bluuebunny/crossref_metadata_2025_split huggingface dataset:
RePhine: An Integrative Method for Identification of Drug Response-Related Transcriptional Regulators
Authors: Wang Xujun , Zhang Zhengtao , Qin Wenyi , Liu Shiyi , Liu Cong , Genchev Georgi Z. , Hui Lijian , Zhao Hongyu , Lu Hui 
Published: March 2021

Abstract
Transcriptional regulators (TRs) participate in essential processes in cancer pathogenesis and are critical therapeutic targets. Identification of drug response-related TRs from cell line-based compound screening data is often challenging due to low mRNA abundance of TRs, protein modifications, and other confounders (CFs). In this study, we developed a regression-based pharmacogenomic and ChIP-seq data integration method (RePhine) to infer the impact of TRs on drug response through integrative analyses of pharmacogenomic and ChIP-seq data. RePhine was evaluated in simulation and pharmacogenomic data and was applied to pan-cancer datasets with the goal of biological discovery. In simulation data with added noises or CFs and in pharmacogenomic data, RePhine demonstrated an improved performance in comparison with three commonly used methods (including Pearson correlation analysis, logistic regression model, and gene set enrichment analysis). Utilizing RePhine and Cancer Cell Line Encyclopedia data, we observed that RePhine-derived TR signatures could effectively cluster drugs with different mechanisms of action. RePhine predicted that loss-of-function of EZH2/PRC2 reduces cancer cell sensitivity toward the BRAF inhibitor PLX4720. Experimental validation confirmed that pharmacological EZH2 inhibition increases the resistance of cancer cells to PLX4720 treatment. Our results support that RePhine is a useful tool for inferring drug response-related TRs and for potential therapeutic applications. The source code for RePhine is freely available at https://github.com/coexps/RePhine.
The Hispanic Paradox in Non-Small Cell Lung Cancer
Authors: Kumar Rohit , Castillero Franklin , Bhandari Shruti , Malapati Sindhu , Kloecker Goetz 
Published: March 2021

Objective/Background:
According to the U.S. Census Bureau, 18% of the total population in the United States identified themselves as Hispanic in 2016 making it the largest minority group. This study aimed to evaluate the effect of Hispanic ethnicity on the overall survival of patients with non-small cell lung cancer (NSCLC) using a large national cancer database.

Methods:
We used the National Cancer Database to identify patients diagnosed with NSCLC between 2010 and 2015. The two comparative groups for this study were non-Hispanic Whites (NHWs) and Hispanics. The primary outcome was overall survival.

Results:
Of the 555,475 patients included in the study, 96.9% and 3.1% were NHWs and Hispanics with a median follow up of 12.6 months (interquartile range 4.1–30.6) and 12.1 months (interquartile range 3.8–29.5), respectively. Hispanics were more likely to be uninsured, and live in areas with lower median household income or education level. In the age-, sex-, and comorbidities-adjusted Cox model, the overall survival was significantly better in Hispanics compared with NHWs (hazard ratio [HR] 0.92, 95% confidence interval 0.90–0.93, p < .001). In a demographic, socioeconomic, clinical, and facility characteristics adjusted Cox model, Hispanics had further improvement in survival (HR 0.79, 95% confidence interval 0.78–0.81, p < .001). The survival advantage was seen in all cancer stages: Stage I–HR 0.76 (0.71–0.80), Stage II–HR 0.85 (0.79–0.92), Stage III–HR 0.81 (0.77–0.85), and Stage IV–HR 0.79 (0.77–0.81).

Conclusion:
Hispanic ethnicity was associated with better survival in NSCLC. This survival advantage is likely the result of complex interactions amongst several physical, social, cultural, genomic, and environmental factors.
Effects of forebody boundary layer on the performance of a submerged inlet
Authors: Xie W.Z. , Yang S.Z. , Zeng C. , Liao K. , Ding R.H. , Zhang L. , Guo S. 
Published: March 2021

ABSTRACTThe use of a submerged inlet is advantageous in modern aircrafts because of its low drag resistance, small radar cross section and ease of maintenance. Although it is well known that the forebody boundary layer deteriorates the aerodynamic performance of a submerged inlet, the level of impact has not yet been fully quantified. To quantify the forebody boundary-layer effect, a submerged diverter was designed to remove a portion of the low-energy boundary flow. The flow pattern and aerodynamic performance of a submerged inlet, with and without the diverter, were investigated by wind-tunnel experimentation and numerical simulations. The effects of mass flow, free stream speed, angle-of-attack and sideslip angle on the aerodynamic characteristics of the inlet with and without the submerged diverter were studied, over an operating envelope of M0 = 0.3 ∼ 0.6, $\alpha$ = –6$^{\circ}$ ∼ 8$^{\circ}$ and $\beta$ = 0$^{\circ}$ ∼ 4$^{\circ}$. The results indicate that both the total pressure loss and the circumferential distortion can be significantly reduced with the removal of the forebody boundary-layer low-energy flow. Meanwhile, the main mechanisms for losses in the submerged inlet were also analysed.
Mass Casualty Incident Management for Resource-Limited Settings: Lessons From Central Haiti
Authors: Rouhani Shada A. , Rimpel Linda , Plantin Jean Jimmy , Calahan Christopher F. , Julmisse Marc , Edmond Marie Cassandre , Checkett Keegan A. , Marsh Regan H. 
Published: March 2021

AbstractObjective:Mass casualty incidents (MCIs) have gained increasing attention in recent years due multiple high-profile events. MCI preparedness improves the outcomes of trauma victims, both in the hospital and prehospital settings. Yet most MCI protocols are designed for high-income countries, even though the burden of mass casualty incidents is greater in low-resource settings.Results:Hôpital Universitaire de Mirebalais (HUM), a 300-bed academic teaching hospital in central Haiti, developed MCI protocols in an iterative process after a large MCI in 2014. Frequent MCIs from road traffic collisions allowed protocol refinement over time. HUM’s protocols outline communication plans, triage, schematics for reorganization of the emergency department, clear delineation of human resources, patient identification systems, supply chain solutions, and security measures for MCIs. Given limited resources, protocol components are all low-cost or cost-neutral. Unique adaptations include the use of 1) social messaging for communication, 2) mass casualty carts for rapid deployment of supplies, and 3) stickers for patient identification, templated orders, and communication between providers.Conclusion:These low-cost solutions facilitate a systematic response to MCIs in a resource-limited environment and help providers focus on patient care. These interventions were well received by staff and are a potential model for other hospitals in similar settings.
Analysis of dietary patterns and nutritional adequacy in lactating women: a multicentre European cohort (ATLAS study)
Authors: Wang Dantong , Thielecke Frank , Fleith Mathilde , Afeiche Myriam C. , De Castro Carlos A. , Martínez-Costa Cecilia , Haaland Kirsti , Marchini Giovanna , Agosti Massimo , Domellöf Magnus , Costeira Maria Jose , Billeaud Claude , Vanapee Mireille , Picaud Jean-Charles , Samuel Tinu Mary 
Published: March 2021

Abstract
Eating habits of lactating women can influence the nutrient composition of human milk, which in turn influences nutrient intake of breastfed infants. The aim of the present study was to identify food patterns and nutritional adequacy among lactating women in Europe. Data from a multicentre European longitudinal cohort (ATLAS study) were analysed to identify dietary patterns using cluster analysis. Dietary information from 180 lactating women was obtained using 3-d food diaries over the first 4 months of lactation. Four dietary patterns were identified: ‘vege-oils’, ‘fish-poultry’, ‘confectionery-salads’ and ‘mixed dishes’. Nutrition adequacy was not significantly different between clusters, but the ‘vege-oils’ cluster tended to yield the highest nutrition adequacy measured by Mean Adequacy Ratio. Compared with European dietary reference values (DRVs) for lactating women, women in all clusters had inadequate intakes of energy, pantothenic acid, folate, vitamin C, vitamin A, vitamin D, zinc, iodine, potassium and linoleic acid. Adequate intake for fibre and α-linolenic acid was only achieved in the ‘vege-oils’ cluster. Overall, fat intake was above DRVs. The present study showed that various dietary patterns do not adequately supply all nutrients, indicating a need to promote overall healthy dietary habits for European lactating women.
Revolutions in the head: Darwin, Malthus and Robert M. Young
Authors: Secord James A. 
Published: March 2021

AbstractThe late 1960s witnessed a key conjunction between political activism and the history of science. Science, whether seen as a touchstone of rationality or of oppression, was fundamental to all sides in the era of the Vietnam War. This essay examines the historian Robert Maxwell Young's turn to Marxism and radical politics during this period, especially his widely cited account of the ‘common context’ of nineteenth-century biological and social theorizing, which demonstrated the centrality of Thomas Robert Malthus's writings on population for Charles Darwin's formulation of the theory of evolution by natural selection. From Young's perspective, this history was bound up with pressing contemporary issues: ideologies of class and race in neo-Darwinian evolutionary theory, the revival of Malthusian population control, and the role of science in military conflict. The aim was to provide a basis for political action – the ‘head revolution’ that would accompany radical social change. The radical force of Young's argument was blunted in subsequent decades by disciplinary developments within history of science, including the emergence of specialist Darwin studies, a focus on practice and the changing political associations of the history of ideas. Young's engaged standpoint, however, has remained influential even as historians moved from understanding science as ideology to science as work.
Effect of yoga and meditation on tinnitus: a systematic review
Authors: Gunjawate D R , Ravi R 
Published: March 2021

AbstractObjectiveThe present systematic review aimed to explore the published literature on the application of yoga and meditation for tinnitus.MethodA systematic search was carried out to identify the eligible studies exploring the effect of yoga and meditation on tinnitus in PubMed, Scopus and Cochrane Library electronic databases. Studies on the application of yoga and meditation on tinnitus were identified following a three-step screening process by both the authors independently. A mixed-methods appraisal tool was used to perform the quality appraisal of the included studies.ResultsFive studies were shortlisted and included in the present review. Four studies had used different types of yoga and pranayama, while one used relaxation therapy. Three studies concluded that there were positive effects of yoga on tinnitus, such as a reduction in severity, stress, anxiety and irritability associated with tinnitus and improved quality of life.ConclusionThis review highlights the application of yoga and meditation in management of tinnitus along with regular otological and audiological treatment options. Furthermore, there is a need to have more randomised controlled trials in this area to evidence the effect of yoga and meditation on tinnitus empirically.
Partitioning tree diversity patterns to prioritize conservation investments
Authors: McKenzie Patrick F , Iacona Gwenllian D , Larson Eric R , Armsworth Paul R 
Published: March 2021

SummaryThe available tools and approaches to inform conservation decisions commonly assume detailed distribution data. We examine how well-established ecological concepts about patterns in local richness and community turnover can help overcome data limitations when planning future protected areas. To inform our analyses, we surveyed tree species in protected areas in the southern Appalachian Mountains in the eastern USA. We used the survey data to construct predictive models for alpha and beta diversity based on readily observed biophysical variables and combined them to create a heuristic that could predict among-site richness in trees (gamma diversity). The predictive models suggest that site elevation and latitude in this montane system explain much of the variation in alpha and beta diversity in tree species. We tested how well resulting protected areas would represent species if a conservation planner lacking detailed species inventories for candidate sites were to rely only on our alpha, beta and gamma diversity predictions. Our approach selected sites that, when aggregated, covered a large proportion of the overall species pool. The combined gamma diversity models performed even better when we also accounted for the cost of protecting sites. Our results demonstrate that classic community biogeography concepts remain highly relevant to conservation practice today.
The Role of Synthetic A Priori Propositions in the Development of Kant’s Account of Practical Autonomy: A Critique of Watkins’ Reading of Kant’s Prolegomena
Authors: Pollok Konstantin 
Published: March 2021

AbstractI draw attention to a 12-page Vorarbeit to Kant’s Prolegomena from the so-called Scheffner-Nachlaß and argue that the parallel Kant draws there between the possibility of theoretical and practical synthetic a priori propositions provides important insight into the development of his account of practical autonomy in the Groundwork. Based on a brief sketch of the role synthetic a priori propositions play in the development of Kant’s critical philosophy, I conclude that for Kant the objective validity of any science depends on the objective validity of a number of synthetic a priori propositions.
Oliver Williamson: a Hero's journey on the merits
Authors: Mahoney Joseph T. , Nickerson Jackson 
Published: March 2021

AbstractJoseph Campbell describes a narrative pattern for a hero's journey. ‘A hero ventures forth from the world of common day into a region of supernatural wonder: fabulous forces are there encountered and a decisive victory is won: the hero comes back from the mysterious adventure with the power to bestow boons on his fellow man’ (2008: 30). This paper looks at Oliver E. Williamson's life through Campbell's lens and reveals his journey, challenges, and triumphs not only for himself but also for all students of the science of organization.
Optimization of spaceflight millimeter-wave impedance matching networks using laser trimming
Authors: Parow-Souchon K. , Cuadrado-Calle D. , Rea S. , Henry M. , Merritt M. , Hunyor P. , Brewster N. , Harman L. , Spindloe C. , Sykes P. , Huggard P. G. , Moyna B. , Ellison B. 
Published: March 2021

AbstractRealizing packaged state-of-the-art performance of monolithic microwave integrated circuits (MMICs) operating at millimeter wavelengths presents significant challenges in terms of electrical interface circuitry and physical construction. For instance, even with the aid of modern electromagnetic simulation tools, modeling the interaction between the MMIC and its package embedding circuit can lack the necessary precision to achieve optimum device performance. Physical implementation also introduces inaccuracies and requires iterative interface component substitution that can produce variable results, is invasive and risks damaging the MMIC. This paper describes a novel method for in situ optimization of packaged millimeter-wave devices using a pulsed ultraviolet laser to remove pre-selected areas of interface circuit metallization. The method was successfully demonstrated through the optimization of a 183 GHz low noise amplifier destined for use on the MetOp-SG meteorological satellite series. An improvement in amplifier output return loss from an average of 12.9 dB to 22.7 dB was achieved across an operational frequency range of 175–191 GHz and the improved circuit reproduced. We believe that our in situ tuning technique can be applied more widely to planar millimeter-wave interface circuits that are critical in achieving optimum device performance.
Cardiovascular risk factors in extended family members and birthweight in offspring
Authors: Shaikh Fareeha , Kjollesdal Marte K. , Carslake David , Thoresen Magne , Næss Øyvind 
Published: March 2021

AbstractLow birthweight has been related to an increased risk of adult cardiovascular disease (CVD). Transgenerational studies have been used to investigate likely mechanisms underlying this inverse association. However, previous studies mostly examined the association of offspring birthweight with CVD risk factors among parents. In this study, we investigated the association between offspring birthweight and individual CVD risk factors, an index of CVD risk factors, and education in their parents, aunts/uncles, and aunts’/uncles’ partners. Birth data (Medical Birth Registry, Norway (MBRN) (1967–2012)) was linked to CVD risk factor data (the County Study, Age 40 Program, and Cohort Norway (CONOR)) for the parents, aunts/uncles, and their partners. For body mass index (BMI), resting heart rate (RHR), systolic blood pressure (SBP), total cholesterol (TC), triglycerides (TG), and a risk factor index, the associations were examined by linear regression. For smoking and education, they were examined by logistic regression. Low birthweight was associated with an unfavorable risk factor profile in all familial relationships. For each kg increase in birthweight, the mean risk factor index decreased by −0.14 units (−0.15, −0.13) in mothers, −0.11 (−0.12, −0.10) in fathers, and −0.02 (−0.05, −0.00) to −0.07 (−0.09, −0.06) in aunts/uncles and their partners. The association in mothers was stronger than fathers, but it was also stronger in aunts/uncles than their partners. Profound associations between birthweight and CVD risk factors in extended family members were observed that go beyond the expected genetic similarities in pedigrees, suggesting that mechanisms like environmental factors, assortative mating, and genetic nurturing may explain these associations.
Assessment of Temperature Changes on the Tibetan Plateau During 1980–2018
Authors: Peng Xiaoqing , Frauenfeld Oliver W. , Jin Haodong , Du Ran , Qiao Lina , Zhao Yaohua , Mu Cuicui , Zhang Tingjun 
Published: March 2021

AbstractSurface air temperatures affect a diverse set of physical and biological systems in many parts of the world. For regional‐scale studies, gridded surface air temperature data sets are frequently used as input variables. Here we evaluate 10 commonly used gridded air temperature products with spatial resolutions ranging from 0.1° × 0.1° to 5.0° × 5.0°, relative to observations from in situ weather stations on the Tibetan Plateau. Gridded temperatures are consistently lower, with mean annual air temperature biases ranging from −4.68 °C to −1.72 °C, and root mean square error (RMSE) from 3.24 °C to 6.11 °C. The mean biases of mean seasonal air temperatures for spring, summer, autumn, and winter are −3.21 °C, −2.98 °C, −2.89 °C, and −2.98 °C, respectively, and RMSEs of 4.81 °C, 4.39 °C, 4.3 °C, and 4.7 °C. Of all 10 products, the China meteorological forcing data set compares best with observations. Annual and season temperatures all increase significantly during 1980–2018 on the Tibetan Plateau, with winter dominating the warming rate.
Using Array‐Derived Rotational Motion to Obtain Local Wave Propagation Properties From Earthquakes Induced by the 2018 Geothermal Stimulation in Finland
Authors: Taylor G. , Hillers G. , Vuorinen T. A. T. 
Published: March 2021

AbstractWe estimate vertical rotation rates for 204 earthquakes that were induced by the 2018 stimulation of the Espoo/Helsinki geothermal reservoir from wavefield gradients across geophone arrays. The array‐derived rotation rates from seismograms recorded at 6–9 km hypocentral distances vary between 10−9 and 10−7 rad s−1, indicating a comparable sensitivity to portable rotational instruments. Using co‐located observations of translational and rotational motion, we estimate the local propagation direction and the apparent phase speed of SH waves, and compare these estimates with those obtained by S wave beamforming. Propagation directions generally align with the earthquake back azimuths, but both techniques show deviations indicative of heterogeneous seismic structure. The rotational method facilitates a station‐by‐station approach that resolves site specific variations that are controlled by the local geology. We measure apparent S wave speeds larger than 5 km s−1, consistent with steep incidence angles and high propagation velocities in the Fennoscandian Shield.
Projected Changes to Australian Marine Heatwaves
Authors: Misra R. , Sérazin G. , Meissner K. J. , Sen Gupta A. 
Published: March 2021

AbstractMarine heatwaves are extreme oceanic events that can have severe impacts on ecosystems and economies. Recent studies have suggested future increases in the severity and duration of these events. However, these findings are based on coarse resolution climate models that cannot resolve important ocean structures. This study uses a 0.25° coupled regional model to quantify how marine heatwaves around Australia respond under a high emissions scenario. We find that increases to future marine heatwave statistics are primarily caused by changes in the mean temperature, with changes in variability important in some areas. Temperature variance changes are most prominent close to Tasmania, with a covariance temperature budget demonstrating that this is linked to large simulated increases in East Australian Current transport and variability. Close to New Zealand, changes in surface heat fluxes also play an important role. These results quantify the response of marine heatwave characteristics to future temperature changes.
Venus' Mass Spectra Show Signs of Disequilibria in the Middle Clouds
Authors: Mogul Rakesh , Limaye Sanjay S. , Way M. J. , Cordova Jaime A. 
Published: March 2021

AbstractWe present a re‐examination of mass spectral data obtained from the Pioneer Venus Large Probe Neutral Mass Spectrometer. Our interpretations of differing trace chemical species are suggestive of redox disequilibria in Venus' middle clouds. Assignments to the data (at 51.3 km) include phosphine, hydrogen sulfide, nitrous acid, nitric acid, carbon monoxide, hydrochloric acid, hydrogen cyanide, ethane, and potentially ammonia, chlorous acid, and several tentative PxOy species. All parent ions were predicated upon assignment of corresponding fragmentation products, isotopologues, and atomic species. The data reveal parent ions at varying oxidation states, implying the presence of reducing power in the clouds, and illuminating the potential for chemistries yet to be discovered. When considering the hypothetical habitability of Venus' clouds, the assignments reveal a potential signature of anaerobic phosphorus metabolism (phosphine), an electron donor for anoxygenic photosynthesis (nitrite), and major constituents of the nitrogen cycle (nitrate, nitrite, ammonia, and N2).