bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of MCP-1 in the development of tubulointerstitial fibrosis in patients with primary chronic glomerulonephritis
Authors: Mukhtarova A. V. , Batyushin M. M. , Sinelnik Е. А. , Antipova N. V. 
Published: September 2021

BACKGROUND.To date, the study of the factors involved in the glomerular-tubular pathological connections leading to damage to the tubulointerstitial tissue is one of the topical areas of nephrology. THE AIM: to study the effect of MCP-1 in the development of tubulointerstitial fibrosis as a factor in the irreversible progression of chronic renal failure. PATIENTS ANDMETHODS.Prospective observation and retrospective analysis of case histories were carried out, which included a total of 75 patients with primary chronic glomerulonephritis. RESULTS.The average age of the patients was 36.7 ± 12.3 years, of which 52 were males, 23 were women. The average length of service in a nephrological disease was 3.0 [1.0; 5.0] years. The calculated GFR values are 87.3 ± 31.2 ml / min / 1.73 m2. In the general population, the moderate degree of MCP-1 expression, estimated at 2 points, was 35 %, pronounced expression was found in 25 % of the respondents. In the mesangium of the glomeruli and in macrophages, the expressed degree of MCP-1 expression was 20 % and 16 %, respectively, which characterizes MCP-1 as a marker produced by resident cells. When studying the relationship of MCP-1 in blood with clinical parameters, a correlation was found with the values of total protein (Rs= –0.43; p <0.05), with erythrocyturia (Rs= –0.28; p <0.05), as well as with an albumin level (Rs= –0.5; p <0.05), which indicates the role of MCP-1 in the development of nephritic forms of glomerulonephritis. Depending on the severity of MCP-1 expression in biopsy specimens, the incidence of focal tubulointerstitial fibrosis with MCP-1 expression estimated at 1 point was 13.3 %, 2 points – 14.3 %, 3 points – 44.0 %. The revealed significant correlation between the serum level of MCP-1 and the severity of tubulointerstitial fibrosis confirms the MCP-1-mediated mechanism of progression of CKD. CONCLUSION.The relationship of serum and tissue forms of MCP-1 with the progression of tubulointerstitial fibrosis in chronic glomerulonephritis has been demonstrated. MCP-1-induced mesangial cell plays a critical role in the development of renal tubular damage, and its increased expression is associated with progressive tubulointerstitial fibrosis and decreased renal function.
Pengaruh Gaya Kepemimpinan Terhadap Kinerja Karyawan Pada Depot Nanda di Kota Bekasi
Authors: Parantoro Apri 
Published: August 2021

The purpose of this study was to determine how much influence and the relationship between leadership style and employee performance. The data collected through a sample to represent the entire population and data collection using a questionnaire. The method used is descriptive method with data collection through questionnaires and observations. The T test results show a significant effect of leadership style on employee performance, it is proven that the variable (X) leadership style and variable (Y) employee performance have a significant value of 0.00 less than 0.05, so it is concluded that the hypothesis is accepted with significantly strong.
Abstrak
Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar pengaruh dan hubungan antara gaya kepemimpinan dengan kinerja pegawai. Data dikumpulkan melalui sampel untuk mewakili seluruh populasi dan pengumpulan data menggunakan kuesioner. Metode yang digunakan adalah metode deskriptif dengan pengumpulan data melalui angket dan observasi. Hasil uji T menunjukkan adanya pengaruh yang signifikan gaya kepemimpinan terhadap kinerja karyawan, terbukti bahwa variabel (X) gaya kepemimpinan dan variabel (Y) kinerja karyawan memiliki nilai signifikansi 0,00 lebih kecil dari 0,05, sehingga disimpulkan hipotesis diterima dengan sangat kuat.
Pelatihan Bola Voli Tingkat Desa
Authors: Iskandar Dedi , Ramadan Gilang 
Published: August 2021

Tujuan pengabdian kepada masyarakat ini untuk meningkatkan kemampuan mingkatan kemampuan permainan pemain bola voli bagi para pemain bola voli di Desa Cimenga Kab. Kuningan Jawa Barat. Metode pelaksanaan dengan menggunakan pelatihan yang digabungkan antara teori dan praktik bagi para peserta. Hasil dari pengabdian ini pada dasaranya masayarakat Desa Cimenga sudah memiliki kemampunan teknik dasar permainan bola voli sangat baik 75% namun 15% di anatara masih katagori cukup dan 10% dibawah rata-rata pemain voli. Kesimpulan dari pengabdian ini adalah sangatlah penting untuk pemahaman para pemain untuk dapat meningkatkan kemampuan bermain bola volinya agar dapat meraih prestasi di bola voli
Ideology and State Apparatus to Create New Order State Power
Authors: Sianipar Jonah Silas 
Published: August 2021

AbstractThis research tries to describe how the New Order State Journey to power and perpetuates its power. By applying Althusser's theory of State Apparatus, this study specifically focuses on the concept of Ideological State Apparatuses (ISA) and Repressive State Apparatuses (RSA) which were operationalized in the New Order society. Qualitative descriptive research is used to interpret data in books that have researched the “New Order” before. The results of this study indicate that the “New Order” state used ISAs such as political parties, cultural, law, media, and religion. Then, “New Order” state used the RSA such as military and para-military organizations to control and maintain domination within the Indonesian State.Keywords: New Order State, Ideological, State ApparatusAbstrakPenelitian ini mencoba mendeskripsikan bagaimana Perjalanan Negara Orde Baru berkuasa dan melanggengkan kekuasaannya. Dengan menerapkan teori Althusser tentang Aparatur Negara, penelitian ini secara khusus berfokus pada konsep Aparatus Ideologi Negara (ISA) dan Aparatur Negara Represif (RSA) yang dioperasionalkan dalam masyarakat Orde Baru. Penelitian deskriptif kualitatif digunakan untuk menafsirkan data dalam buku-buku yang pernah diteliti “Orde Baru” sebelumnya. Hasil penelitian ini menunjukkan bahwa negara “Orde Baru” menggunakan ISA seperti partai politik, budaya, hukum, media, dan agama. Kemudian, negara “Orde Baru” menggunakan RSA seperti organisasi militer dan paramiliter untuk mengontrol dan mempertahankan dominasi di dalam Negara Indonesia.Kata Kunci: Negara Orde Baru, Ideologi, State Apparatus
The Effect of Oketani Breast Massage on Successful Breastfeeding, Mothers’ Need for Breastfeeding Support, and Breastfeeding Self-Efficacy: an Experimental Study
Authors: Mahdizadeh-Shahri, MSc Maryam , Nourian, PhD Manijeh , Varzeshnejad, PhD Maryam , Nasiri, PhD Maliheh 
Published: September 2021

Background: The negative effects of cesarean section on breastfeeding are a major global concern.
Purpose: This study aimed to determine the effect of Oketani breast massage on the maternal need for support during breastfeeding, breastfeeding success, and breastfeeding self-efficacy.
Setting: Three hospitals affiliated to Shahid Beheshti University of Medical Sciences in Tehran, Iran, from April to July 2019.
Study Design: The participants in this experimental study were 113 pregnant women who were candidates for cesarean section. The mothers were selected using convenience sampling and randomly assigned. In addition to routine care, the mothers in the intervention group received Oketani breast massages twice. However, the mothers in the control group received routine care. The data were collected using the Infant Breastfeeding Assessment Tool (IBFAT), LATCH Assessment Score, and the Breastfeeding Self-Efficacy Scale (BSES). The data were analyzed with SPSS 20 software via the independent samples t test, the Mann–Whitney U test, and the chi-square test.
Results: The results of the study suggested that the breastfeeding success rate, which was evaluated with IBFAT in both the first two breastfeeding stages and the last pre-discharge breastfeeding, was significantly higher for the mothers in the intervention group (p < .001). In addition, the mother’s need for support, which was evaluated with LATCH in the first two breastfeeding stages (p = .044) and the last pre-discharge breastfeeding (p < .001) in the intervention group, was less. The total number of breastfeeding sessions from birth to discharge was higher in the intervention group (p = .002). Furthermore, the mothers in the intervention group breastfed their infants in a significantly shorter time interval (p = .002). Breastfeeding self-efficacy, according to the BSES, was significantly higher in the mothers of the intervention group (p < .001).
Conclusion: Oketani massage can be used as a care intervention by nurses to improve breastfeeding in mothers who undergo cesarean sections.
Le burn-out à l’épreuve de la psychanalyse
Authors: Assoun Paul-Laurent 
Published: September 2021

La métaphore du burn-out s’est imposée dans le discours médico-social : notion produite par la psychologie sociale, avec la bénédiction d’une certaine psychanalyse (Freudenberger) dans les années 7, elle s’est popularisée jusqu’à entrer dans le vocabulaire du vécu social. Elle dit l’implosion du sujet sous l’effet du « surmenage » et du stress et dès lors fait ritournelle. Signe du malaise de la culture, la notion exige d’être déconstruite au moyen d’une explicitation métapsychologique et clinique. Originairement pathologie du bénévolat, montrant de jeunes psychothérapeutes « carbonisés » par leur désir salvateur, elle met sur la piste de l’épuisement par la demande de l’Autre. Elle atteste ensuite la version mortifère d’un surmoi mortifère sinistré par son propre pousse-à-l’idéal qui va jusqu’à la promotion pathogène, voire à l’auto-destruction professionnelle
Long-term outcomes of blebs repaired with scleral patch graft and conjunctival advancement in late-onset leak post-trabeculectomy
Authors: Pathak Ray Vanita , Badakere Swathi V 
Published: September 2021

Purpose:
To report long-term outcomes in eyes that developed late-onset bleb leak post trabeculectomy, with or without hypotony and/or maculopathy, due to a scleral melt/fistula and who required a scleral patch graft and conjunctival advancement for repair.

Methods:
Retrospective, non-comparative, interventional case series over a decade (2010–2019), presenting with late bleb leak post-filtration-surgery. All cases required a scleral patch graft and conjunctival advancement for management via a standard technique, performed by an experienced glaucoma surgeon.

Results:
A total of 18 eyes were included. Mean age was 51.5 ± 10.2 years (95% CI [46.4–56.7]) and were followed up after repair for 52.4 ± 26.9 months, 95%CI [39.1–65.8]. 66.7% eyes (n = 12) had IOP ≦6 mmHg and also had hypotony maculopathy. None of the eyes presented with blebitis. 44.5% (n = 8) eyes underwent phacoemulsification as significant cataract was present. LogMAR best-corrected visual acuity (BCVA) was 0.8 ± 0.7 (95% CI [0.4–1.1]) prior to intervention and improved to 0.4 ± 0.6 (95% CI[0.1–0.6], P = 0.004). 22.3% (n = 4) eyes had persistent choroidal folds but BCVA was improved. Mean pre-intervention intraocular pressure (IOP) was 6.3 ± 3.8 mmHg (95% CI 4.4–8.2]) which increased to 12.1 ± 2.9 mmHg (95%CI[10.6–13.5], (P < 0.001). 27.8% (n = 5) eyes needed laser suture lysis post repair to control IOP; two needed further surgical intervention. Number of anti-glaucoma medications at last follow-up was 0.4 ± 0.9 (95% CI [−0.1–0.8], P = 0.09). No serious complications were encountered.

Conclusion:
Scleral patch graft and conjunctival advancement is a useful technique for repair of a scleral fistula post-filtering surgery, and this is recommended not only for the restoration of anatomy for prevention of infection and control of IOP, but also for visual rehabilitation.
Surgical outcomes and complications of sutureless needle-guided intrascleral intraocular lens fixation combined with vitrectomy
Authors: Shelke Komal , Rishi Ekta , Rishi Pukhraj 
Published: September 2021

Purpose:
To analyze the surgical outcomes and complications of sutureless needle-guided intrascleral intraocular lens (IOL) implantation (Yamane technique) combined with pars plana vitrectomy.

Methods:
Retrospective study of 47 eyes of 46 patients that underwent scleral fixation of IOL by the Yamane technique combined with 3-port pars plana vitrectomy. Demographic data, primary indications for surgery, history of trauma, best corrected visual acuity (BCVA), intraocular pressure (IOP), duration of follow-up, and complications were analyzed.

Results:
Mean preoperative BCVA was 0.79 logMAR, which improved to 0.39 logMAR at mean 4.21 months (SD: 4.87 D) follow-up. Mean spherical equivalent pre and postoperative was + 7.64 D (SD: 7.74 D) and − 0.47 D (SD: 2.26 D), respectively. Early postoperative complications included hypotony with cyclodialysis cleft (n = 1; 2%), mild vitreous hemorrhage (n = 2; 4%), raised IOP (n = 2; 4%), and transient corneal edema (n = 2; 4%). Late complications included iris optic capture (n = 1; 2%), retinal detachment (n = 1; 2%), cystoid macular edema (CME; n = 2; 4%), IOL decentration (n = 1; 2%), and decentration and tilting of IOL (n = 1; 2%). Management of complications included laser treatment to cyclodialysis cleft, observation for vitreous hemorrhage, topical and oral IOP lowering agents for raised IOP. CME was managed with topical non-steroidal anti-inflammatory drugs. One eye was subjected IOL refixation. The mean number of surgeries per eye was 1.04.

Conclusion:
Combining needle-guided intrascleral IOL implantation with vitrectomy allows management of other posterior segment complications in the same sitting while obviating the need for the second surgery. It provides satisfactory outcomes that are comparable to published studies. However, a longer follow-up will allow a better understanding of the potential advantages of this approach.
Crossover randomized study comparing the efficacy and tolerability of preservative-free Tafluprost 0.0015% to Latanoprost 0.005% in patients with primary open-angle glaucoma
Authors: Hagras Sherein M , Al-Duwailah Omar KH , Nassief Mona A , Abdelhameed Ameera G 
Published: September 2021

Purpose:
To compare the efficacy and the tolerability of preservative-free Tafluprost 0.0015% (TP) vs Latanoprost 0.005% (LP) in patients with primary open-angle glaucoma (POAG).

Methods:
Prospective, randomized, crossover study included patients with early POAG attending the outpatient clinic from July 2019 to February 2020. Patients were divided into 2 groups: group A included patients receiving TP and group B receiving LP. After 2 months, treatment was stopped for 1 month (washout period) then drops were switched between the groups for further 2 months. Intraocular pressure (IOP) was recorded at baseline and monthly until 5 months. Efficacy was measured by the IOP reduction at the end of each treatment period. Tolerability was assessed both subjectively (questionnaire on ocular comfort) and objectively (ocular findings) at the end of each period.

Results:
A total of 30 patients were allocated into two groups (15 patients each). There was no statistically significant difference between the 2 groups in baseline clinical examinations. All the eyes in both groups achieved IOP reduction >20% compared to baseline values, with no statistically significant difference in between. Corneal erosions and conjunctival hyperemia were significantly higher in LP-treated eyes throughout the study, regardless of the sequence. Tear break-up time scores significantly worsened after LP at the 2nd and 5th month (P < 0.001and P = 0.026 respectively) but not after TP treatment (P = 0.719 and P = 0.164). Significant exacerbation in all patients’ symptoms was noticed on switching from TP to LP.

Conclusion:
Tafluprost was proved to exhibit a comparable effect on IOP control in POAG patients, as Latanoprost drops resulted in marked alleviation in both subjective and objective ocular discomfort manifestations.
Segmented retinal analysis in pituitary adenoma with chiasmal compression: A prospective comparative study
Authors: Agarwal Rachna , Jain Vaibhav K , Singh Shalini , Charlotte Akshata , Kanaujia Vikas , Mishra Prabhakar , Sharma Kumudini 
Published: September 2021

Purpose:
The aim of this study was to determine the alteration in ganglion cell complex and its relationship with retinal nerve fiber layer (RNFL) thickness as measured by spectral-domain optical coherence tomography (OCT) in pituitary adenoma cases and also its correlation with visual field (VF).

Methods:
This is a prospective comparative study wherein detailed neuro-ophthalmic examination including perimetry, RNFL and ganglion cell layer inner plexiform layer (GCL-IPL) thickness were measured preoperatively in the cases of pituitary adenoma with chiasmal compression with visual symptoms and field changes who were planned for neuro-surgical intervention. These parameters were repeated 1 year after the surgery. GCL-IPL, RNFL parameters were compared with controls and were correlated with VF mean deviation (MD). The diagnostic power of GCL-IPL was tested using the receiver operating characteristic (ROC) curve. Healthy age and sex-matched controls without any ocular and systemic abnormality were taken for comparison.

Results:
Twenty-four patients qualified the inclusion criteria. A significant thinning of GCL-IPL (P = 0.002) and RNFL (P = 0.039) was noticed in the pituitary adenoma group. GCL-IPL (r = 0.780 P < 0.001) and RNFL (r = 0.669, P < 0.001) were significantly correlated with the MD. The ROC curve values of GCL-IPL were 0.859 (95% confidence interval 0.744% to 0.973) and of RNFL were 0.731 (95% confidence interval 0.585–0.877). The diagnostic ability of GCL-IPL was more as compared to the RNFL analysis, although it was statistically insignificant (P = 0.122).

Conclusion:
GCL-IPL measurements on the OCT are a sensitive tool to detect early anterior visual pathway changes in chiasmal compression for pituitary adenoma patients.
A cross-sectional study to determine the normal corneal epithelial thickness in Indian population using 9-mm wide optical coherence tomography scans
Authors: Hoshing Abhishek A , Bhosale Seema , Samant Monica P , Bamne Aditya , Kalyankar Huma 
Published: September 2021

Purpose:
To study the corneal epithelial thickness with 9-mm scans of optical coherence tomography in normal Indians with appropriate representation of all age groups.

Methods:
This was a cross-sectional observational study. 263 patients were divided into the age groups 5–20 years, 21–35 years, 36–50 years and more than 51 years were recruited for the study. All patients underwent a detailed ophthalmic examination. Patients found to have any ocular surface or intraocular disease condition (except cataract and refractive error), or who had undergone any ophthalmic surgery in the past, or had corneal topography changes suggestive of corneal ectasias (screened in patients with astigmatism more than 3 diopters) or had been continuously using any topical medication in either eye for a period of 3 months or more with the last instillation being within 1 month of inclusion in the study were excluded. All subjects underwent corneal epithelial thickness measurement with anterior segment optical coherence tomography (AS-OCT) on the Avanti OCT (Model RTVueXR1002, Optovue, USA). The corneal epithelial thickness (CET) data from 25 sectors in each eye were analyzed.

Results:
263 right and left eyes of 263 patients were analyzed in the study. Mean CETs in the central 2 mm zone were 54.13 ± 4.51 μm and 54.37 ± 3.75 μm for the right and left eyes, respectively. The superior peripheral sectors and inferior paracentral sectors were the thinnest and the thickest sectors, respectively, in both eyes.

Conclusion:
CET parameters for Indian eyes are comparable to those reported from racially distinct and geographically distant study subjects.
A simple surgical technique for splitting a single donor cornea for performing deep anterior lamellar keratoplasty and Descemet membrane endothelial keratoplasty without using a microkeratome
Authors: Siddharthan K S , Agrawal Anushri , Reddy Jagdeesh Kumar 
Published: September 2021

Purpose:
To describe a simple manual surgical technique for splitting a single-donor eye for performing both deep anterior lamellar keratoplasty (DALK) and Descemet membrane endothelial keratoplasty (DMEK) without using a microkeratome.

Methods:
Twenty-three eyes with anterior stromal pathology and 23 eyes with irreversible endothelial dysfunction were evaluated for keratoplasty at a tertiary eye care referral center. Twenty-three healthy donor corneas were split into two parts. The Descemet’s membrane was stripped and used for DMEK. The stripped stroma was used for DALK. Best-corrected visual acuity (BCVA) of both DALK and DMEK, endothelial cell density, and endothelial cell loss in DMEK were noted at 1-year follow-up, along with any intraoperative or postoperative complications and failures.

Results:
In the DALK group, mean BCVA improved from 1.264 ± 0.25 log Mar preoperatively to 0.355 ± 0.27 log Mar at 12 months follow-up. There were no complications and failures. In the DMEK group, mean BCVA improved from 1.537 ± 0.61 log Mar preoperatively to 0.592 ± 0.67 log Mar and the mean donor ECD was 3071.66 (range, 2783–3487) cells/mm2 preoperatively, which was reduced to 1989.33 (range, 1546–2543) cells/mm2 at 12 months follow-up indicating a mean endothelial cell loss of 35%. The failure rate was 21.7%.

Conclusion:
This study demonstrates that with a single donor corneal tissue, both DALK and DMEK can be performed successfully without any complications. Our technique will help corneal surgeons in all developing countries to cost effectively perform more lamellar surgeries and help in reducing the magnitude of corneal blindness without the need for expensive microkeratomes.
Health-seeking behavior and the initial economic impact of patients with open globe injuries seeking treatment in a tertiary care center in India
Authors: Prajna Meera Lakshmi , Saxena Ankur , Balasubramanian Ashwin 
Published: September 2021

Purpose:
The aim of this study was to assess the health-seeking behavior and the costs of primary treatment in the immediate aftermath of open globe trauma among patients seeking care at a tertiary eye care center in South India.

Methods:
This prospective observational study was carried out from June to December 2019. Details of the patient’s demographic profile, health-seeking behavior immediately following the trauma and total cost incurred till the completion of primary treatment were collected.

Results:
Eighty-five patients were recruited. Majority of patients were men (53, 82.8%), came from rural areas (65, 76.4%) and were the main breadwinners (44, 68%) of their family. After the initial trauma, a vast majority of the patients (68, 80%) visited the nearest eye care provider to obtain treatment and a majority of them (47, 69.1%) reached there within 3 h. The remaining patients (17, 20%) came directly to our center, the base hospital (BH). The mean distance travelled to the BH was 113.6 km. The mean total cost incurred was INR 20107.6 ± 10441.3. Approximately 84.8% of the patients reported a monthly income less than this amount.

Conclusion:
The economic impact of receiving primary definitive care following open globe injuries is higher than the average monthly income of more than 2/3rd of the patients. To replicate the success stories like the cataract outreach programs, there is a need to implement an integrated program encompassing workplace safety, legal protection to primary eye care providers and providing economic support for definitive treatment for the vulnerable population.