bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bupropion for Major Depressive Disorder or Persistent Depressive Disorder (Dysthymia)
Authors: MacDonald Erika , Horton Jennifer 
Published: September 2021

Direct and indirect evidence from 6 systematic reviews did not demonstrate a difference in treatment response or remission rates, or functional outcomes, with bupropion as compared to other antidepressants in adults with major depressive disorder.
Direct and indirect evidence from 5 systematic reviews did not demonstrate a difference in overall adverse events, overall withdrawals, or withdrawals due to adverse events apart from a possible decreased risk of withdrawal due to adverse events with vortioxetine in a single indirect comparison.
Direct and indirect evidence from 2 systematic reviews supports that the risk of sexual dysfunction may be lower with bupropion than other antidepressants (escitalopram, paroxetine, sertraline, and fluoxetine), while 1 systematic review showed no significant difference in sexual function scores between bupropion and venlafaxine.
There is limited evidence supporting the cost-effectiveness of bupropion to augment citalopram, and dominance of vortioxetine compared to bupropion, for major depressive disorder with inadequate response to initial therapy.
There is a lack evidence surrounding the comparative clinical or cost-effectiveness of bupropion in dysthymia.
Interferon Gamma Release Assay for Identifying Latent Tuberculosis Infection in People With Bacillus Calmette-Guérin Vaccination
Authors: Brett Kendra , Severn Melissa 
Published: September 2021

In people who have been vaccinated with Bacillus Calmette-Guérin, the interferon gamma release assay appears to be related to fewer diagnoses for latent tuberculosis infection, fewer prescriptions of preventive tuberculosis therapy, and no difference in the number of active TB cases compared to the tuberculin skin test (findings based on 1 [non-randomized study] of low quality).
No evidence-based guidelines were found regarding the identification of latent tuberculosis infection in people with previous Bacillus Calmette-Guérin vaccination.
Models of Care for Chronic Pain
Authors: Brett Kendra , MacDougall Danielle 
Published: September 2021

For chronic pain, 1 hub-and-spoke model and 4 stepped care models for the delivery of care in Canada and internationally were identified and described. No information was found on the use of the Oncology Care Model for chronic pain.
For other medical conditions, 9 stepped care models, 5 hub-and-spoke models, and the Oncology Care Model for the delivery of care in Canada and internationally were identified and described.
Patient-related outcomes used to evaluate the effectiveness of models of care for chronic pain include pain measures (e.g., intensity, duration), psychosocial outcomes (e.g., anxiety, depression), functional outcomes (e.g., disability, employment status), and health care utilization (e.g., opioid prescriptions, health care visits).
Various barriers and facilitators to providing care for patients with chronic pain were identified in the consultations and the literature. The most common factors that influenced the care provided to patients with chronic pain pertained to funding, support, and collaboration from the government and locally; having a centralized intake and referral system; and leveraging existing resources.
There appears to be considerable variation in the models of care used to address the care needs of patients with chronic pain. In Canada, there are provincial, regional, and local models, and local programs; some regions do not have a formalized approach for the provision of care for chronic pain patients.
Laxatives and Erectile Dysfunction Medications to Treat Side Effects of Opioid Agonist and Methadone Maintenance Therapy
Authors: Khangura Sara D. , Ryce Andrea 
Published: September 2021

Opioid agonist and methadone maintenance therapies are essential medical interventions for effectively managing opioid use disorder. However, side effects, including constipation and erectile dysfunction can compromise treatment adherence and increase the risk of relapse.
No studies or guidelines describing the clinical effectiveness or recommendations for the use of laxatives or erectile dysfunction medications in the treatment of constipation or erectile dysfunction in patients undergoing OAT or MMT were identified.
Research is needed to understand the clinical effectiveness and inform guidance concerning the treatment of constipation with laxatives and the use of medications indicated for erectile dysfunction.
Fedratinib (Inrebic)
Authors: Team Reimbursement 
Published: September 2021

Clinical evidence suggests that the JAK inhibitor Inrebic should be reimbursed as a treatment option for adults with myelofibrosis who cannot take or tolerate Jakavi. Inrebic cannot be prescribed to those who progress on Jakavi.
There is insufficient evidence to justify a cost premium for Inrebic over other JAK inhibitors reimbursed for the treatment of myelofibrosis.
If Inrebic is not reimbursed by public payers, best available therapy will be the only other treatment option for patients who cannot take Jakavi.
Dupilumab (Dupixent)
Authors: Team Reimbursement 
Published: September 2021

Clinical evidence suggests that Dupixent should be reimbursed to treat patients aged 12 years and older with severe asthma and with a type 2 or eosinophilic phenotype or oral corticosteroid–dependent asthma.
Economic evidence suggests that a 93% price reduction is needed to ensure Dupixent is cost-effective at a $50,000 per quality-adjusted life-year threshold relative to standard of care alone.
Cost-effectiveness versus other biologics is unknown.
CADTH was unable to estimate the budget impact due to a high degree of uncertainty.
Neo sufism and the concept of seven dignities of Muhammad Nafis al-Banjari
Authors: Arifin Miftah 
Published: September 2021

This study aims to describe how Muhammad Nafis al-Banjari’s position in transmitting doctrine of wahdat al-wujud in Indonesia. The research used a descriptive form with a qualitative approach and historical method. This study through four stages, namely heuristics, source criticism, interpretation and presentation. Nafis al-Banjari has played a very important role in transmitting wahdat al-wujud thought in Indonesia. Firstly, the thought of wahdat al-wujud tends to be difficult to be understood, but in the next time, it can be explained more easily through the concept of the seven dignities. Nafis al-Banjari then explained the concept The Book of Tuhfah al-Mursalah written by al-Burhanpuri in in his primary book namely Durr al-Nafis.
ANALISIS KESALAHAN PENGGUNAAN TANDA BACA PADA TEKS BIOGRAFI SISWA
Authors: Bahrum Eka Aprilia , Zain Suardi , Ecca Suleha , Kasman Nuraini 
Published: September 2021

Penelitian ini merupakan penelitian kualitatif deskriptif yang betujuan untuk mendeskripsikan kesalahan penggunaan tanda baca yang ditemukan pada teks biografi yang ditulis oleh siswa kelas X SMA Muhammadiyah Pangsid Kecamatan Maritengangae Kabupaten Sidenreng Rappang. Data diperoleh melalui wawancara, tes tertulis, dokumentasi dan klasifikasi data kemuddian dianalisis dengan teknik pengodean (cooding), pendeskripsian tiap-tiap kesalahan, pengklasifikasian dengan menggunakan persentase, dan membuat kesimpulan mengenai kesalahan terbesar sampai yang terkecil. Kesalahan terbesar pada penggunaan tanda baca yang ditemukan pada tulisan siswa yaitu kesalahan pada penghilangan tanda titik di akhir kalimat pernyataan dengan persentase 37,77%.
THE PUBLIC SPEAKING TRAINING ACTIVITIES FOR PROFESSION OF PSYCHOLOGY
Authors: Hairunnisa Hairunnisa , Nurrahim Irsalinda Wesa , Syahidah Shiba Syahidah , Rifaldi Ahmad Naufal , Al-Hadad Muhammad Naufal 
Published: September 2021

Mahasiswa S1 Psikologi merupakan bagian dari masa depan bangsa yang diharapkan mampu memberikan teladan dalam kepemimpinan di masyarakat luas. Setiap prilaku dan ucapan yang disampaikan diharapkan menjadi contoh dan teladan yang baik untuk masyarakatnya. Agar hal tersebut terlaksana dengan baik maka diperlukan dan menjadi keharusan untuk dibekali keterampilan berbicara yang baik dan santun, sehingga mereka mampu menjadi tenaga-tenaga pamong yang handal, kompeten, tangguh dan professional dalam menangani permasalahan-permasalahan masyarakat dan memberikan pelayanan kepada public. Strategi yang digunakan dalam kegiatan pelatihan Public Speaking untuk profesi psikologi ini ialah menggunakan Focus Group Discussion (FGD). FGD itu sendiri ialah diskusi terfokus dari suatu grup dalam membahas suatu masalah tertentu. Diharapkan setelah ini Mahasiswa mendapatkan manfaat secara komprehensif dalam keterampilan dasar dan lanjutan untuk penerapan kepiawaian berbicara yang baik dan santun dihadapan public sehingga menjadi motivator/interest rekan sejawat di lingkungan kampus.

Kata Kunci : Profesi Psikologi, Ilmu komunikasi, Public Speaking
Abstract:
Undergraduate Psychology students are part of the nation's future who are expected to be able to provide role models in leadership in the wider community. Every behavior and speech conveyed is expected to be a good example and role model for the community. In order for this to be carried out properly, it is necessary and imperative to be equipped with good and polite speaking skills, so that they are able to become reliable, competent, tough and professional civil servants in dealing with community problems and providing services to the public. The strategy used in the Public Speaking training for the psychology profession is to use a Focus Group Discussion (FGD). FGD itself is a focused discussion of a group in discussing a particular problem. It is hoped that after this students will get comprehensive benefits in basic and advanced skills for the application of good and polite speaking skills in front of the public so that it becomes a motivator / interest for colleagues in the campus environment.

Keyword: Profession Psychology, Communication Studies, Public Speaking
Low hydrological connectivity after summer drought inhibits DOC export in a forested headwater catchment
Authors: Blaurock Katharina , Beudert Burkhard , Gilfedder Benjamin S. , Fleckenstein Jan H. , Peiffer Stefan , Hopp Luisa 
Published: September 2021

Abstract. Understanding the controls on event-driven dissolved organic carbon (DOC) export is crucial as DOC is an important link between the terrestrial and the aquatic carbon cycles. We hypothesized that topography is a key driver of DOC export in headwater catchments because it influences hydrological connectivity, which can inhibit or facilitate DOC mobilization. To test this hypothesis, we studied the mechanisms controlling DOC mobilization and export in the Große Ohe catchment, a forested headwater in a mid-elevation mountainous region in southeastern Germany. Discharge and stream DOC concentrations were measured at an interval of 15 min using in situ UV-Vis (ultraviolet–visible) spectrometry from June 2018 until October 2020 at two topographically contrasting subcatchments of the same stream. At the upper location (888 m above sea level, a.s.l.), the stream drains steep hillslopes, whereas, at the lower location (771 m a.s.l.), it drains a larger area, including a flat and wide riparian zone. We focus on four events with contrasting antecedent wetness conditions and event size. During the events, in-stream DOC concentrations increased up to 19 mg L−1 in comparison to 2–3 mg L−1 during baseflow. The concentration–discharge relationships exhibited pronounced but almost exclusively counterclockwise hysteresis loops which were generally wider in the lower catchment than in the upper catchment due to a delayed DOC mobilization in the flat riparian zone. The riparian zone released considerable amounts of DOC, which led to a DOC load up to 7.4 kg h−1. The DOC load increased with the total catchment
wetness. We found a disproportionally high contribution to the total DOC
export of the upper catchment during events following a long dry period. We
attribute this to the low hydrological connectivity in the lower catchment
during drought, which inhibited DOC mobilization, especially at the
beginning of the events. Our data show that not only event size but also
antecedent wetness conditions strongly influence the hydrological
connectivity during events, leading to a varying contribution to DOC export
of subcatchments, depending on topography. As the frequency of prolonged
drought periods is predicted to increase, the relative contribution of
different subcatchments to DOC export may change in the future when
hydrological connectivity will be reduced more often.
Vers des epousailles economiques du tourisme, du developpement et de l’environnement ; A travers les paiements pour services environnementaux
Authors: LEHMER Oumaima , ELABBADI Abderrazak , EZAIDI Abdlkrim 
Published: September 2021

Après le coup d’envoi des chantiers de développement au Maroc, le tourisme est un secteur qui a été mis en exergue avec une certaine solennité. Il a été considéré comme étant l’un des pilotis des ressources économiques et la machine motrice du développement. En effet, le secteur a renouvelé ses stratégies managériales en définissant des objectifs très ambitieux qui permettent la consolidation et la mise en relief de différents types de tourisme, notamment le durable, le rural et le tourisme de nature.
Ces nouveaux chantiers préconisés ont été pris en considération après les nouvelles envergures qu’a connues le monde, telles que la valorisation du patrimoine culturel, la protection du patrimoine naturel et de l’environnement, les nouvelles destinations rurales… (etc). De l’idée de faire fondre les barrières entre ces différentes considérations, de vouloir participer à la gestion touristique de notre pays et d’attirer l’attention vers les lieux naturels à attraits touristiques ; nous nous somme emportés par l’idée de loger le tout sous la même toiture et c’est là où nous sommes parvenus aux Paiements pour Services Environnementaux (PSE). Notre projet est la définition d’un fond de PSE permettant la préservation, la sauvegarde et la valorisation des sites naturels à caractère touristique, il verra jour à Tafraout/Ameln. Une région appartenant à la Réserve de Biosphère de l’Arganeraie (RBA), qui offre des ressources d’exception au niveau géographique et socioculturel ainsi que des potentialités naturelles, lui permettant de devenir une destination de tourisme durable et d’écotourisme. L’instauration d’un concept PSE dans cette région prendra la forme d’un financement de système de préservation, de sauvegarde et de promotion, qui aura pour buts de: consolider les efforts de gestion et de management déployés par les acteurs dans le sens de l’environnement, de la nature et du tourisme; d’allouer le financement nécessaire aux frais de gestion et de combler les insuffisances de financement de l’état au profit de la valorisation, la structuration et la préservation des sites naturels touristiques. Toutefois, ce projet fait remonter une panoplie d’interrogations ; Quel sera le montant de ce financement ? Pour quelle démarche de sauvegarde ? Qui en sera le bénéficiaire ? Est-ce que cette nouvelle méthode managériale sera efficiente ? Tant d’autres énigmes ont été résolues dans notre travail de recherche, cet article fera le tour des enquêtes, des études de terrain et des collaborations avec les parties prenantes qui nous ont permises de confectionner notre modèle PSE.
Dynamics of the meromorphic families $f_\lambda=\lambda \tan^pz^q$
Authors: Chen Tao , Keen Linda 
Published: September 2021

This paper continues our investigation of the dynamics of families of transcendental meromorphic functions with finitely many singular values all of which are finite. Here we look at a generalization of the family of polynomials $P_a(z)=z^{d-1}(z- \frac{da}{(d-1)})$, the family $f_{\lambda}=\lambda \tan^p z^q$. These functions have a super-attractive fixed point, and, depending on $p$, one or two asymptotic values. Although many of the dynamical properties generalize, the existence of an essential singularity and of poles of multiplicity greater than one implies that significantly different techniques are required here. Adding transcendental methods to standard ones, we give a description of the dynamical properties; in particular we prove the Julia set of a hyperbolic map is either connected and locally connected or a Cantor set. We also give a description of the parameter plane of the family $f_{\lambda}$. Again there are similarities to and differences from the parameter plane of the family $P_a$ and again there are new techniques. In particular, we prove there is dense set of points on the boundaries of the hyperbolic components that are accessible along curves and we characterize these points.
condición tecno-ecológica. Heidegger ante los nuevos post-humanismos
Authors: Sandoval Rodrigo Y. 
Published: September 2021

Muchas de las reflexiones contemporáneas sobre ecología parten del cuestionamiento de la excepcionalidad del ser humano. Se busca de esta manera el distanciamiento de todo antropocentrismo y, en consecuencia, un marco conceptual ―post-humanista‖. El rol de Martin Heidegger en la búsqueda de alternativas al humanismo es reconocido, particularmente, por su rechazo al ―antropocentrismo‖ de Sartre. Sin embargo, mientras muchos post-humanismos ven en la tecnología un factor positivo en el descentramiento de lo humano, son conocidas las críticas heideggerianas a la técnica y su comprensión de ésta como parte del mismo movimiento metafísico (y antropocéntrico) moderno. En lugar de tomar en cuenta sus textos sobre la técnica, en este artículo se explora la relación de Heidegger con los post- humanismos contemporáneos a partir de la analítica existencial del Dasein. En primer lugar, se considera la situación tecnocientífica actual, siguiendo a autores como Wiener, Haraway y Latour. En segundo lugar, se evalúa la relación entre Dasein, cíborg y animal, a partir de las lecturas heideggerianas de Hubert Dreyfus (What Computers Can’t Do) y Steven Crowell (We Have Never Been Animals).
Much of the contemporary thought about ecology begins with the questioning of the human exceptionality. By means of this, anthropocentrism is rejected and replaced by a ―post-humanist‖ framework. In this context, Martin Heidegger‘s oeuvre is credited for its search of alternatives to humanism, particularly because of its rejection of Sartre‘s ―anthropocentrism‖. However, while post- humanisms tend to behold the role of technology positively, Heidegger‘s critiques to the technique as a consequence of the same metaphysical and anthropocentric movement are widely known. Instead of considering the common Heideggerian texts about technique, in this paper I explore the relationship between Heidegger and contemporary post-humanisms from the perspective of his existential analytic. In the first place, I will briefly describe the contemporary techno-scientific context, following the insights of Wiener, Haraway and Latour. In the second place, I will consider the relationship between Dasein, cyborgs and animals, discussing the Heideggerian interpretations of Hubert Dreyfus (What Computers Can’t Do) and Steven Crowell (We Have Never Been Animals).
Deberes de caridad, deberes de justicia y la creación del otro en la tradición kantiana
Authors: Sanchez-Perez Jorge H. 
Published: September 2021

Este artículo sostiene que hay problemas importantes en la tradición kantiana, en la medida en que existe una tendencia persistente a atribuir valor intrínseco basado en la existencia de capacidades cognitivamente relevantes. Además, se argumenta que después de un análisis de la obra de Kant, la exclusión de seres moralmente relevantes es una inclinación prevalente de la tradición. El trabajo de Rawls es utilizado para mostrar cómo, del racismo, el proyecto kantiano pasa al capacitismo. En la conclusión, se demuestra que incluso una versión más contemporánea y abierta de la tradición kantiana, como la defendida por Korsgaard, sigue vinculada a los mismos problemas que las formulaciones anteriores de la tradición.
In this paper, there are important problems in the Kantian tradition that are argued, insofar as there is a persistent tendency to attribute intrinsic value based on the existence of cognitively distinct capacities. Furthermore, it is argued that after an analysis of the work of Kant the exclusion of morally relevant beings is a prevalent inclination of the tradition. The work of Rawls is used to show how from racism, the project moves on to ableism. In the conclusions, is showed that even a more contemporary and open version of the Kantian tradition, such as the one defended by Korsgaard, is still bound to the same problems as the previous formulations of the tradition.
Tingkat Kepatuhan Tim Bedah Terhadap Prinsip Asepsis Di Ruang OK IGD RSUP Sanglah Denpasar
Authors: Gede Yenny Apriani Desak 
Published: September 2021

Latar belakang dan tujuan: Asepsis adalah keadaan bebas dari mikroorganisme penyebab penyakit. Oleh karena itu, perlu dilakukan upaya melalui teknik asepsis. Teknik asepsis adalah segala upaya yang dilakukan untuk mencegah masuknya mikroorganisme ke dalam yang kemungkinan besar akan mengakibatkan infeksi. Tindakan asepsis ini bertujuan untuk mengurangi atau menghilangkan mikroorganisme yang terdapat pada permukaan benda hidup atau benda mati. Tindakan ini meliputi aseptis, desinfektan dan sterilisasi. Penelitian ini bertujuan untuk mengetahui tingkat kepatuhan tim bedah terhadap prinsip asepsis di ruang OK IGD RSUP Sanglah Denpasar.
Metode: Desain penelitian ini adalah deskriptif. Populasi dalam penelitian ini adalah adalah semua tim bedah yang sudah dirata-ratakan dengan jumlah 24 responden, dengan tehnik total sampling. Data dikumpulkan dengan metode observasi.
Hasil: Didapat bahwa dari 24 responden tim bedah, sebagian besar responden yang tidak patuh sebanyak 13 orang (54,2%) dan sebagian kecil responden yang patuh sebanyak 11 orang (45,8%). Simpulan: Prinsip asepsis yang paling sering diterapkan oleh tim bedah bedah yaitu pada alat pelindung diri. Prinsip asepsis yang paling sering tidak diterapkan oleh tim bedah bedah yaitu (8%) penggunaan sepatu boot dan prilaku menyentuh area pinggang kebawah.
Perbedaan Pengetahuan Remaja Putri Sebelum Dan Sesudah Diberikan Penyuluhan Tentang Fluor Albus Di SMP Negeri 3 Penebel
Authors: Ariyanti Kadek Sri , Winangsih Rini , Firsia Sastra Putri Desak Made 
Published: September 2021

Background and purpose: Adolescence is a period of transition from childhood to adulthood. The problems facing adolescents are often related to reproductive health, one of which is fluorine albus. Many teenagers do not care about the fluoride of albus despite the enormous impact on women's reproductive health. One reason is the lack of knowledge about fluorine albus. Based on KISARA data there are 90.91% of girls in Denpasar City do not know the cause of fluorine albus. The purpose of this study was to determine differences in knowledge of young women before and after being given counseling about fluor albus.
Method: The research design used was pre-experimental with one group pretest posttest design using 70 respondents taken by stratified random sampling. The results showed that the average score of adolescent girls' knowledge about fluor albus before being given counseling was 11.56 and after counseling was 14.23. There was an average increase in knowledge of 2.67.
Results: Statistical test result using wilcoxon test get value p = 0.000 so that hypothesis accepted.
Conculusion: It can be concluded that there is difference of adolescent knowledge about fluorine albus before and after given counseling.