bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Antenatal Antimicrobial Therapy and Autism Spectrum Disorder—A Nested Case-Control Study
Authors: Abelson Nitzan , Meiri Gal , Solomon Shirley , Flusser Hagit , Michaelovski Analya , Dinstein Ilan , Menashe Idan 
Published: November 2021

Background: Multiple prenatal factors have been associated with autism spectrum disorder (ASD) risk. However, current data about the association between antimicrobial use during pregnancy and ASD is limited.Methods: A nested matched case-control study of children with ASD (cases), and children without ASD or other psychiatric or genetic disorders (controls). We compared the use of antimicrobial therapy during the 3 months before conception or during pregnancy between mothers of cases and controls and used multivariate conditional logistic regression models to assess the independent association between maternal use of antimicrobials during pregnancy and the risk of ASD in their offspring.Results: More than half of the mothers in the study (54.1%) used antimicrobial drugs during the 3 months before conception or during pregnancy. Rates of antimicrobial use were lower for mothers of children with ASD compared to mothers of controls (49.0 vs. 55.1%, respectively; p = 0.02), especially during the third trimester of pregnancy (18.8 vs. 22.9%, respectively; p = 0.03), and for the use of penicillins (15.7 vs. 19.7%, respectively; p = 0.06). These case–control differences suggest that antimicrobial administration during pregnancy was associated with a reduced risk of ASD in the offspring (aOR = 0.75, 95% CI = 0.61–0.92). Interestingly, this association was seen only among Jewish but not for the Bedouin mothers (aOR = 0.62, 95% CI = 0.48–0.79 and aOR = 1.21, 95% CI = 0.82–1.79).Conclusions: The reduced risk of ASD associated with prenatal antimicrobials use only in the Jewish population suggest the involvement of other ethnic differences in healthcare services utilization in this association.
The Willingness of Community Psychiatric Management Physicians to Preferentially Recommend Long-Acting Injections in Beijing
Authors: Jin Lefan , Chen Yun , Zhu Junli , Huang Qingzhi , Li Bin , Xu Ying , Xi Rui , Lu Wei 
Published: November 2021

Background: Severe mental disorders (SMD) impose a heavy burden on individuals, society, and the country. Under the background of deinstitutionalization, more and more patients return to the community, and the community psychiatric management physicians (CPMP) play an essential role in this process. Long-acting injection (LAI) is an important way to improve compliance and reduce re-hospitalization. Some districts in Beijing have implemented the policy of free LAI. This article aims to find out the willingness of CPMP to preferentially recommend LAI and provide suggestions for follow-up promotion.Methods: All CPMP in 16 districts of Beijing were surveyed. A self-made electronic questionnaire was used to investigate the willingness to recommend LAI in priority. Descriptive statistics, Chi-square test, and logistic regression were used to analyze the data.Results: The willingness of CPMP to preferentially recommend LAI is up to 80%. Participants aged 40–49, female, with higher self-evaluation of psychiatric management knowledge, managing patients who have used LAI in the past, and working in communities with the free LAI policy have higher willingness to recommend LAI in priority.Conclusion: CPMP in Beijing have a positive attitude toward LAI, and most of them have the willingness to recommend LAI to the patients in priority. The recommendation willingness is the basis of prescription decision-making. Therefore, the coverage of free LAI policy should be further expanded in the future to improve the recommendation willingness and thus improve the injection rate of LAI.
No Transits of Proxima Centauri Planets in High-Cadence TESS Data
Authors: Gilbert Emily A. , Barclay Thomas , Kruse Ethan , Quintana Elisa V. , Walkowicz Lucianne M. 
Published: November 2021

Proxima Centauri is our nearest stellar neighbor and one of the most well-studied stars in the sky. In 2016, a planetary companion was detected through radial velocity measurements. Proxima Centauri b has a minimum mass of 1.3 Earth masses and orbits with a period of 11.2 days at 0.05 AU from its stellar host, and resides within the star’s Habitable Zone. While recent work has shown that Proxima Centauri b likely does not transit, given the value of potential atmospheric observations via transmission spectroscopy of the closest possible Habitable Zone planet, we reevaluate the possibility that Proxima Centauri b is a transiting exoplanet using data from the Transiting Exoplanet Survey Satellite (TESS). We use three sectors (Sectors 11, 12, and 38 at 2-min cadence) of observations from TESS to search for planets. Proxima Centauri is an extremely active M5.5 star, emitting frequent white-light flares; we employ a novel method that includes modeling the stellar activity in our planet search algorithm. We do not detect any planet signals. We injected synthetic transiting planets into the TESS and use this analysis to show that Proxima Centauri b cannot be a transiting exoplanet with a radius larger than 0.4 R⊕. Moreover, we show that it is unlikely that any Habitable Zone planets larger than Mars transit Proxima Centauri.
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD
Authors: Chen Shirui , Wang Tielong , Luo Tao , He Shujiao , Huang Changjun , Jia Zehua , Zhan Liqiang , Wang Dongping , Zhu Xiaofeng , Guo Zhiyong , He Xiaoshun 
Published: November 2021

Background: Early allograft dysfunction (EAD) is correlated with poor patient or graft survival in liver transplantation. However, the power of distinct definitions of EAD in prediction of graft survival is unclear.Methods: This retrospective, single-center study reviewed data of 677 recipients undergoing orthotopic liver transplant between July 2015 and June 2020. The following EAD definitions were compared: liver graft assessment following transplantation (L-GrAFT) risk score model, early allograft failure simplified estimation score (EASE), model for early allograft function (MEAF) scoring, and Olthoff criteria. Risk factors for L-GrAFT7 high risk group were evaluated with univariate and multivariable logistic regression analysis.Results: L-GrAFT7 had a satisfied C-statistic of 0.87 in predicting a 3-month graft survival which significantly outperformed MEAF (C-statistic = 0.78, P = 0.01) and EAD (C-statistic = 0.75, P &lt; 0.001), respectively. L-GrAFT10, EASE was similar to L-GrAFT7, and they had no statistical significance in predicting survival. Laboratory model for end-stage liver disease score and cold ischemia time are risk factors of L-GrAFT7 high-risk group.Conclusion: L-GrAFT7 risk score is capable for better predicting the 3-month graft survival than the MEAF and EAD in a Chinese cohort, which might standardize assessment of early graft function and serve as a surrogate endpoint in clinical trial.
Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury
Authors: Goetzl Laura , Stephens Angela J. , Schlesinger Yechiel , Darbinian Nune , Merabova Nana , Hillel Miriam , Hirsch Alec J. , Streblow Daniel N. , Frias Antonio E. , Roberts Victoria H. J. , Haese Nicole N. , Mani Arunmani , Eldar-Yedidia Yifat 
Published: November 2021

Introduction: Extracellular vesicles derived from the fetal central nervous system (FCNSEs) can be purified from maternal serum or plasma using the protein Contactin-2/TAG1that is expressed almost exclusively by developing neurons in the hippocampus, cerebral cortex and cerebellum. We hypothesized that fetal CNSEs could be used to non-invasively detect and quantify viral mediated in-utero brain injury in the first trimester.Materials and Methods: First trimester maternal samples were collected from a human clinical population infected with primary cytomegalovirus (CMV) and a non-human primate model of Zika (ZIKV) infection. In the CMV cohort, a nested case control study was performed comparing pregnancies with and without fetal infection. Cases of fetal infection were further subdivided into those with and without adverse neurologic outcome. ZIKV samples were collected serially following maternal inoculation or saline. All ZIKV cases had histopathologic findings on necropsy. Serum was precipitated with ExoQuick solution and FCEs were isolated with biotinylated anti-Contactin-2/TAG1 antibody-streptavidin matrix immunoabsorption. FCE Synaptopodin (SYNPO) and Neurogranin (NG) protein levels were measured using standard ELISA kits and normalized to the exosome marker CD81.Results: Fetal CNSE SYNPO and NG were significantly reduced in cases of first trimester fetal CMV infection compared to those with infection limited to the mother but could not discriminate between fetal infection with and without adverse neurologic outcome. Following ZIKV inoculation, fetal CNSE SYNPO was reduced by 48 h and significantly reduced by day 4.Discussion: These data are the first to suggest that first trimester non-invasive diagnosis of fetal viral infection is possible. Fetal CNSEs have the potential to augment clinical and pre-clinical studies of perinatal viral infection. Serial sampling may be needed to discriminate between fetuses that are responding to treatment and/or recovering due to innate defenses and those that have ongoing neuronal injury. If confirmed, this technology may advance the paradigm of first trimester prenatal diagnosis and change the calculus for the cost benefit of CMV surveillance programs in pregnancy.
Rendering Multivariate Statistical Models for Genetic Diversity Assessment in A-Genome Diploid Wheat Population
Authors: Sarfraz Zareen , Shah Mohammad Maroof , Iqbal Muhammad Sajid , Nazir Mian Faisal , Al-Ashkar Ibrahim , Rehmani Muhammad Ishaq Asif , Shahid Iqbal Muhammad , Ullah Najeeb , El Sabagh Ayman 
Published: November 2021

Diversifying available natural resources to cope with abrupt climatic changes and the necessity to equalize rising agricultural production with improved ability to endure environmental influence is the dire need of the day. Inherent allelic variability regarding significant economic traits featuring both enhanced productivity and environmental adaptability is one such prominent need. To address this requirement, a series of analyses were conducted in this study for exploring natural diploid wheat germplasm resources. The current study involved 98 Recombinant Inbred Lines (RILs) populations developed by crossing two diploid ‘A’ sub-genome wheat species, Triticummonococcum and Triticum boeoticum, enriched with valuable alleles controlling, in particular, biotic and abiotic stresses tolerance. Their 12 phenotypic traits were explored to reveal germplasm value. All traits exhibited vast diversity among parents and RILs via multivariate analysis. Most of the investigated traits depicted significant (p < 0.05) positive correlations enlightening spikelet per spike, total biomass, seed weight per spike, number of seeds per spike, plant height, and days to heading as considerably focused traits for improving hexaploid wheat. Principal component analysis (PCA) exhibited 61.513% of total variation with three PCs for 12 traits. Clustering of genotypes happened in three clades, and the two parents were separated into two extreme clusters, validating their enrichment of diversity. This study provided beneficial aspects of parental resources rich in diverse alleles. They can be efficiently exploited in wheat improvement programs focusing on introgression breeding and the recovery of eroded genetic factors in currently available commercial wheat cultivars to sustain calamities of environmental fluctuations.
Feature-Based Molecular Networking—An Exciting Tool to Spot Species of the Genus Cortinarius with Hidden Photosensitizers
Authors: Hammerle Fabian , Quirós-Guerrero Luis , Rutz Adriano , Wolfender Jean-Luc , Schöbel Harald , Peintner Ursula , Siewert Bianka 
Published: November 2021

Fungi have developed a wide array of defense strategies to overcome mechanical injuries and pathogen infections. Recently, photoactivity has been discovered by showing that pigments isolated from Cortinarius uliginosus produce singlet oxygen under irradiation. To test if this phenomenon is limited to dermocyboid Cortinarii, six colourful Cortinarius species belonging to different classical subgenera (i.e., Dermocybe, Leprocybe, Myxacium, Phlegmacium, and Telamonia) were investigated. Fungal extracts were explored by the combination of in vitro photobiological methods, UHPLC coupled to high-resolution tandem mass spectrometry (UHPLC-HRMS2), feature-based molecular networking (FBMN), and metabolite dereplication techniques. The fungi C. rubrophyllus (Dermocybe) and C. xanthophyllus (Phlegmacium) exhibited promising photobiological activity in a low concentration range (1–7 µg/mL). Using UHPLC-HRMS2-based metabolomic tools, the underlying photoactive principle was investigated. Several monomeric and dimeric anthraquinones were annotated as compounds responsible for the photoactivity. Furthermore, the results showed that light-induced activity is not restricted to a single subgenus, but rather is a trait of Cortinarius species of different phylogenetic lineages and is linked to the presence of fungal anthraquinones. This study highlights the genus Cortinarius as a promising source for novel photopharmaceuticals. Additionally, we showed that putative dereplication of natural photosensitizers can be done by FBMN.
Features of the course of new coronaviral infection (COVID-19) in patients with acute kidney injury and end stage renal failure
Authors: Agranovich N. V. , Tkachenko L. I. , Knyshova S. A. , Titorenko M. V. , Lichacheva A. P. 
Published: November 2021

BACKGROUND. In the modern era, COVID-19 is the biggest problem facing doctors and scientists around the world. SARSCоV-2 is a multisystem infection that is not limited to lung damage and has the immuno-mediated effect of negative effects on organs and systems, including the kidneys. To date, there is no precise understanding of the pathogenesis of nephrological disorders in patients with COVID-19. Patients with chronic kidney disease (CKD) are a group of particularly high risk of CO-VID-19 infection and high mortality in the development of the disease.THE AIM: to evaluate the features of the course of a new coronavirus infection (COVID 19) in patients with acute kidney injury and terminal renal insufficiency.PATIENTS AND METHODS. The study of clinical, laboratory and instrumental parameters was carried out in 119 patients (67 men and 52 women) diagnosed with COVID-19. The average age of the patients was 63.1±1.7 years. All patients were divided into two groups: group 1 - patients with CKD and HD, group 2 - patients with newly diagnosed kidney damage against the background of coronavirus infection (COVID-19). Statistical data analysis was carried out using the software package "IBM SPSS Statistics 21.0" (USA) (Russified version).RESULTS. As a result of the study, it was found that in the clinical picture of COVID-19 patients suffering from CKD and undergoing hemodialysis, such a symptom as myalgia was noted 2 times more often, the percentage of saturation of arterial blood hemoglobin with oxygen (SaO2,%) was significantly lower compared to patients with newly diagnosed kidney damage on the background of infection. The duration of the temperature reaction during the disease was 5 times longer than in patients without CKD. Although the incidence of lung damage in patients of both groups was identical, mortality was significantly higher in the group of patients with CKD.CONCLUSION. In the patients examined by us, proteinuria, an increase in the level of nitrogenous metabolites, as well as D-dimers in both groups, are associated with increased mortality. Mortality in patients with CKD and HD was several times higher than in those without pathology of the urinary system. The severity of the patients' condition was primarily due to the symptoms of damage to the respiratory system, but the degree of renal dysfunction is undoubtedly an important prognostic value. Thus, monitoring the state of individual nephron structures in patients with CO-VID-19 is of great importance, and emergency nephroprotective measures may be crucial in the fight against cytokine storm.
Evaluation of the level of natriuretic peptides in the diagnosis and characterization of chronic kidney disease and cardiorenal syndrome in children
Authors: Mambetova A. M. , Bizheva D. V. , Thabisimova I. K. 
Published: November 2021

BACKGROUND. Natriuretic peptides have cardio- and renoprotective effects, inhibiting inflammatory and proliferative processes. The role of natriuretic peptides in the early diagnosis and characterization of chronic kidney disease (CKD) and cardiovascular complications as the disease development and progresses has not been studied.TNEAIM: to study the level of natriuretic peptides in children depending on the stage of CKD development and to assess the significance of this indicator.PATIENTS AND METHODS. The study involved 93 children with congenital diseases of the urinary system at the age from 3 to 18 years. Three groups were identified: group I - 54 patients with CKD stage I , group II - 29 patients with CKD stage II; Group III - 10 children with CKD stages IV-V (patients with CKD stages IV and V were combined due to their small amount). Control group - 10 clinically healthy children of the corresponding age. The N-terminal propeptide of natriuretic hormone (NT-proBNP) was determined in the blood by the enzyme-linked immunosorbent assay.RESULTS. An increase in the level of NT-proBNP by 28.7% takes place already in the early stages of CKD. With the progression of CKD, an increase in the level of NT-proBNP was noted from 57.4 % in children in the group of patients with stage I CKD to 80 % in children in group III patients. The maximum concentrations of NT-proBNP, many times higher than those in CKD stages I and II, were observed in children with CKD stages IV-V. The degree of increase in the level of NT-proBNP correlated with the severity of CKD.CONCLUSION. In the diagnosis and characterization of CKD and cardiorenal syndrome in children, the determination of the level of natriuretic peptides is of great importance. A high level of natriuretic peptides characterizes the presence of cardiorenal relationships and can be used as an additional criterion for assessing the severity of CKD, including at the early stages of its development.
ON THE LEGAL MECHANISM OF RESTRICTION OF CONSTITUTIONAL HUMAN AND CIVIL RIGHTS IN ORDER TO ENSURE SECURITY
Authors: Языкеев Сергей Николаевич 
Published: November 2021

В статье анализируется правовой механизм ограничения конституционных прав человека и гражданина в целях обеспечения безопасности. Автор приходит к выводу о необходимости закрепления в Федеральном законе «О безопасности» правового механизма ограничения прав и свобод человека и гражданина в целях обеспечения безопасности, который будет распространяться в том числе и на специальное законодательство.
The article analyzes the legal mechanism of restricting the constitutional rights of a person and a citizen in order to ensure security. The author comes to the conclusion that it is necessary to consolidate in the Federal Law "On Security" a legal mechanism for restricting human and civil rights and freedoms in order to ensure security, which will also apply to special legislation.
CYBERCRIME TRENDS IN THE RUSSIAN FEDERATION
Authors: Тарасова Юлия Владимировна 
Published: November 2021

В данной статье раскрывается понятие киберпреступности, которая характеризуется сложной структурой и большим разнообразием совершаемых в этой сфере общественно опасных деяний. В статье представлены актуальные на сегодняшний день тенденции с приведением примеров, рассмотрены факторы латентности киберпреступности.
This article reveals the concept of cybercrime, which is characterized by a complex structure and a wide variety of socially dangerous acts committed in this area. This topic is relevant because in the modern world the sphere of computer technologies is rapidly developing, the use of which, on the one hand, has made the life of users easier, on the other hand, their use is far from safe. The article presents current trends with examples, considers the factors of cybercrime latency .
GW200115: A Nonspinning Black Hole–Neutron Star Merger
Authors: Mandel Ilya , Smith Rory J. E. 
Published: November 2021

Abstract
GW200115 was the second merger of a black hole and a neutron star confidently detected through gravitational waves. Inference on the signal allows for a large black hole spin misaligned with the orbital angular momentum, but shows little support for aligned spin values. We show that this is a natural consequence of measuring the parameters of a black hole–neutron star binary with nonspinning components while assuming the priors used in the LIGO–Virgo–KAGRA analysis. We suggest that, a priori, a nonspinning binary is more consistent with current astrophysical understanding.
Recurrent Activity from Active Asteroid (248370) 2005 QN173: A Main-belt Comet
Authors: Chandler Colin Orion , Trujillo Chadwick A. , Hsieh Henry H. 
Published: November 2021

Abstract
We present archival observations of main-belt asteroid (248370) 2005 QN173 (also designated 433P) that demonstrate this recently discovered active asteroid (a body with a dynamically asteroidal orbit displaying a tail or coma) has had at least one additional apparition of activity near perihelion during a prior orbit. We discovered evidence of this second activity epoch in an image captured 2016 July 22 with the DECam on the 4 m Blanco telescope at the Cerro Tololo Inter-American Observatory in Chile. As of this writing, (248370) 2005 QN173 is just the eighth active asteroid demonstrated to undergo recurrent activity near perihelion. Our analyses demonstrate (248370) 2005 QN173 is likely a member of the active asteroid subset known as main-belt comets, a group of objects that orbit in the main asteroid belt that exhibit activity that is specifically driven by sublimation. We implement an activity detection technique, wedge photometry, that has the potential to detect tails in images of solar system objects and quantify their agreement with computed antisolar and antimotion vectors normally associated with observed tail directions. We present a catalog and an image gallery of archival observations. The object will soon become unobservable as it passes behind the Sun as seen from Earth, and when it again becomes visible (late 2022) it will be farther than 3 au from the Sun. Our findings suggest (248370) 2005 QN173 is most active interior to 2.7 au (0.3 au from perihelion), so we encourage the community to observe and study this special object before 2021 December.
Unusual Emission Variations Near the Eclipse of Black Widow Pulsar PSR J1720−0533
Authors: Wang S. Q. , Wang J. B. , Wang N. , Yao J. M. , Hobbs G. , Dai S. , Kou F. F. , Miao C. C. , Li D. , Feng Y. , Dang S. J. , Wang D. H. , Wang P. , Yuan J. P. , Zhang C. M. , Zhang L. , Zhang S. B. , Zhu W. W. 
Published: November 2021

Abstract
We report on an unusually bright observation of PSR J1720−0533 using the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The pulsar is in a black widow system that was discovered by the Commensal Radio Astronomy FAST Survey (CRAFTS). By coincidence, a bright scintillation maximum was simultaneous with the eclipse in our observation, which allowed for precise measurements of flux density variations, as well as dispersion measure (DM) and polarization. We found that there are quasi-periodic pulse emission variations with a modulation period of ∼22 s during the ingress of the eclipse, which could be caused by plasma lensing. No such periodic modulation was found during the egress of the eclipse. The linear polarization of the pulsar disappears before the eclipse, even before there is a visually obvious change in DM. We also found that the pulse scattering may play an important role in the eclipse of PSR J1720−0533.