bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conic tangents based high precision extraction method of concentric circle centers and its application in camera parameters calibration
Authors: Hao Fei , Su Jinjiang , Shi Jingjing , Zhu Chaohan , Song Jiatong , Hu Yuntao 
Published: October 2021

AbstractA high-precision camera intrinsic parameters calibration method based on concentric circles was proposed. Different from Zhang’s method, its feature points are the centers of concentric circles. First, the collinearity of the projection of the center of concentric circles and the centers of two ellipses which are imaged from the concentric circles was proved. Subsequently, a straight line passing through the center of concentric circles was determined with four tangent lines of concentric circles. Finally, the projection of the center of concentric circles was extracted with the intersection of the straight line and the line determined by the two ellipse centers. Simulation and physical experiments are carried out to analyze the factors affecting the accuracy of circle center coordinate extraction and the results show that the accuracy of the proposed method is higher. On this basis, several key parameters of the calibration target design are determined through simulation experiments and then the calibration target is printed to calibrate a binocular system. The results show that the total reprojection error of the left camera is reduced by 17.66% and that of the right camera is reduced by 21.58% compared with those of Zhang’s method. Therefore, the proposed calibration method has higher accuracy.
Integrated study on the comprehensive magnetic-field configuration performance in the 150 kW superconducting magnetoplasmadynamic thruster
Authors: Zheng Jinxing , Liu Haiyang , Song Yuntao , Zhou Cheng , Li Yong , Li Ming , Tang Haibin , Wang Ge , Cong Yuntian , Wang Baojun , Wang Yibai , Wu Peng , Qu Timing , Zhu Xiaoliang , Zhu Lei , Liu Fei , Cheng Yuan , Zhao Boqiang 
Published: October 2021

AbstractHigher magnetic fields are always favoured in the magnetoplasmadynamic thruster (MPDT) due to its superior control of the plasma profile and acceleration process. This paper introduces the world's first integrated study on the 150 kW level AF-MPDT equipped with a superconductive coil. A completely new way of using superconducting magnet technology to confine plasma with high energy and extremely high temperatures is proposed. Using the PIC method of microscopic particle simulation, the plasma magnetic nozzle effect and performance of the MPDT under different magnetic-field conditions were studied. The integrated experiment used demonstrated that, in conjunction with the superconducting coil, greater homogeneity and a stronger magnetic field not only caused more even cathode ablation and improved its lifespan but also improved the performance of the MPDT (maximum thrust was 4 N at 150 kW, 0.56 T). Maximum thrust efficiency reached 76.6% and the specific impulse reached 5714 s.
Convolutional neural network for human cancer types prediction by integrating protein interaction networks and omics data
Authors: Chuang Yi-Hsuan , Huang Sing-Han , Hung Tzu-Mao , Lin Xiang-Yu , Lee Jung-Yu , Lai Wen-Sen , Yang Jinn-Moon 
Published: October 2021

AbstractMany studies have proven the power of gene expression profile in cancer identification, however, the explosive growth of genomics data increasing needs of tools for cancer diagnosis and prognosis in high accuracy and short times. Here, we collected 6136 human samples from 11 cancer types, and integrated their gene expression profiles and protein–protein interaction (PPI) network to generate 2D images with spectral clustering method. To predict normal samples and 11 cancer tumor types, the images of these 6136 human cancer network were separated into training and validation dataset to develop convolutional neural network (CNN). Our model showed 97.4% and 95.4% accuracies in identification of normal versus tumors and 11 cancer types, respectively. We also provided the results that tumors located in neighboring tissues or in the same cell types, would induce machine make error classification due to the similar gene expression profiles. Furthermore, we observed some patients may exhibit better prognosis if their tumors often misjudged into normal samples. As far as we know, we are the first to generate thousands of cancer networks to predict and classify multiple cancer types with CNN architecture. We believe that our model not only can be applied to cancer diagnosis and prognosis, but also promote the discovery of multiple cancer biomarkers.
Economical droplet-based microfluidic production of [18F]FET and [18F]Florbetaben suitable for human use
Authors: Lisova Ksenia , Wang Jia , Hajagos Tibor Jacob , Lu Yingqing , Hsiao Alexander , Elizarov Arkadij , van Dam R. Michael 
Published: October 2021

AbstractCurrent equipment and methods for preparation of radiopharmaceuticals for positron emission tomography (PET) are expensive and best suited for large-scale multi-doses batches. Microfluidic radiosynthesizers have been shown to provide an economic approach to synthesize these compounds in smaller quantities, but can also be scaled to clinically-relevant levels. Batch microfluidic approaches, in particular, offer significant reduction in system size and reagent consumption. Here we show a simple and rapid technique to concentrate the radioisotope, prior to synthesis in a droplet-based radiosynthesizer, enabling production of clinically-relevant batches of [18F]FET and [18F]FBB. The synthesis was carried out with an automated synthesizer platform based on a disposable Teflon-silicon surface-tension trap chip. Up to 0.1 mL (4 GBq) of radioactivity was used per synthesis by drying cyclotron-produced aqueous [18F]fluoride in small increments directly inside the reaction site. Precursor solution (10 µL) was added to the dried [18F]fluoride, the reaction chip was heated for 5 min to perform radiofluorination, and then a deprotection step was performed with addition of acid solution and heating. The product was recovered in 80 µL volume and transferred to analytical HPLC for purification. Purified product was formulated via evaporation and resuspension or a micro-SPE formulation system. Quality control testing was performed on 3 sequential batches of each tracer. The method afforded production of up to 0.8 GBq of [18F]FET and [18F]FBB. Each production was completed within an hour. All batches passed quality control testing, confirming suitability for human use. In summary, we present a simple and efficient synthesis of clinically-relevant batches of [18F]FET and [18F]FBB using a microfluidic radiosynthesizer. This work demonstrates that the droplet-based micro-radiosynthesizer has a potential for batch-on-demand synthesis of 18F-labeled radiopharmaceuticals for human use.
Multilayer radiation shield for satellite electronic components protection
Authors: Daneshvar Hamideh , Milan Kavoos Ghordoei , Sadr Ali , Sedighy Seyed Hassan , Malekie Shahryar , Mosayebi Armin 
Published: October 2021

AbstractIn this paper, various multi-layer shields are designed, optimized, and analyzed for electron and proton space environments. The design process is performed for various suitable materials for the local protection of sensitive electronic devices using MCNPX code and the Genetic optimization Algorithm. In the optimizations process, the total ionizing dose is 53.3% and 72% greater than the aluminum shield for proton and electron environments, respectively. Considering the importance of the protons in the LEO orbits, the construction of the shield was based on designing a proton source. A sample shield is built using a combination of Aluminum Bronze and molybdenum layers with a copper carrier to demonstrate the idea. Comparisons of radiation attenuation coefficient results indicate a good agreement between the experimental, simulation, and analytical calculations results. The good specifications of the proposed multi-layer shield prove their capability and ability to use in satellite missions for electronic device protection.
A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model
Authors: Schumacher David , Liehn Elisa A. , Nilcham Pakhwan , Mayan David Castaño , Rattanasopa Chutima , Anand Kaviya , Crespo-Avilan Gustavo E. , Hernandez-Resendiz Sauri , Singaraja Roshni R. , Cook Stuart A. , Hausenloy Derek J. 
Published: October 2021

AbstractVascular restenosis remains a major problem in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). Neointimal hyperplasia, defined by post-procedure proliferation and migration of vascular smooth muscle cells (VSMCs) is a key underlying pathology. Here we investigated the role of Interleukin 11 (IL-11) in a mouse model of injury-related plaque development. Apoe−/− mice were fed a hyperlipidaemic diet and subjected to carotid wire injury of the right carotid. Mice were injected with an anti-IL11 antibody (X203), IgG control antibody or buffer. We performed ultrasound analysis to assess vessel wall thickness and blood velocity. Using histology and immunofluorescence approaches, we determined the effects of IL-11 inhibition on VSMC and macrophages phenotypes and fibrosis. Treatment of mice with carotid wire injury using X203 significantly reduced post-endothelial injury vessel wall thickness, and injury-related plaque, when compared to control. Immunofluorescence staining of the injury-related plaque showed that X203 treatment did not reduce macrophage numbers, but reduced the number of VSMCs and lowered matrix metalloproteinase 2 (MMP2) levels and collagen content in comparison to control. X203 treatment was associated with a significant increase in smooth muscle protein 22α (SM22α) positive cells in injury-related plaque compared to control, suggesting preservation of the contractile VSMC phenotype. Interestingly, X203 also reduced the collagen content of uninjured carotid arteries as compared to IgG, showing an additional effect on hyperlipidemia-induced arterial remodeling in the absence of mechanical injury. Therapeutic inhibition of IL-11 reduced vessel wall thickness, attenuated neointimal hyperplasia, and has favorable effects on vascular remodeling following wire-induced endothelial injury. This suggests IL-11 inhibition as a potential novel therapeutic approach to reduce arterial stenosis following revascularization in CAD and PAD patients.
Cardiometabolic syndrome and associated factors among Ethiopian public servants, Addis Ababa, Ethiopia
Authors: Geto Zeleke , Challa Feyissa , Lejisa Tadesse , Getahun Tigist , Sileshi Meron , Nagasa Bikila , Tolcha Yosef , Daniel Yeabkal , Getnet Misrak , Molla Meseret Derbew , Degef Maria , Bekele Abebe , Seifu Daniel 
Published: October 2021

AbstractNon-communicable diseases (NCDs) are increasingly becoming the global cause of premature death encompassing cardiovascular diseases (CVDs), cancer, respiratory diseases and diabetes mellitus. However, cardiometabolic risk factors in the general population, especially among the high-risk groups have rarely been assessed in Ethiopia. The study aimed to assess the prevalence of metabolic syndrome, its components and associated factors among staff in the Ethiopian Public Health Institute (EPHI). An institutional-based cross-section study was conducted from March to June 2018 among EPHI staff members. A total of 450 study participants were involved in the study, and the World Health Organization NCD STEPS survey instrument version 3.1 was used for the assessment. The biochemical parameters were analyzed by using COBAS 6000 analyzer. Statistical package for the social science (SPSS) version 20 was used for data analysis. Both bivariate and multivariate logistic regression analyses were used to identify associated risk factors. p value < 0.05 was considered for statistical significance. The overall prevalence of metabolic syndrome was 27.6% and 16.7% according to IDF and NCEP criteria respectively, with males having greater prevalence than females (35.8% vs 19.4%). Central obesity, low high-density lipoprotein (HDL) and hypertension had a prevalence of 80.2%, 41.3%, and 23.6%, respectively. In multivariate analysis increasing age and having a higher body mass index (25–29.9) were significantly associated with metabolic syndromes. The magnitude of metabolic syndrome was relatively high among public employees. Preventive intervention measures should be designed on the modification of lifestyle, nutrition and physical activities, and early screening for early identification of cardiometabolic risks factors should be practised to reduce the risk of developing cardiovascular diseases.
Repeated exposure of the oral mucosa over 12 months with cold plasma is not carcinogenic in mice
Authors: Evert K. , Kocher T. , Schindler A. , Müller M. , Müller K. , Pink C. , Holtfreter B. , Schmidt A. , Dombrowski F. , Schubert A. , von Woedtke T. , Rupf S. , Calvisi D. F. , Bekeschus S. , Jablonowski L. 
Published: October 2021

AbstractPeri-implantitis may result in the loss of dental implants. Cold atmospheric pressure plasma (CAP) was suggested to promote re-osseointegration, decrease antimicrobial burden, and support wound healing. However, the long-term risk assessment of CAP treatment in the oral cavity has not been addressed. Treatment with two different CAP devices was compared against UV radiation, carcinogen administration, and untreated conditions over 12 months. Histological analysis of 406 animals revealed that repeated CAP exposure did not foster non-invasive lesions or squamous cell carcinoma (SCCs). Carcinogen administration promoted non-invasive lesions and SCCs. Molecular analysis by a qPCR screening of 144 transcripts revealed distinct inflammatory profiles associated with each treatment regimen. Interestingly, CAP treatment of carcinogen-challenged mucosa did not promote but instead left unchanged or reduced the proportion of non-invasive lesions and SCC formation. In conclusion, repeated CAP exposure of murine oral mucosa was well tolerated, and carcinogenic effects did not occur, motivating CAP applications in patients for dental and implant treatments in the future.
Radiologic-pathologic analysis of increased ethanol localization and ablative extent achieved by ethyl cellulose
Authors: Chelales Erika , Morhard Robert , Nief Corrine , Crouch Brian , Everitt Jeffrey I. , Sag Alan Alper , Ramanujam Nirmala 
Published: October 2021

AbstractEthanol provides a rapid, low-cost ablative solution for liver tumors with a small technological footprint but suffers from uncontrolled diffusion in target tissue, limiting treatment precision and accuracy. Incorporating the gel-forming polymer ethyl cellulose to ethanol localizes the distribution. The purpose of this study was to establish a non-invasive methodology based on CT imaging to quantitatively determine the relationship between the delivery parameters of the EC-ethanol formulation, its distribution, and the corresponding necrotic volume. The relationship of radiodensity to ethanol concentration was characterized with water–ethanol surrogates. Ex vivo EC-ethanol ablations were performed to optimize the formulation (n = 6). In vivo ablations were performed to compare the optimal EC-ethanol formulation to pure ethanol (n = 6). Ablations were monitored with CT and ethanol distribution volume was quantified. Livers were removed, sectioned and stained with NADH-diaphorase to determine the ablative extent, and a detailed time-course histological study was performed to assess the wound healing process. CT imaging of ethanol–water surrogates demonstrated the ethanol concentration-radiodensity relationship is approximately linear. A concentration of 12% EC in ethanol created the largest distribution volume, more than eight-fold that of pure ethanol, ex vivo. In vivo, 12% EC-ethanol was superior to pure ethanol, yielding a distribution volume three-fold greater and an ablation zone six-fold greater than pure ethanol. Finally, a time course histological evaluation of the liver post-ablation with 12% EC-ethanol and pure ethanol revealed that while both induce coagulative necrosis and similar tissue responses at 1–4 weeks post-ablation, 12% EC-ethanol yielded a larger ablation zone. The current study demonstrates the suitability of CT imaging to determine distribution volume and concentration of ethanol in tissue. The distribution volume of EC-ethanol is nearly equivalent to the resultant necrotic volume and increases distribution and necrosis compared to pure ethanol.
Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2
Authors: Takahata Yoshifumi , Hagino Hiromasa , Kimura Ayaka , Urushizaki Mitsuki , Kobayashi Sachi , Wakamori Kanta , Fujiwara Chika , Nakamura Eriko , Yu Kayon , Kiyonari Hiroshi , Bando Kana , Murakami Tomohiko , Komori Toshihisa , Hata Kenji , Nishimura Riko 
Published: October 2021

AbstractRunx2 is an essential transcription factor for bone formation. Although osteocalcin, osteopontin, and bone sialoprotein are well-known Runx2-regulated bone-specific genes, the skeletal phenotypes of knockout (KO) mice for these genes are marginal compared with those of Runx2 KO mice. These inconsistencies suggest that unknown Runx2-regulated genes play important roles in bone formation. To address this, we attempted to identify the Runx2 targets by performing RNA-sequencing and found Smoc1 and Smoc2 upregulation by Runx2. Smoc1 or Smoc2 knockdown inhibited osteoblastogenesis. Smoc1 KO mice displayed no fibula formation, while Smoc2 KO mice had mild craniofacial phenotypes. Surprisingly, Smoc1 and Smoc2 double KO (DKO) mice manifested no skull, shortened tibiae, and no fibulae. Endochondral bone formation was also impaired at the late stage in the DKO mice. Collectively, these results suggest that Smoc1 and Smoc2 function as novel targets for Runx2, and play important roles in intramembranous and endochondral bone formation.
A low-cost 2D WO3/Ni3S2 heterojunction for highly stable hydrogen evolution
Authors: Sun Tongming , Zhong Weiting , Zhang Mengke , Tang Yanfeng , Wang Jin , Xu Chen , Hu Lanping , Wang Minmin 
Published: October 2021

A WO3/Ni3S2 heterojunction electrode is developed, which exhibits higher electrical/ionic conductivity and catalytic activity and stability due to the specific cooperativity. It also shows high hydrogen evolution performance both at low and high current densities.
Directly written DPP-DTT/SrTiO3organic/inorganic heterojunctions for anisotropic self-powered photodetectors
Authors: Zhang Yong , Liu Weilin , Liu Yushen , Wang Conghuan , Zhu Guodong , Song Weidong 
Published: October 2021

Direct writing technique was developed to fabricate DPP-DTT/SrTiO3 photodetectors with parallel and perpendicular configurations, showing identical self-powered but anisotropic photoresponse, which exhibits great potential for broad applications.
Toward Preventing Speech and Language Disorders of Known Genetic Origin: First Post-Intervention Results of Babble Boot Camp in Children With Classic Galactosemia
Authors: Peter Beate , Davis Jennifer , Cotter Sarah , Belter Alicia , Williams Emma , Stumpf Melissa , Bruce Laurel , Eng Linda , Kim Yookyung , Finestack Lizbeth , Stoel-Gammon Carol , Williams Delaney , Scherer Nancy , VanDam Mark , Potter Nancy 
Published: October 2021

PurposeBabble Boot Camp (BBC) is a package of proactive activities and routines designed to prevent speech and language disorders in infants at predictable risk. It is implemented via parent training and currently undergoing clinical trial in children with a newborn diagnosis of classic galactosemia (CG), a metabolic disease with high risk of speech and language disorders. The purpose of this study is to provide updates to a previous pilot study and to present the first set of post-intervention results.MethodThe intervention and data collection occurred during child ages < 6–24 months, with follow-up assessments of speech and language at ages 2.5 and 3.5 years. Treatment targets included earliest vocalization rates, babble complexity, speech production accuracy, and vocabulary and syntactic growth. The oldest 15 children with CG (including three untreated controls) completed the first set of follow-up assessments. Aggregate data up to 10 months were available for 17 treated children with CG, six untreated children with CG, and six typical controls.ResultsAt ages 7–9 months, babbling complexity, as measured with mean babbling level, was higher in the treated children with CG than in the untreated children with CG and the typical controls. Prior to 24 months of age, the treated children with CG had greater expressive but not receptive vocabulary sizes than an untreated control. Follow-up testing showed typical language scores for all 12 treated children with CG and typical articulation scores for 11 of these, whereas one of three untreated children with CG had low articulation and expressive language scores.ConclusionsThe BBC appears to be a viable intervention to support the speech and expressive language development of children with GC. Future studies will evaluate the relative contributions of the earliest and later BBC components to outcomes.
Orbital obliquity sampling in the Kepler-20 system using the 3D animation software Blender
Authors: Müller H. M. , Ioannidis P. , Schmitt J. H. M. M. 
Published: October 2021

Context.The mutual orbital alignment in multiple planetary systems is an important parameter for understanding their formation. There are a number of elaborate techniques to determine the alignment parameters using photometric or spectroscopic data. Planet–planet occultations (PPOs), which can occur in multiple transiting systems, are one intuitive example. While the presence of PPOs constrains the orbital alignment, the absence at first glance does not.Aims.Planetary systems, for which the measurement of orbital obliquities with conventional techniques remains elusive, call for new methods whereby at least some information on the alignments can be obtained. Here we develop a method that uses photometric data to gain this kind of information from multi-transit events.Methods.In our approach we synthesize multi-transit light curves of the exoplanets in question via the construction of a grid of projected orbital tilt anglesα, while keeping all transit parameters constant. These model light curves contain PPOs for some values ofα. To compute the model light curves, we use the 3D animation software Blender for our transit simulations, which allows the use of arbitrary surface brightness distributions of the star, such as limb darkening from model atmospheres. The resulting model light curves are then compared to actual measurements.Results.We present a detailed study of the multi-transiting planetary system Kepler-20, including parameter fits of the transiting planets and an analysis of the stellar activity. We apply our method to Kepler-20 b and c, where we are able to exclude some orbital geometries, and find a tendency of these planets to eclipse in front of different stellar hemispheres in a prograde direction.Conclusions.Despite the low statistical significance of our results in the case of Kepler-20, we argue that our method is valuable for systems where PPO signals larger than the noise can occur. According to our analysis, noise ≤ 2 × 10−4for planets like Kepler-20 b, or a planet radius ≥ 3REarthfor the smaller component and Kepler-20-like photometry, would be sufficient to achieve significant results.