bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vestibular Dysfunction and Gross Motor Milestone Acquisition in Children With Hearing Loss: A Systematic Review
Authors: Singh Anisha , Raynor Eileen M. , Lee Janet W. , Smith Sherri L. , Heet Hannah , Garrison Doug , Wrigley Jordan , Kaylie David M. , Riska Kristal M. 
Published: January 2021

ObjectiveTo describe the impact of vestibular dysfunction on gross motor development in children with hearing loss.Data SourcesMEDLINE (PubMed), Embase (Elsevier), Web of Science (Clarivate), and the Cumulative Index of Nursing and Allied Health Literature (EBSCO).Review MethodsA systematic review was reported in concordance with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta‐analyses). Articles on children with hearing loss who underwent at least 1 instrumented measure of vestibular function and had gross motor milestones assessed were included. The Downs and Black checklist was used to assess risk of bias and methodological quality.ResultsEleven articles were included in the systematic review. Three articles stratified quantitative results of gross motor milestone acquisition by severity of vestibular impairment. Over half of studies were case series published within the last 5 years. This systematic review showed that children with hearing loss and severe, bilateral vestibular dysfunction demonstrate delayed gross motor milestones. However, it was difficult to draw conclusions on whether milder forms of vestibular dysfunction significantly affect gross motor milestone acquisition in children with hearing loss. The reason is that most studies were of low to moderate quality, used different assessment methods, and contained results that were descriptive in nature.ConclusionsThis emerging area would benefit from future research, such as higher‐quality studies to assess vestibular function and gross motor milestones. This would allow for better characterization of the impacts of vestibular impairment, especially milder forms, in children with hearing loss.
Kambakutaisoto Treatment for Children With Night Crying and Arousal Parasomnias Developed During Prolonged Hospitalization for Hematological and Oncological Diseases
Authors: Kawashima Nozomu 
Published: January 2021

Objective: The lack of an established treatment standard prompted an examination of whether kambakutaisoto, an herbal formula, is effective for non–rapid eye movement (NREM)–related parasomnias and night crying (provisionally defined as an infantile form of arousal parasomnia). Methods: This study included 137 children aged median 4.1 years (range, 0.02–18.5) who were admitted for hematological and oncological diseases. Results: Of 137, 3 children developed recurrent episodes of NREM-related parasomnias, and 3 developed night crying. The proportion of children with night-crying/parasomnia receiving invasive procedures was significantly higher than those without (100% vs. 47%, P = .013). All 6 children with night crying/parasomnia received kambakutaisoto at a dose of 0.13–0.22 g/kg per os and responded from the start of administration with a significant reduction in the number of episodes. No adverse effects were observed. Conclusion: Kambakutaisoto may be a safe and promising therapy for night crying and NREM-related parasomnias in children.
Circulating nerve growth factor receptor positive cells are associated with severity and prognosis of pulmonary arterial hypertension
Authors: Goten Chiaki , Usui Soichiro , Takashima Shin‐ichiro , Inoue Oto , Okada Hirofumi , Shimojima Masaya , Sakata Kenji , Kawashiri Masaaki , Kaneko Shuichi , Takamura Masayuki 
Published: January 2021

Pulmonary arterial hypertension (PAH) remains a disease with a poor prognosis, so early detection and treatment are very important. Sensitive and non‐invasive markers for PAH are urgently required. This study was performed to identify sensitive markers of the clinical severity and prognosis of PAH. Patients diagnosed with PAH (n = 30) and control participants (n = 15) were enrolled in this observational study. Major EPC and MSC markers (including CD34, CD133, VEGFR2, CD90, PDGFRα, and NGFR) in peripheral blood mononuclear cells (PBMNCs) were assessed by flow cytometry. Associations of these markers with hemodynamic parameters (e.g. mean pulmonary arterial pressure, pulmonary vascular resistance, and cardiac index) were assessed. Patients with PAH were followed up for 12 months to assess the incidence of major adverse events, defined as death or lung transplantation. Levels of circulating EPC and MSC markers in PBMNCs were higher in patients with PAH than in control participants. Among the studied markers, nerve growth factor receptor (NGFR) was significantly positively correlated with hemodynamic parameters. During the 12‐month follow‐up period, major‐event‐free survival was significantly higher in patients with PAH who had relatively low frequencies of NGFR positive cells than patients who had higher frequencies. These results suggested that the presence of circulating NGFR positive cells among PBMNCs may be a novel biomarker for the severity and prognosis of PAH.
Combined antegrade femur lengthening and distal deformity correction: a case series
Authors: Jardaly Achraf , Gilbert Shawn R. 
Published: January 2021

Abstract
Background
Leg length discrepancy is often associated with distal femur angular deformities such as valgus or flexion. This study aims to report a new technique for simultaneous limb lengthening and acute distal femoral angular correction.

Methods
A retrospective chart review of patients undergoing a single procedure was conducted. Patients included had a single operation where they underwent distal femur osteotomy stabilized with a plate followed by antegrade nailing with a magnetically controlled intramedullary lengthening nail (PRECICE, Ellipse Technologies, Inc., Irvine, CA, USA) using a trochanteric entry.

Results
Seven femurs from 7 patients were included. The average age at operation was 13.6 years, and the leg length difference was 51 mm (range 30–105 mm). Associated deformities were valgus (4), knee flexion contracture (2), and both valgus and flexion contracture (1). Lengthening achieved was 43 mm (P = 0.0036), with a consolidation index of 27 days/cm and reliability of 0.87 (6/7). The 5 patients with angulation had an improvement of valgus from 12 to 4° (P = 0.006) and of the mechanical axis deviation from 34 to 3 mm (P = 0.0001). The range of motion also improved in the 3 patients with contractures. Preoperative gait disturbance, hip and knee pain, and functional scoliosis resolved after the limb deformities were corrected.

Conclusion
Combining a magnetic internal lengthening nail with a second distal osteotomy stabilized with a plate can successfully correct limb length and distal femur deformity acutely without altering the expected result of each procedure.
AP2/ERF and R2R3-MYB family transcription factors: potential associations between temperature stress and lipid metabolism in Auxenochlorella protothecoides
Authors: Xing Guanlan , Li Jinyu , Li Wenli , Lam Sin Man , Yuan Hongli , Shui Guanghou , Yang Jinshui 
Published: January 2021

Abstract
Background
Both APETALA2/Ethylene Responsive Factor (AP2/ERF) superfamily and R2R3-MYB family were from one of the largest diverse families of transcription factors (TFs) in plants, and played important roles in plant development and responses to various stresses. However, no systematic analysis of these TFs had been conducted in the green algae A. protothecoides heretofore. Temperature was a critical factor affecting growth and lipid metabolism of A. protothecoides. It also remained largely unknown whether these TFs would respond to temperature stress and be involved in controlling lipid metabolism process.

Results
Hereby, a total of six AP2 TFs, six ERF TFs and six R2R3-MYB TFs were identified and their expression profiles were also analyzed under low-temperature (LT) and high-temperature (HT) stresses. Meanwhile, differential adjustments of lipid pathways were triggered, with enhanced triacylglycerol accumulation. A co-expression network was built between these 18 TFs and 32 lipid-metabolism-related genes, suggesting intrinsic associations between TFs and the regulatory mechanism of lipid metabolism.

Conclusions
This study represented an important first step towards identifying functions and roles of AP2 superfamily and R2R3-MYB family in lipid adjustments and response to temperature stress. These findings would facilitate the biotechnological development in microalgae-based biofuel production and the better understanding of photosynthetic organisms’ adaptive mechanism to temperature stress.
Intestinal obstruction due to small bowel herniation through foramen of Winslow: a case report
Authors: Bandara P. K. B. S. C. , Viraj Rohana A. M. , Pathirana Aloka 
Published: January 2021

Abstract
Background
Intestinal obstruction due to internal herniation of the bowel is a rare clinical entity which is often overlooked in the differential diagnosis of patients with abdominal pain who have no previous history of abdominal surgery. Several sites of bowel internal herniation have been described, amongst which internal herniation through the foramen of Winslow accounts for about 8% of cases. These patients present with nonspecific abdominal pain associated with symptoms of gastroesophageal reflux disease, and hence the diagnosis is often overlooked. The usual symptoms of intestinal obstruction can be delayed, which results in a delay in diagnosis and gangrene of the herniated bowel segment. Abdominal radiographs and computed tomography are helpful in the diagnosis. Open reduction is the management of choice; however, laparoscopic reduction has also been attempted, with good results.

Case presentation
We report a case of a middle-aged Sri Lankan man who presented with features of gastroesophageal reflux disease, developed features of intestinal obstruction and was found to have a gangrenous small bowel loop which had herniated through the foramen of Winslow. Following needle aspiration and reduction of the herniated small bowel loop, the gangrenous part of the small bowel was resected and an ileoileal anastomosis performed. The large foramen of Winslow was partially closed with interrupted stitches. The patient made an uneventful recovery.

Conclusion
Since delayed diagnosis of bowel obstruction is detrimental, it is of utmost importance to diagnose it early. Because internal herniation of the small bowel through the foramen of Winslow presents with nonspecific symptoms including features of gastroesophageal reflux disease, as documented in several cases worldwide and also presented by our patient, there should be a high degree of suspicion of internal herniation of the bowel causing bowel obstruction and low threshold for extensive investigation of patients presenting with symptoms of gastroesophageal reflux disease which does not resolve with usual medication.
Use of chicken feather meal fermented with Bacillus subtilis in diets to increase the digestive enzymes activity and nutrient digestibility of silver pompano Trachinotus blochii (Lacepede, 1801)
Authors: Adelina Adelina , Feliatra Feli , Siregar Yusni Ikhwan , Putra Iskandar , Suharman Indra 
Published: January 2021

Background: Feather has the potential to be used as a fish feed ingredient because it has high protein content (80-85%), and is rich in amino acids arginine, leucine, isoleucine and valine. However, the protein consists mainly of keratin, which is classified as fiber that is difficult to digest. Therefore, to improve digestibility, the keratin protein is degraded using microbial Bacillus subtilis. This study aimed to determine the digestibility of fermented feather meal (FFM) in silver pompano diets and to observe the histological structure of their intestines after digestion. Methods: The method used was a one factor experiment with five treatments and three replications each, which were: diet without FFM (P0), diet containing 10% FFM (P1), 20% (P2), 30% (P3) and 40% (P4). The diets were given to juvenile silver pompano (with average body weight of 8.56 ± 0.18 g) and stocked with 10 fish in a 100 L capacity container. The experimental diets were given three times daily at approximately 8.00 AM, 12.00 PM and 5.00 PM to apparent satiation for 60 days. Results: The results showed that the use of FFM increased the activity of digestive enzymes (protease and lipase), but reduced the amylase activity of silver pompano, which was significantly different between treatments (P <0.05). Meanwhile, the diet containing 20% FFM produced the highest feed and protein, which are 37.05% and 67.24%, respectively. This was significantly different from other treatments (P <0.05), and was effectively absorbed by fish intestines. Conclusion: The addition of chicken feather meal fermented with Bacillus subtilis could increase the activity of digestive enzymes and nutrient digestibility of silver pompano.
Grinding Burns Testing — New NDT Method? Do You Need Qualified Specialists for This?
Authors: Seidel Martin W. , Zösch Antje , Härtel Konstantin , Morgenstern Gunnar 
Published: January 2021

The highly loaded components used in machine building, automotive and aviation must have no thermal damage during grinding, the so-called grinding burn. In less loaded components, the grinding burn shall not exceed a certain level agreed between the manufacturer and the customer.
In industrial practice, etching, Barkhausen-Rausch methods and eddy current are used to detect burns. To reliably perform inspection according to any of the methods, it is necessary that the flaw detection experts have sufficient knowledge and skills. This is particularly relevant for the multi-stage chemical etching process.
In 2015, at the request of Turkish partners, IMQ developed the course "Inspection of grinding burns using chemical etching" in accordance with ISO 14104 and AMS 2649. Since then, more than 70 participants from several European countries have successfully completed this two-day course.
In cooperation with DGZfP Ausbildung und Training GmbH, IMQ has developed a new course for the training of flaw detectors in the burns inspection during grinding. In addition to the etching method, the course included the eddy current method and the Barkhausen method, as well as liquid penetrant testing and magnetic powder testing. The content of the course, practical exercises and elements of the final exam in theory and practice are presented.
Assessing thermal tolerance of vulnerable alpine stream insects as part of a long-term monitoring project in the Teton Range, Wyoming
Authors: Tronstad Lusha M. , Giersch J. Joseph , Hotaling Scott , Finn Debra S. , Zeglin Lydia , Wilmot Oliver J. , Bixby Rebecca J. , Shah Alisha A. , Dillon Michael E. 
Published: January 2021

Alpine streams are predicted to decline as air temperatures warm and their water sources dry. Stream temperatures are expected to increase as glaciers and permanent snowfields decrease in size. For aquatic insects that are cold-adapted and restricted to small, high elevation streams fed by glaciers or snowfields, warmer water temperatures could be lethal. Conversely, less water in streams may increase the likelihood of insects freezing during winter months. We measured the critical thermal maximum (CTMAX) – the highest non-lethal temperature an insect can survive, and supercooling temperature – the temperature at which an insect freezes, of three alpine stoneflies, Zapada sp., Lednia tetonica and Lednia tumana, collected in Grant Teton and Glacier National Parks. CTMAX and supercooling point varied among species and with stream source (glacier-fed, snowmelt-fed and icy seep) and population (seven populations). Supercooling temperature was lowest in an alpine tarn and highest in glacier- and snowmelt-fed streams. Zapada sp. had the lowest CTMAX of the three species. Stoneflies from icy seeps had lower CTMAX than individuals from glacier- or snowmelt-fed streams. Individuals that likely experience the coldest winter temperatures had the lowest supercooling temperature. Similarly, stoneflies that experienced warmer water temperatures also had higher CTMAX values. Investigating the thermal tolerances of alpine stoneflies allows us to predict how these insects may respond to future climate change scenarios.

Featured photo by Nicole Y-C on Unsplash. https://unsplash.com/photos/9XixVlnUCbk
unbekannter Besuch Joseph Haydns auf der Leipziger Thomasschule
Authors: Glöckner Andreas 
Published: January 2021

Der Artikel widmet sich hauptsächlich Thomaskantor Johann Adam Hiller, über dessen Amtszeit ein längerer Nekrolog des Thomasschul-Alumnus Carl Traugott Neumann neben anderem die Besuche berühmter zeitgenössischer Musiker an der Thomasschule verzeichnet, darunter neben W. A. Mozart, Johann Gottlieb Naumann, Johann Freidrich Reichardt und Friedrich Heinrich Himmel eben Joseph Haydn. Daran knüpft der Artikel einige Informationen um die Pflege des Werks Joseph Haydns bei den Thomanern um die Wende des 18. zum 19. Jahrhundert sowie zu den Beziehungen der weiteren erwähnten Musiker nach Leipzig.

Erwähnte Artikel: Ulrich Leisinger: Die "Bachsche Auction" von 1789. BJ 1991, S. 97-126
Incidence, risk factors and impact of seasonal influenza in pregnancy: A national cohort study
Authors: Vousden Nicola , Bunch Kathryn , Knight Marian ,   the UKOSS Influenza Co-Investigators Group
Published: January 2021

Background
Pregnant women are particularly vulnerable to severe infection from influenza resulting in poor neonatal outcomes. The majority of evidence relates to pandemic 2009 A/H1N1 influenza. The objective of this study was to describe the characteristics and outcomes of pregnant women hospitalised with seasonal influenza.

Methods
This national, prospective, observational cohort study used the UK Obstetric Surveillance System (UKOSS) to identify all pregnant women admitted to hospital between 01/11/2016 and 31/10/2018 with laboratory confirmed influenza at any gestation and up to two days after giving birth. These were compared to women admitted to give birth that did not have influenza. Baseline characteristics, immunization status, maternal and perinatal outcomes were compared.

Results
There were 405 women admitted to hospital with laboratory confirmed influenza in pregnancy: 2.7 per 10,000 maternities. Compared to 694 comparison women, women with influenza were less likely to be professionally employed (aOR 0.59, 95%CI 0.39–0.89) or immunised in the relevant season (aOR 0·59, 0·39–0·89) and more likely to have asthma (aOR 2.42, 1.30–4.49) or have had a previous pregnancy complication (aOR 2·47, 1·33–4·61). They were more likely to be admitted to intensive care (aOR 21.3, 2.78–163.1) and to have a cesarean birth (aOR 1·42, 1·02–1.98). Their babies were more likely to be admitted to neonatal intensive care (aOR 1.86, 1·01–3·42).

Conclusions
Immunization reduces the risk of hospitalisation with influenza in pregnancy which is associated with increased risk of morbidity for both the mother and baby. There is a continued need to increase awareness of safety and effectiveness of immunization in pregnancy and provision within antenatal care settings, especially for high-risk groups.
Effect of oral statin use on mitomycin-C augmented trabeculectomy outcomes
Authors: Inobhas Abhibol , Chansangpetch Sunee , Manassakorn Anita , Tantisevi Visanee , Rojanapongpun Prin 
Published: January 2021

Purpose
The effect of statins on wound healing is controversial, and their effect on trabeculectomy outcomes remains unclear. This study aimed to examine the relationship between oral statin use and trabeculectomy outcomes.

Methods
Medical records of patients who underwent primary mitomycin-C augmented trabeculectomy with 2 years of follow-up were reviewed. Pre- and postoperative intraocular pressures (IOP) and numbers of medications, subconjunctival 5-fluorouracil (5-FU) injections, and bleb-needling procedures were compared between statin users and nonusers. Failure was defined as an eye that failed to achieve a 20% lowering of IOP from baseline or had an IOP > 21 mm Hg, as well as an eye that required further surgical intervention, developed hypotony, or had no light perception visual acuity.

Results
In total, 158 subjects were enrolled, with 47 eyes from statin users and 111 eyes from statin nonusers. The 24-month cumulative probability of failure was 78.7% for statin users and 60.4% for nonusers (P = .013). Cox proportional-hazards modeling showed a significantly higher hazard risk in statin users (adjusted hazard ratio 1.61, P = .026). There were no significant between-group differences in mean IOPs or number of medications (both P > .05) at 24 months. Multivariable Poisson regression analysis that statin use was associated with increased numbers of 5-FU injections (P = .014) and bleb-needling procedures (P = .031).

Conclusions
This study demonstrated that oral statin use was associated with higher rates of trabeculectomy failure and increased numbers of 5-FU injections and bleb-needling procedures.
Diagnostic performance evaluation of different TI-RADS using ultrasound computer-aided diagnosis of thyroid nodules: An experience with adjusted settings
Authors: Chambara Nonhlanhla , Liu Shirley Y. W. , Lo Xina , Ying Michael 
Published: January 2021

Background
Thyroid cancer diagnosis has evolved to include computer-aided diagnosis (CAD) approaches to overcome the limitations of human ultrasound feature assessment. This study aimed to evaluate the diagnostic performance of a CAD system in thyroid nodule differentiation using varied settings.

Methods
Ultrasound images of 205 thyroid nodules from 198 patients were analysed in this retrospective study. AmCAD-UT software was used at default settings and 3 adjusted settings to diagnose the nodules. Six risk-stratification systems in the software were used to classify the thyroid nodules: The American Thyroid Association (ATA), American College of Radiology Thyroid Imaging, Reporting, and Data System (ACR-TIRADS), British Thyroid Association (BTA), European Union (EU-TIRADS), Kwak (2011) and the Korean Society of Thyroid Radiology (KSThR). The diagnostic performance of CAD was determined relative to the histopathology and/or cytology diagnosis of each nodule.

Results
At the default setting, EU-TIRADS yielded the highest sensitivity, 82.6% and lowest specificity, 42.1% while the ATA-TIRADS yielded the highest specificity, 66.4%. Kwak had the highest AUROC (0.74) which was comparable to that of ACR, ATA, and KSThR TIRADS (0.72, 0.73, and 0.70 respectively). At a hyperechoic foci setting of 3.5 with other settings at median values; ATA had the best-balanced sensitivity, specificity and good AUROC (70.4%; 67.3% and 0.71 respectively).

Conclusion
The default setting achieved the best diagnostic performance with all TIRADS and was best for maximizing the sensitivity of EU-TIRADS. Adjusting the settings by only reducing the sensitivity to echogenic foci may be most helpful for improving specificity with minimal change in sensitivity.