bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new model for COVID-19 control and its implementation in the city of Honghu, China: a case report
Authors: Wang He-ran , Gong Meng-chun , Sun Jing-Yuan , Sun Jian , Guo Yi , Liu Li , Zhu Hong 
Published: February 2021

Abstract
Background
Novel coronavirus pneumonia has been the most serious worldwide public health emergency since being identified in December 2019. The rapid spread of the pandemic and the strong human to human infection rate of COVID-19 poses a great prevention challenge. There has been an explosion in the number of confirmed cases in several cities near Wuhan, including the highest in Honghu, Jinzhou. Owing to the limited admission capacity and medical resources, increasing numbers of suspected cases of COVID-19 infection were difficult to confirm or treat.

Case presentation
Following the arrival of the Guangdong medical aid team on 11 February, 2020, COVID-19 care in Honghu saw changes after a series of solutions were implemented based on the ‘Four-Early’ and ‘Four-centralization’ management measures. The ‘Four-Early’ measures are: early detection, early reporting, early quarantine, and early treatment for meeting an urgent need like the COVID-19 pandemic. ‘Four-centralization’ refers to the way in which recruited medical teams can make full use of medical resources to give patients the best treatment. These solutions successfully increased the recovery rate and reduced mortality among patients with COVID-19 in Honghu.

Conclusions
This management strategy is called the ‘Honghu Model’ which can be generalized to enable the prevention and management of COVID-19 worldwide.
A label-free logic gate hairpin aptasensor for sensitive detection of ATP based on graphene oxide and PicoGreen dye
Authors: Zhang Jingjing , Xu Handan , Li Chunhui , Wang Yilin , Liu Debing , Zhao Shenghe 
Published: February 2021

Abstract
Background
In this paper, a simple, enzyme-free, label-free fluorescence, high sensitivity logic gate hairpin aptasensor was developed for adenosine triphosphate (ATP) detection based on graphene oxide (GO) and PicoGreen dye.

Methods
Using single-strand deoxyribonucleic acid (DNA) and adenosine triphosphate (ATP) as input signal and fluorescence signal as output signal, if single-strand DNA (DNA-L), single-strand DNA (DNA-S), and ATP were present at the same time, one segment of DNA-L formed a hairpin ring with ATP, and the other segment of DNA-L formed a completely complementary hairpin stem with DNA-S. The hairpin DNA was detached from the GO surface, and PicoGreen dye was embedded into the hairpin stem, and the fluorescence signal was enhanced. The molecular logic gate was constructed through the establishment of logic histogram, logic circuit, truth table, and logic formula. The biosensor-related performances including sensitivity, selectivity, and linearity were investigated, respectively.

Results
We have successfully constructed a AND logic gate. The detection limit of ATP is 138.0 pmol/L (3σ/slope) with detection range of 50–500 nmol/L (R2 = 0.98951), and its sensitivity is 4.748 × 106–6.875 × 108 a.u. (mol/L)−1.

Conclusions
The logic gate hairpin aptamer sensor has the advantages of high sensitivity, low detection limit, and low cost, and can be successfully applied to the detection of adenosine triphosphate (ATP) in actual human urine samples.
Fractal analysis as a useful predictor for determining osseointegration of dental implant? A retrospective study
Authors: Soylu Emrah , Coşgunarslan Aykağan , Çelebi Selin , Soydan Damla , Demirbaş Ahmet Emin , Demir Osman 
Published: February 2021

Abstract
Purpose
The present study aimed at evaluating the effectiveness of fractal analysis on determining the osseointegration of dental implants.

Material and methods
In a single center, retrospective clinical trial, patients with dental implants in the mandibular premolar/molar region, ASA I–II and < 65-year-old patients were included. Orthopantomograph (OPG) were taken before implant surgery (t0), within a week of surgery (t1), and 1 (t2) and 2 (t3) months after surgery, respectively. Three regions of interest (ROIs) from mesial, distal, and apical sites of the implants were chosen and fractal analysis (FA) was conducted with the box-counting algorithm using White and Rudolph’s method.

Results
A total of 39 patients 19 women and 20 men, with a mean age of 52.2 years (52.3 and 52.1 years, respectively) were included. The mean, minimum and maximum values of mesial (roi1), distal (roi2), and apical (roi3) surfaces were compared. The fractal dimension (FD) values of t1 were significantly lower compared with t0 as they decreased during the first week. FD values gradually increased after the first week although never exceeded the FD values of t0. Also, difference between mean FD values of t0 and t3 were found statistically significant (p < 0.05).

Discussion
FA is a promising and noninvasive method to predict osseointegration of a dental implant based on dental radiographs, and it can help shorten the total treatment time.
Pain-guided activity modification during treatment for patellar tendinopathy: a feasibility and pilot randomized clinical trial
Authors: Sprague Andrew L. , Couppé Christian , Pohlig Ryan T. , Snyder-Mackler Lynn , Silbernagel Karin Grävare 
Published: February 2021

AbstractBackgroundActivity modification is a key component of patellar tendinopathy treatment but there is a lack of evidence guiding activity modification prescription. Use of activity modification in treatment studies has varied widely and the impact of those recommendations has not been directly investigated or compared. The purpose of this study was to assess (1) the feasibility of using pain-guided activity modification during treatment for patellar tendinopathy and (2) if our outcome measures are responsive to changes in tendon health over the course of treatment.MethodsThis was an unblinded, randomized two-arm pilot and feasibility study randomized clinical trial with parallel assignment, conducted in Newark, DE. Individuals between the ages of 16 and 40 years old with patellar tendinopathy were included. Participants were randomly assigned to apain-guided activity(PGA) orpain-free activity(PFA) group using a spreadsheet-based randomization scheme.All participants received standardized treatment using a modified version of the heavy-slow resistance protocol 3×/week for 12 weeks. For the first 6 weeks, the PGA group used the Pain-Monitoring Model to guide activity outside of treatment and the PFA group was restricted from running, jumping, or activities that provoked their patellar tendon pain. Feasibility outcomes included recruitment, enrollment, randomization, compliance, and retention percentages. Clinical evaluations were conducted at baseline, 6, and 12 weeks to assess symptom severity, psychological factors, tendon morphology and mechanical properties, lower extremity function, and quadriceps muscle performance.ResultsIn a ~ 13-month period, 108 individuals were screened, 47/108 (43.5%) were eligible for participation, and 15/47 (32.0%) of those were enrolled (9 PGA, 6 PFA). The recruitment rate was 1.15 participants/month. The mean ± SD compliance with treatment was PGA: 86.1 ± 13.0% and PFA: 67.1 ± 30.7%. There was one missed evaluation session and two adverse events, which were not due to study interventions. Changes exceeding the smallest detectable change were observed for at least one outcome in each domain of tendon health.ConclusionsUse of pain-guided activity modification during exercise therapy for patellar tendinopathy was found to be feasible, and the proposed outcome measures appropriate. Computer-based allocation concealment, blinding of evaluators, and greater recruitment of high-level athletes should be implemented in future trials.Trial registrationClinicalTrials.gov identifier:NCT03694730. Registered 3rdof October, 2018.
Entomopathogenic efficacy of the endophytic fungi: Clonostachys sp. and Beauveria bassiana on Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) larvae under laboratory and greenhouse conditions
Authors: Mohamed Mahmoud Fadhela , Bendebbah Rachida , Benssaci Bouchra , Toudji Fethia , Tafifet Lamia , Krimi Zoulikha 
Published: February 2021

AbstractBackgroundEndophytic fungi are excellent sources of new natural bioactive products with potential for exploitation in medical, agricultural, and industrial fields. Beneficial effects of endophytes are not only limited to promoting plant growth, but also to react as plant protection agents against phytopathogenic microorganisms and plant pests. The tomato leaf miner,Tuta absoluta(Meyrick) (Lepidoptera: Gelechiidae) is one of the main tomato pests in South America and in the Mediterranean basin.ResultsIn the present work, the effectiveness of two endophytic fungiClonostachysspp. andBeauveria bassianawere tested againstT.absolutalarvae. Evaluation of the larvicidal effect in the laboratory by spraying 3 concentrations (D1= 4 × 107spores/ml,D2= 4 × 106spores/ml andD3= 4 × 105spores/ml) of fungal suspensions showed remarkable efficacy, which varied depending on the tested strain, concentration of application and time of exposure. Statistical analysis showed highly significant results on larval mortality rates for both endophytic than the control. After 15 days, dead larvae were mummified. Applications of tested isolates in greenhouse experiments confirmed their marked biological control efficacy than the synthetic insecticide (Emamectin benzoat). Number of mined leaves decreased depending on the contact time of the larvae with the fungal spores.ConclusionResults suggest that the two endophytic fungiB. bassianaandClonostachysspp. were very effective entomopathogenic fungi againstT. absoluta. Indeed, the present study revealed the pathogenicity ofClonostachysspp. againstT. absolutalarvae for the first time.
Psoriatic Arthritis Quality of Life Questionnaire: translation, cultural adaptation and validation into Brazilian Portuguese language
Authors: Gonçalves Rafaela Silva Guimaraes , Heaney Alice , McKenna Stephen P. , Carvalho Jonas Braynner , Vidal Maria Eduarda Lima , de Brito Marina Coelho Mores , Duarte Angela Luzia Branco Pinto 
Published: February 2021

Abstract
Introduction
Psoriatic arthritis (PsA) is a multifaceted inflammatory disease that can cause joint destruction and impair quality of life. The Psoriatic Arthritis Quality of Life Questionnaire (PsAQoL) was the first disease-specific tool for determining the impact of the disease on the quality of life of people with PsA.

Objectives
The primary objective was to develop and validate a Brazilian Portuguese version of the PsAQoL.

Methods
The UK PsAQoL was translated into Brazilian Portuguese using two translation panels. This translation then checked for face validity and construct validity with new samples of patients. Finally, a test-retest validation study was conducted with 52 patients with PsA. The survey included the Nottingham Health Profile (NHP) as a comparator instrument.

Results
Internal consistency and reproducibility were both excellent for the new adaptation (0.91 and 0.90 respectively Scores on the PsAQoL were found to correlate as expected with the comparator measure and the instrument was able to detect differences in score related to perceived severity of PsA, general health status and presence of a flare.

Conclusion
The Brazilian PsAQoL was found easy to understand and complete and has excellent reliability and construct validity. The new measure will be a valuable new tool for use in routine PsA practice and clinical trials.
Sex-dependent liver cancer xenograft models for predicting clinical data in the evaluation of anticancer drugs
Authors: Oh Sungryong , Jung Joohee 
Published: February 2021

Abstract
Background
The incidence and mortality of liver cancer show a great difference between the sexes. We established sex-dependent liver cancer xenograft models and investigated whether such sex-dependent models could be used to simultaneously evaluate the therapeutic and adverse effects of anticancer drugs for drug screening.

Results
In the in-vitro test, the cytotoxicity of anticancer drugs (cisplatin, 5-fluorouracil, and doxorubicin) was compared between male- and female-derived liver cancer cell lines. Cisplatin and 5-fluorouracil exhibited cytotoxicity without sex-difference, but doxorubicin showed dose-dependently significant cytotoxicity only in male-derived cells. Our results showed a strong correlation between preclinical and clinical data with the use of sex-dependent liver cancer xenograft models. Moreover, the male-derived Hep3B-derived xenograft model was more sensitive than the female-derived SNU-387-derived xenograft model against doxorubicin treatment. Doxorubicin showed more severe cardiotoxicity in the male xenograft model than in the female model. We investigated the occurrence frequency of doxorubicin-related cardiotoxicity using data obtained from the Korea Institute of Drug Safety & Risk Management Database, but no significant difference was observed between the sexes.

Conclusions
Our results suggest that sex-dependent xenograft models are useful tools for evaluating the therapeutic and adverse effects of anticancer drugs, because sex is an important consideration in drug development.
Systematic review: total knee arthroplasty (TKA) in patients with pigmented villonodular synovitis (PVNS)
Authors: Tan Yi Chuen , Tan Jia Yin , Tsitskaris Konstantinos 
Published: February 2021

Abstract
Background
To determine the functional outcomes, complications and revision rates following total knee arthroplasty (TKA) in patients with pigmented villonodular synovitis (PVNS).

Materials and methods
We conducted a systematic review of the literature. Five studies with a total of 552 TKAs were included for analysis. The methodological quality of the articles was evaluated using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) scale. Functional outcomes, complications and revision rates were assessed. The mean age was 61 years (range 33–94 years) and the mean follow-up period was 61.1 months (range 0.2–35 years).

Results
All the studies reported improvement in knee function following TKA. Post-operative stiffness was the most frequently reported complication, affecting 32.7% (n = 32) of patients in our review. Symptomatic recurrence of PVNS, component loosening, tibial-component fracture, instability and periprosthetic infection were the main factors leading to the need for revision TKA.

Conclusion
The findings of this review support the use of TKA to alleviate the functional limitations and pain due to knee degeneration in patients with PVNS. The operating surgeon should be aware of the increased risk of post-operative stiffness, as well as a potentially higher risk of infection. Implant survival should also be considered inferior to the one expected for the general population undergoing TKA.
High-degree atrioventricular block. An unusual presentation of Takotsubo cardiomyopathy: a case report
Authors: Revilla-Martí Pablo , Cueva-Recalde Juan F. , Linares-Vicente Jose A. , Río-Sánchez Sara , Ruiz-Arroyo Jose R. 
Published: February 2021

Abstract
Background
Takotsubo cardiomyopathy is a non-ischemic cardiomyopathy characterized by acute left ventricular systolic dysfunction with transient wall motion abnormalities without a culprit coronary stenosis or other concurrent diagnoses. Its coexistence with transient high-degree AV block is very infrequent.

Case presentation
A 61-year-old man presented with a new onset of high degree AV block without ST segment deviations developing an anterior and apical dyskinesia with a low left ventricular ejection fraction in the absence of coronary artery disease.

Conclusion
Atrioventricular block is an uncommon presentation of Takotsubo syndrome. The management of patients with relevant conduction disorders in this scenario is a challenge for the clinician. In case of persistence of advanced conduction disorders, it seems appropriate to implant a pacemaker.
Efficacy of heart transplantation in patients with a failing Fontan: a systematic review and meta-analysis
Authors: Hassan Wardah , Kotak Sohny , Khatri Mahima , Ahmed Areeba , Ahmed Jawad , Ali Syed Saad , Khan Taj M. 
Published: February 2021

Abstract
Background
As the population of patients with Fontan palliation grows, so does the number of patients with Fontan failure, necessitating heart transplantation. However, due to mainly small-sized studies, outcomes after heart transplantation in these patients remain unclear. The objective of this study was to review the available literature and conduct a meta-analysis to provide well-powered and generalizable estimates of outcomes after heart transplantation in patients with a failing Fontan.

Main text
PubMed, Embase, and MEDLINE databases were searched for original studies of patients with a failing Fontan who underwent heart transplantation. The outcomes included were 1-year and 5-year survival, acute rejection, renal dysfunction, sepsis, and multi-organ failure. Proportions were pooled using random effects models to derive pooled proportions (PPs) and corresponding 95% confidence intervals (CIs). Meta-regression analysis was done to study the effects of age and gender on key outcomes. Sixteen retrospective single-center cohort studies with 426 Fontan patients undergoing heart transplantation were included in this meta-analysis. Pooled analysis of this study further revealed that 1-year survival after heart transplantation was 79.9% ([75.8%, 83.7%]; I2 = 1.92%), and 5-year survival rate was 72.5% ([62.1%, 81.9%]; I2 = 72.12%). Secondary outcomes after heart transplantation of failed Fontan procedure were acute rejection (PP 20% [7.4%, 36.8%]; I2 = 72.48%), renal dysfunction (PP 31.3% [10.5%, 57.2%]; I2 = 75.42%), multi-organ failure (PP 18.6% [2.8 to 43.9%]; I2= 69.60%), and sepsis (PP 21.1% [9%, 36.8%]; I2 = 61.19%).

Conclusion
Cardiac transplantation in patients with a failing Fontan is associated with acceptable interventional success and improved survival rates.
Embelin: an HPTLC method for quantitative estimation in five species of genus Embelia Burm. f.
Authors: Vijayan K. P. Rini , Raghu A. V. 
Published: February 2021

Abstract
Background
The plants belonging to the genus Embelia, a significant tropical genus with many biological activities, are benefiting because of their robust medicinal properties. Embelin is one of the principal bioactive molecules responsible for the medicinal properties of the genus Embelia. The quantification of the embelin compound among different species in this genus has not yet been investigated, so still uncertain which species and which part should be accepted. The present study was intended to establish a speedy and precise high-performance thin-layer chromatographic (HPTLC) method for quantitative study of embelin in various plant parts of Embelia ribes, Embelia tsjeriam-cottam, Embelia basaal, Embelia adnata, and Embelia gardneriana.

Result
This research confirmed the method as per the International Conference on Harmonization (ICH) guidelines. We achieved separation on silica gel 60 F254 HPTLC plates using propanol: butanol: ammonia (7:3:7 v/v/v) as a mobile phase. Densitometry scanning performed for detection and quantification at 254 nm and 366 nm. Among the species investigated, the highest amount of embelin was found in E. ribes fruits.

Conclusion
Embelia ribes fruits are the best source of embelin. Embelin was first described in the endemic species, such as E. adnata and E. gardneriana. The method illustrated in this research may be applied for quantification of embelin and fingerprint analysis of other species within Embelia genus or described genera and chemo taxonomic studies of this genus.
Disparities in Refusal of Locoregional Treatment for Prostate Adenocarcinoma
Authors: Dee Edward Christopher , Arega Melaku A. , Yang David D. , Butler Santino S. , Mahal Brandon A. , Sanford Nina N. , Nguyen Paul L. , Muralidhar Vinayak 
Published: February 2021

PURPOSE: We assessed sociodemographic factors associated with and survival implications of refusal of potentially survival-prolonging locoregional treatment (LT, including radiotherapy and surgery) despite provider recommendation among men with localized prostate adenocarcinoma. METHODS: The National Cancer Database (2004-2015) identified men with TxN0M0 prostate cancer who either received or refused LT despite provider recommendation. Multivariable logistic regression defined adjusted odds ratios (AORs) with 95% CI of refusing LT, with sociodemographic and clinical covariates. Models were stratified by low-risk and intermediate- or high-risk (IR or HR) disease, with a separate interaction analysis between race and risk group. Multivariable Cox proportional hazard ratios compared overall survival (OS) among men who received versus refused LT. RESULTS: Of 887,839 men (median age 64 years, median follow-up 6.14 years), 2,487 (0.28%) refused LT. Among men with IR or HR disease (n = 651,345), Black and Asian patients were more likely to refuse LT than White patients (0.35% v 0.29% v 0.17%; Black v White AOR, 1.75; 95% CI, 1.52 to 2.01; P < .001; Asian v White AOR, 1.47; 95% CI, 1.05 to 2.06; P = .027, race * risk group interaction P < .001). Later year of diagnosis, community facility type, noninsurance or Medicaid, and older age were also associated with increased odds of LT refusal, overall and when stratifying by risk group. For men with IR or HR disease, LT refusal was associated with worse OS (5-year OS 80.1% v 91.5%, HR, 1.65, P < .001). CONCLUSION: LT refusal has increased over time; racial disparities were greater in higher-risk disease. Refusal despite provider recommendation highlights populations that may benefit from efforts to assess and reduce barriers to care.
Lateral diffusion on a frozen random surface
Authors: Ohta Takao , Komura Shigeyuki 
Published: February 2021

Abstract
The lateral diffusion coefficient of a Brownian particle on a two-dimensional random surface is studied in the quenched limit for which the surface configuration is time independent. We start with the stochastic equation of motion for a Brownian particle on a fluctuating surface, which has been derived by Naji and Brown. The mean square displacement of the particle projected on a base plane is calculated exactly under the condition that the surface with a constant shape has no spatial correlation. We prove that the obtained lateral diffusion coefficient is in between the known upper and lower bounds.
Lower and upper bounds for unilateral coherence and applying them to the entropic uncertainty relations
Authors: Dolatkhah H. , Haseli S. , Salimi S. , Khorashad A. S. 
Published: February 2021

Abstract
In this paper, a method is provided for obtaining the entropic uncertainty relations in the presence of a quantum memory by using quantum coherence. In the method, firstly, one can use the quantum relative entropy of quantum coherence to obtain the uncertainty relations. Secondly, these relations are applied to obtain the entropic uncertainty relations in the presence of a quantum memory. In comparison with other methods this approach is much simpler. Also, for a given state, the upper bounds on the sum of the relative entropies of unilateral coherences are provided, and it is shown which one is tighter. In addition, using the upper bound obtained for unilateral coherence, the nontrivial upper bound on the sum of the entropies for different observables is derived in the presence of a quantum memory.