bluuebunny/crossref_metadata_2025_split huggingface dataset:
Condutas do Enfermeiro em Situações de Urgências e Emergências Obstétricas / Nurse's Conduct in Situations of Obstetric Urgency and Emergencies
Authors: Silva Maria Andressa Bezerra da , Evangelista Brenda Pinheiro , Feitosa Jardenia Pereira , Evangelista Breno Pinheiro , Nóbrega Riani Joyce Neves 
Published: August 2021

Introdução: O enfermeiro obstetra junto a equipe multidisciplinar diante de situações de urgência e emergência obstétrica deve prestar assistência de forma holística com a finalidade de promover e minimizar o sofrimento materno fetal. Objetivo: Analisar por meio da literatura, as principais condutas de enfermeiros frente a situações de urgências e emergências obstétricas. Metodologia: Trata-se de um revisão integrativa de literatura realizada por meio de seis fases, através dos Descritores em Ciências da Saúde (DeCs): cuidados de Enfermagem", "Emergências" e "Enfermagem obstétrica". Os critérios de inclusão artigos em texto completo, língua portuguesa, e publicados no período de 2015 a 2020, e os critérios de exclusão foram: artigos de revisão, livros, capítulos de livros, entre outros formatos de textos e que não respondessem à pergunta norteadora do estudo. Incialmente foram encontrados 91 artigos a partir dos critérios de inclusão, após os critérios de inclusão ficaram 08 artigos. Resultados e Discussões: Foram estabelecidas duas categorias: (I) Práticas dos enfermeiros diante de situações de urgências e emergências obstétricas e (II) Atendimento à mulher no ciclo gravídico nos serviços de urgência/emergência dos hospitais. As categorias mostraram a importância da assistência holística da enfermagem para a resolutividade das intervenções realizadas. Considerações finais: Desta forma, percebe-se a necessidade da ampliação das estratégias para a classificação de risco e acolhimento em casos de urgência e emergência obstétrica, no sentido de ampliar o acolhimento para essas mulheres e o tratamento de forma eficaz.
Impactos das Condições de Trabalho na Saúde dos Professores em uma Escola Pública de Paranaíta - MT / Impacts of Working Conditions on Teachers' Health in a Public School in Paranaíta - MT
Authors: Souza Alice Brito de , Marques Marilaine De Castro Pereira , Souza Eunice Brito de , Chaves Sidney Da Silva , Gabriel Aparecida Pacheco , Vizzer Marlize Reffatti Zinelli 
Published: August 2021

Resumo: O mal-estar docente é caracterizado pelo adoecimento de professores, como resultado do caráter negativo de elementos que afetam suas personalidades no ambiente de trabalho. A presente investigação teve por objetivo geral pesquisar como os professores do 6° ao 9° ano de uma Escola Pública no município de Paranaíta, estado de Mato Grosso, concebem suas condições de trabalho e o impacto destas na própria saúde. Desenvolveu-se a pesquisa no período de fevereiro a novembro de 2018. Utilizou-se os métodos indutivo, descritivo e de campo, sendo a coleta de dados realizada por questionário. Todos os professores abordados afirmaram que a formação continuada da escola era de relevância e um deles destacou que esta não contempla questões correlatas aos anos finais do Ensino Fundamental. Dois dos pesquisados declararam que choram muito e que se medicam para continuarem trabalhando. Três dos pesquisados sabiam o que é mal-estar docente e o associou a sintomas manifestados na saúde de ambos, tais como limitações da voz, dores de cabeça, ansiedade e depressão. Uma gestão democrática, solidária e sensível gerencia conflitos e percebe quando os professores estão precisando de apoio pedagógico e ajuda médica, de forma a diminuir as pressões no ambiente de trabalho. Os resultados dessa pesquisa poderão ser de relevância para fortalecer o movimento de alerta sobre o mal-estar docente, uma síndrome que acarreta prejuízos aos docentes, alunos, ao sistema de ensino e a sociedade.
Principais Metodologias de Gerenciamento de Riscos: Uma Revisão Bibliográfica / Main Risk Management Methodologies: A Bibliographic Review
Authors: Barbosa Raille Dos Santos , Pinheiro Francisco Alves , Crisóstomo Antonio Pires 
Published: August 2021

Resumo: O gerenciamento de riscos é de extrema importância para as organizações, ao passo em que permite a antecipação aos riscos, através de sua identificação, análise e tomada de decisão acerca de medidas corretivas e, principalmente, preventivas, constituindo a principal ferramenta de apoio à garantia da saúde e segurança dos colaboradores. Dito isto, temos o presente estudo com o objetivo de identificar os principais métodos de gerenciamento de riscos, a partir de fontes nacionais, e com base nas normas de regulamentação brasileiras. As ferramentas apresentadas neste estudo serão a Análise Preliminar de Riscos (APR), a Série de Riscos e a Análise de Árvore de Falhas. A metodologia se constituiu na pesquisa bibliográfica, fundamentada na análise de livros, dissertações, artigos de profissionais da área, entre outras fontes compreendidas, em grande maioria, em períodos posteriores a 2010. Desta forma, foi possível conhecer as principais ferramentas, bem como a construção e aplicação que cada uma delas, colaborando para a disseminação deste conhecimento e demonstrando como as metodologias de gerenciamento de riscos auxiliam na promoção da saúde e segurança no ambiente laboral.
Reflexo da COVID-19 em asmáticos
Authors: Santos Lins de Oliveira Guilherme , Cavalcanti Pires de Azevedo Thomás , Aguiar Costa Rayane , Gomes de Mendonça Vasconcelos Júlia Maria , Monteiro da Cruz Cristiane , Reis Gonçalves Marcos 
Published: August 2021

O novo coronavírus, descoberto em dezembro de 2019, é o agente causador da pneumonia grave que gerou uma pandemia global. O reconhecimento dos fatores de risco e proteção são essenciais para direcionar o seguimento de novos tratamentos e estratégias de prevenção de infecções. Este estudo tem como objetivo avaliar a influência da asma frente a pandemia pelo novo coronavírus, no que tange à fisiopatologia dos quadros patológicos, aos fatores de risco, às formas terapêuticas, às comorbidades associadas e aos atuais protocolos que estão sendo utilizados em tal cenário. O estudo baseia-se em uma pesquisa descritiva de revisão integrativa da literatura. Limitou-se, para estabelecer a relação da asma e COVID-19, artigos publicados nos anos de 2019 e 2020, nas bibliotecas virtuais PubMed e BVS. Asma é uma doença respiratória crônica caracterizada pela inflamação das vias aéreas, hiper-responsividade, produção exacerbada de muco e remodelação. O gatilho mais frequente da patologia é a infecção das vias aéreas, especialmente de origem viral. O sistema imunológico inato do paciente asmático é incapaz de impedir a disseminação desses vírus para as vias respiratórias inferiores. Atualmente, o Centro de Controle e Prevenção de Doenças e a Organização Mundial de Saúde sugerem que pacientes com asma moderada e grave podem estar em maior risco para os casos graves de infecção pelo SARS-CoV-2, entretanto, na literatura, não há achados que corroboram. Sendo assim, vê que o estudo e novas associações devem ser continuados, a fim de melhor compreender a relação entre a asma e a COVID-19.
“He remains a second person no matter the age”: Historical and Contemporary Perceptions of Childlessness and Adoption in Nigeria
Authors: Chapdelaine Robin P. 
Published: August 2021

AbstractAs a consequence of infertility, some Southeastern Nigerians adopt children as a way to fulfill social and emotional voids. Through the use of secondary sources, colonial documents, legal analyses, clinician reports, and nearly two dozen interviews with residents of Aba, Calabar, Enugu, and Owerri, this article examines Nigerian perceptions of the incorporation of nonbiological children into their households. This study reflects upon the relationship between slavery, pawnship, fosterage, the incorporation of “house” children, and adoption in a historical context and illustrates that former social stigmas attached to subordinate statuses influence the choices infertile couples make. I argue that the taboo associated with adoption is steeped in the legacy of slavery and other forms of child trafficking, and such sentiments will prevail as long as shadow markets wherein children are bought and sold continue to exist.L’infertilité pousse certains Nigérians du sud-est à adopter des enfants pour combler les vides sociaux et émotionnels. Grâce à l’utilisation de sources secondaires, de documents coloniaux, d’analyses juridiques, de rapports de cliniciens et de près de deux douzaines d’entretiens avec des habitants d’Aba, Calabar, Enugu et Owerri, cet article examine les perceptions nigérianes de l’incorporation d’enfants non biologiques dans leurs ménages. Cette étude explore la relation entre l’esclavage, le gage, le placement familial, l’incorporation d’enfants «au foyer» et l’adoption dans un contexte historique et illustre que les anciens stigmates sociaux attachés aux statuts subordonnés influencent les choix que font les couples infertiles. Nous soutenons que le tabou associé à l’adoption est imprégné de l’héritage de l’esclavage et d’autres formes de traite des enfants, et que de tels sentiments continueront à prévaloir tant que les marchés parallèles où les enfants sont achetés et vendus continueront d’exister.
HAGLR promotes neuron differentiation through the miR-130a-3p-MeCP2 axis
Authors: Wei Bo , Xiao Gui-rong , Wu Cheng-long , Xu Yi-qin 
Published: August 2021

Abstract
Parkinson’s disease (PD) is a prevalent neurodegenerative disease. Currently, the molecular mechanisms underlying the progressions of PD are not fully understood. The human neuroblastoma cell line SH-SY5Y has been widely used as an in vitro model for PD. This study aims to investigate the molecular mechanisms of the non-coding RNA-mediated SH-SY5Y differentiation induced by retinoic acid (RA). By microArray analysis, lncRNA HAGLR was observed to be significantly upregulated during the RA-induced SH-SY5Y differentiation. Silencing HAGLR blocked the RA-induced SH-SY5Y differentiation. Moreover, bioinformatical analysis illustrated that miR-130a-3p contains binding sites for HAGLR. The RNA-pull down assay and luciferase assay demonstrated that HAGLR functioned as a ceRNA of miR-130a-3p in SH-SY5Y cells. Overexpression of miR-130a-3p effectively inhibited SH-SY5Y differentiation. We identified MeCP2, a vital molecule in neuronal diseases, to be a direct target of miR-130a-3p in SH-SY5Y cells by western blot and luciferase assays. The rescue experiments verified that recovery of miR-130a-3p in HAGLR-overexpressing SH-SY5Y cells could successfully overcome the RA-induced SH-SY5Y differentiation by targeting MeCP2. In summary, this study reveals a potential molecular mechanism for the lncRNA-HAGLR-promoted in vitro neuron differentiation by targeting the miR-130a-3p-MeCP2 axis, contributing to the understanding of the pathogenesis and progression of PD.
Structural characterization of microcrystalline and nanocrystalline cellulose from Ananas comosus L. leaves: Cytocompatibility and molecular docking studies
Authors: Sainorudin Muhammad Hanif , Abdullah Nur Athirah , Asmal Rani Mohd Saiful , Mohammad Masita , Mahizan Munirah , Shadan Nursyazwani , Abd Kadir Nurul Huda , Yaakob Zahira , El-Denglawey Adel , Alam Mahboob 
Published: August 2021

Abstract
The present study focused on the preparation of microcrystalline cellulose (MCC) and nanocrystalline cellulose (NCC) from pineapple (Ananas comosus L.) leaves using chemical treatments followed by acid hydrolysis. Pineapple leaves could be used in medical applications such as drug delivery carriers. Advanced spectroscopy techniques such as Fourier-transform infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) were used to analyze the physical, chemical, and morphological features of the isolated MCC and NCC; the results indicated the needle-shaped form of nanostructures with good purity and high crystallinity index of 75.00 and 76.38%, respectively. In addition, inhibition of the treated MRC-5 cells with all the samples revealed that the percentage of cell viability was less than 30%, which is an interesting finding given their role in the cytotoxicity effect of MCC and NCC. It appears that MCC and NCC derived from pineapple leaves have lower toxicity. As a result, the developed MCC and NCC can be used in pharmaceutical applications as a novel drug delivery system. Molecular docking was performed to understand the non-bonding interaction of cellulose with human acid-beta-glucosidase (β-Glc) (PDB: 1OGS). The docking result shows that cellulose unit docked within the active pocket of the enzyme by forming hydrogen bonds against ASN19, THR21, and VAL17 with distances of 2.18, 1.93, and 2.92 Å, respectively, with binding energy (−5.0 kcal/mol) resulting in close interaction of cellulose unit with the receptor.
Laboratory parameters predicting mortality of adult in-patients with COVID-19 associated cytokine release syndrome treated with high-dose tocilizumab
Authors: Lakatos Botond , Szabo Balint Gergely , Bobek Ilona , Gopcsa Laszlo , Beko Gabriella , Kiss-Dala Noemi , Petrik Borisz , Gaspar Zsofia , Farkas Balazs Ferenc , Sinko Janos , Remenyi Peter , Szlavik Janos , Valyi-Nagy Istvan 
Published: August 2021

AbstractLarge randomized clinical trials in severe Coronavirus Disease 2019 (COVID-19) patients have proven efficacy of intravenous tocilizumab. Our aim was to describe the laboratory parameters predicting in-hospital mortality of patients with tocilizumab administration in COVID-19 associated cytokine release syndrome (CRS).We evaluated high-dose (8 mg/kg) intravenous tocilizumab administration in severe and critically ill COVID-19 adult patients fulfilling predefined strict CRS criteria. A single-centre, prospective, observational cohort study was carried out among consecutive adult (≥18 years of age) in-patients with COVID-19 between April 1 and December 31, 2020. The primary endpoint was 28-day all-cause mortality. The changes in laboratory parameters from baseline on day 7 and 14 after administration of tocilizumab were analysed.In total, 1801 patients were admitted to our centre during the study period. One hundred and six patients received tocilizumab, and among them 62 (58.5%) required intensive care unit admittance while 25 (23.6%) deceased. At day 7 after tocilizumab administration, inflammatory markers (CRP, IL-6, ferritin) and lactate dehydrogenase (LDH) values were significantly lower among survivors. Subsequently, at day 14, differences of IL-6 and LDH levels has become more pronounced between subgroups. Restoration of absolute lymphocyte count (ALC) by day 7 and 14 was insufficient among patients who died.In our cohort, administration of high-dose tocilizumab for COVID-19 patients with CRS demonstrated clinical and sustained biochemical parameter improvement in 76.4%. In this patient population high and increasing LDH, IL-6, and low ALC levels had a predictive role for mortality.
Pharmacokinetics of tectorigenin, tectoridi, irigenin, and iridin in mouse blood after intravenous administration by UPLC-MS/MS
Authors: Li Jianbo , Yao Yuqi , Zhou Minyue , Yu Zheng , Jin Yinan , Wang Xianqin 
Published: August 2021

Abstract
Tectorigenin, tectoridin, irigenin, and iridin are the four most predominant compounds present in She Gan. She Gan has been used in traditional Chinese medicine because of its anti-inflammatory, hepatoprotective, anti-tumor, antioxidant, phytoestrogen-like properties. In this paper, a UPLC-MS/MS method was developed to measure the pharmacokinetics of tectorigenin, tectoridin, irigenin, iridin after intravenous administration in mice. A UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm particle size) chromatographic column was utilized for separation of the four target analytes and internal standard (IS), and the analysis of blood plasma samples; the mobile phase consisted of an acetonitrile-water (w/0.1% formic acid) gradient elution. Electron spray ionization (ESI) positive-ion mode and multiple reaction monitoring (MRM) mode was used for quantitative analysis of the analytes and internal standard. The four compounds were administered intravenously (sublingual) at doses of 5 mg/kg. After blood sampling, samples were processed and then analyzed by UPLC-MS/MS. The linearity of the method was robust over the concentration range of 2–5,000 ng/mL. The intra-day precision of the analysis was within 15%, the inter-day precision was within 12%, and the accuracy was between 92% and 110%. The recoveries were 65–68%, and the matrix effect was 93–109%. The established UPLC-MS/MS detection method was then successfully applied to study the pharmacokinetics of tectorigenin, tectoridin, irigenin, iridin in mice.
Effect of different salt concentration on the physical properties of frozen thawed egg yolk
Authors: Hidas Karina Ilona , Németh Csaba , Le Nguyen Lien Phuong , Visy Anna , Tóth Adrienn , Friedrich László , Nyulas-Zeke Ildikó Csilla 
Published: August 2021

AbstractFreezing can enhance the storage time of liquid egg products, but egg yolk undergoes an irreversible textural and structural change when it is cooled to –6 °C. In this study, the effects of different salt concentrations on the physical properties of frozen-thawed egg yolk were investigated.The pasteurised liquid egg yolk (LEY) was treated with 4, 5, and 6% of NaCl before freezing and it was stored at –18 °C for 4 weeks. The colour, pH, and rheological characteristics (firmness, consistency, cohesiveness, and index of viscosity) of yolk samples were evaluated before and after freezing.Salt treatment resulted in preventing gelation, with decreasing firmness, consistency and viscosity compared to control samples. The pH of all yolk samples increased during frozen storage. The lightness value decreased in treated samples and increased in the control sample after freezing.The results indicated that the applied salt concentrations could inhibit protein aggregation of LEY induced by freezing during the storage period. At least 5% salt concentration could reduce effectively the changes in rheological properties.
Design and characterization of 2D MXene-based electrode with high-rate capability
Authors: Wang Xuehang , Bannenberg Lars 
Published: August 2021

AbstractMXenes, two-dimensional transition metal carbides and nitrides, are promising materials for electrochemical energy storage application due to their redox-active surface and flexible interlayer space. Among all reported MXene-based electrodes, some have shown significantly better high-rate energy storage capabilities. Hence, it is crucial to have a systematic understanding on the decisive factors of the rate capability in the MXene family. This article discusses the impact of material properties at three levels, including intralayer composition, interlayer space and morphology, on the charge transfer and ion transport, revealing all the possible rate-limiting factors of MXene-based electrodes. We also describe systematic methods to characterize MXene electrodes as a detailed fundamental understanding of the structural and chemical properties, and the charge storage mechanisms crucial for rationally designing MXene-based electrodes.
Graphic abstract
SÜLEYMAN DEMİREL ÜNİVERSİTESİ TIP FAKÜLTESİ TIP TARİHİ GÖRSELLERİ
Authors: İNCE Fuat , KOLCU Giray 
Published: August 2021

Süleyman Demirel Üniversitesi Tıp Fakültesi 2016
yılından itibaren mezuniyet öncesi tıp eğitimi programının
akreditasyonu sürecine girerek tıp eğitimi kalitesini
daha da artırmayı amaçlamıştır. Bu kapsamda
mevcut imkân ve kabiliyetlere yenilerinin eklenmesi
ve var olanların da geliştirilmesi için çeşitli çalışmalar
başlatılmıştır.
Akreditasyon faaliyetlerini tamamlayıcı mahiyetteki bu
çalışmada Tıp Fakültesi Dekanlık Binası’nın tıp tarihi
görselleri ile donatılması amaçlanmaktadır.
Görseller birbirlerini tamamlayan üç farklı konseptle
yerleştirilmiştir. Bunlardan ilki; Dekanlık Binası’nın
hemen girişine yerleştirilen, ilk girişte öğrencileri ve
Dekanlık Binası’na giren diğer kişileri karşılayan iki
görseldir. İkinci konsept görsellerinde yine ilk olarak
üç büyük hekimin (Hipokrat, Galen ve İbn-i Sina) görseline
yer verilmiştir. Üçüncü grup görseller ise modern
tıbbın gelişimine büyük katkı sağlamış hekimler
ve diğer bilim insanları ile tıpta yaşanan önemli gelişmelerle
ilgilidir.
Fakülte girişinden itibaren yeni dersliklere (amfilere)
giden geniş, aydınlık ve ferah koridorun ve hemen alt
katında yer alan öğrenci dolaplarının bulunduğu geniş
salona giden koridorun tıp tarihi görselleri ile donatılması
tamamlanmıştır.
Sonuç olarak tıp tarihi ve tıp eğitimi açısından görsel
farkındalık oluşturan, öğrencilerin dikkatini tıp tarihine
çeken bu görseller Tıp Fakültesi Dekanlık Binası’nın
görünümünü zenginleştirmiş ve tıbbın tarihsel gelişim
sürecine verilen önemin bir göstergesi olarak var olan
kurum kimliği değerini ve kültürünü yansıtmaktadırlar.
Sensorial, Nutritional and Shelf Life Evaluation of Bio-fortified Millet based Cookies Supplemented with Carrot Powder and Sesame
Authors: Bansal Tanvi , Kawatra Asha , Sangwan Veenu 
Published: August 2021

Background: Micronutrient deficiency forms an important global health issue, leading to poor mental and physical development in children, predisposing deficient people to various diseases and losses in potential and productivity. To curb this form of malnutrition, fortification of foods via agronomic practices and manually can prove to be useful. Methods: Bio-fortified pearl millets were used for the development of nutrient-dense cookies, that were enriched with micronutrients. Cookies were prepared in eight variations employing both varieties of pearl millets, separately. First, Control-without Carrot powder and sesame; Type 1, Type 2 and Type 3 products contained 20%, 30% and 40% carrot powder, respectively along with 20% sesame. The cookies were evaluated for their organoleptic attributes, nutritional composition and shelf life. Result: Cookies were found highly acceptable for organoleptic scores. The nutritional parameters were found to be ranging between 5.26-6.17, 7.89-12.65, 23.31-27.61, 1.37-2.81 and 1.18-1.87 per cent for moisture, crude protein, crude fat, ash and crude fiber, respectively. Similarly 64.11-345.76, 7.05-8.98 and 2.77-3.95 mg/100g for calcium, iron and zinc, respectively, whereas β-carotene was evaluated varying from 13.27 to 583.01 μg/100g for control and Type 2 cookies. The cookies contribute multiple macro and micro nutrients and also have a shelf life of two months when stored in air-tight containers with suitable ambient conditions.
The views of English teachers’ towards school management and school managers*
Authors: Kasot Nazim , Guneyli Mehmet 
Published: August 2021

In this research, it is aimed to evaluate the teaching of English in North Cyprus on the basis of educational administration. The scope of education management was determined according to the opinions concerning school management and school administrators. Qualitative research approach and case study model were used as basis in the research. Participants were selected in accordance with the purposeful sampling, maximum diversity and easily accessible case sampling. Accordingly, 23 English teachers from 6 districts working in secondary education of Norhern Cyprus Ministry of National Education were selected. The data were obtained through interviews and analyzed by content analysis. It is an important result of this research that school administrators have positive perspectives towards English teaching. It has been revealed that school administrators do not expect different tasks from English teachers when compared to other course teachers. It was noteworthy that the building of English language classrooms was one of the striking expectations of English teachers from school administrators.
Keywords: Foreign language education, English teaching, school management, school administrators, North Cyprus;