bluuebunny/crossref_metadata_2025_split huggingface dataset:
Royal Far West's Allied Health Telehealth Services for Children Post‐Bushfires
Authors: Curtin Michael , Iellamo Tayla , Anderson Donnah , Rassafiani Mehdi , Parnell Tracey , Eagland Sarah , Whitsed Rachel 
Published: December 2024

ABSTRACTObjectiveTo evaluate the effectiveness of Royal Far West allied health telehealth services to support the health and well‐being of children affected by the bushfires.SettingIn response to the 2019/2020 Black Summer bushfires, Royal Far West (RFW) implemented the Community Recovery Services (CRS) targeting the health and well‐being of affected children. One component of the CRS was the delivery of allied health telehealth services to children.ParticipantsOne hundred and thirty‐five children participated in occupational therapy, psychology and/or speech pathology telehealth. Forty‐eight parents/carers completed a telehealth satisfaction survey.DesignMeasures used to determine effectiveness included child and parent/carer satisfaction surveys, the Canadian Occupational Performance Measure (COPM), the Goal Attainment Scale (GAS) and the Strengths and Difficulties Questionnaire (SDQ).ResultsThe children overwhelmingly stated that they felt listened to (89%), enjoyed telehealth sessions (84%) and learned new ways to cope with their feelings (87%). Parents/carers reported that children had developed effective emotional regulation and coping strategies. COPM outcomes indicated the children demonstrated statistically significant large improvements in their self‐perceived performance of and satisfaction with their identified goals, p < 0.001. The GAS outcomes indicated that 86% of children attained or exceeded their set goals. A statistically significant improvement in children's mental health outcomes post‐telehealth was found, as measured by the SDQ (p < 0.05).ConclusionOccupational therapy, psychology and speech pathology telehealth sessions contributed to positive health and well‐being outcomes for children affected by the bushfires. The findings support the implementation of RFW's five key principles for telehealth services: (1) Access to a multidisciplinary team; (2) Practical resources; (3) Flexible delivery; (4) Providing in‐person session to support telehealth and (5) Take a ‘whole of child’ approach. Innovative telehealth offered children in geographically remote areas access to effective allied health support post‐disaster that was not readily available in their local communities.
Using protection motivation theory to explain Australian's motivations to engage in individual and collective climate actions
Authors: Mackay Matthew I. , Klas Anna , Fernando Julian , Kothe Emily J. , Ling Mathew 
Published: December 2024

AbstractUsing an Australian sample, the current study investigated the usefulness of protection motivation theory (PMT) in predicting intentions for two climate actions—one individual action (limiting household heating and/or cooling) and one collective action (writing a letter to a local Member of Parliament urging them to take action to mitigate climate change). The data were analysed in two ways: (1) regression analysis, to examine the independent effects of coping and threat appraisals, and (2) latent profile analysis (LPA), to understand how the coping and threat appraisals may act in combination. The regression showed that PMT explained a significant amount of variance for both behavioural intentions. While perceived response efficacy and self‐efficacy were significant unique predictors of both behavioural intentions, perceived response costs were a significant unique predictor of heating and/or cooling intentions. Although the regression analysis suggests that people were more motivated by coping appraisals for both outcomes, the LPA indicates that the coping appraisals are unlikely to lead to stronger intentions unless individuals perceive climate change to be sufficiently threatening. PMT research could benefit from employing LPA to identify participant profiles with heightened likelihoods of reporting stronger intentions to participate in climate actions.
Reflections on unheroic fieldwork
Authors: Marten Meredith G. 
Published: December 2024

AbstractMore than a decade ago, at the beginning of my doctoral fieldwork, I was kidnapped and robbed one morning in Dar es Salaam, Tanzania. As I negotiated the logistical and emotional aftermath of this traumatic event, I took refuge in elite, privileged spaces. In doing so, I grappled with difficult problems: my privilege, my fear and feelings of vulnerability, and my broader moral concerns about Tanzania's poverty, gross wealth inequities, and the impacts these have on public health. Here, using Harrison's framing of multiple consciousness, I reflect on my vulnerability and privilege, and how they illuminate the impact the kidnapping had on my research and my perspectives on knowledge production. I call for our discipline to continue dismantling narratives of heroic fieldwork and to make more compassionate space for honest stories of our mistakes and privileges. Doing so would allow anthropologists to more faithfully account for fieldwork's messy unpredictabilities and tangled relations.
Sacralising Chinese Entrepreneurship: Christianity and Chinese Entrepreneurial Migration in the Making of a Patriarchal Diaspora
Authors: Cao Nanlai 
Published: December 2024

ABSTRACTThis article explores China's global economic presence by focusing on the changing dynamics of diasporic Chinese entrepreneurship in France. Since the turn of the new century, the ethnic Chinese population in France has become increasingly heterogeneous in migratory trajectory and socioeconomic profile. Accordingly, the focus on economic activities among tight‐knit groups in the traditional model of an ethnic enclave economy might not be adequate to capture new developments in Chinese entrepreneurship that also involve transnational religious practises. Drawing on a multi‐year ethnographic study of the Chinese Christian community in Paris—a major business centre of Chinese wholesale products in Europe, this article explores the Chinese congregational life in one of the most secularised areas of Europe in order to provide an alternative explanation for the relationship of religion and Chinese entrepreneurship. It shows that the main stakeholders spearheading diasporic church growth are those first‐generation male Chinese family entrepreneurs who place paramount emphasis on maintaining ethnic cultural roots and a traditional patriarchal social order. The image of Chinese Christian entrepreneurs with both intense economic aspirations and religious zeal navigating daily life in diaspora provides a timely counterpoint to the popular view of global Chinese migrants as purely economic agents.
“You don't need money to give alms”: The protective capacity of faith and spiritual kinship among domestic workers in Zanzibar
Authors: Ott Jessica 
Published: December 2024

AbstractFew domestic workers on the semiautonomous Tanzanian archipelago of Zanzibar are registered union members, and most domestic workers neither receive nor demand their legal right to a formal contract. Relying on my yearlong engagement between 2017 and 2018 with a women's Islamic studies group and a life history interview with a domestic worker, this essay explores domestic workers' reliance on alternative protective mechanisms from unionization and formalization. The domestic workers I engaged with cultivated relationships with God, negotiated dignity, received affirmation of their spiritual equality, and developed spiritual kinship connections in faith‐based spaces. They also sought to ensure their physical and social well‐being through kin‐based connections and recruitment mechanisms. Kin‐based connections that were spiritual or that connected domestic workers to employers were more protective than kinship relations cultivated in the context of work. Furthermore, domestic workers transformed routine work tasks into opportunities to practice devotion, which reflects Swahili/Islamic understandings of personhood as going beyond the category of worker. Religious spaces and spiritual kinship offer protection to domestic workers through the forms of reciprocity they enable and are thus often a more viable framework than unionization and formalization for overcoming the compounding effects of economic crisis and social inequality on domestic workers' lives.
Roundtable discussion: Domestic worker organizing in Latin America and beyond
Authors: Baiocchi María Lis , Coe Cati , Fleischer Friederike , Hunter‐Pazzara Brandon , de Casanova Erynn Masi , Valles Dario 
Published: December 2024

AbstractIn 2011, the International Labor Organization (ILO) adopted the Domestic Worker Convention (no. 189), which established labor standards for household workers, including protection from abuse, provisions to ensure freedom of movement for migrant domestic workers, coverage under national minimum wage, overtime, child labor, and human rights laws, and access to contact information of private employers and appropriate legal resources, among others. Domestic worker advocates throughout Latin America rallied behind the ILO's Domestic Worker Convention to ensure its ratification at the national level. Latin American and Caribbean nations account for 55% of the national signatories to the convention; at the same time, 77% of domestic workers in the region remain informally employed. The roundtable discussion brought together scholars conducting research in Argentina, Colombia, Ecuador, and Mexico, and among Central Americans in the United States, to address the impact of the ILO convention and to share their research on domestic work and domestic worker movements. How have the changes in domestic work regulation affected the organizing efforts of domestic workers? How are domestic workers advocating for their rights in the wake of the ILO Convention?
Exploring the ecological relationship between temperature and prosocial behaviour: A geographical and temporal analysis
Authors: Ng Henry Kin Shing 
Published: December 2024

AbstractPrevious research on the link between temperature and prosociality has produced mixed findings. A recent meta‐analysis focusing on laboratory‐based research concluded that the effect was null, a conclusion that was subject to low ecological validity. This paper complements the discussion by investigating the link between ambient temperature and three indicators of real‐life prosociality in 164 regions over 14 years. The between‐regional comparison probes the relationship over a wide range of thermal conditions, whereas the within‐regional temporal comparison draws this literature to the real‐life problem of global warming. Bayesian analysis indicates that temperature is linked to helping strangers, but not volunteerism or charity donation. Hotter regions have more helping respondents than colder regions, and as a region warms, it also records more helping respondents. The positive link between temperature and helping is in line with social thermoregulation theory, but it is also subject to alternative explanations from a cultural perspective and sociological perspective. We conclude that it is unrealistic to expect temperature to have the same effect on all prosocial acts without considering contextual factors and the underlying mechanisms. Our findings call for a nuanced view concerning the effect of temperature on prosociality, which awaits verification by rigorous research designs.
Wildlife trade investigations benefit from multivariate stable isotope analyses
Authors: Prigge Tracey‐Leigh , Andersson Astrid A. , Hatten Chloe E. R. , Leung Even Y. M. , Baker David M. , Bonebrake Timothy C. , Dingle Caroline 
Published: December 2024

ABSTRACTThe investigation of wildlife trade and crime has benefitted from advances in technology and scientific development in a variety of fields. Stable isotope analysis (SIA) represents one rapidly developing approach that has considerable potential to contribute to wildlife trade investigation, especially in complementing other methods including morphological, genetic, and elemental approaches. Here, we review recent progress in the application of SIA in wildlife trade research to highlight strengths, shortcomings, and areas for development in the future. SIA has shown success in species identification, determination of geographic provenance, and differentiating between captive‐bred and wild individuals. There are also emerging applications of SIA in wildlife trade research including the use of labelling for traceability, more in‐depth analyses such as compound specific isotope analysis (CSIA), the use of trace metal isotopes, and monitoring the health of individuals (e.g. dietary history and nutritional status). While these applications have shown the utility of SIA in wildlife trade investigations, there are a number of limitations and issues where standardisation of analytical procedures would improve the comparability and interpretation of results. First, there is high variation within many stable isotopes geographically and within tissues – this variation presents opportunities for tracking and monitoring but can also challenge detection of patterns when variation is high. Second, the choice of isotopes and tissues within an organism (and ideally, multiple isotopes and tissues) should be considered carefully as different isotopes and tissue types have variable strengths and weaknesses depending on the research question. Third, validation of SIA methods remains underutilised in the field but is critical for applying SIA broadly to wildlife trade investigations and, particularly, for applications in forensics and in court. Fourth, standards are essential for comparisons across studies. Fifth, while some reference databases exist for the use of SIA in wildlife trade research (e.g. ivory), there are still few comprehensive reference databases available. Development of robust reference databases should be a priority for advancing the use of SIA in wildlife trade research, and ecological study more broadly. Ultimately, further recognition of these primary challenges (and development of solutions) within wildlife SIA research will improve the potential for this technique in tackling the threat of overexploitation to global biodiversity – particularly in concert with the application of other investigative techniques such as genetics and elemental analysis.
Mechanisms of Resistance to KRAS Inhibitors: Cancer Cells' Strategic Use of Normal Cellular Mechanisms to Adapt
Authors: Tanaka Noritaka , Ebi Hiromichi 
Published: December 2024

ABSTRACTKRAS was long deemed undruggable until the discovery of the switch‐II pocket facilitated the development of specific KRAS inhibitors. Despite their introduction into clinical practice, resistance mechanisms can limit their effectiveness. Initially, tumors rely on mutant KRAS, but as they progress, they may shift to alternative pathways, resulting in intrinsic resistance. This resistance can stem from mechanisms like epithelial‐to‐mesenchymal transition (EMT), YAP activation, or KEAP1 mutations. KRAS inhibition often triggers cellular rewiring to counteract therapeutic pressure. For instance, feedback reactivation of signaling pathways such as MAPK, mediated by receptor tyrosine kinases, supports tumor cell survival. Inhibiting KRAS disrupts protein homeostasis, but reactivation of MAPK or AKT can restore it, aiding tumor cell survival. KRAS inhibition also causes metabolic reprogramming and protein re‐localization. The re‐localization of E‐cadherin and Scribble from the membrane to the cytosol causes YAP to translocate to the nucleus, where it drives MRAS transcription, leading to MAPK reactivation. Emerging evidence indicates that changes in cell identity, such as mucinous differentiation, shifts from alveolar type 2 to type 1 cells, or lineage switching from adenocarcinoma to squamous cell carcinoma, also contribute to resistance. In addition to these nongenetic mechanisms, secondary mutations in KRAS or alterations in upstream/downstream signaling proteins can cause acquired resistance. Secondary mutations in the switch‐II pocket disrupt drug binding, and known oncogenic mutations affect drug efficacy. Overcoming these resistance mechanisms involves enhancing the efficacy of drugs targeting mutant KRAS, developing broad‐spectrum inhibitors, combining therapies targeting multiple pathways, and integrating immune checkpoint inhibitors.
Risk factors for isolated congenital heart defects in infants from Western Mexico
Authors: Cruz‐Cruz Jessica Paola , Nieto‐García Rafael , Rivera‐Ramírez Pascuala Berenice , Peña‐Padilla Christian , Bobadilla‐Morales Lucina , Corona‐Rivera Alfredo , Rodríguez‐Machuca Víctor Ulises , Valdez‐Muñoz Sandra Rocio , Corona‐Rivera Jorge Román 
Published: December 2024

AbstractCongenital heart defects (CHDs) are caused by a complex interaction between numerous genetic and environmental risk factors, some of which may differ between different populations. A case–control study was conducted among 1232 newborns, including 308 patients with isolated CHDs (cases) and 924 infants without birth defects (controls), born all during the period 2009–2023 at the Hospital Civil de Guadalajara “Dr. Juan I. Menchaca” (Guadalajara, Mexico). Potential parental risk factors for CHDs were compared using multivariate logistic regression analysis to evaluate the deviance explained by different variables of interest. Consanguinity [adjusted odds ratio (aOR) = 3.3; 95% confidence interval (CI) 1.3–8.5], relatives with CHD (aOR = 8.5; 95% CI 5.3–13.8), maternal first‐trimester exposure to diabetes (aOR = 3.5; 95% CI 2.4–5.1), hypertension (aOR = 2.6; 95% CI 1.5–4.4), alcohol consumption (aOR = 1.5; 95% CI 1.0–2.1), and illicit drug use (aOR = 2.4; 95% CI 1.2–5.3), as well as for the paternal history of alcohol consumption (aOR = 1.4; 95% CI 1.0–1.8) and illicit drug use (aOR = 2.7; 95% CI 1.7–4.1), were associated with CHDs. Contrarily, aOR for maternal age ≤19 years (aOR = 0.6; 95% CI 0.4–0.8) and maternal first‐trimester coffee consumption (aOR = 0.7; 95% CI 0.5–0.9) have protective odds. Our results suggest that genetic factors, maternal diseases, environmental exposures, and reproductive factors can increase the occurrence of isolated CHDs in our sample, and they are discussed as clues in its pathogenesis.
Identification of the Third Patient With PAICS Deficiency Harbouring the p.(Lys53Arg) Recurrent Variant, Extending the Phenotype Diversity
Authors: Boussion Simon , Aumar Madeleine , Hutt Antoine , Fron Damien , Fayoux Pierre , Ghoumid Jamal , Gottrand Frédéric , Smol Thomas 
Published: December 2024

ABSTRACTPhosphoribosylaminoimidazole carboxylase (PAICS) deficiency, caused by biallelic variants in PAICS gene, is an inborn error of de novo purine synthesis. Only two patients from a consanguineous family have been reported, with multiple congenital malformations, resulting in early neonatal death. Molecular analysis identified a homozygous p.(Lys53Arg) missense variant. We report the third case of PAICS deficiency in a 7 years old boy, presenting with polymalformative syndrome, but normal neurodevelopment. We report malformations not previously described in PAICS deficiency, notably congenital cardiopathy, and support the consistency of skeletal and oesophageal defects. Genome Sequencing identified the homozygous pathogenic variant p.(Lys53Arg), suggesting a recurrent variant in PAICS. A probable recurrence of PAICS deficiency occurred in a sibling, with a similar polymalformative syndrome antenatally diagnosed, but could not be confirmed molecularly. We further delineate the phenotype of PAICS deficiency and provide new insights concerning prognosis, notably in terms of neurodevelopment.
Next Generation Phenotyping and Synthetic Faces in Coffin Siris Syndrome
Authors: Hennocq Quentin , Lienhard Olivier , Rao Dipesh , Amiel Jeanne , Benichou Ludovic , Bongibault Thomas , Hidalgo Ana‐Julia Bravo , Cormier‐Daire Valérie , Lyonnet Stanislas , Picard Arnaud , Rio Marlène , Zaiter Ahmed , Garcelon Nicolas , Tkemaladze Tinatin , Khonsari Roman H. 
Published: December 2024

ABSTRACTDiagnostic wandering and delayed management are major issues in rare diseases. Here, we report a new Next‐Generation Phenotyping (NGP) model for diagnosing Coffin Siris syndrome (CSS) on clinical photographs among controls and distinguish the different genotypes. This retrospective and prospective study, conducted from 1998 to 2023, included frontal and lateral pictures of confirmed CSS. After automatic placement of landmarks, geometric features extraction using procrustes superimposition, and textural features using a gray‐level co‐occurrence matrix (GLCM), we incorporated age, gender, and ethnicity and used XGboost (eXtreme Gradient Boosting) for classification. An independent validation set of confirmed CSS cases from centers in Bangalore (India) and Tbilissi (Georgia) was used. We then tested for differences between genotype groups. Finally, we introduced a new approach for generating synthetic faces of children with CSS. The training set included over 196 photographs from our center, corresponding to 58 patients (29 controls, 29 CSS). We distinguished CSS from controls in the independent validation group with an accuracy of 90.0% (73.5%–97.9%, p = 0.001). We found no facial shape difference between the different genotypes.
Guidelines for Diagnosis of Noise‐Induced Hearing Loss and Their Specificity
Authors: Lutman Mark E. , de Carpentier John , Green Kevin 
Published: December 2024

ABSTRACTObjectivesA recent paper by Moore, Lowe and Cox has proposed guidelines for diagnosing noise‐induced hearing loss (NIHL). It is referred to here as the MLC guidelines. Our aim was to assess the specificity of those guidelines (i.e., freedom from false‐positive outcomes) and compare with pre‐existing guidelines.DesignWe applied the MLC guidelines and pre‐existing guidelines to three data sets composed of adults who do not have a history of material noise exposure and therefore cannot have NIHL.SettingNational Health Service (NHS) ENT clinic.ParticipantsFive hundred thirty‐six patients with hearing difficulty and/or tinnitus who denied material noise exposure. Two large archival population studies of hearing were also assessed, which included 3250 participants without material noise exposure.Main Outcome MeasureFalse‐positive outcome from guidelines.ResultsThe MLC guidelines demonstrated moderate or high false‐positive rates overall, the magnitude depending on the noise exposure scenario and whether clinical or population samples were considered. For the procedure applicable to steady broadband noise exposure, the false‐positive rate averaged 56% in the population samples, compared to 31% for previous guidelines. For exposure to intense impulse sounds, the MLC guidelines take a different approach and the false‐positive rate was about 70% in the population samples and even higher in the clinic sample. For exposure to intense tones, the MLC guidelines take yet another approach and the false‐positive rate reached 80%.ConclusionsThe MLC guidelines demonstrate poorer specificity than previous guidelines. Medical experts should be aware of their poor specificity and consequential likelihood of false‐positive diagnoses of NIHL.