bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photoluminescent gels based on han purple: new frontiers in biotechnology
Authors: Feliciano Santos Karina , Yamamoto Morassuti Claudio , Alves Ribeiro Daniela , Souza Carvalho Karoline Victoria , Sabino Gutierres Marcos Antonio , Kelmy Macário Barboza Daguano Juliana , Lopes da Silva Jorge Vicente 
Published: December 2024

As a result of the increasing need for new biocompatible materials, polymer-based gels have become promising options. Lately, photoluminescent gels have shown potential for applications in biotechnology and non-invasive tracking due to their ability to emit light when temperature changes occur. This research investigates the incorporation of Han Purple (HP) pigment into a polyethylene glycol/Laponite matrix [92,5/7,5%] (P7LHP0%) to produce a 3D-printed gel. The gels were examined for possible use as smart sensors, focusing on their optical and thermal characteristics. Formulations with HP concentrations of 0.0%, 0.5%, and 2.0% were prepared, followed by extrusion-based 3D printing. Characterization techniques included FTIR, SEM, and optical analyses (emission and excitation spectra). The findings showed 3D structures with good shape fidelity while FTIR indicated suitable compatibility between HP and the matrix. Optical analysis revealed fluorescence with an excitation band between 400 and 700 nm, with a maximum at 620 nm, and an emission band at 830 - 1000 nm with a peak at 925 nm. This study highlights the potential of HP as a promising material for fluorescent gels in 3D printing, creating new opportunities for biotechnology applications
- SOSIALISASI TENTANG PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) DI SEKOLAH
Authors: Sayati Dewi Sayati 
Published: December 2024

Dampak yang akan timbul apabila PHBS kurang diterapkan di sekolah yaitu terjadi penurunan prestasi dan semangat belajar, menurunkan citra sekolah, suasana belajar yang tidak mendukung karena lingkungan sekolah yang kotor, keadaan kelas yang kotor, banyaknya jajanan tidak sehat dan tempat pembuangan sampah yang tidak tertata akan menimbulkan berbagai macam penyakit, dampak lain yang akan timbul adalah munculnya penyakit seperti diare. Sebagaimana data profil kesehatan Kota Palembang tahun 2022, jumlah kasus diare di Kota Palembang tahun 2021 yang tercatat sebanyak 46,400 kasus. Jumlah tersebut merupakan penyakit potensial KLB yang sering disertai dengan kematian. Tujuan kegiatan ini untuk meningkatkan pengetahuan siswa dan siswi tentang PHBS di Sekolah beserta indikator PHBSnya serta meningkatkan kesadaran siswa dan siswi terhadap pelaksanaan PHBS di sekolah dan selalu mengaplikasikannya dalam kehidupan sehari-hari. Metode pelaksanaan kegiatan Pengabdian Kepada Masyarakat yaitu berupa sosialisasi atau penyuluhan dengan metode ceramah pada peserta di SMP Puja Handayani Palembang, kemudian diberikan leaflet tentang Sosialisasi Tentang Perilaku Hidup Bersih dan Sehat (PHBS) di Sekolah sebanyak 30 peserta. Berdasarkan hasil evaluasi terhadap pengetahuan siswa tentang PHBS di sekolah saat pengabdian masyarakat yaitu para siswa/siswi yang menunjukkan adanya peningkatan pengetahuan dan pemahaman tentang materi yang diberikan dengan jumlah skor lebih atau sama dengan 89%. Materi yang disampaikan dapat dimengerti oleh seluruh peserta sosialisasi dan juga materi yang diberikan dirasakan sangat bermanfaat, yang pada akhirnya dapat merubah perilaku siswa/siswi di SMP Puja Handayani Palembang ke arah yang lebih baik dan positif yaitu menyadari akan pentingnya menerapkan PHBS Di Sekolah maupun dalam kehidupan sehari-hari. Kesimpulannya bahwa meningkatnya pengetahuan dan pemahaman para peserta sosialisasi tentang PHBS di sekolah. Disarankan kepada seluruh peserta yang belum tahu dan paham tentang PHBS Di Sekolah, agar dapat meningkatkan pengetahuan dan pemahamannya PHBS Di Sekolah pada SMP Puja Handayani Palembang.
МИГРАЦИЯ - СОЦИУМДУН МЫЙЗАМ ЧЕНЕМДҮҮ ТАБИГЫЙ КӨРҮНҮШҮ
Authors: Акаев Аскар , Эркебаев Элес 
Published: December 2024

Аталган макалада Кыргызстандын миграциялык саясаты улуттук диаспораларды сактоого, республиканын эмгек ресурстарын сарамжалдуу пайдаланууга багытталгандыгы туурасында айтылат. Этномиграциялык саясат стратегиясындагы борбордук звено болуп улуттук диаспораларга колдоо көрсөтүү жана сактоо боюнча комплектсүү иш-чараларды иштеп чыгуу жана жүзөгө ашыруу (баарынан мурда орус, украин ж.б.) эсептелет. Адамдын укугун анын улутуна карабастан коргоону камсыз кылып, кадр саясатынын жүзөгө ашыруудагы басымды алмаштырып, улуттан тышкаркы кадр саясатын жүргүзүү үчүн негиздерди иштеп чыгуу керек. Республиканын бардык негизги улуттарынын – биринчи кезек орус тилдериндеги билим берүүчүлүк программаларды сактоо чон мааниге ээ. Мамлекет коомдун жашоосунун бардык чөйрөсүндөгү орус тилинин ролуна ар тараптан колдоо көрсөтүүсү абзел.
Knowledge, Attitude, and Practice Towards PMTCT of HIV/AIDS among HIV-Positive Mothers in PHC Minna, Niger State
Authors: Bello Umar Addakano , Abubakar Waziri Ismaila , Argungu Zulkiflu , Abdulrahman Kombo Salihu , Mohammad Sani Sani 
Published: December 2024

Mother-to-child transmission (MTCT) of HIV may occur during pregnancy, labor, and after childbirth, with 10–15% of the highest risks during breastfeeding. This problem is significant in the Sub-Saharan African countries, of which Nigeria is inclusive, where more than 80% of children living with HIV are found, with over 10,000 new pediatric HIV infections per year and a 26.9% MTCT transmission rate in 2017. Thus, this study assesses the knowledge, attitude, and practice towards PMTCT of HIV. A cross-sectional descriptive survey design was employed for the study, a multistage sampling method with a proportional allocation of samples to each Primary Health Care Center, and systematic simple random sampling were used to select 175 study participants. The Instrument for data collection was a self-administered questionnaire developed by the researchers based on the study objectives guided by previous studies, the instrument was pilot-tested and had a reliability Cronbach alpha coefficient of 0.738. Data collected were analyzed using SPSS version 25.0, descriptive statistics were used to describe the frequency distribution and are presented using frequency tables and percentages. The study finding shows that the respondent’s level of knowledge is high (62.6%), the attitude was positive (3.1), and practice was good (70.2%) towards the prevention of mother-to-child transmission (PMTCT) of HIV respectively. In this study, the respondents' level of knowledge was good, their attitude was positive, and their practice was good for PMTCT of HIV. This finding also reveals that healthcare providers are doing a good job in providing counseling sessions and knowledge of PMTCT to pregnant women attending antenatal care. Though, much is needed to increase their acceptance and use of PMTCT for HIV services.
Welcome to Materials and Interfaces
Authors: Xia Younan 
Published: December 2024

Editorial
Welcome to Materials and Interfaces

Younan Xia 1,2

1 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA; younan.xia@bme.gatech.edu
2 School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
Received: 16 December 2024; Accepted: 17 December 2024; Published: 20 December 2024
Cardiovascular involvement in multisystem inflammatory syndrome in children and midterm follow-up from a pediatric tertiary center in India
Authors: Varadarajan Poovazhagi , Solomon Ritchie Sharon , Subramani Seenivasan , Subramanian Ramesh , Srividya Gomathy , Raghunathan Elilarasi 
Published: December 2024

BACKGROUND
In multisystem inflammatory syndrome in children (MIS-C) with coronavirus disease 2019, there was paucity of data from low-income and middle-income countries on cardiovascular involvement and its longitudinal outcomes. We planned to estimate the pattern of cardiovascular involvement among children with MIS-C and its mid-term outcomes.
AIM
To determine association between cardiovascular abnormalities and clinical and laboratory parameters. To study the time-line for resolution of various abnormalities.
METHODS
In this prospective study done in a tertiary care hospital, 270 were recruited from June 2020 to January 2022. Baseline demographic data and clinical presentation were recorded. Laboratory parameters and echocardiography were done at admission. Follow-up was done at 2 weeks, 3 months, 6 months and 1 year after diagnosis. Descriptive statistics were used for parametric and non-parametric data. Risk factors were identified by multivariate regression analysis.
RESULTS
The 211 (78.2%) had cardiac involvement and 102 needed intensive care unit (ICU) admission. Cardiovascular abnormalities observed were shock 123 (45.6%), coronary dilatation 28 (10.4%), coronary aneurysm 77 (28.5%), left ventricular (LV) dysfunction 78 (29.3%), mitral regurgitation (MR) 77 (28.5%) and pericardial effusion 98 (36.3%). Coronary artery aneurysm/dilatation during follow-up at 2 weeks and 1 year were 25.7% and 0.9% respectively. Multivariate regression analysis revealed breathlessness [odds ratio (OR) = 3.91, 95%CI: 1.25-12.21, P = 0.019] and hi-flow nasal cannula (HFNC) support (OR = 8.5, 95%CI: 1.06-68.38, P = 0.044) as predictors of cardiovascular involvement. Higher mean age (OR = 1.16, 95%CI: 1.02-1.32, P = 0.026), breathlessness (OR = 4.99, 95%CI: 2.05-12.20, P < 0.001), gallop (OR = 4.45, 95%CI: 0.41-2.52, P = 0.016), MR (OR = 3.61, 95%CI: 1.53-8.53, P = 0.004) and invasive ventilation (OR = 4.01, 95%CI: 1.28-12.58, P = 0.017) were predictive of LV dysfunction. Altered sensorium (OR = 4.96, 95%CI: 2.23-11.02, P < 0.001), headache (OR = 6.61, 95%CI: 1.46-29.92, P = 0.014), HFNC (OR = 7.03, 95%CI: 2.04-24.29, P = 0.002), non-rebreathing mask usage (OR = 21.13, 95%CI: 9.00-49.61, P < 0.001) and invasive ventilation (OR = 5.64, 95%CI: 1.42-22.45, P = 0.014) were risk factors for shock. Anemia was a risk factor for coronary involvement (OR = 3.09, 95%CI: 1.79- 5.34, P < 0.001).
CONCLUSION
Significant number of children with MIS-C had cardiovascular involvement contributing to higher ICU management. Although shock resolved quickly, resolution of ventricular function and coronary abnormalities were slower, and hence warrants a structured long-term follow-up protocol.
Diet fortification for mild and moderate picky eating in typically developed children: Opinion review of Middle East consensus
Authors: Al-Beltagi Mohammed , Choueiry Elie , Alahmadi Najat , Demerdash Zeinab , Helmi Ayesh Wafaa , Al-Said Khoula , Al-Haddad Fatima , Shaaban Sanaa Y , Tawfik Eslam 
Published: December 2024

BACKGROUND
Picky eating is a commonly observed behavior among children globally, negatively impacting their physical and mental growth. Although common characteristics distinguish peaky eaters, including food selectivity, food neophobia, and food avoidance, there is no clear definition to assess this behavior. Due to the unavailability of data regarding picky eating, it wasn’t easy to estimate its prevalence.
AIM
To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.
METHODS
A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating. The discussion covered different topics, including clearly defining mild and moderate picky eating, identifying the role of diet fortification in these cases, and the possibility of developing a systematic approach to diet fortification.
RESULTS
The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food. Most of the time, moderate picky eating cases had micronutrient deficiencies with over- or undernutrition; the mild cases only showed inadequate food consumption and/or poor diet quality. Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags, including food fixation and anticipatory gagging, will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children. Although dietary supplementation and commercial food fortification play an important role in picky eating, they were no benefit in the Middle East.
CONCLUSION
The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children. These recommendations would facilitate identifying and managing picky-eating children in the Middle East.
Autologous cord blood vs individualized supplements in autistic spectrum disorder: CORDUS study results
Authors: Stancioiu Felician A , Bogdan Raluca , Ivanescu Bogdan , Dumitrescu Radu 
Published: December 2024

BACKGROUND
Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder (ASD), and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell therapies. Stem cells have yielded so far mixed results in clinical trials, and at patient level the results varied from impressive to no improvement. In this context we have administered autologous cord blood (ACB) and a non-placebo, material intervention represented by an individualized combination of supplements (ICS) to ASD children.
AIM
To compare the efficacy of ACB vs ICS and find markers correlated with the child's progress in order to better predict ACB efficacy.
METHODS
CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children; ACB was infused as an inpatient procedure. Treatment efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist, Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score, after interviewing the children’s parents and therapists. Before and after each intervention participants had a set of blood tests including inflammatory, metabolic and oxidative markers, and the neuronal specific enolase.
RESULTS
No serious adverse reactions were noted during and after cord blood or supplement administration. ACB improved evaluation scores in 78% of children with age 3–7-years (n = 28), but was much less effective in kids older than 8 years or with body weight of more than 35 kg (n = 28; only 11% of children improved scores). ICS yielded better results than ACB in 5 cases out of 28, while in 23 kids ACB brought more improvement than ICS (P < 0.05); high initial levels of inflammation and ferritin were associated with no improvement. Ample individual differences were noted in children's progress, and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction, but not on irritability or aggressive behavior.
CONCLUSION
ACB has superior efficacy to ICS in ASD; high inflammation, ferritin, age and body weight predict less improvement; more clinical studies are needed for studying ACB efficacy in ASD.
Importance of neonatal screening: A case study of sickle cell disease and cystic fibrosis coexistence
Authors: Magalhães Nathalia Noyma Sampaio , Mathiasi Lucas Barra , Werneck Rodrigues Daniela de Oliveira 
Published: December 2024

BACKGROUND
Neonatal screening (NS) is a public health policy to identify genetic pathologies such as cystic fibrosis (CF), sickle cell disease, and other diseases. Sickle cell disease is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin S. CF is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane regulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface epithelium. NS is crucial for early diagnosis and management, which ensures a better quality of life.
AIM
To report a case of the coexistence of sickle cell anemia (SCA) and CF and perform an integrative literature review.
METHODS
This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical case. The authors identified only 5 cases of SCA associated with CF. No clinical trials or review articles were identified considering the rarity of the coexistence of these two pathologies.
RESULTS
Herein, the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with SCA with an alteration in the dosage of immunoreactive trypsin. The diagnosis of CF was confirmed by the Coulometry Sweat Test. The rarity of the co-occurrence of these two severe genetic pathologies (CF and SCA) is a challenge for medical science.
CONCLUSION
This study adds to the few case reports present in the literature that highlight the identification of two severe diseases via NS.
Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction: A case-control study
Authors: Giorgio Valentina , Venezia Ilaria , Pensabene Licia , Blasi Elisa , Rigante Donato , Mariotti Paolo , Stella Giuseppe , Margiotta Gaia , Quatrale Giovanna , Marano Giuseppe , Mazza Marianna , Gasbarrini Antonio , Gaetani Eleonora 
Published: December 2024

BACKGROUND
Disorders of gut-brain interaction (DGBI) are common, but knowledge about their physiopathology is still poor, nor valid tools have been used to evaluate them in childhood.
AIM
To develop a psycho-gastroenterological questionnaire (PGQ) to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without DGBI.
METHODS
One hundred and nineteen Italian children (age 11-18) were included: 28 outpatient patients with DGBI (Rome IV criteria) and 91 healthy controls. They filled the PGQ, faces pain scale revised (FPS-R), Bristol stool chart, gastrointestinal symptoms rating scale, state-trait anxiety inventory, Toronto alexithymia scale 20, perceived self-efficacy in the management of negative emotions and expression of positive emotions (APEN-G, APEP-G), irritable bowel syndrome-quality of life questionnaire, school performances, tobacco use, early life events, degree of digitalization.
RESULTS
Compared to controls, patients had more medical examinations (35% of them went to the doctor more than five times), a higher school performance (23% vs 13%, P < 0.05), didn’t use tobacco (never vs 16%, P < 0.05), had early life events (28% vs 1% P < 0.05) and a higher percentage of pain classified as 4 in the FPS-R during the examination (14% vs 7%, P < 0.05).
CONCLUSION
Pediatric outpatients with DGBI had a higher prevalence of early life events, a lower quality of life, more medical examinations rising health care costs, lower anxiety levels.
Роль права в противостоянии России «гибридному геноциду»
Authors: Махтюк С.О. , Черданцев А.Ю. 
Published: December 2024

В настоящей работе авторами рассматривается понятие геноцида, раскрывается его актуальное содержание с учетом современной правовой и политико-экономической действительности. Утверждается комплексный и разновекторный характер геноцида в эпоху «второй холодной войны», который включает в себя проявления в социальной сфере, в областях истории, культуры, экономики и, безусловно, права. Предложен и обоснован с научно-практической точки зрения термин «гибридный геноцид». Приводя в пример конкретные действия и решения стран «коллективного Запада» в отношении населения Российской Федерации, авторы демонстрируют, что в сегодняшнем мире геноцид не является простой линейной связью между преступными действиями и мгновенным причинением вреда. Сделан вывод, что геноцид следует рассматривать как сложное явление, зачастую имеющее отложенные (но оттого не менее тяжкие) последствия для пострадавшей стороны. В статье утверждается, что борьбу с гибридным геноцидом следует вести комплексно и адекватно возникающим вызовам. Основным и наиболее эффективным инструментом такой борьбы является оптимизация правового регулирования как внутригосударственных процессов, так и механизмов международного взаимодействия.
The article examines the concept of genocide, reveals its actual content, taking into account modern legal and political-economic reality. The authors assert the complex and multidirectional nature of genocide in the era of the “Second Cold War”, which includes manifestations in the social sphere, in the fields of history, culture, economics and law. The term “hybrid genocide” is proposed and substantiated from a scientific and practical point of view. The authors give an example of specific actions and decisions of the countries of the “collective West” against the population of the Russian Federation and demonstrate that in today's world genocide is not a simple linear relationship between criminal actions and instant harm. The article concludes that genocide should be considered as a complex phenomenon, often having delayed (but therefore no less grave) consequences for the affected party. The article argues that the fight against hybrid genocide should be conducted in a comprehensive manner and adequately to the emerging challenges. The main and most effective tool for such a struggle is the optimization of legal regulation of both domestic processes and mechanisms of international interaction.
Особенности процедуры допроса несовершеннолетнего потерпевшего на стадии предварительного расследования
Authors: Абрамкин А.Д. 
Published: December 2024

В статье рассмотрены некоторые особенности процедуры допроса несовершеннолетнего потерпевшего на стадии предварительного расследования. Проанализирована судебная практика, раскрывающая некоторые особенности допроса несовершеннолетних лиц. Выявлены проблемные вопросы, возникающие при допросе несовершеннолетнего лица с участием педагога (психолога) из числа сотрудников органов внутренних дел. Сформулирован вывод о необходимости разработки соглашений между органом местного самоуправления в сфере образования и управлением МВД субъекта либо следственным управлением Следственного комитета Российской Федерации в каждом субъекте России.
The article discusses some features of the procedure for interrogating a minor victim at the stage of preliminary investigation. Judicial practice is analyzed, revealing some features of the interrogation of minors. Problematic issues that arise during the interrogation of a minor with the participation of a teacher (psychologist) from among internal affairs officers are identified. The conclusion is formulated about the need to develop agreements between the local government body in the field of education and the department of the Ministry of Internal Affairs of the subject or the investigative department of the Investigative Committee of the Russian Federation in each subject of Russia.