bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Mononuclear Metal Complexes Based on 3‐Acetyl‐4‐Hydroxy Coumarin as Potential Antitumor Agents: Full Structural Elucidation, Theoretical Calculations, and Biological Activity Studies
Authors: Fouad R. , Saif M. , Mashaly Mahmoud M. , Zekrallah M. 
Published: December 2024

ABSTRACTNew transition metal complexes (M‐AHyC) have been prepared: M = Ni2+, Co2+, and Zn2+ metal ions; AHyC = 3‐acetyl‐4‐hydroxy coumarin. The synthesized complexes (M‐AHyC) were also subjected to elemental and TGA analysis, magnetic moment, and molar conductivity measurements with comprehensive spectral characterization (Fourier transform‐IR, UV‐visible, NMR, and XR diffraction). Ni2+, Co2+, and Zn2+ metal ions react with AHyC to form complexes with a stoichiometric ratio 1:2 (M:L). The results of spectral data revealed that the AHyC coordinated the central metal ions in a monoanionic bidentate manner via the carbonyl oxygen and phenolic oxygen atoms forming octahedral geometry. Against HepG‐2 cell lines, the cytotoxic properties of fabricated M‐AHyC compounds were assessed. The cytotoxic study revealed that the Zn‐AHyC complex showed significant activity to inhibit the growth of the HepG‐2 cell line. Additionally, the binding properties of M‐AHyC complexes with herring sperm DNA (HS‐DNA) have been identified using UV‐visible spectroscopy. The interaction between M‐AHyC complexes and DNA revealed a moderately strong interaction depending on the intercalative binding mode. The interaction of M‐AHyC complexes with DNA was further investigated with molecular docking simulation, which supports previously spectroscopic findings. A study on DNA cleavage using agarose gel electrophoresis has also been performed. The DFT calculations were utilized to compute chemical quantum parameters, validate the proposed structures, and provide evidence for the biological findings.
Dot‐by‐Dot Printing of Capacitors by Lift
Authors: Lux Stefan , Kuznetsova Nadezda , Simha Ajeya R. , Mager Dario , Breitling Frank , Korvink Jan G. 
Published: December 2024

ABSTRACTCapacitors play a crucial role in modern electronics as they are widely employed for energy storage, signal processing, radiofrequency tuning and matching, and signal filtering. This paper presents a novel approach to chip‐scale capacitor fabrication utilizing the laser‐induced forward transfer (LIFT) technique, a versatile 3D printing method that offers a flexible and cost‐effective alternative to conventional manufacturing processes. Plate capacitors were fabricated through dot‐by‐dot printing of titanium di‐oxide and silver paste layers, and their performance evaluated. Optimal dot circularity at a diameter of 130 m were achieved with printing parameters of 120 mW for 4 ms, with no noticeable surface defects. Using smaller dots enabled higher resolution, but this compromised the quality of the printed surface. The fabricated capacitors demonstrated a mean capacity of 40.1  2.2 pF at 100 MHz, making them suitable also for high‐frequency applications. The resistivity of the printed silver tracks was , measured over 16 structures, and closely matched the manufacturer's specifications for the silver ink. The achieved resolution from the dot‐by‐dot method used in this paper provided greater flexibility in transfer in comparison to previously reported results using a square‐shaped transfer geometry.
Childhood maltreatment and depression in adult patients: The mediator role of personality functioning
Authors: Vaccarezza Stephanie , Opazo Sebastián , Mundt Adrian P. , Cortázar Alejandra , Errázuriz Paula 
Published: December 2024

AbstractBackgroundChildhood maltreatment (CM), including emotional neglect, physical neglect, emotional abuse, physical abuse and sexual abuse, is associated with an increased risk of adult depression, particularly emotional abuse and neglect. Personality impairment is a significant mediator in the relationship between CM and adult depression.MethodsThis naturalistic cross‐sectional study aimed to examine the mediating role of personality functioning in the association between CM types and depressive symptoms in a clinical sample of adults. We assessed the two dimensions of personality functioning proposed by Section III of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5), specifically self‐functioning and interpersonal functioning. The participants were 335 adult patients starting individual psychotherapy who completed intake self‐report questionnaires to evaluate experiences of CM, personality functioning, depression, and comorbidity of depression and anxiety. Bootstrap mediation analyses were performed to examine the mediating role of personality functioning in the relation between each CM type and depressive symptoms, as well as the comorbidity of depression and anxiety.ResultsPersonality functioning explained half (53%) of the total effect of CM on depressive symptoms and comorbidity. Regarding the different CM types, only the total effects of emotional abuse and neglect on depressive symptoms were significant, evidencing their direct and indirect effect on adult depression. Both personality functioning dimensions were significant mediators, yet self‐functioning had a larger mediating effect, underscoring its critical role.ConclusionsPsychotherapeutic interventions addressing impairments in personality functioning may be crucial in the treatment of depressive symptoms in adult patients with CM.
Identification of Potential Genes in Rheumatoid Arthritis‐Associated Interstitial Lung Disease Using RNA‐seq and In Vitro Analyses
Authors: Nie Liu‐yan , Zhao Kun , Xu Cheng , Zhang Wen‐juan , Huang Xin , Han Yong‐mei 
Published: December 2024

ABSTRACTRheumatoid arthritis‐associated interstitial lung disease (RA‐ILD) is an increasingly recognized extra‐articular manifestations (EAMs) in the RA, with highly morbidity and mortality. The identification of key molecules involved in RA‐ILD has a high requirement in clinic, and the role of their transcriptional regulation in the etiology of RA‐ILD is great significant for investigation. In this study, we collected the whole peripheral blood samples of RA‐ILD and RA only patients to bulk RNA‐sequence. Differential gene expression analysis was employed to identify key genes, common pathways, and potential drug targets for RA‐ILD. Furthermore, RT‐qPCR was conducted to verify potential biomarkers in RA‐ILD. Four hundred seventy‐eight differentially expressed genes (DEGs) were identified that related to chromatin‐modifying enzymes. A robust correlation with immune and inflammation biological processes and pathways was indicated through enrichment analyses of these shared DEGs, like B cell receptor signaling pathway, complement activation, NF‐kappa B signaling pathway. Protein–protein interaction network analysis further emphasized the significance of 12 hub genes, including CHD4, MUS81, CXCL8, NSUN6, RAD9A, CCL4, B3GAT1, KAT2A, TBX21, HDAC2, ERBB2, and ITGAL. Notably, NSUN6 expression was statistically significant in RA‐ILD by the machine learning LASSO regression analysis and RT‐qPCR. Our study provides novel insights into the molecular mechanisms of RA‐ILD, identifies potential biomarkers, and lays the groundwork for future therapeutic strategies.
Fractional Flow Reserve Directed Percutaneous Coronary Intervention Optimization Using High‐Definition Intravascular Ultrasound in Non‐ST‐Segment Elevation Acute Coronary Syndrome Versus Chronic Coronary Syndrome
Authors: Groenland Frederik T. W. , Neleman Tara , Ziedses des Plantes Annemieke C. , Scoccia Alessandra , Kardys Isabella , den Dekker Wijnand K. , Wilschut Jeroen M. , Diletti Roberto , Van Mieghem Nicolas M. , Daemen Joost 
Published: December 2024

ABSTRACTBackgroundIntravascular ultrasound (IVUS)‐guided optimization of suboptimal fractional flow reserve (FFR) following percutaneous coronary intervention (PCI) results in a significant increase in both post‐PCI FFR and minimal lumen and stent areas (MLA and MSA, respectively). However, the impact of clinical presentation with non‐ST‐segment elevation acute coronary syndrome (NSTE‐ACS) versus chronic coronary syndrome (CCS) on the efficacy of PCI optimization remains unknown.MethodsThis was a prespecified subgroup analysis of the FFR REACT trial comparing IVUS‐guided PCI optimization versus no further treatment in 291 patients with a post‐PCI FFR < 0.90. Post‐PCI physiology and pre optimization IVUS findings were compared between patients presenting with NSTE‐ACS versus CCS, as well as optimization strategy, final FFR and IVUS findings.ResultsOut of 291 patients, 130 (44.7%) presented with NSTE‐ACS. Median post‐PCI FFR was similar in patients with NSTE‐ACS and CCS (0.85 for both, p = 0.55). Pre optimization IVUS findings did not differ significantly between both groups and subsequent optimization strategy was comparable (p = 0.71). In both NSTE‐ACS and CCS, optimization resulted in a significant increase (p < 0.01 for all) of similar magnitude in median FFR (0.02 vs. 0.03, p = 0.80), MLA (0.37 vs. 0.50 mm2, p = 0.46) and MSA (0.29 vs. 0.32 mm2, p = 0.61), respectively. The clinical impact of IVUS‐guided optimization on 2‐year target vessel failure showed no signs of heterogeneity based on clinical presentation (interaction p = 0.36).ConclusionsIn patients undergoing FFR‐directed IVUS‐guided optimization, post‐PCI FFR, pre optimization IVUS findings and optimization strategy did not differ significantly between patients presenting with either NSTE‐ACS or CCS, with comparable improvements in FFR, MLA and MSA.
An Oropharyngeal Accessory Tragus in a Young Patient With Conductive Hearing Loss
Authors: Husman Tiffany , Benjamin Tania , Patel Evan J. , Akanuma Naoki , Pigal Anastasiya , Cheng Yew Song 
Published: December 2024

ABSTRACTIn this report, we describe the first reported case of an oropharyngeal accessory tragus in a 20‐year‐old female presenting with moderate to severe left‐sided conductive hearing loss. This case shares rare developmental anomalies to consider when diagnosing oropharyngeal masses that highlight the intricate embryological development of the head and neck region.
Bubble Plume Behavior and Turbulence Characteristics of Gas–Liquid Phase in Power‐Law Fluids
Authors: Dong Xin , Shan Yongrui , Xue Can , Liu Yinuo , Feng Ying , Zhang Jianwei 
Published: December 2024

AbstractThe turbulent characteristics of bubble plumes in power‐law fluids are studied by experiments and numerical simulations. The effects of liquid phase rheological properties and superficial gas velocity on liquid phase velocity, shear stress, turbulent kinetic energy, turbulent scale, and gas holdup of the bubble plume are investigated. The velocity, shear stress, and turbulent kinetic energy of the liquid phase are distributed in a circular pattern during the generation stage, forming stage, and free‐surface interaction stage of the bubble plume. The average shear stress and average turbulence kinetic energy that decomposed turbulent scales in CMC aqueous solution are 31–50 times and 1.4–2 times than that in tap water environment. The gas holdup in the flow field decreases with the increase of concentration of liquid phase and increases with the increase of superficial gas velocity. The flow pattern of the bubble plume is significantly affected by the superficial gas velocity and the rheological properties of the liquid phase that affect the transfer of mass and momentum between phases.
Unique effect of aspirin on local 15‐oxo‐eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity
Authors: Szatkowski Piotr , Gielicz Anna , Stępień Adam , Hartwich Patryk , Kacorzyk Radosław , Plutecka Hanna , Ćmiel Adam , Trąd‐Wójcik Gabriela , Sanak Marek , Mastalerz Lucyna 
Published: December 2024

AbstractBackgroundNonsteroidal anti‐inflammatory drugs–exacerbated respiratory disease (NSAIDs‐ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15‐oxo‐eicosatetraenoic acid (15‐oxo‐ETE), in ISS at baseline and during aspirin‐induced bronchospasm in patients with NSAIDs‐ERD.MethodsOral aspirin challenge was performed in 27 patients with NSAIDs‐ERD and in 17 patients with aspirin‐tolerant asthma (ATA) serving as controls. Sputum was collected before and after aspirin challenge to determine eosinophil, neutrophil, macrophage, and lymphocyte counts as well as the concentration of AA metabolites via 15‐lipoxygenase‐1 (15‐LOX‐1) and 5‐LOX pathways in ISS. Chromatography–tandem mass spectrometry was used to measure ISS levels of 15‐oxo‐ETE, 15‐hydroxyeicosatetranoic acid (15‐HETE), and leukotriene E4 (LTE4).ResultsAt baseline, ISS levels of 15‐oxo‐ETE were higher in NSAIDs‐ERD than in ATA (p = 0.04). In contrast, baseline 15‐HETE levels in ISS were lower in patients with NSAIDs‐ERD (p = 0.03). After aspirin challenge, 15‐oxo‐ETE levels decreased only in patients with NSAIDs‐ERD (p = 0.001) who developed bronchospasm. In both study groups, there was a reduction in sputum macrophage count after aspirin challenge (p = 0.03 and p = 0.02, respectively) irrespective of bronchospasm.ConclusionsPatients with NSAIDs‐ERD are characterized by higher baseline 15‐oxo‐ETE levels in ISS than patients with ATA. Aspirin‐induced bronchospasm inhibited the local generation of 15‐oxo‐ETE.
Fluid–Structure Interaction Analysis of Trapezoidal and Arc‐Shaped Membranes Mimicking the Organ of Corti
Authors: Doi Kentaro , Takeuchi Sho , Yamazaki Hiroki , Tsuji Tetsuro , Kawano Satoyuki 
Published: December 2024

ABSTRACTIn a previous study [H. Shintaku et al., Sensors and Actuators A: Physical 158 (2010): 183–192], an artificially developed auditory sensor device showed a frequency selectivity in the range from 6.6 to 19.8 kHz in air and from 1.4 to 4.9 kHz in liquid. Furthermore, the sensor succeeded in obtaining auditory brain‐stem responses in deafened guinea pigs [T. Inaoka et al., Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 18390–18395]. Since then, several research groups have developed piezoelectric auditory devices that have the capability of acoustic/electric conversion. However, the piezoelectric devices are required to be optimally designed with respect to the frequency range in liquids. In the present study, focusing on the trapezoidal shape of the piezoelectric membrane, the vibration characteristics are numerically and experimentally investigated. In the numerical analysis, solving a three‐dimensional fluid‐structure interaction problem, resonant frequencies of the trapezoidal membrane are evaluated. Herein, Young's modulus of the membrane, which is made of polyvinylidene difluoride and is different from that of bulk, is properly determined to reproduce the experimental results measured in air. Using the modified elastic modulus for the membrane, the vibration modes and resonant frequencies in liquid are in good agreement with experimental results. It is also found that the resonant characteristics of the artificial basilar membrane for guinea pigs are quantitatively reproduced, considering the fluid–structure interaction. The present numerical method predicts experimental results and is available to improve the frequency selectivity of the piezoelectric membranes for artificial cochlear devices.
Low Incidence of Cancer Recorded in the Galapagos Archipelago
Authors: Chisesi Stefano Nicolas , Rugge Massimo , Galli Giulia Raffaella , Manni Martina , Delgado Veronica Mishell Luzuriaga , Chisesi Teodoro , Ruiz Juan Carlos , Briones Rina Mariuxi Quinto , Siculella Luisa , Guzzinati Stefano , Zorzi Manuel , Federico Massimo , Iannone Anna 
Published: December 2024

ABSTRACTBackgroundCancer incidence in the Galapagos archipelago is unknown.AimIn 2021, a task force including Ecuadorian and Italian researchers was established to estimate cancer incidence among the 25 244 Galapagos residents.MethodsRegistration covered all malignancies, including malignant melanoma and non‐melanoma skin cancers; case recording was based on the International Classification of Diseases for Oncology. The data collection involved an active search across all relevant health institutions on the islands and the mainland. Mortality data were obtained from the Ecuador national mortality registry.ResultsFrom January 2013 and December 2019, 174 new cancer cases were recorded, including 134 malignancies (M:F = 58:76) and 40 non‐melanoma skin cancers. The mean age at diagnosis was 48 years for males and 56 years for females. Prostate, gastric, and melanocytic malignancies were most incident among males; breast, thyroid, and cervical cancers prevailed in females. The age‐standardized incidence rates (ASR) were 80.39 for males and 99.24 for females with a mortality‐to‐incidence ratio 0.43. These ASRs were significantly lower than those reported in continental Ecuador and other South American countries.ConclusionsThis pilot cancer registration initiative in the Galapagos record a low incidence of malignancies and requires validation with temporal expansion of cancer registration. The environmental etiology of some of the most common cancers warrants strategic primary and secondary prevention efforts.
Decoding ESG Report Narratives: Unveiling Sustainable Supply Chain Insights and Impacts Through Textual Analysis
Authors: Wang Yicheng , Peng Yingbin , Yang Chen 
Published: December 2024

ABSTRACTThis study explores industry‐specific sustainable supply chain (SSC) practices and their impact on firm value using textual analysis of 4791 ESG reports from S&P 500 companies. A novel SSC dictionary, developed using Word2Vec, highlights variations in SSC practices across eight dimensions—procurement, production, logistics, warehousing, distribution, transportation, retail, and supplier—across different industries. Regression analysis shows that emphasis on procurement and retail SSC practices positively correlates with firm value, with warehousing practices showing marginal significance. The research contributes to SSC literature by introducing a quantitative methodology linking SSC to corporate performance, offering practical insights for aligning supply chain sustainability with profitability.
The Dynamics of Performance Feedback and ESG Disclosure: A Behavioral Theory of the Firm Perspective
Authors: Seow Richard Yeaw Chong 
Published: December 2024

ABSTRACTWhile companies face increasing pressure from stakeholders to enhance their environmental, social, and governance (ESG) transparency, they are continually weighing the benefits and costs of ESG engagements. This study provides a novel exploration of how performance feedback impacts ESG disclosure among Malaysian public‐listed firms, utilizing the behavioral theory of the firm and performance feedback theory. Analyzing data from 72 companies over the period of 2018 to 2022, and employing a fixed effects model with cluster robust errors, the study reveals that firms underperforming relative to their financial aspirations tend to reduce ESG transparency. In contrast, firms that exceed their performance benchmarks show no significant increase in ESG disclosure. These findings underscore the nuanced relationship between financial performance and ESG reporting, offering valuable insights for corporate leaders and policymakers seeking to strengthen ESG frameworks and promote more consistent reporting practices.
ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis
Authors: Chen Ruoxue , Huang Xuan , Hou Jiayun , Ni Junjie , Zhao Wenrui , Li Quanlin , Jiao Heng , Cao Xin 
Published: December 2024

AbstractBackgroudOesophageal cancer ranks among the most prevalent malignant tumours globally, primarily consisting of oesophageal squamous cell carcinoma (ESCC). Cancer stem cells (CSCs) accelerate the progression ESCC via their strong self‐renewal and tumourigenic capabilities, presenting significant clinical challenges due to increased risks of recurrence and drug resistance.MethodsOur previous study has reported WYC‐209, which is capable of inducing apoptosis of CSCs in melanoma and hepatoma, but is ineffective against ESCC. Additionally, clinical studies in ESCC still lack drug candidates that effectively target CSCs. Therefore, our team developed a series of novel retinoids that target retinoic acid receptors (RARs), with enhanced potency, broader efficacy and minimised toxic side effects against CSCs. Following iterative optimisation and pharmacological validation, ZSH‐2208 was identified as the most promising candidate for effectively targeting ESCC tumour‐repopulating cells (TRCs). Mechanistic exploration revealed that ZSH‐2208 inhibits the growth of ESCC‐TRCs through modulation of the RARγ–TNFAIP3 axis. The clinical significance of the key molecule TNFAIP3 in ESCC has also been demonstrated.ResultsThis study introduces ZSH‐2208, a novel retinoid specifically targeting ESCC‐TRCs, which holds significant potential for clinical application in ESCC.Key points
The ESCC‐TRCs replicates the characteristics of ESCC stem cells, which are inhibited by ZSH‐2208.
In vivo and in vitro experiments demonstrated that ZSH‐2208, a novel RA analogue, effectively inhibits the growth of ESCC‐TRCs through the RARγ–TNFAIP3 axis.
Low levels of TNFIP3 protein may be associated with improved survival probability in ESCC patients.
Reduction‐Responsive RGD‐Docetaxel Conjugate: Synthesis, In Vitro Drug Release and In Vitro Antitumor Activity
Authors: Li Qingqing , Liu Yufeng , Cheng Yilin , Cao Huaibao , Du Kunda , Zhu Tianyu , Xu Defeng , Hu Hang 
Published: December 2024

ABSTRACTPoor selectivity to tumor cells is a major drawback in the clinical application of the antitumor drug docetaxel (DTX). Peptide–drug conjugates (PDCs) constructed by modifying antitumor drugs with peptide ligands that have high affinity to certain overexpressed receptors in tumor cells are increasingly assessed for their possibility of tumor‐selective drug delivery. In the present research, DTX is condensed with 3‐(pyridin‐2‐yldisulfanyl) propanoic acid via ester bond to obtain the intermediate Py‐SS‐DTX. Two conjugates GSS‐DTX and RGDC‐SS‐DTX were obtained by conjugation of Py‐SS‐DTX with glutathione (GSH) and RGDC peptide through a thiol‐disulfide exchange reaction. Afterwards, these two peptide–DTX conjugates were characterized by proton nuclear magnetic resonance, Fourier transform infrared spectroscopy, and high‐resolution mass spectrometry. The GSS‐DTX and RGDC‐SS‐DTX were further evaluated in terms of drug release, cell cycle inhibition, cell apoptosis, and cytotoxicity. The results show that both the GSS‐DTX and RGDC‐SS‐DTX exhibit reduction‐responsive drug release and RGDC‐SS‐DTX exhibit higher reduction‐responsiveness. The in vitro antitumor activity study shows that RGDC‐SS‐DTX exhibits enhanced G2/M phase arrest, cell apoptosis rate, and cytotoxicity as compared to GSS‐DTX and free DTX. Besides, RGDC‐SS‐DTX shows reduced cytotoxicity on normal cells as compared to free DTX. The RGDC‐SS‐DTX synthesized in this study represents a novel DTX conjugate to effectively and selectively inhibit tumor cells.