bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional Printed Polylactic Acid and Hydroxyapatite Composite Scaffold with Urine-derived Stem Cells Treatment for Bone Defects
Authors: Zhang Xiang , Chen Jialei , Wang Hongren , Duan Xin , Gao Feng 
Published: November 2021

Abstract
BACKGROUND: Bone defects still pose various challenges in osteology. As one of the treatment options for bone defects, bone tissue engineering requires biomaterials with good biocompatibility and seed cells with good differentiation capacity. This study aimed to fabricate a 3D-printed polylactic acid and hydroxyapatite (PLA/HA) composite scaffold with urine-derived stem cells (USCs) to study its therapeutic effect in a model of skull defect in rats.METHODS: USCs, isolated and extracted from the urine of healthy adult males, were inoculated onto a 3D-printed PLA/HA composite scaffold and a PLA scaffold. Skull defect model rats were randomly divided into three groups (control, PLA, and PLA/HA). Twelve weeks after implanting scaffolds containing USCs into rats with a skull defect, the therapeutic efficacy was evaluated by real-time PCR, micro-CT, histology, and immunohistochemistry.RESULTS: The 3D-printed PLA/HA composite scaffold had good mechanical properties and porosity. The adhesion and proliferation of USCs on scaffolds also demonstrated excellent biocompatibility. PLA and PLA/HA containing USCs promoted bone regeneration in the defect area, supported by the general observation and CT images at 12 weeks after treatment, with coverage of 74.6%±1.9% and 96.7%±1.6%, respectively. Immunohistochemical staining showed a progressive process of new bone formation on PLA/HA scaffolds containing USCs at the defect site compared to that in PLA and control groups.CONCLUSION: The 3D-printed PLA/HA composite scaffold with USCs was successfully applied to the skull defect in rats. Under the linkage of the scaffold, the proliferation, differentiation, and osteogenesis expression of USCs were promoted near the bone defect area. These findings demonstrated broad application prospects of PLA/HA scaffolds with USCs in bone tissue engineering.
Integration of Systematic Screening For Tuberculosis in Outpatient Departments of Urban Primary Health-Care Facilities in Zambia: A Case Study of Kitwe District
Authors: Zulu Davy Wadula , Silumbwe Adam , Maritim Patricia , Zulu Joseph Mumba 
Published: November 2021

Abstract
Background: Tuberculosis (TB) is the leading cause of death from a single infectious agent globally, yet 3 million cases are missed every year. The World Health Organization recommends systematic screening of suspected active TB patients among those visiting the healthcare facilities. While many countries have scaled-up systematic screening of TB, there has been limited assessment of the extent of its integration into the health system. This study sought to explore factors that shaped the integration of systematic screening of TB in outpatient departments of primary healthcare facilities in Kitwe district, Zambia. Methods: This was a qualitative case study with health providers including district managers, TB focal point persons and laboratory personnel working in six purposively selected primary healthcare facilities. Data was collected through key informant (n=8) and in-depth (n=15) interviews. Data analysis was conducted using QDA Miner software and guided by Atun’s Integration framework.Results: Integration was facilitated by perceptions of the magnitude of the TB burden, alignment of the intervention with national TB aspirations, knowledge of stakeholder interests, power and values, regular performance management and intra-facility collaboration. Constraining factors included external partners’ influence in the TB screening program, unbalanced incentivization mechanisms, donor-driven financing and social determinants of health such as gender and stigma including the COVID-19 pandemic.Conclusion: Systematic screening of TB is not well integrated into the primary healthcare facilities to capture all those suspected with active TB that make contact with the health system. Finding the missing TB cases will, therefore, require contextual adaptation of the systematic screening for TB and strengthening the health system.
Expansion of detectable area by floating electrodes in capacitive three-dimensional proximity sensor
Authors: Deguchi M. 
Published: November 2021

Abstract
In the capacitive proximity sensing method, arranging multiple sensing electrodes makes it possible to obtain the three-dimensional position of a nearby object. The author has developed a capacitive proximity sensing method using LC resonance in three reactance elements. In this method, the detectable area can be greatly extended by the floating electrodes, which are capacitively connected to the sensing electrode. By connecting multiple floating electrodes in series, the detectable range can be extended up to the length of the array of floating electrodes. When these electrodes are arranged on a frame, the region surrounded by the frame becomes the detectable area. By applying this frame on any surface, it is possible to make the surface within the opening of the frame a non-contact operating panel, which can be applied as a gesture input device.
Plant Art from the Amazon: Tree Performance in the Work of Frans Krajcberg
Authors: Vieira Patrícia 
Published: November 2021

This article examines plant performance in the work of naturalized Brazilian artist Frans Krajcberg (1921-2017). Krajcberg saw his art as a way to give voice to forest plants that are being systematically destroyed through fires and logging, to give way to agribusiness ventures. He used burnt trunks of Amazonian trees he collected after forest fires to create a series of sculptures that denounced the environmental crimes taking place in the region. I resort to biosemiotics, New Materialism and Indigenous, peasant and riverine Amazonian thought as possible theoretical frameworks to interpret Krajcberg's sculptures as a human/plant collaboration that questions species divides and even the boundaries between living and non-living matter. The import of his pieces is clear: the bodies of the dead and charred trees are given a new life in Krajcberg’s work that incorporates them and turns them into art. I argue that his artworks are a fusion between the bare physically of the dead trees that speak to us through their materiality and the artist’s craft. The trees are very clearly inscribed into the sculptures that allow them to speak from beyond their grave, as it were, and to become living symbols of the destruction of the Amazon rainforest.
Adoption behavior of water efficiency labeling: origin, research progress and theoretical framework – evidence from China
Authors: Liang Jingru , Zhang Shujing , Wang Han , Du Peijie , Wang Yanrong 
Published: November 2021

Abstract
Research on the adoption behavior of water efficiency labeling is of great significance for improving citizens' water-saving consciousness and promoting water-saving techniques and standards. This study sorted out 559 papers about adoption behavior and then systematically analyzed the origin and research progress of water efficiency labeling in different fields. Finally, related theories and empirical analysis are integrated, and a research framework of ‘gold ingot’ that focuses on adoption behavior is constructed. The study found that the research mainly involves three contents in the current: adoption behavior of corporate users, adoption behavior of rural households and adoption behavior of individual users. Based on the above literature analysis, this study proposes a theoretical framework for research on the adoption behavior of water efficiency labeling.
Mutual Effects of Free and Nanoencapsulated Phenolic Compounds
on Human Microbiota
Authors: Cassini Carina , Zatti Pedro Henrique , Angeli Valéria Weiss , Branco Catia Santos , Salvador Mirian 
Published: November 2021

:
Phenolic compounds (PC) have many health benefits such as antioxidant, anticarcinogenic,
neuroprotective, and anti-inflammatory activities. All of these activities depend
on their chemical structures and their interaction with biological targets in the body.
PC occur naturally in polymerized form, linked to glycosides and require metabolic transformation
from their ingestion to their absorption. The gut microbiota can transform PC
into more easily absorbed metabolites. PC, in turn, have prebiotic and antimicrobial actions
on the microbiota. Despite this, their low oral bioavailability still compromises biological
performance. Therefore, the use of nanocarriers has been demonstrated to be a
useful strategy to improve PC absorption and, consequently, their health effects. Nanotechnology
is an excellent alternative able to overcome the limits of oral bioavailability of
PC, since it offers protection from degradation during their passage through the gastrointestinal
tract. Moreover, nanotechnology is also capable of promoting controlled PC release
and modulating the interaction between PC and the microbiota. However, little is
known about the impact of nanotechnology on PC effects on the gut microbiota. This review
highlights the use of nanotechnology for PC delivery on gut microbiota, focusing on
the ability of such formulations to enhance oral bioavailability by applying nanocarriers
(polymeric nanoparticles, nanostructured lipid carriers, solid lipid nanoparticles). In addition,
the effects of free and nanocarried PC or nanocarriers per se on gut microbiota are
also described.
New Mechanisms and Targets of Subarachnoid Hemorrhage: A Focus on
Mitochondria
Authors: Zhang Zeyu , Zhang Anke , Liu Yibo , Hu Xiaoming , Fang Yuanjian , Wang Xiaoyu , Luo Yujie , Lenahan Cameron , Chen Sheng 
Published: November 2021

:
Spontaneous subarachnoid hemorrhage (SAH) accounts for 5-10% of all strokes and is a
subtype of hemorrhagic stroke that places a heavy burden on health care. Despite great progress in
surgical clipping and endovascular treatment for ruptured aneurysms, cerebral vasospasm (CVS)
and delayed cerebral ischemia (DCI) threaten the long-term outcomes of patients with SAH. Moreover,
there are limited drugs available to reduce the risk of DCI and adverse outcomes in SAH patients.
New insight suggests that early brain injury (EBI), which occurs within 72 h after the onset of
SAH, may lay the foundation for further DCI development and poor outcomes. The mechanisms of
EBI mainly include excitotoxicity, oxidative stress, neuroinflammation, blood-brain barrier (BBB)
destruction, and cellular death. Mitochondria are a double-membrane organelle, and they play an
important role in energy production, cell growth, differentiation, apoptosis, and survival. Mitochondrial
dysfunction, which can lead to mitochondrial membrane potential (ΔΨm) collapse, overproduction
of reactive oxygen species (ROS), release of apoptogenic proteins, disorders of mitochondrial
dynamics, and activation of mitochondria-related inflammation, is considered a novel mechanism
of EBI related to DCI as well as post-SAH outcomes. In addition, mitophagy is activated after
SAH. In this review, we discuss the latest perspectives on the role of mitochondria in EBI and DCI
after SAH. We emphasize the potential of mitochondria as therapeutic targets and summarize the
promising therapeutic strategies targeting mitochondria for SAH.
Transgenerational Abnormalities Induced by Paternal Preconceptual
Alcohol Drinking: Findings from Humans and Animal Models
Authors: Terracina Sergio , Ferraguti Giampiero , Tarani Luigi , Messina Marisa Patrizia , Lucarelli Marco , Vitali Mario , De Persis Simone , Greco Antonio , Minni Antonio , Polimeni Antonella , Ceccanti Mauro , Petrella Carla , Fiore Marco 
Published: November 2021

:
Alcohol consumption during pregnancy and lactation is a widespread preventable cause of neurodevelopmental impairment in newborns. While the harmful effects of gestational alcohol use have been well documented, only recently the role of paternal preconceptual alcohol consumption (PPAC) prior to copulating has drawn specific epigenetic considerations. Solid human and animal model data demonstrated that PPAC may affect sperm function eliciting oxidative stress. In newborns, PPAC may induce changes in the behavior, cognitive functions and emotional responses. Furthermore, PPAC may elicit neurobiological disruptions, visuospatial impairments, hyperactivity disorders, motor skill disruptions, hearing loss, endocrine and immune alterations, reduced physical growth, placental disruptions and metabolic alterations. Neurobiological studies on PPAC disclosed also changes in brain function and structure by the disruption of the growth factors pathways. In particular, as shown in animal model studies PPAC alters brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) synthesis and release. This review shows that the crucial topic of lifelong disabilities induced by PPAC and/or gestational alcohol drinking is quite challenging at the individual, societal, and familial levels. Since a nontoxic drinking behavior before pregnancy (for both men and women) during pregnancy and lactation cannot be established the only suggestion for couples planning pregnancies is to completely avoid the consumption of alcoholic beverages.
flexible-learning journey
Authors: Talosa Arlene D. , Javier Billy S. , Dirain Estela L. 
Published: November 2021

Philippine higher education has been driven by the urgency of alternative learning modalities from traditional to flexible teaching and learning. Much research has already been embarked on flexible learning. New to the platform, this study purports to document and describe the learning opportunities and influencing factors on the self-efficacy of students in a flexible learning set-up. Using In-depth individual interviews as its method, the qualitative study was administered to higher education students who consented to take part in the study. Findings revealed that self-regulated learning and digital or technological self-efficacy are the two themes found as a learning opportunity with the current learning modality. Personal, Technological, Communication, Home Environment, and Teacher-related are the overarching themes that emerged as influencing factors. The findings of this study have generated several implications for teaching practice, technology experts, and other stakeholders that must be considered very seriously as they represent the opinion of the users of flexible learning.
Consumer behavior-focused training in retailing education: Too much of a good thing?
Authors: Hendarsjah Hidajat , Haryanto Haryanto 
Published: November 2021

Consumer behavior training extensively delivered in the tertiary vocational school of business had been expected to equip students with deep knowledge in marketing and sales. This was true when students were dealing with general business environments, but it was dubious when it was implemented in a certain field of business, such as retail business. Retail business, predictably, had a unique characteristic in its business decisions. Students in the Marketing Program of a tertiary vocational school in their final year were the object of the study. Employing the non-parametric tools to assess student knowledge in consumer behavior and its association with retailing decisions mastery, it was found that student mastery in consumer behavior did not associate with better knowledge in other five retail business decisions (determining the composition of goods, spotting locations, pricing, profit strategy, and store management). The article also provided a brief explanation that specific knowledge in consumer behavior did not always in line with the required knowledge in the retail business. It was also suggested that to elaborate whether one particular knowledge of business practices had a valuable feature was, first, by determining its overall decisions relating to it. Then, the second, establishing a series of analyses to assess whether the decisions have any relations with the college’s courses or training of a field of study. Comprehension of the process might help the vocational school to equip students with the right required knowledge and skills for a certain field of business.
Aktivitas Belajar dan Perilaku Kerja Inovatif pada Masa Pandemi Dimediasi oleh Efikasi-Diri Inovasi
Authors: Ardini Dhea Rizky , Etikariena Arum 
Published: November 2021

Perilaku kerja inovatif telah diteliti sebagai salah satu hal yang berguna bagi keberlangsungan perusahaan di masa pandemi Covid-19. Namun, perubahan pada berbagai aspek dalam lingkungan kerja akibat penyebaran Covid-19 menimbulkan tantangan bagi karyawan untuk menampilkan perilaku inovatif. Diduga bahwa keyakinan individu untuk berinovasi dapat membantu karyawan untuk dapat konsisten memberikan performa terbaiknya dengan menampilkan perilaku inovatif di masa pandemi Covid-19. Penelitian ini bertujuan untuk melihat peran efikasi-diri inovasi sebagai variabel mediator dalam hubungan antara aktivitas belajar formal maupun informal terhadap perilaku kerja inovatif karyawan. Responden penelitian ini merupakan karyawan dengan rentang usia 24-44 tahun yang bekerja di area Jabodetabek dengan masa kerja minimal 1 tahun dan pendidikan terakhir minimal S-1. Skala yang digunakan adalah Skala Aktivitas Belajar Formal, Skala Aktivitas Belajar Informal, Skala Efikasi-Diri Inovasi, dan Skala Perilaku Kerja Inovatif. Studi kuantitatif dilakukan terhadap 165 responden menggunakan metode accidental sampling. Metode penelitian ini menggunakan metode survei dengan menyebarkan kuesioner daring. Untuk pengolahan data menggunakan analisis regresi mediasi dengan aplikasi statistik SPSS 25 PROCESS. Hasil analisis data menunjukkan bahwa efikasi diri inovasi memediasi sebagian hubungan antara aktivitas belajar formal dan informal dengan perilaku kerja inovatif. Hasil penelitian ini memberikan implikasi positif kepada karyawan, penyelia, maupun perusahaan.
Strategi Pengembangan Masyarakat Petani Lahan Gambut melalui Program Tanggung Jawab Sosial Perusahaan: Analisis Pendekatan Penghidupan Berkelanjutan
Authors: Fatkhullah Mukhammad , Mulyani Iwed , Imawan Bambang 
Published: November 2021

Indonesia memiliki kontribusi pada perubahan iklim global melalui lahan gambut yang tersebar dari Sumatra, Kalimantan, hingga Papua. Sayangnya, pengelolaan lahan gambut di Indonesia belum mengindahkan aspek keberlanjutan. Hal ini berkaitan erat dengan kemiskinan dan keterbelakangan masyarakat petani. Penelitian ini berfokus untuk melihat bagaimana strategi pengembangan masyarakat petani lahan gambut dengan menggunakan pendekatan penghidupan berkelanjutan melalui program Desa Wisata Gambut Sejahtera (DEWIGATRA). Hasilnya, DEWIGATRA berhasil menyejahterakan kelompok petani lahan gambut melalui dua cara. Pertama, mitigasi kebencanaan melalui peningkatan kualitas modal social, human dan physical. Hal ini diwujudkan dengan melakukan reintegrasi kelompok Masyarakat Peduli Api, pelaksanaan pelatihan mitigasi bencana karhutla, serta pengadaan sarana dan prasarana berupa alat pemadam dan embung. Kedua, pengembangan modal natural dan financial melalui program pemberdayaan. Upaya ini dilakukan dengan mengubah sistem pertanian dengan menghadirkan inovasi drip irrigation system.
Kata kunci: Pengembangan Masyarakat, Petani Lahan Gambut, Penghidupan Berkelanjutan

Indonesia has an important role in global climate change because of its peatlands that spread from Sumatra, Kalimantan to Papua. Unfortunately, peatland management in Indonesia has not heeded the sustainability aspect. This is closely related to the poverty and backwardness of the farming community. This study aims to determine the development strategy of peatland farming communities with using a sustainable livelihood approach through Desa Wisata Gambut Sejahtera (DEWIGATRA) program. As a result, DEWIGATRA prospered peatland farmer groups in two ways. First, disaster mitigation through improving the quality of social, human and physical capital. This is realized by reintegrating the Fire Care Community group, implementing forest fire disaster mitigation training, as well as providing facilities and infrastructure in the form of fire extinguishers and reservoirs. Second, increasing natural and financial capital through empowerment programs. This effort is carried out by changing the agricultural system by introducing the drip irrigation system innovation.
Keywords: Community Development, Peatland Farmer, Sustainable Livelihood
The Prospects and Challenges of Economic Liberalization in Reducing Poverty and Inequality in Indonesia
Authors: Alfath Bagus Panuntun El Nur Indonesia  
Published: November 2021

This article discusses whether economic liberalisation policies have succeeded in alleviating poverty and inequality in Indonesia. In addition, this article aims to provide alternative policies to strengthen Indonesia’s bargaining position in international trade forums by shifting the extractive industry to knowledge-based industries and fixing the fragile social protection system when faced with COVID-19. This article is written descriptively and analytically based on various data, such as literature, planning documents, news reports, and other sources. Despite the prospect of economic liberalisation, the findings show Indonesia has three main problems: statistical data that does not reflect reality, overlapping regulations, and weak governance. This article offers several policy recommendations that need improvement based on the “Going for Growth” framework.
Keywords: economic liberalisation, poverty alleviation, inequality, social protection, and going for growth

Tulisan ini mendiskusikan apakah kebijakan liberalisasi ekonomi berhasil dalam pengentasan kemiskinan dan ketimpangan di Indonesia. Selain itu, tulisan ini bertujuan untuk memberikan alternatif kebijakan dalam rangka memperkuat posisi tawar Indonesia dalam forum perdagangan internasional dengan menggeser industri ekstraktif ke industri berbasis pengetahuan, sekaligus membenahi sistem perlindungan sosial yang rapuh ketika dihadapkan pada COVID-19. Tulisan ini ditulis secara deskriptif dan analitis berdasarkan dukungan dari berbagai data, seperti literatur, dokumen perencanaan, laporan berita, dan sumber lainnya. Meskipun terdapat prospek dari liberalisasi ekonomi, temuan menunjukkan bahwa Indonesia memiliki tiga masalah utama: data statistik yang tidak mencerminkan realitas, regulasi yang tumpang tindih, dan lemahnya tata kelola pemerintahan. Tulisan ini menawarkan beberapa rekomendasi kebijakan yang perlu ditingkatkan berdasarkan kerangka berpikir “Going for Growth”.
Kata kunci: liberalisasi ekonomi, pengentasan kemiskinan, ketimpangan, perlindungan sosial dan going for growth
SPEECH, MOCKERY, AND SINCERE CONCERN
Authors: Kaplan Jeffrey 
Published: November 2021

Abstract
This paper offers an account of a phenomenon that seems increasingly common in public discourse: trolling. The term “troll” is colloquial, and no formal synonym exists in English. But the informality of the term should not mislead us into thinking that the underlying concept is so unimportant as to be unworthy of philosophical attention or so ill-behaved as to be resistant to philosophical analysis. This paper presents such an analysis.