bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients
Authors: Liu Caidong , Wang Ziyu , Wu Wei , Xiang Changgang , Wu Lingxiang , Li Jie , Hou Weiye , Sun Huiling , Wang Youli , Nie Zhenling , Gao Yingdong , Zhang Ruisheng , Tang Haixia , Wang Qianghu , Li Kening , Xia Xinyi , Li Pengping , Wang Shukui 
Published: April 2021

Abstract
Aims: To classify COVID-19 patients into low-risk and high-risk at admission by laboratory indicators.Design, Setting, and Patients: This is a case series of patients from a China healthcare system in Wuhan. In this retrospective cohort, 3563 patients confirmed COVID-19 pneumonia, including 548 patients in the training dataset, and 3015 patients in the testing dataset.Interventions: NoneMeasurements and Main Results: We first identified the significant laboratory indicators related to the severity of COVID-19 in the training dataset. Neutrophils percentage, lymphocytes percentage, creatinine, and blood urea nitrogen with AUC greater than 0.7 were included in the model. These indicators were further used to build a support vector machine model to classify patients into low-risk and high-risk at admission. Results showed that this model could stratify the patients in the testing dataset effectively (AUC=0.89). Moreover, laboratory indicators detected in the first week after admission were able to estimate the probability of death (AUC=0.95). Besides, we could diagnose COVID-19 and differentiated it from other kinds of viral pneumonia based on laboratory indicators (accuracy=0.97).Conclusions: Our risk-stratification model based on laboratory indicators could help to diagnose, monitor, and predict severity at an early stage of COVID-19.
Dam failure peak outflow prediction through GEP-SVM meta models and uncertainty analysis
Authors: Nobarinia Mohammad , Kalateh Farhoud , Nourani Vahid , Amini Alireza Babaeian 
Published: April 2021

AbstractAccurate prediction of a breached dam's peak outflow is a significant factor for flood risk analysis. In this study, the capability of Support Vector Machine and Kernel Extreme Learning Machine as kernel-based approaches and Gene Expression Programming method was assessed in breached dam peak outflow prediction. Two types of modeling were considered. First, only dam reservoir height and volume at the failure time were used as the input combinations (state 1). Then, soil characteristics were added to input combinations to investigate particularly the impact of soil characteristics (state 2). Results showed that the use of only soil characteristics did not lead to a desired accuracy; however, adding soil characteristics to input combinations (state 2) improved the models' accuracy up to 40%. The outcome of the applied models was also compared with existing empirical equations and it was found the applied models yielded better results. Sensitivity analysis results showed that dam height had the most important role in the peak outflow prediction, while the strength parameters did not have significant impacts. Furthermore, for assessing the best-applied model dependability, uncertainty analysis was used and the results indicated that the SVM model had an allowable degree of uncertainty in peak outflow modelling.
Biodegradation of alicyclic amines by a newly isolated hypersaline tolerant strain Paenarthrobacter sp. TYUT067
Authors: Feng Kaiqing , Zhang Jiandong , Gao Lili , Tian Qi 
Published: April 2021

Abstract
Alicyclic amines are widely used in several types of industries, and considerable attention has been devoted to possible environmental pollution by alicyclic amines in hypersaline industrial wastewater. In this study, a new hypersaline tolerant bacterial TYUT067 capable of growing in liquid basal salt medium with cyclohexylamine (CHAM) as the sole carbon source and energy source, was isolated from soil, and discovered with highly efficient CHAM degrading ability. The strain TYUT067 was identified as Paenarthrobacter sp. based on 16S rDNA gene sequence, and its degradation characteristic was examined. The results revealed that the isolated TYUT067 could grow well under pH range of 6.5–10.0, temperature from 20 °C to 30 °C. For degradation of 60 mM of cyclohexylamine, 100% degradation could be finished within 120 h. The TYUT067 could degrade 10 mM CHAM under hypersaline conditions (3–5% NaCl, w/v), revealed the hypersaline tolerance of TYUT067. Different type of amines was also tested with TYUT067, the degradations of &gt;90% were achieved toward several alicyclic amines. The current results suggested that TYUT067 was a potential species could be efficiently used for the degradation of alicyclic amines and might be applicable to a hypersaline wastewater treatment system for the removal of alicyclic amines.
Current status of textile wastewater management practices and effluent characteristics in Tanzania
Authors: Bidu J. M. , Van der Bruggen B. , Rwiza M. J. , Njau K. N. 
Published: April 2021

Abstract
Textile wastewater from wet processing units is a major environmental problem. Most chemicals, including dyes, are only partly consumed, resulting in highly colored wastewater containing a variety of chemicals released into the environment. This paper gives information on the current management of textile wastewater in Tanzania. A semiquantitative analysis was done to identify the main types of chemicals used in wet processing units, wastewater characteristics and existing wastewater treatment methods in the textile industry. The performance evaluation of the existing wastewater treatment plants is also discussed. The advantages of integrating constructed wetlands with the existing treatment facilities for textile wastewater are explained. It has been observed that pretreatment and dying/printing of the fabrics are the main two processes that produce wastewater in many textile companies. Main pollutants are chemicals used from pretreatment and materials removed from de-sizing, bleaching and scouring processes. Dyes, printing pigments and dye auxiliaries are the main pollutants from the dyeing/printing process. Most of the textile companies in Tanzania are equipped with effluent treatment plants. Wastewater treatment plants have basically similar units, which are coagulation-flocculation, sedimentation through clarifiers and aerobic reactor. However, their effluents do not meet discharge limits stipulated by the Tanzania Bureau of Standards (TBS).
The Role of Chest High Resolution CT and RT-PCR in Diagnosis of Different Stages of Coronavirus (COVID-19) Pneumonia
Authors: Kassem Mohamed N.E. , Masallat Doaa T. 
Published: April 2021

Purpose:
The purpose of this study is to investigate how RT-PCR (real time–polymerase-chain-reaction) and chest High-Resolution Computed Tomography
(HRCT) can detect COVID-19 (Coronavirus Disease 2019) disease in the early, progressive and severe stages, as well as patient’s outcome.

Method:
We perform a prospective study with chest HRCT on 206 patients with positive RT-PCR test. The patients were divided into three groups; early
stage (100 patients), progressive stage (70 patients) and severe stage (36 patients).

Results:
The early stage involved typical category (COVID-19 Reporting and Data System, CO-RADS 5, 34 cases - 34%), indeterminate category (CORADS
3, six cases - 6%), atypical category (CO-RADS 4, ten cases - 10%) and normal chest HRCT imaging (CO-RADS 1, 50 cases - 50%). The
progressive stage involved a typical category (CO-RADS 5, 70 cases, 100%), The severe stage involved a typical category (CO-RADS 5, 36 cases,
100%).

Conclusion:
RT-PCR is the gold standard and specific tool for confirming COVID-19 infection. Combination of RT-PCR and chest HRCT is used for the early
diagnosis of COVID-19 pneumonia. Chest HRCT is positive in 50% of patients in the early stage of COVID-19. Chest HRCT is not only detecting
pulmonary parenchymal changes but also determining patient’s outcome in the progressive and severe stages of COVID-19 (CO-RADS 5).
Patients with progressive stage will not need ventilator and patients with severe stage should receive ventilator.
Insight Into Bioactive Hydrogels for Wound Healing and Drug
Delivery Systems
Authors: Li Jing , Chen Qinhua , Wang Jin , Pan Xiaoyan , Zhang Jie 
Published: April 2021

:
Hydrogels are hydrophilic but water-soluble polymer systems with a three-dimensional
network structure. They can absorb large amounts of water and maintain their
shape and remain soft. The high-moisturizing properties, good biocompatibility, and controlled
biodegradability of hydrogels have allowed them to be widely used in wound
dressing, tissue engineering, controlled drug delivery systems, and other fields. This article
reviews the most widely used antibacterial gel dressings for wound healing in recent
years and focuses on the application of an environmentally responsive intelligent hydrogel
delivery system. Finally, the development prospects and challenges of hydrogel
wound dressings are forecasted.
The Impact of Physical Exercise on the Hippocampus in Physiological Condition and Ageing-Related Decline: Current Evidence from Animal and Human Studies
Authors: Lauretta Giovanni , Ravalli Silvia , Maugeri Grazia , D’Agata Velia , Rosa Michelino Di , Musumeci Giuseppe 
Published: April 2021

Abstract:Physical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results in a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various parts of the body, determining biological and psychological benefits. Additionally, in the elderly, PE might represent a remarkable tool reducing cognitive impairments related to the normal aging processes and it has also been found to have an impact on neurodegenerative diseases such as Alzheimer’s disease. The present review aims to provide an overview of PE effects on the hippocampus, since it is one of the brain regions most susceptible to aging and, therefore, involved in diseases characterized by cognitive impairment.
Wound Healing Properties of Exosomes — A Review and Modelling
of Combinatorial Analysis Strategies
Authors: Liew Fong Fong , Chew Boon Cheng , Ooi Der Jiun 
Published: April 2021

:
Wound healing is an elaborated process, well-regulated via cell migration and proliferation. Although the physiological basics of wound healing have been thoroughly investigated and reported, much remain to be studied. Particularly, various studies have demonstrated the immunomodulatory roles of exosomes derived from plant cells, mammalian cells and mesenchymal stem cells (MSCs) in the healing and repair system. The paracrine and therapeutic effects of exosomes are mainly associated with the broad exosomal cargo content comprising of growth factors, cytokines, enzymes, nucleic acids, proteins and lipid signaling molecules. Nevertheless, functional or mechanism pathway of exosomes with reference to overall exosomal cargo remains undetermined. To date, combinatorial analysis strategies employing Database for Annotation, Visualization, and Integrated Discovery (DAVID), STRING tools, Gene Ontology (GO), Kyoto Encyclopedia of Genes, Genomes (KEGG) pathway enrichment analysis, as well as Ingenuity Pathway Analysis (IPA) have been applied in elucidating network interaction and functional pathway of exosomes. In this review paper, application of combinatorial analysis strategies is demonstrated to better understand on the therapeutic potentials of exosomes in wound healing process. In conclusion, functional modulation of exosomal cargo for specify biological treatment is achievable, modelling of combinatorial analysis strategies will hopefully bridge the research gap and provides a paradigm shift to regenerative processes.
Management of Procedural Pain in Children
Authors: Páramo-Cano Tatjana , Ortiz Mario I. , Gómez-Busto Federico J. , Espinoza-Ramírez Ana L. 
Published: April 2021

:In recent years, there has been increased interest in the study of pain in children and its treatment. It is known that when facing diagnostic and therapeutic procedures similar to those performed on adults, children either do not receive specific pain treatment or receive it on a significantly lower scale. However, recent research suggests a change in attitude and an improvement in the current treatment of children's pain. Although current knowledge demonstrates the falsity of many preconceived ideas about pain and its management, our results suggest that attitudinal change towards childhood pain remains slow and that real improvement in the training and practical application of the pediatrician who has to treat childhood pain is urgently needed. In this context, this manuscript has prepared standards and guidelines to improve pain management practices in a large number of national and international professional settings.
A Study of Pregnancy-Related Anxiety with Spiritual Health Among Cesarean and Vaginal Delivery
Authors: Haydari Naval , Dejbakhat Majid , Akbarzadeh Marzieh 
Published: April 2021

Background:One of the most important causes of anxiety during pregnancy is postpartum anxiety and the effects that this anxiety can have on the health of mother and infant and the role that studies have considered for spiritual health in promoting mental health.Objective:the aim of this study is to investigate the correlation between anxiety and spiritual health of mothers with cesarean section and vaginal delivery.Methods:This study was performed on 171 women referred to Amir al-momenin (PB) in Gerash Hospital (Fars, Iran) from August 2017 to October 2018. Convenience sampling was used. Data were collected through Demographic Information Questionnaire, Spielberger Anxiety Inventory, and Pulotzin and Ellison Spiritual Health Questionnaire. Data were analyzed by descriptive statistical methods including mean, standard deviation and frequency percentage and analytical methods, such as independent t-test and Pearson correlation.Results:There was no significant difference between the mean of total score of anxiety (P = 0.560) and spiritual health (P = 0.313) in mothers with cesarean section and vaginal delivery). There was no significant correlation between maternal spiritual health, maternal anxiety, cesarean delivery (r = -0.111, p = 0.269) and vaginal delivery (r = 0.152, p = 0.209).Conclusion:In this study, anxiety and spiritual health were not different among cesarean section and vaginal delivery women and unlike other studies, no correlation was found between spiritual health and anxiety. However, further studies in this field and attention to other strategies to control labor anxiety among women seem necessary.
Dietary Nutrients and Prevention of Alzheimer’s Disease
Authors: Chauhan Pallavi Singh , Yadav Dhananjay , Arukha Ananta Prasad 
Published: April 2021

:
Alzheimer’s disease is an irrevocable, progressive brain disorder that gradually destroys
memory and cognitive skills. One of the extensively studied methods of preventing Alzheimer’s
disease (AD) progression is by providing a nutritional diet. Several reports have shown that intake
of nutritional elements as huperzine A, ursolic acid, vitamins etc., can directly influence pathogenesis
of AD. Surprisingly, the occurrence of metabolic disorders due to an unhealthy diet has been
known to be a major environmental cause of AD. It has been noted that AD severity can be controlled
by supplementing dietary supplements containing huge amounts of health-promoting ingredients.
These elements promote cell health, regeneration, and the anti-aging process that specifically
interrupt the pathogenic pathways in AD development. Fortunately, incorporating changes in the
nutritional content is inexpensive, easy, acceptable, safe, effective, and in most cases, free from major
adverse events. Many nutritional phytoconstituents such as flavonoids, alkaloids, and terpenoids
are still being evaluated in the hope of identifying a successful therapy for AD. This review
discusses the therapeutical potential of several key nutrients that have been researched for
treating AD treatment and the method of their neuroprotective intervention.
The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles
Authors: Teffera Yohannes , Liu Jingzhou , Krolikowski Paul , Zhao Zhiyang 
Published: April 2021

Introduction:
A group of substituted benzothiazoles from a research project was found
to have low microsomal clearance. However, these compounds had very high clearance in vivo.

Methods:
In the present study, the clearance mechanism of two of the structural analogs, was investigated
in vitro and in vivo.

Results:
In vitro studies showed the formation of corresponding non-P450 dependent oxidative
metabolites in S9, cytosol, and hepatocytes. The in vitro formation of these metabolites was observed
in mice, rats, non-human primates, and humans. The dog did not form the corresponding
metabolites in any of the matrices. Inhibition studies with S9 fraction and incubation with human
recombinant aldehyde oxidase (AO) showed that the formation of the corresponding metabolites
was AO dependent. To investigate the role of this pathway in vivo, mice were dosed with compound
A and bile and plasma were analyzed. Most of the metabolites in bile contained the AO-dependent
oxidized benzothiazole moiety, indicating that metabolism involving AO was probably the
main pathway for clearance. The same metabolites were also observed circulating in plasma. Mass
spectrometric analysis of the metabolite showed that the oxidation was on the benzothiazole moiety,
but the exact position could not be identified. Isolation of the metabolite of compound A and
analysis by NMR confirmed the structure of the metabolite as C2 carbon oxidation of the thiazole
ring resulting in carboxamide moiety. Further comparison of both metabolites with corresponding
authentic standards confirmed the structures.

Conclusion:
To our knowledge, such an observation of in vitro and in vivo oxidation of substituted
benzothiazole by AO has not been reported before. The results helped the medicinal chemists design
compounds that avoid AO-mediated metabolism and with better ADME property.
Hubungan Tingkat Partisipasi dengan Tingkat Kesejahteraan Masyarakat dalam Pengembangan Wisata Pesisir
Authors: Anandhyta Annisya Rakha , Kinseng Rilus A. 
Published: April 2021

Abstrak Berdasarkan UU No. 10 Tahun 2009 tentang Kepariwisataan, Pariwisata adalah macam-macam kegiatan wisata dan didukung berbagai fasilitas serta layanan yang disediakan oleh masyarakat, pengusaha, pemerintah, dan pemerintah daerah. Salah satu kawasan pariwisata yang dimiliki Indonesia adalah wilayah pesisir. Pengembangan kawasan wisata dapat dilakukan melalui partisipasi aktif masyarakat dalam rangka menciptakan lapangan pekerjaan baru dan menyejahterakan masyarakat. Penelitian ini bertujuan untuk melihat hubungan antara tingkat partisipasi dengan tingkat kesejahteraan anggota Pokdarwis Baron Indah dalam pengembangan kawasan wisata Pantai Baron. Metode yang digunakan adalah pendekatan kuantitatif yang didukung oleh data kualitatif. Data kuantitatif diperoleh melalui kuesioner dan data kualitatif diperoleh melalui wawancara mendalam menggunakan panduan wawancara serta observasi lapang. Teknik dalam penentuan responden penelitian menggunakan cluster accidental sampling. Hasil penelitian menunjukkan bahwa sebagian besar anggota Pokdarwis Baron Indah berada pada tingkat partisipasi sedang. Penelitian ini juga menunjukkan adanya hubungan positif yang signifikan antara tingkat partisipasi dengan tingkat kesejahteraan. AbstractBased on Law No. 10 of 2009 concerning tourism, tourism is defined as a variety of tourism activities and supported by various facilities and services provided by the community, entrepreneurs, government, and local governments. One of the tourism areas that Indonesia has is a coastal region. The development of tourism areas can be done through active community participation in order to create new jobs and improve the welfare of the community. This study aims to investigate the relationship between the level of participation with the level of welfare of members of Pokdarwis Baron Indah in the development of the Baron Beach tourism area. The method used is a quantitative approach and supported by qualitative data. Quantitative data obtained through questionnaires and qualitative data obtained through in-depth interviews using interview guides and field observations. Respondents were selected by “accidental sampling cluster” method. The results showed that the level of participation of most of the Pokdarwis Baron Indah members fall within the medium category. This study also shows that the level of participation and the level of welfare of Pokdarwis members are positively and significantly correlated.
Humoral Response to the Pfizer BNT162b2 Vaccine in Patients Undergoing Maintenance Hemodialysis
Authors: Grupper Ayelet , Sharon Nechama , Finn Talya , Cohen Regev , Israel Meital , Agbaria Amir , Rechavi Yoav , Schwartz Idit F. , Schwartz Doron , Lellouch Yonatan , Shashar Moshe 
Published: April 2021

Background and objectives
Coronavirus disease 2019 (COVID-19) is associated with higher morbidity and mortality in patients on maintenance hemodialysis. Patients on dialysis tend to have a reduced immune response to infection or vaccination. We aimed to assess, for the first time to the best of our knowledge, the humoral response following vaccination with the BNT162b2 vaccine in patients on maintenance hemodialysis and the factors associated with it.

Design, setting, participants, & measurements
The study included 56 patients on maintenance hemodialysis (dialysis group) and a control group composed of 95 health care workers. All participants had received two doses of the BNT162b2 (Pfizer-BioNTech) vaccine. The serology testing was done using Quant II IgG anti-Spike severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assay by Abbott a median of 30 days after receipt of the second dose of the vaccine.

Results
All subjects in the control group developed an antibody response compared with 96% (54 of 56) positive responders in the dialysis group. The IgG levels in the dialysis group (median, 2900; interquartile range, 1128–5651) were significantly lower than in the control group (median, 7401; interquartile range, 3687–15,471). A Mann–Whitney U test indicated that this difference was statistically significant (U=1238; P<0.001). There was a significant inverse correlation of age and IgG levels in both groups. The odds of being in the lower quartile were significantly higher for older individuals (odds ratio, 1.11 per year of age; 95% confidence interval, 1.08 to 1.20; P=0.004) and for the dialysis group compared with the control group (odds ratio, 2.7; 95% confidence interval, 1.13 to 7.51; P=0.05). Within the dialysis group, older age and lower lymphocyte count were associated with antibody response in the lower quartile (odds ratio, 1.22 per 1-year older; 95% confidence interval, 1.13 to 1.68; P=0.03 and odds ratio, 0.83 per 10-e3/µl-higher lymphocyte count; 95% confidence interval, 0.58 to 0.97; P=0.05).

Conclusions
Although most patients on maintenance hemodialysis developed a substantial humoral response following the BNT162b2 vaccine, it was significantly lower than controls. Age was an important factor in the humoral response, regardless of chronic medical conditions.