bluuebunny/crossref_metadata_2025_split huggingface dataset:
10080 Quantifying type of dental treatment rendered for patients with special needs
Authors: Chavis Sydnee 
Published: March 2021

ABSTRACT IMPACT: Quantifying the types of dental procedures patients with healthcare needs receive can help understand and improve modalities of dental care to improve healthcare outcomes. OBJECTIVES/GOALS: 1. Quantify how medical complexity based on special needs diagnosis impacts dental treatment rendered2. Comprehend how medical diagnosis of a special need can affect rate of treatment and type of treatment METHODS/STUDY POPULATION: This study consists of a chart review of all active patients in a dental school setting who have one of the following diagnoses of a special need: autism, developmental disorder, epilepsy, cerebral palsy, neuromuscular disorder, and hydrocephaly. Medical diagnoses were used to extract records and quantify the types of dental treatment rendered for these patients (preventative, restorative, and surgical), as well as the rates of appointments for this patient population. RESULTS/ANTICIPATED RESULTS: The medical complexity of patients of this population, as defined by the number medical diagnoses, impacts the type of treatment rendered as well as how frequently these patients are seen for dental care (rate of appointments). DISCUSSION/SIGNIFICANCE OF FINDINGS: Over- or under-utilization of dental treatment modalities can impact the oral health status and outcomes for patients with special needs. The differences in types and frequency/ rate of dental treatment rendered for patients of different medical complexity can further impede their oral health and systemic health status and health outcomes.
73662 Racial Disparities in Septic Shock Mortality: Results from the OneFlorida Data Trust Cohort
Authors: Black Lauren Page , Hopson Charlotte , DeVos Elizabeth , Puskarich Michael , Fernandez Rosemarie , Guirgis Faheem , Garvan Cynthia 
Published: March 2021

ABSTRACT IMPACT: Identifying racial disparities in septic shock mortality, a common and lethal condition, can inform future research and policy efforts aimed at understanding the drivers these disparities and addressing the underlying factors in order to reduce disparities and improve health. OBJECTIVES/GOALS: Septic shock is a major public health problem with significant mortality. Existing data indicate racial disparities in sepsis incidence, but evidence is limited on differences in septic shock outcomes. Our objective was to determine the association between race and septic shock mortality in a statewide cohort while controlling for clinical factors. METHODS/STUDY POPULATION: This was a retrospective analysis of septic shock patients in the One Florida Data Trust between 2012-18. Data was collected regarding age, sex, race, insurance status, and selected comorbid conditions [liver disease, hypertension, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), end-stage renal disease (ESRD), and human immunodeficiency virus infection (HIV)]. To account for severity of illness, we assigned Sequential Organ Failure Assessment scores for components based on laboratory values (labSOFA), and collected data on mechanical ventilation use and initial lactate.The primary outcome was 90-day mortality. The Least Absolute Shrinkage and Selection Operator (LASSO) method was used for variable selection for the multivariable regression model. RESULTS/ANTICIPATED RESULTS: There were 13,932 septic shock patients with a mean (SD) age of 61(16) years. Of these, 68% identified as white, 28% as black, 2.1% as Hispanic, and 2.0% as other races. 90-day mortality was 32% (n=4,437) and 59% required mechanical ventilation. Significant independent predictors of mortality in the regression model were age (OR 1.04; p<0.01), black race (1.72; p<0.01), lactate (1.10; p<0.01), mechanical ventilation (3.62; p<0.01), labSOFA (1.18; p<0.01), history of liver disease (1.75; p<0.01), hypertension (0.70; p<0.01), COPD (0.87; p<0.01), CHF (1.18; p<0.01), HIV (1.30; p=0.05), and the interaction between age and black race. Black patients had 1.72 times the odds of mortality compared to white patients. For every one-year decrease in age, black patients had a 1% increased odds of mortality (OR 1.01; p < 0.01). DISCUSSION/SIGNIFICANCE OF FINDINGS: Black patients have increased odds of dying from septic shock compared to white patients after controlling for age, selected comorbid conditions, and markers of illness severity. Future work is needed to move beyond demonstrating septic shock disparities and towards understanding the underlying factors.
76215 Implementation of Proteomics as a Diagnostic tool for Nontuberculous mycobacteria (NTM) Infection
Authors: Lapinel Nicole , Guidry Jessie , Varkey Mary , Rijal Manish , Zea Arnold , Ali Juzar 
Published: March 2021

ABSTRACT IMPACT: Implementation of proteomics as a diagnostic tool for Nontuberculous mycobacteria (NTM) infection can provide a more accurate, efficient and cost-effective means for effectively diagnosing disease and enacting timely management decisions which can revolutionize patient care. OBJECTIVES/GOALS: Proteomic analysis is a proven diagnostic modality enabling rapid identification of microorganisms. We sought to apply proteomics to detect proteins unique to the most clinically relevant NTM. We then determined whether these unique proteomes could be used to successfully identify NTM species from in vitro cocktail preparations. METHODS/STUDY POPULATION: NTM reference strains for M. avium, m. intracellulare, m.chimaera, m. abscessus abscessus, m. abscessus massiliense and m. abscessus boletti were cultured in vitro and subjected to proteomic analysis using Liquid Chromatography tandem-Mass Spectrometry (LCMS). Tandem Mass Tag (TMT) data acquisition utilized an MS3 approach for data collection using Proteome Discoverer 2.4.A comparative analysis of the proteome of each of these six species was performed quantitatively using LCMS. The process was repeated for three technical replicates and analyzed using the SEQUEST algorithm. Only high scoring peptides were considered utilizing a false discovery rate (FDR) of 1%. Once species-specific proteins were identified, we validated detection in individual and mixed samples of the six reference strains. RESULTS/ANTICIPATED RESULTS: The proteomic profiling of the six NTM reference strains successfully demonstrated proteins unique to each of the MAC species and MABC subspecies. Proteomic MAC species analysis produced between 327 to 2,540 unique peptides for each of the 3 species. MABC proteomic analysis identified between 17-74 unique peptides for each of the 3 subspecies. Fifteen different mixed preparations of MAC and MABC were then subjected to LCMS analysis and compared against the proteome profiles already curated for the six strains. We accurately identified at least one NTM in the majority of the samples (10/15). In three samples (3/15), the NTM was not correctly identified; in two of the samples (2/15) we were unable to determine the identity of NTM within the preparation. Further database curation will be performed to hone these results. DISCUSSION/SIGNIFICANCE OF FINDINGS: Proteomic analysis of in vitro reference strains successfully demonstrated protein fingerprints specific to six common disease-causing strains of NTM. Such findings can be used to evaluate clinical samples enabling more efficient diagnostic specificity. Further research will focus on identification of NTM in sputum samples of infected patients.
When peace nations go to war: Examining the narrative transformation of Sweden and Norway in Afghanistan
Authors: Sjöstedt Roxanna , Noreen Erik 
Published: March 2021

AbstractWhat happens to dominant narratives and settled self-images of so-called peace nations when experiencing actual combat in out-of-area military missions? This question arises when studying the contemporary international engagement of small states that previously have mostly been engaged in peacekeeping with limited mandates and non-use of force restrictions. As today's international missions have altered radically, it is important to analyse narrative friction and transformation in small states with little prior experience of international war-fighting. This article addresses this lacuna by examining two small states and self-proclaimed peace nations – Sweden and Norway – in relation to their engagement in the International Security Assistance Force (ISAF), the NATO-led security mission to Afghanistan 2002–14. By examining the interplay and discursive struggle of two narratives — peace nation and military culture – this article finds that these narratives constantly constitute and reconstitute a small state's self-image and the boundaries for acceptable or even required behaviour. With altered principles regarding use of force there is an increased friction between the narratives. By addressing these frictions, the article contributes to the literature on small state international military engagement and develops and refines assumptions regarding the drivers and consequences of small state participation in out-of-area missions.
The effect of ultrafiltration transmembrane permeation on the flow field in a surrogate system of an artificial kidney
Authors: De Pascale Matilde , Faria Monica , Boi Cristiana , Semiao Viriato , de Pinho Maria Norberta 
Published: March 2021

Abstract
Renal Replacement Therapies generally associated to the Artificial Kidney (AK) are membrane-based treatments that assure the separation functions of the failing kidney in extracorporeal blood circulation. Their progress from conventional hemodialysis towards high-flux hemodialysis (HFHD) through the introduction of ultrafiltration membranes characterized by high convective permeation fluxes intensified the need of elucidating the effect of the membrane fluid removal rates on the increase of the potentially blood-traumatizing shear stresses developed adjacently to the membrane. The AK surrogate consisting of two-compartments separated by an ultrafiltration membrane is set to have water circulation in the upper chamber mimicking the blood flow rates and the membrane fluid removal rates typical of HFHD. Pressure drop mirrors the shear stresses quantification and the modification of the velocities profiles. The increase on pressure drop when comparing flows in slits with a permeable membrane and an impermeable wall is ca. 512% and 576% for

$ \mathrm{CA}22/5\%{\mathrm{SiO}}_2 $

and

$ \mathrm{CA}30/5\%{\mathrm{SiO}}_2 $

membranes, respectively.
New sphenodontian (Reptilia: Lepidosauria) from a novel Late Triassic paleobiota in western North America sheds light on the earliest radiation of herbivorous lepidosaurs
Authors: Kligman Ben T. , McClure Warren C. , Korbitz Mark , Schumacher Bruce A. 
Published: March 2021

AbstractHerbivory is a common ecological function among extant lepidosaurs, but little is known about the origin of this feeding strategy within Lepidosauria. Here we describe a sphenodontian (Lepidosauria) from the Late Triassic of western North America,Trullidens purgatoriin. gen. n. sp., that reveals new aspects of the earliest radiation of herbivorous lepidosaurs. This taxon is represented by an isolated lower jaw with robust structure bearing transversely widened dentition and extensive wear facets, suggesting a masticatory apparatus specialized for herbivory. An unusual ‘incisor-like’ tooth is present at the anterior end of the jaw; a unique feature among lepidosaurs, this tooth is convergent with the incisors of extant rodents and lagomorphs. Phylogenetic analyses support the placement of this taxon within opisthodontian sphenodontians, a group sharing derived cranio-dental morphologies specialized for herbivory. The new taxon was recovered in a recently discovered and unnamed series of Upper Triassic strata in southeastern Colorado, USA, exposed in Canyons incised by the Purgatoire River and its tributaries. These strata comprise a dominantly red-bed sequence of conglomerates, sandstones, and siltstones deposited in a fluvio-lacustrine setting, preserving a Late Triassic biota of invertebrate and vertebrate ichnofossils, plant macrofossils, bony fish, temnospondyl amphibians, and reptiles. We use aetosaur osteoderms as biostratigraphic links to the nearby Chinle Formation of Arizona, USA, establishing a middle Norian age for these strata. The presence of an opisthodontian from western equatorial Pangaea in the Norian Stage reveals a near-global radiation of this clade across the Pangaean supercontinent during the Late Triassic.UUID:http://zoobank.org/A737c03f-863a-488e-a860-5cc914548774.
PREHISTORIC CHARCOAL GRAFFITI DISCOVERED IN KATEŘINSKÁ CAVE, CZECH REPUBLIC
Authors: Golec Martin , Zajicek Petr , Svetlik Ivo , Pachnerova Brabcova Katerina , Marikova Lucie , Cermakova Eva , Ovsonkova Zuzana Aurelia 
Published: March 2021

ABSTRACTThe article reports on a new sampling method and the archaeological context of cave drawings, which include the oldest currently known graffiti in the Czech Republic. Between 2016 and 2020, samples with a small amount of charcoal were taken from drawings found in Kateřinská Cave (Catherine’s Cave) of the Moravian Karst in the Czech Republic. A new gentle method of sampling charcoal from the cave walls was developed for the purpose of radiocarbon (14C) dating cave drawings of unknown age, while preserving the contours of the drawings. 14C analysis has provided data from four periods of prehistory and history: from the Neolithic around 5000 BC, the turn of the Neolithic and Eneolithic around 4300 BC, the Hallstatt Period from 800–450 BC, and also from the Middle Ages (13th century). The radiocarbon dates of the graffiti correspond to the dates of the pottery finds from the entrance portal of Kateřinská Cave, thus validating the dates and the sampling method.
Variation in PLIN2 and its association with milk traits and milk fat composition in dairy cows
Authors: Li Y. H. , Zhou H. , Cheng L. , Zhao J. , Hickford J. G. H. 
Published: March 2021

AbstractThe current study investigated associations between variation in the bovine perilipin-2 gene (PLIN2) and milk traits (milk fat content, milk protein content, milk yield and milk fatty acid (FA) component levels) in 409 New Zealand pasture-grazed Holstein-Friesian × Jersey-cross (HF × J-cross or Kiwicross™) cows. Five nucleotide sequence variants were found in three regions of the gene, including c.17C>T in exon 2, c.53A>G in exon 3, c.595+23G>A and c.595+104_595+108del in intron 5, and c.*302T>C in the 3′-untranslated region. The c.*302T>C substitution produces two nucleotide sequence variants (A5 and B5), and this variation was associated with variation in milk protein content and milkfat composition for C10:0, C11:0, C12:0, C13:0 and C16:0 FA and medium-chain fatty acid (MCFA) and long-chain fatty acid (LCFA) groups. After correcting for the effect of variation in the diacylglycerol acyl-CoA acyltransferase 1 gene (DGAT1) that results in the amino acid substitution p.K232A, variation in the FA binding protein 4 gene (FABP4) and variation in the stearoyl-CoA desaturase (Δ-9-desaturase) gene (SCD) that results in the amino acids substitution p.A293V, significant differences between A5A5 and B5B5 cows were found for C10:0, C11:0, C12:0, C13:0, C16:0, and the MCFA, LCFA, total saturated FA and C10:1 index groups. This suggests that nucleotide sequence variation in PLIN2 may be affecting milk FA component levels.
Can changes in education alter future population ageing in Asia and Europe?
Authors: Balachandran Arun , James K. S. , van Wissen Leo , Samir K. C. , Janssen Fanny 
Published: March 2021

AbstractWhile population ageing is rising, the educational composition of the elderly remains rather heterogeneous. This study assesses the educational differences in future population ageing in Asia and Europe, and how future population ageing in Asia and Europe would change if the educational composition of its populations changed. A comparative population ageing measure (the Comparative Prospective Old-Age Threshold [CPOAT]) was used, which recalculates old-age thresholds after accounting for differences in life expectancy, and the likelihood of adults surviving to higher ages. Combined data from projected age- and sex-specific life-tables (from the United Nations) and projected age- and sex-specific survival ratios by different levels of education (from the Wittgenstein Centre for Demography and Global Human Capital) were used to construct projected life-tables (2015–2020, …, 2045–2050) by educational level and sex for different regions of Asia and Europe. Based on these life-tables, future comparative prospective old-age thresholds by educational level and sex were calculated. It was found that in both Asia and Europe, and among both men and women, the projected old-age thresholds are higher for higher educated people than for less-educated people. While Europe has a larger projected share of elderly in the population than Asia, Europe’s older population is better educated. In alternative future scenarios in which populations hypothetically have higher levels of education, the projected shares of elderly in the population decrease across all regions of Asia and Europe, but more so in Asia. The results highlight the effectiveness of investing in education as a policy response to the challenges associated with population ageing in Asia and Europe. Such investments are more effective in the Asian regions, where the educational infrastructure is less developed.
Linking people and activities through community mobility: an international comparison of the mobility patterns of older drivers and non-drivers
Authors: Unsworth Carolyn , Dickerson Anne , Gélinas Isabelle , Harries Priscilla , Margot-Cattin Isabel , Mazer Barbara , Stapleton Tadhg , Swanepoel Lizette , Timmer Amanda , Niekerk Lana Van , Vrkljan Brenda 
Published: March 2021

AbstractCommunity mobility using private and public transportation is important for maintaining health, social participation and living well in later life. This international cross-sectional cohort study (N = 246) reported on the health and driving status of older adults from seven countries where the mobility patterns of drivers and non-drivers were compared in terms of city and rural areas, weather, as well as their respective differences in the number of out-of-home places accessed and quality of life. Older adults participated in a semi-structured interview and completed four standardised instruments: the EQ-5D-5L, modified PULSES health profile, modified Transportation Questionnaire, and the Transport – Participation in Activities and Places Outside the Home. Results suggested inclement weather and place of residence negatively impacted out-of-home activities but did not increase use of public transportation. Drivers accessed more out-of-home activities than non-drivers, suggesting higher community participation among this group, and quality of life was generally high among all participants, but slightly higher for drivers. Findings indicate that a complex myriad of factors can influence community mobility in older adults and further investigations are needed to understand patterns of transport in later life, particularly with regard to those factors that promote and maintain transport mobility, and relationships between transport mobility, community participation and quality of life.
How does spirituality manifest in family caregivers of terminally ill cancer patients? A qualitative secondary analysis
Authors: Wikert Julia , Treutlein Max , Theochari Marianna , Bokemeyer Carsten , Oechsle Karin , Ullrich Anneke 
Published: March 2021

AbstractObjectiveConsidering the risk of spiritual distress among terminally ill patients, experts long agree that spiritual care has to be an integral component of palliative care. Despite this consensus, the role of spirituality among family caregivers remains largely unexplored. We aimed to describe how spirituality manifests in the lived experience of family caregivers (FCs) in a palliative care context.MethodAs part of a secondary analysis, data derived from two qualitative primary studies on FCs’ burdens and needs in the context of caring for a patient with a diagnosis of incurable cancer. Previously transcribed interviews were examined by means of a thematic analysis, transcending the focus of the primary studies to examine how spirituality arises and/or persists in the life of FCs from the time of diagnosis of incurable cancer up until bereavement.ResultsTwenty-nine narratives were explored and all included spirituality as a relevant theme. Analysis revealed four aspects associated with the presence of spirituality among FCs’ experiences: “Connectedness,” “Religious Faith,” “Transcendence,” “Hope,” and a fifth overarching aspect which we named “Ongoing integration of spiritual experience.” Spirituality appeared as a multilayered phenomenon and was shaped individually among FCs’ narratives.Significance of resultsIn view of the results, exploring and discussing spirituality and underlying experiences in the situation as an FC seems likely to widen the perspective on FCs’ problems and needs. Further research on spiritual needs among FCs of patients with incurable life-limiting cancer is deemed necessary.
Bill Content, Legislative Outcomes, and State-Level Resistance to National Policies
Authors: Callaghan Timothy , Karch Andrew 
Published: March 2021

AbstractRecently, scholars of the lawmaking process have urged their colleagues to devote more attention to the potential impact of bill content on legislative outcomes. Heeding their call, this paper builds an original dataset of over 5,000 pieces of state-level legislation addressing issues that span the ideological spectrum. It compares proposals that challenge the authority of the national government in a specific domain to proposals that lack federalism-related implications and finds that the former, all else being equal, make less legislative progress toward enactment. In addition, it categorizes the measures that resist national laws based on the specific nature of the challenge they pose. Its analysis finds that measures that are inconsistent with existing national law but work within the law’s legal framework make more legislative progress than measures that seek to nullify the national law or that vow not to cooperate with it. It also confirms that sponsor characteristics such as majority status, the number of cosponsors, institutional rules such as hearing requirements, and state-level factors like party control of the state legislature affect how much progress proposals make toward enactment. Thus, the paper demonstrates the importance of legislative content as an explanatory factor and sheds light on the nature of intergovernmental relations in the contemporary United States.
Mea Culpa? The Role of Data Collection in Public Officials Acknowledging Policy Failure
Authors: James Sarah 
Published: March 2021

AbstractState governments, often described as “laboratories of democracy,” design and implement many public policies, but this moniker also implies course correction when initial efforts fail. But how do states learn from failure? Existing hypotheses about policy learning and broad research capacity are insufficient. Using case studies of failed juvenile justice policies in Texas and Washington, I explore when failure acknowledgment occurs at all. I argue that a state’s bureaucratic capacity to gather data—distinct from its analytical capacity—is necessary for public officials to acknowledge failure, highlighting the impact of policy and institutional design on evidence-based policy making and policy corrections.