bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric effects of Indian Ocean dipole on surface chlorophyll variability in the Indian Ocean
Authors: Abeywickrama Thivin , Pathirana Gayan , Noh Kyung-Min , Dissanayake Kushlani , Wang Dongxiao , Lee Dong-Geon 
Published: December 2024

Abstract

The Indian Ocean Dipole (IOD) is a dominant climate mode in the Indian Ocean, characterized by oscillating sea surface temperature anomalies between the western and southeastern equatorial regions. The IOD influences surface circulation, affecting coastal upwelling (downwelling), thereby increasing (decreasing) surface nutrients. These changes alter surface phytoplankton populations, measurable through their photosynthetic pigment, chlorophyll-a. The positive (pIOD) and negative (nIOD) phases of the IOD affect surface chlorophyll differently, particularly along the west of Sumatra (WS) and southwest of the Indian subcontinent (SWI). While changes in surface chlorophyll occur oppositely during each IOD phase, it is unclear how the intensity of surface chlorophyll changes during the positive and negative IOD phases. Given its importance, we investigate this question using observational data and historical simulations from a Coupled Model Intercomparison Project Phase 6 (CMIP6) model. Our findings reveal that although the chlorophyll response follows a dipole pattern, the pIOD phase exerts a dominant influence, with chlorophyll intensity during pIOD exceeding that during nIOD. Specifically, during pIOD, chlorophyll concentrations increase in the WS region and decrease in the SWI region, showing pronounced asymmetry in the intensity of IOD-induced chlorophyll changes. This disparity is driven by anomalous southeasterly winds during pIOD, which enhance nutrient upwelling in the WS and suppress it in the SWI, leading to variations in surface chlorophyll blooms. Thus, our results emphasize the asymmetric nature of IOD-induced changes in surface chlorophyll in the Indian Ocean, with important implications for marine food webs, fisheries, ocean biogeochemical cycles, and global climate systems.
MSU-Mamba: Multi-Scale Defocus Blur Detection Using Cross-Scale Fusion and State Space Models
Authors: Wang Xijun , Zhou Xin , Wang Yi , Zeng Songto , Liu Xinyu , Shen Haobo , Fei Song , Zhu Lei 
Published: December 2024

Abstract

Defocus blur detection (DBD) plays a pivotal role in computer vision, serving as a fundamental step to enhance the performance of various downstream applications, such as image refocusing, depth estimation, and saliency detection. Despite recent advancements, existing methods often struggle in complex scenes with homogeneous regions, subtle blur transitions, and cluttered backgrounds. In this paper, we develop a novel approach (MSU-Mamba) to combine a multi-scale feature extraction with state-space modeling for boosting defocus blur detection. To do so, we develop a Multi-Scale Fusion (MSF) Block to integrate long-range dependency features across multiple scales to enhance feature representation. Moreover, in our MSF block, we devise a cross-scale token scanning mechanism into the original Mamba to better distinguish blurred and sharp regions. Comprehensive experiments conducted on benchmark datasets show that our MSU-Mamba outperforms state-of-the-art methods in terms of F-measure and MAE. The results validate our approach as a promising solution to the challenges of defocus blur detection and its application to downstream tasks.
Antibiotic resistance in Pseudomonas aeruginosa: A systematic review of prevalence, patterns, and public health implications in Bangladesh (2006–2024)
Authors: Tayef Md. Sheikh , Sikder Rushafi , Shahiuzza Munsi Md , Hossain Md. Sazzad , Sikder Mashfi , Shaon Md. Akeruzzaman 
Published: December 2024

Abstract

Antimicrobial resistance (AMR) poses a critical global public health threat, with Pseudomonas aeruginosa emerging as a formidable MDR pathogen. This systematic review examines the prevalence and patterns of antibiotic resistance in P. aeruginosa within Bangladesh from 2006 to 2024. A comprehensive literature search was conducted across databases including PubMed, Google Scholar, Science.gov, and ResearchGate, yielding 12 studies that met the inclusion criteria. Most of these studies were conducted in Dhaka between 2021 and 2024, utilizing the disk diffusion method following CLSI guidelines. Findings indicate alarmingly high resistance rates to several commonly used antibiotics, including vancomycin (100%), cefoxitin (100%), amoxicillin (96.37%), erythromycin (95.48%), and ampicillin (91.43%). Notably, lower resistance was observed for colistin (19.05%) and piperacillin/tazobactam (28.70%), suggesting these antibiotics remain viable treatment options. The resistance mechanisms of P. aeruginosa, such as low outer membrane permeability, active efflux pumps, and biofilm formation, contribute to its resilience against antimicrobial agents. Comparative analysis reveals that resistance rates in Bangladesh are significantly higher than those reported in other regions, exacerbating the challenge of managing infections effectively. This review recommends implementing nationwide surveillance systems, stringent antimicrobial stewardship programs, and enhanced infection control measures to address the escalating AMR crisis. Furthermore, there is an urgent need for research into novel therapeutic strategies and the development of new antibiotics. By synthesizing current evidence, this study aims to inform policymakers, guide clinical practices, and support public health initiatives to mitigate the impact of antibiotic-resistant P. aeruginosa in Bangladesh.
Lunar satellite analytic theory with complete gravity and third-body perturbations Part-I: Gravity harmonics and their coupling effects
Authors: Mahajan Bharat 
Published: December 2024

Abstract

Artificial satellite theories for the Moon differ in important aspects from the similar theories for Earth because of more uneven nature of lunar gravity, strong third-body perturbations, and no atmospheric drag. The existing lunar satellite theories include only a few gravity spherical harmonics along with Hill’s approximation of the third-body disturbing function. Despite such simplifications, they provide semi-analytical solutions and require numerical propagation, thus limiting their applications. In this work, a fully analytic theory for lunar satellites is developed using generalized formulae that enable inclusion of spherical harmonics up to an arbitrary degree and order. The complete gravity and third-body disturbing functions are together considered as the dominant perturbation to the Keplerian Hamiltonian, which is then fully normalized up to second order by constructing three canonical transformations for averaging out the short-, medium-, and long-period terms. The gravity harmonics are fully treated in Part-I of this paper with the short- and medium-period terms developed up to first order and the long-period and secular terms up to second order. These second-order terms capture the coupling effects of the gravity harmonics. For the third-body perturbation, the secular terms are developed up to first order here. The periodic effects (including those originating from the coupling of gravity and third-body terms) will be explicitly treated in Part-II of this paper. The significance of the coupling effects from the gravity harmonics is assessed by comparing the analytically-propagated ephemerides of low-altitude lunar satellites with the numerically-propagated results.
Discovery of an Earthborn quasicrystal approximant
Authors: Bindi Luca , Cabri Louis J. , Mihalkovič Marek , Laufek Frantisek , Krivovichev Sergey V. 
Published: December 2024

Abstract
Natural quasicrystals, compounds with characteristics intermediate between crystalline material and glass, have been so far discovered in extraterrestrial materials only. Further, their occurrence in nature is limited to metallic, Al-bearing alloys. The presence of metallic aluminum in these minerals raised doubts about their potential occurrence in terrestrial rocks. The geochemical conditions needed to form metallic Al are so reducing that they are considered very unlikely in a terrestrial environment. Given the report of dodecagonal symmetry in the synthetic Ta1.6Te quasicrystal, the search for terrestrial quasicrystals was focused on natural tellurides. Here, we report the discovery of the first terrestrial approximant of a dodecagonal quasicrystal, a Pd-Ni-telluride with formula Pd3Ni4Te8 and tetragonal symmetry, which was found as small inclusions in a rock sample coming from Kalgoorlie, Western Australia. Periodic approximants are crystalline materials that share a similar chemical composition with quasicrystals but have a slightly altered atomic structure, aligning their symmetry with the traditional principles of three dimensional crystallography. These crystalline approximants provide insights into the local atomic structure of their corresponding quasicrystals.
Natural Pd3Ni4Te8 has been approved as a new mineral by the International Mineralogical Association with the name proxitwelvefoldite (IMA 2024-034). The Pd3Ni4Te8 composition has also been never reported to form quasicrystal approximants among synthetic products and could indicate the possible existence of a 12-fold quasicrystal in the Pd-Ni-Te system. The discovery points to the possibility that the quasicrystalline structure may be much more common than previously thought, even in non-alloy systems.
Effect of Biomedical Hydrogels on Exercise-induced Muscle Damage: A Narrative Review
Authors: Cai Jie , Fan Mingbo , Yu Ailin , Wu Chenghu 
Published: December 2024

Abstract:
Exercise-induced muscle damage (EIMD) is a common occurrence among
athletes and individuals engaged in physical fitness activities. Muscle strains result from
excessive or repetitive muscle tension, leading to tissue damage, inflammation, and
pain. These strains can range from mild discomfort to severe damage, resulting in pain,
inflammation, and reduced functionality. Effective management of muscle damage is
crucial for promoting recovery and returning individuals to their desired level of activity.
Conventional treatment modalities such as rest, ice, compression, and elevation
(RICE), physical therapy, and nonsteroidal anti-inflammatory drugs (NSAIDs) have limitations
in terms of efficacy and long-term outcomes. Consequently, there is a need for innovative
approaches that not only address the symptoms but also promote healing and
prevention of future injuries. Hydrogels are three-dimensional crosslinked networks of
hydrophilic polymers that have gained significant attention in the field of biomedicine.
Their unique properties, drug-delivery capabilities, and capacity to provide mechanical
support make them promising tools in muscle damage management. Biomedical hydrogels
hold significant potential as a preventive or alleviative approach for EIMD. This review
provides a comprehensive overview of biomedical hydrogels as a promising approach
for preventing and alleviating EIMD, addressing current challenges, and outlining
future directions for research and development in the field.
Malignant Brain Edema and Associated Factors in Large Hemispheric
Infarction Following Reperfusion Therapy
Authors: Li Jie , Tao Wendan , Wang Deren , Liu Junfeng , Liu Ming 
Published: December 2024

Objective:
This study aimed to explore Malignant Brain Edema (MBE) and associated
factors in patients with Large Hemispheric Infarction (LHI) following early reperfusion therapy.

Methods:
We consecutively and retrospectively enrolled a cohort of 114 LHI patients who had received
early reperfusion therapy, including Intravenous Thrombolysis (IVT) or Endovascular Therapy
(EVT) at the hyperacute stage of stroke between January 2009 and December 2018. MBE was
defined as a midline shift ≥5 mm, accompanied by signs of herniation. Multivariate logistic analyses
were conducted to identify independent factors associated with MBE in LHI patients following
early reperfusion therapy.

Results:
Among the enrolled patients, 69 (60.53%) were treated with IVT alone and 45 (39.47%)
with EVT. Successful recanalization was achieved in 56 (49.12%) patients, while complete recanalization
was achieved in 38 (33.33%) patients. After early reperfusion therapy, 50 (43.86%) developed
MBE in LHI patients. The MBE group showed higher rates of in-hospital death (54% vs.
4.69%), 3-month mortality (64% vs. 10.94%), and 3-month unfavorable outcomes (90% vs.
64.06%) (all p<0.01). Neither different reperfusion therapy (EVT vs. IVT alone) nor different recanalization
status (complete recanalization or not) was independently associated with the development
of MBE in LHI patients following reperfusion therapy in multivariate analyses. MBE was independently
associated with age [Odds Ratio (OR) 0.953, 95% confidence interval (CI)
0.910-0.999, p =0.044], right hemisphere stroke (OR 4.051, 95% CI 1.035-15.860, p =0.045), previous
ischemic stroke or TIA (OR 0.090, 95% CI 0.014-0.571, p =0.011), and hypodensity >1/3
MCA territory (OR 8.071, 95% CI 1.878-34.693, p =0.005). Meanwhile, patients with lower baseline
Alberta Stroke Program Early CT Score (ASPECTS) had a trend of higher incidence of MBE
following reperfusion therapy (OR 0.710, 95% CI 0.483-1.043, p =0.081).

Conclusion:
MBE occurred in nearly one-half of LHI patients following early reperfusion therapy
and was related to poor outcomes. An increased risk of MBE was found to be associated with
younger age, right hemisphere stroke, absence of a history of ischemic stroke or TIA, and hypodensity
>1/3 MCA region on baseline CT images.
Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer’s Disease
Authors: Verma Mansi , Usman MS Mohd , Singh Niraj Kumar 
Published: December 2024

Abstract:
Alzheimer’s Disease (AD), a prevalent neurodegenerative disorder, poses a significant
global health challenge with complicated pathogenesis. Pathological characteristics of AD include
increasing loss of cholinergic neurons, oxidative stress, mitochondrial dysfunction, and amyloid
beta accumulation. Due to the limited availability of effective therapeutic options with only symptomatic
relief and their severe adverse effects, there is a significant need to search and explore new
agents for the management of AD. Recently, natural products and/or phytoconstituents of plants
have gained notable attention as potential sources of neuroprotective agents due to their diverse
chemical constituents, mechanism of action, and relatively safe profiles. In view of this, Glycyrrhiza
glabra has been recognized for its several therapeutic properties in traditional medicine systems
for centuries. Further, neuroactive phytoconstituents of this plant, including glycyrrhizin,
liquiritigenin, isoliquiritigenin, glabridin, and glycyrrhizic acid, exhibit significant pharmacological
advantages along with potential neuroprotective effects against AD. Glycyrrhiza glabra and its
phytoconstituents have gained significant interest due to its ability to exert a neuroprotective impact
by influencing multiple signaling pathways, inhibiting AChE and BACE1 activity, reducing
Aβ accumulation, plaque formation, and tau phosphorylation, and quenching the free radical in
experimentally-induced AD-like brain. The present review summarizes available in vitro and in
vivo preclinical studies that have been performed to evaluate the beneficial neuroprotective effect
of Glycyrrhiza glabra and its phytoconstituents against AD-like pathology. Based on available
facts, it can be concluded that neuroactive phytoconstituents of Glycyrrhiza glabra could be significant
lead molecules for the drug discovery of anti-AD medicines in the future.
Research Progress of Isoxazoline Insecticides
Authors: Song Hongjian , Li Yongqiang , Zhang Jingjing , Wang Ziwen , Liu Yuxiu , Wang Qingmin 
Published: December 2024

Abstract:
Isoxazoline insecticides constitute a class of compounds featuring the isoxazoline
structure, which primarily exert their effects by inhibiting the γ-aminobutyric acid (GABA)-
gated chloride channel in insects. GABA serves as the primary inhibitory neurotransmitter in
invertebrates, with its receptor composed of subunits encoded by the Rdl gene. By selectively
inhibiting the GABA-Cl receptor subunit in invertebrates, isoxazolines block inhibitory neurotransmission,
ultimately resulting in insect mortality. This unique mechanism of action endows
isoxazolines with a high degree of selective toxicity toward insects while maintaining
relative safety for mammals. Recently, isoxazoline insecticides have garnered considerable attention
due to their broad-spectrum efficacy, high potency, and environmentally friendly profile.
These compounds have emerged as promising solutions in crop protection and animal
health management, offering innovative means to combat insect pests and parasites. Their development
represents a significant advancement in pesticides, offering farmers and veterinarians
effective and sustainable options for managing agricultural and animal health challenges.
This review mainly introduces the current commercialized and under-development isoxazoline
insecticides, the research progress on the mechanism of action of isoxazoline insecticides,
the study of synthetic methods, as well as the research progress in structural derivation and
structure-activity relationship.
Must-Eat High Proteinous Plant Sources for Vegetarians: A Perspective
Authors: Kumari Sunita , Chaurasia Pankaj Kumar , Bharati Shashi Lata 
Published: December 2024

Objective:
The main objective of this perspective article is to briefly discuss the eight
inexpensive, protein-rich, highly nutritious plant sources as an alternative to animal proteins.

Methods:
The study is based on a literature search via Google Scholar, Research Gate, Scopus,
Web of Sciences, Pub-Med, etc.

Result and Conclusion:
Eight protein-rich plant sources like flaxseeds, chickpeas, soybeans,
green peas, kidney beans, peanuts, mung beans, and cowpeas have been presented briefly. In
addition to protein, they are also full of carbohydrates, minerals, vitamins, and several bioactive
molecules, indicating many biological applications in the solution of multiple health issues and
strongly promoting health. Thus, the addition of these nutritious plant sources in our daily diet
in mixed form fulfills the daily nutrient requirement and is very helpful in health promotion and
the fight against malnutrition.
Formulation, Characterization, and Cytotoxic Effect of Indomethacin-Loaded Nanoparticles
Authors: Yalçınkaya Kaan , Şenel Behiye , Akyıl Evrim 
Published: December 2024

Background:
Indomethacin (IND), classified as class 2 in the Biopharmaceutical Classification System (BCS), has emerged as an anti-inflammatory agent with low solubility and high permeability. Widely used in the treatment of various diseases, such as rheumatoid arthritis and ankylosing spondylitis, this drug is well-known for its adverse effects, particu-larly in the stomach, and a short biological half-life, which is around 1.5-2 hours.

Objective:
The aim of this study was to overcome the challenges of low solubility, short half-life, and serious side effects occurring with the use of IND-loaded formulations of Solid Lipid Nanoparticles (SLNs) and Polymeric Nanoparticles (PNPs).

Methods:
For PNPs, emulsification/solvent evoporation method was employed, and for SLNs, the hot homogenizaton method was applied. Eudragit® RLPO (RLPO) and Eudragit® RSPO (RSPO) were used as polymers for PNP and Dynasan®116 (DYN) was used as the solid lipid for SLN. Prepared formulations were characterized for Particle Size (PS), Poly-dispersity Index (PDI), Zeta Potential (ZP), Encapsulation Efficiency (%EE), and drug-ex-cipient compatibility using DSC, FT-IR, and 1H NMR; cumulative drug release rates were assessed using HPLC and in vitro cytotoxicities were examined by the MTT assay.

Results:
Both PNP and SLN formulations’ zeta potential, particle size, and PDI results in-dicated the formulations to have good stability. Encapsulation efficiency values were ob-tained as desired. Drug-excipient compatibility was proved using DSC, FT-IR, and 1H NMR. In vitro dissolution results have proven both formulations to have longer release than pure indomethacin. In the MTT analysis of indomethacin application for 24 and 48 hours, a linear correlation was observed between drug concentration and cell viability, and it was determined that the PNP formulation exhibited fewer toxic effects among the formulations. This has proven the PNP nanocarrier as safer for normal cells.

Conclusion:
IND-loaded PNP and SLN formulations have been successfully prepared in this work and they have achieved drug release in the intestine and prolonged the release duration.
Potential of Andrographolide and Andrographis paniculata Extracts for the Management of Diabetes-associated Psychopathologies: Current Status
Authors: Chatterjee Shyam Sunder , Rani Sweta , Sah Riya , Thakur Ajit Kumar 
Published: December 2024

Abstract:
Despite the availability of numerous anti-hyperglycemic and psychoactive drugs, and diverse
therapeutic modalities, prevention and cure of diabetes-associated mental health problems
continue to be a major challenge for medical practitioners. Considerable efforts have been made in
many research laboratories, including ours, to identify the bioactive of traditionally known medicinal
or food plants to identify their bioactive that could be used for the treatment of diabetes and
comorbidities in metabolic disorders. Andrographis paniculata (Burm. F.) Wall. Ex. Nees. has been
used in Ayurvedic and other traditionally known healthcare systems of India and many other Asian
countries. Due to its extremely bitter taste, it is often referred to as the “king of bitters” and commonly
known as “Kalmegh”. Andrographolide is one such metabolite of Andrographis paniculata
used in many Asiatic countries for the treatment of diverse age and lifestyle-associated chronic diseases
now used for discovering and developing anti-diabetic and other drugs. Available data on andrographolide
and Andrographis paniculata strongly recommend that they could be better therapeutic
choices for the prevention of diabetes and associated mental health problems than metformin and
other pharmacotherapeutics currently commercialized for such purposes. However, the question of
whether andrographolide or extracts of the plant enriched in it could be better suited for such purposes
remains open. Currently, available quantitative data on their anti-hyperglycemic effects and
brain function-modulating effects useful for answering this question are discussed in this report in
light of our current knowledge of the role of gut microbiota in regulating glucose homeostasis and
mental health. Their potential uses for discovering and developing drugs or phytotherapeutics from
them are also pointed out.