bluuebunny/crossref_metadata_2025_split huggingface dataset:
The deubiquitinase OTUB1 fosters papillary thyroid carcinoma growth through EYA1 stabilization
Authors: Xie Peiyi , Chao Qing , Mao Jiuang , Liu Yue , Fang Jiayu , Xie Jing , Zhen Jing , Ding Yongqi , Fu Bidong , Ke Yun , Huang Da 
Published: November 2021

AbstractDeubiquitinating enzyme OTU domain‐containing ubiquitin aldehyde‐binding proteins 1 (OTUB1) has been shown to have an essential role in multiple carcinomas. However, the function of OTUB1 in papillary thyroid cancer (PTC) and the underlying mechanisms regulating PTC cells proliferation remain poorly understood. In this study, OTUB1 was significantly upregulated in papillary thyroid carcinoma tissues and cells. Through in vitro and in vivo experiments, knockdown of OTUB1 suppressed PTC cells growth whereas OTUB1 overexpression enhanced the proliferation ability of PTC cells. Moreover, the eyes absent homologue 1 (EYA1) was recognized as a potential target of OTUB1 through mass spectrometry analysis, and we further verified that EYA1 protein level was positively correlated with OTUB1 expression in PTC cells and clinical samples. Mechanistically, OTUB1 could interact with EYA1 directly and deubiquitinate EYA1 to stabilize it. At last, EYA1 was found to play an essential role in OTUB1‐derived PTC cells growth. Overall, our investigation reveals that OTUB1 is a previously unrecognized oncogenic factor in PTC cells proliferation and suggests that OTUB1 might be a novel therapeutic target in PTC.
Sustainability implications of artificial intelligence in the chemical industry: A conceptual framework
Authors: Liao Mochen , Lan Kai , Yao Yuan 
Published: November 2021

AbstractArtificial intelligence (AI) is an emerging technology that has great potential in reducing energy consumption, environmental burdens, and operational risks of chemical production. However, large‐scale applications of AI are still limited. One barrier is the lack of quantitative understandings of the potential benefits and risks of different AI applications. This study reviewed relevant AI literature and categorized those case studies by application types, impact categories, and application modes. Most studies assessed the energy, economic, and safety implications of AI applications, while few of them have evaluated the environmental impacts of AI, given the large data gaps and difficulties in choosing appropriate assessment methods. Based on the reviewed case studies in the chemical industry, we proposed a conceptual framework that encompasses approaches from industrial ecology, economics, and engineering to guide the selection of performance indicators and evaluation methods for a holistic assessment of AI's impacts. This framework could be a valuable tool to support the decision‐making related to AI in the fundamental research and practical production of chemicals. Although this study focuses on the chemical industry, the insights of the literature review and the proposed framework could be applied to AI applications in other industries and broad industrial ecology fields. In the end, this study highlights future research directions for addressing the data challenges in assessing AI's impacts and developing AI‐enhanced tools to support the sustainable development of the chemical industry.
Histopathologic and immunophenotypic profile of a spontaneous mammary carcinoma in a male Humboldt's white‐fronted capuchin (Cebus albifrons)
Authors: Carvalho Thaynara Parente de , Oliveira Ayisa Rodrigues de , Santos Daniel Oliveira dos , Cassali Geovanni Dantas , Garcia Ana Paula Vargas , Pereira Fernanda Mara Aragão Macedo , Soares‐Neto Lauro Leite , Silva Monique Ferreira , Paixão Tatiane Alves , Santos Renato Lima 
Published: November 2021

AbstractA 20‐year‐old male captive Humboldt's white‐fronted capuchin (Cebus albifrons) that died accidentally had a small non‐ulcerative mammary nodule diagnosed as a mammary carcinoma. Immunohistochemistry demonstrated that neoplastic cells were positive for pan‐cytokeratin and cytokeratin‐7. Approximately 20% of neoplastic cells were positive for Ki‐67. Neoplastic cells expressed estrogen and progesterone receptors.
Trajectories of resilience and related factors in primary caregivers of patients with advanced head and neck cancer: A longitudinal cohort study
Authors: Lee Li‐Yun , Huang Bing‐Shen , Lin Chien‐Yu , Chung Ching‐Fang , Chang Ya‐Lan , Chen Shu‐Ching 
Published: November 2021

AbstractPurposePrimary caregivers (PC) of patients with advanced head and neck cancer (HNC) report stress during caregiving time post‐treatment. We sought to identify the trajectories of resilience from initial completion of treatment to 1‐year post‐treatment in PC of patients with advanced HNC and to determine the factors associated with trajectories of resilience.DesignIn this prospective cohort study with convenience sampling, patient–PC dyads were recruited from a medical center in northern Taiwan between August 2015 and July 2020.MethodsWe recruited 120 patient–PC dyads and followed up at treatment completion and 1, 6, and 12 months post‐treatment. Generalized estimating equation analysis was performed to identified factors related to resilience.FindingsPCs’ overall resilience increased from initial completion of treatment to peak at 1‐year post‐treatment. Patient factors associated with greater overall resilience included older age, higher performance status, and shorter time since cancer diagnosis; PC factors included reporting more social support, better physical health, and better mental health.ConclusionsPC mental health was the most important factor in the resilience trajectory of patients with advanced HNC cancer.Clinical relevanceQuantifying the relevant factors of trajectories of resilience will help to identify vulnerable PCs and guide survivorship care in the early stages of the post‐treatment period.
A single‐blinded, randomized, controlled trial comparing efficacy between low‐fluence alexandrite 755‐nm picosecond laser and low‐fluence neodymium‐doped yttrium aluminum garnet (Nd:YAG) 1064‐nm picosecond laser for the treatment of ultraviolet B‐induced hyperpigmentation
Authors: Vachiramon Vasanop , Namasondhi Amornrut , Anuntrangsee Tanaporn , Jurairattanaporn Natthachat 
Published: November 2021

AbstractBackgroundHyperpigmentation is a common concern of patients in dermatology clinics. Although there are many treatment options, lasers are considered a promising therapy for various hyperpigmentary conditions.ObjectivesThis study aims to evaluate the efficacy of alexandrite 755‐nm picosecond and neodymium‐doped yttrium aluminum garnet (Nd:YAG) 1064‐nm picosecond lasers for the treatment of ultraviolet B (UVB)‐induced hyperpigmentation in Asians.Materials and MethodsA randomized, single‐blinded study was conducted. UVB‐induced hyperpigmentation was performed in three spots by narrowband UVB. After 2 weeks, these three spots were allocated into 755‐treated, 1064‐treated, and control sites. Patients received weekly laser treatments for five sessions. Follow‐ups were scheduled at 1 and 2 months after the last session.ResultsTwenty patients attended the study. Overall, 755‐nm and 1064‐nm picosecond lasers showed a significant improvement in the mean lightness index (L*) compared to the control site, which started at Day 49 and Day 77, respectively. The mean L* of the 755‐nm‐treated site was also higher than that of the 1064‐nm–treated site at Day 105 (p ≤ 0.001). Initially, the mean L*, physician's visual analog scale (VAS), and patient satisfaction with the 1064‐nm picosecond laser were better than those with the 755‐nm picosecond laser. Nevertheless, an inversion of the mean L* and VAS was noted at Day 49, whereas the mean patient satisfaction was noted at Day 77. In the subgroup analysis, a 755‐nm picosecond laser effectively treated Fitzpatrick skin types (FPTs) III and IV. However, the mean L* of the 1064‐nm picosecond laser was not significantly different from that of the control for FPT4.ConclusionThe alexandrite 755‐nm picosecond and Nd:YAG 1064‐nm picosecond lasers appear to be effective and safe modalities for treating UVB‐induced hyperpigmentation. With the setting employed in this study, the outcome after the 755‐nm picosecond laser treatment seemed superior to that of the 1064‐nm picosecond laser treatment, especially for FPT4.
Painting CROSS TCA technique: Modification of the CROSS method for the treatment of atrophic acne scars—Case series
Authors: Horovitz Tamir , Salameh Fares , Shehadeh Waseem , Koren Amir , Artzi Ofir 
Published: November 2021

AbstractBackgroundThe Chemical Reconstruction of Skin Scars (CROSS) technique was first described in 2002 and has since demonstrated safety and efficacy in multiple studies. We describe the treatment of six patients with a modified version of the CROSS method—the Painting CROSS trichloroacetic acid (TCA) technique. This technique has the advantage of offering even higher tissue selectivity and better control of the scar edges, enhancing both safety and efficacy.MethodsWe retrospectively evaluated 31 scars of six patients who underwent a single treatment by the Painting CROSS TCA method. A 0.3 ml insulin syringe with a 30‐gauge needle was filled with 0.05 ml of 85% TCA solution and then applied to the scar base with slight pressure until frosting was achieved. Patients were evaluated before and 3 months after treatment for scar volume deficit by a high‐resolution three‐dimensional imaging system.ResultsThe average volume of the 31 scars assessed in our study was 2.71 mm3 before treatment and 1.96 mm3 after treatment. There was a 26.3% average decrease in the volume of the scars after one treatment. Transient mild hyperpigmentation was noted in two patients after the treatment.ConclusionPainting CROSS TCA technique has demonstrated efficacy in the treatment of acne scars after a single treatment.
Female Representation in the Academic Finance Profession
Authors: SHERMAN MILA GETMANSKY , TOOKES HEATHER E. 
Published: November 2021

ABSTRACTWe present new data on female representation in the academic finance profession. In our sample of finance faculty at top‐100 U.S. business schools during 2009 to 2017, only 16.0% are women. The gender imbalance manifests in several ways. First, after controlling for research productivity, women hold positions at lower ranked institutions and are less likely to be full professors. Results also suggest that they are paid less. Second, women publish fewer papers. This gender gap exists in research quantity, not quality. Third, women have more female coauthors, suggesting smaller publication networks. Time‐series data suggest shrinking gender gaps in recent years.
A Randomized controlled clinical trial on dose optimization of thalidomide in maintenance treatment for recurrent aphthous stomatitis
Authors: Deng Yiwen , Wei Wei , Wang Yufeng , Pan Lei , Du Guanhuan , Yao Hui , Tang Guoyao 
Published: November 2021

AbstractBackgroundRecurrent aphthous stomatitis (RAS) is the most common oral mucosal disease, and ulcer‐free periods are a major concern for patients. Thalidomide has been shown to be an effective systemic drug in the treatment of RAS, but the value of undertaking a trial to evaluate various maintenance doses was warranted.MethodsWe performed this randomized controlled clinical trial with a two‐stage design. Firstly, all the 125 cases of RAS received prednisone at a starting dose of 15 mg/d for one week as an initial therapeutic drug. Secondly, the 100 cases of RAS in the experimental group received thalidomide (50 mg/d vs. 25 mg/d) as a maintenance drug to observe its efficacy and safety.ResultsDuring maintenance medication at the fourth and eighth weekend, the two doses (50 and 25 mg/d) of thalidomide were equivalent in reducing the incidence of ulcers, ulcer number, and ulcer pain, respectively (all p > 0.05). Notably, the ulcer‐free period in the group using 25 mg/d thalidomide for eight weeks was longer (mean, >3 months) than those in the other groups (all p < 0.05). Importantly, the total adverse events in the group using 25 mg/d thalidomide were significantly less than those in the group using 50 mg/d (p < 0.001). Moreover, the effect of 50 mg/d thalidomide on the levels of various salivary cytokines was not superior to 25 mg/d medication (p > 0.05).ConclusionThis dose optimization study concluded that 25 mg/d thalidomide had a long‐term effect on extending the recurrence interval of RAS with better safety.
Optimism, pessimism and support in older couples: A longitudinal study
Authors: Segel‐Karpas Dikla , Arbel Reout 
Published: November 2021

AbstractObjectivesOptimism is linked to varied advantageous outcomes, ranging from improved health to better relationships, while pessimism is linked to reduced well‐being. Relatively little is known about how optimism and pessimism may work together to shape the perception of support within marital relationships, and whether perceived support can affect couple‐members' optimism and pessimism.MethodWe used three waves of a nationally representative sample of older couples (N = 1681 couples), spanning a period of eight years. Partners reported perceived support, optimism, and pessimism in each wave. We used a random‐intercept cross‐lagged panel model (RI‐CLPM) to test within‐ and between‐person effects.ResultsAt the within‐person level, husbands', but not wife's, future expectations were associated with partners' perceived marital support; increases in husbands' pessimism on a given wave were related to decreases in husbands' perceived marital support at the next wave, and vice versa (i.e., actor effect). Within the same wave, increases in husbands' pessimism were associated with wives' decreased perceived marital support. At the between‐person level, both partners' optimism and pessimism were associated with marital support.DiscussionFindings suggest that changes in husbands' levels of pessimism propel marital support experiences of both partners. At the methodological level, results highlight the importance of examining interpersonal processes at both the within‐ and between‐levels of analyses, as they may yield divergent patterns.
Daily moral identity: Linkages with integrity and compassion
Authors: Krettenauer Tobias , Lefebvre Jean Paul , Hardy Sam A. , Zhang Zhiyong , Cazzell Amber R. 
Published: November 2021

AbstractObjectiveThe present study investigated how much variability in moral identity scores is attributable to individual differences that are stable over time and how much variability reflects daily fluctuations.MethodParticipants (N = 138, M age = 25.11 years, SD = 10.77; 82% female) were asked to report the self‐importance of three moral attributes (being honest, fair, and caring) once a day for 50 consecutive days. Ratings were decomposed into between‐ and within‐person variability and analyzed in relation to individuals' self‐reported feelings of integrity and compassion using hierarchical linear modelling.ResultsDaily measures of moral identity exhibited more between‐ than within‐person variability (64% vs. 36%). Furthermore, feelings of integrity and compassion were more strongly positively correlated with moral identity on the inter‐individual level than the intra‐individual level.ConclusionOverall, findings suggest that moral identity has both trait‐ and state‐like characteristics and might be best conceptualized as a characteristic adaptation evidencing both stability and change.
Parental Trust in School‐Based Health Care: A Systematic Review
Authors: Nahum Andrea S. , Vongsachang Hursuong , Friedman David S. , Collins Megan E. 
Published: November 2021

ABSTRACTBACKGROUNDHealth care delivery in schools is a frequently adopted approach to reduce health care inequalities. Lack of parental trust has been identified as impacting participation in school‐based health care programs (SBHPs). The aim of our systematic review is to outline themes related to parental trust in SBHPs.METHODSWe searched MEDLINE, Embase, CINHAL, ERIC, PsycInfo, and Web of Science for articles published between 1969 and 2019. Eligible studies (1) were peer‐reviewed primary research articles; (2) were school‐based health interventions or screening programs; (3) included parental trust data; and (4) were carried out on schoolchildren from pre‐K to grade 12. Study location, data collection date, number of participants, demographics, intervention type, study aim and methodology, and all trust themes mentioned, were extracted. Studies were critically appraised using the CASP checklist for qualitative research.RESULTSWe identified 9 themes related to parental trust in SBHPs: (1) safety; (2) effectiveness; (3) health professionals' training and credentials; (4) communication; (5) confidentiality; (6) providers; (7) government, authorities, and health service; (8) the pharmaceutical industry; and (9) research and data sharing.CONCLUSIONSThe themes identified provide a framework for examining trust in SBHPs, and may guide the development of interventions to increase trust and engagement in SBHPs.
Isolated autism is not an indication for Smith–Lemli–Opitz syndrome biochemical testing
Authors: Kaub Peter A , Sharp Peter C , Ranieri Enzo , Fletcher Janice M 
Published: November 2021

Several studies have demonstrated a high incidence of autistic spectrum features in individuals with Smith–Lemli–Opitz syndrome (SLOS). However, do these findings imply a converse relationship that has diagnostic utility? Is SLOS testing implicated when autism spectrum disorder (ASD) is the only clinical indication?AimTo determine if there is any correlation with a clinical indication of ASD and a biochemical diagnosis of SLOS, based on historical test request and assay data.MethodsSix years (2008–2013) of clinical test requests for 7‐dehydrocholesterol (7‐DHC) level were classified and summarised according to indication and final test result.ResultsFrom the audit period, 988 valid test results from post‐natal samples were identified. In plasma/serum, mean 7‐DHC level was 264.7 μmol/L (normal range < 2.0) for confirmed SLOS cases. No tests performed due to an isolated clinical indication of ASD or where no clinical information was supplied were associated with 7‐DHC levels diagnostic for SLOS.ConclusionsHistorical test data analysis supports the recommendation that autism/ASD as a single clinical feature is not an appropriate indication for SLOS (7‐DHC) biochemical testing.
Phosphorus equivalency of phytase with various evaluation indicators of duck in starter
Authors: Zhang Dingran , Xu Shujing , Xu Hongyang , Wang Xinghui , Liu Peiyao , Xu Hongrun , Qi Zhili 
Published: November 2021

AbstractThis study was conducted to evaluate phosphorus (P) equivalency of phytase with various evaluation indicators of ducks in starter (0–14 days). Three hundred and twenty 1‐day‐old Cherry Valley ducks were randomly assigned to eight groups. The dietary treatments were four levels of available phosphorus (aP) with 0.25%, 0.32%, 0.39%, and 0.46% (treatments I–IV) and four levels of phytase added to low‐aP basal diet (treatment I) with 300, 600, 900, and 1200 units (U) per kg (treatments V–VIII). The results were that compared to treatment I, increasing aP and supplementary phytase significantly (p < 0.05) improved body weight (BW), BW gain (BWG), feed intake (FI), live BW, carcass weight, semieviscerated weight, eviscerated weight, leg muscle weight, and decreased feed conversion ratio (FCR). Treatments V and VI did not significantly increase tibia ash, tibia calcium, and tibia P of 14‐day‐old ducks (p > 0.05). Following the increase of aP level (treatments I–IV), apparent utilization of Ca and P of ducks increased with varying degrees. With the increase of dietary phytase level (treatments V–VIII), the apparent utilization of Ca and P showed no significant difference (p > 0.05) but an increasing trend. Serum P reached the highest level when adding 600 U/kg phytase (treatment VI). Serum Ca and serum alkaline phosphatase activity showed no significant difference among treatments V–VIII (p > 0.05). Based on corn–soybean–rapeseed meal diet, with the evaluation indexes of FI, BWG, tibia ash, tibia Ca, tibia P, and apparent utilization of Ca and P, the addition of 500 U/kg phytase could release aP of 0.03%, 0.04%, 0.02%, 0.01%, 0.02%, 0.08%, and 0.07%, respectively. On the same way, the addition of 1000 U/kg phytase could release aP of 0.07%, 0.09%, 0.06%, 0.02%, 0.07%, 0.09%, and 0.09%, respectively.
The emerging role of small extracellular vesicles in saliva and gingival crevicular fluid as diagnostics for periodontitis
Authors: Han Pingping , Bartold Peter Mark , Ivanovski Sašo 
Published: November 2021

AbstractPeriodontitis is a highly prevalent multifactorial chronic inflammatory disease associated with a destructive host immune‐inflammatory response to microbial dysbiosis. Current clinical diagnosis is reliant on measuring past periodontal tissue loss, with a lack of molecular biomarkers to accurately diagnose periodontitis activity in ‘real‐time’. Thus, discovery of new classes of diagnostic biomarkers is of critical importance in periodontology. Small extracellular vesicles (<200 nm in diameter; sEVs) from oral biofluids (saliva and gingival crevicular fluid—GCF) are lipid‐encapsulated bilayered vesicles and have recently emerged as a potential source of biomarkers for periodontal disease (gingivitis and periodontitis), due to the cargo of protein, genetic material and lipids derived from their parent cells. There is limited information on the isolation and characterisation methods of saliva/GCF‐sEVs or the characterisation of sEVs cargo as biomarkers for periodontitis. In this review, we detail the composition of sEVs and summarise their isolation and characterisation from saliva and GCF. The potential role of saliva and GCF‐derived sEVs in periodontitis diagnosis is also explored. It is proposed that sEVs cargo, including protein, microRNA, message RNA and DNA methylation, are potential biomarkers for periodontitis with good diagnostic power (area under the curve—AUC > 0.9).
Activation of GATA‐binding protein 4 regulates monocyte chemoattractant protein‐1 and chemotaxis in periodontal ligament cells
Authors: Zhu Ningjing , Zheng Xueqing , Qiao Weiwei , Huang Wushuang , Li Ruiqi , Song Yaling 
Published: November 2021

AbstractBackground and ObjectivesPeriodontitis is a chronic inflammatory disease of periodontal supporting tissues. The persistent inflammatory reaction depends on the release of chemokines to continuously recruit inflammation cells. GATA‐binding protein 4 (GATA4) exerts effects on senescence and inflammation, while its role in periodontitis is far from clear. The present study aims to address the effect of GATA4 on regulating chemokines and the chemotaxis in periodontitis.Material and MethodsPeriodontitis rat models were constructed to detect the expression of GATA4 and the chemokine monocyte chemoattractant protein‐1 (MCP‐1) by immunohistochemistry. Lipopolysaccharide (LPS)‐stimulated human periodontal ligament (PDL) cells and GATA4‐knockdown by siRNA transient transfection PDL cells were used to explore the correlation between GATA4 and chemokines. Transwell assay was performed to detect the role of GATA4 for the recruitment effect of chemokines on macrophages. Mitogen‐activated protein kinase (MAPK) inhibitors were scheduled to intervene in LPS‐stimulated PDL cells to examine the association between MAPK signaling pathways and GATA4. The expression of GATA4, chemokines, or MAPK signaling molecules was determined by quantitative real‐time polymerase chain reaction, western blotting, or cell immunofluorescence.ResultsThe expression of GATA4 and MCP‐1 was significantly increased in periodontitis rat models and in LPS‐stimulated PDL cells. Knockdown GATA4 inhibited the expression of GATA4 and MCP‐1 as well as suppressed the recruitment of macrophage in LPS‐stimulated PDL cells. Inhibitors of p38 and ERK1/2 signaling pathways significantly downregulated the increased expression of GATA4 and MCP‐1 induced by LPS in PDL cells.ConclusionsGATA‐binding protein 4 could act as an upstream regulator of MCP‐1 and as a downstream regulator of p38 and ERK1/2 signaling pathways to initiate inflammation response and regulate chemotaxis during the progression of periodontitis.