bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Control for a Mathematical Model of Cancer Disease via Dynamic Programming Approach
Authors: Gueridi D. , Bouremani T. , Slimani Y. , Ghebouli M. A. , Fatmi M. , Metwally Ahmed Sayed M. 
Published: December 2024

ABSTRACTThe objective of this paper is to provide a comprehensive overview of optimal control models in the context of cancer treatment. We will explore how these mathematical models are used to optimize the administration of anticancer drugs. By understanding the principles behind optimal control models, we can appreciate their potential to revolutionize cancer treatment and contribute to personalized medicine. We utilize recent advancements in dynamic programming method to achieve a rigorous solution for a cancer disease model proposed by Neilan as an unsolved problem. Beginning with a certain refinement of Cauchy's method of characteristics for stratified Hamilton–Jacobi equations allows us to delineate a broad range of admissible trajectories. This, in turn, leads to the identification of a domain wherein the value function not only exists but is also generated by a certain admissible control. While the optimality is checked by using one of the well‐known verification theorems taken as sufficient optimality conditions.JEL Classification: 2000 MSC: 49J15, 49L20, 35F21
The Association Between Longitudinal Changes in Body Mass Index and Longitudinal Changes in Hours of Screen Time, and Hours of Physical Activity in German Children
Authors: Hoehne Sophie , Pollatos Olga , Warschburger Petra , Zimprich Daniel 
Published: December 2024

ABSTRACTIntroductionThe association of screen time and physical activity with body weight in children has been investigated in cross‐sectional and prospective studies, as well as randomized controlled trials. The present study extends previous research by examining how longitudinal within‐person changes in screen time and physical activity relate to changes in Body Mass Index (BMI) in children, and how changes in screen time and physical activity relate to each other.MethodsThe data for the present study came from the PIER Youth Study. Data were collected from 971 children and their parents at two time points approximately 1 year apart. A multilevel modeling approach with measurement occasions nested within children was used to model changes in BMI across age.ResultsWithin a child, a change in daily hours of TV viewing was associated with a corresponding change in BMI, whereas a change in daily hours of physical activity was associated with an opposite change in BMI. Within‐person correlations between changes in screen time and physical activity were small but positive.ConclusionThe present findings have important implications for interventions to reduce and prevent childhood overweight and obesity. Specifically, interventions should focus on both reducing daily TV viewing and promoting physical activity.
Enhancing Lot Sentencing Through a Capability Index‐Based Skip‐Lot Sampling Scheme
Authors: Liu Shih‐Wen , Wu Chien‐Wei , Wei I‐Ting 
Published: December 2024

ABSTRACTAn acceptance sampling plan (ASP) is a commonly used tool in quality assurance that allows business partners to make decisions about lot disposition. To enhance the efficiency and applicability of inspection, various ASPs have been constructed to meet different circumstances in practical applications. One of these ASPs is the skip‐lot sampling plan (SkSP), which reduces inspection time and cost for a series of product lots from a supplier with excellent quality records. Based on the structure of the SkSP, we propose an improved variables SkSP that uses a repetitive group sampling (RGS) plan based on the most commonly used capability index Cpk as the reference plan, designated as Cpk‐based SkSP‐RGS. This plan is optimized using a model that ensures the operating characteristic function meets a two‐point condition and minimizes the average sample number (ASN). Additionally, two main performance measures of sampling plans, ASN and discriminatory power, are investigated. The results reveal the superiority of the proposed plan over conventional Cpk‐based sampling plans. Lastly, a case study from the liquid crystal module industry is demonstrated using the proposed plan to show its applicability and practicality.
A Respiratory Signal Monitoring Method Based on Dual‐Pathway Deep Learning Networks in Image‐Guided Robotic‐Assisted Intervention System
Authors: Wang Xiaodong , Zhu Jianjun , Wang Yong , Wang Cheng , Chen Peng , Lyu Pengju , Xu Jun , Teng Gao‐Jun 
Published: December 2024

ABSTRACTBackgroundPercutaneous puncture procedures, guided by image‐guided robotic‐assisted intervention (IGRI) systems, are susceptible to disruptions in patients' respiratory rhythm due to factors such as pain and psychological distress.MethodsWe developed an IGRI system with a coded structured light camera and a binocular camera. Our system incorporates dual‐pathway deep learning networks, combining convolutional long short‐term memory (ConvLSTM) and point long short‐term memory (PointLSTM) modules for real‐time respiratory signal monitoring.ResultsOur in‐house dataset experiments demonstrate the superior performance of the proposed network in accuracy, precision, recall and F1 compared to separate use of PointLSTM and ConvLSTM for respiratory pattern classification.ConclusionIn our IGRI system, a respiratory signal monitoring module was constructed with a binocular camera and dual‐pathway deep learning networks. The integrated respiratory monitoring module provides a basis for the application of respiratory gating technology to IGRI systems and enhances surgical safety by security mechanisms.
Predictive Capacities of a Machine Learning Decision Tree Model Created to Analyse Feasibility of an Open or Robotic Kidney Transplant
Authors: Martinino Alessandro , Khanolkar Ojus , Koyuncu Erdem , Petrochenkov Egor , Bencini Giulia , Olazar Joanna , Di Cocco Pierpaolo , Almario‐Alvarez Jorge , Spaggiari Mario , Benedetti Enrico , Tzvetanov Ivo 
Published: December 2024

ABSTRACTBackgroundMachine learning has emerged as a potent tool in healthcare. A decision tree model was built to improve the decision‐making process when determining the optimal choice between an open or robotic surgical approach for kidney transplant.Methods822 patients (OKT) and 169 (RKT) underwent kidney transplantation at our centre during the study period. A decision tree model was built in a two‐step process consisting of: (1) Creating the model on the training data and (2) testing the predictive capabilities of the model using the test data.ResultsOur model correctly predicted an OKT in 148 patients out of 161 test cases who received an OKT (accuracy 91%) and predicted an RKT in 19 out of 25 test cases of patients receiving an RKT (accuracy 76%).ConclusionOur model represents the inaugural data‐driven model that furnishes concrete insights for the discernment between employing robotic and open surgery techniques.
Nonequilibrium Self‐Assembly of Microtubules Through Stepwise Sequential Interactions of DNA
Authors: Keya Jakia Jannat , Akter Mousumi , Yamasaki Yuta , Kageyama Yoshiyuki , Sada Kazuki , Kuzuya Akinori , Kakugo Akira 
Published: December 2024

AbstractThe assembly of biological systems forms nonequilibrium patterns with different functionalities through molecular‐level communication via stepwise sequential interaction and activation. The mimicking of this molecular signaling offers extensive opportunities to design self‐assemblies of bioinspired synthetic nonequilibrium systems to develop molecular robots with active, adaptive, and autonomous behavior. Herein, the design and construction of biomolecular motor system, microtubule (MT)‐kinesin based molecular swarm system, are reported through stepwise sequential interactions of DNA. DNA signals are exchanged between three different DNA‐tethered MTs, whereby the DNA signal from the first MT can activate the DNA strand on the second MT by communicating through physical contact, which facilitates assembly formation between the second and third DNA‐tethered MTs. The DNA strands on the MTs can recognize the specific sequences of other DNA strands in the system and communicate with the complementary DNA on other MTs. This work will pave the way for developing autonomous molecular machines with advanced functionalities for complex nanotechnological applications.
Macro‐ and Nano‐Porous Ag Electrodes Enable Selective and Stable Aqueous CO2 Reduction
Authors: Nourmohammadi Khiarak Behnam , da Silva Gelson T. S. T. , Grange Valentine , Gao Guorui , Golovanova Viktoria , de García de Arquer F. Pelayo , Mascaro Lucia H. , Dinh Cao‐Thang 
Published: December 2024

AbstractElectrochemical carbon dioxide (CO2) reduction from aqueous solutions offers a promising strategy to overcome flooding and salt precipitation in gas diffusion electrodes used in gas‐phase CO2 electrolysis. However, liquid‐phase CO2 electrolysis often exhibits low CO2 reduction rates because of limited CO2 availability. Here, a macroporous Ag mesh is employed and activated to achieve selective CO2 conversion to CO with high rates from an aqueous bicarbonate solution. It is found that activation of Ag surface using oxidation/reduction cycles produces nanoporous surfaces that favor CO2‐to‐CO conversion. Notably, it is found that a combination of dissolved CO2 in bicarbonate solution with CO2 generated in situ from bicarbonate ions enables increased CO2 availability and a CO2‐to‐CO conversion rate over 100 mA cm−2. By optimizing the oxidation/reduction cycles to fine‐tune the structure of Ag surface, CO2‐to‐CO conversion is reported from a bicarbonate solution with CO Faradaic efficiency of over 85% at current density of 100 mA cm−2, high concentration of 24.7% at outlet gas stream and stability of over 100 h with maintaining CO FE over 85% during whole reaction time.
Solitary pulmonary metastasis at presentation in a dog with anal sac adenocarcinoma without nodal metastasis
Authors: Cotnoir Katelyn , Cook Matthew R. , Lapsley Janis , Grossman Elliot , Selmic Laura E. 
Published: December 2024

AbstractA 10‐year‐old, male, neutered labrador retriever was diagnosed with a left‐sided anal sac adenocarcinoma. At diagnosis, staging with an abdominal computed tomography revealed no intraabdominal lymph node enlargement. Thoracic radiographs revealed a soft tissue pulmonary nodule with cytology consistent with a carcinoma. The dog underwent a left anal sacculectomy, and re‐presented 24 days later for a lung lobectomy in which histopathology represented primary anal sac adenocarcinoma metastasis. Forty‐nine days after initial presentation, the dog was referred for a right distal radial lytic lesion in which cytology was concerning for osteosarcoma. After 132 days of initial presentation, an abdominal ultrasound revealed normal‐sized iliosacral lymph nodes. The dog was humanely euthanased 446 days after initial diagnosis. This case report describes a dog who had a solitary metastatic pulmonary nodule from apocrine gland anal sac adenocarcinoma at the time of presentation with no nodal metastasis identified, which is atypical compared to previous reports.
Optimal botulinum toxin therapy of dystonia in Germany: what would it cost?
Authors: Dressler Dirk , Altenmüller Eckart , Pan Lizhen , Saberi Fereshte Adib 
Published: December 2024

AbstractBotulinum toxin (BT) therapy is the therapy of choice for most forms of dystonia. We want to describe its costs, if all dystonia patients in Germany would have access to optimal BT therapy. For this, we combined the latest data on epidemiology of dystonia and dosing of BT therapy for dystonia. Missing data were generated for this study. Based on official German pharmacy sales prices, optimal treatment for all dystonia patients in Germany with a population of 84.1 million would generate annual drug costs of €155.5 million (cervical dystonia 89.3, tardive dystonia 22.1, generalised dystonia 17.9, blepharospasm 9.3, segmental dystonia 5.9, writer’s cramp 5.3, arm dystonia 3.2, oromandibular dystonia 2.3, musician’s dystonia 0.3, spasmodic dysphonia 0.1) This is €1.85 annually per capita or 0.3% of the total 2021 drug budget and 42% of the 2021 Parkinson drug budget of German public insurance companies. Actual costs for the health care system are considerably lower, as there are various discounts to consider. Further reductions would be possible. BT therapy’s individual costs are high. Its costs for the health care system, however, are marginal. Comparing projected and actual costs, would allow estimating availability and quality of BT therapy of dystonia in Germany.
Novel antibiotic resistance profiles in bacteria isolated from oil fly larvae Helaeomyia petrolei living in the La Brea Tar Pits
Authors: Durso Lisa M. , Shamimuzzaman Md. , Dillard Brian , Nickerson Kenneth W. 
Published: December 2024

AbstractLarvae from the petroleum oil fly, Helaeomyia petrolei, live in the asphaltene and polyaromatic hydrocarbon rich asphalt seeps of Rancho La Brea, Los Angeles, California. These larvae pass high amounts of viscous asphalt through their digestive system, and their gut microbiota is exposed to these extreme conditions. Environmental stress response mechanisms can co-select for antibiotic resistance, and in the current study we used 16S rRNA and genomic sequencing along with the Comprehensive Antibiotic Resistance Database (CARD) tools to characterize antibiotic resistance profiles from six bacteria previously isolated from the oil fly larval intestinal tract, linking phenotypic and genotypic resistance profiles. The isolates contain a core set of antibiotic resistance determinants along with determinants that are rarely found in these species. Comparing these oil fly isolates to the phenotypic prevalence data generated by the CARD Resistance Gene Identifier revealed sixteen instances where the oil fly bacteria appeared to carry a resistance not seen in related taxa in the database, suggesting a novel suite of resistance families in the oil fly isolates compared to other members of the same taxa. Results highlight the functional duality of genes that simultaneously code for antibiotic resistance and survival under extreme conditions, and expand our understanding of the ecological and evolutionary role of antibiotic resistance genes in environmental habitats.
Compensated velocity feedback for non-collocated active vibration control
Authors: Hirschfeldt Natasha , Furtmüller Thomas , Adam Christoph , Maderebner Roland 
Published: December 2024

AbstractThis paper addresses non-collocated vibration control of multi-modal structures such as plates. The challenges of applying this non-collocated configuration in real systems are tackled by proposing a second-order compensator using velocity feedback control. The compensator design aims to use uncontrolled data only, where its parameters are obtained from a measurement of the point-frequency response function at the actuator attachment point (anti-resonance assignment). Compared to other control strategies such as optimal control, no plant model or state estimation is required in the hardware implementation of the controller, making this approach relatively simple. The compensator design is outlined for a generic three-degree-of-freedom system, as its simplicity allows for deeper investigation of the effects of the compensator itself. The proposed design is then experimentally validated by vibration control of a cross-laminated timber panel, considering three closely spaced natural frequencies. Further difficulties encountered in dealing with real world systems are discussed by comparing experimental data with simulations. To achieve this, a model of the electromechanical system composed of the panel and two electrodynamic shakers is used. The parameters of the compensator for the system are then obtained and a sensitivity study to these parameters is carried out by calculating a control performance taking into account filters and the effects of time delay.
Evaluation and Dissection of Sensory Quality Traits for Potato Taste
Authors: Wang Ying , Yang Wan-lin , Zeng Fan-kui , Lei Chun-ni , Yang Qiong-fen , Wang Jian 
Published: December 2024

AbstractThe sensory qualities of potatoes significantly influence consumer preference. This study evaluated the sensory qualities of 66 potato varieties, focusing on representatives of distinct taste types for detailed analysis: sensory evaluation, taste, nutritional components, texture properties, physicochemical characteristics of starch, and volatile aroma compounds. Sensory evaluation of these potato varieties identified the landrace “Kaihua Yangyu” as the most favoured by consumers. The favourable taste of Kai Hua Yang Yu was attributed to (1) soft, dry, and non-sticky texture; (2) starch with higher peak viscosity, easier gelatinisation (below 70 ℃), higher setback value (2776 RVU), and larger granule size (41.63 ± 9.90 μm) compared with other such as YS105 and Cooperation88; and (3) distinctive umami flavour, a trait notably associated with elevated levels of aspartic acid and glutamic acid.
Magma Ocean Evolution at Arbitrary Redox State
Authors: Nicholls Harrison , Lichtenberg Tim , Bower Dan J. , Pierrehumbert Raymond 
Published: December 2024

AbstractInteractions between magma oceans and overlying atmospheres on young rocky planets leads to an evolving feedback of outgassing, greenhouse forcing, and mantle melt fraction. Previous studies have predominantly focused on the solidification of oxidized Earth‐similar planets, but the diversity in mean density and irradiation observed in the low‐mass exoplanet census motivate exploration of strongly varying geochemical scenarios. We aim to explore how variable redox properties alter the duration of magma ocean solidification, the equilibrium thermodynamic state, melt fraction of the mantle, and atmospheric composition. We develop a 1D coupled interior‐atmosphere model that can simulate the time‐evolution of lava planets. This is applied across a grid of fixed redox states, orbital separations, hydrogen endowments, and C/H ratios around a Sun‐like star. The composition of these atmospheres is highly variable before and during solidification. The evolutionary path of an Earth‐like planet at 1 AU ranges between permanent magma ocean states and solidification within 1 Myr. Recently solidified planets typically host ‐ or ‐dominated atmospheres in the absence of escape. Orbital separation is the primary factor determining magma ocean evolution, followed by the total hydrogen endowment, mantle oxygen fugacity, and finally the planet's C/H ratio. Collisional absorption by induces a greenhouse effect which can prevent or stall magma ocean solidification. Through this effect, as well as the outgassing of other volatiles, geochemical properties exert significant control over the fate of magma oceans on rocky planets.
Probing the influence of imidazolylidene- and triazolylidene-based carbenes on the catalytic potential of dioxomolybdenum and dioxotungsten complexes in deoxygenation catalysis
Authors: Neururer Florian R. , Heim Florian , Baltrun Marc , Boos Philipp , Beerhues Julia , Seidl Michael , Hohloch Stephan 
Published: December 2024

We report the synthesis of molydenum and tungsten NHC and MIC complexes with the general formula (OCO)MO2 (OCO = bis-phenolate NHC/MIC; M = Mo, W) and their utility in the catalytic deoxygenation of nitroarenes.
Les mots qui font guérir l’enfant
Authors: Abramson Irit 
Published: December 2024

Personne ne connait les mots qui font guérir l’enfant. Lui seul peut les trouver ou, par ses conduites, induire des questions faisant écho à sa souffrance. Ce qu’il éprouve cherche toujours à se faire entendre, non seulement à travers le langage parlé, mais avec tout ce qui fait langage. Il n’y a pas de symptôme qui ne s’accompagne d’un quelconque indice moteur ayant déjà eu une fonction de communication. L’enfant s’y réfère comme à une manière de dire.
L’auteur explique la notion de remémoration à partir d’histoires individuelles, chacune d’elles montrant les étapes du déchiffrage des troubles de l’enfant. Derrière le récit des blocages ou des somatisations qui inquiètent les parents, il s’agit de comprendre ce que dit l’enfant de lui-même quand il parle. Ses réactions au langage font entendre des questions sur les souffrances non dites, mais aussi la partie la plus méconnue de lui-même, inconsciente, qui se matérialise sous la forme d’attitudes parlantes. Pour comprendre sa souffrance, il nous faut regarder ce qu’il montre avec son corps.
Revisiter la question de l’adolescence
Authors: Quentel Jean-Claude 
Published: December 2024

La clinique de l’adolescent oblige à s’interroger sur les processus qui se mettent en place à la sortie de l’enfance. Elle conduit notamment à creuser la fameuse « subjectivation » qui se ferait véritablement jour à cette époque. La théorie de la médiation de Jean Gagnepain, en dissociant la problématique du désir de celle de l’être, autrement dit le registre du pulsionnel et celui de l’identitaire, vient sur ce point conforter de diverses manières les élaborations théoriques des psychanalystes qui ont fait le choix de travailler avec des adolescents. Elle les enrichit par ailleurs d’une conception dialectique du fonctionnement de l’être.
Endovascular Treatment of Type II Endoleaks: Update and Overview
Authors: Dalzell Christina G. , Sheeran Daniel P. , Angle John F. , Wilkins Luke R. 
Published: December 2024

AbstractEndoleaks are a common complication following endovascular aneurysm repair, despite EVAR being the preferred method for the repair of abdominal aortic aneurysms. Endoleaks are continued blood flow into the aneurysmal sac, or more broadly elevated pressure outside of the endograft, and are classified into five types based on the source of blood flow or elevated pressure. Type II endoleaks are the most common and are a result of retrograde flow to the sac most commonly from the inferior mesenteric artery or lumbar artery. Endovascular treatment options for type II endoleaks include transarterial, transcaval, translumbar, and transabdominal approaches. This review discusses the indication for endovascular treatment of type II endoleaks, the selection of approach, and technical considerations.
An Investigation on the Component Efficiencies of Supersonic Ejector
Authors: Samant Arpit , Shukla Rahul 
Published: December 2024

Abstract
This report aims to investigate different component efficiencies present in CRKEC based ejector model. This study calculates the efficiencies of component on-design and off-design condition. This study shows the effect of the inlet, secondary, and exit pressure on the efficiencies of the nozzle, mixing, diffuser and entrainment efficiency of supersonic ejector. The literature’s definitions of ejector component efficiencies are listed below. There is a discussion of how ejector shapes, operating circumstances, and working fluid properties affect ejector efficiency. Future studies on ejector efficiency, ideal design, and control of ejectors and ejector systems will benefit from this research. The literature’s definitions of ejector component efficiencies are listed below.
A new tool to solve data related problem with source coding theorem
Authors: Dwivedi Aakanksha , Naresh Saraswat Ram 
Published: December 2024

Abstract
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