bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Missing Magmatic Arc in a Long‐Lived Ocean From the Western Kunlun‐ Pamir Paleo‐Tethys Realm
Authors: Tang Gong‐Jian , Cawood Peter A. , Wyman Derek A. , Dan Wei , Wang Qiang , Yang Ya‐Nan 
Published: November 2021

AbstractThe evolution of the western Kunlun‐Pamir region involved the opening and closing of several branches of the Paleo‐Tethys Ocean, although the specific timing of these events is poorly constrained. Here, we present a synthesis of sedimentary, magmatic, and metamorphic records associated from the Mazar‐Kangxiwa suture zone in the western Kunlun‐Pamir that is generally regarded as the main Paleo‐Tethys Ocean suture. These data show that the Paleo‐Tethyan oceanic basin opened at ca. 340 Ma and closed by ca. 250 Ma, and there is no record of a magmatic arc between ca. 300–250 Ma. The absence of a magmatic arc was a result of oceanic crust underthrusting, rather than oceanic subduction, which is consistent with a narrow back‐arc basin. Our study provides an important example of how an oceanic basin opened and closed without oceanic subduction, and highlights a potential mechanism to account for the absence of a magmatic arc.
Indirect Measurements of the Composition of Ultrafine Particles in the Arctic Late‐Winter
Authors: Myers Deanna C. , Lawler Michael J. , Mauldin Roy L. , Sjostedt Steven , Dubey Manvendra , Abbatt Jonathan , Smith James N. 
Published: November 2021

AbstractWe present indirect measurements of size‐resolved ultrafine particle composition conducted during the Ocean‐Atmosphere‐Sea Ice‐Snowpack (OASIS) Campaign in Utqiagvik, Alaska, during March 2009. This study focuses on measurements of size‐resolved particle hygroscopicity and volatility measured over two periods of the campaign. During a period that represents background conditions in this location, particle hygroscopic growth factors (HGF) at 90% relative humidity ranged from 1.45 to 1.51, which combined with volatility measurements suggest a mixture of ∼30% ammoniated sulfates and ∼70% oxidized organics. Two separate regional ultrafine particle growth events were also observed during this campaign. Event 1 coincided with elevated levels of H2SO4 and solar radiation. These particles were highly hygroscopic (HGF = 2.1 for 35 nm particles), but were almost fully volatilized at 160 °C. The air masses associated with both events originated over the Arctic Ocean. Event 1 was influenced by the upper marine boundary layer (200–350 m AGL), while Event 2 spent more time closer to the surface (50–150 m AGL) and over open ocean leads, suggesting marine influence in growth processes. Event 2 particles were slightly less hygroscopic (HGF = 1.94 for 35 nm and 1.67 for 15 nm particles), and similarly volatile. We hypothesize that particles formed during both events contained 60–70% hygroscopic salts by volume, with the balance for Event 1 being sulfates and oxidized organics for Event 2. These observations suggest that primary sea spray may be an important initiator of ultrafine particle formation events in the Arctic late‐winter, but a variety of processes may be responsible for condensational growth.
Implementation and Evaluation of a Unified Turbulence Parameterization Throughout the Canopy and Roughness Sublayer in Noah‐MP Snow Simulations
Authors: Abolafia‐Rosenzweig Ronnie , He Cenlin , Burns Sean P. , Chen Fei 
Published: November 2021

AbstractThe Noah‐MP land surface model (LSM) relies on the Monin‐Obukhov (M‐O) Similarity Theory (MOST) to calculate land‐atmosphere exchanges of water, energy, and momentum fluxes. However, MOST flux‐profile relationships neglect canopy‐induced turbulence in the roughness sublayer (RSL) and parameterize within‐canopy turbulence in an ad hoc manner. We implement a new physics scheme (M‐O‐RSL) into Noah‐MP that explicitly parameterizes turbulence in RSL. We compare Noah‐MP simulations employing the M‐O‐RSL scheme (M‐O‐RSL simulations) and the default M‐O scheme (M‐O simulations) against observations obtained from 647 Snow Telemetry (SNOTEL) stations and two AmeriFlux stations in the western United States. M‐O‐RSL simulations of snow water equivalent (SWE) outperform M‐O simulations over 64% and 69% of SNOTEL sites in terms of root‐mean‐square‐error (RMSE) and correlation, respectively. The largest improvements in skill for M‐O‐RSL occur over closed shrubland sites, and the largest degradations in skill occur over deciduous broadleaf forest sites. Differences between M‐O and M‐O‐RSL simulated snowpack are primarily attributable to differences in aerodynamic conductance for heat underneath the canopy top, which modulates sensible heat flux. Differences between M‐O and M‐O‐RSL within‐canopy and below‐canopy sensible heat fluxes affect the amount of heat transported into snowpack and hence change snowmelt when temperatures are close to or above the melting point. The surface energy budget analysis over two AmeriFlux stations shows that differences between M‐O and M‐O‐RSL simulations can be smaller than other model biases (e.g., surface albedo). We intend for the M‐O‐RSL physics scheme to improve performance and uncertainty estimates in weather and hydrological applications that rely on Noah‐MP.
Improving a Biogeochemical Model to Simulate Microbial‐Mediated Carbon Dynamics in Agricultural Ecosystems
Authors: Deng Jia , Frolking Steve , Bajgain Rajen , Cornell Carolyn R. , Wagle Pradeep , Xiao Xiangming , Zhou Jizhong , Basara Jeffrey , Steiner Jean , Li Changsheng 
Published: November 2021

AbstractSoil microbes drive decomposition of soil organic matter (SOM) and regulate soil carbon (C) dynamics. Process‐based models have been developed to quantify changes in soil organic carbon (SOC) and carbon dioxide (CO2) fluxes in agricultural ecosystems. However, microbial processes related to SOM decomposition have not been, or are inadequately, represented in these models, limiting predictions of SOC responses to changes in microbial activities. In this study, we developed a microbial‐mediated decomposition model based on a widely used biogeochemical model, DeNitrification‐DeComposition (DNDC), to simulate C dynamics in agricultural ecosystems. The model simulates organic matter decomposition, soil respiration, and SOC formation by simulating microbial and enzyme dynamics and their controls on decomposition, and considering impacts of climate, soil, crop, and farming management practices (FMPs) on C dynamics. When evaluated against field observations of net ecosystem CO2 exchange (NEE) and SOC change in two winter wheat systems, the model successfully captured both NEE and SOC changes under different FMPs. Inclusion of microbial processes improved the model's performance in simulating peak CO2 fluxes induced by residue return, primarily by capturing priming effects of residue inputs. We also investigated impacts of microbial physiology, SOM, and FMPs on soil C dynamics. Our results demonstrated that residue or manure input drove microbial activity and predominantly regulated the CO2 fluxes, and manure amendment largely regulated long‐term SOC change. The microbial physiology had considerable impacts on the microbial activities and soil C dynamics, emphasizing the necessity of considering microbial physiology and activities when assessing soil C dynamics in agricultural ecosystems.
Stratospheric X‐Rays Detected at Midlatitudes With a Miniaturized Balloon‐Borne Microscintillator‐PiN Diode System
Authors: Aplin K. L. , Marlton G. J. , Race V. 
Published: November 2021

AbstractA miniaturized scintillator (“microscintillator”), was flown on a meteorological radiosonde to observe energetic particles in the lower atmosphere. A PiN diode was used to measure the light from the microscintillator to count rates and energies of ionizing radiation from the ground up to the stratosphere (32 km). The flight, over the southern UK on August 27, 2018, occurred during a geomagnetic storm. Low‐energy (50–150 keV) particles in the stratosphere were detected in addition to the usual signal from higher‐energy cosmic rays. Unusually for these miniaturized radiosonde systems, which are designed to be disposable, the payload was retrieved. This allowed for re‐calibration of the microscintillator, which confirmed the low‐energy particle detection. Laboratory tests excluded thermal effects on the microscintillator instrument as the origin of the signal. Data from the NOAA POES spacecraft offer the explanation that the microscintillator detected bremstrahhlung X‐rays from energetic electron precipitation (EEP). EEP events may affect weather and climate through a range of physical mechanisms, and this midlatitude observation, well away from the auroral oval, extends the region over which meteorological effects of EEPs need to be assessed. Our findings underline the value of balloon measurements in providing rapid response to space weather events. The energy‐discriminating and altitude‐sensitive capability of the microscintillator augments spacecraft observations from below.
Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP
Authors: Xie Guohua , Dong Ping , Chen Hui , Xu Ling , Liu Yi , Ma Yanhui , Zheng Yingxia , Yang Junyao , Zhou Yunlan , Chen Lei , Shen Lisong 
Published: November 2021

AbstractATF3 has been reported to be dysregulated in various cancers and involved in various steps of tumorigenesis. However, the mechanisms underlying the abnormal expression of ATF3 and its biological function in gastric cancer (GC) have not been well investigated. Here, we report ATF3 as one of the key regulators of GC development and progression. Patients with low ATF3 expression had shorter survival and a poorer prognosis. In vitro and in vivo assays investigating ATF3 alterations revealed a complex integrated phenotype that affects cell growth and migration. Strikingly, high-throughput sequencing and microarray analysis of cells with ATF3 silencing or of ATF3-low GC tissues indicated alterations in the Wnt signaling pathway, focal adhesions and adherens junctions. Mechanistically, the expression of β-catenin and cell migration inducing hyaluronidase 1 (CEMIP) was significantly upregulated in GC cells with downregulated ATF3, which was synergistically repressed by the β-catenin/TCF3 signaling axis and noncoding RNA miR-17-5p and HOXA11-AS. In addition, we found that WDR5 expression was promoted by TCF3 and is involved in miR-17-5p and HOXA11-AS activation in GC cells. Taken together, our findings revealed the mechanism of ATF3 downregulation and its biological role in regulating the expression of Wnt signaling-related genes during GC progression, suggesting new informative biomarkers of malignancy and therapeutic directions for GC patients.
LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer
Authors: Luo Wenjie , Wang Jun , Xu Wenhao , Ma Chunguang , Wan Fangning , Huang Yongqiang , Yao Mengfei , Zhang Hailiang , Qu Yuanyuan , Ye Dingwei , Zhu Yiping 
Published: November 2021

AbstractLong non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and progression in bladder cancer. Here we further explored the function of RP11-89, a lncRNA discovered in the previous signature. Loss- and gain-of function experiments were performed using CCK-8 assay, flow cytometry, Transwell assays, scratch tests and subcutaneous nude mouse models. High-throughput RNA sequencing was conducted to identify dysregulated genes in bladder cancer cells with RP11-89 knockdown or overexpression. Regulation of RP11-89 on miR-129-5p and PROM2 was explored through luciferase reporter assay, RIP assay and RNA pull-down assay. RP11-89 promoted cell proliferation, migration and tumorigenesis and inhibited cell cycle arrest via the miR-129-5p/PROM2 axis. We found that RP11-89 “sponges” miR-129-5p and upregulates PROM2. Elevated PROM2 in cells was associated with attenuated ferroptosis through iron export, formation of multivesicular bodies and less mitochondrial abnormalities. We demonstrated that RP11-89 is a novel tumorigenic regulator that inhibits ferroptosis via PROM2-activated iron export. RP11-89 may serve as a potential biomarker for targeted therapy in bladder cancer.
ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway
Authors: Lin Yun , Li Chun , Xiong Wei , Fan Liping , Pan Hongchao , Li Yaochen 
Published: November 2021

AbstractAdvanced breast cancer (BC), especially basal like triple-negative BC (TNBC), is a highly malignant tumor without viable treatment option, highlighting the urgent need to seek novel therapeutic targets. Arylsulfatase D (ARSD), localized at Xp22.3, is a female-biased gene due to its escaping from X chromosome inactivation (XCI). Unfortunately, no systematic investigation of ARSD on BC has been reported. In this study, we observed that ARSD expression was positively related to ERα status either in BC cells or tissue specimens, which were associated with good prognosis. Furthermore, we found a set of hormone-responsive lineage-specific transcription factors, FOXA1, GATA3, ERα, directly drove high expression of ARSD through chromatin looping in luminal subtype BC cells. Opposingly, ARSD still subjected to XCI in TNBC cells mediated by Xist, CpG islands methylation, and inhibitory histone modification. Unexpectedly, we also found that ectopic ARSD overexpression could inhibit proliferation and migration of TNBC cells by activating Hippo/YAP pathway, indicating that ARSD may be a molecule brake on ERα signaling pathway, which restricted ERα to be an uncontrolled active status. Combined with other peoples’ researches that Hippo signaling maintained ER expression and ER + BC growth, we believed that there should exist a regulative feedback loop formation among ERα, ARSD, and Hippo/YAP pathway. Collectively, our findings will help filling the knowledge gap about the influence of ARSD on BC and providing evidence that ARSD may serve as a potential marker to predict prognosis and as a therapeutic target.
Compound jetting from bubble bursting at an air-oil-water interface
Authors: Ji Bingqiang , Yang Zhengyu , Feng Jie 
Published: November 2021

AbstractBursting of bubbles at a liquid surface is ubiquitous in a wide range of physical, biological, and geological phenomena, as a key source of aerosol droplets for mass transport across the interface. However, how a structurally complex interface, widely present in nature, mediates the bursting process remains largely unknown. Here, we document the bubble-bursting jet dynamics at an oil-covered aqueous surface, which typifies the sea surface microlayer as well as an oil spill on the ocean. The jet tip radius and velocity are altered with even a thin oil layer, and oily aerosol droplets are produced. We provide evidence that the coupling of oil spreading and cavity collapse dynamics results in a multi-phase jet and the follow-up droplet size change. The oil spreading influences the effective viscous damping, and scaling laws are proposed to quantify the jetting dynamics. Our study not only advances the fundamental understanding of bubble bursting dynamics, but also may shed light on the airborne transmission of organic matters in nature related to aerosol production.
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Authors: Kyrousi Christina , O’Neill Adam C. , Brazovskaja Agnieska , He Zhisong , Kielkowski Pavel , Coquand Laure , Di Giaimo Rossella , D’ Andrea Pierpaolo , Belka Alexander , Forero Echeverry Andrea , Mei Davide , Lenge Matteo , Cruceanu Cristiana , Buchsbaum Isabel Y. , Khattak Shahryar , Fabien Guimiot , Binder Elisabeth , Elmslie Frances , Guerrini Renzo , Baffet Alexandre D. , Sieber Stephan A. , Treutlein Barbara , Robertson Stephen P. , Cappello Silvia 
Published: November 2021

AbstractBasal progenitors (BPs), including intermediate progenitors and basal radial glia, are generated from apical radial glia and are enriched in gyrencephalic species like humans, contributing to neuronal expansion. Shortly after generation, BPs delaminate towards the subventricular zone, where they further proliferate before differentiation. Gene expression alterations involved in BP delamination and function in humans are poorly understood. Here, we study the role of LGALS3BP, so far known as a cancer biomarker, which is a secreted protein enriched in human neural progenitors (NPCs). We show that individuals with LGALS3BP de novo variants exhibit altered local gyrification, sulcal depth, surface area and thickness in their cortex. Additionally, using cerebral organoids, human fetal tissues and mice, we show that LGALS3BP regulates the position of NPCs. Single-cell RNA-sequencing and proteomics reveal that LGALS3BP-mediated mechanisms involve the extracellular matrix in NPCs’ anchoring and migration within the human brain. We propose that its temporal expression influences NPCs’ delamination, corticogenesis and gyrification extrinsically.
Bird population declines and species turnover are changing the acoustic properties of spring soundscapes
Authors: Morrison C. A. , Auniņš A. , Benkő Z. , Brotons L. , Chodkiewicz T. , Chylarecki P. , Escandell V. , Eskildsen D. P. , Gamero A. , Herrando S. , Jiguet F. , Kålås J. A. , Kamp J. , Klvaňová A. , Kmecl P. , Lehikoinen A. , Lindström Å. , Moshøj C. , Noble D. G. , Øien I. J. , Paquet J-Y. , Reif J. , Sattler T. , Seaman B. S. , Teufelbauer N. , Trautmann S. , van Turnhout C. A. M. , Vořišek P. , Butler S. J. 
Published: November 2021

AbstractNatural sounds, and bird song in particular, play a key role in building and maintaining our connection with nature, but widespread declines in bird populations mean that the acoustic properties of natural soundscapes may be changing. Using data-driven reconstructions of soundscapes in lieu of historical recordings, here we quantify changes in soundscape characteristics at more than 200,000 sites across North America and Europe. We integrate citizen science bird monitoring data with recordings of individual species to reveal a pervasive loss of acoustic diversity and intensity of soundscapes across both continents over the past 25 years, driven by changes in species richness and abundance. These results suggest that one of the fundamental pathways through which humans engage with nature is in chronic decline, with potentially widespread implications for human health and well-being.
Distinct methane-dependent biogeochemical states in Arctic seafloor gas hydrate mounds
Authors: Klasek Scott A. , Hong Wei-Li , Torres Marta E. , Ross Stella , Hostetler Katelyn , Portnov Alexey , Gründger Friederike , Colwell Frederick S. 
Published: November 2021

AbstractArchaea mediating anaerobic methane oxidation are key in preventing methane produced in marine sediments from reaching the hydrosphere; however, a complete understanding of how microbial communities in natural settings respond to changes in the flux of methane remains largely uncharacterized. We investigate microbial communities in gas hydrate-bearing seafloor mounds at Storfjordrenna, offshore Svalbard in the high Arctic, where we identify distinct methane concentration profiles that include steady-state, recently-increasing subsurface diffusive flux, and active gas seepage. Populations of anaerobic methanotrophs and sulfate-reducing bacteria were highest at the seep site, while decreased community diversity was associated with a recent increase in methane influx. Despite high methane fluxes and methanotroph doubling times estimated at 5–9 months, microbial community responses were largely synchronous with the advancement of methane into shallower sediment horizons. Together, these provide a framework for interpreting subseafloor microbial responses to methane escape in a warming Arctic Ocean.
Subglacial discharge controls seasonal variations in the thermal structure of a glacial lake in Patagonia
Authors: Sugiyama Shin , Minowa Masahiro , Fukamachi Yasushi , Hata Shuntaro , Yamamoto Yoshihiro , Sauter Tobias , Schneider Christoph , Schaefer Marius 
Published: November 2021

AbstractWater temperature in glacial lakes affects underwater melting and calving of glaciers terminating in lakes. Despite its importance, seasonal lake temperature variations are poorly understood because taking long-term measurements near the front of calving glaciers is challenging. To investigate the thermal structure and its seasonal variations, we performed year-around temperature and current measurement at depths of 58–392 m in Lago Grey, a 410-m-deep glacial lake in Patagonia. The measurement revealed critical impacts of subglacial discharge on the lake thermal condition. Water below a depth of ~100 m showed the coldest temperature in mid-summer, under the influence of glacial discharge, whereas temperature in the upper layer followed a seasonal variation of air temperature. The boundary of the lower and upper layers was controlled by the depth of a sill which blocks outflow of dense and cold glacial meltwater. Our data implies that subglacial discharge and bathymetry dictate mass loss and the retreat of lake-terminating glaciers. The cold lakewater hinders underwater melting and facilitates formation of a floating terminus.
The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
Authors: Sekiya Motohiro , Kainoh Kenta , Sugasawa Takehito , Yoshino Ryunosuke , Hirokawa Takatsugu , Tokiwa Hiroaki , Nakano Shogo , Nagatoishi Satoru , Tsumoto Kouhei , Takeuchi Yoshinori , Miyamoto Takafumi , Matsuzaka Takashi , Shimano Hitoshi 
Published: November 2021

AbstractBiological systems to sense and respond to metabolic perturbations are critical for the maintenance of cellular homeostasis. Here we describe a hepatic system in this context orchestrated by the transcriptional corepressor C-terminal binding protein 2 (CtBP2) that harbors metabolite-sensing capabilities. The repressor activity of CtBP2 is reciprocally regulated by NADH and acyl-CoAs. CtBP2 represses Forkhead box O1 (FoxO1)-mediated hepatic gluconeogenesis directly as well as Sterol Regulatory Element-Binding Protein 1 (SREBP1)-mediated lipogenesis indirectly. The activity of CtBP2 is markedly defective in obese liver reflecting the metabolic perturbations. Thus, liver-specific CtBP2 deletion promotes hepatic gluconeogenesis and accelerates the progression of steatohepatitis. Conversely, activation of CtBP2 ameliorates diabetes and hepatic steatosis in obesity. The structure-function relationships revealed in this study identify a critical structural domain called Rossmann fold, a metabolite-sensing pocket, that is susceptible to metabolic liabilities and potentially targetable for developing therapeutic approaches.