bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlated Physical and Mental Health Composite Scores For the RAND-36 and RAND-12 Health Surveys: Can We Keep Them Simple?
Authors: Andersen John Roger , Breivik Kyrre , Engelund Inger Elise , Iversen Marjolein M. , Kirkeleit Jorunn , Norekvål Tone Merete , Oterhals Kjersti , Storesund Anette 
Published: October 2021

Abstract
BackgroundThe RAND-36 and RAND-12 (equivalent to versions 1 of the Short-form-36 and Short-form-12 respectively) are widely used measures of health-related quality of life. However, there are diverging views regarding how to create the physical health and mental health composite scores of these questionnaires. We present a simple approach using an unweighted linear combination of subscale scores for constructing composite scores for physical and mental health that assumes these scores should be free to correlate. The aim of this study was to investigate the criterion validity and convergent validity of these scores. MethodsWe investigated oblique and unweighted RAND-36/12 composite scores from a random sample of the general Norwegian population (N=2107). Criterion validity was tested by examining the correlation between unweighted composite scores and weighted scores derived from oblique principal component analysis. Convergent validity was examined by analysing the associations between the different composite scores, age, gender, body mass index, physical activity, rheumatic disease, and depression. ResultsThe correlations between the composite scores derived by the two methods were substantial (r = 0.97 to 0.99) for both the RAND-36 and RAND-12. The effect sizes of the associations between the oblique versus the unweighted composite scores and other variables had comparable magnitudes. ConclusionThe unweighted RAND-36 and RAND-12 composite scores demonstrated satisfactory criterion validity and convergent validity. This suggests that if the physical and mental composite scores are free to be correlated, the calculation of these composite scores can be kept simple.
Methods and Profitability of Fish Hatchery Enterprise in India
Authors: DUTTA DEBASHIS 
Published: October 2021

Abstract
Enterprise is the key foundation for any start-up or business as it provides scopes to the economic growth of individuals as well as the countries. A fish hatchery is a reliable enterprise with a sustainable good economic return. To maintain the proper and timely supply of the spawns to the fisheries industries the hatcheries should perform their activities over the year. A study in the West Bengal state of India shows that a substantial economic return can be obtained from a fish hatchery. It was also seen that the benefit-cost ratio is also greater than one (1.73). Though further research scope and enhancement of technologies can strengthen the enterprise with more profitability.
Does imbalance in chest X-ray datasets produce biased deep learning approaches for COVID-19 screening?
Authors: Alvarez-Rodríguez Lorena , de Moura Joaquim , Novo Jorge , Ortega Marcos 
Published: October 2021

Abstract
Background: The health crisis resulting from the global COVID-19 pandemic highlighted more than ever the need for rapid, reliable and safe methods of diagnosis and monitoring of respiratory diseases. To study pulmonary involvement in detail, one of the most common resources is the use different lung imaging modalities (like chest radiography) to explore the possible affected areas. Methods: In this work, we performed a comprehensive analysis of sex and age factors in chest X-ray images. The study of these recurrent patient characteristics in pathologies of this type is crucial, since there is a clear scarcity of data that may lead to biases when trying to develop systems that are as representative as possible, as well as to gain knowledge of the disease itself. To identify possible biases, we analyzed 3 different computational approaches for automatic COVID-19 screening: Normal vs COVID-19, Pneumonia vs COVID-19 and Non-COVID-19 vs COVID-19. The presented study was validated using two public chest X-ray datasets, allowing a reliable analysis to support the clinical decision-making process in the context of this dramatic global pandemic. Results: The obtained results for the sex-related imbalance analysis indicate that this factor slightly affects the system performance in the Normal VS COVID-19 and Pneumonia VS COVID-19 approaches, although the identified differences are not relevant enough to worsen considerably the system’s response. Regarding the age-related imbalance analysis, this factor was observed to be again influencing the system in a more consistent way than the sex factor, as it was present in all the approaches. Once again, this worsening is not a major problem for our data and system, as it is not of great magnitude. Conclusions: Multiple studies have been conducted in other fields in order to determine if certain patient characteristics such as sex or age influenced these deep learning systems. However, to the best of our knowledge, this study has not been done for COVID-19 despite the urgency and lack of COVID-19 chest x-ray images. The presented results evidenced that the proposed methodology and tested approaches allow a robust and reliable analysis to support the clinical decision-making process in this pandemic scenario.
Decline of sediment transport due to damming and eco-engineering is approaching its limits
Authors: Li Boyan , Wang Yunchen , Wang Chao , Wang Wei , Lin Aiwen , Daily Gretchen 
Published: October 2021

Abstract
Sediment transport from rivers to ocean is increasingly influenced by climate change and intensive human activities1, constituting a research priority of global relevance2. However, little attention has been paid to quantify and predict the contribution of driving factors to the sediment load. By integrating local-scale hydrologic modeling with soil erosion estimation model, and the soil erosion and sediment yield balance equation, we quantify watershed-scale changes in sediment load under forecasted climate change and human activities in the Yangtze River Basin (YRB), China. We also develop a new metric, the sediment load sensitivity index, that identifies sensitive to anthropogenic variability over the past 30 years. It was found that the reservoirs deposition was the primary factor (81.37 %) among human activities contributing to the decline in sediment load, followed by the soil and water conservation measures (SWCM) (18.63 %). The sediment load shows a slight increasing trend for the 1.5 °C and 2.0 °C global warming at 2020–2039 and 2040–2059, respectively. Climate change dominates the sediment load trend in the future due to the effectiveness of dams and reservoirs decreases and the saturation of the capacity of the SWCM to capture sediment. Although these findings indicate the importance of the impact of climate change on changes in sediment load, it is necessary to apply them to appropriate management to adapt to climate changes in future river basin management policies.
Morphology Changes in the Cochlea of Impulse Noiseinduced Hidden Hearing Loss
Authors: Qi Guo-wei , Shi Lei , Qin Han-dai , Zhu Yuhua , Jiang Qing-qing , Guo Wei-wei , Yu Ning , yang shi-ming 
Published: October 2021

Abstract
Objectives: This study was designed to determine the morphology changes of noise-induced hidden hearing loss (NIHHL). Method: Fifteen guinea pigs were divided into three groups: noise-induced hidden hearing loss (NIHHL) group, noise-induced hearing loss (NIHL) group, and normal control group. For the noise-induced hidden hearing loss group, the guinea pigs were exposed to 15 times of impulse noise at one time. For the noise-induced hearing loss group, the animals were exposed to a total of 200 times of impulse noise in two times, and the time interval is 24 hours. Auditory brain response (ABR) was tested before, immediately, 24h, 1week, and one month after noise exposure to evaluate cochlear physiology changes. One month after noise exposure, all guinea pigs in three groups were sacrificed, and basement membranes were carefully dissected immediately after ABR tests. The cochlea samples were observed by transmission electron microscopy (TEM) to found out the monograph changes. Result: The ABR results showed that 15 times of impulse noise exposure could cause NIHHL in guinea pigs and 200 times could cause completely hearing loss. Impulse noise exposure could cause a dramatic increase in chondriosome in the inner hair cell. The structures of ribbon synapses and heminodes were also obviously impaired compared to the normal group. The nerve fibers and myelin sheaths remained intact after impulse noise exposure. Conclusion: This research revealed for the first time that impulse noise could cause hidden hearing loss, and the changes in inner hair cells, ribbon synapse, and heminode all played a vital role in the pathogenesis of hidden hearing loss.
Impact of Testosterone Therapy on hypogonadal patients unresponsive to phosphodiesterase-5 inhibitors alone: A systematic review and a meta-analysis
Authors: Yu Xiaowei , Liu Yanhong , Zhang Xiaoyuan , Wang Qun 
Published: October 2021

Abstract
Background

Phosphodiesterase-5 inhibitors as the first-line treatment for erectile dysfunction, when patients with hypogonadism fail to respond to phosphodiesterase-5 inhibitors, the beneficial of addition testosterone therapy is a major concern for clinicians. The objective of this study was to collect and summarize the evidence that evaluated the benefit of addition testosterone therapy in hypogonadism fail to respond to phosphodiesterase-5 inhibitors.
Methods

Electronic literature searches of Cochrane Library, PubMed, MEDLINE and EMBASE databases were conducted up to October 2020 and included randomized controlled trials. Specifically, we were looking for papers where Erectile Function Domain Score differences between pre and post-treatment were used as the primary outcome after treatment of testosterone therapy alone, phosphodiesterase-5 inhibitors therapy alone, or a dual treatment of both testosterone therapy and phosphodiesterase-5 inhibitors. Secondary outcomes included the number of phosphodiesterase-5 inhibitors non-responders who subsequently reported a satisfactory treatment of dual treatment with testosterone therapy and phosphodiesterase-5 inhibitors.
Results

A total of 4 studies that met our criteria, consisting of 326 patients. The Erectile Function Domain Score was significantly higher after treatment of testosterone combine with phosphodiesterase-5 inhibitors(4.88[4.18–5.57]), phosphodiesterase-5 inhibitors with placebo(3.15[1.82–4.47]), and testosterone monotherapy (2.04[0.38–3.71]) compared with baseline. Dual treatment with testosterone and phosphodiesterase-5 inhibitors significantly improved Erectile Function Domain Score when compared with testosterone monotherapy (3.16, 95% CI: 1.79–4.53), Of 41.7% patients in the dual treatment group reported an improvement, compared to only 33.0% in phosphodiesterase-5 inhibitors treatment group.
Conclusions

Combination therapy of testosterone and phosphodiesterase-5 inhibitors seems most effective in men with both erectile dysfunction and hypogonadism who initial unrespond to phosphodiesterase-5 inhibitors.
Debt strategies of European countries and vectors of implementation of best experience in the practice of external public debt management of Ukraine
Authors: Moroz Ivanna 
Published: October 2021

The policy of external and domestic public debt management in different countries has its own specifics, and its results are not always unambiguous. Thus, the existing recommendations of the International Monetary Fund and the Maastricht criteria prove that the maximum value of public debt to GDP should be no more than 60 %. Exceeding this limit can lead to a deterioration in financial stability, debt sustainability, and ultimately to a technical default of the state. However, the practice of public debt management in many developed countries shows quite opposite trends, as a significant excess of the Maastricht criterion not only does not lead to default, but on the contrary allows countries to accumulate the necessary financial resources to ensure stable economic growth.
Therefore, the study of European debt strategies and their effectiveness is a very important issue, especially given the consequences of the COVID-19 pandemic for developing countries. Given the growing external debt dependence of Ukraine as a result of both the war with the Russian Federation and the COVID-19 pandemic, the search for a better experience of European debt policy and consideration of ways to adapt it to domestic realities are discussed in our article.
Based on the analysis of the debt policy of European countries, the expediency of using debt rules, aimed at regulating both the country's debt security and the effectiveness of the use of public borrowing to stimulate economic growth has been proved.
Cluster analysis of debt strategies of some European countries has shown that the high level of dependence on external public debt has a negative impact on economic security in general, because in the event of deteriorating macroeconomic situation, the likelihood of foreign investors selling government securities increases, and in the case of external loans from international financial and credit organizations – the risks of negative impact of burdensome non-financial obligations on the national economy grow.
Determination of the informational content of symptoms in the dynamic processes of assessing the patient’s condition in e-health
Authors: Shevchenko Yaroslav 
Published: October 2021

The study is devoted to substantiating the tactics of choosing the signs of the patient's condition for diagnostic decision-making on corrective medical intervention in mobile medicine.
The aim of the research: to study a creation of a methodology for determining the integral informativeness of the patient's symptoms during remote monitoring of his condition.
Materials and methods: this article is based on search results in PubMed, Scopus, MEDLINE, EMBASE, PsycINFO, Global Health, Web of Science, Cochrane Library, UK NHS HTA articles published between January 1991 and January 2021 and containing the search terms “information technology”, “Mobile medicine”, “digital pathology” and “deep learning”, as well as the results of the authors' own research. The authors independently extracted data on concealment of distribution, consistency of distribution, blindness, completeness of follow-up, and interventions.
Results: concluded that to determine the Informativeness of symptoms in mobile monitoring of patients, it is possible to use risk indicators of predicted conditions as a universal method. Given that the Informativeness of the patient's condition changes constantly, for online diagnosis of conditions during remote monitoring of the patient it is recommended to use the function of informative symptoms from time to time and use a set of approaches to assess the Informativeness of patient symptoms. It is proposed to use the strategy of diagnosis and treatment using probabilistic algorithms based on the values of the risk of complications of the pathological process, as well as the formulas of Kulbach and Shannon to determine individual trends in the pathological patient process.
Conclusion: there was proposed to use risk indicators of predicted conditions as a universal method for determining the informational content of symptoms in mobile monitoring of patients.
Biological nitrogen in increasing the productivity of beans (grains)
Authors: Chynchyk Oleksandr , Olifirovych Svitlana , Olifirovych Volodymyr , Nebaba Kateryna 
Published: October 2021

The results of a field experiment to study the effect of seed treatment with the biological product Rhizoactive (сompany BioNorma, Ukraine) on the formation and functioning of the symbiotic apparatus of common bean (grain) plants are presented.
The experiment examined six varieties of common beans (grain), included in the State Register of plant varieties suitable for distribution in Ukraine: Bukovynka, Halaktyka, Slaviia, Ros, Otrada, Nata. The influence of bacterial fertilizer based on nodule bacteria " Rhizoactive " on the indicators of symbiotic and grain productivity of these varieties of common beans was studied.
It was found, that the maximum number and raw weight of active nodules in the studied varieties of common beans were formed in the flowering phase. A larger number of nodules, compared to the variety Bukovynka (control), was formed on the root system of bean varieties Ros, Otrada and Nata. The maximum raw weight of rhizobia in the plots without the use of Rhizoactive was formed by the common bean variety Otrada – 0.297 g/plant of active nodules. Inoculation of the seeds of the studied common bean varieties with Rhizoactive increased the raw weight of active nodules in the flowering phase by 0.016–0.042 g/plant. A larger mass of nodules, compared to the Bukovynka variety, was formed on the root system of Ros, Otrada and Nata beans. The maximum raw weight of rhizobia in areas without the use of Rhizoactive was formed by the variety of beans Otrada – 0.297 g/plant of active nodules. Inoculation of seeds of the studied varieties of beans with Rhizoactive increased the raw weight of active nodules in the flowering phase by 0.016–0.042 g/plant.
The highest increase in grain yield from seed inoculation was obtained in 2018, which was more favorable in terms of moisture. Thus, the largest increase in grain yield from the use of Rhizoactive was provided by the varieties Halaktyka (0.14 t/ha or 5.7 %), Ros (0.15 t/ha or 5.5 %) and Otrada (0.22 t/ha or 7.7 %). On average, in 2018–2020, inoculation of bean seeds with Rhizoactive, depending on the variety, provided an increase in grain yield from 2.4 to 6.7 %. And the highest level of bean grain yield on average in 2018–2020 was provided by the varieties Otrada (2.60 t/ha), Nata (2.50 t/ha) and Ros (2.40 t/ha) for inoculation of seeds with Rhizoactive
Prospects for the use of apiproducts in human healthy nutrition
Authors: Prytulska Natalia , Karpenko Petro , Antiushko Dmytro , Bozhko Tetiiana , Shapovalova Nataliia 
Published: October 2021

It has been established, that the development and implementation of the practice of using biologically active components of nutrition is one of the areas of modern dietetics, which are developing dynamically. Apiproducts are a very promising source of biologically active substances. Fundamental studies of domestic and foreign scientists have proven their high biological value, versatile pharmacological activity (anti-inflammatory, antimicrobial, analgesic, antioxidant, immunostimulatory, anti-radiation, etc.). The use of apiproducts for the prevention and treatment of a number of human diseases is a comprehensively studied phenomenon in terms of beekeeping, botany, chemistry, microbiology, pharmacology, medicine and pharmacy.
It has been proved, that the action of individual apiproducts and their components allows to use them effectively in practical apitherapy. Because these products differ significantly depending on their chemical composition, they are divided into two groups. The first includes honey, flower pollen, perga (a product of conservation of flower pollen in a hive) and, in part, drone brood. As mixtures of valuable BAS and metabolites, they are used mainly to increase the biological value of traditional foods and create new compositions. The second group includes bee venom, propolis and, in part, royal jelly, which are therapeutic agents by their nature and are used to correct physiological functions and metabolism, have regulatory effects, and their action is realized through the effect on the lipid matrix of biological membranes and membrane proteins. It has been established, that the use of these food components in health nutrition and production of health and medical foods is a promising area
Graphenoxide Cross-Linker Based Potentiometric Biosensor Design for Sarcosine Determination
Authors: Ünlüer Özlem Biçen , Altunkök Nazire , Özkütük Ebru Birlik , Ersöz Arzu 
Published: October 2021

Background:Sarcosine, also known as N-methyl glycine, is a natural amino acid that is an intermediate and by product in glycine synthesis and degradation. Recently found in many peptides, sarcosine has been researched as a newly accepted prostate cancer marker. The increased concentration of sarcosine in blood serum and the urine showed that malignancy of measured prostate cancer cells is active.Objective:In this article, we aimed to design a potentiometric biosensor for detection of sarcosine with a low detection limit, high selectivity, short response time, wide linear range, and satisfactory long-term stability.Methods:In this article, we developed a new Graphene oxide (GFOX) photosensitive cross-linker based potentiometric biosensor based on the AmiNoAcid (monomer) Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method. The functional groups determined using Raman, FT-IR, XPS analyzes, and surface characterization, the morphology of synthesized GFOX photosensitive cross-linker were determined by TEM and AFM studies. Then, the performance of the GFOX based potentiometric biosensor has been evaluated.Results:When the usage of the developed GFOX doped potentiometric biosensor against sarcosine determination, it was found that 10-4mM sarcosine was determined in 60 seconds in the solution. In addition, the detection limit of the GFOX doped potentiometric biosensor was found to be 9.45x10-7mM, and the linear potentiometric biosensor was found to be in the concentration range of 10-1to 10-5mM. The selectivity studies of the developed potentiometric biosensor were investigated using glycine solutions, and it was determined that GFOX doped potentiometric biosensor was more selective against sarcosine. Besides this, a reusability test using 10-3 mM sarcosine solution showed that reproducible studies were performed without the loss of potential of designed potentiometric biosensor and no loss of sensitivity.Conclusion:After applying the framework, we get a new potentiometric biosensor for sarcosine determination. GFOX photosensitive cross-linker was used in designing potentiometric biosensors, and this increased the stability and efficiency of the biosensor. Therefore, the developed potentiometric biosensor for sarcosine determination could be easily used for the early diagnosis of prostate cancer.