bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nusselt Number and Friction Factor Correlations Development for Arc-Shape Apex Upstream Artificial Roughness in Solar Air Heater
Authors: Sahu Mukesh Kumar , Kharub Manjeet , Matheswaran Mahalingam Murugesan 
Published: December 2021

Abstract
In the present work an outdoor experimental investigation for solar air heater with arc-shaped apex-upstream flow by the use of circular cross section wires as roughness elements has been carried out. The roughness-element have been expressed in non-dimensionalizing geometric parameters as relative roughness-pitch (P/e), relative roughness-height (e/D) and flow attack-angle (α/60), and the range of these parameters varies from 8 to 15, 0.0454, and 0.75 to 1.25, respectively. For evaluation of performance of the roughened SAH, a novel parameter has been proposed and introduced in the present investigation which is Thermo-Hydraulic Improvement Parameter (THIP). With the use of present roughness geometry, considerably Nusselt number enhancement ratio (NNER) and friction factor enhancement ratio (FFER) have been observed. The maximum NNER and FFER values obtained experimentally is about 2.83 and 1.79 times, respectively. While, the maximum THIP has been obtained 157.49% higher than the smooth SAH. Using the experimental results correlations for the output parameters (Nusselt number and friction factor) as a function of input parameters (flow and roughness) have been developed.
Impact of Waste Heat Recovery of Chimney Using U-Shaped Pulsating Heat Pipe to Generate Hot Water- Experimental and Environmental Analysis
Authors: Shoeibi Shahin , Kargarsharifabad Hadi , Rashidi Mohammad Mehdi 
Published: December 2021

Abstract
Many studies have been done on the Pulsating heat pipes (PHP) using energy applications system. In this study a heat exchanger PHP is analyzed. A heat pipe prototype is manufactured for waste heat recovery. The present study experimentally investigated the effect of pulsating heat pipe on the waste heat recovery of the chimney and produce hot water for household consumption. The evaporator is placed in a smoke exhaust duct and the condenser is located in a water chamber in which the smoke heat is transferred through. The results are presented for different heat pipe angles to the horizon from 0 to 90. The PHP is filled 60% by distilled water as operating fluid. The highest hot water temperature in outlet of reservoir was about to 58 oC. Also, The CO2 mitigation and CPH of the waste heat recovery system was equal to 84.82 tons and 0.1$/m3. Moreover, the efficiency is changing from 19% for a horizontal PHP to 54% for a vertical one.
Study On Spectral Characters-Chlorophyll Inversion Model of Sabina Vulgaris in Mu Us Sandy Land
Authors: Wang Ning , Yang Guang , Han Xueying , Jia Guangpu , Liu Feng , Liu Xin , Chen Haoyu , Zhang Tianqi , Guo Xinyu 
Published: December 2021

Abstract
Sabina vulgaris is a group tree species in Mu Us Sandy Land. Understanding the growth status of Sabina vulgaris has guiding value for vegetation change monitoring. Chlorophyll is an important indicator to characterize the growth status of plants, and its content changes are important for analyzing the physiological growth status of plants and guiding the precise planting of plants. In this paper, the spectral reflectance and chlorophyll content of Sabina vulgaris were measured by SVC HR-1024 portable ground feature spectrometer and SPAD502 chlorophyll instrument, and the relationship between ground feature spectral characteristics and chlorophyll content of Sabina vulgaris was studied. The results show that there is a correlation between the vegetation index and chlorophyll, the effect of NDVI is the best, the bands with the highest correlation are the combined bands of 470nm-500nm, 610nm-680nm, and 740nm-840nm, and the wavelengths with the highest correlation are (660,790); Vegetation index, red-edge parameters, and chlorophyll have a certain correlation. The fitting effect of the model established by vegetation index is better than that established by red-edge parameters, and the highest R2 is 0.97; Among the three modeling methods, the model fitting effect of partial least squares is the best, R2 is > 0.91, and the disadvantage is that the processing process is complex; The processing method of the univariate linear regression model is the simplest, but the disadvantage is that the accuracy of the model is unstable, R2 is between 0.1-0.9, so the multivariate linear regression model is the most suitable of the three methods(R2>0.8).
Longitudinal Prediction of Motor Dysfunction After Stroke: A Disconnectome Study.
Authors: Dulyan Lilit , Talozzi Lia , Pacella Valentina , Corbetta Maurizio , Forkel Stephanie J , de Schotten Michel Thiebaut 
Published: December 2021

Abstract
Motricity is the most commonly affected ability after a stroke. While many clinical studies attempt to predict motor symptoms at different chronic time points after a stroke, longitudinal acute-to-chronic studies remain scarce. Taking advantage of recent advances in mapping brain disconnections, we predict motor outcomes in 62 patients assessed longitudinally two weeks, three months, and one year after their stroke. Results indicate that brain disconnection patterns accurately predict motor impairments. However, disconnection patterns leading to impairment differ between the three time points and between left and right motor impairments. These results were cross-validated using resampling techniques. In sum, we demonstrated that while some neuroplasticity mechanisms exist changing the structure-function relationship, disconnection patterns prevail when predicting motor impairment at different time points after stroke.
A Critical Analysis of Effect of Projected Temperature and Rainfall for Differential Sowing of Maize Cultivars Under RCP4.5 and RCP6.0 Scenarios for Punjab
Authors: Kothiyal Shivani , Kaur Prabhjyot , Kaur Jatinder 
Published: December 2021

Abstract
A simulation study was conducted for two cultivars of maize (PMH1 and PMH2) in four agroclimatic zones of Punjab state of India where climate change depicts a consistent rise in temperature and increased variability in amount and distribution of rainfall. The yield assessment was performed for four agroclimatic zones of Punjab comprising of seven locations because variability in temperature rise and rainfall existed from location to location. Corrected ensemble model weather data (temperature and rainfall) for RCP4.5 and RCP6.0 was used as an input in the calibrated and validated CERES-Maize model and yield was simulated for a period of 70 years. The simulated yield for near as well as far-future was statistically assessed to understand the yield trend in Punjab under current dates of sowing and the results indicated a strong negative correlation between the yield and the weather parameters under the two scenarios at the considered four agroclimatic zones of Punjab. An increase in maximum and minimum temperature was observed ranging 0-4°C and 3-8°C, respectively at all the agroclimatic zones except Faridkot (zone V) where the increase in minimum temperature was observed by 0-3°C during the crop growth season while the rainfall variability ranged from 200-800mm under both the scenarios. At agroclimatic zone II and zone III similar results were obtained with higher yields at later dates of sowing and the rainfall at agroclimatic zone III was higher under RCP6.0 (300-600mm) while the yields for agroclimatic zone IV and V (Abohar) with rainfall variation of 270-450mm and 200-400mm, respectively showed no yield increment. Maize at Faridkot performed well with higher yields at early sowing dates. Among the two cultivars PMH1 showed more high yield years than PMH2 for most of the years. The yield under differential sowing dates showed the first fortnight of June and end June to be the best sowing dates for most of the locations as the yield for these dates were higher for most of the years. Thus, the study can be further applied to decide the future sowing window of maize for the agricultural state like Punjab.
Real-World Data of Off-Label Drug Use in Patients with Actionable Genomic Alterations on Next-Generation Sequencing
Authors: Souza Gabriel Roman , Abdalla Ahmed , Arora Sukeshi Patel , Mahadevan Daruka 
Published: December 2021

Abstract
We analyzed the outcomes of patients in our institution treated with off-label drugs targeting actionable genomic alteration based on next-generation sequencing when clinical trials were not available. Our study endpoint was objective tumor response or stable disease at 16 weeks or later after treatment initiation. Sixteen patients were included in this study, 8 were treated with immune checkpoint inhibitors targeting PD-L1 or TP53 mutations and 8 with other drugs. Tumors were analyzed based on PD-L1 expression, TP53 mutation, MSI, TMB, MMR status, and other targetable alterations. Of the 16 patients in the intention-to-treat group, no patients had an objective response after 16 weeks. Eleven patients met the primary study endpoint with stable disease, 8 in the immune checkpoint inhibitors group and 3 in the non-immune checkpoint inhibitors group. Using the log-rank test, the p-value for the difference between groups was 0.008. In this study with off-label drugs, immune checkpoint inhibitors targeting TP53 mutations or PD-L1 expression were superior to the other drugs. This suggests the possibility of off-label use of anti-cancer drugs based on next-generation sequencing to be beneficial for advanced cancer patients without other therapeutic options.
Depressive-Like Behavior Induced by Long-Term Ouabain Administration Accompanied Alteration in Neuroinflammation Parameters in Rats
Authors: Valvassori Samira S. , Aguiar-Geraldo Jorge M. , Possamai-Della Taise , da-Rosa Dayane D. , Menegas Samira , Dal-Pont Gustavo C. , Cararo José H. , Quevedo João 
Published: December 2021

Abstract
Objective: The present study aims to investigate the effects of Lithium (Li) on manic- and depressive-like behaviors and inflammatory parameters in rats submitted to the bipolar disorder (BD) model induced by ouabain (OUA). Material and methods: Adult male rats received a single intracerebroventricular (ICV) injection of OUA or artificial cerebrospinal fluid (aCSF). On the fourth day after the ICV injection, the rats received intraperitoneal injections of saline (NaCl 0.9%) or Li (47.5 mg/kg), two times a day, for 14 days. On the seventh day after OUA injection, the locomotor activity was assessed (open field test), and on the fourteenth day, locomotion was evaluated again, which was followed by the forced swimming test to evaluate depressive-like behavior. After euthanasia, inflammatory parameters were evaluated in the frontal cortex and hippocampus. Results: After seven days of OUA administration, the animals showed a hyperactive behavior that was reversed by treatment with Li. After 14 days of ICV injections, rats exhibited a depressive behavior. Regarding the inflammatory parameters, measured after 14 days of the ICV infusions, OAU induced an increase in the levels of interleukin (IL)-1β, IL-6, tumor necrosis factor α, and cytokine-induced neutrophil chemoattractant-1. In contrast, Li treatment decreased these parameters. Conclusion: The animal model of BD induced by an OUA is able to induce neuroinflammation, which supports its construct validity for the BD research.
Rainfall Trend And Seasonality Estimation For Marathwada Region
Authors: Bana Himanshu , Garg R. D 
Published: December 2021

Abstract
The present research work conducts a seasonality and trend analysis of rainfall over the 8 districts of the Marathwada region India. The study is carried out for the last 39 years ranging from 1980 to 2018. The rainfall data analysed pertains to pre-monsoon season, monsoon season (Kharif), and annual. The trend has been estimated using Sen’s slope estimation process along with Mann-Kendal test. It was observed that the all the Eight districts of the region show a negative trend in the annual rainfall received. Nanded district showed the largest negative trend in the annual rainfall. Out of eight districts seven districts of the region show a decline in rainfall during the monsoon season. The district of Nanded showed largest decline in the rainfall received during monsoon season. The present research work concludes with discussion on possible causes of such estimated trends.
Use of Oral Glucose Tolerance Testing and HbA1c At 6-14 Gestational Weeks to Predict Gestational Diabetes Mellitus In High-Risk Women
Authors: Peng Xiaoxiao , Liu Mingyi , Gang Jun , Wang Ying , Ma XiuHua 
Published: December 2021

Abstract
Objective:To study the prediction of gestational diabetes mellitus (GDM) in high-risk pregnant women by testing the 1-hour (1hPG) and 2-hour plasma glucose (2hPG) after an oral glucose tolerance test and the glycated hemoglobin (HbA1c) in early pregnancy (6-14 weeks).Methodology:We recruited 1311 pregnant women at high risk for diabetes from the Obstetrics Clinic of Daxing District People's Hospital between June 2017 and December 2019. Fasting blood glucose (FPG) and HbA1c were tested and a 75 g oral glucose tolerance test (OGTT) with 1-hour blood glucose (1hPG) and 2-hour blood glucose (2hPG) was performed during the first trimester of pregnancy. The women were seen at 24-28 weeks to follow-up for GDM. We calculated the receiver operating characteristic (ROC) and the area under the ROC curve (AUC) to determine the predictive values for early pregnancy FPG, 1hPG, 2hPG, and HbA1c for GDM in high-risk pregnant women.Results:The prevalence of pregestational diabetes mellitus among pregnant women at high risk of diabetes was 5.6%, and GDM was 24.7%. The AUCs for the predictive value of FPG, 1hPG, 2hPG, and HbA1c in high-risk pregnant women were 0.64, 0.76, 0.71, and 0.67, respectively. The AUC for 1hPG prediction of GDM in high-risk pregnant women is greater than FPG, 2hPG, and HbA1c. All differences were statistically significant.Conclusion:FPG, 1hPG, 2hPG, and HbA1c measured in the first trimester pregnancy of high-risk women are significant predictors of GDM. 1hPG was the most significant predictive value for GDM in high-risk pregnant women.
Receiving Screened Donor Human Milk for Their Infant Supports Parental Wellbeing: a Mixed-methods Study
Authors: Brown Amy , Shenker Natalie 
Published: December 2021

Abstract
Background: Donor human milk (DHM) protects the health and development of premature infants but there has been little examination of the broader impact of an infant receiving it upon parental mental health. Breastfeeding and mental health are closely tied with women who experience breastfeeding difficulties or are unable to meet their own breastfeeding goals often experiencing feelings of guilt, sadness and anger, alongside an increased risk of postnatal depression. The aim of the current study was to explore how experience of receiving DHM for their baby affected the wellbeing of parents.Methods: UK parents of infants aged 0 – 12 months who had received screened DHM from a milk bank (typically on the neonatal unit or in some cases in the community) completed an online questionnaire exploring their experiences. The questionnaire included Likert scale items examining perceived impact upon infant health, own wellbeing and family functioning alongside open-ended questions exploring perceptions of how receiving DHM affected wellbeing.Results: Almost all of the 107 participants (women=102) agreed that receiving DHM had a positive impact upon infant health and development, their own mental and physical health, and their family’s wellbeing. Parents felt relieved that their infant was receiving DHM for health reasons but also due to the experience of being listened to, supported and having their infant feeding decisions facilitated. Receiving DHM helped mothers to process some of their emotions at not being able to breastfeed, in part because knowing their baby was being fed gave them the space to focus on recovery and bonding with their baby. Some parents did experience challenges, feeling guilty at receiving DHM, insecure that another woman was able to feed their baby when they could not, with some negative reactions from family. Although the impact of receiving DHM upon breastfeeding was not measured, some women who were working to build their own milk supply noted that it helped motivate them to continue.Conclusions: DHM may play an important role not only in protecting infant health and development but in supporting the mental health and wellbeing of mothers for whom their infant receiving human milk is important.
Defining the Impact of Adjuvant Treatment on the Prognosis of Patients with Inoperable Glioblastoma Undergoing Biopsy-only: Does the Survival Benefit Outweigh the Treatment Effort?
Authors: Löber-Handwerker Ronja , Döring Katja , Bock Christoph , Rohde Veit , Malinova Vesna 
Published: December 2021

Abstract
Purpose: Patients with inoperable glioblastoma (GBM) usually experience worse prognosis compared to those in whom gross total resection (GTR) is achievable. Considering the treatment duration and its side effects identification of patients with survival benefit from treatment is essential to guarantee the best achievable quality of life. The aim of this study was to evaluate the survival benefit from radio-chemotherapy and to identify clinical, molecular, and imaging parameters associated with better outcome in patients with biopsied GBMs. Methods: Consecutive patients with inoperable GBM, who underwent tumor biopsy at our department from 2005 to 2019 were retrospectively analyzed. All patients had histologically confirmed GBM and were followed up until death. The overall survival (OS) was calculated from date of diagnosis to date of death. Clinical, radiological and molecular predictors of OS were evaluated. Results: A total of 95 patients with biopsied primary GBM were enrolled in the study. The mean age was 64.3±13.2 years, 56.8 % (54/95) were male and 43.2 % (41/95) female. Mean OS in the entire cohort was 9 months. After stratification for adjuvant treatment a higher median OS was found in the group with adjuvant treatment (7 months, range 2-88) compared to the group without treatment (1 month, range 1-5) Log-rank test, p<0.0001.Conclusion: Patients with inoperable GBM undergoing biopsy indeed experience a very limited OS. Adjuvant treatment is associated with significantly longer OS compared to patients not receiving treatment and should be considered, especially in younger patients with good clinical condition at presentation.
Immune Checkpoint Inhibitor Therapy for Recurrent Meningiomas: A Retrospective Chart Review
Authors: Nidamanuri Priya , Drappatz Jan 
Published: December 2021

Abstract
Introduction: Meningiomas that progress after surgery and radiotherapy represent an unmet medical need. Expression of PD-1 and PDL-1 has been demonstrated in meningiomas and is proportional to tumor grade, suggesting a potential role for anti-PD-1/anti-PDL-1 inhibitor therapy. We explored the efficacy of immune checkpoint inhibitor therapy for recurrent meningiomas with primary endpoints of progression-free survival (PFS) and overall survival (OS).Methods: This is a retrospective chart review of patients with meningioma who were treated with PD-1 inhibitors at UPMC Hillman Cancer Center. Any patient over age 18 who received immunotherapy was included in this study. Patients received treatment until development of disease progression, intolerable toxicities or adverse events, death, or oncologist decision. Serial radiographic assessments were made every 3-6 months.Results: Between January 2015 and November 2021, eight patients received anti-PD-1 therapy. All patients underwent tumor resection and radiosurgery, and four patients received prior systemic therapy. Six out of eight patients experienced symptomatic perilesional edema and three patients experienced exacerbation of seizures. Median PFS was 7 months (95% CI 1-24) and median OS was 1.75 years (95% CI 1.5-4.0). In patients with positive PD-1 or PD-L1 expression, median PFS was 2 years and median OS was 3 years.Conclusion: Anti-PD-1 therapy was associated with a manageable safety profile in patients with recurrent meningiomas. Patients with WHO Grade III tumors and positive PD-1/PD-L1 expression were noted to have increased PFS and OS, suggesting a potential role for immunotherapy in this specific subset of patients. Further studies are needed to investigate this in a larger patient population.
Habitually Barefoot Children Inadvertently Resigned To Wear Ill-Fitting School Shoes: A Cross-Sectional Study
Authors: Breet Marise Carina , Venter Ranel 
Published: December 2021

Abstract
Background

Research shows that ill-fitting shoes can negatively impact the development of the pediatric foot, in a very direct manner. The primary aim of the study was to determine if the dimensions of available prescribed school shoes fit the foot dimensions of habitually barefoot South African children and adolescents.
Methods

A cross-sectional observational study was conducted where static standing foot measurements of children and adolescents from urban and rural schools were obtained with a mobile caliper. The maximum heel-toe-length (HTL) and foot width (FW) with an added 10 mm (millimetres) toe and width fit allowance to each participant, were compared to the corresponding school shoe length and shoe width available in retail. A mixed model ANOVA was used to compare foot dimensions between gender, age and side.
Results

Six hundred and ninety-eight school children (N=698) (431 girls; 267 boys; average age 10.86 years, SD=2.55) were participants. A total of seventy-seven (N=77) black coloured prescribed school shoes currently available in retail ranging from different styles and brands were measured. Results show that, comparing the shoe length (SL) and HTL of participants, as well as taking a10 mm toe allowance into account, fifty-nine percent (59%) of children wore shoes that were not the correct length. With regards to the shoe width (SW) and the added 10 mm of width fit allowance, ninety-eight percent (98%) of the shoes worn by participants were too narrow for their feet.
Conclusions

Results confirmed that school shoes currently available in retail, are not suited for the habitually barefoot population studied. It is recommended that the shoe manufacturing industry should consider the shoe width of school shoes for children and adolescents in habitually barefoot populations to avoid the long-term negative effect of ill-fitting shoes on the pediatric foot.