bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXPERIENCIAS EN SEGURIDAD Y SALUD LABORAL EN EL TRABAJO
Authors: ALVAREZ VÁZQUEZ INES 
Published: April 2021

En principio, cuando hablamos de teletrabajo, creemos que es una manera cómoda de hacer nuestra actividad laboral desde casa y, además, consideramos que es un buen instrumento para conciliar trabajo y vida personal; pero pocas veces, reflexionamos sobre si el teletrabajo puede generar riesgos laborales. La verdad es que el teletrabajo genera riesgos, sobre todo en el ámbito psicosocial.
En consecuencia, la implantación de esta modalidad de empleo en cualquier entidad pública o privada requiere una planificación preventiva previa por parte de quien contrate al teletrabajador o teletrabajadora. Esa planificación se ha de basar en una evaluación certera de los factores de riesgo laboral y en el diseño e implantación de las medidas preventivas oportunas.
Pero, además, el teletrabajo puede ser una herramienta eficaz para proteger a los y las empleadas especialmente sensibles de una empresa o de una administración ya que permite adaptar el puesto de trabajo a las especiales condiciones psicofísicas de ese personal.
Hasiera batean, telelanari buruz hitz egitean, lan-jarduerak etxetik eta erosotasunez burutzeko modua dela uste dugu, eta gainera, lana eta bizitza pertsonala bateragarri egiteko tresna egokitzat jotzen dugu. Hala ere, gutxitan aztertzen dugu telelanak laneko arriskuak sor ditzakeen edo ez. Egiatan, telelanak arriskuak sortzen ditu, batez ere eremu psikosozialean.
Ondorioz, lan-modalitate hori edozein erakunde publiko edo pribatuan ezartzeak aurretiazko prebentziozko plangintza eskatzen du telelangilea kontratatzen duenaren partetik. Plangintza horren oinarriak hurrengoak izan behar dira: laneko arriskuen faktoreen ebaluazio egokia eta dagokion prebentziozko neurriak diseinatzea eta ezartzea.
Bestalde, telelana bereziki tresna eraginkorra izan daiteke enpresa edo administrazio batean sentiberak diren langileak babesteko, lanpostua langile horien egoera psikofisikoetara egokitzeko aukera ematen baitu.
In principle, when we talk about teleworking, we believe that it is a comfortable way to do our work activity from home; in addition, we consider it to be a good instrument for achieving work-life balance; but we rarely ask ourselves whether teleworking can generate occupational risks. The truth is that teleworking generates risks, especially in the psychosocial area.
Consequently, the implementation of this type of employment in any public or private entity requires prior preventive planning by whoever hires the teleworker. This planning must be based on an accurate assessment of occupational risk factors and the design and implementation of appropriate preventive measures.
But teleworking can also be an effective tool to protect particularly sensitive employees of a company or an administration since it allows the workplace to be adapted to the special psychophysical conditions of those members of staff.
O sujeito Da Vinci e seu devir cientista
Authors: Xavier Cavalcante Ferreira Karine 
Published: April 2021

Leonardo da Vinci é evocado na literatura do pensamento científico pela originalidade e pluralidade de suas obras, seu legado nos dá notícias da relação inquieta entre o pesquisador e seus objetos de pesquisa. Representante das mentes mais brilhantes do Renascimento, Da Vinci conduz seus biógrafos e todos os interessados ao momento de transição do pensamento científico entre a baixa idade média e a idade moderna. Será através da perspectiva koyreriana desta transição ocidental que daremos destaque ao seu devir cientista, valorizando-o como sujeito da medida, do cálculo, da exatidão, e de sua inquietude, elementos que o expõe na vanguarda de uma nova linguagem no campo do saber.
De depressieve nasleep van bestuurlijke manie en verval bij corporatiebestuurders
Authors: Bokhorst Meike 
Published: April 2021

The depressive aftermath of managerial mania and decline by housing corporate executives
Incidents in the semi-public sector regularly reveal the underlying problems of managerial mania and decline. Since the Parliamentary Committee of Inquiry into Housing Associations and the new Housing Act, there have been fewer incidents involving managerial hubris and risky projects. However, in the event of incidents, the share of administrative decline of often long-serving directors of small corporations in particular is still considerable. The question in this article is what forms of managerial mania and decline occur among corporation directors and what internal and external supervisors can do to identify and mitigate this in a timely manner. To answer that question, this article examines the theory and practice of managerial mania and decline. Case analysis shows which manifestations of managerial mania and decline there were in the housing association sector. Internal and external supervisors can counter managerial mania and decline by exchanging knowledge with each other about the weak signals of decline and effective forms of countervailing power.
Information sources for patients undergoing corneal refractive surgery: results from a cross-sectional patient survey from a single private center in Poland
Authors: Przewłócka, BSc Katarzyna , Kanclerz Piotr 
Published: April 2021

PurposeTo identify the information sources for patients undergoing laser vision correction.MethodsIndividuals who underwent corneal refractive surgery at a private practice from December 2017 to August 2018 and agreed to complete an anonymous questionnaire were included. The manifest refraction and surgical method was recorded and correlated with the questionnaire results.ResultsData collected from 126 patients (mean age, 32.8 ± 8.6 years; 55.6% women) were analyzed. Of 121 patients, 120 (99.2%) identified the Internet as a source for information on refractive surgery, and 71 of 119 (59.7%) noted that the clinic’s website influenced their choice of clinic. Patients with high myopia more commonly used contact lenses and had considered undergoing refractive surgery for a longer time compared with patients with other refractive errors (P < 0.01 and P < 0.01, resp.). Patients with hyperopia were less likely to know their own refractive error (P = 0.02).ConclusionsIn this patient cohort, the Internet was the main source of information for those undergoing refractive surgery.
A POSSIBILIDADE DE APLICAÇÃO DA TESE DA PROTEÇÃO GRADUAL DA VIDA EM SEU FIM NO BRASIL
Authors: Lazarini Paula Xavier 
Published: April 2021

É indispensável o estudo de eutanásia e da possibilidade de proteção gradual da vida ao passo que, graças à medicina, a expectativa de vida está aumentando e, consequentemente, o número de idosos também. O atual ordenamento jurídico prevê a ilegalidade da eutanásia, entretanto, observa-se, na prática, a insatisfação de grupos de pessoas quanto ao tema, exigindo diálogo e novas compreensões, principalmente por estar havendo mudança na pirâmide etária brasileira. É de suma importância prezar e reivindicar os direitos de cada um de optar, com base em suas respectivas convicções, quais são seus desejos finais, principalmente ao enfrentar alguma doença ou estado em que não é capaz de decidir por si só quais são os limites e diretrizes dos seus cuidados. O presente estudo tem como objetivo avaliar se o Estado precisa, necessariamente, proteger a vida de forma tão intensa quando o seu fim está próximo. Também é abordado quais são os principais argumentos contra e a favor do instituto, bem como o posicionamento do atual ordenamento jurídico, para favorecer uma discussão atual. Por meio de “estudo de caso”, foi feito uma pesquisa das decisões proferidas a respeito do tema de aborto para entender os fundamentos utilizados na aplicação da graduação da vida. Após esse “estudo de caso”, foi avaliado se os argumentos poderiam ser também utilizados no tema eutanásia, e assim, atingir o objetivo principal do estudo, que é saber se é possível a aplicação de uma graduação da vida no final dela. Foi concluído que é cedo para decidir o marco em que se daria a diminuição da proteção à vida, contudo, já se observam indícios de que é possível, fazer a comparação entre a eutanásia e o aborto, pois trata-se, coincidentemente, de princípios comuns entre eles.
Palavras-chave: eutanásia, proteção gradual da vida, boa-morte.
Curving Performance of Straddle-Type Monorail Vehicle with Single-Axle Bogies Based on Spatial Multi-Body Dynamic Analysis
Authors: Zixue Du , Junchao Zhou , Zhen Yang , Zhouzhou Xu 
Published: April 2021

Straddle-type monorail ,as a unique technology, energy saving and environmental protection, is different from the subway of urban rail transit system. In order to study the curving performance of a new type of the straddle-type monorail vehicle with single-axle bogies ,the three-dimensional spatial dynamics model which consists of the vehicle model and track model designis proposed by the multi-body dynamics soft ADAMS. The monorail vehicle dynamic model which consists of three types of tire -track contact model and the nonlinear model of the horizontal stop is established. Based on the dynamic model, the influences such as pre pressure and curve super-high rate parameters of the curve passing for the dynamic characteristics are discussed. The simulation results show that the suitable preload for the guide and stabilizer tires of straddle-type vehicle with single-axle bogies is 5KN and after selecting the appropriate pre-pressure, the super-high rate is recommended to be 8%-10%.
Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells
Authors: Teo Michelle Yee Mun , Ng Jeremy Jeack Ceen , Fong Jung Yin , Hwang Jung Shan , Song Adelene Ai-Lian , Lim Renee Lay Hong , In Lionel Lian Aun 
Published: April 2021

Background
KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers. To date, there are still no target-specific vaccines or drugs available against this genotype, thus reinforcing the need towards the development of targeted therapies such as immunotoxins.

Methods
This study aims to develop a recombinant anti-mKRAS scFv-fused mutant Hydra actinoporin-like-toxin-1 (mHALT-1) immunotoxin that is capable of recognizing and eradicating codon-12 mutated k-ras antigen abnormal cells. One G13D peptide mimotope (164-D) and one G12V peptide mimotope (68-V) were designed to elicit antigen specific IgG titres against mutated K-ras antigens in immunised Balb/c mice. The RNA was extracted from splenocytes following ELISA confirmation on post-immunized mice sera and was reverse transcribed into cDNA. The scFv combinatorial library was constructed from cDNA repertoire of variable regions of heavy chain (VH) and light chain (VL) fusions connected by a flexible glycine-serine linker, using splicing by overlap extension PCR (SOE-PCR). Anti-mKRAS G12V and G13D scFvs were cloned in pCANTAB5E phagemid and superinfected with helper phage. After few rounds of bio-panning, a specific mKRAS G12V and G13D scFv antibody against G12V and G13D control mimotope was identified and confirmed using ELISA without any cross-reactivity with other mimotopes or controls. Subsequently, the anti-mKRAS scFv was fused to mHALT-1 using SOE-PCR and cloned in pET22b vector. Expressed recombinant immunotoxins were analyzed for their effects on cell proliferation by the MTT assay and targeted specificity by cell-based ELISA on KRAS-positive and KRAS-negative cancer cells.

Results
The VH and VL genes from spleen RNA of mice immunized with 164-D and 68-V were amplified and randomly linked together, using SOE-PCR producing band sizes about 750 bp. Anti-mKRAS G12V and G13D scFvs were constructed in phagemid pCANTAB5E vectors with a library containing 3.4 × 106 and 2.9 × 106 individual clones, respectively. After three rounds of bio-panning, the anti-mKRAS G12V-34 scFv antibody against G12V control mimotope was identified and confirmed without any cross-reactivity with other controls using ELISA. Anti-mKRAS G12V-34 scFv fragment was fused to mHALT-1 toxin and cloned in pET22b vector with expression as inclusion bodies in E. coli BL21(DE3) (molecular weight of ~46.8 kDa). After successful solubilization and refolding, the mHALT-1-scFv immunotoxin exhibited cytotoxic effects on SW-480 colorectal cancer cells with IC50 of 25.39 μg/mL, with minimal cytotoxicity effect on NHDF cells.

Discussion
These results suggested that the development of such immunotoxins is potentially useful as an immunotherapeutic application against KRAS-positive malignancies.
Two-Parameter Nwikpe (TPAN) Distribution with Application
Authors: Nwikpe Barinaadaa John , Essi Isaac Didi 
Published: April 2021

A new two-parameter continuous distribution called the Two-Parameter Nwikpe (TPAN) distribution is derived in this paper. The new distribution is a mixture of gamma and exponential distributions. A few statistical properties of the new probability distribution have been derived. The shape of its density for different values of the parameters has also been established. The first four crude moments, the second and third moments about the mean of the new distribution were derived using the method of moment generating function. Other statistical properties derived include; the distribution of order statistics, coefficient of variation and coefficient of skewness. The parameters of the new distribution were estimated using maximum likelihood method. The flexibility of the Two-Parameter Nwikpe (TPAN) distribution was shown by fitting the distribution to three real life data sets. The goodness of fit shows that the new distribution outperforms the one parameter exponential, Shanker and Amarendra distributions for the data sets used for this study.
Analysis of Full Blood Count and Bone Marrow Aspirations at Presentation in Children Diagnosed with Acute Leukaemias – A Single Centre Experience in Southern Nigeria
Authors: Eke G. K. , Korubo K. I. 
Published: April 2021

Introduction: Acute leukaemias are the most common malignant neoplasms in childhood, presenting with a variety of nonspecific symptoms. Though many of the recent more sophisticated methods of diagnosis have important prognostic implications, they are often not available in low- and middle-income countries.
Objective: To review the full blood count and bone marrow aspirations at presentation in children diagnosed with acute leukaemias at a teaching hospital in southern Nigeria.
Methodology: A retrospective survey of children with acute leukaemias admitted into the Paediatric Oncology unit of the University of Port Harcourt Teaching Hospital (UPTH), from January 2014 to December 2020. Their clinical profile, full blood count and bone marrow aspirations were analyzed using SPSS version 25.0
Results: Forty-three children aged 8 months to 17 years, with a median age of 9 years, were diagnosed with acute leukaemia within the period under review, 28 (65.1%) were males and 15 (34.9%) females, giving a M:F ratio of 1.9:1. Commonest clinical features at presentation were fever (n=28, 65.1%), pallor (n=18, 41.9%) and gum bleeding (n=16, 37.2%); while 38 (88.4%) of them presented with anaemia, 20 (46.5%) had leukocytosis and 36 (83.7%) had thrombocytopoenia with a median platelet count of 42x109/L and circulating blasts were present in the peripheral blood film of most of the patients. Acute lymphoblastic leukaemia (ALL) was the diagnosis in 30 (70%) children, and AML in 9 (21%). The bone marrow was hypercellular in 30 cases (69.8%) and erythropoiesis was depressed in 39 (90.7%) children.
Conclusion: At the UPTH, children with acute leukaemias were mostly males. Fever, pallor and gum bleeding were the commonest symptoms with most of them having circulating blasts. Acute lymphoblastic leukaemia was the commonest type and bone marrow was mainly hypercellular with depressed erythropoiesis.
Side‐Chain Engineering on Y‐Series Acceptors with Chlorinated End Groups Enables High‐Performance Organic Solar Cells
Authors: Chen Yuzhong , Ma Ruijie , Liu Tao , Xiao Yiqun , Kim Ha Kyung , Zhang Jianquan , Ma Chao , Sun Huiliang , Bai Fujin , Guo Xugang , Wong Kam Sing , Lu Xinhui , Yan He 
Published: April 2021

AbstractChemical modifications of non‐fullerene acceptors (NFAs) play vital roles in the development of high efficiency organic solar cells (OSCs). In this work, on the basis of the previously reported molecule named Y6‐1O, chlorination and inner side‐chain engineering are adopted to endow the corresponding devices with higher open‐circuit voltage (VOC) and short‐circuit current density (JSC) as well as good morphology for high fill factor (FF). As a result, the molecule named BTP1O‐4Cl‐C12 can help achieve a higher power conversion efficiency (PCE) of 17.1% than that of Y6‐1O (16.1%). Furthermore, the following comparisons between BTP1O‐4Cl‐C12 and the two symmetric acceptors named BTP2O‐4Cl‐C12 and BTP‐4Cl‐C12 demonstrate the effect of asymmetric alkoxy substitution on the outer side chains, which not only achieves a balance between VOC and JSC, but also help obtain appropriate morphology for efficient charge dissociation and suppressed charge recombination. Therefore, the asymmetric BTP1O‐4Cl‐C12 can achieve a higher PCE compared to the symmetric BTP2O‐4Cl‐C12 and BTP‐4Cl‐C12. The work not only reports an excellent NFA for high‐performance OSCs, but also puts forward a series of methods for consecutive chemical modifications on Y‐series acceptors, which can be further applied to boost the PCE of OSCs to a higher level.
Recyclable Organocatalysts in Asymmetric Synthesis
Authors: Susam Zeynep Dilşad , Tanyeli Cihangir 
Published: April 2021

AbstractChiral organocatalysts are extensively in demand over the past 30 years for the synthesis of asymmetric compounds with remarkable stereoselectivities in high yields. In addition to these great facilities, they are eco‐friendly, non‐toxic, highly stable, and inexpensive structures so that a tremendous amount of studies has been developing. Besides, recyclable organocatalyst studies are of great interest to develop their environmental‐friendly feature lately. Increasing the usage of these catalysts by saving the asymmetric results could become the most desirable characteristic in near future. This survey summarizes the following studies that have been done so far to enlight this subject and our headlights cover‐up silica supported organocatalysts, polymer supported organocatalysts, magnetic nanoparticle supported organocatalysts, gold nanoparticle supported organocatalysts, ionic liquids organocatalysts and fluorous supported organocatalysts.
New generation drug eluting stents: Closing the gap in sex disparity in cardiovascular outcomes in women
Authors: Quesada Odayme , Henry Timothy D. 
Published: April 2021

Key Points
Use of the novel COMBO stent, circumferentially coated with anti‐CD34 antibodies to promote endothelialization and decrease inflammation led to extremely low 1‐year event rates with no sex differences .
Technological advances in new generation drug‐eluting stents has closed the gap in sex disparities for cardiovascular outcomes.
Women continue to be underrepresented in clinical trials and there is room to improve procedure related aspects such as radial access and potent antiplatelet therapy.
Gender and left atrial appendage occlusion: Not the exception in cardiovascular procedures
Authors: Belardi Jorge A. , Lamelas Pablo M. 
Published: April 2021

Key Points
Gender disparities have been described in many cardiovascular procedures, but reports about left atrial appendage occlusion are limited.
In a large national database, women were associated with lower utilization and worse clinical results.
There is a need to better understand the root of the observed gender disparities and interventions to reverse it.
Postponing cardiac procedures during the pandemic: The balance between elective and selective!
Authors: Garzon Stefano , Lemos Pedro A. 
Published: April 2021

Key Points
What the article teaches:Postponing elective cardiac procedures may have an adverse impact on short‐term outcomes.

How it will impact practice:Elective patients scheduled for cardiac procedures have different risk profiles and the decision for postponing should take into consideration the chances of complications related to the deferral.

What new research would help answer the question:Better validate tools to identify which subsets are more prone to early complications in case a scheduled invasive procedure is suspended.
Zinc Anodizing: Structural Diversity of Anodic Zinc Oxide Controlled by the Type of Electrolyte
Authors: Engelkemeier Katja , Sun Aijia , Voswinkel Dietrich , Grydin Olexandr , Schaper Mirko , Bremser Wolfgang 
Published: April 2021

AbstractAnodic zinc oxide (AZO) layers are attracting interdisciplinary research interest. Chemists, physicists and materials scientists are increasingly devoting attention to fundamental and application‐related research on these layers. Research work focuses on the application as semiconductor, corrosion protector, adhesion promoter, abrasion protector, or antibacterial surfaces. The structure and crystallinity essentially determine the properties of the AZO coatings. The type and concentration of the electrolyte, the applied current density or voltage as well as the duration time enable layer structures of structural variety. The article gives an overview of the different possibilities of anodic treatment, whereby the voltage and the current type are the main distinguishing criteria. Presented is the electrolytic oxidation (anodizing) and the electrolytic plasma oxidation (EPO). The electrolytic etching is also a process of anodic treatment. However, it does not produce AZO layers, but rather a degradation of the zinc layer. The review article shows the parameters used so far (electrolyte, current type, current density, voltage) and points out the influence on the formation of AZO structures in dependency to the used electrolyte.
Enhanced Photoluminescence of Gold Nanoparticle‐Quantum Dot Hybrids Confined in Hairy Polymer Nanofibers
Authors: Singh Sajan , Raulo Avinash , Singh Ajeet , Mittal Mona , Horechyy Andriy , Hübner René , Formanek Petr , Srivastava Rajiv K. , Sapra Sameer , Fery Andreas , Nandan Bhanu 
Published: April 2021

AbstractIn the present work, we have studied the influence of gold nanoparticles (AuNPs) on the photoluminescence (PL) behavior of cadmium selenide (CdSe) quantum dots (QDs) confined in spatially separated soft nanoscale cylindrical domains. These cylindrical domains, in the form of hairy core‐shell nanofibers, were fabricated via cooperative self‐assembly of polystyrene‐block‐poly(4‐vinylpyridine) (PS‐b‐P4VP) block copolymer (BCP) mixed with pre‐synthesized CdSe QDs and AuNPs. The CdSe QDs and AuNPs were simultaneously incorporated in the P4VP cylindrical domains of the self‐assembled BCP structure. It was found that the confinement imposed by the nanometer‐sized cylindrical core resulted in the localization of the CdSe QDs and AuNPs in close proximity. Notably, it was observed that the PL intensity of the CdSe QDs could be manipulated by varying the amount of AuNPs present in the cylinder core. Interestingly, in the presence of a very low fraction of AuNPs, the PL intensity of the CdSe QDs increased compared to the AuNPs‐free system. However, further increase in the fraction of AuNPs led to gradual quenching of the photoluminescence intensity. The PL enhancement and quenching plausibly was due to the interplay between the energy transfer due to surface plasmon coupling and FRET/electron transfer from QDs to the AuNPs. The resulting functional nanofibers could have potential applications in sensing, bioimaging, and optoelectronic devices.