bluuebunny/crossref_metadata_2025_split huggingface dataset:
ÍNDICE DE MATERIAS Y AUTORES Volumen 6, números 1 al 4 del 2019
Authors: Endocrinología, Diabetes y Metabolismo Asociación Colombiana de 
Published: August 2021

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Editoriales
Diabetes, detección temprana para una enfermedad compleja Luz Ángela Casas Vol. 6, n.° 1, p. 4 La vitamina reina o la reina de las vitaminas Ardila E Vol. 6, n.° 2, p. 72 El trabajo en equipo y la ACE Tovar H Vol. 6, n.° 3, p. 152 Editorial Rojas W Vol. 6, n.° 4, p. 250 15° Congreso Colombiano de Endocrinología, Diabetes y Metabolismo Marta Elena Marín Grisales Vol. 6, supl. 1, p. 4
Orbitopatía tiroidea
Authors: Jácome Roca Alfredo 
Published: August 2021

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La enfermedad de Graves (EG) es una de las patologías más interesantes que competen al endocrinólogo. Siempre consideré que la orbitopatía (OG) era una rueda suelta en el manejo de la EG (además del más raro mixedema pretibial), y parecía que los oftalmólogos tampoco estaban muy familiarizados con ella. Algunos insistían en usar los epónimos de sus signos oculares, lo que nunca me pude aprender, y parece que ya se ha olvidado. Los signos oculares aparecen aproximadamente en 1 de cada 4 pacientes, y cuando esto ocurre (además de encaminar al médico hacia el diagnóstico), generalmente son de naturaleza leve. Las OG moderadas y severas afortunadamente son menos frecuentes; el artículo de Gómez y colaboradores (1) nos actualiza en tan difícil tema. La preferencia del endocrinólogo sobre el tratamiento de la EG ha variado a través del tiempo. La tiroidectomía fue la primera en desacreditarse porque, como se hacían subtotales, permitían la recurrencia del remanente tiroideo. Los antitiroideos, al principio muy de moda, empezaron a ser menos utilizados por el alto porcentaje de recurrencia. Algún autor recomendaba el uso concomitante de triyodotironina para disminuir los relapsos; sin embargo, el yodo radiactivo (I-131) empezó a posicionarse de primeras por su alta eficacia en la prevención de recurrencias, aunque había que manejar el hipotiroidismo de manera constante.
Conclusiones de la primera mesa de trabajo en diabetes
Authors: Tovar Cortés Henry 
Published: August 2021

Según la Federación Internacional de Diabetes, aproximadamente 463 millones de personas en el mundo viven con diabetes (1), y casi el 7 % de los colombianos también han sido diagnosticados con esta patología (2).
En Colombia, durante 2019, solo el 51,08 % de los 1,3 millones de pacientes del sistema de salud podían controlar la hemoglobina glucosilada (HbA1c), lo cual constituye una señal preocupante, ya que la falta de control de esta proteína se ha relacionado con otras afecciones como eventos cerebrovasculares (3).
Obituario, Dr. Bernardo Reyes Leal (Q.E.P.D.)
Authors: Páez Talero Amanda 
Published: August 2021

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El pasado 21 de enero de 2021 registramos con gran pesar el fallecimiento de nuestro profesor y mentor, el Dr. Bernardo Reyes Leal, endocrinólogo, miembro honorario y expresidente de la Asociación Colombiana de Endocrinología, Diabetes y Metabolismo (ACE), profesor emérito de la facultad de Medicina de la Universidad Nacional, fundador junto con otros reconocidos colegas de la Asociación Colombiana de Medicina Interna (ACMI), y desde su regreso a Colombia en el año de 1962, impulsor y colaborador incansable en el progreso y la evolución de nuestra Asociación, en la que además creó y promovió sus publicaciones, incluida esta revista. El Dr. Bernardo Reyes Leal realizó sus estudios de medicina en Francia y a su regreso fue seleccionado dentro de un grupo de profesores de la Universidad Nacional para complementar sus estudios de endocrinología en la Universidad de Ann Arbor en Michigan, bajo la tutoría del Dr. Jerome W. Conn, descubridor del hiperaldosteronismo primario. A su regreso a Colombia y como profesor titular de Endocrinología en el Hospital San Juan de Dios de Bogotá, se dedicó al desarrollo científico y académico de la especialidad, dando un énfasis incomparable a la investigación y siendo promotor del desarrollo de la medicina nuclear en el Hospital y posteriormente del laboratorio hormonal, incluido el montaje del radioinmunoensayo, que permitió las primeras mediciones de hormonas por este método en el país.
Eficacia y seguridad de liraglutida para la disminución de peso en adultos: revisión sistemática
Authors: Hernández Rodríguez DC , Monroy Sánchez DC , Porras Ramírez A. 
Published: August 2021

Objetivo: evaluar la eficacia y seguridad de liraglutida como medicamento coadyuvante para disminuir el índice de masa corporal (IMC) en personas con sobrepeso y obesidad a nivel mundial.
Materiales y métodos: se realizó la búsqueda de estudios en las bases de datos (TRIP, Embase, Pubmed, Scopus, Epistemonikos, Cochrane y ClinicalKey), cuyo desenlace por evaluar sea la disminución de peso con el uso de liraglutida. Lo anterior se realizó mediante la herramienta PRISMA 2009 con el fin de obtener una revisión sistemática.
Resultados: de un total de 74 estudios, se incluyeron 3 ensayos clínicos aleatorizados que evaluó un total de 4281 participantes. Se evaluó como desenlace principal la disminución de peso y los eventos adversos presentados fueron los desenlaces secundarios. Se realizó un metaanálisis cuyo reporte de pérdida de peso de -5,22 (intervalo de confianza [IC] del 95 %: -5,95, -4,50) y el índice de inconsistencia (I²) mostró alta heterogeneidad, al igual que la metarregresión realizada. Los eventos adversos se evidenciaron con mayor frecuencia en el grupo de liraglutida, y los eventos gastrointestinales fueron los más reportados.
Conclusión: los resultados individuales en los estudios demuestran que el uso de liraglutida disminuye el peso. Sin embargo, en esta revisión sistemática se evidencia que no hay una significancia estadística de la evidencia por heterogeneidad de los estudios evaluados.
Impacto da Radiodermatite na estética corporal de pacientes com câncer de cabeça e pescoço
Authors: Cabral Bárbara De Sousa , Reis Paula Elaine Diniz dos , Ferreira Elaine Barros 
Published: August 2021

Objetivo: descrever o impacto da radiodermatite na estética corporal em pacientes com câncer de cabeça e pescoço submetidos à radioterapia. Método: estudo exploratório descritivo, do tipo série de casos, realizado no ambulatório de radioterapia de um hospital de ensino. Foram incluídos dez pacientes com câncer de cabeça e pescoço que foram submetidos à radioterapia no período de 2015 a 2017. A coleta dos dados foi realizada com instrumento construído para esse fim e por meio de registro fotográfico. Os dados foram analisados de forma descritiva, apresentando-se o cálculo da frequência. Resultados: todos os pacientes apresentaram sinais característicos de radiodermatite, principalmente os sinais clínicos de epilação (nos homens), hiperpigmentação e descamação seca, que afetam a estética corporal. Conclusão: a estética corporal dos pacientes acompanhados foi alterada em decorrência dos sinais clínicos da radiodermatite. Destaca-se a importância de avaliar essas alterações em pacientes com câncer de cabeça e pescoço submetidos à radioterapia.
Congruence between morphology-based species and Barcode Index Numbers (BINs) in Neotropical Eumaeini (Lycaenidae)
Authors: Prieto Carlos , Faynel Christophe , Robbins Robert , Hausmann Axel 
Published: August 2021

BackgroundWith about 1,000 species in the Neotropics, the Eumaeini (Theclinae) are one of the most diverse butterfly tribes. Correct morphology-based identifications are challenging in many genera due to relatively little interspecific differences in wing patterns. Geographic infraspecific variation is sometimes more substantial than variation between species. In this paper we present a large DNA barcode dataset of South American Lycaenidae. We analyze how well DNA barcode BINs match morphologically delimited species.MethodsWe compare morphology-based species identifications with the clustering of molecular operational taxonomic units (MOTUs) delimitated by the RESL algorithm in BOLD, which assigns Barcode Index Numbers (BINs). We examine intra- and interspecific divergences for genera represented by at least four morphospecies. We discuss the existence of local barcode gaps in a genus by genus analysis. We also note differences in the percentage of species with barcode gaps in groups of lowland and high mountain genera.ResultsWe identified 2,213 specimens and obtained 1,839 sequences of 512 species in 90 genera. Overall, the mean intraspecific divergence value of CO1 sequences was 1.20%, while the mean interspecific divergence between nearest congeneric neighbors was 4.89%, demonstrating the presence of a barcode gap. However, the gap seemed to disappear from the entire set when comparing the maximum intraspecific distance (8.40%) with the minimum interspecific distance (0.40%). Clear barcode gaps are present in many genera but absent in others. From the set of specimens that yielded COI fragment lengths of at least 650 bp, 75% of thea priorimorphology-based identifications were unambiguously assigned to a single Barcode Index Number (BIN). However, after a taxonomica posteriorireview, the percentage of matched identifications rose to 85%. BIN splitting was observed for 17% of the species and BIN sharing for 9%. We found that genera that contain primarily lowland species show higher percentages of local barcode gaps and congruence between BINs and morphology than genera that contain exclusively high montane species. The divergence values to the nearest neighbors were significantly lower in high Andean species while the intra-specific divergence values were significantly lower in the lowland species. These results raise questions regarding the causes of observed low inter and high intraspecific genetic variation. We discuss incomplete lineage sorting and hybridization as most likely causes of this phenomenon, as the montane species concerned are relatively young and hybridization is probable. The release of our data set represents an essential baseline for a reference library for biological assessment studies of butterflies in mega diverse countries using modern high-throughput technologies an highlights the necessity of taxonomic revisions for various genera combining both molecular and morphological data.
Eating for numbing: a community-based study of trauma exposure, emotion dysregulation, dissociation, body dissatisfaction and eating disorder symptoms
Authors: Lev-ari Lilac , Zohar Ada H. , Bachner-Melman Rachel 
Published: August 2021

Objective
The current study tests the relationship between eating disorder (ED) symptoms and trauma exposure. The mechanisms via which trauma is related to ED symptoms have not been sufficiently examined. This study examines the complex role of dissociation and emotional dysregulation in the context of trauma, BMI, ED symptoms and body dissatisfaction (BD). We hypothesized that dissociation and emotional dysregulation would mediate the relationship between trauma exposure and ED symptoms/BD. We further hypothesized that BMI would play a moderating role in this association.

Method
A community sample of 229 (16.2% male) participants, with a mean age of 29.08 ± 10.68 reported online on traumatic events (Life Events Checklist), dissociation (Dissociative Experiences Scale-II), emotional dysregulation (Difficulties in Emotional Regulation Scale), ED symptoms (Eating Disorders Examination-Questionnaire) and BD (Figure Rating Scale).

Results
Participants reported experiencing a mean of 2.87 ± 2.27 traumatic events, with a relatively high percentage (~86%) reporting at least one. The most commonly reported traumatic events were transportation accidents and physical assault. Although frequency of traumatic events did not directly predict ED symptoms, BMI, dissociation, emotional dysregulation and BD did. An SEM model showed that traumatic events predicted ED symptoms indirectly through dissociation, emotional dysregulation and BMI. Dissociation and emotional dysregulation predicted ED symptoms directly. BMI also moderated the association between traumatic events and both ED symptoms and BD.

Conclusions
Therapists treating patients with high BMI or obesity should be aware of these relationships and investigate the possibility that trauma and/or PTSD may underlie the presenting disordered eating or eating disorder.
Characteristics of ESRD Patients who have been on Long-term Hemodialysis Therapy in Egypt
Authors: Megahed Abir Farouk , Sayed-Ahmed Nagy 
Published: August 2021

Background: It is well-known that hemodialysis extends the life of end-stage renal disease (ESRD) patients, who would have otherwise died. The characteristics of long-term patients on hemodialysis (HD) were not evaluated before in Egypt. We aimed at identifying the specific characteristics of the patients who have survived on hemodialysis for more than 20 years in Egypt. Subjects and Methods: During the years 2018 and 2019, the twenty-seven governorate health affairs Directories of the Egyptian Ministry of Health were contacted to participate in data collection. The dialysis physicians in each hemodialysis unit were sent a questionnaire form requesting to submit information, on the characteristics of patients who have been on HD therapy for twenty years or more.
Results: Seventy-three patients were encountered from a total number of 26000 HD patients to have been on HD therapy; with a range between 20 and 30 years. Males constituted the majority of these patients. Sixty-eight patients were dialyzed through working arteriovenous fistulas (A-V fistulas). The mean urea reduction ratio (URR) of these patients was 0.65±0.095. Acute intradialytic complications afflicted only 20.3% of these patients. More than three-quarters of the patients had a positive serology test for HCV antibodies. None of these patients has diabetes mellitus. On the other hand, complaints related to the skeletal system were present in 47.4% of the patients. There is a statistically significant higher rate of acute complications in the female gender and a statistically significant higher fertility rate after hemodialysis in the male gender.
Conclusion: Long-term dwellers on hemodialysis therapy are not unusual in Egyptian ESRD patients and their characteristics are reasonable.
Evaluation of Parent's Knowledge About Fever
Authors: Hafidi Najlae El , Mekaoui Nour , Dakhama Badr Sououd Benjelloun , Karboubi Lamya 
Published: August 2021

Introduction: Fever in children is the most frequent reason for pediatric consultation. Aims of the Study: To assess parent's knowledge and behavior regarding fever in children before the consultation.
Methodology: This survey was carried out among 614 who agreed to answer a pre-established questionnaire, having consulted in the pediatric medical emergency department of the children's hospital in rabat.
Results: Fever was defined in 64.2% of parents as a temperature above the threshold of 38 ° C. It was measured in 37.9% of cases by the axillary method, the drugs most used were paracetamol and ibuprofen, with the use of paracetamol first in 73.9%, the administration of the drug was based of the weight in 58.7%. Angina was considered the most likely cause of fever (72.7% of cases).
Conclusion: The results of our survey show the need to improve parent's knowledge of fever as well as its management at home.
A Case Report on Mucormycosis in Non-Diabetic, Non-Covid Recovered Patient with no History of Steroid use
Authors: Panduranga Gautam , Kumar Bavu Akhil , Krishna Mandhala Sai , Aakunuri Akhil , Godishala Nikitha 
Published: August 2021

Rhino cerebral orbital mucormycosis is an aggressively spreading fungal infection caused by filamentous fungi of the Mucoraceae family and is found to be more prone in patients with comorbidities that include: uncontrolled diabetes mellitus, immune-suppressed patients, iron and aluminum overload, chronic steroid therapy, severe trauma, and protein-energy malnutrition.
A 51year old male patient was admitted to the hospital with a complaint of headache and intermittent fever. The patient had no history of diabetes or denovo hypertension. Based on the analysis of histopathological and radiological investigations, the patient was diagnosed with mucormycosis. The patient furthermore underwent an endoscopic surgical debridement followed by standard treatment including antifungal antibiotic(amphotericin-B) and azole antifungals (posaconazole) along with symptomatic treatment. Though the patient was given all possible therapy available, no improvement was seen in the patient's condition (poor prognosis).
Decentralized adaptive terminal sliding mode control design for nonlinear connected system in the presence of external disturbance
Authors: Ranjbar Babak , Ranjbar Noiey Abolfazl , Rezaie Behrooz 
Published: August 2021

SummaryIn this article, a decentralized adaptive integral terminal sliding mode control is presented for a class of nonlinear connected systems. It is assumed that the system is also confronted by unknown disturbances, while the interconnections between subsystems are assumed unknown. An integral terminal sliding surface for each subsystem is locally considered to guarantee the stability of the closed‐loop system, and to increase the convergence speed during a tracking task. The unknown interconnections between subsystems are estimated using adaptive rules. An appropriate Lyapunov candidate is chosen to perform global stability analysis. In this regard, design parameters are chosen such that the closed‐loop stability is ensured. Performance of the proposed method for a mechanical connected system, including two chaotic subsystems, is shown through simulations.
Unraveling Three‐Stage Discharging Behaviors of Bio‐Inspired Organic Cathode Materials
Authors: Jung Ku Hyun , Lim Sohee , Choi Siku , Kim Ki Chul 
Published: August 2021

AbstractDespite the creativity in designing materials based on bio‐inspired organic compounds and their potential structural diversity, the incorporation of such materials into cathodes has attracted scarce attention, principally due to intrinsically weak redox activities. Herein, a large number of DNA/RNA‐inspired derivatives are systematically designed, and their electrochemical redox properties are explored with the aim of understanding structure–potential–performance relationship. Four striking conclusions can be drawn from this study. First, charging energy describing the 1st reduction step is a decisive parameter for the open‐circuited adiabatic redox potentials of the compounds in the fully charged states, indicating that reorganization energy in the 2nd reduction step has a negligible impact. Second, both the charging and reorganization energies contribute cooperatively to the discharging potentials. Third, the compounds become cathodically inactive at the end of the discharging process owing to a sudden increase in solvation energy; thus, the compounds exhibit “three‐stage discharging behavior”. Fourth, the charge/energy‐storage capability shows a critical dependence on Li binding mechanism, which is in turn correlated with the afore‐mentioned core factors, leading to exceptional performance for a guanine derivative (1190 and 1586 mWh g−1). These findings will aid in advancing the development of bio‐inspired cathode materials for high‐performance Li‐ion batteries.
A Memristor‐Based Silicon Carbide for Artificial Nociceptor and Neuromorphic Computing
Authors: Liu Lu'an , Zhao Jianhui , Cao Gang , Zheng Shukai , Yan Xiaobing 
Published: August 2021

AbstractWith the advancement of artificial intelligence technology, more and more biological functions need to be imitated to complete more complex tasks and adapt to a complex external work environment. Memristors, as an excellent candidate for neuromorphic artificial electronic devices with many biological functions, have inspired the interest of researchers because of the advantages of scalability, good retention, and high operating speed. In this work, wide band gap semiconductor materials silicon carbide (SiC) films are prepared as a memristor medium. By adjusting the current compliance, both threshold character and bipolar resistive switching phenomenon are realized in one device with both lower powers for set operation. For the threshold characteristic, this device has mimicked the “threshold,” “inadaptation,” and “relaxation” features of a nociceptor, which will protect the artificial intelligence system to have stronger adaptability to the external environment. For the bipolar resistive switching characteristics, this device demonstrates good stability and retention time, with a switching speed of 18 ns. These bipolar resistance switching characteristics have simulated many synaptic functions. Pulses with hundreds of nanosecond time scale widths are conducive to fast learning and calculation. This device‐based third‐generation SiC semiconductor material will find a broad application in neuromorphic chip systems.
Proteome‐Wide Profiling of Readers for DNA Modification
Authors: Bai Lin , Yang Guojian , Qin Zhaoyu , Lyu Jiacheng , Wang Yunzhi , Feng Jinwen , Liu Mingwei , Gong Tongqing , Li Xianju , Li Zhengyang , Li Jixi , Qin Jun , Yang Wenjun , Ding Chen 
Published: August 2021

AbstractDNA modifications, represented by 5‐methylcytosine (5mC), 5‐hydroxymethylcytosine (5hmC), 5‐formylcytosine (5fC), and 5‐carboxylcytosine (5caC), play important roles in epigenetic regulation of biological processes. The specific recognition of DNA modifications by the transcriptional protein machinery is thought to be a potential mechanism for epigenetic‐driven gene regulation, and many modified DNA‐specific binding proteins have been uncovered. However, the panoramic view of the roles of DNA modification readers at the proteome level remains largely unclear. Here, a recently developed concatenated tandem array of consensus transcription factor (TF) response elements (catTFREs) approach is employed to profile the binding activity of TFs at DNA modifications. Modified DNA‐binding activity is quantified for 1039 TFs, representing 70% of the TFs in the human genome. Additionally, the modified DNA‐binding activity of 600 TFs is monitored during the mouse brain development from the embryo to the adult stages. Readers of these DNA modifications are predicted, and the hierarchical networks between the transcriptional protein machinery and modified DNA are described. It is further demonstrated that ZNF24 and ZSCAN21 are potential readers of 5fC‐modified DNA. This study provides a landscape of TF–DNA modification interactions that can be used to elucidate the epigenetic‐related transcriptional regulation mechanisms under physiological conditions.
Fixes that Fail: A system archetype for examining racialized structures within the food system
Authors: Benninger Elizabeth , Donley Gwendolyn , Schmidt‐Sane Megan , Clark Jill K. , Lounsbury David W. , Rose Dominque , Freedman Darcy 
Published: August 2021

AbstractAccess to fresh and healthy food within a neighborhood has been identified as a social mechanism contributing to community health. Grounded in the understanding that challenges related to equity within a food system are both structural and systemic, our research demonstrates how systems thinking can further understandings of food system complexity. Within systems thinking, we provide an illustration of how system archetypes offer an analytic tool for examining complex community issues. We map semi‐structured interview data from community stakeholders (N = 22) to the “Fixes that Fail” system archetype to illuminate systemic challenges, such as incarceration and poverty, that structure food system inequity in urban communities. Within our research, the “Fixes that Fail” archetype provided a narrative interpretive tool for unveiling complexity within the food system and interdependencies with racialized systems such as criminal justice and labor markets. This system archetype provided an accessible approach for generating narratives about systemic complexity, the production of inequity through racialized forces, and opportunities for transformation.