bluuebunny/crossref_metadata_2025_split huggingface dataset:
APRESENTAÇÃO: Memórias de processos de renovação pedagógica no Brasil
Authors: Sylvia Vidigal Moraes Carmen , Dos Santos Braga Elizabeth , Cleber Dias de Menezes Roni 
Published: March 2021

O presente dossiê pretende problematizar aspectos da história dos processos de renovação pedagógica e modernização institucional da educação pública brasileira. Para tal, elegeram-se estabelecimentos exponenciais da Universidade de São Paulo (1934) que guardam em diferentes momentos de suas trajetórias, a começar pelas feições adotadas e finalidades atribuídas desde suas respectivas fundações, signos marcantes dos discursos e projetos de transformação dos atuais níveis de ensino fundamental, médio e superior. Trata-se da Escola de Aplicação da Faculdade de Educação da Universidade de São Paulo (EA-Feusp), surgida em 1959, e da própria Faculdade de Educação da Universidade de São Paulo (Feusp), originária do Departamento de Educação da FFCL-USP e erigida em unidade de ensino em 1969, todos eles relacionados ao Centro Regional de Pesquisas Educacionais de São Paulo/CRPE-SP (1956), organizado pelo Instituto Nacional de Pesquisas Educacionais/INEP na gestão de Anísio Teixeira (1952-1964).
Tal escolha se prende, por um lado, à instigante tarefa a que se entregaram docentes, alunos, funcionários e pesquisadores das duas instituições por ocasião das comemorações dos 60 e 50 anos, respectivamente, de criação de ambas as instituições, quando uma série de atividades, especialmente ligadas à produção e evocação de memórias, animaram todo o ano de 2019. Por outro, o conjunto de textos busca explorar a irrupção no cenário educacional de inovações e reformas que redimensionaram os traços da educação no país nos últimos 60 anos, logrando tal empreendimento pelo exame dos estímulos e rebatimentos de tais transformações tendo os estabelecimentos mencionados como atores privilegiados no curso de tais mudanças.
Corona children studies "Co-Ki": First results of a Germany-wide registry on mouth and nose covering (mask) in children
Authors: Schwarz Silke , Jenetzky Ekkehart , Krafft Hanno , Maurer Tobias , Martin David 
Published: March 2021

Abstract

Background: Narratives about complaints in children and adolescents caused by wearing a mask are accumulating. There is, to date, no registry for side effects of masks.Methods: At the University of Witten/Herdecke an online registry has been set up where parents, doctors, pedagogues and others can enter their observations. On 20.10.2020, 363 doctors were asked to make entries and to make parents and teachers aware of the registry. Results: By 26.10.2020 the registry had been used by 20,353 people. In this publication we report the results from the parents, who entered data on a total of 25,930 children. The average wearing time of the mask was 270 minutes per day. Impairments caused by wearing the mask were reported by 68% of the parents. These included irritability (60%), headache (53%), difficulty concentrating (50%), less happiness (49%), reluctance to go to school/kindergarten (44%), malaise (42%) impaired learning (38%) and drowsiness or fatigue (37%).Discussion: This world's first registry for recording the effects of wearing masks in children is dedicated to a new research question. Bias with respect to preferential documentation of children who are particularly severely affected or who are fundamentally critical of protective measures cannot be dismissed. The frequency of the registry’s use and the spectrum of symptoms registryed indicate the importance of the topic and call for representative surveys, randomized controlled trials with various masks and a renewed risk-benefit assessment for the vulnerable group of children: adults need to collecticely reflect the circumstances under which they would be willing to take a residual risk upon themselves in favor of enabling children to have a higher quality of life without having to wear a mask.
Radiographic Features and Prognosis of Early- and Late-onset Non-small Cell Lung Cancer Immune Checkpoint Inhibitor-related Pneumonitis
Authors: Huang Aiben , Xu Yang , Zang Xuelei , Wu Chongchong , Gao Jie , Sun Xiaoli , Xie Mei , Ma Xidong , Deng Hui , Song Jialin , Ren Fangping , Pang Li , Qian Jin , Yu Zhaofeng , Wan Shiyu , Chen Yuanyuan , Pan Lei , Zhuang Guanglei , Liu Sanhong , Xue Xinying 
Published: March 2021

Abstract
Background: Immunotherapy is becoming a standard of care for non-small cell lung cancer (NSCLC). Checkpoint inhibitor-associated pneumonia (CIP) is a rare and potentially life-threatening event that can occur at any time during tumor immunotherapy. However, there may be differences in the radiological patterns and prognosis of CIP during different periods. This study aimed to investigate the radiographic features and prognosis of early- and late-onset immune-related pneumonitis. Methods: We retrospectively analyzed the clinical data of 677 NSCLC patients receiving immunotherapy to identify 32 patients with CIP who were being effectively treated by hormonotherapy, analyzed the clinical and radiographic data, and summarized the radiological features and prognosis of early- and late-onset CIP. Results: CIP had an incidence of 4.7%, a median onset time of 2.4 months, and a mortality of 28.1%. Among these, CIP included 14 early-onset cases, where grade ≥3 CIP accounted for 92.9%, main radiographic pattern was organizing pneumonia (OP)-like pattern, and mortality was 50.0%. We also identified 18 late-onset CIPs, where grade ≥3 CIP accounted for 50.0%, main radiographic pattern was nonspecific interstitial pneumonia (NSIP)-like pattern, and mortality was 11.1%. The overall survival rate of the early-onset group was significantly lower than that of the late-onset group (P < 0.05).Conclusion: Early-onset CIP cases were higher in the National Comprehensive Cancer Network (NCCN) grade and mainly presented with an OP-like radiographic pattern; whereas, late-onset CIP cases were lower in NCCN grade and mainly presented with an NSIP-like radiographic pattern. Finally, the prognosis of the early-onset CIP group was poorer than that of the late-onset CIP group. We believe that this study will be helpful for clinicians for making early diagnosis and deciding treatment modalities for patients with CIP.
Whole Transcriptome Analysis on Sepsis Caused by Pyogenic Liver Abscess
Authors: Zhao Ding , Liu Jia , Han Dong-feng , Li Xing-liang , Chen Jian , Li Wei , Xing Ji-hong , Sun Lichao 
Published: March 2021

Abstract
Background

Pyogenic liver abscess (PLA) is a common clinical disease throughout the world with remaining high mortality and morbidity. This study sought to investigate key genes and non-coding RNAs (ncRNAs) associated with the pathogenesis and treatment of sepsis caused by PLA (SLA).
Methods

We constructed the expression profiles of RNAs by RNA sequencing in the peripheral blood of healthy subjects, SLA and seven day therapy of SLA patients. Then the sequencing data was analysed through integrated bioinformatics strategy.
Results

4549 mRNAs, 9808 lncRNAs, 467 circRNAs and 292 miRNAs were differentially expressed (DE) between SLA and control samples. 3199 mRNAs, 6018 lncRNAs, 161 circRNAs and 132 miRNAs were differentially expressed between SLA after 7 days therapy and SLA control subjects. Moreover, DE mRNAs of the former two comparisons were both related to immunity and T cell-mediated immune response; DE lncRNAs were both associated with B cell receptor signaling pathway and Osteoclast differentiation; DE circRNAs were both related to Chagas disease and B cell receptor signaling pathway; DE miRNAs exerts its specific role in the process of SLA by MAPK signaling pathway and Estrogen signaling pathway compared to DE lncRNAs, circRNAs and mRNAs. Finally, lncRNA/circRNA–miRNA–mRNA network was constructed to explore the internal regulating relationships of these ncRNAs and mRNAs.
Conclusions

Our results may provide a new perspective on differential RNA expression involved in the pathogenesis and treatment of SLA and accelerate the development of novel treatments for this disease.
Asymmetrically Wettability Janus Cotton Fabrics Fabricated via Interfacial Ion Migration for Surfactant-stabilized Oil-in-water Emulsions
Authors: Yang Pu , Hu Ruimin , Yu Bin , Sun Yiwei , Liu Yiping , Lu Ming 
Published: March 2021

Abstract
Separation of surfactant-stabilized oil-water emulsions seems to be challenging owing to its diverse repercussions on environment and human life. The asymmetrical wettability Janus cotton fabric (J-MH@CF) with high separation performance was prepared by two-step method, which related to interfacial ion migration technology and unilateral spraying treatment. In detail, the immobilization of magnesium hydroxide (Mg(OH)2) caused the formation of the rough micro/nanostructure of cotton fabric surface, which was helpful to superhydrophilic property. Stearic acid as a coating created the unilateral superhydrophobic surface with low surface energy. J-MH@CF showed asymmetric wettability, featuring diode-like directional water transmission. Wettability, directional transmission and separation performance of J-MH@CF membrane were investigated systematically. The asymmetric wettability architecture was demonstrated to play a key role in separating surfactant-stabilized oil-in-water emulsions. Impressingly, the separation performance was not affected by the type of surfactants. For emulsion stabilized by sodium dodecyl sulfate (SDS), the separation flux driven by gravity was approximately 500 L m-2h-1, and all separation efficiencies were over 99.3%. CTAB/Oil/H2O emulsion and the Tween-60/Oil/H2O emulsion also could be successfully separated with high separation efficiency and separation flux. During the whole separation process, the oil droplets surrounded by surfactants (Oil-Ss) were difficult to demulsify and gathered on the surface of the fabric to form a "creamy layer", which was beneficial to improve separation efficiency and could be cleaned off so that J-MH@CF membrane was not contaminated. In addition, the J-MH@CF membrane exhibited robust reusability for separation, which was promising for remediation of oily wastewater containing surfactants.
Association of Urinary Sodium Excretion and Left Ventricular Hypertrophy in Patients With Type 2 Diabetes: A Cross-Section Study
Authors: Liu Jianfang , Guo Dan , Zhang Peizhen , Yang Xiaoyu , Lin Jiayang , Liu Deying , Wei Xueyun , Xu Bingyan , Huang Chensihan , Yang Linjie , Lei Xuzhen , Yang Zhi , Huang Junlin , Xue Yaoming , Zhang Huijie 
Published: March 2021

Abstract
Background: It has been well documented that left ventricular hypertrophy (LVH) is highly associated with incidence of cardiovascular disease (CVD). Evidence indicated that high sodium intake has been observed related with LVH in general population. However, information is not available regarding the association between urinary sodium excretion and LVH in patients with type 2 diabetes (T2DM). This study aimed to explore the association between urinary sodium excretion and LVH in patients with T2DM.Methods: A total of 1356 patients with T2DM were recruited. Urinary sodium was measured from 24-hour urine samples of inpatients and morning fasting urine samples of outpatients. LVH was assessed by echocardiography. The associations between urinary sodium excretion and the risk factors for cardiovascular events, LVH and left ventricular mass index (LVMI) were examined using linear regression analysis, logistic regression and restricted cubic splines.Results: Urinary sodium excretion levels was positively associated with cardiometabolic risk factors, including systolic blood pressure (P<0.001), body mass index (P<0.001), waist circumference (P<0.001) and LVMI (P<0.001). In multivariable logistic regression analyses, increased urinary sodium excretion were significantly associated with increased risks of LVH [OR (95% CI), 1.47 (1.02-2.10); P=0.037] and CVD [OR (95% CI), 2.08 (1.20-3.61); P=0.009], after adjusted for demographics, lifestyle risk factors and cardiovascular risk factors. Multivariable-adjusted restricted cubic spline analyses of the association between urinary sodium excretion and LVMI showed a significant association (P=0.002) and provided no evidence of a nonlinear association (P=0.135).Conclusions: This study indicated that high urinary sodium excretion was independently associated with increased risk of LVH and CVD in patients with T2DM, suggesting that control of sodium intake is valuable in the prevention of diabetic cardiovascular complications.
Associations Between Socioeconomic Status and Adverse Pregnancy Outcomes: A Greater Magnitude of Perinatal Inequities in Montreal Than in Brussels
Authors: Sow Mouctar , Raynault Marie-France , Spiegelaere Myriam 
Published: March 2021

Abstract
Objective This paper compares the associations between socioeconomic status (SES) and 1) low birth weight (LBW) and 2) preterm birth, in Brussels and Montreal, and discusses hypotheses that may explain the differences between these two regions. Methods This population-based study uses administrative databases from Belgian and Quebec birth records. The analysis is based on 97,844 and 214,620 singleton live births in Brussels and Montreal, respectively. Logistic regression models were developed for each region in order to estimate the relationship between SES (maternal education and income quintile) and pregnancy outcomes. The analyses were performed for all births according to the mother’s origin. Results SES is associated with LBW and preterm birth in both regions. This association varies according to the mother’s birth place; the impact of SES being greater for mothers born in Belgium or Canada than for those born abroad. The main difference between the two regions concerns the magnitude of perinatal inequalities, which is greater in Montreal than in Brussels, whether among the general population, native-born mothers, or immigrant mothers. Conclusion Significant differences in social inequalities in perinatal health are observed between Brussels and Montreal. The different characteristics of low-income and immigrant households between the two contexts help explain these results. In fact, the poor are relatively poorer in Quebec than in Belgium and live in a more unequal context.
The Influence of Prior Abdominal Surgery on Robot-Assisted Partial Nephrectomy
Authors: Yumioka Tetsuya , Honda Masashi , Teraoka Shogo , Kimura Yusuke , Iwamoto Hideto , Morizane Shuichi , Hikita Katsuya , Takenaka Atsushi 
Published: March 2021

Abstract
Background: The aim of this study was to evaluate the influence of prior abdominal surgery on perioperative outcomes in patients who underwent robot-assisted partial nephrectomy.Methods: We reviewed patients with small renal tumors who underwent robot-assisted partial nephrectomy from October 2011 to September 2020 at our institution. Comparisons between patients with prior abdominal surgery and with no prior abdominal surgery were based on perioperative outcomes. Furthermore, patients underwent transperitoneal robot-assisted partial nephrectomy was compared between those with and without prior abdominal surgery. The Mann–Whitney U test and the chi-square test were used for statistical analyses of variables. Results: Of 156 patients who underwent robot-assisted partial nephrectomy, 90 (58 %) had no prior abdominal surgery, whereas 66 patients (42 %) underwent prior abdominal surgery. No significant differences in perioperative outcomes were observed between with and without prior abdominal surgery groups. In transperitoneal approach robot-assisted partial nephrectomy, 31 patients (38.8 %) had prior abdominal surgery, whereas 49 patients had no prior abdominal surgery. Trocar insertion time in the with prior abdominal surgery group took longer than the without prior abdominal surgery group (32 vs. 28.5 min, p = 0.031). The other perioperative outcomes were no significant differences. In the conversion rate, no significant difference was observed between the two groups (p = 0.556).Conclusions: Prior abdominal surgery does not appear to affect Robot-assisted partial nephrectomy. Robot-assisted partial nephrectomy can be a safe procedure for patients with prior abdominal surgery. In transperitoneal approach robot-assisted partial nephrectomy with prior abdominal surgery, trocar insertion time was longer, but no significant differences were found in other outcomes. The conversions to radical nephrectomy and open partial nephrectomy were not associated with prior abdominal surgery. Transperitoneal approach robot-assisted partial nephrectomy is thus considered a safe procedure for patients with prior abdominal surgery.
A Functional Map of Genomic HIF1α-DNA Complexes in The Eye Lens Revealed Through Multiomics Analysis
Authors: Disatham Joshua , Brennan Lisa , Chauss Daniel , Kantorow Jason , Afzali Behdad , Kantorow Marc 
Published: March 2021

Abstract
Background: During eye lens development the fetal vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that parallels the natural differentiation of immature surface epithelial cells into mature core transparent fiber cells. These properties of the lens suggest a potential role for hypoxia in the regulation of genes required for mature lens structure and function. Since HIF1α is a master regulator of the hypoxic response, these lens properties also implicate HIF1α as a potential requirement for lens formation and homeostasis. Here, we employed a multiomics approach combining CUT&RUN, RNAseq and ATACseq analysis to establish the genomic complement of lens HIF1α binding sites, genes activated or repressed by HIF1α and the chromatin states of HIF1α-regulated genes.Results: CUT&RUN analysis revealed 8,375 HIF1α-DNA binding complexes in the chick lens genome. 1,190 HIF1α-DNA binding complexes were significantly clustered within chromatin accessible regions (χ2 test p < 1x10-55) identified by ATACseq. Formation of the identified HIF1α-DNA complexes paralleled the activation or repression of 526 genes, 116 of which contained HIF1α binding sites within 10kB of the transcription start sites. Some of the identified HIF1α genes have previously established lens functions while others have novel functions never before examined in the lens. GO and pathway analysis of these genes implicate HIF1α in the control of a wide-variety of cellular pathways potentially critical for lens formation, structure and function including glycolysis, cell cycle regulation, chromatin remodeling, Notch and Wnt signaling, differentiation, development, and transparency. Conclusions: These data establish the first functional map of genomic HIF1α-DNA complexes in the eye lens. They identify HIF1α as an important regulator of a wide-variety of genes previously shown to be critical for lens formation and function and they reveal a requirement for HIF1α in the regulation of a wide-variety of genes not yet examined for lens function. They support a requirement for HIF1α in lens development, structure and function and they provide a basis for understanding the potential roles and requirements for HIF1α in the development, structure and function of more complex tissues.
T2-weighted Magnetic Resonance Imaging as a novel predictor of surgical remission in newly diagnosed acromegaly
Authors: Akkaya Enes , Akgun Mehmet Yigit , Durmaz Emine Sebnem , Aydin Seckin , Ozkaya Hande Mefkure , Kizilkilic Osman , Gazioglu Nurperi , Kadioglu Pinar , Tanriover Necmettin 
Published: March 2021

Abstract
Background

Any preoperative diagnostic assessment that can predict the success of the operation in acromegaly will provide a positive impact on overall remission rates. The aim of this study is to present whether signal intensity on T2-weighted Magnetic Resonance Imaging could predict postoperative results in acromegaly patients.
Methods

We analyzed our surgical results in regard to T2-weighted images in newly diagnosed consecutive 124 patients with acromegaly, operated between 2014 and 2019. The T2-intensity of the pure somatotroph adenomas was correlated with the clinical, radiological, surgical and histopathological characteristics of the acromegaly patients.
Results

We found a predominance of T2-hyperintensity in our series (45%) and the T2-hypointense pure somatotroph adenomas were detected in only 34% of our patients. Total resection was performed in 72% of newly diagnosed acromegaly patients in this series. Accordingly, total resection was achieved in 69% of the T2-hyperintense group, 77% of the T2-hypointense group and 69% of the T2-isointense group. The surgical remission rates for the T2-hyper-, hypo- and isointense groups were 55%, 80%, and 69%, respectively. The surgical remission rate in the T2-hyperintense group was significantly lower than those of hypo- and isointense groups in newly diagnosed acromegaly patients.
Conclusions

This study demonstrates a close relationship between the T2 signal intensity and the surgical remission rates in acromegaly. T2 signal intensity seems to be an indicator of the degree of surgical resection completeness in pure somatotroph adenomas. The implications suggest that preoperative T2-intensity may directly predict the probability of post-surgical remission as an important independent factor in patients with newly diagnosed acromegaly.
Genetic Parameters of Water and Feed Intake and Behavior Traits of Wean-to-Finish Pigs Under a Polymicrobial Natural Disease Challenge
Authors: Cheng Jian , Putz Austin M. , Harding John C. S. , Dyck Michael K. , Fortin Frederic , Plastow Graham S. , Dekkers Jack 
Published: March 2021

Abstract
BackgroundThe pork industry faces unprecedented challenges from disease, which increases cost of production and use of antibiotics, and reduces production efficiency, carcass quality, and animal wellbeing. One solution is to improve the overall resilience of pigs to a broad array of common diseases through genetic selection. Behavioral changes in eating and drinking are usually the very first clinical signs when animals are exposed to stressors such as disease. Changes in feed and water intake behaviors in diseased pigs may reflect the way they cope with the challenge and, thus, could be used as indicator traits to selection of disease resilience. The objectives of this study were to estimate genetic parameters of feed and water intake and behavior traits for wean-to-finish pigs in a natural polymicrobial disease challenge model, estimate genetic correlations of feed and water intake and behavior traits with growth rate and clinical disease traits, and to develop indicator traits for selection of disease resilience.ResultsIn general, water intake traits had moderate to high estimates of heritability, especially for average daily water dispensed, duration, and number of visits (0.44 to 0.58). Similar estimates were observed for corresponding feed intake traits (0.35 to 0.51). Most genetic correlation estimates among drinking traits were moderate to high (0.30 to 0.92) and higher than among feeding traits (0 to 0.11). Compared to other water intake traits, water intake duration and number of visits had relatively stronger negative genetic correlation estimates with treatment rate and mortality, especially across the challenge nursery and finisher (-0.39 and -0.45 for treatment rate; -0.20 and -0.19 for mortality). Conclusion﻿Most water and feed intake traits under severe disease challenge had moderate to high estimates of heritability, especially for feed or water intake duration and number of visits. Phenotypic and genetic correlations among feed intake traits under disease were generally low but water intake traits showed high correlations with each other. Water intake duration and number of visits are potential indicator traits to select for disease resilience because of their high heritability and had moderate genetic correlations with treatment and mortality rates under severe disease.