bluuebunny/crossref_metadata_2025_split huggingface dataset:
BNO 1095, a Standardized Dry Extract from the Fruits of Vitex agnus-castus, Impairs Angiogenesis-related Endothelial Cell Functions In Vitro
Authors: Bischoff-Kont Iris , Brabenec Laura , Ingelfinger Rebecca , Nausch Bernhard , Fürst Robert 
Published: February 2021

AbstractBNO 1095, a standardized dry extract from the fruits of Vitex agnus-castus, represents an approved herbal medicinal product for the treatment of premenstrual syndrome. Angiogenesis, the formation of new blood vessels from pre-existing capillaries, plays a major role in physiological situations, such as wound healing or tissue growth in female reproductive organs, but it is also of great importance in pathophysiological conditions such as chronic inflammatory diseases or cancer. Angiogenesis is a highly regulated multi-step process consisting of distinct key events that can be influenced pharmacologically. Few studies suggested anti-angiogenic actions of V. agnus-castus fruit extracts in in vivo and ex vivo models. Here, we provide for the first time profound in vitro data on BNO 1095-derived anti-angiogenic effects focusing on distinct angiogenesis-related endothelial cell functions that are inevitable for the process of new blood
vessel formation. We found that V. agnus-castus extract significantly attenuated undirected and chemotactic migration of primary human endothelial cells. Moreover, the extract efficiently inhibited endothelial cell proliferation and reduced the formation of tube-like structures on Matrigel. Of note, the treatment of endothelial cell spheroids almost blocked endothelial sprouting in a 3D collagen gel. Our data present new and detailed insights into the anti-angiogenic actions of BNO 1095 and, therefore, suggest a novel scope of potential therapeutic applications of the extract for which these anti-angiogenic properties are required.
Are Absence and Limbic Seizures Mutually Exclusive?: An Experimental Approach to Enigmatic Clinical Concept
Authors: Onat Filiz Yılmaz , Eşkazan Esat 
Published: February 2021

AbstractThe impressive advances in the several disciplines including neurophysiology, molecular biology, neuroimmunology, neurogenetics, neuroimaging, and neuropharmacology of epilepsies have been stimulating a mutual interaction among basic scientists, clinicians, and professionals from other disciplines, leading to the identification of clinical questions and then the design of basic science paradigms to test enigmatic clinical issues. Based on a clinical observation that the coexistence of genetic (idiopathic) generalized typical absence and mesial temporal lobe epilepsy in the same patient is extremely rare and debatable, we addressed the rare coexistence in the same individual, designed an experimental approach to test the validity of this clinical concept and to study the underlying mechanisms involved. Here we presented evidence of a mutual cross-interaction in the circuits involved in typical absence and temporal lobe epilepsy. This article delineates a phenomenological picture and comprehends a theoretical understanding of a mutual cross-interaction in typical absence as a representative of genetic generalized epilepsies and limbic epilepsy in which seizures often start from the mesial temporal lobe.
A Variant in SLC25A4 Leads to Mitochondrial DNA-Depletion Syndrome-12A Causing Neonatal Hypotonia and Hypoventilation
Authors: Sanghvi Kishore Pratap , Bajaj Shruti , Mirani Sonal 
Published: February 2021

AbstractCongenital hypotonia and hypoventilation is a rare association. We report a rare case of a female newborn with poor respiratory drive, ventilator dependency, severe hypotonia, cardiomyopathy, and premature death. Clinical-exome-sequencing revealed SLC25A4-related mitochondrial deoxyribonucleic acid (DNA) depletion syndrome-12A (cardiomyopathic type). This syndrome is apparent at birth and carries a poor prognosis.
Exploring linguistic features, ideologies, and critical thinking in Chinese news comments
Authors: Gao Yang , Zeng Gang 
Published: February 2021

AbstractThis study explores linguistic features, ideological beliefs, and critical thinking in news comments, which are defined as the comments from readers to news posts on social media or platforms. Within the overarching framework of critical discourse analysis, a sociocognitive approach was adopted to provide detailed analyses of the studied constructs in sampled news comments. In terms of the data collection and analysis, sampled social media, news columns, and news comments were selected, and then 19 college students were interviewed for their responses to different news topics. The primary findings of the study include: (1) personal and social opinions are representations of ideological beliefs and are fully presented through news comments, (2) these personal and social ideological beliefs may diverge or converge due to critical thinking, (3) critical thinking helps commenters form their personal and social ideologies, and then helps them choose the linguistic forms they believe fit their news comments, (4) news topics, however, vary in informing commenters’ critical thinking ability. Finally, a sociocognitive model for studying linguistic forms, ideologies, and critical thinking was proposed in the study.
Experimental and numerical research on a novel underwater launching method with high efficiency and low resistance
Authors: Zhang Xinwei , Yu Yonggang 
Published: February 2021

This paper describes an experimental and a numerical study of a recently developed high-efficiency, low-resistance launching method for an underwater launcher. The so-called gas-curtain launch method overcomes the problems of poor safety and low muzzle velocity in traditional fully submerged launchers. By introducing part of the gas inside the chamber to the front of the projectile, the water inside the barrel will be driven out. A low-resistance gas passage is then provided for projectile motion in the bore, thus delivering better interior ballistics performance than that in fully submerged launchers. Experiments are carried out using a 12.7-mm underwater launcher. A pressure sensor is used to record the chamber pressure, and high-speed video recordings allow the projectile motion around the muzzle to be determined. The experimental results show that the muzzle velocity is 172.8 m/s and the maximum chamber pressure reaches 116.0 MPa in a fully submerged launch, compared with a maximum chamber pressure of only 41.8 MPa and a muzzle velocity of 177.5 m/s when the gas-curtain launch method is adopted. The significant drag reduction effect of the gas-curtain launch greatly improves the interior ballistics performance, reducing the maximum chamber pressure by about 64.1% while retaining a similar muzzle velocity. Following the experiments, a numerical model is established and simulations are performed under various ventilation mass rates. The results clarify the drag reduction mechanism and the partial characteristics of the flow field in the gas-curtain launch.
Pattern formation and polarity sorting of driven actin filaments on lipid membranes
Authors: Sciortino Alfredo , Bausch Andreas R. 
Published: February 2021

Significance
Pattern formation processes in active systems give rise to a plethora of collective structures. Predicting how the emergent structures depend on the microscopic interactions between the moving agents remains a challenge. By introducing a high-density actin gliding assay on a fluid membrane, we demonstrate the emergence of polar structures in a regime of nematic binary interactions dominated by steric repulsion. The transition from a microscopic nematic symmetry to a macroscopic polar structure is linked to microscopic polarity sorting mechanisms, including accumulation in wedge-like topological defects. Our results should be instrumental for a better understanding of pattern formation and polarity sorting processes in active matter.
Non-destructive measurement of leaf area and leaf number of hydroponic pak-choy plants (Brassica rapa)
Authors: Nasution I S , Satriyo P , Ichwana  , Yolanda S , Alma A 
Published: February 2021

Abstract
Leaf area and leaf number is an important factor in many agronomic and plant physiological studies. The measurements are commonly obtained by destructive and time consuming via laboratory. Therefore, there is a trend in utilizing fast and non-destructive methods to estimate leaf area and leaf number. The aim of this study was to estimate leaf area and leaf number of pak choy (Brassica rapa) under field condition. For this purpose, 180 pots of pak choy plants were captured. Afterward, the images were analysed via image processing. Distance transform-watershed segmentation was used to extract and to separate every leaf from its background. The area of each leaves were estimated according to the pixel values obtained. The area of leaves also compared to the ImageJ measurement. The number of extracted leaves was evaluated according to precision, recall, and f-measure calculation. In conclusion, our system achieves a good performance for minimal occlusion leaves and provides quick and non-destructive method. This method could potentially be applied to design phenotyping system in the greenhouse even for small scale companies.
Chemical and sensory properties of local Aceh rice (Oryza sativa L.) M4 mutant resulting from Gamma-ray irradiation
Authors: Hayati R , Efendi  
Published: February 2021

Abstract
The chemical characteristic of Aceh local rice (Oryza sativa L.) is largely determined by the moisture content, protein, ash and amylose. On the other hand, sensory indispensable to determine the level of acceptance of a product. This study aims to determine chemical analysis and sensory of Aceh local rice mutant M4 from gamma-ray irradiation results. The results showed that M4 mutant rice had a very significant effect on the chemical characteristic, amylose and protein, and significantly affected to the ash content. The best amylose content was the USK-Snb-RGO-238-063-057e-217 strain, while the protein content in rice was USK-Snb-RGO-238-094-088j-140 and the best ash content was USK-Snb-RGO-238- 016- 057d-106. The Aceh local rice mutant M4 has a significant effect on inner color, outer color, texture and overall acceptance and has a significant effect on the shape of rice. The rice received by the panelists, namely rice USK-Snb-RGO-238-063-057e-217.
Chemical compounds identification of Rice cultivars in West Sumatra
Authors: Makky M , Santosa  , Cherie D , Putri R E , Hasan A 
Published: February 2021

Abstract
In West-Sumatra, rice farming commonly uses five significant cultivars, namely Simauang; Randa Pulau; Bakwan; Junjuangan; and Mundam. They are superior in yields and adaptable to the local climate. In this study, the chemical properties of five cultivars were investigated to identify the composition of protein, carbohydrate, ash, and moisture content. Furthermore, the effects of heat exposure to rices were observed as well, where products typically untreated when being stored. The research investigated how heat exposure may influence shelf life and rice quality. Results show that there are significant differences in chemical contents that occur due to differences in cultivars, storage treatment, and mechanical damage. The most chemical composition that changed when given treatment was Mundam and Simaung cultivars. The chemical composition that changed in Mundam cultivar is MC, Fat, and, Carbohydrate while in Simaung Fat, Ash, and Carbohydrate. Before giving heat treatment, Mundam rice contained the highest and lowest protein 9,617% and 79.37%. Simauang rice has low protein with a high carbohydrate of 6,343% and 81,472%. After giving heat treatment, the protein and carbohydrate of the Mundam changed to 10.207% and 78.666%. Simaung's protein did not change but protein, 6.284%, and 81.541% for carbohydrates. Carbohydrate has changed due to size and type of cultivar. The protein has changed due to cultivar influence, treatment, and size.
Quality study of dried Peda fish using a greenhouse effect vent dryer
Authors: Agustina R , Mustaqimah  , Nurba D , Yasar M , Itawarnemi  
Published: February 2021

AbstractThe purpose of this study was to examine the physical and chemical characteristics of peda Tenggiri fish. Peda is a traditional processed fish product that is made by salting and then followed by fermentation. Types of fish commonly made peda include Tenggiri fish. The method used in this research was experimental and the parameters analyzed were air content, salt content, acid insoluble ash, and organoleptic. The results obtained from the initial water content of T enggiri fish reached 3 7%, it can be denied that the water content of dried peda fish in Lhokseudu village has reached SNI (8273: 20016). Based on research, the initial salt content in Tenggiri fish ranges from 3.02%, the proportion that meets the Standard National Indonesian (SNI) so that it is still safe to use. The acid-insoluble ash content of Tenggiri fish reached 5.26% during the 23-hour drying process, the acid insoluble ash content increased, therefore the acid insoluble ash content did not meet the SNI standard.
The quality of goat milk due to the level of Lactobacillus plantarum and different heating temperature
Authors: Yurliasni  , Novita C I , Hanum Z , Wajizah S , Munandar R 
Published: February 2021

Abstract
A research has been conducted on the utilization of Lactobacillus plantarum and different heating temperatures on the quality of fermented goat milk The characteristic of milk which is easily damaged requires an effort of good management, one of them is through the technology of heating and fermentation. The research was done through completely randomized factorial design in which there were two treatment given, including a1 = pasteurization (temperature of 72° C for 15 seconds), a2 = sterilization (temperature of 121° C for 1 second), and level of Lactobacillus plantarum (factor B), b1
(L. plantarum 2.5%), b2
(L. plantarum 5%), and b3 (L. plantarum 7.5%). Parameters measured were the level of protein, pH value, and the total of lactic acid bacteria. Data obtained were then processed statistically using analysis of variance (ANOVA). If there is significant difference, then it will be continued by Duncan's Multiple Range Test. The result showed that the heating temperature did not give any effect on the level of protein of the fermented milk with different levels of starter Lactobacillus plantarum. However, the protein level of milk pasteurized was higher than the protein level of milk sterilized. Furthermore, the treatment significantly affected (P<0.05) on pH value at the range of 4.017 – 4.197 and it obtained that there was interaction between the two treatment factors. The multiple result also showed that the heating temperature significantly affected (P<0.01) the total of lactic acid bacteria, while the level of Lacttobacillus plantarum significantly affected (P<.0.05) the total of lactic acid bacteria. It can be concluded that the temperature and level of L. plantarum affected the pH and total lactic acid bacteria of fermented goat milk
The conservation activities and land use changes in the upstream Bedadung watershed
Authors: Petrina J M , Alfarisy F K , Andriyani I , Suciati L P 
Published: February 2021

Abstract

Bedadung watershed is one of the largest watersheds in Jember Regency. The Bedadung watershed in upstream area is generally hilly with steep slopes, so it is prone to landslides and potential to erosion. The upstream area is a protected forest that functions as a water catchment area, turning into plantation and production forest to become the target of logging and deforestation. Conservation activities in the upstream watershed area is essential in the management of water resources. Natural resource management activities in the upstream area significantly affect the success of efforts to provide water and control water resources downstream damage. This study aimed to identify conservation activities in the upstream Bedadung watershed and the impact of changes in upstream land use on environmental damage. The conservation activities in the Jompo, Antrokan, Rempangan, and Rembangan Sub-watersheds is coffe plantation, cover crop, forestry, terrace, restoration, bush, grassland. The highest increase in land change in the four sub-watersged was irrigated land / field, while the decrease was non-irrigated land. The results of comparisons between the 2001 RBI map with the 2015 Landsat Image show an 8% forest loss and 7% increase in irrigated fields.
Risk analysis of Jernang plant (Daemonorops draco) in Aceh Province
Authors: Moulana R , Nilda C , Yusriana  , Gunawan V 
Published: February 2021

Abstract
Jernang is a non-timber forest product (NTFP) which has started to be traded and become a high-value commodity. Jernang is a type of rattan that produces a resin known as “dragon's blood” which has many benefits such as dye raw materials in the ceramics, marble, wood, paper and pharmaceutical industries. Aceh province is one potential area for Jernang development. Supply chain is a complex system that has elements that are orderly, interrelated, dynamic, have specific goals and are probabilistic. In the Jernang supply chain there are risks that can cause losses and failures in production. Failure in production does not only occur at the end process but can also occur at the beginning or when the production process is being carried out. Through the Failure Modes and Effect Analysis (FMEA) method, it is expected that each form of failure can be identified in the production process. The results identified indicate that nineteen risk factors at the producer level. Based on the calculation of Risk Priority Number (RPN), the risk of decreasing production results is the most important risk. As such, this risk is the first priority that must be addressed.
Modification and performance improvement of chopper palm frond (AE03-Type)
Authors: Bulan R , Yunus Y , Mustaqimah  , Sitorus A 
Published: February 2021

Abstract
A chopper machine has been developed to chop oil palm frond (OPF) for cattle feed in Aceh province. This paper reports the results of the modification of the third generation chopper machine named AE03-type. The purpose of this study is to improve the performance of the chopper machine for OPF through the process of modifying the chopper blade. Modifications made are designing a chopper blade with a plate thickness of 6 mm, a length of 15.5 cm and a width of 4 cm arranged in a spiral around a solid shaft with a diameter of 1 inch with a length of 100 cm, as many as 36 pieces. The parameters measured to show the performance of the chopper machine are dimension average of chopped, the percentage of chopped OPF, chopping efficiency, and capacity of the machine. Three variations of rotation speed are tested on the engine, which is 800 rpm, 1200 rpm, and 1600 rpm, respectively. The results show that modifying the chopper knife can improve the performance of the chopper machine. The best rotation speed for this chopper machine is 1200 rpm with length and width of chopped, OPF percentage of chopped, chopping efficiency, and capacity of the machines are 27.5 mm, 1.5 mm, 86.45%, 98.37%, and 147.85 kg/h, respectively. The size of the chopped is following the dimensions of feed for cattle feed needs, especially those in Aceh Province.
Rapid assessment of climate change issues in Indonesia strategic environmental assessment (SEA)-KLHS
Authors: Umam A H 
Published: February 2021

Abstract
Strategic Environmental Assessment (SEA) or KLHS is becoming increasingly popular in Indonesia following the promulgation of government regulation No. 46 of 2016, concerning the procedures of its organization. The SEA, which was at first voluntary, is now mandatory before the integration into a regional spatial and a medium-term development plan. Therefore, this study aims to evaluate the extent to which climate change issues are addressed in the Strategic Environmental Assessment. Furthermore, several SEA documents that are very limited in Indonesia and only obtain on the internet were evaluated. The document consists of the Medium-Term Development Plan, Spatial Planning, and SEA in the mineral and energy sector. In addition, the study adopted a set of evaluation criteria used by Nadruz and Gallardo (2015) [1], which is a modification of the framework developed by Wende et al. (2012) [2]. The results showed that climate change issues in the SEA are still very diverse and not evenly distributed from various existing documents. Some SEA of the province medium-term development plan makes the issue very important while other documents do not. The SEA document of the mining sector contains 18 climate change criteria. Conversely, the spatial planning document contains 12-22 criteria, and the SEA for medium-term development plan contains 12-22 as well. From this study, it can be concluded that the issue of climate change still varies greatly in Indonesian SEA, and it is therefore not significant.
The quality assessment on fermented virgin coconut oil treated under microwave heating
Authors: Khathir R , Hartuti S , Fadillah N 
Published: February 2021

Abstract
The study aimed to evaluate the quality of fermented virgin coconut oil (FVCO) treated under microwave heating. The FVCO was produced by local farmer from Aceh Besar District, the province of Aceh, Indonesia. A home microwave oven Samsung ME731K at frequency of 2,450MHz was used to heat 100ml of FVCO for 10 minutes. The experimental was designed by the variation of microwave power at 4 levels i.e. 0, 300, 450, and 600W. The parameters assessed were temperature, moisture, free fatty acid (FFA), and peroxide value (PV). The data was analysed by using analysis of variance (ANOVA). Results showed that the quality of FVCO still could not be improved yet where most of parameters observed did not meet the quality standard of VCO. However, the challenge of using microwave heating to improve the FVCO quality is quite big since the treatment had significantly influenced the FVCO temperature. Further study is highly recommended to treat the FVCO under microwave heating with the improvement in the procedure of observation.
A mini review on characteristic of depik fish (Rasbora tawarensis) and its processed products
Authors: Rahmi F , Susanti Z , Nilda C , Muzaifa M 
Published: February 2021

AbstractDepikfish (Rasbora tawarensis) is a tpical endemic freshwater fish of Laut Tawar Lake in Central Aceh, Aceh Province. This lake has become the pride of the Gayo community as a source of clean water for various needs, a source of livelihood for residents and a tourist destination. Laut Tawar Lake anddepikfish have become the trademark of the city of Takengon, Central Aceh. However, it is unfortunate that due to several reasons such as environmental degradation, introduction of foreign fish, destructive fishing techniques, pollution and climate change globally,depikfish population is currently decreasing drastically. Evendepikfish has been appointed as a fish with a threatened status. Studies on the existence ofdepikfish as local food, form of presentation and nutrition are still rarely carried out. This article tries to review the existence ofdepikfish and its processed products through several existing studies including classification, distribution, morphological and genetic characteristics ofdepikfish as well as processing and characteristics of processed products.