bluuebunny/crossref_metadata_2025_split huggingface dataset:
Казуистические маски инфаркта миокарда: постинфекционный, сепсис-ассоциированный
Authors: Malsteva L.O. , Nikonov W.W. , Kazimirova N.A. , Lopata A.A. 
Published: April 2021

Целью обзора является представление хронологической последовательности действий при разработке универсальных дефиниций инфаркта миокарда, новых идей для улучшения скрининга постинфекционного и сепсис-ассоциированного инфаркта миокарда — казуистических масок инфаркта миокарда. Очерчены этапы разработки общего и всемирного определения инфаркта миокарда: 1 — рабочими группами ВОЗ на основе электрокардиографии для эпидемиологических исследований; 2 — совместно Европейским обществом кардиологов и Американским колледжем кардиологов с использованием клинического и биохимического подходов; 3 — создание Глобальной целевой группой консенсусного документа универсального определения с последующей классификацией инфаркта миокарда на пять подтипов (спонтанный; диссонанс в доставке и потреблении кислорода; летальный исход до подъема специфических маркеров повреждения миокарда; ассоциированный с чрескожным коронарным вмешательством; ассоциированный с аортокоронарным шунтированием); 4 — пересмотр объединенной целевой группой указанного выше документа на основе включения в него более чувствительных маркеров — тропонинов; 5 — выделение 17 неишемических повреждений миокарда, сопровождающихся повышением уровня тропонина; 6 — характеристика предсердного натрийуретического пептида с позиций его синтеза, хранения, высвобождения, диагностической значимости как биомаркера острого повреждения миокарда; 7 — клиническое определение инфаркта миокарда, представленное в материалах III Консенсуса по инфаркту миокарда 2017 года. Постановка диагноза инфаркта миокарда с использованием критериев, изложенных в этом документе, требует интеграции клинических данных, паттернов электрокардиографии, лабораторных данных, наблюдений визуализации и в отдельных случаях — патологических результатов, которые рассматриваются в контексте временного горизонта, под которым подозреваемое событие разворачивается. K. Thygesen et al. рассматривают дополнительное использование: сердечно-сосудистого магнитного резонанса для определения этиологии повреждения миокарда; компьютерной коронарной ангиографии при подозрении на инфаркт миокарда. Инфаркт миокарда — это сочетание специфических кардиомаркеров с хотя бы одним из признаков, приведенных выше. Формирование инфаркта миокарда происходит и при/после острой инфекции дыхательных путей. Установлены причинно-следственные связи между этими двумя состояниями. Постинфекционный инфаркт миокарда настоятельно рекомендуется индивидуализировать как отдельную нозологическую единицу. При сепсисе глобальная миокардиальная ишемия и в итоге ишемическое повреждение миокарда возникают в результате гуморальных и клеточных факторов, сопровождаются повышением уровня тропонинов, снижением фракции выброса левого желудочка на 45 % и увеличением конечных диастолических размеров левого желудочка, развитием сепсис-ассоциированного синдрома полиорганной недостаточности, что является неблагоприятным фактором прогноза.
Клинический опыт лечения легочных осложнений висцеральной формы ветряной оспы
Authors: Shuman E.P. , Venher I.V. , Podoliak A.A. , Pylypenko A.V. , Kosukha D.A. 
Published: April 2021

Ветряная оспа вызывается высококонтагиозной вирусной инфекцией с воздушно-капельным механизмом передачи, которая чаще встречается у детей и, как правило, имеет благоприятный исход. Однако в ряде случаев это заболевание может приводить к серьезным, потенциально летальным осложнениям, которые чаще встречаются у взрослых. Одним из самых грозных осложнений является пневмония. В статье приводится описание клинического случая пациента, у которого ветряная оспа осложнилась двусторонней тотальной пневмонией.
Распространенность различных форм несахарного диабета и его осложнений в Республике Узбекистан
Authors: Urmanova Yu.M. , Khamraeva D.I. 
Published: April 2021

Актуальность. Центральный несахарный диабет (НД) — заболевание, характеризующееся неспособностью почек реабсорбировать воду и концентрировать мочу, имеющее в своей основе дефект синтеза или секреции вазопрессина и проявляющееся выраженной жаждой и экскрецией большого количества разведенной мочи. Цель исследования — оценка распространенности различных форм несахарного диабета и его осложнений, качества диагностики и лечения по данным областных эндокринологических диспансеров Республики Узбекистан (РУз). Материалы и методы. В исследовании использованы данные регистра больных НД, состоящих на учете в областных эндокринологических диспансерах всех регионов Республики Узбекистан и Республики Каракалпакстан (РКК) в 2018 году, а также собственные наблюдения. Установлено, что в РУз и РКК на конец 2018 г. на учете состояли 1237 детей и подростков, больных НД. Проведен анализ 397 случаев заболевания НД. Средний возраст больных составил 5,6 ± 2,0 года. Результаты. Преимущественно наблюдалась идиопатическая форма НД — 214 больных (55,8 %), на втором месте по встречаемости находилась центральная форма НД — 129 больных (40,9 %), в то время как реже наблюдалась почечная форма — 26 (3,3 %) и наследственная форма заболевания — 3 (0,2 %). Большинство больных (48,9 %) не связывали начало заболевания с каким-либо фактором. Однако у 20,4 % больных несахарный диабет развился после травмы черепа. У 4,8 % больных причиной болезни явились опухоли гипоталамо-гипофизарной области, а у 14,5 % больных — нейровирусная инфекция. Наследственная предрасположенность была у 0,4 % больных. Выводы. В регионах Республики Узбекистан и РКК наиболее часто наблюдались две формы несахарного диабета: идиопатическая — 214 (55,8 %) и центральная — 129 случаев (40,9 %). Наибольшее число больных было в возрасте от 0 до 9 лет — 85 пациентов (22,9 %). Средний возраст больных детей и подростков составил 7,6 года. Заболевание чаще встречалось у лиц мужского пола (51,1 %).
The application of rock phosphate increases the growth and yield of rice on acid sulphate soil of South Kalimantan, Indonesia
Authors: Ahmad Suriyanti , Utami Sri Nuryani Hidayah , Ma'as Azwar , Yusuf Wahida Annisa , Husnain Husnain 
Published: April 2021

A swampland has considerable potential in agriculture. This land has high soil acidity level, and high iron content. Therefore, the application of ameliorant to acid sulfate soil is essential to improve the soil and make it more suitable for rice cultivation. This study aimed to know the effects of phosphorus (P) from Moroccan Rock Phosphate (MRP) and fertilization on swamp rice (Oryza sativa L.). The experiment was conducted at the experimental location of Indonesian Swampland Agricultural Research Institute (ISARI), Puntik Village, Barito Kuala District, South Kalimantan and arranged in a randomized nested design consisting of 100 kg.ha-1 TSP (Control), 750 kg.ha-1, 1,000 kg.ha-1, and 1,250 kg.ha-1 Moroccan rock phosphate with four replications in each treatment. The yield component of grain increased significantly at 3.77 ton.ha-1. The highest of grain yield was obtained in the application of 1,000 kg.ha-1 MRP. Meanwhile, significant positive correlation was observed between plant height and the number of spikelets per panicle. The application of phosphate fertilizer can increase soil pH, which affects the growth and yield of rice plants such as plant height and yield.
EVALUATION AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE USE OF BERBERINE FROM COPTIS TEETA BARK AS ANTI-CANCER PHYTOCHEMICAL
Authors: CHONDHE MADHURI , HANDE SWAPNALI , SINGH SONIA 
Published: April 2021

Objective: A new method of analysis using high-performance liquid reverse chromatography (HPLC) to calculate berberine in Coptis teeta bark was created in addition to the validation research.
Methods: Berberine was analyzed with potassium hydrogen phosphate and acetonitrile using the SunFire C18 column at a flow rate of 1.0 ml/min; 5μ (4.6 × 250 mm) was detected at 347 nm.
Results: For precision, selectivity, and linearity, the technique was tested. The quantification of berberine did not conflict with the existence of other chemical components. Between concentrations of 60 and 180 ppm, the calibration curve was linear. The precision ranged from 9.0% to 102.0% and 2% was the relative standard deviation.
Conclusion: Finally, this method of HPLC enhancement is simple, effective and has been used to classify and quantify berberine successfully. This can be useful for the study of different berberine-containing plant extracts and can also be used to measure berberine from formulation to herbal formulation.
EVALUATION OF THE ACUTE AND SUBCHRONIC TOXICITY STUDIES OF BARLERIA BUXIFOLIA LINN. IN ALBINO RATS
Authors: REDDY MANOHAR , SUNDARARAJAN RAJA 
Published: April 2021

Objective: The fundamental reason for this examination was to look at the acute and subchronic toxicity studies of chloroform and methanol extracts of Barleria buxifolia Linn. (Acanthaceae) on creature models according to the OECD rules 407 and 425, respectively.
Methods: In acute oral toxicity, study a single oral dosages of 5000 mg/kg body weight of chloroform and methanol extracts was given individually to rats and watched them for 2 weeks for the discovery of acute changes and for its mortality any. During acute oral toxicity study period, no mortality was seen without any signs of intense changes. Further, it was executed the subchronic toxicity of extracts. Barleria buxifolia extracts (chloroform and methanol) were independently given every day at dosages of 250 and 500 mg/kg body weight for 90 days to recognize the progressions any at subchronic poisonousness levels. Towards the finish of the experimentation the serum tests of trail creatures were gathered and watched for any progressions in haematological, biochemical and histopathological boundaries
Results: All parameters of treated group were shown unaltered changes throughout the study period when compared with that of normal group. The outcomes propose that the oral organization of chloroform and methanol extracts of Barleria buxifolia did not raise any huge poisonous impacts when contrasted with that of control animals.
Conclusion: Hence, the extracts may be safe for therapeutic use and as an alternative system of medicine.
IDENTIFICATION AND DETECTION OF BIOFILM PRODUCING STAPHYLOCOCCUS AUREUS AND ITS ANTIBIOGRAM ACTIVITIES
Authors: SHARMA SAPANA , BHANDARI UPASHANA , OLI YOGESH , BHANDARI GANESH , BISTA SUNITA , GC GANGA , SHRESTHA BASUDHA , BHANDARI NETRA LAL 
Published: April 2021

Objectives: The main aim of this work is to determine the antibiogram profile of biofilm-producing Staphylococcus aureus from various clinical specimens of the patients.
Methods: Various bacterial cultures of non-repeated clinical specimens from a total of 3388 patients were determined using standard microbiological and biochemical methods.
Results: Out of 3388 only 604 (17.02%) displayed growth positive. A total of 65 (51.58%) S. aureus isolates were recovered, 25 (38.46%) were identified as methicillin-resistant S. aureus (MRSA) by Cefoxitin (30 μg) disk diffusion technique, of which majority were from pus/wound swab 22 (37.29%). The antibiogram of the isolates was analyzed by Kirby-Bauer disk diffusion technique analyzing Linezolid to be the most effective drug with susceptibility of 100% to both MRSA and methicillin-sensitive S. aureus, followed by vancomycin, tigecycline, and tetracycline. In vitro biofilm production by tissue culture plate (TCP) and Congo red agar method detected 52 (80%) and 25 (38.46%) as biofilm producers, respectively. TCP identified 2 (3.07%), 7 (10.76%), and 44 (67.69%) as strongly, moderately, and weakly adherent. About 30.7% of MRSA obtained were positive biofilm producers. The minimum inhibitory concentration value of Oxacillin for S. aureus by agar dilution method ranged from 0.025 μg/mL to 128 μg/mL.
Conclusion: This study shows that biofilm production was more in methicillin-resistant strains and displayed a high degree of resistance to almost all groups of antibiotics.
PRELIMINARY SCREENING OF PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, AND ANTI-BACTERIAL ACTIVITIES IN THE METHANOLIC LEAF EXTRACT OF MELIOSMA SIMPLICIFOLIA (L.)
Authors: S PAVITHRA , T SEKAR 
Published: April 2021

Objective: In the present study is investigated of phytochemicals and antioxidant activities of the leaf extracts from Meliosma simplicifolia (L.).
Methods: The seaweed sample was subjected to extraction with solvents of different polarities (hot water, methanol, acetone, chloroform, and petroleum ether) and screened for phytochemicals according to standard methods. The ability of the plant extract to act as hydrogen/electrons donor or scavenger of radicals was determined by in vitro antioxidant assays using 2,2-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging, reducing power assay, and superoxide radical (O2•) scavenging activity. The ICPMS and GC-MS analysis of the methanol leaf extract of M. simplicifolia was revealed the presence of antibacterial.
Results: Phytochemical analysis revealed the presence of Preliminary metabolites Quantitative studies of estimated phenol, flavonoid and tannin, as for the methanol extract of stem showed the highest content of phenolic compounds (40.71±0.94 GAE mg/100). Antioxidant activities were concluded the estimation M. simplicifolia leaf for as followed the studies. In leaf the highest DPPH scavenging activity (132.3 μg/ml), ICP-MS analysis of the leaf extract showed the presence minerals such as Mg, Fe, Cu, Na, and Zn in excess. The leaf extract of the plant was also tested for its antibacterial activity and results confirmed that it has potential activity.
Conclusion: The preliminary studies in the methanol extract of the leaf of M. simplicifolia are suggestive of the antibacterial potentials of the methanol extract of leaves of M. simplicifolia.
ROLE OF SUNKIST PEELS EXTRACT AGAINST THE LEVEL OF ESTRADIOL AND MATURITY OF FOLLICLE IN THE FEMALE WISTAR RAT
Authors: MUTIA MAYA SARI , SUHARTINA  
Published: April 2021

Objective: The purpose of this study is to investigate the effect of Sunkist peel extract against the estradiol level and ovarian follicle in the female Wistar rats.
Methods: This study was used 25 rats that were divided into five groups, namely, control (Na-CMC), standard (ethinylestradiol), and Sunkist peels extract-I, II, and III (300 mg/kg BW, 450 mg/kg BW, and 600 mg/kg BW). After 14 days, all rats were sacrificed by chloroform inhalation, and the ovarium was excised to histopathology preparation; meanwhile, the blood was collected for the serum. The histology and serum were determined the percentage of each type of follicle and the estradiol level, respectively.
Results: The result of this study showed that increasing of the extract significantly increased not the level of estradiol level (p<0.05) but also the percentage of secondary and de Graaf follicle (p<0.05). Nevertheless, the percentage of primordial and primer follicle decreased, followed by increasing the extract dosage (p<0.05).
Conclusion: It can be concluded that the Sunkist peels Sunkist peel increase both the level of estradiol serum and maturity of the follicle that increases the opportunity of female rats to be fertilized.
A STUDY OF DRUG UTILIZATION IN PATIENTS OF CARCINOMA BREAST RECEIVING SYSTEMIC CHEMOTHERAPY IN TERTIARY CARE HOSPITALS
Authors: SHAH SUCHI , SINGH ANIL , MUNDHAVA SHAILESH 
Published: April 2021

Objective: The objective of the study is to study drug utilization in patients with breast carcinoma receiving systemic chemotherapy in government as well as private set-up.
Methods: This was a record-based, retrospective-prospective study, analyzing the prescription pattern of drugs used for systemic chemotherapy in patients diagnosed with carcinoma breast at government teaching hospital (GTH) and private trust hospital (PTH) for 1 year in 600 patients. Patient’s demographic, clinical, and therapeutic data were collected from the files and personal interviews and analyzed in Microsoft Excel.
Results: Diagnosis of breast carcinoma was highest in age bracket of 40–49 years (32.33% GTH and 32.67% PTH), and the most common presenting symptom was painless lump (76.33% GTH and 83% PTH). In GTH, most frequently prescribed regimen was 4AC → 4T → RT (17.33%). In PTH, most commonly prescribed regimen was 6FEC → RT (19.33%). Highest prescribed drugs were A (32.8%), C (29.12%), and F (20.24%) in GTH and A (32.26%), F (31.68%), and E (16.45%) in PTH. Average number of drugs prescribed per prescription was 12.55 and 11.37; percentage of chemotherapeutic agents prescribed by generic name was 100 and 95.02, and from the WHO essential drug list (2015) was 96.43 and 82.77 in GTH and PTH, respectively (A= Cyclophosphamide, C= Doxorubicin, T=Taxanes [Paclitaxel/Docetaxel], F=5-fluorouracil, E=Epirubicin, RT=Radiotherapy, → followed by, the number indicates chemotherapy cycle).
Conclusion: The study results can help in generating local data regarding drug use pattern of the systemic chemotherapeutic agents in breast cancer patients and promote rational drug use.
Eksistensi Tradisi Mangupa Batak Mandailing di Kelurahan Yukum Jaya Lampung Tengah
Authors: Imron Ali , Perdana Yusuf , Siregar Rizky Rahfan Abadi 
Published: April 2021

Tradisi mangupa merupakan sebuah tradisi yang sampai sekarang masih dilakukan oleh masyarakat Batak Mandailing. Penelitian ini bertujuan untuk mengetahui bagaimana persepsi masyarakat terhadap tradisi mangupa, bagaimana implementasi tradisi mangupa di Kelurahan Yukum Jaya, dan bagaimana eksistensi tradisi mangupa di tengah arus modernisasi. Metode dalam penelitian ini adalah metode kualitatif dengan pendekatan deskriptif. Tahapan penelitian ini adalah pengumpulan data, reduksi data, penyajian data, dan kesimpulan. Hasil penelitian dijabarkan sebagai berikut: (1) persepsi masyarakat terhadap tradisi mangupa adalah ungkapan rasa syukur kepada Tuhan Yang Maha Esa atas kelancaran dalam suatu acara, (2) implementasi tradisi mangupa di Kabupaten Lampung Tengah terdapat beberapa tahapan, mulai dari mengadakan musyawarah, pemberian nasihat dari Dalihan Na Tolu kepada kedua mempelai, hingga memberikan isi pangupa sebagai pedoman hidup setelah menikah, dan (3) tradisi mangupa di Lampung Tengah, khususnya Kelurahan Yukum Jaya masih eksis, dibuktikan dengan setiap acara perkawinan Batak Mandailing dipastikan melaksanakan tradisi mangupa. Tradisi mangupa memuat nilai toleransi dan gotong-royong yang dibuktikan dengan partisipasi masyarakat umum saat tradisi ini dilakukan.

The mangupa is a tradition that is still practiced by the Mandailing Batak community. This study aims to determine how do people perceive the mangupa tradition, how the implementation of the mangupa tradition in Yukum Jaya Village, and how is the existence of the mangupa Tradition amid modernization. The method in this research is a qualitative with a descriptive approach. The stages of this research are as data collection, data reduction, data presentation, and conclusions. The results of the research are described as follows: (1) public perception of the mangupa tradition is an expression of gratitude to God Almighty for the smooth running of an event. (2) the implementation of the mangupa Tradition in Central Lampung Regency consists of several stages, starting from holding deliberations, giving advice from Dalihan Na Tolu to the bride and groom to providing Pangupa contents as a guide for life after marriage, and the mangupa tradition in Central Lampung, especially Yukum Jaya Village, still exists, as evidenced by the fact that every Batak Mandailing wedding ceremony is ensured to carry out the mangupa tradition. The mangupa tradition contains the values ​​of tolerance and cooperation, which is evidenced by the participation of the general public when this tradition is carried out.
The Concept of Spiritual Tourism
Authors: Rifa'i Novi , Kamaludin Mohammad 
Published: April 2021

Komunikasi transendental dapat terlihat oleh banyak orang di objek-objek wisata yang ada di lingkungan sekitar kita, seperti upacara kehamilan, kelahiran, sunat, pertunangan, pernikahan, ucapan syukur dan kematian. Melalui penelitian ini para peneliti ingin mengeksplorasi nilai-nilai spiritual yang menjadi obyek pariwisata. Penelitian kualitatif ini akan mengungkap fokus kajian nilai spiritualitas pariwisata dalam mengembangkan konsep wisata spiritual berdasarkan kegiatan pariwisata yang telah dilakukan dengan berbagai atraksi. Jenis penelitian ini merupakan penelitian kualitatif dengan menggunakan pendekatan deskriptif-filosofis. Penelitian ini menggunakan pendekatan deskriptif karena bertujuan untuk mengungkap konsep wisata spiritual yang tepat untuk wisata ramah muslim. Nilai spiritual pariwisata dalam Islam adalah pendekatan yang dilakukan oleh manusia kepada Allah SWT dalam menjalankan kegiatan pariwisata. Upaya yang dilakukan adalah menjauhkan haram dan melaksanakan yang halal, baik dalam aktivitas makanan maupun pariwisata. Konsep wisata spiritual yang dihadirkan adalah dengan selalu menggabungkan 4 (empat) elemen dalam menjalankan aktivitas, keempat elemen ini adalah pelaku pariwisata, keberadaan Allah atau kekuatan SWT dalam setiap aktivitasnya, kebijaksanaan Sumber Daya Manusia penyedia layanan, dan keharmonisan, kondisi alam lingkungan yang mengarahkan kepada getaran jiwa atas kehadiran Sang Pencipta di setiap langkah.

Transcendental communication is seen by many people in tourism objects in our surroundings, such as ceremonies of pregnancy, birth, circumcision, engagement, marriage, thanksgiving and death. Through this research, researchers want to explore spiritual values ​​in tourism. This qualitative research will reveal the focus of the study of the tourism spirituality value and develop the concept of spiritual tourism based on tourism activities that have been carried out with various attractions. Thus, the type of research is qualitative research, using descriptive-philosophical approaches. This study uses a descriptive approach because it aims to disclose the spiritual values of tourism. In the other hand this study also analyzes the right concept of spiritual tourism for Moslem friendly tourism. The spiritual value of tourism in Islam is an approach taken by humans to Allah SWT in carrying out tourism activities. The efforts taken are to avoid the haram and the conduction of the corrupt ones, both in food and tourism activities. The concept of spiritual tourism that is presented always combines 4 (four) elements in conducting activities, these four elements are tourism actors, the existence or power of Allah SWT in each of its activities, the wisdom of service providers, harmony and the atmosphere of natural environments thrilling the tourist actors to the The Creator in each of their steps.