bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial culture and immunohistochemical detection of bacteria and endotoxin in cats with suppurative cholangitis-cholangiohepatitis syndrome
Authors: Center Sharon A. , Randolph John F. , Warner Karen L. , McDonough Sean P. , Lucy John M. , Sapa Kirk C. 
Published: December 2021

Abstract

OBJECTIVE
To characterize the frequency and type of bacterial infection by culture- and immunohistochemical (IHC)-based methods and determine the impact of infection on clinical features and survival time in cats with suppurative cholangitis-cholangiohepatitis syndrome (S-CCHS).

ANIMALS
168 client-owned cats with S-CCHS (cases).

PROCEDURES
Clinical features, bacterial culture results, culture-inoculate sources, and survival details were recorded. Cases were subcategorized by comorbidity (extrahepatic bile duct obstruction, cholelithiasis, cholecystitis, ductal plate malformation, biopsy-confirmed inflammatory bowel disease, and biopsy-confirmed pancreatitis) or treatment by cholecystectomy or cholecystoenterostomy. Culture results, bacterial isolates, Gram-stain characteristics, and IHC staining were compared among comorbidities. Lipoteichoic acid IHC staining detected gram-positive bacterial cell wall components, and toll-like receptor expression IHC reflected pathologic endotoxin (gram-negative bacteria) exposure.

RESULTS
Clinical features were similar among cases except for more frequent abdominal pain and lethargy in cats with positive culture results and pyrexia, abdominal pain, and hepatomegaly for cats with polymicrobial infections. Bacteria were cultured in 93 of 135 (69%) cats, with common isolates including Enterococcus spp and Escherichia coli. IHC staining was positive in 142 of 151 (94%) cats (lipoteichoic acid, 107/142 [75%]; toll-like receptor 4, 99/142 [70%]). With in-parallel interpretation of culture and IHC-based bacterial detection, 154 of 166 (93%) cats had bacterial infections (gram-positive, 118/154 [77%]; gram-negative, 111/154 [72%]; polymicrobial, 79/154 [51%]). Greater frequency of bacterial isolation occurred with combined tissue, bile, and crushed cholelith inoculates. Infection and gram-positive bacterial isolates were associated with significantly shorter long-term survival times.

CLINICAL RELEVANCE
S-CCHS was associated with bacterial infection, pathologic endotoxin exposure, and frequent polymicrobial infection in cats. Combined tissue inoculates improved culture detection of associated bacteria.
Clinical features, concurrent disorders, and survival time in cats with suppurative cholangitis-cholangiohepatitis syndrome
Authors: Center Sharon A. , Randolph John F. , Warner Karen L. , Flanders James A. , Harvey H. Jay 
Published: December 2021

Abstract

OBJECTIVE
To characterize clinical features, comorbidities, frequency of bacterial isolation, and survival time in cats with suppurative cholangitis-cholangiohepatitis syndrome (S-CCHS).

ANIMALS
168 client-owned cats with S-CCHS.

PROCEDURES
Data were prospectively (1980 to 2019) collected regarding clinical features, comorbidities, bacterial infection, illness duration, and treatments. Variables were evaluated for associations with survival time.

RESULTS
Median age of cats was 10.0 years, with no breed or sex predilection observed. Common clinical features included hyporexia (82%), hyperbilirubinemia (80%), lethargy (80%), vomiting (80%), jaundice (67%), weight loss (54%), and hypoalbuminemia (50%). Comorbidities included extrahepatic bile duct obstruction (53%), cholelithiasis (42%), cholecystitis (40%), and ductal plate malformation (44%) as well as biopsy-confirmed inflammatory bowel disease (60/68 [88%]) and pancreatitis (41/44 [93%]). Bacterial cultures were commonly positive (69%) despite prebiopsy antimicrobial administration in most cats. Of surgically confirmed choleliths, diagnostic imaging identified only 58%. Among 55 cats with “idiopathic pancreatitis,” 28 (51%) were documented to have transiting choleliths, and 20 had pancreatic biopsies confirming pancreatitis. Cholelithiasis (with or without bile duct obstruction) and cholecystectomy were associated with survival advantages. Survival disadvantages were found for leukocytosis, ≥ 2-fold increased alkaline phosphatase, and hyperbilirubinemia. Cholecystoenterostomy had no survival impact. Cats with ductal plate malformations were significantly younger at diagnosis and death than other cats. Chronic treatments with antimicrobials, S-adenosylmethionine, and ursodeoxycholic acid were common postbiopsy.

CLINICAL RELEVANCE
S-CCHS in cats was associated with bacterial infection and various comorbidities and may be confused with pancreatitis. Surgically correctable morbidities (ie, cholecystitis, cholecystocholelithiasis) and cholecystectomy provided a significant survival advantage.
Challenges in sustaining resilience in the coastal settlements of south-eastern Bangladesh: Achieving self-sustenance through architectural synthesis
Authors: Sohaana Anika Imraana , Rahman Md Arifur 
Published: December 2021

Abstract
The coastal settlements in Bangladesh experienced recurring tropical cyclones and tidal surges in recent history because of geographical influences and global climate change. Despite improved evacuation management and adequate cyclone shelters patronized by donors, lately resulting in a reduced mortality rate, the property and economic losses were still substantial due to vulnerability of the settlements. As the short-term adaptative approaches such as migrating to the closest cyclone shelters have failed to sustain resilience, comprehensive and inclusive mitigation planning should be implemented to achieve more resilience in the long term. The research aimed to revise the conventional culturally-void concept and propose a prolonged solution by planning a self-sustained model of the cyclone-resilient village for the south-western coastal communities of Bangladesh. Initially, it searched for the identification and analysis of socio-cultural, economic, and environmental challenges in sustaining community resilience and later synthesizing architectural interventions to achieve self-sustenance. The synthesis focused on reducing the vulnerability of the coastal communities by enhancing their preparedness, resistance, and recovery from the prolonged impacts of coastal disasters through designing structurally and environmentally resilient homesteads, defensive landscape plans, and socioeconomic-communal development. The ultimate proposal offers more flexibility in selecting homesteads according to suitable materials, affordability, and profession.
Restorations in post-war period
Authors: Jelínková Martina 
Published: December 2021

Abstract
The choice of the monument care methodology depends not only on the preference of the author of the restoration or the opinion of a professional monument commission, but also on the state in which the historic building is and historical stages it developed through. After the Second World War, much of the architectural historical heritage in the territory of the former Czechoslovakia was devastated, and the then professional society faced challenges of how to restore and preserve these destroyed buildings. The following article explains the starting points and selected methods of post-war monument care on the example of three churches in the former Czechoslovakia. Buildings selected for comparison originated in approximately the same epoch, underwent a rather complex building developments, and the extent of their damage was also similar. Specifically, we focus on the Church of St. Catherine of Alexandria in Handlová, the Church of the Assumption of the Virgin Mary in Bíňa and the Church of the Virgin Mary and the Holy Slavic Patrons in Prague. Although the three compared cases show similarities, different restoration methodologies were used. The majority opinion of the then professional public tended towards reconstructing historic buildings to the state before their destruction, as is also evident in the cases being compared. Nevertheless, each of the churches is restored with some deviations from the original condition. In the case of the church in Bíňa, we follow traces of a purist reconstruction, in Prague we witness a restoration by indicative reconstruction, also applied in Handlová, where, moreover, the methodology of reconstruction to the state before destruction was completely abandoned. Our ambition is to point out the diversity of opinion in the care of monuments, which at that time saw a change in paradigm and began to accept authors’ new inputs while preserving the historical essence of the building.
Histopathological comparison of the salivary glands’ acini and striated ducts after experimental prolonged daily administration of oral ubiquinone doses in rats
Authors: Abdullah Ali Ghanim , Sedeeq Ban Ismael , Azzubaidi Marwan Saad 
Published: December 2021

Abstract
Also called coenzyme Q10 (CoQ10), Ubiquinone is a vitamin-like endogenously produced factor essential for Adenosine triphosphate (ATP) mitochondrial production. Several research studies have reported that the exogenous supplementation of CoQ10 can lead to excessive salivation, especially in patients complaining of dry mouth. The objective of this study was to investigate the effect of long-term daily use of CoQ10 on the salivary glands in experimental animals by comparing the diameters of the glandular acini and striated ducts of a CoQ10-treated group and a control group. Twenty-five white albino rats were randomly divided into two groups; the control group consisted of 10 rats, while the CoQ10-treated group comprised 15 rats. The latter received daily oral treatment of 300 mg/kg CoQ10 for six weeks. Samples of the parotid, submandibular and sublingual glands were then dissected and examined histologically for comparative measurement of the diameters of the glands’ acini and striated ducts. The CoQ10 treated group had mean diameters of the serous acini for the parotid (79.8±11.2 μm) and submandibular (81.07±13.5 μm) glands that were significantly higher (P<0.05) than their diameters in the control group (67.5±8.4 μm and 73.3±13.8 μm), respectively. However, the difference was not statistically significant when comparing the diameters of striated ducts of the CoQ10-treated group and the control group. Continuous and prolonged exposure to exogenous ubiquinone may cause hypertrophic dilation of the acini within the salivary glands, namely the parotid and submandibular glands, which might be the underlying mechanism for excessive salivation. This can be considered a reversible adaptive response.
The role of leptin in patients recovering from Anorexia Nervosa
Authors: Rząd Zuzanna , Rog Joanna 
Published: December 2021

Abstract

Introduction: Anorexia nervosa (AN) is a mental disorder with the highest death rate. The characteristic feature of AN is endocrine dysregulations, including changes in adipose-tissue secreted hormones, especially adipokines. The most widely studied of them is leptin whose role in the pathophysiology and prognosis of AN is confirmed in more and more studies. The aim of the study was to summarize the role of endocrine disruptions with particular emphasis on leptin in the pathophysiology of AN.

Material and methods: For the literature review, the electronic databases PubMed, Cochrane and Google Scholar search were used with the following keywords: eating disorders, adipokines, leptin, metreleptin, satiety, hunger, anorexia, obesity, for studies listed from database inception to October 2021.

Results: Leptin, produced mainly by white adipose tissue, inhibits the hunger center in the hypothalamus by negative feedback with ghrelin secreted by the gastrointestinal tract. Leptin is involved in numerous biological functions, including body weight regulation, innate and adaptive immunity regulation, reproduction, and bone formation. Studies confirm decreased leptin levels in AN individuals. In recent years, extensive experience has been gained with leptin as a drug in clinical trials. The studies suggested that treatment can restore menstrual function and bone health and improve mood with unclear body weight effects.

Conclusions: Focusing on leptin-related changes is a promising approach to improve AN management. Assessment of leptin levels in AN patients could be a useful tool for therapy monitoring. Treatment with leptin could reverse unfavourable changes induced by diet restriction, including mood symptoms, loss of bone mass and menstrual function. However, the results of these studies need confirmation on larger groups of patients.
The Basics of a Mobile Money-Based Financial Service: Perceptions of University Students in Nigeria
Authors: Nwankwo Cosmas Anayochukwu , Kanyangale MacDonald Isaac , Abugu James Okechukwu 
Published: December 2021

Abstract
The purpose of this quantitative research was to investigate the basis and perception of mobile money (MM) service among Nigerian university students. The paper adopted a positivistic ontology and descriptive survey design. Two hundred and fifty students from five universities in the southeast geopolitical zone of Nigeria were sampled. Results showed that perceived ease of use (PEOU), perceived usefulness (PU), perceived credibility (PCRED), and perceived risk (PR) had significant and positive relationship with behavioral intention. Given the results, these four fundamental issues must be central to inclusive mobile money-based financial service for Nigerian university students. The adoption of the technology acceptance model (TAM) by mobile network operators (MNO) and banks is critical to ensure acceptance of innovative and inclusive mobile-based financial service and success in the university student market.
Estimation of heart rate variability from finger photoplethysmography during rest, mild exercise and mild mental stress
Authors: Singstad Bjørn-Jostein , Azulay Naomi , Bjurstedt Andreas , Bjørndal Simen S. , Drageseth Magnus F. , Engeset Peter , Eriksen Kari , Gidey Muluberhan Y. , Granum Espen O. , Greaker Matias G. , Grorud Amund , Hewes Sebastian O. , Hou Jie , Llop Recha Adrián M. , Matre Christoffer , Seputis Arnoldas , Sørensen Simen E. , Thøgersen Vegard , Joten Vegard Munkeby , Tronstad Christian , Martinsen Ørjan G. 
Published: December 2021

Abstract
Due to the possibilities in miniaturization and wearability, photoplethysmography (PPG) has recently gained a large interest not only for heart rate measurement, but also for estimating heart rate variability, which is derived from ECG by convention. The agreement between PPG and ECG-based HRV has been assessed in several studies, but the feasibility of PPG-based HRV estimation is still largely unknown for many conditions. In this study, we assess the feasibility of HRV estimation based on finger PPG during rest, mild physical exercise and mild mental stress. In addition, we compare different variants of signal processing methods including selection of fiducial point and outlier correction. Based on five minutes synchronous recordings of PPG and ECG from 15 healthy participants during each of these three conditions, the PPG-based HRV estimation was assessed for the SDNN and RMSSD parameters, calculated based on two different fiducial points (foot point and maximum slope), with and without outlier correction. The results show that HRV estimation based on finger PPG is feasible during rest and mild mental stress, but can give large errors during mild physical exercise. A good estimation is very dependent on outlier correction and fiducial point selection, and SDNN seems to be a more robust parameter compared to RMSSD for PPG-based HRV estimation.
Theology of Hope Amidst the World’s Fears
Authors: Zaluchu Sonny Eli 
Published: December 2021

Abstract
Fear is a social phenomenon that develops in people facing a crisis, such as a pandemic. For instance, the entire world is currently exposed to Covid-19 pandemic, causing great fear. In the Bible, Jesus’ disciples were terrified of sinking in their boat during a storm. Although these two scenarios are different, the response is the same. Fear produces stress and anxiety disorders when not appropriately managed. This paper examines the causes of fear and how they can be addressed. Specifically, the study involves determining the cause of fear and proposing a strategy based on Hope, as described by Erich in the book Revolution of Hope which positively correlates with building fortitude and endurance. Surrendering or persisting is a dialectical choice, though theology fear does not give chances. Instead, Humans only survive by depending on God. This research was involved literature reviews by utilizing reference sources, including books, journal articles, and other scientific content.
Influence of Recreational, Landscape and Protective Functions on the Value of Forest, Wooded and Bushy Properties in Urbanized Areas on the Example of the Local Market of the City of Krakow
Authors: Zygmunt Robert , Gaca Radosław 
Published: December 2021

Abstract
The paper presents a proposal for an approach to the valuation of forest, wooded and bushy real estate located in cities, which allows for the assessment of the impact of natural, protective and landscape factors on the value of this type of real estate. The main problem in the valuation of this type of real estate is the correct estimation of the impact on the value of the non-production factors described above. Considering the above, the main goal of the study was to identify the factors influencing the prices and value of forested, wooded and shrubby properties located in urbanized areas. The supplementary goal was to confirm the suitability of the methods and statistical models used in the study for similar measurements. By implementing the adopted goals, the article presents an analysis of the impact of these factors on the prices and value of real estate. The study covered the southwest part of the city of Kraków, located between the Vistula River and the Kraków-Rzeszów railway line in the north and east, and the southern and western border of the city. Urban forests perform mainly social functions, constituting only a marginal source of wood raw material. The results of the study showed that, in the case of similar properties, prices are significantly influenced by factors such as location, type and nature of the surroundings, form of access to the road, landscape and recreational values, manner of use and development status, as well as the permissible form of development, which is a measure of the profitability of timber production. The work ended with a discussion on the results and proposed directions for further research.
The Effect of Hybrid Attributes on Property Prices
Authors: Copiello Sergio , Cecchinato Filippo , Haj Salih Mohammed 
Published: December 2021

Abstract
This study focuses on the sales comparison and the adjustment grid methods, under the framework of the market approach to valuation. The literature mostly focuses on the structural qualities of the properties, referring to the buildings and their locational characteristics, which pertain to their positioning within the urban fabric. Here we focus on a particular set of attributes which depend on how a building is placed in a specific land plot and relate to the surrounding environment. The term «hybrid» is used to identify this class of attributes. It is shown that hybrid attributes affect property prices and should not be disregarded by practitioners and appraisers. The role played by hybrid characteristics is analyzed based on the methodological foundation of the hedonic and the adjustment grid methods. The derived linear and log-linear models are tested by means of a case study. The models prove to have high explanatory power. The weight of each hybrid attribute is estimated to vary between 1% and 10%. Overall, these attributes contribute to 17-23% of the property prices. The validation performed using the grid adjustment method shows that the estimated marginal prices are effective in adjusting the prices per unit area of the comparables.
Bioresource Value Model. Case of Fisheries
Authors: Zihare Lauma , Indzere Zane , Patel Nidhiben , Feofilovs Maksims , Blumberga Dagnija 
Published: December 2021

Abstract
The awareness of bioeconomy role within currently set EU policy targets towards zero carbon emissions and its contribution to achieving the sustainable development goals has been increasing during the last decade. However, it is not always straightforward how the development scenarios for bioeconomy can be evaluated on national level. Moreover, the large number of factors affecting the development of bioconomy is hard to evaluate altogether. Therefore, this study reviews currently available tools for bioresource value modelling in order to select an approach that is suitable for modelling different scenarios of bioeconomy development. As a result of the review, the study presents a methodology, which allows to estimate how higher added values of bioresource products can be achieved in different bioeconomy sectors. The concept of model is tested within a case study of fisheries sector in Latvia. The results of case study show economically viable scenario for added value target set for 2030. The concept of model is found to be adequate, and the use of the defined methodology is appropriate for bioresource value modelling.
С.А. ТЕПЛОУХОВ И ГЕРО ФОН МЕРГАРТ: ДИАЛОГ ДЛИНОЮ В ВЕК
Authors: Детлова Екатерина Владимировна 
Published: December 2021

Статья посвящена диалогу двух ведущих археологов-сибиреведов 1920-х гг. С.А. Теплоухова и Геро фон Мергарта. Общение ученых, к сожалению, непродолжительное (оно ограничилось двумя личными встречами в 1920–1921 гг. и шестью письмами 1920–1929 гг.), тем не менее, было плодотворным. Итогом его стало создание С.А. Теплоуховым известной хронологической схемы древних культур Южной Сибири, которая в общих чертах остается актуальной и сегодня. Российско-германское сотрудничество, начатое учеными летом 1920 г., продолжилось в совместной работе их учеников. Отголоски этих контактов дошли до наших дней.
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