bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-Domain Signal Reconstruction of Vehicle Interior Noise Based on
Data-Driven Method
Authors: Cao Jiaqi , Wang Xiaolan , Wang Yansong , Li Zhuo , Yang Dongpo 
Published: March 2021

Background:
In the process of high-speed driving, there are many source signals that affect the ear noise of passengers in the car. It is important to obtain the reference signal of Active Noise Control (ANC) of the vehicle at high speed condition.

Objective:
This paper introduces a method to study the time-domain signal reconstruction of interior noise based on data-driven method.

Methods:
Based on the noise signal collected in a car, the key point signals affecting the interior noise are determined by the acoustic transfer path analysis method. Considering the time-varying characteristics of the noise signal and the complex nonlinear relationship of interior noise, a noise reconstruction model based on wavelet decomposition Radial Basis Function (RBF) neural network is established. And the BP neural network noise reconstruction model is set up to compare the reconstruction effect.

Results:
According to the reconstruction comparison, the average absolute error (0.0072) of the proposed algorithm model is smaller than the average absolute error of the noise reconstruction BP network model based on wavelet decomposition (0.0280), and the accuracy is improved by 74.29%. The average absolute error between the reconstructed value of RBF neural network and the real-value is smaller than that of BP neural network, and the error of the proposed model is less than 0.01. The method proposed in this paper can reconstruct the interior noise signal of vehicle accurately and effectively.

Conclusion:
This paper proposes a reconstruction model of vehicle interior noise signal based on wavelet decomposition RBF neural network algorithm driven by data-driven, and verifies the effectiveness of the algorithm with the real vehicle test data. The reconstruction method of RBF neural network based on data-driven wavelet decomposition provides a certain reference value for ANC to obtain high-precision reference signal.
Littérature Orale et Société. La Chanson 'Attention au SIDA' et la Vie Sociale en RD Congo
Authors: Mbwangi Mbwangi Julien 
Published: March 2021

La littérature est bel et bien un essai de construction d’un monde idéal. Ainsi, tout texte littéraire, quelle que soit sa nature est en miniature une construction mentale dans laquelle le réel est perçu comme palimpseste de l’imaginaire. Dans ce sens, les écrivains, les artistes, les musiciens ont une responsabilité face aux événements qui affectent leur environnement. Par leur esprit de projection, ils ont le pouvoir d’orienter le cours des événements. Luambo Makiadi Franco dont nous avons ana- lysé le texte est un exemple d’un auteur sensible qui, par son art, a donné une orientation objective devant un problème social. La littérature de ce point de vue constitue une loupe pour bien voir la société et l‘orienter.
MOTS CLÉS: LITTÉRATURE ORALE, SOCIÉTÉ, VIE SOCIALE, RESPONSABILITÉ, CONSTRUCTION, DÉCONSTRUCTION.
Literature is a construct that tests the possibilities of an ideal world. Thus, any literary text, whatever its nature, is in miniature a mental construct in which reality is perceived as a palimpsest of the imagination. In this way writers, artists and musicians have a responsibility to treat events that affect their environment. With their talent of projection, they have the power to direct the course of events. Luambo Makiadi Franco, whose text is the subject of analysis in this paper, is an example of a sensitive author, whose art has given us an intersubjective understanding of a social problem. In this type of work, literature is a magnifying glass through which society is examined and guided in a particular direction.
KEY WORDS : ORAL LITERATURE, SOCIETY, SOCIAL LIVE, RESPONSIBILITY, CONSTRUCTION, DECONSTRUCTION.
Competitividad de la fresa mexicana en el mercado estadounidense de 1992 a 2017
Authors: Arroyo Cossio Arturo Julian , Hernández Flores Alondra Alejandra 
Published: March 2021

Las exportaciones de fresa a nivel internacional han alcanzado un promedio de 457.703 t en los últimos 30 años; el 2012 fue el año más importante con 852.369 t exportadas en total. Para el 2013, el valor de estas exportaciones fue de USD 2.330.136, y entre 1983 y 2013, el promedio fue de USD 971.262. La producción de fresa en México ha incrementado debido a programas enfocados en el fomento de la agricultura y la aplicación de métodos de producción. En 2011, los mayores exportadores de fresa fueron España, EE. UU., Países Bajos, Bélgica y México. El principal destino de exportación fue EE. UU., que concentró el 96 % para complementar su demanda. Los datos de producción y exportación ubican a México en el segundo lugar de producción y el quinto lugar de exportación a nivel mundial. Este estudio tuvo por objetivo determinar la competitividad de la fresa mexicana en el mercado estadounidense y su comportamiento en comparación con otros países exportadores como España y EE. UU. Para medir la competitividad, se utilizó el índice de Balassa y el índice de grado de apertura en exportaciones, que señalaron una competitividad positiva. Sin embargo, se requiere mayor especialización para aumentar los niveles competitivos existentes.
A Natural Language Processing–Based Virtual Patient Simulator and Intelligent Tutoring System for the Clinical Diagnostic Process: Simulator Development and Case Study
Authors: Furlan Raffaello , Gatti Mauro , Menè Roberto , Shiffer Dana , Marchiori Chiara , Giaj Levra Alessandro , Saturnino Vincenzo , Brunetta Enrico , Dipaola Franca 
Published: March 2021

Background
Shortage of human resources, increasing educational costs, and the need to keep social distances in response to the COVID-19 worldwide outbreak have prompted the necessity of clinical training methods designed for distance learning. Virtual patient simulators (VPSs) may partially meet these needs. Natural language processing (NLP) and intelligent tutoring systems (ITSs) may further enhance the educational impact of these simulators.

Objective
The goal of this study was to develop a VPS for clinical diagnostic reasoning that integrates interaction in natural language and an ITS. We also aimed to provide preliminary results of a short-term learning test administered on undergraduate students after use of the simulator.

Methods
We trained a Siamese long short-term memory network for anamnesis and NLP algorithms combined with Systematized Nomenclature of Medicine (SNOMED) ontology for diagnostic hypothesis generation. The ITS was structured on the concepts of knowledge, assessment, and learner models. To assess short-term learning changes, 15 undergraduate medical students underwent two identical tests, composed of multiple-choice questions, before and after performing a simulation by the virtual simulator. The test was made up of 22 questions; 11 of these were core questions that were specifically designed to evaluate clinical knowledge related to the simulated case.

Results
We developed a VPS called Hepius that allows students to gather clinical information from the patient’s medical history, physical exam, and investigations and allows them to formulate a differential diagnosis by using natural language. Hepius is also an ITS that provides real-time step-by-step feedback to the student and suggests specific topics the student has to review to fill in potential knowledge gaps. Results from the short-term learning test showed an increase in both mean test score (P<.001) and mean score for core questions (P<.001) when comparing presimulation and postsimulation performance.

Conclusions
By combining ITS and NLP technologies, Hepius may provide medical undergraduate students with a learning tool for training them in diagnostic reasoning. This may be particularly useful in a setting where students have restricted access to clinical wards, as is happening during the COVID-19 pandemic in many countries worldwide.
An App-Based Parenting Program to Promote Healthy Energy Balance–Related Parenting Practices to Prevent Childhood Obesity: Protocol Using the Intervention Mapping Framework
Authors: Karssen Levie T , Vink Jacqueline M , de Weerth Carolina , Hermans Roel C J , de Kort Carina P M , Kremers Stef PJ , Ruiter Emilie L M , Larsen Junilla K 
Published: March 2021

Background
The family environment plays an important role in the development of children’s energy balance–related behaviors. As a result, parents’ energy balance–related parenting practices are important targets of preventive childhood obesity programs. Families with a lower socioeconomic position (SEP) may benefit from participating in such programs but are generally less well reached than families with a higher SEP.

Objective
This paper describes the application of the Intervention Mapping Protocol (IMP) for the development of an app-based preventive intervention program to promote healthy energy balance–related parenting practices among parents of children (aged 0-4 years) with a lower SEP.

Methods
The 6 steps of the IMP were used as a theory- and evidence-based framework to guide the development of an app-based preventive intervention program.

Results
In step 1, behavioral outcomes for the app-based program (ie, children have a healthy dietary intake, sufficient sleep, and restricted screen time and sufficient physical activity) and sociocognitive (ie, knowledge, attitudes, and self-efficacy) and automatic (ie, habitual behaviors) determinants of energy balance–related parenting were identified through a needs assessment. In step 2, the behavioral outcomes were translated into performance objectives. To influence these objectives, in step 3, theory-based intervention methods were selected for each of the determinants. In step 4, the knowledge derived from the previous steps allowed for the development of the app-based program Samen Happie! through a process of continuous cocreation with parents and health professionals. In step 5, community health services were identified as potential adopters for the app. Finally, in step 6, 2 randomized controlled trials were designed to evaluate the process and effects of the app among Dutch parents of infants (trial 1) and preschoolers (trial 2). These trials were completed in November 2019 (trial 1) and February 2020 (trial 2).

Conclusions
The IMP allowed for the effective development of the app-based parenting program Samen Happie! to promote healthy energy balance–related parenting practices among parents of infants and preschoolers. Through the integration of theory, empirical evidence, and data from the target population, as well as the process of continued cocreation, the program specifically addresses parents with a lower SEP. This increases the potential of the program to prevent the development of obesity in early childhood among families with a lower SEP.

Trial Registration
Netherlands Trial Register NL6727, https://www.trialregister.nl/trial/6727; Netherlands Trial Register NL7371, https://www.trialregister.nl/trial/7371.
CHEMICAL REACTION KINETICS OF 1,5-BIS (3'-ETHOXY-4'-HYDROXYPHENYL)-1,4–PENTADIENT-3–ONE SYNTHESIS WITH FOOD GRADE RAW MATERIAL
Authors: MUMPUNI ESTI , MULATSARI ESTI , PUWANGGANA AGUS , VICY SOLA FIDE 
Published: March 2021

Objective: This research aims to develop the 1,5-bis (3'-ethoxy-4'-hydroxyphenyl)-1,4-pentadient-3-one (EHP) synthesis method from ethyl vanilin with food-grade quality and determines the order reaction and formation reaction rate constant of EHP.
Methods: Synthesis of the EHP was carried out by reflux the starting material, ethyl vanillin (food grade) of various weights, acetone and hydrochloric acid as catalysts. The reflux results are then condensed for two days at cold temperatures. Determination of the reaction order and reaction rate constants are carried out by the graph method based on the reduction in the concentration of ethyl vanilin, which reacts with acetone each time unit.
Results: The results showed the formation of EHP, which was synthesized by starting material of ethyl vanilin food grade 4 and 8 grams following pseudo-first-order reaction kinetics with reaction rate constants respectively 0,0116/minute and 0,005/minute. The formation of EHP, which was synthesized by starting material ethyl vanilin food grade 16 and 18 grams following zero-order reaction kinetics with reaction rate constants respectively 0,1451 mg/ml minute and 0,248 mg/ml minute.
Conclusion: The synthesis of EHP from ethyl vanilin with food-grade quality has been success develop. The order reaction kinetics are different in the different mass of ethyl vanillin used.
DEVELOPMENT AND CHARACTERIZATION OF PRECIROL ATO 88 BASE IN NANOSTRUCTURED LIPID CARRIERS (NLC) FORMULATION WITH THE PROBE SONICATION METHOD
Authors: JAFAR GARNADI , ABDASSAH MARLINE , RUSDIANA TAOFIK , KHAIRUNISA RIZKI 
Published: March 2021

Objective: Adapalene is a medicinal ingredient that can be used to treat acne. Adapalene has a Log P value of 8.6 and has high lipophilic and low solubility in water and is potentially degraded. Adapalene NLC can increase biphasic drug penetration at low doses but has good reactivity and provides occlusive properties that can increase skin hydration, thereby accelerating acne treatment.
Methods: Forming Adapalene NLC using the method of heat homogenization followed by ultrasonication probe. The NLC formulas used were Precirol ATO5 ®4.0%, Myritol ® 2%, Cremophor RH 40 1%, Plantacare 1%, Tegocare 1%, and Adapalene 0.3%. Following that is the characterization of particle size, polydispersity index, zeta potential, efficiency entrapment.
Results: The results showed the measurement of particle size with a range (150-318 nm), index polydispersion showed (0.12-0.36) and zeta potential (-26)-(-60 mV) and efficient entrapment testing showed results (84-98 %). In the TEM morphological evaluation of images showing spherical and evenly distributed forms, this is in line with the results of the adapalene NLC characterization.
Conclusion: These results suggest that NLC containing adapalene showed excellent result.
PHYSICAL PROPERTIES AND RATE OF DIFFUSION TRANSETHOSOME CURCUMIN USING A COMBINATION OF TWEEN 60 AND SPAN 60 AS SURFACTANT
Authors: AMALIA ANISA , SRIFIANA YUDI , ANWAR AMALIA 
Published: March 2021

Objective: Curcumin penetration can be increased by formulating it into the transethosome system. Surfactant is one of the transethosome components that affect the physical properties and penetration of vesicles. In this study, a combination of two surfactants was used to see the effect of surfactants on physical properties and curcumin penetration.
Methods: This study used a combination of tween 60 and span 60 with a concentration ratio of 0:5 (F1), 1:1 (F2), 2:1 (F3), and 1:2 (F4). An evaluation included testing the distribution of particle size, zeta potential, and entrapment efficiency in the system. Evaluation continued with the determination of the diffusion rate in vitro.
Results: The transethosome system formed has a particle size of 167.9±4.7 nm-396±3.7 nm with a potential zeta value (-) 49.54±1.77 mV-(-) 59.05±0.95 mV, polydispersion index 0.0%-57.1% and entrapment efficiency of 83.76%-93.75%. The diffusion rate of F1 and F3 followed the Higuchi kinetics model, while F2 and F4 followed zero-order kinetics and the Korsmeyer-Peppas kinetics.
Conclusion: The combination of tween 60 and span 60 could form a nano-sized transethosome of curcumin. Diffusion rate testing results show that using a surfactant combination can increase the diffusion rate of curcumin, where there is a significant difference between each formula (p<0.05).
DEVELOPMENT AND VALIDATION METHOD OF CYCLOPHOSPHAMIDE AND 4-HYDROXYCYCLOPHOSPHAMIDE WITH 4-HYDROXYCYCLOPHOSPHAMIDE-D4 AS INTERNAL STANDARD IN DRIED BLOOD SPOTS USING UPLC-MS/MS
Authors: HASANAH YESI IHDINA FITYATAL , HARAHAP YAHDIANA , SURYADI HERMAN 
Published: March 2021

Objective: Cyclophosphamide (CP) is anticancer of the alkylating agent (nitrogen mustard) and a prodrug which will be metabolized into an active metabolite form, 4-hydroxycyclophosphamide (4-OHCP). Therefore, the effectiveness of therapy with CP is determined by its metabolites concentration. The purpose of this study was to obtain a validated analytical method of CP and 4-OHCP simultaneously and sensitively in dried blood spots with SIL (Stable Isotope Labeled) 4-OHCP-d4 as the internal standard using liquid chromatography-tandem mass spectrometry, so optimization and full validation are conducted in this research.
Methods: A simpler analytical method was developed and validated to quantify CP and 4-OHCP in DBS samples using an Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS). A linear regression was used as the statistical analysis method. Sample preparation was performed by protein precipitation using methanol. The separation was performed on UPLC H-Class BEH C18 column using formic acid 0.01%-acetonitrile as the mobile phase in gradient mode at 0.2 ml/minute. The mass detection was performed on Waters Xevo TQD using ESI+for CP, 4-OHCP-SCZ, and IS 4-OHCP-d4-SCZ with m/z value: 261.03>140.16; 334.10>221.04; and 338.10>225.06.
Results: This method was linear within the range of 10–40,000 ng/ml for CP and 5–4,000 ng/ml for 4-OHCP. Lower Limit of Quantification (LLOQ) concentration of CP was 10 ng/ml and 4-OHCP was 5 ng/ml.
Conclusion: This method has successfully fulfilled the validation requirement referring to the 2011 EMA and 2018 FDA guidelines.
A NEW HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE SEPARATION AND SIMULTANEOUS QUANTIFICATION OF EPTIFIBATIDE AND ITS IMPURITIES IN PHARMACEUTICAL INJECTION FORMULATION
Authors: GIRIJA K. SRI , KASIMALA BIKSHAL BABU , ANNA VENKATESWARA RAO 
Published: March 2021

Objective: The objective of the present study is to develop a stability-indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method for qualitative and quantitative determination of Eptifibatide and its impurities in bulk and pharmaceutical dosage forms.
Methods: The chromatographic separation was carried on Phenomenex Luna C18 column (250 mm×4.6 mm; 5µ id) as stationary phase, methanol and phosphate buffer at pH 6.4 in the ratio of 65:45 (v/v) as mobile phase at flow rate of 1.0 ml/min, Ultra Violet (UV) detection was carried at the wavelength of 236 nm and the analysis was completed with a run time of 15 min.
Results: In the developed conditions, the retention time of Eptifibatide and its impurities 1 and 2 were found to be 3.35, 4.93 and 8.18 min, respectively. The method was validated for system suitability, range of analysis, precision, specificity, stability and robustness. Spiked recovery at 50%, 100% and 150% was carried for both standard and impurities and the acceptable % recovery of 98-102 was observed for Eptifibatide and both impurities studied and the % Relative standard deviation (RSD) in each spiked level was found to be less than 2. Stability tests were done through the exposure of the analyte solution to five different stress conditions i. e expose to 1N Hydrochloric acid (HCl), 1 N Sodium hydroxide (NaOH), 3% Hydrogen peroxide (H2O2), 80 °C temperature to UV radiation. In all the degradation conditions, standard drug Eptifibatide was detected along with both the impurities studied and the degradation products were successfully separated. In the formulation analysis, there is no other chromatographic detection of other impurities and formulation excipients.
Conclusion: The developed method was found to be suitable for the quantification of Eptifibatide and can separate and analyse impurities 1 and 2.
BINGE EATING DISORDERS; UPDATED AND EMERGING APPROACHES
Authors: TEAIMA MAHMOUD , HAMID MAGDI M. ABDEL , SHOMAN NABIL A. , JASTI BHASKARA R. , EL-NABARAWI MOHAMED A. , YASSER MOHAMED 
Published: March 2021

Objective: Binge eating disorders (BED) recently become a global health care issue for clinicians with detrimental effects on all organ systems. A multidisciplinary strategy including pharmacotherapy is required for its management.
Methods: This review is intended to comparatively evaluate the relative efficacy of different pharmacological agents in BED treatment with new therapeutic approaches, focusing on the clinical evidence and on Phase III randomized controlled trials.
Results: Data suggest that certain treatments have advantages over placebos to reduce binge eating features; however, the small duration of such research with the lack of adequately sized trials was the major limitation in interpreting these findings. Furthermore, these medications are mostly not greatly efficient for BED associated with obesity except for topiramate, which markedly improves the features of binge episodes with weight loss. Till now, lisdexamfetamine is still the only drug with regulatory permission for BED therapy; however, its weight loss efficacy has not been established.
Conclusion: Drugs alone or in combination approaches may be useful pharmacotherapies to yield promising outcomes acutely and over longer-term follow-up in the treatment of BED.
SILVER NANOPARTICLES AND COCONUT OIL INCORPORATED BIOPOLYMER BASED ELECTROSPUN NANOFIBERS FOR WOUND DRESSING
Authors: SAHOO SUBHASHREE , TRIPATHY JOGABRATA , MOIN AFRASIM , S. MEENAKSHI , SIDDARAMAIAH  , GOWDA D.V. 
Published: March 2021

Objective: The main aim of this study was to develop and evaluate the nanofiber loaded with coconut oil and silver nanoparticles (Ag NPs) for the treatment of wound healing by the electrospun method.
Methods: The nanofibers have been created using the reduced form of silver nanoparticles and coconut oil along with Eudragit L-100 by the electrospun method. The presence of coconut oil and chemical interaction was determined by the FTIR method. XRD was made to evaluate the crystalline nature of AgNPs and Eudragit L-100. TEM was carried out to show the presence of AgNPs on the surface of nanofibers and SEM represents the diameter of the fiber. The antibacterial activity of nanofibers was carried out using a disk diffusion assay.
Results: The diameter of the fibers was diminished by the excess of AgNPs in the fibers, while it increases by the coconut oil concentration, enhancing the nanofiber's hydrophilicity. FTIR spectroscopy was found in the range of coconut oil at 3553 cm-1for O-H stretch, 1365 cm-1, and 1240 cm-1 for the C-O stretch of ester groups. The diffraction peaks at 2θ of 38.5°, 44.6°, and 64.7°, in the XRD spectra of nanofiber, changed with silver NP affirming the total decrease of Ag salt. The bactericidal activity has been carried out between Escherichia coli and Staphylococcus aureus showing zones of inhibition of 20.0±0.2 mm and 14.8±0.4 mm, exhibiting excellent bactericidal characteristics for wound healing.
Conclusion: The formulated nanofibers were obtained to offer protection against external agents and help in the regeneration of new tissue.