bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Bowel inflammation to the Bone and Joints: Rheumatologic examination in Inflammatory Bowel Disease (IBD)
Authors: Tavassoli Samane , Mirkamali Seyed Farzam , Shahabinasab Iman , Norouzi Alireza , Amiriani Taghi , Abdolahi Nafiseh , Livani Somayeh , Mirkarimi Honey Sadat , Besharat Sima , Amlashi Fazel Isapanah 
Published: March 2021

Abstract
Background: The most common complications in inflammatory Bowel Disease (IBD) are musculoskeletal manifestations that are reported in more than 50% of patients. Objectives: In this study, we aimed to evaluate the musculoskeletal and radiologic manifestations in our IBD patients.Methods: In this study on 96 mild-to-moderate IBD patients (76 UC, 18 CD and 2 undifferentiated IBD) with mean (SD) age of 39.28 (11.42) years, 44 (45.8%) were males and 52 were (54.2%) females. Patients were examined by an expert rheumatologist and their musculoskeletal symptoms were assessed. The musculoskeletal system was evaluated by Modified Schober test, Thoracic expansion (TE), Occiput to wall distance (OWD), and Patrick's or FABER test. Peripheral joints were also examined in all four extremities. Then patients were referred for pelvic and lumbosacral x-ray. Sacroiliitis grading was performed using the New York criteria. Results: Inflammatory low back pain was reported in 5 (5.2%), enthesopathy in 6 (6.5%) and dactilitis in 1 (1.1%). Positive Schober test was recorded in 5 (5.2%) and Patrick test in 3 (3.1%). Forty-nine (51%) cases had normal imaging with no sacroilliitis, endplate sclerosis was seen in 33 cases (34.4%), grade 3 and grade 4 were seen in 10 cases (10.4%). Conclusions: In the present study, 34.4% of the IBD patients had mild radiologic changes as endplate sclerosis and 95% had a normal physical examination.
Co-W Bimetallic Carbides as Sulfur Host for High-Performance Lithium–Sulfur Batteries
Authors: Zhang Dongke , Huang Ting , Zhao Pengfei , Zhang Ze , Qi Xingtao , Yang Zhenyu , Cai Jianxin 
Published: March 2021

Abstract
Due to the low conductivity of sulfur and the dissolution of polysulfides, the research and application of lithium-sulfur (Li-S) batteries have encountered certain resistance. Increasing conductivity and introducing polarity into the sulfur host can effectively overcome these long-standing problems. Herein, We first prepared Co3W3C@ C@ CNTs / S material and used it in the cathode of lithium-sulfur batteries, The existence of carboxylated CNTs can form a conductive network, accelerate the transmission of electrons and improve the rate performance, and polar Co3W3C can form a strong interaction with polysulfide intermediates, effectively inhibiting its shuttle effect, improving the utilization of sulfur cathode electrodes, and improving the capacity and cycle stability. The Co3W3C@C@CNTs / S electrode material has a capacity of 1,093 mA h g-1 at a 0.1 A g− 1 and 482 mA h g-1 at 5 A g− 1. Even after 500 cycles of 2 A g− 1, the capacity of each cycle is only reduced by 0.08%. The excellent stability of this material can provide a new idea for the future development of lithium-sulfur batteries.
A technique for repairing rotator cuff transtendinous tears with a remnant attached to the footprint
Authors: Choi Hyung-Suk , Lee Byung-Ill , Kim Jae-Hyung , Cho Hyung-Ki , Seo Gi-Won 
Published: March 2021

Abstract
Background

Some unusual rotator cuff (RC) tears are located in more proximal tendinous portions, with substantial remnant tissue attached to the footprint. The two options for surgical repair are sacrificing or preserving the remnant tissue. We introduce a surgical repair technique that preserves as much of the remnant footprint as possible.
Surgical technique

: A double-loaded suture anchor is inserted into the subchondral bone at the medial portion of the RC footprint; the lateral remnant tissue is preserved. Each strand is shuttled and repassed through the medial portion of the tendon in a mattress fashion using a suture hook device. Then, multiple no. 1 PDS sutures are passed through the medial and lateral stumps and left untied. Strands from the suture anchor are first tied in a double mattress fashion. Then, the repair is completed by tying the remaining no. 1 PDS sutures.
Conclusions

We propose a remnant-preserving RC repair technique for transtendinous RC tears with sufficient tissue remaining within the RC footprint. This technique appears advantageous in terms of re-establishing an environment that promotes tendon healing after repair.
Women’s Sexual Experiences and Adjustment after Cervical Cancer Treatment in Tikur Anbessa Specialized Hospital, Addis Ababa- Ethiopia: A Qualitative Study
Authors: Habte Teshome , Yada Gashaw , Gemechu Endalew 
Published: March 2021

Abstract
Background: Cervical cancer is one of the most common cancers and the leading causes of cancer deaths globally. Objective: This study aimed to explore the experiences of women in sexual adjustment after treatment of cervical cancer at Tikur Anbesa Specialized hospital. Method: A descriptive phenomenological qualitative approach and semi-structured in-depth interview method were used and 14 clients recruited to collect data from 2nd February to 15th March 2019. The interviews were audio-taped and analyzed using the procedures of thematic content qualitative data analysis. Results: In this finding, four themes emerged for data analysis, namely, Treatment Side effect, Sexual Problems after radiation therapy, Knowledge deficit, and poor coping strategies of sexual relationships which reflect women with cervical cancer treatment problems. Conclusion and Recommendations: This finding reveals that the Sexual life of women affected by physical changes brought by cancer therapy, information gaps, or knowledge deficit related to cervical cancer and pelvic radiotherapy. the researcher recommended that there should be broad promotion including counseling service and integrated service set up to alleviate sexual related problems and treatment side effect for cervical cancer.
Effectiveness of the Internet-based Versus Face-to-Face Interaction on Reduction of Tobacco use among Adults: A Systematic Review and Meta-Analysis
Authors: Kumar Rajesh , Kant Ravi , Yadav Poonam , Rodney Tamar , Bairwa Mukesh 
Published: March 2021

Abstract
Literature reported the effectiveness of internet-based interventions over face-to-face interaction on tobacco quitting; however, limited sample size reinforces to integrate and analyze these studies' findings to reach a single conclusion. Therefore, we evaluated the effectiveness of the internet-based versus face-to-face interventions on reducing tobacco use with a systematic search through various electronic databases such as Medline, PsychInfo, PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ResearchGate, Google Scholar, and Academia. Reference lists of the eligible articles were also screened. Full-text articles were included as per eligibility criteria (PICO framework). A total of 13 studies were selected for meta-analysis, with 3852 and 3908 participants in intervention and control groups. Forest plot favours the intervention group at one month follow up for tobacco quitting (OR: 2.37, CI: 1.86–3.02, P-0.00001, I2 = 0%), at three months (OR: 1.88, CI: 1.48–2.40, P-0.00001, I2 = 42%) at six months (OR: 2.02, CI: 1.64–2.50, P-0.00001, I2 = 38%) and at 1 year of follow-up (OR: 1.43, CI: 1.18–1.74, P-0.00001, I2 = 36%). Internet and web-based interventions are highly useful in tobacco quitting at one month, three months, six months, and one year of follow-up compared to face-to-face interaction or no intervention, although the evidence level was moderate.Prospero Registration number- CRD42020214306
Droplet-vitrification methods for apical bud cryopreservation of yacon [Smallanthus sonchifolius (Poepp. and Endl.) H. Rob.]
Authors: Hammond Stacy Denise Hammond , Viehmannova Iva , Zamecnik Jiri , Panis Bart , Faltus Milos 
Published: March 2021

Abstract
This study aimed to develop a cryopreservation protocol for the long-term preservation of yacon [Smallanthus sonchifolius (Poepp. and Endl.)], an Andean crop with high fructooligosaccharide content in its tuberous roots. Initially, the cryopreservation protocol was developed using a yacon clone originated from Ecuador classified as ECU 41. Osmotic dehydration of apical buds (2–3 mm long) was carried out by assessing two plant vitrification solutions, PVS2 (15, 30, and 60 min) at 0°C and PVS3 (30, 45, 60, and 75 min) at 22°C. After cryopreservation, the apical buds were thawed and placed on MS medium ± 0.1 mg l− 1 N6-benzyladenine (BA). The survival rates ranged from 37 to 90% within all treatments, with those subjected to PVS2 and PVS3 for 60 min showing the highest survival rates on MS medium without BA (87 and 90%, respectively). At 12 weeks post cryopreservation, these treatments also provided the highest regrowth rates, both reaching 73% of normally growing (shooting, rooting) plantlets. Survival rates on MS + 0.1 mg l− 1 BA regrowth medium reached up to 90%; however, regrowth into normally rooted plantlets did not exceed 67% post cryopreservation. The optimized protocols were then applied to 4 additional yacon clones originated from Bolivia and Peru, classified as BOL 22, BOL 23, PER 12, and PER 14. This resulted in survival and regeneration rates ranging between 79.7–94.1% and 66.3–75.4% respectively. Our study shows that optimal cryopreservation protocols for the long-term conservation of yacon can be based on both PVS2 and PVS3 vitrification solutions.
Enhanced Recovery After Surgery (ERAS) Program for Elderly Patients With Long-level Lumbar Fusion
Authors: WANG PENG , KONG CHAO , TENG ZE , LI ZHONGEN , ZHANG SITAO , SUN WENZHI , Lu Shibao 
Published: March 2021

Abstract
Background: Currently, ERAS for spinal surgery field is still in its beginnings, the major protocol lessons learned from other surgical specialties and lack of ERAS program for elderly patients (>70 years old). Geriatric patients has its own special characteristics resulting in more harmed by surgical stress. The enhanced recovery after surgery (ERAS) are designed to improving recovery after surgery and can result in substantial benefits in both clinical outcomes and cost-effectiveness. In the present study, we aimed to determine whether enhanced recovery after surgery (ERAS) significantly improved satisfaction and outcomes in elderly patients (>70 years old) with long-level lumbar fusion. Methods: A total of 144 patients were included, 62 in the ERAS group and 82 case-matched patients in the non-ERAS group. Data including demographic, comorbidity and surgical information were collected from electronic medical records. ERAS interventions were categorised as preoperative, intraoperative and postoperative. We also evaluated primary outcome, surgical complication and length of stay (LOS).Results: There were no statistically significant intergroup differences in regards to demographics, comorbidities、American Society of Anaesthesiologists (ASA) grade、or the number of fusion levels. There were also no differences between mean surgery time of intraoperative blood loss between the ERAS and non-ERAS groups. In addition, the mean preoperative Visual Analogue Score (VAS) for the back and legs and Oswestry Disability Index (ODI) score were not significantly different between the two groups. Overall, ERAS pathway compliance was 91.5%. There were no significant differences in the mortality rates between the ERAS and non-ERAS groups. However, we observed a statistically significant decrease in the complications in the ERAS group(6 in the ERAS group versus 23 in the non-ERAS group, p=0.006) and LOS in the ERAS group (17.74±5.56 of ERAS group versus 22.13±12.21 in non-ERAS group, p=0.041). Multivariable linear regression showed that comorbidities (p=0.028) and implementation of ERAS program (p=0.002) were correlated with prolonged LOS. Multivariable logistic regression showed that comorbidities (p=0.029)， implementation of ERAS program (p=0.043) and preoperative VAS Back (p=0.046), were correlated with complications. Conclusions: This report describes the first ERAS protocol used in elderly patients after long-level lumbar fusion surgery. Our ERAS program is safe and could help decreases LOS and complication in elderly patients with long-level lumbar fusion.
Evaluation of Integrated Management of Acute Malnutrition (IMAM), POSHAN-II in Rajasthan, India: A Quasi-Experimental Study
Authors: Sivaraman Shobana , Gorla Ishank , Sharma Laxman , Mangal Daya Krishna , Gupta Shiv Dutt 
Published: March 2021

Abstract
Background According to National Family Health Survey (NFHS) the percentage of severely wasted children has increased from 6.4 percent (NFHS-3, 2005-06) to 7.5 percent (NFHS-4, 2015-16). In 2018, National Health Misison (NHM), Government of Rajasthan implemented Integrated Management of Acute Malnutrition (IMAM), POSHAN -II in 20 distrcts of Rajasthan. The research study is aimed to evaluate the effectiveness of IMAM POSHAN-II with respect to the percentage of cured, non-recovered and defaulted children and rate of weight gain. MethodsCommunity based quasi experimental pre post test research study was conducted among 1105 SAM children aged 6-59 months. The baseline study conducted during enrollement of SAM children, mid line and endline study was conducted after eight and twelve weeks of treatment. Socio demographic factors and nutritional status of children was collected from primary caregivers and sampled children of the study. Results After 8 weeks of treatment, the outcomes were 42.4 percent of cured cases, 4.1 percent of defaulters and 53.5 percent continued in the program. After 12 weeks of treatment, outcomes were – 66.9 percent of cured cases, 8.1 percent of defaulters and 25 percent of non-recovered cases. The mean rate of weight gain among cured cases at 8 weeks was 3.2 g/kg/day. Binary logistic regression model indicates that after 8 and 12 weeks of treatment, the odds of SAM children getting cured increases with increasing family income. Children of educated mothers were 6.3 times more likely to recover than children of mothers with no education. Compliance towards EDNS is significantly associated with recovery of children at 8 and 12 weeks. ConclusionThe IMAM POSHAN-II program being first of its kind to be implemented on large scale in India demonstrate a piece of evidence that SAM children without medical complications can be treated successfully at community and household level. The program deserves be integrated with the existing primary health system of the state. The program was successful with high level of political commitment and collobration with partner agencies for technical and financial assistance.
The Lived Experience of Internationally Recruited Nurses in Oman a Phenomenological Study
Authors: Ph Glenn Ford D. Valdez , MSN RM RN Arcalyd Rose R. Cayaban , PhD Muna B. Ajzoon , PhD Gina M. Molina , Ed.D RN Visitacion O. Bumalay 
Published: March 2021

Abstract
Aim: The study aimed at exploring the lived experience of internationally recruited nurses in Oman that seeks to know how culture affects their adjustment process. The study also explored the acculturation that nurses undertake to adapt to a new culture from a personal and nursing perspective and the study also identified the support mechanisms that are in place to assist in the transition.Methods: The study is a qualitative phenomenological study defined as an approach to understanding people’s everyday life experience utilizing Collaizi’s 9 Phenomenological Steps. The samples were taken from four (4) major governorates in Oman namely Dhofar, Dhak​liya​, ​ ​North Batinah & Muscat. Out of 45 Nurses, 18 met the inclusion criteria and volunteered to undergo the structured phone interviews and conferences. Data Analysis was performed using the analytical software NVivo ver 12.Results:18 nurses consented to participate in the interview, most Internationally recruited nurses holding a bachelor's degree with an average age of 33.5 years. Most participants reported challenges in their transition to Oman upon being deployed. The primary area of concern arose from not having a structured ethical recruitment system and orientation programs. Conclusion: There is a need for a more systematic and ethical recruitment strategy that enhances IRN’s full integration into the host country’s social, religious, and cultural system. It was also found that language is an integral part of the IRN’s assimilation therefore the need for a formal and structured training and orientation program must be in place in both recruiting agencies and the catchment facilities in Oman
World War II Effects on Prevalence and Pattern of Multimorbidity in Older Adults: Results From the KORA-Age Study
Authors: Arshadipour Ava , Thorand Barbara , Peters Annette , Linkohr Birgit , Rospleszcz Susanne , Heier Margit , Ladwig Karl-Heinz 
Published: March 2021

Abstract
While risk factors for age-related diseases may increase multimorbidity (MM), early life deprivation may also accelerate the development of chronic diseases and MM. This study explores the prevalence and pattern of MM in 65-71 year-olds individuals born before, during, and after World War II in Southern Germany based on two KORA (Cooperative Health Research in the Region of Augsburg) -Age studies. MM was defined as the presence of at least two chronic diseases, and birth periods were classified into five phases: pre-war, early war, late war, famine, and after the famine period. Logistic regression models were used to analyze the effect of the birth phases on MM with adjustment for sociodemographic and lifestyle risk factors. Furthermore, we used agglomerative hierarchical clustering to investigate the co-occurrence of diseases. Participants born during the late war phase had the highest prevalence of MM (62.2%) and single chronic diseases compared to participants born during the other phases. Being born in the late war phase was significantly associated with a higher odds of MM in older age (OR = 1.83, 95% CI: 1.15-2.91). In women, the prevalence of joint, gastrointestinal, eye diseases, and anxiety was higher, while in men, heart disease, stroke, and diabetes were more common. Moreover, three main chronic disease clusters responsible for the observed associations were identified: joint and psychosomatic, cardiometabolic and, internal organs diseases. Our results suggest that early life experiences may accelerate the development of MM. Moreover, the identification of disease clusters could assist in management strategies for diseases multimorbidities.
Methodological Challenges and Solution Strategies During Implementation of a Midwife-led Multicentre Randomized-controlled Trial (RCT) in Maternity Hospitals
Authors: Striebich Sabine , Mattern Elke , Oganowski Theresa , Schäfers Rainhild , Ayerle Gertrud M. 
Published: March 2021

Abstract
Background: RCTs with complex interventions are methodically challenging. Careful planning under everyday conditions in compliance with the relevant international quality standard (ICH-GCP guideline) is crucial. Specific challenges exist for RCTs conducted in delivery rooms due to various factors that cannot be planned beforehand, such as “peak hours” of births and a high work burden for midwives and obstetricians. Moreover, in Germany as well as in other countries, midwives and obstetricians have frequently little experience as investigators in clinical trials. Methods: The randomised controlled trial “BE-UP” tests the effectiveness of an alternative birthing room on the rate of vaginal births and woman-oriented outcomes. In the process of implementing the trial in 17 obstetrical units and in the endeavour to reach the calculated sample size of 3,800 women, the research team encountered a variety of unexpected challenges. The aim is to describe in greater detail the methodical and organisational challenges and to inform about the research team’s strategies to overcome them.Results:The results are presented in five sectors: 1) Selection of and support for cooperating hospitals: they are to be selected according to predefined criteria and strategies to offer continuous support in trial implementation must be mapped out.2) Establishing a process of requesting informed consent: a quality-assured process to inform pregnant women early on must be feasible and effective. 3) Individual, digital real time randomization: besides instructing the maternity teams appropriate measures for technical failure must be provided.4) The standardized birthing room: the complex intervention is to be implemented according to study protocol, yet adapted to the prevailing conditions in the delivery rooms.5) GCP-compliant documentation: midwives and obstetricians is to be instructed in high quality data collection, supported by external monitoring throughout the trial.Conclusion:Since not all potential challenges can be anticipated in the planning of a trial, study teams need to be flexible and react promptly to any problems that threaten recruitment or the implementation of the complex intervention. Thought should be given to the perspectives of midwives and obstetricians as recruiters and how clinic-intern processes could be adapted to correspond with the trial’s requirements.
Pediatric supratentorial glioblastoma: Experience at a Single Center in the past 6-year
Authors: Jiao Yang , Wang Meng , Liu Xueyou , Wang Junkuan , Wang Zeming , Luo Wenzheng , Yu Yang , Xu Keyan , Sun Hongwei 
Published: March 2021

Abstract
OBJECTIVE: Pediatric supratentorial glioblastoma (psGBM) is rare tumor of the central nervous system, the prognosis of it remains controversial due to their rarity. The aim of this study was to evaluate characteristics of pediatric supratentorial glioblastoma, effectiveness of modern treatment modalities, and detect factors related to prognosisMETHODS: Twenty-eight children under 18 years old were pathologically diagnosed with supratentorial glioblastoma at The First Aﬃliated Hospital of Zhengzhou University between 2014 and 2020.Epidemiological characteristics, clinical features, imaging features, functional outcomes, overall survival, progression-free survival according to multimodal treatments were reviewed retrospectively.RESULTS: Median survival time of children with supratentorial glioblastoma was 11 months and median progression-free survival was 7 months. Half-, one-year and two-year overall survival probabilities were 64.3%,42.9% and 14.3%, respectively. Half-, one-year and two-year progression-free survival probabilities were 53.6%,21.4% and 9.5%, respectively. Extent of resection(p=0.011) and postoperative concurrent chemoradiotherapy (p=0.032) are independent factors of prognosis while gender, age, initial symptom, tumor side, enhancement character, preoperative KPS and with or without cystoid variation and necrosis are not. Three patients lived longer than 2 years, one patient was alive at 46 months after diagnosis and no evidence of recurrence was found.CONCLUSION: Prognosis of pediatric supratentorial glioblastoma remains poor, and its prognosis may not be better than adult’s. Preoperative KPS score is a risk factor, but isn’t an independent risk factor. Concurrent chemoradiotherapy and gross total resection are the main methods to prolong life span.