bluuebunny/crossref_metadata_2025_split huggingface dataset:
ETV6-NTRK3 is Associated With Trisomy 8 and Sensitive to TRK Inhibitor in Hematologic Malignancy: Case Report of a Refractory AML and Review of the Literature
Authors: Zhang Ling , Wen Lijun , Wang Zheng , Zeng Zhao , Xu Yi , Pan Jinlan , Xue Shengli , Chen Suning , Wu Depei , Yang Xiaofei , Sun Aining 
Published: January 2021

Abstract
Background: The ETV6-NTRK3 fusion transcript has been found to recurrently identified in both solid tumors and leukemias. It has attracted a lot of interest for the clinical targeted therapy and genetic features in ETV6-NTRK3 positive solid tumors. While the t(12;15)(p13;q25)/ETV6-NTRK3 is a rare genetic aberration in hematologic malignancies at a low frequency of ≤1%. An accumulation of reported cases would be needed to discuss clinical and cytogenetic characteristics of the important entity. Therefore, it is useful to report every case for clinical implication of prognosis or therapy. Case presentation: We report the case of a previously healthy 30-year-old female, who was diagnosed as acute myeloid leukemia (AML) and presented with chemoresistance and short survival. The patient was treated with four cycles of chemotherapy but failed to achieve remission. Then the patient underwent a salvage haploidentical stem cell transplantation. Unfortunately, she worsened within 1 month and died of the refractory leukemia 35 days after transplantation. ETV6-NTRK3 rearrangement was revealed by RNA sequencing but the chromosomal translocation t(12;15)(p13;q25) was cryptic by conventional karyotype analysis. We review the literature and find that the ETV6-NTRK3 fusion transcript is associated with cryptic karyotype, trisomy 8, aggressive and poor prognosis in hematologic malignancy. The clinical and laboratory characteristics of ETV6-NTRK3 positive hematologic malignancies are different from those of solid tumors. Nevertheless, tropomyosin receptor kinase (TRK) inhibitor has powerful anti-tumor activity in patients with TRK fusion–driven cancers, regardless of the tumor type. Conclusions: We demonstrated that TRK inhibitor larotrectinib is an effective treatment on the primary bone marrow (BM) cells derived from the patient described here with ETV6-NTRK3 positive AML. Our report stresses the importance of screening for ETV6-NTRK3 fusion transcript in newly diagnosed leukemias and clinical treatment of TRK inhibitor in hematologic malignancies.
Electron Guiding in Macroscopic Borosilicate Capillaries With Large Bending Angles
Authors: Nguyen Hai-Dang , Wulfkühler Jan-Philipp , Heisig Jörg , Tajmar Martin 
Published: January 2021

Abstract
This work presents experiments about the transmission of electrons with an energy of around 15 keV with beam currents up to 20 µA through macroscopic glass capillaries. A systematic study was conducted to experimentally investigate the transmission of electrons through borosilicate glass capillaries with curve angles of 90°, 180°, 270° and 360° for the first time. The focus of the work was to identify the conditions under which the injected electron current is transmitted through the capillary. It was also shown that the transmission process in the macroscopic capillaries can be optically observed by cathodoluminescence – the interaction of electrons with the capillary surface causes locally a blue glow. Different distinctive “glow states” were observed and are found to correlate with different states of electron transmission.
Distinguishing Adenocarcinomas From Granulomas in The CT Scan of The Chest: Performance Degradation Evaluation in The Automatic Segmentation Framework
Authors: Tavakoli Mahsa Bank , Orooji Mahdi , Teimouri Mehdi , Shahabifar Ramita 
Published: January 2021

Abstract
Objective: The most common histopathologic malignant and benign nod- ules are Adenocarcinoma and Granuloma, respectively, which have di_erent standards of care. In this paper, we propose an automatic framework for the diagnosis of the Adenocarcinomas and the Granulomas in the CT scans of the chest from a private dataset. We use the radiomic features of the nodules and the attached vessel tortuos- ity for the diagnosis. The private dataset includes 22 CTs for each nodule type, i.e., adenocarcinoma and granuloma. The dataset contains the CTs of the non-smoker pa- tients who are between 30 and 60 years old. To automatically segment the delineated nodule area and the attached vessels area, we apply a morphological-based approach. For distinguishing the malignancy of the segmented nodule, two texture features of the nodule, the curvature Mean and the number of the attached vessels are extracted. Results: We compare our framework with the state-of-the-art feature selec- tion methods for di_erentiating Adenocarcinomas from Granulomas. These methods employ only the shape features of the nodule, the texture features of the nodule, or the torsion features of the attached vessels along with the radiomic features of the nodule. The accuracy of our framework is improved by considering the four selected features.
The Impact of Greenfield Investment on Domestic Entrepreneurship
Authors: Ha Son Tung , Chu Tuan Vu , Nguyen Thi Tuyet Mai , Nguyen Thi Hoai Dung , Nguyen Thi Ngoc Anh 
Published: January 2021

Abstract
The FDI-entrepreneurship nexus has received growing attention over the last decade. However, the empirical findings on their relationship have been inconsistent at best. This study seeks to examine how the inflows of Greenfield investment influence entrepreneurship of the host country. Using panel data from 110 countries during the period 2001-2018, we find that growing level of Greenfield investment brings detrimental impact on the level of total and opportunity-driven entrepreneurial activities in the host countries while the impact on necessity-driven entrepreneurship have been mixed. The results regarding the impact of Greenfield investment on total entrepreneurial activities and opportunity-based entrepreneurial activities are robust across different econometric settings, different time span and different categories of control variables.
18F-FDG PETCT and 68Ga-DOTA PETCT Mismatch With in Vivo Histopathological Characterization of Low Grade Neuroendocrine Pancreatic Tumor
Authors: Queiroz Marcello Moro , Lopes Carlos Diego Holanda , Salgues Alessandra Corte Real , Barbosa Felipe de Galiza , Abe Emerson Shigueaki , Silveira Thales Parenti , Machado Marcel Cerqueira Cesar , Capareli Fernanda Cunha 
Published: January 2021

Abstract
BackgroundPancreatic neuroendocrine tumor (PNET) is a subgroup of neuroendocrine tumor (NET) that has unique biology and natural history. The histological classification has a major role in the management of this pathology, but in recent years Gallium 68 dotatate (68Ga-DOTA) scanning is at the center of a discussion about how these imaging technologies can modify clinical management of neuroendocrine tumors and how their results are correlated to Ki67 index.MethodWe hereby describe a case of a patient that investigated an unspecific stable pancreatic nodule suspected of high-grade NET after evaluation with 68Ga-DOTATOC positron emission tomography - computed tomography (PETCT) and 18F-Fluorodeoxyglucose (18F-FDG) PETCT. ResultsThe images corroborate the hypothesis of high-grade NET based on the standard uptake value (SUV) described in both image exams (16.4 in 18FDG PETCT and 9.2 in 68Ga-DOTATOC PETCT). After surgery, the histopathological analyses revealed a localized grade 2 well differentiated NET, Ki-67 of 4.7, evidencing a rare case of mismatch between the functional image and the in vivo characterization of the neoplasm.ConclusionFunctional imaging of neuroendocrine tumors with different modalities of PETCT is a well-described strategy for evaluating PNET and can dictate conducts in some cases. However, histopathological analysis is crucial to confirm the grade and prognosis related to this disease. Besides the rarity of this case, our patient presented a mismatch between imaging and histopathological analysis, with the former one allowing active surveillance based on a low-grade neuroendocrine tumor.
Different Dietary Protein Sources in Low-Protein Diets Induces Changes in Antioxidant Capacity, Immunity, Fecal Microbiota and Metabolites of Weaned Piglets
Authors: Zhang Lianhua , Piao Xiangshu 
Published: January 2021

Abstract
Background: The inclusion of high-quality proteins and the protein restriction are commonly used in swine production. Our study was conducted to evaluate the effects of hydrolyzed wheat protein (HWP), fermented soybean meal (FSBM), and enzyme-treated soybean meal (ESBM) in low-protein diets on antioxidant capacity, immunity, fecal microbiota and metabolites of weaned piglets.Methods: A total of 144 weaned piglets were randomly assigned to 3 dietary treatments with 6 replications of 8 piglets per pen. The experiment was divided into phase 1 ( days 0-14) and phase 2 (days 15-28). The dietary treatments contained 15.90% HWP, 15.80% FSBM, and 15.10% ESBM in phase 1, and 7.90% HWP, 7.80% FSBM, and 7.50% ESBM in phase 2, respectively.Results: The ADG of piglets in the ESBM group was higher (P < 0.05) than HWP and FSBM during days 1-28. Compared with HWP and FSBM, piglets in ESBM had higher (P < 0.05) serum levels of FRAP and SOD on days 14, as well as higher (P < 0.05) serum FRAP level on days 28. Piglets in ESBM had lower (P < 0.05) serum levels of DAO and IL-1β than HWP on day 28. ESBM significantly increased the abundance of Bacteroidetes, Oscillospiraceae and Christensenellaceae and decreased the Clostridiaceae abundance in the feces compared with HWP and FSBM. The PICRUSt analysis revealed that the number of gene tags involved in valine, leucine and isoleucine degradation and lysine degradation in ESBM were lower (P < 0.05) than HWP and FSBM. Piglets in ESBM had higher (P < 0.05) fecal butyrate content compared with FSBM, and ESBM tended to decrease (P = 0.076) fecal cadaverine level.Conclusions: Overall, ESBM had advantages over HWP and FSBM in improving antioxidant capacity, immunity, and fecal microbiota and metabolites of weaned piglets.
A New Geometry Definition and Generation Method For a Face Gear&nbsp;Meshed With a Spur Pinion
Authors: Peng Xianlong 
Published: January 2021

Abstract
The conventional tooth surface of a face gear is difficult to manufacture, and the cutter is not uniform even though the parameters of its mating pinion slightly change. Based on the analysis of the features of the tooth surface, a new developable ruled surface approach is proposed that defines the tooth flank of the face gear, for which the most important feature is that it could be generated by a straight-edged cutter. This study presents mathematical models of the cutter and the new tooth surface and the corresponding deviation, correction and generation method for this surface, which are investigated through numerical examples. The manufacturing process is simulated by VERICUT software, and the results demonstrate that even when the principle deviation is added to the machined deviation, the absolute deviation is on the microscale. The meshing and contact simulation shows that the new surface could obtain good meshing performance when the number of face gear teeth is greater than three times the number of pinion teeth. This research provides a new method for manufacturing face gears.
A Novel Circular RNA&nbsp;circTADA2A&nbsp;Promotes Proliferation And Metastasis Of Ovarian Cancer Through Sponging miR-203
Authors: Wang Aihong , Jin Canhui , Wang Ying , Yu Juanjuan , Wang Ruifang , Tian Xiaoyu 
Published: January 2021

Abstract
BackgroundCircular RNAs (circRNAs), a new type of non-coding RNA, have been demonstrated to play critical roles in the progression of various of malignant cancers. In the present study, we identified a circRNA termed as circTADA2A which was hypothesized that may be significantly up-regulated in OC tissues and cell lines.ResultsThe results revealed that ectopic expression of circTADA2A promoted the cell proliferation, migration, invasion and colony formation ability of OC cells. Constantly, silencing of circTADA2A inhibited those of OC cells. Furthermore, we identified that circTADA2A was able to target miR-203 in OC cell. MiR-203 was able to reverse the oncogenic effect of circTADA2A on proliferation, migration and metastasis of OC cells through targeting SMAD1.ConclusionsWe reported that circTADA2A served as a competing endogenous RNA (ceRNA) to sponge miR-203 and blocked its regulation of SMAD1. These findings provide insights into OC progression and also potential new targets for diagnose or treatment of OC.
Feasibility of a Birth-cohort In Pakistan: Evidence For Better Lives Study
Authors: Anwer Yasmeen , Abbasi Fahad , Dar Ariba , Hafeez Abdullah , Hafeez Assad , Sikander Siham 
Published: January 2021

Abstract
BackgroundEvidence for Better Lives Study (EBLS) is an endeavour to establish a global birth cohort with participants from resource poor settings across the globe. It aims to investigate mediators and moderators of child development and wellbeing; it envisages informing policy and practice change to promote child health and wellbeing globally. Pakistan is one of the resource poor settings taking part in this global birth cohort; we report the feasibility of establishing such a birth cohort in Pakistan.MethodFrom March 2019 to July 2019, 153 third trimester pregnant women were identified, using community health worker registers, and approached for baseline demographics and a number of maternal wellbeing, mental health, support related information and stress related biomarkers in a peri-urban area of Islamabad Capital Territory. From October 2019 to December 2019, we re-contacted and followed 121 between 8-24 weeks postnatal period. All interviews were done after consent and data was collected electronically. Results150 (98%) third trimester pregnant women consented and were interviewed, 111 (74%) provided bio-samples and 121 (80.6%) were followed up postnatally. Their mean age and years of schooling was 27.29 (5.18) and 7.77 (4.79) respectively. Majority (82.3%) of the participants were housewives. Nearly a tenth were first time mothers while 63% of women reported current pregnancy to have been unplanned. Overall wellbeing and mental health were reported to be poor (WHO-5 mean scores 49.41 (32.20) & PHQ-9 mean scores 8.23 (7.0)). About 22% of women reported four or more adverse childhood experiences; 12.2% reported intimate partner violence during their current pregnancy. During the postnatal follow up visits, 58% of the women reported breastfeeding their infants. ConclusionThe study demonstrated Pakistan site could identify, approach, interview and follow up women and children postnatally, with a high response rates for both the follow up visits and bio-samples. Thus, a larger scale pregnancy birth cohort study in Pakistan is feasible to conduct.
Allometric Equations For Ethiopian Acacia Species&nbsp;
Authors: Aneseyee Abreham Berta , Soromessa Teshome , Elias Eyasu , Feyisa Gudina Legese 
Published: January 2021

Abstract
Background: Allometric equations are used to estimate biomass and carbon stock of forest. In Ethiopia, despite the presence of large flora diversity, only a few site-specific allometric equations are developed so far. This study was conducted in the Omo-Gibe woodland of south-western Ethiopia to develop an allometric equation to estimate the Above-ground Biomass (AGB) of the four Acacia species (Acacia polyacantha, Acacia seyal, Acacia etbaica and Acacia tortilis). Fifty-four (54) acacia trees were sampled and measured within 35 temporarily established square plots. In each plot, dendrometric variables were measured to derive the models based on combinations of Diameter Breast Height (DBH), height, and wood density as predictor variables. Model performance was evaluated using goodness-of-fit statistics. The biomass was compared using four allometric biomass models that have been widely used in the tropics.Result: The model containing DBH alone was more accurate to estimate AGB compared to the use of multiple predictor variables. This study, therefore, substantiated the importance of site-specific allometric equations in estimating AGB of Acacia woodlands. This is because a site-specific allometric equation recognizes the environmental factors, vegetation types and management practices. Conclusion: The results of this study contribute to a better understanding of allometric equations and an accurate estimate of AGB of Acacia woodlands in Ethiopia and similar ecosystems elsewhere.
An Early Detection of Acute Compartment Syndrome in Fastened Zip-Tie Rat Model Using Dynamic Phosphorous-31 Magnetic Resonance Spectroscopy at 9.4 Tesla
Authors: Ohta Hiroki , Vo Nhat-Minh Van , Hata Junichi , Terawaki Koshiro , Shirakawa Takako , Okano Hirotaka James 
Published: January 2021

Abstract
IntroductionAcute compartment syndrome (ACS) leads to a series of health problems, limb salvage, disability, and even death. In vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) provides a unique non-invasive method to assess skeletal muscle metabolisms such as inorganic phosphate (Pi), phosphocreatine (PCr), and adenosine triphosphate (ATP). The study aims to assess the ability of dynamic 31P-MRS in the early detection of muscular damage in ACS.Materials & MethodsThe study induced the fastened zip-tie model of ACS on normotensive Sprague-Dawley rats (n = 6). The spectra were acquired in Bruker 9.4-Tesla preclinical scanner using 1H/31P surface coil. 31P-MRS spectra and blood samples were obtained at time 0 (pre-ischemic phase) and every 15 minutes during the compression (120 minutes) and the reperfusion phase (90 minutes). 31P-MRS spectra findings were compared with plasma creatine phosphokinase (CPK).ResultsPCr/(Pi + PCr) ratio significantly decreased after muscle was compressed (P < 0.05). In contrast to this, CPK did not change significantly (P > 0.05). Both intracellular pH and arterial pH decreased over time. However, intracellular declined significantly (P < 0.05) at 60 minutes of ischemic state, and at 5 minutes and 60 minutes of reperfusion, while arterial pH slightly changed. After 30 minutes of ischemic, phosphomonoesters (PME) peak was detected, which was not seen at the pre-ischemic phase. It gradually increased and reached its highest peak at 120 minutes. At reperfusion state, 31P-MRS spectra and pH did not fully recover to their pre-ischemic state, and PME peak disappeared. There was a correlation between T2-weighted images and CPK from blood tests (R2 = 0.1996, P < 0.05).ConclusionsDynamic 31P-MRS technique is more clearly and rapidly detect the bioenergetic and mitochondrial functions change than blood test in a fastened zip-tie rat model of ACS. This technique is a promising non-invasive method to detect the early ischemic muscular damage in ACS.
Flue Vaccination does not Protect Against COVID-19 Infection; A Cross-Sectional Study.
Authors: Abbasi Mohammad Hossein , Rimaz Shahnaz , Esmaeili Sara , Faiz Seyed Hamid Reza , Riahi Taghi , Ansarin Melika , Aghakhani Kamran 
Published: January 2021

Abstract
Introduction: Vaccination is likely to be the final solution to stop the COVID-19 pandemic which has been considered as a global public health emergency. Influenza and corona viruses have previously demonstrated antigenic cross-reactivity.Methods:This cross-sectional study was aimed to evaluate the transmission rate and the severity of corona virus infection among health care workers with history of previous influenza vaccination. Subjects of the study were asked about their demographics, influenza vaccination history prior to pandemic, infection with Covid-19 and the severity parameters of the disease.Results:Influenza vaccination has no correlation in the prevalence ofCovid-19 infection rate nor in the severity of the disease process among those who received flu vaccines and those who were not vaccinated. Vaccinated and unvaccinated subjects were equal in terms of sex, age and comorbidities.Asthma has not demonstrated to contribute to the severity of the disease. Conclusion:Influenza vaccination, regardless of the evidence on its antigenic cross reactivity with corona virus, is not associated with lesser involvement by or any contribution to the severity of the 2019 novel SARS-COV2 disease.
Ferritin and LDH as Predictors of Mortality in COVID-19 Infection, Bosnia and Herzegovina Single-center Study
Authors: Jusufovic Vahid , Umihanic Sekib , Alibegovic Ervin , Piljic Dilista , Mujkanovic Amer , Bijedic Asja , Tulumovic Emir , Stratton Richard 
Published: January 2021

Abstract
Background Since the beginning of the COVID-19 pandemic, several inflammatory markers have been investigated as possible predictors of survival. Ferritin and from recently LDH have emerged as a possible marker that could serve to this purpose, with different cut-off levels than standard. Furthermore, serum elevations of these markers were reported in other viral infections such as dengue fever; while it has not been reported in MERS and SARS outbreaks and possibly making a biochemical distinction between COVID-19 and other similar diseases. The aim of this research was to establish independent admission levels of ferritin and LDH that predict lethal outcome more accurately. Methods In this prospective cohort study all the patients were hospitalized at UKC, B&H (n=137), between 28th of March and 1st of August 2020. The criteria for hospitalization was based on MEWS score, and all the inflammatory markers were evaluated in the first 72 hours of admission. Cut-off values of serum ferritin levels were set at 1500 ng/mL and LDH 350 U/L. Results Patients with serum ferritin levels >1500 ng/mL had 7.304 OR (CI95% 1.956-27.277; p=0.003) higher for lethal outcome than the group with <1500 ng/mL. Also, patients with levels of LDH >350 U/I had 5.560 (CI95% 2.480-12.468; p<0.001) higher OR of lethal outcome than patients with LDH <350 U/L. With the significant statistical difference between group means for both ferritin and LDH (p<0.001).Discussion Serum levels of ferritin >1500 ng/ml and LDH >350 U/L increase OR of lethal outcome. The levels of these inflammatory markers indicate the degree of inflammatory response and severity of the disaese as well as the possible outcome of the disease. Together these two markers could be used as predictors in clinical settings and treatment planning of patients with COVID-19.Conclusion: Together these two markers could be used as predictors in clinical settings and treatment planning of patients with COVID-19.