bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Retrospective Analysis of Biosimilar and Reference Trastuzumab in Human Epidermal Growth Factor Receptor-2 Positive Early and/or Locally Advanced Breast Cancer Patients Treated with Neoadjuvant-Adjuvant Setting
Authors: Kulkarni Rahul , Kulkarni Shriniwas , Pathan Almas , Nag Shona 
Published: December 2021

Background:
There is limited real-world evidence on the treatment outcomes with Trastuzumab, specifically with biosimilars. This analysis aims to evaluate the safety and effectiveness of Trastuzumab in early and/or locally advanced breast cancer patients treated with neoadjuvant-adjuvant treatment in the real world setting and to compare biosimilar with reference trastuzumab.

Materials and Methods:
We retrospectively analyzed the data of patients with human epidermal growth factor receptor-2 (HER-2)-positive breast cancers, who were treated with trastuzumab-based standard therapies. The survival curves were generated using the Kaplan–Meier method. Event-free survival (EFS) was calculated. All patients were assessed for toxicity as per CTCAE version 4.0. The subgroup analysis was carried out to compare the effectiveness of biosimilar with reference trastuzumab.

Results:
A total of 88 patients were evaluated from 2008 to 2018. EFS at 1, 2, and 5-year was 89.5%, 78%, and 44.2%, respectively. The median EFS was 43 months. In subgroup analysis, the 1, 2-, and 3-year EFS rates were 86.7%, 86.7%, and 57.8%, respectively, for reference Trastuzumab (n = 29) as compared to 91%, 74.4%, and 56.9%, respectively, for Biosimilar Trastuzumab (n = 59). Similarly, median EFS was 43 months and not reached, respectively. There was no significant difference in EFS between the two groups (P = 0.991). A significant asymptomatic decrease in the left ventricular ejection fraction (LVEF) of ≥10% to below the lower limit of normal was noted in only two patients (2.3%). There was no significant difference observed in reduction of LVEF to below the lower limit of normal between the two groups (P = 0.514). The common grade 3/4 adverse events (AEs) observed such as vomiting, diarrhea, pancytopenia, and anemia were mostly due to chemotherapy. These AEs were comparable in both groups.

Conclusions:
The EFS in our study is consistent with the historical data. Safety and effectiveness of biosimilars were comparable to the reference transtuzumab.
MiR 206 inhibits reorganization of the cytoskeleton in melanoma cells by targeting DDX5
Authors: Wu Shenglin , Nie Shan , Wang Jian 
Published: December 2021

Purpose: To investigate the role and mechanism of microRNA-206 (miR-206) in cytoskeleton reorganization in melanoma cells.
Methods: MiR-206 and RNA helicase p68 (DDX5) expression levels were measured in A375, A875, and HEM-M cells by quantitative real time polymerase chain reaction (qRT-PCR). A DDX5 overexpression cell line was constructed, and DDX5 overexpression, A375, and A875 cells were transfected with miR-206 mimic or DDX5 small interfering RNA (siRNA). Transwell assay was used to assess cell migration and invasion of A375 and A875 cells, while Luciferase reporter assay was used to determine the putative target of miR-206. DDX5, miR-206, vinculin, coronin3, and ezrin expression levels were evaluated by qRT-PCR. Protein expressions of DDX5, vinculin, coronin3, and ezrin were evaluated by western blot analysis.
Results: DDX5 expression was higher and miR-206 expression lower in A375 and A875 cells when compared to HEM-M cells (p < 0.05). Knockdown of DDX5 and overexpression of miR-206 repressed invasion and migration, and inhibited expression of vinculin, coronin3, and ezrin in A375 and A875 cells (p < 0.05). However, overexpression of DDX5 reversed the effect of miR-206 on cytoskeletal protein expression. Luciferase reporter assay data confirmed that DDX5 is a direct target of miR-206 (p < 0.05).
Conclusion: MiR-206 suppresses reorganization of the cytoskeleton in melanoma cells by targeting DDX5, and is thus, a promising target for the treatment of melanoma.
Human communities living in the central Campania Plain during eruptions of Vesuvius and Campi Flegrei
Authors: Mauro Antonio Di Vito  , Paola Aurino  , Giuliana Boenzi  , Elena Laforgia  , Ilaria Rucco  
Published: December 2021

Archaeological and volcanological studies have revealed that eruptions of Neapolitan volcanoes have conditioned human settlement patterns since prehistoric times. The occurrence of high intensity explosive eruptions, interspersed with long periods of quiescence, has characterized the last 10 ka of activity of these volcanoes. Geoarchaeological studies, carried out in advance of investigations for the construction of the Rome-Naples and the new Naples-Bari railway lines, have made possible a detailed reconstruction of human presence in the central part of the Campania Plain up to the coastal strip, between the late Neolithic and the late Bronze Age. The examined chronological interval includes sequences of pyroclastic deposits erupted by both Campi Flegrei and Somma-Vesuvius, and paleosols with evidence of anthropic frequentation. Altogether, the geoarchaeological data have provided a detailed picture of human settlement and activities through time with a particular focus on a long period of quiescence of the two volcanoes and also during their intense activity.
Smartphone-based active vaccine safety surveillance (SmartVax) at a Swiss adult vaccination clinic – a pilot study
Authors: Guedel Daniela S. , Peters Ian J. , Banderet Florian , Epple Varenka , Egli Sabine , Mehling Matthias , Mayr Michael , Leeb Alan , Berger Christoph T. 
Published: December 2021

INTRODUCTION: Post-licensure surveillance of adverse events following immunisation (AEFI) is critical for detecting rare but severe AEFI. SmartVax software, using smartphone technology, actively solicits reports of AEFI via automated, opt-out SMS surveys to vaccine recipients in the days following immunisation. We report on a pilot study to test the feasibility and acceptance of SmartVax in Switzerland.
METHODS: Between February and September 2020, consecutive subjects immunised at an adult immunisation clinic and the employee health service at the University Hospital of Basel were screened. Participants included three subgroups: healthcare workers (HCW), subjects with immune-mediated inflammatory diseases (IMID) and clients of the regular adult immunisation clinic. Three days after vaccination, participants received an SMS inquiring if they had any AEFI. In the case of an AEFI, subjects received an automated SMS with a link to an online survey assessing the type and temporal evolution of the AEFI. Descriptive statistics of response rate, time-to-response, frequency and type of AEFI by vaccine and clinical subgroup were performed.
RESULTS: Of 293 subjects screened, 276 were included (46.6% routine vaccination check-up visits, 33.3% HCW, 20.1% IMID patients) receiving 625 vaccinations during 360 immunisation visits. The SMS response rate was high (90.3%), with a median time-to-respond of 47 minutes (interquartile range11–205). After 29.8% of immunisation visits at least one AEFI was reported. There were no differences in frequency or type of AEFI between the three clinical subgroups. The recombinant, adjuvanted zoster vaccine Shingrix® was associated with the highest rate of local and systemic reactions.
CONCLUSION: Monitoring post-licensure vaccine safety using the active SMS-based surveillance system SmartVax is feasible in Switzerland. We observed a high acceptance in the diverse study population, including healthcare workers and IMID patients. High response rates in the elderly and reliable monitoring almost in real-time make SmartVax a promising tool for COVID-19 vaccine safety monitoring.
İlkel Toplumda Sosyo-Ekonomik Hayata Bir Bakış
Authors: YURTSEVEN Ahmet 
Published: December 2021

Sosyal bir varlık olan insan toplum içerisinde yaşar. Toplum ise sürekli değişme ve gelişme içerisinde olmuştur. Tarihi süreç içerisinde insanlar; ilkel toplum, köleci toplum, tarım toplumu gibi merhalelerden geçmiştir.
İlkel topluluk dönemi insanları, uzun süre küçük topluluklar halinde yaşamış, doğaya karşı da ilkel iş aletleri olan taş ve sopa ile mücadele vermiş ve yakın çevresinde ulaşabildiği yiyeceklerle hayatını sürdürmüştür. Belli bir zaman sonra en az tehlikeli olabilecek hayvanları avlamak suretiyle avcılık faaliyetine başlayan ilkel insanlar daha sonra da hayvanların evcilleştirilerek yetiştirmeleri demek olan çobanlık, bahçe tarımı ve zirai faaliyet yapmaya başlamıştır.
Avcılık ve toplayıcılıktan yerleşik hayata geçmeye başlayan ilkel insanların karşılaştıkları temel problemler savunma, beslenme ve üreme olarak ortaya çıkmıştır. Bu problemler aynı zamanda ilkel insan grupları arasında iş birliğin gelişmesini sağlamıştır.
Gambaran Tingkat Kecemasan Pada Pasien Yang Menjalani Hemodialisa : Literature Review
Authors: Gunawan Adi , Kamalah Aisyah Dzil 
Published: December 2021

AbstractPatients with chronic renal failure undergo hemodialysis for survival. Commonly, the hemodialysis process causes anxiety, which is related to machines and equipment, blood-flowing tubes and the process that takes 2 to 3 hours. This study aimed to describe the level of anxiety in patients undergoing hemodialysis. This study applied literature review. Articles were searched from PubMed, Garba Referral Digital (GARUDA), and ResearchGate according to inclusion and exclusion criteria. There are 5 articles met the criteria. More than half (65,8%) was male, 281 respondents (40,9%) have secondary education level, and majority (78%) of the respondents were not working 489. Around 58,7% of the respondents experienced of hemodialysis for 1 year. 358 respondents (52,1%) were categorized in mild anxiety. The majority of patients undergoing hemodialysis experienced mild anxiety. Accordingly, hospitals or health facilities can improve nursing care to treat anxiety in chronic kidney failure patients undergoing hemodialysis.Keywords: Anxiety, Chronic Kidney Failure, Hemodialysis.
AbstrakPasien gagal ginjal kronik menjalani hemodialisa demi kelangsungan hidupnya. Proses hemodialisa seringkali menimbulkan perasaan cemas dikarenakan mesin dan peralatan yang serba asing, selang-selang yang dialiri darah serta prosesnya yang membutuhkan waktu 2 sampai 3 jam. Penelitian ini bertujuan untuk mengetahui gambaran tingkat kecemasan pada pasien yang menjalani hemodialisa berdasarkan literature review. Penelitian ini merupakan penelitian deskriptif, metode yang digunakan dalam penelitian ini adalah literatur review dengan penelusuran online dari PubMed, Garba Rujukan Digital (GARUDA) dan ResearchGate sesuai kriteria inklusi yaitu artikel tahun 2011 sampai 2021 serta artikel yang ditulis dalam bahasa Indonesia dan bahasa Inggris. Hasil penelusuran didapatkan 5 artikel tahun 2014 sampai 2020. Karakteristik jenis kelamin pada literature review ini laki – laki 432 responden (65,8%) dari 657 responden, tingkat pendidikan menengah 281 responden (40,9%) dari 687 responden, jenis pekerjaan tidak bekerja 489 responden (78%) dari 627 responden, dan lama hemodialisa ≤1Tahun 88 responden (58,7%) dari 150 responden. Tingkat kecemasan terbanyak adalah kecemasan ringan dengan jumlah 358 responden (52,1%) dari 687 responden. Pasien yang menjalani hemodialisa mayoritas mengalami kecemasan ringan, jadi bagi rumah sakit atau sarana kesehatan agar dapat melakukan penatalaksanaan untuk menurunkan tingkat kecemasan dengan teknik distraksi maupun relaksasi.Kata Kunci: Gagal Ginjal Kronik, Hemodialisa, Kecemasan.
Program Studi Sarjana Fisioterapi, Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia
Authors: Saputra Afan , Widyastuti Windha , Isytiaroh I 
Published: December 2021

AbstractNausea and vomiting (emesis gravidarum) is a common complaint in the first trimester pregnant women. One of non-pharmacological therapies which are safe to give to pregnant women who experience emesis gravidarum is lemon aromatherapy. This scientific paper aims to investigate the effect of lemon aromatherapy to reduce emesis gravidarum in pregnant women in trimester I. It is a literature review with three articles taken from Google scholar. Emesis gravidarum, lemon therapy, and pregnant women in trimester I are the keywords. These articles are full-text, published in 2018-2019. The analysis result of respondents characteristics from 71 people, most of them (75%) are 20-35 years old, parity 65% of multigravida, gestational age 25% of weeks. Nausea score measurement was measured by RHODES Indeks score. The analysis result of the articles stated there is a significant different before and after intervention. The total score average before applying the intervention was 19.18 and it reduced into 10.63 after the process. It means there is a reduction for about 8.55 after the treatment. The conclusion is applying lemon aromatherapy has effectively reduced emesis gravidarum in pregnant women in trimester I. therefore, nurses were suggested to apply this therapy as an alternative ways to reduce the frequency of nausea.Keywords : emesis gravidarum lemon ; aromatherapy ; pregnant women in trimester I
AbstrakMual muntah (Emesis gravidarum) merupakan keluhan yang sering terjadi pada ibu hamil trimester pertama. Salah satu terapi nonfarmakologi yang aman di berikan pada ibu hamil yang mengalami emesis gravidarum adalah aromaterapi lemon. Karya Tulis Ilmiah ini bertujuan untuk menggambarkan penerapan pengaruh aromaterapi lemon untuk mengurangi emesis gravidarum pada ibu hamil trimester I berdasarkan literature review. Desain Karya Tulis ilmiah ini berupa literature review dengan jumlah artikel tiga yang diambil dari laman jurnal google scolar dengan kata kunci “ emesis gravidarum” “Aromaterapi lemon” dan “ibu hamil trimester I,” berupa artikel fulltext, terbit tahun 2018-2019. Hasil analisa karakteristik responden dari tiga artikel menunjukan jumlah responden 71, sebagian besar 75.0 % umur 20-35 tahun, paritas 65% multigravida, usia kehamilan 25.0 % 9 minggu. Pengukuran skor mual di ukur dengan menggunakan skor Index RHODES. Hasil analisa dari tiga artikel menunjukan jumlah skor rata-rata sebelum intervensi 19,18 setelah intervensi 10,63, terdapat penurunan skor rata-rata setelah dilakukan pemberian aromaterapi lemon sebesar 8,55. Simpulan hasil menunjukan bahwa pemberian aromaterapi lemon efektif menangani emesis gravidarum pada ibu hamil trimester I. Saran bagi petugas kesehatan hendaknya bisa menerapkan aromaterapi lemon sebagai alternatif untuk mengurangi frekuensi mual.Kata Kunci : Emesis Gravidarum ; Aromaterapi Lemon ; Ibu hamil Trimester
Literature Review : Pengaruh Tekhnik Relaksasi Benson Terhadap Nyeri Pada Pasien Post Operasi Benigna Prostat Hyperplasia
Authors: Wildan Andi Muhamad , Wirotomo Tri Sakti , Rofiqoh Siti 
Published: December 2021

AbstractBenign Prostatic Hyperplasia (BPH) is a progressive enlargement of the prostate gland that can be treated surgery, As a result of the surgery, the patient will usually feel pain. To overcome it, Benson’s relaxation technique could be applied. This relaxation is an action to free mentally and physically from tension and stress so that it can increase tolerance to pain. This study aims to examine the effect of Benson’s relaxation technique on pain in patients with postoperative benign prostate hyperplasia. Since it is a literature review, it has reviewed three articles taken from Google scholar with Benson’s relaxation, pain, and postoperative BPH as the keywords. Those articles are full-text, published in 2010-2020. The result stated the average vaule of pain scalee was 6,24 before the treatment and it reduced into 2,07 after it, with the p-value 0,000. It proved the therapy has effectively reduced oain in patients with postoperative benign prostate hyperplasia. Thus, nurses suggested applying this therapy as an alternative to reduce the problem.Keywords: Benson’s relaxation, pain, postoperative benign prostate hyperplasia
AbstrakBenigna Prostat Hyperplasia (BPH) adalah pembesaran progresif dari kelenjar prostat yang dapat diatasi dengan tindakan pembedahan. Akibat dari pembedahan dapat menimbulkan nyeri. Pananganan nyeri salah satunya dengan relaksasi benson. Relaksasi Benson merupakan suatu tindakan untuk membebaskan mental dan fisik dari ketegangan dan stress sehingga dapat meningkatkan toleransi terhadap nyeri. Penelitian ini bertujuan untuk menggambarkan pengaruh teknik relaksasi benson terhadap penurunan nyeri post operasi BPH berdasarkan literature review. Desain karya tulis ilmiah berupa literature review dengan jumlah tiga artikel yang diambil dari laman google scholar dengan kata kunci “relaksasi benson, nyeri, post operasi BPH,” berupa artikel fulltex, terbit tahun 2010-2020. Hasil dari tiga artikel menujukkan nilai rata-rata skala nyeri sebelum intervensi 6,24 setelah intervensi 2,07 dengan p-value 0,000. Simpulan Terapi Relaksasi Benson efektif untuk menurunkan nyeri pasien post operasi BPH. Saran kepada perawat diharapkan dapat memberikan Teknik Relaksasi Benson sebagai alternatif untuk menurunkan nyeri pada pasien post operasi BPH.Kata kunci: Relaksasi Benson, Nyeri, Post Operasi BPH.
Gambaran Peningkatan Kemampuan Fungsional Pada Penderita Osteoarthritis Lutut Setelah Diberikan Kinesiotaping : Literature Review
Authors: Ayu Rosadah Arziah Dyah , Aktifah Nurul 
Published: December 2021

AbstractOsteoarthritis of knee is a musculoskeletal disorder caused by inflammation of the knee joint. Inflammation in patients with knee osteoarthritis causes functional disabilitu which affects the patient’s quality of life. Knee osteoarthritis rehabilitation method using kinesiotaping aims to improve functional ability. The study aimed to describe the improvement in functional ability in patients with knee osteoarthritis after giving kinesiotaping. The selection of articles in this study used the PICO mnemonic. Articles were searched throught Google scholar and PT journal. The selection of articles were used inclusion and exclusion criteria. The result show that there was an increase in functional ability in knee osteoarthritis patien giving kinesiotaping. The average of functional ability decrease pretest 55,0 post test 34,5 and degression 18,6. There is an increase in functional ability after giving kinesiotaping in knee osteoarthritis patients. Kinesiotaping can be used as an alternative modality intervention in osteoarthritis pa-tient who experienced decrease in functional ability knee.Keywords: Knee osteoarthritis; kinesiotaping; WOMAC
AbstrakOsteoarthritis pada lutut merupakan gangguan muskuloskeletal yang disebabkan adanya peradangan pada sendi lutut. Peradangan pada pasien osteoarthritis lutut menyebabkan gangguan ketidakmampuan fungsional yang berpengaruh menurunnya kualitas hidup pasien. Metode re-habilitasi osteoarthritis lutut menggunakan kinesiotaping bertujuan untuk peningkatan kemampuan fungsional. Penelitian literature review ini bertujuan untuk mengetahui gambaran peningkatan kemampuan fungsional pada penderita osteoarthritis lutut setelah diberikan kinesiotaping. Pemilihan artikel pada penelitian ini menggunakan mnemonic PICO. Penulisan artikel ini menggunakan penelusuran literature melalui Google scholar dan PTjournal. Pemilihan artikel menggunakan kriteria inklusi dan kriteria eksklusi. Hasil literature review 5 artikel menunjukan bahwa terdapat peningkatan kemampuan fungsional pada pasien osteoarthritis lutut setelah diberikan kinesiotaping dengan rata-rata pretest 55,0 post test 34,5 dan penurunan 18,6. Terdapat peningkatan kemampuan fungsional setelah diberikan Kinesiotaping pada pasien osteoarthritis lutut. Sebagai dasar tindakan dalam melakukan management fisioterapi pada masalah penurunan kemampuan fungsional pada pasien osteoarthritis lutut, fisioterapi dapat melakukan penanganan dengan menggunakan modalitas Kinesiotaping.Keywords:; Kinesiotaping; osteoarthritis lutut; womac
Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic
Authors: Emorinken Airenakho , Dic-Ijiewere Mercy , Erameh Cyril , Ugheoke Asuwemhe , Agbadaola Oluwaseun , Agbebaku Folasade 
Published: December 2021

IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disorder with a poorly understood aetiology. It predominantly affects females and has a variety of clinical manifestations. In Nigeria, there are limited data on the prevalence and burden of the disease. This study aimed to determine the clinical and laboratory profiles of SLE patients seen in a new rheumatology clinic in South-South Nigeria.Material and methodsThis was a retrospective cross-sectional study conducted over five years (January 2016 to December 2020). The case files of patients that satisfied the diagnosis of SLE were reviewed. The diagnosis was based on the 1997 update of the American College of Rheumatology revised criteria for the classification of SLE. The sociodemographic, clinical, and immunological data were extracted from case records. Data analysis was carried out using IBM SPSS statistics® 2012 version 21.0.ResultsFifty-two patients were diagnosed with SLE, giving a frequency of 4.7%. Forty-seven (90.4%) of the study participants were females, with a female-to-male ratio of 9.4 : 1. The mean age of the study group was 28.42 years. The mean duration of disease before diagnosis was 4.04 months with a range of 1–15 months. The patients had various organ system manifestations, with polyarthritis being the commonest (86.5%). Others included mucocutaneous (78.8%), haematological (69.2%), serositis (40.4%), renal (38.5%), and neurological (25%) manifestations. Antinuclear antibody (ANA) assay and anti-double-stranded DNA were positive in 100% and 69.2% of patients, respectively. All patients were placed on steroids, and 96.2% had hydroxychloroquine. None of the patients were on biologic disease-modifying antirheumatic drugs.ConclusionsThis study’s results are consistent with data from other African countries. To fully understand the burden and epidemiology of SLE in Nigeria, a larger prospective study is needed.
AMOR E POLÍTICA, UMA COMUNIDADE DO DANO: condições precárias em alguma poesia brasileira contemporânea escrita por mulheres
Authors: Magalhães Danielle 
Published: December 2021

Uma das tendências da poesia brasileira contemporânea é a grande presença de poetas mulheres e um dos pontos em comum que une parte dessa produção escrita por mulheres é a condição precária que se determina em vários fatores, como o gênero e a pobreza, por exemplo. Muitas poetas expõem a misoginia, o machismo, o feminicídio, o racismo, a normatividade de gênero e a pobreza em uma abordagem que entrelaça amor e política. Afinando-se com a noção de “precariedade” de Judith Butler, esse artigo pretende mostrar algumas condições de precariedade que fazem dessas poetas uma comunidade pautada no dano, aproximando-se em uma luta lá onde elas aparentemente não se aproximariam. Serão abordadas as poetas Tatiana Nascimento e Tatiana Pequeno.