bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Cognitive Behavioral Therapy on Mood Disorders, Sleep, Fatigue, and Quality of Life in Parkinson's Disease: A Systematic Review and Meta-Analysis
Authors: Luo Fangyi , Ye Mengfei , Lv Tingting , Hu Baiqi , Chen Jiaqi , Yan Junwei , Wang Anzhe , Chen Feng , He Ziyi , Ding Zhinan , Zhang Jian , Qian Chao , Liu Zheng 
Published: December 2021

Objective: The aim of this study was to perform a quantitative analysis to evaluate the efficacy of cognitive behavioral therapy (CBT) on mood disorders, sleep, fatigue, and its impact on quality of life (QOL) in Parkinson's Disease (PD).Methods: We searched for randomized controlled trials in three electronic databases. Fourteen studies, including 507 patients with PD, met the inclusion criteria. We determined the pooled efficacy by standard mean differences and 95% confidence intervals, using I2 to reveal heterogeneity.Results: The result showed CBT had a significant effect on depression [−0.93 (95%CI, −1.19 to −0.67, P &lt; 0.001)] and anxiety [−0.76 (95%CI, −0.97 to −0.55, P &lt; 0.001)]. Moderate effect sizes were noted with sleep disorders [−0.45 (95% CI, −0.70 to −0.20, P = 0.0004)]. There was no evident impact of CBT on fatigue or QOL. We found an intervention period &gt;8 weeks was advantageous compared with &lt;8 weeks, and CBT implemented in non-group was more effective than in group. Between the delivery methods, no significant difference was found.Conclusion: We found that CBT in patients with PD was an efficacious therapy for some non-motor symptoms in PD, but not efficacious for fatigue and QOL. These results suggest that CBT results in significant improvement in PD and should be used as a conventional clinical intervention.
SARS-CoV-2 Transmissibility Within Day Care Centers—Study Protocol of a Prospective Analysis of Outbreaks in Germany
Authors: Schienkiewitz Anja , Jordan Susanne , Hornbacher Anselm , Perlitz Hanna , Zeisler Marie-Luise , Sandoni Anna , Kubisch Ulrike , Wess Barbara , Kuttig Tim , Schaffrath-Rosario Angelika , Damerow Stefan , Rattay Petra , Varnaccia Gianni , Loer Anne-Kathrin M. , Wormsbächer Jan , Cohrdes Carolin , Wetzstein Matthias , Albrecht Stefan , Hey Isabell , Michel Janine , Schrick Livia , Gößwald Antje , Allen Jennifer , Schlaud Martin , Busch Markus A. , Butschalowsky Hans , Wernitz Jörg , Otte im Kampe Eveline , Buchholz Udo , Haas Walter , Schaade Lars , Wieler Lothar H. , Ziese Thomas , Lampert Thomas , Loss Julika 
Published: December 2021

Introduction: Until today, the role of children in the transmission dynamics of SARS-CoV-2 and the development of the COVID-19 pandemic seems to be dynamic and is not finally resolved. The primary aim of this study is to investigate the transmission dynamics of SARS-CoV-2 in child day care centers and connected households as well as transmission-related indicators and clinical symptoms among children and adults.Methods and Analysis: COALA (“Corona outbreak-related examinations in day care centers”) is a day care center- and household-based study with a case-ascertained study design. Based on day care centers with at least one reported case of SARS-CoV-2, we include one- to six-year-old children and staff of the affected group in the day care center as well as their respective households. We visit each child's and adult's household. During the home visit we take from each household member a combined mouth and nose swab as well as a saliva sample for analysis of SARS-CoV-2-RNA by real-time reverse transcription polymerase chain reaction (real-time RT-PCR) and a capillary blood sample for a retrospective assessment of an earlier SARS-CoV-2 infection. Furthermore, information on health status, socio-demographics and COVID-19 protective measures are collected via a short telephone interview in the subsequent days. In the following 12 days, household members (or parents for their children) self-collect the same respiratory samples as described above every 3 days and a stool sample for children once. COVID-19 symptoms are documented daily in a symptom diary. Approximately 35 days after testing the index case, every participant who tested positive for SARS-CoV-2 during the study is re-visited at home for another capillary blood sample and a standardized interview. The analysis includes secondary attack rates, by age of primary case, both in the day care center and in households, as well as viral shedding dynamics, including the beginning of shedding relative to symptom onset and viral clearance.Discussion: The results contribute to a better understanding of the epidemiological and virological transmission-related indicators of SARS-CoV-2 among young children, as compared to adults and the interplay between day care and households.
Development and Application of Nanoparticle-Nanopolymer Composite Spheres for the Study of Environmental Processes
Authors: Rauschendorfer Robert J. , Whitham Kyle M. , Summer Star , Patrick Samantha A. , Pierce Aliandra E. , Sefi-Cyr Haley , Tadjiki Soheyl , Kraft Michael D. , Emory Steven R. , Rider David A. , Montaño Manuel D. 
Published: December 2021

Plastics have long been an environmental contaminant of concern as both large-scale plastic debris and as micro- and nano-plastics with demonstrated wide-scale ubiquity. Research in the past decade has focused on the potential toxicological risks posed by microplastics, as well as their unique fate and transport brought on by their colloidal nature. These efforts have been slowed by the lack of analytical techniques with sufficient sensitivity and selectivity to adequately detect and characterize these contaminants in environmental and biological matrices. To improve analytical analyses, microplastic tracers are developed with recognizable isotopic, metallic, or fluorescent signatures capable of being identified amidst a complex background. Here we describe the synthesis, characterization, and application of a novel synthetic copolymer nanoplastic based on polystyrene (PS) and poly(2-vinylpyridine) (P2VP) intercalated with gold, platinum or palladium nanoparticles that can be capped with different polymeric shells meant to mimic the intended microplastic. In this work, particles with PS and polymethylmethacrylate (PMMA) shells are used to examine the behavior of microplastic particles in estuarine sediment and coastal waters. The micro- and nanoplastic tracers, with sizes between 300 and 500 nm in diameter, were characterized using multiple physical, chemical, and colloidal analysis techniques. The metallic signatures of the tracers allow for quantification by both bulk and single-particle inductively-coupled plasma mass spectrometry (ICP-MS and spICP-MS, respectively). As a demonstration of environmental applicability, the tracers were equilibrated with sediment collected from Bellingham Bay, WA, United States to determine the degree to which microplastics bind and sink in an estuary based of grain size and organic carbon parameters. In these experiments, between 80 and 95% of particles were found to associate with the sediment, demonstrative of estuaries being a major anticipated sink for these contaminants. These materials show considerable promise in their versatility, potential for multiplexing, and utility in studying micro- and nano-plastic transport in real-world environments.
Aprendizaje del Idioma Inglés en la universidad cubana: una prioridad para la formación de profesionales competentes
Authors: Fontes Guerrero Olga Lidia , González Agulló Liset , Rodríguez Sánchez Maylín 
Published: December 2021

El aprendizaje del idioma Inglés en la universidad cubana actual exige la formación de un profesional competente, en constante proceso de aprendizaje y socialización. Todo esto demanda el empleo de diversas estrategias por parte de los estudiantes para poder interactuar con un texto y convertirse en lectores competentes. Es por esto por lo que el objetivo de esta investigación es ilustrar a los docentes los procedimientos a emplear para desarrollar la comprensión lectora en función de la formación profesional del futuro maestro desde un enfoque que privilegia las oportunidades que brinda el aprendizaje cooperativo. En la realización de la investigación se aplicaron métodos que favorecen la sistematización de experiencias, basado en la práctica didáctico-metodológica y la observación como técnica empírica. Los procedimientos propuestos son el resultado fundamental de esta indagación.
PALABRAS CLAVE: aprendizaje del inglés; formación; profesionales competentes.
Learning of English Language at Cuban university: a priority for the training of competent professionals
ABSTRACT
Learning English language in the Cuban university demands the training of a competent professional in a constant process of learning and socialization. All these involve the use of various strategies by the students to interact with a text to become competent readers. That is why the objective of this researching is to illustrate the teaching procedures that could be used in the development of textual comprehension where cooperative learning can be effective in the professional training of the students from an approach that favors the opportunities brought by this type of learning. The research relies on methods that allow the systematization of experiences based on didactic-methodological and systematic practice, at the same time observation was also applied as an empirical technique.
KEYWORDS: learning English; training; competent professionals.
Diseño e implementación de un aula virtual en la asignatura Histología II
Authors: Nuñez Rodríguez Jose Antonio , Coelho de Torres Beatriz Guiomar , Argüello Delgado Alcira Marina 
Published: December 2021

En este artículo se describe la experiencia educativa del diseño e implementación del aula virtual de la asignatura Histología II a través de la plataforma Moodle, como complemento de las clases presenciales durante el lapso académico 2016-I (Abril-Septiembre) del plan de estudio Técnico Superior Universitario en Histotecnología dictado por la Universidad de Carabobo. Se trabajó en tres fases, la primera dedicada al diseño del aula mediante nueve unidades temáticas con sus respectivos recursos técnico-pedagógicos, constituidos por documentos descargables de las clases, microvídeos y laminario con cortes histológicos. Una segunda fase dedicada a la implementación del aula con 28 alumnos y una tercera fase de evaluación relacionada con las estadísticas de accesibilidad y uso de los recursos, así como una consulta a los estudiantes sobre el diseño, contenidos y actividades. Los resultados muestran que la utilidad práctica del aula virtual implementada se enfocó en un espacio para la revisión de los contenidos y no como un espacio para la construcción del conocimiento, existiendo estudiantes tímidos frente al cambio. Sin embargo, los recursos diseñados tuvieron un 78,5% de aceptación, mientras que las actividades sumativas propuestas, como crucigramas, infografías y mapas mentales tuvieron un 75% de aceptación.
PALABRAS CLAVE: Aprendizaje colaborativo; construcción del conocimiento; morfología microscópica; TIC.
Design and implementation of a virtual classroom in the Histology II subject
ABSTRACT
This article describes the educational experience of the design and implementation of the virtual classroom of the subject "Histology II" through the Moodle platform, as a complement to the face-to-face classes during the academic period 2016-I (April-September) of the Higher Technical University study in Histotechnology dictated by the University of Carabobo. Work was carried out in three phases, the first one dedicated to classroom design using nine thematic units with their respective technical-pedagogical resources, consisting of downloadable class documents, micro-videos and a laminar with histological sections. A second phase dedicated to the implementation of the classroom with 28 students and a third evaluation phase related to accessibility statistics and use of resources, as well as a consultation with students on design, content and activities. The results show that the practical usefulness of the implemented virtual classroom was focused on a space for the revision of the contents and not as a space for the construction of knowledge, there being shy students in the face of change. However, the designed resources had a 78.5% acceptance, while the proposed summative activities, such as crossword puzzles, infographics and mind maps had a 75% acceptance.
KEYWORDS: Collaborative learning; construction of knowledge; microscopic morphology; ICT.
Fluidez lectora para mejorar la comunicación en los escolares de segundo año de Educación General Básica de la Escuela Gran Colombia de Portoviejo, Manabí, Ecuador
Authors: Intriago Mendoza Luisana Monserrate , Calle García Robertson Xavier 
Published: December 2021

Fluidez lectora para mejorar la comunicación en los escolares de segundo año de Educación General Básica
AUTORES: [1]
Robertson Xavier Calle García[2]
DIRECCIÓN PARA CORRESPONDENCIA: luisanaim1983@hotmail.com

Fecha de recepción:

10

-

07

-

2020

Fecha de aceptación:

25

-

09

-

2020

RESUMEN
Entre las preocupaciones más notables que se destacan en los docentes, se describe que los conocimientos que brinda, éstos disminuyan las necesidades que tienen los escolares, que los conocimientos sean relevantes y necesarios, pero es más imprescindible destacar que la enseñanza de la lectura y a su vez la fluidez lectora sea de vital importancia para el logro de la comunicación en los escolares, sobre todo en los primeros años de estudios, ya que desde allí se forman los primeros conceptos, los que servirán a lo largo de su vida, por otra parte se debe señalar que es necesario que los padres acompañen y se comprometan en la preparación de sus hijos desde los hogares, reforzando los conocimientos que se imparten en la escuela, lo que conlleva que se conviertan en los pilares fundamentales para cumplir los retos más sagrados de sus representados, como es el de aprender, entender y comprender lo que él lee y lo que leen los demás.
PALABRAS CLAVE: Fluidez lectora; comprensión lectora; comunicación educativa.
Reading fluency to improve communication in second year students of Basic General Education of the Gran Colombia School of Portoviejo, Manabí, Ecuador

ABSTRACT
Among the most notable concerns that stand out in teachers, it is described that the knowledge it provides reduces the needs that schoolchildren have, that the knowledge is relevant and necessary, but it is more essential to highlight that the teaching of reading and its Perhaps reading fluency is of vital importance for the achievement of communication in schoolchildren, especially in the first years of studies, since from there the first concepts are formed, which will serve throughout their lives, on the other hand It should be noted that it is necessary for parents to accompany and commit to the preparation of their children from home, reinforcing the knowledge taught at school, which means that they become the fundamental pillars to meet the most sacred challenges of his represented, such as learning, understanding and understanding what he reads and what others read.
KEYWORDS: Reading fluency; reading comprehension; educational communication.

[1] Licenciada en Ciencias de la Educación: Mención Educación General Básica. Profesora Titular Escuela de Educación General Básica Gran Colombia. Estudiante del Programa de Maestría de Investigación en Educación. Mención Comunicación Educativa del Instituto de Posgrado de la Universidad Técnica de Manabí, Ecuador.
[2] Doctor en Ciencias Pedagógicas. Profesor Titular Universidad Técnica de Manabí, Ecuador. E-mail: robertson.calle@utm.edu.ec
Gender differences in the structure of the cerebrospinal fluid system of pre-school children
Authors: Baibakov S. E. , Bakhareva N. S. , Gordeeva E. K. , Yuzhakov M. V. , Khromov D. A. , Bakhareva A. A. 
Published: December 2021

Relevance Investigation of the cerebrospinal fluid system of children of different ages, especially pre-school and school periods of childhood, becomes essential, since the further development of the brain and its proper functioning depends on the way it functions. Considering the MRI indications of the elements of the cerebrospinal fluid system of children is important for the development of neurology and neurosurgery, it is necessary to consider gender differences in the brain size and structure.Objective To study the sex differences in the structure of the cerebrospinal fluid system in seven-year-old children.Material and Methods For the study, archival data on the sizes of the lateral ventricles of the brain of 120 children aged 7 (60 boys and 60 girls) were involved, in particular: 1) the length of the anterior horn; 2) the width of the anterior horn; 3) the length of the central part; 4) the width of the central part; 5) the length of the posterior horn; 6) the width of the posterior horn; 7) the length of the lower horn; 8) the anteroposterior size; 9) the distance between the anterior horns; 10) the distance between the posterior horns; 11) the length of the third ventricle; 12) the height of the third ventricle; 13) the length of the aqueduct; 14) the length of the fourth ventricle; 15) the height of the fourth ventricle. The studies were carried out using the method of magnetic resonance imaging. Quantitative indicators were assessed for compliance with the normal distribution using the KolmogorovSmirnov test. The accumulation, correction, systematization of the initial information were carried out in Microsoft Excel 2016. Statistical analysis was carried out using the Statistica 10.0 software (StatSoft Inc., USA). The results were considered statistically significant at p < 0.05.Results The data obtained in the study of the cerebrospinal fluid system in children during their pre-school period of childhood are indicators of the norm and can be used for diagnostic studies in the departments of radiation diagnostics. The bilateral asymmetry of the lateral ventricles of the brain in pre-school children, discovered during the work, is of crucial clinical significance. The morphometric indicators of the elements of the cerebrospinal fluid system should be considered by specialists in the study of brain neuroplasticity.Conclusion Analysis of the obtained in vivo encephalometric data indicates the presence of sexual variability of the brain and parameters of the structures of the cerebrospinal fluid.
Detection of symptom-related coronary arteries in patients with coronary artery disease using real-time three-dimensional stress echocardiography with adenosine triphosphate
Authors: Nelasov N. J. , Pomortsev A. V. , Arzumanjan E. A. , Eroshenko O. L. , Morgunov M. N. , Nechaeva A. G. , Martynova T. S. , Kreneva E. L. , Tanova A. A. 
Published: December 2021

Aim 1) To develop normative values of global and regional left ventricular longitudinal deformation (LVLD) during real time three-dimensional stress echocardiography with adenosine triphosphate (ATP) and utilization of automated function imaging technology (4D Stress-Echo + LVLD with ATP); 2) to compare the effectiveness of detection of symptom-related coronary arteries during 4D Stress-Echo with ATP using: a) traditional visual assessment of regional myocardial contractility and b) step-by-step analysis of segmental LVLD.Material and Methods 15 healthy subjects and 32 patients with coronary artery disease (CAD) were examined after coronary angiography. All individuals underwent 4D Stress-Echo + LVLD with ATP (Vivid E95, General Electric).Results The normative values of global LVLD at three stages of the pharmacological stress-test (before, during and after ATP infusion) were –19.5 (95% CI: -20.4 – -19.0), –21.6 (95% CI: -22.8 – -20.4) and –19.5 (95% CI: -20.3 – -18.6), respectively; the values of LVLD in each of the 17 segments of left ventricular myocardium in healthy subjects were also determined. In patients with CAD visual control of contractility during stress test revealed dynamic decrease in local thickening of the myocardium, appearance of new zones of contractility disorders and expansion of previously noted in 31.2% of cases, while analysis of deformation detected the appearance of new zones of deformation disturbances and expansion of previously found – in 68.7% (р = 0.0055). Stress-induced worsening of myocardial deformation during ATP infusion in the zones of blood supply of left anterior descending coronary artery, circumflex artery and right coronary artery (with presence of hemodynamically significant stenoses and occlusions detected during coronary angiography) were found in 28.0, 77.7 and 65.2% respectively (р1-3 = 0.0194; р1-2 = 0.0019; р2-3 = 0.2864).Conclusion The normal values of global and segmental LVLD for each stage of 4D Stress-Echo + LVLD with ATP were determined. 4D Stress-Echo + LVLD with ATP can significantly increase the effectiveness of symptom-related coronary arteries identification in patients with CAD in comparison with traditional Stress-Echo with visual assessment of local myocardial contractility.
Comparative analysis of local stimulation methods of reparative osteogenesis
Authors: Mukhanov M. L. , Blazhenko A. N. , Bogdanov S. B. , Sotnichenko A. S. , Rusinova T. V. , Verevkin A. A. , Aliev R. R. , Zaremuk A. M. , Porhanov V. A. 
Published: December 2021

Objective To determine the ratio of the main growth factors when using various methods of local stimulation of reparative osteogenesis.Material and methods The study consisted of two parts: in the first part a comparative analysis of the content of growth factors by ELISA was carried out (PDGF – platelet derived growth factor, TGF – transforming growth factor, VEGF – vascular endothelial growth factor, IGF – insulin-like growth factor, BMP6 and BMP7 – morphogenetic proteins 6 and 7), capable of stimulating reparative osteogenesis in blood plasma, plateletrich plasma, red bone marrow and bone autoregenerate. The second part presented the results of approbation of the autoregenerate obtained according to the original method in the framework of an acute experiment on animals.Results The most important cytokines affecting the process of reparative osteogenesis are fibroblast growth factor – FGF1 and bone morphogenetic protein 7 – BMP7. Based on the results of a comparative enzymelinked immunosorbent assay, it has been established that the autoregenerate, obtained by the original method, and a bone marrow aspirate concentrate have the highest osteogenic potential.Conclusion Autoregenerate is an effective and promising means of local stimulation of reparative osteogenesis, and its transplantation is a simple and highly effective procedure.
Biomarkers of heart failure: current state of problem
Authors: Ishevskaia O. P. , Namitokov A. M. , Kosmacheva E. D. 
Published: December 2021

There is constant increase in patients with heart failure every year worldwide. Early diagnosis and prediction of deterioration could upgrade management of patients and slow down the progression of heart failure.The brain natriuretic peptide precursor (NT-proBNP) is considered to be the universal biomarker, although it has several limitations. The search of ideal biomarker is directed into molecular biology and genetics. Microribonucleic acids (microRNAs) regulate different processes in human body, present myocardial specificity, and plasma stability. It has been proven in different trials that diagnostic and prognostic level of microRNAs is equal to NT-proBNP. Potential opportunities of the method are not only diagnosis but therapeutic targets for heart failure