bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study between Ivabradine Versus Bisoprolol Effects for Heart Rate Control on Hemodynamics and Clinical Outcomes in Patients with Septic Shock
Authors: El-Miseery Omnia Ali , Elashry Hesham Elsaid , Elbably Magdy Elsaid , Elbably Magdy Elsaid , Hamed Ahmed Mohammed 
Published: June 2021

Background: Septic shock is associated with excessive sympathetic outflow, high plasma catecholamine levels, myocardial depression, vascular hypo-reactivity, and autonomic dysfunction. Typically, patients have a low resistance, high cardiac output circulation with tachycardia and arterial hypotension that may be poorly or even nonresponsive to exogenous catecholamine vasopressors. The aim of the present study was to compare the effect of ivabradine vs bisoprolol for heart rate control on the hemodynamics and clinical outcomes in patients with septic shock.
Methods: The study was carried out on 90 patients, aging from 18 to 60 years of both sex presented with septic shock in ICU. Patients were randomly classified into 3 equal groups each of 30 patients. Group I (Control group) received conventional therapy. Group II (Bisoprolol group) received conventional therapy plus bisoprolol 5 mg once daily & one placebo pill on 12 hrs interval via nasogastric tube for 7 days. Group III (Ivabradine group) received conventional therapy plus ivabradine 5 mg twice daily on 12 hrs interval via nasogastric tube for 7 days.
Results: Both bisoprolol and ivabradine effectively lowered heart rate in septic shock patients but ivabradine was more effective than bisoprolol. Both bisoprolol and ivabradine did not affect mean blood pressure, with ivabradine being more effective in maintaining blood pressure than bisoprolol. Noradrenaline dose was lower in ivabradine group in comparison with the other two groups. As regard to stroke volume & cardiac output, there was improvement in ivabradine group in comparison with bisoprolol and control groups. As regard to serum lactate level, there was improvement in ivabradine group in comparison with the other two groups. Both bisoprolol & ivabradine resulted in reduction in LOS & 28-day mortality with no significant difference between both groups.
Conclusions: Controlling heart rate in septic shock patients with either bisoprolol or ivabradine improves outcomes. Ivabradine is better than bisoprolol in maintaining hemodynamics and improving tissue perfusion parameters.
An Autopsy Study of the Quantitative Anatomy of Human Heart
Authors: Raveendran S. , Vidanapathirana M. , Hulathduwa S. R. 
Published: June 2021

There is no uniformity in obtaining anthropological measurements of the heart. Measurementsvary according to the methods used by different authors. The normality standard for organ weights should be established in a specific reference sample for each population, as the normality values can be different under genetic and environmental influences. This study is aimed to determine the average values of quantitative anatomy of the adult heart for the Sri Lanka population using autopsy data with an attempt to determine the relationship with sociodemographic factors such as the body weight, age, gender and the body length. Designed as a descriptive cross-sectional prospective study, it was performed on fresh (unfixed) adult hearts recovered at medico-legal autopsy on deaths due to non-cardiac natural causes and miscellaneous unnatural causes for a period of one year. Systematic consecutive sampling method was used from September 2018 to September 2019. Only 122 samples (68 males and 54 females) were included from among 282 adult hearts collected during this period due to strict inclusion and exclusion criteria. Average weight of the heart, thicknesses of the inter-ventricular septum, free wall of the left ventricle and right ventricle for males and females were 296.1 g, 236.85 g, 9.71 mm, 9.52 mm, 1.28 cm, 1.19 cm and 3.41mm, 3.02mm respectively. Male heart weight, interventricular septal thickness and other findings were compatible with contemporary Eastern studies. Significant association was demonstrated in the wall thickness of right ventricle with gender (P- value being 0.038). Large scales multi centered studies to find out the normality standard for heart measurements in Sri Lankan population are recommended.
Effect of Vibratory Therapy in Decreasing the Vaccination-induced Pain in Infants: Randomized Controlled Study
Authors: Taksande Amar , Chaudhary Shruti , Panwar Abhilasha Singh , Jhamb Aditi , Rao Rupesh , Jameel Patel Zeeshan , Damke Sachin , Meshram Revat 
Published: June 2021

Background: Different non-medical therapies such as Non-nutritive sucking (NNS), oral sucrose with or without NNS (non-nutritive sucking), wrapping with thin blanket or cloth, kangaroo mother care (KMC), songs as well as multi-sensory stimulation are beneficial in pain reduction among neonates and infants. According to the gate control theory, vibrations applied sat a site on the body block the nociceptive signals via the A???? and C fibers reducing the pain perception. When used along with many other nonpharmacological methods, This technique has been shown to minimize discomfort in pain-inducing treatments such as Intravenous cannulation, vaccines, heel prick, etc. The primary purpose of this study is to analyze vibrational therapy effects on infants pain perception, thereby, providing evidence for a better pain management strategy in vaccination centers.
Objective: To determine the efficacy of vibration therapy on pain perception by infants during vaccine administration.
Material and Methods: Out of total 90 eligible healthy infants who come for routinely immunization will be given either vibrational therapy (interventional group) or breastfeeding(control therapy) after doing randomization in this randomized controlled trial. The baseline vitals include cardiac rate (HR), respiratory rate (RR), and oxygen (SpO2) will be recorded before, during, and after vaccination during this treatment. Similarly, we will report Visual analog scales (VAS), Neonatal Infant Pain Scale (NIPS), and Wong-Baker FACES Pain Rating Scale, Modified Behavioral Pain Scale (MBPS) after giving the vaccine to the infant.
Results: After completion of the study we will come to know the effect of vibratory therapy on pain control. The pain intensity with the help of the NIPS score will get less in the vibratory group than in the control group. The level of distress by using the Color Analogue Scale, MBPS scale, and FLACC scale, during the vaccine-related procedure will get a lower score in the infants who has taken vibratory therapy than the control group.
Conclusion: study will probably give us information about vibration therapy, which will be an effective method for managing the pain after vaccination in infants.
A Comparative Study between Conventional Sutures, Staples and Adhesive Glue for Clean Elective Surgical Skin Closure
Authors: Mastud Kiran , Lamture Y. R. , Yeola(Pate) Meenakshi 
Published: June 2021

Background: A surgeon's signature is 'scar' [1]. On a regular basis, surgeons face various kinds of wounds which must be healed. The healing process and cosmetic result can be influenced by wound and incision closure techniques.
The Goal of this Research is to Compare 3 Skin Closure Techniques: conventional skin sutures, adhesive glue, surgical stapler. These methods will be used to determine which of them is superior in terms of wound healing and cosmetic outcome in clean elective surgeries.
Objectives:

To compare duration between closure by 3 methods.
To compare prices amongst the 3 methods.
A comparison of the cosmetic appearances of the skin after closure.
A comparison of post-operative pain between the 3 methods.
To assess surgical site infections after closure with these 3 methods

Methodology: 90 patients, undergoing clean elective surgeries, will be included in this study. 30 patients will be included in every group. Hospitalised under Department of General Surgery in Datta Meghe Institute Of Medical Sciences, Wardha. The study will be conducted between October 2020 to October 2022.
Results: The result would be undertaken in SPSS software.
Conclusion: Conclusion will be based on findings of study protocol.
A Bibliometric Analysis of Pharmaceutical Sciences-Related Articles in Qatar from 2013-2020
Authors: Idoudi Sourour , Ibrahim Mohamed Izham Mohamed , Alali Feras , Billa Nashiru 
Published: June 2021

Backgrround: Pharmaceutical science is an important area in drug discovery and therapies.The research output generated from pharmaceutical sciences research is critical for psychological, physical, and social wellbeing.
This study was carried out to analyze Qatar's quantity and quality of pharmaceutical sciences-related research and map out a national research roadmap and priority areas.
Materials and Methods: A systematic search was carried out in the Web of Science, Scopus, Pub Med, and Google Scholar databases using the search terms “Pharmaceutical Science,” “Pharmaceutical Chemistry,” “Medicinal Chemistry,” “Pharmacology,” “Pharmaceutics,” “Pharmacokinetics,” “Physiology,” “Pharmaceutical Science research,” “Study,” other relevant terms related to Pharmaceutical Sciences field and “Qatar.”The search covered eight years. The data extracted included the title, keywords, publication date, authors, publishing journal, journal ranking, impact factor, type of article, number of citations, the sum of citations, H-index, etc.
Results: The search yielded123 studies. Most were original articles (n=100, 81.3%), published in 2019 (n=27, 22.0%), applied research (n=68, 55.3%),indexed in Web of Science (n=120, 97.6%),published under the subject of pharmacology (n=43, 42.6%), focused on cancer (n=46, 37.4%)and produced by five authors (n=19, 18.8%) and more than eight authors (n=19, 18.8%). Hamad Medical Corporation (HMC) was the main collaborator (n=16, 13.0%). Fifty-four (43.9%) of the articles were published in journals ranked as Q1.
Conclusions: A total of 123 articles were published, with an average annual growth rate of 6.7% in publications and 946 citations. A high number of publications were in Q1 and Q2 journals. The research focus (e.g., cancer and cardiovascular) was established according to the country’s research roadmap and priority areas.
Role of Green Tea on Obesity and Type-II Diabetes Mellitus Male Individuals
Authors: Shah Tazeen , Dars Saira , Sheikh Saima Ashfaque , Shaikh Farheen , Ansari Shafaq , Akhtar Naheed , Ahmer Arslan 
Published: June 2021

Objective: To evaluate the effects of Green tea on obesity and hyperglycemia.
Methodology: This observational study was carried out at the department of physiology, in affiliation to Medical Research Centre Liaquat University of Medical and Health Sciences Jamshoro. The sample was collected by convenient random sampling. Total 100 participants, 50 controls and 50 obese diabetics were enrolled. Informed written consent was taken from participants. The body mass index (BMI) of the participants was taken at the time of recruitment, and later at 16 weeks of consuming green tea. The serum glucose levels were assessed by fasting (FBS) and random blood sugar (RBS) levels, and HbA1C. The levels of serum Blood glucose were obtained with the glucose oxidase method. Data analysis was done on SPSS 21.0, analysis of variables was done by applying student t-test, the p-value of <0.05 was taken as statistically significant.
Results:100 participants recruited out of which 50 controls and 50 obese diabetics men, it was found that the prolong consumption of green tea for 16 weeks with 20-30 minutes’ walk had statistically significant declined in FBS, RBS, HbA1c, and BMI in the obese diabetic subjects, as compared to the controls.
Conclusion: This study concludes that the green tea has positive effect in reducing the total body weight and BMI and helps in maintaining the normoglycemic levels in Type 2 DM.
Enhancement of Solubility and Dissolution Rate of BCS Class-II Fluvoxamine Tablets using Solvent Evaporation Solid Dispersion Technique
Authors: Srinivas Martha , Singh Anoop 
Published: June 2021

Aim: This research work was aimed to formulate Enhancing the solubility of Poorly soluble drug i.e. Fluvoxamine tablets by the solvent evaporation method, Fluvoxamine medicament is a selective serotonin reuptake inhibitor (SSRI) antidepressant agent.
Purpose: The BCS class II drug Fluvoxamine consist low aqueous solubility and low oral bioavailability, for this reason to improve the biological performance of Fluvoxamine drug by solid dispersion mechanism.
Methodolgy: The drug Fluvoxamine was formulated by using solvent evaporation technique, solid dispersions of Fluvoxamine were prepared with different carriers in different ratios of PEG 6000 & Mannitol (1:1, 1:2 and 1:3).
Results: Results of prepared solid dispersions of Fluvoxamine by solid dispersion method Finally by comparing all the formulations, formulation (SF3) containing Fluvoxamine and PEG 6000 (1:3) shows better results.
Conclusion: Here we concluded that the poorly soluble drug solubility improving by solvent evaporation solid dispersion mechanism, and also developed six Fluvovamine formulations (FDF1-FDF6) during this FDF4 shows maximum (98.9±0.8%) drug release at the end of time.
Comparative Pharmaceutical Standardization and Oral Bioavailability Study on Praval Pishti and Praval Bhasma
Authors: Satpute Megha , Rathi Bharat , Wanjari Anita , Khan Mujahid 
Published: June 2021

Background: Praval (coral) is a very usually occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two formulas which are bhasma (calcinated ash) and pishti(powdered form without agni).These forms may have different rate of immersion. This needs to be studied.
Aim: Pharmaceutical Standardization study of Praval Pishti & Praval Bhasma and comparative evaluation of their relative oral bioavailability.
Materials and methods: The two formulations will be prepared from Praval (coral). By triturating with Gulab jala Praval Pishti will be prepared and by traditional Puta method Praval Bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, Physicochemical parameters and Particle size distribution analysis, SEM –EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), and GCMS (Gas Chromatography Mass Spectroscope) will be evaluated. To assess the relative oral bioavailability of Praval Pishti & Praval Bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement.
Observation and results: The study will be assessed for its relative oral bioavailability in healthy Volunteers by using unpaired “t” Test, One-way ANOVA.
Conclusion: The pharmaceutical study of Praval Bhasma and Praval Pishti will provide the standard parameters and comparative evaluation with standard will generate evidence for better bioavailability.
Hierarchically Porous Polymer and Carbon Monoliths via Controlled/Living Radical Polymerization
Authors: Kanamori Kazuyoshi , Hasegawa George , Nakanishi Kazuki 
Published: June 2021

Abstract
Cross‐linked monolithic polymer networks (or dried gels) with hierarchically porous structures have been prepared by controlled/living radical polymerization techniques such as nitroxide‐mediated radical polymerization (NMP), atom transfer radical polymerization (ATRP), and organotellurium‐mediated living radical polymerization (TERP). Well‐controllable macropores are formed as a transient structure of spinodal decomposition induced during the polymerization of monomers, and smaller pores in the macropore skeletons are resulted from secondary phase separation during the phase separation–gelation process. Also, the obtained networks are pyrolyzed in an inert atmosphere to obtain carbonaceous materials with abundant micropores while preserving the macro‐ and mesoporous morphology. In addition, applications of such hierarchically porous monolithic materials to separation media and electrochemical devices are demonstrated. In the present article, the concept, mechanism, methodology, and experimental results are discussed in detail.
Atomic Force Microscopy, Transmission Electron Microscopy, Scanning Electron Microscopy, and FourierTransform‐InfraredSpectroscopic Imaging as Tools to Study Various Phenomena Involving Poly(Vinylpyrrolidone)
Authors: McMullen Roger L. 
Published: June 2021

AbstractThis chapter examine state‐of‐the‐art advanced imaging techniques and how these tools can be used to study polymer blends and composites containing poly(vinylpyrrolidone) (PVP) and its derivatives. The imaging technologies discussed consist of many of the modes of atomic force microscopy as well as basic and advanced methods in transmission electron microscopy (TEM) and scanning electron microscopy (SEM). There are two principal types of electron microscopy, SEM and TEM. Both techniques provide different types of information about the sample under investigation. The chapter demonstrates the use of Fourier transform–infrared (FT‐IR) spectroscopic imaging to spatially map elements of multicomponent systems. FT‐IR spectroscopic imaging is a technique that involves the coupling of an FT‐IR spectrometer with an optical microscope. Powerful tool based on AFM and IR spectroscopy has become available to researchers. The chapter also demonstrates the use of imaging technologies to characterize PVP‐metal nanoparticle composites with a specific focus on silver and gold particles.
Development, Application and Future Trends of Pyrrolidone‐ and Caprolactam‐Based Materials in the Pharmaceutical Industry
Authors: Hood David K. , Ananthraman Srinivasan , Musa Osama M. 
Published: June 2021

AbstractThe initial success of polyvinylpyrrolidone (PVP) as a blood plasma expander in Europe and later in the United States led to further clinical investigation into the polymer's biological interactions. Pharmaceutical excipients constitute the majority ingredients of a medicine. The excipients, apart from meeting the stringent quality and safety requirements for medical usage, play a crucial role in ensuring stability and bioavailability of the active principles. Solubility and solubilization are important concepts in the pharmaceutical industry. The chapter presents the discussions on delivery of drugs by nanoparticles and amorphous solid dispersions cover aspects of molecular complex formation between drugs and pyrrolidone‐ or lactam‐based materials. Formulations based on povidone iodine continue to remain popular even decades after their first uses for wound healing and antisepsis. Stronger binding in the lower dendrimers may have utility in certain drug delivery situations, where complex stability coupled to drug delivery to the destination are deemed critical to the treatment situation.
Safety and Toxicology of Pyrrolidones and Pyrrolidone‐Based Polymers
Authors: Kim Sang‐Tae , Schatz Anthony , Choi Christopher 
Published: June 2021

Abstract
This chapter aims to summarize and communicate the best available information to enable assessments of human health hazard, exposure, and risks that are associated with pyrrolidone chemistries in their intended applications. The pyrrolidone family of chemicals are high‐production derivatives of oxo‐pyrrolidines. The pyrrolidone family of chemicals include 2‐pyrrolidone, N‐methyl pyrrolidone (NMP), N‐vinyl pyrrolidone, lauryl pyrrolidone, N‐octyl pyrrolidone, and hydroxy ethyl pyrrolidone. The toxicity of pyrrolidone chemistries has been reviewed and assessed by numerous human health and environmental agencies worldwide. Pyrrolidone‐based polymers are versatile ingredients used in the cosmetics and beauty industry as a binder, film former, emulsion stabilizer, suspending/viscosity increasing agent, and hair fixative. A number of chronic studies have been conducted to determine the carcinogenic potential of polyvinylpyrrolidone. Consumer exposure to NMP can occur via the use of paint strippers. NMP is readily biodegradable and should be degraded within the wastewater treatment process.
Personal and Home Care Applications of Pyrrolidone‐ and Caprolactam‐Based Materials
Authors: Rigoletto Raymond , McMullen Roger L. 
Published: June 2021

Abstract
The key ingredients making up the framework of the formula must perform in the constraints of the intended chemical environment, such as in the high surfactant load of a shampoo or the extremes of pH found in household cleaners. In order to fully explain the features and benefits of polymer treatments on human hair to achieve cosmetic effects, such as care, styling, and treatment, it is essential to first consider the nature of hair and the important facets of its behaviour. Polymer adhesion to the surface of hair is a prerequisite for its use as a hair styling polymer. The chapter describes the technologies in the home care market space that include poly(vinylpyrrolidone) (PVP), poly(vinyl caprolactam), and their derivatives. PVP and its derivatives have been formulated into laundry care products, such as liquid detergents, to counteract dye transfer. Molecular modeling was also used to show the importance of conformational interactions of dyes with PVP.
Toward a standardized statistical methodology comparing optimum nitrogen rates among management practices: A bootstrapping approach
Authors: Francis Hannah R. , Ma Ting Fung , Ruark Matthew D. 
Published: June 2021

AbstractThere are a range of approaches to compare differences between or among optimum nitrogen (N) fertilizer rates resulting from different management practices; however, this goal lacks statistical standardization. To provide the statistical rigor needed to give clear recommendations for greater or less N need based on specific management practices, we propose a bootstrapping approach that resamples residuals with replacement. While bootstrapping is not new to data processing in agronomic fields, we provide an example of how to conduct residual‐resampled bootstrapping with nonlinear regression to identify differences in response curves, optimum N rates, and maximum yields using the FertBoot package in R. Our example dataset provides clear evidence of the value of the bootstrapping approach, as it can aid in determining significant differences between even relatively small differences in optimum N rate. We encourage adoption of this approach as a way to accurately evaluate differences in optimum fertilizer levels between or among treatments to better inform future agronomic decision making.