bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Chemotherapy-Induced Nausea and Vomiting and Antiemetic Guideline Compliance in Chinese Real Clinical Setting: A Cross-Sectional Multicenter Survey
Authors: shi yanxia , Xue Cong , Li Lu , Xia Qing , An Xin , Li Haifeng , Zhang Lulu , Hou Mei , Yuan Xianglin , Chen Xi , Zhang Yiping , Zhao Lingdi , Shi Yuankai , Hu Xichun , Yang Shune , Cheng Jing , Luo Yi , Liang Hui , Zou Qingfeng , Han Zhengxiang , Gu Kangsheng , Niu Zuoxing , Gao Yuhuan , Xia Li , Yang Runxiang , Xiong Jianping , Bu Qing , Jiang Xiaodong , Xie Xiaodong , Sun Tao , Zhang Qingyuan , Ma Shoucheng , Tan Shisheng , Li Miao , Wang Ningju , Wang Xiumei , Ba Yi , Feng Jifeng , Jiang Wenqi 
Published: November 2021

Abstract
Background

This survey aims to investigate the incidence of chemotherapy-induced nausea and vomiting (CINV) in Chinese real clinical setting and evaluate the effect of guideline-consistent CINV prophylaxis (GCCP) and guideline-inconsistent CINV prophylaxis (GICP) on incidence of complete response (CR) of CINV.
Materials and Methods

A cross-sectional nationwide multicenter study assessing the guideline consistency and CINV incidence of patients was conducted at a total of 32 large medical centers from 26 provinces across the west,east༌northeast and middle part of China between April and May 2021.
Result

Data for 2964 patients were analyzed. Patients treated with moderately emetogenic chemotherapy (MEC) were more prone to experience CINV during the acute phase compared to those receiving highly emetogenic chemotherapy (HEC); patients receiving low or minimally emetogenic chemotherapy (L/mEC) were least likely to experience CINV during the overall phase among the whole study population. The prevalence of GCCP was 29.2% in the whole study population, and 13.6%, 35.7% and 45.1% for the patients receiving HEC, MEC and L/mEC, respectively. For patients receiving HEC and MEC, GCCP increased incidence of CR during both delayed and overall phases. For those receiving L/mEC and GICP, incidence of CR was not higher than that of patients receiving L/mEC and GCCP.
Conclusion

This study revealed Chinese CINV status, the prevalence of GCCP in the real clinical setting and the association between GCCP and CR rate for the first time. The findings indicate that prescribing antiemetics in compliance with guidelines for all patients receiving chemotherapy is strongly suggested.
Excessive Consumption of the Sugar Rich Longan Fruit Promoted the Development of Non-alcoholic Fatty Liver Disease via Mediating Gut Dysbiosis
Authors: Huang Huimin , Li Mingxing , Wang Yi , Wu Xiaoxiao , Wang Qin , Shen Jing , Xiao Zhangang , Zhao Yueshui , Du Fukuan , Li Jing , Chen Yu , Wu Zhigui , Yang Yifei , Liu Lin , Cho Chi Hin , He Yisheng , Wu Xu , Xiao Jianbo 
Published: November 2021

Abstract
Background: Controversy exists as towards the association of excessive fruits intake and certain disease risks. Longan is an edible fruit rich in high levels of fructose, glucose and sucrose. The aim of this study was to provide direct evidence on the effect of the sugar rich longan fruit on the development of non-alcoholic fatty liver disease (NAFLD). Chemical profiling of longan fruit was conducted using LC-HRMS and HPLC-ELSD.Results: Longan extracts at the doses of 4.0 g/kg, 8.0 and 16.0 g/kg were orally administered for 4 weeks to healthy C57BL/6J mice or to C57BL/6J mice fed with a HFD diet. Fecal microbiome was analyzed by 16S rRNA sequencing. The amounts of short chain fatty acids (SCFAs) in colonic contents were determined by GC-MS. Colon and liver tissues were used for histopathological examination after H&E, Masson’s trichrome, and Oil-red O staining. ELISA method was used for biochemical analysis in serum. In mice fed a normal diet, repeated longan intake for 4 weeks at excess doses (8 or 16 g/kg), but not the normal dose (4 g/kg), promoted inflammation and gut dysbiosis-like status and reduced short-chain fatty acids (SCFAs) production. In high-fat diet (HFD)-fed mice, longan intake at 4 g/kg hardly influenced the NAFLD development. In contrast, excess longan intake (8 or 16 g/kg) promoted NAFLD pathogenesis, including increased abnormality in hepatic indices, elevated inflammation, and gut permeability associated with more severe liver steatosis and fibrosis. Moreover, the exacerbated pathogenic markers were positively correlated with increased blood sugar, aggravated HFD-associated microbial dysbiosis. Conclusions: Effects mediated by excess longan intake resembled that of equivalent free sugars supplementation, suggesting that high level of free sugars in fruits contributed to the promotion of NAFLD development as demonstrated in case of excessive longan intake.
Potential Roles of Long Non-coding RNAs in Regulating Cell Proliferation, Invasion, and Metastasis in Ovarian Serous Cystadenocarcinoma
Authors: Kan Mujie , Zhang Housen , Dong Chengya , Xu Tianmin , Li Qi 
Published: November 2021

Abstract
Background: Ovarian serous cystadenocarcinoma (OSC) is the most common gynecological malignancy. Long non-coding RNAs (lncRNAs) are aberrantly expressed in many cancers and involved in cell proliferation, apoptosis, angiogenesis, and invasion. Here, we investigated the functional roles of lncRNAs in OSC in detail.Methods: We analyzed a cohort of exon microarray datasets from The Cancer Genome Atlas and used differentially expressed lncRNAs and mRNAs to construct an lncRNA-mRNA co-expression network. Distinct lncRNAs were classified into lincRNA, enhancer-like lncRNAs, or antisense lncRNAs. Biological functions for lncRNAs were predicted according to the lncRNA-mRNA network and genomic adjacency by KEGG pathway analysis. A transcription factor (TF)-lncRNA regulatory network was constructed by integrating lncRNA molecular profiles and TF binding information. Results: We identified 2,939 lncRNAs and 2,766 mRNAs that were differentially expressed between OSC and normal ovary tissues. The 67 lncRNAs in the lncRNA-mRNA network, 23 lincRNAs, 19 antisense lncRNAs, and four enhancer-like lncRNAs were involved in cell proliferation, invasion, and metastasis. The TFs ING4, TTF-1, RUSH-l alpha, Kaiso, and STAT1 targeted regulation of lncRNAs in the pathological processes of OSC. Expression of 10 lncRNAs and mRNAs, as well as SOS1, ITGB1, and BIRC2 mRNAs with their identified lncRNAs were verified by qRT-PCR in OSC tissues. Conclusions: We predicted the biological functions of many lncRNAs, which may serve as diagnostic and prognostic biomarkers as well as therapeutic targets in OSC.
Stable Isotope and Hydrochemical Evolution of Groundwater in Mining Area of the Changzhi Basin, Northern China
Authors: Zhang Chunchao , Li Xiangquan , Ma Jianfei , Wang Zhenxing , Hou Xinwei 
Published: November 2021

Abstract
The Changzhi Basin of China is an economically and ecologically important area with intensive human activities. To foster the sustainable development of groundwater resources and the economy, a total of 117 groundwater samples were collected in shallow and deep aquifers, including 91 2H and 18O isotope samples, to improved understanding of the natural geochemical processes and the impacts of anthropogenic activities on the groundwater chemistry. Synthetical application of the stable isotopes, Piper diagram, Gibbs diagram, ionic ratios and saturation indices to data analysis led to identification of hydrochemical zones for both aquifers from west to east of the basin. Isotopic analyses suggested that the groundwater recharge mainly comes from infiltration of rain water, hydraulic interaction between surface water and shallow groundwater, and lateral recharge from fissure water at the edge of the basin. The predominant natural geochemical processes include mineral dissolution in conjunction with the cation exchange. The excess deuterium method revealed that mineral dissolution contributed 81%–98% to the salinity of shallow groundwater and 84%–98% to the salinity of deep groundwater. Anthropogenic activities are secondary contributions to the hydrochemical evolution with fertilizer application, human waste and sewage discharges causing an increase in NO3-N content and coal mining activities affecting the ion content of Na+, Cl-, SO42-, and HCO3- in the groundwater.
Analysis of long-term climatic changes at Hodeidah-Yemen during the period between 1984 and 2019
Authors: Iraqi Abkar Ali , AbdAlla AbdAlla Mohammed 
Published: November 2021

Abstract
Yemen is one of the Arab country that is vulnerable to climate changes, and this is clear from the indicators of impact on water resources, coastal zone environments, etc. This work focuses on studying the climatic variability at Hodeidah city-Yemen during the period between 1984 and 2019. This study aimed to characterize trends in mean monthly, seasonal and annual temperature. To attain these objectives the collected data were analyzed using both parametric (linear regression) and non-parametric (Mann–Kendall, Spearman and Sen's slope estimator tests) methods to detect the trend and the magnitudes of rates of changes of temperature over time. Analysis of data indicates clear climatic fluctuations of temperature. The annual means of temperature during the period of study were varied between 26.9°C and 30.1°C. The warmest years were observed during the more recent years of the study period ( 2005 to 2018). The increasing rate of annual temperature is about + 0.075°C /year, + 0.37°C/5year, + 0.75°C/decade ,+2.53°C, over the whole period of study(1985 to 2019), + 3.7°C/50 year and increase to + 4.85°C in 2050. On a monthly timescale, there are similar magnitudes of rates of change from December to September with highest rates in October and November. The results also showed that most months and seasons have significant positive trends in temperature and (Z-α/2) values of the MK Test > 1.96 and positive value of Sen’s slope estimator indicates significant an increasing trend towards warmer years. Anomalies of temperature confirm significant increasing trends towards warmer years (2000s to 2019).
Distribution and Identification of Mycobacterium tuberculosis Lineage in Kashgar Prefecture
Authors: Xu Ai-Min , He Chuan-Jiang , Chen Xiang , Li Li , Abuduaini AniKiz , Tuerxun Zureguli , Sha Yin-Zhong , Kaisaier Aihemaitijiang , Peng Hong-Mei , Zhen Ya-Hui , Zhang Su-Jie , Xu Jing-Ran , Zou Xiao-Guang 
Published: November 2021

Abstract
Objectives
In order to understand the composition of Mycobacterium tuberculosis(M.tb) lineage and find specific tags to distinguish lineage of the M.tb in Kashgar prefecture, so as to provide a basis for the prevention of tuberculosis in this area.
Methods
Whole genome sequencing (WGS) of M.tb clinical strains (161 cases) was conducted. The phylogenetic tree was constructed by Maximum Likelihood (ML) on the basis of single nucleotide polymorphisms (SNPs) and verified via principal component analysis (PCA). The composition structure of M.tb in different regions was analyzed by combining geographic information.
Results
The M.tb clinical strains were composed of lineage 2 (73/161, 45.34%), lineage 3 (52/161, 32.30%) and lineage 4 (36/161, 22.36%) in Kashgar prefecture. And the 3 lineages were subdivided into 11 sublineages, among which lineage 2 includes lineage 2.2.2/Asia Ancestral 1(9/73, 12.33%),lineage 2.2.1-Asia Ancestral 2(9/73, 12.33%)༌lineage 2.2.1-Asia Ancestral 3(18/73, 24.66%) and lineage 2.2.1-Modern Beijing(39/73, 53.42%).Lineage 3 includes lineage 3.2(14/52, 26.92%)and lineage 3.3(38/52, 73.08%)༌lineage 4 includes lineage 4.1(3/36, 8.33%)༌lineage 4.2(2/36, 5.66%)༌lineage 4.4.2(1/36, 2.78%)༌lineage 4.5(28/36, 77.78%) and lineage 4.8(2/36, 5.66%)༌all of which were consistent with the PCA results. Among the identified 21438 SNPs ,there are 136 markers proposed to discriminate known circulating strains. Reconstruction of a phylogenetic tree using the 136 SNPs for all 161 samples resulted in a tree with the same number of delineated clades. Based on geographical location analysis, the composition of Lineage 2 in Kashgar prefecture (45.34%) is lower than other regions level in China(54.35%-90.27%), and the composition of Lineage 3 (32.30%)is much higher than other regions level in China (0.92%-2.01%), but it is lower than the bordering Pakistan (70.40%).
Conclusion
In summary, M.tb clinical strains from Kashgar prefecture were identifed 3 lineages and 11 sublineages, with 136 Branch-Specific SNP. Kashgar borders countries with a high incidence of tuberculosis such as Pakistan and India, resulting in a large difference between the M.tb lineage and sublineage distribution in this region and other provinces in China. This research provides a theoretical basis for the prevention and control of tuberculosis in Xinjiang.
The Prevalence of Human Immunodeficiency Virus Infection among Voluntary Blood Donors in Mainland China: A Systematic Review and Meta-Analysis
Authors: Gao Zhan , Li Yuhui , Zhiyang Liu , Huang Yang , He Miao 
Published: November 2021

Abstract
BACKGROUND: The epidemic of Human Immunodeficiency Virus (HIV) in China has been increasing. Despite the implementation of screening strategies, there was still the residual risk of transfusion-transmitted HIV. This study investigated the HIV prevalence among voluntary blood donors during the past 24 years in order to characterize the epidemiology of HIV.METHODS: The literature concerning the HIV screening reactive rate and prevalence in Chinese voluntary blood donors were collected through the systematic searching of four electronic databases. After integrating data, following the Preferred Reporting of Items for Systematic Reviews and Meta-Analyses guidelines, data manipulation and statistical analyses were conducted by Stata 12.0. We investigated the trend of HIV prevalence (and 95% CIs) and related epidemiological characteristics among blood donors in mainland China.RESULTS: The results indicated that HIV prevalence was 0.0165% (95% CI, 0.0155%-0.0176%) with a remarkable rise, which varied from 2000 (0.0034%) to 2017 (0.0247%). Importantly, the heterogeneity was found in occupations and Donation frequency. Additionally, the HIV prevalence were significantly higher among male donors than among female donors.CONCLUSIONS: Our results indicated obvious difference between HIV screening reactive rate and HIV prevalence in Chinese blood donors and HIV screening reactive rate cannot reflect reality of HIV infection. In this study, continuous increased trend of HIV prevalence demonstrates extended residual risk of blood transfusion, and the whole society is supposed to pay close attention to HIV infection.
Identification of Foods To Monitor The Sodium Content of Processed Foods for Developing a Sodium Reduction Program in The Philippines
Authors: Amarra Maria Sofia , Capanzana Mario , Gironella Glen , Reyes Francisco de los 
Published: November 2021

Abstract
Background

In response to the global target for reduction in salt intake, several countries have implemented population sodium reduction strategies. These strategies include identification of major sources of sodium in the diet and reformulation of a set number of products available on the market. This study aimed to identify processed foods that can be targeted for reformulation and whose sodium content can be monitored over time in order to reduce sodium intake in the Philippines. The objectives were to: 1) Estimate per capita sodium intake from minimally processed and processed food groups by income quintile and urban/rural location; 2) Identify foods that contribute to the variance in per capita sodium intake that can be used as indicators for monitoring the sodium content of Philippine processed foods. One-day household food weighing data covering 4880 households from the 2008 National Nutrition Survey was used. Per capita sodium consumption from processed and minimally processed food categories and percentiles of sodium intake from these categories by income quintile and urban/rural location were obtained. The percentage contribution of different food categories to mean per capita sodium intake was calculated. Specific foods that contributed to the variance in sodium intake among Filipinos were identified.
Results

Foods which significantly accounted for 99.4% of the variance in sodium intake were 13 types of processed foods and 2 types of minimally processed foods. The category Processed Soup, Sauces, and Flavor Enhancers contributed the greatest proportion to per capita sodium intake. Specific processed foods that contributed to the variance in per capita sodium intake were instant noodles, traditional fermented condiments and sauces, dried and processed meat, fish, and poultry products, salted eggs, white bread and pan de sal (a traditional Filipino bread), wheat and egg noodles, crispy cereal chips and extruded snacks, butter and margarine, cheese, and chocolate-based beverages.
Conclusion

Identifying processed foods that significantly contribute to sodium intake, followed by reformulating and monitoring the sodium content of these foods over time should be considered as one strategy to reduce sodium intake in the Philippines.
Optimizing Photoautotrophic Micropropagation Conditions for Ginger
Authors: Zhou Jie , Guo Fengling , Qi Chuangdong , Fu Jiaping , Xiao Ying , Wu Jinping 
Published: November 2021

Abstract
Ginger (Zingiber officinale), a member of the Zingiberaceae family, is a commonly available spice and medicinal plant. This study aimed to develop an alternative conventional micropropagation using photomixotrophic micropropagation for ginger. Rootless ginger tissue culture plantlets were initiated in culture vessels grown a chamber maintained under a 16 h/day photoperiod with an intensity of 60 μE m-2 s-1 from cool white fluorescent lamps at 25 ± 2℃ with an air relative humidity of 60 ± 5%. Photoautotrophic micropropagation of ginger was optimized using vermiculite + peat (1:1(v/v)) as substrate combined with MS + 0.5 mg/L NAA + 0.1% Metalaxyl-M·Hymexazol + 80% relative humidity (RH). After 40 days of culture, in-vitro ginger seedlings were successfully bred with a rooting rate of 100.0%.
How Can Advance Care Planning Support Hope in Patients with Advanced Cancer and Their Families: A Qualitative Study as Part of the International ACTION Trial
Authors: Kodba-Čeh Hana , Lunder Urška , Bulli Francesco , Caswell Glenys , Delden Johannes J. M. van , Kars Marijke C. , Korfage Ida J. , Miccinesi Guido , Rietjens Judith A. C. , Seymour Jane , Toccafondi Alessandro , Zwakman Marieke , Pollock Kristian 
Published: November 2021

Abstract
Purpose: Clinicians’ fears of taking away patients’ hope is one of the barriers to advance care planning (ACP). Barriers to ACP were extensively studied, however, research on how advance care planning potentially supports hope is scarce. The concept of hope in the terminally ill is context-specific and difficult to operationalize. This study aimed to explore aspects of hope supported by structured ACP conversations.Methods: In an international qualitative study using in-depth interviews we explored ACP experiences of patients with advanced cancer and their personal representatives (PRs) within the cluster-randomized control ACTION trial. An established sensitizing concept of hope in terminal illness (with several themes such as facilitating control, interpersonal relationships etc.) served as a point of reference in identifying attributes of hope supported by ACP conversations. A thematic analysis was performed on segments of text relevant to answer the research question.Results: Twenty patients with advanced lung or colorectal cancer and 17 personal representatives from Italy, the Netherlands, Slovenia and the United Kingdom were interviewed after participation in structured ACP conversations. Three potential mechanisms through which hope may be supported were recognized for patients and their PRs: (I) achieving a greater sense of empowerment for the future; (II) experiencing participation in ACP conversations as an act of mutual care; (III) strengthening shared confidence and partnership. In addition, our results suggest that participants’ hopes for cure or longevity persist after ACP conversations. Conclusion: We identified various potentially hope supporting mechanisms of ACP conversations cultivating agency, mutuality and interdependency between people involved.
Therapeutic and Preventive Effects of Morphine Against Leishmania Major and Evaluation the Expression of TLRs and Cytokines in Infected Macrophages in Vitro and in BALB/c Mice
Authors: Ebrahimisadr Parisa , Ghaffarifar Fatemeh , Jabari Javad , Horton John , Sharifi Zohreh , Dalimi Abdolhossein , Dayer Mohammad Saaid 
Published: November 2021

Abstract
Purpose: Toll-Like Receptors (TLRs) and cytokines play key roles in infection control. They also enhance phagocytosis and killing of parasites. Morphine can modify host immunity and defense against infectious diseases. Methods: In this study, we assessed Therapeutic and preventive effects of morphine against Leishmania major and then we evaluated the expression of TLRs and pro and anti-inflamatory cytokines in both healthy macrophages and those infected with Leishmania major in vitro and in BALB/c mice. Results: Morphine showed preventive effect and no lesions were observed in the group that was taken morphine before being challenged with promastigotes. TLR2 expression decreased in drug-treated healthy macrophages, whereas TLR4 expression increased. TLR7 expression decreased in healthy macrophages. TLR9 expression was the highest in the groups treated with morphine in infected macrophages. Our findings revealed that healthy macrophages produce higher TNFα and lower IL6; the infected macrophages show a reverse pattern by producing higher IL6 and lower TNFα. We found that treatment with morphine strengthen defensive reactions against leishmaniasis. In mouse macrophages, the highest level of TLR9 expression was induced by morphine. Conclusion: TLR9 has critical role for recognition and control of microbial infection. No lesions were developed in mice treated with morphine before challenge which suggests a protective role for morphine in leishmaniasis. The positive role of morphine in decreasing IL-10 expression and increasing the expression of inflammatory cytokines such as TNF-α and therefore its preventing role in Leishmania disease.
Orthogonal Constrained Meta Heuristic Adaptive Multi-View Clustering Over Multi Labeled Categorical Data Analysis
Authors: Kolli Srinivas , Sreed M 
Published: November 2021

Abstract
In data mining, clustering is the one of the efficient research concept in real time data analysis, evaluation of attribute representation in clustering is main issue in artificial intelligence related research areas. Multi labeled clustering gives high amount of valuable data, which describes the evaluation and representation of attribute be the trending concept in multi labeled categorical data analysis. Multi dimensional clustering is combined complementary data from different dimensions to provide efficient clustering results in various conditions. Different multi view clustering techniques are proposed traditionally but they can give output as single clustering with input data. Because of multiplicity, multi dimensional data can have different grouping data which are reasonable consist perspective attributes. So how to find measurable and reasonable cluster results which are represented in multi view labeled data is still challenging task, so that in this paper, we propose a novel approach i.e. Orthogonal Constrained Meta Heuristic Adaptive Multi-View Clustering (OCMHAMVC) to represent data as a cluster with different categories. Based on multi labeled data, first proposed approach evaluates low dimensional data using optimized matrix factorization (OMF) method and clusters the similar labeled sample data into prototype cluster of dimensional data. After that we represent data in desirable orthonormality constrained view of data using adaptive heuristic to combine complementary data from different dimensions, also provide complexity in computational analysis of data representation. Experimental results of proposed approach applied on high amount of multi view data gives scalable and efficient performance with comparison to traditional multi view related clustering approaches.