bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing a global quality of care benchmark report
Authors: Sampurno Fanny , Cally Justin , Opie Jacinta L , Kannan Ashwini , Millar Jeremy L , Finelli Antonio , Vickers Andrew J , Moore Caroline M , Kowalski Christoph , Foster Claire , Barocas Dan A , Galvin David , Van Basten Jean-Paul , Gore John L , Ferencz Julia , Lawson Keith A , Ghani Khurshid R , Kwan Lorna , Saarela Olli , Connor Sarah E , Dieng Sebastian , Linsell Susan , Soeterik Timo FW , Villanti Paul , Litwin Mark S , Evans Sue M 
Published: June 2021

Background: The Movember funded TrueNTH Global Registry (TNGR) aims to improve care by collecting and analysing a consistent dataset to identify variation in disease management, benchmark care delivery in accordance with best practice guidelines and provide this information to those in a position to enact change. We discuss considerations of designing and implementing a quality of care report for TNGR. Methods: Eleven working group sessions were held prior to and as reports were being built with representation from clinicians, data managers and investigators contributing to TNGR. The aim of the meetings was to understand current data display approaches, share literature review findings and ideas for innovative approaches. Preferred displays were evaluated with two surveys (survey 1: 5 clinicians and 5 non-clinicians, 83% response rate; survey 2: 17 clinicians and 18 non-clinicians, 93% response rate). Results: Consensus on dashboard design and three data-display preferences were achieved. The dashboard comprised two performance summary charts; one summarising site’s relative quality indicator (QI) performance and another to summarise data quality. Binary outcome QIs were presented as funnel plots. Patient-reported outcome measures of function score and the extent to which men were bothered by their symptoms were presented in bubble plots. Time series graphs were seen as providing important information to supplement funnel and bubble plots. R Markdown was selected as the software program principally because of its excellent analytic and graph display capacity, open source licensing model and the large global community sharing program code enhancements. Conclusions: International collaboration in creating and maintaining clinical quality registries has allowed benchmarking of process and outcome measures on a large scale. A registry report system was developed with stakeholder engagement to produce dynamic reports that provide user-specific feedback to 132 participating sites across 13 countries.
Nutritional social work: What it is and why it matters
Authors: Dylan Arielle , Cammaert Jenni 
Published: June 2021

Summary This article introduces the area of nutritional social work, beyond the scope of food security and food injustice, from a critical, anti-oppressive and ecofeminist lens. The goal was not to present concrete frameworks but to initiate a discussion surrounding the relevance of nutritional social work and point in a number of possible directions for incorporation of this subdiscipline into social work praxis. Findings Nutritional security is an instrumental component of food security, as complete nutrition requires more than just enough energy for every human being. This purposeful combining of food security with nutrition security underscores the need to consider these two issues together, requiring integrated social and health outcomes, as well as cohesive community, policy and development goals aimed at eliminating food insecurity and malnutrition. These considerations need to involve the questions of availability, accessibility (both economically and geographically), cultural practices and sustainability that form the cornerstone of food justice efforts. Applications The article highlights the potential contribution of nutritional social work to direct practice, community action, policy development, research and social work education, as it illuminates the pivotal role that nutritional security plays in relation to multilevel considerations of food insecurity, all the while ensuring all people, through participatory, democratizing, power-sharing and equity-creating processes, have access to nutritious foods.
Critical realism, mimetic theory and social work
Authors: Houston Stan , Swords Calvin 
Published: June 2021

Summary Scapegoating is a ubiquitous, yet pernicious, phenomenon in today’s world. It manifests in innumerable ways. Social work, in line with its emancipatory value-base, seeks to engage with various scapegoated groups to challenge the experience. In this article, the authors draw on critical realism and mimetic theory to elucidate the causative mechanisms fuelling scapegoating. This is done in order to heighten social workers’ insight into the process and empower targeted groups. Findings Mimetic theory highlights that scapegoating is a product of desire, rivalry and deflection. These are deep-seated mechanisms that are compatible with critical realist ontology and its search for causative properties in the social world. It is argued that critical realism augments mimetic theory by setting it within a much wider and deeper context of understanding. As such, it emphasizes intersecting causes and contingencies such as the role of temporal and spatial factors shaping the scapegoating experience. Applications Social workers can transform these theoretical insights into sensitizing constructs when they facilitate self-directed groupwork with scapegoated groups. Being theoretically informed, they can pose critical questions to group members to assist them to make the link between personal problems and political issues. The aim is to empower these groups so that they can embrace the sociological imagination and act for change.
Voxel-based quantitative susceptibility mapping revealed increased cerebral iron over the whole brain in chronic migraine
Authors: Chen Zhiye , Dai Wei , Chen Xiaoyan , Liu Mengqi , Ma Lin , Yu Shengyuan 
Published: June 2021

Background The previous documents demonstrated that iron deposition was identified in brain deep nuclei and periaqueductal gray matter region in chronic migraine (CM), and less is known about the cerebral iron deposition in CM. The aim of this study is to investigate the cerebral iron deposition in CM using an advanced voxel-based quantitative susceptibility mapping. Methods A multi-echo gradient echo MR sequence was obtained from 14 CM patients and 28 normal controls (NC), and quantitative susceptibility mapping images were reconstructed and voxel-based analysis was performed over the whole cerebrum. The susceptibility value of all the positive brain regions was extracted and correlation was calculated between the susceptibility value and the clinical variables. Results The brain regions with increased susceptibility value in CM patients located in right precuneus, insula, supramarginal gyrus, dorsolateral superior frontal gyrus, postcentral gyrus, cuneus and left postcentral gyrus compared with NC. The correlation analysis demonstrated that a positive correlation was identified between susceptibility value of all the positive brain regions and VAS score. Conclusion The current study demonstrated increased cerebral iron deposition presented in chronic patients, which suggested that increased cerebral iron deposition might play a role in the migraine chronicization.
Vitamin D in Basketball Players: Current Evidence and Future Directions
Authors: Stojanović Emilija , Radovanović Dragan , Hew-Butler Tamara , Hamar Dušan , Jakovljević Vladimir 
Published: June 2021

Context: Despite growing interest in quantifying and correcting vitamin D inadequacy in basketball players, a critical synthesis of these data is yet to be performed to overcome the low generalizability of findings from individual studies. Objective: To provide a comprehensive analysis of data in basketball pertaining to (1) the prevalence of vitamin D inadequacy; (2) the effects of vitamin D supplementation on 25-hydroxyvitamin D [25(OH)D] concentration (and its association with body composition), bone health, and performance; and (3) crucial aspects that warrant further investigation. Data Sources: PubMed, MEDLINE, ERIC, Google Scholar, SCIndex, and ScienceDirect databases were searched. Study Selection: After screening, 15 studies were included in the systematic review and meta-analysis. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 3. Data Extraction: The prevalence of vitamin D inadequacy, serum 25(OH)D, body composition, stress fractures, and physical performance were extracted. Results: The pooled prevalence of vitamin D inadequacy for 527 basketball players in 14 studies was 77% ( P < 0.001; 95% CI, 0.70-0.84). Supplementation with 4000 IU/d and 4000 IU/wk (absolute mean difference [AMD]: 25.39 nmol/L; P < 0.001; 95% CI, 13.44-37.33), as well as 10,000 IU/d (AMD: 100.01; P < 0.001; 95% CI, 70.39-129.63) vitamin D restored 25(OH)D to normal concentrations. Body composition data revealed inverse correlations between changes in serum 25(OH)D (from pre- to postsupplementation) and body fat ( r = −0.80; very large). Data concerning positive impacts of vitamin D supplementation on bone health and physical performance remain sparse. Conclusion: The high proportion of vitamin D inadequacy underscores the need to screen for serum 25(OH)D in basketball players. Although supplementation restored vitamin D sufficiency, the beneficial effects on bone health and physical performance remain sparse. Adiposity can modulate 25(OH)D response to supplementation.
The use of mannitol in partial nephrectomy for renal function preservation: meta-analysis and systematic review of comparative studies
Authors: Rivera Kay C , Tiangco Rogerson DG , Aba Luzelle Kate B , Ongkeko Jose Leuel A , Dy Jun S , Chua Michael E 
Published: June 2021

Objective: We aimed to assess the effect and safety of mannitol use in partial nephrectomy for renal function preservation. Methods: A systematic literature search was performed. Randomised controlled trials and non-randomised controlled trials comparing with versus without mannitol use in partial nephrectomy were screened and evaluated according to Cochrane Collaboration recommendations. Outcomes assessed were percentage change from preoperative estimated glomerular filtration rate, estimated blood loss and complications. The standardised mean difference (SMD) and risk ratio (RR) with corresponding 95% confidence intervals were extrapolated. Effect estimates were pooled using the inverse variance method with a random-effects model. Subgroup analysis was performed according to study design and follow-up duration. Grading of recommendations, assessment, development and evaluations assessment was used to rate the quality of evidence. Results: A total of 1136 patients from two randomised controlled trials ( n=264) and six non-randomised controlled trials ( n=872) were included. The included randomised controlled trials had some concerns regarding a high risk of bias; while the non-randomised controlled trials were all retrospective studies with moderate to serious concern for risk of bias. Overall pooled effect estimates for short and long-term follow-up showed no significant differences between intervention groups for percentage change from preoperative estimated glomerular filtration rate (SMD 0.09, 95% confidence interval (CI) −0.11, 0.29; SMD −0.06, 95% CI −0.22, 0.06, respectively). Likewise, no between-group difference was noted for intraoperative blood loss and complication rates (SMD 0.05, 95% CI −0.08, 0.17; RR 1.07, 95% CI 0.6, 1.82, respectively). Conclusion: The pooled effect estimates from both randomised and non-randomised comparative studies illustrated no overall short-term or long-term advantage with mannitol use in partial nephrectomy for the preservation of estimated glomerular filtration rate. Likewise, no difference was noted for intraoperative blood loss or complication rates. However, to date there is only a very low to low quality of evidence available to extrapolate conclusions. Level of evidence: Very low to low
Correlations between macrophage/microglial activation marker sTREM-2 and measures of T-cell activation, neuroaxonal damage and disease severity in multiple sclerosis
Authors: Ioannides Zara A , Csurhes Peter A , Swayne Andrew , Foubert Philippe , Aftab Blake T , Pender Michael P 
Published: June 2021

Background Soluble triggering receptor expressed on myeloid cells-2 (sTREM-2) is a marker of macrophage and microglial activation and is increased in the cerebrospinal fluid (CSF) in multiple sclerosis (MS). Objective To determine the relationships among sTREM-2, T cell activation, neuroaxonal damage and clinical features of MS. Methods Enzyme-linked immunosorbent assays were used to measure the levels of sTREM-2, soluble CD27 (sCD27, a marker of T cell activation), neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (pNfH) in the CSF of 42 patients with MS (including nine with clinically isolated syndrome) and 15 patients with other neurological diseases (OND) and in the serum of 164 patients with MS, 87 patients with OND and 62 healthy controls. Results sTREM-2 was significantly elevated in the CSF ( p = 0.012), but not in the serum, in MS compared to OND. In MS, CSF sTREM-2 correlated positively with CSF sCD27 ( p = 0.005), CSF NfL ( p = 0.0001), CSF pNfH ( p = 0.0006), Expanded Disability Status Scale (EDSS) score ( p = 0.0079) and MS Severity Score (MSSS) ( p = 0.0006). Conclusion In MS the level of sTREM-2 in the CSF is related to measures of T cell activation (sCD27), neuroaxonal damage (NfL and pNfH), disability (EDSS) and disease severity (MSSS).
Geriatric Sinus Surgery: A Review of Demographic Variables, Surgical Success and Complications in Elderly Surgical Patients
Authors: Helman Samuel N. , Carlton Daniel , Deutsch Brian , Choake Robert , Patel Varun , Govindaraj Satish , Iloreta Alfred M. C. , Del Signore Anthony 
Published: June 2021

Objective Demonstrate feasibility, safety and outcome metrics of geriatric sinus surgery (GESS). Study Design Retrospective review of patients undergoing sinus surgery for indication of chronic rhinosinusitis with and without nasal polyposis. Setting Tertiary referral center. Participants Patients who underwent FESS from 2008–2017; excluding skull base, craniofacial, or oncologic surgery. Primary study group were patients aged 65 years and older. Patients aged 40–64 years of age were included for comparison. Main Outcomes and Measures: Multivariate analysis was performed to identify independently associated patient characteristics and perioperative variables. Preoperative medical and treatment history, revision and primary surgery, preoperative and post-operative SNOT-22 and NOSE scores, Lund-McKay scores were recorded when available. Post-operative data was assessed at a minimum of two months after the index procedure. Post-operative complications were included. Results Ninety-one (91) patients met criteria. 21.2% of the geriatric patients were taking systemic anticoagulation prior to surgery, and underwent treatment with nasal steroids (25.0%), oral antibiotics (67.7%), nasal irrigations (48.4%), and systemic steroids (37.5%) over an average of 7.3 months prior to surgery. There was an average post-operative reduction of 15.0 points (p < 0.0001) and 42.5 points (p = 0.0008) for SNOT-22 and NOSE scores, respectively. Average operative time was 117.4 minutes in geriatric patients compared to 183.4 minutes in younger patients (p = 0.004), with an average estimated blood loss of 55.6 milliliters (mL) compared to younger patients (111.8 mL) (p = 0.04). Linear regression identified revision surgery as associated with reductions in Sinonasal Outcome Test (SNOT-22) scores (p = 0.011). Geriatric patients had a shorter operative time (p = 0.011) while male sex was associated with a longer operative time (p = 0.014). Patients over 65 had fewer minor complications (p = 0.01), and there were no major complications in either group. Conclusions and Relevance Geriatric sinus surgery is effective and safe in this cohort of patients.
Body Composition and Selected Nutritional Indicators in Healthy Adults—A Cross-Sectional Study
Authors: Więch Paweł , Chmiel Zdzisława , Bazaliński Dariusz , Sobolewski Marek , Sałacińska Izabela 
Published: June 2021

Background Body mass composition is subject to constant change and is multifactorially determined. Its analysis in different age groups allows a better understanding of the determinants of the human organism in health and disease. Aim The study was aimed to conduct cross-sectional assessment of body composition and selected nutritional indicators in healthy adults. Methods The cross-sectional study carried out from March 2016 to April 2018 was preceded by a monthly pilot study. All 1333 adults (women 795, 59.6%) aged 20–59 included in the study were from the urban and rural area of the Podkarpackie Province (Poland). These adults were classified into four 10-year age bands. To obtain reliable assessment, selected screening (anthropometry) and in-depth (bioelectrical impedance including phase angle and bioelectrical impedance vector analysis) methods were used. Results In women, the proportion of individuals affected by overweight and obesity increases significantly with age, with a less pronounced trend in men, as reflected in the observed differences in individual body composition components. A slight (0.45–0.60) correlation was also observed between body mass index (BMI) and percentage of fat mass (FM %) among men with an increasing strength of the association with age, decreasing in the 50–59 years group. In the female group, the correlations described are at a much higher level (0.80 or higher). The described changes in body composition were reflected in body type from athletic to obese, measured by means of the bioelectrical impedance vector analysis (BIVA) method. Conclusions Age and gender significantly differentiate body composition of the adult human body. The body composition analysis should be considered as complement screening assessment method, especially as a support for the assessment of nutritional status expressed by BMI.
Sparse Autoencoder-based Multi-head Deep Neural Networks for Machinery Fault Diagnostics with Detection of Novelties
Authors: Yang Zhe , Gjorgjevikj Dejan , Long Jianyu , Zi Yanyang , Zhang Shaohui , Li Chuan 
Published: June 2021

AbstractSupervised fault diagnosis typically assumes that all the types of machinery failures are known. However, in practice unknown types of defect, i.e., novelties, may occur, whose detection is a challenging task. In this paper, a novel fault diagnostic method is developed for both diagnostics and detection of novelties. To this end, a sparse autoencoder-based multi-head Deep Neural Network (DNN) is presented to jointly learn a shared encoding representation for both unsupervised reconstruction and supervised classification of the monitoring data. The detection of novelties is based on the reconstruction error. Moreover, the computational burden is reduced by directly training the multi-head DNN with rectified linear unit activation function, instead of performing the pre-training and fine-tuning phases required for classical DNNs. The addressed method is applied to a benchmark bearing case study and to experimental data acquired from a delta 3D printer. The results show that its performance is satisfactory both in detection of novelties and fault diagnosis, outperforming other state-of-the-art methods. This research proposes a novel fault diagnostics method which can not only diagnose the known type of defect, but also detect unknown types of defects.
The evolution of hard tick-borne relapsing fever borreliae is correlated with vector species rather than geographical distance
Authors: Nakao Ranna , Kasama Kentaro , Boldbaatar Bazartseren , Ogura Yoshitoshi , Kawabata Hiroki , Toyoda Atsushi , Hayashi Tetsuya , Takano Ai , Maeda Ken 
Published: June 2021

AbstractBackgroundRelapsing fever (RF) borreliae are arthropod-borne spirochetes and some of them cause human diseases, which are characterized by relapsing or recurring episodes of fever. Recently, it has been classified into two groups: soft tick-borne RF (STRF) borreliae and hard tick-borne RF (HTRF) borreliae. STRF borreliae include classical RF agents and HTRF borreliae, the latter of which includeB. miyamotoi, a human pathogen recently identified in Eurasia and North America.ResultsIn this study, we determined the genome sequences of 16 HTRF borreliae strains: 15B. miyamotoistrains (9 from Hokkaido Island, Japan, 3 from Honshu Island, Japan, and 3 from Mongolia) and aBorreliasp. tHM16w. Chromosomal gene synteny was highly conserved among the HTRF strains sequenced in this study, even though they were isolated from different geographic regions and different tick species. Phylogenetic analysis based on core gene sequences revealed that HTRF and STRF borreliae are clearly distinguishable, with each forming a monophyletic group in the RF borreliae lineage. Moreover, the evolutionary relationships of RF borreliae are consistent with the biological and ecological features of each RF borreliae sublineage and can explain the unique characteristics ofBorrelia anserina. In addition, the pairwise genetic distances between HTRF borreliae strains were well correlated with those of vector species rather than with the geographical distances between strain isolation sites. This result suggests that the genetic diversification of HTRF borreliae is attributed to the speciation of vector ticks and that this relationship might be required for efficient transmission of HTRF borreliae within vector ticks.ConclusionsThe results of the present study, together with those from previous investigations, support the hypothesis that the common ancestor of borreliae was transmitted by hard-bodied ticks and that only STRF borreliae switched to using soft-bodied ticks as a vector, which was followed by the emergence ofBorrelia recurrentis, lice-borne RF borreliae. Our study clarifies the phylogenetic relationships between RF borreliae, and the data obtained will contribute to a better understanding of the evolutionary history of RF borreliae.
De novo genome assembly and analysis unveil biosynthetic and metabolic potentials of Pseudomonas fragi A13BB
Authors: Awolope Opeyemi K. , O’Driscoll Noelle H. , Di Salvo Alberto , Lamb Andrew J. 
Published: June 2021

Abstract
Objectives
The role of rhizosphere microbiome in supporting plant growth under biotic stress is well documented. Rhizobacteria ward off phytopathogens through various mechanisms including antibiosis. We sought to recover novel antibiotic-producing bacterial strains from soil samples collected from the rhizosphere. Pseudomonas fragi A13BB was recovered as part of this effort, and the whole genome was sequenced to facilitate mining for potential antibiotic-encoding biosynthetic gene clusters.

Data description
Here, we report the complete genome sequence of P. fragi A13BB obtained from de novo assembly of Illumina MiSeq and GridION reads. The 4.94 Mb genome consists of a single chromosome with a GC content of 59.40%. Genomic features include 4410 CDSs, 102 RNAs, 3 CRISPR arrays, 3 prophage regions, and 37 predicted genomic islands. Two β-lactone biosynthetic gene clusters were identified; besides, metabolic products of these are known to show antibiotic and/or anticancer properties. A siderophore biosynthetic gene cluster was also identified even though P. fragi is considered a non-siderophore producing pseudomonad. Other gene clusters of broad interest identified include those associated with bioremediation, biocontrol, plant growth promotion, or environmental adaptation. This dataset unveils various un−/underexplored metabolic or biosynthetic potential of P. fragi and provides insight into molecular mechanisms underpinning these attributes.