bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic roles of PYCR2 and ZBTB18 expression in tissues of colorectal carcinoma and Non-neoplastic tissues; an immunohstochemical study
Authors: Harb Ola , Elfeky Mariem A. , Wadea Fady M. , Elsayed Ahmed M. , Shorbagy Shereen El , Alattar Ahmed Z. , Amin Ahmed F. , Amin Mohamed Farouk , Almoregy Abdelwahab S. 
Published: October 2021

Abstract
Background: it will be important to detect novel biomarkers which are responsible for progression and spread of CRC for better evaluation of patients’ prognosis, better management and development of recent therapeutic targets. Pyrroline-5-carboxylate reductase 2 (PYCR2), in humans is encoded on chromosome 1q42.12. PYCR2 metabolic activity was linked to oncogenesis in many cancers. ZBTB18, a zinc finger transcriptional repressor was found to have tumor suppressor role and was found to be methylated in CRC.Detailed assessment of prognostic roles of PYCR2 and ZBTB18 CRC patients are not sufficiently studied. Aim of the study was to evaluate tissue protein expression of PYCR2 and ZBTB18 in CRC and adjacent non-neoplastic intestinal tissues to detect their roles in CRC carcinogenesis, progression and metastases. Patients and methods: After application of inclusion criteria, 60 CRC patients were included in the study. Tissue samples from tumor and adjacent non-neoplastic tissues of included patients were stained with PYCR2 and ZBTB18.Patients were followed up for about 30 months (range from 10-36 month). We correlate between markers expression, clinicopathological and prognostic parameters.Results: upregulation of PYCR2 and down regulation of ZBTB18 was found in CRC than adjacent non-neoplastic colonic mucosa (p= 0.026 and p<0.001 respectively). High expression of PYCR2 and low expression of ZBTB18 were positively correlated with large tumor size, higher grade, advanced tumor stage, presence of spread to lymph node and presence of distant metastases (p<0.001). High PYCR2 and low ZBTB18 expression were signifi­cantly associated with poor response to therapy (p = 0.008, 0.0.17 respectively), high incidence of progression and relapse recurrence (p=0.005), unfavorable OS rate (p=0.001).Conclusions: High expression of PYCR2 and low expression of ZBTB18 were independent predictors of CRC, progression, poor prognosis and unfavorable patient OS and PFS rates.
Risk Factors for One-Year Hospital Readmissions in Patients with Systemic Lupus Erythematosus
Authors: Chen Jinxia , Zhang Limin , Huang Liutao , Chen Shuxian , Xu Shuxian , Liu Huafeng 
Published: October 2021

Abstract
Objective: To reveal the characteristics and risk factors of systemic lupus erythematosus (SLE) patients with frequent readmission to intervene early and improve the quality of care during initial hospitalizations.Methods: This was a single-center, retrospective case-control study involving 521 hospitalized patients with SLE from January 2014 to December 2016 in the Affiliated Hospital of Guangdong Medical University.Results: A total of 521 patients were enrolled, including 400 patients who were hospitalized once and 121 patients who were hospitalized repeatedly, and 23.2% of the patients were readmitted within one year. The results showed that the age of onset (odds ratio [OR] 1.022, 95% confidence interval [CI] 1.007-1.036), serum albumin (OR 0.965, 95% CI 0.942-0.989), and cystatin C (OR 1.404, 95%CI 1.180 -1.670) were closely related to readmission. The most common causes of readmission were infections (52 cases, 27.08%), especially respiratory tract infections, and lupus activity or recurrence (45 cases, 23.4%).Conclusion: Special attention should be paid to SLE patients with older age of onset, low serum albumin levels, and high cystatin C levels to avoid infection and recurrence with the aim of reducing the hospital readmission rate.
Brownfield Redevelopment Query Model Based on Socioeconomic Conditions
Authors: Chen I-Chun , Yang Bo-Chieh 
Published: October 2021

Abstract
Redeveloping brownfields can be considered an important step in regional urban development. With breakthroughs in information technology, Taiwan has established a number of open databases, this study uses these open datasets of regional socioeconomic and environmental geo-information to develop a regional SDG map and screen suitable brownfield locations for redevelopment. This study designs Brownfield Redevelopment Query (BRQ) model that combines big data socioeconomic geographic information to link with sustainable potentiality for evaluating benefit-cost ratios (BCR). Land stakeholders can obtain useful information prior to brownfield investment. The flexible user interface design is useful to explore the outcomes of BCR (consolidation, internalities, and externalities) for four land-use scenarios (residential, industrial, commercial, and renewable energy facilities) of brownfield redevelopment. The brownfield redevelopment BCR is positively dominated by the operating profits in the reuse stage for two contaminated sites. Besides, the externalities BCR value of the studied cases is positive, particularly in converting the residential land if the site is located at level 4 and level 5 of the SDG map. Consequently, this study uses a large quantity of transparent information and flexible user interface design to develop a useful evaluation tool and to reduce the possible pitfalls associated with brownfield redevelopment for land stakeholders.
Evaluation of the FilmArray Meningitis/Encephalitis Panel for Detection of Pathogenic Microorganisms in Cerebrospinal Fluid Specimens
Authors: Hara Makoto , Ishihara Masaki , Nakajima Hideto 
Published: October 2021

Abstract
Background: Infectious meningitis and encephalitis are neurological emergencies that necessitate rapid diagnosis and treatment. Prompt initiation of empirical antimicrobials is common practice in suspected cases. However, swifter definite diagnosis and an earlier start of definitive treatment may improve outcomes. We compared the BioFire FilmArray Meningitis/Encephalitis (ME) Panel, a multiplex polymerase chain reaction test, with conventional standard methods of diagnosing infectious meningitis and encephalitis.Subjects and methods: We retrospectively studied 20 patients in whom meningitis or encephalitis was diagnosed according to clinical symptoms and laboratory findings between January 2018 and December 2019 at our institution. The results of pathogen diagnosis by the FilmArray ME Panel were compared with those of conventional methods.Results: The median age of the patients was 39 years (range, 23 to 85 years), and 13 (65%) were women. The FilmArray ME Panel identified the following pathogens: herpes simplex virus (HSV)-1 in two patients, HSV-2 in one, varicella-zoster virus (VZV) in four, Streptococcus pneumoniae in three, and Cryptococcus neoformans in one. This test detected additional pathogens in one patient with S. pneumoniae and in one with VZV, whereas the conventional methods did not. The median time to pathogen identification was 2 h with the FilmArray ME Panel but 4 days with conventional methods.Conclusion: Our findings suggest that the FilmArray ME Panel can detect and identify the most common pathogens faster and more sensitively than can conventional methods. This new method would thus help improve clinical outcomes through definitive diagnosis and treatment.
Anugerah yang Meresahkan: Menggumuli Teks-Teks Kekerasan di Perjanjian Lama
Authors: Fangidae Tony Wiyaret 
Published: October 2021

AbstractOld Testament readers tend to deselect or discredit texts that contain violent connotation. This creates a bad impression of the Old Testament. This article attempts to overcome the polemics about such texts within the Old Testament by offering a new theology of grace. The construction of grace is grounded on texts concerning love, justice, peace, and other words of positive values. As a conclusion, this article suggests violent-connotated texts as an unsettling grace.
AbstrakTeks-teks yang berbicara tentang kekerasan dalam Perjanjian Lama cenderung disisihkan atau diabaikan oleh pembaca. Hal itu memberi kesan buruk tentang Perjanjian Lama. Tulisan ini mencoba mencari solusi atas polemik teks-teks kekerasan di dalam Perjanjian Lama dengan menawarkan teologi anugerah yang baru. Konstruksi anugerah dilandasi oleh teks-teks yang berbicara tentang kasih, keadilan, kedamaian, dan kata-kata bernilai positif lainnya. Tulisan ini ditutup dengan mengonstruksi teks-teks kekerasan sebagai anugerah yang meresahkan.
Preparation of bio-absorbents by modifying licorice residue via chemical methods and removal of copper ions from wastewater
Authors: Yin Xiaochun , Zhang Nadi , Du Meixia , Zhu Hai , Ke Ting 
Published: October 2021

Abstract
In this paper, a series of bio-adsorbents (LR-NaOH, LR-Na2CO3 and LR-CA) were successfully prepared by modifying Licorice Residue (LR) with NaOH, Na2CO3 and citric acid, and were used as the adsorbents to remove Cu2+ from wastewater. The morphology and structure of bio-adsorbents were characterized by Fourier Transform Infrared, scanning electron microscopy (SEM), thermogravimetry (TG) and X-ray diffraction (XRD). Using static adsorption experiments, the effects of the adsorbent dosage, the solution pH, the adsorption time, and the initial Cu2+ concentration on the adsorption performance of the adsorbents were investigated. The results showed that the adsorption process of Cu2+ by the bio-adsorbents can be described by pseudo-second-order kinetic model and the Langmuir model. The surface structure of the LR-NaOH, LR-Na2CO3 and LR-CA changed obviously, and the surface-active groups increased. The adsorption capacity of raw LR was 21.56 mg/g, while LR-NaOH and LR-Na2CO3 significantly enhanced this value up to 43.65 mg/g and 43.55 mg/g, respectively. After four adsorption–desorption processes, the adsorption capacity of LR-NaOH also maintained about 73%. Therefore, LR-NaOH would be a promising adsorbent for removing Cu2+ from wastewater, and the simple strategy towards preparation of adsorbent from the waste residue can be a potential approach for use in the water treatment.
Total Knee Arthroplasty Conversion after Open-wedge High Tibial Osteotomy
Authors: Kusano Wataru , Mine Takatomo , Ihara Koichiro , Tominaga Yasuhiro , Kawamura Hiroyuki , Shinohara Michio , Kuriyama Ryutaro 
Published: October 2021

Background:
Open-wedge High Tibial Osteotomy (HTO) is an effective treatment for Osteoarthritis (OA) of the knee; however, postoperative changes due to HTO can make subsequent Total Knee Arthroplasty (TKA) technically difficult and can affect long-term survival.

Case Report:
Medio-lateral stability along with balanced flexion and extension gaps provides a good functional outcome.
A 71-year-old man underwent TKA conversion after open-wedge HTO 12 years earlier; the conversion was performed due to arthritic deterioration in the knee. Medial instability was noted because of poor ligament balancing. The residual medial instability was managed with a knee brace due to the unavailability of the constrained prosthesis. Management of persistent mediolateral instability persisting after soft tissue release and balancing ideally requires varus-valgus constraint.

Conclusion:
TKA conversion after open-wedge HTO requires a special technique and careful preparation before surgery.
Impacto de la descentralización fiscal en el desarrollo económico de Ecuador
Authors: Del Río Juan Antonio , Ochoa Rico María Salomé , Romero Subia José Fernando , Arencibia Montero Orlando 
Published: October 2021

La Descentralización Fiscal se ha convertido en una herramienta política, económica y social alrededor del mundo. Las transferencias de autoridad fiscal y recursos financieros a partir del gobierno central hacia los gobiernos subnacionales han forjado un camino seguro hacia el desarrollo. En el caso de Ecuador, a partir de la Constitución del 2008 se establecieron criterios para construir una nueva estructura política, administrativa y financiera, a través de la implementación de procesos descentralizadores. Por lo tanto, con base en la discusión teórica y empírica propuesta en la presente investigación, se ha planteado la hipótesis de que existe un impacto positivo de la descentralización fiscal en el desarrollo económico de Ecuador. Para el efecto, se ha realizado un análisis econométrico en Eviews 10, en un periodo de tiempo comprendido entre los años 2007-2015, sobre la base de un indicador económico propuesto para medir el crecimiento económico, denominado Valor Agregado Bruto, como variable dependiente, así también, un conjunto de indicadores considerados determinantes de descentralización fiscal, como variables independientes. Los datos obtenidos corresponden a 144 municipios, los resultados empíricos demuestran que existe un impacto positivo de la descentralización fiscal sobre el desarrollo económico de Ecuador.
Potencial evocado auditivo Mismatch Negativity em músicos adultos
Authors: Nascimento Lissandro Werlang do , Schwade Laura Flach , Didoné Dayane Domeneghini , Sleifer Pricila 
Published: October 2021

Introdução: Mismatch Negativity (MMN) é um exame objetivo que não depende da realização de tarefas nem da atenção do sujeito. Tem sido utilizado para estudar o processamento auditivo relacionado à detecção automática de mudanças auditivas. Objetivo: Analisar latências e amplitudes do MMN em músicos adultos e comparar os resultados com um grupo controle de não músicos normouvintes. Método: Estudo transversal e comparativo. A amostra foi composta por 69 sujeitos, 40 sujeitos não músicos (grupo controle) e 29 sujeitos músicos (grupo estudo) todos com no mínimo três anos de experiência musical e idades superiores a 18 anos. Todos realizaram avaliação auditiva periférica e o MMN. Resultados: A média das latências e amplitudes do grupo controle foram, respectivamente, 173,61ms (±49.80) e 4,25µV (±3.60) e do grupo estudo foram, respectivamente, 144,23ms (±17.58) e 5,12µV (±2.73). Houve diferença estatisticamente significante entre os grupos por orelha (p<0,05), sendo a média das latências e amplitudes do grupo estudo de 140,08ms na orelha direita e 148,37ms na orelha esquerda, e 4,83µV na orelha direita e 5,41µV na orelha esquerda. Conclusão: O grupo de músicos apresentou melhores resultados, como menor latência e maior amplitude do MMN, evidenciando melhor processamento do estímulo acústico em nível central.
An alternative algorithm for the n–Queens puzzle
Authors: Sacaluga David Luque 
Published: October 2021

Abstract
In this paper a new method for solving the problem of placing n queens on a n×n chessboard such that no two queens directly threaten one another and considering that several immovable queens are already occupying established positions on the board is presented. At first, it is applied to the 8–Queens puzzle on a classical chessboard and finally to the n Queens completion puzzle. Furthermore, this method allows finding repetitive patterns of solutions for any n.
IDENTIFICATION OF SUBSURFACE STRUCTURE USING SEISMIC REFRACTION METHOD AT JANTHO ACEH BESAR
Authors: Zikrilah Muhammad , Sugiyanto Didik , Rusydy Ibnu 
Published: October 2021

An identification of subsurface structure in the surrounding area of Aceh Besar regent’s office was conducted by using seismic refraction method. The aims of this study are to determine the velocity value between layers in order to describe thesubsurface layer model, to identify the types of rocks on each layer, and to analyze the depth of bedrock layer located in the subsurface. There are 4 tracks with spaces in between each geophone, and on each track, with the width of 3 m. The total spread on the track is 72 m and the farthest shoot point is 36 m from the farthest geophone point.
Impacto das declarações de Nova Delhi, Jomtien, Dakar e Incheon nas políticas públicas de educação
Authors: Berg Rosana da Silva , Votre Sebastião Josué 
Published: October 2021

Documentos internacionais que traçam metas para a educação de países em desenvolvimento são conhecidos como declarações. Essas declarações são documentos fundadores e têm impacto na educação, como fontes de propostas e como recursos práticos de ação. Neste trabalho, fazemos breve relato cronológico, apresentamos e analisamos cinco documentos: Jomtien e Nova Delhi, LDB 9394/96 e, posteriormente, Dakar e Incheon. Para isso, adotamos a metodologia da análise de conteúdo de Bardin (2011). O referencial teórico apoia-se em Votre (2019) para análise do discurso e Oliveira (2015) para políticas linguísticas. Os primeiros resultados das análises manifestam que o objetivo dos documentos é orientar as políticas públicas para educação dos países em desenvolvimento, a fim de executar o projeto de educação para todos estabelecido em Jomtien que foi se desdobrando ao longo dos anos até chegar a Incheon que orienta que a educação não pode deixar ninguém pra trás. A análise leva também a um exercício de autocrítica responsável, para os profissionais da linguagem que atuam com educação, no quadro brasileiro, uma vez que da leitura e releitura das declarações, emerge uma nova preocupação, relativa ao silenciamento e à proibição de uso das línguas de grupos minoritários, bem como de imigrantes, que são alijados de sua cultura, a pretexto de integração na cultura monolíngue dos países em que vivem.
Web-based Application Forecasting of Components and Tools for Practicum in Telecommunication Engineering Laboratory/ Workshop of State Polytechnic of Sriwijaya
Authors: Elmerillia Elmerillia , Lindawati Lindawati , Salamah Irma 
Published: October 2021

State Polytechnic of Sriwijaya is an Indonesian vocational institution that incorporates practical learning into all of its existing study programs. In each laboratory of the study program, students will find the supporting components and resources they need for practicum. Telecommunication engineering is one of them. Currently, the component retrieval and tool borrowing system is still manual, both in the retrieval and return stages, by filling out the given hard-file form sheet. Therefore, a web-based inventory monitoring application is required for laboratory technicians. The creation of this application implements the Prototype Method. The implementation of this method aims to make the application that is created to fit the needs of the user. This system helps laboratory technicians and Telecommunication Engineering students in the process of component retrieval and tool borrowing to be more organized and scheduled and can store reports in the form of soft-files. This information system can also be used by students to monitor the number of components and tools available in real-time. This application are also equipped with forecasting the number of practicum components to kwowing the needs of student practicum in the next year. Forecasting was created using the Weighted Moving Average method. Black box testing is carried out in each menu on the application and gives valid results so that the application can be used.
La fleur de lotus ou Nelumbo nucifera dans les mosaïques gréco-romaines
Authors: VASSAL Véronique 
Published: October 2021

Numerous mosaics from the Hellenistic and imperial periods with Nilotic decoration have been recorded, both in the West and in the East. Almost all of them have a vegetal decoration illustrating the flora of the Nile. Among this lush vegetation, the lotus is reproduced in various forms and it is worth studying some of these representations in detail. Some examples seem to be part of an Alexandrian tradition, but particularities may evoke the world of Pharaonic Egypt. We have endeavoured to highlight how the expression of these traditions in iconography has manifested itself as well as in the treatment of the decoration.
In the first instance, we thought it would be useful to go back over a few notions of botany and the characteristics of water lilies in Egypt. Different species are very similar, which leads to multiple risks of misunderstanding when using iconographic or literary sources.
In the second instance, we have tried to show how Greco-Roman mosaic artists rendered the different stages of the growth of these flowers through their art. The naturalistic aspect, very present in Hellenistic mosaics, seems to have changed during the imperial period. Does the lotus retain something of the earlier floral vision, when it adorned the pavements of the Roman provinces?
In the House of the Fauna in Pompeii, the mosaic of the Battle of Alexander and Darius decorated an exedra. The threshold, delimited by two Corinthian columns, was decorated with a mosaic consisting of several panels depicting scenes of life on the Nile, dating from the end of the 2nd century BC. These have been widely described and we have only focused here on the representation of lotus flowers. The illustration seems to visually describe the different stages of the flower’s life cycle. This is, in particular, the case as regards the Barberini mosaic in Préneste. The lotus sometimes appears from the front with its petals outspread. The nelumbo then consists of several corollae, the petals of which display shades of colour ranging from dark pink to light pink. This treatment is reminiscent of the fragment from the mosaic of the Canope baths, where a large nelumbo with two corollae unfolds in a circular composition.
Association patterns of seagrass with gastropods types in the intertidal zone of coastal waters, Suli village, Salahutu district, Ambon island
Authors: Tuaputty Hasan - , Kurnia Tri Santy , Wael Syahran 
Published: October 2021

Seagrass beds play an important role in coastal aquatic ecosystems and are one of the tidal areas that are widely used by the community as a forum for the interests of educational institutions in research activities, conservation of various marine biota. Ecologically, the seagrass ecosystem acts as a shelter and a place to eat various marine biota, including gastropods. The purpose of this research is not only to explore the diversity of gastropods, but also to examine the interactions of gastropod species, both between the same species and between different species in a community of seagrass ecosystems. The diversity index calculation shows the diversity index value H = 3.982 > 3, this means that the diversity of gastropod species is quite good. The results of the basic analysis obtained the calculated X2 value of 0.656, > X2 table with a significant level of 0.05%. There is an association relationship between seagrass ecosystems and the types of gastropods that live in seagrass ecosystems in coastal waters of Suli Village, Ambon.

Keywords: Gastropods, Seagrass meadows, Association