bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbedaan Usia Terhadap Posisi Foramen Mentalis Panoramik di RSGM TNI AL Yos Sudarso Makassar Tahun 2018
Authors: Mattalitti St. Fadhillah Oemar , Lestari Nurasisa , Pertiwisari Amanah , Bima Lukman , Husein Husnah , Idul Indira Ayu Suryandari 
Published: April 2021

Pendahuluan: Foramen mentalis adalah bagian dari struktur anatomi mandibula yang terdapat pada kedua sisi mandibula. Identifikasi dan pemahaman posisi foramen mentalis secara klinis sangat penting dalam praktik kedokteran gigi antara lain untuk kepentingan anastesi, perawatan fraktur area parasimfisis, osteotomi untuk keperluan ortodontik, penempatan implan serta dalam bidang forensik kedokteran gigi dapat membantu mengidentifikasi Victim (Korban) yang tidak diketahui identitasnya dalam menentukan usianya. Tujuan Penelitian: Untuk mengetahui perbedaan usia terhadap posisi foramen mentalis dari gambaran radiografi panoramik pada pasien di RSGM Ladokgi TNI AL Yos Sudarso. Bahan dan Metode: Foto Panoramik, CD Room, DVD Writer, form penelitian, dan Software ImageJ. Jenis penelitian observasional analitik dengan desain cross sectional study. Uji statistik yang digunakan adalah uji Kruskal Wallis. Hasil: Penelitian ini menunjukkan usia 20-44 tahun lebih banyak berkunjung ke dokter gigi untuk memeriksakan kesehatan giginya. Adapun posisi foramen mentalis ditemukan paling banyak di posisi 4 yaitu di bawah premolar 2, lalu diikuti oleh posisi 5 yaitu di antara premolar 2 dan molar 1. Berdasarkan hasil uji Kruskal Wallis, didapatkan nilai p = 0.191 > a = 0.05 untuk regio kanan dan untuk regio kiri memiliki nilai siginifikansi perbedaan p = 0.482 > a = 0.05. Kesimpulan: Penelitian ini menunjukkan bahwa tidak terdapat perbedaan usia terhadap posisi foramen mentalis ditinjau dari gambaran radiografi panoramik di RSGM Ladokgi TNI AL Yos Sudarso Makassar.
Alteration of Gut Microbiome and Correlated Lipid Metabolism in Post-Stroke Depression
Authors: Jiang Wenxia , Gong Lei , Liu Fang , Ren Yikun , Mu Jun 
Published: April 2021

BackgroundThe pathogenesis of post-stroke depression (PSD) remains largely unknown. There is growing evidence indicating that gut microbiota participates in the development of brain diseases through the gut-brain axis. Here, we aim to determine whether and how microbial composition and function altered among control, stroke and PSD rats.Materials and MethodsAfter the PSD rat model was successfully established, gut microbiome combined with fecal metabolome approach were performed to identify potentially PSD-related gut microbes and their functional metabolites. Then, correlations between behavior indices and altered gut microbes, as well as correlations between altered gut microbial operational taxonomic units (OTUs) with differential metabolites in PSD rats were explored. Enrichment analysis was also conducted to uncover the crucial metabolic pathways related to PSD.ResultsAlthough there were some alterations in the microbiome and metabolism of the control and stroke rats, we found that the microbial and metabolic phenotypes of PSD rats were significantly different. The microbial composition of PSD showed a decreased species richness indices, characterized by 22 depleted OTUs mainly belonging to phylum Firmicutes, genus Blautia and Streptococcus. In addition, PSD was associated with disturbances of fecal metabolomics, among them Glutamate, Maleic acid, 5-Methyluridine, Gallocatechin, 1,5-Anhydroglucitol, L-Kynurenine, Daidzein, Cyanoalanine, Acetyl Alanine and 5-Methoxytryptamine were significantly related to disturbed gut microbiome (P ≤ 0.01). Disordered fecal metabolomics in PSD rats mainly assigned to lipid, amino acid, carbohydrate and nucleotide metabolism. The steroid biosynthesis was particularly enriched in PSD.ConclusionsOur findings suggest that gut microbiome may participate in the development of PSD, the mechanism may be related to the regulation of lipid metabolism.
Case Report: Exceptional Response to Second Line Temozolomide Therapy in a Patient With Metastatic Adrenocortical Carcinoma
Authors: Cosentini Deborah , Turla Antonella , Carminati Ornella , Grisanti Salvatore , Ferrari Vittorio Domenico , Laganà Marta , Rosti Giovanni , Sigala Sandra , Berruti Alfredo 
Published: April 2021

BackgroundIn a recently published retrospective case series, Temozolomide was found active as second line approach in advanced ACC patients. The disease control rate obtained, however, was short-lived. We report here an ACC patient with extensive metastatic disease who obtained a remarkable long lasting response with this alkylating agent.Case Presentationa 22-year-old female patient with ACC presented at our Medical Oncology Department in poor general condition due the presence of extensive metastatic pulmonary involvement. The disease had progressed to etoposide, doxorubicin and cisplatin plus mitotane therapy. Second line temozolomide therapy was prescribed leading to a progressive improvement of patient general conditions. The disease restaging after 12 cycles revealed a complete response of lung lesions and the patient was free from progression for 14+ months.ConclusionTemozolomide therapy could be exceptionally efficacious in the management of ACC patients. The molecular mechanisms of sensitivity and resistance to this drug should be carefully studied, in order to select the patients destined to obtain a significant clinical benefit to the drug.
MD Simulations on a Well-Built Docking Model Reveal Fine Mechanical Stability and Force-Dependent Dissociation of Mac-1/GPIbα Complex
Authors: Jiang Xiaoyan , Sun Xiaoxi , Lin Jiangguo , Ling Yingchen , Fang Ying , Wu Jianhua 
Published: April 2021

Interaction of leukocyte integrin macrophage-1 antigen (Mac-1) to platelet glycoprotein Ibα (GPIbα) is critical for platelet–leukocyte crosstalk in hemostasis and inflammatory responses to vessel injuries under hemodynamic environments. The mechano-regulation and its molecular basis for binding of Mac-1 to GPIbα remain unclear, mainly coming from the lack of crystal structure of the Mac-1/GPIbα complex. We herein built a Mac-1/GPIbα complex model through a novel computer strategy, which included a flexible molecular docking and system equilibrium followed by a “force-ramp + snapback” molecular dynamics (MD) simulation. With this model, a series of “ramp-clamp” steered molecular dynamics (SMD) simulations were performed to examine the GPIbα–Mac-1 interaction under various loads. The results demonstrated that the complex was mechano-stable for both the high rupture force (&gt;250 pN) at a pulling velocity of 3 Å/ns and the conformational conservation under various constant tensile forces (≤75 pN); a catch-slip bond transition was predicted through the dissociation probability, examined with single molecular AFM measurements, reflected by the interaction energy and the interface H-bond number, and related to the force-induced allostery of the complex; besides the mutation-identified residues D222 and R218, the residues were also dominant in the binding of Mac-1 to GPIbα. This study recommended a valid computer strategy for building a likely wild-type docking model of a complex, provided a novel insight into the mechanical regulation mechanism and its molecular basis for the interaction of Mac-1 with GPIbα, and would be helpful for understanding the platelet–leukocyte interaction in hemostasis and inflammatory responses under mechano-microenvironments.
Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field
Authors: Wu Haiyang , Tong Linjian , Wang Yulin , Yan Hua , Sun Zhiming 
Published: April 2021

Background: Microbubbles are widely used as highly effective contrast agents to improve the diagnostic capability of ultrasound imaging. Mounting evidence suggests that ultrasound coupled with microbubbles has promising therapeutic applications in cancer, cardiovascular, and neurological disorders by acting as gene or drug carriers. The aim of this study was to identify the scientific output and activity related to ultrasound microbubble through bibliometric approaches.Methods: The literature related to ultrasound microbubble published between 1998 and 2019 was identified and selected from the Science Citation Index Expanded of Web of Science Core Collection on February 21, 2021. The Scopus database was also searched to validate the results and provided as supplementary material. Quantitative variables including number of publications and citations, H-index, and journal citation reports were analyzed by using Microsoft Excel 2019 and GraphPad Prism 8.0 software. VOS viewer and CiteSpace V were used to perform coauthorship, citation, co-citation, and co-occurrence analysis for countries/regions, institutions, authors, and keywords.Results: A total of 6088 publications from the WoSCC were included. The United States has made the largest contribution in this field, with the majority of publications (2090, 34.3%), citations (90,741, 46.6%), the highest H-index (138), and close collaborations with China and Canada. The most contributive institution was the University of Toronto. Professors De Jong N and Dayton P A have made great achievements in this field. However, the research cooperation between institutions and authors was relatively weak. All the studies could be divided into four clusters: “ultrasound diagnosis study,” “microbubbles’ characteristics study,” “gene therapy study,” and “drug delivery study.” The average appearing years (AAY) of keywords in the cluster “drug delivery study” was more recent than other clusters. For promising hot spots, “doxorubicin” showed a relatively latest AAY of 2015.49, followed by “nanoparticles” and “breast cancer.”Conclusion: There has been an increasing amount of scientific output on ultrasound microbubble according to the global trends, and the United States is staying ahead in this field. Collaboration between research teams still needs to be strengthened. The focus gradually shifts from “ultrasound diagnosis study” to “drug delivery study.” It is recommended to pay attention to the latest hot spots, such as “doxorubicin,” “nanoparticles,” and “breast cancer.”
Association of 5-Hydroxytryptamine 3 Receptor Antagonists With the Prognosis of Liver Failure
Authors: Chen Yuting , Sun Jingkang , Fan Xiude , Wang Xiaoyun , Zeng Lu , Zhang Xiaoge , Zhang Kun , Li Na , Han Qunying , Liu Zhengwen 
Published: April 2021

Liver failure is a severe clinical syndrome with high mortality. 5-Hydroxytryptamine 3 receptor antagonists (5-HT3RAs) can reduce liver damage in animal models. We investigated whether 5-HT3RAs may improve the prognosis of liver failure. We analyzed the 28 and 90 days mortality of liver failure patients in relation to the use of 5-HT3RAs using data from a tertiary hospital in northwest China. According to the use of 5-HT3RAs, 419 patients with liver failure (46 acute, 93 sub-acute, 44 chronic, 236 acute on chronic) were divided into 5-HT3RA group (n = 105) and control group (n = 314). 5-HT3RAs were associated with decreased 28 days (HR 0.18, 95% CI 0.10-0.34, p &lt; 0.001) and 90 days (HR 0.21, 95% CI 0.13-0.33, p &lt; 0.001) mortality. After propensity score matching (PSM) (n = 67 in each group), 5-HT3RAs were still significantly associated with reduced 28 days (HR 0.10, 95%CI 0.04-0.26, p &lt; 0.001) and 90 days (HR 0.16, 95%CI 0.08-0.31, p &lt; 0.001) mortality. 5-HT3RA group patients had significantly higher 28 and 90 days survivals than controls both before and after PSM (all p &lt; 0.001). This study shows that 5-HT3RAs are associated with increased survival of liver failure patients and thus may be used to treat liver failure if the findings are confirmed by additional studies.
Organizing Psycho-Oncological Care for Cancer Patients: The Patient’s Perspective
Authors: Schuit Anouk S. , Holtmaat Karen , van Zwieten Valesca , Aukema Eline J. , Gransier Lotte , Cuijpers Pim , Verdonck-de Leeuw Irma M. 
Published: April 2021

BackgroundCancer patients often suffer from psychological distress during or after cancer treatment, but the use of psycho-oncological care among cancer patients is limited. One of the reasons might be that the way psycho-oncological care is organized, does not fit patients’ preferences. This study aimed to obtain detailed insight into cancer patients’ preferences regarding the organization of psycho-oncological care.Methods18 semi-structured interviews were conducted among cancer patients. Patients completed psycho-oncological treatment between 2015 and 2020 at the psychology department in a general hospital or a center specialized in psychological cancer care in the Netherlands. The interview comprised questions related to preferences regarding the institute where to receive treatment, the psychologist who provides treatment, and the type of treatment, as well as questions related to experienced barriers and facilitators to receive psycho-oncological care. Interviews were digitally recorded and transcribed verbatim. Data were analyzed individually by two coders into key issues and themes.ResultsRegarding the institute, easy accessibility and prompt availability of psychol-oncological care were considered important. Regarding the psychologist, most participants had a strong preference to be treated by a psychologist specialized in cancer or other somatic diseases. Individual face-to-face therapy was preferred above other types of treatment. Several barriers were mentioned to receive psycho-oncological treatment, among which poor accessibility to psycho-oncological care, lack of knowledge on the possibilities for psycho-oncological treatment, and stigma. Most frequently mentioned facilitators were being assertive to ask for help, having a good relationship with the healthcare professional, and the integration of psycho-oncological support within medical cancer care.ConclusionFrom the patient’s perspective, the organization of psycho-oncological care for cancer patients should focus on easy accessibility and availability, delivered by specialized psychologists, and integration in medical cancer care. Online and group therapy are acceptable, but individual face-to-face therapy is preferred. It is warranted to increase awareness on psycho-oncological care targeting both patients and healthcare providers.
Confianzas y sospechas en el campo de la seguridad
Authors: Rodriguez Florencia , Castro Natalia Sofía 
Published: April 2021

En este artículo nos planteamos el objetivo de hacer una serie de reflexiones metodológicas sobre nuestras experiencias como investigadoras en el campo de la seguridad. Explicitamos algunos nudos problemáticos en torno al oficio de investigar cualitativamente en contacto directo con la policía, en parte para abrir debates y discusiones dentro del campo de las ciencias sociales, pero también a modo de reflexividad para nuestras indagaciones en curso. Adelantamos que el espíritu del artículo intenta dirimir algunos aspectos sobre el “acceso” al trabajo de campo dentro de la institución policial, tensionando la relación entre la presunta opacidad y la predisposición de sus agentes para encontrarse con nosotras y responder nuestras preguntas. Para ello, abordamos algunos momentos de nuestra pesquisa que nos permiten identificar y reflexionar en torno de nuestras estrategias para construir confianza y algunos equívocos que dan lugar a expresiones de sospecha sobre nuestra persona y nuestras intenciones.
Effect of Unit Cell Shape on Switchable Infrared Metamaterial VO
2
Absorbers/Emitters
Authors: Ren Feifei , Gu Jinxin , Wei Hang , Xu Gaoping , Zhao Jiupeng , Dou Shuliang , Li Yao 
Published: April 2021

Metamaterial absorber/emitter is an important aspect of infrared radiation manipulation. In this paper, we proposed four simple switchable infrared metamaterial absorbers/emitters with Ag/VO
2
disks on the Ag plane employing triangle, square, hexagon, and circle unit cells. The spectral absorption peaks whose intensities are above 0.99 occur at ~4
μ
m after structure optimization when VO
2
is in insulating state and disappear when VO
2
becomes metallic state. The simulated electromagnetic field reveals that the spectral absorption peaks are attributed to the excitation of magnetic polariton within the insulating VO
2
spacer layer, whose values exceed 1.59 orders of magnitude higher than the incident magnetic field. Longer resonant wavelength would be excited in square arrays because its configuration is a better carrier of charges at the same spans. For absorption stability, the absorbers/emitters with square and circular structures do not have any change with the polarization angles changing from 0° to 90°, due to the high rotational symmetric structure. And four absorbers/emitters reveal similar shifts and attenuations under different incident angles. We believed that the switchable absorber/emitter demonstrates promising applications in the sensing technology and adaptive infrared system.
Globalización, ciudadanía y educación: Auge y expansión de los marcos de referencia cosmopolitas, multiculturales y de empoderamiento individual
Authors: Ramírez Francisco O. , Meyer John W. , Wotipka Christine Min 
Published: April 2021

Desde la Segunda Guerra Mundial, la globalización cultural, política y económica ha socavado un primer modelo educacional que solo enfatiza el estado de la nación y la ciudadanía nacional. Más aún, el estudiante debe ser preparado cada vez más para funcionar como titular de derechos y persona responsable en una sociedad global, que se relaciona con otras personas sin reparar en la ciudadanía nacional. Esta sociedad global es considerada cada vez más como legítimamente muy diversa y con un carácter multicultural. Y la diversidad en la sociedad nacional es reconocida hoy como legítima y central. A nivel individual, los estudiantes deben aprender a expresar y respetar todo tipo de valores y materiales culturales únicos.
En este artículo planteamos preguntas en torno a dos cambios centrales. La primera atañe al grado en que los currículos nacionales en ciencias sociales avanzan en la dirección general de la globalización y el multiculturalismo, como corriente opuesta a la conservación de posturas más orientadas a lo nacional. Segundo, analizamos las maneras en que los currículos nacionales resuelven las tensiones entre la construcción de la nación y su ciudadanía y la preparación de los estudiantes como individuos que participan en una sociedad nacional y global diversa.
Proponemos futuros análisis para codificar y analizar los libros de texto de ciencias sociales en unos sesenta países a lo largo de los últimos cincuenta años. Estos estudios darán indicios de tendencias a nivel mundial, regional y nacional en textos. Examinarán factores nacionales y transnacionales que influencian la probabilidad de aumento de los marcos de empoderamiento cosmopolitas, multiculturales e individuales. Se analizará además las maneras en que los currículos de Estudios Sociales procuran resolver las tensiones entre la unidad nacional y la diversidad legítima supranacional y subnacional.
Echocardiographic evaluation of sepsis induced myocardial dysfunction in patients with sepsis or septic shock: a prospective cohort study
Authors: El-Oraby Marwa Ahmed , Shaban Aliaa El-Said , El-Dada Ahmed Ali , El-Badawy Abd El-Aziz Hamed 
Published: April 2021

Background: Sepsis-induced myocardial dysfunction (SIMD) occurs in 50% of septic patients and is characterized by reduced ejection fraction (EF), cardiac index, impaired contractility, and diastolic dysfunction (DD). In sepsis-induced cardiomyopathy (SICM), EF shows initial significant deterioration on the 1st day, then final improvement at the end of the study. This study evaluated the value of different parameters measured with trans-thoracic echocardiography (TTE) in the diagnosis and prognosis of SIMD in the surgical intensive care unit (SICU).
Methodology: This prospective cohort study was conducted on 100 patients, aged from 18 to 50 years admitted to SICU being affected by sepsis or septic shock. TTE parameters [EF, tricuspid annular systolic excursion (TAPSE), inferior vena cava (IVC) diameter, E/A ratio and grading of DD and hemodynamic parameters [mean arterial blood pressure (MAP), heart rate (HR), central venous pressure (CVP)] on admission, three day post-admission and after one week.
Results: The mortality rate was 45%. DD was found in 90%. The mortality group had higher DD, higher HR, and lower MAP than the surviving group, with an insignificant difference in LVEF, TAPSE, IVC, and CVP on the 3rd and 7th days. Sepsis-induced cardiomyopathy (SICM) was found in 31% of surviving patients. DD (grade III had the highest mortality followed by grade I then grade II), HR >110 bpm, and MAP < 65mmHg are independent factors that negatively affect the duration of survival significantly.
Conclusion: TTE in patients with sepsis or septic shock is vital for diagnosis and prognosis. DD, tachycardia (HR >110 bpm), and hypotension (MAP < 65mmHg) are independent predictors of mortality in those patients. Patients with SICM (little reversible impairment of LV systolic function) had a good prognosis.
Keywords: Sepsis Induced Myocardial Dysfunction, Diastolic dysfunction, Sepsis, Septic Shock
Preregistration: The study was registered in the Ethical Committee of Faculty of Medicine, Tanta University, Tanta, Egypt (approval number: 31728/08/17)
Abbreviations: SIMD–Sepsis-induced myocardial dysfunction; SICM–sepsis-induced cardiomyopathy; TTE– transthoracic echocardiogram. EF–Ejection fraction; DD–diastolic dysfunction; MD–Myocardial dysfunction; TAPSE–tricuspid annular systolic excursion; SICU–surgical intensive care unit
Citation: El-Oraby MA, Shaban AES, El-Dada AA, El-Badawy AEH. Echocardiographic evaluation of sepsis induced myocardial dysfunction in patients with sepsis or septic shock: a prospective cohort study. Anaesth pain intensive care 2021;25(2):150-162. DOI: 10.35975/apic.v25i2.1463
Received: 6 November 2020, Reviewed: 30 December 2020, Accepted: 3 February 2021
The usefulness of the transesophageal Doppler in the anesthetic management of Morgagni hernia repair - A case report
Authors: De Babo Nuno Morais , Monteiro Maria Teresa , Santos Ana Bernardino , Carreira Cludia Raquel 
Published: April 2021

Morgagni hernia in adults is a rare condition and is associated with complications such as recurrent chest infections, respiratory failure and cardiac tamponade. Its correction represents an anesthetic challenge. Intraoperative esophageal Doppler provides important information in real time about the patient’s cardiac function and vascular filling, aiding in decision making by the anesthesiologist. We report a case of a 70–year–old woman, ASA Physical Status–III, and presented with chest pain, dyspnea and hypoxemia. Her chest x-ray revealed opacification of 2/3 of the left hemithorax and 1/2 of the right. Computed tomography confirmed a bilateral Morgagni hernia. The patient underwent immediate corrective surgery. Intraoperative cardiovascular function was monitored with esophageal Doppler. Compression and decompression of thoracic structures produces enormous hemodynamic and respiratory impact. After herniated contents removal it showed an increase in systolic volume and cardiac index and a correction of flow time. Transient arterial hypotension was verified, requiring fluid therapy and vasopressor support. Diaphragmatic defect was corrected and general hemodynamic stabilization was achieved. Patient was discharged asymptomatic. The esophageal Doppler was important in this case because it allowed us to measure fundamental hemodynamic variables in real time, such as cardiac index or systolic volume, and to subsequently act accordingly.
Key words: Esophageal; Doppler; Morgagni hernia; Anesthesia
Citation: Babo NM, Monteiro MT, Santos AB, Carreira CR. The usefulness of the transesophageal Doppler in the anesthetic management of Morgagni hernia repair - A case report. Anaesth pain intensive care 2021;25(2):206-211. DOI: 10.35975/apic.v25i2.1467
Received: 19 November 2020, Reviewed: 22 December 2020, Accepted: 12 January 2021