bluuebunny/crossref_metadata_2025_split huggingface dataset:
A-77 Nonverbal Memory Dysfunction and Migraine-Related Disability Predict Subjective Cognitive Symptoms in Adults with Migraine
Authors: Sutton Leah C , Klepper Jaclyn , Rosen Noah , Reeder Annie Kate , Schwartz Alexandra , Seng Elizabeth 
Published: August 2021

Abstract

Objective
This study investigated the relationship between subjective cognitive symptom reporting and objective cognitive functioning in adults with migraine.

Method
88 participants (Mdn age = 46.0 [35.25–56.75]; Mdn years of education = 16.0 [13.0–19.0]; 88.6% female) completed neuropsychological testing and questionnaires assessing migraine disability (Migraine Disability Assessment Scale) and subjective cognition (Sickness Impact Profile-Alertness Behavior Subscale). Participants had primary headache disorder diagnosis of migraine. Bivariate correlations and hierarchical linear regression were performed.

Results
83% of participants had episodic migraine (&lt; 15 headache days/month) and 58% reported low or moderate disability (MIDAS ≤21). Subjective cognitive dysfunction was associated with lower education (ρ = −0.254; p = 0.018), higher disability (t(84) = −3.00, p = 0.004); and lower scores on coding (r = −0.224, p = 0.023) TMT-A (r = −0.238, p = 0.029), RCFT- Immediate Recall (r = −0.028, p = 0.010), RCFT- Delayed Recall (r = −0.38, p &lt; 0.001), RCFT-recognition (r = −0.40, p &lt; 0.001), and animal fluency (r = −0.27, p = 0.013). Migraine-related disability and RCFT- Delayed Recall (ß = −0.368, SE = 0.006).) accounted for 45.9% of variance in subjective cognitive symptom reporting. The addition of RCFT-recognition (ß = −0.050, SE = 0.025) increased explanation of variance by 4.1%.

Conclusion
Nonverbal memory dysfunction and higher disability may predict subjective cognitive complaints. This study contributes to the limited knowledge of objective and subjective cognitive functioning in adults with migraine.
A-78 Interdisciplinary Consultation in a Case of Herpes Simplex Encephalitis with Unique Neuropsychiatric Symptoms
Authors: Kaplan Danielle , O'Hara John B , Posada Carolina , Slyne Kristin E 
Published: August 2021

Abstract

Objective
Herpes simplex encephalitis (HSE) is a rare neurological condition (~2–4 per million) marked by brain inflammation caused by herpes simplex virus (HSV). HSE is associated with both cognitive and neuropsychiatric symptoms, particularly memory and executive dysfunction. We present the case of a 63-year-old, right-handed, St. Lucian female who completed serial neuropsychological evaluations (NPE).

Method
The patient presented with a six-day history (per collateral) of fever, confusion, and nausea. The patient denied cognitive changes. Magnetic Resonance Imaging (MRI) revealed leptomeningeal enhancement in the right sylvian fissure, multiple right temporal sulci, and inferior right frontal lobe (Figure 1). There was no indication of seizures. Cerebrospinal fluid analysis was positive for HSV-1. A two-week course of intravenous acyclovir was initiated on hospital day three.

Results
(Table 1). Initial NPE results (day five) revealed global cognitive impairment with sparing of auditory attention; exam was limited secondary to significant fatigue. Following completion of antivirals, subsequent NPE (day 17) revealed similar findings, despite improved alertness; left neglect (Figure 2) and significant anosagnosia (i.e., lack of disease awareness) and anosodiaphoria (i.e., indifference reaction to neurological deficits) were noted. Two-month outpatient follow-up NPE revealed marginal improvement in aspects of language and learning, but continued memory impairment, dense anosagnosia, and anosodiaphoria.

Conclusion
In this case, the patient presented with salient neuropsychiatric sequelae of HSE that have not been commonly associated with this condition in the extant literature. Her denial of cognitive symptoms may have initially confounded the differential diagnosis, emphasizing the importance of multi-specialty collaboration. Limitations of available normative data also complicated examination.
A-79 Case Series Evaluating Quantitative Electroencephalograph and Neuropsychological Function in Neurological Lyme Disease
Authors: Rudd-Barnard Alexandra , Jarvandi Sarah , Rapoport Roxanne , Smith Sue , Witkowska Natalia 
Published: August 2021

Abstract

Objectives
The purpose of this study was to investigate the characteristics of physician diagnosed Neurological Lyme disease (NLD) using Quantitative EEG and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We hypothesize that findings would include more slow wave (Delta/Theta) activity that is consistent with the severity reported dysfunction.

Methods
Subjects consisted of four adult females with a physician provided diagnosis of NLD. EEG was recorded from 21 sites during an eyes open and eyes-closed resting conditions. Raw EEG data was made quantifiable (qEEG) through Fourier transformation to determine z-score derived cortical and subcortical slow wave activity. The RBANS was used to assess each subject’s functioning.

Results
(See Imaging).
Subject 1.
Theta: 3.7.
Alpha: 2.3.
Theta: 3.2.
Alpha: 2.5.
RBANS - 96.
Subject 2.
Theta: 1.9.
Alpha: 3.1.
Theta: 2.3.
Alpha: 4.4.
RBANS - 76.
Subject 3.
Theta: 3.4.
Alpha: 2.8.
Theta: 3.5.
Alpha: 2.1.
RBANS - 110.
Subject 4.
Theta: 3.6.
Alpha: 3.0.
Theta: 3.3.
Alpha: 2.8.
RBANS - 100.

Conclusions
NLD subjects within this study all demonstrated elevated subcortical frontal and frontotemporal theta and alpha. Elevation in cortical slow wave activity was found for subjects with greater reported symptomatology and may suggest either less severe course of disease or serve as a recovery marker. RBANS assessment variables were not completely sensitive in detection of subject reported challenges. Implications for conceptualization, treatment, and disease monitoring are highlighted. Directions for future research will also be discussed.
A-80 Psychosocial Functioning in Pediatric Anti-MOG Associated Disease
Authors: Kennedy Erin E , Hernandez Ana , Greenberg Benjamin , Plumb Patricia , Wang Cynthia , Harder Lana 
Published: August 2021

Abstract

Objective
Anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD) is a newly recognized demyelinating disorder, most commonly associated with acute disseminated encephalomyelitis (ADEM), optic neuritis and/or transverse myelitis. Given that psychosocial problems have previously been noted in individuals with demyelinating disorders, including ADEM, the primary aims of this study were to examine psychosocial functioning in patients with MOGAD and explore differences between subjects with a history of ADEM and those without.

Method
Thirty-two subjects with MOGAD (M age = 10.57; ADEM = 59.4%) and their caregivers completed questionnaires (Behavior Assessment Scales for Children, Pediatric Quality of Life, Educational History Form) to assess psychosocial functioning including externalizing (EXT) and internalizing behaviors (INT), quality of life (QOL), and academic performance.

Results
Overall, caregiver-ratings of internalizing and externalizing behaviors were not significantly different from the normative mean (EXT: p = 0.307; INT: p = 0.775). Caregiver and self-rated QOL was significantly below the normative mean for school and social functioning (p = &lt; 0.05), as was self-rated emotional functioning (p = 0.026). Further analysis did not reveal significant differences between subjects who had ADEM vs. those who did not across caregiver ratings or academic performance. Self-ratings revealed significantly more social problems for subjects with a history of ADEM (p = 0.018).

Conclusions
MOGAD may be associated with few caregiver-reported behavioral or emotional problems. While pediatric patients with MOGAD are noted to have academic and social problems per caregiver report, self-report further indicates problems with emotional QOL and greater risk of social problems for those with a history of ADEM. Additional research is needed to further understand the psychosocial features associated with MOGAD.
COVID-19 OUTCOMES IN PREGNANCY: A REVIEW OF 275 SCREENED STUDIES
Authors: Vijayan Rupalakshmi , Moon Hanna , Joseph Jasmine , Zaidi Madiha , Kamwal Chhaya , Senatus Andrelle , Nagpal Shavy , Diaz Miguel 
Published: August 2021

ABSTRACTIn December 2019, a novel strain of severe acute respiratory syndrome (SARS-CoV-2), was declared as a cause of respiratory illness, called coronavirus 2019 (COVID-19), characterized by fever and cough. In diagnostic imaging, the afflicted population showed pathognomonic findings of pneumonia. What started out as an epidemic in China, rapidly spread across geographical locations with a significant daily increase in the number of affected cases. According to the World Health Organization (WHO) reports, the range of worldwide mortality is 3 to 4%. Maternal adaptations and immunological changes predispose pregnant women to a prolonged and severe form of pneumonia, which results in higher rates of maternal, fetal, and neonatal morbidity and mortality. There is limited data about the consequences of COVID-19 in pregnancy, thereby limiting the prevention, counseling, and management of these patients. The objective of this literature review is to explore pregnancy and perinatal outcomes of COVID-19, complications, morbidity, and mortality in this sub-population. We conducted a literature review pertaining to COVID-19 and pregnancy in databases such as: PubMed, Google Scholar, and Science Direct. The studies we chose to focus on were systematic reviews, meta-analysis, case series, and case reports. Twenty four articles were reviewed regarding COVID-19 and pregnancy, complications and their outcomes. Due to immunological changes during pregnancy as evidenced by the flaring of auto-immune diseases; pregnant women may be at an increased risk for infection. Women (19.7%) who had underlying comorbidities such as gestational DM, HTN, hypothyroidism, and autoimmune disease, COPD, or HBV infection were considered high risk. The most common maternal outcomes were premature rupture of membranes (PROM) and pre-eclampsia. Asthma was the most common comorbidity associated with maternal mortality. The most common neonatal complications were fetal distress leading to NICU admissions and preterm birth <37 weeks. The most common laboratory changes were elevated CRP and lymphocytopenia. Most patients underwent C-section due to their underlying comorbidities. Pregnant and lactating women did not shed viral particles through their vaginal mucus and milk, as evidenced by negative nucleic-acid tests of these secretions. Neonatal infections as demonstrated by positive RT-PCR were rare, but direct evidence supporting intrauterine transmission was not confirmed. Direct evidence indicating vertical transmission of COVID-19 is not available, but risk for transmission cannot be ruled out. Pregnant women should be closely monitored due to increased risk of adverse outcomes.
The relationship among corporate social responsibility, sustainability and organizational performance in pharmaceutical sector: a literature review
Authors: Saxena Kanika , Balani Sunita , Srivastava Pallavi 
Published: August 2021

PurposeThis study aims to review the extant literature in pharmaceutical sector on corporate social responsibility (CSR), sustainability and organizational performance to explore if a relationship exists among these three elements.Design/methodology/approachA total of 301 research articles were collected from online databases. A new ECG framework representing environment, community and growth was used to classify the collected literature under the three elements: CSR, sustainability and organizational performance.FindingsKey findings under the identified categories are: A) Environment: Strict legislation and green chemistry have revolutionized the pharmaceutical sector by decreasing manufacturing costs, minimizing the environmental footprint and improving compliance with regulations. B) Community: Community goodwill and organization’s image have gained importance under the influence of external and internal stakeholders. C) Growth: A weak relationship exists between CSR and organizational performance but increases engagement in sustainability practices which has led to increased market performance. Effective integration of social and environmental goals with strategic business processes could result in long-term profits.Originality/valueThis study focuses on the extant literature to identify the significance of CSR and sustainability on the organizational performance of the pharmaceutical sector. The propositions developed in this study will help in identifying the interdependency of the aforementioned three elements opening further possibilities of in-depth sector specific studies.
Investigating beta anomaly: comparison of Shariah-compliant and conventional stocks
Authors: Qamar Muhammad Ali Jibran , Hassan Asma , Nazir Mian Sajid , Haque Abdul 
Published: August 2021

Purpose
The purpose of this paper is to examine the impact of dividend announcements on the stock return of Shariah-compliant and conventional stocks.

Design/methodology/approach
An event study methodology is applied to study the beta anomaly. Market-adjusted return model, mean-adjusted return model and market model have been applied to calculate excess returns. Estimation period used in this study is 130 days, and event period consists of 21 days in total, i.e. starting from the day –10 “before the cash dividend announcement” to day +10 “after the cash dividend announcements.

Findings
It has been concluded from the results that dividend plays an informational role in the Pakistan Stock Exchange. As the investors in Pakistan react favorably to the dividend increase announcements and unfavorably to the dividend decrease announcements, they consider dividend increase announcement as good news and dividend decrease announcement as bad news.

Practical implications
The findings of this study have several implications for different participants of the stock market, such as investors, academicians, researchers, fund managers and policymakers. They can use this information to make decisions while making efficient portfolios. Investors may get abnormal returns by focusing on the dividend announcement patterns. This can influence the attitude of investors toward efficient investments in the stock market and ultimately contribute to the betterment of society. This study is also beneficial for academicians and researchers, as it provides a comparative analysis of Shariah-compliant and conventional stocks and the anomalous effect of dividend announcements on stock return.

Originality/value
Limited research in the world’s context and null is available in Pakistani context on the subject matter. The comparative analysis of “Shariah-compliant” and “conventional” stocks provides insight into the asset pricing of Shariah-compliant stocks that have not been explored earlier. This study also uses three different methods (mean model, market model and market-adjusted return models) to compare Shariah-compliant and conventional stocks
Life cycle analysis of Brazilian startups: characteristics, intellectual capital, agents and associated risks
Authors: Couto Marcelo Henrique Gomes , Oliva Fábio Lotti , Del Giudice Manlio , Kotabe Masaaki , Chin Tachia , Kelle Peter 
Published: August 2021

PurposeThe purpose of this paper was to present the stages of the Brazilian startups' organizational life cycle (OLC), identifying and describing the main factors related to the entrepreneurial and organizational perspectives, as well as the factors related to external relationship agents and the associated risks at each OLC stage. In addition, the variables that comprised the three perspectives above were used for a descriptive reading of the evolutionary process from the perspective of intellectual capital during the stages.Design/methodology/approachThe type of research used was quantitative with a descriptive character. For data collection, the authors have used the survey method and two complementary questionnaires were used as research tools. The measurement scale used in these instruments was the 11-point Likert scale. In total, 100 Brazilian startups registered in the STARTUPBASE and residents in São Paulo comprised the sample of this research. For the data processing, it was used the exploratory factor analysis techniques, to identify the analysis factors, and the cluster analysis, to identify the OLC stages.FindingsBased on the results obtained, four stages were identified and described to build the OLC model of this research: Stage I – conception and development; Stage II – organization and traction; Stage III – growth and scale; and Stage IV – consolidation and transition. In addition, the authors described the main lines of evidence found at each stage.Practical implicationsThis research contributes to academic studies of the OLC in startups and the evolution of risks that originate from the relationship between external agents in the business environment and startups. Thus, a management map is built, which helps entrepreneurs and managers construct these businesses since such a management map allows identifying the risks and challenges that a startup needs to overcome to grow and develop.Originality/valueThe originality of this research lies in the adaptation of the OLC approach, which is widely used in studies analyzing the growth and development of mature organizations. The authors used this adaptation to analyze the growth and development of startups in Brazil. In addition, the identification and analysis of external agents that make up the business environment, as well as the analysis of the risks, originated from the relationships between the startup and these agents, brought original and essential results and discussions, both for OLC studies and for risk analysis studies in startups.
The connection between freedom of the press and environmental quality: An investigation on emerging market countries
Authors: Uzar Umut 
Published: August 2021

AbstractAlthough there have been many attempts in the literature to identify the main factors of carbon dioxide (CO2) emissions, the influence of freedom of the press on CO2 emissions has not yet been studied. This gap reveals a substantial question: can freedom of the press reduce CO2 emissions? This article is an initial study to reply to this question. In this study, the effects of freedom of the press and other control variables on CO2 emissions in Emerging‐7 (E‐, Turkey, Russia, Mexico, Indonesia, India, China, Brazil) countries for 1993–2016 are examined by panel autoregressive distributed lag (ARDL) model (method. The main finding is that freedom of the press can perform a substantial role in diminishing CO2 emissions in E‐7 countries. In addition, the evidence confirms that the environmental Kuznets curve (EKC) hypothesis is valid. Primary energy consumption and trade are also determined to be important factors that increase CO2 emissions. Within the framework of these results, policymakers must expand the freedom of the press to lower CO2 emissions.
Forced moves and home maintenance: The amplifying effects of mortgage payment burden on underwater homeowners
Authors: Harding John P. , Li Jing , Rosenthal Stuart S. , Zhang Xirui 
Published: August 2021

AbstractAlthough well‐known that high current loan‐to‐value ratio (CLTV) is necessary for mortgage default, the amplifying effect of high payment‐to‐income ratios (PTI) that can force families to move has received limited attention. Using the 1985–2013 American Housing Survey panel, we show that high CLTV by itself has little effect on mobility, but high PTI prompts families to move and especially so when CLTV is high. Evidence also indicates that high PTI and CLTV discourage home maintenance. Our estimates suggest that loan modifications that lower PTI will likely be more effective at helping underwater families to remain in their homes and avoid mortgage default as compared to policies that lower CLTV.
What we can learn from the dynamics of the 1889 ‘Russian flu’ pandemic for the future trajectory of COVID‐19
Authors: Brüssow Harald 
Published: August 2021

SummaryA study of the contemporary medical literature for patient symptoms from the so‐called ‘Russian flu’ pandemic from 1889 revealed clinical observations that resemble COVID‐19 (Brüssow and Brüssow, 2021, Microb Biotechnol). If one accepts the hypothesis that this pandemic was a prior coronavirus epidemic, the dynamics of the ‘Russian flu’ from 1889 might give us some ideas about the future trajectory of the COVID‐19 pandemic. The present report compiles and reviews the contemporary data published on the temporal and geographical spread of the ‘Russian flu’, its epidemic wave structure and possible later resurgence. The historical record of past pandemics might thus provide us not with predictions, but ‘retrodictions’ on possible future scenarios for the COVID‐19 pandemic.
Pembrolizumab associated Stevens–Johnson syndrome with porokeratosis in a patient in the setting of primary hepatocellular carcinoma
Authors: Zhang Jing , Zhang Peng , Xu Qiu‐Yun , Zhu Yan‐Ting , Chen Wen , Ji Chao 
Published: August 2021

AbstractPembrolizumab is a humanised therapeutic antibody against the PD‐1 receptor. It has been used in various advanced cancer immunotherapies. Here, we report an extremely rare case of a 32‐year‐old man who developed Stevens–Johnson syndrome (SJS) with porokeratosis simultaneously during pembrolizumab treatment for primary hepatocellular carcinoma (T3N1M1).
Intra‐arterial combination therapy for experimental acute ischemic stroke
Authors: Maniskas Michael E. , Roberts Jill M. , Gorman Amanda , Bix Gregory J. , Fraser Justin F. 
Published: August 2021

AbstractAcute ischemic stroke continues to devastate millions of individuals worldwide. Current treatments work to restore blood flow but not rescue affected tissue. Our goal was to develop a combination of neuroprotective agents administered intra‐arterially following recanalization to target ischemic tissue. Using C57Bl/6J male mice, we performed tandem transient ipsilateral middle cerebral/common carotid artery occlusion, followed by immediate intra‐arterial pharmacotherapy administration through a standardized protocol. Two pharmacotherapy agents, verapamil and lubeluzole, were selected based on their potential to modulate different aspects of the ischemic cascade; verapamil, a calcium channel blocker, works in an acute fashion blocking L‐type calcium channels, whereas lubeluzole, an N‐methyl‐D‐aspartate modulator, works in a delayed fashion blocking intracellular glutamate trafficking. We hypothesized that combination therapy would provide complimentary and potentially synergistic benefit treating brain tissue undergoing various stages of injury. Physiological measurements for heart rate and pulse distention (blood pressure) demonstrated no detrimental effects between groups, suggesting that the combination drug administration is safe. Tissue analysis demonstrated a significant difference between combination and control (saline) groups in infarct volume, neuronal health, and astrogliosis. Although a significant difference in functional outcome was not observed, we did note that the combination treatment group had a greater percent change from baseline in forced motor movement as compared with controls. This study demonstrates the safety and feasibility of intra‐arterial combination therapy following successful recanalization and warrants further study.