bluuebunny/crossref_metadata_2025_split huggingface dataset:
FUSTER-BEWAT SCORE VERSUS IDEAL CARDIOVASCULAR HEALTH SCORE TO PREDICT LEFT VENTRICULAR HYPERTROPHY: DATA FROM CHINA PEACE MILLIONS PERSONS PROJECT
Authors: Liu Lin , Huang Yuqing , Huang Jiayi , Chen Chaolei , Yu Yuling , Shen Geng , Feng Yingqing 
Published: April 2021

Abstract

Objective:
The Fuster-BEWAT Score (FBS) has been recently developed for use in lifestyle-based cardiovascular disease prevention, presenting similar accuracy in predicting subclinical atherosclerosis with ideal cardiovascular health score (ICHS), but it is unclear whether these scores exhibit comparable predictive values for detection of left ventricular hypertrophy (LVH). We evaluated the effectiveness of ICHS and FBS in assessing the presence of LVH among Chinese population.

Design and method:
A total of 3,521 participants aged 35 to 75 years with echocardiography screening in Guangdong were enrolled in the China PEACE (Patient centered Evaluative Assessment of Cardiac Events) Millions Persons Project. Subjects were grouped into three categories according to the number of favorable ICHS or FBS: ideal, intermediate, and poor. Left ventricular mass index (LVMI) was assessed by left ventricular mass divided by body surface area. LVH was defined as LVMI > = 115 g/m2 in male and LVMI > = 95 g/m2 in female.

Results:
In this study, poor ICHS accounts for 14.3% of all participants, intermediate ICHS 78.2%, and ideal ICHS 7.6%; poor FBS accounts for 4.4% of all participants, intermediate FBS 65.4%, and ideal FBS 30.2%. With poor ICHS as references, those with intermediate and ideal ICHS showed substantially lower adjusted odds of having LVH (odds ratio (OR) [95% confidence interval (CI)]: 0.643 [0.417, 0.991] and 0.346 [0.219, 0.547], respectively, with a p-value for trend < 0.001). Compared with participants with poor FBS, intermediate and ideal FBS were negatively associated with the likelihood of LVH (OR [95%CI]: 0.638 [0.512, 0.796] and 0.316 [0.211, 0.473], respectively, with a p-value for trend < 0.001). The Receiver Operating Characteristic Curve (ROC) indicated identical discriminating accuracy of ICHS (Area Under Curve (AUC): 0.696) and FBS (AUC: 0.702) with DeLong's test p-value 0.172 in identifying LVH.

Conclusions:
Both ICHS and FBS predict the presence and extent of subclinical atherosclerosis with similar accuracy, highlighting the value of the FBS as a simpler and more affordable score for evaluating the risk of LVH.
EFFECTS OF URIC ACID LOWERING THERAPY IN PATIENTS WITH PRIMARY HYPERTENSION
Authors: Gruszka Krystian , Rajzer Marek , Drozdz Tomasz , Czarnecka Danuta 
Published: April 2021

Abstract

Objective:
The aim of the study was to determine the effects of asymptomatic hyperuricemia (HU) treatment on selected Hypertension Mediated Organ Damage (HMOD) in patients with essential hypertension (EH).

Design and method:
We included 51 patients with stage 1–2 EH with newly diagnosed asymptomatic HU, on optimal, stable antihypertensive therapy, without coronary heart disease, symptomatic heart or renal failure.
Participants were randomly divided into two sub-groups: G1 (N = 27) and G2 (N = 24). Patients in both groups received the same dietary advice. In G1 we additionally started uric acid (UA) lowering therapy with allopurinol 100–300 mg/day. We measured blood pressure (BP) using office and 24-hour ambulatory blood pressure monitoring (ABMP), carotid-femoral pulse wave velocity (PWV), carotid artery intima-media thickness (IMT), performed echocardiography and blood tests including UA and NT-proBNP. All tests were repeated after 6 months.

Results:
UA lowering therapy in G1 was associated with a significant reduction in serum UA concentration (456 (414–488) vs. 310 (281–379) mmol/l, p < 0.001), while dietary advice alone (G2) did not cause significant reduction in serum UA concentration (406 (338–447) vs. 370 (345–401) mmol/l, p = 0.75). In G1 after 6 months of follow-up we observed significant reduction in left atrium volume (75 (58–97) vs. 72 (58–92) ml, p = 0.04), IMT thickness (0.81 (0.72–0.93) vs. 0.76 (0.72–0.89) mm, p = 0.03) and systolic office BP (141 (128–150) vs. 130 (123–136) mmHg, p = 0.03). UA lowering therapy after 6 months follow up did not affect 24-hour systolic BP (115 (105–125) vs. 112 (107–130) mmHg, p = 0.41), 24-hour diastolic BP (69 (63–76) vs. 70 (66–73) mmHg, p = 0.73), PWV (7.8 (6.9–8.7) vs. 7.7 (6.9–8.7) m/s, p = 0.45) and NT-proBNP levels (93 (51–227) vs. 114 (35–230) ng/l, p = 0.81).
In addition, allopurinol therapy at a higher dose than 00/day was associated with improved left ventricle global longitudinal strain (GLS): (-18.4 (-18.1;-21) vs. -18.9 (-18.4;-21.5) %, p = 0.02).
In G2 there were no significant differences in the tested parameters after 6 months.

Conclusions:
Our results may support the thesis that treatment of asymptomatic HU may lead to the reduction of some HMOD parameters (in particular left atrial enlargement and IMT thickness) and improve left ventricle GLS.
STRUCTURE AND GENDER DIFFERENCES IN COMORBIDITY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Kedelbaeva Kamilya , Berkinbaev Salim , Junusbekova Gulnar , Tundybayeva Mira , Kassimova Zarina 
Published: April 2021

Abstract

Objective:
To determine significant gender differences in the detection of comorbid pathology and to assess the role of comorbidity in the course of patients with myocardial infarction.

Design and method:
Statistical processing of the results was carried out using SPSS program using the methods of descriptive, parametric and non-parametric statistics. Numeric variables are generalized to their mean, standard deviation. The results are presented by the confidence interval (x ± confidence) for the average population with a normal distribution.

Results:
We performed a retrospective analysis of 500 patients. There were 325 men (65%); 175 women (35%), whose average age was 64.7 ± 1.03 years.
In the analysis, among patients with MI, comorbidity was revealed: in women, 30.6% had an average (2–3 diseases) and 41.1% high (4 or more diseases) comorbidity, while in men a combination of two or three nosological units was in 101 (30.9%), four - five and more in 90 (27.6%).
In almost all examined patients, 448 (89.6%) AMI developed against the background of arterial hypertension. Grade I hypertension was detected in 28 (6.3%), grade II hypertension - in 90 (20%), grade III hypertension - in 330 (73.7%).
129 (25.8%) patients had diabetes mellitus, CKD - in 118 (23.6%), COPD - in 97 (19.4%), gastrointestinal diseases - in 92 (18.4%), stroke was found in 58 (11.6%). Anemia was detected in 38 (7.6%), PE - in 7 (1.4%), DVT of the lower extremities - in 7 (1.4%).

Conclusions:
The vast majority of patients with a history of acute MI had comorbid pathology, more than half of them had 2–3 nosologies. Considering that 89.6% of patients had concomitant arterial hypertension, the influence of this factor on the clinical course of the disease cannot be excluded. Moreover, more than half of the patients with this concomitant pathology had a high degree of hypertension, which undoubtedly indicates an increase in the number of patients with hypertension and requires rational and timely antihypertensive therapy in this category of patients. The prevalence of comorbidity in women compared with men was determined; in women, more comorbidity in the structure was revealed.
ANALYSIS OF INTERRELATION BETWEEN COMORBID PATHOLOGY AND ANGIOGRAPHIC FEATURES OF CORONARY STREAM IN PATIENTS WITH MYOCARDIAL INFARCTION IN ALMATY CITY CARDIOLOGY CENTER
Authors: Kedelbaeva Kamilya , Oralbekova Zhanar , Berkinbayev Salim , Dzhunusbekova Gulnar , Tundybayeva Mira , Toilybaeva Madina 
Published: April 2021

Abstract

Objective:
The goal of the study is to determine the interrelation between comorbid pathology and angiographic features of the coronary stream.

Design and method:
Retrospective analysis of 500 clinical records of patients hospitalized at the Cardiology Center. The estimation of clinical diagnoses was carried out according to the rules of formulation and in accordance with ICD-10 revision. Statistical processing of results was performed in Microsoft Excel and Statistica Soft programs. The dependence of a parameter on one or more independent variables was revealed by means of regression analysis, where R-square (determination coefficient) and coefficients were taken into account. The higher the determination coefficient is, the higher the dependence is.

Results:
The age structure of the patients was determined: from 25 to 44 years old - 27,6% (138), from 44 to 60 years old, mainly about 2/3 of patients were over 60 years old.
Single vessel disease was found in 216 patients (43.2%), double vessel disease - in 111 patients (22.2%), three-vessel disease - in 66 patients (13.2%) and trunk disease - in 4 patients (0.8%). Taking into account the angiographic results, myocardial revascularization (balloon angioplasty and coronary artery stenting) was performed in 57.4% patients (287), coronary bypass surgery - 22% patients (110), and optimal medication therapy was recommended for 10.2% patients (51).
It was established that all patients with three-vessel coronary artery disease had comorbid pathology: 2–3 diseases were found in 32 patients (48.5%), comorbidity of 4–5 diseases – in 26 patients (39.4%), comorbidity of more than 5 diseases – in 8 patients (12.1%). The main structure of comorbidity in MI was determined: most frequently - 95.5% (63) arterial hypertension, 35% (23) - diabetes mellitus, 13.6% (9) - chronic obstructive pulmonary disease, 12% (8) - acute cerebrovascular event.
The data of linear regression analysis has revealed a reliable correlation between the combination of comorbid pathology and multivessel coronary artery disease among the investigated patients (R2 = 1).

Conclusions:
The correlation between the combination of comorbid pathology and multivessel coronary artery disease in patients with acute myocardial infarction in the cardiology center was established.
ASSOCIATION OF HYPERTENSION WITH QUALITY OF LIFE AND MEASURES OF MENTAL AND PHYSICAL HEALTH IN PATIENTS WITH RHEUMATIC DISEASES
Authors: Anyfanti Panagiota , Gavriilaki Eleni , Nikolaidou Barbara , Triantafyllou Areti , Papadopoulos Nikolaos , Aslanidis Spyros , Douma Stella , Gkaliagkousi Eugenia 
Published: April 2021

Abstract

Objective:
Increased prevalence of hypertension has been reported among patients with rheumatic diseases implicating autoimmune pathways and chronic inflammation. However, these patients commonly present mental health disorders, physical disability and impaired quality of life, which may as well interfere with hypertension. In the present study, we investigated the association of hypertension with quality of life and measures of mental and physical health in a large cohort of patients with rheumatic diseases.

Design and method:
Among consecutive patients attending the outpatient Rheumatology Clinic, health-related quality of life and anxiety were evaluated using the EuroQol 5D (EQ-5D) utility index and the Hamilton Anxiety Scale (HAM-A), respectively. The Health Assessment Questionnaire Disability Index (HAQ-DI), and the HAQ Pain Visual Analogue Scale (VAS-Pain) were used as measures of physical disability and arthritis-related pain, respectively. Hypertension was defined according to the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) guidelines.

Results:
A total of 464 individuals (81.7% females) with a mean age of 55.5 ± 13.8 years were included. Rheumatoid arthritis was the most common rheumatic disease (32.8%), followed by osteoarthritis (17.0%) and seronegative spondyloarthropathies (11.4%). Mean systolic/diastolic blood pressure (BP) was 130.3 ± 19.9/79.5 ± 10.5 mmHg and prevalence of hypertension reached 58.6% and. Patients with hypertension presented significantly higher HAM-A levels [16 (10–23) vs 13 (9–20.5), p = 0.014), higher HAQ-DI score (0.94 ± 0.79 vs 0.60 ± 0.61, p < 0.001), lower EQ-5D score (0.50 ± 0.24 vs 0.59 ± 0.24, p < 0.001), and higher VAS-pain [50 (25–75) vs 44.5 (10–70) %, p = 0.017], compared to normotensive patients. Multivariate analysis accounting for cardiovascular risk factors and disease-related parameters revealed an independent inverse association between systolic BP and quality of life (beta = –0.224, p = 0.022).

Conclusions:
Patients with rheumatic diseases and comorbid hypertension presented increased levels of anxiety, disability and pain and diminished quality of life compared to their normotensive counterparts. The association between BP and quality of life remained significant even after adjustment for other factors, revealing the complexity of the psycho-physical mode. Whether hypertension negatively affects quality of life in patients with chronic rheumatic disorders or vice versa impaired quality of life leads to increased BP, warrants further investigation.
ROS MEDIATED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY ATTENUATION BY MORIN: REGULATION OF RISK/SAPK PATHWAYS
Authors: Verma Vipin Kumar , Arya D.S. 
Published: April 2021

Abstract

Objective:
Morin, a bioflavonoid, has demonstrated anti-oxidant, anti-inflammatory and other diverse pharmacological protective activities in various experimental models. Oxidative stress plays an important role in the pathogenesis of myocardial ischemia reperfusion (IR) injury. Thus, this study aimed to evaluate the effect of Morin in Myocardial IR injury model and its underlying mechanism.

Design and method:
Male albino Wistar rats were divided into 5 groups. Sham; IR-Control; 2 Morin pre-treated groups (40 and 80 mg/kg; p.o.) and Morin perse group. The morin were administered for 28 days in respective group. On 29th day, rats were experienced 45 min myocardial ischemia following 60 min reperfusion except Sham and Morin perse groups. The cardioprotective potential was investigated via hemodynamic, biochemical, inflammatory marker investigations, cytokines levels, morphological analysis, immuno-histochemical analysis and protein expression estimation through multiplexed Immuno-blotting. The apoptotic markers were also investigate to analysed the programmed cell death due to oxidative stress.

Results:
With respect to IR-control group, Morin pre-treatment significantly normalized hemodynamic parameters, restored antioxidant status, improved pathological changes, reduced the release of cardiac injury markers, inhibited inflammation (TNF-alpha/IL-6/NF (kappa)B/IKK (beta) and apoptosis (increased Bcl-2, decreased Bax/Caspase-3 and TUNEL positivity) in the myocardium. This improvement in antioxidant, inflammation and anti-apoptosis markers could be due to downregulation of SAPK (p38/JNK) pathway and upregulation of survival kinase i.e. RISK pathway (ERK/eNOS) in the myocardium.

Conclusions:
IR induced oxidative stress leads to production of free radicals is attenuated by morin pretreatment for 28 days in rats which further reduced inflammation and apoptosis in the myocardium. This is the first experimental study which highlighted the role of SAPK/RISK pathways in morin induced cardio-protection in IR injury.
THE ROLE OF ADIPOKINES IN PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Papadopoulos Dimitrios , Sanidas Elias , Tsakalis Konstantinos , Velliou Maria , Zerva Kanella , Ntaliou Liana , Iliopoulos Dimitrios , Mantzourani Marina , Nikiteas Nikolaos , Barbetseas John 
Published: April 2021

Abstract

Objective:
Several adipose tissue bioactive factors (adipokines) have been linked to atherosclerosis, namely adiponectin, apelin and omentin-1 prevent atherosclerosis whereas resistin, visfatin and chemerin predispose to the development of coronary atherosclerotic plaques. The aim of this study was to calculate adipokines plasma levels in patients with and without angiographically established coronary artery disease (CAD) investigating any potential corellation between them and CAD.

Design and method:
Overall, 80 patients (40 with significant CAD and 40 without significant CAD) were studied. Adiponectin, apelin, omentin-1, resistin, visfatin and chemerin plasma levels were measured by the Elisa method.

Results:
Adiponectin, apelin and omentin-1 plasma levels were significantly lower in patients with CAD whereas visfatin, resistin and chemerin levels were significantly higher compared to those without CAD (Figure). No significant differences in demographic characteristics were observed between the two groups (Table).

Conclusions:
In patients with angiographically established CAD cardioprotective adipokines were lower while non-cardioprotective adipokines were higher indicating a direct relationship of these factors with the progression of atherosclerosis.
IN-HOSPITAL BLOOD PRESSURE VARIABILITY AS A PREDICTOR OF CARDIOVASCULAR EVENTS AND RENAL DYSFUNCTION IN THE SETTING OF ACUTE MYOCARDIAL INFARCTION
Authors: Mantzouranis M. , Tsioufis K. , Konstantinou K. , Kolokathis K. , Koumelli A. , Kalos T. , Kouremeti M. , Yfantis A. , Magkas N. , Fragoulis C. , Kasiakogias A. , Leontsinis I. , Tolis E. , Tousoulis D. 
Published: April 2021

Abstract

Objective:
Recent data have associated blood pressure variability (BPV) with cardiovascular morbidity and renal dysfunction but not in the setting of acute coronary syndrome (ACS). The aim of this study is to determine the impact short-term BPV on in-hospital cardiovascular outcomes and renal function in patients suffering a myocardial infarction (MI).

Design and method:
A total population of 250 MI patients (79.6% male; mean age 62.5 years;68.4% hypertensives)underwent 24-h ambulatory BP measurement during their hospitalization. The parameters of BPV analyzed were: a) 24-h standard deviation (SD), b) coefficient of variation (CV) and c) average real variability (ARV) of systolic and diastolic BP. The study population was divided intoa STEMI (n = 127) and a non-STEMI (n = 123) group. Cardiovascular outcomes included: new onset of ACS, pulmonary edema, hypertensive emergency, life threatening arrhythmias,whereas worsening of renal function (WRF) was defined as a reduction of GFR > or = 25% according to the RIFLE criteria. No deaths or strokes occurred.

Results:
In the total population a significant association was demonstrated between SBP CV andthe incidence of cardiovascular outcomes (OR = 1.136; 95% CI: 0.452–1.819; P = 0.001). After separate analysis for each MI group, SBP CV remained a predictor in the STEMI group (OR = 1.825; 95% CI: 0.814–2.835; P = 0.001). Regarding WRF CV SBP demonstrated a prognostic role (OR = 1.946; 95% CI:0.923–2.969; P < 0.001)in the entire population. Results for STEMI group were similar (OR = 3.769; 95% CI:2.056–5.481; P < 0.001). However, non-STEMI group failed to demonstrate any significant associations. We therefore, conducted multivariate regression models for STEMI group, in which the CV SBP retained predictive value of cardiovascular outcomes (OR = 1.502; 95% CI:0.470–2.534; P = 0.005) and WRF (OR = 4.139; 95% CI:2.423–5.962; P < 0.001)independently of age, gender, history of hypertension, diabetes mellitus (DM), smoking and low-density lipoprotein (LDL-C).

Conclusions:
In the setting of STEMI, assessment of BPV using CV could have a prognostic role of in-hospital cardio-renal outcomes suggesting a clinical need for further individualization of BP regulation in the integrative ACS management.
PREVALENCE AND NATURE OF EXTRA-CORONARY ARTERIAL ABNORMALITIES IN PATIENTS WITH SPONTANEOUS CORONARY ARTERY DISSECTION VS. CONTROLS
Authors: Pappaccogli Marco , Lopez-Sublet Marilucy , Al-Hussaini Abtehale , Radhouani Ibtissem , Adlam David , Persu Alexandre 
Published: April 2021

Abstract

Objective:
Spontaneous Coronary Artery Dissection (SCAD) has been associated with a high prevalence of Fibromuscular Dysplasia (FMD) and other extra-coronary arterial abnormalities. However, the prevalence, severity and clinical relevance of these abnormalities is still unclear. The objectives of the current study were: (i) to assess extra-coronary arterial abnormalities by MRA in patients with SCAD compared to controls; (ii) to compare the performance of MRA vs. CTA.

Design and method:
All images were jointly analysed by a vascular medicine specialist and a radiologist blinded for subject status and characteristics. In addition to qualitative analysis of images, arterial tortuosity was assessed by number of angles > 45% and tortuosity index in the main vascular beds.

Results:
MRA from brain to pelvis was available for 166 patients with SCAD (97% women, age at diagnosis: 44.4 ± 7.8 years) and 42 healthy controls matched for age and gender. The prevalence of FMD in patients with SCAD was 30.7% vs. 9.5% in controls (p = 0.005). In the SCAD group, the most frequently affected vascular beds were renal (13.9%), cerebrovascular (12.0%) and iliac (10.8%) arteries. Only 22% of SCAD patients had FMD lesions in 2 or more arterial beds. Nine SCAD patients (5.4%) had aneurysms vs. one (2.4%) in the control group (p = 0.5). No case of arterial dissection was identified. The prevalence and degree of arterial tortuosity was similar in cases and controls, irrespective of measurement method or arterial bed. Finally, in 35 patients explored both by CTA and MRA, the performance of MRA for detection of extra-coronary arterial abnormalities was similar to that of CTA.

Conclusions:
Based on the current blinded analysis of a large series of fully explored patients with SCAD compared to controls: (i) extra-coronary FMD is three times more frequent in patients with SCAD than in apparently healthy controls; (ii) FMD associated with SCAD is less often multivessel and associated with less severe arterial manifestations than “classical” FMD; (iii) patients with SCAD are not prone to extra-coronary arterial tortuosity; (iv) the performance of MRA is similar to that of CTA for detection of extra-coronary abnormalities in patients with SCAD.
ATHEROSCLEROTIC CORONARY ARTERY DISEASE IN PATIENTS WITH CARDIOMETABOLIC SYNDROME: FROM THREE FUKUOKA UNIVERSITY REGISTRY IN JAPAN
Authors: Miura Shin-Ichiro , Ike Amane , Shiga Yuhei , Suematsu Yasunori , Iwata Atsushi 
Published: April 2021

Abstract

Objective:
Major coronary risk factors were included in aging, gender, family history, hypertension, diabetes, high cholesterol and smoking. Metabolic syndrome includes abdominal obesity, high blood pressure, high triglyceride (TG) and/or low high-density lipoprotein cholesterol (HDL-C) and diabetes. We determined the critical risk factors for the onset and progression of coronary artery disease (CAD).

Design and method:
We have been going on three Fukuoka University Registry in Japan to define the risk factors for primary and secondary prevention of atherosclerotic CAD: Coronary Computed Tomography Angiography (FU-CCTA) Registry, Coronary Intravascular Ultrasound (FU-IVUS) Registry and Quantitative Coronary Angiography (FU-QCA) Registry. We analyzed the data from three Registry.

Results:
First, HDL-C levels were most closely associated with the presence of CAD from the FU-CCTA registry, and we need to perform CCTA for suspected CAD patients with lower HDL-C levels under statin treatment. In addition, in the five groups classified according to the number of metabolic factors, the number of significantly coronary stenosed vessels was significantly increased as the number of metabolic factors increased. Second, we found that among CAD patients treated with statins, TG levels were associated with lipid-rich coronary plaques in females, but not in males according to the FU-IVUS Registry. TG levels may be more important indicators of residual risk after statin treatment in females than in males. Lastly, HDL-C < 40 mg/dl and low-density lipoprotein cholesterol (LDL-C) equal to or more than 100 mg/dl were even more strongly related to major adverse cardiac events in female patients, whereas the combination of LDL-C and HDL-C was not related to MACEs in male patients on the FU-QCA Registry.

Conclusions:
Although an increased metabolic factors induces more severe CAD and lower HDL-C and higher LDL-C induce the onset and progression of CAD, there may be gender differences in the significance of lipid profiles.