bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of new-onset diabetes mellitus and medical therapy for benign prostatic hyperplasia: A population-based study
Authors: Johnstone Jeannette , Lusty Avril , Tohidi Mina , Whitehead Marlo , Tranmer Joan , Nickel J. Curtis , Siemens D. Robert 
Published: August 2021

Introduction: Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms are highly prevalent in the aging male. Similarly, the prevalence of metabolic syndrome is increasing worldwide, with mounting evidence that these two common conditions share more than age as a predisposing factor. The objective of this study was to determine if medical management of BPH is associated with an increased risk of new-onset diabetes mellitus (DM) in routine care.
Methods: This population-based, retrospective cohort study expands on a parent study of linked administrative databases identifying patients diagnosed and treated for BPH between 2005 and 2015. The primary outcome of this secondary analysis was a new diagnosis of DM after the index date of BPH diagnosis. Covariates included age, dyslipidemia, hypertension, and vascular diseases. A Cox proportional hazards regression model was used for inferential statistical analysis.
Results: A total 129 223 men were identified with a BPH diagnosis and no prior history of DM. Of those men, 6390 (5%) were exposed to 5-alpha-reductase inhibitor (5-ARI), 39 592 (31%) exposed to alpha-blocker (AB), and 30 545 (24%) exposed to combination therapy. Compared to those men with no BPH medication use, those exposed to drugs had an increased risk of new DM. Men treated with combination therapy of 5-ARI and AB (hazard ratio [HR] 1.30, 95% confidence interval [CI] 1.25–1.35), 5-ARI monotherapy (HR 1.25, 95% CI 1.17–1.34), or AB monotherapy (HR 1.17, 95% CI 1.13–1.22) all were at higher risk of new DM diagnosis after adjusting for important covariates. When calculating the risk of a new diabetes diagnosis measured from the start of drug exposure, men treated with 5-ARIs had an increased risk of DM compared to AB monotherapy as the reference, with HR 1.12 (95% CI 1.03–1.21) for 5-ARI monotherapy and HR 1.20 (95% CI 1.14–1.25) for combination therapy.
Conclusions: In this large, long-term, retrospective study of men with a BPH diagnosis in routine practice, the risk of a new diagnosis of DM was greater in patients receiving medical management compared to controls. This modest but significant increased risk was highest in men treated with any 5-ARIs, in combination as well as monotherapy, compared to the ABs.
ON QUASI *-BARRELLED SPACES
Authors: GAYAL S. G. 
Published: August 2021

In this paper, a new class of .ocally convex spaces, called quasi *- barrelled spaces is introduced. These spaces are characterized by : A locally convex space $E$ is Quasi *-barrelled if every bornivorous *-barrel in $E$ is a neighbourhood of $O$ in $E$. This class of spaces is a generalization of quasi-barrelled spaces and *-barrelled spaces (K.Anjaneyulu; Gayal : Jour. Math. Phy. Sci. Madras, 1984). Some properties of quasi *-barrelled spaces are sturued. Lastly one example each of
(i) a quasi *-barrelled space which is not quasi-barrelled.
(ii) a quasi *-barrelled space which is not *-barrelled.
is given.
Healthcare Policy for Patients with Chronic Heart Failures at Nam Dinh General Hospital in Vietnam
Authors: Ngoc Pham Thi Bich , Huya Dinh Tran Ngoc , Nhung Pham Thi Hong 
Published: August 2021

The study aims to provide knowledge of healthy food to serve for better health of patients through analyzing the current status of self-care knowledge and practice of patients with chronic heart failure at the Department of Cardiology - Nam Dinh General Hospital in 2018 and evaluate the change in self-care knowledge of patients with chronic heart failure after health education interventions. We perform method of one-group intervention study with before-after comparison. Health education intervention was carried out for 90 patients with chronic heart failure inpatient treatment at Cardiology Department - Nam Dinh General Hospital. Our results show that a good healthcare and nutrition policy for patients are needed: reduce natri, increase fibre-rich foods such as whole grain, vegetables, bean, etc. It pointed that roles of nurses are becoming important because Patients with chronic heart failure have limited knowledge and practice of self-care but have improved significantly after health education interventions. Research results show the need for regular health education to improve knowledge and practice self-care for patients with chronic heart failure. This research finding and recommended healthy foods to support for better health of patients with chronic heart failure in many developing countries.
An Observational Study on Drug Utilization Pattern in Anaemic Pregnant Women in the Tertiary Care Teaching Hospital
Authors: Baile Sunil , Hadia Rajesh , Patel Pankti , Shah Maitree , Soni Priyal , Gaikwad Rita , Rathod Trupal , Joshi Dhaval , Parmar Ghanshyam , Rajput Hemraj Singh 
Published: August 2021

Background: Anemia is a disease that is more prevalent among pregnant women in India.
Objective: To Study the Drug Utilization Pattern, compare and evaluate better drug selection in Anaemic Pregnant Women.
Methodology: A total of 300 pregnant women ranging in the age group of 17 to 38 years and having 1 month to 9 months of pregnancy was included in a study. The medical records of patients were checked and information was recorded. The prescriptions were analyzed for drug utilization patterns. Statistical analysis was done.
Result: Out of all 300 pregnant women 176 patients having iron deficiency Anemia, 99 patients having sickle cell Anemia, 20 patients having folate deficiency Anemia, and the rest of the patients having Vitamin B12 deficiency or hemolytic or beta-thalassemia. The average number of drugs prescribed per patient was 3-4 and the average monthly cost per patient was 920.68 Rs. The most commonly prescribed drug was Vitamin C it is of Category C drug which could be harmful to the fetus followed by MVBC (Multivitamin B complex).
Conclusion: Anemia was commonly seen in 2nd trimester. Sickle cell Anemia was seen in 1/3rd of the patients. Study data highlights that Vitamin C, Calcium & Multivitamin B complex were the most prescribed drugs in anemic patients. Drugs prescribed were produced risk to the fetus according to USFDA criteria.
COVID-19 Pandemic: Public Knowledge, Attitude, and Practice towards Social Distancing and its Impact on the Population and the Healthcare System in Saudi Arabia
Authors: Aljuhni Abdulaziz , Almahmoud Khalid , Alzahrani Sattam , Al-Thakfan Naif , Alswayed Khalid , Kashkary Abdulhameed , Mahmoud Mahmoud 
Published: August 2021

Aims: To determine the knowledge, attitude, and practice of Saudi population towards social distancing and COVID-19.
Study Design: Cross-sectional.
Place and Duration of Study: This cross-sectional study was conducted in Riyadh city, the capital of the Kingdom of Saudi Arabia, during the national lockdown, between July 2020 and December 2020.
Methodology: This cross-sectional study was conducted in Riyadh, Saudi Arabia. A questionnaire composed of a total of 40 questions, which include socio-demographic, knowledge, attitude, and practice questions. According to the responses, a scale has been established in order to categorize the level of knowledge, attitude, and practice towards social distancing and COVID-19 into three categories; good, fair, and poor. One-way analysis of variance (ANOVA) and Independent t-test were used to determine the differences between categories. Multivariable linear regression analysis and Pearson’s correlation were performed in order to identify factors related to KAP.
Results: This study included 407 participants; more than half of them (54%) were females, while (46%) were males. All participants were 18 years and above. The participants showed a fair level of knowledge, a positive attitude, and good practices toward COVID-19.
Conclusion: The findings of this study suggest that Riyadh residents, especially females, have a fair level of knowledge, a positive attitude, and good practices toward COVID-19 and social distancing. More emphasis should be targeted on less educated population and men. This study may help policymakers to identify the target less knowledgeable groups for COVID-19 prevention and health education.
Intra Venous Butorphanol versus Intravenous Nalbuphine for (Intra Operative) Balanced Anaesthesia and Post Operative Analgesic Effect in Patients Undergoing Laparoscopic Surgery
Authors: Irshad B. 
Published: August 2021

Laparoscopic surgery has replaced many of the open surgeries because of its advantages. Both the groups of drugs have hemodynamic stability, analgesia, sedation and decrease the requirement of other anesthetic drugs. So we have chosen Butorphanol and Nalbuphine to study the analgesia and hemodynamic changes in both groups. In our study mean heart rate was lower in Butorphanol group compare to Nalbuphine group. Similarly fifty patients of ASA I&II scheduled for elective laparoscopic surgery, were randomized in to butorphanol group and nalbuphine group. It was observed that there was significant rise in systolic blood pressure & Diastolic Blood pressure after intubation in fentanyl group compare to Butorphanol. This study finds that suppression of sympathetic response to laryngoscopy and intubation was better with Butorphanol than Fentanyl. This study analysis indicates that both Butorphanol and Nalbuphine help in maintaining a steady haemodynamic state all throughout the procedure.
Inverted and Programmable Poynting Effects in Metamaterials
Authors: Ghorbani Aref , Dykstra David , Coulais Corentin , Bonn Daniel , van der Linden Erik , Habibi Mehdi 
Published: August 2021

AbstractThe Poynting effect generically manifests itself as the extension of the material in the direction perpendicular to an applied shear deformation (torsion) and is a material parameter hard to design. Unlike isotropic solids, in designed structures, peculiar couplings between shear and normal deformations can be achieved and exploited for practical applications. Here, a metamaterial is engineered that can be programmed to contract or extend under torsion and undergo nonlinear twist under compression. First, it is shown that the system exhibits a novel type of inverted Poynting effect, where axial compression induces a nonlinear torsion. Then the Poynting modulus of the structure is programmed from initial negative values to zero and positive values via a pre‐compression applied prior to torsion. The work opens avenues for programming nonlinear elastic moduli of materials and tuning the couplings between shear and normal responses by rational design. Obtaining inverted and programmable Poynting effects in metamaterials inspires diverse applications from designing machine materials, soft robots, and actuators to engineering biological tissues, implants, and prosthetic devices functioning under compression and torsion.
‘Lighted’ Assemblies of a PBI Derivative: Activation of Aerial Oxygen via Combined Charge and Energy Transfer Processes for Photocatalytic Oxidative Hydroxylation of Boronic Acids
Authors: Singh Gurpreet , Singh Manpreet , Kumar Sourav , Kumar Manoj , Bhalla Vandana 
Published: August 2021

AbstractThe donor‐acceptor ‘lighted’ assemblies of PBI‐TPY have been developed, which exhibit strong absorption in the visible region, have high photostability, excellent electron transportation ability and high potential to activate aerial oxygen to generate reactive oxygen species, such as singlet oxygen, superoxide anion radical and hydroxide ions. Empowered by excellent photosensitizing properties, assemblies of PBI‐TPY exhibit high photocatalytic efficiency in visible light mediated oxidative hydroxylation of aromatic/aliphatic boronic acids through combined charge/energy transfer processes in the presence of weak electron donor (NEt3) and air as the ‘oxidant’ in mixed aqueous media. The work being presented in this manuscript also reveales the potential of PBI‐TPY assemblies for gram‐scale preparation of phenol and recyclability of upto six catalytic cycles in the oxidative hydroxylation reaction.
Potential Degradation of 4‐Methyltetrahydropyran (4‐MeTHP) under Oxidation Conditions
Authors: Kobayashi Shoji , Tamura Tomoki 
Published: August 2021

Abstract4‐Methyltetrahydropyran (4‐MeTHP) is a next‐generation recyclable ether solvent that can be applied to a wide variety of synthetic reaction methods. Previous studies indicated that 4‐MeTHP could degrade to some extent with certain oxidants, while the oxidation reactions themselves proceeded in good yields. Here we disclose the potential oxidative degradation pathways of 4‐MeTHP when exposed to selected organic‐based and metal‐based oxidants. Crude NMR analyses revealed that degradation of 4‐MeTHP was initiated by C2−H abstraction, giving rise to C2‐ or C4‐oxidized products or the C−C bond cleavage product depending on the oxidants used. This study therefore illustrates possible degradation products of 4‐MeTHP under oxidative conditions, which is particularly helpful in predicting and analyzing trace impurities when adopting 4‐MeTHP or other ethereal solvents in industrial processes.
Thermally stable and superhydrophobic foam prepared by high‐internal phase emulsion for oil/water separation with good recycling capacity
Authors: Deng Shiqin , Zhao Chunxia , Zhu Longbin , Huang Haoran , Li Yuntao , Xiang Dong , Li Hui , Wu Yuanpeng , Huang Shijie 
Published: August 2021

AbstractSuperhydrophobic polymeric foams, with good thermal stability and high‐recycling capacity to remove oil from oily wastewater, are highly desirable for current oily wastewater purification. Herein, poly (styrene‐acrylic acid 2,2,3,4,4,4‐hexafluoro‐butyl ester‐divinylbenzene) foam with porosity as high as 99.27% has been prepared through high‐internal phase emulsions. Therein, poly (cyclotriphosphazene‐co‐4,4′‐sulfonyldiphenol) microspheres, and Span80 act as co‐emulsifier to stabilize the emulsion system. The as‐prepared foams exhibited super hydrophobicity with a water contact angle of 150.3° and thermal stability. Additionally, the oil adsorption capacity of the porous material could reach up to 25.6–53.4 times its mass with accessible and high‐recycling capacity. These aforementioned outstanding properties make our superhydrophobic foam hold potential applications in oil/water separation.
Systematic review and meta‐analysis identify significant relationships between clinical anxiety and lower urinary tract symptoms
Authors: Mahjani Behrang , Koskela Lotta Renström , Batuure Anita , Gustavsson Mahjani Christina , Janecka Magdalena , Hultman Christina M. , Reichenberg Abraham , Buxbaum Joseph D. , Akre Olof , Grice Dorothy E. 
Published: August 2021

AbstractBackgroundLower urinary tract symptoms (LUTS), such as voiding symptoms, overactive bladder, and interstitial cystitis, and anxiety disorders are often comorbid conditions in patients. However, the existing evidence regarding the rates and nature of the co‐occurrence of these conditions has not been systematically evaluated. The aim of this study was to examine these relationships.MethodsWe conducted a systematic review and meta‐analysis to examine the relationship between LUTS and anxiety. We searched for articles published from January 1990 to July 2019 in PubMed, CENTRAL, PsycINFO, and Google Scholar. Outcomes were anxiety‐related disorders and symptoms (clinically significant anxiety) and LUTS. We performed random‐effects meta‐analyses, inspected funnel plots, and applied the Egger's test to evaluate publication bias. We followed PRISMA guidelines and recorded our protocol on PROSPERO (ID = CRD42019118607).ResultsWe identified 814 articles, of which 94 fulfilled inclusion criteria, and 23 had sufficient data for meta‐analysis. The odds ratio (OR) for clinically significant anxiety among individuals with LUTS was 2.87 (95% CI: 2.38,3.46, p < .001). The OR for LUTS among individuals with clinically significant anxiety was 2.87 (95% CI: 1.07,7.74, p < .001), although very few studies examined this relationship. A large value of I2 index suggests high heterogeneity between studies.ConclusionThe results demonstrate a significant association between clinically significant anxiety and LUTS in both females and males. There were limited studies on younger individuals and on individuals ascertained for clinically significant anxiety, which should motivate further study in these areas. Understanding the co‐occurrence of these conditions will lead to better prevention and interventions to ameliorate the progression of the symptoms and improve the quality of life. A thorough assessment of anxiety may provide more optimal care for LUTS patients.
Building bridges: Contextualising a counselling supervision course in Nepal and its potential impact on international practice
Authors: Saunders Jennifer M. 
Published: August 2021

AbstractIn Nepal, supervised counselling practice is relatively new. Supervision training is minimal. The researcher was invited to teach the first master's‐level supervision course in the country. She was aware of how easily Western concepts are unquestioningly taught and accepted. She wanted to learn what was involved in producing a course that was contextually appropriate. Using action research methodology, she employed a dialogical approach to her teaching and learning. A thematic analysis of data from a focus group discussion led to recommendations for policy change in Nepal and implications for international practice. The researcher found that students were disempowered by the inappropriately hierarchical supervision they currently received and also by so much Western study material. The participants recognised a surprising amount of power in the concept of a contextualised supervision course. As well as giving them worth and identity, the students believed it could enable them to uphold ethical counselling standards in the absence of a professional body in Nepal. Cultural strengths and challenges in the context of counselling supervision were also identified. Although the contextualisation process was more complex than expected, it also produced more sense of ownership. Some of the students wanted to continue to develop and help teach the course in the future. Data from the reflective research journal and further discussion identified key issues for the process of contextualisation of supervision practice and teaching. They describe one way of ‘building bridges’.
A qualitative study of university students' experience of Internet‐based CBT for depression
Authors: Gericke Franco , Ebert David D. , Breet Elsie , Auerbach Randy P. , Bantjes Jason 
Published: August 2021

AbstractInternet‐based treatments for depression have the potential to promote the mental health of university students. Yet, little is known about students' experiences of Internet‐based mental health interventions (also known as e‐interventions) and the acceptability of this mode of treatment in low‐resource settings. Our aims were to investigate South African university students' experiences of using a brief semi‐guided Internet‐based cognitive behavioural therapy (iCBT) for depression and document the acceptability of this mode of psychotherapy. Data were collected via in‐depth semi‐structured interviews with students (n = 9) who had moderate to moderately severe symptoms of depression (as assessed by the PHQ‐9) and had used a 7 session guided skills‐based iCBT intervention. Data were analysed inductively using thematic analysis, with the aid of Atlas‐ti software. Participants found the anonymity, privacy and accessibility of iCBT appealing, believing this facilitated use of the intervention and overcame stigma associated with accessing traditional campus counselling services. The intervention was helpful and facilitated self‐disclosure, emotional expression, self‐awareness and skill acquisition. However, students also reported disappointment with the lack of human contact and immediate responsiveness, articulating an expectation that the e‐intervention would mimic face‐to‐face psychotherapy. Moves to incorporate iCBT into student counselling should take account of and manage students' expectations about the ability of e‐interventions to mimic traditional therapy and/or incorporate more opportunities for human interaction.
Rosette‐forming glioneuronal tumor of the fourth ventricle; A case report and review of the literature
Authors: Verbančič Tadeja , Ravnik Janez , Kavalar Rajko 
Published: August 2021

AbstractDespite mostly indolent course and favorable postoperative outcome long‐term follow‐up studies are needed to identify the most appropriate therapeutic strategies to minimize surgical morbidity and neurologic injury in patients with RGNT.
Deuterated Indocyanine Green (ICG) with Extended Aqueous Storage Shelf‐Life: Chemical and Clinical Implications
Authors: Li Dong‐Hao , Smith Bradley D. 
Published: August 2021

AbstractIndocyanine Green (ICG) is a clinically approved near‐infrared fluorescent dye that is used extensively for various imaging and diagnostic procedures. One drawback withICGis its instability in water, which means that reconstituted clinical doses have to be used very shortly after preparation. Two deuterated versions ofICGwere prepared with deuterium atoms on the heptamethine chain, and the spectral, physiochemical, and photostability properties were quantified. A notable mechanistic finding is that self‐aggregation ofICGin water strongly favors dye degradation by a photochemical oxidative dimerization reaction that gives a nonfluorescent product. Storage stability studies showed that replacement of C−H with C−D decreased the dimerization rate constant by a factor of 3.1, and it is likely that many medical and preclinical procedures will benefit from the longer shelf‐lives of these two deuteratedICGdyes. The discovery thatICGself‐aggregation promotes photoinduced electron transfer can be exploited as a new paradigm for next‐generation photodynamic therapies.
Stable Noble Gas Compounds Based on Superelectrophilic Anions [B12(BO)11]− and [B12(OBO)11]−
Authors: Xu Jianzhi , Li Mengyang , Xu Song , Pei Gerui , Zhao Xintian , Kong Chuncai , Yang Zhimao , Yang Tao , Hou Gao‐Lei 
Published: August 2021

AbstractSuperelectrophilic monoanions [B12(BO)11]− and [B12(OBO)11]−, generated from stable dianions [B12(BO)12]2− and [B12(OBO)12]2−, show great potential for binding with noble gases (Ngs). The binding energies, quantum theory of atoms in molecules (QTAIM), natural population analysis (NPA), energy decomposition analysis (EDA), and electron localization function (ELF) were carried out to understand the B−Ng bond in [B12(BO)11Ng]− and [B12(OBO)11Ng]−. The calculated results reveal that heavier noble gases (Ar, Kr, and Xe) bind covalently with both [B12(BO)11]− and [B12(OBO)11]− with large binding energies, making them potentially feasible to be synthesized. Only [B12(OBO)11]− could form a covalent bond with helium or neon but the small binding energy of [B12(OBO)11He]− may pose a challenge for its experimental detection.