bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastro-protective actions of Aloe barbadensis Miller mitigate ethanol-induced gastric injury in rats
Authors: Zhu Kai , Yang Xia , Yang Chun , Ye Xiaoxue , Zhang Hongxing 
Published: March 2021

Purpose: To investigate the gastroprotective effect of leaf extract of Aloe barbadensis on ethanolinduced gastric ulcer in rats.Methods: Healthy male Wistar rats (n = 30) weighing 180 - 220 g (mean weight = 200 ± 20 g) were randomly assigned to 6 groups (5 rats/group): control group, gastric ulcer group, two Aloe barbadensis extract groups (250 and 500 mg/kg), cimetidine group and indomethacin group. Gastric ulcer was induced via oral injection of absolute ethanol at a dose of 1 mL/kg after a 24-h fast. Gross evaluation, determination of gastric juice acidity and histological examination of gastric tissue were carried out.Results: Treatment of gastric ulcer rats with Aloe barbadensis extract significantly reduced ulcerated area (UA), ulcer index (UI), and acidity of gastric juice (p < 0.05). Injection of 1 % carrageenan into rat hind paw led to a time-dependent increase in paw volume which peaked 3 h after injection. However, the Aloe barbadensis extract significantly and dose-dependently reduced the volume of inflamed paw, and inhibited edema formation (p < 0.05). It also markedly reduced or completely eliminated edema and leucocyte infiltration. Moreover, treatment of gastric ulcer rats with Aloe barbadensis leaf extract led to significant and dose-dependent reduction in gastric tissue MDA level (p < 0.05). Histological examination of the gastric wall showed that control rats had severe injury in gastric mucosa,accompanied by edema and leucocytes infiltration, relative to rats pretreated with extract which showed marked gastric protection and inhibition of edema and leucocytes infiltration. Moreover, the extract treatment protected the gastric surface against ulceration as indicated by reduced lesions in the treated rat model.Conclusion: These results show that Aloe barbadensis mitigates ethanol-induced gastric injury in rats via inhibition of lipid peroxidation and inflammation. Thus, the extract has potentials for development into a therapeutic agent for the management of gastric ulcer.
Keywords: Aloe barbadensis, Gastric ulcer, Gastric mucosa, Inflammation, Lipid peroxidation
Quality comparison of traditional Chuanxiong produced in Dujiangyan City and Sichuan ProvinceC and Chuanxiong from other areas, based on analysis of volatile oil, total alkaloids and total ferulic acid contents
Authors: Chen Ling , Hou Jia , Deng Wei , Jiang Guihua 
Published: March 2021

Purpose: To compare the qualities of Chuanxiong from different production areas (authentic and traditional production areas in Dujiangyan, Sichuan Province) and other non-authentic production areas, as well as different germplasm sources, using a combination of methods.
Methods: A fingerprint spectrum of volatile oils was established, and the qualities of the chuanxiong samples were compared using gas chromatography (GC), while gas chromatography-mass spectrometry (GC -MS) was used to analyze the chemical compositions of the volatile oils.
Results: There were significant differences in the chemical compositions of volatile oils of Chuanxiong from different plants. Most of the qualities of Chuanxiong were higher after transplantation to the germplasm nursery at Dujiangyan, Sichuan. There was increase in the contents of total alkaloids and total ferulic acid in some chuanxiong transplanted to the germplasm nursery.
Conclusion: This is the first study that compares the quality of Chuanxiong from different producing areas using a combination of several methods. These methods are feasible and effective, and the results provide a reference for research on standardization and quality control of Chuanxiong.
Keywords: Chuanxiong, Volatile oil, Total alkaloids, Ferulic acid, Fingerprint, Dujiangyan City
Assessment of the impact of medPlan®, a medication reminder mobile application, in glaucoma patients in Benin City, Nigeria
Authors: Osahon Penaere T. , Mote Lisa A. , Ntaji Veronica I. 
Published: March 2021

Purpose: To assess the impact of medPlan®, a medication reminder mobile application in glaucoma patients in Benin City, Nigeria.Methods: In a randomized control trial with 2 months follow-up period, 200 patients receiving drug therapy for glaucoma were randomized into either into a control or study group. The study group comprised participants who made use of a medication reminder mobile application, medPlan®, while the control group consisted of those patients who did not use the application. Adherence to medication was measured for all the patients in both groups. Data was collected using a carefully designed questionnaire and statistically analyzed.Results: This study recorded 100 % response rate from the participants. In the study group, 56 % were very adherent while 18 % were moderately adherent, and 26 % were non-adherent respondents as against 45 % very adherent, 13 % moderately adherent and 42 % non-adherent respondents from the control group. In addition, 78 % of those in the study group agreed that there was improvement in their medication adherence since they started using the medication reminder application. This showed a significant positive impact of the medication reminder application (p = 0.0110) on adherence to medication.Conclusion: Medication adherence was improved in glaucoma patients who used medPlan®, a smartphone medication reminder application. This study lays a foundation for further research on medication reminder mobile applications.
Keywords: Glaucoma, Smartphone, Medication adherence, Impact, Medication reminder, medPlan®
CS nerve growth factor regulates sevoflurane anesthesiainduced nerve injury in nerve cells
Authors: Wang Naitian , Liu Duohui , Ning Xinyu , Li Zhanjun , Dong Lan 
Published: March 2021

Purpose: Sevoflurane is the most commonly used anesthetic agent for surgery. However, it is associated with deficiency in learning and memory abilities. The study was aimed at investigating the role of nerve growth factor (NGF) in sevoflurane anesthesia-induced nerve injury.Methods: RT-qPCR assay was applied to measure expressions of NGF, miR-98-5p and other factors related to apoptosis. CCK-8 assay was used for detecting cell viability while luciferase reporter assay was employed to measure binding condition between miR-98-5p and NGF. Expressions of proteins in PI3K/AKT/mTOR signaling pathway was measured with western blot.Results: Sevoflurane reduced cell viability of RGC-5 cells, promoted apoptosis and reduced the expression of NGF. In sevoflurane-induced RGC-5 cells, over-expression of NGF promoted cell viability with reduced apoptosis. Also, there was reduction in the protein expression of PI3K/AKT/mTOR signaling pathway by sevoflurane, while up-regulation of NGF promoted the expressions of these proteins. In the presence of PI3K inhibitor, reduction cell viability was reduced but apoptosis increased. Luciferase reporter assay detected MiR-98-5p as the target gene of NGF and its overexpression restored high cell viability in the over-expressed NGF. The rate of apoptosis and expressions of proteins was also restored with up-regulation of miR-98-5p.Conclusion: Sevoflurane caused damage to nerve cells, while over-expression of NGF reduced the injury through PI3K/AKT/mTOR signaling pathway and suppression of miR-98-5p.
Keywords: Nerve growth factor, Sevoflurane, Nerve injury, Anesthesia, miR-98-5p
Clinical and Epidemiological Features of Death with COVID-19 in Karnali Province of Nepal
Authors: BHATT LAXMAN DATT , Khadka Rabin , Thapa Kanchan , BC Udaya Bahadur , Wagle Chetan Nidhi 
Published: March 2021

Background: Coronavirus disease 2019 (COVID-19) has rapidly spread to many countries and increased mortality worldwide. Most deaths were either elderly or have underlying medical problems and even relatively young individuals have died from COVID-19. This study aimed to analyze the epidemiological and clinical characteristics of COVID-19 related deaths in Karnali Province, Nepal.
Materials and Methods: We studied COVID-19 deaths from 19 May 2020 to 25 December 2020. Information from all districts of Karnali Province were included in this study. Demographic characteristics and geographic distribution map of the death toll in each district over time was analyzed. Quantum GIS(QGIS) 3.16.2 version was used to plot the deaths on maps and IBM SPSS Statistics 25 to perform statistical analysis
Results: As of December 25, 2020, a total of 25 deaths were reported. Mean age of death was 52 (SD 20.99) years. Most of the deaths were distributed in age group of 50 years and above. Additionally, the male to female ratio was 5:2. A total of 56% of the deaths in Karnali were with underlying diseases and was more pronounced among males. Most of the cases were centralized in Surkhet district with highest death rate in Birendranagar municipality.
Conclusion: COVID-19 poses a greater threat to the elderly people with more devastating effects, particularly in the presence of underlying diseases. The geographical distributions show that the epidemic in the Surkhet district is more serious than that in the surrounding districts. Case investigation, Contract tracing and dedicated ICU ventilator service for critical cases are essential for response of Pandemic.
IMPLEMENTASI KOMUNIKASI KEPALA MADRASAH DALAM MENINGKATKAN MUTU GURU DI PONDOK PESANTREN DARUS SHOLIHIN KECAMATAN RANTAU UTARA KABUPATEN LABUHANBATU
Authors: Ahyar Syamsu Nahar, Candra Wijaya, 
Published: March 2021

<p><strong>Abstrak</strong>: Penelitian ini bertujuan untuk menganalisis: 1) pola Komunikasi Kepala Madrasah Tsanawiyah Pondok Pesantren Darus Sholihin Kecamatan Rantau Utara Kabupaten Labuhanbatu; 2) Upaya Kepala Madrasah dalam mengefektifkan komunikasi di lingkungan Madrasah Tsanawiyah Pondok Pesantren Darus Sholihin Kecamatan Rantau Utara Kabupaten Labuhanbatu; 3) Faktor pendukung dan penghambat apasajakah yang mempengaruhi proses Komunikasi Kepala Madrasah Tsanawiyah Pondok Pesantren Darus Sholihin Kecamatan Rantau Utara Kabupaten Labuhanbatu; 4) Kaitan Komunikasi Kepala madrasah dengan peningkatan mutu guru di Madrasah Tsanawiyah Pondok Pesantren Darus Sholihin Kecamatan Rantau Utara Kabupaten Labuhanbatu. Penelitian menggunakan pendekatan kualitatif. Teknik pengumpulan data penelitian berupa observasi, wawancara dan dokumentasi. Hasil penelitian ini mengungkapkan Tiga temuan yaitu: 1) Implementasi komunikasi yang dilakukan antara kepala madrasah dengan staf berjalan dengan lancar, bersuasana baik, serta komunikasi yang dilakukan dengan menggunakan komunikasi lisan dan tulisan. Dengan terjalinnya komunikasi tersebut antara kepala madrasah dengan staf untuk tercapainya tujuan yang sudah diharapkan dalam visi dan misi Pondok Pesantren Darus Sholihin Kecamatan Rantau Utara Kabupaten Labuhanbatu; 2) Implementasi komunikasi yang dilakukan antara kepala madrasah dengan guru berjalan dengan lancar, serta menggunakan komunikasi lisan dan tulisan. Terlihat pada rapat yang dilaksanakan pada setiap minggu yaitu pada hari Kamis, kepala madrasah dengan guru mempunyai kerja sama yang baik untuk menuntaskan kendala yang ada pada guru yang belum memenuhi standart pendidikan atau yang sudah, dan menangani kendala yang lain serta menyiapkan kewajiban sebagai seorang guru; 3) Implementasi komunikasi yang dilakukan antara kepala madrasah dengan pengawas berjalan dengan baik, dan dibangun melalui komunikasi langsung untuk dapat bekerja sama dalam menangani kendala yang dialami guru atau mengenai hal lainnya serta dapat mencapai tujuan yang terdapat dalam visi dan misi Pondok Pesantren Darus Sholihin Kecamatan Rantau Utara Kabupaten Labuhanbatu.</p><p><strong>Kata Kunci: </strong><strong>Implementasi, Komunikasi, Guru</strong><strong></strong></p>
STRATEGI MANAJEMEN KEPALA MADRASAH DALAM MENGEMBANGKAN SUMBER DAYA GURU DI MTS PERSIAPAN NEGERI HADUNDUNG KECAMATAN KOTA PINANG KABUPATEN LABUHANBATU SELATAN
Authors: Ali Ahmad Rapi Tanjung Candra Wijaya, Achyar Zein, 
Published: March 2021

<p><strong>Abstrak</strong>: Penelitian ini bertujuan untuk menganalisis: 1) Strategi perencanaan kepala madrasah dalam mengembangkan sumber daya guru di MTs Persiapan Negeri Hadundung Kecamatan Kota Pinang Kab. Labuhanbatu Selatan. 2) Strategi pelaksanaan kepala madrasah dalam mengembangkan sumber daya guru di MTs Persiapan Negeri Hadundung Kecamatan Kota Pinang Kab. Labuhanbatu Selatan. 3) Strategi pengawasan kepala madrasah dalam mengembangkan sumber daya guru di MTs Persiapan Negeri Hadundung Kecamatan Kota Pinang Kab. Labuhanbatu Selatan. Penelitian menggunakan pendekatan kualitatif naturalistik. Teknik pengumpulan data penelitian berupa observasi, wawancara dan dokumentasi. Hasil penelitian ini mengungkapkan Tiga temuan yaitu: Hasil temuan peneltian adalah: 1) Strategi perencanaan kepala madrasah dalam mengembangkan sumberdaya guru di MTs Persiapan Negeri Hadundung Kecamatan Kota Pinang Kab. Labuhanbatu Selatan seperti untuk mengadakan program pelatihan untuk mengembangkan sumber daya guru untuk mewujudkan kualitas kerja guru yang profesional. 2) Strategi pelaksanaan kepala madsarasah dalam mengembangkan sumber daya guru bawasannya kepala sekolah melakukan rapat MGMP (Musyawarah Guru Mata Pelajaran) kepada seluruh guru yang ada di madrasah tersebut. Kemudian kepala sekolah mengirimkan beberapa guru-guru dalam setiap tiga bulan sekali mengikuti pelatihan, pembina seperti <em>worshop</em>,diklat serta pembuatan RPP, silabus dan kurikulum 2013. Untuk mengembangkan dan pembinaan para guru-guru tersebut. 3) Strategi pengawasan kepala madrasah dalam mengembangkan sumber daya guru di MTs Persiapan Negeri Hadundung Kecamatan Kota Pinang Kab. Labuhanbatu Selatan bahwasannya kepala sekolah dengan melakukan mengobservasi kelas dan melihat kondisi kelas dan kemudian kepala sekolah melakukan komunikasi dengan baik dengan para guru-guru dan kepala sekolah memberi pengembangan guru berupa pelatihan untuk kesejatraan guru.</p><p><strong>Kata Kunci: </strong>Strategi, Manajemen, dan Guru<strong></strong></p><p><strong> </strong></p>
KEMAMPUAN GURU BERSERTIFIKASI DALAM MENGEMBANGKAN TUGAS POKOK GURU PENDIDIKAN AGAMA ISLAM DI SEKOLAH MENENGAH ATAS NEGERI 2 RANTAU SELATAN
Authors: Khairul Achyar Zein, Syamsu Nahar, 
Published: March 2021

<p><strong>Abstrak</strong>: Penelitian ini bertujuan untuk menganalisis: 1) Perencanaan guru yang telah sertifikasi dalam menyusun strategi pembelejaran, metode pembelajaran dan materi pembelajaran SMA Negeri 2 Rantau Selatan Provinsi Sumatera Utara. 2) Pelaksanaan atau mengemplementasikan program pembelajaran yang dilakukan oleh guru yang telah sertifikasi di SMA Negeri 2 Rantau Selatan Provinsi Sumatera Utara. 3) Pengawasan atas kinerja yang dilakukan oleh guru pasca sertifikasi serta siapa saja yang terlibat dalam pengawasan tersebut di dalam meningkatkan kualitas pembelajaran di SMA Negeri 2 Rantau Selatan Provinsi Sumatera Utara. Penelitian menggunakan pendekatan kualitatif naturalistik. Teknik pengumpulan data penelitian berupa observasi, wawancara dan dokumentasi. Hasil penelitian ini mengungkapkan Tiga temuan yaitu: Hasil temuan peneltian adalah: 1) Perencanaan guru yang telah sertifikasi dalam menyusun strategi pembelajaran, metode pembelajarn dan materi pembelajaran ialah sebelum guru memulai pembelajaran di dalam kelas guru terlebih dahulu mempersiapkan instrumen-instrumen yang akan di gunakan dalam proses pembelajaran. 2) Implementasi program pembelajaran yang dilakukan oleh guru yang telah sertifikasi berjalan dengan baik. Terlihat jelas bahwa persiapan yang dibuat oleh guru mata pelajaran terutama pada guru yang telah sertifikasi sebelum proses pembelajaran di mulai. Pelaksanaan yang di lakukan guru didalam kelas sesuai dengan apa yang disusun sebelumnya, sehingga proses belajar mengajar tercapai dengan efektif dan efesien. 3) Pengawasan atas kinerja yang di lakukan terhadap guru pasca sertifikasi serta siapa saja yang terlibat dalam pengawasan dalam meningkatkan kualitas pembelajaran yang di lakukan terhadap sangat berpengaruh besar terhadap kinerja guru. </p><p> </p><strong>Kata Kunci: </strong>Kemampuan, dan Guru
PERAN KEPALA SEKOLAH DALAM MENINGKATKAN PROFESIONALITAS GURU DI SEKOLAH MENENGAH PERTAMA NEGERI 1 HALONGONAN TIMUR KABUPATEN PADANG LAWAS UTARA
Authors: Khairul Anwar Syamsu Nahar,  Edi Saputra, 
Published: March 2021

<p><strong>Abstrak</strong>: Penelitian ini bertujuan untuk menganalisis: 1) Bagaimana perencanaan kepala sekolah dalam mengembangkan profesionalitas guru di SMP Negeri 1 Halongonan Timur Kabupaten Padang Lawas Utara, 2) Bagaimana pelaksanaan supervise kepala sekolah dalam mengembangkan profesionalitas guru di SMP Negeri 1 Halongonan Timur Kabupaten Padang Lawas Utara, 3) Bagaimana tindakan kepala sekolah dalam memotivasi guru di SMP Negeri 1 Halongonan Timur Kabupaten Padang Lawas Utara. Penelitian menggunakan pendekatan kualitatif. Teknik pengumpulan data penelitian berupa observasi, wawancara dan dokumentasi. Hasil penelitian ini adalah perencanaan yang dilakukan kepala sekolah adalah membuat kreteria penerimaan anggota baru, membuat program kerja guru per triwulan, menghemat dana sekolah. Pengawasan yang dilakukan adalah pengawasan model formatif dan sumatif yaitu secara berkala dalam setiap minggu masuk langsung ke dalam kelas memperhatikan cara guru mengajar. Motivasi ekstrinsik atau motivasi yang dilakukan oleh kepala sekolah dalam memotivasi gurunya yaitu dengan cara memberikan pujian, selalu bersikap menghormati guru, mendengarkan keluhan guru dan menindaklanjuti apa yang menjadi keluhan guru serta pelatihan di bidang IT. Sedangkan motivasi interinsik yaitu pada saat ada pelatihan guru tidak dapat hadir mengikuti pelatihan tersebut tetapi karena guru tersebut ingin memperoleh ilmu, maka guru itu belajar kepada rekannya agar guru tersebut dapat terus meningkatkan kemampunya. </p><p><strong>Kata Kunci: </strong><strong>Peran dan Profesionalitas</strong></p>
O Olhar – Fazer Interdisciplinar no Atendimento às Vítimas de Violência Doméstica no âmbito Policial: Estudo Preliminar
Authors: Hermann Michael 
Published: March 2021

Este trabalho foi desenvolvido durante uma experiência profissional dentro de uma delegacia de polícia – instituição esta que, no final da década de 90, passou por várias reformas não só dentro do seu aparato administrativo, mas na sua concepção de como a mesma vê a violência e suas causas. Os novos profissionais policiais capacitados e preparados vêm com esta concepção, porém, ainda maculada com as velhas práticas repressoras e burocráticas da própria instituição. Com essa mudança, vem à inclusão dos profissionais não policiais, constituídos em sua maioria por assistentes sociais, psicólogos e pedagogos, que primeiramente não são incorporados nos quadros da polícia estadual, mas fazem parte de um projeto que gerou tais modificações dentro do aparato da segurança pública no Estado do Rio de Janeiro. Tal projeto se denomina Programa Delegacia Legal, em que o grupo gestor do mesmo não quer que o projeto seja passageiro, fruto de um momento conjuntural e político, mas quer que ele faça parte do organograma que constituí o sistema de segurança pública de fato. Dentro da “delegacia legal” há a constituição de uma equipe de profissionais – policiais ou não – prontos para atender a população que necessita de demandas que ultrapassam a natureza criminal. As demandas que fogem ao objeto do inquérito policial são ainda desprezadas por muitos profissionais policiais, e gera conflitos com os demais profissionais não policiais – que são capacitados a atenderem tais demandas. Este trabalho expõe as formas de como estas equipes são constituídas dentro de uma delegacia de polícia, e mostra como é possível formar uma equipe – constituída de profissionais policiais e não policiais – que trabalhe de uma forma interdisciplinar, atendendo assim a todas as demandas e encaminhamentos posteriores, mesmo com todas as dificuldades institucionais e com a correlação de forças presente.
Avaliação Do Uso De Agente Compatibilizante No Comportamento Mecânico Dos Compósitos PEBD Reforçados Com Fibras De Coco Verde
Authors: Oliveira Taysa Ávila , Teixeira Alison , Mulinari Daniella Regina , Goulart Shane Aparecida Soares 
Published: March 2021

Nesta pesquisa, amostras de polietileno de baixa densidade (PEBD) e compósitos de fibra de coco verde reforçados em polietileno de baixa densidade, não compatibilizados e compatibilizados, foram avaliadas quanto às propriedades mecânicas (tração). As superfícies fraturadas dos compósitos ensaiados foram analisadas. Os resultados obtidos revelaram que os compósitos de fibras de coco reforçados com polietileno de baixa densidade compatibilizados apresentaram melhores propriedades mecânicas quando comparados aos compósitos não compatibilizados.
Karatê e agressividade: possíveis relações
Authors: Severino Cláudio Delunardo , Barbosa Andressa De Oliveira 
Published: March 2021

O presente estudo objetiva analisar possíveis relações entre a prática do Karatê e o comportamento, algumas vezes, agressivo por parte de seus adeptos. Para tal, investigaram-se as linhas teóricas do Karatê, seu histórico, ensino, conceitos e as suas abordagens gerais e, sendo assim, buscou-se compreender como os professores de Karatê trabalham com seus alunos a questão da agressividade, bem como as suas consequências. Além disso, procurou-se estabelecer uma maior compreensão acerca da agressividade, bem como suas principais características e conceitos específicos. A metodologia empregada tratou-se de uma pesquisa exploratória, discursiva, de cunho bibliográfico, além de pesquisa de campo para coleta de dados. O instrumento para a coleta de dados foi um questionário contendo perguntas acerca do desenvolvimento do Karatê, por parte dos professores, e também a relação destes com a temática da agressividade, através do qual delineamos a pesquisa a fim de obter o subsídio necessário para a análise proposta. Os participantes da pesquisa tiveram as suas respostas analisadas para que as mesmas pudessem ser generalizadas e projetadas, identificando-se a melhor forma de aproveitar as informações. Considerando que existem possíveis relações entre a prática do Karatê por crianças e adolescentes e o comportamento agressivo, eventualmente, apresentado pelos mesmos. A elaboração deste estudo justifica-se pela relevância de investigações relacionadas às linhas teóricas do Karatê. Consideramos também os aspectos culturais associados à agressividade e à contribuição que os seus resultados possam vir a apresentar aos profissionais ligados ao processo de ensino-aprendizagem desta arte marcial. Alguns professores consideram que condutas agressivas podem contribuir para o rendimento do aluno, e é esse equívoco que faz com que o indivíduo não seja capaz de lidar com o insucesso, ocasionando algumas vezes ações agressivas e até mesmo a violência. Sendo assim, notamos que podem existir relações entre a prática do Karatê e a agressividade, mas que não é o esporte o causador direto desse comportamento agressivo.