bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulated molecular markers of restenosis and thrombosis by in-vitro vascular cells exposed to bioresorbable scaffolds
Authors: Vozzi F , Cecchettini A , Cabiati M , Mg Fornaro , Aretini P , Del Ry S , Rocchiccioli S , Pelosi G 
Published: May 2021

Abstract
Drug-eluting bioresorbable vascular scaffolds (BVSs) have emerged as a potential breakthrough for the treatment of coronary artery stenosis, providing mechanical support and drug delivery followed by complete resorption. Restenosis and thrombosis remain the primary limitations in clinical use. The study aimed to identify potential markers of restenosis and thrombosis analyzing the vascular wall cell transcriptomic profile modulation triggered by BVS at different values of shear stress (SS). Human coronary artery endothelial cells and smooth muscle cells were cultured under SS (1 and 20 dyne cm−2) for 6 h without and with application of BVS and everolimus 600 nM. Cell RNA-Seq and bioinformatics analysis identified modulated genes by direct comparison of SS conditions and Gene Ontology (GO). The results of different experimental conditions and GO analysis highlighted the modulation of specific genes as semaphorin 3E, mesenchyme homeobox 2, bone morphogenetic protein 4, (heme oxygenase 1) and selectin E, with different roles in pathological evolution of disease. Transcriptomic analysis of dynamic vascular cell cultures identifies candidate genes related to pro-restenotic and pro-thrombotic mechanisms in an in-vitro setting of BVS, which are not adequately contrasted by everolimus addition.
Carbon dot-based materials for wound healing applications
Authors: Ehtesabi Hamide , Nasri Reyhaneh 
Published: May 2021

Abstract
Skin repair is a complicated procedure in the human body. A proper clinical outcome cannot usually be provided by the present treatments to heal wounds. Reduction of infection, moisturisation of the wound, stimulation of the healing mechanisms, acceleration of the wound closure, and reduction of scar formation require more curative procedure. Nanomaterials are used in managing wound healing by representing an exclusive instrument with a specific design for close reflection of the physiologic procedures in injured tissues. Carbon dots (CDs) are tiny fluorescent carbon nanoparticles with a size range below 10 nm in diameter. Throughout the last few years, these nanomaterials have gained a rising ground because of their less toxicity, adjustable fluorescence, and physicochemical specifications. The wound healing field has witnessed a novel perspective owing to CDs-based therapies. This review summarises the state-of-the-art CDs-based wound healing applications and highlights their advantages over conventional wound healing methods. Following an introduction, the first section covers synthesise methods of CDs for wound healing application. Then, methods of wound treatment by using CDs were classified. After that, models to study the effect of CDs on wound healing have been studied. A final section covers the role of using CDs in wound healing. The conclusion summarises the current status and gives an outlook on potential future trends.
Electronic localization in small-angle twisted bilayer graphene
Authors: Hung Nguyen V , Paszko D , Lamparski M , Van Troeye B , Meunier V , Charlier J-C 
Published: May 2021

Abstract
Close to a magical angle, twisted bilayer graphene (TBLG) systems exhibit isolated flat electronic bands and, accordingly, strong electron localization. TBLGs have hence been ideal platforms to explore superconductivity, correlated insulating states, magnetism, and quantized anomalous Hall states in reduced dimension. Below a threshold twist angle (∼1.1∘), the TBLG superlattice undergoes lattice reconstruction, leading to a periodic moiré structure which presents a marked atomic corrugation. Using a tight-binding framework, this research demonstrates that superlattice reconstruction affects significantly the electronic structure of small-angle TBLGs. The first magic angle at ∼1.1∘ is found to be a critical case presenting globally maximized electron localization, thus separating reconstructed TBLGs into two classes with clearly distinct electronic properties. While low-energy Dirac fermions are still preserved at large twist angles

>

1.1
∘

, small-angle (

≲

1.1

°

) TBLG systems present common features such as large spatial variation and strong electron localization observed in unfavorable AA stacking regions. However, for small twist angles below 1.1∘, the relative contribution of the local AA regions is progressively reduced, thus precluding the emergence of further magic angles, in very good agreement with existing experimental evidence.
Full density graphite/copper-alloy matrix composite fabricated via hot powder forging for pantograph slide
Authors: Wang Man , Li Meng , Jiang Ke , Xu Enze , Liu Junwu , Zhong Honghai , Jiang Yang 
Published: May 2021

Abstract
High-performance copper-based pantograph slide materials play a crucial role in the rapid development of modern urban rail transit urgently. Herein, a full density graphite/copper-alloy matrix composite for pantograph slide has been successfully obtained by the hot powder forging process. The composite exhibits the full density when forging energy density is 307.6 J cm−3. In addition, the influence of different aging treatments on microstructure and mechanical performances of the composite has been studied in detail. The hardness and resistivity of the forged materials are greatly improved after an optimum aging treatment. Simultaneously, the friction and wear performances with or without currency current have been investigated, which demonstrates the friction coefficient can reach the minimum of 0.109 under 35 N. In current-carrying friction, the wear rate of the composite is an extremely small value of 5.5 × 10–5 mg m−1 after the aging treatment, indicating the outstanding anti-friction and self-lubricating performance. All the comprehensive analyses illustrate the full density graphite/copper-alloy matrix composite with excellent mechanical shows an enormous potential for pantograph slide.
Tetanus presenting as painful muscle spasms, dysphagia and delirium in an older adult
Authors: Merrick Minnie , Scarrott Ipshita 
Published: May 2021

Abstract
While tetanus is now a rare disease in the UK, it remains an important differential diagnosis for trismus and muscle spasms. Even more so in older adults, as this population is less likely to have received full vaccination. Hence, the highest incidence of tetanus in England is seen in older adults. Written informed consent for publication of their clinical details was obtained from the patient proxy.
A - 03 Concussion Symptom Reporting in Sport-Related Concussions During The COVID-19 Pandemic
Authors: SC Bunt , C Presley , T Tarkenton , K Wilmoth , N Didehbani , M Stokes , SM Miller , K Bell , H Batjer , CM Cullum 
Published: May 2021

Abstract

Objective
Evaluation of concussion symptoms is a key element in management of sport-related concussions (SRC). The COVID-19 pandemic has been linked to increased reports of anxiety and depression in the general population, though it is unknown if this increase has also affected reporting of concussion symptoms. The purpose of this study was to determine whether there were differences in reporting of concussion symptoms in adolescents who sustained an SRC before versus during the COVID-19 pandemic.

Methods
Subjects (n = 707) aged 12–18 with SRC were evaluated within 14 days of injury (M = 5.64 days, SD = 3.68) at a North Texas Concussion Registry (ConTex) clinic and completed the Sport Concussion Assessment Tool-5 (SCAT-5) Symptom Evaluation. Subjects were grouped by those evaluated before (n = 625) or after (n = 82) March 23, 2020 and were similar in age, sex, and history of treatment for anxiety or depression. T-tests were used to compare the number of endorsed concussion symptoms and symptom severity between groups.

Results
There was no significant difference in number of concussion symptoms endorsed (M = 10.81, SD = 6.53 vs M = 11.35, SD = 6.25, p = 0.463) or symptom severity (M = 28.33, SD = 24.14, M = 26.79, SD = 20.91, p = 0.540) between before vs during COVID-19 SRC groups.

Conclusions
In this cohort of young athletes, results suggest that despite effects of the COVID-19 epidemic on community mental health, we did not see evidence of a systematic influence on SRC symptom reporting during the pandemic.
A - 16 Sideline Athlete Study: An Examination of the Predictability of Concussion from a Computerized Neuropsychological Battery
Authors: B Makwana , C Faure , X Xu 
Published: May 2021

Abstract

Objective
The purpose of the study was to investigate the predictability of concussion diagnosis from four neurocognitive modules collected on the sidelines in high school athletes. We hypothesized that each neuropsychological module would be a positive significant predictor of the diagnostic outcome.

Methods
The study sample included 64 14- to 19-year-old athletes from four high schools in the southeastern Idaho region. Thirty athletes were diagnosed with a concussion and 34 athletes were not diagnosed with a concussion. The athletes were 75% male (N = 48) and 25% female athletes (N = 16). The athletes completed C3Logix (Comprehensive Concussion Management System), a computerized neuropsychological battery, as part of their baseline examination. If the athlete was suspected of sustaining a head injury, a modified C3Logix battery was administered same day which included the Graded Symptom Checklist (GSC), Trailing Making Test B (TMT B), Simple Reaction Time (SRT), and Choice Reaction Time (CRT) modules.

Results
Results showed that the GSC (M = 19.25, SD = 16.6, p &lt; 0.001), SRT (M = 314.14, SD = 45.02, p &lt; 0.05), and CRT (M = 417.45, SD = 72.46, p &lt; 0.001) postinjury scores and the GSC (13.88 SD = 15.80, p &lt; 0.001), SRT (M = 23.06, SD = 41.35, p &lt; 0.01), and CRT (M = 1.98, SD = 63.37, p &lt; 0.05) change scores were each respectively positive significant predictors of concussion diagnosis. TMT B postinjury (M = 49.44, SD = 13.94, p = 0.08) and change score (M = 0.48, SD = 13.46, p = 0.12) were not significant predictors of concussion diagnosis.

Conclusions
The clinically significant findings demonstrate that these short computerized neuropsychological tests are able to detect subtle changes following a concussion. Further research is needed to continue to demonstrate the role of computerized neuropsychological tests on the sideline.
A - 17 Fear of Falling in Older Adults with mTBI
Authors: LM Manderino , A Kissinger-Knox , A Colorito , A Mucha , A Puskar , MW Collins , AP Kontos , N Sherry 
Published: May 2021

Abstract

Objective
To evaluate the use of an assessment of fear of falling (i.e., Short Fall Efficacy Scale [SFES]) in the evaluation and management of mild traumatic brain injury (mTBI) in older adults.

Methods
Fifty-two older adults (40% male) aged 60–76 (66.44 ± 4.74) years were included in the study; 27 older adults diagnosed with mTBI within three months of injury (33.07 ± 18.86 days) and 25 age-group and sex-matched controls. All participants completed the SFES, Vestibular/Ocular-Motor Screening (VOMS), Post-Concussion Symptom Scale (PCSS), Generalized Anxiety Disorder- 7 Item (GAD-7), and Geriatric Depression Scale- 5 Item (GDS5). Statistical comparisons were performed using paired t-tests and Pearson correlations.

Results
There were no significant differences on demographic factors, with the exception of participants in the mTBI group being more likely to have a history of a sleep disorder (χ2 = 10.26, p = 0.001). T-tests revealed higher concern for falling on SFES and higher total symptoms on the VOMS, GAD-7, and PCSS (p &lt; 0.01) in mTBI versus controls. Those with mTBI who sustained a fall, compared to other mechanisms of injury, did not differ in their report of fear of falling post-injury (p = 0.74). SFES scores were moderately correlated with VOMS total score (r = 0.40, p &lt; 0.01), PCSS total score (r = 0.64, p &lt; 0.01), GAD-7 (r = 0.65, p &lt; 0.01), and GDS-5 (r = 0.60, p &lt; 0.05).

Conclusions
Older adults with mTBI endorse greater fear of falling on the SFES and more symptoms on mTBI assessment tools relative to healthy controls. Future studies should include objective measures of balance to evaluate the relationship between fear of falling and postural stability.
A - 18 Parent-Ratings of Patient Depressive Symptoms Are Predictive of Concussion Care Outcomes in a Pediatric Sample
Authors: LM Manderino , A Trbovich , H Bitzer , B Gillie , AP Kontos 
Published: May 2021

Abstract

Objective
The present study aims to examine how parental perception and child self-perception of depressive symptoms influence key clinical outcomes post-concussion, including symptom burden, treatment time, and treatment retention.

Methods
Participants 10–18 years (14.3 ± 2.2, 44.3% female, 3.8% history of depression) were recruited from a specialty clinic within 30 days of concussion (n = 106). The Mood and Feelings Questionnaire-Short (MFQ) Parent and Child versions and the Post-concussion Symptom Scale (PCSS) were completed at initial (Time 1) and second (Time 2) visits. Scores ≥8 indicate clinically significant depression on the MFQ, producing child-rated depression (CRD) and parent-rated depression (PRD) scores. Time in treatment was calculated as days between initial and clearance visits.

Results
Results of linear regression demonstrated higher PRD predicted longer treatment, B = 0.21, t(103) = 2.07, p &lt; 0.05. CRD was not predictive of treatment time, B = -0.0, t(103) = −0.1, p = 0.99. Another regression using Time 2 PCSS score as the outcome demonstrated that CRD at Time 1 predicted PCSS score at Time 2, B = 0.29, t(94) = 2.85, p &lt; 0.01, while PRD did not, B = 0.14, t(94) = 1.41, p = 0.16. Results of a logistic regression predicting return for formal clearance indicated that higher PRD predicted increased likelihood of being lost to follow-up, B = 0.21, p &lt; 0.05, 95% CI = 1.05–1.44.

Conclusions
Patients whose parents perceived them as being more depressed were in treatment longer and were less likely to be formally cleared after concussion. However, child rated depression at initial visit was more useful in predicting concussion symptom burden at follow up. Future research should further investigate how parental perceptions may influence pediatric concussion recovery.
A - 25 Screening for Anxiety and Depression Symptoms using the Post-Concussive Symptom Scale Among Varsity Athletes
Authors: SD Roberts , C Champigny , S Feldman , DB Flora , M Wojtowicz 
Published: May 2021

Abstract

Objective
Symptoms of anxiety and depression are prevalent among athletes and often overlap with symptoms of a concussion. Clinical screeners of anxiety and depression are infrequently used by athletic teams despite the relationship between affective symptoms and protracted post-concussion recovery. The study objective was to examine associations between individual symptoms on the post-concussive symptom scale (PCSS) and gold standard measures of anxiety and depression.

Methods
Pre-season baseline data was collected for 296 varsity athletes from York University, Toronto. Participants were between the ages of 17 and 25 (M = 20.01 yrs, SD = 1.69 yrs; 52% male). The PCSS from the SCAT-5 was used to assess baseline symptoms. Generali.

Results
Moderate to strong correlations were noted between specific items of the PCSS and the GAD-7 and PHQ-9. Feeling anxious (r = 0.55), concentration problems (r = 0.40), irritability (r = 0.39), trouble falling asleep (r = 0.38), fatigue (r = 0.36), and mental fog (r = 0.35) were the highest correlations with the GAD-7 (ps &lt; 0.001). Trouble falling asleep (r = 0.46), fatigue (r = 0.44), concentration problems (r = 0.41), memory problems (r = 0.37), feeling slowed down (r = 0.36), anxious (r = 0.36), and irritability (r = 0.36) were the highest correlations with the PHQ-9 (ps &lt; 0.001).

Conclusions
These findings allow for better delineation of symptoms of the PCSS that aid in identification of athletes with symptoms of anxiety or depression, who may be at risk for endorsing persistent symptoms following a concussion.
Electrocardiographic markers of incident atrial fibrillation in patients with cryptogenic stroke
Authors: Couto Pereira S , Silverio Antonio P , Valente Silva B , Brito J , Rodrigues T , Alves Da Silva P , Veiga A , Ferro J , Pinto FJ , Fonseca C , Almeida AG 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Prolonged screening of AF in patients (pts) with cryptogenic stroke (CS) is recommended and electrocardiographic markers of atrial remodeling, like p-wave dispersion, have been described in literature. Electrocardiographic changes in pts with CS to predict AF in the follow up are not well-established.

Purpose
To identify ECG predictors of AF in a subset of pts with cryptogenic stroke.

Methods
We prospectively included consecutive pts admitted with CS. A surface 12-lead ECG was performed at admission, recorded at 25 mm/second and 10 mV/cm with commercially available imaging system. P-wave analysis of maximum (P max) and minimum (P min) duration, p-wave dispersion (PWD, defined as the difference between the P max and P min, being abnormal if &gt; 40 msec) and amplitude were evaluated by a two independent operator. P-wave axis was determined by an automated mode available in the equipment. ROC curve was analyzed to determine the optimal cut-off values.

Results
We enrolled 105 pts (55.2% males), with mean age of 68.18 ± 8.83 years, 79% had hypertension, 18.1% had diabetes, 44.8% with dyslipidemia, 21% current smokers.
During follow up period, 18 pts (17.1%) developed AF. We found that only PWD (AUC 0.706, IC95%: 0.564-0.848, p = 0.006) and P-wave axis (AUC 0.715, IC95%: 0.870-0.860, p = 0.004) were strong predictors of AF. PWD cut-off of 47.50 presented a sensitivity of 77.8% and specificity of 59.8% and P-wave axis cut off value of 75.50 had a specificity of 95.4%. Age (p = 0.032) and current smoking (p = 0.014) were associated with occurrence of AF during the follow up.
Conclusion: PWD and P-wave axis predicted incident AF in this subset of pts with cryptogenic stroke. The ECG may be a toll to identify pts at risk of developing AF, although larger studies are needed to confirm these results. Abstract Figure.
Reducing clinical review burden for insertable cardiac monitors
Authors: Gardner RS , Quartieri F , Betts TR , Afzal M , Manyam H , Badie N , Dawoud F , Sabet L , Davis K , Qu F , Ryu K , Ip J 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
The insertable cardiac monitor (ICM) is an essential tool for the ambulatory diagnosis of arrhythmias. However, definitive diagnoses still rely on time-consuming, manual adjudication of electrograms (EGMs) transmitted to the patient care network. This EGM review burden may be minimized by automatically selecting a subset of EGMs for fast review without delaying the diagnosis.

Purpose
Develop EGM selection strategies to reduce the EGM review burden without delaying diagnoses.

Methods
A retrospective analysis of 1,000 randomly selected Abbott Confirm Rx devices with 90+ days of remote transmission history was performed, regardless of transmission frequency, and all EGMs were adjudicated as either true or false positive (TP, FP). Up to 3 EGMs per day per arrhythmia type were prioritized for review based on ventricular rate and episode duration, with rules specific to each arrhythmia type: atrial fibrillation (AF), tachycardia, bradycardia, and pause. The resulting reduction in EGM review burden and TP days (patient-days with at least 1 TP EGM), as well as any diagnostic delay from the first transmitted TP, were calculated relative to reviewing all transmitted EGMs.

Results
In this population and transmission period, at least one AF, tachycardia, bradycardia, and pause EGM was transmitted by 424, 343, 190, and 325 unique devices, respectively, with a total of 35,723, 12,239, 19,752, and 28,002 EGMs, and a total of 6,163, 1,572, 1,438, and 646 TP days. For these patients with ≥1 EGM, the median [IQR] EGM transmission rate was 2.6 [0.7, 11.6], 1.1 [0.4, 4.7], 2.1 [0.6, 10.7], and 3.4 [0.6, 29.9] EGMs/patient/month, respectively. The optimal EGM selection strategy reduced this EGM review burden by 43%, 67%, 76%, and 50%, while only missing 3.4%, 2.2%, 0.3%, and 0.2% of TP days, respectively. Ultimately, 97%, 99%, 99%, and 99% of devices with a TP AF, tachycardia, bradycardia, or pause EGM exhibited no diagnostic delay vs. reviewing all transmitted EGMs.

Conclusion
EGM prioritization rules for selecting up to 3 episodes/day significantly reduced EGM burden across all patients, not just "frequent fliers," with no delay-to-diagnosis in &gt;97% of patients who exhibited a true arrhythmia. Implementing these rules on the patient care network may improve clinical workflow and ICM patient management. Abstract Figure.
The role of ablation index-guided pulmonary vein isolation in high-sensitivity TrThe role of ablation index-guided pulmonary vein isolation in high-sensitivoponin I and atrial fibrillation recurrence
Authors: De Campos D , Puga L , Sousa P , Antonio N , Elvas L 
Published: May 2021

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Ablation Index (AI) software has been associated with better freedom from atrial arrhythmias after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF). There is conflicting data regarding the relationship between high sensitivity cardiac Troponin I (Hs-cTnI) and arrhythmia recurrence. The objective was to evaluate the impact of AI on Hs-cTnI level and on ablation effectiveness quotient (AEQ) and to assess if these markers are predictors of arrhythmia recurrence.

Methods
Prospective observational study of consecutive patients referred for PVI for paroxysmal AF ablation from October 2017 to June 2018 according to a pre-specified AI protocol. Procedural endpoints and 2-year follow-up outcomes were assessed and compared to a retrospective cohort of conventional PVI contact-force-guided group .

Results
A total of 56 patients were included: 29 patients the AI group and 27 patients in the control group. The mean age was 60.5 ± 10.3 years, 48% males. Left ventricular ejection fraction (60 ± 6 % AI vs 61 ± 5 % control, P = 0.07) and left atrium diameter (43 ± 7 mm AI vs 44 ± 6 mm control, P = 0.58) were comparable between groups. First-pass isolation was shown to be higher in the AI group (79% AI vs 44%, p= 0.01). Mean number of radiofrequency applications was lower in the AI group (93 ± 24 vs 111 ± 30, P = 0.02). Average contact-force was similar between groups (17.6 ± 4.1 g vs 22.6 ± 10.7 g, P =0.166). Patients that performed PVI guided by the AI had lower Hs-cTnI (1815 ± 1146 ng/L vs 3274 ± 1696 ng/L, p &lt; 0.001) and lower AEQ (1.01 ± 0.7 ng/L/s vs 1.51 ± 0.7 ng/L/s, P = 0.011) compared to patients in the control group. During a mean follow-up of 26 ± 11 months, AF recurrence was documented in 10.3% of patients in the AI group and 22.2% in the control group (P = 0.223). Neither Hs-cTnI nor AEQ levels were predictors of arrhythmia recurrence.

Conclusions
These data suggest that AI-guided catheter ablation is associated with reduced levels of of Hs-cTnI and AEQ. Neither Hs-cTnI and AEQ should be used to predict arrhythmia recurrence. Abstract Figure.