bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bio‐mimicked guided tissue regeneration/guided bone regeneration membranes with hierarchical structured surfaces replicated from teak leaf exhibits enhanced bioactivity
Authors: Satpathy Anurag , Mohanty Rinkee , Rautray Tapash R. 
Published: July 2021

AbstractBio‐mimicked GTR/GBR membranes with hierarchical structured surfaces were developed by direct and indirect replication of teak leaf surface. The membranes were fabricated using solvent casting method with customized templates. The surfaces obtained were those with micro‐trichomes (MTS) and micro‐depression (MDS) that resembled a whorling pattern. Structural details of the fabricated membrane surfaces were studied under stereomicroscope and scanning electron microscopy. Surface roughness, water wetting angle, water uptake, and degradation properties of the membranes were examined. The effects of the micro‐patterned hierarchical structure on in vitro bioactivities of human osteoblast‐like cells (MG63) and human gingival fibroblast cells HGF1‐RT1 were studied. In vivo study carried out on rat skulls to assess the response of surrounding tissues for 4 weeks showed that the bio‐mimicked MTS and MDS membrane surfaces enhanced the cell proliferation. The proliferation significantly increased with increasing surface roughness and decreasing contact angle. There was also an evidence of rapid new bone maturation with membranes with MTS. It is thus suggested that the teak leaf mimicked whorling patterned hierarchical structured surface is an important design for enhancing bioactivity.
A novel water‐dispersible and magnetically recyclable nickel nanoparticles for the one‐pot reduction‐Schiff base condensation of nitroarenes in pure water
Authors: Ghamari Kargar Pouya , Ravanjamjah Asiye , Bagherzade Ghodsieh 
Published: July 2021

AbstractIn this work, a heterogeneous nanocatalyst called Ni‐Fe3O4@Pectin~PPA ~ Piconal was first synthesized, which was investigated as a bifunctional catalyst containing nickel functional groups. On the other hand, this Ni‐Fe3O4@Pectin~PPA ~ Piconal catalyst in aqueous solvents shows a very effective performance at ambient temperature for the nitroarene reduction reaction with sodium borohydride, for which NaBH4 is considered as a reducing agent. This is a novelty magnetic catalyst that was approved by various methods, including Fourier‐transform infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD), Dynamic light scattering (DLS), Transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), Inductively coupled plasma (ICP), Energy‐dispersive X‐ray spectroscopy (EDX), and Field emission scanning electron microscopy (FESEM) analyses. From the satisfactory results obtained from the reduction of nitrogen, this catalytic system is used for a one‐pot protocol containing a reduction‐Schiff base concentration of diverse nitroarenes. It was corroborated with the heterogeneous catalytic experiments on the one‐pot tandem synthesis of imines from nitroarenes and aldehydes. Finally, the novel Ni‐Fe3O4@Pectin~PPA ~ Piconal catalyst could function as a more economically desirable and environmentally amicable in the catalysis field. The favorable products are acquired in good to high performance in the attendance of Ni‐Fe3O4@Pectin~PPA ~ Piconal as a bifunctional catalyst. This catalyst can be recycled up to six steps without losing a sharp drop.
Recognizing the funds of knowledge of first‐generation college students in engineering: An instrument development
Authors: Verdín Dina , Smith Jessica M. , Lucena Juan C. 
Published: July 2021

AbstractBackgroundStudents who are the first in their families to attend college are an integral part of undergraduate engineering programs. Growing bodies of research argue that educators could better support these students if they understood the unique backgrounds, experiences, and knowledge they bring with them to higher education.Purpose/HypothesisThe purpose of this article is twofold. First, we identify salient funds of knowledge used by a group of first‐generation college students in their educational and work‐related experiences. Secondly, we use the funds of knowledge identified in our participants' experiences to create a survey instrument.Design/MethodA mixed methods approach was used. Ethnographic interview data of six first‐generation college students were used to hypothesize constructs and create survey items. Survey data were collected from 812 students. Exploratory and confirmatory factor analyses were used to verify the underlying theoretical structures among the survey items and hypothesized constructs.ResultsValidity evidence supported a 10‐factor model as opposed to the hypothesized 6‐factor model. The 10 latent constructs that make up the funds of knowledge instrument are as follows: tinkering knowledge from home, tinkering knowledge from work, connecting experiences, networks from family members, networks from college friends, networks from coworkers, networks from neighborhood friends, perspective taking, reading people, and mediating ability.ConclusionsRecognizing first‐generation college students' funds of knowledge is a first step to creating curricular spaces and experiences that better serve them. A survey scale allows educators to empirically examine how these accumulated bodies of knowledge are transmitted to capital, create advantages in engineering, and provides a useful tool to bridge students' knowledge in the classroom.
Too much self‐promotion! How self‐promotion climate relates to employees' supervisor‐focused self‐promotion effectiveness and their work group's performance
Authors: Gross Christian , Debus Maike E. , Ingold Pia V. , Kleinmann Martin 
Published: July 2021

SummarySelf‐promotion has largely been researched from an individual perspective. It is thus unclear if this behavior is functional or dysfunctional within a broader social context. The present study offers a contribution in this regard by examining self‐promotion within work groups. In particular, we hypothesized that work group self‐promotion climate—referring to the shared perception of the occurrence of self‐promotion in the work group—moderates the relationships between individuals' supervisor‐focused self‐promotion and supervisor ratings of both job performance and promotability. More precisely, we expected these relationships to be positive only when self‐promotion climate is low. With respect to the entire work group, we further hypothesized that self‐promotion climate negatively relates to supervisor‐rated work group performance via impaired work group cohesion. We tested these propositions with data from 195 work groups. Multivariate path analysis provided support for our hypothesized model. Taken together, our findings illustrate the important role of self‐promotion as a climate construct. In particular, self‐promotion climate helps us better understand the role of self‐promotion for individuals and work groups.
Swallowing Outcomes Following Supraglottoplasty: A Retrospective Review
Authors: Nguyen Mai , Brooks Laura , Wetzel Martha , Raol Nikhila 
Published: July 2021

Objectives/HypothesisDetermine the incidence of short‐ and long‐term dysphagia in pediatric patients with and without syndromes/neurodevelopmental delay following supraglottoplasty (SGP) at our institution.Study DesignRetrospective cohort study.MethodsA retrospective cohort study of children ≤18 years old who underwent SGP from 2014 to 2019 was undertaken. Age at surgery, sex, race, insurance, underlying syndromes/neurodevelopmental delay, concurrent surgical procedures, and clinical swallowing assessments were reviewed. Logistic regression was performed to identify factors associated with postoperative feeding difficulties. Time‐to‐event analysis was performed to assess time to resolution of dysphagia.ResultsA total of 231 patients were identified. Average age at time of SGP was 13.7 months. Of 231 patients, 88 (38.1%) had a syndrome/neurodevelopmental delay. Of these 231 patients, 112 had a preoperative videofluoroscopic swallow study or fiberoptic endoscopic evaluation of swallowing, of whom 53/112 (47.3%) had dysphagia. After SGP, 138/231 (59.7%) underwent clinical/instrumental swallowing assessments, of whom 95/138 (68.8%) had immediate postsurgical dysphagia. At last follow‐up (1 month to 45 months), 15/95 (15.8%) had persistent dysphagia on instrumental assessment, 14/15 of whom had syndromes/neurodevelopmental delay. Time‐to‐event analysis revealed that for the nonsyndromic cohort, 25% had resolution of dysphagia by 4 months, 50% by 10 months, and 75% by 14 months. Cox proportional hazards regression revealed that the presence of underlying syndromes/neurodevelopmental delay was the only factor predictive of long‐term postoperative dysphagia (hazard ratio of resolution 0.21 [95% confidence interval 0.096–0.48]).ConclusionsWhile short‐term feeding difficulties following SGP in pediatric patients are not uncommon, long‐term dysphagia is rare in patients without syndromes/neurodevelopmental delay. These data can be used when counseling caregivers about the risks and benefits of SGP.Level of Evidence4 Laryngoscope, 131:2817–2822, 2021
A centrosymmetric‐coupled tri‐band bandpass filter constituted by loaded bar and embedded S‐shaped resonator
Authors: Ding Shu‐Cong , Liang Jun‐Ge , Wang Xiao , Wang Cong , Kim Nam‐Young , Gu Xiaofeng 
Published: July 2021

AbstractIn this study, a novel tri‐band bandpass filter supported by five resonant modes is developed on the basis of two coupled open‐loop resonators with center‐loaded bars (CLBs). Embedding the S‐shaped resonator into the open‐loop structure generates a new passband while keeping the same layout area. Also, another LB located between the open‐loop resonator and the CLB is introduced to provide the perturbation for generating new resonances. The final design is realized by the structure optimization via adjusting the coupling coefficients and external quality factors. The measurements match well with the simulation which proves its practicability in (0.45–6 GHz) 5G frequency range‐1 (FR‐1).
A systematic review of binge eating, loss of control eating, and weight loss in children and adolescents
Authors: Moustafa Afaf F. , Quigley Kerry M. , Wadden Thomas A. , Berkowitz Robert I. , Chao Ariana M. 
Published: July 2021

AbstractObjectiveThis review synthesizes literature on changes in binge eating (BE) and loss of control eating (LOC) following weight loss and the association between BE/LOC and weight loss in children and adolescents.MethodsA systematic literature search was conducted in PubMed, Scopus, and PsycInfo. Eligible studies included all peer‐reviewed journal articles of primary research that assessed BE/LOC and weight change following a weight‐loss intervention in individuals under 18 years of age.ResultsThe 29 articles included studies on behavioral therapy, pharmacotherapy, and surgical interventions. Of the 14 studies that assessed the relationship between weight loss and BE/LOC at baseline, 4 showed that higher baseline BE/LOC was associated with less weight loss, whereas 10 showed no significant association. BE/LOC behaviors significantly decreased following weight‐loss interventions in 20 of 21 studies. A greater decrease in BE/LOC was associated with improved weight loss in 4 of 9 studies that assessed this change.ConclusionsWeight‐loss interventions are associated with improved BE/LOC in youth with obesity. The persistence of BE/LOC symptoms may be associated with less weight loss. These results can aid in guiding future treatment for youth with BE/LOC seeking weight‐loss treatment.
Ibritumomab Tiuxetan Radioimmunotherapy for Primary Gastrointestinal Follicular Lymphoma
Authors: Desai Sanjal , Moustafa Muhamad Alhaj , Wiseman Gregory , Witzig Thomas 
Published: July 2021

AbstractPrimary gastrointestinal follicular lymphoma (PGIFL) is characterized by localized involvement of the gastrointestinal (GI) tract. PGIFL usually runs an indolent course. External beam radiation therapy is curative in a substantial proportion of localized follicular lymphomas, but GI toxicities may discourage its use in PGIFL. Ibritumomab tiuxetan radioimmunotherapy (RIT) is a radioimmunoconjugate of anti-CD20 monoclonal antibody linked to chelator tiuxetan and radioisotope. RIT delivers confined high-intensity radiation with short path length specifically targeting lymphoma cells and sparing normal tissue. In this case series report, we included six cases of PGIFL treated with RIT. All patients had low-risk, localized, and nonbulky disease. All patients responded completely and were relapse-free for the duration of follow-up. Hematologic toxicities were seen, but none were serious. RIT is a potentially curative treatment option in PGIFL with a tolerable toxicity profile.
BRAF Inhibitor Therapy-Related Encephalitis in a Patient with Metastatic Melanoma
Authors: Babacan Nalan Akgul , Peguero Edwin , Forsyth Peter , Eroglu Zeynep 
Published: July 2021

Abstract

Introduction
BRAF inhibitors such as encorafenib and vemurafenib in combination with MEK inhibitors are commonly used for the treatment of patients with BRAF V600–mutant melanoma.

Case Presentation
A patient with relapsed metastatic melanoma with a BRAF V600 mutation was started on treatment with vemurafenib and cobimetinib. Within 2 weeks of treatment start, he was hospitalized and diagnosed with encephalitis through a lumbar puncture and treated with corticosteroids, with subsequent normalization of cerebrospinal fluid (CSF) findings. When he recovered and was switched to encorafenib treatment, the same symptoms recurred, and the patient was treated with high-dose steroids and intravenous immunoglobulin, again with improvement in his CSF. He has not had a relapse of his symptoms since BRAF inhibitor treatment was permanently discontinued.

Conclusion
This is the first known report of a patient who has developed encephalitis because of treatment with BRAF inhibitors.
Retrospective Study of Bleeding Risk with Concomitant Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor and Anticoagulation
Authors: Sivakumar Akhilesh , Caulfield Sarah E. , Zhang Chao , Goyal Subir , Bilen Mehmet A. , Beardslee Tyler J. 
Published: July 2021

AbstractBackgroundPatients with cancer are at higher risk for venous thromboembolism (VTE) and bleeding, in turn complicating anticoagulant therapy. An added complexity is the toxicity profile of agents used to treat certain cancers, namely the vascular endothelial growth factor receptor tyrosine kinase inhibitors (TKIs), which are associated with both thromboembolism and hemorrhages. The purpose of this study was to evaluate whether patients taking concurrent VEGF TKI and therapeutic anticoagulant were at higher risk for bleeding compared with patients taking VEGF TKI alone.Materials and MethodsThis was a single-center, retrospective chart review of patients who underwent treatment with a VEGF TKI with or without anticoagulant. The primary outcome included comparison of major bleeding rates between groups. Secondary outcomes included comparison of composite major and minor bleed rates and assessment of VTE incidence and recurrence among patients treated with a VEGF TKI and VEGF TKI plus anticoagulant, respectively.ResultsA total of 184 and 74 patients were included in the VEGF TKI alone and VEGF TKI + anticoagulant groups, respectively. Major bleeding events occurred in 6 of 184 patients (3.3%) and 6 of 74 patients (8.1%), respectively (p = .095). Composite major and minor bleeding events occurred in 22 of 184 (13.6%) and 17 of 74 (23%), respectively (p = .026). A total of 26 of 258 patients (10.1%) experienced a VTE event while taking a VEGF TKI, and 1 of 26 (3.8%) experienced a recurrent VTE event while taking a VEGF TKI plus anticoagulant.ConclusionPatients who received concomitant VEGF TKI plus anticoagulant had increased incidence of bleeding, although prospective studies are needed to further explore this association.Implications for PracticeThe current study showed that use of concomitant vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGF TKI) and therapeutic anticoagulation was associated with an increased risk of composite bleeding events, although at comparable rates between patients treated with VEGF TKI plus direct oral anticoagulant (DOAC) versus VEGF TKI plus non-DOAC anticoagulant. This suggests that when anticoagulation is indicated in a patient receiving a VEGF TKI, the novel DOACs may be a safe alternative to historical anticoagulants (warfarin and enoxaparin). These results fill a gap in the literature and will help guide treatment decisions for patients requiring concurrent VEGF TKI and anticoagulation.
Biodegradable cross‐linked poly(1,3‐trimethylene carbonate) networks formed by gamma irradiation under vacuum
Authors: Liu Xiliang , Liu Song , Feng Shaomin , Li Kaiqi , Fan Youkun , Wang Xin , Xiao Jianping , Bai Wei , Chen Dongliang , Xiong Chengdong , Zhang Lifang 
Published: July 2021

AbstractRubbery biodegradable cross‐linked poly (1,3‐trimethylene carbonate) (PTMC) networks were prepared by gamma irradiation under vacuum in the presence of trimethylolpropane triacrylate (TMPTA), pentaerythritol triacrylate (PETA), and pentaerythritol tetraacrylate (PET4A). The effect of crosslinking agent, crosslinking agent content (1, 3, 5, 7 wt%), and irradiation dose (25, 50, 75, 100, 125 kGy) on PTMC networks were evaluated. The crosslinking efficiency of PETA was better than that of TMPTA and PET4A at a standard sterilization dose of 25 kGy. The PTMC network with gel fractions up to 92% ± 1% and tensile strength up to 26.0 ± 2.2 MPa could be obtained by adding 7 wt% PETA. The increase in irradiation dose reduced the gel content and network density, and led to a decrease in mechanical properties. The PTMC network extracted by ethanol showed better flexibility and mechanical properties. The irradiation crosslinking of PTMC with 7 wt% PETA followed the Chen–Liu–Tang equation instead of the Charlesby–Pinner equation. The incorporation of crosslinking agents improved the creep resistance and thermal stability, resulting in low permanent set values (5.5%). Furthermore, the enzymatic erosion rates of the networks decreased. Therefore, these PTMC networks can be utilized in a broad range of soft tissue engineering.
Periostin deficiency reduces diethylnitrosamine‐induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation
Authors: Xiao Hongjun , Zhang Yezhen , Li Zhaofeng , Liu Bin , Cui Dan , Liu Fan , Chen Dafan , Liu Yingfu , Ouyang Gaoliang 
Published: July 2021

AbstractPeriostin is a critical extracellular regulator in the pathogenesis of liver disorders such as hepatosteatosis, non‐alcoholic steatohepatitis, inflammation, and fibrosis. Periostin is also involved in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms of periostin in hepatic stellate cell (HSC) activation and tumor cell proliferation in the pathogenesis of HCC remain largely unknown. We demonstrate that periostin is markedly upregulated in diethylnitrosamine (DEN)‐induced mouse HCC tissues and that periostin knockout impairs DEN‐induced HCC development. Periostin is predominantly derived from activated HSCs and periostin deficiency in HSCs impairs HSC activation and inhibits HSC‐promoted HCC cell proliferation in vitro and tumor growth in vivo. Mechanistically, periostin promotes HSC activation through the integrin–FAK–STAT3–periostin pathway and augments HCC cell proliferation by activating ERK. There are positive correlations between periostin and HSC activation and cell proliferation in HCC clinical samples. Collectively, our findings demonstrate that HSC‐derived periostin promotes HCC development by enhancing HSC activation through an autocrine periostin–integrin–FAK–STAT3–periostin circuit and by augmenting HCC cell proliferation via the ERK pathway in a paracrine manner. Thus, periostin is a multifaceted extracellular regulator in the development of HCC. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Late adverse effects of childhood acute lymphoblastic leukemia treatment on developing dentition
Authors: Immonen Egle , Nikkilä Atte , Peltomäki Timo , Aine Liisa , Lohi Olli 
Published: July 2021

AbstractBackgroundChildhood cancer survivors show a variety of late adverse effects on dental health. The purpose of this study was to examine the prevalence and severity of dental abnormalities in permanent dentition in childhood leukemia survivors.Materials and methodsRetrospective analysis of panoramic radiographs was performed for 178 childhood leukemia survivors aged below 17 years at the time of diagnosis. Sex, age at diagnosis, interval between ALL diagnosis and the follow‐up radiograph, treatment protocol, and risk grouping were recorded. Abnormalities of tooth development and defect index were used to assess the frequency and severity of dental abnormalities.ResultsOne hundred eight (61%) patients had no dental abnormalities at follow‐up examination at a median of 6.1 years after diagnosis. Microdontia was more frequent in children under 6 years of age at the time of diagnosis (5.7% vs. 0.6%, p < .001). Significant differences were noted between distinct ALL treatment protocols with more common microdontia in patients treated according to the NOPHO ALL2008 protocol. Tooth agenesis was more frequent in patients that underwent therapy according to high‐risk arms compared to intermediate‐ or standard‐risk arms (3.8% vs. 1.4%, p = .01). Patients under 6 years of age at diagnosis had a significantly higher average defect index score than older patients (7.0 vs. 2.8, p = .01).ConclusionsChildren and adolescents who received ALL treatment were at risk for dental damage. Young age and high‐intensity therapy were associated with the severity of dental abnormalities.
Mechanical behavior of carboxylic functionalized graphene reinforced polyurethane nanocomposites under static and dynamic loading
Authors: Dhawan Aakash , Jindal Prashant 
Published: July 2021

AbstractThe present work reports formation of polyurethane (PUR) and carboxylic functionalized graphene (COOH‐fG) nanocomposites via solution mixing method and static and dynamic mechanical characterization with dynamic mechanical analysis (DMA), nano indentation, and tensile and compressive testing. Magnetic stirring of the solutions of PUR in N,N dimethylformamide (DMF) and COOH‐fG in DMF was performed for different compositions of filler, 1%, 3%, 5%, 7%, and 10%, which were heated to obtain nanocomposite films followed by injection molding to cast into samples. Uniform dispersion and good intercalation were observed upon characterization by field emission scanning electron microscopy and X‐ray diffraction techniques. DMA showed that the storage modulus improved with increasing frequency of loading, and a linear decrement in the damping factor with an increase in the concentration of filler was observed. The maximum depth of indent in nano‐indentation test showed a decreasing trend, indicating improvement in nanohardness and elastic modulus with an optimum obtained at 5 wt% composition. An improvement in tensile modulus, tensile strength, and toughness, which were more substantial at lower compositions of filler, was observed. An optimum compressive modulus was obtained for 10 wt% of filler due to more resistance provided by graphene plates to compression as compared to PUR.