bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attack behaviour in naive gyrfalcons is modelled by the same guidance law as in peregrine falcons, but at a lower guidance gain
Authors: Brighton Caroline H. , Chapman Katherine E. , Fox Nicholas C. , Taylor Graham K. 
Published: February 2021

ABSTRACT
The aerial hunting behaviours of birds are strongly influenced by flight morphology and ecology, but little is known of how this relates to the behavioural algorithms guiding flight. Here, we used GPS loggers to record the attack trajectories of captive-bred gyrfalcons (Falco rusticolus) during their maiden flights against robotic aerial targets, which we compared with existing flight data from peregrine falcons (Falco peregrinus). The attack trajectories of both species were well modelled by a proportional navigation (PN) guidance law, which commands turning in proportion to the angular rate of the line-of-sight to target, at a guidance gain N. However, naive gyrfalcons operate at significantly lower values of N than peregrine falcons, producing slower turning and a longer path to intercept. Gyrfalcons are less manoeuvrable than peregrine falcons, but physical constraint is insufficient to explain the lower values of N we found, which may reflect either the inexperience of the individual birds or ecological adaptation at the species level. For example, low values of N promote the tail-chasing behaviour that is typical of wild gyrfalcons and which apparently serves to tire their prey in a prolonged high-speed pursuit. Likewise, during close pursuit of typical fast evasive prey, PN will be less prone to being thrown off by erratic target manoeuvres at low guidance gain. The fact that low-gain PN successfully models the maiden attack flights of gyrfalcons suggests that this behavioural algorithm is embedded in a guidance pathway ancestral to the clade containing gyrfalcons and peregrine falcons, though perhaps with much deeper evolutionary origins.
The North Samoyedic interrogative verb meaning ‘say what’
Authors: Mus Nikolett 
Published: February 2021

A cross-linguistically rare interrogative category (i.e., an interrogative verb with the meaning ‘say what’) is observed in the North Samoyedic (Uralic) languages. The interrogative verb in these languages is used in content questions, and functions as the predicate of the main or the embedded clause. It takes the regular verb morphemes with two exceptions: it (i) does not display object agreement, and (ii) cannot combine with the regular past tense morpheme. Furthermore, there is also an ordering restriction on multiple questions containing the interrogative verb. The morphosyntactic evidence suggests that the North Samoyedic interrogative verb is analyzed as a result of a wh-object incorporation.
Kokkuvõte. Nikolett Mus: Põhjasamojeedi keelte küsiverb tähendusega ‘mida ütlema’. Põhjasamojeedi (uurali) keeltes esineb keeleüleselt haruldane küsiv kategooria (st küsiverb tähendusega ’mis asja’). Nendes keeltes kasutatakse küsiverbi sisuküsimustes ja küsiverb toimib pea- või kõrvallauses predikaadina, liitudes tavaliste verbimorfeemidega, välja arvatud kahel juhul: küsiverb (i) ei väljenda objektiühildumist, ja (ii) ei kombineeru lihtmineviku morfeemiga. Lisaks on küsiverbil teatavad järjestuspiirangud küsiverbi sisaldava kompleksküsimuse korral. Morfosüntaktilised andmed viitavad, et põhjasamojeedi küsiverb on analüüsitav kui küsisõnalise objekti inkorporatsiooni tulemus.
Аннотация. Николетт Муш: Северосамодийский вопросительный глагол ‘что сказать’. В северосамодийских языках (уральская языковая семья) есть типологически редкий вопросительный глагол со значением ‘что сказать’. Этот глагол используется в частных вопросах в качестве предиката главного или подчиненного предложения. Он принимает обычные словоизменительные суффиксы за двумя исключениями: он не сочетается (i) с объектным спряжением и (ii) с показателем прошедшего времени индикатива. Кроме того, существуют ограничения на относительный порядок вопросов с вопросительным глаголом. Данные морфосинтаксиса свидетельствуют о том, что северносамодийский вопросительный глагол возник в результате инкорпорации объекта — вопросительного местоимениия.
A Supply Chain Theory of Factoring and Reverse Factoring
Authors: Kouvelis Panos , Xu Fasheng 
Published: February 2021

Factoring is a financial arrangement where the supplier sells accounts receivable to the factor against a premium and receives cash for immediate working capital needs. Reverse factoring takes advantage of the retailer’s payment guarantee and the credit rating differential between a small supplier and a large retailer, enabling the supplier to receive financing at a more favorable rate. We develop a supply chain theory of (recourse/non-recourse) factoring and reverse factoring showing when these post-shipment financing schemes should be adopted and who really benefits from the adoption. We find that recourse factoring is preferred when the supplier’s credit rating is relatively high, whereas non-recourse factoring is preferred within certain medium range of ratings. Both factoring schemes, if adopted, benefit both the supplier and the retailer, and thus the overall supply chain. Further, we find that reverse factoring may not always be preferred by suppliers compared to recourse and non-recourse factorings. Retailers should only offer reverse factoring to suppliers with low (but above a threshold) to medium credit ratings. The optimally designed reverse factoring program can always increase the retailer’s profit, but it may leave the supplier indifferent to the current factoring option when followed by an aggressive payment extension. More importantly, contrary to conventional wisdom, our theory implies that reverse factoring could be adopted even when the retailer has no credit rating advantage over the supplier, and it could benefit the retailer even without extending payment terms. This paper was accepted by Victor Martínez-de-Albéniz, operations management.
Leachate and Irrigation Sensor Development and Performance in Container Nursery Production
Authors: Cypher Quinn , Fulcher Amy , Wright Wesley C. , Sun Xiaocun , Fessler Lauren 
Published: February 2021

HighlightsUsing leaching fraction to schedule irrigation is recommended yet no automated measurement system exists.Sensors were developed to automatically measure leachate and irrigation within a sensor network.There was no difference between sensor measured and manually captured volume for sensors deployed in a nursery.After deployment in commercial nurseries, sensors accurately measured leachate and irrigation within 10% margin.Abstract. Nursery crops are often over-irrigated, resulting in wasted water and agrochemical inputs. Irrigating based on leaching fraction is recommended, yet an automated system for measuring and recording nursery container effluent (leachate) does not exist. The objective of this research was to develop and test a sensor-based system for real-time leachate and irrigation measurement in outdoor commercial nurseries. Sensors were developed to automatically measure irrigation and leachate volume in container nurseries that use overhead irrigation with the goal of facilitating the development of an automated leaching fraction-based irrigation system. Sensors were built using readily available components, including tipping bucket mechanisms calibrated to either 4.7 or 8.2 mL per tip, and were designed and constructed to function with commonly used 3.8-, 11.4-, and 14.5-L nursery containers. Sensor networks were developed in order to collect data from the sensors. Sensors were deployed at three commercial nurseries and tested using closed- and open-loop tests. Initially, a closed-loop test was performed on a subset of the sensors to test the integrity of the sensor-container system when subjected to an overhead irrigation delivery system. Following closed-loop tests, sensors were subjected to tests utilizing directed applications of water to compare sensor measurements with the volume of water applied and to compare sensor measurements over time (pre- and post-season). There was no difference between leachate measured by sensors and leachate captured and measured manually in closed-loop tests (p = 0.0570). In directed applications, sensors measured water flow with less than 3% margin at the beginning of the season (p = 0.0485) and less than 10% margin at the end of the season (p = 0.0390) regardless of container size. Pre- and post-season comparisons showed equivalence at the 10% margin for the 4.7-mL tipping bucket size (p = 0.0043) and at 5% for those calibrated to 8.2 mL per tip (p = 0.0198). Sensors deployed in commercial nurseries accurately measured leachate and irrigation within a 10% margin in real-time, on an individual plant scale, making them a viable option for a leaching fraction-based irrigation schedule. Keywords: Container effluent, Container-grown plants, Leaching fraction, Irrigation schedule, Sensor network.
Costs and outcomes of active and passive case detection for visceral leishmaniasis (Kala-Azar) to inform elimination strategies in Bihar, India
Authors: Dial Natalie J. , Medley Graham F. , Croft Simon L. , Mahapatra Tanmay , Priyamvada Khushbu , Sinha Bikas , Palmer Lucy , Terris-Prestholt Fern 
Published: February 2021

Background
Effective case identification strategies are fundamental to capturing the remaining visceral leishmaniasis (VL) cases in India. To inform government strategies to reach and sustain elimination benchmarks, this study presents costs of active- and passive- case detection (ACD and PCD) strategies used in India’s most VL-endemic state, Bihar, with a focus on programme outcomes stratified by district-level incidence.

Methods
Expenditure analysis was complemented by onsite micro-costing to compare the cost of PCD in hospitals alongside index case-based ACD and a combination of blanket (house-to-house) and camp ACD from January to December 2018. From the provider’s perspective, a cost analysis evaluated the overall programme cost of each activity, the cost per case detected, and the cost of scaling up ACD.

Results
During 2018, index case-based ACD, blanket and camp ACD, and PCD reported 1,497, 131, and 1,983 VL-positive cases at a unit cost of $522.81, $4,186.81, and $246.79, respectively. In high endemic districts, more VL cases were identified through PCD while in meso- and low-endemic districts more cases were identified through ACD. The cost of scaling up ACD to identify 3,000 additional cases ranged from $1.6–4 million, depending on the extent to which blanket and camp ACD was relied upon.

Conclusion
Cost per VL test conducted (rather than VL-positive case identified) may be a better metric estimating unit costs to scale up ACD in Bihar. As more VL cases were identified in meso-and low-endemic districts through ACD than PCD, health authorities in India should consider bolstering ACD in these areas. Blanket and camp ACD identified fewer cases at a higher unit cost than index case-based ACD. However, the value of detecting additional VL cases early outweighs long-term costs for reaching and sustaining VL elimination benchmarks in India.
Promoting sensitive parenting in ‘at-risk’ mothers and fathers: A UK outcome study of Mellow Babies, a group-based early intervention program for parents and their babies
Authors: Raouna Aigli , Malcolm Ruaridh , Ibrahim Raquib , MacBeth Angus 
Published: February 2021

Background
The objective of this study was to evaluate the effectiveness of Mellow Babies (MB) in the UK. MB is a 14-week early parenting intervention program that is delivered in groups and is targeted at ‘at-risk’ parents (both mothers and fathers) and their babies up to 18 months old.

Method
The study used a pragmatic pre-post intervention design. Outcomes were parental mental health, parenting confidence, quality of life, socio-emotional development of children, and perceived parent-child relationship. Fifteen groups representing n = 91 parent-baby dyads were recruited across the UK between 2017–2018. The sample consisted of 10 Mellow Mums groups (70 mother-baby dyads) and 5 Mellow Dads groups (21 father-baby dyads). Intention-to-treat and ‘completer’ analyses were performed.

Results
Findings suggest short-term positive outcomes for parents attending MB. Completion of the program was associated with significant improvements in anxiety and overall wellbeing, parenting confidence, and perceived closeness of the parent-child relationship. The significance of these improvements, except for parenting confidence, was maintained in the intention-to-treat analysis. MB engaged and retained a high proportion of parents who could be considered ‘at-risk’ and benefitted fathers and mothers attending the intervention equally.

Conclusions
This is the first prospective study to explore MB participation for both mothers and fathers and to indicate engagement and potential benefits specifically for ‘at-risk’ parents. Findings further demonstrate the effectiveness of MB as an early intervention program for parents experiencing psychosocial difficulties. Replication by studies using a contrast or control group also incorporating follow-up data would further improve the evidence base for MB.
Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study
Authors: Niriella Madunil Anuk , Ediriweera Dileepa Senajith , Kasturiratne Anuradhani , De Silva Shamila Thivanshi , Dassanayaka Anuradha Supun , De Silva Arjuna Priyadarshin , Kato Norihiro , Pathmeswaran Arunasalam , Wickramasinghe Ananda Rajitha , de Silva Hithanadura Janaka 
Published: February 2021

BackgroundThe term “metabolic (dysfunction)-associated fatty liver disease” (MAFLD) is suggested alternative for “non-alcoholic fatty liver disease” (NAFLD), as it better reflects metabolic dysfunction. No study has compared outcomes of the two diagnostic criteria.MethodsIn an ongoing, community-based, cohort-study in suburban Sri Lanka, participants were randomly selected in 2007. They were reassessed in 2014 to evaluate new-onset metabolic traits (MTs) and cardiovascular-events (CVEs). Baseline characteristics, MTs and CVEs after 7-years were compared in NAFLD and MAFLD and vs. controls. Similarly, we compared these parameters in those excluded by the NAFLD definition but captured by the MAFLD definition and vice versa, and vs. controls.FindingsOf 2985 recruited in 2007, 940 (31.5%) had NAFLD, 990 (33.1%) had MAFLD and 362 (12.1%) were controls. When compared to NAFLD, MAFLD captured an additional 2.9% and lost 1.3% individuals. At baseline, anthropometric and metabolic traits were similar in NAFLD and MAFLD. At follow-up in 7-years, the risk of having new-onset MTs and fatal/non-fatal CVEs were similar in the groups, but were significantly higher compared to controls. Those excluded by the NAFLD definition but captured by the MAFLD definition showed higher baseline MTs compared to those excluded by the MAFLD definition but captured by the NAFLD definition, and had substantially higher risk for having new-onset MTs and CVEs compared to controls.InterpretationAlthough NAFLD and MAFLD had similar MTs at baseline, and similar outcomes after 7-years, those who were excluded by the NAFLD definition but captured by the MAFLD definition seem at higher risk of adverse outcomes than those excluded by the MAFLD definition but captured by the NAFLD definition. Although the increase in the index population was small, redefining NAFLD as MAFLD seemed to improve clinical utility.
A systematic review and activation likelihood estimation meta-analysis of the central innervation of the lower urinary tract: Pelvic floor motor control and micturition
Authors: Groenendijk Ilse M. , Mehnert Ulrich , Groen Jan , Clarkson Becky D. , Scheepe Jeroen R. , Blok Bertil F. M. 
Published: February 2021

Purpose
Functional neuroimaging is a powerful and versatile tool to investigate central lower urinary tract (LUT) control. Despite the increasing body of literature there is a lack of comprehensive overviews on LUT control. Thus, we aimed to execute a coordinate based meta-analysis of all PET and fMRI evidence on descending central LUT control, i.e. pelvic floor muscle contraction (PFMC) and micturition.

Materials and methods
A systematic literature search of all relevant libraries was performed in August 2020. Coordinates of activity were extracted from eligible studies to perform an activation likelihood estimation (ALE) using a threshold of uncorrected p <0.001.

Results
20 of 6858 identified studies, published between 1997 and 2020, were included. Twelve studies investigated PFMC (1xPET, 11xfMRI) and eight micturition (3xPET, 5xfMRI). The PFMC ALE analysis (n = 181, 133 foci) showed clusters in the primary motor cortex, supplementary motor cortex, cingulate gyrus, frontal gyrus, thalamus, supramarginal gyrus, and cerebellum. The micturition ALE analysis (n = 107, 98 foci) showed active clusters in the dorsal pons, including the pontine micturition center, the periaqueductal gray, cingulate gyrus, frontal gyrus, insula and ventral pons. Overlap of PFMC and micturition was found in the cingulate gyrus and thalamus.

Conclusions
For the first time the involved core brain areas of LUT motor control were determined using ALE. Furthermore, the involved brain areas for PFMC and micturition are partially distinct. Further neuroimaging studies are required to extend this ALE analysis and determine the differences between a healthy and a dysfunctional LUT. This requires standardization of protocols and task-execution.
Hospital discharge data is not accurate enough to monitor the incidence of postpartum hemorrhage
Authors: Walther Diana , Halfon Patricia , Tanzer Romain , Burnand Bernard , Robertson Moira , Vial Yvan , Desseauve David , Le Pogam Marie-Annick 
Published: February 2021

Introduction
Postpartum hemorrhage remains a leading cause of maternal morbidity and mortality worldwide. Therefore, cumulative incidence of postpartum hemorrhage and severe postpartum hemorrhage are commonly monitored within and compared across maternity hospitals or countries for obstetrical safety improvement. These indicators are usually based on hospital discharge data though their accuracy is seldom assessed. We aimed to measure postpartum hemorrhage and severe postpartum hemorrhage using electronic health records and hospital discharge data separately and compare the detection accuracy of these methods to manual chart review, and to examine the temporal trends in cumulative incidence of these potentially avoidable adverse outcomes.

Materials and methods
We analyzed routinely collected data of 7904 singleton deliveries from a large Swiss university hospital for a three year period (2014–2016). We identified postpartum hemorrhage and severe postpartum hemorrhage in electronic health records by text mining discharge letters and operative reports and calculating drop in hemoglobin from laboratory tests. Diagnostic and procedure codes were used to identify cases in hospital discharge data. A sample of 334 charts was reviewed manually to provide a reference-standard and evaluate the accuracy of the other detection methods.

Results
Sensitivities of detection algorithms based on electronic health records and hospital discharge data were 95.2% (95% CI: 92.6% 97.8%) and 38.2% (33.3% to 43.0%), respectively for postpartum hemorrhage, and 87.5% (85.2% to 89.8%) and 36.2% (26.3% to 46.1%) for severe postpartum hemorrhage. Postpartum hemorrhage cumulative incidence based on electronic health records decreased from 15.6% (13.1% to 18.2%) to 8.5% (6.7% to 10.5%) from the beginning of 2014 to the end of 2016, with an average of 12.5% (11.8% to 13.3%). The cumulative incidence of severe postpartum hemorrhage remained at approximately 4% (3.5% to 4.4%). Hospital discharge data-based algorithms provided significantly underestimated incidences.

Conclusions
Hospital discharge data is not accurate enough to assess the incidence of postpartum hemorrhage at hospital or national level. Instead, automated algorithms based on structured and textual data from electronic health records should be considered, as they provide accurate and timely estimates for monitoring and improvement in obstetrical safety. Furthermore, they have the potential to better code for postpartum hemorrhage thus improving hospital reimbursement.
C-reactive protein reduction post treatment is associated with improved survival in atezolizumab (anti-PD-L1) treated non-small cell lung cancer patients
Authors: Patil Namrata S. , Zou Wei , Mocci Simonetta , Sandler Alan , Ballinger Marcus , Flynn Susan , Kowanetz Marcin , Hegde Priti S. 
Published: February 2021

Purpose
Overall survival (OS) is the most significant endpoint for evaluation of treatment benefit with checkpoint inhibitors (CPI) in cancer. We evaluated serum C-reactive protein (CRP) in non-small cell lung cancer (NSCLC) trials with atezolizumab (anti-PD-L1) as an early OS surrogate.

Methods
Serum from patients enrolled in randomized Phase II (n = 240) and Phase III (n = 701) trials of NSCLC patients (POPLAR, OAK) who progressed on prior-platinum chemotherapy, were analyzed for CRP levels over time. Patients were grouped by changes in CRP levels post-treatment as either increased (≥ 1.5 fold), decreased (≤ 1.5 fold) or unchanged (within +1.5 fold) relative to pre-treatment levels to assess association with progression free survival (PFS) and OS.

Results
Decrease in serum CRP levels at 6 weeks relative to pre-treatment were observed in patients with RECIST1.1 based complete or partial responses (CR/PR) to atezolizumab whereas patients with disease progression (PD) demonstrated an increase in CRP levels in the Phase II POPLAR study, and confirmed in the Phase III OAK study. Decrease in serum CRP as early as six weeks post treatment predicted improved PFS and OS, even in patients who were determined as stable disease (SD) in their first scan. This effect was not observed in the chemotherapy arms.

Conclusion
Modulation of serum CRP correlates with clinical outcome post-atezolizumab treatment. This routine lab test may provide utility in informing OS signals as early as 6 weeks post-initiation of therapy with CPIs in NSCLC.
The Effect of Caffeine on Athletic Performance
Authors: Hussain Nabeel 
Published: February 2021

Hypothesis:The intake of caffeine can increase physical performance during athletic activity
Methods:A search for primary sources was done using PubMed with MeSH terms. The search was limited to randomized controlled trials that were published between 2015 and 2020. After application of inclusion and exclusion criteria, seven articles were selected for this literature review.
Results:Of the seven randomized controlled trials selected, six demonstrated caffeine ingestion led to a statistically significant increase in physical performance. One of the randomized controlled trials found no statistically significant relationship between caffeine and run timings. The level set for statistical significance for this literature review was set to p < 0.05.Conclusion: With regards to the results of the selected studies, caffeine was shown to have ergogenic activity and was able to increase physical performance during exercise and sporting competition through multiple mechanisms. Further research should be done with greater sample sizes to determine the effect of rate of metabolism on caffeine activity and to compare caffeine responders and non-responders.