bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern approaches to the protection of scientific and technical information as a result of intellectual creative activity
Authors: Dorozhko Hryhorii , Romashko Alla , Kravets Liudmyla , Poladko Oksana 
Published: September 2021

Keywords: scientific and technical information, intellectual property, trade secret,invention, utility model, rationalization proposal, WIPO PROOF, management system
The article is devoted to defining terms for information inorder to use it effectively. New scientific and technical information is particularlyhighlighted. It is of particular value for commercialization processes. Objects of newinformation that may be objects of intellectual property rights are highlighted. It isshown that there are inconsistencies in the legislation of Ukraine regarding these objects.This applies to such objects as know-how, trade secrets, and innovation proposals.Unclear definitions of them as objects of intellectual property rights effect the effectiveness of their use. This will affect their sharing and the transfer of rights tothird parties.The problem of protecting new information is particularly investigated. The dangerof its illegal use arises already at the stage of creation. The analysed practice ofprivacy violations has shown this. The main reason that was identified is the lack ofcompetence of those who have access to it. This is especially true for information thatis subject to intellectual property rights. Many of them have poor knowledge of themethod of checking for patent purity and approaches to determining secrecy.A method for using WIPO PROOF is proposed. It allows you to confirm the existenceof an information file of a particular author at the time of its registration. Thearticle shows the possibility of using the ISO9001: 2015 and ISO/IES 27001 standardsBy the ISO/IES 270001 standard “Information technology — Securitytechniques — Information security management systems — Requirements” in 2019alone, the International Organization for Standards issued more than 67 thousandcertificates, which indicates its demand in the business environment.It was stated that in Ukraine it is necessary to resolve the issue of controversial informationproducts and actively use methods for its protection. Recommendationswere made to organizations on information resource management. This is the mainway to effectively develop them in modern conditions.
Video game in the system of intellectual property: the concept and features of legal protection
Authors: Kodynets Anatolii , Murashko Arsen 
Published: September 2021

Keywords: video game, intellectual property law, computer program, software, digitalinformation, electronic information, multimedia work, audiovisual work
The article is devoted to thestudy of the legal understanding of video games as an object of intellectual propertyrights. The author concludes that video games constitute digital information, whichgreatly facilitates their development, however, complicates the protection of intellectualproperty rights. There is a contradictory connection between the concepts of«electronic (digital) information», «audiovisual work», «computer program» and «literarywork», which establishes some uncertainty in the protection of video games,namely, what should be understood by these concepts in terms of law.The author found that the use of the latest technologies to improve the visual componentbrings the video game even closer to the game audiovisual object, which increasesthe complexity of the process of protection of intellectual property rights. However, thecurrent situation with the use of the term «computer program» in the context of protectionof intellectual property rights to video games does not cover all features of the latter,covering only the main program among the software recording and operation of thegame, such as audiovisual content. Therefore, there is a need to use the generalized conceptof «software» as opposed to the narrower concept of «computer program». In thiscase, in the absence of at least one of the characteristics of the multimedia work, the computerprogram should be referred to the scope of legal regulation of software.The author proposed to understand the video game as object of intellectual propertylaw in the following manner: multimedia work expressed in the form of digital(electronic) information, the principle of which is determined by the algorithms of thesoftware provided for installation in the memory of computer devices.In general, the digital nature of video games presupposes a revision of existing approachesto the protection of intellectual property rights, which may be aimed atweakening the regulatory function of the law where it is possible to regulate the relationshipby more flexible means.
Association Among Local Hemodynamic Parameters Derived From CT Angiography and Their Comparable Implications in Development of Acute Coronary Syndrome
Authors: Yang Seokhun , Choi Gilwoo , Zhang Jinlong , Lee Joo Myung , Hwang Doyeon , Doh Joon-Hyung , Nam Chang-Wook , Shin Eun-Seok , Cho Young-Seok , Choi Su-Yeon , Chun Eun Ju , Nørgaard Bjarne L. , Nieman Koen , Otake Hiromasa , Penicka Martin , Bruyne Bernard De , Kubo Takashi , Akasaka Takashi , Taylor Charles A. , Koo Bon-Kwon 
Published: September 2021

Background: Association among local hemodynamic parameters and their implications in development of acute coronary syndrome (ACS) have not been fully investigated.Methods: A total of 216 lesions in ACS patients undergoing coronary CT angiography (CCTA) before 1–24 months from ACS event were analyzed. High-risk plaque on CCTA was defined as a plaque with ≥2 of low-attenuation plaque, positive remodeling, spotty calcification, and napkin-ring sign. With the use of computational fluid dynamics analysis, fractional flow reserve (FFR) derived from CCTA (FFRCT) and local hemodynamic parameters including wall shear stress (WSS), axial plaque stress (APS), pressure gradient (PG) across the lesion, and delta FFRCT across the lesion (ΔFFRCT) were obtained. The association among local hemodynamics and their discrimination ability for culprit lesions from non-culprit lesions were compared.Results: A total of 66 culprit lesions for later ACS and 150 non-culprit lesions were identified. WSS, APS, PG, and ΔFFRCT were strongly correlated with each other (all p &lt; 0.001). This association was persistent in all lesion subtypes according to a vessel, lesion location, anatomical severity, high-risk plaque, or FFRCT ≤ 0.80. In discrimination of culprit lesions causing ACS from non-culprit lesions, WSS, PG, APS, and ΔFFRCT were independent predictors after adjustment for lesion characteristics, high-risk plaque, and FFRCT ≤ 0.80; and all local hemodynamic parameters significantly improved the predictive value for culprit lesions of high-risk plaque and FFRCT ≤ 0.80 (all p &lt; 0.05). The risk prediction model for culprit lesions with FFRCT ≤ 0.80, high-risk plaque, and ΔFFRCT had a similar or superior discrimination ability to that with FFRCT ≤ 0.80, high-risk plaque, and WSS, APS, or PG; and the addition of WSS, APS, or PG into ΔFFRCT did not improve the model performance.Conclusions: Local hemodynamic indices were significantly intercorrelated, and all indices similarly provided additive and independent predictive values for ACS risk over high-risk plaque and impaired FFRCT.
Numerical Simulation of Imported Sediment in a Stilling Basin
Authors: Wang Rui , Li Peng , Li Zhanbin , Han Jianchun , Zhu Yubin 
Published: September 2021

Sediment buildup at the bottom of a stilling basin can result in premature drainage of spillway structures and can even lead to dam failure in severe cases. Such failures pose ecological and human safety hazards to downstream areas. To evaluate the sudden discharge and potential dam failure associated with sediment buildup, we developed a two-dimensional two-phase flow simulation model built on a particle-based force balance equation. We compared the flow patterns and energy dissipation effects in the stilling basin at different inlet flows (2, 3, 4.5, and 6.75 m2/s), and the subsequent bottom deposition was compared across different sand discharge mass flow rates (0.1, 0.2, and 0.3 kg/s). The results show that the turbulent energy increased with the increasing inlet unit width flow rate. When more vortices were generated and the flow velocity was reduced significantly, the energy dissipation was more effective. The sediment deposition at the bottom of the stilling basin gradually increased with the decrease of inlet unit width flow and the decrease of the sediment mass flow rate. Meanwhile, at a fixed inlet shape, the change in inlet unit width flow had little effect on the maximum sedimentation height at the bottom of the basin. In addition, the average deposition rate at the bottom of the stilling basin was positively correlated with the inlet sedimentation concentration, and the correlation coefficient could be as high as 0.97. In this two-phase flow method, the error of the simulated value over the theoretical value was less than 10%. This simulation of sediment deposition at the bottom of the stilling basin provides a practical reference for dam managers.
Applicability of Accurate Ground Motion Estimation Using Initial P Wave for Earthquake Early Warning
Authors: Wang Zijun , Zhao Boming 
Published: September 2021

The earthquake early warning (EEW) system is capable of mitigating seismic hazards and reducing deaths, injuries, and economic losses. Although EEW approaches have already been developed worldwide, improving the accuracy and applicability is still controversial. Aiming at the ground motion estimation using the initial P wave, we investigated eight representative characteristic parameters, i.e., the peak measurements and integral quantities, using the database of the 2008 Wenchuan earthquake, where the aftershocks with the criteria that 4.0 ≤ Ms ≤ 6.5 and epicentral distance less than 150 km are analyzed. We established the relationships between the eight characteristic parameters and four ground motion parameters, respectively, based on which the estimation accuracy and reliability and the extent to which the increasingly expanding time windows could affect the estimates are analyzed accordingly. We found that the integral quantities could also be a robust estimator for peak ground acceleration (PGA), peak ground velocity (PGV), and spectral intensity (SI), while the peak measurement is more useful in estimating peak ground displacement (PGD). In addition, for estimating the ground motion of events with magnitudes less than 6.5, a 2-s window could effectively improve the estimation accuracy by approximately 11.5–18.5% compared with using a 1-s window, as the window increases to 3 s, the accuracy would further improve while the growth rate will be reduced to around 3.0–8.0%.
Comparison of the Cumulative Live Birth Rates of Progestin-Primed Ovarian Stimulation and Flexible GnRH Antagonist Protocols in Patients With Low Prognosis
Authors: Du Mingze , Zhang Junwei , Li Zhen , Liu Xinmi , Li Jing , Liu Wenxia , Guan Yichun 
Published: September 2021

ObjectiveTo compare the cumulative live birth rate (CLBR) of the progestin-primed ovarian stimulation (PPOS) protocol with that of the flexible GnRH antagonist protocol in patients with poor prognosis diagnosed per the POSEIDON criteria.MethodsThis was a retrospective cohort study. Low-prognosis women who underwent IVF/ICSI at the Reproductive Center of Third Affiliated Hospital of Zhengzhou University between January 2016 and January 2019 were included according to the POSEIDON criteria. The CLBR was the primary outcome of interest. The secondary outcome measures were the numbers of oocytes retrieved, 2PN embryos, available embryos and time to live birth.ResultsA total of 1329 women met the POSEIDON criteria for analysis. For POSEIDON group 1, the dosage of gonadotropin (Gn) was higher in the PPOS group than in the GnRH antagonist group (2757.3 ± 863.1 vs 2419.2 ± 853.1, P=0.01). The CLBR of the PPOS protocols was 54.4%, which was similar to the rate of 53.8% in the GnRH antagonist group. For POSEIDON group 2, the number of available embryos was higher in the PPOS group (2.0 ± 1.7 vs 1.6 ± 1.4, P=0.02) than in the GnRH antagonist group. However, the CLBRs of the two groups were similar (18.1% vs 24.3%, P=0.09). For POSEIDON groups 3 and 4, there were no statistically significant differences in the number of oocytes retrieved, 2PN, available embryos or CLBR between the two protocols. After adjustments for confounding factors, the CLBR remained consistent with the unadjusted rates. In the POSEIDON group 1 population, the GnRH antagonist protocols had a shorter time to live birth (P=0.04).ConclusionFor low-prognosis patients diagnosed per the POSEIDON criteria, the CLBR of PPOS protocols is comparable to that of GnRH antagonist protocols. In the POSEIDON group 1 population, the GnRH antagonist protocols resulted in a shorter time to live birth.
Whole Exome Sequencing Uncovered the Genetic Architecture of Growth Hormone Deficiency Patients
Authors: Yu Chenxi , Xie Bobo , Zhao Zhengye , Zhao Sen , Liu Lian , Cheng Xi , Li Xiaoxin , Cao Bingyan , Shao Jiashen , Chen Jiajia , Zhao Hengqiang , Yan Zihui , Su Chang , Niu Yuchen , Song Yanning , Wei Liya , Wang Yi , Ren Xiaoya , Fan Lijun , Zhang Beibei , Li Chuan , Gui Baoheng , Zhang Yuanqiang , Wang Lianlei , Chen Shaoke , Zhang Jianguo , Wu Zhihong , Gong Chunxiu , Fan Xin , Wu Nan 
Published: September 2021

PurposeCongenital growth hormone deficiency (GHD) is a rare and etiologically heterogeneous disease. We aim to screen disease-causing mutations of GHD in a relatively sizable cohort and discover underlying mechanisms via a candidate gene-based mutational burden analysis.MethodsWe retrospectively analyzed 109 short stature patients associated with hormone deficiency. All patients were classified into two groups: Group I (n=45) with definitive GHD and Group II (n=64) with possible GHD. We analyzed correlation consistency between clinical criteria and molecular findings by whole exome sequencing (WES) in two groups. The patients without a molecular diagnosis (n=90) were compared with 942 in-house controls for the mutational burden of rare mutations in 259 genes biologically related with the GH axis.ResultsIn 19 patients with molecular diagnosis, we found 5 possible GHD patients received known molecular diagnosis associated with GHD (NF1 [c.2329T&gt;A, c.7131C&gt;G], GHRHR [c.731G&gt;A], STAT5B [c.1102delC], HRAS [c.187_207dup]). By mutational burden analysis of predicted deleterious variants in 90 patients without molecular diagnosis, we found that POLR3A (p = 0.005), SUFU (p = 0.006), LHX3 (p = 0.021) and CREB3L4 (p = 0.040) represented top genes enriched in GHD patients.ConclusionOur study revealed the discrepancies between the laboratory testing and molecular diagnosis of GHD. These differences should be considered when for an accurate diagnosis of GHD. We also identified four candidate genes that might be associated with GHD.
Interprofessional Communication Team for Caregivers of Patients Hospitalized in the COVID-19 Wards: Results From an Italian Experience
Authors: Carletto Sara , Corezzi Michele , Furmenti Maria Francesca , Olivero Elena , Rapicavoli Paola , Rossello Paola , Stanizzo Maria Rosa , Bovero Andrea 
Published: September 2021

Background: During the COVID-19 pandemic, emergency restrictions did not allow clinician family meetings and relatives' visits. In Molinette Hospital, a new communication model between healthcare providers and families of COVID-19 affected patients was developed by a team of physicians and psychologists. The study's aims were to investigate caregivers' distress and to analyse their satisfaction with the communications provided.Methods: A cross-sectional study was conducted among caregivers of patients of Molinette Hospital COVID wards. Between April and June 2020, all caregivers were contacted 2 weeks after the patient's discharge/death to assess their satisfaction with the communications received through an online survey.Results: A total of 155 caregivers completed the survey. Caregivers' distress level was found to be higher in women than men (p = 0.048) and in caregivers whose relative died compared to the caregivers whose relative was discharged (p &lt; 0.001). More than 85% of caregivers defined communication “excellent”/“very good”; being male was associated with higher satisfaction levels than women (β = −0.165, p = 0.046). Besides daily communication, 63 caregivers (40.6%) received additional support from a psychologist of the team.Conclusions: To our knowledge, this is the first study presenting, in an emergency, a new model of communication provided by a team of physicians and psychologists, and analyzing satisfaction with it. This model was highly appreciated by caregivers and it limited the discomfort caused by the restrictions on relatives' visits. It would be interesting to further evaluate the possibility of extending a communication model that includes doctors and psychologists in routine clinical practice.
RETRACTED: Multiple Sclerosis Recognition by Biorthogonal Wavelet Features and Fitness-Scaled Adaptive Genetic Algorithm
Authors: Wang Shui-Hua , Jiang Xianwei , Zhang Yu-Dong 
Published: September 2021

Aim: Multiple sclerosis (MS) is a disease, which can affect the brain and/or spinal cord, leading to a wide range of potential symptoms. This method aims to propose a novel MS recognition method.Methods: First, the bior4.4 wavelet is used to extract multiscale coefficients. Second, three types of biorthogonal wavelet features are proposed and calculated. Third, fitness-scaled adaptive genetic algorithm (FAGA)—a combination of standard genetic algorithm, adaptive mechanism, and power-rank fitness scaling—is harnessed as the optimization algorithm. Fourth, multiple-way data augmentation is utilized on the training set under the setting of 10 runs of 10-fold cross-validation. Our method is abbreviated as BWF-FAGA.Results: Our method achieves a sensitivity of 98.00 ± 0.95%, a specificity of 97.78 ± 0.95%, and an accuracy of 97.89 ± 0.94%. The area under the curve of our method is 0.9876.Conclusion: The results show that the proposed BWF-FAGA method is better than 10 state-of-the-art MS recognition methods, including eight artificial intelligence-based methods, and two deep learning-based methods.
Gut Microbiota Disorders Promote Inflammation and Aggravate Spinal Cord Injury Through the TLR4/MyD88 Signaling Pathway
Authors: Rong Zijie , Huang Yuliang , Cai Honghua , Chen Min , Wang Hao , Liu Guihua , Zhang Zhiwen , Wu Jiawen 
Published: September 2021

Background: In spinal cord injury (SCI), systemic inflammation and the death of nerve cells in the spinal cord are life threatening. The connection between gut microbiota and signaling pathways has been a hot research topic in recent years. The Toll-like receptor 4/Myeloid differentiation factor 88 (TLR4/MyD88) signaling pathway is closely related to the inflammatory response. This study explored whether the gut microbiota imbalance could affect the TLR4/MyD88 signaling pathway to regulate SCI to provide a new basis for SCI research and treatment.Methods: An SCI model was constructed to study the influence on the injury of gut microbiota. 16S amplicon sequencing was used to identify the diversity and abundance of gut microbes. Fecal microbiota transplantation was performed in mice with SCI. ELISA was used to detect the serum levels of pro-inflammatory and anti-inflammatory factors in mice. Hematoxylin and eosin staining was used to observe SCI in mice. Immunofluorescence was used to detect the rates of loss glial fibrillary acidic protein (GFAP), neuronal nuclear protein (NeuN), and ionized calcium-binding adapter molecule 1 (IBA1) in the spinal cord as indicators of apoptosis. The expression of the TLR4/MyD88 signaling pathway was detected by qRT-PCR and western blotting.Results: Significant differences were observed in the gut microbiota of SCI mice and normal mice. The gut microbiota of SCI mice was imbalanced. The levels of pro-inflammatory cytokines tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in SCI mice were increased, as was the level of the toxic induced nitric oxide synthase. The levels of anti-inflammatory factors IL-4, transforming growth factor-β, and IL-10 were decreased, as was the level of arginase-1. The apoptosis rates of GFAP, NeuN, and IBA1 were increased. The TLR4/MyD88 signaling pathway was activated. In the SCI group, inflammation increased after fecal transplantation, apoptosis of GFAP, NeuN, and IBA1 increased, and SCI was more serious.Conclusion: The TLR4/MyD88 signaling pathway promotes the death of nerve cells by inducing inflammation. Gut microbiota dysregulation can lead to aggravated SCI by activating the TLR4/MyD88 signaling pathway.
Neoadjuvant Chemotherapy Followed by Surgery Versus Abdominal Radical Hysterectomy Alone for Oncological Outcomes of Stage IB3 Cervical Cancer—A Propensity Score Matching Analysis
Authors: Li Weili , Zhang Wenling , Sun Lixin , Wang Li , Cui Zhumei , Zhao Hongwei , Wang Danbo , Zhang Yi , Guo Jianxin , Yang Ying , Wang Wuliang , Bin Xiaonong , Lang Jinghe , Liu Ping , Chen Chunlin 
Published: September 2021

ObjectiveTo compare the 5-year overall survival (OS) and disease-free survival (DFS) of patients with cervical cancer who received neoadjuvant chemotherapy followed by surgery (NACT) with those who received abdominal radical hysterectomy alone (ARH).MethodsWe retrospectively compared the oncological outcomes of 1410 patients with stage IB3 cervical cancer who received NACT (n=583) or ARH (n=827). The patients in the NACT group were divided into an NACT-sensitive group and an NACT-insensitive group according to their response to chemotherapy.ResultsThe 5-year oncological outcomes were significantly better in the NACT group than in the ARH group (OS: 96.2% vs. 91.2%, respectively, p=0.002; DFS: 92.2% vs. 87.5%, respectively, p=0.016). Cox multivariate analysis suggested that NACT was independently associated with a better 5-year OS (HR=0.496; 95% CI, 0.281-0.875; p=0.015), but it was not an independent factor for 5-year DFS (HR=0.760; 95% CI, 0.505-1.145; p=0.189). After matching, the 5-year oncological outcomes of the NACT group were better than those of the ARH group. Cox multivariate analysis suggested that NACT was still an independent protective factor for 5-year OS (HR=0.503; 95% CI, 0.275-0.918; p=0.025). The proportion of patients in the NACT group who received postoperative radiotherapy was significantly lower than that in the ARH group (p&lt;0.001). Compared to the ARH group, the NACT-sensitive group had similar results as the NACT group. The NACT-insensitive group and the ARH group had similar 5-year oncological outcomes and proportions of patients receiving postoperative radiotherapy.ConclusionAmong patients with stage IB3 cervical cancer, NACT improved 5-year OS and was associated with a reduction in the proportion of patients receiving postoperative radiotherapy. These findings suggest that patients with stage IB3 cervical cancer, especially those who are sensitive to chemotherapy, might consider NACT followed by surgery.