bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Anxiety Affects Embryo Implantation Via Impairing Adrenergic Receptor Signaling in Decidual Cells
Authors: Wu Jinxiang , Lin Shu , Huang Pinxiu , Qiu Lingling , Jiang Yufei , Zhang Ying , Meng Nan , Meng Meiqing , Wang Lemeng , Deng Wenbo , Liu Zhao , Guo Chuanhui , Lu Jinhua , Wang Haibin , Kong Shuangbo 
Published: November 2021

Abstract
Psychological stress is closely related to recurrent pregnancy failure (RPF) and infertility, but the mechanism is still unclear. The human endometrium plays a vital role in providing the site for embryo implantation; many factors have been implicated in unsatisfactory endometrial receptivity in RPF. In the current study, we found that women with pregnancy loss or infertility have a higher serum epinephrine level, indicating a potential correlation between psychological stress and pregnancy failure. RNA-sequencing of the tissues from endometrial receptive phase of the normal and embryo recurrent implantation failure (RIF) and discovered that stress hormones could affect the functional status of the receptive phase of the endometrium. Subsequent analysis showed that the epinephrine signaling acts as an important regulator of endometrial receptivity through PI3K-AKT and FOXO1 signaling pathways. We also found that patients with RIF have attenuated expression of alpha-2C-adrenergic receptor (ADRA2C), and its down regulation would inhibit the promotion of adrenergic signal-mediated decidualization. We treated the early pregnancy model of stressed mice and observed that they had high serum epinephrine levels, defective uterine adrenergic receptor expression and low pregnancy rates. All together, our findings indicate that mental stress during early pregnancy can alter the functional status of endometrial receptivity.
GMDH-type Neural Networks for Predicting Financial Time Series: A Study of Informational Efficiency of Stock Markets
Authors: Jakaite L , Ciemny M , Selitskiy S , Schetinin Vitaly 
Published: November 2021

Abstract
A theory of Efficient Market Hypothesis (EMH) has been introduced by Fama to analyse financial markets. In particular the EMH theory has been proven in real cases under different conditions, including financial crises and frauds. The EMH assumes to examine the prediction accuracy of models designed on retrospective data. Such prediction models could be designed in different ways that motivated us to explore Machine Learning (ML) methods known for building models providing a high prediction performance. In this study we propose a ``deep'' learning method for building high-performance prediction models. The proposed method is based on the Group Method of Data Handling (GMDH) that is the deep learning paradigm capable of building multilayer neural-network models of a near-optimal complexity on given data. We show that the developed GMDH-type neural network has outperformed the models built by the conventional ML methods on the Warsaw Stock Exchange data. It is important that the complexity of the designed GMDH-type neural-networks is defined by the number of layers and connections between neurons. The performances of models were compared in terms of the prediction errors. We report a significantly smaller prediction error of the proposed method than that of the conventional autoregressive and "shallow’’ neural-network models. This finally allows us to conclude that traders will be advantaged by the proposed method.
Single-step additive manufacturing of silicon carbide through laser-induced phase separation
Authors: Karakoc Omer , Mao Keyou , Xi Jianqi , Koyanagi Takaaki , Liu Jian , Szlufarska Izabela , Katoh Yutai 
Published: November 2021

Abstract
Silicon carbide (SiC) tubes are fabricated through femtosecond high-energy ultra-short pulsed laser powder bed fusion (LPBF) additive manufacturing. Widespread implementation of pulsed LPBF of SiC compounds is hampered by a poor understanding of the material–laser interaction for such short processing times and under such extreme thermal regimes, which is due to the complexity of SiC materials. In this investigation, binding and phase separation mechanisms of SiC powders driven by pulsed laser–material interactions are elucidated using numerous state-of-the-art analytical tools as well as theoretical calculations. Partial disintegration of 6H-SiC powders into silicon and carbon during laser sintering is demonstrated to bind SiC powder particles together with no measurable SiO2 phase formation. During femtosecond laser–material interactions, 6H-SiC decomposes into silicon and carbon at high temperatures and localized high pressure state on the process. Decomposition of 6H-SiC is corroborated by density functional theory (DFT) calculations. Furthermore, relatively large (~200 nm–1.5 µm) pockets of 6H-SiC, 3C-SiC, repetitive nanoscale-pattern “nanobreathing” (~2–20 nm) of 6H-SiC and highly oriented pyrolytic graphite spheres are formed. The experimental observations indicate the viability of the synthesis of highly oriented spheroidal pyrolytic graphite and 3C-SiC and 6H-SiC grains, and thin elements of silicon and carbon, using high energy short-pulse laser irradiation.
Mortality from snakebite envenomation: an analysis from the Global Burden of Disease Study 2019
Authors: Roberts Nicholas , Johnson Emily , Zeng Scott , Hamilton Erin , Abdoli Amir , Alahdab Fares , Alipour Vahid , Ancuceanu Robert , Andrei Catalina , Anvari Davood , Arabloo Jalal , Ausloos Marcel , Awedew Atalel , Badiye Ashish , Bakkannavar Shankar , Bhalla Ashish , Bhardwaj Nikha , Bhardwaj Pankaj , Bhaumik Soumyadeep , Bijani Ali , Boloor Archith , Cai Tianji , Carvalho Felix , Chu Dinh Toi , Couto Rosa , Dai Xiaochen , Desta Abebaw , Do Hoa , Earl Lucas , Eftekhari Aziz , Esmaeilzadeh Firooz , Farzadfar Farshad , Fernandes Eduarda , Filip Irina , Foroutan Masoud , Franklin Richard , Gaidhane Abhay , Gebregiorgis Birhan , Gebremichael Berhe , Ghashghaee Ahmad , Golechha Mahaveer , Hamidi Samer , Haque Syed , Hayat Khezar , Herteliu Claudiu , Ilesanmi Olayinka , Islam M Mofizul , Jagnoor Jagnoor , Kanchan Tanuj , Kapoor Neeti , Khan Ejaz , Khatib Mahalaqua , Khundkar Roba , Krishan Kewal , Kumar G Anil , Kumar Nithin , Landires Iván , Lim Stephen , Madadin Mohammed , Maled Venkatesh , Manafi Navid , Marczak Laurie , Menezes Ritesh , Meretoja Tuomo , Miller Ted , Mohammadian-Hafshejani Abdollah , Mokdad Ali , Monteiro Francis , Moradi Maryam , Nayak Vinod , Nguyen Cuong , Nguyen Huong , Nuñez-Samudio Virginia , Ostroff Samuel , Padubidri Jagadish , Pham Hai , Pinheiro Marina , Pirestani Majid , Syed Zahiruddin , Rabiee Navid , Radfar Amir , Rahimi-Movaghar Vafa , Rao Sowmya , Rastogi Prateek , Rawaf David , Rawaf Salman , Reiner Robert , Sahebkar Amirhossein , Samy Abdallah , Sawhney Monika , Schwebel David , Senthilkumaran Subramanian , Shaikh Masood , Skryabin Valentin , Skryabina Anna , Soheili Amin , Stokes Mark , Thapar Rekha , Tovani-Palone Marcos , Tran Bach , Travillian Ravensara , Velazquez Diana , Zhang Zhi-Jiang , Naghavi Mohsen , Dandona Rakhi , Dandona Lalit , James Spencer , Pigott David , Murray Christopher , Hay Simon , Vos Theo , Ong Kanyin 
Published: November 2021

Abstract
Venomous snakebite is an important cause of preventable death. The World Health Organization (WHO) set a goal to halve snakebite mortality by 2030. We used verbal autopsy and vital registration data to model the proportion of venomous animal deaths due to snakes by location, age, year, and sex, and applied these proportions to venomous animal contact mortality estimates from the Global Burden of Disease 2019 study. In 2019, 63,400 people (95% uncertainty interval 38,900–78,600) died globally from snakebites, which was equal to an age-standardized mortality rate (ASMR) of 0.8 deaths (0.5–1.0) per 100,000 and represents a 36% (2–49) decrease in ASMR since 1990. India had the greatest number of deaths in 2019, equal to an ASMR of 4.0 per 100,000 (2.3-5.0). We forecast mortality will continue to decline, but not sufficiently to meet the WHO’s goals. Improved data collection should be prioritized to help target interventions, improve burden estimation, and monitor progress.
CXCL13 Correlates with Prognosis, Immune Infiltration, and T Cell Exhaustion in Ovarian Cancer
Authors: Duan Hailing , Lv Ying , Liao Pan , Wang Yiming , Zheng Zhifang , Qu Honglan 
Published: November 2021

Abstract
Background: CXCL13 is an important chemotactic factor closely related to the biology of cancer cells. The presence work focused on exploring the significance of CXCL13 in prognosis prediction and analyzing the associations of CXCL13 with T cell function and immune infiltration in various cancers, especially ovarian cancer (OV).Purpose: CXCL13 is associated with prognosis, immune infiltration, and T cell failure of ovarian cancer.Methods: The Oncomine, GEPIA2 and HPA databases were utilized for analyzing CXCL13 levels within diverse cancers. The significance of CXCL13 in prognosis prediction was explored through Kaplan-Meier Plotter, TCGAportal, and GEPIA2. Meanwhile, the associations of CXCL13 with clinical stage, gene marker sets, and immune infiltration were examined through TISIDB, GEPIA2, and TIMER databases. Besides, CXCL13 was screened to analyze the biological processes (BPs) and KEGGs enriched by co-expression genes. The miRWalk database was employed for analyzing the gene-miRNA interaction network of CXCL13 within OV.Results: CXCL13 expression decreased in many cancers, which predicted the dismal survival of OV. CXCL13 upregulation was in direct proportion to the increased immune infiltration degrees of many functional T cells (like exhausted T cells) and immune cells. Additionally, some critical genes of exhausted T cells, such as TIM-3, PD-1, LAG3, TIGIT, GZMB, and CXCL13, were closely associated with CXCL13. Moreover, CXCL13 was related to immune response regulatory signaling pathway, leukocyte cell-cell adhesion, cell adhesion molecules (CAMs), and hematopoietic cell lineage. Conclusion: CXCL13 can serve as a biomarker to predict cancer prognosis, particularly OV. CXCL13 upregulation remarkably elevates the immune infiltration degrees of numerous immune cells, like mast cells, CD8+ T cells, natural killer (NK) cells, and dendritic cells (DCs). Furthermore, CXCL13 is suggested to be closely related to exhausted T cells, which may be used as a candidate regulating factor for T cell exhaustion within OV. Detecting CXCL13 levels contributes to prognosis prediction and CXCL13 regulation within exhausted T cells, which provides a new approach to maximizing the anti-OV efficacy of immunotherapy.
Validating Field Regeneration Capacity for Selected Accessions of Gossypium hirsutum Using Callus Induction and Regeneration Capacity
Authors: Tajo Sani Muhammad , Pan Zhao , Sadau Salisu Bello , Iqbal Shahid , Yusuf KM , Chen Baojun , Hu Daowu , Wang Liru , Mehari Teame Gereziher , Ajadi Abolare Adijat , Bello Babatunde Kazeem , Sammani Tajo , Mahmood Tahir , Sale Ali Ibrahim , Auta Umar , Geng Xiaoli , Du Xiongming 
Published: November 2021

Abstract
Gossypium hirsutm undergoes a rapid clonal propagation to regenerate a mature plant through tissue culture. In this research, cotton leaf regeneration level for 21 accessions in the field (new leaves) was observed after the first harvest, and a comparison between field regeneration level and callus induction with its regeneration capacity (new shoots and roots) for the same 21 accessions was carried out. During the flowering stage of Gossypium hirsutum, biochemical (Proline), physiological (chlorophyll and carotenoid content) analysis was carried out. Phenotypic observations (plant height, leaf area, fresh leaf weight, dry leaf weight, flower and boll number) were also carried out on 21 accessions for each accession. Callus induction and regeneration capacity of roots and shoots for hypocotyl, cotyledons and shoot tip tissues was used to validate field regeneration capacity through analysis of variance. ZS061, LuMian378, JiMian863, and ZS065 have highest drought tolerance while ZhongMianSuo24, LiaoYangDuoMaoMian, and BeiZheGongSheMian have the lowest tolerance to drought stress. Accessions with both field and callus regeneration capacity were identified.
C -reactive protein promotes tumor progression in Hepatocellular Carcinom by 1 interacting with Ephrin type B receptor 3
Authors: Yang Yi Xuan , She Sha , Yang Min , Li Shi Ying , Hu Huai Dong , Ren Hong 
Published: November 2021

Abstract
C-reactive protein (CRP), an acute phase protein, has been increasingly implicated in various tumors, and the role of CRP is positively correlated with invasion and metastasis in hepatocellular carcinoma cells. However, the mechanism of CRP affecting HCC progression remains poorly investigated. The present study investigated the role of CRP in HCC and the underlying mechanisms. We first found that CRP was significantly upregulated in HCC tissues and HCC cells, the expression level correlated with the metastatic ability of HCC cells. Knockdown of CRP significantly suppresses migration and invasion capacity in HCC cells. Through a proteomic analysis of CRP co-immunoprecipitation complexes, the Eph receptor B3 was identified as a new CRP interactor. Then we found that the expression and functions of EphB3 were consistent with CRP in HCC. In addition, co-immunoprecipitation and immunofluorescence assays suggested that EphB3 was able to interact with MAPK/ERK to activate MAPK/ERK signaling pathways. Furthermore, we showed that CRP can induce the phosphorylation of MAPK/ERK by binding EphB3. Our findings showed that CRP increased HCC cells migration and invasion by binding EphB3 to activate MAPK/ERK signaling pathways. It suggested that CRP may become a prognostic factor and a potential therapeutic target for liver cancer.
U-shaped Association Between Apolipoprotein B and All-Cause Mortality: Results from the National Health and Nutrition Examination Surveys
Authors: yan mengqi , Liu Xiaocong , Huang Yuqing , Yu Yuling , Zhou Dan , Feng Yingqing 
Published: November 2021

Abstract
BackgroundApolipoprotein B (apoB), a significant component directly reflecting the number of atherogenic lipoprotein particles, gradually becomes a more conducive indicator to control blood lipids. However, epidemiological evidence on its relationship with mortality is limited, especially with all-cause mortality. MethodsParticipants from the National Health and Nutrition Examination Survey during 2007-2014 were grouped according to the apoB quartiles (15-76, 77-92, 93-110, 111-345mg/dL). We performed Cox proportional hazards models and Kaplan-Meier survival curves to evaluate the relationships of apoB with all-cause and cardiovascular mortality. Restricted cubic spline and piecewise linear regression were performed to detect their non-linear relationships. ResultsIn general, we enrolled 10375 participants among United States adults (mean age 46.3 ± 16.9, 47.88% men). On average, participants were followed up for 69.2 months, among whom 533 (5.14%) and 91 (0.88%) deaths were observed due to all -causes and cardiovascular diseases, respectively. After adjusting for confounders, apoB was independently associated with an elevated risk of cardiovascular death (hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.03-1.24). However, in the third quartile of apoB, the risk of all-cause death decreased significantly (HR, 0.71; 95% CI, 0.56-0.91). Moreover, the non-linear relationship between apoB and all-cause death demonstrated an increased risk at both low and high level apoB concentrations, divided by the threshold point of 108 mg/dl. Conclusion﻿Elevated apoB was significantly associated with an increased risk for cardiovascular mortality, while its association with all-cause mortality was non-linear correlated, with an increased risk at both low and high apoB levels.
Effect of Foliar Spraying of Organic and Inorganic Selenium Fertilizers On Selenium Accumulation and Speciation During Different Stages of Rice Growth
Authors: Yuan Zhengqing , Long Weixiong , Liang Ting , Zhu Menghan , Luo Xiaoyun , Fu Lu , Hu Zhongli , Zhu Renshan , Wu Xianting 
Published: November 2021

Abstract
Aims

Most crops are supplemented with selenium (Se) through the exogenous addition of inorganic selenium fertilizer. There is a lack of in-depth research on organic selenium fertilizers. Meanwhile, the dosage range between human selenium deficiency and selenium toxicity is narrow, so the selenium content of agricultural products needs to be controlled within a reasonable interval.
Methods W

e analyzed and compared the Se accumulation and speciation in rice during three different growth stages (late tillering stage, initiate heading stage, and full heading stage) using three selenium fertilizers, selenite, fermented Se, and potassium Selenocyanoacetate (Se-AAF) via the foliar application.
Results

The selenium content in rice sprayed with organic selenium fertilizer was controlled in the relatively safe range and met the human selenium supplement requirement compared to the sprayed sodium selenite, which was too high of a dose. The percentage of organic Se and protein Se in brown rice was found to be similar in all three Se fertilizers. The highest organic selenium content of 91.57% was found in the grain of rice at the full heading stage by spraying Se-AAF. The main Se species in the grain was selenomethionine (SeMet), which reached 80% of the total selenium. Se-methyl selenocysteine(SeMeCys) was found only in Se-AAF. The grain quality showed that all three Se fertilizers increased the consistency of gelatinization.
Conclusions

Appropriately delaying the spraying time and selecting organic Se fertilizer as the Se source can help to produce green and safe selenium-rich rice.
On the Tribological Properties of RGO-MoS2 Composites Surface Modified by Oleic Acid
Authors: LIU TianXia , Qin jian , Wang Jian , Li jing 
Published: November 2021

Abstract
Purpose To study the effect of oleic acid surface modified RGO/MoS2 composite lubricating additives on the friction and wear properties of 10# White Oil (10# WO). Method The influence of different concentrations of reduction graphene oxide/molybdenum disulfide (RGO-MoS2) and oleic acid surface modified reduction graphene oxide/molybdenum disulfide (OA-RGO-MoS2) on the lubricating properties in 10# WO was investigated by using a four-ball long-term friction and wear tester. The microscopic morphology, lattice structure, composition and element valence of the prepared material were characterized by scanning electron microscope, Raman spectroscopy, X-ray diffractometer, X-ray photoelectron spectroscopy, element analyzer and other instruments. The diameter, structure, morphology, composition and element valence state of the wear scar were obtained by multifunctional universal tool microscope, scanning electron microscope and X-ray photoelectron spectroscopy. Result In the RGO-MoS2 white oil system, when 0.4 wt% RGO-MoS2 was added, the anti-friction effect was the best, and the average friction coefficient (AFC) reduced by 21.8%. When 0.2 wt% RGO-MoS2 was added, the anti-wear effect was the optimal, and the average wear scar diameter (AWSD) decreased by 12.4%. In the OA-RGO-MoS2 white oil system, when 0.2 wt% OA-RGO-MoS2 was added, the anti-friction and anti-wear effects were the best, and the AFC reduced by 33.3%, and AWSD reduced by 14.1%. Conclusion Compared with RGO-MoS2, OA-RGO-MoS2 has a higher degree of graphitization, larger interlayer spacing, lower degree of layered accumulation, higher MoS2 load, and weaker thermal stability. Both lubricating additives have good anti-friction and anti-wear effects at low concentrations, and the anti-friction and anti-wear effects are more prominent after being modified by oleic acid. Analysis of friction mechanism shows that a lubricating protective film containing iron, oxygen, molybdenum, carbon, and sulfur is formed through adsorption or tribochemical reaction during the friction process, which improves the lubrication state and plays a role in reducing friction and anti-wear.
Determinants of Clinician and Patient to prescription of antimicrobials: case of Mulanje, Southern Malawi
Authors: Chalusa Morris , Khuluza Felix , Bandawe Chiwoza 
Published: November 2021

Abstract
BackgroundAntimicrobial resistance is an emerging problem in low- and middle-income countries. The problem is exacerbated by inappropriate prescription of antimicrobials. Factors leading to overuse or inappropriate prescription of antimicrobials by the cadre of medical assistants, clinical technicians and clinical officers have received limited attention. This study investigated factors that influence prescription behaviours of antimicrobials among clinical officers in various health facilities in Mulanje district, Southern Malawi. MethodsIn-depth interviews (n=18) and focus group discussions (n=2) were conducted with COs from four health facilities in Mulanje district. Purposive sampling was done to arrive at a sample size of 30 health cadres. ResultsParticipants pointed out that patient preferences, belief and clinicians’ inadequate education on this issue were among the factors that contribute to inappropriate antimicrobial prescription. 75-% of clinicians showed lack of knowledge on the definition of antibiotic and antimicrobial resistance. ConclusionInappropriate use of antimicrobials is facilitated by prescribing decisions made by clinicians who are greatly influenced by their patients. Interventions aimed at improving antimicrobial prescription should target both clinicians and patients.
Therortical Studies and Investagting of Selected Potnet CDK2 Inhibitors as Anticancer Agents
Authors: Abunuwar Mohammad J , Dahadha Adnan A 
Published: November 2021

Abstract
In this study eight selected of the most potent cyclin dependent kinase 2 inhibitors in which targeting adenosine triphosphate -pocket site theoretically investigated to support literature information of frontier molecular orbitals, molecular electrostatic maps, and global chemical reactivity descriptors such as chemical hardness, chemical softness, chemical potential, electronegativity and electrophilicity of cyclin dependent kinase 2 inhibitors. Calculation and three-dimensional plotting were achieved through Gaussian 09W and Gausview 6 software’s utilizing density functional theory quantum modeling applying both hybrids extended and not extended basis set. Crystal structure of CDK2 with inhibitors was obtained from protein data bank and visualized through PyMol Schrödinger software to assign polar and non-polar interactions of inhibitors with enzyme. A promising conclusion trend obtained in this research regarding to molecules that could have an inhibition activity toward the cyclin dependent kinase 2 enzymes. Our theoretical investigation emphasizes that, the anti-cancer activity has directly relationship with value of chemical hardness and chemical softness, where the most potent compounds was the pyrazolopyrimidine and imidazole pyrimidine and they have higher chemical hardness value and at the same time lower value of chemical softness compared with the rest of compounds.
Optimization for Morphology of Grinding Layer on Textured Laser Cladding Grinding Tool
Authors: Zhao Xufeng , Li Changhe , Yu Tianbiao 
Published: November 2021

Abstract
In order to improving the grinding performance of laser cladding textured grinding tool (LCTGT) under high speed grinding process, the topography shape (height, width and height/width ratio) of laser cladding grinding layers on LCTGT were designed with RSM (response surface method) through optimizing laser cladding processing parameters and laser cladding layers structure parameters that based on Archimedes helix coefficients. The LCTGTs were produced with optimized laser cladding parameters and structural parameters for laser cladding grinding layers. The results showed that laser cladding parameters of 397W of laser power, 3.56 mm/s of the laser scanning speed and 0.91 r/min of powder feeding rate and structure parameters of laser cladding layers of 6-10-10 can meet requirement.