3-4-5 vs. C5-6-7). However, the frequency of vocal cord-related symptoms was significantly high at the larger number of levels (≥3 segments) (P=0.010).

Conclusions:
In contrast to previous reports, this study demonstrated that VCP is rarely detected before revision ACSS. Therefore, deciding the approach direction with only vocal cord motility can be dangerous, and more attention is required in setting the approach direction in patients who show both vocal cord-related symptoms and abnormal laryngoscopic finding. In other cases, a contralateral approach which has a low risk of bilateral VCP could be utilized if necessary.
Effects of dipeptidyl peptidase-4 inhibition on portal hypertensive and cirrhotic rats
Authors: Huang Hui-Chun , Hsu Shao-Jung , Chuang Chiao-Lin , Hsiung Shao-Yu , Chang Ching-Chih , Hou Ming-Chih , Lee Fa-Yauh 
Published: October 2021

Background:
Portal hypertension is a pathophysiological abnormality with distinct vascular derangements associated with liver cirrhosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetic agents which exert pleiotropic vascular effects, but their relevant impact on portal hypertension and liver cirrhosis remains unclear. This study aims to clarify this issue.

Methods:
Rats receiving partial portal vein ligation (PVL) and common bile duct ligation (BDL) served as experimental models for portal hypertension and cirrhosis, respectively. After linagliptin (a DPP-4 inhibitor) treatment, the survival rate, hemodynamics, biochemistry parameters and liver histopathology were evaluated. In addition, the collateral vascular responsiveness and severity of portal-systemic shunting were examined. mRNA and protein expression in the vasculature and liver were also examined.

Results:
Linagliptin significantly reduced portal pressure (control vs linagliptin: 12.9 ± 1.2 vs 9.1 ± 2.0 mmHg, p = 0.001) and upregulated nitric oxide synthase expression in the collateral vessel, superior mesentery artery, and liver of PVL rats. However, the portal hypotensive effect was insignificant in BDL rats. Glucose plasma levels, liver and renal biochemistry parameters were not significantly altered by linagliptin. The degree of portal-systemic shunting and collateral vascular responsiveness were also not significantly altered by linagliptin treatment. Linagliptin did not improve liver fibrosis and hepatic inflammation in BDL rats.

Conclusion:
DPP-4 inhibition by linagliptin reduced portal pressure in portal hypertensive rats but not in cirrhotic rats. It may act by decreasing intrahepatic resistance via upregulation of hepatic nitric oxide synthase in portal hypertensive rats.
Implantation of monocusp valve prolongs the duration of chest tube drainage in children with tetralogy of fallot after corrective surgery
Authors: Huang Shao-Wei , Hsu Wan-Fu , Li Hsing-Yuan , Hwang Betau , Wu Fei-Yi , Weng Zen-Chung , Chuang Chieh-Mao , Chen Shyi-Jou , Wang Chih-Chien , Wang Der-Shiun , Lee Pi-Chang 
Published: October 2021

Background:
Right ventricular outflow tract obstruction relief is one of the major procedures during the total correction of tetralogy of Fallot (TOF). Pulmonary insufficiency (PI) is usually inevitable after a transannular incision with a patch repair is performed. Therefore, some surgeons advocate to place a monocusp valve within the transannular patch (TAP) in order to decrease the severity of the PI. However, the monocusp valve seemed not be very effective in some patients who underwent the complete TOF repair.

Methods:
Patients who had the classic form of TOF between January 2009 and January 2017 and underwent the corrective surgery with a TAP by the same cardiovascular surgeon were identified for further analysis. Clinical information including demographics at operation, perioperative data, and postoperative outcome were collected retrospectively and compared between the group with and without a monocusp valve.

Results:
A total of 24 TOF cases were included in the final analysis, and 16 (66.7%) patients received a monocusp valve placement. The patients’ characteristics before and during the surgery were similar between the two groups. The median duration of chest tube drainage after the total correction in the monocusp group was longer than those without the valve (p = 0.04). There was no difference in the immediate postoperative data, including the inflammation/infection status, the duration of mechanical ventilation, and the length of ICU and hospital stay.

Conclusion:
Implantation of a monocusp valve during the total TOF correction using a TAP did not bring benefit to improve the immediate postoperative outcomes, especially the duration of the pleural drainage. Further study with a prospective design and a larger number of cases is needed.
New-Onset Solitary Black Lesion on the Heel
Authors: Ingrasci Giuseppe , Yosipovitch Gil 
Published: October 2021

ABSTRACT
The new onset of a darkly pigmented lesion of the heel is a common reason for patients to present to their dermatology clinic. Herein, we describe a photo quiz of a case of a darkly pigmented lesion that appeared on the heel of a middle-aged adult. The answer choices include the differentials for a new-onset darkly pigmented lesion on the heel, and the correct answer can only be elucidated given the patient history, appearance of the lesion, and findings upon dermoscopy and paring of the lesion. Accurate diagnosis and proper management are important to reduce significant morbidity and costs associated with unnecessary invasive procedures or treatments.
Functional and Aesthetic Lower Lip Reconstruction Using the Yotsuyanagy Flap
Authors: Alfonso Amanda , Parra Carreño Andrés , Beltrán Paloma P. 
Published: October 2021

Abstract
Lower lip defects are a major challenge from a reconstructive perspective. The lower lip is an anatomical region formed by different types of tissue, and it is essential to obtain adequate functional and aesthetic results. When local tissue is available to be a donor area, it becomes the best option to repair the defect. This article's purpose is to present our experience in reconstruction of partial or transfixing total defects of the lower lip with the musculocutaneous flap of the depressor anguli oris described by Yotsuyanagi.
The Application of Modified Kite Flap in Repairing Facial Skin Defects After Tumor Resection
Authors: Wu Yi , Peng Jianzhong , Luo Xianyan , Wang Tao 
Published: October 2021

Introduction
The kite flap is widely used in the repair of facial skin defects because of its high survival rate and simple operation. However, the flap mobility of traditional kite flap is limited and needs to be improved. We conducted this survey to evaluate clinical efficacy of modified kite flap in repairing facial skin defects after tumor resection.

Methods
Clinical data of 25 patients with facial skin tumors were collected and analyzed. All patients received skin defect repair with modified kite flaps after Mohs surgery. The survival conditions of the flaps were observed 24 hours after the surgery. The patients were followed up at the first month and the third month after surgery and then every 3 months thereafter. The shape and texture of the flaps, as well as the matching degree with surrounding tissues, were evaluated.

Results
All the flaps were survived without infection and healed by the first intervention. The shape and color of the flaps were all good without obvious scar. Satisfactory functional and cosmetic results were achieved in both donor sites and recipient sites.

Conclusions
The modified kite flap is effective for the repair of facial skin defects, which has a high survival rate and larger mobility.
Signatures of Brain Network Alteration in Psychogenic Non-Epileptic Seizures: A Rest-EEG Study Based on Power Spectral Density and Phase Lag Index
Authors: Varone Giuseppe , Boulila Wadii , Giudice Michele Lo , Benjdira Bilel , Mammone Nadia , Ieracitano Cosimo , Dashtipour Kia , Neri Sabrina , Gasparini Sara , Morabito Francesco Carlo , Hussain Amir , Aguglia Umberto 
Published: October 2021

AbstractThe main challenge in the clinical assessment of Psychogenic Non-Epileptic Seizures (PNES) is the lack of an electroencephalographic marker in the electroencephalography (EEG) readout. Although decades of EEG studies have focused on detecting cortical brain function underlying PNES, the principle of PNES remains poorly understood. To address this problem, electric potentials generated by large populations of neurons were collected during the resting state to be processed after that by Power Spectrum Density (PSD) for possible analysis of PNES signatures. Additionally, the integration of distributed information of regular and synchronized multi-scale communication within and across inter-regional brain areas has been observed using functional connectivity tools like Phase Lag Index (PLI) and graph-derived metrics. A cohort study of 20 PNES and 19 Healthy Control subjects (HC) were enrolled. The major finding is that PNES patients exhibited significant differences in alpha-power spectrum in brain regions related to cognitive operations, attention, working memory, and movement regulation. Noticeably, we observed that there exists an altered oscillatory activity and a widespread inter-regional phase desynchronization. This indicates changes in global efficiency, node betweenness, shortest path length, and small worldness in the delta, theta, alpha, and beta frequency bands. Finally, our findings look into new evidence of the intrinsic organization of functional brain networks that reflects a dysfunctional level of integration of local activity across brain regions, which can provide new insights into the pathophysiological mechanisms of PNES.
Client use of blockchain technology: exploring its (potential) impact on financial statement audits of Australian accounting firms
Authors: Dyball Maria Cadiz , Seethamraju Ravi 
Published: October 2021

PurposeThe paper reports on a study that investigated the (potential) impact of client use of blockchain technology on financial statement audits of Australian accounting firms.Design/methodology/approachData were primarily collected from semi-structured interviews with a range of stakeholders including audit partners from first- and second-tier accounting firms in Australia. The interviews focused on the perceived (potential) impact of blockchain on the stages of obtain (retain) engagement, engagement planning, risk assessment, audit evidence and reporting of financial statement audits of clients that use blockchain technology. Perceptions of changes to financial statement audits were interpreted using the logics of professionalism and commercialism.FindingsAustralian accounting firms have either obtained or considered engagements with clients with a cryptocurrency business or that use a blockchain platform although they are a small group. There is a view that blockchain technology is distinctive and therefore poses risks not encountered before in audit engagements. These risks would most likely shift how firms plan, design audit methodologies and execute financial statement audits. The study showed that the logics of professionalism and commercialism are not conflicting but instead complementary. They present both opportunities and challenges for firms to apply and develop audit expertise in an emerging area in audit.Research limitations/implicationsBeing an exploratory study, the findings are tentative. A case study of an audit engagement with a cryptocurrency business will add to a nuanced understanding of the challenges posed to financial statement audits by blockchain technology.Originality/valueThis study is novel because of its focus on the impact of an evolving technology on the stages of financial statement audits.