bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clients' Willingness to Incorporate Religion or Spirituality in Counseling
Authors: Diallo Abdoulaye , Herold Michael , Diallo Lara , Marini Irmo , Dominguez Allen 
Published: March 2021

PurposeThis study investigated clients' willingness to incorporate religion/spirituality in their counseling sessions.MethodsDescriptive statistics, logistic regression, and test of moderation were utilized in this study's data analyses.ResultsClients in general were willing to incorporate religion/spirituality in counseling sessions. Non-Christians were more willing than Christians. The relationship between clients' religion and their willingness occurred only in clients with a high level of spirituality.ConclusionRehabilitation educators should consider infusing religion/spirituality in their courses/curricula and encourage students to gain knowledge of various religion/spiritual beliefs in ways that provide a springboard for incorporating religion/spirituality in counseling.
Four years on the track of Callinectes sapidus (Rathbun, 1986): reconstructing the invasion of the Iberian Peninsula using social networks sites and citizen science.
Authors: Gomez David Izquierdo 
Published: March 2021

Abstract
Callinectes sapidus (Rathbun, 1896) is one of the 100 worst alien invasive species in the Mediterranean Sea, first reported in Venice in 1949. Firstly, the portunid crab colonized the Northern Levantine basin, and half a century later the species spreads rapidly in the Western basin. The general use of social network sites and smart phones have derived in the bloom of citizen science, which enlists the general public in gathering scientific information across large spatio-temporal scales. This research, describes the use of citizen science to unveil the colonization of C. sapidus in the Iberian Peninsula, using the Local Ecological Knowledge of recreational fishermen. Overall, C. sapidus has been detected in more than 300 locations, including a number of Natura2000 areas and 18 rivers. Eventually, recreational fishermen perceived the presence of the portunid crab as detrimental for the ecosystem.
Evaluation of Prognostic Value of Serum Matrix Metalloproteinases (MMP)-2 and MMP-9 in Canine Mammary Gland Tumors; A Longitudinal Study
Authors: Khaki Zohreh , Fathipour vahid 
Published: March 2021

Abstract
Background: Serum levels of MMP-2 and MMP-9 were evaluated in 26 dogs with mammary tumors before surgical treatment and then 1, 4 and 12 months after surgery by gelatin zymography. Serum samples from 26 dogs with the normal condition were used as the control in the zymographic evaluation. In addition, pathology evaluation was performed in patients. Results: Our results showed that lymph node metastases are risk factor for death and metastasis and or recurrence (M/R) in canine malignant mammary tumors. Dogs with benign and malignant mammary tumors showed bands of Pro-MMP-2, Pro-MMP-9 and active MMP-9 with molecular weights of 72, 92 and 82, respectively. However, only Pro-MMP-2 and Pro-MMP-9 bands appeared in the serum of control group and two patients with benign lobular hyperplasia tumor. Our results showed that Pro-MMP-2 levels increased more dramatically (2 fold) in malignant tumors than in benign tumors and control groups. Also, in patients with M/R, there was a significant increase in the levels of Pro-MMP-9 in serum samples 12 months after surgery compared with other sampling times. Meanwhile, the presence of active MMP-9 (especially in samples 4 and 12 months after surgery of malignant tumors), regardless of its amount, is important in terms of prognosis for recurrence or metastasis. Also, active MMP-2 was only detected in some malignant and metastatic tumors. Observation of active MMP-2 band is very important for M/R than active MMP-9 because its presence regardless of values coincides with a definite M/R, unlike the active form of MMP-9. Necrosis, stromal invasion, and infiltrative growth increase risk of the development of M/R and the presence of necrosis is a risk factor for death. Conclusions: In conclusion, serum zymograhpy may be used at regular intervals after surgery to check for the possibility of M/R in dogs with mammary tumors.More research is needed in this regard.
Preliminary Assessment of Air Pollution Quality Levels of Lagos, Nigeria
Authors: Abulude Francis Olawale , Damodharan Usha , Acha Sunday , Adamu Ademola , Arifalo Kikelomo Mabinuola 
Published: March 2021

Abstract
The low-cost sensors and IoT have come to the rescue due to the high cost and operational complexity of equipment and methodologies in environmental monitoring. They are relatively inexpensive and reliable. It is on this assumption that we have decided to use the World Air Quality satellite data supplied by air matters.com. This study is a 40-day preliminary work in which air quality (Air Quality Index (AQI), PM2.5, PM10, NO2, CO, SO2, and O3) and meteorological (temperature, humidity, and wind speed) parameters were monitored. The data collected was for five locations in Lagos State, Nigeria (Ojodu, Opebi, Ikeja, Maryland, and Eti-Osa). The data obtained were subjected to basic statistical analyses. The findings showed that the Opebi had the highest mean value of PM2.5 (69.28 µg/m3), PM10 (107.38 µg/m3), and CO (1392 µg/m3). The mean values of O3 are as follows: 32.52, 38.7, 36.2, 37.85, and 36.13µg/m3 for Ikeja, Maryland, Opebi, Ojodu, and Eti-Osa respectively. Opebi had the highest value (3179µg/m3), followed by Eti-Osa (2978µg/m3), and the lowest value in Maryland (1943µg/m3) among the CO reference locations. AQI of all locations presented the levels of contamination as 'Unhealthy for Vulnerable Groups'. The pollutants were much higher than the World Health Organization (WHO) guidelines. There were relationships between the parameters monitored and meteorological influences, and the effects of natural and man-made activities may be the sources of the elevated pollutants throughout the locations.
Patient Transfers and Clostridioides Difficile Infections: A Case-Control Study
Authors: Edman-Wallér Jon , Suominen Sakari , Jacobsson Gunnar , Werner Maria 
Published: March 2021

Abstract
Background

Clostridioides difficile spores are present in the hospital environment. We hypothesized that patient transfers between rooms is an independent risk factor for C. difficile infections (CDI), as this increases the environmental exposition. We performed a retrospective case-control study at a public 400-bed hospital in western Sweden.
Methods

Hospital-acquired CDI cases at Södra Älvsborg Hospital, Sweden, during two different years (n = 65) were included in the case group. A random, unmatched selection of patients tested negative for CDI served as control group (n = 101). The number of rooms each patient occupied during hospitalization was the primary variable. Odds ratios (OR) for CDI were calculated by simple and multiple logistic regression.
Results

The number of rooms occupied was not an independent risk factor (OR per room 1.1, 95 % CI: 0.8–1.4) when data were adjusted for duration of hospitalization, which was the only statistically significant variable (OR per additional week of care: 1.7, 95 % CI: 1.2–2.3) in the multiple logistic regression model. The risk associated with the duration of hospitalization was larger among patients who stayed in four or more rooms (OR per additional week of care: 2.5, 95 % CI: 1.1–5.6) than among patients that stayed in one room only (OR per additional week of care: 1.3, 95 % CI: 0.7–2.4).
Conclusions

The risk for C. difficile infections increase with time of care, and patient transfers might amplify the risk, although we could not prove it to be an independent risk factor in this limited case-control study.
Dissipative and Generative Fractional Electric Elements in Modeling RC&nbsp;and RL&nbsp;Circuits
Authors: Haška Kristian , Cvetićanin Stevan , Zorica Dušan 
Published: March 2021

Abstract
Generalized capacitor (inductor) is constitutively modeled by expressing charge (magnetic flux) in terms of voltage (current) memory as a sum of instantaneous and power type hereditary contributions and it is proved to be a dissipative electric element by thermodynamic analysis. On the contrary, generalized capacitor (inductor) as a generative electric element is modeled using the same form of the constitutive equation, but by expressing voltage (current) in terms of charge (magnetic flux) memory. These constitutive models are used in transient and steady state regime analysis of the series RC and RL circuits subject to electromotive force, as well as in the study of circuits' frequency characteristics including asymptotic behavior.
A Time-Zero Biomechanical Study of the Effective Length of the Graft in Posterior Cruciate Ligament Reconstruction
Authors: Teng Fei , Teng Yuanjun , Lu Fan , Zhang Xiaohui , Liu Zhongcheng , He Liangzhi , Wang Hong , Han Hua , Xia Yayi 
Published: March 2021

Abstract
Background The effect of effective length on the biomechanical properties of the graft is regarded as an essential variable influencing the posterior cruciate ligament reconstruction. However, the effect has not been fully studied. The purpose was to compare the effects of different effective graft lengths (35 mm, 55 mm, 65 mm) on the time-zero biomechanical properties of the graft in posterior cruciate ligament (PCL) reconstruction.Methods Bovine digital flexor tendons and porcine tibias were used to establish in-vitro PCL reconstruction models. Tensile strength testing was performed at 3 different effective lengths of the graft: short (35 mm, n = 10, group 1), medium (55 mm, n = 10, group 2), and long (65 mm, n = 10, group 3). A computer software (Trapezium X; Shimadzu) was used to record the load-elongation curve, ultimate load (N), the elongation of the graft during the test (mm), tensile stiffness (N/mm), and energy absorption (J). The failure pattern was evaluated by visual observation.Results All the samples failed because the grafts slipped out from the bones, except two grafts ruptured in group 1. The tensile stiffness and ultimate load in group 1 were significantly higher than those in group 2 and group 3 (tensile stiffness, 50.49 ± 11.43 N/mm in group 1 vs 31.20 ± 10.44 N/mm in group 2[P < 0.001] and 19.18 ± 6.18 N/mm in group 3 [P < 0.001]; ultimate load, 452.40 ± 54.52 N in group 1 vs 338.50 ± 26.79 N in group 2 [P < 0.001]and 268.70 ± 28.30 N in group 3 [P < 0.001]). There were significant differences between group 1 and group 3 in energy absorption(9.61 ± 3.25 J vs 5.22 ± 2.43 J, P = 0.002). At 50 N and 100 N of applied load, no statistically significant differences were detected on the elongation of the grafts (P > 0.05). The elongation of the short grafts under 150 N and 200 N of applied load was significantly less than that of the long grafts (150 N, 1.77 ± 0.83 mm in group 1 vs 4.14 ± 1.75 mm in group 3, P = 0.047; 200 N, 2.62 ± 1.10 mm in group 1 vs 7.06 ± 3.20 mm in group 3, P = 0.006).Conclusions This study demonstrated the time-zero biomechanical properties of the graft with short effective length were superior to those of the graft with medium and long effective lengths in PCL reconstruction.
High-performance tapered fiber surface plasmon resonance sensor based on graphene/Ag/TiO2 layer
Authors: Wang Dan , Li Wei , Zhang Qingrong , Liang Benquan , Peng Zhenkai , Xu Jie , Zhu Chen , Li Jinze 
Published: March 2021

Abstract
In this paper, a highly sensitive surface plasmon resonance sensor is proposed on the basis of a miniature tapered single-mode fiber. The sensing area of the tapered fiber is coated with graphene, silver and titanium dioxide layer. The graphene layer is used to increase the light absorption rate, and the titanium dioxide layer is used to protect the silver layer from oxidation and improve the sensor sensitivity due to its high dielectric constant. And optimizing the thickness of graphene, silver and titanium dioxide layer. According to the simulation calculation results, when the graphene is 15 layers, the silver layer is 40 nm, and the titanium dioxide is 20 nm, high-performance SPR can be obtained. The sensor has a detection range of 1.32–1.38, and its sensitivity can reach 8750 nm/RIU when the external refractive index is 1.38. The research results have potential application value for the design of high-performance SPR sensors.
Prognostic model of head and neck squamous cell carcinoma based on 12 ferroptosis-related genes
Authors: Li Sijia , Zhang Hongyang , Li Wei 
Published: March 2021

Abstract
Background: The purpose of our study is establishing a model based on ferroptosis-related genes predicting the prognosis of patients with head and neck squamous cell carcinoma (HNSCC).Methods: In our study, transcriptome and clinical data of HNSCC patients were from The Cancer Genome Atlas, ferroptosis-related genes and pathways were from Ferroptosis Signatures Database. Differentially expressed genes (DEGs) were screened by comparing tumor and adjacent normal tissues. Functional enrichment analysis of DEGs, protein-protein interaction network and gene mutation examination were applied. Univariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) regression were used to identified DEGs. The model was constructed by multivariate Cox regression analysis and verified by Kaplan-Meier analysis. The relationship between risk scores and other clinical features was also analyzed. Univariate and multivariate Cox analysis was used to verified the independence of our model. The model was evaluated by receiver operating characteristic analysis and calculation of the area under the curve (AUC). A nomogram model based on risk score, age, gender and TNM stages was constructed.Results: We analyzed data including 500 tumor tissues and 44 adjacent normal tissues and 259 ferroptosis-related genes, then obtained 73 DEGs. Univariate Cox regression analysis screened out 16 genes related to overall survival, and LASSO analysis fingered out 12 of them with prognostic value. A risk score model based on these 12 genes was constructed by multivariate Cox regression analysis. According to the median risk score, patients were divided into high-risk group and low-risk group. The survival rate of high-risk group was significantly lower than that of low-risk group in Kaplan-Meier curve. Risk scores were related to T and grade. Univariate and multivariate Cox analysis showed our model was an independent prognostic factor. The AUC was 0.669. The nomogram showed high accuracy predicting the prognosis of HNSCC patients.Conclusion: Our model based on 12 ferroptosis-related genes performed excellently in predicting the prognosis of HNSCC patients. Ferroptosis-related genes may be promising biomarkers for HNSCC treatment and prognosis.
Effects of Tool Wear on Machined Surface Integrity During Milling of Inconel 718
Authors: Tan Liang , Yao Changfeng , Zhang Dinghua , Cui Minchao , Shen Xuehong 
Published: March 2021

Abstract
This paper investigates the effects of tool wear on the machined surface integrity characteristics, including the surface roughness, surface topography, residual stress, microhardness and microstructure, during ball-end milling of Inconel 718. Tool wear, tool lifetime, and cutting force are measured. In addition, a two-dimensional finite element-based model is developed to investigate the cutting temperature distribution in the chip–tool–workpiece contact area. Results show that the ball nose end mill achieves tool lifetime of approximately 350 min. The cutting forces increase sharply with a greater tool flank wear width, while the highest cutting temperature has a decreasing tend at a flank wear width of 0.3 mm. Higher tool flank wear width produces larger surface roughness and deteriorative surface topography. A high-amplitude (approximately −700 MPa) and deep layer (approximately 120 mm) of compressive residual stress are induced by a worn tool with 0.3 mm flank wear width. The surface microhardness induced by new tool is larger than that induced by worn tool. Plastic deformation and strain streamlines are observed within 10 mm depth beneath the surface. The results in this paper provide an optimal tool wear criterion which integrates the surface integrity requirements and the tool lifetime for ball-end finish milling of Inconel 718.
Identification CXCL9 is a Potential Prognostic Biomarker in Ovarian and Gastric Cancer and is Correlated with Immune Infiltrates
Authors: Wu Tinghui , Li Yongchao , Gong Shujuan , Shi Ruijun , Zhou Hangzheng , Wang Dongyang , Zhu Kunlong , Xue Shenglong , Zhang Jianpei , Li Shuwei 
Published: March 2021

Abstract
Background

CXCL9 also known as an interferon gamma-inducible chemokine that belonging to the CXC chemokine family. It plays a role in promoting chemotaxis, inducing leukocyte differentiation and multiplication, and triggering tissue extravasation.
Methods

The TIMER (Tumor Immune Estimation Resource) and cancer microarray database Oncomine were used to dig at CXCL9 expression. The clinic prognostic level of CXCL9 was evaluated via Kaplan-Meier plotter. Then, Using TIMER and GEPIA, we investigated whether CXCL9 expression impacted cancer immune infiltrates.
Results

CXCL9 expression has been found to be significantly lower in ovarian and gastric cancers relative to normal tissues. In patients with ovarian cancer (OS HR = 0.78, P = 0.0017; PFS HR = 0.85, R = 0.015) and gastric cancer (OS HR = 0.55, P = 1.1e-08; PFS HR = 0.58, R = 7.6e-07), low CXCL9 expression was correlation to PFS (progression-free survival) and OS (poor overall survival). Furthermore, in OV and GC, CXCL9 was shown to have a close interaction with tumor-infiltrating immunity cells (B cells, CD4 + and CD8 + T cells, macrophages, neutrophils, and dendritic cells). CXCL9 expression, on the other hand, was shown to be closely related to several immune markers.
Conclusion

In OV and GC, CXCL9 mRNA level is strongly associated with prognosis and levels of penetration tumor-infiltrating immunity cell. The CXCL9 expression may also play a role in controlling TAMs (tumor-associated macrophages), DCs (Dendritic cells), CTLs (cytotoxic lymphocytes), and NK (natural killer) cells in OV and GC. CXCL9 may be seen as an independent marker that assesses the prognosis in OV and GC patients. Besides, CXCL9 expression level also can assess the immune cell subtypes of tumor microenvironment in OV and GC.
Multi-rogue Wave Solutions for a Generalized Integrable Discrete Nonlinear Schrodinger Equation With Higher-order Excitations
Authors: Li-Yuan Ma , Jun Yang , Yan-Li Zhang 
Published: March 2021

Abstract
In this paper, we construct the discrete rogue wave(RW) solutions for a higher-order or generalized integrable discrete nonlinear Schr¨odinger(NLS) equation. First, based on the modified Lax pair, the discrete version of generalized Darboux transformation are constructed. Second, the dynamical behaviors of first-, second- and third-order RWsolutions are investigated in corresponding to the unique spectral parameter λ, higher-order term coefficient γ, and free constants dk, fk (k = 1, 2, · · · ,N), which exhibit affluent wave structures. The differences between the RW solution of the higher-order discrete NLS equation and that of the Ablowitz-Ladik(AL) equation are illustrated in figures. Moreover, numerical experiments are explored, which demonstrates that strong-interaction RWs are stabler than the weak-interaction RWs. Finally, the modulation instability of continuous waves is studied.
Coronaviruses exploit a host cysteine-aspartic protease for efficient replication
Authors: Yuen Kwok-Yung , Chu Hin , Hou Yuxin , Yang Dong , Wen Lei , Shuai Huiping , Yuen Terrence Tsz-Tai , Li Cun , Zhao Xiaoyu , Wang Yixin , Hu Bingjie , Huang Xiner , Chai Yue , Yoon Chaemin , Cai Jian-Piao , Poon Vincent , Chan Chris , Zhang Jinxia , Yuan Shuofeng , Sit Ko-Yung , Foo Dominic Chi-Chung , Au Wing-Kuk , Wong Kenneth Kak-Yuen , Zhou Jie , Kok Kin-Hang , Jin Dong-Yan , Chan Jasper 
Published: March 2021

Abstract
Highly pathogenic coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1,2, Middle East respiratory syndrome coronavirus (MERS-CoV)3,4, and SARS-CoV-15 vary in their transmissibility and pathogenicity. However, infection by all three viruses result in substantial apoptosis in cell culture6-8 and in patient samples9-11, suggesting a potential link between apoptosis and the pathogenesis of coronaviruses. To date, the underlying mechanism of how apoptosis modulates coronavirus pathogenesis is unknown. Here we show that a cysteine-aspartic protease of the apoptosis cascade, caspase-6, serves as an essential host factor for efficient coronavirus replication. We demonstrate that caspase-6 cleaves coronavirus nucleocapsid (N) proteins, generating N fragments that serve as interferon (IFN) antagonists, thus facilitating virus replication. Inhibition of caspase-6 substantially attenuates the lung pathology and body weight loss of SARS-CoV-2-infected golden Syrian hamsters and improves the survival of mouse-adapted MERS-CoV (MERS-CoVMA)-infected human DPP4 knock-in (hDPP4 KI) mice. Overall, our study reveals how coronaviruses exploit a component of the host apoptosis cascade to facilitate their replication. These results further suggest caspase-6 as a potential target of intervention for the treatment of highly pathogenic coronavirus infections including COVID-19 and MERS.
Mechanical circulatory support for refractory out-of-hospital cardiac arrest: A Danish nationwide multicentre study
Authors: Mørk Sivagowry Rasalingam , Stengaard Carsten , Linde Louise , Møller Jacob Eifer , Jensen Lisette Okkels , Schmidt Henrik , Riber Lars Peter , Andreasen Jo Bønding , Thomassen Sisse Anette , Laugesen Helle , Freeman Phillip Michael , Christensen Steffen , Greisen Jacob Raben , Tang Mariann , Møller-Sørensen Peter Hasse , Holmvang Lene , Gregers Emilie Sarah Tofte , Kjaergaard Jesper , Hassager Christian , Eiskjær Hans , Terkelsen Christian Juhl 
Published: March 2021

Abstract
Background
Extracorporeal cardiopulmonary resuscitation (ECPR) has shown potential as a salvage therapy for patients with refractory out-of-hospital cardiac arrest (OHCA). The objective of this study was to to describe the gradual implementation, survival and adherence to the national consensus with respect to use of ECPR for OHCA in Denmark, and to identify factors associated with outcome.
Methods
This retrospective, observational cohort study included patients receiving ECPR for OHCA at all tertiary cardiac arrest centers (n = 4) in Denmark between July 2011 and December 2020. Logistic regression and Kaplan-Meier survival analysis were used to determine association with outcome. Outcome was presented as survival to hospital discharge with good neurological outcome, 30-day survival and predictors of 30-day survival.
Results
A total of 259 patients were included in the study. Thirty-day survival was 26% and a good neurological outcome (Glasgow-Pittsburgh Cerebral Performance Categories (CPC) (CPC 1–2)) was observed in 94% of patients at discharge. Strict adherence to the national consensus showed a 30-day survival rate of 30% compared with 22% in patients violating one or more criteria. Adding criteria to the national consensus such as signs of life during cardiopulmonary resuscitation (CPR), pre-hospital low-flow < 100 minutes, pH > 6.8 and lactate < 15 mmol/L increased the survival rate to 48%, but would exclude 58% of the survivors from the current cohort. Logistic regression identified asystole (RR 1.36, 95% CI 1.18–1.57), pulseless electrical activity (RR 1.20, 95% CI 1.03–1.41), initial pH < 6.8 (RR 1.28, 95% CI 1.12–1.46) and lactate levels > 15 mmol/L (RR 1.16, 95% CI 1.16–1.53) as factors associated with increased risk of 30-day mortality. Patients presenting signs of life during CPR had a threefold higher survival rate compared to patients without signs of life (45% versus 13%, p < 0.001).
Conclusions
A high survival rate with a good neurological outcome was observed in this Danish population of patients treated with ECPR for OHCA. Stringent patient selection for ECPR may produce higher survival rates but potentially withholds life-saving treatment in a significant proportion of survivors, why optimization of the selection criteria is still necessary.