bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dust changes in Sakurai’s Object: new PAHs and SiC with coagulation of submicron-sized silicate dust into 10 μm-sized melilite grains
Authors: Bowey Janet E 
Published: May 2021

ABSTRACT
6–14 μm Spitzer spectra obtained at 6 epochs between 2005 April and 2008 October are used to determine temporal changes in dust features associated with Sakurai’s Object (V4334 Sgr), a low mass post-AGB star that has been forming dust in an eruptive event since 1996. The obscured carbon-rich photosphere is surrounded by a 40-milliarcsec torus and 32 arcsec PN. An initially rapid mid-infrared flux decrease stalled after 2008 April 21. Optically thin emission due to nanometre-sized SiC grains reached a minimum in 2007 October, increased rapidly between 2008 April 21–30 and more slowly to 2008 October. 6.3-μm absorption due to PAHs increased throughout. 20 μm-sized SiC grains might have contributed to the 6–7 μm absorption after 2007 May. Mass estimates based on the optically thick emission agree with those in the absorption features if the large SiC grains formed before 1999 May and PAHs formed in 1999 April–June. Estimated masses of PAH and large-SiC grains in 2008 October, were 3 × 10−9 M⊙ and 10−8 M⊙, respectively. Some of the submicron-sized silicates responsible for a weak 10 μm absorption feature are probably located within the PN because the optical depth decreased between 2007 October and 2008 October. 6.9-μm absorption assigned to ∼10 μm-sized crystalline melilite silicates increased between 2005 April and 2008 October. Abundance and spectroscopic constraints are satisfied if $\lesssim$2.8 per cent of the submicron-sized silicates coagulated to form melilites. This figure is similar to the abundance of melilite-bearing calcium–aluminium-rich inclusions in chondritic meteorites.
Tightening the girdle: phylotranscriptomics of Polyplacophora
Authors: Moles Juan , Cunha Tauana Junqueira , Lemer Sarah , Combosch David J , Giribet Gonzalo 
Published: May 2021

ABSTRACT
The phylogenetic relationships within the molluscan class Polyplacophora (chitons) have been studied using morphology, traditional Sanger markers and mitogenomics, but, to date, no analysis has been carried out using transcriptomic and genome-wide data. Here, we leverage the power of transcriptomes to investigate the chiton phylogeny to test current classification schemes and the position of Callochitonidae, a family whose phylogenetic position and taxonomic assignation are uncertain because of conflicting results from past studies. Using multiple data matrices with different taxon occupancy thresholds and inference methods, including both concatenated and coalescence-based approaches, we find a consistent resolution of the chiton phylogeny. Our results support a system with the orders Lepidopleurida, Chitonida and Callochitonida, with the latter two as sister groups. This resolution is compatible with recent mitogenomic results and rejects the position of Callochiton as a member of Chitonina.
Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator
Authors: Liu Fenmei , Su Zihui , Chen Peng , Tian Xiaolin , Wu Lijie , Tang Dong-Jie , Li Peifang , Deng Haiteng , Ding Pengfei , Fu Qiang , Tang Ji-Liang , Ming Zhenhua 
Published: May 2021

Abstract
The zinc uptake regulator (Zur) is a member of the Fur (ferric uptake regulator) family transcriptional regulators that plays important roles in zinc homeostasis and virulence of bacteria. Upon zinc perception, Zur binds to the promoters of zinc responsive genes and controls their transcription. However, the mechanism underlying zinc-mediated Zur activation remains unclear. Here we report a 2.2-Å crystal structure of apo Zur from the phytopathogen Xanthomonas campestris pv. campestris (XcZur), which reveals the molecular mechanism that XcZur exists in a closed inactive state before regulatory zinc binding. Subsequently, we present a 1.9-Å crystal structure of holo XcZur, which, by contrast, adopts an open state that has enough capacity to bind DNA. Structural comparison and hydrogen deuterium exchange mass spectrometry (HDX-MS) analyses uncover that binding of a zinc atom in the regulatory site, formed by the hinge region, the dimerization domain and the DNA binding domain, drives a closed-to-open conformational change that is essential for XcZur activation. Moreover, key residues responsible for DNA recognition are identified by site-directed mutagenesis. This work provides important insights into zinc-induced XcZur activation and valuable discussions on the mechanism of DNA recognition.
DrugComb update: a more comprehensive drug sensitivity data repository and analysis portal
Authors: Zheng Shuyu , Aldahdooh Jehad , Shadbahr Tolou , Wang Yinyin , Aldahdooh Dalal , Bao Jie , Wang Wenyu , Tang Jing 
Published: May 2021

AbstractCombinatorial therapies that target multiple pathways have shown great promises for treating complex diseases. DrugComb (https://drugcomb.org/) is a web-based portal for the deposition and analysis of drug combination screening datasets. Since its first release, DrugComb has received continuous updates on the coverage of data resources, as well as on the functionality of the web server to improve the analysis, visualization and interpretation of drug combination screens. Here, we report significant updates of DrugComb, including: (i) manual curation and harmonization of more comprehensive drug combination and monotherapy screening data, not only for cancers but also for other diseases such as malaria and COVID-19; (ii) enhanced algorithms for assessing the sensitivity and synergy of drug combinations; (iii) network modelling tools to visualize the mechanisms of action of drugs or drug combinations for a given cancer sample and (iv) state-of-the-art machine learning models to predict drug combination sensitivity and synergy. These improvements have been provided with more user-friendly graphical interface and faster database infrastructure, which make DrugComb the most comprehensive web-based resources for the study of drug sensitivities for multiple diseases.
Middle Meningeal Artery Embolization Versus Conventional Treatment of Chronic Subdural Hematomas
Authors: Enriquez-Marulanda Alejandro , Gomez-Paz Santiago , Salem Mohamed M , Mallick Akashleena , Motiei-Langroudi Rouzbeh , Arle J E , Stippler Martina , Papavassiliou Efstathios , Alterman Ron L , Ogilvy Christopher S , Moore Justin M* , Thomas Ajith J 
Published: May 2021

Abstract

BACKGROUND
Middle meningeal artery (MMA) embolization is an emerging minimally invasive endovascular technique for chronic subdural hematoma (cSDH). Currently, limited literature exists on its safety and efficacy compared with conventional treatment (open-surgical-evacuation-only).

OBJECTIVE
To compare MMA embolization to conventional treatment.

METHODS
Retrospective analysis of patients with cSDHs treated with MMA embolization in a single center from 2018 to 2019 was performed. Comparisons were made with a historical conventional treatment cohort from 2006 to 2016. Propensity score matching analysis was used to assemble a balanced group of subjects.

RESULTS
A total of 357 conventionally treated cSDH and 45 with MMA embolization were included. After balancing with propensity score matching, a total of 25 pairs of cSDH were analyzed. Comparing the embolization with the conventional treatment group yielded no significant differences in complications (4% vs 4%; P > .99), clinical improvement (82.6% vs 83.3%; P = .95), cSDH recurrence (4.3% vs 21.7%; P = .08), overall re-intervention rates (12% vs 24%; P = .26), modified Rankin scale >2 on last follow-up (17.4% vs 32%; P = .24), as well as mortality (0% vs 12%; P = .09). Radiographic improvement at last follow-up was significantly higher in the open surgery cohort (73.9% vs 95.6%; P = .04). However, there was a trend for lengthier last follow-up for the historical cohort (72 vs 104 d; P = .07).

CONCLUSION
There was a trend for lower recurrence and mortality rates in the embolization era cohort. There were significantly higher radiological improvement rates on last follow-up in the surgical only cohort era. There were no significant differences in complications and clinical improvement.
Fields of Forel Brain Stimulation Improves Levodopa-Unresponsive Gait and Balance Disorders in Parkinson's Disease
Authors: Rocha Maria Sheila Guimarães , de Freitas Julian Leticia , Costa Carlos Daniel Miranda , de Oliveira Maira Okada , Terzian Paulo Roberto , Queiroz João Welberthon Matos , Ferraz Jamana Barbosa , Tatsch João Fellipe Santos , Soriano Diogo Coutinho , Hamani Clement , Godinho Fabio 
Published: May 2021

Abstract

BACKGROUND
Gait and balance disturbance are challenging symptoms in advanced Parkinson's disease (PD). Anatomic and clinical data suggest that the fields of Forel may be a potential surgical target to treat these symptoms.

OBJECTIVE
To test whether bilateral stimulation centered at the fields of Forel improves levodopa unresponsive freezing of gait (FOG), balance problems, postural instability, and falls in PD.

METHODS
A total of 13 patients with levodopa-unresponsive gait disturbance (Hoehn and Yahr stage ≥3) were included. Patients were evaluated before (on-medication condition) and 1 yr after surgery (on-medication-on-stimulation condition). Motor symptoms and quality of life were assessed with the Unified Parkinson's Disease Rating scale (UPDRS III) and Quality of Life scale (PDQ-39). Clinical and instrumented analyses assessed gait, balance, postural instability, and falls.

RESULTS
Surgery improved balance by 43% (95% confidence interval [CI]: 21.2-36.4 to 35.2-47.1; P = .0012), reduced FOG by 35% (95% CI: 15.1-20.3 to 8.1-15.3; P = .0021), and the monthly number of falls by 82.2% (95% CI: 2.2-6.9 to −0.2-1.7; P = .0039). Anticipatory postural adjustments, velocity to turn, and postural sway measurements also improved 1 yr after deep brain stimulation (DBS). UPDRS III motor scores were reduced by 27.2% postoperatively (95% CI: 42.6-54.3 to 30.2-40.5; P < .0001). Quality of life improved 27.5% (95% CI: 34.6-48.8 to 22.4-37.9; P = .0100).

CONCLUSION
Our results suggest that DBS of the fields of Forel improved motor symptoms in PD, as well as the FOG, falls, balance, postural instability, and quality of life.
Landscape cover type, not social dominance, is associated with the winter movement patterns of Snowy Owls in temperate areas
Authors: McCabe Rebecca A , Therrien Jean-François , Wiebe Karen L , Gauthier Gilles , Brinker David , Weidensaul Scott , Elliott Kyle 
Published: May 2021

AbstractMigrating animals occur along a continuum from species that spend the nonbreeding season at a fixed location to species that are nomadic during the nonbreeding season, essentially continuously moving. Such variation is likely driven by the economics of territoriality or heterogeneity in the environment. The Snowy Owl (Bubo scandiacus) is known for its complex seasonal movements, and thus an excellent model to test these ideas, as many individuals travel unpredictably along irregular routes during both the breeding and nonbreeding seasons. Two possible explanations for this large variation in the propensity to move are (1) dominance hierarchies in which dominant individuals (adult females in this case) monopolize some key, consistent resources, and move less than subdominants; and (2) habitat heterogeneity in which individuals foraging in rich and less heterogenic environments are less mobile. We analyzed fine-scale telemetry data (global positioning system [GPS]/global system for mobile communication [GSM]) from 50 Snowy Owls tagged in eastern and central North America from 2013 to 2019, comparing space use during the winter period according to sex and age, and to land cover attributes. We used variograms to classify individuals as nomadic (58%) or range-resident (42%), and found that nomadic owls had ten times larger wintering areas than range-resident owls. The frequency of nomadism was similar in socially-dominant adult females, immatures, and males. However, nomadism increased from west to east, and north to south, and was positively associated with the use of water and negatively associated with croplands. We conclude that many individual Snowy Owls in Eastern North America are nomadic during the nonbreeding season and that movement patterns during this time are driven primarily by extrinsic factors, specifically heterogeneity in habitat and prey availability, as opposed to intrinsic factors associated with spacing behavior, such as age and sex.
Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
Authors: Łukasik Zuzanna , Gracey Eric , Venken Koen , Ritchlin Christopher , Elewaut Dirk 
Published: May 2021

Abstract
Several lines of evidence point towards the central role of IL-23 as a crucial inflammatory mediator in the pathogenesis of SpA—a group of inflammatory arthritic diseases whose symptoms span the skin, gastrointestinal tract and joints. While therapeutic blockade of IL-23 proved successful in the treatment of IBD, psoriatic skin disease and peripheral SpA, it failed in patients suffering from SpA with predominantly axial involvement. Here we review state-of-the-art discoveries on IL-23 signalling pathways across target tissues involved in SpA. We discuss the discrepancies in resident IL-23–responding cells and their downstream activities across skin, gut and joint that shape the unique immunological landscape of SpA.
SEMI-AUTOMATED 3D SEGMENTATION OF PELVIC REGION BONES IN CT VOLUMES FOR THE ANNOTATION OF MACHINE LEARNING DATASETS
Authors: Jeuthe Julius , Sánchez José Carlos González , Magnusson Maria , Sandborg Michael , Tedgren Åsa Carlsson , Malusek Alexandr 
Published: May 2021

Abstract
Automatic segmentation of bones in computed tomography (CT) images is used for instance in beam hardening correction algorithms where it improves the accuracy of resulting CT numbers. Of special interest are pelvic bones, which—because of their strong attenuation—affect the accuracy of brachytherapy in this region. This work evaluated the performance of the JJ2016 algorithm with the performance of MK2014v2 and JS2018 algorithms; all these algorithms were developed by authors. Visual comparison, and, in the latter case, also Dice similarity coefficients derived from the ground truth were used. It was found that the 3D-based JJ2016 performed better than the 2D-based MK2014v2, mainly because of the more accurate hole filling that benefitted from information in adjacent slices. The neural network-based JS2018 outperformed both traditional algorithms. It was, however, limited to the resolution of 1283 owing to the limited amount of memory in the graphical processing unit (GPU).
Network embeddedness in illegal online markets: endogenous sources of prices and profit in anonymous criminal drug trade
Authors: Duxbury Scott W , Haynie Dana L 
Published: May 2021

AbstractAlthough economic sociology emphasizes the role of social networks for shaping economic action, little research has examined how network governance structures affect prices in the unregulated and high-risk social context of online criminal trade. We consider how overembeddedness—a state of excessive interconnectedness among market actors—arises from endogenous trade relations to shape prices in illegal online markets with aggregate consequences for short-term gross illegal revenue. Drawing on transaction-level data on 16 847 illegal drug transactions over 14 months of trade in a ‘darknet’ drug market, we assess how repeated exchanges and closure in buyer–vendor trade networks nonlinearly influence prices and short-term gross revenue from illegal drug trade. Using a series of panel models, we find that increases in closure and repeated exchange raise prices until a threshold is reached upon which prices and gross monthly revenue begin to decline as networks become overembedded. Findings provide insight into the network determinants of prices and gross monthly revenue in illegal online drug trade and illustrate how network structure shapes prices in criminal markets, even in anonymous trade environments.
An exploratory analysis to identify behavior change techniques of implementation interventions associated with the implementation of healthy canteen policies
Authors: Yoong Sze Lin , Hall Alix , Stacey Fiona , Nathan Nicole , Reilly Kathryn , Delaney Tessa , Sutherland Rachel , Hodder Rebecca , Straus Sharon , Wolfenden Luke 
Published: May 2021

Abstract
Empirical studies to disentangle the effects of multicomponent implementation interventions are needed to inform the development of future interventions. This study aims to examine which behavior change techniques (BCTs) primarily targeting canteen manager are associated with school’s healthy canteen policy implementation. This is a secondary data analysis from three randomized controlled trials assessing the impact of a “high,” “medium,” and “low” intensity intervention primarily targeting canteen managers on school’s implementation of a healthy canteen policy. The policy required primary schools to remove all “red” (less healthy items) or “banned” (sugar sweetened beverages) items from regular sale and ensure that “green” (healthier items) dominated the menu (&gt;50%). The delivery of BCTs were retrospectively coded. We undertook an elastic net regularized logistic regression with all BCTs in a single model. Five k-fold cross-validation elastic net models were conducted. The percentage of times each strategy remained across 1,000 replications was calculated. For no “red” or “banned” items (n = 162), the strongest BCTs were: problem solving, goal setting (behavior), and review behavior goals. These BCTs were identified in 100% of replications as a strong predictor in the cross-validation elastic net models. For the outcome relating to &gt;50% “green” items, the BCTs problem solving, instruction on how to perform behavior and demonstration of behavior were the strongest predictors. Two strategies were identified in 100% of replications as a strong (i.e., problem solving) or weak predictor (i.e., feedback on behavior). This study identified unique BCTs associated with the implementation of a healthy canteen policy.
Associations between pesticide mixtures applied near home during pregnancy and early childhood with adolescent behavioral and emotional problems in the CHAMACOS study
Authors: Hyland Carly , Bradshaw Patrick T. , Gunier Robert B. , Mora Ana M. , Kogut Katherine , Deardorff Julianna , Sagiv Sharon K. , Bradman Asa , Eskenazi Brenda 
Published: May 2021

Background:
Studies suggest that exposure to pesticides during pregnancy and early childhood is associated with adverse child neurodevelopment. Research to date has focused primarily on exposure to single pesticides or pesticide classes in isolation; there are little data on the effect of exposure to pesticide mixtures on child and adolescent neurodevelopment.

Methods:
Using California’s Pesticide Use Reporting database, we estimated agricultural pesticide use within 1 km of the home during the prenatal and postnatal (ages 0–5 years) periods among participants in the Center for the Health Assessment for Mothers and Children of Salinas (CHAMACOS) birth cohort. We implemented a Bayesian Hierarchical linear mixed-effects model to examine associations with maternal- and youth-reported behavioral and emotional problems from the Behavior Assessment System for Children, 2nd edition (BASC-2) at ages 16 and 18 years (n = 593).

Results:
We observed mostly null associations between pesticide applications and neurobehavioral outcomes. There were some trends of modestly increased internalizing behaviors and attention problems in association with organophosphate insecticide use near the home during the prenatal period. In the postnatal period, a two-fold increase in glyphosate applications was associated with more youth-reported depression (β = 1.2, 95% credible intervals [CrI] = 0.2, 2.2), maternal-reported internalizing behaviors (β = 1.23, 95% CrI = 0.2, 2.3), and anxiety (β = 1.2, 95% CrI = 0.2, 2.3). We observed some protective associations with imidacloprid during the prenatal period, particularly in sex-specific analyses.

Conclusions:
We found only some subtle associations between some pesticides and neurobehavioral outcomes. This study extends previous work by considering potential exposure to mixtures of pesticides.
Educational Inequalities in Ill-Health Retirement Among Middle- and Older-Aged Workers in Korea
Authors: Jung Jiyoun , Lee Jongin , Lee Yu Min , Lee Dong-Wook , Kim Hyoung-Ryoul , Kang Mo-Yeol 
Published: May 2021

Objectives:
To identify differences in risk of ill-health retirement (IHR) between groups with different levels of education and examine this difference with respect to working conditions and health-related factors.

Methods:
This study analysed the longitudinal data of 1691 paid workers aged 45 to 79 years from the Korean Longitudinal Study of Aging. Multivariate Cox regression analyses were conducted to identify the predictors and build a prediction model for IHR according to different final education levels.

Results:
Over the 10-year follow-up, 208 workers exited work because of poor health. Clear educational inequalities in reason of retirement and increased risk of IHR in low, intermediate, and high educational groups were observed.

Conclusions:
Our results suggest an educational gradient for IHR among Korean male workers and revealed gender differences in the risk of IHR.
COVID-19 Workplace Outbreaks by Industry Sector and Their Associated Household Transmission, Ontario, Canada, January to June, 2020
Authors: Murti Michelle , Achonu Camille , Smith Brendan T. , Brown Kevin A. , Kim Jin Hee , Johnson James , Ravindran Saranyah , Buchan Sarah A. 
Published: May 2021

Objective:
To analyze workplace outbreaks by industry sector in the first wave of the pandemic, and associated household cases.

Methods:
Number, size, and duration of outbreaks were described by sector, and outbreak cases were compared to sporadic cases in the same time frame. Address matching identified household cases with onset ≥2 days before, ≥2 days after, or within 1 day of the workplace outbreak case.

Results:
There were 199 outbreaks with 1245 cases, and 68% of outbreaks and 80% of cases belonged to (1) Manufacturing, (2) Agriculture, Forestry, Fishing, Hunting, (3) Transportation and Warehousing. There were 608 household cases associated with 339 (31%) outbreak cases, increasing the burden of illness by 56%.

Conclusions:
Workplace outbreaks primarily occurred in three sectors. Prevention measures should target industry sectors at risk to prevent spread in and out of the workplace.