bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of H2S Supplementation on Burn Wound Healing and Molecular Chaperones
Authors: Verma Saurabh , Keshri Gaurav K. , Sharma Manish , Gupta Asheesh 
Published: June 2021

Treatment of non-healing burn injuries is a major challenge for the current scientific research. Hydrogen sulfide (H2S) is an endogenous gasotransmitter, which regulates redox homeostasis and cytoprotection during pathophysiological conditions. Similarly, heat shock proteins (HSPs) are molecular chaperones, which also confer cytoprotection during the wound repair process. Notably, the role of H2S as a regulator of HSPs during burn wound healing is still elusive. The present study investigated the effects of H2S supplementation on molecular chaperones during full-thickness, third-degree burn wound healing in the experimental rats. The animals were treated with sodium hydrosulphide (NaHS) as H2S donor (5 mg/kg body weight, intraperitoneal) daily for 10 days prior to burn-induction and continued till the fifth-day post-wounding. Histopathological analysis (Masson’s trichrome) revealed enhanced wound healing evident by increased collagen fiber deposition, cellular proliferation and re-epithelialisation in NaHS administered group as compared to the burn control. Furthermore, immunoblot analyses demonstrated significantly increased protein expression of molecular chaperons viz. HSP90, HSP70, HSP27, and GRP78 in H2S treated group as compared to control. Therefore, the present study signifies that H2S supplementation upregulates the protein expression levels of molecular chaperones, which could facilitate the cytoprotection during the tissue repair process and accelerates the burn wound healing.
The versatility of external quality assessment for the surveillance of laboratory and in vitro diagnostic performance: SARS-CoV-2 viral genome detection in Austria
Authors: Buchta Christoph , Camp Jeremy V. , Jovanovic Jovana , Chiba Peter , Puchhammer-Stöckl Elisabeth , Mayerhofer Maximilian , Plicka Helga , Lercher Alexander , Popa Alexandra M. , Endler Lukas , Bergthaler Andreas , Huf Wolfgang , Benka Bernhard , Delatour Vincent , Müller Mathias M. , Griesmacher Andrea , Aberle Stephan W. , Görzer Irene 
Published: June 2021

Abstract

Objectives
External quality assessment (EQA) schemes provide information on individual and general analytical performance of participating laboratories and test systems. The aim of this study was to investigate the use and performance of SARS-CoV-2 virus genome detection systems in Austrian laboratories and their preparedness to face challenges associated with the pandemic.

Methods
Seven samples were selected to evaluate performance and estimate variability of reported results. Notably, a dilution series was included in the panel as a measure of reproducibility and sensitivity. Several performance criteria were evaluated for individual participants as well as in the cohort of all participants.

Results
A total of 109 laboratories participated and used 134 platforms, including 67 different combinations of extraction and PCR platforms and corresponding reagents. There were no false positives and 10 (1.2%) false negative results, including nine in the weakly positive sample (C

t
∼35.9, ∼640 copies/mL). Twenty (22%) laboratories reported results of mutation detection. Twenty-five (19%) test systems included amplification of human RNA as evidence of proper sampling. The overall linearity of C

t
values from individual test systems for the dilution series was good, but inter-assay variability was high. Both operator-related and systematic failures appear to have caused incorrect results.

Conclusions
Beyond providing certification for participating laboratories, EQA provides the opportunity for participants to evaluate their performance against others so that they may improve operating procedures and test systems. Well-selected EQA samples offer additional inferences to be made about assay sensitivity and reproducibility, which have practical applications.
Using body temperature and variables commonly available in the EHR to predict acute infection: a proof-of-concept study showing improved pretest probability estimates for acute COVID-19 infection among discharged emergency department patients
Authors: Berdahl Carl T. , Nguyen An T. , Diniz Marcio A. , Henreid Andrew J. , Nuckols Teryl K. , Libby Christopher P. , Pevnick Joshua M. 
Published: June 2021

Abstract

Objectives
Obtaining body temperature is a quick and easy method to screen for acute infection such as COVID-19. Currently, the predictive value of body temperature for acute infection is inhibited by failure to account for other readily available variables that affect temperature values. In this proof-of-concept study, we sought to improve COVID-19 pretest probability estimation by incorporating covariates known to be associated with body temperature, including patient age, sex, comorbidities, month, and time of day.

Methods
For patients discharged from an academic hospital emergency department after testing for COVID-19 in March and April of 2020, we abstracted clinical data. We reviewed physician documentation to retrospectively generate estimates of pretest probability for COVID-19. Using patients’ COVID-19 PCR test results as a gold standard, we compared AUCs of logistic regression models predicting COVID-19 positivity that used: (1) body temperature alone; (2) body temperature and pretest probability; (3) body temperature, pretest probability, and body temperature-relevant covariates. Calibration plots and bootstrap validation were used to assess predictive performance for model #3.

Results
Data from 117 patients were included. The models’ AUCs were: (1) 0.69 (2) 0.72, and (3) 0.76, respectively. The absolute difference in AUC was 0.029 (95% CI −0.057 to 0.114, p=0.25) between model 2 and 1 and 0.038 (95% CI −0.021 to 0.097, p=0.10) between model 3 and 2.

Conclusions
By incorporating covariates known to affect body temperature, we demonstrated improved pretest probability estimates of acute COVID-19 infection. Future work should be undertaken to further develop and validate our model in a larger, multi-institutional sample.
In and Out of Self-Employment, Are You Really an Entrepreneur: The Rise of a New Division?
Authors: Hussein Hiba Maher , Haj Youssef Moustafa Salman 
Published: June 2021

AbstractThis paper examines self-employed individuals in the UK Labour market. We use an amalgamated dataset, the British Household Panel Survey, from the years 1991 to 2008, and its successor the United Kingdom Longitudinal Study, from years 2010 to 2014, following 11,657 respondents in the UK for 23 years. We explore the characteristics of different self-employed groups and create a new division that differentiates those who sustain in self-employment from those who move between self-employment and employee jobs. The sample size consists of 1146 sustained self-employed, 1149 dabbled self-employed and 9362 paid workers. We found that dabblers exhibit unique set of attributes that place them in a distinct position compared to sustained self-employed and/or employees. Dabblers seem to be ‘pulled’ rather than ‘pushed’ into self-employment, reflecting a labour market ‘power’ instead of deficiency. Thus, bringing key insight into a group who have not been separately identified in the labour market to date, the self-employed dabblers.
Microstructure and mechanical properties of 2060 Al–Li alloy welded by alternating current cold metal transfer with high-frequency pulse current
Authors: Wang Liwei , Hu Huan , Yan Huan , Liu Ying , Wu Ziqin , Narayanaswamy Balaji , Liang Zhimin , Wang Dianlong 
Published: June 2021

AbstractAl–Li alloy has been widely used in the aerospace field owing to its high strength and low density. In this study, alternating current cold metal transfer (AC CMT) along with a high-frequency pulse current technique was used to weld a 2060 Al–Li alloy using an ER5356 wire. The effect of pulse frequency on the arc shape, microstructure, and mechanical properties of the welded joints was examined, and mechanical performance testing was conducted. The results revealed that the arc diameter, arc length, and arc volume showed a trend of increasing first and then decreasing with an increase in the pulse frequency and reached their peak values when the pulse frequency was 50 kHz. Coupling the welding process with a high-frequency pulse resulted in grain refinement, which was attributed to the stirring action of the arc force. Both the porosity levels and grain size decreased with increasing frequency. When the pulse frequency was 70 kHz, the porosity level was the lowest, and the grain size was refined to 24.1 μm. The tensile strength of the welded joints also increased with the pulse frequency, and a maximum tensile strength of 249 MPa was observed at 70 kHz.
Neonatal maple syrup urine disease in China: two novel mutations in the BCKDHB gene and literature review
Authors: Jiang Hong‐Hua , Guo Yan , Shen Xian , Wang Ying , Dai Ting-Ting , Rong Hui , Cheng Rui , Zhao Fei 
Published: June 2021

Abstract

Objectives
To report two novel mutations in the BCKDHB gene with Maple syrup urine disease (MSUD) and compare their data with 52 cases of MSUD reported in the available Chinese literature.

Methods
Clinical data of a case of a newborn with MSUD was retrospectively studied. Literatures on MSUD in the local medical journals from January 1990 till December 2019 in China were reviewed.

Results
Two novel BCKDHB mutations c.90_91insCTGGCGCGGGG (p.Phe35TrpfsTer41) and c.80_90del (p.Ala32PhefsTer48) were identified. We found a total of 52 cases of MSUD reports so far. A total of 49 cases had the symptom of poor feeding (94.2%), 50 cases showed poor responses to stimulation (96.2%), 21 cases had odor of maple syrup (40.3%), 29 cases had seizures (55.7%), and 13 cases had respiratory failure (25.0%). The average of the blood ammonia was 127.2 ± 75.0 μmol/L. A total of 18 cases reported the gene testing, among of them 9 cases of BCKDHA mutations, 6 cases of BCKDHB mutations, and 2 cases of DBT mutations. A total of 13 cases (25%) were treated with mechanical ventilation, 50 cases (96.2%) with protein-restricted diet and l-carnitine, 29 cases with thiamine, and only 2 cases were treated with blood purification. Finally, 19 patients (36.5%) were died, 21 cases (40.4%) were improved after treatments.

Conclusions
The clinical phenotype of neonatal MSUD in China belongs to the classical type currently. Suspected patients should have blood or urine branched-chain amino acid levels tested and brain MRI as early as possible to enable early diagnosis, thus improvement in prognosis.
Crystal structure of methyl 2-(1H-naphtho[1,8-de][1.3.2]diazaborinin-2(3H-yl)benzoate C18H15BN2O2
Authors: Song Wenqi , Miao Zongcheng 
Published: June 2021

Abstract
C18H15BN2O2, monoclinic, C2/c (no. 15), a = 23.976(3) Å, b = 7.7690(9) Å, c = 32.940(4) Å, β = 95.17(1)°, V = 2482.26(15) Å3, Z = 4, R

gt
(F) = 0.0525, wR

ref
(F
2) = 0.1415, T = 193 K.
The crystal structure of bis[4-bromo-2-(1H-pyrazol-3-yl) phenolato-κ2
N,O] copper(II), C18H12Br2CuN4O2
Authors: Jaćimović Željko K. , Tomić Zoran D. , Giester Gerald , Libowitzky Eugen , Ajanović Atifa , Kosović Milica 
Published: June 2021

Abstract
C18H12Br2CuN4O2, monoclinic, P21/c (no. 14), a = 11.5165(11) Å, b = 5.4369(5) Å, c = 14.4872(14) Å, V = 873.52(14) Å3, Z = 2, R

gt
(F) = 0.0232, wR

ref
(F
2) = 0.0559, T = 200 K.
Carbonyl pigments: General principles
Authors: Christie Robert , Abel Adrian 
Published: June 2021

AbstractThis chapter describes the general features of the chemical class of pigments designated as carbonyl pigments. These pigments are characterized by the presence of carbonyl groups linked to one another via an extended conjugated system, often forming polycyclic aromatic structures. Carbonyl pigments have experienced distinct phases in their histories. Certain carbonyl colorants, notably anthraquinonoids, were discovered in the early twentieth century and subsequently used as vat dyes for textiles, but their potential as high-performance pigments was not realized until the mid-twentieth century when demand began to emerge for pigments of the quality that they could provide. After conversion to a suitable physical form, several vat dyes were then introduced as vat pigments. Several other carbonyl pigment types did not originate as vat dyes but were developed specifically for pigment use. Carbonyl pigments provide a wider diversity of structural arrangements. The broad carbonyl chemical class may be categorized into several sub-types, each with its own characteristic structural features. These categories, which are discussed in separate chapters, include anthraquinonoids, quinacridones, diketopyrrolopyrroles, perylenes, perinones, indigoids, isoindolines, isoindolinones, and quinophthalones. These products generally owe their high levels of technical performance to their large molecular size and high molecular planarity, which lead to highly compact crystal structures and, in many cases, to the ability of the carbonyl group to participate in strong intra- and intermolecular hydrogen bonding.
Phthalocyanine pigments: general principles
Authors: Christie Robert , Abel Adrian 
Published: June 2021

AbstractThis chapter describes some of the fundamental chemical and structural principles underlying the phthalocyanine system. Historically, phthalocyanines had been isolated as insoluble blue products in the early twentieth century, although the structures were not established at the time. After the serendipitous re-discovery of metal complex phthalocyanines by industry, and the elucidation of their structures, copper phthalocyanine (CuPc) pigments were introduced industrially in the 1930s to become, and remain, by far the most important blue and green organic pigments, finding almost universal use as colorants for paints, printing inks, plastics, and a wide range of other applications. The phthalocyanines have become one of the most extensively studied classes of organic compounds, because of their unique molecular structures, light absorption properties that produce strong, bright colors, and their exceptionally high stability. While their dominant use is as colorants, they are also of interest for a range of other applications, for example in electronic devices, biological applications, and as catalysts.
Nonlinear forced vibration of rotating composite laminated cylindrical shells under hygrothermal environment
Authors: Li Xiao , Jiang Wentao , Chen Xiaochao , Zhou Zhihong 
Published: June 2021

Abstract
This work aims to study nonlinear vibration of rotating composite laminated cylindrical shells under hygrothermal environment and radial harmonic excitation. Based on Love’s nonlinear shell theory, and considering the effects of rotation-induced initial hoop tension, centrifugal and Coriolis forces, the nonlinear partial differential equations of the shells are derived by Hamilton’s principle, in which the constitutive relation and material properties of the shells are both hygrothermal-dependent. Then, the Galerkin approach is applied to discrete the nonlinear partial differential equations, and the multiple scales method is adopted to obtain an analytical solution on the dynamic response of the nonlinear shells under primary resonances of forward and backward traveling wave, respectively. The stability of the solution is determined by using the Routh–Hurwitz criterion. Some interesting results on amplitude–frequency relations and nonlinear dynamic responses of the shells are proposed. Special attention is given to the combined effects of temperature and moisture concentration on nonlinear resonance behavior of the shells.
Outras hegemonias em pesquisas sobre currículos transnacionais
Authors: Silva Maria da Graça Moreira da , Almeida Fernando José , Rupp Lucila 
Published: June 2021

Este artigo busca destacar dentro do cenário atual de pesquisas sobre currículo dos países do Mercosul concepções curriculares contra hegemônicas aos modelos imperantes a fim de apontar outras possíveis epistemologias que se afastem do neoliberalismo. A pergunta central do artigo pode assim ser resumida: O que é ser contra-hegemônico, ou o que é o “outro” frente às epistemologias neoliberais? Dessa pergunta, surgem outras e, para responder a tais perguntas, o trajeto pelos currículos de quatro países do Mercosul destacou peças desse mosaico, que evidenciou formas diferenciadas para que os jovens possam conhecer e diagnosticar o próprio território. Para tanto, combina a análise dos documentos curriculares dos países Argentina, Paraguai, Uruguai e Venezuela (Mercosul) com produções científicas relacionadas ao tema, identificando a presença e valorização de temas latino-americanos e sul-americanos nesses textos. Os dados coletados e analisados revelam que os currículos investigados apontam, explicitamente, a intencionalidade da construção de uma identidade sul-americana ou latino-americana, apresentando uma combinação entre temáticas universais e abordagem regionalista, incorporando aprendizagens ligadas ao Mercosul e à América Latina.
Infant swimming: a contribution to children’s health
Authors: Sapozhnikova O. V. 
Published: June 2021

Nowadays, infant swimming is a rather relevant topic. Swimming has a beneficial effect on the child’s body as a whole, strengthening its nervous system and improving sleep, appetite, and adaptive capacity, as well as stimulating metabolism.Aim. To study infant swimming as a progressive direction in improving child health from birth to 3 years old. The objective was to study the importance of infant swimming, consider its main techniques, highlight indications and contraindications, conduct and analyze a survey among parents on this topic. Early start of swimming significantly improves the child’s health, or reduces the current health problems. The skill of independent swimming is not the main goal. The main goal is effective hardening, strengthening immunity and health, correcting identified abnormalities and stimulating proper development.The division of the education period of infants into stages is conditional and depends on the individual characteristics of a child. It is important to observe the basic hardening principles: consistency and graduality.Also, we conducted a survey of parents to study and understand their opinions on teaching swimming. Relevant conclusions were drawn from the results. The relevance of this topic and the need for more active promotion of infant swimming is evidenced by the fact that 69% of parents surveyed consider it necessary to provide home courses on infant swimming. Also, 84% spoke in favor of the need to open specialized centers for teaching swimming for children from birth to 3 years old.
Investigation of The Effects of Diaminopyridine and o-Vanillin Derivative Schiff Base Complexes of Mn(II), Mn(III), Co(II) and Zn(II) Metals on The Oxidative Bleaching Performance of H2O2
Authors: UĞUR Tuğba , TUNA Murat 
Published: June 2021

Catalytic applications are widely used in both industrial and individual applications today due to their many advantages, especially the energy and time they provide. For this purpose, many coordination compounds have been synthesized and their catalytic performances have been investigated in recent years.
In this study, the Schiff base ligand, (N,N’-bis(2-hydroxy-3-methoxyphenylmethylidene)-2,6-pyridinediamine, BHMP), was synthesized with 2,6-diaminopyridine with o-vanillin. Mn(II), Mn(III), Co(II), Zn(II) complexes were obtained with the synthesized ligand. Spectroscopic methods such as FT-IR, 1H-NMR, UV-vis, Mass, and melting point determination methods were used for the structure elucidation of the synthesized compounds. The performances of the obtained complexes as bleach catalysts, which is an important application area of Schiff base complexes, were investigated.
According to the bleaching measurement results; the highest catalytic effect on the bleaching performance of H2O2 in pH 10.5 buffer at 25°C under homogeneous conditions was obtained with Co(II) complex, and it was understood that this complex was followed by Mn(II), Mn(III) and Zn(II) complexes, respectively
NESS2.0: An Updated Version of the Worldwide Dataset for Calibrating and Adjusting Ground-Motion Models in Near Source
Authors: Sgobba Sara , Felicetta Chiara , Lanzano Giovanni , Ramadan Fadel , D’Amico Maria , Pacor Francesca 
Published: June 2021

ABSTRACT
We present an extended and updated version of the worldwide NEar-Source Strong-motion (NESS) flat file, which includes an increased number of moderate-to-strong earthquakes recorded in epicentral area, new source metadata and intensity measures, comprising spectral displacements and fling-step amplitudes retrieved from the extended baseline correction processing of velocity time series. The resulting dataset consists of 81 events with moment magnitude≥5.5 and hypocentral depth shallower than 40 km, corresponding to 1189 three-component waveforms, which are selected to have a maximum source-to-site distance within one fault length. Details on the flat files, metadata, and ground-motion parameters, processing scheme, and statistical findings are presented and discussed. The analysis of these data allows recognizing the presence of distinctive features (such as pulse-like waveforms, large vertical components, and hanging-wall effects) that can be exploited to assess their impact on near-source seismic motion. As an example, we use the NESS2.0 dataset for calibrating an empirical correction factor of a regional ground-motion model (GMM) mainly based on far-field records. In this way, we can adjust the median predictions to account for near-source effects not fully captured by the reference model. The final goal of this work is to promote the use of the NESS2 flat file as a tool to disseminate qualified and referenced near-source data and metadata in the light of improving the constraints of GMMs (both empirical and physics-based) close to the source.
Subsurface Characterization of the Quaternary Active Cheraw Fault in Southeastern Colorado Based on Seismic Imaging
Authors: Zellman Mark S. , Ostenaa Dean A. , Brown Morgan P. 
Published: June 2021

AbstractThe subsurface structure of the late Quaternary active Cheraw fault is relatively unstudied. Vertical displacement estimates of faulted bedrock horizons, characteristics of bedrock structure (e.g., dip), potential association with dissolution of underlying Permian evaporite strata, and whether or not a postulated northeast extension of the topographic scarp is associated with Quaternary faulting have remained open questions. In this study, we assess six 2D seismic reflection profiles that cross the Cheraw fault scarp, demonstrate how Quaternary normal faulting has reactivated pre-existing structures along the northwest flank of the Las Animas arch, and provide new constraints for seismic hazard characterization. We map the fault to depths of at least 1.5–1.8 km into lower Paleozoic strata in which the continuity of the fault through Permian evaporite indicates that dissolution of those stratigraphic intervals has no role in Quaternary surface faulting. Interpretation of the seismic data reveals an ∼75°±5° northwest-dipping fault with ∼24–30  m vertical displacement of upper Cretaceous strata, which coincides with Quaternary scarps at the surface.