bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing parents’ awareness about children’s “first thousand days of life”: a descriptive and analytical study
Authors: Bagheri Fatemeh , Nakhaee Nouzar , Jahani Yones , Khajouei Reza 
Published: August 2021

Abstract
Background
Many adulthood illnesses are rooted in childhood, especially in the “first thousand days of life”. Despite parents’ role in children’s development, no study has examined parental awareness concerning this period. This study aimed to examine the awareness of parents concerning the “first thousand days of life” and the relationship between parents’ demographics and their awareness.

Methods
This study was conducted on 135 parents in Kerman, Iran, using a valid and reliable questionnaire developed by researchers based on the opinion of experts and relevant references. The relationship between participants’ demographics and their awareness was examined by multiple regression. The relationship between homogeneity of couples’ education degree and awareness was analyzed using ANOVA. Chi-square was used to examine the relationship between information sources and parents’ familiarity and to compare parents’ preferred sources.

Results
The average parental awareness was 41.96 ± 11.90. Eighty-three percent of the parents have not heard about the “first thousand days of life”. The source of information for 57% of the parents was friends and relatives (p < 0.0001). Overall, 87% of the parents desired to know about this period, and 47% liked using mobile applications for information (p < 0.0001).

Conclusions
Parents’ awareness about the “first thousand days of life” is lower than the average. Since the source of information concerning this period for most parents is friends and relatives and most parents are very interested in obtaining information, it is recommended that policy-makers use the capacity of other sources to increase parents’ awareness. Given the greater tendency of parents to obtain information through mobile applications, we suggest investing more in this source.
Technologies for recovery and reuse of plant nutrients from human excreta and domestic wastewater: a protocol for a systematic map and living evidence platform
Authors: Macura Biljana , Thomas James , Metson Geneviève S. , McConville Jennifer R. , Johannesdottir Solveig L. , Seddon Dan , Harder Robin 
Published: August 2021

Abstract
Background
Research and development on the recovery and reuse of nutrients found in human excreta and domestic wastewater has intensified over the past years, continuously producing new knowledge and technologies. However, research impact and knowledge transfer are limited. In particular, uptake and upscaling of new and innovative solutions in practice remain a key challenge. Achieving a more circular use of nutrients thus goes beyond technological innovation and will benefit from a synthesis of existing research being readily available to various stakeholders in the field. The aim of the systematic map and online evidence platform described in this protocol is threefold. First, to collate and summarise scientific research on technologies that facilitate the recovery and reuse of plant nutrients and organic matter found in human excreta and domestic and municipal wastewater. Second, to present this evidence in a way that can be easily navigated by stakeholders. Third, to report on new relevant research evidence to stakeholders as it becomes available.

Methods
Firstly, we will produce a baseline systematic map, which will consist of an extension of two previous related syntheses. In a next stage, with help of machine learning and other automation technologies, the baseline systematic map will be transformed into ‘living mode’ that allows for a continually updated evidence platform. The baseline systematic map searches will be performed in 4 bibliographic sources and Google Scholar. All searches will be performed in English. Coding and meta-data extraction will include bibliographic information, locations as well as the recovery and reuse pathways. The living mode will mostly rely on automation technologies in EPPI-Reviewer and the Microsoft Academic database. The new records will be automatically identified and ranked in terms of eligibility. Records above a certain ‘cut-off’ threshold will be manually screened for eligibility. The threshold will be devised based on the empirically informed machine learning model. The evidence from the baseline systematic map and living mode will be embedded in an online evidence platform that in an interactive manner allows stakeholders to visualise and explore the systematic map findings, including knowledge gaps and clusters.
The curative effect analysis of peripherally inserted central venous catheter catheterization for tumor patients under the guidance of new medical guide wire
Authors: Xiao Weizhu 
Published: August 2021

Abstract
Objective
To report a method of PICC catheterization with the aid of a new medical guide wire, and to discuss the curative effect.

Methods
Five hundred and thirteen patients who visited our hospital from January 2013 to December 2019 for PICC catheterization were selected as study subjects. Random number method was used to group patients. General information was recorded for both groups. Patients in the observation group received catheterization with the aid of a new medical guide wire. The control group received catheterization via conventional guide wire. The success rate of the first catheterization, the success rate of the catheterization, the timing of the catheterization, the complications and the position of the catheter end were compared between the two groups.

Results
There was no significant difference in general information between the two groups. After analyzing the puncture situation of the two groups, it was found that the average catheterization time of the observation group was shorter than that of the control group, and the difference was statistically significant. Patients in the observation group had higher success rate of one-time catheterization and catheterization success rate, and the difference was statistically significant. The incidences of occult thrombosis, phlebitis and catheter blockage in the observation group were lower than those in the control group, and the difference was statistically significant. The incidence of dominant thrombosis and bleeding at puncture point in the observation group was also lower than that in the control group, but the difference was not statistically significant.

Conclusion
The new type of medical guide wire component is effective for PICC catheterization and worthy of further promotion.
Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico
Authors: Ortega Pilar E. Núñez , Meneses María E. , Delgado-Enciso Iván , Irecta-Nájera César Antonio , Castro-Quezada Itandehui , Solís-Hernández Roberto , Flores-Guillén Elena , García-Miranda Rosario , Valladares-Salgado Adán , Locia-Morales Daniel , Ochoa-Díaz-López Héctor 
Published: August 2021

Abstract
Background
Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas.

Methods
In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components.

Results
The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3–5.3; p = 0.007).

Conclusions
Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.
The influence of changing reward of electronic consumer goods on burglary and theft offences in Western market-based countries in the years prior to and during the crime drop
Authors: Quinn Liam , Clare Joseph 
Published: August 2021

AbstractIt is widely recognised that burglary and theft offence trends have broadly moved in parallel in ‘Western’ market-based countries since the 1950s. Most researchers have focussed on the trend from the early 1990s onwards, when burglary and theft offence rates plummeted. One major proposed explanation for this trend, relates to improved security. This paper draws on the longitudinal variations in reward of electronic consumer goods to propose a complementary account. This argument is supported by criminological theory, empirical evidence, and historical trends of specific property crime offences. The paper concludes by explaining that reward and security operate in partnership to influence the opportunity for crime, which provides an optimal account for burglary and theft offence trends over the last 40 years.
Longitudinal study on the effects of growth-promoting and therapeutic antibiotics on the dynamics of chicken cloacal and litter microbiomes and resistomes
Authors: Gupta Chhedi Lal , Blum Shlomo E. , Kattusamy Karuppasamy , Daniel Tali , Druyan Shelly , Shapira Roni , Krifucks Oleg , Zhu Yong-Guan , Zhou Xin-Yuan , Su Jian-Qiang , Cytryn Eddie 
Published: August 2021

AbstractBackgroundTherapeutic and growth-promoting antibiotics are frequently used in broiler production. Indirect evidence indicates that these practices are linked to the proliferation of antimicrobial resistance (AMR), the spread of antibiotic-resistant bacteria from food animals to humans, and the environment, but there is a lack of comprehensive experimental data supporting this. We investigated the effects of growth promotor (bacitracin) and therapeutic (enrofloxacin) antibiotic administration on AMR in broilers for the duration of a production cycle, using a holistic approach that integrated both culture-dependent and culture-independent methods. We specifically focused on pathogen-harboring families (Enterobacteriaceae,Enterococcaceae, andStaphylococcaceae).ResultsAntibiotic-resistant bacteria and antibiotic resistance genes were ubiquitous in chicken cloaca and litter regardless of antibiotic administration. Environment (cloaca vs. litter) and growth stage were the primary drivers of variation in the microbiomes and resistomes, with increased bacterial diversity and a general decrease in abundance of the pathogen-harboring families with age. Bacitracin-fed groups had higher levels of bacitracin resistance genes and of vancomycin-resistantEnterococcaceae(totalEnterococcaceaecounts were not higher). Although metagenomic analyses classified 28–76% of theEnterococcaceaeas the commensal human pathogensE. faecalisandE. faecium, culture-based analysis suggested that approximately 98% of the vancomycin-resistantEnterococcaceaewere avian and not human-associated, suggesting differences in the taxonomic profiles of the resistant and non-resistant strains. Enrofloxacin treatments had varying effects, but generally facilitated increased relative abundance of multidrug-resistantEnterobacteriaceaestrains, which were primarilyE. coli. Metagenomic approaches revealed a diverse array ofStaphylococcusspp., but the opportunistic pathogenS. aureusand methicillin resistance genes were not detected in culture-based or metagenomic analyses.Camphylobacteriaceaewere significantly more abundant in the cloacal samples, especially in enrofloxacin-treated chickens, where a metagenome-assembledC. jejunigenome harboring fluoroquinolone and β-lactam resistance genes was identified.ConclusionsWithin a “farm-to-fork, one health” perspective, considering the evidence that bacitracin and enrofloxacin used in poultry production can select for resistance, we recommend their use be regulated. Furthermore, we suggest routine surveillance of ESBLE. coli, vancomycin-resistantE. faecalisandE. faecium, and fluoroquinolone-resistantC. jejunistrains considering their pathogenic nature and capacity to disseminate AMR to the environment.
Evaluation of low-pass genome sequencing in polygenic risk score calculation for Parkinson’s disease
Authors: Kim Sungjae , Shin Jong-Yeon , Kwon Nak-Jung , Kim Chang-Uk , Kim Changhoon , Lee Chong Sik , Seo Jeong-Sun 
Published: August 2021

Abstract
Background
Low-pass sequencing (LPS) has been extensively investigated for applicability to various genetic studies due to its advantages over genotype array data including cost-effectiveness. Predicting the risk of complex diseases such as Parkinson’s disease (PD) using polygenic risk score (PRS) based on the genetic variations has shown decent prediction accuracy. Although ultra-LPS has been shown to be effective in PRS calculation, array data has been favored to the majority of PRS analysis, especially for PD.

Results
Using eight high-coverage WGS, we assessed imputation approaches for downsampled LPS data ranging from 0.5 × to 7.0 × . We demonstrated that uncertain genotype calls of LPS diminished imputation accuracy, and an imputation approach using genotype likelihoods was plausible for LPS. Additionally, comparing imputation accuracies between LPS and simulated array illustrated that LPS had higher accuracies particularly at rare frequencies. To evaluate ultra-low coverage data in PRS calculation for PD, we prepared low-coverage WGS and genotype array of 87 PD cases and 101 controls. Genotype imputation of array and downsampled LPS were conducted using a population-specific reference panel, and we calculated risk scores based on the PD-associated SNPs from an East Asian meta-GWAS. The PRS models discriminated cases and controls as previously reported when both LPS and genotype array were used. Also strong correlations in PRS models for PD between LPS and genotype array were discovered.

Conclusions
Overall, this study highlights the potentials of LPS under 1.0 × followed by genotype imputation in PRS calculation and suggests LPS as attractive alternatives to genotype array in the area of precision medicine for PD.
Deubiquitinases in hematological malignancies
Authors: Lei Hu , Wang Jiaqi , Hu Jiacheng , Zhu Qian , Wu Yingli 
Published: August 2021

AbstractDeubiquitinases (DUBs) are enzymes that control the stability, interactions or localization of most cellular proteins by removing their ubiquitin modification. In recent years, some DUBs, such as USP7, USP9X and USP10, have been identified as promising therapeutic targets in hematological malignancies. Importantly, some potent inhibitors targeting the oncogenic DUBs have been developed, showing promising inhibitory efficacy in preclinical models, and some have even undergone clinical trials. Different DUBs perform distinct function in diverse hematological malignancies, such as oncogenic, tumor suppressor or context-dependent effects. Therefore, exploring the biological roles of DUBs and their downstream effectors will provide new insights and therapeutic targets for the occurrence and development of hematological malignancies. We summarize the DUBs involved in different categories of hematological malignancies including leukemia, multiple myeloma and lymphoma. We also present the recent development of DUB inhibitors and their applications in hematological malignancies. Together, we demonstrate DUBs as potential therapeutic drug targets in hematological malignancies.
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies
Authors: Hass Ethan W. , Sorrentino Zachary A. , Xia Yuxing , Lloyd Grace M. , Trojanowski John Q. , Prokop Stefan , Giasson Benoit I. 
Published: August 2021

AbstractSynucleinopathies, including Parkinson’s disease (PD), Lewy body dementia (LBD), Alzheimer’s disease with amygdala restricted Lewy bodies (AD/ALB), and multiple system atrophy (MSA) comprise a spectrum of neurodegenerative disorders characterized by the presence of distinct pathological α-synuclein (αSyn) inclusions. Experimental and pathological studies support the notion that αSyn aggregates contribute to cellular demise and dysfunction with disease progression associated with a prion-like spread of αSyn aggregates via conformational templating. The initiating event(s) and factors that contribute to diverse forms of synucleinopathies remain poorly understood. A major post-translational modification of αSyn associated with pathological inclusions is a diverse array of specific truncations within the carboxy terminal region. While these modifications have been shown experimentally to induce and promote αSyn aggregation, little is known about their disease-, region- and cell type specific distribution. To this end, we generated a series of monoclonal antibodies specific to neo-epitopes in αSyn truncated after residues 103, 115, 119, 122, 125, and 129. Immunocytochemical investigations using these new tools revealed striking differences in the αSyn truncation pattern between different synucleinopathies, brain regions and specific cellular populations. In LBD, neuronal inclusions in the substantia nigra and amygdala were positive for αSyn cleaved after residues 103, 119, 122, and 125, but not 115. In contrast, in the same patients' brain αSyn cleaved at residue 115, as well as 103, 119 and 122 were abundant in the dorsal motor nucleus of the vagus. In patients with AD/ALB, these modifications were only weakly or not detected in amygdala αSyn inclusions. αSyn truncated at residues 103, 115, 119, and 125 was readily present in MSA glial cytoplasmic inclusions, but 122 cleaved αSyn was only weakly or not present. Conversely, MSA neuronal pathology in the pontine nuclei was strongly reactive to the αSyn x-122 neo-epitope but did not display any reactivity for αSyn 103 cleavage. These studies demonstrate significant disease-, region- and cell type specific differences in carboxy terminal αSyn processing associated with pathological inclusions that likely contributes to their distinct strain-like prion properties and promotes the diversity displayed in the degrees of these insidious diseases.
Lithosphere–asthenosphere boundary beneath the Sea of Japan from transdimensional inversion of S-receiver functions
Authors: Akuhara Takeshi , Nakahigashi Kazuo , Shinohara Masanao , Yamada Tomoaki , Shiobara Hajime , Yamashita Yusuke , Mochizuki Kimihiro , Uehira Kenji 
Published: August 2021

AbstractThe evolution history of the Sea of Japan back-arc basin remains under debate, involving the opening of sub-basins such as the Japan and Yamato Basins. Detailed knowledge of the lithospheric structure will provide the key to understanding tectonic history. This study identifies the lithosphere–asthenosphere boundary (LAB) beneath the Sea of Japan back-arc basin using S-receiver functions (S-RFs). The study area, including the Japan and Yamato Basins, has been instrumented with broadband ocean-bottom seismometers (OBSs). S-RFs from these OBSs show negative Sp phases preceding the direct S arrivals, suggesting the LAB. The S-RFs also show abnormally reduced amplitudes. For further qualitative interpretation of these findings, we conduct transdimensional Bayesian inversion for S-wave velocity models. This less-subjective Bayesian approach clarifies that the low-velocity seafloor sediments and damped deconvolution contribute to the amplitude reduction, illuminating the necessity of such considerations for similar receiver function works. Inverted velocity structures show a sharp velocity decrease at the mantle depths, which we consider the LAB. The obtained LAB depths vary among sites: ~ 45 km beneath the Japan and Yamato Basins and ~ 70 km beneath the Yamato Rise, a bathymetric high between the two basins. The thick lithosphere beneath the Yamato Rise most likely reflects its continental origin. However, the thickness is still thin compared to that of eastern Asia, suggesting lithosphere extension by rifting. Notably, the Japan and Yamato Basins show a comparable lithospheric thickness, although the crustal thickness beneath the Yamato Basin is known to be anomalously thick. This consistency in the lithospheric thickness implies that both basins undergo similar back-arc opening processes.
Three-dimensional inversion of audio-magnetotelluric data acquired from the crater area of Mt. Tokachidake, Japan
Authors: Tanaka Ryo , Yamaya Yusuke , Tamura Makoto , Hashimoto Takeshi , Okazaki Noritoshi , Takahashi Ryo , Mogi Toru 
Published: August 2021

AbstractSubvolcanic hydrothermal systems can lead to hydrothermal eruptions as well as unrest phenomena without an eruptive event. Historical eruptions and recent unrest events, including ground inflation, demagnetization, and a gradual decrease in the plume height, at Mt. Tokachidake, central Hokkaido, Japan, are related to such a subvolcanic hydrothermal system. This study investigates the three-dimensional (3-D) resistivity structure of Mt. Tokachidake to image its subvolcanic hydrothermal system. A 3-D inversion of the magnetotelluric data, acquired at 22 sites around the crater area, was performed while accounting for the topography. Our resistivity model was characterized by a high-resistivity layer at a shallow depth (50–100 m) and two conductors near the active crater and dormant crater. The high-resistivity layer was interpreted to be composed of dense lava, which acts as a caprock surrounding the conductor. The high conductivity beneath the active crater can be explained by the presence of hydrothermal fluid in fractured or leached zones within the low-permeability lava layer, as the sources of ground inflation and demagnetization were identified within the conductive zone immediately beneath the resistive layer. The resistivity structure was used to estimate the volume of hydrothermal fluid within the pore space. The minimum volume of hydrothermal fluid beneath the active crater that can explain the resistivity structure was estimated to be 3 × 106 m3. This estimate is comparable to the water volume that was associated with the long runout and highly fluidized lahar in 1926. The resistivity structure and volume of hydrothermal fluid presented in this study can be used as a reference for further numerical simulations, which aim to reveal the mechanisms of recent unrest events and assess the risk of hazards, such as lahar.
Influence of crustal lithology and the thermal state on microseismicity in the Wakayama region, southern Honshu, Japan
Authors: Maeda Sumire , Toda Shinji , Matsuzawa Toru , Otsubo Makoto , Matsumoto Takumi 
Published: August 2021

AbstractHere we investigate the influence of the lithology and thermal state of the upper crust on earthquake distributions beneath the Wakayama region, southern Honshu, Japan, to better understand the influence of crustal conditions on regional seismogenesis. The earthquakes are concentrated in the deeper sections of mafic belts and shallower sections of pelitic belts, based on a comparison of relocated hypocenters and estimated subsurface geological structures. We compare the frictional properties of pelitic rocks and basalt, as obtained from petrological experiments, with the hypocenter depth distributions in pelitic and mafic belts to assess the control of crustal lithology on the depth extent of regional seismicity. The earthquake distributions are consistent with the temperature ranges over which the respective rock types are expected to exhibit a velocity-weakening behavior, based on the petrological experiments. The results suggest that the occurrence of shallow intraplate earthquakes is controlled by the temperature- and lithology-dependent friction of the upper crust.