bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das Treatment Exit Options for Uveitis (TOFU) Register: Einbindung von Patienten in die Evidenzgenerierung
Authors: Li Jeany Q. , Dell Jennifer , Höller Tobias , Fink David , Schmid Matthias , Heinz Carsten , Finger Robert P. 
Published: November 2021

ZusammenfassungUveitis ist eine seltenere entzündliche Augenerkrankung, die zu schwerer Sehbehinderung und Blindheit führen kann und besonders Menschen im berufstätigen Alter betrifft. Besonders schwere Verläufe, die meist einer immunmodulierenden Therapie (IMT) bedürfen, treten bei einer Uveitis auf, die die hinteren Teile des Auges oder das ganze Auge betreffen und nicht infektiöser Ursache sind. Für diese Formen der Erkrankung gibt es nur wenig gute Evidenz zum langfristigen Management der Erkrankung und insbesondere zur Beendigung oder Reduktion einer IMT. Das Treatment exit Options For non-infectious Uveitis (TOFU) Register der Sektion Uveitis der Deutschen Ophthalmologischen Gesellschaft (DOG) hat das Ziel, Krankheitsverläufe von Patienten mit nicht-infektiöser nicht-anteriorer Uveitis zu dokumentieren und Empfehlungen zur Beendigung einer IMT zu erarbeiten. Ein wesentlicher Aspekt des TOFU-Registers ist die aktive Einbeziehung von Patienten in die Erfassung Patienten-berichteter Endpunkte über ein Patientenmodul (Patient Reported Outcomes, PROs). Neben seh- und gesundheitsbezogener Lebensqualität werden auch Fragebögen zur Therapieadhärenz, Produktivität und Auswirkungen der Therapien eingesetzt. Die eingesetzten Fragebögen wurden in dieser Kombination in einer Pilotstudie mit Patienten getestet und es hat sich gezeigt, dass die wesentlichen Patienten-relevanten Aspekte der Erkrankung und deren Auswirkungen auf den Alltag erfasst werden. Das Patientenmodul, wie das Register selbst, nutzt zur Dokumentation die electronic data capture (EDC)-Software REDCap (Version 9, Vanderbilt University, USA). Durch die Einbindung von Patienten in sowohl die Konzeption des Registers als auch die fortlaufende Datensammlung wird sichergestellt, dass Patienten-relevante Evidenz für z. B. die Erstellung von Leitlinien und Behandlungsempfehlungen generiert wird.
Inanspruchnahme medizinischer Versorgung durch wohnungslose Menschen
– der Einfluss von zugangsförderlichen Faktoren, Schmerzen und
Gender untersucht anhand des Gelberg-Andersen-Modells
Authors: Brettel Paul , Beier Elena , Maun Andy , Jung Petra 
Published: November 2021

ZusammenfassungZiel der vorliegenden Arbeit war es, Einflussfaktoren auf die Inanspruchnahme
medizinischer Versorgungsangebote durch wohnungslose Menschen zu ermitteln. Im
Rahmen einer Feldstudie wurden 51 wohnungslose Männer und 47
wohnungslose Frauen in Baden-Württemberg mit einem für diese
Studie konzipierten Fragebogen in face-to-face-Interviews befragt. Anhand
multipler logistischer Regressionsmodelle in Anlehnung an das Gelberg-Andersen
Behavioral Model for Vulnerable Populations wurden Einflussfaktoren auf die
Inanspruchnahme medizinischer Versorgungsangebote ermittelt. Erfüllte
alltägliche Grundbedürfnisse (OR 1,33, 95%-KI
[1,03–1,72] bzgl. Wahrnehmung von Impfungen), eine feste
primärmedizinische Anlaufstelle (OR 12,2 [1,81–82] bzgl.
Wahrnehmung von Früherkennungsuntersuchungen; quasi-vollständige
Trennung bzgl. Inanspruchnahme hausärztlicher Versorgung), soziale
Unterstützungssysteme (OR 2,9 [1,13–7,5] bzgl. Wahrnehmung von
Früherkennungsuntersuchungen; OR 0,63 [0,41–0,98] bzgl.
Aufsuchen von Notaufnahmen) und technische Unterstützungssysteme (OR 2,2
[1,13–4,4] bzgl. Inanspruchnahme hausärztlicher Versorgung)
hatten einen günstigen Einfluss auf das Inanspruchnahmemuster. Schmerzen
führten zu einer häufigeren Inanspruchnahme von Notaufnahmen (OR
1,72 [1,22–2,4]) und stationärer Versorgung (OR 1,66
[1,19–2,3]). Es zeigten sich Unterschiede zwischen den
Geschlechtergruppen. Die genannten Einflussfaktoren sind in der Versorgung
wohnungsloser Menschen gezielt zu adressieren. Zur Früherkennung und
Bearbeitung komplexer sozialer und gesundheitlicher Problemlagen vulnerabler
Bevölkerungsgruppen ist eine Integration sozialer Versorgungsangebote in
die medizinische Regelversorgung notwendig. Dies erfordert interprofessionelle
Ansätze in der medizinischen Aus-und Weiterbildung, die die Lebenslagen
vulnerabler Bevölkerungsgruppen und soziale Determinanten von Gesundheit
in den Blick rücken.
Alkoholintoxikationen junger Menschen in Bayern während der Covid-19-Pandemie
Authors: Härtl Sabine , Koytek Annalena , Wolstein Jörg 
Published: November 2021

Zusammenfassung
Ziel Es sollen Erkenntnisse zum Alkoholkonsumverhalten junger Menschen in Bayern mit Alkoholintoxikation während der Covid-19-Pandemie gewonnen werden. Dabei soll auf die Anzahl der Klinikeinlieferungen aufgrund von Alkoholintoxikationen, Charakteristika der eingelieferten Jugendlichen im Vergleich von 2020 gegenüber den Vorjahren und auf die Entwicklung des Rauschtrinkens nach Einschätzung von Suchtpräventionsfachkräften eingegangen werden.
Methodik Die Fragestellung soll mithilfe von drei Datenquellen beantwortet werden: Befragung von Suchtpräventionsfachkräften im Jahr 2020 (n=41), Befragung von Jugendlichen, die aufgrund einer Alkoholintoxikation in eine Klinik eingeliefert wurden im Zeitraum von 2014 bis 2020 (n=5046) und Erhebung der Anzahl der vollstationär entlassenen Jugendlichen mit der Diagnose F10 oder T51 in einer Kooperationsklinik des HaLT-Projekts im Zeitraum von 2018 bis 2020 (n=371).
Ergebnisse Die Häufigkeit von Klinikeinlieferungen aufgrund einer Alkoholintoxikation ist bei jungen Menschen in Bayern im Jahr 2020 gegenüber den Vorjahren rückläufig. Zugleich zeigen sich Hinweise auf häufigeres riskantes Konsumverhalten bei den intoxikierten Jugendlichen im Jahr 2020 gegenüber den Vorjahren hinsichtlich der häufigeren Konsumursachen absichtliches Betrinken und Missbrauch nach DSM-IV, der gestiegenen durchschnittlichen Blutalkoholkonzentrationen männlicher Jugendlicher, des sinkenden Bewusstseins für die potentiell lebensbedrohlichen Risiken der Intoxikation und des gestiegenen Anteils wiederholt intoxikierter junger Menschen. Die Häufigkeit des Rauschtrinkens scheint nach erster Einschätzung im Jahr 2020 gegenüber den Vorjahren rückläufig zu sein.
Schlussfolgerung Potentielle Risikogruppen wie männliche Jugendliche und wiederholt intoxikierte junge Menschen sowie neue Konsumsettings sollten in den Fokus weiterer Forschung und der Suchtpräventionsarbeit unter Pandemiebedingungen genommen werden. Inwiefern diese neuen Konsummuster nach Überwindung der Pandemie fortbestehen, kann aktuell nicht beurteilt werden.
Möglichkeiten der Überbrückung des therapiefreien Intervalls bei Notfällen
Authors: Sefrin Peter , Schua Rainer 
Published: November 2021

ZusammenfassungBei Notfällen besteht bis zur professionellen Hilfe durch den Rettungsdienst ein therapiefreies Intervall, das durch verschiedene Organisationsformen überbrückt werden soll, um dem
Notfallpatienten eine adäquate Erste Hilfe zuteilwerden zu lassen. Die Hilfsfrist des Rettungsdienstes ist eine länderdifferente planerische Größe und bietet keine ausreichende Gewähr eines
frühzeitigen Erreichens des Patienten, sondern definiert vielmehr die Infrastruktur des Rettungsdienstes. Eine spontane Hilfeleistung durch Notfallzeugen ist trotz des Bemühens einer
bundesweiten Schulung der Bevölkerung in Erster Hilfe nicht durchgehend zu erwarten. Die Telefonreanimation durch die Leitstelle mit Anleitung des Anrufers zur Reanimation stellt eine
Möglichkeit zum frühzeitigen Beginn einer Wiederbelebung dar. Engagierte ausgebildete, zufällig erreichbare Ersthelfer können über verschiedene Kommunikationsmittel an den Notfallort
entsandt werden, um Erste Hilfe zu leisten. Eine organisierte Überbrückung des therapiefreien Intervalls stellen die verschiedenen First-Responder-Systeme dar. Eine Sonderform ist der dem
Rettungsdienst zugehörige Gemeindenotfallsanitäter. Die Vor- und Nachteile der einzelnen Organisationssysteme werden gegenübergestellt.
Ethics in canine reproduction – a survey among veterinarians who provide canine reproductive services
Authors: Arlt Sebastian P. , Øvregaard Helen 
Published: November 2021

AbstractObjective Several dog breeds suffer from health and welfare problems due to unfavorable anatomies and high prevalence of inherited diseases. Veterinarians should care for animal health and welfare but they may also be involved in breeding management including the use of reproductive techniques.Material and methods An online survey was conducted to find out how veterinarians who are involved in small animal reproduction regard ethical issues, which services they provide, how they discuss and handle ethical concerns and talk about them with breeders.Results In total, 83 participants mainly from Europe completed the online survey. Opinions on which interventions are ethical or not were heterogeneous. Most respondents (79.2 %) found it ethical to perform artificial insemination (AI) in dogs which did not reproduce naturally before. However, 62.7 % of participants stated that surgical insemination is not ethical. Elective cesarean sections are considered not ethical by approximately half of the participants. A closer look at responses to the questions of whether AI is ethical under specific conse quences suggests that most veterinarians are making ethical and value judgments in terms of what is justifiable or not. However, more than 80 % feel at least sometimes compromised by ethical conflicts.Clinical relevance This research intended to foster discussion of this topic. International strategies should be developed to support solving conflicts and dilemmas related to ethical issues in dog breeding and assisted reproduction, as well as diminishing physical disabilities and heritable diseases.
Moderate Intensity Cycling Combined with Cognitive Dual-task Improves
Selective Attention
Authors: Kunzler Marcos Roberto , Carpes Felipe P. 
Published: November 2021

AbstractPhysical and cognitive exercises have positive long-term effects on cognitive
capacities. However, acute effects still are controversial. Here we determine
the acute effects of physical exercise combined with concurrent cognitive
exercise on cognitive performance in young adults. Simple reaction time,
selective attention, and memory were evaluated in 23 young men before and after
30 min of stationary cycling exercise, 30 min of stationary
cycling exercise combined with cognitive exercise, and 30 min of rest.
Exercise intensity was continuously controlled to ensure exercise at moderate
intensity. We found that physical exercise combined with cognitive dual-task
improves selective attention. Both exercise conditions showed similar effects on
simple reaction time, and memory was not affected by the different exercise
conditions. We conclude that the combination of cycling exercise at moderate
intensity with a cognitive exercise acutely improves selective attention in
young adults. These results can be of particular interest for interventions
aiming at improving selective attention in sports and for older adults and
individuals with difficulty to suppress and filter out task-irrelevant
information, like when receiving instruction or learning a new task or
concept.
Mass-Like Extreme Wall Thickening of the Entire Common Bile Duct in a Case of Portal Cavernoma Cholangiopathy
Authors: Gunasekaran Veeraraghavan , Mohan Supraja Laguduva , Chakkalakkoombil Sunitha Vellathussery , Senthamizhselvan Kuppusamy 
Published: November 2021

AbstractPortal cavernoma cholangiopathy (PCC) refers to the cholangiographic abnormalities that occur in patients with portal cavernoma. These abnormalities may be either due to chronic portal vein thrombosis or extrahepatic portal vein occlusion. These abnormalities occur due to enlargement of the bridging tortuous paracholedochal, epicholedochal, and cholecystic veins exerting pressure on the bile ducts. Ischemic changes can also occur in the bile duct due to portal vein thrombosis, which affects the microvascular circulation or associated hepatic artery thrombosis. These may be either reversible with shunt procedures such as transjugular intrahepatic portosystemic shunt (TIPS) or irreversible in the advanced stage, leading to recurrent episodes of biliary pain, cholangitis, and cholestasis. Occasionally it may present as mass-like diffuse common bile duct (CBD) wall thickening, which may be confused with mimickers like primary CBD lymphoma, immunoglobulin G4-related sclerosing cholangitis, and even cholangiocarcinoma on imaging. Thus, we need to be aware of the mass-forming PCC imaging findings to avoid unnecessary invasive procedures like biopsy or surgical intervention. Here, we present a case of PCC, which presented as mass-like diffuse CBD wall thickening with patent lumen on ultrasound that led to further workup with contrast-enhanced computed tomography and magnetic resonance imaging. The wall thickening showed persistent delayed enhancement, no significant diffusion restriction, and there was also associated superior mesenteric vein thrombosis with multiple mesenteric collaterals. A positron emission tomography-CT scan also ruled out malignant disease as there was no uptake. Finally, a diagnosis of mass-forming PCC was made by combining imaging features and excluding other causes.
Osteogenesis Imperfecta and Split Foot Malformation due to 7q21.2q21.3 Deletion Including COL1A2, DLX5/6 Genes: Review of the Literature
Authors: Öztürk Özden , Bagis Haydar , Bolu Semih 
Published: November 2021

AbstractCopy number variation in loss of 7q21 is a genetic disorder characterized by split hand/foot malformation, hearing loss, developmental delay, myoclonus, dystonia, joint laxity, and psychiatric disorders. Osteogenesis imperfecta caused by whole gene deletions of COL1A2 is a very rare condition. We report a Turkish girl with ectrodactyly, joint laxity, multiple bone fractures, blue sclera, early teeth decay, mild learning disability, and depression. A copy number variant in loss of 4.8 Mb at chromosome 7 (q21.2q21.3) included the 58 genes including DLX5, DLX6, DYNC1I1, SLC25A13, SGCE, and COL1A2. They were identified by chromosomal microarray analysis. We compared the findings in our patients with those previously reported. This case report highlights the importance of using microarray to identify the genetic etiology in patients with ectrodactyly and osteogenesis imperfecta.
Classical electronic and molecular dynamics simulation for optical response of metal system
Authors: Yamada Atsushi 
Published: November 2021

An extended molecular dynamics simulation that incorporates classical free electron dynamics in the framework of the force-field model has been developed to enable us to describe the optical response of metal materials under the visible light electric field. In the simulation, dynamical atomic point charges follow equations of motion of classical free electrons that include Coulomb interactions with the oscillating field and surrounding atomic sites and collision effects from nearby electrons and ions. This scheme allows us to simulate an interacting system of metals with molecules using an ordinary polarizable force-field and preserves energy conservation in the case without applying an external electric field. As the first applications, we show that the presented simulation accurately reproduces (i) the classical image potential in a metal–charge interaction system and (ii) the dielectric function of bulk metal. We also demonstrate (iii) calculations of absorption spectra of metal nano-particles with and without a water solvent at room temperature, showing reasonable red-shift by the solvent effect, and (iv) plasmon resonant excitation of the metal nano-particle in solution under the visible light pulse and succeeding energy relaxation of the absorbed light energy from electrons to atoms on the metal and to the water solvent. Our attempt thus opens the possibility to expand the force-field based molecular dynamics simulation to an alternative tool for optical-related fields.
Investigation of performance properties of plastic optical fibres used in a traffic light system
Authors: Savović S. , Djordjevich A. , Min R. , Savović I. 
Published: November 2021

Abstract
We investigate the performance properties of a multimode plastic optical fibre (POF) used in a traffic light system. An analytical function is proposed for predicting the angular power distribution at the output end of a multimode optical fibre when the beam at the input end of the fibre is centrally launched along the fibre axis. We demonstrate how mode coupling affects the output angular power distribution along the fibre and, therefore, the performance of optical fibre used as part of a traffic light system. It is found that as the length of the POF increases, the angular power distribution broadens until it reaches a length at which a steady-state distribution (SSD) is achieved. This broadening is insignificant at short POF lengths of up to 10 m. As a result, the effective radiation area at the output end of any long POF as part of different light systems, such as traffic, building, and bridge light systems, can be determined.
Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection
Authors: Bomidi Carolyn , Robertson Matthew , Coarfa Cristian , Estes Mary K. , Blutt Sarah E. 
Published: November 2021

Significance
Rotavirus infects enterocytes at the tips of intestinal villi, leading to damage. Single-cell RNA sequencing of the infected murine intestinal epithelium reveals broad responses, including expansion of the stem cell and immature enterocyte populations. Subsets of stem cells enter the cell cycle more frequently, resulting in production of more enterocytes to compensate for damaged enterocytes at the villus tip. The presence of viral transcripts in tuft cells and evidence of tuft cell transcriptional activation suggests that tuft cells contribute important signals to the epithelial response following damage. Until now the mechanism of repair following viral damage in the intestinal epithelium has remained uncharacterized. We find that intestinal regeneration and repair require cooperation of several specialized epithelial cells.
Molecular dynamics investigation on tilt grain boundary energies of beta-titanium and tungsten at high temperature
Authors: He Hong , Ma Shangyi , Wang Shaoqing 
Published: November 2021

Abstract
The grain boundary energies (GBEs) of symmetric tilt grain boundaries (STGBs) and asymmetric tilt grain boundaries (ATGBs) for W at 0 and 2400 K and β-Ti at 1300 K were calculated by means of molecular statics and dynamics simulations to investigate the effects of temperature on GBE and the relationships between GBEs and grain boundary (GB) planes. Generally, the variation trends of GBE with the tilt angle are similar for the three cases, when the tilt axis is specified. It is of course that these similarities result from their similar GB microstructures in most cases. However, the variation trends of GBE with tilt angle are somewhat different between β-Ti at 1300 K and W at 2400 K for STGBs with <100> and <110> tilt axes. This difference mainly stems from the following two reasons: firstly, the GB microstructures of W at 2400 K and β-Ti at 1300 K are different for some STGBs; secondly, the atoms at the STGB of β-Ti at 1300 K tend to evolve into the local ω- or α-like structures distributed at the STGB for some STGBs with <110> tilt axis, which makes the corresponding STGBs more stable, thereby decreasing the GBEs. Furthermore, a geometric parameter θ, the angle between the misorientation axis and the GB plane, was defined to explore the relationships between GBEs and GB planes. It was found that the relationships between GBEs and GB planes can be described by some simple functions of sin(θ) for the GBs with definite lattice misorientation, which can well explain and predict the preferred GB planes for the GBs having the same lattice misorientation. Our calculations not only extend the investigation of GBs to higher temperature, but also deepen the understanding on the temperature contributions to the microstructure evolution at GBs and on the relationships between GBEs and possible geometric parameters.
Design and development of electrochemical potentiostat circuit for the sensing of toxic cadmium and lead ions in soil
Authors: Katiyar Rajani , Usha Rani K R , Sindhu TS , Sneha Jain HD , Vidhyashree  , Ashoka S , Channegowda Manjunatha 
Published: November 2021

Abstract
Contamination of heavy metal ions in soils has proved to be a significant concern and it poses many health risks. Conventional methods used for the identification and detection of heavy metals were non portable and not suitable for onsite applications. The proposed work is to design a low cost electronic circuit for the detection of cadmium and lead ions in soil sample. A screen printed electrode and a Glassy Carbon electrode are interfaced with a designed circuit for electrochemical analysis. Anodic stripping voltammetry is the theory behind the metal ion detection process. Based on the current peaks observed in the voltammetry process, the presence of lead and cadmium in a given sample can be determined. A voltage controlled circuit is designed to perform the functions of Ec-Lab which makes this system portable. The results are compared with that of the potentiostat device to evaluate the accuracy of the designed circuit.
Feasibility of computerized clinical decision support for pediatric to adult care transitions for patients with special healthcare needs
Authors: Koscielniak Nikolas J , Dharod Ajay , Moses Adam , Bundy Richa , Feiereisel Kirsten B , Albertini Laurie W , Palakshappa Deepak 
Published: November 2021

Abstract
The objective of this study was to determine the feasibility of a computerized clinical decision support (cCDS) tool to facilitate referral to adult healthcare services for children with special healthcare needs. A transition-specific cCDS was implemented as part of standard care in a general pediatrics clinic at a tertiary care academic medical center. The cCDS alerts providers to patients 17–26 years old with 1 or more of 15 diagnoses that may be candidates for referral to an internal medicine adult transition clinic (ATC). Provider responses to the cCDS and referral outcomes (e.g. scheduled and completed visits) were retrospectively analyzed using descriptive statistics. One hundred and fifty-two patients were seen during the 20-month observation period. Providers referred 87 patients to the ATC using cCDS and 77% of patients ≥18 years old scheduled a visit in the ATC. Transition-specific cCDS tools are feasible options to facilitate adult care transitions for children with special healthcare needs.
A heterogeneous lattice structure modeling technique supported by multiquadric radial basis function networks
Authors: Liu Yuan , Yang Huiyuan , Zhao Yaoyao Fiona , Zheng Guolei 
Published: November 2021

ABSTRACTWith the rapid advancement of the multimaterial additive manufacturing (AM) technology, the heterogeneous lattice structures (HLSs) comprising the multiphase materials with gradual variations have become feasible and accessible to the industry. However, the multimaterial AM capabilities have far outpaced the modeling capability of design systems to model and thus design novel HLSs. To further expand the design space for the utilization of AM technology, this paper proposes a method for modeling HLS with complex geometries and smooth material transitions. The geometric modeling and material modeling problems are formulated in a rigorous and computationally effective manner. The geometric complexity of HLS is significantly reduced by a semi-analytical unit cell decomposition strategy that is applied to split HLS into material units: struts and connectors. The smooth material transitions of the connector associated with multimaterial struts are realized by interpolating the discrete material property values defined at control points using a multiquadric radial basis function network.