bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF DEGRADATION, BIOCOMPATIBILITY AND CALCIFICATION CHARACTERISTICS OF BIOMATERIALS FOR VASCULAR SURGERY
Authors: Prokudina Ekaterina S. , Antonova Larisa V. , Senokosova Eugenia A. , Krivkina Eugenia O. , Sinitskaya Anna V. , Kolomeets Marina S. , Kochergin Nikita A. 
Published: February 2025

Highlights Silk fibroin is resistant to early degradation, focal calcification, adsorbs albumin, and does not cause pronounced local and systemic inflammation during subcutaneous implantation in rats, which is comparable and even superior in properties to bovine pericardium used in vascular surgery. Aim. To study the hydrolytic degradation of silk fibroin (SF), to evaluate in a comparative aspect the surface adsorption of proteins by matrices from SF and bovine pericardium (BP), calcification of biomaterials, as well as their biocompatibility, the dynamics of biodegradation and systemic inflammation after subcutaneous implantation in rats.Methods. Matrices from SF were made by electrospinning. The BP flap was used as a comparison material. The loss of SF mass and the change in pH of the incubation solution during its hydrolytic degradation in vitro were studied at periods of 1, 3, 6, and 12 months. The surface adsorption of albumin and fibrinogen by matrices was assessed in vitro. Samples of SF and BP were implanted subcutaneously in rats for periods of 7, 14, 30, and 60 days. After explantation of the matrices, a histological examination of the samples was performed and their calcification was assessed. The levels of interleukins 6 and 8, tumor necrosis factor-α, and monocyte chemotactic protein-1 were studied in the blood serum of rats using the enzyme immunoassay method.Results. Hydrolytic degradation of SF in vitro resulted in a 6% loss of the matrix mass and was accompanied by a decrease in the pH of the incubation solution to 6.56. Twice as much albumin and six times as much fibrinogen were adsorbed on the SF surface than on the BP surface. Signs of SF biodegradation and a thin connective tissue capsule around the matrix appeared after 30 days of subcutaneous implantation in rats. No pronounced inflammation or calcification of SF were detected. Subcutaneous implantation of BP was accompanied by the formation of a pronounced connective tissue capsule around the sample after 60 days, fraying, and degradation of the material. Localized foci of calcification were not detected at any time point of subcutaneous implantation. The content of proinflammatory cytokines in the blood serum of rats after subcutaneous implantation of SF and BP decreased by day 60 of the study without statistically significant intergroup differences.Conclusion. Due to its resistance to premature degradation and calcification, increased surface adsorption of albumin, optimal biocompatibility and the absence of pronounced peri-implantation and systemic inflammation, SF is comparable and also has a number of advantages compared to BP used in vascular surgery.
ENDOVASCULAR TRANSCATHETER PULMONARY VALVE REPLACEMENT USING BALLOON-EXPANDABLE DEVICES: A LITERATURE REVIEW
Authors: Pursanov Manolis G. 
Published: February 2025

HighlightsThe development of new valve devices (SAPIEN, Myval) with a large size range has significantly expanded the possibilities of endovascular treatment of pulmonary valve dysfunction. It became possible to treat pulmonary regurgitation in patients with obstructive right ventricular outflow tract and in patients with transannular patch repair of pulmonary trunk and right ventricular outflow tract enlargement. Based on the analysis of literature data, this work examines modern valve design features, indications, methods and techniques of their implantation, as well as clinical results. Abstract The paper analyzes the effectiveness and safety of endovascular transcatheter pulmonary valve replacement using balloon-expandable devices. The authors conducted a review of the literature on this topic, studied the available clinical trial data and case reports, and analyzed the main technical aspects of the replacement procedure. The study results helped to assess the effectiveness of the procedure, indications and complications associated with its use. It can be concluded that endovascular transcatheter pulmonary valve replacement using balloon-expandable devices is a promising alternative treatment method for certain patients with heart defects. However, further research is needed to optimize the technique and improve the results of the procedure.
THE ROLE OF THE LEFT ATRIAL APPENDAGE IN THE PATHOGENESIS OF ATRIAL FIBRILLATION, THE EFFECTIVENESS OF ABLATION AND THE DEVELOPMENT OF THROMBOEMBOLIC COMPLICATIONS
Authors: Filippenko Alexey G. , Beloborodov Vladimir V. , Elesin Dmitry A. , Stenin Ilya G. , Shirokova Natalia V. , Baranova Vera V. , Shabanov Vitaly V. 
Published: February 2025

HighlightsLeft atrial appendage resection is a safe and effective method of excluding the appendage from the systemic circulation, it reduces the number of cerebral ischemic events and increases the effectiveness of atrial fibrillation treatment. AbstractAccording to a number of studies, left atrial appendage can be the source of atrial fibrillation. Moreover, in atrial tachyarrhythmias, the appendage is the main source of thrombosis that causes cerebral ischemic events. In an attempt to solve these two issues, specialists developed various devices to exclude the left atrial appendage from the systemic circulation and attempted to ablate the arrhythmogenic area. The aim of this review is to analyze current literature data on the abovementioned issues and our own experience of left atrial appendage resection during thoracoscopic pulmonary vein ablation in patients with persistent atrial fibrillation.
SPEECH AS MAIN COGNITIVE FUNCTION IN CHILDREN WITH CONGENITAL HEART DEFECT: STUDYING THE FORMATION OF THE GRAMMATICAL STRUCTURE
Authors: Rumyantseva Alexandra A. , Kameneva Veronika A. , Potapova Natalia V. 
Published: February 2025

HighlightsThis review presents the latest available literature data on cognitive and speech characteristics of children with congenital heart defects (CHD), and describes the findings regarding the formation of the grammatical structure of speech in adolescent children with congenital heart defects. Aim. To assess the development of the grammatical structure of speech in adolescents undergoing surgery for congenital heart defects.Methods. The prospective study of the formation of grammatical structure of speech included 37 adolescent children in the early postoperative period after radical surgical treatment of septal heart defects at the Research Institute for Complex Issues of Cardiovascular Diseases.Results. The grammatical structure of speech in adolescents aged 13–16 years with septal congenital heart disease after surgical intervention is not sufficiently formed, the greatest difficulties are associated with changing the form of words. The lowest average score was obtained when performing the task of selecting the appropriate preposition in a sentence (average score – 6.70) and when verifying errors in sentences (average score – 4.97). The highest success rate occurred in the tasks consisting of repeating read sentences and completing unfinished sentences (average scores 10.7 and 13.10, respectively).Conclusion. For adolescents after surgical correction of CHD to be able to freely chose profession and properly socialize, it is necessary to take into account postoperative results with an assessment of clinical and hemodynamic characteristics, and the quality of life, including neurocognitive status.
IMPROVING PRIMARY HEALTH CARE FOR THE COAL INDUSTRY WORKERS (USING THE EXAMPLE OF THE KEMEROVO REGION – KUZBASS)
Authors: Bazdyrev Evgeny D. , Strokolskaya Irina L. , Chasovskikh Elena V. , Zhilyaeva Tatiana P. , Makarov Sergey A. , Tsygankova Daria P. , Agienko Alena S. , Tsenter Iosif M. , Heraskov Vitaliy Yu. , Artamonova Galina V. 
Published: February 2025

HighlightsThe article presents proposals for improving primary health care for the coal industry workers by creating specialist outpatient clinics, integrating medical organizations at all levels, and incorporating an interdepartmental approach for various ministries and departments to preserve the health of the able-bodied population. Aim. To develop a promising model for organizing health services for coal industry employees in the Kuzbass (using the Kemerovo region – Kuzbass data).Methods. The object of the study is the organization of primary health care (PHC) for coal industry employees. The subject of the study are the coal industry employees. The analytical method and content analysis of domestic and foreign literature and regulatory documents regarding the organization of primary health care for employees (federal laws of the Russian Federation, regulatory documents of the Ministry of Healthcare, Ministry of Labor and Social Protection of the Russian Federation and Kemerovo region-Kuzbass) were used in this review.Results. The new model of the organization of PHC for coal industry employees has three levels of interdepartmental interaction. The first level involves new specialized outpatient clinics for the working population that should be created within territorial polyclinics as the main link in the provision of primary health care with the support from enterprises and the occupational pathology service providers of the region. The second level involves the identification of cardiovascular risk factors, diagnosis of cardiovascular diseases, and developing personal preventive measures for patients. The third level of the model is managerial, it aims to develop preventive programs to negate occupational-related adverse factors and implement them at personal, workplace and interdepartmental levels.Conclusion. The interdepartmental approach involving all participants of the process will be able to achieve the target parameters by improving the PHC model for the working population. The developed model will shorten the wait times, simplify document management, ensuring continuity, monitoring of cardiovascular risk factors, outpatient management of patients with premorbid disorders, and interdepartmental responsibility for outcomes.
THE EFFECTIVENESS OF COGNITIVE TRAINING WITH THE USE OF A COMBINATION OF SIMPLE VISION-MOTOR AND A SET OF ARITHMETIC AND VERBAL TASKS IN EARLY PREVENTION IN PATIENTS AFTER CORONARY ARTERY BYPASS SURGERY
Authors: Trubnikova Olga A. , Tarasova Irina V. , Syrova Irina D. , Temnikova Tatiana B. , Sosnina Anastasia S. , Kupriyanova Darya S. , Barbarash Olga L. 
Published: February 2025

HighlightsThe effectiveness of cognitive rehabilitation in reducing the incidence of early postoperative cognitive dysfunction in patients who have undergone coronary artery bypass grafting has been demonstrated for the first time by optimizing neurodynamics and memory parameters. AbstractAim. To study the effectiveness of cognitive training (CT) using a combination of simple visual-motor reactions with a set of arithmetic and verbal tasks to reduce the frequency of early postoperative cognitive dysfunction (POCD) in patients who underwent coronary artery bypass grafting (CABG), and to evaluate the dynamics of the neurovascular unit markers (NVU).Methods. The prospective randomized study included 81 patients: group with CT (n = 43) and the comparison group without CT (n = 38). All patients underwent general clinical, laboratory and instrumental examinations as well as extended neuropsychological examination and determination of concentrations in the plasma of peripheral blood of NVU markers.Results. Patients who underwent CT with a combination of vision-motor task and cognitive components in the early post-operative period of CABG showed better psychomotor and executive functions (faster reaction time, a smaller number of errors and missed signals), as well as attention (more processed symbols in the 4th minute of Burdon’s test) compared to patients without training. The patients with CT also had a decrease in the concentration of S100β protein in peripheral blood at 11–12 days after CABG and a tendency towards higher the concentration of BDNF. The comparison group had an increase in the concentration of S100β protein at 1st day after surgery and maintained an elevated level until 11–12 days after CABG.Conclusion. Thus, the cognitive rehabilitation as the combinations of simple visual-motor reactions with a set of arithmetic and verbal tasks in the early postoperative period of CABG contributed to a decrease in the incidence of early POCD and the maintenance of the cognitive status of patients to a greater extent due to the optimization of the activity of the neurodynamic and short-term memory domains. The decrease in the concentration of S100β protein in the peripheral blood at 11–12 days after CABG and the tendency towards higher concentration of BDNF, observed in patients with CT in comparison to patients without CT, may indicate NVU reorganization.
THE CHANGES IN NEUROPHYSIOLOGICAL PARAMETERS AND NEUROVASCULAR UNIT MARKERS IN CARDIAC SURGERY PATIENTS UNDER THE INFLUENCE OF MULTITASK TRAINING IN A THREE-DIMENSIONAL ENVIRONMENT
Authors: Trubnikova Olga A. , Tarasova Irina V. , Kukhareva Irina N. , Kupriyanova Darya S. , Gorbatovskaya Evgeniya E. , Sosnina Anastasia S. , Temnikova Tatiana B. , Lyapina Irina N. 
Published: February 2025

HighlightsFor the first time it was demonstrated that changes in the neurophysiological parameters and markers of the neurovascular unit in cardiac surgery patients under the influence of multitask training in a three-dimensional environment result in optimization of the attention and short-term memory domains, the absence of significant dynamics of low-frequency theta activity and a pronounced activation of BDNF synthesis in contrast to patients without training. AbstractAim. To study the changes in a complex index of cognitive status in the neurodynamic, attention and short-term memory domains, electroencephalogram (EEG) indices and neurovascular unit (NVU) markers in cardiac surgery patients under the influence of multitask training in a three-dimensional environment.Methods. The prospective randomized study included 100 patients who were divided into two groups using the envelope method: 47 patients underwent a course of multitask training in a three-dimensional environment and 53 patients received no training. In addition to a standard clinical examination, all patients underwent an extended study of cognitive status, EEG parameters, and NVU markers in peripheral blood.Results. The complex indicators of attention and short-term memory improved at 11–12 days after CABG compared to preoperative values, but only in patients who underwent training. There were no significant changes in complex indicators of cognitive domains in patients without training. Analysis of the EEG total power revealed that theta 1 rhythm indicators did not statistically differ from preoperative values in patients who underwent training. In the group without training, the increase in theta activity (theta1 and theta2) was significant, as was beta 1–2 activity. The dynamics of changes in the BDNF indicator demonstrated that in patients with training, who had an increase in BDNF concentrations in the peripheral blood on the 1st day after CABG, there was no development of early POCD at 11–12 days after cardiac surgery.Conclusion. The multitask trainings in a three-dimensional environment contributed to a decrease in the incidence of POCD at the end of the in-hospital stage of CABG due to optimization of the activity of the attention and short-term memory domains. The positive effect of the training was the absence of significant dynamics of low-frequency theta activity and a more pronounced activation of BDNF compared to patients without training, which may indicate a reorganization of brain activity and NVU, but this effect requires confirmation in further studies.
IN-HOSPITAL OUTCOMES OF ALCOHOL SEPTAL ABLATION IN THE TREATMENT OF PATIENTS WITH HYPERTROPHIC SUBAORTIC STENOSIS: RESULTS OF A SINGLE CENTER STUDY
Authors: Ganyukov Vladimir I. , Danilovich Arina I. , Evtushenko Alexey V. , Tarasov Roman S. 
Published: February 2025

HighlightsThe review is devoted to the analysis of baseline and in-hospital outcomes of patients with hypertrophic cardiomyopathy after alcohol septal ablation.The results showed that efficacy and safety of alcohol septal ablation in the treatment of patients with hypertrophic cardiomyopathy is comparable to surgical myectomy of the left ventricular outflow tract. Aim. To analyze cases of patients undergoing alcohol septal ablation (ASA) at the Research Institute, assessing patients' baseline status, perioperative data and in-hospital outcomes, and to prove that efficacy and safety of ASA in the treatment of patients with hypertrophic cardiomyopathy (HCM) is comparable to surgical myectomy of the left ventricular outflow tract (LVOT) taking into account the available literature data.Materials and Methods. The study included 25 patients with HCM and LVOT obstruction who underwent ASA at the Research Institute for Complex Issues of Cardiovascular Diseases between 2018 and September 2022. The feasibility of the procedure was based on echocardiographic (LVOT obstruction with peak gradient ≥ 50 mm Hg) and angiographic data (absence of coronary bed lesions, and presence of septal branches with diameter of at least 2 mm). The intervention was performed only in case of a “positive” balloon test, i.e. peak gradient decrease by 30% or more compared to baseline during balloon inflation in the target septal branch.Results. We considered the decrease of LVOT peak gradient by more than 50% compared to baseline to be a success criterion of the procedure. In in-hospital setting there were no endpoints (death, stroke, blockage of left anterior descending artery, permanent pacemaker implantation), and temporary cardiac pacing was required only in 2 cases (8%) due to transient AV blockade. The echocardiography showed that the peak LVOT pressure gradient was 35 [10; 87] mmHg on the 1st day, and 20 [8; 75] mmHg on the 5th day. Conclusion. The findings and the experience of other clinics proved that ASA can be used in the treatment of patients with HCM and is comparable to surgical myectomy in terms of efficacy. However, patient selection for ASA should be thorough and include clinical and demographic indicators, and echocardiography and angiography data.
INFARCT-REDUCING EFFECT OF DELTORPHIN II IN REPERFUSION OF THE HEART. THE ROLE OF NO-SYNTHASE, GUANYLYLCYCLASE, cGMP, MPT PORE
Authors: Popov Sergey V. , Mukhomedzyanov Alexandr V. , Kurbatov Boris K. , Azev Viacheslav N. , Sufianova Galina Z. , Khlestkina Maria S. , Sarybaev Akpay Sh. , Maslov Leonid N. 
Published: February 2025

HighlightsThe selective δ2-opioid receptor agonist deltorphin II increases cardiac tolerance to reperfusion by activating guanylyl cyclase, stimulating cGMP synthesis, activating sarcKATP channel, and blocking MPT pore. Aim. To evaluate the role of NO-synthase, guanylyl cyclase, cGMP, MPT pore in the infarct-limiting effect of deltorphin II in the model of ischemia and reperfusion of the rat heart.Methods. Coronary artery occlusion (45 min) and reperfusion (2 h) were performed in rats anesthetized with chloralose. The selective δ2-opioid receptor agonist deltorphin II was administered intravenously at a dose of 120 µg/kg 5 min before reperfusion. The NO synthase inhibitor L-NAME, the guanylyl cyclase inhibitor ODQ, and the MPT pore blocker atractyloside were administered intravenously 10 min before reperfusion. The cAMP and cGMP levels were measured in myocardial tissue.Results. Deltorphin II causes a decrease in infarct size by about 50%. L-NAME did not affect the cardioprotective effect of deltorphin. Atractyloside and ODQ completely abolished the infarct-reducing effect of deltorphin. Deltorphin II caused an increase in the cGMP level in the myocardium, but did not affect the cAMP level.Conclusion. Analysis and generalization of obtained data and the results of previous studies indicate that the infarct-limiting effect of deltorphin II is associated with activation of δ2-opioid receptors located in cardiomyocytes, followed by activation of heme oxygenase-1, an increase in CO production, stimulation of guanylyl cyclase, and activation of protein kinase G. The putative end-effectors are MPT pore and sarcKATP channel. In turn, NO synthase is not involved in signal transduction from δ2-OR to the MPT pore and sarcKATP channel.
Counterstereotypical Materials as a Method of Reducing Prejudice Toward Childfree People
Authors: Ciesielski Paweł 
Published: February 2025

Childfree people face prejudice, discrimination, and misunderstanding. This study explores three methods of reducing such prejudice based on video materials: counterstereotypicality (CS), exposition (EXPO), and counterstereotypical exposition (CS-EXPO). Prejudice was measured twice: first, in a pretest, and then in a posttest that followed the video material, two weeks afterwards. The study covered 192 participants (Mage = 30.18), with 46 to 50 participants in each condition (three experimental + one control). In all of the experimental conditions (but not in the control condition), the prejudice was lower in the Posttest, compared to the Pretest. Of the three conditions, the CS and CS-EXPO conditions had the largest effect. However, the results indicated no significant differences between the conditions. Practical implications for prejudice reduction campaigns are discussed.
The Role of Social Isolation in Shaping Hyperfocus in Adults with ADHD and/or ASD: A Cross-Sectional Study
Authors: Folly Julia Carvalho , Reis Lara Emanuelle Silva , Roman-Ramos Henrique 
Published: February 2025

Abstract

Objective: Hyperfocus (HF) is frequently observed in individuals with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). While HF can enhance cognitive performance, it often disrupts daily functioning. This study assessed how pandemic-induced social isolation influenced HF intensity and frequency in adults with ASD, ADHD, or both conditions (ADHD&ASD), focusing on disparities in diagnostic and therapeutic access.
Methods: A cross-sectional study was conducted using an adapted Adult Hyperfocus Questionnaire to collect HF scores from 342 adults with ASD, ADHD, or ADHD&ASD. Participants included those with formal diagnoses and self-reported neurodivergence, reflecting barriers to equitable diagnostic access. HF scores were compared between pre-isolation and during-isolation periods. Statistical analysis examined variations by neurodivergent condition, diagnostic status, and therapy participation. Sentiment analysis evaluated emotional responses to HF episodes.
Results: Social isolation significantly increased HF across all groups (p < 0.001). Median HF scores rose from 68 to 72 (ADHD), 67 to 71 (ASD), and 68 to 70 (ADHD&ASD). No significant differences were observed between formally diagnosed and self-reported individuals or those in therapy, highlighting disparities in access to support. Sentiment analysis revealed predominantly positive emotions during HF but identified challenges like neglect of basic needs and systemic inequities.
Conclusion: Social isolation amplified HF behaviours in neurodivergent adults. Disparities in diagnostic and therapeutic access emphasise the need for equity-focused interventions. Tailored strategies addressing environmental stressors and systemic barriers are crucial to supporting underserved neurodivergent populations, particularly during crises.