bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhino-orbito-Cerebral mucormycosis during COVID 19 pandemic in western Uttar Pradesh India
Authors: Srivastava Mohit , Gupta Keshav , Singh Veenita 
Published: November 2021

Mucormycosis (Black fungus) is a designated as a rare, rapidly progressive fatal disease of immunocompromised caused by saprophytic fungus of family mucorales. Early diagnosis with prompt medical and surgical treatment is the only tool available. Rhino-orbito-cerebral is the most common subtype. In India we saw a sudden rise in mucormycosis cases during second wave of COVID 19. This necessitated a systematic review of epidemic of mucormycosis in COVID 19.A Retrospective multi-centric study was conducted comprising of 51 cases of Rhino-orbito-cerebral mucormycosis with present or recent COVID19 in Western Uttar Pradesh positive status presenting to us during 14 April 2021- 31 May 2021.Either Type2 Diabetes Mellitus or history of recent use of steroids in high doses was present in all the patients. Contribution of virulence of the Delta strain B1.617.2 is significant. FESS with sino-nasal debridement contributes significantly towards mortality reduction and cost of total treatment by significantly reducing days of Liposomal Amphotericin B therapy.Early diagnosis with prompt medical and surgical management along with blood sugar control and avoiding use of high dose of steroids remain to key to mortality and morbidity reduction.
Gender diversity in leadership of listed companies
Authors: Stępień Małgorzata 
Published: November 2021

Purpose of the study: The article attempts to characterize the management style represented by women and its impact on company management. The study aims to analyze the situation in the field of women's participation in the bodies of companies listed on the Warsaw Stock Exchange in the context of the situation in the Polish labor market. Methodology: The analyzes were carried out based on data from a survey of 140 largest Polish listed companies conducted by CFA Society Poland and data published by the Central Statistical Office for 2015-2019. Main Findings: Women and men represent two different management styles. Women, representing different leadership styles, can provide new values, which will improve management and lead to an increase in the importance of enterprises. The number of educated women with high professional qualifications is increasing. However, as research shows, the share of women in management boards and supervisory boards in Poland is small. There are still large disproportions in wages between women and men and the process of unequal promotion of women to managerial positions. Applications of this study: Due to the dissemination of research results by researchers, changes to codes of good practice were initiated and many initiatives were taken around the world. Research can also contribute to the creation of organizations supporting and promoting the professional development of women, creating databases of managerial talents and extending activities promoting the participation of women in the management staff. Novelty/Originality of this Study: The issues discussed in the study and the conducted analysis of the situation of women in Poland contribute to the discussion on the equality of women in the labor market. The thematic area of ​​the problem of the low presence of women in supervisory boards and management boards should be considered poorly explored. More research is needed in this area and will allow researchers to compare results over many years.
PROSES PERUBAHAN SOSIAL PENGEMBANGAN WISATA PESISIR PAYANGAN DI DESA SUMBEREJO KECAMATAN AMBULU KABUPATEN JEMBER
Authors: Qurniawati Indah Tri , Puspaningrum Diah 
Published: November 2021

One of the touris destinations which recenltly developed massively is the Payangan Beach. This tourism destination develops quite rapidly, this condition allows a social change among the society. The location of the research using purposive method. This research using case study method. The informants are chosen by using purposive sampling. The data collection is conducted by using interview, non-participatory observation, and documentation study. The data analysis is conducted by using Miles and Huberman’s method. The result of this research reveals: (1) there are internal factors includes the finding of a new destination and external factor is the environmental change to cause the social changes to happen. (2) the pushing factors of the social change are open stratification of the society, people respect, and the future orientation. (3) The inhibition factor to alter the social change to happen is the limited capability of human resources. (4) the process of the social change which starts from the change channels. The next stage of the process of social change is the adjustment conducted by the institutions and society. The last stage of the process of social change is seen on the occurrence of disorganization and reorganization
Keywords : beach, social change, tourism destination
Peran Stakeholder terhadap Program Agroforestri dan Pendapatan Rumah Tangga Petani LMDH Rengganis Desa Pakis Kecamatan Panti
Authors: Setio Aji Nikolas Dwi , Soejono Djoko 
Published: November 2021

Forest management carried out by the Panti District community in collaboration with Perhutani is regulated through an agroforestrybased Social Forestry program. This study focuses on the role and contribution of stakeholders to the agroforestry program, the household income of agroforestry farmers and the contribution of the household income of agroforestry and non-agroforestry farmers. The research method uses analytical descriptive. The sampling method used purposive sampling and incidental sampling. The data collection method used primary and secondary data. The data analysis tool uses quantitative description, income analysis and analysis of household income contribution of agroforestry farmers. The results showed that: (1) LMDH Rengganis acts as a policy creator, coordinator, facilitator, and implementer. Perhutani has a role as coordinator, facilitator and accelerator. KLHK acts as a policy creator. SDInpres and Bank BRI have a role as a facilitator. Community Empowerment Team (TPM) as facilitator and accelerator. Cabang Dinas Kehutanan (CDK) Wilayah Jember as facilitator, coordinator and accelerator. Village government as coordinator; (2) The average income of agroforestry is Rp. 24,673,333/year and is classified as profitable; (3) The contribution of agroforestry to LMDH Rengganis farmers in Pakis Village, Panti Subdistrict is categorized as high with a percentage of 84%..
Keywords: Social forestry, agroforestry, stakeholders, role, and agroforestry income
Effectiveness of Clove Flower Extract (Syzygium Aromaticum L.) as Analgesic on Licking Time Reaction in Male Mice with Formalin Induction
Authors: Puspitasari Vina , Wahjuni Retno Sri , Saputro Amung Logam , Hamid Iwan Sahrial , Wibawati Prima Ayu 
Published: November 2021

This research is about testing the effectiveness of clove flower extract (Syzygium aromaticum L.) as an analgesic against the beating time caused by formalin male mice. This research is experimental with the Complete Random Design formula producing four times repetition (N = 4) and divided into five treatment groups (t = 5). Data were analyzed using ANAVA factorial test then followed by Duncan test. All tests are carried out with Product Solutions and Service Statistics (SPSS). The results of research and statistical analysis prove that clove flower extract at a dose of 1% is an effective dose compared to other treatment groups, seen from the amount of time licking male mice which is smaller than other treatment groups. It can be concluded that the administration of clove flower extract has analgesic effectiveness against the reaction of male mice induced by formalin. The concentration of clove flower extract 1% is the most effective in reducing licking time.
EXCESSO DE PESO EM ADULTOS DE UM MUNICÍPIO DE MINAS GERAIS EM 2019 E 2020
Authors: Cruz Ana Caroline da Silva , Flores Bicalho Juliana Mara , Borges Neto Juscelino de Sousa , Gomes Tulio Gonçalves 
Published: November 2021

Introdução: O excesso de peso é um dos fatores de risco para COVID-19 podendo levar ao desenvolvimento de manifestações mais severas da doença. O sobrepeso e a obesidade implicam uma condição de excesso de peso, que é caracterizado pelo acúmulo excessivo de gordura corporal e tem como causador principal a alimentação inadequada e o sedentarismo. Em 2020 com a ocorrência da pandemia COVID-19, parte da população teve que alterar a sua rotina, passando a trabalhar em home office, a não fazer exercícios físicos devido ao fechamento de academias, aumentando o consumo de alimentos calóricos por delivery e de álcool. Objetivos: Apresentar o estado nutricional de adultos (20 a 59 anos) acompanhados nas Unidades de Atenção Primária à Saúde através do Sistema de Vigilância Alimentar Nutricional - SISVAN em 2019 e 2020, ano do início da Pandemia. Método: Estudo descritivo. Para a classificação do estado nutricional de adultos, foi utilizado o índice de massa corporal (IMC) para adultos que leva em conta o peso e a estatura. Para cálculo do IMC divide-se o peso (em quilos), pela altura (em metros), elevada ao quadrado. O excesso de peso em adultos foi entendido nesse estudo pela soma de sobrepeso, obesidade I, II e III, ou seja, adultos com IMC maior ou igual a 25,0 kg/m². Resultados: Em 2019 foi registrado acompanhamento de 5867 adultos no SISVAN, que representa 4,5% dos adultos do município, sendo que 60,17% apresentavam excesso de peso. Em 2020, ano de início da pandemia de COVID-19, foi registrado 10523 acompanhamentos no SISVAN que representa 8% dos adultos do município, sendo 66,96% apresentavam excesso de peso de acordo com o IMC para adultos, o que representa um aumento de 11,3%. Conclusão: É importante o registro do estado nutricional de adultos pelo SISVAN para garantir um melhor diagnostico da prevalência do excesso de peso, a fim de conhecer o real quadro deste problema no município, durante e após o início da pandemia COVID-19, possibilitando traçar novas medidas para o enfrentamento do excesso de peso com incentivo à adoção da prática de exercício e mudança de hábitos alimentares.
Determinants of School Participation in Riau Province in 2019
Authors: Siddique Abdul Aliem , Heriqbaldi Unggul 
Published: November 2021

Education has an important role in economic development, not only in driving economic growth but also in breaking intergenerational poverty. For this reason, the Government of Indonesia has implemented a 12-year compulsory education program in the last decade. Through this program, it is hoped that school enrollment rates will increase and economic development will be of higher quality. However, the implementation of this program was not without obstacles. This study aims to analyze the determinants of school participation in Riau Province in 2019 using data from the National Socio-Economic Survey (SUSENAS). The results of this study indicate that the education of the head of the household, the level of welfare and gender have a significant effect on school participation of children aged 7-18 years.
Blended Learning menggunakan Whatsapp untuk Pembelajaran Anak Usia Dini
Authors: Miyanti Irma Nur 
Published: October 2021

Pandemi COVID-19 yang sedang terjadi saat ini telah menurunkan stabilitas pendidikan di Indonesia. Larangan untuk belajar secara tatap muka menyebabkan pembelajaran disekolah tidak dapat dilaksanakan. jika keadaan ini terus berlanjut, maka pendidikan akan mengalami keterpurukan. Keadaan seperti ini menjadi masalah krusial dalam dunia pendidikan yang perlu mendapatkan penanganan. Untuk mengatasi masalah pendidikan selama pandemi COVID – 19, perlu adanya inovasi pembelajaran yang dapat dilakukan supaya pendidikan dapat terus berlanjut dan potensi anak dapat terus berkembang. Penelitian Tindakan Kelas tentang Blended Learning dengan Whatsapp dapat Meningkatkan Pembelajarn Anak Usia Dini. Hasil penelitian tindakan kelas yang telah dilakukan di TK Dharma Wanita Sumberagung 3 yaitu: 1) keaktifan anak pada pembelajaran Blended Learning menggunakan Whatsapp pada siklus I sebesar 69% dan meningkat menjadi 89% pada siklus II, 2) ketuntasan anak siklus I sebesar 67% dan pada siklus II sebesar 86%. Berdasarkan hasil pada siklus I dan siklus II tersebut dapat disimpulkan bahwa pembelajaran Blended Learning dengan Whatsapp dapat meningkatkan pembelajaran anak usia dini.
AKTUALISASI NILAI-NILAI PANCASILA MELALUI REFORMULASI PERTANGGUNGJAWABAN PIDANA PADA KASUS PROSTITUSI ONLINE
Authors: Yuherawan Deni , Juita Subaidah Ratna 
Published: October 2021

Pembahasan dan pengkajian secara teoretis normatif mengenai pembaruan hukum pidana dalam penanggulangan tindak pidana berkaitan dengan pembaruan dalam subsistem substansi dari hukum pidana, serta merupakan pembangunan dalam sistem hukum Indonesia yang berorientasi pada perlindungan terhadap masyarakat. Salah satu usaha rasional yang digunakan untuk menanggulangi aktivitas prostitusi online adalah dengan pendekatan kebijakan hukum pidana melalui formulasi sanksi pidana sebagai wujud konkret pertanggungjawaban pidana pada pelaku prostitusi online. Belum adanya ketentuan yang mengatur mengenai pertanggungjawaban pidana kepada para pengguna jasa dalam kasus prostitusi online menyebabkan tidak maksimalnya penanggulangan prostitusi online itu sendiri. Apabila tidak ada pengaturan nasional yang mengatur tentang hal tersbut, maka para pengguna jasa prostitusi online akan merasa aman dan tetap leluasa membeli jasa untuk kepuasan mereka semata dan termasuk perempuan yang memberikan jasa layanan seks komersil (PSK), sementara hal tersebut bertentangan dengan berbagai aspek norma terutama norma kesusilaan dalam masyarakat sebagai salah satu pengejewantahan nilai-nilai Pancasila. Oleh karena itu diperlukan pembaruan hukum pidana, berkaitan dengan pertanggungjawaban pidana baik itu bagi para pengguna jasa prostitusi online maupun perempuan yang memberikan jasa layanan seks komersil (PSK). Dengan demikian, tulisan ini mengkaji mengenai aktualisasi nilai-nilai pancasila melalui reformulasi pertanggungjawaban pidana dalam kasus prostitusi online.
La cartografía temática como recurso idóneo para el conocimiento de la pandemia COVID-19: ejemplo de aplicación en España
Authors: Sancho Comíns José , Olcina Cantos Jorge 
Published: November 2021

La pandemia Covid-19 ha sido un fenómeno de extraordinario calado por su desgraciada incidencia en la elevada pérdida de vidas humanas y por los perniciosos efectos sociales y económicos que ha provocado en todo el mundo. Son numerosos los organismos internacionales, y también en cada país, que han usado el recurso cartográfico para mostrar su origen, evolución y efectos, difundiéndose profusamente los resultados en los medios de comunicación. La cartografía ofrece muchas posibilidades al usuario por el hecho de que éste pueda entablar un diálogo inteligente con el mapa en el que, a buen seguro, descubrirá matices inéditos y, sobre todo, podrá formular hipótesis bien fundamentadas que sostengan futuras investigaciones más específicas. En España, se ha desarrollado un proyecto cartográfico colaborativo entre el Instituto Geográfico Nacional y la Asociación Española de Geografía que ha tenido como resultado la edición de un Atlas sobre la pandemia Covid-19 en España. En este artículo, después de una breve introducción, se abordan aspectos conceptuales, metodológicos y organizativos que han sustentado la confección del atlas con aportación de una muestra de mapas que integran dicho atlas, a la vez que se analiza un elenco representativo de ejemplos internacionales de cartografía de la Covid-19.
Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress–activated NF-κB pathway
Authors: Wang Ping , Hu Guodong , Zhao Wen , Du Juan , You Menghan , Xv Mengying , Yang Hong , Zhang Min , Yan Fanf , Huang Mianbo , Wang Xueer , Zhang Lin , Chen Yinghua 
Published: November 2021

Abstract
Background: Increasing interest in the hazardous properties of zinc oxide nanoparticles (ZnO NPs), commonly used as ultraviolet filters in sunscreen, has driven efforts to study the percutaneous application of ZnO NPs to diseased skin; however, in-depth studies of toxic effects on melanocytes under conditions of epidermal barrier dysfunction remain lacking. Methods: Epidermal barrier dysfunction model mice were continuously exposed to a ZnO NP-containing suspension for up to 14 and even 49 days in vivo. Melanoma-like change and molecular mechanisms were also verified in human epidermal melanocytes treated with 5.0 µg·mL −1 ZnO NPs for 72 h in vitro. Results: ZnO NP application for 14 and 49 consecutive days induced melanoma-like skin lesions, dysregulated melanoma-associated gene expression, increased oxidative injury, inhibited apoptosis, and increased nuclear factor kappa B (NF-κB) p65 and Bcl-2 expression in melanocytes of skin with epidermal barrier dysfunction. Exposure to 5.0 µg·mL −1 ZnO NPs for 72 h increased cell viability, decreased apoptosis, and increased Fkbp51 expression in melanocytes, consistent with histological observations. The oxidative stress–mediated mechanism underlying the induction of anti-apoptotic effects was verified using the reactive oxygen species scavenger N-acetylcysteine. Conclusions: The entry of ZnO NPs into the stratum basale of skin with epidermal barrier dysfunction resulted in melanoma-like skin lesions and an anti-apoptotic effect induced by oxidative stress, activating the NF-κB pathway in melanocytes.
PLXDC2 Enhances Invadopodium Formation to Promote Invasion and Metastasis of Gastric Cancer Cells via Iteracting with PTP1B
Authors: Wu Bin , Wang Yan-xia , Wang Jun-jie , Xiang Dong-fang , Zhang Meng-si , Yan Ze-xuan , Wang Wen-ying , Miao Jing-ya , Lan Xi , Liu Jia-jia , Li Zheng-yan , Li Chuan , Fan Jun-yan , Liu Jun-yan , Jiang Lei , Zhan Ying , Xu Sen-lin , Cui You-hong , Qian Feng 
Published: November 2021

Abstract
Background: Plexin-domain containing 2 (PLXDC2) has been reported as an oncoprotein in several human malignancies. However, its expression and roles in gastric cancer remain largely unclear. Methods: The expression of PLXDC2 in 170 gastric cancer specimens was measured by using immunohistochemical staining and its clinical relevance was statistically analyzed. Matrigel-transwell invasion assays and mouse intraperitoneal metastasis models with PLXDC2-silencing and -overexpressing gastric cells were performed to explore the biological functions of PLXDC2 in gastric cancer cells. RNA-Seq, immunofluorescence and Co-IP analyses were used to investigate the potential molecular mechanisms of PLXDC2 action in gastric cancer. Results: PLXDC2 was highly expressed in gastric cancer tissues, and the expression levels were positively correlated with clinicopathological features, but negatively with the patients’ outcome. Cox regression analysis identified PLXDC2 as an independent prognostic indicator for the patients. Knockdown of PLXDC2 markedly suppressed the in vitro invasion and in vivo metastasis of gastric cancer cells, while overexpression of PLXDC2 resulted in opposite effects. Mechanistically, PLXDC2 inhibited dephosphorylation of phosphorylated Cortactin by physically interacting with PTP1B, an important tyrosine phosphatase, thereby promoting the formation of invadopodium. Conclusions: PLXDC2 contributes to the invasion and metastasis of gastric cancer by inhibiting PTP1B to facilitate the invadopodium formation, and may serve as a potential prognostic biomarker and a therapeutic target for this disease.
Kilometre-scale, kilowatt average power, single-mode laser delivery through hollow core fibre: overcoming nonlinear limits of glass fibre
Authors: Mulvad Hans Christian , Mousavi Seyed mohammad Abokhamis , Zuba Viktor , Xu Lin , Sakr Hesham , Bradley Thomas , Hayes John , Jasion Gregory , Fokoua Eric Numkam , Taranta Austin , Alam Shaif-ul , Richardson David , Poletti Francesco 
Published: November 2021

Abstract
High power laser delivery with near-diffraction-limited beam quality, widely used in industry for precision manufacturing, is typically limited to tens of metres distances by nonlinearity-induced spectral broadening inside the glass-core delivery fibres. Anti-resonant hollow-core fibres offer not only orders-of-magnitude lower non-linearity, but also loss and modal purity comparable to conventional beam-delivery fibres. Using a single-mode hollow-core nested anti-resonant nodeless fibre (NANF) with 0.74-dB/km loss, we demonstrate delivery of 1 kW of near-diffraction-limited continuous wave laser light over an unprecedented 1-km distance, with a total throughput efficiency of ~80%. From simulations, more than one order of magnitude further improvement in transmitted power or length should be possible in such air-filled fibres, and considerably more if the core is evacuated. This paves the way to multi-kilometre, kW-scale power delivery – not only for future manufacturing and subsurface drilling, but also for new scientific possibilities in sensing, particle acceleration and gravitational wave detection.
Sex-dependent Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment
Authors: Yang Zhengshi , Caldwell Jessica Z.K. , Cummings Jeffrey L. , Ritter Aaron , Kinney Jefferson W. , Cordes Dietmar 
Published: November 2021

Abstract
Purpose

To assess the pathological aging effect on caudate functional connectivity among mild cognitive impairment (MCI) participants and examine whether and how sex and amyloid contribute to this process.
Materials and Methods

277 functional magnetic resonance imaging (fMRI) sessions from 163 cognitive normal (CN) older adults and 309 sessions from 139 participants with MCI were included as the main sample in our analysis. Pearson’s correlation was used to characterize the functional connectivity (FC) between caudate and each brain region, then caudate nodal strength was computed to quantify the overall caudate FC strength. Association analysis between caudate nodal strength and age was carried out in MCI and CN separately using linear mixed effect (LME) model with covariates (education, handedness, sex, Apolipoprotein E4 and intra-subject effect). Analysis of covariance was conducted to investigate sex, amyloid status and their interaction effects on aging with the fMRI data subset having amyloid status available. LME model was applied to women and men separately within MCI group to evaluate aging effects on caudate nodal strength and each region’s connectivity with caudate. We then evaluated the roles of sex and amyloid status in the associations of neuropsychological scores with age or caudate nodal strength. An independent cohort was used to validate the sex-dependent aging effects in MCI.
Results

The MCI group had significantly stronger age-related increase of caudate nodal strength compared to the CN group. Analyzing women and men separately revealed that the aging effect on caudate nodal strength among MCI participants was significant only for women (left: P=6.23x10−7, right: P=3.37x10−8), but not for men (P>0.3 for bilateral caudate). The aging effects on caudate nodal strength were not significantly mediated by brain amyloid burden. Caudate connectivity with ventral prefrontal cortex substantially contributed to the aging effect on caudate nodal strength in women with MCI. Higher caudate nodal strength is significantly related to worse cognitive performance in women but not in men with MCI.
Conclusion

Sex modulates the pathological aging effects on caudate nodal strength in MCI regardless of amyloid status. Caudate nodal strength may be a sensitive biomarker of pathological aging in women with MCI.