bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planetary Biosecurity: Applying Invasion Science to Prevent Biological Contamination from Space Travel
Authors: Ricciardi Anthony , Cassey Phillip , Leuko Stefan , Woolnough Andrew P 
Published: October 2021

Abstract
As plans for space exploration and commercial use expand rapidly, biosecurity measures and risk assessments that inform them must adapt. Sophisticated protocols are required to prevent biological contamination of extraterrestrial environments from Earth and vice versa. Such protocols should be informed by research on biological invasions—human-assisted spread of organisms into novel environments—which has revealed, inter alia, that (1) invasion risk is driven by the timing and frequency of introduction events, whose control requires addressing the least secure human activities associated with organismal transport; (2) invasions and their impacts are difficult to predict, because these phenomena are governed by context dependencies involving traits of the organism and the receiving environment; and (3) early detection and rapid response are crucial for prevention but undermined by taxonomic methods that fail to recognize what is “alien” versus what is native. Collaboration among astrobiologists, invasion biologists, and policymakers could greatly enhance planetary biosecurity protocols.
EEG Frequency Tagging Reveals the Integration of Form and Motion Cues into the Perception of Group Movement
Authors: Cracco Emiel , Lee Haeeun , van Belle Goedele , Quenon Lisa , Haggard Patrick , Rossion Bruno , Orgs Guido 
Published: October 2021

Abstract
The human brain has dedicated mechanisms for processing other people’s movements. Previous research has revealed how these mechanisms contribute to perceiving the movements of individuals but has left open how we perceive groups of people moving together. Across three experiments, we test whether movement perception depends on the spatiotemporal relationships among the movements of multiple agents. In Experiment 1, we combine EEG frequency tagging with apparent human motion and show that posture and movement perception can be dissociated at harmonically related frequencies of stimulus presentation. We then show that movement but not posture processing is enhanced when observing multiple agents move in synchrony. Movement processing was strongest for fluently moving synchronous groups (Experiment 2) and was perturbed by inversion (Experiment 3). Our findings suggest that processing group movement relies on binding body postures into movements and individual movements into groups. Enhanced perceptual processing of movement synchrony may form the basis for higher order social phenomena such as group alignment and its social consequences.
Deep transfer learning for cerebral cortex using area-preserving geometry mapping
Authors: Gao Kai , Fan Zhipeng , Su Jianpo , Zeng Ling-Li , Shen Hui , Zhu Jubo , Hu Dewen 
Published: October 2021

Abstract
Limited sample size hinders the application of deep learning in brain image analysis, and transfer learning is a possible solution. However, most pretrained models are 2D based and cannot be applied directly to 3D brain images. In this study, we propose a novel framework to apply 2D pretrained models to 3D brain images by projecting surface-based cortical morphometry into planar images using computational geometry mapping. Firstly, 3D cortical meshes are reconstructed from magnetic resonance imaging (MRI) using FreeSurfer and projected into 2D planar meshes with topological preservation based on area-preserving geometry mapping. Then, 2D deep models pretrained on ImageNet are adopted and fine-tuned for cortical image classification on morphometric shape metrics. We apply the framework to sex classification on the Human Connectome Project dataset and autism spectrum disorder (ASD) classification on the Autism Brain Imaging Data Exchange dataset. Moreover, a 2-stage transfer learning strategy is suggested to boost the ASD classification performance by using the sex classification as an intermediate task. Our framework brings significant improvement in sex classification and ASD classification with transfer learning. In summary, the proposed framework builds a bridge between 3D cortical data and 2D models, making 2D pretrained models available for brain image analysis in cognitive and psychiatric neuroscience.
Minimally Invasive Postmortem Intestinal Tissue Sampling in Malnourished and Acutely Ill Children Is Feasible and Informative
Authors: Feutz Erika , Voskuijl Wieger , Finch Peter J , Liu Ta-Chiang , Bandsma Robert H J , Tarr Phillip I , Moxon Christopher Alan , VanBuskirk Kelley , Lawrence Sarah , Umutesi Grace , Tickell Kirkby D , Berkley James A , Walson Judd L , Kamiza Steve , Denno Donna M 
Published: October 2021

Abstract

Background
Intestinal disorders such as environmental enteric dysfunction (EED) are prevalent in low- and middle-income countries (LMICs) and important contributors to childhood undernutrition and mortality. Autopsies are rarely performed in LMICs but minimally invasive tissue sampling is increasingly deployed as a more feasible and acceptable procedure, although protocols have been devoid of intestinal sampling to date. We sought to determine (1) the feasibility of postmortem intestinal sampling, (2) whether autolysis precludes enteric biopsies’ utility, and (3) histopathologic features among children who died during hospitalization with acute illness or undernutrition.

Methods
Transabdominal needle and endoscopic forceps upper and lower intestinal sampling were conducted among children aged 1 week to 59 months who died while hospitalized in Blantyre, Malawi. Autolysis ratings were determined for each hematoxylin and eosin slide, and upper and lower intestinal scoring systems were adapted to assess histopathologic features and their severity.

Results
Endoscopic and transabdominal sampling procedures were attempted in 28 and 14 cases, respectively, with &gt;90% success obtaining targeted tissue. Varying degrees of autolysis were present in all samples and precluded histopathologic scoring of 6% of 122 biopsies. Greater autolysis in duodenal samples was seen with longer postmortem interval (Beta = 0.06, 95% confidence interval, 0.02–0.11). Histopathologic features identified included duodenal Paneth and goblet cell depletion. Acute inflammation was absent but chronic inflammation was prevalent in both upper and lower enteric samples. Severe chronic rectal inflammation was identified in children as young as 5.5 weeks.

Conclusions
Minimally invasive postmortem intestinal sampling is feasible and identifies histopathology that can inform mortality contributors.
A Nonprofit Drug Development Model Is Part of the Antimicrobial Resistance (AMR) Solution
Authors: Piddock Laura J V , Paccaud Jean-Pierre , O’Brien Seamus , Childs Michelle , Malpani Rohit , Balasegaram Manica 
Published: October 2021

Abstract
Antibiotics underpin modern medicine and are critical for pandemic preparedness. Push funding has revitalized the preclinical antimicrobial resistance (AMR) pipeline and government funding via CARB-X and BARDA, as well as private sector–led investment via the AMR Action Fund, will help several new antibiotics obtain regulatory approval. Nevertheless, revenues generated by new antibiotics are not considered sufficiently profitable by commercial developers to address unmet need. The question remains: Who could viably fund development and secure global equitable access for new antibiotics? Public health need should be the primary driver for antibiotic development. Improved prioritization and government oversight by funders who allocate public resources are a needed first step. In this framework, nonprofit research and development organizations, with support from public funders, and unconstrained by commercial profitability requirements are well positioned to work with public and private actors to viably provide new antibiotics to all in need.
Progressive Development of Cefiderocol Resistance in Escherichia coli During Therapy is Associated With an Increase in blaNDM-5 Copy Number and Gene Expression
Authors: Simner Patricia J , Mostafa Heba H , Bergman Yehudit , Ante Michael , Tekle Tsigereda , Adebayo Ayomikun , Beisken Stephan , Dzintars Kathryn , Tamma Pranita D 
Published: October 2021

Abstract

Background
As cefiderocol is increasingly being prescribed in clinical practice, it is critical that we understand key mechanisms contributing to acquired resistance to this agent.

Methods
We describe a patient with acute lymphoblastic leukemia and a New Delhi metallo-ß-lactamase (NDM)–5–producing Escherichia coli intra-abdominal infection in whom resistance to cefiderocol evolved approximately 2 weeks after the start of treatment. Through whole-genome sequencing (WGS), messenger RNA expression studies, and ethylenediaminetetraacetic acid inhibition analysis, we investigated the role of increased NDM-5 production and genetic mutations contributing to the development of cefiderocol resistance, using 5 sequential clinical E. coli isolates obtained from the patient.

Results
In all 5 isolates, blaNDM-5 genes were identified. The minimum inhibitory concentrations for cefiderocol were 2, 4, and &gt;32 μg/mL for isolates 1–2, 3, and 4–5, respectively. WGS showed that isolates 1–3 contained a single copy of the blaNDM-5 gene, whereas isolates 4 and 5 had 5 and 10 copies of the blaNDM-5 gene, respectively, on an IncFIA/FIB/IncFII plasmid. These findings were correlated with those of blaNDM-5 messenger RNA expression analysis, in which isolates 4 and 5 expressed blaNDM-5 1.7- and 2.8-fold, respectively, compared to, isolate 1. Synergy testing with the combination of ceftazidime-avibactam and aztreonam demonstrated expansion of the zone of inhibition between the disks for all isolates. The patient was successfully treated with this combination and remained infection free 1 year later.

Conclusions
The findings in our patient suggest that increased copy numbers of blaNDM genes through translocation events are used by Enterobacterales to evade cefiderocol-mediated cell death. The frequency of increased blaNDM-5 expression in contributing to cefiderocol resistance needs investigation.
Banking on the Confucian Clan: Why China Developed Financial Markets so Late
Authors: Chen Zhiwu , Ma Chicheng , Sinclair Andrew J 
Published: October 2021

AbstractOver the past millennium, China has relied on the Confucian clan to achieve interpersonal cooperation, focusing on kinship and neglecting the development of impersonal institutions needed for external finance. In this paper, we test the hypothesis that the Confucian clan and financial markets are competing substitutes. Using the large cross-regional variation in the adoption of modern banks, we find that regions with historically stronger Confucian clans established significantly fewer modern banks in the four decades following the founding of China's first modern bank in 1897. Our evidence also shows that the clan continues to limit China's financial development today.
The impact of dissection membrane motility on mid-term aortic remodelling after thoracic endovascular repair
Authors: Lescan Mario , Mustafi Migdat , Wilhelm Viktoria , Keller Marius , Schlensak Christian , Rosenberger Peter , Magunia Harry 
Published: October 2021

Abstract

OBJECTIVES
The aim of this study was to assess preoperative dissection flap motility and to evaluate its impact on the aortic remodelling and the development of distal stent-induced new entry after thoracic endovascular aneurysm repair (TEVAR)/frozen elephant trunk (FET).

METHODS
Patients with primary or residual type B dissections were included in a retrospective study with transoesophageal echocardiography analysis of the preoperative dissection flap motility assessed by the true lumen (TL) strain. Three-dimensional computing tomography centreline reconstructions before TEVAR/FET and during the follow-up were conducted to measure aortic remodelling: false lumen thrombosis, TL expansion and aortic diameters at 10 and 20 cm downstream the left subclavian artery, at the coeliac trunk and in the infrarenal aorta. All continuous variables are reported as median with first and third quartiles.

RESULTS
Fifty-six consecutive patients were treated with TEVAR (n = 45) or FET (n = 11) in the acute (n = 16), subacute (n = 16) and chronic (n = 24) dissection phase. At a median follow-up of 6 (3–12) months, they showed a favourable TL expansion in the descending aorta, significantly higher in the acute [+9 mm (5–12); P &lt; 0.001] and subacute groups [+5 mm (3–8); P = 0.039] than in the chronic group [+2 mm (0–5)]. The dissection flap motility parameter TL strain was superior in the acute (P = 0.006) and subacute (P = 0.035) groups in comparison to the chronic group. The motile flap [TL strain &gt;22.5% (median)] was associated with a higher TL expansion rate in the thoracic aorta (P = 0.009) and a comparable distal stent-induced new entry incidence (overall: 16%) in comparison to the immobile flap (P = 0.89).

CONCLUSIONS
The intraoperative assessment and the inclusion of the dissection flap motility parameters in the decision-making during TEVAR/FET may refine the distal endograft sizing for an improved remodelling of the TL.
Exploring L2 teacher motivation to participate in a theatre festival
Authors: Bačová Daniela 
Published: October 2021

Abstract
Teacher motivation is a key component for increasing teachers’ commitment to their professionalism and the quality of their teaching. This paper provides insight into L2 teacher motivation in the context of their sustained engagement with a theatre festival for schools. Drawing on self-determination theory, it investigates how this extracurricular activity enables the teachers to fulfil their individual and professional needs. The findings from eight semi-structured interviews of Slovak ELT teachers suggest the festival offers them a space for satisfaction of their needs for autonomy, competence, and relatedness in the long term. The festival enables them to pursue their own intrinsic appreciation of arts and theatre that is then shared with their pupils. Teachers appreciate the co-creative process during the rehearsals, which enhances learners’ intrinsic and instrumental value of learning English. They believe the festival fosters their learners’ language development in a holistic way, enhancing their emotional and social skills.
How does social support shape the association between depressive symptoms and labour market participation: a four-way decomposition
Authors: Veldman Karin , Pingel Ronnie , Hallqvist Johan , G. Bean Christopher , Hammarström Anne 
Published: October 2021

Abstract

Background
Little is known about factors that may explain the association between depressive symptoms and poor labour market participation (LMP). The aim of this study is to examine the mediation and interaction effects of social support on the association between depressive symptoms and LMP.

Methods
Data were used from 985 participants (91% of the initial cohort) of the Northern Swedish Cohort, a longitudinal study of Swedish participants followed from adolescence throughout adulthood. Depressive symptoms were measured at age 16, social support at age 21 and LMP from age 30 to 43. Poor LMP was defined as being unemployed for a total of 6 months or more between the ages of 30 and 43. A four-way decomposition approach was applied to identify direct, mediation and interaction effects, together and separately.

Results
Both depressive symptoms during adolescence and social support at young adulthood were associated with poor LMP [odds ratio (OR) = 1.70, 95% confidence interval (CI) 1.17–2.47 and OR = 2.56, 95% CI 1.78-3.68 respectively]. The association between depressive symptoms and poor LMP was partially mediated by a lack of social support. No interaction effect of a lack of social support was found.

Conclusion
The results suggest that depressive symptoms influence not only later LMP but also the intermediary level of social support, and in turn influencing later LMP. Recommendations for public health are to detect and treat depressive symptoms at an early stage and to focus on the development of social skills, facilitating the increased availability of social support, thereby improving future LMP.
Long-term intrathecal administration of morphine vs. baclofen: Differences in CSF glycoconjugate profiles using multiglycomics
Authors: Moh Edward S X , Nishtala Krishnatej , Iqbal Sameera , Staikopoulos Vasiliki , Kapur Dilip , Hutchinson Mark R , Packer Nicolle H 
Published: October 2021

Abstract
Opioid use for treatment of persistent pain has increased dramatically over the past two decades, but it has not resulted in improved pain management outcomes. To understand the molecular mechanisms of opioids, molecular signatures that arise from opioid exposure are often sought after, using various analytical methods. In this study, we performed proteomics, and multiglycomics via sequential analysis of polysialic acids, glycosaminoglycans, N-glycans and O-glycans, using the same cerebral spinal fluid (CSF) sample from patients that had long-term (&gt;2 years), intrathecal morphine or baclofen administered via an indwelling pump. Proteomics and N-glycomics signatures between the two treatment groups were highly conserved, while significant differences were observed in polysialic acid, heparan sulfate glycosaminoglycan and O-glycan profiles between the two treatment groups. This represents the first study to investigate the potential relationships between diverse CSF conjugated glycans and long-term intrathecal drug exposure. The unique changes, observed by a sequential analytical workflow, reflect previously undescribed molecular effects of opioid administration and pain management.
Post-traumatic chest wall lipoma in a violinist: fact or fiction?
Authors: Erginöz Ergin , Çavuş Gökçe Hande , Çarkman Sinan 
Published: October 2021

Abstract
Lipomas are benign soft tissue tumours that can occur anywhere on the body and are rarely encountered on the chest. The pathophysiology between soft tissue trauma and lipoma development is not fully understood, and various theories have been presented. We present the case of a violinist with a 40-year occupational history who presented with swelling of the left upper chest wall. The microscopic sample of the resected lipoma showed inflammatory cells with fat necrosis, which are features thought to be involved in the development of a lipoma following soft tissue trauma.
Diffusion of dermatological irritant in drying laundered cloth
Authors: Broadbridge P , Tilley B S 
Published: October 2021

AbstractSodium dodecyl sulphate (SDS), a commonly used laundry surfactant, has been known to cause some damage to epithelial cells in skin. Further, independent experiments have shown that a single laundry wash with rinsing leaves a residue of around 10% of the chemicals used in a wash cycle. A realistic nonlinear system of partial differential equations is developed for coupled water and solute transport through a drying porous medium when the solute has a mobile state (monomers) as well as an immobile state (micelles). An accurate finite difference scheme is developed and tested against known exact solutions of the nonlinear porous medium equation for transport of water and against known conservation laws. It shows that at the end of atmosphere-controlled stage 1 of drying when little water remains, the concentration of SDS near the drying surface, where it may contact skin, is commonly an order of magnitude higher than its initial value. The problem is exacerbated by successive regular wash cycles and by higher evaporation rates in electronic dryers. The numerical solutions show the partitioning between the two phases of SDS.
Toward a Communitarian Theory of Aesthetic Value
Authors: Riggle Nick 
Published: October 2021

AbstractOur paradigms of aesthetic value condition the philosophical questions we pose and hope to answer about it. Theories of aesthetic value are typically individualistic, in the sense that the paradigms they are designed to capture, and the questions to which they are offered as answers, center the individual’s engagement with aesthetic value. Here I offer some considerations that suggest that such individualism is a mistake and sketch a communitarian way of posing and answering questions about the nature of aesthetic value.
Anticholinergic medication use in elderly people living with HIV and self-reported neurocognitive impairment: a prospective cohort study
Authors: Jakeman Bernadette , Scherrer Alexandra , Battegay Manuel , Gunthard Huldrych F. , Hachfeld Anna , Calmy Alexandra , Schmid Patrick , Bernasconi Enos , Cavassini Matthias , Marzolini Catia 
Published: October 2021

Abstract

Background
Anticholinergic (ACH) medications have been associated with neurocognitive impairment, particularly in the elderly. This study determined prospectively the prevalence of prescribed ACH medications and their association with self-reported neurocognitive impairment (SRNI) in elderly people living with HIV (PLWH) of the Swiss HIV Cohort Study (SHCS).

Methods
A literature review was performed to identify ACH medications, which were scored 0 to 3 (higher score indicating more ACH burden). Prescriptions were reviewed in July 2019 for all SHCS participants ≥65 years old to assess the prevalence of ACH medications. Association between ACH burden and neurocognitive impairment was evaluated using the SHCS SRNI questions addressing memory loss, attention difficulties and slowing in reasoning.

Results
One thousand and nineteen PLWH (82% male) with a median age of 70 (IQR = 67–74) years were included. Most participants were on ART (99%). The average number of non-HIV drugs was 5.1 ± 3.6, representing a polypharmacy prevalence of 50%. Two hundred participants (20%) were on ≥1 ACH medication, with an average ACH score of 1.7 ± 1.3. SRNI, adjusted for age, sex, CD4, nadir CD4, viral load, efavirenz use and polypharmacy, was associated with depression (OR = 4.60; 95% CI = 2.62–8.09) and a trend was observed with being on ≥1 ACH medication (OR = 1.69; 95% CI = 0.97–2.95). In a subgroup analysis of participants without depression (n = 911), SRNI was associated with the use of ≥1 ACH medication (OR = 2.51; 95% CI = 1.31–4.80).

Conclusions
ACH medication use is common in elderly PLWH and contributes to SRNI. The effect of ACH medications on neurocognitive impairment warrants further evaluation using neurocognitive tests.