bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfluthrin Eave-Positioned Targeted Insecticide (EPTI) Reduces Human Landing Rate of Pyrethroid Resistant and Susceptible Malaria Vectors in a Semi-Field Simulated Peridomestic Space
Authors: Tambwe Mgeni , Moore Sarah J , Hofer Lorenz , Kibondo Ummi Abdul , Saddler Adam 
Published: March 2021

Abstract
Introduction: Volatile pyrethroids (VPs) are proven to reduce human–vector contact for mosquito vectors. With increasing resistance to pyrethroids in mosquitoes, the efficacy of VPs such as transfluthrin may be compromised. Therefore, experiments were conducted to determine if the efficacy of transfluthrin eave-positioned targeted insecticide (EPTI) depends on the resistance status of malaria vectors.Methods: Ribbons treated with 5.25 g transfluthrin or untreated controls were used around the eaves of an experimental hut as EPTI inside a semi-field system. Mosquito strains with different levels of pyrethroid resistance were released simultaneously, recaptured by means of human landing catches (HLCs) conducted 2.5 m outside the hut, and monitored for 24-hour mortality. Technical-grade (TG) transfluthrin was used, followed by emulsifiable concentrate (EC) transfluthrin and additional mosquito strains. Generalised linear mixed models with binomial distribution were used to determine the impact of transfluthrin and mosquito strain on mosquito landing rates and 24-hour mortality. Results: A significant interaction between strain and treatment indicated that the effect of the transfluthrin EPTI varied between three strains under investigation (P < 0.001). Whether TG or EC, EPTI significantly reduced the odds of landing of pyrethroid-susceptible mosquitoes Anopheles gambiae (Ifakara) and An. gambiae (Kisumu) and of pyrethroid-resistant mosquitoes An. arabiensis (Mbita), An. gambiae Kisumu knockdown-resistant (Kisumu-kdr) and An. arabiensis (Kingani), with PE > 40% for all strains (P < 0.001). In the control, An. gambiae mosquitoes were more likely to land than An. arabiensis (P < 0.05). Conclusions: This study confirms that the efficacy of EPTI was not dependent on mosquito pyrethroid resistance status. However, it remains unclear whether resistance to pyrethroids undermines the efficacy of transfluthrin for bite prevention. It is important to consider mosquito anthropophagy, strain, years of colonisation and fitness when assessing vector control interventions. Overall, these findings suggest that transfluthrin-treated EPTI could be useful in areas with highly pyrethroid-resistant mosquitoes. At this dosage, transfluthrin EPTI cannot be used to kill exposed mosquitoes.
Perceived and Actual Risks of Drought : Household and Expert Views From Lower Teesta River Basin of Northern Bangladesh
Authors: Salam Roquia , Ghose Bonosri , Shill Badhon Kumar , Islam Md. Aminul , Islam A R M Towfiqul , Sattar Md. Abdus , Alam G M Monirul , Ahmed Bayes 
Published: March 2021

Abstract
Disaster risk perception, as well as risk appraisal, play a pivotal role in making the disaster risk reduction policy. This study examines the actual vs perceived drought risks by constructing risk indices at the household and expert levels using survey data from the lower Teesta River Basin in northern Bangladesh. Survey data were collected from 450 farmers based on the structural questionnaire. A composite drought risk index was developed to understand households’ perceived and actual risks in the designated areas. The results show that the actual and perceived risk values differ significantly among the three designated sites of Ganai, Ismail, and Par Sekh Sundar. The risk levels also differ significantly across the household’s gender, income, occupation, and educational attainment. People with poor socio-economic status are more prone to drought risk than others. Results also reveal that the mean level of perceived risk agrees well with the actual risk; females perceive comparatively higher risk than males. Expert views on drought risk are similar to the individual household level perceived risk. The outcomes of this study would help the policy-makers and disaster managers to understand the concrete risk scenarios of the study areas and to take timely and appropriate disaster risk reduction actions for ensuring a drought-resistant society.
Prevalence of Bacterial Infections and the use of Multiplex Pcr Assay for Rapid Detection in Cultured Fish in Ghana.
Authors: Diyie Rhoda Lims , Aheto Dennis W. , Osei-Atweneboana Mike Y. , Armah Emmanuel , Yankson Kobina 
Published: March 2021

Abstract
The modern and rapid avenue for detecting pathogens provided by molecular genetic techniques including polymerase chain reaction (PCR) was explored in the present study to identify prevalent disease pathogens, from six aquaculture farms and in two commonly cultured fish in Ghana. The specific detection was carried out directly on clinical samples of naturally infected fish (O. niloticus and C. gariepinus) based on syber-mix reaction protocol in traditional PCR. Molecular diagnostic techniques allowed the detection of six most common and important bacteria pathogens in aquaculture farms in Ghana. Also, three of the pathogens (Streptococcus agalactiae, Streptococcus iniae and Staphylococcus aureus) were simultaneously isolated in a multiplex reaction. The results indicated 90% - 100% sensitivity and specificity for each of the six bacterial pathogens tested. Streptococcosis and motile aeromonad septicemia were found to be highly prevalent in most aquaculture farms in Ghana with severity in infections traced to the 85.7% and 14.9% co-infections with all six target pathogens in catfish and tilapia respectively. Prevalence rate of infections significantly correlated with variations in salinity, conductivity and dissolved oxygen concentrations in the thermal stressed condition of the culture water.
Dynamic Response Characteristics of a Toppling Rock Slope Under Seismic Excitation using Time-frequency Joint Analysis Method: A Case Study from the Southwest of Sichuan Basin, China
Authors: Song Danqing , chen zhuo , Dong Lihu , Du Han 
Published: March 2021

Abstract
The two-dimensional dynamic analysis was used to study the dynamic response characteristics of a toppling rock slope based on the time-frequency joint analysis method using the FLAC (Fast Lagrangian Analysis of Continua). Two-dimensional dynamic analyses were carried out on two numerical models. The results of the numerical dynamic analyses show that the toppling slope has an topographic and geological dynamic amplification effect. There are an elevation and surface dynamic amplification effect in the toppling slope. The impacts of the structural planes in the models on their wave propagation characteristics and magnification effect were discussed. Directions of ground motion have impacts on the dynamic response of the models. Based on the frequency-domain analysis, the relationship between the frequency of waves and the dynamic response of the models was further studied. The geological structure have a great effect on the high-frequency components of waves. The analyses of marginal spectrum show that the energy mainly concentrated in the frequency band of seismic wave (7-10 Hz). Moreover, the seismic failure mechanism of the toppling rock slope was discussed. Geological structure determines the seismic failure mode of the slope. Cracks initiate in the top toppling plane, and the surface slope is damaged firstly under earthquake excitation; with the increase of seismic loading, a large-scale slip mass further forms gradually from the upper to the lower slope body.
Evaluation of the Self-reported Questionnaires used to Assess Mental Health After the January 2015 Terrorist Attacks in the Paris Region: IMPACTS Survey
Authors: Bertuzzi Leticia , Heron Megane , Aubert Lyderic , Motreff Yvon , Pirard Philippe , Paranhos Mariana Esteves , Corte Francesco Della , Vuillermoz Cécile , Vandentorren Stéphanie , Aarbaoui Tarik El 
Published: March 2021

Abstract
Background: Gold standard measures in mental health are composed of structured clinical interviews. The design of a study could impede using gold standard measures. Several self-report questionnaires are then used to screen for a number of psychiatric symptoms. Therefore, the need to understand which among those would be most appropriate to be applied after terrorism. The present study examined the performance of self-report questionnaires used to assess post-traumatic stress disorder (PCL-S) and symptoms of depression and anxiety (HADS) compared to the MINI among civilians and first responders involved in terror attacks. Methods: This study was based on the data from the IMPACTS Survey conducted from 6 to10 months among civilians (N=190) and first responders (N=232) after the January 2015 terrorist attacks in the Paris Region, France. Sensitivity and specificity of the PCL-S and HADS were estimated by the ROC curve. The optimal threshold for each of the questionnaires was defined using the Youden index. The area under the curve was determined to assess the ability of the instruments to diagnose or score the proposed disorders. Results: Data of 190 civilians and 232 first responders were used to assess the performance of PCL-S and HADS. Concerning the PCL-S: for civilians, the overall AUC was 0.947, and the optimal threshold was 38.5; for first responders, the overall AUC was 0.899, and the optimal threshold was 39.5. Regarding the HADS-D: for civilians, the overall AUC was 0.908 and optimal threshold was 7.5; for first responders, the overall AUC was 0.617 and the “optimal” threshold was 1.5. About the HADS-A for civilians, the overall AUC was 0.823 and the optimal threshold was 9.5; for first responders, the overall AUC was 0.717 and the optimal threshold was 6.5. Conclusions: Our findings demonstrated a satisfactory performance of the PCL-S and the HAD-D to screen for PTSD or depression (respectively) compared to the MINI, and an unsatisfactory performance of the HAD-A to assess anxiety disorders compared to the MINI. It would be interesting if the study were replicated in other countries and in different types of disaster.
FLOURY ENDOSPERM19 encoding a class I glutamine amidotransferase affects grain quality in rice
Authors: Lou Guangming , Chen Pingli , Zhou Hao , Li Pingbo , Xiong Jiawang , Wan Shanshan , Zheng Yuanyuan , Alam Mufid , Liu Rongjia , Zhou Yin , Yang Hanyuan , Tian Yahong , Bai Jingjing , Rao Wenting , Tan Xuan , Gao Haozhou , Li Yanhua , Gao Guanjun , Zhang Qinglu , Li Xianghua , Liu Chuanguang , He Yuqing 
Published: March 2021

Abstract
As a staple food for more than half of the world’s population, the importance of rice is self-evident. Compared with ordinary rice, rice cultivars with superior eating quality and appearance quality are more popular with consumers due to its unique taste and ornamental value, even if their price is much higher. Appearance quality and CEQ (cooking and eating quality) are two very important aspects in the evaluation of rice quality. Here, we performed a genome-wide association study on chalkiness rate in a diverse panel of 533 cultivated rice accessions. We identified a batch of potential chalky genes and prioritize one (LOC_Os03g48060) for functional analyses. Two floury outer endosperm mutants (flo19-1 and flo19-2) were generated through editing LOC_Os03g48060 (named as FLO19 in this study), which encodes a class I glutamine amidotransferase. The different performance of the two mutants in various storage substances directly led to completely different changes in CEQ. The mutation of FLO19 gene caused the damage of carbon and nitrogen metabolism in rice, which affected the normal growth and development of rice, including decreased plant height and yield loss by decreased grain filling rate. Through haplotype analysis, we identified a haplotype of FLO19 that can improve both CEQ and appearance quality of rice, Hap2, which provides a selection target for rice quality improvement, especially for high-yield indica rice varieties.
Impact of the extent of resection on the survival of patients with lower-grade gliomas using awake brain mapping
Authors: Motomura Kazuya , Chalise Lushun , Ohka Fumiharu , Aoki Kosuke , Tanahashi Kuniaki , Hirano Masaki , Nishikawa Tomohide , Yamaguchi Junya , Shimizu Hiroyuki , Wakabayashi Toshihiko , Saito Ryuta 
Published: March 2021

Abstract
PurposeThe aim of this study was to assess the effect of the extent of resection (EOR) of tumors on survival in a series of patients with lower-grade gliomas (LGGs) who underwent awake brain mapping.MethodsWe retrospectively analyzed 126 patients with LGGs in the dominant and non-dominant hemisphere who underwent awake brain surgery at the same institution between December 2012 and May 2020.ResultsThe median progression-free survival (PFS) rate of patients with LGGs in the group with an EOR > 100 %, including supratotal resection (n = 47; median survival [MS], not reached), was significantly higher than that in the group with an EOR < 100% (n = 79; MS, 43.1 months; 95% CI: 37.8–48.4 months; p = 0.04). In patients with diffuse astrocytomas and anaplastic astrocytomas, the group with EOR > 100 %, including supratotal resection (n = 25; MS, not reached), demonstrated a significantly better PFS rate than did the group with an EOR < 100% (n = 45; MS, 35.8 months; 95% CI: 19.9–51.6 months; p = 0.03). Supratotal or gross total resection was correlated with better PFS in IDH-mutant type of diffuse astrocytomas and anaplastic astrocytomas (n = 19; MS, not reached vs. n = 35; MS, 40.6 months; 95% CI: 22.3–59.0 months; p = 0.02). By contrast, supratotal or gross total resection was not associated with longer PFS rates in patients with IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas. ConclusionsIt is noteworthy that supratotal or gross total resection significantly correlated with better PFS in IDH-mutant type of WHO grade II and III astrocytic tumors. In light of our finding that EOR did not correlate with PFS in patients with aggressive IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas, we suggest treatments that are more intensive will be needed for the control of these tumors.
Improvement of the optical and photocatalytic properties of ZnAl2O4: 1% La3+, x% Pb2+ nanoparticles synthesized by citrate sol-gel route
Authors: Filali Hichem , Boukheit Nahman , Bouhroum Rafika , Chekirou Wassila , Karaali Ahcène 
Published: March 2021

Abstract
Samples of pure zinc aluminate (ZnAl2O4) and doped both with lead (Pb2+) at different ratios (0, 0.5, 1, 1.5, 2 and 2.5% mol) and a constant amount of lanthanum (La: 1% mol), were prepared by the citrate sol-gel technique, and then annealed at 900°C for 2h. In order to study the structural, optical and thermal properties; different characterization methods were used, such as: powder X-ray diffraction (XRD), scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDX), differential scanning calorimetry (DSC), TGA, Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. The Analyzes by XRD revealed the presence of the cubic single phase ZnAl2O4 for all samples, with a crystallites size between 19 and 25 nm. These results were confirmed using FTIR, Raman spectroscopy and SEM. Also, photocatalytic study for different samples of ZnAl2O4 shows that they can be used like as photocatalyst and good adsorbents for degradation of Hexamethyl crystallized violet dye in aqueous solution.
Clinical Phenotypes from Fatal Cases of Acute Respiratory Distress Syndrome Caused by Pneumonia
Authors: Ichikado Kazuya , Kawamura Kodai , Johkoh Takeshi , Fujimoto Kiminori , Shintani Ayumi , Hashimoto Satoru , Eguchi Yoshitomo , Yasuda Yuko , Anan Keisuke , Shingu Naoki , Sakata Yoshihiko , Hisanaga Junpei , Nitawaki Tatsuya , Iio Miwa , Sekido Yuko , Nishiyama Kenta , Nakamura Kazunori , Suga Moritaka , Ichiyasu Hidenori , Sakagami Takuro 
Published: March 2021

Abstract
Background: The COVID-19 pandemic has renewed interest and discussion about clinical phenotypes of acute respiratory distress syndrome (ARDS). Since the Berlin definition, various clinical disease courses with fatal outcome have been described but early objective indicators predicting distinct clinical courses have remained elusive. Objectives: Identify clinically available predictors that distinguish between two phenotypes of fatal ARDS due to pneumonia.Methods: 104 Japanese patients with pneumonia induced ARDS were extracted from our prospectively collected database. Fatal cases were divided into early (< 7 days after diagnosis) and late death (≥ 7 days) groups and their clinical variables and prognostic factors were statistically evaluated.Results: Of 50 cases, fatal within 180 days, 18 (36%) comprised the early death group (median 2 days, IQR [1, 5]) and 32 (64%), the late death group (median 16 days, IQR [13, 29]). Multivariate regression analyses showed APACHE II score (HR 1.14, 95%CI 1.01-1.28, p 0.047) was the only independent prognostic factor for early death. Late deaths were associated with disseminated intravascular coagulation score (HR 1.30, 95%CI 1.07-1.58, p 0.007), culture sensitivity to initial antimicrobials (HR 3.42, 95%CI 1.86-6.29, p <0.0001), and high-resolution computed tomography (HRCT) score indicating early fibroproliferation. ROC analyses estimated a late death propensity score for HRCT score ≥ 211, of 5.42 (95%CI 1.54–19.12; p 0.008).Conclusions: The extent of fibroproliferation on HRCT, along with coagulation abnormalities and APACHE II scores, should be considered for use in predictive trial enrichment and personalized medicine for patients with ARDS due to pneumonia.
Real-Time Chatter Detection via Iterative Vold-Kalman Filter and Energy Entropy
Authors: Dong Xingjian , Tu Guowei , Wang Xiaoshan , Chen Shiqian 
Published: March 2021

Abstract
Real-time chatter detection is important in improving the surface quality of workpieces in milling. Since the process from stable cutting to chatter is characterized by the progressive variation of the vibration energy distribution, entropy has been utilized to capture the decreasing randomness of vibration signals when chatter occurs. To make such an index more sensitive to transitions of the cutting state, the entropy can be computed based on signal components obtained through signal decomposition techniques. However, the classic empirical mode decomposition (EMD) is difficult to put into practice due to its weak robustness to noises. The up-to-date variational mode decomposition (VMD) has strict requirements on priori information of the signal and thus is not applicable either. In this paper, a novel method named the iterative Vold-Kalman filter (I-VKF) is proposed under the framework of the greedy algorithm, where the Vold-Kalman filter (VKF), a classic order-tracker for rotating machinery, is improved to recursively extract each signal component. In the meantime, a spectrum concentration index-based technique is developed for the instantaneous chatter frequency estimation to adaptively determine the filter parameter. Numerical examples demonstrate the superiority of the I-VKF over the original VKF, EMD, and VMD, especially in the presence of strong noises. Combined with the energy entropy of extracted components and an automatically calculated threshold, the proposed strategy greatly helps in timely chatter detection, which has been verified by dynamic simulation and experiments.
Serum exosomal miR-4787-3p as potential lymph node metastasis and prognostic marker in esophageal squamous cell carcinoma.
Authors: Liu Shuang , Lin Zheng , Wang Jianwen , Zheng Zerong , Rao Wenqing , Liu Zhiqiang , Chen Yuanmei , Zeng Qiaoyan , Li Shanshan , Hu Zhijian 
Published: March 2021

Abstract
Background: To explore the miR-4787-3p expression levels in the serum exosome and tissue and its role in lymph node metastasis and prognosis in ESCC. Methods: The miRNA array was conducted to detect the ESCC serum exosomal miRNAs expression. A receiver operating characteristic (ROC) curve was constructed to determine the predictive ESCC with lymph node metastasis efficacy of serum exosomal miR-4784-3p. The Cox regression analysis was preformed to explore prognostic factors for ESCC. Transwell assay and CCK-8 assays were utilized to evaluate cell migration, invasion, and proliferation, respectively. Results: High serum exosomal miR-4787-3p expression was demonstrated in lymph node metastasis group (P =0.011). The serum exosomal miR-4787-3p expression was significantly associated with histologic grade (P = 0.010), and TNM stage (P = 0.033). However, there was no significant relationship between tissue miR-4787-3p expression and clinical characteristics (P >0.05). ROC analyses revealed that the AUCs of serum exosomal miR-4787-3p for lymph node metastasis prediction was 0.787. The Cox regression analysis found that high expression serum exosomal miR-4787-3p were correlated with poor prognoses (for OS, HR=2.68, 95% CI: 1.02~7.04; for DFS, HR = 2.65, 95% CI: 1.05~6.68). Nevertheless, no association between tissue miR-4787-3p expression and ESCC prognosis. In addition, upregulated expression of miR-4787-3p could promote migration and invasion in vitro. Conclusions: Serum exosomal miR-4787-3p can be promising biomarkers for ESCC metastasis and prognosis
Text Fingerprinting and Topic Mining in the Prescription Opioid Use Literature
Authors: Le Huyen , Zhou Junxiu , Zhao Weizhong , Perkins Roger , Ge Weigong , Lyn-Cook Beverly , Francis Henry , Hong Huixiao , Tong Weida , Zou Wen 
Published: March 2021

Abstract
Background Prescription opioids are powerful pain-reducing medications, but they may cause a variety of adverse effects. Long-term prescription opioid use (POU) is contributing to an opioid-related epidemic of addiction and death, and the scope of the opioid crisis continues to expand. As such, there is a need to identify the adverse effects associated with prescription opioid use (POU). Thousands of articles that focus on POU and its associated medical disorders have been published. However, it is time-consuming and labor-intensive to extract and understand the information of all POU-related published articles.Methods In this study, we applied the well-adapted topic modeling method, Latent Dirichlet Allocation (LDA), to perform text mining on POU-related literature. We compiled six large academic abstract datasets by searching PubMed using the Medical Subject Headings (MeSH): prescription opioid, codeine, morphine, hydrocodone, oxycodone, and methadone. We then applied topic modeling to identify topics and analyze topic similarities/differences in these six datasets. Word clouds and histograms were used to depict the distribution of vocabularies over each topic in which the most prevalent words conveyed a topic’s substance.Results The LDA topics recaptured the search keywords in PubMed, and further revealed relevant themes, such as patients, drugs, side effects, and association links between different POU and risk factors, such as gender and age. Moreover, based on the topic modeling results, TreeMap was used to fingerprint abstracts, which revealed the possibility of constructing a visualized literature index by combining topic modeling and visualization tools such as TreeMap. Meanwhile, while performing trend analysis to explore the prevalent topic dynamics in the POU-related literature, we found that an increasing trend in opioid prescription and its associated health risks are assessed as the most central issues.Conclusion The topic modeling results presented in this study not only convey an understandable and thematic structure of the POU literature, but also provide a means to discover which documents contain information about medical disorders associated with POU, thus, reducing the time and effort needed to review the literature for relevant articles. These results can be used as a preliminary study to systematically understand the risk factors related to increased POU-associated medical disorders.