bluuebunny/crossref_metadata_2025_split huggingface dataset:
BCR-ABL1 (p210) Transcript Kinetics
Authors: Ng David P. , Karner Kristin Hunt 
Published: December 2021

Context.—
Delta checks are a powerful technique for monitoring clinical assays in many disciplines but have not been routinely used in molecular testing.

Objective.—
To determine if the biologically determined kinetics of BCR-ABL1's rise and fall could allow the development of a delta check in BCR-ABL1 testing.

Design.—
Nine years of BCR-ABL1 p210 results were evaluated, and patients with 3 or more results were selected for inclusion. The kinetics of these percentages of international standard values were plotted against time along with the median and the 90th and 95th percentile lines. A Monte Carlo simulation of a batch mix-up was performed for 6 months of data to determine the efficacy of the proposed cutoff.

Results.—
The median kinetics showed a 1-log drop of the percentage of international standard in 90 days, with less than 5% of cases showing faster than a 2-log drop in 90 days, and less than 2.5% showing a faster than 3-log drop in 90 days (extrapolated to 1 log in 30 days). The Monte Carlo simulation of a batch mix-up showed that an average batch mix-up of 23 samples could routinely be flagged by this cutoff, albeit with wide variance.

Conclusions.—
These results suggest that using a drop in the percentage of international standard of greater than 1 log in 30 days can be a useful trigger in implementing a delta-check system for this molecular test.
Nonlymphoid Hematopoietic Diseases Presenting in Bone, Soft Tissue, and Other Extranodal Sites
Authors: Cassidy Daniel P. , Rosenberg Andrew E. , Poveda Julio , Velez-Torres Jaylou , Chapman Jennifer 
Published: December 2021

Context.—
Although rare in everyday practice, the initial presentation of hematopoietic neoplasms other than lymphoma in the musculoskeletal system and other extranodal sites can generate challenging diagnostic problems for surgical pathologists.

Objective.—
To review the morphologic and immunophenotypic features of various nonlymphoid hematopoietic diseases presenting at extranodal sites, with emphasis on the inherent diagnostic pitfalls and differential diagnoses of these entities to aid surgical pathologists in their accurate recognition.

Data Sources.—
Cases reviewed herein represent both in-house and consult cases seen at our institution between 2010 and 2021.

Conclusions.—
Entities that present in this way include myeloid neoplasms and histiocytic/dendritic cell neoplasms. These tumors commonly cause nonspecific symptoms, and their histologic appearance can overlap with a variety of benign neoplasms and reactive processes. This can lead to delay in diagnosis and intervention with potentially lifesaving therapy; thus, accurate and expedient recognition is of paramount importance.
Tiger Nuts
Authors: El-Din Dina M. Ezz 
Published: December 2021

The importance of archaeobotany has been widely recognized in recent years, and more research is being conducted to study botanical remains. Only a very few of the cultivated vegetables grown in fields and in gardens were indigenous to Egypt, but one was the tiger nut (Cyperus esculentus L.) which was known and consumed since the Predynastic Period. Remains of dry tiger nuts tubers were found in large quantities in tombs from Neolithic times onwards. Some were found inside the stomachs of bodies as early as the Predynastic Period.
Tiger nuts are attested in funerary offering lists, festival offerings, in medicine and in diet. This paper sheds light on the importance of tiger nuts and its different uses. It also urges their use in modern Egypt.
Bipolar Electrochemistry
Authors: Bouffier Laurent , Zigah Dodzi , Sojic Neso , Kuhn Alexander 
Published: December 2021

Abstract
Bipolar electrochemistry (BPE) is a technique that involves two opposite chemical processes, namely an oxidation and a reduction, occurring simultaneously on the surface of a conducting object, usually without connection to a power supply. The basic phenomenon has already been described and used for many decades but regained a lot of interest in recent years, thanks to several attractive features for developing new applications in various areas ranging from materials science and analytical chemistry to catalysis and even life science. Consequently, BPE has experienced a substantial growth in the number of users and publications. This is mostly due to several advantages over classic electrochemistry, such as the absence of an ohmic contact, the generation of a directional gradient of electroactivity on the object, and the possibility to address simultaneously thousands of objects, which opens the door for high‐throughput screening of (electro)chemical properties. Also, some features of this “wireless” electrochemistry allow performing experiments that cannot be achieved with a classic electrochemical setup. Last but not least, only rather low‐cost equipment is needed.
The objective of the present contribution is to introduce first some fundamental aspects of BPE, and then to illustrate its different developments, highlighting not only the historic landmark achievements, but also the most recent findings, especially in the context of micro‐ and nanoscience. This article illustrates the singularities and advantages of this straightforward approach and hopefully convinces the reader of the power of this interesting electrochemical concept.
Waste‐to‐Energy: Microbial Fuel Cells as an Innovation Platform for Sustainable Development
Authors: Mecheri Barbara 
Published: December 2021

AbstractPromoting the transition toward a circular economy and sustainable development through scientific and technological innovation is the only viable strategy for leading to energy‐saving solutions, waste valorization, and efficient integration of renewable resources. Thanks to its dual function of harvesting energy from waste and cleaning up waste from organic pollutants, microbial fuel cells (MFCs) can be considered as a revolutionary tool for addressing the global environmental challenges. Here, several aspects of MFC technology are considered: basic principles and operational conditions, the role of materials efficiency for enhancing MFC performance, bacterial extracellular electron transfer mechanisms, the effect of different substrates used, and perspectives for technology scaling up.Special emphasis will be given to the development of low‐cost and effective catalysts for oxygen reduction reaction at the cathode side, as a key aspect for reducing the high cost of current electrode materials which limits the implementation of larger‐scale MFC systems. The application of MFCs in environmental monitoring and bioremediation is also reviewed, highlighting still existing limitations and potential future research for promoting the combination of MFCs with well‐established technologies.
Technical note: Partitioning of gated single photon emission computed tomography raw data for protocols optimization
Authors: Queiroz Cleiton Cavalcante , Machado Marcos Antonio Dorea , Ximenes Antonio Augusto Brito , Pino Andre Gustavo Silva , Netto Eduardo Martins 
Published: December 2021

AbstractPurposeMethodologies for optimization of SPECT image acquisition can be challenging due to imaging throughput, physiological bias, and patient comfort constraints. We evaluated a vendor‐independent method for simulating lower count image acquisitions.MethodsWe developed an algorithm that recombines the ECG‐gated raw data into reduced counting acquisitions. We then tested the algorithm to simulate reduction of counting statistics from phantom SPECT image acquisition, which was synchronized with an ECG simulator. The datasets were reconstructed with a resolution recovery algorithm and the summed stress score (SSS) was assessed by three readers (two experts and one automatic).ResultsThe algorithm generated varying counting levels, simulating multiple examinations at the same time. The error between the expected and the simulated countings ranged from approximately 5% to 10% for the ungated simulations and 0% for the gated simulations.ConclusionsThe vendor‐independent algorithm successfully generated lower counting statistics datasets from single‐gated SPECT raw data. This method can be readily implemented for optimal SPECT research aiming to lower the injected activity and/ or to shorten the acquisition time.
Boosting Reversibility and Stability of Li Storage in SnO2–Mo Multilayers: Introduction of Interfacial Oxygen Redistribution
Authors: Lan Xuexia , Cui Jie , Zhang Xiaofeng , Hu Renzong , Tan Liang , He Jiayi , Zhang Houpo , Xiong XingYu , Yang Xianfeng , Wu Shunqing , Zhu Min 
Published: December 2021

AbstractAmong the promising high‐capacity anode materials, SnO2 represents a classic and important candidate that involves both conversion and alloying reactions toward Li storage. However, the inferior reversibility of conversion reactions usually results in low initial Coulombic efficiency (ICE, ≈60%), small reversible capacity, and poor cycling stability. Here, it is demonstrated that by carefully designing the interface structure of SnO2–Mo, a breakthrough comprehensive performance with ultrahigh average ICE of 92.6%, large capacity of 1067 mA h g−1, and 100% capacity retention after 700 cycles can be realized in a multilayer Mo/SnO2/Mo electrode. Furthermore, high capacity retentions are also achieved in pouch‐type Mo/SnO2/Mo||Li half cells and Mo/SnO2/Mo||LiFePO4 full cells. The amorphous SnO2/Mo interfaces, which are induced by redistribution of oxygen between SnO2 and Mo, can precisely adjust the reversible capacity and cycling stability of the multilayers, while the stable capacities are parabolic with the interfacial density. Theoretical calculations and in/ex situ investigation reveal that oxygen redistribution in SnO2/Mo heterointerfaces boosts Li‐ion transport kinetics by inducing a built‐in electric field and improves the reaction reversibility of SnO2. This work provides a new understanding of interface–performance relationship of metal–oxide hybrid electrodes and pivotal guidance for creating high‐performance Li‐ion batteries.
A Wearable Microneedle‐Based Extended Gate Transistor for Real‐Time Detection of Sodium in Interstitial Fluids
Authors: Zheng Youbin , Omar Rawan , Zhang Rongjun , Tang Ning , Khatib Muhammad , Xu Qi , Milyutin Yana , Saliba Walaa , Broza Yoav Y. , Wu Weiwei , Yuan Miaomiao , Haick Hossam 
Published: December 2021

AbstractSodium is a prominent prognostic biomarker for assessing health status, such as dysnatremia. As of now, detection and monitoring of sodium levels in the human body is carried out by means of laborious and bulky laboratory equipmentand/or by offline analysis of various body fluids. Herein, an innovative stretchable, skin‐conformal and fast‐response microneedle extended‐gate FET biosensor is reported for real‐time detection of sodium in interstitial fluids for minimally invasive health monitoring along with high sensitivity, low limit of detection, excellent biocompatibility, and on‐body mechanical stability. The integration of the reported device with a wireless‐data transmitter and the Internet‐of‐Things cloud for real‐time monitoring and long‐term analysis is reported and discussed. This platform would eventually help bringing unlimited possibilities for effecient medical care and accurate clinical decision‐making.
In Situ Coupled Electrochemical‐Goniometry as a Tool to Reveal Conformational Changes of Charged Peptides
Authors: Ghafari Amir Mohammad , Domínguez Sergio E. , Järvinen Ville , Gounani Zahra , Schmit Amandine , Sjöqvist Marika , Sahlgren Cecilia , Salo‐Ahen Outi M. H. , Kvarnström Carita , Torsi Luisa , Österbacka Ronald 
Published: December 2021

AbstractThe opportunity to manipulate cell functions by regulating bioactive surfaces is a potentially promising approach for organic bioelectronics. Here, the tuning of the orientation of charged peptides by means of an electrical input observed via optical tensiometry is reported. A stimuli‐responsive self‐assembled monolayer (SAM) with specially designed charged peptides is used as a model system to switch between two separate hydrophilic states. The underwater contact angle (UCA) technique is used to measure changes in the wetting property of a dichloromethane droplet under electrical stimuli. The observed changes in the UCA of the bio‐interface can be understood in terms of a change in the surface energy between the ON and OFF states. Molecular dynamics simulations in an electric field have been performed to verify the hypothesis of the orientational change of the charged peptides upon electrical stimulation. In addition, X‐ray photoelectron spectroscopy (XPS) is performed to clarify the stability of the functionalized electrodes. Finally, the possibility of using such a novel switching system as a tool to characterize bioactive surfaces is discussed.
A Critical Review on Materials and Fabrications of Thermally Stable Separators for Lithium‐Ion Batteries
Authors: Wang Fenfen , Ke Xinyou , Shen Kang , Zhu Lei , Yuan Chris 
Published: December 2021

AbstractLi‐ion batteries nowadays are widely used as energy storage systems owing to their high power and energy densities. However, the safety of Li‐ion batteries has increasingly become a grave concern, and how to effectively mitigate or avoid the thermal runaway of Li‐ion batteries, particularly during fast charging/discharging, is a critical issue. It has been pointed out that among various factors governing the safety of Li‐ion batteries, the thermal stability of separators plays an important role. In this review, a critical discussion is reported on recent research and development of thermally stable separators, including surface modified polyolefin separators, novel polymer separators, inorganic structured separators, and functional smart separators, for improving the safety of Li‐ion batteries, summarizing different techniques, processes, and materials being researched and developed for these separators for lithium‐ion batteries. Finally, suggestions are provided on future directions to develop thermally stable separators with respect to the safety of next‐generation Li‐ion batteries.
Edible Amorphous Structural Color
Authors: Chu Jiao , Chen Yan , Tan Shi‐Ying , Liu Yuan‐Yuan , Liu Wenzhe , Liu Xiaohan , Shi Lei , Wang Haifang , Li Wei , Zi Jian 
Published: December 2021

AbstractDue to the scarcity of blue color in the natural food palette, synthetic blue edible colorants are commonly used in daily life. With growing awareness of environmental hazards and potential side‐effect impacts of synthetic food colorants on customers’ health, synthetic blue edible colorants are no longer a good choice. Here, a strategy of mixing two edible sub‐microspheres, mesoporous hollow TiO2 sub‐microspheres or SiO2 sub‐microspheres and cuttlefish ink particles, is reported to produce mass amorphous photonic structures (APSs) with structural color. The hues can be tuned by controlling the size of mesoporous hollow TiO2 sub‐microspheres, and the saturation is strongly related to the proportion of cuttlefish ink particles. Cytotoxicity assays and evaluation of bioaccessibility in the simulated human digestive system further prove the safety of the blue structural colorants. The blue structural colorants exhibit high color visibility, thermostability, and reliable food safety, which are promising properties for food, drugs, and cosmetics.
Physiological quality of peanut seed affected by tomato spotted wilt disease
Authors: Suassuna Tais M. F. , Grey Timothy Lane , Luo Xuelin , Culbreath Albert K. , Pilon Cristiane 
Published: December 2021

AbstractTomato spotted wilt disease (TSW) caused by tomato spotted wilt virus (TSWV) (genus Orthotospovirus) is a relevant disease in the peanut (Arachis hypogaea L.) crop. The effects of TSW in the plant are well documented. However, its effect on the seed physiology is unknown. The objective of this study was to evaluate the vigor and germination of peanut seeds from different genotypes with TSW symptoms. One cultivar and six germplasm lines related to A. ipaënsis Krapov. & W.C. Gregory and A. duranensis Krapov. & W.C. Gregory in addition to two U.S. cultivars (resistant and susceptible checks) were evaluated. Seeds were separated into symptomatic and asymptomatic classes. The mass of 100 seeds varied from 31 to 72 g among the genotypes. Germination and vigor were assessed by using a thermal gradient table (12–32 °C). Seeds that did not germinate during the test on the table were transferred to an incubator at 25 °C for three additional days to quantify total germination. Seed vigor was high across all genotypes and symptomology classes. Total germination was reduced for seeds kept at low temperature (12–16 °C) in the thermal table, regardless of genotype or symptomology. Overall, TSW symptoms did not affect germination, vigor, and seed size negatively.
Spatial heterogeneity of soil nutrients in black soil areas of Northeast China
Authors: Ba Zhidan , Wang Jingfa , Song Chunwei , Du Huishi 
Published: December 2021

AbstractExploring the distribution and evolution of soil nutrients, it is needed to maintain quality of land and ensure food production. Based on geostatistical theory, 1,054 soil sites were selected from the surface (0–20 cm) of the typical black soil area in Northeast China. The spatial structure of soil pH, alkali‐hydrolyzed N, effective P, and available K was investigated using Kriging and spatial statistics. The soils in the study area are acidic, alkali‐hydrolyzed N, effective P, and available K content at moderate to high levels. Coefficients of variation for various nutrients ranged from 5 to 80%, all showing moderate variation. The pH, alkali‐hydrolyzed N, effective P, and available K increased from South to North, the value of soil nutrients near the city were high. The results provide reference values for future work targeted at improving food security and reducing the effect on the environment.
Tetramethylammonium Iodide (TMAI)‐Promoted Sulfenylation/Annulation of Enaminones with Thiosulfonates
Authors: Zhang De‐Run , Hu Lin‐Ping , Yang Cai‐Yun , Li Xia , Teng Ming‐Yu , Liu Bo , Huang Guo‐Li 
Published: December 2021

AbstractA highly efficient and eco‐friendly method for the tetramethylammonium iodide‐mediated sulfenylation/annulation of enaminones using thiosulfonates as the sulfenyl source was described under open‐air, metal‐, and oxidant‐free conditions. This method provides an alternative way of constructing C−S bonds, affords various substituted sulfenylated chromones in moderate to good yields, and shows broad substrate scope, and good functional group tolerance.
Green‐Chemistry‐Inspired Synthesis of Cyclobutane‐Based Hole‐Selective Materials for Highly Efficient Perovskite Solar Cells and Modules
Authors: Daskeviciute‐Geguziene Sarune , Zhang Yi , Rakstys Kasparas , Kreiza Gediminas , Khan Sher Bahadar , Kanda Hiroyuki , Paek Sanghyun , Daskeviciene Maryte , Kamarauskas Egidijus , Jankauskas Vygintas , Asiri Abdullah M. , Getautis Vytautas , Nazeeruddin Mohammad Khaja 
Published: December 2021

AbstractHybrid lead halide perovskite solar cells (PSCs) have emerged as potential competitors to silicon‐based solar cells with an unprecedented increase in power conversion efficiency (PCE), nearing the breakthrough point toward commercialization. However, for hole‐transporting materials, it is generally acknowledged that complex structures often create issues such as increased costs and hazardous substances in the synthetic schemes, when translated from the laboratory to manufacture on a large scale. Here, we present cyclobutane‐based hole‐selective materials synthesized using simple and green‐chemistry inspired protocols in order to reduce costs and adverse environmental impact. A series of novel semiconductors with molecularly engineered side arms were successfully applied in perovskite solar cells. V1366‐based PSCs feature impressive efficiency of 21 %, along with long‐term operational stability under atmospheric environment. Most importantly, we also fabricated perovskite solar modules exhibiting a record efficiency over 19 % with an active area of 30.24 cm2.
Dual Active Centers Bridged by Oxygen Vacancies of Ruthenium Single‐Atom Hybrids Supported on Molybdenum Oxide for Photocatalytic Ammonia Synthesis
Authors: Yin Haibo , Chen Zhen , Peng Yue , Xiong Shangchao , Li Yadong , Yamashita Hiromi , Li Junhua 
Published: December 2021

AbstractPhotocatalytic synthesis of ammonia (NH3) holds significant potential compared with the Haber–Bosch process. However, the reported photocatalysts suffer from low efficiency owing to localized electron deficiency. Herein, Ru‐SA (single atoms)/HxMoO3−y hybrids with abundant of Mon+ (4<n<6) species neighboring oxygen vacancies (OV) are synthesized via a H‐spillover process. Detailed characterizations demonstrate that Ru‐SA/HxMoO3−y hybrids can quantitatively produce NH3 from N2 and H2 through the presence of dual active centers (Ru SA and Mon+). The Ru SA boost the activation and migration of H2, and Mon+ species act as the trapping sites of localized electrons and the adsorption and dissociation sites of N2, finally leading to NH3 synthesis on Mon+−OH. The NH3 generation rate is up to 4.0 mmol h−1 g−1, accompanied by an apparent quantum efficiency over 6.0 % at 650 nm.
Stabilization of Polyoxometalate Charge Carriers via Redox‐Driven Nanoconfinement in Single‐Walled Carbon Nanotubes
Authors: Jordan Jack W. , Cameron Jamie M. , Lowe Grace A. , Rance Graham A. , Fung Kayleigh L. Y. , Johnson Lee R. , Walsh Darren A. , Khlobystov Andrei N. , Newton Graham N. 
Published: December 2021

AbstractWe describe the preparation of hybrid redox materials based on polyoxomolybdates encapsulated within single‐walled carbon nanotubes (SWNTs). Polyoxomolybdates readily oxidize SWNTs under ambient conditions in solution, and here we study their charge‐transfer interactions with SWNTs to provide detailed mechanistic insights into the redox‐driven encapsulation of these and similar nanoclusters. We are able to correlate the relative redox potentials of the encapsulated clusters with the level of SWNT oxidation in the resultant hybrid materials and use this to show that precise redox tuning is a necessary requirement for successful encapsulation. The host–guest redox materials described here exhibit exceptional electrochemical stability, retaining up to 86 % of their charge capacity over 1000 oxidation/reduction cycles, despite the typical lability and solution‐phase electrochemical instability of the polyoxomolybdates we have explored. Our findings illustrate the broad applicability of the redox‐driven encapsulation approach to the design and fabrication of tunable, highly conductive, ultra‐stable nanoconfined energy materials.