bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveling the field: Development of reliable scoring rubrics for quantitative and qualitative medical education research abstracts
Authors: Jordan Jaime , Hopson Laura R. , Molins Caroline , Bentley Suzanne K. , Deiorio Nicole M. , Santen Sally A. , Yarris Lalena M. , Coates Wendy C. , Gisondi Michael A. 
Published: July 2021

AbstractBackgroundResearch abstracts are submitted for presentation at scientific conferences; however, criteria for judging abstracts are variable. We sought to develop two rigorous abstract scoring rubrics for education research submissions reporting (1) quantitative data and (2) qualitative data and then to collect validity evidence to support score interpretation.MethodsWe used a modified Delphi method to achieve expert consensus for scoring rubric items to optimize content validity. Eight education research experts participated in two separate modified Delphi processes, one to generate quantitative research items and one for qualitative. Modifications were made between rounds based on item scores and expert feedback. Homogeneity of ratings in the Delphi process was calculated using Cronbach's alpha, with increasing homogeneity considered an indication of consensus. Rubrics were piloted by scoring abstracts from 22 quantitative publications fromAEM Education and Training“Critical Appraisal of Emergency Medicine Education Research” (11 highlighted for excellent methodology and 11 that were not) and 10 qualitative publications (five highlighted for excellent methodology and five that were not). Intraclass correlation coefficient (ICC) estimates of reliability were calculated.ResultsEach rubric required three rounds of a modified Delphi process. The resulting quantitative rubric contained nine items: quality of objectives, appropriateness of methods, outcomes, data analysis, generalizability, importance to medical education, innovation, quality of writing, and strength of conclusions (Cronbach's α for the third round = 0.922, ICC for total scores during piloting = 0.893). The resulting qualitative rubric contained seven items: quality of study aims, general methods, data collection, sampling, data analysis, writing quality, and strength of conclusions (Cronbach's α for the third round = 0.913, ICC for the total scores during piloting = 0.788).ConclusionWe developed scoring rubrics to assess quality in quantitative and qualitative medical education research abstracts to aid in selection for presentation at scientific meetings. Our tools demonstrated high reliability.
Data from a public–industry partnership for enhancing corn nitrogen research
Authors: Ransom Curtis J. , Clark Jason , Bean Gregory Mac , Bandura Chris , Shafer Matthew E. , Kitchen Newell R. , Camberato James J. , Carter Paul R. , Ferguson Richard B. , Fernández Fabián , Franzen David W. , Laboski Carrie A.M. , Myers D. Brenton , Nafziger Emerson D. , Sawyer John E. , Shanahan John 
Published: July 2021

AbstractImproving corn (Zeamays L.) N managementis pertinent to economic andenvironmental objectives. However, there are limited comprehensive data sources to develop and test N fertilizer decision aid tools across a wide geographic range of soil and weather scenarios. Therefore, a public‐industry partnership was formed to conduct standardized corn N rate response field studies throughout the U.S. Midwest. This research was conducted using a standardized protocol at 49 site‐years across eight states over the 2014–2016 growing seasons with many soil, plant, and weather related measurements. This note provides the data (found in supplemental files), outlines the data, summarizes key findings, and highlights the strengths and weakness for those who wish to use this dataset.
Understanding consumer attitudes towards ecolabeled food products: A latent class analysis regarding their purchasing motivations
Authors: Grymshi Desjana , Crespo‐Cebada Eva , Elghannam Ahmed , Mesías Francisco J. , Díaz‐Caro Carlos 
Published: July 2021

AbstractEcolabeling is a tool used to promote and support more sustainable products by providing information that enables consumers to select products with better environmental performance. Ecolabels, therefore, can help create social awareness around sustainable consumption and promote respectful attitudes toward the environment, thus generating responsible consumption habits among the consumers. This study aims to analyze the heterogeneity of consumers' motivations in the process of purchasing food products with ecolabels. Additionally, it intends to study consumer typologies regarding their purchasing motivations toward ecolabeled food products to determine possible differences in socioeconomic variables, consumption, and consumer knowledge for these products. To this aim, a total number of 419 questionnaires were collected in Spain during January–February 2019 and a latent class analysis was implemented to segment consumers. The main findings of this study show three types of consumers (indifferent, committed, and skeptical), which present different characteristics, especially regarding their level of knowledge and consumption patterns. [EconLit Citations: M31, O13, Q13, Q56].
Fabrication of phytic acid embellished kaolinite and its effect on the flame retardancy and thermal stability of ethylene vinyl acetate composites
Authors: Zhang Huimin , Meng Dan , Wang Wenjia , Li Hongfei , Gu Xiaoyu , Zhang Sheng , Sun Jun , Xin Fei , Qin Zuodong , Tang Wufei 
Published: July 2021

AbstractA modified kaolinite by grafting with phytic acid (PA‐g‐Kaol) is fabricated, and it was introduced into ethylene vinyl acetate (EVA) with intumescent flame retardancy (IFR) together to improve the flame retardancy of EVA composites. The results show the limiting oxygen index value of EVA/ (18.0 wt% IFR)/ (2.0 wt% PA‐g‐Kaol) is 30.8%. Meanwhile, there is only one dripping produced in the vertical burning test. What's more, the flame‐retardant mechanism is demonstrated by TG‐IR, real‐time‐IR and GC–MS analysis. The results indicate that some pyrolytic products of IFR and PA‐g‐Kaol, like ammonia and phosphoric acid, catalyze the crosslinking of EVA and flame retardant, the resultant compact char protects the substrate from further burning.
Dodecenylsuccinic anhydride modified chitosan hydrogels for the sustained delivery of hydrophobic drugs. The case of thymol buccal delivery
Authors: Alvarez Echazú María I. , Antona María E. , Perna Oriana , Olivetti Christian E. , Alvarez Gisela S. , Macri Elisa V. , Perez Claudio J. , Czerner Marina , Friedman Silvia M. , Desimone Martín F. 
Published: July 2021

AbstractChitosan polymer as a bioactive carrier has an emerging importance due to its great versatility. Many strategies are reported for enhancing its properties. Herein, chitosan hydrogels modified by dodecenylsuccinic anhydride (DDSA) are prepared, characterized by SEM, FTIR, 13C NMR while their mechanical properties and cytotoxicity are assessed. Chitosan modification was studied by FTIR and 13C NMR. According to rheological measurements, modified chitosan hydrogels present a predominantly elastic behavior and exert a higher compressive strength than chitosan hydrogels. Furthermore, this work evaluates thymol incorporation, its release profile as well as its in vivo performance in a periodontitis rat model. In vitro studies reveal that thymol‐loaded‐DDSA‐chitosan hydrogels possess antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa for 2 days and antioxidant activity for 5 days. The incorporation of hydrophobic chains improves thymol release profile; however, DDSA‐chitosan hydrogels cytotoxicity is greater when compared to chitosan hydrogels. Finally, in a preliminary in vivo study, the local application of thymol‐loaded hydrogels is evaluated during a one‐week period. The histomorphometric measurements indicate that periodontal damage is lower when thymol is administrated in chitosan hydrogels in comparison to DDSA‐chitosan hydrogels. Nevertheless, DDSA‐chitosan hydrogels could still be useful for the sustained local delivery of hydrophobic drugs.
The contribution of non‐destructive geophysical surveys to archaeological research of early medieval hillforts in Bohemia: A case study of the Tismice hillfort area
Authors: Krivanek Roman 
Published: July 2021

AbstractGeophysical surveys of different areas of fortified prehistoric or early medieval hillforts are one of the long‐term topics of non‐destructive Czech archaeology. Different stages of geophysical measurements at the site of the early medieval hillfort near Tismice have been carried out under various circumstances of archaeological study in the area. The total full‐area magnetometer survey of all agricultural areas of the hillfort produced new spatial information for subsequent archaeological research of the supra‐regional Slavic centre from before the demise of the Slavník dynasty and the rise of the Přemyslids.
Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort
Authors: Bianchi Matteo , Kozyrev Sergey V. , Notarnicola Antonella , Hultin Rosenberg Lina , Karlsson Åsa , Pucholt Pascal , Rothwell Simon , Alexsson Andrei , Sandling Johanna K. , Andersson Helena , Cooper Robert G. , Padyukov Leonid , Tjärnlund Anna , Dastmalchi Maryam ,   The ImmunoArray Development Consortium,   The DISSECT Consortium, Meadows Jennifer R. S. , Pyndt Diederichsen Louise , Molberg Øyvind , Chinoy Hector , Lamb Janine A. , Rönnblom Lars , Lindblad‐Toh Kerstin , Lundberg Ingrid E. 
Published: July 2021

ObjectiveIdiopathic inflammatory myopathies (IIMs) are a heterogeneous group of complex autoimmune conditions characterized by inflammation in skeletal muscle and extramuscular compartments, and interferon (IFN) system activation. We undertook this study to examine the contribution of genetic variation to disease susceptibility and to identify novel avenues for research in IIMs.MethodsTargeted DNA sequencing was used to mine coding and potentially regulatory single nucleotide variants from ~1,900 immune‐related genes in a Scandinavian case–control cohort of 454 IIM patients and 1,024 healthy controls. Gene‐based aggregate testing, together with rare variant– and gene‐level enrichment analyses, was implemented to explore genotype–phenotype relations.ResultsGene‐based aggregate tests of all variants, including rare variants, identified IFI35 as a potential genetic risk locus for IIMs, suggesting a genetic signature of type I IFN pathway activation. Functional annotation of the IFI35 locus highlighted a regulatory network linked to the skeletal muscle–specific gene PTGES3L, as a potential candidate for IIM pathogenesis. Aggregate genetic associations with AGER and PSMB8 in the major histocompatibility complex locus were detected in the antisynthetase syndrome subgroup, which also showed a less marked genetic signature of the type I IFN pathway. Enrichment analyses indicated a burden of synonymous and noncoding rare variants in IIM patients, suggesting increased disease predisposition associated with these classes of rare variants.ConclusionOur study suggests the contribution of rare genetic variation to disease susceptibility in IIM and specific patient subgroups, and pinpoints genetic associations consistent with previous findings by gene expression profiling. These features highlight genetic profiles that are potentially relevant to disease pathogenesis.
Ligand‐assisted Hydride Transfer: A Pivotal Step for CO2 Hydroboration Catalyzed by a Mononuclear Mn(I) PNP Complex
Authors: Wan Xiang , Li Man , Liao Rong‐Zhen 
Published: July 2021

AbstractA mononuclear Mn(I) pincer complex [Mn(Ph2PCH2SiMe2)2NH(CO)2Br] was disclosed to catalyze the pinacolborane (HBpin)‐based CO2 hydroboration reaction. Density functional calculations were conducted to reveal the reaction mechanism. The calculations showed that the reaction mechanism could be divided into four stages: (1) the addition of HBpin to the unsaturated catalyst C1; (2) the reduction of CO2 to HCOOBpin; (3) the reduction of HCOOBpin to HCHO; (4) the reduction of HCHO to CH3OBpin. The activation of HBpin is the ligand‐assisted addition of HBpin to the unsaturated Mn(I)‐N complex C1 generated by the elimination of HBr from the Mn(I) pincer catalyst. The sequential substrate reductions share a common mechanism, and every hydroboration commences with the nucleophilic attack of the Mn(I)‐H to the electron‐deficient carbon centers. The hydride transfer from Mn(I) to HCOOBpin was found to be the rate‐limiting step for the whole catalytic reaction, with a total barrier of 27.0 kcal/mol, which fits well with the experimental observations at 90 °C. The reactivity trend of CO2, HCOOBpin, HCHO, and CH3OBpin was analyzed through both thermodynamic and kinetic analysis, in the following order, namely HCHO>CO2>HCOOBpin≫CH3OBpin. Importantly, the very high barrier for the reduction of CH3OBpin to form CH4 reconciles with the fact that methane was not observed in this catalytic reaction.
Synthesis of Functionalized Aliphatic Acid Esters via the Generation of Alkyl Radicals from Silylperoxyacetals
Authors: Matsumoto Akira , Shiozaki Yoko , Sakurai Shunya , Maruoka Keiji 
Published: July 2021

AbstractWe describe a catalytic method for the synthesis of a variety of functionalized aliphatic acid esters using silylperoxyacetals, which are versatile alkyl radical precursors with a terminal ester moiety. In the presence of an appropriate transition‐metal catalyst, the in situ generation of alkyl radicals and the subsequent bond‐forming process proceeds smoothly to afford synthetically valuable aliphatic acid derivatives. The present method can be applied to the efficient synthesis of a pharmaceutically important 1,1‐diarylalkane motif. In addition, a novel strategy for the synthesis of structurally diverse hydroxy acid derivatives via a C−O bond formation process that utilizes TEMPO has been developed.
NLTE CNO abundances in a sample of nine field RR Lyr type stars
Authors: Andrievsky Sergei M. , Korotin Sergey A. , Kovtyukh Valery V. , Khrapaty Sergey V. , Rudyak Yuri 
Published: July 2021

AbstractFor the first time, a direct non‐local thermodynamic equilibrium (NLTE) analysis of carbon and nitrogen lines in the spectra of nine RR Lyrae stars was carried out. We have determined the abundances of these elements together with oxygen, and have shown that the nitrogen content is increased in metallicity‐deficient program stars. We conclude that this is a sign of the first dredge up, which occurred at the previous stage of the red giant branch, and brought material processed in an incomplete carbon, nitrogen, oxygen (CNO) cycle to the surface of the star. This effect is significantly enhanced by thermohaline (extra‐) mixing, which is more effective for metal‐poor RR Lyrae stars. This is clearly seen in the plot showing that C/N ration in our sample of stars gradually decreases as metallicity decreases from about −0.2 to −2. Oxygen abundance depends on metallicity in a similar way to what we see in the Population II stars.
Toward conditional control of Smac mimetic activity by RNA‐templated reduction of azidopeptides on PNA or 2′‐OMe‐RNA
Authors: Altrichter Yannic , Schöller Justus , Seitz Oliver 
Published: July 2021

AbstractOligonucleotide templated reactions can be used to control the activity of functional molecules based on the presence of a specific trigger sequence. We report an RNA‐controlled reaction system to conditionally restore the N‐terminal amino group and thus binding affinity of azide‐modified Smac mimetic compounds (SMCs) for their target protein X‐linked Inhibitor of Apoptosis Protein (XIAP). Two templated reactions were compared: Staudinger reduction with phosphines and a photocatalytic reaction with Ru(bpy)2(mcbpy). The latter proved faster and more efficient, especially for the activation of a bivalent SMC, which requires two consecutive reduction steps. The templated reaction proceeds with turnover when 2′‐OMe‐RNA probes are used, but is significantly more efficient with PNA, catalyzing a reaction in the presence of low, substoichiometric amounts (1%‐3%, 10 nM) of target RNA.
Preoperative magnetic resonance imaging criteria for predicting lymph node metastasis in patients with stage IB1‐IIA2 cervical cancer
Authors: He Fangjie , Zu Shuiling , Chen Xia , Liu Jianping , Yi Ying , Yang Haijun , Wang Fuqiang , Yuan Songhua 
Published: July 2021

AbstractObjectiveThis study aimed to identify patients with stage IB1‐IIA2 cervical cancer at low risk for lymph node metastasis (LNM) using preoperative magnetic resonance imaging (MRI) parameters.MethodsClinical and MRI data of patients with stage IB1‐IIA2 cervical cancer who underwent radical surgery between 2010 and 2015 were retrospectively reviewed. Clinical stage IB1‐IIA2 cervical cancer was diagnosed according to the 2009 International Federation of Gynecology and Obstetrics staging system. The low‐risk criteria for LNM were identified using logistic regression analysis. The performance of the logistic regression analysis was estimated through receiver operating characteristic curve analysis.ResultsOf 453 patients, 105 (23.2%) exhibited pathological LNM (p‐LNM). The maximal tumor diameter (adjusted odds ratio [aOR], 1.586; 95% confidence interval [CI], 1.312–1.916; p < 0.001) and LNM (aOR, 2.384; 95% CI, 1.418–4.007; p = 0.001) on preoperative MRI (m‐LNM) were identified as independent risk factors for p‐LNM using a multivariate logistic analysis. The p‐LNM rate was 4.0% for low‐risk patients (n = 124) identified using the current criteria (maximal tumor diameter <3.0 cm and no sign of m‐LNM). The 5‐year disease‐free survival rate of low‐risk patients was significantly greater than the rate of patients with a maximal tumor diameter ˃3.0 cm and/or signs of m‐LNM (90.4% vs. 82.1%; p = 0.033).ConclusionsThe low‐risk criteria for p‐LNM were a maximal tumor diameter <3.0 cm and no sign of m‐LNM. Patients with stage IB1‐IIA2 cervical cancer at low risk for m‐LNM could be candidates for radical surgery; hence, they have a lesser need for adjuvant chemoradiotherapy, thus avoiding the severe comorbidities it causes.
Value priorities of the Finnish farmers—Time to stop thinking of farmers as inherently conservative and traditional
Authors: Sorvali Jaana , Kaseva Janne , Vainio Annukka , Verkasalo Markku , Peltonen‐Sainio Pirjo 
Published: July 2021

AbstractFarming communities are becoming more heterogeneous and multifunctional due to various structural and environmental changes. However, it is not known if farmers' values have also become more heterogeneous. We wanted to explore potential heterogeneity in farmers' value priorities in detail across different farmer groups in Finland using the refined Schwartz theory of 19 basic human values. A representative sample of 4,401 Finnish farmers responded to a survey in 2018. The data were analysed with multidimensional scaling, confirmatory factor analysis and one‐way analysis of variance. The results show that farmers' values were heterogeneous, and differences were associated with socio‐demographic characteristics. Our findings confirmed the motivational continuum structure of values, with the exception of societal‐value. Security‐societal was the most important value for the Finnish farmers. The theory of 19 values proved useful in uncovering value priorities in detail. The security‐societal value is more a part of national identity rather than a personal motivational value in the Finnish farming community. The heterogeneity of farmers' values should be considered in more targeted policy planning.
Purchasing social attention by tipping: Materialism predicts online tipping in live‐streaming platform through self‐enhancement motive
Authors: Wu Yang , Niu Gengfeng , Chen Zhenzhen , Zhang Dongjing 
Published: July 2021

AbstractOnline tipping, or virtual gift‐giving, on live‐streaming platforms is an increasingly common consumer behavior in cyberspace. Perplexingly, when live‐stream viewership itself is free, viewers voluntarily spend money to buy virtual gifts and send them to their preferred streamers. The present study aimed to examine the motivational mechanism underlying these voluntary tipping behaviors from the perspectives of materialism and self‐enhancement. By a representative online survey (N = 1224), we found that participants' materialist beliefs were positively associated with both the likelihood and the amount of online tipping, and the self‐enhancement motive could significantly mediate this association; furthermore, streamer endorsement could moderate the link between the self‐enhancement motive and tipping amount. These findings suggest that materialist beliefs and downstream self‐related motivations are among the main driving forces for online tipping. The present results extended previous research on materialism by testing its effects in a newly emerging online consumer behavior and providing direct evidence for the moderation role of the “symbolic‐ness” of materialist behaviors. Practical implications for live‐streaming platforms, educators and policymakers, such as introducing tipping amount caps, were also discussed.
FBXW7 induces apoptosis in glioblastoma cells by regulating HDAC7
Authors: Nie Xiaohu , Jia Weiqiang , Li Xiaobin , Pan Xuyan , Yin Rui , Liu Ning , Su Zhongzhou 
Published: July 2021

AbstractGlioblastoma is an aggressive type of brain cancer with an extremely poor prognosis. Additionally, the F‐box WD repeat‐containing protein 7 (FBXW7) is a component of the ubiquitin‐proteasome system that has been widely implicated in human cancers. In this study, we investigated the role and mechanism of FBXW7 in glioblastoma. FBXW7 expression was analyzed in normal and glioblastoma tissue samples using The Cancer Genome Atlas Glioblastoma Multiforme (TCGA‐GBM) database. Then, quantitative reverse transcription‐polymerase chain reaction (RT‐PCR) was used to examine mRNA expression, whereas, western blot analysis was conducted to determine protein levels of the samples. Furthermore, cell apoptosis was assessed using the Annexin V staining method, followed by flow cytometry analysis. Immunoprecipitation (IP) assay was conducted as well to test protein–protein interactions. Lastly, protein expression in tissues was examined by conducting immunohistochemistry (IHC). Results showed that the glioblastoma tissue samples displayed an FBXW7 downregulation compared with normal tissues. In vitro, the overexpression of FBXW7 in glioblastoma cells induced apoptosis, whereas, its knockdown displayed the opposite effect. Mechanistically, FBXW7 interacted with HDAC7 to promote HDAC7 ubiquitination, however, the overexpression of HDAC7 in glioblastoma cells blocked FBXW7‐induced apoptosis. Finally, FBXW7 and HDAC7 displayed an inverse correlation in glioblastoma tissues in vivo. Therefore, our data demonstrated an important function of FBXW7 in promoting glioblastoma apoptosis by interacting with HDAC7 and promoting HDAC7 ubiquitination.
Gallstone Ileus with COVID‐19 Infection: An Unintended Sequela of Non‐Operative Management of Acute Cholecystitis During the COVID‐19 Pandemic
Authors: Shah Adil A. , Stewart Shai , Raza Ahmed , Nizam Wasay , Petrosyan Mikael , Williams Mallory , Cornwell Edward E 
Published: July 2021

AbstractAppropriate risk stratification and careful follow‐up are mandated in elderly patients with comorbidities. Herein, we report a case presenting 5 months after the nonoperative management of acute cholecystitis during the height of the COVID‐19 pandemic.
SARS‐CoV‐2 infection in hematological patients during allogenic stem cell transplantation: A double case report
Authors: Alexandra Van Uytvanck , Sebastian Wittnebel , Nathalie Meuleman , Angela Loizidou , Jean‐Corentin Salengros , Chloé Spilleboudt 
Published: July 2021

AbstractDespite severe immunosuppression due to conditioning chemotherapy for acute myeloid leukemia, COVID‐19 did not lead to clinical deterioration or death, thus raising the question of the impact of immunosuppressive treatment on clinical course evolution.