bluuebunny/crossref_metadata_2025_split huggingface dataset:
Механізм управління розвитком сучасних підприємств як адаптаційна перевага їх стратегічного функціонування
Authors: Прохорова Вікторія , Залуцька Христина , Маслак Тетяна 
Published: December 2021

Анотація. Результативність прийнятих рішень щодо розвитку підприємства в стратегічному періоді залежить від ефективного механізму управління обраним напрямком розвитку, сформованим адекватно умовам функціонування сучасних підприємств. Відповідно, метою статті є формування і обґрунтування структури механізму управління розвитком підприємств з позиції основної її адаптаційної переваги для ефективної стратегічної діяльності підприємств в сучасних умовах функціонування.
Для досягнення поставленої мети та вирішення основних дослідницьких завдань використано такі основні методи: теоретичного узагальнення; аналізу й синтезу; декомпозиції та структурно-логічного аналізу; порівняльного аналізу, індукції та дедукції; систематизації та узагальнення; структурно-логічний.
Обґрунтовано необхідність формування інтегрованого механізму управління розвитком підприємств як основну їх адаптаційну можливість до сучасних умов функціонування за рахунок забезпечення довгострокової конкурентоспроможної діяльності. Описано структуру інтегрованого механізму управління розвитком сучасних підприємств. Доведено доцільність виділення у його складі окремих локальних механізмів відповідної спеціалізації (механізм перманентної діагностики параметрів розвитку; механізм забезпечення бізнес-активності; адаптаційно-комунікаційний механізм; механізм досягнення стратегічних цілей; мотиваційний механізм; механізм інтелектуалізації управлінського процесу; механізм ефективного розподілу ресурсів; механізм забезпечення інституціональної архітектоніки; механізм управління дисбалансами розвитку), які забезпечать оперативно-адекватне реагування на багатоаспектні зміни умов функціонування підприємства, а їх взаємодія сприятиме збалансованому нарощенню підприємством конкурентних переваг для ефективного функціонування в стратегічному періоді. Охарактеризовано кожен із виділених локальних механізмів та описано особливості взаємно обумовлюючого їх впливу між собою.
Ключові слова: механізм управління розвитком; стратегічний період; локальні механізми; конкурентні переваги; адаптаційна перевага.
The Strengthening of Religious Tolerance through Islamic Education Learning Based on Nonviolence Culture in Public University
Authors: Siti Mutholingah  
Published: December 2021

The public university is an educational institution with heterogeneous and multicultural socio-religious and cultural background conditions for students, including the State University of Malang (UM). The problem that multicultural and multireligious campuses often face is intolerant behavior that allows acts of violence to occur. Nevertheless, interestingly, this does not happen at UM. That is because UM seeks to develop a tolerant attitude of students through Islamic religious education with a culture of non-violence. The aims of this study are: (1) to find out what nonviolence cultural values ​​exist in UM, and (2) what efforts are made by UM to strengthen religious tolerance through Islamic religious education with a culture of nonviolence. This qualitative research applies a case study with data collection techniques through interviews, observation, and documentation. Data analysis includes data collection, condensation, data display, and concluding. The results of this study, namely: (1) The values of the non-violent culture that is being developed by the State University of Malang (UM) are: (a) Rahmatan Lil'alamin values, (b) Peacebuilding values, and (c) Tolerance-values. (2) The strengthening of religious tolerance through non-violent culture through PAI learning at UM includes: (a) The PAI learning process is carried out in the classroom learning directly (2 credits) and in the form of Tafaqquhfiidiinil Islam (TDI) activities which are including public lectures PAI learning and intensive guidance on reading the Qur'an (1 credit) for a total of credit is 3. (b) Through Qur'an Study Club, and (c) Seminar activities on multiculturalism, tolerance, and religious harmony.
Qualidade de vida e estado nutricional de idosos institucionalizados e não institucionalizados
Authors: Facchini Tainá , Adami Fernanda Scherer , Trindade Nathascha dos Santos , Führ Jéssica Carina , Lavall Janine Maria , Delazzeri Fabiani Cristina Lassen , Conde Simara Rufatto , Bertani Juliana Paula Bruch , Fassina Patricia 
Published: December 2021

Objetivo: Associar os domínios de qualidade de vida com o estado nutricional e idade de idosos não institucionalizados e residentes em Instituições de Longa Permanência para Idosos (ILPIs). Metodologia: Trata-se de um estudo retrospectivo, transversal, de natureza quantitativa, com 105 idosos não institucionalizados atendidos em uma Estratégia de Saúde da Família (ESF), município de Lajeado-RS, e 245 idosos institucionalizados residentes em ILPIs públicas e privadas, no Rio Grande do Sul. Utilizou-se o Questionário de Avaliação de Qualidade de Vida The World Health Organization Quality of Life – WHOQOL-bref composto de 26 questões, de escala hedônica de 1 a 5. Realizou-se aferição do peso e estatura, para determinar o índice de massa corporal (IMC) e classificar o estado nutricional conforme Organização Pan-Americana da Saúde (2002). Consideraram-se significativos os resultados a um nível de significância máxima de 5%. Resultados: O maior escore de qualidade de vida dos idosos observou-se no domínio psíquico 45±27,53, seguido do ambiental 41,46±18,23, social 40,82±30,68 e físico 39,28±20,10, sendo que os domínios de qualidade de vida foram significativamente superiores entre os idosos com 60 a 69 anos (p≤0,01), com estado nutricional classificados como obesidade (p≤0,01) e os não institucionalizados quando comparados com os institucionalizados. Conclusão: A percepção dos domínios de qualidade de vida dos idosos estudados foi maior no domínio psíquico e menor no físico. Os idosos mais jovens, com obesidade e não institucionalizados demonstraram uma melhor percepção da qualidade de vida em todos os domínios.
Perfil de sensibilidade bacteriana em um hospital público de Teresina
Authors: Andrade Tarcila Ibiapina , Lemos Yuthanna Figueiredo Martins , Silva Williams Cardec da 
Published: December 2021

Objetivou-se com esse estudo, analisar o perfil de sensibilidade bacteriana por meio de laudos de culturas coletadas em pacientes de Unidade de Terapia Intensiva (UTI), evidenciando o direcionamento para conduta terapêutica. Trata-se de um estudo descritivo, retrospectivo, com abordagem quantitativa das culturas de urina, sangue e secreção traqueal. A amostra foi constituída por 330 laudos de culturas positivas de pacientes internados no período de 01 de fevereiro de 2019 a 01 de fevereiro de 2020 na UTI do Hospital de Urgência de Teresina Dr. Zenon Rocha. Do total de laudos analisados, 227 (68,50%) foram positivos em secreção traqueal, 71 (21,50%) em hemocultura e 32 (9,70%) em urocultura. Sendo a Pseudomonas aeruginosa a mais prevalente na secreção traqueal, a Acinetobacter coagulase negativa na hemocultura e Klebsiella pneumoniae na urocultura. Diante disso, é possível afirmar que os resultados obtidos seguiram o padrão de estudos semelhantes realizados em outros locais, com particularidades decorrentes da epidemiologia da região estudada.
Assessment of the quality of life of patients with total jaw defects
Authors: Sletov A. A. , Mikhalchenko D. V. , Zhidovinov A. V. , Serbin A. S. , Aleshanov K. A. , Bobrov D. S. , Tkacheva S. A. 
Published: December 2021

Cancer of the lower jaw is one of the most common causes of the development of total defects. There are many indices and indicators to assess the quality of life of patients with this pathology, but they do not fully describe the features of their postoperative rehabilitation. The question of developing an evaluation criterion for the introduction of a special device in patients with subtotal defects of the lower jaw remains open.Material and methods. In the period from 2010 to 2021, 100 patients with subtotal defects of the lower jaw, aged 30 to 65 years old, who are being treated in the Department of Maxillofacial Surgery at the Department of Maxillofacial Surgery of the GBUZ SKKKB, were interviewed. All patients were divided into 2 groups of 50 people each. In the main rehabilitation was carried out using a special device to optimize the biomechanics of the lower jaw, in the control group, rehabilitation was carried out without one. The article presents the results of assessing the quality of life, which were carried out using a special questionnaire.Conclusions. This questionnaire makes it possible to assess the standard of living of patients using a special device at the stages of rehabilitation.
Preeclamptic Women Have Disrupted Placental microRNA Expression at the Time of Preeclampsia Diagnosis: Meta-Analysis
Authors: Cirkovic Andja , Stanisavljevic Dejana , Milin-Lazovic Jelena , Rajovic Nina , Pavlovic Vedrana , Milicevic Ognjen , Savic Marko , Kostic Peric Jelena , Aleksic Natasa , Milic Nikola , Stanisavljevic Tamara , Mikovic Zeljko , Garovic Vesna , Milic Natasa 
Published: December 2021

Introduction: Preeclampsia (PE) is a pregnancy-associated, multi-organ, life-threatening disease that appears after the 20th week of gestation. The aim of this study was to perform a systematic review and meta-analysis to determine whether women with PE have disrupted miRNA expression compared to women who do not have PE.Methods: We conducted a systematic review and meta-analysis of studies that reported miRNAs expression levels in placenta or peripheral blood of pregnant women with vs. without PE. Studies published before October 29, 2021 were identified through PubMed, EMBASE and Web of Science. Two reviewers used predefined forms and protocols to evaluate independently the eligibility of studies based on titles and abstracts and to perform full-text screening, data abstraction and quality assessment. Standardized mean difference (SMD) was used as a measure of effect size.Results: 229 publications were included in the systematic review and 53 in the meta-analysis. The expression levels in placenta were significantly higher in women with PE compared to women without PE for miRNA-16 (SMD = 1.51,95%CI = 0.55–2.46), miRNA-20b (SMD = 0.89, 95%CI = 0.33–1.45), miRNA-23a (SMD = 2.02, 95%CI = 1.25–2.78), miRNA-29b (SMD = 1.37, 95%CI = 0.36–2.37), miRNA-155 (SMD = 2.99, 95%CI = 0.83–5.14) and miRNA-210 (SMD = 1.63, 95%CI = 0.69–2.58), and significantly lower for miRNA-376c (SMD = –4.86, 95%CI = –9.51 to –0.20). An increased level of miRNK-155 expression was found in peripheral blood of women with PE (SMD = 2.06, 95%CI = 0.35–3.76), while the expression level of miRNA-16 was significantly lower in peripheral blood of PE women (SMD = –0.47, 95%CI = –0.91 to –0.03). The functional roles of the presented miRNAs include control of trophoblast proliferation, migration, invasion, apoptosis, differentiation, cellular metabolism and angiogenesis.Conclusion: miRNAs play an important role in the pathophysiology of PE. The identification of differentially expressed miRNAs in maternal blood creates an opportunity to define an easily accessible biomarker of PE.
DNA Methylation Data-Based Classification and Identification of Prognostic Signature of Children With Wilms Tumor
Authors: Tang Fucai , Lu Zeguang , Lei Hanqi , Lai Yongchang , Lu Zechao , Li Zhibiao , Tang Zhicheng , Zhang Jiahao , He Zhaohui 
Published: December 2021

Background: As an epigenetic alteration, DNA methylation plays an important role in early Wilms tumorigenesis and is possibly used as marker to improve the diagnosis and classification of tumor heterogeneity.Methods: Methylation data, RNA-sequencing (RNA-seq) data, and corresponding clinical information were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. The prognostic values of DNA methylation subtypes in Wilms tumor were identified.Results: Four prognostic subtypes of Wilms tumor patients were identified by consensus cluster analysis performed on 312 independent prognostic CpG sites. Cluster one showed the best prognosis, whereas Cluster two represented the worst prognosis. Unique CpG sites identified in Cluster one that were not identified in other subtypes were assessed to construct a prognostic signature. The prognostic methylation risk score was closely related to prognosis, and the area under the curve (AUC) was 0.802. Furthermore, the risk score based on prognostic signature was identified as an independent prognostic factor for Wilms tumor in univariate and multivariate Cox regression analyses. Finally, the abundance of B cell infiltration was higher in the low-risk group than in the high-risk group, based on the methylation data.Conclusion: Collectively, we divided Wilms tumor cases into four prognostic subtypes, which could efficiently identify high-risk Wilms tumor patients. Prognostic methylation risk scores that were significantly associated with the adverse clinical outcomes were established, and this prognostic signature was able to predict the prognosis of Wilms tumor in children, which may be useful in guiding clinicians in therapeutic decision-making. Further independent studies are needed to validate and advance this hypothesis.
Transcriptomic and Metabolomic Profiling in Helicobacter pylori–Induced Gastric Cancer Identified Prognosis- and Immunotherapy-Relevant Gene Signatures
Authors: Liu Duanrui , Zhu Jingyu , Ma Xiaoli , Zhang Lulu , Wu Yufei , Zhu Wenshuai , Xing Yuanxin , Jia Yanfei , Wang Yunshan 
Published: December 2021

Background: Chronic Helicobacter pylori (HP) infection is considered the major cause of non-cardia gastric cancer (GC). However, how HP infection influences the metabolism and further regulates the progression of GC remains unknown.Methods: We comprehensively evaluated the metabolic pattern of HP-positive (HP+) GC samples using transcriptomic data and correlated these patterns with tumor microenvironment (TME)–infiltrating characteristics. The metabolic score was constructed to quantify metabolic patterns of individual tumors using principal component analysis (PCA) algorithms. The expression alterations of key metabolism-related genes (MRGs) and downstream metabolites were validated by PCR and untargeted metabolomics analysis.Results: Two distinct metabolic patterns and differential metabolic scores were identified in HP+ GC, which had various biological pathways in common and were associated with clinical outcomes. TME-infiltrating profiles under both patterns were highly consistent with the immunophenotype. Furthermore, the analysis indicated that a low metabolic score was correlated with an increased EMT subtype, immunosuppression status, and worse survival. Importantly, we identified that the expression of five MRGs, GSS, GMPPA, OGDH, SGPP2, and PIK3CA, was remarkably correlated with HP infection, patient survival, and therapy response. Furthermore, the carbohydrate metabolism and citric acid may be downstream regulators of the function of metabolic genes in HP-induced GC.Conclusion: Our findings suggest that there is cross talk between metabolism and immune promotion during HP infection. MRG-specific transcriptional alterations may serve as predictive biomarkers of survival outcomes and potential targets for treatment of patients with HP-induced GC.
Metal-Free Pyrene-Based Conjugated Microporous Polymer Catalyst Bearing N- and S-Sites for Photoelectrochemical Oxygen Evolution Reaction
Authors: Das Sabuj Kanti , Shyamal Sanjib , Das Manisha , Mondal Saptarsi , Chowdhury Avik , Chakraborty Debabrata , Dey Ramendra Sundar , Bhaumik Asim 
Published: December 2021

The development of an efficient, sustainable, and inexpensive metal-free catalyst for oxygen evolution reaction (OER) via photoelectrochemical water splitting is very demanding for energy conversion processes such as green fuel generators, fuel cells, and metal-air batteries. Herein, we have developed a metal-free pyrene-based nitrogen and sulfur containing conjugated microporous polymer having a high Brunauer-Emmett-Teller surface area (761 m2 g−1) and a low bandgap of 2.09 eV for oxygen evolution reaction (OER) in alkaline solution. The π-conjugated as-synthesized porous organic material (PBTDZ) has been characterized by Fourier transform infrared spectroscopy (FT-IR), solid-state 13C (cross-polarization magic angle spinning-nuclear magnetic resonance) CP-MAS NMR, N2 adsorption/desorption analysis, field-emission scanning electron microscope (FESEM), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA) experiments. The material acts as an efficient catalyst for photoelectrochemical OER with a current density of 80 mA/cm2 at 0.8 V vs. Ag/AgCl and delivered 104 µmol of oxygen in a 2 h run. The presence of low bandgap energy, π-conjugated conducting polymeric skeleton bearing donor heteroatoms (N and S), and higher specific surface area associated with inherent microporosity are responsible for this admirable photoelectrocatalytic activity of PBTDZ catalyst.
Comparison of Resting Full-Cycle Ratio and Fractional Flow Reserve in a German Real-World Cohort
Authors: Wienemann Hendrik , Meyer Annika , Mauri Victor , Baar Till , Adam Matti , Baldus Stephan , Halbach Marcel 
Published: December 2021

Objective: The aim of this study was to evaluate non-hyperemic resting pressure ratios (NHPRs), especially the novel “resting full-cycle ratio” (RFR; lowest pressure distal to the stenosis/aortic pressure during the entire cardiac cycle), compared to the gold standard fractional flow reserve (FFR) in a “real-world” setting.Methods: The study included patients undergoing coronary pressure wire studies at one German University Hospital. No patients were excluded based on any baseline or procedural characteristics, except for insufficient quality of traces. The diagnostic performance of four NHPRs vs. FFR ≤ 0.80 was tested. Morphological characteristics of stenoses were analyzed by quantitative coronary angiography.Results: 617 patients with 712 coronary lesions were included. RFR showed a significant correlation with FFR (r = 0.766, p &lt; 0.01). Diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of RFR were 78% (95% confidence interval = 75; 81), 72% (65; 78), 81% (77; 84), 63% (57; 69), and 86% (83; 89). Relevant predictors for discordance of RFR ≤ 0.89/FFR &gt; 0.8 were LAD lesions, peripheral artery disease, age, female sex and non-focal stenoses. Predictors for discordance of RFR &gt; 0.89/FFR ≤ 0.8 included non-LCX lesions, percent diameter stenosis and previous percutaneous coronary intervention in the target vessel. RFR and all other NHPRs were highly correlated with each other.Conclusion: All NHPRs have a similar correlation with the gold standard FFR and may facilitate the acceptance and implementation of physiological assessments of lesion severity. However, we found ~20% discordant results between NHPRs and FFR in our “all-comers” German cohort.
Monitoring of Sierra Nevada Caves Reveals the Potential for Stalagmites to Archive Seasonal Variability
Authors: Wortham Barbara E. , Montañez Isabel P. , Bowman Kimberly , Kuta Daphne , Contreras Nora Soto , Brummage Eleana , Pang Allison , Tinsley John , Roemer-Baer Greg 
Published: December 2021

In the southwestern United States, California (CA) is one of the most climatically sensitive regions given its low (≤250 mm/year) seasonal precipitation and its inherently variable hydroclimate, subject to large magnitude modulation. To reconstruct past climate change in CA, cave calcite deposits (stalagmites) have been utilized as an archive for environmentally sensitive proxies, such as stable isotope compositions (δ18O, δ13C) and trace element concentrations (e.g., Mg, Ba, Sr). Monitoring the cave and associated surface environments, the chemical evolution of cave drip-water, the calcite precipitated from the drip-water, and the response of these systems to seasonal variability in precipitation and temperature is imperative for interpreting stalagmite proxies. Here we present monitored drip-water and physical parameters at Lilburn Cave, Sequoia Kings Canyon National Park (Southern Sierra Nevada), CA, and measured trace element concentrations (Mg, Sr, Ba, Cu, Fe, Mn) and stable isotopic compositions (δ18O, δ2H) of drip-water and for calcite (δ18O) precipitated on glass substrates over a two-year period (November 2018 to February 2021) to better understand how chemical variability at this site is influenced by local and regional precipitation and temperature variability. Despite large variability in surface temperatures and precipitation amount and source region (North Pacific vs. subtropical Pacific), Lilburn Cave exhibits a constant cave environment year-round. At two of the three sites within the cave, drip-water δ18O and δ2H are influenced seasonally by evaporative enrichment. At a third collection site in the cave, the drip-water δ18O responds solely to precipitation δ18O variability. The Mg/Ca, Ba/Ca, and Sr/Ca ratios are seasonally responsive to prior calcite precipitation at all sites but minimally to water-rock interaction. Lastly, we examine the potential of trace metals (e.g., Mn2+ and Cu2+as a geochemical proxy of recharge and find that variability in their concentrations has high potential to denote the onset of the rainy season in the study region. The drip-water composition is recorded in the calcite, demonstrating that stalagmites from Lilburn Cave, and potentially more regionally, could record seasonal variability in weather even during periods of substantially reduced rainfall.
Automatic Detection of Slow Slip Events Using the PICCA: Application to Chilean GNSS Data
Authors: Donoso F. , Moreno M. , Ortega-Culaciati F. , Bedford J. R. , Benavente R. 
Published: December 2021

The detection of transient events related to slow earthquakes in GNSS positional time series is key to understanding seismogenic processes in subduction zones. Here, we present a novel Principal and Independent Components Correlation Analysis (PICCA) method that allows for the temporal and spatial detection of transient signals. The PICCA is based on an optimal combination of the principal (PCA) and independent component analysis (ICA) of positional time series of a GNSS network. We assume that the transient signal is mostly contained in one of the principal or independent components. To detect the transient, we applied a method where correlations between sliding windows of each PCA/ICA component and each time series are calculated, obtaining the stations affected by the slow slip event and the onset time from the resulting correlation peaks. We first tested and calibrated the method using synthetic signals from slow earthquakes of different magnitudes and durations and modelled their effect in the network of GNSS stations in Chile. Then, we analyzed three transient events related to slow earthquakes recorded in Chile, in the areas of Iquique, Copiapó, and Valparaíso. For synthetic data, a 150 days event was detected using the PCA-based method, while a 3 days event was detected using the ICA-based method. For the real data, a long-term transient was detected by PCA, while a 16 days transient was detected by ICA. It is concluded that simultaneous use of both signal separation methods (PICCA) is more effective when searching for transient events. The PCA method is more useful for long-term events, while the ICA method is better suited to recognize events of short duration. PICCA is a promising tool to detect transients of different characteristics in GNSS time series, which will be used in a next stage to generate a catalog of SSEs in Chile.