bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Demographic Profiles of Children Presenting with Acetaminophen Induced Acute Liver Failure in a Tertiary Paediatric Intensive Care Unit of South India
Authors: Amatya Puja , Kapalavai Sudeep Kumar , Krupanandan Ravi Kumar , Sadasivam Kalaimaran , Sankaranarayanan Srinivas , Ramachandran Bala 
Published: May 2021

Introduction: Acetaminophen (APAP) is the most widely used over-the-counter antipyretic and analgesic medicine in children. Although hepatic failure and death is rare in paediatric population, it is one of the most important and dangerous presentation of acetaminophen induced toxicity in children. There is very sparse data regarding APAP induced paediatric acute liver failure in our settings, hence this study was done to know the clinical and demographic profiles as well as outcome of children with APAP induced acute liver failure.
Methods: This was a retrospective study done in children aged 0 - 18 years admitted with the diagnosis of acetaminophen induced acute liver failure in a tertiary paediatric intensive care unit of South India from January 2014 to December 2018. The clinical, demographic profiles and outcome of these patients were reviewed and analysed.
Results: A total of 26 children had acetaminophen induced acute liver failure. Out of 26 patients, 53.8% were males and 46.1% were females. Among these, 24 (92.3%) survived and two (7.7%) died. The average dose of acetaminophen ingested was 168.5 mg/ kg/d. The mean serum acetaminophen level was 52.3 mg/dl. The presence of low pH, hypotension and international normalised ratio (INR) value of > 4 showed bad outcome in children with acetaminophen induced acute liver failure.
Conclusion: Paracetamol induced acute liver failure is rare but fatal presentation in children. Children with acidosis, shock and INR value of > 4 had poor prognosis. Hence, judicious use of different preparations as well as counselling to parents regarding use of appropriate doses in children should be done while prescribing this medicine.
Efficacy of Heel Warming on Pain Response to Heel Stick in Neonates
Authors: Sharma Sapkota Pratima , Bhandari Sunita Shah , Karn Basanta Kumar , Yadhav Upendra 
Published: May 2021

Introduction: Heel prick is one of the commonest procedures carried out in the hospitalised newborns. Pain is a subjective experience for which the neonates, infants and children respond with behavioural reactions. Applying hot pack to the skin surface causes proximal blood vessels to dilate due to the raised temperature which may decrease the pain perception in neonates. We intended to study the effect of heel warming during heel prick in perception of pain in neonates.
Method: An experimental study was conducted among neonates admitted in paediatric wards of BPKIHS. Total 92 participants undergoing heel prick/stick were selected by consecutive sampling technique and allocated randomly to experimental group and control group. Warmer was applied to the heel of the baby for three to five minutes which provided the baby’s heel with the warmth of 38°C to 40°C prior to heel stick in experimental group only. Newborn’s pain level was assessed in both experimental and control group through The Neonatal Infant Pain Scale (NIPS). Mann Whitney test was used to compare means of pain score between experimental and control groups.
Results: The mean pain score among experimental group was 1.39 and in control group was 2.20. Experimental group showed significantly lower pain (p < 0.001) compared to the control group. Application of warmth before heel stick caused reduction in pain.
Conclusions: The findings suggest that heat application prior to heel stick is effective in reducing pain in newborns.
Referrals from Paediatric Department with Respiratory Symptoms having Skin Lesions
Authors: Jha Sagar Mani , Budhathoki Lee , Shakya Nabin Bhakta , Shakya Sunil , Roka Kumar 
Published: May 2021

Introduction: Paediatric patients with respiratory symptoms having skin lesions are often referred from Paediatric to Dermatology Department. Knowledge about skin and respiratory manifestations will lead to early diagnosis and proper management by the doctors of both the specialties. These dermatological conditions may or may not be related to respiratory illness or may hence be part of total disease process or may be completely separate entity. The aim of this study was to find out skin manifestations of various respiratory diseases and analyse dermatological disorders in children referred from Paediatric Department having respiratory symptoms.
Methods: An observational cross sectional hospital based study involving inpatients and outpatients referred from Paediatrics to Dermatology Department having respiratory illness and skin lesions was undertaken between January 2019 to December 2020. Details of skin disease were recorded. The descriptive statistical analysis was expressed in frequency and percentage and Chi square test was applied to determine significance among variables.
Results: Total 437 patients were included in the study. The most common diagnosis made by Paediatric {160 (36.6%)} and Dermatology Departments {246 (56.2%) was viral exanthema followed by atopic dermatitis {77 (17.6%)}. Out of total 65 patients who suffered from bronchial asthma, 59 (90.7%) patients had atopic dermatitis.
Conclusions: Significant paediatric patients with respiratory illnesses have concomitant skin lesions. There is very high percentage of patients having atopic dermatitis among those who had asthma and hence clearly depicts relation between the two diseases.
RANCANG BANGUN PROTOTIPE KULKAS BERBASIS INTERNET OF THINGS (IoT)
Authors: Surya Agung , Winardi Slamet 
Published: May 2021

Various innovations have been developed in various sectors in industry, especially in the field of technology, one of which is the IoT (Internet of things) technology. The working principle of IOT is to control and monitor object equipped with sensors and connected to network that can later send data and even be able to communicate with other objects. One example is built prototype IOT-based refrigerator. The purpose of this study is to control the use of food ingredients (in the form of eggs and yakult) remotely. During this time users such as egg shops and yakult only receive the results sales and purchases of goods that have been made by employees, often the results of reports that are made are not in accordance with reality in the field. With these problems the authors make design of controller using the refrigerator (eggs and yakult) using the ESP8266 microcontroller, DHT11 to measure temperature, Limit Switch is used for the process of opening and closing the valve. From the results of this research, the results are able to provide information to users in real-time, where users can find out how many items (eggs and yakult) are available in the refrigerator through an application.
POWER OF INNOVATION ON PERFORMANCE AND SOCIO-ENVIRONMENTAL SUSTAINABILITY
Authors: Mazzioni Sady , Magro Cristian Baú Dal , Picolo Jaime Dagostim , Johann Gabriela Bertoletti 
Published: May 2021

Purpose: This study has analyzed the relationship between process and organizational innovation, performance in product, market and technical innovation and social environmental sustainability.
Design/methodology/approach: The data was collected in industrial companies using a questionnaire with a Likert scale and a structural equation model was used to estimate the parameters.
Findings: The results indicated that process and organizational innovation mediated by performance in product, market and technical innovation, influence social and environmental sustainability.
Practical implications: According to the investigated managers, the practical contributions point to the need of considering innovation elements to achieve a good performance. Subsequently points out that better performing organizations favor practices to seek the global sustainability of the enterprises.
Originality/value: The model used in this study, is broader than that applied in previous studies when considering the dimensions of innovation, performance and sustainability concurrently. Thus, it suggests the understanding, by the interested parties, about organizational performance as an influence of good socio-environmental sustainability practices.
Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile spine and sacrum
Authors: Pennington Zach , Ehresman Jeff , Elsamadicy Aladine A. , Shin John H. , Goodwin C. Rory , Schwab Joseph H. , Sciubba Daniel M. 
Published: May 2021

OBJECTIVE
Long-term local control in patients with primary chordoma and sarcoma of the spine and sacrum is increasingly reliant upon en bloc resection with negative margins. At many institutions, adjuvant radiation is recommended; definitive radiation is also recommended for the treatment of unresectable tumors. Because of the high off-target radiation toxicities associated with conventional radiotherapy, there has been growing interest in the use of proton and heavy-ion therapies. The aim of this study was to systematically review the literature regarding these therapies.

METHODS
The PubMed, OVID, Embase, and Web of Science databases were queried for articles describing the use of proton, combined proton/photon, or heavy-ion therapies for adjuvant or definitive radiotherapy in patients with primary sarcoma or chordoma of the mobile spine and sacrum. A qualitative synthesis of the results was performed, focusing on overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), and disease-specific survival (DSS); local control; and postradiation toxicities.

RESULTS
Of 595 unique articles, 64 underwent full-text screening and 38 were included in the final synthesis. All studies were level III or IV evidence with a high risk of bias; there was also significant overlap in the reported populations, with six centers accounting for roughly three-fourths of all reports. Five-year therapy outcomes were as follows: proton-only therapies, OS 67%–82%, PFS 31%–57%, and DFS 52%–62%; metastases occurred in 17%–18% and acute toxicities in 3%–100% of cases; combined proton/photon therapy, local control 62%–85%, OS 78%–87%, PFS 90%, and DFS 61%–72%; metastases occurred in 12%–14% and acute toxicities in 84%–100% of cases; and carbon ion therapy, local control 53%–100%, OS 52%–86%, PFS (only reported for 3 years) 48%–76%, and DFS 50%–53%; metastases occurred in 2%–39% and acute toxicities in 26%–48%. There were no studies directly comparing outcomes between photon and charged-particle therapies or comparing outcomes between radiation and surgical groups.

CONCLUSIONS
The current evidence for charged-particle therapies in the management of sarcomas of the spine and sacrum is limited. Preliminary evidence suggests that with these therapies local control and OS at 5 years are comparable among various charged-particle options and may be similar between those treated with definitive charged-particle therapy and historical surgical cohorts. Further research directly comparing charged-particle and photon-based therapies is necessary.
Surgical management of spinal metastases involving the cervicothoracic junction: results of a multicenter, European observational study
Authors: Hubertus Vanessa , Gempt Jens , Mariño Michelle , Sommer Björn , Eicker Sven O. , Stangenberg Martin , Dreimann Marc , Janssen Insa , Wipplinger Christoph , Wagner Arthur , Lange Nicole , Jörger Ann-Kathrin , Czabanka Marcus , Rohde Veit , Schaller Karl , Thomé Claudius , Vajkoczy Peter , Onken Julia S. , Meyer Bernhard 
Published: May 2021

OBJECTIVE
Surgical management of spinal metastases at the cervicothoracic junction (CTJ) is highly complex and relies on case-based decision-making. The aim of this multicentric study was to describe surgical procedures for metastases at the CTJ and provide guidance for clinical and surgical management.

METHODS
Patients eligible for this study were those with metastases at the CTJ (C7–T2) who had been consecutively treated in 2005–2019 at 7 academic institutions across Europe. The Spine Instability Neoplastic Score, neurological function, clinical status, medical history, and surgical data for each patient were retrospectively assessed. Patients were divided into four surgical groups: 1) posterior decompression only, 2) posterior decompression and fusion, 3) anterior corpectomy and fusion, and 4) anterior corpectomy and 360° fusion. Endpoints were complications, surgical revision rate, and survival.

RESULTS
Among the 238 patients eligible for inclusion this study, 37 were included in group 1 (15%), 127 in group 2 (53%), 18 in group 3 (8%), and 56 in group 4 (24%). Mechanical pain was the predominant symptom (79%, 189 patients). Surgical complications occurred in 16% (group 1), 20% (group 2), 11% (group 3), and 18% (group 4). Of these, hardware failure (HwF) occurred in 18% and led to surgical revision in 7 of 8 cases. The overall complication rate was 34%. In-hospital mortality was 5%.

CONCLUSIONS
Posterior fusion and decompression was the most frequently used technique. Care should be taken to choose instrumentation techniques that offer the highest possible biomechanical load-bearing capacity to avoid HwF. Since the overall complication rate is high, the prevention of in-hospital complications seems crucial to reduce in-hospital mortality.
Delayed variations in the diagnostic accuracy of intraoperative neuromonitoring in the resection of intramedullary spinal cord tumors
Authors: Kimchi Gil , Knoller Nachshon , Korn Akiva , Eyal-Mazuz Yahel , Sapir Yechiam , Peled Anton , Harel Ran 
Published: May 2021

OBJECTIVE
The use of intraoperative neuromonitoring (IONM) has become an imperative adjunct to the resection of intramedullary spinal cord tumors (IMSCTs). While the diagnostic utility of IONM during the immediate postoperative period has been previously studied, its long-term diagnostic accuracy has seldom been thoroughly assessed. The aim of this study was to evaluate long-term variations in the diagnostic accuracy of transcranial motor evoked potentials (tcMEPs), somatosensory evoked potentials (SSEPs), and D-wave recordings during IMSCT excision.

METHODS
The authors performed a retrospective evaluation of imaging studies, patient charts, operative reports, and IONM recordings of patients who were operated on for gross-total or subtotal resection of IMSCTs at a single institution between 2012 and 2018. Variations in the specificity, sensitivity, positive predictive value (PPV), and negative predictive value (NPV) for postoperative functional outcome (McCormick Scale) were analyzed at postoperative day 1 (POD1), 6 weeks postoperatively (PO-6 weeks), and at the latest follow-up.

RESULTS
Overall, 28 patients were included. The mean length of follow-up was 19 ± 23.4 months. Persistent motor attenuations occurred in 71.4% of the cohort. MEP was the most sensitive modality (78.6%, 87.5%, and 85.7% sensitivity at POD1, PO-6 weeks, and last follow-up, respectively). The specificity of the D-wave was the most consistent over time (100%, 83.35%, and 90% specificity at the aforementioned time points). The PPV of motor recordings decreased over time (58% vs 33% and 100% vs 0 for tcMEP and D-wave at POD1 and last follow-up, respectively), while their NPV consistently increased (67% vs 89% and 70% vs 100% for tcMEP and D-wave at POD1 and last follow-up, respectively).

CONCLUSIONS
The diagnostic accuracy of IONM in the resection of IMSCTs varies during the postoperative period. The decrease in the PPV of motor recordings over time suggests that this method is more predictive of short-term rather than long-term neurological deficits. The increasing NPV of motor recordings indicates a higher diagnostic accuracy in the identification of patients who preserve neurological function, albeit with an increased proportion of false-negative alarms for the immediate postoperative period. These variations should be considered in the surgical decision-making process when weighing the risk of resection-associated neurological injury against the implications of incomplete tumor resection.
Feasibility of achieving planned surgical margins in primary spine tumor: a PTRON study
Authors: Dandurand Charlotte , Fisher Charles G. , Rhines Laurence D. , Boriani Stefano , Charest-Morin Raphaële , Gasbarrini Alessandro , Luzzati Alessandro , Reynolds Jeremy J. , Wei Feng , Gokaslan Ziya L. , Bettegowda Chetan , Sciubba Daniel M. , Lazary Aron , Kawahara Norio , Clarke Michelle J. , Rampersaud Y. Raja , Disch Alexander C. , Chou Dean , Shin John H. , Hornicek Francis J. , Laufer IIya , Sahgal Arjun , Dea Nicolas 
Published: May 2021

OBJECTIVE
Oncological resection of primary spine tumors is associated with lower recurrence rates. However, even in the most experienced hands, the execution of a meticulously drafted plan sometimes fails. The objectives of this study were to determine how successful surgical teams are at achieving planned surgical margins and how successful surgeons are in intraoperatively assessing tumor margins. The secondary objective was to identify factors associated with successful execution of planned resection.

METHODS
The Primary Tumor Research and Outcomes Network (PTRON) is a multicenter international prospective registry for the management of primary tumors of the spine. Using this registry, the authors compared 1) the planned surgical margin and 2) the intraoperative assessment of the margin by the surgeon with the postoperative assessment of the margin by the pathologist. Univariate analysis was used to assess whether factors such as histology, size, location, previous radiotherapy, and revision surgery were associated with successful execution of the planned margins.

RESULTS
Three hundred patients were included. The surgical plan was successfully achieved in 224 (74.7%) patients. The surgeon correctly assessed the intraoperative margins, as reported in the final assessment by the pathologist, in 239 (79.7%) patients. On univariate analysis, no factor had a statistically significant influence on successful achievement of planned margins.

CONCLUSIONS
In high-volume cancer centers around the world, planned surgical margins can be achieved in approximately 75% of cases. The morbidity of the proposed intervention must be balanced with the expected success rate in order to optimize patient management and surgical decision-making.
Prevalence of COVID-19 Positive Cases Diagnosed by Real time Polymerase Chain Reaction in a Tertiary Care Hospital of Nepal
Authors: Pokharel Khilasa , Mishra Bhavesh , Karki Anup 
Published: May 2021

Introduction: The virus that causes COVID-19 is known as severe acute respiratory syndrome Coronavirus-2. This new variant of Corona Virus introduced in China has urged the massive health system resources to focus on its screening and management of sick patients worldwide. We aimed to find the prevalence of COVID-19 positive cases diagnosed by Real-time polymerase chain reaction in a tertiary care hospital of Nepal.
Methods: This is a descriptive cross-sectional study that was conducted from 11th of November to 15th December 2020. Nasopharyngeal and Oropharyngeal swabs were collected, and confirmation of cases of COVID-19 was done based on the detection of viral ribonucleic acid by nucleic acid amplification tests such as real-time reverse transcriptase-polymerase chain reactions. The viral genes targeted include the E, N, and ORF.
Results: A total of 15247 samples have been processed, of which s (14.81%) positive cases were included in this study. There were 1427 (63.19%) male and 831 (36.68%) females. The majority of the cases were asymptomatic 1386 (61.38%). The most common age group infected was between 15 to 40 years, 841 (58.93%) male and 542 (65.22%) females. The most common presenting symptoms were cough 315 (13.95%) and fever 306 (13.55%).
Conclusions: Most of the individuals reported for real-time polymerase chain reaction were asymptomatic patients who might be contagious and have the potential to transmit infection. Among symptomatic cases, common symptoms were cough and fever.
PELATIHAN JOURNALISME WARGA: PENGEMBANGAN MEDIA SOSIAL BAGI MASYARAKAT
Authors: Wedyawati Nelly , Dharma Yokie Prasetya , Susanti Yudita 
Published: May 2021

ABSTRAKPengabdian bertujuan untuk media penyampaian informasi terkait tentang literasi teknologi bagi masyarakat. Hal ini sangat penting selain untuk meningkatkan pemahaman masyarakat terhadap internet sehat, kegiatan ini juga berupaya untuk meningkatkan kepekaan dan antusiasme masyarakat terhadap masalah-masalah yang kerap muncul pada pelayanan publik. Kegiatan dilaksanakan di Desa Nanga Tikan, Kecamatan Kayan Hilir, Kabupaten Sintang, Kalimantan Barat. Sasaran kegiatan PkM ini adalah para perangkat desa dan anggota Karang Taruna (pemuda) yang ada di Desa. Penentuan kriteria khalayak tersebut berdasarkan pengamatan bahwa generasi muda rentang dari umur 17 hingga 35 tahun adalah mereka yang gemar atau secara intensif memanfatkan internet atau sosial media. Bentuk PkM ini penyuluhan dan pelatihan kepada masyarakat tentang pengembangan media sosial. Penyuluhan dan pelatihan dilaksanakan pada tanggal 23 Oktober 2020 di Balai Desa Nanga Tikan dengan model ceramah dan demonstrasi pemanfaatan media sosial (internet). Hasil wawancara dengan kepala desa dan beberapa pemuda desa diperoleh respon sangat baik terhadap kegiatan ini. Hasil angket respon diperoleh hasil 95% dengan kategori sangat senang. Kesimpulan dari kegiatan yaitu sasaran kegiatan sangat puas terhadap pelatihan Journalis warga.Kata Kunci: Pelatihan, Journalis, Literasi, Teknologi, Media. ABSTRACTThe community service aimed to delivering information media related to technology literacy for the community. This is very important in addition to increasing public understanding of a good internet usage, this activity also seeks to increase the sensitivity and enthusiasm of the community towards problems that often arise in public services. The activity was carried out in Nanga Tikan Village, Kayan Hilir District, Sintang District, West Kalimantan. The targets of this PkM activity are village officials and members of the Karang Taruna (youth) in the village.The determination of the audience criteria is based on the observation that the younger generation, ranging from 17 to 35 year old, are those who like or intensively use the internet or social media. This form of PkM provides counseling and training to the community on social media development. Counseling and training was carried out on October 23, 2020 at the Nanga Tikan Village Hall with a lecture and demonstration model of the use of social media (internet). The results of interviews with the village head and several village youth received very good responses to this activity. The results of the response questionnaire were 95% with the very enthusiastic. The conclusion of the activity is that the target of the activity is very satisfied with the citizen journalism training.Keywords: Training, Journalists, Literacy, Technology, Media.