bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study Protocol: A Hybrid Delivery of Home-Based Cluster Set Resistance Training for Individuals Previously Treated for Lung Cancer
Authors: Fairman Ciaran M , Owens Otis L , Kendall Kristina L , Steele James , Latella C , Jones Morgan T , Marcotte Lauren , Peddle-McIntyre Carolyn J , McDonnell Karen K 
Published: October 2021

Abstract
Background: Symptom burden remains a critical concern for individuals with non-small cell lung cancer (NSCLC) following the completion of treatment. The most common symptom clusters, dyspnea (shortness of breath) and fatigue,can contribute to physical decline, reductions in quality of life, and a higher risk of comorbidities and mortality. Dyspnea is a primary limiter of exercise capacity in individuals with lung cancer, resulting in exercise avoidance and an accelerated physical decline. As such, designing resistance training with cluster sets to mitigate symptoms of dyspnea and fatigue may result in improved exercise tolerance. Thus, maintainingthe exercise stimulus via cluster sets, combined with improved tolerance of the exercise, could result in maintenance of physical function and quality of life. The purpose of this study is to investigate the feasibility and preliminary efficacy of a hybrid-delivery home-based cluster-set resistance training program in individuals with NSCLC. Methods: Individuals with NSCLC (n=15), within 12-months of completion of treatment will be recruited to participate in this single arm feasibility trial. Participants will complete 8-weeks of home-based resistance training designed to minimizedyspnea and fatigue. The hybrid-delivery of the program will include supervised sessions in the participants’ home, and virtual supervision via video conferencing. The primary outcome of feasibility will be quantifiedby recruitment rates, retention, acceptability, and intervention fidelity. Exploratory outcomes (dyspnea, fatigue, quality of life, physical function, and body composition) will be assessed pre- and post- intervention. Discussion: This study will provide important data on the feasibility of delivering this intervention and inform procedures for a future randomized controlled trial. Trial Registration: Record not yet public
Inhibition of TGF-β Signaling Suppresses Th17 Differentiation and Promotes Treg Numbers but does not Reduces Experimental Arthritis
Authors: Aarts Joyce , Caam Arjan , Marijnissen Renoud M. , Helsen Monique M. , Walgreen Birgitte , Vitters Elly L. , Loo Fons A. , Lent Peter L. , Koenders Marije I , Kraan Peter van der 
Published: October 2021

Abstract
ObjectivesTGF-β is an important growth factor to promote the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). The potential of TGF-β as therapeutic target in T cell-mediated diseases like rheumatoid arthritis (RA) is unclear. We investigated the effect of TGF-β inhibition on murine Th17 differentiation in vitro, on human RA synovial explants ex vivo, and on the development of experimental arthritis in vivo. MethodsMurine splenocytes were differentiated into Th17 cells, and the effect of the TGF-βRI inhibitor SB-505124 was studied. Synovial biopsies were cultured in the presence or absence of SB-505124. Experimental arthritis was induced in C57Bl6 mice and treated daily with SB-505124. FACS analysis was performed to measure different T cell subsets. Histological sections were analysed to determine joint inflammation and destruction.ResultsSB-505124 potently reduced murine Th17 differentiation by decreasing Il7a and Rorc gene expression and IL-17 protein production. SB-505124 significantly suppressed IL-6 production by synovial explants. In vivo, SB-505124 reduced Th17 levels, while increased levels of Tregs were observed. Despite this skewed Th17/Treg balance, SB-505124 treatment did not result in suppression of joint inflammation and destruction.ConclusionsBlocking TGF-β signalling suppresses Th17 differentiation and improves the Th17/Treg balance. However, SB-505124 treatment does not suppress experimental arthritis.
An Analysis About The Impact of Monetary Policy Shocks On The Flow of Funds Account: The Case of Iran
Authors: Barzani Mohammad Vaez , Ebrahimi Meymanat , Torki Leila , Heydari Hassan 
Published: October 2021

Abstract
The flow of funds account provides information on various economic sectors’ financial transactions. The present study has investigated the impact of monetary shocks on the dynamics of lending and borrowing of various economic sectors such as households, non-financial enterprises, the banks, the Central Bank of Iran (CBI), the government, and the foreign sector as well as the changes in financial assets and liabilities of mentioned sectors. An accurate analyzing in this regard could provide helpful guidance in making the appropriate policies for influencing macroeconomic variables. For this purpose, a FAVAR model was employed using data from 1973-2017. It was concluded that monetary shocks increased both the acquisition of new financial assets and the issuance of new liabilities of various national economic sectors and the banks were net borrowers from other economic sectors while other sectors – except the non-financial enterprises and the government that response with a delay– were net lenders in the first year. However, all national economic sectors turned into lenders and the foreign sector had become the borrower after the first year is passed. The reason for this appears to be the difference between domestic and foreign interest rate. Net capital outflow occurs for two years significantly.
Characterization of rice farming systems, production constraints and determinants of adoption of improved varieties by smallholder farmers of the Republic of Benin
Authors: LOKO Yêyinou Laura Estelle , GBEMAVO Charlemagne D.S.J. , DJEDATIN Gustave , EWEDJE Eben-Ezer , OROBIYI Azize , TOFFA Joelle , TCHAKPA Cyrille , SEDAH Paulin , SABOT François 
Published: October 2021

Abstract
The Republic of Benin has the potential to reduce its heavy dependence on rice imports to meet the needs of its population. For that, the identification of technological and policy interventions allowing to improve the performance of Beninese rice systems is necessary. This study therefore characterized the Beninese rice farming systems and identified the production constraints in the country's different rice-growing areas, and determinants of the adoption of improved varieties by farmers. Four hundred eighteen rice farm households were surveyed across 39 villages using participatory research tools and methods. An hierarchical cluster analysis were used to classify the surveyed farm households into rice farming systems based on household socio-demographic characteristics, farm resources, farming practices and access to agricultural extension services. The cluster analysis revealed four typologies of rice farming systems differentiated by 8 variables. These are, the semi-intensive rice farming system (cluster 1), subsistence rice farming (cluster 2), integrated rice–livestock farming system (cluster 3), and intensive rice farming system (cluster 4). The integrated rice–livestock farming system was the dominant type practiced in the northern Benin, while, it is the intensive rice farming system in the south. Fifteen production constraints across rice-growing areas were recorded, with the lack of agricultural machinery and credits as the most important. The land ownership, risk aversion, production of off-season rice, and contact of farmers with non-governmental organizations positively influenced the adoption of improved rice varieties. Our results suggest that initiatives to boost rice production in Republic of Benin should prioritize the establishment of formal agricultural credit and mechanization option policies. We recommend training of rice farmers on modern production techniques. To increase adoption of improved rice varieties, agricultural extension services should target landowners’ farmers practising off-season rice production, and having in addition to agricultural income, other income from various activities.
Natural Radionuclide (Gamma and Alpha Emitters) in Grain Samples Collected from Kerbala Governorate, Iraq
Authors: Hamzah Zahraa Saad , Hashim Abdalsattar , Abojassim Ali 
Published: October 2021

Abstract
The aim of this research is to detect nature radioactivity for gamma emitters (specific activity 238U, 232Th, and 40K) using NaI(Tl) detectors and alpha emitters (concentrations of 222Rn, 226Ra, and 238U) using CR-39 detectors in selected samples of grain that are collected from Kerbala governorate. Also, annual effective dose and some radiological parameters due to gamma and alpha emitters to assess the health risk were calculated. Results have been shown that the average value of specific activities for 238U, 232Th and 40K were 6.61±0.91 Bq/kg, 3.07±0.22 Bq/kg and 227.59±32.34 Bq/kg respectively, while the average value of alpha emitters concentrations for 222Rn, 226Ra, and 238U were 3.99±1.13 Bq/m3, 4.69±1.28 mBq/kg and 0.072±0.019 Bq/kg respectively. The results of average total of annual effective dose associated with the exposure due to gamma and alpha emitted from ingestion grain samples in the present study were 0.139±0.013 mSv/y and 0.172±0.047 µSv/y, respectively. The results of natural Radionuclide and radiological parameter hazard based on gamma and alpha emitters from grain samples were discovered to be within the world acceptable levels. Finally, natural radioactivity from the grain samples that collected from Kerbala governorate were safety for the human consumption.
Comparison of Femoral Neck System Versus Dynamic Hip System Blade for the Treatment of Femoral Neck Fracture in Young Patients: A Retrospective Study
Authors: Ge Zilu , Xiong Wei , Tang Yunfeng , Wang Dong , Fang Qian , Wang Limin , Zhang Zhen , Wang Guanglin 
Published: October 2021

Abstract
Background: Femoral neck fracture is a common fracture in orthopedic practice. This study aimed to compare the clinical outcomes between the femoral neck system and dynamic hip system blade for the treatment of femoral neck fracture in young patients.Methods: This retrospective study included 43 and 52 patients who underwent treatment for femoral neck fracture with the femoral neck system and dynamic hip system blade, respectively, between August 2019 and February 2020. Operative indexes, including operation duration, blood loss, incision length, postoperative complications (femoral neck shortening, non-union, screw pull-out, femoral head necrosis), and Harris scale scores (preoperative and postoperative) were recorded and analyzed. Results: Compared to that with the dynamic hip system blade, the femoral neck system showed significantly less operation duration (femoral neck system vs dynamic hip system blade: 47.09±9.19 vs 52.90±9.64, P=0.004), less blood loss (48.53±10.69 vs 65.31±17.91, P<0.001), and shorter incision length (4.04±0.43 vs 4.93±0.53, P<0.001), but more expensive hospitalization charge (51224.14±2289.81 vs 41468.73±2431.05, P<0.001). Femoral neck shortening was significantly lower with the femoral neck system than with the dynamic hip system blade (3.93±2.40, n=39 vs 5.22±2.89, n=44, P=0.031). No statistical differences were observed between the two groups in nonunion, screw pull-out, and femoral head necrosis. In addition, the latest follow-up Harris scale score was significantly higher with the femoral neck system than with the dynamic hip system blade (92.3±4.5 vs 89. 9±4.9, P=0.015).Conclusion: The femoral neck system results in less trauma, less femoral neck shortening, and better hip joint function than the dynamic hip system blade for the treatment of femoral neck fracture in young patients.
Design And Implementation of A Web-Based Self-Care Application For Patients With Kidney Stone Treated With Extracorporeal Shock Wave Lithotripsy
Authors: Maserat Elham , Mohammadzadeh Zeinab , Asadi-Shishegaran Rogayeh 
Published: October 2021

Abstract
Background: Kidney stone is the third most common, painful and costly problem among diseases of the urinary system after urinary tract infections and prostate diseases. The prevalence of kidney stones reduces the patient's quality of life and imposes high costs on patients and health care system. Extracorporeal shock wave lithotripsy is a safe procedure to treat urinary stones. Appropriate strategies like self-care programs can effectively reduce the prevalence and recurrence of this disease, and increase quality of life, save costs, and prevent disease by increasing patient participation. The aim of this study is to design and implement a web-based self-care application for patients with kidney stones undergoing extracorporeal shock wave lithotripsy.Methods: This paper is an applied study and was performed in Sabalan Hospital in Ardabil affiliated to the Social Security Organization of Iran in three stages including needs assessment, design and evaluation. For needs assessment and application design, a questionnaire was designed by searching library resources. The questionnaire was completed by clinical specialists and specialists in health information management and information technology. Then, based on the approved information elements and capabilities, a web-based self-care application was designed. The usability of the designed program was evaluated with the participation of 20 users.Results: The results of the survey showed that the experts confirmed all identified items and components, and considered them necessary. Users rated the usability of the self-care program at a good level with an average score of 7.9 out of 9.Conclusions: The usability of the self-care application was satisfactory to users in various areas of overall application performance, screen, terminology and information, learning and general impressions.
An Investigation To Achieve a Good Surface Integrity in WEDM of Ti-6242 Super Alloy
Authors: Ezeddini Sonia , Rajhi Wajdi , Boujelbene Mohamed , Bayraktar Emin , Salem Sahbi Ben 
Published: October 2021

Abstract
Ti-6242 is a super alloy which exhibits the best creep resistance among available titanium alloys and is widely used in the manufacture by WEDM of aircraft engine turbomachinery components. However, the final quality of wire EDMed surface is a great challenge as it is affected by various factors that need optimization for surface integrity and machine efficiency improvement. The aim of this study is to investigate the effect of a set of cutting process parameters such as pulse on time (Ton), servo voltage (U), feed rate (S) and flushing pressure (p) on surface roughness (SR) when machining Ti-6242 super alloy by WEDM process using a brass tool electrode and deionized water as a dielectric fluid. WEDM experiments were conducted, and SR (Ra) measurement was carried out using a 3D optical surface roughness-meter (3D–SurfaScan). As a tool to optimize cutting parameters for SR improvement, Taguchi's signal‐to‐noise ratio (S/N) approach was applied using L9 (3^4) orthogonal array and Lower-The-Better (LTB) criteria. Substantially, the findings from current investigation suggest the application of the values 0.9 µs, 100V, 29 mm/min, and 60 bar for Ton, U, S and p cutting parameters, respectively, for producing a good surface finish quality. Percent contributions of the machining parameters on SR (Ra) assessed based on ANOVA analysis are 62.94%, 20.84%, 11.46% and 4.74% for U, S, Ton and p, respectively. Subsequently, accurate predictive model for SR (Ra) is established based on response surface analysis (RSA). The contour plots for SR (Ra) indicate that when flushing pressure p converges to a critical value (80 bar), a poor-quality surface finish is highly expected with the excessive increase in U and S. Electron microscope scanning (SEM) observations have been performed on machined surface for a wide range of cutting parameters to characterize wire EDMed surface of Ti-6242. SEM micrographs indicate that the machined surface acquires a foamy structure and shows white layer and machining-induced damage that the characteristics are highly dependent on cutting parameters. At high servo-voltage, the decrease in pulse on time Ton and feed rate S results in a large decrease in overall machining-induced surface damage. Moreover, for high servo-voltage and feed rate levels, it has been observed that pulse on time could play a role of controlling the surface microcracks density. In fact, the use of a low pulse duration of cut combined with high servo-voltage and feed rate has been shown to inhibit surface microcracks formation giving the material surface a better resistance to cracking than at high pulse duration.
Molecular delineation of de novo Small Supernumerary Marker Chromosomes in prenatal diagnosis, a retrospective study
Authors: Hu Shuang , Kong Xiangdong 
Published: October 2021

Abstract
Objective To define the genotype-phenotype correlation of small supernumerary marker chromosomes (sSMC) and conduct precise genetic counseling.Methods We retrospectively searched and reviewed the de novo sSMC cases detected during prenatal diagnosis in The First Affiliated Hospital of Zhengzhou University. Chromosome karyotypes of 20314 cases of amniotic fluid from pregnant women were performed. For 17 samples with de novo sSMC, 11 of them were subjected to single nucleotide polymorphism (SNP) array or low-coverage massively parallel copy number variation sequencing (CNV-seq) analysis. Results Among the 11 sSMC cases, two sSMC were derived from chromosome 9, four sSMC were derived from chromosome 12, 18, 22 and X , separately. For the remaining 5 cases, they were not identified by SNP array or CNV-seq because they lacked euchromatin or had low proportion mosaicism. Four of them with the karyotype of 47,XN,+mar presented normal molecular cytogenetic results (seq[hg19] 46,XN ) , the left one with the karyotype of 46,XN,+mar was Turner syndrome (seq[hg19] 45,XO). Five sSMC samples were mosaics of all these 17 cases. Conclusion Considering the variable origins of sSMC, further genetics testing of sSMC should be performed by SNP array or CNV-seq. The detailed molecular characterization would allow precise genetic counseling for prenatal diagnosis.
Deep Learning-Based Quantitative Analyses of Spontaneous Movements and Their Association With Early Neurological Development in Preterm Infants
Authors: Shin Hyun Iee , Shin Hyung-Ik , Bang Moon Suk , Kim Don-Kyu , Shin Seung Han , Kim Ee-Kyung , Kim Yoo-Jin , Lee Eun Sun , Park Seul Gi , Lee Woo Hyung 
Published: October 2021

Abstract
This study aimed to develop quantitative assessments of spontaneous movements in high-risk preterm infants based on a deep learning algorithm. Video images of spontaneous movements were recorded in very preterm infants at the term-equivalent age. The Hammersmith Infant Neurological Examination (HINE) was performed in infants at 4 months of corrected age. Joint positional data were extracted using a pretrained pose-estimation model. Similarity and complexity indices of joint angle and angular velocity were compared between the infants with HINE <60 and ≥60. Video images of spontaneous movements were recorded in 65 preterm infants at term-equivalent age. Complexity indices of joint angles and angular velocities differed between the infants with HINE<60 and ≥60 and correlated positively with HINE scores in most of the joints at the upper and lower extremities (p<0.05). Similarity indices between each joint angle or joint angular velocity did not differ between the two groups in most of the joints at the upper and lower extremities. Quantitative assessments of spontaneous movements in preterm infants are feasible using a deep learning algorithm. The results indicated that complexity indices of joint movements at both the upper and lower extremities can be potential candidates for detecting cerebral palsy in preterm infants.
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites
Authors: Williams Thomas L. , Strachan Gregory , Macrae Robyn G.C. , Kuc Rhoda E. , Nyimanu Duuamene , Paterson Anna L. , Sinha Sanjay , Maguire Janet J. , Davenport Anthony P. 
Published: October 2021

Abstract
ACE2 is a membrane protein that regulates the cardiovascular system. Additionally, ACE2 acts as a receptor for host cell infection by human coronaviruses, including SARS-CoV-2 that emerged as the cause of the on-going COVID-19 pandemic and has brought unprecedented burden to economy and health. ACE2 binds the spike protein of SARS-CoV-2 with high affinity and shows little variation in amino acid sequence meaning natural resistance is rare. The discovery of a novel short ACE2 isoform (deltaACE2) provides evidence for inter-individual differences in SARS-CoV-2 susceptibility and severity, and likelihood of developing subsequent ‘Long COVID’. Critically, deltaACE2 loses SARS-CoV-2 spike protein binding sites in the extracellular domain, and is predicted to confer reduced susceptibility to viral infection. We aimed to assess the differential expression of full-length ACE2 versus deltaACE2 in a panel of human tissues (kidney, heart, lung, and liver) that are implicated in COVID-19, and confirm ACE2 protein in these tissues. Using dual antibody staining, we show that deltaACE2 localises, and is enriched, in lung airway epithelia and bile duct epithelia in the liver. Finally, we also confirm that a fluorescently tagged SARS-CoV-2 spike protein monomer shows low binding at lung and bile duct epithelia where dACE2 is enriched.
S100A8 Enhances IL-1β Production from Nasal Epithelial Cells in Eosinophilic Chronic Rhinosinusitis
Authors: Nakatani Ayaka , Tsuda Takeshi , Maeda Yohei , Hayama Masaki , Okuzaki Daisuke , Obata Sho , Kishikawa Toshihiro , Takeda Kazuya , Inohara Hidenori 
Published: October 2021

Abstract

Chronic rhinosinusitis is classified into eosinophilic chronic rhinosinusitis (ECRS) and non-eosinophilic chronic rhinosinusitis (NECRS). ECRS is a refractory allergic disease involving a variety of immune and epithelial cells. S100A8 is a damage-associated molecular pattern that is closely related to allergic inflammation. However, the pathological implications of S100A8 in ECRS have not been clarified. We evaluated the role of S100A8 in the pathogenesis of ECRS. Gene expression profiles of nasal polyps obtained from patients with ECRS or NECRS were evaluated using RNA sequencing. S100A8 was identified as a significantly upregulated gene in nasal polyps associated with ECRS. Immunohistochemistry consistently revealed intense S100A8 staining in nasal polyps from patients with ECRS. Human nasal epithelial cells expressed the receptor for advanced glycation end products and Toll-like receptor 4. Recombinant S100A8 protein induced interleukin-1β secretion in human nasal epithelial cells. Our data demonstrate that S100A8 results in production of interleukin-1β in the nasal epithelium, which may be involved in the pathogenesis of ECRS.