bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tren Model Bisnis Kolaborasi Antar Perusahaan Startup Perspektif Bisnis Islam
Authors: Tazkiyyaturrohmah Rifqy 
Published: February 2021

Memasuki era industri 4.0 membuka peluang besar bagi bisnis digital di Indonesia. Para pelaku bisnis yang mayoritas berasal dari generasi milenial tentu turut meramaikan gaung ini. Perusahaan rintisan (startup) yang biasanya bergerak di bidang teknologi dan aplikasi secara perlahan namun pasti turut mengalami perkembangan yang signifikan. Dibuktikan dengan beberapa data yang menyebutkan bahwa Indonesia menempati peringkat ke empat dunia dalam jumlah perusahaan startup. Bahkan Indonesia sendiri setidaknya memiliki 4 unicorn dari jumlah total 8 unicorn di ASEAN. Terdapat beberapa faktor yang mempengaruhi perkembangan startup di Indonesia, salah satunya adalah model bisnis kolaorasi antar beberapa startup untuk mengembangkan perusahaan. Disini peneliti ingin memaparkan bagaimana bisnis kolaborasi itu jika dilihat melalui perspekttif Islam. Penelitian ini merupakan penelitian kualitatif dengan metode deskriptif, yang mana memfokuskan kepada studi fenomenologi. Hasil dari penelitian ini adalah bisnis kolaborasi antar perusahaan startup dianggap sudah memenuhi unsur-unsur etika bisnis dalam Islam, yang memuat kesatuan, kejujuran, keadilan, kebenaran, kebajikan, kehendak bebas dan tanggung jawab. Pola bisnis kolaborasi pun dirasa cukup menguntungkan bagi semua pihak, baik antar perusahaan startup yang melakukan kolaborasi dan juga bagi masyarakat yang menjadi konsumen. [Entering the fourth industrial era, it opens up a great opportunities for digital businesses in Indonesia. The majority of business people who come from millennial generation certainly helped enliven this phenomenon. Startups which are usually engaged in technology and applications are slowly but surely also experiencing the significant developments. Evidenced by some data that says that Indonesia ranks fourth in the world in the number of startup companies. Indonesia also has at least 4 unicorns out of a total of 8 unicorns in ASEAN. There are several factors that influence the development of startups in Indonesia, one of which is the business model of collaboration between several startups to develop a company. Through this study, the researcher explains the collaboration of business that viewed by the perspective of Islam. This research is a qualitative research with the descriptive method, which focuses on the study of phenomenology. The results of this study are the business collaboration between startup companies considered to have fulfilled the elements of business ethics in Islam, which contain unity, fair, equilimbrium, truth, wisdom, free will and responsibility. The business collaboration pattern is also considered quite beneficial for all parties, both startup companies that collaborate and also for people who are the consumers.]
Smartphone Based Alerting of First Responders During the COVID-19 Pandemic
Authors: Ganter Julian , Damjanovic Domagoj , Trummer Georg , Busch Hans-Jörg , Baldas Klemens , Hänsel Mike , Müller Michael Patrick 
Published: February 2021

Abstract
Background

Smartphone Alerting Systems (SAS) for first responders potentially shorten the resuscitation-free interval of patients with acute cardiac arrest. During the COVID-19 pandemic, many systems were suspended due to potential risks for the responders. Therefore, a COVID-19 concept for the SAS in Freiburg/Germany was established and evaluated.
Methods

Due to the pandemic, SAS was stopped in March 2020. A concept for a safe restart was elaborated with provision of a set with ventilation bag/mask, airway filter and personal protective equipment (PPE) for every volunteer. A standard operating procedure followed the COVID-19 guidelines of the European Resuscitation Council (ERC). Willingness of the participants to respond alarms during the pandemic was investigated using an online survey.
Results

The system was restarted in May 2020. The willingness to respond to alarms was lower during the pandemic without PPE. It remained lower than before the pandemic when the volunteers had been equipped with PPE, but the alarm response rate remained at approximately 50% during the ongoing pandemic.
Conclusions

When volunteers are equipped with PPE, the operation of a SAS does not need to be paused, and the willingness to respond remains high among first responders.
Comprehensive single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells
Authors: Mincarelli Laura , Uzun Vladimir , Wright David , Rushworth Stuart , Haerty Wilfried , Macaulay Iain 
Published: February 2021

Abstract
Single-cell approaches have revealed that the haematopoietic hierarchy is a continuum of differentiation, from stem cell to committed progenitor, marked by changes in gene expression. However, many of these approaches neglect isoform level information, and thus do not capture the extent and effect of alternative splicing within the system. Here, we present the first integrated short- and long-read single-cell RNA-seq of haematopoietic stem and progenitor cells. We demonstrate that over half of genes detected in standard short-read single-cell analyses are expressed as multiple, often functionally distinct, isoforms. This includes many transcription factors and key cytokine receptors, and in particular the Thrombopoietin receptor Mpl, which displays complex isoform expression patterns between individual hematopoietic stem cells. The dataset further reveals novel signatures of hematopoietic ageing, including a global increase in lncRNA expression. Strikingly, the long-read sequencing enables us to observe aberrant expression of full-length VJ-rearranged immunoglobulin kappa transcripts in aged haematopoietic stem cells, prior to lymphoid commitment. Integrating single cell and cell-type specific isoform landscape in normal and aged hematopoiesis provides a new reference for accurate molecular profiling of heterogeneous tissues, as well as novel insights into transcriptional complexity, cell-type specific splicing events and effects of ageing.
Safety and Efficacy of Hypofractionated Stereotactic Radiotherapy with Anlotinib Targeted Therapy for Glioblastoma at First Recurrence: A Preliminary Report
Authors: Guan Yun , Li Jing , Gong Xiu , Zhu Huaguang , Li Chao , Mei Guanghai , Liu Xiaoxia , Pan Li , Dai Jiazhong , Wang Yang , Wang Enmin , Wang Xin , Liu Ying 
Published: February 2021

Abstract
BackgroundThe optimal treatment for recurrent glioblastoma (rGBM) remains uncertain. Hypofractionated stereotactic radiotherapy (HSRT) and anti-vascular endothelial growth factor (VEGF) antibodies (e.g., bevacizumab) have been reported to have a promising survival benefit and acceptable toxicity in recent studies. Anlotinib is a new orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR) and c-kit. It has dual anti-angiogenic and anti-tumour growth effects. This preliminary study describes our initial experience with HSRT and anlotinib as a salvage treatment for rGBM.MethodsBetween December 2019 and June 2020, rGBM patients treated with HSRT using CyberKnife concurrently with anlotinib were retrospectively analysed. Anlotinib was prescribed at 12 mg daily during HSRT. Adjuvant anlotinib was administered at 12 mg d1-14 every 3 weeks. The primary endpoint was the objective response rate (ORR) determined by the treating investigators using the Response Assessment in Neuro-Oncology (RANO) criteria, and secondary endpoints included overall survival (OS), progression-free survival (PFS) after salvage treatment, and toxicity. Toxicity was assessed using the Common Terminology Criteria for Adverse Events (CTCAE) 5.0.ResultsWe retrospectively reviewed five patients who received salvage HSRT and anlotinib for recurrent GBM.The median planning target volume (PTV) was 26.94 cm3 (5.53–54.41 cm3). The prescribed dose was 25.0 Gy in 5 fractions. The median number of cycles of anlotinib was 9 (4–15) cycles. The median baseline Karnofsky Performance Status (KPS) was 80 (70–90). The follow-up ranged from 4 to 10 months. The ORR was 100%. Three (60%) patients had a best outcome of a partial response (PR), and 2 (40%) achieved a complete response (CR). No patients died or had progressive disease (PD) at the last follow-up. Two patients had grade 2 hand-foot syndrome, which was relieved after dermatologic treatments, and no other grade 3 or higher toxicities were recorded.ConclusionsSalvage HSRT combined with anlotinib showed a favourable outcome and acceptable toxicity for rGBM patients in this preliminary report. A prospective phase II study (NCT04197492) is ongoing to further investigate the value of HSRT combined with anlotinib in rGBM.
Low-dose nanotherapy-mediated site-specific inhibition of neutrophil extracellular traps for immunoregulatory treatment of asthma
Authors: Ma Yongchang , Li Lanlan , Hu Yi , Han Songling , Yang Qinghua , Pu Wendan , Zhang Xiangjun , Zhang Jianxiang 
Published: February 2021

Abstract
Asthma, one of the most common lung diseases, remains a serious global healthy problem. Currently there is still an urgent need for effective and safe therapies against severe asthma. Neutrophil extracellular traps (NETs) have emerged as a new therapeutic target for different diseases, while precision regulation of NETs is highly challenging. Here, we report site-specific attenuation of oxidative stress in lung neutrophils via a cyclic oligosaccharide-derived nanotherapy (termed as TPCN) effectively inhibited the development of mouse neutrophilic asthma, a typical phenotype of severe asthma. Therapeutically, TPCN delivered via either intravenous injection or inhalation can distribute in lung neutrophils of asthmatic mice, thereby significantly mitigating oxidative stress, suppressing inflammatory responses, reversing airway remodelling, and improving pulmonary function. Notably, TPCN is effective even at an actual inhalation dose as low as 0.063 mg/kg. Mechanistically, therapeutic benefits of TPCN are achieved by inhibiting reactive oxygen species (ROS)-induced formation of NETs, which further promotes immune homeostasis via regulating balance between regulatory T (Treg) and T helper 17 (Th17) cells. Thus, TPCN holds great promise for precision therapy of neutrophilic asthma, while the ROS-NETs-Treg/Th17 pathway can function as intriguing therapeutic targets for the treatment of severe asthma and other neutrophil-mediated inflammatory diseases.
Explosion as a phase transition due to the change of the gradient symmetry of the distortion tensor.
Authors: Braginsky Alexander 
Published: February 2021

Abstract
It is shown that the destruction of a continuous elastic medium is a phase transition associated with a change in the gradient symmetry of the equations of state for the distortion tensor. The equations of state for the distortion tensor, as a compensating field of the minimal fundamental interaction, are derived from the action minimum. In a continuous elastic medium, the distortion tensor is proportional to the conjugate stress tensor. The continuous medium is destroyed at critical stresses or pressures. At the same time, the vortex tension of the distortion tensor penetrates into it and the elasticity disappears. As a result of this phase transition, linear defects and cracks are formed in solids state, and high-temperature plasma occurs in the gas and an explosion occurs. It is shown that the explosion and lightning are the same phase transition, which is caused by the occurrence of a critical vortex tension of the distortion tensor.
The minimal interaction induced by the translation subgroup has a gap and possible relates to the strong fundamental interaction.
Authors: Braginsky Alexander 
Published: February 2021

Abstract
The paper investigates the low-symmetric state of the compensating field of the distortion tensor and proves that there is a gap in this state. It is shown that the distortion tensor is the compensating field of the minimal interaction induced by the translation subgroup. On the example of electron pairing in a Cooper pair it was proved that the distortion tensor is responsible for the electron-phonon interaction. In this paper, for the first time, an exact wave solution for sound pressure in a continuous medium is obtained from the equations of state for the distortion tensor. It is shown that the sound is described as "massive" wave of the distortion tensor, the spectrum of which has the minimal frequency, which corresponds to a gap. The presence of a gap in the low-symmetric state gives grounds to believe that the distortion tensor, as a compensating interaction field, describes a strong fundamental interaction. As it is known, the description of the gap in the strong fundamental interaction is declared a Millennium problem by the Clay Mathematical Institute (CMI).
Unveiling the third dimension in morphometry with automated quantitative volumetric computations
Authors: Frank Lawrence R. , Rowe Timothy B. , Boyer Doug M. , Witmer Lawrence M. , Galinsky Vitaly L. 
Published: February 2021

Abstract
As computed tomography and related technologies have become mainstream tools across a broad range of scientific applications, each new generation of instrumentation produces larger volumes of more-complex 3D data. Lagging behind are step-wise improvements in computational methods to rapidly analyze these new large, complex datasets. Here we describe novel computational methods to capture and quantify volumetric information, and to efficiently characterize and compare shape volumes. It is based on innovative theoretical and computational reformulation of volumetric computing. It consists of two theoretical constructs and their numerical implementation: the spherical wave decomposition (SWD), that provides fast, accurate automated characterization of shapes embedded within complex 3D datasets; and symplectomorphic registration with phase space regularization by entropy spectrum pathways (SYMREG), that is a non-linear volumetric registration method that allows homologous structures to be correctly warped to each other or a common template for comparison. Together, these constitute the Shape Analysis for Phenomics from Imaging Data (SAPID) method. We demonstrate its ability to automatically provide rapid quantitative segmentation and characterization of single unique datasets, and both inter-and intra-specific comparative analyses. We go beyond pairwise comparisons and analyze collections of samples from 3D data repositories, highlighting the magnified potential our method has when applied to data collections. We discuss the potential of SAPID in the broader context of generating normative morphologies required for meaningfully quantifying and comparing variations in complex 3D anatomical structures and systems.
Changes in Prevalence of Nosocomial Infection Pre- and Post-COVID-19 pandemic from a Tertiary Hospital in China
Authors: Su Chunmei , Zhang Zhiqin , Zhao Xu , Peng Hanlin , Hong Yi , Huang Lili , Huang Jie , Yan Xiangming , Wu Shuiyan , Bai Zhenjiang 
Published: February 2021

Abstract
Background: Nosocomial infections (NIs) are an important cause of mortality, and increasing evidence reveals that the prevalence of NIs can be reduced through effective prevention and control measures. The aim of this study was to investigate the impact of the prevention and control measures for the COVID-19 pandemic on NIs.Methods: A retrospective study was conducted to analyze the prevalence of NIs before and after COVID-19 pandemic for six months in the Children’s Hospital of Soochow University.Results: A total of 39,914 patients in 2019 and 34,645 patients in 2020 were admitted to the hospital during the study. There were 1.39% (481/34645) of patients with NIs in 2020, which was significantly lower than the 2.56% (1021/39914) of patients in 2019. The rate of critical and fatal cases was also decreased. Except for the ICU, the prevalence of nosocomial infection in most departments decreased from 2019 to 2020. Regarding the source of infections, a significant reduction was mainly observed in respiratory (0.99% vs 0.42%, p=0.000) and digestive tract (0.63% vs 0.14%, p=0.000). The microorganism analysis of respiratory infections indicated an obvious decline in acinetobacters and fungi. The most significant decline of pathogens in gastrointestinal infections was observed for rotavirus. The comparison of catheter-related nosocomial infections between 2019 and 2020 did not show significant differences. Conclusions: The prevention and control measures for the COVID-19 pandemic have reduced the nosocomial infection in almost all departments, except the ICU, mainly regarding respiratory, gastrointestinal, and oral infections, while catheter-related infections did not show any differences.
A Cross Sectional Analysis of Physical Activity Engagement in Adults with Mild Cognitive Impairment
Authors: Connolly Leona , Power Joanna McHugh , Lawlor Brian 
Published: February 2021

Abstract
Background

To address the paucity of literature regarding the relationship between mild cognitive impairment and physical activity engagement, this study aimed to understand the relative contribution of cognitive, demographic, physical and psychological variables related to physical activity engagement in individuals with mild cognitive impairment.
Method

This was a descriptive, cross – sectional study of secondary data from 62 participants with MCI (mean age 70.53, SD = 6.34), 53.2% female, median MoCA 23 (IQR: 20, 24)) from the NeuroExercise study, a 12 – month PA intervention on the outcome of cognitive function. The independent variable of interest was global cognitive function. Age, gender, years of education, number of medications, handgrip strength, depression, and quality of life were treated as covariates. The dependent variable was PA engagement in minutes per week, using the LAPAQ physical activity questionnaire and the Actigraph triaxial accelerometer device.
Results

Hierarchical regression analyses showed no significant effect of cognitive function on physical activity engagement after controlling for the effects of covariates. Physical activity engagement was low relative to global physical activity guidelines ((M = 111.38, SD = 94.29) Actigraph ( t (51) = -2.95, p < .005) and the LAPAQ (M = 51.71, SD = 22.80), t (61) = -33.94, p = < .001)). A Bland- Altman measure of agreement demonstrated that objective and subjective measures of physical activity were not equivalent.
Conclusions

This sample of adults with MCI were not sufficiently physically active. Further, there was substantial variability between objective and subjective measures of physical activity engagement. Objective measurement of PA data may be more reliable for adults with mild cognitive impairment.
Effects of the Liaison Nurse Management on the Infectious Stroke Complications: A Randomized Controlled Trial
Authors: Kalani Zohreh , Ebrahimi Sedigheh , Fallahzadeh Hossein 
Published: February 2021

Abstract
Background
Two of the most serious complications after stroke are pneumonia, and urinary tract infection. Liaison nurse, from hospital admission to discharge and then at home helps patients with complicated caring issues stroke. This study investigates the effect of liaison nurse management on the incidence of pneumonia and urinary tract infection in patients with stroke after discharge from the hospital.
Methods
This randomized controlled trial was conducted on 80 patients in a hospital in Iran. The intervention group was assessed and developed a caring program by the liaison nurse and the control group received routine care. Two weeks and two months after discharge, the patients were evaluated for the incidence of pneumonia and urinary tract infection. Collected data were analyzed using the Chi-square test. P < 0.05 was considered statistically significant.
Results
The two groups were homogenous in terms of mean age; gender frequently distribution, and having urinary catheter. The incidence of pneumonia in intervention and control groups (11.6% vs. 19.2%, P = 0.35) had no statistically significant differences, but there was a significant difference in the incidence of urinary tract infection (0% vs. 24.6%, P < 0.001).
Conclusions
With liaison nurse performance, there was a significant difference in the incidence of urinary tract infection, in two months after discharge from hospital, but the incidence of pneumonia had no statistically significant differences in two groups. Nurse's evaluation each patient individually according to needs, developing and monitoring the home-based care program, beyond overall education to these patients, could reduce some of complications of a stroke.
Trial registration:
This study is retrospectively registered by Iranian Registry of Clinical Trials with decree code: IRCT20170605034330N3 on April 4, 2018.
Modeling Grape Leaf Quality Using Image Processing Technique
Authors: Hashemi Mohammad Mohammadi , Bahmani Omid 
Published: February 2021

Abstract
Grapes are familiar fruits in the Mediterranean, Central Europe and Southwest Asia. Various components of this plant have many uses, including leaves used in the preparation of foods. The quality of the grape leaves is especially important for the preparation of food and this requires careful consideration. One of the indicators of grape leaf selection in food is its surface integrity and absence of grooves. In this paper, by using image processing technique, the geometrical characteristics of the grape leaf including its area and perimeter are extracted and numerical value is given based on the defined index. For this purpose, leaves of four grape varieties were collected from different areas of Boroujerd City in Iran and modeling was done according to this research method. By categorizing the results that range between zero and one, two grape varieties have better Quality Index than other varieties and it is suggested as a suitable type for leaf use.