bluuebunny/crossref_metadata_2025_split huggingface dataset:
Striatal Cholinergic Dysregulation after Neonatal Decrease in X‐Linked Dystonia Parkinsonism‐Related TAF1 Isoforms
Authors: Cirnaru Maria‐Daniela , Creus‐Muncunill Jordi , Nelson Shareen , Lewis Travis B. , Watson Jaime , Ellerby Lisa M. , Gonzalez‐Alegre Pedro , Ehrlich Michelle E. 
Published: August 2021

ABSTRACTBackgroundX‐linked dystonia parkinsonism is a generalized, progressive dystonia followed by parkinsonism with onset in adulthood and accompanied by striatal neurodegeneration. Causative mutations are located in a noncoding region of the TATA‐box binding protein‐associated factor 1 (TAF1) gene and result in aberrant splicing. There are 2 major TAF1 isoforms that may be decreased in symptomatic patients, including the ubiquitously expressed canonical cTAF1 and the neuronal‐specific nTAF1.ObjectiveThe objective of this study was to determine the behavioral and transcriptomic effects of decreased cTAF1 and/or nTAF1 in vivo.MethodsWe generated adeno‐associated viral (AAV) vectors encoding microRNAs targeting Taf1 in a splice‐isoform selective manner. We performed intracerebroventricular viral injections in newborn mice and rats and intrastriatal infusions in 3‐week‐old rats. The effects of Taf1 knockdown were assayed at 4 months of age with evaluation of motor function, histology, and RNA sequencing of the striatum, followed by its validation.ResultsWe report motor deficits in all cohorts, more pronounced in animals injected at P0, in which we also identified transcriptomic alterations in multiple neuronal pathways, including the cholinergic synapse. In both species, we show a reduced number of striatal cholinergic interneurons and their marker mRNAs after Taf1 knockdown in the newborn.ConclusionThis study provides novel information regarding the requirement for TAF1 in the postnatal maintenance of striatal cholinergic neurons, the dysfunction of which is involved in other inherited forms of dystonia. © 2021 International Parkinson and Movement Disorder Society
Identification of seven psychedelic 2,5‐dimethoxy‐phenylethyl‐amine‐based designer drugs via benchtop 1H nuclear magnetic resonance spectroscopy
Authors: Araneda Juan F. , Baumgarte Marion , Lange Marie , Maier Alexander F. G. , Riegel Susanne D. 
Published: August 2021

AbstractThe dissemination of spectral information of new psychoactive substances (NPS) acquired on benchtop nuclear magnetic resonance (NMR) spectrometers is of high importance considering the emerging application of such portable and accessible instruments in forensic analyses. Seven members of the 2C‐X series (2C‐B, 2C‐C, 2C‐D, 2C‐E, 2C‐P, 2C‐T2, and 2C‐T7) of NPS were analyzed via 60 MHz 1H benchtop NMR spectroscopy and their molecular structural relations are discussed with respect to the observed proton NMR spectra.
Examining the meaning of the language used to communicate the nursing hand‐off
Authors: Galatzan Benjamin J. , Carrington Jane M. 
Published: August 2021

AbstractThe miscommunication and inconsistent recall of patient information due to cognitive lapses that occur during the hand‐off between healthcare providers account for 80% of sentinel events in acute care. Cognitive lapses are a consequence of the nurse experiencing cognitive overload, which impedes the nurse's ability to recall relevant information during and after the hand‐off communication. The primary cognitive and human factor contributing to cognitive overload in the hand‐off is language. The purpose of this study was to examine the meaning of the language used to communicate the nurse‐to‐nurse change of shift hand‐off occurring at bedside and nonbedside on a medical‐surgical unit in an urban medical center. A qualitative descriptive design was used. The sample was 10 audio‐recorded hand‐offs (five bedside and five nonbedside), with a total of 19 nurses participating. A natural language process program was used to analyze the data. The hand‐off is a narrative story centered on communicating patient information delivered with a high degree of confidence. The hand‐off is focused on past and current events with minimal focus on future or anticipated events. The drive to communicate is minimally based on concern, fear, or danger. There is a difference in the language used to communicate the nursing hand‐off message at bedside as compared to the nonbedside hand‐off.
Terephthalic Acid Copolyesters Containing Tetramethylcyclobutanediol for High‐Performance Plastics
Authors: Bhagia Samarthya , Bornani Kamlesh , Ozcan Soydan , Ragauskas Arthur J. 
Published: August 2021

AbstractThere is a need for high‐performance applications for terephthalic acid (TPA) polyesters with high heat resistance, impact toughness, and optical clarity. Bisphenol A (BPA) based polycarbonates and polyarylates have such properties, but BPA is an endocrine disruptor. Therefore, new TPA polyesters that are less hazardous to health and the environment are becoming popular. Tetramethylcyclobutanediol (TMCD) is a difunctional monomer that can be polymerized with TPA and other diols to yield copolyesters with superior properties to conventional TPA polyesters. It has a cyclobutyl ring that makes it more rigid than cyclohexanedimethanol (CHDM) and EG. Thus, TMCD containing TPA copolyesters can have high heat resistance and impact strength. TPA can be made from abundantly available upcycled polyethylene terephthalate (PET). Therefore, this review discusses the synthesis of monomers and copolyesters, the impact of diol composition on material properties, molecular weight, effects of photodegradation, health safety, and substitution of cyclobutane diols for future polyesters.
Effect of graphene nanoparticles on the strength of sandwich structure inspired by dragonfly wings under low‐velocity impact
Authors: Rezvani Tavakol Mehdi , Yarmohammad Tooski Mehdi , Jabbari Mohsen , Javadi Mehrdad 
Published: August 2021

AbstractDragonfly's wings are highly specialized flying organs that are well adapted to the flying behavior of each dragonfly, mainly consisting of veins and membrane. The effect of graphene nanoparticles on a novel foam‐based sandwich panel structure inspired by microstructural features of dragonfly wings has been investigated under low‐velocity impact. Composite and nanocomposite sandwich veins are made of E‐glass/epoxy layers, in which different percentages of graphene nanoparticles are combined with its resin. Polyurethane foam was also used for its core. According to the performance of the samples made after testing and cutting the samples in transverse and longitudinal directions, the internal structure of the vein was examined. Sandwich panels with this type of structure under impact can prevent damage propagation in the vein. The sandwich structure with 0.3% nano indicated more stable behavior in energy absorption and impact resistance than other samples.
Biocomposites with high strength and thermal and noise insulation by reinforcing polypropylene with stems and fibers from Arundinaria gigantea
Authors: Hu Chunyan , Vittal Jayanth , Guna Vijaykumar , Zhao Yi , Chikkamaranahalli Boganarasimhaiah Mohan , Reddy Narendra 
Published: August 2021

AbstractArundinaria gigantea commonly referred to as giant cane (GC) shows potential to be a sustainable, renewable, and low‐cost source for natural cellulose fibers and biocomposites. GC is considered a weed and is found extensively, particularly along river banks and also as canopy under forest trees. The grass is made up of stems (culms) that resemble bamboo but with smaller diameters. In this study, the possibility of extracting natural cellulose fibers from the culms and also to utilize the culms directly as reinforcement for polypropylene (PP) biocomposites has been explored. Natural cellulose fibers extracted from the culms had cellulose content of about 50%. The fibers had considerably high tensile strength of 543 MPa and elongation of 5.6%. Biocomposites with varying tensile and flexural properties could be obtained depending on the proportion of the reinforcement and matrix and density of the biocomposites. Furthermore, reinforcing PP with GC increased acoustic sorption but decreased thermal conductivity. GC offers potential to develop fibers and biocomposites with desired properties as a substitute to the conventional lignocellulosic fibers obtained from fiber crops.
Centrifugally spun poly(ethylene oxide) fibers rival the properties of electrospun fibers
Authors: Merchiers Jorgo , Martínez Narváez Carina D. V. , Slykas Cheryl , Buntinx Mieke , Deferme Wim , D'Haen Jan , Peeters Roos , Sharma Vivek , Reddy Naveen K. 
Published: August 2021

AbstractCentrifugal force spinning (CFS), also known as centrifugal spinning, forcespinning, or rotary jet spinning, provides considerably higher production rates than electrospinning (ES), but the more widespread use of CFS as an alternative depends on the ability to produce fibers with robust thermal and mechanical properties. Here, we report the CFS of poly(ethylene oxide) (PEO) fibers made using a spinning dope formulated with acetonitrile (AcN) as the volatile solvent, and we describe the thermal and mechanical properties of the centrifugally‐spun fibers. Even though the formation, diameter, and morphology of electrospun and centrifugally‐spun PEO fibers are relatively well‐studied, the article presents three crucial contributions: the pioneering use of PEO solutions in AcN as spinning dope, characterization of crystallinity and mechanical properties of the centrifugally‐spun PEO fibers, and a comparison with the corresponding properties of electrospun fibers. We find that fiber formation occurrs for the chosen CFS conditions if polymer concentration exceeds the entanglement concentration, determined from the measured specific viscosity. Most significantly, the centrifugally spun PEO fibers display crystallinity, modulus, elongation‐at‐break, and fiber diameter that rival the properties of electrospun PEO fibers reported in the literature.
On assessing functional errors in density functional theory using atomisation energies and electric field gradients
Authors: Littlefair Josh D. , Cole Daniel J. , Penfold Thomas J. 
Published: August 2021

AbstractDespite the exact form of Exc being unknown, remarkably simple approximations can provide unrivaled accuracy to cost ratio. Both physically and empirically motivated approaches for developing Exc are used, but nearly all focus upon improving calculated energies. Herein we simultaneously study energy and density errors associated with a range of density functionals for CuCl and four related complexes. Atomisation energies are compared with high‐level coupled cluster, CCSD(T), while computed electric field gradients are compared with those obtained from microwave spectroscopy and CCSD(T). We show that simple metrics are able to reveal the relative contributions of the energetic errors associated with the use of an approximate density and an approximate exchange and correlation functional. The methods adopted provide a potentially useful approach for assessing and developing new balanced functionals that are able to provide simultaneous improvement in both energetics and properties associated with the electron density.
Erythrokeratoderma Variabilis (EKV) – First Nepalese Case Documenting GJB3 Mutation
Authors: Shah M. , Baral S. , Adhikari R. C. 
Published: August 2021

Abstract
Erythrokeratoderma Variabilis (EKV) is a rare genodermatosis, characterized by variable erythematous and hyperkeratotic skin lesions. It is most often transmitted in autosomal dominant manner (AD). Casual mutations were found in the GJB3 and GJB4 genes encoding connexins 31 and 30.3, respectively. We report a 7-year-old girl with multiple dusky red and brown skin lesions on face, buttock, both arms and legs. This diagnosis was made on the basis of clinical and histological findings and further genetic analysis detected a G &gt; C transition at position 125 of the coding sequence, which replaces arginine with a proline at residue 42 of the protein (R42P). Here, we report a first case of Nepalese patient with EKV resulting from the GJB3 mutation.
AIE Effect by Oxygen Clustering in Vegetable Oil‐Based Polymers
Authors: Alarcon Rafael T. , Gaglieri Caroline , dos Santos Giovanny C. , Moralles Ana C. , Morgon Nelson H. , de Souza Aguinaldo R. , Bannach Gilbert 
Published: August 2021

AbstractVegetable oil has been widely used to synthesize monomers and polymers in different fields. Some authors have found different polymers in maleinized vegetable oil; however, they have not described the luminescent properties of the polymers in an intensive way. This work aimed to synthesize new polymers from macadamia oil using diethylene glycol and glycerol as crosslinkers and their characterization The results obtained by spectroscopic analyses confirmed the incorporation of anhydride, as well as the reactions for the final polymers. Results from UV‐Vis showed that maleinized macadamia oil presented an aggregation‐induced emission effect with solvatochromic effect with absorption at 201.6 nm (ethanol) and 241.8 nm (chloroform), which was corroborated by theoretical calculations. Moreover, the luminescent property exhibited by both obtained polymers was kept even after the swelling test, and powdering the samples. Therefore, these polymers, synthetized in a fast way and without catalyst, open a new field of renewable and sustainable materials with luminescent properties that can be applied in technological fields, such as solar cells and fluorescent sensors.
Enantioselective Cross‐Aldol Reaction with Ketones and Non‐Enolizable Ketones Catalyzed by Tetrapeptides
Authors: Wang Pei , Zhang Yang , Yang Hong , Ma Guo‐Rong , Wang Jin‐Bao , Yang Wen , Du Zhi‐Hong , Da Chao‐Shan 
Published: August 2021

AbstractAn efficient strategy shaping the construction of (R)‐3‐alkyl‐3‐hydroxyindolin‐2‐one and (S)‐5‐trifluoromethyl‐4‐hydroxy‐4‐arylpentan‐2‐one derivatives catalyzed by the β‐turn tetrapeptide catalyst under mild conditions was developed. Various isatins and ketones could participate in this reaction, and the desired adducts were obtained with excellent yield (up to 99 %) and moderate to high enantioselectivity (ee up to 85 %) and excellent diastereoselectivity (dr up to >20 : 1). Moreover, a series of trifluoromethyl ketones with ketones also could participate in this reaction, and the resulting β‐trifluoromethyl‐β‐hydroxy ketones with excellent yields and moderate enantioselectivities (ee up to 58 %) were obtained. In addition, the strategy afforded better results than natural papain.
Green Synthesis of Bis(pyrazol‐5‐ole) and Pyrazolopyranopyrimidine Derivatives through Mechanochemistry Using Chitosan as a Biodegradable Catalyst
Authors: Chowhan Bushra , Kour Jaspreet , Gupta Monika , Paul Satya 
Published: August 2021

AbstractGrinding assisted, simple and green route for the synthesis of bis(pyrazol‐5‐ole) and pyrazolopyranopyrimidine using chitosan as a biodegradable catalyst is developed. This protocol offers selective synthesis of bis(pyrazol‐5‐ole) and pyrazolopyranopyrimidine without any side product with excellent yield and shorter duration. Moreover, this method provides metal‐free synthesis and put forward easy separation in gram scale synthesis which makes the protocol sustainable. The recyclability of the catalyst is also simple and carried upto eight consecutive runs. In addition, SEM images and powder XRD of fresh and recycled catalysts are also compared.
Enhanced Charge‐ Discharge Behaviour of MnFe2O4 laden Composite Cathode for Lithium‐Sulfur Batteries
Authors: Mathew Deepa Elizabeth , Rani G. Jenita , Jenis D. Ponraj , Thomas Sabu , Stephan A. Manuel 
Published: August 2021

AbstractThe Li−S battery commercialization has been hampered owing to challenging problems such as poor conductivity of elemental sulfur, volume change upon cycling, and shuttling of lithium polysulfide between the electrodes. To conquer these issues, a sensible electrode structure design is crucial. The incorporation of carbonaceous materials and metal oxides has been identified as an effective tool to foster the electrochemical properties of Li−S batteries. In this work, to confine polysulfide shuttling and to improve the conductivity of sulfur, MnFe2O4‐seated rGO‐sulfur composite was prepared and used as a cathode. The lithium‐sulfur cell with MnFe2O4‐seated rGO‐sulfur composite cathode showed outstanding electrochemical performance delivering a discharge capacity of 1300 mAh g−1 at 0.1 C‐rate on its first cycle and a stable cycling was attained at 0.5 C‐rate. In the composite cathode, each component functions for a specific reason: the rGO in the composite improves the conductivity of sulfur, while added‐ MnFe2O4 not only confines polysulfides appreciably but also provides integrity to the cathode as evidenced by SEM analysis. The self‐discharge studies showed that the Li−S cell with MnFe2O4 was capable of retaining its charge even after 90 h which has overhead the earlier reports. The Li−S system with MnFe2O4 ‐laden cathode material exhibited better electrochemical properties than the un‐laden one.
Preparation of Melamine Foam Supported Nanoscale Zero Valent Iron and Its Application for Removal of Cr(VI) from Aqueous Solution and Hydrogenation of p‐Nitrophenol
Authors: Gao Kangqi , Su Wen , Song Jianjun 
Published: August 2021

AbstractIn this work, PEG‐nZVI@MF composites were prepared by immobilizing nanoscale zero valent iron (nZVI) on melamine foam (MF) through the incorporation of polyethylene glycol (PEG). As a monolithic, low‐cost, and efficient catalyst, PEG‐nZVI@MF catalyst showed excellent performance in the removal of Cr(VI) from aqueous solution and catalytical hydrogenation of p‐nitrophenol (p‐NP). The hydrogenation of p‐NP by sodium borohydride was completed within 3 min, and PEG‐nZVI@MF catalyst showed excellent catalytic performance without sacrificing catalytic activity during four cycle reactions. In addition, 99 % of Cr(VI) ions in an aqueous solution were removed within 15 min. Importantly, the novel composite could be simply separated by a common external magnet. This synthesis strategy here provided a simple method to prepare air stable nZVI composites for environment remediation.
Boron Nitride doped Chitosan Functionalized Graphene for an Efficient Dye Degradation
Authors: Khose Rahul V. , Lokhande Kshama D. , Bhakare Madhuri A. , Dhumal Pratik S. , Wadekar Pravin H. , Some Surajit 
Published: August 2021

AbstractIn this article, we have developed a simple and highly effective method for synthesis of boron nitride, chitosan and graphene‐based composite (BNCG). The BNCG has been synthesized by using cheap precursors such as boric acid, melamine, chitosan, and graphene oxide in a seal tube under nitrogen atmosphere and applied to degrade methylene blue. The dye degradation of methylene blue (MB) and Acid orange II (AO II) has been carried out using sunlight. The effective degradation of dye takes place at basic pH. The 10, 25, and 50 ppm of dye has successfully degraded in 10 min. of time. The degradation study concluded that about 87 % of the MB and 57 % AO II dye were degraded by BNCG composite. The degradation follows the first order kinetics as per the observed results. This preparative method and BNCG composite will overcome complicated preparative steps and a long time for dye degradation.
Design and Synthesis of Metastable 4H‐3,1‐Benzoxazin‐4‐one and 3‐aminoquinazoline‐4(3H)‐one for Detecting Cations in Water Samples and Agricultural Crops
Authors: Algohary Ayman M. , Elamin Manahil B. , Ahmed Amani H. , El‐Hashash Maher A. , Radwan Tasnim M. 
Published: August 2021

AbstractThe behaviour of 2‐benzyl‐4H‐3,1‐benzoxazin‐4‐one towards nitrogen nucleophiles namely, amino acids, aromatic amines, sodium azide, and secondary amines has been investigated. Also the reaction of 3‐amino‐2‐benzylquinazolin‐4(3H)‐one and 2‐[2‐benzyl‐4‐oxoquinazolin‐3(4H)‐yl]acetohydrazide with carbon electrophiles has been discussed. As well as The novel synthesized compounds were evaluated as chemosensor for detecting formyl, carbonyl group and revealed high‐selectivity and specificity to detect metals ions in water samples and, agricultural crops. Qualitative and quantitative assays indicated appreciable selectivity of novel compounds 13 and 15 as a chemo sensor for Optical detection of Hg2+and Cr2+ respectively.
In‐vitro Anticancer and Molecular Docking Studies of 4‐Azaindole‐1,2,4‐Oxadiazole Hybrids
Authors: Sagam Ravikumar Reddy , Nukala Satheesh Kumar , Nagavath Rajkumar , Sirassu Narsimha , Gundepaka Prasad , Manchal Ravinder , Thirukovela Narasimha Swamy 
Published: August 2021

AbstractThe synthesis of some novel 4‐azaindole‐1,2,4‐oxadiazole hybrids (5 a–5 q) from the reaction between 1H‐pyrrolo[3,2‐b]pyridine‐3‐carbonitrile and readily available aromatic carboxylic acids using was described herein. All these hybrids were evaluated for their in vitro anticancer activity against three human cancer cell lines namely A375 (melanoma), MCF7 (breast) and A549 (lung) using MTT assay and outcomes revealed that three compounds like 5 c, 5 f and 5 m displayed superior inhibitory activities against all the cell lines than the standard. In those, predominantly, the compound 5 m showed outstanding activity in MCF‐7 cell line possessing IC50 values 0.48 μM. In addition, the in silico studies of three potent compounds 5 c, 5 f and 5 m were carried out to identify the interactions against EGFR receptor and found that the energy calculations were in good agreement with the obtained IC50 values. Furthermore, the compounds 5 c, 5 f and 5 m exhibited promising inhibitory activity against tyrosine kinase EGFR. Among them, the compounds 5 f and 5 m displayed superior activity against tyrosine kinase EGFR when compared with the standard Erlotinib.
Polyaniline‐Supported Tungsten‐Catalyzed Green and Selective Oxidation of Alcohols
Authors: Sun Hong , Shi Yaocheng , Fu Weijun , Yu Lei 
Published: August 2021

AbstractPolyaniline (PANI)‐supported tungsten could be easily fabricated by immersing PANI into the tungsten salt solution. It was a high efficient catalyst for alcohol oxidation reaction to produce carbonyls. Notably, the selectivities of the oxidation of primary alcohols were good, affording aldehydes as the specific products. The high catalytic activity might attribute to the coordination of nitrogen in PANI with tungsten in the materials, while the unique structure afforded the catalyst high selectivity for primary alcohol oxidation.
Effect of Acid Treatment on the Catalytic Activity and Mechanical Stability of SmMnO3/Cordierite Monolithic Catalysts
Authors: Bao Lei , Wu Dongfang 
Published: August 2021

AbstractSmMnO3/cordierite monolithic catalysts were synthesized by a modified citric acid method and treated with dilute HNO3, which was used to explore the effect of acid treatment on the catalytic performance and mechanical stability of the monolithic catalysts. Firstly, acid treatment can significantly improve catalytic activity of catalyst in o‐xylene oxidation, which is attributed to the increase of the specific surface area of the catalyst and the change of surface oxygen species. A series of single factor experiments show that the SmMnO3/cordierite monolithic catalyst treated by 1.0 mol/L HNO3 for 6 h and calcined at 450 °C for 1 h has the best performance. Furthermore, the mechanical stability of the catalysts treated by dilute HNO3 was tested, which show that too long acid treatment time and too high acid concentration will reduce the mechanical stability of the catalyst and 1.0 mol/L HNO3 treatment for 1 h is the best. Different calcination temperature and calcination time will also affect the mechanical stability of the catalyst. Finally, the catalyst has good stability of catalytic performance and mechanical stability.
Synthetic Approach to Oxacycles via the Application of Ring‐Rearrangement Metathesis
Authors: Kotha Sambasivarao , Fatma Ambareen 
Published: August 2021

AbstractThe design and synthesis of polycycles containing epoxy moeity ring system is described via the application of Grignard reaction and ring‐rearrangement metathesis as key steps. The synthesis of oxabowls using O‐allylation and ring‐rearrangement metathesis is also presented.