bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of smart insole for cycle time measurement in sewing process
Authors: Kim Eung Tae , Kim Sungmin 
Published: January 2021

AbstractA smart insole system consisting of pressure sensors, wireless communication modules, and pressure monitoring software has been developed to measure plantar pressure distribution that appears in sewing process. This system calculates the cycle time of each operation by analyzing the real-time plantar pressure data. The operation cycle time was divided into the time done by machine and by manual and calculated by adding the two types of time. By analyzing the cycle time, it is possible to estimate the type of operation a worker is performing. The ability to calculate accurate cycle time and to manage a large volume of data is the advantage of this system. Establishing an accurate cycle time of all operations would be of great help in improving the production process, capacity planning, line efficiency, and labor cost calculation. The system is expected to be a good alternative to the conventional manual measurement process. It will also be able to meet the high demand from garment manufacturers for automated monitoring systems.
Autologous micrografts from the palatal mucosa for bone regeneration in calvarial defects in rats: a radiological and histological analysis
Authors: Kawakami Sawako , Shiota Makoto , Kon Kazuhiro , Shimogishi Masahiro , Iijima Hajime , Kasugai Shohei 
Published: January 2021

Abstract
Background
The application of dental implants is often restricted by bone volume. In such cases, bone grafts are required, although bone graft materials have some disadvantages. Therefore, other effective approaches are needed. Our previous study showed that the autologous micrograft, a dissociated cell suspension made out of palatal connective tissue grafts, promoted bone-marrow cell proliferation and differentiation under osteogenic conditions. In this study, we aimed to evaluate the effects of dissociated soft-tissue suspensions relevant to bone regeneration in animal model.

Material and methods
Twelve-week-old male Wistar rats were used in the study. Defects were created in rat calvaria, and were filled with hydrogel containing either dissociated soft-tissue suspension (test) or sucrose (control). The new bone formation was evaluated at 1 and 2 weeks after surgery (n = 16) by radiological and histological analysis.

Results
The conducted radiological analysis showed that the new bone volume was significantly greater in the dissociated soft-tissue suspension group. This finding was further confirmed by the conducted histological analysis.

Conclusions
The dissociated mucosa tissue suspension enhanced bone regeneration in vivo; thus, it is a promising potential method to aid the successful application for bone augmentation in the implant practice.
Laparoscopic resection of a metachronous secondary lymph node metastasis in the mesentery of the ileum after surgery for sigmoid colon cancer with ileum invasion: a case report
Authors: Eto Seiichiro , Omura Nobuo , Shimada Tetsuya , Takishima Teruyuki , Takeuchi Hideyuki , Kai Wataru , Kodera Keita , Matsumoto Tomo , Hirabayashi Tsuyoshi , Kawahara Hidejiro 
Published: January 2021

Abstract
Background
Extended excision of the permeation organ neighborhood is often performed in locally invasive colon cancer, and it is reported to have a survival benefit. In addition, some cases of secondary lymph node metastases in a permeation organ were reported. However, they are reports of synchronous secondary lymph node metastases, not metachronous secondary lymph node metastases. To the best of our knowledge, there are no cases of metachronous secondary lymph node metastases after the resection of a primary colorectal cancer in PubMed.

Case presentation
The case was a 67-year-old man who underwent colonoscopy because of weight loss. Sigmoid colon cancer with all circumference-related stenosis was found by examination, and the patient was transferred to our hospital for the purpose of scrutiny and treatment. The small intestine ileus caused by the invasion of sigmoid colon cancer developed after the transfer. Laparoscopic high anterior resection and extended excision of small intestine segmental resection was performed after the intestinal tract decompression with a nasal ileus tube. Histopathological analysis revealed a pathological diagnosis of pT4b (ileal submucosal invasion) N0 (0/11) M0 f Stage II, tub2, ly1, v2, PN0. Although adjuvant chemotherapy with capecitabine after the operation was planned for half a year, treatment was suspended in the first course by the patient’s self-judgment. No recurrence was observed for a year after the operation, but metastasis recurrence in the para-aortic lymph node was found by a computed tomography (CT) one and a half years after the operation. 18 F-fluorodeoxyglucose (FDG) positron emission tomography revealed that FDG was accumulated only in the para-aortic lymph node. Laparoscopic metastasis lymphadenectomy was performed due to the diagnosis of metachronous metastasis to the para-aortic lymph node alone. Intraoperative findings revealed that lymph node metastasis occurred in the mesentery of the ileum. No adjuvant treatment was done after the secondary operation, and he is still alive with no recurrence 1 year and 9 months after the operation.

Conclusions
We report a rare case of a laparoscopic resection of a metachronous secondary lymph node metastasis in the mesentery of the ileum after surgery for sigmoid colon cancer with ileum invasion.
Adherence to self-managed exercises for patients with persistent subacromial pain: the Ad-Shoulder feasibility study
Authors: Major Daniel H. , Grotle Margreth , Littlewood Chris , Brox Jens Ivar , Matre Dagfinn , Gallet Heidi V. , Røe Yngve 
Published: January 2021

Abstract
Background
Exercise is recommended for patients with subacromial pain. It has been suggested that good exercise adherence improves clinical outcomes. Despite this, little attention has been paid to the need for behavioural frameworks to enhance adherence to home exercise programmes for patients with subacromial pain.

Methods
A feasibility study with pre-post design was used. Participants aged > 18 years, with subacromial pain, who had received conservative treatment during the past 6 months, were recruited. The Ad-Shoulder intervention consisted of 1–5 individual sessions provided over 3 months and was based on 5 self-management skills, which aimed to enhance the patients’ self-efficacy and adherence to self-managed exercises. The primary objectives were assessed according to predefined progression criteria: (1) the recruitment rate (10 patients enrolled within 12 weeks), (2) follow-up rate (≥ 80% on all self-reported measures), (3) objective physical activity measures (≥ 80% of participants would contribute valid data at each time point), (4) adherence with the self-managed exercises (≥ 80% of the participants would adhere to ≥ 80% of the assigned home exercise programme), (5) fidelity of the delivery of the intervention (the therapists delivered the intervention according to the protocol) and (6) adverse events (< 30% would report adverse events (including mild)). The results were reported using descriptive statistics.

Results
Eleven patients were recruited during 16 weeks. Ten patients completed the self-reported measures at baseline and week 12. Objective physical activity measures were successfully obtained for 100% (11/11) at baseline, 64% (7/11) at week six and 82% at week 12. Fifty-five percent (6/11) of the participants satisfactorily completed at least 80% of their home exercise programme. All sessions were delivered according to the protocol. None of the patients reported any adverse events.

Conclusions
Objective physical activity data measures at baseline and week 12, follow-up, the physiotherapists’ fidelity to the intervention and adverse events met our pre-specified progression criteria. Recruitment and adherence to the self-managed exercise programme were both below the anticipated level. Further intervention development is necessary to understand whether adherence to the self-managed exercises could be enhanced and additional methods of recruitment would need to be considered, including additional recruitment sites, in any planning for a future main trial.

Trial registration
ClinicalTrials.gov, NCT04190836, Registered December 9, 2019—retrospectively registered
Healthcare disparities in cardio oncology: patients receive same level of surveillance regardless of race at a safety net hospital
Authors: Chen Crystal B. , Dalsania Raj K. , Hamad Eman A. 
Published: January 2021

Abstract
Background
Cardiotoxicity remains a dreaded complication for patients undergoing chemotherapy with human epidermal growth factor (HER)-2 receptor antagonists and anthracyclines. Though many studies have looked at racial disparities in heart failure patients, minimal data is present for the cardio-oncology population.

Methods
We queried the echocardiogram database at a safety net hospital, defined by a high proportion of patients with Medicaid or no insurance, for patients who received HER2 receptor antagonists and/or anthracyclines from January 2016 to December 2018. Patient demographics, clinical characteristics, and treatment outcomes were collected. Based on US census data in 2019, home ZIP codes were used to group patients into quartiles based on median annual household income. The primary end point studied was referral rate to cardiology for patients undergoing chemotherapy.

Results
We identified 149 patients who had echocardiograms and also underwent treatment with HER2 receptor antagonists and/or anthracyclines, of which 70 (47.0%) were referred to the cardio-oncology program at our institution. Basic demographics were similar, but white patients were more likely to live in ZIP codes with higher income quartiles (p < 0.00001). Comparing between racial groups, there was no statistical difference in the percentage of patients that had a reduction in ejection fraction (EF) (p = 0.75). There was no statistical difference between racial groups in the number of cardiology or oncology appointments attended, number of appointments cancelled, average number of echocardiograms received, additional cardiac imaging received. Black patients were more likely to receive ACEI/ARB post chemotherapy (p = 0.047). A logistic regression model was created using race, age, gender, insurance, income quartile by home ZIP code, comorbidities (hypertension, hyperlipidemia, coronary artery disease, arrhythmia, diabetes mellitus, smoking, family history, age > 65), procedures (coronary stents, cardiac surgery), medications pre-chemotherapy, cancer type, cancer stage, and chemotherapy. This model found that there was an increased referral rate among patients from higher income quartiles (p = 0.017 for quartile 3, p = 0.049 for quartile 4), patients with a history of hypertension (p < 0.0001), and patients with breast cancer (p = 0.02).

Conclusions
The results of this study suggest that patients of our cardio-oncology population at a safety net hospital receive the same level of surveillance and treatment, and develop drop in ejection fraction at similar rates regardless of their race. However, patients that reside in ZIP codes associated with higher income quartiles, with hypertension, and with breast cancer, are associated with increased rate of referral.
The additive role of dynamic contrast-enhanced and diffusion-weighted MR imaging in preoperative staging of breast cancer
Authors: Hashem Lamiaa Mohamed Bassam , Sawy Yasmine Ahmed Elsayed , Kamal Rasha Mohamed , Ahmed Soha Mohamed , elmesidy Dalia Salaheldin 
Published: January 2021

Abstract
Background
In women with diagnosed breast cancer, accurate loco-regional staging and preoperative examination are of utmost importance for optimal patient management decisions. MRI may be warranted for correct preoperative staging as recommended from international guidelines. DWI-MRI can be combined with CE-MRI to assess more functional data. So we aimed to evaluate the performance of CE-MRI and qualitative DWI-MRI in preoperative loco-regional staging of malignant breast lesions as regards the local extension of the disease and axillary lymph node status, beyond standard assessment with mammography and ultrasound. This prospective study included 50 female patients with pathologically proven malignant breast lesions (BIRADS VI) coming for preoperative staging. Full-field digital mammography (FFDM) and ultrasound, CE-MRI, and DWI-MRI findings were compared for all patients, and the findings were evaluated independently. Results were then correlated to postoperative histopathology.

Results
Fifty women with pathologically proven malignant breast lesions (BIRADS VI) were enrolled in this study; the mean age of this study population was 43.25 years. The 50 patients were divided into 2 groups: 37/50 (74%) underwent upfront surgery and 13/50 (26%) received neoadjuvant therapy before surgery. All patients performed DCE and DWI-MRI breast. Among patients who underwent upfront surgery, DCE-MRI showed the highest correlation with the postoperative pathology size and the overall sensitivity regarding multiplicity. Regarding patients who received neoadjuvant therapy, DCE-MRI was found to have the highest correlation with the postoperative pathology concerning lesion size and multiplicity after completion of the neoadjuvant chemotherapy cycles.

Conclusion
CE-MRI can accurately map lesion extension and detect multifocality/multicentricity, thus tailor surgical management options (either conservative surgery or mastectomy). Qualitative DWI can be combined with ultrasonography for better evaluation of the axillary nodal status.
Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila
Authors: Hebbar Sarita , Lehmann Malte , Behrens Sarah , Hälsig Catrin , Leng Weihua , Yuan Michaela , Winkler Sylke , Knust Elisabeth 
Published: January 2021

ABSTRACT
Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery. Yet, how defects in splicing factor genes are linked to the aetiology of the disease remains largely elusive. To explore possible mechanisms underlying retinal degeneration caused by mutations in regulators of the splicing machinery, we induced mutations in Drosophila Prp31, the orthologue of human PRPF31, mutations in which are associated with RP11. Flies heterozygous mutant for Prp31 are viable and develop normal eyes and retina. However, photoreceptors degenerate under light stress, thus resembling the human disease phenotype. Degeneration is associated with increased accumulation of the visual pigment rhodopsin 1 and increased mRNA levels of twinfilin, a gene associated with rhodopsin trafficking. Reducing rhodopsin levels by raising animals in a carotenoid-free medium not only attenuates rhodopsin accumulation, but also retinal degeneration. Given a similar importance of proper rhodopsin trafficking for photoreceptor homeostasis in human, results obtained in flies presented here will also contribute to further unravel molecular mechanisms underlying the human disease.
This paper has an associated First Person interview with the co-first authors of the article.
Ca2+ elevations disrupt interactions between intraflagellar transport and the flagella membrane in Chlamydomonas
Authors: Fort Cecile , Collingridge Peter , Brownlee Colin , Wheeler Glen 
Published: January 2021

ABSTRACT
The movement of ciliary membrane proteins is directed by transient interactions with intraflagellar transport (IFT) trains. The green alga Chlamydomonas has adapted this process for gliding motility, using retrograde IFT motors to move adhesive glycoproteins in the flagella membrane. Ca2+ signalling contributes directly to the gliding process, although uncertainty remains over the mechanism through which it acts. Here, we show that flagella Ca2+ elevations initiate the movement of paused retrograde IFT trains, which accumulate at the distal end of adherent flagella, but do not influence other IFT processes. On highly adherent surfaces, flagella exhibit high-frequency Ca2+ elevations that prevent the accumulation of paused retrograde IFT trains. Flagella Ca2+ elevations disrupt the IFT-dependent movement of microspheres along the flagella membrane, suggesting that Ca2+ acts by directly disrupting an interaction between retrograde IFT trains and flagella membrane glycoproteins. By regulating the extent to which glycoproteins on the flagella surface interact with IFT motor proteins on the axoneme, this signalling mechanism allows precise control of traction force and gliding motility in adherent flagella.
EFEITOS DA REFORMA TRABALHISTA NA JUSTIÇA DO TRABALHO: ANÁLISE DA DINÂMICA PROCESSUAL NA SEGUNDA VARA DO TRABALHO DE SANTA MARIA/RS
Authors: Libardoni Paulo José , Galia Rodrigo Wasen 
Published: January 2021

Objetivos: A Reforma Trabalhista, operada pela Lei nº 13.467/2017, trouxe modificações substanciais ao Direito Processual do Trabalho. Nesse sentido, o presente artigo destina-se a analisar tais impactos reformistas na seara processual trabalhista, mormente na dinâmica processual trabalhista, operadas na segunda Vara do Trabalho de Santa Maria/RS, que reclamam uma nova e diferenciada atuação dos profissionais que atuam na área trabalhista (advogados e contadores).Metodologia: O presente estudo constitui-se como uma sistematização de dados quantitativos da segunda Vara do Trabalho de Santa Maria apresentados pelo sistema do Tribunal Regional do Trabalho da 4º Região a partir do ano de 2012 até 2019, seguida por revisões bibliográfica e legislativa que seguem o método dedutivo. Utiliza-se de pesquisa de campo complementada por um aporte bibliográfico, legislativo e doutrinário multidisciplinar e interdisciplinar.Resultados: Várias alterações processuais trabalhistas foram operadas pela Reforma Trabalhista. Dessa forma, conclui-se que houve modificações na distribuição quantitativa das ações por rito, entretanto manteve-se constante o número total de ações ajuizadas. Contribuições: A principal contribuição desta pesquisa reside na possibilidade de se refletir e de se indagar sobre os impactos da Reforma Trabalhista nas ações judiciais que tramitam na segunda Vara do Trabalho de Santa Maria-RS (Justiça do Trabalho).
Studying accelerated cardiovascular ageing in Russian adults through a novel deep-learning ECG biomarker
Authors: Diez Benavente Ernest , Jimenez-Lopez Francisco , Attia Zachi I. , Malyutina Sofia , Kudryavtsev Alexander , Ryabikov Andrew , Friedman Paul A. , Kapa Suraj , Voevoda Michael , Perel Pablo , Schirmer Henrik , Hughes Alun D. , Clark Taane G. , Leon David A. 
Published: January 2021

Background: A non-invasive, easy-to-access marker of accelerated cardiac ageing would provide novel insights into the mechanisms and aetiology of cardiovascular disease (CVD) as well as contribute to risk stratification of those who have not had a heart or circulatory event. Our hypothesis is that differences between an ECG-predicted and chronologic age of participants (δage) would reflect accelerated or decelerated cardiovascular ageing Methods: A convolutional neural network model trained on over 700,000 ECGs from the Mayo Clinic in the U.S.A was used to predict the age of 4,542 participants in the Know Your Heart study conducted in two cities in Russia (2015-2018). Thereafter, δage was used in linear regression models to assess associations with known CVD risk factors and markers of cardiac abnormalities. Results: The biomarker δage (mean: +5.32 years) was strongly and positively associated with established risk factors for CVD: blood pressure, body mass index (BMI), total cholesterol and smoking. Additionally, δage had strong independent positive associations with markers of structural cardiac abnormalities: N-terminal pro b-type natriuretic peptide (NT-proBNP), high sensitivity cardiac troponin T (hs-cTnT) and pulse wave velocity, a valid marker of vascular ageing. Conclusion: The difference between the ECG-age obtained from a convolutional neural network and chronologic age (δage) contains information about the level of exposure of an individual to established CVD risk factors and to markers of cardiac damage in a way that is consistent with it being a biomarker of accelerated cardiovascular (vascular) ageing. Further research is needed to explore whether these associations are seen in populations with different risks of CVD events, and to better understand the underlying mechanisms involved.
Combinatorial Benders Decomposition for the Two-Dimensional Bin Packing Problem
Authors: Côté Jean-François , Haouari Mohamed , Iori Manuel 
Published: January 2021

The two-dimensional bin packing problem calls for packing a set of rectangular items into a minimal set of larger rectangular bins. Items must be packed with their edges parallel to the borders of the bins, cannot be rotated, and cannot overlap among them. The problem is of interest because it models many real-world applications, including production, warehouse management, and transportation. It is, unfortunately, very difficult, and instances with just 40 items are unsolved to proven optimality, despite many attempts, since the 1990s. In this paper, we solve the problem with a combinatorial Benders decomposition that is based on a simple model in which the two-dimensional items and bins are just represented by their areas, and infeasible packings are imposed by means of exponentially many no-good cuts. The basic decomposition scheme is quite naive, but we enrich it with a number of preprocessing techniques, valid inequalities, lower bounding methods, and enhanced algorithms to produce the strongest possible cuts. The resulting algorithm behaved very well on the benchmark sets of instances, improving on average on previous algorithms from the literature and solving for the first time a number of open instances. Summary of Contribution: We address the two-dimensional bin packing problem (2D-BPP), which calls for packing a set of rectangular items into a minimal set of larger rectangular bins. The 2D-BPP is a very difficult generalization of the standard one-dimensional bin packing problem, and it has been widely studied in the past because it models many real-world applications, including production, warehouse management, and transportation. We solve the 2D-BPP with a combinatorial Benders decomposition that is based on a model in which the two-dimensional items and bins are represented by their areas, and infeasible packings are imposed by means of exponentially many no-good cuts. The basic decomposition scheme is quite naive, but it is enriched with a number of preprocessing techniques, valid inequalities, lower bounding methods, and enhanced algorithms to produce the strongest possible cuts. The algorithm we developed has been extensively tested on the most well-known benchmark set from the literature, which contains 500 instances. It behaved very well, improving on average upon previous algorithms, and solving for the first time a number of open instances. We analyzed in detail several configurations before obtaining the best one and discussed several insights from this analysis in the manuscript.