bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: From Books to Bedside: Analyzing Learning Strategies for Conceptual Medical Knowledge among Medical Students at Umm Al-Qura University, Saudi Arabia
Authors: Saleh Saleh Ahmed K. , Adly Heba Mohamed 
Published: January 2025

Hereby, Bali Medical Journal stated that the article with details below:
ID : 4773
Title : From Books to Bedside: Analyzing Learning Strategies for Conceptual Medical Knowledge among Medical Students at Umm Al-Qura University, Saudi Arabia
Authors: Saleh Ahmed K. Saleh; Heba Mohamed Adly
This article has been retracted from Bali Medical Journal effectively from April 4th,2024.
Chronology and cause of retraction: Strong evidence of plagiarism.
This article was accepted by Bali Medical Journal because it had passed the pre-review screening (including plagiarism check), editorial evaluation, and double blind peer review process.
However, a report by authors from article entitled “How do medical students learn conceptual knowledge? High-, moderate- and low-utility learning techniques and perceived learning difficulties” authored by Anne Franz; Sebastian Oberst; Harm Peters; Ralph Berger; Ronja Behrend (https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-022-03283-0), raised our concern about the article and the editorial board underwent several in depth evaluations regarding the plagiarism suspicion (comparison evidence from the authors of this journal attached). Indeed, the reviewers and editors found that there are strong signs of plagiarism in the aforementioned article, especially in the result section, in which the analytical values are exactly the same as the second article published in BMC. The editorial board considered that this is highly unusual and even by chance, deemed impossible. Therefore, the editorial board of Bali Medical Journal has decided to retract the article and published a letter of retraction including the evidence of plagiarism.
We hope that the readers understand the current circumstances of this article and read with caution. This response by Bali Medical Journal is conveyed as our commitment to uphold publication integrity.
The effect of anthracycline chemotherapy on reducing left ventricular ejection fraction in breast cancer patients at Putri Bidadari Hospital Stabat
Authors: Rizka Adi , Millizia Anna , Wahyuni Hendra , Farziani Hayatul , Syahril Khairunnisa 
Published: January 2025

Link of Video abstract: https://youtu.be/tAnMomyDnF0

Introduction: Breast cancer is the most common cancer and also the leading cause of death from cancer in women. Anthracycline chemotherapy is one of the most effective chemotherapy agents and is often used in the treatment of breast cancer. However, its use can cause cardiotoxicity which is characterized by a decrease in LVEF. Regulation of the Minister of Health of the Republic of Indonesia states that breast cancer patients who receive anthracycline chemotherapy must have an echocardiography examination after 2 cycles. This study aimed to assess the effect of anthracycline chemotherapy on reducing LVEF in breast cancer patients.
Methods: This study was an observational study with a cross-sectional design. The data used was secondary data in the form of LVEF values of breast cancer patients before being given anthracycline dose chemotherapy with 60 mg/m2 of body surface area (BSA), after being given 2 cycles and after 4 cycles with a total of 22 respondents. Data were analyzed using the Paired T-test. The limitations of this study were small sample size (22 patients) and study was limited to only one hospital.
Results: The results of this study obtained p values for LVEF 1-LVEF 2 of 0.748 and LVEF 2-LVEF 3 of 0.215 with an average decrease in LVEF of 0.318% for LVEF 1-LVEF 2 and 1.409% for LVEF 2 and LVEF 3 with p value 0.000 and 0.001.
Conclusion: Based on the results of this study it is known that there are differences in LVEF values before and after administration of chemotherapy but there are no significant differences and cannot be classified as cardiotoxicity so that echocardiographic examinations in patients in close proximity are not effective enough to detect anthracycline-induced cardiotoxicity.
Nasopharyngeal histopathology of Wistar rats induced by formaldehyde with tiered concentration
Authors: Wedayani Anak Agung Ayu Niti , Abdul Qadar Punagi  , Pieter Nova Audrey Luetta , Muhammad Husni Cangara  , Kristin Erna , Kadriyan Hamsu , Rohadi  , I Made Tobias Abdiman  
Published: January 2025

Link of Video Abstract: https://youtu.be/XDoTlhAvGKo

Background: Formaldehyde is a substance that can damage cell structures because it has irritant and carcinogenic effects. Formaldehyde can cause several adverse effects by injuring various tissues, impairing the regulation of energy metabolism, and reducing the body's antioxidant capacity. This study aims to assess the severity of cellular changes and the time required for the occurrence of nasopharyngeal dysplasia after formaldehyde induction over a different period.
Methods: Twenty Wistar rats were divided into control and three treatment groups with 20, 30, and 40 ppm formaldehyde concentration induction. Every sample in the group will be terminated every four weeks for sixteen weeks. Nasopharynx samples were examined under the light microscope with H&E staining to identify severity differentiation between the control and treatment groups. We used the cellular and architectural dysplasia grading system as the reference for histopathological results.
Results: There was a significant difference between the treatment groups and the severity of dysplasia (p=0.007) but an insignificant difference between the week of termination and the severity of dysplasia (p=0.407). Histopathological results showed no specific mark of cellular changes from every degree of dysplasia.
Conclusion: This study showed that a higher formaldehyde concentration could cause more damage to cellular morphology. The longer formaldehyde is exposed in any dose, the more cellular damage occurs in the nasopharynx of Wistar rats.
Model prediction formulation of antibiotic type and length of treatment for pediatric typhoid fever patients at Cut Mutia General Hospital, North Aceh, Indonesia
Authors: Yuziani  , Sofia Rizka , Utariningsih Wheny , Adri  , Faddhillah Siti Ghina 
Published: January 2025

Link of Video Abstract: https://youtu.be/Tnam4IeVlsc

Introduction: Aceh Province is one of the provinces that has the highest typhoid fever cases in Indonesia and North Aceh district is also the number one highest district in Aceh province, this is certainly a special concern in dealing with the problem of appropriate antibiotic use and has effectiveness in predicting length of hospitalization. Antibiotics are drugs of the antimicrobial compound class that are generally used for bacterial infections. The use of antibiotics with good effectiveness can further shorten the length of hospitalization. This can save costs and time in the length of hospitalization, researchers want to see the effectiveness of antibiotics as a predictor of the length of treatment of pediatric typhoid fever patients at Cut Mutia General Hospital, North Aceh. This study aims to assess the effectiveness of antibiotics as a predictor of the length of treatment of pediatric typhoid fever patients at Cut Mutia General Hospital, North Aceh.
Patients and methods: The method researchers took data sources from the medical records of typhoid fever patients in children who fit the inclusion criteria, the data amounted to 160 samples and then analyzed univariate and bivariate data. All analyses considered significant if p<0.05
Results: The results showed that the characteristics of patients with typhoid fever were mostly female (63.8%) and had an age mostly in the school-age category (66.9%). The length of treatment in pediatric typhoid fever patients is mostly less than 7 days (84.4%) and the type of antibiotic used most widely used is Ceftriaxone (59.4%), more toddlers have a length of treatment of fewer than 7 days (92.3%) compared to pre-school age and school age, While school age has more length of treatment more than 7 days (18.7) than a toddler and pre-school age and female gender has more length of treatment less than 7 days (86.3%) than male, while men have more length of treatment more than 7 days (19%). Patients who used Ceftriaxone antibiotics had a longer stay of less than 7 days (87.4%) compared to other types, while patients who used Ciprofloxacin antibiotics had a longer stay of more than 7 days.
Conclusion: The type of antibiotic has a significant relationship with length of stay where Ceftriaxone antibiotics have a 2 times risk of having a length of stay of less than 7 days and age and type of antibiotic can predict the length of stay in typhoid patients.
Pediatric neuromyelitis optica spectrum disorder: Case report of postrema syndrome
Authors: Puspitasari Vivien , Goenawan Vonny Fibrianty , Solansa Tracy , Cenweikiawan Anderson 
Published: January 2025

Link of Video Abstract: https://youtu.be/w-yWNre4RNg

Introduction: Neuromyelitis Optica Spectrum Disorders (NMOSD) is an inflammatory disease of the optic nerve and spinal cord characterized by severe immune mediated axonal damage and demyelination. Optic neuritis, transverse myelitis, or combination of both are common first clinical attack symptoms. Area postrema syndrome was infrequently described as an initial presentation of pediatric NMOSD.
Case Presentation: We present the case of 10-year-old male presents with fever, nausea, vomiting, hiccups, and vertigo suggesting an Area Postrema Syndrome. Brain Magnetic Resonance Imaging (MRI) with contrast shows a pathological lesion without contrast enhancement on the periventricle of the 3rd ventricle extends to the bilateral optic tracts. Whole spine MRI showed no abnormalities. Aquaporin-4 was found seropositive on lumbar puncture examination. He was treated with intravenous methylprednisolone for 5 consecutive days followed by IVIG for 5 days and mycophenolate mofetil as maintenance therapy. Patient then showed a significant improvement in symptoms.
Conclusion: Pediatric NMOSD with core criteria of area postrema syndrome as the first clinical attack is rare. Relapse may occur, requiring further follow-up and maintenance therapy. We should raise awareness on the possibility of postrema syndrome in pediatric NMOSD cases that are intractable with medication.
Admission C-reactive protein, D-dimer, IL-6 and XCL1/lymphotactin levels as predictors of 28-day mortality in COVID-19 patients: a prospective cohort study
Authors: Susilo Adityo , Pohan Herdiman Theodorus , Rumende Cleopas Martin , Rengganis Iris , Harahap Alida , Kekalih Aria , Wulandari Dewi , Sahbandar Ivo Novita , Suwarto Suhendro 
Published: January 2025

Link of Video Abstract: https://youtu.be/cQUhwa50jAM

Background: Predictors of mortality in COVID-19 patients, which are essential factors in guiding patient management, are poorly understood. In Indonesia, several inflammatory markers have been utilized to evaluate the severity of COVID-19. This study aimed to determine the role of C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), and XCL1/lymphotactin levels in predicting 28-day mortality in patients with COVID-19.
Methods: A prospective cohort study was conducted with COVID-19 patients admitted to the emergency department at Cipto Mangunkusumo Hospital and Medistra Hospital, Jakarta, Indonesia, from June 2020 to February 2021. The predictors of 28-day mortality in COVID-19 patients in this study included CRP, D-dimer, IL-6, and XCL1 levels at admission. Cox proportional hazard regression analysis was used to determine the independent predictors of 28-day mortality in the study population.
Results: A total of 120 patients with COVID-19 were enrolled in the study; 21 (17.5%) died within 28 days after admission. According to our multivariate analysis, a CRP level (HR, 8.55; 95% CI, 3.310-22.088) ≥ 110 mg/L and a D-dimer level (HR, 20.642; 95% CI, 6.909-61.667) ≥ 4640 ng/mL were identified as independent predictors of 28-day mortality in COVID-19 patients.
Conclusion: A C-reactive protein level ≥ 110 mg/L and a D-dimer level ≥ 4640 ng/mL can be used to predict 28-day mortality in COVID-19 patients.
Safety and efficacy holmium laser lithotripsy for bladder stones: Initial experience at a single center in Koja General Hospital
Authors: Wijaya J Rahendra , Hariwibowo Rinto , Sutarto Waluyo Eko , Akbar Nurul 
Published: January 2025

Introduction: Bladder stones, a common urological condition, can significantly impact a patient's quality of life, leading to symptoms such as obstructive lower urinary tract symptoms (LUTS) and hematuria. In recent years, the utilization of laser lithotripsy has emerged as a promising technique for the removal of bladder stones, offering potential advantages in terms of efficacy and safety.
Methods: Data obtained from the medical record was collected retrospectively since the use of laser lithotripsy in 2019. Patients who fulfilled the inclusion and exclusion criteria were included. Data on patients’ age, sex, symptoms, maximum stone diameter, operation duration, complications, and length of in-hospital duration were gathered and analyzed. The primary endpoint was to assess the stone size being successfully removed and procedure duration.
Results: We recruited 46 participants (40 men and 6 women) with a mean age of 55.5 years old. In 18 (39%) participants, obstructive LUTS was the main presenting symptom, followed by hematuria in 9 (19%) patients. In 10 (28%) of cases, work-up was done by plain abdominal x-ray, while the remaining 36 (72%) underwent CT-scan. The mean surgery duration was 57.2 ± 22.3 minutes. Out of subjects, 3 (6.5%) experienced hematuria as a side effect while 1 (2.1%) patient had a fever.
Conclusion: Our data demonstrated a safe and effective result of laser lithotripsy used for bladder stones removal. More research is warranted to compare the current modality applied in Indonesia general hospitals along with cost analysis to provide the best treatment option for the patients.
Correlation Between Serum Calcium and Parathyroid Hormone in Chronic Kidney Disease Patients
Authors: Harli Wahyudi Pratama , Hasyim Kasyim  , Pendrik Tandean  , Syakib Bakri  , Nur Ahmad Tabri  , Arifin Seweng  
Published: January 2025

Introduction: Chronic kidney disease (CKD) is commonly associated with secondary hyperparathyroidism. Elevated phosphorus concentrations and decreased synthesis of active vitamin D (calcitriol) as a direct result of impaired renal function induce a cascade of symptoms, including decreased calcium absorption and increased parathyroid hormone (PTH) secretion. This study aimed to assess the association between calcium levels and PTH levels in patients diagnosed with CKD.
Methods: A cross-sectional observational study was conducted involving a cohort of 80 individuals diagnosed with CKD who met the established criteria. The statistical tests employed in this study were Pearson's correlation. Statistically significant findings are obtained from these tests when the p-value is below 0.05.
Results: This study demonstrates a correlation between decreased levels of calcium in the blood and increased levels of PTH in persons with impaired kidney function. In eighty patients with CKD stages 3 to 5, regardless of dialysis status, a clear inverse correlation (-0.328, P = 0.000) was observed between parathyroid hormone and serum calcium levels.
Conclusion: Patients with CKD showed a significant inverse correlation between their blood serum calcium levels and PTH levels. Hence, it is imperative to assess the concentrations of blood calcium and PTH in individuals with CKD and a glomerular filtration rate below 60 ml/min/1.73 m2.
Effect of scalp block with 0.5% ropivacaine on interleukin-6 and neutrophil lymphocyte ratio in elective craniotomy
Authors: Desiree Pricilia , Airlangga Prananda Surya , Kriswidyatomo Prihatma , Waloejo Christrijogo Soemartono , Hamzah  , Santosa Dhania A. , Semedi Bambang Pujo , Susila Dedi , Komarulloh Noor Syamsu , Karamoy Ovi Octavia , Lestari Pudji , Pandi Moses Glorino Rumambo 
Published: January 2025

Background: In recent decades, the study of immunology has evolved rapidly, elucidating the cellular and molecular mechanisms underlying human immunity. Recent studies have shown that high levels of cytokines correlate with the degree of manipulation of brain tissue and lower levels of inflammation in brain tumor surgery are associated with higher safety rates. The use of scalp block in craniotomy surgery is associated with the modulating effect of both local and systemic inflammatory responses. This study aims to analyze the effect of scalp block with 0.5% ropivacaine on IL-6 and NLR in elective craniotomy surgery.
Method: A randomized controlled trial (RCT) was conducted at Dr. Soetomo General Hospital Surabaya with a total of 40 patients who underwent elective craniotomy from September to November 2023. Patients were divided into two groups: the scalp block (SB) group and the non-scalp block (non-SB) group. All patients were under general anesthesia and a scalp block was added to the SB group after general anesthesia. IL-6 concentration and NLR count were assessed after general anesthesia (T0), 6 hours after incision (T1), and 24 hours after surgery (T2).
Results: IL-6 and NLR levels increased over time and reached their peak at 24 hours after surgery in both groups with IL-6 SB: 83.50 ± 2,289 pg/mL and IL-6 non-SB: 84,638 ± 2.25 pg/ml. NLR SB: 6.80 ± 1.17 and NLR non SB: 7.33 (5.83-8.09). In the comparative test, there was a significant difference in IL-6 and NLR levels at 6 hours after incision (p:<0.001 and p=0.0015), and significant differences in changes IL-6 baseline and 6 hours after incision (∆T0-T1) (P:<0.001). However, there was no significant difference in IL-6 and NLR levels at 24 hours after surgery and no significant difference in the changes between IL-6 baseline and 24 hours after surgery (∆T0-T2), NLR baseline, and 6 hours after incision (∆T0-T1), NLR baseline and 24 hours after surgery (∆T0-T2) between two groups.
Conclusion: Scalp block suppresses pro-inflammatory mediators for only 6 hours after incision. It is most effectively used in short procedures, as an adjuvant for the head pinning procedure or incision.
The effects of Epigallocatechin-3-Gallate (EGCG) to the expression of Basic Fibroblast Growth Factor (bFGF) and detection of cell apoptosis in Human Pterygium Fibroblast (HPF) cells
Authors: Ayunda Astry , Indriaswati Luki , Firmansjah Muhammad , Purwanto Djoko Agus , Utomo Budi 
Published: January 2025

Link of Video Abstract: https://youtu.be/tiaUvh3apW8Background: Pterygium is a prevalent ocular health issue. The efficacy of surgical procedures as the primary therapeutic approach has been limited, particularly in preventing its recurrence. Basic Fibroblast Growth Factor (bFGF) plays a significant role in the progression of chronic inflammation and DNA damage, leading to the invasion of pterygium cells. Epigallocatechin-3-gallate (EGCG) demonstrated the ability to decrease recurrence of human pterygium fibroblast (HPF) and inhibit cell migration in vitro, while preserving the integrity of conjunctival cells. This study aimed to examine the impact of EGCG on the expression of bFGF and cell apoptosis in HPF.
Methods: The experimental study with a randomized posttest only control group design was used to examine the expression of bFGF and cell apoptosis on HPF across 5 treatment groups. These groups included a control group (-), treatment groups receiving Mytomicin-C 0.4 mg/ml, as well as EGCG 50 µM, 100 µM, and 150 µM. Cell apoptosis was assessed by a flow cytometry instrument, while bFGF was accomplished by immunofluorescence staining.
Results: The results showed a significant decrease in bFGF expression in HPF cells among the control group (-), Mitomycin-C group and EGCG 50, 100, 150 µM group (p<0.01). The mean apoptosis induction of HPF cells after 72 hours in the control group, EGCG 50, 100, and 150 µM and MMC 0.4 mg/ml were respectively 6.1 (SD±0.08); 4.63 (SD±0.91); 20.70 (SD±1.46); 16.20 (SD±0.47); 98.81 (SD±0.16). ANOVA and Tukey posthoc tests showed a significant increase in apoptosis of HPF cells among treatment groups: the control group (-), EGCG 50,100, 150 µM, and MMC 0.4 mg/ml (p<0.01), whereas EGCG 50 caused a decrease of apoptosis compared to control group (-).
Conclusion: There is a significant difference in the expression of bFGF and apoptosis in HPF after administration of EGCG compared to negative controls
The relationship between characteristics and prognostic index of follicular thyroid nodule
Authors: Permana Agung , Wibowo Marjono Dwi , Susilo Dwi Hari 
Published: January 2025

Link of Video Abstract: https://youtu.be/Hb9slIAm55g

Introduction: Determining the risk of recurrence and categorizing patients according to their risk groups is a milestone in managing thyroid nodules. The AMES score is a good prognostic index widely used because it is easy for clinicians to remember. Risk groups for thyroid nodules, according to ATA guidelines for nodule characteristics, are closely related to patient prognosis. The specific use of the AMES score to determine suitability for risk groups and prognostic survival rates has not been widely studied. This study aims to find the relationship between the ATA risk stratification of follicular thyroid nodule characteristics and the AMES prognostic index score and prognostic survival rates in follicular thyroid nodules.
Methods: This study is a retrospective cohort using patient medical record data at Dr. Soetomo General Hospital, Surabaya, during the 5-year research period (2013-2017), followed by 5-year monitoring to determine overall survival and disease-free survival.
Results: AMES scores have a strong relationship with ATA classification ultrasound results. A high-risk AMES score in follicular-type thyroid nodules has a 64x probability of being in the ATA high suspicion category. Overall survival and disease-free survival were higher for lower AMES scores and ATA classifications.
Conclusion: The AMES score can be used to predict prognosis and estimate classification ultrasound results in cases of follicular thyroid nodules.
Analysis of plasma atherogenic index in predicting major cardiovascular events in patients with very high risk of cardiovascular disease receiving high-intensity statin therapy
Authors: Kusyanto Fahmi Abdullah , Heriansyah Teuku , Zulkarnain  , Punawarman Adi , Munirwan Haris 
Published: January 2025

Background: Abnormal Lipid levels have a very strong correlation with ASCVD in relation to atherosclerotic plaque formation. Elevated serum triglyceride levels are also associated with residual risk of ASCVD events. The residual risk of ASCVD is the majority result of elevated TG and low HDL-C levels. Another study, further revealed that metabolic HDL-C levels also play an important role in ASCVD. The triglyceride to HDL cholesterol ratio or paslma atherogenix index (AIP) is proposed as a marker of plasma atherogenicity and a predictor of cardiovascular risk. Giving statins is one of the standard therapies to lower triglyceride concentrations in sufferers of atherosclerotic cardiovascular disease (ASCVD) to reduce major adverse cardiovascular events (MACE). This study aims to determine changes in AIP after administration of high-sensitivity statins in ASCVD sufferers with and without MACE.
Method: This research is an observational study with a cohort design involving 70 ASCVD sufferers who were given high-intensity statins with an evaluation of the incidence of MACE for 3 months. AIP assessment was carried out before and after administration of high-intensity statins. Mann-Whitney U test analysis and Wilcoxon rank test were used with a confidence level of 95%.
Result: A total of 70 research subjects experienced MACE with an average AIP of 0.48 and there was no difference in the score for patients without MACE (p = 0.947). The AIP value in patients without MACE (n = 27) before therapy was 0.51 and decreased to 0.46 after 3 months of high-intensity statin therapy (p = 0.130).
Conclusion: The AIP value in ASCVD sufferers did not decrease significantly with high-dose statin therapy for 3 months and did not prevent MACE events.