bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions to promote family member involvement in adult critical care settings: a systematic review
Authors: Xyrichis Andreas , Fletcher Simon , Philippou Julia , Brearley Sally , Terblanche Marius , Rafferty Anne Marie 
Published: April 2021

ObjectiveTo identify, appraise and synthesise evidence of interventions designed to promote family member involvement in adult critical care units; and to develop a working typology of interventions for use by health professionals and family members.DesignMixed-method systematic review.Data sourcesBibliographic databases were searched without date restriction up to June 2019: MEDLINE, EMBASE and CINAHL; the Cochrane Central Register of Controlled Trials, Joanna Briggs and Cochrane Libraries. Back issues of leading critical care and patient experience journals were manually searched, as were the reference lists of included studies. All evaluation studies of relevant intervention activities were included; all research designs and outcome measures were eligible. Due to heterogeneity in interventions, designs and outcome measures, the synthesis followed a narrative approach. Service users met with the research team termly.ResultsOut of 4962 possible citations, a total of 20 studies were included. The overall evidence base was assessed as moderate to weak. Six categories of interventions were identified: environmental unit changes (n=2), web-based support (n=4), discussion-based support (n=6), multicomponent support (n=4), participation in rounds (n=3) and participation in physical care (n=1). Clinical and methodological heterogeneity across studies hindered meta-analysis, hence a narrative synthesis was pursued. Six main outcomes were identified, grouped under two categories: (i) involvement outcomes: communication (mean differenceranged from 6.39 to 8.83), decision-making (mean differenceranged from −0.8 to 5.85), satisfaction (mean differenceranged from 0.15 to 2.48); and (ii) health outcomes: family trauma (mean differenceranged from −7.12 to 0.9), family well-being (mean differenceranged from −0.7 to −4), patient outcomes (relative riskranged from 1.27 to 4.91). The findings from the qualitative studies were thematically analysed to identify features of the interventions that participants perceived to influence effectiveness. Synthesised into five overarching categories (practicality, development, interaction, reflexivity and bridging), these can serve as principles to inform the future design and development of more refined family member involvement interventions.ConclusionsFuture interventions should be developed with much closer family member input and designed by considering the key features we identified. We call for future interventions to be multilayered and allow for a greater or lesser level, and different kinds, of involvement for family members. Choice of intervention should be informed by a baseline diagnostic of family members’ needs, readiness and preparedness for involvement.PROSPERO registrationCRD42018086325.
Virtual reality-based relaxation for enhancement of perioperative well-being and quality of life: protocol for a randomised pilot trial
Authors: Schrempf Matthias Christian , Petzold Julian Quirin , Vachon Hugo , Petersen Morten Aagaard , Gutschon Johanna , Wolf Sebastian , Sommer Florian , Murnauer Marcus , Anthuber Matthias 
Published: April 2021

IntroductionPatients with cancer undergoing surgery often suffer from reduced quality of life and various forms of distress. Untreated distress can negatively affect coping resources as well as surgical and oncological outcomes. A virtual reality-based stress reduction intervention may increase quality of life and well-being and reduce distress in the perioperative phase for patients with cancer. This pilot trial aims to explore the feasibility of the proposed intervention, assess patient acceptability and obtain estimates of effect to provide data for sample size calculations.Methods and analysisPatients with colorectal cancer and liver metastasis undergoing elective surgery will be recruited for this single-centre, randomised pilot trial with a three-arm design. A total of 54 participants will be randomised at 1:1:1 ratio to one of two intervention groups or a control receiving standard treatment. Those randomised to an intervention group will either receive perioperative virtual reality-based stress reduction exercises twice daily or listen to classical music twice daily. Primary feasibility outcomes are number and proportions of participants recruited, screened, consented and randomised. Furthermore, adherence to the intervention, compliance with the completion of the quality of life questionnaires and feasibility of implementing the trial procedures will be assessed. Secondary clinical outcomes are measurements of the effectiveness of the interventions to inform sample size calculations.Ethics and disseminationThe study protocol, the patient information and the informed consent form have been approved by the ethics committee of the Ludwigs-Maximilians-University, Munich, Germany (Reference Number: 19–915). Study findings will be submitted for publication in peer-reviewed journals.Trial registration numberDRKS00020909.
Trends in long-term opioid prescriptions for musculoskeletal conditions in Australian general practice: a national longitudinal study using MedicineInsight, 2012–2018
Authors: Black-Tiong Sean , Gonzalez-Chica David , Stocks Nigel 
Published: April 2021

ObjectiveDescribe trends and patterns in long-term opioid prescriptions among adults with musculoskeletal conditions (MSK).DesignInterrupted time-series analysis based on an open cohort study.SettingA representative sample of 402 Australian general practices contributing data to the MedicineInsight database.Participants811 174 patients aged 18+ years with an MSK diagnosis and three or more consultations in any two consecutive years between 2012 and 2018. Males represented 44.5% of the sample, 28.4% were 65+ years and 1.9% were Aboriginal or Torres Strait Islanders.Primary and secondary outcome measuresAnnual prevalence and cumulative incidence (%) of long-term opioid prescribing (3+ prescriptions in 90 days) among patients with an MSK. Average duration of these episodes in each year between 2012 and 2018.ResultsThe prevalence of long-term opioid prescribing increased from 5.5% (95% CI 5.2 to 5.8) in 2012 to 9.1% (95% CI 8.8 to 9.7) in 2018 (annual change OR 1.09, 95% CI 1.08 to 1.09), but a slightly lower incidence was observed in 2018 (3.0% vs 3.6%–3.8% in other years; annual change OR 0.99, 95% CI 0.98 to 0.99). The incidence was between 37% and 52% higher among practices located in rural Australia or lower socioeconomic areas. Individual risk factors included increasing age (3.4 times higher among those aged 80+ years than the 18–34 years group in 2012, increasing to 4.8 times higher in 2018), identifying as Aboriginal or Torres Strait Islander (1.7–1.9 higher incidence than their peers), or living in disadvantaged areas (36%–57% more likely than among those living in wealthiest areas). Long-term opioid prescriptions lasted in average 287–301 days between 2012 and 2016, reducing to 229 days in 2017 and 140 days in 2018. A longer duration was observed in practices from more disadvantaged areas and females in all years, except in 2018.ConclusionsThe continued rise in the prevalence of long-term opioid prescribing is of concern, despite a recent reduction in the incidence and duration of opioid management.
Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
Authors: Banchereau Romain , Chitre Avantika S. , Scherl Alexis , Wu Thomas D. , Patil Namrata S. , de Almeida Patricia , Kadel, III Edward E. , Madireddi Shravan , Au-Yeung Amelia , Takahashi Chikara , Chen Ying-Jiun , Modrusan Zora , McBride Jacqueline , Nersesian Rhea , El-Gabry Ehab A. , Robida Mark D. , Hung Jeffrey C. , Kowanetz Marcin , Zou Wei , McCleland Mark , Caplazi Patrick , Eshgi Shadi Toghi , Koeppen Hartmut , Hegde Priti S. , Mellman Ira , Mathews W. Rodney , Powles Thomas , Mariathasan Sanjeev , Grogan Jane , O'Gorman William E 
Published: April 2021

BackgroundCD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.MethodsHere, we test this by combining high-dimensional single-cell modalities with bulk tumor transcriptomics from 1868 patients enrolled in lung and bladder cancer clinical trials of atezolizumab (anti-programmed cell death ligand 1 (PD-L1)).ResultsITGAE was identified as the most significantly upregulated gene in inflamed tumors. Tumor CD103+ CD8+ TRM cells exhibited a complex phenotype defined by the expression of checkpoint regulators, cytotoxic proteins, and increased clonal expansion.ConclusionsOur analyses indeed demonstrate that the presence of CD103+ CD8+ TRM cells, quantified by tracking intratumoral CD103 expression, can predict treatment outcome, suggesting that patients who respond to PD-1/PD-L1 blockade are those who exhibit an ongoing antitumor T-cell response.
Cumulative burden of lipid profiles predict future incidence of ischaemic stroke and residual risk
Authors: Dai Liye , Xu Jie , Zhang Yijun , Wang Anxin , Chen Zimo , Mo Jinglin , Li Hao , Meng Xia , Wu Shouling , Wang Yongjun 
Published: April 2021

ObjectivesIncident ischaemic stroke (IS) risk may increase not only with lipids concentration but also with longer duration of exposure. This study aimed to investigate the impact of cumulative burden of lipid profiles on risk of incident IS.MethodsA total of 43 836 participants were enrolled who participated in four surveys during 2006–2013. Individual cumulative lipid burden was calculated as number of years (2006–2013) multiplied by the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-HDL-C and triglyceride (TG), respectively. The primary outcome was defined as the incident IS during 2012–2017.ResultsDuring 4.67 years (±0.70 years) follow-up on average, we identified 1023 (2.33%) incident IS. Compared with respective reference groups, the HRs (95% CIs) of the upper tertile in cumulative TG burden, cumulative LDL-C burden, cumulative TC burden and cumulative non-HDL-C burden were 1.26 mmol/L (1.02–1.55 mmol/L), 1.47 mmol/L (1.25–1.73 mmol/L), 1.33 mmol/L (1.12–1.57 mmol/L) and 1.51 mmol/L (1.28–1.80 mmol/L) for incidence of IS, respectively. However, this association was not significant in cumulative HDL-C burden and IS (HR: 1.09; 95% CI: 0.79 to 1.52), after adjustment for confounding variables. Among 16 600 participants with low cumulative LDL-C burden, HRs (95% CI) for TC, TG, non-HDL-C and HDL-C with IS were 1.63 mmol/L (1.03–2.57 mmol/L), 1.65 mmol/L (1.19–2.31 mmol/L), 1.57 mmol/L (1.06–2.32 mmol/L) and 0.98 mmol/L (0.56–1.72 mmol/L), respectively.ConclusionsWe observed the correlation between cumulative burden of lipid profiles, except for cumulative burden of HDL-C, with the risk of incident IS. Cumulative burden of TC, TG and non-HDL-C may still predict IS in patients with low cumulative LDL-C burden.Trial registration numberChiCTR-TNRC-11001489.
Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well: results from the MR CLEAN Registry
Authors: Dekker Luuk , Venema Esmee , Pirson F Anne V , Majoie Charles B L M , Emmer Bart J , Jansen Ivo G H , Mulder Maxim J H L , Lemmens Robin , Goldhoorn Robert-Jan B , Wermer Marieke J H , Boiten Jelis , Lycklama à Nijeholt Geert J , Roos Yvo B W E M , van Es Adriaan C G M , Lingsma Hester F , Dippel Diederik W J , van Zwam Wim H , van Oostenbrugge Robert J , van den Wijngaard Ido R 
Published: April 2021

BackgroundRandomised controlled trials with perfusion selection have shown benefit of endovascular treatment (EVT) for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well. However, outcomes after EVT in these late window patients without perfusion imaging are largely unknown. We assessed their characteristics and outcomes in routine clinical practice.MethodsThe Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry, a prospective, multicentre study in the Netherlands, included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017. CT perfusion was no standard imaging modality. We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age, prestroke modified Rankin Scale (mRS), National Institutes of Health Stroke Scale, Alberta Stroke Programme Early CT Score (ASPECTS), collateral status, location of occlusion and treatment with intravenous thrombolysis. Outcomes included 3-month mRS score, functional independence (defined as mRS 0–2), and death.ResultsOf 3264 patients who underwent EVT, 106 (3.2%) were treated beyond 6.5 hours (median 8.5, IQR 6.9–10.6), of whom 93 (87.7%) had unknown time of stroke onset. CT perfusion was not performed in 87/106 (80.2%) late window patients. Late window patients were younger (mean 67 vs 70 years, p<0.04) and had slightly lower ASPECTS (median 8 vs 9, p<0.01), but better collateral status (collateral score 2–3: 68.3% vs 57.7%, p=0.03). No differences were observed in proportions of functional independence (43.3% vs 40.5%, p=0.57) or death (24.0% vs 28.9%, p=0.28). After matching, outcomes remained similar (adjusted common OR for 1 point improvement in mRS 1.04, 95% CI 0.56 to 1.93).ConclusionsWithout the use of CT perfusion selection criteria, EVT in the 6.5–24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics. randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window.
Characteristics of self-inflicted injury among suicidal patients: analysis of nation-wide trauma registry
Authors: Nishimura Takeshi , Naito Hiromichi , Nakao Atsunori , Nakayama Shinichi 
Published: April 2021

PurposeSelf-inflicted injury is one of the most common causes of suicide. Extremity injury is thought to occur most frequently among penetrating injury; however, epidemiology among patients attempting suicide is unknown. This study aims to find the characteristics of penetrating self-inflicted trauma patients.MethodsThis is a retrospective cohort study of Japanese nation-wide trauma registry (the Japan National Trauma Data Bank) between January 1, 2004 and December 31, 2017. Patients who attempted suicide with penetrating injury were eligible. We evaluated the occurrence of injury based on injury site (neck/face, chest, abdomen, extremity) as a dependent variable and aging as an independent variable using a generalized linear model and compare those groups with spline models.Results4576 trauma patients were eligible. Excluding patients with missing age, missing survival data, and missing abbreviate injury score, 4183 patients were enrolled in this study. Common injury site is follows: abdomen 1772 patients (42.4%), extremity 1344 patients (32.0%), neck/face 1253 patients (30.0%), and chest 993 patients (23.7%). The occurrence of neck/face injury, chest injury, and abdominal injury increased with age. On contrary, the rate of extremity injury decreased with age.ConclusionsAmong self-inflicted trauma patients, abdominal injury was the most common injury, and neck/face injury, chest injury, and abdominal injury were related with aging. On the contrary, the rate of extremity injury decreased as patients’ age progressed.Level of evidenceRetrospective cohort study, Level III.
Analytical representation for amplitudes and differential cross section of pp elastic scattering at 13 TeV
Authors: Ferreira E. , Kohara A.K. , Kodama T. 
Published: April 2021

AbstractWith analytical representation for the pp scattering amplitudes introduced and tested at lower energies, a description of high precision is given of the$$d\sigma /dt$$dσ/dtdata at$$\sqrt{s}= 13$$s=13 TeV for all values of the momentum transfer, with explicit identification of the real and imaginary parts. In bothtandbcoordinates the amplitudes have terms identified as of non-perturbative and perturbative nature, with distinction of their influences in forward and large |t| ranges and in central and peripheral regions respectively. In the forward range, the role of the Coulomb-nuclear interference phase is investigated. The energy dependence of the parameters of the amplitudes are reviewed and updated, revealing a possible emergence of a peculiar behavior of elastic and inelastic profiles in b-space for central collisions, which seems to be enhanced quickly at higher energies. Some other models are also briefly discussed in comparison, including the above mentioned behavior in b-space.
Supervised learning-based reconstruction of magnet errors in circular accelerators
Authors: Fol E. , Tomás R. , Franchetti G. 
Published: April 2021

AbstractMagnetic field errors and misalignments cause optics perturbations, which can lead to machine safety issues and performance degradation. The correlation between magnetic errors and deviations of the measured optics functions from design can be used in order to build supervised learning models able to predict magnetic errors directly from a selection of measured optics observables. Extending the knowledge of errors in individual magnets offers potential improvements of beam control by including this information into optics models and corrections computation. Besides, we also present a technique for denoising and reconstruction of measurements data, based on autoencoder neural networks and linear regression. We investigate the usefulness of supervised machine learning algorithms for beam optics studies in a circular accelerator such as the LHC, for which the presented method has been applied in simulated environment, as well as on experimental data.
Women, Land Tenure Dynamics and Land Sales in Rural Areas. The Case of Syukula Village, Tanzania
Authors: Mwaipopo Rosemarie N. 
Published: April 2021

Abstract
Women’s engagement in rural land sales has been a significant aspect of land tenure dynamics with varied implications to their livelihoods and wellbeing. However, the factors that influence women’s decisions and the modalities of such engagement have not received much attention in social analysis, specifically with regard to women’s perceptions, responses and actions towards land sales, especially in situations of land shortage. In the context where multiple and interacting factors are continuing to transform rural land tenure patterns, this article discusses the varied implications of recent land sales to women, with possible extension of their vulnerabilities, yet also re-invigorating women’s agency regarding land ownership rights. Using a feminist political-ecological perspective, this article shows how women act under constraining circumstances to transform gender relations and patterns of land ownership with varying outcomes to their wellbeing. The findings also suggest deeper interrogation on the capacities of grassroots structures obligated to oversee land tenure security for communities and upholding women’s rights of access to land.
Rethinking Social Action through Music
Authors: Baker Geoffrey 
Published: April 2021

How can we better understand the past, present and future of Social Action through Music (SATM)?
This ground-breaking book examines the development of the Red de Escuelas de Música de Medellín (the Network of Music Schools of Medellín), a network of 27 schools founded in Colombia’s second city in 1996 as a response to its reputation as the most dangerous city on Earth. Inspired by El Sistema, the foundational Venezuelan music education program, the Red is nonetheless markedly different: its history is one of multiple reinventions and a continual search to improve its educational offering and better realise its social goals. Its internal reflections and attempts at transformation shed valuable light on the past, present, and future of SATM.
Time-Varying Empirical Probability Densities of Southern Ocean Surface Winds: Linking the Leading Mode to SAM and QuantifyingWind Product Differences
Authors: Hell Momme C. , Cornuelle Bruce D. , Gille Sarah T. , Lutsko Nicholas J. 
Published: April 2021

AbstractSouthern Ocean (SO) surface winds are essential for ventilating the upper ocean by bringing heat and CO2 to the ocean interior. The relationships between mixed-layer ventilation, the Southern Annular Mode (SAM), and the storm tracks remain unclear because processes can be governed by short-term wind events as well as long-term means.In this study, observed time-varying 5-day probability density functions (PDFs) of ERA5 surface winds and stresses over the SO are used in a singular value decomposition to derive a linearly independent set of empirical basis functions. The first modes of wind (72% of the total wind variance) and stress (74% of the total stress variance) are highly correlated with a standard SAM index (r = 0.82) and reflect SAM’s role in driving cyclone intensity and, in turn, extreme westerly winds. This Joint PDFs of zonal and meridional wind show that southerly and less westerly winds associated with strong mixed-layer ventilation are more frequent during short and distinct negative SAM phases. The probability of these short-term events might be related to mid-latitude atmospheric circulation. The second mode describes seasonal changes in the wind variance (16% of the total variance) that are uncorrelated with the first mode.The analysis produces similar results when repeated using 5-day PDFs from a suite of scatterometer products. Differences between wind product PDFs resemble the first mode of the PDFs. Together, these results show a strong correlation between surface stress PDFs and the leading modes of atmospheric variability, suggesting that empirical modes can serve as a novel pathway for understanding differences and variability of surface stress PDFs.
Leptospira infection in people in the city of Durango, Mexico: a cross sectional study
Authors: Sandoval-Carrillo Ada Agustina , Salas-Pacheco José Manuel , Antuna-Salcido Elizabeth Irasema , Castro-Martínez Karla Sujey , Ortiz-Montaño Diana Stephanie , Beristain-Garcia Isabel , Alvarado-Retana Hilda Mariela , Ramos-Nevarez Agar , Salas-Pacheco Sergio Manuel , Sifuentes-Alvarez Antonio , Rábago-Sánchez Elizabeth , Cerrillo-Soto Sandra Margarita , Castellanos-Juárez Francisco Xavier , Contreras-Cisneros Edith , Alvarado-Esquivel Cosme 
Published: April 2021

Objective To determine the seroprevalence of Leptospira immunoglobulin (Ig)G and IgM antibodies and its association with the characteristics of the study population from the northern Mexican city of Durango, Mexico. Methods Through a cross-sectional study design, inhabitants of Durango City, Mexico were surveyed between June 2018 and November 2018. Serum samples from the subjects were analysed for anti- Leptospira IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays. Sociodemographic, clinical, behavioural and housing characteristics were recorded. Data were analysed by bivariate and multivariate analyses. Results The study enrolled 413 people, of which 124 (30.0%) and 137 (33.2%) were positive for anti- Leptospira IgG antibodies and anti- Leptospira IgM antibodies, respectively. Multivariate analysis showed that Leptospira seropositivity was associated with professional occupation, alcohol consumption, ill clinical status, memory impairment and a history of surgery. Conclusions This is the first study to report the seroepidemiology of Leptospira infection in an urban general population in the north of Mexico. The seroprevalence of Leptospira infection found was higher than those previously reported in Mexican studies.