bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Konseling Menyusui Dalam Rangka Pencegahan Stunting Melalui Pemberian Air Susu Ibu Dengan Dinas Kesehatan Kabupaten Jombang Di Kabupaten Jombang
Authors: Probowati Ririn , Sawitri Prihatini Monika , Ratnawati Mamik 
Published: April 2021

Counseling is a series of contacts or direct relationships with individuals whose purpose is to provide assistance in changing their attitudes and behavior (Taufik, 2010). In order for mothers to maintain exclusive breastfeeding for 6 months, WHO recommends initiating breastfeeding within the first hour of life, babies only receive breast milk without additional food or drink, including water, breastfeed as requested or as often as the baby wants, and do not use bottles or pacifiers. (WHO, 2018). Based on data from the Ministry of Health, there is an increase in the provision of breastfeeding (breast milk) during a pandemic COVID-19 by 52 percent. This figure has increased significantly compared to last year. "Compared to the 2019 period, there is an increase in breastfeeding in 2020. It increases from 20 percent to 52 percent in the first trimestes of 2020. East Java is currently not far from the national figure, reaching 26.91 percent with the highest risk of stunting in the districts of Probolinggo, Trenggalek, Jember, Bondowoso and Pacitan . The stunting rate in Jombang Regency has decreased by 1 percent compared to 2019. Namely from 18 percent to 17 percent in 2020. According to her, the highest stunting cases in Jombang are in five areas, namely Plabuhan, Plandaan, Mayangan and Distance Kulon districts, Jogoroto, Kabuh, districts. and Blimbing Kesamben District. The purpose of this activity is to provide guidelines for members of the counselor group at PONED puskesmas in the Jombang district health office . The results of this activity , terbetuknya breastfeeding counselor groups in each puskesmas PONED in Jombang district, a group of counselors will provide assistance to the motivator and mother - pregnant women and nursing mothers in order to give exclusive breastfeeding are one factor un tuk prevent stunting in bali ta . In this activity the number of participants who took part in the Breastfeeding Counseling Training in the Context of Stunting Prevention through Breastfeeding in Jombang district was 19 participants during the pandemic period . .

Keywords : Breastfeeding Counseling , Stunting , Breastfeeding
Pengaruh Terapi Konseling Realitas dalam Mengurangi Stigma Diri pada Penderita TB
Authors: Sari Nur Maya , Amirus Khoidar , Febriani Christin Angelina 
Published: April 2021

Bandar Lampung menempati urutan kedua tertinggi penemuan kasus TB. Promosi kesehatan berbentuk konseling realitas memiliki pengaruh dalam mengurangi stigma diri pada pasien TB untuk peningkatan kesehatan. Tujuan dari penelitian ini diketahui Pengaruh Terapi Konseling Realitas Dalam Mengurangi Stigma Diri pada Penderita TB di Wilayah Kerja Puskesmas Satelit Bandar Lampung. Penelitian kuantitatif dengan pendekatan quasy experiment dengan two group pretest-posttest design. Sampel penelitian ini adalah Pasien TB di Wilayah Kerja Puskesmas Satelit Bandar lampung sebesar 26 orang. Teknik pengambilan sample menggunakan purposive sampling. Sample dibagi menjadi dua kelompok yaitu kelompok yang diberikan konseling realitas dan kelompok kontrol. Analisis yang digunakan yaitu analisis univariat dan bivariat dengan uji T-Dependen (Paired-Samples T-Test dan uji T-Independen (Samples T-Test). Ada perbedaan stigma pada kelompok kontrol dan eksperimen sebelum dan sesudah diberikan konseling realitas dengan nilai p-value <0.001. Konseling realitas memiliki pengaruh dalam mengurangi stigma pada pasien TB. Saran untuk penelitian selanjutnya agar membandingkan dengan metode terapi konseling kognitif dan aktifitas kelompok.
Hubungan Pekerjaan dengan Perilaku Merokok di Wilayah Kerja Puskesmas Bumi Emas Lampung Timur
Authors: Yanti Dhiny Easter , Aprilia Aprilia , Jaya Arnan , Pratama Randy Yusuf , Candesa Natasya Beggy 
Published: April 2021

Sejak 2013 prevalensi merokok pada penduduk Indonesia terus meningkat. Hal ini dapat merugikan kesehatan perokok sendiri, kesehatan lingkungan sekitarnya (sebagai merokok pasif), dan merugikan negara (meningkatnya biaya kesehatan). Tujuan penelitian diketahuinya hubungan pekerjaan dengan prilaku merokok pada masyarakat di wilayah kerja puskesmas Bumi Emas, Lampung Timur 2020. Jenis penelitian kuantitatif, dengan rancangan cross sectional. Sampel 288 responden (data mawas diri Puskesmas Bumi Emas, Lampung Timur 2020). Analisis data secara univariat dan bivariat dengan uji Somers’D. Penelitian menujukkan perokok aktif lebih banyak (70,8%) dibandingkan dengan tidak merokok (29,2%). Jenis pekerjaan responden pada umumnya petani dan buruh (72,2%), paling sedikit jenis pekerjaan pensiunan. Hasil uji Somers’D diperoleh nilai = 0,071 artinya terdapat hubungan lemah antara pekerjaan dengan perilaku merokok, berpola positif. Disimpulkan pekerjaan berpengaruh terhadap perilaku merokok namum pengaruhnya lemah. Disarankan puskesmas dapat berkerjasama dengan lintas sektoral untuk meningkatkan penerapan kawasan tanpa rokok (KTR) di wilayah kerja Puskesmas Bumi Emas Lampung Timur.
Kentsel Mültecilerin Kente Uyum Süreçlerinde Konuta Erişimleri: Hatay Örneği
Authors: Güngördü Zehra , Özbakır Buket Ayşegül 
Published: April 2021

İçinde bulunduğumuz çağ kitlesel göç hareketlerinin pek çok farklı gerekçeyle ve dinamiklerle gerçekleştiği süreçleri barındırmaktadır. Kitlesel göçün, kentler ve kentsel politikalar üzerinde pek çok etkisi olduğu birçok araştırmada tespit edilmiştir. Türkiye 2011 yılından beri, Suriye’den gelen zorunlu kitlesel göç hareketinin sosyal, ekonomik, kültürel ve mekânsal etkilerini deneyimlemektedir. Dört milyona yakın Suriyeli mültecinin konuta erişiminin nasıl gerçekleştiği, barınma sorununun nasıl çözüldüğü ve bunların Suriyeli mültecilerin kente uyum süreçlerine nasıl yansıdığı araştırılması gereken ve önemli boyutları olan konulardır. Bu çalışma, Hatay’da yaşayan Suriyeli mültecilerin kente uyum süreçlerinde önemli bir faktör olan, konut deneyimlerini; yerleştikleri mahalleyle ve kentle kurdukları ilişki üzerinden incelemeyi hedeflemektedir. Bu araştırmadan elde edilen en önemli sonuç, konuta erişim faktörünün, Suriyeli mültecilerin kentsel uyum süreçlerinde, önemli bir politika başlığı olarak geliştirilmesi gereken bir husus olduğudur. Bu çalışmanın bulguları “Kentsel Mültecilerin Adaptasyon ve Uyum Süreçlerine Yeni Bir Bakış Açısı: Kapsayıcı Kent İnşası Amaçlı Sosyal İnovasyon Deneyi” başlıklı, 117K826 Kodlu ve TÜBİTAK 1003- Öncelikli Alanlar AR-GE Projeleri Destekleme Programı kapsamındaki araştırma projesinden elde edilmiştir.
Duration of Parathyroid Function Recovery in Patients With Protracted Hypoparathyroidism After Total Thyroidectomy for Papillary Thyroid Carcinoma
Authors: Qiu Yuxuan , Xing Zhichao , Xiang Qiao , Yang Qianru , Su Anping , Luo Yan 
Published: April 2021

PurposeThe aim of the present study is to investigate the time to recovery of parathyroid function in patients with protracted hypoparathyroidism at 1 month after total thyroidectomy of papillary thyroid carcinoma.Materials and MethodsAdult patients who underwent total thyroidectomy for papillary thyroid cancer were included. Cases of long-term hypoparathyroidism were studied for recovery of parathyroid function during the follow-up. The duration of recovery and associated variables were recorded.ResultsOut of the 964 patients, 128 (13.28%) developed protracted hypoparathyroidism and of these, 23 (2.39%) developed permanent hypoparathyroidism and 105 (10.89%) recovered: 86 (8.92%) before 6 months, 11 (1.14%) within 6 and 12 months and 8 (0.83%) after 1 year follow-up. Variables significantly associated with the time to parathyroid function recovery were number of autotransplanted parathyroid glands (HR, 1.399; 95% CI, 1.060 – 1.846; P = 0.018), serum calcium concentration &gt;2.07 mmol/L (Hazard ratio [HR], 1.628; 95% confidence interval [CI], 1.009 – 2.628; P = 0.046) and PTH level &gt; 1.2 pmol/L (HR, 1.702; 95% CI, 1.083 – 2.628; P = 0.021) at 1 month postoperatively.ConclusionPermanent hypoparathyroidism should not be diagnosed easily by time, since up to one-fifth of the patients will experience recovery after a period of 6 months and a few patients even beyond one year. The number of autotransplanted parathyroid glands is positively associated with the time to parathyroid function recovery.
Diabetes and Bone Involvement in Primary Hyperparathyroidism: Literature Review and Our Personal Experience
Authors: Castellano Elena , Attanasio Roberto , Boriano Alberto , Borretta Valentina , Tassone Francesco , Borretta Giorgio 
Published: April 2021

BackgroundPrimary hyperparathyroidism (PHPT) and type 2 diabetes mellitus (T2DM) are common endocrine disorders impacting on skeletal health, whose concomitant occurrence is becoming more frequent.Patients and MethodsWe searched the PubMed database from the National Library of Medicine about the relationship between T2DM and its treatment and bone manifestations of PHPT. Thereafter, we retrospectively evaluated a consecutive series of 472 PHPT patients. Among them 55 were also affected by T2DM. At the diagnosis of PHPT we compared bone turnover markers and bone densitometry between 55 patients with and 417 without T2DM and in the former group according to antidiabetic treatment.ResultsFew data are available about T2DM and PHPT bone involvement, studies about T2DM treatments and PHPT bone manifestations are lacking. Among patients with PHPT of our series, those with T2DM were older, had a lower prevalence of osteitis fibrosa cystica, higher lumbar and femoral T-scores than the remaining patients. No difference was disclosed among the diabetic patients according to ongoing antidiabetic treatment, even though modern treatments were under-represented.ConclusionsNo clinical study specifically evaluated the impact of T2DM on bone involvement in PHPT. In our experience, diabetic patients resulted more frequently “mild asymptomatic” than non-diabetic patients and showed a lower prevalence of radiological PHPT bone manifestations. The treatment of T2DM does not seem to affect the biochemical or clinical features of PHPT in our series. Further studies are needed to fully disclose the influence of T2DM and antidiabetic treatment on bone health in patients with PHPT.
Case Report: An Atypical Form of Familial Partial Lipodystrophy Type 2 Due to Mutation in the Rod Domain of Lamin A/C
Authors: Cecchetti Carolina , D’Apice M. Rosaria , Morini Elena , Novelli Giuseppe , Pizzi Carmine , Pagotto Uberto , Gambineri Alessandra 
Published: April 2021

PurposeFamilial partial lipodystrophy type 2 (FPLD2) patients generally develop a wide variety of severe metabolic complications. However, they are not usually affected by primary cardiomyopathy and conduction system disturbances, although a few cases of FPLD2 and cardiomyopathy have been reported in the literature. These were all due to amino-terminal heterozygous lamin A/C mutations, which are considered as new forms of overlapping syndromes.Methods and ResultsHere we report the identification of a female patient with FPLD2 due to a heterozygous missense variant c.604G&gt;A in the exon 3 of the LMNA gene, leading to amino acid substitution (p.Glu202Lys) in the central alpha-helical rod domain of lamin A/C with a high propensity to form coiled-coil dimers. The patient’s cardiac evaluations that followed the genetic diagnosis revealed cardiac rhythm disturbances which were promptly treated pharmacologically.ConclusionsThis report supports the idea that there are “atypical forms” of FPLD2 with cardiomyopathy, especially when a pathogenic variant affects the lamin A/C head or alpha-helical rod domain. It also highlights how increased understanding of the genotype-phenotype correlation could help clinicians to schedule personalized monitoring of the lipodystrophic patient, in order to prevent uncommon but possible devastating manifestations, including arrhythmias and sudden death.
Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs
Authors: Dembele Marieme , Tao Shao , Massoud Amir H. , Miah S. M. Shahjahan , Lelias Sandra , De Groot Anne S. , Mazer Bruce D. 
Published: April 2021

Tregitopes (T regulatory epitopes) are IgG-derived peptides with high affinity to major histocompatibility complex class II (MHCII), that are known to promote tolerance by activating T regulatory cell (Treg) activity. Here we characterized the effect of IgG Tregitopes in a well-established murine model of allergic asthma, demonstrating in vivo antigen-specific tolerance via adoptive transfer of Tregitope-and-allergen-activated Tregs. Asthma is a heterogeneous chronic inflammatory condition affecting the airways and impacting over 300 million individuals worldwide. Treatment is suppressive, and no current therapy addresses immune regulation in severely affected asthmatics. Although high dose intra-venous immunoglobulin (IVIg) is not commonly used in the asthma clinic setting, it has been shown to improve severe asthma in children and in adults. In our laboratory, we previously demonstrated that IVIg abrogates airway hyperresponsiveness (AHR) in a murine model of asthma and induces suppressive antigen-specific T-regulatory cells. We hypothesized that IgG-derived Tregitopes would modulate allergic airway disease by inducing highly suppressive antigen-specific Tregs capable of diminishing T effector cell responses and establishing antigen-specific tolerance. Using ovalbumin (OVA-) and ragweed-driven murine models of allergic airway disease, we characterized the immunoregulatory properties of Tregitopes and performed Treg adoptive transfer to OVA- and ragweed-allergic mice to test for allergen specificity. Treatment with Tregitopes attenuated allergen-induced airway hyperresponsiveness and lung inflammation. We demonstrated that Tregitopes induce highly suppressive allergen-specific Tregs. The tolerogenic action of IgG Tregitopes in our model is very similar to that of IVIg, so we foresee that IgG Tregitopes could potentially replace steroid-based treatment and can offer a synthetic alternative to IVIg in a range of inflammatory and allergic conditions.
Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma
Authors: Fu Fangqiu , Wen Zhexu , Gao Zhendong , Zhao Yue , Li Yuan , Zhang Yang , Chen Haiquan 
Published: April 2021

BackgroundThe role of primary tumor resection in occult M1a lung adenocarcinoma remains unclear, especially for patients receiving targeted therapy. The purpose of this study is to assess the effect of primary tumor resection on overall survival (OS) in lung adenocarcinoma patients with occult pleural disseminations receiving targeted therapy.MethodsLung adenocarcinoma patients with intraoperatively-confirmed occult pleural dissemination (M1a), who hospitalized in the Department of Thoracic Surgery in Fudan Shanghai Cancer Center from May 2008 to December 2017 and received EGFR-TKIs therapy, were enrolled. Log-rank tests were used to compare the survival differences between groups.Results34 patients receiving EGFR-TKIs were enrolled. The majority of them were never smokers (29/34, 85.3%). Among the enrolled patients, 20 (58.8%) patients underwent primary tumor resection, while 14 (41.2%) patients not. There was no distributional difference of baselines between patients undergoing and not undergoing primary tumor resection. Further analyses demonstrated that the patients undergoing primary tumor resection had a prolonged OS compared with those not (log-rank P= 0.042). The 2-year and 5-year OS for patients receiving primary tumor resection and EGFR-TKIs was 90.0% and 60.1%.ConclusionsPrimary tumor resection was associated with improved survival in patients with occult intraoperatively-confirmed M1a adenocarcinoma receiving EGFR-TKIs.
Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain
Authors: Xu Hang , Zhang Xiang Yang , Wang Wei Wen , Wang Jiesi 
Published: April 2021

Hydroxychloroquine (HCQ), which has been proposed as a therapeutic or prophylactic drug for COVID-19, has been administered to thousands of individuals with varying efficacy; however, our understanding of its adverse effects is insufficient. It was reported that HCQ induced psychiatric symptoms in a few patients with autoimmune diseases, but it is still uncertain whether HCQ poses a risk to mental health. Therefore, in this study, we treated healthy mice with two different doses of HCQ that are comparable to clinically administered doses for 7 days. Psychiatric-like behaviors and the expression of related molecules in the brain were evaluated at two time points, i.e., 24 h and 10 days after drug administration. We found that HCQ increased anxiety behavior at both 24 h and 10 days. Furthermore, HCQ decreased the mRNA expression of interleukin-1beta, corticotropin-releasing hormone (Crh), a serotonin transporter (Slc6a4), and a microglia maker (Aif1) in the hippocampus and decreased the mRNA expression of brain-derived neurotrophic factor (Bdnf) in both the hippocampus and amygdala. Lots of these behavioral and molecular changes were sustained beyond 10 days after drug administration, and some of them were dose-dependent. Although this animal study does not prove that HCQ has a similar effect in humans, it indicates that HCQ poses a significant risk to mental health and suggests that further clinical investigation is essential. According to our data, we recommend that HCQ be carefully used as a prophylactic drug in people who are susceptible to mental disorders.
Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients
Authors: Wang Huanhuan , Hu Xiaoyun , Wang Teng , Cui Cheng , Jiang Ji , Dong Kai , Chen Shuai , Jin Chunyan , Zhao Qian , Du Bin , Hu Pei 
Published: April 2021

Aim: Kukoamine B, a small molecule compound, is being developed for the treatment of sepsis in a Phase II clinical trial. The objective of this study was to optimize dosing selection for a Phase IIb clinical trial using an exposure-response model.Methods: Data of 34 sepsis patients from a Phase IIa clinical trial were used in the model: 10 sepsis patients from the placebo group and a total of 24 sepsis patients from the 0.06 mg/kg, 0.12 mg/kg, and 0.24 mg/kg drug groups. Exposure-response relationship was constructed to model the impact of the standard care therapy and area under curve (AUC) of kukoamine B to the disease biomarker (SOFA score). The model was evaluated by goodness of fit and visual predictive check. The simulation was performed 1,000 times based on the built model.Results: The data of the placebo and the drug groups were pooled and modeled by a nonlinear mixed-effect modeling approach in sepsis. A latent-variable approach in conjunction with an inhibitory indirect response model was used to link the standard care therapy effect and drug exposure to SOFA score. The maximum fraction of the standard care therapy was estimated to 0.792. The eliminate rate constant of the SOFA score was 0.263/day for the standard care therapy. The production rate of SOFA score (Kin) was estimated at 0.0569/day and the AUC at half the maximal drug effect (EAUC50) was estimated at 1,320 h*ng/mL. Model evaluation showed that the built model could well describe the observed SOFA score. Model-based simulations showed that the SOFA score on day 7 decreased to a plateau when AUC increased to 1,500 h*ng/mL.Conclusion: We built an exposure-response model characterizing the pharmacological effect of kukoamine B from the standard care therapy in sepsis patients. A dose regimen of 0.24 mg/kg was finally recommended for the Phase IIb clinical trial of kukoamine B based on modeling and simulation results.
Solar Radiation on a Parabolic Concave Surface
Authors: Aronescu Avi , Appelbaum Joseph 
Published: April 2021

Curved structures are used in buildings and may be integrated with photovoltaic modules. Self-shading occurs on non-flat (curved) surface collectors resulting in a non-uniform distribution of the direct beam and the diffuse incident solar radiation along the curvature the surface. The present study uses analytical expressions for calculating and analyzing the incident solar radiation on a general parabolic concave surface. Concave surfaces facing north, south and east/west are considered, and numerical values for the annual incident irradiations (in kWh) are demonstrated for two locations: 32° N (Tel Aviv, Israel) and 52.2° N (Lindenberg, Germany). The numerical results show that the difference in the incident global irradiation for the different surface orientations is not very wide. At 32° N, the irradiation difference between the south and north-oriented surface is about 15 percent, and between the south and east surface orientation it is about 9.6 percent. For latitude 52.2° N, the global irradiation difference between the south and north-oriented surface is about 16 percent, and between the south and east orientation it is about 3 percent.
Hubungan Disiplin dan Kreatifitas Guru dengan Produktifitas Kerja Guru
Authors: Rahmat Hidayat Agus 
Published: April 2021

Untuk menjamin tercapainya produktifitas guru , maka diperlukan sikap disiplin dan kreatifitas guru dalam upaya menningkatkan kecerdasan peserta didik Guru dituntut untuk meningkatkan disiplin yang dapat memberikan potensi demi kelancaran tugasnya. Usaha untuk meningkatkan kreatifitas dan disiplin guru, sorang Guru pada akhirnaya akan menemukan prodiktifitas kerja secara efektif, efisien dan terjadual. di MTsN Bantarkawung Kab. Brebes. Penelitian ini merupakan penelitian kuantitatif dengan metode penelitian yang digunakan adalah metode survey. Penelitian survey biasa digunakan untuk menerangkan suatu fenomena sosial atau suatu peristiwa sosial. Pada umumnya survey dibatasi pada penelitian yang datanya dikumpulkan dari sampel atas populasi untuk mewakili seluruh populasi dan sebagai alat pengumpul data yang pokok adalah kuesioner. Hasil Hubungan antara disiplin guru dengan produktivitas guru (rX1,X2) adalah kuat dan positif, dengan demikian hipotesis Ho ditolak dan H1 diterima. Hubungan tersebut merupakan hubungan yang linier