bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model
Authors: Liu Chiung‐Hui , Liao Wen‐Chieh , Li Hsin‐Hua , Tseng Li‐Ho , Wang Wei‐Han , Tung Hsin , Lin Pin‐Jiun , Jao Hsin‐Tung , Liu Wen‐Yuan , Hung Ching‐Sui , Lin Chih‐Li , Ho Ying‐Jui 
Published: September 2021

AbstractEpilepsy, which is caused by abnormal neuronal firing in the brain, is a common neurological disease and affects motor and cognitive functions. Excessive levels of glutamate and insufficient levels of inhibitory GABA are involved in its pathophysiology. Valproic acid (Val), a GABAergic agonist, is one of the first‐line antiepileptic drugs, but it shows many adverse side effects at the clinical dose. Clavulanic acid (CA), a β‐lactamase inhibitor, has been demonstrated to increase glutamate transporter‐1 expression. This study evaluated the effects of CA and Val in an epilepsy rat model. Male Wistar rats received intraperitoneal injections of pentylenetetrazol (PTZ, 35 mg/kg, every other day, IP, for 13 days) to induce kindling epilepsy. After four times of PTZ injection, rats received daily treatment with CA (1 or 10 mg/kg, IP), Val (50 or 100 mg/kg, IP), or the combination of CA (1 mg/kg) and Val (50 mg/kg) for 7 consecutive days. Motor, learning, and memory functions were measured. Rats with PTZ‐induced kindling exhibited seizures, motor dysfunction, cognitive impairment, and cell loss and reduction of neurogenesis in the hippocampus. Neither 1 mg/kg CA nor 50 mg/kg Val treatment was effective in alleviating behavioral and neuronal deficits. However, treatment with 10 mg/kg CA, 100 mg/kg Val, and the combination of 1 mg/kg CA and 50 mg/kg Val improved these behavioral and neuronal deficits. Particularly, the combination of CA and Val showed synergistic effects on seizure suppression, suggesting the potential for treating epilepsy and related neuronal damage and motor and cognitive deficits.
Individual social capital and dental pain in older adults
Authors: do Amaral Júnior Orlando Luiz , Braccini Fagundes Maria Laura , Menegazzo Gabriele Rissotto , Melgarejo do Amaral Giordani Jessye 
Published: September 2021

AbstractObjectivesTo investigate the association between the structural and cognitive dimensions of social capital and dental pain in Brazilian adults aged 50 years and over.MethodsThis cross‐sectional study conducted individual assessments of 6154 Brazilians aged 50 years or older. Four individual variables based on structural and cognitive dimensions of social capital were assessed. We used hierarchical logistic regression models to estimate the odds ratio for dental pain with individual structural and cognitive social capital variables adjusted for associated factors. The model followed hypothetical pathways linking social capital to oral health.ResultsCognitive social capital was associated with dental pain. Participants who did not trust their neighbourhood had a 28% greater chance (OR, 1.28; 95% CI, 1.02‐1.60) of dental pain than those who did.ConclusionElements of cognitive dimension of social capital, particularly trust, reciprocity and support, as part of a common risk factor approach, should be considered when planning oral health promotion and preventive activities for older people.
Concepts for the Revitalisation of Critical Criminology
Authors: RUGGIERO VINCENZO 
Published: September 2021

AbstractWhat survives of the notions, principles and values of critical criminology? Faced with contexts that could not be more dramatically different from those fostering critical approaches to crime and its control, what is left of the radical theories and practical initiatives that characterised it in the 1970s? This article does not offer a history of critical criminology or a survey of contemporary debates in the area. Rather, it suggests a number of concepts in the form of variables (or thematic areas) through which novel critical views of crime and its control can be elaborated. Throughout, the article will refer to the contribution of early critical criminology only in relation to the concepts proposed.
Fast Fashion: A Case of Social Harm and State‐Corporate Crime
Authors: SIMONČIČ KATJA 
Published: September 2021

AbstractIn this article, harm that occurs as a consequence of inadequate health and safety conditions in the production of fast fashion is highlighted as a representative example of a practice that is harmful, yet normalised in the context of neoliberal capitalism. This harmful practice is analysed with the help of two concepts which originate from critical criminology: the concept of social harm as defined by Pemberton (2016) as well as Michalowski and Kramer's (2007) concept of state‐corporate crime. The article aims to emphasise the criminological relevance of harmful, yet normalised practices such as fast fashion and to demonstrate the usefulness of the two concepts to do so.
Critical Criminology: State‐Facilitated Corporate Crime, Environmental Racism, and the Atlantic Coast Pipeline
Authors: PEDIGO KULZER SARAH , PITMAN BRIAN , YOUNG STEPHEN T. 
Published: September 2021

AbstractCritical criminology continues to focus on the intersections of race, class, and green harms, as this analysis provides a more complete framework for understanding the role of state violence in capitalist projects. This article utilises the frameworks of environmental racism and state‐facilitated corporate crime to analyse the proposed 600‐mile natural gas pipeline, the Atlantic Coast Pipeline (ACP). We focus on the narratives of the corporations and state in pursuing the project, including dispelling the myth that natural gas is ‘clean’. We also highlight the project's disproportionate social and environmental impact on poor and black, Indigenous, and people of colour (BIPOC) communities. We end by discussing the state's role in facilitating the project through the Federal Energy Regulatory Commission (FERC).
Evaluation of Scopio Labs X100 Full Field PBS: The first high‐resolution full field viewing of peripheral blood specimens combined with artificial intelligence‐based morphological analysis
Authors: Katz Ben‐Zion , Feldman Michael D. , Tessema Minychel , Benisty Dan , Toles Grace Stewart , Andre Alicia , Shtreker Bronka , Paz Fatima Maria , Edwards Joshua , Jengehino Darrin , Bagg Adam , Avivi Irit , Pozdnyakova Olga 
Published: September 2021

AbstractBackgroundCurrent digital cell imaging systems perform peripheral blood smear (PBS) analysis in limited regions of the PBS and require the support of manual microscopy without achieving full digital microscopy. We report a multicenter study that validated the Scopio Labs X100 Full Field PBS, a novel digital imaging system that utilizes a full field view approach for cell recognition and classification, in a decision support system mode.MethodsWe analyzed 335 normal and 310 abnormal PBS from patients with various clinical conditions and compared the performance of Scopio's Full Field PBS as the test method, with manual PBS analysis as the reference method. Deming regression analysis was utilized for comparisons of WBC and platelet estimates. Measurements of WBC and platelet estimation accuracy along with the agreement on RBC morphology evaluation were performed. Reproducibility and repeatability (R&R) of the system were also evaluated.ResultsScopio's Full Field PBS WBC accuracy was evaluated with an efficiency of 96.29%, sensitivity of 87.86%, and specificity of 97.62%. The agreement between the test and reference method for RBC morphology reached 99.77%, and the accuracy for platelet estimation resulted in an efficiency of 94.89%, sensitivity of 90.00%, and specificity of 96.28%, with successful R&R tests. The system enabled a comprehensive review of full field PBS as shown in representative samples.ConclusionsScopio's Full Field PBS showed a high degree of correlation of all tested parameters with manual microscopy. The novel full field view of specimens facilitates the long‐expected disengagement between the digital application and the manual microscope.
Risk assessment and classification for foot ulceration among patients with type 2 diabetes in South Korea
Authors: Lee Eun Joo , Jeong Ihn Sook , Kim In Ju , Cho Young Hye , Kim Yun Jin 
Published: September 2021

AbstractAimThis study aimed to investigate the distribution of foot conditions, the risk of foot ulceration and its associated factors in patients with diabetes. Few studies have focused on the risk of foot ulceration in patients with diabetes.MethodsA total of 267 patients with diabetes who attended outpatient clinics in two tertiary referral hospitals were recruited from June to September 2016. The risk of foot ulceration was classified using the American Diabetes Association (ADA), International Working Group on the Diabetic Foot (IWGDF) and Scottish Intercollegiate Guidelines Network (SIGN) classification systems. The risk categories of each system were reclassified into high‐ (categories of 2 and 3 for the ADA and IWGDF systems and high for the SIGN system) and low‐risk.ResultsFoot deformity was the most prevalent condition (38.2%). Among 261 patients without active ulcers, between 17.6% to 35.2% were classified in the high‐risk group and overall agreement among systems ranged from .42 to .56 of the kappa statistic. Insulin treatment was consistently associated with a high‐risk of foot ulceration.ConclusionsAs the risk varies between systems, nurses should select a suitable classification system through validation studies and assess the risk in patients with diabetes, particularly, those receiving insulin treatment.
A theoretical model of cross‐cultural impression management in employment interviews
Authors: Arseneault Rene , Roulin Nicolas 
Published: September 2021

AbstractWith organizations being increasingly multinational and multicultural, there is a need for understanding the implications of having job applicants and interviewers from various cultural backgrounds interacting in an employment interview. We propose a theoretical model for understanding how cultural values translate into preferences for, and use of, impression management (IM) tactics in employment interviews. Building upon previous cross‐cultural IM models and relying on GLOBE cultural framework, we suggest that various cultural dimensions are associated with subsequent differences in applicants' use of both honest and deceptive forms of self‐focused, other‐focused, and defensive IM tactics in interviews. Our model also predicts that cultural distance, and indirectly difference between applicant IM use and interviewers' expectations, will determine how interviewers evaluate applicant interview performance. We highlight the importance of organizations taking responsibility in developing culturally conscientious selection methods to avoid potentially biased hiring decisions.
Influence of aging on periodontal regenerative therapy using enamel matrix derivative: A 3‐year prospective cohort study
Authors: Mikami Risako , Mizutani Koji , Shioyama Hidehiro , Matsuura Takanori , Aoyama Norio , Suda Tomonari , Kusunoki Yukako , Takeda Kohei , Izumi Yuichi , Aida Jun , Aoki Akira , Iwata Takanori 
Published: September 2021

AbstractAimTo investigate the influence of chronological aging on periodontal regenerative therapy (PRT) outcomes with enamel matrix derivative (EMD).Materials and MethodsIn total, 253 intra‐bony defects (151 patients) including 44 furcation involvement were prospectively investigated for 3 years after regenerative therapy with EMD by evaluating probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone defect depth (RBD). The influence of age on these outcomes was assessed using multilevel regression analyses adjusting for confounders.ResultsParticipants' mean age was 55.9 ± 12.3 years (range: 22–85). Baseline PPD, CAL, and RBD were 6.14 ± 1.82, 7.22 ± 2.14, and 5.08 ± 2.04 mm, respectively. Significant improvement was observed with PPD reductions of 2.84 ± 1.73 and 2.87 ± 1.87 mm, CAL gains of 2.40 ± 1.87 and 2.47 ± 1.89 mm, and RBD gains of 1.76 ± 1.98 and 2.39 ± 2.41 mm at 1‐ and 3‐year examinations, respectively. At the 1‐year examination, multivariate analysis revealed a significant negative association between age and improvement in PPD and CAL (coefficients: −0.13, −0.23 mm per 10 years). However, by the 3‐year examination, no significant association was noted between age and improvement in PPD, CAL, or RBD.ConclusionAlthough the statistical difference was detected with age at 1‐year examination, PRT with EMD significantly improved clinical outcomes on long‐term observation, irrespective of the patient's age.Clinical trial registration numberUMIN000039846.
Are the chilblain‐like lesions observed during the COVID‐19 pandemic due to severe acute respiratory syndrome coronavirus 2? Systematic review and meta‐analysis
Authors: Sánchez‐García V. , Hernández‐Quiles R. , de‐Miguel‐Balsa E. , Docampo‐Simón A. , Belinchón‐Romero I. , Ramos‐Rincón J.M. 
Published: September 2021

AbstractThe expansion of the COVID‐19 pandemic has been accompanied by numerous reports of chilblain‐like lesions (CLL) in different countries; however, the pathogenesis of these lesions is still unclear. This systematic review and meta‐analysis aimed to assess the prevalence of COVID‐19 (diagnosed using PCR and/or serology) in patients with CLL. We undertook a literature search in PubMed, Embase, and Scopus (to 15 March 2021), including studies that reported on the number of patients with CLL with positive PCR and/or serology for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) or with a clinical suspicion of COVID‐19. Regardless of data heterogeneity, a random‐effects model was used to pool prevalence estimates. The meta‐analysis included 63 original studies, involving 2919 cases of CLL. A subgroup of these patients underwent diagnostic tests for COVID‐19 (PCR: n = 1154, 39.5%; serology: n = 943, 32.3%). The pooled prevalence of COVID‐19 in the overall sample and in the subgroup who were tested for COVID‐19 was, respectively: (i) positive PCR: 2.6% [95% confidence interval (CI) 1.9% to 3.4%] and 5.5% (95% CI, 3.7–7.7%); (ii) positive serology for SARS‐CoV‐2: 7.2% (95% CI, 4.7–10.2%) and 11.8% (95% CI, 7.9–16.3%); and (iii) positive PCR and/or serology, 15.2% (95% CI, 10.4–20.7%) and 7.5% (95% CI, 5.1–10.3%). Altogether, a small proportion of diagnostic tests for SARS‐CoV‐2, both PCR and serologies, show positive results in patients with CLL.
Does female resistance to mating select for live‐fast‐die‐young strategies in males? A comparative analysis in the genus Drosophila
Authors: Macartney Erin L. , Bonduriansky Russell 
Published: September 2021

AbstractFemale promiscuity is a pervasive selective force on male reproductive traits, and the strength of sexual selection is predicted to influence the trade‐off between lifespan and reproduction. In species where sexual selection is intense, males are predicted to invest in sexual strategies that shorten their lifespan, potentially resulting in female‐biased sexual dimorphism in longevity. However, comparative analyses have provided contrasting results, potentially due to the use of broad mating system categories or sexual size dimorphism as a proxy for sexual selection. Here, we used female remating rate (i.e. female promiscuity) as a more direct measure of sexual selection strength and conducted a phylogenetic comparative analysis of the relationship between female remating rate and sexual dimorphism in lifespan in 29 species of Drosophila. We did not find strong evidence that female remating rate was correlated with sexual dimorphism in lifespan. However, we found that male and female lifespans are positively correlated among species and that phylogeny and residual variance (i.e. variation in non‐phylogenetic factors) are important in determining female remating rate, male and female lifespans separately, and the correlation between male and female lifespan. We suggest that variation in the nature of sexual competition and variation between studies could account for some of the unexplained variation among species in the relation between female remating rate and sexual dimorphism in lifespan.
Identifying consumer segments based on COVID‐19 pandemic perceptions and responses
Authors: Sheng Xiaojing , Ketron Seth C. , Wan Yubing 
Published: September 2021

AbstractConsumer responses to the COVID‐19 pandemic have varied widely. Thus, marketers need to understand consumer segments based on pandemic‐related responses and behaviors. Through two studies conducted 9 months apart, we find that consumers shift from three segments in Study 1—the Apprehensive, the Prepared, and the Dismissive, to two segments in Study 2—the Dedicated and the Dismissive. The Apprehensive feel particularly threatened of the virus. The Prepared and the Dedicated perceive a lower susceptibility but still take the health threat seriously. The Dismissive downplay the threat and exhibit more negative reactions to mitigation measures. We also demonstrate between‐segment downstream response differences. While the Apprehensive and the Prepared/Dedicated exhibit positive attitude toward companies enforcing guidelines, the Apprehensive engage in the most panic buying, hoarding, and stockpiling. The Dedicated also express greater stress and less life satisfaction than the Dismissive. The findings offer theoretical and practical implications for pandemic‐related consumer responses.
Asset Pricing and Sports Betting
Authors: MOSKOWITZ TOBIAS J. 
Published: September 2021

ABSTRACTSports betting markets offer a novel laboratory to test theories of cross‐sectional asset pricing anomalies. Two features of this market—no systematic risk and terminal values exogenous to betting activity—evade the joint hypothesis problem, allowing mispricing to be detected. Examining a large and diverse set of liquid betting contracts, I find strong evidence of momentum, consistent with delayed overreaction and inconsistent with underreaction and rational pricing. Returns are a fraction of those in financial markets and fail to overcome transactions costs, preventing arbitrage from eliminating them. An insight from betting also predicts value and momentum returns in U.S. equities.
Are pregnancy and postpartum oxytocin level a predictive biomarker for postpartum depression?
Authors: Cevik Ayseren , Alan Sultan 
Published: September 2021

AbstractAimThis study aims to determine the relationship between the late pregnancy and postpartum oxytocin levels and postpartum depression (PPD) symptoms.MethodsThis longitudinal study was conducted with 70 pregnant women. Data collection was performed through two interviews. While the first interview was conducted in the 30th to 38th gestational weeks, the second interview was conducted in the 4th to 12th weeks in the postpartum period. Oxytocin level measurement was performed with a saliva sample. Saliva samples were analyzed with enzyme‐linked immunosorbent assay kits.ResultsThe prevalence of depressive symptoms in the postpartum period was found significantly higher than the prevalence in late pregnancy. Depression symptoms reached the highest level in the 12th week. The late pregnancy oxytocin level was significantly higher than the postpartum oxytocin level. A weak, negative correlation was found between PPD symptoms and the late pregnancy oxytocin level. However, when linear regression analysis was performed, it was concluded that there was a medium, negative relationship model between PPD symptoms and the late pregnancy oxytocin level. However, no relationships were found between PPD symptoms and oxytocin level.ConclusionIn conclusion, this study found that the late pregnancy oxytocin level could be a predictive biomarker for postpartum depression. Predicting the risk of PPD in the pregnancy period could provide an opportunity for early diagnosis and treatment.
Variations of digestive enzymatic activity of the longarm river prawn, Macrobrachium tenellum (Smith 1871) adapted from the wild to culture with prepared meals
Authors: De los Santos Romero Rodolfo , Álvarez‐González Alfonso , Peña‐Marín Emyr , Jacinto Edilmar Cortes , Hernández Luis Héctor , García‐Guerrero Marcelo 
Published: September 2021

AbstractMacrobrachium tenellum is an omnivorous freshwater prawn living in rivers near the coast and in coastal lagoons with potential to be cultured. It is distributed in rivers, estuaries, and coastal lagoons, and in each of those habitats, it has access to food items with different features and nutritional content. In this research, it has been tested if this variety of food availability has an immediate effect on their digestive enzymatic activity once animals are brought to laboratory and fed with different meals. Wild prawns were captured in a river and coastal lagoon, and after acclimation, they were fed with three different experimental diets. Total alkaline protease, trypsin, chymotrypsin, lipase, and α amylase were measured from prawns fed experimental diets at 15 and 30 days. There were significant differences in the enzymatic activity of prawns depending on their original habitat and diet. However, the proportion in which these enzymes are expressed in the prawns from different treatments remains proportional to what was observed in wild specimens, as reported in previous research. We consider that the study of this phenomenon can contribute to a better understanding of the nutritional needs of this species if a species‐specific diet needs to be prepared.
Development and regeneration of wheat–rice hybrid zygotes produced by in vitro fertilization system
Authors: Maryenti Tety , Ishii Takayoshi , Okamoto Takashi 
Published: September 2021

Summary

Hybridization plays a decisive role in the evolution and diversification of angiosperms. However, the mechanisms of wide hybridization remain open because pre‐ and post‐fertilization barriers limit the production and development of inter‐subfamily/intergeneric zygotes, respectively.

We examined hybridization between wheat and rice using an in vitro fertilization (IVF) system to bypass these barriers. Several gamete combinations of allopolyploid wheat–rice hybrid zygotes were successfully produced, and the developmental profiles of hybrid zygotes were analyzed.

Hybrid zygotes derived from one rice egg cell and one wheat sperm cell ceased at the multicellular embryo‐like structure stage. This developmental barrier was overcome by adding one wheat egg cell to the wheat–rice hybrid zygote. In the reciprocal combination, one wheat egg and one rice sperm cell, the resulting hybrid zygotes failed to divide. However, doubling the dosage of rice sperm cell allowed the hybrid zygotes to develop into plantlets. Rice chromosomes appeared to be progressively eliminated during the early developmental stage of these hybrid embryos, and c. 20% of regenerated plants showed abnormal morphology.

These results suggest that hybrid breakdown can be overcome through optimization of gamete combinations, and the present hybrid will provide a new horizon for utilization of inter‐subfamily genetic resources.