bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Tolerability of Lacosamide in Patients With Epilepsy: A Systematic Review and Meta-Analysis
Authors: Yang Chunsong , Peng Yuxuan , Zhang Lingli , Zhao Li 
Published: September 2021

Background: As a third-generation antiseizure medication (ASM), lacosamide (LCM) is recommended worldwide for patients with epilepsy. We aimed to provide more conclusive evidence for the safety and tolerability of LCM in patients with epilepsy.Methods: A systematic search was performed on MEDLINE, Embase, Cochrane Library, CBM, CNKI, IDB, VIP Database, and Wanfang Database from inception to 2021 March, and all studies assessing the safety of LCM were included. A meta-analysis was performed for safety data of LCM.Results: Eighty-three studies involving 12268 populations (11 randomized clinical trials (RCTs), 16 cohort studies, 53 case series, and 3 case reports) were included in our study. Meta-analysis of the total incidence of adverse events (AEs) of LCM was 38.7% [95% CI (35.1%, 45.8%); n=75 studies]. Incidence of withdrawal due to AEs was 10.8% [95% CI (9.1%, 12.6%); n=56 studies], and incidence of serious adverse events (SAEs) was 6.5% [95% CI (4.0%, 8.9%); n=13 studies]. Most AEs were in the nervous system and digestive system. The most common AEs were sedation (15.8%), dizziness (15.7%), fatigue (9.4%), and nausea/vomiting (9.3%). For children, the total incidence of AEs of LCM was 32.8% [95% CI (21.6%, 44.0%); n=16 studies], and the most common AEs were dizziness (8.6%), nausea/vomiting (8.6%), and somnolence (6.8%).Conclusion: Lacosamide is generally safe and well tolerated in patients with epilepsy. Common AEs were sedation, dizziness, and fatigue. It is necessary to pay more attention to the prevention and management of these AEs and conduct more large-scale and high-quality studies to update safety data.
Mediators and Theories of Change in Psychotherapy for Young People With Personality Disorders: A Systematic Review Protocol
Authors: Volkert Jana , Taubner Svenja , Barkauskiene Rasa , Mestre Jose M. , Sales Célia M. D. , Thiele Vanessa , Saliba Andrea , Protić Sonja , Adler Asta , Conejo-Cerón Sonia , Di Giacomo Dina , Ioannou Yianna , Moreno-Peral Patricia , Vieira Filipa Mucha , Mota Catarina Pinheiro , Raleva Marija , Rangel Santos Henriques Margarida Isabel , Røssberg Jan Ivar , Schmidt Stefanie J. , Perdih Tjasa Stepisnik , Ulberg Randi , Heinonen Erkki 
Published: September 2021

Background: Personality disorders (PDs) are a severe health issue already prevalent among adolescents and young adults. Early detection and intervention offer the opportunity to reduce disease burden and chronicity of symptoms and to enhance long-term functional outcomes. While psychological treatments for PDs have been shown to be effective for young people, the mediators and specific change mechanisms of treatment are still unclear.Aim: As part of the “European Network of Individualized Psychotherapy Treatment of Young People with Mental Disorders” (TREATme), funded by the European Cooperation in Science and Technology (COST), we will conduct a systematic review to summarize the existing knowledge on mediators of treatment outcome and theories of change in psychotherapy for young people with personality disorders. In particular, we will evaluate whether mediators appear to be common or specific to particular age groups, treatment models, or outcome domains (e.g., psychosocial functioning, life quality, and adverse treatment effects).Method: We will follow the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. Electronic databases (PubMed and PsycINFO) have been systematically searched for prospective, longitudinal, and case–control designs of psychological treatment studies, which examine mediators published in English. Participants will be young people between 10 and 30years of age who suffer from subclinical personality symptoms or have a personality disorder diagnosis and receive an intervention that aims at preventing, ameliorating, and/or treating psychological problems.Results: The results will be published in a peer-reviewed journal and at conference presentations and will be shared with relevant stakeholder groups. The data set will be made available to other research groups following recommendations of the open science initiative. Databases with the systematic search will be made openly available following open science initiatives. The review has been registered in PROSPERO (evaluation is pending, registration number ID 248959).Implications: This review will deliver a comprehensive overview on the empirical basis to contribute to the further development of psychological treatments for young people with personality disorders.
Psychological Distress and Use of Psychotropic Drugs Among University Students—the SHoT Study, Norway
Authors: Bojanić Ivana , Sund Erik R. , Bjerkeset Ottar , Sivertsen Børge , Sletvold Hege 
Published: September 2021

Background: Students pursuing higher education are struggling with psychological distress, which in turn may negatively affect their academic self-efficacy and study progress. Although psychotropic drug use is widespread and increasing, patterns of psychotropic drug use among students are not well-known.Aim: To describe prevalence and gender differences in psychotropic drug use among Norwegian students in higher education, and to examine associations with level of psychological distress.Methods: The study is based on data from the Norwegian Student's Health and Well-being Study (SHoT), 2018, a national survey including all fulltime students aged 18–35 years in higher education. Our sample included 49,836 students, 69% females. Use of psychotropic drugs and psychological distress (The Hopkins Symptoms Checklist [HSCL-25]) were self-reported. Generalised linear models were used to assess associations between psychological distress and psychotropic drug use.Results: Psychotropic drug use was more frequent among female than male students: 4 vs. 2% daily antidepressants usage; 5 vs. 3% last month use of anxiolytics/tranquillisers; and 8 vs. 5% last month use of hypnotics. In contrast, male students reported use of performance enhancing drugs more often than females (7 vs. 5%). Adjusted associations between high level of psychological distress (HSCL-25 ≥ 2.0) and use of psychotropics, showed an about 2-fold increased relative risk, largely consequent across drug classes and genders.Conclusion: Prevalence and gender patterns of intake of the most common psychotropic drug classes among Norwegian students are comparable to previous studies. Unexpectedly, among students with moderate to severe psychological distress, the patterns of psychotropic drug use were more or less identical between genders.
Atmospheric Correction of DSCOVR EPIC: Version 2 MAIAC Algorithm
Authors: Lyapustin A. , Wang Y. , Go S. , Choi M. , Korkin S. , Huang D. , Knyazikhin Y. , Blank K. , Marshak A. 
Published: September 2021

The Earth Polychromatic Imaging Camera (EPIC) onboard the Deep Space Climate Observatory (DSCOVR) provides multispectral images of the sunlit disk of Earth since 2015 from the L1 orbit, approximately 1.5 million km from Earth toward the Sun. The NASA’s Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm has been adapted for DSCOVR/EPIC data providing operational processing since 2018. Here, we describe the latest version 2 (v2) MAIAC EPIC algorithm over land that features improved aerosol retrieval with updated regional aerosol models and new atmospheric correction scheme based on the ancillary bidirectional reflectance distribution function (BRDF) model of the Earth from MAIAC MODIS. The global validation of MAIAC EPIC aerosol optical depth (AOD) with AERONET measurements shows a significant improvement over v1 and the mean bias error MBE = 0.046, RMSE = 0.159, andR= 0.77. Over 66.7% of EPIC AOD retrievals agree with the AERONET AOD to within ± (0.1 + 0.1AOD). We also analyze the role of surface anisotropy, particularly important for the backscattering view geometry of EPIC, on the result of atmospheric correction. The retrieved BRDF-based bidirectional reflectance factors (BRF) are found higher than the Lambertian reflectance by 8–15% at 443 nm and 1–2% at 780 nm for EPIC observations near the local noon. Due to higher uncertainties, the atmospheric correction at UV wavelengths of 340, 388 nm is currently performed using a Lambertian approximation.
Survey Research on Health Inequalities: Exploring the Availability of Indicators of Multiple Forms of Capital in Canadian Datasets
Authors: Godley Jenny , Fundytus Katrina , Stones Cheyanne , Peller Peter , McLaren Lindsay 
Published: September 2021

Objective: Much of the extensive quantitative research linking socio-economic position (SEP) and health utilizes three common indicators: income, occupation and education. Existing survey data may enable researchers to include indicators of additional forms of capital in their analyses, permitting more nuanced consideration of the relationship between SEP and health. Our objective was to identify the breadth of survey questions related to economic, cultural, and social capital available through Statistics Canada surveys, and the extent to which those surveys also include health measures.Methods: We compiled a list of all population-based Statistics Canada surveys, and developed a broad list of potential indicators of forms of capital. We systematically searched the surveys for those indicators and health measures, analyzing their co-occurrence.Results: Traditional SEP indicators were present in 73% of surveys containing health measures, while additional indicators of social and cultural capital were available in 57%.Conclusion: Existing national survey data represent an under-exploited opportunity for research examining the relationship between various forms of capital and health in Canada. Future empirical explorations of these data could enrich our theoretical understanding of health inequities.
Metode Penyapihan Ventilasi Mekanik Di Intensive Care Unit: Studi Literatur
Authors: Sarinti Sarinti , Utami Reni Sulung , Prasetyo Awal 
Published: September 2021

Latar belakang : Pasien di ICU ( Intensive Care Unit ) yang membutuhkan bantuan ventilasi mekanik hampir mencapai 30% dari total pasien. Ventilasi mekanik yang digunakan dalam jangka panjang dapat meningkatkan resiko terjadinya mortalitas, dan ventilator associated pneumonia sehingga diperlukan perencanaan penyapihan yang tepat. Tujuan : Studi literatur ini bertujuan untuk mengidentifikasi metode penyapihan pasien dari ventilasi mekanik di ICU. Metode : Penelusuran literatur dilakukan melalui database Google scholar dan Google search dengan menggunakan kata kunci weaning mechanical ventilation, weaning protocol, critical care nursing. Literatur yang digunakan dari tahun 1997-2015 dalam bentuk full text. Literatur yang sesuai kriteria inklusi dan eksklusi dianalisis secara narasi. Hasil: Penelusuran mendapatkan 7 artikel penelitian yang menunjukkan metode penyapihan pasien dari ventilasi mekanik. Metode penyapihan dari ke 7 artikel tersebut adalah metode protokol dan non protokol. Metode non protokol misalnya physician direct weaning ( PDW ) dan collaboration weaning plan ( CWP ). Metode penyapihan dengan protokol antara lain : nurse` protokol directed weaning ( NPDW ) dan protokol base weaning ( PBW ). Kesimpulan : Metode penyapihan protokol menunjukkan hasil lebih efektif dibandingkan metode non protokol. Kata Kunci: Penyapihan Ventilasi Mekanik, Protokol Penyapihan, Keperawatan Kritis Methode of Weaning from Mechanical Ventilation in Intensive Care Unit : Study Literature ABSTRACT Back ground : patients in the ICU who require mechanical ventilation assistance almost 30% of the total patients. Mechanical ventilation is used in the long term can increase the risk of mortality and ventilator associated pneumonia so that proper planning is necessary weaning. Objectives : the literature study aims to identify methods of weaning patients from mechanical ventilation in the ICU. Methods : the literature study search pass through by Google scholar and Google search using keywords weaning mechanical ventilation, weaning protocol, critical care nursing. Literature is used from the year 1997-2015 in the form of full text. Appropriate literature inclusion and exclusion criteria were analyzed narrative. Results : search get 7 articles studies showing methods of weaning patients from mechanical ventilation. Method of weaning to the article 7 is the method protocol and non-protocol. Methods of non protocols eg physician-direct weaning ( PDW ) and collaboration weaning plan ( CWP ). Methods of weaning protocols include: nurse` protocol directed weaning (NPDW) and protocols base weaning ( PBW ). Conclusion : the method of weaning protocol shows the results more effective than non - protocol methods Key word : weaning mechanical ventilation; weaning protocol; critical care nursing
Uñas de Lindsay
Authors: Vargas-Rubio Víctor Alonso 
Published: September 2021

Mujer de 69 años con enfermedad renal crónica estadio V en hemodiálisis por nefropatía diabética e hipertensión arterial, acudió al Servicio de Emergencia de nuestro hospital por fiebre, malestar general, disuria, polaquiuria, náuseas y vómitos; y, con funciones vitales estables y una coloración blanquecina en la mitad proxi al de las uñas y una coloración marrón en la mitad distal.
Approccio sistemico applicato a territori siti UNESCO
Authors: Bistagnino Luigi 
Published: September 2021

Um bem histórico ou um território específico foi lentamente moldado ao longo dos anos por uma ação coletiva que o consolidou, e que hoje podemos apreciar e usufruir. Contudo, essa percepção vem sendo gradualmente modificada pela exploração comercial superficial e individualista, prejudicando o meio ambiente e a população local. Esse foi o motivo pelo qual o projeto apresentado nesse artigo foi desenvolvido. Para tanto, foram selecionados três territórios, localizados ao sul da cidade de Turim – Itália, considerados como Patrimônio Cultural pela UNESCO. O objetivo foi despertar a consciência de que é possível valorizar os bens deixados como herança e, concomitantemente, promover o bem-estar dos habitantes locais inseridos em seu contexto social, cultural, produtivo e econômico. Por meio da aplicação da metodologia do Design Sistêmico, foi possível: i) compreender, de maneira holística, os territórios envolvidos; ii) verificar que grande parte da produção dos alimentos consumidos é advinda do exterior, o que provoca problemas de saúde e prejuízos à economia local; iii) redefinir o sistema territorial de produção de alimentos, satisfazendo as exigências alimentares da população, gerando novos postos de trabalho e fonte de renda. A Abordagem Sistêmica traz uma riqueza de recursos, comportamentos e relações sociais que envolvem aqueles que visitam um lugar desconhecido, incentivando-os a voltar para viver novas experiências, um turismo experiencial que participa do ritmo de vida no território, uma relação cultural enriquecedora, e não um surto turístico superficial.
BAKTERI BACILLUS SUBTILLS SEBAGAI AGEN SELF HEALING CONCRETE DENGAN VARIASI PERSENTASE DAN NILAI PH
Authors: Gumelar Fauzan , Rika Nuraini  
Published: September 2021

Material yang selalu digunakan sebagai pengisi dari struktur adalah beton, dikarenakan memiliki kuat tekan yang kuat dan pembuatannya mudah. Sampai saat ini, telah banyak dilakukan berbagai inovasi terhadap beton dan salah satunya adalah dengan memanfaatkan bakteri agar beton dapat memiliki kemampuan untuk menutup kerusakan berupa retakan secara mandiri atau biasa disebut dengan self healing concrete. Tujuan pada penelitian kali ini adalah untuk mengetahui pengaruh dari beton dengan bahan tambah bakteri bacillus subtilis yang dienkapsulasi dengan persentase sebesar 0,5% dan 1%. Beton tersebut akan diuji kuat tekan dan dibandingkan dengan beton normal. Setelah itu, beton dengan bahan tambah kapsul bakteri akan direndam dalam air selama 14 hari dengan nilai pH yang berbeda- beda sebagai pengujian self healing concrete. Hasil penelitian menunjukkan bahwa nilai kuat tekan beton normal 25,18 Mpa, beton dengan bahan tambah enkapsulasi bakteri sebesar 0,5% memiliki nilai kuat tekan 24,51 Mpa, dan beton dengan bahan tambah enkapsulasi bakteri sebesar 1% memiliki nilai kuat tekan 26,20 Mpa. Pengujian self healing concrete menunjukkan bahwa beton dengan bahan tambah enkapsulasi bakteri sebesar 0,5% pada perendaman air dengan nilai pH 7 selama 14 hari, dinilai yang paling baik dalam menutupi retak pada beton.
Reliable time forecasting of structural and technological, operational and technical and economic indicators of marine equipment products
Authors: Ляховский Е.Е. , Герман Г.В. 
Published: September 2021

Увеличение объёмов баз данных при создании и использовании изделий морской техники (МТ) диктует необходимость снижения размерности этих баз с одновременным повышением достоверности и точности получаемых оценок. Многомерные свойства вновь создаваемых наукоёмких изделий МТ проявляются в сферах, отстоящих от момента принятия решений по их созданию, на значительный временной период (до года и более). Указанное обстоятельство диктует необходимость прогноза всех видов затрат, начиная с ранних этапов разработки технического задания, составления предконтрактного проекта, технической подготовки производства, в условиях неполной известности информации. Вот почему для получения оценок предлагается использовать только известные определяющие параметры. Математические модели оценки абсолютных удельных показателей, отнесённых к значению определяющих параметров (во времени) наиболее полно отвечают решению указанных проблем и доказали свою состоятельность. Научно-методические подходы, изложенные в статье, предлагаются к использованию в отечественном судостроении, замыкая «обратную связь» учёта требований системы производства и использования изделий МТ при принятии решений по их созданию.
The increase in the volume of databases for the creation and use of marine equipment products (MT) dictates the need to reduce the dimension of these databases while increasing the reliability and accuracy of the estimates obtained. The multidimensional properties of newly created high-tech MT products are manifested in areas that are separated from the moment of making decisions on their creation for a significant time period (up to a year or more). This circumstance dictates the need to forecast all types of costs, starting from the early stages of the development of the terms of reference, drawing up a pre-contract project, technical preparation of production, in conditions of incomplete information. That is why it is proposed to use only known defining parameters to obtain estimates. Mathematical models for estimating absolute specific indicators related to the value of determining parameters (in time) most fully meet the solution of these problems and have proved their viability. The scientific and methodological approaches outlined in the article are proposed for use in domestic shipbuilding, closing the "feedback" of taking into account the requirements of the production system and the use of MT products when making decisions on their creation.
Evaluating the effectiveness of a shipping company environmental protection
Authors: Каминский В.Ю. , Скороходов Д.А. , Турусов С.Н. 
Published: September 2021

В статье сформирована структура показателей оценки безопасности для транспортных средств морского и внутреннего водного транспорта. Каждый компонент структуры включает от двух до пяти составляющих. Обоснованы группы оценочных критериев: функциональные, экономические, социальные, экологические и информационные. Установлено, что в качестве основных критериев безопасности водных транспортных средств целесообразно рассматривать значения концентраций опасных веществ (экологическая безопасность), уровень шума на судах (экологическая безопасность), уровень аварийности и травматизма на судне (функциональная безопасность), уровень ущерба от аварий и инцидентов на судне (функциональная безопасность) и уровень риска, как интегральный критерий безопасности. Показаны причины возникновения технических аварийных ситуаций, которые связаны с недостатками в организации работы судовых экипажей, с низкой квалификацией личного состава, с ошибочными действиями береговых служб управления, технического обслуживания и судоремонта. Утверждается, что для получения количественных показателей безопасности водной транспортной системы необходимо разработать модели безопасности для её элементов с учетом разнообразных ситуаций и определить вероятностные характеристики частных событий (аварий и инцидентов), входящих в модели безопасности.
The structure of safety assessment indicators for sea and inland water transport vehicles is formed in the article. Each component of the structure includes from two to five components. The groups of evaluation criteria are justified: functional, economic, social, environmental and informational. It is established that as the main criteria for the safety of water vehicles, it is advisable to consider the values of concentrations of hazardous substances (environmental safety), the noise level on ships (environmental safety), the level of accidents and injuries on the ship (functional safety), the level of damage from accidents and incidents on the ship (functional safety) and the level of risk as an integral safety criterion. The reasons for the occurrence of technical emergencies are shown, which are associated with shortcomings in the organization of the work of ship crews, low qualification of personnel, with erroneous actions of the coastal management services, maintenance and ship repair. It is argued that in order to obtain quantitative indicators of the safety of a water transport system, it is necessary to develop safety models for its elements taking into account various situations and to determine the probabilistic characteristics of particular events (accidents and incidents) included in the safety models.