bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyridazinone: Current Progress in Synthesis of its Derivatives and Biological Activity
Authors: Pathak Shilpi , Sharma Vishnu , Agrawal Neetu , Sharma Sangeeta 
Published: December 2024

Abstract:
Pyridazinone, a six-membered heterocyclic molecule, has emerged as an important
pharmacophore in drug discovery due to its diverse range of biological actions. This adaptable scaffold
has shown tremendous promise in the development of therapeutic medicines for a variety of
pharmacological conditions, including anti-inflammatory, anti-cancer, anti-microbial, cardiovascular,
and central nervous system illnesses. Pyridazinone derivatives are useful in medicinal chemistry
due to their propensity to interact with a wide range of biological targets. This review offers a
comprehensive overview of Pyridazinone-based compounds, focusing on their chemical structure,
mechanism of action, structure-activity relationship (SAR), and therapeutic uses. Current trends in
Pyridazinone research and its potential as a lead chemical for new medication development are also
reviewed. Pyridazinone broad range of activity and adaptability highlight its importance in developing
pharmacotherapy.
Biomaterials used to Deliver Drugs for Colon Cancer Management
Authors: Badoniya Namita , Sharma Manu 
Published: December 2024

Abstract:
Despite the major advancements in cancer treatment, colon cancer (CC) is still one of
the most lethal malignancies worldwide. Among various type of cancer, it is the third largest
prevailing kind of cancer affecting both men and women equally. Metastatic development is particularly
common in individuals with advanced stages and frequently associated with subpar response
of chemotherapy and severe morbidity. The unfavorable effects of intense chemotherapy
on normal cells and emergence of multidrug resistance are the two main reasons for treatment
failure. Recent research in nanotechnology enables the use of advanced natural and synthetic
biomaterials alone or in combination to target cancer cells with anticancer medications without
affecting healthy cells. Anticancer drug laden nanocarriers improve the drug distribution, bioavailability
and accumulation of cytotoxic therapeutic concentration at tumor site along with reduced
side effects. Additionally, upon oral administration, polymeric vehicles shield the medication
from premature release, degradation in upper gastrointestinal tract and facilitate controlled
release at cancerous site of colon. Here, we primarily focus on the present situation and possible
advantages of polymeric biomaterials either owned or in conjunction with other therapeutics to
develop ideal drug carrier systems to treat colon carcinoma.
A Novel Optimization Method for Vehicle Routing Problem with Fuzzy Time Windows through Intermediate Bulk Container Sharing under Fuzzy Demands Environment
Authors: Pan Yiying , Zhou Zhaoxin , Zhang Fangwei , Ni Huan , Wang Rui 
Published: December 2024

Introduction:
The research focuses on cost optimization in the traditional vehicle routing
optimization problem. However, in the actual optimization scenarios, such as port industrial
parks, decision-makers often focus on service time and customer demands under uncertain environments.

Methods:
Meanwhile, increasing environmental sustainability and effective resource utilization
further drive the focus on eco-friendly transportation. In this context, this study refines a Hazmat
Vehicle Routing Problem with Fuzzy Time Windows under Fuzzy Demands for the port industrial
park. Moreover, to address the above problems, the main contributions of this study are as follows.
Firstly, inspired by the sharing economy theory, a novel mode is proposed through Intermediate
Bulk Container sharing as a transportation medium in the port industrial park. Secondly, a
bi-objective fuzzy chance-constrained programming model is proposed for transportation cost and
service satisfaction, considering fuzzy demands and fuzzy time windows.

Results:
Thirdly, the non-dominated sorting genetic algorithm II is used to solve the proposed
problem. Additionally, the effectiveness of the model is validated using the Solomon benchmark
with different scales, where transportation costs are 11545, 28611, and 61192, and average satisfaction
is 0.89, 0.88, and 0.92.

Conclusion:
The results indicate that the algorithm reduces transportation costs and enhances service
satisfaction. The study enriches the relevant research on vehicle routing problems and provides
a theoretical basis for practical distribution strategies.
The correlation of nutrition knowledge with dietary diversity and nutritional status of pregnant women
Authors: Putra Muh. Guntur Sunarjono , Kustiyah Lilik , Dewi Mira 
Published: December 2024

<p><strong>Background:</strong><strong> </strong>The mortality rate among pregnant women has witnessed an escalation in both Indonesia and West Java. One contributing factor to this phenomenon is maternal malnutrition or chronic energy deficiency, exerting detrimental effects on both the developing fetus and the expectant mother.</p><p><strong>Objectives:</strong><strong> </strong>This study examined the correlation of nutrition knowledge, dietary diversity, and nutritional status of pregnant women.</p><p><strong>Methods:</strong> This study used a cross-sectional design with 40 pregnant women as subjects using a simple random sampling technique in the working area of the Cikembar Community Health Center, Sukabumi Regency. Data collection was carried out from February 21 to March 3, 2019. The variables studied in this study consisted of subject and socio-economic characteristics, anthropometry of pregnant women, nutritional knowledge, and food consumption, which were assessed using multiple 24-hour recalls. The statistical tests used include descriptive and bivariate tests using the Spearman Test.</p><p><strong>Results:</strong> The prevalence of CED pregnant women was 52.5%, the level of nutritional knowledge was moderate (47.5%), and food consumption was not diverse (45.0%). There is a significant correlation between nutritional knowledge and diet quality in mothers, reflected in the diversity of food consumption (p= 0.032; r= 0.340). There was also a significant correlation between nutritional knowledge, BMI before pregnancy (p= 0.032; r= 0.339), and MUAC (p= 0.016; r= 0.378).</p><p><strong>Conclusions:</strong><strong> </strong>Enhanced nutrition knowledge was associated with improved dietary diversity, BMI before pregnancy, and MUAC. These outcomes suggest that nutrition and health education pertaining to pregnancy are crucial for prospective mothers to prioritize and enhance.</p>
Improving Arabic language speaking skill of non-Arabic students in Karabuk University
Authors: Ashari Riza , Huwaida Jaziela , Nikaso Flora , Aini Rihan Nurul 
Published: December 2024

The lack of understanding of Arabic among non-Arabic students at the Faculty of Divinity at Karabuk University is one of the factors that hinder them from understanding lessons, especially in courses such as qira'ah, tafsir, hadith, and others. This lack of language mastery causes difficulties in comprehending materials that requires a deep understanding of Arabic texts. Thus, this project aims to conducting several activities to improve and broaden the knowledge of students at Karabuk university. The subjects of this activity were 40 students from Karabuk University. The methods used implemented were direct methods and question and answer methods, through several stages of implementation, namely preparation, implementation, and monitoring and evaluation. The results of the implementation of this activity show that the students managed to gain a deeper understanding of the Arabic language learning methods applied in Gontor. This insight is not only limited to theory, but also involves direct practice as shown through the active interaction between Santri and Turkish presenters during the teaching process. This interaction is an important element, as it allows santri to experience teaching approaches from different perspectives and interact with international teachers, which enriches their learning experience. Thus, this activity not only increases the santri’s knowledge of teaching methods, but also builds cross-cultural communication abilities and strengthens their Arabic language skills through hands-on practice and guidance from experienced presenters.
TO THE MATHEMATICAL ESTIMATION OF THE STRAIN SENSORS ERROR
Authors: Rogacheva Nelly , Sidorov Vladimir , Zheglova Yulia 
Published: December 2024

The work is devoted to the mathematical analysis of the error of the theory of strain sensors. In the theory of deformation sensors, it is assumed that the sensor, due to its geometric and mechanical characteristics, does not make changes (or makes minor changes) to the stress-strain state (SSS) of the tested structure. To numerically estimate the sensor error, an exact solution of the dynamic contact problem of the sensor and the elastic half-space is obtained. For the analytical solution of the problem, the method used by Lamb to determine the dynamic stress-strain state of an elastic half-space under the action of concentrated forces applied to its surface is generalized. A numerical solution of this problem has been performed for sensors and elastic half-space made of various materials. Practical recommendations are formulated. A numerical solution of this problem has been performed.
Personal resilience, good leadership, and a psychologically safe culture play a mitigating role on the impact of patient safety events
Authors: Kogan Lori R. , Low Rochelle , Baldwin Johanna , Brown Emma 
Published: December 2024

Abstract

OBJECTIVE
To assess the impact of patient safety events on veterinary professionals and identify factors influencing their responses.

METHODS
This was an experimental study, wherein a total of 2,182 veterinary professionals in the US, including veterinarians, technicians, assistants, client service providers, and managers/directors, were given an anonymous online survey utilizing the Second Victim Experience and Support Tool, Brief Resilience Scale, and Team Psychological Safety Scale.

RESULTS
The majority of participants reported having experienced at least 1 patient safety event within the last 12 months. This number was highest for veterinarians (79%), followed by managers/directors (74%) and veterinary technicians (67%). Approximately 50% of veterinarians, veterinary technicians, and veterinary assistants who reported being involved in a patient safety event indicated at least 1 of these events caused serious harm. The majority of those involved in a patient safety event reported that they talked to their supervisor about the incident (79% of veterinarians, 83% of veterinary technicians, and 83% of veterinary assistants). The most desired types of support participants wanted after a patient safety event included access to a respected peer to discuss the details of what happened (71%), a specified peaceful location available to recover and recompose (64%), and an employee assistance program that provides free counseling (61%).

CONCLUSIONS
Patient safety events significantly impacted veterinary professionals’ well-being and career intentions.

CLINICAL RELEVANCE
Enhancing personal resilience, developing and promoting transformational leadership training programs, and fostering a psychologically safe team culture can mitigate negative effects and improve overall patient safety.
2024 analysis of compensation, job duties, and benefits among US shelter medicine veterinarians
Authors: Kreisler Rachael E. , Spindel Miranda E. , Rishniw Mark 
Published: December 2024

Abstract

OBJECTIVE
To understand the salary, benefits, hours, and job duties of shelter medicine veterinarians.

METHODS
Similar to a 2018 survey, an anonymous survey on compensation and duties of shelter medicine veterinarians was conducted via a commercial platform from January 4 to 31, 2024. The survey was distributed through social media, message boards, and specialty listservs. Participants were categorized into part-time clinical veterinarians, full-time clinical veterinarians, academic faculty, and leadership/consultants.

RESULTS
299 US shelter veterinarians responded: 258 were engaged in clinical work (198 working full time and 60 part time), 18 worked in academia, and 23 held leadership/consulting roles. Full-time clinical veterinarians reported a median salary of $122,500, reflecting a 25% increase since 2018. Part-time clinicians earned $85/h—a 77% increase—while working a median of 24 h/wk. Faculty had a median salary of $130,000, a 20% increase. Those in leadership or consulting roles earned a median of $168,000, a 40% increase.

CONCLUSIONS
Salaries increased across all categories, with the highest increase for leadership/consulting roles and the lowest for academic positions. Part-time veterinarians saw a large rise in hourly rates, while working fewer hours. Leadership positions yielded the highest incomes, followed by faculty. Clinical salaries were 5% lower than the AVMA-reported 2022 salaries for private practice veterinarians and 7% lower for companion animal veterinarians.

CLINICAL RELEVANCE
Understanding these compensation trends assists shelter veterinarians in making informed career decisions and negotiations. Despite salary increases, shelter veterinarians’ earnings remain lower than those in private practice.
Difficult Course of a Teenager’s Cardiogenic Shock
Authors: Iurian Diana-Ramona , Chiperi Lăcrămioara Eliza , Stroe Valentin , Pașcanu Sorin , Muntean Iolanda 
Published: December 2024

Abstract
Fulminant myocarditis is a peculiar condition characterized by sudden-onset diffuse myocardial inflammation leading to hemodynamic compromise. We report the case of a 15-year-old male adolescent, without any cardiovascular history, who presented sudden-onset severe biventricular systolo-diastolic dysfunction leading to cardiogenic shock, 2 weeks after an episode of respiratory tract infection. A comprehensive treatment regimen was initiated including heart failure treatment, inotropic and vasoactive support, antibiotics, antiviral treatment, intravenous immunoglobulin, and glucocorticoids, but with poor evolution. Bridge-to-transplantation therapy was taken into consideration for hemodynamic stabilization. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support was initiated, first peripherally, via femoral artery and femoral vein access, but secondary to left ventricle (LV) distension, the patient developed pulmonary edema. To decompress the LV, an echocardiography-guided atrial septostomy was performed, and after 2 days, central cannulation (right atrium – ascending aorta) with another cannula for left atrial venting was done, and the patient remained with open sternum. Five days from the initiation of VA-ECMO the patient underwent an orthotopic heart transplantation by bicaval technique with favorable evolution in the follow-up period. Early initiation of VA-ECMO is a salvage intervention in pediatric patients with fulminant myocarditis, but with multiple possible complications. This paper highlights strategies for the optimization of VA-ECMO.
Interaksi Antara Parameter Kuat Geser Tanah dan Adhesi Tanah Geosintetik pada Tanah Berpasir
Authors: Simatupang Pintor Tua , Fitriani Eka Nur 
Published: December 2024

Material geosintetik telah diterapkan sebagai bahan material teknik sipil di bidang geoteknik. Dalam perencanaan perkuatan tanah dengan geosintetik diperlukan parameter kekuatan geser antara geosintetik dengan tanah. Telah dilakukan studi sebelumnya mengenai parameter kuat geser tanah dengan menggunakan pengujian uji geser langsung, akan tetapi pengujian masih terbatas pada material geosintetik berupa woven geotextile, nonwoven geotextile, dan geomembran sedangkan saat ini sudah berkembang material geosintetik lainnya yang digunakan sebagai perkuatan pada tanah. Penelitian ini bertujuan untuk mengetahui parameter kuat geser tanah antara geosintetik dan tanah dengan menggunakan pengujian uji geser langsung. Material geosintetik yang digunakan yaitu woven geotextile, nonwoven geotextile, geomembran, geocomposite, dan geogrid. Jenis tanah yang digunakan merupakan tanah pasir yang ada di pantai Pangandaran dan 2 sampel tanah yang terdapat di daerah Kabupaten Pangandaran. Analisis dilakukan terhadap hasil pengujian uji geser langsung antara geosintetik dan tanah. Jenis tanah yang digunakan merupakan tanah pasir yang ada di pantai Pangandaran, tanah Cijulang dan tanah Cimerak. Analisis dilakukan terhadap hasil pengujian uji geser langsung antara geosintetik dan tanah. Dari hasil pengujian didapatkan bahwa kekuatan geser antar muka yang terjadi tidak hanya dipengaruhi oleh jenis material geosintetik saja, akan tetapi butiran tanah juga mempengaruhi pada kekuatan geser antar muka yang dihasilkan. Ketiga sampel tanah merupakan tanah yang mengandung pasir, sehingga untuk tanah berpasir nilai rasio d/f pada geogrid berkisar antara 0,83 – 0,96; geotekstile woven nilai rasio d/f berikisar antara 0,78 – 0,88; pada geocomposite yang merupakan gabungan antara geotekstile non woven yang diperkuat dengan serat-serat polyester memiliki nilai rasio d/f berkisar antara 0,70 – 0,80; pada geotekstil non woven berkisar antara 0,69 – 0,79 sedangkan geomembrane nilai rasio d/f berkisar antara 0,54 – 0,62.
Prediksi Dampak Endapan Sedimen Hasil Erupsi 2023 terhadap Karakteristik Banjir Lahar di Kali Krasak Menggunakan SIMILAR
Authors: Rohman Fahrul , Ikhsan Jazaul , Hairani Ani 
Published: December 2024

Gunung Merapi merupakan salah satu gunung api di Indonesia yang masih aktif. Pada tahun 2023 Gunung Merapi mengalami erupsi, daerah yang terdampak diantaranya DAS Krasak. Erupsi gunung api merupakan fenomena alam yang dapat menimbulkan bahaya. Salah satu akibat dari erupsi gunung api adalah banjir lahar. Banjir lahar dapat menyebabkan kerusakan dan timbulnya korban jiwa. Salah satu upaya untuk mengurangi angka korban jiwa dan kerugian material yaitu dengan prediksi. Penelitian ini mengunakan aplikasi SIMLAR V2.1 yang didasarkan pada teori Ashida, Takashi dan Mizuyama menggunakan hidrograf sintetis Nakayasu. Pengujian dilakukan dengan membandingkan hasil simulasi tanpa bangunan sabo dan simulai dengan bangunan sabo. Dari hasil pengujian didapatkan kecepatan, luasan banjir, volume, dan nilai agradasi dan degradasi. Nilai luas sebaran pada simulasi tanpa bangunan sabo didapatkan pada curah hujan 58,1 mm sebesar 2,16 km2, curah hujan 87,15 mm sebesar 3,10 km2, dan curah hujan 116,2 mm sebesar 3,85 km2, sedangkan nilai luas sebaran pada simulasi dengan bangunan sabo pada curah hujan 58,1 mm sebesar 1,78 km2, curah hujan 87,15 mm sebesar 2,40 km2, dan curah hujan 116,2 mm sebesar 2,93 km2. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa curah hujan sangat berpengaruh terhadap dampak banjir lahar semakin tinggi curah hujan maka semakin besar luas wilayah yang terdampak banjir lahar. Berdasarkan simulasi tersebut bangunan sabo efektif untuk mengurangi luasan banjir lahar.
Pengaruh Kondisi Alat Berat Terhadap Kelancaran Pekerjaan Pada Proyek Pembangunan Kolam Regulasi Nipa – Nipa
Authors: Tuwo Mustamin , Mustamin Muhammad Rifaldi 
Published: December 2024

Meneliti pengaruh kondisi alat berat terhadap kelancaran pekerjaan sangat penting untuk mengidentifikasi faktor-faktor yang mempengaruhi kinerja alat berat dan bagaimana hal tersebut berdampak pada keseluruhan proyek. Dengan memahami hubungan ini, pihak manajemen proyek dapat mengambil langkah-langkah yang tepat untuk meminimalkan gangguan, meningkatkan efisiensi, dan mengoptimalkan penggunaan sumber daya. Oleh karena itu, penelitian ini manganalisis bagaimana kondisi alat berat mempengaruhi kelancaran pekerjaan pada Proyek Pembangunan Kolam Regulasi Nipa-Nipa. Alat berat harus bekerja dengan baik agar proyek dapat diselesaikan tepat waktu. Dalam pelaksanaan konstruksi terdapat pengaruh – pengaruh dalam kelancaran pekerjaan proyek termasuk pengaruh dari alat berat tersebut. Penelitian ini dilakukan dengan menggunakan metode kuantitatif. Data yang dibutuhkan berupa kuesioner penilaian terhadap proyek pembangunan kolam regulasi nipa - nipa. Data yang diperoleh dari penilaian responden kemudian dianalisis untuk mendapatkan faktor yang paling berpengaruh pada kondisi alat berat terhadap kelancaran Proyek Pembangunan Kolam Renang Regulasi Nipa - Nipa. Berdasarkan hasil penelitian diketahui bahwa faktor yang paling berpengaruh pada kondisi alat berat terhadap kelancaran pekerjaan Proyek Pembangunan Kolam Regulasi Nipa - Nipa yaitu pada excavator X1.2 (menganalisis metode pelaksanaan cara kerja Excavator di lapangan), pada bulldozer X2.6 (mengecek mobilisasi Bulldozer menuju ke proyek), pada dumptruck X3.12 (perawatan alat), pada vibro roller X4.14 (kondisi lokasi/lahan yang akan dikerjakan oleh Vibro Roller), dan pada water tank truck X5.14 (faktor cuaca pada saat alat bekerja).
PENGARUH LATIHAN OBSTACLE RUN TERHADAP PENINGKATAN DAYA TAHAN KARDIOVASKULAR ATLET DEPOK TRAIL RUNNING ACADEMY
Authors: Hutabarat Ilona Pratiwi 
Published: December 2024

Penelitian ini dilatarbelakangi dengan rendahnya VO2 max atlet Detrac. Terutama pada daya tahan tubuh atlet Detrac. Penggunaan latihan Obstacle Run dapat membantu atlet dalam meningkatkan daya tahan. Adapun tujuan dari penelitian ini yaitu untuk Untuk mengetahui adakah pengaruh latihan Obstacle Run terhadap peningkatan daya tahan Cardiovascular pada atlet Detrac. Penelitian ini menggunakan pendekatan kuantitatif dengan metode quasi eksperimen. Adapun sumber data pada penelitian ini yaitu dari data-data penelitian di lapangan baik dari dokumentasi latihan atlet maupun pemberian treatment, data-data tersebut diperluas dengan data yang bersumber dari beberapa referensi buku. Kegiatan penelitian ini dilakukan di Sentul pada atlet Detrac, yang diambil 15 atlet sebagai kelompok eksperimen. Penelitian ini menggunakan uji t independent untuk mencari perbedaan variabel X terhadap Y. Analisis data menggunakan uji t dengan taraf signifikansi 0,05 dengan jumlah sampel 15 responden dengan hasil 0,002 < 0,05 maka terdapat perbedaan. Berdasarkan analisis data yang dilakukan dapat disimpulkan bahwa terdapat perbedaan pengaruh latihan Obstacle Run terhadap peningkatan daya tahan Cardiovascular pada atlet Depok Trail Running Academy.
PENGARUH SENSORY PLAY BOX TERHADAP KEMAMPUAN MOTORIK HALUS ANAK
Authors: Ilmiyah Ramadhana Safira , Qori'ah Maria , Andriani Viena Wanidha 
Published: December 2024

Dapat dikatakan bahwa area pertumbuhan yang paling penting yang harus didorong adalah keterampilan motorik. Kemampuan untuk memegang pensil dengan benar, menggambar dan mengikuti garis adalah salah satunya. Tujuan dari penelitian ini adalah untuk menyelidiki, menggunakan metode empiris, bagaimana Sensory Play Box memengaruhi keterampilan motorik halus siswa berusia empat hingga lima tahun di TK Al Mubarok Sempu selama tahun ajaran 2023–2024. Menggunakan desain kuasi-eksperimental, metodologi penelitian kuantitatif digunakan. Dalam rentang usia 4-5 tahun, penelitian ini dilakukan di TK Al Mubarok Sempu. 44 siswa menjadi sampel saturasi yang digunakan dalam penelitian ini, dengan kelas A2 sebagai kelompok eksperimen dan kelas A1 sebagai kelompok kontrol. Pemantauan dan perekaman non-partisipan digunakan untuk memperoleh data. Uji prasyarat, uji homogenitas, uji normalitas, dan uji t berpasangan independen semuanya digunakan dalam teknik analisis data melalui interpretasi data menggunakan SPSS versi 26. Berdasarkan nilai signifikansi uji t berpasangan independen, yang digunakan sebagai alat analisis data dan menghasilkan temuan 0,001 < 0,05 setelah perlakuan, simpulan penelitian ditarik. Sebelum perlakuan, hasilnya adalah 0,647 > 0,05. Kita dapat menyimpulkan bahwa kotak permainan sensorik di TK Al Mubarok Sempu berdampak pada kemampuan motorik halus anak usia 4-5 tahun. Kata Kunci: Anak Usia Dini, Sensory Play Box, Motorik Halus