bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-WorldClinical Outcomes in Patients with Locally Advanced or Metastatic Merkel Cell Carcinoma Treated in U.S. Oncology Clinical Practices: Results fromSPEAR-Merkel
Authors: Bhanegaonkar Abhijeet , Liu Frank X. , Boyd Marley , Fulcher Nicole , Kim Ruth , Krulewicz Stan , Smith Jodi , Cowey C. Lance 
Published: June 2021

AbstractBackgroundImmunotherapy (IO) has been associated with improved outcomes in patients with locally advanced Merkel cell carcinoma (laMCC) and metastatic Merkel cell carcinoma (mMCC). The primary objective of SPEAR-Merkel was to explore treatment patterns, clinical outcomes, and health care resource utilization (HCRU) in patients with laMCC or mMCC initiating first-line (1L) treatment with avelumab, non-avelumab IO, or chemotherapy in a U.S. community oncology setting.MethodsAdult patients with laMCC or mMCC initiating 1L avelumab, non-avelumab IO, or chemotherapy from January 1, 2015, to March 31, 2019, were identified from the U.S. Oncology Network electronic health care record database and followed up through September 30, 2019. Baseline characteristics and HCRU were analyzed descriptively, including physician-stated overall response rate in the real-world clinical setting. Kaplan-Meier methods were used to measure duration of response, real-world progression-free survival (rwPFS), and overall survival (OS).ResultsAmong the overall population (n = 94), 28 received 1L avelumab (9 laMCC, 19 mMCC), 26 received 1L non-avelumab IO (8 laMCC, 18 mMCC), and 40 received 1L chemotherapy (10 laMCC, 30 mMCC). The real-world overall response rate was 64.3%, 61.5%, and 42.5%, respectively. From 1L treatment initiation, median rwPFS was 11.4, 8.1, and 6.1 months, and median OS was 20.2 months, not reached, and 14.7 months for the respective cohorts.ConclusionSPEAR-Merkel showed that patients with laMCC or mMCC treated with IO had improved outcomes compared with chemotherapy in clinical practice. The study provides insight on utilization and clinical outcomes associated with newer, more innovative therapies in clinical practice, which may help clinicians understand the variety of newer treatment options for both laMCC and mMCC.Implications for PracticeTo the authors’ knowledge, SPEAR-Merkel is the first study to evaluate real-world clinical outcomes in patients with locally advanced Merkel cell carcinoma (laMCC) and metastatic Merkel cell carcinoma (mMCC) receiving first-line (1L) avelumab, non-avelumab immuno-oncology therapies, or chemotherapy in a real-world setting. SPEAR-Merkel showed clinical benefit for immuno-oncology therapies compared with chemotherapy. The study provides insight on uses and clinical outcomes associated with innovative therapies in clinical practice, which may help clinicians understand the variety of newer treatment options for both laMCC and mMCC. The study is of particular importance as it shows that chemotherapy is still being used as 1L treatment despite its inferior clinical and safety profile.
Monolingual and Bilingual Reading Processes in Russian: An Exploratory Scanpath Analysis
Authors: Parshina Olga , Sekerina Irina A. , Lopukhina Anastasiya , von der Malsburg Titus 
Published: June 2021

ABSTRACTIn the present study, we used a scanpath approach to investigate reading processes and factors that can shape them in monolingual Russian‐speaking adults, 8‐year‐old children, and bilingual Russian‐speaking readers. We found that monolingual adults’ eye movement patterns exhibited a fluent scanpath reading process, representing effortless processing of the written material: They read straight from left to right at a fast pace, skipped words, and regressed rarely. Both high‐proficiency heritage‐language speakers’ and second graders’ eye movement patterns exhibited an intermediate scanpath reading process, characterized by a slower pace, longer fixations, an absence of word skipping, and short regressive saccades. Second‐language learners and low‐proficiency heritage‐language speakers exhibited a beginner reading process that involved the slowest pace, even longer fixations, no word skipping, and frequent rereading of the whole sentence and of particular words. We suggest that unlike intermediate readers who use the respective process to resolve local processing difficulties (e.g., word recognition failure), beginner readers, in addition, experience global‐level challenges in semantic and morphosyntactic information integration. Proficiency in Russian for heritage‐language speakers and comprehension scores for second‐language learners were the only individual difference factors predictive of the scanpath reading process adopted by bilingual speakers. Overall, the scanpath analysis revealed qualitative differences in scanpath reading processes among various groups of readers and thus adds a qualitative dimension to the conventional quantitative evaluation of word‐level eye‐tracking measures.
Nachhaltige Stadtentwicklung und die Agenda 2030
Authors: Koch Florian , Krellenberg Kerstin 
Published: June 2021

ZusammenfassungIn Kap. 2 wurden die Grundsätze der Agenda 2030 und die Rolle der Städte bei deren Umsetzung aufgezeigt. In diesem Kapitel wird nun speziell auf die nachhaltige Stadtentwicklung und den Stand der Umsetzung der SDGs auf städtischer Ebene eingegangen.
Axion strings are superconducting
Authors: Fukuda Hajime , Manohar Aneesh V. , Murayama Hitoshi , Telem Ofri 
Published: June 2021

Abstract
We explore the cosmological consequences of the superconductivity of QCD axion strings. Axion strings can support a sizeable chiral electric current and charge density, which alters their early universe dynamics. We examine the possibility that shrinking axion string loops can become effectively stable remnants called vortons, supported by the repulsive electromagnetic force of the string current. We find that vortons in our scenario are generically unstable, and so do not pose a cosmological difficulty. Furthermore, if a primordial magnetic field (PMF) exists in the early universe, a large current is induced on axion strings, creating a significant drag force from interactions with the surrounding plasma. As a result, the strings are slowed down, which leads to an orders of magnitude enhancement in the number of strings per Hubble volume. Finally, we study potential implications for the QCD axion relic abundance. The QCD axion window is shifted by orders of magnitude in some parts of our parameter space.
Globale Mundgesundheit im internationalen gesundheitspolitischen Rampenlicht – Herausforderungen und neue Chancen für nachhaltige Verbesserungen
Authors: Benzian Habib , Listl Stefan 
Published: June 2021

ZusammenfassungOrale Erkrankungen sind ein signifikantes globales Gesundheitsproblem über alle Länder und Bevölkerungsgruppen hinweg. Mit fast 3,5 Mrd. Erkrankungsfällen (2017) sind so viele Menschen betroffen wie von keiner anderen Krankheitsgruppe. Die Haupterkrankungen sind unbehandelte Karies der bleibenden oder der Milchzähne, fortgeschrittene Parodontopathien, Zahnlosigkeit sowie Karzinome der Mundhöhle und Lippen. Bei weitgehend unverändert hoher globaler Prävalenz erhöhen durch Bevölkerungswachstum bedingte stark steigende Fallzahlen den Druck auf schwache oder überlastete Gesundheitssysteme, insbesondere in Ländern der unteren und mittleren Einkommensgruppen.Dennoch wird der Mundgesundheit in vielen Ländern nur unzureichende Priorität eingeräumt und sie erhält als wichtiges Thema im gesundheitspolitischen Diskurs der deutschen und globalen Akteure nach wie vor wenig Aufmerksamkeit. Eine der fundamentalen Herausforderungen ist dabei die Gewährleistung eines allgemeinen und fairen Zugangs zu adäquater universeller Basisgesundheitsversorgung für alle Menschen ohne Verursachung von finanziellen Härten (Universal Health Coverage).Dieser Beitrag gibt einen einführenden Überblick über die globalen Trends der weltweiten Krankheitslast der oralen Haupterkrankungen, die von starken Ungleichheiten geprägt sind. Verbesserungsansätze aus der bevölkerungsweiten Risikoreduktion und Prävention, der Versorgungsplanung sowie gesundheitspolitische Lösungen werden kurz vorgestellt. Dabei werden die im internationalen Diskurs wichtigen Themen angesprochen und die im Rahmen einer Lancet-Artikelserie zur globalen Mundgesundheit aus dem Jahr 2019 entwickelten Reformbereiche besprochen. Schließlich werden neue Initiativen diskutiert sowie Empfehlungen für die deutsche und internationale gesundheitliche Entwicklungspolitik gegeben, die in den kommenden Jahren die Situation der globalen Mundgesundheit entscheidend verbessern könnten.
Comparative studies on the durability and moisture performance of wood modified with cyclic N-methylol and N-methyl compounds
Authors: Emmerich Lukas , Ehrmann Alexander , Brischke Christian , Militz Holger 
Published: June 2021

AbstractGlyoxal-based condensation resins like 1,3-dimethylol-4,5-dihydroxyethyleneurea (DMDHEU) have been used to modify wood and improve its resistance against decaying fungi. High biological durability of DMDHEU-treated wood has already been confirmed in laboratory and field tests in the past. However, the modes of protective action behind an improved decay resistance are not fully understood yet. Furthermore, it is questionable how the use of formaldehyde-poor N-methylol and formaldehyde-free N-methyl compounds instead of DMDHEU affects the moisture behavior and durability, respectively. In this study, wood blocks were treated with N-methylol (DMDHEU, methylated DMDHEU) and N-methyl compounds (1,3-dimethyl-4,5-dihydroxyethyleneurea; DMeDHEU). Untreated and modified specimens were exposed to different moisture regimes and wood-destroying fungi in order to study the indicators that control changes in the wetting ability and decay resistance. Both N-methylol and N-methyl compounds decreased the water uptake and release and increased the durability of Scots pine sapwood from ‘not durable’ (DC 5) to ‘very durable to durable’ (DC 1–2). However, high fluctuations were observed in water uptake and release as well as mass loss (ML) caused by fungal decay, when modified specimens were tested without passing through a cold-water leaching. Consequently, a significant effect of the leaching procedure according to EN 84 on the durability classification could be established. The latter appeared more pronounced for treatments with N-methyl compounds compared to N-methylol compounds. Finally, wetting ability (kwa) and resistance indicating factors (kinh) enabled a forecast of high biological durability for both treatments with N-methylol and N-methyl compounds under real service life conditions.
A New Argument for the Groundedness of Grounding Facts
Authors: Correia Fabrice 
Published: June 2021

AbstractMany philosophers have recently been impressed by an argument to the effect that all grounding facts about “derivative entities”—e.g. the facts expressed by the (let us suppose) true sentences ‘the fact that Beijing is a concrete entity is grounded in the fact that its parts are concrete’ and ‘the fact that there are cities is grounded in the fact that p’, where ‘p’ is a suitable sentence couched in the language of particle physics—must themselves be grounded. This argument relies on a principle,Purity, which states that facts about derivative entities are non-fundamental. Purity is questionable. In this paper, I introduce a new argument—the argument fromSettledness—for a similar conclusion but which does not rely on Purity. The conclusion of the new argument is that every “thick” grounding fact is grounded, where a grounding fact [F is grounded in G, H, …] is said to be thick when at least one of F, G, H, … is a fact—a condition that is automatically satisfied if grounding is factive. After introducing the argument, I compare it with the argument from Purity, and I assess its cogency relative to the relevant accounts of the connections between grounding and fundamentality that are available in the literature.
Combination chemotherapy versus temozolomide for patients with methylated MGMT (m-MGMT) glioblastoma: results of computational biological modeling to predict the magnitude of treatment benefit
Authors: Castro Michael , Pampana Anusha , Alam Aftab , Parashar Rajan , Rajagopalan Swaminathan , Lala Deepak Anil , Roy Kunal Ghosh Ghosh , Basu Sayani , Prakash Annapoorna , Nair Prashant , Joseph Vishwas , Agarwal Ashish , G Poornachandra , Behura Liptimayee , Kulkarni Shruthi , Choudhary Nikita Ray , Kapoor Shweta 
Published: June 2021

Abstract
Background
A randomized trial in glioblastoma patients with methylated-MGMT (m-MGMT) found an improvement in median survival of 16.7 months for combination therapy with temozolomide (TMZ) and lomustine, however the approach remains controversial and relatively under-utilized. Therefore, we sought to determine whether comprehensive genomic analysis can predict which patients would derive large, intermediate, or negligible benefits from the combination compared to single agent chemotherapy.

Methods
Comprehensive genomic information from 274 newly diagnosed patients with methylated-MGMT glioblastoma (GBM) was downloaded from TCGA. Mutation and copy number changes were input into a computational biologic model to create an avatar of disease behavior and the malignant phenotypes representing hallmark behavior of cancers. In silico responses to TMZ, lomustine, and combination treatment were biosimulated. Efficacy scores representing the effect of treatment for each treatment strategy were generated and compared to each other to ascertain the differential benefit in drug response.

Results
Differential benefits for each drug were identified, including strong, modest-intermediate, negligible, and deleterious (harmful) effects for subgroups of patients. Similarly, the benefits of combination therapy ranged from synergy, little or negligible benefit, and deleterious effects compared to single agent approaches.

Conclusions
The benefit of combination chemotherapy is predicted to vary widely in the population. Biosimulation appears to be a useful tool to address the disease heterogeneity, drug response, and the relevance of particular clinical trials observations to individual patients. Biosimulation has potential to spare some patients the experience of over-treatment while identifying patients uniquely situated to benefit from combination treatment. Validation of this new artificial intelligence tool is needed.
Cross-Modality Imaging of Murine Tumor Vasculature—a Feasibility Study
Authors: Zopf Lydia M. , Heimel Patrick , Geyer Stefan H. , Kavirayani Anoop , Reier Susanne , Fröhlich Vanessa , Stiglbauer-Tscholakoff Alexander , Chen Zhe , Nics Lukas , Zinnanti Jelena , Drexler Wolfgang , Mitterhauser Markus , Helbich Thomas , Weninger Wolfgang J. , Slezak Paul , Obenauf Anna , Bühler Katja , Walter Andreas 
Published: June 2021

AbstractTumor vasculature and angiogenesis play a crucial role in tumor progression. Their visualization is therefore of utmost importance to the community. In this proof-of-principle study, we have established a novel cross-modality imaging (CMI) pipeline to characterize exactly the same murine tumors across scales and penetration depths, using orthotopic models of melanoma cancer. This allowed the acquisition of a comprehensive set of vascular parameters for a single tumor. The workflow visualizes capillaries at different length scales, puts them into the context of the overall tumor vessel network and allows quantification and comparison of vessel densities and morphologies by different modalities. The workflow adds information about hypoxia and blood flow rates. The CMI approach includes well-established technologies such as magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and ultrasound (US), and modalities that are recent entrants into preclinical discovery such as optical coherence tomography (OCT) and high-resolution episcopic microscopy (HREM). This novel CMI platform establishes the feasibility of combining these technologies using an extensive image processing pipeline. Despite the challenges pertaining to the integration of microscopic and macroscopic data across spatial resolutions, we also established an open-source pipeline for the semi-automated co-registration of the diverse multiscale datasets, which enables truly correlative vascular imaging. Although focused on tumor vasculature, our CMI platform can be used to tackle a multitude of research questions in cancer biology.
Multiple Functional Brain Networks Related to Pain Perception Revealed by fMRI
Authors: Damascelli Matteo , Woodward Todd S. , Sanford Nicole , Zahid Hafsa B. , Lim Ryan , Scott Alexander , Kramer John K. 
Published: June 2021

AbstractThe rise of functional magnetic resonance imaging (fMRI) has led to a deeper understanding of cortical processing of pain. Central to these advances has been the identification and analysis of “functional networks”, often derived from groups of pre-selected pain regions. In this study our main objective was to identify functional brain networks related to pain perception by examining whole-brain activation, avoiding the need for a priori selection of regions. We applied a data-driven technique—Constrained Principal Component Analysis for fMRI (fMRI-CPCA)—that identifies networks without assuming their anatomical or temporal properties. Open-source fMRI data collected during a thermal pain task (33 healthy participants) were subjected to fMRI-CPCA for network extraction, and networks were associated with pain perception by modelling subjective pain ratings as a function of network activation intensities. Three functional networks emerged: a sensorimotor response network, a salience-mediated attention network, and the default-mode network. Together, these networks constituted a brain state that explained variability in pain perception, both within and between individuals, demonstrating the potential of data-driven, whole-brain functional network techniques for the analysis of pain imaging data.
Biologia Futura: is ADAM 17 the reason for COVID-19 susceptibility in hyperglycemic and diabetic patients?
Authors: Stepanova Ganna 
Published: June 2021

AbstractCOVID-19 is a disease-causing current pandemic. It prevails in patients with pre-existing conditions such as diabetes and hypertension. Renin–angiotensin system was identified as a center of COVID-19 pathophysiology. There is a current controversy concerning the usage of ACE inhibitors and AR blockers in patients with COVID-19. Multiple clinical trials are on the way to determine the effect of RAS blockers in patients with COVID-19. ACE2 receptor is thought to be the point of entry utilized by a coronavirus. However, other factors have been identified which potentially facilitate SARS-CoV-2 entry into the cell. ADAM17 could facilitate viral entry in hyperglycemic and diabetic patients. Insulin is an ADAM17 inhibitor. Heme oxygenase (HO)-1 level is reduced in diabetic patients, contributing to the worst outcome for patients with poor glycemic control. The combined therapy of glycemic control and antioxidant response to oxidative stress could be explored in patients with COVID-19.
Tight bounds on the mutual coherence of sensing matrices for Wigner D-functions on regular grids
Authors: Bangun Arya , Behboodi Arash , Mathar Rudolf 
Published: June 2021

AbstractMany practical sampling patterns for function approximation on the rotation group utilizes regular samples on the parameter axes. In this paper, we analyze the mutual coherence for sensing matrices that correspond to a class of regular patterns to angular momentum analysis in quantum mechanics and provide simple lower bounds for it. The products of Wigner d-functions, which appear in coherence analysis, arise in angular momentum analysis in quantum mechanics. We first represent the product as a linear combination of a single Wigner d-function and angular momentum coefficients, otherwise known as the Wigner 3j symbols. Using combinatorial identities, we show that under certain conditions on the bandwidth and number of samples, the inner product of the columns of the sensing matrix at zero orders, which is equal to the inner product of two Legendre polynomials, dominates the mutual coherence term and fixes a lower bound for it. In other words, for a class of regular sampling patterns, we provide a lower bound for the inner product of the columns of the sensing matrix that can be analytically computed. We verify numerically our theoretical results and show that the lower bound for the mutual coherence is larger than Welch bound. Besides, we provide algorithms that can achieve the lower bound for spherical harmonics.
Concepts and Terms for Addressing Disparities in Public Health Emergencies: Accounting for the COVID-19 Pandemic and the Social Determinants of Health in the United States
Authors: Levine Cheryl A. , Jansson Daire R. 
Published: June 2021

AbstractPublic health emergencies, including the coronavirus disease 2019 (COVID-19) pandemic, highlight disproportionate impacts faced by populations with existing disparities. Concepts and terms used to describe populations disproportionately impacted in emergencies vary over time and across disciplines, but United States (US) federal guidance and law require equal access to our nation’s emergency resources. At all levels of emergency planning, public health and their partners must be accountable to populations with existing inequities, which requires a conceptual shift toward using the data-driven social determinants of health (SDOH). SDOH are conditions in which people are born, live, learn, work, play, worship, and age that affect a wide range of health, functioning, and quality of life outcomes and risks. This article reviews the historic use of concepts and terms to describe populations disproportionately impacted by emergencies. It also recommends a shift in emergency activities toward interventions that target the SDOH to adequately address long-standing systemic health disparities and socioeconomic inequities in the United States.
On topological rank of factors of Cantor minimal systems
Authors: GOLESTANI NASSER , HOSSEINI MARYAM 
Published: June 2021

AbstractA Cantor minimal system is of finite topological rank if it has a Bratteli–Vershik representation whose number of vertices per level is uniformly bounded. We prove that if the topological rank of a minimal dynamical system on a Cantor set is finite, then all its minimal Cantor factors have finite topological rank as well. This gives an affirmative answer to a question posed by Donoso, Durand, Maass, and Petite in full generality. As a consequence, we obtain the dichotomy of Downarowicz and Maass for Cantor factors of finite-rank Cantor minimal systems: they are either odometers or subshifts.
The Construction of “Native” Jews in Late Mandate Palestine: An Ongoing Nahda as a Political Project
Authors: Derri Aviv 
Published: June 2021

AbstractThis article concerns the place of late Ottoman Jews in Palestine on the eve of the 1948 War. It focuses on Israel Ben-Zeʾev (Wolfensohn), a Jerusalem-born educator and Nahda intellectual who led a movement of self-identified “native” Jews, including both “Old Yishuv” Ashkenazim and Sephardim, to combat their marginalization by the Zionist institutions. I examine his lifetime struggle to advance the study of Arabic and “Arab Jews” (yahud ʿarab) under early Islam by creating institutions of knowledge production and educational programs modeled on those he knew from his early academic career in Cairo. It was in the context of these struggles that demands for separate political representation for native Jews and for a specialized field of Arab Jewish studies coalesced as part of a broader project of a shared Arab-Jewish cultural modernization. They culminated in 1948, when Ben-Zeʾev finally realized his Arabic library project, ironically using looted Palestinian books, only to see its destruction four years later by Zionist leaders and Hebrew University professors.