bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute cardiotoxicity following 'poppy seed tea' consumption
Authors: Tan Y. P. A. , Alexander P. D. G. , Knowles S. 
Published: August 2021

SummaryInsect damage to, and sub‐optimal harvesting practices of the Papaver somniferum poppy are associated with contamination of its seeds with opium alkaloids. Consumption of poppy seeds has been linked to opium‐like overdose symptoms, such as reduced consciousness and respiratory depression. However, acute cardiotoxicity secondary to ingestion of contaminated poppy seeds has not been reported previously. We report a case of a 21‐year‐old man who presented with severe biventricular dysfunction and cardiogenic shock following consumption of homemade poppy seed tea. We highlight the importance of prompt recognition of the myocardial effects of opiates along with the more common respiratory and neurological effects. In this case, the acute cardiotoxicity was fully reversed with high‐dose naloxone, milrinone and noradrenaline. In addition, we recommend offering high‐level care due to the possibility that specialist cardiac services may be required. Ergo, early transfer to an appropriate centre is recommended.
Microwave absorption and roasting characteristics of zinc sulfide concentrate
Authors: Liu Chenhui , Zhu Xiongjin , Zhang Mengping , Xia Zhengqian , Chen Minghong , Zhang Libo 
Published: August 2021

AbstractA novel microwave roasting technology for formation of ZnO from zinc sulfide concentrate is presented. The dielectric properties and thermal behaviors of zinc sulfide concentrate and ZnS, CaO, MgO, ZnO, FeS, and ZnFe2O4, covering a temperature range of 25 to 1000°C at 2.45 GHz, are systematically investigated. The main microwave absorbing compounds are FeS and ZnS, while compounds like CaO, MgO, and SiO2 and other gangue exhibit poor absorbing properties. The sulfide concentrate temperature increase was divided into four stages, consistent with the dielectric properties. The morphology, phase and element contents of roasted were assessed covering the effect of roasting temperature, holding time, and particle size by SEM, XRD, and XRF. The optimal process conditions are roasting temperature 700°C, holding time 120 min, and the particle size less than 200 mesh. Microwave roasting mechanism shows microwave heat minerals (ZnS and FeS) selectively without heating gangue minerals (CaO, MgO, and SiO2), a significant temperature gradient develops between minerals. Thermal stress cause cracks effectively promote the dissociation of the monomers of useful minerals, increasing the interfacial area with O2, promoting the rate of desulfurization reaction. The work highlights harnessing microwave roasting as an effective and environmentally benign technology compared to conventional furnace technologies.
Poly (lactic acid)/D‐limonene/ZnO bio‐nanocompositeswith antimicrobial properties
Authors: Sepúlveda Francesca Antonella , Rivera Francisca , Loyo Carlos , Canales Daniel , Moreno‐Serna Viviana , Benavente Rosario , Rivas Lina María , Ulloa María Teresa , Gil‐Castell Oscar , Ribes‐Greus Amparo , Ortiz J. Andrés , Zapata Paula A. 
Published: August 2021

AbstractAntimicrobial films of poly (lactic acid) (PLA)/D‐limonene/zinc oxide (ZnO)‐based bio‐nanocomposites were prepared via melt compounding and subsequent thermocompression. D‐limonene was incorporated at concentrations of 10 or 20 wt%, and ZnO pure nanoparticles and those organically modified with oleic acid (O‐ZnO), with an average diameter of 13.5 nm, were included at concentrations of 3, 5, and 8 wt%. The plasticizing effect of D‐Limonene was corroborated by a decrease in the glass transition temperature compared to pure PLA. The presence of ZnO and O‐ZnO in the PLA matrix promoted a slight increase in the degree of crystallinity due to its nucleant performance. Although ZnO and O‐ZnO induced lower thermal stability and slightly decreased microhardness in the composites, excellent antimicrobial performance was demonstrated. Both ZnO and O‐ZnO nanocomposites reached 99.9% of effectiveness for nanoparticles content above 5 wt%, regardless of the source of irradiation, D‐limonene concentration, and nanoparticle modification. Therefore, these bio‐nanocomposites will allow for future advances in sustainable antimicrobial materials for the medical or food packaging fields.
Investigation of thermal and solar properties of perlite coated woven fabrics
Authors: Manasoglu Gizem , Kanik Mehmet 
Published: August 2021

AbstractIn this study, thermal insulation and solar properties of polyester woven fabrics which were coated with micronized perlite having three different particle sizes (10–38, 50–63, and 100–150 μm) at four different concentrations (20, 40, 60, and 80 g/kg) were investigated. The coating process was performed according to the knife‐over‐roll method. Thermal measurements were carried out with two different principles to evaluate contact and radiant heat transfer according to JIS R 2618 (testing method for thermal conductivity of insulating fire bricks by hot wire) and EN ISO 6942 (protective clothing‐protection against heat and fire‐method of test: evaluation of materials and material assemblies when exposed to a source of radiant heat), respectively. Perlite coating enhanced the thermal insulation property of fabrics. The lowest thermal conductivity coefficient and heat transmission factor (0.088 W/mK and 26.83%) values were obtained at the maximum concentration with the biggest size perlite. With the increasing perlite concentration, solar transmittance values decreased for all particle sizes while solar reflectance values increased.
Insight into the role of free volume in irradiation resistance to discoloration of lead‐containing plexiglass
Authors: Zhang Yujuan , Chen Zhiyuan , Zhao Rui , Wang Ke , Wu Defeng , Wang Chunhong , Zhang Ming 
Published: August 2021

AbstractLead‐containing plexiglass is prepared successfully via copolymerization of lead‐methacrylate (Pb(MAA)2 and the acrylic monomer such as methyl methacrylate, methyl acrylate, ethyl acrylate, and butyl acrylate. The results show that as‐prepared plexiglass has good photons shielding performance and resistance to the discoloration induced by radiation (10 kGy γ‐ray), and the alteration of shielding performance can be well described by the Monte Carlo Code simulations (MCNP5). Using two plasticized systems, the external‐plasticized one with various n‐octanoic acid concentrations and the internal‐plasticized one with different acrylic monomer, as the target samples, it is found that free volume plays dominant role in the irradiation resistance via the positron annihilation lifetime spectroscopy and electron paramagnetic resonance characterizations. The larger the free volume, the greater the quenching probability of free radicals during irradiation. Because the primary type of radiation‐induced color centers are annealable color centers, the effect of annealing of irradiation‐induced discoloration of lead‐containing plexiglass is remarkable. Differing from common treatments of improving irradiation resistance, the increased free volume via plasticization gives plexiglass good resistance to discoloration. This study discloses valuable information around improving irradiation shielding performance and resistance to the radiation‐induced discoloration for the plexiglass‐based materials.
Chemically induced strengthening of curdlan alkylcarbamate thermoplastics
Authors: Ozawa Itsuki , Kawashima Hidehisa , Kijima Masashi 
Published: August 2021

AbstractCurdlan alkylcarbamate (CrdC) with a degree of substitution (DS) of ~2 was chemically modified via postesterification using carboxylic anhydride at a residual OH. Fully substituted mixed esters of curdlan carbamate/carboxylate (CrdCE) (DS = 3) with carbamate hydrogen bonding ability were obtained in high yields (>80%). Owing to replacing the residual OH with alkanoates, the glass transition temperature of CrdCE was lower than that of the corresponding CrdC. All the CrdCE displayed a greater deformability evaluated by elongation at break, being more remarkable when introducing longer esters (almost two times higher than the unmodified CrdC) than shorter esters (1.4 times higher). On the other hand, the effect on both Young's modulus and tensile strength depended on the length of the esters, observing an increase on both parameters when using shorter esters (19% and 17% higher, respectively), and a decrease for longer esters (33% and 6% lower, respectively). Thus, it was established that the physical properties of the thermoplastic CrdC could be controlled by modifying the residual OH with an appropriate ester group.
The imperative for scientific societies to change the face of academia: Recommendations for immediate action
Authors: Carroll Melissa A. , Boynes Shawn , Jerome‐Majewska Loydie A. , Topp Kimberly S. 
Published: August 2021

AbstractAs organizations that facilitate collaboration and communication, scientific societies have an opportunity, and a responsibility, to drive inclusion, diversity, equity, and accessibility in science in academia. The American Association for Anatomy (AAA), with its expressed and practiced culture of engagement, can serve as a model of best practice for other professional associations working to become more inclusive of individuals from historically underrepresented groups. In this publication, we acknowledge anatomy's exclusionary past, describe the present face of science in academia, and provide recommendations for societies, including the AAA, to accelerate change in academia. We are advocating for scientific societies to investigate inequities and revise practices for inclusivity; develop and empower underrepresented minority leadership; and commit resources in a sustained manner as an investment in underrepresented scientists who bring diverse perspectives and lived experiences to science in academia.
Whose relevance? Web search engines as multisided relevance machines
Authors: Sundin Olof , Lewandowski Dirk , Haider Jutta 
Published: August 2021

AbstractThis opinion piece takes Google's response to the so‐called COVID‐19 infodemic, as a starting point to argue for the need to consider societal relevance as a complement to other types of relevance. The authors maintain that if information science wants to be a discipline at the forefront of research on relevance, search engines, and their use, then the information science research community needs to address itself to the challenges and conditions that commercial search engines create in. The article concludes with a tentative list of related research topics.
Electrochemical Fluoridation of Manganese Oxide by Perfluorinated‐Gas Conversion for Lithium‐Ion Cathodes
Authors: Gao Haining , He Mingfu , Guo Rui , Gallant Betar M. 
Published: August 2021

AbstractFluoridation of Lithium‐ion (Li‐ion) cathodes is of growing interest for high‐capacity Li+ storage materials, but well‐controlled fluoridation processes are elusive. We investigated an electrochemical methodology to grow lithium fluoride (LiF) by reduction of perfluorinated gas onto metal oxides (MO), which then forms M−O−F by splitting of LiF upon charge, using MnO as an example target phase. Unlike current methods where particle size <10 nm is necessary for high MnO utilization (subsequent discharge/lithiation capacity), owing to the nano‐crystallinity and intimate contact of electrochemically‐grown LiF, high MnO utilization (∼0.9 e−/MnO, 340 mAh gMnO−1) is achieved with large MnO particle size (∼400 nm), exceeding comparable MnO/LiF systems reported to date. Additionally, incorporation of perfluorinated‐gas additive benefits cycling, with capacity of ∼270 mAh gMnO−1 retained after 20 cycles. This work demonstrates the opportunity for electrochemically driven fluoridation to achieve high capacities with larger particle sizes needed to bring oxyfluorides closer to practical reality.
Liquid–liquid phase separation drives the β‐catenin destruction complex formation
Authors: Shi Qiaoni , Kang Kexin , Chen Ye‐Guang 
Published: August 2021

AbstractThe intracellular multiprotein complex β‐catenin destruction complex plays a key role in Wnt/β‐catenin signaling. Wnt stimulation induces the assembly of the receptor‐associated signalosome and the inactivation of the destruction complex, leading to β‐catenin accumulation and transcriptional activation of the target genes. The core components of the destruction complex include Axin, APC, GSK3β, CK1α and other proteins. Recent studies demonstrated that Axin and APC undergo liquid–liquid phase separation (LLPS), which is critical for their function to regulate Wnt/β‐catenin signaling. Here, we discuss the possible roles of LLPS in Wnt/β‐catenin signaling and regulation of Axin LLPS by post‐translational modifications.
Promising effects of gingerol against toxins: A review article
Authors: Yahyazadeh Roghayeh , Baradaran Rahimi Vafa , Yahyazadeh Ahmad , Mohajeri Seyed Ahmad , Askari Vahid Reza 
Published: August 2021

AbstractGinger is a medicinal and valuable culinary plant. Gingerols, as an active constituent in the fresh ginger rhizomes ofZingiber officinale, exhibit several promising pharmacological properties. This comprehensive literature review was performed to assess gingerol's protective and therapeutic efficacy against the various chemical, natural, and radiational stimuli. Another objective of this study was to investigate the mechanism of anti‐inflammatory, antioxidant, and antiapoptotic properties of gingerol. It should be noted that the data were gathered from in vivo and in vitro experimental studies. Gingerols can exert their protective activity through different mechanisms and cell signaling pathways. For example, these are mitogen‐activated protein kinase (MAPK), nuclear factor‐kappa B (NF‐kB), Wnt/β‐catenin, nuclear factor erythroid 2‐related factor 2/antioxidant response element (Nrf2/ARE), transforming growth factor beta1/Smad3 (TGF‐β1/Smad3), and extracellular signal‐related kinase/cAMP‐response element‐binding protein (ERK/CREB). We hope that more researchers can benefit from this review to conduct preclinical and clinical studies, treat cancer, inflammation, and attenuate the side effects of drugs and industrial pollutants.
Identification and analysis of sugar transporters capable of co‐transporting glucose and xylose simultaneously
Authors: Kuanyshev Nurzhan , Deewan Anshu , Jagtap Sujit Sadashiv , Liu Jingjing , Selvam Balaji , Chen Li‐Qing , Shukla Diwakar , Rao Christopher V. , Jin Yong‐Su 
Published: August 2021

AbstractSimultaneous co‐fermentation of glucose and xylose is a key desired trait of engineered Saccharomyces cerevisiae for efficient and rapid production of biofuels and chemicals. However, glucose strongly inhibits xylose transport by endogenous hexose transporters of S. cerevisiae. We identified structurally distant sugar transporters (Lipomyces starkeyi LST1_205437 and Arabidopsis thaliana AtSWEET7) capable of co‐transporting glucose and xylose from previously unexplored oleaginous yeasts and plants. Kinetic analysis showed that LST1_205437 had lenient glucose inhibition on xylose transport and AtSWEET7 transported glucose and xylose simultaneously with no inhibition. Modelling studies of LST1_205437 revealed that Ala335 residue at sugar binding site can accommodates both glucose and xylose. Docking studies with AtSWEET7 revealed that Trp59, Trp183, Asn145, and Asn179 residues stabilized the interactions with sugars, allowing both xylose and glucose to be co‐transported. In addition, we altered sugar preference of LST1_205437 by single amino acid mutation at Asn365. Our findings provide a new mechanistic insight on glucose and xylose transport mechanism of sugar transporters and the identified sugar transporters can be employed to develop engineered yeast strains for producing cellulosic biofuels and chemicals.
Identification of three immune molecular subtypes associated with immune profiles, immune checkpoints, and clinical outcome in multiple myeloma
Authors: Gao Guangtao , Fang Mengkun , Xu Peipei , Chen Bing 
Published: August 2021

AbstractPurposeTo identify the immune molecular subtype for MM to help achieve individualized and precise targeted therapy.MethodsThe GDC API was used to download the TCGA‐MM profile dataset, which contains 859 samples in total, all of which were anterior to the standard treatment after diagnosis. Moreover, 282, 298, and 258 samples were stage I, stage II, and stage III separately. We used the immune gene expression profile for consistent clustering; and used the R software package ConsensusClusterPlus to sort the immune molecular subtypes. Correlation between subtypes and clinical features, immunity, and prognosis was then analyzed.ResultsA total of 859 tumor samples were separated into these three subtypes, which were not meaningfully related to age or sex but showed a remarkable association with stage. The results suggested that obvious differences in immune metagene expression and expression of 10 immune checkpoint genes appeared among the three subtypes.ConclusionThe three subtypes are distinctly different in terms of immune metagenes, immune checkpoint molecules, and clinical prognosis. The discovery of the immune microenvironment of MM could further reveal the strategy for immunotherapy in MM and provide a promising candidate prognostic tool for survival.
Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing
Authors: Duan Li , Ouyang Kan , Wang Jianhong , Xu Limei , Xu Xiao , Wen Caining , Xie Yixin , Liang Yujie , Xia Jiang 
Published: August 2021

AbstractTherapeutic genome editing harnesses the power of genome editing tools to correct erroneous genes associated with disease pathology. To bring the CRISPR/Cas9 tool from the bench to the bedside, a critical hurdle is the safe and efficient delivery of this nucleic acid tool to the desired type of cells in patients. This review discusses the use of natural carriers, extracellular vesicles (EVs), in particular exosomes, to fill the gap. Exosomes are lipid‐containing nanovesicle released by various types of cells to mediate cell‐cell communications. Their inherent long‐distance transportation capability, biocompatibility, and engineerability have made EVs potential vehicles for delivering therapeutic drugs. We summarize the recent progress of harnessing exosomes as delivery vehicles for the CRISPR/Cas system to achieve therapeutic gene editing for disease treatment, with a focus on various strategies to achieve selective delivery to a particular type of cell and efficient packaging of the genome editing tools in the vesicles. Critical issues and possible solutions in the design and engineering of the targeting vehicles are highlighted. Taken together, we demonstrate EV/exosome‐mediated packaging of the nucleic acid/protein tools and the cell/tissue‐targeted delivery to be a viable way towards the clinical translation of the CRISPR/Cas9 technology.
The use of a vascularized pedicle jejunal graft as a treatment for anastomosis dehiscence after transanal pull‐through, with a combined approach, in two dogs
Authors: Falerno Ilaria , Collivignarelli Francesco , Vignoli Massimo , Paolini Andrea , Tamburro Roberto 
Published: August 2021

AbstractA pedicled jejunal graft was successfully used to treat a colorectal anastomotic dehiscence, which eliminated the tension on the anastomotic site.
Ultra‐high‐density mapping to guide effective His‐bundle pacing
Authors: Covino Gregorio , Magliano Paolo Liberato , Colimodio Filomena , Auricchio Claudia , Provvisiero Ciro , Volpicelli Mario 
Published: August 2021

AbstractPermanent His bundle pacing is a physiological alternative to right ventricular pacing, resulting in a lower probability of pacing‐induced cardiomyopathy and left ventricular ejection fraction deterioration. The combined use of UHD mapping systems allows precise and detailed information on the His bundle location, possibly providing more pacing option locations.
Report of a novel missense mutation in the MECP2 gene in a middle‐aged man with intellectual disability syndrome
Authors: Arvio Maria , Haanpää Maria , Pohjola Pia , Lähdetie Jaana 
Published: August 2021

AbstractExome sequencing revealed the cause of our 35‐year‐old male patient's progressive and severe intellectual and motor disability, namely a previously undescribed missense mutation of MECP2.
Traumatic neuroma of the bile duct: A case report
Authors: Nechi Salwa , Nakhli Abdelwahab , Ben Hamida Wiem , Bani Amina , Khsiba Amal , Ben Mohamed Asma , Chelbi Emna , Hamzaoui Lamine , Touinsi Hassan 
Published: August 2021

AbstractWe report the case of a bile duct traumatic neuroma in a 76‐year‐old man who presented with obstructive jaundice one year after cholecystectomy. Despite the radiological examinations, the preoperative diagnosis was difficult. The patient underwent a biliary resection with choledoco‐duodenal anastomosis
An unusual case of osteoarthritis?
Authors: Teixeira Mariana , Ricardo Pires Joana , Ferreira Filipa Coroado , Rabadão Tiago , Aveiro Marcelo , Neves Nuno , Neves Clarinda 
Published: August 2021

AbstractForestier disease is a condition characterized by calcification and ossification of ligaments and entheses particularly affecting axial skeleton. Diagnosis is difficult and mandates a high suspicion level, but unexpensive and accessible examinations like a simple radiography might provide useful diagnostic clues in these challenging clinical scenarios and improve clinical assistance.
Dramatic response to albendazole in transplantation candidates with unresectable hepatic alveolar hydatid disease
Authors: Ocak Sönmez , Poyanlı Arzu , Güllüoğu Mine , İbiş Cem , Tekant Yaman , Özden İlgin 
Published: August 2021

AbstractLong‐term albendazole treatment should be given to all patients with unresectable hepatic alveolar echinococcosis as dramatic regression is possible in 15%–20%. It may be prudent to prepare a living donor for possible salvage transplant in case of a severe complication. Preemptive transplantation in mildly symptomatic patients should be discouraged.
Nasal‐type T‐cell lymphoma referred as fungal rhinosinusitis: Case report
Authors: Almazrouei Aaesha , Sabri Alain Michel 
Published: August 2021

AbstractNKTCL is a rare and destructive midline tumor that can be easily misdiagnosed as other more common inflammatory processes. The differential diagnosis of NKTCL should always be kept in mind for any lesion of the paranasal sinuses with atypical presentation and nonresponsive to conventional treatments.
Disseminated Nocardia infection—A rare presentation
Authors: Arora Harkesh , Ramalingam Sathishkumar , Sanghavi Rajvee , Balogun Adedayo , Muruganandam Maheshwari 
Published: August 2021

AbstractNocardia infection is rare and requires early diagnosis, extended use of sulfonamides for good prognosis, and prevention of recurrence. It is crucial to suspect nocardiosis in cases of atypical pneumonias or unexplained visceral organ dysfunction.
Impella insertion for residual aortic dissection
Authors: Yoshida Hisashi , Ichihara Yuki , Hoki Ryogo , Niinami Hiroshi 
Published: August 2021

AbstractAcute aortic dissection with coronary malperfusion is a life‐threatening disease, resulting in demanding postoperative management. We report a successful insertion of percutaneous heart pump Impella through the intact true lumen in a patient with residual aortic dissection after the graft replacement. Careful evaluation of the access site and the Impella size selection is required.
Spontaneous coronary artery dissection in the third trimester—Implications for investigation and delivery
Authors: Paxton‐Hall Thomas , Desai Pranali , Seton Nicholas , Arthur Chris 
Published: August 2021

AbstractThis case of spontaneous coronary artery dissection in pregnancy highlights the diagnostic, treatment and delivery dilemmas in the antepartum period. This is a rare condition that usually manifests in the postpartum period. This case provides multidisciplinary considerations that were encountered for optimal maternal and fetal outcome.