bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Dirofilaria immitis in mosquitoes (Diptera) – systematic review and meta-analysis
Authors: Riahi Seyed Mohammad , Yusuf Mustapha Ahmed , Azari-Hamidian Shahyad , Solgi Rahmat 
Published: February 2021

Abstract
Knowledge of the vectors of dirofilariasis in the world beside the treatment of infected dog is crucial to establish mosquito vector-based control programs. The current systematic review and meta-analysis were conducted on published studies, documenting the prevalence of Dirofilaria immitis infected/infective mosquitoes from field surveys and laboratory experiments under controlled conditions. Articles up through 2019 from Scopus, PubMed, Embase, Web of Science, Google Scholar were screened systematically. The overall prevalence of D. immitis infected/infective mosquitoes was estimated using a random effect model. Meta-regression was used to identify factors related to high dirofilariasis prevalence in the vectors. In these studies, the detection method was not identified as a heterogeneity and the overall prevalence in both subgroups had overlap (7.9-34.9 and 1.5-48.5). The overall prevalence of infective stage was 2.6 (95% CI: 0.97-4.77 per 1,000) and 84.7 per 1000 (95% CI: 20.5-183.8 per 1,000) for the field survey/laboratory experiment, respectively. The higher overall prevalence of D. immitis infected/infective mosquitoes were reported across studies in which take place in Eastern Mediterranean Region office (EMRO), longitude: 80 to 110, latitude: 20 to 40, annual rainfall: 250 to 1000, sea level: 26 to 100 and <1,000, humidity: 66 to 70, during 2000 to 2005 by dissection methods. Our review determined that mosquito species within the genus Anopheles and to a less extent Culex were the main vectors of dirofilariasis.
Creating a system of indicators for analyzing the external and internal environment of the company
Authors: Ганченко Д.Н. , Нестеренко Е.С. 
Published: February 2021

В статье авторами систематизированы последствия инфляции в две отдельные группы: экономические и социальные последствия. Проведен анализ последствий инфляционных процессов. Выделены направления перераспределения доходов в обществе, которое вызвано инфляционными процессами. Авторами обозначены три основных способа финансирования бюджетного дефицита. Анализируя последствия инфляции, также отдельно рассмотрены издержки со стороны фирм – издержки «меню», а со стороны потребителей – эффект «стоптанных башмаков».
In the article, the authors systematize the consequences of inflation into two separate groups: economic and social consequences. The analysis of the consequences of inflationary processes is carried out. The directions of income redistribution in society, which is caused by inflationary processes, are highlighted. The authors identify three main ways to Finance the budget deficit. Analyzing the effects of inflation are also considered separately the costs of firm – costs «menu», and from consumers – the effect of «worn out boots».
Quantitative analysis of causal relationships between indicators of informal employment and indicators characterizing the socio-economic development of the regions of the Russian Federation
Authors: Дубравская Э.И. 
Published: February 2021

Для принятия управленческих решений по регулированию рынка труда на региональном уровне необходима объективная статистическая оценка взаимосвязи неформальной занятости с показателями социально-экономического развития. В статье дана количественная оценка данной взаимосвязи с применением критерия Грейнджера.
Managerial decisions on the regulation of the labor market at the regional level should be based on an objective statistical assessment of the relationship of informal employment with indicators of socio-economic development is required. The article provides a quantitative assessment of this relationship using the Grager criterion.
Practical aspects of management analysis of assortment and pricing policy
Authors: Шкилева С.С. , Орлова Е.А. 
Published: February 2021

Существующий сегодня метод проведения управленческого анализа ассортиментной и ценовой политики построен исключительно на теоретических положениях, требующих практической реализации с целью оптимизации деятельности организации. В статье рассмотрена проблема проведения управленческого анализа ассортиментной и ценовой политики на примере компании «Градиент». При проведении управленческого анализа эффективно использовался комплекс существующих фундаментальных методов исследования, в т.ч. анализ расчета потенциала организации, числовые (формальные) методы. Также обосновано применение нескольких подходов при реализации данной методики, в число которых входит составление функции и использование современных программных обеспечений как западного, так и отечественного происхождения. В результате определено, что наиболее эффективным инструментом проведения анализа ассортиментной и ценовой политики является автоматизация управленческого учета и анализа посредством специальных программ.
The current method of conducting management analysis of assortment and pricing policy is based solely on theoretical provisions that require practical implementation in order to optimize the organization's activities. The article deals with the problem of conducting a management analysis of assortment and price policy on the example of the company «Gradien». When conducting management analysis, a set of existing fundamental research methods was effectively used, including analysis of calculating the organization's potential, numerical (formal) methods. It is also justified to apply several approaches to the implementation of this methodology, including the compilation of functions and the use of modern software of both Western and domestic origin. As a result, it was determined that the most effective tool for analyzing the assortment and price policy is the automation of management accounting and analysis through special programs.
Functions and forms of interaction between the state and entrepreneurship
Authors: Андреев В.В. 
Published: February 2021

Исследованы функции и формы взаимодействия государства и предпринимательства. Определена особая роль государства в обеспечении экономической свободы предпринимательства посредством формирования экономического механизма. Проведен комплексный анализ форм взаимодействия общественных организаций предпринимателей и органов исполнительной власти с выявлением преимуществ и недостатков рассмотренных форм и механизмов взаимодействия. Рекомендована современная методика оценки эффективности взаимодействия структур бизнеса и органов исполнительной власти, позволяющая получать обоснованные экспертные оценки в разрезе предварительно выработанных критериев, комплексно формировать информационное сопровождение процесса разработки эффективных стратегий развития современного бизнеса и обеспечения его взаимодействия с государственными структурами.
The functions and forms of interaction between the state and entrepreneurship are studied. The special role of the state in ensuring economic freedom of entrepreneurship through the formation of an economic mechanism is defined. A comprehensive analysis of the forms of interaction between public organizations of entrepreneurs and Executive authorities was carried out, identifying the advantages and disadvantages of the considered forms and mechanisms of interaction. We recommend a modern methodology for evaluating the effectiveness of interaction between business structures and Executive authorities, which allows us to obtain sound expert assessments in the context of pre-developed criteria, and comprehensively form information support for the process of developing effective strategies for the development of modern business and ensuring its interaction with government agencies.
Development of the life cycle of the organization: aspects of management
Authors: Макаревич Е.В. , Игнатова Л.Н. 
Published: February 2021

Рассмотрены подходы к управлению жизненным циклом организации, обоснована возможность применения инструментов организационного развития. Приведена систематизация особенностей каждого из этапов развития организации. В частности, для стадии формирования организации важно определение видов и целей деятельности путем выяснения представлений о потребностях потенциального клиента. Уровень роста и зрелости организации отличается ориентацией на расширение круга потребителей, а также формирование собственного имиджа. Проблемы, возникающие перед организацией, достигшей зрелости, носят преимущественно внутренний характер. Этап спада – самый сложный и решающий этап существования организации. Если организации удается преодолеть кризисные явления, она может пройти несколько циклов своего развития.
possibility of using organizational development tools is substantiated. The systematization of the features of each of the stages of development of the organization is given. In particular, for the stage of forming an organization, it is important to determine the types and goals of activities by clarifying ideas about the needs of a potential client. The level of growth and maturity of the organization is characterized by an orientation towards expanding the circle of consumers, as well as the formation of its own image. The problems facing an organization that has reached maturity are predominantly internal in nature. The recession phase is the most difficult and decisive stage in an organization's existence. If the organization manages to overcome the crisis phenomena, it can go through several cycles of its development
Institutional environment for the development of the regional economy
Authors: Остапенко Е.А. 
Published: February 2021

Экономический рост и устойчивое развитие социально-экономической системы региона обеспечивает институциональная поддержка. Именно институтам отводится основная роль в обеспечении конкурентоспособности. Равным образом, конкурентоспособность обуславливается уровнем развития инфраструктуры, рыночных, финансовых и иных рычагов взаимодействия. В науке совокупность указанных факторов определяется как институциональная инфраструктура. В этой связи актуализируется разработка теоретических и методологических основ формирования институциональной инфраструктуры.
Institutional support provides economic growth and sustainable development the socio-economic system the region. It is institutions that are assigned the main role in ensuring competitiveness. Equally, competitiveness is determined by the level of infrastructure development, market, financial and other levers of interaction. In science, the combination of these factors is defined as the institutional infrastructure. In this regard, the development theoretical and methodological foundations the formation institutional infrastructure is being updated.
Health as the basis for the formation of human capital in the modern world
Authors: Тугускина Г.Н. , Тактарова С.В. 
Published: February 2021

В статье рассматривается формирование здоровья, как основной компоненты человеческого капитала. Приводится анализ состояния системы здравоохранения в России. Обозначены проблемы, влияющие на рост смертности и естественной убыли населения. Сделан вывод о влиянии принимаемых на государственном уровне решений на продолжительность жизни россиян.
The article discusses the formation of health as the main component of human capital. The analysis of the state of the healthcare system in Russia is given. The problems affecting the growth of mortality and natural population decline are identified. The conclusion is made about the influence of decisions made at the state level on the life expectancy of Russians.
Relationship and features of functioning of agricultural production and agricultural engineering at the regional level in the conditions of the covid-19 pandemic
Authors: Федотов А.В. , Пилюгин А.Ю. 
Published: February 2021

В статье рассматриваются проблемы развития рынка сельскохозяйственной продукции и сельскохозяйственной техники в условиях экономического кризиса вызванного пандемии covid-19. Рынок характеризуется, как со стороны спроса, так и предложения. Глобальное закрытие границ и приостановка бизнеса по многим направлениям, вносит значительные изменения в устоявшиеся движения товарных ресурсов. Производится необходимый анализ мер влияния данных проблем на отрасль сельского хозяйства, проводится оценка перспектив и возможностей выхода из затруднительных внешних условий. Рассматриваются меры поддержки Российских производителей сельскохозяйственной техники.
The article examines the development of the market for agricultural products and agricultural machinery in the economic crisis caused by the covid-19 pandemic. The market is characterized by both supply and demand. Global border closures and business suspensions in many areas are making significant changes to established movements of commodity resources. The necessary analysis of the measures of impact of these problems on the agricultural sector is carried out, the prospects and opportunities for getting out of difficult external conditions are being evaluated. Measures to support Russian agricultural equipment manufacturers are being considered.
The system-forming role of the Arctic cluster in the development of the economy of the North of Russia (on the example of the Murmansk region)
Authors: Хаценко Е.С. , Лычкина Л.С. 
Published: February 2021

Представленная статья посвящена теоретико-правовым аспектам формирования экономической политики Российской Арктики, создание и регулирование Арктического экономического кластера.
The presented article is devoted to the theoretical and legal aspects of the formation of the economic policy of the Russian Arctic, the creation and regulation of the Arctic economic cluster.
Substantiation of the direction of research in the field of client-server technologies
Authors: Чевордаев И.А. 
Published: February 2021

В наше время активно развивающихся информационных технологий сложно представить работу современного офиса или какого-либо предприятия без локальной вычислительной сети (сокращенно – ЛВС). ЛВС – предназначена для обработки, хранения, а также передачи данных, и представляет собой кабельную систему объекта, например, здания или группы объектов. Развитие ЛВС позволяет всё больше использовать клиент-серверную технологию, а именно тонких клиентов для обеспечения автоматизированных рабочих мест (АРМ).
Nowadays, actively developing information technology is difficult to imagine the work of a modern office or any enterprise without a local area network (LAN). LAN – designed for processing, storage and transmission of data, and is a cable system of the object, for example, buildings or groups of objects. The development of LAN allows more and more use of client-server technology, namely thin clients to provide automated workplaces (AWP).
Electronic trade, wholesale trade, development of the electronic trade.
Accuracy of measurement of the signal information parameter in aviation and space-rocket radio systems in the presence of additive and multiplicative interference with a low level. Part 2 (Examples of frequency and arrival time measurements useful signal)
Authors: Артюшенко В.М. , Воловач В.И. 
Published: February 2021

Произведена оценка влияния флуктуационных стационарных мультипликативных помех, действующих одновременного с аддитивными помехами, на точность измерения неэнергетических параметров информационных сигналов. Показано, что мультипликативная помеха низкого уровня оказывает более сильное влияние на точность измерения времени прихода, чем на точность измерения частоты полезного сигнала. Осуществлена количественная оценка влияния мультипликативной помехи на точность измерения неэнергетических параметров полезного сигнала.
The influence of fluctuating stationary multiplicative interference acting simultaneously with additive interference on the accuracy of measurement of non-energy parameters of information signals is estimated. It is shown that low-level multiplicative interference has a stronger effect on the accuracy of the arrival time measurement than on the accuracy of the useful signal frequency measurement. A quantitative assessment of the effect of multiplicative interference on the accuracy of measurement of non-energy parameters of the useful signal is carried out.
Evaluation of the effectiveness of the activities of «KBhimmash named after A.M. Isaev» on quality assurance of rocket and space technology
Authors: Огурцова Т.С. , Асташева Н.П. 
Published: February 2021

В работе рассмотрены основные цели и задачи оценки эффективности деятельности организации по обеспечению качества ракетно-космической техники.
Представлены результаты расчета показателей эффективности деятельности «КБхиммаш им. А.М. Исаева» по обеспечению качества продукции в 2019 году с использованием методики СТО ГК Роскосмос 1023-2019.
Показано, что рассмотренная в статье методика позволяет проводить оценку эффективности деятельности «КБхиммаш им. А.М. Исаева» и разрабатывать рекомендации по повышению качества выпускаемой продукции.
The paper considers the main goals and objectives of assessing the effectiveness of an organization to ensure the quality of rocket and space technology.
Presented are the results of calculating the performance indicators of «KBhimmash im. A.M. Isaev» to ensure product quality in 2019 using the methodology of the STO GK Roscosmos 1023-2019.
It is shown that the methodology considered in the article makes it possible to assess the effectiveness of the activities of «KBhimmash named after A.M. Isaev» and develop recommendations for improving the quality of products.
The problem of user security in Wi-Fi networks
Authors: Мокану Г.С. 
Published: February 2021

Угрозы информационной безопасности в компьютерных сетях стали одной из основных проблем для владельцев ПК. При этом особое распространение этих угроз коснулось сетей WI-FI, в которых происходит как несанкционированный доступ к данным, так и только снижение уровня защиты сети. Практически все современные мобильные устройства (смартфоны, планшеты, ноутбуки и нетбуки) имеют возможность подключения к беспроводному Интернету или, точнее, к сети WI-FI, эта функция теперь является стандартной для этих устройств.
nformation security threats in computer networks have become one of the main problems for PC owners. At the same time, a particular spread of these threats affected WI-FI networks, in which both unauthorized access to data and only a decrease in the level of network protection occur. Almost all modern mobile devices (smartphones, tablets, laptops and netbooks) have the ability to connect to the wireless Internet or, more precisely, to the WI-FI network, this function is now standard for these devices.
Radical Releasing Anti-tuberculosis Agents and the Treatment of Mycobacterial Tuberculosis Infections - An Overview
Authors: Kareem Afeez I. , Malan Sarel F. , Joubert Jacques 
Published: February 2021

Abstract:The treatment and management of tuberculosis (TB) is a major global concern. Approved drugs for the treatment of TB, to date, have displayed various modes of action which can be grouped into radical releasing and non-radical releasing anti-TB agents. Radical releasing agents are of special interest because they diffuse directly into the mycobacterium cell wall, interact with the host cell DNA, causing DNA strand breakages and fatal destabilization of the DNA helix inhibiting nucleic acid synthase. As a therapeutic agent with the aforementioned activity, nitroimidazoles and most especially bicyclic nitroimidazoles are currently in clinical use for the treatment of tuberculosis. However, the approved drugs, pretomanid (PR) and delamanid (DE) are limited in their nitric oxide radical (NO•) releasing abilities to cause effective bactericidity. It is believed that their bactericidal activity can be improved by harnessing alternative strategies to increase NO• release. The last decade has witnessed the strategic inclusion of NO-donors into native drugs to improve their activities and/or reverse resistance. The rationale behind this strategy is the targeting of NO• release at specific therapeutic sites. This review, therefore, aims to highlight various radical releasing agents that may be effective in the treatment of TB. The review also investigates various structural modifications to PR and DE and suggests alternative strategies to improve NO• release as well as some applications where NO-donor hybrid drugs have been used with good therapeutic effect.
The Roles of Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Senescence
Authors: Zia Aliabbas , Farkhondeh Tahereh , Pourbagher-Shahri Ali Mohammad , Samarghandian Saeed 
Published: February 2021

:
The aging process deteriorates organs' function at different levels, causing its
progressive decline to resist stress, damage, and disease. In addition to alterations in
metabolic control and gene expression, the rate of aging has been connected with the
generation of high amounts of Reactive Oxygen Species (ROS). The essential
perspective in free radical biology is that reactive oxygen species (ROS) and free
radicals are toxic, mostly cause direct biological damage to targets, and are thus a major
cause of oxidative stress. Different enzymatic and non-enzymatic compounds in the
cells have roles in neutralizing this toxicity. Oxidative damage in aging is mostly high in
particular molecular targets, such as mitochondrial DNA and aconitase, and oxidative
stress in mitochondria can cause tissue aging across intrinsic apoptosis. Mitochondria's
function and morphology are impaired through aging, following a decrease in the
membrane potential by an increase in peroxide generation and size of the organelles.
Telomeres may be the significant trigger of replicative senescence. Oxidative stress
accelerates telomere loss, whereas antioxidants slow it down. Oxidative stress is a
crucial modulator of telomere shortening, and that telomere-driven replicative
senescence is mainly a stress response. The age-linked mitochondrial DNA mutation
and protein dysfunction aggregate in some organs like the brain and skeletal muscle,
thus contributing considerably to these post-mitotic tissues' aging. The aging process is
mostly due to accumulated damage done by harmful species in some macromolecules
such proteins, DNA, and lipids. The degradation of non-functional, oxidized proteins is a
crucial part of the antioxidant defenses of cells, in which the clearance of these proteins
occurs through autophagy in the cells, which is known as mitophagy for mitochondria.
Synthesis, Molecular Docking, and Biological Evaluation of Benzimidazole Derivatives as Selective Butyrylcholinesterase Inhibitors
Authors: Ha Zhe Y. , Ong Hoay C. , Oo Chuan W. , Yeong Keng Y. 
Published: February 2021

Background:
Benzimidazole is an interesting pharmacophore which has been extensively
studied in medicinal chemistry due to its high affinity towards various enzymes and receptors. Its derivatives
have been previously shown to possess a wide range of biological activities including anthelmintic,
antihypertensive, antiulcer, as well as anticholinesterase activity.

Objective:
The objective of this study is to search for more potent benzimidazole-based cholinesterase
inhibitors, through the modification of the 1- and 2-positions of the benzimidazole core.

Methods:
Synthesis of compounds were carried out via a 4-step reaction scheme following a previously
reported protocol. Structure-activity relationship of the compounds are established through in
vitro cholinesterase assays and in silico docking studies. Furthermore, cytotoxicity and blood brain
barrier (BBB) permeability of the compounds were also investigated.

Results:
Among the synthesised compounds, three of them (5IIa, 5IIb, and 5IIc) exhibited potent
selective butyrylcholinesterase inhibition at low micromolar level. The compounds did not show any
significant cytotoxicity when tested against a panel of human cell lines. Moreover, the most active
compound, 5IIc, was highly permeable across the blood brain barrier.

Conclusion:
In total 10 benzimidazole derivatives were synthesized and screened for their AChE and
BuChE inhibitory activities. Lead compound 5Iic, represents a valuable compound for further development
as potential AD therapeutics.