bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Therapeutic Potential of Targeting the Angiotensin Pathway as a Novel Therapeutic Approach to Ameliorating Post-surgical Adhesions
Authors: Khalili-Tanha Ghazaleh , Khalili-Tanha Nima , Nazari Seyedeh Elnaz , Chaeichi-Tehrani Negin , Khazaei Majid , Aliakbarian Mohsen , Hassanian Seyed Mahdi , Ghayour-Mobarhan Majid , Ferns Gordon A. , Avan Amir 
Published: June 2021

Background:
Post-surgical adhesion is a common complication after abdominal or pelvic surgeries.
Despite improvements in surgical techniques or the application of physical barriers, few improvements have
been achieved. It causes bowel obstruction, pelvic pain, and infertility in women and has an adverse effect on
the quality of life. Renin-Angiotensin System (RAS) is traditionally considered a blood pressure regulator.
However, recent studies have indicated that the RAS plays a vital role in other processes, including oxidative
stress, fibrosis, proliferation, inflammation, and wound healing. Angiotensin II (Ang II) is the main upstream effector
of the RAS that can bind to the AT1 receptor (ATIR). A growing body of evidence has revealed that targeting
Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II type 1 Receptor Blockers (ARBs),
and Direct Renin Inhibitors (DRIs) can prevent post-surgical adhesions. Here we provide an overview of the
therapeutic effect of RAS antagonists for adhesion.

Methods:
PubMed, EMBASE, and the Cochrane library were reviewed to identify potential agents targeting
the RAS system as a potential approach for post-surgical adhesion.

Results:
Available evidence suggests the involvement of the RAS signaling pathway in inflammation, proliferation,
and fibrosis pathways as well as in post-surgical adhesions. Several FDA-approved drugs are used for targeting
the RAS system, and some of them are being tested in different models to reduce fibrosis and improve
adhesion after surgery, including telmisartan, valsartan, and enalapril.

Conclusion:
Identification of the pathological causes of post-surgical adhesion and the potential role of targeting
the Renin-Angiotensin System may help to prevent this problem. Based on the pathological function of
RAS signaling after surgeries, the administration of ARBs may be considered a novel and efficient approach to
prevent postsurgical adhesions. Pre-clinical and clinical studies should be carried out to have better information
on the clinical significance of this therapy against post-surgical adhesion formation.
Power representation in the leadership of academic libraries in Indonesia
Authors: Laugu Nurdin 
Published: June 2021

Introduction. Libraries as a dynamic environment have supported dynamic interactions in various aspects of life. These interactions occur in several frames such as culture, social, and ideology that pose power in library leadership at universities.
Data Collection Method. In-depth interviews with nine informants, consisting of heads, librarians, and library staff in three libraries, conducted unstructurally between 2018 and 2020. Interview data was used as the main data collection technique, supported by observations and documentation.
Data Analysis. Miles and Huberman's model with three stages, i.e. data reduction, data presentation, and conclusion or verification, was employed to interpret findings.
Results and Discussion. The results showed five main issues, which are directly related to power representation in libraries. These issues include religious understanding, institutional vision, temporary power, seniority of library personnels, and the influence of the library collection development.
Conclusion. The representation of power in library leadership practices has emerged in the frames of religiosity, organizational ideology, seniority, power, and impact of library collection. Therefore, this research contributes to library science theorists and practitioners concerning the awareness of the power representation issues.
Persepsi pemustaka terhadap layanan perpustakaan “Rumah Ilmu” Universitas Negeri Semarang
Authors: Handoyo Mokhamad Zakaria Eko , Burhanudin Muhamad , Rahmadhani Amalia 
Published: June 2021

Introduction. Universitas Negeri Semarang (UNNES) Main Library is committed to providing excellent services. One of the activities is to understand the users’ needs. This paper investigates the users’ perceptions of UNNES Main Library services. The objectives of the study include; (1) determining users’ perception on library services quality, (2) Examining satisfaction level of library services, (3) Measuring users’satisfaction level based on Service Satisfaction Index.
Data Collection Methods. The paper used a quantitative methods approach with questionnaires, involving 203 library users, selected randomly.
Data Analysis. The data were descriptively analysed by using an online survey tool (SurveyGizmo.com).
Results and Discussion. The results report; (1) Users were satisfied with library services quality, but less satisfied with book collections; (2) Satisfaction level of library services was satisfactory; (3) Average score of customer satisfaction was 2.89, within the interval scale of 2.52 to 3.27.
Conclusions. Based on the findings concluded that user’s perceptions of UNNES library services were satisfied and furthermore, the UNNES library will continue to improve the quality of services until it achieves very satisfying results.
A COST VARIATION ANALYSIS STUDY OF DRUGS USED IN THE MANAGEMENT OF BENIGN PROSTATIC HYPERPLASIA AVAILABLE IN THE INDIAN MARKET
Authors: RANI VIBHA , VENEPALLY SAILAXMI 
Published: June 2021

Objectives: The objectives of the study are to evaluate the cost variation and cost ratio of different brands of the drugs used in the treatment of benign prostatic hyperplasia (BPH).
Methods: The cost of alpha-blockers and 5 alpha-reductase inhibitors used in the treatment of BPH was noted from CIMS (Oct 2019–Jan 2020), Drugs Update, and Medline. The differences between the maximum and minimum cost of various brands of the same drug were analyzed and percentage variation in the cost was calculated. The results of the study were expressed in absolute numbers and percentages.
Results: All the drugs used in the treatment of BPH are only available in tablet and capsule forms, in 10 different dosages and in 242 different brand names, of which 10 mg alfuzosin and 2.5 mg finasteride have the highest (518) and lowest (14) percentage of cost variation, while 0.4 mg tablet form of tamsulosin is available in the maximum number of brands-41.
Conclusion: This pharmacoeconomic study reveals that there is wide variation in the cost of most of the drugs used in the treatment of BPH. Therefore, it is very much essential for both government and pharmaceutical companies to make combined efforts to reduce the cost of these drugs, which will reduce the economic burden on the patients and also reduce the overall health care costs.
A COMPARATIVE STUDY OF CAUDAL BLOCK AND ULTRASOUND-GUIDED TRANSVERSUS ABDOMINIS PLANE BLOCK WITH LEVOBUPIVACAINE AND DEXAMETHASONE AS ADDITIVE IN EXTRAPERITONEAL LOWER ABDOMINAL SURGERIES IN PEDIATRICS
Authors: GHODKE SANDHYA , N MADHAVI , RN HIREMATH 
Published: June 2021

Objective: The objective of the study was to evaluate the efficacy of ultrasound-guided transversus abdominis plane (TAP) block versus caudal block for post-operative analgesia with levobupivacaine and dexamethasone as additive in extraperitoneal lower abdominal surgeries in pediatrics as there is no available literature showing the same.
Methods: This is a randomized control study carried out between two groups among 50 children (1–8 years of age), both sexes, posted for elective extraperitoneal lower abdominal surgeries after taking informed consent from parents. Fifty children were randomly allocated into two groups, 25 in each group. Caudal epidural (CE) group received general anesthesia and caudal block with 1 ml/kg of 0.2% levobupivacaine and 0.1 mg/kg dexamethasone. TAP group received general anesthesia and ultrasound-guided TAP block with 0.5 ml/kg of 0.2% levobupivacaine and 0.1 mg/kg dexamethasone. Data were collected by means of pre-designed format with pre-/post-operative assessment with standardized scores.
Results: The mean age of the patients was 4.84 (SD=2.29). Mean face, legs, activity, cry, and consolability score was low and non-significant before shifting the patient (<2 h post-operative [post-op]) in both the groups. Thereafter from 2 to 12 h, the mean score increased to 4.92 (SD=2.72) in the CE group and 2.92 (SD=2.17) in the TAP group and the difference was statistically significant at 2 h, 4 h, 6 h, and 12 h postoperatively. Mean time to rescue analgesia in the CE group was 4.96 h (SD=4.32) and 5.52 h (SD=7.53) in the TAP group and difference was statistically significant (p=0.000). Mean total rescue analgesic requirement for the CE and TAP groups was 298.40 mg (SD=170.70) and 111.40 mg (SD=138.81) and the difference was also significant. Post-operative complications such as urinary retention and motor blockade were seen in 28% of CE patients, while none of the patients experienced post-operative nausea/vomiting.
Conclusions: Our study showed significant increase in duration of post-operative analgesia among TAP patients with reduced requirement of rescue analgesics and lesser post-operative complications as compared to CE patients
COMPARATIVE STUDY OF HISTOLOGICAL AND HISTOCHEMICAL PROPERTIES OF PERITONEAL MAST CELLS OF ALBINO RAT USING TWO TYPES OF FIXATIVES
Authors: NIRALA KAMTA PRASAD , GUPTA SUBHASH 
Published: June 2021

Objectives: To make a comparative study of histological and histochemical properties of peritoneal mast cells in albino rat using neutral buffered formalin and formal alcohol as fixatives.
Methods: The stretch preparation from Albino rat peritoneum was made on chemically clean glass slides and immediately placed into the fixatives.
Results: With toluidine blue (pH 4.4), the mast cells stained deep purple and similar reaction was obtained with toluidine blue at pH 2. These staining reactions indicate the presence of substantial amount of heparin trisulfate, small amount of heparin monosulfate, and neutral mucopolysaccharide.
Conclusion: Heparin trisulfate is an active form of heparin and is the main constituent of the mast cell granules of the albino rat.
ANÁLISE DE SAZONALIDADE NA SÉRIE DOS PREÇOS MÉDIOS DA BANANA E TOMATE CONSTANTES NA CESTA BÁSICA DO MUNICÍPIO DE VITÓRIA DA CONQUISTA, BA
Authors: De Carvalho Delza Rodrigues , Santos Josefa de Lisboa , Amaral Marcelo Santos , Santana Júnior Gildásio 
Published: June 2021

Este artigo tem por objetivo estudar o comportamento sazonal da série dos preços médios do tomate e da banana da prata, bem como os seus impactos nos gastos da Cesta básica do Município de Vitória da Conquista, utilizando a Análise de Séries Temporais, por meio dos modelos clássico aditivo e multiplicativo, em planilha eletrônica de Excel. Os dados foram fornecidos pelo Programa de Indicadores Econômicos da UESB e compreendem os preços médios mensais coletados entre outubro de 2014 e julho de 2019. Nos resultados apresentados pelos modelos, houve influência da sazonalidade, apresentando quedas nos preços médios para os meses de setembro, outubro, novembro e dezembro, e aumentos nos preços para os meses de fevereiro, marco, abril e maio. A variação dos preços médios de alguns dos produtos que compõem a cesta básica é influenciada pela mudança climática que determina as melhores épocas para plantio e colheita no Brasil. Conclui-se, destacando a importância de se fazer uma análise sazonal, não só para a série de produtos que impactam no custo da cesta básica, como para todas as outras séries econômicas semelhantes.
Relationship Quality in Geriatric Healthcare Delivery: A sustainable model
Authors: Joseph Sindhu 
Published: June 2021

Objective: This study is undertaken to examine geriatric relationship quality in healthcare delivery in Kerala. Drawing the hypothetical relationship, a model for elderly geriatric healthcare delivery to be developed.
Methods: A Structural Equation Modelling technique, based on a positivist approach, was employed to analyse the association between relationship quality and geriatric healthcare delivery. The data was collected from 405 elderly people in Kerala between June 2020 and November 2020.
Results: A consistent empirical model of predictive relationships between the hypothesized variables was found, and a geriatric relationship quality healthcare model was developed. Service quality has emerged as a significant determinant of relationship quality. Even though patient centricity is not hypothetically related to relationship quality, it is a significant determinant of service quality.
Conclusion: Geriatric healthcare management must consider relationship quality as a prominent factor while evaluating the quality of healthcare delivery as it is the outcome of all the structural and procedural aspects.
PENENTU KEUNGGULAN BERSAING PADA UMKM : APAKAH KOMPETENSI DIGITAL DAN ORIENTASI KEWIRAUSAHAAN PENTING ?
Authors: Sari Sofi Maya , Yunizar Yunizar , Sartika Dina 
Published: June 2021

One of the efforts to improve the competitive advantage in rapid technological developments, especially in Micro, Small and Medium Enterprises (MSMEs), is to maximize the potential of human resources. However, at this time human resources MSMEs’owners are not acceptable in digital competence and low ability to improve entrepreneurial orientation. The role of human resources consisting of digital competence and entrepreneurial orientation leads to the competitive advantages of micro, small and medium enterprises. The study used a quantitative approach, using multiple regression analyses to analyze a questionnaire sample of 180 micros, small, and medium enterprises manufacture of food products in Bandung City. Results showed digital competence and entrepreneurial orientation have positive effect on competitive advantage. Salah satu usaha untuk dapat meningkatkan keunggulan bersaing ditengah perkembangan teknologi yang pesat khususnya pada Usaha Mikro, Kecil, dan Menengah (UMKM) adalah dengan memaksimalkan potensi dari sumber daya manusia yang dimilikinya. Namun begitu saat ini sumber daya manusia atau pelaku usaha mikro, kecil dan menengah kurang akseptabel dalam penguasaan kompetensi digital serta rendahnya kemampuan dalam meningkatkan sikap orientasi kewirausahaannya. Peranan sumber daya manusia yang terdiri dari kompetensi digital dan orientasi kewirausahaan ini mengarah kepada keunggulan bersaing usaha mikro, kecil, dan menengah. Penelitian ini menggunakan pendekatan kuantitatif, dengan menggunakan analisis regresi berganda untuk menganalisis sampel kuisioner sebanyak 180 pelaku UMKM industri pengolahan makanan di Kota Bandung. Hasil penelitian mengungkapkan bahwa kompetensi digital dan orientasi kewirausahaan berpengaruh positif terhadap keunggulan bersaing.
ANALISIS RETURN SAHAM DENGAN PENDEKATAN MONDAY EFFECT DAN WEEKEND EFFECT DI BURSA EFEK INDONESIA
Authors: Alexandri Mohammad Benny , Dai Ratna Meisa , Fauziyah Ema 
Published: June 2021

This study discusses the analysis of stock returns using the Monday effect and Weekend effect on the Indonesia Stock Exchange in the LQ45 period February 2017 - January 2018. The method of analysis technique used is the partial test with SPSS software ver.21 . The results of this study indicate that there is an effect of the Monday effect and Weekend effect on the LQ45 daily stock return on the Indonesia Stock Exchange, where the lowest return occurs on Monday (Monday effect) and the highest return on Friday (weekend effect), in addition there is the lowest return concentrated in the last two weeks of each month (fourth and fifth week) or also called week four effect. Penelitian ini membahas tentang analisis return saham dengan menggunakan pendekatan Monday effect dan Weekend effect di Bursa Efek Indonesia pada LQ45 periode Februari 2017 - Januari 2018. Teknik analisis data yang digunakan menggunakan uji parsial dengan software SPSS ver.21. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh Monday effect dan Weekend effect terhadap return saham harian LQ45 di Bursa Efek Inonesia, di mana return terendah terjadi pada hari Senin (Monday effect) dan return tertinggi pada hari Jumat (weekend effect), selain itu terdapat return yang terendah terkonsentrasi pada dua minggu terakhir setiap bulannya (minggu keempat dan kelima) atau disebut juga week four effect.
ANALISIS PENGUNAAN WHATSAPP BUSINESS UNTUK MENINGKATKAN PERJUALAN DAN KEDEKATAN DENGAN PELANGGAN DI PT SAUNG ANGKLUNG UDJO
Authors: Hendriyani Chandra , Dwianti Selvia Putri , Herawaty Tetty , Ruslan Budiana 
Published: June 2021

The use of communication platforms is beneficial for companies, one of which is the use of mobile-based applications, namely the WhatsApp Business application, to meet market demands that require easy access to information directly and quickly. The purpose of this study was to determine the increase in sales at PT Saung Angklung Ujdo after using WhatsApp Business in the implementation of the sales process. The research method used is a qualitative method with a descriptive approach. Data collection techniques are carried out by observation, interviews with the Digital Strategy Manager, and literature study of books, journals, and documents related to research discussions. The results show that there is a match between theory and practice in the sales process with the use of the WhatsApp Business application and an increase in sales after the use of the WhatsApp Business application by PT Saung Angklung Udjo. Penggunaan platform komunikasi sangat membantu perusahaan salah satunya adalah penggunaan aplikasi berbasis mobile yaitu aplikasi WhatsApp Business untuk memenuhi tuntutan pasar yang membutuhkan kemudahan akses informasi secara langsung dan cepat. Tujuan dari penelitian ini adalah untuk mengetahui peningkatan penjualan pada PT Saung Angklung Ujdo setelah menggunakan WhatsApp Business dalam pelaksanaan proses penjualannya. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data dilakukan dengan observasi, wawancara dengan Manajer Strategi Digital, dan studi pustaka terhadap buku, jurnal, dan dokumen yang berkaitan dengan pembahasan penelitian. Hasil penelitian menunjukkan bahwa terdapat kesesuaian antara teori dan praktek dalam proses penjualan dengan penggunaan aplikasi WhatsApp Business dan peningkatan penjualan setelah penggunaan aplikasi WhatsApp Business yang dilakukan oleh PT Saung Angklung Udjo.
WORK ENGAGEMENT KARYAWAN GENERASI MILENIAL PADA PT. X BANDUNG
Authors: Sukoco Iwan , Fu’adah Dian Nur , Muttaqin Zaenal 
Published: June 2021

This article aims to determine the description and level of work engagement of millennial generation employees at PT X. The method used is a quantitative method with a descriptive approach. The study population was all employees of the millennial generation of PT. X total 132 employees. The sampling technique used the Slovin formula with a total of 57 people. Collecting data in the form of a work engagement questionnaire with dimensions of vigor, dedication and absorption, interviews, and observation. The results obtained in this study are employees of the millennial generation of PT. X majority has high level of work engagement, meaning that most employees experience a positive state of mind regarding their work. This is shown when the millennial generation employees of PT. X able to stay focused and concentrated on work even though the work is tough, feels that what he is doing is a noble job, and enjoys a very intense job (full of concentration). Artikel ini bertujuan untuk mengetahui gambaran dan tingkat work engagement karyawan generasi milenial di PT X. Metode yang digunakan adalah metode kuantitatif dengan pendekatan deskriptif. Populasi penelitian adalah seluruh karyawan generasi milenial PT. X yang berjumlah 132 karyawan. Teknik pengambilan sampel menggunakan rumus slovin dengan jumlah 57 orang. Pengumpulan data berupa kuesioner work engagement dengan dimensi vigor, dedication dan absorption, wawancara, dan observasi. Hasil yang diperoleh dalam penelitian ini adalah karyawan generasi milenial PT. X mayoritas memiliki work engagement pada tingkat tinggi, artinya sebagian besar karyawan mengalami keadaan pikiran positif terkait pekerjaannya. Hal ini ditunjukkan ketika bekerja karyawan generasi milenial PT. X mampu tetap fokus dan konsentrasi terhadap pekerjaan walaupun pekerjaan tersebut berat, merasa apa yang dikerjakan merupakan pekerjaan mulia, dan menikmati pekerjaan yang sangat intens (penuh konsentrasi).
PENGEMBANGAN BISNIS PADA STARTUP TEMANRINDU DENGAN METODE STARTUP EVOLUTION CURVE
Authors: Yudhistira Rasyid , Yuniaristanto Yuniaristanto , Hisjam Muhammad 
Published: June 2021

Technological developments have made it easier for people to use social networks. Almost all people of productive age use the internet in their social interactions. The purpose of this research is primarily to provide a platform for TemanRindu to make its product prototype appropriately with the Lean Canvas business model and so Startup Evolution Curve as its method. The main principles of Startup Evolution Curve are providing step-by-step guidance in company discussions, business development of TemanRindu by Feasibility Study especially on market aspect so that shown the segment and position TemanRindu itself. Product prototyping or Minimum Viable Product (MVP) start from doing hypothesis verification that will be used on MVP adjustment. Slogan making and pipe and sales funnel are also be done that lately will be used to planning the marketing strategy. This method has succeeded on generating of TemanRindu’s market segmentation and positioning as well as the making of product prototype in the form of Instagram design based on Lean Canvas design. Its affect on increasing of business growth in followers, likes, comments and saves because the product has been more adapted to customer needs without reducing the added value that offered.Perkembangan teknologi menyebabkan semakin mudahnya masyarakat dalam menggunakan jejaring sosial. Hampir keseluruhan masyarakat usia produktif memakai internet dalam interaksi sosialnya. Tujuan dari penelitian ini adalah menyediakan sarana untuk startup TemanRindu dalam membuat prototipe produk bisnisnya dengan model bisnis Lean Canvas secara tepat dan dengan metode Startup Evolution Curve. Prinsip utama dari Startup Evolution Curve adalah memberikan arahan per tahap dalam diskusi perusahaan, dan pengembangan bisnis startup TemanRindu melalui Feasibility Study pada aspek pasar sehingga memberikan gambaran terhadap segmen dan posisi daripada TemanRindu. Pembuatan prototipe produk atau Minimum Viable Product (MVP) dilakukan dari verifikasi hipotesis yang akan digunakan pada penyesuaian MVP. Pembuatan slogan hingga uji komunikasi dan saluran distribusi juga dilakukan yang kemudian dapat digunakan untuk menentukan strategi pemasaran. Pengaplikasian metode tersebut berhasil menghasilkan pemetaan daripada segmentasi dan posisi TemanRindu di pasar dan juga terciptanya prototipe produk TemanRindu berupa desain kiriman Instagram yang berdasarkan atas rancangan Lean Canvas. Dampaknya pertumbuhan bisnis naik, baik pada followers, likes, comment maupun save karena produk telah lebih disesuaikan dengan kebutuhan pelanggan tanpa mengurangi nilai lebih yang ditawarkan TemanRindu.