bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate Intravenous Epinephrine Versus Early Intravenous Epinephrine for In-Hospital Cardiopulmonary Arrest
Authors: Bakhsh Abdullah , Safhi Maha , Alghamdi Ashwaq , Alharazi Amjad , Alshabibi Bedoor , Alobaidi Rajwa , Alnashri Maryam 
Published: February 2021

Abstract
Background

intravenous epinephrine has been a key treatment for cardiopulmonary arrest since the early 1960s. Although, many studies have questioned neurological outcome benefit, it remains to be recommended in international guidelines for its benefit on return of spontaneous circulation (ROSC). The ideal timing for the first epinephrine dose is uncertain. We aimed to look at the association of immediate epinephrine administration (within 1-minute of cardiac arrest recognition) with return of spontaneous circulation (ROSC) up to 24-hours and beyond 24-hours.
Methods

this was a multicenter retrospective chart review of patients undergoing cardiopulmonary resuscitation. Descriptive statistics were used to characterize study population, while t-test and chi-square were used to compare groups and outcomes.
Results

immediate epinephrine administration (within 1-minute) is associated with higher rates of ROSC up to 24-hours (OR = 2.36, 95% CI; [1.46–3.81]) and beyond 24-hours (OR = 2.26, 95% CI; [1.06–4.83]).
Conclusions

we encourage immediate administration of epinephrine in conjunction with high-quality CPR, as this is associated with higher rates of ROSC.
Clinical Features and High-risk Factors Prediction of Multiple Fiberoptic Bronchoscopy Therapy of Plastic Bronchitis in 269 Children
Authors: Zhang Tongqiang , Zhao Lihua , Zheng Jiafeng , Zhao Linsheng , Cui Xiaojian , Xu Yongsheng , Cai Chunquan 
Published: February 2021

Abstract
Background. To analyze the clinical features of children with plastic bronchitis (PB) and identify the risk factors of multiple flexible fiberoptic bronchoscopy (FOB) therapy.Methods. Retrospective analysis was performed on 269 PB children from 2016 to 2019, 144 cases were in single FOB group, 125 cases were in the multiple FOB group. The clinical manifestations, laboratory datas, imaging findings and management were investigated. The different features were compared between the single FOB group and multiple FOB group.Results. A total of 269 PB children were collected with a mean age of 6.7 ± 2.8 years. 257 (95.5%) cases were diagnosed as Mycoplasma pneumonia (MP) infection. The mean duration of fever was 10.6 ± 3.7 days. All the patients presented with fever, and 62 (23.0%) suffered from hypoxemia, 144 (53.5%) had extrapulmonary complications. Higher levels of ESR, CRP, PCT, IL-6, LA, LDH, FER and D-dimer were observed. The proportion of pulmonary consolidation, segmental or lobar atelectasis, pleural effusion and pleural thickening were 97.4%, 46.5%, 47.9% and 63.2%, respectively. Furthermore, multivariate logistic regression analysis showed that N% >75.5%, LDH >598.5U/L, and D-dimmer>0.45mg/L were independent isk factors for multiple FOB therapy. Conclusions. MP is a significant pathogen of PB in children. Patients with PB are more likely to suffer from persistent fever, excessive inflammation and severe radiological findings. N% >75.5%, LDH >598.5U/L and D-dimmer > 0.45mg/L may be predictors of multiple FOB treatment.
Radiofrequency Ablation for Renal Tumours: A Retrospective Cohort From a Tertiary Hospital in Australia
Authors: Al-Zubaidi Mohammed , Lotter Kennia , Marshall Martin , Lozinskiy Mikhail 
Published: February 2021

Abstract
Purpose: This cohort aimed to evaluate the safety and efficacy outcomes of percutaneous radiofrequency ablation (RFA) for localised renal cell carcinoma (RCC) in a Western Australia tertiary hospital, Royal Perth Hospital (RPH), and potential associations between age, gender, tumour size, location, chronic kidney disease, comorbidities and local recurrence against existing benchmarks. Methods: We retrospectively analysed survival outcomes for patients with biopsy proven RCC treated by RFA at Royal Perth Hospital between 2009 and 2018. Complication data were gathered for all patients that underwent renal RFA along with 2- and 5-year recurrence-free (RFS) and compared the outcomes with data from previous studies. I confirm that all methods were carried out in accordance with relevant guidelines and regulations. Results: A total of 69 patients (73 procedures) were eligible for the study with biopsy-proven RCC had minimum 2-year follow-up. The RPH complication rate was 8.2 % (6/73) and local recurrence rate 10.9 % (8/73). Two-year RFS is 95.6% and Five-year RFS is 78.78% on a median 3.82-year follow-up (IQR 1.9-5.75). Conclusion: Radiofrequency ablation performed at our centre was found to be safe and effective with low complication rates and durable RFS in line with expectations from existing research. Our study demonstrated that radiofrequency ablation is an alternative modality of treatment for small renal tumours in patients unfit for surgical approach.
Insights Into Physical Activity Adoption in Diabetes Patients: When Cultural Materialism Met the Transtheoretical Model
Authors: Jabardo-Camprubí Guillem , Bort-Roig Judit , Donat-Roca Rafel , Martín-Horcajo Montserrat , Puig-Ribera Anna , McKenna Jim 
Published: February 2021

Abstract
Background

Although physical activity (PA) is a key behaviour for preventing and controlling diabetes (T2DM), low adoption-adherence continues to impair patient progress. Importantly, for many patients, intentional PA may have never been central to their wider cultural context. Therefore, progress in behaviour change may be more about collective than individual processes. The aim of this study was to identify barriers to undertake and maintain PA overtime and describe the relationship and the influence between these barriers in T2D patients’ real-life.
Methods

Twenty-two T2D patients contributed either to focus groups (n = 5) or to semi-structured interviews (n = 4). We explored adoption-adherence using an established behaviour change model (Transtheoretical) and an anthropological research method (Cultural Materialism) throughout a qualitative analysis.
Results

Findings suggested patients responded to PA promoted through medicalised services, using two basic, yet inter-related, social processes. To consider adopting PA a Basic Social Psychological Process was used. In contrast, patients willing to sustain PA focused on prominent ‘infrastructural’ barriers, using a Basic Social Structural Process.
Conclusion

This interpretation simplifies in two processes the change of behaviour related to PA. At the same time, defines the barriers’ relationship between the different levels and the influence that each level has in patients’ real-life. These insights support using phased, ecological frameworks to design and promote PA to patients with T2D, so they maintain changes over time.
Emotional Distress in the Early Stages of the Corona Related Lockdowns Depending on the Severity of the Pandemic and Emergency Measures: A Comparative Online-survey in Germany, Austria and Italy
Authors: Eichenberg Christiane , Grossfurthner Martin , Kietaibl Sybille , Riboli Greta , Borlimi Rosita , Holocher-Benetka Stefana 
Published: February 2021

Abstract
Background: The first wave of the COVID-19-pandemic hit different countries with varying degrees of severity, so that differences in the type and level of emergency measures were also necessary. It can be assumed that the psychological burden was higher in countries with a more severe process of the pandemic (Italy) than in countries with a less severe (Germany, Austria). Objective: To investigate und contrast the wellbeing of the population in Italy, Austria and Germany in the early phase of the first lockdown. Method: Online survey on N= 4289 individuals. The questionnaire comprised 1. self-administered section, exploring the dimensions perceived severity of COVID-19, perceived risk of disease, concerns related to COVID-19, emergency measures acceptance and emotional distress due to emergency measures 2. standardized scales to record personality determinants: Stress-CopingStyle-Questionnaire, Positive and Negative Affect Schedule, State-Trait-Anxiety-Inventory. Results: The three countries displayed significant differences in all personality dimensions. Italian participants assessed the COVID-19 virus as much more dangerous, but despite the prevalence of the virus, the subjective risk of disease is perceived to be lower in Italy. This could be a positive effect of the restrictive curfews set by the government in Italy. The emergency measures were generally perceived to be very effective in all three countries, but due to duration and the severity of the measures the fear and stress-reaction was the strongest within the Italians. Conclusion: The stricter measures in Italy prevented an application of many positive stress processing strategies, which, in turn, fostered the preservation of stresses and fear.
Genome-Wide Identification of MYB Gene Family Reveals Their Potential Functions in Cadmium Stress Response and the Regulation of Cannabinoid Biosynthesis in Hemp (Cannabis sativa L.)
Authors: yin ming , pan gen , tao jie , zhao lining , li zheng , jiang hui , tang huijuan , chang li , li jianjun , chen anguo , deng yong , zhang cuiping , li defang , huang siqi 
Published: February 2021

Abstract
Backgroud: Heavy metal pollutant, Cadmium (Cd), is an inorganic pollutant in China. Hemp (Cannabis sativa L.) is an important fiber crop to remediate heavy metal-contaminated soils. The MYB family is one of the largest and most important gene families that influences plant growth and produce secondary metabolites. Results: 115 CsMYB genes were identified in the hemp genome. The 1R-MYB subfamily had 17 genes, the 2R-MYB subfamily 88 genes, and the 3R-MYB subfamily 8 genes. The synteny analysis of the CsMYB genes indicated that there were 3 pairs of tandem repeats, 21 pairs of segmental duplication, 6 CsMYB genes present before species differentiation, and 60 genes belonging to the hemp-specific CsMYB genes. 7 CsMYB genes were identified to influence the response to Cd stress by combining the transcriptome data of two hemp species under Cd stress. Based on the changes in the Cannabinoid content of hemp under Cd stress, the expression of different CsMYB genes in hemp with high and low cannabidiol (CBD) contents, and tissue-specific expression, it was inferred that CsMYB024 may be affected by Cd stress and mediate the CBD synthesis pathway.Conclusions: This study provides a comprehensive analysis of the hemp MYB family. These results should be helpful in understanding of their potential functions in Cd-Stress Response and the Regulation of Cannabinoid Biosynthesis in Hemp. In addition, lays the foundation for the further study of biological functions of CsMYBs in hemp.
Comprehensive Analysis of Prognostic Value and Immune Infiltration of Kindlin Family Members in Non-Small Cell Lung Cancer
Authors: Su Xiaoshan , Liu Ning , Wu Weijing , ZHU ZHIXING , Xu Yuan , He Feng , Chen Xinfu , Zeng Yiming 
Published: February 2021

Abstract
Background: Kindlin Family Members have been reported to be aberrantly expressed in various human cancer types and involved in tumorigenesis, tumor progression, and chemoresistance. However, their roles in non-small cell lung cancer (NSCLC) remain poorly elucidated. Methods: We analyzed the prognostic value and immune infiltration of Kindlins in NSCLC through Oncomine, GEPIA, UALCAN, CCLE, Kaplan‑Meier plotter, cBioPortal, TIMER, GeneMANIA, STRING, and DAVID database. Additionally, the mRNA expression levels of Kindlins were verified in 30 paired NSCLC tissues and NSCLC cell lines by real-time PCR. Results: The expression level of FERMT1 was remarkably increased in NSCLC tissues and NSCLC cell lines, while FERMT2 and FERMT3 were reduced. Kindlins expressions were associated with individual cancer stages and nodal metastasis status. We also found that higher expression level of FERMT1 was obviously correlated with worse overall survival (OS) in patients with NSCLC, while higher FERMT2 was strongly associated with better overall survival (OS) and first progression (FP). Additionally, the expression of FERMT2 and FERMT3 were obviously correlated with the immune infiltration of diverse immune cells. Functional enrichment analysis has shown that Kindlins may be significantly correlated with intracellular signal transduction, ATP binding and the PI3K-Akt signaling pathway in NSCLC. Conclusions: The research provides a new perspective on the distinct roles of Kindlins in NSCLC and likely has important implications for future novel biomarkers and therapeutic targets in NSCLC.
Calculating Method of Dielectric Permittivity of 8YSZ in Different Relative Humidity with Low Water Contents
Authors: Kong Myong Nam , Yu Nam-Chol , Kim Jin Sim , Kim Kwang Jun 
Published: February 2021

Abstract
An improved approach for calculating the dielectric permittivity of 8 mol% yttria-stabilized zirconia (8YSZ) in different relative humidity corresponding to low water contents is proposed. For this, a new virtual pore constituted by air and water is proposed using the microstructural modeling. 8YSZ material is assumed to be made up of 8YSZ solid and virtual pore. The results showed that the dielectric permittivity of the virtual pore is calculated using the upper limit of the Wiener approach for low water contents, and the effective dielectric permittivity of 8YSZ material constituted by solid and virtual pore in different relative humidity using Jayannavar’s expression. The proposed approach gives a better interpretation of the experimental results in different relative humidity corresponding to low water contents.
A-DenseUNet: Adaptive Densely Connected UNet for Polyp Segmentation in Colonoscopy Images with Atrous Convolution
Authors: Safarov Sirojbek , Whangbo Taeg Keun 
Published: February 2021

Abstract
Colon carcinoma is one of the leading causes of cancer-related death in both men and women. Automatic colorectal polyp segmentation and detection in colonoscopy videos help endoscopists to identify colorectal disease more easily, making it a promising method to prevent colon cancer. In this study, we developed a fully automated pixel-wise polyp segmentation model named A-DenseUNet. The proposed architecture adapts different datasets, adjusting for the unknown depth of the network by sharing multiscale encoding information to the different levels of the decoder side. We also used multiple dilated convolutions with various atrous rates to observe a large field of view without increasing the computational cost and prevent loss of spatial information, which would cause dimensionality reduction. We utilized an attention mechanism to remove noise and inappropriate information, leading to the comprehensive re-establishment of contextual features. Our experiments demonstrated that the proposed architecture achieved significant segmentation results on public datasets. A-DenseUNet achieved a 90% Dice coefficient score on the Kvasir-SEG dataset and a 91% Dice coefficient score on the CVC-612 dataset, both of which were higher than the scores of other deep learning models such as UNet++, ResUNet, and U-Net, for segmenting polyps in colonoscopy images.
Nimesulide Poisoning in White-Rumped Vulture Gyps Bengalensis in Gujarat, India
Authors: Nambirajan Kanthan , Muralidharan Subramanian , Ashimkumar Aditya Roy , Jadhav Shashikant 
Published: February 2021

Abstract
Catastrophic population decline of White-rumped Vulture due to use of a non-steroidal anti-inflammatory drug (NSAID), diclofenac throughout its distribution range is well documented. White-rumped Vulture was listed as Critically Endangered and only few thousands are remining. During 2019, there were two incidents of White-rumped Vulture death in Gujarat. In February 2019, two vultures were reported dead in Sanand, Gujarat and the death was suspected to be poisoning. Another two vultures were also reported to have died in Wild Ass Sanctuary, Dhrangadhra in October 2019. Tissues and gut contents of all four vultures were received for toxicological investigation and checked whether these vultures died due to NSAIDs. The tissues were analysed for thirteen NSAIDs. Of all the NSAIDs, nimesulide was detected in all the tissues analyzed in high concentration (17 - 1395 ng/g). Subsequently, these tissues were also screened for a set of mostly used toxic pesticides in India, and none of them was in toxic level. Visceral gout was also observed in all the four vultures during post-mortem. Elevated levels of nimesulide in tissues with clear symptoms of gout, indicated that the vultures died due to nimesulide poisoning. Although, other than diclofenac, many NSAIDs are toxic/suspected to be toxic to White-rumped Vultures, only nimesulide is reported with clear symptom of gout in wild dead White-rumped Vultures similar to diclofenac consistently in recent past. Considering the fact that nimesulide also acts similar to diclofenac leading to death in White-rumped Vulture, it seems that nimesulide is replacing diclofenac in case of White-rumped Vulture in Gujarat. Nimesulide is cause of concern in conservation of White-rumped Vultures. Hence, nimesulide should also be banned by the government for veterinary use in addition to diclofenac to conserve White-rumped Vulture in Indian subcontinent. Further, an effective system is recommended to be put in place to collect the tissues of dead Vultures for toxicological investigations, and eventual conservation of the critically endangered species.
Using Intervention Mapping to Develop and Facilitate Implementation of a Multifaceted Behavioural Intervention Targeting Physical Activity and Sedentary Behaviour in Stroke Survivors: Physical Activity Routines After Stroke (PARAS)
Authors: Moore Sarah , Flynn Darren , Price Christopher , Avery Leah 
Published: February 2021

Abstract
BackgroundThe benefits of increased physical activity for stroke survivors include improved walking ability, balance and mood. However, less than 30% achieve recommended levels of physical activity, and high levels of sedentary behaviour are reported. We engaged stroke survivors, informal carers and healthcare professionals (HCPs) in a co-design process to develop an evidence-informed behavioural intervention targeting physical activity and sedentary behaviour for use by stroke rehabilitation teams. MethodsIntervention Mapping was used as a framework for intervention development. Step 1 involved a systematic review, focus group discussions and a review of existing care pathways. Step 2 involved identification of social cognitive determinants of behavioural change and behavioural outcomes of the intervention. Step 3 involved linking the determinants of behavioural outcomes with specific behaviour change techniques to target the behaviours of interest. Step 4 involved the development of the intervention informed by steps 1 to 3. Subsequently, an implementation plan was developed (Step 5) followed by an evaluation plan (Step 6). ResultsSystematic review findings informed selection of nine ‘promising’ behaviour change techniques (e.g. goal setting-behaviour; problem-solving). Focus groups with stroke survivors (n=18) and HCPs (n=24) identified the need for an intervention that could be delivered at different time points within the rehabilitation pathway, tailored to individual needs and circumstances with training for HCPs delivering the intervention. Intervention delivery was considered feasible within local community stroke services. The target behaviours for the intervention were physical activity and sedentary behaviour of stroke survivors. Assessment of acceptability and usability with 11 HCPs and 21 stroke survivors/relatives identified issues around self-monitoring tools; the need for a repository of local services for physical activity; and the need for face-to-face feedback provision to HCPs following delivery of the intervention for optimisation purposes. Face-to-face training for HCPs was delivered to support faithful delivery of the intervention within community settings. A feasibility study protocol was designed to evaluate the intervention.ConclusionsA systematic development process using intervention mapping resulted in a multi-faceted evidence- and theory-informed intervention (Physical Activity Routines After Stroke - PARAS) for delivery by community stroke rehabilitation teams. Trial registration: Trial identifier: ISRCTN35516780, date of registration: 24/10/2018, URL http://www.isrctn.com/ISRCTN35516780
Quality of Life and Health Status of Adults With Congenital Heart Disease in Vietnam: A Cross-Sectional Study
Authors: Truong Thanh-Huong , Kim Ngoc-Thanh , Nguyen Mai-Ngoc Thi , Do Doan-Loi , Nguyen Hong Thi , Le Thanh-Tung , Le Hong-An 
Published: February 2021

Abstract
Background: Little is known about the quality of life (QOL) and health status of adults with congenital heart disease (CHD) in developing countries. Therefore, this study aimed to describe the QOL and health status of adults with CHD and investigate the association between QOL and biological and social characteristics of these patients in Vietnam.Methods: A cross-sectional study was performed among 109 adults with CHD, hospitalised in the Vietnam National Heart Institute, between June 2019 and December 2019. Validated instruments to assess QOL and health status describing patient-reported outcomes were used, including the EuroQOL-5 Dimensions-5 Level, Satisfaction with Life Scale and Hospital Anxiety and Depression Scale.Results: The overall mean scores on the EuroQOL-descriptive system (EQ-DS) and the EuroQOL visual analogue scale (EQ-VAS) were 0.792 (SD = 0.122, 95% confidence interval, CI 0.769–0.815) and 66.3 (SD = 12.5, 95% CI 63.9–68.7), respectively. Symptoms of anxiety and depression were common among adults with CHD (18.7%, n = 20 and 11%, n = 12; respectively). Stratified multivariate logistic regression revealed: poor QOL using the EQ-DS, and that anxiety related to suffering from a complex CHD/ pulmonary artery hypertension (PAH) (Odds Ratio, OR = 4.55, 95% CI: 1.26–16.4, p = 0.021 and OR = 4.19, 95% CI 1.2–14.56, p = 0.024; respectively); poor QOL using the EQ-VAS, anxiety, and depression related to being unemployed/ unstable employment (OR = 4.16, 95% CI 1.64–10.56, p = 0.003; OR = 3.63, 95% CI 1.23–10.72, p = 0.02 and OR = 7.68, 95% CI 2.09–28.25, p = 0.002; respectively); and life dissatisfaction related to being unmarried (OR = 4.63, 95% CI 1.2–17.86, p = 0.026).Conclusions: Adults with CHD in Vietnam experienced low QOL, and high levels of anxiety and depression. Poor QOL and psychological problems were related to being female, unmarried, low educational level, unemployed/ unstable employ, and complex CHD/ PAH.