bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statewide vaping product excise tax policy and use of electronic nicotine delivery systems among US young adults, 2014–2019
Authors: Han Dae-Hee , Seo Dong-Chul , Lin Hsien-Chang 
Published: July 2021

ObjectivesAn increasing number of US states have required a tax on electronic nicotine delivery systems (ENDS) in the past few years. This study evaluated the effect of statewide vaping product excise tax policy on ENDS use among young adults.MethodsWe used the two recent waves (2014–2019) of the Tobacco Use Supplement to the Current Population Survey. A total of 17 896 US young adults were analysed. Difference-in-differences approach along with weighted multilevel logistic regressions was used to evaluate the association of vaping product excise tax policy adoption with current ENDS use, accounting for the clustering of respondents within the same states.ResultsThere was an increase in current ENDS use prevalence from 2014–2015 (3.4%) to 2018–2019 (5.4%). Respondents living in states with vaping product excise tax policy showed significantly lower increase in ENDS use prevalence during the study period (interaction between within-state changes and between-state differences: adjusted OR (AOR)=0.57, 95% CI=0.35 to 0.91), controlling for other state-level policies and sociodemographic characteristics. Additional stratified analysis with state-fixed effects by vaping product excise tax policy implementation status showed consistent findings.ConclusionsOur findings suggest that adopting a vaping product excise tax policy may help reduce ENDS use and suppress the increase of ENDS use prevalence among young adults. Considering that there are still a number of US states that have not implemented vaping product excise tax policy, wider adoption of such policy across the nation would likely help mitigate ENDS use prevalence.
Existence of the Dharwar–Bastar–Singhbhum (DHABASI) megacraton since 3.35 Ga: constraints from the Precambrian large igneous province record
Authors: Srivastava Rajesh K. , Ernst Richard E. , Söderlund Ulf , Samal Amiya K. , Pandey Om Prakash , Gautam Gulab C. 
Published: July 2021

Abstract

We propose a Precambrian megacraton (consisting of two or more ancient cratons), DHABASI in the Indian Shield, which includes the Dharwar, Bastar and Singhbhum cratons. This interpretation is mainly based on seven large igneous provinces (LIPs) that are identified in these three cratons over the age range of
c.
3.35–1.77 Ga, a period of at least 1.6 Ga. The absence of any subsequent break-up of DHABASI since 1.77 Ga suggests that this megacraton has existed for the past 3.35 Ga. In addition to their use in recognizing this megacraton, these LIP events may also provide likely targets for Cu–Ni–Cr–Co–platinum group element deposits. We suggest that the megacraton DHABASI was an integral part of supercontinents/supercratons through Earth's history, and that it should be utilized as a distinct building block for palaeocontinental reconstructions rather than using the individual Dharwar, Bastar and Singhbhum cratons.
Comparing Age at Cancer Diagnosis between Hispanics and Non-Hispanic Whites in the United States
Authors: Parada Humberto , Vu Andrew H. , Pinheiro Paulo S. , Thompson Caroline A. 
Published: July 2021

Abstract

Background:
Population age structure may confound the comparison of age at cancer diagnosis across racial/ethnic groups. We compared age at cancer diagnosis for U.S. Hispanics, a population that is younger on average, and non-Hispanic whites (NHW), before and after adjustment for the age structure of the source population.

Methods:
We used Surveillance, Epidemiology, and End Results data from 18 U.S. regions in 2015 for 34 cancer sites to calculate crude and adjusted (using age- and sex-specific weights) mean ages at diagnosis. Differences in age at diagnosis comparing Hispanics to NHWs (δ) were assessed using independent sample t tests.

Results:
Crude mean ages at diagnosis were lower among Hispanic males and females for all sites combined and for most cancer sites. After age-adjustment, Hispanic (vs. NHW) males remained younger on average at diagnosis of chronic myeloid leukemia [δ = −6.1; 95% confidence interval (CI), −8.1 to −4.1 years], testicular cancer (δ =−4.7; 95% CI, −5.4 to −4.0), Kaposi sarcoma (δ =−3.6; 95% CI,−6.3 to −0.8), mesothelioma (δ =−3.0; 95% CI,−4.3 to −1.7), and anal cancer (δ =−2.4; 95% CI, −3.9 to −0.8), and older at diagnosis of gallbladder cancer (δ = +3.8; 95% CI, 1.8 to 5.7) and Hodgkin's lymphoma (δ = +7.5; 95% CI, 5.7 to 9.4), and Hispanic (vs. NHW) females remained younger at diagnosis of mesothelioma (δ = −3.7; 95% CI, −6.7 to −0.7) and gallbladder cancer (δ = −3.0; 95% CI, −4.3 to −1.7) and older at diagnosis of skin cancer (δ = +3.8; 95% CI, 3.1 to 4.5), cervical cancer (δ = +4.1; 95% CI, 3.3 to 4.8), and Hodgkin's lymphoma (δ = +7.0; 95% CI, 5.0 to 9.1).

Conclusions:
On average, Hispanics are diagnosed with cancer at younger ages than NHWs; however, for many cancers these differences reflect the younger age structure in Hispanics.

Impact:
Population age structure should be considered when comparing age at cancer diagnosis across racial/ethnic groups.
A Randomized, Phase III Study of Lenvatinib in Chinese Patients with Radioiodine-Refractory Differentiated Thyroid Cancer
Authors: Zheng Xiangqian , Xu Zhengang , Ji Qinghai , Ge Minghua , Shi Feng , Qin Jianwu , Wang Feng , Chen Guang , Zhang Yuan , Huang Rui , Tan Jian , Huang Tao , Li Sijin , Lv Zhongwei , Lin Yansong , Guo Zhuming , Kubota Tomoki , Suzuki Takuya , Ikezawa Hiroki , Gao Ming 
Published: July 2021

Abstract

Purpose:
Lenvatinib has shown efficacy in treating radioiodine-refractory differentiated thyroid cancer (RR-DTC) in the multinational phase III SELECT study; however, it has not been tested in Chinese patients with RR-DTC.

Patients and Methods:
Chinese patients with confirmed RR-DTC (n = 151) were randomly assigned 2:1 to receive lenvatinib 24 mg/day or placebo in 28-day cycles. The primary endpoint was progression-free survival, and key secondary endpoints included objective response rate and safety. Analyses for progression-free survival and objective response rate were conducted using Response Evaluation Criteria in Solid Tumors v1.1 and confirmed by independent imaging review. All adverse events were assessed and monitored.

Results:
Progression-free survival was significantly longer with lenvatinib treatment [n = 103; median 23.9 months; 95% confidence interval (CI), 12.9–not estimable] versus placebo (n = 48; median 3.7 months; 95% CI, 1.9–5.6; hazard ratio = 0.16; 95% CI, 0.10–0.26; P &lt; 0.0001). The objective response rate was 69.9% (95% CI, 61.0–78.8) in the lenvatinib arm and 0% (95% CI, 0–0) in the placebo arm. At data cutoff, 60.2% of patients receiving lenvatinib remained on treatment; treatment-emergent adverse events led to lenvatinib discontinuation in 8.7% of patients. Overall, treatment-emergent adverse events of grade ≥3 occurred in 87.4% of patients in the lenvatinib arm, the most common being hypertension (62.1%) and proteinuria (23.3%).

Conclusions:
Lenvatinib at a starting dose of 24 mg/day significantly improved progression-free survival and objective response rate in Chinese patients with RR-DTC versus placebo. There were no new or unexpected toxicities. Results are consistent with those from SELECT involving patients with RR-DTC.
Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-cell Effector Functions and Proliferation
Authors: Lu Ting , Ma Rui , Li Zhenlong , Mansour Anthony G. , Teng Kun-Yu , Chen Li , Zhang Jianying , Barr Tasha , Caligiuri Michael A. , Yu Jianhua 
Published: July 2021

AbstractTrogocytosis is a fast, cell–cell contact-dependent uptake of membrane patches and associated molecules by one cell from another. Here, we report our investigation of trogocytosis of TYRO3, a cell membrane protein, from tumor target cells to natural killer (NK) cells and the associated functional consequences for NK cells. We found that although NK cells did not express endogenous TYRO3 on the cell surface, activated NK cells rapidly acquired TYRO3 from tumor cells via trogocytosis in vitro and in vivo. NK cells that acquired TYRO3, which we termed TYRO3+ NK cells, had significantly enhanced cytotoxicity and IFNγ production as well as higher expression of some activated surface markers compared with TYRO3− NK cells. Furthermore, the activation status of NK cells and TYRO3 expression levels on donor cells, either endogenous or ectopic, positively correlated with trogocytosis levels. When the antigen-presenting cell (APC) K562 leukemia cell line, a feeder cell line to expand NK cells, overexpressed TYRO3, TYRO3 was transferred to NK cells via trogocytosis, which improved NK-cell proliferation ex vivo. This provides a strategy to manufacture NK cells or their engineered counterparts, such as chimeric antigen receptor NK cells, for the treatment of cancer or infectious diseases.
Anti-dsDNA Antibodies Increase the Cardiovascular Risk in Systemic Lupus Erythematosus Promoting a Distinctive Immune and Vascular Activation
Authors: Patiño-Trives Alejandra María , Pérez-Sánchez Carlos , Pérez-Sánchez Laura , Luque-Tévar María , Ábalos-Aguilera M. Carmen , Alcaide-Ruggiero Lourdes , Arias-de la Rosa Iván , Román-Rodríguez Cristóbal , Seguí Pedro , Espinosa Mario , Font Pilar , Barbarroja Nuria , Escudero-Contreras Alejandro , Antonio González-Reyes José , Manuel Villalba José , Collantes-Estévez Eduardo , Aguirre-Zamorano M. Ángeles , López-Pedrera Chary 
Published: July 2021

Objective:
Systemic lupus erythematosus (SLE) is associated to boosted atherosclerosis development and a higher cardiovascular disease risk. This study aimed to delineate the role of anti-double stranded DNA (anti-dsDNA) antibodies on the molecular profile and the activity of immune and vascular cells, as well as on their enhanced cardiovascular risk.

Approach and Results:
Eighty SLE patients were included. Extensive clinical/analytical evaluation was performed, including cardiovascular disease parameters (endothelial function, proatherogenic dyslipidemia, and carotid intima-media thickness). Gene and protein expression profiles were evaluated in monocytes from patients diagnosed positive or negative for anti-dsDNA antibodies by using NanoString and cytokine arrays, respectively. NETosis and circulating inflammatory profile was assessed in both neutrophils and plasma. Positivity and persistence of anti-dsDNA antibodies in SLE patients were associated to endothelial dysfunction, proatherogenic dyslipidemia, and accelerated atherosclerosis. In parallel, anti-dsDNA antibodies were linked to the aberrant activation of innate immune cells, so that anti-dsDNA(+) SLE monocytes showed distinctive gene and protein expression/activity profiles, and neutrophils were more prone to suffer NETosis in comparison with anti-dsDNA(−) patients. Anti-dsDNA(+) patients further displayed altered levels of numerous circulating mediators related to inflammation, NETosis, and cardiovascular risk. In vitro, Ig-dsDNA promoted NETosis on neutrophils, apoptosis on monocytes, modulated the expression of inflammation and thrombosis-related molecules, and induced endothelial activation, at least partially, by FcR (Fc receptor)-binding mechanisms.

Conclusions:
Anti-dsDNA antibodies increase the cardiovascular risk of SLE patients by altering key molecular processes that drive a distinctive and coordinated immune and vascular activation, representing a potential tool in the management of this comorbidity.
Complete Revascularization in Patients Undergoing a Pharmacoinvasive Strategy for ST-Segment–Elevation Myocardial Infarction: Insights From the COMPLETE Trial
Authors: Dehghani Payam , Cantor Warren J. , Wang Jia , Wood David A. , Storey Robert F. , Mehran Roxana , Bainey Kevin R. , Welsh Robert C. , Rodés-Cabau Josep , Rao Sunil , Lavi Shahar , Velianou James L. , Natarajan Madhu K. , Ziakas Antonios , Guiducci Vincenzo , Fernández-Avilés Francisco , Cairns John A. , Mehta Shamir R. 
Published: July 2021

Background:
The COMPLETE trial (Complete Versus Culprit-Only Revascularization to Treat Multi-Vessel Disease After Early PCI for STEMI) demonstrated that staged nonculprit lesion percutaneous coronary intervention (PCI) reduced major cardiovascular events in patients with ST-segment–elevation myocardial infarction and multivessel coronary artery disease. It is unclear whether consistent benefit is observed in patients undergoing a pharmacoinvasive strategy compared with primary PCI.

Methods:
Following culprit lesion PCI, 4041 patients with ST-segment–elevation myocardial infarction and multivessel coronary artery disease were randomized to either routine nonculprit lesion PCI or culprit lesion only PCI. In a prespecified analysis, we determined the treatment effect in 303 patients undergoing a pharmacoinvasive strategy versus 3738 patients undergoing primary PCI on the first coprimary outcome of cardiovascular death or new myocardial infarction and the second coprimary outcome of cardiovascular death, new myocardial infarction, or ischemia-driven revascularization.

Results:

The first coprimary was reduced with complete revascularization both in the patients undergoing a pharmacoinvasive strategy (2.1%/y versus 4.7%/y, hazard ratio, 0.45 [95% CI, 0.21–0.97]) and in patients undergoing primary PCI (2.7%/y versus 3.6%/y, hazard ratio, 0.77 [95% CI, 0.62–0.95]; interaction
P
=0.18). The second coprimary outcome was reduced with complete revascularization in patients undergoing a pharmacoinvasive strategy (2.3%/y versus 8.5%/y, hazard ratio, 0.28 [95% CI, 0.14–0.56]), and in patients undergoing primary PCI (3.2%/y versus 6.0%/y, hazard ratio, 0.53 [95% CI, 0.44–0.64], interaction
P
=0.07).

Conclusions:
Among patients with ST-segment–elevation myocardial infarction and multivessel disease, complete revascularization with multivessel PCI consistently reduces major cardiovascular events in patients undergoing an initial pharmacoinvasive strategy as well as in those undergoing primary PCI.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01740479.
The Experience of Sound: An Interview with Thomas DeLio
Authors: Licata Thomas 
Published: July 2021

Abstract
Thomas DeLio is a composer and theorist of international renown in both fields and especially noted for his work in computer music. In this conversation he discusses his musical thinking with over 40 years in the field. His compositions have been performed worldwide and are recorded on numerous labels. Neuma recordings has recently released five volumes of his recorded compositions in an ongoing series of his collected works. The interview itself, conducted over a series of phone conversations in the summer of 2020, begins with a look at his early student years at the New England Conservatory of Music in the late 1960s and early 1970s and navigates through to his current work and thinking today. Numerous aspects of his compositional approach and aesthetics are discussed, including his early influences, his illuminating thoughts on time and silence in his music, his applications of various technologies, and spatial projection, particularly at it relates to his work with sound installations.
Research at Rome's Centro Ricerche Musicali on Interactive and Adaptive Installations and on Augmented Instruments
Authors: Lupone Michelangelo , Bianchini Laura , Lanzalone Silvia , Gabriele Alessio 
Published: July 2021

Abstract
Established in 1988 by composers Laura Bianchini and Michelangelo Lupone, the Centro Ricerche Musicali (CRM) in Rome was officially recognized in 1990 as a Music Research Center by the Ministry for University Education and Scientific and Technological Research. The Center focuses on musical production in relation to new technologies, in order to create a continual interaction among musical language, scientific thought, and technological resources. The staff at CRM, comprising musicians, technicians, visual artists, architects, information technology specialists, engineers, and researchers, aim to promote study of the aesthetic, analytical, and scientific aspects of music.
In the beginning, research at CRM concerned the design and development of specific hardware devices for live electronics and composition, such as the Fly10 (1983–1985) and Fly30 (1990) systems. Subsequent studies on a physical model for the bow-and-string system in 1997 gave rise to the development of virtual musical instruments. From 1999 onwards, other areas of research have included interactivity and adaptivity applied to musical forms, the development of specific technologies for sound art installations and sculptural–musical works, and augmented instruments such as the Feed-Drum, SkinAct, WindBack, and ResoFlute.
This article presents a brief history of CRM and some artistic productions by composers working at the Center.
History of Painters in Le Mousquetaire (1855)
Authors: Passignat Émilie 
Published: July 2021

Abstract
In Florence, where he stayed between 1840 and 1843, Alexandre Dumas received a very prestigious editorial commission, La Galerie de Florence, to illustrate the collection of the Grand Duke’s Gallery. Dumas produced a history of the Medici family, a history of painting from the Egyptians to the present, and Histoire des peintres. Several decades later he reprised some of these texts in Trois maîtres (1861) and Italiens et Flamands (1862), which profiled different painters. To understand Dumas’s selection of artists, we must consider an intermediate work of his that has so far been forgotten: his Histoire des peintres published in feuilleton format in the pages of Le Mousquetaire, a journal he founded and edited between 1853 and 1857. This study briefly sets out the history of this work, focuses on some elements of its commentary, and identifies it as an interesting case of pseudo-scientific popularization spread via new channels of mass communication.
Designing-With/In World Politics
Authors: Austin Jonathan Luke , Leander Anna 
Published: July 2021

Abstract
Why is the praxis of the International Social Sciences (iss) so limited? Why are word counts and abstracts so much more integral to our quotidian workday than datasheets or color palettes? Why do we do little more than write texts and give lectures with – perhaps – the odd foray into photography or film-making? Why are we so reluctant to practically (and so not simply conceptually) engage with the full gamut of material, aesthetic, and technological making? This essay addresses these questions by advocating for the emergence of an International Political Design. It begins from the intuition that conceptual and empirical shifts across iss towards embracing the material-entanglements of world politics, the centrality of affect and emotion to human praxis, and relational ontologies of emergence, prefiguration, and complexity, all logically demand a radical re-thinking of our praxis. Specifically, we argue that limiting our activities to the alphabetical (or visual) mediation of knowledge about world politics constrains our politicality and impoverishes our conceptual and empirical vitality. Considered in conjunction with the contemporary prevalence of global violence, injustice, and oppression, we suggest that integrating a far broader range of material-aesthetic practices into iss is now an ethical imperative. Without taking up that responsibility, we abdicate the possibility of a more worldly and socially-embedded social science. Based on these core contentions, our discussion elaborates on how we might imagine an International Political Design: a conceptually rich, empirically-grounded, and ‘applied’ material-aesthetic approach to iss. We do so in the form of a manifesto or – rather – collage of manifestos that each militates, in one way or another, towards the necessity of designing-with/in world politics.
Integrated Urban Environmental System of Systems for Weather Ready Cities in India
Authors: Kaginalkar Akshara , Ghude Sachin D. , Mohanty U. C. , Mujumdar Pradeep , Bhakare Sudheer , Darbari Hemant , Dwivedi Arun K. , Gavali Pallavi , Gavhale Srujan , Islam Sahidul , Kadam Gouri , Kedia Sumita , Khare Manoj , Kharkar Neelesh , Kulkarni Santosh H. , Meher Sri Sai , Nath A. K. , Niyaz Mohamed , Pokale Sagar , Valappil Vineeth Krishnan , Debnath Sreyashi , Jena Chinmay , Nadimpalli Raghu , Swain Madhusmita , Davis Saimy , Avinash Shubha , Kishtawal C. , Gargava Prashant , Attri S. D. , Niyogi Dev 
Published: July 2021

Abstract
Global urban population is projected to double by 2050. This rapid urbanization is the driver of economic growth but has environmental challenges. To that end, there is an urgent need to understand, simulate, and disseminate information about extreme events, routine city operations, and long-term planning decisions. This paper describes an effort underway in India involving an interdisciplinary community of meteorology, hydrology, air quality, and computer science from national and international institutes. The urban collaboratory is a system of systems for simulating weather, hydrology, air quality, health, energy, transport, and economy and its interactions. Study and prediction of urban events involve multiscale observations and cross-sector models, heterogeneous data management, and enormous computing power. The consortia program (NSM_Urban) is part of “weather ready cities,” under the aegis of India’s National Supercomputing Mission. The ecosystem “Urban Environment Science to Society” (UES2S) builds on the integrated cyberinfrastructure with a science gateway for community research and end-user service with modeling and interoperable data. The collaboratory has urban computing, stakeholder participation, and a coordinated means to scaffold projects and ideas into operational tools. It discusses the design and the utilization of high-performance computing (HPC) as a science cloud platform for bridging urban environment and data science, participatory stakeholder applications, and decision-making. The system currently integrates models for high-impact urban weather, flooding, air quality, and simulating street- and building-scale wind flow and dispersion. The program with the work underway is ripe for interfacing with regional and international partners, and this paper provides an avenue toward that end.
Interdecadal changes in the interannual variability of the summer temperature over Northeast Asia
Authors: Chen Ruidan , Wen Zhiping , Lu Riyu , Liu Wenjun 
Published: July 2021

AbstractThis study reveals the interdecadal changes in the interannual variability of the summer temperature over Northeast Asia (NEA), which presents an enhancement around the early 1990s and a reduction after the mid-2000s. The stronger NEA temperature variability after the early 1990s is favored by the enhanced influence of the Pacific–Japan (PJ) teleconnection, which is remotely modulated by the southeastern tropical Indian Ocean (SETIO). After the early 1990s, the mean state over the SETIO presents relatively warmer SST and ascending motion, favoring a good relationship between the local SST and convection. Therefore, the SETIO SST could prominently influence the local convection and subsequently modulate the convection over the western North Pacific (WNP) via a cross-equatorial overturning circulation. The abnormal convection over the WNP further triggers the PJ teleconnection to influence NEA. However, these ocean–atmosphere processes disappear before the early 1990s. In this period, the mean state over the SETIO features relatively colder SST and subsiding motion, accompanied by a poor relationship between the local SST and convection. Therefore, the variability of convection over the SETIO is weak, thus the atmospheric variability over the WNP is also weakened and the PJ teleconnection presents a different distribution that could not influence NEA. The reduced variability of NEA temperature after the mid-2000s is related to the feeble influence of the PJ teleconnection and the reduced variability of the SETIO SST, which is modulated by the SST over the tropical central–eastern Pacific during the preceding winter to spring.