bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the dynamic tourism inter-industry linkages and economic structural changes in Cambodia’s economy
Authors: Hor Chantha 
Published: September 2021

AbstractThis study employs the SAM-based model combining with multiplier product matrix and field of influence approaches. Under three input–output transaction table matrices of the years 2005, 2010, and 2015, these approaches assess the dynamic tourism inter-industry linkages and structural economic changes in Cambodia. We find that the overall inter-industry connection is relatively low. The textile, other manufacturing, and transportation and communication are key sectors. They have the largest coefficient field of influence of changes in the economic system. Tourism has shifted to be a key sector in 2010 and 2015. However, its backward and forward linkages are still small. It is a relatively promising sector generating a large coefficient field of influence of changes, showing less strength of overall connection with other industries. This study may suggest that there would be a need for promoting, encouraging, and investing in key economic sectors. Policy intervention should focus on developing domestic tourism linkages and strengthening inter-industry ties to diversity tourism benefits the local economy.
Disease-induced changes in plant microbiome assembly and functional adaptation
Authors: Gao Min , Xiong Chao , Gao Cheng , Tsui Clement K. M. , Wang Meng-Meng , Zhou Xin , Zhang Ai-Min , Cai Lei 
Published: September 2021

AbstractBackgroundThe plant microbiome is an integral part of the host and increasingly recognized as playing fundamental roles in plant growth and health. Increasing evidence indicates that plant rhizosphere recruits beneficial microbes to the plant to suppress soil-borne pathogens. However, the ecological processes that govern plant microbiome assembly and functions in the below- and aboveground compartments under pathogen invasion are not fully understood. Here, we studied the bacterial and fungal communities associated with 12 compartments (e.g., soils, roots, stems, and fruits) of chili pepper (Capsicum annuumL.) using amplicons (16S and ITS) and metagenomics approaches at the main pepper production sites in China and investigated howFusariumwilt disease (FWD) affects the assembly, co-occurrence patterns, and ecological functions of plant-associated microbiomes.ResultsThe amplicon data analyses revealed that FWD affected less on the microbiome of pepper reproductive organs (fruit) than vegetative organs (root and stem), with the strongest impact on the upper stem epidermis. Fungal intra-kingdom networks were less stable and their communities were more sensitive to FWD than the bacterial communities. The analysis of microbial interkingdom network further indicated that FWD destabilized the network and induced the ecological importance of fungal taxa. Although the diseased plants were more susceptible to colonization by other pathogenic fungi, their below- and aboveground compartments can also recruit potential beneficial bacteria. Some of the beneficial bacterial taxa enriched in the diseased plants were also identified as core taxa for plant microbiomes and hub taxa in networks. On the other hand, metagenomic analysis revealed significant enrichment of several functional genes involved in detoxification, biofilm formation, and plant-microbiome signaling pathways (i.e., chemotaxis) in the diseased plants.ConclusionsTogether, we demonstrate that a diseased plant could recruit beneficial bacteria and mitigate the changes in reproductive organ microbiome to facilitate host or its offspring survival. The host plants may attract the beneficial microbes through the modulation of plant-microbiome signaling pathways. These findings significantly advance our understanding on plant-microbiome interactions and could provide fundamental and important data for harnessing the plant microbiome in sustainable agriculture.
Assessment of effects of total sleep deprivation and subsequent recovery sleep: a methodological strategy feasible without sleep laboratory
Authors: Stroemel-Scheder Cindy , Lautenbacher Stefan 
Published: September 2021

Abstract
Background
Sleep is critical for maintaining homeostasis in bodily and neurobehavioral functions. This homeostasis can be disturbed by sleep interruption and restored to normal by subsequent recovery sleep. Most research regarding recovery sleep (RS) effects has been conducted in specialized sleep laboratories, whereas small, less-well equipped research units may lack the possibilities to run studies in this area. Hence, the aims of the present study were to develop and validate an experimental protocol, which allows a thorough assessment of at-home recovery sleep after sleep deprivation.

Methods
The experimental protocol, comprising one night of baseline sleep (BL) at home, one night of monitored total sleep deprivation and a subsequent recovery night at home, was tested in a sample of 30 healthy participants. Subjects’ fatigue and alertness were assessed prior to and after each night. Sleep at home (BL, RS) was objectively assessed using portable polysomnography. To check whether our at-home sleep assessments yielded results that are comparable to those conducted in sleep laboratories, we compared the sleep data assessed in our study with sleep data assessed in laboratory studies.

Results
Sleep parameters assessed during RS exhibited changes as expected (prolonged total sleep time, better sleep efficiency, slow wave sleep rebound). Sleep parameters of BL and RS were in line with parameters assessed in previous studies examining sleep in a laboratory setting. Fatigue normalized after one night of RS; alertness partly recovered.

Conclusions
Our results suggest a successful implementation of our new experimental protocol, emphasizing it as a useful tool for future studies on RS outside of well-equipped sleep laboratories.
Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study
Authors: Dugan Adam J. , Nelson Peter T. , Katsumata Yuriko , Shade Lincoln M. P. , Boehme Kevin L. , Teylan Merilee A. , Cykowski Matthew D. , Mukherjee Shubhabrata , Kauwe John S. K. , Hohman Timothy J. , Schneider Julie A. ,   Alzheimer’s Disease Genetics Consortium, Fardo David W. 
Published: September 2021

AbstractLimbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is the most prevalent subtype of TDP-43 proteinopathy, affecting up to 1/3rd of aged persons. LATE-NC often co-occurs with hippocampal sclerosis (HS) pathology. It is currently unknown why some individuals with LATE-NC develop HS while others do not, but genetics may play a role. Previous studies found associations between LATE-NC phenotypes and specific genes: TMEM106B, GRN, ABCC9, KCNMB2, and APOE. Data from research participants with genomic and autopsy measures from the National Alzheimer’s Coordinating Center (NACC; n = 631 subjects included) and the Religious Orders Study and Memory and the Rush Aging Project (ROSMAP; n = 780 included) were analyzed in the current study. Our goals were to reevaluate disease-associated genetic variants using newly collected data and to query whether the specific genotype/phenotype associations could provide new insights into disease-driving pathways. Research subjects included in prior LATE/HS genome-wide association studies (GWAS) were excluded. Single nucleotide variants (SNVs) within 10 kb of TMEM106B, GRN, ABCC9, KCNMB2, and APOE were tested for association with HS and LATE-NC, and separately for Alzheimer’s pathologies, i.e. amyloid plaques and neurofibrillary tangles. Significantly associated SNVs were identified. When results were meta-analyzed, TMEM106B, GRN, and APOE had significant gene-based associations with both LATE and HS, whereas ABCC9 had significant associations with HS only. In a sensitivity analysis limited to LATE-NC + cases, ABCC9 variants were again associated with HS. By contrast, the associations of TMEM106B, GRN, and APOE with HS were attenuated when adjusting for TDP-43 proteinopathy, indicating that these genes may be associated primarily with TDP-43 proteinopathy. None of these genes except APOE appeared to be associated with Alzheimer’s-type pathology. In summary, using data not included in prior studies of LATE or HS genomics, we replicated several previously reported gene-based associations and found novel evidence that specific risk alleles can differentially affect LATE-NC and HS.
Force display control system for simultaneous 3-axis translational motion in surgical training simulator for chiseling operation
Authors: Masuyama Kentaro , Noda Yoshiyuki , Ito Yasumi , Kagiyama Yoshiyuki , Ueki Koichiro 
Published: September 2021

AbstractThe present study proposes an advanced force display control system for a surgical training simulator with virtual reality. In oral and orthopedic surgeries, a surgeon uses a chisel and mallet for chiseling and cutting hard tissue. To enable the representation of force sensation for the chiseling operation in a virtual training simulator, the force display device has been constructed with the ball-screw mechanism to obtain high stiffness. In addition, two-degrees-of-freedom (2DOF) admittance control has been used to react instantaneously to the impactive force caused by pounding with the mallet. The virtual chiseling operation was realized by the force display device with a single axis in the previous studies. In the current study, we propose the design procedure for the force display control system with the 2DOF admittance control approach to virtual operation in three-dimensional space. Furthermore, we propose the design method for the PD controller with imperfect derivative using frequency characteristics for the 2DOF admittance control system. The efficacy of the proposed control system is verified through the virtual experience from manipulating the chisel using the developed force display device in the current study.
Implementation of a cloud-based electronic patient-reported outcome (ePRO) platform in patients with advanced cancer
Authors: Generalova Olga , Roy Mohana , Hall Evan , Shah Sumit A. , Cunanan Kristen , Fardeen Touran , Velazquez Brianna , Chu Gilbert , Bruzzone Bianca , Cabot Anna , Fisher George A. , Srinivas Sandy , Fan Alice C. , Haraldsdottir Sigurdis , Wakelee Heather A. , Neal Joel W. , Padda Sukhmani K. , Johnson Tyler , Heestand Gregory M. , Hsieh Robert W. , Ramchandran Kavitha 
Published: September 2021

Abstract
Background
Patient reported outcomes (PROs) have been associated with improved symptom management and quality of life in patients with cancer. However, the implementation of PROs in an academic clinical practice has not been thoroughly described. Here we report on the execution, feasibility and healthcare utilization outcomes of an electronic PRO (ePRO) application for cancer patients at an academic medical center.

Methods
We conducted a randomized trial comparing an experimental ePRO arm to standard of care in patients with advanced cancer in the thoracic, gastrointestinal, and genitourinary oncology groups at Stanford Cancer Center from March 2018 to November 2019. We describe the pre-implementation, implementation, and post-implementation phases of the ePRO arm, technological barriers, electronic health record (EHR) integration, clinician burden, and patient data privacy and security. Feasibility was pre-specified to be at least 70% completion of all questionnaires. Acceptability was based on patient and clinician feedback. Ambulatory healthcare utilization was assessed by reviewing numbers of phone messages, electronic portal messages, and referrals for supportive care.

Results
Of 617 ePRO questionnaires sent to 72 patients, 445 (72%) were completed. Most clinicians (87.5%) and patients (93%) felt neutral or positive about the ePRO tool’s ease of use. Exposure to ePRO did not cause a measurable change in ambulatory healthcare utilization, with a median of less than two phone messages and supportive care referrals, and 5–6 portal messages.

Conclusions
Web-based ePRO tools for patients with advanced cancer are feasible and acceptable without increasing clinical burden. Key lessons include the importance of pilot testing, engagement of stakeholders at all levels, and the need for customization by disease group. Future directions for this work include completion of EHR integration, expansion to other centers, and development of integrated workflows for routine clinical practice.
Selfie-related concepts and behaviors among Egyptian and Saudi nursing students: a comparative study
Authors: El-slamoni Marwa Abd El-fatah Ali , Ahmed Hanem AbdElkhalek , Arafat Azza Elsayed Abdelfatah 
Published: September 2021

Abstract
Background
Over the last 10 years, social media has become an integral facet of modern society. Self-presentation and body satisfaction are related to social media and its impact on users’ levels of well-being and self-esteem. This study aimed to compare selfie-related concepts (self-esteem and body image) and behaviors (selfie habits and patterns, the motives for using the selfie, and attitude about selfie) between samples of Egyptians and Saudis student nurses. To attain this research aim, a comparative research design study was conducted between 7th of October and 5th of November 2020. This study was conducted in the two countries: Kingdom of Saudi Arabia (KSA) (College of Nursing, Taif University) and Egypt (Faculty of Nursing, Zagazig University). A sample of 300 students was included in two countries: KSA and Egypt. Socio-demographic data sheet, patterns of selfie use scale, self-confidence questionnaire (SCQ), and body image scale.

Results
Results revealed that the Egyptian students were higher in number of selfies per day than Saudi students and the majority of Saudi group like to put their selfies on Instagram.

Conclusion
The current study deduced that Egyptian students as regard selfie habits and patterns had a higher number of selfies per day than Saudi students, also the majority of the Saudi group as regard selfie habits like to put their selfies on Instagram with a statistically significant difference. As regards the motives for using the selfie, the reasons for taking selfies were significantly higher in Saudi nursing students than in Egyptian students regarding depression and sadness. As well, significantly higher in Egyptian than in Saudi nurse students was related to motivates that their selfies on social media often contain comments or answers, the relationship between the number of selfie-taking and gender was a statistically significant difference between the two genders in both Egyptian and Saudi groups with increasing taking selfie among Egyptian females and Saudi males.
A case report on aggressive giant cell tumor of greater trochanter: a divergent site
Authors: Singh Rohan Kumar , Parihar PratapSingh Hanuman , Mishra Gaurav Vedprakash , Dhande Rajasbala Pradeep , Patwa Prerna Anup 
Published: September 2021

Abstract
Background
Giant cell tumor is a tumor of benign nature which usually arises in the long bone, but it can also be seen at unusual sites. Only few cases have been reported so far regarding involvement of greater trochanter of the femur as it is a very divergent site for giant cell tumors; our case is one of them. Giant cell tumors are seen in 20–40 years of age in the metaepiphyseal regions of the long bones. If femur has to be involved, it is in the distal end usually.

Case presentation
We present a case of a 45-year-old female with chief complains of swelling and left hip pain since over a month. Magnetic resonance imaging was done where the location and extent of the tumor was found. What makes this case interesting is that on fine needle aspiration cytology the lesion showed multinucleated giant osteoclasts in the background of osseous matrix of spindle cells suggesting Giant cell tumor.

Conclusion
It is sometimes tricky to make a diagnosis of these lesions on imaging as the typical features may not be present, and hence, in such circumstances helping the clinicians with additional information like location, extent, margins is of utmost importance.
Headache in patients with systemic lupus erythematosus: characteristics, brain MRI patterns, and impact
Authors: Elolemy Gehan , Al Rashidi Abdulrahman , Youssry Doaa , Elziat Haytham , Baraka Eman 
Published: September 2021

Abstract
Background
The prevalence of primary headache in patients with systemic lupus erythematosus (SLE) varies widely and whether it should be attributed to neurological involvement is controversial. We aimed to investigate the prevalence and characteristics of headache in SLE patients, describe its association with disease-related variables and brain imaging, and explore its impact on life.

Results
The overall prevalence of headache was 54.4%, and migraine was the most common type among headache sufferers (48.4%). Headache severity (VAS) and impact (HIT-6) correlated with SLEDAI-2K (P = 0.019 and P < 0.001, respectively) as well as with each other (P = 0.006). Brain imaging abnormalities were found in 25.8%, with white-matter hyperintensities (WMH) being the most frequent pathology. Musculoskeletal manifestations, positive anti-phospholipid (aPL) antibodies, and SLEDAI score ≥ 13.5 were identified as predictors of headache.

Conclusion
Primary headache, especially migraine, is a common feature of patients with SLE, and its presence is associated with negative impact on quality of life. Musculoskeletal features, aPL positivity, and overall disease activity appear to predict primary headache in SLE.
Finite element analysis of the effect of microwave ablation on the liver, lung, kidney, and bone malignant tissues
Authors: Radmilović-Radjenović M. , Radjenović D. , Radjenović B. 
Published: September 2021

Abstract
Microwave ablation becomes a promising thermal modality for treating cancerous tumor cells in patients who are non-surgical candidates. To ensure the destruction of cancer cells with minimal damage to healthy tissue, the elevation of temperature and the evolution of the necrotic tissue need to be controlled. Besides experimental methods, computer modeling evolves into a powerful approach for improving the performance of the ablative treatment. This letter reports on the numerical studies of the microwave ablation effect on the liver, lung, kidney, and bone tumoral tissues. Calculations were performed by using the COMSOL Multiphysic based on a multi-component plasma fluid model. Simulation conditions include the microwave frequency of

, the input power of

, and taking into account the temperature dependence of dielectric properties of the tissue. The total loss power density, the temperature distribution, the fraction of the tissue damage, and the specific absorption rate have been determined. It was shown that the temperature distribution has an ellipsoidal shape reaching the maximal values required for effective cancer treatment but to avoid damaging healthy cells near the antenna slot. From the degree of tissue injury, the fraction of damage has been estimated revealing that the microwave ablation zones are concentrated around the tip and slot of the antenna. Also, the ablation of the tumor cells can be achieved over a long period without damaging healthy cells when small input power is used. The obtained results confirm that simulations can be very useful for predicting optimal conditions for the minimal damage of the healthy tissue during microwave ablation, and therefore may be implemented into treatment planning.
Reframing Suicide
Authors: Jafri Beenash 
Published: September 2021

AbstractWhat can narratives of suicide tell us about diasporic and Indigenous relationships to the white settler state? This article engages relational critique to examine trans/femme/bisexual South Asian Canadian filmmaker Vivek Shraya's short film I want to kill myself (2017) and queer Cree/Métis filmmaker Adam Garnet Jones's feature film Fire Song (2015). Both films challenge the spectacularity of suicide, effectively situating suicide on a continuum of “slow death.” However, the films also stage distinct relationships between suicide, community, and the state that emerge from diasporic and Native positionalities within a white settler society. Whereas Shraya's diasporic struggle with suicide is alleviated by forging community within settler spaces, Fire Song counters pathologizing depictions of reserve communities by emphasizing resurgent Indigenous practices and their refusal of settler logics.
Trans Sonorities in Grey Grant's “Drones for the In-Between Times”
Authors: Allphin Penrose M. 
Published: September 2021

Abstract
Composer intent has generally been downplayed by contemporary music analysts, often being regarded as an example of an intentional fallacy at best and misleading at worst. This analysis of Grey Grant's choral work posits that such a dismissal not only ignores the potential for an enhanced expressive context afforded by composers' own assessments, but it also contributes to the silencing of already marginalized voices, such as in the case of transgender composers. The author proposes a methodology that incorporates the voices of living composers while circumventing concerns about confirmation bias by building on the framework of music theory, queer musicology, and queer theory. The article demonstrates this theoretical framework using an interview of a transgender composer to supplement an analysis of their contemporary choral piece. By analyzing the work with the added context of the composer's statements about their own music, the author paints a more complete picture of the work, one that reinvests music analysis with the trans voice behind the composition.
The Work of Rape
Authors: Jaleel Rana M. 
Published: September 2021

In The Work of Rape Rana M. Jaleel argues that the redefinition of sexual violence within international law as a war crime, crime against humanity, and genocide owes a disturbing and unacknowledged debt to power and knowledge achieved from racial, imperial, and settler colonial domination. Prioritizing critiques of racial capitalism from women of color, Indigenous, queer, trans, and Global South perspectives, Jaleel reorients how violence is socially defined and distributed through legal definitions of rape. From Cold War conflicts in Latin America, the 1990s ethnic wars in Rwanda and Yugoslavia, and the War on Terror to ongoing debates about sexual assault on college campuses, Jaleel considers how legal and social iterations of rape and the terms that define it—consent, force, coercion—are unstable indexes and abstractions of social difference that mediate racial and colonial positionalities. Jaleel traces how post-Cold War orders of global security and governance simultaneously transform the meaning of sexualized violence, extend US empire, and disavow legacies of enslavement, Indigenous dispossession, and racialized violence within the United States.
Duke University Press Scholars of Color First Book Award recipient