bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Escola Nova”: The New Secondary School in Mozambique
Authors: Searle Chris 
Published: August 2021

Our schools, our syllabuses, our independence—without which we would not be here—are the fruit of scarifice, of the struggle of generations of our ancestors, of our grandparents, of our parents. They are the fruit of Revolution.To the students we say: you are those who continue the Revolution. We leave in you all our hopes, the hopes of the future of our country. But in order that you can continue the Revolution, you must assume the deep significance of your mission as students. You must understand that the school where you study is the fruit of the blood of sacrifice of our People.
What Rough Beast: Neo-African Literature and the Force of Social Change
Authors: Cook William 
Published: August 2021

The Second ComingTurning and turning in the widening gyreThe falcon cannot hear the falconer;Things fall apart; the centre cannot hold;Mere anarchy is loosed upon the world,The blood-dimmed tide is loosed, and everywhere 5The ceremony of innocence is drowned;The best lack all conviction, while the worstAre full of passionate intensity.Surely some revelation is at hand;Surely the Second Coming is at hand. 10The Second Comingl Hardly are those words outWhen a vast image out of Spiritus MundiTroubles my sight: somewhere in sands of the desertA shape with lion body and the head of a man,A gaze blank and pitiless as the sun, 15Is moving its slow thighs, while all about itReel shadows of the indignant desert birds.The darkness drops again; but I knowThat twenty centuries of stony sleepWere vexed to nightmare by a rocking cradle, 20And what rough beast, its hour come round at last,Slouches towards Bethlehem to be born?William Butler YeatsChinua Achebe in 1959 turned to the above poem by Yeats, with its prophecy of the approach of a new age, for the title to his first novel. Ezekiel Mphalhlele in the same year chose lines seven and eight of the same powm as the epigraph to his autobiographical Down Second Avenue. This convergence upon one of the most foreboding images in modern poetry is not an accident. Both writers saw their own experiences of loss of order and future debilitation confirmed within the lines of Yeat’s apocalyptic poem. Viewed within the context of Yeats’ theory of 2000-year gyres, this vision becomes even more ominous.
Zimbabwe Urged to Close Rich-Poor Gap: Riddell Commission Would Raise Minimum Wages, Taxes on Rich
Authors: Hawkins Tony 
Published: August 2021

Major structural changes in the Zimbabwean economy to alleviate poverty and reduce income inequalities are recommended in the bold and forward-looking report of the Riddell commission of inquiry into incomes, prices, and conditions of service.The 330-page report of the nine-member commission published here recently offers a broadly-based package of policy recommendations, including higher minimum wages, increased taxes on companies and better-paid individuals, reform of the industrial relations system, substantially more land and better credit and marketing facilities for peasant farmers, the squeezing of pay differentials, and a gradual phasing out of food subsidies.
Human Rights Violations in Ethiopia: The Case for Permanent Adjustment of Immigration Status for Ethiopians in the United States
Authors:   The Ethiopian Committee on Immigration
Published: August 2021

Ethiopia is one of the oldest countries in the world. Except for a brief five year period of Italian occupation (1936-41), Ethiopia, in the span of its thousands of years of existence, was never conquered and administered by a foreign power. Therefore, the tradition of permanent emigration or seeking asylum in foreign countries is an alien concept to the Ethiopian people.Ancient and medieval Ethiopia is depicted as having existed in isolation from contemporaneous states and empires. This attribution of isolationism, compactly expressed by Edward Gibbon’s oft quoted statement that “the Ethiopians slept nearly a thousand years, forgetful of the world by whom they were forgotten,” is not at all borne by historical facts.
A toolkit of methods of development-focused health technology assessment
Authors: Bouttell Janet , Briggs Andrew , Hawkins Neil 
Published: August 2021

AbstractHealth technology assessment conducted to inform decisions during technology development (development-focused or DF-HTA) has a number of distinct features compared with HTA conducted to inform reimbursement and usage decisions. In particular, there are a broad range of decisions to be informed related to the development of a technology; multiple markets and decision makers to be considered; a limited (and developing) evidence base; and constrained resources for analysis. These features impact upon methods adopted by analysts. In this paper, we (i) set out methods of DF-HTA against a timeline of technology development; (ii) provide examples of the methods’ use; and (iii) explain how they have been adapted as a result of the features of DF-HTA. We present a toolkit of methods for analysts working with developers of medical technologies. Three categories of methods are described: literature review, stakeholder consultation, and decision analytic modeling. Literature review and stakeholder consultation are often used to fill evidence gaps. Decision analytic modeling is used to synthesize available evidence alongside plausible assumptions to inform developers about price or performance requirements. Methods increase in formality and complexity as the development and evidence base progresses and more resources are available for assessment. We hope this toolkit will be used in conjunction with the framework of features of DF-HTA presented in our earlier article in order to improve the clarity and appropriateness of methods of HTA used in DF-HTA. We also seek to contribute to a continuing dialogue about the nature of, and the best approach to, DF-HTA.
The 1982 Voting Rights Act Extension as a “Critical Juncture”: Ronald Reagan, Bob Dole, and Republican Party-Building
Authors: Johnson Richard 
Published: August 2021

AbstractRepublican support for the 1982 Voting Rights Act (VRA) extension is a puzzle for scholars of racial policy coalitions. The extension contained provisions that were manifestly antithetical to core principles of the “color-blind” policy alliance said to dominate the GOP. Recent scholarship has explained this puzzling decision by arguing that conservatives were confident that the VRA's most objectionable provisions could be undone by the federal bureaucracy and judiciary, while absolving Republicans of the blame of being against voting rights. This article suggests that the picture is more complicated. Applying the concept of “critical junctures” to the 1982 VRA extension, the article highlights the importance of actors’ contingent decisions and reveals a wider range of choices available to political entrepreneurs than has been conventionally understood. Highlighting differing views within the Reagan administration, this article also identifies a wider range of reasons why Republicans supported the act's extension, including career ambition, party-building, policy agenda advancement, and genuine commitment, rather than simply a defensive stance as implied by recent histories.
Stress reactivity and social cognition in pure and co-occurring early childhood relational bullying and victimization
Authors: Perhamus Gretchen R. , Perry Kristin J. , Murray-Close Dianna , Ostrov Jamie M. 
Published: August 2021

AbstractThis study tested the independent effects and interactions of sympathetic nervous system reactivity and hostile attribution biases (HAB) in predicting change in pure and co-occurring relational bullying and victimization experiences over one year. Co-occurring and pure relational bullying and victimization experiences were measured using a dimensional bifactor model, aiming to address methodological limitations of categorical approaches, using data from 300 preschoolers (Mage = 44.70 months, SD = 4.38). Factor scores were then saved and used in nested path analyses with a subset of participants (n = 81) to test main study hypotheses regarding effects of HAB and skin conductance level reactivity (SCL-R). Bifactor models provided good fit to the data at two independent time points. HAB and SCL-R interacted to predict increases in co-occurring relational bullying/victimization with evidence for over- and underarousal pathways.
The Change in Geomechanical Properties of Gas Saturated Methane Hydrate‐Bearing Sand Resulting From Water Saturation
Authors: Priest J. A. , Abbas M. , Hayley J. L. 
Published: August 2021

AbstractLaboratory tests were carried out on gas‐saturated hydrate‐bearing sand (HBS) specimens that were subsequently water saturated to determine the influence of water saturation on their small‐strain (stiffness) and large‐strain (strength) behavior. Hydrate formed using the “excess gas” method led to significant increases in stiffness and strength of the sand. The magnitude increase in stiffness was largest for the lowest hydrate saturation tests and was sensitive to the distribution of hydrate within the sand. In contrast, increases in strength were directly related to increases in hydrate saturation, and to a lesser extent, on the applied confining stresses. Subsequent water saturation of these gas‐saturated HBS (achieved by flushing up to three times the pore volume of water through the HBS specimen) led to ∼90% and ∼70% reduction in stiffness and strength, respectively, along with a 37% reduction in hydrate volume (initial hydrate pore saturation ∼21.5%). Specimens with higher initial hydrate saturations (∼48%) saw slightly smaller reductions in stiffness and strength associated with ∼17% reduction in hydrate saturation. Changes in behavior appear to be related to the reduction of “cementing” hydrate at particle contacts through dissociation/dissolution of the hydrate, with remaining hydrate being more “pore filling.” Processes that may induce fluid flow in a natural gas‐saturated HBS, such as during the depressurization of the HBS reservoir during hydrate production, may lead to changes in hydrate morphology and affect the geomechanical properties of the HBS even when the HBS are still under hydrate stability conditions.
Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer
Authors: Sandza Krystal , Clark Annie , Koziol Elli , Akeefe Hassibullah , Yang Fan , Holcomb Jennifer , Patton Kathryn , Hammon Kevin , Mitchell Nina , Wong Wing Y. , Zoog Stephen J. , Kim Benjamin , Henshaw Joshua , Vettermann Christian 
Published: August 2021

AbstractAdeno-associated virus (AAV)-based gene therapy vectors are replication-incompetent and thus pose minimal risk for horizontal transmission or release into the environment. In studies with AAV5-FVIII-SQ (valoctocogene roxaparvovec), an investigational gene therapy for hemophilia A, residual vector DNA was detectable in blood, secreta, and excreta, but it remained unclear how long structurally intact AAV5 vector capsids were present. Since a comprehensive assessment of vector shedding is required by regulatory agencies, we developed a new method (termed iqPCR) that utilizes capsid-directed immunocapture followed by qPCR amplification of encapsidated DNA. The limit of detection for AAV5 vector capsids was 1.17E+04 and 2.33E+04 vg/mL in plasma and semen, respectively. Acceptable precision, accuracy, selectivity, and specificity were verified; up to 1.00E+09 vg/mL non-encapsidated vector DNA showed no interference. Anti-AAV5 antibody plasma concentrations above 141 ng/mL decreased AAV5 capsid quantification, suggesting that iqPCR mainly detects free capsids and not those complexed with antibodies. In a clinical study, AAV5-FVIII-SQ capsids were found in plasma and semen but became undetectable within nine weeks after dose administration. Hence, iqPCR monitors the presence and shedding kinetics of intact vector capsids following AAV gene therapy and informs the potential risk for horizontal transmission.
Chlorine activated stacking fault removal mechanism in thin film CdTe solar cells: the missing piece
Authors: Hatton Peter , Watts Michael J. , Abbas Ali , Walls John M. , Smith Roger , Goddard Pooja 
Published: August 2021

AbstractThe conversion efficiency of as-deposited, CdTe solar cells is poor and typically less than 5%. A CdCl2 activation treatment increases this to up to 22%. Studies have shown that stacking faults (SFs) are removed and the grain boundaries (GBs) are decorated with chlorine. Thus, SF removal and device efficiency are strongly correlated but whether this is direct or indirect has not been established. Here we explain the passivation responsible for the increase in efficiency but also crucially elucidate the associated SF removal mechanism. The effect of chlorine on a model system containing a SF and two GBs is investigated using density functional theory. The proposed SF removal mechanisms are feasible at the 400 ∘C treatment temperature. It is concluded that the efficiency increase is due to electronic effects in the GBs while SF removal is a by-product of the saturation of the GB with chlorine but is a key signal that sufficient chlorine is present for passivation to occur.
A novel CT scoring method predicts the prognosis of interstitial lung disease associated with anti-MDA5 positive dermatomyositis
Authors: Xu Wenwen , Wu Wanlong , Zhang Danting , Chen Zhiwei , Tao Xinwei , Zhao Jiangfeng , Wang Kaiwen , Wang Xiaodong , Zheng Yu , Ye Shuang 
Published: August 2021

AbstractAnti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+ DM-ILD) is a life-threatening disease. This study aimed to develop a novel pulmonary CT visual scoring method for assessing the prognosis of the disease, and an artificial intelligence (AI) algorithm-based analysis and an idiopathic pulmonary fibrosis (IPF)-based scoring were conducted as comparators. A retrospective cohort of hospitalized patients with MDA5+ DM-ILD was analyzed. Since most fatalities occur within the first half year of the disease course, the primary outcome was the six-month all-cause mortality since the time of admission. A ground glass opacity (GGO) and consolidation-weighted CT visual scoring model for MDA5+ DM-ILD, namely ‘MDA5 score’, was then developed with C-index values of 0.80 (95%CI 0.75–0.86) in the derivation dataset (n = 116) and 0.84 (95%CI 0.71–0.97) in the validation dataset (n = 57), respectively. While, the AI algorithm-based analysis, namely ‘AI score’, yielded C-index 0.78 (95%CI 0.72–0.84) for the derivation dataset and 0.77 (95%CI 0.64–0.90) for the validation dataset. These findings suggest that the newly derived ‘MDA5 score’ may serve as an applicable prognostic predictor for MDA5+ DM-ILD and facilitate further clinical trial design. The AI based CT quantitative analysis provided a promising solution for ILD evaluation.
Numerical simulation of the impact of an integrated renovation project on the Maowei Sea hydrodynamic environment
Authors: Wang Cui , Cai Ling , Wu Yaojian , Ouyang Yurong 
Published: August 2021

AbstractIntegrated renovation projects are important for marine ecological environment protection. Three-dimensional hydrodynamics and water quality models are developed for the Maowei Sea to assess the hydrodynamic environment base on the MIKE3 software with high resolution meshes. The results showed that the flow velocity changed minimally after the project, decreasing by approximately 0.12 m/s in the east of the Maowei Sea area and increasing by approximately 0.01 m/s in the northeast of the Shajing Port. The decrease in tidal prism (~ 2.66 × 106 m3) was attributed to land reclamation, and accounted for just 0.86% of the pre-project level. The water exchange half-life increased by approximately 1 day, implying a slightly reduced water exchange capacity. Siltation occurred mainly in the reclamation and dredging areas, amounting to back-silting of approximately 2 cm/year. Reclamation project is the main factor causing the decrease of tidal volume and weakening the hydrodynamics in Maowei Sea. Adaptive management is necessary for such a comprehensive regulation project. According to the result, we suggest that reclamation works should strictly prohibit and dredging schemes should optimize in the subsequent regulation works.
Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air–liquid interface model
Authors: Bluhmki Teresa , Traub Stefanie , Müller Ann-Kathrin , Bitzer Sarah , Schruf Eva , Bammert Marie-Therese , Leist Marcel , Gantner Florian , Garnett James P , Heilker Ralf 
Published: August 2021

AbstractIn order to circumvent the limited access and donor variability of human primary alveolar cells, directed differentiation of human pluripotent stem cells (hiPSCs) into alveolar-like cells, provides a promising tool for respiratory disease modeling and drug discovery assays. In this work, a unique, miniaturized 96-Transwell microplate system is described where hiPSC-derived alveolar-like cells were cultured at an air–liquid interface (ALI). To this end, hiPSCs were differentiated into lung epithelial progenitor cells (LPCs) and subsequently matured into a functional alveolar type 2 (AT2)-like epithelium with monolayer-like morphology. AT2-like cells cultured at the physiological ALI conditions displayed characteristics of AT2 cells with classical alveolar surfactant protein expressions and lamellar-body like structures. The integrity of the epithelial barriers between the AT2-like cells was confirmed by applying a custom-made device for 96-parallelized transepithelial electric resistance (TEER) measurements. In order to generate an IPF disease-like phenotype in vitro, the functional AT2-like cells were stimulated with cytokines and growth factors present in the alveolar tissue of IPF patients. The cytokines stimulated the secretion of pro-fibrotic biomarker proteins both on the mRNA (messenger ribonucleic acid) and protein level. Thus, the hiPSC-derived and cellular model system enables the recapitulation of certain IPF hallmarks, while paving the route towards a miniaturized medium throughput approach of pharmaceutical drug discovery.
The adsorption characteristics of Cu(II) and Zn(II) on the sediments at the mouth of a typical urban polluted river in Dianchi Lake: taking Xinhe as an example
Authors: Ma Xiang-shu , Liu Leng , Fang Yi-chuan , Sun Xiao-long 
Published: August 2021

AbstractThis study is to determine the spatial distribution characteristics of Cu and Zn adsorption on the sediments of the estuary of Dianchi Lake, as well as the composite adsorption law of Cu and Zn on combinations of sediment organic matter, metal oxides, and organic–inorganic composites. The relationship between the adsorption contribution of each component of the substance. A static adsorption experiment was applied to the sediments in the estuary of Dianchi Lake. The relationship between adsorption capacity and sediment composition was analyzed through correlation analysis and redundant analysis. The results show that along the direction of the river flow and the vertical depth, the adsorption capacity presents a relatively obvious spatial distribution law; the change trend of sediment component content is not the same as the change trend of Cu and Zn adsorption capacity. The change trend of the sediment component content is not the same as the change trend of the adsorption amount of Cu and Zn, and the compound effect between the components affects the adsorption amount. The adsorption of Cu by the four groups of sediments after different treatments is more in line with the Freundlich isotherm adsorption model; When adsorbing Zn, the untreated and removed organic matter and iron-aluminum oxide group are in good agreement with the Freundlich model, while the organic matter-removed group and the iron-aluminum oxide removal group are more consistent with the Langmuir isotherm adsorption model; The adsorption contribution rate of organic–inorganic composites in sediments is not a simple addition of organic matter and iron-aluminum oxides, but a more complex quantitative relationship.
Impact of severe hypoglycemia on the heat shock and related protein response
Authors: Atkin Alexander S. , Moin Abu Saleh Md , Nandakumar Manjula , Al-Qaissi Ahmed , Sathyapalan Thozhukat , Atkin Stephen L. , Butler Alexandra E. 
Published: August 2021

AbstractHeat shock proteins contribute to diabetes-induced complications and are affected by glycemic control. Our hypothesis was that hypoglycemia-induced heat shock and related protein changes would be amplified in type 2 diabetes (T2D). This prospective, case–control study enrolled 23 T2D patients and 23 control subjects who underwent hyperinsulinemic-induced hypoglycemia (≤ 2.0 mmol/L (36 mg/dl)) with blood sampling at baseline, at hypoglycemia and after a 24-h post-hypoglycemia follow-up period. Proteomic analysis of heat shock-related and pro-inflammatory proteins was performed. At baseline, MAPKAPK5 (p = 0.02) and UBE2G2 (p = 0.003) were elevated and STUB1 decreased (p = 0.007) in T2D. At hypoglycemia: PPP3CA (p < 0.03) was increased and EPHA2 (p = 0.01) reduced in T2D; by contrast, three proteins were reduced in controls [HSPA1A (p = 0.007), HSPB1 (p < 0.02), SMAD3 (p = 0.005)] while only MAPKAPK5 was elevated (p = 0.02). In the post-hypoglycemia follow-up period, most proteins normalized to baseline by 24-h; however, STIP1 (p = 0.003), UBE2N (p = 0.004) and UBE2L3 (p < 0.04) were decreased in controls at 24-h. No protein differed from baseline at 24-h in T2D. Pro-inflammatory interleukin-6 increased at 4-h post-hypoglycemia in controls and T2D (p < 0.05 and p < 0.003, respectively) and correlated with HSPA1A; anti-inflammatory IL-10 decreased 2-h post-hypoglycemia in T2D only. Other pro-inflammatory proteins, IL-1α, IFN-γ and TNF-α, were unchanged. Heat shock and related proteins differed at baseline between T2D and controls, with an exaggerated response of heat shock and related proteins to hypoglycemia that returned to baseline, though with changes at 24-h in controls alone. An increase in pro-inflammatory IL-6, with a decrease in anti-inflammatory IL-10, suggests that the HSP system is overactivated due to underlying inflammation in T2D.Trial registration: ClinicalTrials.gov NCT03102801.
Sustainable production of graphene from petroleum coke using electrochemical exfoliation
Authors: Saha Sanjit , Lakhe Pritishma , Mason Matthew J. , Coleman Bryan J. , Arole Kailash , Zhao Xiaofei , Yakovlev Sergey , Uppili Sundararajan , Green Micah J. , Hule Rohan A. 
Published: August 2021

AbstractPetroleum coke is a solid, carbonaceous by-product of oil refining and is normally used for heating or as an anode in aluminum and steel production. These applications contribute to carbon emissions, but here we show that petroleum coke has another potential avenue: as a precursor for graphene production. This path presents an environmentally and economically sustainable use for a low-value industrial stream. Electrochemical exfoliation is used to produce graphene nanosheets from petroleum coke, rather than graphite. The final product is separated from the unreacted material by a two-step centrifuging process. SEM and TEM images confirm that the final product contains few-layered nanosheets, and the Raman spectra confirm that the exfoliated coke product is indeed graphene. Post-annealing of this product substantially increases the electrical conductivity. This new finding holds potential for the petroleum industry to produce a value-added nanomaterial and enhance the economic impact of slurry oil and slurry oil-derived coke streams by orders of magnitude; this route also allows these streams to be directed away from high-emissions uses.