bluuebunny/crossref_metadata_2025_split huggingface dataset:
A major asymmetric ice trap in a planet-forming disk
Authors: van der Marel Nienke , Booth Alice S. , Leemker Margot , van Dishoeck Ewine F. , Ohashi Satoshi 
Published: June 2021

Context. The chemistry of planet-forming disks sets the exoplanet atmosphere composition and the prebiotic molecular content. Dust traps are of particular importance as pebble growth and transport are crucial for setting the chemistry where giant planets form.
Aims. The asymmetric Oph IRS 48 dust trap located at 60 au radius provides a unique laboratory for studying chemistry in pebble-concentrated environments in warm Herbig disks with gas-to-dust ratios as low as 0.01.
Methods. We use deep ALMA Band 7 line observations to search the IRS 48 disk for H2CO and CH3OH line emission, the first steps of complex organic chemistry.
Results. We report the detection of seven H2CO and six CH3OH lines with energy levels between 17 and 260 K. The line emission shows a crescent morphology, similar to the dust continuum, suggesting that the icy pebbles play an important role in the delivery of these molecules. Rotational diagrams and line ratios indicate that both molecules originate from warm molecular regions in the disk with temperatures > 100 K and column densities ∼1014 cm−2 or a fractional abundance of ∼10−8 and with H2CO/CH3OH ∼0.2, indicative of ice chemistry. Based on arguments from a physical-chemical model with low gas-to-dust ratios, we propose a scenario where the dust trap provides a huge icy grain reservoir in the disk midplane, or an ‘ice trap’, which can result in high gas-phase abundances of warm complex organic molecules through efficient vertical mixing.
Conclusions. This is the first time that complex organic molecules have been clearly linked to the presence of a dust trap. These results demonstrate the importance of including dust evolution and vertical transport in chemical disk models as icy dust concentrations provide important reservoirs for complex organic chemistry in disks.
Resilienz in der Notfallmedizin
Authors: Hinzmann Dominik , Koll-Krüsmann Marion , Bogner-Flatz Viktoria , Schießl Andreas 
Published: June 2021

ZusammenfassungMitarbeitende im Gesundheitswesen stellen eine wichtige Ressource in unserer Gesellschaft dar. Gerade in Zeiten einer Pandemie wird der Mangel an Beschäftigten in der sogenannten kritischen Infrastruktur wie beim Blick durch eine Lupe deutlich.Besonders in der Akut-, Notfall- und Intensivmedizin stellen die Mitarbeitenden mit Fokus auf berufsbedingte psychische und physische Störungen eine Hochrisikogruppe dar. Um den damit verbundenen direkten Impakt auf die Patientensicherheit nicht zu gefährden, ist es wichtig, genau diese Personengruppe in ihrer täglichen Arbeit bestmöglich zu unterstützen.Im Folgenden werden nicht nur die aktuell häufig verwendeten Begrifflichkeiten wie Resilienz im Sinne der Widerstandsfähigkeit oder das Kohärenzgefühl genauer beleuchtet, sondern auch Maßnahmen zur Steigerung und Erhaltung der persönlichen Resilienz beschrieben.Neben den 3 Säulen der Prävention (primär, sekundär und tertiär) und den damit verbundenen Möglichkeiten werden auch mögliche Folgen nach potenziell traumatischen und beruflich bedingten Belastungen erläutert und die Maßnahmen zur Vermeidung und Reduktion von Traumafolgestörungen beschrieben. Am Beispiel der kollegialen Begleitung durch betrieblich ausgebildete Peers werden die ersten Maßnahmen und die theoretischen Grundlagen dahinter erklärt und bis zur Vermittlung in ein weiterführendes und potenziell behandelndes Netzwerk aufgezeigt.
Expression of the fructose transporter GLUT5 in patients with fructose malabsorption
Authors: Staubach Pia , Koch Anna Katharina , Langhorst Jost , Schreiber Stefan , Röcken Christoph , Helwig Ulf 
Published: June 2021

AbstractBackground Patients with abdominal symptoms are frequently diagnosed with fructose malabsorption (FM). Fructose is absorbed by monosaccharide transporters located in the brush border of the human small intestine. The aim of this study was to investigate the histoanatomical distribution of the main fructose transporter GLUT5.Materials and methods We studied 223 patients diagnosed with FM by a hydrogen breath test and grouped according to their response to a fructose-free diet. The control group were 42 healthy individuals and 29 patients with celiac disease (CD). The fructose breath test was done with 50 g fructose. The expression of Glut5 in duodenal biopsy specimens was studied by immunohistochemistry. The Kruskal-Wallis-test and Mann-Whitney U-test were used to carry out the statistical analysis.Results The histoanatomical expression pattern of GLUT5 did not differ significantly between those patients with FM who responded completely to a fructose-free diet (n = 183) and healthy individuals (n = 42); nor did it correlate to H2 production measured in fructose breath testing. In patients with FM, the GLUT5 expression pattern did not differ between those individuals responding to a fructose-free diet and those who did not. However, GLUT5 expression pattern was significantly different in patients with CD (n = 29) compared to patients with FM and to healthy individuals (p = 0.009).Conclusion GLUT5 expression patterns are not be related to adult patients with FM. However, in secondary malabsorption, a decreased GLUT5 expression was found. Further investigation is needed to understand the essential factors in FM and the influence on functional gastrointestinal disorders.
Methylation Alkynylation of Terminal Alkenes via 1,2-Alkynyl Migration Using Dicumyl Peroxide as the Methyl Source
Authors: Luo Yong-yue , Deng Wei , Xiang Jiannan , Qin Yi-qun , Chen De , Liu Liang , Zhang Jia-jia , Peng Xin-ju 
Published: June 2021

AbstractThe metal-free oxidative alkene methylation/alkynylation of 1,4-enyn-3-ols with an organic peroxide as the methyl source has been developed, which provides straightforward and practical access to the challenging quaternary-carbon-containing but-3-yn-1-ones. The method is reasoned to go through methylation of functional alkenes utilizing dicumyl peroxide as the methylating reagent and subsequent intermolecular cyclization/1,2-alkynyl migration. This reaction has an excellent functional group tolerance, broad substrate scope, and exquisite selectivity.
Type 2A and 2M von Willebrand Disease: Differences in Phenotypic Parameters According to the Affected Domain by Disease-Causing Variants and Assessment of Pathophysiological Mechanisms
Authors: Woods Adriana Inés , Paiva Juvenal , Primrose Débora Marina , Blanco Alicia Noemí , Sánchez-Luceros Analía 
Published: June 2021

AbstractType 2A and 2M von Willebrand disease (VWD) broadly show similar phenotypic parameters, but involve different pathophysiological mechanisms. This report presents the clinical and laboratory profiles of type 2A and type 2M patients genotypically diagnosed at one large center. Higher bleeding score values and a higher incidence of major bleeding episodes were observed in type 2A compared with type 2M, potentially reflective of the absence of large and intermediate von Willebrand factor (VWF) multimers in 2A. In type 2A, most of disease-causing variants (DCVs) appeared to be responsible for increased VWF clearance and DCV clustered in the VWF-A1 domain resulted in more severe clinical profiles. In type 2M, DCV in the VWF-A1 domain showed different laboratory patterns, related to either reduced synthesis or shortened VWF survival, and DCV in the VWF-A2 domain showed patterns related mainly to shortened survival. VWF-type 1 collagen binding/Ag (C1B/Ag) showed different patterns according to DCV location: in type 2A VWD, C1B/Ag was much lower when DCVs were located in the VWF-A2 domain. In type 2M with DCV in the VWF-A1domain, C1B/Ag was normal, but with DCV in the VWF-A2 domain, C1B/Ag was low. The higher frequency of major bleeding in VWD 2M patients with DCV in the VWF-A2 domain than that with DCV in the VWF-A1 domain could be a summative effect of abnormal C1B/Ag, on top of the reduced VWF-GPIb binding. In silico modeling suggests that DCV impairing the VWF-A2 domain somehow modulates collagen binding to the VWF-A3 domain. Concomitant normal FVIII:C/Ag and VWFpp/Ag, mainly in type 2M VWD, suggest that other nonidentified pathophysiological mechanisms, neither related to synthesis/retention nor survival of VWF, would be responsible for the presenting phenotype.
The Biological Significance of von Willebrand Factor O-Linked Glycosylation
Authors: Ward Soracha , O'Sullivan Jamie M. , O'Donnell James S. 
Published: June 2021

AbstractGlycosylation is a key posttranslational modification, known to occur on more than half of all secreted proteins in man. As such, the role of N- and O-linked glycan structures in modulating various aspects of protein biology is an area of much research. Given their prevalence, it is perhaps unsurprising that variations in glycan structures have been demonstrated to play critical roles in modulating protein function and have been implicated in the pathophysiology of human diseases. von Willebrand factor (VWF), a plasma glycoprotein that is essential for normal hemostasis, is heavily glycosylated, containing 13 N-linked and 10 O-linked glycans. Together, these carbohydrate chains account for 20% of VWF monomeric mass, and have been shown to modulate VWF structure, function, and half-life. In this review, we focus on the specific role played by O-linked glycans in modulating VWF biology. Specifically, VWF O-linked glycans have been shown to modulate tertiary protein structure, susceptibility to ADAMTS13 proteolysis, platelet tethering, and VWF circulatory half-life.
Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection
Authors: Hu Hong-bo , Wu Jian-gang , Sun Jian-jun , Peng Qiao-ying , Shang Xiao-peng 
Published: June 2021

Abstract
Objective Cytomegalovirus (CMV) virulence may depend on genetic variability in several regions of the genome. This study aimed to assess specific CMV genotypes' association with the severity of symptomatic congenital CMV disease at birth.
Methods CMV glycoprotein B (gB), glycoprotein N (gN), glycoprotein H (gH), and UL144 strains were identified by nested polymerase chain reaction, restriction fragment length polymorphism, and heteroduplex mobility assay single-stranded conformation polymorphism in 50 infants infected congenitally and 25 asymptomatic infants.
Results gN1 (p = 0.010) and UL144-B (p = 0.034) genotypes were associated, by logistic regression, with reduced risk of developing symptomatic congenital CMV infection. gN1 (p = 0.020) and gN3 (p = 0.022) genotypes were associated with reduced risk of severe symptomatic disease. Conversely, gB1 (p = 0.018) was the most virulent genotype and was associated with severe symptoms.
Conclusion An association among gB1, gN1, gN3, and UL144-B genotypes of CMV and severity of congenital CMV disease might exist. gB, gN, and UL144 genotypes could be important virological markers of infant infection.
A Novel Measurement Using Digital Radiography to Minimize Fluoroscopy in Total Hip Arthroplasty
Authors: Yun Andrew G. , Qutami Marilena , Pasko Kory B. Dylan 
Published: June 2021

AbstractPreoperative templating for total hip arthroplasty (THA) is fraught with uncertainty. Specifically, the conventional measurement of the lesser trochanter to the center (LTC) of the femoral head used in preoperative planning is easily measured on a template but not measurable intraoperatively. The purpose of this study was to examine the utility of a novel measurement that is reproducible both on templating and in surgery as a more accurate and practical guide. We retrospectively reviewed 201 patients with a history of osteoarthritis who underwent primary THA. For preoperative templating, the distance from the top of the lesser trochanter to the equator (LeTE) of the femoral head was measured on a calibrated digital radiograph with a neutral pelvis. This measurement was used intraoperatively to guide the choice of the trial neck and head. As with any templating technique, the goal was to construct a stable, impingement-free THA with equivalent leg lengths and hip offset. In evaluating this novel templating technique, the primary outcomes measured were the number of trial reductions and the amount of fluoroscopic time, exposures, and radiation required to obtain a balanced THA reconstruction. Using the LeTE measurement, the mean number of trial reductions was 1.21, the mean number of intraoperative fluoroscopy images taken was 2.63, the mean dose of radiation exposure from fluoroscopy was 0.02 mGy, and the mean fluoroscopy time per procedure was 0.6 seconds. In hips templated with the conventional LTC prior to the LeTE, the mean fluoroscopy time was 0.9 seconds. There was a statistically significant difference in fluoroscopy time (p < 0.001). The LeTE is a reproducible measurement that transfers reliably from digital templating to surgery. This novel preoperative templating metric reduces the fluoroscopy time and consequent radiation exposure to the surgical team and may minimize the number of trial reductions.
Neurological Complications of Cardiac Procedures
Authors: Hrdlicka Courtney M. , Wang Jeffrey , Selim Magdy 
Published: June 2021

AbstractNeurological complications after cardiac surgery and percutaneous cardiac interventions are not uncommon. These include periprocedural stroke, postoperative cognitive dysfunction after cardiac surgery, contrast-induced encephalopathy after percutaneous interventions, and seizures. In this article, we review the incidence, pathophysiology, diagnosis, and management of these complications. Improved understanding of these complications could lead to their prevention, faster detection, and facilitation of diagnostic workup and appropriate treatment.
Immature Platelet Fraction: Its Clinical Utility in Thrombocytopenia Patients
Authors: Goel Garima , Semwal Shruti , Khare Akriti , Joshi Deepti , Amerneni Chaitanya K. , Pakhare Abhijit , Kapoor Neelkamal 
Published: June 2021

AbstractObjectives Etiology of thrombocytopenia is multifactorial and its pathogenesis should be distinguished for appropriate management. Newly formed immature platelets are called reticulated platelets (RPs) and can be estimated in peripheral blood using automated hematology analyzers, which express them as immature platelet fraction (IPF). In the present study we intend to assess and establish the clinical utility of IPF in differentiating the two major causes of thrombocytopenia—decreased production and increased destruction of platelets—along with determining its significance in monitoring patients with thrombocytopenia.Materials and Methods Sixty-one cases of thrombocytopenia and 101 healthy controls with normal platelet count were included in the study. IPF and all the other usual blood cell parameters were measured using a fully automated hematology analyzer. Based on the pathogenesis of thrombocytopenia, the cases were divided into groups and the difference in IPF value between the groups was evaluated.Results The reference range of IPF among healthy controls was estimated to be 0.7 to 5.7%. The mean IPF was significantly higher in patients with increased peripheral destruction of platelets (13.4%) as compared to patients with decreased production of platelets (4.6%). The optimal cutoff value of IPF for differentiating patients with increased peripheral destruction of platelets from patients with decreased production of platelets was 5.95% with a sensitivity of 88% and specificity of 75.9%.Conclusion Measurement of IPF is useful for detecting evidence of increased platelet production and helps in the initial evaluation of thrombocytopenia patients. It is a novel diagnostic method which can be used to differentiate patients with thrombocytopenia due to increased destruction of platelets from patients with thrombocytopenia due to bone marrow failure/suppression.
Can Lactate Clearance Predict Mortality in Critically Ill Children?
Authors: Moustafa Azza A. , Elhadidi Abeer S. , El-Nagar Mona A. , Hassouna Hadir M. 
Published: June 2021

AbstractSerial evaluation of blood lactate, including lactate clearance, may have greater value over single measurement at the time of presentation. The rationale of the current study was to evaluate the use of lactate clearance after 6 hours of admission to pediatric intensive care unit (PICU) as a predictor of mortality in critically ill children. A prospective observational study was conducted in a nine-bed PICU of a tertiary care teaching hospital over a period of 6 months. Lactate levels were measured in arterial blood samples of 76 patients at the time of admission and 6 hours later. According to calculated lactate clearance, patients were divided into group A (lactate clearance more than 0) which included 71% of patients and group B (lactate clearance ≤0) which included 29% of patients. Lactate level at admission was a poor predictor of mortality (area under receiver operating characteristic curve [AUC] = 0.519, p = 0.789). Lactate clearance after 6 hours of admission was a significant predictor of mortality (AUC = 0.766, p < 0.001). Using Kaplan–Meier survival curve, overall survival was significantly better among group A (p < 0.001). Using multivariate logistic regression model, lactate clearance after 6 hours (odds ratio = 0.98, 95% confidence interval [CI]: 0.96–0.99) and The Pediatric Index of Mortality 2 (PIM2) score (odds ratio = 4.7, 95% CI: 1.85–12.28) had independent prognostic significance with regard to mortality (p = 0.030, 0.001 respectively). We conclude that lactate clearance after 6 hours of admission can predict mortality in critically ill children.
Fathers' Heightened Stress Responses to Recounting their NICU Experiences Months after Discharge: A Mixed Methods Pilot Study
Authors: Fronheiser Brittany J. , Ali Saher , Gardner Fumiyuki C. , Hozella Alexia C. , Brelsford Gina M. , Doheny Kim K. 
Published: June 2021

Objective The acute and traumatic events associated with having a newborn who requires admission to the neonatal intensive care unit (NICU) may elicit long-term concerns for parents postdischarge. Cognitive processing of taxing events influences recurring stress responses, which can be inferred via biomarkers such as salivary cortisol (sCort) and skin conductance (SC). In addition, personal narratives provide an important insight into individual perceptions and coping strategies. The current pilot study aimed to (1) test the hypotheses that fathers' sCort and SC would peak in response to stress induction and decrease during recovery, (2) examine associations among stress biomarkers and stress perceptions, (3) explore fathers' narratives using thematic analysis, and (4) integrate fathers' narrative themes with their stress responsivity.Study Design Using a convergent mixed methods approach, we enrolled 10 fathers of infants formerly cared for in NICU who underwent a Trier Social Stress Test including recounting their NICU experience months postdischarge. Stress responsivity was measured via sCort and SC, while stress perceptions were identified by using the Perceived Stress Scale and Distress Thermometer-Parent. Personal narratives were explored by using thematic analysis.Results The significant rise in fathers' sCort and SC in response to stress induction was reflected in narrative themes including loss, worry, and role strain. Subsequently, fathers' sCort and SC returned to baseline, which was illustrated by themes such as role strength, coping, and medical staff interactions. Fathers' stress measured by PSS was lower than that required for mental health referral, and did not correlate with stress biomarkers.Conclusion Salivary cortisol and skin conductance are useful biomarkers of paternal stress responsivity and recovery. Thematic analysis identified fathers' NICU stressors and coping strategies that mirrored their stress responsivity patterns. Further studies are needed to more broadly examine the sociodemographic variables that influence stress reactivity and perceptions in parents of infants formerly cared for in NICU.Key Points
Paradox of the duplication of physical information
Authors: Ryabkov Maxim 
Published: June 2021

AbstractA thought experiment demonstrates that physicalism about consciousness entails a paradoxical duplication of physical information. Moreover, objective existence acquires the status of a physical property. To avoid this paradox, one requires a concept of objectivity in which individuation is finite and incomplete. Finite individuation requires objective uncertainty and is thus corroborated by the contemporary sciences. Finite individuation and objective uncertainty prevent existence from becoming a physical property, thus defeating physicalism about consciousness and resolving the paradox.
Performance characteristics of low threshold current 1.25 μm type-II GaInAs/GaAsSb ‘W’-lasers for optical communications
Authors: Duffy Dominic A , Marko Igor P , Fuchs Christian , Eales Timothy D , Lehr Jannik , Stolz Wolfgang , Sweeney Stephen J 
Published: June 2021

Abstract
Type-II ‘W’-lasers have made an important contribution to the development of mid-infrared laser diodes. In this paper, we show that a similar approach can yield high performance lasers in the optical communications wavelength range. (GaIn)As/Ga(AsSb) type-II ‘W’ structures emitting at 1255 nm have been realised on a GaAs substrate and exhibit low room temperature threshold current densities of 200–300 A cm−2, pulsed output powers exceeding 1 W for 100 µm wide stripes, and a characteristic temperature T
0 ≈ 90 K around room temperature. Optical gain studies indicate a high modal gain around 15–23 cm−1 at 200–300 A cm−2 and low optical losses of 8 ± 3 cm−1. Analysis of the spontaneous emission indicates that at room temperature, up to 24% of the threshold current is due to radiative recombination, with the remaining current due to other thermally activated non-radiative processes. The observed decrease in differential quantum efficiency with increasing temperature suggests that this is primarily due to a carrier leakage process. The impact of these processes is discussed in terms of the potential for further device optimisation. Our results present strong figures of merit for near-infrared type-II laser diodes and indicate significant potential for their applications in optical communications.