bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement of operative femoral anteversion during cementless total hip arthroplasty and influencing factors for using neck-adjustable femoral stem
Authors: Sun Jingyang , Zhang Bohan , Geng Lei , Zheng Qingyuan , Li Juncheng , Cao Wenzhe , Ni Ming , Zhang Guoqiang 
Published: May 2021

Abstract
Background
Placement of femoral stem in excessive anteversion or retroversion can cause reduced range of motion, prosthetic impingement, and dislocation. The aim of this study was to assess the operative femoral anteversion in patients treated with total hip arthroplasty (THA) and analyze the need of adjusting stem anteversion.

Methods
We retrospectively included 101 patients (126 hips) who underwent cementless THA with a manual goniometer to determine the femoral anteversion between October 2017 and December 2018. The operative femoral anteversion we measured was recorded during THA. We further divided those hips into three subgroups based on the range of operative femoral anteversion: group 1 (<10°), group 2 (10–30°), and group 3 (>30°) and compared the differences of their demographic data. Univariate and multivariate logistic regression were used to identify the influencing factors for the need of neck-adjustable femoral stem. The clinical and radiographic outcomes were also assessed. Perioperative complications were recorded.

Results
After THA, the Harris hip scores improved from 52.87 ± 15.30 preoperatively to 90.04 ± 3.31 at the last follow-up (p < 0.001). No implant loosening, stem subsidence, and radiolucent lines were observed on radiographs. No severe complications occurred and no components needed revision at the latest follow-up. The mean operative femoral anteversion was 14.21° ± 11.80° (range, −9 to 60°). Patients with femoral anteversion more than 30° were about 10 years younger than others. Femoral anteversion >30° was more common in patients with developmental dysplasia of the hip (DDH). There were totally 14 hips treated with the neck-adjustable femoral stem. From the univariate analysis, we can observe that female sex, diagnosis of DDH (compared with osteonecrosis), and higher operative femoral anteversion and its value >30° (compared with <10°) are associated with higher rates of using the neck-adjustable femoral stem. However, all these factors were no longer considered as independent influencing factors when mixed with other factors.

Conclusions
This study highlighted the significance of operative femoral anteversion. Identification of abnormal femoral anteversion could assist in adjusting stem anteversion and reduce the risk of dislocation after THA.
Pancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report
Authors: Haeberle Lena , Busch Melanie , Kirchner Julian , Fluegen Georg , Antoch Gerald , Knoefel Wolfram Trudo , Esposito Irene 
Published: May 2021

AbstractBackgroundMetastatic spread to the pancreas is a rare event. Renal cell carcinoma represents one possible site of origin of pancreatic metastases. Renal cell carcinoma often metastasizes late and exclusively to the pancreas, suggesting a special role of renal cell carcinoma among primaries metastasizing to the pancreas. Even rarer, renal cell carcinoma may occur simultaneously with pancreatic ductal adenocarcinoma.Case presentationWe present the case of a 78-year-old male Caucasian patient with a history of clear-cell renal cell carcinoma treated with oncological left nephrectomy 20 years before. The patient was diagnosed with pancreatic ductal adenocarcinoma by fine-needle aspiration cytology. At our institution, he received neoadjuvant therapy with folic acid, fluorouracil, irinotecan, oxaliplatin for borderline-resectable pancreatic ductal adenocarcinoma, and subsequently underwent total pancreatectomy. Upon resection, pancreatic ductal adenocarcinoma as well as two metachronous metastases of clear-cell renal cell carcinoma occurring simultaneously and cospatially with pancreatic ductal adenocarcinoma were diagnosed in the pancreatic body.ConclusionsRenal cell carcinoma metastases of the pancreas are rare and often occur decades after the initial diagnosis of renal cell carcinoma. The combination of renal cell carcinoma metastases and pancreatic ductal adenocarcinoma is even rarer. However, the possibility should be considered by clinicians, radiologists, and pathologists. The special role of renal cell carcinoma as a site of origin of pancreatic metastasis should be further elucidated.
Acute kidney injury in SARS-CoV2-related pneumonia ICU patients: a retrospective multicenter study
Authors: Geri Guillaume , Darmon Michael , Zafrani Lara , Fartoukh Muriel , Voiriot Guillaume , Le Marec Julien , Nemlaghi Saafa , Vieillard-Baron Antoine , Azoulay Elie 
Published: May 2021

AbstractBackgroundWhile acute kidney injury (AKI) is frequent in severe SARS-CoV2-related pneumonia ICU patients, few data are still available about its risk factors.MethodsRetrospective observational study performed in four university affiliated hospitals in Paris. AKI was defined according to the KIDGO guidelines. Factors associated with AKI were picked up using multivariable mixed-effects logistic regression. Independent risk factors of day 28 mortality were assessed using Cox model.Results379 patients (median age 62 [53,69], 77% of male) were included. Half of the patients had AKI (n = 195, 52%) including 58 patients (15%) with AKI stage 1, 44 patients (12%) with AKI stage 2, and 93 patients (25% with AKI stage 3). Chronic kidney disease (OR 7.41; 95% CI 2.98–18.4), need for invasive mechanical ventilation at day 1 (OR 4.83; 95% CI 2.26–10.3), need for vasopressors at day 1 (OR 2.1; 95% CI 1.05–4.21) were associated with increased risk of AKI. Day 28 mortality in the cohort was 26.4% and was higher in patients with AKI (37.4 vs. 14.7%,P < 0.001). Neither AKI (HR 1.35; 95% CI 0.78–2.32) nor AKI stage were associated with mortality (HR [95% CI] for stage 1, 2 and 3 when compared to no AKI of, respectively, 1.02 [0.49–2.10], 1.73 [0.81–3.68] and 1.42 [0.78–2.58]).ConclusionIn this large cohort of SARS-CoV2-related pneumonia patients admitted to the ICU, AKI was frequent, mostly driven by preexisting chronic kidney disease and life sustaining therapies, with unclear adjusted relationship with day 28 outcome.
Democratising utopian thought in participatory agenda setting
Authors: Gudowsky Niklas , Bechtold Ulrike , Peissl Walter , Sotoudeh Mahshid 
Published: May 2021

AbstractEngaging non-experts in matters of science and technology has been increasingly stressed in both rhetoric and action during the past decades. Under the call for moving participation upstream, agenda setting processes have been identified as viable entry point for laypeople’s experiential and value-based knowledge into science, technology and innovation governance (STI). Harnessing visioning for target setting promises to elicit such knowledge, whilst at the same time evading the dilemma of informing participants about STI that does not exist prior to engagement. To test such claims, we investigate a large-scale citizen-visioning exercise employed as an initiation of a transdisciplinary research and innovation agenda setting process, namely CIMULACT. In a comparable Europe-wide process, more than 1000 laypeople (citizens) produced 179 visions of desirable futures which built the basis for co-creating future research topics for advising the EU research and innovation programme Horizon 2020. We provide in depth insights into the visioning methodology for inclusion of citizens into STI agenda setting, and discuss room for methodological improvement regarding potential loss and gains of creativity and diversity of opinions considering empirical results of ex-post participant evaluation questionnaires (n ≈ 964). The discussed data shows a generally positive evaluation of the process and engagement, since citizens are in retrospective content with the process and visions, they would participate again in a similar event, and they are in favour of the EU to continue hosting such events in the future. However, citizens were rather sceptic whether the results actually (can/will) have an impact on the stated aim of integration in research and innovation agenda setting.
Irritable bowel syndrome in midlife women: a narrative review
Authors: Yang Pei-Lin , Heitkemper Margaret M. , Kamp Kendra J. 
Published: May 2021

AbstractMidlife women between the ages of 40 and 65 years have reported multiple challenges due to menopausal, developmental, and situational transitions from younger to older adulthood. During the midlife period, many women seek health care for gastrointestinal symptoms and irritable bowel syndrome (IBS). Multiple factors including stress, poor sleep, diet, and physical inactivity may contribute to IBS or gastrointestinal symptoms in midlife women. As such, a comprehensive assessment and treatment approach is needed for midlife women suffering gastrointestinal symptoms. This article reviews the main aspects of the menopausal transition, sex hormonal changes, abdominal and pelvic surgery, psychosocial distress, behavioral factors, and gut microbiome, as well as their relevance on IBS and gastrointestinal symptoms in midlife women. Also, management strategies for IBS in midlife women are discussed. To date, gastrointestinal symptoms during midlife years remain a critical area of women’s health. Additional research is needed to better understand the contributors to gastrointestinal symptoms in this group. Such efforts may provide a new window to refine or develop treatments of gastrointestinal symptoms for midlife women.
Patient reported physical and mental health changes associated with a comprehensive cardiovascular risk reduction program for women with breast cancer receiving potentially cardiotoxic chemotherapy
Authors: Fradley Michael G. , Alomar Mohammed , Kilpatrick Marcus W. , Shields Bernadette , Tran Nhi , Best Amey , Bianco Erika , Armanious Merna , Vautier R. Ashton , Kip Kevin , Beckie Theresa M. , Ismail-Khan Roohi 
Published: May 2021

Abstract
Objective
Women with breast cancer (BCA) and cardiovascular disease (CVD) risk factors are at increased risk of developing cardiovascular complications when exposed to potentially cardiotoxic cancer therapy. The benefit of aggressive CVD risk factor modification to reduce adverse treatment-related psychologic and biologic effects is not well established.

Methods
Using a single group pre-test, post-test design, 33 women with BCA receiving anthracycline and/or trastuzumab therapy participated in a 6-month comprehensive CVD risk reduction program involving formal cardio-oncology evaluation along with regular motivational counseling for improved nutrition and physical activity. Study parameters were assessed at baseline and 6 months with paired t-tests used to evaluate changes after the intervention.

Results
The mental component summary score assessed by SF-36V2 improved significantly after program completion (45.0 to 48.8, effect size 0.37, p = 0.017), however the physical component summary score declined (46.2 to 40.9, effect size − 0.53, p = 0.004). Despite this decline in perceived physical health, markers of health-related fitness and nutritional status were maintained or improved. Systolic and diastolic blood pressure also improved after the intervention (136.7 to 124.1 mmHg, p = 0.001 and 84.0 to 78.7 mmHg, p = 0.031, respectively). No significant change in resting heart rate, body mass index, lipids, hemoglobin A1C, or left ventricular ejection fraction was observed.

Conclusions
Patient-reported mental health improved significantly in women with BCA enrolled in a comprehensive CVD risk reduction program despite exposure to potentially cardiotoxic therapies. This study provides preliminary data for future randomized controlled trials evaluating the effects CVD risk reduction program in high-risk breast cancer cohorts.
Salt intake was higher among males and those with high BMI and waist circumference: introduction to the Malaysian Community Salt Survey (MyCoSS), a population-based salt intake survey in Malaysia
Authors: Ambak Rashidah , He Feng J , Othman Fatimah , Michael Viola , Mohd Yusoff Muhammad Fadhli , Aris Tahir 
Published: May 2021

Abstract
Background
Recognising that excessive dietary salt intake is associated with high blood pressure and adverse cardiovascular health, the Ministry of Health Malaysia conducted the Malaysian Community Salt Survey (MyCoSS) among Malaysian adults. This paper introduced MyCoSS projects and presented findings on the salt intake of the Malaysian adult population.

Methods
MyCoSS was a nationally representative survey, designed to provide valuable data on dietary salt intake, sources of salt in the diet, and knowledge, perception, and practice about salt among Malaysian adults. It was a cross-sectional household survey, covering Malaysian citizens of 18 years old and above. Multi-stage-stratified sampling was used to warrant national representativeness. Sample size was calculated on all objectives studied, and the biggest sample size was derived from the knowledge on the effect of high salt on health (1300 participants). Salt intake was estimated using a single 24-h urine collection and its sources from a food frequency questionnaire. Knowledge, attitude, and practice were determined from a pre-tested questionnaire. All questionnaires were fully administered by trained interviewers using mobile devices. Anthropometric indices (weight, height, and waist circumference) and blood pressure were measured using a standardised protocol. Ethical approvals were obtained from the Medical Research Ethics Committee, Ministry of Health Malaysia, and Queen Mary University of London prior to conducting the survey.

Results
Findings showed that the average sodium intake of Malaysian adults (3167 mg/day) was higher than the WHO recommendation of 2000 mg/day. Daily intake was significantly higher among males and individuals with higher BMI and higher waist circumference.

Conclusion
Salt intake in the Malaysian population was higher than the WHO recommendation. MyCoSS’s findings will be used for the development and implementation of national salt reduction policy. A successful implementation of a national salt reduction programme in Malaysia will benefit the whole population.
COVID-19 vaccination may cause FDG uptake beyond axillary area
Authors: Fleury Vincent , Maucherat Bruno , Rusu Daniela , Dumont Frédéric , Rousseau Caroline 
Published: May 2021

Abstract
Background
The vaccination immune response may induce false-positive 18F-FDG PET/CT uptake.

Case presentation
An extended supraclavicular lymph nodal activation after coronavirus disease 2019 (COVID-19) vaccination revealed on 18F-FDG PET/CT mimics a Virchow nodule in a patient with medical history of well-differentiated appendicular adenocarcinoma.

Conclusion
This case highlights a nodal activation beyond axillary area and the importance of documenting vaccination history at the time of scanning to avoid false-positive results.
Role of multidetector computed tomography in evaluation of resectability of pancreatic cancer
Authors: Azzaz Hossam Elsayed Mohammed , Abdullah Mohamed Shawky , Habib Rehab Mohammed 
Published: May 2021

Abstract
Background
Pancreatic cancer is one of the most significant causes and one of the most lethal malignant neoplasms in the world of cancer death in the developed nations. It was named the “silent killer” for its quiet course, late clinical presentation, and the trend of rapid growth. The aim of this study is to detect the reliability of multidetector CT (MDCT) as diagnostic tool in assessing the possibility of eradicating pancreatic cancer.

Results
Twenty-four patients (57%) were not suitable for surgery with non-resectable mass; the remaining eighteen patients (43%) were considered suitable according to MDCT criteria for surgical resection of the tumor. Fourteen out of the sixteen patients (87.5%) had a successful removal of the lump, while the remaining two cases (12.5%) during surgery, the mass was unresectable. The results of the pathology specimens showed that fourteen out of the fourteen patients (100%) had successful operation with no cancer cells in the margin, and a positive predictive value of 87.5% and accuracy of 89.47%.

Conclusions
The advancement of MDCT expertise improves the outcome of pancreatic cancer resectability.
Can DWI-MRI be an alternative to DCE-MRI in the diagnosis of troublesome breast lesions?
Authors: Hashem Lamiaa Mohamed Bassam , Gareer Sherihan W. Y. , Hashem Aya Mohamed Bassam , Fakhry Sherihan , Tohamey Yasmin Mounir 
Published: May 2021

AbstractBackgroundDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has always been a problem solver in troublesome breast lesions. Despite its many advantages, the encountered low specificity results in unnecessary biopsies. Diffusion-weighted MRI (DW-MRI) is a well-established technique that helps in characterizing breast lesions according to their water diffusivity. So this work aimed to assess the diagnostic performance of DW-MRI in troublesome breast lesions and see if it can replace DCE-MRI study.ResultsIn our prospective study, we included 86 patients with mammography and/or ultrasound-detected 90 probably benign or probably malignant (BIRADS 3 or 4) breast lesions. Among the studied cases, 49/90 lesions were benign, and 41/90 were malignant. Combined analysis of morphological and kinetic findings in DCE-MRI had achieved the highest sensitivity of 95.1%. DW-MRI alone was less sensitive (73.2%) yet more specific (83.7%) than DCE-MRI (77.6%). Diagnostic accuracy of DCE-MRI was higher (85.6%) as compared to DW-MRI which was (78.9%).ConclusionDCE-MRI is the cornerstone in the workup of troublesome breast lesions. DW-MRI should not be used as supplementary tool unless contrast administration is contraindicated. Combining both DCE-MRI and DW-MRI is the ultimate technique for better lesion evaluation.
Hepatic ischemia reperfusion injury: effect of moderate intensity exercise and oxytocin compared to l-arginine in a rat model
Authors: ELKady Amr H. , Elkafoury Bataa M. , Saad Dalia A. , Abd el-Wahed Doaa M. , Baher Walaa , Ahmed Mona A. 
Published: May 2021

Abstract
Background
Hepatic ischemia reperfusion (IR) injury is considered as a main cause of liver damage and dysfunction. The l-arginine/nitric oxide pathway seems to be relevant during this process of IR. Although acute intense exercise challenges the liver with increased reactive oxygen species (ROS), regular training improves hepatic antioxidant status. Also, oxytocin (Oxy), besides its classical functions, it exhibits a potent antistress, anti-inflammatory, and antioxidant effects. This study was designed to evaluate the hepatic functional and structural changes induced by hepatic IR injury in rats and to probe the effect and potential mechanism of moderate intensity exercise training and/or Oxy, in comparison to a nitric oxide donor, l-arginine, against liver IR-induced damage.

Results
Compared to the sham-operated control group, the hepatic IR group displayed a significant increase in serum levels of ALT and AST, plasma levels of MDA and TNF-α, and significant decrease in plasma TAC and nitrite levels together with the worsening of liver histological picture. L-Arg, Oxy, moderate intensity exercise, and the combination of both Oxy and moderate intensity exercises ameliorated these deleterious effects that were evident by the significant decrease in serum levels of ALT and AST, significant elevation in TAC and nitrite, and significant decline in lipid peroxidation (MDA) and TNF-α, besides regression of histopathological score regarding hepatocyte necrosis, vacuolization, and nuclear pyknosis. Both the moderate intensity exercise-trained group and Oxy-treated group showed a significant decline in TNF-α and nitrite levels as compared to l-Arg-treated group. The Oxy-treated group showed statistical insignificant changes in serum levels of ALT, AST, and plasma levels of nitrite, MDA, TAC, and TNF-α as compared to moderate intensity exercise-trained group.

Conclusion
The combination of both moderate intensity exercise and Oxy displayed more pronounced hepatoprotection on comparison with l-Arg which could be attributed to their more prominent antioxidant and anti-inflammatory effects but not due to their NO-enhancing effect.
Serum allergen-specific IGE to common aeroallergens among allergic rhinitis patients in Egypt
Authors: Elkady Hossam Moustafa , Atef Ahmed 
Published: May 2021

Abstract
Background
Allergic rhinitis is the most prevalent allergic disease, and the prevalence and sensitization patterns differ among countries. Identifying the most common inhalant allergen in each region plays a key role in the diagnosis and management of allergic rhinitis. There are no data available about the most prevalent aeroallergen among allergic rhinitis patients in Egypt. The aim of this study is to evaluate the prevalence of positive serum allergen-specific IGE to common inhalant allergens among allergic rhinitis patients in Egypt. A cross-sectional study was conducted on 354 allergic rhinitis patients, serum allergen-specific IGE was measured by using the Immuno CAP system to 16 common regional aeroallergens including (pollens, mite, molds, animal dander, and cockroach).

Results
The overall rate of sensitization to any allergen was 74.6%. Dermatophagoides pteronyssinus, birch pollens, and Dermatophagoides farina were the most prevalent allergens (29.7%, 23.7%, and 18.6%), respectively. Cladosporuim molds were the least prevalent individual allergens (1.7%).

Conclusion
Our data suggest that Dermatophagoides pteronyssinus and birch pollens were the predominant allergen sources among allergic rhinitis patient in Egypt.
Presidential Rhetoric on Foreign Crises: George W. Bush on Georgia and Barack Obama on Ukraine
Authors: Rzepecka Marta 
Published: May 2021

Presidential Rhetoric on Foreign Crises: George W. Bush on Georgia and Barack Obama on Ukraine
This article offers a critique of the rhetorical responses of President George W. Bush to the 2008 Russia-Georgia conflict and of President Barack Obama to the 2014 Russia-Ukraine conflict. Its central objective is to identify parallels and differences between the situations calling for presidential rhetoric on the crises in Georgia and Ukraine and determine how the president’s reactions to the conflicts were similar or different, judging the responses against Theodore Otto Windt, Jr.’s analytical framework for foreign crisis rhetoric.