bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpregnancy intervals and child development at age 5: a population data linkage study
Authors: Dhamrait Gursimran Kaur , Taylor Catherine Louise , Pereira Gavin 
Published: March 2021

ObjectiveTo investigate the associations between interpregnancy intervals (IPIs) and developmental vulnerability in children’s first year of full-time school (age 5).DesignRetrospective cohort study using logistic regression. ORs were estimated for associations with IPIs with adjustment for child, parent and community sociodemographic variables.SettingWestern Australia (WA), 2002–2015.Participants34 574 WA born singletons with a 2009, 2012 or 2015 Australian Early Development Census (AEDC) record.Main outcome measureThe AEDC measures child development across five domains; Physical Health and Wellbeing, Social Competence, Emotional Maturity, Language and Cognitive Skills (school-based) and Communication Skills and General Knowledge. Children with scores <10th percentile were classified as developmentally vulnerable on, one or more domains (DV1), or two or more domains (DV2).Results22.8% and 11.5% of children were classified as DV1 and DV2, respectively. In the adjusted models (relative to the reference category, IPIs of 18–23 months), IPIs of <6 months were associated with an increased risk of children being classified as DV1 (adjusted OR (aOR) 1.17, 95% CI 1.08 to 1.34), DV2 (aOR 1.31, 95% CI 1.10 to 1.54) and an increased risk of developmental vulnerability for the domains of Physical Health and Wellbeing (aOR 1.25, 95% CI 1.06 to 1.48) and Emotional Maturity (aOR 1.36, 95% CI 1.12 to 1.66). All IPIs longer than the reference category were associated with and increased risk of children being classified as DV1 and DV2 (aOR >1.15). IPIs of 60–119 months and ≥120 months, were associated with an increased risk of developmental vulnerability on each of the five AEDC domains, with greater odds for each domain for the longer IPI category.ConclusionsIPIs showed independent J-shaped relationships with developmental vulnerability, with short (<6 months) and longer (≥24 months) associated with increased risks of developmental vulnerability.
Predictors of clinical deterioration in patients with suspected COVID-19 managed in a ‘virtual hospital’ setting: a cohort study
Authors: Francis Nick A , Stuart Beth , Knight Matthew , Vancheeswaran Rama , Oliver Charles , Willcox Merlin , Barlow Andrew , Moore Michael 
Published: March 2021

ObjectiveIdentify predictors of clinical deterioration in a virtual hospital (VH) setting for COVID-19.DesignReal-world prospective observational study.SettingVH remote assessment service in West Hertfordshire NHS Trust, UK.ParticipantsPatients with suspected COVID-19 illness enrolled directly from the community (postaccident and emergency (A&E) or medical intake assessment) or postinpatient admission.Main outcome measureDeath or (re-)admission to inpatient hospital care during VH follow-up and for 2 weeks post-VH discharge.Results900 patients with a clinical diagnosis of COVID-19 (455 referred from A&E or medical intake and 445 postinpatient) were included in the analysis. 76 (8.4%) of these experienced clinical deterioration (15 deaths in admitted patients, 3 deaths in patients not admitted and 58 additional inpatient admissions). Predictors of clinical deterioration were increase in age (OR 1.04 (95% CI 1.02 to 1.06) per year of age), history of cancer (OR 2.87 (95% CI 1.41 to 5.82)), history of mental health problems (OR 1.76 (95% CI 1.02 to 3.04)), severely impaired renal function (OR for eGFR <30=9.09 (95% CI 2.01 to 41.09)) and having a positive SARS-CoV-2 PCR result (OR 2.0 (95% CI 1.11 to 3.60)).ConclusionsThese predictors may help direct intensity of monitoring for patients with suspected or confirmed COVID-19 who are being remotely monitored by primary or secondary care services. Further research is needed to confirm our findings and identify the reasons for increased risk of clinical deterioration associated with cancer and mental health problems.
Patient safety culture improves during an in situ simulation intervention: a repeated cross-sectional intervention study at two hospital sites
Authors: Schram Anders , Paltved Charlotte , Christensen Karl Bang , Kjaergaard-Andersen Gunhild , Jensen Hanne Irene , Kristensen Solvejg 
Published: March 2021

ObjectivesThis study aimed to investigate staff’s perceptions of patient safety culture (PSC) in two Danish hospitals before and after an in situ simulation intervention.DesignA repeated cross-sectional intervention study.SettingTwo Danish hospitals. Hospital 1 performs emergency functions, whereas hospital 2 performs elective functions.ParticipantsA total of 967 healthcare professionals were invited to participate in this study. 516 were employed in hospital 1 and 451 in hospital 2. Of these, 39 were trained as simulation instructors.InterventionA 4-day simulation instructor course was applied. Emphasis was put on team training, communication and leadership. After the course, instructors performed simulation in the hospital environment. No systematic simulation was performed prior to the intervention.Main outcome measuresThe Safety Attitude Questionnaire investigating PSC was applied prior to the intervention and again 4 and 8 weeks after intervention. The proportion of participants with a positive attitude and mean scale scores were measured as main outcomes.ResultsThe response rate varied from 63.6% to 72.0% across surveys and hospitals. Baseline scores were generally lower for hospital 1. The proportion of staff with positive attitudes in hospital 1 improved by ≥5% in five of six safety culture dimensions, whereas only two dimensions improved by ≥5% in hospital 2. The mean scale scores improved significantly in five of six safety culture dimensions in hospital 1, while only one dimension improved significantly in hospital 2.ConclusionsSafety attitude outcomes indicate an improvement in PSC from before to after the in situ simulation intervention period. However, it is possible that an effect is more profound in an acute care hospital versus an elective setting.
Increased incidence and treatment of intracranial atherosclerotic disease during mechanical thrombectomy is safe, even with an increased number of passes
Authors: Monayao Marlon Carl , Malik Ahmed A , Preston Laurie , Monayao Sr Marlon Carl , Tekle Wondwossen , Hassan Ameer E 
Published: March 2021

BackgroundThe incidence of intracranial atherosclerotic disease (ICAD) in acute ischemic stroke treated with mechanical thrombectomy (MT) is not well defined, and its description may lead to improved stroke devices and rates of first pass success.MethodsA retrospective study was performed on MT patients from 2012 to 2019 at a comprehensive stroke center using chart review and angiogram analysis. Angiograms at the time of MT were reviewed for ICAD, and location and severity were recorded. Patients with ICAD were divided according to ICAD location relative to the large vessel occlusion (LVO) site. Statistical analyses were performed on baseline demographics, comorbidities, MT procedure variables, outcome variables, and their association with ICAD.ResultsOf the 533 patients (mean age 70.4 (SD 13.20) years, 43.5% women), 131 (24.6%) had ICAD. There was no significant difference in favorable discharge outcomes (modified Rankin Scale score of 0–2; 23.8% ICAD vs 27.0% non-ICAD; p=0.82) or groin puncture to recanalization times (average 43.5 (range 8–181) min for ICAD vs 40.2 (4–204) min for non-ICAD; p=0.42). Patients with ICAD experienced a significantly higher number of passes (average 1.8 (range 1–7) passes for ICAD vs 1.6 (1–5) passes for non-ICAD; p=0.0059). Adjusting for age, ≥3 device passes, baseline National Institutes of Health Stroke Scale, rates of angioplasty only, rates of concurrent angioplasty and stenting, coronary artery disease and atrial fibrillation incidences, and time from emergency department arrival to recanalization, yielded no significant difference in rates of favorable outcomes between the two groups.ConclusionPatients who underwent MT with underlying ICAD had similar rates of favorable outcomes as those without, but required a higher number of device passes.
Temperature variability and asthma hospitalisation in Brazil, 2000–2015: a nationwide case-crossover study
Authors: Wu Yao , Xu Rongbin , Wen Bo , Coelho Micheline de Sousa Zanotti Staglior , Saldiva Paulo H , Li Shanshan , Guo Yuming 
Published: March 2021

BackgroundBoth cold and hot temperature have been associated with the onset of asthma, but it remains largely unknown about the risk of asthma hospitalisation associated with short-term temperature fluctuation or temperature variability (TV).ObjectiveTo explore the association between short-term exposure to TV and asthma hospitalisation in Brazil.MethodsData for asthma hospitalisation and weather conditions were collected from 1816 Brazilian cities between 2000 and 2015. TV was calculated as the SD of all daily minimum and maximum temperatures within 0–7 days prior to current day. A time-stratified case-crossover design was performed to quantify the association between TV and hospitalisation for asthma.ResultsA total of 2 818 911 hospitalisations for asthma were identified during the study period. Each 1°C increase in 0–7 days’ TV exposure was related to a 1.0% (95% CI 0.7% to 1.4%) increase in asthma hospitalisations. The elderly were more vulnerable to TV than other age groups, while region and season appeared to significantly modify the associations. There were 159 305 (95% CI 55 293 to 2 58 054) hospitalisations, US$48.41 million (95% CI US$16.92 to US$78.30 million) inpatient costs at 2015 price and 450.44 thousand inpatient days (95% CI 156.08 to 729.91 thousand days) associated with TV during the study period. The fraction of asthma hospitalisations attributable to TV increased from 5.32% in 2000 to 5.88% in 2015.ConclusionTV was significantly associated with asthma hospitalisation and the corresponding substantial health costs in Brazil. Our findings suggest that preventive measures of asthma should take TV into account.
Post-traumatic stress disorder can be predicted in hospitalized blunt trauma patients using a simple screening tool
Authors: Rahmat Saad , Velez Jessica , Farooqi Muhammad , Smiley Abbas , Prabhakaran Kartik , Rhee Peter , Khan Maria , Dornbush Rhea , Ferrando Stephen , Smolin Yvette 
Published: March 2021

BackgroundPost-traumatic stress disorder (PTSD) has debilitating psychiatric and medical consequences. The purpose of this study was to identify whether PTSD diagnosis and PTSD symptom scale score (PTSD severity) could be predicted by assessing peritraumatic experiences using a single question or screening tools at different time points in patients hospitalized after admission to the hospital after significant physical trauma, but with stable vitals (level II trauma).MethodsPatients completed the ‘initial question’ and the National Stressful Events Survey Acute Stress Disorder Scale (NSESSS) at 3 days to 5 days after trauma (NSESSS-1). The same scale was administered 2 weeks to 4 weeks after trauma (NSESSS-2). The Posttraumatic Stress Disorder Symptoms Scale Interview for DSM-5 (PSSI-5) was administered 2 months after trauma. PTSD diagnosis and PTSD severity were extracted from the PSSI-5. Linear multivariate regression analyses were used to establish whether scores for NSESSS-1 or NSESSS-2 predicted PTSD diagnosis/PTSD severity. Non-linear multivariate regression analyses were performed to better understand the relationship between NSESSS-1/NSESSS-2 and PTSD diagnosis/PTSD severity.ResultsA single question assessing the experience of fear, helplessness, or horror was not an effective tool for determining the diagnosis of PTSD (p=0.114) but can be a predictor of PTSD severity (p=0.039). We demonstrate that administering the NSESSS after either 3 days to 5 days (p=0.008, p<0.001) or 2 weeks to 4 weeks (p=0.039; p<0.001) can predict the diagnosis of PTSD and PTSD severity. Scoring an NSESSS above 14/28 (50%) increases the chance of experiencing a higher PTSD severity substantially and linearly.DiscussionOur initial question was not an effective predictor of PTSD diagnosis. However, using the NSESSS at both 3 days to 5 days and 2 weeks to 4 weeks after trauma is an effective method for predicting PTSD diagnosis and PTSD severity. Additionally, we show that patients who score higher than 14 on the NSESSS for acute stress symptoms may need closer follow-up.Level of evidenceLevel III, prognostic.
Single-cell motile behaviour of $${Trypanosoma\, brucei}$$ in thin-layered fluid collectives
Authors: Krüger Timothy , Maus Katharina , Kreß Verena , Meyer-Natus Elisabeth , Engstler Markus 
Published: March 2021

Abstract
We describe a system for the analysis of an important unicellular eukaryotic flagellate in a confining and crowded environment. The parasite Trypanosoma brucei is arguably one of the most versatile microswimmers known. It has unique properties as a single microswimmer and shows remarkable adaptations (not only in motility, but prominently so), to its environment during a complex developmental cycle involving two different hosts. Specific life cycle stages show fascinating collective behaviour, as millions of cells can be forced to move together in extreme confinement. Our goal is to examine such motile behaviour directly in the context of the relevant environments. Therefore, for the first time, we analyse the motility behaviour of trypanosomes directly in a widely used assay, which aims to evaluate the parasites behaviour in collectives, in response to as yet unknown parameters. In a step towards understanding whether, or what type of, swarming behaviour of trypanosomes exists, we customised the assay for quantitative tracking analysis of motile behaviour on the single-cell level. We show that the migration speed of cell groups does not directly depend on single-cell velocity and that the system remains to be simplified further, before hypotheses about collective motility can be advanced.

Graphic abstract
Investigating the Atomki anomaly in the framework of axial (ABJ) anomaly
Authors: Liu Chang-Yong 
Published: March 2021

An anomaly observed in the 8Be nuclear transition by the Atomki collaboration hints at a light, neutral boson decaying into an [Formula: see text] pair with a mass of about 17 MeV. In this paper, we study the Atomki anomaly in the framework of axial (ABJ) anomaly. Some theoretical results indicate that the X17 particle is the color singlet pseudoscalar. We take the X17 particle as a pseudoscalar meson [Formula: see text] system which has the axial (ABJ) anomaly, where [Formula: see text] denotes the up quark. Besides this, we also give an interpretation for E38 particle with a mass of about 38 MeV as a pseudoscalar meson [Formula: see text] system. We obtain the correct masses of the two pseudoscalars by a non-perturbative mass formula.
Information retrieval models for recommender systems
Authors: Valcarce Daniel 
Published: March 2021

Information retrieval addresses the information needs of users by delivering relevant pieces of information but requires users to convey their information needs explicitly. In contrast, recommender systems offer personalized suggestions of items automatically. Ultimately, both fields help users cope with information overload by providing them with relevant items of information.
This thesis aims to explore the connections between information retrieval and recommender systems. Our objective is to devise recommendation models inspired in information retrieval techniques. We begin by borrowing ideas from the information retrieval evaluation literature to analyze evaluation metrics in recommender systems [2]. Second, we study the applicability of pseudo-relevance feedback models to different recommendation tasks [1]. We investigate the conventional top-N recommendation task [5, 4, 6, 7], but we also explore the recently formulated user-item group formation problem [3] and propose a novel task based on the liquidation of long tail items [8]. Third, we exploit ad hoc retrieval models to compute neighborhoods in a collaborative filtering scenario [9, 10, 12]. Fourth, we explore the opposite direction by adapting an effective recommendation framework to pseudo-relevance feedback [13, 11]. Finally, we discuss the results and present our conclusions.
In summary, this doctoral thesis adapts a series of information retrieval models to recommender systems. Our investigation shows that many retrieval models can be accommodated to deal with different recommendation tasks. Moreover, we find that taking the opposite path is also possible. Exhaustive experimentation confirms that the proposed models are competitive. Finally, we also perform a theoretical analysis of some models to explain their effectiveness.

Advisors
: Álvaro Barreiro and Javier Parapar.

Committee members
: Gabriella Pasi, Pablo Castells and Fidel Cacheda.

The dissertation is available at: https://www.dc.fi.udc.es/~dvalcarce/thesis.pdf.
An Atlas of Phanerozoic Paleogeographic Maps: The Seas Come In and the Seas Go Out
Authors: Scotese Christopher R. 
Published: March 2021

Paleogeography is the study of the changing surface of Earth through time. Driven by plate tectonics, the configuration of the continents and ocean basins has been in constant flux. Plate tectonics pushes the land surface upward or pulls it apart, causing its collapse. All the while, the unrelenting forces of climate and weather slowly reduce mountains to sand and mud and redistribute these sediments to the sea. This article reviews the changing paleogeography of the past 750 million years. It describes the broad patterns of Phanerozoic paleogeography as well as many of the specific paleogeographic events that have shaped the modern continents and ocean basins. The focus is on the changing latitudinal distribution of the continents, fluctuations in sea level, the opening and closing of oceanic seaways, mountain building, and how these paleogeographic changes have affected global climate, ocean circulation, and the evolution of life. This review presents an atlas of 114 paleogeographic maps that illustrate how Earth's surface has evolved during the past 750 million years. During that time interval, Earth has witnessed the formation and breakup of two supercontinents: Pannotia and Pangea. The continents have been transformed from low-lying flooded platforms to high-standing land areas crisscrossed by the scars of past continental collisions. Oceans have opened and closed, and then opened again in a seemingly never-ending cycle. ▪  The changing configuration of the continents and ocean basins during the past 750 million years is illustrated in 114 paleogeographic maps. ▪  These maps describe how the surface of Earth has been continually modified by mountain building and erosion. ▪  The changing paleogeography has affected global climate, ocean circulation, and the evolution of life. ▪  The data and methods used to produce the maps are described in detail.
Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance
Authors: Tan Sze Kiat , Mahmud Iqbal , Fontanesi Flavia , Puchowicz Michelle , Neumann Chase K.A. , Griswold Anthony J. , Patel Rutulkumar , Dispagna Marco , Ahmed Hamzah H. , Gonzalgo Mark L. , Brown J. Mark , Garrett Timothy J. , Welford Scott M. 
Published: March 2021

Abstract

Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids and adipogenic transdifferentiation. We assessed adipokine expression in ccRCC and found that tumor tissues and patient plasma exhibit obesity-dependent elevations of the adipokine chemerin. Attenuation of chemerin by several approaches led to significant reduction in lipid deposition and impairment of tumor cell growth in vitro and in vivo. A multi-omics approach revealed that chemerin suppresses fatty acid oxidation, preventing ferroptosis, and maintains fatty acid levels that activate hypoxia-inducible factor 2α expression. The lipid coenzyme Q and mitochondrial complex IV, whose biogeneses are lipid-dependent, were found to be decreased after chemerin inhibition, contributing to lipid reactive oxygen species production. Monoclonal antibody targeting chemerin led to reduced lipid storage and diminished tumor growth, demonstrating translational potential of chemerin inhibition. Collectively, the results suggest that obesity and tumor cells contribute to ccRCC through the expression of chemerin, which is indispensable in ccRCC biology.

Significance:
Identification of a hypoxia-inducible factor–dependent adipokine that prevents fatty acid oxidation and causes escape from ferroptosis highlights a critical metabolic dependency unique in the clear cell subtype of kidney cancer. Targeting lipid metabolism via inhibition of a soluble factor is a promising pharmacologic approach to expand therapeutic strategies for patients with ccRCC.
See related commentary by Reznik et al., p. 1879.
This article is highlighted in the In This Issue feature, p. 1861
Asian Americans, Affirmative Action & the Rise in Anti-Asian Hate
Authors: Lee Jennifer 
Published: March 2021

Abstract
No court case in recent history has propelled Asian Americans into the political sphere like Students for Fair Admissions v. Harvard, and no issue has galvanized them like affirmative action. Asian Americans have taken center stage in the latest battle over affirmative action, yet their voices have been muted in favor of narratives that paint them as victims of affirmative action who ardently oppose the policy. Bridging theory and research on immigration, stereotypes, and boundaries, I provide a holistic portrait of SFFA v. Harvard and focus on Asian Americans' role in it. Immigration has remade Asian Americans from “unassimilable to exceptional,” and wedged them between underrepresented minorities who stand to gain most from the policy and the advantaged majority who stands to lose most because of it. Presumed competent and morally deserving, Asian Americans subscribe to the stereotype, and wield it to their advantage. Competence, moral worth, and respectability politics, however, are no safeguards against racism and xenophobia. As fears of the coronavirus arrested the United States, so too has the rise in anti-Asian hate.
Teaching Scriptures and Ecology
Authors: Person Raymond F. 
Published: March 2021

Abstract
Any course in religion and ecology can include some discussion of foundational texts, including a critical reading of the literary portrayal of other-than-humans. This article will focus on teaching scriptures and ecology as illustrated in a course entitled “The Bible and the Environment,” which introduces students to an ecojustice reading of the Christian Bible and secondary sources. The article also concerns my adaptation of Felder and Brent’s recommendations for encouraging students to actively engage in class discussion. Since I wanted to introduce more written reflection, I adapted their methods to giving pop quizzes at the beginning, middle, and end of some class sessions. This proved successful in that students were better prepared for class, were more attentive participants in class discussion, and had better comprehension of content, including the ability to apply the concepts of anthropocentrism and ecocentrism to primary and secondary sources.