bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alternative fixation method for anterior cruciate ligament reconstruction in developing countries: a clinical study of modified stainless-steel implant
Authors: Sakti Muhammad , Usman Muhammad Andry , Kitta Muhammad Ihsan , Subagio Erich Svante 
Published: January 2025

Introduction: Anterior cruciate ligament (ACL) reconstruction surgery is often inaccessible to many patients with financial constraints due to the high cost of factory-made implants. In 2012, we developed a modified implant made from a 4.5-millimeter reconstruction plate to overcome this condition. This study aimed to assess the outcome of reconstruction surgery using the modified implant technique, which seemed to offer an ideal alternative for the patient as mentioned above.
Methods: This prospective study includes patients undergoing primary ACL restoration with factory-made and customized implants. Patients in both groups were assessed for functional outcome (using the Lysholm knee rating scale) and anteroposterior knee translation (measured in millimetres) at three, six, and twelve months after surgery. The Spearman's correlation and Mann-Whitney U tests were used to assess the data.
Result: Forty-four individuals with ACL reconstruction were included in this study. Twelve individuals received factory-made implants, while thirty-two patients received modified implants. The mean value of anteroposterior translation and functional results for the two groups at each monitoring period (3rd, 6th, and 12th months postoperative) did not differ significantly (p>0.05). In the modified implant group, there was a statistically significant positive correlation between anteroposterior translation and functional outcome. This correlation was moderately strong in the 6th and 12th months of the evaluation period, but at no other time did either study group show any statistical correlation.
Conclusion: Even though modified implants are less expensive than factory-made implants, the anteroposterior knee stability and functional results after ACL restoration utilizing modified implants are equivalent. The outcome of ACL reconstruction must be determined by a thorough evaluation that includes clinical assessment, functional outcome, and patient satisfaction, even if postoperative knee translation is a crucial criterion.
The relationship between microbiome and female androgenetic alopecia
Authors: Dhillon Jesryn , Putra Imam Budi , Jusuf Nelva Karmila 
Published: January 2025

Link of Video Abstract: https://youtu.be/er53Xd5h_Rs

Introduction: Hair is an important part of a woman's identity, with hair loss affecting up to 50% of women throughout their lives. Female androgenetic alopecia (FAGA) is one of the causes of nonscarring alopecia, and its prevalence varies across populations. The pathogenesis of FAGA involves genes, hormones, and microinflammation in hair follicles, with scalp microbiome as a key factor. Research on the role of the microbiome (aerobic and anaerobic bacteria) in FAGA is still limited.
Methods: This observational study with a cross-sectional design involving 30 FAGA subjects and 30 nonFAGA subjects who met the inclusion and exclusion criteria. Each patient underwent anamnesis, dermatological examination, and scalp swab collection. The data were statistically analyzed using the Kruskal-Wallis test and were considered significant with a p-value of <0.05.
Results: In the FAGA group, the most prevalent age group was 36-45 years (43.3%). The most common severity of FAGA observed is Ludwig I (66.7%). The most prevalent microbiome (aerobic bacteria) is Staphylococcus, both in the FAGA group (60%) and the non-FAGA group (30%). The most prevalent microbiome (anaerobic bacteria) is Cutibacterium, both in the FAGA group (53.3%) and the nonFAGA group (80%). The results of this study indicate a correlation between the microbiome (aerobic and anaerobic bacteria) and FAGA (p=0.028 and 0.024).
Conclusions: There is a relationship between microbiome (aerobic and anaerobic bacteria) and FAGA.
Comparison of chemical and molecular characteristics of Phyllanthus amarus and Phyllanthus urinaria species
Authors: Huynh Thi Thu Hue  , Le Tat Thanh  , Do Thi Thanh Trung  , Nguyen Thị Bich Ngoc  
Published: January 2025

Phyllanthus amarus and Phyllanthus urinaria belonging to Phyllanthaceae are the well-studied for their precious extracted compounds. Phyllanthin and hypophyllanthin provide a variety of potential health benefits for humans. Phyllanthin and hypophyllanthin biosynthesis pathway is different between P. amarus and P. urinaria. In our study, with High-performance liquid chromatography (HPLC) to quantify hypophyllanthin and phyllanthin concentration extracted from leaf and stem tissue of these two species showed the concentration of these compounds significantly varied between P. amarus .TN and P. urinaria .TN. Combine with quantitative PCR (qRT-PCR) used for measure expression of six genes that related to the biosynthesis pathway showed the expression of these genes were stronger in P. amarus than P. urinaria. DNA barcoding markers are also used for divergence analysis and phylogenetic construction. Thereby, ITS sequence was expected to be one of standard DNA barcoding markers due to its high conserved site percentage for variations analysis and phylogenetic construction.
Potential of using transcriptome sequencing data in choosing therapy for patients with colorectal cancer
Authors: Apalko S. V. , Shimansky V. S. , Kel A. , Sushentseva N. N. , Tyukavina N. V. , Kovalenko S. A. , Shcherbak S. G. 
Published: January 2025

Aim. To study the applicability of RNA (ribonucleic acid) sequencing with master regulator identification for predicting the effectiveness of targeted therapy in patients with colorectal cancer.Materials and methods. Tissue samples from three patients with colorectal cancer obtained from postoperative material were used. All patients received palliative antitumor therapy in standard regimens in accordance with the tumor location and the status of RAS and BRAF gene mutations. The transcriptome of tumor and healthy tissue of each patient was sequenced, and master regulators in the tumor tissue were analyzed.Results. A list of master regulators was found for each patient and possible therapeutic agents most suitable for suppressing the tumor process were predicted.Conclusion. The potential of computer analysis of the molecular profile of colorectal adenocarcinoma in predicting the effectiveness of therapy is shown. However, to determine the clinical potential of this technique, a study on a wider sample is required.
Assessment of the frequency and association with morbidity of DNA markers in multinational administrative divisions based on indigenous population data (based on cardiovascular diseases)
Authors: Balanovskaya E. V. , Potanina A. Yu. , Koshel S. M. , Adamov D. S. , Evsyukov I. V. , Borisova A. L. , Pokrovskaya M. S. , Meshkov A. N. 
Published: January 2025

Information on morbidity is presented in statistical reports for the entire population of multinational subjects of Russia, but population Biobanks contain information on individual peoples.Aim. To develop a technology for assessing the frequency of deoxyribonucleic acid (DNA) markers for administrative units based on indigenous population data, which will make it possible to assess the relationship between the frequency of DNA markers and morbidity.Material and methods. The Biobank of Northern Eurasia presented the frequencies of 24 DNA markers associated with cardiovascular disease (CVD) for 86 indigenous peoples of Russia (6227 DNA samples). Information on the ethnic composition of 83 Russian regions was extracted from the 2010 census, and the CVD incidence in 85 Russian regions (2020-2021) was assessed by data from the Ministry of Health of Russia.Results. The data on the gene pools of the indigenous population and the ethnic composition of Russian regions made it possible to assess the frequencies of 24 DNA markers in 85 Russian regions. The obtained frequencies allowed us to directly assess their relationship with CVD in Russia — chronic rheumatic heart diseases, cardiomyopathy, coronary artery disease, hypertension, acute myocarditis. Technology application data are presented in the form of tables and genogeographic maps of the distribution of 24 CVD DNA markers in Russian subjects, the geography of morbidity in Russian subjects for five CVDs, and the correlation of the distribution of the frequency of CVD DNA markers and the incidence of CVD among the population of Russia.Conclusion. The proposed technology for assessing the modern gene pool in Russian subjects based on the data on the gene pool of the indigenous peoples of Russia for the first time made it possible to assess the relationship between clinically significant DNA markers and morbidity in Russia.
Use of large-scale sample collections to estimate the carriage rate of miscarriage-related variants
Authors: Barbitov Yu. A. , Lazareva T. E. , Nasykhova Yu. A. , Bespalova O. N. , Glotov A. S. 
Published: January 2025

Aim. Modern large-scale biocollections and related open databases play a critical role in the development and implementation of novel approaches to prevention and diagnostics, as well as in improvement of treatment of hereditary pathologies. The aim of this study was to analyze the carriage rate of miscarriage-related variants in the Russian population presented in the RUseq database.Material and methods. The first Russian open database of genetic variants and their rate in the Russian population (RUSeq) was used as the main source of information on allele frequencies. We analyzed 270 known genetic variants described as a cause of miscarriage. A search for pathogenic variants in 18 key miscarriage-related genes was conducted.Results. We revealed that 10 out of 270 variants described as a miscarriage cause are found in the Russian population. In addition, 46 known or new potentially pathogenic variants were found in 10 key genes that are possible markers of miscarriage risk. In one case (NEB gene), the cumulative frequency of such variants exceeded 0,5%.Conclusion. The obtained results emphasize the importance of genetic databases and the need for further study of miscarriage-realted gene disorders, as well as the inclusion of identified variants in preconception genetic testing programs for couples in order to determine pregnancy planning and management.
INTEGRATIVE AND COMPLEMENTARY PRACTICES FOR PERFORMING ONCOTIC CYTOLOGY IN PRIMARY HEALTH CARE
Authors: Silva de Araújo Maria Eduarda 
Published: January 2025

Cervical cancer has high morbidity and mortality rates worldwide. The Pap smear is responsible for around 80% of early cancer detection, but there is low adherence to the test, related to cultural, social, psychological and economic factors that affect timely detection and the reduction of mortality from this cancer. The aim of this study is to analyze the use of music therapy and aromatherapy in the performance of oncotic cytology for women. This is a descriptive, exploratory study with a qualitative approach, carried out in a municipality in the interior of Rio Grande do Norte, between July and October 2023. The age group included was women aged between 18 and 64, and the sample consisted of 15 women. Data was collected using a semi-structured questionnaire. The information obtained was analyzed by content, according to Bardin. Fifteen women aged between 21 and 63 took part in the study. Results are divided into two categories: women's feelings about taking the preventive exam; participants' perceptions of the exam using the Integrative and Complementary Practices used in the study. The participants, despite knowing the importance of taking the exam periodically, for various reasons, do not carry it out as recommended. Feelings such as shame and tension are factors that influence adherence to the preventive exam and interfere with the search for services. Therefore, the use of Integrative and Complementary Practices is effective when it aims to build humanized care and form a bond between professional and patient.
Recruiting for Cultural Competency: A Content Analysis of Archives Job Postings
Authors: Smith Helen Wong , Schmitz Dawn , Shein Cyndi , Schmitz Lisa 
Published: January 2025

ABSTRACT
Professional library and archives associations recognize the value of cultural competency skills in advancing diversity, equity, inclusion, and accessibility (DEIA). This study analyzes a sample of nearly 500 archival job postings to gauge the degree to which job postings demonstrate the employers’ awareness of and commitment to cultural competency in their recruiting practices. The central finding is that only 7 percent of job ads in the sample included knowledge, skills, or abilities relating to cultural competency among the requirements for working in an archives-related position. Thus, the study strongly suggests that the value the archives profession places on cultural competency is rarely reflected in the qualifications candidates who wish to work in archives are expected to have. This problem is most evident in job ads for technical services positions, in the South and Midwest sections of the country, and in nonacademic employment sectors. The authors provide recommendations for hiring practices that further a hiring institution's commitment to DEIA through the adoption of cultural competency as a framework for recruitment and interviewing.
Real-Time Local Shear-Wave Splitting Measurement: Application to the Vicinity of the Baihetan Hydropower Plant
Authors: Han Xuefei , Li Zefeng , Liu Feng , Li Junlun , Yao Huajian 
Published: January 2025

ABSTRACT
Local shear-wave splitting (SWS) measurements can be potentially used to monitor changes in upper crustal anisotropy over time. However, its real-time implementation is not yet available due to the sophisticated measurement procedure. Here, we integrate a fully automated workflow of local SWS measurement into a 4G telemetric nodal seismometer system. This system has operated since October 2021 to monitor seismicity near the Baihetan hydropower plant in southwestern China. We validate the system by retrospective evaluation on the reliability and interpretability of the automated measurements. Most fast-wave polarization directions align with the regional maximum horizontal stress and the nearby fault trends, generally consistent with previous observations. Five stations near the Zemuhe and Xiaojiang faults show a nearly 90° flip in the fast direction during the transition from low to high water storage in the Baihetan plant. Future improvement of this real-time SWS system is to narrow down the analysis with only repeating earthquakes or earthquake clusters, which is anticipated to better facilitate time-lapse seismic monitoring of anisotropic structures and stress changes in the upper crust.
Wydzielanie petrofacji na podstawie wyników analiz NMR dla skał z różnych basenów sedymentacyjnych
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Zagórska Urszula , Hebda Kamil ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Mglej Joanna ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: January 2025

Istotnym zadaniem w celu opracowania modelu złoża i szacowania jego zasobów jest wyznaczenie petrofacji skał zdeponowanych w danym basenie sedymentacyjnym. Celem pracy było zidentyfikowanie petrofacji (ang. rock-typing) na podstawie wyników analiz magnetycznego rezonansu jądrowego (NMR). Do badań dobrano skały reprezentujące utwory czerwonego spągowca i miocenu zapadliska przedkarpackiego. Petrofacje wydzielono na podstawie specjalistycznych analiz NMR pozwalających na prawidłowe wyznaczenie porowatości dynamicznej, efektywnej i nasycenia wodą nieredukowalną. Zastosowano metodę analizy skupień z wykorzystaniem algorytmu k-średnich. Dla każdego z basenów sedymentacyjnych wydzielono po cztery petrofacje o zróżnicowanych właściwościach zbiornikowych. W przypadku skał konwencjonalnych czerwonego spągowca wykorzystano takie parametry jak porowatość całkowita (KpNMR), porowatość efektywna (Kpef), porowatość dynamiczna (Kp3), nasycenie wodą nieredukowalną w porowatości całkowitej (Swnr KpNMR), a także przepuszczalność absolutna. Kluczowe parametry najlepiej różnicujące petrofacje to porowatość dynamiczna i nasycenie wodą nieredukowaną. Natomiast skały mioceńskie podzielono w oparciu o zawartość wody w minerałach ilastych (Kp1), zawartość wody w porach <0,03 µm (Kp < 0,03), zawartość wody w porach >0,03 µm (Kp > 0,03), nasycenie wodą nieredukowalną związane z iłami (Swnr_ił) oraz nasycenie wodą nieredukowalną w porach <0,03 µm (Swnr <0,03). Najistotniejsze w wydzieleniu petrofacji okazały się nasycenie wodą nieredukowalną w porach <0,03 μm oraz zawartość wody w porach >0,03 μm. Petrofacje wydzielone w obu basenach sedymentacyjnych są zgodne z typami litologicznymi uzyskanymi na podstawie obserwacji makroskopowych i badań mineralogicznych. Do petrofacji o najkorzystniejszych parametrach (RT1) należą piaskowce średnioziarniste zarówno czerwonego spągowca, jak i miocenu. Najsłabszymi parametrami (petrofacja RT4) cechują się zlepieńce czerwonego spągowca oraz mułowce mioceńskie. Autorzy wykazali, że wyniki uzyskane metodą NMR dobrze charakteryzują najważniejsze dla eksploatacji węglowodorów parametry przestrzeni porowej skał i mogą być podstawą wydzielenia petrofacji dla skał o różnych właściwościach zbiornikowych.
Study of the properties of depressor additive “Difron-3970” and the new composition
Authors:   Azerbaijan State Oil and Industry University, Gurbanov Guseyn R. , Gasimzade Aysel V. ,   Azerbaijan State Oil and Industry University, Abbasova Leili A. ,   Azerbaijan State Oil and Industry University
Published: January 2025

This article is the first to investigate the effect of the depressor additive “Difron-3970” and the new composition with the conventional name A-1 as an original depressor against asphaltene-resin-paraffin deposits and freezing temperature in a highly paraffinic oil sample. Laboratory tests were conducted to examine the effects of “Difron-3970” depressant additive and A-1 composition on asphaltene-resin-paraffin deposits in the absence of reagents using the cold-finger method. Experiments were conducted at temperatures of 0°C, 5°C, 10°C, 15°C, 20°C, 25°C and 30°C for a period of two hours and the mass of paraffin deposits collected on the tube surface was then determined using an analytical balance. It was determined that, in all three cases, the amount of paraffin deposits increased over time, but decreased as temperature rose. The effectiveness of the “Difron-3970” depressant additive and the new composition A-1 was evaluated at concentrations of 350, 450, 550, 650, 750 g/t. In comparison to the depressant additive, the A-1 composition demonstrated superior efficacy against paraffin deposits in experiments conducted using the cold-finger method, resulting in a significant reduction. Based on the results of numerous experiments carried out using the cold-finger method, the efficiency of both reagents at the temperature of 5°C was mathematically calculated, and their effectiveness against paraffin precipitation was determined. At the optimal concentration of 750 g/t, the effectiveness rates of “Difron-3970” and the A-1 composition against paraffin precipitation over 120 minutes were 90.8% and 95%, respectively. The percentages of asphaltene, resin and paraffins in oil deposits were determined. It was observed that asphaltene and resin levels increase in deposits formed at higher temperatures in the cold-finger over extended periods, while paraffin levels decrease. The impact of “Difron-3970” and A-1 composition on the freezing point was also determined showing that, at optimal concentrations, the oil’s freezing temperature dropped from +18°C to –1°C and –5°C, respectively. Additionally, the effect of A-1 composition on the growth rate of sulfate-reducing bacteria in Postgate-B nutrient medium was studied over fifteen days. The bactericidal effect of the composition at different concentrations was calculated based on the change in the concentration of biogenic hydrogen sulfide in the medium. It was found that the bactericidal effect of A-1composition at concentrations of 350, 450, 550, 650, 750 g/t ranged from 26–62%, 29–68%, 41–77%, 48–89%, 55–98%, respectively.
Systematic Literature Review: Can the Use of the RADEC Learning Model Enhance Students' Critical Thinking Skills?
Authors: FH Yuliana , Amrina Dian Eka , Firmansyah Firmansyah 
Published: January 2025

RADEC learning model (read-answer-discuss-explain-create) strives to actively involve students in learning activities because, in the 21st-century era every student is required to have critical thinking skills which must be trained through learning activities that support students to be able to build their knowledge independently. This research aims to analyze various previous research results and development trends in using the RADEC learning model to improve students' critical thinking skills when applied in Microeconomic Theory courses. The research method used is a systematic literature review. Researchers collected 70 articles published in 2020-2024 in accredited scientific journals sourced from the database of Google Scholar related to the topic being studied. The article metadata identification process is carried out using the Mendeley application and analyzed using the application Vosviewer. Based on the systematic literature review that has been carried out, the results show that the RADEC learning model can improve critical thinking skills, communication, and collaboration skills because students are directed to be able to find solutions to the problems being studied. Apart from that, the syntax of this learning model adapts to Vygotski's social constructivism theory, that the process of building knowledge can be carried out through a process of social interaction through various discussion and collaboration activities. This learning model can be applied in multiple fields of study, including microeconomic theory courses which have contextual learning content and are very close to students' lives, so it can be said that the RADEC learning model has great potential in improving students' critical thinking skills in microeconomic theory courses.
Female Infertility: Exploring Biological Causes and Advanced Therapeutic Approaches
Authors: Dalis Noor Salman 
Published: January 2025

Female infertility is a complex subject with numerous medical factors that are potentially devastating to a woman’s fertility. It is caused by conditions such as hormonal imbalances, structural anomalies and genetic susceptibility. In the present review, focus will be made on the understanding of the biological factors of female infertility and presentation of recent developments in medical management, medical treatments, assisted reproductive technology and molecular and developmental biology. Thus, the goal of this paper is to improve knowledge and practice considerations regarding female infertility by presenting a broad perspective.
Highlights:

Causes: Hormonal, structural, genetic factors affect fertility.
Advances: Medical treatments, assisted reproduction, molecular biology progress.
Goal: Enhance knowledge and practices on female infertility management.

Keywords: Infertility in women, Women’s reproductive system, Endocrine disorders, IVF treatment, Gene therapy