bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of the One Anastomosis Gastric Bypass with Various Biliopancreatic Limb Lengths: a Retrospective Single-Center Cohort Study
Authors: Slagter Nienke , de Heide Loek J. M. , Jutte Ewoud H. , Kaijser Mirjam A. , Damen Stefan L. , van Beek André P. , Emous Marloes 
Published: July 2021

Abstract
Introduction
One anastomosis gastric bypass (OAGB) is an effective and safe treatment for morbidly obese patients. Longer biliopancreatic (BP) limb length is suggested to result in better weight loss outcomes, but to date, no data are available for the OAGB to substantiate this. We hypothesized that applying a longer BP-limb length in the higher BMI classes would result in more weight reduction so that the attained BMI would be comparable to patients with a lower BMI, thereby compensating for differences in baseline BMI.

Method
A retrospective cohort study in patients who underwent a primary OAGB at a teaching hospital in the Netherlands between January 2015 and December 2016. BP-limb length was tailored based on preoperative BMI. Patients were divided into three different groups depending on the length of the BP-limb: 150, 180, and 200 cm. Weight loss outcomes after 1 and 3 years and resolution of comorbidities were compared between these groups.

Results
Of the 632 included patients, a BP-limb length of 150 cm was used in 172 (27.2%), 180 cm in 388 (61.4%), and 200 cm in 72 (11.4%) patients. Despite more BMI loss, %EWL was lower and attained BMI remained higher in the groups with longer BP-limb lengths. After adjustment for the confounder preoperative BMI, longer BP-limb lengths were not associated with higher BMI loss. There was no difference in remission rates of comorbidities.

Conclusion
Attained BMI remained higher in spite of tailoring BP-limb length according to baseline BMI with no differences in remission rates of comorbidities.

Graphical Abstract
“One stop” clinic for upper gastrointestinal cancer—an alternative to “straight to test” referrals?
Authors: Yiasemidou Marina , Lathan Ross , Lambertz Manfred , Oommen Chitakattil , Chetter Ian 
Published: July 2021

Abstract
Background
Patients suspected to have upper gastrointestinal (UGI) cancer can be referred directly for investigation; however, at times this may result to inappropriate referrals. This study explores the model of a “one-stop” clinic as an alternative to the direct referral system. The current study aims to assess the feasibility and outcomes of a one-stop UGI clinic and evaluate sensitivity and specificity of “on-the-day” diagnoses.

Methods
A retrospective analysis of case notes of patients seen in one-stop clinic, between January 2017 and January 2019, was conducted. All General Practitioner (GP) referrals were screened by a specialist nurse.

Results
After completion of the post-GP referral screening process, 252 patients (median age 68 years, IQR 58.8–77.3 years; M:F ratio 118:134) were allocated to the one-stop clinic. OGD was not required, contra-indicated or declined in 27 cases (10.7%). The records of three patients could not be found. One patient did not attend. Overall, 221 patients underwent testing and received “on-the-day” diagnoses. Sensitivity was 94% (range 87–100%), and specificity was 92% (88–96%). Ninety-six percent of patients received a diagnosis on the day.

Conclusions
The one-stop clinic was feasible and had good specificity and sensitivity. The finding of 10.7% of cases not being suitable for OGD indicates that a patient/specialist consultation is necessary to prevent misuse of endoscopy appointments. The authors recommend widespread adoption of one-stop clinics in UGI surgery.
Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease
Authors: Betancor Marina , Moreno-Martínez Laura , López-Pérez Óscar , Otero Alicia , Hernaiz Adelaida , Barrio Tomás , Badiola Juan José , Osta Rosario , Bolea Rosa , Martín-Burriel Inmaculada 
Published: July 2021

AbstractThe non-toxic C-terminal fragment of the tetanus toxin (TTC) has been described as a neuroprotective molecule since it binds to Trk receptors and activates Trk-dependent signaling, activating neuronal survival pathways and inhibiting apoptosis. Previous in vivo studies have demonstrated the ability of this molecule to increase mice survival, inhibit apoptosis and regulate autophagy in murine models of neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrPC) into an abnormal and misfolded isoform known as PrPSc. These diseases share different pathological features with other neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson’s disease or Alzheimer’s disease. Hitherto, there are no effective therapies to treat prion diseases. Here, we present a pilot study to test the therapeutic potential of TTC to treat prion diseases. C57BL6 wild-type mice and the transgenic mice Tg338, which overexpress PrPC, were intracerebrally inoculated with scrapie prions and then subjected to a treatment consisting of repeated intramuscular injections of TTC. Our results indicate that TTC displays neuroprotective effects in the murine models of prion disease reducing apoptosis, regulating autophagy and therefore increasing neuronal survival, although TTC did not increase survival time in these models.
Synchronous gastric cancer and primary lymphoma of right adrenal gland: a case report
Authors: Fukuda Shuichi , Wakasa Tomoko , Hanamoto Hitoshi , Koyama Taichi , Ohta Yoshio , Inoue Masatoshi , Terashita Daisuke , Gakuhara Atsushi , Tomihara Hideo , Ohta Katsuya , Kitani Kotaro , Hashimoto Kazuhiko , Ishikawa Hajime , Hida Jin-ichi , Kimura Yutaka 
Published: July 2021

AbstractThis report presents an extremely rare case of synchronous gastric cancer and primary adrenal diffuse large B-cell lymphoma (DLBCL). An 82-year-old man underwent computed tomography, which revealed a heterogeneous appearing and hypodense adrenal mass and a gastric mass with no enlarged lymph nodes in the neck, mediastinum, abdomen, and inguinal region. Upper gastrointestinal endoscopy revealed a protruding gastric tumor. The specimens obtained from endoscopic biopsy were histologically confirmed to be adenocarcinoma. The hormonal findings eliminated functional adrenal tumor. The patient underwent distal gastrectomy with regional lymph node resection for gastric cancer and incisional biopsy of the adrenal mass. Based on the pathological findings, diagnoses of mixed mucinous and tubular adenocarcinomas of the stomach and adrenal DLBCL were confirmed. Postoperation, the patient received rituximab combined with low-dose doxorubicin, cyclophosphamide, vincristine, and prednisone (R-miniCHOP). Six courses of R-miniCHOP were planned, but were completed in only one course at the patient’s request. The patient died 2 months after surgery.
Sutureless aortic valve with supracoronary ascending aortic replacement as an alternative strategy for composite graft replacement in elderly patients
Authors: Olsthoorn J. R , Lam K. Y. , Akca F. , Timmermans N. M. A. J. , Tan M. E. S. H. 
Published: July 2021

AbstractAortic valve disease is frequently associated with ascending aorta dilatation and can be treated either by separate replacement of the aortic valve and ascending aorta or by a composite valve graft. The type of surgery is depending on the exact location of the aortic dilatation and the concomitant valvular procedures required. The evidence for elective aortic surgery in elderly high-risk patients remains challenging and therefore alternative strategies could be warranted. We propose an alternative strategy for the treatment of ascending aortic aneurysm and aortic valve pathology with the use of a sutureless, collapsible, stent-mounted aortic valve prosthesis.
Study on separation factor models for well anti-collision analysis
Authors: Madeira Rafael A. , Sui Dan 
Published: July 2021

AbstractAnti-collision analysis has been becoming even more important in the past few years with the increasing amount of wells drilled in highly congested fields. The separation factor (SF) is a critical safety parameter to avoid wellbore collisions, where the pedal curve method (PCM) is the commonly used way for the SF calculation. However, such method may be conservative in many situations and possibly triggers an unnecessary early stop drilling due to its conservation. In this study, our work aims to evaluate and compare the different types of the SF models. In addition, an alternative and supplement method of the PCM, called as elliptic cylinder of uncertainty (ECoU) method, is proposed. The radius of the ECoU considers the distance of the intersecting points of the center-to-center line and the cylinder surfaces of both reference and offset wells. By introducing the cylinder surfaces into the SF calculation, it could extend the collision avoidance along the whole well path to reduce multiple-points collision possibility. The findings in the study help us for better understanding of the SF analysis and also show that using the ECoU indication has a great potential in fields applications as a viable method to keep the drilling operations’ safety.
Possible Reactivation of SARS-CoV-2 in a Patient with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: a Case Report
Authors: Dalla Via Vera , von Rotz Matthias , Bättig Veronika , Leuzinger Karoline , Hirsch Hans H. , Passweg Jakob , Stüssi Georg , Medinger Michael 
Published: July 2021

AbstractReactivation or reinfection cases of SARS-CoV-2 are known but there is scarce evidence about reactivation in immunocompromised patients. Here, we report the case of a 61-year-old male undergoing a conditioning regimen with fludarabine, cyclophosphamide, and 2-Gy total body irradiation in preparation of a haplo-identical allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML). He received the first dose of a COVID-19 vaccine 6 weeks prior allo-HSCT and was hospitalized a month prior because of a COVID-19 bilateral pneumonia. On discharge, he showed two negative SARS-CoV-2 nasopharyngeal PCR swabs as well as a high SARS-CoV-2 antibody titer. On admission for allo-HSCT, he tested negative for SARS-CoV-2 again. Conditioning with fludarabine, cyclophosphamide, and 2-Gy total body irradiation was started and the patient developed lymphopenia. During his hospital stay, he tested positive for SARS-CoV-2 in a PCR test twice but remained asymptomatic. The conditioning regimen was continued as planned. Later during his stay, the patient showed undetectable SARS-CoV-2 load four times. This case documents possible reactivation of SARS-CoV-2 and raises questions about reactivation risks among recipients of stem cell transplants and other immunocompromised patients.
$$L_2$$-norm sampling discretization and recovery of functions from RKHS with finite trace
Authors: Moeller Moritz , Ullrich Tino 
Published: July 2021

AbstractIn this paper we study $$L_2$$

L
2

-norm sampling discretization and sampling recovery of complex-valued functions in RKHS on $$D \subset \mathbb {R}^d$$

D
⊂

R

d

based on random function samples. We only assume the finite trace of the kernel (Hilbert–Schmidt embedding into $$L_2$$

L
2

) and provide several concrete estimates with precise constants for the corresponding worst-case errors. In general, our analysis does not need any additional assumptions and also includes the case of non-Mercer kernels and also non-separable RKHS. The fail probability is controlled and decays polynomially in n, the number of samples. Under the mild additional assumption of separability we observe improved rates of convergence related to the decay of the singular values. Our main tool is a spectral norm concentration inequality for infinite complex random matrices with independent rows complementing earlier results by Rudelson, Mendelson, Pajor, Oliveira and Rauhut.
The influence of subject heterogeneity and absorptive capacity of acquirer on innovation performance in technology-driven M&As
Authors: Peng Michael Yao-Ping , Li Rui 
Published: July 2021

AbstractThis study uses a sample of technological mergers and acquisitions (M&As) of A-share listed companies in the five major high-tech industries from 2012 to 2016, and conducts factor analysis to measure the heterogeneity of these enterprises in terms of financial slack resources, equity resources, and governance structure. On this basis, multivariate regression analysis is utilized to explore the influence of the acquiring firms' heterogeneity on their innovation performance, and the adjustment action of absorptive capacity between heterogeneity and innovation performance. The research results show that the slack financial resources and highly centralized equity structure of enterprises are not conducive to enterprises improving their innovation performance following a technological M&A, while the impact of governance structure on innovation performance following an M&A is similarly not significant. The empirical evidence provided offer insights and a decision reference for technological M&As of high-tech enterprises.
Determination of the Sun‐Climate Relationship Using Empirical Mathematical Models for Climate Data Sets
Authors: Orssengo Girma J. 
Published: July 2021

AbstractPrevious studies have reported that human influences are required to explain the observed global warming using a linear model (LM) that relates change in solar forcing to change in global mean temperature (GMT) . This model has the shortcoming of assuming a given causes the same irrespective of the value of the initial global warming rate . Analysis of the GMT data showed that this warming rate has been increasing linearly since steady state ( for year ) as given by , where °C/year2 is the secular GMT acceleration and is the number of years of the change. The secular solar forcing due to 18% of the 11 yr solar cycle forcing of 0.19 W/ (0.08% of Total Solar Irradiance) was expressed as . Defining the climate sensitivity as °C/year per W/ removed the shortcoming of the LM and integration of the model for above and then simplifying gave a secular GMT‐solar forcing model given by that explained all of the observed global warming and increase in atmospheric , sea level and ocean heat content. Therefore, for this nonlinear empirical model, invoking human influences to explain climate change was not required. The annual GMT model predicts a pause in global warming until 2040.
A Generalized Interpolation Material Point Method for Shallow Ice Shelves. 2: Anisotropic Nonlocal Damage Mechanics and Rift Propagation
Authors: Huth Alex , Duddu Ravindra , Smith Ben 
Published: July 2021

AbstractIce shelf fracture is responsible for roughly half of Antarctic ice mass loss in the form of calving and can weaken buttressing of upstream ice flow. Large uncertainties associated with the ice sheet response to climate variations are due to a poor understanding of these fracture processes and how to model them. Here, we address these problems by implementing an anisotropic, nonlocal integral formulation of creep damage within a large‐scale shallow‐shelf ice flow model. This model can be used to study the full evolution of fracture from initiation of crevassing to rifting that eventually causes tabular calving. While previous ice shelf fracture models have largely relied on simple expressions to estimate crevasse depths, our model parameterizes fracture as a progressive damage evolution process in three‐dimensions (3‐D). We also implement an efficient numerical framework based on the material point method, which avoids advection errors. Using an idealized marine ice sheet, we test the creep damage model and a crevasse‐depth based damage model, including a modified version of the latter that accounts for damage evolution due to necking and mass balance. We demonstrate that the creep damage model is best suited for capturing weakening and rifting over shorter (monthly/yearly) timescales, and that anisotropic damage reproduces typically observed fracture patterns better than isotropic damage. Because necking and mass balance can significantly influence damage on longer (decadal) timescales, we discuss the potential for a combined approach between models to best represent mechanical weakening and tabular calving within long‐term simulations.
Vitamin D and family history of hypertension in relation to hypertension status among college students
Authors: Cuffee Yendelela L. , Wang Ming , Geyer Nathaniel R. , Saxena Sangeeta , Akuley Suzanne , Jones Lenette , Wilson Robin Taylor 
Published: July 2021

AbstractHypertension and vitamin D concentrations have heritable components, although these factors remain uninvestigated in young adults. The objective of this study was to investigate hypertension risk among young adults with respect to family history of hypertension, adjusting for vitamin D status. Resting blood pressure (BP) was measured in 398 individuals aged 18–35 and classified according to the 2017 American Heart Association criteria. Plasma vitamin D metabolite (25(OH)D3; 24,25(OH)2D3; 1,25(OH)2D3) concentrations were determined using liquid chromatography tandem mass spectrometry (LC-MS/MS). Stepwise logistic regression was used to select covariates. Participants' mean age was 21, 30.3% had hypertension, and nearly all unaware of their hypertensive status (90.7%). Compared with no parental history, the adjusted odds ratio (AOR) for hypertension was elevated among participants with two parents having hypertension (AOR = 4.5, 95% CI: 1.70–11.76), adjusting for sex, body mass index, physical activity, and plasma 25(OH)D3. Results for systolic hypertension (SH) were similar but more extreme (two parents AOR = 7.1, 95% CI: 2.82, 17.66), although dihydroxy metabolites (1,25(OH)2D3 and 24,25(OH)2D3) were significant. There was a strong, independent association with dual parental history and hypertension status, regardless of vitamin D status. Hypertension was prevalent in nearly one-third of the sample and underscores the need for targeted prevention for young adults.
Primary cytomegalovirus infection during pregnancy and congenital infection: a population-based, mother–child, prospective cohort study
Authors: Shimada Kyoko , Toriyabe Kuniaki , Kitamura Asa , Morikawa Fumihiro , Minematsu Toshio , Ikejiri Makoto , Suga Shigeru , Toyoda Hidemi , Amano Keishiro , Kitano Masako , Usui Satoko , Masuda Sawako , Ikeda Tomoaki 
Published: July 2021

Abstract
Objective
This study assessed maternal cytomegalovirus antibodies, and the occurrence of primary and congenital cytomegalovirus infections, and risk factors of congenital infection after a maternal primary infection.

Study design
We included 19,435 pregnant women in Japan, who were tested for serum cytomegalovirus antibodies before 20 gestational weeks. Immunoglobulin (Ig) G avidity was evaluated in women with both IgG and IgM antibodies; tests were repeated at ≥28 gestational weeks among women without IgG and IgM antibodies.

Result
Primary and congenital infections were 162 and 23 cases, respectively. The risk ratios for congenital infection were 8.18 (95% confidence interval: 2.44–27.40) in teenage versus older women, and 2.25 (95% confidence interval: 1.28–3.94) in parity ≥ 2 versus parity ≤ 1. Of 22 live birth congenital infection cases, three had abnormal neurological findings.

Conclusion
We demonstrated teenage and parity ≥ 2 pregnant women as risk factors of post-primary congenital infection.
Quantum discord of thermal two-photon orbital angular momentum state: mimicking teleportation to transmit an image
Authors: Chen Lixiang 
Published: July 2021

AbstractWe formulate a density matrix to fully describe two-photon state within a thermal light source in the photon orbital angular momentum (OAM) Hilbert space. We prove the separability, i.e., zero entanglement of the thermal two-photon state. Still, we reveal the hidden quantum correlations in terms of geometric measures of discord. By mimicking the original protocol of quantum teleportation, we demonstrate that the non-zero quantum discord can be utilized to transmit a high-dimensional OAM state at the single-photon level. It is found that albeit the low fidelity of teleportation due to the inherent component of maximally mixed state, the information of all parameters that characterize the original state can still be extracted from the teleported one. Besides, we demonstrate that the multiple repetitions of the protocol, enable the transmission of a complex-amplitude light field, e.g., an optical image, regardless of being accompanied with a featureless background. We also distinguish our scheme of optical image transmission from that of ghost imaging.
Cell surface carbohydrates of symbiotic dinoflagellates and their role in the establishment of cnidarian–dinoflagellate symbiosis
Authors: Tortorelli Giada , Rautengarten Carsten , Bacic Antony , Segal Gabriela , Ebert Berit , Davy Simon K , van Oppen Madeleine J H , McFadden Geoffrey I 
Published: July 2021

Abstract
Symbiodiniaceae algae are often photosymbionts of reef-building corals. The establishment of their symbiosis resembles a microbial infection where eukaryotic pattern recognition receptors (e.g. lectins) are thought to recognize a specific range of taxon-specific microbial-associated molecular patterns (e.g. glycans). The present study used the sea anemone, Exaiptasia diaphana and three species of Symbiodiniaceae (the homologous Breviolum minutum, the heterologous-compatible Cladocopium goreaui and the heterologous-incompatible Fugacium kawagutii) to compare the surface glycomes of three symbionts and explore the role of glycan–lectin interactions in host–symbiont recognition and establishment of symbiosis. We identified the nucleotide sugars of the algal cells, then examined glycans on the cell wall of the three symbiont species with monosaccharide analysis, lectin array technology and fluorescence microscopy of the algal cell decorated with fluorescently tagged lectins. Armed with this inventory of possible glycan moieties, we then assayed the ability of the three Symbiodiniaceae to colonize aposymbiotic E. diaphana after modifying the surface of one of the two partners. The Symbiodiniaceae cell-surface glycome varies among algal species. Trypsin treatment of the alga changed the rate of B. minutum and C. goreaui uptake, suggesting that a protein-based moiety is an essential part of compatible symbiont recognition. Our data strongly support the importance of D-galactose (in particular β-D-galactose) residues in the establishment of the cnidarian–dinoflagellate symbiosis, and we propose a potential involvement of L-fucose, D-xylose and D-galacturonic acid in the early steps of this mutualism.