bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feebly-interacting particles: FIPs 2020 workshop report
Authors: Agrawal P. , Bauer M. , Beacham J. , Berlin A. , Boyarsky A. , Cebrian S. , Cid-Vidal X. , d’Enterria D. , De Roeck A. , Drewes M. , Echenard B. , Giannotti M. , Giudice G. F. , Gninenko S. , Gori S. , Goudzovski E. , Heeck J. , Hernandez P. , Hostert M. , Irastorza I. G. , Izmaylov A. , Jaeckel J. , Kahlhoefer F. , Knapen S. , Krnjaic G. , Lanfranchi G. , Monroe J. , Outschoorn V. I. Martinez , Lopez-Pavon J. , Pascoli S. , Pospelov M. , Redigolo D. , Ringwald A. , Ruchayskiy O. , Ruderman J. , Russell H. , Salfeld-Nebgen J. , Schuster P. , Shaposhnikov M. , Shchutska L. , Shelton J. , Soreq Y. , Stadnik Y. , Swallow J. , Tobioka K. , Tsai Y.-D. 
Published: November 2021

AbstractWith the establishment and maturation of the experimental programs searching for new physics with sizeable couplings at the LHC, there is an increasing interest in the broader particle and astrophysics community for exploring the physics of light and feebly-interacting particles as a paradigm complementary to a New Physics sector at the TeV scale and beyond. FIPs 2020 has been the first workshop fully dedicated to the physics of feebly-interacting particles and was held virtually from 31 August to 4 September 2020. The workshop has gathered together experts from collider, beam dump, fixed target experiments, as well as from astrophysics, axions/ALPs searches, current/future neutrino experiments, and dark matter direct detection communities to discuss progress in experimental searches and underlying theory models for FIPs physics, and to enhance the cross-fertilisation across different fields. FIPs 2020 has been complemented by the topical workshop “Physics Beyond Colliders meets theory”, held at CERN from 7 June to 9 June 2020. This document presents the summary of the talks presented at the workshops and the outcome of the subsequent discussions held immediately after. It aims to provide a clear picture of this blooming field and proposes a few recommendations for the next round of experimental results.
Space use and parental care behaviour in Andinobates claudiae (Dendrobatidae)
Authors: Cossio Ricardo , Wright Jennifer , Acosta Rebeca , Rodríguez Ariel 
Published: November 2021

Abstract
The selection of habitats with potential reproductive resources may maximize individual reproductive success and overall fitness. Dendrobatid frogs display remarkable parental care which is associated with water bodies (phytotelmata) contained in plants with characteristics that are important to offspring survival. It has been shown that the size of phytotelmata is a key factor that drove the divergence in parental care patterns in poison frogs and that the distribution of reproductive resources can influence space use in these species. Here, we investigated parental care strategies and the influence of reproductive resource distribution on space use patterns in a wild population of Andinobates claudiae in Bocas del Toro, Panama. We identified the phytotelmata characteristics that predict tadpole deposition and analysed the association between the spatial distribution of phytotelmata and spatial use of males and females. Our observations showed that this species mates polygamously and exhibits male parental care. We found that male frogs have smaller kernel density home ranges and core areas compared to females, and that space use is related to the density of Heliconia plants whose axil cavities are used for tadpole rearing. Furthermore, we found that tadpoles were more frequently found in phytotelmata that were at lower heights and contained larger water volumes. Fathers invested time inspecting multiple cavities and travelled further than predicted from their territories to find suitable deposition sites. Our observations suggest a selective choice of phytotelmata regarding tadpole deposition, where distribution and quality of cavities might influence parental care decisions.
Parliamentary Diplomacy: A Review Article
Authors: Stavridis Stelios 
Published: November 2021

Abstract
There is growing academic interest in parliamentary diplomacy. This is a welcome development because for many years only parliamentary practitioners themselves paid much attention to the parliamentarization of international affairs, and then mainly from a technical interparliamentary cooperation perspective. This presently consolidating academic literature still requires a fresh impetus if only because there still remain numerous important and problematic issues that need to be addressed. This article will first set the study of parliamentary diplomacy in its wider context, offering examples and definitions. It will then review its main findings to date – before suggesting a number of important research questions that deserve further attention. It is argued that future studies will need to examine them in more detail in order to strengthen academic research into this ever-expanding worldwide phenomenon. The conclusions will also include a practical suggestion for developing this important new dimension in diplomatic studies even further.
Evaluating the Cost for Robotic vs “Non-Robotic” Transhiatal Esophagectomy
Authors: Ross Sharona B. , Rayman Shlomi , Thomas Ja’Karri , Peek George , Crespo Kaitlyn , Syblis Cameron , Sucandy Iswanto , Rosemurgy Alexander 
Published: November 2021

Introduction This study was undertaken to analyze and compare the cost of robotic transhiatal esophagectomy (THE) to “non-robotic” THE (ie, “open” and laparoscopic). Methods With IRB approval, we prospectively followed 82 patients who underwent THE. We analyzed clinical outcomes and perioperative charges and costs associated with THE. To compare profitability, the robotic approach was analyzed against “non-robotic” approaches of THE using F-test, Mann-Whitney U test/Student’s t-test, and Fisher’s exact test. Statistical significance was reported as P ≤0.05. Data are presented as median (mean ± SD). Results 67 patients underwent the robotic approach, and 15 patients underwent “non-robotic” approach; 4 were “open” and 11 were laparoscopic. 79 patients had adenocarcinoma. Operative duration for robotic THE was 327 (331 ± 82.8) vs 213 (225 ± 62.0) minutes ( P = 0.0001) and estimated blood loss was 150 (184 ± 136.1) vs 300 (476 ± 708.7) mL ( P = 0.0001). Length of stay was 7 (11 ± 11.8) vs 8 (12 ± 10.6) days ( P = 0.76). 16 patients had post-operative complications with a Clavien-Dindo score of three or more. Hospital charges for robotic THE were $197,405 ($259,936 ± 203,630.8) vs “non-robotic” THE $159,588 ($201,565 ± $185,763.5) ( P = 0.31). Cost of care for robotic THE was $34,822 ($48,844 ± $45,832.8) vs “non-robotic” THE was $23,939 ($39,386 ± $44,827.2) ( P = 0.47). Payment received for robotic THE was $14,365 ($30,003 ± $40,874.7) vs “non-robotic” THE was $28,080 ($41,087 ± $44,509.1) ( P = 0.41). 15% of robotic operations were profitable vs 13% of “non-robotic” operations. Conclusions Patients were predominantly older overweight men who had adenocarcinoma of the esophagus. The robotic approach had increased operative time and minimal blood loss. More than a fourth of operations included concomitant procedures. Patients were discharged approximately one week after THE. Overall, the robotic approach has no apparent significant differences in charges, cost, or profitability.
Time is of the Essence: Impact of a More Aggressive Chemical Venous Thromboembolism Prophylaxis Regimen on Trauma Patients
Authors: Schroeppel Thomas J. , Clement Lesley P. , Douville Alyssa A. , Schmoekel Nathan H. , Stassinopoulos Jerry , Decker Cassandra , Stillman Zachery E. , Rodriquez Jennifer , Brockman Valerie P. , Hennessy Elizabeth , Heise Holly , Khan Abid D. 
Published: November 2021

Background Trauma patients are at high risk for venous thromboembolism (VTE). Opportunity for chemical VTE prophylaxis improvement was identified and practice was altered to start chemoprophylaxis on admission in most patients. The purpose of this study was to determine if early VTE prophylaxis is safe and reduces VTE. Methods The trauma registry was queried over a 12-month period for patients admitted greater than 1 day for traumatic injury. The study spanned 6 months on either side of instituting aggressive chemoprophylaxis. Patients were risk adjusted on demographics, Injury Severity Score, transfusions, procedure type, length of stay, and mortality. Pre-intervention patients were then compared to patients in the aggressive cohort with the primary outcome of VTE. Secondary outcomes included transfusions, mortality, and length of stay (LOS). Results 1597 patients were identified over the study period with 754 (47%) patients in the aggressive period. There were no differences in age, sex, Injury Severity Score, transfusions, procedures, or LOS between cohorts. Pre-algorithm patients were more likely to have penetrating mechanism (9.3% vs 6.6%; P = .009) and longer time to VTE prophylaxis (23.3 vs 13.9 hours; P < .001). No differences were noted in anticoagulant, VTE rate (2.0% vs 1.2%; P = .195), or mortality. Linear regression analysis identified time to chemical prophylaxis as significant predictor of VTE (β = 43.9, P < .001). Conclusions Early aggressive chemical VTE prophylaxis is safe without increasing transfusions. Venous thromboembolism rates were decreased, but did not reach statistical significance.
Hiatal Hernia After Esophagectomy: A Single-Center Retrospective Analysis of a Rare Postoperative Phenomenon
Authors: Benzie Annie Laurie , Darwish Muhammad B. , Basta Anthony , McLaren Patrick J. , Cho Edward E. , Osman Houssam , Jay John , Jeyarajah D. Rohan 
Published: November 2021

Development of a post-esophagectomy hiatal hernia (PEHH) is a rare, but problematic, sequela with the current reported prevalence ranging up to 20%. To determine the incidence rate of PEHH at our institution, a retrospective review of all transhiatal esophagectomies performed from 2012 to 2020 was conducted. Demographic, operative, and oncologic data were collected, rates of PEHH were calculated, and characteristics of subsequent repair were reviewed and analyzed. A total of 160 transhiatal esophagectomies were included, of which four patients (2.5%) developed a PEHH at a mean of 12 months postoperatively (range: 3-28 months) with symptomatology driving the diagnosis for three patients. The limited size of our study does not allow for statistically significant determinations regarding risk factors or method of repair. The true prevalence of a hiatal defect is likely higher than reported, as clinically asymptomatic patients are not captured in our current literature.
Does Time to Pelvic Fixation Influence Outcomes in Trauma Patients?
Authors: Taylor Nicholas A. , Smith Alison A. , Marr Alan , Stuke Lance , Greiffenstein Patrick , Schoen Jonathan , Brown Tommy , Chapman Brett , Hunt John P. 
Published: November 2021

Background Pelvic fractures cause significant morbidity in the trauma population. Many factors influence time to fracture fixation. No previous study has determined the optimal time window for pelvic fixation. Methods A retrospective review of trauma patients with pelvic fractures from 2016 to 2020 was performed. Patients were stratified into EARLY and LATE groups, by time to fixation within 3 days or greater than 3 days whether from admission or from completion of a life-saving procedure. Unpaired Student’s t-test and Fisher’s exact test were performed with multiple linear regression for variables with P < .2 on univariate analysis. Results 287 patients were identified with a median fixation time of 3 days. There was no significant difference in demographics, incidence of preceding life-saving procedure, angioembolization, or mechanism of injury in the 2 groups ( P > .05). Length of stay in the EARLY group was significantly reduced at 11.9 +/− .7 days compared to 18.0 +/−1.2 days in the LATE group ( P < .001). There was no significant difference in rates of ventilator-associated pneumonia, deep vein thrombosis, pulmonary embolism (PE), acute kidney injury (AKI), pressure ulcer, or acute respiratory distress syndrome (ARDS) ( P > .05). There were significantly more SSIs (surgical site infections) in the LATE group. After multiple linear regression adjusting for covariates of age and ISS, the difference in hospital LOS was 5.5 days (95% CI −8.0 to −3.1, P < .001). Discussion Fixation of traumatic pelvic fractures within 3 days reduced LOS. Prospective multi-center studies will help identify additional factors to decrease time to surgery and improve patient outcomes.
An Assessment of Timeliness and Quality of Communicable Disease Surveillance System in the Kurdistan Region of Iraq
Authors: Hamalaw Soran Amin , Bayati Ali Hattem , Babakir-Mina Muhammed 
Published: November 2021

Background The quality of the surveillance system can be defined by attributes such as completeness, timeliness, usefulness, simplicity, flexibility, acceptability, and reliability. This study aims to assess these quality features of the communicable disease surveillance system (CDSS) in the Kurdistan Region of Iraq. Methods This study was conducted using a retrospective review of records and documents, and the interviews with the surveillance staff (n = 82) of the Kurdistan governorates during 2018, 2019, and 2020. The World Health Organization (WHO) guideline 2006 indicators were used for evaluation and monitoring the quality of the communicable disease surveillance system. The data analyzed and showed as frequencies and percentages using Statistical Package for the Social Sciences (SPSS) version 26 software. Results The reporting timeliness declined from 98% in 2019 to 69% in 2020. At the same time, there was an improvement in completeness of reporting from 83% in 2018 to 99% in 2020. The total scores of other surveillance quality attributes, simplicity, usefulness, flexibility, acceptability, and reliability, were 75%, 72%, 67%, 72%, and 69%, respectively. Conclusion Current findings demonstrate that the CDSS is still facing significant challenges in timeliness simplicity, usefulness, flexibility, acceptability, and reliability. Further studies to assess the system’s quality, particularly the system’s timeliness of outbreak response, sensitivity, and specificity, are recommended.
Coagulation profile and correlation between D-dimer, inflammatory markers, and COVID-19 severity in an Indonesian national referral hospital
Authors: Sukrisman Lugyanti , Sinto Robert 
Published: November 2021

Background Coagulopathy and inflammation are associated with coronavirus disease 2019 (COVID-19) severity. This study assessed D-dimer concentration and its correlation with inflammatory markers and COVID-19 severity. Methods This was a retrospective cross-sectional study involving 194 COVID-19 cases, with the severity of infection graded in accordance with the World Health Organization (WHO) guidelines. We measured D-dimer, C-reactive protein (CRP), and ferritin on admission and determined the cutoff values for D-dimer and CRP and evaluated the correlation between D-dimer and CRP and ferritin. Results Median D-dimer, CRP, and ferritin concentrations were 2240 µg/L, 73.2 mg/L, and 1173.8 µg/mL, respectively. The highest median D-dimer value was seen in mild and moderate acute respiratory distress syndrome (ARDS). The highest ferritin concentration was seen in severe ARDS. There was a significant correlation between D-dimer value and CRP (r = 0.327), but no significant correlation between D-dimer and ferritin (r = 0.101). The area under the receiver operating characteristic curve (AUC) for the combination of CRP ≥72.65 mg/L and D-dimer ≥1250 µg/L as a marker of COVID-19 severity was 0.722 (95% confidence interval (CI): 0.615–0.781). Conclusion The combination of CRP ≥72.65 mg/L and D-dimer ≥1250 µg/L can be used as marker of COVID-19 severity, with moderate accuracy.
Survivorship Rate and Clinical Outcomes 10 Years After Arthroscopic Correction of Symptomatic Femoroacetabular Impingement
Authors: Carton Patrick , Filan David , Mullins Karen 
Published: November 2021

Background: Femoroacetabular impingement (FAI) is a common mechanical hip condition, prevalent in both the athletic and the general population. Surgical intervention is an effective treatment option that improves both symptoms and function in short- to medium-term follow-up. Few studies within the literature have reported the longer-term success of arthroscopic surgery. Purpose: The aim of this study was to quantify the 10-year survivorship and clinical outcome for patients treated arthroscopically for symptomatic FAI. Study Design: Case series; Level of evidence, 4. Methods: Patients from our hip registry (n = 119) completed patient-reported outcome measures (PROMs) including the modified Harris Hip Score (mHHS), University of California Los Angeles (UCLA) activity scale, 36-Item Short Form Health Survey (SF-36), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at a minimum of 10 years after arthroscopy (range, 10-12 years). Results were compared with baseline scores using the Wilcoxon signed rank test. The associations among several prognostic factors, which included age, sex, Tönnis grade, and labral treatment, and subsequent conversion to total hip replacement (THR) or repeat hip arthroscopy (RHA) were analyzed using the chi-square analysis. Relationships between range of motion and radiological findings with clinical outcome were also examined using Pearson correlation analysis. Minimal clinically important difference (MCID) was calculated using a distribution method (0.5 standard deviation of the change score), and substantial clinical benefit (SCB) was determined using an anchor method. Finally, receiver operating characteristic curves with subsequent Youden index were used to determine cutoffs for PROMs, which equated to a Patient Acceptable Symptom State (PASS). Results: A total of 8.4% of cases required conversion to THR, and 5.9% required RHA. Statistically significant improvements in mHHS, SF-36, and WOMAC scores, with high satisfaction (90%), were observed 10 years after surgery. No significant change was seen in activity level (UCLA score) despite patients being 10 years older. A high percentage of patients achieved MCID for mHHS (88%), SF-36 (84%), and WOMAC (60%). The majority of patients also achieved PASS (62% for mHHS, 85% for UCLA, 78% for SF-36, and 84% for WOMAC) and SCB (74% for mHHS, 58% for UCLA, 52% for SF-36, and 56% for WOMAC). Conclusion: Arthroscopic intervention is a safe and viable treatment option for patients with symptomatic FAI, and patients can expect long-term improvements and high satisfaction. Results indicated a high satisfaction (90%) and survivorship rate (91.6%), with excellent clinical outcome, 10 years after the initial procedure.
DAPK1 may be a potential biomarker for arterial aneurysm in clinical treatment and activated inflammation levels in arterial aneurysm through NLRP3 inflammasome by Beclin1
Authors: Wu Senyan , Lu Wei , Cheng Guobing , Wu Jiawen , Liao Sheng , Hu Qiang , Li Xiaoyang , Jiang Buping 
Published: November 2021

Background Death-associated protein kinase (DAPK1) is one of the positive regulators of apoptosis, and it is widely involved in apoptosis induced by multiple pathways. We examined that the function of DAPK1 in Clinical treatment of arterial aneurysm and its underlying mechanisms. Arterial aneurysm is a common cerebrovascular disease with high disability and fatality rate. Objectives Male C57BL/6 mice or DAPK1−/− mice were injected with 50 mg/kg pentobarbital sodium and then were injected with angiotensin II (AngII) infusion for vivo model. hASMCs (Human artery smooth muscle cell) were treated with murine recombinant IL-6 (20  ng ml−1; Cell Signaling) for vitro model. Results DAPK1 gene, mRNA expression, and protein expression were induced in mice of arterial aneurysm. DAPK1 mRNA expression was increased and Area Under Curve was 0.9075 in patients with arterial aneurysm. Knockout of DAPK1 decreased inflammation and vascular injury in mice model of arterial aneurysm. Beclin1/NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) signal pathway is a critical downstream effector of DAPK1 by TAP production. The regulation of Beclin1 participated in the effects of DAPK1 on inflammation of arterial aneurysm by ATP-dependent NLRP3 inflammasome. The regulation of NLRP3 participated in the effects of DAPK1 on inflammation of arterial aneurysm. Conclusion Collectively, our data indicated that DAPK1 may be a potential biomarker for arterial aneurysm in clinical treatment and activated inflammation levels in arterial aneurysm through NLRP3 inflammasome by Beclin1. DAPK1 might be a key pathogenic event underlying excess inflammation of arterial aneurysm.
Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats
Authors: Nagarajan Manigandan , Raja Boobalan , Manivannan Jeganathan 
Published: November 2021

Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore the adverse effects of daily tolerable and “safe” dose of bisphenol A (BPA) under hypertensive conditions. The current study exposed the Nω-nitro-l-arginine methyl ester (L-NAME, 40 mg/kg b.w/day) induced hypertensive Wistar rats to BPA (50 μg/kg b.w/day) by oral administration along with appropriate controls for 30 days period. The results illustrate that a ‘safe’ dose of BPA does not influence the systolic blood pressure (SBP) and levels of circulatory biomarkers of tissue damage. On the other hand, BPA exposure significantly ( p < 0.05) elevates the thiobarbituric acid reactive substances (TBARS) content in plasma and tissues (heart, aorta, liver and kidney) in hypertensive rats when compared with respective control (BPA alone exposed) rats. Similarly, a significant modulation of ROS generation in RBC, plasma nitric oxide (NO) level and angiotensin-converting enzyme (ACE) activity was observed only under hypertensive milieu. In conclusion, the observed adverse effects during ‘safe’ dose of BPA exposure are specific to the hypertensive condition. Therefore, a precise investigation to explore the effects of BPA exposure in vulnerable hypertensive populations is highly suggested.