bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloidderived peripheral blood suppressor cells at haematopoietic stem cell mobilisation in multiple myeloma patients
Authors: Aristova T. A. , Batorov E. V. , Sergeevicheva V. V. , Sizikova S. A. , Ushakova G. Yu. , Gilevich A. V. , Shevela E. Ya. , Ostanin A. A. , Chernykh E. R. 
Published: September 2021

Introduction. Multiple myeloma (MM) is a B-cell malignancy with clonal expansion of plasma cells in bone marrow. Highdose chemotherapy with autologous haematopoietic stem cell transplantation is among main consolidation therapies in MM. Myeloid-derived suppressor cells (MDSCs) are immature myeloid-accompanying cells able to suppress the immune response. The administration of granulocyte colony stimulating factor (G-CSF) to mobilise haematopoietic stem cells (HSCs) increases the MDSC count in peripheral blood (PB).Aim — to study MDSC subsets in PB of remission MM patients and their incidence dynamics at HSC mobilisation.Methods. The study surveyed 35 MM patients prior to and after HSC mobilisation. The counts of granulocytic (G-MDSCs; Lin–HLA-DR–CD33+ CD66b+), monocytic (М-MDSCs; CD14+ HLA-DRlow/–) and early MDSCs (E-MDSCs; Lin–HLA-DR– CD33+ CD66b–) were estimated in flow cytometry.Results. Remission MM patients differed from healthy donors in higher relative counts of G-MDSCs (Lin–HLA-DR– CD33+ CD66b+) and increased relative and absolute counts of М-MDSCs (CD14+ HLA-DRlow/–). М-MDSCs significantly outnumbered G-MDSCs. MDSC subset counts were elevated in complete response (CR) and very good partial response (VGPR), as well as in partial response (PR). Higher relative MDSC counts were associated with greater pretreatment (2–3 lines of chemotherapy). After HSC mobilisation with cyclophosphamide 2–4 g/m2 + G-CSF (filgrastim 5 μg/kg/day), the median relative E-MDSC and M-MDSC counts increased by 2.3 and 2.0 times, respectively, while the relative G-MDSC count raised 46-fold perturbing the MDSC subset balance.Conclusion. Remission MM patients had the increased relative G-MDSC and both relative and absolute M-MDSC counts compared to donors. A greater patient pretreatment was associated with higher relative G-MDSC counts. Treatment response (CR/VGPR vs. PR) was not coupled with MDSC count variation. The G-CSF-induced HSC mobilisation entailed a significant expansion of all three MDSC subsets in PB.
The frequency of detection of anti-HBc in blood donors from four regions of Russia
Authors: Abakarov R. R. , Tikhomirov D. S. , Tupoleva T. A. , Ignatova E. N. , Kulikov S. M. , Garmaeva T. Ts. , Tkachenko L. L. , Seitibragimov F. I. , Gilmutdinov R. G. , Mostovaya N. A. , Makedonskaya O. G. , Romashkina T. V. , Davydova L. E. , Gerasimova V. V. , Gaponova T. V. 
Published: September 2021

Introduction. Occult hepatitis B virus (HBV) revelation in HBV nuclear antigen testing is of particular importance to prevent transfusion infection.Aim — the identification of factors affecting the anti-HBc detection rate in donated transfusable blood components from different regions of Russia.Materials and methods. A cohort screening single-stage epidemiological study was conducted with 2,000 donor blood samples, 500 samples per each of four regions of the country, the Republics of Crimea (Simferopol) and Sakha (Yakutia), the cities of Saransk and Orenburg. Data on 968 blood samples from the National Research Center for Hematology’s donor bank were used as reference. The testing targeted HBV nuclear antigen antibodies. Positive donated blood samples were additionally tested for IgM and virus surface antigen antibodies using Abbott and Vector-Best commercial reagent kits.Results. Donor demographic profiles differed insignificantly across members of the Russian Federation. Males predominated among the donors (69.6 %). Anti-HBc was detected in 219 of 2,000 samples examined (10.9 %). The donor blood sample anti-HBc detection rate ranged from 6.0 to 21.6 %, depending on the region. Anti-HBc-positive proportions in Orenburg, Crimea, Mordovia and Sakha comprised 8.2, 8.0, 6.0 and 21.6 %, respectively (p < 0.01). First-time donors had anti-HBc in 8.06, regular donors — in 11.29 % cases. The anti-HBc detection rate varied with donor’s age, being zero or near 1 % in 20-yo or younger people. Acute HBV antibodies had zero rate in Orenburg at zero or low-titre (< 100 mIU/mL) protective antibodies; 31 total samples, 15 low-titre and 16 negative for protective antibodies. In Simferopol, acute phase antibodies were negative in 7 blood samples containing high-titre protective antibodies (> 100 mIU/mL) and in 5.0 % samples with their low or zero levels. In Yakutian donors, acute phase antibodies were revealed only at protective antibodies negative. In Saransk, this marker was equal-proportion at zero and high-titre protective antibodies (3.3 % each).Conclusion. Transfusion component procurement from younger donors should be prioritised as enhancing haemotransfusion viral safety. Positive occult HBV tests were less common in regions with low HBV incidence.
National clinical recommendations for the diagnosis and treatment of mastocytosis
Authors: Melikyan A. L. , Subortseva I. N. , Shuvaev V. A. , Morozova E. V. , Lukina K. A. , Artemieva S. I. , Livov A. N. , Baykov V. V. , Vinogradova O. Yu. , Galstyan G. M. , Gilyazitdinova E. A. , Dvirnyk V. N. , Zhukova O. V. , Kovrigina A. M. , Kohno A. V. , Kuzmina L. A. , Lomaia E. G. , Lukina E. A. , Martynkevich I. S. , Mitina T. A. , Potekaev N. N. , Sudarikov A. B. , Shatokhina E. A. , Frigo N. V. , Savchenko V. G. 
Published: September 2021

Introduction. Recommendations cover the current state of diagnosis and treatment of mastocytosis.Aim — а consolidation of the Russian experts’ opinion on treatment for adult mastocytosis.Main findings. The recommendations have been developed taking into account foreign literature, national experience and world clinical evidence on therapy for systemic and cutaneous mastocytoses, mast cell leukaemia and other mastocytosis forms. The significance of bone marrow and peripheral blood molecular genetic testing for the presence of KITD816V gene variants is demonstrated. The treatment regimens described are based on midostaurin, imatinib, cladribine, hydroxycarbamide, interferon alfa and haematopoietic stem cell transplantation. Prognosis in different forms of mastocytosis is provided.
Quality Assurance in Nigeria’s Education System: Prospect and Challenges
Authors: Usman Yunusa Dangara , Chinyere Madudili Geraldine 
Published: September 2021

The study was conducted with the aim of establishing the relevance and challenges affecting quality assurance in Nigerian education system. Secondary data analysis methodology was adopted for the study. To easily achieve the objectives, the concept of quality assurance, strategies for building quality assurance into the education system and parameters for measuring quality assurance and challenges were discussed. The study identified some challenges affecting quality assurance to include shortage of funds, insecurity, policy inconsistency, and lack of regular training of staff etc. The paper concludes that since the essence of education is to make an individual useful quality assurance strategies should be monitored and evaluated on regular basis in order to improve the quality of the educational system in Nigeria. The study therefore recommends amongst others improved funding of the education sector, regular training and retraining of staff and provision of adequate security for learning environment in the country as a way forward.
Gobierno de Gabinete
Authors: Portillo Arévalo Melvin Giovanni 
Published: September 2021

OBJETIVO: presentar un análisis crítico con la finalidad de realizar conclusiones, aportes y criterios del libro “El Gobierno de Gabinete” del jurista Diego Valadez, que tiende a explicar la propuestas del nuevo sistema de gobierno que se propone para México. MÉTODO: el método utilizado fue selectivo debido a que se seleccionó la bibliografía a estudiar, correspondiente al tema “Gobierno de Gabinete” del del autor constitucionalista Diego Valadez. RESULTADOS: la reforma del Estado, especialmente de las libertades y responsabilidades de quienes nos gobiernan, así como entender que una democracia no sólo son derechos de los ciudadanos y libertades políticas sino que también debe existir una responsabilidad de los gobernantes, considero que son aspectos relevantes del tema. CONCLUSIÓN: es una etapa que se está refiriendo a los gobernantes y no sólo a los gobernados, ya que ahora no sólo se habla del derecho de elegir a nuestras autoridades sino que también cómo podemos pedirle a los gobernantes algún tipo de respuestas cuando incurren en contra de una norma constitucional o contra los intereses generales y el bien común. Para lo anterior, es necesario un análisis de los representantes del pueblo, construyendo nuevas instituciones que permitan que los electores puedan ratificar el voto con dignidad y eficacia; pero también poder negarlo cuando esa representación no responde a los intereses del pueblo.
Conceptions des enseignants du fondamental I dans le traitement des Situations-problèmes de proportionnalité
Authors: Alpha Ousmane , Almouloud Saddo Ag 
Published: September 2021

RÉSUMÉ
Le présent article est tiré de nos travaux de thèse portant sur l’écologie et la proportionnalité dans l’enseignement fondamental au Mali de 1960 à nos jours. Notre problématique est centrée d’une part sur la persistance de la technique de la règle de trois malgré les différentes évolutions du curriculum prescrit de 1960 à nos jours au Mali et d’autre part sur les conceptions que les enseignants entretiennent avec la notion. À travers l’analyse des productions des enseignants soumis à un questionnaire, nous constatons que la règle de trois reste le modèle dominant dans le traitement de la proportionnalité et que les conceptions des enseignants influent beaucoup sur les comportements des élèves face à un problème de proportionnalité. En effet de 1960 à nos jours, nos résultats révèlent que la règle de trois a joué un rôle prépondérant dans le traitement des problèmes de proportions et de proportionnalité. Notre étude a révélé que cette restriction de la vie de la proportionnalité au détriment des règles qui rattachent les situations de proportionnalité au concept de référence la fonction linéaire est en grande partie liée à la conception que les enseignants de terrain (aussi acteurs de la noosphère) se font de la proportionnalité.
The EVAL framework: Developing impact evaluation scholars
Authors: Strong Robert , Dooley Kim , Murphrey Theresa , Strong Jen , Elbert Chanda , Baker Matt 
Published: September 2021

The complexities of food, agriculture, natural resources, and human sciences (FANH) programs and projects require faculty to write and secure funding in addition to mastering skills such as evaluation competencies that integrate abilities in quantitative and qualitative research methods and evaluation theory and practice. The EVAL Framework was developed to advance skill development among FANH graduates to include these competencies and increase the pipeline of students who have the essential skills needed to advance FANH initiatives and priorities. The EVAL Framework includes four primary constructs: (a) Evaluation, (b) Value, (c) Active and Experiential Learning, and (d) Leadership. The purpose of EVAL is to build relationships with untapped FANH fields to develop a pipeline for graduates to become evaluation leaders for advancing food and agricultural sciences. This experiential learning and development model focuses on foundational and enrichment experiences, through formal coursework, project-based learning, and contextually rich environments. Mentoring, individualized development plans, scholarly learning communities, collaboration, transferable skills, and career planning and guidance activities are integrated into the EVAL framework to enhance skill development among EVAL scholars.
Morphological and morphometric changes and epithelial apoptosis are induced in the rat epididymis by long-term letrozole treatment
Authors: Pilutin Anna , Misiakiewicz-Has Kamila , Rzeszotek Sylwia , Wiszniewska Barbara 
Published: September 2021

The epididymis is an organ that plays a key role in sperm maturation. The aim of this study was to examine the association between the chronic treatment of mature male rats with letrozole and morphological evaluation and morphometric values of epididymis as well as changes in the number of apoptotic cells in epididymal epithelium. Adult rats were treated with letrozole for 6 months and the epididymis weight, morphology, morphometric values and the number of apoptotic cells in the epithelium were examined. Long-term aromatase inhibition resulted in presence of intraepithelial clear vacuoles, hyperplasia of clear cells and a hyperplastic alteration in the epithelium known as a cribriform change. Moreover, changes in diameters of the epididymal duct and the epididymal lumen and changes in the epididymal epithelium height were observed. The number of apoptotic epithelial cells was increased in letrozole-treated group. It can be indicated that chronic treatment with letrozole can affect morphology, morphometric values and apoptosis in the epididymis of adult male rats. Observed changes are similar to that observed in the aging processes and may also be important for patients treated with aromatase inhibitors.
Secondary School Socioeconomic Status and Athletic Training Practice Characteristics
Authors: Robison Hannah J. , Simon Janet E. , Nelson Erik J. , Morris Sarah N. , Wasserman Erin B. , Docherty Carrie L. 
Published: September 2021

Context
Socioeconomic status (SES) is a significant predictor of morbidity and mortality across health outcomes. Limited information exists on how school SES affects athletic training practice when a certified athletic trainer (AT) is present at secondary schools.

Objective
To describe contact frequencies and service rates provided by ATs for injuries among secondary school student-athletes and how these differ by school SES.

Design
Cross-sectional study.

Setting
The number of athletic training facility (ATF) visit days and AT services were collected from 77 secondary schools. Schools were separated into 3 school SES groups: affluent (n = 31), average (n = 29), and disadvantaged (n = 17).

Patients or Other Participants
Secondary school student-athletes who participated in ≥1 of 12 boys' or 11 girls' sports, visited the ATF during the 2014–2015 through 2018–2019 academic years, and received athletic or nonathletic injury care.

Main Outcome Measure(s)
Contact frequencies were expressed as ATF visit days per injury, AT services per injury, and AT services per ATF visit day. Rates for service type used were expressed as the total count over reported athlete-exposures.

Results
The ATs documented 1191 services. Affluent and average SES school communities provided more contact frequencies for injury-related care than did disadvantaged school communities, particularly in AT services per injury (7.10 ± 13.08 versus average: 9.30 ± 11.60 and affluent: 9.40 ± 12.20; P = .020). Affluent school communities supplied greater rates of services in 5 of the 11 service groups reported. No differences were observed among school SES groups in therapeutic exercise.

Conclusions
Our findings reflect that AT practice characteristics may have differed by school SES, but these differences did not appear to result in less medical care. Given the complexity and widespread effects of SES, future investigators should use a complex method to determine SES and aim to identify how SES may affect secondary school student-athletes in ways other than AT practice characteristics.
Análisis de la participación del café en las exportaciones agropecuarias en el Ecuador periodo 2015-2019
Authors: Cacao Damaris Adelaida Banchón , Campoverde Jessica Maribel Quezada , Carpio Eveligh Prado , Unda Salomón Barrezueta 
Published: September 2021

En el Ecuador la producción de café cumple un papel importante en la economía del país, siendo destacada a lo largo de los años, ya que es una de las fuentes importantes que genera empleo y divisas, por lo tanto, la presente investigación se desarrolló en Ecuador, que se encuentra ubicado en América del Sur, y tiene como objetivo “analizar la participación del café en las exportaciones agropecuarias del Ecuador en el periodo 2015-219”, mediante un enfoque descriptivo, de corte transversal y no experimental cuyo diseño es de tipo exploratorio, donde se evaluaron las cifras históricas del Sistema de Información y Producción Agropecuaria. Los resultados revelaron que la producción de café en Ecuador ha mantenido una tendencia decreciente en el periodo evaluado por diferentes causas como; las malas condiciones de las plantaciones por la afectación de la roya, precio del producto, tecnificación, factores climáticos, costos, escasez en mano de obra, vías de comunicación, y déficit en demanda del producto.

In Ecuador, coffee production plays an important role in the country's economy, standing out over the years, since it is one of the important sources that generates employment and foreign exchange, therefore, this research was developed in Ecuador, which It is located in South America. , and aims to "analyze the participation of coffee in agricultural exports from Ecuador in the period 2015-219", through a descriptive, cross-sectional and non-experimental approach whose design is exploratory, where the historical figures of the Information Agricultural and production system was evaluated. The results revealed that coffee production in Ecuador has maintained a decreasing trend in the period evaluated for different causes such as; the poor conditions of the plantations due to the impact of rust, product price, modernization, climatic factors, costs, labor shortage, communication routes and deficit in product demand.
Evaluación espacial del comportamiento fenológico de la vegetación mediante imágenes satelitales distrito de chiara-ayacucho 2000-2015
Authors: Rodríguez Jorge Luis Lozano , Fun Juan Carlos Chang Chang , Cruz Oscar Enrique Tang , Angeles Milagros Rocio Menacho , Gutiérrez Hernán Oscar Cortez , Gutiérrez Milton Milciades Cortez 
Published: September 2021

La presente investigación se realizó el análisis de las imágenes satelitales MODIS-Terra 250m x 250m de resolución espacial y determinar el comportamiento fenológico de la cobertura vegetal del distrito de Chiara. El objetivo de esta investigación es dar a conocer y demostrar la importancia de la metodología utilizada (imágenes de satélite MOD13Q1) para el análisis multitemporal de la vegetación, mediante el uso del software ENVI, IDL, ArcGIS. En este sentido, se ha logrado describir el comportamiento de la vegetación en el periodo de los dieciséis años, y determinar una variabilidad del área de vegetación en las estaciones anuales de verano, otoño, invierno y primavera y estimar mediante métodos estadísticos la variabilidad del NDVI. Los principales resultados obtenidos son: La variación fenológicos de los ecosistemas, según la estacionalidad climática de las áreas estudiadas. En este sentido, los cambios y variaciones son explicados en base a las características de pixeles de colores. Los resultados obtenidos pueden servir como insumo para mejorar el proceso y clasificación de las imágenes de satélite con el objeto de elaborar mapas temáticos y contribuir a la mejor toma de decisiones en cuanto al uso adecuado de los calendarios agrícolas definidos para cultivos anuales y/o transitorios instalados en dicho distrito.

The present research was the analysis of the satellite imagery MODIS-Terra 250m x 250m of spatial resolution and determine the phenological behavior of the vegetation cover of the district of Chiara. The objective of this research is to make known and demonstrate the importance of the methodology used (satellite images MOD13Q1) for multitemporal analysis of vegetation, using the software ENVI, IDL, ArcGIS. In this sense, it has been possible to describe the behavior of vegetation in the sixteen-year period, and to determine a variability of the vegetation area in the annual seasons of summer, autumn, winter and spring and to estimate by means of statistical methods the variability of NDVI. The main results obtained are the phenological variation of the ecosystems, according to the climatic seasonality of the studied areas. In this sense, changes and variations are explained based on the characteristics of colored pixels. The results obtained can serve as input to improve the processing and classification of satellite images in order to produce thematic maps and contribute to better decision making regarding the proper use of the defined agricultural calendars for annual and / or transient crops Installed in that district.
Componentes del sector pirotécnico para alcanzar la innovación
Authors: Pérez Castañeda Suly Sendy , Espinoza Martínez Gisela Janeth , Feregrino Feregrino Jorge 
Published: September 2021

El objetivo de esta investigación es determinar los componentes de innovación del sector pirotécnico. La metodología de investigación tiene un enfoque cualitativo, por su alcance exploratorio, por la manipulación de las variables no experimental, por la temporalización del fenómeno, transversal y por el lugar donde se realiza, de campo. La población fueron los productores pirotécnicos del Municipio de Tultepec, Estado de México, mismos que se abordaron de forma aleatoria. El muestreo fue no probabilístico a conveniencia del investigador, tomándose 204 productores pirotécnicos. El objeto de estudio son los polvorines de Tultepec, Estado de México.
Abstract The objective of this research is to determine the innovation components of the pyrotechnics sector. The research methodology has a qualitative approach, by its exploratory scope, by the manipulation of non-experimental variables, by the temporalization of the phenomenon, transversal and by the place where it is performed, field. The population were the pyrotechnic producers of the Municipality of Tultepec, Estado de Mexico, which were addressed randomly. Sampling was not probabilistic at the investor's convenience, with 204 pyrotechnic producers taking over. The object of study is the powders of Tultepec, Estado de Mexico.
PELATIHAN PROGRAM PENDAMPINGAN PESERTA DIDIK DI SMA KRISTEN CITRA BANGSA KUPANG DALAM MELAKSANAKAN PENBELAJARAN JARAK JAUH (PJJ)
Authors: Simanjuntak Junihot M. , Setio Agus , Lumban Toruan Arnes Dela , Zebua Febri Yanti , Nullik Simson 
Published: September 2021

Tujuan dari pengabdian ini adalah: 1) Untuk meninjau peranan guru dalam penyusunan perencanaan dan pelaksanaan pembelajaran jarak jauh agar berjalan dengan efektif dilapangan sesuai dengan perencanaan yang sudah disusun. 2) Memberikan pembelajaran jarak jauh yang diminati oleh peserta didik sesuai dengan pembelajaran yang telah terprogram. Bentuk kegiatan ini adalah pendampingan pembelajaran jarak jauh peserta didik SMA Kristen Citra Bangsa Kupang. Peserta kegiatan ini terdiri dari: 1) Guru-guru SMA Kristen Citra Bangsa Kupang, dan 2) Peserta didik kelas X, XI, dan XII. Kegiatan ini dilakukan dengan metode mengajar menggunakan video, ceramah, diskusi dan tanya jawab. Hasil kegiatan pendampingan adalah 1) terjadinya peningkatan kemampuan guru-guru SMA Kristen Citra Kupang dalam penyusunan program pembelajaran jarak jauh setelah diberikan pelatihan dan pendampingan; dan 2) terjadinya peningkatan keterampilan guru- guru SMA Kristen Citra Bangsa Kupang dalam mengimplementasikan pembelajaran jarak jauh setelah diberikan pendampingan.