bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice Tools for Screening and Monitoring Insomnia in Children and Adolescents with Autism Spectrum Disorder
Authors: Banaschewski Tobias , Bruni Oliviero , Fuentes Joaquin , Hill Catherine Mary , Hvolby Allan , Posserud Maj-Britt , Schroder Carmen 
Published: August 2021

AbstractBetween 50–80% of children with autism spectrum disorder (ASD) have insomnia, which adversely affects their mental and physical health. However, there is no consensus to-date on suitable tools for insomnia screening and monitoring in daily clinical practice. An expert panel of child neuropsychiatry and sleep specialists, with expertise in children with neurodevelopmental disabilities, recommends: (1) performing insomnia screening of all children with ASD; (2) considering discussion or referral to a sleep specialist when comorbid sleep disorders are suspected. The panel further developed structured, brief screening and monitoring tools to facilitate insomnia screening and management in daily practice, monitor treatment effectiveness and standardize and compare outcomes across clinical settings to improve care and well-being of children with ASD and their families.
Estetrol and Mammary Gland: Friends or Foes?
Authors: Gallez Anne , Dias Da Silva Isabelle , Wuidar Vincent , Foidart Jean-Michel , Péqueux Christel 
Published: August 2021

AbstractEstrogens have pleiotropic effects on many reproductive and non-reproductive tissues and organs including the mammary gland, uterus, ovaries, vagina, and endothelium. Estrogen receptor α functions as the principal mediator of estrogenic action in most of these tissues. Estetrol (E4) is a native fetal estrogen with selective tissue actions that is currently approved for use as the estrogen component in a combined oral contraceptive and is being developed as a menopause hormone therapy (MHT, also known as hormone replacement therapy). However, exogenous hormonal treatments, in particular MHTs, have been shown to promote the growth of preexisting breast cancers and are associated with a variable risk of breast cancer depending on the treatment modality. Therefore, evaluating the safety of E4-based formulations on the breast forms a crucial part of the clinical development process. This review highlights preclinical and clinical studies that have assessed the effects of E4 and E4-progestogen combinations on the mammary gland and breast cancer, focusing in particular on the estrogenic and anti-estrogenic properties of E4. We discuss the potential advantages of E4 over current available estrogen-formulations as a contraceptive and for the treatment of symptoms due to menopause. We also consider the potential of E4 for the treatment of endocrine-resistant breast cancer.
SymptomSpeak: Women’s Struggle for History and Health in Kosovo
Authors: Kienzler Hanna 
Published: August 2021

AbstractWhat are the linguistic dimensions of pain, and what kind of articulations arise from these painful experiences? How does the language of pain circulate, connect, and reach across histories, gendered realities, and social politics? In what ways might the language of pain act on and transform the world by shaping and changing socio-political agendas? I explored these questions among women in Kosovo and discovered a unique symptomatic language which I call SymptomSpeak. SymptomSpeak is a powerful language evoked, shared, and exchanged by women to articulate political, social, and economic grievances, to challenge societal norms, and to demand justice. The language itself consists of a detailed symptom vocabulary which is variously assembled into meaning complexes. Such assemblages shift depending on the social context in which they are conveyed and are referred to asnervoz(nervousness),mërzitna(worried, sad),mzysh(evil eye), andt’bone(spell). I describe in detail how women variously combine and exchange components of SymptomSpeak and, thereby, question dominant framings of reality. Thereby, my intention is to contribute to a new understanding of pain as language which straddles the fine line between socio-political commentary and illness; produces gendered political realities; and challenges the status quo through its communicative power.
Quantification of dwarfing effect of different rootstocks in ‘Picual’ olive cultivar using UAV-photogrammetry
Authors: Torres-Sánchez Jorge , de la Rosa Raúl , León Lorenzo , Jiménez-Brenes Francisco M. , Kharrat Amal , López-Granados Francisca 
Published: August 2021

AbstractHedgerow orchard is an olive growing system where trees are planted at a super high-density higher than 20-fold (i.e., 1200–2500 trees ha−1) compared to the traditional density of olive orchards (usually 50 to 160 trees ha−1). It is dominating a great proportion of new plantations because harvesting can be fully mechanized, it is early bearing and has a relatively constant high productivity. However, there are a limited number of cultivars with sufficiently low vigour to be suitable for such plantation densities. For that reason, a set of low vigour cultivars and breeding selections has been used in a field experiment as rootstocks for reducing the vigour of “Picual”, the most frequent cultivar planted in Spain. Tree vigour was characterized by measuring crown height, projected and side areas, and volume through the analysis of photogrammetric point clouds created from images acquired with an unmanned aerial vehicle. A significant reduction of the ‘Picual’ vigour was observed in most of the rootstocks tested, with canopy volume reduced up to one half. High variability on vigour, first harvesting and their relative relationship was observed between the different rootstocks used. This indicates there might be enough genetic variability to perform breeding selection for dwarfing rootstocks on ‘Picual’ olive cultivar.
Long-Term Nitrogen and Phosphorus Dynamics in Waters Discharging from Forestry-Drained and Undrained Boreal Peatlands
Authors: Nieminen Mika , Sarkkola Sakari , Hasselquist Eliza Maher , Sallantaus Tapani 
Published: August 2021

AbstractContradictory results for the long-term evolution of nitrogen and phosphorus concentrations in waters discharging from drained peatland forests need reconciliation. We gathered long-term (10–29 years) water quality data from 29 forested catchments, 18 forestry-drained and 11 undrained peatlands. Trend analysis of the nitrogen and phosphorus concentration data indicated variable trends from clearly decreasing to considerably increasing temporal trends. While the variations in phosphorus concentration trends over time did not correlate with any of our explanatory factors, trends in nitrogen concentrations correlated positively with tree stand volume in the catchments and temperature sum. A positive correlation of increasing nitrogen concentrations with temperature sum raises concerns of the future evolution of nitrogen dynamics under a warming climate. Furthermore, the correlation with tree stand volume is troublesome due to the generally accepted policy to tackle the climate crisis by enhancing tree growth. However, future research is still needed to assess which are the actual processes related to stand volume and temperature sum that contribute to increasing TN concentrations.
Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients
Authors: Advani Pooja , Chumsri Saranya , Pai Tanmayi , Li Zhuo , Sharma Akash , Parent Ephraim 
Published: August 2021

Abstract
Background
mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET.

Methods
262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (ΔSUVmax).

Results
ΔSUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median ΔSUVmax of 2.6 (0–7 days), 0.8 (8–14 days), and 0.3 (> 14 days), respectively.

Conclusion
Consideration should be given to performing FDG PET at least 2 weeks after the COVID-19 vaccine.
Prevalence of mutations in BRCA and homologous recombination repair genes and real-world standard of care of Asian patients with HER2-negative metastatic breast cancer starting first-line systemic cytotoxic chemotherapy: subgroup analysis of the global BREAKOUT study
Authors: Koh Su-Jin , Ohsumi Shozo , Takahashi Masato , Fukuma Eisuke , Jung Kyung Hae , Ishida Takanori , Dai Ming-Shen , Chang Chuan-Hsun , Dalvi Tapashi , Walker Graham , Bennett James , O’Shaughnessy Joyce , Balmaña Judith 
Published: August 2021

Abstract
Background
The multinational BREAKOUT study (NCT03078036) sought to determine the prevalence of germline BRCA1/2 (gBRCA1/2) and somatic BRCA1/2 (sBRCA1/2) mutations and mutations in other homologous recombination repair (HRR) genes in women with HER2-negative metastatic breast cancer (MBC) starting first-line chemotherapy.

Methods
Genetic testing for gBRCA, sBRCA, and HRR gene mutations was performed in patients who started first-line chemotherapy for MBC in the last 90 days (341 patients across 14 countries) who were not selected based on risk factors for gBRCA mutations. We report data from the Asian cohort, which included patients in Japan (7 sites), South Korea (10 sites), and Taiwan (8 sites).

Results
Of 116 patients screened, 104 patients were enrolled in the Asian cohort. The median age was 53.0 (range 25–87) years. gBRCA1/2, gBRCA1, and gBRCA2 mutations were detected in 10.6% (11/104), 5.8% (6/104), and 4.8% (5/104) of patients, respectively; none had mutations in both gBRCA1 and gBRCA2. gBRCA1/2 mutations were detected in 10.0% (6/60) and 11.6% (5/43) of patients with hormone receptor-positive and triple-negative MBC, respectively. HRR gene mutations were tested in 48 patients without gBRCA mutations, and 5 (10.4%) had at least one HRR mutation in sBRCA, ATM, PALB2, and CHEK2.

Conclusion
We report for the first time the prevalence of gBRCA and HRR mutations in an Asian cohort of patients with HER2-negative MBC. Our results suggest that BRCA mutation testing is valuable to determine appropriate treatment options for patients with hormone receptor-positive or triple-negative MBC.

Study registration
NCT03078036.
Advances in nonlinear optical microscopy techniques for in vivo and in vitro neuroimaging
Authors: Pallen Sparsha , Shetty Yuthika , Das Subir , Vaz Joel Markus , Mazumder Nirmal 
Published: August 2021

AbstractUnderstanding the mechanism of the brain via optical microscopy is one of the challenges in neuroimaging, considering the complex structures. Advanced neuroimaging techniques provide a more comprehensive insight into patho-mechanisms of brain disorders, which is useful in the early diagnosis of the pathological and physiological changes associated with various neurodegenerative diseases. Recent advances in optical microscopy techniques have evolved powerful tools to overcome scattering of light and provide improved in vivo neuroimaging with sub-cellular resolution, endogenous contrast specificity, pinhole less optical sectioning capability, high penetration depth, and so on. The following article reviews the developments in various optical imaging techniques including two-photon and three-photon fluorescence, second-harmonic generation, third-harmonic generation, coherent anti-Stokes Raman scattering, and stimulated Raman scattering in neuroimaging. We have outlined the potentials and drawbacks of these techniques and their possible applications in the investigation of neurodegenerative diseases.
Temporal trends in the incidence rates of keratinocyte carcinomas from 1978 to 2018 in Tasmania, Australia: a population-based study
Authors: Ragaini Bruna S. , Blizzard Leigh , Newman Leah , Stokes Brian , Albion Tim , Venn Alison 
Published: August 2021

AbstractObjectivesWe described incidence trends of keratinocyte carcinomas (KCs)—namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)—in the Australian state of Tasmania.MethodsWe identified histologically confirmed KCs within the Tasmanian Cancer Registry (TCR) and conducted assessments to ensure data quality. Age-standardised incidence rates were calculated for first (1985–2018) and annual KCs (1978–2018). Average annual percentage changes were computed using Joinpoint regression models.ResultsThe TCR is a reliable source of KC data. A total of 83,536 people were registered with a KC between 1978 and 2018. Age-standardised incidence rates of first KCs increased on average by 3% per annum for BCCs and 4% per annum for SCCs, reaching 363/100,000 and 249/100,000 in 2018, respectively. Age-standardised incidence rates of annual KCs increased on average by 5% per annum for BCCs and 6% per annum for SCCs, up to 891/100,000 and 514/100,000 in 2018, respectively. This increase was steeper for females than males and highest during the late 1980s and early 1990s. A change in trend around 2014 suggested that incidence rates have started to decline.ConclusionWhile the incidence of KCs in Tasmania increased substantially over 41 years, rates have recently plateaued and started to decline. The findings may reflect changes in sun exposure behaviours due to awareness campaigns, but high incidence rates in 2018 indicate that KCs still pose a substantial burden to this population.
The SQALE of CSIDH: sublinear Vélu quantum-resistant isogeny action with low exponents
Authors: Chávez-Saab Jorge , Chi-Domínguez Jesús-Javier , Jaques Samuel , Rodríguez-Henríquez Francisco 
Published: August 2021

AbstractRecent independent analyses by Bonnetain–Schrottenloher and Peikert in Eurocrypt 2020 significantly reduced the estimated quantum security of the isogeny-based commutative group action key-exchange protocol CSIDH. This paper refines the estimates of a resource-constrained quantum collimation sieve attack to give a precise quantum security to CSIDH. Furthermore, we optimize large CSIDH parameters for performance while still achieving the NIST security levels 1, 2, and 3. Finally, we provide a C-code constant-time implementation of those CSIDH large instantiations using the square-root-complexity Vélu’s formulas recently proposed by Bernstein, De Feo, Leroux and Smith.
Transformation of coffee-growing landscapes across Latin America. A review
Authors: Harvey Celia A. , Pritts Alyssa A. , Zwetsloot Marie J. , Jansen Kees , Pulleman Mirjam M. , Armbrecht Inge , Avelino Jacques , Barrera Juan F. , Bunn Christian , García Javier Hoyos , Isaza Carlos , Munoz-Ucros Juana , Pérez-Alemán Carlos J. , Rahn Eric , Robiglio Valentina , Somarriba Eduardo , Valencia Vivian 
Published: August 2021

AbstractIn Latin America, the cultivation of Arabica coffee (Coffea arabica) plays a critical role in rural livelihoods, biodiversity conservation, and sustainable development. Over the last 20 years, coffee farms and landscapes across the region have undergone rapid and profound biophysical changes in response to low coffee prices, changing climatic conditions, severe plant pathogen outbreaks, and other drivers. Although these biophysical transformations are pervasive and affect millions of rural livelihoods, there is limited information on the types, location, and extent of landscape changes and their socioeconomic and ecological consequences. Here we review the state of knowledge on the ongoing biophysical changes in coffee-growing regions, explore the potential socioeconomic and ecological impacts of these changes, and highlight key research gaps. We identify seven major land-use trends which are affecting the sustainability of coffee-growing regions across Latin America in different ways. These trends include (1) the widespread shift to disease-resistant cultivars, (2) the conventional intensification of coffee management with greater planting densities, greater use of agrochemicals and less shade, (3) the conversion of coffee to other agricultural land uses, (4) the introduction of Robusta coffee (Coffea canephora) into areas not previously cultivated with coffee, (5) the expansion of coffee into forested areas, (6) the urbanization of coffee landscapes, and (7) the increase in the area of coffee produced under voluntary sustainability standards. Our review highlights the incomplete and scattered information on the drivers, patterns, and outcomes of biophysical changes in coffee landscapes, and lays out a detailed research agenda to address these research gaps and elucidate the effects of different landscape trajectories on rural livelihoods, biodiversity conservation, and other aspects of sustainable development. A better understanding of the drivers, patterns, and consequences of changes in coffee landscapes is vital for informing the design of policies, programs, and incentives for sustainable coffee production.
Tourism Developments Increase Tsunami Disaster Risk in Pangandaran, West Java, Indonesia
Authors: Nijman Vincent 
Published: August 2021

AbstractOn 17 July 2006, the tourist resort of Pangandaran on Java’s south coast was hit by a tsunami, resulting in 413 fatalities and severe damage to buildings. The tsunami resulted in major rebuilds with a focus on mass tourism. Assessments of the impact of a future tsunami focussed on building development and suggest limited change since 2006. This article presents a case study on the development of (largely domestic) tourism in Pangandaran and how this has increased the tsunami disaster risk. Tourist numbers were stable at about 900,000 visitors a year prior to the tsunami, down to slightly over 250,000 visitors a year in its aftermath, and from 2007 onwards numbers are doubling every three years to about 4 million visitors in 2019. The increase has been most pronounced during weekends. Prior to 2006, Pangandaran was characterized by wooden structures and one- and two-story buildings of clay-brick masonry; by 2019, 14 three to six-story hotels have been erected along the waterfront. With many more visitors, most of whom are unfamiliar with tsunami risks, and shelter facilities for less than a quarter of visitors during peak times, future impacts and the potential cost to life are considerably higher now than in 2006, especially if a tsunami were to hit over a weekend. All tourists upon arrival and throughout their stay should be better informed about the risks of tsunamis, and of the location of tsunami shelters and evacuation routes.
Prediction calculations for the first criticality of the HTR-PM using the PANGU code
Authors: She Ding , Xia Bing , Guo Jiong , Wei Chun-Lin , Zhang Jian , Li Fu , Shi Lei , Zhang Zuo-Yi 
Published: August 2021

AbstractThe high-temperature reactor pebble-bed module (HTR-PM) is a modular high-temperature gas-cooled reactor demonstration power plant. Its first criticality experiment is scheduled for the latter half of 2021. Before performing the first criticality experiment, a prediction calculation was performed using PANGU code. This paper presents the calculation details for predicting the HTR-PM first criticality using PANGU, including the input model and parameters, numerical results, and uncertainty analysis. The accuracy of the PANGU code was demonstrated by comparing it with the high-fidelity Monte Carlo solution, using the same input configurations. It should be noted that keff can be significantly affected by uncertainties in nuclear data and certain input parameters, making the criticality calculation challenge. Finally, the PANGU is used to predict the critical loading height of the HTR-PM first criticality under design conditions, which will be evaluated in the upcoming experiment later this year.
Mono- and Multi-Representational Learning of the Covariational Aspect of Functional Thinking
Authors: Rolfes Tobias , Roth Jürgen , Schnotz Wolfgang 
Published: August 2021

AbstractUsing multiple external representations is advocated for learning in STEM education. This learning approach assumes that multiple external representations promote richer mental representations and a deeper understanding of the concept. In mathematics, the concept of function is a prototypical content area in which multiple representations are used. However, there are hardly any experimental studies investigating the effect of learning functional thinking with multiple representations compared to learning with only one form of representation. Therefore, this article reports on a quasi-experimental intervention study with students from Grade 7, using three measurement time points. The study compared the multi-representational learning of functional thinking with both tables and graphs with mono-representational learning with either tables or graphs. The results show that multi-representational learning led to advantages in learning qualitative functional thinking. However, in quantitative functional thinking, learning with both graphs and tables did not result in higher learning gains than learning exclusively with graphs. Furthermore, students were better able to transfer their knowledge from graphs to tables than vice versa. The results also indicate that multi-representational learning requires more time than mono-representational learning but can lead to higher learning gains. In sum, the results show that the effect of learning with representations is a complex interaction process between learning content and the forms of representation.
Structure of epidemic models: toward further applications in economics
Authors: Kuniya Toshikazu 
Published: August 2021

AbstractIn this paper, we review the structure of various epidemic models in mathematical epidemiology for the future applications in economics. The heterogeneity of population and the generalization of nonlinear terms play important roles in making more elaborate and realistic models. The basic, effective, control and type reproduction numbers have been used to estimate the intensity of epidemic, to evaluate the effectiveness of interventions and to design appropriate interventions. The advanced epidemic models includes the age structure, seasonality, spatial diffusion, mutation and reinfection, and the theory of reproduction numbers has been generalized to them. In particular, the existence of sustained periodic solutions has attracted much interest because they can explain the recurrent waves of epidemic. Although the theory of epidemic models has been developed in decades and the development has been accelerated through COVID-19, it is still difficult to completely answer the uncertainty problem of epidemic models. We would have to mind that there is no single model that can solve all questions and build a scientific attitude to comprehensively understand the results obtained by various researchers from different backgrounds.
Shaping the Selves of “At Risk” Youth in Debt and Poverty in the Context of Economic Vulnerability
Authors: Mäkelä Kalle , Ikävalko Elina , Brunila Kristiina 
Published: August 2021

AbstractDrawing on two interrelated areas of youth work, outreach youth work as a place of coordination of work, social benefits and social services, and youth workshops as a place for work training for young people “at risk”, our aim in this article is to analyse how young people in poor financial circumstances are governed through policies and practices in these institutions in Finland. Based on ethnographic fieldwork and interviews with young people and professionals working with young people, we ask how the subjectivities of young people “at risk” (and particularly those in debt and poverty) are shaped in the context of economic vulnerability. This shaping is not only from top-down dimensional formation of a subject, but also from the multidimensional flow of power/knowledge via subjects that sometimes possess opportunities of acting otherwise, as delineated in the end of our analysis. In the context of ubiquitous neoliberal governmentality, we delineated a landscape of survival strategies for economically vulnerable young people in these power/knowledge relations.