bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early skin contact combined with mother’s breastfeeding to shorten the process of premature infants ≤ 30 weeks of gestation to achieve full oral feeding: the study protocol of a randomized controlled trial
Authors: Li Liling , Wang Li , Niu Conway , Liu Chan , Lv Tianchan , Ji Futing , Yu Ling , Yan Weili , Dou Ya Lan , Wang Yin , Cao Yun , Huang Guoying , Hu Xiaojing 
Published: September 2021

Abstract
Background
Most hospitalized preterm infants experience difficulties in transitioning from tube feeding to full oral feeding. Interventions to promote full oral feeding in preterm infants in the neonatal intensive care unit (NICU) are limited to pacifier use or bottle-feeding exercises. Skin contact has been shown to be beneficial to start and maintain lactation and provide preterm infants with the opportunity to suck on the mother’s breast, which may promote further development of the preterm infant’s suckling patterns. The objective of this study is to compare and evaluate the effects of skin contact combined with breastfeeding (suck on the mother’s empty breast) as compared to the routine pacifier suckling training model in achieving full oral feeding for infants whose gestational age are ≤ 30 weeks.

Methods
This is a single-center, randomized controlled clinical trial conducted in the NICU and designed according to the SPIRIT Statement. The subjects included in the study are premature infants born between April 2020 and July 2021 with a gestational age of ≤30 weeks, birth weight of <1500 g, admission age of <72 h, and absence of congenital malformations. Those with oxygenation indices of >40 and those born to mothers with poor verbal communication skills will be excluded. A sample of 148 infants is needed. The infants will be randomized to the intervention (skin contact combined with mother’s breastfeeding model) or control group (routine pacifier sucking training model). The primary outcome is the time required to achieve full oral feeding. The secondary outcomes are the breastfeeding abilities of preterm infants as assessed by the Preterm Infant Breastfeeding Behavior Scale (PIBBS), breastfeeding rates at 3 and 6 months corrected gestational age, complication rates, duration of oxygen requirement, days of hospital stay, and satisfaction of parents.

Discussion
This paper describes the first single-center, open-label, randomized clinical trial on this topic and will provide crucial information to support the implementation of skin contact combined with the breastfeeding model in the NICU setting.

Trial registration
ClinicalTrials.gov NCT 04283682. Registered on 8 February 2020.
Techno-economic analysis for the role of single end energy user in mitigating GHG emission
Authors: Ahmed Waqas , Sheikh Jamil Ahmed , Nouman Muhammad , Ullah Mian Farhan , Mahmud M. A. Parvez 
Published: September 2021

Abstract
Background
Households, as end energy users, consume grid electricity to meet their energy demands. However, grids across the globe for energy production are majorly based on fossil fuel technology and make the highest contributions to global warming and climate change due to greenhouse gases (GHG) emissions. This generic study aims to investigate the minute role of a single-end energy consumer in GHG mitigation by switching to a rooftop PV system to meet his energy demands and trading surplus energy to the grid through its techno-economic analysis.

Method
For the study impact, NASA Meteorological Data are used to select an ideal single energy user equipped with a 10-kW PV system based on annual average daily solar radiation and ambient temperature through MATLAB/Simulink, for 11 populous cities in Pakistan. Helioscope software is used to select tilt and azimuthal angles to maximize the solar radiation intercept. Afterward, RETScreen software is used for cost, financial and GHG analysis.

Result and conclusion
A single end energy user equipped with a 10-kW PV system switched to a green energy source from a fossil fuel-based grid has the potential to avoid the burning of 3570.6 L of gasoline by producing 16,832 kWh of green energy per annum, while financially recovering the 10-kW PV system’s 7337$ grid-tied investment in 5 years (equity) and in 9 years (equity) in a 9077$ stand-alone system over its 25-year life. This approach provides relief to end energy users from high priced grid electricity through environmental friendliness by mitigating 8.3 tons of CO2 equivalent emissions per annum from energy production, while providing relief to the main grid by grid stabilization through peak shaving, in the broad sense.
Sexual quality of life and sexual self-efficacy among women during reproductive-menopausal transition stages and postmenopause: a comparative study
Authors: Riazi Hedyeh , Madankan Fatemeh , Azin Seyed Ali , Nasiri Maliheh , Montazeri Ali 
Published: September 2021

AbstractSexual self-efficacy is essential for appropriate and desirable sexual function and sexual quality of life. This study aimed to compare sexual quality of life and sexual self-efficacy among women during reproductive-menopausal transition stages and postmenopause. This was a cross-sectional study of a sample of Iranian women. The sexual quality of life-female (SQOL-F) scale was used to measure sexual quality of life (SQOL) and sexual self-efficacy (SSE) was measured using the sexual self-efficacy questionnaire (SSEQ). Data were compared between the study groups using multiple linear regression. In all 340 women (170 in reproductive-menopausal transition stages and 170 postmenopause) were studied. The mean ages of reproductive-menopausal transition stages and postmenopausal women was 30.8 ± 6.55 and 56.3 ± 3.54 respectively (P < 0.001). Sexual self-efficacy and sexual quality of life were found to be significantly higher in reproductive-menopausal transition stages compared with postmenopause women (P < 0.001 and P = 0.017 respectively). Sexual and relationship satisfaction and sexual repression subscales differed significantly between the two groups (P = 0.001 and P < 0.001 respectively). Higher sexual self-efficacy contributed to higher sexual quality of life (P < 0.0001). Reproductive-menopausal transition stages women appear to enjoy higher levels of sexual self-efficacy and sexual quality of life. Given the importance of sexual quality of life, it is recommended to pay greater attention to sexual self-efficacy among postmenopausal women in order to improve sexual quality of life in this population.
Testing an online measure of portion size selection: a pilot study concerned with the measurement of ideal portion size
Authors: Embling Rochelle , Lee Michelle D. , Price Menna , Wilkinson Laura L. 
Published: September 2021

Abstract
Background
Portion size is known to be a key driver of food intake. As consumed portions are often pre-planned, ‘ideal portion size’—an individual’s preferred meal size selected prior to eating—has been identified as a strong predictor of actual consumption. However, assessments of ideal portion size have predominantly relied on laboratory-based computer tasks, limiting use online. Therefore, this cross-sectional study sought to pilot test the validity of a web-based tool to measure ideal portion size.

Methods
In an online study (N = 48), participants responded to images of a range of foods. Each food was photographed in a series of different portions and loaded into an ‘image carousel’ that would allow participants to change the size of the displayed portion by moving a slider left-to-right. Using this image carousel, participants selected their ideal portion size. They also completed measures of expected satiety and expected satiation and self-reported their age and body mass index (BMI). A non-parametric correlation matrix was used to explore associations between ideal portion size and identified predictors of food intake.

Results
Supporting convergent validity of this measure, ideal portion size was significantly correlated with expected satiety (rs = .480) and expected satiation (rs = −.310) after controlling for effects of baseline hunger and fullness, consistent with past research. Similarly, supporting divergent validity of this measure, ideal portion size was not significantly correlated with age (rs = −.032) or BMI (rs = −.111,).

Conclusions
Pilot results support the validity of this web-based portion size selection tool used to measure ideal portion size, though further research is needed to validate use with comparisons to actual food intake.
Epidemiological profile of brain tumors in Cameroon: a retrospective study
Authors: Motah Mathieu , Gams Massi Daniel , Fouda Bekolo Fabien , Akweseh Nju Nkemontoh , Ndoumbe Aurélien , Moumi Mireille , Sango Anne , Shu Paul , Eyenga Victor 
Published: September 2021

Abstract
Background
Brain tumors represent group of neoplasms originating from intracranial tissues and the meninges. The aim of this study was to determine the epidemiological profile of brain tumors seen in a referral health center in Cameroon. We carried out a 10-year retrospective study in the neurosurgical, neurology, pathology, oncology and radiotherapy units of our hospital.

Results
We found 150 complete case files accounting for 0.7% of total admissions in the various units. Males accounted for 50.7% of the cases. Children less than 14 years represented 12.7% of cases (n = 19). Primary brain tumors constituted 92% (n = 138). Most patients with primary brain tumors were between 25 and 54 years of age, making up 57% of cases (n = 79). The most prevalent histological type of brain tumor was meningioma (26%, n = 39), followed by astrocytoma (24.7%, n = 37), and pituitary adenomas (18%, n = 27). The majority of cases presented with signs of raised intracranial pressure with headache being the most frequent symptom (88%). Some patients presented with seizures (34%), neurological deficit (13%), visual disturbances (10%), and cognitive disorders (7%).

Conclusion
Young adults represent the most affected age group. Meningioma, astrocytoma and pituitary adenomas were the most frequent brain tumors in adults. Further studies are needed to assess the long-term outcome of patients with BTs.
Multidrug resistant E. coli recovered from household reared female budgerigar pet bird (Melopsittacus undulatus) in Ibadan, Oyo State Nigeria: a case report
Authors: Okunlade Adelekan Oluseyi , Esan Oluwaseun Olanrewaju , Ogunleye Akinlabi Oladele 
Published: September 2021

Abstract
Background
Pet birds are housed and reared exclusively for ornamental use. These include psittaciformes (parrots, parakeets, budgerigars, love birds) and passeriformes (e.g. canaries, finches, sparrows, also called songbirds). E. coli is a Gram negative bacterium. In birds, it is called Avian Pathogenic E. coli and is a causative agent of avian colibacillosis. Antimicrobial resistance is the process through which bacteria evade the activity of antibiotics. According to WHO (World Health Organization), antibiotic resistance is the result of indiscriminate use of these drugs which are used both in Veterinary and human medicine.

Case presentation
A one and half year old yellow female budgerigar pet bird (Melopsittacus undulatus) with patches of black and white on wings and back, kept as companion (one out of four) was presented dead at the avian clinic section of the Veterinary Teaching Hospital, University of Ibadan, Nigeria. It was reported to have presented signs of anorexia and diarrhea for two days before death. Provisional diagnosis was colibacillosis. Intestinal samples were sent for microbial culture and sensitivity. The samples yielded growth of E. coli. Antimicrobial susceptibility revealed that the organism showed resistance to all tested antibiotics.

Conclusions
Multidrug-resistant Escherichia coli constitutes a major public health concern. The constant interaction between household companion birds and humans gives room for disease transmission. Wild birds kept as pets or companions harbor pathogenic and zoonotic pathogens, hence a threat to public health.
Acute lymphoblastic leukemia simulating breast carcinoma
Authors: Masood Laiba , Sayeed Sana , Aslam Samreen 
Published: September 2021

Abstract
Background
Breast metastasis in hematological malignancies is a rare phenomenon, and it is primarily seen in acute myeloid leukemia (AML). In patients with acute lymphoblastic leukemia (ALL), this condition is even rarer.
Case presentation.
We present a case of a precursor B cell ALL involving breast in a 40-year-old female and its imaging features on mammography and ultrasound. Histopathology of core needle biopsy (CNB) specimen allowed us to diagnose ALL with extramedullary metastases. The patient was referred to oncology for further management.

Conclusion
To conclude, ALL infiltrating breast is rare but should be given due consideration, especially in the cases of known primary hematopoietic malignancy, particularly in patients presenting with a history of sudden lumps in the breast. A CNB can give reliable results in combination with flow cytometry and immunocytochemistry, circumventing the need for an excisional biopsy and allowing the commencement of early treatment.
Arabic translation and validation of the Nasal Obstruction Symptom Evaluation (NOSE) scale
Authors: Elwany Samy , Atef Ahmed , Ismail Ahmed Soliman , Hussein Wael K. A. , Ibrahim Ahmed Aly , Abdelnaby Mostafa , Elgersh Mohamed , Elwany Mohamed 
Published: September 2021

Abstract
Background
The Nasal Obstruction Symptom Evaluation (NOSE) scale has been developed and validated in English to overcome the controversies concerning other methods of evaluation of nasal obstruction. The scale is currently used worldwide and has been translated into several languages. The purpose of the present work was to translate the English (NOSE) scale into Arabic (A-NOSE) and to assess its validity and reliability in Arabic-speaking patients.

Results
The internal consistency and test-to-test reliability of the Arabic scale were statistically good. The differences between the scores of the patients and control subjects were statistically significant. Postoperative scores of the patients were significantly higher than preoperative scores. All participants completed the Arabic questionnaire easily and few of them required slight assistance.

Conclusions
The translated NOSE scale is easy to administer and can be a robust and usable outcome measure for patients with nasal obstruction. The translated scale is sensitive to changes in nasal airway patency and can be used in clinical practice and outcome research.
Targeted Mutational Analysis of Cortisol-Producing Adenomas
Authors: Rege Juilee , Hoxie Jessie , Liu Chia-Jen , Cash Morgan N , Luther James M , Gellert Lan , Turcu Adina F , Else Tobias , Giordano Thomas J , Udager Aaron M , Rainey William E , Nanba Kazutaka 
Published: September 2021

AbstractContextSomatic gene mutations have been identified in only about half of cortisol-producing adenomas (CPAs). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1.ObjectiveThis work aims to expand our understanding of the prevalence of somatic mutations in CPAs from patients with overt Cushing syndrome (OCS) and “subclinical” mild autonomous cortisol excess (MACE), with an immunohistochemistry (IHC)‒guided targeted amplicon sequencing approach using formalin-fixed paraffin-embedded (FFPE) tissue.MethodsWe analyzed FFPE adrenal tissue from 77 patients (n = 12 men, 65 women) with either OCS (n = 32) or MACE (n = 45). Using IHC for 17α-hydroxylase/17,20-lyase (CYP17A1) and 3β-hydroxysteroid dehydrogenase (HSD3B2), we identified 78 CPAs (32 OCS CPAs and 46 MACE CPAs). Genomic DNA was isolated from the FFPE CPAs and subjected to targeted amplicon sequencing for identification of somatic mutations.ResultsSomatic mutations were identified in 71.8% (56/78) of the CPAs. While PRKACA was the most frequently mutated gene in OCS CPAs (14/32, 43.8%), somatic genetic aberrations in CTNNB1 occurred in 56.5% (26/46) of the MACE CPAs. Most GNAS mutations were observed in MACE CPAs (5/7, 71.4%). No mutations were observed in PRKAR1A. In addition to the known mutations, we identified one previously unreported mutation in PRKACA. Two patients with MACE harbored 2 adjacent tumors within the same adrenal gland - one patient had 2 CPAs, and the other patient had a CPA and an aldosterone-producing adenoma (identified by IHC for aldosterone synthase).ConclusionA comprehensive FFPE IHC-guided gene-targeted sequencing approach identified somatic mutations in 71.8% of the CPAs. OCS CPAs demonstrated a distinct mutation profile compared to MACE CPAs.
Low-Iodine Diet of 4 Days Is Sufficient Preparation for 131I Therapy in Differentiated Thyroid Cancer Patients
Authors: Dekker Bernadette L , Links Mirthe H , Muller Kobold Anneke C , Swart-Busscher Linda G , Kars Marleen , Bons Judith A P , Brouwers Adrienne H , Links Thera P , van der Horst-Schrivers Anouk N A 
Published: September 2021

AbstractContextNo consensus exists about the optimal duration of the low-iodine diet (LID) in the preparation of 131I therapy in differentiated thyroid cancer (DTC) patients.ObjectiveThis work aimed to investigate if a LID of 4 days is enough to achieve adequate iodine depletion in preparation for 131I therapy. In addition, the nutritional status of the LID was evaluated.MethodsIn this prospective study, 65 DTC patients treated at 2 university medical centers were included between 2018 and 2021. The patients collected 24-hour urine on days 4 and 7 of the LID and kept a food diary before and during the LID. The primary outcome was the difference between the 24-hour urinary iodine excretion (UIE) on both days.ResultsThe median 24-hour UIE on days 4 and 7 of the LID were not significantly different (36.1 mcg [interquartile range, 25.4-51.2 mcg] and 36.5 mcg [interquartile range, 23.9-47.7 mcg], respectively, P = .43). On day 4 of the LID, 72.1% of the DTC patients were adequately prepared (24-hour UIE &lt; 50 mcg), and 82.0% of the DTC patients on day 7 (P = .18). Compared to the self-reported regular diet, DTC patients showed a significantly (P &lt; .01) lower percentage of nutrient intake (calories, protein, calcium, iodine, and water) during the LID.ConclusionThe 24-hour UIE on day 4 of the LID did not differ from day 7, and therefore shortening the LID from 7 to 4 days seems justified to prepare DTC patients for 131I therapy in areas with sufficient iodine intake and may be beneficial to maintain a sufficient nutritional intake during DTC treatment.
Metabolic Homeostasis: It’s All in the Timing
Authors: Brubaker Patricia L , Martchenko Alexandre 
Published: September 2021

AbstractCross-talk between peripheral tissues is essential to ensure the coordination of nutrient intake with disposition during the feeding period, thereby preventing metabolic disease. This mini-review considers the interactions between the key peripheral tissues that constitute the metabolic clock, each of which is considered in a separate mini-review in this collation of articles published in Endocrinology in 2020 and 2021, by Martchenko et al (Circadian rhythms and the gastrointestinal tract: relationship to metabolism and gut hormones); Alvarez et al (The microbiome as a circadian coordinator of metabolism); Seshadri and Doucette (Circadian regulation of the pancreatic beta cell); McCommis et al (The importance of keeping time in the liver); Oosterman et al (The circadian clock, shift work, and tissue-specific insulin resistance); and Heyde et al (Contributions of white and brown adipose tissues to the circadian regulation of energy metabolism). The use of positive- and negative-feedback signals, both hormonal and metabolic, between these tissues ensures that peripheral metabolic pathways are synchronized with the timing of food intake, thus optimizing nutrient disposition and preventing metabolic disease. Collectively, these articles highlight the critical role played by the circadian clock in maintaining metabolic homeostasis.
Association between maternal antenatal care visits and newborn low birth weight in Bangladesh: a national representative survey
Authors: Ahmed Md. Sabbir , Sahrin Sumaia , Yunus Fakir Md 
Published: September 2021

Background: Low Birth Weight (LBW) is a global health concern for childhood mortality and morbidity. The objectives of this study were to assess the association between the number of Antenatal Care Visits (ANC) and LBW among Bangladeshi newborns, and to identify the demographic and socio-economic predictors of LBW. Methods: Our present cross-sectional study is based on the secondary data of the Bangladesh Demography and Health Survey (BDHS) 2014. Complete data of 4,235 (weighted) mother-child pairs were included in the analysis. Results: The overall prevalence of LBW among newborns were found to be 19.3% (95% CI: 17.8-20.9). Among the mothers who received antenatal care services 1-3 times during pregnancy, 35% had less possibility of having LBW babies [COR = 0.65, 95% CI: 0.50-0.85]. The association remained significant after adjusting the analysis with the sex of the newborn, administrative regions (division), maternal educational status, mother’s weight status and fathers’ occupation [AOR = 0.74, 95% CI: 0.55-0.99]. Additionally, the sex of the newborn, division, maternal education, maternal weight status, and fathers’ occupational status were found to be significantly associated with LBW. Conclusion: Increasing the coverage of antenatal services and enabling mothers to receive quality antenatal services may substantially contribute to reducing the prevalence of LBW in Bangladesh.
Barriers and facilitators to the implementation of osteoarthritis management programmes in primary or community care settings: a systematic review and qualitative framework synthesis protocol
Authors: Cunningham Joice , M. Briggs Andrew , Cottrell Elizabeth , Doyle Frank , Dziedzic Krysia , Finney Andrew , Murphy Paul , Paskins Zoe , Sheridan Eoin , Swaithes Laura , P. French Helen 
Published: September 2021

Despite consistent international guidelines for osteoarthritis (OA) management, evidence-based treatments are underutilised. OA management programmes (OAMPs) are being implemented internationally to address this evidence-practice gap. An OAMP is defined as a ‘model of evidence-based, non-surgical OA care that has been implemented in a real-world setting’. Our objective is to identify, synthesise and appraise qualitative research identifying anticipated or experienced micro (individual/behavioural), meso (organisational) or macro (context/system) level barriers or facilitators to the implementation of primary or community care-based OAMPs. Five electronic databases will be searched for papers published between 2010 and 2021. Qualitative or mixed-methods studies that include qualitative data on the anticipated or experienced barriers or facilitators to the implementation of primary or community care-based OAMPs, from the perspective of service users or service providers, will be included. The review will be reported using the PRISMA and ENTREQ guidelines. A data extraction form will be used to provide details of the included studies. Data will be analysed and identified barriers and facilitators will be mapped onto an appropriate implementation framework, such as the Theoretical Domains Framework. The appropriate JBI critical appraisal tools will be used to assess methodological quality, while the GRADE‐CERQual approach will be used to assess confidence in the findings. Translation of evidence-based guidelines into practice is challenging and reliant on the quality of implementation. By comparing and contrasting anticipated and experienced barriers, this review will determine the extent of congruence between the two, and provide valuable insights into the views and experiences of key stakeholders involved in the implementation of OAMPs. The mapping of identified barriers and facilitators to behaviour change theory will enhance the applicability and construct validity of our findings and will offer significant utility for future development and implementation of OAMPs. Registration: This protocol was registered with PROSPERO (CRD42021255698) on 15/07/21.