bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interprofessional education-relevant accreditation standards in Canada: a comparative document analysis
Authors: Azzam Mohammad , Puvirajah Anton , Girard Marie-Andrée , Grymonpre Ruby E. 
Published: May 2021

Abstract
Background
Increasing evidence suggests that sustainable delivery of interprofessional education (IPE) has the potential to lead to interprofessional collaborative practice (IPCP), which in turn has the potential to lead to enhanced healthcare systems and improved patient-centered care health outcomes. To enhance IPE in Canada, the Accreditation of Interprofessional Health Education (AIPHE) project initiated collaborative efforts among accrediting organizations of six health professions to embed IPE language into their respective accreditation standards. To further understand the impact of the AIPHE project, this study evaluated the accountability of the IPE language currently embedded in Canadian health professions’ accreditation standards documents and examined whether such language spanned the five accreditation standards domains identified in the AIPHE project.

Methods
We conducted a comparative content analysis to identify and examine IPE language within the “accountable” statements in the current accreditation standards for 11 Canadian health professions that met our eligibility criteria.

Results and discussion
A total of 77 IPE-relevant accountable statements were identified across 13 accreditation standards documents for the 11 health professions. The chiropractic, pharmacy, and physiotherapy documents represented nearly 50% (38/77) of all accountable statements. The accountable statements for pharmacy, dentistry, dietetics, and nursing (registered) spanned across three-to-four accreditation standards domains. The remaining nine professions’ statements referred mostly to “Students” and “Educational program.” Furthermore, the majority of accreditation standards documents failed to provide a definition of IPE, and those that did, were inconsistent across health professions.

Conclusions
It was encouraging to see frequent reference to IPE within the accreditation standards of the health professions involved in this study. The qualitative findings, however, suggest that the emphasis of these accountable statements is mainly on the students and educational program, potentially compromising the sustainability and development, implementation, and evaluation of this frequently misunderstood pedagogical approach. The findings and exemplary IPE-relevant accountable statements identified in this paper should be of interest to all relevant stakeholders including those countries, where IPE accreditation is still emerging, as a means to accelerate and strengthen achieving desired educational and health outcomes.
Cost-effectiveness of a population-based AAA screening program for men over 65 years old in Iran
Authors: Daroudi Rajabali , Shafe Omid , Moosavi Jamal , Salimi Javad , Bayazidi Yahya , Zafarghandi Mohammad Reza , Maleki Majid , Moini Majid , Farshidmehr Pezhman , Sadeghipour Parham 
Published: May 2021

Abstract
Background
Screening program tend to recognized patients in their early stage and consequently improve health outcomes. Cost-effectiveness of the abdominal aortic aneurysm (AAA) screening program has been scarcely studied in developing countries. We sought to evaluate the cost-effectiveness of a screening program for the abdominal aortic aneurysm (AAA) in men aged over 65 years in Iran.

Methods
A Markov cohort model with 11 mutually exclusive health statuses was used to evaluate the cost-effectiveness of a population-based AAA screening program compared with a no-screening strategy. Transitions between the health statuses were simulated by using 3-month cycles. Data for disease transition probabilities and quality of life outcomes were obtained from published literature, and costs were calculated based on the price of medical services in Iran and the examination of the patients’ medical records. The outcomes were life-years gained, the quality-adjusted life-year (QALY), costs, and the incremental cost-effectiveness ratio (ICER). The analysis was conducted for a lifetime horizon from the payer’s perspective. Costs and effects were discounted at an annual rate of 3%. Uncertainty surrounding the model inputs was tested with deterministic and probabilistic sensitivity analyses.

Results
The mean incremental cost of the AAA screening strategy compared with the no-screening strategy was $140 and the mean incremental QALY gain was 0.025 QALY, resulting in an ICER of $5566 ($14,656 PPP) per QALY gained. At a willingness-to-pay of 1 gross domestic product (GDP) per capita ($5628) per QALY gained, the probability of the cost-effectiveness of AAA screening was about 50%. However, at a willingness-to-pay of twice the GDP per capita per QALY gained, there was about a 95% probability for the AAA screening program to be cost-effective in Iran.

Conclusions
The results of this study showed that at a willingness-to-pay of 1 GDP per capita per QALY gained, a 1-time AAA screening program for men aged over 65 years could not be cost-effective. Nevertheless, at a willingness-to-pay of twice the GDP per capita per QALY gained, the AAA screening program could be cost-effective in Iran. Further, AAA screening in high-risk groups could be cost-effective at a willingness-to-pay of 1 GDP per capita per QALY gained.
Effectiveness and cost-effectiveness of the PLAN-A intervention, a peer led physical activity program for adolescent girls: results of a cluster randomised controlled trial
Authors: Jago Russell , Tibbitts Byron , Willis Kathryn , Sanderson Emily , Kandiyali Rebecca , Reid Tom , Kipping Ruth R , Campbell Rona , MacNeill Stephanie J , Hollingworth William , Sebire Simon J. 
Published: May 2021

Abstract
Background
Physical activity is associated with improved health. Girls are less active than boys. Pilot work showed that a peer-led physical activity intervention called PLAN-A was a promising method of increasing physical activity in secondary school age girls. This study examined the effectiveness and cost-effectiveness of the PLAN-A intervention.

Methods
We conducted a cluster randomised controlled trial with Year 9 (13–14 year old) girls recruited from 20 secondary schools. Schools were randomly assigned to the PLAN-A intervention or a non-intervention control group after baseline data collection. Girls nominated students to be peer leaders. The top 18 % of girls nominated by their peers in intervention schools received three days of training designed to prepare them to support physical activity. Data were collected at two time points, baseline (T0) and 5–6 months post-intervention (T1). Participants wore an accelerometer for seven days to assess the primary outcome of mean weekday minutes of moderate-to-vigorous physical activity (MVPA). Multivariable mixed effects linear regression was used to estimate differences in the primary outcome between the two arms on an Intention-to-Treat (ITT) basis. Resource use and quality of life were measured and a within trial economic evaluation from a public sector perspective was conducted.

Results
A total of 1558 girls were recruited to the study. At T0, girls in both arms engaged in an average of 51 min of MVPA per weekday. The adjusted mean difference in weekday MVPA at T1 was − 2.84 min per day (95 % CI = -5.94 to 0.25) indicating a slightly larger decline in weekday MVPA in the intervention group. Results were broadly consistent when repeated using a multiple imputation approach and for pre-specified secondary outcomes and sub-groups. The mean cost of the PLAN-A intervention was £2817 per school, equivalent to £31 per girl. Economic analyses indicated that PLAN-A did not lead to demonstrable cost-effectiveness in terms of cost per unit change in QALY.

Conclusions
This study has shown that the PLAN-A intervention did not result in higher levels of weekday MVPA or associated secondary outcomes among Year 9 girls. The PLAN-A intervention should not be disseminated as a public health strategy.

Trial registration
ISRCTN14539759–31 May, 2018.
Lumbar and ventricular CSF concentrations of extracellular matrix proteins before and after shunt surgery in idiopathic normal pressure hydrocephalus
Authors: Minta Karolina , Jeppsson Anna , Brinkmalm Gunnar , Portelius Erik , Zetterberg Henrik , Blennow Kaj , Tullberg Mats , Andreasson Ulf 
Published: May 2021

Abstract
Background
Idiopathic normal pressure hydrocephalus (iNPH) is a reversible CNS disease characterized by disturbed cerebrospinal fluid (CSF) dynamics. Changes in the extracellular matrix (ECM) composition might be involved in the pathophysiology of iNPH. The aim of this study was to explore possible differences between lumbar and ventricular CSF concentrations of the ECM markers brevican and neurocan, matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and their relation to clinical symptoms in iNPH patients before and after shunt surgery.

Methods
Paired lumbar and ventricular CSF was collected from 31 iNPH patients, before and four months after shunt surgery. CSF was analysed for concentrations of tryptic peptides originating from brevican and neurocan using a mass spectrometry-based panel, and for MMP-1, -2, -9, -10 and TIMP-1 using fluorescent or electrochemiluminescent immunoassays.

Results
Brevican and neurocan peptide levels were not influenced by CSF origin, but MMP-1, -2, -10 and TIMP-1 were increased (p ≤ 0.0005), and MMP-9 decreased (p ≤ 0.0003) in lumbar CSF compared with ventricular CSF. There was a general trend of ECM proteins to increase following shunt surgery. Ventricular TIMP-1 was inversely correlated with overall symptoms (rho = − 0.62, p < 0.0001). CSF concentrations of the majority of brevican and neurocan peptides were increased in iNPH patients with a history of cardiovascular disease (p ≤ 0.001, AUC = 0.84–0.94) compared with those without.

Conclusion
Levels of the CNS-specific proteins brevican and neurocan did not differ between the lumbar and ventricular CSF, whereas the increase of several CNS-unspecific MMPs and TIMP-1 in lumbar CSF suggests contribution from peripheral tissues. The increase of ECM proteins in CSF following shunt surgery could indicate disturbed ECM dynamics in iNPH that are restored by restitution of CSF dynamics.
Patients with first versus multiple episodes of self-harm: how do their profiles differ?
Authors: Golay Philippe , Ostertag Louise , Costanza Alessandra , Van der Vaeren Bénédicte , Dorogi Yves , Saillant Stéphane , Michaud Laurent 
Published: May 2021

AbstractBackgroundSelf-harm (SH) is among the strongest predictors of further episodes of SH, suicide attempt, and death by suicide. People who repeteadly harm themselves are at even higher risk for suicide. Factors influencing the repetition are important to identify when assessing suicidal risk and thereafter to offer specific interventions. Therefore, this study aimed to compare first versus multiple episodes characteristics in a large sample of patients in french-speaking Switzerland.MethodWe used the database from the French-speaking Swiss program for monitoring SH. Data of the psychiatric assessment of all adults admitted for SH were collected in the emergency department of four Swiss city hospitals between December 2016 and October 2019.Results1730 episodes of SH were included. Several variables were significantly associated with multiple episodes, including diagnosis (over representation of personality disorders and under representation of anxiety disorders), professional activity (Invalidity insurance more frequent) and prior psychiatry care.ConclusionsPatients suffering from a personality disorder and those with invalidity insurance are at risk for multiple episodes of SH and should be targeted with specific interventions.
Sonication in the diagnosis of fracture-related infections (FRI)—a retrospective study on 230 retrieved implants
Authors: Bellova Petri , Knop-Hammad Veronika , Königshausen Matthias , Schildhauer Thomas A. , Gessmann Jan , Baecker Hinnerk 
Published: May 2021

Abstract
Background
In fracture-related infections (FRI), both the diagnosis of the infection and the identification of the causative pathogen are crucial to optimize treatment outcomes. Sonication has been successfully used for periprosthetic joint infections (PJI); however, its role in FRI remains unknown. Our aim was to determine the diagnostic accuracy (sensitivity, specificity) of sonicate fluid culture (SFC). The primary objective was to compare SFC with peri-implant tissue culture (PTC) overall and among subgroups using the consensus definition by Metsemakers et al. The secondary objective was to determine the yield of SFC in possible fracture-related infections (PFRI).

Methods
From March 2017 to May 2019, 230 cases of retrieved implants were retrospectively reviewed. To perform sonication, explants were placed in sterile polypropylene jars intraoperatively. After treatment in an ultrasonic bath (Bandelin, Berlin, Germany), sonicate fluid was incubated into blood culture bottles, and conventional culturing was eventually performed. Sensitivity and specificity were determined using two-by-two contingency tables. McNemar’s test was used to compare proportions among paired samples while Fisher’s exact test was used for comparison between categorical variables.

Results
Of the 230 cases, 107 were identified as FRI, whereas 123 were aseptic revision cases (ARC). Of the latter, 105 were labeled as PFRI. Sensitivity of SFC was higher in comparison with PTC, although this did not reach statistical significance (90.7% vs. 84.1%; p = .065). The specificity of SFC was significantly lower than that of PTC (73.2% vs. 88.6%; p = .003). In PFRI, SFC yielded significantly more positive results than PTC (33/105 vs. 14/105; p = .003). Overall, 142 pathogens were identified by SFC, whereas 131 pathogens were found by PTC.

Conclusions
We found that sonication of fracture fixation devices may be a useful adjunct in FRI, especially in “low-grade” infections lacking confirmatory clinical criteria. Standardized diagnostic protocols are warranted in order to further optimize the diagnostic accuracy.
Malaria and Cancer: a critical review on the established associations and new perspectives
Authors: Ellis Toby , Eze Elvis , Raimi-Abraham Bahijja Tolulope 
Published: May 2021

Abstract
Objectives
Cancer and malaria both have high incidence rates and are leading causes of mortality worldwide, especially in low and middle-income countries with reduced access to the quality healthcare. The objective of this critical review was to summarize key associations and new perspectives between the two diseases as is reported in existing literature.

Methods
A critical review of research articles published between 1st January 2000 – 1st July 2020 which yielded 1753 articles. These articles were screened based on a precise inclusion criteria. Eighty-nine eligible articles were identified and further evaluated.

Results
Many articles reported anti-cancer activities of anti-malarial medicines, including Artemisinin and its derivatives. Other articles investigated the use of chemotherapy in areas burdened by malaria, treatment complications that malaria may cause for cancer patients as well as ways to circumvent cancer related drug resistance. Potential novel targets for cancer treatment, were identified namely oncofoetal chondroitin sulphate and haem, as well as the use of circumsporozoite proteins. A number of articles also discussed Burkitt lymphoma or febrile neutropenia.

Conclusions
Overall, excluding for Burkitt lymphoma, the relationship between cancer and malaria requires further extensive research in order to define association. There great potential promising new novel anti-cancer therapies using anti-malarial drugs.

Graphical abstract
Created using BioRender
Tick infestation on medium–large-sized mammalian hosts: are all equally suitable to Ixodes ricinus adults?
Authors: Mysterud Atle , Hügli Christian , Viljugrein Hildegunn 
Published: May 2021

Abstract
Background
In Europe, the generalist tick, Ixodes ricinus, is the main vector of several tick-borne pathogens causing diseases in humans and livestock. Understanding how different species of hosts limit the tick population is crucial for management. In general, larger ectoparasites are expected to select hosts with larger body size. Consistent with this, larval and nymphal I. ricinus can feed on a wide range of different-sized vertebrates, while the adult female stage is expected to rely on a medium–large-sized host for reproduction. However, we still have a limited understanding of whether medium-sized hosts other than roe deer can serve as hosts to adult ticks, and other factors than size may also affect host selection.

Methods
To increase our understanding of the suitability of the different species of medium-sized hosts for adult ticks, we sampled mainly roadkill mammals from within the questing season of ticks. We counted life stages of ticks on roe deer (Capreolus capreolus) (n = 29), red fox (Vulpes vulpes) (n = 6), badger (Meles meles) (n = 14) and red squirrel (Sciurus vulgaris) (n = 17) from spatially overlapping populations in Norway, and analysed variation between species across different body parts with a mixed-effects negative binomial model (with and without zero-inflation).

Results
Red squirrel hosted a high density of larval and nymphal I. ricinus, but only one individual had adult female ticks. Roe deer hosted by far the largest number of adult ticks. Badgers had very few ticks, possibly due to their thick skin. Red foxes had intermediate numbers, but a high proportion of subcutaneous, dead ticks (69.3%), suggesting they are not very suitable hosts. Body mass predicted the presence of adult I. ricinus ticks. However, species was a better predictor than body mass for number of ticks, suggesting there was species variation in host suitability beyond body mass per se.

Conclusions
Our study provides evidence that roe deer are indeed the main suitable reproduction host to adult I. ricinus ticks, and are likely a key to host limitation of the tick population in this northern ecosystem.

Graphical Abstract
The effects of repetition frequency on the illusory truth effect
Authors: Hassan Aumyo , Barber Sarah J. 
Published: May 2021

AbstractRepeated information is often perceived as more truthful than new information. This finding is known as the illusory truth effect, and it is typically thought to occur because repetition increases processing fluency. Because fluency and truth are frequently correlated in the real world, people learn to use processing fluency as a marker for truthfulness. Although the illusory truth effect is a robust phenomenon, almost all studies examining it have used three or fewer repetitions. To address this limitation, we conducted two experiments using a larger number of repetitions. In Experiment 1, we showed participants trivia statements up to 9 times and in Experiment 2 statements were shown up to 27 times. Later, participants rated the truthfulness of the previously seen statements and of new statements. In both experiments, we found that perceived truthfulness increased as the number of repetitions increased. However, these truth rating increases were logarithmic in shape. The largest increase in perceived truth came from encountering a statement for the second time, and beyond this were incrementally smaller increases in perceived truth for each additional repetition. These findings add to our theoretical understanding of the illusory truth effect and have applications for advertising, politics, and the propagation of “fake news.”
Long-ranged velocity correlations in dense systems of self-propelled particles
Authors: Szamel Grzegorz , Flenner Elijah 
Published: May 2021

Abstract
Model systems of self-propelled particles reproduce many phenomena observed in laboratory active matter systems that defy our thermal equilibrium-based intuition. In particular, in stationary states of self-propelled systems, it is recognized that velocities of different particles exhibit non-trivial equal-time correlations. Such correlations are absent in equivalent equilibrium systems. Recently, researchers found that the range of the velocity correlations increases with increasing persistence time of the self-propulsion and can extend over many particle diameters. Here we review the initial studies of long-ranged velocity correlations in solid-like systems of self-propelled particles. Then, we demonstrate that the long-ranged velocity correlations are also present in dense fluid-like systems. We show that the range of velocity correlations in dense systems of self-propelled particles is determined by the combination of the self-propulsion and the virial bulk modulus that originates from repulsive interparticle interactions.
How we are leading a 3-XORSAT challenge: From the energy landscape to the algorithm and its efficient implementation on GPUs
(a)
Authors: Bernaschi M. , Bisson M. , Fatica M. , Marinari E. , Martin-Mayor V. , Parisi G. , Ricci-Tersenghi F. 
Published: May 2021

Abstract
A recent 3-XORSAT challenge required to minimize a very complex and rough energy function, typical of glassy models with a random first-order transition and a golf-course–like energy landscape. We present the ideas beyond the quasi-greedy algorithm and its very efficient implementation on GPUs that are allowing us to rank first in such a competition. We suggest a better protocol to compare algorithmic performances and we also provide analytical predictions about the exponential growth of the times to find the solution in terms of free-energy barriers.
Decoupling redshift: The key to conciliate global and local estimates of the Universe expansion rate
Authors: Barboza Edésio M. , Abreu Everton M. C. , Ananias Neto Jorge 
Published: May 2021

Abstract
To explain the

discrepancy between the local

and the global

estimates of the Universe expansion rate, H
0, becomes one of the most challenging problems in contemporary cosmology. Underestimated systematic errors as well as new physics beyond the standard ΛCDM model, has been invoked to solve, or at least alleviate, this problem. In this paper we show that we can conciliate the local measurement of the Hubble constant with its global estimate in a very simple way without making any of these assumptions. This is achieved if we deal with the decoupling redshift,

, as a free parameter. By noting that the dependence of the cosmic microwave background (CMB) observables on H
0 comes from the decoupling redshift

we show that, by incorporating a missing parameter, the electron fraction

, to the

functional form, local and global estimates of H
0 agree with each other perfectly. The effect of introducing

is the same that treat

as free parameter which should be fitted along with the model parameters. The CMB data and the local estimates of H
0 are reconciled if

, a value

higher than the value obtained from the usual calculations.