bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eficacia y seguridad del acceso radial y femoral en pacientes con síndrome coronario agudo llevados a intervencionismo coronario
Authors: Tamayo Artunduaga Natalia , Vallejo Garcia Franco Javier , Senior Juan Manuel , Fernandez Cadavid Andres , Rodriguez Dimuro Arturo , Toro Escobar Juan Manuel 
Published: November 2021

Introducción: el acceso transradial ha surgido como una alternativa atractiva a la vía femoral para realizar coronariografías e intervenciones coronarias. Describimos nuestra experiencia, y comparamos el acceso radial con una cohorte de acceso femoral en un periodo de tiempo.
Objetivo: identificar las complicaciones vasculares relacionadas con la coronariografía en pacientes de la unidad de dolor torácico de una institución de alta complejidad de la ciudad de Medellín. Materiales y métodos: estudio epidemiológico observacional, analítico, de una cohorte retrospectiva de pacientes mayores de 18 años que ingresaron a la unidad de dolor torácico del hospital Universitario San Vicente Fundación con diagnóstico de síndrome coronario agudo con y sin elevación del ST, y a los cuales se les realizó coronariografía por acceso radial y femoral.
Resultados: se evaluaron 675 pacientes, de los cuales 59.6% (n=402) se les realizó acceso femoral y 40.4% (n=273) acceso radial con diferencias, en relación al sexo y aspectos personales como el tabaquismo y la enfermedad renal crónica. Respecto a las complicaciones según el tipo de acceso, se hallaron diferencias significativas en la presencia de hematoma femoral (OR= 5.6; IC 95%: 1.28; 24.63) y el espasmo radial (p<0.05).
Conclusión: los accesos radial y femoral son seguros y efectivos, sin embargo la disminución significativa de las complicaciones vasculares puede ser una razón para preferir el acceso radial como técnica de elección en la mayoría de estos pacientes
Tromboprofilaxis en el paciente médico hospitalizado por medicina interna: Un estudio de corte transversal
Authors: Diaztagle Fernandez Juan José , Cely Javier Enrique , Sánchez Cantillo Jorge de Jesús , Sánchez Esquivel Fernando Antonio , Mendoza Olmos Elkin José 
Published: November 2021

Introducción:
El tromboembolismo venoso es una de las principales causas de morbimortalidad prevenible seguida de una hospitalización. Las Heparinas han demostrado ser eficaces para su prevención, sin embargo se ha documentado la subutilización de estos fármacos, por lo que implementar medidas que garanticen la formulación adecuada es fundamental. En nuestra institución se han instaurado estrategias para mejorar la formulación de estos fármacos con resultados iniciales favorables, pero se desconoce el efecto a más largo plazo.
Métodos:
Estudio descriptivo, retrospectivo de corte transversal. Se evaluaron pacientes mayores de 18 años, hospitalizados por Medicina Interna entre junio y noviembre de 2012. Se estimó una muestra representativa de 102 pacientes. Se identificó la formulación de la tromboprofilaxis al segundo día de hospitalización, se determinó si fue adecuada según las guías institucionales y los errores en la prescripción de la misma. Se comparó los resultados con dos mediciones previas realizadas en la institución.
Resultados:
De los 102 pacientes evaluados, la tromboprofilaxis fue adecuada en 63 (61,8%) e inadecuada en 39 (38,2%). Las causas más frecuentes de error fueron: formulación en pacientes de bajo riesgo 18 (46,1%) y error por omisión en 12 (30,7%) pacientes. La formulación en pacientes con indicación y sin contraindicación disminuyó de 92% a 82% y en pacientes sin indicación aumentó de 50% a 56,2%, con relación a una medida previa realizada después de la difusión de guías institucionales.
Conclusiones:
La tromboprofilaxis en pacientes hospitalizados por medicina interna en nuestra institución se ordena en un alto porcentaje, sin embargo debe ser mejorada. El principal error es la formulación en pacientes con riesgo bajo. La implementación de estrategias para mejorar la tromboprofilaxis logró una mejoría inicial, pero tiende a disminuir con el tiempo. Se requiere un trabajo continuado de múltiples medidas que garanticen su impacto favorable a largo plazo.
Palabras claves: tromboprofilaxis, tromboembolismo venoso, heparinas, prevención, Adherencia
Comparison of wild and domesticated hot peppers fruit: volatile emissions, pungency and protein profiles
Authors: Comparini Diego , Taiti Cosimo , Lanza Matteo , Vita Federico , Pandolfi Camilla , Luti Simone , Spinelli F. , Pazzagli Luigia , Mancuso Stefano 
Published: November 2021

Capsicum plant species are globally cultivated in warm and temperate regions, being important for agro-economic, biological and cultural aspects. While their worldwide spread and their ability of cross-pollination to easily hybridize play an important role in the formation of numerous species and varieties but also create confusion for their classification. For this reason, the categorization of species and varieties is complex and several methods have been used to evaluate pepper plant origin and evolution. Therefore, the objectives of this study were to compare a wild pepper (Capsicum chacoense) with other two domesticated cultivars belonging to different species such as Capsicum annuum and C. baccatum and draw conclusions about their origins using different approaches. For this purpose three methodologies have been used and compared: the comparison of their fruits volatile organic compounds (VOCs) emissions , their capsaicin and dihydrocapsaicin content and the leaves proteomic profiles. The VOCs analysis has been conducted by a time-of-flight mass spectrometry (ToF-MS) with an innovative approach to better identify all the compounds detected, in particular using two different ionization agents (H3O+ and NO+) to better identify all the compounds detected. The VOCs and pungency analyses were then used to build back propagation neural networks (BPNN) and a Random Tree classifier to conduct a multivariate analysis and evaluate the most species-specific volatiles. The outcomes appeared to be a most accurate approach with respect to the traditional varieties descriptors used for peppers discrimination. The BPNN led to the identification of several putative volatiles as good candidates for the recognition of these species or significant nodes in a decision learning tool. Finally, protein profiles have been obtained by SDS-PAGE analysis on the leaves to perform a fast proteomic comparison among the species. The protein profiles showed the C. baccatum and C. chacoense were more similar to the domesticated pepper C. annuum.
Single and combined effects of Bacillus spp. and brown seaweed (Sargassum vulgare) extracts as bio-stimulants of eggplant (Solanum melongena L.) growth
Authors: AYDI BEN ABDALLAH Rania , Ammar Nawaim , Ayed Fakher , Jabnoun-Khiareddine Hayfa , Daami-Remadi Mejda 
Published: November 2021

Bacillus subtilis SV41, B. amyloliquefaciens subsp. plantarum SV65 and Sargassum vulgare extracts were evaluated for their plant growth-promoting potential on eggplant (Solanum melongena L.) plants. Bio-treatments applied singly and/or in combination were further compared to a compost tea and to a commercial bio-fertilizer (Acadian™). Results clearly showed that the combined treatments based on the two Bacillus spp. strains and the aqueous algal extract and the last one mixed with B. amyloliquefaciens subsp. plantarum SV65 induced the highest enhancements in the plant height and the maximum root length which were estimated at 32.4-33.9%, 23.9-25.5% and 23.4-25% and at 36.8-41%, 32.9-37.4% and 36.3-40.5% compared to water, compost tea and Acadian™ based treatments, respectively. Furthermore, the combined treatment based on the aqueous algal extract and B. amyloliquefaciens subsp. plantarum SV65 had significantly improved eggplant growth where the recorded increments in the stem diameter, the aerial part fresh weight, and the root fresh weight varied from 17.5 to 24.6%, 38.4 to 46.1%, and 32.3 to 50% as compared to the three controls, respectively. As for single treatments tested, the aqueous extract had induced a significant improvement in the major growth parameters measured. Developed bio-stimulant was found to be more effective than compost tea and commercial bio-fertilizer based treatments.
Gaia GraL: Gaia DR2 Gravitational Lens Systems. VI. Spectroscopic Confirmation and Modeling of Quadruply Imaged Lensed Quasars
Authors: Stern D. , Djorgovski S. G. , Krone-Martins A. , Sluse D. , Delchambre L. , Ducourant C. , Teixeira R. , Surdej J. , Boehm C. , den Brok J. , Dobie D. , Drake A. , Galluccio L. , Graham M. J. , Jalan P. , Klüter J. , Le Campion J.-F. , Mahabal A. , Mignard F. , Murphy T. , Nierenberg A. , Scarano Jr. S. , Simon J. , Slezak E. , Spindola-Duarte C. , Wambsganss J. 
Published: November 2021

Abstract
Combining the exquisite angular resolution of Gaia with optical light curves and WISE photometry, the Gaia Gravitational Lenses group (GraL) uses machine-learning techniques to identify candidate strongly lensed quasars, and has confirmed over two dozen new strongly lensed quasars from the Gaia Data Release 2. This paper reports on the 12 quadruply imaged quasars identified by this effort to date, which is a ∼20% increase in the total number of confirmed quadruply imaged quasars. We discuss the candidate selection, spectroscopic follow-up, and lens modeling. We also report our spectroscopic failures as an aid for future investigations.
Establishing α Oph as a Prototype Rotator: Precision Orbit with New Keck, CHARA, and RV Observations
Authors: Gardner Tyler , Monnier John D. , Fekel Francis C. , Williamson Michael , Baron Fabien , Hinkley Sasha , Ireland Michael , Kraus Adam L. , Kraus Stefan , Roettenbacher Rachael M. , Schaefer Gail , Sturmann Judit , Sturmann Laszlo , ten Brummelaar Theo 
Published: November 2021

Abstract
Alpha Ophiuchi (Rasalhague) is a nearby rapidly rotating A5IV star that has been imaged by infrared interferometry. α Oph is also part of a known binary system, with a companion semimajor axis of ∼430 mas and a high eccentricity of 0.92. The binary companion provides the unique opportunity to measure the dynamical mass to compare with the results of rapid rotator evolution models. The lack of data near periastron passage limited the precision of mass measurements in previous work. We add new interferometric data from the MIRC combiner at the CHARA Array as well as new Keck adaptive optics imaging data with NIRC2, including epochs taken near periastron passage. We also obtained new radial velocities of both components at Fairborn Observatory. Our updated combined orbit for the system drastically reduces the errors of the orbital elements and allows for precise measurement of the primary star mass at the few percent level. Our resulting primary star mass of 2.20 ± 0.06 M
⊙ agrees well with predictions from imaging results and matches evolution models with rotation when plotting on a Hertzsprung–Russell diagram. However, to truly distinguish between nonrotating and rotating evolution models for this system, we need ∼1% errors on mass, which might be achieved once the distance is known to higher precision in future Gaia releases. We find that the secondary mass of 0.824 ± 0.023 M
⊙ is slightly underluminous when compared to stellar evolution models. We show that α Oph is a useful reference source for programs that need ±1 mas astrometry.
MCMC-based Voigt Profile Fitting to a Mini-BAL System in the Quasar UM 675*

†
Authors: Ishita Dai , Misawa Toru , Itoh Daisuke , Charlton Jane C. , Eracleous Michael 
Published: November 2021

Abstract
We introduce a Bayesian approach coupled with a Markov Chain Monte Carlo method and the maximum-likelihood statistic for fitting the profiles of narrow absorption lines (NALs) in quasar spectra. This method also incorporates the overlap between different absorbers. We illustrate and test this method by fitting models to a “mini-broad” (mini-BAL) and six NAL profiles in four spectra of the quasar UM 675 taken over a rest-frame interval of 4.24 yr. Our fitting results are consistent with past results for the mini-BAL system in this quasar by Hamann et al. We also measure covering factors (C
f) for two narrow components in the C iv and N v mini-BALs and their overlap covering factor with the broad component. We find that C
f (N v) is always larger than C
f (C iv) for the broad component, while the opposite is true for the narrow components in the mini-BAL system. This could be explained if the broad and narrow components originated in gas at different radial distances, but it seems more likely to be due to being produced by gas at the same distance but with different gas densities (i.e., ionization states). The variability detected only in the broad absorption component in the mini-BAL system is probably due to gas motion, since both C
f (C iv) and C
f (N v) vary. We determine for the first time that multiple absorbing clouds (i.e., a broad and two narrow components) overlap along our line of sight. We conclude that the new method improves fitting results considerably compared to previous methods.
Electron Density Dependence of Extreme Ultraviolet Line Intensity Ratios in Ar XIV
Authors: Nakamura Nobuyuki , Numadate Naoki , Kono Yasutaka , Murakami Izumi , Kato Daiji , Sakaue Hiroyuki A. , Hara Hirohisa 
Published: November 2021

Abstract
We report the electron density dependence of extreme ultraviolet line intensity ratios in Ar xiv studied using a well-defined electron beam ion trap plasma. The purpose of this study is to examine the potential of the Ar xiv lines in diagnosing the electron density of solar corona active regions with a temperature higher than 3 MK. The experimentally obtained dependence is in good agreement with collisional-radiative model calculations, which ensures the usability of the Ar xiv lines.
Three-dimensional Core-collapse Supernova Simulations with 160 Isotopic Species Evolved to Shock Breakout
Authors: Sandoval Michael A. , Hix W. Raphael , Messer O. E. Bronson , Lentz Eric J. , Harris J. Austin 
Published: November 2021

Abstract
We present three-dimensional simulations of core-collapse supernovae using the FLASH code that follow the progression of the explosion to the stellar surface, starting from neutrino radiation hydrodynamic simulations of the neutrino-driven phase performed with the Chimera code. We consider a 9.6 M
☉ zero-metallicity progenitor starting from both 2D and 3D Chimera models and a 10 M
☉ solar-metallicity progenitor starting from a 2D Chimera model, all simulated until shock breakout in 3D while tracking 160 nuclear species. The relative velocity difference between the supernova shock and the metal-rich Rayleigh–Taylor (R-T) “bullets” determines how the metal-rich ejecta evolves as it propagates through the density profile of the progenitor and dictates the final morphology of the explosion. We find maximum 56Ni velocities of ∼1950 and ∼1750 km s−1 at shock breakout from 2D and 3D 9.6 M
☉
Chimera models, respectively, due to the bullets’ ability to penetrate the He/H shell. When mapping from 2D, we find that the development of higher-velocity structures is suppressed when the 2D Chimera model and 3D FLASH model meshes are aligned. The development of faster-growing spherical-bubble structures, as opposed to the slower-growing toroidal structure imposed by axisymmetry, allows for interaction of the bullets with the shock and seeds further R-T instabilities at the He/H interface. We see similar effects in the 10 M
☉ model, which achieves maximum 56Ni velocities of ∼2500 km s−1 at shock breakout.
Simultaneous Estimation of Large-scale Structure and Milky Way Dust Extinction from Galaxy Surveys
Authors: Bravo Matías , Gawiser Eric , Padilla Nelson D. , DeRose Joseph , Wechsler Risa H. ,   The LSST Dark Energy Science Collaboration
Published: November 2021

Abstract
The high cosmological precision offered by the next generation of galaxy surveys hinges on improved corrections for Galactic dust extinction. We explore the possibility of estimating both the dust extinction and large-scale structure from a single photometric galaxy survey, making use of the predictable manner in which Milky Way dust affects the measured brightness and colors of galaxies in a given sky location in several redshift bins. To test our method, we use a synthetic catalog from a cosmological simulation designed to model the Vera C. Rubin Observatory Legacy Survey of Space and Time. At high Galactic latitude (∣b∣ ≳ 20°) and a resolution of 1° (

7
′

), we predict the uncertainty in the measurement of dust extinction, E(B − V), to be 0.005 mag (0.015 mag). This is similar to the uncertainty of existing dust maps, illustrating the feasibility of our method. Simultaneous estimation of large-scale structure is predicted to recover the galaxy overdensity δ with a precision of ∼0.01 (∼0.05) at 1° (

7
′

) resolution. We also introduce a Bayesian formalism that combines prior information from existing dust maps with the likelihood of Galactic dust extinction determined from the excursion of observed galaxy properties.
Transport of Interstellar Neutral Helium throughout the Heliosphere
Authors: Fraternale Federico , Pogorelov Nikolai V. , Heerikhuisen Jacob 
Published: November 2021

Abstract
A number of physical processes accompanying the solar wind interaction with the local interstellar medium (LISM) are governed by charge exchange between ions and neutral atoms of interstellar origin. A new, 3D, MHD-plasma/kinetic-neutral model is developed that self-consistently includes both neutral hydrogen and helium atoms, and their feedback on the plasma, through charge exchange and photoionization. Focusing on the transport of interstellar neutral helium, quantitative estimates are provided for bulk properties, deflection angles, and velocity distribution functions (VDFs) along the upwind direction. It is shown that the average deflection of secondary He atoms born in the outer heliosheath (OHS) from their original direction in the LISM is ∼12° in front of the heliopause, and occurs in the directions parallel to the plane formed by the velocity and magnetic field vectors in the unperturbed LISM. While these properties are consistent with Interstellar Boundary Explorer observations of the “warm breeze,” we show that charge exchange in the OHS leads to remarkable deviations of their VDF from the Maxwellian distribution. He atom filtration in the OHS results in a significant temperature anisotropy and VDF asymmetries, even for the primary helium atoms that experience no charge exchange at all. This is an entirely kinetic phenomenon that shows that primary He atoms observed at 1 au have distributions substantially different from those in the LISM.
Rapid Evolution of Bald Patches in a Major Solar Eruption
Authors: Lee Jonathan H. , Sun (孙旭东) Xudong , Kazachenko Maria D. 
Published: November 2021

Abstract
A bald patch (BP) is a magnetic topological feature where U-shaped field lines turn tangent to the photosphere. Field lines threading the BP trace a separatrix surface where reconnection preferentially occurs. Here we study the evolution of multiple, strong-field BPs in AR 12673 during the most intense, X9.3 flare of solar cycle 24. The central BP, located between the initial flare ribbons, largely “disintegrated” within 35 minutes. The more remote, southern BP survived. The disintegration manifested as a 9° rotation of the median shear angle; the perpendicular component of the horizontal field (with respect to the polarity inversion line) changed sign. The parallel component exhibited a step-wise, permanent increase of 1 kG, consistent with previous observations of the flare-related “magnetic imprint.” The observations suggest that magnetic reconnection during a major eruption may involve entire BP separatrices, leading to a change of magnetic topology from BPs to sheared arcades.
A High-velocity Scatterer Revealed in the Thinning Ejecta of a Type II Supernova
Authors: Leonard Douglas C. , Dessart Luc , Hillier D. John , Pignata Giuliano , Williams G. Grant , Hoffman Jennifer L. , Milne Peter , Smith Nathan , Smith Paul S. , Khandrika Harish G. 
Published: November 2021

Abstract
We present deep, nebular-phase spectropolarimetry of the Type II-P/L SN 2013ej, obtained 167 days after explosion with the European Southern Observatory’s Very Large Telescope. The polarized flux spectrum appears as a nearly perfect (92% correlation), redshifted (by ∼4000 km s−1) replica of the total flux spectrum. Such a striking correspondence has never been observed before in nebular-phase supernova spectropolarimetry, although data capable of revealing it have heretofore been only rarely obtained. Through comparison with 2D polarized radiative transfer simulations of stellar explosions, we demonstrate that localized ionization produced by the decay of a high-velocity, spatially confined clump of radioactive 56Ni—synthesized by and launched as part of the explosion with final radial velocity exceeding 4500 km s−1—can reproduce the observations through enhanced electron scattering. Additional data taken earlier in the nebular phase (day 134) yield a similarly strong correlation (84%) and redshift, whereas photospheric-phase epochs that sample days 8 through 97 do not. This suggests that the primary polarization signatures of the high-velocity scattering source only come to dominate once the thick, initially opaque hydrogen envelope has turned sufficiently transparent. This detection in an otherwise fairly typical core-collapse supernova adds to the growing body of evidence supporting strong asymmetries across nature’s most common types of stellar explosions, and establishes the power of polarized flux—and the specific information encoded by it in line photons at nebular epochs—as a vital tool in such investigations going forward.
Some novel hybrid quinazoline-based heterocycles as potent cytotoxic agents
Authors: Malekzadeh Mahla , Dadkhah Shadi , Khodarahmi Ghadam Ali , Asadi Parvin , Hassanzadeh Farshid , Rostami Mahboubeh 
Published: November 2021

Background and purpose:
In this study, some new cytotoxic hybrid structures were synthesized by combining pyrazolinone and imidazolinone rings with quinazoline pharmacophores.

Experimental approach:
The benzoxazinone, pyrazolo-quinazoline fused ring, and imidazolinone anchored quinazoline derivatives were synthesized by simple ring-opening, ring expansion, and ring closure strategies from oxazolones. The molecular docking studies of the final derivatives were accomplished on the epidermal growth factor receptor enzyme. The cytotoxic effect of the final compounds on the MCF-7 cell line was evaluated by MTT assay.

Findings/Results:
The docking results confirmed the optimized electrostatic, H-bonding, and hydrophobic interactions of structures with the key residues of the active site (ΔGbin< -9Kcal/mol). The derivatives have been obtained in good yield and purity, and their structures were confirmed by different methods (FT-IR, 1H-NMR, 13C-NMR, and CHNS analysis). The IC50s of all final derivatives against the MCF-7 cell line were lower than 10 μM, and between all, the IXa from pyrazolo-quinazolinone class (IC50: 6.43 μM) with chlorine substitute was the most potent. Furthermore, all derivatives showed negligible cytotoxicity on HUVEC normal cell line which would be a great achievement for a novel cytotoxic agent.

Conclusion and implications:
Based on the obtained results, pyrazolo[1,5-c] quinazolin-2-one series were more cytotoxic than imidazolinone methyl quinazoline-4(3H)-ones against MCF-7 cells. Chlorine substitute in the para position of the aromatic ring improved the cytotoxicity effect in both classes. It could be related to the polarizability of a chlorine atom and making better intermolecular interactions. Further pre-clinical evaluations are required for the promising synthesized cytotoxic compounds.