bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Computed Tomographic Angiography after Abnormal Ischemia Test as a Gatekeeper to Invasive Coronary Angiography.
Authors: Reis João , Ramos Ruben , Marques Hugo , Daniel Pedro Modas , A Silvia , Morais Luis Almeida , Cruz Madalena , Moreira Rita , Monteiro André , Cacela Duarte , Figueiredo Luisa , Ferreira Rui Cruz 
Published: August 2021

Abstract
ObjectivesThis study aimed to determine the impact of systematic coronary computed tomographic angiography (CCTA) use following an abnormal non-invasive ischemia test (NIST) on patient selection strategy for invasive coronary angiography (ICA).BackgroundIn patients with suspected stable coronary artery disease (CAD), NIST use frequently results in sub-optimal diagnostic and revascularization yields of ICA.MethodsThis randomized clinical trial, conducted at a single academic tertiary center, selected 220 symptomatic patients with mild-to-moderately abnormal NIST results who were referred for ICA. Patients received either the originally intended ICA (n = 105) or CCTA (n = 115). The primary endpoint was the diagnostic yield of ICA in each group. Revascularization yield and major adverse cardiovascular events at 12 months were also assessed.ResultsThe patients were 69 ± 9 years old, 60% were men, and 31% had typical angina. Mean pre-test probability of obstructive CAD was 34%. Overall prevalence of obstructive CAD was 37.7% on the index angiographic procedure. In the CCTA group, ICA was cancelled by referring physicians in 83 patients (72.2%) after receiving CCTA results. For those undergoing ICA, diagnostic (84.4% vs 41.7%, p < 0.001) and revascularization (71.9% vs 38.8%, p = 0.001) yields were significantly higher for CCTA-guided ICA than for standard NIST-guided ICA. Mean cumulative radiation exposure was significantly lower in the CCTA-guided ICA arm than in the NIST-guided ICA arm (12 ± 9 vs 16 ± 10 mSv, respectively, p = 0.024). There were no significant differences in the primary safety endpoint rates between the strategies (p = 0.439).ConclusionsIn patients with suspected CAD and mild-to-moderately abnormal ischemia tests, a diagnostic strategy including CCTA as a gatekeeper is safe and effective and significantly improves diagnostic and revascularization yields of ICA.
Differentiation Between Combined Hepatocellular Carcinoma and Hepatocellular Carcinoma: Comparison of Diagnostic Performance Between Ultrasomics-Based Model and CEUS LIRADS v2017
Authors: Li Chao-qun , Zheng Xin , Guo Huan-ling , Cheng Mei-qing , Huang Yang , Xie Xiao-yan , Lu Ming-de , Kuang Ming , Wang Wei , Chen Li-da 
Published: August 2021

Abstract
Background.
The imaging findings of combined hepatocellular cholangiocarcinoma (CHC) may be similar to hepatocellular carcinoma (HCC). CEUS LI-RADS may not perform well in distinguishing CHC from HCC. Studies have shown that Radiomics has an excellent ability of imaging analysis. This study was to establish and confirm an ultrasomics model for differentiating CHC from HCC.
Methods.
Between 2004 and 2016, we retrospectively identified 53 eligible CHC patients and included 106 eligible HCC with a ratio of HCC : CHC = 2 : 1 randomly, all of which were categorized according to Contrast-Enhanced (CE) ultrasonography (US) Liver Imaging Reporting and Data System (LI-RADS) version 2017. The model based on ultrasomics features of CE US was developed in 74 HCC and 37 CHC, confirmed in 32 HCC and 16 CHC. The diagnostic performance of LI-RADS or ultrasomics model was assessed by the area under the curve (AUC), accuracy, sensitivity and specificity.
Results.
In entire and validation cohort, 62.3% and 78.1% of HCC were correctly assigned to LR-5, 73.6% and 87.5% of CHC were assigned to LR-M correctly. Up to 27.4% of HCC and 26.4% of CHC were misclassified by CE US LI-RADS. 97.2% and 90.6% of HCC as well as 94.3% and 87.5% of CHC correctly diagnosed by the ultrasomics model in entire and validation cohort respectively. The AUC, accuracy, sensitivity, and specificity of ultrasomics model were significant improved compared with CE US LI-RADS in entire cohort ( all P < 0.05), but there was no significant difference in validation cohort.
Conclusion.
The proposed ultrasomics model had an ability similar to CE US LI-RADS v2017 for differentiating CHC from HCC, which may be more helpful to differentiate CHC from HCC in clinical diagnosis.
Trends in Hysteroscopic Endometrial Sampling in Women 70 Years and Older
Authors: Bar-On Shikma , Solomon Neta , Rattan Gilad , David Alon Ben- , Grisaru Dan 
Published: August 2021

Abstract
Background: Women 70 years of age or older with suspected endometrial pathologies would especially benefit from office hysteroscopy due to the risks of anesthesia and high rates of clinically significant findings in this age group. However, performing office hysteroscopy in those older patients can be technically challenging, and patient cooperation, which is essential for the success of the office procedure, may be compromised in this age group. The objective of the present study was to characterize the clinical and procedural features of office and operating-room hysteroscopy in women 70 years of age or older.Methods: This was a retrospective chart analysis of all women aged 70 years and older who underwent a hysteroscopy procedure in a single tertiary-care medical center between March 2011 and August 2018. We compared the clinical and procedural characteristics of patients who underwent hysteroscopy in our outpatient clinic to those who underwent hysteroscopy under anesthesia in the operating room. Primary outcomes included procedure success and histopathological findings. Secondary outcomes included short-term complications of the procedure. Results: The data of 577 patients were analyzed. The median age at the time of the procedure was 76 years. 225 office hysteroscopy procedures and 405 operating room procedures were included. Of the 236 patients with postmenopausal bleeding (PMB), 73 (30.9%) were diagnosed with having malignancy compared to 25/341 (7.3%) patients with no PMB (p < .001, odds ratio (OR) = 5.66; confidence interval (CI) 3.46-9.26). The office procedure was successful in 194 (87%) patients. Fifty-three patients required a second hysteroscopy, which revealed 12 cases of premalignant or malignant lesions. The volume of procedures in the office increased 16 times during the study period, and the diagnostic yield of new abnormal findings by means of the procedure in the office setting has increased over time. Operating room hysteroscopy had a higher rate of complications compared to office hysteroscopy, including mortalities related to the procedure.Conclusions: Office hysteroscopy for women over the age of 70 is safe, feasible, and reliable for diagnosis of endometrial malignancy. Failed hysteroscopy and a moderate-to-high index of suspicion for malignancy indicates the need for a repeat hysteroscopy.
The Use of Soft-Sediment Deformation Structures As Proxies For Paleoseismic Activity And Shaking: A Review
Authors: Zhong Ning , Jiang Hanchao , Li Haibing , Su Dechen , Xu Hongyan , Liang Lianji , Fan Jiawei 
Published: August 2021

Abstract
Quantifying the magnitude of an earthquake is very important for long-term and medium-term earthquake prediction, post-earthquake emergency rescue and seismic hazard assessment. Paleoseismology is the investigation of past earthquakes in the geological record, in particular their location, timing and size. Uncertainties remain in the paleoearthquake magnitudes determined by traditional surface rupture parameters, especially because most seismic events do not result in surface ruptures. In order to address the problem of magnitude evaluation of earthquakes that did not reveal major dislocations, this paper deals with the methods used to determine the seismic shaking intensity based on the types and forms of soft-sediment deformation structures, including maximum liquefaction distance, thickness of disturbed layer, empirical formulae, and thickness of rapidly deposited sand layer. Then we discuss and analyze these methods in terms of their theoretical basis, advantages and disadvantages, accuracy, applicability and problems. We chose two case studies: first, a typical seismics-related deposit (liquefied layer and dsirupted layer) represented by a seismite in the late-Pleistocene Lake Lisan section near Masada in the Dead Sea Basin; and second, the liquefied diapir triggered by an earthquake in the late-Quaternary lacustrine sediments at Luobozhai in the upper reaches of the Minjiang River, east Tibet. The six methods listed above are employed to determine earthquake magnitudes associated with the seismics-related deposit and liquefied diapir, yielding magnitudes of 5.5-6.5 and 6-7, respectively. The combination of the six methods, provided a new and relatively convenient method for determining seismic shaking, especially in lacustrine sediments. This study can serves as a valid reference for comparing methods of calculating the magnitude of a paleoearthquake based on surface rupture parameters, and provides a better understanding of the long-term seismic activity and risk in tectonically active regions.
Genetic Characterization of Rainfed Durum Wheat Genotypes Based On Functional Markers Associated With Grain Quality Proteins
Authors: Kheibary Zahra Moradi , Azizinezhad Reza , Mehrabi Ali Mehras , Khosrowshahli Mahmood , Etminan Alireza 
Published: August 2021

Abstract
Analysis of genetic diversity provides helpful information necessary to develop the breeding and conservation strategies of crops. In this study, the genetic diversity and population structure of 90 durum wheat genotypes maintained at Sararud Dryland Agricultural Research Institute, Kermanshah, Iran, were evaluated by using 23 gene-specific markers (functional markers, FMs) encoding high and low molecular weight glutenin and gliadin alleles. Results showed that 12 out of the 23 FMs used were polymorphic and amplified 52 polymorphic loci. Primer Ax2 ⃰ had the highest discriminatory power. The population structure analysis classified the durum wheat collection into four populations. On average, population 4, consisting of 8 genotypes, had the highest allele number as well as genetic variation. Analysis of molecular variance indicated that 82% of the total variation was distributed among populations. The diversity among populations and gene flow were 0.14 and 3.03, respectively. The Jaccard distance coefficient revealed that genetic dissimilarities ranged from 0.031 between G62 and G65 to 0.725 between G36 and G51. Neighbor-joining method clustered individuals into six main groups. Results showed a remarkable level of genetic diversity among studied durum wheat genotypes which can be of interest for future breeding programs.
Bifurcation Analysis in a Diffusion Mussel-Algae Interaction System with Delays Considering the Half-Saturation Constant
Authors: Jiang Zhichao , Zhang Weicong 
Published: August 2021

Abstract
In this paper, the kinetics of a class of delayed reaction-diffusion musselalgae system under Neumann boundary conditions with the half- saturation constant is studied. The global existence and priori bounds as well as the existence conditions of positive equilibrium are obtained. The half-saturation constant affect the stability of the system and may result in Turing instability. When the half-saturation constant exceeds a certain critical value, the boundary equilibrium is globally asymptotically stable which means that the larger half-saturation constant forces the mussel population toward extinction. By analyzing the distribution of the roots of the characteristic equation with two delays, the stability conditions of the positive equilibrium in the parameter space are obtained. The stability of the positive equilibrium can be changed by steady-state bifurcation, Hopf bifurcation, Hopf-Hopf bifurcation or Hopf-steady state bifurcation, which can be verified by some numerical simulations. Among parameters, the half-saturation constant and two delays drive the complexity of the system dynamics.
Regional Environmental Supervision And Corporate Environmental Investment: From The Perspective of Ecological Damage Compensation
Authors: Zeng Huixiang , Cheng Chen , Jin Youliang , Zhou Qiong 
Published: August 2021

Abstract
Based on the “Pilot Reform of the Compensation System for Ecological and Environmental Damage” launched in 2015 and a research sample of listed companies in China's heavy pollution industry from 2014 to 2017, this paper uses a difference-in-differences model to empirically test the impact of the compensation system on corporate environmental investment, as well as the moderating effect of market degree and firm ownership. The result shows that the implementation of the compensation system has significantly promoted corporate environmental investment, and the market degree has a moderating effect, but the supervision effect remains the same due to firm ownership. Local government’s strict environmental supervision on local enterprises is the important channel to ensure the function of ecological damage compensation system. This research provides a reference for the national government to formulate specific and effective environmental policies, stimulate the environmental governance motivation of local governments, and encourage enterprises to assume environmental responsibilities, to achieve green and sustainable development.
Geotechnical Properties Evaluation Utilizing Geological, Geomorphological and Shallow Geophysical Surveys of Wadi Habib Entrance Site, Eastern Desert, Egypt.
Authors: Omran Awad A.A. , El-Younsy Ahmed-Reda M. 
Published: August 2021

Abstract
An integrated approach is carried out in a proposed engineering site at Wadi Habib, Egypt. The study aimed to characterize the geological, geotechnical and hydrogeological environment evaluate their suitability for civil engineering constructions. The present study reveals that the area is mainly covered by the Eocene carbonate rocks uncomfortably overlain, in some areas, by the Oligocene gravels. The Pliocene mudstone and the Pleistocene/recent fine clastic deposits are recorded in the subdued ground. The surface and subsurface fractures around Wadi Habib area are mainly represented by high angle normal faults trending NNW- SSE, NW-SE, WNW-ESE and ENE-WSW. The morphometric analysis reveals that Wadi Habib is generally of seventh order, sinuous course, elongated, untainous and hilly, course topographic texture and high resistance and low permeable floor. A total of 32 seismic refraction profiles were conducted in two directions N 35° W and N 55° E. Three geoseismic layers of different lithological, compressional and shear velocities and elastic properties are achieved. The geotechnical parameters involving kinetic elastic moduli, soil material competence parameters and the bearing capacity are estimated and hence indicated the characteristics of the foundation materials for civil engineering constructions in the investigated site. Also, 30 VES’es are implemented and interpreted to test the geological and hydrogeological conditions. Subsurface geoelectrical layers are delineated and verified. The proposed site is characterized by a relatively low to moderate seismicity. The geotechnical parameters of geoseismic layers and the hydrogeological probable troublesome (cavities, fractures, faults) for building structure and soil suitability for foundation purposes are concluded
MicroRNAs in Serum Exosomes as Circulating Biomarkers for Postmenopausal Osteoporosis with Fragility Fractures
Authors: Shi Hongli , Jiang Xin , Xu Cuidi , Cheng Qun 
Published: August 2021

Abstract
Background

Postmenopausal osteoporosis (PMOP) brings a heavy burden to society and seriously affects the quality of life of elderly people. Circulating biomarkers based on miRNAs, especially exosomal miRNAs, are widely studied. However, miRNAs in serum exosomes have not yet been reported in PMOP. The present study aimed to investigate the differences in miRNA expression profiles in PMOP with fragility fractures to identify the key circulating miRNAs in serum exosomes and to validate these molecules as potential biomarkers.
Methods

Postmenopausal women with osteoporotic fracture (severe osteoporosis, SOP group) and normal bone mass (Ctrl group) were selected from community. Serum exosomes were isolated by traditional differential ultracentrifugation from participants. Isolated exosomes were identified by electron microscopy, western blotting and nanoparticle-tracking analysis and then examined for exosomal miRNAs sequencing. Target gene pathways enrichment of differently expressed miRNAs were performed by the online bioinformatics tools TargetScan and DAVID. Moreover, the function of miRNAs associating with bone mineral density (BMD) on bone turnover were further confirmed by transfecting these miRNAs into human bone marrow mesenchymal stem cells (hBMSCs) to detect ALP activities.
Results

Compared to control group, 170 miRNAs were found to be significantly upregulated and 69 miRNAs were downregulated in SOP group. Three miRNAs (miR-324-3p, miR-766-3p and miR-1247-5p) were found to be associated with BMD of L1-L4, FN and TH, while miR-330-5p and miR-3124-5p were associated with BMD of FN and TH. Target gene signaling pathways analysis of these five miRNAs showed that Wnt signaling pathway was the most enrichment pathway relating to bone metabolism. Furthermore, miR-330-5p was found to promote the ALP activity of hBMSCs, while mir-3124-5p showed the opposite result.
Conclusion

Serum exosomal miRNAs were differentially expressed in postmenopausal osteoporosis patients with fragility fractures. Our study provides the first evidence that exosomal miRNA profiling revealed aberrant circulating miRNA in postmenopausal osteoporosis. MiR-324-3p, miR-766-3p, miR-1247-5p, miR-330-5p and miR-3124-5p, which were associated with BMD, may serve as candidate biomarkers for the diagnosis of PMOP with fragility fractures and provide future research directions.
Secular Trends in Incidence and Mortality of Cervical Cancer in India and its States, 1990- 2019: Data from the Global Burden of Disease 2019 Study
Authors: Singh Mayank , Jha Ravi Prakash , Shri Neha , Bhattacharyya Krittika , Patel Priyanka , Dhamnetiya Deepak 
Published: August 2021

Abstract
Background: Cervical cancer is the fourth most common cancer that occurs to women worldwide. This study aims to assess trends in incidence and mortality of cervical cancer in India and its states over past three decades for tracking the progress of strategies for the prevention and control of cervical cancer. Methods: Data on cervical cancer incidence and mortality from 1990 to 2019 for India and its states were extracted from Global Burden of Disease study and were utilized for the analysis. Spatial and rank map has been used to see the changes in incidence and mortality of cervical cancer in different Indian states. Further, joinpoint regression analysis is applied to determine the magnitude of the time trends in the age standardized incidence and mortality rates of cervical cancer. We obtained the average annual percent change (AAPC) and corresponding 95% confidence intervals (CI) for each state. Results: Overall, from 1990 to 2019 Jharkhand (Incidence: -50.22%; Mortality: -56.16%) recorded the highest percentage decrement in cervical cancer incidence and mortality followed by the Himachal Pradesh (Incidence: -48.34%; Mortality: -53.37%). Tamilnadu (1st rank), Jammu & Kashmir and Ladakh (32nd rank) maintained the same rank over the period of three decade for age standardized cervical cancer incidence and mortality. The regression model showed a significant declining trend in India between 1990 and 2019 for age standardized incidence rate (AAPC: −0.82; 95%CI: −1.39 to −0.25; p < 0.05) with highest decline in the period 1998-2005 (AAPC: −3.22; 95%CI: −3.83 to −2.59; p < 0.05). Similarly, a significant declining trend was observed in the age standardized mortality rate of India between 1990 and 2019(AAPC: −1.35; 95%CI: −1.96 to −0.75; p < 0.05) with highest decline in the period 1998-2005 (AAPC: −3.52; 95%CI: −4.17 to −2.86; p < 0.05).Conclusion:Though the incidence and mortality of cervical cancer declined over past three decades but it is still a major public health problem in India. Information, education and communication activities for girls, boys, parents and community for the prevention and control of cervical cancer should be provided throughout the country.
The Impact of Bouxite Mining On The Semanduk Lake Environment: A Case Study In Tayan Hilir, Sanggau District, West Kalimantan Province, Indonesia Country
Authors: Purwanto Ajun , Andrasmoro Dony , Eviliyanto  
Published: August 2021

Abstract
Background: Several mining activities, especially bauxite, have been carried out in several areas in West Kalimantan. The areas most widely carried out bauxite mining are Sanggau and Ketapang districts. Bauxite mining is included in the classification of surface mining or often referred to as open mining. This is characterized by the demolition of the upper layers of soil and taking the results of weathering rocks, namely granite rocks. The demolition of topsoil is done with the clearing of vegetation above. In this condition, the land still has the same morphology when clearing has not been done and the soil has not been much disturbed. But after mining there is a lot of clay, sandstone, topsoil materials, of course, this will have a negative impact on the environment.Result: The results showed that the gradient of the slope has an important role in land conservation. The greater gradient of the slope will automatically increase the surface runoff, so the greater the energy of run-off. The soil depth is shallow on average and has poor deep soil drainage. Soil is easily eroded, so a lot of rocks and gravel are exposed on the surface, plants cannot develop properly. Floods often occur, in areas of alluvial plains with a range of more than 24 hours. The water availability capacity is also very low. Rainwater in the area mostly becomes runoff. The nutrient content in the ex-mining area is also low. Therefore it is necessary to improve efforts by means of reforestation of the former land so that in the future it can be used for certain uses, especially for agriculture, plantations, and forests.Conclusion: Slopes have an important role in land conservation. Slope affects runoff, effective soil depth, erosion rate, plant growth, waterlogging. Nutrient content in ex- Bauxite mining areas is also low.