bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Support and Diabetes Management Among Older American Indians
Authors: Goins R Turner , Grant Molly , Conte Kathleen , Lefler Lisa 
Published: December 2021

Abstract
We examined social support among older American Indians in relation to their diabetes management. In-depth interviews were conducted with 28 participants aged ≥ 60 years who were members of a federally-recognized tribe. We examined professionally transcribed audio recordings with a systematic text analysis approach. Main sources of social support were family/friends, clinicians/formal services, community/culture, and spiritual/God. Most of the support was instrumental in nature, including food shopping, meal preparation, and medication management. Social support had both positive and negative influences diabetes management while there were some participants who lacked support. The four main social support types were present, including instrumental, emotional, informational, appraisal support. Value orientations among American Indian families command lateral-group relational behavior rather than autonomy and independence with extended social systems fostering interdependence. A deeper understanding is needed of how social relationships can be better leveraged to aid in the effective diabetes management among older American Indians.
Changes in Modifiable Health Behaviors During the Pandemic and Effects on Mental Health: Evidence From England
Authors: Gessa Giorgio Di , Zaninotto Paola 
Published: December 2021

Abstract
COVID-19 mitigation efforts (including lockdowns and advice to stay at home as much as possible) are likely to have resulted in changes in health behaviours such as the amount of sleep, physical exercise, alcohol use, and eating. To date, little is known about how and to what extent these changes in health behaviours since the beginning of the pandemic are related to mental health. Using pre-pandemic data from Wave 9 (2018/19) and from two Covid-19 sub-studies (with data collection in June/July and November/December 2020) of the English Longitudinal Study of Ageing, we investigate how changes in health behaviour during the initial months of the pandemic are associated with subsequent mental health among older people. In our regression analyses, we considered depression and anxiety and controlled for pre-pandemic measures of mental health. Between March and June/July 2020, about a third of older people reported less physical activity; one in five less sleep; and one in ten eating less food and drinking more. Compared to respondents who did not change their behaviours, those who reported sleeping and eating both more and less, and who mentioned less physical activity were more likely to report depression and anxiety, even taking into account pre-pandemic mental health. An increase in drinking was also marginally associated with higher depression. Policymakers should encourage older people who have engaged in unhealthier behaviours to modify them to reduce the negative long-term effects on their mental health.
Impact of COVID-19 Mortality on U.S. Life Expectancy by Socioeconomic Rank of County of Residence
Authors: Dukhovnov Denys , Barbieri Magali 
Published: December 2021

Abstract
Mortality disparities due to COVID-19 pandemic in the US accentuated the gap in the targeted public health and education response among disadvantaged communities. We use county data from John Hopkins University of Medicine in conjunction with county socioeconomic decile rankings, and weekly national data from the Centers for Disease Control to uncover the impact of county-level socioeconomic deprivation on the spatio-temporal dynamic of COVID-19 mortality. We estimate that over the course of 2020, the pandemic reduced the life expectancy at birth by 1.33 years (95% CI 1.0-1.56), and by 0.84 years (95% CI 0.59-1.0) by age 85 across all county SES decile groups, relative to the previous year's projection. The highest losses occurred in counties at the ends of the deprivation spectrum, and least affecting those in its middle. Decomposition of the impact of the COVID-19 mortality by seasonal time periods of 2020 reveals that coastal urban and high-SES counties endured a heavy death toll in the initial stages of the pandemic, though managed to cut it by more than a half by the end of 2020. The least affluent, inland, and rural counties have experienced a dramatic and lasting increase in deaths toward the second half of the year. We find that preexisting socioeconomic disparities before COVID-19 remained in force during the pandemic, leaving populations at all ages residing in underserved communities at a greater risk. This both calls into question and further instructs the ongoing public health interventions enabling more effective and equitable infectious disease mitigation strategies.
Joseph T. Freeman and Excellence in Rehabilitation Award Lecture
Authors: Strotmeyer Elsa 
Published: December 2021

Abstract
The Joseph T. Freeman Award lecture will feature an address by the 2021 Freeman Award recipient Pamela Cacchione, PhD, CRNP, BC, FGSA, FAAN, of the University of Pennsylvania. The Joseph T. Freeman Award is a lectureship in geriatrics awarded to a prominent clinician in the field of aging, both in research and practice. The award was established in 1977 through a bequest from a patient's estate as a tribute to Dr. Joseph T. Freeman. The Excellence in Rehabilitation of Aging Persons Award lecture will feature an address by the 2021 Excellence in Rehabilitation Award recipient Gregory Hicks, MPT, PhD of the University of Delaware. The Excellence in Rehabilitation of Aging Persons Award is designed to acknowledge outstanding contributions in the field of the rehabilitation of aging individuals.
Joseph T. Freeman Award: Creating Synergy in Interdisciplinary Aging Research and Practice
Authors: Cacchione Pamela 
Published: December 2021

Abstract
Over 30 years of interdisciplinary practice stimulated many research questions. Early intervention research in sensory impairment, specifically vision and/or hearing impairment was heavily supported by interdisciplinary colleagues from Geriatric Medicine, Nursing, Occupational Therapy, Optometry and Audiology. Challenges and opportunities from this research created a growing interest in developing and designing technologies for older adults. Creating the need for partnerships with engineering. My expertise in aging and access to willing research participants made me an ideal research partner. Effectively expanding my focus beyond sensory impairment interventions to designing and testing robots with older adults. Currently we are testing low cost mobile robots in acute care and the community and are developing and testing a soft robot to assist persons out of a chair as well as turn and lift persons up in bed. The synergy of interdisciplinary practice and research is helping us innovate to improve the lives of older adults.
Challenges Reported by Certified Nursing Assistants During COVID-19: A Qualitative Study
Authors: Reinhardt Joann , Franzosa Emily , Mak Wingyun , Burack Orah 
Published: December 2021

Abstract
Certified nursing assistants (CNAs) who care for vulnerable nursing home residents faced unprecedented circumstances due to the COVID-19 pandemic. While staff and PPE shortages were ubiquitous and widely known, the focus of this qualitative work was to gain a broader understanding of the numerous challenges they faced. We conducted 10 remote focus groups with CNAs at 5 nursing homes (N=56) in downstate New York. Content analysis was conducted, and emerging themes identified. Results showed a myriad of emotional challenges including helplessness, fear and anxiety. Operational challenges focused on lack of COVID testing capacity, information, and consistent guidance and support, in addition to staff and equipment. Individual challenges included personal experience of COVID illness and that of colleagues, and balancing high concurrent demands of work and family. These results are discussed in the context of developing recommendations to promote future safety, skill refinement and enhanced resilience in the workforce moving forward.
Observing Personality in Everyday Life: How Personality Influences Daily Activities and Mood
Authors: Zhang Shiyang 
Published: December 2021

Abstract
Personality reflects the influence of older adults’ past experiences on their tendencies to engage in certain behaviors and generate emotions. An increasing number of studies have focused on the expression of personality in older adults’ everyday life. Specifically, personality features have been associated with daily activities, affect reactivity, and mood. This symposium draws on Ecological Momentary Assessments and longitudinal analysis to understand how personality is manifested in daily life, and how daily emotional experiences accumulate over time to influence physical health. Lee and colleagues examine how personality is associated with daily activities and find that extraversion is positively associated with activity diversity in two adult samples. Pasquini and colleagues consider the within-person fluctuations in personality traits and demonstrate the possibility of using daily behaviors and affect as markers of extraversion and neuroticism. Zhang and Fingerman assess how positive and negative moods concurrently change in reaction to daily social contacts and confirm that narcissism moderates such associations. Finally, this symposium also focuses on the cumulative effect of daily emotions on physical health. Leger and colleagues address the long-term association between personality (e.g., neuroticism, conscientiousness) and physical health and identify the mediating role of negative reactivity to daily stressors. Collectively, the presentations provide an in-depth analysis of personality’s impact on concrete daily behaviors and emotions, as well as their profound long-term effect on physical health. Our discussion outlines future research directions and highlights how inter-individual differences, simultaneous life events, and social interactions intertwine to influence individuals’ behaviors that occur in natural settings.
Race Differences in Trajectories of Hopelessness Among U.S. Older Adults: Do Social Conditions Matter?
Authors: Mitchell Uchechi , Graetz Elena , Wang Jing 
Published: December 2021

Abstract
Despite being a risk factor for cardiovascular disease, suicidal ideation, and mortality among U.S. older adults, research on hopelessness and how it changes over time are lacking. Although hopelessness generally increases with age, levels of hopelessness may be influenced by race/ethnicity and social or economic factors. This study uses longitudinal data from 8,359 individuals from the Health and Retirement Study to examine race differences in trajectories of hopelessness from 2006 to 2018. We used linear mixed models to estimate trajectories of hopelessness for blacks, whites and Hispanics age 51 and older. The model was fit with a natural spline cubic function to model changes in time trends of hopelessness and the interaction between time and race. Models controlled for demographic characteristics, socioeconomic status, health status, and psychosocial factors that influence hopelessness. We found that older Hispanics have the highest levels of hopelessness, followed by non-Hispanic blacks and non-Hispanic whites. Trajectories of hopelessness were non-linear and differed by race. For older whites, hopelessness increased from 2006-2010 and then decreased until 2018. For older blacks, it decreased the entire time period but did so at a decreasing rate; and, for older Hispanics, hopelessness decreased from 2006-2012 and then increased thereafter. Our study shows that hopelessness generally decreased over time among older adults between 2006 and 2018 in race-specific ways, despite generally increasing with age. These findings suggest that race, age and period effects differentially influence trajectories of hopelessness. Factors contributing to these differences may be related to concurrent social and economic conditions.
Privacy and Smart Speakers in Research With Older Adults
Authors: Quinn Kelly , Chin Jessie , Desai Smit , O'Connell Carrie , Marquez David , Muramatsu Naoko 
Published: December 2021

Abstract
Advances in artificial intelligence and computational linguistics have made smart speakers, such as Amazon Alexa^TM^ and Google Home^TM^, economical and widely available. For older adults particularly, devices with voice interfaces can help to overcome accessibility challenges that often accompany interaction with today’s technologies. However, voice-activation also requires devices to be in a continuous state of ambient listening, which can create a significant privacy risk for the user, one that is often amplified as smart speakers are placed in highly personal home spaces to facilitate their utility. Deployment of these devices in research settings poses additional risk, as traces of data filter through research teams, app developers, and third-party services that support research efforts. This presentation addresses the privacy aspects of deploying Google Home Mini^TM^ speakers in research that examined their feasibility for enhancing physical activity among sedentary older adults. Interviews with participants were conducted in two studies: the first included a demonstration of the device and physical activity program (n=15); and the second included in-home use of devices and a physical activity program (n=15). Content analysis of study documentation, field notes, and interviews revealed specific areas that require additional attention when utilizing smart speakers in research, including the capture of identifying information, protocols for data handling, and requirements for informed consent. These findings are discussed in context with extant literature on individual privacy concerns and behaviors related to smart household devices. Results from this study can inform future research efforts incorporating smart speakers, to mitigate potential risks of privacy violation.
John Henryism and Cognitive Function and Decline
Authors: McSorley V Eloesa , Howard Christopher , James Bryan , Shah Raj , Boyle Patricia , Barnes Lisa 
Published: December 2021

Abstract
Older Black adults in the US have higher prevalence and incidence of dementia and perform lower on cognitive tests than whites. Some of these differences have been attributed to facets of structural racism such as access to and quality of education and fewer socioeconomic resources. Here, we consider whether John Henryism (JH), a measure of self-perceived high-effort coping in the face of chronic environmental and psychosocial stressors, is associated with cognitive function and decline. JH has been associated with adverse cardiovascular health outcomes among African-Americans, especially those with fewer socioeconomic resources. Using data from MARS, we assessed whether JH, measured with an 8-item questionnaire (mean=16.9, sd=4.8, range: 4-27), was associated with level of cognitive function and rate of cognitive decline. We found one standard deviation increase in JH was associated with lower average cognitive function (□=-0.05, 95% CI: -0.09, -0.01). Higher JH was not associated with rate of cognitive decline.
Are Farmers Willing to Substitute Tobacco Cultivation? Evidence From Lichuan City, China
Authors: Wan Xinyu , Jin Jianjun , Ran Shenghong , Guan Tong , Qiu Xin 
Published: December 2021

Abstract

Introduction
Tobacco crop substitution is a critical element in implementing comprehensive tobacco control policies. Understanding tobacco farmers’ willingness or preferences is imperative to implement policies on tobacco crop substitution. This article assesses tobacco farmers’ individual willingness to substitute tobacco cultivation and investigates the factors that influence their willingness in Lichuan City, China.

Methods
We conducted a face-to-face survey with 280 tobacco farmers in Lichuan City of China to assess their willingness to substitute tobacco cultivation. The binary probit model was used to examine the factors influencing farmers’ willingness to substitute tobacco growing.

Results
The results show that fewer than one in five tobacco farmers are willing to substitute tobacco growing with other crops. The main reason for their unwillingness is that they thought the comparative income of growing tobacco was higher and more stable. The regression results show that tobacco farmers with higher education levels and more knowledge of tobacco crop substitution are more willing to take up tobacco crop substitution. Tobacco farmers’ household income decreased the likelihood of their willingness to replace tobacco cultivation. Farmers who perceived the economic benefits and health benefits of tobacco crop substitution are more likely to substitute tobacco cultivation with other crops.

Conclusions
Farmers’ willingness to substitute tobacco cultivation is low. Policy interventions are needed to increase farmers’ willingness to stop growing tobacco and to replace it with other alternative crops.

Implications
Few studies have investigated local farmers’ willingness to substitute tobacco cultivation in China. We found most tobacco farmers in the Lichuan City of China are unwilling to substitute tobacco growing with other crops. Farmers’ low support of tobacco crop substitution is associated with economic factors. Better education and more knowledge of tobacco crop substitution can increase farmers’ willingness to substitute tobacco cultivation.
Minimum Manufacturing Costs, National Prices, and Estimated Global Availability of New Repurposed Therapies for Coronavirus Disease 2019
Authors: Wang Junzheng , Levi Jacob , Ellis Leah , Hill Andrew 
Published: December 2021

Abstract

Background
Currently, only dexamethasone, tocilizumab, and sarilumab have conclusively been shown to reduce mortality of coronavirus disease 2019 (COVID-19). Safe and effective treatments will need to be both affordable and widely available globally to be used alongside vaccination programs. This analysis will estimate and compare potential generic minimum costs of a selection of approved COVID-19 drug candidates with available international list prices.

Methods
We searched for repurposed drugs that have been approved by at least one of the World Health Organization, US Food and Drug Administration, or the United Kingdom National Institute of Health and Care Excellence organizations or at least given emergency use authorization or recommended for off-label prescription. Drug prices were searched for dexamethasone, budesonide, baricitinib, tocilizumab, casirivimab, and imdevimab, and sarilumab, using active pharmaceutical ingredients (APIs) data extracted from global shipping records. This was compared with national pricing data from a range of low-, medium-, and high-income countries. Annual API export volumes from India were used to estimate the current availability of each drug.

Results
Repurposed therapies can be generically manufactured for some treatments at very low per-course costs, ranging from US $2.58 for intravenous (IV) dexamethasone (or US $0.19 orally) and US $4.34 for inhaled budesonide. No export price data were available for baricitinib, tocilizumab, casirivimab, and imdevimab, or sarilumab, but courses of these treatments have higher prices, ranging from US $6.67 for baricitinib to US $875.5 for sarilumab. When comparing international list prices, we found wide variations between countries.

Conclusions
Successful management of COVID-19 will require equitable access to treatment for all populations, not just those able to pay high prices. Dexamethasone and budesonide are widely available and affordable, whereas monoclonal antibodies and IV treatment courses are more expensive.
Epidemiology and Outcomes of Community-Acquired Escherichia coli Pneumonia
Authors: John Teny M , Deshpande Abhishek , Brizendine Kyle , Yu Pei-Chun , Rothberg Michael B 
Published: December 2021

Abstract

Background
E. coli is an under-recognized cause of bacterial community-acquired pneumonia (CAP). The objective of this study was to describe the epidemiology, risk factors, and outcomes of community-acquired Escherichia coli pneumonia in comparison with other gram-negative and pneumococcal pneumonias.

Methods
We conducted a large retrospective cohort study of adult patients admitted with pneumonia to 173 US hospitals included in the Premier Research database from July 2010 to June 2015. Patients were included if they had a principal diagnosis code for pneumonia or a principal diagnosis of respiratory failure or sepsis with a secondary diagnosis of pneumonia and had a positive blood or respiratory culture obtained on hospital day 1. The primary outcome was in-hospital case fatality. Secondary outcomes included intensive care unit admission, invasive mechanical ventilation, and use of vasopressors.

Results
Of 8680 patients with pneumonia and positive blood or respiratory cultures, 1029 (7.7%) had E. coli CAP. Patients with E. coli pneumonia were older and more likely to have a principal diagnosis of sepsis. Patients with E. coli pneumonia had significantly higher case fatality than patients with pneumococcal pneumonia (adjusted odds ratio, 1.55; 95% CI, 1.23–1.97), but it was not significantly different than other gram-negative pneumonias (adjusted odds ratio, 1.06; 95% CI, 0.85–1.32). Approximately 36% of the isolates were resistant to fluoroquinolones; 9.3% were resistant to ceftriaxone.

Conclusions
E. coli is an important cause of severe CAP; with mortality that was higher than pneumococcal pneumonia but similar to other gram-negative pneumonias. The rate of fluoroquinolone resistance was high, and empiric fluoroquinolones should be used with caution in these patients.
Hepatitis C Testing and Linkage to Care Among Adults on Probation in a Large US City
Authors: Kamis Kevin F , Wyles David L , Minturn Matthew S , Scott Tracy , McEwen Dean , Hurley Hermione , Prendergast Scott J , Rowan Sarah E 
Published: December 2021

Abstract

Background
Despite constituting the largest segment of the correctional population, individuals on probation remain largely unstudied with respect to hepatitis C virus (HCV) testing and linkage to care. We implemented an HCV testing and patient navigation program at an adult probation department.

Methods
Adults were tested at a local probation department with a rapid point-of-care HCV antibody (Ab) assay followed by a laboratory-based HCV ribonucleic acid (RNA) assay if anti-HCV positive. All individuals received counseling rooted in harm reduction principles. Individuals testing positive for HCV Ab were immediately linked to a patient navigator in person or via telephone. The patient navigator assisted patients through cure unless the patient was lost to follow-up. Study participation involved an optional survey and optional point-of-care human immunodeficiency virus test.

Results
Of 417 individuals tested, 13% were HCV Ab positive and 65% of those tested for HCV RNA (34 of 52) had detectable HCV RNA. Of the 14 individuals who linked to an HCV treatment provider, 4 completed treatment, as measured by pharmacy fill documentation in the electronic medical record, and 1 obtained sustained virologic response. One hundred ninety-three individuals tested for HIV; none tested positive.

Conclusions
The study cohort had a higher HCV seroprevalence than the general population (13% vs 2%), but linkage to care, completion of HCV treatment, and successful test-of-cure rates were all low. This study indicates that HCV disproportionately impacts adults on probation and prioritizing support for testing and linkage to care could improve health in this population. Colocalization of HCV treatment within probation programs would reduce the barrier of attending a new institution and could be highly impactful.