bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Sistem Informasi Pelayanan Publik Terintegrasi Pada Kecamatan dan Kelurahan (Studi Kasus : Kecamatan Citangkil Kota Cilegon)
Authors: Sudaryono Sudaryono , Sutisna Nanang , Englista Linda Evan 
Published: October 2021

PATEN (Pelayanan Administrasi Terpadu Kecamatan) merupakan pengelolaan pelayanan publik yang diselenggarakan dalam satu tempat di kecamatan, mulai dari proses penerimaan permohonan pelayanan sampai dengan pencetakan dan penyerahan dokumen pelayanan. Hal ini menuntut petugas pelayanan untuk dapat memberikan pelayanan dengan cepat dan tepat. Petugas pelayanan di wilayah Kecamatan Citangkil seringkali melakukan kesalahan penginputan data pemohon ke dalam formulir pelayanan sehingga menyebabkan pemborosan sumber daya seperti kertas dan tinta printer. Selain itu hal ini juga menyebabkan waktu pelayanan menjadi lebih lama. Selain permasalahan tersebut, masih marak oknum yang berperan sebagai ‘Calo’ pelayanan dan praktek ‘pungli’ dalam memberikan pelayanan. Berdasarkan beberapa permasalahan tersebut, Kecamatan Citangkil akhirnya merancang sebuah sistem informasi pelayanan publik terintegrasi pada kecamatan dan kelurahan yang disingkat menjadi SIMPel. SIMPel menggunakan database berbasis NIK sehingga diharapkan mampu mengurangi resiko kesalahan input data pemohon. SIMPel juga disertai dengan QRCode yang dapat digunakan dalam proses validasi dokumen serta sebagai alat pengontrol dalam proses pelayanan untuk mencegah terjadinya ‘pungli’ oleh oknum yang tidak bertanggung jawab. Dalam melakukan Pengembangan SIMPel, peneliti menggunakan metodologi Waterfall Development dan menggunakan metode berorientasi obyek dengan notasi UML dalam perancangannya.
Kata Kunci : Pelayanan Publik, PATEN, Kecamatan, Kelurahan
Penerapan Teorema Bayes Untuk Mendiagnosa Penyakit yang Diakibatkan oleh Bakteri Treponema Pallidum
Authors: Sembiring Nita Sari Br 
Published: October 2021

Bakteri treponema pallidum merupakan suatu bakteri yang dapat menyebabkan penyakit sifilis. Bakteri Treponema Pallidum dapat ditularkan melalui kontak fisik seperti hubungan seksual sehingga mengakibatkan korban terkena penyakit sifilis. Biasanya hanya sedikit penularan melalui kontak bibir, melalui jarum suntik, atau penularan melalui ibu yang mengidap sifilis tiga tahun pertama ke janinnya. Permasalahan yang sering dihadapi oleh masyarakat dari bakteri ini ialah ketidaktahuan masyarakat akan gejala dan penyakit yang diakibatkan oleh bakteri treponema pallidum ini serta proses penyebaran dari bakteri Treponema Pallidum ini. Masyarakat juga banyak yang belum mengetahui bagaimana cara untuk menangani secara dini jika sudah terkena penyakit yang diakibatkan oleh bakteri ini. Pada proses diagnosa dari bakteri Treponema Pallidum ini diperlukan suatu metode probabilitas untuk dapat memberikan tingkat kepercayaan dari hasil diagnosa. Teorema bayes dapat digunakan sebagai metode untuk menentukan tingkat probabilitas dari hasil diagnosa penyakit yang diakibatkan oleh bakteri Treponema Pallidum. Hasil dari penelitian ini ialah mendiagnosa penyakit yang diakibatkan oleh bakteri Treponema Pallidum dengan menggunakan Teorema Bayes.

Kata Kunci: Teorema Bayes, Bakteri Treponema Pallidum, Sifilis.Teorema Bayes
Associação entre hiperuricemia e fatores relacionados à síndrome metabólica em uma população mista da Cidade do Salvador, Bahia, Brasil.
Authors: Silva Joane Matos , Silva Thomas Thássio Rodrigues de Araújo , Fatal Lílian Brito da Silva , Silva Caroline Ferraz , Meira Débora da Silva , Lima Claubert Radamés Oliveira Coutinho de , Santos Luama Araujo dos , Brandão Najara Amaral , Sacramento Joselita Moura , Bordallo Carine de Oliveira Sousa , Rios Domingos Lázaro Souza , Araújo Edilene Maria Queiroz 
Published: October 2021

A hiperuricemia é comumente observada nos pacientes com síndrome metabólica (SM) e ambas estão relacionadas ao risco de desenvolvimento de doenças cardiovasculares. Assim, o presente estudo tem como objetivo verificar se há associação entre hiperuricemia e fatores relacionados à SM em uma população mista da cidade do Salvador, Bahia, Brasil. Método: Estudo transversal, com 610 pacientes, adultos e idosos, de ambos os sexos, com SM e atendidos numa clínica escola de nutrição entre os anos de 2013-2018. Para a análise dos resultados, realizou-se a avaliação descritiva dos dados sociodemográficos, teste Qui-Quadrado de Pearson e teste exato de Fisher. Foram considerados resultados significativos p≤ 0,05. Resultados: A prevalência de hiperuricemia foi de 14% (n=79). Houve associação entre hiperuricemia e hipertensão (p=0,035) e hiperuricemia e hipertrigliceridemia (p=0,002), porém não houve associação significante entre hiperuricemia e hiperglicemia (p= 0,56) e baixa concentração de lipoproteína de alta densidade (p=0,90), bem como com o índice de massa corporal (p=0,165) e proteína C reativa (p=0,801). Conclusão: Houve associação significativa entre hiperuricemia e cofatores da síndrome metabólica.
Impacto dos tratamentos de fissuras labiopalatinas na qualidade de vida: avaliação pelo CLEFT-Q
Authors: Soares Maria Sueli Marques , Barros Mariana Silva , Albuquerque Ana Carolina Lyra de , Lacerda Rosa Helena Wanderley , Vieira Alexandre Rezende 
Published: October 2021

Introdução: A perspectiva do paciente com fissura labiopalatina (FLP) é importante para avaliar resultados obtidos nos tratamentos, podendo contribuir para melhor qualidade de vida. Objetivos: Através do CLEFT-Q, avaliar a influência do tratamento na qualidade de vida do paciente. Métodos: Estudo transversal observacional, com 100 indivíduos com FLP, os quais responderam o CLEFT-Q. Resultados: A média de idade dos participantes foi 16±4,9 anos. O tipo de FLP mais frequente foi o transforame, com 85%. Os tratamentos realizados foram: queiloplastia, palatoplastia, enxerto ósseo, rinoplastia e tratamento ortodôntico. Os escores CLEFT-Q mais baixos foram nas Escalas de Aparência, relacionados à aparência do nariz e narinas e, os maiores foram nas Escalas de Qualidade de vida, relacionados a aspectos psicológico e escolar. Houve correlação estatisticamente significante entre os tratamentos e pelo menos uma Escala nos domínios Aparência, Qualidade de vida e Função facial, exceto para rinoplastia. O tratamento ortodôntico teve correlação negativa com todos os domínios, com associação estatisticamente significante nas Escalas face, narinas, dentes, lábios, dificuldade da fala, escolar, social e fala, exceto para nariz, psicológico e comer/beber. A escala fala teve correlação estatisticamente significante com palatoplastia, enxerto ósseo e tratamento ortodôntico e, a Escala comer/beber teve com enxerto ósseo. Conclusões: Pacientes com FLP sentem insatisfação com sua aparência facial, especialmente, quanto ao nariz, narinas e dentes. Os tratamentos impactaram na percepção do paciente quanto a aparência, qualidade de vida relacionada à saúde e função facial. A queiloplastia e o enxerto ósseo impactaram positivamente na qualidade de vida do paciente com FLP.
Adesão ao tratamento antirretroviral e supressão viral entre pacientes do Hospital de Clínicas da Unicamp: buscando a meta UNAIDS 90-90-90
Authors: Melo Márcio Cristiano de , Polillo Filho Flávio Eugenio , Moreno Flávia Fernanda , Bühl Carolina Neves , Donalisio Maria Rita 
Published: October 2021

Objetivo: verificar a adesão ao tratamento antirretroviral e a supressão viral, segundo variáveis demográficas, clínicas e laboratoriais em pacientes atendidos no ambulatório de HIV/AIS do Hospital de Clínicas da Unicamp em 2016. Método: estudo transversal sobre o perfil demográfico, epidemiológico e clínico dos pacientes atendidos no Ambulatório de Infectologia no Hospital Dia da Universidade Estadual de Campinas para avaliar a adesão ao tratamento antirretroviral e eventuais eventos adversos registrados no ano de 2016. Resultados: dos 339 prontuários amostrados de Pessoas Vivendo com HIV e aids (PVHA), 278 (82,0%) com uso regular de antirretrovirais e 293 (86,4%) com carga viral indetectável (<40 cópias/mL). No modelo logístico múltiplo a idade, intercorrências clínicas e efeitos colaterais de medicamentos foram associados à menor adesão à tratamento antirretroviral. A supressão viral foi maior entre os homens, com mais idade e menor tempo de diagnóstico; e menos frequente nos pacientes com intercorrências clínicas e efeitos adversos da medicação. Conclusão: uma maior integração entre serviços de saúde pode facilitar a aderência de PVHA sem seguimento clínico. O manejo clínico de complicações e eventos adversos de medicamentos são relevantes para a adesão ao tratamento e à supressão viral em pacientes que frequentam os serviços.
Organic onion biofortification using microalgae and humic acid
Authors: Gemin Luiz Gabriel , Lara Gabriel Bocchetti de , Mógor Átila Francisco , Mógor Gilda , Queiroz Christiane de 
Published: October 2021

Biofortification can be understood as a strategy to raise nutrients levels in vegetables edible structures, which can positively interfere in human diet. Biofertilizers are an interesting option in alternative production systems, as they can increase food nutritional quality and contribute to plant development, while aiding environment sustainability as natural products. The use of microalgae and humic acid as biofertilizers points to improvements in nutrients and biomolecules content in plants, however, their combined application is still unexplored. In that scenario, it was carried a study with onions about the influence of applications via root immersion in microalgae Scenedesmus subspicatus (Sc) and humic acid (HA) solutions, analyzing possible alterations of macro and micronutrients, total sugars, reducing sugar, free total amino acids, , total soluble solids, soluble proteins and antioxidant capacity in the bulbs. Treatments consisted of one minute seedlings roots immersion from two onion cultivars in solutions containing microalgae and humic acid, and then transplanted to organic system field. There were used three concentrations: control, 0.3 g L-1 Sc + 0.3 g L-1 HA (3SH) and 0.6 g L-1 Sc + 0.6 g L-1 HA (6SH). Results show that the treatments with microalgae with humic acid association were able to increase the content of N, carbohydrates and soluble proteins, also elevating antioxidant activity in onion bulbs.
Kebijakan Penanganan Pengungsi Luar Negeri di Indonesia
Authors: Utami Penny Naluria , Nugroho Okky Chahyo , Situmorang Donny Michael 
Published: October 2021

Pengungsi terjadi karena adanya keadaan yang memburuk dalam ranah politik, ekonomi, dan sosial suatu negara tersebut sehingga memaksa masyarakatnya untuk pergi meninggalkan negara tersebut dan mencari tempat berlindung yang lebih aman di negara lain. Permasalahan yang diangkat mengenai Implementasi Peraturan Presiden Nomor 125 Tahun 2016 tentang Penanganan Pengungsi dari Luar Negeri dan hambatannya. Untuk mengidentifikasi permasalahan yang dihadapi dalam pelaksanaan struktural dan teknis, serta menawarkan solusi atau alternatif penyelesaian atas permasalahan yang dihadapi dituangkan dalam rekomendasi. Deskriptif dengan menggunakan pendekatan kualitatif agar dapat menjelaskan proses, para pihak yang terlibat serta konteks implementasi Peraturan Presiden Penanganan Pengungsi dari Luar Negeri di lapangan. Implementasinya dibuktikan dengan dibentuknya Peraturan Presiden 125 Tahun 2016. Akan tetapi, setahun lebih Peraturan Presiden diundangkan, masih ditemukan sejumlah tantangan dan permasalahan. Ada empat faktor yang merupakan syarat utama keberhasilan proses implementasi, yaitu: perlu adanya komunikasi antar antar tugas dan fungsi Desk Penanganan Pengungsi, sarana dan infrastruktur penampungan yang sesuai dengan Peraturan Presiden. Sumber daya manusia sertaanggaran tiap-tiap stakeholder, Tugas dan fungsi tiap-tiap desk yang diterjemahkan kedalam aturan pelaksana dari Peraturan Presiden Penanganan Pengungsi dari Luar Negeri.
Kata Kunci: Implementasi, Penanganan, Pengungsi, Luar Negeri.
Penumbuh-kembangan Inovasi Melalui Laboratorium Inovasi Bagi Pemerintah Daerah di Indonesia
Authors: Srimarchea Desak Widhiatuti , Aziza Tri Noor 
Published: October 2021

Sejak reformasi tahun 1998 terjadi perubahan dalam berdemokrasi, dari sentralistik menjadi desentralistik serta adanya otonomi daerah yang memberikan kebebasan kepada setiap daerah untuk mengelola daerahnya sendiri. kebebasan ini disertai dengan tanggung jawab bahwa Pemerintah daerah harus memberikan dan meningkatkan pelayanan kepada masyarakat. karenanya diperlukan terobosan salah satunya dengan inovasi. Lembaga Administrasi Negara berupaya mengakselerasi penumbuh-kembangan inovasi tata kelola pemerintahan di lingkungan pemerintah daerah melalui Program Nasional Laboratorium Inovasi dengan cara pendampingan inovasi pada pemerintah daerah menggunakan instrumen 5D (Drum up, Diagnose, Design, Deliver dan Display). Lokus Laboratorium Inovasi yang dijadikan sebagai bahan penelitian ada dua yaitu Kabupaten Tanah Bumbu di Provinsi Kalimantan Selatan dan Kabupaten Kotawaringin di Provinsi Kalimantan Kalimantan Tengah. Dengan metode analisis deskriptif melalui studi kepustakaan. Kajian ini ingin melihat kemanfaatan yang diberikan laboratorium inovasi dalam hal penumbuh-kembangan inovasi di daerah. Hasil analisis menunjukkan bahwa melalui pendampingan laboratorium inovasi, daerah mendapatkan manfaat yaitu terbukanya cakrawala pemikiran aparatur, serta mengubah cara pandang masyarakat terhadap kinerja aparat pemerintah dan menumbuhkan trust masyarakat terhadap pemerintah daerah.
Kata kunci: inovasi; pemerintah daerah; laboratorium inovasi
A Novel Overall Survival Prediction Signature Based on Cancer Stem Cell-Related Genes in Osteosarcoma
Authors: Xiao Bo , Liu Liyan , Chen Zhuoyuan , Li Aoyu , Xia Yu , Wang Pingxiao , Xiang Cheng , Zeng Yi , Li Hui 
Published: October 2021

Background: Osteosarcoma is the most general bone malignancy that mostly affects children and adolescents. Numerous stem cell-related genes have been founded in distinct forms of cancer. This study aimed at identifying a stem cell-related gene model for the expected assessment of the prognosis of osteosarcoma patients.Methods: We obtained the genes expression data and relevant clinical materials from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases. We identified differentially expressed genes (DEGs) from the GEO dataset, whereas prognostic stem cell-related genes were obtained from the TARGET database. Subsequently, univariate, LASSO and multivariate Cox regression analyses were applied to establish the stem cell-related signature. Finally, the prognostic value of the signature was validated in the GEO dataset.Results: Twenty-five genes were prognostic ferroptosis-related DEGs. Consequently, we identified eight stem cell-related genes as a signature of prognosis of osteosarcoma patients. Then, the Kaplan–Meier (K-M) curve, the AUC value of ROC, and Cox regression analysis verified that the eight stem cell-related gene model were a new and substantial prognostic marker independent of other clinical traits. Moreover, the nomogram on the foundation of risk score and other clinical traits was established for predicting the survival rate of osteosarcoma patients. Biological function analyses displayed that tumor related pathways were affluent.Conclusion: The expression level of stem cell-related genes offers novel prognostic markers as well as underlying therapeutic targets for the therapy and prevention of osteosarcoma.
Lateral Flow Immunoassay for the Detection of Panton-Valentine Leukocidin in Staphylococcus aureus From Skin and Soft Tissue Infections in the United Arab Emirates
Authors: Senok Abiola , Monecke Stefan , Nassar Rania , Celiloglu Handan , Thyagarajan Sreeraj , Müller Elke , Ehricht Ralf 
Published: October 2021

IntroductionPanton Valentine leukocidin (PVL) is a virulence factor which is associated with methicillin sensitive and resistant Staphylococcus aureus (MSSA/MRSA) causing skin and soft tissue infections (SSTI). This study aimed to evaluate a novel lateral flow immunoassay (LFI) for PVL detection in S. aureus cultures and to describe their genotypic characterization.MethodsThe study was carried out from January-August 2020 in Dubai, United Arab Emirates. S. aureus isolates associated with SSTI were tested for PVL detection using LFI. DNA microarray-based assays were used for molecular characterization including detection of pvl genes.ResultsOne-hundred thirty-five patients with a clinical diagnosis of SSTIs were recruited. Sixty-six patients received antibiotics, mostly beta lactams (n=36) and topical fusidic acid (n=15). One-hundred twenty-nine isolates (MRSA: n=43; MSSA: n=86) were tested by LFI and DNA microarrays. All 76 (58.9%) isolates which were unambiguously negative for the PVL in LFI were negative for pvl genes using the DNA microarray. All the LFI PVL positive isolates (n=53) had pvl genes detected. This translates into 100% each for sensitivity, specificity, positive and negative predictive values for the LFI. The LFI typically takes about 15 min inclusive of a 10 min incubation period. Predominant S. aureus clonal complexes (CC) were CC30 (n=18), CC22 (n=13), CC5 (n=12), CC1 (n=11), CC152 (n=8), CC15 (n=7); CC97 (n=7); CC8 and CC20 (n=6 each). Among MRSA, the proportion of pvl-positives (35/43; 81%) was higher than among MSSA (n/N=18/86; 21%). The fusidic acid resistance gene fusC was detected in 14 MRSA (33%) compared to 8 MSSA (9%). A co-carriage of fusC and pvl genes was present in 7 MRSA and in one MSSA.ConclusionLFI shows excellent diagnostic accuracy indices for rapid identification of PVL in MSSA/MRSA in a setting with high prevalence of pvl+ve strains. The high occurrence of pvl and fusC genes in MRSA strains causing SSTI is of concern and needs constant surveillance.
Application of a Novel Common-Iliac-Artery Skirt Technology (CST) in Treating Challenge Aorto-Iliac or Isolated Iliac Artery Aneurysms
Authors: Wang Lunchang , Shu Chang , Li Quanming , Li Ming , He Hao , Li Xin , Shi Yin , Qiu Jian , Wang Tun , Yang Chenzi , Wang Mo , Li Jiehua , Wang Hui , Sun Likun 
Published: October 2021

Purpose: To report a novel common-iliac-artery skirt technology (CST) in treating challenge iliac artery aneurysms.Methods: When required healthy landing zone of common iliac artery (CIA) is not available, CST is a strategy to exclude the internal iliac artery (IIA) and prevent IIA reflux without need of embolization. Patients who received endovascular aneurysm repair (EVAR) in our center from 2014 to 2020 were retrospectively screened, and patients treated with CST or with IIA embolization (IIAE) were enrolled.Results: After retrospective screen of 524 EVAR patients, 39 CST patients, 26 IIAE patients, and 7 CST + IIAE patients were enrolled in this study. CST group suggested to have more aged, hyperlipemia, and smoking patients than IIAE group. Two groups had comparable maximal diameter of abdominal aorta (AA), CIA, EIA, but larger diameter of IIA (CST 19.82 ± 2.281 vs. IIAE 27.82 ± 3.401, p = 0.048), and CIA bifurcation (CST 25.01 ± 1.316 vs. IIAE 29.76 ± 2.775, p = 0.087) was found in IIAE group. Anatomy of 79.5% of CST patients and 92.3% of IIAE patients (p = 0.293) was not suitable for potential use of iliac branch device. CST group had significant shorter surgery time (CST 97.42 ± 3.891 vs. IIAE 141.0 ± 8.010, p &lt; 0.001), shorter hospital stay (CST 15.35 ± 0.873 vs. IIAE 19.32 ± 1.067, p = 0.009), lower in-hospital [CST 0% (0/39) vs. IIAE 11.5% (3/26), p = 0.059] and 1-year follow-up stent related MAEs [CST 6.7% (2/30) vs. IIAE 28.6% (6/21), p = 0.052], but comparable mortality and stent related MAEs for all-cohort follow-up analysis comparing to IIAE group. In our study, a lower in-hospital buttock claudication (BC) rate for CST (CST 20.5% vs. IIAE 46.2%, p = 0.053) and a comparable erectile dysfunction (ED) rate (CST 10.3% vs. IIAE 23.1%, p = 0.352) were found between CST and IIAE groups. After 1 year, both groups had about one third relief of BC symptoms [CST 33.3% (4/12) vs. IIAE 30.7% (4/13), p = 1.000]. Subgroup analysis of 14 patents concomitant with IIA aneurysm in CST group and the 7 CST + IIAE patients were carried out, and no difference was found in mortality, stent MAEs, sac dilation, or reintervention rate. Last, illustration of seven typical CST cases was presented.Conclusion: In selected cases, the CST is a safe, feasible-and-effective choose in treating challenge iliac artery aneurysms and preventing IIA endoleak.
Eruption Sequences and Characteristics of Weizhou Island Volcano, Guangxi Province, South of China
Authors: Yu Hongmei , Yang Wenjian , Zhao Bo , Chen Zhengquan , Zhou Bin , Nie Guanjun , Luo Hao 
Published: October 2021

Weizhou island, located in the north margin of the South China Sea (SCS), is characterized by multi-stage volcanism, several eruption styles and eruption craters, and is also the youngest Quaternary volcanic island in China. An eruption on this island may pose high risk to life and property. However, the eruptive history of Weizhou island, the craters number and location, and their eruptive sequence and characteristics are still being debated, which are important for potential volcanic hazard assessment. In the present study, field surveys, 40Ar/39Ar and 14C geochronological studies and whole rock composition analysis of volcanic rock are used to investigate the eruption sequences associated with Weizhou island and the characteristics of each period. Four volcanoes were discovered at Henglushan, Hengling, Nanwan and Daling. The Henglushan and Hengling volcanoes were produced by early weak explosive and late effusive eruptions, and lavas from these volcanoes represent the foundation of island. Conversely, the Nanwan and Daling volcanoes are linked to multiple explosive eruption phases, with hydromagmatic eruptions in the first and last phase and a magmatic explosive eruption in the second phase. The pyroclastic density currents (PDCs) deposits of the Nanwan and Daling volcanoes virtually cover the entire island. Volcanic activity in Weizhou island started in Early Pleistocene and ended in Late Pleistocene. This can be divided into the following distinct periods: 1,420–1,260, 870–740, 600–480, 283–222 ka, and 33.7–13 ka. The first four periods were dominated by effusive eruptions associated with the Henglushan and Hengling volcanoes, which peaked between 870 and 740 ka. After this period, explosive eruptions began at around 33.7 ka because of magma–water interactions. These explosive eruptions then created the Nanwan and Daling volcanoes. Early effusive lava flows in Weizhou island are characterized by basaltic compositions and are linked with a small amount of fractional crystallization. Magmas in later eruptions contained slightly lower SiO2 and involved some basanite. Fractional crystallization was also less pronounced in these lavas because of their rapid ascent.