bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators to physical education, sport, and physical activity program participation among children and adolescents with psychiatric disorders: a systematic review
Authors: Hickingbotham Madison R , Wong Catherine J , Bowling April B 
Published: June 2021

AbstractChildren and adolescents with heterogeneous psychiatric disorders, of whom over 50% have a second psychiatric comorbidity, have low rates of physical activity and experience unique challenges to engaging in community-based exercise programming, school-based physical education programming, and targeted physical activity interventions. This contributes to elevated rates of gross and fine motor delays, lower mood and self-regulation, and increased risk of chronic diseases such as obesity and type 2 diabetes. Perform a systematic scoping review of the literature to assess known barriers to and facilitators of engaging in physical activity programming among children and adolescents with heterogeneous and/or comorbid psychiatric disorders, in order to improve engagement among this population in real world intervention settings. Systematic Boolean diagnostic and physical activity search terms were entered into PubMed, MEDLINE, PsycINFO and Web of Science for English-language studies published between 2005 and 2020, examining barriers and facilitators for common psychiatric diagnoses and general psychiatric population’s engagement in physical activity, physical education, sports, or exercise interventions. Two reviewers independently reviewed titles, abstracts and full articles to determine inclusion. A total of 5,198 articles were returned; 39 relating to children and adolescents were qualified for full-text review. After review, 24 studies were included addressing barriers and facilitators across multiple diagnoses; 7 studies were quantitative, 10 were qualitative, and 7 were mixed methods. Major barriers included low motivation, low self-efficacy, depleted parental reserve capacity, social isolation, lack of staff training, and safety concerns. Major facilitators included peer support/engagement, exergames, supportive parental behaviors, and inclusive/adaptive programming. Numerous barriers and facilitators to physical activity have been identified which should inform community, school, clinical, and research intervention program design. Further research is needed to develop effective strategies that address the challenges to inclusion that children and adolescents with heterogeneous and/or comorbid psychiatric disorders face.
III Middle English
Authors: Ash-Irisarri Kate , Atkinson Laurie , Black Daisy , Brazil Sarah , Calder Natalie , Finn Andrew , Greene Darragh , Grossman Joel , Lazikani Ayoush , Menmuir Rebecca , Pascual Rafael J , Sargan J D , Wolf Johannes 
Published: June 2021

AbstractThis chapter has thirteen sections: 1. Early Middle English; 2. Theory; 3. Manuscript and Technical Studies; 4. Religious Prose and Verse; 5. Secular Prose; 6. Sir Gawain and the Green Knight, Pearl, Patience and Cleanness; 7. Piers Plowman; 8. Gower; 9. Older Scots; 10. Drama; 11. Secular Verse; 12. Romance: Metrical, Alliterative, Prose. 13. Hoccleve and Lydgate. Section 1 is by Ayoush Lazikani; section 2 is by Andrew Finn; section 3 is by J.D. Sargan; section 4 is by Natalie Calder; section 5 is by Johannes Wolf; section 6 is by Rafael J. Pascual; section 7 is by Joel Grossman; section 8 is by Laurie Atkinson; section 9 is by Kate Ash-Irisarri; section 10 is by Daisy Black and Sarah Brazil; sections 11 and 12 are by Darragh Greene, with contributions by Johannes Woolf on Malory; 13 is by Rebecca Menmuir.
Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Quadrivalent Human Papillomavirus Vaccine in Boys and Girls 9–13 Years of Age in Malaysia
Authors: Hassan Jamiyah , Toh Teck-Hock , Sivapunniam Selva Kumar , Hasim Ruziaton , Ghazali Nor Faizah , Sulaiman Sofiah , Koh Mia Tuang , Meyer Stephanie , Toh Myew-Ling , Zocchetti Celine , Vigne Claire , Mascareñas Cesar 
Published: June 2021

Background:
Incorporating dengue vaccination within existing vaccination programs could help improve dengue vaccine coverage. We assessed the immunogenicity and safety of a quadrivalent human papillomavirus (HPV) vaccine administered concomitantly or sequentially with a tetravalent dengue vaccine (CYD-TDV) in healthy children 9–13 years of age in Malaysia.

Methods:
In this phase IIIb, open-label, multicenter study (NCT02993757), participants were randomized 1:1 to receive 3 CYD-TDV doses 6 months apart and 2 doses of quadrivalent HPV vaccine concomitantly with, or 1 month before (sequentially), the first 2 CYD-TDV doses. Only baseline dengue-seropositive participants received the 3 doses. Antibody levels were measured at baseline and 28 days after each injection using an enzyme-linked immunosorbent assay for HPV-6, -9, -16 and -18, and the 50% plaque reduction neutralization test for the 4 dengue serotypes; immunogenicity results are presented for baseline dengue-seropositive participants. Safety was assessed throughout the study for all participants.

Results:
At baseline, 197 of 528 (37.3%) randomized participants were dengue-seropositive [n = 109 (concomitant group) and n = 88 (sequential group)]. After the last HPV vaccine dose, antibody titers for HPV among baseline dengue-seropositive participants were similar between treatment groups, with between-group titer ratios close to 1 for HPV-6 and 0.8 for HPV-11, -16, and -18. After CYD-TDV dose 3, dengue antibody titers were similar between treatment groups for all serotypes [between-group ratios ranged from 0.783 (serotype 2) to 1.07 (serotype 4)]. No safety concerns were identified.

Conclusions:
The immunogenicity and safety profiles of CYD-TDV and quadrivalent HPV vaccines were unaffected when administered concomitantly or sequentially in dengue-seropositive children.
Pyloric gland adenoma with low-grade intraepithelial neoplasia
Authors: Li Hai-Long , Wang Yan , Ren Yu-Bo , Yang Xue-Song , Wang Li , Zhang Lei , Lin Xiang-Chun 
Published: June 2021

Abstract

Rationale:
Pyloric gland adenoma (PGA) is often associated with pyloric gland metaplasia. It has high malignant potential but a low clinical diagnosis rate. Therefore, we reported a case of PGA and reviewed the literature to summarize the clinicopathological features of pyloric adenoma.

Patient concerns:
A 62-year-old female underwent gastroscopy due to intermittent acid regurgitation and heartburn, which revealed a 4×6 mm flat, elevated lesion in the greater curvature of the upper gastric body, with depression in the central region and blood scab attachment.

Diagnosis and intervention:
Biopsy revealed gastric adenoma with low-grade intraepithelial neoplasia. The patient was treated with ESD, and pathology showed gastric pyloric gland adenoma with low-grade dysplasia. The cells were positive for MUC6 and MUC5AC immunohistochemically.

Outcomes:
The patient received proton pump inhibitors and gastric mucosal protective agents for one month after ESD. She occasionally presented acid regurgitation and heartburn, with no abdominal pain, abdominal distension, melena, or hematochezia. Follow-up gastroscopy will be reexamined 1 year later.

Lessons:
PGA has nonspecific performance under endoscopy, and its diagnosis mainly depends on pathology. Clinicians need to increase their ability to recognize such lesions and treat them in time to improve the prognosis.
Evaluation of efficiency and safety of combined montelukast sodium and budesonide in children with cough variant asthma
Authors: Tang Qiongyao , Lei Huizhen , You Jinbing , Wang Jiangjiang , Cao Junyi 
Published: June 2021

Abstract

Background:
Cough variant asthma (CVA) is classified as a distinct form of asthma. As the primary or only symptom, cough is the leading cause for the most prevalent chronic cough among kids. The American College of Clinical Pharmacy, British Thoracic Society, and Chinese guidelines established for diagnosing and treating chronic cough in kids recommend inhaled corticosteroids, combined with leukotriene receptor antagonists when necessary.

Methods:
We will conduct a comprehensive search in major databases using keywords to find studies related to the analysis of montelukast sodium and budesonide for treating CVA in kids. Two reviewers will independently assess the quality of the selected research articles and perform data extraction. Next, we will use the RevMan software (version: 5.3) to conduct the statistical analysis of the present study.

Results:
This study will assess the efficacy and safeness of using montelukast sodium and budesonide to treat kids with CVA by pooling the results of individual studies.

Conclusion:
Our findings will provide vigorous evidence to judge whether montelukast sodium and budesonide therapy is an efficient form of therapy for CVA patients.

Ethics and dissemination:
Ethics approval is not needed for the present meta-analysis.

OSF registration number:
May 17, 2021.osf.io/cuvjz (https://osf.io/cuvjz/).
Exercise and Stress in At-Risk Women during Pregnancy and Postpartum
Authors: Guo Yuqing , Kehoe Priscilla , Pimentel Pamela , Rousseau Julie , Axelin Anna , Rahmani Amir M. , Dutt Nikil 
Published: June 2021

Abstract

Purpose:
We aimed to understand the relationship between exercise and stress among socioeconomically at-risk women who participated in a home visitation service during pregnancy and postpartum.

Methods:
A mixed-methods design was used to support and supplement quantitative data using qualitative data. Convenience sampling was used to collect data from at-risk women via questionnaires and follow-up interviews. The Perceived Stress Scale was used to assess stress. Frequency and duration of exercise were assessed based on the American College of Obstetricians and Gynecologists exercise guidelines. Regression analyses examined the association between stress and exercise controlling for covariates. Content analysis was used to understand women's stress management experiences.

Results:

N = 114 women completed the questionnaire and a subgroup of 11 received follow-up interviews. Greater frequency of exercise was significantly associated with lower levels of stress. Approximately one-third of women reported experiencing significant stress. Talking to their husband or partner was the most used and exercise was the least used coping strategy. Many women recognized the importance of managing stress and benefits of exercise, but were hindered by barriers such as feeling tired, preventing them from exercising.

Clinical Implications:
A personalized and safe exercise program has the potential to be a low-cost stress management strategy for women during pregnancy and postpartum.
Maternal Self-Confidence and Breastfeeding after Participating in a Program about Infant Prone Positioning
Authors: Jesberger Colleen , Chertok Ilana Azulay , Wessells Allyson , Schaumleffel Carol 
Published: June 2021

Abstract

Purpose:
Maternal self-confidence facilitates infant growth and new mother role development. Infant ability to breastfeed and maternal breastfeeding self-confidence are imperative to helping mothers meet their breastfeeding goals. Consistent opportunity for infant movement in the prone position has been shown to improve breastfeeding ability; however, families report a lack of knowledge of how to safely support this activity. Perceptions of maternal self-confidence, infant development, and breastfeeding success upon completion of an infant prone positioning program with focus on posture, movement, and connection were studied.

Study Design and Methods:
Qualitative interviews were conducted among breastfeeding mothers in three states to explore maternal perceptions of learning about infant prone positioning.

Results:
Thirty-five mothers who completed an infant prone positioning program shared their perceptions of infant interaction, prone play and positioning, and breastfeeding self-confidence. Four primary themes were identified from the analysis: maternal knowledge and self-confidence; strategies and practices learned; breastfeeding benefits of infant prone positioning; and motivation for program participation.

Clinical Implications:
Our findings support consideration of teaching new mothers about prone positioning to enhance self-confidence in mothering, breastfeeding skills, infant development, and maternal–infant dyad bonding.
Incidence, Risk Factors, and Treatment of Proximally Migrated Pancreatic Stents
Authors: Gokbulut Volkan , Kaplan Mustafa , Odemis Bulent , Disibeyaz Selcuk , Parlak Erkan , Kilic Zeki M.Y. , Oztas Erkin 
Published: June 2021

Aim:
The aim of this study was to investigate the incidence, risk factors, and treatment strategies of proximally migrated pancreatic stents.

Materials and Methods:
The data of 626 sessions of 421 patients with pancreatic duct stenting were retrospectively analyzed between 2010 and 2018, and patients with proximally migrated stents were included in the study.

Results:
Of 626 stents examined, 77 migrated proximally (12%). The migration rate (MR) was 16%, 2%, and 7%, respectively, in patients treated with chronic pancreatitis, malignancy, and pancreatic leakage indication. The MR was 14% in procedures with pancreatic duct stenosis, 21% in procedures with pancreatic sphincterotomy, and 27% in procedures performed from minor papillae. The MR of the 5, 7, and 10 Fr stents was 4%, 17%, and 10%, respectively. Of the 77 migrated stents, 64 were successfully removed (83%). This success rate (SR) was 84% in procedures with chronic pancreatitis indication, 83% in procedures with pancreatic duct stenosis, 79% in procedures with sphincterotomy, and 75% in procedures performed from minor papillae. The SR of the 5, 7, and 10 Fr stents was 100%, 79%, and 92%, respectively. It was also determined that 33 stents were fractured and migrated (43%). The SR of the fractured stents was 76%. Moreover, of the stents that were successfully removed, 35 were removed with forceps (55%) and 15 (23%) were removed with a balloon. Furthermore, in 47 cases, the stent was removed in the first session (73%). Acute pancreatitis occurred in 5 patients (8%) and perforation occurred in 1 patient (2%).

Conclusion:
In this study, it was shown that proximal migration of pancreatic stents is frequent and most of these stents can be removed successfully.
Predicting thermal injury patient outcomes in a Tertiary-Care Burn Centre, Pakistan
Authors: Bajwa Mohammad Suleman , Sohail Muhammad , Ali Hamza , Nazir Umer , Bashir Muhammad Mustehsan 
Published: June 2021

AbstractObjectivesTo explore candidate parameters for their ability to predict survival and length of hospital stay (LOS) in thermal burns patients, to prepare multivariate predictive models for these two outcomes, and to compare performance of native models to other models.MethodsA retrospective cohort study was undertaken based on record review. Data was extracted from files of patients admitted to a tertiary-care burn centre in Lahore, Pakistan from January 1, 2020 to October 31, 2020. Univariate preselection was used to prepare multivariate logistic regression models for each outcome of interest (survival and LOS). Multivariate models were tested and compared to other models.ResultsIncreasing TBSA of burn was positively associated with reduced survival and prolonged length of stay. Advancing age and full-thickness burns independently predicted decreased survival. Burn etiology showed prognostic value: petrol-flame burns predicted decreased survival and prolonged LOS; scald was associated with improved survival-odds and shorter LOS. The Survival-model consisted of (1) Baux score, (2) TBSA>40% and (3) serum albumin <3.5g/dl (AUC=0.968, Nagelkerke R2=0.797). The LOS-model consisted of (1) TBSA2 and (2) serum albumin concentration (AUC= 0.832, Nagelkerke R2 =0.408). In tests of discrimination and calibration, native models prepared for survival and LOS outcomes outperformed other models applicable to our dataset.ConclusionData from a South Asian burn center has been used to explore factors influencing prognosis for their utility in predictive models for survival and the duration of hospital stay. The significant prognostic roles of TBSA, age, inhalational injury, burn-depth, etiology of burn, anatomic site of burn, hypoalbuminemia and other biochemical parameters were observed. These tools hold significance in guiding healthcare policy and in communications with patients and their families.
Delay of molecular SARS-CoV-2 testing and turnaround time in Mexico and Colombia
Authors: Núñez Isaac , Belaunzarán-Zamudio Pablo F. , Caro-Vega Yanink 
Published: June 2021

AbstractObjectiveTo quantify the delay in SARS-CoV-2 real time polymerase chain reaction (RT-PCR) testing and test result reporting in Mexico and Colombia, and to assess the relation between margination status and these delays.MethodsWe quantified time in days from symptom onset until testing (latency one) and delay in test results report (latency two) using freely available country-wide open data from Mexico and Colombia. Directed acyclic graphs were built to determine which associations were appropriate to assess. Stratification by margination status, state and hospitalization status was used to determine corresponding associations.ResultsIn almost all the study period latency two was longer than latency one. Median latency one was 3 (IQR 0-6) days and latency two 7 (IQR 4-11) days in Colombia, while in Mexico they were 3 (IQR 1-5) days and 4 (IQR 3-6) days. In Colombia, worse margination status prolonged latency two. In Mexico, a lower number and percentage of point-of-care (POC) tests in areas with worse margination.ConclusionPOC tests must be used as a widespread means to reduce latency two, and until then should be prioritized in areas with longer latency two. An unequal distribution of this resource should be avoided.
T-cell mediated immunity after AZD1222 vaccination: A polyfunctional spike-specific Th1 response with a diverse TCR repertoire
Authors: Swanson Phillip A. , Padilla Marcelino , Hoyland Wesley , McGlinchey Kelly , Fields Paul A. , Bibi Sagida , Faust Saul N. , McDermott Adrian B. , Lambe Teresa , Pollard Andrew J. , Durham Nicholas M. , Kelly Elizabeth J. 
Published: June 2021

AbstractAZD1222 (ChAdOx1 nCoV-19), a replication-deficient simian adenovirus-vectored vaccine, has demonstrated safety, efficacy, and immunogenicity against coronavirus disease 2019 (COVID-19) in clinical trials and real-world studies. We characterized CD4+ and CD8+ T-cell responses induced by AZD1222 vaccination in peripheral blood mononuclear cells (PBMCs) from 280 unique vaccine recipients aged 18–85 years who enrolled in the phase 2/3 COV002 trial. Total spike-specific CD4+ T cell helper type 1 (Th1) and CD8+ T-cell responses were significantly increased in AZD1222-vaccinated adults of all ages following two doses of AZD1222. CD4+ Th2 responses following AZD1222 vaccination were not detected. Furthermore, AZD1222-specific Th1 and CD8+ T cells both displayed a high degree of polyfunctionality in all adult age groups. T-cell receptor (TCR) β sequences from vaccinated participants mapped against TCR sequences known to react to SARS-CoV-2 revealed substantial breadth and depth across the SARS-CoV-2 spike protein for the AZD1222-induced CD4+ and CD8+ T-cell responses. Overall, AZD1222 vaccination induced a robust, polyfunctional Th1-dominated T-cell response, with broad CD4+ and CD8+ T-cell coverage across the SARS-CoV-2 spike protein.One Sentence SummaryPolyfunctional CD4+ and CD8+ T-cell responses are elicited against the SARS-CoV-2 spike protein following vaccination with AZD1222
Assessing the Impact of Mental Health Difficulties on Young People’s Daily Lives: Protocol for a Scoping Umbrella Review of Measurement Instruments
Authors: Krause Karolin Rose , Chung Sophie , Rodak Terri , Cleverley Kristin , Butcher Nancy J , Szatmari Peter 
Published: June 2021

AbstractIntroductionAn important consideration for determining the severity of mental health symptoms is their impact on youth’s daily lives. Those wishing to assess life impact face several challenges: First, various measurement instruments are available, including of global functioning, health-related quality of life (HRQoL), and well-being. Existing reviews have tended to focus on one of these domains; consequently, a comprehensive overview is lacking. Second, the extent to which such instruments truly capture distinct concepts is unclear. Third, many available scales conflate symptoms and their impact, thus undermining much needed analyses of associations between the two.Methods and analysisA scoping umbrella review will examine existing reviews of life impact measures for use with 6-24-year-olds in the context of mental health and well-being research. We will systematically search five bibliographic databases (MEDLINE, Embase, APA PsycINFO, CINAHL, Web of Science), and conduct systematic record screening, data extraction and charting based on methodological guidance by the Joanna Briggs Institute (JBI). Data synthesis will involve the tabulation of scale characteristics, feasibility, and measurement properties, and the use of summary statistics to synthesize how these instruments operationalize life impact.Ethics and disseminationThis study will provide a comprehensive road map for researchers and clinicians seeking to assess life impact in youth mental health, providing guidance in navigating available measurement options. We will seek to publish the findings in a leading peer-reviewed journal in the field. Formal research ethics approval will not be required.Registration detailsThis protocol was registered prospectively with the Open Science Framework (osf.io/jfqdv).Strengths and Limitations of this StudyUmbrella review methodology will enable a higher-level synthesis of existing review efforts, thus generating a comprehensive map of available measurement instruments and research findings about their properties.Our methodological approach is based on the JBI guidelines for scoping reviews, umbrella reviews, and psychometric reviews.This review is based on a rigorous systematic search developed and executed by a health science librarian.We will only include studies published in the English language since 1990.As this is a scoping umbrella review designed to map available measurement instruments, the quality and risk of bias of included review articles will not be systematically assessed.