bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of nomograms for predicting axillary non-SLN metastases in breast cancer patients with 1-2 positive sentinel lymph node macro-metastases: a retrospective analysis of two independent cohorts
Authors: Yu Yang , Wang Zhijun , Wei Zhongyin , Yu Bofan , Shen Peng , Yan Yuan , You Wei 
Published: May 2021

Abstract
Background

It is reported that appropriately 50% of early breast cancer patients with 1–2 positive sentinel lymph node (SLN) micro-metastases could not benefit from axillary lymph node dissection (ALND) or breast-conserving surgery with whole breast irradiation. However, whether patients with 1–2 positive SLN macro-metastases could benefit from ALND remains unknown. The aim of our study was to develop and validate nomograms for assessing axillary non-SLN metastases in patients with 1–2 positive SLN macro-metastases, using their pathological features alone or in combination with STMs.
Methods

We retrospectively reviewed pathological features and STMs of 1150 early breast cancer patients from two independent cohorts. Best subset regression was used for feature selection and signature building. The risk score of axillary non-SLN metastases was calculated for each patient as a linear combination of selected predictors that were weighted by their respective coefficients.
Results

The pathology-based nomogram possessed a strong discrimination ability for axillary non-SLN metastases, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.727 (95% CI: 0.682–0.771) in the primary cohort and 0.722 (95% CI: 0.653–0.792) in the validation cohort. The addition of CA 15 − 3 and CEA can significantly improve the performance of pathology-based nomogram in the primary cohort (AUC: 0.773 (0.732–0.815) vs. 0.727 (0.682–0.771), P < 0.001) and validation cohort (AUC: (0.777 (0.713–0.840) vs. 0.722 (0.653–0.792), P < 0.001). Decision curve analysis demonstrated that the nomograms were clinically useful.
Conclusion

The nomograms based on pathological features can be used to identify axillary non-SLN metastases in breast cancer patients with 1–2 positive SLN. In addition, the combination of STMs and pathological features can identify patients with patients with axillary non-SLN metastases more accurately than pathological characteristics alone.
Spirituality at Workplace: Role of Spiritual Leadership, Productivity, and Emotional Exhaustion
Authors: Abbas Ansar , Shuairidi Fendy , Ekowati Dian , Anwar Aisha , Saud Muhammad 
Published: May 2021

Abstract
Workplace spirituality understanding focuses upon employee’s inner life that nurtures the inner life irrespective of the gender of employees. It helps to encounter stress that brings emotional exhaustion in employee and affect productivity. This study looks at the role of spiritual leadership in promoting workplace spirituality, encountering emotional exhaustion, and cultivating productivity. In educational and healthcare workplace settings, systematic sampling was used to collect the data and processed in Wrap-pls for path analysis. It concludes that spiritual leadership research can provide unique insight, which has not been done persistently in South Asian countries. The study concludes positive results of spiritual leadership inculcating workplace spirituality to improve organizational engagement, efficiency, and life satisfaction. Finally, the pertinent sections discuss some recommendations for future leadership scopes, science, and practice in applied contexts.
Phenotype-guided subpopulation identification from single-cell sequencing data
Authors: Sun Duanchen , Guan Xiangnan , Moran Amy , Qian David , Schedin Pepper , Dai Mu-Shui , Danilov Alexey , Alumkal Joshi , Adey Andrew , Spellman Paul , Xia Zheng 
Published: May 2021

Abstract
Single-cell sequencing yields novel discoveries by distinguishing cell types, states, and lineages within the context of heterogeneous tissues. However, interpreting complex single-cell data from highly heterogeneous cell populations remains challenging. Currently, most existing single-cell data analyses focus on cell type clusters defined by unsupervised clustering methods that cannot directly link cell clusters with specific biological and clinical phenotypes. Here we present Scissor, a novel approach that utilizes disease phenotypes to identify cell subpopulations from single-cell data that are most highly associated with the given phenotype. This “phenotype-to-cell” within a single-step strategy utilizes clinical information collected from bulk assays to identify the most highly phenotype-associated cell subpopulations. When applied to a lung cancer single-cell RNA-seq (scRNA-seq) dataset, Scissor identified a subset of cells associated with worse survival as well as another cell subpopulation associated with TP53 mutation. Furthermore, in a melanoma scRNA-seq dataset, Scissor discerned a T cell subpopulation with low PDCD1/CTLA4 and high TCF7 expressions, which is associated with a favorable immunotherapy response. Scissor also demonstrated its broad applicability and effectiveness in interpreting Facioscapulohumeral muscular dystrophy (FSHD) and Alzheimer’s disease scRNA-seq datasets. Thus, Scissor provides a novel framework to identify biologically and clinically relevant cell subpopulations from single-cell assays by leveraging the wealth of phenotype and bulk-omics datasets.
The efficacy of amantadine hydrochloride in the treatment of COVID-19 - a single-center observation study
Authors: Bodnar Wlodzimierz , Aranda-Abreu Gonzalo , Slabon-Willand Monika , Kotecka Sylwia , Farnik Malgorzata , Bodnar Jaroslaw 
Published: May 2021

Abstract
Introduction: Coronavirus disease 19 (COVID-19) rapidly spread worldwide. The search for effective measures to counter the development and effects of the pandemic includes: identifying the disease pathogen, introducing methods of reducing its transmission, building the population immunity, and the search for a cure, both among the new and already-known substances with potential antivirus activity such as amantadine hydrochloride.Study objectives: The study's aim is an observational single-center analysis of confirmed COVID-19 cases treated with amantadine in ambulatory settings.Patients and methods: The group of 55 patients with confirmed COVID-19 diagnosis was treated in ambulatory settings by amantadine with a treatment schema. A retrospective analysis was based on symptoms, hospitalization, and number of deaths.Results: The mean age of the patients was 55.9 years (SD=15), and most patients were male (60%). Despite the majority of patients 64% (n=35) suffering from comorbidities and 53% (n=29) of patients having been diagnosed with pneumonia, none of them died, and only four had required hospitalization in the course of COVID-19. Clinical stabilization was achieved in 91% (n=50) of patients within 48 hours after the first dose of amantadine with further improvement; additionally, all patients experienced remission of COVID-19. In total, 93% (n=51) of patients did not require hospitalization during the treatment.Conclusions: The data may suggest that amantadine hydrochloride shows efficacy in preventing hospitalization and deaths in patients with COVID-19. At the same time, it emphasizes that daily monitoring of the patient and regular examination are important in the case of SARS-CoV-2 infection dynamics.
Methodological approach to mutually agreed corporate image management and economic security of enterprise
Authors: Rudenko Inna , Kolesnyk Alina , Bolotova Tetiana , Bogoyavlenskiy Oleg , Halkina Olha , Pustova Viktoriia , Darmostuk Denis 
Published: May 2021

The object of research: corporate image and enterprise economic security.
Investigated problem: methodical approach to mutually agreed management of enterprise’s image and its economic security.
The main scientific results: theoretical analysis of the opinions, which are presented in the scientific literature of enterprise economic security functional components and the mechanism of their formation, is carried out. The functional components of economic security related to the internal and external aspects of enterprise are studied in detail, and their close relationship with image components is determined. The stages of enterprise image management are schematically shown with taking into account the compliance of image economic security components levels.
The area of practical use of the research results: the need to adhere to certain sequence of actions aimed at forming a positive image and managing it in enterprises is emphasized. It is advisable to use an approach to the formation of corporate image with taking into account the targeted influence of management entities on the business environment.
Technological innovation: the enterprise economic security structure in the context of modern tendencies is proposed, the complex of measures which are recommended to be applied for enterprise image maintenance is determined.
Scope of application for technological innovation: practical activity of Ukrainian enterprises is in interconnection with other business environment participants.
The use of the topics and vocabulary of the Second World War in the Russian-Ukrainian conflict 2014-2020 (analysis of foreign historiography)
Authors: Semenenko Valeriy , Radchenko Liudmyla , Rudenko Svitlana , Kobzieva Iryna , Nikolaienko-Lomakina Alla , Rezenkina Nataliia 
Published: May 2021

The object of research is the latest English literature of scientists and analysts in Western Europe and America, devoted to the problems of the information war waged by the Kremlin authorities against Ukraine. It is the problems, events of the Second World War, in the Russian-speaking academic space and the media that are still referred to only as the Great Patriotic War that became the leitmotif of these actions. Moreover, the history of the war is used precisely speculatively, that is, a careful selection of facts and conclusions is carried out, which are adjusted to certain conceptual foundations.
Investigated problem. As a result of a critical analysis of the works of Western authors, the problem posed in this work is solved: to show the objectivity and evidence of the narratives of foreign authors on the biased presentation of the topics and vocabulary of World War II about the events in the East of Ukraine in 2014-2020.
Main scientific results. The main scientific result of the study is the conclusion that Western scientists are deeply immersed in the vicissitudes of the conflict, debunking the biased evidence of Russian experts, fascist tendencies are imposed on the basis of false accusations of Ukraine, although such processes have not been recorded by any foreign analysts and observers. One of the stereotypes of Russian propaganda is the reproach for the massive "banderization" of the consciousness of citizens, but at the same time the face and activities of the leader of the OUN (b) are deliberately distorted. Modern studios of historians, diplomats, analysts of Western Europe, the USA, Canada are convincingly criticizing the political and ideological measures of Moscow aimed at discrediting the Ukrainian people. It is emphasized that the process of "nationalization" of history in Ukraine, especially during the Second World War by the Russian establishment, was used in a fraudulent way to tarnish the past of Ukraine. It was noted that, despite all the efforts of the Russian information and propaganda machine, Moscow fails to achieve the desire for results.
Scope of practical application. The research results, which are innovative in nature, can be used in both cognitive and educational values.
A LU:−16 individual with antibodies
Authors: Éthier C. , Parent C. , Lemay A.-S. , Baillargeon N. , Laflamme G. , Lavoie J. , Perreault J. , St-Louis M. 
Published: May 2021

Abstract
Antibodies against Lutheran blood group antigens have been observed during first-time pregnancy. Samples from a woman of African descent were tested in our immunohematology laboratory on several occasions since 2001. Her samples were phenotyped as Lu(a+b−), and anti-Lub was suspected but not identified. She was asked to make autologous donations in preparation for her delivery, which she did. In 2010, two antibodies were identified: anti-Lea and -Lub. Six years later, a third investigation was requested. This time, an antibody directed at a high-prevalence Lutheran antigen was found in addition to the anti-Lea and -Lub previously observed. Her serum was compatible with three out of five Lu(a−b−) reagent red blood cells (RBCs). One of the incompatible Lu(a−b−) reagent RBCs was known to be In(Lu) (KLF1 mutation). The genetic background of the other reagent RBC was unknown. The LU cDNA sequence analysis revealed the presence of the c.230G>A (Lua), c.679C>T (LU:–16), and a silent polymorphism c.1227G>T. Anti-Lu16 was highly suspected. This would be the fifth case of LU:–16 with antibodies reported, all within women of African heritage with the Lu(a+b−) phenotype. Hemolytic disease of the fetus and newborn was not noted in these cases.
Immunohematology

2017;33:110–113.
Berbagi Kepemimpinan dan Pelayanan: Transformasi Peran Ketua Kelompok di Gereja Kristen Jawa Bekasi Timur
Authors: Kristantara Johan 
Published: May 2021

Abstract This article proposes a transformation of leadership in a congregation by transforming roles of cell leaders. The research departs from a concern that leadership in many churches—including Gereja Kristen Jawa (GKJ) Bekasi Timur—tends to be oriented and centralized toministerial offices (pastors, elders, and deacons). Consequently, the roles of lay leadership have not been given enough attention. This research employs an empirical-analytical approach—enquiring empirical perceptions of leadership in a congregation and analyzing them with church leadership concepts from Kevin G. Ford and E. Stanley Ott. The methods used in this research are qualitative field research (by conducting deep interviews) as well as literary research (using closelyrelated books and journal articles). The finding of this research suggests that shared leadership and ministry transforms centralized leadership(autocracy) culture, making possible various ministries to be carried out in more vital and effective ways.
Abstrak Artikel ini menawarkan transformasi kepemimpinan jemaat dengan mentransformasikan peran para ketua kelompok. Penelitian ini berangkat dari keprihatinan bahwa kepemimpinan di banyak gereja— termasuk di Gereja Kristen Jawa (GKJ) Bekasi Timur—cenderung berorientasi dan berpusat pada jabatan gerejawi (pendeta, penatua/tua-tua, dan diaken). Akibatnya, peran kepemimpinan warga jemaat biasa kurang mendapat perhatian. Artikel ini menggunakan metode empiris-analitis, yang menggali persepsi empiris kepemimpinan jemaat lalu menganalisisnya dengan konsep-konsep kepemimpinan gereja dari Kevin G. Ford dan E. Stanley Ott. Teknik yang dipakai dalam kajian ini adalah penelitian lapangan kualitatif (dengan melakukan wawancara mendalam) dan penelitian pustaka (menggunakan buku-buku dan artikel-artikel jurnal terkait). Temuan penelitian ini menunjukkan bahwa pendekatan berbagi kepemimpinan dan pelayanan memungkinkan kultur kepemimpinan yang sentralistik (otokrasi) ditransformasikan menjadi kultur desentralistik yang berbagi sehingga pelayanan-pelayanan akan berjalan secara lebih hidup dan efektif.
Perempuan dalam Injil dan dalam Teologi Moral
Authors: Mali Mateus 
Published: May 2021

Abstract Feminism is one of social-moral thoughts that challenge the hegemony of patriarchy. Feminists begin their struggle with critique of male domination and ask for valorization of women’s way of thinking, feeling, and moral decisions. According to feminists, one of the communities that are insensitive of feminist issues is the Catholic Church because the church lives in a patriarchal system. Methodology used in this article is hermeneutic. In the light of Jesus’ way, moral theology tries to reflect the problem of feminism and the role of woman in the Church. The main focus of this article is the analysis of feminism in the Gospel and in moral theology. The goal of this writing is to push Catholic women to participate more in the ecclesial life and to correct the male languages of theology to be more feminine-sensitive.
Abstrak Feminisme adalah salah satu pemikiran moral sosial yang menantang hegemoni patriarkal. Para penggerak perempuan menuntut penghargaan dari cara berpikir, berperasaan, dan mengambil keputusan moral dari para perempuan dan mengkritik dominasi laki-laki. Menurut penggerak feminisme, salah satu komunitas yang melanggengkan persoalan tentang perempuan adalah Gereja Katolik karena dia hidup dalam sistem patriarkal.Metodologi yang digunakan dalam artikel ini adalah hermeneutik. Dalam terang cara Yesus, teologi moral mencoba untuk merefleksikan persoalan perempuan dan peranannya di dalam Gereja. Fokus utama dari artikel ini adalah analisa tentang feminisme di dalam Injil dan dalam teologi moral. Tujuan penulisan ini adalah mendorong perempuan Katolik untuk lebih mengambil bagian dalam kehidupan menggereja dan untuk membetulkan bahasa teologi yang terlalu bersifat laki-laki menjadi bahasa teologi yang lebih bersifat perempuan.
Epicardial mapping and ablation for ventricular arrhythmias in experienced center without onsite cardiac surgery: A feasibility report
Authors: Chen Shaojie , Chun K R Julian , Bordignon Stefano , Tohoku Shota , Schmidt Boris 
Published: May 2021

Objective: Epicardial access is sometimes required to effectively treat ventricular arrhythmias, but it can be associated with increased risk of procedural complications needing surgical intervention. The present study aimed to evaluate the feasibility and safety of epicardial mapping/ablation in experienced center without onsite cardiac surgery.Methods: Patients who had drug-refractory, recurrent ventricular arrhythmias were scheduled for catheter ablation. All surgeons had at least fifty pericardial puncture experiences. Epicardial puncture and perioperative anticoagulation were carried out based on institutional protocol. Phrenic nerve was mapped by 3-D mapping system. Coronary anatomy was delineated by coronary angiography.Results: A total of 44 patients (63.3 years, male 86.4%) received epicardial access. Of them 7 (15.9%) were scheduled for PVC ablation, 37 (84.1%) for VT ablation (ICM: 25%, NICM: 59.1%). Mean LVEF was 41.3%. Acute ablation success rate was 35 (79.5%). Procedural adverse events included: pericardial effusion occurred in 3 (6.8%) patients who all well treated with pericardial drainage; and pericardial tamponade in 1 (2.3%) patient requiring transfer to surgical intervention. No death, stroke, phrenic nerves palsy, or coronary artery injury were observed. Median hospitalization was 4 (3-6) days. Univariable analysis and ROC curve showed that patients’ age was a significant predictor of epicardial procedural complication (area under curve (AUC): 0.813, P=0.041).Conclusions: Guided by a tailored procedural protocol, the majority of the epicardial access related complications can be treated conservatively without needing onsite surgery. Older age is a risk factor associated with epicardial access related complications.
Model Prediksi Persen Lemak Tubuh Remaja Putri: Studi Cross Sectional
Authors: Khairani Nurul , Sudiarti Trini 
Published: May 2021

The purpose of this study was to get the prediction model which had optimum validity for estimating body fat percentage of adolescent girls. The design of this study was a Cross Sectional. The sampels were 110 school girls which taken by Stratified Proportional technique. Anthropometric measurements consisted of measurements of age, weight, and height (to obtain the BMI (kg/ m2) and BMI (WHO Z Score)), waist circumference, and skinfold thickness. Body fat percentage was measured using various predictive models. Bivariate analysis used was the correlation test. Multivariate analysis used was multiple linear regression test. The ROC test was used for the validation test to determine the Area Under Curve (AUC) value, sensitivity, specificity, Positive Predictive Value (PVP), Negative Predictive Value (PVN), Likelihood Ratio + or (LR +), and LR-. The result of the study showed that the average of body fat percentage of samples was 26,51% ± 5,48%. The prediction model which obtained from multivariate analysis was BFP= 0,991 BMI +0,069 ST+0,249 A -1,703. Based on the validation test, the prediction model of this study had optimum validity in compared with other prediction models. Tujuan dari penelitian ini adalah untuk mendapatkan model prediksi yang memiliki validitas optimal untuk memperkirakan persen lemak tubuhremaja putri. Desain penelitian adalah Cross Sectional. Sampel yang diambil sebanyak 110 siswi dengan menggunakan teknik Stratifikasi Proporsi. Pengukuran antropometri terdiri dari pengukuran usia, berat badan dan tinggi badan (untuk mendapatkan nilai IMT (kg/m2) dan IMT WHO Z Score), lingkar pinggang, dan skinfold thickness. Persen lemak tubuh diukur dengan menggunakan berbagai model prediksi. Analisis bivariat menggunakan uji korelasi. Analisis multivariat menggunakan uji regresi linier ganda. Uji ROC digunakan untuk uji validasi untuk mengetahui nilai Area Under Curve (AUC), sensitivitas, spesifisitas, Predictive Value Positif (PVP), Predictive Value Negative (PVN), Likelihood Ratio + atau (LR+), dan LR-. Hasil penelitian menunjukkan bahwa rerata persen lemak tubuh responden adalah 26,51 % ± 5,48 %. Model prediksi yang didapatkan dari hasil multivariat adalah PLT= 0,991 IMT + 0,069 ST + 0,249 U -1,703. Berdasarkan hasil uji validasi, model prediksi tersebut memiliki validitas optimal jika dibandingkan dengan model prediksi lainnya.
Improving Management of Type 2 Diabetes Using Home-Based Telemonitoring: Cohort Study
Authors: Milani Richard , Chava Pavan , Wilt Jonathan , Entwisle Jonathan , Karam Susan , Burton Jeffrey , Blonde Lawrence 
Published: May 2021

Background
Diabetes is present in 10.5% of the US population and accounts for 14.3% of all office-based physician visits made by adults. Despite this established office-based approach, the disease and its adverse outcomes including glycemic control and clinical events tend to worsen over time. Available home technology now provides accurate, reliable data that can be transmitted directly to the electronic medical record.

Objective
This study aims to evaluate the impact of a virtual, home-based diabetes management program on clinical measures of diabetes control compared to usual care.

Methods
We evaluated glycemic control and other diabetes-related measures after 1 year in 763 patients with type 2 diabetes enrolled into a home-based digital medicine diabetes program and compared them to 794 patients matched for age, sex, race, BMI, hemoglobin A1c (HbA1c), creatinine, estimated glomerular filtration rate, and insulin use in a usual care group after 1 year. Digital medicine patients completed questionnaires online, received medication management and lifestyle recommendations from a clinical pharmacist or advanced practice provider and a health coach, and were asked to submit blood glucose readings using a commercially available Bluetooth-enabled glucose meter that transmitted data directly to the electronic medical record.

Results
After 1 year, usual care patients demonstrated no significant changes in HbA1c (mean 7.3, SE 1.7 to mean 7.3, SE 1.6; P=.41) or changes in the proportion of patients with HbA1c≥9.0 (n=117, 15% to n=113, 14%; P=.51). Digital medicine patients demonstrated improvements in HbA1c (mean 7.3, SE 1.5 to mean 6.9, SE 1.2; P<.001) and significant changes in the proportion of patients with HbA1c≥9.0 (n=107, 14% to n=49, 6%; P<.001), diabetes distress (n=198, 26% to n=122, 16%; P<.001), and hypoglycemic episodes (n=313, 41.1% to n=91, 11.9%; P<.001).

Conclusions
A digital diabetes program is associated with significant improvement in glycemic control and other diabetes measures. The use of a virtual health intervention using connected devices was widely accepted across a broad range of ethnic diversity, ages, and levels of health literacy.