bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-mobility ecosystem innovation – impact on downstream supply chain management processes. Is India ready for inevitable change in auto sector?
Authors: Serohi Ajay 
Published: July 2021

Purpose
The purpose of this study is to understand the specific reasons why developed countries could easily start implementing innovative alternative fuel vehicles (e.g. electric vehicles or EVs) while the implementation in developing countries looks so far-fetched, with respect to infrastructure and downstream activities, and suggest the steps that can be taken to effectively address these issues.

Design/methodology/approach
This research undertakes case study – Tesla (USA), Mahindra and Mahindra (India) and Tata Motors to bring out the problems being faced by manufacturers from developing countries vis-a-vis the developed countries. The consumers’ side has been adequately represented though an in-depth survey. An analysis is also carried out as to how Tesla has accrued competitive leverage by innovating and vertical integration of up as well as downstream systems.

Findings
EV infrastructure remains grossly inadequate in developing countries like India. Two key areas that remain significantly unexplored are the installation of charging stations at parking lots and at the housing clusters and lack of competitive leverage in the services, processes and other downstream systems due to limited research and development capabilities. The performance metrics of domestic EVs lag those of conventional vehicles as well as foreign competitors like Tesla. Range anxiety is ranked as number one in the major concerns among the potential mass buyers of electric vehicles in India.

Originality/value
The value of the paper lies in an in-depth analysis of the relationship between horizontal and vertical perspectives as well as the impact of the product eco-system innovation on both the upstream as well as downstream nodes in the supply chain. Whereas the consumer attitudes and perspectives on e-mobility are inferred from a survey, the impact analysis matrix is used for analyzing the competitive leverage of Tesla through several features in the upstream, downstream and servitization.
The impact of corporate social responsibility on financial distress: empirical evidence
Authors: Farooq Muhammad , Noor Amna , Qureshi Shahzadah Fahad 
Published: July 2021

Purpose
The present study aims to explore the role of corporate social responsibility (CSR) on the likelihood of financial distress for a sample of 139 Pakistan Stock Exchange (PSX) listed firms throughout 2008–2019.

Design/methodology/approach
Panel logistic regression (PLR) and the dynamic generalized method of moments (GMM) estimator are used to examine the impact of CSR on financial distress. The investment in CSR measures through a multidimensional financial approach which comprises the sum of the contribution made by the company in the form of charitable donation, employees’ welfare and research and development, whereas the Altman Z-score and ZM-Score are used as an indicator of financial distress. The higher the Z-score lower will be the probability of financial distress, whereas the higher ZM score shows a greater probability of financial distress risk.

Findings
The authors find a significant negative impact of CSR on financial distress in both PLR and GMM models. This finding is consistent with the stakeholder view of CSR, as an investment in CSR not only aligns the interest between shareholders and stakeholders but also mitigates the risk of financial distress as well.

Research limitations/implications
Like other studies, the present study is not free from limitations. First, financial firms skipped from the sample, although literature witnesses a lot of studies highlight the financial firms' commitment to achieving CSR goals. Second, financial distress occurs in different stages, the authors fail to establish linkage CSR engagements at different stages of CSR. In the future, researchers can make a valuable addition by covering these missing links in present studies.

Practical implications
The findings of this study provide more insight to corporate managers and investors about the association between the quality of investment in CSR and the degree of financial distress, concerning Pakistani firms. Furthermore, this study contributes to the existing literature by adding new evidence from developing countries such as Pakistan which are helpful for regulatory bodies and policymakers in the formulation of long-term CSR strategies to manage financial distress.

Originality/value
The study extends the body of existing literature on CSR and the likelihood of financial distress in Pakistan. The results suggest that policymakers may pay special attention to the quality of CSR while predicting corporate financial distress.
Retail Managers’ Preparedness to Capture Customers’ Emotions: A New Synergistic Framework to Exploit Unstructured Data with New Analytics
Authors: Pantano Eleonora , Dennis Charles , Alamanos Eleftherios 
Published: July 2021

AbstractAlthough emotions have been investigated within strategic management literature from an internal perspective, managers’ ability and willingness to understand consumers’ emotions, with emphasis on the retail sector, is still a scarcely explored theme in management research. The aim of this paper is to explore the match between the supply of new analytical tools and retail managers’ attitudes towards new tools to capture customers’ emotions. To this end, Study 1 uses machine learning algorithms to develop a new system to analytically detect emotional responses from customers’ static images (considering the exemplar emotions of happiness and sadness), whilst Study 2 consults management decision‐makers to explore the practical utility of such emotion recognition systems, finding a likely demand for a number of applications, albeit tempered by concern for ethical issues. While contributing to the retail management literature with regard to customers’ emotions and big data analytics, the findings also provide a new framework to support retail managers in using new analytics to survive and thrive in difficult times.
Combined association of skeletal muscle mass and grip strength with cardiovascular diseases in patients with type 2 diabetes
Authors: Park Sunmin , Kim Sung‐Hoon , Shin Jang Yel 
Published: July 2021

AbstractBackgroundAppendicular skeletal muscle mass (ASM) and grip strength (GS) have been suggested to be related to cardiovascular diseases (CVDs), but their association with type 2 diabetes (T2D) remains unclear. Therefore, we examined the combined association of ASM and GS with the prevalence of CVD in patients with T2D.MethodsA total of 1230 patients with T2D were recruited and divided into four groups based on the sex‐specific median values of ASM adjusted for body mass index (ASM/BMI; short: SM) and GS: high SM/high GS (HSM/HGS), high SM/low GS (HSM/LGS), low SM/high GS (LSM/HGS), and low SM/low GS (LSM/LGS).ResultsThe LSM/LGS group was older and had higher values of systolic blood pressure, homeostasis model assessment of insulin resistance, waist circumference, and C‐reactive protein but lower high‐density lipoprotein cholesterol concentrations than the HSM/HGS group. After adjusting for potential confounders, the odds ratios (ORs) and 95% CIs for CVD, coronary heart disease (CHD), ischemic stroke, and peripheral arterial disease (PAD) in the LSM/LGS group were 2.90 (1.89‐4.47), 2.39 (1.46‐3.92), 1.77 (0.84‐3.71), and 5.83 (1.58‐21.48), respectively. After adjusting for variable confounders among patients with higher glycosylated hemoglobin (HbA1c) (≥7.1%), the ORs and 95% CIs for CVD and CHD in the LSM/LGS group were 7.27 (3.37‐15.67) and 6.17 (2.65‐14.37), respectively.ConclusionsThe combination of low SM and GS was strongly associated with CVD, CHD, and PAD in patients with T2D, especially in those with higher HbA1c levels.
Perceptions of institutions and social capital accumulation: A social categorization and shared agency‐based approach. Evidence from the Russian Federation
Authors: Sechi Guido , Tatarko Alexander , Šķilters Jurģis 
Published: July 2021

The integration of institutionalist and communitarian views of social capital accumulation is increasingly advocated in order to analyse civil society dynamics, in particular in transitional countries such as former socialist states. The present paper is an attempt at reconciling the two views through a micro level‐focused approach. Such a perspective allows investigating linkages between institutional perception, civic engagement, and trust in society, with the support of social cognition frameworks (social categorization and shared agency). The approach emphasizes the linkages existing between trust toward institutions and perceptions of civic empowerment on the one hand, and civic engagement and trust in society on the other, while also taking into account the role of interpersonal (informal) networking. The analysis, carried out through structural equation modelling, is based on more than 2,000 observations from two federal districts of the Russian Federation. The results show a relevant positive correlation between institutional perception and social capital, and a moderate correlation between bonding (personal networking) and trust in society; on the other hand, civic engagement and trust in society appear to be uncorrelated with each other and with different forms of institutional perception.
Michael Jackson in a Borneo Village; or Autobricolage and Other Acts of Erasure
Authors: Guntarik Olivia 
Published: July 2021

SummaryThis blended genre piece politicizes place through poems, narrative, and musical mash‐ups. It uses ethnography, memoir, and spoken‐word song, a creative technique I call autobricolage. Refusing conventions that create immediate access to meaning, this narrative allows me to present a world in motion and time as non‐linear. Sacred temporality disrupts ordinary instances of time and place and enables the erasure of colonial inscriptions. My returns to and reflections on Borneo life and Dusun kin decolonize and re‐voice a living history. As a metaphor for death, loss, and illness, Michael Jackson is included in my title to express the lure of popular culture in Borneo’s villages. This inclusion shatters the norms constituted in the packaging of cultural heritage and shows how things have a life of their own beyond the West. Acts of collecting stories to reproduce ancestral memories (tangon di gulu gulu) express the fragility and familial in the communal. I am both pilgrim and exile.
Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy
Authors: Smithers B. Mark , Saw Robyn P. M. , Gyorki David E. , Martin Richard C. W. , Atkinson Victoria , Haydon Andrew , Roberts‐Thomson Rachel , Thompson John F. 
Published: July 2021

AbstractAustralia and New Zealand have the highest incidence and mortality rates for melanoma in the world. Local surgery is still the standard treatment of primary cutaneous melanoma, and it is therefore important that surgeons understand the optimal care pathways for patients with melanoma. Accurate staging is critical to ensure a reliable assessment of prognosis and to guide treatment selection. Sentinel node biopsy (SNB) plays an important role in staging and the provision of reliable prognostic estimates for patients with cutaneous melanoma. Patients with stage III melanoma have a substantial risk of disease recurrence following surgery, leading to poor long‐term outcomes. Systemic immunotherapies and targeted therapies, known to be effective for stage IV melanoma, have now also been shown to be effective as adjuvant post‐surgical treatments for resected stage III melanoma. These patients should be made aware of this and preferably managed in an integrated multidisciplinary model of care, involving the surgeon, medical oncologists and radiation oncologists. This review considers the impact of a recent update to the American Joint Committee on Cancer (AJCC) staging system, the role of SNB for patients with high‐risk primary melanoma and recent advances in adjuvant systemic therapies for high‐risk patients.
Short term morphological rescue of the fovea after gene therapy with voretigene neparvovec
Authors: Kortüm Friederike C. , Kempf Melanie , Jung Ronja , Kohl Susanne , Ott Saskia , Kortuem Constanze , Sting Krunoslav , Stingl Katarina 
Published: July 2021

AbstractPurposeLeber congenital amaurosis type 2 (LCA2) and early‐onset severe retinal dystrophy (EOSRD) are linked to visual impairment with nyctalopia and visual acuity reduction in early childhood. In 2017, the first gene therapy voretigene neparvovec (Luxturna™) for patients with LCA and EOSRD cause by bi‐allelic mutations in the RPE65 gene has been approved. Here we report on an example of short‐term change in the foveal morphology after functionally successful gene therapy with voretigene neparvovec in a 15‐year old patient.MethodsThe clinical examinations included best corrected visual acuity (BCVA), spectral domain optical coherence tomography (OCT) and adaptive optics retinal imaging.ResultsDuring follow‐up over a period of 3 months after the treatment, an improvement of the central foveal morphology could be observed in OCT, with a clear demarcation of the external limiting membrane and changes in the photoreceptor mosaic on adaptive optics retinal imaging. These morphological rescue parameters correlated in part with the improvement in foveal‐mediated vision after the treatment and adaptive optics imaging. Although the visual acuity improved only slightly at month 3, objective central cone evaluation with chromatic pupil campimetry showed an increase in the central sensitivity. In daily life, the patient reported her visional experience after the treatment as ‘brighter’.ConclusionRapid changes in the correlates of photoreceptor morphology after successful gene therapy in patients with LCA/EORD can be quantifiable on individual level.
The oldest millet herbal beer in the Europe? The ninth century BCE bronze luxury bucket from Kladina, Czech Republic
Authors: Jílek Jan , Golec Martin , Bednář Petr , Chytráček Miloslav , Vích David , Zavoral Tomáš , Mírová Zuzana , Petr Libor , Kovárník Jaromír , Milo Peter , Kučera Lukáš 
Published: July 2021

AbstractIn 2017, a luxury bronze bucket was discovered near Kladina village in the Czech Republic. The bucket is dated to the ninth century BCE, and it is a unique artefact, having no parallel in Europe. Stylistically, it is a “transition type” dated between the Late Bronze Age (11th–10th century BCE) and the Hallstatt Period (eighth–sixth century BCE). Detailed palynological analysis of verdigris and soil infill of the bucket identified a wide range of pollen grains belonging mainly to herbs, with bitter‐sour properties, and cereals. Subsequent chemical analysis by gas chromatography/mass spectrometry of soil extracts revealed the presence of the compound miliacin that is a chemical marker of millet. Moreover, a starch analysis reveals the presence of enzymatically modified starch grains. These data, with the help of archaeological knowledge, indicate that the original content may have been millet‐based food/beverage with addition of herbs. We suggest that this luxury vessel, given the contents we have identified, was deposited, in the late spring/summer months of the year.
Effect of relationships among clinical mastitis incidence, reproductive performance, and culling rate on the lifetime of dairy cows at Hiroshima University Farm
Authors: Kurokawa Yuzo , Okita Miki , Kubota Hirokazu , Tsumiyama Yoshimasa , Chikamatsu Ichiro , Tanaka Akiyoshi , Obitsu Taketo , Kawamura Kensuke 
Published: July 2021

AbstractFarm managers' decision to cull dairy cows is based on the cows' milk production, history of disorder(s), and reproductive performance, each of which affects dairy cows' lifetime (herd life and productive lifespan). We investigated the relationships among the incidence of clinical mastitis (CM), the reproductive performance, and the culling rate. We also assessed the effects of these relationships on the lifetimes of dairy cows, using the records made before and after the introduction of an automatic milking system (AMS) at Hiroshima University Farm. Milk yield, CM incidence density, and culling rate of dairy cows increased after the AMS introduction. The CM incidence was associated with an elongation of the calving interval in cows with the same parity. CM in the 1st parity might have caused the reductions of the cows' lifetime and their parity at culling. A higher age at first calving (AFC) was associated with an increase in culling rate but did not lead to a significant decrease in lifetime. Investigations of the factors mediating CM in the 1st parity or AFC with CM incidence or culling rate in the later stages might contribute to the control of lifetime of dairy cows.
Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague
Authors: Nguyen Dung , Shaik Jafar Sadik , Tai Guoying , Tiffany Courtney , Perry Caroline , Dumont Etienne , Gardiner David , Barth Aline , Singh Rajendra , Hossain Mohammad 
Published: July 2021

AimsTo develop physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models to predict effective doses of gepotidacin in paediatrics for the treatment of pneumonic plague (Yersinia pestis).MethodsA gepotidacin PBPK model was constructed using a population‐based absorption, distribution, metabolism and excretion simulator, Simcyp®, with physicochemical and in vitro data, optimized with clinical data from a dose‐escalation intravenous (IV) study and a human mass balance study. A PopPK model was developed with pooled PK data from phase 1 studies with IV gepotidacin in healthy adults.ResultsFor both the PopPK and PBPK models, body weight was found to be a key covariate affecting gepotidacin clearance. With PBPK, ~90% of the predicted PK for paediatrics fell between the 5th and 95th percentiles of adult values except for subjects weighing ≤5 kg. PopPK‐simulated paediatric means for Cmax and AUC(0‐τ) were similar to adult exposures across various weight brackets. The proposed dosing regimens were weight‐based for subjects ≤40 kg and fixed‐dose for subjects >40 kg. Comparison of observed and predicted exposures in adults indicated that both PBPK and PopPK models achieved similar AUC and Cmax for a given dose, but the Cmax predictions with PopPK were slightly higher than with PBPK. The two models differed on dose predictions in children <3 months old. The PopPK model may be suboptimal for low age groups due to the absence of maturation characterization of drug‐metabolizing enzymes involved with clearance in adults.ConclusionsBoth PBPK and PopPK approaches can reasonably predict gepotidacin exposures in children.
Clinical efficacy of mebeverine for persistent nocturnal enuresis after orthotopic W‐neobladder
Authors: Hashem Abdelwahab , Abdellutif Mohamed M. , Laymon Mahmoud , Abdullateef Muhamad , Abdelhamid Abdalla , Mosbah Ahmed , Abol‐Enein Hassan 
Published: July 2021

ObjectivesTo investigate the efficacy of mebeverine for nocturnal incontinence in male patients with an ileal orthotopic bladder substitute (OBS).Patients and MethodsA randomised controlled trial was carried out for adult male patients who were nocturnal incontinent. Patients were allocated to receive mebeverine 200 mg or placebo once a day in the evening for 3 months. The primary outcome was to compare the continence status between groups, assessed by the urinary domain of the Bladder Cancer Index (BCI) and pad usage. The secondary outcomes were to assess the safety of mebeverine.ResultsThere were 55 patients in the placebo group and 58 in mebeverine group who completed the follow‐up. The median (interquartile range) interval between OBS surgery and starting treatment was 9 (4–13) years in the placebo group and 9 (6–13) years in the mebeverine group. The mean (SD) 3‐month urinary domain score of the BCI was 70.8 (5.6) and 86.4 (14.2) in the placebo and mebeverine groups, respectively (P < 0.001). At 3 months, 54 (98.2%) and 26 (44.8%) patients required the use of a night‐time pad in the placebo and mebeverine groups, respectively. Mebeverine reduced the risk of pad use by 53.4% (95% confidence interval 40.1–66.6; P < 0.001). Constipation occurred in one (2.1%) and three (5.8%) patients in the placebo and mebeverine groups, respectively; abdominal distention occurred in two (3.8%) of the patients in the mebeverine group (P = 0.25).ConclusionMebeverine decreases night‐time pad use and improves the quality of life in male patients with an ileal OBS and is associated with minimal adverse events.
Approved drugs ezetimibe and disulfiram enhance mitochondrial Ca2+ uptake and suppress cardiac arrhythmogenesis
Authors: Sander Paulina , Feng Michael , Schweitzer Maria K. , Wilting Fabiola , Gutenthaler Sophie M. , Arduino Daniela M. , Fischbach Sandra , Dreizehnter Lisa , Moretti Alessandra , Gudermann Thomas , Perocchi Fabiana , Schredelseker Johann 
Published: July 2021

Background and PurposeTreatment of cardiac arrhythmia remains challenging due to severe side effects of common anti‐arrhythmic drugs. We previously demonstrated that mitochondrial Ca2+ uptake in cardiomyocytes represents a promising new candidate structure for safer drug therapy. However, druggable agonists of mitochondrial Ca2+ uptake suitable for preclinical and clinical studies are still missing.Experimental ApproachHerewe screened 727 compounds with a history of use in human clinical trials in a three‐step screening approach. As a primary screening platform we used a permeabilized HeLa cell‐based mitochondrial Ca2+ uptake assay. Hits were validated in cultured HL‐1 cardiomyocytes and finally tested for anti‐arrhythmic efficacy in three translational models: a Ca2+ overload zebrafish model and cardiomyocytes of both a mouse model for catecholaminergic polymorphic ventricular tachycardia (CPVT) and induced pluripotent stem cell derived cardiomyocytes from a CPVT patient.Key ResultsWe identifiedtwo candidate compounds, the clinically approved drugs ezetimibe and disulfiram, which stimulate SR‐mitochondria Ca2+ transfer at nanomolar concentrations. This is significantly lower compared to the previously described mitochondrial Ca2+ uptake enhancers (MiCUps) efsevin, a gating modifier of the voltage‐dependent anion channel 2, and kaempferol, an agonist of the mitochondrial Ca2+ uniporter. Both substances restored rhythmic cardiac contractions in a zebrafish cardiac arrhythmia model and significantly suppressed arrhythmogenesis in freshly isolated ventricular cardiomyocytes from a CPVT mouse model as well as induced pluripotent stem cell derived cardiomyocytes from a CPVT patient.Conclusion and ImplicationsTaken together we identified ezetimibe and disulfiram as novel MiCUps and efficient suppressors of arrhythmogenesis and as such as, promising candidates for future preclinical and clinical studies.