bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial bioenergetics and redox dysfunction in nephrotoxicity induced by pyrethroid permethrin are ameliorated by flavonoid-rich fraction
Authors: Aoiadni Nissaf , Jd Hajer , Feki Abdelfattah El , Fetoui Hamadi , Koubaa Fatma Ghorbel 
Published: May 2021

Abstract
Recent studies suggest that mitochondrial bioenergetics and oxidative status perturbations may be common mechanisms involved in the progression of renal damage. The present study aimed to evaluate in vitro the potential anti-inflammatory using membrane stabilization and protein denaturation inhibition assays and in vivo protective effect of flavonoid- rich fraction from Fumaria officinalis (EAF) against permethrin (PER) induced nephrotoxicity in male rat. Animals were allocated into four groups: control; EAF (200 mg/Kg BW); PER (34.05 mg/Kg BW); and PER (34.05 mg/Kg BW) + EAF (200 mg/Kg BW) for 7 days. Our results suggest that EAF inhibited significantly protein denaturation and restored membrane stabilization. In vivo , permethrin-treated rats caused a substantial reduction of body weight gain and plasma calcium (Ca), phosphorus (P) and vitamin C levels as well as an increase of absolute and relative kidney weights and plasma lactate dehydrogenase (LDH) activity and kidney and mitochondria thiobarbituric acid reactive substance (TBARS), advanced oxidation protein product (AOPP) and protein carbonyl (PCO) levels. PER also caused renal and mitochondrial enzymatic and non-enzymatic antioxidant perturbation as well as mitochondrial NADH-ubiquinone reductase (complex I), ubiquinol cytochrome c reductase (complex III) and cytochrome c oxidase (complex IV) activities reduction associated with renal histopathological alterations. However, co-administration of EAF to the PER group restored oxidative status and mitochondrial bioenergetics. We suggest that EAF may be considered as a future therapeutic anti-inflammatory and may be used singly or as a co-therapeutic in the treatment of diseases associated with mitochondrial oxidative stress.
The effect of Alpha-lipoic acid in glyphosate treated granulosa cells on the human folliculogenesis genes
Authors: Kafshgiri Sakineh Kaboli , Attaranzadeh Armin , Ghasemi Fahimeh , miri-moghaddam Ebrahim 
Published: May 2021

Abstract
Pesticides have a wide range of infertility in female reproductive. GLP is the most common herbicide used worldwide. The present study tended to evaluate the effects of alpha-lipoic acid (ALA) on expression of folliculogenesis genes in human granulosa cells (GCs) treated with glyphosate. In this study, GC samples were taken from infertile male patients who had tubal factors and received ICSI or IVF treatment for the first time. The medium used to culture cells was DMEM-F12 containing FBS 10%, penicillin 1%, and streptomycin 1%. The cells were treated with glyphosate (GLP) (250 µg/ml), ALA (50 µg/ml), and their mixture (250 GLP + 50 ALA) for 24 hr. The FoxO1, NOX4, Vnn1, and STAR gene expression in GCs was determined by real-time PCR. Exposure to GLP decreased gene expression Vnn1 and STAR in the GCs, while in comparison to control group, FOXO1 and NOX4 expression insignificantly increased. Further, ALA treatment decreased FOXO1, NOX4, in the GCs, and increased VNN1 and STAR gene expression. Transcriptional expression of FoxO1, NOX4 and STAR in GCs also decreased in their combinations (GLY + ALA). At the same time, the level of Vnn1 mRNA in GCs was increased. The findings showed that exposure to GLP alters the morphological structure of GCs and the expression of follicogenic genes, leading to dysfunction of the reproductive system. Moreover, the results showed that cell characteristics were preserved efficiently in human GCs exposed to ALA as an antioxidant.
Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy
Authors: Wang Meijian , Xie Min , Yu Shuyan , Shang Pan , Zhang Cong , Han Xiaolin , Fan Cuiqin , Chen Li , Zhuang Xianghua , Chen Shihong 
Published: May 2021

Abstract
Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes, and its exact pathogenesis remains unclear. Autophagy plays an important role in neurodegenerative diseases, ischemia–reperfusion injury of nerve tissues, and nerve tissue injury repair. Lipin1 is a phosphatidic acid phosphatase enzyme that converts phosphatidic acid (PA) into diacylglycerol (DAG), a precursor of triacylglycerol and phospholipids which plays an important role in maintaining normal peripheral nerve conduction function. Here, we show that induction of DPN rat model via STZ injection could reduce Lipin1 expression, prevent DAG synthesis, and results in autophagic hyperactivity. Interestingly, these effects increase the apoptosis of Schwann cells and lead to demyelination in sciatic nerve in DPN rats. More importantly, upregulation of lipin1 in the DPN rats ameliorated autophagy disorders and pathological changes of the sciatic nerve, which associated with the increase of the motor nerve conductive velocity (MNCV) in DPN rats. In contrast, lipin1 downregulation exacerbates neuronal abnormalities and facilitates the genesis of DPN phenotypes in rats. In addition, overexpression of lipin1 in RSC96 cells also significantly decreased the autophagic hyperactivity and apoptosis induced by hyperglycemia. These results suggest that lipin1 may exert neuroprotection within the sciatic nerve anomalies and may serve as a potential therapeutic target for the treatment of DPN.
Interrelationship of Indoor particulate matter and Respiratory dust deposition of women in the residence of Dhanbad City, India
Authors: KUMAR SHRAVAN , Jain Manish Kumar 
Published: May 2021

Abstract
Women spend relatively more time in indoor conditions in developing countries. Exposure to various indoor air pollutants leads them to higher health risks according to Household air quality in which they reside. Particulate matter (PM) exposure with their exposure duration inside the household plays a significant role in women's Respiratory problems. We measured size segregated particulate matter concentrations in 63 residences at different locations. Respiratory dust depositions (RDDs) for 118 women in their different respiratory regions like head-airway (HD), tracheobronchial (TB), and alveolar (AL) region for the three PM size fractions (PM10, PM2.5 & PM1) were investigated. For different positions like Light exercise and the Sitting condition, RDD values found for AL region was 0.091 µgmin− 1 (SD: 0.067, 0.012–0.408) and 0.028 µgmin− 1 (SD: 0.021, 0.003–0.126) for PM10, 0.325 µgmin− 1 (SD: 0.254, 0.053–1.521) and 0.183 µgmin− 1 (SD: 0.143, 0.031–0.857) for PM2.5, 0.257 µgmin− 1 (SD: 0.197, 0.043–1.04) and 0.057 µgmin− 1 (SD: 0.044, 0.009–0.233) respectively for PM1 to females. RDDs values in the AL region significantly increases as PM10 (11%), PM2.5 (68%), and PM1 (21%), confirm that for women, the AL region is the most prominent affected zone by fine particles (PM2.5).
The inducing of caspase and bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats
Authors: Aslan Abdullah , Can Muhammed Ismail , Gok Ozlem , Beyaz Seda , Parlak Gozde , Ozercan Ibrahim Hanifi 
Published: May 2021

Abstract
In this study, 42 Wistar albino female rats (n = 42, 8 weeks old) were used. Rats were divided into 6 groups and 7 rats included each group. Groups: (i) Control Group: Standard diet; (ii) RJ (royal jelly) Group: Standard diet + royal jelly; (iii) F50 Group: Standard diet + 50 mg/kg fluoride; (iv): F100 Group: Standard diet + 100 mg/kg fluoride; (v) F50 + RJ Group: Standard diet + 50 mg/kg fluoride + royal jelly; (iv): F100 + RJ Group: Standard diet + 100 mg/kg fluoride + royal jelly. After the 8-week study period, the rats were decapitated and their muscle tissues were removed. Expression levels of Caspase-3, Caspase-6, Bax, Tnf-α, IL1-α and Bcl-2 proteins in muscle tissue were determined by Western Blotting method. Histopathological analyzes were also performed on the muscle tissue. MDA, GSH, and CAT analyzes were determined by spectrophotometric analysis. According to our findings, Bcl-2, Tnf-α and IL1-α protein expression were increased in damage groups compared to control and royal jelly groups, Caspase-3, Caspase-6 and Bax protein expression levels decreased in damage groups. There was an increase in MDA level in damage groups compared to the control and royal jelly groups, CAT and GSH levels decreased in damage groups. According to histopathological analysis results, edema and inflammatory cell formations were found in the injury groups, a tendency to decrease in these injuries was observed in the treatment groups. Based on these results, we can say that royal jelly has protective effects against fluoride damage.
Adsorption of estrone, 17β-estradiol, and 17α-ethinylestradiol from water onto modified multi-walled carbon nanotubes, carbon cryogel, and carbonized hydrothermal carbon
Authors: Prokic Danijela , Vukčević Marija , Mitrović Angelina , Maletić Marina , Kalijadis Ana , Častvan Ivona Janković , Đurkić Tatjana 
Published: May 2021

Abstract
Carbon materials of different structural and textural properties (multi-walled carbon nanotubes, carbon cryogel, and carbonized hydrothermal carbon) were used as adsorbents for the removal of estrone, 17β-estradiol, and 17α-ethinylestradiol from aqueous solutions. Chemical modification and/or activation were applied to alter surface characteristics and to increase the adsorption and desorption efficiency of carbon materials. Surfaces of treated and untreated carbon materials were characterized through the examination of the textural properties, the nature of surface functional groups, and surface acidity. Although specific surface area and content of surface functional groups did not have a dominant influence on the adsorption process, it was found that a high ratio of surface mesoporosity affected the adsorption process most prominently by increasing adsorption capacity and the rate of the adsorption process. High values of adsorption efficiency (88–100 %) and maximum adsorption capacities (29.45–194.7 mg/g) imply that examined materials, especially mesoporous carbon cryogel and multi-walled carbon nanotubes, can be used as powerful adsorbents for relatively fast removal of estrogen hormones from water.
A case report of a ectopic parathyroid adenoma and literature review
Authors: Liu Xue , Wang lin Hui 
Published: May 2021

Abstract
Background

Giant ectopic mediastinal parathyroid adenoma with cystic degeneration and intratumoral hemorrhage is extremely rare, with low morbidity and a high misdiagnosis rate, and requires precise positioning and surgical resection. Case presentation: A 41-year-old woman presented with a sore throat for 3 days and hoarse voice for 1 day. The following chest computed tomography (CT) showed a large fusiform high-density mass in the posterior tracheal space (maximum cross-section of 34 x 25 mm). ultrasonography of the neck showed a low-echo solid mass. This patient had undergone 2 puncture treatments and 1 surgical treatment from the discovery of the lesion to the diagnosis of the cause over the span of more than a month. Subsequently, the final pathology was definitely diagnosed as parathyroid adenoma with cystic lesions. Six months after the operation, the patient did not relapse.
Conclusions

This case reported a rare and huge ectopic mediastinal parathyroid adenoma that was misdiagnosed as mediastinal tumor hemorrhage at an early stage. For ectopic mediastinal parathyroid adenomas, surgery is the preferred treatment option. Warn us that we should expand the scope of disease thinking for mediastinal tumors.
An Emerging Chemical Fumigant: Two-Sided Effects of Dazomet on Soil Microbial Environment and Plant Response
Authors: Chen Ran , Jiang Weitao , Xu Shaozhuo , Fan Hai , Chen Xuesen , Shen Xiang , Yin Chengmiao , mao zhiquan 
Published: May 2021

Abstract
Methyl bromide has been banned worldwide because it causes damage to the ozone layer and the environment. To find a substitute for methyl bromide, the relationships among fumigation, plant growth, and the microbial community in replant soil require further study. We performed pot and field experiments to investigate the effects of dazomet fumigation on soil properties and plant performance. Changes in soil microbial community structure and diversity were assessed using high-throughput sequencing, and plant physiological performance and soil physicochemical properties were also measured. Dazomet fumigation enhanced photosynthesis and promoted plant growth in replant soil; it altered soil physical and chemical properties and reduced soil enzyme activities, although these parameters gradually recovered over time. After dazomet fumigation, the dominant soil phyla changed, microbial diversity decreased significantly, the relative abundance of biocontrol bacteria such as Mortierella increased, and the relative abundance of pathogenic bacteria such as Fusarium decreased. Over the course of the experiment, the soil microbial flora changed dynamically, and soil enzyme activities and other physical and chemical properties also recovered to a certain extent. This result suggested that the effect of dazomet on soil microorganisms was temporary. However, fumigation also led to an increase in some resistant pathogens, such as Trichosporon, that affect soil function and health. Therefore, it is necessary to consider potential negative impacts of dazomet on the soil environment and to perform active environmental risk management in China.
The Mother with Smeary-Death Life: The Lived Experience of Near Miss Mothers
Authors: Abdollahpour Sedigheh , Heydari Abbas , Ebrahimipour Hosein , Faridhoseini Farhad , Khadivzadeh Talat 
Published: May 2021

Abstract
Background

A Near Miss Mother (NMM) who survives life-threatening conditions, experiences intense physical, emotional, and psychological consequences following the maternal near-miss (MNM) events. The aim of this study was therefore to explore indepth understanding meaning of NMM everyday lived experiences on the social and cultural background of Iran.
Methods

This qualitative study utilized a hermeneutic phenomenology procedure. The study was conducted in hospitals affiliated with the Educational, Research and Treatment Centerwhich usually handle the NMMs. The sampling was purposeful with a maximum variation of eleven NMMs. Datawere collected using unstructured face-to-face interviews, and thetranscribed data were analyzed using Diekelmann, Allen, and Tanner’s seven-stage thematic analysis approach.
Results

"The mother with smeary-death life" was the central emerged theme, and three extracted sub-themes included: "Distorted psyche on a journey to death", "physical destruction due to an ominous event ", and the "vicissitudinous life of the back-to-life mother". These sub-themes, in turn, involved 12 sub-themes that emerged from 38 common meanings and 1200 codes.
Conclusions

Findings demonstrate that NMMs need a supportive program that includes additional follow-up visits, psychological support from the time of hospitalization until long-time after discharge, alleviation of social, sexual, and financial worries to return them to the normal life, as well as psychosocial rehabilitation to increase their life quality. Furthermore, post-discharge care in NMMs should be done actively and directly at their homes.
Chinese Fetal Biometry: Establishment of a Formula for Calculating Gestational Age based on Crown–Rump Length Measurements
Authors: Zhang Yixiu , Meng Hua , Jiang Yuxin , Xu Zhonghui , Ouyang Yunshu , Li Shengli , Chen Qian , Wu Qingqing , Li Rui , Ru Tong , Cai Ailu , Chen Xinlin , Yang Taizhu , Chen Ping , Xie Hongning , Lu Hong , Dai Qing , Dong Fen , Yang Meng , Yang Xiao , Lu Jia , Tian Jiawei , Sun Kun , Li Hui 
Published: May 2021

Abstract
Background: To develop an ultrasonographic dating formula for predicting gestational age (GA) based on fetal crown–rump length (CRL) in a Chinese population, evaluate its systematic prediction error and compare it with existing formulae.Methods: This was a prospective cross-sectional study of spontaneously conceived singleton pregnancies among women with a regular menstrual cycle in the preceding year. Ultrasound examinations were performed at 11–14 weeks according to the date of the last menstrual cycle. The CRL was measured three times for each fetus, and the mean was used to derive the best-fit fractional polynomial regression model for estimation of GA in relation to CRL. For each fetus, the GA was compared with the GA calculated using six established dating formulae based on CRL measurements. The means of the differences between estimated and menstrual age were calculated for each formula. All the women were followed up routinely until the birth of the fetus. Results: Of the 4710 subjects recruited, the mean and standard deviation values of CRL changed linearly with GA. The corresponding regression equation and its correlation coefficient (R2) was GA = 59.361513 + 0.461425 ´ CRL (R2 = 0.8028). The mean difference between estimated and menstrual age was 0.22 days (95% confidence interval 0.05–0.21), lower than that of the six existing CRL dating formulae.Conclusions: We have derived a CRL-based dating formula suitable for naturally conceived pregnancies for GA between 11+0 and 13+6 weeks. The formula has no systematic prediction error, comparing favorably with the existing published dating formulae.
Effects of polypropylene, polyvinyl chloride, polyethylene terephthalate, polyurethane, high-density polyethylene, and polystyrene microplastic on Nelumbo nucifera (Lotus) in water and sediment
Authors: Esterhuizen Maranda , Kim Youngjun 
Published: May 2021

Abstract
Plastic waste is recognised as hazardous, with the risk increasing as the polymers break down in nature to secondary microplastics or even nanoplastics. The number of studies reporting on the prevalence of microplastic in every perceivable niche and bioavailable to biota is dramatically increasing. Knowledge of the ecotoxicology of microplastic is advancing as well; however, information regarding plants, specifically aquatic macrophytes, is still lacking. The present study aimed to gain more information on the ecotoxicological effects of six different polymer types as 4 mm microplastic on the morphology (germination and growth) and the physiology (catalase and glutathione S-transferase activity) of the rooted aquatic macrophyte, Nelumbo nucifera. The role of sediment was also considered by conducting all exposure both in a sediment-containing and sediment-free exposure system. Polyvinyl chloride and polyurethane exposures caused the highest inhibition of germination and growth compared to the control. However, the presence of sediment significantly decreased the adverse effects. Catalase activity was increased with exposure to polyvinyl chloride, polyurethane, and polystyrene, both in the presence and absence of sediment but more so in the sediment-free system. Glutathione S-transferase activity was significantly increased with exposure to polypropylene, polyvinyl chloride, and polyethylene terephthalate in the sediment-free system and exposure to polyethylene terephthalate and polyurethane in the absence of sediment. There was no clear correlation between the morphological and physiological effects observed. Further studies are required to understand the underlying toxicity mechanism of microplastics.
Hip, Vertebral, and Wrist Fracture Risks and Schizophrenia: A Nationwide Longitudinal Study
Authors: Chu Yu-Wen , Chen Wen-Pin , Yang Albert C. , Tsai Shih-Jen , Hu Li-Yu , Lee Shyh-Chyang , Lee Yao-Tung , Shen Cheng-Che 
Published: May 2021

Abstract
Background: Fractures are a great health issue associated with morbidity, quality of life, life span, and health care expenditure. Fractures are correlated with cardiovascular disease, type 2 diabetes mellitus, cerebrovascular disease, and some psychiatric disorders. However, representative national data are few, and longitudinal cohort studies on the association between schizophrenia and the subsequent fracture risk are scant. We designed a nationwide population-based cohort study to investigate the association of schizophrenia with hip, vertebral, and wrist fractures over a 10-year follow-up. Methods: Data of patients with schizophrenia (International Classification of Diseases, Ninth Revision, Clinical Modification code 295) and matched over January 2000–December 2009) were extracted from Taiwan National Health Insurance Research Database. A Cox proportional-hazards regression model was constructed to calculate hazard ratios (HRs) for fractures between the schizophrenia and control cohorts. Results: Of 2,028 people with schizophrenia (mean age: 36.3 years, 49.4% female), 89 (4.4%) reported newly diagnosed fractures—significantly higher than the proportion in the control population (257, 3.2%; P = 0.007). The incidences of hip (1.2%, P = 0.009) and vertebral (2.6%, P = 0.011) fractures were significantly higher in the schizophrenia cohort than in the control cohort. In Cox regression analysis, hip (adjusted HR: 1.78, 95% confidence interval [CI]: 1.08–2.93) and vertebral (adjusted HR: 1.40, 95% CI: 1.01–1.95) fracture risks were significantly higher in patients with schizophrenia. Furthermore, a sex-based subgroup analysis revealed that the risk of hip fracture remained significantly higher in female patients with schizophrenia (HR: 2.68, 95% CI: 1.32–5.44) than in female controls. On the other hand, there was no significant interaction between effects of sex and schizophrenia on the risk of fractures. Conclusions: Over a 10-year follow-up, hip and vertebral fracture risks were higher in the people with schizophrenia than in the controls. The risk of fractures in patients with schizophrenia does not differ between female and male.
DOA Estimation Based on Sum-Difference Coarray with Virtual Array Interpolation Concept
Authors: Ding Yarong , Ren Shiwei , Wang Weijiang , Xue Chengbo 
Published: May 2021

Abstract
The sum-difference coarray is the union of difference coarray and the sum coarray, which is capable to obtain a higher number of degrees of freedom (DOF) than the difference coarray. However, this method fails to use all information provided by the coprime array because of the existence of holes. In this paper, we introduce the virtual array interpolation into the sum-difference coarray domain. After interpolating the virtual array, we estimate the DOA by reconstructing the covariance matrix to resolve an atomic norm minimization problem in a gridless way. The proposed method is gridless and can effectively utilize the DOF of a larger virtual array. Numerical simulation results verify the effectiveness and the superior performance of the proposed algorithm.