bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of the First U.S. FDA-Approved Hip Resurfacing Device at 10-Year Follow-up
Authors: Su Edwin P. , Ho Henry , Bhal Vinay , Housman Lawrence R. , Masonis John L. , Noble John W. , Hopper Robert H. , Engh C. Anderson 
Published: May 2021

Background:
The BIRMINGHAM HIP Resurfacing (BHR) system is a metal-on-metal hip implant system approved by the U.S. Food and Drug Administration in 2006. The approval required a multicenter, prospective, post-market-approval study. Our purpose is to report the current results at 10 years of follow-up.

Methods:
Between October 2006 and December 2009, 280 primary BHR procedures were performed at 5 sites. Outcome measures included Kaplan-Meier survivorship, reasons for revision, radiographic component stability and osteolysis, Harris hip scores, and metal levels including cobalt and chromium. The mean age at the time of the procedure was 51.3 ± 7.1 years, 74% (206) of 280 BHRs were implanted in male patients, the mean body mass index was 27.8 ± 4.4 kg/m2, and 95% (265) of 280 hips had a primary diagnosis of osteoarthritis. The mean follow-up among all 280 hips was 9.0 ± 2.5 years. Prior to 10-year follow-up, 20 hips were revised and 5 patients representing 5 hips had died. Among the remaining 255 hips, 218 (85%) met the minimum follow-up of 10 years.

Results:
The 10-year survival free from all-cause component revision was 92.9% (95% confidence interval [CI], 89.8% to 96.1%) for all hips and 96.0% (95% CI, 93.1% to 98.9%) among male patients <65 years old at the time of the procedure. Reasons for revision included femoral loosening (n = 5), femoral neck fracture (n = 3), pseudotumor (n = 3), osteolysis (n = 2), and acetabular loosening (n = 1), as well as 6 revisions for a combination of pain, noise, or metal levels. Among unrevised hips, the median Harris hip score improved from preoperatively (59) to 1 year postoperatively (99; p < 0.001) and remained stable through 10 years postoperatively (99; p = 0.08). Radiographically, 5% (10) of 218 unrevised hips had osteolysis with no component migration. Median metal levels had increased at 1 year postoperatively (cobalt: from 0.12 ppb preoperatively to 1.5 ppb at 1 year postoperatively, p < 0.001; chromium: from 0.6 ppb preoperatively to 1.7 ppb at 1 year postoperatively, p < 0.001), then remained stable through 5 years before slightly decreasing at 10 years postoperatively (cobalt: 1.3 ppb, p < 0.001; chromium: 1.4 ppb, p < 0.001).

Conclusions:
This prospective, multicenter, post-market-approval study demonstrated that the BHR implant system is safe and effective through 10 years of follow-up, particularly among young male patients.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Simultaneous Total Knee Arthroplasty and Proximal Tibiofibular Joint Arthrodesis
Authors: Aebischer Andrea S. , Wing Nicholas , Wall Christopher J 
Published: May 2021

Case:
A 57-year-old man presented with tricompartmental left knee osteoarthritis, as well as proximal tibiofibular joint arthritis and a ganglion cyst. He underwent simultaneous total knee arthroplasty and proximal tibiofibular joint arthrodesis, with an excellent outcome.

Conclusion:
Proximal tibiofibular joint arthritis is uncommon and may be associated with tibiofemoral arthritis, proximal tibiofibular joint instability, and ankylosing spondylitis. We present a case of simultaneous total knee arthroplasty and proximal tibiofibular arthrodesis. This is an effective option for treating patients with dual pathology. The proximal tibiofibular joint should be considered as an uncommon cause of lateral knee pain.
Incidental Bilateral Scaphotrapezial Coalition in a High-Level Throwing Athlete
Authors: Wininger Austin E. , Jafarnia Kourosh K. 
Published: May 2021

Case:
Scaphotrapezial coalition is a rare carpal coalition and historically associated with congenital syndromes because it spans 2 carpal rows. We present the case of an 18-year-old collegiate baseball pitcher who was incidentally found to have bilateral scaphotrapezial coalition. He had no history of wrist pain and no functional limitations on physical examination. He had no family history of this condition and no personal history of congenital abnormalities.

Conclusions:
Bilateral scaphotrapezial coalition can be an incidental and asymptomatic finding that is present even in high-level throwing athletes.
Optimal Drawdown for Woodford and Mayes in the Anadarko Basin Using Data Analytics
Authors: Alzahabi Ahmed , Alexandre Trindade A. Alexandre , Kamel Ahmed A. , Harouaka Abdallah , Baustian Wade , Campbell Catherine 
Published: May 2021

Summary
One of the enduring pieces of the jigsaw puzzle for all unconventional plays is drawdown (DD), a technique for attaining optimal return on investment. Assessment of the DD from producing wells in unconventional resources poses unique challenges to operators; among them the fact that many operators are reluctant to reveal the production, pressure, and completion data required. In addition to multiple factors, various completion and spacing parameters add to the complexity of the problem. This work aims to determine the optimum DD strategy. Several DD trials were implemented within the Anadarko Basin in combination with various completion strategies. Privately obtained production and completion data were analyzed and combined with well log analysis in conjunction with data analytics tools. A case study is presented that explores a new strategy for DD producing wells within the Anadarko Basin to optimize a return on investment. We use scatter-plot smoothing to develop a predictive relationship between DD and two dependent variables—estimated ultimate recovery (EUR) and initial production (IP) for 180 days of oil—and introduce a model that evaluates horizontal well production variables based on DD. Key data were estimated using reservoir and production variables. The data analytics suggested the optimal DD value of 53 psi/D for different reservoirs within the Anadarko Basin. This result may give professionals additional insight into more fully understanding the Anadarko Basin. Through these optimal ranges, we hope to gain a more complete understanding of the best way to DD wells when they are drilled simultaneously. Our discoveries and workflow within the Woodford and Mayes Formations may be applied to various plays and formations across the unconventional play spectrum. Optimal DD techniques in unconventional reservoirs could add billions of dollars in revenue to a company’s portfolio and dramatically increase the rate of return, as well as offer a new understanding of the respective producing reservoirs.
Genetic Algorithm based Predictive model for COVID 19 – Theoretical Model based on an evolutionary approach
Authors: Rangarajan Srikanth , Poranki Srikanth , Sammakia Bahgat 
Published: May 2021

Abstract
In this manuscript we propose a novel theoretical method that models the evolution, spread and transmission of COVID 19 pandemic. The proposed model is inspired partly from the evolutionary based state of the art genetic algorithm. The rate of virus evolution, spread and transmission of the COVID 19 and its associated recovery and death rate are modeled using the principle inspired from evolutionary algorithm. Furthermore, the interaction within a community and interaction outside the community is modeled. The constraint with respect to interaction has been implemented by a machine learning type algorithm and becomes the unique part of our study . Using this model, the maximum healthcare threshold is fixed as a constraint. Our evolutionary based model distinguishes between individuals in the population depending on the severity of their symptoms/infection based on the fitness value of the individuals. There is a need to differentiate between virus infected diagnosed (Self isolated) and virus infected non-diagnosed (Highly interacting) sub populations/group. In this study the model results does not compare the number outcomes with any actual real time data based curves. However, the results from the model demonstrates that a strict lockdown, social-distancing measures in conjunction with more number of testing and contact tracing is required to flatten the ongoing COVID-19 pandemic curve. A reproductive number of 2.4 during the initial spread of virus is predicted from the model for the randomly considered population. The proposed model has the potential to be further fine-tuned and matched accurately against real time data.
Prognostic Value of Onodera’s Nutritional Index for Intermediate and High Risk Gastrointestinal Stromal Tumors Treated With or Without Tyrosine Kinase Inhibitors
Authors: wang feng , Tao Tingting , Yu Heng , Xu Yingying , Yang Zhi , Xia Xuefeng , Wang Meng , Zong Liang , Guan Wenxian 
Published: May 2021

Abstract
Background: Immunoinflammatory and nutritional markers such as peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and onodera’s prognostic nutritional index (OPNI) have gained considerable attention and revealed preliminaryly as prognostic markers in gastrointestinal stromal tumor (GIST).Methods: In this study, we firstly investigated the prognostic value of OPNI in GIST treated with or without TKIs based on the propensity score matching (PSM) method. All of the patients had received surgical resection for primary GIST, the data from 2010 to 2018 were initially and retrospectively identified from our gastrointestinal center. Recurrence-free survival (RFS) was calculated by the Kaplan-Meier method and compared by the log-rank test.Results: These patients who were treated with TKIs and those who did not were divided into two groups, and we used propensity score matching method to make them have more unified baseline data. Multivariate Cox proportional hazard regression models were applied to identify associations with outcome variables. A total of 563 GISTs were initially chosen and 280 of them were included for analysis under an inclusion criteria. After PSM, there were 200 patients included. Multivariate analyses identified OPNI was an independent prognostic marker, and was associated with primary site, tumor size, mitotic index, tumor rupture, necrosis, and modified NIH risk classification. Low OPNI (<42.6; HR 0.409; P＜0.001) were associated with worse RFS.Conclusions: Preoperative OPNI is a novel and useful prognostic marker for GISTs both treated with or without TKIs. Higher NLR and PLR have negative effects for RFS.
Point-of-Care Ultrasound-Guided Conservative Fluid Therapy Improved the Outcome of Critically Ill Patients: A Before-and-After Study
Authors: He Hui , Zeng Mingqiang , Chen Jing , Deng Lei , Chen Youdai 
Published: May 2021

Abstract
ObjectivesTo study the impact of fluid balance on the outcome of critically ill patients.MethodsCritically ill patients managed with point-of-care ultrasound were compared with those managed without. Distended internal jugular veins and inferior vena cava with reduced collapsibility were taken as signs of hypervolemia.ResultsCompared with critically ill patients admitted before application of point-of-care ultrasound assessment (from March, 2019 through October, 2019; 291 cases), cases admitted after (from November, 2019 through June, 2020; 285 cases) had significantly lower in-ICU mortality (34.7% vs 26.7%, p=0.038; Fisher’s exact test), together with a dramatic change from overall positive fluid balance to negative one (for cumulative fluid balance during ICU stay, 2820±1381ml vs -10±39ml; p=0.001). Multiple logistic regression showed that cumulative fluid balance during ICU stay, Acute Physiology and Chronic Health Evaluation (APACHE) II score and Sequential Organ Failure Assessment (SOFA) score on admission were independent risk factors for in-ICU mortality (p<0.001, p<0.001 and p=0.043 respectively). After controlling for disease severity, Cox hazard ratio of cases with a negative cumulative fluid balance during ICU stay was 0.683 (95% confidence interval 0.475-0.981; p=0039).ConclusionsNegative cumulative fluid balance during ICU stay was associated with a reduced in-ICU mortality.
Comparison of photoscreeners and hand-held autorefractometer with cycloplegic autorefraction as a vision screening tool for children with newly diagnosed attention deficit hyperactivity disorder
Authors: Yalinbas Duygu , Kara Caner , Sari Seda Aybuke , Dursun Demet , Bozali Erman 
Published: May 2021

Abstract
Purpose: To compare non-cycloplegic refraction measurements of two photoscreeners and the hand-held autorefractometer with cycloplegic measurements of the autorefractometer in patients with attention deficit hyperactivity disorder (ADHD).Methods: This cross-sectional, comparative study consisted of 53 children who were newly diagnosed with ADHD. We compared spherical, cylindrical, cylindrical axis and spherical equivalent (SE) measurements in Plusoptix A12, Spot Vision Screener, and Retinomax K-plus Screen with Tonoref II. Reliability was analyzed by using the interclass correlation coefficient (ICC) and Bland-Altman plot was used to evaluate the agreement between devices.Results: The mean age of children was 9.45 ± 1.68. All of the devices measured spherical power and SE significantly more myopic than the Tonoref II. While The Spot Vision Screener, PlusoptiX A12, and Tonoref II provided similar cylindrical power, Retinomax K-plus Screen measured significantly lower than the Tonoref II. The excellent reliability was detected in spherical power, cylindrical power, SE and J0 between Tonoref II and PlusoptiX A12 (ICC:0.930, 0.921, 0.927 and 0.920, respectively. All of the hand-held devices showed excellent reliability in terms of cylindrical power and J0 (ICC>0.90, for all) and good reliability for J45 (ICC:0.75-0.90 for all).Conclusion: Despite all devices having advantages or disadvantages, Plusoptix A12 showed excellent reliability for detecting refractive errors in children with ADHD.
Non-Invasive Rhythmic Musical-Electric Trigeminal Nerve Stimulation Improves Consciousness in Patients with Disorders of Consciousness
Authors: Wu Min , Luo Benyan , Yu Yamei , Li Xiaoxia , Gao Jian , Li Jingqi , Sorger Bettina , Riecke Lars 
Published: May 2021

Abstract
Disorders of consciousness (DOC) are often accompanied by aberrant oscillatory neural activity in the thalamus and cerebral cortex. Patient-friendly non-invasive treatments targeting this functional anomaly are still missing. We propose and validate a novel approach that aims to restore DOC patients’ thalamocortical oscillations by combining rhythmic trigeminal-nerve stimulation (TNS) with comodulated musical stimulation. In a cluster-randomized, placebo-controlled, double-blinded, pretest-posttest clinical study, we show that application of this multisensory approach for 40 min on five consecutive days reliably leads to long-lasting improvements in DOC patients’ consciousness (assessed with Coma Recovery Scale-Revised) and oscillatory brain activity at the musical-electric TNS frequency (assessed with electroencephalography and a novel rhythmic auditory-speech paradigm). We found diagnostic improvement in 47% of patients in minimally conscious state and a positive relationship between patients’ behavioral and neural improvements. Based on this evidence we argue that non-invasive musical-electric TNS may serve as an effective patient-friendly DOC treatment and suggest frequency-specific oscillatory neural enhancement as its mode of action.
Celastrol Attenuates the Remodeling of Pulmonary Vascular and Right Ventricular in Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats
Authors: Li Huayang , Liu Quan , Yue Yuan , Wang Shunjun , Huang Suiqing , Huang Lin , Li Luo , Zhang Yitao , Wu Zhongkai 
Published: May 2021

Abstract
Background: Pulmonary arterial hypertension (PAH) is a progressive angio-proliferative disease associated with high morbidity and mortality rates. Although the histopathology of PAH is well described, its therapeutic option remains unsatisfactory. This study investigated the effect of celastrol treatment on PAH right ventricular (RV) dysfunction, RV remodeling and pulmonary vascular remodeling in rats as well as its possible mechanisms.Methods: PAH was induced in rats by a single subcutaneously injection of monocrotaline (MCT). After daily delivery of celastrol (1 mg/kg) or vehicle via intraperitoneal injection for 4 weeks, the effects of celastrol on RV function, fibrosis, and pulmonary vascular remodeling were assessed. The infiltration of macrophages, the expression of inflammatory cytokines, including MCP-1, IL-1β, IL-6, and IL-10, and the expression of NF-κB signaling pathway-associated proteins, IkBα, p-IKKα/β and p65 were further detected. Finally, the effect of celastrol on human pulmonary artery smooth cells (HPASMCs) proliferation under hypoxia was studied in vitro.Results: Rats with PAH had decreased RV function, increased RV fibrosis and pulmonary arteries with interstitial thickening and prominent media hypertrophy. Treatment with celastrol improved RV function, and attenuated RV fibrosis and pulmonary vascular remodeling. Significantly decreased macrophage infiltration, reduced levels of pro-inflammatory cytokines, increased level of anti-inflammatory cytokine and inhibited NF-κB signaling pathway were observed in the lung tissues of rats treated with celastrol. Moreover, celastrol significantly suppressed the proliferation of HPASMCs under hypoxia.Conclusions: We showed that in rats with PAH, celastrol could improve RV function, and attenuate RV and pulmonary vascular remodeling and HPASMCs proliferation under hypoxia. Suppression of the NF-κB signaling pathway may be a part of the protective mechanism.
Demographic Profile of Patients and Geospatial Mapping in Palliative Care: A Hospital Based Study from Eastern Part of India
Authors: Rani Rita , Singh Usha , Trivedi Vinita , Chauhan Richa , Mishra Mukul , Sinha Rajani 
Published: May 2021

Abstract
Background

With the rising burden of cancer in India, there is a huge need to start and expand Palliative care (PC) services in different parts of the country. understanding the demographic profile of the Palliative care patients will help in customising the PC services. Aim of the study was to look into demographic details of the patients and to do Geospatial mapping of the patients referred for PC.
Methods

Data was extracted from patient’s case records referred to PC OPD was put into Excel sheet analysed statistically along with Geospatial mapping.
Results

Among a total of 1084 patients, 54.9% were men and about 24.2% were women. Maximum number of patients were in 4th decade of their life, relatively younger population. About 57% were poor and 47.1% were illiterate. About 37.2% were head and neck cancer patients with pain as the most commonly reported symptom among all patients. Bony metastasis was most common and majority of the patients belonged to Patna District of Bihar.
Conclusions

This study of demographic patterns of patient and geospatial mapping will help in sensitising towards PC and establishing better PC services and policy making in different parts of the country.
A New Ball Detection Strategy for Enhancing the Performance of Ball Bees Based on Fuzzy Inference Engine
Authors: Abulwafa Arwa , Saleh Ahmed I. , Saraya Mohamed S. , Ali Hesham A. 
Published: May 2021

Abstract
Sports video analysis has received much attention as it is turned to be a hot research area in the field of image processing. This led to opportunities to develop fascinating applications supported by analysis of different sports especially football. Identifying the ball in soccer images is an essential task for not only goal scoring but also players’ evaluation. However, soccer ball detection suffers from several hurdles such as; occlusions, fast moving objects, shadows, poor lighting, color contrast, and other static background objects. Although several ball detection techniques have been introduced such as; Frame Difference, Mixture of Gaussian (MoG), Optical Flow and etc., ball detection in soccer games is still an open research area. In this paper, a new Fuzzy Based Ball Detection (FB2D) strategy is proposed for identifying the ball through a set of image sequences extracted form a soccer match video. FB2D has the ability to accurately identify the ball even if it is attached to the white lines drawn on the playground or partially occluded behind players. FB2D has been compared to recent ball detection techniques. Experimental results have shown that FB2D outperforms recent detection techniques as it introduced the maximum accuracy and the accuracy of detection in the testing stage is close to 100%. As well as the minimum error.
Bovine host genome acts on specific metabolism, communication and genetic processes of rumen microbes host-genomically linked to methane emissions
Authors: Martínez-Álvaro Marina , Auffret Marc , Duthie Carol-Anne , Dewhurst Richard , Cleveland Matthew , Watson Mick , Roehe Rainer 
Published: May 2021

Abstract
Whereas recent studies in different species showed that the host genome shapes the microbial community profile, our new research strategy revealed substantial host genomic control of comprehensive functional microbial processes in the rumen of bovines by utilising microbial gene profiles from whole metagenomic sequencing. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified, 203/16/352 were significantly (P<2.02 x10-5) heritable (0.13 to 0.61), revealing substantial variation in host genomic control. We found 29/22/115 microbial genera/RUGs/genes host-genomically correlated (-0.93 to 0.92) with emissions of the potent greenhouse gas methane (CH4), highlighting the strength of host genomic control of specific microbial processes impacting on CH4. Only one of these microbial genes was directly involved in methanogenesis (cofG), whereas others were involved in providing substrates for archaea (e.g. bcd and pccB), important microbial interspecies communication mechanisms (ABC.PE.P), host-microbiome interaction (TSTA3) and genetic information processes (RP-L35). In our population, selection based on abundances of the 30 most informative microbial genes provided a mitigation potential of 17% of mean CH4 emissions per generation, which is higher than for selection based on measured CH4 using respiration chambers (13%), indicating the high potential of microbiome-driven breeding to cumulatively reduce CH4 emissions and mitigate climate change.