bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten best practices to strengthen stewardship and sharing of water science data in Canada
Authors: Persaud Bhaleka D. , Dukacz Krysha A. , Saha Gopal C. , Peterson Amber , Moradi Laleh , O'Hearn Stephen , Clary Erin , Mai Juliane , Steeleworthy Michael , Venkiteswaran Jason J. , Kheyrollah Pour Homa , Wolfe Brent B. , Carey Sean K. , Pomeroy John W. , DeBeer Chris M. , Waddington James M. , Van Cappellen Philippe , Lin Jimmy 
Published: September 2021

AbstractWater science data are a valuable asset that both underpins the original research project and bolsters new research questions, particularly in view of the increasingly complex water issues facing Canada and the world. Whilst there is general support for making data more broadly accessible, and a number of water science journals and funding agencies have adopted policies that require researchers to share data in accordance with the findable, accessible, interoperable, reusable (FAIR) principles, there are still questions about effective management of data to protect their usefulness over time. Incorporating data management practices and standards at the outset of a water science research project will enable researchers to efficiently locate, analyse and use data throughout the project lifecycle, and will ensure the data maintain their value after the project has ended. Here, some common misconceptions about data management are highlighted, along with insights and practical advice to assist established and early career water science researchers as they integrate data management best practices and tools into their research. Freely available tools and training opportunities made available in Canada through Global Water Futures, The Gordon Foundation DataStream, the Digital Research Alliance of Canada Portage Network, Compute Canada, and university libraries, among others are compiled. These include webinars, training videos, and individual support for the water science community that together enable researchers to protect their data assets and meet the expectations of journals and funders. The perspectives shared here have been developed as part of the Global Water Futures programme's efforts to improve data management and promote the use of common data practices and standards in the context of water science in Canada. Ten best practices are proposed that may be broadly applicable to other disciplines in the natural sciences and can be adopted and adapted globally.
Design, production, and validation of the biological and structural performance of an ecologically engineered concrete block mattress: A Nature-Inclusive Design for shoreline and offshore construction
Authors: Sella Ido , Hadary Tomer , Rella Andrew J. , Riegl Bernhard , Swack Denise , Perkol-Finkel Shimrit 
Published: September 2021

Abstract
Over the past decade, the scientific community has studied, experimented, and published a notable body of literature on the ecological enhancement of coastal and marine infrastructure (CMI). The Nature-Inclusive Design (NID) approach refers to methods and technologies that can be integrated into the design and construction of CMI to create a suitable habitat for native species (or communities) whose natural habitat has been degraded or reduced. To examine the compliance of new environmentally sensitive technologies with structural requirements and fiscal restraints, while providing ecosystem and habitat value, this paper presents the findings of a structural–economical–biological analysis of ecologically engineered Articulated Concrete Block Mattresses (ACBMs). To evaluate the structural and biological performance of the Ecological Articulated Concrete Block Mattresses, a pilot project was deployed in April 2017 at Port Everglades, Florida, USA, and evaluated against controls of adjacent artificial structures and smooth-surface concrete blocks and monitored over a period of two years. The elements of ecological enhancement implemented in the fabrication and design of the ecologically enhanced ACBMs were comprised of bio-enhancing concrete additives and science-based designs. Based on the results of this study, these design alterations have increased the richness and diversity of sessile assemblages compared to control blocks and adjacent artificial structures and supported a higher abundance of mobile species. This ecological improvement was achieved within the operational limitations of conventional manufacturing and installation technologies, while complying with strict structural requirements for standard concrete marine construction. The results supported the working hypothesis and demonstrated that modifications of concrete composition, surface texture, and macro-design have the potential to increase the ecological value of concrete-based CMI and promote a more sustainable and adaptive approach to coastal and marine development in an era of climate resilience-building. Integr Environ Assess Manag 2022;18:148–162. © 2021 SETAC
KEY POINTS
Ecological enhancement was achieved within the operational limitations of conventional manufacturing and installation technologies. Ecological Articulated Concrete Block Mattresses comply with the strict structural requirements for coastal and marine construction. Design alterations have increased the richness and diversity of sessile assemblages compared to control blocks and adjacent artificial structures.
Prognostic value of the TCGA molecular classification in uterine carcinosarcoma
Authors: Travaglino Antonio , Raffone Antonio , Raimondo Diego , Arciuolo Damiano , Angelico Giuseppe , Valente Michele , Scaglione Giulia , D’alessandris Nicoletta , Casadio Paolo , Inzani Frediano , Mollo Antonio , Santoro Angela , Seracchioli Renato , Franco Zannoni Gian 
Published: September 2021

AbstractBackgroundThe TCGA molecular groups of endometrial carcinoma are “POLE‐mutated” (POLEmut), “microsatellite‐instable/mismatch repair‐deficient” (MSI/MMRd), “TP53‐mutated/p53‐abnormal” (TP53mut/p53abn), and “no specific molecular profile” (NSMP).ObjectivePrognostic assessment of the TCGA groups in uterine carcinosarcoma (UCS).Search strategySystematic review from January 2000 to January 2021.Selection criteriaStudies assessing the TCGA groups in UCS.Data collection and analysisProgression‐free survival (PFS) and overall survival (OS) were assessed by Kaplan–Meier and Cox analyses (reference: TP53mut/p53abn group) and compared with endometrioid and serous carcinomas (original TCGA cohort), with a significant P < 0.050.Main resultsFive studies with 263 UCS were included. Compared with TP53mut/p53abn UCS, MSI/MMRd UCS showed significantly better PFS (P < 0.001) but similar OS (P = 0.788), whereas NSMP UCS showed similar PFS (P = 0.936) and OS (P = 0.240). Compared with their endometrioid/serous counterparts, NSMP and TP53mut/p53abn UCS showed significantly worse PFS (P < 0.001 and P = 0.004) and OS (P < 0.001 and P < 0.001), while MSI/MMRd UCS showed similar PFS (P = 0.595) but significantly worse OS (P < 0.001). The POLEmut group showed neither recurrences nor deaths in both the UCS and the endometrioid/serous carcinoma cohorts.ConclusionPOLEmut UCS show excellent prognosis, whereas TP53mut/p53abn and NSMP UCS show a prognosis even worse than that of TP53mut/p53abn endometrioid/serous carcinomas. The prognosis of MSI/MMRd UCS remains to be defined.
Nutcracker syndrome as the main cause of left renal vein thrombus and pulmonary thromboembolism
Authors: Hori Kanta , Yamamoto Shota , Kosukegawa Maki , Yamashita Noboru , Shinno Yuichiro 
Published: September 2021

IntroductionLeft renal vein thrombus complicating nutcracker syndrome is relatively rare. To the best of our knowledge, there have been only four previous case reports. Furthermore, there have been no reports of pulmonary thromboembolism caused by nutcracker syndrome. Herein, we report a rare case of pulmonary thromboembolism caused by nutcracker syndrome and its clinical management.Case presentationA 40‐year‐old man was admitted to our hospital with acute left flank pain. Computed tomography angiography revealed compression of the left renal vein between the aorta and the superior mesenteric artery with a left renal vein thrombus. Furthermore, computed tomography revealed bilateral pulmonary thromboembolism. Rivaroxaban was administered as an anticoagulant. Twenty days after initiation, computed tomography revealed complete resolution of pulmonary thromboembolism and left renal vein thrombus, and repeated computed tomography showed no recurrence.ConclusionThis case report highlights nutcracker syndrome as a likely cause of pulmonary thromboembolism.
The development of mandatory practices for the testing and maintenance of synthetic turf fields in the National Football League
Authors: Jastifer James R. , McNitt Andrew S. , Mack Christina D. , Kent Richard W. , McCullough Kirk A. , Coughlin Michael J. , Anderson Robert B. 
Published: September 2021

AbstractSynthetic turf has become an increasingly common playing surface in athletics. Synthetic turf maintenance and athlete health are related and are important considerations at all levels of play. As part of the development of testing practices for the National Football League (NFL) game‐day surfaces, a literature search of MEDLINE and PubMed between the years 1990 and 2018 was conducted. Additionally, a taskforce was convened, and expert opinion was solicited from members through systematic interviews regarding synthetic turf design and maintenance practices in the NFL. All game‐day synthetic turf manufacturers were routinely solicited for input during development and implementation of the mandatory practices. Appropriate maintenance practices can improve the consistency of a synthetic playing surface. Methods for evaluating surface hardness and other aspects of synthetic turf have been developed. The relationships between current hardness testing methods and injury outcomes have been studied but are not well established. Consensus methods for evaluating surface traction and cleat release at potentially injurious loading levels are currently unavailable and needed. Mandatory practices were developed and have been implemented by the NFL, which have resulted in more consistent playing surfaces over the course of a season. Despite the extant gaps in knowledge, a formalized set of testing practices and maintenance has proven effective for reducing surface variability across synthetic surfaces in the NFL. Characteristics such as surface hardness, traction, and shoe–surface interaction, and the effects of surface maintenance procedures should be the focus of future research.
Integrative analysis of hub genes and key pathway in two subtypes of diffuse large B‐cell lymphoma by bioinformatics and basic experiments
Authors: Li Qian , Meng Ye , Hu Linhui , Charwudzi Alice , Zhu Weiwei , Zhai Zhimin 
Published: September 2021

AbstractBackgroundThe germinal center B‐cell (GCB) and activated B‐cell (ABC) subtypes of diffuse large B‐cell lymphoma (DLBCL) have a significant difference in prognosis. This study aimed to identify potential hub genes, and key pathways involved in them.MethodsDatabases including Gene Expression Omnibus (GEO), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and STRING were accessed to obtain potential crucial genes and key pathways associated with the GCB and ABC. Then qRT‐PCR and Western blot experiments were performed to verify the most clinically significant gene and pathway.ResultsThree cohort datasets from the GEO database were analyzed, including 195 GCB and 169 ABC samples. We identified 1113 differentially expressed genes (DEGs) between the GCB and ABC subtypes. The DEGs were mainly enriched in biological processes (BP). The KEGG analysis showed enrichment in cell cycle and Wnt signaling pathways. We selected the top 10 genes using the STRING database and Cytoscape software. We used 5 calculation methods of the cytoHubba plugin, and found 3 central genes (IL‐10, CD44, CCND2). CCND2 was significantly related to the prognosis of DLBCL patients. Besides, our experimental results demonstrated a significantly higher expression of CCND2 in the ABC‐type cell line than in the GCB‐type; it was proportional to the expression of key proteins in the Wnt signaling pathway.ConclusionCCND2 overexpression and Wnt pathway activation might be the main reasons for the poor prognosis of ABC‐DLBCL.
Twelve‐month organizational study examining the associations among behavioral healthcare worker's perceptions of autonomy, decision‐making power, organizational commitment, and burnout: Reconceptualizing the role of commitment in shaping staff member experiences of the work environment
Authors: W. Hales Travis , H. Nochajski Thomas , A. Green Susan , P. Koury Samantha 
Published: September 2021

AbstractPrevious research has demonstrated that behavioral healthcare workers' experiences of autonomy and decision‐making power in the workplace are positively associated with their commitment to the organization and negatively associated with occupational burnout. Models examining the relationships between workplace climate and staff member well‐being generally conceptualize workplace climates as predictors of individual commitment and burnout. However, the relationships among these constructs have primarily been explored in cross‐sectional study designs. The current study adds to the existing literature by examining the relationships among perceived autonomy and decision‐making power in the organizational climate, and individual levels of organizational commitment and burnout over a 12‐month period (N = 43). The study was done in a public hospital's behavioral healthcare department in the Western New York region. Cross‐lagged panel analyses were conducted to assess if time‐one scores on perceived autonomy and decision‐making power predicted time‐two scores of organizational commitment and burnout. Findings indicate that, contrary to popular conceptualization, individual staff member's commitment to the organization predicted future states of perceived autonomy and decision‐making power. Individual commitment to the organization may be a driving factor in how staff members experience and perceive the service environment.
A Model‐Based Framework to Inform the Dose Selection and Study Design of Emicizumab for Pediatric Patients With Hemophilia A
Authors: Yoneyama Koichiro , Schmitt Christophe , Chang Tiffany , Dhalluin Christophe , Nagami Sayaka , Petry Claire , Levy Gallia G. 
Published: September 2021

AbstractEmicizumab is a bispecific antibody mimicking the cofactor function of activated coagulation factor VIII to prevent bleeds in patients with hemophilia A. The dose selection for the first‐in‐child phase III study of emicizumab was addressed by pediatric pharmacokinetic prediction using an adult/adolescent population pharmacokinetic model developed in phase I‐I/II studies. The model was modified to incorporate functions describing the age‐dependent increase in body weight (BW) with or without clearance maturation to account for the differences in emicizumab pharmacokinetics between adults/adolescents and children. A minimal dose anticipated to achieve in children the same target efficacious exposure as for adults/adolescents was identified when considering BW and clearance maturation. It was the same BW‐based dose as for adults/adolescents and was selected for the starting dose for the pediatric study. Whether considering clearance maturation or not in addition to BW led to uncertainty in the pediatric pharmacokinetic prediction and dose selection, which informed implementation of a dose‐adapting scheme in the study design. Exposure matching to adults/adolescents was ultimately achieved in children with the starting dose, indicating that consideration of clearance maturation in addition to BW provided adequate pediatric pharmacokinetic predictions for emicizumab. This pharmacokinetic finding in conjunction with exposure‐response information served as a basis for the efficacy demonstrated in children, avoiding a time‐consuming process for exploring an optimal pediatric dose of emicizumab. This experience indicates that a model‐based framework helped optimize the pediatric dose selection and study design, thereby streamlining the development process with extrapolation, of emicizumab for children.
Limited, uneven progress in increasing racial and ethnic diversity of dental school graduates
Authors: Salsberg Edward , Brantley Erin , Westergaard Sara , Farrell Jenee , Rosenthal Christina 
Published: September 2021

AbstractPurpose/objectivesTo assess racial and ethnic diversity of graduates of each dental school compared to the diversity of populations they draw from and to assess changes over time nationally and by school.MethodsWe calculated diversity of graduates by school and nationally between 2010–2012 and 2017–2019 using the Integrated Post‐secondary Education Data System (IPEDS) and compared the diversity of each state's college age population using data from the American Community Survey. We accounted for differences between in‐state and out‐of‐state students attending public and private schools based on data from the American Dental Association's Survey of Dental Education Series. A diversity index (DI) was calculated for each school. A DI of 0.5 means that the representation of Black or Hispanic individuals among the graduates is half of their representation in the benchmark population.ResultsAmong the 63 dental schools analyzed, only seven had a DI of greater than 0.5 for Black graduates (two of which were Historically Black Colleges and Universities) in 2017–2019. For Hispanic graduates, 20 schools had a DI above 0.5. Nationally, while the number of Black graduates increased between 2010–2012 and 2017–2019, the percentage decreased from 5.8% to 5.1%. The percentage of Hispanic graduates increased from 6.4% to 8.7%.ConclusionsBlack and Hispanic individuals are underrepresented among dental school graduates. Increasing the diversity of the dental workforce could help address significant oral health disparities experienced by Black and Hispanic people. More needs to be done by the dental education community to increase racial and ethnic diversity of dental graduates.
Examining clinical training through a bicultural lens: Experiences of genetic counseling students who identify with a racial or ethnic minority group
Authors: Carmichael Nikkola , Redlinger‐Grosse Krista , Birnbaum Shira 
Published: September 2021

AbstractBiculturals are individuals who have had significant exposure to more than one culture and who possess more than one cultural frame of reference. In the United States, this term has been used to describe both immigrants and members of racial or ethnic minority groups who live within the majority white culture. Biculturals develop a distinct repertoire of social and cognitive skills and have been shown to engage in a process of cultural frame switching in response to salient cultural cues. Through a conceptual lens offered by current research on biculturalism, this article examines transcripts of focus groups we collected for a study on the clinical training experiences of genetic counseling students who identify with a racial or ethnic minority group. We conducted a constructivist grounded theory study, collecting data via 13 videoconference focus groups with 32 recent graduates of genetic counseling training programs who identify with a racial or ethnic minority group. We focus here on two of the thematic categories identified in that study related to participants’ experiences interacting with patients during supervised clinical rotations. We find three ways in which being bicultural influenced these genetic counselors’ patient interactions. First, participants described interactions with both culturally concordant and culturally discordant patients that highlighted the salience of their racial, ethnic, or cultural identity in these encounters. Second, they reported sensitivity to social nuances between and within cultures, reflecting the findings of prior research about heightened cultural awareness in biculturals. Third, they described switching cultural frames in response to their patients’ identities which, at times, created conflict between their professional and culturally concordant frameworks. The results of this study suggest that the influence of a student's racial, ethnic, or cultural identity on interactions with patients should be discussed within the supervisory relationship, and that being bicultural confers advantages in learning to provide culturally responsive care.
Automation and evaluation of the interactive homogenization tool HOMER
Authors: Joelsson L. Magnus T. , Sturm Christophe , Södling Johan , Engström Erik , Kjellström Erik 
Published: September 2021

AbstractThe interactive HOMER is automated by the use of a set of parameters. This approach retains the skill and flexibility of an interactive method, but adds the speed and reproducibility of an automatic method. The automation of the interactive HOMER also enables systematic testing. Its performance is evaluated by the homogenization of the Indecis homogenization benchmark datasets. The overall performance of the interactive HOMER compares well with the methods using the homogenization tools Climatol and ACMANT and surpass the performance of the standard automatic HOMER. All the homogenization methods reduce the initial error. The average residual error and all error percentiles below and including the 99th error percentile do not differ more than 0.3°C between interactive HOMER and the other methods. Interactive HOMER and Climatol report fewer homogeneity breaks than the true number, while standard automatic HOMER and ACMANT report more homogeneity breaks. Across the methods, a higher number of reported homogeneity breaks renders a higher share of the true homogeneity breaks to be detected, but also a higher share of the reported breaks to be false positives. On average the differences in the corrected times series are small between the methods implying that the choice of homogenization method is a matter of preference.