bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Platelet Rich Plasma on the Treatment Outcome of Minigraft/NB-UVB Therapy in Stable Vitiligo: Clinical Evaluation and Effect on Tissue levels of bFGF
Authors: Salem Samar Abdallah Mohamed , Soltan Marwa Yassin , El Khazragy Nashwa , Fezea Tabarek Abdulkhaleq 
Published: October 2021

Abstract

Background
Vitiligo is an acquired pigmentary disorder resulting from loss of melanocytes which causes depigmentation of the skin. Clinically, it is characterized by the progressive loss of melanocytes causing the appearance of well-circumscribed milky white cutaneous macules and patches

Aim of the Work
to evaluate the efficacy of PRP as an additive treatment to the minigraft/NB-UVB treatments for stable localized vitiligo and the effect of this treatment on the expression of bFGF in the lesional treated vitiliginous skin compared before and after the course of treatment.

Patients and Methods
The study represents a prospective interventional comparative study. It was conducted on 17 patients diagnosed as stable vitiligo. All patients were selected from the dermatology outpatient vitiligo clinic of Ain-Shams University hospital from April 2018 to June 2019. All subjects who participated in this study gave written informed consents. The study was approved by the research ethical committee of Ain-Shams University (Approval Number: FWA 000017585) and fulfilled all the ethical aspects required in human research.

Results
We found that the addition of PRP to minigraft resulted in earlier repigmentation as assessed by VESTA score; however, at the follow up end (one month following the end of treatment), both modalities resulted in a similar response as regards the repigmentation percent and improvement in VESTA score. The addition of the PRP to the minigraft didn’t result in a superior improvement than minigraft alone.

Conclusion
Both minigraft and PRP-assisted minigraft followed by NB-UVB sessions are effective method to induce repigmentation in stable vitiligo.
A Comparative study between topical 15% potassium hydroxide and 20% Salicylic acid in treatment of multiple palmoplantar warts
Authors: Elmoalef Wafa Sleman , Elsayed Mahira Hamdy , Elhusseiny Rania Mahmoud 
Published: October 2021

Abstract
Warts are one of the most common benign neoplasms. Warts are induced by over 100 types of human papillomavirus (HPVs) and can affect any race. Various treatments were considered to treat warts, of which topical salicylic acid and KOH are the most commonly used choices.

Aim of the study
To compare between the efficacy, safety and recurrence rate of topical 15% potassium hydroxide (KOH) and 20% Salicylic acid in the treatment of multiple palm plantar warts.

Patients and methods
study included 40 patients complaining of multiple palmar and/or planter warts 2 lesions at least. Each patient was treated by: Salicylic acid 20% used on one lesion and topical 15% KOH preparation used on another lesion. Assessment of patients’ response was done through clinical and dermoscopic examination.

Results
Salicylic acid results revealed that 5% of the treated lesions showed Clinical improvement without dermoscopic clearance, 40% showed Clinical clearance with dermoscopic remnants while 55% showed Clinical and dermoscopic clearance. KOH treated warts showed 5% of the treated lesions had clinical improvement without dermoscopic clearance, 25% showed clinical clearance with dermoscopic remnants while 70% showed clinical and dermoscopic clearance.

Conclusion
KOH therapy as well as patient satisfaction showed higher significant treatment response compared to salicylic acid therapy with less encountered side effects.
Assessment of Human Nuclear Factor Erythroid 2 Related Factor 2 (NRF2) in Androgenetic Alopecia in Egyptian Men
Authors: Diab Heba Mahmoud , Soltan Marwa Yassin , El-khazragy Nashwa , Abdullah Alaa Mohamed 
Published: October 2021

Abstract

Background
Androgenetic alopecia (AGA) is the most common type of hair loss in men. It is commonly known as a male pattern baldness. It is characterized by a stepwise miniaturization of the hair follicle, resulting from alteration in the hair cycle dynamics, leading to vellus transformation of terminal hair follicle. In AGA, the duration of anagen phase gradually decreases and that of telogen phase increases, the maximum length of the new anagen hair becomes shorter than that of its predecessor, leading to miniaturization and eventually a bald appearance.

Aim of the work
To assess the expression of NRF2 in the scalp of men with androgenetic alopecia.

Patients and Methods
This case control study included 28 male patients whose age ranged from 18 to 45 years old. They were diagnosed as having AGA according to Norwood-Hamilton scale. Further, 28 age and sex matched healthy male controls were recruited. All patients and controls were recruited from the dermatology outpatient clinic of Ain-Shams University Hospitals, during the period of September 2018 to April 2019.

Results
A group of Twenty-eight male patients with AGA were recruited to the study. The of patients ranged from 18 to 45 years (mean = 33.46 years ± 9.9 SD). Twenty-eight age matched male healthy volunteers without AGA were e recruited. The majority of AGA patients had positive family history of AGA in their first degree relatives. None of our patients had a medical history of systemic diseases like diabetes mellitus or hypertension.

Conclusion
The current study showed that alteration of Nrf2 levels may play an important role in the pathogenesis of AGA.
Role of Stem Cells in Treatment of Sensorineural Hearing Loss
Authors: El-Halaby Hesham , El-Kahky Ayman , Taha Hesham , Abu-Zahra Fatma , Nada Ihab , Mahmoud Ahmed Saeed 
Published: October 2021

Abstract

Background
More than 5% of the world population lives with a hearing impairment. The main factors responsible for hearing degeneration are ototoxic drugs, aging, continued exposure to excessive noise and infections. The pool of adult stem cells in the inner ear drops dramatically after birth, and therefore an endogenous cellular source for regeneration is absent.

Objectives
The purpose of this study is to evaluate the role of mesenchymal stem cells in the treatment of severe to profound sensorineural hearing loss as regarding permanent regeneration of the auditory hair cells.

Materials and Methods
It is a prospective study which was performed in the period of May 2019 till December 2019 and encountered 40 adult male guinea pigs, aged 6 to 8 weeks (body weight 250-500 gram). 30 guinea pigs had been subjected to right side intratympanic injection of Garamycin sulphate to induce sensorineural hearing loss then the 30 animals were subdivided after that into 2 groups; Group A (15 animals) were treated by mesenchymal stem cells implantation in right inner ear cochlea and group B (15 animals) left untreated and the remaining 10 guinea pigs; Group C left normally as a control group.

Results
As respect to histopathological examination, 100% of animals in group B (n = 15) expressed severe degenerative changes in the peripheral organs. The outer hair cells showed severe destruction with individual loss of the inner hair cells. Also the supporting cells of Corti’s organ presented severe necrosis which was more relevant in the basal turns. We used the bone marrow differentiated MSCs to evaluate their potency in regeneration of the damaged and lost sensorineural elements in gentamicin injured cochlea. In group A (n = 15) 9 out of 15 (60%) expressed profound regeneration and 4 out of 15 (26.66%) expressed early regenerative changes, while 2 animals (13.33%) expressed less degenerative changes which impacted by gentamicin.

Conclusion
Stem cell transplantation is a promising approach for hearing loss therapy. The choice of stem cell type for transplantation plays a crucial role in the outcome. MSCs are multipotent cells that can be isolated from adult bone marrow and can be induced to differentiate into a variety of tissues in vitro and in vivo.
The Effect of Injection of Saline Adrenaline (1/100000) 15ml versus 5ml on the Skin Edema and Thickness in Rhinoplasty Intraoperative
Authors: Rabie Amr Nabil , Begermy Marwa Mohamed El , Mohammed Mohammed Abdelaleem , Mohamed Marwa Saeed Yassin 
Published: October 2021

Abstract

Background
Nasal skin edema is a common result of soft and bony tissue trauma during rhinoplastic procedures. In a cosmetic surgery like rhinoplasty, skin edema can fade the cosmetic results and can lead to dissatisfaction for both the surgeon and the patient. Local saline /adrenaline injection is claimed to reduce the nasal skin edema intraoperative.

Aim of the work
To assess effect of injection of saline adrenaline (1/100000) 15ml versus 5ml on the skin oedema and thickness during rhinoplasty through thesis study.

Subjects and Methods
In this study 30 cases of rhinoplasty will be operated, 15 cases will be injected by saline adrenaline (1/100000) of 5ml and the others 15 cases will be injected by saline adrenaline (1/100000) of 15 ml, then measuring the skin oedema after 10 minutes of saline adrenaline (1/100000) injection, after 30 minutes and after 60 minutes of the injection at three sites; the dorsum, supratip and the tip of the nose by Seal Gouge Caliper (surgical caliber).

Results
the intraoperative skin edema was significantly decreased with local injection of large amount (15ml) of saline /adrenaline 1/100000 than the usual injected amount (5ml) saline /adrenaline 1/100000 specially at the tip and the supratip of the nose and specially at 30 min and 60 min after injection, but statistically significance difference only at 60min at the dorsum.

Conclusion
that the skin oedema much less with injection of 15ml of saline adrenaline (1/100000) in comparison to injection of 5ml of saline adrenaline (1/100000).
Detection of TNF-α as a Cofactor in the Pathogenesis of Nasal Polypi
Authors: Abdelraaof Mohammed , Kamal Tarek Mostafa , Maarouf Ahmed Mahmoud , Ali Zeinab RezkAbd-elnazer 
Published: October 2021

Abstract

Background
Nasal Polyposis (NP) is a complex multi-factorial disease; associated with several environmental, genetic and inflammatory factors. TNF-alpha is one of the major pro-inflammatory cytokines involved in NP pathogenesis. Some of the polymorphisms of this gene affect its expression.

Aim of the Work
To evaluate the polymorphism of TNF-alpha G/A308 gene and its association with nasal polyposis in Egypt.

Patients and Methods
In this case-control study, 25 patients with NP and 25 healthy individuals referred to Ain Shams University hospital were evaluated. After DNA extraction, RFLP-PCR was used to determine polymorphism. Chi-square test was used to compare the frequency distribution of genotype and alleles of TNFalpha gene with NP. The frequency of genotype G/G, A/A and G/A in the NP group was 8, 40 and 52%, and in the control group was 76, 1 and 5%, respectively.

Results
There was a statistically significant difference between genotype G/G in two groups (P = 0.0001). In addition, the frequency of allele A in patients and controls was 10 and 1%, respectively; and this difference was statistically significant (p = 0.0001). The findings of this study demonstrated that polymorphism in TNF-alpha gene might be a risk factor for NP in Egypt and the minor frequency of TNF-alpha G308A allele in the current study is slightly more than other major populations. However, more investigations with high number of population are necessary in future.

Conclusion
According to scientific evidence on TNF-α gene promoter G/A 308 polymorphism in Egypt, it seems that the pattern of genotypic distribution in all areas is the same. However, we found the greater amount of allele A in this study compared with the control group, and the occurrence of G/A genotype related to NP but for more valid results, a larger sample size is necessary. However on our results this polymorphism might be considered as a risk factor of susceptibility of NP in Egyptian people.
Efficiency of Cruroplasty as a Treatment of Gastro-Esophageal Reflux Disease in Morbid Obese Patients with Hiatus Hernia during SleeveGastrectomy
Authors: Sabry Alaa Abbas , Shafik Youhanna Shohdy , Sabry Ahmed Mohamed , Wanees Andrew Nasr Faris 
Published: October 2021

Abstract

Background
The effect of laparoscopic sleeve gastrectomy (LSG) on gastroesophageal reflux disease (GERD) is controversial. Although concomitant hiatal hernia repair (HHR) at the time of LSG is common and advocated by many, there are few data on the outcomes of GERD symptoms in these patients. The aim of this study was to evaluate the effect of concomitant HHR on GERD symptoms in morbidly obese patients undergoing LSG.

Aim of the Work
To analyse the impact of hiatal hernia repair (HHR) on gastro-oesophageal reflux disease (GERD) in morbidly obese patients with hiatus hernia undergoing laparoscopic sleeve gastrectomy (LSG).

Patients and Methods
This is a retrospective cohart study. We collected the data of Patients who underwent lap sleeve gastrectomy with cruroplsty in the same operation in the period between July 2018 and July 2019.

Results
Before surgery, symptomatic GERD was present in 14 patients (70%), and HH was diagnosed In 20 patients (100%), HH was diagnosed pre-operatively. The mean follow-up was 6 months. GERD remission occurred in 18 patients (90%). In the remaining 2 patients, antireflux medications were diminished, with complete control of symptoms. HH recurrences developed in 1 patient (10%). "De novo" GERD symptoms developed in 22.9% of the patients undergoing SG alone compared with 0% of patients undergoing SG plus HHR.

Conclusion
SG with HHR is feasible and safe, providing good management of GERD in obese patients with reflux symptoms. Small hiatal defects could be underdiagnosed at preoperative endoscopy and/or upper gastrointestinal contrast study. Thus, a careful examination of the crura is always recommended intraoperatively.
New techniques in the repair of anal sphincter between success and failure
Authors: Darwish Ahmed A , Khalil Ahmed A , Hamed Mohammed A , AbdAlrahem ElnagehA 
Published: October 2021

Abstract

Background
Fecal incontinence is a frequent and debilitating condition that may result from a multitude of different causes. It is defined as the uncontrolled passage of faeces or gas over at least 1 month’s duration, in an individual of at least 4 years of age, who had previously achieved control.

Aim of Work
to evaluate the outcome of overlap anal sphincter repair as regard the anal continence and postoperative complications.

Patients and Methods
this is a prospective clinical trial was conducted on thirty (30) patients presented to Ain-Shams University hospitals with anal sphincter injury that were operated upon by a modified overlap repair done by the same surgical team. Endoanal ultrasonography was done and Wexner continence score was estimated for all cases preoperatively and postoperatively. All patients sharing in the study were fully informed about the procedure they had with a written informed consent.

Results
In this study the mean preoperative Wexner score was 12.9 and the mean postoperative Wexner was 4.8; this reduction was found to be significant (p value=0.001). Also endoanal ultrasound showed that tear size significantly reduced among the studied cases(p value=0.001).

Conclusion
from this study that overlapping sphincter repair is an effective method in the treatment of faecal incontinence in patients with repairable sphincter defects. However, long term follow up is required to confirm its efficacy.
Modified Sinotomy with Marsuplization versus Excision with Lay Open in Treatment of Pilonidal Sinus Disease
Authors: Abdeer Ashraf Farouk , Elhefny Amr Mohamed , Gerges Wadie Boshra , Sawires John Sobhy Mamlouk 
Published: October 2021

Abstract
Pilonidal sinus disease (PSD) is a common infection of the skin in the gluteal cleft, with a prevalence of 0.7% in the general population. Pilonidal sinus can occur in many different areas of the body but most are found in the sacrococcygeal area, in the natal cleft, approximately 5 cm from the anus. This is a prospective comparative randomized study conducted at Department of General Surgery, Imbaba General Hospital to compare the modified sinotomy with marsupialization versus excision with lay open in treatment of pilonidal sinus disease. Pre-study power analysis revealed that a sample size of 30 patients in each group would be sufficient with 80% power and a P value of 0.05. The perfect approach for the management of PNS should be simple, cause minimal pain, have best chance for success and least recurrence rate with low risk for complications, avoid general anesthesia, require minimal wound care, and ensure minimal inconvenience for the patient with rapid return to normal activity. Number of Patients participated in this study were n = 60 77% of the participants were males aged from 17-52 and 26.3 works as drivers. Operative time in modified sinotomy group ranged from 20-40 minutes and in lay open group ranged from 20-35 min (P-value: 0.07).
Presence of hair in the back in the modified sinotomy group in 83.3% while in the lay open group 76.6% (P-value: 0.004).

In conclusion,
we believe that execution of a minimally invasive surgical technique for PSD can be among the most important methods for treating not only primary PSD but also complicated and recurrent PSD cases.
Effectiveness of White test versus conventional saline test in minimizing biliary leak in partial liver resection in living donor liver transplant
Authors: Mahmoud Amr Ahmed Abd-Elaal , Saber Hatem Sayed , Ibrahim Mahmoud Mohamed Elsayed 
Published: October 2021

Abstract

Background
Intra-operative bile leakage testing is very important in partial liver resection in living donor liver transplant as it allows detection of bile leaking points on the cut surface and decreases postoperative bile leak which is one of the most dreadful complication following liver transplant surgery. In this study we tried to assess the Effectiveness of White test versus conventional saline test in minimizing biliary leak in partial liver resection in living donor liver transplant.

Objective
In this study, we assess whether the White test is better than the conventional saline test for the intraoperative detection of biliary leakage in patients who will undergo partial liver resection as living donor liver transplant.

Methodology
In this study, we assess whether the White test is better than the conventional saline test for the intraoperative detection of bile leakage in patients who underwent partial liver resection as a living donor liver transplant. This study included 60 patients who received partial liver resection as a living donor liver transplant. The conventional saline test (injecting an isotonic sodium chloride solution through the cystic duct) was carried out in 30 patients and the White test (injecting a fat emulsion solution through the cystic duct) was carried out in 30 patients

Results
Incidence of postoperative bile leakage was compared between the conventional method and the White test. Bile leakage occurred in 8 patients (26.7%) in the conventional method group and in 2 patients (6.7%) in the White test group. In addition, the White test detected intraoperative a significantly higher number of bile leakage sites compared with the conventional method. The White test is better than the conventional test for the intraoperative detection of bile leakage.

Conclusion
Based on our study, we recommend that surgeons investigating bile leakage sites during liver resections should use the White test instead of the conventional saline test.
Short-Term Results of Single-Anastomosis Gastric Bypass After Failed Sleeve Gastrectomy
Authors: Sabry Alaa Abbas , Abd-Elsamee Karim Sabry , Mohamed Mohamed Ibrahim , Abd-Elsalam Mohammed Mohamed Ahmed 
Published: October 2021

Abstract

Background
It is already known that Laparoscopic sleeve gastrectomy (LSG) has gained popularity as a stand-alone procedure with good short-term results for weight loss. However, in the long-term, weight regain is considered as a complication. Demand for secondary surgery is rising, partly for this reason, but through that study we try to discover the efficacy of conversion of failed sleeve gastrectomy to one anastomosis gastric bypass (OAGB) regarding weight loss and metabolic outcomes.

Objective
To asses the efficacy and safety of one anastomosis gastric bypass (OAGB) as a conversion surgery post Sleeve Gastrectomy failure as regard weight loss and metabolic outcomes.

Patients and Methods
This study is a retrospective cohort study which included 20 patients underwent one anastomosis gastric bypass at Ain-Shams University El-Demerdash Hospital, Cairo, Egypt and specialized bariatric center, Cairo, Egypt From February 2019 to July 2019 with 6 months of postoperative follow up till January 2019.

Results
In this study, we reviewed and analyzed the outcomes from the revision of the SG due to either inadequate weight loss or weight regain to one anastomosis gastric bypass (OAGB) with %EBWL of 6.65% at 1 month, 13.61 % at 3 months and 20.86% at 6 months.

Conclusion
OAGB appears to be an effective and safe therapeutic technique as a revisional surgery for failed primary SG with good short-term results for treating morbid obesity and its associated comorbidities with a significantly low rate of complications. However the EBWL was less than what is reported after primary OAGB weight. Multicenter studies with larger series of patients and longer term follow up after SG revisions to OAGB are warranted.
Evaluation of Catheter Directed Thrombolytic Therapy versus Systemic Anticoagulant Therapy of Acute Ilio-Femoral Deep Vein Thrombosis
Authors: Akhnoukh Samy Gamil , Wahba Ramez Monuir , Mahmoud Nabil Gamal Abd Elnaser 
Published: October 2021

Abstract

Background
Deep venous thrombosis (DVT) is a major cause of morbidity and mortality all-over the world. Complications include pulmonary embolism (PE), post-thrombotic syndrome (PTS), phlegmasia alba dolens, phlegmasia cerulea dolens and venous gangrene. The PTS is the most common cause of long-term morbidity and disability among the previous complications.

Aim of the Work
The aim of this work is evaluation of the regional catheter-directed thrombolytic therapy versus standard systemic anticoagulant therapy in cases of acute ilio-femoral deep vein thrombosis as regard to efficacy, safety as well as complications.

Patients and Methods
This study was conducted on 30 patients presented to the vascular surgery unit of Ahmed Maher Teaching Hospital between February, 2019 and August, 2019 with acute iliofemoral deep venous thrombosis (less than two weeks duration). Of the 30 patients, 18 were females and 12 were males. The age of the patients ranged between 22 and 55 years.

Results
The outcome results of early Follow up of the thrombolytic therapy was complete recanalization in 30.7% of the cases, partial re-canalization in 53.8% of the cases and poor recanalization in the remaining cases15.3%.While the follow up results of anticoagulant therapy was complete re-canalization in 6.7% of the cases, partial re-canalization in 60% of cases and poor recanalization in the remaining cases 33.3%

Conclusion
Catheter directed thrombolytic therapy using streptokinase, as a lytic agent in the treatment of acute ilio-femoral DVT is a safe and efficient technique.