bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noma: Penyakit Tropis yang Terabaikan
Authors: Reksodiputro Mirta Hediyati , Yosia Mikhael 
Published: July 2021

Abstract Noma is an orofacial gangrene often manifesting in malnourished children in developing and tropical countries. Epidemiological data on Noma are hard to find, but it is estimated that the global incidence of noma is 30-40,000 cases per year, with estimated mortality rate of about 85%. The cause of noma is multifactorial, but is often found in conjunction with malnutrition and with other diseases such as measles, malaria, and the human immunodeficiency virus (HIV) followed by poor oral hygiene. The pathogenesis of noma includes a rapidly spreading noninfectious gangrene infection of the face, often preceded by acute necrotizing gingivitis, and stomatitis. Microbiological studies show opportunistic infections caused by imbalance of normal intraoral microorganisms. The key to prevention is to increase food security, improve vaccination program against measles, prevention of malaria and HIV, and early detection and treatment of necrotic gingivitis and stomatitis. Early treatment with antibiotics can prevent gangrene or reduce the extent of the lesions. Late treatment consists of surgical rehabilitation, which is often hard to conduct. Access to medical care are usually very limited for noma patients due to their dire socioeconomic conditions who are often located in remote rural areas. Abstrak Noma adalah gangren orofasial yang menyerang anak-anak kekurangan gizi terutama di negara-negara berkembang dan negara-negara tropis. Data epidemiologi tentang noma sangat langka, tetapi perkiraan kejadian global saat ini adalah 30-40.000 kasus per tahun, dengan tingkat kematian sekitar 85%. Penyebab noma multifaktorial, namun sering ditemukan bersamaan dengan malnutrisi dan dengan penyakit lain seperti campak, malaria, dan human immunodeficiency virus(HIV). Seringpula keadaan berada bersamaan dengan kebersihan mulut yang buruk. Patogenesis noma meliputi infeksi gangren tidak menular yang menyebar cepat yang terjadi di wajah, sering didahului oleh gingivitis nekrosis akut, dan stomatitis. Studi mikrobiologi menunjukkan infeksi oportunistik yang disebabkan oleh ketidakseimbangan mikroorganisme intraoral normal. Pencegahan terletak pada ketahanan pangan, vaksinasi campak, pencegahan malaria dan HIV, termasuk deteksi dini dan pengobatan gingivitis nekrotis dan stomatitis. Pengobatan dini dengan antibiotik dapat mencegah gangren atau mengurangi luasnya lesi. Perawatan yang terlambat terdiri dari rehabilitasi bedah, yang seringkali rumit. Akan tetapi, akses ke perawatan medis sangat terbatas bagi pasien noma karena kondisi sosioekonomi mereka yang sangat memprihatinkan yang seringkali terletak di daerah pedesaan yang terpencil.
Reshaping of Shipping and Logistics in Smart, Green and Digital
Authors: Barata Fausta Ari 
Published: July 2021

The modern market has specific achievements as well as modern infrastructure. One of them is to build a smart port, environmentally friendly, and digitalization. Digitalization is part of industry 4.0, and both of them become a threat, but give opportunities to change the business and make a business model make a change. The international market has grown speedily sea transportation to become an important part on delivery goods from other countries. Sustainability sea transportation is done by providing easy access, affordability, safety, economist, reliability, infrastructure with the concept of environmentally friendly and friendly transportation service. Nowadays the maritime logistics is to become attention for stakeholders in the logistic sector. The evolution of maritime logistics is as a new discipline has produced greater change, from increasing ping ship, increasing customer request, the changing of a support role on supply chain, and logistic. The delivery with environmentally-friendly lead to use resources and energy to transport the people and good with a ship and special attention on decreasing resources and energy to preserving global environment and environmental pollutants resulted by ship.
Penerapan Data Mining untuk Klasifikasi Produk Merk Bata Menggunakan Algoritma K-Means
Authors: Samosir Hernita , Amin Muhammad , Harahap Indra Ramadona 
Published: July 2021

Abstract: Tanjungbalai Bata Store is a store that is engaged in the business of selling products and every day processes purchase data, sales data and transaction data. Transaction data is the result of sales that can be obtained so that store management knows the strategies that will be carried out to increase sales results. As for consumers who make transactions at stores for a separate reason, especially because of the completeness and many models that can be obtained from the Tanjungbalai brick shop, another reason is that the Tanjungbalai Brick Shop can provide a sense of comfort and peace in addition and the cleanliness seen from the store . There are many types of products sold at the Tanjungbalai Brick Shop. However, Tanjungbalai Brick Shop cannot classify products that are selling well and those that are not selling well. So that the difficulties experienced are the frequent shortage of stock of products that sell well because sales are high and the accumulation of products that are not selling well in the warehouse because the sellers are low. Based on the problems above, data mining is needed to classify which products are in demand and which are not. Data mining and k-means methods can help in this research combined with the PHP programming language and MySQL database. Keywords:Data Mining; Product Classification; K-Means Algorithm. Abstrak:Toko Bata Tanjungbalai adalah toko yang bergerak di bidang bisnis penjulalan produk dan setiap harinya melalukan proses data pembelian, data penjualan maupun data transaksi. Data transaksi merupakan hasil penjualan yang di dapat agar manajemen toko mengetahui strategi yang akan di lakukan untuk meningkatkan hasil penjualan. Adapun konsumen yang melakukan transaksi di toko memiliki alas an tersendiri ataupun di karenakan kelengkapan dan banyak model yang bisa di dapatkan dari toko bata tanjungbalai, alasan yang lain adalah Toko Bata Tanjungbalai dapat memberikan rasa nyamandan tentram di tambah lagi keramahan dan kebersihan yang di lihat dari toko tersebut. Ada banyak jenis produk yang terjual di Toko Bata Tanjungbalai, namun toko bata Tanjungbalai tidaklah mampu dalam membagikan kelompok produk tersebut masuk kategori laris dan tidak laris. Sehingga kesulitan yang dialami yaitu seringnya kekurangan stok produk yang laku karena penjualannya tinggi dan menumpuknya produk yang tidak laris di gudang karena penjualnnya rendah. Berdasarkan permasalahan di atas maka dibutuhkan data mining untuk mengelompokkan produk mana saja yang laris dan tidak. Data mining dan metode k-meansdapat membantu dalam penelitian ini dipadukan dengan pemrograman PHP dan MySQL. Kata Kunci :Data Mining; Klasifikasi Produk; Algoritma K-Means.
Perancangan Sistem Pelaporan Tindak Kekerasan Pada Perempuan dan Anak Di DP3A Kota Tanjungbalai
Authors: Lestari Oni Dewi , Saputra Herman , Rahayu Elly 
Published: July 2021

Abstract : At this time there are still many victims of violence who do not want to report the violence they have experienced because they do not want their identities to be known by others, because it will tarnish their self-respect and because of the complicated reporting mechanism, where the reporter who is going to make a report must come directly. So it is made how to design a violence reporting system and implement PHP and MySQL in it. The methodology used in this research is to first identify problems, study literature, collect data, analyze data, design systems, test systems and implement systems. This violence reporting system can make it easier for reporters to report violence without having to come to the office and it can be concluded that the research has been able to create a reporting system for violence against women and children in DP3A and PMK Tanjungbalai City by implementing the PHP programming language and database MySQL.Keyword : Reporting System, PHP dan MySQL, Violence, DP3A and PMK Abstrak : Pada saat ini masih banyak korban kekerasan yang tidak ingin untuk melapor kekerasan yang dialaminya karena tidak ingin identitasnya diketahui orang lain, karena akan mencoreng harga dirinya dank arena mekanisme pelaporan yang rumit, dimana pelapor yang akan membuat laporan harus datang langsung. Sehingga dibuat bagaimana merancang sistem pelaporan tindak kekerasan dan menerapkan PHP dan MySQL didalamnya. Metodologi yang digunakan pada penelitian ini adalah terlebih dahulu melakukan identifikasi masalah, studi literature, pengumpulan data, analisis data, perancangan sistem, pengujian sistem dan implementasi sistem. Sistem pelaporan tindak kekerasan ini dapat mempermudah para pelapor dalam melakukan pelaporan tindak kekerasan tanpa harus datang ke kantor dan telah dapat disimpulkan bahwa penelitian telah mampu membuat sebuah sistem pelaporan tindak kekerasan pada perempuan dan anak di DP3A dan PMK Kota Tanjungbalai dengan menerapkan bahasa pemrograman PHP dan database MySQL. Kata Kunci : Sistem Pelaporan, PHP dan MySQL, Tindak Kekerasan, DP3A dan PMK
Caracterización del modelo de implantación urbana y ocupación del territorio de la antigua Zona del Canal. Caso de estudio Fuerte Clayton
Authors: Arosemena Graciela , Alba Almyr , Stapf María , Carceller Xavier 
Published: July 2021

Este estudio tiene como objetivo comprender la influencia del urbanismo norteamericano en la Zona del Canal, determinar qué procesos de urbanización se dieron y las implicaciones ello tuvo en la salud humana, los recursos naturales y la biodiversidad, a través del caso del Fuerte Clayton. Para ello se identifica la influencia que tuvo el urbanismo higienista norteamericano del siglo XIX sobre el modelo de implantación urbana de la Zona del Canal, e identificar los elementos en común. Y cómo las estrategias de control de las enfermedades transmitidas por los mosquitos se reflejaron en el urbanismo y en el impacto sobre el territorio.
El estudio se basa en la valoración ambiental del Fuerte Clayton, determinado por los dos aspectos fundamentales que definen el impacto ambiental de un asentamiento urbano. El primero la idoneidad de la localización del sitio, y el segundo la estructura urbanística del modelo ciudad que se adopta.
Concluyendo que la localización del Fuerte Clayton desde el punto de vista ambiental y sanitario no fue idóneo, y las tareas continuas de control territorial de los criaderos de mosquito a lo largo del tiempo lo evidencian. De forma que la matriz ecológica del territorio fue alterada con el fin de remediar una ubicación improcedente. Por otro lado la adaptación del trazado urbano a la topografía y el uso sistematizado de drenajes en los poblados y fuertes de la Zona del Canal, fue una práctica usual, con evidentes referencias a los postulados sanitarios del urbanismo del siglo XIX.
PENINGKATAN KETERAMPILAN MEMBACA PEMAHAMAN MELALUI METODE HYPERSCAN PADA SISWA SMA MUHAMMADIYAH 2 PALEMBANG
Authors: Mulyati Mulyati 
Published: July 2021

The hyper-scan method is one way that instructors employ to help students in class XI improve their reading comprehension. Indeed, many students struggle with reading comprehension. This is a Classroom Action Research (CAR) research comprising two cycles of 4 stages: planning, action, observation, and reflection. was used to analyze the test data. The result shows the average pre-cycle score was 63.83, the first cycle score was 73.77, and the second cycle score was 84.33. According to the percentage of students who qualify, there has traditionally been an increase. The percentage of completion in pre-cycle tests ranged from 10% to 46.6 percent in the first cycle and up to 90% in the second cycle. As a result, it can be concluded that the hyper-scan method can assist in reading comprehension skills development
Citra Diri Pada Perempuan Berhijab Pengguna Rokok Elektrik
Authors: Mawardah Mutia , Darma Imam Budi 
Published: July 2021

Abstract : This study aims to look at the self-image of female adolescents wearing e-cigarette wearing hijab. What factors affect the self-image of women who use e-cigarette wearing hijab, as well as how the self-image of women wearing e-cigarette wearing hijabs. This study uses a qualitative research design and uses a phenomenological approach to be able to see the self-image of women who use e-cigarettes. In this study, researchers used 6 sources. 2 people as research subjects, 2 people as the perpetrator informant and 2 informants know of each subject. The results of this study found that the self-image of the e-cigarette wearing hijab woman who has a self-image that is not much different. The first subject has four self-images, while the second subject also has four self-images from four self-image images. Each description that is owned by the subject is also based on several factors, namely physical condition, family condition, seeking attention, depending on smoking and expectations.

Keywords: Self Image, Electric Cigarette, Female Wearing Hijab

Abstrak : Penelitian ini bertujuan untuk mengetahui citra diri remaja perempuan berhijab pengguna aktif rokok elektrik. Faktor apa saja yang mempengaruhi citra diri perempuan berhijab pengguna rokok elektrik, serta bagaimana gambaran citra diri perempuan berhijab pengguna rokok elektrik. Penelitian ini menggunakan desain penelitian kualitatif serta menggunakan pendekatan fenomenologi untuk dapat mengetahui citra diri perempuan berhijab pengguna rokok elektrik. Dalam penelitian ini, peneliti menggunakan 6 sumber. 2 orang sebagai subjek penelitian, 2 orang sebagai informan pelaku dan 2 orang informan tahu dari masing-masing subjek. Hasil penelitian ini menemukan bahwa citra diri perempuan berhijab pengguna rokok elektrik memiliki citra diri yang tidak jauh berbeda. Subjek pertama memiliki empat citra diri, sementara subjek kedua juga memiliki empat citra diri dari empat gambaran citra diri. Setiap gambaran yang dimiliki oleh subjek juga dipengaruhi oleh beberapa faktor yaitu keadaan fisik, teman sebaya dan kelompok, keadaan keluarga, mencari perhatian, ketergantungan merokok dan harapan.

Kata kunci: Citra Diri, Rokok Elektrik, Wanita Berhijab
Developing Two Rapid Protein Extraction Methods Using Focused-Ultrasonication and Zirconia-Silica Beads for Filamentous Fungi Identification by MALDI-TOF MS
Authors: Ning Ya-Ting , Yang Wen-Hang , Zhang Wei , Xiao Meng , Wang Yao , Zhang Jing-Jia , Zhang Ge , Duan Si-Meng , Dong Ai-Ying , Guo Da-Wen , Zou Gui-Ling , Wen Hai-Nan , Guo Yan-Yan , Chen Li-Ping , Chai Miao , He Jing-Dong , Duan Qiong , Zhang Li-Xia , Zhang Li , Xu Ying-Chun 
Published: July 2021

Filamentous fungi identification by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been challenging due to the lack of simple and rapid protein extraction methods and insufficient species coverage in the database. In this study, we created two rapid protein extraction methods for filamentous fungi: a one-step zirconia-silica beads method (ZSB) and a focused-ultrasonication method (FUS). The identification accuracy of two methods were evaluated with the VITEK MS, as well as number of spectra peaks and signal-to-noise ratio (S/N) with M-Discover 100 MALDI-TOF MS compared to the routine method. The better method was applied to build a filamentous fungi in-house spectra library for the M-Discover 100 MS, and then another one and routine method were performed in parallel to verify the accuracy and commonality of the in-house library. Using the two optimized methods, the dedicated operating time before MALDI-TOF MS analysis was reduced from 30 min to 7 (ZSB) or 5 (FUS) min per sample, with only a few seconds added for each additional strain. And both two methods identified isolates from most mold types equal to or better than the routine method, and the total correct identification rate using VITEK MS was 79.67, 76.42, and 76.42%, respectively. On the other hand, the two rapid methods generally achieved higher maximum and minimum S/N ratios with these isolates tested as compared to the routine method. Besides, the ZSB method produced overall mean of maximum and minimum S/N ratio higher than that by FUS. An in-house library of M-Discover MS was successfully built from 135 isolates from 42 species belonging to 18 genera using the ZSB method. Analysis of 467 isolates resulted in 97.22% correctly identified isolates to the species level by the ZSB method versus 95.50% by the routine method. The two novel methods are time- and cost-effective and allow efficient identification of filamentous fungi while providing a simplified procedure to build an in-house library. Thus, more clinical laboratories may consider adopting MALDI-TOF MS for filamentous fungi identification in the future.
Uterine Development During Induced Puberty in Girls with Turner Syndrome
Authors: Obara-Moszynska Monika , Dzialach Lukasz , Rabska-Pietrzak Barbara , Niedziela Marek , Kapczuk Karina 
Published: July 2021

ObjectiveMost girls and women with Turner syndrome (TS) require estrogen replacement therapy (ERT) to initiate or maintain pubertal development. Most likely, the most fundamental effect of ERT in hypogonadism is the promotion of uterine growth. The optimal ERT model is still being discussed. The present study aimed to assess uterine size in girls with TS in the prepubertal state during and after the induction of puberty and compare it to a healthy population.MethodsThe analysis encompassed 40 TS girls. The prepubertal and postpubertal control groups contained 20 healthy girls each. All patients with TS were treated with 17-ß estradiol. Uterine imaging was performed with two-dimensional (2D) transabdominal ultrasound. The uterine volume (UV) and fundocervical antero-posterior ratio (FCR) were calculated in patients with TS before the pubertal induction, after 6-12 months of estrogen replacement therapy (ERT), after ≥ 36 months of ERT or ≥ 12 months after menarche.ResultsThe average age of TS patients at estrogen introduction and at the last control visit, when the uterus was considered mature, was 12.9 years and 16.1 years, respectively. The UV in patients with TS at the beginning of ERT was 1.55 ± 1.22 cm3 and was not significantly different from the UV in the prepubertal controls. The mature UV in patients with TS was 31.04 ± 11.78 cm3 and was significantly smaller than the UV of the postpubertal controls (45.68 ± 12.51 cm3, p&lt;0.001). The FCR in girls with TS did not differ significantly from that in the prepubertal and postpubertal control groups, respectively. No prognostic factors could be established for the final UV. By the last control visit, thelarche had advanced in most patients to Tanner 4 and 5 (37.5% and 40%, respectively).ConclusionsBefore the onset of ERT, patients with TS have a uterus similar in size to that in prepubertal healthy girls. Pubertal induction in patients with TS causes a significant increase in the UV that is detectable after 6-12 months of ERT. The mature uterus is smaller in patients with TS than in the age-matched healthy population.
The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjögren’s Syndrome
Authors: Verstappen Gwenny M. , Gao Lu , Pringle Sarah , Haacke Erlin A. , van der Vegt Bert , Liefers Silvia C. , Patel Vishal , Hu Yanhua , Mukherjee Sumanta , Carman Julie , Menard Laurence C. , Spijkervet Frederik K. L. , Vissink Arjan , Bootsma Hendrika , Kroese Frans G. M. 
Published: July 2021

BackgroundWhile all salivary glands (SGs) can be involved in primary Sjögren’s syndrome (pSS), their respective role in pathogenesis remains unclear. Our objective was to assess immunopathway activation in paired parotid and labial gland tissue from biopsy-positive and biopsy-negative pSS and non-SS sicca patients.MethodsParaffin-embedded, paired parotid and labial salivary gland tissue and peripheral blood mononuclear cells were obtained from 39 pSS and 20 non-SS sicca patients. RNA was extracted, complementary DNA libraries were prepared and sequenced. For analysis of differentially expressed genes (DEGs), patients were subdivided based on fulfillment of ACR-EULAR criteria and histopathology.ResultsWith principal component analysis, only biopsy-positive pSS could be separated from non-SS sicca patients based on SG gene expression. When comparing the transcriptome of biopsy-positive pSS and biopsy-negative non-SS sicca patients, 1235 and 624 DEGs (FDR&lt;0.05, log2FC&lt;-1 or &gt;1) were identified for parotid and labial glands, respectively. The number of DEGs between biopsy-negative pSS and non-SS sicca patients was scarce. Overall, transcript expression levels correlated strongly between parotid and labial glands (R2 = 0.86, p-value&lt;0.0001). Gene signatures present in both glands of biopsy-positive pSS patients included IFN-α signaling, IL-12/IL-18 signaling, CD3/CD28 T-cell activation, CD40 signaling in B-cells, DN2 B-cells, and FcRL4+ B-cells. Signature scores varied considerably amongst pSS patients.ConclusionTranscriptomes of paired major and minor SGs in pSS were overall comparable, although significant inter-individual heterogeneity in immunopathway activation existed. The SG transcriptome of biopsy-negative pSS was indistinguishable from non-SS sicca patients. Different patterns of SG immunopathway activation in pSS argue for personalized treatment approaches.