bluuebunny/crossref_metadata_2025_split huggingface dataset:
UTILIZAÇÃO DE TREINAMENTO GAMIFICADO PARA CAPACITAÇÃO DE PROFESSORES EM ENSINO A DISTÂNCIA
Authors: Velasco Schleich Melissa , Araujo Pinto Sabrina 
Published: April 2021

Além dos desafios contemporâneos relacionados à motivação dos alunos e à adequação de metodologias e estratégias ao mundo digital, a recente pandemia de COVID-19 e o consequente isolamento social trouxeram à educação novas implicações: a impossibilidade de aulas presenciais destacou a necessidade de se repensarem o ensino a distância e as técnicas de didáticas digitais. Dentro desse contexto, elaborou-se um treinamento gamificado, com o objetivo de prover capacitação rápida e acessível em métodos e linguagens digitais para professores em âmbito nacional. O foco do presente trabalho foi expor, sob o ponto de vista de profissionais da educação, a avaliação da ferramenta criada. Os dados obtidos a partir desta pesquisa demonstraram uma taxa de retenção de concluintes que gira em torno do dobro da média nacional para cursos a distância em geral. Adicionalmente, a análise do feedback dos participantes concluintes indica forte preferência por treinamentos gamificados em detrimento de treinamentos tradicionais on-line, devido, principalmente, aos fatores de entretenimento, interatividade e inovação na forma de aprendizagem.
PROBLEM BASED LEARNING COM TECNOLOGIAS DIGITAIS DA INFORMAÇÃO E COMUNICAÇÃO NA APRENDIZAGEM NO ENSINO DE COMPUTAÇÃO
Authors: Pereira Flavio , Mercado Luis Paulo Leopoldo , Lima Secco Rosemeire 
Published: April 2021

As Tecnologias Digitais da Informação e Comunicação (TDIC) assumem papel relevante como recursos de ensino dos conteúdos curriculares. O docente é motivado a fazer o uso de diversas tecnologias dentro e fora de sala de aula, tais como software e interfaces da internet, para tornar a aula mais interessante, além do desejo em mudar a dinâmica. Docentes têm recorrido ao uso de metodologias ativas, como estudos de caso, aulas-laboratório, trabalhos em grupo, simulações, Aprendizagem Baseada em Problemas ou Problem Based Learning (PBL), nas quais o estudante participa ativamente do processo de aprendizagem e o docente realiza sondagem de conhecimentos prévios do aluno, além de problematização, contextualização e aplicação prática dos conhecimentos. A intenção é tornar as aulas mais próximas da realidade do estudante, tornando-o um ser ativo em sua aprendizagem. Neste artigo, exploramos a importância do uso das TDIC com PBL no ensino superior, por meio de duas sequências didáticas aplicadas em sala de aula, no curso de Sistemas de Informação, da Universidade Federal de Alagoas, e de Análise e Desenvolvimento de Sistemas, do Instituto Federal de Santa Catarina. A primeira, utilizando o software Unity 3D; a segunda, fazendo uso do aplicativo Socrative, com a metodologia PBL e com o uso da ferramenta e-mail. Com o objetivo de verificar a satisfação dos estudantes envolvidos, foi aplicado um questionário sobre a metodologia PBL. Os resultados em diferentes cursos de diferentes instituições comprovaram que a utilização da metodologia proporcionou uma melhor comunicação entre os estudantes. Apesar de necessitar de mais preparação por parte de docentes e tutores, constata-se que a PBL é uma metodologia interessante para ser aplicada no ensino superior, tanto presencial quanto a distância.
Opioid dependence among people with haemophilia in a low-resource tropical setting: prevalence and risk factors in northern Nigeria
Authors: Ahmed Sagir G. , Ibrahim Umma A. , Kagu Modu B. 
Published: April 2021

Abstract

Background
In tropical countries such as Nigeria, where factor VIII (FVIII) is scarce, severe pain due to musculoskeletal bleeding complications, leading to frequent opioid prescription, is not uncommon in poorly managed people with haemophilia (PWH). The relationship between opioid use and dependence is intensively studied in other painful diseases, such as cancer and rheumatoid arthritis, but surprisingly little is known about opioid dependence in haemophilia. We hypothesise that the risk of opioid dependence among PWH in tropical countries like Nigeria is multi-factorial, encompassing demographic (age), clinical (haemophilia severity and chronic arthropathy) and biological (ABO blood groups and haemoglobin (Hb) phenotypes) factors that may directly or indirectly increase incidence of bleeding and/or pain.

Aims
To determine the prevalence of opioid dependence and relative risks (RR) associated with age, haemophilia severity, chronic arthropathy, ABO blood groups and Hb phenotypes, and to elucidate the pathophysiological roles of each risk factor in the development of opioid dependence among haemophilia-A patients in five hospitals in northern Nigeria.

Methodology
A retrospective review of the medical records of 88 PWH seen between 1996 and 2012 was used to collate data on age, sex, haemophilia severity, painful chronic haemophilic arthropathy, ABO blood group, haemoglobin phenotypes, presence or absence of opioid dependence, and the types of opioids on which the patients were dependent. The prevalence of opioid dependence among the cohort was expressed as a percentage. The frequency of each putative risk factor for opioid dependence in patients with and without opioid dependence were compared using Fisher’s exact test; RR associated with each risk factor was determined by regression analysis. P<0.05 was taken as significant.

Results
Of the 88 PWH studied,15 (17%) were shown to be opioid-dependent. Compared with PWH who were not opioid-dependent, this group had higher frequencies of severe haemophilia (86.7% vs. 49.3%: RR= 5.2, p=0.02), survival to adulthood (73.3% vs. 12.3%: RR= 9.5, p=0.0001), chronic arthropathy in one or more joints (86.7% vs. 21.9%: RR= 13.2, p=0.0004), blood group-O (80% vs. 49.3%: RR= 3.3, p=0.04), and HbAA phenotype (86.7% vs. 54.8%: RR= 4.3, p=0.04).

Conclusion
Prevalence of opioid dependence among PWH treated at five hospitals in northern Nigeria was 17% during the study period. Significant risk factors were directly or indirectly associated with increased rates of bleeding and/or pain, which can only be prevented or treated through optimal application of FVIII. There is a need for the Nigerian government to establish standard haemophilia care centres with adequate FVIII for optimal prophylaxis and treatment in order to minimise painful complications, thereby helping to prevent undue opioid use and dependence.
Supervisor Support as a Moderator between Flexible Working Arrangement and Job Performance – Malaysia Evidence
Authors: Et.al Eni Suriana Binti Alias 
Published: April 2021

Over the past years, organizations are forced to redesign their workplace to fulfil global labour market needs and to remain competitive. Due to the ever-changing working environment and competitive markets, organizations opted to choose more flexible work options so they can respond to the volatile environment. This study explores the moderation effect of supervisor support (SS) between flexible working arrangements (FWAs) and employee performance (EP). The population for this study primarily focused on the organizations that adopt the flexible working arrangement such as flexible working time, working from home, and compressed work-week practices in Malaysia. The companies selected are based on the listing of global organizations practices FWAs mentioned in TalentCorp Malaysia Flexible Working Arrangement collaboration with Malaysian Federation Employer report, 2015. The questionnaires were distributed through the Human Resource Department of each organization. The result demonstrated that there is a relationship between FWAs and EP but there was no moderation effect of SS between FWAs and EP relationship. This study supports the idea that the employees seem to benefit from the adoption of FWAs at the workplace. It allows both gender and single or married employees to manage their time better particularly allowing the employees to attend to personal needs. Since FWAs itself is the support given by employers to employees, therefore, the employees were unable to associate supervisor support role as a contributor to help them manage their work and home responsibilities. This study showed that employee motivation to perform are affected by the policies adopted by organizations. Adopting efficient work practices such as FWAs could stimulate employee engagement to improve their work performance. Therefore, organizations that are currently searching for a strategy that can improve productivity and employee performance should consider FWAs as an option. However, the implementation ofFWAs needs to be customized according to the employee's needs. Offering FWAs in the organization will enhance organizational and individual outcomes.
Modeling Student’s Academic Performance During Covid-19 Based on Classification in Support Vector Machine
Authors: Et. al. Nor Ain Maisarah Samsudin, 
Published: April 2021

This study proposed a statistical investigate the pattern of students’ academic performance before and after online learning due to the Movement Control Order (MCO) during pandemic outbreak and a modelling students’ academic performance based on classification in Support Vector Machine (SVM). Data sample were taken from undergraduate students of Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI). Student’s Grade Point Average (GPA) were obtained to developed model of academic performances during Covid-19 outbreak. The prediction model was used to predict the academic performances of university students when online classes was conducted. The algorithm of Support Vector Machine (SVM) was used to develop a model of students’ academic performance in university. For the Support Vector Machine (SVM) algorithm, there are two important parameters which are C (misclassification tolerance parameter) and epsilon need to identify before proceed the further analysis. The parameters was applied to four different types of kernel which is linear kernel, radial basis function kernel, polynomial kernel and sigmoid kernel and the result was found that the best accuracy achieved by SVM are 73.68% by using linear kernel and the worst accuracy obtained from a sigmoid kernel which is 67.99% with parameter of misclassification tolerance C is 128 and epsilon is 0.6.
Development of 3D Concrete Extrusion Nozzle for Producing Free-form Concrete Panels
Authors: Et.al Ji-Yeong, Yun 
Published: April 2021

There has been an increase in demand for free-form building through the development of advanced technologies, and the fourth industrial revolution has become a worldwide trend, thereby changing the construction industry. In particular, in the case of the free-form architecture sector, development of 3D printing technologies has been ongoing for construction automation. According to such trends, this study develops an FCP production equipment using 3D printing technologies. The FCP production equipment in this study is made up of mould equipment and 3D printer. It is different from existing 3D printing technologies so in this study 3D concrete extrusion nozzle must be developed for producing FCP. Basic design suitable to such requirements is proposed. Applicability of the proposed design is checked and the nozzle form is concretized to draft the final drawing. In this study, slit-type opening and closing device for accurate extrusion stoppage of concrete and screw-type nozzle for adjusting pressure and extrusion speed were applied for the nozzle. This is expected to be innovative technology for the FCP production sector.
Síndrome de Guillain Barré e infección por SARS-CoV-2: reporte de dos casos en Perú.
Authors: Segura-Chávez Darwin , Ordinola-Calle Deysi , Tagle-Lostaunau Isabel , Aquino-Peña Francisco , Sifuentes-Monge Juan 
Published: April 2021

La enfermedad por coronavirus 2019 (COVID-19), provocada por el virus SARS-CoV-2, se manifiesta principalmente a nivel respiratorio. Sin embargo, puede afectar otros órganos y sistemas, entre ellos el sistema nervioso, generando diversas manifestaciones neurológicas en las que se incluye el síndrome de Guillain Barré (SGB). Presentamos dos casos de pacientes varones de 35 y 46 años con SGB, uno clasificado como neuropatía axonal motora aguda (AMAN) y el otro como polineuropatia inflamatoria desmielinizante aguda (AIDP), quienes mostraron serología positiva para SARS-CoV-2 y sintomatología respiratoria previa al cuadro de debilidad. En ambos casos, la reacción en cadena de polimerasa en tiempo real (RT-PCR) en secreción faríngea y liquido cefalorraquideo fue negativa. El diagnóstico de infección por SARS-CoV-2 fue confirmado por prueba de anticuerpos totales en suero, mediante inmunoensayo CLIA (Chemiluminescent Immunoassay), positiva para IgG en ambos casos. Las características de los casos presentados sustentan una posible relación posinfecciosa entre el SARS-CoV-2 y el SGB y abren, además, la posibilidad de que, a pesar de que los pacientes sean asintomáticos o presenten síntomas respiratorios leves, podrían desarrollar complicaciones posinfecciosas tales como SGB.
Entrustable Professional Activities in Orthopaedics
Authors: Watson Adam , Leroux Timothy , Ogilvie-Harris Darrell , Nousiainen Markku , Ferguson Peter C. , Murnahan Lucas , Dwyer Tim 
Published: April 2021

Background:
An entrustable professional activity (EPA) is defined as a core task of a specialty that is entrusted to a trainee once sufficient competence has been reached. A group of EPAs reflects the activities that clinicians commonly do on a day-to-day basis. Lists of EPAs have been created for most medical subspecialties, but not orthopaedic surgery. The aim of this study was to create a peer-reviewed list of essential EPAs that a resident must perform independently before completing orthopaedic residency training.

Methods:
A focus group of 7 orthopaedic surgeons from the University of Toronto developed a comprehensive list of 285 EPAs. For each subspecialty group, the opinions of at least 15 academic and nonacademic surgeons, as well as subspecialty-trained and non–subspecialty-trained surgeons, were used. The modified Delphi method was used to rank EPAs on a five-point scale from not important to mandatory for a resident to competent before exiting training. Two Delphi rounds were used, using a threshold of >50% of surgeons considering the EPA as mandatory before being considered for the next round. A final list of EPAs was ratified using the focus group of academic surgeons involved in the study.

Results:
Seventy-five (75) of 107 (70%) surgeons invited responded to the survey. Nearly half (129) of the 285 EPAs were discarded after the first round of Delphi. A further 118 EPAs were discarded after the second Delphi round, leaving 49 final EPAs, across 9 subspecialties in orthopaedic surgery.

Conclusions:
Expert consensus was used to create a list of EPAs considered mandatory for completion of resident training in orthopaedics in our province. The final 49 peer-reviewed EPAs will be a valuable benchmark in curriculum design and assessment in orthopaedic surgery in the competency-based era for other programs.
Multi-center randomized trial of Compound Kushen injection for decreasing radiation- induced thoracic toxicity in lung cancer patients
Authors: Yu Qingxi , Wang Jun , Wang Fan , Yin Haitao , Li Xia , Yuan Shengli , Yang Fujun , Xia Bing , Jia Zhongyao , Liu Sen , Zhang Kaixian , Jiang Xuechao , Liu Fengchun , Wang Luanqiu , Deng Junji , Tong Xu , Liu Shuyan , Lin Hongsheng , Yuan Shuanghu 
Published: April 2021

Abstract
Background: Thoracic radiation therapy plays an important role in the treatment of inoperable lung cancer. However, radiotherapy-induced toxicity poses an important challenge for radiation oncologists. Research has shown that Compound Kushen Injection (CKI) has anti-inflammatory activity and can reduce toxicity when given with chemotherapy. So, we hypothesis CKI can decrease chemoradiotherapy-induced thoracic toxicity in lung cancer patients and conducted this randomized, multi-center study. Methods: A prospective, open, randomized, multi-center，phase IV trial was performed, in which a total of 296 lung cancer patients were enrolled and randomly divided 1:1 into experimental and control groups. The control group received standard chemoradiotherapy including precise thoracic radiotherapy (60 Gy/30 fractions/6 weeks) plus concurrent platinum-based chemotherapy. The experimental group received standard chemoradiotherapy plus CKI via mainline treatments of 250 ml CKI (20 ml diluted in 0.9% normal saline) daily for 20 continuous days. The incidence of adverse events and severity of thoracic toxicity after treatment were observed according to version 4.0 of the Common Terminology Criteria for Adverse Events. Adverse drug reactions (ADRs) and quality of life (QLQ-C30) also were compared between the two groups.Results: Two hundred ninety-one qualifying patients were included in the statistical analysis. Symptomatic radiation-induced thoracic toxicity was lower in the experimental group than in the control group (14.1% vs 25.6%, p=0.017). According to QLQ-C30 questionnaire findings, CKI provided superior outcomes related to pain relief, relieving fatigue, social functioning and emotional functioning (p<0.05). The rates of adverse events (26.4% vs 30.8%, p>0.05) and severe adverse events (5.4% vs 2.8%, p>0.05) did not differ significantly between the experimental and control groups.Conclusion: CKI significantly alleviated symptomatic radiation-induced thoracic toxicity, as well as pain, when given with chemoradiotherapy for lung cancer treatment.
Polyomic analyses of dopaminergic neurons isolated from human substantia nigra in Parkinson’s disease: An exploratory study.
Authors: ZACCARIA Affif , Malaspina Paola Antinori , Licker Virginie , Kovari Enikö , Lobrinus Johannes A , Burkhard Pierre R 
Published: April 2021

Abstract
Dopaminergic neurons of the substantia nigra pars compacta selectively and progressively degenerate in Parkinson’s disease. Until now, molecular analyses of dopaminergic neurons in PD have been limited to genomic and transcriptomic approaches, whereas, to the best of our knowledge, no proteomic or combined polyomic study examining the protein profile of these neurons, is currently available.
In this exploratory study, we used laser microdissection to extract dopaminergic neurons from 10 human SNpc samples obtained at autopsy in Parkinson’s disease patients and control subjects. Extracted RNA and proteins were identified by RNA sequencing and nano-LC-MS/MS, respectively, and the differential expression between Parkinson’s disease and control group was assessed.
Qualitative analyses confirmed that the microdissection protocol preserves the integrity of our samples and offers access to specific molecular pathways. This polyomic analysis highlighted differential expression of 52 genes and 33 proteins, including molecules of interest already known to be dysregulated in Parkinson’s disease, such as LRP2 , PNMT , CXCR4 , MAOA and CBLN1 genes, or the Aldehyde dehydrogenase 1 protein. On the other hand, despite the same samples were used for both analyses, correlation between RNA and protein expression was low, as exemplified by the CST3 gene encoding for the cystatin C protein.
This is the first exploratory study analyzing both gene and protein expression of LMD-dissected neurons from substantia nigra pars compacta in Parkinson’s disease. Data are available via ProteomeXchange with identifier PXD024748 and via GEO with identifier GSE 169755.
Spin-1/2 one- and two- particle systems in physical space without eigen-algebra or tensor product
Authors: Andoni Sokol 
Published: April 2021

Abstract
A novel representation of spin 1/2 combines in a single geometric object the roles of the standardPauli spin vector operator and spin state. Under the spin-position decoupling approximation it consists ofthree orthonormal vectors comprising a gauge phase. In the one-particle case the representation: (1) isHermitian; (2) shows handedness; (3) reproduces all standard expectation values, including the total one particlespin modulus 𝑆tot = √3ℏ/2; (4) constrains basis opposite spins to have same handedness; (5)allows to formalize irreversibility in spin measurement. In the two-particle case: (1) entangled pairs haveprecisely related gauge phases and can be of same or opposite handedness; (2) the dimensionality of the spinspace doubles due to variation of handedness; (3) the four maximally entangled states are naturally definedby the four improper rotations in 3D: reflections onto the three orthogonal frame planes (triplets) andinversion (singlet). The cross-product terms in the expression for the squared total spin of two particlesrelates to experiment and they yield all standard expectation values after measurement. Here spin is directlydefined and transformed in 3D orientation space, without use of eigen algebra and tensor product as in thestandard formulation. The formalism allows working with whole geometric objects instead of onlycomponents, thereby helping keep a clear geometric picture of ‘on paper’ (controlled gauge phase) and ‘onlab’ (uncontrolled gauge phase) spin transformations.
Modelling infectious diseases with herd immunity in a randomly mixed population
Authors: Law Kian Boon , Peariasamy Kalaiarasu M , Ibrahim Hishamshah , Abdullah Noor Hisham 
Published: April 2021

Abstract
Background The conventional susceptible-infectious-recovered (SIR) model tends to overestimate transmission dynamics of infectious diseases and ends up with total infections exceeding the threshold required for control and eradication of infectious diseases. The study aims to overcome the limitation by allowing the transmission rate of infectious disease to decline along with the reducing risk of contact infection. MethodsTwo new SIR models were developed to mimic the declining transmission rate of infectious diseases at different stages of transmission. Model A mimicked the declining transmission rate along with the reducing risk of transmission following infection, while Model B mimicked the declining transmission rate following recovery. Then, the conventional SIR model, Model A and Model B were used to simulate an infectious disease with a basic reproduction number (r0) of 3.0 and a herd immunity threshold (HIT) of 0.667 with and without vaccination. The infectious disease was expected to be controlled or eradicated when the total immunized population either through infection or vaccination reached the level predicted by the HIT. Outcomes of simulations were assessed at the time when the total immunized population reached the level predicted by the HIT, and at the end of simulations.Findings All three models performed likewise at the beginning of transmission when sizes of infectious and recovered were relatively small as compared with the population size. The infectious disease modelled using the conventional SIR model appeared completely out of control even when the HIT was achieved in all scenarios with and without vaccination. The infectious disease modelled using Model A appeared to be controlled at the level predicted by the HIT in all scenarios with and without vaccination. Model B projected the infectious disease to be controlled at the level predicted by the HIT only at high vaccination rates. At lower vaccination rates or without vaccination, the level at which the infectious disease was controlled cannot be accurately predicted by the HIT. ConclusionTransmission dynamics of infectious diseases with herd immunity can accurately be modelled by allowing the transmission rate of infectious disease to decline along with the combined risk of contact infection. Model B provides a more realistic framework for modelling infectious diseases with herd immunity in a randomly mixed population.