bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long time frames to detect the impact of changing COVID-19 measures, Canada, March to July 2020
Authors: Stockdale Jessica E , Doig Renny , Min Joosung , Mulberry Nicola , Wang Liangliang , Elliott Lloyd T , Colijn Caroline 
Published: October 2021

Background
Many countries have implemented population-wide interventions to control COVID-19, with varying extent and success. Many jurisdictions have moved to relax measures, while others have intensified efforts to reduce transmission.

Aim
We aimed to determine the time frame between a population-level change in COVID-19 measures and its impact on the number of cases.

Methods
We examined how long it takes for there to be a substantial difference between the number of cases that occur following a change in COVID-19 physical distancing measures and those that would have occurred at baseline. We then examined how long it takes to observe this difference, given delays and noise in reported cases. We used a susceptible-exposed-infectious-removed (SEIR)-type model and publicly available data from British Columbia, Canada, collected between March and July 2020.

Results
It takes 10 days or more before we expect a substantial difference in the number of cases following a change in COVID-19 control measures, but 20–26 days to detect the impact of the change in reported data. The time frames are longer for smaller changes in control measures and are impacted by testing and reporting processes, with delays reaching ≥ 30 days.

Conclusion
The time until a change in control measures has an observed impact is longer than the mean incubation period of COVID-19 and the commonly used 14-day time period. Policymakers and practitioners should consider this when assessing the impact of policy changes. Rapid, consistent and real-time COVID-19 surveillance is important to minimise these time frames.
Clinical significance of 24-hour blood pressure monitoring in prediction of hypertension development in patients with gout
Authors: Gubanova M. V. , Kushnarenko N. N. , Karavaeva T. M. 
Published: October 2021

Aim.The aim of the study was to develop the model for establishing early diagnosis of hypertension in patients with gout. The model was based on data of 24-hour blood pressure monitoring.Material and Methods.A total of 69 patients with gout were enrolled in a single-stage cross-sectional prospective study. Three study groups were assigned as follows: group 1 (main group) comprised hypertensive men with gout (n = 41); group 2 (comparison group) comprised normotensive men with gout (n = 28); group 3 (control) included relatively healthy men (n = 30). Daily blood pressure monitoring was performed on an outpatient basis using a BPLab device (Peter Telegin, Russia).Results. The significant intergroup differences were found in the following parameters: lowest, mean, and highest 24-hour systolic blood pressure (SBP) values in patients of main and comparison groups (р < 0.001) and in patients of main and control groups (р < 0.001); mean and maximum 24-hour diastolic blood pressure (DBP) values in patients of main and comparison groups (р < 0.001) and in patients of main and control groups (р < 0.001); lowest, mean, and highest 24-hour pulse blood pressure (PBP) values in patients of main and comparison groups (р < 0.001) and in patients of main and control groups (р < 0.001); mean, and maximum 24-hour PBP values in patients of comparison and control groups (р < 0.001). Median values of the lowest, mean, and highest 24-hour SBP in hypertensive patients with gout were significantly higher than the corresponding values in normotensive patients with gout and healthy men of group 3 (p < 0.001). Median values of mean and maximum 24-hour DBP in main group were higher than the corresponding values in comparison group and control group (p < 0.001). Median values of the lowest, mean, and highest 24-hour PBP in hypertensive patients with gout exceeded the corresponding values of patients of control group (p < 0.001). Median values of the mean and maximum 24-hour PBP in main group exceeded the corresponding values of patients of comparison group (p < 0.001). Based on the binary logistic regression model, the prognostic algorithm for hypertension development in gout patients was created using the parameters of 24-hour blood pressure monitoring as predictors and the cut-off K value. If the value of K was > 0.54, then the hypertension development was predicted in gout patients. The sensitivity of developed diagnostic model was 0.84, and the specificity was 0.95.Conclusion.Тhe proposed model, based on the assessment of average-daily values of the lowest, mean, and highest SBP, allowed to establish early diagnosis of hypertension in patients with gout with the accuracy of up to 90%.
Age-related features of developing insulin resistance and adipocyte sensitivity to insulin in rats with induced metabolic syndrome
Authors: Naryzhnaya N. V. , Birulina Yu. G. , Kurbatov B. K. , Sirotina M. A. , Maslov L. N. 
Published: October 2021

Old age and insulin resistance accompanying metabolic syndrome are significant factors in the development of cardiovascular pathology.Aim. The aim of the study was to identify the age-related characteristics of developing insulin resistance on the body level and insulin resistance in rat adipocytes in animals with induced metabolic syndrome.Material and Methods. The study was carried out on male Wistar rats, which were divided into the following groups: group 1 (n = 14) comprised intact rats aged 150 days at the end of study; group 2 (n = 14) comprised rats aged 150 days at the end of 90-day period on diet with high contents of carbohydrates and fats (HCHFD); group 3 (n = 14) comprised intact rats aged 540 days at the end of the study; group 4 (n = 14) comprised rats aged 540 days after the end of 90-day HCHFD. Diet composition was as follows: 16% proteins, 21% fats, 46% carbohydrates including 17% fructose, 0.125% cholesterol, and replacement of drinking water with a 20%-fructose solution. At the end of the diet, body and organ weights were measured, and contents of glucose, insulin, triglycerides, serum leptin, and liver triglycerides were assessed. Epididymal adipose tissue adipocytes were isolated enzymatically. The content of reactive oxygen species (ROS) was investigated using 2,3-dihydrodichlorofluorescein diacetate. Increased ROS production and lipolysis inhibition in response to insulin were observed.Results. The signs of metabolic syndrome were observed in both age groups of HCHFD animals and included visceral obesity, hyperglycemia, and insulin resistance measured by homeostatic model assessment of insulin resistance (HOMA-IR). However, the obesity indicators were more pronounced in the group of young rats, whereas the signs of insulin resistance prevailed in older rats. Leptinemia directly correlated with HOMA-IR (rSp = 0.485, p = 0.03). Insulin resistance of adipocytes was observed in rats older than 540 days after the HCHFD.Conclusion. The obtained results suggested that age was a risk factor for the development of insulin resistance on the body level. Aging resulted in a decrease in the adipocyte sensitivity to insulin in metabolic syndrome. An increase in leptin may be a possible mechanism for worsening of insulin resistance with age.
Possibilities of predicting preclinical forms of cardiovascular diseases in young patients with type 1 diabetes mellitus using cardiac magnetic resonance imaging
Authors: Popov K. A. , Bondarenko I. Z. , Biryukova E. V. , Shatskaya O. A. , Tarbaeva N. V. , Vorontsov А. V. , Shestakova M. V. 
Published: October 2021

Aim. To identify the indicators of cardiac magnetic resonance (CMR), which have diagnostic value in the individual assessment of the cardiovascular prognosis in young patients with type 1 diabetes mellitus (T1DM).Material and Methods. The study included a total of 60 patients (29 men and 31 women) aged 18 to 36 years with a history of T1DM from 5 to 16 years, who underwent contrast-enhanced CMR. Circular strain, strain relaxation index (SRI), peak early diastolic strain rate (SRe), epicardial fat thickness (EFT), ejection fraction (EF), stroke volume (SV), end-diastolic volume (EDV), end-systolic volume (ESV), and left ventricular mass (LVM) were assessed. Echocardiography, 24-h electrocardiography (ECG), treadmill test, and NT-proBNP blood test were performed to exclude heart pathology. Statistical data processing was used to identify the relationships of changes in CMR parameters of the left ventricle and epicardial adipose tissue with disease duration, carbohydrate metabolism compensation (HbA1c), total cholesterol, and low-density lipoprotein (LDL).Results. Using the nonparametric Mann – Whitney U-test, the study showed the presence of significant differences in the values of SV, EDV, end-diastolic volume index (EDVI), and LVM in the groups of 5–10and 11–16-year duration of disease, respectively. The assessment of Spearman’s rank correlation coefficients revealed negative correlations between the values of SV, ESV, ESV index (ESVI), EDV, and LVM and T1DM duration; between the index of circular strain and blood level of HbA1c; between the values of SV, EDVI, ESVI, EDV, ESV, and LVM and blood levels of total cholesterol and LDL; between SV, EDVI, ESVI, EDV, ESV, and LVM and mean EFT in the left ventricular projection.Conclusion. The CMR-based evaluation of strain parameters may become a key in personalized identification of young T1DM patients with a high risk of adverse cardiovascular events. The thickness and distribution of epicardial adipose tissue in young patients with T1DM may have predictive value for risk stratification of developing diseases associated with atherosclerosis and chronic heart failure, which will affect the primary prevention strategy in this population.
Relationships between the expression of adipocytokine genes and the calcification of coronary arteries in patients with coronary artery disease
Authors: Gruzdeva O. V. , Belik E. V. , Dyleva Yu. A. , Brel N. K. , Kokov A. N. , Sinitskiy M. Yu. , Ivanov S. V. , Kashtalap V. V. , Avramenko O. E. , Barbarash O. L. 
Published: October 2021

Dysfunctional changes and remodeling of adipose tissue (АT) are associated with the formation of microcalcifications in the vascular wall. Biologically active substances synthesized by АT (adipocytokines) can act as promoters and inhibitors of vascular calcification development. The few available experimental and clinical studies do not fully explain the possible mechanisms of these effects.Aim. To study the relationships between the adipocytokine profiles of adipocytes in epicardial and perivascular AT with the severity of coronary artery calcification in patients with coronary artery disease (CAD).Material and Methods. A total of 125 patients with CAD aged 59 (53; 66) years were examined. The isolated adipocytes of subcutaneous adipose tissue (SAT), epicardial adipose tissue (EAT), and perivascular adipose tissue (PVAT), obtained during coronary artery bypass grafting, were used to determine gene expression and secretion of adipocytokines (adiponectin, leptin, and IL-6). Expression of adipocytokine genes was assessed using quantitative PCR with detection of products in real time (real-time qPCR); the concentration of adipocytokines in the culture medium was determined by enzyme-linked immunosorbent assay using R&D Systems kits (Canada). Coronary artery (CA) calcification degree was assessed by multislice spiral computed tomography (MSCT) method. The calcium index of CA was determined by the Agatston method using the Syngo Calcium Scoring software package (Siemens AG Medical Solution, Germany).Results. Massive coronary calcification (CC) had the highest prevalence (58.8%) in patients with CAD. The highest level of expression of the ADIPOQ gene in all types of fat stores was observed in patients with moderate/medium CС compared to those with massive CС; the maximum expression of ADIPOQ was observed in the culture of PVAT adipocytes. Expression of the LEP and IL6 genes in massive CC was higher, with the maximum values in the culture of EAT adipocytes relative to SAT and PVAT adipocytes. Decreases in the levels of ADIPOQ mRNA and its secretion, increases in the levels of mRNA of LEP and IL6 and their secretion in adipocytes of the EAT and PVAT were associated with the development of СС in patients with CAD.Conclusion. Proinflammatory adipokines produced by adipocytes of patients with CAD during hypoxia induced vascular calcification by stimulating oxidative stress, osteoblast differentiation, apoptosis, and proliferation of smooth muscle cells. Endothelial cells, when stimulated with proinflammatory adipocytokines, tended to transform into osteoblasts, which further aggravated the degree of vascular inflammation and calcification.
Relationships between parameters of cardiorespiratory function and bioimpedance analysis in young patients with type 1 diabetes mellitus
Authors: Vengrzhinovskaya O. I. , Bondarenko I. Z. , Shatskaya O. A. , Kosharnaya R. S. , Shestakova M. V. 
Published: October 2021

Type 1 diabetes mellitus (T1DM) triggers disruption of oxygen transport system in patients. The maximum oxygen consumption (VO2 max) during spiroergometry depends on the functional capabilities and composition of the body. Moreover, VO2 max may be considered a predictor of pathological changes in cardiovascular system.Aim. The purpose of the study was to investigate the compositional body characteristics and functional cardiorespiratory parameters in T1DM patients.Material and Methods. The study comprised 30 patients with T1DM (average age of 25.5 ± 8.1 years) and 10 patients of control group (average age of 27 ± 9 years). Patients received spiroergometry examination according to B. Bruce protocol and bioimpedansometry using the Inbody 770 apparatus. The study showed that T1DM patients reached anaerobic threshold faster (p = 0.032) and had significantly lower VO2 max and carbon dioxide emission compared to patients without diabetes (p = 0.021; p = 0.034) whereas exercise tolerance did not significantly differ compared with the corresponding value in control group. Patients with higher muscle mass i.e. muscle tissue weight (kg) according to bioimpedance measurements had higher values of VO2 max (L) in control group (p = 0.017) and in group of T1DM patients (p = 0.028).Conclusions: Young T1DM patients without cardiovascular diseases had significantly less effective cardiorespiratory system compared with that in people without diabetes even in those with high exercise tolerance. Rapid achievement of anaerobic threshold with preserved performance efficiency was a sign of unfavorable prognosis. Body mass index and lean body mass did not significantly affect the performance parameters in young T1DM patients. Screening of spiroergometry parameters may be used for identification of young T1DM patients at high risk of unfavorable cardiovascular diseases including chronic heart failure.
Assessment of significance of erythrocyte indices as metabolic and microvascular complications markers in patients with type 1 and type 2 diabetes mellitus
Authors: Kostitsyna J. A. , Musina N. N. , Arzhanik M. B. , Saprina T. V. 
Published: October 2021

Erythrocyte morphology is a reflection of both physiological and pathological reactions occurring in the body of patients with diabetes mellitus (hyperglycemia, adipose tissue dysfunction, dyslipidemia, lipid peroxidation, angiopathy, diabetic nephropathy, etc.). There are no available data in the literature that would characterize gradual and progressive changes in the morphology of the erythron system in patients with diabetes mellitus, the more so any analysis of the relationships with pathogenetic factors affecting them.Aim. The aim of the study was to evaluate the nature of erythrocyte index relationships with vascular and metabolic complications of type 1 and type 2 diabetes mellitus. The main objective of the study was to determine the changes in red blood cell indices at different stages of diabetic microangiopathies and in the presence of different indicators of metabolic control.Material and Methods. A total of 122 patients were enrolled in a single-stage, single-center, comparative, controlled study. Patients were assigned to three groups: group 1 comprised patients with type 1 diabetes mellitus (n = 41); group 2 comprised patients with type 2 diabetes mellitus (n = 67); and group 3 comprised control patients (n = 14). Statistical processing of the results was performed using the SPSS Statistics 20 software.Results. Patients with diabetes mellitus are characterized by qualitative changes in the erythron system manifesting as changes in red blood cell indices.The study identified the significant associations between the changes in erythron system (erythrocyte indices) and various phenotypic features of patients with type 1 and type 2 diabetes mellitus, namely: the duration of diabetes of over 10 years, type 2 diabetes mellitus in combination with obesity, and the presence of dyslipidemia, diabetic retinopathy, and poorly controlled diabetes mellitus if glycated hemoglobin exceeded 8% with a subsequent corresponding increase per each 1%.Conclusion. Additional studies are required to implement these markers, in particular, a red cell distribution width, as risk factors for unfavorable prognosis i.e. the risk of developing various diabetes mellitus complications.
RESILIENSI KOMUNITAS MISKIN DI PEDESAAN MENGHADAPI PANDEMI COVID-19
Authors: Hidayat Kintan Ayu Septiani , Nurmala K. Pandjaitan  
Published: October 2021

Pandemi Covid-19 yang terjadi sejak awal tahun 2020 sampai saat ini memberikan dampak buruk bagi kesehatan, sosial, dan ekonomi. Menghadapi gangguan akibat bencana ini komunitas harus mampu beradaptasi agar dapat bertahan hidup, terutama komunitas miskin yang merupakan kelompok rentan. Komunitas miskin merupakan komunitas yang tidak berdaya serta memiliki keterbatasan ekonomi. Ancaman besar akibat pandemi ini ialah akan meningkatkan kemiskinan akibat guncangan ekonomi dan pembatasan aktivitas. Tujuan penelitian ini akan mengkaji ketahanan komunitas miskin di pedesaan menghadapi pandemi yang ditinjau melalui kapasitas adaptasi dan tindakan kolektif komunitas. Metode yang digunakan adalah survei menggunakan instrumen kuesioner, observasi, dan wawancara mendalam. Pemilihan responden menggunakan teknik sample random sampling dan didapatkan sample sebanyak 40 responden. Hasil penelitian menunjukkan bahwa ketahanan komunitas miskin di pedesaan tidak terbangun karena komunitas tidak mampu beradaptasi dalam menghadapi pandemi dan tidak adanya upaya kolektif yang dilakukan untuk mengatasi permasalahan bersama selama pandemi. Komunitas cenderung mengandalkan bantuan dan dukungan eksternal dari pihak luar komunitas untuk bertahan menghadapi pandemi Covid-19.
Kata Kunci: Kapasitas adaptasi, Aksi kolektif, Resiliensi komunitas
IMPLEMENTASI PELAYANAN TERPADU SATU PINTU DALAM MEWUJUDKAN PELAYANAN PRIMA DI KABUPATEN TRENGGALEK
Authors: Tyasotyaningarum Berlian , Putri Arsita 
Published: October 2021

Abstrak Penelitian ini menggunakan metode kualitatif, penelitian ini digambarkan secara jelas dan mendetail terkait implementasi (PTSP) dalam mewujudkan pelayanan prima di Dinas Penanaman Modal Dan Pelayanan Terpadu Satu Pintu Kabupaten Trenggalek. Data diperoleh dari sumber primer dan sekunder. Informan dalam penelitian ini terdiri dari empat (4) informan kunci, tiga (3) informan pendukung, dan adapun teknik pengumpulan data dalam penelitian ini dengan observasi, wawancara, dokumentasi. Hasil penelitian menunjukan secara keseluruhan Implementasi PTSP di Dinas Penanaman Modal Dan Pelayanan Terpadu Satu Pintu untuk kepengurusan pelayanan perizinan sudah dilakukan sesuai dengan SOP dan regulasi yang ada. Komunikasi yang dilakukan antar atasan dan bawahan tentang implementasi juga sudah sesuai dengan aturan, dan komukasi yang dilakukan dengan masyarkat pun juga sudah menyeluruh. Serta untuk waktu penyelesaian, dan biaya terkait pelayanan perizinan juga sudah diatur sesuai dengan SOP yang sudah berlaku. Dilengkapi juga berbagai fasilitas yang lengkap yang ada di Dinas Penanaman Modal Dan Pelayanan Terpadu Satu Pintu sebagai penunjang kepuasan dan kenyamanan masyarakat. Kata Kunci: Implementasi Progam, PTSP, Pelayanan Prima. Abstract This study uses a qualitative method, this research is described clearly and in detail related to the implementation (PTSP) in realizing excellent service at the Office of Investment and One Stop Integrated Services, Trenggalek Regency. Data obtained from primary and secondary sources. The informants in this study consisted of four (4) key informants, three (3) supporting informants, and the data collection techniques in this study were observation, interviews, and documentation. The results of the study show that the overall implementation of PTSP in the Office of Investment and One Stop Integrated Services for the management of licensing services has been carried out in accordance with existing SOPs and regulations. Communication between superiors and subordinates regarding implementation is also in accordance with the rules, and communication with the community is also comprehensive. As well as for the completion time, and costs related to licensing services have also been regulated in accordance with the SOP that is already in effect. It is also equipped with various complete facilities available at the Investment Service and One-Stop Integrated Service as a support for community satisfaction and comfort. Keywords: Program Implementation, PTSP, Excellent Service.
Interdisciplinary approach to the management of a patient with Sjogren’s syndrome: a clinical case
Authors: Emelyanova N. Y. , Kozyrieva T. E. , Stepanova O. V. , Zorenko N. V. 
Published: October 2021

Dryness of the mucous membranes (in mouth, nose, genitals in women) and skin are the most common complaints of patients with Sjogren’s disease — a multisystem immune‑mediated disorder that causes anxiety and concern associated with the difficulties of initial diagnosis. The authors present a clinical case of a patient with primary Sjogren’s syndrome, a large number of symptoms of digestive diseases, complaints of dryness of mucous membranes, in particular the oral cavity. The diagnosis was confirmed by allied specialists such as ophthalmologist, gynecologist, rheumatologist, dentist. Detailed dental examination revealed the main dental complaints (constant dry mouth, galitos, changes in taste), clinical condition (dryness of the red border of the lips, swelling of the oral mucosa, changes in the relief of the gums), decreased secretory activity and significant reduction of unstimulated salivation with a moderate level of stimulated salivation. It is noted that a significant decrease in sialometry (0.01 ml per minute) and functional activity of the small salivary glands (up to 18) confirms the presence of true xerostomia. Micro‑crystallization of saliva revealed disorganization of irregularly shaped structures, as well as a significant number of organic inclusions, which indicates a violation of homeostasis in the oral cavity. Given the results of ultrasound examination of the large salivary glands and the absence of enlargement and swelling of the glands during clinical examination, we can assume that the destructive damage to the glands is not so pronounced, evacuation function of the gland is not reduced, but the amount of secretion is significantly reduced. To provide medical aid to patients with Sjogren’s syndrome, the accessibility of the qualified consultation is important and required, with conduction of comprehensive examinations by allied specialists, including a dentist.