bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating between Scylla and Charybdis: challenges and strategies for implementing guideline‐directed medical therapy in heart failure with reduced ejection fraction
Authors: Seferović Petar M. , Polovina Marija , Adlbrecht Christopher , Bělohlávek Jan , Chioncel Ovidiu , Goncalvesová Eva , Milinković Ivan , Grupper Avishay , Halmosi Róbert , Kamzola Ginta , Koskinas Konstantinos C. , Lopatin Yuri , Parkhomenko Alexander , Põder Pentti , Ristić Arsen D. , Šakalytė Gintarė , Trbušić Matias , Tundybayeva Meiramgul , Vrtovec Bojan , Yotov Yoto T. , Miličić Davor , Ponikowski Piotr , Metra Marco , Rosano Giuseppe , Coats Andrew J.S. 
Published: November 2021

AbstractGuideline‐directed medical therapy (GDMT) has the potential to reduce the risks of mortality and hospitalisation in patients with heart failure (HF) with reduced ejection fraction (HFrEF). However, real‐world data indicate that many patients with HFrEF do not receive optimised GDMT, which involves several different medications, many of which require up‐titration to target doses. There are many challenges to implementing GDMT, the most important being patient‐related factors (comorbidities, advanced age, frailty, cognitive impairment, poor adherence, low socioeconomic status), treatment‐related factors (intolerance, side‐effects) and healthcare‐related factors that influence availability and accessibility of HF care. Accordingly, international disparities in resources for HF management and limited public reimbursement of GDMT, coupled with clinical inertia for treatment intensification combine to hinder efforts to provide GDMT. In this review paper, authors aim to provide solutions based on available evidence, practical experience, and expert consensus on how to utilise evolving strategies, novel medications, and patient profiling to allow the more comprehensive uptake of GDMT. Authors discuss professional education, motivation, and training, as well as patient empowerment for self‐care as important tools to overcome clinical inertia and boost GDMT implementation. We provide evidence on how multidisciplinary care and institutional accreditation can be successfully used to increase prescription rates and adherence to GDMT. We consider the role of modern technologies in advancing professional and patient education and facilitating patient–provider communication. Finally, authors emphasise the role of novel drugs (especially sodium–glucose co‐transporter 2 inhibitors), and a tailored approach to drug management as evolving strategies for the more successful implementation of GDMT.
Microfluidic‐based nanoparticle synthesis and their potential applications
Authors: Khizar Sumera , Zine Nadia , Errachid Abdelhamid , Jaffrezic‐Renault Nicole , Elaissari Abdelhamid 
Published: November 2021

AbstractA lot of substantial innovation in advancement of microfluidic field in recent years to produce nanoparticle reveals a number of distinctive characteristics, for instance, compactness, controllability, fineness in process, and stability along with minimal reaction amount. Recently, a prompt development, as well as realization in the production of nanoparticles in microfluidic environment having dimension of micro to nanometers and constituents extending from metals, semiconductors to polymers, has been made. Microfluidics technology integrates fluid mechanics for the production of nanoparticles having exclusive with homogenous sizes, shapes, and morphology, which are utilized in several bioapplications such as biosciences, drug delivery, and healthcare including food engineering. Nanoparticles are usually well‐known for having fine and rough morphology because of their small dimensions including exceptional physical, biological, chemical, and optical properties. Though the orthodox procedures need huge instruments, costly autoclaves, use extra power, extraordinary heat loss, as well as take surplus time for synthesis. Additionally, this is fascinating to systematize, assimilate, in addition, to reduce traditional tools onto one platform to produce micro and nanoparticles. The synthesis of nanoparticles by microfluidics permits fast handling besides better efficacy of method utilizing the smallest components for process. Herein, we will focus on synthesis of nanoparticles by means of microfluidic devices intended for different bioapplications.
A Critical Review of the Availability, Reliability, and Ecological Relevance of Arctic Species Toxicity Tests for Use in Environmental Risk Assessment
Authors: Eldridge Rebecca J. , de Jourdan Benjamin P. , Hanson Mark L. 
Published: November 2021

Abstract
There is a pressing need to understand the impact of contaminants on Arctic ecosystems; however, most toxicity tests are based on temperate species, and there are issues with reliability and relevance of bioassays in general. Together this may result in an underestimation of harm to Arctic organisms and contribute to significant uncertainty in risk assessments. To help address these concerns, a critical review to assess reported effects for these species, quantify methodological and endpoint relevance gaps, and identify future research needs for testing was performed. We developed uniform criteria to score each study, allowing an objective comparison across experiments to quantify their reliability and relevance. We scored a total of 48 individual studies, capturing 39 tested compounds, 73 unique Arctic test species, and 95 distinct endpoints published from 1975 to 2021. Our analysis shows that of 253 test substance and species combinations scored (i.e., a unique toxicity test), 207 (82%) failed to meet at least one critical study criterion that contributes to data reliability for use in risk assessment. Arctic-focused toxicity testing needs to ensure that exposures can be analytically confirmed, include environmentally realistic exposure scenarios, and report test methods more thoroughly. Significant data gaps were identified as related to standardized toxicity testing with Arctic species, diversity of compounds tested with these organisms, and the inclusion of ecologically relevant sublethal and chronic endpoints assessed in Arctic toxicity testing. Overall, there needs to be ongoing improvement in test conduction and reporting in the scientific literature to support effective risk assessments in an Arctic context. Environ Toxicol Chem 2022;41:46–72. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Heterogeneous health effects of medical marijuana legalization: Evidence from young adults in the United States
Authors: Chay Junxing , Kim Seonghoon 
Published: November 2021

AbstractLegalizing marijuana for medical purposes is a longstanding debate. However, evidence of marijuana's health effects is limited, especially for young adults. We estimate the health impacts of medical marijuana laws (MML) in the U.S. among young adults aged 18–29 years using the difference‐in‐differences method and data from the Behavioral Risk Factors Surveillance System. We find that having MMLs with strict regulations generate health gains, but not in states with lax regulations. Our heterogeneity analysis results indicate that individuals with lower education attainments, with lower household income and without access to health insurance coverage gain more health benefits from MML with strict regulations than from MML with lax regulations. The findings suggest greater net health gains under strict controls concerning marijuana supply and access.
Genetic mutations of APOEε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease
Authors: Jabeen Komal , Rehman Kanwal , Akash Muhammad Sajid Hamid 
Published: November 2021

AbstractType 2 diabetes mellitus and Alzheimer's disease (AD), both are chronic and progressive diseases. Many cardiovascular and genetic risk factors are considered responsible for the development of AD and diabetes mellitus (DM). Genetic risk factor such as apolipoprotein E (APOE) plays a critical role in the progression of AD. Specifically, APOEε4 is genetically the strongest isoform associated with neuronal insulin deficiency, altered lipid homeostasis, and metabolism, decreased glucose uptake, impaired gray matter volume, and cerebrovascular functions. In this article, we have summarized the mechanisms of cardiovascular disturbances associated with AD and DM, impact of amyloid‐β aggregation, and neurofibrillary tangles formation in AD. Moreover, cardiovascular risk factors leading to insulin resistance (IR) and amyloid‐β aggregation are highlighted along with the effects of APOE risk alleles on cerebral, lipid, and cholesterol metabolism leading to CVD‐mediated IR. Correspondingly, the contribution of IR, genetic and cardiovascular risk factors in amyloid‐β aggregation, which may lead to the late onset of AD and DM, has been also discussed. In short, IR is related to significantly lower cerebral glucose metabolism, which sequentially forecasts poorer memory performance. Hence, there will be more chances for neural glucose intolerance and impairment of cognitive function in cardiac patients, particularly APOEε4 carriers having IR. Hence, this review provides a better understanding of the corresponding crosstalk among different pathways. This will help to investigate the rational application of preventive measures against IR and cognitive dysfunction, specifically in APOEε4 carriers' cardio‐metabolic patients.
Web‐based transcriptome analysis determines a sixteen‐gene signature and associated drugs on hearing loss patients: A bioinformatics approach
Authors: Lei Min , Zhang Dongdong , Sun Yixin , Zou Cong , Wang Yue , Hong Yongjun , Jiao Yanchao , Cai Chengfu 
Published: November 2021

AbstractBackgroundHearing loss is becoming more and more general. It may occur at all age and affect the language learning ability of children and trigger serious social problems.MethodsThe hearing loss differentially expressed genes (HL‐DEGs) were recognized through a comparison with healthy subjects. The Gene Ontology (GO) analysis was executed by DAVID. The reactome analysis of HL‐DEGs was performed by Clue‐GO. Next, we used STRING, an online website, to identify crucial protein‐protein interactions among HL‐DEGs. Cytoscape software was employed to construct a protein‐protein interaction network. MCODE, a plug‐in of the Cytoscape software, was used for module analysis. Finally, we used DGIdb database to ascertain the targeted drugs for MCODE genes.ResultsFour hundred four HL‐DEGs were identified, among which the most up‐regulated 10 genes were AL008707.1, SDR42E1P5, BX005040.1, AL671883.2, MT1XP1, AC016957.1, U2AF1L5, XIST, DAAM2, and ADAMTS2, and the most down‐regulated 10 genes were ALOX15, PRSS33, IL5RA, SMPD3, IGHV1‐2, IGLV3‐9, RHOXF1P1, CACNG6, MYOM2, and RSAD2. Through STRING database and MCODE analysis, we finally got 16 MCODE genes. These genes can be regarded as hearing loss related genes. Through biological analysis, it is found that these genes are enriched in pathways related to apoptosis such as tumor necrosis factor. Among them, MMP8, LTF, ORM2, FOLR3, and TCN1 have corresponding targeted drugs. Foremost, MCODE genes should be investigated for its usefulness as a new biomarker for diagnosis and treatment.ConclusionIn summary, our study produced a sixteen‐gene signature and associated drugs that could be diagnosis and treatment of hearing loss patients.
Subjective well‐being and vulnerability related to problematic Internet use among university students with and without disabilities: A comparative study
Authors: Herruzo Carlos , Raya Trenas Antonio F. , Ruiz‐Olivares Rosario , Lucena Valentina , Herruzo Cabrera Javier , Pino María J. 
Published: November 2021

AbstractThis study aims to observe whether people with disabilities experience problematic Internet use (PIU) like that of young people without disabilities; to relate PIU to psychological distress in young disabled people and to determine whether these problems are similar to or different from those experienced by young people without disabilities. The sample comprised 408 university students with disabilities and 1386 university students without disabilities from several Spanish universities. PIU was evaluated using the Internet Addiction Test (IAT) and psychological distress was evaluated using the Clinical Outcomes in Routine Evaluation‐Outcome Measure (CORE‐OM). The group of university students with disabilities showed less PIU than the nondisabled students, but the worst scores in variables referencing psychological discomfort were found among those students with disabilities who also had PIU. Although the results are not completely generalizable, PIU is related to bigger problems in disabled people for whom it represents a higher risk than for people without disabilities.
Lifestyle‐ and comorbidity‐related factors for the prescription of proton pump inhibitors after Helicobacter pylori eradication in Japan
Authors: Shimada Furitsu , Endo Hiroyoshi , Takamori Ayako , Matsunaga Takuya , Fujimoto Shun , Shirai Shimpei , Kakiuchi Toshihiko , Akutagawa Takashi , Sakata Yasuhisa , Node Koichi , Yamanouchi Kohei , Nakamura Shotaro , Fujimoto Kazuma , Esaki Motohiro 
Published: November 2021

AbstractBackground and AimThe aim of the present study was to examine the lifestyle‐ and comorbidity‐related determinant factors of the prescription of proton pump inhibitors (PPIs) for patients in whom Helicobacter pylori has been eradicated, and to evaluate the relationship between PPI prescription and the severity of endoscopic esophagitis.MethodsThis retrospective study included patients who underwent H. pylori eradication from May 2012 to September 2016 at Saiseikai Karatsu Hospital. All patients received upper gastrointestinal endoscopy before H. pylori eradication. Patients with open peptic ulcers and/or malignant diseases were excluded, and a final total of 389 patients were evaluated. Medical records were reviewed to determine the prescription of PPIs after H. pylori eradication, lifestyle‐related factors, and comorbidities. Lifestyle‐related factors were confirmed by a questionnaire.ResultsPPIs were administered to 124 of 389 patients (31.9%). The only lifestyle‐related risk factor for the prescription of PPIs after H. pylori eradication was older age (P < 0.01). Hypertension increased the prescription of PPIs (P = 0.034). The prescription of PPIs was not influenced by the presence of grade A esophagitis, whereas the PPI prescription rate was significantly increased in patients with grades B/C/D endoscopic esophagitis (P < 0.01). The grade of chronic gastritis before H. pylori eradication had no effect on the prescription of PPIs.ConclusionThe lifestyle‐ and comorbidity‐related risk factors for the prescription of PPIs after H. pylori eradication were older age and hypertension, while mild endoscopic esophagitis had no influence on PPI prescription.
Remitting neuropsychiatric symptoms in COVID‐19 patients: Viral cause or drug effect?
Authors: Forero‐Peña David A. , Hernandez Matthew M. , Mozo Herrera Iriana Paola , Collado Espinal Iván Bolívar , Páez Paz Joselyn , Ferro Carlos , Flora‐Noda David M. , Maricuto Andrea L. , Velásquez Viledy L. , Camejo‐Avila Natasha A. , Sordillo Emilia M. , Delgado‐Noguera Lourdes A. , Perez‐Garcia Luis A. , Morantes Rodríguez Carlos G. , Landaeta María Eugenia , Paniz‐Mondolfi Alberto E. 
Published: November 2021

AbstractNumerous reports of neuropsychiatric symptoms highlighted the pathologic potential of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its relationship the onset and/or exacerbation of mental disease. However, coronavirus disease 2019 (COVID‐19) treatments, themselves, must be considered as potential catalysts for new‐onset neuropsychiatric symptoms in COVID‐19 patients. To date, immediate and long‐term neuropsychiatric complications following SARS‐CoV‐2 infection are currently unknown. Here we report on five patients with SARS‐CoV‐2 infection with possible associated neuropsychiatric involvement, following them clinically until resolution of their symptoms. We will also discuss the contributory roles of chloroquine and dexamethasone in these neuropsychiatric presentations.
Evolution of spike mutations following antibody treatment in two immunocompromised patients with persistent COVID‐19 infection
Authors: Bronstein Yotam , Adler Amos , Katash Haytham , Halutz Ora , Herishanu Yair , Levytskyi Katia 
Published: November 2021

AbstractImmunocompromised patients have an increased risk of persistent COVID‐19 disease. We report here the clinical course of two patients with hematologic malignancies hospitalized due to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. In both patients, viral evolution including new spike gene mutations that occurred following treatment with anti‐SARS‐CoV‐2 antibodies preparations, including convalescent plasma and bamlanivimab. These cases demonstrate the possibility of antibody‐resistant SARS‐CoV‐2 infections evolution in immunocompromised patients.
In situ and micro‐Raman spectroscopy for the identification of natural Sicilian zeolites
Authors: Finocchiaro Claudio , Coccato Alessia , Barone Germana , Bersani Danilo , Culka Adam , Fornasini Laura , Mazzoleni Paolo , Jehlička Jan , Rousaki Anastasia , Vandenabeele Peter 
Published: November 2021

AbstractZeolites are present in numerous outcrops of volcanites of different ages in Sicily (Italy). Some of these outcrops are important because they constitute the ideal genesis conditions of some of these minerals, which represent geological indicators of chemical and geothermal gradients involved during their formation. For this purpose, a group of zeolites coming from areas of the Ionian coast and Palagonia village (Eastern Sicily) was investigated by means of Raman spectroscopy. In the geological record, these areas have been influenced by intense volcanic events that produced mineralization of hydrothermal origin. Sicilian zeolite samples were analysed in situ using different mobile Raman apparatus, directly on the outcrops of Aci Castello and the nearby Lachea Island, or in local collections where they are preserved. Some of these samples have been then analysed using laboratory micro‐Raman to compare the results and identify the zeolite types. The strength and weakness points of each instrument have been highlighted. Often, the Raman spectra of zeolites are affected by broad fluorescence, making them of difficult interpretation. However, satisfying results were obtained with portable devices, whose identifications were confirmed by micro‐Raman, discerning zeolites of different groups, such as analcime, chabazite, natrolite and phillipsite. The use of portable instruments has demonstrated the possibility to obtain identification of zeolites and related minerals both on site and in the laboratory, whose results match with the geological setting of the considered areas.
Effect of transducer placements on thresholds in ears with an abnormal ear canal and severe conductive hearing loss
Authors: Nishimura Tadashi , Hosoi Hiroshi , Saito Osamu , Shimokura Ryota , Morimoto Chihiro , Okayasu Tadao , Kitahara Tadashi 
Published: November 2021

AbstractObjectivesProviding hearing compensation to patients with aural atresia is considerably challenging. Hearing aid transducers vibrating the aural cartilage (cartilage conduction; CC) have been devised, and hearing aids utilizing them (CC hearing aids) have quickly become a beneficial option for aural atresia in clinical applications. However, it remains unclear which placement (on the aural cartilage or mastoid) is beneficial to signal transmission.MethodsThis study included 35 patients (53 ears with an abnormal ear canal and severe conductive hearing loss) who were using CC hearing aids. Thresholds were compared between the transducers on the aural cartilage and on the mastoid.ResultsIn ears with bony aural atresia, thresholds were significantly improved when the transducer was placed on the aural cartilage compared to when it was placed on the mastoid for frequencies ≤ 500 Hz (P < .05). In aural atresia ears with a fibrotic tissue pathway, the aural cartilage stimulation improved the thresholds by approximately 20 dB for frequencies ≤ 1000 Hz (P < .05). In non‐atretic ears, the aural cartilage locations significantly worsened the threshold at 4000 Hz (P < .05).ConclusionOur findings demonstrated that placing the transducer at the aural cartilage improved the mid‐to‐low frequency thresholds compared to mastoid transduction in aural atretic ears. In contrast, no clear improvement to the signal transmission due to the transducer's placement on the aural cartilage was recognized in non‐atretic ears.Level of Evidence2
Encounters with the Flesh of Fish: Subsistence Fishing along the Anacostia River
Authors: Aboii Sheyda M. 
Published: November 2021

AbstractCoursing through Washington, DC, the Anacostia River is simultaneously an object of rehabilitation and a symbol of ongoing contamination. The river is a place where roadway runoff, sewer spillage, and trash add to the mix of industrial polychlorinated biphenyls and alkanes long wedded with the sediment. Yet, time spent with subsistence fishers along the Anacostia River also reveals how returning to the water’s edge, setting lines, hooking bait, or cleaning and consuming fish has the potential to expose the capitalist state. This essay considers the many facets of exposure beyond the sense of harm replete in environmentalist and environmental justice literatures. This essay ethnographically maps a constellation of bodies, environs, and exposures; it draws on Black feminist theory, including Leith Mullings’s conceptual treatment of environment, Audre Lorde’s erotics of the body, and Hortense J. Spillers’s analytic of the flesh, to conceptualize exposure as always an exposure to and an exposure of, or exposé. Through this synthesis, I not only trace the contours of a capitalist state where legacies of uneven contamination undergird selective prosperity but also attend to the excesses of exposure—what else there is to say about the river and ways of carefully paying attention along its banks.
The relationship between mindfulness and envy: The mediating role of emotional intelligence
Authors: Xiang Yanhui , Dong Xia , Zhao Jiaxu , Li Qingyin , Zhao Jingjing , Zhang Wenrui 
Published: November 2021

AbstractEnvy is a mixed negative emotion that is characterized by feelings of hostility, inferiority, resentment, and depression. It has been found that mindfulness is negatively associated with envy. This paper aimed to explore the interaction between mindfulness and envy by referring to the mindful emotion regulation model, and it also examines the mediation of emotional intelligence. Six hundred and seventy‐six participants (182 men and 494 women) completed the Mindful Attention Awareness Scale, the Dispositional Envy Scale, and the Wong Law Emotional Intelligence Scale. Results suggest that mindfulness is significantly and negatively correlated with envy. Meanwhile, a multiple mediation analysis indicated that regulation of emotion and use of emotion partially mediate the impact of mindfulness on envy. The current study not only provides a theoretical basis for possible mechanisms underlying the inhibition of envy, but also provides valuable guidance for developing mindfulness‐based intervention programs aiming at reducing the negative effects of envy.