bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis: A Case Report
Authors: Hosseini Seyedeh Maryam , Abrishami Mojtaba , Barashki Elham , Zamani Ghodsieh 
Published: February 2021

Abstract
Purpose: Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus (EBV)-associated panuveitis and retinitis.Case presentation: A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Ophthalmic examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Initially, the clinical diagnosis of acute retinal necrosis was made based on clinical manifestation; however, the partial response to intravenous and intravitreal antiviral treatment in the left eye and involvement of the right eye resulted in further investigation of masquerade syndromes. Polymerase chain reaction-based analysis of vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite treatment with systemic chemotherapy. Conclusion: There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.
MWCNT-Coated Cotton Yarn Array For Piezoresistive Force and Bending Sensor Applications in Internet of Things Systems
Authors: Jeon Dae-Young , Park So Jeong , Lee Tae Yoon , Kim Gyu-Tae 
Published: February 2021

Abstract
Advanced sensors based on the Internet of Things (IoT) are bringing new technology and productivity paradigms to the era of the fourth industrial revolution. Here, piezoresistive force and bending sensors with good performance (sensitivity ≈ 0.3 kPa−1 and Δnormalized resistance/Δcurvature ≈ 1.5 cm) were fabricated by using perpendicularly aligned multi-walled (MW) carbon nanotube-coated yarn (CNT-CY) arrays, which were obtained from a simple dipping-and-drying method. Verification was performed using a proof-of-concept force sensor matrix with an Arduino open-source microcontroller. In addition, a force sensor combined with real-time data storage in Google Cloud was successfully demonstrated. This work provides important information for the development of a robust, low-cost, and easy-to-manufacture IoT platform with MWCNT-based composites as an active sensing material.
Analytical Quality By Design Methodology For Botanical Raw Material Analysis: A Case Study of Flavonoids in Genkwa Flos
Authors: Kim Min Kyoung , Park Sang Cheol , Park Geonha , Choi Eunjung , Ji Yura , Jang Young Pyo 
Published: February 2021

Abstract
The present study introduces a systematic approach using analytical quality by design (AQbD) methodology for the development of a qualified liquid chromatographic analytical method, which is a challenge in herbal medicinal products due to the intrinsic complex components of botanical sources. The ultra-high-performance liquid chromatography-photodiode array-mass spectrometry (UHPLC-PDA-MS) technique for eleven flavonoids in Genkwa Flos was utilized through the entire analytical processes, from the risk assessment study to the factor screening test, and finally in method optimization employing central composite design (CCD). In this approach, column temperature and mobile solvent slope were found to be critical method parameters (CMPs) and each of the eleven flavonoid peak’s resolution values were used as critical method attributes (CMAs) through data mining conversion formulas. An optimum chromatographic method in the design space was calculated by mathematical and response surface methodology (RSM). A validation study was also performed successfully for apigenin 7-O-glucuronide, apigenin, and genkwanin. In conclusion, the present design-based approach provide a systematic platform that can be effectively applied to ensure pharmaceutically qualified analytical data from complex natural products based botanical drug.
Influence of Spray Parameters on the Thickness, Hardness and Porosity of low-pressure Cold Sprayed WC-Ni Coatings
Authors: Jibran Wania , Hogan James , McDonald André 
Published: February 2021

Abstract
In this study, a 33 full factorial design methodology was used ­­to analyze the effects of spray parameters on the thickness, hardness, and surface porosity of low-pressure cold-sprayed WC-17Ni coatings. Three levels were selected for the spray parameters included in the design which were the powder feed rate (17.1 g/min, 21.1 g/min, and 23.7 g/min), gas temperature (475℃, 500℃, and 525℃), and the nozzle to substrate stand-off distance (3 mm, 5 mm, and 10 mm). It was found that the feed rate was the most significant parameter that affected the coating thickness. The surface porosity was most significantly affected by stand-off distance. The coating hardness was most influenced by the interaction between the feed rate and stand-off distance. An optimization study was then performed to maximize the coating thickness and hardness while minimizing the surface porosity. The optimal spray parameters (OSP) were found to be at a feed rate of 23.7 g/min, 500℃ for the carrier gas temperature, and 10 mm for the stand-off distance. The OSP yielded a coating that was 1.22 ± 0.06 mm thick, with a hardness of 364.5 ± 8.5 HV and porosity of 6.8 ± 0.6%. With a multi-parameter process, the system response is affected by both the variation in the individual parameters and the interaction of the parameters with each other. It was also concluded that the interaction between the parameters significantly affected the coating hardness. These results suggest that variation of the selected parameters produce statistically significant effects on the coating quality of WC-17Ni coatings using a low-pressure cold spray system.
FTIR, Optical, Electrical and Magnetic properties of Sm+3 doped Mg Nano Ferrites by Citrate-Gel Auto combustion method
Authors: Nakiraboina Venkatesh , Goud Shyam sunder , Nama Hari Kumar , Ravinder D , P Veera Somaiah 
Published: February 2021

Abstract
Sm, doped Mg nano ferrites with composition Mg Sm x Fe2 − x O4 (where X = 0.000, 0.025, 0.050, 0.075,0.1) were synthesized by citrate-gel auto-combustion method. The Samples were analyzed through various experimental techniques. The structural confirmation was done with the basic characterization techniques such as XRD (X-ray Powder Diffraction) and Fourier Transform Infrared (FTIR) spectroscopic analysis. To study the optical absorption behavior of the prepared ferrites, UV-visible spectral analysis was carried out. XRD analysis established the formation of single-phase cubic spinel structure of the materials. FTIR spectra has shown two absorption peaks that are characteristic of spinel nano ferrites. The dc electrical resistivities of the Sm doped Mg nano ferrites were studied by using two probe method at the temperature range of 200–500 °C. A plot of log (σT) vs inverse of temperature yields a curve which reveals a semiconducting nature of prepared nano ferrites. The Thermo Electric Power (TEP) studies of prepared samples carried out at high temperature (573K). The values of the Seebeck coefficient and curie temperature of Sm doped Mg nano ferrites were observed. The magnetization measurements were carried out by using Vibrating Sample Magnetometer (VSM).
Expanded Hemodialysis as Effective Alternative to On-Line Hemodiafiltration: A Randomized Mid-Term Clinical Trial
Authors: Hadad-Arrascue Fernando , Nilsson Lars-Göran , Rivera Angela S , Bernardo Angelito A , Romero Juan B Cabezuelo 
Published: February 2021

Abstract
BACKGROUND.
Hemodiafiltration (HDF) enhances middle molecule (MM) removal by convection and shows survival benefit compared to high-flux hemodialysis. Expanded hemodialysis (HDx), a novel therapy that effectively clears MM, uses medium cut-off (MCO) membrane without need for replacement fluid. We aimed to compare HDx to HDF prospectively in an open randomized controlled clinical study.
METHODS.
In a 24-week prospective study, HDF patients (age 18–80 yrs; on HDF > 3 months) were randomized to switch to HDx (N = 21) or continue HDF (N = 22). Pre- to post-dialysis reduction ratios (RR) and changes in pre-dialysis levels over time were evaluated for MMs and other clinical biomarkers. Use of erythropoiesis-stimulating agents (ESAs) were evaluated.
RESULTS.
HDx showed greater RR for YKL-40 while RR appeared similar between groups for beta2-microglobulin, FGF-23, and free light chains. Intra-dialytic changes in inflammatory biomarkers (IL-6, CRP, PTX3) did not differ between therapies. Changes from baseline to 12 and 24 weeks did not differ between groups for MMs, inflammatory markers, albumin, fibrinogen, hemoglobin, PTH, and phosphorus. Usage of erythropoiesis-stimulating agents tended to decrease in HDx arm while remaining stable in HDF arm.
CONCLUSIONS.
HDx showed equivalent removal of MMs versus high volume HDF. Greater RR of YKL-40, predictor of cardiovascular mortality in HD, was noted in HDx group. HDx appeared safe with similar clinical effectiveness as HDF. With fewer requirements and resource needs, HDx provides an attractive alternative to HDF. Further clinical studies are needed to confirm our results.
TRIAL REGISTRATION.
The study was registered as NCT03499691
Topological Analysis of Interaction Patterns in Cancer-Specific Gene Regulatory Network: Persistent Homology Approach
Authors: Masoomy Hosein , Askari Behrouz , Tajik Samin , Rizi Abbas K. , Jafari G. Reza 
Published: February 2021

Abstract
In this study, we investigated cancer cellular networks in the context of gene interactions and their associated patterns in order to recognize the structural features underlying this disease. We aim to propose that the quest of understanding cancer takes us beyond pairwise interactions between genes to a higher-order construction. We characterize the most prominent network deviations in the gene interaction patterns between cancer and normal samples that contribute to the complexity of this disease. What we hope is that through understanding these interaction patterns we will notice a deeper structure in the cancer network. This study uncovers the significant deviations that topological features in cancerous cells show from the healthy one, where the last stage of filtration confirms the importance of 1-dimensional holes (topological loops) in cancerous cells and 2-dimensional holes (topological voids) in healthy cells. In the small threshold region, the drop in the number of connected components of the cancer network, along with the rise in the number of loops and voids, all occurring at some smaller weight values compared to the normal case, reveals the cancerous network tendency to certain pathways.
Ranking Epilepsy Risk Factors Using Machine Learning
Authors: Skiba Iaroslav , Kopanitsa Georgy , Metsker Oleg , Polushin Alexey , Yanishevskiy Stanislav 
Published: February 2021

Abstract
BackgroundMachine learning methods to predict the risk of epilepsy, including vascular epilepsy, in oncohematological patients are currently considered promising. These methods are actively used in epileptology to predict pharmacoresistant epilepsy, surgical treatment outcomes, to determine the epileptogenic zone and functional neural systems in patients with epilepsy, as well as to develop new approaches to classification and perform other tasks. This paper presents the results of applying machine learning to analyzing data and developing models of epilepsy in vascular and oncohematological patients. MethodsWe analyzed the hospital database of the V.A. Almazov Scientific Research Center of the Ministry of Health of Russia. The study included 66723 treatment episodes of patients with vascular diseases (I10-I15,I61-I69,I20-I25) and 16383 episodes with malignant neoplasms of lymphoid, hematopoietic, and related tissues (C81-C96 according to ICD-10) for the period from 2010 to 2020. ResultsData analysis and model calculations indicate that the best result was shown by gradient boosting with mean accuracy cross-validation score = 0.96. f1-score = 98, weighted avg precision = 93, recall = 96, f1-score = 94. The highest correlation coefficient for G40 was achieved with fibrillation, hypertension, stenosis or occlusion of the precerebral arteries (0.16), cerebral sinus thrombosis (0.089), arterial hypertension (0.17), age (0.03), non-traumatic intracranial hemorrhage (0.07), atrial fibrillation (0.05), delta absolute neutrophil count (0.05), platelet count at discharge (0.04), transfusion volume for stem cell transplantation (0.023). ConclusionFrom the clinical point of view, the identified differences in the importance of predictors in a broader patient model are consistent with a practical algorithm for organic brain damage. Atrial fibrillation is one of the leading factors in the development of both ischemic and hemorrhagic strokes. At the same time, brain infarction can be accompanied both by the development of epileptic seizures in the acute period and by unprovoked epileptic seizures and development of epilepsy in the early recovery and in a longer period. In addition, microembolism of the left heart chambers can lead to multiple microfocal lesions of the brain, which is considered to be one of the pathogenetic aspects of epilepsy in elderly patients.
Reliability of Visual Assessment for Diagnosis of Neonatal Jaundice Among Neonates of Black Descent: A Cross-Sectional Study From Tanzania.
Authors: Dionis Ikunda , Chillo Omary , Bwire George M , Kilonzi Manase , Ulomi Calvin , Balandya Emmanuel 
Published: February 2021

Abstract
Background: Jaundice is common among neonates and if untreated can lead to kernicterus. Diagnosing of jaundice in neonates using Kramer’s method (visual assessment) is considered user friendly in resource limited areas. However, there are conflicting finding on reliability of the Kramer’s method in diagnosis of neonatal jaundice (NJ) particularly of black descent. Therefore, this study aimed to determine diagnostic accuracy of Kramer’s method in comparison with total serum bilirubin (TSB) test in diagnosis of NJ among neonates of black descent in Tanzania. Methods: A cross-sectional study was conducted between June and July 2020 at Muhimbili National Hospital (MNH) in Dar es Salaam Tanzania. A total of 315 neonates were recruited consecutively. In each neonates’ jaundice was assessed by using Kramer’s method and TSB test. A 2 X 2 table was created for determination of sensitivity, specificity, positive predictive values (PPV), negative predictive value (NPV), positive and negative likelihood ratios (+LR/-LR) and diagnostic accuracy (effectiveness). Cohen kappa (κ) was used to analyze the agreement between Kramer’s method and TSB. Association between independent variables and presence of jaundice were assessed using chi-square test and the p ˂ 0.05 was considered to be statistical significance. Results: The prevalence of NJ was 49.8% by Kramer’s method and 63.5% by TSB. The Sensitivity, Specificity, PPV, and NPV of the Kramer’s method were 70.5%, 86.1%, 88.8%, and 62.6%, respectively. The +LR and –LR were 5.07 and 0.34 respectively. The diagnostic accuracy of the Kramer’s method was 76.1%. There was a moderate agreement between Kramer’s method and TSB results (κ= 0.524, P˂0.001). No significance relationship between the independent variables and presence of NJ. Conclusion: Kramer’s method was found to be inefficient in detecting NJ among neonates of black descent. However, it can be used as a predictor of NJ and whenever available invasive techniques should be applied.
Cascading Effects of Moth Outbreaks on Subarctic Soil Food Webs
Authors: Calderón-Sanou Irene , Münkemüller Tamara , Zinger Lucie , Schimann Heidy , Yoccoz Nigel Gilles , Gielly Ludovic , Foulquier Arnaud , Hedde Mickael , Ohlmann Marc , Roy Mélanie , Si-Moussi Sara , Thuiller Wilfried 
Published: February 2021

Abstract
The increasing severity and frequency of natural disturbances requires a better understanding of their effects on all compartments of biodiversity. In Northern Fennoscandia, recent large-scale moth outbreaks have led to an abrupt change in plant communities from birch forests dominated by dwarf shrubs to grass-dominated systems. However, the indirect effects on the belowground compartment remained unclear. Here, we combined eDNA survey of multiple trophic groups with network analyses to demonstrate that moth defoliation has far-reaching consequences on soil food webs. Following this disturbance, diversity and relative abundance of certain trophic groups declined (e.g. ectomycorrhizal fungi) while many others profited (e.g. bacterivores, omnivores) making soil food webs more diverse and structurally different. Overall, the direct and indirect consequences of moth outbreaks increased belowground diversity at different trophic levels. Our results highlight that a holistic view of ecosystems improves our understanding of cascading effects of major disturbances on soil food webs.
The Systemic-Immune-Inflammation Index Predicts the Recurrence of Atrial Fibrillation After Cryomaze Concomitant With Mitral Valve Surgery
Authors: Luo Yu , Zhang Jian , Liu Tao , Yin Zongtao , Jin Yan , Han Jinsong , Wang Huishan 
Published: February 2021

Abstract
Background and aims:
Inflammation plays a key role in the initiation and progression of atrial fibrillation (AF). The systemic inflammation indexes are easily evaluated and predict AF development. However, it’s role in prediction of recurrence of AF is unknown. We aim to explore the association between the systemic inflammation indexes and recurrence of AF in patients underwent cryoablation (CryoMaze) concomitant with mitral valve surgery.
Methods
We examined systemic inflammation indexes during perioperative period in 122 patients between 2015 to 2018. Systemic inflammation indexes were developed by systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocytes to monocytes ratio (LMR). Univariate and multivariate analyses were performed to examine the association of each markers with recurrence of AF.
Results
Of the 122 patients included in this study, 22 patients (18%) experienced AF recurrence after CryoMaze concomitant with mitral valve surgery. There is no significant difference between each systemic inflammation indexes before surgery and recurrence of AF. In univariate analysis, MLR after surgery 3 days, PLR, MPLR, NLR, SII after surgery 7 days were able to predict recurrence of AF. In multivariate analyses, SII ≥ 1696 independently predicted recurrence (OR, 3.719; 95% CI, 1.417–9.760). Interestingly, baseline SII showed no significant in prediction of recurrence. It was sharply elevated after surgery and dropped slowly. In patients of recurrence, SII after 7days of surgery increased again.
Conclusions
The raised SII again was associated with an increased risk of the postoperative recurrence of AF and independently predicted the late recurrence of AF after CryoMaze concomitant with mitral valve surgery.
Transcriptome analysis and differentially expressed gene screening for hypoxic-ischemic brain damage in rats treated with acupuncture
Authors: Jiang Xin , Qin Weixun , Wu Junyan , Xiao Jiang , Zhong Yue , Yuan Chao , Yuan Qing 
Published: February 2021

Abstract
Hypoxic-ischemic brain damage (HIBD) is one of the most common critical diseases in neonates with high mortality and disability rates. The latest research showed that long non-coding RNAs(lncRNA) played an important role in the development of HIBD. Recently, acupuncture therapy has been found to be effective in the treatment of HIBD. However, the mechanism of lncRNA in acupuncture treatment of HIBD is still unclear. In this study, we investigated the role of lncRNA in acupuncture treatment of HIBD in detail. We demonstrated behavioral performance similar to cognitive deficits in HIBD rat models in the new object recognition experiment and pathological lesion of the prefrontal cortex in nissl staining. Acupuncture treatments at acupoints DU24 and GB13 was proved to be effective in alleviating behavioral deficits and brain injury. A whole transcriptome analysis was applied to investigate transcriptome changes caused by acupuncture in PFC of HIBD rats. A total of 48 mRNAs and 65 lncRNAs was identified relate to acupuncture group and model group. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analysis, we found several lncRNAs and their target mRNAs were related to PI3K-Akt signaling pathway, TNF signaling pathway and NOD-like receptor signaling pathway, etc. The results of our research may provide new perspectives on the mechanism of acupuncture and affect the diagnosis and treatment of HIBD.
Association between the nonHDLc/HDLc ratio and 30-day mortality for patients with sepsis: a retrospective observational cohort study based on a large multicentre critical care database
Authors: Chang Le , Chen Xinglin , Ye Zhengxu 
Published: February 2021

Abstract
Background: Dyslipidemia contributes to the development and progression of cardiovascular disease. The objective of this study was to investigate the association between the non-high-density lipoprotein-cholesterol-to-high-density lipoprotein-cholesterol (non-HDL-c/HDL-c) ratio and mortality for patients with sepsis.Methods: Using data from the eICU Collaborative Research Database (eICU-CRD) with high granularity data for over 200,000 admissions to ICUs monitored by eICU Programs across the United States. We identified 1680 patients with sepsis. All-cause mortality within 30-days after the date of visit to the ICU. We estimated the risk of mortality using multivariable logistic-regression model.Result: There were 115 deaths (6.85%). The probability of mortality decreased when the nonHDLc/HDLc ratio lower than the turning point ( <3.58) with a adjusted odds ratio (OR) of 0.75 (95% CI: 0.61–0.94, P=0.011) for every 1 increment of nonHDLc/HDLc ratio. With the per-SD increase in the nonHDLc/HDLc ratio, the OR for mortality was 0.36 (95% CI: 0.16–0.79, P=0.011) when nonHDLc/HDLc ratio was <3.58, while the OR was 1.56 (95% CI: 1.29–1.88, P<0.001) when nonHDLc/HDLc ratio was ≥ 3.58.Conclusion: Higher nonHDLc/HDLc ratio, even at a low level, was associated with a higher risk of 30-day mortality for patients with sepsis. The probability of mortality rose rapidly when the nonHDLc/HDLc ratio higher than the turning point (may at 3.58).
ABHD6 inhibition rescues a sex-dependent deficit in motor coordination in the HdhQ200/200 mouse model of Huntington’s disease
Authors: Cao Jessica K. , Viray Katie , Shin Myungsun , Hsu Ku-Lung , Mackie Ken , Westenbroek Ruth , Stella Nephi 
Published: February 2021

Abstract
Huntington’s Disease is associated with motor behavior deficits that current therapeutics do not alleviate. This pilot study tested if pharmacological inhibition of a/b-hydrolase domain containing 6 (ABHD6), a multifunctional enzyme expressed in the striatum, rescues behavioral deficits in HdhQ200/200 mice. Previous work has shown that this model exhibits a reduction in spontaneous locomotion and motor coordination at 8 and 10 months of age, with a more severe phenotype in female mice. Semi-quantitative immunohistochemistry analysis indicated no change in striatal ABHD6 expression at 8 months of age, but a 40% reduction by 10 months in female HdhQ200/200 mice compared to female wild-type (WT) littermates. At 8 months of age, acute ABHD6 inhibition selectively rescued motor coordination deficits in female HdhQ200/200 mice without affecting WT performance. ABHD6 inhibition did not impact spontaneous locomotion, grip strength or overall weight in either group, showing that effects were specific to motor coordination. At 10 months of age, semi-chronic ABHD6 inhibition by osmotic pump delivery also rescued motor coordination deficits in female HdhQ200/200 mice without affecting female WT littermates. Our preliminary study suggests that ABHD6 inhibition selectively improves motor performance in female HdhQ200/200 mice.