bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Surgery Under Cardiopulmonary Bypass in Pregnancy: Report of Four Cases
Authors: You Youhao , Liu Shenghua , Wu Zhaohong , Chen Dunjin , Wang Gefei , Chen Gangdong , Pan Youguang , Zheng Xing 
Published: July 2021

Abstract
Background: Open heart surgery during pregnancy is relatively rare at home and abroad, with high risk and high probability of maternal and infant death. How to carry out heart valve replacement under cardiopulmonary bypass (CPB) under the condition of ensuring the safety of mother and child is a focus of attention at home and abroad. Case introduction: We reported four cases of pregnant women who underwent cardiac surgeries under CPB during pregnancy in our hospital. Three cases had infective endocarditis (IE), who underwent heart valve placement with mechanical mitral valve, and one case with ascending aortic aneurysm underwent Bentall surgery. The operations of four cases were successful, and further follow-up evaluation of the pregnant women and fetus showed no abnormality. Patients' details are available in the following table. Conclusion: Actively and proactively for heart disease during pregnancy with obvious symptoms. Cardiac valve replacement under CPB will be the first choice, and this may become the primary surgical treatment for symptomatic heart diseases during pregnancy.
Record performance of ultralow-temperature-driven water-based sorption refrigeration enabled by low-cost zeolite-like porous aluminophosphate
Authors: liu Zhang Li , Xu Jiaxing , Min Xu , Huang Caifeng , Wang Ruzhu , Li Tingxian , Huai Xiulan 
Published: July 2021

Abstract
Thermally driven water-based sorption refrigeration is considered a promising strategy to realize near-zero-carbon cooling applications by addressing the urgent global climate challenge caused by conventional chlorofluorocarbon (CFC) refrigerants. However, developing cost-effective and high-performance water-sorption porous materials driven by low-temperature thermal energy is still a significant challenge. Here, we propose a low-cost zeolite-like aluminophosphate with SFO topology (EMM-8) for water-sorption-driven refrigeration. The EMM-8 is characterized by 12-membered ring channels with large accessible pore volume and exhibits high water uptake of 0.36 g·g-1, low-temperature regeneration of 65 °C, fast adsorption kinetics, remarkable hydrothermal stability, and scalable fabrication. Importantly, the water-sorption-based chiller with EMM-8 shows the potential of achieving a record coefficient of performance (COP) of 0.85 at an ultralow-driven temperature of 63 °C. The extraordinary working performance makes EMM-8 a practical alternative to realize high-efficient ultra-low-temperature-driven refrigeration.
Fall Prevention in Community-Dwelling Adults with Mild to Moderate Cognitive Impairment: A Systematic Review and Meta-Analysis
Authors: Racey Megan , Markle-Reid Maureen , Fitzpatrick-Lewis Donna , Ali Muhammad Usman , Gagné Hélène , Hunter Susan , Ploeg Jenny , Sztramko Richard , Harrison Lisa , Lewis Ruth , Jovkovic Milos , Sherifali Diana 
Published: July 2021

Abstract
Background: Cognitive impairment (CI) increases an individual’s risk of falls due to the role cognition plays in gait control. Older adults with dementia fall 2-3 times more than cognitively healthy older adults and 60-80% of people with dementia fall annually. Practitioners require evidence-based fall prevention best practices to reduce the risk of falls in cognitively impaired adults living in the community. Methods: We conducted a systematic review and meta-analysis to identify the effectiveness of primary and secondary fall prevention interventions in reducing falls and fear of falling, and improving gait, balance, and functional mobility. We searched 7 databases for fall prevention interventions involving community-dwelling adults ≥50 years with mild to moderate CI. Reviewers screened citations, extracted data, and assessed risk of bias and certainty of evidence (GRADE). We assessed statistical and methodological heterogeneity and performed a meta-analysis of studies including subgroup analysis based on intervention and risk of bias groupings.Results: 509 community-dwelling adults (mean age 67.5 to 84.0 years) with mild to moderate CI from 12 randomized or clinical controlled trials (RCTs/CCTs) were included in this review. Eight studies were exercise interventions, 3 were multifactorial, and 1 provided medication treatment. Fall prevention interventions had significant effects of medium magnitude on fear of falling (standardized mean difference (SMD) -0.73 [-1.10, -0.36]), balance (SMD 0.66 [0.19, 1.12]), and functional mobility measured as Timed Up and Go test (SMD -0.56 [-0.94, -0.17]) and significant effects of small magnitude on gait control (SMD 0.26 [0.08, 0.43]) all with moderate certainty of evidence. The meta-analysis showed no significant effects for falls (number of events or falls incidence). Sub-analysis showed that exercise and low risk of bias studies remained significant for balance and perceived risk of falls.Conclusion: The effect of fall prevention interventions on direct outcomes, such as falls, remains unclear in cognitively impaired individuals. Exercise interventions are effective at improving fall risk factors, however, high quality studies with longer follow-up and adequate sample sizes are needed to determine their effectiveness on falls directly. There remains a gap in terms of effective fall prevention interventions for older adults with CI.
Environmental Protection Investment and Enterprise Innovation: Evidence from Chinese Listed Companies
Authors: Jiang Xinfeng , Akbar Ahsan , Hysa Eglantina , Akbar Minhas 
Published: July 2021

Abstract
China has emerged as the world’s second-largest economy due to its rapid industrial expansion and phenomenal economic growth in recent decades. Though, this exponential economic turnaround has been fueled by widespread energy consumption, making China among the largest pollutant emitters in the world. Chinese enterprises have come under greater scrutiny and the government has mandated Chinese companies to undertake environmental protection investment. However, little is known that how these mandatory environmental investments affect Chinese firms’ ability to undertake R&D expenditures. This study employs data of China’s A-share listed firms during 2008-2016 to examine the nexus between environmental protection investment and corporate innovation. Our findings conjecture the crowding-out effects of environmental investments on enterprise innovation-related expenditures. Furthermore, additional empirical testing reveals that R&D undertakings of state-owned and politically connected firms are not affected by environmental investments. Likewise, corporate innovation activities are not negatively influenced by environmental investments in polluting industries. The study findings offer fresh insights to regulators, corporate managers, and stakeholders. Our results are robust to alternate econometric specifications and alternate variable specifications.
WITHDRAWN: Removal of MTBE From Groundwater Using A PRB of ZVI/Sand Mixtures: Role of Nitrate And Hardness
Authors: Ghayurdoost Farhad , Assadi Ali , Mehrasbi Mohammad Reza 
Published: July 2021

Abstract
In this study, the efficiency of the permeable reactive barrier (PRB) in a column reactor using zero-valent iron (ZVI) particles and sand mixture in the removal of methyl tert-butyl ether (MTBE) from aquatic phases was investigated. The main operating parameters influence reactor performance such as pH, reaction time, pollutant content, catalyst load, hydraulic loading rate, and the reaction rate constant was evaluated. The results showed that the efficiency of process decreased with increasing pH, inflow, and pollutant concentration. In this case, the optimal conditions were obtained at pH=7, flow rate=0.23 m3/m2.d and C0=1 mg/L, which achieved a remarkable removal efficiency up to 90.32%. The being of high nitrate and hardness concentrations as intervening factors were led to reduce process efficiency to less than 44.61% and 51.4%, respectively. Lack of interfering factors had a considerable effect on the reaction rate of MTBE reduction that is approximately 2.65 and 4.11 times higher than in the presence of calcium hardness and nitrate, respectively. The PRB can be operated to remediate groundwater containing hydrocarbons based on filling media and hydraulic conditions.
Systematic Analyses of The Role of Prognostic And Immunological of EIF3A, A Reader Protein, In Clear Cell Renal Cell Carcinoma
Authors: Zhang Yi , Hua Xiaoliang , Shi Haoqiang , Zhang Li , Xiao HaiBing , Liang Chaozhao 
Published: July 2021

Abstract
Background: Eukaryotic initiation factor 3a, EIF3A, as a “reader” protein for RNA methylation, has been found to be related to promote tumorigenesis in different variety of cancers. The impaction of EIF3A in clear cell renal cell carcinoma (ccRCC) has yet to be expounded. This study aimed to identify the prognostic value of EIF3A in ccRCC and investigate the relationship between expression and immune infiltration.Methods: We collected 29 m6a related mRNA data and clinicopathological parameters from Cancer Genmoe Atlas (TCGA) database. Logistic regression analyses were used to analyze the correlation between EIF3A expression and clinical characteristics. Immunohistochemistry (IHC) were applied to examine EIF3A levels in normal and ccRCC tissues. Univariate and multivariate analyses were conducted to recognize forcefully independent factor in associated with overall survival (OS) and diseases free survival (DFS). Nomogram was aim at predicting the 1-, 3-and 5-year survival probabilities. Gene set enrichment analysis (GSEA) was carried out to the potential function and related signaling pathways of EIF3A expression. To investigate EIF3A of co-expressed genes, we used LinkedOmics and its result was undertaken enrichment analysis. Simultaneously, to employ LinkedOmics and STRING dataset drew a conclusion that EIF3A co-expressed genes and visualized via Cytoscape. Finally, we evaluated that EIF3A expression correlated between with infiltration of immune cells and the expression of marker genes in ccRCC by Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA).Result: EIF3A expression was significantly different between ccRCC tissues and normal tissues. EIF3A expression was connected with poor prognostic clinicopathological factors, and K–M analyses revealed that low EIF3A expression was correlated with poor prognosis. The result of univariate and multivariate analyses proved that EIF3A was a prognostic factor in ccRCC patients. GSEA results indicated that high expression was enriched in renal cell carcinoma pathway and so on. EIF3A expression was significantly positively correlated with B cells, CD8+T cells, CD4+T cells, neutrophils, macrophages, and dendritic cells. Furthermore, EIF3A expression was associated with most of marker genes of immune cells.Conclusions: EIF3A could serve as potential biomarkers for prognostic and diagnostic stratification factor for ccRCC and is related with immune cells infiltrates.
Rapid and Efficient Testing of The Toxicity of Graphene-Related Materials in Primary Human Lung Cells
Authors: Frontiñán-Rubio Javier , Jehová-González Viviana , Vázquez Ester , Durán-Prado Mario 
Published: July 2021

Abstract
Background

Graphene and its derivative materials are manufactured by numerous companies and research laboratories, during which processes they can come into contact with their handlers’ physiological barriers—for instance, their respiratory system. Despite their potential toxicity, these materials have even been used in face masks to prevent COVID-19 transmission. The increasingly widespread use of these materials requires the design and implementation of appropriate, versatile, and accurate toxicological screening methods to guarantee their safety. Murine models are adequate, though limited when exploring different doses and lengths of exposure—as this increases the number of animals required, contrary to the Three R’s principle in animal experimentation. This article proposes an in vitro model using primary, non-transformed normal human bronchial epithelial (NHBE) cells as an alternative to the most widely used model to date, the human lung tumor cell line A549. The model has been tested with three graphene derivatives—graphene oxide (GO), few-layer graphene (FLG), and small FLG (sFLG).
Results

We observed a cytotoxic effect (necrosis and apoptosis) at early (6- and 24-hour) exposures, which intensified after seven days of contact between cells and the graphene-related materials (GRMs)—with cell death reaching 90% after a 5 µg/mL dose. A549 cells are more resistant to necrosis and apoptosis, yielding values less than half those of NHBE cells at low concentrations of GRMs (between 0.05 and 5 µg/mL). Indeed, GRM-induced cell death in NHBE cells is comparable to that induced by toxic compounds such as diesel exhaust particles on the same cell line.
Conclusions

We propose NHBE as a suitable model to test GRM-induced toxicity, allowing refinement of the dose concentrations and exposure timings for better-designed in vivo mouse assays.
Diagnostic Efficiency of Adropin As A Preliminary Test To Exclude Acute Pulmonary Embolism
Authors: Orun Serhat , Celikkol Aliye , Basol Batuhan Ilbey , Yeniay Elif 
Published: July 2021

Abstract
Background
This study aimed to investigate the efficiency of adropin as a biomarker to exclude the diagnosis of acute pulmonary embolism (PE).
Methods
Patients presenting to the emergency department (ED) of a tertiary health center (a university hospital) between August 2019 and August 2020 and diagnosed with PE were included in this prospective cohort study. The amount of serum adropin was determined in patients with PE (who were diagnosed using computerized tomography pulmonary angiography) and compared with healthy volunteers.
Results
There were 57 participants in the study (28 controls and 29 PE patients). The mean adropin level of the PE group was 187.33 ± 62.40 pg/ml and significantly lower than the control group (524.06 ± 421.68 pg/ml) (p = 0.000). When the optimal adropin cut-off value was 213.78 pg/ml, the likelihood ratio of the adropin test was 3.4, and the sensitivity of the adropin test at this value was 82% with specificity of 75% (95% CI; AUC: 0.821). Further, the highest likelihood ratio obtained was 13.5, where the cut-off value was 304 pg/ml, the sensitivity of the test was 46%, and the specificity of the test was 96% (95% CI, AUC: 0.821).
Conclusion
The adropin test can be used to exclude the diagnosis of acute pulmonary embolism in the ED. However, more research is required to verify and support the generalizability of our study results.
The Chinese Version of The Quality of Life in Childhood Epilepsy Questionnaire-16-C (QOLCE-16-C): Translation, Validity, and Reliability
Authors: Tang Ping , Lu Qunfeng , Tang Wenjuan , Li Aiqiu , Sun Xiaomin , Sun Jingmin , Wang Lin , Jiang Yan , Yang Jie , Yang Liling , ji Jianlin 
Published: July 2021

Abstract
BackgroundEpilepsy is one of the most common chronic neurological diseases that adversely impact the quality of life of patients and their families. The 16-item measure of the Quality of Life Childhood Epilepsy Questionnaire (QOLCE-16) was designed to assess health-related quality of life (HRQOL) among children with epilepsy. The purpose of the study was to translate and evaluate psychometric properties of the QOLCE-16.MethodsThe 10 steps of Principles of Good Practices for translation and cultural adaptation of measures were adopted to translate the QOLCE-16 into Chinese. After that, item analysis, internal consistency, test-retest reliabilities, content validity and construct validity were conducted to test its applicability in children with epilepsy under the culture of China.ResultsA total of 414 objects were enrolled in our study. The results of item analysis showed the QOLCE-16-C had good discrimination, and each item was significantly related to the total scale (P<0.001). The Cronbach’s α value was 0.938 and the Test-retest reliability was 0.724. For validity, results showed that the QOLCE-16-C had good content validity. Exploratory factor analysis indicated it was reasonable that the QOLCE-16-C consists of four dimensions after rotation. Confirmatory factor analysis demonstrated good validity (χ2/df = 1.698, GFI = 0.913, CFI = 0.974, RMSEA = 0.058).ConclusionThe Chinese version of QOLCE-16-C appears to be a culturally appropriate, valid and reliable tool to assess the health-related quality of life of children with epilepsy in China.
Protopine Triggers Apoptosis Via The Intrinsic Pathway and Regulation of ROS/PI3K/Akt Signalling Pathway in Liver Carcinoma
Authors: Zhang Enfan , Nie Chunhui , Wang Bei , Wang Baoquan , Lv Ning , Yu Rui 
Published: July 2021

Abstract
Background: Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of this study is to examine the effects of protopine on liver carcinoma cells both in vitro and in vivo.Methods: MTT assay was performed to measure the cell viability. Wound healing and transwell assays were conducted to assess the motility of cells. Cellular apoptosis and ROS levels were measured by the flow cytometry. Western blotting assay was used to measure the change of proteins. The cytotoxicity of protopine was also evaluated in xenograft mice.Results: Protopine inhibited viabilities and triggered apoptosis via the intrinsic pathway in a caspase-dependent manner in liver carcinoma cells. Furthermore, protopine also induced accumulation of intracellular ROS which further led to the inhibition of PI3K/Akt signalling pathway. Finally, in vivo study showed that protopine also repressed tumour growth in xenograft mice without noticeable toxicity.Conclusions: Protopine might be used as a potential therapeutic agent for the treatment of liver carcinoma.
Inflammatory Pattern of Eosinophilic COPD Involving 12/15-LOX Lipid Signals Expressed by Eosinophils
Authors: Cai Chuanxu , Wang Shuyan , Yue Huakui , Zhan Danting , Zha Yimin , Zhu Bingyi , Ye Yutian 
Published: July 2021

Abstract
Background and objective:Eosinophilic chronic obstructive pulmonary disease (COPD) has been recognized as an inflammatory pattern which is importance for precise treatment interventions among COPD. However, the studies about eosinophilic COPD show conflicting results and the role of eosinophils in COPD remains unclear. In this study, LC-MS/MS-based mediator lipidomics was to determine the expression status of lipid signals in non-eosinophilic and eosinophilic COPD.Method:A totally 80 patients with COPD including 40 eosinophilic COPD and 40 non-eosinophilic COPD were enrolled over 12 months. Clinical characteristics information record, pulmonary function tests, complete blood count, serum metabolites analysis and other clinical tests were performed at baseline and follow-up. Results:There were no significant differences in pulmonary function or pulmonary function decline between eosinophilic COPD and non-eosinophilic COPD after follow-up. However, eosinophilic COPD have higher numbers of acute exacerbation patient in the last 1 year. Complete blood count (CBC) data demonstrated that Δblood eosinophil count (BEC) was significantly decreased and correlated with ΔFEV1 (% Predicted) (r = 0.314, P = 0.036) in eosinophilic COPD. Furthermore, compared to non-eosinophilic COPD, a series of 12/15-LOX-derived mediators were found increased in eosinophilic COPD. Among them, 17-HDoHE was found significantly decreased after follow-up and significantly correlated with ΔBEC (r= 0.336, P= 0.023).Conclusion:This study demonstrates that metabolic levels of non-eosinophilic COPD and eosinophilic COPD were different due to the huge difference in eosinophil level, which leads to different inflammatory patterns, and the 12/15-LOX metabolic pathway was one of them. The results might help to understand the inflammatory response and lipid metabolism of eosinophilic COPD.
Resolution of Unexplained Iron Deficiency Following Successful Eradication of Helicobacter Pylori in Children
Authors: Tanous Osama , Levin Carina , S.Suchdev Parminder , Luo Hanqi , Rinawi Firas 
Published: July 2021

Abstract
Background: Evidence is needed to inform whether Helicobacter pylori (HP) treatment is beneficial in children with refractory iron deficiency. We aimed to assess association between successful HP eradication and resolution of unexplained iron deficiency. Methods: Medical records of children diagnosed with HP infection (based on histopathology) and without significant upper gastrointestinal source of blood loss, were retrospectively reviewed for presence of iron deficiency. Among those with non-anemic iron deficiency (NAID) or iron deficiency anemia (IDA), hemoglobin, ferritin and C-reactive protein (CRP) levels were compared prior and 6-9 months’ post successful HP eradication. Patients with overt bleeding or subsequent iron supplement therapy post HP diagnosis were excluded. Predictors of resolution of iron deficiency following HP eradication were assessed. Results: Among 60 included children (median age 14.8, IQR12.3-16; 62% males), symptoms of anemia were observed in 20%. A total of 21 (35%) had IDA while the remainder 65% had NAID. Following successful HP eradication, 60% of these 60 patients normalized their iron status. There were significant improvements in both hemoglobin and ferritin following HP eradication with hemoglobin increasing from 12.3g/dL to 13.0 g/dL (P<0.001), and ferritin increasing from 6.3μg/l to 15.1 μg/l (P<0.001). In multivariate logistic regression that assessed sex, ethnicity, baseline hemoglobin, anemia or GI symptoms, previous iron therapy, and time from diagnosis to eradication, older age was the only factor associated with resolution of anemia following HP eradication: (OR 1.65, 95% CI 1.16-2.35, P = 0.005).Conclusion: Successful HP eradication could be helpful in improving iron status among children with refractory NAID or IDA. Older age may predict this outcome. Screening for HP should be considered in the workup of refractory IDA or NAID.
Geopotential-based Multivariate MJO Index: Extending RMM-like Indices to Pre-Satellite Era
Authors: Leung Jeremy Cheuk-Hin , Qian Weihong , Zhang Peiqun , Zhang Banglin 
Published: July 2021

Abstract
Model simulations suggest that Madden-Julian Oscillation (MJO) activity changes under the anthropogenic climate change background. However, satellite observations, which provide information of MJO convection activity, are not available before the 1970s, hindering research on the historical long-term variability of MJO. This study aims at extending the data length of MJO indices that include both MJO circulation and convection features, such as the widely used Real-Multivariate MJO (RMM) index, to the pre-satellite era. This paper introduces a new MJO index construction method, of which the outgoing longwave radiation (OLR) input is derived from upper-level geopotential, and names it as the Geopotential-based Multivariate MJO (GMM) index. The GMM index is derived over 1902–2008 and compared with the filtered version of RMM (FMM) index during 1981–2008. The GMM index is shown to (1) have the same climatological properties as the FMM index, (2) be statistically highly correlated to the FMM index, and (3) be able to indicate MJO activities and its convection features in the pre-satellite era. The overall bivariate correlation between FMM index and GMM index based on ERA-20C ranges from 0.959 to 0.968 in different phases. Evaluation results confirm the validity of the proposed MJO index construction method, which could capture MJO convection activity in the pre-satellite era and can be applied to all MJO indices that require input of OLR. This study provides an alternative way that overcomes the difficulty of historical MJO studies, and will be beneficial to our understanding of the long-term change of MJO.