bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and safety of a new endoscopic synthetic sealant nebulizing device over gastric endoscopic submucosal dissections
Authors: Boškoski Ivo , Hamanaka Jun , Barbaro Federico , Arena Vincenzo , Mascagni Pietro , Caristo Maria Emiliana , De Siena Martina , Gallo Camilla , Costamagna Guido 
Published: April 2021

Abstract
Background
Endoscopic Submucosal Dissection (ESD) is the treatment of choice of superficial neoplastic gastrointestinal lesions. Delayed bleedings and perforations are still current clinical concerns. Glubran 2 is a synthetic cyanoacrylate-derived glue nowadays already widely used as an effective tissue adhesive. ENDONEB is a novel device thought for enabling the sealant nebulization over a specific targeted surface during laparotomy, laparoscopy, and thoracotomy. The aim of this single-center preclinical animal trial is to evaluate the feasibility and safety of the same nebulization technique during ESD in the perspective that further clinical studies would demonstrate the efficacy of Glubran 2 in preventing post-ESD adverse events.

Methods
Four live Landrace pigs were enrolled. Two approximately 30-mm-wide gastric ESDs were performed in each pig (experimental ESD and control ESD). About 0.5 mL of Glubran 2 was nebulized on the experimental ESDs. Subjective perception of the feasibility of the Glubran 2 nebulization was reported. Pigs were clinically monitored at follow-up and upper GI endoscopy was performed at 24 and 48 hours, when animals were euthanized to perform a macroscopic and histological analysis of the specimens.

Results
No peri-procedural adverse events were reported. Glubran 2 nebulization over experimental ESDs showed to be technically easy and time-effective. Clinical and endoscopic animal monitoring was negative at follow-up. At 24 hours, the Glubran 2 film was clearly visible on the eschar of the ESDs and signs of initial hydrolysis were discernable at 48 hours. No signs of peritoneal reaction were observed at the macroscopic examination. Equal transmural inflammation was described at the histological examination of both types of ESDs.

Conclusions
Safety and feasibility profiles of Glubran 2 nebulizing ENDONEB device over ESD surfaces were excellent. Further evidences and human trials are needed to investigate its effectiveness in ESDs’ eschars sealing and, thus, in delayed micro-perforations and bleedings prevention and treatment.
Identifying classes of the pain, fatigue, and depression symptom cluster in long-term prostate cancer survivors—results from the multi-regional Prostate Cancer Survivorship Study in Switzerland (PROCAS)
Authors: Adam Salome , Thong Melissa S. Y. , Martin-Diener Eva , Camey Bertrand , Egger Hayoz Céline , Konzelmann Isabelle , Mousavi Seyed Mohsen , Herrmann Christian , Rohrmann Sabine , Wanner Miriam , Staehelin Katharina , Strebel Räto T. , Randazzo Marco , John Hubert , Schmid Hans-Peter , Feller Anita , Arndt Volker 
Published: April 2021

Abstract
Purpose
Aside from urological and sexual problems, long-term (≥5 years after initial diagnosis) prostate cancer (PC) survivors might suffer from pain, fatigue, and depression. These concurrent symptoms can form a cluster. In this study, we aimed to investigate classes of this symptom cluster in long-term PC survivors, to classify PC survivors accordingly, and to explore associations between classes of this cluster and health-related quality of life (HRQoL).

Methods
Six hundred fifty-three stage T1-T3N0M0 survivors were identified from the Prostate Cancer Survivorship in Switzerland (PROCAS) study. Fatigue was assessed with the EORTC QLQ-FA12, depressive symptoms with the MHI-5, and pain with the EORTC QLQ-C30 questionnaire. Latent class analysis was used to derive cluster classes. Factors associated with the derived classes were determined using multinomial logistic regression analysis.

Results
Three classes were identified: class 1 (61.4%) – “low pain, low physical and emotional fatigue, moderate depressive symptoms”; class 2 (15.1%) – “low physical fatigue and pain, moderate emotional fatigue, high depressive symptoms”; class 3 (23.5%) – high scores for all symptoms. Survivors in classes 2 and 3 were more likely to be physically inactive, report a history of depression or some other specific comorbidity, be treated with radiation therapy, and have worse HRQoL outcomes compared to class 1.

Conclusion
Three distinct classes of the pain, fatigue, and depression cluster were identified, which are associated with treatment, comorbidities, lifestyle factors, and HRQoL outcomes. Improving classification of PC survivors according to severity of multiple symptoms could assist in developing interventions tailored to survivors’ needs.
Anti-mitochondrial autoantibodies are associated with cardiomyopathy, dysphagia, and features of more severe disease in adult-onset myositis
Authors: Sabbagh Sara E. , Pinal-Fernandez Iago , Casal-Dominguez Maria , Albayda Jemima , Paik Julie J. , Miller Frederick W. , Rider Lisa G. , Mammen Andrew L. , Christopher-Stine Lisa ,   for the Johns Hopkins Myositis Center Group, Michelle Harlan , Tiniakou Eleni , Danoff Sonye K. , Lloyd Tom 
Published: April 2021

AbstractWe analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences in myositis patients with AMA. We screened sera from myositis patients including 619 adult- and 371 juvenile-onset dermatomyositis (DM, JDM), polymyositis (PM, JPM), inclusion body myositis (IBM), or amyopathic DM patients and from healthy controls, including 164 adults and 92 children, for AMA by ELISA. Clinical characteristics were compared between myositis patients with and without AMA. AMA were present in 5% of adult myositis patients (16 of 216 DM, 10 of 222 PM, 4 of 140 IBM, 1 of 19 amyopathic DM), 1% of juvenile myositis patients (3 of 302 JDM, 1 of 25 JPM), and 1% of both adult and juvenile healthy controls. In patients with adult-onset myositis, AMA were associated with persistent muscle weakness, Raynaud’s phenomenon, dysphagia, and cardiomyopathy. Adult myositis patients with AMA may have more severe or treatment refractory disease, as they more frequently received glucocorticoids and intravenous immunoglobulin. In juvenile myositis, children with AMA often had falling episodes and dysphagia, but no other clinical features or medications were significantly associated with AMA. AMA are present in 5% of adult myositis patients and associated with cardiomyopathy, dysphagia, and other signs of severe disease. The prevalence of AMA is not increased in patients with juvenile myositis compared to age-matched healthy controls. Our data suggest that the presence of AMA in adult myositis patients should prompt screening for cardiac and swallowing involvement.

Key Points• Approximately 5% of a large North American cohort of adult myositis patients have anti-mitochondrial autoantibodies.• Adults with anti-mitochondrial autoantibodies often have chronic weakness, Raynaud’s, dysphagia, cardiomyopathy, and more severe disease.• Anti-mitochondrial autoantibodies are rare in juvenile myositis and not associated with a specific clinical phenotype.
New insight into the stability and dynamics of fluid-conveying supported pipes with small geometric imperfections
Authors: Zhou Kun , Ni Qiao , Chen Wei , Dai Huliang , Peng Zerui , Wang Lin 
Published: April 2021

AbstractIn several previous studies, it was reported that a supported pipe with small geometric imperfections would lose stability when the internal flow velocity became sufficiently high. Recently, however, it has become clear that this conclusion may be at best incomplete. A reevaluation of the problem is undertaken here by essentially considering the flow-induced static deformation of a pipe. With the aid of the absolute nodal coordinate formulation (ANCF) and the extended Lagrange equations for dynamical systems containing non-material volumes, the nonlinear governing equations of a pipe with three different geometric imperfections are introduced and formulated. Based on extensive numerical calculations, the static equilibrium configuration, the stability, and the nonlinear dynamics of the considered pipe system are determined and analyzed. The results show that for a supported pipe with the geometric imperfection of a half sinusoidal wave, the dynamical system could not lose stability even if the flow velocity reaches an extremely high value of 40. However, for a supported pipe with the geometric imperfection of one or one and a half sinusoidal waves, the first-mode buckling instability would take place at high flow velocity. Moreover, based on a further parametric analysis, the effects of the amplitude of the geometric imperfection and the aspect ratio of the pipe on the static deformation, the critical flow velocity for buckling instability, and the nonlinear responses of the supported pipes with geometric imperfections are analyzed.
Thermal Stability of Ru–Re NPs in H2 and O2 Atmosphere and Their Activity in VOCs Oxidation: Effect of Ru Precursor
Authors: Okal Janina , Adamska Katarzyna 
Published: April 2021

AbstractThe thermal stability of Ru–Re NPs on γ-alumina support was studied in hydrogen at 800 °C and in air at 250–400 °C. The catalysts were synthesized using Cl-free and Cl-containing Ru precursors and NH4ReO4. Very high sintering resistance of Ru–Re NPs was found in hydrogen atmosphere and independent of Ru precursors and Re loading, the size of them was below 2–3 nm. In air, metal segregation occurred at 250 °C, leading to formation of RuO2 and highly dispersed ReOx species. Ruthenium agglomeration was hindered at higher Re loading and in presence of residual Cl species. Propane oxidation rate was higher with the Ru(N)–Re catalysts than with Ru(N) and that containing Cl species. The Ru(N)–Re (3:1) catalyst exhibited the highest activity and the lowest activation energy (91.6 kJ mol−1) what is in contrast to Ru(Cl)–Re (3:1) which had the lowest activity and the highest activation energy (119.3 kJ mol−1). Thus, the synergy effect was not observed in Cl-containing catalysts.
Graphic Abstract
Low-cost Position and Force Measurement System for Payload Transport Using UAVs
Authors: Gandolfo Daniel Ceferino , Rosales Claudio D. , Salinas Lucio R. , Gimenez J. , Carelli Ricardo 
Published: April 2021

AbstractIn recent years, multiple applications have emerged in the area of payload transport using unmanned aerial vehicles (UAVs). This has attracted considerable interest among the scientific community, especially the cases involving one or several rotary-wing UAVs. In this context, this work proposes a novel measurement system which can estimate the payload position and the force exerted by it on the UAV. This measurement system is low cost, easy to implement, and can be used either in indoor or outdoor environments (no sensorized laboratory is needed). The measurement system is validated statically and dynamically. In the first test, the estimations obtained by the system are compared with measurements produced by high-precision devices. In the second test, the system is used in real experiments to compare its performance with the ones obtained using known procedures. These experiments allowed to draw interesting conclusions on which future research can be based.
Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice
Authors: Zhao Shiyi , Li Rui , Li Huiming , Wang Sa , Zhang Xinxin , Wang Dan , Guo Juan , Li Huihui , Li Ao , Tong Tingting , Zhong Haixing , Yang Qianzi , Dong Hailong 
Published: April 2021

AbstractThe lateral hypothalamic area (LHA) plays a pivotal role in regulating consciousness transition, in which orexinergic neurons, GABAergic neurons, and melanin-concentrating hormone neurons are involved. Glutamatergic neurons have a large population in the LHA, but their anesthesia-related effect has not been explored. Here, we found that genetic ablation of LHA glutamatergic neurons shortened the induction time and prolonged the recovery time of isoflurane anesthesia in mice. In contrast, chemogenetic activation of LHA glutamatergic neurons increased the time to anesthesia and decreased the time to recovery. Optogenetic activation of LHA glutamatergic neurons during the maintenance of anesthesia reduced the burst suppression pattern of the electroencephalogram (EEG) and shifted EEG features to an arousal pattern. Photostimulation of LHA glutamatergic projections to the lateral habenula (LHb) also facilitated the emergence from anesthesia and the transition of anesthesia depth to a lighter level. Collectively, LHA glutamatergic neurons and their projections to the LHb regulate anesthetic potency and EEG features.
Tropical agroindustrial biowaste revalorization through integrative biorefineries—review part I: coffee and palm oil by-products
Authors: Mora-Villalobos Jose-Aníbal , Aguilar Francisco , Carballo-Arce Ana-Francis , Vega-Baudrit José-Roberto , Trimino-Vazquez Humberto , Villegas-Peñaranda Luis Roberto , Stöbener Anne , Eixenberger Daniela , Bubenheim Paul , Sandoval-Barrantes Manuel , Liese Andreas 
Published: April 2021

AbstractTropical crops are an important source of wealth in many countries. The current agribusiness model is based on the production of a final commodity, leading to the production of organic by-products (biowastes) that in many cases contain bioactive compounds with a potential added value. The exploitation of these by-products is the foundation of the circular economy that leads to the generation of greener bioprocesses for the industry with foreseeable economic improvements in production systems. This review aims to point out the idle opportunities of agricultural production systems and their associated biowastes to contribute to the establishment of a bioeconomy. Hence, the focus lies on five tropical extensive crops: coffee, oil palm, sugar cane, banana, and pineapple. This first part of the review explores agricultural wastes originated from the coffee and oil palm industrial process and is oriented on the potential use of these by-products as a starting material for the alternative obtention of chemicals, otherwise obtained from petrochemistry. The second part of the review focuses on prospective use of lignocellulosic rich biowaste that is derived from the industrialization of sugar cane, banana, and pineapple. A fundamental difference for the use of coffee biomass compared to other crops is the presence of numerous bioactive compounds that are not yet properly utilized, such as antioxidants (i.e., caffeic acid, chlorogenic acid, ferulic acid), as well as their possible use in the manufacture of products of interest in the cosmetic (i.e., quinic acid) or pharmaceutical industry (i.e., caffeic acid phenethyl ester). In the case of oil palm, its potential lies in obtaining chemicals such as glycerol and carotenoids, or in the bioenergy production.
Breaking Through Bottlenecks for Thermally Conductive Polymer Composites: A Perspective for Intrinsic Thermal Conductivity, Interfacial Thermal Resistance and Theoretics
Authors: Gu Junwei , Ruan Kunpeng 
Published: April 2021

AbstractRapid development of energy, electrical and electronic technologies has put forward higher requirements for the thermal conductivities of polymers and their composites. However, the thermal conductivity coefficient (λ) values of prepared thermally conductive polymer composites are still difficult to achieve expectations, which has become the bottleneck in the fields of thermally conductive polymer composites. Aimed at that, based on the accumulation of the previous research works by related researchers and our research group, this paper proposes three possible directions for breaking through the bottlenecks: (1) preparing and synthesizing intrinsically thermally conductive polymers, (2) reducing the interfacial thermal resistance in thermally conductive polymer composites, and (3) establishing suitable thermal conduction models and studying inner thermal conduction mechanism to guide experimental optimization. Also, the future development trends of the three above-mentioned directions are foreseen, hoping to provide certain basis and guidance for the preparation, researches and development of thermally conductive polymers and their composites.
Effects of memristive synapse radiation interactions on learning in spiking neural networks
Authors: Gandharava Dahl Sumedha , Ivans Robert C. , Cantley Kurtis D. 
Published: April 2021

AbstractThis study uses advanced modeling and simulation to explore the effects of external events such as radiation interactions on the synaptic devices in an electronic spiking neural network. Specifically, the networks are trained using the spike-timing-dependent plasticity (STDP) learning rule to recognize spatio-temporal patterns (STPs) representing 25 and 100-pixel characters. Memristive synapses based on a TiO2 non-linear drift model designed in Verilog-A are utilized, with STDP learning behavior achieved through bi-phasic pre- and post-synaptic action potentials. The models are modified to include experimentally observed state-altering and ionizing radiation effects on the device. It is found that radiation interactions tend to make the connection between afferents stronger by increasing the conductance of synapses overall, subsequently distorting the STDP learning curve. In the absence of consistent STPs, these effects accumulate over time and make the synaptic weight evolutions unstable. With STPs at lower flux intensities, the network can recover and relearn with constant training. However, higher flux can overwhelm the leaky integrate-and-fire post-synaptic neuron circuits and reduce stability of the network.
Self-passivating smart tungsten alloys for DEMO: a progress in joining and upscale for a first wall mockup
Authors: Bachurina Diana , Tan Xiao-Yue , Klein Felix , Suchkov Alexey , Litnovsky Andrey , Schmitz Janina , Gonzalez-Julian Jesus , Bram Martin , Coenen Jan Willem , Wu Yu-Cheng , Linsmeier Christian 
Published: April 2021

AbstractSelf-passivating, so-called smart alloys are under development for a future fusion power plant. These alloys containing tungsten, chromium and yttrium must possess an acceptable plasma performance during a regular plasma operation of a power plant and demonstrate the suppression of non-desirable oxidation of tungsten in case of an accident. The up-scaling of the bulk smart alloys to the reactor-relevant sizes has begun and the first samples with a diameter of 50 mm and thickness of 5 mm became available. The samples feature high relative density of above 99% and good homogeneity. With production of bulk samples, the research program on joining the smart alloy to the structural material was initiated. In a present study, the novel titanium–zirconium–beryllium braze was applied successfully to join the smart alloy to the Rusfer-reduced-activation steel. The braze has survived at least a hundred of cyclic thermal excursions in the range of 300–600 °C without mechanical destruction.
Biblical Philosophy
Authors: Johnson Dru 
Published: April 2021

In Biblical Philosophy, Dru Johnson examines how the texts of Christian Scripture argue philosophically with ancient and modern readers alike. He demonstrates how biblical literature bears the distinct markers of a philosophical style in its use of literary and philosophical strategies to reason about the nature of reality and our place within it. Johnson questions traditional definitions of philosophy and compares the Hebraic style of philosophy with the intellectual projects of ancient Egypt, Mesopotamia, and Hellenism. Identifying the genetic features of the Hebraic philosophical style, Johnson traces its development from its hybridization in Hellenistic Judaism to its retrieval by the New Testament authors. He also shows how the Gospels and letters of Paul exhibit the same genetic markers, modes of argument, particular argument forms, and philosophical convictions that define the Hebraic style, while they engaged with Hellenistic rhetoric. His volume offers a model for thinking about philosophical styles in comparative philosophical discussions.
Use of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in A Tertiary Care Memory Clinic
Authors: Stiffel Michael , Bergeron David , Mourabit Amari Karim , Poulin Élizabeth , Roberge Xavier , Meilleur-Durand Synthia , Sellami Leila , Molin Pierre , Nadeau Yannick , Fortin Marie-Pierre , Caron Stéphanie , Poulin Stéphane , Verret Louis , Bouchard Rémi W. , Teunissen Charlotte , Laforce Robert Jr 
Published: April 2021

ABSTRACT:Introduction:Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers are promising tools to help identify the underlying pathology of neurocognitive disorders. In this manuscript, we report our experience with AD CSF biomarkers in 262 consecutive patients in a tertiary care memory clinic.Methods:We retrospectively reviewed 262 consecutive patients who underwent lumbar puncture (LP) and CSF measurement of AD biomarkers (Aβ1–42, total tau or t-tau, and p-tau181). We studied the safety of the procedure and its impact on patient’s diagnosis and management.Results:The LP allowed to identify underlying AD pathology in 72 of the 121 patients (59%) with early onset amnestic mild cognitive impairment (aMCI) with a high probability of progression to AD; to distinguish the behavioral/dysexecutive variant of AD from the behavioral variant of frontotemporal dementia (bvFTD) in 25 of the 45 patients (55%) with an atypical neurobehavioral profile; to identify AD as the underlying pathology in 15 of the 27 patients (55%) with atypical or unclassifiable primary progressive aphasia (PPA); and to distinguish AD from other disorders in 9 of the 29 patients (31%) with psychiatric differential diagnoses and 19 of the 40 patients (47%) with lesional differential diagnoses (normal pressure hydrocephalus, encephalitis, prion disease, etc.). No major complications occurred following the LP.Interpretation:Our results suggest that CSF analysis is a safe and effective diagnostic tool in select patients with neurocognitive disorders. We advocate for a wider use of this biomarker in tertiary care memory clinics in Canada.
Seasonal dynamics of snow ablation on selected glaciers in central Spitsbergen derived from Sentinel-2 satellite images
Authors: Kavan Jan , Haagmans Vincent 
Published: April 2021

AbstractThe dynamics of seasonal snow ablation on six glaciers in central Spitsbergen (Dicksonland) were assessed by examining a set of Sentinel-2 satellite images covering the summer ablation season for the period 2016–19. All glaciers lost 80% or more of their surface snow cover during the studied ablation seasons. This bolsters the recently observed trend of local glacier thinning, even at higher altitudes. Snow ablation dynamics are highly dependent on the glaciers altitudes, their position relative to the prevailing wind direction and the exposure to insolation. The accumulation areas of the studied glaciers were delimited based on the overlap of the minimum extent of snow-covered areas in the four consecutive studied summer seasons. The high temporal and spatial resolutions of available images enabled a detailed description of the seasonal snow ablation dynamics. Moreover, an estimate of the average number of days with below threshold glacier snow cover was made. This study contributes to our understanding of recent processes and might further support the modelling of glacier melt and subsequent runoff.