bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short- and long-term haemodynamic consequences of transcatheter closure of atrial septal defect and patent foramen ovale
Authors: Jin X. , Hummel Y. M. , Tay W. T. , Nauta J. F. , Bamadhaj N. S. S. , van Melle J. P. , Lam C. S. P. , Voors A. A. , Hoendermis E. S. 
Published: February 2021

Abstract
Background
Transcatheter atrial septal defect (ASD) and patent foramen ovale (PFO) closure might have opposite short- and long-term haemodynamic consequences compared with restricted interatrial shunt creation, which recently emerged as a potential treatment modality for patients with heart failure with preserved ejection fraction (HFpEF). Given the opposing approaches of ASD and PFO closure versus shunt creation, we investigated the early and sustained cardiac structural and functional changes following transcatheter ASD or PFO closure.

Methods
In this retrospective study, adult secundum-type ASD and PFO patients with complete echocardiography examinations at baseline and at 1‑day and 1‑year follow-up who also underwent transcatheter closure between 2013 and 2017 at the University Medical Centre Groningen, the Netherlands were included.

Results
Thirty-nine patients (mean age 48 ± standard deviation 16 years, 61.5% women) were included. Transcatheter ASD/PFO closure resulted in an early and persistent decrease in right ventricular systolic and diastolic function. Additionally, transcatheter ASD/PFO closure resulted in an early and sustained favourable response of left ventricular (LV) systolic function, but also in deterioration of LV diastolic function with an increase in LV filling pressure (LVFP), as assessed by echocardiography. Age (β = 0.31, p = 0.009) and atrial fibrillation (AF; β = 0.24, p = 0.03) were associated with a sustained increase in LVFP after transcatheter ASD/PFO closure estimated by mean E/e’ ratio (i.e. ratio of mitral peak velocity of early filling to diastolic mitral annular velocity). In subgroup analysis, this was similar for ASD and PFO closure.

Conclusion
Older patients and patients with AF were predisposed to sustained increases in left-sided filling pressures resembling HFpEF following ASD or PFO closure. Consequently, these findings support the current concept that creating a restricted interatrial shunt might be beneficial, particularly in elderly HFpEF patients with AF.
The Mandalovoo–Gurvansayhan terranes in the southern Gobi of Mongolia: new insights from the Bayankhoshuu Ruins section
Authors: Munkhjargal A. , Königshof P. , Waters J. A. , Carmichael S. K. , Gonchigdorj S. , Thassanapak H. , Udchachon M. , Davaanyam Sh. 
Published: February 2021

AbstractThe Bayankhoshuu Ruins section in southern Mongolia is characterized by strongly thrusted and folded sequences. Overall, three sections ranging from Ordovician to Carboniferous rocks were studied. Facies analysis combined with stratigraphic data provide improved lithostratigraphic descriptions of Palaeozoic successions in the Mushgai region. The overall marine sedimentary sequence is punctuated by volcanic rocks–basaltic lava of Silurian and Middle Devonian age and volcaniclastic bentonite and tuff in the Middle to Late Devonian and Mississippian suggesting an island arc setting. The Minjin Member of the Botuulkhudag Formation (Middle Devonian to Late Devonian) is primarily composed of thick basaltic and subaerial volcanic rocks with minor silicified siltstone and chert inclusions. Thicker successions of limestone occur in the Ordovician/Silurian, Early Devonian, and the Mississippian. The macrofauna is scarce, except distinct limestone horizons where different fossil groups were recognized. Microfossils, such as radiolarians and conodonts, are scarce and generally poorly preserved. However, based on the re-study of collections from earlier publications and new conodont data, a more detailed biostratigraphic record of the Khoyormod, Botuulkhudag, and Arynshand formations of the Bayankhoshuu Ruins section can be developed. For instance, the Arynshand Formation likely ranges from the late Bispathodus ultimus conodont biozone to the Scaliognathus anchoralis–Doliognathus latus conodont biozone. A tectonic breccia occurs in the early Mississippian and is overlain by a red shale of remarkable thickness at the top of this formation which points to subaerial exposure in the early Mississippian (near the Tournaisian/Visean transition). Due to strong tectonic overprint and/or facies, some unconformities/hiatuses occur. Most strata are intensively folded and faulted, ranging from centimeter to meter scale. Overall, deposition likely occurred on either the Mandalovoo or Gurvansayhan Terrane.
Comparison of Atmospheric Vertical Motion over China in ERA-Interim, JRA-55, and NCEP/NCAR Reanalysis Datasets
Authors: Xu Jiayu , Tian Rongxiang , Feng Song 
Published: February 2021

AbstractVertical motion is an important feature of the atmosphere, being closely linked to clouds and precipitation. Here, we present a comparison of the vertical velocity of air over China, with particular focus on the Tibetan Plateau, during the period 1981–2010 using three reanalysis datasets: ERA-Interim, JRA-55 and NCEP/NCAR. Analysis methods including empirical orthogonal functions analysis and correlation analysis were used to examine consistency between the datasets and their suitability in research and application in China. Our results show that the vertical velocity fields from ERA-Interim and JRA-55 are more consistent than they are with those from NCEP/NCAR. The atmospheric vertical velocity fields from NCEP/NCAR lack details compared with those obtained from ERA-Interim and JRA-55, and part of values for the upper troposphere over the ocean south of 15°N are contrary to the other datasets and the climatic reality. Therefore, use of ERA-Interim or JRA-55 may be preferable over NCEP/NCAR. The intensity of atmospheric vertical motion in the lower troposphere in JRA-55 is significantly higher than in ERA-Interim and NCEP/NCAR. In summer, the JRA-55 data are closest to the observed wind fields and the data stability best for the Tibetan Plateau region. Our results provide guidance for better application of reanalysis data and more accurate climate prediction for this region.
Re-examining utopia in contemporary consumption: conceptualization and implications for marketing
Authors: Atanasova Aleksandrina 
Published: February 2021

AbstractThis paper introduces liquid consumer utopias, defined as market-mediated expressions of individuals’ desires to re-imagine and re-construct reality, and to re-frame the present. This conceptual lens illuminates previously untheorized consumption phenomena, which are socially constructed, and often critical, efforts to enact an alternative way of being in an increasingly uncertain and unpredictable world. Three key characteristics of liquid utopias are outlined—immediacy, transience and hyper-individualization––each pointing to liquid consumer utopias’ function to facilitate present-oriented and short-lived re-imaginings of reality. Co-existing alongside the solid and collective utopian consumption of interest to prior research, these emergent forms of liquid consumer utopias articulate a re-imagining of the present (rather than the future), have an emphasis on individual (rather than communal) experiences of betterment, and an orientation toward temporary re-framings of the experienced reality (rather than a pursuit of permanence and long-lasting change). Implications are discussed for retailing, experiential consumption, and consumer self-optimization.
Statistical analyses of groundwater chemistry in the Qingdong coalmine, northern Anhui province, China: implications for water–rock interaction and water source identification
Authors: Chen Kai , Sun Linhua , Xu Jiying 
Published: February 2021

AbstractHydrochemistry of groundwater is important in coal mines because it can be used for understanding water–rock interaction and inrush water source identification. In this study, major ion concentrations of groundwater samples from the loose layer aquifer (LA), coal-bearing aquifer (CA) and Taiyuan Formation limestone aquifer (TA) in the Qingdong coal mine, northern Anhui province, China, have been analyzed by a series of statistical methods for identifying the source of chemical constituents in groundwater and the source of inrush water. The results indicate that the mean concentration of the major ions in the LA were ordered as follows: HCO3− > SO42− > Na+ + K+  > Cl− > Ca2+ > Mg2+ > CO32−, whereas average values of the CA in decreasing order are SO42−, Na+ + K+, HCO3−, Cl−, Ca2+, Mg2+ and CO32−, and the major ion concentrations of the TA have the following order: SO42− > Na+ + K+ > Ca2+  > HCO3− > Cl− > Mg2+ > CO32−, and most of the samples are Na-SO4 and Ca-SO4 types. TDS content in water increases with aquifer depth, whereas the pH values ranged from 7.1 to 8.9, indicating a weak alkaline environment. Two sources (weathering of silicate minerals and dissolution of evaporate minerals) have been identified by principal component analysis responsible for the chemical variations of the groundwater, and their contribution ratios have been quantified by Unmix model. Moreover, based on the Q-mode cluster and discriminant analyses, the samples with known sources have been identified correctly to be 95.7% and 97.6%, respectively, and the samples with unknown sources have been determined with high probability (78–100%).
Sensorimotor Representation Learning for an “Active Self” in Robots: A Model Survey
Authors: Nguyen Phuong D. H. , Georgie Yasmin Kim , Kayhan Ezgi , Eppe Manfred , Hafner Verena Vanessa , Wermter Stefan 
Published: February 2021

AbstractSafe human-robot interactions require robots to be able to learn how to behave appropriately in spaces populated by people and thus to cope with the challenges posed by our dynamic and unstructured environment, rather than being provided a rigid set of rules for operations. In humans, these capabilities are thought to be related to our ability to perceive our body in space, sensing the location of our limbs during movement, being aware of other objects and agents, and controlling our body parts to interact with them intentionally. Toward the next generation of robots with bio-inspired capacities, in this paper, we first review the developmental processes of underlying mechanisms of these abilities: The sensory representations of body schema, peripersonal space, and the active self in humans. Second, we provide a survey of robotics models of these sensory representations and robotics models of the self; and we compare these models with the human counterparts. Finally, we analyze what is missing from these robotics models and propose a theoretical computational framework, which aims to allow the emergence of the sense of self in artificial agents by developing sensory representations through self-exploration.
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling
Authors: Yuan Juanjuan , Cai Ting , Zheng Xiaojun , Ren Yangzi , Qi Jingwen , Lu Xiaofei , Chen Huihui , Lin Huizhen , Chen Zijie , Liu Mengnan , He Shangwen , Chen Qijun , Feng Siyang , Wu Yingjun , Zhang Zhenhai , Ding Yanqing , Yang Wei 
Published: February 2021

AbstractMetabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which has been previously identified as a transporter for cholesterol, plays a pivotal role in regulating CD8+ T cell antitumor activity. Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion, we also found a non-canonical function of LDLR in CD8+ T cells: LDLR interacts with the T-cell receptor (TCR) complex and regulates TCR recycling and signaling, thus facilitating the effector function of cytotoxic T-lymphocytes (CTLs). Furthermore, we found that the tumor microenvironment (TME) downregulates CD8+ T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs. Moreover, genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+ T cells by alleviating the suppressive effect on CD8+ T cells and consequently inhibit tumor progression. While previously established as a hypercholesterolemia target, this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well.
Case report. Emfysemateuze pyelonefritis bij kinderen
Authors: Jacobs Rens A. L. , Callewaert Piet R. H. 
Published: February 2021

SamenvattingIn dit case report beschrijven wij het diagnose- en behandeltraject van een 12-jarige patiënt met een emfysemateuze pyelonefritis (EPN) ten gevolge van een pyelo-ureterale junctie stenose. Een EPN bij kinderen is uiterst zeldzaam. De exacte pathogenese van EPN is onbekend, maar het voorkomen lijkt geassocieerd te zijn met obstructie van de urinewegen, stenen of een gestoorde afweer. In tegenstelling tot bij de volwassen populatie met EPN lijkt diabetes mellitus bij kinderen geen risicofactor. Het klinisch beeld van EPN kan variëren van symptomen die passen bij een klassieke pyelonefritis tot een ernstige septische shock. Computertomografisch onderzoek vormt de beste diagnostische modaliteit. Behandeling bestaat uit spoedige resuscitatie van de septische patiënt in combinatie met drainage van de nier in geval van obstructie. De klinische uitkomst bij kinderen is over het algemeen goed.
Converted Structures: Exploring Material Expressions of the Sacred and Secular
Authors: Hartson Taylor E. 
Published: February 2021

Background Increasingly across the Western world, traditional religious buildings are being converted for secular use, like housing, restaurants, or performance halls. At the same time, congregations are appearing in formerly secular spaces, adapting old shopping malls, storefronts, and movie theaters for their spaces of worship. Purpose This study employs a novel methodology to identify where these hybrid buildings are located and to explore what these buildings might mean in the context of the American religious landscape. Methods Using a database of addresses identified as potential converted structure candidates, I conduct one of the first known attempts to systematically identify these building conversions. I employed the Google Street View tool to locate these buildings in six mid-sized cities in the United States. Once these buildings had been located, I collected visual data of the exteriors using Google Street View and identified the presence of sacred and secular formal and functional elements present in the buildings. Results Based on the formal and functional elements identified in each conversion, I expanded Hackworth and Gullikson's (2013) typology for converted structures to include eight potential categories of conversion, five of which are represented by cases from my sample. I located 175 secular-to-sacred building conversions and 12 sacred-to-secular building conversions. Of the 175 secular-to-sacred building conversions, 89 buildings fell into the “secular form, mixed function” category, while 86 fell into the “secular form, sacred function” category. Of the 12 sacred-to-secular building conversions, 10 fell into the “sacred form, secular function” category, while 2 fell into the “mixed form, secular function” category. Additionally, while not an initial focus of this study, my sample included 2 building conversions that fell into the “sacred form, sacred function” category, revealing the third direction of building conversion: sacred-to-sacred. Conclusions and Implications While these findings are limited in their scope, I argue that continued exploration of these structures by expansion of this methodology and the addition of ethnographic research foreground the interaction between material objects and human relationships in the construction, deconstruction, and preservation of sacred and secular boundaries.
Variations on a Conjecture of C. C. Yang Concerning Periodicity
Authors: Liu Xinling , Korhonen Risto , Liu Kai 
Published: February 2021

AbstractThe generalized Yang’s Conjecture states that if, given an entire function f(z) and positive integers n and k, $$f(z)^nf^{(k)}(z)$$

f

(
z
)

n

f

(
k
)

(
z
)

is a periodic function, then f(z) is also a periodic function. In this paper, it is shown that the generalized Yang’s conjecture is true for meromorphic functions in the case $$k=1$$

k
=
1

. When $$k\ge 2$$

k
≥
2

the conjecture is shown to be true under certain conditions even if n is allowed to have negative integer values.
Determining the potential link of self-compassion with eating pathology and body image among women: a longitudinal mediational study
Authors: Turk Fidan , Kellett Stephen , Waller Glenn 
Published: February 2021

Abstract
Purpose
This longitudinal study aims to determine what factors mediate the previously established link between self-compassion and eating pathology/body image concerns, over a 6-month period.

Methods
A community sample of 274 adult women (M = 29.50 years) completed standardised validated measures of self-compassion (Self-Compassion Scale), rumination (Ruminative Thought Style Questionnaire), shame (Other as Shamer Scale), perfectionism (Short Form of the Revised Almost Perfect Scale), self-criticism (Levels of Self-Criticism Scale), eating pathology (Eating Disorder Examination Questionnaire) and body image (Body Shape Questionnaire). They reported levels of: self-compassion at Time 1, potential mediators (rumination, shame, self-criticism, perfectionism) at 3 months; and eating pathology and body dissatisfaction a further 3 months later. Missing data were handled using multiple imputation. Stepwise multiple regression showed that shame was the most consistent mediator.

Results
Shame acted as a full mediator of the self-compassion-eating/body image relationship {respectively, [B = .04, SE = .01, t(268) = 3.93, p < .001], [B = .33, SE = .15, t(268) = 2.25, p < .05]}. Discrepancy perfectionism also played a mediating role in the link between self-compassion and body image dissatisfaction [B = .59, SE = .28, t(268) = 2.10, p < .05].

Conclusion
These results support the hypothesis that self-compassion is relevant to eating pathology and body image disturbance, and demonstrate that shame is an important mechanism in that relationship. This pattern suggests that interventions that reduce shame should be considered when addressing issues relating to self-compassion and its links to eating disorders.

Level of evidence
Level IV, multiple time series without intervention.
The patterns and burden of multimorbidity in geriatric patients with prolonged use of addictive medications
Authors: Cheng Socheat , Siddiqui Tahreem Ghazal , Gossop Michael , Wyller Torgeir Bruun , Kristoffersen Espen Saxhaug , Lundqvist Christofer 
Published: February 2021

Abstract
Background
Multimorbidity and prolonged use of addictive medications are prevalent among older patients, and known to increase the risk of adverse drug events. Yet, the relationship between these two entities has remained understudied.

Aims
This study explored the association between multimorbidity burden and prolonged use of addictive medications in geriatric patients, adjusted for clinically important covariates. Furthermore, we identified comorbidity patterns in prolonged users.

Methods
We conducted a cross-sectional study on a consecutive sample of 246 patients, aged 65–90 years, admitted to a large public university hospital in Norway. We defined prolonged use of addictive medications as using benzodiazepines, opioids and/or z-hypnotics beyond the duration recommended by clinical guidelines (≥ 4 weeks). Multimorbidity was assessed with the Cumulative Illness Rating Scale for Geriatrics (CIRS-G), based on diagnoses made by independent physicians.

Results
Compared to non-prolonged use, prolonged use was significantly more common among patients who had psychiatric (19/27, 70%), liver (19/22, 86%), upper gastrointestinal tract (21/32, 66%), musculoskeletal (52/96, 54%), or nervous system disorders (46/92, 50%). Patients with prolonged use had a higher multimorbidity burden than those without such use (CIRS-G score, mean = 7.7, SD = 2.7 versus mean = 4.6, SD = 2.2, p < 0.001). Multivariable logistic regression indicated a significant association between multimorbidity burden and prolonged addictive medication use (OR = 1.72, 95% CI 1.42–2.08). Predictive margins postestimation showed a systematic increase in the predicted CIRS-G scores when the number of addictive drug used increases.

Conclusions
Multimorbidity is strongly associated with prolonged use of addictive medications. Multiple substance use may aggravate disease burden of older patients.
Entwicklung und empirische Validierung eines kontextorientierten Skalenmodells zur Erfassung des Interesses von Schüler*innen am Klimawandel
Authors: Thieroff Bernhard , Schubert Jan Christoph , Gölitz Dietmar 
Published: February 2021

ZusammenfassungDer Klimawandel stellt eine der wesentlichen Herausforderungen des 21. Jahrhunderts dar und gilt durch seine Struktur als hochrelevantes Thema im Geographieunterricht. Gleichzeitig stellt Interesse eine der zentralen themenspezifischen Voraussetzungen für fachliches Lernen dar. Bezogen auf den Klimawandel ist dieses bisher allerdings nur in Ansätzen erforscht. Die vorliegende Studie entwickelte daher auf Basis themenspezifischer sowie geographiedidaktischer Vorüberlegungen einen Fragebogen zur Erfassung kontextbezogenen Schüler*inneninteresses am Klimawandel. Im Zuge einer Faktorenanalyse ergaben sich fünf eindeutige Faktoren mit jeweils angemessenen bis hohen Reliabilitätswerten. Auf Ebene der unterrichtlichen Kontexte zeigten sich die lebensweltlich orientierten und individuell geprägten Kontexte Handlung sowie räumliche Nähe als besonders gewichtige Determinanten des Schüler*inneninteresses. Weiterhin ergab sich der Kontext Messung/Methodik. Mit Blick auf die fachlich-inhaltliche Struktur des Themas konnten die Faktoren globale Ursachen sowie Folgen als interesseleitend identifiziert werden. Es zeigte sich, dass das Interesse am Klimawandel vor allem durch die Lebenswelt sowie den Alltag der Schüler*innen betreffende Kontexte (z. B. den Nah‑/Heimatraum) determiniert wird. Die inhaltlichen Facetten des Themas spielen – zumindest soweit diese Kontexte berührt werden – eine nachgeordnete Rolle. Somit liegt ein hochreliables Verfahren zur Erfassung des Schüler*inneninteresses am Klimawandel gegen Ende der Sekundarstufe I vor, das eine Ausdifferenzierung des derzeitigen Forschungsstandes sowie eine interessenbezogene Wirksamkeitsprüfung unterrichtlicher Interventionen ermöglicht.
Vescicole extracellulari e metabolismo osseo: ruolo e possibili implicazioni cliniche
Authors: Bianciardi Simone , Merlotti Daniela , Materozzi Maria 
Published: February 2021

SommarioLe vescicole extracellulari (EV) sono secrete da vari tipi cellulari e veicolano cargo specifici destinati alle cellule target, mediando così effetti paracrini in meccanismi fisiologici e patologici. Negli ultimi anni lo studio delle EV si è affermato in moltissimi ambiti, compreso il mondo del metabolismo osseo. In questa rassegna riportiamo i più recenti e promettenti studi sul ruolo biologico delle EV nel tessuto osseo e il loro potenziale utilizzo in strategie terapeutiche.