bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Acidosis &amp; it’s connection with other diseases
Authors: Datta Sagarika 
Published: November 2021

Abstract
After long observation and analysis, a connection between metabolic acidosis and migraine have been found in a female patient. She is suffering from headache from childhood. As, headache is not the primary cause it was difficult to treat. Several medicines worked when patient takes the medicine regularly. Headache is back when the drug is stopped. As the root cause was not found and not treated, there are several other problems started happening like muscle pain, weak muscle, numbness etc. Long-term metabolic acidosis has effect on the Gastroesophageal & Gastrointestinal motility. For the patient, it was observed that “Metabolic Acidosis” is the indicator. Acidosis takes place first. There can be many reasons for metabolic acidosis, but with consistent disbalance of pH level in body it damages many areas of body. And there can be several diseases added to the list. Most importantly it interrupts the connection between CNS (Central nervous system) and ENS (Enteric nervous system). Due to this disconnection the signals coming from brain cannot reach the GI tract. Very few of the signals from (instruction to contract and relaxation of the GI tract) can reach. The fact is “Less signals, less motility” and the outcome is “lazy gut. There can exist false signals, wrong interpretations of the signals.
A Spike protein-based subunit SARS-CoV-2 vaccine for pets: safety, immunogenicity, and protective efficacy in juvenile cats
Authors: Tabynov Kairat , Orynbassar Madiana , Yelchibayeva Leila , Turebekov Nurkeldi , Yerubayev Toktassyn , Matikhan Nurali , Yespolov Tlektes , Petrovsky Nikolai , Tabynov Kaissar 
Published: November 2021

Abstract
Whereas multiple vaccine types have been developed to curb the spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) among humans, there are very few vaccines being developed for animals including pets. To combat the threat of human-to-animal, animal-to-animal and animal-to-human transmission and the generation of new virus variants, we developed a subunit SARS-CoV-2 vaccine which is based on recombinant spike protein extracellular domain expressed in insect cells then formulated with appropriate adjuvants. Sixteen 8-12-week-old outbred female and male kittens (n=4/group) were randomly assigned into four treatment groups: Group 1, Antigen alone; Group 2, Sepivac SWE™ adjuvant; Group 3, aluminum hydroxide adjuvant; Group 4, PBS administered control animals. All animals were vaccinated twice at day 0 and 14, intramuscularly in a volume of 0.5 mL (Groups 1-3: 5 µg of Spike protein). On days 0 and 28 serum samples were collected to evaluate anti-spike IgG, inhibition of spike binding to angiotensin-converting enzyme 2 (ACE-2), neutralizing antibodies to Wuhan-01 SARS-CoV-2 D614G (wild-type) and Delta variant viruses, and whole blood for hematology studies. At day 28, all groups were challenged with SARS-CoV-2 wild-type virus 106 TCID50 intranasally. On day 31, tissue samples (lung, heart, and nasal turbinates) were collected for histology, viral RNA detection and virus titration. Parameters evaluated in this study included safety, immunogenicity, and protection from infection with wild-type SARS-CoV-2 virus. After two immunizations, both vaccines induced high titers of serum anti-spike IgG, ACE-2 binding inhibitory and neutralizing antibodies against both wild-type and Delta variant virus in the juvenile cats. Both subunit vaccines provided protection of juvenile cats against virus shedding from the upper respiratory tract, and against viral replication in the lower respiratory tract and hearts. These promising data warrant ongoing evaluation of the vaccine’s ability to protect cats against SARS-CoV-2 Delta variant and in particular to prevent transmission of the infection to naïve cats, before proceeding with large-scale field trials.
COVID-19, inflammatory response, iron homeostasis and toxicity: a prospective cohort study in the Emergency Department of Piacenza (Italy).
Authors: Duca Lorena , Nava Isabella , Vallisa Daniele , Vadacca Giovanni Battista , Magnacavallo Andrea , Vercelli Andrea , Capelli Patrizio , Graziadei Giovanna , Banchini Filippo 
Published: November 2021

Abstract
Dysregulation of iron metabolism and hyper-inflammation are two key points in the pathogenesis of coronavirus disease 2019 (COVID-19). Since high hepcidin levels and low serum iron can predict COVID-19 severity and mortality, we decided to investigate iron metabolism and inflammatory response in 32 COVID-19 adult patients with a diagnosis of COVID-19 defined by a positive result of RT-PCR nasopharyngeal swab, and admitted to an Italian emergency department for acute respiratory failure at different degree. Patients were stratified in 3 groups based on PaO2/FiO2 ratio at admission: 13 (41%) were normoxemic at rest and suffered from exertional dyspnea (group 1); 14 (44%) had a mild respiratory failure (group 2), and 5 (15%) a severe hypoxiemia (group 3). White blood cells were significantly higher in group 3, while lymphocytes and hemoglobin were significantly reduced. Serum iron, transferrin saturation, non-transferrin-bound iron (NTBI) and ferritin were significantly increased in group 2. All the groups showed high hepcidin levels, but in group 3 this parameter was significantly altered. It is noteworthy that in group 1 inflammatory and oxidative indices were both within the normal range. We are aware that our study has some limitations, the small number of enrolled patients and the short period of data collection, but few works have been performed in the Emergency Room. However, we strongly believe that our results confirm the pivotal role of both iron metabolism dysregulation and hyper-inflammatory response in the pathogenesis of tissue and organ damage in COVID-19 patients.
Prediction of Death After Multiple wasp Stings with a Clinical Prognostic Model
Authors: Wang Maohe , Qin Mei , Wang Amanda Y , Zhao Jia Wei , Deng Fei , Li Guisen , Wang Wei 
Published: November 2021

Abstract
Background: We aimed to assess the utility of the poisoning severity score (PSS) as early prognostic predictors in patients with wasp stings, and to explore a reliable and simple predictive tool for short-term outcomes.Methods: From January 2016 to December 2018, 363 patients with wasp stings in Suining Central Hospital were taken as research subjects. In the first 24h of hospital admission, the PSS and Chinese expert consensus on standardized diagnosis and treatment of wasp stings (CECC) were used as the criterion for severity classification, and their correlation was analyzed. The patients were divided into survival and death groups according to the state of discharge. The factors that affect outcome were analyzed by logistic regression analysis. A clinical prognostic model of death was constructed according to the risk factors, and 1000 times repeated sampling was done to include the data to verify the model internally.Results: The mortality of wasp sting patients was 3.9%. There was a correlation between PSS and CECC (r=0.435, P<0.001) for severity classification. Sex, age, number of stings, and PSS were independent risk factors for death. Based on the 4 independent risk factors screened by the above regression analysis, a nomogram model was constructed to predict the risk of death in wasp sting patients. The predicted value C-index was 0.962, and the internally verified AUC was 0.962(95%C.I. 0.936-0.988, P<0.001).Conclusions: PSS is helpful in the early classification of the severity of wasp stings. Sex, age, number of stings, and PSS were independent risk factors for death in wasp sting patients. The nomogram model established in this study can accurately predict the occurrence of the risk of death.
An Experimental Evaluation of Hybrid Learning Methodology based Internet of Things Assisted Health Care Monitoring System
Authors: Upreti Kamal , R MAHAVEERAKANNAN , Dinkar Raut Ranjana , Maurya Sudhanshu , Reddy Venkatramanan , N Thangadurai 
Published: November 2021

Abstract
In this modern world, every individual uses intelligent devices to lead a day-to-day activity intelligently. Using the latest technologies such as deep learning, the Internet of Things (IoT) forth provides standard prediction and communication abilities to the existing applications to properly provide rich support to the clients. Many commercial and non-commercial organizations almost adapt these technologies to modify their physical records digitally. This paper designed a novel health care monitoring scheme by adapting these technologies to provide an intelligent monitoring system to analyze patients over random instances with periodic intervals. This paper introduced a new learning-based scheme called Deviated Learning-based Health Analysis (DLHA), in which it combines the conventional algorithms such as Convolutional Neural Network (CNN) and the Support Vector Classification (SVM) logic in a transparent manner. The logical evaluations of the proposed approach called DLHA assessed by extracting the layers from the CNN, appending the classification logic of SVM into the CNN layers, and defining a new algorithm to predict patient health intelligently. The association of sensor-based smart device called Smart Health Indicator (SHI) provides significant support to the proposed approach with the association of intelligent sensors such as Heartbeat Analyzer, Body Temperature Estimation Sensor, Breath Sensor, Global Positioning System (GPS), and the useful Internet of Things enabled controller called ESP8266. Using this SHI kit, the patient details are monitoring instantly and reporting it to the remote server periodically to analyze the health summary without any interventions. The proposed deep learning strategy called DLHA acquires the data from the intelligent health care kit SHI and processes it using classification principles. The records collected from the kit were manipulated according to the process of the trained model generated from the previous testing samples of the patients. The dataset used in this system is generated dynamically from the real-time patient health record and processes the testing report of the patient accordingly. The processed record is appended into the dataset for further reference. The resulting section provides proper proof of the efficiency of the proposed approach in a transparent manner with graphical representations. For all this system is more significant to identify and monitor the health details of the patient in clear manner with proper specifications.
Influence of Different Encapsulating Materials on the Viability of Pediococcus Pentosaceus P107 Microencapsulated by Spray Drying
Authors: Bordini Fernanda Weber , Rosolen Michele Dutra , Luz Gabriela de Quadros da , de Oliveira Patrícia Diaz , Conceição Fabrício Rochedo , Fiorentini Ângela Maria , Silva Wladimir Padilha da , Pieniz Simone 
Published: November 2021

Abstract
This study evaluated the influence of whey isolated, and associated with pectin and xanthan gum as encapsulating agents for Pediococcus pentosaceus P107, by spray drying. In the storage test at temperatures of -20°C and 4°C the most viable microcapsule was WP (whey and pectin), but WX (whey and xanthan) presented better stability at 25°C, WX did not present itselft stable to ensure probiotic potential (< 6 Log CFU.mL-1) for 110 days. In the passage through the simulated gastrointestinal tract, the WX microcapsule stood out in all tested conditions, presenting high cellular viability. For the thermal resistance test, WP was shown to be efficient in the protection of P. pentosaceus P107 cells. The three microcapsules produced were able to protect the cellular viability of the microorganisms, as well as the drying parameters were suitable for both microencapsulation.
Adoption of Efficient Varieties, And Nitrogen Management For Improving Agronomic Attributes, And Yield of Winter Wheat
Authors: Noor Hafeez , Min Sun , Lin Wen , Gao Zhiqiang 
Published: November 2021

Abstract
This study greenhouse experiment aimed to evaluate the biochemical impact of nitrogen (N) fertilization on different wheat cultivars. The experiment included two varieties (YH-618 and YH-20410) and three nitrogen levels, (N0, N210, and N280 Kg ha–1. Our results indicated that wheat variety YH-20410 had the higher nitrogen uptake and efficiency, grain protein content, and yield at higher planting densities and will benefit farmers by forming stronger overall crops. For variety YH-20410, the soil water storage at the wintering stage was significantly highest at N280 kg ha–1, In conclusion, variety YH-20410, wheat higher dry matter accumulation of each organ at maturity stage, and the dry matter accumulation of leaf, stem + leaf sheath. Compared to N0 and N180 Kg ha–1, N210 kg ha–1 significantly increased the N harvest index by 5.0% to 19.4% and N use efficiency by 2.9% to 9.1%, but there was no significant difference in N uptake efficiency. In conclusion, variety YH-20410 was beneficial to improve the harvest index and N productivity of wheat. Variety YH-20410, has also the greater number of spike number, grains per spike and 1000-grain weight, leading to high grain yield. Among nitrogen treatments, N280 Kg ha–1 significantly increased the grain number per spike, 1000-grain weight and yield. Significantly increased grain gluten content, grain protein content and protein yield under of YH-20410 variety. In conclusion, reduced N fertilizer 280 kg ha–1 and variety YH-20410 was beneficial to the improved the leaf area index, plant height, soil water storage, dry matter accumulation, and grain yield.
Organochlorine Pesticides and Polychlorinated Biphenyls in High Mountain Lakes, Mexico
Authors: García-Solorio Liliana , Muro Claudia , Rosa Isaías De La , Amador-Muñoz Omar , Ponce-Vélez Guadalupe 
Published: November 2021

Abstract
Pollution levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were investigated in the El Sol and the La Luna alpine lakes. The lakes are located in central Mexico, in the crater of the Nevado de Toluca volcano. The El Sol and the La Luna lakes are extremely relevant in Mexico and in the world because they are recognized as pristine regions and environmental reservoirs. Samples of atmospheric aerosol, sediment, plankton, and Tubifex tubifex were collected at three different sample locations for three years (2017, 2018, and 2019) at three different times of year, meaning that the weather conditions at the time of sampling were different. Pollutants were analysed by gas chromatography–mass spectrometry with negative chemical ionisation (GC-MS/NCI). Endosulfan was the most frequent and abundant pollutant, showing the highest peaks of all. Atmospheric aerosol revealed Σ2 = 45 pg/m3, including α and β, while sediment lakes displayed α, β and endosulfan sulphate as Σ3 = 1963 pg/g, whereas plankton and Tubifex tubifex showed Σ2 = 576 pg/g and 540 pg/g for α and β respectively. Results of endosulfan ratios (α/β) and (α-β/endosulfan sulphate) suggest that both fresh and old discharges continue to arrive at the lakesThis study shows for the first time the pollution levels of OCP and PCB in high mountain lakes in Mexico. These results that must be considered by policy makers to mitigate their use in the various productive activities of the region.
Impact of Single-port Laparoscopic Approach on Postoperative Pain and Cosmesis for Acute Appendicitis: A Comparison with Multi-port Laparoscopic Approach
Authors: Kim Kyeong Eui , Cho In Soo , Bae Sung Uk , Jeong Woon Kyung , Kim Hyung Jin , Baek Seong Kyu 
Published: November 2021

Abstract
Background: Acute appendicitis is the most common surgical abdominal emergency. Single-port laparoscopic appendectomy (SPLA) has been suggested potential advantages including less postoperative pain and better cosmesis. The aim of this study was to compare the postoperative pain and cosmetic outcomes between SPLA and multi-port laparoscopic appendectomy (MPLA) for acute appendicitis.Materials and methods: The study included 47 patients who underwent SPLA and 51 patients who underwent MPLA for acute appendicitis between August 2014 and November 2017. The patient scar assessment questionnaire (PSAQ) was used to assess cosmetic outcomes. Results: MPLA involved a longer median operative time than MPLA (60 vs. 47.5 minutes, p=0.02). There were no apparent differences in the time before diet tolerance, length of hospital stay, inflammatory laboratory findings including C-reactive protein and white blood cell count, and postoperative complication rate. SPLA patients had a smaller total incision length (2.0 vs. 2.5 cm, p<0.001) and the total number of analgesics used on postoperative day 0 in the SPLA group was significantly lower than that of the MPLA group (1 vs. 1, p=0.011). The PSAQ scores showed that the SPLA group had a better overall outcome than the MPLA group with respect to total score (48 vs. 55; p = 0.026), appearance (15 vs. 18; p = 0.002) and consciousness (8 vs. 10; p = 0.005), but not in the satisfaction with appearance and symptoms subscales.Conclusion: SPLA is safe and feasible and provides better cosmetic outcomes and less analgesic requirements on the day of surgery compared to MPLA.
General Aspects of Biodegradable Biopolymers and the Polyhydroxyalkanoates' Family
Authors: Edaes Felipe Sanches , de Souza Cleide Barbieri 
Published: November 2021

Background:
Plastic polymers are ubiquitous, and life without them is practically impossible.
Despite the advantages provided by the material, conventional plastics are also harmful to the
environment and human health. Therefore, the search for alternatives, such as polyhydroxyalkanoates
(PHAs), a family of biodegradable thermoplastic polyesters naturally produced by
PHA-accumulating bacteria, such as Pseudomonas spp. and Ralstonia eutropha, through fermentative
processes, is of paramount importance.

Objectives:
In the present work, the objective of the researchers was to develop a revisional study
regarding biodegradable biopolymers and PHAs’ importance and benefits for society and the environment.

Methods:
In this review, articles published since the year 2000 related to the different aspects of
biodegradable plastics and PHAs, were accurately analyzed and reviewed. The subjects covered
ranged from conventional plastics and the problems related to their large-scale production and the
importance of biodegradable plastics, as well as PHAs, their positive aspects, and the feasibility of
their use as an alternative to replace conventional plastics. Those subjects were extensively reviewed
and concisely discussed.

Results and Conclusions:
The present study demonstrated the importance of biodegradable plastics
and PHAs’ family, its different application possibilities, and its viability as an alternative to replace
conventional plastics, since it can mimic their characteristics efficiently, with the advantage of being
biodegradable and produced from renewable sources.
Wpływ czynników demograficznych oraz długość trwania terapii rekombinowanym hormonem wzrostu na satysfakcję rodziców z leczenia dzieci z somatotropinową niedoczynnością przysadki
Authors: Grzelak Lech , Wiśniewska Anna , Ślusarz Robert 
Published: November 2021

Wstęp. Leczenie niskorosłości spowodowanej somatropinową niedoczynnością przysadki jest procesem długotrwałym, obarczonym poważnymi obostrzeniami i wymaganiami. Podawanie hormonu wzrostu w postaci codziennych iniekcji, przechowywanie leku i wizyty kontrolne są uciążliwe i wymagają zaangażowania całej rodziny w proces leczenia. Nie tylko poprawa wzrostu dziecka ale też wiele innych czynników może wpływać na satysfakcję rodziców z efektu leczenia.
Cel pracy. Celem pracy jest ocen wpływu czynników demograficznych oraz długość trwania terapii rekombinowanym hormonem wzrostu na satysfakcję rodziców z leczenia dzieci z somatotropinową niedoczynnością przysadki
Materiał i metody. W badaniu wzięło udział 69 rodziców dzieci z somatotropinową niedoczynnością przysadki leczonych hormonem wzrostu na oddziale Pediatrii, Endokrynologii, Diabetologii i Neurologii Dziecięcej w Szpitalu Dziecięcym w Toruniu. Do badań wykorzystano ankietę własną oraz standaryzowany kwestionariusz KIDSCREEN-52 wersja dla rodziców.
Wyniki i wnioski. Satysfakcja z leczenia rekombinowanym hormonem wzrostu jest zależna od osiągniętych rezultatów wzrostowych dziecka i nie wpływa na nią długotrwałość terapii. Satysfakcja rodziców z leczenia hormonem wzrostu nie zależy od wykształcenia rodziców, miejsca zamieszkania a także płci dziecka. Z badań wynika że satysfakcja zależy od wieku dziecka.
Słowa klucze: niskorosłość, terapia hormonem wzrostu, satysfakcja rodziców, somatotropinowa niedoczynność przysadki, długotrwałość terapii, czynniki demograficzne.
Ból jako jeden z głównych problemów osób leczonych operacyjnie
Authors: Budzyńska Katarzyna 
Published: November 2021

Wstęp. Ból jest jednym z najczęstszych odczuć towarzyszących w życiu każdego człowieka. Właściwie prowadzona terapia przeciwbólowa jest podstawowym prawem pacjenta.
Cel. Celem pracy była ocena stopnia i rodzaju odczuwanego bólu wśród osób dorosłych leczonych operacyjnie.
Materiały i metody. W pracy zastosowano metodę sondażu diagnostycznego, dzięki któremu pozyskano materiał do badań. Badania przeprowadzono za pomocą kwestionariusza ankiety własnego autorstwa, skali VAS oraz skróconej wersji kwestionariusza McGill.
Wyniki. Wśród badanej populacji 100% odczuwało ból występujący po zabiegu operacyjnym. Z danych procentowych wynika, że pacjenci aktualnie odczuwali najczęściej ból umiarkowany - 45,0% i łagodny - 37,0%. Po 8,0% pacjentów określiło ból jako silny lub nie występujący. Ból bardzo silny występował u 2,0% badanych. Aktualne dolegliwości bólowe wynosiły od 0 do 9 pkt wynosząc średnio M=4,28 pkt przy SD=0,216 pkt, a ból najczęściej określany był w skali od 0 do 10 na poziomie 5, na co wskazało 21,0% ankietowanych.
Kobiety istotnie częściej też niż mężczyźni odczuwały ból w ciągu ostatniego tygodnia mierzonego skalą McGill (p=0,001). Płeć różnicowała również nasilenie aktualnych dolegliwości bólowych (p=0,012), które były istotnie wyższe u kobiet niż u mężczyzn. Płeć badanych różnicowała także występowanie i nasilenie bólu sensorycznego (p=0,010), afektywnego (p-0,004) i całościowego (p=0,005) w ciągu ostatniego tygodnia.
Wykazano także, że doba po zabiegu różnicuje istotnie nasilenie aktualnego bólu w skali McGill (p=0,030) i VAS (p=0,017). Ból ten w obu skalach częściej towarzyszył osobom w II, I i III dobie po zabiegu niż pacjentom w czwartym i dalszym dniu po zabiegu.