bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of a stochastic COVID-19 epidemic model with jump-diffusion
Authors: Tesfay Almaz , Saeed Tareq , Zeb Anwar , Tesfay Daniel , Khalaf Anas , Brannan James 
Published: May 2021

AbstractFor a stochastic COVID-19 model with jump-diffusion, we prove the existence and uniqueness of the global positive solution. We also investigate some conditions for the extinction and persistence of the disease. We calculate the threshold of the stochastic epidemic system which determines the extinction or permanence of the disease at different intensities of the stochastic noises. This threshold is denoted byξwhich depends on white and jump noises. The effects of these noises on the dynamics of the model are studied. The numerical experiments show that the random perturbation introduced in the stochastic model suppresses disease outbreak as compared to its deterministic counterpart. In other words, the impact of the noises on the extinction and persistence is high. When the noise is large or small, our numerical findings show that COVID-19 vanishes from the population if$\xi <1$ξ<1; whereas the epidemic cannot go out of control if$\xi >1$ξ>1. From this, we observe that white noise and jump noise have a significant effect on the spread of COVID-19 infection, i.e., we can conclude that the stochastic model is more realistic than the deterministic one. Finally, to illustrate this phenomenon, we put some numerical simulations.
The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis
Authors: Hajikhani Bahareh , Goudarzi Mehdi , Kakavandi Sareh , Amini Sana , Zamani Samira , van Belkum Alex , Goudarzi Hossein , Dadashi Masoud 
Published: May 2021

Abstract
Background and aim
Staphylococcus aureus (S. aureus) is one of the most common pathogens causing nosocomial and community-acquired infections with high morbidity and mortality rates. Fusidic acid has been increasingly used for the treatment of infections due to methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The present study aimed to determine the precise prevalence of fusidic acid resistant MRSA (FRMRSA), fusidic acid resistant MSSA (FRMSSA), and total fusidic acid resistant S. aureus (FRSA) on a global scale.

Methods
Several international databases including Medline, Embase, and the Web of Sciences were searched (2000–2020) to discern studies addressing the prevalence of FRSA, FRMRSA, and FRMSSA. STATA (version14) software was used to interpret the data.

Results
Of the 1446 records identified from the databases, 215 studies fulfilled the eligibility criteria for the detection of FRSA (208 studies), FRMRSA (143 studies), and FRMSSA (71 studies). The analyses manifested that the global prevalence of FRSA, FRMRSA, and FRMSSA was 0.5%, 2.6% and 6.7%, respectively.

Conclusion
This meta-analysis describes an increasing incidence of FRSA, FRMSSA, and FRMRSA. These results indicate the need for prudent prescription of fusidic acid to stop or diminish the incidence of fusidic acid resistance as well as the development of strategies for monitoring the efficacy of fusidic acid use.
Environmental implications of soil erosion and sediment yield in Lake Hawassa watershed, south-central Ethiopia
Authors: Degife Arega , Worku Hailu , Gizaw Shumete 
Published: May 2021

Abstract
Background
Assessing soil erosion, sediment yield and sediment retention capacity of watersheds is one of the under-researched areas in watersheds of developing countries like Lake Hawassa watershed. The study examined soil erosion and sediment yield and their environmental implications in the Lake Hawassa watershed. The quantification and mapping were carried out using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model. Data such as Land Use Land Cover (LULC), Digital Elevation Model (DEM), rainfall, soil, and management practice were used as input parameters.

Results
The empirical analysis confirmed that the watershed has a total soil loss of about 5.27 Mt annually. The mean annual erosion rate from the watershed was estimated to be 37 t ha−1 year−1. The estimated erosion rate was greater than the maximum tolerable erosion limit in Ethiopia (2–18 t ha−1 year−1). The total amount of sediment which was exported to the nearby streams and lakes in the watershed was estimated to be 1.6 t ha−1 year−1. The water bodies receive a total of 226,690.3 t of sediment annually. Although higher soil loss and sediment export per unit of area were estimated from the highest slope gradients, greater contributions to the total soil loss and sediment export were computed from slopes with 5–30% gradients. In terms of LULC, the highest contribution to the total soil loss was computed from cultivated land while the highest rate of soil loss per hectare was observed from bare land. Due to the existing vegetative cover, a total of 18.65 Mt (130.7 t ha−1 year−1) of sediment was retained. Vegetation-covered LULCs such as forest, woodland, shrubland, and agroforestry revealed the highest sediment retention capacity. As a result of the increased soil erosion and sediment yield in the watershed, the drying-out of a small lake and the rise in the water level of Lake Hawassa were identified.

Conclusion
Most of the soil loss and sediment yield were contributed by a small part of the watershed. Thus, the results underscore the urgent need for targeted soil and water conservation measures of various types to ensure the sustainability of the watershed resources.
Improved response of human gingival fibroblasts to titanium coated with micro-/nano-structured tantalum
Authors: Zhang Chu-nan , Zhou Lin-yi , Qian Shu-jiao , Gu Ying-xin , Shi Jun-yu , Lai Hong-chang 
Published: May 2021

Abstract
Objectives
This study aims to evaluate the ability of tantalum-coated titanium to improve human gingival fibroblasts’ adhesion, viability, proliferation, migration performance, and the potential molecular mechanisms.

Materials and methods
Titanium plates were divided into two groups: (1) no coating (Ti, control), (2) Tantalum-coated titanium (Ta-coated Ti). All samples were characterized by scanning electronic microscopy, surface roughness, and hydrophilicity. Fibroblasts’ performance were analyzed by attached cell number at 1 h, 4 h, and 24 h, morphology at 1 h and 4 h, viability at 1 day, 3 days, 5 days, and 7 days, recovery after wounding at 6 h, 12 h, and 24 h. RT-PCR, western blot were applied to detect attachment-related genes’ expression and protein synthesis at 4 h and 24 h. Student’s t test was used for statistical analysis.

Results
Tantalum-coated titanium demonstrates a layer of homogeneously distributed nano-grains with mean diameter of 25.98 (± 14.75) nm. It was found that after tantalum deposition, human gingival fibroblasts (HGFs) adhesion, viability, proliferation, and migration were promoted in comparison to the control group. An upregulated level of Integrin β1 and FAK signaling was also detected, which might be the underlying mechanism.

Conclusion
In the present study, adhesion, viability, proliferation, migration of human gingival fibroblasts are promoted on tantalum-coated titanium, upregulated integrin β1 and FAK might contribute to its superior performance, indicating tantalum coating can be applied in transmucosal part of dental implant.

Clinical significance
Tantalum deposition on titanium surfaces can promote human gingival fibroblast adhesion, accordingly forming a well-organized soft tissue sealing and may contribute to a successful osseointegration.
Polypharmacy-associated potential contraindications of drug prescriptions in patients with primary angle closure disease in a real-world setting
Authors: Tanaka Fumiaki , Shibatani Naoki , Fujita Kazumi , Ikesue Hiroaki , Yoshimizu Satoru , Muroi Nobuyuki , Kurimoto Yasuo , Hashida Tohru 
Published: May 2021

Abstract
Background
Primary angle closure disease (PACD) is a type of glaucoma in which the intraocular pressure (IOP) is increased because of the blockage of the anterior chamber angle. Medications contraindicated for patients with PACD, such as anticholinergics, cause mydriasis, and can elevate IOP. However, anticholinergics are currently contraindicated only for primary angle closure glaucoma (PACG) in Japanese package inserts. In this study, we investigated the prescription status of medications contraindicated for PACD, such as anticholinergics, in patients with PACD scheduled for eye surgeries.

Methods
Forty-three Japanese patients diagnosed with PACD at Kobe City Eye Hospital, Japan, and scheduled hospitalization for eye surgeries between December 2017 and July 2018, were included. Data, including sex, age, diagnosis, IOP, anterior chamber depth, and patients’ regular medications prior to hospitalization, were collected for each patient from the electronic medical records.

Results
The number of patients with chronic primary angle closure (CPAC) and acute primary angle closure (APAC) was 35 (81.4%) and 8 (18.6%), respectively. Among all the 43 patients with PACD, 8 (18.6%) received 15 medications that are potentially contraindicated for PACD by non-ophthalmologist. According to medication categories, benzodiazepine hypnotics were the most commonly prescribed. Among the 8 patients with APAC, 2 (25.0%) had routinely received medications contraindicated for PACD. The median number of all kinds of prescriptions on the day of hospitalization was significantly higher for patients who received medications contraindicated for PACD than for those who did not receive them (p = 0.010).

Conclusions
About 20% of patients with PACD received medications potentially contraindicated for PACD, such as anticholinergics. Attention should be paid to patients prescribed multiple drugs for adverse events, such as increase in intraocular pressure.
Feasibility assessment of an 8-week attention-based training programme in the management of chronic spontaneous urticaria
Authors: Ridge Katie , Conlon Niall , Hennessy Martina , Dunne Pádraic J. 
Published: May 2021

Abstract
Background
Chronic spontaneous urticaria is a common disorder that is poorly understood and frequently misdiagnosed. Psychological difficulties are a significant factor in dermatological diseases and may also aggravate symptom burden. Mind-body interventions are used as a complementary approach to alleviate symptoms in chronic diseases and may represent a valuable non-pharmacological approach in CSU.

Methods
We sought to develop and evaluate the feasibility of an 8-week attention-based training (ABT) programme, coupled to biofeedback technology for CSU. Through convergent interviews, we gathered information from individuals with urticaria about possible links between stress, mood and skin symptoms. Using these data, we recruited 12 participants to engage in an amended ABT programme for patients with CSU, comprising eight 90-min sessions held weekly. Participants completed psychometric measures and measures of urticaria symptomatology as assessed by the urticaria control test, prior to and after the intervention. Adherence to ABT practice was measured using individual inner balance devices which tracked heart rate variability. We completed qualitative interviews after the intervention to obtain feedback on participant experience of the programme.

Results
Participants with CSU described how their psychological wellbeing can be linked to skin symptoms, poor sleep and difficulty concentrating. An amended ABT programme was found to be an acceptable component of care in the management of CSU. Retention of participants in the programme was challenging with 33% participants dropping out of the programme. For those who did complete the programme, three participants exceeded weekly practice at week 8. A decrease in severity of urticaria symptomatology as measured by the urticaria control test was observed upon completion of the intervention. The most commonly cited barrier to implementation of the programme was the time commitment required.

Conclusions
Integrating an ABT programme into routine clinical care for CSU patients is feasible and was deemed acceptable and valuable by individuals who took part. Further formal evaluation of ABT for CSU including the analysis of biochemical parameters is required to determine its role in the management of this distressing condition.

Trial registration
This trial is registered with ISRCTN with study ID ISRCTN13672947. Registration took place on 22/09/2020 (retrospectively registered).
Predictors of contraceptive discontinuation among postpartum women in Arusha region, Tanzania
Authors: Mahande Michael J. , Sato Ryoko , Amour Caroline , Manongi Rachel , Farah Amina , Msuya Sia E. , Elewonibi Bilikisu , Shah Iqbal 
Published: May 2021

Abstract
Background
Postpartum contraceptive discontinuation refers to cessation of use following initiation after delivery within 1 year postpartum. Discontinuation of use has been associated with an increased unmet need for family planning that leads to high numbers of unwanted pregnancies, unsafe abortion or mistimed births. There is scant information about contraceptive discontinuation and its predictors among postpartum women in Tanzania. This study aimed to determine predictors of contraception discontinuation at 3, 6, 12 months postpartum among women of reproductive age in Arusha city and Meru district, Tanzania.

Methods
This was an analytical cross-sectional study which was conducted in two district of Arusha region (Arusha city and Meru district respectively). A multistage sampling technique was used to select 13 streets of the 3 wards in Arusha City and 2 wards in Meru District. A total of 474 women of reproductive age (WRAs) aged 16–44 years residing in the study areas were included in this analysis. Data analysis was performed using STATA version 15. Odds ratios (ORs) with 95% confidence interval (CI) for the factors associated with contraceptives discontinuation (at 3, 6 and 12 moths) were estimated in a multivariable logistic regression model.

Results
Overall, discontinuation rate for all methods at 3, 6, and 12 months postpartum was 11, 19 and 29% respectively. It was higher at 12 months for Lactational amenorrhea, male condoms and injectables (76, 50.5 and 36%, respectively). Women aged 40–44 years had lower odds of contraceptive discontinuation at 3 months as compare to those aged 16 to 19 years. Implants and pills users had also lower odds of contraceptive discontinuation compared to injectable users at 3, 6 and 12 months respectively.

Conclusion
Lactational amenorrhea, male condoms and injectables users had the highest rates of discontinuation. Women’s age and type of method discontinued were independently associated with postpartum contraceptive discontinuation. Addressing barriers to continue contraceptive use amongst younger women and knowledge on method attributes, including possible side-effects and how to manage complications is warranted.
Subfascial‐located contraceptive devices requiring surgical removal
Authors: Hellwinkel Justin E. , Konigsberg Matthew W. , Oviedo Johana , Castaño Paula M. , Kadiyala R. Kumar 
Published: May 2021

Abstract
Background
Subdermal etonogestrel implants are highly effective contraceptive methods. Despite standardization of insertion technique by the manufacturer, some implants are inadvertently placed too deeply within or below the plane of the biceps brachii fascia. Placement of these implants in a deep tissue plane results in more difficult removal, which is not always possible in the office setting. In rare cases, surgical removal by an upper extremity surgeon is warranted.

Case presentation
Here we present 6 cases of etonogestrel implants located in a subfascial plane requiring removal by an upper extremity surgeon. Implants were all localized with plain radiography and ultrasound prior to surgical removal. All cases had implants located in the subfascial plane and one was identified intramuscularly. The average age was 28 years (19–33) and BMI was 24.0 kg/m^2 (19.1–36.5), with the most common reason for removal being irregular bleeding. The majority of cases (5/6) were performed under monitored anesthesia care with local anesthetic and one case utilized regional anesthesia. All implants were surgically removed without complication.

Conclusions
Insertion of etonogestrel contraceptive implants deep to the biceps brachii fascia is a rare, but dangerous complication. Removal of these implants is not always successful in the office setting and referral to an upper extremity surgeon is necessary to avoid damage to delicate neurovascular structures for safe removal.
Isolation, self-blame and perceived invalidation in aid personnel: identifying humanitarian-specific distress using the PostAID/Q
Authors: McCormack Lynne , Douglas Heather , Joseph Stephen 
Published: May 2021

Abstract
Objective
Humanitarian-specific psychological distress following deployment can elude detection using contemporary measures of trauma-related stress. This study assesses the unidimensional structure and convergent validity of the Post-deployment Altruistic Identity Disruption Questionnaire (PostAID/Q), an 18-item questionnaire underpinned by the construct Altruistic Identity/Disruption (AI/AID).

Method
Humanitarian aid personnel (N=108) completed an online web survey, inclusive of the Moral Injury Questionnaire (MIQ), Posttraumatic Distress Disorder Checklist (PCL-5), Psychological Well-Being Posttraumatic Changes Questionnaire (PWB-PTCQ) and Social Provisions Scale (SPS).

Results
A confirmatory factor analysis suggested a single factor structure providing further support for the conception of AI/AID as a unidimensional construct. Convergent validity was demonstrated through (1) utility for predicting a posttraumatic stress disorder (PTSD) diagnosis assessed by the PCL-5, and (2) moral injury assessed by the MIQ. The PostAID/Q was further moderately and negatively associated with the availability of social support (assessed by the SPS) and lower self-reports of psychological well-being post trauma (assessed by the PWB-PCTQ). Finally, the PostAID/Q demonstrated evidence of incremental validity in predicting humanitarian specific psychological distress over and above the PCL-5. Specifically, the PostAID/Q predicted increased moral injury on the MIQ, and decreased psychological well-being post trauma.

Conclusions
The PostAID/Q can assist in identifying humanitarian specific psychological responses post deployment guiding support for personnel, over and above more traditional measures of posttraumatic stress.
Mechanical thrombectomy in patients with cervical artery dissection and stroke in the anterior or posterior circulation – a multicenter analysis from the German Stroke Registry
Authors:   for the GSR-ET investigators, Schlemm Ludwig , von Rennenberg Regina , Siebert Eberhard , Bohner Georg , Flottmann Fabian , Petzold Gabor C. , Thomalla Götz , Endres Matthias , Nolte Christian H. 
Published: May 2021

AbstractBackgroundCervical artery dissection (CAD) is a rare cause of acute ischemic stroke (AIS) with large vessel occlusion (LVO) and may constitute a challenge for mechanical thrombectomy (MT). We compared procedural characteristics, reperfusion rates, and clinical outcome in AIS patients undergoing MT with and without CAD.MethodsWe performed a pre-specified analysis of patients registered within the German Stroke Registry, a prospectively maintained multicenter registry of consecutive patients with AIS patients treated by MT. Procedural characteristics included time periods and additional application of medication.ResultsOf 2589 patients, 62 (2.4%) were diagnosed with CAD. CAD patients were younger, had lower rates of known vascular risk factors and larger baseline stroke volumes. MT in CAD patients took significantly longer (median [IQR] groin-puncture-to-flow restoration time: 98 [67–136] versus 70 [45–100] minutes;p < 0.001) and more often required use of intra-arterial medication (34.4% versus 15.6%;p < 0.001). Reperfusion success (modified Treatment in Cerebral Infarction score 2b-3: 85.2% versus 83.3%,p = 0.690) and favorable functional outcome after 3 months (modified Rankin Scale score ≤ 2: 70.9% versus 36.4%, adjustedp = 0.086) did not differ significantly between patients with and without CAD. The latter findings held true for both CAD in the anterior and posterior circulation.ConclusionCAD in AIS requiring MT is rare. MT in patients with CAD constitutes a particular procedural challenge, but still achieves favorable radiological and functional outcomes in most patients. Our data provide indirect evidence that MT is of clinical benefit in patients with AIS due to LVO and CAD.
Prognostication after intracerebral hemorrhage: a review
Authors: Witsch Jens , Siegerink Bob , Nolte Christian H. , Sprügel Maximilian , Steiner Thorsten , Endres Matthias , Huttner Hagen B. 
Published: May 2021

Abstract
Background
Approximately half of patients with spontaneous intracerebral hemorrhage (ICH) die within 1 year. Prognostication in this context is of great importance, to guide goals of care discussions, clinical decision-making, and risk stratification. However, available prognostic scores are hardly used in clinical practice. The purpose of this review article is to identify existing outcome prediction scores for spontaneous intracerebral hemorrhage (ICH) discuss their shortcomings, and to suggest how to create and validate more useful scores.

Main text
Through a literature review this article identifies existing ICH outcome prediction models. Using the Essen-ICH-score as an example, we demonstrate a complete score validation including discrimination, calibration and net benefit calculations. Score performance is illustrated in the Erlangen UKER-ICH-cohort (NCT03183167). We identified 19 prediction scores, half of which used mortality as endpoint, the remainder used disability, typically the dichotomized modified Rankin score assessed at variable time points after the index ICH. Complete score validation by our criteria was only available for the max-ICH score. Our validation of the Essen-ICH-score regarding prediction of unfavorable outcome showed good discrimination (area under the curve 0.87), fair calibration (calibration intercept 1.0, slope 0.84), and an overall net benefit of using the score as a decision tool. We discuss methodological pitfalls of prediction scores, e.g. the withdrawal of care (WOC) bias, physiological predictor variables that are often neglected by authors of clinical scores, and incomplete score validation. Future scores need to integrate new predictor variables, patient-reported outcome measures, and reduce the WOC bias. Validation needs to be standardized and thorough. Lastly, we discuss the integration of current ICH scoring systems in clinical practice with the awareness of their shortcomings.

Conclusion
Presently available prognostic scores for ICH do not fulfill essential quality standards. Novel prognostic scores need to be developed to inform the design of research studies and improve clinical care in patients with ICH.