bluuebunny/crossref_metadata_2025_split huggingface dataset:
A long-term cross-sectional study with modified forgotten joint score to assess the perception of artificial joint after total knee arthroplasty
Authors: Chithartha Karthik , Nair Anjaly S. , Thilak Jai 
Published: March 2021

Background and purpose: The ultimate goal for an arthroplasty surgeon is to provide the patient a joint that feels more like a natural joint. The Modified Forgotten Joint Score (MFJS) is a newly introduced functional scoring system that has a superior ability to assess this property among arthroplasty patients. The objective of this study is to evaluate the long-term temporal association of the MFJS and total knee arthroplasty (TKA). Methods: We assessed 360 patients post TKA with MFJS questionnaire. The patient groups were distributed at follow-up intervals of 3 weeks (n = 55), 6 months (n = 45), 1 year (n = 57), 2 years (n = 40), 3 years (n = 49), 5 years (n = 49), 7 years (n = 39), and 10 years (n = 26). Higher score suggests a forgotten artificial joint. Results: Post-operative mean MFJS scores were 64.4 ± 7.6 at 3 weeks, 87.7 ± 5.6 at 6 months, 89.2 ± 3.1 at 1 year, 89.9 ± 2.6 at 2 years, 89.4 ± 3.2 at 3 years, 89.1 ± 4 at 5 years, 84.5 ± 8.8 at 7 years, and 82.7 ± 11.9 at 10 years. The score at 3 weeks was significantly lesser than the average scores at other follow-up intervals. The score at 6 months was significantly higher compared to the score at 10 years. The average score at 1 year, 2 years, 3 years, and 5 years were significantly higher compared to the average score at 7 years and 10 years. Conclusion: The trend of the MFJS score was found to drastically improve from 3 weeks to 6 months and peak in 2 years after which the score tends to attain a plateau up to 5 years following which there is a decline in the score at 7- and 10-years post-surgery. Age did not have an influence on the variation in functional score in any of the follow-up groups. MFJS has a strong positive correlation with the well-recognised KOOS scoring system.
Level of evidence: IV
Association Between Metabolic Syndrome and All-Cause Mortality in Patients with Acute Coronary Syndrome: A Meta-Analysis
Authors: Yang Yong , Shen Haili , Jin Zhigeng , Ma Dongxing , Zhao Qing , Zhang Xuyi 
Published: March 2021

AbstractThe association between metabolic syndrome (MetS) and survival outcome after acute coronary syndrome (ACS) remains controversial. This meta-analysis sought to examine the association of MetS with all-cause mortality among patients with ACS. Two authors independently searched PubMed and Embase databases (from their inception to June 27, 2020) for studies that examined the association of MetS with all-cause mortality among patients with ACS. Outcome measures were in-hospital mortality and all-cause mortality during the follow-up. A total of 10 studies involving 49 896 ACS patients were identified. Meta-analysis indicated that presence of MetS was associated with an increased risk of long-term all-cause mortality [risk ratio (RR) 1.25; 95% CI 1.15–1.36; n=9 studies] and in-hospital mortality (RR 2.35; 95% CI 1.40–3.95; n=2 studies), respectively. Sensitivity and subgroup analysis demonstrated the credibility of the value of MetS in predicting long-term all-cause mortality. MetS is associated with an increased risk of long-term all-cause mortality among patients with ACS. However, additional studies are required to investigate the association of MetS with in-hospital mortality.
Typical Imaging Patterns in COVID-19 Infections of the Lung on Plain Chest Radiographs to Aid Early Triage
Authors: Kasper Judith , Decker Josua , Wiesenreiter Katharina , Römmele Christoph , Ebigbo Alanna , Braun Georg , Häckel Thomas , Schwarz Florian , Wehler Markus , Messmann Helmut , Kröncke Thomas J. , Scheurig-Münkler Christian 
Published: March 2021

Purpose To evaluate imaging patterns of a COVID-19 infection of the lungs on chest radiographs and their value in discriminating this infection from other viral pneumonias.
Materials and Methods All 321 patients who presented with respiratory impairment suspicious for COVID-19 infection between February 3 and May 8, 2020 and who received a chest radiograph were included in this analysis. Imaging findings were classified as typical for COVID-19 (bilateral, peripheral opacifications/consolidations), non-typical (findings consistent with lobar pneumonia), indeterminate (all other distribution patterns of opacifications/consolidations), or none (no opacifications/consolidations). The sensitivity, specificity, as well as positive and negative predictive value for the diagnostic value of the category “typical” were determined. Chi² test was used to compare the pattern distribution between the different types of pneumonia.
Results Imaging patterns defined as typical for COVID-19 infections were documented in 35/111 (31.5 %) patients with confirmed COVID-19 infection but only in 4/210 (2 %) patients with any other kind of pneumonia, resulting in a sensitivity of 31.5 %, a specificity of 98.1 %, and a positive and negative predictive value of 89.7 % or 73 %, respectively. The sensitivity could be increased to 45.9 % when defining also unilateral, peripheral opacifications/consolidations with no relevant pathology contralaterally as consistent with a COVID-19 infection, while the specificity decreases slightly to 93.3 %. The pattern distribution between COVID-19 patients and those with other types of pneumonia differed significantly (p < 0.0001).
Conclusion Although the moderate sensitivity does not allow the meaningful use of chest radiographs as part of primary screening, the specific pattern of findings in a relevant proportion of those affected should be communicated quickly as additional information and trigger appropriate protective measures.
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Prädiktoren des Entlassmodus aus forensischer Suchtbehandlung – Erster Teil einer Übersichtsarbeit zu Erfolgsdeterminanten einer Unterbringung gemäß § 64 StGB
Authors: Querengässer Jan , Baur Alexander 
Published: March 2021

Zusammenfassung
Hintergrund Ehe eine forensische Suchtbehandlung gemäß § 64 StGB gerichtlich angeordnet werden kann, ist eine Erfolgsprognose zu stellen und zu bejahen. Der Suche nach entsprechenden Prädiktoren für eine „hinreichend konkrete“ Erfolgsaussicht widmeten sich in den vergangenen Jahren einige Studien. Neben der Legalbewährung stellt der Entlassmodus aus der Maßregel, d.h. ob eine reguläre Entlassung auf Bewährung oder eine Erledigung der Unterbringung wegen Aussichtslosigkeit erfolgt, das zentrale Erfolgskriterium forensischer Suchtbehandlung dar.
Zielsetzung Als erster Teil einer zweiteiligen Gesamtschau zu Erfolgsdeterminanten forensischer Suchtbehandlung soll die vorliegende Arbeit einen Überblick über die aktuelle Befundlage zu Prädiktoren des Entlassmodus geben, sowohl bei univariater Betrachtung als auch bei multivariater.
Methodik Basierend auf systematischer Literaturrecherche werden dabei die Ergebnisse von 16 empirischen Studien aus dem Zeitraum 1999–2019 vertieft aufbereitet und zusammengefasst. Univariate Befunde zu einzelnen Prädiktoren werden in einer Überblickstabelle dargestellt, multivariate Ergebnisse etwa zu „typischen“ Behandlungsabbrechern zusammengefasst.
Ergebnisse Auf univariater Ebene ergeben sich überwiegend heterogene Befunde, als einigermaßen sichere Prädiktoren können die Faktoren Persönlichkeitsstörung und psychopathy sowie „statische“ anamnestische Faktoren wie die kriminelle Vorbelastung gelten. Multivariat weist insbesondere die Kombination aus frühem Delinquenzbeginn, problematischem sozialen und/oder beruflichen Hintergrund bzw. Bildungshintergrund, einhergehend mit bestimmten Persönlichkeitskomponenten, ein sehr hohes Risiko für eine vorzeitige Beendigung der Unterbringung auf.
Schlussfolgerung Der aktuelle Forschungsstand kann keine erschöpfende Antwort auf die Frage nach entscheidenden Determinanten von Erfolg oder Misserfolg von Behandlungen in Entziehungsanstalten – gemessen am Entlassmodus – geben. Die Übersicht kann forensisch-psychiatrische Sachverständige aber bei der Stellung einer reliablen Prognose der Behandlungsaussicht unterstützen.
Therapie und Outcome von Neugeborenen mit kongenitaler Zwerchfellhernie und angeborenen Herzfehlern
Authors: Balks Julian , Mueller Andreas , Herberg Ulrike , Geipel Annegret , Gembruch Ulrich , Schroeder Lukas , Dewald Oliver , Breuer Johannes , Weidenbach Michael , Berg Christoph , Kipfmueller Florian 
Published: March 2021

ZusammenfassungDie Mortalität von Patienten mit isoliert auftretenden angeborenen Zwerchfellhernien liegt in spezialisierten Zentren bei 20–40%. Wesentliche, das Outcome beeinflussende Faktoren, sind die bestehende Lungenhypoplasie, eine daraus resultierende pulmonale Hypertonie, sowie das Vorliegen weiterer Fehlbildungen. Begleitfehlbildungen wie angeborene Herzfehler treten bei ca. 18% aller Neonaten mit Zwerchfellhernie auf. Schwere angeborene Herzfehler wie das hypoplastische Linksherz Syndrom zeigen sich in ca. 8% der Fälle. In einer retrospektiven Analyse des Patientenkollektivs unserer Klinik zwischen 01/2012 und 12/2018 wurde das prä- und postnatale Management, sowie das Outcome von Neugeborenen mit der Kombination aus angeborenen Herzfehlern und Zwerchfellhernien untersucht. Im Studienzeitraum wurden in unserer Klinik 156 Neugeborene mit Zwerchfellhernie behandelt. Bei 10 Patienten (6,4%) lag zusätzlich ein schwerer, bei 11 Patienten (7,1%) ein moderater Herzfehler vor. 6/21 Patienten verstarben im Verlauf des Krankenhausaufenthaltes, davon 3 am ersten Lebenstag. Es zeigte sich eine deutlich geringere Mortalität bei Patienten mit Zwerchfellhernie und moderatem Herzfehler im Vergleich zu schwerem Herzfehler (9 vs. 50%). Besonders hoch lag die Mortalität bei Kindern mit einem univentrikulären Herzen. Trotz einer deutlich reduzierten Prognose bei der Kombination aus angeborenem Herzfehler und Zwerchfellhernie muss nicht generell mit einer infausten Prognose gerechnet werden. In spezialisierten Zentren kann ein kurativer Ansatz erfolgen.
Risk to Radiology Staff for Occupational COVID-19 Infection in a High-Risk and a Low-Risk Region in Germany: Lessons from the “First Wave”
Authors: Finkenzeller Thomas , Lenhart Stephan , Reinwald Mark , Lüth Stefan , Dendl Lena Marie , Paetzel Christian , Szczypien Natasza , Klawonn Frank , Von Meyer Alexander , Schreyer Andreas G. 
Published: March 2021

Purpose The recent COVID-19 pandemic has resulted in an increasing overload of the medical system. Healthcare workers (HCW) in radiology departments are exposed to a high infection risk similar to HCWs in the ICU or dedicated COVID wards. The goal of our paper is to evaluate the prevalence of IgG antibody against SARS-CoV-2 among radiology HCWs in two different hospitals and regions in Germany with a low and high COVID-19 prevalence and to compare it to the prevalence in other clinical personnel. Additionally, we assessed the number of radiological procedures performed in patients with a positive PCR test (C+) followed by a short review of the risk for nosocomial infections of radiology HCWs.
Materials and Methods During the first COVID-19 wave between March and July 2020, we evaluated a region with one of the highest COVID-19 rates (776–1570/100 000) in Germany (Hospital A). Additionally, we assessed Hospital B in a region with a low prevalence (65/100 000). We tested the serum prevalence of SARS-CoV-2 IgG antibodies among the whole staff with a subgroup analysis for radiology in both hospitals. We calculated the total number of different radiological procedures performed in C+ patients.
Results In Hospital A 594 PCR-proven C+ patients were treated resulting in 2723 radiological procedures. 24 % (n = 6) of the radiology technicians and 13.35 (n = 2) of radiologists had a positive IgG test. The rates were similar to positive rates in HCWs in COVID-19 wards and ICUs within the hospital. The most frequently performed procedures in C+ patients were chest X-rays (3.17/patient) and CT examinations (1.15/patient). In Hospital B 50 C+ patients were treated, resulting in 64 radiological procedures. None of the HCWs tested IgG positive. The most frequently performed examinations were also chest X-rays (1.04/patient) and CT (0.2/patient).
Conclusion HCWs in radiology have a high occupational infection risk similar to that of HCWs in ICUs and dedicated COVID wards.
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Palladium-Catalyzed sp3 C–H Benzoxylation of Alanine Derivatives Using Aldehydes under Ambient Conditions
Authors: Kanyiva Kyalo Stephen , Shibata Takanori , Tang King Hung Nigel , Wang Jiarui 
Published: March 2021

AbstractThe Pd(II)-catalyzed sp3 C–H bond benzoxylation of N-phthaloylalanine derivatives possessing an 8-aminoquinolyl group as a directing group with aldehydes under ambient conditions is reported. When a solution of an alanine derivative and an aldehyde in a toluene/water co-solvent was reacted in the presence of palladium catalyst and tert-butyl hydroperoxide at room temperature, a benzoxylated product was formed in up to 68% yield. The protecting group of the obtained benzoxylated product was smoothly removed to afford a free amide in high yield.
Synthesis of Chiral o-Aminobenzylamines by Stereoselective Addition of Grignard Reagents to N-[(o-Aminophenyl)methylene] sulfinamides
Authors: Zhou Wei , Zhong Xianqiang , Xiao Guorong 
Published: March 2021

AbstractChiral o-aminobenzylamines are synthons for many chiral ligands and catalysts that have been widely used in asymmetric synthesis. Here, we report a highly efficient and stereoselective addition of Grignard reagents to N-[(o-aminophenyl)methylene]sulfinamides to give a range of o-aminosulfinylimines in good yields with good to excellent diastereoselectivities.
Recent Advances in the Synthesis of 2,2′-Bipyridines and Their Derivatives
Authors: Rubtsov Aleksandr E. , Malkov Andrei V. 
Published: March 2021

AbstractThe sustained interest in the synthesis of new analogues of 2,2′-bipyridines is supported by the importance of compounds featuring bipyridine core in diverse areas of chemical, biomedical and materials research, which is relayed into the development of new approaches and the expansion of existing synthetic methods. This short review covers advances in the synthesis of 2,2′-bipyridines, including both the synthesis of compounds with a given substitution pattern and the development of new methods for assembling the bipyridine core. Special attention is directed toward the use of pyridine N-oxides and metal-free protocols to facilitate the formation of bipyridines. This short review focuses primarily on reports published in the last 5–6 years.1	Introduction2	Ullmann-Type Homocoupling Reactions3	Cross-Coupling Reactions in the Synthesis of Bipyridines4	Coupling Reactions Employing Pyridine N-Oxides5	Other Methods for the Synthesis of 2,2′-Bipyridines6	Conclusions and Outlook
“All in One or (W)hole in One Repair” for Adult Total Brachial Plexus Palsy
Authors: Purushothaman V. , Kumar K. Vinoth , Ambat Sabari Girish , Venkataswami R. 
Published: March 2021

Abstract
Background Total brachial plexus palsy (TBPP) accounts for nearly 50% of all brachial plexus injuries. Since achieving a good functional hand was almost impossible, the aim was settled to get a good shoulder and elbow function. It was Gu, who popularized the concept of utilizing contralateral C7 (CC7) with vascularized ulnar nerve graft (VUNG) to get some hand function. We have modified it to suit our patients by conducting it as a single-stage procedure, thereby trying to get a functional upper limb.
Methods From 2009 to 2014, we had 20 TBPP patients. We feel nerve reconstruction is always better than any other salvage procedure, including free muscle transfer. We modified Gu's concept and present our concept of total nerve reconstruction as “ALL IN ONE OR (W)HOLE IN ONE REPAIR.”
Results All patients able to move their reconstructed limbs independently or with the help of contralateral limbs. Three patients developed hook grip and one patient was able to incorporate limbs to do bimanual jobs. One important observation is that all the reconstructed limbs regain the bulk, and to a certain extent, the attitude and appearance looks normal, as patients no longer hide it or hang it in a sling.
Conclusion Adult brachial plexus injury itself is a devastating injury affecting young males. By doing this procedure, the affected limb is not dissociated from the rest of the body and rehabilitation can be aimed to get a supportive limb.
Venous Thromboembolism: Genetics and Thrombophilias
Authors: Gaddh Manila , Rosovsky Rachel P. 
Published: March 2021

AbstractVenous thromboembolism (VTE) is a major cause of morbidity and mortality throughout the world. Up to one half of patients who present with VTE will have an underlying thrombophilic defect. This knowledge has led to a widespread practice of testing for such defects in patients who develop VTE. However, identifying a hereditary thrombophilia by itself does not necessarily change outcomes or dictate therapy. Furthermore, family history of VTE by itself can increase an asymptomatic person's VTE risk several-fold, independent of detecting a known inherited thrombophilia. In this article, we will describe the current validated hereditary thrombophilias including their history, prevalence, and association with VTE. With a focus on evaluating both risks and benefits of testing, we will also explore the controversies of why, who, and when to test as well as discuss contemporary societal guidelines. Lastly, we will share how these tests have been integrated into clinical practice and how to best utilize them in the future.
Meniere’s Disease: New Frontiers in Management for Better Results
Authors: Velusamy Anand , Anand Aiswarya , Janarthanan Sridurga 
Published: March 2021

Abstract
Introduction Meniere's disease (MD) remains a difficult disease to diagnose, especially in the early stages when not all of the symptoms may be present. Sensorineural hearing loss, tinnitus, and recurrent vertigo constitute the hallmark symptoms of MD. Endolymphatic hydrops (EH) has been described as the responsible pathology in MD. Since that description, the medical and surgical treatment of MD have been directed at reducing the volume of endolymph. Unfortunately, these approaches have had equivocal success in the control of vertigo and recovery of hearing. So, a routine treatment directed at resolution of EH may not be suitable for all patients. Treatment has to be directed at the cause of EH whenever possible.
Objectives The aim of this study was to define new findings in clinical tests and modes of treatment in MD, to determine the outcome of vertigo and hearing in patients after treatment, and to describe treatment which will prevent long term deterioration of hearing.
Materials and Methods Forty-six new patients with a diagnosis of MD were treated with antiviral drugs or diuretics. Drugs were used based on nature of dehydration test. Hearing test including pure tone average (PTA) and speech discrimination (SD) was performed prior to treatment and at 1 to 2 months, 6 months, and 1 year after initiation of treatment. Effect on dizziness was recorded at each evaluation; hearing was judged to be improved, if PTA was lowered by at least 10 to 15 dB or an increase in SD > 20%.
Results The antiviral approach has virtually eliminated the use of various surgical methods used in the past. Dehydration test-based treatment protocol with diuretics and antivirals and antimigraine prophylaxis when needed has led to remission of disease in 93.5% of patients. With prompt treatment, inner ear damage can be prevented.
Conclusion Orally administered antiviral drugs should be considered in the treatment of MD. Migraine-associated MD patients need migraine prophylaxis and this will lead to improvement in Meniere’s symptoms also. If Intratympanic therapy is considered, then targeted low-dose delivery method of using Gelfoam instillation of gentamicin is preferable according to our study to prevent any significant hearing loss.
COVID-19 in an Asymptomatic Renal Transplant Recipient Employed in the Health Care Setting: A Case Report
Authors: Adnani Harsha , Khatri Akshay , Agrawal Nirav , Molmenti Ernesto , Bhaskaran Madhu 
Published: March 2021

AbstractDuring the ongoing pandemic, there have been varying presentations of coronavirus disease 2019 (COVID-19) infection, with the concern that patients who are immunosuppressed (due to underlying medical conditions and/or therapies) are at higher risk of severe disease. We report the case of an elderly renal transplant recipient working in a long-term health care facility who was being monitored by weekly surveillance testing and tested positive for COVID-19 by polymerase chain reaction (PCR) testing, despite having no clinical symptoms. He recovered with supportive care, despite being on multiple long-term immunosuppressant drugs and having multiple comorbidities. Additionally, it was found that he did not mount an antibody response, when he tested negative by serologic testing. Through this case, we wish to highlight the unique clinical scenario of asymptomatic patients who may have an underwhelming immune response to COVID-19, but may nevertheless be an important source of dissemination. We further discuss the probable mechanism of such asymptomatic presentations in immunosuppressed patients, while reinforcing the importance of self-isolation of COVID-19 patients (particularly in asymptomatic health care workers).
Absolute response of a Fuji BAS-TR imaging plate to low-energy protons (&lt;0.2 MeV) and carbon ions (&lt;1 MeV)
Authors: Kojima Sadaoki , Miyatake Tatsuhiko , Inoue Shunsuke , Dinh Thanh Hung , Hasegawa Noboru , Mori Michiaki , Sakaki Hironao , Nishiuchi Mamiko , Dover Nicholas P. , Yamamoto Yoichi , Sasaki Teru , Ito Fuyumi , Kondo Kotaro , Yamanaka Takashi , Hashida Masaki , Sakabe Shuji , Nishikino Masaharu , Kondo Kiminori 
Published: March 2021

This paper reports on the absolute response of a Fuji BAS-TR image plate to relatively low-energy protons (&lt;0.2 MeV) and carbon ions (&lt;1 MeV) accelerated by a 10-TW-class compact high-intensity laser system. A Thomson parabola spectrometer was used to discriminate between different ion species while dispersing the ions according to their kinetic energy. Ion parabolic traces were recorded using an image plate detector overlaid with a slotted CR-39 solid-state detector. The obtained response function for the protons was reasonably extrapolated from previously reported higher-ion-energy response functions. Conversely, the obtained response function for carbon ions was one order of magnitude higher than the value extrapolated from previously reported higher-ion-energy response functions. In a previous study, it was determined that if the stopping range of carbon ions is comparable to or smaller than the grain size of the phosphor, then some ions will provide all their energy to the binder resin rather than the phosphor. As a result, it is believed that the imaging plate response will be reduced. Our results show good agreement with the empirical formula of Lelasseux et al., which does not consider photo-stimulated luminescence (PSL) reduction due to the urethane resin. It was shown that the PSL reduction due to the deactivation of the urethane resin is smaller than that previously predicted.