bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital literacies in higher education
Authors: Monteiro Angélica , Leite Carlinda 
Published: March 2021

La digitalización de las instituciones de educación superior (IES), debido a la imposibilidad de clases presenciales y tutoría, causada por COVID-19, puso de manifiesto la necesidad de repensar las oportunidades y los obstáculos para el desarrollo de habilidades de los estudiantes. Basado en el marco de alfabetización digital de Martin y Grudziecki (2006), se desarrolló un estudio con el objetivo de identificar las percepciones de los estudiantes con respecto a las habilidades digitales que poseen, los usos y efectos de esto en el desarrollo personal y habilidades sociales. La recopilación de datos, utilizando un cuestionario en línea, tuvo lugar al comienzo del cierre de IES en Portugal. Los resultados apuntan a un dominio de las habilidades de búsqueda y edición de datos y a una menor capacidad para crear y desarrollar nuevas soluciones digitales. La mayoría de los estudiantes informaron que las tecnologías digitales se usaron principalmente para la comunicación institucional y entre pares, pero no para el desarrollo de redes y habilidades de aprendizaje permanente. La falta de participación de muchos docentes en el apoyo pedagógico disponible es un obstáculo para una transformación digital adecuada en la educación superior, tanto en tiempos de crisis como en el futuro.
The digitalisation of higher education institutions (HEI), due to the impossibility of face-to-face classes and tutoring, caused by COVID-19, evidenced the need to rethink opportunities and obstacles for the development of digital skills among students. Based on the digital literacy framework by Martin and Grudziecki (2006), a study was developed with the aim of identifying the perceptions of university students regarding the digital skills they possess, as well as the uses and effects of digital literacy in the development of personal and social skills. Data collection, using an online questionnaire, took place during the initial closing period of HEI in Portugal. The results point to an almost widespread mastery of search and data editing skills and to a lesser ability to create and develop new digital solutions. Most students reported that digital technologies were used [before the crisis] mainly for institutional communication and between peers, but not for the development of networking and lifelong learning skills. The lack of involvement of many teachers in the available pedagogical support is an obstacle to an adequate digital transformation in higher education, both in times of crisis and in the future.
Análisis del proceso metodológico en programas de educación superior en modalidad virtual
Authors: Díaz Guillen Paula Andrea , Andrade Arango Yamilhet , Hincapié Zuleta Ana María , Uribe Uran Adriana Patricia 
Published: March 2021

El propósito de este artículo consiste en identificar las características metodológicas de los programas virtuales de educación superior en instituciones colombianas. Este objetivo se deriva de la carencia de lineamientos acerca de cómo implementar procesos de educación virtual a nivel de pregrado y posgrado en un país en vía de desarrollo como Colombia. Para lograr este objetivo, se llevó a cabo una investigación de enfoque cualitativo en una muestra a propósito de 10 instituciones de educación superior en Colombia, las cuales tienen una oferta importante de programas de pregrado y posgrado para la modalidad virtualidad. Como resultados se reflejan modelos educativos que se transforman en torno a la realidad educativa y a las formas de concebir, planear, implementar y evaluar desde estrategias y alternativas metodológicas que conllevan al acceso, la permanencia y la democratización de la educación en miras a la calidad y la inclusión digital.
The purpose of this article is to identify the methodological characteristics of virtual higher education programs in Colombian institutions. This objective is derived from the lack of guidelines on how to implement virtual education processes at the undergraduate and graduate levels in a developing country like Colombia. To achieve this objective, a qualitative approach research was carried out in a sample of 10 higher education institutions in Colombia, which have an important offer of undergraduate and graduate programs for the virtual modality. The results reflect educational models that are transformed around the educational reality and the ways of conceiving, planning, implementing and evaluating from strategies and methodological alternatives that lead to access, permanence and democratization of education in view of quality and digital inclusion.
Oleanolic Acid, Ursolic Acid and Apigenin from Ocimum basilicum as Potential Inhibitors of the SARS-CoV-2 Main Protease: A Molecular Docking Study
Authors: Matondo Aristote , Kilembe Jason T. , Ngoyi Etienne M. , Kabengele Carlos N. , Kasiama Giresse N. , Lengbiye Emmanuel M. , Mbadiko Clement M. , Inkoto Clement L. , Bongo Gedeon N. , Gbolo Benjamin Z. , Falanga Clarisse M. , Mwanangombo Domaine T. , Opota Daniel O. , Tshibangu Damien S. T. , Tshilanda Dorothée D. , Ngbolua Koto-te-Nyiwa , Mpiana Pius T. 
Published: March 2021

Aim: The present study aims at identifying potential inhibitors from a set of ten compounds from Ocimum basilicum against the SARS-CoV-2 main protease, the chymotrypsin-like protease (3CLpro).
Materials and Methods: Computational studies by molecular docking (Autodock tool) were used to obtain the scoring function of ten phytochemicals in interaction with the SARS-CoV-2 main protease. The pharmacokinetic behavior of the high-docking score compounds was addressed by using SwissADME and pkCSM webservers.
Results: Three high-docking score ligands were identified as hit compounds mainly the oleanolic acid (-8.55 kcal/mol), the ursolic acid (-8.21 kcal/mol) and apigenin (-7.52 kcal/mol). Their pharmacokinetic profile revealed that they have good therapeutic profile of druggability and safe. The biological activities of the three compounds especially their anti-inflammatory properties in relation with the excessive production of proinflammatory cytokines in the most severe form of the COVID-19 were also highlighted.
Conclusion: COVID-19 outbreak is a serious public health threat that requires immediate action. In order to combat this pandemic, several strategies are used and the identification of potential inhibitors of the main protease of the virus is one of the widely used strategies. Here, three potential inhibitors from Ocimum basilicum plant (leaves) were pinpointed. Further in-vitro and in-vivo studies are needed that will clarify the role of Ocimum basilicum for the management of COVID-19 disease.
Synthesis, Characterization and Preliminary Biological Evaluation of New 3 and 4-nitro Isoindoline-1, 3-dione/phthalimide Analogues
Authors: Sankhe Sharad , Chindarkar Nitesh 
Published: March 2021

Aims: To synthesize new nitroisoindoline-1,3-diones analogues and evaluate their preliminary biological activities
Methodology: New isoindoline-1,3-diones analogues were synthesized by coupling phthalic anhydride derivatives with appropriate aromatic amines. Newly synthesized heterocyclic compounds were evaluated for their in vitro antibacterial activity against gram-positive bacterial strains and gram-negative bacterial strains. They were also tested for their in vitro antifungal activity against fungi strains. Determination of the preliminary antibacterial and antifungal activity were investigated using agar-dilution method. The structures of newly synthesized analogues were elucidated by 1H and 13C-NMR techniques.
Results: Bioassay indicated that some of the newly synthesized isoindoline-1,3-dione analogues shows moderate biological activities.
Conclusion: Newly synthesized analogues can be used as antibacterial or antifungal agents on modifications.
Semiconducting Polymers Based on Isoindigo and Its Derivatives: Synthetic Tactics, Structural Modifications, and Applications
Authors: Wei Xuyang , Zhang Weifeng , Yu Gui 
Published: March 2021

AbstractThe past few decades have witnessed the tremendous development of semiconducting polymers in electronic applications, which is inextricably related to the diversity of polymer structure. The change of polymer structure significantly influences the polymer packing, thin film morphology, and other optoelectronic properties, thus meeting the need for different device applications. With the development of synthetic chemistry and theoretical computation, many high‐performance building blocks and polymers have emerged. Among them, isoindigo‐ and isoindigo derivatives‐based polymers are widely studied in various fields of organic electronics, and many of them showed excellent properties. This review summarizes the synthetic tactics of isoindigo‐derived monomers and polymers. Moreover, the structural modification strategies of polymers are discussed in detail, including the modification of isoindigo derivatives and the regulation of polymer type. Using isoindigo‐derived polymers, various applications, such as organic field‐effect transistors, chemical sensors, organic electrochemical transistors, organic phototransistors, organic photovoltaics, organic thermoelectrics, organic spin valves, and biophotonic applications, are introduced to illustrate the important effects of structural modification.
Screening Supported Amine Sorbents in the Context of Post‐combustion Carbon Capture by Vacuum Swing Adsorption
Authors: Krishnamurthy Shreenath , Boon Jurriaan , Grande Carlos , Lind Anna , Blom Richard , de Boer Robert , Willemsen Hans , de Scheemaker Gabriel 
Published: March 2021

AbstractThe aim of this work was to evaluate the performance of three different supported amine sorbents in a 6‐step vacuum swing adsorption (VSA) cycle through process simulation and optimization for a representative post‐combustion CO2 capture system. Detailed process optimization revealed that all the adsorbents were able to achieve the desired purity‐recovery targets. The best performing adsorbent in terms of productivity was Lewatit with a productivity of 0.48 mol m−3 ads s−1. All the adsorbents exhibited similar minimum specific energy value of around 1 MJ kg−1 on an electric basis.
Dual‐Propelled Sporopollenin‐Exine‐Capsule Micromotors for Near‐Infrared Light Triggered Degradation of Organic Pollutants
Authors: Pan Sihao , Ren Jiaoyu , Ma Enhui , Wang Ke , Yang Sicheng , Wang Hong 
Published: March 2021

AbstractTowards on‐site degradation of organic pollutants, dual‐propelled sporopollenin‐exine‐capsule (SEC) micromotors loaded with horseradish peroxidase (HRP) have been developed. The magnetic propulsion of SEC micromotors enables them to follow predesignated paths to arrive the pollution site, while the chemical propulsion on the site accelerates the degradation process taking advantage of the fluid mixing effect induced by their movement and bubble generation. Near‐infrared (NIR) light is employed to trigger the rupture of the magnetic polydopamine (PDA) outer coating and release the platinum‐coated SECs loaded with HRP enzyme. The dual propulsion system combined with the biocompatible nature of the components paves the way for on‐site bioremediation of organic pollutants.
Investigating the morphological and genetic divergence of arctic char (Salvelinus alpinus)populations in lakes of arctic Alaska
Authors: Klobucar Stephen L. , Rick Jessica A. , Mandeville Elizabeth G. , Wagner Catherine E. , Budy Phaedra 
Published: March 2021

AbstractPolymorphism facilitates coexistence of divergent morphs (e.g., phenotypes) of the same species by minimizing intraspecific competition, especially when resources are limiting. Arctic char (Salvelinussp.) are a Holarctic fish often forming morphologically, and sometimes genetically, divergent morphs. In this study, we assessed the morphological and genetic diversity and divergence of 263 individuals from seven populations of arctic char with varying length‐frequency distributions across two distinct groups of lakes in northern Alaska. Despite close geographic proximity, each lake group occurs on landscapes with different glacial ages and surface water connectivity, and thus was likely colonized by fishes at different times. Across lakes, a continuum of physical (e.g., lake area, maximum depth) and biological characteristics (e.g., primary productivity, fish density) exists, likely contributing to characteristics of present‐day char populations. Although some lakes exhibit bimodal size distributions, using model‐based clustering of morphometric traits corrected for allometry, we did not detect morphological differences within and across char populations. Genomic analyses using 15,934 SNPs obtained from genotyping by sequencing demonstrated differences among lake groups related to historical biogeography, but within lake groups and within individual lakes, genetic differentiation was not related to total body length. We used PERMANOVA to identify environmental and biological factors related to observed char size structure. Significant predictors included water transparency (i.e., a primary productivity proxy), char density (fish·ha‐1), and lake group. Larger char occurred in lakes with greater primary production and lower char densities, suggesting less intraspecific competition and resource limitation. Thus, char populations in more productive and connected lakes may prove more stable to environmental changes, relative to food‐limited and closed lakes, if lake productivity increases concomitantly. Our findings provide some of the first descriptions of genomic characteristics of char populations in arctic Alaska, and offer important consideration for the persistence of these populations for subsistence and conservation.
Childhood maltreatment and clinical response to mood stabilizers in patients with bipolar disorder
Authors: Cascino Giammarco , D'Agostino Giulia , Monteleone Alessio Maria , Marciello Francesca , Caivano Vito , Monteleone Palmiero , Maj Mario 
Published: March 2021

AbstractObjectiveThe association between childhood maltreatment (CM) and clinical response to mood stabilizers has been scarcely investigated in bipolar disorder (BD). Therefore, we assessed whether CM affects the response to lithium or anticonvulsant treatments in BD patients.MethodsA retrospective assessment of clinical response to mood stabilizers was conducted in 97 euthymic patients with BD by means of the Alda scale. History of CM was investigated through the Childhood Trauma Questionnaire.ResultsThirty‐seven patients (24 with a history of CM and 13 without CM) were on stable lithium treatment while sixty (35 with a history of CM and 25 without CM) were on stable anticonvulsant treatment. Clinical response to drug treatment did not differ between BD with CM and those without CM in the whole sample as well as in the anticonvulsant‐treated subgroup. In the lithium‐treated subgroup, a significant negative correlation emerged between childhood physical abuse and clinical response and patients with CM showed a significantly reduced Alda score.ConclusionsIn BD patients, CM did not influence the clinical response to anticonvulsant mood stabilizers whereas it was associated with a poorer response to lithium with childhood physical abuse playing a major role in this effect.
Postprandial rise of essential amino acids is impaired during critical illness and unrelated to small‐intestinal function
Authors: van Gassel Rob J. J. , van de Poll Marcel C. G. , Schaap Frank G. , Plummer Mark , Deane Adam , Olde Damink Steven W. M. 
Published: March 2021

AbstractBackgroundPostprandial rise of plasma essential amino acids (EAAs) determines the anabolic effect of dietary protein. Disturbed gastrointestinal function could impair the anabolic response in critically ill patients. Aim was to investigate the postprandial EAA response in critically ill patients and its relation to small‐intestinal function.MethodsTwenty‐one mechanically ventilated patients and 9 healthy controls received a bolus containing 100 ml of a formula feed (Ensure) and 2 g of 3‐O‐Methyl‐d‐glucose (3‐OMG) via postpyloric feeding tube. Fasting and postprandial plasma concentrations of EAAs, 3‐OMG, total bile salts, and the gut‐released hormone fibroblast growth factor 19 (FGF19) were measured over a 4‐hour period. Changes over time and between groups were assessed with linear mixed‐effects analysis. Early (0–60 minutes) and total postprandial responses are summarized as the incremental area under the curve (iAUC).ResultsAt baseline, fasting EAA levels were similar in both groups: 1181 (1055–1276) vs 1150 (1065–1334) μmol·L−1, P = .87. The early postprandial rise in EAA was not apparent in critically ill patients compared with healthy controls (iAUC60, −4858 [−6859 to 2886] vs 5406 [3099–16,853] µmol·L−1·60 minutes; P = .039). Impaired EAA response did not correlate with impaired 3‐OMG response (Spearman ρ 0.32, P = .09). There was a limited increase in total bile salts but no relevant FGF19 response in either group.ConclusionPostprandial rise of EAA is blunted in critically ill patients and unrelated to glucose absorption measured with 3‐OMG. Future studies should aim to delineate governing mechanisms of macronutrient malabsorption.
Compact triple‐mode HMSIW balanced passband filter with intrinsic common‐mode suppression
Authors: Zhu Jia‐ming , Deng Hong‐wei , Han Yang‐kun , Xing Si‐bei , Han Wei 
Published: March 2021

AbstractIn this article, a compact triple‐mode balanced passband filter with intrinsic common‐mode (CM) suppression is designed by using a single isosceles right triangle perturbed half‐mode substrate integrated waveguide (HMSIW) cavity. The perturbation metallic vias are introduced to tune the first three resonant modes of HMSIW cavity to form a passband. Furthermore, the planar differential microstrip‐pin feed structure is designed to excite the perturbed substrate integrated waveguide cavity. Under CM operation, when the substrate's height is less than λg/4, the space between perfect electric conductor and perfect magnetic conductor cannot transmit electromagnetic wave, so CM noise can effectively cut off at the planar differential feed structure in a wide frequency range. Finally, a prototyped prototype at 4.5 GHz is designed and fabricated, and measured results show good agreement with simulated ones.
Removal of off‐resonance xenon gas artifacts in pulmonary gas‐transfer MRI
Authors: Willmering Matthew M. , Cleveland Zackary I. , Walkup Laura L. , Woods Jason C. 
Published: March 2021

PurposeHyperpolarized xenon (129Xe) gas‐transfer imaging allows different components of pulmonary gas transfer—alveolar air space, lung interstitium/blood plasma (barrier), and red blood cells (RBCs)—to be assessed separately in a single breath. However, quantitative analysis is challenging because dissolved‐phase 129Xe images are often contaminated by off‐resonant gas‐phase signal generated via imperfectly selective excitation. Although previous methods required additional data for gas‐phase removal, the method reported here requires no/minimal sequence modifications/data acquisitions, allowing many previously acquired images to be corrected retroactively.Methods129Xe imaging was implemented at 3.0T via an interleaved three‐dimensional radial acquisition of the gaseous and dissolved phases (using one‐point Dixon reconstruction for the dissolved phase) in 46 human subjects and a phantom. Gas‐phase contamination (9.5% ± 4.8%) was removed from gas‐transfer data using a modified gas‐phase image. The signal‐to‐noise ratio (SNR) and signal distributions were compared before and after contamination removal. Additionally, theoretical gaseous contaminations were simulated at different magnetic field strengths for comparison.ResultsGas‐phase contamination at 3.0T was more diffuse and located predominantly outside the lungs, relative to simulated 1.5T contamination caused by the larger frequency offset. Phantom experiments illustrated a 91% removal efficiency. In human subjects, contamination removal produced significant changes in dissolved signal SNR (+7.8%), mean (–1.4%), and standard deviation (–2.3%) despite low contamination. Repeat measurements showed reduced variance (dissolved mean, –1.0%; standard deviation, –8.4%).ConclusionOff‐resonance gas‐phase contamination can be removed robustly with no/minimal sequence modifications. Contamination removal permits more accurate quantification, reduces radiofrequency stringency requirements, and increases data consistency, providing improved sensitivity needed for multicenter trials.
Consulting ‘Dr. Google’ for minimally invasive urological oncological surgeries: A contemporary web‐based trend analysis
Authors: Cacciamani Giovanni E. , Sebben Marco , Tafuri Alessandro , Nassiri Nima , Cocci Andrea , Russo Giorgio I , Hung Andrew , de Castro Abreu Andre Luis , Gill Inderbir S. , Artibani Walter 
Published: March 2021

ABSTRACTPURPOSETo determine web‐based public interest in minimally invasive surgery (MIS) specifically for urological oncological surgical procedures and how interest in robotics and laparoscopy compares over time.MATERIALS AND METHODSWorldwide search‐engine trend analysis included electronic Google queries of MIS urologic options from January 2004 to August 2019, worldwide. Join‐point regression was performed. Comparison of annual relative search volume (ARSV) and average annual percentage change (AAPC) were analysed to assess loss or gain of interest. Evaluations were made regarding 1) penetrance of interest for MIS in Urology; 2) how MIS urologic procedures compared over time; and 3) which were the top related queries to searches for urologic oncology procedures.RESULTSIncreased interest was found for all of the MIS procedures evaluated. Mean ARSV for robotic approach was higher for the search term 'prostatectomy” (44.8 vs. 13.5; p < 0.001) and 'partial nephrectomy” (27.1 vs.11.5; p = 0.02). No statistical difference was found for the search terms 'cystectomy” or 'nephrectomy”. The analysis of mean (∆‐ARSV) of MIS procedures measured between the first and last 12 months of the study period showed an increased interest with a more pronounced ∆‐ARSV for robotic procedures. The top related searches for all surgical procedures were examined showing an increasing inquisitiveness with regards of type of urological cancers, treatment options, type of surgery and prognostic outcomes.CONCLUSIONSPeople are increasingly searching the web for MIS urological procedures. A growing appeal for robotics is demonstrated, especially for prostatectomy and partial nephrectomy where the robotic approach is gaining traction, suggesting a shift in mind‐set amongst people seeking urological healthcare information.
Spectral form factor for time-dependent matrix model
Authors: Mukherjee Arkaprava , Hikami Shinobu 
Published: March 2021

Abstract
The quantum chaos is related to a Gaussian random matrix model, which shows a dip-ramp-plateau behavior in the spectral form factor for the large size N. The spectral form factor of time dependent Gaussian random matrix model shows also dip-ramp-plateau behavior with a rounding behavior instead of a kink near Heisenberg time. This model is converted to two matrix model, made of M1 and M2. The numerical evaluation for finite N and analytic expression in the large N are compared for the spectral form factor.