bluuebunny/crossref_metadata_2025_split huggingface dataset:
No association between dynamic trunk flexion strength and throwing velocity in elite women handball players
Authors: Tomasa Tommy , Østerås Sindre , McGhie David 
Published: May 2021

BACKGROUND: The relationship between strength and throwing velocity is much investigated in handball, but core strength is largely ignored. Only four studies have investigated the effect of core training on handball throwing velocity, reporting conflicting results in amateur players. However, lack of specificity and deficient technical execution of throwing in amateurs can obscure the results. OBJECTIVE: To examine the direct association between trunk flexion strength and throwing velocity in elite handball players, using women as a model. METHODS: Sixteen women players from an elite-level Norwegian handball team participated in the study. Strength in trunk flexion, shoulder extension, internal shoulder rotation, and forearm pronation was assessed using isokinetic dynamometer measurements (peak moment, total work, angular impulse). Throwing velocity in both the standing throw with run-up and the jump throw was determined from motion capture measurements. To account for arm strength, the association between trunk flexion strength and throwing velocity was examined using partial correlation analyses. RESULTS: No significant association was found between any measure of trunk flexion strength and throwing velocity for either throwing technique (explained variance [Formula: see text] 13.7%). CONCLUSIONS: The results indicate that isolated, dynamic trunk flexion strength is not a differentiating factor for handball throwing velocity in elite women players.
Hereditary Transthyretin Amyloidosis- Clinical and Genetic Characteristics of a Multiracial South-East Asian Cohort in Singapore
Authors: Chen Zhiyong , Koh Jasmine S. , Saini Monica , Tay Karine S.S. , Jayne Tan Yi , Chai Josiah Y.H. , Fam Su Rong , Juraidah A.R. , Lim Peck Kee , Ng Adeline S.L. , Prasad Kalpana , Tan Chai Beng , Umapathi T , Verma Kamal K. , Yong Ming Hui , Yu Chen , Ng Peng Soon 
Published: May 2021

Background and aims: Studies of hereditary transthyretin amyloidosis (ATTRv amyloidosis) in South-East Asia are underrepresented in the literature. We report the unique phenotypic and genetic characteristics of this disorder in a multiracial South-East Asian cohort. Methods: Patients with genetically proven ATTRv amyloidosis were identified over a 13-year period (2007–2020) at the National Neuroscience Institute, Singapore. Clinical, laboratory, genotypic and electrophysiological features were retrospectively reviewed. Results: 29 patients comprising Chinese, Malay, Burmese, Vietnamese and Indonesians with ATTRv amyloidosis were identified. Somatic neuropathy was the most common initial presentation, followed by carpal tunnel syndrome, autonomic dysfunction and cardiac dysfunction. ATTR-A97S (p.Ala117Ser) was the most common variant found in 14 patients, constituting 66.7%of ethnic Chinese patients and 48.3%of the entire cohort. Five patients had early-onset disease (age < 50 years) with the following variants: ATTR-V30M (p.Val50Met), ATTR-G47A (p.Gly67Ala), ATTR-S50I (p.Ser70Ile) and ATTR-A97S (p.Ala117Ser); one patient with ATTR-A97S (p.Ala117Ser) had isolated unilateral carpal tunnel syndrome with amyloid deposits identified on histological examination of the transverse carpal ligament. All early-onset patients had a positive parental history; two patients, with ATTR-S50I (p.Ser70Ile) and ATTR-Ala97Ser (p.Ala117Ser) respectively, demonstrated anticipation with mother-to-daughter inheritance. Amongst the 24 patients with late-onset disease (age≥50 years), two patients had novel variants, ATTR-G66D (p.Glu86Asp) and ATTR-A81V (p.Ala101Val) that were confirmed to be pathogenic based on the histological identification of transthyretin amyloid. Other identified variants included ATTR-V30M (p.Val50Met), ATTR-R34T (p.Arg54Thr), ATTR-S50I (p.Ser70Ile), ATTR-H88R (p.His108Arg) and ATTR-A97S (p.Ala117Ser). Conclusion: Our study further expands the genotypic and phenotypic knowledge regarding ATTRv amyloidosis.
Convocatoria 2021 Concurso alumnos de la Cátedra Psicología de la Salud de la UFLO
Authors: Prozzillo Paola , Gómez Oscar R. 
Published: May 2021

La Fundación MenteClara internacional y la Cátedra Psicología de la Salud de la Facultad de Psicología y Ciencias Sociales de la Universidad de Flores, Argentina, convocan nuevamente a la participación de los estudiantes que se encuentran cursando la asignatura a producir artículos de revisión bibliográfica que contemplen en su desarrollo los constructos teóricos nucleares de incumbencia para la Psicología Positiva: bienestar subjetivo, envejecimiento activo, apoyo social, espiritualidad, optimismo, fluir, inteligencia emocional, florecimiento, felicidad, motivación, resiliencia, autoestima, autonomía, propósito en la vida, bienestar, estrategias de afrontamiento, prevención y promoción de la salud.
Radiofrequency Ablation for Cervical Metastatic Lymph Nodes in Children and Adolescents With Papillary Thyroid Carcinoma: A Preliminary Study
Authors: Yan Lin , Zhang Ying , Jiang Bo , Luo Yukun 
Published: May 2021

ObjectiveTo evaluate the safety and efficacy of radiofrequency ablation (RFA) for metastatic lymph nodes (LNs) in children and adolescents with papillary Thyroid Carcinoma (PTC).Materials and MethodsFrom December 2014 to March 2018, 10 metastatic LNs(mean volume 0.30 ± 0.38 ml, range 0.06-1.23ml) in 5 children and adolescents (3 females, 2 males; mean age 15.60 ± 2.97 years, range 12-19 years) with PTC treated by RFA were evaluated in this study. The mean number of surgical procedures performed before RFA was 1.2 (range 1-2) and the mean number of treated metastatic LNs per patient was 2 (rang 1-3). RFA was performed with an 18–gauge bipolar RF applicator under local anesthesia. Follow-up consisted of US and serum thyroglobulin (Tg) level at 1, 3, 6, 12 months and every 12 months thereafter.ResultsAll the patients were well tolerant to RFA procedure and no procedure-related complications occurred. During a mean follow-up time of 52.00 ± 21.44 months, the initial volume of LNs was 0.30 ± 0.38 ml, which significantly decreased to 0.01 ± 0.03 ml (P = 0.005) with a mean VRR of 99.28 ± 2.27%. A total of 9 metastatic LNs (90.00%) completely disappeared. After RFA, 2 patients developed newly metastases. One patient had additional RFA. The other one with multiple LN metastases underwent total thyroidectomy with central neck dissection.ConclusionAs a less invasive and effective technique, RFA may provide another alternative to the existing therapeutic modalities for cervical metastatic LNs in children and adolescents with PTC.
Acute Alcohol Intoxication Modulates Monocyte Subsets and Their Functions in a Time-Dependent Manner in Healthy Volunteers
Authors: Janicova Andrea , Haag Florian , Xu Baolin , Garza Alejandra P. , Dunay Ildiko Rita , Neunaber Claudia , Nowak Aleksander J. , Cavalli Paola , Marzi Ingo , Sturm Ramona , Relja Borna 
Published: May 2021

BackgroundExcessive alcohol intake is associated with adverse immune response-related effects, however, acute and chronic abuse differently modulate monocyte activation. In this study, we have evaluated the phenotypic and functional changes of monocytes in acutely intoxicated healthy volunteers (HV).MethodsTwenty-two HV consumed individually adjusted amounts of alcoholic beverages until reaching a blood alcohol level of 1‰ after 4h (T4). Peripheral blood was withdrawn before and 2h (T2), 4h (T4), 6h (T6), 24h (T24), and 48h (T48) after starting the experiment and stained for CD14, CD16 and TLR4. CD14brightCD16-, CD14brightCD16+ and CD14dimCD16+ monocyte subsets and their TLR4 expression were analyzed by flow cytometry. Inflammasome activation via caspase-1 in CD14+ monocytes was measured upon an ex vivo in vitro LPS stimulation. Systemic IL-1β and adhesion capacity of isolated CD14+ monocytes upon LPS stimulation were evaluated.ResultsThe percentage of CD14+ monocyte did not change following alcohol intoxication, whereas CD14brightCD16- monocyte subset significantly increased at T2 and T24, CD14brightCD16+ at T2, T4 and T6 and CD14dimCD16+ at T4 and T6. The relative fraction of TLR4 expressing CD14+ monocytes as well as the density of TLR4 surface presentation increased at T2 and decreased at T48 significantly. TLR4+CD14+ monocytes were significantly enhanced in all subsets at T2. TLR4 expression significantly decreased in CD14brightCD16- at T48, in CD14brightCD16+ at T24 and T48, increased in CD14dimCD16+ at T2. IL-1β release upon LPS stimulation decreased at T48, correlating with TLR4 receptor expression. Alcohol downregulated inflammasome activation following ex vivo in vitro stimulation with LPS between T2 and T48 vs. T0. The adhesion capacity of CD14+ monocytes decreased from T2 with significance at T4, T6 and T48. Following LPS administration, a significant reduction of adhesion was observed at T4 and T6.ConclusionsAlcohol intoxication immediately redistributes monocyte subsets toward the pro-inflammatory phenotype with their subsequent differentiation into the anti-inflammatory phenotype. This is paralleled by a significant functional depression, suggesting an alcohol-induced time-dependent hyporesponsiveness of monocytes to pathogenic triggers.
Vaccine-Induced Protection in Two Murine Models of Invasive Pulmonary Aspergillosis
Authors: Rayens Emily , Rabacal Whitney , Kang S. Earl , Celia Brandi N. , Momany Michelle , Norris Karen A. 
Published: May 2021

Life-threatening, invasive fungal infections (IFIs) cause over 1.5 million deaths worldwide and are a major public health concern with high mortality rates even with medical treatment. Infections with the opportunistic fungal pathogen, Aspergillus fumigatus are among the most common. Despite the growing clinical need, there are no licensed vaccines for IFIs. Here we evaluated the immunogenicity and protective efficacy of an A. fumigatus recombinant protein vaccine candidate, AF.KEX1, in experimental murine models of drug-induced immunosuppression. Immunization of healthy mice with AF.KEX1 and adjuvant induced a robust immune response. Following AF.KEX1 or sham immunization, mice were immunosuppressed by treatment with either cortisone acetate or hydrocortisone and the calcineurin inhibitor, tacrolimus. To test vaccine efficacy, immunosuppressed mice were intranasally challenged with A. fumigatus conidia (Af293) and weight and body temperature were monitored for 10 days. At study termination, organism burden in the lungs was evaluated by quantitative PCR and Gomori’s methanamine silver staining. In both models of immunosuppression, AF.KEX1 vaccinated mice experienced decreased rates of mortality and significantly lower lung organism burden compared to non-vaccinated controls. The lung fungal burden was inversely correlated with the peak anti-AF.KEX1 IgG titer achieved following vaccination. These studies provide the basis for further evaluation of a novel vaccine strategy to protect individuals at risk of invasive aspergillosis due to immunosuppressive treatments.
Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects
Authors: Verbruggen Lise , Sprimont Lindsay , Bentea Eduard , Janssen Pauline , Gharib Azzedine , Deneyer Lauren , De Pauw Laura , Lara Olaya , Sato Hideyo , Nicaise Charles , Massie Ann 
Published: May 2021

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been performed using the EMA- and FDA-approved drug sulfasalazine (SAS). Even though this molecule is already on the market for decades as an anti-inflammatory drug, serious side effects due to its use have been reported. Whereas for the treatment of the main indications, SAS needs to be cleaved in the intestine into the anti-inflammatory compound mesalazine, it needs to reach the systemic circulation in its intact form to allow inhibition of system xc−. The higher plasma levels of intact SAS (or its metabolites) might induce adverse effects, independent of its action on system xc−. Some of these effects have however been attributed to system xc− inhibition, calling into question the safety of targeting system xc−. In this study we chronically treated system xc− - deficient mice and their wildtype littermates with two different doses of SAS (160 mg/kg twice daily or 320 mg/kg once daily, i.p.) and studied some of the adverse effects that were previously reported. SAS had a negative impact on the survival rate, the body weight, the thermoregulation and/or stress reaction of mice of both genotypes, and thus independent of its inhibitory action on system xc−. While SAS decreased the total distance travelled in the open-field test the first time the mice encountered the test, it did not influence this parameter on the long-term and it did not induce other behavioral changes such as anxiety- or depressive-like behavior. Finally, no major histological abnormalities were observed in the spinal cord. To conclude, we were unable to identify any undesirable system xc−-dependent effect of chronic administration of SAS.
Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
Authors: DeRango-Adem Eva F. , Blay Jonathan 
Published: May 2021

Apigenin (4′, 5, 7-trihydroxyflavone) is a plant flavone that has been found to have various actions against cancer cells. We evaluated available evidence to determine whether it is feasible for apigenin to have such effects in human patients.Apigenin taken orally is systemically absorbed and recirculated by enterohepatic and local intestinal pathways. Its bioavailability is in the region of 30%. Once absorbed from the oral route it reaches maximal circulating concentration (Cmax) after a time (Tmax) of 0.5–2.5h, with an elimination half-life (T1/2) averaging 2.52 ± 0.56h.Using a circulating concentration for efficacy of 1–5μmol/L as the target, we evaluated data from both human and rodent pharmacokinetic studies to determine if a therapeutic concentration would be feasible. We find that oral intake of dietary materials would require heroic ingestion amounts and is not feasible. However, use of supplements of semi-purified apigenin in capsule form could reach target blood levels using amounts that are within the range currently acceptable for other supplements and medications. Modified formulations or parenteral injection are suitable but may not be necessary.Further work with direct studies of pharmacokinetics and clinical outcomes are necessary to fully evaluate whether apigenin will contribute to a useful clinical strategy, but given emerging evidence that it may interact beneficially with chemotherapeutic drugs, this is worthy of emphasis. In addition, more effective access to intestinal tissues from the oral route raises the possibility that apigenin may be of particular relevance to gastrointestinal disorders including colorectal cancer.
Quantification and Trends of Antimicrobial Use in Commercial Broiler Chicken Production in Pakistan
Authors: Umair Muhammad , Tahir Muhammad Farooq , Ullah Riasat Wasee , Ali Jabir , Siddique Naila , Rasheed Ayesha , Akram Muhammad , Zaheer Muhammad Usman , Mohsin Mashkoor 
Published: May 2021

Antimicrobial resistance (AMR) is a global health challenge and antimicrobial use (AMU) in the livestock sector has been considered as one of the contributing factors towards the development of AMR in bacteria. This study summarizes the results of a point prevalence survey conducted to monitor farm-level AMU in commercial broiler chicken farms in Punjab and Khyber Pakhtunkhwa (KPK) provinces of Pakistan. A cross-sectional study was conducted to quantify AMU and to check seasonal variations of AMU in 12 commercial broiler chicken farms (six from each province) during the summer and winter seasons of the year 2020–2021. AMU was recorded using three AMU metrics: kg, mg per population correction unit (mg/PCU), and mg/kg of final flock weight. A total of 22 antimicrobial drugs (348.59 kg) were used for therapeutic or prophylactic purposes in surveyed broiler chicken farms. The total combined AMU for all the broiler chicken farms was 462.57 mg/PCU. The use of most of the antimicrobials increased during winter flocks compared to summer. The top three antimicrobial drugs used during the summer were neomycin (111.39 mg/PCU), doxycycline (91.91 mg/PCU), and tilmicosin (77.22 mg/PCU), whereas doxycycline (196.81 mg/PCU), neomycin (136.74 mg/PCU), and amoxicillin (115.04 mg/PCU) during the winter. Overall, 60% of the antibiotics used in broiler chicken were critically important antimicrobial classes (CIA) for human medicine as characterized by the World Health Organization. Our findings showed high AMU in broiler chicken production and a call for urgent actions to regulate CIA use in food animals in Pakistan. This baseline survey is critical for the design and implementation of a subsequent national level AMU surveys that can include additional farming types, animals’ species, and geographical locations over a longer period of time.
Povidone-Iodine Attenuates Viral Replication in Ocular Cells: Implications for Ocular Transmission of RNA Viruses
Authors: Singh Sneha , Sawant Onkar B. , Mian Shahzad I. , Kumar Ashok 
Published: May 2021

Several RNA viruses, including SARS-CoV-2, can infect or use the eye as an entry portal to cause ocular or systemic diseases. Povidone-Iodine (PVP-I) is routinely used during ocular surgeries and eye banking as a cost-effective disinfectant due to its broad-spectrum antimicrobial activity, including against viruses. However, whether PVP-I can exert antiviral activities in virus-infected cells remains elusive. In this study, using Zika (ZIKV) and Chikungunya (CHIKV) virus infection of human corneal and retinal pigment epithelial cells, we report antiviral mechanisms of PVP-I. Our data showed that PVP-I, even at the lowest concentration (0.01%), drastically reduced viral replication in corneal and retinal cells without causing cellular toxicity. Antiviral effects of PVP-I against ZIKV and CHIKV were mediated by direct viral inactivation, thus attenuating the ability of the virus to infect host cells. Moreover, one-minute PVP-I exposure of infected ocular cells drastically reduced viral replication and the production of infectious progeny virions. Furthermore, viral-induced (CHIKV) expression of inflammatory genes (TNF-α, IL-6, IL-8, and IL1β) were markedly reduced in PVP-I treated corneal epithelial cells. Together, our results demonstrate potent antiviral effects of PVP-I against ZIKV and CHIKV infection of ocular cells. Thus, a low dose of PVP-I can be used during tissue harvesting for corneal transplants to prevent potential transmission of RNA viruses via infected cells.
SPURIOUS REGRESSION ANALYSIS ON TIME SERIES DATA FROM FACTORS AFFECTING INDONESIAN HUMAN DEVELOPMENT INDEXS IN 1990 – 2017
Authors: Barry Rinto Rain , Bernarto Innocentius 
Published: May 2021

In a spurious regression conditions occur linear regression equations that are not stationary on the mean and variance. If the variables are not stationary, there will be cointegration, so it can be concluded that there is a long-term equilibrium relationship between the two research variables and in the short term there is a possibility of an imbalance, so to overcome it in this study using the Error Correction Model. The purpose of this study is to apply a cointegration test to see whether there is a long-term non-equilibrium relationship between the time series between the Human Development Index and life expectancy at birth, average school year for adults aged 25 years and over and gross national income per capita. The data used in this study are time series data between 1990-2017. The statistical management is carried out using Eviews 10. Based on the results obtained, it was concluded that 81.7% and it can be said that the types of independent variables included in the model are already good, because only 18.3% of the diversity of the dependent variable is influenced by the independent variables outside this research model. Keywords: spurious regression, stationary, cointegration, error correction model, equilibrium
Analisis Pengaruh Pengetahuan Produk, Persepsi Manfaat dan Promosi terhadap Minat Penggunaan Uang Elektronik berbasis server
Authors: Arifiyanto Muhammad , Kholidah Nur 
Published: May 2021

Perkembangan teknologi informasi saat ini berkembang sangat pesat. Hal tersebut sangat berdampak pada berbagai bidang, salah satunya pada sistem pembayaran retail yaitu uang elektronik atau e-money Menurut peraturan Bank Indonesia uang eletronik adalah instrumen pembayaran yang diterbitkan atas dasar nilai uang yang disetor terlebih dahulu kepada penerbit dan nilai uang disimpan secara elektronik dalam suatu media server atau chip. Penelitian ini bertujuan untuk menganalisis pengaruh pengetahuan produk, persepsi manfaat dan promosi terhadap minat penggunaan uang elekronik berbasis server. Responden dari penelitian ini adalah mahasiswa Fakultas Ekonomika dan Bisnis Universitas Muhammadiyah Pekajangan Pekalongan dari program studi akuntansi, ekonomi syariah dan manajemen. Metode sampling yang digunakan adalah purposive sampling dengan total sample 183 responden. Pengumpulan data dilakukan dengan menyebarkan kuesioner yang berisi pertanyaan terbuka dan tertutup. Data yang terkumpul dianalisis dengan menggunakan berbagai uji antara lain uji validitas, uji reliabilitas, uji normalitas, uji multikolinieritas, regresi linear dan uji hipotesis. Hasil penelitian menunjukkan bahwa semua variabel yang diujikan memiliki nilai koefisien positif. Variabel persepsi manfaat memiliki pengaruh tertinggi pada minat penggunaan dengan nilai koefisien 0,722. Selanjutnya variabel promosi memiliki pengaruh terhadap minat penggunaan uang elektronik dengan nilai koefisien 0,367. Dan variabel pengetahuan produk memiliki nilai pengaruh yang paling rendah terhadap minat penggunaan uang elektronik dengan nilai koefisien 0,204.
Not wanted on the voyage: highlighting intrinsic CanMEDS gaps in Competence by Design curricula
Authors: Binnendyk Joan , Pack Rachael , Field Emily , Watling Chris 
Published: May 2021

Background: As governing bodies design new curricula that seek to further incorporate principles of competency-based medical education within time-based models of training, questions have been raised regarding the continued centrality of existing CanMEDS competencies. Although efforts have been made to align these new curricula with CanMEDS, we don’t yet know to what extent these competencies are meaningfully integrated.
Methods: A content analysis approach was used to systematically evaluate national Canadian curricula for 18 residency-training programs and determine the number of times each enabling CanMEDS competency was represented.
Results: Clear trends persisted across all programs. Medical Expert and Collaborator competencies were well integrated into curriculum (81% and 86% mapped to assessment) while competencies related to the Leader, Professional, and Health Advocate roles were less frequently mapped to assessment (41%, 36%, and 40%) and were often absent from the new curricula altogether (59%, 64%, and 60%).
Conclusion: Deliberate planning in curriculum development affords the early identification of gaps. These gaps can inform current assessment practice and future curricular development by providing direction for innovation. If we are to ensure that any new curricula meaningfully address all CanMEDS roles, we need to think carefully about how to best teach and assess underrepresented competencies.