bluuebunny/crossref_metadata_2025_split huggingface dataset:
Affect-Based Problem Drinking Risk: The Reciprocal Relationship between Affective Lability and Problem Drinking
Authors: Peterson Sarah J , Atkinson Emily A , Riley Elizabeth N , Davis Heather A , Smith Gregory T 
Published: March 2021

Abstract

Aims
Negative affect has been implicated in risk for the development of problematic drinking behavior. Furthermore, there is evidence for reciprocal relationships between negative affect and problem drinking, such that engagement in problem drinking also predicts increases in negative affect. However, affective models of risk often fail to consider affective lability—the experience of rapidly changing mood. Although affective lability appears to increase risk for problem drinking, it is unknown if this relationship persists above and beyond other affect-related constructs (e.g. depression, anxiety) and if it is reciprocal in nature. Accordingly, we used a longitudinal survey design to examine (a) if affective lability predicts problem drinking above and beyond depression and anxiety and (b) if affective lability and problem drinking demonstrate a reciprocal relationship.

Methods
First-year college students (n = 358) participated in a three wave longitudinal study. We constructed a structural equation model (SEM) of a random intercept cross-lagged panel model to test our hypotheses.

Results
Consistent with our hypotheses, affective lability predicted increases in problem drinking while anxiety and depression did not. Problem drinking and affective lability demonstrated a reciprocal relationship in which increases in one predicted increases in the other at subsequent time points. This relationship was present beyond the predictive effects of anxiety or depression.

Conclusions
Affective lability appears to be an important affect-based predictor of problem drinking, and there may be a reciprocal, risk-enhancing relationship between affective lability and problem drinking.
Components of negative affect, such as depression or anxiety, have been shown to predict risk for problem drinking, and vice versa. A less considered construct, affective lability, predicted problem drinking while anxiety and depression did not add any predictive power. Problem drinking and affective lability also appeared to demonstrate a reciprocal relationship.
A Mixed-Methods Analysis of Family Perceptions of Neuropsychological Evaluation and Resources for Pediatric Brain Tumor Survivors
Authors: Moscato Emily L , Fisher Allison P , Gies Lisa M , Smith-Paine Julia M , Miley Aimee E , Beebe Dean W , Quinton Thea L , Pai Ahna L H , Salloum Ralph , Wade Shari L 
Published: March 2021

Abstract

Objective
Neuropsychological testing is often recommended for pediatric brain tumor survivors, yet little is known about perceptions of testing and resources. The purpose of this study is to examine survivor and caregiver perceptions about neuropsychology and resources and identify factors associated with receipt of neuropsychological testing.

Method
Survivors and their families (N = 55) completed questionnaires on demographics and family functioning. The Neurological Predictive Scale was used to rate treatment intensity and expected impact on neuropsychological functioning. Chi squares and logistic regression were used to examine the associations between demographic, disease, and treatment factors and receipt of neuropsychological testing. Qualitative interviews (N = 25) were completed with a subset of families and coded with thematic content analysis and a multicoder consensus process with high inter-rater reliability (kappas .91–.93).

Results
The majority of survivors received neuropsychological testing. Survivors were more likely to receive neuropsychological testing if they were younger and if their caregivers had less than a college education and lower income. Qualitatively, families identified neurocognitive concerns. Some families reported that neuropsychological testing was helpful in clarifying deficits or gaining accommodations, while other families had difficulty recalling results or identified barriers to services. To mitigate the impact of deficits, families implemented metacognitive strategies and advocated for their survivor at school. Families desired more resources around the transition to adulthood and more opportunities for connection with other survivors.

Conclusions
Many families valued insights from neuropsychological services yet identified room for further improvement to address barriers and ensure accessibility and comprehensibility of neuropsychological findings.
The role of increased FGF21 in VLDL-TAG secretion and thermogenic gene expression in mice under protein malnutrition
Authors: Ozaki-Masuzawa Yori , Kosaka Hiroki , Abiru Rino , Toda Yumiko , Kawabata Kota , Nagata Mari , Hara Shohei , Konishi Morichika , Itoh Nobuyuki , Hosono Takashi , Takenaka Asako , Seki Taiichiro 
Published: March 2021

ABSTRACT
Protein malnutrition promotes hepatic lipid accumulation in growing animals. In these animals, fibroblast growth factor 21 (FGF21) rapidly increases in the liver and circulation and plays a protective role in hepatic lipid accumulation. To investigate the mechanism by which FGF21 protects against liver lipid accumulation under protein malnutrition, we determined whether upregulated FGF21 promotes the thermogenesis or secretion of very-low-density lipoprotein (VLDL)–triacylglycerol (TAG). The results showed that protein malnutrition decreased VLDL-TAG secretion, but the upregulation of FGF21 did not oppose this effect. In addition, protein malnutrition increased expression of the thermogenic gene uncoupling protein 1 in inguinal white adipose and brown adipose tissue in an FGF21-dependent manner. However, surgically removing inguinal white adipose tissue did not affect liver triglyceride levels in protein-malnourished mice. These data suggest that FGF21 stimulates thermogenesis under protein malnutrition, but this is not the causative factor underlying the protective role of FGF21 against liver lipid accumulation.
Early life experience influences dispersal in coyotes (Canis latrans)
Authors: Zepeda Emily , Payne Eric , Wurth Ashley , Sih Andrew , Gehrt Stanley 
Published: March 2021

AbstractNatal dispersal plays an important role in connecting individual animal behavior with ecological processes at all levels of biological organization. As urban environments are rapidly increasing in extent and intensity, understanding how urbanization influences these long distance movements is critical for predicting the persistence of species and communities. There is considerable variation in the movement responses of individuals within a species, some of which is attributed to behavioral plasticity which interacts with experience to produce interindividual differences in behavior. For natal dispersers, much of this experience occurs in the natal home range. Using data collected from VHF collared coyotes (Canis latrans) in the Chicago Metropolitan Area we explored the relationship between early life experience with urbanization and departure, transience, and settlement behavior. Additionally, we looked at how early life experience with urbanization influenced survival to adulthood and the likelihood of experiencing a vehicle related mortality. We found that coyotes with more developed habitat in their natal home range were more likely to disperse and tended to disperse farther than individuals with more natural habitat in their natal home range. Interestingly, our analysis produced mixed results for the relationship between natal habitat and habitat selection during settlement. Finally, we found no evidence that early life experience with urbanization influenced survival to adulthood or the likelihood of experiencing vehicular mortality. Our study provides evidence that early life exposure influences dispersal behavior; however, it remains unclear how these differences ultimately affect fitness.
The evolution of primate coloration revisited
Authors: Caro Tim , Brockelsby Kasey , Ferrari Annie , Koneru Manisha , Ono Konatsu , Touche Edward , Stankowich Theodore 
Published: March 2021

AbstractPrimates are noted for their varied and complex pelage and bare skin coloration but the significance of this diverse coloration remains opaque. Using new updated information, novel scoring of coat and skin coloration, and controlling for shared ancestry, we reexamined and extended findings from previous studies across the whole order and the five major clades within it. Across primates, we found (i) direct and indirect evidence for pelage coloration being driven by protective coloration strategies including background matching, countershading, disruptive coloration, and aposematism, (ii) diurnal primates being more colorful, and (iii) the possibility that pelage color diversity is negatively associated with female trichromatic vision; while (iv) reaffirming avoidance of hybridization driving head coloration in males, (v) darker species living in warm, humid conditions (Gloger’s rule), and (vi) advertising to multiple mating partners favoring red genitalia in females. Nonetheless, the importance of these drivers varies greatly across clades. In strepsirrhines and cercopithecoids, countershading is important; greater color diversity may be important for conspecific signaling in more diurnal and social strepsirrhines; lack of female color vision may be associated with colorful strepsirrhines and platyrrhines; whereas cercopithecoids obey Gloger’s rule. Haplorrhines show background matching, aposematism, character displacement, and red female genitalia where several mating partners are available. Our findings emphasize several evolutionary drivers of coloration in this extraordinarily colorful order. Throughout, we used coarse but rigorous measures of coloration, and our ability to replicate findings from earlier studies opens up opportunities for classifying coloration of large numbers of species at a macroevolutionary scale.
Framing Migrant Resilience as a Civic Responsibility: A Case Study of Municipal and Provincial Immigrant Integration Policies in Toronto, Ontario
Authors: Bhuyan Rupaleem , Leung Vivian W Y 
Published: March 2021

Abstract
This article presents a case study of how regional and municipal governments in Toronto, Ontario, use the concept of resilience to frame the challenges faced by immigrants and the steps governments are taking to promote immigrant integration. In the past decade, resilience has emerged as a policy framework to encourage positive adaptation of people and institutions that are facing social, economic and environmental challenges associated with population growth and economic globalisation. As a policy discourse, the concept of resilience is used to identify which immigrants need social and psychological support to better cope with pre- and post-migration stressors. Although government discourse acknowledges some of the structural inequities migrants face that require resilience (e.g. poverty, systemic racism, precarious employment), the discourse on migrant resilience notably omits government responsibility to enact structural solutions. Even the City of Toronto’s anti-racism campaign, which seeks to reduce racial bias and discrimination against immigrants, frames ‘civic resilience’ as an individual responsibility. Despite the promise of resilience to emphasise immigrants’ capabilities, we argue that resilience discourse operates as a type of diversity management strategy to identify which immigrants warrant government support to maximise their economic contributions to the region.
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice
Authors: Caló Laura , Hidari Eric , Wegrzynowicz Michal , Dalley Jeffrey W , Schneider Bernard L , Podgajna Martyna , Anichtchik Oleg , Carlson Emma , Klenerman David , Spillantini Maria Grazia 
Published: March 2021

Abstract
α-Synuclein aggregation at the synapse is an early event in Parkinson’s disease and is associated with impaired striatal synaptic function and dopaminergic neuronal death. The cysteine string protein (CSPα) and α-synuclein have partially overlapping roles in maintaining synaptic function and mutations in each cause neurodegenerative diseases. CSPα is a member of the DNAJ/HSP40 family of co-chaperones and like α-synuclein, chaperones the SNARE complex assembly and controls neurotransmitter release. α-Synuclein can rescue neurodegeneration in CSPαKO mice. However, whether α-synuclein aggregation alters CSPα expression and function is unknown. Here we show that α-synuclein aggregation at the synapse is associated with a decrease in synaptic CSPα and a reduction in the complexes that CSPα forms with HSC70 and STGa. We further show that viral delivery of CSPα rescues in vitro the impaired vesicle recycling in PC12 cells with α-synuclein aggregates and in vivo reduces synaptic α-synuclein aggregates increasing monomeric α-synuclein and restoring normal dopamine release in 1-120hαSyn mice. These novel findings reveal a mechanism by which α-synuclein aggregation alters CSPα at the synapse, and show that CSPα rescues α-synuclein aggregation-related phenotype in 1-120hαSyn mice similar to the effect of α-synuclein in CSPαKO mice. These results implicate CSPα as a potential therapeutic target for the treatment of early-stage Parkinson’s disease.
Failure to engage the temporoparietal junction/posterior superior temporal sulcus predicts impaired naturalistic social cognition in schizophrenia
Authors: Patel Gaurav H , Arkin Sophie C , Ruiz-Betancourt Daniel R , Plaza Fabiola I , Mirza Safia A , Vieira Daniel J , Strauss Nicole E , Klim Casimir C , Sanchez-Peña Juan P , Bartel Laura P , Grinband Jack , Martinez Antigona , Berman Rebecca A , Ochsner Kevin N , Leopold David A , Javitt Daniel C 
Published: March 2021

AbstractSchizophrenia is associated with marked impairments in social cognition. However, the neural correlates of these deficits remain unclear. Here we use naturalistic stimuli to examine the role of the right temporoparietal junction/posterior superior temporal sulcus (TPJ-pSTS)—an integrative hub for the cortical networks pertinent to the understanding complex social situations—in social inference, a key component of social cognition, in schizophrenia. Twenty-seven schizophrenia participants and 21 healthy control subjects watched a clip of the film The Good, the Bad and the Ugly while high resolution multiband functional MRI images were collected. We used inter-subject correlation to measure the evoked activity, which we then compared to social cognition as measured by The Awareness of Social Inference Test (TASIT). We also compared between groups the TPJ-pSTS blood oxygen level-dependent activity (i) relationship with the motion content in the film; (ii) synchronization with other cortical areas involved in the viewing of the movie; and (iii) relationship with the frequency of saccades made during the movie. Activation deficits were greatest in middle TPJ (TPJm) and correlated significantly with impaired TASIT performance across groups. Follow-up analyses of the TPJ-pSTS revealed decreased synchronization with other cortical areas, decreased correlation with the motion content of the movie, and decreased correlation with the saccades made during the movie. The functional impairment of the TPJm, a hub area in the middle of the TPJ-pSTS, predicts deficits in social inference in schizophrenia participants by disrupting the integration of visual motion processing into the TPJ. This disrupted integration then affects the use of the TPJ to guide saccades during the visual scanning of the movie clip. These findings suggest that the TPJ may be a treatment target for improving deficits in a key component of social cognition in schizophrenia participants.
A Bayesian optimization approach for rapidly mapping residual network function in stroke
Authors: Lorenz Romy , Johal Michelle , Dick Frederic , Hampshire Adam , Leech Robert , Geranmayeh Fatemeh 
Published: March 2021

AbstractPost-stroke cognitive and linguistic impairments are debilitating conditions, with limited therapeutic options. Domain-general brain networks play an important role in stroke recovery and characterizing their residual function with functional MRI has the potential to yield biomarkers capable of guiding patient-specific rehabilitation. However, this is challenging as such detailed characterization requires testing patients on multitudes of cognitive tasks in the scanner, rendering experimental sessions unfeasibly lengthy. Thus, the current status quo in clinical neuroimaging research involves testing patients on a very limited number of tasks, in the hope that it will reveal a useful neuroimaging biomarker for the whole cohort. Given the great heterogeneity among stroke patients and the volume of possible tasks this approach is unsustainable. Advancing task-based functional MRI biomarker discovery requires a paradigm shift in order to be able to swiftly characterize residual network activity in individual patients using a diverse range of cognitive tasks. Here, we overcome this problem by leveraging neuroadaptive Bayesian optimization, an approach combining real-time functional MRI with machine-learning, by intelligently searching across many tasks, this approach rapidly maps out patient-specific profiles of residual domain-general network function. We used this technique in a cross-sectional study with 11 left-hemispheric stroke patients with chronic aphasia (four female, age ± standard deviation: 59 ± 10.9 years) and 14 healthy, age-matched control subjects (eight female, age ± standard deviation: 55.6 ± 6.8 years). To assess intra-subject reliability of the functional profiles obtained, we conducted two independent runs per subject, for which the algorithm was entirely reinitialized. Our results demonstrate that this technique is both feasible and robust, yielding reliable patient-specific functional profiles. Moreover, we show that group-level results are not representative of patient-specific results. Whereas controls have highly similar profiles, patients show idiosyncratic profiles of network abnormalities that are associated with behavioural performance. In summary, our study highlights the importance of moving beyond traditional ‘one-size-fits-all’ approaches where patients are treated as one group and single tasks are used. Our approach can be extended to diverse brain networks and combined with brain stimulation or other therapeutics, thereby opening new avenues for precision medicine targeting a diverse range of neurological and psychiatric conditions.
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Children in Summer Schools Applying Stringent Control Measures in Barcelona, Spain
Authors: Jordan Iolanda , Fernandez de Sevilla Mariona , Fumado Victoria , Bassat Quique , Bonet-Carne Elisenda , Fortuny Claudia , Garcia-Miquel Aleix , Jou Cristina , Adroher Cristina , Melé Casas María , Girona-Alarcon Mònica , Hernández Garcia María , Pons Tomas Gemma , Ajanovic Sara , Arias Sara , Balanza Núria , Baro Bárbara , Millat-Martinez Pere , Varo Rosauro , Alonso Sergio , Álvarez-Lacalle Enric , López Daniel , Claverol Joana , Cubells Marta , Brotons Pedro , Codina Anna , Cuadras Daniel , Bruijning-Verhagen Patricia , Faust Saul , Munro Alasdair , Muñoz-Almagro Carmen , Català Martí , Prats Clara , Garcia-Garcia Juan José , Gratacós Eduard 
Published: March 2021

Abstract

Background
Understanding the role of children in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is critical to guide decision-making for schools in the pandemic. We aimed to describe the transmission of SARS-CoV-2 among children and adult staff in summer schools.

Methods
During July 2020, we prospectively recruited children and adult staff attending summer schools in Barcelona who had SARS-CoV-2 infection. Primary SARS-CoV-2 infections were identified through (1) a surveillance program in 22 summer schools of 1905 participants, involving weekly saliva sampling for SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) during 2–5 weeks; and (2) cases identified through the Catalonian Health Surveillance System of children diagnosed with SARS-CoV-2 infection by nasopharyngeal RT-PCR. All centers followed prevention protocols: bubble groups, handwashing, face masks, and conducting activities mostly outdoors. Contacts of a primary case within the same bubble were evaluated by nasopharyngeal RT-PCR. Secondary attack rates and the effective reproduction number in summer schools (Re*) were calculated.

Results
Among the &gt;2000 repeatedly screened participants, 30 children and 9 adults were identified as primary cases. A total of 253 close contacts of these primary cases were studied (median, 9 [interquartile range, 5–10] for each primary case), among which 12 new cases (4.7%) were positive for SARS-CoV-2. The Re* was 0.3, whereas the contemporary rate in the general population from the same areas in Barcelona was 1.9.

Conclusions
The transmission rate of SARS-CoV-2 infection among children attending school-like facilities under strict prevention measures was lower than that reported for the general population. This suggests that under preventive measures schools are unlikely amplifiers of SARS-CoV-2 transmission, supporting current recommendations for school opening.
Multivariate Hawkes process analysis of posts on a web service about uncomfortable gender experiences
Authors: Goda Masatoshi , Yano Ryosuke , Mizuno Takayuki 
Published: March 2021

Abstract
We propose a method for the modelling of the propagation of text data in web site space among some groups by using a multivariate Hawkes process with a sparse structure. For estimation, we introduced a hybrid method using a quasi-maximum likelihood estimator (QMLE) and a $L^1$-penalized QMLE. As a real example, we investigated posts on a Japanese web service about uncomfortable gender experiences, which we classified into 12 groups by age and sex, and we calculated the magnitude of the correlation between each group. In addition, we visualized the propagation structure of posts in each group by summarizing the results in a directed Hawkes graph and a heat map of time integrals of kernel functions.
HVSR analysis of a layered saturated half-space using diffuse-field theory
Authors: Ba Zhenning , Sang Qiaozhi , Liang Jianwen , Wu Mengtao 
Published: March 2021

SUMMARYThe recently constructed diffuse field theory from isotropic energy equipartition has been well developed in elasticity for full-wave interpretation of horizontal-to-vertical ratio (HVSR), which links the signal autocorrelation with the imaginary part of Green's function. Here, the theory is extended to the saturated layered medium within the framework of Biot's theory to account for the offshore environment. The imaginary parts of Green's functions are obtained using direct stiffness method accompanied with Fourier–Hankel transform. In particular, the upgoing wave amplitudes are modified to tackle the overflow during wavenumber integral and allow for fast calculations. After validating the method from the perspectives of Green's function calculation, emphasis is laid on evaluating the inaccuracies of HVSR calculation induced by model misuses in the lack of prior geological and geotechnical information. The numerical results considering the effects of layer sequence, impedance ratio, porosity and drainage condition show that the predominant frequency of the one-phase medium is slightly less than the two-phase medium with the maximum shift no more than 0.1 Hz, while their amplitude differences can be prominent as impedance ratio and porosity increase, with the maximum difference up to 29 per cent. The shallowest soft layer has the dominant effects on HVSR amplitudes, whereas the buried low-velocity layer at depth over one-wavelength contributes little to the peak amplitude. Finally, the method is applied to a realistic case at Mirandola, Northorn Italy, which suffered extensive liquefaction-induced damages in 2012 Emilia earthquake. The well identified pattern of the experimental HVSR using the two-phase medium model illustrates the application potential of our method to further assist the subsurface geology retrieval.