bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide association study of cyanogenic glycosides, proline, sugars, and pigments in Eucalyptus cladocalyx after 18 consecutive dry summers
Authors: Mora‐Poblete Freddy , Ballesta Paulina , Lobos Gustavo A. , Molina‐Montenegro Marco , Gleadow Roslyn , Ahmar Sunny , Jiménez‐Aspee Felipe 
Published: January 2021

AbstractNatural variation of cyanogenic glycosides, soluble sugars, proline, and nondestructive optical sensing of pigments (chlorophyll, flavonols, and anthocyanins) was examined in ex situ natural populations of Eucalyptus cladocalyx F. Muell. grown under dry environmental conditions in the southern Atacama Desert, Chile. After 18 consecutive dry seasons, considerable plant‐to‐plant phenotypic variation for all the traits was observed in the field. For example, leaf hydrogen cyanide (HCN) concentrations varied from 0 (two acyanogenic individuals) to 1.54 mg cyanide g−1 DW. Subsequent genome‐wide association study revealed associations with several genes with a known function in plants. HCN content was associated robustly with genes encoding Cytochrome P450 proteins, and with genes involved in the detoxification mechanism of HCN in cells (β‐cyanoalanine synthase and cyanoalanine nitrilase). Another important finding was that sugars, proline, and pigment content were linked to genes involved in transport, biosynthesis, and/or catabolism. Estimates of genomic heritability (based on haplotypes) ranged between 0.46 and 0.84 (HCN and proline content, respectively). Proline and soluble sugars had the highest predictive ability of genomic prediction models (PA = 0.65 and PA = 0.71, respectively). PA values for HCN content and flavonols were relatively moderate, with estimates ranging from 0.44 to 0.50. These findings provide new understanding on the genetic architecture of cyanogenic capacity, and other key complex traits in cyanogenic E. cladocalyx.
Is British output growth related to its uncertainty? Evidence using eight centuries of data
Authors: Bredin Don , Fountas Stilianos , Savva Christos 
Published: January 2021

AbstractWe examine the empirical relationship between output variability and output growth for Britain using data for eight centuries covering the 1270 to 2014 period. Drawing on the economic history literature, we split the full sample period into four subperiods and use GARCH models to measure output growth uncertainty and estimate its effect on average growth. Within each sub‐sample, we allow output growth to depend on the state of the system, for example 2‐regime switching model would switch between high‐growth and low‐growth regimes. We find that the effect of uncertainty on growth differs depending on the existing growth regime. Low‐growth regimes are associated with a negative effect of uncertainty on growth, and medium or high‐growth regimes are associated with a positive effect. These findings are consistent across the four states of economic development. Our results indicate why the empirical literature to date has found mixed results when examining the effect of uncertainty on growth.
Retrospective evaluation of the performance of the electrical impedance spectroscopy system Nevisense in detecting keratinocyte cancers
Authors: Liebich Christoph , von Bruehl Marie‐Luise , Schubert Irene , Oberhoffer Renate , Sander Christian 
Published: January 2021

AbstractBackgroundKeratinocyte cancers, also referred to as non‐melanoma skin cancers (NMSCs), are one of the most common malignant skin tumors. We performed a retrospective analysis of lesions from patients of a private dermatology practice to evaluate the use of electrical impedance spectroscopy (EIS) in detecting keratinocyte malignancies. The aim of the study is to assess the accuracy of the technique and to rate its use as supportive tool in NMSC diagnosis.Material and MethodsThe period evaluated ranges from September 2015 to November 2019. In total, 1712 lesions from 951 patients were included. All lesions suspicious for malignancy were gauged with the Nevisense device. Excised lesions were sent in for histopathological classification, and the results were compared to the Nevisense score.ResultsA total of 767 lesions (44.8%) received a negative score (0‐3) from the Nevisense system and 945 lesions (55.2%) a positive score (4‐10). The combination of the dermatologist's visual assessment plus the technical determined Neviscore resulted in the excision of 52.5% of all 1712 suspicious lesions whereof 15% were found to be malignant. The sensitivity of Nevisense was 98.4% for NMSC detection.ConclusionElectrical impedance spectroscopy was found to be a valuable adjunct support tool in clinical decisions for cases with suspicion for NMSC.
Sending money home: Transaction cost and remittances to developing countries
Authors: Ahmed Junaid , Mughal Mazhar , Martínez‐Zarzoso Inmaculada 
Published: January 2021

AbstractReducing the cost of remitting is one of the targets within the 2030 Sustainable Development Goals (SDG 10). A key factor that causes migrants to use informal channels when sending money back home is the high cost of transferring funds through formal channels. This study examines whether and to what extent the reduction in the cost of sending remittances increases the flow of remittances to developing countries, and whether larger amounts are remitted when the cost per transaction decreases (the so‐called scale effect). It uses bilateral data on remittance flows and exploits a novel dataset covering transaction costs for 30 sending and 75 receiving countries for the period 2011–2017. A gravity model of remittance flows is estimated using panel data and instrumental variable techniques to address endogeneity issues. We find that transaction cost is a significant predictor of the volume of formal remittances. A 1% decrease in the cost of remitting USD 200 leads to about a 1.6% increase in remittances. This association is robust to the different models and techniques employed. The findings suggest that policies designed to increase formal remittances need to focus on decreasing the cost of remitting through formal channels.
Numerical Investigation of the Dynamical Behavior of a Fluid-Filled Microparticle Suspended in Human Arteriole
Authors: El Jirari I. , El Baroudi A. , Ammar A. 
Published: January 2021

Abstract
The study of artificial microparticles (capsules and vesicles) has gained a growing interest with the emergence of bio-engineering. One of their promoting applications is their use as therapeutic vectors for drug delivery, when capsules and vesicles release their capacity in a targeted environment. The dynamic behavior of capsules and vesicles in confined or unbounded flows was widely studied in the literature and their mechanical response was truthfully described using constitutive laws with good agreement with experiences. However, in a context of biological application, to our knowledge, none of published studies investigating the mechanical response of deformable microparticle took into account the real physiological conditions: the rheological properties of blood such as carrying fluid and the mechanical properties of blood vessels. In this paper, we consider a hyperelastic microparticle suspended in human arteriole. We investigate the deformation of the microparticle resulting from its interaction with blood flow and the arteriolar wall using various capillary numbers and respecting physiological properties of blood and arterial wall. The influence of the blood viscosity model (Newtonian versus shear thinning) is investigated and a comparison with a rigid microchannel and a muscle-embedded arteriole is carried out. The fluid structure interaction (FSI) problem is solved using arbitrary Lagrangian Eulerian (ALE) method. Our simulations have revealed that the arteriolar wall distensibility deeply influences both the deformation and velocity of the microparticle: the deformation strongly increases while the velocity decreases in comparison to an infinitely rigid wall. In the context of therapeutic procedure of targeted drug-delivery, a particular attention should be addressed to these observations, in particular for their implication in the burst mechanism.
Spectral Imaging and Computer Vision for High-Throughput Defect Detection and Root-Cause Analysis of Silicon Nanopillar Arrays
Authors: Gawlik Brian , Barr Ariel R. , Mallavarapu Akhila , Yu Edward T. , Sreenivasan S. V. 
Published: January 2021

Abstract
Far-field spectral imaging, coupled with computer vision methods, is demonstrated as an effective inspection method for detection, classification, and root-cause analysis of manufacturing defects in large area Si nanopillar arrays. Si nanopillar arrays exhibit a variety of nanophotonic effects, causing them to produce colors and spectral signatures which are highly sensitive to defects, on both the macro- and nanoscales, which can be detected in far-field imaging. Compared with traditional nanometrology approaches like scanning electron microscopy (SEM), atomic force microscopy (AFM), and optical scatterometry, spectral imaging offers much higher throughput due to its large field of view (FOV), micrometer-scale imaging resolution, sensitivity to nm-scale feature geometric variations, and ability to be performed in-line and nondestructively. Thus, spectral imaging is an excellent choice for high-speed defect detection/classification in Si nanopillar arrays and potentially other types of large-area nanostructure arrays (LNAs) fabricated on Si wafers, glass sheets, and roll-to-roll webs. The origins of different types of nano-imprint patterning defects—including particle voids, etch delay, and nonfilling—and the unique ways in which they manifest as optical changes in the completed nanostructure arrays are discussed. With this understanding in mind, computer vision methods are applied to spectral image data to detect and classify various defects in a sample containing wine glass-shaped Si resonator arrays.
Thermal-Hydraulic Characterization of Shell-Side Flow in a Cryogenic Coiled Finned-Tube Heat Exchanger
Authors: Howard Jonathon , Hasan Nusair , Knudsen Peter 
Published: January 2021

Abstract
Coiled finned-tube heat exchangers, also called Collins type heat exchangers, are frequently used in small- to medium-scale cryogenic systems to improve design packaging (compactness) while maintaining high thermal effectiveness. A typical heat exchanger assembly of this kind consists of an inner cylindrical shell, called the mandrel, with helical finned-tube coils wrapped around it, and then enclosed by an outer shell. One flow path is through the helically wrapped tube, and the other flow path through annular flow region of the tubes. These are also known as tube and shell streams, respectively. An accurate description of the shell-side thermal-hydraulic flow characteristics is a necessary part of the heat exchanger design. In this paper, these characteristics for cryogenic gaseous nitrogen, between 300 and 100 K, are numerically investigated. A computational fluid dynamics model of the shell-side geometry is developed and validated. Simulations are carried out for a wide range of flow conditions. Data obtained from the numerical simulations are used to form correlations between the shell-side Reynolds number (Re), Fanning friction factor (f), and Chilton-Colburn factor (j). In addition, the effect of geometrical variance on the correlation was investigated. The results from this study show reasonable agreement with experimental data.
Design and Fabrication of Custom-Fit BiPAP and CPAP Masks Using Three-Dimensional Imaging and Three-Dimensional Printing Techniques
Authors: Martelly Erica , Rana Sandeep , Shimada Kenji 
Published: January 2021

Abstract
Noninvasive ventilator support such as bi-level positive airway pressure (BiPAP) or continuous positive airway pressure (CPAP) is often used for patients with obstructive sleep apnea or neuromuscular disorders, such as amyotrophic lateral sclerosis (ALS), where respiratory muscles are weakened. Current commercially available masks for BiPAP and CPAP are often cited as being ill-fitting and leaky, leading to poor quality of sleep or reduced usage of therapy. This project seeks to minimize leaks and maximize comfort by developing custom-fit masks. Patient faces are imaged using an in-house camera system to obtain a three-dimensional (3D) facial contour. Custom interfaces are generated based on this contour using interactive computer software. Using 3D printing to enable rapid tooling, these interfaces are produced in a skin-safe silicone and attached to an off-the-shelf (OTS) mask to create a custom mask. The methodology has been initially tested on five healthy subjects who underwent a two-night sleep study, one night with an OTS mask and one night with a custom-fit mask, to evaluate the leakage and comfort of the custom-fit mask compared to the OTS version. Subjects filled out a questionnaire asking them about mask comfort, leakage, and quality of sleep along with open-ended questions. While the custom-fit mask did not reduce the average measured leakage for subjects, subjects reported experiencing less leakage. Overall, results suggest that the custom-fit masks are more comfortable and tolerable than the provided OTS option. Subject feedback will be implemented into future masks that will be used in a clinical study.
Experimental and Numerical Investigation of Flow and Heat Transfer in Stationary Two-Pass Rectangular Duct (AR = 1:2) With Continuous and Broken V-Shaped Ribs
Authors: Erelli Ramesh , Saha Arun K. 
Published: January 2021

Abstract
The combined experimental and large eddy simulations (LES) were performed in the stationary two-pass duct of aspect ratio (AR) 1:2. The experiments were conducted with three different rib arrangements, namely, 60 deg V, 60 deg V–IV, and broken 60 deg V–IV ribs, and the analysis was carried out with Reynolds numbers of 45,000, 60,000, and 75,000. The infrared thermography (IRT) technique is employed to obtain the local temperature distribution on heated smooth and ribbed surfaces. In all ribbed cases, the copper ribs are glued to the heated surface with a fixed rib height-to-hydraulic diameter (e/Dh) ratio of 0.125 and the rib pitch-to-height ratio (P/e) of 10 and 5 for continuous and broken ribs, respectively. In addition, the LES turbulence model was adopted for carrying out a simulation to understand the flow and heat transfer behavior in ducts populated with all three V-shaped ribs. The comparison of the time-averaged thermal fields generated using computations has been made with experimentally measured Nusselt numbers, friction factors, thermal performance factor (TPF), and Reynolds analogy performance parameter (RAPP) for all cases. The overall thermal performance factor was found to be quantitatively within 8.0–10.66% between experimental and numerical results. Among all the cases, the 60 deg V–IV ribbed duct provides the best TPF and RAPP than the other two ribbed ducts, whereas the smooth duct shows poor TPF.
Isothermal Versus Sensible Cold Storage: A Model-Based Performance Comparison for Pumped Thermal Electricity Storage
Authors: Miklavcic Peter M. , Gluesenkamp Kyle R. , Ishmael Mitchell 
Published: January 2021

Abstract
Pumped-thermal energy storage (PTES) systems consume and produce electrical energy using thermal storage media as an intermediate stage. PTES lends itself to long-duration energy storage to facilitate high penetration of intermittent electricity generation. This study presents a model-based comparison of two thermal storage types within a PTES system: a conventional, single-phase, stratified water-glycol sensible storage system (SGS), and an ideal isothermal, two-phase heat exchanger that freezes a water reservoir (isothermal heat exchanger (IHEX)). The SGS thermal storage capacity is based on the liquid’s sensible heat change with temperature, whereas the capacity of the IHEX is based on the latent heat of isothermally freezing and melting water. The idealized IHEX modeled here undergoes steady-state melting and freezing (in contrast to transient rates, as observed with ice-on-coil storage). A computational model of a complete PTES system is presented and used to evaluate the PTES system-level performance with each type of cold storage. Compared to SGS-based PTES, under nominal operating conditions, the IHEX-based PTES increased electrical round-trip efficiency from 61% to 82% and increased energy density from 1.13 to 8.09 kWh/m3 The performance of the PTES configured with IHEX storage was also analyzed under varying operating parameters.
Experimental Evaluation of Volatile Organic Compound Quantification Methods for Reciprocating Natural Gas Engines
Authors: King Brenna , Venkitachalam Mukund , Olsen Daniel 
Published: January 2021

Abstract
Compressor stations utilizing large-bore natural gas engines transport natural gas through pipelines worldwide. One emission class regulated by the Environmental Protection Agency (EPA) is volatile organic compounds (VOCs), which are nonmethane, nonethane, nonaldehyde hydrocarbons. The combination of a gas chromatograph (GC) and a flame ionization detector (FID) can measure VOCs, following EPA Method 18/25A. The Fourier transform infrared spectrometer (FTIR) also measures VOCs, following EPA Method 320. Multiple VOC calculation techniques are utilized, some combining measurements from separate analyzers. Two basic methods of extracting exhaust gas are direct extraction and Tedlar bag sampling. In this study, various VOC quantification methods are evaluated. Exhaust gas was sampled from a Cooper-Bessemer GMV lean-burn engine and a Caterpillar G3304 rich-burn engine. The GMV was tested in three configurations: open chamber spark ignition, precombustion chamber (PCC) ignition, and PCC ignition with high-pressure fuel injection. Ignition timing sweeps were performed on both engines, and a fuel variability test was performed on the GMV. Results showed that the Gasmet and MKS FTIRs’ (Method 320) VOC measurements deviate significantly from the HP GC when measuring low molar concentrations, albeit below regulatory limits. A common VOC quantification approach is subtracting the sum of methane and ethane FTIR measurements from a total hydrocarbon measurement utilizing a FID. This method produces uncertainties of 190% and overestimates VOC concentration by an average of 100%. The Tedlar bag sampling method produced VOC measurements within −2% of the direct extraction method.
Reviewing recordings of neonatal resuscitation with parents
Authors: den Boer Maria C , Houtlosser Mirjam , Witlox Ruben S G M , van der Stap Roosmarijn , de Vries Martine C , Lopriore Enrico , te Pas Arjan B 
Published: January 2021

BackgroundRecording of neonatal resuscitation, including video and respiratory parameters, was implemented for research and quality purposes at the neonatal intensive care unit (NICU) of the Leiden University Medical Center, and parents were offered to review the recording of their infant together with a neonatal care provider. We aimed to provide insight in parental experiences with reviewing the recording of the neonatal resuscitation of their premature infant.MethodsThis study combined participant observations during parental review of recordings with retrospective qualitative interviews with parents.ResultsParental review of recordings of neonatal resuscitation was observed on 20 occasions, reviewing recordings of 31 children (12 singletons, 8 twins and 1 triplet), of whom 4 died during admission. Median (range) gestational age at birth was 27+5 (24+5–30+3) weeks. Subsequently, 25 parents (13 mothers and 12 fathers) were interviewed.Parents reported many positive experiences, with special emphasis on the value for getting hold of the start of their infant’s life and coping with the trauma of neonatal resuscitation. Reviewing recordings of neonatal resuscitation frequently resulted in appreciation for the child, the father and the medical team. Timing and set-up of the review contributed to positive experiences. Parents considered screenshots/copies of the recording of the resuscitation of their infant as valuable keepsakes of their NICU story and reported that having the screenshots/video comforted them, especially when their child died during admission.ConclusionParents consider reviewing recordings of neonatal resuscitation as valuable. These positive parental experiences could allay concerns about sharing recordings of neonatal resuscitation with parents.
Higher prevalence of fundus haemorrhages in early-screened (NEST Study) as compared to late-screened (SUNDROP Study) newborn populations
Authors: Ludwig Cassie A. , Jabbehdari Sayena , Ji Marco , Vail Daniel , Al-Moujahed Ahmad , Rosenblatt Tatiana , Azad Amee D. , Veerappan Malini , Callaway Natalia F. , Moshfeghi Darius M. 
Published: January 2021

Background/aimsTo determine whether timing of ophthalmic screening influences prevalence of neonatal fundus haemorrhages. We compared the prevalence of fundus haemorrhages in two populations: term newborns screened early (less than 72 hours) and preterm newborns screened late (4–11 weeks). Additionally, we reviewed the literature on timing and prevalence of newborn haemorrhages.MethodsRetrospective observational cohort study. Infants who underwent wide-angle ophthalmic digital imaging over one overlapping year in the Newborn Eye Screen Testing (NEST) or Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) programme were included. The PubMed database was filtered to include English-language articles dating back to 1950. Nine articles were selected for review based on inclusion of the prevalence of newborn fundus haemorrhages at multiple time points.ResultsA total of 202 patients received early imaging in the NEST cohort and 73 patients received late imaging in the SUNDROP cohort. In the NEST cohort, 20.2% of newborns had haemorrhages. In contrast, we found haemorrhages in only one case or 1.4% of the SUNDROP cohort. Using prevalence data from nine additional studies, we developed a predicted probabilities model of newborn haemorrhages. Per this model, the probability of seeing a haemorrhage if you screen an infant at 1 hour is 18.8%, at 2 weeks is 2.9% and at 1 month is 0.28%.ConclusionWe found a significant difference in the prevalence of fundus haemorrhages between the early-screened NEST cohort and the late-screened, preterm SUNDROP cohort. Likely, this difference is due to the transient nature of most newborn haemorrhages.