bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mathematical Study of the Influence of Hypoxia and Acidity on the Evolutionary Dynamics of Cancer
Authors: Fiandaca Giada , Delitala Marcello , Lorenzi Tommaso 
Published: June 2021

AbstractHypoxia and acidity act as environmental stressors promoting selection for cancer cells with a more aggressive phenotype. As a result, a deeper theoretical understanding of the spatio-temporal processes that drive the adaptation of tumour cells to hypoxic and acidic microenvironments may open up new avenues of research in oncology and cancer treatment. We present a mathematical model to study the influence of hypoxia and acidity on the evolutionary dynamics of cancer cells in vascularised tumours. The model is formulated as a system of partial integro-differential equations that describe the phenotypic evolution of cancer cells in response to dynamic variations in the spatial distribution of three abiotic factors that are key players in tumour metabolism: oxygen, glucose and lactate. The results of numerical simulations of a calibrated version of the model based on real data recapitulate the eco-evolutionary spatial dynamics of tumour cells and their adaptation to hypoxic and acidic microenvironments. Moreover, such results demonstrate how nonlinear interactions between tumour cells and abiotic factors can lead to the formation of environmental gradients which select for cells with phenotypic characteristics that vary with distance from intra-tumour blood vessels, thus promoting the emergence of intra-tumour phenotypic heterogeneity. Finally, our theoretical findings reconcile the conclusions of earlier studies by showing that the order in which resistance to hypoxia and resistance to acidity arise in tumours depend on the ways in which oxygen and lactate act as environmental stressors in the evolutionary dynamics of cancer cells.
Volatile metabolites of willows determining host discrimination by adult Plagiodera versicolora
Authors: Ling Jiahao , Li Xiaoping , Yang Guo , Yin Tongming 
Published: June 2021

AbstractPlagiodera versicolora Laicharting is a highly damaging leaf beetle foraging on willow leaves. In willow germplasm collections, observation has shown that Salix suchowensis Cheng was severely foraged by this leaf beetle while Salix triandra L. was damage free or only slightly damaged. Results of olfactometer bioassays show that the headspace volatiles from leaves of S. triandra significantly repelled adult beetles, suggesting that this species produces volatile repellents against P. versicolora. S. suchowensis had no effect on the beetles. Gas chromatography-mass spectrometry was carried out to profile the headspace volatile organic compounds and 23 compounds from leaves of the alternate species in significantly different concentrations were detected. The effects of 20 chemical analogs on host discrimination were examined. Olfactory response to these chemicals showed that o-cymene, a S. suchowensis specific constituent, significantly attracted adult P. versicolora. In contrast, cis-3-hexenyl acetate, a constituent concentrated more in S. triandra than in S. suchowensis, significantly repelled beetles. Mixing o-cymene and cis-3-hexenyl acetate in comparable concentrations as in the volatiles of S. suchowensis demonstrated that the latter could mask the attracting effect of the former, causing a neutral response by adult beetles to leaves of S. suchowensis against clean air. In addition, chemical analogs have the same effect as plants when resembling volatile organic compounds in real samples. Two volatile metabolites were detected triggering host discrimination by one of the most damaging insect pests to host and non-host willows. The two metabolites are of considerable potential for use as olfactory signs in managing the beetles.
Maternal obesity and depression reported at the first antenatal visit
Authors: Tuthill Emma H. , Reynolds Ciara M. E. , McKeating Aoife , O’Malley Eimer G. , Kennelly Mairead M. , Turner Michael J. 
Published: June 2021

Abstract
Background
Maternal obesity and depression are common and both have been associated with adverse pregnancy outcomes.

Aims
The aim of this observational study was to examine the relationship between maternal body mass index (BMI) category and self-reported depression at the first antenatal visit.

Methods
Women who delivered a baby weighing ≥ 500 g over nine years 2009–2017 were included. Self-reported sociodemographic and clinical details were computerised at the first antenatal visit by a trained midwife, and maternal BMI was calculated after standardised measurement of weight and height.

Results
Of 73,266 women, 12,304 (16.7%) had obesity, 1.6% (n = 1126) reported current depression and 7.5% (n = 3277) multiparas reported a history of postnatal depression. The prevalence of self-reported maternal depression was higher in women who had obesity, > 35 years old, were socially disadvantaged, smokers, had an unplanned pregnancy and used illicit drugs. After adjustment for confounding variables, obesity was associated with an increased odds ratio (aOR) for current depression in both nulliparas (aOR 1.7, 95% CI 1.3–2.3, p < 0.001) and multiparas (aOR 1.8, 95% CI 1.5–2.1, p < 0.001) and postnatal depression in multiparas (aOR 1.4, 95% CI 1.3–1.5, p < 0.001). The prevalence of current depression was higher in women with moderate/severe obesity than in women with mild obesity (both p < 0.001).

Conclusions
We found that self-reported maternal depression in early pregnancy was independently associated with obesity. The prevalence of depression increased with the severity of obesity. Our findings highlight the need for implementation of strategies and provision of services for the prevention and treatment of both obesity and depression.
Automated Brain Masking of Fetal Functional MRI with Open Data
Authors: Rutherford Saige , Sturmfels Pascal , Angstadt Mike , Hect Jasmine , Wiens Jenna , van den Heuvel Marion I. , Scheinost Dustin , Sripada Chandra , Thomason Moriah 
Published: June 2021

AbstractFetal resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a critical new approach for characterizing brain development before birth. Despite the rapid and widespread growth of this approach, at present, we lack neuroimaging processing pipelines suited to address the unique challenges inherent in this data type. Here, we solve the most challenging processing step, rapid and accurate isolation of the fetal brain from surrounding tissue across thousands of non-stationary 3D brain volumes. Leveraging our library of 1,241 manually traced fetal fMRI images from 207 fetuses, we trained a Convolutional Neural Network (CNN) that achieved excellent performance across two held-out test sets from separate scanners and populations. Furthermore, we unite the auto-masking model with additional fMRI preprocessing steps from existing software and provide insight into our adaptation of each step. This work represents an initial advancement towards a fully comprehensive, open-source workflow, with openly shared code and data, for fetal functional MRI data preprocessing.
The digital transformation of healthcare - An interview with Werner Dorfmeister
Authors: Alt Rainer , Zimmermann Hans-Dieter 
Published: June 2021

AbstractIn this interview, Werner Dorfmeister, a Vice President at DasLab and a former Global Sales Director at Karl Storz, reports on the current developments of digital technologies in the field of medical instruments and services. It is a sector where digitalization affects all processes within hospitals as well as pre- and post-surgical activities. Due to the many actors involved, who use different information systems, and the strong regulation of the entire healthcare sector, crafting digital solutions is complex, but nevertheless promising and necessary. Among the key areas mentioned in the interview are telemedicine, hospital and patient management and a sector-wide digital infrastructure. Digital platforms are described as important enablers to address current inefficiencies and to leverage future potentials towards patient-orientation, such as digital patient pathways.
Role of thyroid hormone therapy in depressive disorders
Authors: Bauer M. , Whybrow P. C. 
Published: June 2021

Abstract
Purpose
The close association among thyroid metabolism, mood disorders and behavior has long been known. The old and modern uses of thyroid hormones to modulate the expression of depression and bipolar disorder and to improve clinical outcome when used in conjunction with psychotropic medications.

Methods
A literature search was performed to identify studies investigating the effects of thyroid hormone treatment in patient s with mood disorders.

Results
The successful modification of mood disorders with thyroid hormone underscores the association between endocrine and cerebral systems in these disorders. Thyroid hormones have a profound influence on behavior and appear to be capable of modulating the phenotypic expression of major mood disorders. In fact, there is evidence that triiodothyronine (LT3) may accelerate the antidepressant response to antidepressants, and studies suggest that LT3 also may augment the response to antidepressants in refractory depression. Add-on treatment with supraphysiologic doses of levothyroxine (LT4) has shown efficacy in open-label and in placebo-controlled studies, including in rapid cycling and prophylaxis-resistant bipolar disorder, and with acute refractory uni- or bipolar depression. Functional brain-imaging studies (PET) demonstrated that administration of supraphysiologic LT4 improves depressive symptoms in patients with bipolar depression by modulating cerebral activity in the anterior limbic network.

Conclusion
The add-on administration of supraphysiologic doses of LT4 is a promising strategy in patients with refractory bipolar and depressive mood disorders.
The Dangers Associated with Female Adolescents Consuming Nyaope Drug in Butterworth, South Africa
Authors: Bala Samkelo , Kang’ethe Simon M. 
Published: June 2021

AbstractNyaope is a potent drug that is currently challenging South Africa; its ramifications have destroyed the country’s youth. The study described in this paper sought to explore the dangers associated with the consumption of Nyaope in Butterworth, South Africa. This study adopted an explorative and descriptive qualitative approach that involved the facilitation of focus group discussions and one-on-one interviews with twenty-six participants. An analysis of the findings of the study revealed the health hazards associated with consuming Nyaope and the tendency of Nyaope consumption to induce hallucinations and delusions in young people. Moreover, the study showed that Nyaope stimulated mood swings among female adolescents, its consumption created a fertile ground for conflict, and the addiction to Nyaope led to the destruction of the future of female adolescents. The researchers recommend the application of multiple approaches to preventing the initiation of Nyaope consumption. These approaches include attempts to control the peddling of Nyaope in schools and communities as well as the introduction of pro-active educational interventions regarding the dangers of Nyaope on the part of relevant institutions and government.
Theoretical and practical, but rarely integrated: Norwegian primary school teachers’ intentions and practices of teaching outside the classroom
Authors: Winje Øystein , Løndal Knut 
Published: June 2021

AbstractThis study investigates teachers’ intentions and practices related to teaching outside the classroom. We report on three months of fieldwork consisting of participatory observations and qualitative interviews of teachers in two Norwegian primary schools practising weekly uteskole [outdoor school]. We find that the teachers’ intentions for uteskole are to facilitate first-hand experiences for their pupils. The teachers organise and teach uteskole in two distinct ways: 1) friluftsliv activities [outdoor living activities] and 2) theoretical learning activities. The connections between friluftsliv activities and theoretical learning activities are seldom emphasised. Furthermore, the teachers rarely organise theoretical learning activities that entail pupils’ transacting with their surroundings. We discuss how the teachers’ work can be understood through the Romantic and the Pragmatist perspectives of experiential education and through the representational epistemology of traditional schooling. We outline how a transactional epistemology, operationalised as the “multi-modal model of knowing”, can support teachers in facilitating transaction between the pupils and the environment outdoors and aid in establishing continuity between learning activities outdoors and indoors. We argue that these are important factors that can enhance uteskole as a teaching method for facilitating deep learning in Norwegian primary education.
Remediation scenario of the abandoned Kettara mine site (Morocco): acid mine drainage (AMD) transport modeling
Authors: Lghoul Meriem , Sbihi Karim , Maqsoud Abdelkabir , Hakkou Rachid , Kchikach Azzouz 
Published: June 2021

AbstractIn this study, we present the efficiency of remediation scenario to attenuate the impact of acid mine drainage (AMD) contamination in the Kettara abandoned mine site. The study focuses on the AMD groundwater contamination of the Sarhlef shists aquifer. To predict the evolution of AMD groundwater contamination in the Kettara mine site under remediation scenario, a model of groundwater flow and AMD transport was performed.Piezometric heads were measured at the dry and wet periods from eleven wells located downstream of mine wastes. To elaborate a conceptual groundwater flow model, we faced with to the heterogeneity and anisotropy of fractured Sarhlef shists aquifer. Consequently, the study focused on the use of various approaches: 1. The inverse modeling by the CMA-ES algorithm is adopted as an alternative approach to determine hydraulic parameters indirectly, and 2. the model is treated as an equivalent porous media (EPM). The groundwater flow model was carried out in steady-state and transient conditions in the dry and wet periods using the PMWIN interface. The obtained results are satisfactory and show an excellent correlation between measured and computed heads. Contaminant transport model is used to solve the advection–dispersion equation and to generate the AMD concentration by MT3D via the PMWIN interface. A sensitivity analysis of the dispersivity coefficient is carried out. The AMD transport simulation was computed during periods of 1, 5 and 10 years, and the performed model indicates that the simulated concentrations under remediation scenario are reduced 1000 times comparing to the current concentrations. The study revealed a necessary approach in addressing an environmental issue for the AMD contamination. The results of the study will be a start-up for further research work in the study area and implementing it for the prevention of AMD propagation plume.
Elevated Anti-Müllerian Hormone Levels in Newborns of Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis Based on Observational Studies
Authors: Zhou Siyu , Lu Danhua , Wen Shu , Sheng Yongcheng , Kang Deying , Xu Liangzhi 
Published: June 2021

AbstractWe performed this updated systematic review and meta-analysis to evaluate anti-Müllerian hormone levels (AMH) in newborns of mothers with polycystic ovary syndrome (PCOS) compared with healthy controls. A search of the literature was conducted in the PubMed, MEDLINE, EMBASE, Cochrane Library, CBM, CNKI, WANFANG, and VIP for articles to assess AMH levels in offspring of PCOS and non-PCOS mothers irrespective of language. These databases were searched from their inception to December 7, 2020. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS) scoring system. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were adopted to calculate the overall estimates with random-effects models. A total of 6 studies with 846 participants were included. The pooled analysis found an increased AMH level in the umbilical cord blood in newborns of PCOS mothers (SMD =0.62, 95% CI [0.28, 0.95]). Subgroup analyses revealed an elevation of AMH concentrations in female neonates, neonates born to American and Asian PCOS mothers. In addition, higher AMH levels were also found in studies diagnosed by the National Institute of Health (NIH) criteria, maternal clinical/biochemical hyperandrogenism, or maternal body mass index (BMI) >30 kg/m2. Meta-regression analysis suggested that diagnostic criterion contributed mostly to the high heterogeneity. We demonstrated that AMH levels in neonates born to PCOS mothers were essentially higher, which indicates that AMH may act as an enigmatic role in the pathogenesis of PCOS which inhibits folliculogenesis in the fetal stage.
Moving-mass-based station keeping of stratospheric airships
Authors: Chen L. , Gao Q. , Deng Y. , Liu J. 
Published: June 2021

ABSTRACTStratospheric airships are lighter-than-air vehicles that work at an altitude of 20km in the lower calm portion of the stratosphere. They can be used as real-time surveillance platforms for environment monitoring and civil communication. Solar energy is the ideal power choice for long-endurance stratospheric airships. Attitude control is important for airships so that they can point at a target for observation or adjust the attitude to improve the output performance of solar panels. Stratospheric airships have a large volume and semi-flexible structure. The typical actuators used are aerodynamic surfaces, vectored thrust and ballonets. However, not all these actuators can work well under special working conditions, such as low density and low speed. In this study, moving-mass control is introduced to stratospheric airships because its control efficiency is independent of airspeed and atmospheric density. A nonlinear feedback controller based on generalised inverse with a nonlinear mapping module is designed to implement moving-mass control. Such a new station keeping scheme with moving masses is proposed for airships with different working situations.
On arithmetic progressions in non-periodic self-affine tilings
Authors: NAGAI YASUSHI , AKIYAMA SHIGEKI , LEE JEONG-YUP 
Published: June 2021

AbstractWe study the repetition of patches in self-affine tilings in
${\mathbb {R}}^d$
. In particular, we study the existence and non-existence of arithmetic progressions. We first show that an arithmetic condition of the expansion map for a self-affine tiling implies the non-existence of certain one-dimensional arithmetic progressions. Next, we show that the existence of full-rank infinite arithmetic progressions, pure discrete dynamical spectrum, and limit-periodicity are all equivalent for a certain class of self-affine tilings. We finish by giving a complete picture for the existence or non-existence of full-rank infinite arithmetic progressions in the self-similar tilings in
${\mathbb {R}}^d$
.
The effect of drone strikes on civilian communication: evidence from Yemen
Authors: Christia Fotini , Zoumpoulis Spyros I. , Freedman Michael , Yao Leon , Jadbabaie Ali 
Published: June 2021

AbstractAlthough covert warfare does not readily lend itself to scientific inquiry, new technologies are increasingly providing scholars with tools that enable such research. In this note, we examine the effects of drone strikes on patterns of communication in Yemen using big data and anomaly detection methods. The combination of these analytic tools allows us to not only quantify some of the effects of drone strikes, but also to compare them to other shocks. We find that on average drone strikes leave a footprint in their aftermath, spurring significant but localized spikes in communication. This suggests that drone strikes are not a purely surgical intervention, but rather have a disruptive impact on the local population.
Gender, Power, and Cricket Spectators in Calcutta, 1960s–1990s
Authors: Naha Souvik 
Published: June 2021

AbstractHistorians of modern India have emphasized the reflexivity of men and women in the making of womanhood, paying attention to notions of gender difference emerging from both primordial, restrictive codes of behaviour and contrarian impulses towards what was popularly called progress. There have been relatively few attempts to trace gender interaction in outdoor leisure activities, public displays of femininity, and male regulatory anxieties in the post-colonial context. By studying the symbolism of women's presence in the Eden Gardens, the international cricket stadium in Calcutta, from the 1960s to the 1990s, this article reflects on the nature of power, authority, and gender hierarchy in urban Indian society. This study of questions of gender hierarchy, women's mannerisms, social identity, and informal resistance through a historical lens will enable us to understand the trajectory of women's outsider status in urban public spaces. Through a reading of the mediated parti pris impressions of female spectators, it will also map the transition in society's approach to sport from a structured homosocial community activity to a relatively unstructured field of shared experience.
Bruce Smith and Anglo-Australian Liberalism
Authors: Paynter Alastair 
Published: June 2021

AbstractBruce Smith (1851–1937) was the most prominent Australian exponent of classical or ‘old’ liberalism in the late nineteenth and early twentieth century. Although his political career was not particularly successful, he was notable as the foremost defender of individualism as the authentic liberal creed, exemplified by his 1887 work Liberty and liberalism. He consistently attacked new liberalism, with its acceptance of extensive state interference, and socialism, as inimical to individual liberty and national prosperity. Although he is now recognized as an important figure in the Australian liberal pantheon, there has been relatively little attention to his thought outside Australia itself, despite his extensive connections to Britain. The general trajectory of Australian liberalism from ‘individualism’ to ‘collectivism’ was mirrored in Britain from the 1880s, especially during Prime Minister William Gladstone's second and third administrations, when the radicals within the Liberal party grew in influence and the aristocratic whig moderates waned. Smith maintained close links with the British Liberty and Property Defence League, which dedicated itself to fighting against collectivism, as well as with his personal hero, the philosopher Herbert Spencer, from whom his own politics derived much influence. This article considers Smith's thought through the prism of Anglo-Australian politics.
Political Professors and the Perception of Bias in the College Classroom
Authors: Liebertz Scott , Giersch Jason 
Published: June 2021

ABSTRACTThis article addresses three related questions. Does voicing a political ideology in class make a professor less appealing to students? Does voicing an ideology in class make a professor less appealing to students with opposing views? Does the intensity of professors’ ideology affect their appeal? We conducted survey experiments in two public national universities to provide evidence of the extent to which students may tolerate or even prefer that professors share their political views and under which conditions these preferences may vary. Results from the experiments indicate that expressing a political opinion did not make a professor less appealing to students—and, in fact, made the professor more appealing to some students—but the perception that a professor’s ideology is particularly intense makes the class much less favorable for students with opposing views. Students are indifferent between moderately political and nonpolitical professors.