bluuebunny/crossref_metadata_2025_split huggingface dataset:
New class of exact solutions to Einstein–Maxwell-dilaton theory on four-dimensional Bianchi type IX geometry
Authors: Fahim Bardia H. , Ghezelbash Masoud 
Published: July 2021

AbstractWe construct new classes of cosmological solution to the five dimensional Einstein–Maxwell-dilaton theory, that are non-stationary and almost conformally regular everywhere. The base geometry for the solutions is the four-dimensional Bianchi type IX geometry. In the theory, the dilaton field is coupled to the electromagnetic field and the cosmological constant term, with two different coupling constants. We consider all possible solutions with different values of the coupling constants, where the cosmological constant takes any positive, negative or zero values. In the ansatzes for the metric, dilaton and electromagnetic fields, we consider dependence on time and two spatial directions. We also consider a special case of the Bianchi type IX geometry, in which the geometry reduces to that of Eguchi–Hanson type II geometry and find a more general solution to the theory.
State-space models reveal bursty movement behaviour of dance event visitors
Authors: Rutten Philip , Lees Michael H. , Klous Sander , Sloot Peter M. A. 
Published: July 2021

AbstractPedestrian movements during large crowded events naturally consist of different modes of movement behaviour. Despite its importance for understanding crowd dynamics, intermittent movement behaviour is an aspect missing in the existing crowd behaviour literature. Here we analyse movement data generated from nearly 600 Wi-Fi sensors during large entertainment events in the Johan Cruijff ArenA football stadium in Amsterdam. We use the state-space modeling framework to investigate intermittent motion patterns. Movement models from the field of movement ecology are used to analyse individual pedestrian movement. Joint estimation of multiple movement tracks allows us to investigate statistical properties of measured movement metrics. We show that behavioural switching is not independent of external events, and the probability of being in one of the behavioural states changes over time. In addition, we show that the distribution of waiting times deviates from the exponential and is best fit by a heavy-tailed distribution. The heavy-tailed waiting times are indicative of bursty movement dynamics, which are here for the first time shown to characterise pedestrian movements in dense crowds. Bursty crowd behaviour has important implications for various diffusion-related processes, such as the spreading of infectious diseases.
Diamondiferous lamproites of Ingashi field, Siberian craton
Authors: Kostrovitsky Sergey I. , Yakovlev Dmitry A. , Sharygin Igor S. , Gladkochub Dmitry P. , Donskaya Tatyana V. , Tretiakova Irina G. , Dymshits Anna M. , Sekerin Alexander P. , Malkovets Vladimir G. 
Published: July 2021

Abstract

Ingashi lamproite dykes are the only known primary sources of diamond in the Irkutsk district (Russia) and the only non-kimberlitic one in the Siberian craton. The Ingashi lamproite field is situated in the Urik-Iya graben within the Prisayan uplift of the Siberian craton. The phlogopite-olivine lamproites contain olivine, talc, phlogopite, serpentine, chlorite, olivine, garnet, chromite, orthopyroxene, clinopyroxene as well as Sr-F-apatite, monazite, zircon, armolcolite, priderite, potassium Mg-arfvedsonite, Mn-ilmenite, Nb-rutile and diamond. The only ultramafic lamprophyre dyke is composed mainly of serpentinized olivine and phlogopite in the talc-carbonate groundmass and is similar to Ingashi lamproites accessory assemblage with the same major element compositions. Trace element and Sr-Nd isotopic relationships of the Ingashi lamproites are similar to classic lamproites. Different dating methods have provided the ages of lamproites: 1481 Ma (Ar-Ar phlogopite), 1268 Ma (Rb-Sr whole rock) and 300 Ma (U-Pb zircon). Ingashi lamproite ages are controversial and require additional study. The calculated pressure of 3.5 GPa
max
for clinopyroxenes indicates that lamproite magma originated deeper than 100 km. A Cr-in-garnet barometer shows a 3.7–4.3 GPa
min
and derivation of Ingashi lamproites deeper than 120 km in depth. Based on the range of typical cratonic geotherms and the presence of diamonds, the Ingashi lamproite magma originated at a depth greater than 155 km.
Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity
Authors: Zhou Xiaolei , Singh Madhurendra , Sanz Santos Gema , Guerlavais Vincent , Carvajal Luis A. , Aivado Manuel , Zhan Yue , Oliveira Mariana M.S. , Westerberg Lisa S. , Annis D. Allen , Johnsen John Inge , Selivanova Galina 
Published: July 2021

AbstractThe repression of repetitive elements is an important facet of p53's function as a guardian of the genome. Paradoxically, we found that p53 activated by MDM2 inhibitors induced the expression of endogenous retroviruses (ERV) via increased occupancy on ERV promoters and inhibition of two major ERV repressors, histone demethylase LSD1 and DNA methyltransferase DNMT1. Double-stranded RNA stress caused by ERVs triggered type I/III interferon expression and antigen processing and presentation. Pharmacologic activation of p53 in vivo unleashed the IFN program, promoted T-cell infiltration, and significantly enhanced the efficacy of checkpoint therapy in an allograft tumor model. Furthermore, the MDM2 inhibitor ALRN-6924 induced a viral mimicry pathway and tumor inflammation signature genes in patients with melanoma. Our results identify ERV expression as the central mechanism whereby p53 induction overcomes tumor immune evasion and transforms tumor microenvironment to a favorable phenotype, providing a rationale for the synergy of MDM2 inhibitors and immunotherapy.Significance:We found that p53 activated by MDM2 inhibitors induced the expression of ERVs, in part via epigenetic factors LSD1 and DNMT1. Induction of IFN response caused by ERV derepression upon p53-targeting therapies provides a possibility to overcome resistance to immune checkpoint blockade and potentially transform “cold” tumors into “hot.”This article is highlighted in the In This Issue feature, p. 2945
Veterinary phytotherapy in Algeria
Authors: Berghiche Amine , Djebrane Chahinése , Belahcene Nabiha , Boulebda Nadji 
Published: July 2021

Currently, the use of alternative medicine is necessary, even in animals. Our study focused on the valorisation of the use of herbal products in Algerian veterinary medicine. This study is based on a 6-month exploratory survey of 257 private practicing veterinarians, followed by a study of the bacteriological activity of the essential oil of the Pistacia lentiscus plant. The survey results generally indicate that private veterinarians support phytotherapy as an alternative to conventional drugs in several areas and species. Also, the results of research conducted on the antibacterial activity of Pistacia lentiscus essential oil show that it inactivates 50% of the bacterial strains. This confirms the well defined role of this medicinal plant used as an alternative in veterinary medicine.
Predictors of the Use of Mineralocorticoid Receptor Antagonists in Patients With Left Ventricular Dysfunction Post‐ST‐Segment–Elevation Myocardial Infarction
Authors: Wong Eric C. , Fordyce Christopher B. , Wong Graham , Lee Terry , Perry‐Arnesen Michele , Mackay Martha , Singer Joel , Cairns John A. , Turgeon Ricky D. 
Published: July 2021

Background
Guidelines recommend mineralocorticoid receptor antagonist (MRA) use in patients with left ventricular ejection fraction ≤40% following a myocardial infarction plus heart failure or diabetes mellitus, based on mortality benefit in the EPHESUS (Eplerenone Post‐Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) trial. The objective of this study was to evaluate the real‐world utilization of MRAs for patients with ST‐segment–elevation myocardial infarction (STEMI) with left ventricular dysfunction.

Methods and Results
The prospective, population‐based, Vancouver Coastal Health Authority STEMI database was linked with local outpatient cardiology records from 2007 to 2018. EPHESUS criteria were used to define post‐STEMI MRA eligibility (left ventricular ejection fraction ≤40% plus clinical heart failure or diabetes mellitus, and no dialysis‐dependent renal dysfunction). The primary outcome was MRA prescription among eligible patients at discharge and the secondary outcome was MRA prescription within 3 months postdischarge. Of 2691 patients with STEMI, 317 (12%) were MRA eligible, and 70 (22%) eligible patients were prescribed an MRA at discharge. Among eligible patients with no MRA at discharge, 12/126 (9.5%) with documented postdischarge follow‐up were prescribed an MRA within 3 months. In multivariable analysis, left ventricular ejection fraction (odds ratio [OR], 1.55 per 5% left ventricular ejection fraction decrease; 95% CI, 1.26–1.90) and calendar year (OR, 1.23 per year, 95% CI, 1.11–1.37) were associated with MRA prescription at discharge. Other prespecified variables were not associated with MRA prescription.

Conclusions
In this contemporary STEMI cohort, only 1 in 4 MRA‐eligible patients were prescribed an MRA within 3 months following hospitalization despite high‐quality evidence for use. Novel decision‐support tools are required to optimize pharmacotherapy decisions during hospitalization and follow‐up to target this gap in post‐STEMI care.
Cabo Verde giant gecko: how many units for conservation?
Authors: Delgado Katelene , Lopes Evandro P. , Vasconcelos Raquel 
Published: July 2021

Abstract
Tarentola gigas (Bocage, 1875) is the largest gecko living in the Cabo Verde Archipelago. It is subdivided into two subspecies, one confined to the Branco Islet, Tarentola gigas brancoensis (Schleich, 1984), and another to the Raso Islet, Tarentola gigas gigas (Bocage, 1875). These islets were classified as Integral Natural Reserves and further studies on the species are needed to outline more assertive conservation measures. Thus, this study aims to integrate for the first time genetic, morphometric and meristic data to test if there are significant differences between these two taxonomical groups that would support the subspecific designation. The results indicated that they are two closely related subspecies, with some visible differences in size and shape, possibly related to diet, habitat conditions or drift. Given the conservation status of the species, this should be further investigated, aiming an adequate management of these two evolutionarily significant units.
When the Beasts Lost Their Voice: Fables, Qiṣaṣ al-anbiyāʾ and Dramatic Irony in The Case of the Animals versus Man of the Ikhwān al-Ṣafāʾ
Authors: Sánchez Ignacio 
Published: July 2021

Abstract
The most famous piece of the collection of Rasāʾil written by the Ikhwān al-Ṣafāʾ is probably the animal fable included in Epistle 22, known in its English translation as “The Case of the Animals versus Man before the King of the Jinn.” The complexity and thematic richness of the work allows multiple readings and it has often been interpreted as a fable denouncing cruelty against animals. The abrupt ending of the work recognising the superiority of men, however, seems to contradict the ecological spirit that animates the debate. This article approaches this contradiction from a narratological point of view. Together with the genre of animal fables, especially the Kalīla wa-Dimna, the Ikhwān al-Ṣafāʾ rely heavily on the tradition of the qiṣaṣ al-anbiyāʾ to recreate a setting that would have evoked in the educated audiences both the descriptions of the pre-Adamite era, where animals were free and had the ability to speak, and the consequences of the creation of Adam and his preordained fall. The recognition of these parallelisms and other proleptic clues creates a gap between the expectations of the characters and those of the readers, which can be interpreted as dramatic irony.
WMO Evaluation of Two Extreme High Temperatures Occurring in February 2020 for the Antarctic Peninsula Region
Authors: Francelino Márcio Rocha , Schaefer Carlos , Skansi Maria de Los Milagros , Colwell Steve , Bromwich David H. , Jones Phil , King John C. , Lazzara Matthew A. , Renwick James , Solomon Susan , Brunet Manola , Cerveny Randall S. 
Published: July 2021

ABSTRACTTwo reports of Antarctic region potential new record high temperature observations (18.3°C, 6 February 2020 at Esperanza station and 20.8°C, 9 February 2020 at a Brazilian automated permafrost monitoring station on Seymour Island) were evaluated by a World Meteorological Organization (WMO) panel of atmospheric scientists. The latter figure was reported as 20.75°C in the media. The panel considered the synoptic situation and instrumental setups. It determined that a large high pressure system over the area created föhn conditions and resulted in local warming for both situations. Examination of the data and metadata of the Esperanza station observation revealed no major concerns. However, analysis of data and metadata of the Seymour Island permafrost monitoring station indicated that an improvised radiation shield led to a demonstrable thermal bias error for the temperature sensor. Consequently, the WMO has accepted the 18.3°C value for 1200 LST 6 February 2020 (1500 UTC 6 February 2020) at the Argentine Esperanza station as the new “Antarctic region (continental, including mainland and surrounding islands) highest temperature recorded observation” but rejected the 20.8°C observation at the Brazilian automated Seymour Island permafrost monitoring station as biased. The committee strongly emphasizes the permafrost monitoring station was not badly designed for its purpose, but the project investigators were forced to improvise a nonoptimal radiation shield after losing the original covering. Second, with regard to media dissemination of this type of information, the committee urges increased caution in early announcements as many media outlets often tend to sensationalize and mischaracterize potential records.
The “U-Tube”: An improved aspirated temperature system for mobile meteorological observations, especially in severe weather
Authors: Waugh Sean M. 
Published: July 2021

AbstractObtaining quality air temperature measurements in complex mesoscale environments, such as thunderstorms or frontal zones, is problematic, and particularly challenging from a moving platform. For some time mobile weather platforms known as Mobile Mesonets (MMs) have used custom aspirated temperature shields. The original design was known as the “J-Tube”, which addresses some but not all of the unique problems associated with mobile temperature measurements. For VORTEX-2 2009, a second, well documented shield, the R.M. Young (RMY) 43408 was included but was also found to have certain shortcomings in some severe weather environments. Between the end of VORTEX2 2009 and the start of VORTEX2 2010, a third and new shield called the “U-tube” was designed, tested and installed.Reported here are the results of efforts to better characterize the J-Tube, RMY 43408, and the U-Tube. Several tests designed to isolate key aspects of a radiation shield’s performance, such as performance in rain, high solar radiation, varying wind conditions, and general response time were completed. A period of intercomparison between the three shields during the 2010 season of VORTEX 2 is also used to highlight each shield being used in “real world” conditions. Results indicate that the U-Tube has several significant advantages over the J-tube and 43408 in terms of aspiration rate, sampling efficiency, performance during rain, variable winds, and high solar radiation periods, as well as response time. Given these results, the U-tube should be utilized for mobile observations going forward.
Is Call Karma Real? Resident After-Hours On-Call Imaging at the University of Saskatchewan: An Assessment of Call Volumes Including Inter-Resident Variability
Authors: Huynh James , Horne David , Bryce Rhonda , Leswick David A 
Published: July 2021

Purpose: Quantify resident caseload during call and determine if there are consistent differences in call volumes for individuals or resident subgroups. Methods: Accession codes for after-hours computed tomography (CT) cases dictated by residents between July 1, 2012 and January 9, 2017 were reviewed. Case volumes by patient visits and body regions scanned were determined and categorized according to time period, year, and individual resident. Mean shift Relative Value Units (RVUs) were calculated by year. Descriptive statistics, linear mixed modeling, and linear regression determined mean values, differences between residents, associations between independent variables and outcomes, and changes over time. Consistent differences between residents were assessed as a measure of good or bad luck / karma on call. Results: During this time there were 23,032 patients and 30,766 anatomic regions scanned during 1,652 call shifts among 32 residents. Over the whole period, there were on average 10.6 patients and 14.3 body regions scanned on weekday shifts and 22.3 patients and 29.4 body regions scanned during weekend shifts. Annually, the mean number of patients, body regions, and RVUs scanned per shift increased by an average of 0.2 (1%), 0.4 (2%), and 1.2 (5%) (all p < 0.05) respectively in regression models. There was variability in call experiences, but only 1 resident had a disproportionate number of higher volume calls and fewer lower volume shifts than expected. Conclusions: Annual increases in scan volumes were modest. Although residents’ experiences varied, little of this was attributable to consistent personal differences, including luck or call karma.
Implementation of a clinical pharmacist-led service to optimize management of refractory chemotherapy-induced nausea and vomiting in adult hematology/oncology clinic
Authors: Quinn Caroline S , Bergsbaken Jason J , Blessinger Emily J , Piccolo Jennifer K 
Published: July 2021

Objective Chemotherapy-induced nausea and vomiting (CINV) is a common and potentially debilitating adverse effect of chemotherapy. Refractory CINV can be particularly difficult to control. This report provides details on the implementation and evaluation of a pharmacist-led program for the management of refractory CINV in hematology and oncology clinics. Methods A pharmacist-led program open to adult outpatients with refractory CINV was implemented at University of Wisconsin. Pharmacists conducted baseline and follow-up assessments, provided patient education, and started, discontinued, and/or adjusted antiemetics as clinically necessary for all enrolled patients. Retrospective chart review was used to describe the proportion of patients whose CINV improved through pharmacist intervention, effect of the program on antiemetic adherence, categorization of pharmacist interventions, and duration of patient enrollment. Results Forty-six patients were enrolled between February 2019 and January 2020. Forty-one patients (89.1%) had an overall reduction in their nausea and vomiting from baseline. Eleven patients (23.9%) met criteria for nonadherence to prescribed antiemetics at baseline; all patients were adherent at unenrollment. A total of 111 pharmacist interventions were made. The most common intervention was addition of new breakthrough antiemetic. The least common intervention was dose escalation of a previously prescribed antiemetic. The average number of interventions made per patient was 2.5. On average, patients were enrolled in the program for 16.6 days and met with a pharmacist three times. Conclusion Implementation of this program standardized and streamlined pharmacist involvement with refractory CINV. Enrollment resulted in a measurable reduction in nausea and/or vomiting for patients with refractory CINV.
Acute gout flare of bilateral first metatarsophalangeal joints due to ibrutinib use in chronic lymphocytic leukemia
Authors: Kaur Jaspreet , Tuler Shahaf , Dasanu Constantin A 
Published: July 2021

Introduction Bruton tyrosine kinase inhibitors represent important tools in the therapeutic armamentarium against chronic lymphocytic leukemia (CLL) and other B-lymphoproliferative disorders. Case Report We describe herein a unique 65-year-old patient who presented with bilateral foot pain four months after starting treatment with ibrutinib for CLL. Of note, the patient had previously been diagnosed with gout, and was taking allopurinol prophylactically at the time of the event. Compliance with allopurinol was in excess of 99%. Yet, he was diagnosed with acute gout flare of bilateral first metatarsophalangeal (MTP) joints. Management & Outcome: Ibrutinib dose was reduced by one third, and the patient’s gout flare up was treated with ibuprofen as needed. After symptoms abated, ibrutinib was continued at 2/3rds of the dose, with an excellent CLL control. The patient tolerated this dose without any further adverse effects. Discussion/Conclusions: We have reported a unique side effect of acute bilateral first MTP joint gout flare likely triggered by ibrutinib use for CLL while the patient was taking a xanthine oxidase inhibitor. The mechanism by which ibrutinib caused this phenomenon remains to be elucidated.
The Impact of Adherence to Disease-Modifying Therapies on Functional Outcomes in Veterans with Multiple Sclerosis
Authors: Rabadi Meheroz H , Just Kimberly , Xu Chao 
Published: July 2021

Background: Patients who adhere to their DMTs have lower rate of MS-related relapses and disability. Objective: We sought to determine the adherence rate to disease-modifying therapies (DMTs) and its impact on functional outcome(s) in veterans with multiple sclerosis (MS). Method: We reviewed the electronic records of 279 veterans with MS who were periodically followed in our MS clinic. We compared 3 groups of patients, defined according to their adherence to DMTs (non-adherent; poorly adherent; adherent) on their effect on disability progression and time to sustained EDSS score of 6. Results: There were 148 (53%) veterans with MS who were non-adherent to any DMT medication(s) while of the 131 (47%) veterans who were taking medications, 118 (42%) had a good- and 13 (5%) had poor-adherence. The mean age at MS onset was 36.6 (± 11.2) and mean duration of MS for the sample was 24 ± 13.5 years. The mean initial EDSS and TFIM scores were 4.09 ± 2.9 SD and 104 ± 25.7 for the study sample. The change in MMSE, TFIM scores, and time to sustained EDSS score of 6 significantly favored the good- compared to the non-adherence group ( P < .01). Conclusion: This study suggests that veterans with MS who adhered to their DMTs had less decline in their MS-related cognition, disease severity and disability compared to non- and poorly-adherent groups even after adjusting for age, gender, MS duration, and type. Time to EDSS score of 6 was significantly prolonged in the good-adherence group.