bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corn Starch Reactive Blending with Latex from Natural Rubber in Presence of Na+ Ions of Carboxymethyl Cellulose as a Catalyst
Authors: Leksawasdi Noppol , Chaiyaso Thanongsak , Rachtanapun Pornchai , Jantrawut Pensak , Ruksiriwanich Warintorn , Seesuriyachan Phisit , Phimolsiripol Yuthana , Techapun Charin , Sommano Sarana Rose , Ougizawa Toshiaki , Jantanasakulwong Kittisak 
Published: July 2021

Abstract
Corn starch (CS) was blended with glycerol, latex natural rubber (LNR), and carboxymethyl cellulose (CMC). The addition of 10 phr of CMC improved the Young’s modulus (6.7 MPa), tensile strength (8 MPa), and elongation at break (80%) of the CSG/LNR blend. The morphology of the CSG/LNR/CMC blends showed a uniform distribution of LNR particles (1–3 µm) in the CSG matrix. The addition of CMC enhanced the swelling ability and water droplet contact angle of the blends owing to the swelling properties, interfacial crosslinking, and amphiphilic structure of CMC. Fourier transform infrared spectroscopy confirmed the reaction between the C=C bond of LNR and the carboxyl groups (–COO-) of CMC, in which Na+ ions in CMC acted as a catalyst. Notably, the mechanical properties of the CSG/LNR/CMC blend were improved owing to the miscibility of CSG/CMC and the CMC/LNR interfacial reaction.
The essential role of nuclear translocation of β-catenin in the osteoblastic differentiation of giant cell tumor of bone: Prediction of tumor ossification after denosumab treatment
Authors: Kimura Atsushi , Toda Yu , Matsumoto Yoshihiro , Yamamoto Hidetaka , Yahiro Kenichiro , Shimada Eijiro , Kanahori Masaya , Fukushima Suguru , Nakagawa Makoto , Setsu Nokitaka , Endo Makoto , Fujiwara Toshifumi , Matsunobu Tomoya , Oda Yoshinao , Nakashima Yasuharu 
Published: July 2021

Abstract
BackgroundDenosumab is a game-changing drug for giant cell tumor of bone (GCTB); however, its clinical biomarker in terms of post-administration ossification of the tumors has not been elucidated. The aims of this study were to investigate the relationship between Wnt/β-catenin signaling and the ossification of GCTB and to evaluate whether endogenous nuclear β-catenin expression predicted denosumab-induced bone formation in GCTB. MethodsWe established cultures of patient-derived primary GCTB stromal cells (pGCTB-SCs) and assessed the osteoblastic characteristics of pGCTB-SCs using cytochemical staining, optical density method (405 nm), and immunocytochemistry. Several mRNA expressions of osteoblastic markers (ALP, collagen type Ⅰ alpha 1 (COL1A1), integrin-binding sialoprotein (IBSP), runt-related transcription factor2 (RUNX2), and bone gamma-carboxyglutamate protein (BGLAP) was also investigated using quantitative real-time PCR (qRT-PCR) analysis. The impact on nuclear β-catenin translocation (NBT) by differentiation-induction was evaluated using Western blotting and immunocytochemistry. Wnt signaling inhibitor, GGTI-286, and selective Rac1 inhibitor, NSC23766, were added with OGM to evaluate the essential role of NBT. Furthermore, the distribution of endogenous NBT and the relationship with the tumoral ossification were assessed. Its predictability for the ossification in GCTB was also evaluated using a nuclear β-catenin labeling index (NBLI) of clinical samples (n = 86) and quantitative analyses of CT images.ResultspGCTB-SCs significantly expressed the osteoblastic markers with osteogenic medium (OGM) in a time-dependent manner (P < 0.0001, vs. vehicle). NBT was upregulated within 12 hours after OGM treatment. In addition, decreasing NBT by treatment with 40μM GGTI-286 significantly abolished the osteoblastic differentiation of pGCTB-SCs (P < 0.0001, vs. OGM). The selective Rac1 inhibitor, NSC23766, also suppressed the OGM-induced osteoblastic differentiation and NBT in pGCTB-SCs. Furthermore, in GCTB clinical samples, the NBTs were significantly associated with the tumor ossification following denosumab treatment (P = 0.003 for entire and peripheral tumor, and P = 0.02 for intra-tumor of GCTB) as well as endogenous intra-tumoral ossification. ConclusionsIn summary, our findings suggest a close relationship between the NBT and the osteoblastic differentiation of GCTB. Investigations of NBTs in naïve GCTB samples will provide a promising biomarker for predicting the ossification of GCTB following denosumab treatment.
Design and Analysis of a Novel Schönflies Motion Parallel Robot with Full Cycle Rotation
Authors: Li Luquan , Fang Yuefa , Wang Lin , Yao Jiaqiang 
Published: July 2021

Abstract

Due to the complex structures of multi-limbed parallel robots, conventional parallel robots generally have limited workspace, complex kinematics, and complex dynamics, which increases the application difficulty of parallel robot in industrial engineering. To solve the above problems, this paper proposes a single-loop Schönflies motion parallel robot with full cycle rotation, the robot can generate Schönflies motion by the most simplified structure. The novel Schönflies motion parallel robot is a two-limb parallel mechanism with least links and joints, and each limb is driven by a 2-degree of freedom (DOF) cylindrical driver (C-driver). The full cycle rotation of the output link is achieved by “…R-H…” structure, where the revolute (R) and helical (H) joints are coaxial. Mobility, kinematics, workspace and singularity analysis of novel Schönflies motion parallel robot are analyzed. Then, dynamic model is formulated based on the principle of virtual work. Moreover, a pick-and-place task is implemented by proposed Schönflies motion parallel robot and a serial SCARA robot, respectively. The simulation results verify the correctness of the theoretical model. Furthermore, dynamics performances of Schönflies motion parallel robot and serial SCARA robot are compared, which reveal the performance merits of proposed Schönflies motion parallel robot.
Liver Transplantation in Children and Impact of Intra-operative Goal Directed Therapies on Postoperative Outcome
Authors: Kumba Claudine 
Published: July 2021

Abstract
Background: Liver transplantation is a hemorrhagic surgery with high postoperative complication rates in terms of organ dysfunction and infections. We conducted a retrospective observational monocentric study that had the objectives of determining predictors of postoperative outcome in children. In the initial cohort, 19 children underwent liver transplantation. A description of the postoperative outcomes of these patients was undertaken.Objective: To describe intraoperative and postoperative outcomes in children undergoing liver transplantation and to propose intraoperative management implementation measures for postoperative outcome improvement.Methods: Secondary analysis of liver transplanted patients included in the initial study.Results: There were 19 patients who underwent liver transplantation with a median age of 31[2-154] months. Five patients had re-operations (26.3%). Fourteen (73.7%) had intraoperative and/or postoperative complications. Five (26.3%) had intraoperative hemorrhagic shock. One (5.3%) had postoperative respiratory failure, one (5.3%) had postoperative multiple organ failure, two (10.5%) had postoperative neurologic failure and five (26.3%) had cardio-circulatory failure. One (5.3%) had postoperative pulmonary sepsis, five (26.3%) had postoperative abdominal sepsis, and six (31.6%) had postoperative septicemia. Intra-operative transfusion rate was 100%. In-hospital mortality rate was 10.5% (two patients).Conclusion:There were multiple postoperative adverse outcome predictors. Optimal intraoperative patient management with transfusion guided by point-of-care viscoelastic devices and goal-directed fluid and hemodynamic therapy with validated parameters and tools in children is a possible pathway to upgrade postoperative evolution in pediatric liver transplantation.
Differences in affect integration in children with and without internalizing difficulties
Authors: Fiskum Charlotte , Andersen Tonje Grønning , Johns Unni Tanum , Jacobsen Karl 
Published: July 2021

Abstract

Background:
Affect represents an important source of information about our internal state and the external world that can motivate and vitalize us. When affect is poorly integrated, this can lead to problems with self-regulation and psychopathology. Few studies have investigated affect integration in children.

Objective:
This study investigates differences in affect integration in children with and without internalizing difficulties.

Method:
Thirty-three Norwegian children (aged 9–13) with and 24 children without internalizing difficulties were interviewed with the Affect Consciousness Interview (ACI), a measure of affect integration. Data from the ACI was analyzed across nine affective categories (Interest/Excitement, Enjoyment/Joy, Fear/Panic, Anger/Rage, Shame/Humiliation, Sadness/Despair, Envy/Jealousy, Guilt/Remorse, and Tenderness/Care), and four dimensions (Awareness, Tolerance, Emotional, and Conceptual expressivity).

Results:
The children differed significantly in affect integration across all dimensions and all assessed affects, both positive and negative. Emotional Expressivity, Anger/Rage, and Sadness/Despair were particularly less integrated in the children with internalizing problems.

Conclusions:
Assessment of affect integration can provide useful information on possible underlying factors in internalizing problems in children and may help guide and personalize therapeutic interventions. Based on knowledge from empirical infant psychology interventions mimicking rich, early intersubjective experiences are recommended to increase affect integration.
Advanced hybrid electro-oxidation & O3 technology for water reuse in the fruit and vegetable process industry
Authors: Sanchis Sonia , Gali David , Sala Vicent , Gomez Pedro , Pinedo Javier , Donato Javier , Berlanga Jose Guillermo , Garcia-Montaño Julia 
Published: July 2021

Abstract
Alternative sanitising agents are required in the fruit and vegetable processing industry, capable of effectively disinfecting both the product and the washing water to increase its reuse, while not producing harmful by-products like chlorine-based agents. In the present work, electro-oxidation (EO) and ozone are proposed for vegetable process water reuse, being optimised for their individual and combined application. The application of hybrid electro-oxidation and ozone achieved 7 log reduction after 15 min of treatment in batch using boron-doped diamond (BDD) as anode material, showing important synergistic effects when compared with the individual treatments. When the process was applied in continuous mode, up to 6 log reduction of total bacteria was achieved using EO alone with Ru as the anode and stainless steel as the cathode, under 11 mA/cm2 of current density, a cell retention time of 12 s and no addition of chemical reagents (electrolyte). Under these conditions, the absence of microorganisms in water was maintained for more than 24 h, no harmful by-products (chlorate, bromate) were detected and no damage to lettuce seeds were observed when evaluating water reuse potential.
Using Postmarket Surveillance to Assess Safety-Related Events in a Digital Rehabilitation App (Kaia App): Observational Study
Authors: Jain Deeptee , Norman Kevin , Werner Zachary , Makovoz Bar , Baker Turner , Huber Stephan 
Published: July 2021

Background
Low back pain (LBP) affects nearly 4 out of 5 individuals during their lifetime and is the leading cause of disability globally. Digital therapeutics are emerging as effective treatment options for individuals experiencing LBP. Despite the growth of evidence demonstrating the benefits of these therapeutics in reducing LBP and improving functional outcomes, little data has been systematically collected on their safety profiles.

Objective
This study aims to evaluate the safety profile of a multidisciplinary digital therapeutic for LBP, the Kaia App, by performing a comprehensive assessment of reported adverse events (AEs) by users as captured by a standardized process for postmarket surveillance.

Methods
All users of a multidisciplinary digital app that includes physiotherapy, mindfulness techniques, and education for LBP (Kaia App) from 2018 to 2019 were included. Relevant messages sent by users via the app were collected according to a standard operating procedure regulating postmarket surveillance of the device. These messages were then analyzed to determine if they described an adverse event (AE). Messages describing an AE were then categorized based on the type of AE, its seriousness, and its relatedness to the app, and they were described by numerical counts. User demographics, including age and gender, and data on app use were collected and evaluated to determine if they were risk factors for increased AE reporting.

Results
Of the 138,337 active users of the Kaia App, 125 (0.09%) reported at least one AE. Users reported 0.00014 AEs per active day on the app. The most common nonserious AE reported was increased pain. Other nonserious AEs reported included muscle issues, unpleasant sensations, headache, dizziness, and sleep disturbances. One serious AE, a surgery, was reported. Details of the event and its connection to the intervention were not obtainable, as the user did not provide more information when asked to do so; therefore, it was considered to be possibly related to the intervention. There was no relationship between gender and AE reporting (P>.99). Users aged 25 to 34 years had reduced odds (odds ratio [OR] 0.31, 95% CI 0.08-0.95; P=.03) of reporting AEs, while users aged 55 to 65 years (OR 2.53, 95% CI 1.36-4.84, P=.002) and ≥75 years (OR 4.36, 95% CI 1.07-13.26; P=.02) had increased odds. AEs were most frequently reported by users who had 0 to 99 active days on the app, and less frequently reported by users with more active days on the app.

Conclusions
This study on the Kaia App provides the first comprehensive assessment of reported AEs associated with real-world use of digital therapeutics for lower back pain. The overall rate of reported AEs was very low, but significant reporting bias is likely to be present. The AEs reported were generally consistent with those described for in-person therapies for LBP.
Combined Mutations of DMD and CFTR Genes in an Azerbaijani Family
Authors: Saltanat Aghayeva  , Lala Huseynova  , Hagverdiyeva  Raya  
Published: July 2021

A 9 year old boy with the obvious traits of Duchene muscular dystrophy disease is a resident of Masalli region of Azerbaijan, located in the south-east foothill of Talysh Mountains. Family members such as mother, father and sister of this index patient were examined. To diagnose all members of the family, biochemical analysis was conducted for quantitative analysis of creatine phosphokinase in blood serum and genealogical survey identified inherited disease cystic fibrosis in first cousin of this index patient . Quantitative evaluation of creatine phosphokinase in blood serum was performed for all family members of the index patient ., and identified high values: in index patient (2298 U/L, norm - 38-137 U/L), in his mother (879 U/L, norm - 26-140 U/L) and his sister (852U/L, norm - 26-140 U/L), whereas his father had normal range values of creatine phosphokinase in blood (53,1 U/L, where norm - 38-137 U/L). Diagnosis of Duchenne muscular dystrophy disease was confirmed in index patient in hemizygous state. His mother and sister were found as heterozygous carriers of the (Duchenne muscular dystrophy) DMD gene. Molecular genetic analysis of the DMD gene (MLPA) identified mutation in the mother and sister of the index patient. Mutation type was nonsense, and classified as pathogenic class. Molecular genetic analysis of the DMD gene showed a gain of mutations, consisting of two copies encompassing exon 03 to 09 in the index patient, mother and his sister. The identified two different mutations of DMD gene in Azerbaijani family: fragment deletion of exon 45 in three sibs from Astara region of Azerbaijan, located in the south-east of the country, and deletion encompassing exons from 8 to 20 in 10-year-old boy in Balakan region, located in the north-west of the Republic Mutation type is a nonsense mutation and classified as pathogenic of class 1. Inherited cystic fibrosis in heterozygous state was additionally identified in the index patient, in father and sister. The screening of identified mutations may serve as a prenatal diagnostic tool to carefully plan the prophylaxis in patients with cystic fibrosis. Furthermore, our studies may serve as a basis for the future investigation of many aberrant molecular mechanisms and regulatory pathways. The study of Duchenne and Becker muscular dystrophy resulted in one of the first successful attempts at reverse genetics, better described as positional cloning, in humans. Discovery and subsequent analysis of the gene mutation that results in the clinical disorder led to the discovery of the encoded protein, dystrophin. This coinage set a precedent for the naming of proteins discovered by positional cloning of human disease genes: for example, huntingtin, emerin, and ataxin
Tools for Developing a Regional Education Development Strategy
Authors: Lapygin Yu. N. , Boltunov S. A. 
Published: July 2021

The framework structure of the federal law on strategic planning leaves a wide field of activity for developers to use various tools in the process of building a development strategy for both the region and its sub-systems, which include the education system of the region. The methodological recommendations of the Ministry of Economic Development of the Russian Federation regarding the development of a strategy specify only the content of the main directions of the strategy, but allow the use of various methods, models and mechanisms for developing the strategy itself. Therefore, the study of the issues of instrumental support of procedures for developing strategies for regions and its subsystems is of interest from a theoretical and practical point of view.In the study of theoretical and applied problems of instrumental support of the process of developing a strategy, algorithms are built in the form of a general scheme for developing a strategy and performing a comprehensive analysis prior to development. Algorithms for developing a strategy at the initial stage were formed based on the results of a comprehensive analysis, at the stage focused on the main goal (Mission), as well as at the final stage, the goals of which are focused on the ideal state in the future — Vision. Besides. An algorithm for determining the expected results has been built. on the basis of which a scenario for the development of regional subsystems is built.The scientific novelty of the developed procedures lies in the fact that a set of tools for determining strategically significant projects and programs of the final and intermediate stages of strategy implementation is proposed; tools for agreeing strategically significant decisions were formed throughout the cycle of strategic development of the region’s education system; shows the procedure for constructing a tree of goals for the intermediate stage of the strategy implementation; a procedure for the formation of a development strategy at the intermediate stage of strategy implementation has been developed. The proposed approach to building a strategy for the development of socio-economic systems in the region is implemented in the process of adjusting the development strategy of the Vladimir region in terms of vocational education in the region.
Penambahan Tepung Kedelai Pada Roti Tawar Tepung Sorgum dan Pati Garut Bebas Gluten dengan Zat Besi dan Serat Pangan
Authors: Khoirunnisa Wilda , Fauziyah A’immatul , Nasrullah Nanang 
Published: July 2021

Kedelai merupakan biji-bijian dengan zat besi dan serat pangan sehingga dapat menaikkan kadar zat besi dan serat pangan pada produk bebas gluten untuk aman dikonsumsi oleh penderita penyakit celiac wanita dewasa. Penelitian ini bertujuan untuk menganalisis pengaruh penambahan tepung kedelai terhadap kadar zat besi dan serat pangan, mengetahui sifat organoleptik, memperoleh formula terpilih, dan mengetahui kandungan zat gizi per takaran saji formula terpilih. Penelitian ini menggunakan desain Rancangan Acak Lengkap (RAL). Analisis data kadar zat besi dan serat pangan menggunakan uji One Way ANOVA (analisis ragam) dan uji lanjut Duncan Multiple Range Test (DMRT). Analisis uji organoleptik diolah secara deskriptif. Pemilihan formula terpilih menggunakan Metode Perbandingan Eksponensial (MPE). Hasil uji anova menunjukkan bahwa penambahan tepung kedelai berpengaruh nyata (p = 0,028) terhadap kadar zat besi roti tawar dan tidak berpengaruh nyata (p = 0,545) terhadap kadar serat pangan roti tawar. Formula roti tawar yang terpilih berdasarkan kadar zat besi, serat pangan, dan uji organoleptik adalah F3 (50% tepung kedelai). Takaran saji roti tawar formula terpilih adalah 72 gram untuk 2 lembar dengan kandungan gizi sebesar 260,44 kkal energi total, 13,97 gr protein, 10,35 gr lemak, 27,83 gr karbohidrat, 3,33 mg zat besi, dan 34,22 gr serat pangan sehingga memenuhi klaim sebagai pangan dengan zat besi dan serat pangan.
Capaian Perkembangan Kognitif Anak Stunted dan Normal di TK/KB
Authors: Nirmala Besse 
Published: July 2021

Anak pendek atau stunting, merupakan kondisi gagal tumbuh pada anak yang terjadi sejak bayi dalam kandungan dan pada masa awal setelah bayi lahir. Akan tetapi, kondisi stunting baru nampak setelah bayi berusia dua tahun akibat dari kekurangan gizi kronis sehingga anak terlalu pendek untuk usianya. Kasus stunting ditemukan di Sulawesi Tengah khususnya di Kecamatan Palu Utara. Pendidikan Anak Usia Dini (PAUD) memiliki peran penting dalam berkontribusi mengantisipasi dan menurunkan tingkat stunting pada anak. Data kesehatan anak pada lembaga PAUD, khususnya tinggi badan, berat badan dan lingkar kepala anak, umumnya hanya dicatat tanpa dianalisis maupun dimanfaatkan untuk dimensi layanan kesehatan dan gizi dalam program Holistik Integratif (HI). Keterlibatan PAUD menghadapi fenomena stunting pada anak di Indonesia dapat dilakukan melalui penerapan PAUD berbasis HI secara maksimal. Penelitian ini bertujuan untuk mengetahui capaian perkembangan kognitif pada anak yang stunting dan normal. Kriteria stunting ditentukan berdasarkan indeks TB/U <-2 SD. Penelitian ini melibatkan 134 anak TK di Kecamatan Palu Utara. Analisis data dilakukan melalui analisis univariat untuk melihat distribusi frekuensi dan bivariat untuk melihat hubungan antar variabel. Hasil penelitian menunjukkan bahwa terdapat 13 orang anak (9,7%) mengalami stunting dan terdapat 121 orang anak (91,3%) dalam kategori normal. Dilihat dari pencapaian perkembangan kognitif anak stunting, 5,2% belum berkembang dan 5,7% mulai berkembang. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa ada hubungan antara kejadian stunting dengan capaian perkembangan kognitif anak usia dini.