bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial Aspects of Participation in Competitive Sports Among Older Athletes: A Scoping Review
Authors: Cannella Valentina , Villar Feliciano , Serrat Rodrigo , Tulle Emmanuelle 
Published: June 2021

AbstractBackground and ObjectivesIn the last decade, sport has been considered a tool in active aging to maintain physical fitness, improve mental well-being, and form social relationships among older people. However, a thorough psychosocial understanding of the phenomenon of older athletes competing in sports events is lacking. Most research has focused on competitive sports participation in the young population. This study analyzes the general state of knowledge of competitive sports participation among athletes aged 50 years and older from a psychosocial perspective.Research Design and MethodsWe followed the 5-step process outlined by Arksey and O’Malley. After the search in 4 electronic databases, 69 peer-reviewed articles met the inclusion criteria.ResultsThe findings indicate that psychosocial research into older people’s participation in competitive sports has grown moderately in the last decade. While intrapersonal and interpersonal aspects have dominated the academic psychosocial discourse on older athletes’ competitive sports participation, aspects related to the environment/community and policy have largely been overlooked.Discussion and ImplicationsWe identified several critical gaps in the literature, classified into conceptual (e.g., lesser attention to personality, emotional, and cognitive aspects), methodological (e.g., longitudinal studies almost absent), and diverse aspects (e.g., focus on a wide indiscriminate age range; few comparisons between types of sports; underrepresentation of some nation or world regions as well as few cross-national comparative studies). These research gaps hint at opportunities that future research on older people’s participation in competitive sports should address.
Resituating Henrician Ireland: imperium, prophecy and Reformation between the Atlantic and Eurasian worlds, 1514–47
Authors: Leduc James 
Published: June 2021

Abstract
An intellectual-cultural history of sovereignty in Henrician Ireland, this article mines government writings and printed pamphlets to argue for Ireland’s integration within the dynastic strife, spiritual controversies and imperial ambitions that bridged the ‘New World’, the North Atlantic and the Mediterranean in the early Reformation. Its conclusions are twofold: that the Henrician Reformation galvanized the political theologies of interfaith representation in Ireland, and that the island felt the weight of European Atlantic colonialism earlier than has hitherto been appreciated. The article suggests the need to reconsider Henrician Ireland in its entanglements with the political-theological Reformation worlds of inter-imperial rivalry.
MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8
Authors: Wang Xin , Zhu Lihuan , Lin Xing , Huang Yangyun , Lin Zhaoxian 
Published: June 2021

Abstract
The study aims to explore the interaction between miR-133a-3p and cell division cycle associated 8 (CDCA8) in oesophageal cancer (EC) and their effect on malignant behaviour of EC cells. Differential miRNAs and mRNAs were obtained from The Cancer Genome Atlas (TCGA) database. Quantitative real-time PCR (qRT-PCR) was used to detect the expression levels of miR-133a-3p and CDCA8 mRNA in EC cells. Western blot was used to detect the expression of CDCA8 protein. CCK-8, flow cytometry and Transwell assays were conducted to detect cell proliferation, cell cycle and apoptosis, as well as migration and invasion, respectively. The targeting relationship between miR-133a-3p and CDCA8 was verified by dual-luciferase reporter gene assay. In EC, miR-133a-3p expression was evidently low and CDCA8 expression was prominently high. MiR-133a-3p downregulated CDCA8 expression. A range of cell function experiments revealed that CDCA8 promoted the proliferation, migration and invasion of EC cells, reduced cell cycle arrest in G0/G1 phase and inhibited cell apoptosis, while miR-133a-3p could reverse the above effects by regulating CDCA8. MiR-133a-3p is a crucial tumour suppressor miRNA in EC, playing a tumour suppressor role by targeting CDCA8.
Adjudication at the Service of Diplomacy: The Enrica Lexie Case
Authors: Tanzi Attila M 
Published: June 2021

Abstract
The article addresses the Enrica Lexie case as an example of integration between adjudicative and diplomatic means of dispute settlement. It illustrates the case focusing on the Tribunal’s assessment of the scope of its jurisdiction and of the applicable law. The article is organised in four parts, next to the introduction. First, it places the case in the context of the relationship between adjudication and diplomacy in the settlement of international disputes. Second, it illustrates the case as a dispute over the interpretation and application of UNCLOS. Third, it addresses the relevance of the immunity of the marines for the purposes of the jurisdiction of the Tribunal and the applicable law. Finally, it concludes with few general policy remarks on the beneficial impact of the Award for the disputing and third Parties, as to the balancing of the interests of flag-States and costal-States in interpreting and applying freedom of navigation.
Radiopharmaceutical preparations: what are the legislative differences across Europe?
Authors: Giustiniani Matteo , Musazzi Umberto M , Minghetti Paola , Paolino Donatella 
Published: June 2021

AbstractObjectivesRadiopharmaceuticals, since the discovery of the first medical application of radioactive isotope, have been essential therapeutics for the diagnosis and treatment of numerous diseases. Since the Directive 2001/83/EC entered in force, European regulatory authorities have established a harmonised framework to set quality requirements for the industrial production of radiopharmaceuticals. However, little is known about the harmonisation of extemporaneous preparation of radiopharmaceutical preparations (EPRPs) among European countries. In this context, this study aims to provide an overview of the national regulatory framework on the production of EPRPs of five European countries (i.e. UK, Spain, France, Germany and Italy).MethodsFive different national regulatory frameworks were compared based on the results of a literature search on electronic databases (i.e. PubMed, Google scholar).Key findingsUnlike industrially produced radiopharmaceuticals, the results highlighted that the regulatory framework on EPRPs is still not fully harmonised at the European level and many provisions are regulated by local national laws. Similarities and differences exist among the European countries, both regarding quality standards and educational courses the operators involved in the preparation of EPRPs have to attend.ConclusionsThe regulatory framework on the EPRPs is still not harmonised at the European level affecting the access to therapies of European citizens who are not equally guaranteed when an extemporaneous radiopharmaceutical has to be prepared to meet their needs.
Rewilding crops for climate resilience: economic analysis and de novo domestication strategies
Authors: Razzaq Ali , Wani Shabir Hussain , Saleem Fozia , Yu Min , Zhou Meixue , Shabala Sergey 
Published: June 2021

Abstract
To match predicted population growth, annual food production should be doubled by 2050. This is not achievable by current agronomical and breeding practices, due to the impact of climate changes and associated abiotic stresses on agricultural production systems. Here, we analyze the impact of global climate trends on crop productivity and show that the overall loss in crop production from climate-driven abiotic stresses may exceed US$170 billion year–1 and represents a major threat to global food security. We also show that abiotic stress tolerance had been present in wild progenitors of modern crops but was lost during their domestication. We argue for a major shift in our paradigm of crop breeding, focusing on climate resilience, and call for a broader use of wild relatives as a major tool in this process. We argue that, while molecular tools are currently in place to harness the potential of climate-resilient genes present in wild relatives, the complex polygenic nature of tolerance traits remains a major bottleneck in this process. Future research efforts should be focused not only on finding appropriate wild relatives but also on development of efficient cell-based high-throughput phenotyping platforms allowing assessment of the in planta operation of key genes.
Design and Assessment of a Mobile Health Care Solution for the Military Pediatrician: The DHA Pediatrics App
Authors: Reeves Patrick T , Royall Matthew , Spencer Steven , Rogers Philip L , Durning Steven J , Samuel Anita , O’Meara Kevin , Gorman Gregory 
Published: June 2021

ABSTRACTIntroductionMobile health technology design and use by patients and clinicians have rapidly evolved in the past 20 years. Nevertheless, the technology has remained in silos of practices, patients, and individual institutions. Uptake across integrated health systems has lagged.Materials and MethodsIn 2015, the authors designed a mobile health application (App) aimed at augmenting the capabilities of clinicians who care for children within the Military Health System (MHS). This App incorporated a curated, system-based collection of Clinical Practice Guidelines, access to emergency resuscitation cards, call buttons for local market subspecialty and inpatient teams, links to residency academic calendars, and other web-based resources. Over the next 5 years, three Plan-Do-Study-Act cycles facilitated multiple enhancements for the App which eventually transitioned from the Android/iOS stores to a web browser. The “People At the Centre of Mobile Application Development” tool which has validity evidence captured user experience. The team assessed the App’s global effectiveness using Google Analytics. A speed test measured time saved and accuracy of task completion for clinicians using the App compared to non-users. Finally, MHS medical librarians critiqued the App using a questionnaire with validity evidence. The Walter Reed National Military Medical Center Institutional Review Board reviewed the study and deemed it exempt.ResultsClinician respondents (n = 68 complete responses across six MTFs, 51% graduate medical trainees representing a 7.4% response rate of active duty pediatrician forces) perceived the App to have appropriate qualities of efficiency, effectiveness, learnability, memorability, errors, satisfaction, and cognitive properties following App use in clinical practice. Google Analytics demonstrated more than 1,000 unique users on the App from May 1, 2020 to January 20, 2021. There were 746 instances (26% of all sessions) when a user navigated between more than one military treatment facility. App users were faster and more accurate at task completion during a digital scavenger hunt. Medical librarians measured the App to have acceptable usefulness, accuracy, authority, objectivity, timeliness, functionality, design, security, and value.ConclusionsThe App appears to be an effective tool to extend a clinician’s capabilities and inter-professional communication between world-wide users and six MHS markets. This App was designed—and used—for a large health care network across a wide geographic footprint. Next steps are establishing an enduring chain of App champions for continued updates and sharing the App’s code with other military medical disciplines and interested civilian centers.
The Efficacy of Bamlanivimab in Reducing Emergency Department Visits and Hospitalizations in a Real-world Setting
Authors: Corwin Douglas S , Ender Peter T , Sahu Nitasa , Durgham Ryan A , McGorry Dennis M , Rahman Awan , Stoltzfus Jill , Jahre Jeffrey A 
Published: June 2021

Abstract
Bamlanivimab, a monoclonal antibody targeting the spike protein of severe acute respiratory syndrome coronavirus 2, is available for ambulatory treatment of coronavirus disease 2019 (COVID-19). This real-world study confirms the efficacy of bamlanivimab in reducing hospital admissions and emergency department visits among high-risk outpatients with mild to moderate COVID-19 illness and reveals a trend toward improved mortality.
Delayed admissions and efficacy of steroid use in patients with critical and severe COVID-19: an apprehensive approach
Authors: Akhtar Hashaam , Khalid Sundas , Rahman Fazal-ur- , Ali Sabahat , Afridi Maham , Khader Yousef S , Hassan Faheem , Akhtar Nasim , Khan Muhammad Mujeeb , Ikram Aamer 
Published: June 2021

Abstract

Background
Inadvertent delays in access to appropriate therapeutic interventions in high-risk group coronavirus disease 2019 (COVID-19) patients contribute to mortality in patients with severe/critical disease presentation.

Objectives
The aim of this study was to determine the effect of timely admission to the hospital on mortality of patients with severe/critical COVID-19. Another secondary aspect of this study was to observe the efficacy of time-dependent use of corticosteroids on mortality of critical/severe COVID-19 patients.

Methods
Clinical data of 659 patients with severe/critical COVID-19, admitted to four major tertiary care hospitals from the Islamabad-Rawalpindi region of Pakistan was retrospectively collected from a period February–August 2020. Multivariate logistic regression analysis was carried out to determine the predictors of mortality in severe/critical COVID-19 patients.

Results
Out of a total of 659 patients, 469 (71.2%) patients died. Age &gt; 60 years, presence of hypertension, heart disease and kidney disease along with late admission (&gt;5 days) were significant predictors of mortality in patients with severe/critical COVID-19.

Conclusions
The study highlights the importance of well-timed provision of appropriate medical interventions control COVID-19-associated mortality.
Regulation and Characterization of Mutants of fixABCX in Rhizobium leguminosarum
Authors: Webb Isabel U. C. , Xu Jiabao , Sánchez-Cañizares Carmen , Karunakaran Ramakrishnan , Ramachandran Vinoy K. , Rutten Paul J. , East Alison K. , Huang Wei E. , Watmough Nicholas J. , Poole Philip S. 
Published: June 2021

Symbiosis between Rhizobium leguminosarum and Pisum sativum requires tight control of redox balance in order to maintain respiration under the microaerobic conditions required for nitrogenase while still producing the eight electrons and sixteen molecules of ATP needed for nitrogen fixation. FixABCX, a cluster of electron transfer flavoproteins essential for nitrogen fixation, is encoded on the Sym plasmid (pRL10), immediately upstream of nifA, which encodes the general transcriptional regulator of nitrogen fixation. There is a symbiotically regulated NifA-dependent promoter upstream of fixA (PnifA1), as well as an additional basal constitutive promoter driving background expression of nifA (PnifA2). These were confirmed by 5′-end mapping of transcription start sites using differential RNA-seq. Complementation of polar fixAB and fixX mutants (Fix− strains) confirmed expression of nifA from PnifA1 in symbiosis. Electron microscopy combined with single-cell Raman microspectroscopy characterization of fixAB mutants revealed previously unknown heterogeneity in bacteroid morphology within a single nodule. Two morphotypes of mutant fixAB bacteroids were observed. One was larger than wild-type bacteroids and contained high levels of polyhydroxy-3-butyrate, a complex energy/reductant storage product. A second bacteroid phenotype was morphologically and compositionally different and resembled wild-type infection thread cells. From these two characteristic fixAB mutant bacteroid morphotypes, inferences can be drawn on the metabolism of wild-type nitrogen-fixing bacteroids. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Care Delivery in Cancer Patients With Asymptomatic COVID-19 Infection in a Tertiary, Safety-Net Hospital in Houston, Texas
Authors: Chen Nan , Jotwani Aparna , Li Ang 
Published: June 2021

Objectives:
Current coronavirus disease 2019 (COVID-19) guidelines recommend delaying clinical care for all affected cancer patients, including incidentally diagnosed asymptomatic infections. This retrospective study conducted in a safety-net hospital in Houston examines the care delivery of asymptomatic COVID-19 cancer patients and how their diagnosis affected their care.

Methods:
A retrospective chart review was conducted on cancer patients with a documented positive SARS-CoV-2 laboratory result in the Harris Health System in Houston, Texas. Patient demographics, treatment delays, and patient outcomes were analyzed.

Results:
Thirteen percent (n=24) of all patients with cancer and COVID-19 diagnosis (n=181) were asymptomatic and 96% had a solid organ malignancy. Among asymptomatic patients, 44% (n=11) of them experienced a median treatment delay of 33 days and 21% (n=5) transitioned to hospice. No patients had progression of disease at first evaluation after recovering from COVID-19 diagnosis. Asymptomatic patients were more likely to have a worse ECOG performance status, metastatic disease, and charity insurance as compared with symptomatic patients.

Conclusions:
This study supports the safety of our current isolation guidelines for all COVID-19 asymptomatic cancer patients. While treatment delays occurred, they did not appear to significantly impact overall care. Differences in care delivery and health care usage patterns between symptomatic and asymptomatic patients demonstrate the need for continued studies in vulnerable populations.
Outcomes of Immune Checkpoint Inhibitor–related Diarrhea or Colitis in Cancer Patients With Superimposed Gastrointestinal Infections
Authors: Ma Weijie , Gong Zimu , Abu-Sbeih Hamzah , Peng Yuanzun , Peng Frederick , Zou Fangwen , Charabaty Aline , Okhuysen Pablo C. , McQuade Jennifer L. , Altan Mehmet , Zhang Hao Chi , Thomas Anusha S. , Wang Yinghong 
Published: June 2021

Background and Objective:
Immune-mediated diarrhea and colitis (IMDC) is a common adverse event in cancer patients receiving immune checkpoint inhibitors (ICIs). Gastrointestinal (GI) infections can co-occur with IMDC, and its impact on the course and outcome of IMDC remains unclear.

Patients and Methods:
We retrospectively reviewed cancer patients who received ICIs and developed IMDC between January 2015 and September 2019. GI multiplex panel is used to assess GI infection. The study group included patients with positive infection except those who are only positive for Clostridioides difficile or cytomegalovirus. The control group is IMDC patients with negative infection using frequency matching. Patients’ disease course and outcome were compared between groups.

Results:
A total of 72 patients with IMDC were included: 22 in the study group and 50 as control. Escherichia coli of different pathotypes was observed in 17 patients. Five patients had viral infections, for example, adenovirus, norovirus, and sapovirus. Patients with GI infections more frequently had grade 3 or 4 colitis (43% vs. 18%, P=0.041). Overall, GI infections were not associated with different risks of IMDC recurrence or overall survival. Antibiotics treatment did not affect the requirement for infliximab or vedolizumab but relate to a higher risk of IMDC recurrence (50.0% vs. 0.0%, P=0.015).

Conclusions:
In our study, concomitant GI infections are associated with more severe symptoms in IMDC patients. Antimicrobial treatment did not circumvent the need for immunosuppressive therapy for IMDC or improve the clinical outcome. Concomitant GI infection was not associated with a higher risk of IMDC recurrence or poor overall survival.
Established Trauma Triage Score Predicts Risk of Falling After Femoral Neck Fracture Arthroplasty Surgery
Authors: Konda Sanjit R. , Perskin Cody R. , Parola Rown , Littlefield Connor P. , Egol Kenneth A. 
Published: June 2021

ABSTRACT

Introduction:
The purpose of this study is to determine whether the Score for Trauma Triage in the Geriatric and Middle-Aged (STTGMA) patients is able to predict fall, fracture, periprosthetic fracture, or dislocation risk after femoral neck fracture arthroplasty surgery.

Methods:
Four hundred one patients who underwent hip arthroplasty surgery after a femoral neck fracture at one urban academic medical center were stratified into groups based on their risk scores assigned at femoral neck fracture presentation. The cohort was reviewed for the occurrence of postdischarge falls, secondary fractures, and prosthetic dislocations that resulted in a presentation to the emergency department (ED) after discharge from their hip fracture surgery. The incidence and timing of these complications after discharge were compared between the low-risk and high-risk groups.

Results:
The low-risk group included 201 patients, and the high-risk group included 200 patients. The high-risk group had significantly more postdischarge falls resulting in ED presentation (49 vs. 32, p = .035) that occurred significantly sooner (12.6 vs. 18.3 months, p = .034) after discharge.

Conclusions:
The STTGMA model was able to successfully stratify patients who are at a higher risk of sustaining a fall after an arthroplasty procedure for a femoral neck fracture.
Expansion of telehealth in primary care during the COVID-19 pandemic: benefits and barriers
Authors: Dhaliwal Jaspreet K. , Hall Tara D. , LaRue Julie L. , Maynard Susan E. , Pierre Peterson E. , Bransby Kristen A. 
Published: June 2021

ABSTRACT
The novel coronavirus disease 2019 (COVID-19) pandemic remarkably accelerated the adoption of telemedicine in outpatient settings. Out of necessity, virtual care became a preferred and default modality of extending primary care services to health care consumers. Although telemedicine is not a new concept and had been used in many organizations and health systems, the COVID-19 pandemic scaled up its use in a variety of health care settings. Telehealth's use in primary care was particularly important because of the need to maintain continuity of care for successful coordination of chronic disease management. This article examines the benefits of telehealth, including continuity of care, convenience of access to care, screening and triaging, and social distancing and disease prevention. The utilization of telehealth and financial implications are discussed, including reimbursement and cost-effectiveness. Barriers and challenges are addressed, including methods for successful implementation of nurse practitioner (NP) in primary care practices as a response to the COVID-19 pandemic. The leadership role of the NP in telehealth is discussed and implementation guidance is provided.