bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating integration in collaborative cross-disciplinary FDA new drug reviews using an input-process-output model
Authors: Bugin Kevin , Lotrecchiano Gaetano R. , O’Rourke Michael , Butler Joan 
Published: September 2021

Abstract

Background/Objectives:
The US Food and Drug Administration (FDA) is responsible for assessing safety (risks) and effectiveness (benefits) of new drug products using the data provided in a Sponsor’s new drug product marketing application before they can be marketed. The FDA forms cross-disciplinary review teams to conduct these assessments. Recently, the FDA began implementing more interdisciplinary approaches to its assessments, reducing redundancy in review processes and documentation by increasing team integration around review issues.

Methods:
Through a phenomenological descriptive comparative case study, the impact of FDA’s new interdisciplinary approach on review team integration was compared with its traditional multidisciplinary review approach.

Results:
We identified collaborative integration occurring in one FDA review team using the new interdisciplinary review and another team using the traditional review and then modeled and analyzed the collaborative, cross-disciplinary integration in each case using an input-process-output (IPO) model drawn from the Science-of-Team-Science (SciTS).

Conclusion:
This study provides a systematic method for understanding and visualizing integration in each type of review previously and presently used at FDA and illustrates how the new interdisciplinary approach can ensure more integration than more traditional approaches previously used. In addition, our study suggests that an IPO model of integration can characterize how effectively FDA review teams are integrating around issues and assist in the evaluation of differences in integration between FDA’s new interdisciplinary review and the existing multidisciplinary approach. The approach used here is a new application of SciTS scholarship in a unique sector, and it also serves as an example for measuring review team effectiveness.
CATEGORIZING LABORERS: GLIMPSES OF QIN MANAGEMENT OF HUMAN RESOURCES FROM AN ADMINISTRATIVE DOCUMENT FROM LIYE, HUNAN PROVINCE
Authors: Ma Tsang Wing 
Published: September 2021

AbstractThe excavation of the Qin wooden documents from Well No. 1 at Liye 里耶, Hunan province has significantly reshaped our knowledge of Qin history. This article examines a multi-slip manuscript from Liye on the Qin management of human resources in a newly conquered area, Qianling County. The manuscript is the best example of the multi-layered structure of a Qin administrative document; it also sheds new light on the difficulties the Qin encountered in resource management during the early years of unification. The manuscript shows that the responsible officials in Qianling County had failed to engage tuli 徒隸 (laborer-servants)—a major labor source in the Qin—in agricultural production, which appears to have deviated from the Qin strategy of managing human resources. To minimize the harmfulness that this deviation might cause, the Qin heavily relied upon a system of supervision and punishment. This article offers a contextualized study of the manuscript with an analysis of the related Qin excavated sources.
RECENTLY EXCAVATED INSCRIPTIONS AND MANUSCRIPTS (2008–2018)
Authors: Venture Olivier 
Published: September 2021

AbstractBetween 2008 and 2018 a significant number of inscriptions and manuscripts from early China were discovered or published. These sources include hundreds of new oracle bone and bronze inscriptions; more than thirty scientifically excavated literary manuscripts; thousands of private and official scientifically excavated documents; and more than seventy literary texts acquired from the antiquities market. This review article, focusing mainly on artifacts with archaeological provenance, offers a global overview of these new materials that have already renewed, or will certainly soon renew, the field of early China studies.
Music and dance are two parallel routes for creating social cohesion
Authors: Brown Steven 
Published: September 2021

Abstract
Savage et al. do an excellent job of making the case for social bonding in general, but do a less good job of distinguishing the manners by which dance and music achieve this. It is important to see dance and music as two parallel and interactive mechanisms that employ the “group body” and “group voice,” respectively, in engendering social cohesion.
Music production deficits and social bonding: The case of poor-pitch singing
Authors: Pfordresher Peter Q. 
Published: September 2021

Abstract
Both of the companion target articles place considerable performance on music performance ability, with specific attention paid to singing in harmony for the music and social bonding (MSB) hypothesis proposed by Savage and colleagues. In this commentary, I evaluate results from recent research on singing accuracy in light of their implications for the MSB hypothesis.
Rapid dissonant grunting, or, but why does music sound the way it does?
Authors: Sievers Beau R. , Wheatley Thalia 
Published: September 2021

Abstract
Each target article contributes important proto-musical building blocks that constrain music as-we-know-it. However, neither the credible signaling nor social bonding accounts elucidate the central mystery of why music sounds the way it does. Getting there requires working out how proto-musical building blocks combine and interact to create the complex, rich, and affecting music humans create and enjoy.
Human evolution of gestural messaging and its critical role in the human development of music
Authors: Gardiner Martin F. 
Published: September 2021

Abstract
By fostering bonding (Mehr et al.; Savage et al.), music illustrates marvelously its ability to induce emotional experience. But, music can induce emotion more generally as well. To help explain how music fosters bonding and induces other emotions, I propose that music derives this power from the evolution of what I term “gestural messaging.”
A boldly comparative approach will strengthen co-evolutionary accounts of musicality's origins
Authors: Rendell Luke , Doolittle Emily L. , Garland Ellen C. , South Alex 
Published: September 2021

Abstract
Focus on the evolutionary origins of musicality has been neglected relative to attention on language, so these new proposals are welcome stimulants. We argue for a broad comparative approach to understanding how the elements of musicality evolved, and against the use of overly simplistic evolutionary accounts.
Music's putative adaptive function hinges on a combination of distinct mechanisms
Authors: Gingras Bruno 
Published: September 2021

Abstract
Music's efficacy as a credible signal and/or as a tool for social bonding piggybacks on a diverse set of biological and cognitive processes, implying different proximate mechanisms. It is likely this multiplicity of mechanisms that explains why it is so difficult to account for music's putative biological role(s), as well as its possible origins, by proposing a single adaptive function.
Toward a productive evolutionary understanding of music
Authors: Mehr Samuel A. , Krasnow Max M. , Bryant Gregory A. , Hagen Edward H. 
Published: September 2021

AbstractWe discuss approaches to the study of the evolution of music (sect. R1); challenges to each of the two theories of the origins of music presented in the companion target articles (sect. R2); future directions for testing them (sect. R3); and priorities for better understanding the nature of music (sect. R4).
How not to answer interdisciplinary “Why?” questions
Authors: Bookstein Fred L. 
Published: September 2021

Abstract
The book under review tries to link the economic concept of “reward,” or, more accurately, “capture rate,” to the experimental literature of various neuroscientific quantities dealing with motor control. But this reviewer argues that such a linkage requires a richer language of quantification than the book actually affords: a language not just of “greater” or “less,” but of how much greater or less. Without such a methodology, the arguments here cannot be persuasive.
The relationship between mitochondrial ND5 gene polymorphisms and in vitro embryo production in Sanjabi sheep
Authors: Teymouri Fereshteh , Foroutanifar Saheb , Abdolmohammadi Alireza , Hajarian Hadi 
Published: September 2021

AbstractThe aim of this study was to investigate mitochondrial ND5 gene polymorphisms and their relationship with in vitro maturation (IVM) and in vitro culture (IVC) of Sanjabi sheep. Blood and ovarian samples of adult ewes were obtained from a local slaughterhouse. For each ovarian sample, cumulus–oocyte complexes larger than 3 mm in diameter were aspirated from follicles, and their IVM and IVC rates were recorded. A 666-bp fragment of the ND5 gene was amplified using the polymerase chain reaction. The samples were genotyped using a modified single-stranded conformation polymorphism (SSCP) method, and an association study was conducted with IVM and IVC rates. Six different SSCP patterns, designated A, B, C, D, E and F with respective frequencies of 8, 47, 4, 4, 32 and 5%, respectively, were observed. According to the results of association analysis, there was no significant association between the ND1 gene polymorphisms and the IVM and IVC rates (P > 0.05).
Topographic Roughness on Forested Hillslopes: A Theoretical Approach for Quantifying Hillslope Sediment Flux From Tree Throw
Authors: Doane Tyler H. , Edmonds Douglas , Yanites Brian J. , Lewis Quinn 
Published: September 2021

AbstractWind‐driven tree throw is an observable and consequential process that suddenly moves soil downslope, inverts the soil column, and roughens the surface with pit‐mound topography. Quantifying fluxes due to tree throw is complicated by its stochastic nature and estimation requires averaging over a large area or long time. Here, we develop a theory that leads to a dimensionless metric directly measurable from high resolution topographic data. The theory explains the flux and topographic roughness as a function of tree throw production and decay rate by creep‐like processes. We then form a measurable dimensionless variable that is the ratio of fluxes due to tree throw versus creep‐like processes. Applying the theory to hillslopes in Southern Indiana, we find that tree throw accounts for 11%–18% of the hillslope sediment flux. The theoretical and observational findings provide important constraints on quantifying Critical Zone function from topographic parameters such as roughness.
ULF Waves Observed by Lunar Prospector
Authors: Baek Seul‐Min , Kim Khan‐Hyuk , Seough Jungjoon , Choi Young‐Jun , Jin Ho 
Published: September 2021

AbstractWe have studied the spatial distribution of ultra‐low frequency (ULF) in the vicinity of the Moon using Lunar Prospector (LP) magnetometer data obtained at ∼100 km altitude during the period from February 20, 1998 to November 30, 1998. The lunar ULF waves are mostly identified over a broad frequency range of 10–60 mHz in the spacecraft frame. The occurrence rate of the ULF wave is high on the dayside above strong magnetic anomalies and depends on the interplanetary magnetic field orientation. We examine wave properties including the wave propagation direction and polarization. They are very similar to Kaguya observations, indicating that the ULF waves observed at LP and Kaguya are generated by the same mechanism. Although lunar ULF waves are commonly observed on the dayside above lunar magnetic anomalies, how they are established as a regular oscillation is not completely understood. In the present study, we suggest that the electromagnetic ion beam instability, driven by protons reflected from lunar magnetic anomalies, is the likely source of ULF waves observed at LP.
Defining the Coseismic Phase of the Crustal Deformation Cycle With Seismogeodesy
Authors: Golriz Dorian , Bock Yehuda , Xu Xiaohua 
Published: September 2021

AbstractEarth's crustal deformation cycle is traditionally divided into coseismic, postseismic, and interseismic phases upon which transient motions from various sources may be superimposed. Here we present a new seismogeodetic methodology to define and identify the transition from the coseismic to the early postseismic phase. While this early period of postseismic deformation has not been well observed, it plays an important role in better understanding fault processes and crustal rheology because it is where the fastest evolution of fault slip occurs. Current methods often choose to rely on geodetic displacements with several hour to daily resolution to estimate static coseismic offsets. The choice of data span is often arbitrary and introduces some fraction of postseismic motion. Instead, we apply a more physics‐based approach that is applicable to interleaved regional networks of high‐rate Global Navigation Satellite System (GNSS) and seismic sensors. The start time of the coseismic phase is based on P wave arrivals and its end time on the total release of energy derived from seismic velocities integrated from strong‐motion accelerations. In the absence of physical collocations, we interpolate the coseismic time window to the GNSS stations and estimate the static offsets from the high‐rate displacements. We demonstrate our methodology by applying it to 10 earthquakes over a range of magnitudes and fault mechanisms. We observe that the presence of early postseismic motions within the widely used estimates of daily coseismic offsets can lead to an overprediction of coseismic moment and fault slip, up to several meters depending on the magnitude and mechanism of the event.
Handling of targeted amplicon sequencing data focusing on index hopping and demultiplexing using a nested metabarcoding approach in ecology
Authors: Guenay-Greunke Yasemin , Bohan David A. , Traugott Michael , Wallinger Corinna 
Published: September 2021

AbstractHigh-throughput sequencing platforms are increasingly being used for targeted amplicon sequencing because they enable cost-effective sequencing of large sample sets. For meaningful interpretation of targeted amplicon sequencing data and comparison between studies, it is critical that bioinformatic analyses do not introduce artefacts and rely on detailed protocols to ensure that all methods are properly performed and documented. The analysis of large sample sets and the use of predefined indexes create challenges, such as adjusting the sequencing depth across samples and taking sequencing errors or index hopping into account. However, the potential biases these factors introduce to high-throughput amplicon sequencing data sets and how they may be overcome have rarely been addressed. On the example of a nested metabarcoding analysis of 1920 carabid beetle regurgitates to assess plant feeding, we investigated: (i) the variation in sequencing depth of individually tagged samples and the effect of library preparation on the data output; (ii) the influence of sequencing errors within index regions and its consequences for demultiplexing; and (iii) the effect of index hopping. Our results demonstrate that despite library quantification, large variation in read counts and sequencing depth occurred among samples and that the sequencing error rate in bioinformatic software is essential for accurate adapter/primer trimming and demultiplexing. Moreover, setting an index hopping threshold to avoid incorrect assignment of samples is highly recommended.
Designs for a two-dimensional Si quantum dot array with spin qubit addressability
Authors: Tadokoro Masahiro , Nakajima Takashi , Kobayashi Takashi , Takeda Kenta , Noiri Akito , Tomari Kaito , Yoneda Jun , Tarucha Seigo , Kodera Tetsuo 
Published: September 2021

AbstractElectron spins in Si are an attractive platform for quantum computation, backed with their scalability and fast, high-fidelity quantum logic gates. Despite the importance of two-dimensional integration with efficient connectivity between qubits for medium- to large-scale quantum computation, however, a practical device design that guarantees qubit addressability is yet to be seen. Here, we propose a practical 3 × 3 quantum dot device design and a larger-scale design as a longer-term target. The design goal is to realize qubit connectivity to the four nearest neighbors while ensuring addressability. We show that a 3 × 3 quantum dot array can execute four-qubit Grover’s algorithm more efficiently than the one-dimensional counterpart. To scale up the two-dimensional array beyond 3 × 3, we propose a novel structure with ferromagnetic gate electrodes. Our results showcase the possibility of medium-sized quantum processors in Si with fast quantum logic gates and long coherence times.
Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening
Authors: Work Hannah M. , Kandel Sylvie E. , Lampe Jed N. 
Published: September 2021

AbstractCYP3A7 is a member of the cytochrome P450 (CYP) 3A enzyme sub-family that is expressed in the fetus and neonate. In addition to its role metabolizing retinoic acid and the endogenous steroid dehydroepiandrosterone sulfate (DHEA-S), it also has a critical function in drug metabolism and disposition during the first few weeks of life. Despite this, it is generally ignored in the preclinical testing of new drug candidates. This increases the risk for drug-drug interactions (DDI) and toxicities occurring in the neonate. Therefore, screening drug candidates for CYP3A7 inhibition is essential to identify chemical entities with potential toxicity risks for neonates. Currently, there is no efficient high-throughput screening (HTS) assay to assess CYP3A7 inhibition. Here, we report our testing of various fluorescent probes to assess CYP3A7 activity in a high-throughput manner. We determined that the fluorescent compound dibenzylfluorescein (DBF) is superior to other compounds in meeting the criteria considered for an efficient HTS assay. Furthermore, a preliminary screen of an HIV/HCV antiviral drug mini-library demonstrated the utility of DBF in a HTS assay system. We anticipate that this tool will be of great benefit in screening drugs that may be used in the neonatal population in the future.
The Upper Triassic deposits of the west Bangong-Nujiang suture zone and their paleogeographic implications
Authors: Wu Guichun , Ji Zhansheng , Lash Gary G. , Yao Jianxin 
Published: September 2021

AbstractThe Bangong-Nujiang Suture Zone (BNSZ) of Tibet (Xizang) has been interpreted to represent a relic of the Bangong-Nujiang Ocean. However, the existence of this ocean during Triassic time remains a point of contention. A sedimentary succession spanning the Upper Permian through Triassic described from the central BNSZ suggests that the Lhasa and South Qiangtang terranes were contiguous thus negating the existence of a terrane-separating ocean during Triassic time. However, the apparent lack of Triassic deposits in the west BNSZ has called into question the existence of Triassic deposits in the central region of the BNSZ. Our biostratigraphic work in the Wuga Formation of the Gaize area has yielded abundant Norian conodonts thus confirming the existence of Upper Triassic deposits in the west BNSZ. The clastic deposits of the Wuga Formation are herein interpreted to be of Rhaetian age. Moreover, intercalated limestone and chert are termed the Dongnale Formation of Norian age. The Norian to Rhaetian succession can be correlated with strata of the central BNSZ as well as with deposits of the Lhasa Terrane and the South Qiangtang Terrane. Similar stratigraphies among these regions through the Late Triassic suggests a shared depositional setting and that the BNSZ was not an ocean in Norian and Rhaetian time.
Tracking forest loss and fragmentation between 1930 and 2020 in Asian elephant (Elephas maximus) range in Nepal
Authors: Ram Ashok Kumar , Yadav Nabin Kumar , Kandel Pem Narayan , Mondol Samrat , Pandav Bivash , Natarajan Lakshminarayanan , Subedi Naresh , Naha Dipanjan , Reddy C. Sudhakar , Lamichhane Babu Ram 
Published: September 2021

AbstractForest cover is the primary determinant of elephant distribution, thus, understanding forest loss and fragmentation is crucial for elephant conservation. We assessed deforestation and patterns of forest fragmentation between 1930 and 2020 in Chure Terai Madhesh Lanscape (CTML) which covers the entire elephant range in Nepal. Forest cover maps and fragmentation matrices were generated using multi-source data (Topographic maps and Landsat satellite images of 1930, 1975, 2000, and 2020) and spatiotemporal change was quantified. At present, 19,069 km2 forest cover in CTML is available as the elephant habitat in Nepal. Overall, 21.5% of elephant habitat was lost between 1930 and 2020, with a larger (12.3%) forest cover loss between 1930 and 1975. Area of the large forests (Core 3) has decreased by 43.08% whereas smaller patches (Core 2, Core 1, edge and patch forests) has increased multifold between 1930 and 2020. The continued habitat loss and fragmentation probably fragmented elephant populations during the last century and made them insular with long-term ramifications for elephant conservation and human-elephant conflict. Given the substantial loss in forest cover and high levels of fragmentation, improving the resilience of elephant populations in Nepal would urgently require habitat and corridor restoration to enable the movement of elephants.
Effect of host switching simulation on the fitness of the gregarious parasitoid Anaphes flavipes from a novel two-generation approach
Authors: Samková Alena , Raška Jan , Hadrava Jiří , Skuhrovec Jiří 
Published: September 2021

AbstractHerbivorous insects can escape the strong pressure of parasitoids by switching to feeding on new host plants. Parasitoids can adapt to this change but at the cost of changing their preferences and performance. For gregarious parasitoids, fitness changes are not always observable in the F1 generation but only in the F2 generation. Here, with the model species and gregarious parasitoid Anaphes flavipes, we examined fitness changes in the F1 generation under pressure from the simulation of host switching, and by a new two-generation approach, we determined the impact of these changes on fitness in the F2 generation. We showed that the parasitoid preference for host plants depends on hatched or oviposited learning in relation to the possibility of parasitoid decisions between different host plants. Interestingly, we showed that after simulation of parasitoids following host switching, in the new environment of a fictitious host plant, parasitoids reduced the fictitious host. At the same time, parasitoids also reduced fertility because in fictitious hosts, they are not able to complete larval development. However, from a two-generation approach, the distribution of parasitoid offspring into both native and fictitious hosts caused lower parasitoid clutch size in native hosts and higher individual offspring fertility in the F2 generation.