bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Laser Surfacing on the Microstructure and Mechanical Properties of Ultrasonic Welded NiTi Joints
Authors: Ao S. S. , Li C. J. , Zhang W. , Oliveira J. P. , Zeng Z. , Luo Z. 
Published: June 2021

Abstract
In the present work, the effects of laser surfacing aiming at modifying the surface roughness on NiTi sheets prior to the application of ultrasonic welding (USW) were investigated. Three different configurations joining original and laser surfaced specimens were performed: original/original (referred as O/O), original/treated (referred as O/T), and treated/treated (referred as T/T). The influence of surface roughness on the interface formation, diffusion, and mechanical properties was investigated. It is observed that when both bonding surfaces becomes rougher (T/T configuration), the joint strength is the highest, followed by both smooth bonding surfaces (O/O configuration), and the strength of the joint is the lowest when only one of the bonding surfaces was roughened (O/T configuration), which is related to the degree of plastic deformation at the joining interface. The main joining mechanism of NiTi to the Al interlayer was a metallic bonding caused by shear plastic deformation and formation and growth of micro welds at the joining interfaces. Laser surfacing facilitates the metallic bonding, which is directly reflected in the change of the thickness of the Al interlayer after USW. This also helps to produce a mechanical interlocking at the interface, although there is no significant difference in the elemental diffusion. Interfacial failure occurred in all joints tested under different surface contact conditions and exhibited ductile-like fracture characteristics.
A Data-Driven Framework for Buckling Analysis of Near-Spherical Composite Shells Under External Pressure
Authors: Doshi Mitansh , Ning Xin 
Published: June 2021

Abstract
This paper presents a data-driven framework that can accurately predict the buckling loads of composite near-spherical shells (i.e., variants of regular icosahedral shells) under external pressure. This framework utilizes finite element simulations to generate data to train a machine learning regression model based on the open-source algorithm Extreme Gradient Boosting (XGBoost). The trained XGBoost machine learning model can then predict buckling loads of near-spherical shells with a small margin of error without time-consuming finite element simulations. Examples of near-spherical composite shells with various geometries and material layups demonstrate the efficiency and accuracy of the framework. The machine learning model removes the demanding hardware and software requirements on computing buckling loads of near-spherical shells, making it particularly suitable to users without access to those computational resources.
Running Biomechanics of Adolescents With Autism Spectrum Disorder
Authors: Bennett Hunter J. , Haegele Justin A. 
Published: June 2021

Abstract
Research examining gait biomechanics of persons with autism spectrum disorder (ASD) has grown significantly in recent years and has demonstrated that persons with ASD walk at slower self-selected speeds and with shorter strides, wider step widths, and reduced lower extremity range of motion and moments compared to neurotypical controls. In contrast to walking, running has yet to be examined in persons with ASD. The purpose of this study was to examine lower extremity running biomechanics in adolescents (13–18-year-olds) with ASD and matched (age, sex, and body mass index (BMI)) neurotypical controls. Three-dimensional kinematics and ground reaction forces (GRFs) were recorded while participants ran at two matched speeds: self-selected speed of adolescents with ASD and at 3.0 m/s. Sagittal and frontal plane lower extremity biomechanics and vertical GRF waveforms were compared using two-way analyses of variances (ANOVAs) via statistical parametric mapping (SPM). Adolescents with ASD ran with reduced stride length at self-selected speed (0.29 m) and reduced vertical displacement (2.1 cm), loading-propulsion GRFs (by 14.5%), propulsion plantarflexion moments (18.5%), loading-propulsion hip abduction moments (44.4%), and loading knee abduction moments (69.4%) at both speeds. Running at 3.0 m/s increased sagittal plane hip and knee moments surrounding initial contact (both 10.4%) and frontal plane knee angles during midstance (2.9 deg) and propulsion (2.8 deg) compared to self-selected speeds. Reduced contributions from primarily the ankle plantarflexion but also knee abduction and hip abduction moments likely reduced the vertical GRF and displacement. As differences favored reduced loading, youth with ASD can safely be encouraged to engage in running as a physical activity.
A Computational Study of the Thermodynamic Conditions Leading to Autoignition in Nanosecond Pulsed Discharges
Authors: Gururajan Vyaas , Scarcelli Riccardo , Karpatne Anand , Breden Douglas , Raja Laxminarayan , Biswas Sayan , Ekoto Isaac 
Published: June 2021

Abstract
Nanosecond pulsed discharges have attracted the attention of engine manufacturers due to the possibility of attaining distributed ignition sites that accelerate burn rates while resulting in very little electrode erosion. Multidimensional modeling tools currently capture the electrical structure of such discharges accurately, but resolving the chemical structure remains a challenging problem owing to the disparity of time-scales in streamer propagation (nanoseconds) and ignition phenomena (microseconds). The purpose of this study is to extend multidimensional results toward resolving the chemical structure in the wake of streamers (or the afterglow) by using a batch reactor model (BRM). This can afford the use of very detailed chemical kinetic information. The full nonequilibrium nature of the electrons is taken into account, along with fast gas heating, shock wave propagation, and thermal diffusion. The results shed light on ignition phenomena brought about by such discharges.
Design and Kinematics of a Novel Double-Ring Truss Deployable Antenna Mechanism
Authors: Cao Wen-ao , Xi Sheng , Ding Huafeng , Chen Ziming 
Published: June 2021

Abstract
This paper aims to present the topological structure design and kinematic analysis of a novel double-ring truss deployable satellite antenna mechanism. First, a new topological scheme and a new rectangular prism deployable linkage unit are proposed for constructing the kind of antenna mechanisms. Second, the degree-of-freedom (DOF) of the deployable unit and the antenna mechanism are analyzed based on structure decomposition and screw theory. Third, the kinematic model of the double-ring truss deployable antenna mechanism is established based on its structural characteristics. Finally, a typical numerical example is used to illustrate the effectiveness of the designed mechanism and the established kinematic model. The new double-ring truss deployable antenna mechanism consists of the units with the better structural symmetry and has simpler joint axis layouts, comparing with the same type of most existing mechanisms.
Computer Simulation of Heat Transfer in Alumina and Cement Rotary Kilns
Authors: Singh Atinder Pal , Ghoshdastidar P. S. 
Published: June 2021

Abstract
This paper presents computer simulation of heat transfer in alumina and cement rotary kilns. The model incorporates radiation exchange among solids, wall, and gas, convective heat transfer from the gas to the wall and the solids, contact heat transfer between the covered wall and solids, and heat loss to the surrounding as well as chemical reactions. The mass and energy balances of gas and solids have been performed in each axial segment of the kilns. The energy equation for the wall is solved numerically by the finite-difference method. The dust entrainment in the gas is also accounted for. The solution marches from the solids inlet to the solids outlet. The kiln length predicted by the present model of the alumina kiln is 77.5 m as compared to 80 m of the actual kiln of Manitius et al. (1974, “Mathematical Model of an Aluminum Oxide Rotary Kiln,” Ind. Eng. Chem. Process Des. Dev., 13(2), pp. 132–142). In the second part, heat transfer in a dry process cement rotary kiln is modeled. The melting of the solids and coating formation on the inner wall of the kiln are also taken into account. A detailed parametric study lent a good physical insight into axial solids and gas temperature distributions, and axial variation of chemical composition of the products in both the kilns.
Monitoring of Palliative Care Symptoms and Concerns in Specialized Palliative Home Care Using an Electronic Version of the Integrated Palliative care Outcome Scale (Palli-MONITOR): protocol for a mixed-methods study
Authors: Bolzani Anna , Ramsenthaler Christina , Hodiamont Farina , Burner-Fritsch Isabel Sophie , Bausewein Claudia 
Published: June 2021

IntroductionOver the last decades, patient-reported outcome (PRO) measures have been developed to better understand the patient’s perspective and enable patient-centred care. In palliative care, the Integrated Palliative care Outcome Scale (IPOS) is recommended as a PRO tool. Its implementation in specialised palliative home care (SPHC) would benefit from an electronic version validated for the setting.Following the Medical Research Council (MRC) guidance, the study Palli-MONITOR is developing (phase 1) and testing the feasibility (phase 2) of implementing the electronic version of IPOS (eIPOS) in the SPHC setting to inform a cluster-randomised phase 3 trial.Methods and analysisPalli-MONITOR is a multicentre, sequential mixed-methods, two-phase development and feasibility study. The study consists of four substudies. In phase 1 (MRC development phase), qualitative patient interviews and focus groups with SPHC professionals are used to identify barriers and facilitators of eIPOS (substudy I). Substudy II tests the equivalence of eIPOS and IPOS in a crossover randomised controlled trial. Phase 2 (MRC feasibility/piloting phase) includes a quasi-experimental study with two control groups (substudy III), and qualitative interviews as well as focus groups to explore the feasibility and acceptability of the developed intervention (substudy IV).Qualitative data will be analysed with thematic analysis following the framework approach. Quantitative analysis uses a two-way intraclass correlation coefficients model for the equivalence testing. Quantitative analysis of the quasi-experimental study will focus on the primary outcomes, recruitment rates and completeness of eIPOS. Secondary outcomes will include intraindividual change in palliative symptoms and concerns, quality of life and symptom burden.Ethics and disseminationApproval of the ethics committee of the Ludwig Maximilian University Munich was received for all study parts. Results and experiences will be presented at congresses and in written form. Additionally, participating SPHC teams will receive summarised results.Trial registration numberNCT03879668.
Association between end-of-life cancer care and immigrant status: a retrospective cohort study in Ontario, Canada
Authors: Chu Anna , Barbera Lisa , Sutradhar Rinku , Oz Urun Erbas , O'Leary Erin , Seow Hsien 
Published: June 2021

ObjectiveTo compare recent immigrants and long-term residents in Ontario, Canada, on established health service quality indicators of end-of-life cancer care.DesignRetrospective, population-based cohort study of cancer decedents between 2004 and 2015.SettingOntario, Canada.ParticipantsWe grouped 13 085 immigrants who arrived in Ontario in 1985 or later into eight major ethnic groups based on birth country, mother tongue and surname, and compared them to 229 471 long-term residents who were ≥18 years at the time of death.Primary and secondary outcome measuresAggressive care, defined as a composite of ≥2 emergency department visits, ≥2 new hospitalisations or an intensive care unit admission within 30 days of death; and supportive care, defined as a physician house call within 2 weeks, or palliative nursing or personal support worker home visit within 6 months of death. Multivariable logistic regression was used to examine the association between immigration status and the odds of each main outcome.ResultsCompared with long-term residents, immigrants overall and by ethnic group had higher rates of aggressive care (13.7% vs 17.5%, respectively; p<0.001). Among immigrants, Southeast Asians had the highest use while White-Eastern and Western Europeans had the lowest. Supportive care use was similar between long-term residents and immigrants (50.0% vs 50.5%, respectively; p=0.36), though lower among Southeast Asians (46.6%) and higher among White-Western Europeans (55.6%). After adjusting for sociodemographic characteristics and comorbidities, immigrants remained more likely than long-term residents to receive aggressive care (OR: 1.15, 95% CI 1.09 to 1.21), yet were less likely to receive supportive care (OR: 0.95, 95% CI 0.91 to 0.98).ConclusionsAmong cancer decedents in Ontario, immigrants are more likely to use aggressive healthcare services at the end of life than long-term residents, while supportive care varies by ethnicity. Contributors to variation in end-of-life care require further study.
Daily intake of yogurt drink fortified either with vitamin D alone or in combination with added calcium causes a thyroid-independent increase of resting metabolic rate in adults with type 2 diabetes: a randomized, double-blind, clinical trial
Authors: Nikooyeh Bahareh , Shariatzadeh Nastaran , Rismanchi Marjan , Hollis Bruce W. , Neyestani Tirang R. 
Published: June 2021

We investigated the effect of daily intake of yogurt drink fortified with either vitamin D alone or with added calcium on resting metabolic rate (RMR), thyroid hormones and homeostatic model assessment for insulin resistance in subjects with type 2 diabetes (T2D). A total of 75 adult subjects with T2D were randomly assigned to 1 of the 3 groups to receive either D-fortified yogurt drink (DY; 1000 IU vitamin D/day), Ca-D-fortified yogurt drink (CDY; 1000 IU vitamin D plus 500 mg calcium), or plain yogurt drink for 12 weeks. All assessments were done at the baseline and after the intervention. The concentrations of anti-thyroid peroxidase antibody (anti-TPO-Ab), intact parathyroid hormone (iPTH) and thyroid stimulating hormone (TSH) had declined significantly compared with baseline values only in the CDY group. The mean RMR increased in both DY and CDY groups (p < 0.001 for both). Also, changes of serum concentrations of 25-hydroxycalciferol (B = 2.96, 95% confidence interval (CI) = 1.3 to 4.6, p = 0.001) and iPTH (B = –2.41, 95% CI = –4.5 to –0.31, p = 0.025) remained significant predictors of RMR changes even after adjustment for changes of serum concentrations of TSH (B = –18.2, 95% CI = –61.7 to 25.2, p = 0.406). Daily intake of vitamin D together with calcium at physiological doses has attenuating effect on anti-TPO-Ab and TSH. Also, vitamin D with or without added calcium causes a significant thyroid-independent increase in RMR in euthyroid subjects with T2D. Registered at clinicaltrials.gov as NCT01229891. Novelty: Daily intake of vitamin D with calcium at physiological doses has attenuating effect on anti-TPO-Ab and TSH. Vitamin D with or without added calcium causes a thyroid-independent increase in RMR in euthyroid subjects with T2D.
Inhibiting the Inhibitors of Apoptosis: When Two Targets Are Better Than One
Authors: Larkin Karilyn T.M. , Byrd John C. 
Published: June 2021

Abstract

Summary:
In this issue of Cancer Discovery, Pullarkat and colleagues present the results from a phase I clinical trial that is the first to combine small-molecule inhibitors for multiple antiapoptotic proteins, BCL2 as well as BCL-XL, with a traditional chemotherapy backbone for patients with relapsed/refractory acute lymphoblastic leukemia. This trial has demonstrated impressive response rates with acceptable toxicity while providing proof of concept that dual targeting—hitting BCL2 hard and BCL-XL soft—is both effective and tolerable in a heterogeneous patient population with prior existing cytopenias.
See related article by Pullarkat et al., p. 1440.
Revealing ARID1A Function in Gastric Cancer from the Bottom Up
Authors: Zafra Maria Paz , Dow Lukas E. 
Published: June 2021

Abstract

Summary:
In this issue of Cancer Discovery, Lo and colleagues use CRISPR-based genome engineering in primary human gastric organoids to reveal the functional consequences of ARID1A loss in the early stages of gastric cancer. They show that ARID1A disruption is not tolerated in wild-type organoids, but in the context of TP53 loss, leads to WNT suppression, mucinous metaplasia, enhanced tumorigenicity, and selectively toxicity to BIRC5/Survivin inhibition.
See related article by Lo et al., p. 1562.
Dialysis Mode and Associated Outcomes in Patients With End‐Stage Renal Disease and Atrial Fibrillation: A 14‐Year Nationwide Cohort Study
Authors: Chang Chih‐Hsiang , Fan Pei‐Chun , Lin Yu‐Sheng , Chen Shao‐Wei , Wu Michael , Lin Ming‐Shyan , Lu Cheng‐Hui , Chang Po‐Cheng , Hsieh Ming‐Jer , Wang Chao‐Yung , Wang Chun‐Li , Chu Pao‐Hsien , Wu Victor Chien‐Chia 
Published: June 2021

Background
Benefits of patients with end‐stage renal disease and atrial fibrillation undergoing peritoneal dialysis (PD) or hemodialysis are unknown.

Methods and Results
Patients undergoing dialysis were retrieved from Taiwan National Health Insurance Research Database during 2001 to 2013 and separated into PD or hemodialysis. Primary outcomes were ischemic stroke/systemic embolism, major bleeding, and intracranial hemorrhage (ICH). An inverse probability of treatment weighting based on propensity score was used to reduce the confounding. The risk of outcomes between PD and hemodialysis was compared using Cox proportional hazard model for fatal outcomes or Fine and Gray subdistribution hazard model which considered death a competing risk, respectively. A total of 7916 patients with end‐stage renal disease with atrial fibrillation undergoing PD or hemodialysis during 2001 to 2013 were identified. After exclusion criteria, 363 patients receiving PD and 5302 patients receiving hemodialysis were analyzed. At 1‐year follow‐up, the risk of ICH was significantly lower in the PD group compared with the hemodialysis group (0.2% versus 0.9%; subdistribution hazard ratio [SHR], 0.31; 95% CI, 0.17–0.57). At 3‐year follow‐up, the risks of major bleeding and ICH were significantly lower in the PD group compared with the hemodialysis group (major bleeding: 1.8% versus 3.2%; SHR, 0.68; 95% CI, 0.53–0.87; ICH: 0.5% versus 2%; SHR, 0.32; 95% CI, 0.21–0.48). At 5‐year follow‐up, ischemic stroke/systemic embolism, major bleeding, and ICH were significantly lower in the PD group compared with the hemodialysis group (ischemic stroke/systemic embolism: 12.4% versus 17.7%, SHR, 0.87; 95% CI, 0.79–0.96; major bleeding: 2.6% versus 4.1%; SHR, 0.79; 95% CI, 0.64–0.97; ICH: 0.5% versus 2.6%; SHR, 0.25; 95% CI, 0.17–0.37).

Conclusions
In patients with end‐stage renal disease and atrial fibrillation, dialytic modalities by PD or hemodialysis impacted these patients differently. There were overall reduced ischemic stroke/systemic embolism, major bleeding, and ICH at 5‐year follow‐up in patients undergoing PD compared with hemodialysis.
Professor James Leslie Brierly and His First Chinese Pupil Li Shengwu at Oxford University Faculty of Law (1927–1930)
Authors: Li Chen 
Published: June 2021

AbstractThis article focuses on James Brierly’s acceptance and supervision of Li Shengwu—the first Chinese student to conduct research into international law at Oxford. In Section 2, it traces Li Shengwu’s admission by Oxford. Section 3 outlines Li’s draft thesis and explains possible reasons for his failure to graduate.
The Fast Response of the Atmospheric Water Cycle to Anthropogenic Black Carbon Aerosols during Summer in East Asia
Authors: Pan Chen , Zhu Bin , Fang Chenwei , Kang Hanqing , Kang Zhiming , Chen Hao , Liu Duanyang , Hou Xuewei 
Published: June 2021

AbstractStudies of the climate effects of black carbon (BC) in East Asia are not abundant and the effects remain uncertain. Using the Community Earth System Model version 1 (CESM1) with Peking University’s emissions data, the fast response of the atmospheric water cycle to anthropogenic BC during summer in East Asia is investigated in this study. Results show that the CESM1-simulated BC concentration and its direct effective radiative forcing are comparable to observations. With the combination of aerosol–radiation interaction (ARI) and non-aerosol–radiation interaction (including aerosol–cloud interaction and surface albedo effects), anthropogenic BC induces a “wetter south and drier north” pattern over East Asia during summer. Also, anthropogenic BC affects the summer precipitation primarily through changing moisture transport rather than altering local evaporation over East Asia. Using the self-developed atmospheric water tracer method, the responses of dominant moisture sources [the tropical Indian Ocean (TIO) and northwest Pacific] to anthropogenic BC are investigated. Results show that the moisture originating from southwest monsoon-related sources (especially the TIO) is more responsive to anthropogenic BC effects over East Asia. In particular, differing from total precipitation, TIO-supplied precipitation shows a significant response to the ARI of anthropogenic BC over East Asia. Process analyses show that anthropogenic BC affects the southwest monsoon-related moisture supplies primarily via advection, deep convection, and cloud macrophysics. Interestingly, the anthropogenic BC-induced changes of TIO-supplied water vapor in these three processes are all dominated by the ARI over East Asia.
Thyroidectomy for Graves’ Disease Predicts Postoperative Neck Hematoma and Hypocalcemia: A North American cohort study
Authors: Mohtashami Sadaf , Richardson Keith , Forest Veronique-Isabelle , Mlynarek Alex , Payne Richard J. , Tamilia Michael , Pusztaszeri Marc P. , Hier Michael P. , Sadeghi Nader , Mascarella Marco A. 
Published: June 2021

Objective: Examine the association of Graves’ disease with the development of postoperative neck hematoma. Design: A cohort of patients participating in the Thyroid Procedure-Targeted Database of the National Surgical Quality Improvement Program from January 1, 2016 to December 31, 2018. Setting: A North American surgical cohort study. Methods: 17 906 patients who underwent thyroidectomy were included. Propensity score matching was performed to adjust for differences in baseline covariates. Multivariate logistic regression was used to ascertain the association between thyroidectomy for Graves’ disease and risk of postoperative adverse events within 30 days of surgery. The primary outcome was postoperative hematoma. Secondary outcomes were postoperative hypocalcemia and recurrent laryngeal nerve injury. Results: One-to-three propensity score matching yielded 1207 patients with mean age (SD) of 42.6 (14.9) years and 1017 (84.3%) female in the group with Graves’ disease and 3621 patients with mean age (SD) of 46.7 (15.0%) years and 2998 (82.8%) female in the group with indications other than Graves’ disease for thyroidectomy. The cumulative 30-day incidence of postoperative hematoma was 3.1% (38/1207) in the Graves’ disease group and 1.9% (70/3621) in other patients. The matched cohort showed that Graves’ disease was associated with higher odds of postoperative hematoma (OR 1.65, 95% CI 1.10-2.46) and hypocalcemia (OR 2.04, 95% CI 1.66-2.50) compared with other indications for thyroid surgery. There was no difference in recurrent laryngeal nerve injury among the 2 groups. Conclusions: Patients with Graves’ disease undergoing thyroidectomy are more likely to suffer from postoperative hematoma and hypocalcemia compared to patients undergoing surgery for other indications.