bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response thanTP53Mutation Status
Authors: Fujihara Kenji M. , Corrales Benitez Mariana , Cabalag Carlos S. , Zhang Bonnie Z. , Ko Hyun S. , Liu David S. , Simpson Kaylene J. , Haupt Ygal , Lipton Lara , Haupt Sue , Phillips Wayne A. , Clemons Nicholas J. 
Published: July 2021

AbstractAPR-246 (eprenetapopt) is in clinical development with a focus on hematologic malignancies and is promoted as a mutant-p53 reactivation therapy. Currently, the detection of at least one TP53 mutation is an inclusion criterion for patient selection into most APR-246 clinical trials. Preliminary results from our phase Ib/II clinical trial investigating APR-246 combined with doublet chemotherapy [cisplatin and 5-fluorouracil (5-FU)] in metastatic esophageal cancer, together with previous preclinical studies, indicate that TP53 mutation status alone may not be a sufficient biomarker for APR-246 response. This study aims to identify a robust biomarker for response to APR-246. Correlation analysis of the PRIMA-1 activity (lead compound to APR-246) with mutational status, gene expression, protein expression, and metabolite abundance across over 700 cancer cell lines (CCL) was performed. Functional validation and a boutique siRNA screen of over 850 redox-related genes were also conducted. TP53 mutation status was not consistently predictive of response to APR-246. The expression of SLC7A11, the cystine/glutamate transporter, was identified as a superior determinant of response to APR-246. Genetic regulators of SLC7A11, including ATF4, MDM2, wild-type p53, and c-Myc, were confirmed to also regulate cancer-cell sensitivity to APR-246. In conclusion, SLC7A11 expression is a broadly applicable determinant of sensitivity to APR-246 across cancer and should be utilized as the key predictive biomarker to stratify patients for future clinical investigation of APR-246.
Modeling virus spread on a network using NetLogo for optimum network management
Authors: Alimboyong Catherine R. 
Published: July 2021

<span>The infections in computer networks are complex. Its spread is analogous to a contagious disease which can cause destruction within a few seconds. Viruses in a computer or computer networks can spread rapidly by various means such as access to online social networking sites like twitter, Facebook, and opening of email attachments. Thus, infections can go from being little dangerous to significantly harmful for a network. This paper proposed a simulation model that can predict the propagation of virus including the trend and the average infection rate using NetLogo software. Observed and simulated data sets were validated using chi-square tests. Results of the experiment have demonstrated accurate performance of the proposed model. The model could be very helpful for network administrators in mitigating the virus propagation and obstruct the spread of computer virus other than the usual prevention scheme particularly the use of antivirus software and inclusion of firewall security. </span>
Semantic feature extraction method for hyperspectral crop classification
Authors: Girish Baabu M. C. , C. Padma M. 
Published: July 2021

<span>Hyperspectral imaging (HSI) is composed of several hundred of narrow bands (NB) with high spectral correlation and is widely used in crop classification; thus induces time and space complexity, resulting in high computational overhead and Hughes phenomenon in processing these images. Dimensional reduction technique such as band selection and feature extraction plays an important part in enhancing performance of hyperspectral image classification. However, existing method are not efficient when put forth in noisy and mixed pixel environment with dynamic illumination and climatic condition. Here the proposed Sematic Feature Representation based HSI (SFR-HSI) crop classification method first employ Image Fusion (IF) method for finding meaningful features from raw HSI spectrally. Second, to extract inherent features that keeps spatially meaningful representation of different crops by eliminating shading elements. Then, the meaningful feature set are used for training using Support vector machine (SVM). Experiment outcome shows proposed HSI crop classification model achieves much better accuracies and Kappa coefficient performance. </span>
Disparity in the Setting of Incident Heart Failure Diagnosis
Authors: Sandhu Alexander T. , Tisdale Rebecca L. , Rodriguez Fatima , Stafford Randall S. , Maron David J. , Hernandez-Boussard Tina , Lewis Eldrin , Heidenreich Paul A. 
Published: July 2021

Background:
Early heart failure (HF) recognition can reduce morbidity, yet HF is often initially diagnosed only after a patient clinically worsens. We sought to identify characteristics that predict diagnosis in the acute care setting versus the outpatient setting.

Methods:
We estimated the proportion of incident HF diagnosed in the acute care setting (inpatient hospital or emergency department) versus outpatient setting based on diagnostic codes from a claims database covering commercial insurance and Medicare Advantage between 2003 and 2019. After excluding new-onset HF potentially caused by a concurrent acute cause (eg, acute myocardial infarction), we identified demographic, clinical, and socioeconomic predictors of diagnosis setting. Patients were linked to their primary care clinicians to evaluate diagnosis setting variation across clinicians.

Results:
Of 959 438 patients with new HF, 38% were diagnosed in acute care. Of these, 46% had potential HF symptoms in the prior 6 months. Over time, the relative odds of acute care diagnosis increased by 3.2% annually after adjustment for patient characteristics (95% CI, 3.1%–3.3%). Acute care diagnosis setting was more likely for women compared with men (adjusted odds ratio, 1.11 [95% CI, 1.10–1.12]) and for Black patients compared with White patients (adjusted odds ratio, 1.18 [95% CI, 1.16–1.19]). The proportion of acute care diagnosis varied substantially (interquartile range: 24%–39%) among clinicians after adjusting for patient-level risk factors.

Conclusions:
A large proportion of first HF diagnoses occur in the acute care setting, particularly among women and Black patients, yet many had potential HF symptoms in the months before acute care visits. These results raise concerns that many HF diagnoses are missed in the outpatient setting. Earlier diagnosis could allow for timelier high-value interventions, addressing disparities and reducing the progression of HF.
Coast Guard Law of the People’s Republic of China and Its Implications in International Law
Authors: Liu Chen-Hong , Xu Zhang , Chang Yen-Chiang 
Published: July 2021

Abstract
In January 2019, the People’s Armed Police set up a working group to draft the Coast Guard Law of the People’s Republic of China. The 13th National People’s Congress Standing Committee concluded its twenty-fifth session and scrutiny of this draft law, which officially entered force on 1 February 2021. The Law is divided into 11 chapters and 80 articles, including but not limited to maritime security, maritime crime investigation, use of non-firearm and weapons, and international cooperation. This article outlines and analyses the Law, as well as focusing on its implications as a matter of international law.
Syriac Love Charms. Part I. The Recipe-Type
Authors: Cherkashina Anna , Lyavdansky Alexey 
Published: July 2021

Abstract
In this paper we consider 6 Syriac love charms and edit their original text and translation. All but two texts are published here for the first time. This is the first part of our inquiry, in which we consider one of the two types of Syriac love charms, the recipe-type. Among its primary characteristics is its extreme rarity in Syriac magic codices. Another prominent trait of this type, which makes these texts especially valuable, is that some of them contain ritual instructions which are exceedingly rare for Syriac charms as a whole, while others may contain what we call an allusion to it. Our assumption is that texts of this type reflect ancient magic practices originating in pre-Christian time, which are credibly attested in the texts belonging to other magic traditions of the Near East and Egypt.
Interpretation of the Precipitation Structure Contained in Polarimetric Radio Occultation Profiles Using Passive Microwave Satellite Observations
Authors: Turk F. Joseph , Padullés Ramon , Cardellach Estel , Ao Chi O. , Wang Kuo-Nung , Morabito David D. , de la Torre Juarez Manuel , Oyola Mayra , Hristova-Veleva Svetla , Neelin J. David 
Published: July 2021

AbstractObservationally, a major source of uncertainty in evaluation of climate models arises from the difficulty in obtaining globally distributed, fine scale profiles of temperature, pressure and water vapor, that probe through convective precipitating clouds, from the boundary layer to the upper levels of the free troposphere. In this manuscript, a two-year analysis of data from the Radio Occultations through Heavy Precipitation (ROHP) polarimetric RO demonstration mission onboard the Spanish PAZ spacecraft is presented. ROHP measures the difference in the differential propagation phase delay (Δ𝜙) between two orthogonal polarization receive states that is induced from the presence of non-spherically shaped hydrometeors along the Global Navigation Satellite System (GNSS) propagation path, complementing the standard RO thermodynamic profile. Since Δφ is a net path-accumulated depolarization and does not resolve the precipitation structure along the propagation path, orbital coincidences between ROHP and the Global Precipitation Measurement (GPM) constellation passive MW radiometers are identified to provides three-dimensional precipitation context to the RO thermodynamic profile. Passive MW-derived precipitation profiles are used to simulate the Δφalong the ROHP propagation paths. Comparison between the simulated and observed Δφare indicative of the ability of ROHP to detect threshold levels of ray path-averaged condensed water content, as well as to suggest possible inferences on the average ice phase hydrometeor non-sphericity. The use of the polarimetric RO vertical structure is demonstrated as a means to condition the lower tropospheric humidity by the top-most height of the associated convective cloud structure.
Psychological distress, loneliness, alcohol use and suicidality in New Zealanders with mental illness during a strict COVID-19 lockdown
Authors: Bell Caroline , Williman Jonathan , Beaglehole Ben , Stanley James , Jenkins Matthew , Gendall Philip , Rapsey Charlene , Every-Palmer Susanna 
Published: July 2021

Introduction: People with pre-existing mental health conditions may have been disproportionally impacted by the COVID-19 pandemic and associated public health restrictions. In this study, we compared psychological outcomes, experiences and sources of stress over the pandemic lockdown in New Zealanders with and without a previous diagnosis of mental illness. Methods: Two online surveys were conducted in New Zealand over the level 4 lockdown in April 2020 measuring psychological distress, anxiety, well-being, suicidality, alcohol use and subjective experiences. They included 3389 participants, of whom 18.4% reported having been previously diagnosed with a mental illness. Results: During the lockdown, people previously diagnosed with a mental illness had about twice the risk of reporting moderate-high levels of psychological distress (K10 ⩾ 12), at least moderate levels of anxiety (GAD-7 ⩾ 10) and poor well-being (WHO-5 ⩽ 12). They reported increased alcohol use and were about four times as likely to have experienced suicidal thoughts with 3% reporting having made a suicide attempt over the lockdown period. They reported less satisfaction with, and poorer relationships with people in their ‘bubble’, reduced social contacts and greater loneliness. They also reported higher levels of health and financial concerns. Conclusion: During the COVID-19 lockdown in New Zealand, people with a previous diagnosis of a mental illness were at increased risk of detrimental psychological outcomes. This highlights the importance of recognising this and the challenges people face in pandemics.
CHECK UP: A student-designed model for creating innovative patient education materials that your patients will actually use
Authors: Cory Megan M , Cory Kevin S , Osmani Wasif A , Young Staci , Lundh Rebecca 
Published: July 2021

Objective As appointments become more rushed, it is crucial that primary care clinicians consider new and effective ways to provide preventive health education to patients. Currently, patient education is often handouts printed from the electronic medical record system; however, these pieces of paper often do not have the desired impact. Well-established advertising methods reveal that repeated exposure is key in recall and swaying consumer decisions. The Creating Health Education for Constructive Knowledge in Underserved Populations (CHECK UP) Program is a medical student-led program that aims to improve patient recall of health information, health promoting behaviors and health outcomes by applying modified advertising concepts to the delivery of health education. Methods Patients were given large magnets containing health education information. These patients were interviewed 3–4 months afterwards to assess use and effectiveness of magnets as a means to provide health education. Results In total, 25 of the 28 patients given CHECK UP magnets agreed to participate. The majority of participants (23/25) kept the magnets and reported that they, as well as others in their households, see the magnets daily. All 23 participants recalled at least 1 health tip from 1 of the magnets. Conclusions The use of non-traditional materials for patient education allowed for repeated exposure and recall of health information. Consideration for modified use of evidence-based advertising and marketing strategies for the delivery of patient education may be an easy and effective way to provide information to patients outside of the clinical setting and promote health behavioral changes.
The dosing procedure that “makes the poison”: Comparing the effects of single versus cumulative alcohol administration methods on emotion recognition
Authors: Nagar Maayan , Weller Aron , Rabinovitz Sharon 
Published: July 2021

Background: Most people often consume alcohol cumulatively and gradually. Yet almost scientific knowledge about alcohol’s acute effects on cognition, behavior, and affect stems from laboratory studies that employ a single beverage administration procedure. Objective: This study tests the hypothesis that alcohol’s acute effects depend on both methods of administration and alcohol blood level. We introduce a new laboratory procedure for studying cumulative alcohol drinking and examine alcohol’s effects on emotion recognition as a function of both alcohol administration method and alcohol blood level. Methods: Participants were recruited for one of two studies. One study employed a between-subject design using a single alcoholic dose. Participants were randomly assigned to drink either placebo (0.00%), low (0.03%), moderate (0.06%), or high (0.09%) alcohol levels. The second study employed a within-subject design using a cumulative alcoholic administration method, in which each participant drank four drinks (placebo, followed by three alcoholic drinks). Both groups reached similar breath alcohol concentrations. In both studies, participants attended a single study session, in which emotion recognition was examined following alcohol administration. Results: Single alcoholic beverage administration method caused greater impairment in emotion recognition ability, specifically for anger, happiness, and fear, as compared with cumulative administration method, even though breath alcohol levels were similar in both conditions. Conclusions: This paper presents questions concerning the internal validity of previous laboratory studies that use a single beverage administration procedure. Insights into the effects of alcohol on behavior, as well as regarding our knowledge about models of addiction are presented.
Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults
Authors: Valenzuela-Narváez Rocío Violeta , Valenzuela-Narváez Daniel Raùl , Valenzuela-Narváez Daniel Alberto Oswaldo , Córdova-Noel María Elena , Mejía-Ruiz Cris Lisseth , Salcedo-Rodríguez Medalit Nieves , Gonzales-Aedo Oliver 
Published: July 2021

Objective The aim of this study was to evaluate periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults. Methods A total of 1159 adults aged 65 to 80 years and diagnosed with periodontal disease and CKD (stages 1, 2, and 3) were randomly selected for a cross-sectional study. Periodontal status was assessed using the Community Periodontal Index of Treatment Needs (CPITN) and CKD was staged using the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) guidelines. Results In patients with stage 1 CKD, the odds ratios (ORs) (95% confidence intervals [CIs]) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1.13 (0.83–1.55), 1.47 (1.13–1.81), 1, and 1, respectively. In patients with stage 2 CKD, the ORs (95% CIs) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1.49 (1.14–1.93), 1.37 (1.02–1.78), 3.07 (2.81–3.25), and 3.65 (3.49–3.71), respectively. In patients with stage 3 CKD, the ORs (95% CIs) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1, 1, 4.61 (4.47–5.21), and 5.23 (5.14–5.47), respectively. Conclusion The highest CPITN values (CPITN-3 and CPITN-4) were associated with CKD stages 2 and 3. Thus, periodontal disease may be associated with progression of CKD.
Unsupervised clustering analysis of data from an online community to identify lupus patient profiles with regards to treatment preferences
Authors: Testa Damien , Jourde-Chiche Noémie , Mancini Julien , Varriale Pasquale , Radoszycki Lise , Chiche Laurent 
Published: July 2021

Objective Lupus is a chronic complex autoimmune disease. Non-adherence to treatment can affect patient outcomes. Considering patients’ preferences into medical decisions may increase acceptance to their medication. The PREFERLUP study used unsupervised clustering analysis to identify profiles of patients with similar treatment preferences in an online community of French lupus patients. Methods An online survey was conducted in adult lupus patients from the Carenity community between August 2018 and April 2019. Multiple Correspondence Analysis (MCA) was used with three unsupervised clustering methods (hierarchical, kmeans and partitioning around medoids). Several indicators (measure of connectivity, Dunn index and Silhouette width) were used to select the best clustering algorithm and choose the number of clusters. Results The 268 participants were mostly female (96%), with a mean age of 44.3 years 83% fulfilled the American College of Rheumatology (ACR) self-reported diagnostic criteria for systemic lupus erythematosus. Overall, the preferred route of administration was oral (62%) and the most important feature of an ideal drug was a low risk of side-effects (32%). Hierarchical clustering identified three clusters. Cluster 1 (59%) comprised patients with few comorbidities and a poor ability to identify oncoming flares; 84% of these patients desired oral treatments with limited side-effects. Cluster 2 (13%) comprised younger patients, who had already participated in a clinical trial, were willing to use implants and valued the compatibility of treatments with pregnancy. Cluster 3 (28%) comprised patients with a longer lupus duration, poorer control of the disease and more comorbidities; these patients mainly valued implants and injections and expected a reduction of corticosteroid intake. Conclusions Different profiles of lupus patients were identified according to their drug preferences. These clusters could help physicians tailor their therapeutic proposals to take into account individual patient preferences, which could have a positive impact on treatment acceptance and then adherence. The study highlights the value of data acquired directly from patient communities.
Nasopharyngeal Tube and Functional Treatment in Pierre Robin Sequence: A Tertiary Clinical Experience From 150 Cases
Authors: Blanc Fabian , Harrewijn Inge , Duflos Claire , Maggiulli Frederica , Captier Guillaume 
Published: July 2021

Objectives: To describe the initial care practices for children with Pierre Robin sequence (PRS) and analyze the factors predicting the severity of the obstruction breathing disorders. Design: A retrospective single-center study of 150 children with PRS. Setting: Single tertiary care center, Regional Competence Center for the diagnosis and treatment of PRS. Patients: A total of 150 children with PRS consecutively followed between 1986 and 2017. Group 1 comprises children without specific respiratory management; group 2, children requiring prone positioning to alleviate their respiratory distress symptoms; and group 3, children requiring nasopharyngeal airway tube (NT) or nonconservative surgical treatment. Main outcome measures: Evolution and results of the initial treatment of PRS. Results: Forty-two percent (n = 63) were attributed to group 1, 39% (n = 50) to group 2, and 19% (n = 29) to group 3. Preterm birth, birth weight, or associated congenital malformations were not significantly different between the groups. However, the age of exclusive oral feeding was significantly different: 1 day (quartiles: 0-3) for group 1; 11 days (quartiles: 1-28) for group 2; 39 days (quartiles: 19-111) for group 3 ( P < .0001). Considering the NT, its use relieves the upper airway obstruction, assessed by a respiratory polygraphy, in 14 children. Conclusions: Nasopharyngeal airway tube has become our major first-line treatment, avoiding more complex procedures in most of the cases. The achievement of exclusive oral feeding seems to be a good predictor of the severity of respiratory symptoms in PRS.
Ultrasonographic assessment of the caudal vena cava diameter in cats during blood donation
Authors: Sänger Florian , Dorsch Roswitha , Hartmann Katrin , Dörfelt René 
Published: July 2021

Objectives Ultrasonography of the caudal vena cava (CVC) has been previously established to assess fluid status in dogs but not in cats. The aim of this study was to determine CVC diameter changes during feline blood donation. Methods Inter- and intra-observer variability were assessed in 11 client-owned cats. Minimal and maximal CVC diameters were assessed longitudinally in the subxiphoid view (SV) and right paralumbar view (PV), and transversely in the right hepatic intercostal view (HV). Eighteen client-owned, healthy, anaesthetised cats were evaluated during 21 blood donation procedures of 10 ml/kg in the same anatomical locations before (T0) and after (T1) blood donation, and after volume resuscitation with 30 ml/kg lactated Ringer’s solution (T2). The CVC index was calculated. Results Intra-observer variability was acceptable for all probe positions, except for the HV, whereas inter-observer variability was considered unacceptable for all probe positions. Complete measurements were obtained during 21 blood donations at T0, T1 and T2 at the SV, during 18/21 blood donations at the HV and during 16/21 blood donations at the PV. At the SV, the minimal CVC diameter between T1 and T2 ( P <0.001), and the maximal CVC diameter between T0 and T1 and between T1 and T2 ( P <0.001) were significantly different. At the HV, the minimal vertical diameter, maximal vertical diameter and minimal horizontal diameter were different between all timepoints ( P <0.001). The maximal horizontal diameter was different between T1 and T2 ( P = 0.002). At the PV, both diameters were different between all timepoints ( P <0.001). The CVC index was not different between timepoints. Conclusion and relevance Significant probe position dependent CVC diameter changes with marked overlap were observed before and after blood donation, and after fluid bolus. No absolute CVC diameter could be used to indicate hypovolaemia. Ultrasonographic assessment of the feline CVC is highly operator-dependent. The CVC index is not useful in cats.