bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transepithelial Corneal Cross-linking With Supplemental Oxygen in Keratoconus: 1-Year Clinical Results
Authors: Matthys Alex , Cassagne Myriam , Galiacy Stéphane D. , El Hout Safa , Fournié Pierre , Malecaze François 
Published: January 2021

PURPOSE:
To evaluate the efficacy and safety of transepithelial corneal cross-linking (CXL) with supplemental oxygen.

METHODS:
This was a prospective, non-comparative, pilot cohort study conducted at the National Reference Center for Keratoconus (Toulouse, France) on patients with progressive keratoconus. Transepithelial, pulsed, accelerated CXL was performed in an oxygen-rich atmosphere. Oxygen goggles were applied to the eyes to maintain a high level of oxygen during treatment. The main efficacy outcome was the mean change from baseline in maximum keratometry (Kmax) and the secondary outcomes were the mean changes in flat keratometry (K1), steep keratometry (K2), mean keratometry (Km), corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA), and demarcation line depth. The safety outcomes were the incidence of adverse events, the mean change in pachymetry, and endothelial cell count.

RESULTS:

Thirty-four eyes of 34 patients were included. At 12 months postoperatively, the Kmax decreased by 1.56 ± 1.71 diopters (D) (
P
< .0001) and CDVA improved by 0.093 ± 0.193 logMAR (
P
< .02). The K2 and Km decreased by 0.51 ± 1.03 D (
P
< .02) and 0.40 ± 0.78 D (
P
< .01), respectively. There was no change in K1 and UDVA. The most frequent adverse event was corneal haze (64.78%). There were neither cases of infectious keratitis or loss of more than two lines in CDVA nor changes in pachymetry or endothelial cell count.

CONCLUSIONS:
Transepithelial CXL performed in an oxygen-rich atmosphere results in improved Kmax and CDVA with good safety. These promising findings suggest that this procedure could be safe and capable of halting the progression of keratoconus.

[
J Refract Surg
. 2021;37(1):42–48.]
Health Literacy: An Interactive Outcome Among Secondary Students in Beijing
Authors: Guo Shuaijun , Yu Xiaoming , Davis Elise , Armstrong Rebecca , Naccarella Lucio 
Published: January 2021

Background:
Health literacy enables a person to make good decisions regarding health care, disease prevention, and health promotion to maintain and improve health. Although health literacy research in China has gained increasing attention in recent years, most existing studies focus on adults rather than adolescents. In addition, little theory-driven empirical research has been conducted to fully understand the relationship among health literacy, its influencing factors, and health outcomes scored on a skills-based health literacy instrument.

Objective:
This study applied Manganello's framework to investigate how health literacy was related to its antecedents and health status in secondary students in Beijing, China.

Methods:
A cross-sectional study was conducted with 650 students in Years 7 to 9 (age 11–17 years) from four secondary schools. Students completed a self-administered questionnaire based on Manganello's health literacy framework, which measured key upstream determinants, including health literacy and self-report health status. Health literacy was measured on an 8-item skills-based instrument that assesses a person's ability to find, understand, appraise, and communicate health information in everyday life (scores range from 0–37). Descriptive statistics and path analysis were conducted to investigate the mediating role of health literacy in predicting health status.

Key Results:

Overall, the average scores of students' health literacy was 26.37 (±5.89). Manganello's framework was supported by the data collected (

χ
2

/df = 2.049,
p
= .001, comparative fix index = 0.966, root mean square error of approximation = 0.041). Personal self-efficacy (
r
= 0.11, p = .007), social support (
r
= 0.18, p < .001), and school environment (
r
= 0.27,
p
< .001) predicted health literacy, which in turn predicted students' health status (
r
= 0.12,
p
= .005).

Conclusions:

Adolescent health literacy is not only a person's capability to protect health, but also an interactive outcome with the broader environment. Promoting health literacy could be a useful strategy to improve health status for adolescents; however, a holistic approach is needed to increase students' self-efficacy, promote social support, and create positive school environments to achieve optimal health literacy and health outcomes.

[
HLRP: Health Literacy Research and Practice.
2021;5(1):e1–e14.]

Plain Language Summary:
We investigated how health literacy was related to its influencing factors and health status among secondary students in Years 7 to 9 in Beijing, China. Students with low self-efficacy, low social support, and low perceptions of positive school environment were more likely to have low health literacy, which in turn predicted poor health status.
Gadget-Based Interactive Multimedia on Socio-Scientific Issues to Improve Elementary Students’ Science Literacy
Authors: Suryanti Suryanti , Widodo Wahono , Yermiandhoko Yoyok 
Published: January 2021

<span lang="EN-US">Students’ science literacy in Indonesia is considered very low and needs improvement. Knowledge, such as science, can be learned naturally and effectively in social context (Social Scientific Issues/SSI). The current elementary students are regarded as generation Z students who are interested in technology and skill-based education, namely, interactive multimedia. This study aimed to develop SSI Gadget-based interactive multimedia in order to improve elementary students’ science literacy skills. This is a Research and Development study with 4-D model; define, design, develop, disseminate. The subjects of this research were 23 students. The data were collected using validation sheet, observation sheet and science literacy test. The data then </span><span lang="IN">being </span><span lang="EN-US">analyzed </span><span lang="IN">by </span><span lang="EN-US">using descriptive statistic of presentation and N-gain. The result indicated that interactive multimedia based on SSI-Gadget are compatible as an alternative learning medium to improve elementary students’ science literacy since they met the criteria of being, a) very valid with a score of 3.55; b) good practicality </span><span lang="IN">in it </span><span lang="EN-US">so that the students dominantly did their activities through the developed media; c) effective, as there were positive responses about the learning activities and the students improved their science literacy skills from level 3 to level 4, with an N-gain of 0.4.</span>
Case Report: Ascending Myelo-Encephalitis after a Penetrating Injury to the Foot: An Atypical Case of Neuromelioidosis
Authors: Varkey Maramattom Boby , Rathish Balram 
Published: January 2021

ABSTRACTOrganisms penetrate the central nervous system (CNS) via three routes. The commonest is the hematogenous route, and other routes include contiguous or penetrating injury or rarely via retrograde axoplasmic route. Although the axoplasmic highway is often used by viruses, only a few bacteria are known to penetrate the CNS via this route. We present a 57-year-old man who developed a penetrating injury while working in a field. Over the next 4 months, he developed pain at the site of the poorly healing wound, which ascended up the right leg and presented as a conus-cauda syndrome. Magnetic resonance imaging (MRI) showed an enhancing intradural intramedullary enhancing lesion in the conus on the right side with cord edema from D11 to L1 level. Extensive evaluation was negative, and he continued to progress to holocord myelitis and developed bilateral corticospinal tract lesions (“tractopathy”) in the brain stem and internal capsule. He died after developing a right-sided cerebritis with mass effect. Tissue biopsy from the brain at the time of decompressive craniectomy grew Burkholderia pseudomallei and confirmed a diagnosis of neuromelioidosis (NM). We reviewed the literature for NM, its variable presentations, and the concept of an “infectious tractopathy” and imaging findings which could generate suspicion of this entity.
Echocardiographic Screening Detects a Significant Burden of Rheumatic Heart Disease in Australian Torres Strait Islander Children and Missed Opportunities for its Prevention
Authors: Hempenstall Allison , Howell Erin , Kang Katherine , Chau Ken W. T. , Browne Amylou , Kris Ella , Wapau Hylda , Pilot Pelista , Smith Simon , Reeves Benjamin , Hanson Josh 
Published: January 2021

ABSTRACTRheumatic heart disease (RHD) is almost entirely preventable, but its incidence in indigenous Australians remains one of the highest in the world. A community-based echocardiogram screening program of 862 Torres Strait Islander children identified 25 (2.9%) new cases of RHD. Among these 25 children, 5/7 (71%) prior acute rheumatic fever presentations had not been recognized. There was a history of microbiologically confirmed group A Streptococcus infection in 17/25 (68%) children with RHD compared with 9/25 (36%) controls (odds ratio [OR] [95% CI]: 3.78 [1.17–12.19], P = 0.03). This was more likely to be a skin swab (16/25 [64%] cases versus 6/25 [24%] controls) than a throat swab (1/25 [4%] cases versus 3/25 [12%] controls) (OR [95% CI]: 5.33 [1.51–18.90] [P = 0.01]), supporting a role for skin infection in RHD pathogenesis. Household crowding and unemployment were common in the cohort, emphasizing the need for prioritizing strategies that address the social determinants of health.
Case Report: Isolated Central Nervous System Melioidosis from a Non-Endemic Area
Authors: Mishra Biswamohan , Vishnu Venugopalan Y. , Bhatia Rohit , Garg Ajay , Doddamani Ramesh Sharanappa , Singh Parul , Chand Sharma Mehar , Singh Mamta Bhushan , Rajan Roopa , Gupta Anu , Srivastava Madakasira Vasantha Padma 
Published: January 2021

ABSTRACTCentral nervous system (CNS) melioidosis is a rare neurological infectious disease which carries a high mortality. We describe a previously healthy middle-aged female, who presented to us with left-sided hemiparesis and was on antitubercular therapy from a previous presumed diagnosis of CNS tuberculoma. Non-characteristic imaging picture, multiple negative body fluid cultures, and positive Cerebrospinal fluid galactomannan led to a further delay in diagnosis. Gram stain of the tissue obtained from brain biopsy revealed Gram-negative rods in “safety pin” appearance. By picking up the colonies that appeared on blood agar and MacConkey agar, the identification of the clinical isolates was performed using VITEK® matrix (BioMérieux, Marcy-L’Etoile, France)-assisted laser desorption ionization time-of-flight mass spectrometry (VITEK MALDI TOF MS database version 3.2) which revealed Burkholderia pseudomallei. After the institution of appropriate treatment, she survived but with significant morbidity. A high index of suspicion should be kept for such previously healthy individuals belonging to non-endemic areas, where presentation is suspicious of an infective etiology, but not improving despite appropriate therapy. This may help in early recognition and institution of recommended treatment so that mortality can be avoided.
Synthesis, structural elucidation and electrochemical behavior of some oxime-phenylalanine mixed ligand complexes
Authors: T. Öztoprak U. , P. Özkorucuklu S. , Y. Baştemur G. , E. Tunçmen M. , Karipcin F. 
Published: January 2021

Four new mixed ligand complexes Me(II)/phenylalanine (phe)/HL [HL =4-(4-bromophenyl- aminoisonitrosoacetyl)biphenyl and Me = Co, Ni, Cu, Zn] were synthesized. These complexes are formulated as: [CoL(phe)(H2O)2], [NiL(phe)(H2O)2], [CuL(phe)(H2O)2] and [ZnL(phe)(H2O)2]. All the compounds were characterized by elemental analyses, FT-IR, magnetic susceptibility measurements, TG/DTA and cyclic voltammetry (CV) experiments. IR spectral data confirmed the coordination of the oxime ligand to the metal ions through the oxime and carbonyl oxygen. The geometrical structures of the complexes have been found to be octahedral. The measured molar conductance values of the complexes in DMF are in agreement with the non-electrolytic nature ofthe complexes. The elemental analyses confirm a 1:1:1 [metal:HL:L(phenylalanine)] molar ratio. Thermal behavior of the compound was investigated by thermal gravimetric analysis (TG) and differential thermal analysis (DTA) techniques. All the complexes were transformed into metal oxides after thermal degradation. The electrochemical properties of both ligand and their complexes were analyzed by cyclic voltammetry (CV) using glassy carbon electrode in DMF solution containing 0.1 M TBAP as supporting electrolyte.

KEY WORDS: Oxime, electrochemical characterization, mixed ligand complexes, amino acid, phenylalanine

Bull. Chem. Soc. Ethiop. 2020, 34(3), 543-556.
DOI: https://dx.doi.org/10.4314/bcse.v34i3.10
Study of the histidine complex of uranium(IV): synthesis, spectrophotometric, magnetic and electrochemical properties
Authors: Nazir M. , Khattak R. , S. Khan M. , I. Naqvi I. 
Published: January 2021

We synthesized the novel histidine complex of uranium(IV). A 1:3 mole ratio was found between metal and ligand by the mole ratio method, while –NH2 and –COO– groups of histidine behave as coordinating sites. The IR spectra confirmed the lone pair donating or coordinating sites. The elemental analysis confirmed the stoichiometry. The bathochromic shift with an increase in the optical density in the UV-Visible range indicated that the compound and its central metal ion hold uniform electronic charge distribution. The electrochemical results indicated a quasi-reversible (neither completely reversible nor completely irreversible) oxidation of the complex to its uranium(V) product at the platinum working electrode. The quasi-reversible process shows a comparatively slow electron transfer (ET) rate with the heterogeneous electron transfer rate constant ‘ks’ (3.4 × 10–4 cm s-1) at 50 mV s-1 and 305 ± 0.5 K. The kinetics such as diffusion and charge transfer lead the reaction with an ECE (electrochemical–chemical–electrochemical) mechanism. The thermodynamic parameters of activation such as ΔH*; 4.257 kJ mol–1, ΔS*; -2.519 × 10–3 J mol–1 K–1 and ΔG* 4.26 kJ mol–1 helped to propose an associative mechanism of the electron transfer at the platinum working electrode.

KEY WORDS: Uranium, Histidine, Spectroscopy, Electrochemistry, Kinetics

Bull. Chem. Soc. Ethiop. 2020, 34(3), 557-569.
DOI: https://dx.doi.org/10.4314/bcse.v34i3.11
Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats
Authors: A. Osunniran W. , A. Obaleye J. , C. Tella A. , O. Ayipo Y. , T. Bale A. , O. Rajee A. 
Published: January 2021

Transition metal complexes of Cu(II), Co(II) and Ni(II) with eflornithine hydrochloride hydrate (EFN), an antitrypanosomiasis drug, as ligand have been synthesized and characterized by melting point, elemental analysis, Fourier transform infrared (FTIR), electronic spectra, magnetic susceptibility and electrospray ionization mass spectrometry (ESI-MS). The FTIR spectral data suggested the coordination modes of the ligand to be bidentate, coordinated to the metal ions through its carboxylate oxygen atom and an amino nitrogen atom. From the microanalytical data, the stoichiometry of the metal complexes is 1:2 (metal to ligand). The electronic absorption and magnetic susceptibility studies generally suggested octahedral geometry for the metal complexes. Toxicological evaluation of the ligand (EFN) and complexes were carried out using albino rats. Twenty-five albino rats that were used for the experiment were randomly divided into five groups and animals in group 1 served as a control. All the animals were sacrificed twenty-four hours after completion of their doses. The results revealed a high level of toxicity of EFN than the synthesized metal complexes.

KEY WORDS: Eflornithine hydrochloride hydrate, Carboxylate moiety, Antitrypanosomiasis drug, Toxicological evaluation, Albino rats

Bull. Chem. Soc. Ethiop. 2020, 34(3), 489-500.
DOI: https://dx.doi.org/10.4314/bcse.v34i3.6
PRÁTICA ESPACIAL COTIDIANA NO PROCESSO DE SIGNIFICAÇÃO DA APRENDIZAGEM EM GEOGRAFIA
Authors: Christan Patrícia , Camilo de Souza Vanilton 
Published: January 2021

A prática espacial cotidiana é uma dimensão do processo de produção do espaço geográfico. Os sujeitos, ao produzirem as estratégias de sobrevivência, vão produzindo o espaço e formando conhecimentos por meio das relações sociais que estabelecem. Por isso, defende-se que as práticas espaciais cotidianas dos alunos sejam mobilizadas e problematizadas no ensino de Geografia. Nesta perspectiva, apresenta-se uma reflexão sobre a prática espacial cotidiana, considerando-a como elemento de significação da aprendizagem em Geografia. As considerações apresentadas derivam da pesquisa desenvolvida durante o doutorado, em que se constatou, nos relatos dos professores, a preocupação com as demandas dos alunos, muitas delas relacionadas às experiências vivenciadas em suas práticas espaciais, o que reforça sua potencialidade no ensino de Geografia, pois propiciam a compreensão das dinâmicas dos espaços em que estão inseridos.
PALAVRAS-CHAVE
Prática espacial cotidiana, Ensino e aprendizagem em Geografia, Prática pedagógica.

LA PRÁCTICA ESPACIAL COTIDIANA EN EL PROCESO DE SIGNIFICACIÓN DEL APRENDIZAJE EN GEOGRAFÍA
RESUMEN
La práctica espacial cotidiana es una dimensión del proceso de producción del espacio geográfico, los sujetos al producir las estrategias de supervivencia van produciendo el espacio y formando conocimientos por medio de las relaciones sociales que establecen. Por eso, se defiende que las prácticas espaciales cotidianas de los alumnos sean movilizadas y problematizadas en la enseñanza de Geografía. En esta perspectiva se presenta una reflexión sobre la práctica espacial cotidiana considerándola como elemento de significación del aprendizaje en Geografía. Las consideraciones presentadas derivan de la investigación desarrollada durante el doctorado, en la que se constató en los relatos de los profesores la preocupación con las demandas de los alumnos, muchas de ellas están relacionadas con las experiências vivenciadas en sus prácticas espaciales. Esto puesto, refuerza su potencialidad en la enseñanza de Geografía, pues propician la comprensión de las dinámicas de los espacios en los que están insertados.
PALABRAS CLAVE
Práctica espacial cotidiana, Enseñanza y aprendizaje en Geografía, Práctica pedagógica.
TRAÇADOS DO COTIDIANO DE PEQUENOS SERTANEJOS NA AULA DE GEOGRAFIA EM UMA ESCOLA CAMPONESA NA BAHIA
Authors: Matos de Oliveira Guilherme 
Published: January 2021

Este artigo tem como objetivo elucidar a realização de uma prática pedagógica do ensino de Geografia em uma escola camponesa do interior da Bahia no ano de 2018, sendo que os pequenos estudantes camponeses que compunham a turma do 6o ano dessa instituição produziram, na aula da disciplina, desenhos do espaço sertanejo local partindo de suas casas à escola em que estudavam, no intento de refletirem os conteúdos que estavam sendo trabalhados em classe: orientação e localização na produção do espaço agrário. Sendo assim, nos propomos a tecer análises sobre o ensino de Geografia na luta por uma educação do campo ao descrevermos a prática em questão. Entendemos que mesmo sendo uma ação simples desenvolvida em sala de aula, na qual os estudantes camponeses traçaram o cotidiano sertanejo que vivem por meio de ilustrações, a mesma tornou-se significativa a eles na compreensão das transformações que se estabelecem no campo de forma contextualizada, ao estudarem o espaço em que se encontram inseridos tanto naquele momento quanto durante o ano letivo. Diante dessa realidade, é preciso que lutemos em defesa de uma Geografia escolar do campo, pautada pela emancipação humana dos sujeitos sociais camponeses nos seus territórios de vida e de trabalho.
PALAVRAS-CHAVE
Camponeses, Educação do Campo, Ensino de Geografia.

TRACES OF EVERYDAY OF SMALLS BACKCOUNTRY IN THE GEOGRAPHY CLASS AT A PEASANT SCHOOL IN BAHIA
ABSTRACT
This article aims to elucidate the realization of a pedagogical practice of teaching Geography in a peasant school in the interior of Bahia in the year 2018, being that the small peasant students who made up the 6th grade class at this institution produced, in the discipline class, drawings of the local backcountry space starting from their homes to the school where they studied, in an attempt to reflect the contents that were being worked on in class: orientation and location in the production of the agrarian space. Thus, we propose to analyzes about the teaching of Geography in the struggle for field education by describing the practice in question. We understand that same being a simple action developed in the classroom, in which the peasant students traced the daily life in the backcountry that they live through illustrations, the same became significant to them in understanding the transformations that are established in the field in a contextualized, when studying the space in which they are inserted, so much at that moment how much during the school year. In view of this reality, it is necessary that we fight in defense of a school geography in the field, ruled for the human emancipation of social subjects peasant in their territories of life and of work.
KEYWORDS
Peasants, Field education, Teaching Geography.
O ENSINO DE GEOGRAFIA:
Authors: Reclus Élisée 
Published: January 2021

Texto escrito por Élisée Reclus em 1901 e publicado originalmente na revista do Institut de Géographie da Nouvelle Université Libre de Bruxelas (no 5, vol. 1, 1901). A tradução foi realizada a partir da reedição da publicação, pela revista Ciel et Terre, março de 1902.

RECLUS, Élisée. L'enseignement de la géographie: globes, disques globulaires et reliefs. Revue Ciel et Terre. Bruxelas, vol. 23, 1902, p. 29-38.
Tradução de Sergio Aparecido Nabarro. Doutor em Geografia pela Universidade de São Paulo (USP) e Professor Visitante no Institut de Géographie da Université Paris 1 (Panthéon-Sorbonne), França.