bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
Authors: Bo Sihan , You Yong , Wang Yongwei , Zhang Yan , Bai Bing , Jiang Tao , Gao Yaxian 
Published: December 2024

Abstract

Background
Microsatellite instability (MSI) significantly impacts treatment response and outcomes in colon cancer; however, its underlying molecular mechanisms remain unclear. This study aimed to identify prognostic biomarkers by comparing MSI and microsatellite stability (MSS).

Methods
Data from the GSE39582 dataset downloaded from the Gene Expression Omnibus database were analyzed for differentially expressed genes (DEGs) and immune cell infiltration between MSI and MSS. Then, weighted gene co-expression network analysis (WGCNA) was utilized to identify the key modules, and the modules related to immune infiltration phenotypes were considered as the immune-related gene modules, followed by enrichment analysis of immune-related module genes. Prognostic signatures were derived using Cox regression, and their correlation with immune features and clinical features was assessed, followed by a nomogram construction.

Results
A total of 857 DEGs and 14 differential immune cell infiltration between MSI and MSS were obtained. Then, WGCNA identified two immune-related modules comprising 356 genes, namely MEturquoise and MEbrown. Eight signature genes were identified, namely PLK2, VSIG4, LY75, GZMB, GAS1, LIPG, ANG, and AMACR, followed by prognostic model construction. Both training and validation cohorts revealed that these eight signature genes have prognostic value, and the prognostic model showed superior predictive performance for colon cancer prognosis and distinguished the clinical characteristics of colon cancer patients. Notably, VSIG4 among the signature genes correlated significantly with immune infiltration, human leukocyte antigen expression, and immune pathway enrichment. Finally, the constructed nomogram model could significantly predict the prognosis of colorectal cancer.

Conclusion
This study identifies eight prognostic signature genes associated with MSI and immune infiltration in colon cancer, suggesting their potential for predicting prognostic risk.
Demand for Payment Services and Consumer Welfare: The Introduction of a Central Bank Digital Currency
Authors: Huynh Kim P. , Molnar Jozsef , Shcherbakov Oleksandr , Yu Qinghui (Jerry) 
Published: December 2024

Abstract
In this paper, we study how potential characteristics of the new payment instrument may affect consumer adoption and usage decisions at the point of sale. We do this by developing and estimating a structural model of payment choice, which accounts for rich heterogeneity in consumer preferences and distinguishes between adoption and usage decisions. In the model, consumers face uncertainty about acceptance decisions by merchants, who represent the opposite side of the market. We use parameter estimates to simulate introduction of a new payment instrument and to evaluate the effect of this introduction on the welfare of various demographic groups of consumers.
The Secrets of Salantai Engraving Studio: Stanisław Czerski, the Mysterious Byks, and ‘The Wrong’ Plater
Authors: Braziūnienė Alma 
Published: December 2024

In the early 19th century, the short-living Salantai Engraving Studio became an exceptional phenomenon of the culture of Lithuania: it was here that engravings with Lithuanian (Samogitian) inscriptions were being made. Its founder Stanisław Czerski (1777–1833), who also worked there for a while, was denoted by a talented personality of broad interests. He was a talented philologist, a translator, pedagogue, engraver, ethnologist, a canon of the Samogitian Cathedral Chapter, and a Doctor of Theology. The article investigates the nature of the activity of Salantai Engraving Studio: whether the engravers using the fictitious name of Byks was related to it, if this could be Albert Gorski (1808–1860), the owner of Salantai Manor, with whom of the Plater family Stanisław Czerski was maintaining friendly relationships, as well as other debatable issues which, so far, have been presented in historiography in a multitude of different ways. The objective of this article is to specify some claims on Stanisław Czerski as a promoter of culture and Salantai Engraving Studio while challenging a number of misconceptions that previously were firmly established in historiography, while also providing novel insights in terms of explicating pseudonyms and other relevant issues. The sources of this research are publications in encyclopedias, reference publications and scholarly articles, while also touching upon the relevant archival sources in a number of memory institutions. This research employs content and source analysis methods along with the historical comparative method. The article raises a hypothesis that Salantai Studio was making not only copper engravings, but also publishing lithographs. Meanwhile, the Byks alias appears to have been used by two different engravers. The exact date of birth of Albert Gorski, the owner of Salantai Manor, and a disciple of Stanisław Czerski has been established. Archival sources were used to determine some facts of the biography of Albert Gorski, and his relationship with Stanisław Czerski has been outlined. The claim by Vaclovas Biržiška on the friendship between Stanisław Czerski and Jurgis Plateris (1810–1836) has been disproven. Hopefully, this article will serve for further more extensive research on Salantai Engraving Studio and its founder Stanisław Czerski.
Effect of animal fat replacement by oleogel as an innovative strategy on the composition of fatty acids, technological, oxidative, and sensory properties in hamburgers
Authors: Roufegarinejad L. , Khiabani A. Habibzadeh , Kheiri F. , Gharekhani M. , Toker O. Said , Karimidastjerd A. , Alizadeh A. 
Published: December 2024

AbstractThe present work evaluates the effect of the incorporation of 6% carnauba wax (CW) and 7% monoglyceride (MG) oleogels for production of a healthy lipid mixture (linseed and sunflower oils) oleogels as a fat replacer at 30, 50, and 70% in hamburger formulation. Hamburgers' fatty acid composition, cooking loss, fat absorption, and texture and oxidative stabilities were evaluated. Incorporation of oleogels in hamburger formulation resulted in a significant decrease (P < 0.05) in amounts of saturated fatty acids (SFAs), as well as a decrease in the ratio of omega-6 to omega-3 fatty acids and atherogenic indices, and an increase in linoleic and linolenic acids (PUFAs) content. Substitution of animal fat with CW and MG based oleogels improved the manufactured hamburgers' quality by reducing cooking loss and fat absorption. In addition, the use of oleogel improved the oxidative stability during the storage of burgers. The lower hardness of oleogels compared to animal fats, as well as their nutritional and technological properties, make them a desirable candidate for animal fat substitution.
Antimicrobial activity of a new compound of 1,2,4-triazole derivatives against pathogens of poultry bacterial diseases
Authors: Vashchyk Yevheniia , Safonov Andriy , Zakhariev Andriy , Shapovalova Olga , Demianenko Denys 
Published: December 2024

The aim: study of the antimicrobial activity of a new compound of 1,2,4-triazole derivatives against pathogens of poultry bacteriosis.
Materials and methods. Research was conducted on the bactericidal activity of a new compound of 1,2,4-triazole derivatives against pathogens of poultry bacteriosis. Dimethylsulfoxide was used to dissolve the ASP compound. In order to study the bactericidal activity of the compounds, reference and field strains of S. typhimurium, E. coli, St. aureus, P. aeruginosa, P. vulgaris, K. pneumoniae, L. monocytogenes, E. faecalis were used. The study of the minimum inhibitory concentration (MIC) was carried out by the method of serial dilution in Muller-Hinton broth, the minimum bactericidal concentration (MBC) - by seeding from transparent tubes on Petri dishes with differential nutrient media.
The results. The inhibitory effect of the ASP compound at a concentration of 62.5 μg/ml against E. coli, L. Monocytogenes, E. faecalis, and at a concentration of 125 μg/ml against S. typhimurium, E. coli, St. aureus, P. aeruginosa, P. vulgaris, K. pneumoniae, L. monocytogenes, E. faecalis was established. The bactericidal effect of the ASP compound was detected at a concentration of 62.5 μg/ml against L. monocytogenes, at a concentration of 125 μg/ml - against E. coli, St. aureus, L. monocytogenes and E. faecalis. The ASP compound at a concentration of 250 μg/ml has the inhibitory and bactericidal effect on all tested reference and field strains of poultry bacteriosis pathogens.
Conclusions. A new synthesized compound of 1,2,4 triazole derivatives of ASP exhibits the inhibitory effect at a concentration of 125 μg/ml - in relation to E. coli, St. aureus, L. monocytogenes and E. faecalis and the bactericidal effect against bacteriosis pathogens S. typhimurium, E. coli, St. aureus, P. aeruginosa, P. vulgaris, K. pneumoniae, L. monocytogenes, E. faecalis at a concentration of 250 μg/ml
TP in Oshiwambo subject nominalizations
Authors: Lee Soo-Hwan , Ndapo Olivia 
Published: December 2024

Subject nominalizations have been argued to be deprived in verbal structure and lack extended verbal projections such as TP (Baker &amp; Vinokurova 2009). We show that TP is realized in Oshiwambo (R20, Bantu) subject nominalizations. Other functional elements associated with passive, causative, and applicative constructions are observed in Oshiwambo subject nominalizations. Anaphor binding is also attested. We further demonstrate that subject nominalizations are different from reduced and headless relative clauses. An implication of this work is that Oshiwambo subject nominalizations are best described under a phrasal layering approach (Alexiadou &amp; Schäfer 2010, among others) and that their syntactic size can be as articulated as a finite clause.
Type of generalized mathematical model for describing large hot deformations
Authors: Belomyttsev M. Yu. 
Published: December 2024

The relationship between temperature-strain-force parameters in hot deformation processes is important in the forming practice. Of the two options for searching and describing such relationships (based on physical laws and mathematical techniques), in some cases the method of mathe­matical search for the desired dependence turns out to be simpler. This is exactly the path implemented in the abstracted message. For this propose, a matrix of initial data was created from digitized strain diagrams of the samples made of heat-resistant 1Cr12Ni3Mo2VNbN 12 % Cr steel deformed to a true deformation degree of ~1 at 1253 – 1453 K and a compression rate of 0.01 – 10 s–1 in true coordinates (φ and S). In this matrix, for each point of the experimental deformation diagram the stress S, the deformation degree φ, the deformation rate φ′, and the temperature T were indicated. The required mathematical model has a multiplicative form, which made it possible to bring it into a linear form by taking logarithms and to search for coefficients with the factors (and after logarithm, with terms in a polynomial) to use standard Mathcad operators with calculation algorithms based on the least squares method. The quality of the model was assessed quantitatively by calculating Q – the sum of squared differences between the calculated and experimental stress values ​​with its normalization to the average stress value S from the entire array. For the found best form of relationship S = f (φ, φ′, T) as \(\log (S) = A + B\log (\varphi ) + C{[\log (\varphi )]^2} + D{[\log (\varphi )]^3} + E\log (\varphi ') + F\log (\varphi )\log (\varphi ') + G\frac{\varphi }{{\varphi '}} + \frac{{H + K\varphi + M\log (\varphi ) + N\log (\varphi ') + P\log (\varphi )\log (\varphi ')}}{T}\) the Q value was 6 % of Sav = 130 MPa. It was established that the found type of mathematical description of hot deformation is applicable to the analysis of hot deformation processes of a wide variety of metal materials, while the accuracy of the predictive characteristics of the deformation stress is 3 – 11 %.
DETENTION CONTROL IN PRE-TRIAL CRIMINAL PROCEEDINGS
Authors: Zalužinska Inga 
Published: December 2024

Detention is the most severe security measure, which is applied to the suspect or the accused person in pre-trial criminal proceedings. Due to the significiantly restrictive nature of human rights, a systematic review of the legality of detention is necessary. Control over the application of detention is regulated in Article 281 of the Criminal Procedure Law, imposing the obligation on the investigating judge to assess the need for further application of detention in pre-trial criminal proceedings.In the study, the author highlights the importance of detention control in pre-trial criminal proceedings. The author analyzes the nature of the detention control institute, examines the legal subjects exercising the authorities and rights of detention control, identifies the problematic issues of detention control implementation.
Direct lateral interbody fusion with indirect decompression of the spinal roots in patients with degenerative lumbar spinal stenosis
Authors: Isakov I. D. , Sanginov A. J. , Akhmetyanov Sh. A. , Mushkachev E. A. , Sorokin A. N. , Peleganchuk A. V. 
Published: December 2024

Introduction Degenerative spine conditions involve the gradual loss of normal structure of the spine among the population and remain a common form of work-limiting health condition in 80 % of the population. The demand for surgical interventions will remain high in an aging population to improve quality of life. Lumbar spinal decompression and stabilization are produced using ventral, posterior and lateral approaches. Lateral lumbar interbody fusion (LLIF) is used for treatment of degenerative lumbar stenosis having advantages over surgical interventions from other approaches.The objective was to determine the prospects of LLIF as an independent decompressive and stabilizing surgical intervention using literature data.Material and methods This article presents generalized information from Russian and foreign publications on LLIF with indirect decompression of the lumbar nerve roots. The original literature search was conducted on key resources including Scientific Electronic Library (www.elibrary.ru), the National Library of Medicine (www.pubmed.org) and Scopus using keywords: direct lateral interbody fusion, indirect decompression of the spinal nerve roots, predictors, lateral lumbar interbody fusion, direct lumbar interbody fusion, extreme lumbar interbody fusion, indirect decompression. The review included 60 articles published between 1998 and 2023 inclusive.Results and discussion After performing LLIF, some patients experience indirect decompression of the spinal nerve roots to prevent epidural fibrosis, injury to the dura mater and spinal nerve roots. Identifying a model of patients with degenerative spinal stenosis who can undergo LLIF as an independent decompressivestabilizing surgical intervention without additional instrumentation can improve the effectiveness of surgical treatment.Conclusion LLIF was shown to be an effective method for indirect decompression of spinal nerve roots at the intervertebral foramina. Indirect decompression of the spinal nerve roots in the spinal canal may fail and the choice of a LLIF candidate (a single surgical intervention) remains open.
Stenosing tenosynovitis
Authors: Kotelnikov G. P. , Pankratov A. S. , Nikolaenko A. N. , Borisov A. P. , Klyuchnikov A. S. , Piskun V. V. , Knyazev N. A. , Lukshin D. V. 
Published: December 2024

Introduction Stenosing tenosynovitis or trigger finger is a common cause of hand disability. With the 174year history of the condition, treatment strategy and new minimally invasive surgical approaches are essential for researchers around the world.The objective was to determine the current treatment options of the stenosing tenosynovitis using the Russian and foreign literature.Material and methods The original literature search was conducted on key resources including Scientific Electronic Library (www.elibrary.ru), the National Library of Medicine (www.pubmed.org) and MedLine. Seventy contributions were identified published for the last 10 years.Results and discussion Treatment of stenosing ligamentitis can be initiated depending on the stage of the disease, the duration, relapses or complications, comorbidities. Conservative orthopaedic treatment includes joint immobilization and/or corticosteroid injections. Although percutaneous dissection of the annular ligament is minimally invasive and has advantages of less tissue trauma, shorter recovery time, absence of painful scars open ligamentotomy can help to minimize complications and relapses of the disease.Conclusion Conservative treatment of trigger finger is effective in 47 to 93 % and surgical procedures are practical in 94–99 %. Surgical treatment can be employed with failure of conservative treatment and has been shown to be effective and with a low rate of complications and relapses.
Coping and Thriving: Undocumented Latino Students in Higher Education
Authors: Jimenez-Arista Laura E. , Hahnke Melissa , Caldera Karla , Koro Mirka 
Published: December 2024

Abstract
Undocumented students in higher education experience multiple barriers as well as cultural, social, legal, financial, and campus-life stressors. Despite these challenges, many of them learn to deal with these difficulties and achieve their academic goals. In this qualitative study, we collected data from five undocumented students in higher education (graduate and undergraduate programs) and developed a model that illustrates their methods of coping. Using constructivism as an overarching theoretical perspective, we developed a framework that depicts their coping strategies, which consists of four major coping categories: (a) Interpersonal Coping, (b) Affective Coping, (c) Cognitive Coping, and (d) Active Coping. Through this analysis, we captured the participants’ individual expressions of coping and examined the motivations and functions of these coping strategies (strategies were used as an outlet for tension or to implement solutions). This research confirms strategies examined in the literature (interpersonal, affective, and active coping) and examines cognitive coping as a set of strategies (reframing, acceptance, self-affirmations, and wishful thinking) among undocumented students that has received less attention. Overall, these findings can provide information for professionals (including educators and counselors) to better support the educational and emotional needs of these students and help them succeed in their academic journey.
Nuevo procedimiento para el mantenimiento de las subestaciones de interiores para lograr su eficiencia operacional
Authors: Ruano-González Carlos 
Published: December 2024

Las subestaciones eléctricas de media tensión son partes fundamentales de los grupos de generación distribuida, los cuales juegan un papel importante en la disponibilidad de los Sistema Eléctrico de Potencias. Estas por su naturaleza, cambia la concepción a la hora de analizar las técnicas de mantenimiento respecto a las que se conocen tradicionalmente o usadas normalmente en las subestaciones convencionales de exteriores, por lo que la gestión de una metodología para su realización debe estar bien concebida y fundamentada. Sobre esta línea de trabajo se dirige el análisis y concepción de los mantenimientos a las celdas eléctricas que conforman una subestación de media tensión de interiores, que se utilizan en los grupos de generación distribuida. Donde para realizar los mantenimientos, se utilizan los métodos y procedimientos aplicados a las subestaciones de exteriores en su gran mayoría, basado en la aplicación del mantenimiento preventivo, después de análisis y estudios realizados por las frecuentes averías que se suceden, comprometiendo el servicio de energía eléctrica a los usuarios y existiendo daños a los equipos primarios que componen las celdas eléctricas, se hace necesario implementar una metodología para el diagnóstico y la gestión del mantenimiento, donde se conjuguen otros tipos de mantenimientos como los preventivos y predictivos, utilizaremos para su control y evaluación el mantenimiento a subestaciones eléctricas mediante indicadores de clase mundial, proponiendo una metodología que logra mejorar su eficiencia operacional.
Intérêt des drêches dans l’alimentation des canards et des oies
Authors: BAÉZA Élisabeth 
Published: December 2024

Les drêches sont des coproduits issus de la production industrielle d’éthanol. Elles sont utilisées essentiellement dans l’alimentation des bovins, des porcs, des volailles et des poissons. Les œufs et la viande de canard et d’oie représentent un marché important, en particulier en Asie, mais peu d’études ont été publiées sur la possibilité d’utiliser des drêches dans leur alimentation. Cette revue présentera les particularités nutritionnelles des drêches et les intérêts et limites de leur utilisation dans l’alimentation des volailles. Puis, les données acquises sur l’utilisation des drêches dans l’alimentation des canards et des oies en croissance ou en ponte et leurs effets sur les performances de production et la qualité des produits seront détaillées. Les drêches de maïs incorporées à un niveau maximal de 25 % dans les régimes croissance et finition des canards et des oies n’ont pas d’impact négatif sur les performances de croissance, la composition de la carcasse et la qualité de leur viande. Le taux d’incorporation des drêches de sorgho dans l’aliment destiné aux palmipèdes ne devrait pas excéder 15 %. Pour les canes en ponte, il est possible d’incorporer 18 % de drêches de maïs dans l’aliment. Les drêches de maïs ont des teneurs élevées en acides gras insaturés, en particulier les acides oléique et linoléique (20 et 38 g/kg, respectivement). Leur incorporation dans les aliments induit donc une modification de la composition en acides gras de la viande et des œufs et accroît leur sensibilité à l’oxydation. Ces drêches sont également riches en xanthophylles qui accentuent la couleur jaune des œufs. La supplémentation conjointe des aliments avec des enzymes de type xylanases et β-glucanases améliore la digestibilité des drêches qui ont des teneurs élevées en polysaccharides insolubles. Cependant, pour utiliser les drêches, il est important d’adapter la formulation des aliments, en particulier la supplémentation en acides aminés, notamment en lysine, et de contrôler régulièrement les teneurs en mycotoxines des lots de maïs et de drêches pour éviter les effets délétères de ces contaminants sur la santé et les performances de croissance ou de ponte des animaux.