bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Website Sistem Informasi Transaksi Tagihan Layanan Purna Jual Properti Pada Pollux Properti Indonesia
Authors: Wicaksono Bagus Dwi , Anggraeni Sita 
Published: March 2021

Pollux Properti Indonesia merupakan pengembang proyek properti, termasuk pengembang, investasi, perdagangan, dan jasap enyewaan properti. Sistem penagihan yang ada masih dilakukan secara manual, yaitudengan sms dan telepon secara manual. Hal in imembutuhkan sumberdaya yang banyak dan kurang efisien dalam waktu, disamping pembayaran tagihan masih menggunakan satu fix virtual account sehingga kurang fleksibel bagi pelanggan untuk melakukan pembayaran. Pada penelitian ini, menghasilkan aplikasi berbasis web sistem informasi transaksi tagihan layanan purna jual, dengan menggunakan framework laravel. Metode yang digunakan dalam mengembangkan software adalah waterfall, dimana metode ini dimulai dari analisa kebutuhan, desain sistem dan software, coding, testing, dan implementasi. Hasil dari penelitian ini ialah dengan diimplementasikannya aplikasi sistem yang telah dibuat pada PT. Pollux Properti Indonesia, sebagai sarana penagihan dan pembayaran yang berjalan secara otomatis, serta memudahkan pengembang untuk menagih, pembayaran, serta melakukan pemeriksaan pembayaran yang masuk. Serta memudahkan pelanggan dalam membayar tagihan dan memeriksa riwayat transaksi yang telah dilakukan.
Perancangan Sistem Pendaftaran Siswa Baru Secara Online Pada SMK Miftahul Jannah Cikupa
Authors: Rahayu Sri , Setiadi Ade , Muryanto Alim 
Published: March 2021

Virus korona (COVID-19) belakangan ini menggegerkan seluruh dunia, tak terkecuali indonesia. bahkan indonesia termasuk kedalam 30 negara dengan penyebaran virus terbanyak di dunia. Pesatnya penyebaran virus korona (COVID-19) membaut institut pendidikan berhenti memberlakukan pembelajaran secara tatap muka, sehingga para siswa harus belajar secara daring dirumah masing-masing. Pada tahun ajaran baru para siswa yang telah lulus di sekolah sebelumnya harus memilih sekolah yang akan dituju selanjutnya. akan tetapi banyak sekolahan yang masih belum siap untuk mengatasi penumpukan calon siswa baru dan masih belum sepenuhnya menerapkan protokol keseharan COVID-19. Maka dari itu diciptakanlah sebuah perancarang sistem pendaftaran siswa didik baru secara online pada SMK Miftahul Jannah Cikupa untuk menghindari kontak fisik dan menumpuknya calon siswa baru pada lokasi sekolahan. Pada penelitian ini penulis menggunakan beberapa metodologi penelitian yaitu metode pengumpulan data diantaranya observasi, wawancara, dan studi pustaka, metode analisa menggunakan analisa SWOT, metode perancagan sistem menggunakan prototype, dan metode testing menggunakan blackbox testing. Hasil yang didapat pada penelitian ini yaitu calon siswa baru tidak perlu datang secara langsung ke sekolahan, cukup mengaksesnya lewat smartphone atau laptop dirumah masing-masing untuk melakukan pendaftaran secara online dan mengisi formulir yang telah tersedia di website, serta upload file-file yang di perlukan.

Kata kunci : Sistem, Pendafaratan Online, COVID-19
Video Profile Balai Latihan Kerja Pada Dinas Ketenagakerjaan Kota Tangerang
Authors: Sunarya Lusyani , Abdurachman Bisma , Ningsih Putri Rahayu 
Published: March 2021

ABSTRAK
Teknologi sekarang membuat dunia kerja seperti perusahaan, instansi lainnya mencari sumber daya manusia yang baru dan berkualitas dalam dunia kerja. Dinas Ketenagakerjaan membantu para pekerja yang baru lulus ataupun yang ingin mempunyai skill dengan melalui pelatihan yang diselenggarakan oleh Disnaker Kota Tangerang yang terletak di jalan Perintis Kemerdekaan II No.1, Cikokol, Babakan, Tangerang, Kec. Tangerang, Kota Tangerang, Banten. Permasalahan yang dihadapi Balai Latihan Kerja yaitu, kurangnya media dalam penyampaian informasi, seminar pelatihan yang diberikan BLK, sehingga perlunya media yang dapat menyampaikan informasi secara interaktif dan menarik. Tujuan dari penelitian ini menciptakan SDM para pekerja yang siap bersaing atau siap terjun di dunia kerja. Manfaat yang bisa masyarakat Kota Tangerang rasakan yaitu mudahnya mendapatkan informasi profile Disnaker, Balai Latihan Kerja sebagai tempat pelatihan. Metode penelitiannya yaitu: pengumpulan data, analisis SWOT, Perancangan Media dan konsep produksi media yaitu: pre production, production, dan postproduction. Hasil penelitian ini berupa media video profile yang diharapkan dapat membantu sebagai penunjang informasi Disnaker Kota Tangerang dan meningkatkan kemampuan Sumber Daya Manusia Kota Tangerang.
Kata Kunci - Video Profile, Sumber Daya Manusia
Joubert Syndrome: Reports of Two Cases
Authors: Kundu Gopen Kumar , Paul Bikush Chandra , Poddar Krishna Mohon 
Published: March 2021

Joubert syndrome related disorder(JSRD) is an autosomal recessive disorder characterized by hypotonia, abnormal eye movement,ataxia and breathing disturbance. The hall mark of the disease isthe presence of molar tooth malformationin magnetic resonance imaging (MRI) of brain. Diagnosis ofJSRD is based on clinical and neuro-radiological findings. Early and accurate diagnosis can help in planning the early intervention measures to reduce morbidity. Here, we report two cases. The first case, a 15 month old female baby, presented with hypotonia, polydactyly and seizure with molar tooth sign (MTS) in the MRI of brain.The second case, a three and a half-year-old child presented with developmental delay, hypotonia, abnormal eye movement, seizure and classical MTS in MRI of brain.
J Bangladesh Coll Phys Surg 2021; 39(2): 132-136
Prospects of using ultrasound therapy in combination with preparation possessing antiseptic effect in complex treatment of periodontitis
Authors: Volkov A. G. , Paramonova I. A. , Kopetskiy I. S. , Nikolskaya I. A. , Eremin D. A. , Kabisova G. S. , Mikhajlova E. G. , Pobozhieva L. V. 
Published: March 2021

Ultrasound is able to have a multifaceted therapeutic effect in periodontitis. In therapeutic doses, it affects a variety of local tissue reactions, stimulates compensatory, restorative, protective and adaptive mechanisms.Ultrasound in dosages used in clinical practice does not have an independent, direct antibacterial effect. In this regard, in the treatment of periodontitis, where the microbial factor plays an important role, it is advisable to use antiseptic solutions as a contact medium for ultrasonic effects. The study of the comparative effectiveness of low-frequency and high-frequency ultrasonic effects in combination with the domestic antiseptic preparation miramistin, which, with high antibacterial effectiveness, is characterized by the absence of adverse side effects, in the treatment of periodontitis, is of significant scientific and practical importance.
3. Constrained Freedom
Authors: Fredrikzon Johan 
Published: March 2021

Johan Fredrikzon spent one and a half years as a visiting research assistant at the Film and Media Studies Program at Yale University 2018/2019. Some months before he arrived, a two-day workshop on Simondon was held by the Yale-Düsseldorf Working Group on Philosophy and Media, titled Modes of Technical Objects, with scholars from the US and Germany. Fredrikzon decided to engage a few of the workshop participants for this special issue of Sensorium, with the purpose to discuss perspectives on Simondon as a theoretical instrument for thinking technology, how the French philosopher matters in their work, and why there seems to be a revival in the interest in the writing of Simondon these days. On behalf of the Sensorium journal, the interviewer would like to thank the three interviewees for their generous participation.
About Paul North:
Paul North is Professor at the Department of Germanic Languages & Literatures at Yale University. He teaches on media and literature from Ancient Greece through the romantic and enlightenment traditions into 20th century literary and critical theory. In The Yield: Kafka’s Atheological Reformation (Stanford, 2015) North presented a largely unknown Kafka based on readings of the famous writer’s theoretical works at the end of World War I. Paul North’s new book, Bizarre Privileged Items in the Universe: The Logic of Likeness (Zone Books, 2021) diverges from centuries of thought focused on the idea of difference to engage deeply with the concept of likeness: in evolution, in natural and social worlds, in language and in art. More on: paulnorth.org.
SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells
Authors: Wang Lude , Hu Bin , Pan Kailing , Chang Jie , Zhao Xiaoya , Chen Lin , Lin Haiping , Wang Jing , Zhou Gezhi , Xu Wenxia , Yuan Jianlie 
Published: March 2021

Methionine is one of the essential amino acids. How tumor cells adapt and adjust their signal transduction networks to avoid apoptosis in a methionine-restricted environment is worthy of further exploration. In this study, we investigated the molecular mechanism of glioma response to methionine restriction, providing a theoretical basis for new treatment strategies for glioma.MethodsWe constructed methionine-restriction-tolerant cells in order to study the response of glioma to a methionine-restricted environment. The transcriptome analysis of the tolerant cells showed significant changes in MAT2A. Western blotting, immunohistochemistry, quantitative real-time PCR, colony formation assays, and other experiments were used to verify the role of MAT2A in glioma genesis. In addition, the regulatory mechanism of MAT2A mRNA nuclear export was investigated by transfection, plasma nucleation separation, and co-immunoprecipitation.ResultsUnder methionine restriction, glioma cells showed high expression of MAT2A, and an inhibitor of MAT2A reduced the proliferation of tumor cells. The expression of MAT2A was positively correlated with World Health Organization-grade glioma. High expression of MAT2A was related to increased transfer of its mRNA out of the nucleus. The expression of nuclear export regulatory molecule MTR4 could affect the export of MAT2A mRNA. In a methionine-restricted environment, ubiquitination of MTR4 was enhanced, and thus its protein level was reduced. The E3 ubiquitin ligase was verified to be SYVN1.ConclusionIn summary, methionine restriction leads to increased ubiquitination of MTR4, which promotes the transfer of MAT2A mRNA out of the nucleus and MAT2A protein expression. MAT2A promotes histone methylation, prompting cells to proliferate in a methionine-restricted environment.
Intermuscular Fat Content in Young Chinese Men With Newly Diagnosed Type 2 Diabetes: Based on MR mDIXON-Quant Quantitative Technique
Authors: Yu Fuyao , He Bing , Chen Li , Wang Fengzhe , Zhu Haidong , Dong Yanbin , Pan Shinong 
Published: March 2021

ObjectiveSkeletal muscle fat content is one of the important contributors to insulin resistance (IR), but its diagnostic value remains unknown, especially in the Chinese population. Therefore, we aimed to analyze differences in skeletal muscle fat content and various functional MRI parameters between diabetic patients and control subjects to evaluate the early indicators of diabetes. In addition, we aimed to investigate the associations among skeletal muscle fat content, magnetic resonance parameters of skeletal muscle function and IR in type 2 diabetic patients and control subjects.MethodsWe enrolled 12 patients (age:29-38 years, BMI: 25-28 kg/m2) who were newly diagnosed with type 2 diabetes (intravenous plasma glucose concentration≥11.1mmol/l or fasting blood glucose concentration≥7.0mmol/l) together with 12 control subjects as the control group (age: 26-33 years, BMI: 21-28 kg/m2). Fasting blood samples were collected for the measurement of glucose, insulin, 2-hour postprandial blood glucose (PBG2h), and glycated hemoglobin (HbAlc). The magnetic resonance scan of the lower extremity and abdomen was performed, which can evaluate visceral fat content as well as skeletal muscle metabolism and function through transverse relaxation times (T2), fraction anisotropy (FA) and apparent diffusion coefficient (ADC) values.ResultsWe found a significant difference in intermuscular fat (IMAT) between the diabetes group and the control group (p&lt;0.05), the ratio of IMAT in thigh muscles of diabetes group was higher than that of control group. In the entire cohort, IMAT was positively correlated with HOMA-IR, HbAlc, T2, and FA, and the T2 value was correlated with HOMA-IR, PBG2h and HbAlc (p&lt;0.05). There were also significant differences in T2 and FA values between the diabetes group and the control group (p&lt;0.05). According to the ROC, assuming 8.85% of IMAT as the cutoff value, the sensitivity and specificity of IMAT were 100% and 83.3%, respectively. Assuming 39.25ms as the cutoff value, the sensitivity and specificity of T2 value were 66.7% and 91.7%, respectively. All the statistical analyses were adjusted for age, BMI and visceral fat content.ConclusionDeposition of IMAT in skeletal muscles seems to be an important determinant for IR in type 2 diabetes. The skeletal muscle IMAT value greater than 8.85% and the T2 value greater than 39.25ms are suggestive of IR.
Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes
Authors: Ramanjaneya Manjunath , Butler Alexandra E. , Alkasem Meis , Bashir Mohammed , Jerobin Jayakumar , Godwin Angela , Moin Abu Saleh Md , Ahmed Lina , Elrayess Mohamed A. , Hunt Steven C. , Atkin Stephen L. , Abou-Samra Abdul-Badi 
Published: March 2021

IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4. Elevated C3 levels have been associated with preeclampsia and the development of macrosomia.MethodsThis case-control study included 34 pregnant women with GDM and 16 non-diabetic (ND) women in their second trimester. Complement-related proteins were measured and correlated with demographic, biochemical, and pregnancy outcome data.ResultsGDM women were older with a higher BMI (p&lt;0.001); complement C3, C4 and Factor-H were significantly elevated (p=0.001, p=0.05, p=0.01, respectively). When adjusted for age and BMI, Complement C3 (p=0.04) and Factor-H (p=0.04) remained significant. Partial correlation showed significant correlation between C4 with serum alanine aminotransferase (ALT) (p&lt;0.05) and 2nd term diastolic blood pressure (p&lt;0.05); Factor-H and C-reactive protein (CRP; p&lt;0.05). Pearson bivariate analysis revealed significant correlations between C3, C4, and Factor-H and CRP; p&lt;0.05; C3 and gestational age at delivery (GA; p&lt;0.05); C4 and ALT and second-trimester systolic blood pressure (STBP) (p=0.008 and p&lt;0.05, respectively); Factor-H and glycated hemoglobin (HbA1c) (p&lt;0.05). Regression analysis showed that the elevation of C3 could be accounted for by age, BMI, GA and CRP, with CRP being the most important predictor (p=0.02). C4 elevation could be accounted for by ALT, CRP and STBP. CRP predicted Factor-H elevation.ConclusionThe increased C3, C4 and Factor-H during the second trimester of pregnancy in GDM are not independently associated with GDM; inflammation and high BMI may be responsible for their elevation. The elevation of second trimester C3 in GDM is associated with earlier delivery and further work is needed to determine if this is predictive.
Toxicity Profile of Combining PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy in Non-Small Cell Lung Cancer: A Systematic Review
Authors: Li Butuo , Jiang Chao , Pang Linlin , Zou Bing , Ding Mingjun , Sun Xindong , Yu Jinming , Wang Linlin 
Published: March 2021

BackgroundThe combination of immune checkpoint inhibitors (ICIs) and thoracic radiotherapy (TRT) has shown significant clinical activity in patients with non-small cell lung cancer (NSCLC). However, the currently available data on adverse events (AEs) were derived from a small subset of patients included in prospective clinical trials or retrospective studies. Thus, we conducted this systematic review to determine the AEs associated with this combination treatment.MethodsAn electronic literature search was performed in databases and conference proceedings of prospective clinical trials assessing the combination of ICIs and TRT for patients with NSCLC. The systematic analysis was conducted to determine the profile and incidence of AEs of combination treatment. We further performed the comparison of AEs between programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors, and sequential and concurrent administration of ICIs and TRT to help identify high risk patients. The systematic analyses were conducted with the Review Manager (version 5.3; The Cochrane Collaboration, Oxford, United Kingdom) and Stata version 12.0 (StataCorp, College Station, TX, USA) software.ResultsEleven clinical trials involving 1,113 patients with NSCLC were eligible for analysis. The incidence of all-grade AEs was 95.5%; that of high-grade AEs (grade ≥3) was 30.2%. The most frequent all-grade AE was fatigue (49.7%), while pneumonitis was the most common high-grade AE (3.8%) and grade 5 AE (0.6%). Notably, the toxicity profiles of PD-1 and PD-L1 inhibitors were similar. Concurrent treatment was associated with a higher incidence of higher-grade AEs (41.6% vs 24.8%, P=0.17) and pneumonitis (7.1% vs 3.9%, P=0.14) compared to sequential treatment, but no significant difference was observed.ConclusionMost AEs of this combination treatment are tolerable; as the most common high-grade AE, pneumonitis deserves the utmost attention of physicians. The toxicity profiles of patients receiving PD-1 or PD-L1 were similar, and no significant difference was observed between concurrent and sequential treatment.
Study of Microwave-Assisted MoS2 and Graphene Composite Counter Electrode for Dye-Sensitized Solar Cells
Authors: Yi Ling , Sun Hengchao , Yang Wen , Chen Weina , Luo Jian , Wang Jinyan , Kang Xing , Luo Detian , Ma Bing , Wang Yanjun , Su Songyong , Wang Zheng 
Published: March 2021

Graphene-MoS2 composites were synthesized via one-step microwave-assisted chemical bath deposition and used as counter electrodes for dye-sensitized solar cells, instead of traditional Pt film which has high cost and poor stability. The effects of graphene additive amount on the performance of cells were studied. The results reveal that sheet porous structure graphene and MoS2 particles has been incorporated tightly, which is the benefit of electrical conductivity and catalysis ability. A maximum efficiency of 6.3% has been achieved under 100 mW cm−2 illumination when the Mo:C is 1:1.
Rac3 Expression and its Clinicopathological Significance in Patients With Bladder Cancer
Authors: Chen Mei , Nie Zhenyu , Cao Hui , Gao Yuanhui , Wen Xiaohong , Zhang Chong , Zhang Shufang 
Published: March 2021

Background: Ras-related C3 botulinum toxin substrate 3 (Rac3) is overexpressed in malignancies and promotes tumor progression. However, the correlations between Rac3 expression and the clinicopathological characteristics and prognoses of patients with bladder cancer (BC) remain unclear.Methods: Data from The Cancer Genome Atlas (TCGA) were used to analyze Rac3 expression in BC and normal bladder tissues and validated using the Oncomine database, quantitative real-time PCR (qRT-PCR) and western blot. The Kaplan-Meier method was used to analyze the relationship between Rac3 expression and the prognosis of patients with BC. Cox univariate and multivariate analyses of BC patients overall survival (OS) were performed. Signaling pathways that potentially mediate Rac3 activity in BC were then analyzed by gene set enrichment analysis (GSEA).Results: The Rac3 expression in BC tissues was significantly higher than that in normal bladder tissues. Rac3 expression was significantly correlated with grade and stage. Overexpression of Rac3 was associated with a poor prognosis. GSEA showed that the cell cycle, DNA replication, p53 signaling pathway and mismatch repair were differentially enriched in the high Rac3 expression phenotype. The qRT-PCR and western blot results confirmed that the Rac3 expression in BC tissues was higher than that in normal bladder tissues.Conclusion: Rac3 is highly expressed in BC, which is related to the advanced clinicopathological variables and adverse prognosis of patients with BC. These results provide a new therapeutic target for BC.
Factors Associated with Survival From Xp11.2 Translocation Renal Cell Carcinoma Diagnosis—A Systematic Review and Pooled Analysis
Authors: Wu Yuqing , Chen Saisai , Zhang Minhao , Liu Kuangzheng , Jing Jibo , Pan Kehao , Zhang Lihua , Xu Bin , Lu Xiaoming , Chen Ming 
Published: March 2021

Purpose: Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) is a rare subtype of renal cell carcinoma (RCC), characterized by translocations of Xp11.2 breakpoints, involving of the transcription factor three gene (TFE3). The aim of our study was to comprehensively characterize the clinical characteristics and outcomes, and to identify risk factors associated with OS and PFS in Xp11.2 tRCC patients.Methods: Literature search on Xp11.2 tRCC was performed using databases such as pubmed EMBASE and Web of Science. Studies were eligible if outcomes data (OS and/or PFS) were reported for patients with a histopathologically confirmed Xp11.2 tRCC. PFS and OS were evaluated using the univariable and multivariable Cox regression model.Results: There were 80 eligible publications, contributing 415 patients. In multivariable analyses, the T stage at presentation was significantly associated with PFS (HR: 3.87; 95% CI: 1.70 to 8.84; p = 0.001). The median time of PFS was 72 months. In the multivariable analyses, age at diagnosis (HR: 2.16; 95% CI: 1.03 to 4.50; p = 0.041), T stage at presentation (HR: 4.44; 95% CI: 2.16 to 9.09; p &lt; 0.001) and metastasis status at presentation (HR: 2.67; 95% CI: 1.12 to 6.41; p = 0.027) were all associated with OS, with a median follow-up time of 198 months.Conclusion: T stage at presentation is the only factor that is associated with both PFS and OS in patients with Xp11.2 tRCC. Also, patients over 45 or with metastases are more likely to have poorer OS.
Pengaruh Perbandingan Massa Tanah dan Pupuk Kandang Ayam terhadap Pertumbuhan dan Hasil Tanaman Buncis Tegak (Phaseolus vulgaris L.)
Authors: Sitawati Rini , Nugraha Firman Satya , Khumairah Fiqriah Hanum , Widyastuti L Sri Nur 
Published: March 2021

Common bean (Phaseolus vulgaris L) is one type of vegetable crop favored by the Indonesian people. Its cultivation requires specific planting medium and rich in nutriens to meet plant growth and development need. This study aims to obtain the best ratio of soil mass and chicken manure fertilizer which can increase common bean growth and yield . This experiment was conducted from April 2019 to June 2019, in Langensari Village, Lembang District, West Bandung Regency with an altitude of 1,200 m above sea level. The experiment used Randomized Block Design (RBD)consisted of 5 treatments and repeated 5 times, namely A = 4.0 kg of soil: 0.0 kg chicken manure , B = 2.0 kg of soil: 2.0 kg chicken manure , C =1,3 kg of soil :2,7 kg chicken manure, D= 1,0 kg of soil : 3,0 kg chicken manure, and E = 2,7 kg of soil : 1,3 kg chiken manure per polibag. Results showed that the use of planting media with a soil media mass ratio of 2,0 kg of soil : 2,0 kg chiken manure increase plant height, number of leaves, number of fruits, fruit length and fruit weight compared the other treatmens, but the flowering and fruiting age of the plants were not different beetwen between treatments given.