bluuebunny/crossref_metadata_2025_split huggingface dataset:
K‐L estimator for the linear mixed models: Computation and simulation
Authors: Lukman Adewale F. , Amin Muhammad , Kibria B. M. Golam 
Published: December 2021

AbstractThis study introduces a new biased estimator called the K‐L estimator for the linear mixed model to overcome the effect of multicollinearity. We derived the mean squared error property of the proposed estimator and made a theoretical comparison with other methods. For the assessment of the K‐L estimator, we use the mean squared error criterion as a performance evaluation criterion. Moreover, we defined some shrinkage parameters for the proposed estimator. For numerical evaluation, we use a Monte Carlo simulation study and a real example. The result shows the supremacy of the K‐L estimator as compared to the available methods under certain conditions.
Streamlined Iterative Assembly of Thio‐Oligosaccharides by Aqueous S‐Glycosylation of Diverse Deoxythio Sugars
Authors: Wen Peng , Jia Peijing , Fan Qiuhua , McCarty Bethany J. , Tang Weiping 
Published: December 2021

AbstractA streamlined iterative assembly of thio‐oligosaccharides was developed by aqueous glycosylation. Facile syntheses of various deoxythio sugars with the sulfur on different positions from commercially available starting materials were described. These syntheses featured efficient chemical methods including our recently reported BTM‐catalyzed site‐selective acylation. The resulting deoxythio sugars could then be used for the Ca(OH)2‐promoted protecting group‐free S‐glycosylation in water at room temperature. The aqueous glycosylation reaction proceeded smoothly to afford the corresponding 1,2‐trans S‐glycosides in good yields with high chemo‐ and stereoselectivity. An appropriate choice of protecting groups for the thiol in the glycosyl donor was necessary for the development of iterative synthesis of thio‐oligosaccharides. The aqueous glycosylation was then applied to the synthesis of a trimannoside moiety of N‐linked glycans core region.
The legal restructuring framework in Poland: Does it help indebted enterprises avoid bankruptcy?
Authors: Zaremba Ulyana 
Published: December 2021

AbstractThe purpose of the article is to present the latest research regarding the usefulness of restructuring proceedings in Poland, which enterprises threatened with insolvency or already insolvent may use to avoid bankruptcy. Changes in the legal system in Poland in 2015 were ground‐breaking, as not only the bankruptcy law was amended, but also the legal system was enriched with a new Restructuring Law (in force from 2016). The contribution of this article is threefold. First, the specifics of the four types of restructuring proceedings and the main actions to be carried out during the proceedings are discussed. Second, an analysis of the phenomenon of enterprise restructuring in Poland has been conducted on the basis of statistical data published by the Ministry of Justice. Third, the effects of 533 restructuring proceedings opened against capital companies in the period 2016–2018 have been assessed. The results achieved have allowed for the formulation of initial conclusions on the usefulness of the legal debt restructuring framework in Poland for business entities experiencing temporary financial difficulties.
Shared Genetic Architecture Between Rheumatoid Arthritis and Varying Osteoporotic Phenotypes
Authors: Kasher Melody , Freidin Maxim B , Williams Frances MK , Cherny Stacey S , Malkin Ida , Livshits Gregory 
Published: December 2021

ABSTRACT
Rheumatoid arthritis (RA) and low bone mineral density (BMD), an indicator of osteoporosis (OP), appear epidemiologically associated. Shared genetic factors may explain this association. This study aimed to investigate the presence of pleiotropy to clarify the potential genetic association between RA and OP. We examined BMDs at varying skeletal sites reported in UK Biobank as well as OP fracture acquired from the Genetic Factors for Osteoporosis (GEFOS) Consortium and the TwinsUK study. PRSice-2 was used to assess the potential shared genetic overlap between RA and OP. The presence of pleiotropy was examined using colocalization analysis. PRSice-2 revealed that RA was significantly associated with OP fracture (β = 351.6 ± 83.9, p value = 2.76E-05), total BMD (β = −1763.5 ± 612.8, p = 4.00E-03), spine BMD (β = −919.8 ± 264.6, p value = 5.09E-04), and forearm BMD (β = −66.09 ± 31.40, p value = 3.53E-02). Through colocalization analysis, the same causal genetic variants, associated with both RA and OP, were apparent in 12 genes: PLCL1, BOLL, AC011997.1, TNFAIP3, RP11-158I9.1, CDK6, CHCHD4P2, RP11-505C13.1, PHF19, TRAF1, C5, and C11orf49 with moderate posterior probabilities (&gt;50%). Pleiotropy is involved in the association between RA and OP phenotypes. These findings contribute to the understanding of disease mechanisms and provide insight into possible therapeutic advancements and enhanced screening measures. © 2021 American Society for Bone and Mineral Research (ASBMR).
Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population
Authors: Mai Hanran , Cai Canhong , Lin Kun , Zhang Linyuan , Wang Yishuai , He Menghua , Qu Yanxia , Xu Yufen , Fu Lanyan , Pi Lei , Zhou Huazhong , Zeng Dingke , Che Di , Zuo Liandong 
Published: December 2021

AbstractBackgroundPlenty of studies have indicated that some genetic polymorphisms of the breast cancer which associated with its susceptibility may also be related to the susceptibility of abortion. MIR2052HG plays an important role in the onset and progression of breast cancer by maintaining the level of ERα, but to the best of our knowledge, the correlation between risk of recurrent abortion and MIR2052HG rs3802201 C>G polymorphism is still unclear. Therefore, we conducted this case‐control study to investigate whether MIR2052HG rs3802201 C>G polymorphism is associated with susceptibility of recurrent miscarriage (RM).MethodsWe recruited 392 healthy controls and 248 patients with RM to process this research, the participants were all from southern China, and genotyping was performed by TaqMan method.ResultsOur results showed that there was no evidence indicates the MIR2052HG rs3802201 C>G is related to RM (CG and CC: adjusted OR = 0.970, 95% CI = 0.694–1.355, p = 0.8577; GG and CC: adjusted OR = 0.743, 95% CI = 0.416–1.330, p = 0.3174; dominant model: adjusted OR = 0.925, 95% CI = 0.672–1.272, p = 0.6298; recessive model: adjusted OR = 0.751, 95% CI = 0.430–1.321, p = 0.3233).ConclusionWe verified that the MIR2052HG rs3802201 C>G allele might be uncorrelated to the RM risk, but these findings require further validation in multicenter studies with larger sample size and different ethnicities.
Periprocedural Myocardial Injury in High‐Risk Patients With NSTEMI Pretreated With Ticagrelor for Less or More Than 6 Hours Before PCI
Authors: De Luca Leonardo , Pugliese Marco , Putini Rita Lucia , Natale Enrico , Piazza Vito , Biffani Elisabetta , Petrolati Sandro , Musumeci Francesco , Gabrielli Domenico 
Published: December 2021

AbstractWe assessed the impact on periprocedural myocardial injury of a ticagrelor loading dose given <6 or >6 hours before percutaneous coronary intervention (PCI) in non–ST‐elevation myocardial infarction (NSTEMI) patients at high risk. All consecutive patients pretreated with ticagrelor and undergoing PCI for a high‐risk NSTEMI have been included in the present analysis. Propensity‐score matching was performed to compare the outcomes between patients pretreated with ticagrelor for >6 hours or ≤6 hours. The primary outcome was the rate of periprocedural myocardial injury after PCI. We also recorded clinical outcomes, including major adverse cardiovascular events and major bleedings at 1 month. A total of 1216 patients with NSTEMI were deemed eligible for the study: 481 received a ticagrelor loading dose ≤6 hours (mean time, 4.3 ± 1.2 h) and 735 >6 hours (16.1 ± 8.4 hours) before PCI. Patients pretreated with ticagrelor for >6 hours presented more risk factors and comorbidities compared to others. In patients pretreated with ticagrelor for >6 hours, the rate of periprocedural myocardial injury was significantly lower compared to the other group, in the overall population (19.6% vs 37.8%; P < .0001) and in the matched cohort of 644 patients (18.9% vs 33.5%; P < .0001). The rate of major adverse cardiovascular events and major bleeding events did not differ between the two groups, in both unmatched and matched populations. The present study suggests that ticagrelor pretreatment reduces periprocedural myocardial injury in high‐risk patients with NSTEMI undergoing PCI with expected time intervals >6 hours.
The temporal phase structure of team interaction under asymmetric information distribution: The solution fixation trap
Authors: Sohrab Serena G. , Uitdewilligen Sjir , Waller Mary J. 
Published: December 2021

SummaryOrganizations facing dynamic environments typically use teams of individuals to collect and share information in order to make timely and accurate joint decisions. The mature body of prior research concerning team information processing indicates a consistent bias in team decision‐making under conditions that asymmetrically distribute information across team members; this body of research, however, focuses mainly on identifying significant relationships between static inputs and decision outcomes. As a result, little is known regarding the actual team processes that may influence decision outcomes. We introduce the notion of the temporal phase structure of team behaviors to the asymmetric information distribution research stream and identify relevant phase characteristic variables that show significant differences between lower‐ and higher‐performing teams in a team decision‐making simulation. We find evidence suggesting that higher‐performing teams are more able than other teams to prolong productive discussion of information without falling into a pattern of solution fixation. Finally, we identify specific behaviors that are likely to trigger beneficial and detrimental phase shifts. We close with a discussion of this evidence and suggestions for related future research.
Environmental change since the Last Glacial Maximum: palaeo‐evidence from the Nee Soon Freshwater Swamp Forest, Singapore
Authors: Nguyen Canh Tien Trinh , Moss Patrick , Wasson Robert J. , Stewart Philip , Ziegler Alan D. 
Published: December 2021

AbstractOur examination of pollen, microcharcoal, and sediment material in Nee Soon Freshwater Swamp Forest in Singapore revealed the following regarding its more than 20 000‐year history: (1) the pollen record supports the presence of a savanna corridor in this part of South‐East Asia during the Last Glacial Maximum (LGM); (2) a high abundance of charcoal at depths greater than 1.5 m supports the existence of a dryer climate and/or more frequent fires until about 18 000 cal
bp; (3) missing sedimentary material in the upper 30–40 cm, ranging in age from 64 to 7500 cal
bp, was likely removed during recent construction work in the 1950s; (4) there is evidence of sea‐level influences on the site from the presence of mangroves from 9000 cal
bp to present but it is difficult to determine whether this impacted the site because of the missing sediments; and (5) the low organic carbon content throughout the stratigraphy indicates that the swamp is not a peatland. The results indicate that the forest in this protected area of Singapore developed from a grassland‐dominated landscape after the LGM as the climate warmed and became wetter, and therefore, may not be as resilient to long‐term drought conditions as previously believed. Further, the stratigraphy contains evidence that the swamp and stream system have been highly dynamic, both naturally and in response to anthropogenic disturbance.
Electrical performance of ZrC ceramics
Authors: Schönfeld K. , Trache M. , Martin H.‐P. 
Published: December 2021

AbstractIn the present study it was possible to provide evidence that ZrC ceramics – regarding their electrical‐mechanical and thermal properties – are an attractive substitute for tungsten and molybdenum in the field of refractory materials and heating elements. For this purpose, the heating behavior of ZrC materials was investigated in a specific test stand under high vacuum conditions (10−6 mbar) at temperatures above 2000 °C. In addition, the applicability of ZrC as an electrical heating element was investigated in terms of geometric design and long‐term behavior. Examinations after the heating tests did not reveal any significant changes in the material.
Effect of heat treatment environment on the structural characteristics and microhardness of high velocity oxy‐fuel sprayed tungsten carbide‐cobalt coatings
Authors: Govande A.R. , Katiyar J.K. , Sunil B.R. , Dumpala R. 
Published: December 2021

AbstractIn the present study, tungsten carbide‐cobalt was coated on the austenitic stainless steel using high velocity oxy‐fuel spraying. The as‐deposited coatings were heat treated at 750 °C in air and argon gas environments. Structural characteristics of these coatings were studied using x‐ray diffraction and Raman spectrum analysis. Further, the microhardness of the polished coated samples was also evaluated. The hardness of the coatings was significantly improved after heat treatment in air and argon gas environment. However, the highest hardness was observed with the coatings treated in argon gas environment. The formation of oxide phases such as tungsten trioxide and cobalt tungstate was observed after heat treatment in the air environment, whereas under the argon environment, no oxide phases were observed.
Air pollution and outpatient visits for cardiovascular and cerebrovascular diseases: A time‐series analysis in Luoyang, China
Authors: Guo Hengliang , Wang Mengfei , Wei Haitao , Gong Xiyun , Yang Hong 
Published: December 2021

AbstractPrevious studies have shown that air pollutants have a significant impact on cardiovascular and cerebrovascular diseases (CCD), but these studies have focused more on provincial capitals or large cities. This study was the first time to explore the effects of air pollutants on CCD in Luoyang. In this study, the generalized additive model (GAM) was used to establish a single‐pollutant model, a multi‐pollutant model and stratified modes of age, sex and season to evaluate the effects of PM2.5, PM10, SO2, NO2, CO and O3 on outpatient visits for CCD within a week. The results of the single‐pollutant model showed that PM2.5, PM10, SO2, NO2, CO and O3 all had significant effects on the outpatient visits for CCD with a lag effect. The multi‐pollutant model showed that there might be complex interactions among pollutants. The results of the stratified model showed that there was no significant difference in the effects of different pollutants on different genders and ages, and the results of seasonal stratification showed that PM2.5, PM10, SO2 and CO had a greater influence on the outpatient visits for CCD in spring and summer, while NO2 and O3 had a greater influence on the outpatient visits for CCD in winter and summer, respectively. The results showed that air pollutants significantly affected outpatient visits for CCD, among which NO2 had the greatest influence, and seasonal effects and the combined effects of various pollutants should be considered in strategies for the prevention of CCD.
Quantitative sodium magnetic resonance imaging in food: Addressing sensitivity issues using single quantum chemical shift imaging at high field
Authors: Clerjon Sylvie , El Sabbagh Nour , Pages Guilhem , Traore Amidou , Bonny Jean‐Marie 
Published: December 2021

AbstractAccording to various health organizations, the global consumption of salt is higher than recommended and needs to be reduced. Ideally, this would be achieved without losing the taste of the salt itself. In order to accomplish this goal, both at the industrial and domestic levels, we need to understand the mechanisms that govern the final distribution of salt in food. The in‐silico solutions in use today greatly over‐simplify the real food structure. Measuring the quantity of sodium at the local level is key to understanding sodium distribution. Sodium magnetic resonance imaging (MRI), a non‐destructive approach, is the ideal choice for salt mapping along transformational process. However, the low sensitivity of the sodium nucleus and its short relaxation times make this imaging difficult. In this paper, we show how sodium MRI can be used to highlight salt heterogeneities in food products, provided that the temporal decay is modeled, thus correcting for differences in relaxation speeds. We then propose an abacus which shows the relationship between the signal‐to‐noise ratio of the sodium MRI, the salt concentration, the B0 field, and the spatial and temporal resolutions. This abacus simplifies making the right choices when implementing sodium MRI.
Association of social support, spirituality with psychological factors in Iranian breast cancer survivors: An evidence from a cross‐sectional study
Authors: Hajian‐Tilaki Erfaneh , Hajian‐Tilaki Karimollah , Moslemi Dariush , Godazandeh Gholamali , Firouzbakht Mojgan 
Published: December 2021

AbstractAimsThe aim of this study was to explore the protective role of social support and spirituality in the prevention of depression, anxiety and fatigue severity.DesignIn a cross‐sectional study, 305 women of breast cancer survivors were recruited in the study.MethodsThe participants answered a self‐reported the hospital anxiety and depression scale, fatigue severity scale (FSS), social support and spiritual health questionnaires. The data were analysed using a multiple linear regression model to estimate the adjusted regression coefficients.ResultsA greater proportion of patients had moderate depression (62.9%) and moderate anxiety (67.3%). The higher level of social support was significantly associated with a lesser degree of depression (β=−0.05, p = .001) and anxiety (β=−0.04, p = .001), but there had been no association with the severity of fatigue score, while the association of spiritual health with depression and anxiety was not independently significant. This study highlights the importance of perceived social support in the prevention of depression and anxiety.
Modeling of fiber‐bending stiffness in fiber‐reinforced composites with a dynamic mixed finite element method based on the principle of virtual power
Authors: Kalaimani Iniyan , Dietzsch Julian , Groß Michael 
Published: December 2021

AbstractInvestigating the bending stiffness of fibers in fiber‐reinforced composites for rotor‐dynamical systems which are subjected to dynamical loads are essential in the development of system design. The proposed numerical modeling approach of fiber‐reinforced composites uses a multi‐field mixed finite element formulation based on a dynamic variational approach to perform long‐term dynamic simulations with CPU‐time efficient and increased accurate numerical solutions. To model the bending stiffness of fibers accurately, we extend a Cauchy continuum with higher‐order gradients of the deformation mapping as an independent field in the functional formulation. This extended continuum also takes into account the higher‐order energy contributions including the fiber curvature along with popular proven approaches that efficiently avoid the numerical locking effect of the fibers. The effect of the proposed approach is demonstrated through transient dynamic analysis on a cantilever beam with a hyperelastic, transversely isotropic, polyconvex material behavior. The beam is subjected to bending load with a strong dependence of the overall stiffness on the fiber orientation. The material and conservation properties are analyzed.
Sandwich panels with functionally graded strut‐based lattice cores
Authors: Georges Hussam , Mittelstedt Christian , Becker Wilfried 
Published: December 2021

AbstractDue to their high mechanical performance, sandwich panels are widely utilized in many applications. Among the most frequently used cores in sandwich panels are honeycomb structures. Since the invention of additive manufacturing, new core structures like strut‐based lattices which are not possible by conventional manufacturing processes are also being considered as cores for sandwich panels. Depending on the given boundary conditions and load cases, core struts must transfer different loads. Particularly struts near load introduction points and support points are exposed to high local stresses. In the present study, a graded core is used to reduce the effect of local stress concentration near load introduction points and support points. In the graded core higher loaded areas show a higher relative density. In contrast, low loaded areas represent lower relative density, resulting in a reduction of the core weight and a uniform stress distribution. Only the strut diameters are varied. It is demonstrated that systematic optimization allows a well‐tailored core gradation and some valuable weight reduction.
Building models for coupled thermo elastic problems in different software architectures using a new model exchange format
Authors: Sauerzapf Stefan , Naumann Andreas , Beitelschmidt Michael 
Published: December 2021

AbstractTo reduce the energy consumption of machine tools while preserving the productivity and quality, the deformation caused by thermal loads must be taken into account. Two approaches to reach this goal are the integration of model predictive error correction algorithms into the machine controller and a machine design that mitigates unwanted thermo‐elastic behaviour.Both approaches demand a profound understanding of the machine behaviour under different thermal load scenarios by simulation. The computation of representative distortions requires accurate models of the machine components, relevant physical phenomena and appropriate numerical methods, ranging from adaptive finite element discretization to model order reduction methods. In most cases, these methods and models are developed independently by different scientific groups, whereas the total goal of an improved operation of the machine tool demands the joint knowledge of all teams within the same machine model.This contribution, introduces an open source format for a seamless model exchange between the scientific groups. It bases on the standardized and machine readable JSON format. The JSON scheme comprises of all necessary model information. The main use cases, benefits and drawbacks are outlined. The file structure is briefly described. Design decisions and problems are discussed. After that, a work flow using the new format to calculate the thermal behaviour of a machine tool is shown. Different modelling approaches to calculate the thermal field are compared. Finally the next development steps and further use cases for the format will be outlined.
A holistic vibration analysis of an electric engine including mechanical and electrodynamic interactions
Authors: Koch Sebastian , Duvigneau Fabian , Woschke Elmar 
Published: December 2021

AbstractIn this paper, a method for vibration analysis of electric engines and associated structure is presented. For this purpose, a multi‐body simulation (MBS) is extended in such a way that electromagnetic loads can be considered using the finite element method (FEM). Subsequently, the determined loads lead to an excitation of the structural vibrations and a sound radiation of the engine, which is analyzed at selected operating points. A test rig will be used to validate the implemented method. Finally, different design variations of the engine are evaluated with respect to their acoustic behavior. The developed method is not limited to the presented application, but it can be applied to any system with electric drives.