bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new aphelench nematode, Basilaphelenchus brevistylus n. sp. (Aphelenchoididae: Tylaphelenchinae) from Pinus massoniana in China
Authors: Akol Bashiy , Huang Qiuling , Lin Borong , Wang Honghong , Liao Jinling , Zhuo Kan 
Published: September 2021

Abstract

Basilaphelenchus brevistylus n. sp. was isolated from masson pine (Pinus massoniana) in Guangdong province, China. The new species is characterized by an offset lip region, short stylet (female stylet 4.5-5.5 μm and male stylet 4-5 μm long) with three elongate posteriorly directed knobs, posteriorly located metacorpal valve and lateral field composed of three lines. The female has an elongate postuterine sac and a short conical tail, uniformly narrowing toward a sharp tip, or tapering to a slightly offset mucronate tip in a few individuals. The male has a conical tail with a sharp terminal mucro, three pairs of caudal papillae, and small arcuate spicules with a bluntly rounded condylus and small pointed rostrum. B. brevistylus n. sp. can be distinguished from all described Basilaphelenchus nematodes by numerous morphological and morphometrical traits, especially the tail morphology of both sexes and stylet length. In addition, molecular phylogenetic trees inferred from rRNA small subunit and D2-D3 expansion domains of large subunit revealed that this nematode belongs to the Basilaphelenchus, and is clearly different from all the other Basilaphelsenchus species.
Protective Effect of Algerian Genista vepres Pomel Plant Against Isoniazid
and Rifampicin Induced Liver Injury in Wistar Albino Rats
Authors: Zehani Lamia , Kerkatou Wafa , Hamdouche Souad , Lassed Somia , Boumaza Ouahiba , Benayache Fadila , Benayache Samir , Zama Djamila 
Published: September 2021

Background:
The aim of the present study is to evaluate the protective effect of n-
BuOH fraction of Genista vepres Pomel and Vitamin E against Isoniazid and Rifampicin (INH-
RIF)-induced liver injury.

Methods:
Male Wistar Albino rats were divided into eight equal groups treated with plant fraction
(50 mg/kg, 100 mg/kg), vitamin E (100 mg/kg) and INH-RIF (100 mg/kg body weight /day each).
At the end of the experiment, animals were dissected and samples (blood, liver tissue) were removed
and isolated for biochemical and histological studies.

Results :
Administration of INH-RIF for 21 days resulted in hepatic failure as evidenced by the elevation
of biochemical parameters levels and hepatic oxidative stress, which was associated with extensive
hepatic parenchyma alteration. The pretreatment of the rat with G. vepres Pomel attenuated
the increase of hepatic dysfunction markers, significantly decreased the level of malondialdehyde
(MDA), and increased GSH level, GPx and catalase activities compared to INH-RIF treated group.
However, the Vitamin E co-treatment decreased MDA level and increased GPx activity but did not
show any effect on catalase or GSH parameters. The histopathological studies on the liver of rats also
supported that both plant fraction and vitamin E markedly reduced the toxicity of INH-RIF and
preserved the histoarchitecture of liver tissue.

Conclusion:
The results suggested that the n-BuOH fraction of G. vepres Pomel acts as a potent hepatoprotective
agent against INH-RIF-induced Hepatic dysfunction in rats.
Design, Synthesis, Docking, Characterization and Biological Screening of Novel Azetidinone Derivatives of Nicotinic Acid
Authors: Sivaperuman Amuthalakshmi , Natarajan Ramalakshmi , Subramani Arunkumar , Angamuthu Prabakaran 
Published: September 2021

Background:The prevailing multiple drug resistance among the bacterial species is alarmingly rising day to day, becoming a global threat. Many infectious diseases have become untreated due to the development of resistance in bacterial species, which have a considerable impact on mortality.Methods:In this present study, we aimed to synthesize a series of 12 compounds [S1-S12], which are azetidinone derivatives of nicotinic acid. The in vitro antibacterial studies were performed against certain species of gram-negative and gram-positive bacteria. Molecular docking studies were performed to identify the affinity towards the target protein. The antioxidant study was also performed for the synthesized compounds.Results:All the synthesized compounds exhibited moderate to potent antibacterial activity with a MIC range of 9.8-21.6 μgmL-1, compounds were active against all tested micro-organisms. The compounds substituted with electron-donating groups like hydroxyl showed higher antioxidant activity compared to others. Docking studies were performed on the active site of DNA gyrase [PDBID: 5L3J,2XCT, 1W7Q].Conclusion:The present study reveals that the compounds synthesized exhibit very good antimicrobial activity and antioxidant activity. Therefore, these compounds may be used as a lead for the anticancer, anti-tubercular and other chemotherapeutic agents in future studies.
Implementation of an Electronic Patient-Reported Outcome App for Health-Related Quality of Life in Breast Cancer Patients: Evaluation and Acceptability Analysis in a Two-Center Prospective Trial
Authors: Graf Joachim , Sickenberger Nina , Brusniak Katharina , Matthies Lina Maria , Deutsch Thomas M , Simoes Elisabeth , Plappert Claudia , Keilmann Lucia , Hartkopf Andreas , Walter Christina Barbara , Hahn Markus , Engler Tobias , Wallwiener Stephanie , Schuetz Florian , Fasching Peter A , Schneeweiss Andreas , Brucker Sara Yvonne , Wallwiener Markus 
Published: September 2021

Background
One in eight women is diagnosed with breast cancer in the course of their life. As systematic palliative treatment has only a limited effect on survival rates, the concept of health-related quality of life (HRQoL) was developed for measurement of patient-centered outcomes. Various studies have already demonstrated the reliability of paper-based patient-reported outcome (pPRO) and electronic patient-reported outcome (ePRO) surveys and that the 2 means of assessment are equally valid.

Objective
The aim of this study was to analyze the acceptance and evaluation of a tablet-based ePRO app for breast cancer patients and to examine its suitability, effort, and difficulty in the context of HRQoL and sociodemographic factors.

Methods
Overall, 106 women with adjuvant or advanced breast cancer were included in a 2-center study at 2 major university hospitals in Germany. Patients were asked to answer HRQoL and PRO questionnaires both on a tablet on-site using a specific eHealth assessment website and on paper. The suitability, effort, and difficulty of the app and self-reported technical skills were also assessed. Only the results of the electronically acquired data are presented here. The results of the reliability of the pPRO data have already been published elsewhere.

Results
Patients regarded the ePRO assessment as more suitable (80/106, 75.5%), less stressful (73/106, 68.9%), and less difficult (69/106, 65.1%) than pPRO. The majority of patients stated that ePRO assessment improves health care in hospitals (87/106, 82.1%). However, evaluation of ePROs depended on the level of education (P=.003) in the dimensions of effort and difficulty (regression analysis). The app was rated highly in all categories. HRQoL data and therapy setting did not show significant correlations with the app’s evaluation parameters.

Conclusions
The results indicate that ePRO surveys are feasible for measuring HRQoL in breast cancer patients and that those patients prefer ePRO assessment to pPRO assessment. It can also be seen that patients consider ePRO assessment to improve hospital health care. However, studies with larger numbers of patients are needed to develop apps that address the needs of patients with lower levels of education and technical skills.
A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study
Authors: Shahzadi Syeda Kiran , Karuvantevida Noushad , Banerjee Yajnavalka 
Published: September 2021

Background
Cancer is the third leading cause of death in the United Arab Emirates (UAE), after cardiovascular diseases and accidents. In the UAE, colorectal cancer (CRC) is the first and fourth most common cancer in males and females, respectively. Several treatment modalities have been employed for cancer treatment, such as surgery, radiotherapy, chemotherapy, hormone replacement therapy, and immunotherapy. These treatment modalities often elicit adverse effects on normal cells, causing toxic side effects. To circumvent these toxicities, there has been an increased impetus towards the identification of alternate treatment strategies. Animal venoms are rich sources of pharmacologically active polypeptides and proteins.

Objective
In this proof-of-concept study, we will apply a high-throughput venomics strategy to identify and characterize anticancer bioactive peptides (BAPs) from 20 different animal venoms, specifically targeting CRC. We chose to focus on CRC because it is one of the foremost health issues in the UAE.

Methods
In the initial study, we will screen 2500 different peptides derived from 20 different animal venoms for anticancer activity specifically directed against 3 CRC cell lines and two control cell lines employing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay for cytotoxicity. Of the 20 venoms, 3 that exhibit specific and potent anticancer activity directed against the 3 CRC cell lines will be selected; and from these 3 venoms, the specific peptides with anti-CRC activity will be isolated and characterized.

Results
This study is at the protocol development stage only, and as such, no results are available. However, we have initiated the groundwork required to disseminate the proposed study, which includes culturing of colorectal cancer cell lines and preparation of venom screens.

Conclusions
In summary, the proposed study will generate therapeutic leads to manage and treat one of the leading health issues in the UAE, namely, CRC.

International Registered Report Identifier (IRRID)
PRR1-10.2196/31128
PELATIHAN PEMBUATAN KERIPIK PISANG DAN OPAK MINI PELANGI: INOVASI PRODUK PEMANFAATAN HASIL KEBUN DI DESA MEKAR SARI
Authors: Basri Muhammad , Insani Marzius , Hermawan Roni , Saputri Wulan , Karuniawati Mei , Rahayu Rani , Dewi Nurul Aulia , As’ari Roifan Akib , Pradani Windy , Ramadhani Ardelia Putri 
Published: September 2021

Kurangnya minat masyarakat dalam mengolah pemanfaatan hasil kebun, yaitu buah pisang dan singkong di Desa Mekar Sari menunjukkan belum adanya inovasi baru dalam pemanfaatan hasil kebun. Padahal seharusnya bisa menjadi makanan khas desa dan meningkatkan perekonomian masyarakat. Namun, masyarakat Desa Mekar Sari hanya menjual hasil kebun secara langsung kepada para tengkulak tanpa mengolahnya terlebih dahulu menjadi sebuah produk. Hasil kebun seperti pisang dan singkong dapat diolah menjadi sebuah produk seperti keripik dan opak mini pelangi. Inovasi yang dapat dilakukan untuk produk keripik yaitu dari segi bentuk serta rasa yang berbeda dari biasanya. Sedangkan singkong yang di olah menjadi sebuah opak mini diinovasikan dengan berbagai warna. Kegiatan ini bertujuan untuk menghasilkan sebuah inovasi makanan yang bisa dijadikan makanan khas Desa Mekar Sari serta meningkatkan perekonomian masyarakat. Metode yang digunakan dalam kegiatan ini ada 2, yatitu edukasi dan pengembangan serta pengolahan dengan jumlah peserta 20 orang karena masih dalam masa pandemi. Hasil yang diperoleh yaitu masyakat mampu membuat produk keripik pisang dan opak mini pelangi untuk membantu meningkatkan perekonomian.
Pengaruh Pertumbuhan Ekonomi, PAD, DAU Terhadap Pengalokasian Anggaran Belanja Modal Pada Kabupaten/Kota Sumatera Selatan
Authors: Aryani Putri Retno , Hari Kurnia Krisna 
Published: September 2021

This research is aimed at determining the influence ofeconomic growth, local revenue and general fund allocation toward appropriation of capital budget In Districts/City in South Sumatera Province. The samples used in this study were 11 districts/cities in South Sumatera Province in line with the source of Realization Report Budget (APBD) which was accessed from www.djpk.depkeu.go.id and Economic Growth which was obtained from the Central Statistics Agency of South Sumatera Province. The data used in this research was secondary data. The technique of analyzing the data was using multiple regression test.
Simulataneously, the results showed that Economic Growth, Local Revenue and General Fund Allocation had positive significant influence toward capital expenditures. While, partially, the results showed that Economic Growth had no positive significant influence toward toward Capital Expenditure, regional revenue had no positive significant influence toward Capital Expenditure, General Fund Allocation had positive significant toward Capital Expenditure.
THE EFFECT OF PROFITABILITY AND GOOD CORPORATE GOVERNANCE ON EARNINGS QUALITY
Authors: Aprilian Rani , Andi Kiagus , Amelia Yunia 
Published: September 2021

This study aims to examine the effect of profitability and good corporate governance on earnings quality in food and beverage companies listed on Indonesia Stock Exchange (IDX) 2015-2018 period. Profitability is calculated using Return on Assets (ROA). The proxy of Good Corporate Governance are institutional ownership, managerial ownership, audit committee, and independent commissioner. The dependent variable in this study is earnings quality measured by discretionary accrual using Modified Jones Model to detect earning management.
This study used secondary data from the official website of Indonesian Stock Exchange (www.idx.co.id) and the sampling method in this study uses purposive sampling method. The data analysis in this study using multiple linear regression analysis. The results of this study indicate that profitability and audit committee have a positive effect on earnings quality, while the independent commissioner has a negative effect on earnings quality. Other independent variables i.e. institutional ownership and managerial ownership have no significant effect on earnings quality
Model Kepemimpinan Transformasional dan Kontribusinya terhadap Proses Decision Making dan Peningkatan Kinerja Guru di MA Ar-Ridlo Pekuncen Kabupaten Banyumas
Authors: Assegaf Fatimah 
Published: September 2021

Abstract
Leadership is a competency that must be owned by madrasah principals. Decision making in educational organizations is directly related to the head of the madrasah. The principal of the madrasah as manager has an important role in making decisions quickly, precisely and effectively by using data and information for optimal educational environmental performance. Decision-making by the head of the MA Ar - Ridlo Pekuncen Banyumas has gone well, this can be seen from the processes and stages carried out by the head of the madrasah in making decisions with observation, data, planning and recording related to education in madrasahs. Then, conduct deliberations with teachers to take policies, take an interpersonal approach to teachers to hold events, give ideas, involve teachers in training, and supervise as supervisory activities. As stated in the teacher work assessment, this is useful for increasing the potential and performance of teachers, to improve the quality of teaching and learning outcomes at MA Ar - Ridlo Pekuncen Banyumas.
Keyword : Principal, Decision-Making, Teachers; Performance, Senior High School
Pengembangan Madrasah melalui Modal Sosial
Authors: Munif Fatkhan 
Published: September 2021

The purpose of this research is to describe the study of social capital as capital for madrasa in development of their institutions. Madrasa is an educational institution labeled as Islamic which initially did not immediately receive public attention. Many attempts have been made to obtain the legality of recognition of its existence. In addition, madrasa are educational institutions that have a close image with community contributions in the sense that madrasa cannot be separated from society. This contribution is an important asset for the survival and existence of madrasa. Madrasa in its development involves the community as the center of the progress of the institution. This community contribution is a social capital that can improve the quality of madrasa through their role and support. In the study of social capital, there are three main elements, namely trust, value and network. The three of them are related to each other and form a bond as an asset in developing madrasa. Madrasa and communities establish close relationships as a strategic step in improving the quality of educational institutions. Therefore it is necessary to have a harmonious relationship between madrasa and society so that common goals can be achieved.
Biomechanical evaluation of two dorsal and two ventral stabilization techniques for atlantoaxial joint instability in toy-breed dogs
Authors: Progin Alexia , Voumard Benjamin , Friker Brian , Forterre Franck 
Published: September 2021

Abstract

OBJECTIVE
To compare the biomechanical properties of atlantoaxial joints (AAJs) in canine vertebral column specimens stabilized with 4 techniques (dorsal wire, modified dorsal clamp, ventral transarticular pin, and augmented ventral transarticular pin fixation) after transection of the AAJ ligaments.

Sample
13 skull and cranial vertebral column segments from 13 cadaveric toy-breed dogs.

PROCEDURES
Vertebral column segments from the middle aspect of the skull to C5 were harvested and prepared; AAJ ligament and joint capsule integrity was preserved. The atlantooccipital joint and C2 to C5 vertebral column segments were fixed with 2 transarticular Kirschner wires each. The occipital bone and caudalmost aspect of each specimen were embedded in polymethylmethacrylate. Range of motion of the AAJ under shear loading conditions up to 15 N was determined for each specimen during the third of 3 loading cycles with intact ligaments, after ligament transection, and after stabilization with each technique in random order. For each specimen, a load-to-failure test was performed with the fixation type tested last.

RESULTS
All stabilization techniques except for dorsal clamp fixation were associated with significantly decreased AAJ range of motion, compared with results when ligaments were intact or transected. The AAJs with dorsal wire, ventral transarticular pin, and augmented ventral transarticular pin fixations had similar biomechanical properties.

CONCLUSIONS AND CLINICAL RELEVANCE
Dorsal wire, ventral transarticular pin, and augmented ventral transarticular pin fixation increased rigidity, compared with results for AAJs with intact ligaments and for AAJs with experimentally created instability. Additional studies are needed to assess long-term stability of AAJs stabilized with these techniques.
Comparison of urine fibrinogen and interleukin-6 concentrations between healthy dogs and dogs with risk factors for enterococcal bacteriuria
Authors: Lepold Adam M. , Tesfamichael Dahlia H. , Hartmann Faye A. , Wiley Claire A. , Wood Michael W. 
Published: September 2021

Abstract

OBJECTIVE
To compare urine concentrations of fibrinogen (uFIB) and interleukin-6 (uIL-6) between dogs with risk factors for enterococcal bacteriuria and healthy dogs.

SAMPLE
Banked urine samples with negative aerobic culture results from 8 dogs with urolithiasis, 9 dogs with anatomic abnormalities of the lower portion of the urinary tract (LUT), 10 dogs with LUT neoplasia, and 21 healthy control dogs.

PROCEDURES
Urine creatinine concentration (uCrea) was determined by an automated biochemical analyzer, and uFIB and uIL-6 were determined by dog-specific ELISAs. The uFIB:uCrea and uIL-6:uCrea ratios were calculated for each sample to normalize intersample differences in urine concentration and were compared among the 4 experimental groups.

RESULTS
Median uFIB:uCrea ratios for dogs with urolithiasis (0.72; interquartile [25th to 75 percentile] range [IQR], 0.46 to 3.48) and LUT neoplasia (6.16; IQR, 3.89 to 12.75), but not for dogs with LUT anatomic abnormalities (0.48; IQR, 0.27 to 0.69), were significantly greater than that for control dogs (0.17; IQR, 0.07 to 0.39). Median uIL-6:uCrea ratios for dogs with urolithiasis (0.48; IQR, 0.18 to 1.61), LUT anatomic abnormalities (0.25; IQR, 0.17 to 0.33), and LUT neoplasia (0.25; IQR, 0.12 to 1.01) were significantly greater than that for control dogs (0.08; IQR, 0.06 to 0.11).

CONCLUSIONS AND CLINICAL RELEVANCE
The uFIB and uIL-6 in dogs with risk factors for enterococcal bacteriuria were generally greater than corresponding values in control dogs. Further investigation is necessary to determine the role of fibrinogen in enterococcal colonization of the urinary tract of dogs.
IMPLIKASI PRINSIP RIGHT OF EXTERNAL SELF DETERMINATION TERHADAP KEDAULATAN NEGARA INDUK SEBAGAI SUBJEK HUKUM INTERNASIONAL
Authors: Rachman AA Muhammad Insany , Hastri Evi Dwi 
Published: September 2021

Tujuan penelitian ini dilakukan adalah untuk mengkaji dan menganalisis pelaksanaan prinsip right of external self determination yang pada dasarnya merupakan hak setiap orang yang tinggal dalam suatu wilayah untuk menentukan status kenegaraan, hukum dan politik wilayah itu sendiri. Dimana keberadaan prinsip tersebut bertolak belakang dalam hal menjaga kedaulatan teritorial sebuah negara. Metode penelitian yang digunakan berupa pendekatan yuridis-normatif, penelitian difokuskan untuk mengkaji penerapan kaidah, norma dan prinsip dalam hukum internasional. Teknik pengumpulan data dilakukan dengan cara studi kepustakaan, yakni melalui bahan hukum sekunder dan studi informasi yang bersumber dari internet. Adapun metode analisis data yang digunakan dalam penelitian ini adalah metode normatif kualitatif. Hasil penelitian menunjukkan intinya negara induk tersebut tetap berdaulat, hanya saja untuk tindakan tertentu harus sesuai dengan prinsip-prinsip hukum internasional yang ada. Negara yang turut serta bergaul dalam lingkup masyarakat internasional pada kenyataannya pasti terdapat keinginan atau kepentingan yang diharapkan, maka untuk mencapai hal tersebut ada hal yang perlu dipertaruhkan yaitu sebagian kekuasaan atau sebagian kedaulatan negaranya harus tunduk pada prinsip-prinsip hukum internasional. Namun untuk pilihan pemisahan sebagian wilayah tersebut merupakan opsi yang terakhir yang bisa dilakukan dengan memenuhi persyaratan dan keadaan yang ada.
ANALISIS TINGKAT KEPUASAN PELANGGAN TERHADAP KUALITAS PELAYANAN BUS RAPID TRANSIT,SURABAYA (Studi Kasus: Pelayanan Suroboyo Bus)
Authors: Firdaus Royyan , Wahyuni Atik , Tistogondo Julistyana 
Published: September 2021

Suroboyo Bus merupakan jenis bus yang berbasis Bus Rapid Transit. Transportasi umum ini adalah transportasi baru yang dikeluarkan oleh Pemerintah Kota Surabaya dengan berbagai jalur di tengah Kota. Rute yang baru dibuka yaitu di rute MERR-Gunung Anyar. Oleh karena itu, penelitian dilakukan untuk mengetahui penilaian dari pelanggan terhadap kualitas pelayanan Suroboyo Bus. Dalam penelitian ini, variabel independennya menggunakan metode SERVQUAL (Service Quality) yang memiliki lima dimensi penting yaitu Tangible (X1), Assurance (X2), Reliability (X3), Responsiveness (X4), dan Empathy (X5). Sedangkan variabel dependennya adalah Kualitas Infrastruktur Pelayanan (Y). jumlah sampel sebanyak 100 responden dengan menggunakan analisis regresi linier berganda dan metode importance performance analysis (IPA). Kelima variabel independen berpengaruh signifikan terhadap variabel dependen secara simultan dan ada beberapa variabel independen yang berpengaruh secara parsial. Berdasarkan hasil penelitian, kinerja pelayanan yang diberikan belum memenuhi harapan pelanggan/penumpang. Tetapi pelangaan merasa bahwa pelayanan yang diberikan sudah cukup memuaskan. Serta terdapat beberapa infrastruktur yang harus diprioritaskan untuk diperbaiki yaitu penambahan bangunan halte beserta infrastrukturnya, dan ketanggapan petugas guna meningkatkan tingkat kepuasan pelanggan dan kualitas pelayanan.

Kata kunci: Kepuasan Pelanggan, Pelayanan BRT, Suroboyo Bus, Importance-Performance Analysis (IPA).