bluuebunny/crossref_metadata_2025_split huggingface dataset:
PKM KADER DALAM ANALISIS DATA DAN PENGAMBILAN KEPUTUSAN BERBASIS ANDROID DI POSYANDU BALITA RW 9 KELURAHAN GONDORIYO NGALIYAN KOTA SEMARANG
Authors: Harsono Harsono , Sugiharto Sigit , Rinayati Rinayati 
Published: August 2021

Abstrack Pelaksanaan kegiatan PKM ini menitikberatkan dan berfokus pada upaya pendampingan terhadap kader posyandu dalam melakukan analisis dan pengambilan keputusan data pelaporan posyandu balita yang bermuara pada peningkatan pelayanan posyandu balita dilingkungan RW 9 Kelurahan Gondoriyo Ngaliyan SemarangTujuan dari pelaksanaan Pengabdian Kepada Masyarakat (PKM) ini adalah pendampingan dan pembuatan aplikasi berbasis android yang memudahkan kader dalam melakukan analisis data dan pengambilan keputusan terkait dengan data posyandu balita di RW IX Kelurahan Gondoriyo Ngaliyan SemarangMetode dalam pelaksanaan kegiatan PKM ini kegiatan yang dilakukan meliputi perijinan dari wilayah setempat, pengumpulan data, perancangan dan pembuatan aplikasi, uji coba aplikasi, Focus Group Discussion (FGD) peran kader posyandu balita, pelatihan dan simulasi aplikasi posyandu berbasis androidHasil dari evaluasi pelaksanaan PKM ini terlihat adanya peningkatan pengetahuan dan kemampuan kader dalam melakukan analisis dan pengambilan keputusan data posyandu balita melalui aplikasi android sehingga yang harapanya dapat meningkatkan pelayanan posyandu balita Kata Kunci: Analisis, Pengambilan Keputusan, Kader Posyandu Balita Abstrack The implementation of this PKM activity focues and focues on providing assistance to posyandu cadres in analyzing and making data decision on posyandu reporting for toddlers which leads to improving posyandu services for toddlers in RW 9 Gondoriyo Ngaliyan Semarang The purpose of the implementation of Community Service (PKM) is assistance and development of android-based application that make it easier for cadres to analyze data and make decisions related to data on posyandu under five at RW IX Gondoriyo Ngaliyan Semarang The method of implementing this PKM activity includes licensing from the local area, data collection, designing and making applications, application trials, focus group discussion (FGD) of the role of posyandu cadres for toddlers, training and simulation of Android-based posyandu applicationThe results of the evaluation of the implementation of this PKM show an increase in the knowledge and ability of cadres in analyzing and making decisions on posyandu toddler data through an android application so that the hope can improve posyandu services for toddlers Keyword : Analysis, Decision Making, Posyandu Toddler Cadres
Pembentukan dan Pendampingan Kader Kesehatan Warga RT 08/III Kelurahan Ngijo, Kecamatan Gunung Pati, Kota Semarang (Sadar Kedokteran Nuklir)
Authors: Rahmat Basuki 
Published: August 2021

Aplikasi radiasi di berbagai bidang di Indonesia telah cukup meluas. Berdasar data Badan Pengawas Tenaga Nuklir (BAPETEN) yang ditampilkan pada situsnya, sampai awal April 2015 telah diterbitkan sebanyak 12.189 izin pemanfaatan tenaga nuklir untuk 2.894 instansi di seluruh Indonesia. Dari seluruh izin dan instansi tersebut sebanyak 6.196 izin atau sekitar 50,8 % dan 2.061 instansi atau sekitar 71,2% merupakan izin dan instansi pemanfaatan di bidang medis. Data ini menggambarkan bahwa bidang medis merupakan bidang pemanfaatan nuklir yang terbesar di Indonesia. Selain membawa manfaat yang sangat besar, pemanfaatan tenaga nuklir diketahui pula memiliki efek yang berbahaya bagi kesehatan manusia. Efek dari radiasi dapat berupa deterministik atau stokastik. Efek determinstik, yang saat ini sebutannya diganti menjadi efek radiasi jaringan, merupakan efek yang dapat terjadi pada suatu organ atau jaringan tubuh tertentu yang menerima radiasi dengan dosis tinggi, sementara efek stokastik merupakan efek akibat penerimaan radiasi dosis rendah di seluruh tubuh yang baru diderita oleh orang yang menerima dosis setelah selang waktu tertentu, atau oleh turunannya. Dengan adanya kedua jenis efek yang berbahaya tersebut maka setiap aplikasi radiasi di Indonesia harus diatur dan diawasi secara ketat secara internal oleh bagian keselamatan dan kesehatan kerja dari instansi atau perusahaan yang memanfaatkan radiasi tersebut, dan secara eksternal oleh BAPETEN yang diberi tanggung jawab untuk melaksanakan pengawasan tersebut. Kata Kunci : radiasi, kedokteran nuklir, efek stokastik, dosis radiasi
Sensitivity Study of the Influence of Blade Sectional Stiffness Parameters on the Aeroelastic Response of Wind Turbines
Authors: Chen Cheng , Wang Tongguang , Wang Long 
Published: August 2021

With the development of wind turbines as a result of large-scale and offshore trends, the wind turbine size is becoming increasingly larger. The passive control technique is used to alleviate the increasing loads on the blade for the sake of improving the durability of the wind turbine. The ply design of shells considering the coupling effect of bending and torsion is one of the passive control techniques. The bending torsion coupling stiffness is one of the parameters of the blade section stiffness matrix. In order to fully understand the influence of each blade stiffness parameter on the aeroelastic responses of wind turbines and to consider the influence of structural characteristics on the aeroelastic responses in blade design, the influences and sensitivity of each stiffness parameter in the 6 × 6 stiffness matrix of the blade sections on the aeroelastic responses of the wind turbines are systematically studied under steady wind condition. The aerodynamic forces in the aeroelastic model are calculated by an AeroDyn module based on blade element momentum theory, and the structural dynamic responses of the blade are calculated using generalized Timoshenko beam theory and geometric exact beam theory. The NREL baseline 5 MW wind turbine and blade properties are used in this study, where the diagonal stiffness parameters and non-diagonal stiffness parameters of the matrixes of each blade section are scaled according to certain principles. The results show that the axial stiffness, the flap-wise stiffness, and the torsional stiffness in the diagonal are sensitive to the root loads and tip displacement of the blade. The flap-wise bending torsion coupling stiffness, the flap-wise shear-torsion coupling stiffness, and the edge-wise shear-torsion coupling stiffness in the non-diagonal are also sensitive to the aeroelastic responses. For completeness, the effects of other stiffness parameters on the aeroelastic responses are also analyzed and discussed.
The Effect of ACTN3 and VDR Polymorphisms on Skeletal Muscle Performance in Axial Spondyloarthropathies
Authors: Pimenta Isabel , Mateus Hugo , Rodrigues-Manica Santiago , Pinheiro-Torres Rita , Neto Agna , Domingues Lúcia , Lage Crespo Carolina , Sardoo Atlas , Machado Pedro , Branco Jaime C. , Silva Susana N. , Pimentel-Santos Fernando M. 
Published: August 2021

BackgroundSpondyloarthritis (SpA) are the most common group of chronic inflammatory rheumatic diseases affecting about 1.5% of the adult Caucasian population. Low back pain is the most common symptom. The aetiopathogenesis of SpA is multifactorial, with well-known genetic and environmental contributions. Furthermore, muscle properties might also be involved in the pathophysiological process and these could be modulated by the genetic background. Alpha-actinin-3 (ACTN3) and Vitamin D receptor (VDR) genes are well-known genes related with muscle performance. Our aim was to analyze four SNPs of these genes and to evaluate their influence in axial SpA (axSpA) susceptibility, phenotype and muscle properties.MethodsWe performed a pilot study based on case-control approach involving 56 participants: 28 axSpA patients and 28 healthy controls matched by age, gender and levels of physical activity. Clinical, epidemiological and muscle characterization data—muscle physical properties (stiffness, tone, and elasticity), strength, mass, and performance, were collected. Two different muscles were considered for analysis, the Multifidus and Gastrocnemius. Four SNPs of ACTN3 (rs1815739) and VDR (rs2228570, rs731236, and rs7975232), were selected, analyzed and correlated with clinical, epidemiological and muscle characterization data.ResultsIn total, 51 individuals (27 axSpA patients and 24 matched controls) were eligible for further genetic analysis, 66.7% being male and with a mean age of 36 years. Muscle physical properties, muscle strength and muscle mass were similar in both groups; however, axSpA patients showed a decrease in muscle performance. None of the studied SNPs were associated with disease susceptibility/phenotype, muscle physical properties, muscle strength or muscle mass. However, ACTN3 rs1815739 and VDR rs2228570 were shown to be associated with muscle performance.ConclusionOur results suggest an association between ACTN3 and VDR polymorphisms and muscle performance in axSpA.
Neurologic Complications in Adult Post-cardiotomy Cardiogenic Shock Patients Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Cohort Study
Authors: Hou Dengbang , Wang Hong , Yang Feng , Hou Xiaotong 
Published: August 2021

Background: This study aims to describe the prevalence of neurologic complications and hospital outcome in adult post-cardiotomy cardiogenic shock (PCS) patients receiving veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support and factors associated with such adverse events.Methods: Four hundred and fifteen adult patients underwent cardiac surgery and received V-A ECMO for more than 24 h because of PCS. Patients were divided into two groups: those who developed a neurological complication and those who did not (control group). Multivariable logistic regression was performed to identify factors independently associated with neurologic complications.Results: Neurologic complications occurred in 87 patients (21.0%), including cerebral infarction in 33 patients (8.0%), brain death in 30 patients (7.2%), seizures in 14 patients (3.4%), and intracranial hemorrhage in 11 (2.7%) patients. In-hospital mortality in patients with neurologic complications was 90.8%, compared to 52.1% in control patients (p &lt; 0.001). In a multivariable model, the lowest systolic blood pressure (SBP) level pre-ECMO (OR, 0.89; 95% CI: 0.86–0.93) and aortic surgery combined with coronary artery bypass grafting (OR, 9.22; 95% CI: 2.10–40.55) were associated with overall neurologic complications. Age (OR, 1.06; 95% CI: 1.01–1.12) and lowest SBP (OR, 0.81; 95% CI: 0.76–0.87) were correlative factors of brain death. Coagulation disorders (OR, 9.75; 95% CI: 1.83–51.89) and atrial fibrillation (OR, 12.19; 95% CI: 1.22–121.61) were shown to be associated independently with intracranial hemorrhage, whereas atrial fibrillation (OR, 8.15; 95% CI: 1.31–50.62) was also associated with cerebral infarction.Conclusions: Neurologic complications in adult PCS patients undergoing V-A ECMO support are frequent and associated with higher in-hospital mortality. Identified risk factors of neurologic complications might help to improve ECMO management and might reduce their occurrence.
A Negative (1,3)-β-D-Glucan Result Alone Is Not Sufficient to Rule Out a Diagnosis of Pneumocystis Pneumonia in Patients With Hematological Malignancies
Authors: Damiani Céline , Demey Baptiste , Pauc Cécile , Le Govic Yohann , Totet Anne 
Published: August 2021

Background: Serum (1,3)-β-D-glucan (BG) testing is increasingly being used in the diagnostic armamentarium for invasive fungal diseases. Given its high sensitivity, some studies suggest that a negative BG result contributes to rule out a diagnosis of Pneumocystis pneumonia (PCP). However, recent reports described a suboptimal sensitivity in HIV-negative immunocompromised patients. In this study, we evaluated the performance of BG assay for PCP diagnosis in HIV-negative patients with diverse PCP risk factors. We also assessed the correlation between Pneumocystis jirovecii load in pulmonary samples and serum BG levels.Methods: We retrospectively included HIV-negative patients with microscopically proven PCP and for whom a BG result was available. We also enrolled patients colonized by Pneumocystis as control group. Colonized patients were matched with PCP patients based on their underlying condition that exposed to PCP. Pulmonary fungal loads were determined by an in-house real-time PCR, and BG levels were measured by using the Fungitell® kit (Associates of Cape Cod, Inc.).Results: Thirty-nine patients were included in each of the two groups. Thirty-four of 39 PCP patients and one of 39 colonized patient had a positive BG test, resulting in a sensitivity of 0.87 (95% CI: 0.73–0.94), a specificity of 0.97 (95% CI: 0.87–0.99), a positive predictive value of 0.97 (95% CI: 0.85–0.99), and a negative predictive value of 0.88 (95% CI: 0.75–0.95) for BG assay. Nonetheless, median BG level differed according to the underlying condition. Among the PCP group, the lowest median level of 211 pg/ml was observed in patients with hematological malignancy (HM) and differed significantly from that observed either in solid organ transplants (3,473 pg/ml) or in patients with autoimmune or inflammatory disorder (3,480 pg/ml). Indeed, the sensitivity of BG assay was estimated at 0.64 (95% CI: 0.35–0.85) in HM patients and was lower than the one observed in the whole PCP group. Furthermore, BG level and fungal burden correlated poorly among all PCP patients.Conclusion: BG is not a reliable biomarker for ruling out PCP in HIV-negative patients with HM. Interpretation of a negative BG result should take into account, but not be limited to, the underlying condition predisposing to PCP.
Serum Cystatin C Predicts Stroke Clinical Outcomes at 1 Year Independent of Renal Function
Authors: Ding Yarong , Liu Liping , Chen Zimo , Li Hao , Pan Yuesong , Wang Junfeng , Meng Xia , Lin Jinxi , Jing Jing , Xie Xuewei , Xiang Xianglong , Wang Yongjun 
Published: August 2021

Objective: Serum cystatin C (CysC) is a sensitive marker of renal function to predict cardiovascular diseases. We aimed to investigate the predictive value of CysC for clinical outcomes independent of renal function in patients with acute ischemic stroke (AIS).Methods: We measured serum CysC levels in 10,256 AIS patients from Third China National Stroke Registry (CNSR-III). The primary outcome was a combination of all-cause mortality and major disability (modified Rankin scale score, 3–6). Secondary outcomes included stroke recurrence and combined vascular events at 1 year. Outcomes were analyzed using logistic regression and Cox proportional hazards models, respectively.Results: The median CysC of included patients was 0.95 mg/l (interquartile range, 0.83–1.10 mg/l). A U-shaped association was observed between CysC and primary outcome (all-cause mortality or major disability) [quartile (Q)1 vs. Q2: adjusted odds ratio (aOR) 1.29, 95% CI 1.06–1.58, p = 0.012; Q3 vs. Q2: aOR 1.12, 95% CI 0.93–1.35, p = 0.242; Q4 vs. Q2: aOR 1.35, 95% CI 1.10–1.65, p = 0.004]. A similar trend also existed in “preserved renal function” patients. Adding CysC to a model containing conventional risk factors improved the model performance with integrated discrimination improvement (IDI) of 0.13% (p = 0.016) and net reclassification index (NRI) of 13.10% (p &lt;0.001) for primary outcome. No significant association was observed for stroke recurrence or combined vascular event rate in different CysC quartiles.Conclusions: CysC showed a U-shaped correlation with 1-year stroke clinical outcome, suggesting that serum CysC may not only be a simple candidate marker of renal function.
Long-Term Vestibular Outcomes in Cochlear Implant Recipients
Authors: Rasmussen Kasper Møller Boje , West Niels , Tian Luchen , Cayé-Thomasen Per 
Published: August 2021

Background: Vestibular dysfunction is likely the most common complication to cochlear implantation (CI) and may, in rare cases, result in persistent severe vertigo. Literature on long-term vestibular outcomes is scarce.Objective: This paper aims to evaluate vestibular dysfunction before and after cochlear implantation, the long-term vestibular outcomes, and follows up on previous findings of 35 consecutive adult cochlear implantations evaluated by a battery of vestibular tests.Methods: A prospective observational longitudinal cohort study was conducted on 35 CI recipients implanted between 2018 and 2019; last follow-up was conducted in 2021. At the CI work-up (T0) and two postoperative follow-ups (T1 and T2), 4 and 14 months following implantation, respectively, all patients had their vestibular function evaluated. Evaluation with a vestibular test battery, involving video head impulse test (vHIT), cervical vestibular evoked myogenic potentials (cVEMP), caloric irrigation test, and dizziness handicap inventory (DHI), were performed at all evaluations.Results: vHIT testing showed that 3 of 35 ears had abnormal vHIT gain preoperatively, which increased insignificantly to 4 of 35 at the last follow-up (p = 0.651). The mean gain in implanted ears decreased insignificantly from 0.93 to 0.89 (p = 0.164) from T0 to T2. Preoperatively, 3 CI ears had correction saccades, which increased to 11 at T2 (p = 0.017). Mean unilateral weakness increased from 19 to 40% from T0 to T2 (p &lt; 0.005), and the total number of patients with either hypofunctioning or areflexic semicircular canals increased significantly from 7 to 17 (p &lt; 0.005). Twenty-nine percent of CI ears showed cVEMP responses at T0, which decreased to 14% (p = 0.148) at T2. DHI total mean scores increased slightly from 10.9 to 12.8 from T0 to T1 and remained at 13.0 at T2 (p = 0.368). DHI scores worsened in 6 of 27 patients and improved in 4 of 27 subjects from T0 to T2.Conclusion: This study reports significant deterioration in vestibular function 14 months after cochlear implantation, in a wide range of vestibular tests. vHIT, caloric irrigation, and cVEMP all measured an overall worsening of vestibular function at short-term postoperative follow-up. No significant deterioration or improvement was measured at the last postoperative follow-up; thus, vestibular outcomes reached a plateau. Despite vestibular dysfunction, most of the patients report less or unchanged vestibular symptoms.
Using Different Cutoffs to Define Tinnitus and Assess Its Prevalence—A Survey in the Dutch General Population
Authors: Rademaker Maaike M. , Smit Adriana L. , Brabers Anne E. M. , de Jong Judith D. , Stokroos Robert J. , Stegeman Inge 
Published: August 2021

Introduction: Tinnitus prevalence numbers in the literature range between 5 and 43%, depending on the studied population and definition. It is unclear when tinnitus becomes pathologic.Objectives: To assess the tinnitus prevalence in the Dutch general population with different cutoffs for definition.Methods: In this cross-sectional study, a questionnaire was sent to a sample (n = 2,251) of the Nivel (Netherlands Institute for Health Services Research) Dutch Health Care Consumer Panel. Three questions were asked to assess the presence of tinnitus, duration, and frequency of the complaint. We classified people as having pathologic tinnitus when participants experienced it for 5–60 min (daily or almost daily or weekly), or tinnitus for &gt;60 min or continuously (daily or almost daily or weekly or monthly), so tinnitus impact on daily life was measured with the Tinnitus Functional Index (TFI) and a single-item question. Answers were stratified to mid-decade years of age. Prevalence numbers were weighted by gender and age to match the Dutch population.Results: Nine hundred thirty-two of 2,251 participants (41%) filled out the questionnaire. The median age was 67.0 (IQR 17) years. Three hundred thirty-eight of 932 (36%) experienced tinnitus for an undefined amount of time during the last year. Two hundred sixteen of 932 (23%) met our definition of having pathologic tinnitus (21% when weighted for age and gender). The median TFI score for all pathologic tinnitus participants was 16.6 (IQR 21.8). A percentage of 50.4% of the pathologic tinnitus participants had a TFI in the range 0–17, which can be interpreted as not a problem.Conclusion: Twenty-three percent (unweighted) or 21% (weighted) of our sample met our definition of pathologic tinnitus, which was based on a combination of duration and frequency over the last year. The TFI score of 47.7% of the pathologic tinnitus participants is ≥18. This indicates that they consider the tinnitus to be at least “a small problem” [11.1% (unweighted) or 8.9% (weighted) of the total study group]. This study illustrates the difficulties with defining pathologic tinnitus. In addition, it demonstrates that tinnitus prevalence numbers vary with different definitions and, consequently, stresses the importance of using a uniform definition of tinnitus.
Clinical Use of a Real-World Low Carbohydrate Diet Resulting in Reduction of Insulin Dose, Hemoglobin A1c, and Weight
Authors: Wolver Susan , Fadel Kristen , Fieger Ethan , Aburish Zein , O'Rourke Brennen , Chandler Toni-Marie , Shimotani Dorian , Clingempeel Natasha , Jain Shuchi , Jain Aashish , Puri Puneet 
Published: August 2021

Introduction: Type 2 Diabetes Mellitus (T2DM) is increasing in epidemic proportions. In addition to the morbidity and mortality, for those treated with insulin, the physical, psychological, and financial tolls are often greater. Our real-world study evaluated a Low Carbohydrate Diet (LCD) in patients with T2DM on insulin with respect to glycemic control, insulin reduction, and weight loss.Materials and Methods: A prospective cohort study was conducted via an Electronic Medical Record search for patients attending the Virginia Commonwealth University Medical Weight Loss Program from 2014 to 2020 with Type 2 Diabetes Mellitus who initially presented on insulin. Data was extracted for 1 year after enrollment. The weight loss program focuses on a LCD.Results: Of 185 participants, the mean (± SD) age was 56.1 (9.9) years. Seventy percent were female and 63% were black. Eighty-five completed 12 months (45.9%), reduced their median (25–75% interquartile range, IQR) insulin dose from 69 to 0 units (0–18, p &lt; 0.0001), HbA1c from 8 to 6.9% (6.2–7.8, p &lt; 0.0001), and weight from 116 to 99 kg (85–120, p &lt; 001). Eighty six percent who completed 12 months were able to reduce or discontinue insulin, with 70.6% completely discontinuing. Among all participants who completed 3, 6, or 12 months, 97.6% were able to reduce or eliminate insulin use.Conclusion: In patients with T2DM on a LCD, it is possible to reduce and even discontinue insulin use while facilitating weight loss and achieving glycemic control. A Low Carbohydrate Diet should be offered to all patients with diabetes, especially those using insulin.