bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boronate-Based Fluorescent Probes as a Prominent Tool for H2O2
Sensing and Recognition
Authors: Wang Ling , Hou Xuben , Fang Hao , Yang Xinying 
Published: September 2021

Abstract:
Given the crucial association of hydrogen peroxide with a wide range of human
diseases, this compound has currently earned the reputation of being a popular biomolecular
target. Although various analytical methods have attracted our attention, fluorescent
probes have been used as prominent tools to determine H2O2 to reflect the physiological
and pathological conditions of biological systems. The sensitive responsive part
of these probes is the boronate ester and boronic acid groups, which are important reporters
for H2O2 recognition. In this review, we summarize boronate ester/boronic acid
group-based fluorescent probes for H2O2 reported from 2012 to 2020, and we have generally
classified the fluorophores into six categories to exhaustively elaborate the design
strategy and comprehensive systematic performance. We hope that this review will inspire
the exploration of new fluorescent probes based on boronate ester/boronic acid
groups for the detection of H2O2 and other relevant analytes.
In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity
Authors: Wang Liyan , Zhao Tingting , Wang Yunxiang , Hu Banglian , Tao Jianfei , Ke Jinshan , Wei Tingfei , Ge Guangbo , Meng Qiang , Wang Changyuan , Liu Qi , Sun Huijun , Wu Jingjing , Chen Yanwei 
Published: September 2021

Background:
Imatinib, sunitinib, and gefitinib are the three most common tyrosine kinase inhibitors
(TKIs). However, their quantitative drug-drug interaction potentials In vivo and the relationship between their structure
and inhibitory activity remain unknown.

Objective:
This study aimed to investigate the potential drug-drug interaction risk of three TKIs based on CYP3A.

Methods:
6β-Hydroxylated testosterone formation was selected to probe the CYP3A activity in human liver microsomes.
A molecular docking simulation was performed to explore the potential structural alerts.

Results:
Imatinib exhibited the strongest inhibitory effect towards CYP3A, while the inhibitory potential of gefitinib
and sunitinib were comparable to each other but weaker than imatinib. IC50 shift assays demonstrated that the inhibitory
potential of all three TKIs was significantly increased after a 30-min preincubation with NADPH. The KI and
Kinact values of imatinib, sunitinib, and gefitinib were 3.75 μM and 0.055 min-1, 1.96 μM and 0.037 min-1, and 9.94
μM and 0.031 min-1, respectively. IVIVE results showed that there was a 1.3- to 43.1-fold increase in the AUC of
CYP3A-metabolizing drugs in the presence of the TKIs.

Conclusion:
All three TKIs exhibited a typical irreversible inhibitory effect towards CYP3A. The presence of more N-heterocycles and the resulting better binding confirmation of imatinib may have been responsible for its stronger inhibitory effect than sunitinib and gefitinib. Therefore, caution should be taken when CYP3A-metabolizing drugs are co-administrated with imatinib, sunitinib, or gefitinib.
Amelioration of Cisplatin-induced Renal Inflammation by Recombinant Human Golimumab in Mice
Authors: Pavitrakar Vishal , Mody Rustom , Ravindran Selvan 
Published: September 2021

Background:
One of the most commonly used anti-cancer agents, Cisplatin (CDDP) often causes nephrotoxicity by eliciting inflammation and oxidative stress. Golimumab, an anti-TNF biologic, is prescribed for the management of numerous inflammatory ailments like psoriatic and rheumatoid arthritis, ulcerative colitis and ankylosing spondylitis.

Objective:
Current study has explored the effects of anti-TNF biologics golimumab on mice due to cisplatin-induced nephrotoxicity.

Method:
Renal toxicity was caused by administration of single cisplatin injection at 22 mg/kg by intraperitoneal (i/p) route. Golimumab (24 mg/kg, s.c.) was administered consecutively for 7 days. The parameters such as renal functions, oxidative stress, inflammation, and renal damage were evaluated on the 7th day of experiments.

Results:
Cisplatin administration caused nephrotoxicity as shown by a significant elevation of various parameters viz; serum creatinine, neutrophil gelatinase-associated lipocalin (NGAL), urea nitrogen (BUN), and cystatin C. There was a significant rise in urinary clusterin, kidney injury molecule 1 (KIM-1), and β-N-acetylglucosaminidase (NAG) concentrations in the animals treated with cisplatin. The markers of oxidative stress (malondialdehyde, reduced glutathione, and catalase), inflammation (IL-6, TNF-α, IL-10, IL-1β, MCP-1, ICAM-1, and TGF-β1), and apoptosis (caspase-3) were also altered in serum and/or kidneys of cisplatin animals. Further, cisplatin-caused histopathological changes in proximal tubular cells as observed in the H&E staining of renal tissue. Golimumab treatment reduced all markers of kidney injury and attenuated cell death. Golimumab significantly reduced inflammatory cytokines TNFα, IL- 6, MCP-1, IL- 1β, ICAM-1, and TGF-β1 and increased anti-inflammatory cytokine IL-10 in cisplatin-intoxicated mice.

Conclusion:
The study’s results suggest that golimumab prevented nephrotoxicity induced by cisplatin- through inhibition of oxidative stress, apoptotic cell death inflammatory response, thus improving renal function.
Green Synthesis, Characterization and Antimicrobial Activity of Silver
Nanoparticles Using Uraria picta Leaves Extract
Authors: Mishra Satyendra , Kumavat Sanjay 
Published: September 2021

Background:
The rapid synthesis and antimicrobial activity of silver nanoparticles (AgNPs)
synthesized using Uraria picta extract were investigated in this paper, and AgNPs were examined for
antimicrobial activity against a variety of pathogenic organisms, including bacteria and fungi.

Objective:
The main objective was to synthesize AgNPs from Uraria picta leaves extract by the technique
of green synthesis for antimicrobial evaluation against bacteria and fungi using MIC studies.

Methods:
The AgNPs were formed by treating an aqueous extract of Uraria picta leaves with silver nitrate
(1 mM) solution, and then nanoparticles were synthesized for various studies.

Results:
The Uraria picta leaves extract can be used for the green synthesis of AgNPs effectively. The
absorption band at 425 nm in the UV-Vis spectrum confirmed the synthesis of AgNPs. According to
MIC tests, silver nanoparticles exhibited antimicrobial and antifungal properties. This work will provide
a better understanding of the development of new antimicrobial and antifungal activities.

Conclusion:
We utilized Uraria picta aqueous leaves extract to develop a fast, cost-effective, ecofriendly,
and simple method for the synthesis of AgNPs, and the nanoparticles synthesized by this plant
for the first time demonstrated antimicrobial activity. AgNPs were observed to be spherical and oval in
shape, with average particle sizes ranging from 12.54 to 25.58 nm. The antimicrobial activity of AgNPs
was confirmed against typhi, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus by a significant
zone of inhibition.
Site selection arahan eksplorasi untuk konservasi ex situ tumbuhan dengan pendekatan spasial di Pulau Bali
Authors: Iryadi Rajif , Kurniawan Agung 
Published: September 2021

Abstrak Kebun Raya “Eka Karya” Bali (KREKB) melakukan eksplorasi tumbuhan di dataran tinggi kawasan timur Indonesia sebagai langkah awal dalam konservasi ex situ tumbuhan. Tujuan studi ini adalah untuk memberikan rekomendasi lokasi eksplorasi tumbuhan di Pulau Bali bagi KREKB. Metode penelitian menggunakan pendekatan analisis SIG berjenjang tertimbang secara spasial dan overlay pada parameter pembatas, yaitu: kawasan hutan dan historis eksplorasi, dengan variabel fisik seperti: bentuklahan, elevasi, tutupan vegetasi, dan penggunaan lahan. Hasil penelitian menunjukkan kawasan hutan di Kabupaten Jembrana (36.576,74 ha) dan Buleleng (32.424,87 ha) merupakan wilayah yang memenuhi kelas direkomendasikan - sangat direkomendasikan untuk eksplorasi tumbuhan. Kondisi lokasi yang sangat direkomendasikan memiliki cakupan yang sempit dengan tantangan medan yang berat, namun berpeluang tinggi untuk mendapatkan tumbuhan prioritas konservasi, baik sebagai koleksi baru maupun terancam kepunahan. Abstract As one of the main role in plant conservation, Bali Botanic Garden (BBG) has regularly conducted flora expeditions around the mountain areas in the eastern part of Indonesia. This study aimed to provide recommendations for BBG in terms of flora exploration sites in Bali. The methods used GIS analysis approach with spatially weighted tiers with scoring and overlay on the limiting parameters namely forest area and historical exploration, with other physical variables such as landform, elevation, vegetation cover, and land use. The results showed that forest area in Jembrana (36,576.74 ha) and Buleleng (32,244.87 ha) were the areas which met the recommended - highly recommended class for flora exploration. The highly recommended locations characterised by narrow area with a challenging hard terrain, however the chance of obtaining the priority plant for conservation, either new collections or threatened species, is higher.
Identidad Marron e o Labirinto do Minotauro.
Authors: Pucarelli Michele , Filgueiras Mathias Roberta 
Published: September 2021

Em um momento no qual tanto a pauta identitária quanto a intersseccionalidade são debatidos por várias ciências e em diversos espaços acadêmicos procuramos neste artigo apresentar um estudo de caso sobre a atuação do Colectivo Identidad Marron, que dialogue não somente com a precarização (constante em nosso continente), mas com possíveis saídas culturalmente inventivas e potentes. Formado em 2018 na cidade de Buenos Aires, o Identidad Marron é composto principalmente por mulheres em luta por uma inserção dos povos originários em melhores postos de trabalhos e por espaços de destaque em suas atividades artísticas. Pretendemos refletir se a cooptação e atuação delas no sistema de precarização não ressignificam sua inserção, conseguindo dar maior visibilidade as questões dos movimentos identitários na Argentina. Sendo parte de um contexto mais amplo de movimentos identitários, que norteiam o pensamento latino-americano e mundial, o Identidad Marron pode ser compreendido como exemplo de luta e resistência ao utilizarem as facilidades da globalização em seu benefício, ainda que tenham consciência das contundentes limitações impostas pelas agendas neoliberais econômicas das grandes cidades ocidentais. Dessa forma, entendemos que seus embates são como uma atualização do mito do labirinto do Minotauro. Embora permaneçam dentro do labirinto, o fazem em conjunto e sem deixar de lutar por espaços mais justos e igualitários. Desse modo, além de apresentar sua atuação, iremos trabalhar e refletir com dados que denunciam o aumento das desigualdades sociais nesses territórios ao mesmo tempo em que sugerimos que essas novas movimentações identitárias têm um forte traço de reativação dos movimentos políticos e sociais locais surgidos nas décadas anteriores e de uma afetividade advinda da rememoração de sua ancestralidade. Longe de olhar o passado como um lugar de chegada, são as atualizações desses processos que tornam mais significativos esses movimentos, liderados, em geral, por mulheres que são atravessadas por questões interseccionais.
LA ENSEÑANZA SUPERIOR NO APRENDE. UNA ESTRATEGIA PARA HACER UNIVERSAL A LA UNIVERSIDAD.
Authors: Sagüés Silva Alicia Fernanda 
Published: September 2021

Los contenidos estudiados en la Universidad son solamente producidos por sí misma, perdiendo todos los saberes de los Pueblos Originarios que las habitan, especialmente en forma de estudiantes incluidos gracias a las propuestas más progresistas. La endogamia académica impide aprender de los estudiantes e incorporar conocimientos y estrategias educativas propias de aquellos Pueblos. Aquí sintetizo 5 años de trabajo a cargo del Seminario de Investigación de la Carrera de Arquitectura de la Universidad de Los Lagos, donde entre el 35 y el 45 % de estudiantes pertenece a algún Pueblo Originario. Los saberes que ellos sistematizan bajo mi estímulo y orientación, son recogidos por sus propios entornos socio-culturales, enriqueciendo además a sus pares. Pero la Universidad aún no los incorpora.
INOVAÇÃO PEDAGÓGICA, DOCÊNCIA UNIVERSITÁRIA E O ENSINO REMOTO EMERGENCIAL NA UNIVERSIDADE: O SABER DE EXPERIÊNCIA NA DOCÊNCIA
Authors: Campani Adriana , Veras do Nascimento Navilta , Gomes da Silva Rejane Maria 
Published: September 2021

A inovação pedagógica na universidade é um processo educativo de tensionamento, desequilíbrio, conflito e ruptura com as formas existentes de exclusão e homogeneização cultural. Nesse sentido, à docência universitária cumpre o papel importante em criar novas formas de produção e relação com o conhecimento saindo da condição solitária e expositiva do mesmo para o lugar de produção do saber de experiência. No saber de experiência do docente universitário podemos encontrar janelas abertas para o diálogo com os saberes culturais que configuram as novas formas de sociabilidades existentes na universidade. Partindo desse princípio, o presente artigo objetiva abordar reflexões sobre o relato de experiência de uma docente universitária com o ensino on-line, no contexto do ensino remoto emergencial, evidenciando o saber de experiência como janelas abertas para uma docência inovadora.
CARTOGRAFIA AFETIVA DA EXPERIÊNCIA ESCOLAR: PENSANDO EM ESTRATÉGIAS DE ENFRENTAMENTO DOS IMPACTOS DA COVID-19 NA EDUCAÇÃO
Authors: Paz Beatriz , Bueno Marina 
Published: September 2021

Resumo: A pandemia da Covid-19 nos impôs um contexto mundial causador de uma série de perturbações, tais como: luto, medo, dificuldades materiais, angústias, letargia, impotência, incertezas sobre o futuro, dentre outras. Tal contexto nos convoca ainda mais a buscar estratégias de cuidado e proteção psicossocial, de modo a mitigar os efeitos da crise sanitária. Este trabalho pretende realizar uma discussão em torno da Cartografia Afetiva, enquanto método de pesquisa e intervenção que, pautada num certo modo de olhar, escutar, acolher e agir com (ou intervir sobre) o que se passa em cada um e deste no encontro com o outro, pode vir a contribuir para a construção de um cuidado colaborativo na educação no contexto da pandemia da Covid-19. A pertinência do método cartográfico como estratégia de escuta-intervenção no campo educacional aqui debatida é fruto das análises feitas a partir de um projeto que foi desenvolvido em 2019 em escolas públicas da rede municipal de educação do Rio de Janeiro.
O DILEMAS DAS REDES E A MODULAÇÃO DOS COMPORTAMENTOS DOS USUÁRIOS: O QUE ISSO TEM A VER COM OS PROCESSOS DE APRENDIZAGEM?
Authors: Sepúlveda Denize , De Aguiar Xavier Sepulveda Yuri 
Published: September 2021

Esse artigo tem por finalidade estabelecer algumas análises sobre o documentário “O Dilema das Redes” e sua relação com as modulações dos comportamentos dos usuários da internet. Defendemos que nesta relação se estabelecem processos de aprendizagens que interferem nas visões de mundo das pessoas, influenciando a conscientização crítica dos sujeitos. Nossas considerações provisórias apontam para a importância do papel da escola junto aes estudantes como forma de criar espaços de emancipação, para que possam tecer maneiras de enfrentamentos diante de situações opressoras vivenciadas por jovens em redes sociais.
A Covid járványról komplexitás-szemüvegen keresztül
Authors: VITRAI József 
Published: September 2021

Bevezetés
Tavaly augusztusban — illetve idén januárban — két kutatócsoport szokatlan módon vette szemügyre a járványt: a rendszertudomány ismereteit hasznosító komplexitás-szemüvegen keresztül.
Vélemény
Minthogy a komplex rendszerek viselkedése alapvetően kiszámíthatatlan, a védekezéshez szükséges erőforrásokat, intézkedéseket ennek megfelelően szükséges tervezni és biztosítani. Így a nem előre látható eseményekre is tekintettel érdemes egészségügyi, gazdasági és szociális tartalékokat, kapacitásokat képezni, továbbá célszerű gyors intézkedéseket megengedő jogszabályi kereteket előzetesen kialakítani és így tovább.
A járvány komplex rendszerként való értelmezése rávilágít arra, hogy a korábbitól eltérő irányítási mechanizmusok szükségesek. Az egyidejű és több szektort érintő döntéseket sokféle szaktudást felhasználva, a valós helyzet és a korábbi tapasztalatok alapján kell gyorsan meghozni, figyelemmel az intézkedések bizonytalan hatására. A jövőbeli járványok megelőzéséhez, hatásuk mérsékléséhez újszerű döntéselőkészítő mechanizmusokat, monitorozó és értékelő rendszereket kell kiépíteni.
A járvány arra is felhívta a figyelmet, hogy az emberi tevékenység a Földön oly mértékben meghatározóvá vált, hogy a környezet önfenntartó egyensúlyának megbontásával a klímaváltozás, a levegőszennyezés, a víz- és élelmiszerhiány mellett globális járványok révén is veszélyezteti az emberiség létét.
Következtetés
A Covid-járvány komplex sajátosságainak megértéséhez és az eredményes védekezéshez nélkülözhetetlen feltenni a komplexitás-szemüveget. A sikeres és összehangolt védekezéshez elengedhetetlen, hogy valamennyi érintett tisztában legyen a járvány komplex természetével. A komplexitás felismeréséhez széleskörű ismeretterjesztő kampány és hiteles kommunikációs források működtetése, illetve a képzés és továbbképzés ilyen irányú fejlesztése vezethet. A globális környezet egyensúlyának megbomlása jelentette veszély elhárításához, a kockázatok csökkentéséhez, azaz a környezeti és társadalmi erőforrások fenntartható hasznosítása érdekében sürgősen cselekedni kell.
Fiber digestibility in growing pigs fed common fiber-rich ingredients – A systematic review
Authors: Yang Pan , Zhao Jinbiao 
Published: September 2021

Abstract
The application of high-fiber ingredients in the swine feed industry has some limitations considering that high amounts of fiber are resistant to endogenous enzymatic degradation in the pig’s gut. However, there is growing interest in fiber fermentation in the intestine of pigs due to their functional properties and potential health benefits. Many strategies have been applied in feed formulations to improve utilization efficiency of fiber-rich ingredients and stimulate their prebiotic effects in pigs. This manuscript reviews chemical compositions, physical properties, and digestibility of fiber-rich diets formulated with fibrous ingredients for growing pigs. Evidences presented in this review indicate there is a great variation in chemical compositions and physical properties of fibrous ingredients, resulting in the discrepancy of energy and fiber digestibility in pig intestine. In practice, fermentation capacity of fiber components in the pig’s intestine can be improved using strategies, such as biological enzymes supplementation and feed processing technologies. Soluble dietary fiber (SDF) and insoluble dietary fiber (IDF), rather than neutral detergent fiber (NDF) and acid detergent fiber (ADF), are recommended in application of pig production to achieve precise feeding. Limitations of current scientific research on determining fiber digestibility and short chain fatty acids (SCFA) production are discussed. Endogenous losses of fiber components from non-dietary materials that result in underestimation of fiber digestibility and SCFA production are discussed in this review. Overall, the purpose of our review is to provide a reference for feeding the pig by choosing the diets formulated with different high-fiber ingredients.
Test of inhibitors for preventing corrosion of steel reinforcement in concrete
Authors: Jano Albana , Lame Alketa , Kokalari Efrosini 
Published: September 2021

Abstract
Concrete is more widely used than any other manmade material. The objective of this paper is to investigate the behavior of reinforced cement when migration corrosion and guar gum inhibitors are used. The concrete samples were exposed in aggressive media H2SO4 1 M and in the presence of 1∙10-3 M Cl-. Electrochemical measurements such as half-cell potential, polarization resistance and Tafel extrapolation methods were performed in order to obtain information on the corrosion behavior of the reinforcing steel in cement mortar. Results demonstrate high resistance polarization and low corrosion rate for concrete sample with inhibitor. The corrosion rate decreases approximately 95% in presence of locust bean gum and 80% in presence of migration inhibitor.
Influence of Multilayer Interlocked Fabrics Structure on Their Thermal Performance
Authors: Parés Ferran , Ventura Heura , Xavier Capdevila F. , Ardanuy Mònica 
Published: September 2021

AbstractThis paper examines the influence of weaving variables such as yarn count, number of layers, warp and weft ratio, materials of the top layer, weft density and interlocking cell shape, and size on the thermal performance of multilayer interlocked woven fabrics. A split-plot design was used to construct a total of 64 fabric structures, which were assessed for thermal performance in terms of resistance to convective, conductive, and radiative heat. It was found that, for equal weft density and yarn number, protective performance improved with the number of fabric layers and with the presence of air cells between these layers, especially if air was not trapped within and could rather pass freely between the cells. An optimal combination of factors for the thermal response to the three types of heat was established via a Derringer–a much needed desirability function. The results of this paper are useful for identifying the interaction between configuration parameters and thermal performance, and hence for the design of improved heat protective clothing.
Philichthys xiphiae (Copepoda; Philichthyidae) – an interesting cranium parasite of the swordfish Xiphias gladius collected from the Baltic Sea
Authors: Rolbiecki Leszek , Arciszewski Bartłomiej , Izdebska Joanna N. 
Published: September 2021

Abstract
The swordfish, Xiphias gladius Linnaeus, 1758, is a fish that sporadically enters the Baltic Sea. The present paper describes the identification of a very rarely recorded and poorly studied copepod of the family Philichthyidae – Philichthys xiphiae Steenstrup, 1862 – in a dead swordfish found on a sea beach in Dźwirzyno (Poland) in 2016. Philichthyidae are parasites inhabiting the sensory canals in the lateral line and skull bones of marine fish. In the present case, two P. xiphiae females were found, which constitutes the first record of the species in the Baltic area.
Effects of feed on fatty acid composition in muscles and gonads of the Chinese mitten crab (Eriocheir sinensis)
Authors: Zou Jianmin , Song Chao , Meng Shunlong , Hu Gengdong , Qiu Liping , Fan Limin , Chen Jiazhang 
Published: September 2021

Abstract
In this study, the effects of different feeds on fatty acid composition in the Chinese mitten crab (Eriocheir sinensis) were investigated. The fatty acid composition in the Chinese mitten crab was significantly correlated with the type of feed source provided. Differences between the feed groups pertained mainly five fatty acids: oleic acid, linoleic acid, palmitic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The content of EPA and DHA was higher in the group of frozen trash fish than in the group of formulated feed. On the other hand, the content of oleic acid, linoleic acid and palmitic acid was higher in the formulated feed group than in the frozen trash fish group. There were significant differences in the nutritional value of the Chinese mitten crab reared under different feed sources, i.e. Chinese mitten crabs reared with the frozen trash fish feed were larger than those reared with the formulated feed, especially as regards the ω-3/ω-6 PUFA ratio and essential fatty acid levels.