bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Regulation in Dual Diagnosis: A Multi-Method Approach of Self-Awareness, Error-Monitoring and Emotional Distress
Authors: Beerten-Duijkers Judith C.L.M. , Vissers Constance Th.W.M. , Rinck Mike , Egger Jos I.M. 
Published: March 2021

Introduction: Self-regulatory actions direct the achievement of life goals. Awareness of one's state is needed to adequately self-regulate one's life. Methods: The self-regulatory actions of (cognitive/emotional) self-awareness and (error-)monitoring were assessed in patients with Dual Diagnosis and healthy controls. A multi-method approach was applied. Results: Patients with Dual Diagnosis reported lower capacity to identify, verbalize and interpret emotions in a cognitive manner. Both groups reported experiencing arousal of emotions, but patients showed less cognitive elaboration on them and they reported more negatively labeled emotions. Patients with Dual Diagnosis signaled errors less adequately, but did not differ in the number of errors. Discussion: The abundance of negative emotions may overwhelm patients and trigger substance use to handle this negativity. Especially because they do in fact experience the arousal of emotions, but they find it harder to timely identify, interpret and verbalize these emotions. Training self-awareness and emotion regulation may be beneficial.
The Transversal Seismicity Action RESIF: A Tool to Improve the Distribution of the French Seismicity Products
Authors: Masson Frédéric , Auclair Samuel , Bertil Didier , Grunberg Marc , Hernandez Bruno , Lambotte Sophie , Mazet-Roux Gilles , Provost Ludmila , Saurel Jean-Marie , Schlupp Antoine , Sira Christophe 
Published: March 2021

Abstract
In recent years, the French seismological, geodetic, and gravimetric community has been structured within Réseau Sismologique et géodésique Français (RESIF) (French seismological and geodetic network). In addition to instrumental developments, RESIF has structured the work on French seismicity (metropolitan and overseas) within the RESIF transverse seismicity action (ATS). The purpose of this article is to present the ATS and the way it is structured to propose to the community different products: seismicity bulletin and catalog, historical and instrumental macroseismicity data, and ShakeMaps. The places where these products can be found are indicated, as well as the way they are realized and the improvements in progress for a better realization and availability. The link with European plate observing system is also underlined.
Calculating non-centrality parameter for power analysis under structural equation modelling: An alternative
Authors: Adedia David , Adebanji Atinuke O. , Appiah Simon K. 
Published: March 2021

Identifying the most parsimonious model in structural equation modelling is of utmost importance and the appropriate power estimation methods minimize the probabilities of Type I and Type II errors. The power of a test depends on the sample size, Type I error, degrees of freedom and effect size. In this study, a modified approach of using effect size in calculating the non-centrality parameter for power is proposed. This is compared to the approach in Maccallum et al. (1996) at different degrees of freedom and sample size specifications --- taken from 50 to 2000. As the sample size increased the difference between the power of a test for both methods reduced to zero. The results showed that the values for power of a test are the same for the modified and original approaches for large sample sizes and degrees of freedom. The findings also revealed that the sample discrepancy function ($\hat{F}$) is asymptotically unbiased.
Use of carbon plates for the treatment of supracondylar femoral fractures: preliminary experience
Authors: Puma Pagliarello Calogero , Ciatti Corrado , Burgio Valeria , Di Stefano Giovanni , Rivera Fabrizio , Quattrini Fabrizio , Pavone Vito , Scaravilli Gabriele , Maniscalco Pietro 
Published: March 2021

INTRODUCTION
Distal femur fractures in adults have an estimated annual incidence of 6% of all femur fracture. Choice of the type of fixation depends on the characteristics of the fracture and the general condition of the fractures Carbon fiber reinforced—polyetheretherketone (CFRPEEK) offer several potential benefits when compared with metal alloy implants, including a modulus of elasticity approaching cortical bone and fatigue strengths greater than most metals.
MATERIAL AND METHODS
We retrospectively identified treat 17 patients, treated with minimally invasive plate osteosynthesis (MIPO) with carbon plates (Piccolo Composite ®). The patients were evaluated with clinical and radiographic follow-up at 1 month, 3 month, 6 month e 1 year. The clinical evaluation was performed using knee society score (KSS) and the CAS score.
RESULTS
Clinically 15 of 17 patients examined healed (88,2 %), 1 patient (5,8 %)went to delay of consolidation healed in 11 month), 1 (5,8 %) patients went to non-union and we perform a revision arthroplasty. The mean healing time was 92,88 days (st. dev 28,63, min. 56 d – max 140). The mean CAS score at 1 year was 4,47 (st. dev 1,46, min 2 – max 6). The mean KSS at 1 year was 73,11
DISCUSSION
Titanium has good osseointegrative properties and an elastic modulus more similar to bone. Carbon plates with a stiffness closer to the 159 modulus of elasticity of bone, and exhibiting better fatigue properties, could be a good alternative to existing metallic plates. Our group of patients showed average healing time of about three months, but the formation of callus is evident as early as 1 month after surgery. For this reason a partial weight bearing was early allowed in 15 patients. Which guarantees a recovery of daily activities from 5 months after surgery, reducing the risk of mortality.
CONCLUSION
The new carbon plates guarantee the possibility of performing a more elastic synthesis that is closer to the biological characteristics of the bone.
Educar para ler desde a infância
Authors: Fronckowiak Ângela Cogo , Barbosa Maria Carmen Silveira 
Published: March 2021

A relevância de práticas de formação para a leitura desde a infância e a intenção de concebê-las enquanto círculo virtuoso muitas vezes esbarra na intencionalidade das concepções educativas adultas, que transforma a vivência em um círculo tedioso para as crianças. As fenomenologias da voz, a partir de Paul Zumthor, e da imagem, com Gaston Bachelard, evidenciam o valor poético da vocalidade e da imaginação para a leitura, que se fundamenta na organicidade da ação poética da voz e da palavra adultas, através das quais, sem negar os valores de proferição e de explicação e não se restringindo a eles, sublinha a estreita ligação entre corpo, linguagem e mundo nos processos de formação, também a leitora. Assim, a escuta da leitura compartilhada se transforma não só em potência para engendrar desejo de ler e de escrever, mas em oportunidade para que as crianças encontrem, através da voz e do comprometimento adulto, a experiência do humano que temos produzido e exteriorizado em registros orais e escritos, inclusive os literários. A ideia de cultura percebida como um conteúdo – e condicionada aos limites da aprendizagem de conceitos –, restringe a contribuição que podemos dar às crianças para a constituição de outras maneiras de compreenderem o conhecimento, o que inclui, principalmente, saberes sobre os modos como compartilham suas experiências leitoras.
Educação infantil e a práxis psicanalítica
Authors: Fonseca Paula Fontana , Voltolini Rinaldo 
Published: March 2021

O presente artigo debate as políticas públicas em Educação Infantil tomando por operador de leitura a proposição dos discursos formulada por Lacan. Segundo esta teoria, cada discurso agencia uma política que lhe é própria, seguindo uma lógica que lhe é imposta estruturalmente. A isto se deu o nome de agenciamento discursivo, ou seja, uma dinâmica estrutural que antecede determinado dizer e que imprime uma direção inexorável ao mesmo. Os quatro discursos propostos pelo autor são: o da histérica, o do mestre, o do universitário e o do analista. A eles veio somar-se, posteriormente, o discurso do capitalista que guarda pontos de distinção com os quatro primeiros. Foram analisados os discursos presentes na educação infantil na atualidade de modo a demonstrar a preponderância da predição como lógica presente no âmbito das políticas públicas com efeitos na práxis educativa. Por fim, problematiza-se a participação da teoria psicanalítica como mais uma que dá subsídios à educação infantil e as consequências desta apropriação para a práxis do psicanalista que atua no campo educativo.
Integrated Real-Time Simulation in an Earth Model – Automating Drilling and Driving Efficiency
Authors: Arévalo Pedro J. , Hummes Olof , Forshaw Matthew 
Published: March 2021

Abstract
Real-time while drilling simulations use an evergreen digital twin of the well, consisting of physics-based models in an earth model to constantly update boundary conditions and parameters while drilling. The approach actively contributes to prediction or early detection of specific drilling issues, thus reducing drilling-related risk, non-productive time (NPT), and invisible-lost time (ILT). The method also unlocks further drilling optimization opportunities, while staying within a safe operative envelope that protects the wellbore.
In the planning phase, a run plan is prepared based on drilling engineering simulations – such as downhole hydraulics and Torque and Drag (T&D) – within the lithology and geomechanics of the earth model. While drilling, the run plan continuously evolves as automatic updates with actual drilling parameters refine the simulations. Smart triggering algorithms constantly monitor sensor data at surface and downhole, automatically updating the simulations. Drilling automation services consume the simulation results, shared across an aggregation layer, to predict drilling dysfunctions related to hole-cleaning, downhole pressure, tripping velocity (which might lead to fractured formations or formation fluids entering the wellbore), tight hole and pipe sticking. Drillers receive actionable information, and drilling automation applications are equipped to control specific drilling processes.
Case studies from drilling runs in the North Sea and in Middle East confirm the effectiveness of the approach. Deployment on these runs used a modular and scalable system architecture to allow seamless integration of all components (surface data acquisition, drilling engineering simulations, and monitoring applications). As designed, the system allows the integration of new services, and different data providers and consumers.
Training an Automated Directional Drilling Agent with Deep Reinforcement Learning in a Simulated Environment
Authors: Yu Yingwei , Chen Wei , Liu Qiuhua , Chau Minh , Vesselinov Velizar , Meehan Richard 
Published: March 2021

Abstract
Drilling a directional well becomes an essential process in the oil and gas industry to ensure better reservoir exposure and less wellbore collision risk. In the high-volume drilling market, cost-effective mud motors are dominant. The motor is capable of delivering the desired well curvature by switching between rotating and sliding operations. Therefore, to follow a predefined well trajectory, it is a critical mission to determine the optimal operation control sequence of the motor. In this paper, a method of training an automatic agent for motor directional drilling using the deep reinforcement learning approach is proposed.
In designing the method, motor-based directional drilling is framed into the reinforcement learning with an automatic drilling system, also known as an agent, interacting with an environment (i.e., formations, wellbore geometry, equipment) through choices of controls in a sequence. The agent perceives the states such as inclination, MD, TVD at survey points and the planned trajectories from the environment, and then decides the best action of sliding or rotating to achieve the maximum total rewards. The environment is affected by the agent's actions and returns corresponding rewards to the agent. The rewards can be positive (such as drilling to target) or negative (such as offset distance to the planned trajectory, cost of drilling, and action switching).
To train our agent, currently, a drilling simulator in a simulated environment is created with layered earth model and BHA directional responses in layers. Other attributes of the drilling system are assumed to be constant and handled automatically by the simulator. The planned trajectory is also provided to the agent while training.
The directional-drilling agent is trained for thousands of episodes. As a result, the agent can successfully drill to target in this simulated environment through the decisions of sliding and rotating. The proposed workflow is known as the first automated directional drilling method based on deep reinforcement learning, which makes a sequence of decisions of rotating and sliding actions to follow a planned trajectory.
Trapped in a Vicious Cycle of Violence: A Qualitative Inquiry Into The Experiences of HIV Serodiscordant Married Couples
Authors: larki Mona , Bahri Narjes , Roudsari Robab Latifnejad 
Published: March 2021

Abstract
Background: Violence against women is a major, complex, multidimensional and widespread public health concern worldwide. The current qualitative study was conducted to understand the experience of violence among HIV negative women in serodiscordant relationships.Methods: A qualitative description (QD) was conducted from October 2018 to January 2020 (16-month period) in Mashhad, Iran. The researchers recruited 15 HIV negative women who lived with HIV positive men through purposive sampling method. The data were collected using semi-structured interviews. Data analyzed using conventional content analysis adopted by Graneheim and Lundman (2004). Results: The main overarching theme emerged entitled: trapped in a vicious cycle of violence. It consisted of four categories of self-directed violence, intimate partner violence, cultural violence and structural violence. The cycle of violence began soon after awareness of husband's infection with acts such as suicide attempts and a sense of abhorrence for living with an infected person, and continued with confrontation with various types of violence in the family and society.Conclusions: This study provided an insight into different aspects of violence in Iranian women in HIV serodiscordant relationships. Healthcare providers should be able to address topics related to the violence for women who are in HIV serodiscordant relationships.
Metallated Anticancer Peptides: An Expanded Mechanism that Encompasses Physical and Chemical Bilayer Disruption
Authors: Comert Fatih , Heinrich Frank , Chowdhury Ananda , Schoeneck Mason , Darling Caitlin , Anderson Kyle W. , Libardo M. Daben J. , Angeles-Boza Alfredo M. , Silin Vitalii , Cotten Myriam L. , Mihailescu Mihaela 
Published: March 2021

Abstract
In the search for novel broad-spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing interest. Characterizing their biologically-active conformations and minimum motifs for function represents a requisite step to developing them into efficacious and safe therapeutics. Here, we demonstrate that metallating HDPs is an effective chemical strategy to improve their cytotoxicity on cancer cells. Mechanistically, we find that the metallated peptides not only physically but also chemically damage lipid membranes. Our testing ground features piscidins 1 and 3 (P1/3), two amphipathic, histidine-rich, membrane-interacting, and cell-penetrating HDPs that are α-helical bound to membranes. To investigate their membrane location, permeabilization effects, and lipid-oxidation capability, we employ neutron reflectometry, impedance spectroscopy, neutron diffraction, and UV spectroscopy. While P1-apo is more potent than P3-apo, metallation boosts their cytotoxicities by up to two-and seven-fold, respectively. Remarkably, P3 is particularly effective at inserting its metallated motif in bilayers, causing water crevices in the hydrocarbon region and placing Cu 2+ near the double bonds of the acyl chains, as needed to oxidize them. This study points at a new paradigm where metallating HDPs to expand their mechanistic reach could be explored to design more potent peptide-based anticancer therapeutics.
Cpne3 Regulates the Cell Proliferation and Apoptosis in Human Gbm via the Activation of Pi3k/akt Signaling Pathway
Authors: Zhang Dainan , Wang Xiaoyin , Wang Xi , Wang Zemin , Ma Shunchang , Zhang Chuanbao , Li Shaomin , Jia Wang 
Published: March 2021

Abstract
Background: Even with decades of intensive study, the signaling regulative network of the progression of GBM remains unclear, a deeper understanding of the molecular crosstalk with pathways in GBM is needed to identify new potential targets for treatment. Methods: To investigated the expression of CPNE3 in GBM, we applied bioinformatic analysis and clinical samples validation. Then the functional validation of carried out in commercially available glioma cell lines and nude mice model. Also, the GSEA analysis was used to identify the relevant pathways. The role of activated pathway was further validated by pharmacology method.Results: We found that CPNE3 was significantly up-regulated in GBM when compared with adjacent normal tissues, and the overexpression of CPNE3 promoted cell proliferation and inhibiting cell apoptosis in vitro and in vivo. Also, the principal protein markers of PI3K/AKT pathway were found to be phosphorylated by CPNE3 over-expression, and pathway inhibitor, LY294002, alleviated the cell proliferation enhancement induced by CPNE3 over-expression. Conclusion: Our results showed that the expression of CPNE3 promotes cell proliferation by inhibiting cell apoptosis via activating PI3K/AKT pathway, thereby enhancing the progression of GBM, which suggesting that CPNE3 may play as a tumorigenesis gene and its crosstalk with PI3K/AKT pathway may become a promising potential therapeutic target for human GBMs.
Intravaginal Non-Ablative Radiofrequency In The Treatment Of Genitourinary Syndrome Of Menopausesymptoms: A Phase I Clinical Trial
Authors: Pinheiro Cintia , Alencar Teresa , Amorim Raira , Campos Raquel , Brim Rosa , Teles Alcina , Queiroz Andrea , Lordelo Patrícia 
Published: March 2021

Abstract
Background: Genitourinary Syndrome of Menopause (GSM) involves vaginal dryness, dyspareunia, itching, burning, pain, and also symptoms in urinary organs. Non-ablative radiofrequency (RF) is a type of current with electromagnetic waves with the thermal effect that generates an acute inflammatory process with consequent neocolagenesis and neoelastogenesis. We aimed to describe the clinical response, cytological changes, and adverse effects of applying nonablative RF in patients with GSM and to assess sexual and urinary function after treatment. Methods: This is a pilot study with 11 women diagnosed with GSM with established menopause. Patients with hormone replacement initiation less than six months, who used a pacemaker or had metals in the pelvic region, were excluded. Subjective measures (Visual Numerical Scale-VNS of symptoms, Vaginal Health Index-VHI) and objective measures (Vaginal Maturation Index-VMI and vaginal pH) were used. Sexual function was assessed by the FSFI, and the ICIQ-SF measured the impact on urinary function. A Likert scale measured the degree of satisfaction with the treatment. Five sessions of monopolar non-ablative RF (41 °C) were performed with an interval of one week between each application. The entire evaluation was performed before treatment (T0), one month (T1), and three months (T2) after treatment. Adverse effects were assessed weekly. Results: There was a reduction in symptoms after treatment in most patients (T1/T2, respectively): vaginal dryness 90.9%/81.8%, dyspareunia 83.3%/66.7, vaginal laxity 100%/100%, pruritus 100%/100%, burning 75%/87.5%, pain 75%/75%, and in VHI 90.9%/81.9%. Most patients did not show changes in VMI (54.5%) and pH (63.6%) at T1, but there was an improvement in VMI in most patients (54.5%) at T2. Nine patients were satisfied and two were very satisfied at T1. The treatment was well tolerated and no adverse effects were observed. There was an improvement in sexual function in 72.7% and in urinary function in 66.7% in T1 and 83.3% in T2. Conclusion: Intravaginal RF reduced the clinical signs and symptoms of GSM and women reported satisfaction with treatment. The technique showed no adverse effects and there were positive effects on sexual and urinary function. Trial registration: This research was registered at clinicaltrial.gov (NCT03506594) and complete registration date (first date posted) April 24, 2018.
The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis
Authors: Ehtesham Naeim , Rafie Maryam Zare , Mosallaei Meysam 
Published: March 2021

Abstract
Background: Considering that familial multiple sclerosis (FMS) can reveal the extent to which genetic and environmental factors each involve in the etiopathogenesis of the disease, we performed an updated meta-analysis of the worldwide prevalence of FMS by addition of recent publications. Methods: A search in PubMed, Scopus, the ISI Web of Science, and Google Scholar up to 20 December 2020 was done. The inclusion criteria were based on the CoCoPop approach (condition, context, and population). The qualified studies entered the process of the meta-analysis by using comprehensive meta-analysis ver. 2 software.Results: The pooled prevalence of MS in relatives of 16179 FMS cases was estimated to be 11.8% (95% CI: 10.7-13) based on a random-effects model. The pooled mean age of disease onset in adult probands was calculated to be 28.7 years (95% CI: 27.2± 30.2). In 13 studies that reported the data of FMS in pediatrics (n=6636) and adults (n=877), the FMS prevalence was 10.8% (95% CI: 8.1-14.2) and 15.5% (95% CI: 13.8-17.4), respectively. Considering the data of 9 studies, the prevalence of FMS in males (n=5243) and females (n=11503) patients was calculated to be 13.7% (95% CI: 10.1-18.2) and 15.4% (95% CI: 10.3-22.4), respectively. The odds ratio of male/female in FMS cases was not statistically significant (OR= 0.9; 95% CI: 0.6-1.2, P=0.55). Subgroup analysis demonstrated a significant difference in the prevalence of FMS between the geographical areas (P= 0.007). The meta-regression model for FMS prevalence was significantly lower in terms of higher latitude (P< 0.001) and increased MS prevalence (P< 0.001). In contrast, meta-regression based on prevalence day was not statistically significant (P=0.29).Conclusions: The prevalence of FMS is more in the pediatric group than that of adults, is distinct between geographical areas, and diminishes with the increment of MS prevalence and latitude. Also, the symptoms initiate relatively at lower ages in FMS cases. By contrast with multifactorial diseases, our analysis unveiled that the prevalence of FMS was not more prevalent in men than women and the risk of MS development in relatives was not more when the affected proband was male.