bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the effects of reservoir impoundment on phytoplankton and shoreline vegetation communities using the space-time substitution method
Authors: Xu Guoxin , Ge Zhengkui , Wang Qi , Pan Baozhu , Li Ming 
Published: May 2021

Abstract
The prediction of the influence of reservoir impoundment on water quality and phytoplankton community is the basis of ecological compensation or restoration. The aim of the current study was to predict the effects of reservoir impoundment on phytoplankton and shoreline vegetation communities using the space-time substitution method. The Huangjinxia Reservoir under construction on the Han River was selected as the research object. The space-time substitution method indicated that the average values of the total phosphorus (TP) and ammonia (NH4+-N) increased from 0.049 and 0.279 mg L−1 to 0.139 and 1.132 mg L−1, respectively, after reservoir impoundment. The percentage of diatom biomass exceeded 95% before the reservoir impoundment. However, it was gradually decreased to 75% after the reservoir impoundment. Meanwhile, the biomass of Chlorophyta, Cryptophyta and Pyrrophyta increased significantly, accounting for 32, 20 and 13% of the total biomass, respectively, after reservoir impoundment. Cynodon dactylon (65.3%), Polygonum hydropiper (51.7%) and Aster subulatus (50.3%) were the dominant shoreline vegetation before the reservoir impoundment, whereas after the reservoir impoundment, the dominant species shifted to Alternanthera philoxeroides (62.3%), Lobelia chinensis (55.7%) and C. dactylon (53.9%). Our results suggested that the percentage of bloom-forming phytoplankton would gradually increase after the reservoir impoundment. In addition, A. philoxeroides, C. dactylon and L. chinensis would be the plants suitable for living in the shoreline of reservoirs in this area.
Specifically targeting Mtb cell-wall and TMM transporter: the development of MmpL3 inhibitors
Authors: Luo Qing , Duan Huaichuan , Yan Hailian , Liu Xinyu , Peng Lianxin , Hu Yichen , Liu Wei , Liang Li , Shi Hubing , Zhao Gang , Hu Jianping 
Published: May 2021

:
Tuberculosis (TB) remains a serious threat to whole human health. In particular, the drug resistance of Mycobacterium tuberculosis (Mtb) has become a huge challenge in clinical medicine, and it is extremely urgent to develop effective inhibitors with novel structures and mechanisms. Belonging to the Resistance, Nodulation and Division (RND) superfamily, Mycobacterial membrane proteins Large 3 (MmpL3) is mainly responsible for transporting mycolic acid outside cell membrane to form cell wall, and plays critical roles in iron acquisition which is vital to the survival of Mtb. As a potential Mtb target in recent years, its inhibitor research has attracted wide attention. A series of inhibitors (such as SQ109, AU1235, BM212, etc.) through experimental screening have been reported in succession, especially SQ109 has entered the clinical stage. In this paper, the structural biology information of target MmpL3 was summarized, and the structure-activity relationship (SAR) of inhibitors reported in recent years and their inhibitory mechanism both were reviewed, aiming to provide help for the rational design of MmpL3 inhibitors in the future.
Assessment of Medical Students’ Knowledge of Lynch Syndrome Cancers,
Screening, and Prevention
Authors: Pothuri Bhavana , Brodsky Allison , Baumann Katherine 
Published: May 2021

Background:
Lynch syndrome accounts for 3% of newly diagnosed endometrial cancers
and colon cancers. Identifying patients with Lynch syndrome is fundamental to enable proper
screening and prevention of at-risk malignancies, along with encouraging cascade testing of family
members. We aimed to assess medical students' knowledge of Lynch syndrome-associated cancers
and screening and prevention measures to decrease malignancy risk in patients with Lynch syndrome.

Methods:
An anonymous, voluntary, multiple-choice survey was emailed to 14 medical schools
throughout the US to evaluate medical students’ knowledge of Lynch syndrome.

Results:
We surveyed 342 medical students, and 65% were third or fourth-year medical students.
Ninety-three percent knew that colon cancer is one of two most commonly diagnosed cancers in
Lynch syndrome; however, only 37% knew endometrial cancer was the other most common malignancy
in Lynch syndrome patients. Fifty-nine percent of students recognized that 2-5% of all newly
diagnosed endometrial and colon cancers are due to Lynch syndrome. Ninety-one percent recognized
a family history that would indicate evaluation for Lynch syndrome, but only 49% knew that
all patients diagnosed with endometrial cancer prior to age 50 should be evaluated for Lynch syndrome
as per the National Comprehensive Cancer Network guidelines regardless of other risk factors.

Conclusion:
Almost two-thirds of medical students did not recognize endometrial cancer as a common
Lynch syndrome malignancy and less than 50% were aware of when to evaluate patients with
endometrial cancer for Lynch syndrome; comparatively almost all students recognized the link between
colon cancer and Lynch syndrome. Curriculum change with targeted education regarding endometrial
cancer and Lynch syndrome during medical school obstetrics and gynecology clinical rotations
should be implemented. This call to action is critical in improving the diagnosis of Lynch
syndrome, evaluation, screening, and prevention of cancers in both patients and family members to
reduce mortality.
Implementation of Quality by Design Principles for the Evolution of Optimized Sustained Release Drug Delivery System
Authors: Singh Lalit , Sharma Vijay 
Published: May 2021

Aim:
The aim of the present work is the implementation of Quality by Design principles
for the evolution of optimized sustained release drug delivery system.

Background:
Quality by Design (QbD) approach refers to an advance approach to develop an optimized
dosage form. QbD has become a vital modern scientific approach to develop a quality
dosage form. In the modern era of science, researchers can develop an optimized dosage form with
least effort, money and manpower.

Objectives:
Objective of the research work was the successful development of optimized floating
bioadhesive tablets of glipizide using floating-bioadhesive potential of cellulosic polymer and carbomersusing
quality by design (QbD) approach.

Methods:
Quality Target Product Profile (QTPP) of drug delivery system was defined as well as
critical quality attributes (CQAs) were identified. A face centered central composite design (CCD)
was utilized in assessing the impact of the individual critical material attribute (CMA) like Hydro
Propyl Methyl Cellulose K4M(HPMC K4M)and Carbopol 934P (CP 934P) and their interactions,
using least experimentation. Formulations were developed and quantitative impact on CQAs was
determined using mathematical model. The optimized formulation was obtained and characterized
for in-vitro as well as in-vivo parameters.

Results:
A Fishikawa diagram and Failure Mode and Effect Analysis (FMEA) was performed to
identify potential failure modes associated with the dosage form. The optimum formulation was
embarked upon using mathematical model developed yielding desired CQAs followed for confirmation
of data. Sustained release drug delivery system was successfully developed by using QbD
approach. In-vivo X-ray imaging in rabbit and γ-scintigraphic study in manconfirmed the buoyant
nature of the mucoadhesive floating tablet for 8 h in the upper gastrointestinal tract.

Conclusion:
Optimized formulation shows phenomenal floating, bioadhesive properties and drug
release retardation characteristics, utilizing a mixture of cost-effective polymers Hence, QbD approach
may be regarded as an important tool in development of floating bioadhesive CR dosage
forms.
Prototipe Pengaman Pintu Rumah Menggunakan Voice Recognition dengan EasyVR Berbasis Mikrokontroler
Authors: Ulum Syaeful , Budiyanto Maun 
Published: May 2021

The adventages of technology make every job easier, but this ease sometimes isn’t matched by safety factors. Security is vital to avoiding this technology being misused by uninvited people.This journal discusses the security of home doors with a microcontroller-based voice. The voice recognition process starts from the sound that propagates and then processes the corresponding easyvr sensor so that the easyvr sends a command to the relay to open the doorlock solenoid. From various tests obtained from voice recognition that can support the sound in the form of recordings, in speech recognition with an achievement level of 45 dB approved sound with an ideal pitch at 0-700 cm, it needs 75 dB sound amplifier with an ideal distance of 0-20 cm. For the percentage of success range with 30-40% different and the percentage of sound success is above 90%.Kemajuan teknologi membuat pekerjaan menjadi mudah, namun kemudahan tersebut tidak diimbangi dengan faktor keamanan. Keamanan menjadi hal yang vital untuk menghindari teknologi tersebut tidak disalahgunakan oleh orang yang tidak berwenang. Pada jurnal ini membahas pengaman pintu rumah dengan pengenalan suara berbasis mikrokontroler. Proses pengenalan suara dimulai dari suara yang merambat lalu diproses sensor easyvr jika sesuai sampling maka easyvr mengirimkan perintah kepada relay untuk membuka solenoid doorlock. Dari berbagai pengujian didapatkan bahwa pengenalan suara tidak dapat mengenali suara dalam bentuk rekaman, pada pengenalan suara dengan tingkat kebisingan 45 dB mengenali suara dengan ideal pada jark 0-700 cm, kebisingan 75 dB mengenali suara dengan ideal pada jarak 0-20 cm. Tingkat persentase keberhasilan suara yang berbeda 30-40% dan persentase keberhasilan suara yang sama diatas 90%.
Meals, Art and Meaning
Authors: John Eileen 
Published: May 2021

This paper takes meals, rather than food itself, as its focus. Meals incorporate the project of nutrition into human life, but it is a contingent matter that we nourish ourselves in this way. This paper defends the importance of meals as meaning-makers and contrasts them with art in that regard. Meals and art represent interestingly different extremes with respect to how needs for meaning are met. Artworks ask for coordination of experience, understanding and appreciation: the meaning of art is to be experienced. The meaning of meals is enacted and accumulates collectively, but need not be experienced.
Respiratory Stress of Sub-Lethal Concentration of Chlorine on Oreochromis niloticus
Authors: Asna Salam  , A.U.Arun  , Shalu Soman  
Published: May 2021

In aquatic environment, one of the most significant manifestations of the toxic stress on aquatic organisms, especially fishes are the over stimulation or depression of respiratory activities. These variations in respiratory activities have been used as in indicator of environmental stress. This study was aimed to assess the sub-lethal toxicity of chlorine through respiratory stress on Oreochromis niloticus. It was noticed that in all dosage experiments as the concentration increased rate of gill movement decreased. The rate of gill movement during the first minute after the dosage in control was 128 per minute. Serial dilution method employed in this study helped to assess the LC50 of chlorine and the value noted was 2 ppm. The minimum number of gill movement noted was in 20ppm dosage and the value was 98 per minute whereas the maximum noted was in 5ppm dosage and the value was 101 per minute. In 60th minutes after dosage also the control showed a value of 126 per minute and 20 ppm dosage showed a very low value such as 32 per minute whereas 5ppm dosage of chlorine showed a reasonably good value of 61 per minute. It was noted that in the case of average gill movement, control showed a very high value such as 127 per minute, whereas 5ppm dosage of chlorine showed a reasonably good value such as 84 per minute, and 20 ppm dosage showed a low value 72 per minute. When a comparison was made between control and differently dosed fishes, it was observed that in all dosed cases the average gill movement was very low when compared with control. A significant difference exists between gill movement in the dosed group and control (P<0.05). Consumption of oxygen increased with an increase in dosage and decreased with increased period of exposure. In control the average oxygen consumption was 0.012 mg/ml/gm body weight, in 5ppm it was 0.014 mg/ml/gm body weight, in 10 ppm it was 0.0155 mg/ml/gm body weight, in 15 ppm it was 0.021 mg/ml/gm body weight and in 20ppm it was0.022 mg/ml/gm body weight.
Indigenous Medicinal Plants of Tripura used by the Folklore Practitioners for the Treatment of Bone Fractures
Authors: Gunamoni Das  , Anjan Kumar Sarma  , NitulJyoti Das  , Prasenjit Bhagawati  , R. K. Sharma  
Published: May 2021

Traditional medicine is the oldest form of medicine and modern medicine has its roots in it. The experienced folklore practitioners are very scientific in their approach and understand well the mind and body relationship. This has enabled them to treat their patients in an integrated and holistic manner. Indian system of medicine has identified around medicinal plants, of which 500 species are used in preparation of drug formulations. KiratDesh an ancient name of Tripura was well known as a land of hills and dates in the past and was very rich in flora and fauna diversity. Almost all the plants contain some chemical compounds that are beneficial to mankind and many of them are used for medicinal values. In Tripura, about 266 species have been found to have medicinal properties. Folklore practitioners of Tripura were studied for the use of indigenous medicinal plants in the treatment of bone fractures. They use a combination of herbal, physical and natural process for treatment. They know that natural resources that have nurtured the human race the secret of healing. Knowledge of Traditional medicine is like a family heirloom and is transferred by means of inheritance. This precious knowledge should be conserved and all of indigenous medicinal plants should be protected from unauthorized use for monetary gain. We recorded 23 numbers of wild indigenous medicinal plant species and formulations of 12 types of traditional medicine treatments for the cure of bone fractures. This is a preliminary study and there is more scope for further extensive research and documentation.
Pendampingan Penerapan Sistem Minapadi Dalam Upaya Peningkatan Pendapatan Kelompok Tani Di Desa Guci Kabupaten Lamongan
Authors: Badriyah Nurul , Tauhid Hidayat , Rasmawati DJ Yuni 
Published: May 2021

Perikanan budidaya saat ini menjadi tumpuan penting dalam menompang perekonoian masyarakat Indonesia, terutama bagi masyarakat yang memperoleh pendapatan dari budi daya ikan. Hal tersebut yang dialami oleh sebagian masyarakat di kabupaten lamongan khususnya di Desa Guci. Akan tetapi hasil budi daya ikan yang yang diperolah masih bersifat fluktuatif, hal ini disebabkan banyak faktor terutama pengetahuan warga tentang ilmu budi daya ikan yang masih dirasa kurang. Melihat dari luasnya lahan pertanian yang ada di Desa Guci serta banyaknya penduduk Desa Guci yang berprofesi sebagai petani, seharusnya potensi alam yang ada dalam hal ini lahan pertanian bisa diolah dengan semaksimal mungkin demi tercapainya kesejahteraan kelompok tani di Desa Guci. Akan tetapi selama ini masih kurangnya pengetahuan masyarakat Desa Guci terutama yang berprofesi sebagai petani memahami bagaimana cara pemanfaatan lahan yang ada. Karena lahan yang ada hampir seluruhnya hanya ditanami padi pada msim kemarau dan dibuat tambak ketika musim hujan telah tiba. ikan yang dibudidayakan di tambaknya pun terbatas jenisnya yakni udang, ikan bandeng, ikan mujair dan kadang kala ikan lele. Tahap sosialisasi dilaksanakan di tempat mitra yaitu Kelompok Tani sebagai penghasil beras organik di Desa Guci Kabupaten Lamongan. Sosialisasi tersebut akan dilakukan secara intensif kepada beliau mulai dari instalasi alat, pengoperasian alat dan pemeliharaan alat. Selain itu strategi manajemen pemasaran juga disosialisasikan kepada Kelompok Tani mengingat beras organik akan dipasarkan secara meluas. Setelah kegiatan tersebut dilaksanakan, perlu diadakan monitoring untuk memantau kemajuan dari kegiatan yang telah dilakukan baik dari segi teknologi pengemasan maupun pemasaran.
Optimalisasi Pengembangan Produk Unggulan Desa (OVOP) Melalui Wawasan Kewirausahaan Dan Pembuatan Laporan Keuangan Sederhana Bagi UMKM
Authors: Nurhayati Neni 
Published: May 2021

Besarnya potensi UMKM ternyata tidak serta merta menyebabkan UMKM mampu mengembangkan potensi usahanya. Kendala utama yang sering muncul adalah keterbatasan modal yang dimiliki serta kesulitan dalam memperoleh akses sumber permodalan misalnya ke perbankan dan sumber pembiayaan lainnya. Rendahnya kualitas sumber daya manusia yang dimiliki UMKM membuat mereka sering terjebak dengan sumber-sumber dana informal, yang sekali lagi disebabkan oleh kerumitan persyaratan pemenuhan dana yang bersumber dari sektor keuangan formal. Salah satu dari persyaratan yang paling sulit untuk dilengkapi adalah persyaratan untuk melampirkan laporan keuangan usaha. Kemudahan akses modal perbankan dapat diperoleh apabila para pelaku UMKM dapat memberikan rincian informasi mengenai keadaan usaha UMKM yang tercermin pada laporan keuangannnya. Peraturan Pemerintah RI No 17 Tahun 2013 tentang pelaksanaan UU No 20 tahun 2008 menyatakan adanya kewajiban bagi usaha kecil untuk melakukan pencatatan akuntansi. Namun demikian, adanya peraturan tersebut tidak serta merta membuat pelaku UMKM melakukan pencatatan dikarenakan berbagai keterbatasan. Tujuan pelaksanaan pengabdian kepada masyarakat ini adalah untuk memberikan pemahaman, pengetahuan dan wawasan mengenai berwirausaha dengan mengembangkan potensi desa serta memberikan pendampingan dalam implementasi sistem pencatatan akuntansi manual dengan melakukan aktivitas pembuatan laporan keungan sederhana untuk memberikan kemudahan mendapatkan akses permodalan dari perbankan. Metode pengabdian yang digunakan yaitu ceramah, workshop, praktik, dan evaluasi kegiatan. Hasil dari pengabdian kepada masyarakat ini berupa pengembangan produk unggulan desa (OVOP) dan keterampilan pembuatan laporan keuangan sederhana.
Legalitas Badan Usaha Pada Masyarakat Desa Daratan Kempas Kecamatan Tebing Tinggi Kabupaten Tanjungjabung Barat Dalam Rangka Peningkatan Ekonomi Kreatif
Authors: Yetniwati Yetniwati , Yahya Taufik , Amir Diana 
Published: May 2021

Penyuluhan hukum dilaksanakan adalah untuk menambah pengetahuan dan wawasan masyarakat sasaran. Adapun tujuan penyuluhan ini adalah: 1. untuk memberikan gagasan, dan pemahaman masyarakat tentang persyaratan melegalitas suatu badan usaha; 2. untuk memberikan gagasan, dan pemahaman masyarakat tentang proses melegalitas suatu badan usaha. Sebelum penyampaian materi terlebih dahulu dilakukan survey awal terhadap 25 orang masyarakat sasaran. Metode pelaksanaan dengan melakukan ceramah, tanya jawab. Hasil survey awal, sebelum dilaksana penyampaian materi hasil survei menunjukan bahwa pengetahuan masyarakat tentang legalitas badan usaha sangat kurang sekali dari 12 pertanyaan yang diajukan pada kuisioner . Pengukuran penambahan tingkat pengetahuan masyarakat sasaran dilakukan dengan melakukan survei ulang dengan mengedarkan kuisioner yang sama kembali. Setelah dilakukan penyampaian materi penyuluhan berupa pengertian, jenis, persyaratan dan prosedur mendirikan badan usaha, ditemukan 80 % dari materi penyuluhan dapat dipahami masyarakat sasaran. Akhirnya masyarakat berminat untuk mendaftarkan merek usaha dan berencana akan mendirikan Perseroan Terbatas , hal ini nanti tergantung pada kondisi keuangan masyarakat.
Pengembangan UMKM Kerajinan Anyaman Untuk Meningkatkan Perekonomian Masyarakat Desa Sumberjo Kecamatan Sarirejo Kabupaten Lamongan
Authors: Fibriyanti Yenni Vera , Zulyanti Noer Rafikah , Alfiani Alfiani 
Published: May 2021

Pembuatan kerajinan anyaman di Desa Sumberjo, Kecamatan Lamongan, Kabupaten Lamongan mempunyai peran dalam meningkatkan perekonomian masyarakat. Namun di sisi lain, terdapat permasalahan dalam mengembangkannya yaitu kurangnya keterampilan dan ketelatenan dalam membuat kerajinan anyaman. Masyarakat Desa Sumberjo banyak yang berprofesi sebagai petani atau buruh tani. Demikian pula dengan pemuda Desa Sumberjo, mereka banyak memilih bekerja di luar kota. Penelitian ini menggunakan metode kualitatif yang ditekankan pada jenis deskriptif kualitatif. Teknik pengumpulan data yang digunakan adalah focus group discussion. Hasil yang telah dicapai dalam pelaksanaan pelatihan pengembangan UMKM kerajinan anyaman yaitu (1) meningkatnyaketrampilan pengrajin anyaman dalam membuat produk anyaman bambu dan anyaman tikar; (2) meningkatnya daya saing produksi kerajinan anyaman; (3) meningkatnya perekonomian masyarakat Desa Sumberjo, Kecamatan Sarirejo, Kabupaten Lamongan melalui pembuatan laporan keuangan UMKM.
Pemanfaatan Hasil Perikanan Dalam Bentuk Olahan Daging Ikan Nila Menjadi Nugget Dalam Rangka Diversifikasi Pangan pada Warga RT 07 Desa Kedotan, Kecamatan Sekernan, Kabupaten Muaro Jambi
Authors: Indriyani Indriyani , Rahmi Silvi Leila , Wulansari Dian , Mursyid Mursyid , Rahmayani Irma 
Published: May 2021

Desa Kedotan yang berada di Kecamatan Sekernan, Kabupaten Muaro Jambi merupakan salah satu desa penghasil ikan nila di Provinsi Jambi. Produksi ikan nila dari daerah ini biasanya hanya dijual dalam bentuk ikan nila segar, dan masih sangat jarang ditemui dalam bentuk olahan. Penganekaragaman produk olahan ikan memiliki keunggulan diantaranya masa simpan yang lama sehingga dapat menjadi alternatif dalam meningkatkan total konsumsi sumber bahan pangan hewani. Selain itu, dapat membantu meningkatkan pendapatan warga desa terutama disaat pandemi corona yang sedang terjadi saat ini untuk dijadikan usaha. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pelatihan dan pembinaan kepada masyarakat terkait pemanfaatan potensi daerah yang memiliki nilai jual ekonomis. Adapun bentuk pelatihan yang diberikan adalah pelatihan pengolahan daging ikan nila menjadi produk nugget ikan. Kegiatan pengabdian kepada masyarakat yang dilakukan berlangsung lancar dan baik. Kegiatan ini disambut hangat dan penuh antusias oleh masyarakat terutama ibu-ibu yang berada di Desa Kedotan. Melalui kegiatan ini, diharapkan masyarakat Desa Kedotan tertarik untuk membentuk kelompok usaha produktif berskala UMKM sehingga menambah penghasilan keluarga.
Pemberdayaan Masyarakat Melalui Pelatihan Pengolahan Sayuran Menjadi Selai Dengan Metode Atmospheric Sebagai Alternatif Usaha Keluarga Di Kelurahan Rajawali Jambi
Authors: Sari Novita , Chairunnisa Fitri , Rosmeli Rosmeli 
Published: May 2021

Kelurahan Rajawali adalah salah satu dari sembilan kelurahan yang ada di Kecamatan Jambi Timur, dengan luas wilayah 31.060 Ha dan jumlah penduduk sebanyak 8.441 jiwa. Dari total jumlah penduduk, sekitar 60% sudah memiliki mata pencaharian dengan berbagai tingkat penghasilan. Hanya 33 % warga yang berusia diatas 15 tahun, dimana 17 % masih berada di usia sekolah dan sisanya berada di usia produktif. Jumlah penduduk terbanyak di kelurahan ini adalah perempuan, yaitu sebanyak 4.304 jiwa atau 51 % dari total penduduk yang ada, sedangkan jumlah penduduk laki – laki adalah sebanyak 4.107 jiwa atau 49 % dengan jumlah KK sebanyak 2.061 KK.