bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and interaction analysis of the tumor necrosis factor-alpha with oligopeptides
Authors: Ryabtseva T. V. , Makarevich D. A. , Taganovich A. D. 
Published: November 2021

The aim of the study was the design, characteristics and analysis of the TNFα interaction with oligopeptideanalogs of the interaction site of TNFα with TNFα-R2. Here are the results of the analysis contact zone of TNFα with TNFα-R2, determination of the potentially most effective oligopeptides, study of the binding free energy of oligopeptides and its changes depending on the number of amino acid residues in the peptide chain, as well as the TNFα form (monomer or trimer). Here are described the most typical loci of oligopeptides interaction with cytokine. To confirm the calculations, the effectiveness of the selected oligopeptides was evaluated in experiments in vitro.For visualization of the molecular complex and work with the pdb file we are used Chimera 1.14 software with AutoDocVina utility. For in vitro studies, were used indirect enzyme immunoassay reagent kits. The initial concentration of oligopeptides is 10 µM, the initial concentration of TNFα (×10–8): 0; 0.0287; 0.0862; 0.2300; 0.5750; 1.4370 µM. When oligopeptides interact with mTNFα, the binding efficiency increase was observed with an increase in the number of amino acid residues in the chain. With tTNFα, such dependence was not observed. A statistically significant difference was observed in the binding energy of di-, tri-, and tetra peptides with mTNFα, with tTNFα, the differences found were not statistically significant.Thus, the data were obtained, which allowed us to come to the following conclusions: 1) the energy of interaction of oligopeptides with tTNFα does not depend on the number of amino acid residues in the oligopeptide; 2) the trimerized form of TNFα interacts most effectively with oligopeptides in comparison with mTNFα; 3) oligopeptides containing the -Trp- and being a spatial analogue of the TNFα-R2 fragment (-Trp65-Asn66-Trp67-Val68-Pro69-) interact most effectively; 4) it was selected three oligopeptides are the most promising for the binding of TNFα. The experiments in vitro confirmed the effectiveness only one oligopeptide
PKM Pengembangan Kawasan Pertanian Hidroganik Padi “Bengkel Mimpi” Menggunakan Sumber Energi Mandiri Fotovoltaik
Authors: Budiyanto Hery , Setiawan Aries Boedi , Siswati Aris 
Published: November 2021

Saat ini ada cara lain untuk memanfaatkan lahan sempit sebagai usaha untuk mengembangkan hasil pertanian, yaitu dengan cara bercocok tanam secara Hidroganik yaitu sistem budidaya organik dengan menanam padi pada tanah humus di dalam gelas plastik yang ditanam pada jajaran pipa paralon diatas kolam ikan, memadukan sistem hidro (sirkulasi air bernutrisi) dan sistem organik (tanpa pupuk kimia). Sumber nutrisi utama dari hidroganik ini diperoleh dari pupuk organik padat dan cair serta air kolam yang di-treatment sebagai nutrisi tanaman. Program Kemitraan Masyarakat (PKM) ini bertujuan untuk menangani permasalahan yang dialami oleh mitra pengabdian yaitu Pusat Pelatihan Pertanian dan Pedesaan Swadaya “Bengkel Mimpi” di Dusun Krajan Desa Kanigoro RT 33 RW 03 Kecamatan Pagelaran Kabupaten Malang yang melakukan budidaya padi secara hidroganik. Masalahnya adalah bagaimana mendapatkan sumber tenaga listrik alternatif agar pengeluaran keuangan untuk listrik yang selama ini hanya dari PLN dapat lebih dihemat/dikurangi, sehingga solusi dan target luaran yang dilaksanakan dalam mengatasi permasalahan tersebut berupa pembangkit listrik tenaga surya (PLTS) yang digunakan untuk menggerakkan 12 buah pompa air hidroganik dan 2 buah lampu penerangan jalan di kawasan “Bengkel Mimpi”. Setelah melalui perhitungan teknis, dipasang 6 buah solar panel 100 wp lengkap dengan bracket penyangga, 3 buah battery 100 AH, 1 buah solar charge controller, 1 buah inverter 3000 WA, 12 buah pompa air. Kelebihan dari PLTS ini adalah aspek desain bracket penyangga solar panel yang dibuat atraktif menyerupai bentuk bunga matahari. Hasil pengujian telah dilakukan dalam kondisi cerah PLTS ini menghasilkan 2.144 WattJam. Luaran PKM ini dapat dijadikan sebagai model sumber tenaga listrik alternative di desa-desa lain secara nasional terutama pada lahan-lahan pertanian hidroganik maupun hidroponik yang lokasinya jauh dari jaringan listrik PLN.
IbM Pemantapan Pengelolaan Sistem Pencatatan Keuangan IKM N'Up Product
Authors: Ekawati Yurida , Purnomo Purnomo , Noya Sunday , Putrianto Novenda Kartika , Oktiarso Teguh , Hadi Yuswono 
Published: November 2021

Perkembangan jumlah UKM di Indonesia semakin pesat. Namun dari sekian banyak UKM, sebagian besar masih mengalami kesulitan yang berhubungan dengan pengelolaan keuangan usaha. Hal ini tidak lepas dari keterbatasan UKM untuk memiliki pengetahuan yang baik tentang pengelolaan dan pencatatan keuangan serta keterbatas akses UKM untuk mendapatkan aplikasi pengelolaan dan pencatatan keuangan sederhana yang sesuai dengan kondisi usaha mereka. Kondisi ini dialami juga oleh N’Up Product, sebuah IKM yang memproduksi produk-produk olahan bawang hitam. Keterbatasan akses dan pengetahuan, mengakibatkan pencatatan keuanganya masih dilakukan secara manual. Membantu mengatasi persoalan ini, Tim Pengabdian Masyarakat Prodi Teknik Industri Universitas Ma Chung, melalui Skim Ma Chung Abdimas Grant (MAG), merancang aplikasi khusus pencatatan keuangan IKM yang berbasiskan Microsoft Excel. Aplikasi ini kemudian diterapkan di IKM N’Up Product sekaligus untuk memperbaiki cara pengelolaan keuangannya. Hasil yang didapatkan melalui program ini, IKM N’Up Product telah memiliki dan menerapkan sebuah sistem pengelolaan dan pencatatan keuangan yang professional, yang pada saatnya nanti akan membantu pengembangan dan peningkatan usahanya.
Penerapan Six Sigma untuk Peningkatan Kualitas Packing pada Minyak Goreng Pouch PT. XYZ di Kabupaten Gresik
Authors: Rahmat Rahmatulloh , Utomo Yitno 
Published: November 2021

Kualitas kemasan sangat berpengaruh terhadap pendistribusian hasil produksi kepada pelanggan. Apabila kemasan mengalami kerusakan atau cacat ketika produksi, maka produk tersebut tidak dapat didistribusikan kepada konsumen. Oleh karena itu, kualitas dari kemasan harus dijaga untuk keberhasilan pemasaran produk. Hal ini berlaku untuk setiap pruduk tidak terkecuali produk minyak goreng dengan kemasan pouch. Pada proses packingnya kemasan pouch sering mengalami kendala atau cacat sehingga dapat merugikan perusahaan. Tujuan dari penelitian ini untuk mengetahui hasil analisis six sigma sebelum diterapkannya DMAIC, dan mengetahui hasil analisis implementasi six sigma sesudah diterapkannya DMAIC. Pengambilan sampel dalam penelitian ini menggunakan teknik purposive sampling, yang diambil selama 30 hari. Data dalam penelitian ini diperoleh melalui wawancara, dan observasi saat penelitian berlangsung dimana kehadiran peneliti sangat diperlukan dalam penelitian ini. Teknik Analisis yang digunakan yaitu dengan metode DMAIC. Define, mengidentifikasi masalah guna mengetahui sumber permasalahan dan pembuatan diagaram IPO; Measure, melakukan pengukuran menggunakan diagram control P-chart dan menganalisa tingkat DPMO; Analyze, mengidentifikasi penyebab dengan menggunakan diagram pareto dan diagram tulang ikan; Improve, rekomendasi usulan perbaikan; Control, mengevaluasi hasil kinerja dalam kondisi standart dan terjaga nilai-nilai peningkatannya. Hasil penelitian menunjukkan sebelum dilakukan perbaikan nilai sigma yang didapat yaitu 3,99 sigma dengan nilai DPU sebesar 0,006434 dan DPMO sebesar 6.364. Terdapat 4 jenis defect yang masuk dalam CTQ yaitu bocor, isi kurang, kemasan rusak, dan expired date tidak ada. Setelah melakukan 9 tindakan perbaikan diperoleh nilai sigma seberas 4,18 dengn nilai DPU sebesar 0,003655 dan DPMO sebesar 3.655
Simulation of Nanofluid Flow in a Micro-Heat Sink With Corrugated Walls Considering the Effect of Nanoparticle Diameter on Heat Sink Efficiency
Authors: Khetib Yacine , Abo-Dief Hala M. , Alanazi Abdullah K. , Cheraghian Goshtasp , Sajadi S. Mohammad , Sharifpur Mohsen 
Published: November 2021

In this numerical work, the cooling performance of water–Al2O3 nanofluid (NF) in a novel microchannel heat sink with wavy walls (WMH-S) is investigated. The focus of this article is on the effect of NP diameter on the cooling efficiency of the heat sink. The heat sink has four inlets and four outlets, and it receives a constant heat flux from the bottom. CATIA and CAMSOL software were used to design the model and simulate the NF flow and heat transfer, respectively. The effects of the Reynolds number (Re) and volume percentage of nanoparticles (Fi) on the outcomes are investigated. One of the most significant results of this work was the reduction in the maximum and average temperatures of the H-S by increasing both the Re and Fi. In addition, the lowest Tmax and pumping power belong to the state of low NP diameter and higher Fi. The addition of nanoparticles reduces the heat sink maximum temperature by 3.8 and 2.5% at the Reynolds numbers of 300 and 1800, respectively. Furthermore, the highest figure of merit (FOM) was approximately 1.25, which occurred at Re=1800 and Fi = 5%. Eventually, it was revealed that the best performance of the WMH-S was observed in the case of Re=807.87, volume percentage of 0.0437%, and NP diameter of 20 nm.
Analysis of Risk Factors and Establishment of a Prediction Model for Endoscopic Primary Bile Reflux: A Single-Center Retrospective Study
Authors: Chen Li , Zhu Guoying , She Ling , Ding Yongnian , Yang Changqing , Zhu Fengshang 
Published: November 2021

Background: Endoscopic primary bile reflux is one of the main diagnostic criteria for bile reflux gastritis (BRG). Presently, the risk factors and prediction models of endoscopic primary bile reflux (EPBR) in gastropathy patients who cannot or will not undergo endoscopy due to contraindications are not clear. Thus, this study aimed to evaluate the risk factors of EPBR and to establish and verify a prediction model.Methods: A series of 844 patients (564 subjects with EPBR and 280 control subjects) were retrospectively selected for this study and divided into a training set (n = 591) and a validation set (n = 253) according to the usual ratio of 70:30% for the subsequent internal validation of the logistic regression model for EPBR. Fifteen parameters that might affect the occurrence of EPBR were collected. Subsequently, univariate and stepwise logistic regression analyses were introduced to reveal the risk factors and the multivariate prediction model. An R package was dedicated to the corresponding internal validation of the EPBR model.Results: The univariate analysis showed that gender, age, smoking, Helicobacter pylori (H. pylori) infection status, metabolic syndrome (MS), non-steroidal anti-inflammatory drugs (NSAIDs) use history, and previous medical histories of chronic liver diseases, cholelithiasis, and erosive gastritis were statistically significant between the two groups (P &lt; 0.05). Multivariate regression described that being a male [OR (95%confidence interval (CI)) = 2.29 (1.50–3.50), P &lt; 0.001], age≥45 years old [OR (95% CI) = 4.24 (2.59–6.96), P &lt; 0.001], H. pylori infection status [OR (95% CI) = 2.34 (1.37–4.01), P = 0.002], MS [OR (95% CI) = 3.14 (1.77–5.54), P &lt; 0.001], NSAIDs use history [OR (95% CI) = 1.87 (1.03–3.40), P = 0.04], cholelithiasis history [OR (95% CI) = 3.95 (2.18–7.18), P &lt; 0.001] and erosive gastritis history [OR (95% CI) = 6.77 (3.73–12.29), P &lt; 0.001] were the risk factors for the occurrence of EPBR. Based on the results of these risk factors, an EPBR prediction model with an adequate calibration and excellent discrimination was established [area under the curve (AUC): 0.839, 95% CI = 0.806–0.872].Conclusions: Being a male, age ≥ 45 years old, H. pylori infection, histories of MS, NSAIDs use, cholelithiasis, and erosive gastritis appear to be the risk factors for EPBR, and our favorable prediction model might be an option for the prediction of EPBR.
Weekly Variations of Intracerebral Hemorrhage Occurrence Among Different Populations: A Cross-Sectional Study
Authors: Pu Yun-Tao , Yan Ning , Wang En-Yuan , Wang Yan-Yue 
Published: November 2021

Background and purpose: The causes of the higher incidence of intracerebral hemorrhage (ICH) on a given day are unclear. Previous studies have shown that it may vary by region and population. The purpose of this study was to detect weekly variations in ICH occurrence in southwest China and to assess differences in ICH occurrence among different populations.Methods: This hospital-based study included patients with first-onset ICH that occurred from January 1, 2012, to December 31, 2019. The weekly variation in ICH occurrence was analyzed and stratified by sex, age, comorbidities, living habits, and residence.Results: A total of 5,038 patients with first-onset ICH were enrolled. ICH occurrence was higher on Monday [odds ratio (OR), 1.22; 95% CI, 1.09–1.36; P &lt; 0.001] and Friday (OR, 1.15; 95% CI, 1.03–1.28; P &lt; 0.001) among all patients, and this pattern was consistent with that of men, whereas women showed a higher incidence on Mondays, Saturdays, and Sundays. The increase in the number of ICH events on Monday and Friday was pronounced in the age range of 41–60 years; however, no significant weekly variation in ICH occurrence was observed among other age groups. After stratifying by comorbidities, a significant weekly variation in ICH occurrence was observed in patients with hypertension or diabetes. Smoking and alcohol consumption was associated with a higher incidence of ICH on Friday; otherwise, a Monday excess was observed. The urban population demonstrated a significant weekly variation in ICH occurrence, whereas the rural population did not.Conclusions: Intracerebral hemorrhage occurrence showed weekly variations in southwest China and was significantly affected by sex, age, comorbidities, living habits, and residence. This suggests that weekly variations in ICH occurrence maybe dependent on the region and population.
Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study
Authors: Im Jooyeon J. , Jeong Hyeonseok , Kim Young Do , Jang Kyung-Sool , Song In-Uk , Chung Yong-An 
Published: November 2021

Objective: Clinical and radiological findings on neurosyphilis are fairly non-specific and there is a paucity of functional neuroimaging studies on neurosyphilis other than case reports and case series. The purpose of this study was to investigate brain perfusion abnormalities in patients with neurosyphilis.Methods: Four HIV-negative neurosyphilis patients and 4 healthy controls underwent clinical evaluation, brain technetium-99m ethyl cysteinate dimer (99mTc-ECD) single-photon emission computed tomography (SPECT) imaging, and neuropsychological assessments which included the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating—Sum of Boxes (CDR-SOB), and Global Deterioration Scale (GDS). Voxel-wise differences in regional cerebral blood flow were compared between the two groups.Results: Neuropsychological test results indicated cognitive impairment in all patients. SPECT analysis revealed multifocal hypoperfusion predominantly in the frontal, insular, and posterior cingulate regions in neurosyphilis patients compared with healthy controls (family-wise error corrected p &lt; 0.05).Conclusions: Together with previous findings, our results suggest that the hypoperfusion in the frontal, insular, and posterior cingulate regions may reflect cognitive impairments observed in neurosyphilis patients. Further studies with larger samples are needed to confirm our findings.
Information Complexity and Behavior Intention to Prescribe Antibiotics Based on the Antimicrobial Susceptibility Testing Report: The Mediating Roles of Information Overload and Attitude
Authors: Wang Ying , Zhang Xinping , Zhou Qian , Xu Xiaojun , Liu Xiaofeng , Lu Shaohui 
Published: November 2021

Background: The antimicrobial susceptibility testing (AST) report has guiding significance for physicians to prescribe antibiotics. This study aims to examine the effect of the AST report information complexity on physician’s intention to prescribe antibiotics based on the AST report, as well as the mediating role of information overload and attitude.Methods: A cross-sectional study conducted on 411 physicians in a general hospital in China in July 2021. Data were collected by a self-reported questionnaire. A serial multiple mediation model was tested to explore the sequential causality between the information complexity of the AST report, information overload, attitude, and behavior intention to prescribe antibiotics based on the AST report by using the SPSS macro PROCESS program.Results: Information complexity, information overload, attitude and behavior intention were significantly correlated (p &lt; 0.01). Information complexity can not only have a direct positive impact on the intention to prescribe antibiotics based on the AST report (effect = 0.173; SE = 0.044; Boot95%CI: LL = 0.089, UL = 0.260), but also have an indirect impact on behavior intention through the independent mediating role of information overload (effect = 0.025; SE = 0.011; Boot 95%CI: LL = 0.008, UL = 0.050) and the independent mediating role of attitude (effect = 0.130; SE = 0.025; Boot 95%CI: LL = 0.086, UL = 0.180), while the chain of information overload and attitude played a masking effect between information complexity and behavior intention (effect = −0.013; SE = 0.004; Boot 95%CI: LL = −0.023, UL = −0.005).Conclusion: The increase in information complexity can encourage physicians to prescribe antibiotics based on the AST report, information overload and attitude can promote this effect. It is necessary to provide physicians with sufficient information to prescribe antibiotics without increasing the burden on them. At the same time, publicity and standardized training should be conducted for physicians to interpret the AST report better and faster.
Relationship Between Cognitive and Clinical Insight at Different Durations of Untreated Attenuated Psychotic Symptoms in High-Risk Individuals
Authors: Xu LiHua , Zhang Mei , Wang ShuQin , Wei YanYan , Cui HuiRu , Qian ZhenYing , Wang YingChan , Tang XiaoChen , Hu YeGang , Tang YingYing , Zhang TianHong , Wang JiJun 
Published: November 2021

Background:This study examines whether cognitive insight is impaired in high-risk individuals with attenuated psychotic symptoms (APS) and explores the relationship between cognitive and clinical insight at different durations of untreated attenuated psychotic symptoms (DUAPS).Methods:The Structured Interview for Psychosis high-risk Syndrome (SIPS) was used to identify APS individuals. APS (n= 121) and healthy control (HC,n= 87) subjects were asked to complete the Beck Cognitive Insight Scale (BCIS). Clinical insight of APS individuals was evaluated using the Schedule for Assessment of Insight (SAI). APS individuals were classified into four subgroups based on DUAPS, including 0–3, 4–6, 7–12, and &gt;12 months. Power analysis for significant correlation was conducted using the WebPower package in R.Results:Compared with HC subjects, APS individuals showed poorer cognitive insight, with lower scores on BCIS self-reflectiveness and composite index (BCIS self-reflectiveness minus BCIS self-certainty). Only when DUAPS was longer than 12 months did the significant positive correlation between cognitive and clinical insight obtain the power about 0.8, including the associations between self-reflectiveness and awareness of illness, self-reflectiveness and the total clinical insight, and composite index and awareness of illness. The positive associations of composite index with awareness of illness within 0–3 months DUAPS and with the total score of SAI when DUAPS &gt; 12 months were significant but failed to obtain satisfactory power.Conclusions:APS individuals may have impaired cognitive insight, demonstrating lower self-reflectiveness. The correlation between cognitive and clinical insight is associated with the duration of untreated attenuated psychotic symptoms.
The Influence of Fermenting Yeast on the Sensory Properties of Graševina Wine
Authors: Deak Igor , Habschied Kristina , Mesić Josip , Babić Jurislav , Kovačević Dragan , Nedović Viktor , Mastanjević Krešimir 
Published: November 2021

Recent research has showed a breakthrough in investigating the effect of non-Saccharomyces yeast on wine quality and sensory properties. The aim of this study was to compare the influence of conventional yeast, Saccharomyces cerevisiae, vs. that of the non-Saccharomyces Torulaspora delbrueckii on the sensory profile of the white wine Graševina, and to establish if there are any differences in physical–chemical properties in regards to the applied yeast. Sample One was inoculated with both yeasts, while Sample Two was inoculated only with S. cerevisiae. The results indicated that a combination of T. delbrueckii and S. cerevisiae resulted in somewhat higher ethanol content in the finished wine. Sensory evaluation showed no significant discrepancies for any of the wines. Aspect and flavor were graded similarly, but the quality and intensity of the bouquet of Sample One was graded somewhat higher (14 and 6.6) than Sample Two (13.6 and 6.4). These findings open a very wide gate for future research in white wines.
Lung and Gut Microbiota Changes Associated with Pseudomonas aeruginosa Infection in Mouse Models of Cystic Fibrosis
Authors: Bacci Giovanni , Rossi Alice , Armanini Federica , Cangioli Lisa , De Fino Ida , Segata Nicola , Mengoni Alessio , Bragonzi Alessandra , Bevivino Annamaria 
Published: November 2021

Cystic fibrosis (CF) disease leads to altered lung and gut microbiomes compared to healthy subjects. The magnitude of this dysbiosis is influenced by organ-specific microenvironmental conditions at different stages of the disease. However, how this gut-lung dysbiosis is influenced by Pseudomonas aeruginosa chronic infection is unclear. To test the relationship between CFTR dysfunction and gut-lung microbiome under chronic infection, we established a model of P. aeruginosa infection in wild-type (WT) and gut-corrected CF mice. Using 16S ribosomal RNA gene, we compared lung, stool, and gut microbiota of C57Bl/6 Cftr tm1UNCTgN(FABPCFTR) or WT mice at the naïve state or infected with P. aeruginosa. P. aeruginosa infection influences murine health significantly changing body weight both in CF and WT mice. Both stool and gut microbiota revealed significantly higher values of alpha diversity in WT mice than in CF mice, while lung microbiota showed similar values. Infection with P. aeruginosa did not changed the diversity of the stool and gut microbiota, while a drop of diversity of the lung microbiota was observed compared to non-infected mice. However, the taxonomic composition of gut microbiota was shown to be influenced by P. aeruginosa infection in CF mice but not in WT mice. This finding indicates that P. aeruginosa chronic infection has a major impact on microbiota diversity and composition in the lung. In the gut, CFTR genotype and P. aeruginosa infection affected the overall diversity and taxonomic microbiota composition, respectively. Overall, our results suggest a cross-talk between lung and gut microbiota in relation to P. aeruginosa chronic infection and CFTR mutation.