bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of chemoembolization in hepatocellular cancer and metastatic liver damage
Authors: Shakeyev K. , Kabildina N. , Lytkin V. , Zhumakaev A. , Kruk E. , Usembekov B. , Murat A. 
Published: May 2021

Treatment of patients with hepatocellular cancer remains a complex problem in modern oncology.
The purpose was to evaluate the effectiveness of chemoembolization in hepatocellular cancer and metastatic liver disease.
Results: During and after the procedure, the risk of complications was minimal: in 2 cases (0.25%), liver necrosis and death from cardiovascular insufficiency were recorded after five therapy courses. Eleven patients (23.9%) with a continued tumor growth showed a negative response and were administered symptomatic treatment.
Conclusion: In primary hepatocellular cancer and metastatic liver lesions, chemoembolization is one of the priorities in interventional radiology and a stage of complex treatment. This method is low-traumatic due to a minimal toxic effect of the chemotherapy drug. This method is indicated for inoperable liver tumors because a high concentration of an anticancer drug is delivered right to the focus and ensures a prolonged tumor exposure, with minimal risk of complications during and after the procedure. In our observations, complications in the form of necrosis and death occurred in 2 (0.25%) cases.
Kiểu gen và kiểu hình của một số ca bệnh tăng sản thượng thận bẩm sinh thể tích tụ Lipid
Authors: Hà Nguyễn Thu , Dũng Vũ Chí 
Published: May 2021

Tăng sản thượng thận bẩm sinh thể tích tụ lipid (lipoid congenital adrenal hyperplasia – LCAH) là thể bệnh nặngnhất trong các thể của bệnh tăng sản thượng thận bẩm sinh.Nghiên cứu mô tả đặc điểm kiểu hình (biểu hiện lâm sàng, hóa sinh)và kiểu gen của 5 bệnh nhân được chẩn đoán LCAH tại bệnh viện Nhi Trung Ương.Trong nghiên cứu có 2 nữ, 3 nam. 4/5 bệnh nhân có biểu hiện suy thượng thận ngay từ sau đẻ, với biểu hiện sạm da và mất muối. 2/3 bệnh nhân nam có ngoại hình nữ, 1/3 bệnh nhân nam có kiểu hình nam bình thường. Xét nghiệm sinh hoá có nồng độ ACTH tăng cao (5/5 bệnh nhân), hạ Natri máu và tăng Kali máu (4/5 bệnh nhân), trong khi nồng độ 17OHP bình thường hoặc thấp (5/5 bệnh nhân).Phân tích phân tử phát hiện đột biến ở genStARgiúp khẳng định chẩn đoán bệnh tăng sản thượng thận bẩm sinh thể tích tụ lipid – một nguyên nhân hiếm gặp gây suy thượng thận mạn, giúp điều trị hiệu quả và tư vấn di truyền phòng bệnh.
Tình trạng di căn hạch của ung thư tuyến giáp thể biệt hóa ở nam giới
Authors: Hậu Nguyễn Xuân , Long Nguyễn Thanh , Hiền Nguyễn Xuân , Quảng Lê Văn 
Published: May 2021

Nghiên cứu được tiến hành nhằm đánh giá tình trạng di căn hạch trong ung thư tuyến giáp thể biệt hóa ở nam giới tại bệnh viện Đại học Y Hà Nội. Nghiên cứu tiến cứu trên 102 bệnh nhân nam giới ung thư tuyến giáp thể biệt hóa được phẫu thuật tại Bệnh viện Đại học Y Hà Nội từ tháng 7/2018 đến tháng 08/2020. Độ tuổi trung bình là 40,9 ± 13,0 tuổi. Khối u chủ yếu ở 1 thùy (79,4%), kích thước ≤ 1cm (65,7%). Đánh giá trên siêu âm chủ yếu là TIRADS 4 (66,6%), tỉ lệ chọc hút tế bào kim nhỏ chẩn đoán ác tính 74,5%. Đa số các bệnh nhân được phẫu thuật cắt toàn bộ tuyến giáp (67,6%). Tỉ lệ di căn hạch chung là 59,8%, tỉ lệ di căn hạch cổ nhóm 6 đơn thuần và kèm theo hạch cổ bên lần lượt là 56,1% và 33,3%. Tỉ lệ di căn hạch tiềm ẩn là 47,1%. Các yếu tố: kích thước u > 1cm, ung thư hai thùy, u phá vỡ vỏ xâm lấn ra ngoài tuyến liên quan có ý nghĩa thống kê với tình trạng di căn hạch (p < 0,05).
Origin of Magnetite in the Zoned Ultramafic Complexes of Southeastern Alaska1
Authors: Taylor Hugh P. , Noble James A. 
Published: May 2021

Abstract
Appreciable concentrations of titaniferous magnetite occur in several of the ultramafic complexes that are exposed along a linear belt 350 miles in length in southeastern Alaska. Four of the larger bodies, at Klukwan, Snettisham, Union Bay, and Duke Island, are of economic interest. Large magnetite concentrations (15–20 percent of the rock by volume) of very uniform grade occur in the hornblende pyroxenite units of these complexes.
In several of the complexes (including Union Bay and Duke Island) a consistent zoning of ultramafic rock types occurs, with dunite, peridotite, olivine pyroxenite, and hornblende pyroxenite occurring in sequence from the center outward to the margin. Only the hornblende pyroxenite zone is exposed at Klukwan and Snettisham, but the mineralogy of this zone is identical in all the complexes. The minerals are diopsidic augite (Di85Hed15 to Di70Hed30), hornblende (abnormally high in A12O3 and low in SiO2 relative to most igneous hornblendes), magnetite, and accessory ilmenite and hercynitic spinel. Accessory amounts of olivine may occur in the interior parts of the magnetite pyroxenite zones of the complexes that contain olivine pyroxenite and/or dunite, but the magnetite concentrations drop abruptly as the amount of olivine increases; magnetite is largely absent from the olivine pyroxenite zones.
The many common features of these ultramafic bodies indicate that they formed by a single mechanism, namely by crystallization of ultramafic magmas. Evidence for this includes: (1) graded layering in rhythmically-bedded olivine pyroxenite and magnetite pyroxenite; (2) significant contact metasomatism and metamorphism at the margins of the bodies; and (3) good correspondence between observed rock types and experimentally studied liquids in the system diopside-olivine-iron oxide. It is suggested that the complexes formed by a combination of fractional crystallization and multiple intrusion of ultramafic magmas, and that the magnetite-hornblende pyroxenite zones in particular crystallized from a liquid roughly corresponding to their present chemical composition. This liquid must have had a total Fe content of about 15–18 percent by weight.
Management of high-grade renal traumas with collecting system injuries
Authors: Locke Jennifer A. , Neu Sarah , Navaratnam Roshan , Phillips Andrea , Nathens Avery B. , Herschorn Sender , Kodama Ronald 
Published: May 2021

Introduction: Approximately 50% of all high-grade renal traumas (HGRT, American Association for the Surgery of Trauma [AAST] grade 4/5) have associated collecting system injuries. Although most of these collecting system injuries will heal spontaneously, approximately 20–30% of these injuries are managed with ureteric stents. The objective of the study was to review the management of HGRT with collecting system injuries in a level 1 trauma center.
Methods: This was a single-center, retrospective cohort study of trauma patients with HGRT and collecting system injuries from 1998–2019.
Results: We identified 147 patients with HGRT. Of the 105 patients who had trauma computed tomography (CT) imaging within 24 hours, 46 were found to have collecting system injuries. Seven of these patients underwent intervention based on initial CT findings; the remaining 39 patients with urinary extravasation were conservatively managed. Of the 37 patients who underwent reimaging, 22 (59%) demonstrated a stable or resolving collection and 15 (41%) demonstrated continued urinary extravasation. Resolution of extravasation on subsequent imaging was observed in 10 of those patients, while five patients (14%) required intervention (four stents, one percutaneous drain) for symptoms/signs of urinary extravasation.
Conclusions: In this study, most patients with HGRT and collecting system injuries did not require intervention unless the patient became symptomatic. The majority of collecting system injuries resolved with no intervention. This study underscores the need for future prospective trials to investigate the necessity of intervening in HGRT collecting system injuries and, secondarily, the need for routine reimaging in these asymptomatic patients.
De nieuwe juridische jas voor de maatschappelijke onderneming komt eraan: de BVm
Authors: Zillikens-Loos M.J.L.A.M. , Crul Q.M.J.A. , Schriemer T.A. 
Published: May 2021

De nieuwe juridische jas voor de maatschappelijke onderneming komt eraan: de BVm
Het Ministerie van EZK heeft een ‘Aanzet voor een wettelijke regeling voor een besloten vennootschap met maatschappelijk doel (BVm)’ aangeboden ter internetconsultatie. In dat kader gaan auteurs in op de onderdelen van de Aanzet en zetten zij hun opmerkingen en aanbevelingen voor de wettelijke regeling (de BVm-wet) uiteen.
Brain-derived neurotrophic factor increases cell number of neural progenitor cells derived from human induced pluripotent stem cells
Authors: Pansri Panetha , Phanthong Phetcharat , Suthprasertporn Nopparat , Kitiyanant Yindee , Tubsuwan Alisa , Dinnyes Andras , Kobolak Julianna , Kitiyanant Narisorn 
Published: May 2021

BackgroundSeveral pieces of evidence from in vitro studies showed that brain-derived neurotrophic factor (BDNF) promotes proliferation and differentiation of neural stem/progenitor cells (NSCs) into neurons. Moreover, the JAK2 pathway was proposed to be associated with mouse NSC proliferation. BDNF could activate the STAT-3 pathway and induce proliferation in mouse NSCs. However, its effects on proliferation are not fully understood and JAK/STAT pathway was proposed to play a role in this activity.MethodsIn the present study, the effects of BDNF on cell proliferation and neurite outgrowth of Alzheimer’s disease (AD) induced pluripotent stem cells (iPSCs)-derived human neural progenitor cells (hNPCs) were examined. Moreover, a specific signal transduction pathway important in cell proliferation was investigated using a JAK2 inhibitor (AG490) to clarify the role of that pathway.ResultsThe proliferative effect of BDNF was remarkably observed as an increase in Ki-67 positive cells. The cell number of hNPCs was significantly increased after BDNF treatment represented by cellular metabolic activity of the cells measured by MTT assay. This noticeable effect was statistically shown at 20 ng/ml of BDNF treatment. BDNF, however, did not promote neurite outgrowth but increased neuronal cell number. It was found that AG490 suppressed hNPCs proliferation. However, this inhibitor partially decreased BDNF-induced hNPCs proliferation. These results demonstrated the potential role of BDNF for the amelioration of AD through the increase of AD-derived hNPCs number.
Retracing our steps to understand ketamine in depression: A focused review of hypothesized mechanisms of action
Authors: Irwin Madison N. , VandenBerg Amy 
Published: May 2021

AbstractIntroductionMDD represents a significant burden worldwide, and while a number of approved treatments exist, there are high rates of treatment resistance and refractoriness. Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, is a novel, rapid-acting antidepressant, however the mechanisms underlying the efficacy of ketamine are not well understood and many other mechanisms outside of NMDAR antagonism have been postulated based on preclinical data. This focused review aims to present a summary of the proposed mechanisms of action by which ketamine functions in depressive disorders supported by preclinical data and clinical studies in humans.MethodsA literature search was completed using the PubMed and Google Scholar databases. Results were limited to clinical trials and case studies in humans that were published in English. The findings were used to compile this article.ResultsThe antidepressant effects associated with ketamine are mediated via a complex interplay of mechanisms; key steps include NMDAR blockade on γ-aminobutyric acid interneurons, glutamate surge, and subsequent activation and upregulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.DiscussionCoadministration of ketamine for MDD with other psychotropic agents, for example benzodiazepines, may attenuate antidepressant effects. Limited evidence exists for these effects and should be evaluated on a case-by-case basis.
The use of the ketogenic diet in the treatment of psychiatric disorders
Authors: Tillery Erika E. , Ellis Katie D. , Threatt Tiffaney B. , Reyes Hannah A. , Plummer Christopher S. , Barney Logan R. 
Published: May 2021

Abstract

Introduction
The ketogenic diet (KD) is a high-fat, low-carbohydrate, and moderate-protein diet that has shown benefit as a treatment in neurologic disorders and may serve as a therapeutic option in individuals with psychiatric disorders.

Methods
A search was conducted using EBSCOhost and PubMed databases for studies relating to ketogenic or low-carbohydrate diets and psychiatric disorders.

Results
A total of 32 experimental or observational studies were identified by initial search strategies, 14 of which met the criteria to be included in this analysis. Although specific diet formulations varied somewhat between studies, they all generally examined low-carbohydrate dietary intake with the goal of producing a ketotic state. The studies included in this review indicated the KD was beneficial in reducing symptoms associated with various psychiatric disorders.

Discussion
This review summarizes the available evidence regarding the efficacy of the ketogenic diet in psychiatric disease states. Data from the studies analyzed demonstrated a positive response in individuals who were able to remain on the diet, regardless of the disease state. However, there is a need for more data to clearly define the specific benefits the KD may provide.
The opinion of Brazilian women regarding vaginal labor and cesarean section
Authors: Osis M.J.D. , Pádua K.S. , Duarte G.A. , Souza T.R. , Faúndes A. 
Published: July 2002

AbstractObjectives: The opinions of Brazilian women regarding vaginal delivery and cesarean sections was studied. Methods: Six hundred and fifty‐six women who had given birth in seven hospitals in São Paulo and Pernambuco, using the Public Health Service, were interviewed. The opinions of women who had delivered only by cesarean section was compared with those of women who had had at least one vaginal delivery. Results: Significantly more women who had experienced at least one vaginal delivery considered this to be the best way of giving birth (90.4% vs. 75.9% among C‐section‐only women). Similar proportions in both groups (45.5% and 42.8%) stated that vaginal labor is better because it causes less pain and suffering for the woman. Significantly more women who had experienced a vaginal labor (47.1% vs. 30.3%) reported that it had no disadvantage. More women who had only had cesarean sections referred not having contractions/pain as an advantage of this method (56.7% vs. 41.7%). Conclusions: Apparently, pain and women's perception of pain were the characteristics which differentiated women with history of vaginal delivery from those with cesarean sections in the sample studied. However, the opinion that vaginal delivery is better than cesarean section was expressed independently of the recognition that pain could be its main disadvantage.
Serum vitamin K level and bone mineral density in post‐menopausal women
Authors: Kanai T. , Takagi T. , Masuhiro K. , Nakamura M. , Iwata M. , Saji F. 
Published: July 2002

AbstractObjective: Vitamin K is known to influence bone metabolism by facilitating the synthesis of osteocalcin (BGP). The bone mineral density decreases drastically after menopause. We investigated the relationship of bone mineral density, vitamin K levels and other biological parameters of bone metabolism in post‐menopausal women. Methods: Serum levels of vitamin K, BGP and other markers of bone metabolism were measured in 71 post‐menopausal women (19 with reduced bone mineral density and 52 with normal bone density), and 24 women with climacteric symptoms receiving hormone replacement therapy (HRT), (6 with reduced bone mineral density and 18 with normal density). Results: In the first group, women with reduced bone mineral density showed lower levels of vitamin K1 and K2 than those with normal bone mineral density. In the other group, the level of BGP decreased but levels of vitamin K showed no increase during HRT. Conclusion: The present findings suggested that vitamin K was related to post‐menopausal bone mineral loss.
Great grand multiparity: is it a risk?
Authors: Abu‐Heija A.T , El Chalabi H 
Published: July 2002

AbstractObjective: To compare antenatal and intrapartum complications incidence among women delivering for the 10th time or more and to compare this with those of low parity (para 2–5). Methods: The records of (154) women of great grand multipara (para>10) were reviewed and compared with (308) women (para 2–5) delivered during the same period. Antepartum as well as intrapartum complications were compared, all occurring between 16 April 1994 and 15 January 1995. Results: Great grand multiparous women are older. The incidence of diabetes mellitus, chronic hypertension and preterm labor are similar to those with low parity, while they have higher incidences of pre‐eclampsia (7.1% vs. 2.6%) and intrauterine fetal death (5.2 vs. 1.3%) P<0.025. There were no differences in the incidences of placental abruption, placenta previa, malpresentation, postpartum hemorrhage and operative delivery between the two groups. Great grand multipara also have a higher incidence of macrosomia (12% vs.12%) P<0.0001. Conclusion: Great grand multiparous woman are at increased risk of having pre‐eclampsia, intrauterine fetal death and macrosomia.
The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff
Authors: Premdas J. , Tang J.‐B. , Warner J. P. , Murray M. Meaney , Spector M. 
Published: July 2002

AbstractThe rotator cuff frequently sustains athletic and occupational injury, often resulting in chronic pain and disability. However, despite the high incidence of such shoulder problems, the pathophysiology of rotator cuff injury and healing has not yet been fully elucidated. The notable finding of this study was the presence of a contractile actin isoform, α‐smooth muscle actin (SMA), in nonvascular cells in all of the seven torn human rotator cuff specimens evaluated immunohistochemically. Up to 95% of cells in any one region, and over 95% of elongated cells found in association with crimped collagen, contained SMA. Most of the cells staining positive for SMA in these sections had morphological features of the fibroblast, though a small number were chondrocyte‐like. Treatment of cells growing out from human rotator cuff explants with TGF‐β1 significantly increased the amount of SMA evaluated by Western blot analysis. PDGF‐BB and IFN‐γ had no effect on the cell content of SMA. This is the first documentation of the presence of SMA‐positive cells in the human rotator cuff tendon. SMA has been found in a number of other healing connective tissues including skin, ligament, meniscus, cartilage, and other types of tendon. Of importance are previous findings that SMA‐positive cells can contract a collagen‐glycosaminoglycan analog of extracellular matrix in vitro. The results of the present study thus suggest that SMA‐containing cells could contribute to the retraction of the torn ends of a ruptured rotator cuff and play an important role in healing. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Early anchoring collagen fibers at the bone—tendon interface are conducted by woven bone formation: light microscope and scanning electron microscope observation using a canine model
Authors: Oguma Hiroshi , Murakami Gen , Takahashi‐Iwanaga Hiromi , Aoki Mitsuhiro , Ishii Seiichi 
Published: July 2002

AbstractTo clarify the early process of recovery at the bone‐tendon interface, we used light microscopy and SEM to examine the process of anchoring of collagen fibers to bone in a canine model.At two weeks, tendon, scar tissue, woven bone and lamellar bone were present at the insertion site. SEM revealed anchoring of collagen fibril bundles of the scar to the woven bone. By 4 weeks, the number of anchoring fibers had increased and a parallel arrangement of fibers was observed. SEM demonstrated deep penetration of fibers into the woven bone layer. In addition, the fibers were observed to project into and intermingle with the scar tissue. By 6 weeks, the anchoring fibers had developed fully and were distributed densely over the interface. SEM also revealed that the collagen fibril bundles in the scar tissue had connected with the collagen fibrils of the woven bone by way of the anchoring bundles. The woven bone was identifiable throughout the early stages of recovery as the interface between soft tissue and hard tissue. Throughout all experimental periods, no staining was observed at the interface of the tendon and bone by Saffranin‐O. The formation of woven bone was important during early recovery of the tendonbone interface prior to the completion of fibrocartilage‐mediated insertion. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Occurrence and clinical correlates of psychiatric co-morbidity in delusional disorder
Authors: Maina G. , Albert U. , Badà A. , Bogetto F. 
Published: July 2002

SummaryThe present study investigated the occurrence and the clinical correlates of psychiatric co-morbidity in a sample of 64 patients with delusional disorder (DD). Subjects were evaluated with a semi-structured interview for the collection of demographic and clinical features of the disorder; co-morbid axis 1 disorders were determined according to the clinical interview using DSM-IV by Othmer and Othmer. Delusional disorder subjects with and without co-morbid diagnoses were compared to investigate whether the presence of another psychiatric disorder influenced the clinical features of the illness.Seventy-two percent of the subjects had at least one additional lifetime psychiatric diagnosis. High lifetime co-morbidity was found with affective disorders, whose onset generally had been subsequent to the onset of DD. Patients with at least one co-morbid disorder (N = 46) had an earlier age at onset, presented for the first psychiatric consultation at an earlier age, and were younger at index evaluation for this study with respect to patients without co-morbidity (N = 18). Types of DD differed significantly according to the presence/absence of lifetime co-morbid disorders: DD patients with co-morbidity were in most cases persecutory type (54.4%) while DD patients without co-morbidity were mixed type (66.7%).Our data indicate that there is a considerable proportion of patients whose DDr is strictly connected with other co-occurring psychiatric disorders (mainly affective disorders), which exert an influence on the phenomenology of the illness.
Partial left ventriculectomy: sunrise or sunset?
Authors: Starling Randall C. , McCarthy Patrick M. 
Published: July 2002

AbstractPartial left ventriculectomy (PLV) was proposed as an alternative to cardiac transplantation for patients with advanced heart failure. Patients with dilated cardiomyopathy that were considered eligible candidates for cardiac transplantation were offered the option of surgical ventriculectomy or to continue waiting for a donor organ. Sixty‐two patients underwent PLV between May 1996 and December 1998, mean age 54 years, 47 males, mean ejection fraction 13.5%, mean peak oxygen consumption 10.8 ml/kg/min, 39% NYHA class III and 61% NYHA IV. Perioperative mortality 3.2%, 10/62 (16%) required implant of a left ventricular assist device (LVAD) due to shock, most in the early post‐operative period. Survival at 1 and 2 years was 78% and 68%. Event free survival (freedom from death, LVAD, or return of NYHA class IV failure) was 50% and 37% at 1 and 2 years. Event free survivors experienced improvement in NYHA class (3.7 to 2.2) and increased oxygen consumption (11.7 to 16.0 ml/kg/min). Based on these data PLV has a significant early failure rate and a 2 year event free survival rate of only 37%. PLV does not yield outcomes equivalent to cardiac transplantation based on current selection criteria and requires further investigation to determine its role in the treatment of advanced heart failure.