bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cathlab department diagnostic reference levels and trigger values analysis
Authors: Cortez Angela , Santos Joana , Costa João , Paulo Graciano 
Published: August 2021

Abstract

Background
This study aims to assess the examination dose values in interventional cardiology procedures to establish diagnostic reference levels and analyse number of procedures that exceed trigger values.

Methods
Data about the procedure type, operator identification, procedure access, patient characteristics (gender, age and weight), fluoroscopy time (min), Kerma Area Product - PKA (Gy.cm2), was retrospectively collected, for a period of 12 months. Patients were categorised in three weight groups: low ( &lt; 65 kg), standard (65–75kg) and high ( &gt; 75 kg).

Results
he majority of the 2540 examinations were diagnostic procedures (65%) and the more common access was via the right radial artery (92%). Significant differences (P &lt; 0.05) in fluoroscopy time and PKA values, between procedure access, patient weight group and type of procedure were found. The trigger level of PKA ( &gt; 300Gy.cm2) value was exceeded in 0.5% of the procedures, lower than the incidence found in the literature. The local DRL values for diagnostic and therapeutical procedures were respectively 39 and 111 Gy.cm2, in line with values published in the literature.

Conclusions
The dose distribution is in line with the ones found in the literature. The percentage of patients that exceed one of trigger levels is lower when compared with the literature, however a patient follow-up plan should be established.
The impact of lack of affection and poor social ties in the nurses work environment: evidence from a Portuguese sample
Authors: Ferreira Margarida , Vidal Diogo Guedes , Ferreira Carlos , Gregório Susana 
Published: August 2021

Abstract

Background
Significant evidence has pointed out the positive impact of caring with love. Nurses are the healthcare professionals whose love gives a self–sacrificing spirit. However, little is still know about how lack of affection and unhealthy social ties affects Nurses in the work environment. This study sought to explore the association between affection, social ties and work environment.

Methods
Descriptive, correlational and cross-sectional study conducted with 36 Nurses of a private hospital in a city of Porto, Portugal. The ‘Fantastic Lifestyle’ and ‘Nursing Practice Work Environment’ scales, adapted and validated to the Portuguese population, with good internal consistency and reliability, were applied. The study was conducted between February and March 2020. Statistical analyses were performed through SPSS.

Results
Female nurses (80.6%), single (61.1%) and with an average age of 29 years (SD = 5.15) prevailed. 94.4% almost always have someone to talk to about important matters and 88.9% report that they almost always gave and received affection. Weak social ties negatively affect the perception that doctors and nurses have a good working relationship (χ2 = 8.145; P = 0.043) and collaboration (χ2 = 8.145; P = 0.043), resulting in a depreciation of colleagues skills (χ2 = 8.603; P = 0.014). Lack of affection negatively affects the perception of doctors and nurses collaboration (χ2 = 17.708; P = 0.001), the updating of nursing care plans (χ2 = 9.267; P = 0.008) and the relevance of nursing diagnosis applicability (χ2 = 7.650; P = 0.022).

Conclusions
Findings encourage the need to pay attention to nurses’ affection level and social ties strengthen, once the imbalance of one of these dimensions negatively influences the quality of work environment, impacting the quality of health care provided.
Analysis of hemodynamics response in prefrontal cortex during motor and cognitive dual-task—fNIR study
Authors: Saraiva Marina , Vilas-Boas João Paulo , Castro Maria António 
Published: August 2021

Abstract

Background
Most of the processes occurring in the human body, need brain oxygenation. Motor and cognitive systems require neural resources and during a dual-task performance the demand on the brain increases. This study aimed to analyse the brain activation in static postural control during motor and cognitive dual-tasks.

Methods
Using Functional near-infrared spectroscopy (fNIR), brain activity (oxygenated hemoglobin concentration ([HbO2]), deoxygenated hemoglobin concentration ([HHb]), oxygenation difference hemoglobin concentration changes (HbOxy = HbO2 – HHb), total hemoglobin (HbTotal = HbO2 + HHb)) were measured in thirty-three young adults (age = 23.12 ± 3.86 years, mean ± SD) during three conditions: in a postural task, quiet standing (single motor task), quiet standing while performing a concurrent motor task - answer the smartphone (motor dual-task) and quiet standing while performing a concurrent cognitive task—arithmetic and memory tasks (cognitive dual-task). After data processing, the Wilcoxon signed-rank test was used for comparison.

Results
We found increased [HbO2] in young adults while performing cognitive dual-task compared to the single motor task and motor dual-task (P &lt; 0.05). HbOxy differences between cognitive and motor dual-task were found (P &lt; 0.05). No significant differences between single and motor dual-task in [HbO2] were observed.

Conclusions
Hemodynamic activity in the prefrontal cortex was significantly increased in cognitive dual-task compared to the single motor task. Pre-frontal hemodynamics appear not to be influenced by the number of motor tasks performed while the opposite occurs for the cognitive ones which may arise because the demand in the prefrontal cortex is greater in cognitive tasks while during the motor tasks the [HbO2] is recruited elsewhere.
Quality of life of students in polytechnic higher education at the Santarem and Leiria: the impact of COVID-19
Authors: Figueiredo Maria do Carmo , Amendoeira José , Rosa Marta , Matos Rui , Silva Mário , Gonzaga Luís 
Published: August 2021

Abstract

Background
The epidemic of COVID-19 caused by the Coronavirus -SARS-CoV-2, was declared by the World Health Organization an International Public Health Emergency. The 2019–2020 coronavirus pandemic has affected educational systems worldwide, leading to the closure of educational institutions. This situation kept students socially distant, with little adaptation time, interfering with their quality of life.

Methods
The aim of this study is to evaluate the quality of life of higher education students in the face of the impact of the COVID-19 pandemic. 775 students were selected by convenience sampling. Study with a quantitative, descriptive, correlational approach. The WHOQOL-bref instrument adapted from WHO was applied. Data analysis was undertaken using the IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY: IBM Corp.

Results
Students' self-assessment about Quality of Life is globally superior to the self-assessment with their satisfaction with health, where the female students have lower average values than the male students. The WHOQOL-bref domains referring to Quality of Life with higher values were the Physical and the Environment ones, with the Social Relations and Psychological domains having the lowest values.

Conclusions
The development of this study made it possible to achieve the objective set. The domain of social relations has low average values, with students from IPSantarem standing out, with lower self-assessment of QoL in this domain, compared to those from IPLeiria. In the psychological domain, the low average values in both institutes stand out, especially in IPLeiria, where the average is less than 50%, in both genders.
High-risk HPV genotypes and cervical lesions association in postmenopausal women
Authors: da Costa Ana Rita Fernandes Miranda , Sousa Cláudia , Isidoro Erica , Silva Regina , Mourato Cristiana 
Published: August 2021

Abstract

Background
Persistent infection by high-risk Human Papillomavirus (hrHPV) are the major cause of cervical cancer. Studies report disparities in the incidence of infection and the various genotypes of this virus in different age groups, suggesting a higher frequency of hrHPV in young women and low-risk subtypes being predominant in older women. This study aimed to investigate the incidence and distribution of hrHPV genotypes in postmenopausal women as well as the correlation with the cytological findings.

Methods
16 859 women, aged 50–64 years, performed cervical cancer screening test in Friuri Venezia Giulia region, Italy. The infection was evaluated by the Polymerase Chain Reaction methodology and the positive samples were evaluated by Liquid Based Cytology according to the Bethesda System from 2014. A statistical analysis was performed to study the molecular and cytological data of this population.

Results
hrHPV infection were found in 5.8% of the women and 78.3% of these were caused by hrHPV other than HPV16 and HPV18 (). Also, 65.7% of the positive samples were negative for intraepithelial lesion or malignancy while low grade squamous intraepithelial lesion was the most frequent (22.4%). There was an increase in the number of high-grade intraepithelial lesions in the presence of HPV16 compared to that recorded when this genotype was absent (20.8% vs. 8.5%). No cervical cancers were detected.

Conclusions
Infection with hrHPV is uncommon in postmenopausal women and it is mostly caused by subtypes less associated with the development of cervical cancer. Yet, HPV16 infection triggers the development of high-grade lesions.
Stay close to urban green spaces: current evidence on cultural ecosystem services provision
Authors: Vidal Diogo Guedes , Teixeira Catarina Patoilo , Dias Ricardo Cunha , Fernandes Cláudia Oliveira , Filho Walter Leal , Barros Nelson , Maia Rui Leandro 
Published: August 2021

Abstract

Background
Research suggests that access to urban green spaces (UGS) is crucial to support public and environmental health through ecosystem services (ES) provision. However, Cultural ecosystem services (CES), due to their connections to human emotion, a deep meaning, fulfilment, and motivation, have been less studied. CES provision in UGS are central to well-being, contributing to improving mental and physical health outcomes, as well as enhancing social cohesion. Accordingly, this systematic review aims to contribute to a better understanding of CES provision by UGS.

Methods
A systematic review was carried out in ScienceDirect (Article type = Research articles, years = 2000–2020), PubMed (Article type = journal article, text availability = Full text, year = 2000–2020) and Google Scholar (year = 2000–2020) databases. The keywords used in the search were: ‘urban green space’ OR ‘parks’ AND ‘cultural ecosystem service’ OR ‘cultural services’.

Results
The search returned 5417 results. After the screening process, 41 articles were reviewed. CES are mainly studied in Europe in the fields of social sciences and landscape management, linking human well-being, urban landscape management, and planning. The dimensions studied are (i) perception and assessment, (ii) recreation and mental and physical health, (iii) aesthetic appreciation/inspiration for culture, art, and design, (iv) tourism, and (v) spiritual experience and sense of place.

Conclusions
The study points out to the need for efforts to develop relational approaches to help understand what UGS users feel and experience. In particular, how UGS contribute towards promoting healthier and sustainable cities, and to fostering the well-being of people of all ages.
Universal API for wellness and fitness BLE sensors
Authors: Ferreira Emanuel , Roseiro Luís , Páris César 
Published: August 2021

Abstract

Background
A number of Bluetooth wellness and fitness devices were analysed to explore ways to access their raw data, using Bluetooth and the Generic Attribute Profile specification, while developing a Rest API using the .Net Core framework to provide a way to easily access said data in real time, in order to provide it to other uses, like dashboards or data science applications.

Methods
Two Bluetooth Low Energy devices were chosen for this experiment for their ability to record and transmit heart rate data in real-time, and as such our primary focus during development would be in obtaining this raw data. After collecting all the services and characteristics of the device, a method was implemented to read a value from a particular characteristic uuid, in our case the heart rate measurement. The resulting values obtained from the API follows the format specified in the corresponding XML file of the Bluetooth-SIG specification.

Results
The developed API worked as expected and provided useful information to advance its development to cover more devices, services, and features. We were able to obtain data not only from Heart Rate Monitoring, but also from the Battery Service and Device Information.

Conclusions
With these results it will be possible to expand the compatibility of the API to other devices, and also to other services present on the devices analysed, which were not considered in this preliminary analysis. The ultimate goal is the integration of this API on a rehabilitation oriented device being developed for this project.
Nanomaterials for magnetic hyperthermia
Authors: Graça Manuel Pedro , Soreto Silvia , Gavinho Silvia , Valente Manuel , Salgueiro Cristiane , Nunes José , Soares Paula , Lança Maria , Vieira Tania , Silva Jorge , Borges João 
Published: August 2021

Abstract

Background
Cancer remains as one of the major causes of mortality worldwide. Recent advances in nanoparticles based therapy mark a new era on cancer treatment. Many groups have investigated biological/physical effects of nanoparticles on tumour cells and how these vary with physical parameters such as particle size, shape, concentration and distribution. Magnetic hyperthermia (MHT) can be an alternative or an add-value therapy with demonstrated effectiveness. MHT uses magnetic nanoparticles, which can be directly applied to the tumour, where, by applying an external ac magnetic field, will promote a localized temperature increment that can be controlled.

Methods
LiFe5O8 nanocrystallites were synthesized by a novel and eco-friendly sol-gel process, using powder coconut water (PCW) has a mediated reaction medium. The dried powders were heat-treated between 400 and 1000 °C, being analysed their structure, morphology and magnetic properties; cytotoxicity and magnetic hyperthermia assays were performed.

Results
The heat-treated LiFe5O8 powder led to crystallite sizes from 50 nm to 200 nm. Increasing the temperature of the heat treatment, secondary phases tend to disappear. The cytotoxicity results revealed a non-cytotoxicity property, for concentrations below 5 mg/mL. The sample HT at 1000 °C, revealed hysteresis and magnetic saturation of 73 emu.g−1 at 300 K and a specific absorption rate(SAR) of about 80 W/g.

Conclusions
It was possible to synthesize LiFe5O8 by a novel, eco-friendly and sustainable route. The nanoparticles have a high heat efficiency, especially the sample heat-treated at 1000 °C, with SAR values similar to Fe3O4, showing potential to be used in the treatment of cancer, by MHT.
LDHA and CPT2 association with therapy resistance in prostate cancer
Authors: Vieira F Q , Cardoso A R , Gigliano D , Carneiro I , Henrique R , Jerónimo C , Silva R A 
Published: August 2021

Abstract

Background
The aerobic glycolysis as energy source in cancer confers a selective advantage for its proliferation and survival. Previous in vitro studies demonstrated that treatment with [C16Pyr][Amp], a potential anti-cancer drug in prostate, decreased the transcript levels of LDHA and CPT2, both involved in metabolic plasticity. In fact, LDHA and CPT2 were reported to be overexpressed in cancer, with association with poor prognosis and resistance to chemo- and radiotherapy. Since LDHA and CPT2 can be potential therapy resistance biomarkers, the aim of this work was to assess LDHA and CPT2 expression using PCa tissues.

Methods
LDHA and CPT2 expression was evaluated by immunohistochemistry in 57 PCa tissues, 24 from patients that developed resistance to hormonal therapy and 33 without therapy resistance. For both proteins, percentage of positive tumor cells, intensity of immunostaining, and immunoexpression pattern was determined by a blinded manner. Comparisons between therapy variables and protein expression were assessed using the Chi square test. P &lt; 0.05 indicated a statistically significant difference.

Results
LDHA expression is significantly associated with therapy resistance (P &lt; 0.001). Moreover, CPT2 pattern’s immunoexpression is also associated with therapy resistant (P &lt; 0.001), being cytoplasmatic expression most frequent in patients that respond to therapy (41%), whereas both nuclear and cytoplasmatic expression is more prevalent in therapy-resistant cases (48%).

Conclusions
LDHA overexpression is significantly associated with therapy resistance in PCa cases, while CPT2 cell expression distribution might be a predictive marker.
Correlation between endocrine function, inflammation, body composition, cardiorespiratory and muscular function in coronary patients
Authors: Gonçalves Catarina , Bravo Jorge , Abreu Ana , Raimundo Armando 
Published: August 2021

Abstract

Background
Cardiovascular diseases (CVD) are among the most prevalent illnesses worldwide, causing substantial mortality, morbidity and hospitalization. Understanding the correlation of thyroid function and glycemic metabolism and inflammation to body composition and cardiorespiratory and muscular function is imperative. This manuscript's main goal is to evaluate the association of thyroid function and glycemic metabolism to body mass composition and cardiovascular fitness (CRF) and muscular function in a group of coronary artery disease (CAD) patients.

Methods
To examine cross-sectional associations of thyroid function, glycemia, hemoglobin A1c (HgA1c) and C-reactive protein (CRP) with CRF, muscular function and body mass composition. Forty-five stable CAD patients were enrolled (aged 54.9 ± 10.0 years). Participants were assessed for body composition (DXA®), muscle strength (Biodex®), cardiorespiratory fitness (6-minute walking test) and blood biomarkers, including [CRP, Tyrode Hormones higher free thyroxine (FT4), lower total triiodothyronine (FT3) and metabolic parameters]. The Pearson correlation and t-test statistical measures were used for associations between thyroid function, glycemia, insulin, HgA1c and CRF/muscle strength, body composition.

Results
We found significant inter-correlations between body fat and FT4 (P &lt; 0.01), HgA1c (P = 0.01), insulin (P = 0.01) and blood glucose (P = 0.05); lean mass and FT3 (P = 0.001); and a negative inter-correlation between C-reactive protein and knee extensor and flexor isokinetic peak torques (P &lt; 0.01), and cardiorespiratory fitness (P &lt; 0.05).

Conclusions
Our findings showed that THs function and body mass fat, HgA1c, blood glucose, insulin and CRP were associated with the CRF, muscle strength or body composition. These results highlight the importance of endocrine and metabolic mechanisms concerning CRF and muscle strength in a group of patients with CAD.
Family caregiver support—a facilitator to empower family caregivers
Authors: Fernandes Sílvia , Portugal Paula , Mullins Lhara , Power Martin , Letica-Crepulja Marina , Stevanović Aleksandra , Frančišković Tanja , Silva Regina A 
Published: August 2021

Abstract

Background
Mental disorders are highly prevalent, placing an enormous burden on individuals, society and economy. Research shows that family members who provide care to individuals with chronic or disabling mental conditions are themselves at risk. As a response to this problem, the project ‘Family Caregiver Support - Strategies and tools to promote the mental and emotional health of caregivers’ emerged, funded by Erasmus + Program and carried out by 8 European partners including ESS|P.PORTO.

Objectives
To empower family members as caregivers and to give them access to relevant medical information and to psychological support for their own needs.

Methods
A Guide and a Resource Pack concerning 9 important mental health disorders were developed. An interactive e-platform and a mobile App were developed to make available these materials. Validation of the products was carried out, in each country, by caregivers and health/social care professionals through online questionnaires. Data were collected and processed in an anonymous manner, and the confidentiality was ensured.

Results
In Portugal, 98% of respondents (25 caregivers/citizens interested on subject, and 25 health/social care professionals), consider the accessibility and attractivity of the platform very good or excellent; and more than 90% consider materials very effective for the caregiver’s empowerment. Some issues were identified to add to Resource Pack.

Conclusions
Data from partners is being processed but there is already strong evidence of the usability and efficacy of the project’s outcome, and a strong contribution was done for adult education concerning physical, mental and emotional health promotion of family caregivers.
Fetal MRI vs. fetal ultrasound in the diagnosis of pathologies of the central nervous system
Authors: Pimentel Inês , Costa João , Tavares Óscar 
Published: August 2021

Abstract

Background
Malformations of the central nervous system (CNS) constitute the 2nd most common group of fetal pathologies, which can be reflected throughout the patient's life. Fetal ultrasound (US), together with fetal magnetic resonance imaging (MRI) are extremely important techniques for the diagnosis of CNS malformations. The objective of this work was to address fetal US and fetal MRI, as well as the benefits of its use in different CNS pathologies and to ascertain which of the techniques presents better results.

Methods
For this systematic literature review, a search was conducted using databases such as PubMed® and ScienceDirect®, Google Scholar, b-on digital library, in a 10-year period, 2010 to 2020. 60 references were used, which met the inclusion criteria, namely compliance with the defined timeframe and the theme of the work to be addressed.

Results
As for the results, fetal US is the first-line technique for fetal evaluation, and its objective is to detect possible fetal malformations early, while fetal MRI complements the information collected through fetal US. When there are cases of isolated ventriculomegaly and complete agenesis of the corpus callosum, fetal US can correctly assess the pathology. When it comes to pathologies such as dysgenesis of the corpus callosum and malformations of the posterior fossa, fetal MRI evaluates more effectively in comparison to fetal US.

Conclusions
In conclusions, to reduce the number of false positives, the techniques should be used together, thus providing a better diagnosis.