bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysis of the procession from chronic pancreatitis to pancreatic cancer and metastatic pancreatic cancer
Authors: Tu Jihao , Huang Zhehao , Wang Yin , Wang Meijing , Yin Zukun , Mei Xianglin , Li Meiying , Li Lisha 
Published: February 2021

AbstractExploring the underlying mechanisms of cancer development is useful for cancer treatment. In this paper, we analyzed the transcriptome profiles from the human normal pancreas, pancreatitis, pancreatic cancer and metastatic pancreatic cancer to study the intricate associations among pancreatic cancer progression. We clustered the transcriptome data, and analyzed the differential expressed genes. WGCNA was applied to construct co-expression networks and detect important modules. Importantly we selected the module in a different way. As the pancreatic disease deteriorates, the number of differentially expressed genes increases. The gene networks of T cells and interferon are upregulated in stages. In conclusion, the network-based study provides gradually activated gene networks in the disease progression of pancreatitis, pancreatic cancer, and metastatic pancreatic cancer. It may contribute to the rational design of anti-cancer drugs.
Discourse Analysis of Humor After Traumatic Brain Injury
Authors: Keegan Louise C. , Suger Caitlin , Togher Leanne 
Published: February 2021

Purpose
Individuals with cognitive communication difficulties after traumatic brain injury (TBI) often experience difficulties with social communication. Humor is a sociolinguistic skill that requires social, cognitive, emotional, and behavioral skills and, when used effectively, may serve to enhance one's social relationships. There is a paucity of research related to the use of humor in individuals with TBI. This study categorizes humor use in individuals with cognitive communication difficulties after TBI and examines the linguistic construction of these humorous exchanges.

Method
The humorous exchanges of nine individuals who had cognitive communication difficulties after a moderate-to-severe TBI were examined. Conversations were collected from a community-based communication skills group, categorized using thematic analysis methods, and examined linguistically using the discourse analysis tools of systemic functional linguistics.

Results
All participants demonstrated the ability to use a variety of categories of humor, and discourse analysis methods revealed humor use as a strength for engaging with others. Examples of such engagement include use of humor to elicit attention, assert authority, share information, acknowledge shared difficulties, and demonstrate affiliation toward their communication partners.

Conclusions
Discourse analysis of humor can provide speech-language pathologists with important information about the linguistic strengths of individuals with cognitive communication difficulties. This has important implications for clinical service provision.
Student Perspectives on the Role of Peer Support Following Concussion: Development of the SUCCESS Peer Mentoring Program
Authors: O'Brien Katy H. , Wallace Tracey , Kemp Amy 
Published: February 2021

PurposeCollege students with concussion are often ill-equipped to manage their health and learning needs, and college campuses are slow to react. We present the development of a peer mentoring program for college students with concussion: Success in College after Concussion with Effective Student Supports (SUCCESS), focusing on the process by which student needs and preferences drove development of the program for testing.MethodPrinciples of person-centered design were used to guide program development, engaging stakeholders at each stage of development and resulting in the intervention package presented to student participants here. A series of interviews and focus groups with 11 students with concussion addressed student needs after concussion, student perceptions of the role of peers in recovery, and feedback on program development.ResultsFindings indicate students have limited knowledge about concussion, and concussion impacts extend beyond school, although students are most concerned about their studies. Students reported struggling to communicate with professors and find resources on campus to aid in their reentry to learning. Regarding peer mentoring, students report benefiting from hearing about other's successes and sharing personal narratives of injury and recovery. Students reported high acceptability of a peer mentoring program, both for psychosocial support and access to resources.ConclusionsCollege students with concussion have unmet needs as they return to learn. The SUCCESS peer mentoring program is highly acceptable to students, who report that they would expect such a program to be engaging and to meet their needs. The program's impact on student academic and psychosocial outcomes should be investigated through comparative efficacy trials.
Data‐driven parameter tuning for rational feedforward controller: Achieving optimal estimation via instrumental variable
Authors: Huang Weicai , Yang Kaiming , Zhu Yu , Lu Sen 
Published: February 2021

AbstractFeedforward control has been widely used to improve the tracking performance of precision motion systems. This paper develops a new data‐driven feedforward tuning approach associated with rational basis functions. The aim is to obtain the global optimum with optimal estimation accuracy. First, the instrumental variable is employed to ensure the unbiased estimation of the global optimum. Then, the optimal instrumental variable which leads to the highest estimation accuracy is derived, and a new refined instrumental variable method is exploited to estimate the optimal instrumental variable. Moreover, the estimation accuracy of the optimal parameter is further improved through the proposed parameter updating law. Simulations are conducted to test the parameter estimation accuracy of the proposed approach, and it is demonstrated that the global optimum is unbiasedly estimated with optimal parameter estimation accuracy in terms of variance with the proposed approach. Experiments are performed and the results validate the excellent performance of the proposed approach for varying tasks.
Low‐offset differential output switched‐capacitor interface for micro‐capacitive acceleration sensors
Authors: Tirupathi Rakesh , Kar Sougata Kumar 
Published: February 2021

AbstractThis paper presents two simple but effective switched capacitor based differential output capacitive sensor interfaces, designed and fabricated in United Microelectronics Corporation 180 nm complementary metal oxide semiconductor (CMOS) process technology. The first configuration combines chopper modulation and switched capacitor based correlated double sampling, while the second configuration utilises chopper modulation with a modified demodulation scheme to reduce noise and offset. The proposed designs utilise a fully differential operational amplifier (op‐amp) with single‐feedback loop, which reduces the mismatch between the single‐ended outputs in the differential configuration. The proposed configurations are analysed in perspective of noise to achieve high accuracy with less noise and integrated with supporting circuitry. The fabricated application specific integrated circuit (ASIC) is first characterised with the internal on‐chip capacitors and then integrated with micro‐electro‐mechanical systems (MEMS) based differential capacitive accelerometer sensor on a printed circuit board (PCB) for dynamic testing. The integrated PCB and a commercially available accelerometer (ADXL335) is mounted on a sub‐woofer system and the dynamic testing is carried out. The measurement results show that the sensor interface is capable of measuring sub‐fF capacitance change with zero offset less than 2 mV. The first configuration provides sensitivity of 720 mV/g, whereas the second configuration attains sensitivity of 385 mV/g. The noise floors are 400 , 325 , whereas the capacitance resolutions are 70 and 60 aF, respectively.
Current status and development trends of efficient oil production testing technology
Authors: Kun Ning , Gang Yu , Lingyu Mu , Xi Wu 
Published: February 2021

Oil production testing is a critical tool to understand reservoir properties and well producibility. The development of oil production testing technology in China has mainly gone through three phases: conventional oil production testing phase, oil production testing phase, and integrated oil production testing phase. Currently, domestic and overseas oilfields are still adopting the traditional oil production testing method, which contains plenty of repetitive processes that cost longer operating time, higher operating cost, formation damage caused by excessive high-density fluid, and many other shortcomings. Also, the difficulties of oil production testing in the deep and ultra-deep well under HPHT conditions are significant. Analyzing the development trend of oil production testing, there are two main topics identified: oil production testing for separated layer via one trip string and Pad-free oil production testing method. The oil production testing for separated layer via one trip string was developed for testing formations where lamination and thin layers are presented and causing interference among the testing layers. The Pad-free oil production testing methodology was developed for testing wells that fail to obtain reservoir fluid properties due to the formation damage caused by a high fluid density pad.
This paper is aiming to summarize and analyze the most advanced oil production testing technology worldwide and innovations had been made to the oil production testing field, hopefully inspired researchers to develop possible future uses and further improvements in efficiency. Facing the challenges of low gas prices, only continuous innovation in technology and the upgradation of tools and equipment can achieve the goal of improving quality and increasing efficiency.
The multi-functional design of child safety seat based on user demands
Authors: Ming Shan , Meng Kaining , Zhong Yuli 
Published: February 2021

With the improvement in laws and regulations related to children's passenger car safety and full implementation of the two-child policy in China, more and more people are going to be paying attention to child safety seats. Therefore, there will be a huge market for child safety seats of China in the future.
The child safety seats withe the single function of ensuring security can no longer meet the needs of parents and children, the multi-function complex product is becoming the development mainstream gradually. And they even began to pursue appearance molding of products. Most child safety seats on the market have only one function, which can be used in specific scenarios-cars, and after purchase, low frequency of use leads to increased cost. A multi-functional child safety seat is needed to meet the more advanced and increasingly diverse needs of users on this account.
This research not only takes the needs of users in different scenarios as the entry point for the design, takes the multi-function of child safety seats as the subject, and combines the behavior and psychology of the user population of relevant disciplines such as ergonomics and design psychology, but also analyzes the potential and obvious needs of the user population for child safety seats, and optimizes the existing child safety seats on the market from the aspects of child safety seat functions and appearance, so as to further meet the modern higher level of demand for child safety seats.
Research on Chinese-character Image Streaming based on the Digital-Streaming Media Technology
Authors: Liu Lin , Wang Jiaxin 
Published: February 2021

The survival mode of the font design has been changed to the mode of imaging design by the new-media technology. The Chinese character image could achieve different image effects of fonts including flow, page turning, rotation, and scrolling. Streaming media technology achieve the streaming playing approach to discuss the composition and dynamic effect of Chinese character image streaming.
Based on the characteristics of digital-streaming media, particle and fluid technology, and Chinese character image streaming, this paper will analyze and sort out the formation and techniques of Chinese character image based on streaming media technology.
This paper proposed the new concept of ‘Chinese character image streaming’. Since there is no systematic theories and no summarized experience about the practical works regarding the Chinese character image streaming, this paper compared and analyzed this new concept with above-mentioned technologies to provide new materials for the researches of Chinese character designs in the future.
Innovative design of campus green spaces in the context of the "One Belt, One Road" and the digital use of Silk Road elements
Authors: Jiang Weile , Zou Mingcong 
Published: February 2021

In recent years, the strategic development concept of “the Belt and Road Initiative” has been put forward in China, which brought new significance and connotation to the development of “Silk Road” in this era of globalization, digitalization and knowledge. As the starting point of the Silk Road, Xi 'an is also an international cultural metropolis that is further building and promoting economic prosperity and development. This special location has entrusted its unusual historical task. As the campus of Xi 'an Jiaotong University, the scientific and Technological Innovation Port in western China, located in Xi 'an, needs the rendering and influence of Silk Road culture. Therefore, in order to make teachers and students consciously inherit and appreciate the Silk Road culture, it is of great significance to make the diversity of the Silk Road culture reflect on the campus and create a unique campus landscape.
The paper is divided into five chapters. Firstly, it summarises the development of Silk Road culture from different dimensions such as era, level and region, extracts different categories of elements, summarises them with the analysis of the research of Suzhou Silk Museum, and discusses how to apply these elements to campus landscape design. Take the landscape of the green space in the east part of the Innovation Port as a design sample, combine with the field investigation and analysis, further outline the shape, path, colour, material and plant elements, follow the principles and principles of campus landscape design, enumerate the plant elements with data, explore new application methods, define the design concept with characteristics, from the road, culture and ecological landscape configuration, characteristic silk road culture elements in the whole site. In this way, the Silk Road culture can be inherited, history can embrace the future, and a distinctive campus landscape can be created that adapts to the new trends of the times.
Diagnose und zielgerichtete Therapie der Fournier-Gangrän mit septischem Verlauf: Vorstellung eines Behandlungsalgorithmus, Identifikation von Risikofaktoren, Betrachtung des Mikrobioms und Abgleich mit der Literatur
Authors: Wöhler Aliona , Schwab Robert , Güsgen Christoph , Schaaf Sebastian , Weitzel Carolin , Jänig Christoph , Willms Arnulf 
Published: February 2021

ZusammenfassungHintergrund Die Fournier-Gangrän ist eine nekrotisierende Fasziitis Typ I der genitalen und perinealen Regionen, die insbesondere bei schweren Verläufen und systemischer Sepsis mit einer hohen Letalität vergesellschaftet ist. Der Schwerpunkt wurde auf die Evaluation der Risikofaktoren und Komorbiditäten, auf das bakteriologische Spektrum, laborchemische Analysen, Mortalität und den Verlauf nach dem algorithmischen Vorgehen gelegt.Material und Methoden Es wurden 10 Patienten am Bundeswehrzentralkrankenhaus Koblenz im Zeitraum von 2010 bis 2019 mit einer Fournier-Gangrän und Sepsis sowie einer mindestens 48-stündigen Intensivtherapie erfasst und deskriptiv analysiert.Ergebnisse Die Patientenkohorte bestand aus 6 männlichen und 4 weiblichen Patienten mit einem Durchschnittsalter von 62 Jahren (Range 42 – 78 Jahre). Der durchschnittliche Zeitpunkt zwischen Auftreten der Beschwerden und der Krankenhausaufnahme betrug 4 Tage (Range 3 – 5). Die häufigste Genese war ein Bagatelltrauma bei bestehender entgleister Diabeteserkrankung (30%). Diabetes mellitus (60%) und Adipositas (80% mit BMI > 25) waren führende Risikofaktoren. Bei 90% der Patienten bestand eine polymikrobielle Besiedlung. Alle Patienten wiesen eine Multiorgandysfunktion auf und hatten einen SOFA-Score zwischen 3 und 17 Punkten. Die Mortalitätsrate betrug in unserem Patientenkollektiv 40%. Signifikante Unterschiede zwischen überlebenden und verstorbenen Patienten zeigten PCT, INR und aPTT (p < 0,05).Schlussfolgerung Die Fournier-Gangrän ist insbesondere bei septischem Verlauf nach wie vor eine Erkrankung mit hoher Letalitätsrate. Bei foudroyantem Verlauf bedarf es einer unmittelbaren Diagnosestellung sowie eines aggressiven operativen Vorgehens, um die Letalität so gering wie möglich zu halten. Nach initialem radikalem Débridement sowie stabilisierenden intensivmedizinischen Maßnahmen folgen weitere operative Eingriffe. In der postakuten Phase hat sich die Anwendung der Vakuumtherapie zur Defektverkleinerung bewährt.
An Overview of Computational Fluid Dynamics Preoperative Analysis of the Nasal Airway
Authors: Xavier Rui , Menger Dirk-Jan , de Carvalho Henrique Cyrne , Spratley Jorge 
Published: February 2021

AbstractEvaluation of the nasal airway is crucial for every patient with symptoms of nasal obstruction as well as for every patient with other nasal symptoms. This assessment of the nasal airway comprises clinical examination together with imaging studies, with the correlation between findings of this evaluation and symptoms reported by the patient being based on the experience of the surgeon. Measuring nasal airway resistance or nasal airflow can provide additional data regarding the nasal airway, but the benefit of these objective measurements is limited due to their lack of correlation with patient-reported evaluation of nasal breathing. Computational fluid dynamics (CFD) has emerged as a valuable tool to assess the nasal airway, as it provides objective measurements that correlate with patient-reported evaluation of nasal breathing. CFD is able to evaluate nasal airflow and measure variables such as heat transfer or nasal wall shear stress, which seem to reflect the activity of the nasal trigeminal sensitive endings that provide sensation of nasal breathing. Furthermore, CFD has the unique capacity of making airway analysis of virtual surgery, predicting airflow changes after trial virtual modifications of the nasal airway. Thereby, CFD can assist the surgeon in deciding surgery and selecting the surgical techniques that better address the features of each specific nose. CFD has thus become a trend in nasal airflow assessment, providing reliable results that have been validated for analyzing airflow in the human nasal cavity. All these features make CFD analysis a mainstay in the armamentarium of the nasal surgeon. CFD analysis may become the gold standard for preoperative assessment of the nasal airway.
Global inequities and political borders challenge nature conservation under climate change
Authors: Titley Mark A. , Butchart Stuart H. M. , Jones Victoria R. , Whittingham Mark J. , Willis Stephen G. 
Published: February 2021

Significance
Ecological communities are undergoing a major redistribution as species track their moving climatic niches on a warming planet. This has major repercussions for global biodiversity governance. By simulating the changing distributions of species under climate change, and comparing impacts between nations, we highlight the global inequities in climate impacts on nature. We then consider the global importance of transboundary conservation under climate change, as many species ranges are projected to move across political borders. By mapping transboundary range shifts globally, we highlight regions where international cooperation may be most useful for conservation and where border barriers may be most detrimental. Our findings underscore the need for cooperation across national boundaries to minimize biodiversity loss in the face of global change.
Entropic formation of a thermodynamically stable colloidal quasicrystal with negligible phason strain
Authors: Je Kwanghwi , Lee Sangmin , Teich Erin G. , Engel Michael , Glotzer Sharon C. 
Published: February 2021

Significance
Quasicrystals––ordered crystals lacking translational periodicity––occur in systems comprising building blocks ranging from atoms to nanoparticles. These quasicrystals can have the same structure despite the obvious differences in building-block type or size. Do they all form in the same way? Or do colloidal quasicrystals grow differently than atomic quasicrystals? We study the formation of a colloidal quasicrystal in a hard tetrahedron system, where structural ordering is solely governed by entropy. We observe that the colloidal quasicrystal forms with high structural quality when simulations begin in the melt. We also find that structural imperfections in approximant crystals can be repaired by the relaxation process observed during quasicrystal formation. This demonstrates that our quasicrystal is thermodynamically stable.
Global citation inequality is on the rise
Authors: Nielsen Mathias Wullum , Andersen Jens Peter 
Published: February 2021

SignificanceBy analyzing a global sample of 4 million authors and 26 million scientific papers, this study finds that the top 1% most-cited scientists have increased their cumulative citation shares from 14 to 21% between 2000 and 2015 and that the Gini coefficient for citation imbalance has risen from 0.65 to 0.70. The growing citation concentration should be understood in the context of diverging trends in publication and collaboration activities for the top 1% compared to the “ordinary scientist.” Our study raises intriguing questions about how rising inequalities will shape the evolution of science.
Torsional stress can regulate the unwrapping of two outer half superhelical turns of nucleosomal DNA
Authors: Ishida Hisashi , Kono Hidetoshi 
Published: February 2021

SignificanceThe torsional stress to chromatin structure plays an important role in eukaryotic cell where DNA-binding proteins such as RNA polymerase and chromatin remodeling complexes actively apply torsional stress. Under torsional stress, chromatin keeps balance between the integrity of the eukaryotic genome for storage of the genetic information and the accessibility of the DNA for gene expression. Using all-atom molecular dynamics simulations, we found that positive torsion facilitated asymmetric unwrapping of the DNA without a large extension of the DNA, while negative torsion suppressed unwrapping. Our results suggest that the stability of individual nucleosomes in chromatin can be changed or tuned by torsional stress, thereby DNA accessibility of regulatory proteins can be changed to regulate gene expression.
CD20 as a gatekeeper of the resting state of human B cells
Authors: Kläsener Kathrin , Jellusova Julia , Andrieux Geoffroy , Salzer Ulrich , Böhler Chiara , Steiner Sebastian N. , Albinus Jonas B. , Cavallari Marco , Süß Beatrix , Voll Reinhard E. , Boerries Melanie , Wollscheid Bernd , Reth Michael 
Published: February 2021

SignificanceWorldwide about one million patients are given anti-CD20 antibodies such as rituximab (RTX) for the treatment of B cell-associated diseases. Despite the success of this first therapeutic antibody, little is known about the function of its target. The role of CD20 only becomes clear in the context of the nanoscale compartmentalization of the B lymphocyte membrane. We found that CD20 is an organizer of the IgD-class nanocluster on the B cell membrane. The loss of CD20 on human B cells results in a dissolution of the IgD-class nanocluster and a transient B cell activation inducing a B cell-to-PC differentiation. Thus, CD20 is an essential gatekeeper of a membrane nanodomain and the resting state of naive B cells.