bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics Analysis of Gene Expression Profiles of Immune-mediated Necrotizing Myopathy
Authors: Shi Jiaying , Wang Shule , Zhang Jingfei , Chang Xueli , Wang Juan , Zhang Jing , Guo Junhong , Zhang Wei 
Published: January 2021

Abstract
Background: Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy with limited therapeutic measures. This study aims to elucidate the potential biomarkers and investigate the underlying mechanisms in IMNM. Materials and Methods: Microarray datasets in GSE128470 and GSE39454 were obtained from the Gene Expression Omnibus. Differentially expressed genes (DEGs) were filtrated by limma package in R statistical software. Functional enrichment analyses were performed using DAVID online tools. STRING database was used to construct protein‑protein interaction (PPI) networks. The module analysis and hub genes validation were performed using Cytoscape software. Results: Integrated analysis of two databases revealed 160 co-expressed DEGs in IMNM, including 80 downregulated genes and 80 upregulated genes. GO enrichment analysis revealed that sarcomere is the most significantly enriched GO term within the DEGs. KEGG pathway enrichment analysis revealed significant enrichment pathways in cancer. A PPI network consisting of 115 nodes and 205 edges were constructed and top 20 hub genes were identified. Two key modules from the network were identified. Eight hub genes in module 1 (MYH3, MYH7B, MYH8, MYL5, MYBPH, ACTC1, YNNT 2 and MYOG) are tightly associated with skeletal muscle construction. Seven hub genes in module 2 (C1QA, TYROBP, MS4A6A, RNASE6, FCGR2A, FCER1G and LAPTM5) mainly take part in immune response. Conclusions: Our research indicated that cancer-related pathways, skeletal muscle construction pathways and immune-mediated pathways might participate in the development of IMNM. Identified hub genes may serve as potential biomarkers or targets for early diagnosis.
A Biomimetic Peptide has no Effect on the Isotopic Fractionation during in Vitro Silica Precipitation
Authors: Cassarino Lucie , Curnow Paul , Hendry Katharine 
Published: January 2021

Abstract
The stable isotopic composition of diatom silica is used as a proxy for nutrient utilisation in natural waters. This approach provides essential insight into the current and historic links between biological production, carbon cycling and climate. However, estimates of isotopic fractionation during diatom silica production from both laboratory and field studies are variable, and the biochemical pathways responsible remain unknown. Here, we investigate silicon isotopic fractionation through a series of chemical precipitation experiments that are analogous to the first stages of intracellular silica formation within the diatom silicon deposition vesicle. The novelty of our experiment is the inclusion of the R5 peptide, which is closely related to a natural biomolecule known to play a role in diatom silicification. Our results suggest that the presence of R5 induces a systematic but non-significant difference in fractionation behaviour. It thus appears that silicon isotopic fractionation in vitro is largely driven by an early kinetic fractionation during rapid precipitation that correlates with the initial amount of dissolved silica in the system. Our findings raise the question of how environmental changes might impact silicon isotopic fractionation in diatoms, and whether frustule archives record information in addition to silica consumption in surface water.
3D Numerical Simulation of Acoustophoretic Motioninduced by Boundary-driven Acoustic Streaming Instanding Surface Acoustic wave Microfluidics
Authors: Namnabat MS , Zand Mahdi Moghimi , Houshfar E 
Published: January 2021

Abstract
Standing surface acoustic waves (SSAWs) have been widely utilized in microfluidic devices to manipulate various cells and micro/nano-objects. Despite widespread application, a time-/cost-efficient versatile 3D model that predicts the particle behavior in such platforms is still lacking. Herein, a fully-coupled 3D numerical simulation of boundary-driven acoustic streaming in the acoustofluidic devices utilizing SSAWs has been conducted based on the limiting velocity finite element method. Through this efficient computational method, the underlying physical interplay from the electromechanical fields of the piezoelectric substrate to different acoustofluidic effects (acoustic radiation force and streaming-induced drag force), fluid-solid interactions, the 3D influence of novel on-chip configuration like tilted-angle SSAW (taSSAW) based devices, required boundary conditions, meshing technique, and demanding computational cost, are discussed. As an experimental validation, a taSSAW platform fabricated on YX 128 LiNbO3 substrate for separating polystyrene beads is simulated, which demonstrates acceptable agreement with reported experimental observations. Subsequently, as an application of the presented 3D model, a novel sheathless taSSAW cell/particle separator is conceptualized and designed. The presented 3D fully-coupled model, due to the more time-/cost-efficient performance than precedented 3D models, the capability to model complex on-chip configurations, and overcome shortcomings and limitations of 2D simulations could be considered as a powerful tool in further the designing and optimizing SSAW microfluidics.
Meta-Consent for the Secondary Use of Health Data Within A Learning Health System: A Qualitative Study of the Public’s Perspective.
Authors: Cumyn Annabelle , Barton Adrien , Dault Roxanne , Safa Nissrine , Cloutier Anne-Marie , Ethier Jean-François 
Published: January 2021

Abstract
Background: The advent of learning healthcare systems (LHSs) raises an important implementation challenge concerning how to request and manage consent to support secondary use of data in learning cycles, particularly research activities. Current consent models in Quebec were not established with the context of LHSs in mind and do not support the agility and transparency required to obtain consent from all involved, especially the citizens. Therefore, a new approach to consent is needed. Previous work identified the meta-consent model as a promising alternative to fulfill the requirements of LHSs, particularly large-scale deployments. We elicited the public’s attitude toward the meta-consent model to evaluate if the model could be understood by the citizens and would be deemed acceptable to prepare for its possible implementation in Quebec. Methods: Eight focus groups, with a total of 63 members of the general public from various backgrounds were conducted in Quebec, Canada, in 2019. Explicit attention was given to literacy levels, language spoken at home and rural vs urban settings. We assessed attitudes, concerns and facilitators regarding key components of the meta-consent model: predefined categories to personalized consent requests, a dynamic web-based infrastructure to record meta-consent, and default settings. To analyse the discussions, a thematic content analysis was performed using a qualitative software. Results: Our findings showed that participants were supportive of this new approach of consent as it promotes transparency and offers autonomy for the management of their health data. Key facilitators were identified to be considered in the implementation of a meta-consent model in the Quebec LHSs: information and transparency, awareness campaigns, development of educational tools, collaboration of front-line healthcare professionals, default settings deemed acceptable by the society as well as close partnerships with recognized and trusted institutions.Conclusions: This qualitative study reveals the openness of a sample of the Quebec population regarding the meta-consent model for secondary use of health data for research. This first exploratory study conducted with the public is an important step in guiding decision-makers in the next phases of implementing the various strategies to support access and use of health data in Quebec.
Diffusion anisotropy descriptor revealing morphology effect of H-ZSM-5 zeolite for olefin catalytic cracking
Authors: Liu Xiaoliang , Shi Jing , Yang Guang , Zhou Jian , Wang Chuanming , Teng Jiawei , Wang Yangdong , Xie Zaiku 
Published: January 2021

Abstract
Zeolite morphology is vital in determining catalytic activity, selectivity and stability in zeolite catalysis, while quantitative description of morphology effect is great challenging but highly desirable. Herein, a descriptor to elucidate the morphology effect is proposed by revealing the diffusion anisotropy in straight and sinusoidal channels of H-ZSM-5 zeolite for olefin catalytic cracking. A series of H-ZSM-5 zeolites with similar nano-sheet morphology were precisely synthesized in which only the length in c-axis varies. It is unexpectedly demonstrated that the catalytic activity and stability can be obviously improved by employing samples with longer length in c-axis. Combining time-resolved in-situ FT-IR spectroscopy with molecular dynamic simulations, we revealed that the difference in catalytic performance can be attributed to the intracrystalline diffusive propensity in different channels. This work not only provides a clear descriptor revealing morphology effect, but also offers deep insight into design of highly effective zeolite catalysts for olefin catalytic cracking.
Platelet-Rich Plasma versus Corticosteroid Injections in Rotator Cuff Related Shoulder Pain: A Comparative Study with Up to 18 Months of Follow-Up
Authors: Annaniemi Juho , Pere Jüri , Giordano Salvatore 
Published: January 2021

Abstract
Purpose: Given the complications involved in corticosteroid (CS) injections, subacromial platelet-rich plasma (PRP) injections may provide a valid alternative to CS in the treatment of rotator cuff related shoulder pain (RCRSP).Methods: We retrospectively reviewed a total of 98 patients affected by RCRSP who were treated with either subacromial injection of PRP or CS. The PRP group received three injections of autologous PRP at two weeks interval, and the CS group received one injection of CS. Western Ontario Rotator Cuff Index (WORC) was the primary outcome measure, while secondary outcome measures were the Visual Analogue Scale (VAS), Range of Motion (ROM) and need for cuff repair surgery, which were analyzed at interval of 6, 12, and 18 months.Results: A total of 75 patients were included in the analysis (PRP n = 35, CS n = 40). Mean follow-up was (PRP 21.1 ± 8.7 months vs CS 33.6 ± 16.3 months, p <0.001). Both groups showed improvement in WORC, VAS and ROM. No significant differences were detected between the two groups in any of the primary (WORC) or secondary outcomes during 6, 12 and 18 months (all p > 0.05). No adverse events were detected.Conclusion: Both treatments improve RCRSP patient’s symptoms, but none of them seems to result in a significant better outcome in this series of patients. PRP can be a safe and feasible alternative to CS in treatment of RCRSP even at long follow-up, to reduce local and systemic effects involved with CS injections.
Implantable Brain-Computer Interface for Volitional Hand Grasp in Spinal Cord Injury
Authors: Jagid Jonathan , Cajigas Iahn , Davis Kevin , Meschede-Krasa Benyamin , Prins Noeline , Gallo Sebastian , Naeem Jasim , Palermo Anne , Wilson Audrey , Guerra Santiago , Parks Brandon , Zimmerman Lauren , Gant Katie , Levi Allan , Dietrich W. Dalton , Fisher Letitia , Vanno Steven , Tauber John , Garwood Indie , Abel John , Brown Emery , Ivan Michael , Prasad Abhishek 
Published: January 2021

Abstract
Loss of hand function after cervical spinal cord injury severely impairs functional independence. We describe a method for restoring volitional control of hand grasp in a subject with complete cervical quadriplegia (C5 ASIA Impairment Scale A) using a portable fully implanted brain-computer interface (BCI) within the home environment. The BCI consists of subdural surface electrodes placed over the dominant-hand motor cortex and connects to a transmitter implanted subcutaneously below the clavicle, which allows continuous reading of the electrocorticographic (ECoG) activity. Movement-intent was used to trigger functional electrical stimulation (FES) of the dominant hand during an initial 29-week laboratory study and subsequently via a mechanical hand orthosis during in-home use. Movement intent information could be decoded consistently throughout the 29-week in-laboratory study with a mean accuracy of 89.0% (range 78-93.3%). Improvements were observed in both the speed and accuracy of various upper extremity tasks, including lifting small objects and transferring objects to specific targets. After study week 23, the subject began to be able to extend his right thumb volitionally in the absence of the FES orthosis. At home decoding accuracy during open-loop trials reached an accuracy of 91.3% (range 80-98.95%) and an accuracy of 88.3% (range 77.6-95.5%) during closed-loop trials. A fully implanted BCI can be safely used to reliably decode movement intent from motor cortex, allowing for accurate volitional control of hand grasp and may potentially re-engage latent neural pathways to allow targeted re-innervation of muscles below the level of injury. (Funded by the Miami Project to Cure Paralysis; ClinicalTrials.gov number, NCT02564419.)
Association Between Gestational Bell’s Palsy and Preeclampsia and Other Pregnancy-Related Metabolic Disorders: A Retrospective Comparative Case Study
Authors: Leelawai Sumonthip , Suwanrath Chitkasaem , Pruphetkaew Nannapat , Chongphattararot Pensri , Sathirapanya Pornchai 
Published: January 2021

Abstract
BackgroundThe associations between gestational Bell’s palsy (GBP) and preeclampsia (PE) and other pregnancy-related metabolic disorders such as gestational hypertension (GHT) and gestational diabetes mellitus (GDM) remain unclear. We aimed to evaluate these associations and to compare the neonatal outcomes between the newborns of pregnant women with and without GBP.MethodsThis was a retrospective 1:5 comparative case study between pregnant women with and without GBP. GBP cases in Songklanagarind Hospital from 2006 to 2016 were enrolled. The exact maternal age and order of gravidity at the onset of GBP were matched. The associations between GBP and PE, GHT and GDM were evaluated comparatively. Also, the outcomes of newborns from the two pregnant women groups were compared and analyzed by univariable analysis (p<0.05).ResultsEight GBP cases out of 8,756 pregnant women were enrolled. Six of the GBP cases were first or second gravidity pregnancies. Five cases developed GBP during the third trimester. Except for significantly higher median systolic and diastolic blood pressures (SBP and DBP) in the GBP cases, we found no significant associations between GBP and PE, GHT or GDM. Additionally, the neonates of the GBP women had significantly lower mean birth weight.ConclusionsWe found that GBP had no associations with PE, GHT or GDM. However, significantly lower birth weight was found in the newborns of the GBP women. The higher median SBP and DBP found in the GBP women may imply that a common pathogenesis of microvasculopathy between GBP and late pregnancy-related complications exists.
The Meaning of Serum CRP, ESR, Platelet Count and Mean Platelet Volume ratio(PC/MPV) and plasma Fibrinogen in the Diagnosis of Periprosthetic Joint Infection
Authors: Huang Jincheng , Zhang Jingyi , Gao Zongyan , Chen Xiao , Dai Zhipeng , Dong Yonghui , Zheng Wendi , Liu Jijun , Zheng Jia , Jin Yi 
Published: January 2021

Abstract
BackgroundThe purpose of this study was to test the meaning of serum CRP, ESR, Platelet Count and Mean Platelet Volume ratio (PC/MPV) and plasma Fibrinogen in periprosthetic joint infection diagnosis. MethodsClinical data of 160 patients diagnosed with osteoarthritis (Group A), PJI (Group B) and aseptic loosening after joint arthroplasy (Group C) were retrospective studied. General data and preoperative serum CRP, ESR, Platelet count to Mean Platelet Volume ratio and plasma Fibrinogen level were recorded and compared.ResultsSerum CRP, ESR, PC/MPV and plasma Fibrinogen expression level in Group B are much higher than Group A and C. When PC/MPV>31.70 was set as the optimum threshold value for the diagnosis of PJI, the specificity of PC/MPV in PJI diagnosis was lower than CRP and ESR, whereas, the sensitivity of PC/MPV in PJI diagnosis was similar with CRP and ESR. When plasma Fibrinogen > 4.01 μg/mL was set as the optimum threshold value for the diagnosis of PJI, the specificity and sensitivity of plasma Fibrinogen in diagnosis of PJI was similar with CRP and ESR. ConclusionPC/MPV should not be used as the first screen marker for PJI diagnosis, whereas, the plasma Fibrinogen can be used as a new marker for PJI diagnosis.
Screening and understanding Li adsorption on 2-dimensional metallic materials by learning physics
Authors: Gong Sheng , Wang Shuo , Zhu Taishan , Chen Xi , Grossman Jeffrey 
Published: January 2021

Abstract
Two-dimensional (2D) materials have received considerable attention as possible electrodes in Li-ion batteries (LIBs), although a deeper understanding of the Li adsorption behavior as well as broad screening of the materials space is still needed. In this work, we build a high-throughput screening scheme that incorporates a learned interaction. First, density functional theory and graph convolution networks are utilized to calculate minimum Li adsorption energies for a small set of 2D metallic materials. The data is then used to find a dependence of the minimum Li adsorption energies on the sum of ionization potential, work function of the 2D metal, and coupling energy between Li+ and substrate. Our results show that variances of elemental properties and density are the most correlated features with coupling. To illustrate the applicability of this approach, the model is employed to show that some fluorides and chromium oxides are potential high-voltage materials with adsorption energies < -7 eV, and the found physics is used as the design principle to enhance the Li adsorption ability of graphene. This physics-driven approach shows higher accuracy and transferability compared with purely data-driven models.
Evaluating the impact of investing in the industry of clinical practice guidelines for health systems
Authors: Hassanien Amal 
Published: January 2021

Abstract
Rationale: This research has been conducted to facilitate evidence-informed policymaking and to help health-care policymakers in Saudi Arabia to decide whether or not a sustainable investment in the CPG industry is socially and economically viable. Objectives: The objective is to investigate: (i) whether the clinical practice guidelines help to improve clinical practice and save costs, and (ii) the views in Saudi Arabia about implementing clinical practice guidelines. Methods: The study employs mixed methods, including: (i) a literature review to evaluate the benefits of implementing clinical practice guidelines, and (ii) an online survey to investigate views about implementing the guidelines' benefits. Results: (i) The clinical practice guidelines do help in improving clinical practice, but the evidence about their impact on saving costs is insufficient in the literature. (ii) The survey demonstrated a high level of awareness among health system actors in Saudi Arabia of the importance of having nationally unified clinical guidelines. Recommendations: Investment in the clinical practice guidelines industry seems socially and economically viable.
An N-of-1 Trial of Itacitinib for a Patient with Aplastic Anemia Associated with a Gain-of-Function Variant in STAT1
Authors: Rosenberg Jacob , Hughes Travis , Peters Joshua , Lareau Caleb , Ludwig Leif , Massoth Lucas , Austin-Tse Christina , Rehm Heidi , Bryson Bryan , Fortune Sarah , Chen Yi-Bin , Shalek Alex , Sykes David 
Published: January 2021

Abstract
An 18-year-old man presented with aplastic anemia, and exome sequencing identified a germline gain-of-function variant in the gene STAT1. Treatment with itacitinib, an investigational selective Janus Kinase 1 (JAK1) inhibitor, resulted in prompt recovery of hematopoiesis. An exhausted CD8+ T cell population and myeloid populations enriched for an interferon-y signature correlated with disease activity. Patient bone marrow sections displayed increased phospho-STAT1 staining, as did other idiopathic aplastic anemia cases, suggesting a shared pathophysiologic mechanism. This study describes the success and mechanism of a molecularly targeted therapy with potential implications for the treatment of aplastic anemias and other autoimmune disorders.
Solubility of the Ketoconazole (an Antifungal Drug) in Supercritical Carbon Dioxide and Menthol as a Cosolvent (Ternary System): Experimental Data and Empirical Correlations
Authors: Sodeifian Gholamhossein , Sajadian Seyed Ali , Razmimanesh Fariba , Hazaveie Seyed Mojtaba 
Published: January 2021

Abstract
One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 1.70×10− 6 and 8.02×10− 4, while drug solubility in the SC-CO2 with cosolvent varied from 2.7×10− 5 to 1.96×10− 4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD,%= 6.45, Radj= 0.995.
Design and Fabrication of Soft X ray Suppermirrors
Authors: Wang Hanlin , Wang Haifeng , Ren Shuai , Zhou Peng , Zheng Xin , Chen Bo , Chen Zhongjun , Liu Shuhu , Wang Xiaodong 
Published: January 2021

Abstract
W/Si, Ir/SiC, and Pt/C supermirrors were designed by block method and fabricated by magnetron sputtering method. The glancing incident angles are 1.0, 1.4 and 1.7 degree. Pt/C supermirrors show better spectral results than W/Si, Ir/SiC. Pt/C supermirrors also have good angular tolerance, which will benefit opt-mechanic alignment. In addition, Pt layer as outmost one can withstand harsh space environment.