bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against S. pneumoniae Infection
Authors: Bhalla Manmeet , Nayerhoda Roozbeh , Tchalla Essi Y. I. , Abamonte Alexsandra , Park Dongwon , Simmons Shaunna R. , Pfeifer Blaine A. , Bou Ghanem Elsa N. 
Published: December 2021

Despite the availability of licensed vaccines, pneumococcal disease caused by the bacteria Streptococcus pneumoniae (pneumococcus), remains a serious infectious disease threat globally. Disease manifestations include pneumonia, bacteremia, and meningitis, resulting in over a million deaths annually. Pneumococcal disease disproportionally impacts older adults aged ≥65 years. Interventions are complicated through a combination of complex disease progression and 100 different bacterial capsular polysaccharide serotypes. This has made it challenging to develop a broad vaccine against S. pneumoniae, with current options utilizing capsular polysaccharides as the primary antigenic content. However, current vaccines are substantially less effective in protecting the elderly. We previously developed a Liposomal Encapsulation of Polysaccharides (LEPS) vaccine platform, designed around limitations of current pneumococcal vaccines, that allowed the non-covalent coupling of polysaccharide and protein antigen content and protected young hosts against pneumococcal infection in murine models. In this study, we modified the formulation to make it more economical and tested the novel LEPS vaccine in aged hosts. We found that in young mice (2–3 months), LEPS elicited comparable responses to the pneumococcal conjugate vaccine Prevnar-13. Further, LEPS immunization of old mice (18–22 months) induced comparable antibody levels and improved antibody function compared to Prevnar-13. Importantly, LEPS protected old mice against both invasive and lung localized pneumococcal infections. In summary, LEPS is an alternative and effective vaccine strategy that protects aged hosts against different manifestations of pneumococcal disease.
Physiological and Biochemical Characterization of Isolated Bacteria from a Coccolithophore Chrysotila dentata (Prymnesiophyceae) Culture
Authors: Wang Xueru , Liu Yang , Sun Jun 
Published: December 2021

Coccolithophores are involved in oceanic carbon and nitrogen cycles, and they also have an impact on global climate change. Chrysotila dentata have a complex and close relationship with phycosphere bacteria. In this study, culturable phycosphere bacteria (free-living bacteria and attached bacteria) are isolated from C. dentata by a gradient dilution method and identified based on the 16S rRNA gene sequencing analysis. The phylogenetic tree (neighbor-joining tree, N-J tree) was constructed using the bacterial sequences and closest related sequences from GenBank. Colony characteristics, Gram nature, and physiological and biochemical characteristics were obtained based on a series of tests, such as the sugar utilization (glucose, arabinose, xylose, maltose, and mannitol) test, Voges–Proskauer reaction, urease tests, gelatin liquefaction, Gram test, starch hydrolysis, among others. In this study, seven strains (CF1, CF2, CF3, CF5, CF6, and CF7) of free-living bacteria (CF) and five strains (CA1, CA2, CA3, CA4, and CA5) of attached bacteria (CA) are isolated and identified. We found that the culturable phycosphere bacteria of C. dentata were mainly α-proteobacteria and γ-proteobacteria, with a small part of the CFB (Cytophaga-Flexibacter-Bacteroides) group bacteria and firmicutes. In this study, most α-proteobacteria can utilize malonate and positive in the urease test, meanwhile they can grow in a 7% NaCl medium. Differently to α-proteobacteria, γ-proteobacteria are more reactive, and can utilize maltose, glucose, arabinose, malonate, aesculin, and starch hydrolysis. Meanwhile, γ-proteobacteria can growth in a 7% NaCl and pH 5.7 medium, and some bacteria of this strain were positive in nitrate reduction. Firmicutes are similar to γ-proteobacteria: they are similar in reactivity, as they can utilize maltose, glucose, arabinose, malonate, aesculin, and starch hydrolysis, and can growth in a 7% NaCl and pH 5.7 medium. The difference is that some of firmicutes were positive in gelatin liquefaction and can utilize mannitol. The CFB group of bacteria were only positive in malonate, aesculin, and starch hydrolysis. The above results provide basic experimental data for further studies on the relationship between the coccolithophores and culturable phycosphere bacteria.
Reorganización logística y espacial de las cadenas de suministro marítimo-portuarias en México: entre el neoproteccionismo comercial y la pandemia del COVID-19
Authors: Martner Peyrelongue Carlos Daniel 
Published: December 2021

En los últimos años, las cadenas de suministro marítimo-portuarias movilizadas a través de redes globales de transporte intermodal han enfrentado escenarios adversos derivados tanto de las tensiones geopolíticas expresadas en el neoproteccionismo y la guerra comercial entre las principales potencias mundiales, como en la aparición fulminante y demoledora de la pandemia del COVID-19.
En este contexto, han quedado evidenciadas ciertas vulnerabilidades de la fragmentación logística y espacial de los procesos productivos derivados de la globalización económica que ha primado en las últimas tres décadas. La guerra comercial entre países centrales de la economía-mundo, pero sobretodo la irrupción de la pandemia del COVID-19 provocaron desajustes enormes que interrumpieron de manera abrupta la regularidad y continuidad del suministro de insumos y bienes de las cadenas productivas extensas que se articulan mayoritariamente en un espacio global a través de complejas redes de transporte marítimo e intermodal.
Derivado de lo anterior, la presente propuesta busca avanzar en la identificación de los impactos logísticos y espaciales del COVID-19 en el transporte marítimo de mercancías y en los puertos mexicanos, así como visualizar, a grandes rasgos, las tendencias emergentes de articulación espacial de las cadenas de suministro globalizadas, con la finalidad de aportar elementos cualitativos que eventualmente contribuyan o coadyuven a la construcción de escenarios post-pandemia, a partir de un enfoque teórico-metodológico de tipo estructural-sistémico, basado en la conformación de un espacio de redes y flujos globales.
La movilidad post pandemia: perfiles y usos de la micromovilidad en Barcelona
Authors: Roig-Costa Oriol , Gómez-Varo Irene , Cubells Jerònia , Marquet Oriol 
Published: December 2021

La irrupción de la micromovilidad, como una alternativa sostenible e inclusiva a los modos motorizados convencionales, cobra especial importancia a raíz de la crisis del COVID-19. El objetivo del artículo es estudiar el perfil de los usuarios de estos medios de transporte y cómo la pandemia ha modificado sus desplazamientos, contribuyendo a la incipiente investigación en este ámbito. El estudio ofrece una aproximación a estas nuevas formas de movilidad en Barcelona, usando la primera encuesta realizada en la ciudad a personas usuarias de patinete eléctrico, bicicleta convencional y eléctrica compartidas, y motocicleta eléctrica compartida (n=902). El análisis presentado indica que los usuarios más habituales son hombres jóvenes y ocupados. Los motivos de desplazamiento son diversos, aunque varían en función del vehículo. Los resultados también apuntan que casi un tercio de los usuarios de micromovilidad modificó su modo de transporte habitual a raíz de la pandemia, especialmente los que antes se desplazaban en transporte público o a pie. Se cuestiona el potencial de la micromovilidad para reducir las emisiones y se apunta a las implicaciones en términos sociales, tanto por el uso diferenciado en función de las características sociodemográficas, como por el impacto en la salud y en el espacio público.
Hybrid Model Of Structural Equation Modeling Pls And Rfm (Recency, Frequency And Monetary) Model To Improve Bank Average Balance
Authors: Jerry Heikal  , Vitto Rialialie  , Rivelino Deva , Ign Agus Supriyono  
Published: December 2021

As a business players, entrepreneurs certainly need bank products and supports that provide fast and easy services with wide-spread network in Indonesia. In this study, Structural Equation Model (SEM) identify the transaction that influence the average balance. The objects of the RFM segmentation on the selected transaction is to understand customer segment score and build a marketing strategy for each segment with different levels of loyalty for the Financial result of higher Average Balance.
The segmentation results found three driver categories, High Recency, Mid Recency and Low Recency category. High Recency is considered Active customer where campaign category can be cross/up-selling and promotional accordingly with their Frequency and Monetary category. Mid Recency category is considered Risky customer where campaign category can be retention program accordingly with their Frequency and Monetary. Last, Low Recency is considered already Churn customer where campaign category is to conduct reactivation.
ROUTE SELECTION METHOD FOR HIGH-DENSITY WIRELESS IOT NETWORK
Authors: БУШЕЛЕНКОВ С.Н. , ПАРАМОНОВ А.И. 
Published: December 2021

Приводятся результаты исследования зависимости скорости передачи данных (ПД) от параметров маршрута в беспроводной сети интернета вещей. Предложен метод выбора количества и позиций узлов для организации маршрута в сети. Метод учитывает влияние расстояния между узлами маршрута и их количества на задержку доставки данных и скорость ПД по маршруту. Метод позволяет получить выигрыш в достижимой скорости ПД по сравнению с методами выбора маршрута по критерию количества транзитных узлов.
The article presents theresults ofthe studyof thedependence of the data transfer rate on the route parameters in wireless Internet of Things (loT) networks. A method for choosing the number and positions of nodes for organizing a route in the loT network is proposed. The method takes into account the influence of the distance between the nodes of the route and their number on the delay in data delivery and the speed of data transmission along the route. The method allows one to obtain a gain in the attainable data transfer rate in comparison with methods of choosing a route based on the criterion of the number of transit nodes.
A construção do discurso midiático quando o estupro entra em campo
Authors: Silva Conceicao Almeida da , Azeredo Anabel Medeiros 
Published: December 2021

As mídias definem-se como organismo especializado em preencher uma necessidade social de informação. No entanto, de acordo com Charaudeau (2010a) a informação é construída pela linguagem, que, inevitavelmente, produz uma visão do mundo, atribuindo-lhe um sentido particular. Portanto, ao informar, as mídias impõem ao seu destinatário a sua visão de mundo, constroem sistemas de valores e produzem sentidos. Para verificar como o discurso midiático constrói a realidade, serão analisadas manchetes de sites jornalísticos, produzidas a partir de discursos relatados que se referem a jogadores de futebol brasileiros envolvidos em casos de estupro. O modo de relatar o dito de outrem pode revelar o posicionamento do organismo de informação, que, na maioria das vezes, parece favorável aos jogadores de futebol acusados de crimes dessa natureza, reforçando o machismo e a cultura de estupro. Os pressupostos teóricos usados concentram-se nos postulados da Semiolinguística aplicados ao contrato de informação midiático.
Palavras-chave: Futebol; Estupro; Contrato de informação midiático; Discurso relatado.
USING OF TRIPLE-TREATED WASTEWATER IN AGRICULTURAL IRRIGATION IN AL-AHSA OASIS, SAUDI ARABIA.
Authors: El-Sebaei M. N. , Osman R. T. , Mansour H. E.H. , Al-Asmari M. A. 
Published: December 2021

The agricultural sector consumes about 84% of the total actual water consumption annually in Kingdom of Saudi Arabia, therefore, the research depends on questionnaire data that was judged before being used in the study of a random sample of 355 farms from Al-Ahsa Oasis which irrigated with two types of water (groundwater, triple-treated wastewater) to measure the economic impact of the using of triple-treated wastewater in irrigating palm and lemon crops, the results indicated a statistically significant correlation between the extent of farmers' which using of triple treated wastewater in irrigation and all of: size of the tenure, family size and the educational level of the farmer. While the relationship was negative with all of: age of the farmer, and number of years of his experience. The results showed that the productivity of dunums on farms irrigated with triple-treated wastewater increased by 0.32, 0.30, 0.22 tons, representing about 19.2%, 17.2%, 16.8% compared to which using groundwater for Alkhallas palm, Alrziz palm and lemon.
céu que cai sobre a Terra
Authors: Mizutani Luciana 
Published: December 2021

Resenha do áudio drama O céu que cai sobre a Terra, realizado pelo canal O bardo PODCAST, que é um recorte na vida de uma aldeia que está na fricção entre o mundo tradicional e o (in)civilizado. A tensão entre esses mundos se agrava quando pelas queimadas na floresta o dia vida noite. A narrativa acompanha a história de uma anciã e uma criança, revelando formas outras de imaginar mundos e criar sujetividades.
Bringing a Global Perspective to Students via Telesimulation
Authors: Peralta Heather , Diaz Desiree A , Diaz Ruben 
Published: December 2021

The aim of this Simulation Based Experience (SBE) was to replicate a global initiative via a telesimulated environment. Due to COVID-19, all study abroad trips were canceled by both the University and the governments of both the United States and Peru. In order to facilitate the learning goals and objectives, faculty developed a fully functional, online module via Zoom, which simulated in-country experiences. Three four-hour Zoom sessions allowed faculty to utilize INASCL standards of best practice to facilitate SBE activities such as pre and post-operative education for an Embedded Participant (EP) playing the role of patient (INACSL Standards Committee, 2016; Lioce et al., 2020). 80% of students attempted to speak Spanish over the course of the SBE. During the debrief process, students were asked to provide affective words regarding the SBE which indicated trepidation in utilizing the Spanish language and not understanding content. On the final day of simulation, all students found value and collaboration in the process. Telesimulation via Zoom allowed students to be immersed in an unknown culture, and the use of breakout rooms encouraged engagement with EP one-on-one. Zoom for remote simulation is a plausible replacement for HFPS due to the COVID-19 pandemic. Research is needed to explore and compare cultural gains and sensitivity to students in-country versus through remote learning.
MANAGEMENT OF APARTMENT BUILDINGS IN RUSSIA BEYOND BUDGETING
Authors: Литвинцев Денис Борисович , Нижальская Наталья Ивановна 
Published: December 2021

В статье рассматривается 12 принципов Beyond Budgeting, предложенные Дж. Хоупом и Р. Фрейзером, и особенности их применения к управлению многоквартирными домами. Анализируется возможность внедрения Beyond Budgeting не только в управляющих организациях, но и при непосредственном управлении многоквартирными домами и создании товариществ собственников жилья. Результаты внедрения принципов Beyond Budgeting (изменение организационной культуры) анализируются по модели McKinsey 7S. Рекомендации по внедрению Beyond Budgeting даются в рамках теории организационных изменений М. Бира и Н. Нориа. Положительный опыт внедрения принципов Beyond Budgeting в ООО УК «Маяк» позволяет рекомендовать управление за рамками бюджетирования другим организациям, осуществляющих предпринимательскую деятельность по управлению многоквартирными домами в России.
The article examines the 12 principles of Beyond Budgeting , proposed by J. Hope and R. Fraser, and the peculiarities of their application to the management of multi-apartment buildings. The possibility of introducing Beyond Budgeting is analyzed not only in management organizations, but also in the direct management of apartment buildings and in creation of a homeowners' association. The results of the implementation of the principles of Beyond Budgeting (change in organizational culture) are analyzed according to the McKinsey 7S model. Recommendations for the implementation of Beyond Budgeting are given in the framework of the theory of organizational change by M. Beer and N. Noria. The positive experience of implementing principles of Beyond Budgeting at OOO Management Company ‘Mayak’ allows us to recommend Beyond Budgeting management to other organizations carrying out entrepreneurial activities in the management of apartment buildings in Russia.
Factors Affecting Generalization of Ocular Myasthenia Gravis in Palembang
Authors: Farid Zahratul Riadho , Devi Azri Wahyuni  
Published: December 2021

Introduction. Ocular myasthenia gravis (OMG) is an autoimmune disease which is characterized by weakness of extraocular muscles, levator palpebrae and orbicularis oculi, resulting in ptosis and binocular diplopia. Nearly all patients present with eyelid and extra ocular muscles involvement. Approximately 30% to 80% of patients with OMG experience a conversion to generalized myasthenia gravis (GMG) within 2 years. There are not only have ptosis and diplopia but also limb weakness,bulbar symptoms, or even respiratory failure. This study was aimed to observe the clinical features of OMG to GMG and risk factors and median time to conversion of OMG to GMG of myasthenia gravis patients in Mohammad Hoesin General Hospital Palembang.
Method. This study is a cohort retrospective study and the data were collected from the medical records of 91 patients who were registered as myasthenia gravis patients during September 2018 to March 2020. Sosiodemographic and clinical characteristics, including onset of OMG to GMG, history of smoking, presence of thymic abnormalities, and medications received were reviewed retrospectively.
Result. A total of 91 OMG patients were observed in this study with 32 (35,2%) patients converted from ocular myastenia gravis to general myastenia gravis. Median conversion time to GMG was 34 months. Risk factor for convertion cases of OMG to MGG was receiving immunosupressive agents (Risk: 14.7, 95% CI 4.83, 44.7), thymus hyperplasia (Risk: 3.36, CI 95% 0.33, 33.6), Female (Risk: 2.41, 95% CI 0.94, 6.17), Smoking (Risk: 1.56, 95% CI 0.31, 7.81).
Conclusion. Ptosis was the definitive sign for OMG in this study, with all patients had ptosis, thus it needs the colaboration from neuroophthalmologist and neurologist to diagnose and manage this case. Most of converted case was female and those who receive an immunosupressive agent therapy.
THE CONCEPT OF A BUSINESS MODEL FOR AN AIR CARRIER IN SLOVAKIA
Authors: Baláž Radovan 
Published: December 2021

Determining the operating airline's business model is among the strategic decision, particularly for emerging airlines. A suitable and correct business model is an essential prerequisite for the company to establish itself in the market and be competitive successfully. This paper aims to design a specific business model for an air carrier, considered a national air carrier in Slovakia. Slovakia currently has no national air carrier, which would contribute to the development of passenger air transport and would reflect the domestic population's current needs and help increase inbound tourism. The main goal of the designed air carrier is to contribute to the development of air transport in Slovakia and transport a higher number of air passengers, reaching at least an average increments as in other European Union countries. This study proposes a business model framework applied to the conditions of Slovakia, which analyzes the main trends identified in the literature for designing business models for airlines abroad. In examining various studies, we have identified aspects of business models and the main models used by airlines abroad. We used general methods to process information and assess current trends in air transport. In the study, we apply the list method and the inventory method, focusing on new trends and process management methods in the aviation industry. Finally, we developed a business model for a potential air carrier operating in Slovakia from the acquired knowledge.
Methodological Pluralism of Legal Thinking: Problems of Theory and Philosophy of Law
Authors:   Lomonosov Moscow State University, Moscow, Russian Federation, Frolova Elizaveta A. 
Published: December 2021

Introduction. Currently, in theoretical and legal science, discussions continue about the un- derstanding of the content and the methodology of the knowledge of law. This article shows the theoretical approaches to the study of law in different historical periods. Law is analysed from the point of view of formal dogmatic jurisprudence, sociological direction in law, and the theory of natural law in both their historical and theoretical aspects. Theoretical Basis. Methods. The purpose of this work is to study the content of law as a sociocultural phenomenon. To achieve this, the following tasks are examined: the analy- sis of law as the most important social regulator of human activity is undertaken – which shows the right as a part of spiritual life. Further, the main legal schools and trends in law are analysed. In the course of the study, the following methods were used: analysis and synthesis, a her- meneutic, and a comparative approach. Results. As a result of the study, the author came to the following conclusions: 1)	the plurality of methodological approaches to the study of the nature and purpose of law are due to the dialogical nature of theoretical and legal sciences (philosophy of law, theory of state and law, history of political and legal doctrines, and the sociology of law); 2)	the basis of the methodological pluralism of legal thinking lies in the different content of law. This is where law is understood as an interest, as a freedom, as a social duty, as a morality, as an order of the authorities, as the discretion of a judge, as well as the degree of implementation of the legal phenomenon in the concrete historical conditions of society; 3)	each doctrine of law and the state is a model for solving the legal issues of its time. This includes proposing and arguing for one or another option for maintaining public order. It is original and can (and should) be applied in specific socio-political conditions. Discussion and Conclusion. Each doctrine of law and the state is a model for solving legal issues of its time. Offering various options for resolving urgent political and legal issues, these theories can (and do) enter into conflicts with each other. Each of the legal concepts, offering and arguing for one or another option for maintaining public order, is original and can (and should) be used in specific socio-political conditions. At the doctrinal level, political and legal concepts are variants of alternative legal thinking, the validity and relevance of which is confirmed by the degree of demand at a particular historical stage of the develop- ment of society, law, and the state.