bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodology for Automated Monitoring of Induced Vibrations in Tailings Dams Built Upstream
Authors: De Sousa Gustavo Marçal , Ferreira Sérgio Augusto , Gomes Romero César 
Published: February 2021

Abstract
Induced vibrations in tailings dams in Brazil became subject to studies after two major accidents in upstream-built structures. These ground vibrations may be responsible for liquefaction triggers and that motivated the development of this paper, which consists in the presentation of a methodology to perform homogeneous vibration monitoring tests along the entire embankment with an initial offline stage that later progressed to an automated process that represents the core object of the paper. Data collected from the initial monitoring enabled analyses of dam stability when correlating vibration levels in the embankment. As a consequence of such analyses, it was possible to parameterize control levels associated to safety criteria. Monitoring methodology, analysis techniques and gains resulting from the use of automated monitoring systems are presented herein. Parameterized control levels regarding the structure under study as well as their association to the stability condition, analysis of liquefaction trigger set for vibration values, advanced analysis of seismographic records and an automated operational vibration control system from monitoring using seismographic stations are shown. The implementation of the automated monitoring system associated to safety control levels allowed a robust diagnosis of eventual structural damages caused by vibrations in dams. That methodology was applied to a dam in operation and permitted evaluation of operation continuity concerning industrial plants and different operations with earthworks equipment on the embankment and its surrounding area.
Is the impact of high reward sensitivity and poor cognitive control on adolescent risk-taking more visible in rewarding conditions?
Authors: Fryt Joanna , Smoleń Tomasz , Czernecka Karolina , Szczygieł Monika , Torre Amelia La 
Published: February 2021

Abstract
Adolescents are expected to take more risks than adults. The presented study was designed to determine whether adolescent risk-taking results from high reward sensitivity and poor cognitive control. In particular, we aimed to examine whether the impact of these variables is more visible in rewarding than non-rewarding conditions. Ninety adolescents (aged 13–16) and 95 young adults (aged 20–28) took part in the study. We used a driving task in rewarded and non-rewarded conditions to measure risk-taking. We also used tasks measuring reward sensitivity, cognitive control and impulsivity. Additionally we used self-report measures of reward sensitivity, self-control and everyday risk-taking to see whether the effects observed for self-reports mimic the effects observed for behavioral tasks. We found that the higher the reward sensitivity, the more adolescents (but not adults) risk in the rewarded condition of a driving task. We found no impact of cognitive control or impulsivity on risk-taking, regardless of age and condition. At the self-report level, we found that the higher the reward sensitivity and the poorer the self-control, the more both adolescents and adults displayed everyday risk-taking behavior.
Melatonin Protects Cardiomyocytes from Oxygen Glucose Deprivation And Reperfusion-Induced Injury by Inhibiting Rac1/JNK/Foxo3a/Bim Signaling Pathway
Authors: Wang Yulin , Jian Ying , Zhang Xiaofu , Ni Bin , Wang Mingwei , Pan Chunqi 
Published: February 2021

Abstract
Melatonin has been shown to exert protective effect during myocardial ischemia/reperfusion (I/R). However, the underlying mechanism is not completely understood. Using the oxygen-glucose deprivation and reperfusion (OGD/R) model of H9c2 cells in vitro, we found that melatonin alleviated OGD/R-induced H9c2 cell injury via inhibiting Foxo3a/Bim signaling pathway. Inhibition of Rac1 activation contributed to the protective effect of melatonin against OGD/R injury in H9c2 cells. Additionally, melatonin inhibited OGD/R-activated Foxo3a/Bim signaling pathway through inactivation of Rac1. Furthermore, JNK inactivation was responsible for Rac1 inhibition-mediated inactivation of Foxo3a/Bim signaling pathway and decreased cell injury in melatonin-treated H9c2 cells. Taken together, these findings identified a Rac1/JNK/Foxo3a/Bim signaling pathway in melatonin-induced protective effect against OGD/R injury in H9c2 cells. This study provided a novel insight into the protective mechanism of melatonin against myocardial I/R injury.
Analysis of Reversible Switching Capacitive DAC Based Low Power SAR-ADC
Authors: G Prathiba , M Shanthi 
Published: February 2021

Abstract
This paper presents an analysis of Reversible Switching Capacitive Digital to Analog converter (RSC-DAC) based low power Successive Approximation Register Analog to Digital Converter (SAR-ADC).The proposed structure involves, the QVDC (Quantum Voltage Differential Comparator) constructed using Simple Transconductance Amplifier (STA) technique , the RSC-DAC switching energy reduced by 93% contrast to the standard Charge Redistribution Switching Capacitive DAC (CRSC-DAC) method, and the Successive Approximation Register(SAR) control logic is designed with D-FF based shift register. The QVDC comparator allows very small voltage comparison, and consumes low power and area effective. The linearity parameters such as Integral Nonlinearity, Differential Nonlinearity and parasitic effect of the capacitor of the RSC-DAC is analyzed and improved by the new approach is named as Adaptive Random Code Generation (ARCG) Technique. The above overall design is implemented by TANNER-EDA tool in 250nm CMOS technology, consumes 1.74mW power at 60MS/s. The INL and DNL of the proposed structure is +0.18/-0.12 LSB and +0.11/-0.05 LSB respectively.
Sulforaphane Inhibits Self-renewal of Lung Cancer Stem Cells Through the Modulation of Sonic Hedgehog Signaling Pathway and Polyhomeotic Homolog3
Authors: Wang FanPing , Sun Yanwei , Huang Xiaoyu , Qiao Caijuan , Zhang Wenrui , Liu Peijun , Wang Mingyong 
Published: February 2021

Abstract
Sulforaphane (SFN), an active compound in cruciferous vegetables has been characterized for its antiproliferative capacity. We investigated the role and molecular mechanism through which SFN regulates proliferation and self-renewal of lung cancer stem cells (CSCs). CD133-positive lung cancer cells were isolated by MACs from lung cancer A549 and H460 cells. And then, the expression of CD133 was measured by flow cytometry assays (FACS). The ability of cell proliferation was assessed by MTT assays and tumorsphere formation assays. The mRNA expression of Sonic Hedgehog (Shh), Smoothened (Smo), Gli1 and Human Polyhomeotic Homolog 3 (PHC3) was measured by quantitative reverse transcription polymerase chain reaction (QPCR). And the protein expression of Shh, Smo, Gli1 and PHC3 was determined by western blotting. Shh was knocked down by siRNA to further study the role of Shh signaling pathways in lung CSCs. SFN inhibited the proliferation of lung cancer cells and lung CSCs simultaneously. Meanwhile, the mRNA and protein expressions of Shh, Smo, Gli1 and PHC3 were highly activated in A549 /CD133+ and H460 /CD133+ cells. Compared with siRNA-control group, Knock-down of Shh inhibited proliferation of A549/ CD133+ and H460/ CD133+ cells, and decreased the protein expression of PHC3 in A549/ CD133+ and H460/ CD133+ cells. In addition, SFN inhibited the activities of Shh, Smo, Gli1 and PHC3 in A549/ CD133+ and H460/ CD133+ cells. Furthermore, the inhibitory effect of SFN on the proliferation of siRNA-shh cells is weaker than that of siRNA-control cells. SFN is an effective new drug which can inhibit proliferation of lung CSCs through the modulation of PHC3 and SHH signaling pathways. It provides a novel target for improving therapeutic efficacy for lung CSCs.
Hydatid Cysts of the Liver Rupture into the Peritoneal Cavity: Fifteen Cases and Review of the Literature
Authors: MEJRI Atef , ARFAOUI Khaoula , SAAD Sarra , RCHIDI Jasser , OMRI Ahmed , MSEDDI Mohamed Ali 
Published: February 2021

Abstract
BackgroundHydatid cyst is a parasitic infection caused mainly by E. Granulosus, which is generally considered benign. However, the hepatic Hydatid Cyst rupture in the abdominal cavity is a life-threatening incident that requires urgent and multidisciplinary management (emergency physician, radiologists, anesthetists, and surgeons). This study describes clinical and paraclinical liver hydatid cyst rupture in the peritoneal cavity and details the appropriate treatment.Materials and MethodsFifteen liver hydatid cyst cases ruptured into the abdominal cavity that underwent urgent surgery were collected over eight years. Results There were nine men and six women. Patients' age ranged from 14 to 59 years, with an age average of 38 years. Two patients were admitted with abdominal trauma, and acute abdominal pain was the common consultation's reason. Only one patient had an anaphylactic shock. Both abdominal ultrasound and CT scan showed discontinuous cyst wall and intraperitoneal fluid in 100% of cases. Intraoperatively, the intraperitoneal effusion was clear in thirteen cases and purulent in two. All patients underwent unroofing procedure associated with intra-operative peritoneal lavage and external drainage. The mean hospital stay was 6.11 days, and the mean follow-up was 19 months. No case of recurrence was reported among the patients.ConclusionRupture of a hydatid cyst in the abdominal cavity should be evoked in front of acute abdominal pain, especially in endemic areas, and in the presence of an allergic reaction or anaphylactic shock signs. Combined surgical and medical care starting in the emergency room is the only guarantee of a good outcome.
Developing Research Competence of Teachers as a Way of Increasing Competitiveness of HEIs in Kazakhstan
Authors: Begunova Mariya , Qingyu Xu 
Published: February 2021

Abstract
The present article shows the findings of a basic quantitative research of the teachers’ research competence and its influence on higher educational institutions’ (hereafter: HEI) competitiveness on the sample of Kazakh University of International Relations &World Languages after Ablaikhan (hereafter: KazUIR&WL). Using the method of questionnaire, the study investigates the level of satisfaction of the students and parents with the education quality in KazUIR&WL, their needs and expectations, as well as shows the linkage between teachers’ research competence and the quality of education. The research involves 19 teachers, 70 students and 70 parents, who present their opinions by answering both open-ended and close-ended questions. The present research is inductive non-experimental and helps build a strong theoretical platform for generating further research questions. The main purpose of the research is mostly an assessment of the current situation in teaching English in Kazakhstan, with elements of evaluation and description. In this aspect, the current study can become a good scientific background for generating further research ideas in the sphere of education, linguistics, methodology, history, foreign culture studies and others. The method used in the present research is the method of questioning.
Time-Domain Correlation Quantitative Analysis Method of Regional Rainfall-Landslide Displacement Responses Based on a Time-Domain Correlation Model
Authors: Wu Tingchen , Xie Xiao , Zhu Qing , Zhang YeTing , Wu Haoyu , Zeng Haowei 
Published: February 2021

Abstract
Landslide deformation is the most intuitive and effective characterization of the evolution of landslides and reveals their inherent risk. Considering the inadequacy of existing deformation monitoring data in the early warning of landslide hazards, resulting in insufficient disaster response times, this paper proposes a time-domain correlation model. Based on a regional rainfall-landslide deformation response analysis method, a time-domain correlation measure between regional rainfall and landslide deformation and a calculation method based on impulse response functions are proposed for prevalent rainfall-induced landslide areas, and the correlation with the rainfall-triggered landslide deformation mechanism is quantitatively modeled. Furthermore, using rainfall monitoring data to optimize the indicator system for landslide deformation monitoring and early warning significantly improves the preliminary warning based on landslide deformation. The feasibility of the method proposed in this paper is verified by analyzing the historical monitoring data of rainfall and landslide deformation at 15 typical locations in 5 landslide hidden hazard areas in Fengjie County, Chongqing city. (1) The correlation models for the XP landslide and XSP landslide involve a 5-day lagged correlation under a 56-day cycle and a 18-21-day lagged correlation under a 49-52-day cycle, which means that the deformation in the above areas can be modeled cyclically according to monitoring data, and early landslide warnings can be provided in advance with a lag time. (2) The correlation models for the TMS landslide and OT landslide show consistent correlations under a 48-50-day cycle and a 58-day cycle, which means that the deformation in the above areas can be predicted based on rainfall accumulation, and real-time warnings of future landslide deformation and displacement can be obtained. (3) The HJWC landslide presents a disorderly correlation pattern, which means that a preliminary landslide deformation warning cannot be provided based on rainfall alone; other monitoring data need to be supplemented and analyzed.
Expression and Gene Regulation Network of SOX9 in Skin Metastasis of Gastric Carcinoma Derived From One Special Patient
Authors: Chen Guofeng , Zhu Jiyun , Yang Tang , Wang Huifang , Zhu Liegang , Yan Zhilong , Zhang Moucheng 
Published: February 2021

Abstract
BackgroundAn exceptional case of a patient with advanced gastric cancer is presented in this study, treated with multiple chemotherapy, radiotherapy and immune regimens, who exhibited regression of one metastatic lesion with concomitant progression of the other lesion during a treatment of PD-1 antibody period. MethodsUsing whole-exome sequencing, TBM, MSI/MSS, PD-1 positive or negative respond measurement, gene function, tumor expression, clinical stage, survival curve, pathopoiesia gene prediction, neoantigen score and immunogenomic approaches. ResultsWe found that SOX9 might mainly participate into the response process of PD-1 antibody in the right skin metastasis. Then, we used sequencing data from the Cancer Genome Atlas database and Gene Expression Omnibus, analyzing SOX9 expression and gene regulation networks in gastric carcinoma (GC). Expression and CNVs were analyzed using Oncomine and Gene Expression Profiling Interactive Analysis tools, at the same time, SOX9 alterations and related pathway were identified using cBioPortal. LinkedOmics and GeneMANIA were used to identify differential mRNA expression with SOX9 and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Gene enrichment analysis examined target networks of kinases, miRNAs, transcription factors and PPIs. The results show that SOX9 is overexpressed and the alteration type of SXO9 is mutation in GC. Expression of this gene coding protein is associated with biological interaction networks involving the cell dedifferentiation and WNT signaling process. Functional network analysis indicates that SOX9 mRNA level regulates the RNA process, DNA replication and cell cycle via pathways involving several cancer-related kinases, miRNAs and transcription factors, like casein kinase 2 alpha 1, cyclin dependent kinase 2, Mir296 and Mir214. ConclusionsOur results finally demonstrate that bioinformation analysis efficiently reveals online information of SOX9 expression and potential regulatory networks in GC, laying a foresight for further study of the role of SOX9 and a new PD-1 treatment predictor in gastric carcinogenesis.
Research on micro milling mechanism and surface roughness of high volume fraction SiCp/Al composites
Authors: Jin Po , Gao Qi , Wang Quanzhao , Li Wenbo 
Published: February 2021

Abstract
In this paper, the finite element simulation model of diamond tool milling SiCp/Al composites was established.The milling force, stress distribution and removal mechanism of SiC reinforced granular material were studied. The correctness of finite element simulation is verified by micro milling experiments. The results show that the maximum stress mainly occurs when the SiC particles are milled with PCD tool. The removal mechanism of particles is different when the tool is milling particles at different positions. The material surface defects are reduced and the surface quality is improved as the cutting speed is increased. The surface defects of SiCp/Al milling with single edge diamond milling tool mainly include cavities, microcracks, scratches and pits. According to the measurement results, it can be founded that the milling depth has the greatest influence on the surface roughness, followed by the spindle speed and the feed speed.
High Expression of eIF4E Regulates Immune Cell Infiltration and Leads to Poor Prognosis in Breast Cancer
Authors: Li Fan , Sun Huizhi , Li Yue , Bai Xiaoyu , Dong Xueyi , Zhao Nan , Meng Jie , Sun Baocun , Zhang DanFang 
Published: February 2021

Abstract
Background: The expression and activation of Eukaryotic translation initiation factor 4E (eIF4E) is related to tumor transformation and genesis, but the functional role and the mechanism whereby it drives immune infiltration in breast cancer remain uncertain.Methods: Multiple databases were used for assessing the expression and clinic-pathological features of eIF4E, after which ImmuCellAI and TIMER database were used to explore the relationship between eIF4E and immune infiltration of breast cancer. Finally, the genes co-expressed with eIF4E were identified by LinkedOmics. These genes were analyzed protein interaction network and TF-miRNA interaction network by Networkanalyst, and enriched by GO and KEGG. The key genes of immune markers were functionally annotated.Results: High expression of eIF4E was associated with poor overall survival (OS) and relapse-free survival (RFS) in breast cancer samples from multiple databases. It is notable that the expression of eIF4E is positively correlated with the infiltration of CD8+T cells, macrophages, neutrophils and dendritic cells. The expression of eIF4E is closely related to many immune markers in breast cancer. Functional analysis of co-expressed genes showed that they were involved in the biological process of human immune response. GO analysis showed that co-expressed immune marker genes were involved in human immune response, adaptive immune response, macrophage activation, extracellular structure organization and regulation of DNA metabolism process. KEGG enrichment showed that it was involved in inflammatory bowel disease, cell adhesion molecule pathway, JAK-STAT signal pathway, T cell receptor signal pathway and so on.Conclusions: These results suggest that high expression of eIF4E regulates immune cell infiltration, especially promotes macrophage M2 polarization by JAK / STAT6 and PI3K / AKT pathway, which is associated with poor prognosis of breast cancer patients. It is a valuable prognostic biomarker for breast cancer patients, and may be a potential therapeutic target in the future.
Lcsain3, A Novel Gene From Sheepgrass, Regulates Arabidopsis Seed Germination And Seedling Growth Under Salt Stress
Authors: Li Xiaoxia , Yang Weiguang , Li Qian , Zhao Pincang , Jia Junting , Qi Dongmei , Chen Shuangyan , Cheng Liqin , Liu Gongshe 
Published: February 2021

Abstract
Sheepgrass is a perennial native grass species with an aggressive and vigorous rhizome system, and it can tolerate high levels of salt stress. Many salt stress-responsive genes have been identified in sheepgrass. Here, we identified and characterized a novel salt-induced gene, LcSAIN3 (Leymus chinensis salt-induced 3), from sheepgrass. Expression analysis confirmed that LcSAIN3 is induced by PEG, ABA and salt stress. Subcellular localization analysis indicated that the LcSAIN3 protein is mainly localized in the chloroplasts. The heterologous of LcSAIN3 in Arabidopsis increases seed germination under various stress conditions. More importantly, the seedling survival, plant height and weight of the transgenic plants are higher than those of the WT plants under salt stress. The overexpression of LcSAIN3 causes a relatively high accumulation of free proline; enhances SOD activity; and leads to the upregulated expression of several stress-responsive genes, such as AtRAB26, AtRD29B, AtSOS1 and AtP5CS1. Our results suggest that LcSAIN3 may be a useful gene for the molecular breeding to improve plants salt stress tolerance.
Efficacy and Radiographic Analysis of Posterior Mono Axial Pedicle Screw Fixation in Treating Thoracolumbar Burst Fractures
Authors: Lee Sang-Soo , Shim Jae-Hoon , Seo Eun-Min 
Published: February 2021

Abstract
Objective: The purpose of this study was to evaluate the effectiveness of posterior mono axial pedicle screws fixation in the treatment of thoracolumbar burst fractures.Methods: In the present study we analyzed 50 patients retrospectively who had thoracolumbar burst fractures without a neurological deficit. Patients were divided into 2 groups: mono axial pedicle Screw fixation group (n = 25) and poly axial pedicle Screw fixation group (n = 25). We collected clinical data (visual analog scale score for back pain) and included radiographic measurements. The latter were used to calculate the sagittal plane kyphosis.Results: For the mono group, the preoperative mean sagittal index (SI) was O.59 ± 0.12 (range, 0.37–0.77), and the last follow up sagittal index (SI)was O.76 ± 0.09 (range, 0.56–0.89). For the poly group, the preoperative sagittal index (SI) was O.57 ± 0.11 (range, 0.34–0.82),and the last follow up sagittal index (SI) was O.65 ± 0.11 (range, 0.36–0.87). For the mono group, the mean postoperative regional kyphosis correction rate was 62.31%, and correction loss was 14.18% in late follow-up. For the poly group, the mean postoperative regional kyphosis correction rate was 52.17%, and correction loss was 33.42% in late follow-up. The mono axial pedicle screw group had good correction rate, and reduce the risks of correction loss. The mean visual analog scale (VAS) scores for back pain improved by 2.4/2.5 and 3.8/4.2 for the mono and poly groups. There was no significant difference between groups.Conclusions: The mono axial pedicle screw fixation was better for reducing and maintaining anterior vertebral height and regional kyphosis. Therefore, the mono axial pedicle screw is a better optional instrumentation to treat thoracolumbar vertebral fractures.