bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Human Salivary Proteome Wiki: A Community-Driven Research Platform
Authors: Lau W.W. , Hardt M. , Zhang Y.H. , Freire M. , Ruhl S. 
Published: May 2021

Saliva has become an attractive body fluid for on-site, remote, and real-time monitoring of oral and systemic health. At the same time, the scientific community needs a saliva-centered information platform that keeps pace with the rapid accumulation of new data and knowledge by annotating, refining, and updating the salivary proteome catalog. We developed the Human Salivary Proteome (HSP) Wiki as a public data platform for researching and retrieving custom-curated data and knowledge on the saliva proteome. The HSP Wiki is dynamically compiled and updated based on published saliva proteome studies and up-to-date protein reference records. It integrates a wide range of available information by funneling in data from established external protein, genome, transcriptome, and glycome databases. In addition, the HSP Wiki incorporates data from human disease–related studies. Users can explore the proteome of saliva simply by browsing the database, querying the available data, performing comparisons of data sets, and annotating existing protein entries using a simple, intuitive interface. The annotation process includes both user feedback and curator committee review to ensure the quality and validity of each entry. Here, we present the first overview of features and functions the HSP Wiki offers. As a saliva proteome–centric, publicly accessible database, the HSP Wiki will advance the knowledge of saliva composition and function in health and disease for users across a wide range of disciplines. As a community-based data- and knowledgebase, the HSP Wiki will serve as a worldwide platform to exchange salivary proteome information, inspire novel research ideas, and foster cross-discipline collaborations. The HSP Wiki will pave the way for harnessing the full potential of the salivary proteome for diagnosis, risk prediction, therapy of oral and systemic diseases, and preparedness for emerging infectious diseases. Database URL: https://salivaryproteome.nidcr.nih.gov/
Comparison of a Handheld Device vs Endotracheal Tube–Based Neuromonitoring for Recurrent Laryngeal Nerve Stimulation
Authors: Kong Derek Kai , Kong Amanda M. , Chai Raymond L. 
Published: May 2021

ObjectiveTo measure the effect of thyroidectomy difficulty on intraoperative neuromonitoring false loss of signal (LOS) and to compare intraoperative endotracheal tube–based neuromonitoring (ETNM) and Checkpoint palpation‐based direct stimulation (pDS) signals with postoperative laryngoscopy. We hypothesized that pDS has higher a positive predictive value for postdissection confirmation of recurrent laryngeal nerve function than ETNM and that this difference is accentuated with increasing thyroidectomy difficulty.Study DesignProspective single‐arm cross‐sectional study comparing ETNM and pDS for patients undergoing hemi‐, total, or completion thyroidectomy from July 2018 to March 2020.SettingSingle‐surgeon series at a tertiary care hospital.MethodsPercentage concordance and positive and negative predictive values were measured. Each thyroidectomy was assigned a validated thyroidectomy difficulty score, and recorded recurrent laryngeal nerve signals were compared with postoperative vocal fold mobility.ResultsPercentage concordance was 90.09%. Positive and negative predictive values were 0.19 (95% CI, 0.09‐0.31) and 1.0 for ETNM and 0.59 (95% CI, 0.35‐0.82) and 1.0 for pDS. The difference in positive predictive value was significant (0.40 [95% CI, 0.33‐0.47], P <. 001). False LOS rates for ETNM and pDS were 13.19% versus 3.30% (9.89% [95% CI, 1.80%‐18.62%], P =. 0155), 44.11% versus 0% (44.11% [95% CI, 25.80%‐60.54%], P <. 001), and 73.33% versus 13.33% (60% [95% CI, 24.76%‐78.46%], P =. 001) for the second through fourth thyroidectomy difficulty score quartiles, respectively. False LOS with ETNM was linearly correlated with increasing difficulty (R2 = 0.97).ConclusionETNM was subject to high rates of postdissection false LOS that increased with thyroidectomy difficulty score. pDS is a reliable alternative that has higher positive predictive value than ETNM, particularly in more challenging cases such as those with posteriorly fixed thyroid cancers and fibrotic glands.Evidence level2.
Sensing scalarity: Towards a humanistic approach to scale
Authors: Linder Benjamin 
Published: May 2021

This article develops the notion of “sense of scale” to theorize the emotional, tactile, and affective (re)production of scalarity during the coronavirus pandemic. The pandemic’s geographic upheavals – from personal proxemics to international travel bans – call for a return to scale that attends to its experiential qualities. Scale is continually conjured, apprehended, and (re)configured through proximal feelings and sensory encounters. After charting some conceptual foundations, subsequent sections discuss the relational transformation of the domestic, global, and urban scales under COVID-19. “Sense of scale” enables (post)humanistic theorizations of scale to take shape and also highlights the importance of scale for understanding everyday life.
Sexual Orientation Identity and Its Implication in the Disparities in Psychological Health-Related Quality of Life
Authors: Xie Hui , Li Yannan , Turner Cailtin 
Published: May 2021

Purpose: To examine disparities in psychological health-related quality of life (HRQoL) among sexual minority women within racial/ethnic subgroups. Design: A secondary analysis of the 2018 Behavioral Risk Factor Surveillance Survey (BRFSS). Setting: United States. Subjects: Noninstitutionalized, cisgender, adult women in the U.S (unweighted n = 81,947). Measures: Socioeconomics, health behaviors, and healthcare access as risk factors, whereas 1 item measures psychological HRQoL as an outcome. Analysis: Weighted multivariable logistic regressions to estimate the odds of having adversely psychological HRQoL in relation to sexual orientation and other correlates within a racial/ethnic subgroup independently. Results: The prevalence of adverse psychological HRQoL was greater in bisexual and “other” sexual orientation women. Both bisexual (adjusted odds ratio [aOR] = 1.58; 95% confidence interval [CI] = 1.26-2.00) and “other” sexual orientation (Aor = 1.93; 95%CI = 1.26-2.96) had greater adjusted odds of adversely psychological HRQoLcompared to their heterosexual peers in non-Hispanic White women. Bisexual women (aOR = 3.42; 95%CI = 1.98-5.88) had greater adjusted odds of adversely psychological HRQoLcompared to their heterosexual peers in Latinas. No similar pattern was observed in non-Hispanic Black women. Conclusion: Disparities in psychological HRQoL varied by sexual orientation identities within different racial/ethnic subgroups. The magnitude of the association for Latina bisexual women was strong. Implications for bisexual health among people with intersecting identities are discussed.
An Analysis of Factors Affecting Private Expenditure on Education in India
Authors: Mukherjee Ananda , Sengupta Sarbajit 
Published: May 2021

Private expenditure on education is a determining factor for ensuring an individual’s educational progress. Though the government provides a vast infrastructure at minimal cost, the individuals have to incur cost from their pockets for various purposes. In this study, we have analysed the various influences on private expenditure on education based on National Sample Survey 71st round conducted in 2014. We have found that household consumer expenditure, respondent’s age, medium of instruction dummy, private coaching dummy and household computer dummy affect private expenditure on education positively, and household size, rural dummy, female dummy, social group dummies, minority religion dummy and type of school dummy affect private expenditure on education negatively. The important policy implications are the tendency to spend less for the female child needs to be amended and the male and female child needs to be given same preference when it comes to expenditure on education. Family planning should be implemented effectively to keep the household size reasonably small for better educational access of an individual. The weaker social groups such as STs, SCs and OBCs and the minorities should be supported well by scholarships and stipends for furthering their education. The number of government institutions should increase to provide low-cost education to society. English medium schools should be made to offer more seats for the financially weak. Private coaching should be made as redundant as possible by improving teaching in the schools. For having computer in households, the financially weak should get some subsidy or may be community computer centres can cater to their needs at reduced cost or free of cost. JEL: I25, I22
The ethylene oxide sterilised Opera acetabular component demonstrates high rates of loosening and revision compared to the gamma irradiated Ogee cup: a cohort study demonstrating potential shortcomings of revision-based registry data
Authors: Baryeh Kwaku W , Bennett Kate , Sochart David H 
Published: May 2021

Aims: To evaluate the long-term clinical outcomes of 2 cemented ultra-high molecular weight polyethylene (UHMWPE) acetabular components, with the main difference between the 2 components being their method of sterilisation. Patients and methods: Data was collected prospectively on 352 consecutive total hip replacements, performed between March 2000 and July 2004, at a single centre. A posterior approach was used with a cemented C-Stem femoral component (DePuy, Warsaw, IN, USA) in all cases and either the Ogee (DePuy, Warsaw, IN, USA) or the Opera (Smith & Nephew, Memphis, TN, USA) acetabular implant. Patients were reviewed clinically and radiologically with a median 12-year follow-up (6–16 years). Results: The risk of experiencing loosening was 90% lower for the Gamma irradiated implant (GII) group compared to the ethylene oxide sterilised implant (EOSI) group, which was statistically significant ( p = 0.003), (HR 0.10; 95% CI, 0.02–0.45). The incidence of cup revision was also lower in the GII group ( p = 0.029), but after adjustment for age, gender and BMI was not statistically significant ( p = 0.104). 15-year survivorship with failure/loosening as an endpoint was 70.1% for the EOS implant and 92.9% for the GII (OR 4.99; CI 95%, 1.75–14.2) and with revision as an endpoint was 81.4% for the EOSI and 92.9% for the GII (OR 2.60; CI 95%, 0.87–7.75) Conclusions: We report increased rates of loosening, revision and failure for the EOSI compared to the GII at long-term follow-up. This may have been attributable to the different sterilisation methods used.
Measuring parent strategy use in early intervention: Reliability and validity of the Naturalistic Developmental Behavioral Intervention Fidelity Rating Scale across strategy types
Authors: Sone Bailey J , Kaat Aaron J , Roberts Megan Y 
Published: May 2021

Children with autism spectrum disorder benefit from early, intensive interventions to improve social communication, and parent-implemented interventions are a feasible, family-centered way to increase treatment dosage. The success of such interventions is dependent on a parent’s ability to implement the strategies with fidelity. However, measurement of parent strategy use varies across studies. Most studies use one of two types of observational coding measures (macro- and micro-codes). Macro-codes are known for being efficient while micro-codes are known for being precise. This study evaluates the reliability and validity of the NDBI-Fi, a macro-code, compared to a micro-code. Parent–child interaction videos for 177 participants were used to compare these measures. Results demonstrated that the NDBI-Fi had strong inter-rater reliability. It also had strong convergent validity with the micro-code after intervention. In addition, the NDBI-Fi was sensitive to change, and it demonstrated precision comparable to the micro-code. Furthermore, a novel scoring procedure detected differences in parents who learned different intervention strategy types. However, the NDBI-Fi did not demonstrate strong validity before intervention, particularly when measuring responsive intervention strategies. Taken together, findings support the use of the NDBI-Fi as an outcome measure, and future work should focus on continued development of valid pre-intervention macro-codes. Lay abstract Children with autism spectrum disorder benefit from early intervention to improve social communication, and parent-implemented interventions are a feasible and family-centered way to increase the amount of treatment they receive. For these treatments to be effective, it is important for the parent to implement the strategies as intended. However, measurement of parent strategy use is inconsistent across studies of parent-implemented interventions. This study evaluates the quality of the NDBI-Fi, an efficient measure, compared to a more time-consuming measure that is known to be precise. Videos of parents playing with their children were used to compare these two measurement methods. Results demonstrated that the NDBI-Fi was of good quality: scorers had high levels of agreement, the NDBI-Fi was similar to the more precise measure in rating parents after intervention, it detected changes from before to after intervention, and it detected differences when parents learned different types of intervention strategies. The NDBI-Fi was not as precise as the other measure across all strategies before parents learned intervention. Taken together, the findings of this study support the use of the NDBI-Fi as a high-quality outcome measure.
The relationship between sensory reactivity, intolerance of uncertainty and anxiety subtypes in preschool-age autistic children
Authors: MacLennan Keren , Rossow Timothy , Tavassoli Teresa 
Published: May 2021

Sensory reactivity differences are a diagnostic criterion of autism. Sensory hyperreactivity has been linked to intolerance of uncertainty and anxiety in autistic children. However, research is yet to explore the mediating relationships or sensory hyporeactivity, seeking and anxiety subtypes in preschool-age autistic children. Therefore, we aimed to elucidate the relationships between sensory reactivity, intolerance of uncertainty and anxiety subtypes in a heterogeneous group of 54 preschool-age autistic children, age 3–5 years, using observation and parent-report assessments. Correlational analysis found sensory hyperreactivity, intolerance of uncertainty and total anxiety were significantly intercorrelated. In addition, sensory hyperreactivity was significantly correlated with separation anxiety when controlling for autism traits. Serial mediation analyses indicated significant full mediation between sensory hyperreactivity and anxiety through intolerance of uncertainty, and significant full mediation between sensory hyperreactivity and intolerance of uncertainty through anxiety. Our results suggest that sensory hyperreactivity is a key early factor in the development of anxiety, and supports that intolerance of uncertainty is an important interrelated construct in the development and maintenance of anxiety in autism. Our findings have important implications for the development of effective interventions. However, due to limitations with the measures, our research also highlights a pressing need for objective assessments of anxiety and intolerance of uncertainty that can be used with preschool-age autistic children. Lay abstract This study found links between greater sensory hyperreactivity (e.g., over-sensitive to sensory input), intolerance of uncertainty and anxiety, including separation anxiety, in autistic pre-schoolers. Sensory hyperreactivity may predict both anxiety and intolerance of uncertainty, and anxiety and intolerance of uncertainty may both be mutually important, mediating factors. These findings have implications for early anxiety interventions. But there is a pressing need for objective assessments that can be used with preschool-age autistic children.
Life-course trajectories of working conditions and successful ageing
Authors: Nilsen Charlotta , Darin-Mattsson Alexander , Hyde Martin , Wastesson Jonas W. 
Published: May 2021

Aims: As populations are ageing worldwide, it is important to identify strategies to promote successful ageing. We investigate how working conditions throughout working life are associated with successful ageing in later life. Methods: Data from two nationally representative longitudinal Swedish surveys were linked ( n=674). In 1991, respondents were asked about their first occupation, occupations at ages 25, 30, 35, 40, 45 and 50 years and their last recorded occupation. Occupations were matched with job exposure matrices to measure working conditions at each of these time points. Random effects growth curve models were used to calculate intra-individual trajectories of working conditions. Successful ageing, operationalised using an index including social and leisure activity, cognitive and physical function and the absence of diseases, was measured at follow-up in 2014 (age 70 years and older). Multivariable ordered logistic regressions were used to assess the association between trajectories of working conditions and successful ageing. Results: Intellectually stimulating work; that is, substantive complexity, in the beginning of one’s career followed by an accumulation of more intellectually stimulating work throughout working life was associated with higher levels of successful ageing. In contrast, a history of stressful, hazardous or physically demanding work was associated with lower levels of successful ageing. Conclusions: Promoting a healthy workplace, by supporting intellectually stimulating work and reducing physically demanding and stressful jobs, may contribute to successful ageing after retirement. In particular, it appears that interventions early in one’s employment career could have positive, long-term effects.
The Interaction of Diabetic Peripheral Neuropathy and Carpal Tunnel Syndrome
Authors: Naha Ushasi , Miller Adam , Patetta Michael J. , Barragan Echenique Diego M. , Mejia Alfonso , Amirouche Farid , Gonzalez Mark H. 
Published: May 2021

Background Diabetes mellitus (DM) increases the risk for carpal tunnel syndrome (CTS) and is associated with its own neuropathic complications. Diabetic peripheral neuropathy (DPN) is a common complication seen in diabetic patients. In this study, we examine the relationship between the severity of DPN and CTS. Methods Type 2 diabetic and control patients (n = 292) were recruited at a clinic visit. The Michigan Neuropathy Screening Instrument (MNSI) questionnaire was used to collect data related to peripheral neuropathy. The MNSI scores were compared for patients with CTS with and without DM in univariable and multivariable analyses. χ2 analyses were performed to quantitatively measure the associations between peripheral neuropathy and the presence of CTS. Results Of the 292 patients, 41 had CTS, and 19 of these had both CTS and DM. Of the 138 diabetic patients, 85 had peripheral neuropathy. There was no association between a diagnosis of CTS and an MNSI score indicative of peripheral neuropathy. In the diabetic population, CTS was inversely associated with DPN ( P = .017). The MNSI scores between diabetic and control patients with CTS were comparable. Conclusion The severity of peripheral neuropathy in diabetic patients with and without CTS is comparable. Diabetic patients without peripheral neuropathy have an association with higher incidence of CTS in this study, suggesting that there are disparate mechanisms causing DPN and CTS. Nevertheless, diabetes and CTS are risk factors for developing the other, and future studies should further explore how DPN and CTS differ to tailor patient interventions based on their comorbidities.
The weight of motherhood: Identifying obesity, gestational weight gain and physical activity level of Italian pregnant women
Authors: Benvenuti Maria Beatrice , Bø Kari , Draghi Simonetta , Tandoi Elisabetta , Haakstad Lene AH 
Published: May 2021

Objective: Pre-pregnancy obesity and suboptimal gestational weight gain are on the rise globally and are independently associated with several maternal and neonatal complications. A healthy lifestyle, including regular physical activity, may improve health and reduce these complications, but many women are less active and willing to engage in physical activity with advancing gestation. Therefore, the inclusion of a wider range of physical activity such as domestic chore, occupational activity and active commuting may help pregnant women to meet the physical activity recommendations of 150 min/week. Very little is known about these issues in Italy, a country with strong traditional roles regarding pregnancy and motherhood, including “la famiglia” (the family). Primary objective describes health and lifestyle behavior of pregnant Italian women. Secondary objective reports total physical activity level, recreational exercise and context of these activities from pre-pregnancy and throughout gestation in regard to gestational weight gain management. Study design: Cross-sectional study performed in one public hospital and four antenatal clinics in Italy. Participants (n = 513) completed a validated self-administered questionnaire, the Physical Activity Pregnancy Questionnaire, in gestation week 36.01 (standard deviation 2.0). Pre-pregnancy body weight (kg) was self-reported, whereas maternal weight (kg) was measured at gestation week 36. In line with current American College of Obstetricians and Gynecologists guidelines (2020), participants were categorized into regular physical activity (⩾150 min/week) or non-regular physical activity (<150 min/week). Results: Mean pre-pregnancy body-mass index was 22.8 kg/m2 (standard deviation 3.9), with 14.4% of women entering motherhood overweight and 5.3% obese. Mean gestational weight gain was 11.9 kg (standard deviation 4.1). Among those with a body-mass index ⩾25, 46.5% gained above the Institute of Medicine recommendations. With respect to recreational exercise/sport, 4.7% were active according to guidelines, whereas 82.7% accumulated ⩾150 min/week when combining exercise/sport with daily-life physical activity (commuting and occupational). Exercising ⩾150 min/week and working 100% in third trimester were associated with gestational weight gain within Institute of Medicine recommendations (p = 0.06 and p = 0.03). Conclusion: Italian pregnant women have a low exercise level, still over 80% achieved a total physical activity level ⩾150 min/week when adding occupational and commuting activities. Nearly 50% of overweight and obese women exceeded the recommended gestational weight gain during pregnancy.