bluuebunny/crossref_metadata_2025_split huggingface dataset:
A characteristic occipital epileptiform EEG pattern in ADCK3‐related mitochondrial disease
Authors: Arntsen Vibeke , Sand Trond , Hikmat Omar , Samsonsen Christian , Bindoff Laurence A. , Brodtkorb Eylert 
Published: May 2021

AbstractObjective. ADCK3‐related disease is a mitochondrial disorder associated with an abnormality of coenzyme Q10 metabolism. Ataxia and epilepsy are common, and the phenotype overlaps with other mitochondrial encephalopathies, particularly POLG‐related disease. CoQ10 supplementation may be beneficial. We have noted a remarkable epileptiform pattern in ADCK3‐related encephalopathy, and since EEG studies in this rare condition are limited, we wished to assess the evolution of EEG characteristics in patients with this disorder.Methods. All EEG recordings of the four known patients from Mid‐Norway were systematically reviewed. EEG graphoelements were classified according to the standardized computer‐based organized reporting of EEG (SCORE) and international glossary terms. The evolution of EEG features was assessed. A total of 96 recordings spanning over 15–32 years were available, with a mean of 24 per patient (range: 17–28). Altogether, 50 digital recordings were reviewed, including four long‐term and 46 selected paper segments.Results. In three patients, EEG showed prominent bilateral asynchronous and synchronous epileptiform discharges in occipital and posterior‐temporal regions. This intense activity included multiple epileptiform graphoelements, which occurred continuously, nearly continuously or in prolonged runs. The findings remained stable over many years.Significance. Although the number of patients is small, we suggest that interictal EEG findings of continuous/nearly continuous bi‐occipital spike‐waves may serve as a biomarker for this potentially treatable condition. This peculiar EEG pattern might help to differentiate ADCK3‐related disease from the more common POLG‐related disease, which is usually characterized by lateralized or focal slowing with more sporadic epileptiform elements of similar topography.
Effect Of Cupping Massage and Modified Spinal Decompression Therapy With Exercise Therapy in Neck Radiculopathy Syndrome
Authors: Et. al. Al-Jazzazi, Saleem. Abdulmageed, 
Published: May 2021

Cervical radiculopathy Syndrome (CRS) is a common neuro-musculo-skeletal disorder causing pain and disability. Manual therapy interventions including cervical traction with other treatment modalities have been advocated to decrease pain and disability caused by cervical radiculopathy (CR). Al-Qudah & AL-Jazzazi (2021) conducted a new method of Spinal Decompression Therapy (SDT) in patients with Chronic Lumbar Disc Herniation (CLDH) which includes Combination of Lumbar Traction With Cervical Traction (CLTCT) as one intervention. Despite of that this new method clinically reduces pain and disability more effectively than the conventional types of Traction, CLTCT method was not previously used in CR patients nor with Cervical Disc Herniation (CDH). The clinical effectiveness of this new method with other treatment modalities in patients with CRS was not approved yet. OBJECTIVE: The purpose of the presented work is to identify the effectiveness of rehabilitative program on patients with Cervical Radiculopathy, by (15) sessions for (4) Weeks. The suggested Rehabilitative program consisted of: 1.Supine Soft Full Back, Shoulders and Neck Cupping Massage (CM) for (10) minutes, 2.CLTCT: Combined Lumbar Traction with Cervical Traction as one intervention for (20) minutes, 3.Gradual Therapeutic Exercise Package of Neck Stretching and Strengthening Exercise for approximately (15) minutes. METHODS: In this study, Five outdoor male patients had accepted to participate and were randomly chosen from Al-Karak Governmental Hospital, All subjects applied the proposed rehabilitative program. The results were analyzed using the SPSS system. RESULTS: indicates that there was statistically significant difference between the pre and post measurements in favor of the post measurements in terms of Pain, Disability. CONCLUSIONS: The present study demonstrated that the use of proposed rehabilitative program has a positive effect on patients with Cervical Radiculopathy.
Representação da música das minorias: reflexões sobre a China
Authors: Qi Nan , Cesetti Durval 
Published: May 2021

Este artigo oferece uma perspectiva histórica sobre as 55 minorias étnicas oficiais da China e descreve como suas músicas (e culturas, de forma geral) são representadas pela educação musical e mídia chinesas. Tendo sido resultado de uma revisão bibliográfica sobre o assunto, o artigo descreve desde a forma como as minorias eram vistas de acordo com a doutrina confucionista, passando pelo maoísmo e chegando à China moderna, após os eventos da Praça da Paz Celestial e o crescimento econômico acelerado do país. Com os avanços feitos nas últimas décadas, houve um aumento significativo da representação étnica na educação musical e na mídia, com o resgate de inúmeras tradições que estavam a caminho do esquecimento; ao mesmo tempo, o artigo descreve os aspectos negativos e objetivos ocultos por trás destes avanços promovidos pelo governo, especialmente em relação às tensões separatistas dos povos tibetano e uigur. O artigo comenta como a música pode ser usada para “exoticizar” as minorias e promover sentimentos patrióticos e de unidade. Enquanto a educação musical patriótica tem sobressaído nas últimas décadas, discutimos também como a política de maior valorização das culturas étnicas minoritárias tem suscitado aumento de sentimentos de orgulho e de identificação étnica. Como conclusão, o artigo busca simplesmente enfatizar a importância de se descrever uma realidade complexa de forma complexa, com a coexistência de seus múltiplos aspectos positivos e negativos, salientando ao mesmo tempo a importância da conscientização de educadores musicais para seu importante papel na representação das minorias.
Генетическое разнообразие вируса SARS-CoV-2: Орловская область, декабрь, 2020 г
Authors: Водопьянов Алексей , Писанов Руслан , Подойницына Оксана , Кузнецова Дарья , Водопьянов Сергей , Чемисова Ольга , Румянцев Александр , Полякова Елена , Фролова Ирина , Махова Татьяна , Носков Алексей 
Published: May 2021

Распространение новой коронавирусной инфекции в субъектах Российской Федерации обусловлено последовательным вовлечением в эпидемический процесс различных групп восприимчивого местного населения с отличающимся иммунным статусом и, как следствие, сопровождается генетической изменчивостью вируса SARS-Cov-2, что в свою очередь может привести к формированию новых штаммов возбудителя. Стабилизация уровня заболеваемости населения и наметившаяся тенденция к ее снижению на фоне масштабных противоэпидемических (профилактических) мероприятий, в т.ч. прививочной кампании свидетельствует о необходимости изучения генетической вариабельности S-белка вируса SARS-Cov-2 являющегося основным компонентом вакцин в отдельно взятом субъекте Российской Федерации. В связи с этим, цель работы состояла в сравнительном анализе геномного разнообразия и полиморфизмов S-белка возбудителя COVID-19 циркулирующего на территории Орловской области.
Исследовано 100 образцов биологического материала от больных COVID-19 зарегистрированных в Орловской области. Секвенирование проводили на приборе MiSeq (Illumina, США), сборка геномов осуществлялась путем выравнивания на референсную последовательность уханьского варианта вируса SARS-Cov-2.
Установлено, что на территории Орловской области циркулируют штаммы возбудителя COVID-19 принадлежащие к ветви «B.1.1». Доминирующим вариантом для Орловской области является вариант B.1.1.130. В 54,1 % случаев в изученных образцах выявлен полиморфизм E484K Spike-белка, с которым ряд исследователей связывают уклонение от иммунного ответа макрорганизма.
Value Analysis of Anatomic and Reverse Shoulder Arthroplasty for Glenohumeral Osteoarthritis with an Intact Rotator Cuff
Authors: Polisetty Teja S. , Colley Ryan , Levy Jonathan C. 
Published: May 2021

Background:
While anatomic total shoulder arthroplasty (TSA) has historically been considered the ideal treatment for end-stage glenohumeral osteoarthritis, reverse shoulder arthroplasty (RSA) has recently gained popularity. With substantial differences in implant design and cost between TSA and RSA, further investigation of outcomes and value is needed to support recent trends. The purpose of this study was to use the average and incremental cost-effectiveness ratio (ACER and ICER) and the procedure value index (PVI) to examine differences in outcomes and value between TSA and RSA for treatment of glenohumeral osteoarthritis with an intact rotator cuff.

Methods:
We performed a retrospective matched-cohort study of patients treated with primary shoulder arthroplasty for osteoarthritis with an intact rotator cuff who had a minimum 2-year follow-up. Outcome measures analyzed included the Simple Shoulder Test (SST), American Shoulder and Elbow Surgeons (ASES) questionnaire, visual analog scale (VAS) for pain, Single Assessment Numeric Evaluation (SANE), and overall satisfaction. Patients treated with TSA were matched 4:1 to those treated with RSA based on sex, age, and preoperative SST score. Value differences between TSA and RSA were calculated. Radiographs were analyzed for preoperative glenoid classification and postoperative radiolucent lines and gross loosening.

Results:
Two hundred and fifty-two TSA-treated patients were matched to 63 RSA-treated patients with no significant differences in sex, age, or preoperative SST score. Total hospitalization costs, charges, and reimbursements along with outcome improvements in units of minimal clinically important differences (MCIDs) and patient satisfaction did not differ between the groups. For RSA, the implant cost was significantly higher than that for TSA, but the operating room, anesthesia, and cement costs were lower. The TSA group had a 3.2% rate of gross glenoid loosening and a 2.4% revision rate. There was no loosening or revision in the RSA group. None of the value analytics differed between groups even after inclusion of the outcomes and costs of early TSA revisions.

Conclusions:
TSA and RSA demonstrated similar outcomes and value when used to manage glenohumeral osteoarthritis with an intact rotator cuff.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Comparing 4-Year Changes in Patient-Reported Outcomes Following Ankle Arthroplasty and Arthrodesis
Authors: Sangeorzan Bruce J. , Ledoux William R. , Shofer Jane B. , Davitt James , Anderson John G. , Bohay Donald , Coetzee J. Chris , Maskill John , Brage Michael , Norvell Daniel C. 
Published: May 2021

Background:
The rate of total ankle arthroplasty (TAA) is increasing relative to ankle arthrodesis (AA) for patients seeking surgical treatment for end-stage ankle arthritis. Patients and providers would benefit from a more complete understanding of the rate of improvement, the average length of time to achieve maximal function and minimal pain, and whether there is a greater decline in function or an increase in pain over time following TAA compared with AA. The objectives of this study were to compare treatment changes in overall physical and mental function and ankle-specific function, as well as pain intensity at 48 months after TAA or AA in order to determine if the improvements are sustained.

Methods:
This was a multisite prospective cohort study that included 517 participants (414 TAA and 103 AA) who presented for surgical treatment. Participants were compared 48 months after surgery using the Foot and Ankle Ability Measure (FAAM) Activities of Daily Living and Sports subscales (0 to 100 points), the Short Form-36 (SF-36) Physical and Mental Component Summary (PCS and MCS) scores (0 to 100 points), and pain scores (0 to 10 points).

Results:
Both groups achieved significant improvement in the 2 FAAM measures, the SF-36 PCS score, and all of the pain measures at 48 months after surgey (p < 0.001). Mean improvements from baseline in patients undergoing TAA for the FAAM Activities of Daily Living, FAAM Sports, and SF-36 scores were at least 9 points, 8 points, and 3.5 points, respectively, which were higher than in those undergoing AA. Mean improvements in worst and average pain were at least 0.9 point higher in patients undergoing TAA than in those undergoing AA at 12, 24, and 36 months. These differences were attenuated by 48 months. For both treatments, all improvements from baseline to 24 months had been maintained at 48 months.

Conclusions:
When both procedures are performed by the same group of surgeons, patients who undergo TAA or AA for end-stage ankle arthritis have significant improvement in overall function, ankle-specific function, and pain at 48 months after surgery, with better functional improvement in the TAA group.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Complications of Intraosseous Access
Authors: Arakawa Jordan , Woelber Erik , Working Zachary , Meeker James , Friess Darin 
Published: May 2021

Cases:
Intraosseous (IO) access is an effective surrogate for intravascular access in critically ill patients. We present 2 cases of IO complications. The first patient is a 44-year-old man with deep peroneal nerve sensorimotor dysfunction due to possible missed acute compartment syndrome from improper placement of a tibial IO needle. The second patient is an immunosuppressed 69-year-old man with idiopathic factor VIII deficiency who required amputation 7 months after right tibia IO access.

Conclusion:
These adverse events of IO access are limited in the literature. We make recommendations to reduce these outcomes.
Prepatellar Glomus Tumor of the Knee without an Identifiable Mass on MRI
Authors: Berlinberg Elyse J. , Markus Danielle H. , Jour George , Strauss Eric J. 
Published: May 2021

Case:
A 71-year-old man presented with extreme anterior knee pain. His history, physical examination, and imaging were consistent with prepatellar bursitis, but his pain seemed out of proportion for these findings. The patient eventually underwent marginal excision of the inflamed prepatellar bursa which histopathology identified as a glomangioma. Postoperatively, he has complete resolution of his pain and has returned to his daily activities.

Conclusion:
Glomus tumors are a rare cause of severe knee pain that completely resolves after excision. In the patient with extreme, localized knee sensitivity, it is important to consider this pathology even if no mass is identified on imaging.
Palladium Nanoparticles on Modified Cellulose as a Novel Catalyst for Low Temperature Gas Reactions
Authors: Gioria Esteban , Signorini Chiara , Taleb María Claudia , Mihályi Magdolna , Gutierrez Laura 
Published: May 2021

Abstract
Palladium was incorporated into carboxymethylated cellulose fibers as a support, thereby becoming an efficient and stable catalyst for low temperature gas phase reaction. Thus, NO was used as test molecule of Greenhouse Gas to be catalytically reduced with hydrogen on an eco-friendly sustainable material containing palladium as the active site. Prior to the catalytic test, the catalysts were reduced with glucose as an eco-friendly reagent. The material characterization was performed by SEM-EDS, XRD, LRS, TGA and FTIR.The catalytic results showed that at 170°C, NO conversion was 100% with a selectivity of 70% to nitrogen. While NOX species were completely converted into N2 at temperatures higher than 180°C. The starting commercial material Solucell® was also studied, but its performance resulted lower than the ones of functionalized fibers.The use of this strategy, i.e., the functionalization of cellulose fibers followed by in-situ formation of metallic nanoparticles, can be further applied for the design of a wide range of materials with interesting applications for gas and liquid phase reactions under mild conditions.
Tetracarbonate melts and the fate of primordial carbon in the deep Earth
Authors: Cerantola Valerio , Sahle Christoph , Petitgirard Sylvain , Wu Min , Checchia Stefano , Weis Christopher , Michel Marco Di , Vaughan Gavin , Collings Ines , Arató Róbert , Wilke Max , Jones Adrian , Hanfland Michael , Tse John 
Published: May 2021

Abstract
Much of Earth’s carbon is thought to have been stripped away from the silicate mantle by dense metallic-iron to form the core1. However, recent studies2,3 suggest that a considerable part of it could have remained stranded in the deep mantle due to a change in its affinity to dissolve into iron metal-alloys at the extreme pressures and temperatures of the deep Earth. The underlying physical phenomena that would render carbon less siderophile at extreme conditions remain elusive. Here we describe the compaction mechanisms and structural evolution of a simple carbonate glass to deep mantle pressures by monitoring the evolution of the electronic state and atomic structure of the glass upon compression. Our new experiments demonstrate a pressure-induced change in hybridization of carbon from sp2 to sp3 starting at 40 GPa, due to the conversion of [3]CO32- groups into [4]CO44- units, which is completed at ~112 GPa. The pressure-induced increase of carbon coordination number from three to four increases possibilities for carbon-oxygen interactions with lower mantle silicates and increased compatibility4,5. Tetracarbonate melts provide a mechanism for changing the presumed siderophile nature of deep carbon and instead imply storage of carbon in the deep mantle as a possible source for carbon-rich emissions registered at the surface in intra-plate and near-ridge hot spots6,7
qRT-PCR-based DNA homologous recombination associated 4-gene score predicts pathologic complete response to platinum-based neoadjuvant chemotherapy in triple-negative breast cancer
Authors: Zuo Ke , Yuan Xiaoying , Liang Xizi , Sun Xiangjie , Liu Shujin , Connell Philip p. , Li Xingmin , Yang Wentao 
Published: May 2021

Abstract
PurposeCumulative evidences suggested the addition of platinum agents as neoadjuvant chemotherapy (NACT) could improve pathologic complete response (pCR) in triple-negative breast cancers (TNBC). We tried to develop a DNA homologous recombination (HR) associated gene expression score to predict tumor sensitivity to platinum-based NACT in TNBC.MethodsA retrospective cohort of 127 TNBC patients, who were diagnosed and received platinum-based NACT in Fudan University Shanghai Cancer Center from 2012 to 2017, was included in this study. By using quantitative reverse transcription-polymerase chain reaction (qRT-PCR), the expression level of eight HR associated genes was analyzed from the formalin-fixed paraffin-embedded core needle biopsy samples which obtained before NACT. A random forest model was built to estimate the weight of each gene expression level and clinical-pathological factors. The training set was used to modulate parameters and select the best model. The performance of the final model was evaluated in the validation set. ResultsA 4-gene (BRCA1, XRCC5, PARP1, RAD51) expression scoring system was developed. TNBC with higher score had nearly quadruple likelihood to achieve pCR to platinum-based NACT compared with a lower score [odds ratio (OR)=3.878; P<0.001]. At the cut-off value of -2.644, the 4-gene score system showed high sensitivity in predicting pCR in breast (93.0%) and pCR in both breast/axilla (91.8%), while, at the cut-off value of -1.969, the 4-gene score showed high specificity for pCR in breast (85.7%) and pCR in both breast/axilla (80.8%). ConclusionThe qRT-PCR-based 4-gene score has the potential to predict pCR to platinum-based NACT in TNBC.
Assessing the performance of 33 CMIP6 models in simulating the large-scale environmental fields of tropical cyclones
Authors: Han Ying , Zhang Mengzhuo , Xu Zhongfeng , Guo Weidong 
Published: May 2021

Abstract
General circulation model (GCM) biases are one of the important sources of biases and uncertainty in dynamic downscaling–based simulations. The ability of regional climate models to simulate tropical cyclones (TCs) is strongly affected by the ability of GCMs to simulate the large-scale environmental field. Thus, in this work, we employ a recently developed multivariable integrated evaluation method to assess the performance of 33 CMIP6 (phase 6 of the Coupled Model Intercomparison Project) models in simulating multiple fields. The CMIP6 models are quantitatively evaluated against two reanalysis datasets over five ocean areas. The results show that most of the CMIP6 models overestimate the mid-level humidity in almost all tropical oceans. The multi-model ensemble mean overestimates the vertical shear of the horizontal winds in the Northeast Pacific and North Atlantic. An increase in model horizontal resolution appears to be helpful in improving the model simulations. For example, there are 6–8 models with higher resolution among the top 10 models in terms of overall model performance in simulating the climatology and interannual variability of multiple variables. Similarly, there are 7–8 models with lower resolution among the bottom 10 patterns. The model skill varies depending on the region and variable being evaluated. Although no model performs best in all regions and for all variables, some models do show relatively good capability in simulating the large-scale environmental field of TCs. For example, the MPI-ESM1-2-LR, MPI-ESM1-2-HR, and FIO-ESM-2-0 models show relatively good skill in simulating the climatology and interannual variability of the large-scale environmental field in the Northern and Southern Hemispheres.
Construction and Demolition Waste As Recycled Aggregate for Environmentally-Friendly Concrete Paving.
Authors: Llanes Manuel Contreras , Pérez Maximina Romero , González Manuel Jesús Gázquez , Raya Juan Pedro Bolívar 
Published: May 2021

Abstract
Recycled aggregates (RA) from construction and demolition waste (CDW) instead of natural aggregates (NA) was analysed in the manufacture of new eco-friendly concrete. Fine (FRA) and coarse (CRA) recycled aggregates were used in different percentages as substitutes of natural sand and gravel, respectively. The results revealed that the use of RA in percentages of up to 50 wt.% are feasible. Additionally, RA were used to produce paving blocks in accordance with industrial requirements. Thus, values of water absorption lesser than 6% and tensile strength upper than 3.6 MPa were obtained, which are similar to those of a reference sample. These results were achieved by reducing the incorporation of cement, thereby saving production costs and minimizing environmental impact.
Conflict or Coordination? Assessment of Coordinated Development between Socioeconomic and Ecological Environment in Resource-based Cities ： Evidence from Sichuan Province of China
Authors: Xiao Yi , Li Yuan , Huang Huan 
Published: May 2021

Abstract
The relationship between socioeconomic and ecological environment become a significant factor influencing the sustainable development of resource-based cities (RBCs), the transformation of RBCs is a key component of regional high-quality development. A comprehensive evaluation indicator system was constructed to research the coupling coordination level of RBCs in this paper, the dynamic DM model and the CCD model were adopted to measure the comprehensive level of the coupling coordination degree between socioeconomic and ecological environment of the 9 resource-based cities in Sichuan province. The results showed that the coupling coordination level was not ideal. Only two cities were located to the moderate coordination, and other cities were located to the primary coordination or tiny coordination. In addition, there was a significant different between SE and EE, and the comprehensive evaluation score of SE was lower than that of EE in eight RBCs, which accounting for 88.89%. Based on this, the policy suggestions for the sustainable development of different type of RBCs were provided. This study offers a model of China’s experience that might be benefit for achieving sustainable development goals (SGDs) of other cities and countries.