bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study and comparison of wear behaviour of Ni-Al2O3 coatings deposited by hot and cold spray
Authors: Dhand Deepak , Grewal Jasmaninder Singh , Kumar Parlad 
Published: December 2021

Abstract
The sliding wear of hot and cold spray nickel-alumina coatings on SA 213-T 91 boiler steel has been evaluated and compared. The investigation was conducted with pin-on-disc apparatus. The wear testing was done by varying normal loads of 30, 40, and 50 N at a constant sliding velocity of 1 ms−1. Then another set of experimentation was done at different sliding velocities of 0.5, 1, and 2 ms−1 at a constant normal load of 30 N. This experimentation was designed to study the effect of varying normal loads and sliding velocities on the wear performance of coatings developed with hot and cold spray techniques. The variation of friction coefficient and wear rate with variation in normal loads and sliding velocities were plotted and analyzed. The evaluation of wear mechanisms and characteristics of Ni-Al2O3 coatings is done with the help of weight change measurements and FE-SEM analysis. The wear resistance of hot spray coatings was found better at high normal loads and sliding velocities in comparison to cold sprayed coatings.
Synthesis of Ag decorated TiO2 nanoneedles for photocatalytic degradation of methylene blue dye
Authors: Ridha Noor J , Mohamad Alosfur Firas K , Kadhim Hiba Basim Abbas , Ahmed Luma M 
Published: December 2021

Abstract
Water pollution due to the discharge of industrial effluents such as dyes is a serious concern that requires a potential remedy. In this context, photocatalysis is a potent and ecofriendly strategy to degrade these toxic water effluents. In this study, a novel approach to prepare TiO2 nanoneedles decorated with Ag nanoparticles is reported. The sample was prepared using modified photodeposition and was annealed at 400 °C. The x-ray diffraction (XRD) revealed that TiO2 in anatase phase with the presence of Ag were prepared successfully. The corresponding crystalline size of TiO2 and Ag were 6.86 nm and 3.94 nm, respectively. The scanning electron microscopy (SEM) showed that the prepared TiO2 exhibited nanoneedles structure decorated with Ag nanoparticles. The prepared sample exhibited impressive photocatalytic performance toward degrading of 50 ppm Methyl Blue (MB) in the presence of UV irradiation. Using catalyst dose of 4 mg the photodegradation efficiency (PDE) reached to 98.7% after 50 min of UV irradiation. This improved photocatalytic activity is attributed to high catalytic activity and surface area of the synthesized Ag decorated TiO2 nanoneedles.
Tunable topology and berry curvature dipole in transition metal dichalcogenide Janus monolayers
Authors: Joseph Nesta Benno , Roy Saswata , Narayan Awadhesh 
Published: December 2021

Abstract
Janus transition metal dichalcogenides, with intrinsic mirror asymmetry, exhibit a wide array of interesting properties. In this work, we study Janus monolayers derived from WTe2 using first-principles and tight-binding calculations. We discover that WSeTe and WSTe are topologically trivial, in contrast to the parent quantum spin Hall insulator WTe2. Motivated by the growing interest in non-linear Hall effect, which also requires asymmetric structures, we investigate the Berry curvature and its dipole in these Janus systems and find that they exhibit strikingly large values of Berry curvature dipole, despite being in the topologically trivial phase. We track down the origin of this behaviour and put forth a low-energy massive Dirac model to understand the central features of our ab inito computations. Our predictions introduce Janus monolayers as promising new platforms for exploring as well as engineering non-linear Hall effect.
An organic, threshold voltage based, all PMOS, voltage reference generator for flexible sensor tags
Authors: Azimi Mohammad , Habibi Mehdi , Karimi-Alavijeh Hamidreza 
Published: December 2021

Abstract
The developments and advances achieved in organic semiconductors have promised lower costs for integrated circuit production and also fabrication of electronic circuits using printed technology on unconventional substrates such as plastic, clothing, and even skin. An important building block essential to most electronic circuits is a voltage, process, and temperature independent potential generator which can be used to bias amplifiers and produce a fixed reference for sensor devices. The generation of a voltage reference is also important for voltage regulators. Currently, most reported organic integrated circuits use only p-type OFETs in their circuits due to simpler fabrication procedures. Furthermore, air stable p-type organic semiconductors such as pentacene and CuPc are well characterized. In this paper, a low power two stage all PMOS voltage reference generator is proposed. Since properties such as threshold voltage value and device aging are dependent on the OFET structure, the type of device chosen for this purpose will have a direct impact on the circuit performance. Three different types of OFETs with silver, copper, and gold drain/source electrodes are studied in this work. Performance factors such as line sensitivity (LS), temperature coefficient (TC), power consumption, time constant, and output drifts of the fabricated integrated circuits are measured and reported to verify the characteristics of the proposed circuits. It is shown that the drain/source metal choice affects the threshold voltage dependent output potential of the reference generators.
Generation of a 3D model of the inside volume of shoes for e-commerce applications using industrial x-ray computed tomography
Authors: Wittmann J , Herl G , Hiller J 
Published: December 2021

Abstract
In 2018, 47% of global internet users had purchased footwear products through the internet, making it the second most popular online shopping category worldwide right after clothing with 57%. In the same year, on average, about every sixth parcel delivered in Germany (16.3%) was returned. With the effort and costs that are associated with the return of shoes, the objective of reducing the number of returns for shoes promises an enormous economic potential and helps to reduce the CO2 emissions due to a lower traffic volume. This paper presents a workflow for determining the inside volume surface of shoes using industrial x-ray computed tomography (CT). The fundamental idea is based on the Region Growing (RG) method for the segmentation of the shoe’s inner volume. Experiments are performed to illustrate the correlation of image quality and segmentation result. After obtaining the 3D surface model of an individual foot, the inner volume surface data of a scanned shoe can then be registered and evaluated in order to provide a reliable feedback for the customer regarding the accuracy of fit of a shoe and the individual foot on the basis of an overall ‘metric of comfort’ before buying online. This step is not part of the work at hand. Conclusions are drawn and suggestions for improving the robustness and the flexibility of the workflow are given, so it can be adapted to various shoe types and implemented in a fully automated measurement process in the future.
Gene set analysis with graph-embedded kernel association test
Authors: Qu Jialin , Cui Yuehua 
Published: December 2021

Abstract

Motivation
Kernel-based association test (KAT) has been a popular approach to evaluate the association of expressions of a gene set (e.g. pathway) with a phenotypic trait. KATs rely on kernel functions which capture the sample similarity across multiple features, to capture potential linear or non-linear relationship among features in a gene set. When calculating the kernel functions, no network graphical information about the features is considered. While genes in a functional group (e.g. a pathway) are not independent in general due to regulatory interactions, incorporating regulatory network (or graph) information can potentially increase the power of KAT. In this work, we propose a graph-embedded kernel association test, termed gKAT. gKAT incorporates prior pathway knowledge when constructing a kernel function into hypothesis testing.

Results
We apply a diffusion kernel to capture any graph structures in a gene set, then incorporate such information to build a kernel function for further association test. We illustrate the geometric meaning of the approach. Through extensive simulation studies, we show that the proposed gKAT algorithm can improve testing power compared to the one without considering graph structures. Application to a real dataset further demonstrate the utility of the method.

Availability and implementation
The R code used for the analysis can be accessed at https://github.com/JialinQu/gKAT.

Supplementary information
Supplementary data are available at Bioinformatics online.
geoCancerPrognosticDatasetsRetriever: a bioinformatics tool to easily identify cancer prognostic datasets on Gene Expression Omnibus (GEO)
Authors: Alameer Abbas , Chicco Davide 
Published: December 2021

AbstractSummaryHaving multiple datasets is a key aspect of robust bioinformatics analyses, because it allows researchers to find possible confirmation of the discoveries made on multiple cohorts. For this purpose, Gene Expression Omnibus (GEO) can be a useful database, since it provides hundreds of thousands of microarray gene expression datasets freely available for download and usage. Despite this large availability, collecting prognostic datasets of a specific cancer type from GEO can be a long, time-consuming and energy-consuming activity for any bioinformatician, who needs to execute it manually by first performing a search on the GEO website and then by checking all the datasets found one by one. To solve this problem, we present here geoCancerPrognosticDatasetsRetriever, a Perl 5 application which reads a cancer type and a list of microarray platforms, searches for prognostic gene expression datasets of that cancer type and based on those platforms available on GEO, and returns the GEO accession codes of those datasets, if found. Our bioinformatics tool can easily generate in a few minutes a list of cancer prognostic datasets that otherwise would require numerous hours of manual work to any bioinformatician. geoCancerPrognosticDatasetsRetriever can handily retrieve multiple prognostic datasets of gene expression of any cancer type, laying the foundations for numerous bioinformatics studies and meta-analyses that can have a strong impact on oncology research.Availability and implementationgeoCancerPrognosticDatasetsRetriever is freely available under the GPLv2 license on the Comprehensive Perl Archive Network (CPAN) at https://metacpan.org/pod/App::geoCancerPrognosticDatasetsRetriever and on GitHub at https://github.com/AbbasAlameer/geoCancerPrognosticDatasetsRetriever.Supplementary informationSupplementary data are available at Bioinformatics online.
BioProfiling.jl: profiling biological perturbations with high-content imaging in single cells and heterogeneous populations
Authors: Vulliard Loan , Hancock Joel , Kamnev Anton , Fell Christopher W , Ferreira da Silva Joana , Loizou Joanna I , Nagy Vanja , Dupré Loïc , Menche Jörg 
Published: December 2021

AbstractMotivationHigh-content imaging screens provide a cost-effective and scalable way to assess cell states across diverse experimental conditions. The analysis of the acquired microscopy images involves assembling and curating raw cellular measurements into morphological profiles suitable for testing biological hypotheses. Despite being a critical step, general-purpose and adaptable tools for morphological profiling are lacking and no solution is available for the high-performance Julia programming language.ResultsHere, we introduce BioProfiling.jl, an efficient end-to-end solution for compiling and filtering informative morphological profiles in Julia. The package contains all the necessary data structures to curate morphological measurements and helper functions to transform, normalize and visualize profiles. Robust statistical distances and permutation tests enable quantification of the significance of the observed changes despite the high fraction of outliers inherent to high-content screens. This package also simplifies visual artifact diagnostics, thus streamlining a bottleneck of morphological analyses. We showcase the features of the package by analyzing a chemical imaging screen, in which the morphological profiles prove to be informative about the compounds' mechanisms of action and can be conveniently integrated with the network localization of molecular targets.Availability and implementationThe Julia package is available on GitHub: https://github.com/menchelab/BioProfiling.jl. We also provide Jupyter notebooks reproducing our analyses: https://github.com/menchelab/BioProfilingNotebooks. The data underlying this article are available from FigShare, at https://doi.org/10.6084/m9.figshare.14784678.v2.Supplementary informationSupplementary data are available at Bioinformatics online.
V-OG05 Robotic Hellers Myotomy
Authors: Knight Ben 
Published: December 2021

Abstract

Background
Achalasia is a rare condition affecting less than 1:100,000 patients. Treatment for this rare condition include balloon dilation, botox injection, endoscopic myotomy (POEMS) or surgical myotomy. Laparoscopic surgical myotomy is the “go to” approach for most surgeons; it is tried and tested, can be performed safely and quickly with a low complication rate, minimal pain and a short length of stay.

Methods
This video presents the technique adopted for robotic oesophageal myotomy in a patient with type II achalasia. A 4 arm technique was adopted with arm 4 on the patients left. The Davinci X system was used in this case. A Nathensen liver retractor was used to retract the liver; robotic instruments included the hook and cadiere forceps x2.

Results
The procedure was successfully performed; the operative time was 53 minutes, LOS was &lt;24 hours. Check endoscopy revealed a wide open gastro-oesophageal junction and a long myotomy. The patient noted an improvement in symptoms with 24 hours and has had no significant reflux.

Conclusion
The enhanced magnified 3D view on the robotic platform allows better visualisation of the hiatal structures, vagal nerves and muscle fibres when performing the myotomy. Using the 4th arm to retract the lateral edge of the oesophageal muscle provides a very safe and stable platform to perform a long myotomy. I think the robotic system should be adopted as the standard approach for a hellers myotomy.
O-B03 Bariatric Surgery in Patients Awaiting a Kidney Transplant - Systematic Review and Personal Experience from a High Volume Bariatric Centre
Authors: Hamaoui Karim , Russell Neil , Al-Rashedy Mohammed , Al-Taan Omer 
Published: December 2021

Abstract

Background
Morbid obesity in end stage renal disease (ESRD) is a barrier to kidney transplantation due to potential suboptimal post-transplant outcomes. Bariatric surgery is the most effective treatment for morbid obesity and has been shown to improve transplant eligibility through weight loss. There is no national UK guidance with regards to the role of bariatric surgery in patients requiring a kidney transplant. We present a decade of experience from a large NHS tertiary referral bariatric centre of performing bariatric surgery for weight loss in a cohort of high BMI ESRD patients.

Methods
A retrospective review was conducted of all patients undergoing bariatric surgery between 2007-2017. All patients with chronic kidney disease (CKD) at the time of bariatric surgery were identified. Patient records for those with CKD stage 4 and Stage 5 (or ESRD) were reviewed and data extracted for analysis. A systematic review was also conducted of reported experiences of bariatric surgery in CKD patients as a bridge to kidney transplantation.

Results
Of 3119 patients operated on in the identified period 22 were identified as having CKD at the time of surgery. Sleeve gastrectomy was the most commonly performed procedure. There was no recorded post-operative complications or 30-day mortalities. Median LOS was 4 days (range:2-6), pre-operative BMI 45 (Range:37-69), 12m post-op excess weight loss 17.3±14.4%, final EWL 22.3±14.8% at 32 months follow-up (Range: 6-52). 57% were subsequently transplant wait listed, 28% proceeded to transplantation 18.5months after listing (Range:7-30months). Systematic review of 15 studies suggests bariatric surgery in these patients is safe and facilitates 1/4 of patients being listed and transplanted.

Conclusions
Experience from a large UK NHS bariatric centre shows weight-loss surgery in high BMI patients with CKD4/5 is safe, with minimal peri-operative morbidity and mortality. 1 in 2 patients proceeded to being listed for transplantation, and 1 in 3 progressed to transplantation. We should consider formalising the role of bariatric surgery in the pre-listing workup of high BMI ESRD patients in the UK to give all patients equal chances for transplantation.
O-B05 Does rapid or gradual weight loss following bariatric surgery affect lean body mass depreciation?
Authors: Sivakumar Jonathan , Chen Qianyu , Read Matthew , Sutherland Tom , Ward Salena , Chong Lynn , Hii Michael 
Published: December 2021

Abstract

Background
Controversy exists regarding the influence of the rate of weight loss on long-term body composition. The objective of this study was to compare body composition changes in patients with successful and unsuccessful weight loss 12 months after bariatric surgery.

Methods
A prospective analysis was completed on patients undergoing bariatric surgery at St Vincent’s Hospital Melbourne between 2017 and 2021. Body composition was measured with dual-energy X-ray absorptiometry immediately before surgery, and at 12 months post-operatively. Fat mass (FM), lean body mass (LBM) and skeletal muscle index (SMI) trajectories were analysed between patients, with either successful weight loss (SWL) or unsuccessful weight loss (USWL) stratified based on an excess weight loss (EWL) threshold of ≥ 50%.

Results
Thirty-seven patients were included in this series (SWL n = 25, USWL n = 12). Compared to those with USWL, SWL demonstrated a greater mean loss in BMI (12.3 vs 7.3 kg/m2; p &lt; 0.001) and weight (34.4 vs 20.3 kg; p &lt; 0.001). SWL demonstrated a significantly greater reduction in tissue fat% than USWL, with patients losing 7.3% more tissue fat on average. SWL was associated with an improved mean SMI% when compared with USWL (5.5 vs. 2.42%; p &lt; 0.0009). However, the difference in FM:LBM loss ratio between the two groups did not demonstrate statistical significance (7.07 vs 4.62, p = 0.2519).

Conclusions
This data suggests that SWL is associated with a more optimal body composition outcome than USWL, which is at least partly due to a relative skeletal muscle-sparing effect in this group. Further research is warranted in understanding the implications of these changes on resting energy expenditure and the risk of weight regain.
O-L03 Safety and Efficacy of Endoscopic Retrograde Cholangiopancreatography for Removal of Common Bile Duct Stones in the Nonagenarians: A Single Tertiary Centre Experience
Authors: Ijaz Sijjad , Khan Amaan , Gariballa Mohammed , Jalal Mustafa , Al-Joudeh Yasser Amer 
Published: December 2021

Abstract

Background
It is estimated that one in four persons in the UK will be &gt; 65 years old by 2050. Endoscopic retrograde cholangiopancreatography (ERCP) is the recommended therapy for removals of common bile duct (CBD) stones. There is a lack of UK data on the outcome of ERCP in the very elderly. We aimed to investigate the safety and efficacy of ERCP in the management of CBD stones in the elderly &gt;90 years old compared with those aged 65-89 years old.

Methods
We retrospectively analysed patients undergone ERCP between 2016-2020. Those with conditions other than suspected CBD stones were excluded. The following data was collected: general demographics, comorbidities, American Association of Anaesthesiology (ASA) grading, presence of dementia, anticoagulation therapy, endoscopic report on completed intention of treatment which is defined by either removal of stone and/or stent insertion. Also, post-procedure complications were collected including post-ERCP pancreatitis (PEP), bleeding, perforation, cholangitis, respiratory, and cardiovascular (CVS) events. Readmission within 7 days and death within 30 days were collected. Outcomes were reported as mean ± (SD) or n (%). Statistical significance was considered when P &lt; 0.05.

Results
Total, 126 patients ≥ 90 years(group A) compared to 262 patients aged 65-89 years(group B). Higher rate of dementia, and anticoagulation therapy in Group A (17.4%) vs (0.4%),p &lt;0.0001 and (36.5%) vs (17.9%),p &lt;0.0001,respectively. Completed treatment was achieved in group A(90.5%) compared to group B(89.9%),p 0.7. One patient (0.8%) had PEP group A compared to 8(3.1%) group B,p 0.3. Overall complications (13.5%) group A vs (9.5%) group B,p 0.3. Four cases (3.2%) died within 30-day in group A compared to group B 5 (1.9%), p 0.5. There was no procedure-related death

Conclusions
ERCP for removal of CBD stones in &gt; 90 years old is effective. Risk of post-ERCP pancreatitis and overall adverse events were not higher in the &gt; 90 years compared to 65-89 years old. We report a 30-day mortality rate of 3.2%. The most common cause of death was pneumonia including COVID-19 peumonia.
P-B02 Does the length of alimentary limb make a significant difference in the weight loss in Roux en y gastric bypass patients?
Authors: Bhandari Mayank , Chowdhary Sabyasachi , Rao Milind , Bussa Gopinath , Holm Julie 
Published: December 2021

Abstract

Background
Roux en Y gastric bypass (RYGB) surgery for morbid obesity is considered as gold standard, but there can be a difference in the length of alimentary and biliopancreatic limb to achieve optimum weight loss. Till now there is no agreed consensus on the ideal limb lengths and their effect on the weight loss. We would like to evaluate the change in the alimentary limb length on the weight loss after the gastric bypass surgery, as a short to medium term single center study.

Methods
A retrospective analysis from prospectively maintained database of 523 patients who underwent RYGB from 2012 till 2018 was done. Patient who had at least a follow up of 2 years(n = 388) were included. At our center we use alimentary limb of 120 +/- 10 cm for Body Mass Index (BMI) &lt; 40 kg/m2 (group A) and 150+/-10 cm for the BMI &gt;40 kg/m2 (Group B). The biliopancreatic limb length varies from 50 to 70 cm and this does not change with BMI. The percentage excess weight(EWL) loss was measured and analyzed at 1st and 2nd year post operatively. We used paired t test to check for statistical significance.

Results
There were 172 patients in Group A and 216 in Group B. The number of females were 330 and males were 58. The average age was 44 years . The mean preoperative BMI for the 120 cm limb group was 37.1 kg/m2 and that for 150 cm limb was 45.3kg/m2. The EWL for the group A at 1 year and 2 year post op was a Mean and standard deviation of 79.3% +/- 39.4% and 78.3% +/- 35.2% respectively and for group B was 58.8% +/- 26.6% and 58.6% +/- 23.2% respectively. The difference was statistically significant (p &lt; 0.001) . The analysis and interpretation for metabolic syndrome is yet to be determined.

Conclusions
In our study, Increasing the alimentary limb length for higher BMI reduced EWL. This is consistent with few other publications regarding the same. This has resulted in a change in our practice namely keeping the length of alimentary limb constant and varying the BP limb length. We will be analyzing and presenting this data in future.