bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Effect of Daily Physical Activity and Social Relationships on Sleep Disorder Among Older Adults: A Cross-Sectional Study Based on Data From The Kasama Study
Authors: Seol Jaehoon , Lee Jaehee , Nagata Koki , Fujii Yuya , Joho Kaya , Tateoka Korin , Inoue Taiki , Liu Jue , Okura Tomohiro 
Published: January 2021

Abstract
Background: This cross-sectional study investigated whether the daily physical activity of older adults, combined with social relationships, is associated with the risk of sleep disorder. Further, it determined whether a high level of one variable with a low level of the other leads to a significantly lower risk of sleep disorder than low levels of both. Methods: The sample comprised 988 community-dwelling older Japanese adults (mean age: 73.1 ± 5.5 years). The level of daily physical activity and range of social relationships were assessed using the Physical Activity Scale for the Elderly and the Lubben Social Network Scale, respectively. The Pittsburgh Sleep Quality Index was used to assess sleep disorder. To test linear trends and the combined effect of the two variables, both variable values were divided into tertiles. To test the combined effects, medians were calculated for the respective scores, based on which the participants were categorized into the following groups: (1) inactive with a narrow range of social relationships (n = 307), (2) inactive with a wide range of social relationships (n = 183), (3) active with a narrow range of social relationships (n = 205), and (4) active with a wide range of social relationships (n = 293). After adjusting for potential confounders, a logistic regression analysis was conducted. Results: Participants who were more physically active (odds ratio [OR]: 0.694, 95% confidence interval [CI]: 0.484–0.997) and those with a wide range of social relationships (OR: 0.690, 95% CI: 0.481–0.988) showed a lower prevalence of sleep disorder than those in the first tertile; these effects were independent of each other. The combined effect analysis revealed that the active group with a wide range of social relationships showed a significantly lower prevalence of sleep disorder (OR: 0.585, 95% CI: 0.404–0.847) than the inactive group with a narrow range of social relationships.Conclusions: Our findings suggest that being physically active with a wide range of social relationships is favorably associated with sleep quality. However, a high level of one variable with a low level of the other is inefficient in improving sleep quality among older adults.
Models for forecasting water demand using time series analysis: a case study in Southern Brazil
Authors: Ristow Danielle C. M. , Henning Elisa , Kalbusch Andreza , Petersen Cesar E. 
Published: January 2021

Abstract
Technology has been increasingly applied in search for excellence in water resource management. Tools such as demand-forecasting models provide information for utility companies to make operational, tactical and strategic decisions. Also, the performance of water distribution systems can be improved by anticipating consumption values. This work aimed to develop models to conduct monthly urban water demand forecasts by analyzing time series, and adjusting and testing forecast models by consumption category, which can be applied to any location. Open language R was used, with automatic procedures for selection, adjustment, model quality assessment and forecasts. The case study was conducted in the city of Joinville, with water consumption forecasts for the first semester of 2018. The results showed that the seasonal ARIMA method proved to be more adequate to predict water consumption in four out of five categories, with mean absolute percentage errors varying from 1.19 to 15.74%. In addition, a web application to conduct water consumption forecasts was developed.
Residential water demand modelling and hydraulic reliability in design of building water supply systems: a review
Authors: Mangalekar R. D. , Gumaste K. S. 
Published: January 2021

Abstract
The building water supply system is a fundamental unit in water supply systems as it is directly associated with end users. However, the studies available on its efficient design are limited. Water demand estimation continues to be an important issue in water supply systems' design because of its multifaceted nature. Hunter's curve, or Fixture Unit method, is widely used for estimating the load on plumbing. Regardless of its popularity, it has a few drawbacks and is arbitrarily modified in some plumbing codes. Fixture-use probability, a basic entity in the Fixture Unit and some other methods, is a difficult parameter to estimate. Commonly, high-resolution field data is used for stochastic modelling of residential water demand which may not be always available. The paper reviews important residential water demand models in view of their applicability in building water supply system design. The irregular nature of water demand in buildings is due to uncertainty in water-use behaviour of users at fixture level. Use of soft-computing techniques can provide an advantage over the other methods in modelling such behaviour. The paper also discusses reliability of building water supply systems and applicability of some common indices for estimating reliability of building water supply systems.
The Influence of Media Coverage and Governmental Policies on Google Queries Related to COVID-19 Cutaneous Symptoms: Infodemiology Study
Authors: Huynh Dagher Solene , Lamé Guillaume , Hubiche Thomas , Ezzedine Khaled , Duong Tu Anh 
Published: January 2021

Background
During COVID-19, studies have reported the appearance of internet searches for disease symptoms before their validation by the World Health Organization. This suggested that monitoring of these searches with tools including Google Trends may help monitor the pandemic itself. In Europe and North America, dermatologists reported an unexpected outbreak of cutaneous acral lesions (eg, chilblain-like lesions) in April 2020. However, external factors such as public communications may also hinder the use of Google Trends as an infodemiology tool.

Objective
The study aimed to assess the impact of media announcements and lockdown enforcement on internet searches related to cutaneous acral lesions during the COVID-19 outbreak in 2020.

Methods
Two searches on Google Trends, including daily relative search volumes for (1) “toe” or “chilblains” and (2) “coronavirus,” were performed from January 1 to May 16, 2020, with the United States, the United Kingdom, France, Italy, Spain, and Germany as the countries of choice. The ratio of interest over time in “chilblains” and “coronavirus” was plotted. To assess the impact of lockdown enforcement and media coverage on these internet searches, we performed an interrupted time-series analysis for each country.

Results
The ratio of interest over time in “chilblains” to “coronavirus” showed a constant upward trend. In France, Italy, and the United Kingdom, lockdown enforcement was associated with a significant slope change for “chilblain” searches with a variation coefficient of 1.06 (SE 0.42) (P=0.01), 1.04 (SE 0.28) (P<.01), and 1.21 (SE 0.44) (P=0.01), respectively. After media announcements, these ratios significantly increased in France, Spain, Italy, and the United States with variation coefficients of 18.95 (SE 5.77) (P=.001), 31.31 (SE 6.31) (P<.001), 14.57 (SE 6.33) (P=.02), and 11.24 (SE 4.93) (P=.02), respectively, followed by a significant downward trend in France (–1.82 [SE 0.45]), Spain (–1.10 [SE 0.38]), and Italy (–0.93 [SE 0.33]) (P<.001, P=0.004, and P<.001, respectively). The adjusted R2 values were 0.311, 0.351, 0.325, and 0.305 for France, Spain, Italy, and the United States, respectively, suggesting an average correlation between time and the search volume; however, this correlation was weak for Germany and the United Kingdom.

Conclusions
To date, the association between chilblain-like lesions and COVID-19 remains controversial; however, our results indicate that Google queries of “chilblain” were highly influenced by media coverage and government policies, indicating that caution should be exercised when using Google Trends as a monitoring tool for emerging diseases.
Pengaruh Jenis Persalinan Bedah Sesar terhadap Kejadian Diare dan ISPA pada Bayi
Authors: Askar Nia Fararid , Wirakusumah Firman Fuad , L.T Maringan Diapari , Susiarno Hadi , Rusmil Kusnandi , Agustian Dwi 
Published: January 2021

Latar Belakang: Persalinan bedah sesar mempunyai risiko kegagalan pemberian ASI pada bayi karena durasi Inisiasi Menyusu Dini yang lebih singkat dan mobilisasi dini yang lebih lama daripada persalinan normal sehingga dapat mengakibatkan bayi rentan terhadap diare dan ISPA.Tujuan: Menganalisis pengaruh jenis persalinan bedah sesar dibandingkan dengan persalinan normal terhadap kejadian diare dan ISPA berdasarkan faktor: lama pemberian ASI Eksklusif, Inisiasi Menyusu Dini, mobilisasi dini, dan status imunisasi.Metode: Rancangan penelitian yang digunakan adalah studi kasus-kontrol. Sebanyak 220 responden (110 responden pada kejadian diare dan 110 responden pada kejadian ISPA) didapat berdasarkan rumus studi analitik komparatif tidak berpasangan dengan teknik pengambilan sampel consecutive sampling. Analisis data menggunakan uji regresi logistik.Hasil: Uji regresi logistik pada ibu dengan persalinan bedah sesar terhadap kejadian diare pada bayi nilai OR= 0,178 (0,065-0,486), Ibu dengan persalinan bedah sesar terhadap kejadian ISPA pada bayi mempunyai nilai OR= 2,773 (1,058-7,269).Kesimpulan: Persalinan bedah sesar dapat melindungi terhadap kejadian diare dan persalinan bedah sesar berisiko terhadap kejadian ISPA. Pemberian ASI Eksklusif dapat mencegah bayi dan balita dari kejadian diare dan ISPA.
RETINAL CHANGES IN PREGNANCY INDUCED-HYPERTENSION
Authors: ZADE MANDAR , VEERAMANI V. PANIMALAR A. , N. DIVYA , BHASKARAN BINDU 
Published: January 2021

Objective: The aim is to determine the prevalence of retinal changes in Pregnancy Induced Hypertension (PIH) and its association with age, parity, proteinuria, blood pressureand severity of PIH.
Methods: This is a tertiary hospital based Cross-Sectional study including all patients, clinically diagnosed with Pregnancy Induced Hypertension. General demographic details along with age, gravida, gestation period, proteinuria, blood pressure and severity of PIH were noted. Ophthalmic examination was performed and detailed fundus examination was done.
Results: A total of 52 patients were included in this study. Their mean age was 24.9 y; 32 out of 52 patients were primigravida (61%) and 20 patients were multi gravida (39%). Out of 52 patients 34 (65.38%) had Gestational Hypertension, 16 (30.76%) had preeclampsia, and 2 (3.8%) had eclampsia. 3 (5.76%) out of 29 patients with BP<160/100 mmHg and 10 (19.23%) out of 23 patients with BP>160/100 mmHg had developed Hypertensive Retinopathy. Hypertensive Retinopathy was seen in 13 (25%). Proteinuria was seen in 10 (19.23%) patients ranging between+to+++on the dipstick.
Conclusion: Statistically significant correlation between retinal changes and proteinuria, blood pressure and severity of Disease.The most important requisite in a case of Pregnancy Induced Hypertension is Fundoscopic examination of retina. The retinal vessels during PIH form a gateway to visualize changes in the body and placental vessels, and may play a key role in early detection and treatment of PIH for protection of the mother as well as the fetus.
PRE AND POST EXPOSURE ANALYSIS OF CHLORHEXIDINE GLUCONATE’S EFFECTIVENESS AGAINST BACTERIAL CONTAMINATION OF STETHOSCOPES
Authors: HARIKRISHNAN AISHWARYA , BHUVANESHWARI G. 
Published: January 2021

Objective: The present study is to assess the effectiveness of chlorhexidinegluconate as a disinfectant for the stethoscope diaphragm, to survey the routine practices followed by health care professionals (HCPs) towards stethoscope disinfection and to ascertain their general awareness on the matter.
Methods: Questionnaire-based study conducted to assess the degree of awareness and attitude of HCPs towards stethoscope disinfection procedures. 200 responses were obtained and analyzed. Randomized, blind trial comparing bacterial load of stethoscope post-exposure to chlorhexidinegluconate vs. ethyl alcohol. The swabs collected from stethoscope diaphragm before and after exposure to disinfectant, were cultured using spread plate technique on nutrient agar. CFU count was compared.
Results: Out of 200, nearly all HCPs part of this study were aware that stethoscopes could be linked to transmission of healthcare-associated infections (HCAIs) but only 78.5% (157) were accustomed to stethoscope disinfection practices. Although only 13.5% (27/200) of participants believed that chlorhexidinegluconate was effective, this study found it to be highly efficacious against bacterial recontamination.
Conclusion: We stress upon the importance of regular disinfection of the stethoscope after each use and encourage frequent cleaning of the device with chlorhexidinegluconate, which may reduce bacterial recontamination for a longer period.
PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY OF ACINETOBACTERIN A TERTIARY CARE HOSPITAL IN CHENNAI, INDIA
Authors: A. ANGELINE ANJALI , V. K. ABIRAMASUNDARI 
Published: January 2021

Objective: The present study is to determine the prevalence and antibiotic susceptibility of Acinetobacter species in samples collected from patients in tertiary care hospital in Chennai.
Methods: A total of17,827patient’s clinical samples were collected from various wards and ICUs of Saveetha Medical College and Hospital, Chennai, Tamilnadu over a period of 7 mo [between January 2020 and July 2020]. All samples were tested in the microbiology lab of Saveetha Medical College and Hospital using standard operating procedures.
Results: Out of 17,827 samples, 2,816 were culture positive. 122 of the isolates tested positive for Acinetobacter spp.and 81.1% of the isolates belonged to Acinetobacterbaumannii. Most of the infection occurred in the age group of 21-40 y and predominantly in female patients (female, male ratio 1.9:1).General wards contributed to 54.9% of the Acinetobacter infection, followed by ICU(27%) and OPD(18%). Maximum isolates were recovered from urine(34.4%) and endotracheal secretions(29.5%).60.7% of the Acinetobacterspp were multidrug-resistant(MDR)i.e. resistant to more than 3 antibiotic group.In our study, most Acinetobactersppwere resistant to penicillin(46-100%), third and fourth generation cephalosporin (36-61.5%), carbapenems (34.4-82.8%)and quinolones(39.3-46.7%). None of the isolates were resistant to colistin. 93.4% ofisolates were sensitive to tigecycline and 87.7% sensitive to amikacin.
Conclusion: Our study observed a high incidence of MDR inAcinetobacterspp, which is in line with most of the research findings in recent times. Most of Acinetobacterspp were resistant to penicillin, third and fourth generation cephalosporins, quinolones, carbapenems,which is alarming as it leaves fewer options for the line of treatment. Some strains were sensitive to cefepime, ceftazidime, piperacillin-tazobactam, levofloxacin, imipenem and meropenem. Considering the increasing MDR nature of Acinetobacterspp a combination of the former along with colistin, tigecycline, amikacin(which have shown more than 85% sensitivity) would need to be studied.Also, strict measures to control the spread of Acinetobacter infection, better management of antibiotics usage and newer therapeutic option for treatment need to be looked at.
COMPARISON OF ANTIBACTERIAL ACTIVITY OF HONEY AGAINST AEROBIC AND ANAEROBIC BACTERIA
Authors: DHANARAJ S. , UMAMAGESWARI S. S. M. , MALAVIKA M. , BHUVANESHWARI G. 
Published: January 2021

Objective: To compare the antibacterial activity of honey against aerobic and anaerobic bacteria.
Methods: Honey is extracted from the honey comb by trained persons. Antimicrobial activity of honey is performed by Agar Cup Diffusion technique for 3 bacteria Staphylococcus aureus, E. coli and Clostridium perfringens.
Results: By performing the technique with proper guidance, it is observed that the Staphylococcus aureus specimen shows sensitivity to honey whereas the other two specimens Escherichia coli and clostridium perfringens doesn’t show any sensitivity to honey.
Conclusion: Due to its vast antibacterial activity of honey, it can be used along with other antibiotics to increase its efficiency.
PHARMACOKINETIC STUDY OF OLOPATADINE 10 MG EXTENDED RELEASE TABLET IN COMPARISON WITH OLOPATADINE 5 MG IMMEDIATE RELEASE TABLET IN INDIAN POPULATION
Authors: HUSAIN SAIYED ZEYAUL ABRAR , KHUROO ARSHAD , MARWAH AMIT , VOHORA DIVYA 
Published: January 2021

Objective: This study was designed to assess the pharmacokinetics of single dose of olopatadine hydrochloride 10 mg extended release (ER) tablet of Ranbaxy laboratories limited (two test formulations) with two doses of Allelock® 5 mg immediate release (IR) tablets of Kyowa Hakko Kogyo Co. Ltd. (reference formulation R), in healthy, adult, Indian male subjects under fed condition.
Methods: Fifteen healthy male volunteers, 26.07±6.62 y in age and 57.17±6.68 kg in body weight, were divided into three groups and received either olopatadine hydrochloride 10 mg ER tablet or two doses of Allelock® 5 mg tablets in each period. Blood samples were taken at predetermined time points and plasma concentrations of olopatadine were monitored by liquid chromatography mass spectrometric (LCMS/MS). Pharmacokinetic (PK) parameters AUC0-t, AUC0-24, AUC0-∞, and Cmax were calculated for olopatadine using WinNonlin. A statistical analysis was performed on PK data using SAS system.
Results: The ER formulations showed a similar AUC as compared to the IR formulation and there was no statistically significant difference in AUC of test formulation A and B and reference R. The ratios of AUC0-t, AUC0-24 and AUC0-∞ for A/R were 91.08, 94.90 and 91.32 and for B/R were 89.63, 93.95 and 89.63 respectively. The ER formulations reported a higher Cmax value as compared to IR formulation. The ratios of Cmax for A/R and B/R were 151.09 and 167.96 respectively. But these higher Cmax values did not pose any safety issue as there were no serious adverse events reported during the study.
Conclusion: In conclusion, we can say that though the study drugs did not meet the bioequivalence criteria set by regulatory agencies, but this study gave an insight about PK properties of olopatadine extended release formulation and given an idea about effect of smoking on the PK profile of olopatadine which can be studied in future.
CONSISE SYNTHESIS AND POTENTIAL ANTI-ANGIOGENIC ACTIVITY OF N-1 SUBSTITUTED INDOLYLCHALCONE HYBRIDS ON CHORIOALLANTOIC MEMBRANE (CAM) ASSAY
Authors: WANEGAONKAR ANJALI M. , BHITRE MILIND J. , ZAVERI DILLIP , BAIRAGI SHRIRAM H. 
Published: January 2021

Objective: Synthesis of N-1 Substituted Indolylchalcone Hybrids and evaluation of anti-angiogenic activity using Chorioallantoic Membrane (CAM) Assay.
Methods: Claisen-schmidt reaction is used for the synthesis of 30 Indolylchalcone hybrids, it involves condensation of N-1 substituted indole-3-carboxaldehyde and N1 substituted 2-acetyl-benzimidazole. The phase transfer catalyst, a green catalyst such as anhydrous potassium carbonate (K2CO3) and PEG-400 are used in the alkylation and arylation. All synthesized indolylchalcone hybrids were evaluated for their antiangiogenic activity by in vivo-chorioallantoic membrane (CAM) assay method.
Results: The synthesized indolylchalcone compounds are evaluated. The morphometric study was carried out as described by Melkonian et al. (2002). The Compounds with code C-2, I-1, I-2 are showing the more potent effect on the dose-dependent assay of CAM. The compounds with code C-1, C-3, E-1 to E-3, M-1 and M-5 shows the significant activity, however, though the compounds with code B-1, B-2, CL-1 and A-5 were showing antiangiogenic effect at 0.1 µM, but does not show any significant activity on dose-dependent assay of CAM.
Conclusion: The synthesized Indolylchalcones as shown in the graph possess very good dose-dependent anti-angiogenic activities. The potency of anti-angiogenetic activity shows that methyl>Ethyl>Cl-benzyl>Benzyl>Isobutyl. 2-acetyl benzimidazole analogs have possible future scope to develop as potent angiogenesis inhibitors.
Análisis comparativo de los modelos de creación de laboratorios virtuales de la Universidad Politécnica de Madrid (UPM) y la Universidad Estatal a Distancia (UNED)
Authors: Aguilera Jinesta Roy , Vázquez Pérez Yuri 
Published: January 2021

En el siguiente artículo se expone una comparación de los procesos de elaboración de laboratorios virtuales de la Universidad Politécnica de Madrid (UPM) y de la Universidad Estatal a Distancia de Costa Rica (UNED). El análisis comparativo se basó en la observación y estudio de los procesos de creación de laboratorios virtuales tanto en la UPM como en la UNED.
Además, se realizaron entrevistas a los actores técnicos y académicos involucrados en los procesos de laboratorios virtuales de ambas universidades. Para la comparación se consideran aspectos tales como: definición de laboratorio virtual, proceso de elaboración, alcance y acceso, sistemas informáticos y bases de datos vinculados al laboratorio, repositorio y el modelo teórico.
Dentro de los resultados de la comparación se determina que los procesos de creación de los laboratorios tienen un componente administrativo más definido en la UNED que en la UPM, así como la cantidad de involucrados y trámites es mayor en la UNED que en la UPM.
Otro hallazgo es la diferencia en la integración de los laboratorios, en el caso de la UNED se cuenta con un repositorio en su sitio web, mientras que en la UPM se generó una interfaz que simula el campus universitario y el usuario debe desplazarse en ese mundo virtual para acceder al laboratorio.
En cuanto al uso de los laboratorios, también se encontraron diferencias, en la UNED estas herramientas educativas se emplean para que los estudiantes practiquen, pero no forman parte de una evaluación sumativa, es decir, no tienen valor en la nota final de la asignatura (curso), mientras que, en la UPM, algunos laboratorios de emplean en las clases presenciales para evaluar a los estudiantes.
Incorporating Data Analytics in a Technical Tax Setting: A Case Using Excel and Tableau to Examine a Firm's Schedule M-3 and Tax Risk
Authors: Laplante Stacie K. , Vernon Mary E. 
Published: January 2021

ABSTRACT
New tax accountants are expected to possess strong technical tax and data analytic skills. This case provides an opportunity to improve students' corporate tax and accounting for income taxes knowledge and experience with professional tax workpapers. It also provides exposure to two powerful data analytic platforms, Tableau and Excel. Students must complete a set of tax workpapers, including a Schedule M-3 reconciliation. Students begin to view tax through an analytical mindset, gaining familiarity with descriptive data for tax analyses. This case helps students calculate GAAP and cash effective tax rates, taxable income, temporary and permanent book-tax differences, and formulate a professional written communication. Students also complete tax workpapers; benchmark tax data across time and industry peers; clean, format, and combine data using Excel and Tableau; analyze and visualize data using Tableau; and access and use the IRS's SOI database.
JEL Classification: H29; D89; A22; A23.