bluuebunny/crossref_metadata_2025_split huggingface dataset:
General Affine Invariances Related to Mahler Volume
Authors: Xi Dongmeng , Zhao Yiming 
Published: April 2021

AbstractGeneral affine invariances related to Mahler volume are introduced. We establish their affine isoperimetric inequalities by using a symmetrization scheme that involves a total of $2n$ elaborately chosen Steiner symmetrizations at a time. The necessity of this scheme, as opposed to the usual Steiner symmetrization, is demonstrated with an example (see the Appendix).
Hiding in Plain Sight: Pedagogy and Power
Authors: Timperley Claire , Schick Kate 
Published: April 2021

Abstract
Pedagogy is fundamental to scholarship of global politics but too often remains unseen. Moreover, when it is seen, it is largely regarded as a narrow epistemological engagement concerned with the transmission of knowledge. We argue that pedagogies should be recognized as an ontological undertaking, shaping how we know, relate, and act. We draw attention to the subversive and generative potential of critical and creative pedagogies to critically interrogate dominant power structures and hegemonic narratives. The purpose of this article is not so much to point International Relations educators toward particular pedagogical practices, but to provoke reflection on what the pedagogies we habitually employ bring into being and what they foreclose. Revealing pedagogies as a source of power encourages intentional pedagogical practices to critique, diversify, and re-story global politics. In the final section of the article, we outline some of the ways we have transformed our pedagogical practices in recent years, paying particular attention to relationality and awareness of place and context.
Subversive Knowledge in Times of Global Political Crisis: A Manifesto for Ethnography in the Study of International Relations
Authors: Brigden Noelle , Mainwaring Ċetta 
Published: April 2021

Abstract
This paper explores the promises and pitfalls of using ethnographic methods to analyze global politics in turbulent times. Ethnography has not gone unnoticed by international relations (IR) scholars, but the method remains at the fringes of the discipline. While acknowledging more recent feminist and practice theorist contributions to ethnographic research in IR, this paper brings together contemporary research across diverse issue areas, ranging from humanitarian intervention to transnational migration, to ask about ethnography's larger contribution to understanding global politics: What kinds of knowledge does ethnography produce about IR? In what ways might ethnography, informed by local perspectives, challenge top-down approaches to the study of IR? We identify three primary justifications for ethnographic methods based on different, though overlapping, forms of knowledge that they can uncover: tacit knowledge, marginalized knowledge, and subversive knowledge. We acknowledge issues that complicate access, and we warn that ethnographers are far from immune to the imperialist arrogance of mainstream methodologies. Ultimately, we call for reflexive scholarship to navigate the international politics of a “post-truth” and post-Covid world.
Paradigms and Practice
Authors: Jabko Nicolas , Schmidt Sebastian 
Published: April 2021

AbstractThomas Kuhn's concept of paradigm has long been a part of ordinary parlance in political science. Aside from its role in metatheoretical debate, scholars have enlisted the paradigm concept to explain policy change, particularly in the international political economy (IPE) literature. In this context, policy paradigms are defined primarily in ideational terms and with respect to a specific domain of policymaking. We argue that this stance overstates the ideational coherence of policymaking and runs a risk of reification. We re-evaluate the paradigm concept by drawing a link to the recent literature on norm change that emphasizes the importance of practice and process. This analysis highlights theoretical difficulties in using the paradigm concept, as the relation of ideas to practical logics elides the distinctness of paradigmatic frameworks. Without clear boundaries, paradigms lose much of their analytical purchase. While the paradigm concept initially proved useful in highlighting the role of ideas, it is time to recognize its limits in explaining stability and change in policymaking.
Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid
Authors: Dorn Christoph , Petroff David , Stoelzel Melanie , Kees Martin G , Kratzer Alexander , Dietrich Arne , Kloft Charlotte , Zeitlinger Markus , Kees Frieder , Wrigge Hermann , Simon Philipp 
Published: April 2021

Abstract

Objectives
To assess plasma and tissue pharmacokinetics of cefazolin and metronidazole in obese patients undergoing bariatric surgery and non-obese patients undergoing intra-abdominal surgery.

Patients and methods
Fifteen obese and 15 non-obese patients received an IV short infusion of 2 g cefazolin and 0.5 g metronidazole for perioperative prophylaxis. Plasma and microdialysate from subcutaneous tissue were sampled until 8 h after dosing. Drug concentrations were determined by HPLC-UV. Pharmacokinetic parameters were calculated non-compartmentally.

Results
In obese patients (BMI 39.5–69.3 kg/m2) compared with non-obese patients (BMI 18.7–29.8 kg/m2), mean Cmax of total cefazolin in plasma was lower (115 versus 174 mg/L) and Vss was higher (19.4 versus 14.2 L). The mean differences in t½ (2.7 versus 2.4 h), CL (5.14 versus 4.63 L/h) and AUC∞ (402 versus 450 mg·h/L) were not significant. The influence of obesity on the pharmacokinetics of metronidazole was similar (Cmax 8.99 versus 14.7 mg/L, Vss 73.9 versus 51.8 L, t½ 11.9 versus 9.1 h, CL 4.62 versus 4.13 L/h, AUC∞ 116 versus 127 mg·h/L). Regarding interstitial fluid (ISF), mean concentrations of cefazolin remained &gt;4 mg/L until 6 h in both groups, and those of metronidazole up to 8 h in the non-obese group. In obese patients, the mean ISF concentrations of metronidazole were between 3 and 3.5 mg/L throughout the measuring interval.

Conclusions
During the time of surgery, cefazolin concentrations in plasma and ISF of subcutaneous tissue were lower in obese patients, but not clinically relevant. Regarding metronidazole, the respective differences were higher, and may influence dosing of metronidazole for perioperative prophylaxis in obese patients.
Computability and the Symmetric Difference Operator
Authors: Andrews Uri , Gerdes Peter M , Lempp Steffen , Miller Joseph S , Schweber Noah D 
Published: April 2021

Abstract
Combinatorial operations on sets are almost never well defined on Turing degrees, a fact so obvious that counterexamples are worth exhibiting. The case we focus on is the symmetric-difference operator; there are pairs of (nonzero) degrees for which the symmetric-difference operation is well defined. Some examples can be extracted from the literature, e.g. from the existence of nonzero degrees with strong minimal covers. We focus on the case of incomparable r.e. degrees for which the symmetric-difference operation is well defined.
The Association of Mitochondrial Copy Number With Sarcopenia in Adult Survivors of Childhood Cancer
Authors: McCastlain Kelly , Howell Carrie R , Welsh Catherine E , Wang Zhaoming , Wilson Carmen L , Mulder Heather L , Easton John , Mertens Ann C , Zhang Jinghui , Yasui Yutaka , Hudson Melissa M , Robison Leslie L , Kundu Mondira , Ness Kirsten K 
Published: April 2021

Abstract

Background
Adult childhood cancer survivors are at risk for frailty, including low muscle mass and weakness (sarcopenia). Using peripheral blood mitochondrial DNA copy number (mtDNAcn) as a proxy for functional mitochondria, this study describes cross-sectional associations between mtDNAcn and sarcopenia among survivors.

Methods
Among 1762 adult childhood cancer survivors (51.6% male; median age = 29.4 years, interquartile range [IQR] = 23.3-36.8), with a median of 20.6 years from diagnosis (IQR = 15.2-28.2), mtDNAcn estimates were derived from whole-genome sequencing. A subset was validated by quantitative polymerase chain reaction and evaluated cross-sectionally using multivariable logistic regression for their association with sarcopenia, defined by race-, age-, and sex-specific low lean muscle mass or weak grip strength. All statistical tests were 2-sided.

Results
The prevalence of sarcopenia was 27.0%, higher among female than male survivors (31.5% vs 22.9%; P &lt; .001) and associated with age at diagnosis; 51.7% of survivors with sarcopenia were diagnosed ages 4-13 years (P = .01). Sarcopenia was most prevalent (39.0%) among central nervous system tumor survivors. Cranial radiation (odds ratio [OR] = 1.84, 95% confidence interval [CI] = 1.32 to 2.59) and alkylating agents (OR = 1.34, 95% CI = 1.04 to 1.72) increased, whereas glucocorticoids decreased odds (OR = 0.72, 95% CI = 0.56 to 0.93) of sarcopenia. mtDNAcn decreased with age (β = −0.81, P = .002) and was higher among female survivors (β = 9.23, P = .01) and among survivors with a C allele at mt.204 (β = −17.9, P = .02). In adjusted models, every standard deviation decrease in mtDNAcn increased the odds of sarcopenia 20% (OR = 1.20, 95% CI = 1.07 to 1.34).

Conclusions
A growing body of evidence supports peripheral blood mtDNAcn as a biomarker for adverse health outcomes; however, this study is the first to report an association between mtDNAcn and sarcopenia among childhood cancer survivors.
Preoperative prediction of the localization of a solitary fibrous tumor using four-dimensional computed tomography: a case report
Authors: Nakamura Daisuke , Kobayashi Nobutaka , Miyazawa Masahisa , Satomi Hidetoshi 
Published: April 2021

Abstract
Solitary fibrous tumors of the pleura (SFTP) are relatively rare primary pleural tumors. Four-dimensional computed tomography (4D-CT) is reportedly useful in assessing parietal pleural invasion and adhesion in patients with lung cancer. We report a case in which 4D-CT was performed to evaluate SFTP localization and parietal pleural invasion and adhesions. A 62-year-old female presented with an abnormality on a chest radiograph. Chest CT revealed a well-demarcated solid nodule in the left lower lobe adjacent to the pleura. We considered that the tumor was intrapulmonary or arose from the visceral pleura, without adhesion or invasion to the chest wall based on 4D-CT. Primary lung cancer was suspected, and the tumor was resected. Pathological diagnosis revealed an SFTP. This case suggests that 4D-CT is useful in predicting the localization of SFTP and other thoracic tumors, assessing chest wall adhesion and invasion, and making surgical strategies.
The acidic domain of the chloroplast RNA-binding protein CP31A supports cold tolerance in Arabidopsis thaliana
Authors: Okuzaki Ayako , Rühle Thilo , Leister Dario , Schmitz-Linneweber Christian 
Published: April 2021

Abstract
The processing of chloroplast RNA requires a large number of nuclear-encoded RNA-binding proteins (RBPs) that are imported post-translationally into the organelle. The chloroplast ribonucleoprotein 31A (CP31A) supports RNA editing at 13 sites and also supports the accumulation of multiple chloroplast mRNAs. In cp31a mutants it is the ndhF mRNA (coding for a subunit of the NDH complex) that is most strongly affected. CP31A becomes particularly important at low temperatures, where it is essential for chloroplast development in young tissue. Next to two RNA-recognition motifs (RRMs), CP31A has an N-terminal acidic domain that is phosphorylated at several sites. We investigated the function of the acidic domain in the role of CP31A in RNA metabolism and cold resistance. Using point mutagenesis, we demonstrate that the known phosphorylation sites within the acidic domain are irrelevant for any of the known functions of CP31A, both at normal and at low temperatures. Even when the entire acidic domain is removed, no effects on RNA editing were observed. By contrast, loss of the acidic domain reduced the ability of CP31A to stabilize the ndhF mRNA, which was associated with reduced NDH complex activity. Most importantly, acidic domain-less CP31A lines displayed bleached young tissue in the cold. Together, these data show that the different functions of CP31A can be assigned to different regions of the protein: the RRMs are sufficient to maintain RNA editing and to allow the accumulation of basal amounts of ndhF mRNA, while chloroplast development under cold conditions critically depends on the acidic domain.
On a possibility of transfer of asteroids from the 2:1 mean motion resonance with Jupiter to the Centaur zone
Authors: Kazantsev Anatolii , Kazantseva Lilia 
Published: April 2021

ABSTRACT
The paper analyses possible transfers of bodies from the main asteroid belt to the Centaur region. The orbits of asteroids in the 2:1 mean motion resonance (MMR) with Jupiter are analysed. We selected the asteroids that are in resonant orbits with e &gt; 0.3 whose absolute magnitudes H do not exceed 16m. The total number of the orbits amounts to 152. Numerical calculations were performed to evaluate the evolution of the orbits over 100 000-yr time interval with projects for the future. Six bodies are found to have moved from the 2:1 commensurability zone to the Centaur population. The transfer time of these bodies to the Centaur zone ranges from 4600 to 70 000 yr. Such transfers occur after orbits leave the resonance and the bodies approach Jupiter. Where after reaching sufficient orbital eccentricities bodies approach a terrestrial planet, their orbits go out of the MMR. Accuracy estimations are carried out to confirm the possible asteroid transfers to the Centaur region.
Inferring Adaptive Codon Preference to Understand Sources of Selection Shaping Codon Usage Bias
Authors: de Oliveira Janaina Lima , Morales Atahualpa Castillo , Hurst Laurence D , Urrutia Araxi O , Thompson Christopher R L , Wolf Jason B 
Published: April 2021

Abstract
Alternative synonymous codons are often used at unequal frequencies. Classically, studies of such codon usage bias (CUB) attempted to separate the impact of neutral from selective forces by assuming that deviations from a predicted neutral equilibrium capture selection. However, GC-biased gene conversion (gBGC) can also cause deviation from a neutral null. Alternatively, selection has been inferred from CUB in highly expressed genes, but the accuracy of this approach has not been extensively tested, and gBGC can interfere with such extrapolations (e.g., if expression and gene conversion rates covary). It is therefore critical to examine deviations from a mutational null in a species with no gBGC. To achieve this goal, we implement such an analysis in the highly AT rich genome of Dictyostelium discoideum, where we find no evidence of gBGC. We infer neutral CUB under mutational equilibrium to quantify “adaptive codon preference,” a nontautologous genome wide quantitative measure of the relative selection strength driving CUB. We observe signatures of purifying selection consistent with selection favoring adaptive codon preference. Preferred codons are not GC rich, underscoring the independence from gBGC. Expression-associated “preference” largely matches adaptive codon preference but does not wholly capture the influence of selection shaping patterns across all genes, suggesting selective constraints associated specifically with high expression. We observe patterns consistent with effects on mRNA translation and stability shaping adaptive codon preference. Thus, our approach to quantifying adaptive codon preference provides a framework for inferring the sources of selection that shape CUB across different contexts within the genome.
PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases
Authors: Garg Ankur , Roske Yvette , Yamada Shinnosuke , Uehata Takuya , Takeuchi Osamu , Heinemann Udo 
Published: April 2021

Abstract
The CCCH-type zinc finger (ZnF) containing ZC3H12 ribonucleases are crucial in post-transcriptional immune homoeostasis with ZC3H12A being the only structurally studied member of the family. In this study, we present a structural-biochemical characterization of ZC3H12C, which is linked with chronic immune disorders like psoriasis. We established that the RNA substrate is cooperatively recognized by the PIN and ZnF domains of ZC3H12C and analyzed the crystal structure of ZC3H12C bound to a single-stranded RNA substrate. The RNA engages in hydrogen-bonded contacts and stacking interactions with the PIN and ZnF domains simultaneously. The ZC3H12 ZnF shows unprecedented structural features not previously observed in any member of the CCCH-ZnF family and utilizes stacking interactions via a unique combination of spatially conserved aromatic residues to align the target transcript in a bent conformation onto the ZnF scaffold. Further comparative structural analysis of ZC3H12 CCCH-ZnF suggests that a trinucleotide sequence is recognized by ZC3H12 ZnF in target RNA. Our work not only describes the initial structure-biochemical study on ZC3H12C, but also provides the first molecular insight into RNA recognition by a ZC3H12 family member. Finally, our work points to an evolutionary code for RNA recognition adopted by CCCH-type ZnF proteins.
Petrosal Approach With Preservation of the Superior Petrosal Sinus (the Graceful Petrosal) for Resection of Giant Trigeminal Schwannoma: 2-Dimensional Operative Video
Authors: Almefty Kaith K , Al-Mefty Ossama 
Published: April 2021

Abstract
Trigeminal schwannomas are benign tumors amendable to curative surgical resection.
1
Excellent outcomes, with preservation and improvement of cranial nerve function, including trigeminal nerve function, have been reported with microsurgical resection through skull base approaches.
2
Dumbell shaped tumors, involving the middle and posterior fossa, are more challenging.
3
They are resected via a middle cranial fossa approach with the expanded Meckel cave providing access to the posterior fossa. However, tumors with a large caudal extension below the internal auditory meatus typically cannot be adequately accessed with this approach and the posterior petrosal approach is utilized.
2
Specific venous anatomy might deter from cutting the tentorium. This article describes the surgical resection of a trigeminal schwannoma with a large posterior fossa component through a petrosal approach without cutting the tentorium.
4

The patient is a 34-yr-old man who presented with headaches and gait disturbance. Neurological exam revealed hypoesthesia and hypoalgesia in the left V1 and V2 distributions. Magnetic resonance imaging (MRI) revealed a large dumbbell-shaped schwannoma causing brainstem compression. Magnetic resonance venography (MRV) demonstrated temporal lobe venous drainage into the superior petrosal sinus and tentorium proximal to the transverse sigmoid junction.
A single temporal-suboccipital bone flap and a retro-labrynthine mastoidectomy were performed. The petrous apex was drilled and Meckle's cave opened. The presigmoid dura was opened and extended toward the petrous apex region beneath the tentorium. This provided access to and safe resection of the tumor. A gross total tumor resection was achieved. The patient remained stable neurologically and was without tumor recurrence at 3 yr postoperatively.
The patient had consented to the procedure.
Figures in video at 4:06 from Jafez et al, Preservation of the superior petrosal sinus during the petrosal approach, J Neurosurg. 2011;114(5):1294-1298, with permission from JNSPG.
Murray River Societies in Australia through the Lens of Bioarchaeology
Authors: Littleton Judith , Karstens Sarah , Allen Harry 
Published: April 2021

Abstract
The Murray River Valley was one of the most densely occupied areas of inland Australia during the Holocene. Unlike other areas of Australia, the record of burials and human remains dominates archaeological narratives of this area’s Aboriginal experience. In this article, we review bioarchaeological evidence from the region. In addition to mortuary remains, also discussed in this article are evidence from human morphological variation, palaeopathology, and diet. While the valley is often treated as a single region, Aboriginal communities who lived along the Murray shared aspects of economic and cultural systems but also demonstrated diversity and local trajectories. Rather than a single grand narrative the valley’s bioarchaeological evidence shows variation which is the product of multiple local factors.
HistoriciZing the ‘Dreaming’
Authors: Smith Mike 
Published: April 2021

Abstract
The ‘Dreaming’ is an elaborate belief system that forms the governing ideology of Indigenous Australia. It religiously sanctions the relationship between people and place, and articulates it in a large repertoire of land-based mythology. The historical development of the ‘Dreaming’ is not known in any detail. Salomon Reinach and Émile Durkheim at the turn of the twentieth century saw it as preserving an elementary form of religious life. However, the long history of Aboriginal societies in Australia (now known to be at least 50,000–60,000 years) suggests that this belief system may itself have a long history of development and elaboration. Taking arid Australia as a case study, this article outlines the principal features of the ‘Dreaming’ in its ethnographic form and asks how we might trace it archaeologically. On the basis of current evidence, the ‘Dreaming’, in its classic form, appears to have taken shape during the last few millennia when many of its perquisites emerge in the archaeological record, although the possibility that it has more ancient roots is not discounted.
Jazz Etiquette
Authors: Duranti Alessandro , Throop Jason , McCoy Matthew 
Published: April 2021

Abstract
The interaction among a group of musicians before, during, and after the performance of a jazz standard is analyzed to show the interdependence of jazz aesthetics and jazz ethics. The authors argue that what makes jazz distinct from other kinds of musical traditions is not just the ubiquity of improvisation in the genre but the vulnerability that jazz improvisation always generates—a vulnerability that is due to the genre’s reliance on both shared conventions and partly unpredictable individual choices. Analyzing video recordings of a university course on jazz organized to reproduce the setting of a jam session, the authors examine in detail the interactional assumptions and consequences of choices made by band members during the performance of “Softly, as in a Morning Sunrise.” The authors’ analysis shows how musicians position themselves to be responsive to one another as the song progresses, starting from an improvised “introduction” that sets the tempo, rhythm, and style of the song and continuing with smooth transitions from one solo to the next. Drawing from Erving Goffman’s ideas about the presentation of self and the phenomenology of Emmanuel Levinas, the authors examine the ethical implications of a musical “vacuum” that was created by one musician’s decision to wait to take his solo. In the interaction, the other musicians responded to the vacuum by assuming responsibility for the group’s performance and, more broadly, the performance of the jazz tradition, and this chapter uses their actions to illustrate how “jazz etiquette” operates as a practice that includes aesthetic, ethical, and practical concerns.