bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent depression, early psychiatric comorbidities, and adulthood welfare burden: a 25-year longitudinal cohort study
Authors: Alaie Iman , Ssegonja Richard , Philipson Anna , von Knorring Anne-Liis , Möller Margareta , von Knorring Lars , Ramklint Mia , Bohman Hannes , Feldman Inna , Hagberg Lars , Jonsson Ulf 
Published: March 2021

Abstract
Purpose
Depression at all ages is recognized as a global public health concern, but less is known about the welfare burden following early-life depression. This study aimed to (1) estimate the magnitude of associations between depression in adolescence and social transfer payments in adulthood; and (2) address the impact of major comorbid psychopathology on these associations.

Methods
This is a longitudinal cohort study of 539 participants assessed at age 16–17 using structured diagnostic interviews. An ongoing 25-year follow-up linked the cohort (n = 321 depressed; n = 218 nondepressed) to nationwide population-based registries. Outcomes included consecutive annual data on social transfer payments due to unemployment, work disability, and public assistance, spanning from age 18 to 40. Parameter estimations used the generalized estimating equations approach.

Results
Adolescent depression was associated with all forms of social transfer payments. The estimated overall payment per person and year was 938 USD (95% CI 551–1326) over and above the amount received by nondepressed controls. Persistent depressive disorder was associated with higher recipiency across all outcomes, whereas the pattern of findings was less clear for subthreshold and episodic major depression. Moreover, depressed adolescents presenting with comorbid anxiety and disruptive behavior disorders evidenced particularly high recipiency, exceeding the nondepressed controls with an estimated 1753 USD (95% CI 887–2620).

Conclusion
Adolescent depression is associated with considerable public expenditures across early-to-middle adulthood, especially for those exposed to chronic/persistent depression and psychiatric comorbidities. This finding suggests that the clinical heterogeneity of early-life depression needs to be considered from a longer-term societal perspective.
Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon
Authors: Zhao Shensheng , Wesseling Sebastiaan , Spenkelink Bert , Rietjens Ivonne M. C. M. 
Published: March 2021

AbstractThe present study predicts in vivo human and rat red blood cell (RBC) acetylcholinesterase (AChE) inhibition upon diazinon (DZN) exposure using physiological based kinetic (PBK) modelling-facilitated reverse dosimetry. Due to the fact that both DZN and its oxon metabolite diazoxon (DZO) can inhibit AChE, a toxic equivalency factor (TEF) was included in the PBK model to combine the effect of DZN and DZO when predicting in vivo AChE inhibition. The PBK models were defined based on kinetic constants derived from in vitro incubations with liver fractions or plasma of rat and human, and were used to translate in vitro concentration–response curves for AChE inhibition obtained in the current study to predicted in vivo dose–response curves. The predicted dose–response curves for rat matched available in vivo data on AChE inhibition, and the benchmark dose lower confidence limits for 10% inhibition (BMDL10 values) were in line with the reported BMDL10 values. Humans were predicted to be 6-fold more sensitive than rats in terms of AChE inhibition, mainly because of inter-species differences in toxicokinetics. It is concluded that the TEF-coded DZN PBK model combined with quantitative in vitro to in vivo extrapolation (QIVIVE) provides an adequate approach to predict RBC AChE inhibition upon acute oral DZN exposure, and can provide an alternative testing strategy for derivation of a point of departure (POD) in risk assessment.
Non-analyticity of the Correlation Length in Systems with Exponentially Decaying Interactions
Authors: Aoun Yacine , Ioffe Dmitry , Ott Sébastien , Velenik Yvan 
Published: March 2021

AbstractWe consider a variety of lattice spin systems (including Ising, Potts and XY models) on $$\mathbb {Z}^d$$

Z

d

with long-range interactions of the form $$J_x = \psi (x) e^{-|x|}$$

J
x

=
ψ

(
x
)

e

-
|
x
|

, where $$\psi (x) = e^{{\mathsf o}(|x|)}$$

ψ

(
x
)

=

e

o
(
|
x
|
)

and $$|\cdot |$$

|
·
|

is an arbitrary norm. We characterize explicitly the prefactors $$\psi $$
ψ
that give rise to a correlation length that is not analytic in the relevant external parameter(s) (inverse temperature $$\beta $$
β
, magnetic field $$h$$
h
, etc). Our results apply in any dimension. As an interesting particular case, we prove that, in one-dimensional systems, the correlation length is non-analytic whenever $$\psi $$
ψ
is summable, in sharp contrast to the well-known analytic behavior of all standard thermodynamic quantities. We also point out that this non-analyticity, when present, also manifests itself in a qualitative change of behavior of the 2-point function. In particular, we relate the lack of analyticity of the correlation length to the failure of the mass gap condition in the Ornstein–Zernike theory of correlations.
Distribution of rorquals and Atlantic cod in relation to their prey in the Norwegian high Arctic
Authors: Solvang Hiroko K. , Haug Tore , Knutsen Tor , Gjøsæter Harald , Bogstad Bjarte , Hartvedt Siri , Øien Nils , Lindstrøm Ulf 
Published: March 2021

AbstractRecent warming in the Barents Sea has led to changes in the spatial distribution of both zooplankton and fish, with boreal communities expanding northwards. A similar northward expansion has been observed in several rorqual species that migrate into northern waters to take advantage of high summer productivity, hence feeding opportunities. Based on ecosystem surveys conducted during August–September in 2014–2017, we investigated the spatial associations among the three rorqual species of blue, fin, and common minke whales, the predatory fish Atlantic cod, and their main prey groups (zooplankton, 0-group fish, Atlantic cod, and capelin) in Arctic Ocean waters to the west and north of Svalbard. During the surveys, whale sightings were recorded by dedicated whale observers on the bridge of the vessel, whereas the distribution and abundance of cod and prey species were assessed using trawling and acoustic methods. Based on existing knowledge on the dive habits of these rorquals, we divided our analyses into two depth regions: the upper 200 m of the water column and waters below 200 m. Since humpback whales were absent in the area in 2016 and 2017, they were not included in the subsequent analyses of spatial association. No association or spatial overlap between fin and blue whales and any of the prey species investigated was found, while associations and overlaps were found between minke whales and zooplankton/0-group fish in the upper 200 m and between minke whales and Atlantic cod at depths below 200 m. A prey detection range of more than 10 km was suggested for minke whales in the upper water layers.
Comparison of clinical outcomes and left ventricular remodeling after ST-elevation myocardial infarction between patients with and without diabetes mellitus
Authors: Akashi Naoyuki , Tsukui Takunori , Yamamoto Kei , Seguchi Masaru , Taniguchi Yousuke , Sakakura Kenichi , Wada Hiroshi , Momomura Shin-ichi , Fujita Hideo 
Published: March 2021

AbstractLeft ventricular remodeling (LVR) after ST-elevation myocardial infarction (STEMI) is generally thought to be an adaptive but compromising phenomenon particularly in patients with diabetes mellitus (DM). However, whether the extent of LVR is associated with poor prognostic outcome with or without DM after STEMI in the modern era of reperfusion therapy has not been elucidated. This was a single-center retrospective observational study. Altogether, 243 patients who were diagnosed as having STEMI between January 2016 and March 2019, and examined with echocardiography at baseline (at the time of index admission) and mid-term (from 6 to 11 months after index admission) follow-up were included and divided into the DM (n = 98) and non-DM groups (n = 145). The primary outcome was major adverse cardiovascular events (MACEs) defined as the composite of all-cause death, heart failure (HF) hospitalization, and non-fatal myocardial infarction. The median follow-up duration was 621 days (interquartile range: 304–963 days). The DM group was significantly increased the rate of MACEs (P = 0.020) and HF hospitalization (P = 0.037) compared with the non-DM group, despite of less LVR. Multivariate Cox regression analyses revealed that the patients with DM after STEMI were significantly associated with MACEs (Hazard ratio [HR] 2.79, 95% confidence interval [CI] 1.20–6.47,P = 0.017) and HF hospitalization (HR 3.62, 95% CI 1.19–11.02,P = 0.023) after controlling known clinical risk factors. LVR were also significantly associated with MACEs (HR 2.44, 95% CI 1.03–5.78,P = 0.044) and HF hospitalization (HR 3.76, 95% CI 1.15–12.32,P = 0.029). The patients with both DM and LVR had worse clinical outcomes including MACEs and HF hospitalization, suggesting that it is particularly critical to minimize LVR after STEMI in patients with DM.
A Safe Way to Administer Drugs Through a Nutrition Tube—The Simple Suspension Method
Authors: Kunieda Kenjiro , Kurata Naomi , Yoshimatsu Yuki , Ohno Tomohisa , Shigematsu Takashi , Fujishima Ichiro 
Published: March 2021

AbstractThe simple suspension method (SSM), developed by Kurata in 1997, is a way to suspend tablets and capsules in warm water for decay and suspension prior to their administration. This method is safe and has various advantages such as the avoidance of tube clogging and the loss of the drug. This study aimed to investigate whether a higher percentage of commonly used drugs could pass through nutrition tubes effectively using SSM, relative to that using the conventional crushing method. A tablet or capsule was inserted into a 20 mL syringe with warm water (at 55 °C). After 10 min, it was shaken in the syringe. The suspension liquid was injected into tubes of the following sizes: 8 Fr, 10 Fr, 12 Fr, 14 Fr, 16 Fr, and 18 Fr. A total of 3686 tablets and 432 capsules that are frequently used in Japan were tested. Using SSM, 3377 (91.6%) tablets and 359 (83.1%) capsules disintegrated within 10 min and passed through the tube without clogging it in the tube passage test. With the conventional crushing method, 2117 tablets (57.4%) and 272 capsules (63.0%) could be crushed. SSM reduced the risk of tube clogging and drug loss with more drugs than that with the conventional crushing method. The number of drugs indicated for administration by SSM is greater than that indicated by the conventional crushing method. Further studies are needed to consider its utility compared to conventional methods for dysphagia patients in clinical settings.
A behavior-based framework for safe deployment of humanoid robots
Authors: Scianca Nicola , Ferrari Paolo , De Simone Daniele , Lanari Leonardo , Oriolo Giuseppe 
Published: March 2021

AbstractWe present a complete framework for the safe deployment of humanoid robots in environments containing humans. Proceeding from some general guidelines, we propose several safety behaviors, classified in three categories, i.e., override, temporary override, and proactive. Activation and deactivation of these behaviors is triggered by information coming from the robot sensors and is handled by a state machine. The implementation of our safety framework is discussed with respect to a reference control architecture. In particular, it is shown that an MPC-based gait generator is ideal for realizing all behaviors related to locomotion. Simulation and experimental results on the HRP-4 and NAO humanoids, respectively, are presented to confirm the effectiveness of the proposed method.
Scientific Realism and Further Underdetermination Challenges
Authors: Alai Mario 
Published: March 2021

AbstractIn an earlier article on this journal I argued that the problem of empirical underdetermination can for the largest part be solved by theoretical virtues, and for the remaining part it can be tolerated. Here I confront two further challenges to scientific realism based on underdetermination. First, there are four classes of theories which may seem to be underdetermined even by theoretical virtues. Concerning them I argue that (i) theories produced by trivial permutations and (ii) “equivalent descriptions” are compatible with the truth of standard theories; instead (iii) “as if” versions of standard theories are much worse from the point of view of theoretical virtues; finally (iv) mathematically intertranslatable theories either may become empirically decidable in the future, or can be discriminated by theoretical virtues, or realists may simply plead ignorance about their claims. Secondly, I consider Stanford’s underdetermination with respect unconceived alternatives, arguing that it essentially relies on the pessimistic meta-induction from the falsity of all past theories. Therefore, it can be resisted by (a) considering the radical advancement of present with respect to past science, and (b) arguing with selective realism that past successful theories, even if false, always included some true components.
Low CO2 evasion rate from the mangrove-surrounding waters of the Sundarbans
Authors: Akhand Anirban , Chanda Abhra , Watanabe Kenta , Das Sourav , Tokoro Tatsuki , Chakraborty Kunal , Hazra Sugata , Kuwae Tomohiro 
Published: March 2021

AbstractGlobally, water bodies adjacent to mangroves are considered significant sources of atmospheric CO2. We directly measured the partial pressure of CO2 in water [pCO2(water)] and related biogeochemical parameters with high temporal resolution, covering both diel and tidal cycles, in the mangrove-surrounding waters around the northern Bay of Bengal during the post-monsoon season. Mean pCO2(water) was marginally oversaturated in two creeks (470 ± 162 µatm, mean ± SD) and undersaturated in the adjoining estuarine stations (387 ± 58 µatm) compared to atmospheric pCO2, and was considerably lower than the global average. We further estimated the pCO2(water) and buffering capacity of all possible sources of the mangrove-surrounding waters and concluded that their character as a CO2 sink or weak source is due to the predominance of marine water from the Bay of Bengal with low pCO2 and high buffering capacity. Marine water with high buffering capacity suppresses the effect of pCO2 increase within the mangrove system and lowers the CO2 evasion even in creek stations. The δ13C of dissolved inorganic carbon (DIC) in the mangrove-surrounding waters indicated that the DIC sources were a mixture of mangrove plants, pore-water, and groundwater, in addition to marine water. Finally, we showed that the CO2 evasion rate from the estuaries of the Sundarbans is much lower than the recently estimated world average. Our results demonstrate that mangrove areas having such low emissions should be considered when up-scaling the global mangrove carbon budget from regional observations.
On the objectivity of the nonlinear along-fibre shear stress–strain relationship for unidirectionally fibre-reinforced composites
Authors: Li Shuguang , Xu Mingming , Yan Shibo , Sitnikova Elena 
Published: March 2021

AbstractThe nonlinear along-fibre shear stress–strain relationship for unidirectionally fibre-reinforced composites has been investigated in this paper aiming at its applications in general 3D stress conditions in a consistent manner. So far, such relationship has only been addressed in plane stress conditions. In this paper, it has been shown that its straightforward generalisation to 3D stress states lacks objectivity, which is a basic requirement for all theoretical studies of physical problems. A new formulation is proposed based on the stress invariants and the complementary strain energy guided by the rational theoretical framework of nonlinear elasticity. A consistent and objective stress–strain relationship has been obtained and verified through an example of application to a torsion problem.
State-of-the art review: Noncompaction cardiomyopathy in pediatric patients
Authors: Rohde Sofie , Muslem Rahatullah , Kaya Emrah , Dalinghaus Michel , van Waning Jaap I. , Majoor-Krakauer Danielle , Towbin Jeffery , Caliskan Kadir 
Published: March 2021

AbstractNoncompaction cardiomyopathy (NCCM) is a disease characterized by hypertrabeculation, commonly hypothesized due to an arrest in compaction during fetal development. In 2006, NCCM was classified as a distinct form of cardiomyopathy (CMP) by the American Heart Association. NCCM in childhood is more frequently familial than when diagnosed in adulthood and is associated with other congenital heart diseases (CHDs), other genetic CMPs, and neuromuscular diseases (NMDs). It is yet a rare cardiac diseased with an estimated incidence of 0.12 per 100.000 in children up to 10 years of age. Diagnosing NCCM can be challenging due to non-uniform diagnostic criteria, unawareness, presumed other CMPs, and presence of CHD. Therefore, the incidence of NCCM in children might be an underestimation. Nonetheless, NCCM is the third most common cardiomyopathy in childhood and is associated with heart failure, arrhythmias, and/or thromboembolic events. This state-of-the-art review provides an overview on pediatric NCCM. In addition, we discuss the natural history, epidemiology, genetics, clinical presentation, outcome, and therapeutic options of NCCM in pediatric patients, including fetuses, neonates, infants, and children. Furthermore, we provide a simple classification of different forms of the disease. Finally, the differences between the pediatric population and the adult population are described.
On Decoupling in Banach Spaces
Authors: Cox Sonja , Geiss Stefan 
Published: March 2021

AbstractWe consider decoupling inequalities for random variables taking values in a Banach space X. We restrict the class of distributions that appear as conditional distributions while decoupling and show that each adapted process can be approximated by a Haar-type expansion in which only the pre-specified conditional distributions appear. Moreover, we show that in our framework a progressive enlargement of the underlying filtration does not affect the decoupling properties (in particular, it does not affect the constants involved). As a special case, we deal with one-sided moment inequalities for decoupled dyadic (i.e., Paley–Walsh) martingales and show that Burkholder–Davis–Gundy-type inequalities for stochastic integrals of X-valued processes can be obtained from decoupling inequalities for X-valued dyadic martingales.
Nonlinear phenomena of contact in multibody systems dynamics: a review
Authors: Corral Eduardo , Moreno Raúl Gismeros , García M. J. Gómez , Castejón Cristina 
Published: March 2021

AbstractIn the present work, an introduction to the contact phenomena in multibody systems is made. The different existing approaches are described, together with their most distinctive features. Then, the term of coefficient of restitution is emphasized as a tool to characterize impact events and the algorithm for calculating the relative indentation between two convex-shaped bodies is developed. Subsequently, the main penalty contact models developed in the last decades are presented and developed, analysing their advantages and drawbacks, as well as their respective applications. Furthermore, some models with specific peculiarities that could be useful to the reader are included. The aim of this work is to provide a resource to the novice researcher in the field to facilitate the choice of the appropriate contact model for their work.
Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images
Authors: Niemann Annika , Voß Samuel , Tulamo Riikka , Weigand Simon , Preim Bernhard , Berg Philipp , Saalfeld Sylvia 
Published: March 2021

Abstract
Purpose
For the evaluation and rupture risk assessment of intracranial aneurysms, clinical, morphological and hemodynamic parameters are analyzed. The reliability of intracranial hemodynamic simulations strongly depends on the underlying models. Due to the missing information about the intracranial vessel wall, the patient-specific wall thickness is often neglected as well as the specific physiological and pathological properties of the vessel wall.

Methods
In this work, we present a model for structural simulations with patient-specific wall thickness including different tissue types based on postmortem histologic image data. Images of histologic 2D slices from intracranial aneurysms were manually segmented in nine tissue classes. After virtual inflation, they were combined into 3D models. This approach yields multiple 3D models of the inner and outer wall and different tissue parts as a prerequisite for subsequent simulations.

Result
We presented a pipeline to generate 3D models of aneurysms with respect to the different tissue textures occurring in the wall. First experiments show that including the variance of the tissue in the structural simulation affect the simulation result. Especially at the interfaces between neighboring tissue classes, the larger influence of stiffer components on the stability equilibrium became obvious.

Conclusion
The presented approach enables the creation of a geometric model with differentiated wall tissue. This information can be used for different applications, like hemodynamic simulations, to increase the modeling accuracy.
A leverage points perspective on institutions for food security in a smallholder-dominated landscape in southwestern Ethiopia
Authors: Jiren Tolera Senbeto , Riechers Maraja , Bergsten Arvid , Fischer Joern 
Published: March 2021

AbstractDespite concerted efforts, achieving the goal of universal food security remains challenging. Food security interventions occur at different levels of systemic depth. Some interventions target visible supply-side gaps, while others focus on deeper systemic problems in the food system. Here, we used a leverage points perspective to ask how multiple types of more superficial (shallow) and more fundamental (deep) interventions in the food system interact. Focusing on a case study in southwestern Ethiopia, we examined (1) recent changes in formal and informal institutions related to food security; (2) the effects of formal and informal institutions on the food system at different levels of systemic depth (i.e., on parameters, feedbacks, design, and intent); and (3) issues of institutional interplay between formal and informal institutions. We surveyed 150 rural households and analyzed key policy documents. Both formal and informal institutions were perceived to improve food security. However, at the intent level, formal institutions primarily aimed to enhance food supply, while informal institutions additionally sought to build trust among farmers. At the design level, formal interventions targeted information flow through a newly created agricultural extension system, while informal institutions facilitated labor sharing and communication. In terms of institutional interplay, new formal institutions had partly undermined pre-existing informal institutions. We conclude that both visible supply-side gaps and deeper drivers of food insecurity should be targeted through food security interventions. Interventions need to be cognizant of potentially unexpected ways of institutional interplay, especially between formal and informal institutions.