bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan dan Pelatihan Stimulasi Periode Emas Anak 1000 HPK di Wilayah Puskesmas Sipoholon, Kabupaten Tapanuli Utara Tahun 2019
Authors: Pakpahan Sulastry 
Published: June 2021

National data according to the Indonesian Ministry of Health in 2015, 11.5% of children under five in growth and development of abnormalities. Knowledge and awareness of the importance of stimulation of growth and development during the 1000 HPK period is needed so that parents can take advantage of this period to form children who have intellectual, emotional, language, creative and positive character. Activities carried out by providing counseling to pregnant women, mothers or husbands with toddlers and training to health cadres. The implementation of the activity lasts 3 days, divided into 2 stages, namely day 1-2 is the implementation of health education and day 3 is the implementation of training. The number of health education participants was 57 people and training participants were 48 people. Each participant was given a questionnaire to measure the increase in knowledge after the implementation of the activity. The results of this activity was obtained that the participants' knowledge increased by 24.56% in very good categories, 22.8% in good categories, and 43.38% in adequate categories. The increase in the knowledge of the training participants in the very good category increased by 27.1%, the good category was 20.8% and the moderate category was 47.9%. Health education and training about growth and development stimulation during the 1000 HPK period can increase knowledge and awareness of mothers, families and health cadres so they are expected to be able to apply the knowledge received during the training in everyday life and to the surrounding community.
Technical Note: Electrochemical Testing for Pitting Corrosion Above Ambient Temperatures Using the Syringe Cell
Authors: Panindre A.M. , Frankel G.S. 
Published: June 2021

The syringe cell method has been further developed to evaluate the temperature dependence of pitting corrosion in passive alloys that pit above ambient temperature without artifacts associated with crevice corrosion. The pitting potential of commercially available duplex stainless steel type 2205 was measured at different temperatures by using a hot plate to heat the specimen. Breakdown potentials decreased by about 1 V at test temperatures above 50°C. The critical pitting temperature (CPT) of the alloy was determined to be between 54°C and 59°C by scanning the temperature of the specimen surface during constant potential holds. In all experiments, pits were observed in the area defined by the electrolyte droplet in contact with the specimen surface. Using a more conventional approach mentioned in ASTM Standard G48 Method C, the CPT of the alloy was determined to be 55°C.
Rituele normen
Authors: Peels-Matthey Saskia 
Published: June 2021

AbstractThis article is an introduction to a group of Ancient Greek inscriptions that may be called ‘ritual norms’ (also known asleges sacrae, ‘sacred laws’). These are epigraphical documents concerning rituals that are performed in the context of specific cults, and which are of a prescriptive character. The article discusses three key questions. In the first part of the article I aim to answer a basic question: what are ritual norms? The second question concerns the function of ritual norms. The third part of the article is about the way in which ritual norms acquire authority. How were they considered legitimate and enforceable? A separate section concerning authority is reserved for the use of tradition (anchoring and anchoring innovation) in this genre.
Harnessing stratospheric diffusion barriers for enhanced climate geoengineering
Authors: Aksamit Nikolas O. , Kravitz Ben , MacMartin Douglas G. , Haller George 
Published: June 2021

Abstract. Stratospheric sulfate aerosol geoengineering is a proposed method
to temporarily intervene in the climate system to increase the reflectance of shortwave radiation and reduce mean global temperature. In previous climate modeling studies, choosing injection locations for geoengineering aerosols has, thus far, only utilized the average dynamics of stratospheric wind fields instead of accounting for the essential role of time-varying material transport barriers in turbulent atmospheric flows. Here we conduct the first analysis of sulfate aerosol dispersion in the stratosphere, comparing what is now a standard fixed-injection scheme with time-varying injection locations that harness short-term stratospheric diffusion barriers. We show how diffusive transport barriers can quickly be identified, and we provide an automated injection location selection algorithm using short forecast and reanalysis data. Within the first 7 d days of transport, the dynamics-based approach is able to produce particle distributions with greater global coverage than fixed-site methods with fewer injections. Additionally, this enhanced dispersion slows aerosol microphysical growth and can reduce the effective radii of aerosols up to 200–300 d after injection. While the long-term dynamics of aerosol dispersion are accurately predicted with transport barriers calculated from short forecasts, the long-term influence on radiative forcing is more difficult to predict and warrants deeper investigation. Statistically significant changes in radiative forcing at timescales beyond the forecasting window showed mixed results, potentially increasing or decreasing forcing after 1 year when compared to fixed injections. We conclude that future feasibility studies of geoengineering should consider the cooling benefits possible by strategically injecting sulfate aerosols at optimized time-varying locations. Our method of utilizing time-varying attracting and repelling structures shows great promise for identifying optimal dispersion locations, and radiative forcing impacts can be improved by considering additional meteorological variables.
Tussenkroniek rechtspraak strafrecht
Authors: Mevis P.A.M. , Postma L. 
Published: June 2021

Tussenkroniek rechtspraak strafrecht. Euthanasie op basis van een schriftelijke wilsverklaring
In het onderstaande wordt de gang van zaken in de Koffie-euthanasiezaak betreffende euthanasie op basis van een schriftelijke wilsverklaring op een rij gezet. Enkele onderdelen daarvan worden van enig commentaar voorzien. Daarnaast wordt aandacht besteed aan de herziene versie van de EuthanasieCode 2018 en RTE-oordelen met betrekking tot euthanasie bij dementie op basis van een schriftelijke wilsverklaring uit de periode ná de beslissingen van de Hoge Raad van 21 april 2020. De conclusie is dat euthanasie op basis van een schriftelijke wilsverklaring van een eigen, op deze modaliteit toegesneden wettelijke regeling moet worden voorzien. Een voorstel daartoe is voorhanden.
Prediction of hERG inhibition of drug discovery compounds using biomimetic HPLC measurements
Authors: Stergiopoulos Chrysanthos , Tsopelas Fotios , Valko Klara 
Published: June 2021

The major causes of failure of drug discovery compounds in clinics are the lack of efficacy and toxicity. To reduce late-stage failures in the drug discovery process, it is essential to estimate early the probability of adverse effects and potential toxicity. Cardiotoxicity is one of the most often observed problems related to a compound's inhibition of the hERG channel responsible for the potassium cation flux. Biomimetic HPLC methods can be used for the early screening of a compound's lipophilicity, protein binding and phospholipid partition. Based on the published hERG pIC50 data of 90 marketed drugs and their measured biomimetic properties, a model has been developed to predict the hERG inhibition using the measured binding of compounds to alpha-1-acid-glycoprotein (AGP) and immobilised artificial membrane (IAM). A representative test set of 16 compounds was carefully selected. The training set, involving the remaining compounds, served to establish the linear model. The mechanistic model supports the hypothesis that compounds have to traverse the cell membrane and bind to the hERG ion channel to cause the inhibition. The AGP and the hERG ion channel show structural similarity, as both bind positively charged compounds with strong shape selectivity. In contrast, a good IAM partition is a prerequisite for cell membrane traversal. For reasons of comparison, a corresponding model was derived by replacing the measured biomimetic properties with calculated physicochemical properties. The model established with the measured biomimetic binding properties proved to be superior and can explain over 70% of the variance of the hERG pIC50 values.
©2021 by the authors. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Implementing Research Data Management Services in a Canadian Context
Authors: Grynoch Tess 
Published: June 2021

Research data management (RDM) has become an increasingly pressing issue for academic libraries as they strive to assist researchers in addressing new public funding requirements surrounding data dissemination and preservation. Briney, Goben, & Zilinski (2015) reviewed several characteristics of RDM service provision efforts by 206 American research universities. Following a similar methodology, the author reviewed RDM service development within Canadian research universities and compared the results to the American efforts. The main area requiring development in Canada is the provision of RDM services. Therefore, some current best practices for implementing RDM services were gathered through a literature review. The successful approaches highlighted in the literature include awareness of funder and institutional data policies, reaching out to data service providers on campus and beyond, understanding researcher data management needs and finding RDM champions, implementing research data services strategically, planning for growth in RDM services, marketing the RDM services, and creating incentives to create data management plans and utilize RDM services. Third Place DJIM Best Article Award.
Blockchain Tracking and Cannabis Regulation: Developing a permissioned blockchain network to track Canada's cannabis supply chain
Authors: Abelseth Brian 
Published: June 2021

Achieving government’s goals for cannabis regulation requires legal cannabis to be a cheaper, more attractive consumer alternative compared to the illegal market. This goal may be undermined by the costs and disadvantages of traditional regulatory management. A Canada wide, real-time blockchain tracking system appears to be a viable technical solution architecture. A permissioned blockchain network could be tested alongside traditional tracking. This investment, if proven effective, could reduce regulatory costs for government and red tape for business, helping to achieve Governments’ objectives to:Enhance public safety by ensuring quality and monitoring product salesUndermine illegal markets to reduce crime and prevent product diversion
Rho‐dependent transcription termination regulates the toxin–antitoxin modules of cryptic prophages to silence their expression in Escherichia coli
Authors: Hafeezunnisa Mohammed , Chhakchhuak Passong Immanual R. , Krishnakumar Janani , Sen Ranjan 
Published: June 2021

Bacterial Rho‐dependent transcription termination regulates many physiological processes. Here, we report that it controls the expression of toxin–antitoxin (TA) modules of cryptic prophages in E. coli. Microarray profiles of Rho mutants showed upregulation of genes of the CP4‐6 and CP4‐44 prophages, including their TA modules, that were validated by RT‐qPCR. Analysis of the in vivo termination efficiency and the mRNA sequences of these prophages revealed the presence of many Rho‐dependent terminators. The prophage TA modules exhibited synthetic lethality with the Rho mutants, indicating functional involvement of Rho‐dependent termination in controlling these modules. Rho‐dependent termination does not regulate most of the chromosomal TA modules. We conclude that Rho‐dependent termination specifically silences the TA modules of prophages, thereby augmenting bacterial innate immunity.
Field research on cyclone damage and housing reconstruction in Fijian Village—Case study of Navala Village after tropical cyclone Winston
Authors: Miyaji Mari , Fujieda Ayako , Veitata Sainimere , Kobayashi Hirohide 
Published: June 2021

AbstractThe Republic of Fiji was hit by Tropical Cyclone Winston in 2016, and housing reconstruction was enabled through government support. This study was aimed at observing the impact on housing in a rural village consisting of both modern and traditional housing types, as well as identifying the reconstruction process. The results show that the distribution of materials was delayed, and housing quality depended on local carpenters. We concluded that there was a need to train carpenters, and the reconstruction of traditional houses should be considered. This is to reflect the natural environment in tropical islands and enhance traditional building knowledge.
Tough Choices: Exploring Medication Decision‐Making During Pregnancy and Lactation Among Women With Inflammatory Arthritis
Authors: Birru Talabi Mehret , Eudy Amanda M. , Jayasundara Malithi , Haroun Tayseer , Nowell W. Benjamin , Curtis Jeffrey R. , Crow‐Hercher Rachelle , White Whitney , Ginsberg Seth , Clowse Megan E. B. 
Published: June 2021

ObjectiveThis study explored how women’s beliefs about drug safety and interactions with their health care providers influenced their decisions to continue arthritis medications during pregnancy and lactation.MethodsWe collaborated with ArthritisPower, a patient‐powered research network, and CreakyJoints, its partner online community, to develop and disseminate a survey among members with inflammatory arthritis who had at least one pregnancy after diagnosis. Participants’ free‐text responses were evaluated by using thematic analysis.ResultsWomen in the sample were 40 years old on average (N = 66). Nineteen of their pregnancies had ended in fetal loss. Fifteen percent of all pregnancies were exposed to methotrexate. Among women who used safe arthritis medications, up to 80% discontinued treatment either in preparation for pregnancy or during pregnancy or lactation. Women’s decisions to continue medications during pregnancy were influenced by their perceptions of safety and advisement from health care providers, although they often described that advice about medication safety was inconsistent between providers.ConclusionWomen often chose to endure active inflammatory arthritis rather than to use disease‐modifying antirheumatic drugs because of concerns about medication safety during pregnancy and lactation. Conflicting medical advice from health care providers undermined patients’ trust in their providers and in the safety of their medications. The high rate of peripartum exposure to methotrexate, a fetotoxic drug, underscores the need for better family planning care for women with childbearing potential.
Light‐Regulated Angiogenesis via a Phototriggerable VEGF Peptidomimetic
Authors: Nair Roshna V. , Farrukh Aleeza , del Campo Aránzazu 
Published: June 2021

AbstractThe application of growth factor based therapies in regenerative medicine is limited by the high cost, fast degradation kinetics, and the multiple functions of these molecules in the cell, which requires regulated delivery to minimize side effects. Here a photoactivatable peptidomimetic of the vascular endothelial growth factor (VEGF) that allows the light‐controlled presentation of angiogenic signals to endothelial cells embedded in hydrogel matrices is presented. A photoresponsive analog of the 15‐mer peptidomimetic Ac‐KLTWQELYQLKYKGI‐NH2 (abbreviated PQK) is prepared by introducing a 3‐(4,5‐dimethoxy‐2‐nitrophenyl)‐2‐butyl (DMNPB) photoremovable protecting group at the Trp4 residue. This modification inhibits the angiogenic potential of the peptide temporally. Light exposure of PQK modified hydrogels provide instructive cues to embedded endothelial cells and promote angiogenesis at the illuminated sites of the 3D culture, with the possibility of spatial control. PQK modified photoresponsive biomaterials offer an attractive approach for the dosed delivery and spatial control of pro‐angiogenic factors to support regulated vascular growth by just using light as an external trigger.
Design of Hybrid Superwetting Surfaces with Self‐Driven Droplet Transport Feature for Enhanced Condensation
Authors: Tang Yu , Yang Xiaolong , Li Yimin , Zhu Di 
Published: June 2021

AbstractPatterned hybrid superwetting surfaces that function in drop‐film‐wise condensation mode have great potential applications in heat transfer devices, water desalination, etc., due to the high performance of condensate transport. However, design and combination strategy for pattern optimization are still not clear. In this work, superhydrophobic surfaces with wedge‐shaped superhydrophilic patterns are created for enhanced condensation. Dependence of geometry, size, and combination of the patterns on droplet transporting and heat transfer coefficient is investigated. Results imply that superhydrophobic surface with array of single‐wedge‐shaped superhydrophilic patterns shows 30% improvement of heat transfer coefficient when compared with superhydrophobic surface, due to rapid condensate transferring from drop‐wise to film‐wise region, condensate converging and departing from the film‐wise region. Additionally, when compared with the surface with array of cluster‐wedge‐shaped superhydrophilic patterns, the surface with array of single‐wedge‐shaped superhydrophilic patterns have higher condensation efficiency because of the larger total circumference, which donate greater condensate transferring capacity. Moreover, single‐wedge‐shaped superhydrophilic patterns with large size show higher heat transfer coefficient than the patterns with small size due to lower saturated vapor pressure. This new fundamental insight can be used to develop new hybrid superwetting surfaces intended on engineering applications, such as water production and heat transfer.
Z‐Scheme Flower‐Like SnO2/g‐C3N4 Composite with Sn2+ Active Center for Enhanced Visible‐Light Photocatalytic Activity
Authors: Bao Zhiyong , Xing Mengmeng , Zhou Yu , Lv Jun , Lei Dangyuan , Zhang Yong , Cai Jing , Wang Jiaheng , Sun Zhenjie , Chen Wenjuan , Gan Xiaorong , Yang Xingyu , Han Qizhen , Zhang Maofeng , Dai Jiyan , Wu Yucheng 
Published: June 2021

AbstractThe invention of defect‐engineering motivated Z‐scheme photocatalytic complexes has been treated as an emerging opportunity to accomplish effective carrier separation and electron transfer in hybrid heterojunctions, contributing a novel approach to accomplish modified visible‐light driven photocatalytic performance compared to traditional nanocomposites. Exploring a desired carrier medium is crucial to support impressive electron transportation in Z‐scheme photocatalytic nanocomposites. Here, the role that the Sn2+/Sn4+ redox couple plays in the photocatalytic process is systematically studied by taking the flower‐like SnO2/layered g‐C3N4 with deficient Sn2+ reactive sites as an example, where the defect‐engineering can be introduced by heat treatment. The experimental results and computational simulations demonstrate that the deficient Sn2+ reactive sites can facilitate small molecule adsorption and boost the interfacial carrier separation and transfer in the photocatalytic procedure by bringing in the Sn2+/Sn4+ redox couple. This work provides a more in‐depth exploration of Z‐scheme photocatalytic‐system construction and is helpful to the development of defect‐engineering approaches with high photocatalysis performance.
Co‐Evaporated Perovskite Light‐Emitting Transistor Operating at Room Temperature
Authors: Klein Maciej , Li Jia , Bruno Annalisa , Soci Cesare 
Published: June 2021

AbstractSolution‐processed hybrid organic–inorganic perovskite light‐emitting transistors (PeLETs) suffer from low brightness and environmental instability induced by temperature‐activated trapping, ionic motion, and polarization effects, which so far have been hindering the realization of devices operating at room temperature. Here high quality thermally co‐evaporated methylammonium lead iodide perovskite films are employed to minimize ionic motion and significantly improve the electroluminescence characteristics of the perovskite active layer, enabling stable device operation up to ≈ 310 K. The demonstration of PeLETs operating at and beyond room‐temperature paves the way for practical applications in the rapidly evolving area of solid‐state lighting, active‐matrix displays, and visible light communications.
Measurements of lethal and nonlethal inbreeding depression inform the de novo domestication of Silphium integrifolium
Authors: Price John H. , Brandvain Yaniv , Smith Kevin P. 
Published: June 2021

PREMISEInbreeding depression, or the reduction in fitness of progeny with related parents, has the potential to adversely affect the long‐term viability of both wild and captive plant populations. Silphium integrifolium, a prairie plant native to the central United States, has been identified as a potential candidate for domestication as a perennial oilseed crop. Little is known about the potential for inbreeding depression in this species, but it is expected to be nonnegligible because S. integrifolium is both perennial and self‐incompatible. Here, we measure lethal inbreeding depression expressed through embryo deaths, and nonlethal inbreeding depression expressed through changes in vigor and fitness phenotypes of progeny.METHODSFirst, we made controlled crosses among related and unrelated individuals to determine the effect of two different levels of inbreeding on seed production. Then, we grew inbred and outbred progeny from this population to reproductive maturity and measured 11 key traits.RESULTSWe found that within an improved S. integrifolium population, individuals carried an average of slightly less than one lethal allele per gamete. In progeny, significant inbreeding depression was observed in at least one family for eight of the 11 measured traits.CONCLUSIONSInbreeding depression is likely to be an important challenge to S. integrifolium domestication, reducing overall population fecundity and values for important phenotypes. These effects may grow worse as selection reduces effective population size. We recommend several strategies for S. integrifolium breeding to help mitigate these problems.
Electric Dipole Polarizability of Neutron Rich Nuclei
Authors: Piekarewicz Jorge 
Published: June 2021

AbstractInsights into the equation of state of neutron rich matter obtained from the neutron skin thickness of208Pb are in sharp conflict with earlier measurements of the electric dipole polarizability. A set of accurately calibrated energy density functionals are used to highlight the tension and to articulate how a highly‐intense Gamma Factory may help resolve the present dilemma.
Nickel‐Catalyzed Thiolation of Aryl Nitriles
Authors: Delcaillau Tristan , Morandi Bill 
Published: June 2021

AbstractA nickel‐catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2‐bis(dicyclohexylphosphino)ethane) as well as the base KOtBu (potassium tert‐butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C−C bond activation and a C−S bond formation. Furthermore, this reaction shows a high functional‐group tolerance and enables the late‐stage functionalization of important molecules.