bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enfisema lobar congénito. presentación de caso clínico
Authors: Terceros Machucha Lario , Lazarte Amaya Rossio Karen , Baldelomar Fuentes Micaela , Chucusea Martinez Noemi 
Published: February 2021

El enfisema lobar congénito (ELC), es una malformación pulmonar rara. Se trata de una sobre distención de uno o más lóbulos pulmonares. Las causas principales son la deficiencia del desarrollo del cartílago bronquial y la obstrucción bronquial de tipo valvular generalmente causada por estenosis bronquial idiopática. El tratamiento, en general es quirúrgico
Laboratorios de ingreso normales. Ecocardiografía: Dextro posición cardiaca en situs solitus por desplazamiento de una masa, CIV, FOP. Ecografía Diafragmática y abdominal normal.
Colon por enema: Marco colonico buen pasaje localizado en topografía habitual. TAC Tórax múltiples quistes en campo pulmonar izquierdo. Se realiza lobectomía inferior izquierda. Histopatología confirma enfisema lobar congénito. Es dado de alta a los 10 días posquirúrgico.
DEMOGRAPHIC VARIABLES ASSOCIATED WITH DRUG USE IN BIPOLAR PATIENTS
Authors: Rashid Aysha , Mariam Haroon  , Sumira Qambar Bokhari  , Aysha Butt  , Nauman Mazhar  , Ali Anjum  
Published: February 2021

Background: Substance Use is highly associated with bipolar affective disorder, however the reason for the co-occurrence is unknown. It was evident that if a bipolar patient use drug of abuse his outcome will be poor. Either it can directly trigger the affective symptoms, or may affect the treatment compliance indirectly.
Aims: The objective of this study was to study the demographic correlates of drug abuse in patients with bi-polar affective disorder.
Method: Cross-Sectional research design and non-probability consecutive sampling was used to collect data from a private clinic in Lahore. Data was comprised of 368 patients of bipolar disorder.
Results: Out of a total of 368 bipolar patients, drug abuse was found in 147 patients that is 39.9%. The results showed that the mean age of the patients was 31.03 ±5.837; mean monthly income was 229597.82 ±164626.77 PKR. The mean duration of illness was 6.54 ±5.157. The mean number of drugs used was 2 ±0.875. The mean cost of drug was 29945.7 ±19068.8 PKR. The mean number of hospitalization was 2.47 ±1.694. Association between drug use and occupation of bipolar patients (0.006), factors leading to initiation of drug use (0.000), family history of drug use (0.001), current episode (0.000) and the type of drugs used (0.000) was statistically significant.
Conclusion: The cause and effect relationship between drug use and bipolar disorder cannot be clearly identified. However occupation of the patient, reasons of initiating drugs, drug abuse in family, current episode as well as type of drugs used have significant association with drug abuse in bipolar patients .
HUBUNGAN PENERAPAN PEDOMAN GIZI SEIMBANG DENGAN STATUS GIZI BALITA USIA 36-60 BULAN DI PUSKESMAS KARANG KITRI BEKASI 2018
Authors: Simanjuntak Farida Mentalina 
Published: February 2021

Pendahuluan: Pedoman Gizi Seimbang telah dikenalkan dan disosialisasikan kepada masyarakat lebih dari 15 tahun lalu, namun masih banyak masalah gizi yang belum teratasi yaitu gizi lebih dan gizi kurang. Tujuan: Untuk mengetahui hubungan penerapan pedoman gizi seimbang dengan status gizi pada balita usia 36-60 bulan di wilayah Puskesmas Karang Kitri Bekasi Tahun 2018. Metode: Penelitian ini merupakan penelitian kuantitatif menggunakan metode studi analitik dengan pendekatan cross sectional dan dilakukan uji chi square. Pengambilan sampel menggunakan teknik purposive sampling yaitu, pengambilan sampel ditentukan berdasarkan kriteria-kriteria tertentu yang telah ditetapkan dan jumlah sampel 46 balita yang berusia 36-60 bulan. Hasil: Hasil penelitian ini menunjukan terdapat hubungan yang bermakna antara penerapan pedoman gizi seimbang dengan status gizi pada balita usia 36-60 bulan di Wilayah Puskesmas Karang Kitri Bekasi Tahun 2018 (Pvalue = 0,012). Kesimpulan: Terdapat hubungan yang signifikan antara penerapan pedoman gizi seimbang dengan status gizi pada balita usia 36-60 bulan di wilayah Puskesmas Karang Kitri (Pvalue = 0,012).
The Relationship Between Knowledge, Attitude And Hand Washing Behavior With Recurrent Typhoid Fever In Puskesmas Bojong Rawalumbu Bekasi 2019
Authors: Simamora Rotua Suriany 
Published: February 2021

Latar Belakang : Demam thypoid merupakan penyakit yang menyerang usus halus. Penyakit ini dipengaruhi oleh lingkungan, perilaku hidup bersih dan sehat, hygiene diri. Mencuci tangan merupakan salah satu cara yang paling efektif dan sering dilewatkan untuk mencegah penyebaran berbagai jenis infeksi dan penyakit baik di rumah, tempat kerja dan rumah sakit.
Tujuan : Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap dan perilaku mencuci tangan dengan demam thypoid berulang di Puskesmas Bojong Rawalumbu Bekasi.
Metode Penelitian : Metode penelitian ini menggunakan desain deskriptif analitik kolerasi dengan pendekatan crossectional study
Hasil Penelitian : Tidak ada hubungan antara pengetahuan dan sikap tentang mencuci tangan dengan kejadian thypoid berulang tetapi ada hubungan yang bermakna antara perilaku mencuci tangan dengan kejadian demam thypoid berulang di puskesmas bojong rawalumbu bekasi dengan nilai p value 0,006.
ANALISIS ANGKA KUMAN PADA TANGAN PEDAGANG LOTEK DI JALAN RAYA ANDALAS KOTA PADANG TAHUN 2020
Authors: Sari Mila 
Published: February 2021

Abstrak : Salah satu sumber kontaminasi makanan yang potensial adalah dari tangan tenaga penjamah. Berdasarkan pengamatan yang dilakukan pada pedagang lotek di jalan Raya Andalas, perilaku penjamah makanan kurang memperhatikan hygiene pada saat pengolahan lotek terutama pada hygiene tangan, pedagang tidak mencuci tangan dengan air mengalir sebelum mengolah makanan, prilaku pedagang yang langsung menyentuh bahan makanan tanpa perantara (sarung tangan) melainkan langsung dengan tangan, dan juga makanan yang dikonsumsi dalam keadaan mentah,. Hal ini dapat memungkinkan terjadinya kontaminasi kuman pada tangan terhadap lotek yang diolah oleh penjamah dan dapat beresiko terjadinya penyakit bagi konsumennya.Tujuan penelitian ini diketahuinya angka kuman pada tangan pedagang lotek di Jalan Raya Andalas Kota Padang Tahun 2020. Jenis penelitian ini adalah bersifat deskriptif. Populasi pada penelitian ini adalah pedagang lotek di Jalan Raya Andalas yang berjumlah 6 orang. Sampel pada penelitian ini adalah penjamah lotek di jalan Raya Andalas yaitu 5 orang. Pengumpulan data diperoleh dari pengamatan kondisi tangan dan pengambilan sampel kuman pada tangan pedagang kemudian dibawa ke laboratorium untuk di inkubasi selama 2x24 jam dan dihitung jumlah koloni kuman, pemeriksaan dilakukan di Laboratorium Kesehatan Lingkungan Poltekkes Kemenkes Padang. Hasil penelitian setelah dilakukan pemeriksaan pada tangan pedagang lotek terdapat 4 pedagang yang memenuhi syarat angka kuman pada tangan yaitu 89 CFU, 76 CFU, 63 CFU, 93 CFU dan 1 pedagang yang tidak memenuhi syarat angka kuman pada tangan yaitu 303 CFU.Diharapkan kepada pedagang hendaknya selalu memperhatikan kebersihan tangan seperti selalu cuci tangan pakai sabun setiap kontak dengan makanan, menggunakan alat bantu untk mengambil bahan makanan, tidak ada luka yang terbuka dan tidak memakai perhiasan (cincin).
Kata Kunci : Makanan jajanan; Angka Kuman
Pengujian Toksisitas Akut Pada Obat Bahan Alam
Authors: Reubun Yonathan Tri Atmodjo 
Published: February 2021

Uji toksisitas perlu dilakukan pada suatu produk obat yang akan dipasarkan. Uji awal (screening test) ini sangat penting secara farmakologi dan toksikologi karena akan digunakan untuk pertimbangan penentuan dosis, rentang waktu pemberian dan aplikasinya. Jamu merupakan sediaan obat tradisional yang sampai saat ini penggunaannya masih dibutuhkan oleh masyarakat di Indonesia. Metode pengujian toksisitas yang dipilih berdasarkan pedoman Organisation for Economic Co-operation and Development (OECD). Metode ini merupakan metode standar yang diakui oleh banyak negara. Eropa yang merupakan anggota dari OECD. Kelebihan utama metode ini adalah sedikitnya penggunaan hewan pengerat serta waktu ujinya yang relatif cepat dengan berprinsip pada 3R. Pada review jurnal didapatkan beberapa hasil LD50 pada berbagai tanaman yaitu 0,2g/kg BB, 2g/kg BB, 3,91 g/kgBB, 3,91 g/kgBB, 4.9g/kgBB, 5g/kg BB, 16g/kg BB, dan 22,41 g/kg BB. Kesimpulan dari pengujian ini adalah nilai dosis toksik jamu adalah > 50-300 mg/kg bb seperti disebutkan dalam Annex 2c: OECD/OCE.
PENGARUH IMPLEMENTASI ECLECTIC METHOD TERHADAP PRESTASI BELAJAR SISWA PADA PEMBELAJARAN BAHASA ARAB
Authors: Salbiah  
Published: February 2021

Sering ditemukannya keluhan beberapa siswa mengenai kesulitan dalam mempelajari bahasa Arab baik dalam keterampiran mendengar (مَهَارَةُ الْإِسْتِمَاعِ), keterampilan berbicara (مَهَارَةُ الْكَلَامِ), keterampilan membaca (مَهَارَةُ الْقِرَاءَةِ), dan keterampilan menulis (مَهَارَةُ الْكِتَابَةِ)Penelitian ini bertujuan untuk menguji pengaruh implementasi Eclectic Method (طَرِيْقَةُ الْاِنْتِقَائِيَةِ) terhadap pembelajaran bahasa Arab siswa. Hasil dari penyelesaian uji t pre-test dan post-test one group desaign di atas menunjukkan bahwa thitung > ttabel dengan taraf signifikan 5 % atau 0,05, yaitu 8,46 > 2,064. Maka dengan hasil tersebut dapat peneliti simpulkan bahwa Ho ditolak dan Ha diterima. Adanya pengaruh yang signifikan antara implementasi Eclectic method terhadap pembelajaran bahasa Arab siswa.
Mencermati Teologi Reformed dan Gerakan Reformed Injili
Authors: Hadi P. Sahardjo  
Published: February 2021

Perkembangan doktrin dan Teologi Reformed yang sudah berlangsung lebih dari lima abad, telah menjadi sebuah tonggak sejarah dalam sejarah gereja dan kekristenan. Harus diakui bahwa Gerakan Reformasi telah menjadi bukti bahwa Tuhan masih memakai orang-orang yang dipilih-Nya untuk meluruskan pengajaran dan doktrin-doktrin yang sudah diselewengkan oleh gereja pada saat itu. Nama-nama seperti: Martin Luther, Phillip Melanchthon, Ulrich Zwingli, Johannes Calvin, dan lain-lain tercatat sebagai reformator dalam tradisi Calvinis. Tuhan berkarya, tetapi manusia terpilih telah dijadikan sebagai penegak kebenaran firman yang harus dikumandangkan.
A Clinicopathologic Evaluation of Follicular Lymphoma Grade 3A Versus Grade 3B Reveals No Survival Differences
Authors: Hsi Eric D. , Mirza Imran , Lozanski Gerard , Hill John , Pohlman Brad , Karafa Matthew T. , Coupland Robert 
Published: February 2021

Abstract
Context.—The World Health Organization classification recommends categorizing grade 3 follicular lymphomas based on the presence of centrocytes (grade 3A) or of sheets of centroblasts (grade 3B). The clinical significance of this practice is not known.
Objective.—To determine whether grade 3 follicular lymphoma subtype is associated with prognosis.
Design.—Multi-institutional retrospective case series.
Main Outcome Measure.—Overall survival.
Results.—Forty-five cases of grade 3 follicular lymphoma without diffuse large B-cell lymphoma were studied (35 cases of grade 3A, 10 cases of grade 3B) from 21 men and 24 women (median age, 67 years; mean age, 63.8 years; range, 26–86 years). Follow-up information from the time of diagnosis was available in all patients, with a median follow-up time of 24 months (mean, 34 months; range, 2– 115 months). Treatment information was available in 40 patients. There was no difference in age (P = .45, Wilcoxon test) or stage (P = .76, Fisher exact test) between patients with follicular lymphoma of grade 3A or grade 3B. Furthermore, the Cochran-Armitage test for trends showed no evidence that the proportion of patients with follicular lymphoma grade 3A or 3B increased or decreased with increasing stage at presentation. Kaplan-Meier analysis showed a median overall survival of 44 months from the time grade 3 follicular lymphoma was diagnosed, with no significant difference between cases diagnosed as grade 3A or grade 3B (P = .14, log-rank test). Univariable Cox proportional hazards modeling showed no evidence that an anthracycline-containing chemotherapy regimen or history of lower grade follicular lymphoma affected overall survival.
Conclusions.—In this retrospective series, subclassification of grade 3 follicular lymphoma into type 3A and 3B categories had limited clinical and prognostic significance. However, the study was limited by lack of statistical power. Since morphology often provides clues for progress in defining biologic differences, subtyping may still be useful, particularly in the setting of prospective clinical studies.
Noninvasive Carcinoma of the Breast: Angiogenesis and Cell Proliferation
Authors: Cao Ying , Paner Gladell P. , Kahn Leonard B. , Rajan Prabha B. 
Published: February 2021

Abstract
Context.—Angiogenesis and the cell proliferation index can predict the prognosis of invasive breast carcinoma; however, little is known of their roles in noninvasive tumor.
Objective.—To investigate the correlation of microvessel density and cell proliferation index with other histologic parameters (histologic type, nuclear grade, and mitotic count) in 65 cases of noninvasive carcinoma of the breast.
Design.—Formalin-fixed, paraffin-embedded tissues from 65 cases of carcinoma in situ of the breast were immunostained with antibody against factor VIII antigen and proliferation-associated nuclear antigen MIB-1. The microvessel density was measured by counting the total number of microvessels around the carcinoma in situ per 10 low-power microscopic fields. The cell proliferation index was calculated by counting MIB-1–positive nuclei in 100 tumor cells. A χ2 test and Spearman rank correlation test were used for statistical analysis.
Results.—The microvessel density and cell proliferation index of comedo-type, high-nuclear-grade ductal carcinomas in situ are significantly higher than those of either noncomedo type ductal carcinomas in situ or lobular carcinoma in situ (P &lt; .001).
Conclusions.—Angiogenesis and the cell proliferation index are active biological processes and may be considered as markers to separate low- and high-risk patients with noninvasive breast carcinomas.
Sinusoidal Dilatation and Congestion in Liver Biopsy: Is It Always Due to Venous Outflow Impairment?
Authors: Kakar Sanjay , Kamath Patrick S. , Burgart Lawrence J. 
Published: February 2021

Abstract
Context.—Impairment of venous outflow manifests as zone 3 sinusoidal dilatation and congestion (SDC) in liver biopsy. However, the finding of SDC is not specific for venous outflow impairment.
Objectives.—To determine the specificity of SDC in liver biopsies for venous outflow impairment and to seek an explanation for SDC in patients without clinical or radiologic features of venous outflow impairment.
Design.—Liver biopsies from 51 patients with sinusoidal dilatation were reviewed. Biopsies from transplant recipients, patients with cirrhosis, and patients with hepatic neoplasms (primary or metastatic) were not included. Clinical records were reviewed for laboratory tests and final clinicopathologic diagnosis.
Results.—Thirty-four patients (66.7%) had confirmed venous outflow impairment. Of the 17 cases (33.3%) without clinical and/or radiologic evidence of venous outflow impairment, vascular causes were present in 5 cases (9.8%; nodular regenerative hyperplasia in 2 cases and portal vein thrombosis, congenital absence of the portal vein, and sickle cell anemia in 1 case each). Systemic inflammatory disorders were identified in 6 patients (11.8%). These included 2 cases of Castleman disease and 1 each of sarcoidosis, Crohn disease, rheumatoid arthritis, and Still disease. Three patients (5.9%) had tumors without direct involvement of the liver (1 case each of Hodgkin lymphoma, renal cell carcinoma, and pancreatic serous pseudopapillary tumor). In the remaining 3 patients, SDC was identified in wedge liver biopsies performed at the time of surgery, including gastric bypass surgery, cholecystectomy, and splenectomy. No other disease association was apparent in these cases.
Conclusion.—Sinusoidal dilatation and congestion in liver biopsy is associated with venous outflow impairment in two thirds of the cases. In the absence of clinical and/or radiological evidence of venous outflow, diagnostic considerations include other vascular conditions, such as portal vein insufficiency and nodular regenerative hyperplasia. Sinusoidal dilatation and congestion can also occur in the setting of systemic inflammatory diseases, granulomatous disorders, and neoplasms, as well as in wedge biopsies obtained during abdominal surgery.
Xanthogranulomatous Funiculitis and Orchiepididymitis: Report of 2 Cases With Immunohistochemical Study and Literature Review
Authors: Nistal Manuel , Gonzalez-Peramato Pilar , Serrano Alvaro , Regadera Javier 
Published: February 2021

Abstract
Two patients with xanthogranulomatous inflammation are described, one with involvement of the spermatic cord and the other with 1 testicle and epididymis affected. To our knowledge, only 12 cases of xanthogranulomatous orchiepididymitis have been reported previously, one of which also presented a xanthogranulomatous funiculitis. Clinically, our patients presented with spermatic cord enlargement (case 1) and chronic orchitis that did not respond to treatment with antibiotics (case 2). Histopathologically, both cases showed extensive xanthogranulomatous inflammation with numerous foamy macrophages that were associated with colonies of microorganisms suggestive of actinomyces in case 1. Additionally, Escherichia coli was cultured from the surgical specimen of case 2. The possible underlying pathology may be diabetes in case 1 and phlebitis associated with chronic orchitis in case 2. Differential diagnoses with other lesions that are rich in macrophages, such as malakoplakia, and those testicular neoplasms without serologic tumor markers are discussed.
Atypical Angiomyolipoma of Kidney in a Patient With Tuberous Sclerosis: A Case Report With p53 Gene Mutation Analysis
Authors: Ma Linglei , Kowalski Diane , Javed Khurram , Hui Pei 
Published: February 2021

Abstract
Angiomyolipoma (AML) is the most common benign mesenchymal tumor of the kidney. It belongs to the family of perivascular epithelioid cell tumors and is typically composed of blood vessels, adipose tissue, and smooth muscle– like cells, which are characteristically positive for HMB-45. Results of recent studies suggest that p53 mutation may play an important role in AML progression. Here, we describe a locally destructive renal AML in a patient with tuberous sclerosis. The tumor consisted of mostly epithelioid cells with marked nuclear pleomorphism and frequent mitoses and was positive for HMB-45. The diagnosis of atypical epithelioid AML was made. Codon alteration in the p53 gene was not detected, despite focal p53 immunoreactivity and single nucleotide polymorphism at exon 6. Our finding indicates no definite link between p53 abnormalities and the atypical appearance of AML. To the best of our knowledge, this is the second renal AML case investigated for p53 mutations.
Swyer-James (MacLeod) Syndrome With Placental Transmogrification of the Lung: A Case Report and Review of the Literature
Authors: Marchevsky Alberto M. , Guintu Rogelio , Koss Michael , Fuller Clark , Houck Ward , McKenna Robert J. 
Published: February 2021

Abstract
Swyer-James (MacLeod) syndrome is an acquired form of unilateral hyperlucency of the lung and is characterized by the development of severe emphysema, bronchiectasis, and/or bronchiolitis obliterans. It may develop as a complication of repeated episodes of pulmonary infection resulting in bronchiolitis obliterans and obstruction of small airways. Most patients with Swyer-James (MacLeod) syndrome can be managed clinically, and the pathologic features of the syndrome have been described in only a few reports. Placental transmogrification of the lung is a rare histopathologic finding that has been described in patients with severe emphysema associated with cigarette smoking, congenital bullous emphysema, and fibrochondromatous hamartomas of the lung and is characterized by the development of peculiar structures in the pulmonary parenchyma that resemble placental villi. To our knowledge, placental transmogrification of the lung has not been previously described in patients with Swyer-James (MacLeod) syndrome. We encountered a 32-year-old man with a history of childhood asthma who presented with progressively severe exertional dyspnea and had unilateral right lung hyperlucency. The patient underwent a right pneumonectomy. Examination of the lung revealed severe mixed centriacinar-panacinar emphysema in all lobes, bullous emphysema in the upper lobe, bronchiectases, mild interstitial pneumonia with fibrosis, and placental transmogrification of the pulmonary parenchyma of all 3 lobes. Here, we review the pathology of Swyer-James (MacLeod) syndrome and the possible pathogenesis of villous-like changes in the lung tissues.
Perivascular Epithelioid Cell Tumor of the Oral Mucosa
Authors: Koutlas Ioannis G. , Pambuccian Stefan E. , Jessurun Jose , Manivel J. Carlos , Gopalakrishnan Rajaram 
Published: February 2021

Abstract
Perivascular epithelioid cell tumors (PEComas) are a family of tumors defined by the coexpression of melanocytic and muscle markers. Examples have been reported in many organs, soft tissues, and bone. Further expanding the list of locations, we report a case arising in the hard palate. Histologically, the tumor was composed of large elongated or epithelioid cells with granular cytoplasm. Immunohistochemically, tumor cells were positive for HMB-45, Melan A/MART-1, CD10, smooth muscle actin, desmin, and calponin. Ultrastructural examination revealed stage I melanosomes, thin filaments, and dense plaques. Recurrence has not been reported after 20 months. To our knowledge, this is the first detailed description of an intraoral PEComa.
Haemophilus influenzaeLymphadenopathy in a Patient With Agammaglobulinemia: Clinical-Histologic-Microbiologic Correlation and Review of the Literature
Authors: Black Candice , Zavod Matthew B. , Gosselin Benoit J. 
Published: February 2021

AbstractAgammaglobulinemia is the most common primary immunodeficiency, with an incidence of approximately 1 in 250 000 males in the United States. These patients are at risk for frequent recurrent infections, which may become fatal if untreated. Patients have increased susceptibility to encapsulated pyogenic bacteria. Haemophilus influenzae is second only to Streptococcus pneumoniae as the bacteria most frequently implicated in infections in these patients. We present a case involving an adolescent boy with X-linked agammaglobulinemia and H influenzae cervical adenopathy, confirmed twice by culture. We correlate the clinical, microbiologic, and histologic findings. Owing to the severity of infections in this population, surgical intervention is more common than in the immunocompetent population. This description may help the pathologist in considering a differential diagnosis when examining a diagnostic lymph node biopsy in these patients.