bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature and precipitation seasonal forecasts over the Mediterranean region: added value compared to simple forecasting methods
Authors: Calì Quaglia Filippo , Terzago Silvia , von Hardenberg Jost 
Published: September 2021

AbstractThis study considers a set of state-of-the-art seasonal forecasting systems (ECMWF, MF, UKMO, CMCC, DWD and the corresponding multi-model ensemble) and quantifies their added value (if any) in predicting seasonal and monthly temperature and precipitation anomalies over the Mediterranean region compared to a simple forecasting method based on the ERA5 climatology (CTRL) or the persistence of the ERA5 anomaly (PERS). This analysis considers two starting dates, May 1st and November 1st and the forecasts at lead times up to 6 months for each year in the period 1993–2014. Both deterministic and probabilistic metrics are employed to derive comprehensive information on the forecast quality in terms of association, reliability/resolution, discrimination, accuracy and sharpness. We find that temperature anomalies are better reproduced than precipitation anomalies with varying spatial patterns across different forecast systems. The Multi-Model Ensemble (MME) shows the best agreement in terms of anomaly correlation with ERA5 precipitation, while PERS provides the best results in terms of anomaly correlation with ERA5 temperature. Individual forecast systems and MME outperform CTRL in terms of accuracy of tercile-based forecasts up to lead time 5 months and in terms of discrimination up to lead time 2 months. All seasonal forecast systems also outperform elementary forecasts based on persistence in terms of accuracy and sharpness.
Peripartal pain perception and pain therapy: introduction and validation of a questionnaire as a quality instrument
Authors: Linzbach A. , Nitschke D. , Rothaug J. , Komann M. , Weinmann C. , Schleußner E. , Meißner W. , Jimenez Cruz J. , Schneider U. 
Published: September 2021

Abstract
Background
Labor pain is difficult to measure. The aim of this proof-of-concept study is to implement and test a questionnaire assessing pain sensation during and after vaginal deliveries. Its key aspect is a highly standardized survey of patient-reported outcome (PRO) by staff not involved in routine care.

Methods
Between January and November 2015 339 women were assessed 24–48 h after spontaneous or operative-vaginal delivery of a singleton. German language skills were a prerequisite to participate. The test–retest reliability was calculated in 38 women 24–36 and 48–72 h postpartum between July and October 2017. Primiparae after spontaneous delivery and multiparae with no history of operative deliveries were compared in a subgroup analysis.

Results
Maximum labor pain and post-partum pain were reported a median of 9 [8–10] and 4 [3–6]. Higher ratings were associated with younger age, higher gestational ages, infant’s biometrics, and the duration of laboring.
Only regional analgesia tended to reduce pain perception (NRS 8 vs. 9). Higher-degree injuries were associated with less pain postpartum. The questionnaire proved to be reliable in most aspects (Cronbach's α > 0.6 for 19/21 questions) and showed an acceptable content and criterion validity (Cohen correlation >  ± 0.3, interrelation between items).

Conclusion
Labor is a very painful experience, irrespective of previous obstetric history. Ratings indicate inadequateness of treatment except for patients receiving preventive postoperative pain management. Systematic postpartum pain assessment, hence, is still a pending issue. Adjustments will be made concerning language skills and specific questions on effectiveness of analgesia otherwise good reliability and validity of the questionnaire were proven.
Determination of phase relations of the olivine–ahrensite transition in the Mg2SiO4–Fe2SiO4 system at 1740 K using modern multi-anvil techniques
Authors: Chanyshev Artem , Bondar Dmitry , Fei Hongzhan , Purevjav Narangoo , Ishii Takayuki , Nishida Keisuke , Bhat Shrikant , Farla Robert , Katsura Tomoo 
Published: September 2021

AbstractThe phase relations of iron-rich olivine and its high-pressure polymorphs are important for planetary science and meteoritics because these minerals are the main constituents of terrestrial mantles and meteorites. The olivine–ahrensite binary loop was previously determined by thermochemical calculations in combination with high-pressure experiments; however, the transition pressures contained significant uncertainties. Here we determined the binary loop of the olivine–ahrensite transition in the (Mg,Fe)2SiO4 system at 1740 K in the pressure range of 7.5–11.2 GPa using a multi-anvil apparatus with the pressure determined using in situ X-ray diffraction, compositional analysis of quenched run products, and thermochemical calculation. Based on the determined binary loop, a user-friendly software was developed to calculate pressure from the coexisting olivine and ahrensite compositions. The software is used to estimate the shock conditions of several L6-type chondrites. The obtained olivine–ahrensite phase relations can also be applied for precise in-house multi-anvil pressure calibration at high temperatures.
Gadoxetic acid uptake as a molecular imaging biomarker for sorafenib resistance in patients with hepatocellular carcinoma: a post hoc analysis of the SORAMIC trial
Authors: Öcal Osman , Rössler Daniel , Gasbarrini Antonio , Berg Thomas , Klümpen Heinz-Josef , Bargellini Irene , Peynircioglu Bora , van Delden Otto , Schulz Christian , Schütte Kerstin , Iezzi Roberto , Pech Maciej , Malfertheiner Peter , Sangro Bruno , Ricke Jens , Seidensticker Max 
Published: September 2021

Abstract
Purpose
Gadoxetic acid uptake on hepatobiliary phase MRI has been shown to correlate with ß-catenin mutation in patients with HCC, which is associated with resistance to certain therapies. This study aimed to evaluate the prognostic value of gadoxetic acid uptake on hepatobiliary phase MRI in patients with advanced HCC receiving sorafenib.

Methods
312 patients with available baseline hepatobiliary phase MRI images received sorafenib alone or following selective internal radiation therapy (SIRT) within SORAMIC trial. The signal intensity of index tumor and normal liver parenchyma were measured on the native and hepatobiliary phase MRI images, and relative tumor enhancement higher than relative liver enhancement were accepted as high gadoxetic acid uptake, and its prognostic value was assessed using univariate and multivariate Cox proportional hazard models.

Results
The median OS of the study population was 13.4 (11.8–14.5) months. High gadoxetic acid uptake was seen in 51 (16.3%) patients, and none of the baseline characteristics was associated with high uptake.
In univariate analysis, high gadoxetic acid uptake was significantly associated with shorter overall survival (10.7 vs. 14.0 months, p = 0.005). Multivariate analysis confirmed independent prognostic value of high gadoxetic acid uptake (HR, 1.7 [1.21–2.3], p = 0.002), as well as Child–Pugh class (p = 0.033), tumor diameter (p = 0.002), and ALBI grade (p = 0.015).

Conclusion
In advanced HCC patients receiving sorafenib (alone or combined with SIRT), high gadoxetic acid uptake of the tumor on pretreatment MRI, a surrogate of ß-catenin mutation, correlates with shorter survival. Gadoxetic acid uptake status might serve in treatment decision-making process.
Growth hormone treatment in the pre-transplant period is associated with superior outcome after pediatric kidney transplantation
Authors: Jagodzinski Celina , Mueller Sophia , Kluck Rika , Froede Kerstin , Pavičić Leo , Gellermann Jutta , Mueller Dominik , Querfeld Uwe , Haffner Dieter , Zivicnjak Miroslav 
Published: September 2021

AbstractBackgroundRecombinant human growth hormone (rhGH) is frequently used for treatment of short stature in children with chronic kidney disease (CKD) prior to kidney transplantation (KT). To what extent this influences growth and transplant function after KT is yet unknown.MethodsPost-transplant growth (height, sitting height, leg length) and clinical parameters of 146 CKD patients undergoing KT before the age of 8 years, from two German pediatric nephrology centers, were prospectively investigated with a mean follow-up of 5.56 years. Outcome in patients with (rhGH group) and without (non-prior rhGH group) prior rhGH treatment was assessed by the use of linear mixed-effects models.ResultsPatients in the rhGH group spent longer time on dialysis and less frequently underwent living related KT compared to the non-prior rhGH group but showed similar heightz-scores at the time of KT. After KT, steroid exposure was lower and increments in anthropometricz-scores were significantly higher in the rhGH group compared to those in the non-prior rhGH group, although 18% of patients in the latter group were started on rhGH after KT. Non-prior rhGH treatment was associated with a faster decline in transplant function, lower hemoglobin, and higher C-reactive protein levels (CRP). After adjustment for these confounders, growth outcome did statistically differ for sitting heightz-scores only.ConclusionsTreatment with rhGH prior to KT was associated with superior growth outcome in prepubertal kidney transplant recipients, which was related to better transplant function, lower CRP, less anemia, lower steroid exposure, and earlier maturation after KT.Graphical abstractA higher resolution version of the Graphical abstract is available as Supplementary information
Which scaling rule applies to large artificial neural networks
Authors: Végh János 
Published: September 2021

AbstractExperience shows that cooperating and communicating computing systems, comprising segregated single processors, have severe performance limitations, which cannot be explained using von Neumann’s classic computing paradigm. In his classic “First Draft,” he warned that using a “too fast processor” vitiates his simple “procedure” (but not his computing model!); furthermore, that using the classic computing paradigm for imitating neuronal operations is unsound. Amdahl added that large machines, comprising many processors, have an inherent disadvantage. Given that artificial neural network’s (ANN’s) components are heavily communicating with each other, they are built from a large number of components designed/fabricated for use in conventional computing, furthermore they attempt to mimic biological operation using improper technological solutions, and their achievable payload computing performance is conceptually modest. The type of workload that artificial intelligence-based systems generate leads to an exceptionally low payload computational performance, and their design/technology limits their size to just above the “toy” level systems: The scaling of processor-based ANN systems is strongly nonlinear. Given the proliferation and growing size of ANN systems, we suggest ideas to estimate in advance the efficiency of the device or application. The wealth of ANN implementations and the proprietary technical data do not enable more. Through analyzing published measurements, we provide evidence that the role of data transfer time drastically influences both ANNs performance and feasibility. It is discussed how some major theoretical limiting factors, ANN’s layer structure and their methods of technical implementation of communication affect their efficiency. The paper starts from von Neumann’s original model, without neglecting the transfer time apart from processing time, and derives an appropriate interpretation and handling for Amdahl’s law. It shows that, in that interpretation, Amdahl’s law correctly describes ANNs.
The atomic Hardy space for a general Bessel operator
Authors: Kania-Strojec Edyta 
Published: September 2021

AbstractWe study Hardy spaces associated with a general multidimensional Bessel operator $$\mathbb {B}_\nu $$

B
ν

. This operator depends on a multiparameter of type $$\nu $$
ν
that is usually restricted to a product of half-lines. Here we deal with the Bessel operator in the general context, with no restrictions on the type parameter. We define the Hardy space $$H^1$$

H
1

for $$\mathbb {B}_\nu $$

B
ν

in terms of the maximal operator of the semigroup of operators $$\exp (-t\mathbb {B}_\nu )$$

exp
(
-
t

B
ν

)

. Then we prove that, in general, $$H^1$$

H
1

admits an atomic decomposition of local type.
A new mathematical hull-form with 10-shape parameters for evaluation of ship response in waves
Authors: Matsui Sadaoki 
Published: September 2021

AbstractThis study presents a new mathematical hull-form that is expressed as an explicit function with 10 hull-form parameters, which is called the Matsui hull-form in this study. The proposed hull-form was developed by expanding the modified Wigley hull-form so that the following 10 hull-form parameters can be independently varied: main dimensions $$L$$
L
, $$B$$
B
, $$d$$
d
, fineness coefficients $${C}_{b}$$

C
b

, $${C}_{\mathrm{m}}$$

C
m

, $${C}_{\mathrm{w}}$$

C
w

, second moment of waterplane area coefficient $${C}_{\mathrm{w}2}$$

C

w
2

, longitudinal center of buoyancy LCB and floatation LCF, and a parameter $$\beta$$
β
related to anterior–posterior asymmetry. The main purpose of this hull-form is that it is utilized for the following two objects: the first is the simple evaluation of the seakeeping performance and wave loads in the early ship designing stage without any detailed offset data, and the second is a systematical study on the influence of a ship’s dimensions on the ship response in waves. This paper presents the derivation of the Matsui hull-form and the applicability of the proposed hull-from was confirmed by comparing the ship response in waves with the actual ships. Moreover, a sensitivity analysis of the ship response in waves was conducted as an example of the application of the proposed hull-form.
Machine Learning in the Differentiation of Soft Tissue Neoplasms: Comparison of Fat-Suppressed T2WI and Apparent Diffusion Coefficient (ADC) Features-Based Models
Authors: Hu Peian , Chen Lei , Zhou Zhengrong 
Published: September 2021

AbstractMachine learning has been widely used in the characterization of tumors recently. This article aims to explore the feasibility of the whole tumor fat-suppressed (FS) T2WI and ADC features-based least absolute shrinkage and selection operator (LASSO)-logistic predictive models in the differentiation of soft tissue neoplasms (STN). The clinical and MR findings of 160 cases with 161 histologically proven STN were reviewed, retrospectively, 75 with diffusion-weighted imaging (DWI withbvalues of 50, 400, and 800 s/mm2). They were divided into benign and malignant groups and further divided into training (70%) and validation (30%) cohorts. The MR FS T2WI and ADC features-based LASSO-logistic models were built and compared. The AUC of the FS T2WI features-based LASSO-logistic regression model for benign and malignant prediction was 0.65 and 0.75 for the training and validation cohorts. The model’s sensitivity, specificity, and accuracy of the validation cohort were 55%, 96%, and 76.6%. While the AUC of the ADC features-based model was 0.932 and 0.955 for the training and validation cohorts. The model’s sensitivity, specificity, and accuracy were 83.3%, 100%, and 91.7%. The performances of these models were also validated by decision curve analysis (DCA). The AUC of the whole tumor ADC features-based LASSO-logistic regression predictive model was larger than that of FS T2WI features (p = 0.017). The whole tumor fat-suppressed T2WI and ADC features-based LASSO-logistic predictive models both can serve as useful tools in the differentiation of STN. ADC features-based LASSO-logistic regression predictive model did better than that of FS T2WI features.
Möglichkeiten der Kontrazeption bei Übergewicht und Adipositas
Authors: El-Hadad Samia , Insam Charlene , Unterhuber Katharina , Merki-Feld Gabriele Susanne , Leeners Brigitte 
Published: September 2021

ZusammenfassungDie weltweit steigende Prävalenz von Übergewicht und Adipositas betrifft zunehmend Frauen im fertilen Alter. Ungewollte oder ungeplante Schwangerschaften treten bei Frauen mit Übergewicht häufiger auf, was sowohl auf die mangelnde Anwendung einer effektiven Kontrazeption als auch auf die pathophysiologischen Besonderheiten, die mit einem erhöhten Körperfettanteil einhergehen, zurückzuführen ist. Eine adäquate Kontrazeptionsberatung adipöser Frauen ist daher essenziell für ihre Gesundheit und Lebensqualität. Unter den kombinierten Kontrazeptiva stellen orale Präparate, die Ethinylestradiol und Levonorgestrel (LNG) enthalten, eine effiziente Option dar, vorausgesetzt, es bestehen zusätzlich zum erhöhten Body-Mass-Index (BMI) keine weiteren Risikofaktoren für kardiovaskuläre oder thrombembolische Ereignisse. Rein gestagene Präparate zeichnen sich durch ihre geringen gesundheitlichen Risiken aus. Die Angst vor einer weiteren Gewichtszunahme ist ein häufiger Grund für das Sistieren der Einnahme, wobei dieser Zusammenhang außer für Depot-Medoxyprogesteronacetat für die meisten Präparate wissenschaftlich nicht belegt wurde. Die Wirksamkeit intrauteriner Kontrazeptiva entfaltet sich unabhängig vom Körpergewicht. Als Notfallkontrazeption ist die Einlage eines kupferhaltigen Intrauterinpessars die sicherste Methode, jedoch erheblich aufwendiger und teurer als eine orale Notfallkontrazeption. Die orale Einnahme von Ulipristalacetat 30 mg ist aufgrund der potenteren Ovulationshemmung und der stärkeren Reduktion unerwünschter Schwangerschaften gegenüber LNG 1,5 mg zu bevorzugen.
The Precautionary Principle and Expert Disagreement
Authors: Elkin Lee 
Published: September 2021

AbstractThe Precautionary Principle is typically construed as a conservative decision rule aimed at preventing harm. But Martin Peterson (JME 33: 5–10, 2007; The ethics of technology: A geometric analysis of five moral principles, Oxford University Press, Oxford, 2017) has argued that the principle is better understood as an epistemic rule, guiding decision-makers in forming beliefs rather than choosing among possible acts. On the epistemic view, he claims there is a principle concerning expert disagreement underlying precautionary-based reasoning called the ecumenical principle: all expert views should be considered in a precautionary appraisal, not just those that are the most prominent or influential. In articulating the doxastic commitments of decision-makers under this constraint, Peterson precludes any probabilistic rule that might result in combining expert opinions. For combined or consensus probabilities are likely to provide decision-makers with information that is more precise than warranted. Contra Peterson, I argue that upon adopting a broader conception of probability, there is a probabilistic rule, under which expert opinions are combined, that is immune to his criticism and better represents the ecumenical principle.
Separate counselling services in Norwegian upper secondary schools. A possibility for a collective holistic approach?
Authors: Mathiesen Ida Holth , Gunnarsdottir Hulda Mjöll 
Published: September 2021

AbstractGuidance counsellors hold an important role in youth’s educational and vocational choices, well-being and future careers. Central Norwegian policy documents recommend dividing counselling practices in schools into two functions: (1) career guidance and (2) educational welfare guidance. Policy documents also promote a holistic view of the pupil and the value of safeguarding the pupils’ best interest. This study explores how counsellors interpret these potentially conflicting recommendations for counselling practice. Our findings indicate that counsellors act as street-level bureaucrats and interpret the recommendations in relation to professional values and local contexts. Our analysis reveals three perspectives on how separate forms of counselling can be practised. The first view suggests an integrated, holistic approach. The second suggests a collective holistic approach. The third view indicates a reductionistic approach to career guidance. Counsellors appear to base their views on occupational professionalism, with the ideal of guarding the pupils’ best interest at its centre. Hence, the different understandings of separate counselling services, a holistic approach and ofwhatis in the pupils’ best interest appear significant for implementing the policy recommendations in schools.
Exclusion regions for parameter-dependent systems of equations
Authors: Ponleitner Bettina , Schichl Hermann 
Published: September 2021

AbstractThis paper presents a new algorithm based on interval methods for rigorously constructing inner estimates of feasible parameter regions together with enclosures of the solution set for parameter-dependent systems of nonlinear equations in low (parameter) dimensions. The proposed method allows to explicitly construct feasible parameter sets around a regular parameter value, and to rigorously enclose a particular solution curve (resp. manifold) by a union of inclusion regions, simultaneously. The method is based on the calculation of inclusion and exclusion regions for zeros of square nonlinear systems of equations. Starting from an approximate solution at a fixed set p of parameters, the new method provides an algorithmic concept on how to construct a box $${\mathbf {s}}$$
s
around p such that for each element $$s\in {\mathbf {s}}$$

s
∈
s

in the box the existence of a solution can be proved within certain error bounds.
Is there a Mineral-Induced ‘Economic Euphoria’?: Evidence from Latin America
Authors: Fenton Villar Paul 
Published: September 2021

AbstractA development imperative emphasising the economic benefits of mineral extraction has led researchers to speculate about whether minerals inflate citizens’ economic expectations and, due to an upward shift in aspirations, cause a degree of dissatisfaction. Using survey data from 18 Latin American countries, this study finds evidence of the ‘euphoric effect’ of minerals materialising among household expectations concerning future changes in the economic situation of their country. Similarly, it also finds a positive and significant relationship with expectations concerning future changes in respondents’ personal economic situation. However, it does not detect a significant relationship between minerals and citizens’ life satisfaction.
Inverses of SBP-SAT Finite Difference Operators Approximating the First and Second Derivative
Authors: Eriksson Sofia 
Published: September 2021

AbstractThe scalar, one-dimensional advection equation and heat equation are considered. These equations are discretized in space, using a finite difference method satisfying summation-by-parts (SBP) properties. To impose the boundary conditions, we use a penalty method called simultaneous approximation term (SAT). Together, this gives rise to two semi-discrete schemes where the discretization matrices approximate the first and the second derivative operators, respectively. The discretization matrices depend on free parameters from the SAT treatment. We derive the inverses of the discretization matrices, interpreting them as discrete Green’s functions. In this direct way, we also find out precisely which choices of SAT parameters that make the discretization matrices singular. In the second derivative case, it is shown that if the penalty parameters are chosen such that the semi-discrete scheme is dual consistent, the discretization matrix can become singular even when the scheme is energy stable. The inverse formulas hold for SBP-SAT operators of arbitrary order of accuracy. For second and fourth order accurate operators, the inverses are provided explicitly.