bluuebunny/crossref_metadata_2025_split huggingface dataset:
MGMT promoter gene methylation and neurological scale improvement in glioma: a cohort study
Authors: Gunawan Pricilla Yani , Islam Andi Asadul , July Julius , Patelongi Ilhamjaya , Bukhari Agussalim , Massi Muhammad Nasrum 
Published: March 2021

Background: Glioma is one of the most common primary brain tumours and conveys a dismal prognosis despite aggressive treatment. Several biomarkers have been studied in the hope of yielding better diagnostic accuracy and improving patient management. Besides survival, functional and neurological disability are concerns that have no lesser importance. In 2017, a disease-specific assessment tool – the Neurologic Assessment in Neuro-Oncology (NANO) scale – was developed to measure neurologic function in neuro-oncology cases. We sought to determine biomarkers that might be associated with neurological scale improvement in glioma patients. Methods: Glioma grade II-IV patients were recruited from three major hospitals in Jakarta-Tangerang. Isocitrate dehydrogenase (IDH) mutation and O6-methylguanine-DNA methyltransferase (MGMT) promoter gene methylation were tested, as well as patients’ neurological function before surgery and three months after. Improvement in neurological scale (NANO scale) was considered positive if there was a decrement of ≥1 of the scale. Results: There were 54 patients included in the study. Mean age was 43.63 (14.723) years old, and 61.1% were male. As much as 16 (29.6%) carried a mutation in codon 132 of the IDH1 gene, and 33 (61.1%) were MGMT methylated. Median NANO scale score before and three months after surgery was 4 (0-12) and 3 (0-12), respectively. Neurological improvement was found in 44 (81.5%) of the patients. Among patients with MGMT promoter gene methylation, 90.9% showed neurological improvement (p=0.035; OR=5; 95%CI 1.122-22.272). Conclusions: Gliomas with MGMT promoter gene methylation are more likely to show neurological improvement three months after surgery.
Single-shot measurement of the nonlinear refractive index of air at 9.2 µm with a picosecond terawatt CO2 laser
Authors: Polyanskiy Mikhail N. , Babzien Marcus , Pogorelsky Igor V. , Kupfer Rotem , Vodopyanov Konstantin L. , Palmer Mark A. 
Published: March 2021

We developed a simple, accurate single-shot method to determine the nonlinear refractive index of air by measuring the evolution of the spatial shape of a laser beam propagating through the atmosphere. A distinctive feature of this new method, which relies on a modified Fresnel propagation model for data analysis, is the use of a hard aperture for producing a well-defined, high-quality beam from a comparatively non-uniform quasi-flat-top beam, which is typical for high-peak-power lasers. The nonlinear refractive index of air for a very short (2 ps) long-wave infrared (LWIR) laser pulse was measured for the first time, to the best of our knowledge, yielding

n
2

=
3.0
×

10

−
23

m

2

/

W

at 9.2 µm. This result is 40% lower than a corresponding measurement with longer (200 ps) LWIR pulses at a similar wavelength.
Prevalence of common symptoms of neonatal illness in Northwest Ethiopia: A repeated measure cross-sectional study
Authors: Delele Tadesse Guadu , Biks Gashaw Andargie , Abebe Solomon Mekonnen , Kebede Zemene Tigabu 
Published: March 2021

Background
The neonatal period is the most vulnerable stage of life. In Ethiopia, neonatal illness is common and the reduction in neonatal mortality is not as significant as for under-five mortality.

Objectives
To determine the prevalence and factors associated with neonatal illness symptoms reported by mothers delivering in health facilities in Northwest Ethiopia.

Methods
A repeated measure cross-sectional study design was employed to collect data from 358 randomly selected deliveries in 11 health facilities from November 2018 to March 2019. A pretested and interviewer-administered structured questionnaire adapted from the literature was employed to record neonatal outcomes (illnesses and/or deaths) at birth, 24 hours, 7th, 14th and 28th day from birth. Cleaned data was exported to STATA version 14 software for analysis. Multilevel analysis was used to identify individual and facility-level characteristics associated with neonatal illness symptoms.

Results
The prevalence of neonatal illness symptoms was 27.8% (95% CI; 23.2, 32.8) of the 338 babies born alive and the neonatal mortality rate was 41/1000 live births (14/338). The most common symptoms or conditions of neonatal illness reported by mothers’ in the study area were possible serious bacterial infections (95.8%, 90/94), localized bacterial infections (43.6%, 41/94), low birth weight (23.4%, 22/94), diarrhea (18.1%, 17/94), prematurity (14.9%, 14/94), and jaundice (7.5%, 7/94). Among the babies who died, neonates who had possible serious bacterial infections, low birth weight, localized bacterial infections, and prematurity took the highest proportions with 100% (14/14), 64.3% (9/14), 50% (7/14), and 42.9% (6/14), respectively. Having a maximum of 3 children (AOR = 1.96; 95% CI = 1.1–3.6), having twins or triplets during pregnancy (AOR = 2.43; 95% CI = 1.1–6.1), and lack of antenatal counseling (AOR = 1.83; 95% CI = 1.1–3.3) were among the maternal factors associated with neonatal illness. Having low birth length (AOR = 7.93; 95% CI = 3.6–17.3), and having a poor breastfeeding quality (AOR = 2.37; 95% CI = 1.4–4.0) were found to be the neonatal factors associated with neonatal illness.

Conclusions
This study indicated a high prevalence of neonatal illness symptoms in Northwest Ethiopia. Therefore, early detection, referral and better management of symptoms or conditions with a high mortality, like sepsis and low birth weight are compulsory to save the lives of many neonates. Strengthening the health extension programme to improve antenatal care service utilization and breastfeeding quality of neonates among postpartum women is crucial.
Combustible cigarettes, heated tobacco products, combined product use, and periodontal disease: A cross-sectional JASTIS study
Authors: Yoshioka Takashi , Tabuchi Takahiro 
Published: March 2021

Background
Combustible cigarettes have detrimental effects on periodontal disease. However, little evidence is available regarding new heated tobacco product (HTP) use and combined product use (both combustible cigarettes and HTPs). This study aimed to examine the association of combustible cigarettes, HTPs, and combined product use with periodontal disease simultaneously.

Materials and methods
This cross-sectional study was conducted using data from the 2019 arm of the longitudinal Japan “Society and New Tobacco” Internet Survey. Combustible cigarette users, HTP users, combined product users, never-users, and former users’ data were separately obtained. In the present study, the primary outcome was self-reported periodontal disease. We estimated adjusted prevalence ratios (PRs) and confidence intervals (CIs) using multivariable modified Poisson regression analysis after adjusting for 12 confounders.

Results
Of the 10,439 JASTIS respondents, the numbers of users of combustible cigarettes only, HTPs only, and both products were 1,304, 437, and 1,049, respectively. Compared with never-users, HTP use was significantly associated with the prevalence of self-reported periodontal diseases (PR 1.43, 95% CI 1.03–1.62). Moreover, former users, combustible cigarette users, and combined product users also showed significant associations (PR 1.56, 95% CI 1.35–1.80; PR 1.29, 95% CI 1.03–1.62; and PR 1.55, 95% CI 1.20–1.99, respectively).

Conclusions
Users of HTPs, combustible cigarettes, and combined products as well as former users were all significantly associated with a higher prevalence of periodontal diseases compared to never-users.
Clinical, immunologic and virologic outcomes of children and adolescents receiving second line anti-retroviral therapy in two referral hospitals in Addis Ababa, Ethiopia
Authors: Tekliye Endashaw , Alemayehu Tinsae , Bacha Tigist 
Published: March 2021

BackgroundEthiopia launched free access for antiretroviral therapy in 2005. The number of patients on second line antiretroviral treatment has increased with each passing year. The objectives of this study were to describe the clinical, immunological and virologic outcomes of children and adolescents receiving second line anti-retroviral therapy in two referral hospitals, Yekatit 12 and Zewditu Memorial Hospitals, in Addis Ababa, Ethiopia.MethodsThis was a hospital based retrospective cohort study conducted among children and adolescents aged 18 years and less and receiving a second line antiretroviral drugs. Data was collected using structured questionnaires. Means and percentages were used for nominal variables. Statistical analysis was made using statistical software–SPSS 23.0. Kaplan Meier analysis, long rank test and multivariate Cox proportion model were used to identify factors affecting survival.ResultsA total of 75 children and adolescents were studied with a mean age of 13.28 years (SD: 4) with a mean treatment period on second line regimens of 35.2 months (SD: 21.8 months). Forty-eight participants were experiencing successful measures (in all three parameters) for their second line anti-retroviral treatment. Ten had virologic treatment failure while seven had died. Both treatment failure and death rates were higher within the first two years of treatment. Poor treatment adherence (Adjusted hazard ratio: 5.1 (95% CI: 1.1–23.2; p-value = 0.02)) and advanced World Health Organization clinical stage at start of the second line antiretrovirals (Adjusted hazard ratio: 7.51 (95% CI: 1.35–18.02; p-value = 0.002)) correlated significantly with survival of children and adolescents receiving treatment.ConclusionsThe study describes clinical, immunological and virologic outcomes of second line antiretroviral treatment in a pediatric cohort under care in two hospitals in Addis Ababa, Ethiopia. Poor adherence and pre-treatment advanced clinical stages were predictors of survival.
Why women do not use contraceptives: Exploring the role of male out-migration
Authors: Mukherjee Saradiya , Mahapatra Bidhubhusan , Saggurti Niranjan 
Published: March 2021

Introduction
Contextual understanding of reasons for non-use of contraceptives is key to devising family planning (FP) strategies. This study aimed to understand the reasons for non-use of contraceptives among women in the context of male out-migration.

Methods
Focus Group Discussions (FGDs) were conducted in two high male out-migration districts in Bihar, namely Nawada and Gopalganj. Twenty-five FGDs were conducted with currently married women with migrant husbands, currently married men and Accredited Social Health Activists (ASHAs) during April-June 2019. Data were analysed by using a thematic approach through Atlas.ti-6.2.

Results
The reasons for contraceptive non-use in areas with high male out-migration were complex, as this included barriers to contraceptive use unique to high-migration areas and reasons commonly found in other rural settings. Non-use of contraceptives among women with migrant husbands was mostly driven by lack of contraceptive preparedness before husband’s arrival, inability to procure contraceptives due to inaccessibility to health facilities and stigma to procure when husband was away. Other migration environment related factors included low ASHA outreach, myths and side effects of contraceptives, community fertility norms and poor spousal communications around FP.

Conclusion
The reasons for non-use of contraceptives are multifaceted, complex and interlinked. Exploration of these reasons in migration context suggest that FP programs in migration affected areas need to address a range of barriers to contraceptive use at multiple levels.
Job loss and mental health during the COVID-19 lockdown: Evidence from South Africa
Authors: Posel Dorrit , Oyenubi Adeola , Kollamparambil Umakrishnan 
Published: March 2021

Objectives
Existing literature on how employment loss affects depression has struggled to address potential endogeneity bias caused by reverse causality. The COVID-19 pandemic offers a unique natural experiment because the source of unemployment is very likely to be exogenous to the individual. This study assessed the effect of job loss and job furlough on the mental health of individuals in South Africa during the COVID-19 pandemic.

Data and methods
The data for the study came from the first and second waves of the national survey, the National Income Dynamics-Coronavirus Rapid Mobile Survey (NIDS-CRAM), conducted during May-June and July-August 2020, respectively. The sample for NIDS-CRAM was drawn from an earlier national survey, conducted in 2017, which had collected data on mental health. Questions on depressive symptoms during the lockdown were asked in Wave 2 of NIDS-CRAM, using a 2-question version of the Patient Health Questionnaire (PHQ-2). The PHQ-2 responses (0–6 on the discrete scale) were regrouped into four categories making the ordered logit regression model the most suited for assessing the impact of employment status on depressive symptoms.

Results
The study revealed that adults who retained paid employment during the COVID-19 lockdown had significantly lower depression scores than adults who lost employment. The benefits of employment also accumulated over time, underscoring the effect of unemployment duration on mental health. The analysis revealed no mental health benefits to being furloughed (on unpaid leave), but paid leave had a strong and significant positive effect on the mental health of adults.

Conclusions
The economic fallout of the COVID-19 pandemic resulted in unprecedented job losses, which impaired mental wellbeing significantly. Health policy responses to the crisis therefore need to focus on both physical and mental health interventions.
Digital inequalities in health information seeking behaviors and experiences in the age of web 2.0: A population-based study in Hong Kong
Authors: Guo Ningyuan , Guo Ziqiu , Zhao Shengzhi , Ho Sai Yin , Fong Daniel Yee Tak , Lai Agnes Yuen Kwan , Chan Sophia Siu-chee , Wang Man Ping , Lam Tai Hing 
Published: March 2021

Background
Inequalities in health information seeking behaviors (HISBs) using mass media and internet websites (web 1.0) are well documented. Little is known about web 2.0 such as social networking sites (SNS) and instant messaging (IM) and experiences of HISBs.

Methods
We surveyed representative Hong Kong Chinese adults (N = 10143, 54.9% female; 72.3% aged 25–64 years) on frequency of HISBs using traditional sources, internet websites, SNS (e.g., Facebook, Twitter), and IM (e.g., WhatsApp, WeChat) and experiences measured using Information Seeking Experience Scale. Adjusted prevalence ratios (aPRs) for HISBs and experiences by sociodemographic and health-related characteristics were yielded using multivariable Poisson regression with robust variance estimators. aPRs for experiences by HISBs using internet websites, SNS, and IM adjusting for sociodemographic and health-related characteristics were also yielded.

Results
Being female, higher educational attainment, not smoking, and being physically active were associated with HISBs using any source (all P<0.05). Older age had decreased aPRs for HISBs using traditional sources (P for trend = 0.03), internet websites (P for trend<0.001), and SNS (P for trend<0.001) but not for IM (aged 45–64 years: aPR = 1.48, 95% CI 1.07, 2.03). Lower educational attainment and income were associated with negative experiences including feelings of effort and difficulties in understanding the information (all P for trend<0.05). Older age had increased aPRs for difficulties in understanding the information (P for trend = 0.003). Compared with internet websites, HISBs using IM was associated with feelings of frustration (aPR = 1.39, 95% CI 1.08, 1.79), difficulties in understanding the information (aPR = 1.36, 95% CI 1.12, 1.65), and quality concern (aPR = 1.20, 95% CI 1.08, 1.32).

Conclusions
We identified correlates of web-based health information seeking and experiences in Hong Kong Chinese adults. Providing greater access to and improved information environment of web 2.0 to the target groups may help address digital inequalities.
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
Authors: De Giorgi Riccardo , De Crescenzo Franco , Rizzo Pesci Nicola , Martens Marieke , Howard Wendy , Cowen Philip J. , Harmer Catherine J. 
Published: March 2021

Background
The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and anti-oxidant properties which have been shown to be relevant to the pathophysiology of depression. This study assesses the efficacy, acceptability, tolerability, and safety of statins in major depressive disorder.

Methods
Our study is an update and extension of a previous meta-analysis published in 2016 by Salagre et al. We performed a systematic review (PubMed/MEDLINE, Cochrane CENTRAL, ISI Web of Science, CINAHL, and ClinicalTrials.gov until the 1st September 2020) and meta-analysis of randomized controlled trials using any statin against placebo or any other statin in the treatment of major depressive disorder. Our primary efficacy outcome measure was the mean value on any standardized scale for depressive symptoms at 8 weeks of treatment. We also calculated outcomes for efficacy, response, and remission at 2, 4, and 12 weeks, as well as acceptability (dropouts for any cause), tolerability (dropouts due to any adverse event), and safety (any adverse event) outcomes at the studies’ endpoints. Furthermore, we conducted an exploratory network meta-analysis for the primary efficacy outcome to identify potential differences between statins.

Results
We retrieved five randomized controlled trials meeting our inclusion criteria: four used a statin in addition to an antidepressant and compared it to placebo plus antidepressant, and one compared two statins alone. and one comparing one statin with another. Statins compared to placebo in addition to antidepressants were efficacious at 8 weeks (N = 255, SMD = -0.48, 95% CI = -0.74 to -0. 22) and 12 weeks (N = 134, SMD = -0.47, 95% CI = -0.89 to -0.05, moderate certainty) with no difference for acceptability, tolerability, and safety (low certainty). An exploratory network meta-analysis suggested that the most lipophilic statins, especially simvastatin, could be more efficacious than less lipophilic or hydrophilic molecules.

Conclusions
This systematic review suggests the efficacy, acceptability, tolerability, and safety of statins in addition to antidepressants in patients with major depressive disorder. Further clinical trials in different settings are required to test this result.

Trial rgistration
PROSPERO registration: CRD42020170938.
DESCARTE ADEQUADO DE MEDICAMENTOS: UMA ESTRATÉGIA INTEGRADA DE EDUCAÇÃO EM SAÚDE VOLTADA À COMUNIDADE ACADÊMICA
Authors: Neres João Pedro Granjeiro , Dos Santos Maressa Irene , Santos Elizabeth Cristina Gomes dos , Melo Menilla Maria Alves de 
Published: March 2021

O farmacêutico é o profissional responsável por orientar a comunidade sobre o uso racional de medicamentos, por meio da atenção farmacêutica. A prática da automedicação está relacionada ao estoque em domicílio de medicamentos, que favorece à problemática de seu descarte incorreto. Quando vencidos ou fora de uso, os medicamentos são descartados, na maioria das vezes, em locais inapropriados, afetando o meio ambiente. O trabalho teve por objetivo elaborar uma estratégia de descarte consciente de medicamentos durante a semana científica em uma faculdade privada, na cidade de Natal, RN, bem como avaliar o perfil dos medicamentos descartados. Trata-se de um estudo quantitativo, observacional e descritivo. A coleta dos medicamentos ocorreu em junho de 2019, durante a semana científica. Posteriormente foi realizada a contagem dos medicamentos recolhidos, separando-os por forma farmacêutica e em seguida verificou-se o quantitativo de medicamentos genéricos. Um total de 303 medicamentos vencidos ou fora de uso foram recolhidos, sendo 220 na forma farmacêutica sólida, 66 líquidos, e 17 semissólidos. Do total recolhido, apenas 51 eram genéricos. O estabelecimento de estratégias que facilitem o descarte racional de medicamentos no âmbito acadêmico possibilita uma alternativa para diminuir o acúmulo de medicamentos vencidos ou fora de uso em domicílio, bem como evita que estes sejam descartados em locais inapropriados.
Effects of river water inflow on the growth, photosynthesis, and respiration of the tropical seagrass Halophila ovalis
Authors: Lamit Nadhirah , Tanaka Yasuaki 
Published: March 2021

Abstract
To investigate the effects of river waters on estuarine seagrass, the tropical seagrass Halophila ovalis was collected at Brunei Bay, Borneo, and was cultured under laboratory conditions for 18 days. Three treatments were set up in the experiment: natural seawater with a salinity 30 (S30), estuarine river water with a salinity 10 (S10), and the intermediate water that was composed of the seawater and river water with a salinity 20 (S20). New leaf production, the average length of new leaves, rhizome elongation, and photosynthetic rate of H. ovalis were significantly higher in S20 than S10. Chlorophyll a (chl a) and carotenoid content in H. ovalis were significantly lower in S10 than S20 and S30. Though the tropical river waters could potentially cause both positive and negative effects on seagrass, the present results suggested that low salinity would be the most influential factor to hinder the growth and metabolism of H. ovalis, and the salinity threshold was observed between 10 and 20. These results suggested that H. ovalis may be able to extend its present distribution to the upper estuary at this study site in the future.
Efficacy and safety of therapeutic plasma exchange in stiff person syndrome
Authors: Czempik Piotr F. , Gawryluk Justyna , Wiórek Agnieszka , Krzystanek Ewa , Krzych Łukasz J. 
Published: March 2021

Abstract
The stiff person syndrome (SPS) is an extremely rare neurological disorder with primarily immune-mediated etiology. The cardinal symptoms are progressive, fluctuating axial/proximal limb muscle stiffness and spasms. The diagnosis is based on the clinical picture, electromyography examination and detection of antibodies to glutamic acid decarboxylase (anti-GAD). Adverse effects of medications might preclude its use or increase in dosing, therefore symptomatic and/or immunomodulatory medical therapy might be ineffective in acute exacerbation of the disease. We present a case of a 49-year-old female with exacerbation of SPS, in whom some standard pharmacotherapy could not be introduced (clonazepam, baclofen used in the past) and doses of existing standard medications could not be increased (diazepam, gabapentin, and levetiracetam) due to adverse effects. Moreover, a newly introduced medication (methylprednisolone) also led to a serious adverse effect (severe hyperglycemia). The patient underwent therapeutic plasma exchange (TPE) with good effect and no complications. We review the literature regarding the efficacy and safety profile of TPE in exacerbation of SPS unresponsive to medical therapy. The procedure seems to have a good safety profile as an adjunct therapy for exacerbation of SPS not responding to standard medical therapy in this patient population.
Crystal structure of 2-phenylethynyl-1,3,6,8-tetramethylBOPHY (BOPHY = bis(difluoroboron)-1,2-bis((1H-pyrrol-2-yl)methylene)hydrazine), C22H20B2F4N4
Authors: Liu Yingfan , Sun Saisai , Ji Guangqian , Li Xiaochuan , Son Young-A 
Published: March 2021

Abstract
C22H20B2F4N4, orthorhombic, Pbca (no. 61), a = 9.2506(2) Å, b = 36.1677(13) Å, c = 12.9475(3) Å, V = 4331.9 Å3, Z = 8, R

gt
(F) = 0.0729, wR

ref
(F
2) = 0.1992, T = 294.4 K.