bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Improvement Via Left Angular Gyrus-Navigated Repetitive Transcranial Magnetic Stimulation Inducing the Neuroplasticity of Thalamic System in Alzheimer’s Disease Spectrum Patients
Authors: Yang Zhiyuan , Sheng Xiaoning , Qin Ruomeng , Chen Haifeng , Shao Pengfei , Xu Hengheng , Yao Weina , Zhao Hui , Xu Yun , Bai Feng 
Published: August 2021

Abstract
Background: Stimulating superficial brain regions highly associated with the hippocampus by repetitive transcranial magnetic stimulation (rTMS) may improve memory of Alzheimer disease (AD) spectrum patients. Methods: We recruited 26 mild cognitive impairment (MCI) and AD patients. All the patients were stimulated to the left angular gyrus, which was confirmed a strong link to the hippocampus through neuroimaging studies, by the neuro-navigated rTMS for four weeks. Automated fiber quantification (AFQ) using diffusion tensor imaging (DTI) metrics and graph theory analysis on functional network were employed to detect the neuroplasticity of brain networks. Results: After neuro-navigated rTMS intervention, the episodic memory and language function of patients were significantly improved. Increased white matter integrity of right anterior thalamic radiation among MCI patients, while decreased functional network properties of thalamus subregions were observed. It is worth noting that the improvement of cognition was associated with the neuroplasticity of thalamic systemConclusions: We speculated that the rTMS intervention targeting left angular gyrus may be served as a strategy to improve cognitive impairment in AD spectrum patients, supporting by the neuroplasticity of thalamic system, especially in the early disease process at the stage of MCI.
Adjuvant Trastuzumab with or without Chemotherapy in Stage 1 pT1N0 HER2+ Breast Cancer: A National Cancer Database Analysis
Authors: Cao Lifen , Shenk Robert , Stabellini Nickolas , Miller Megan E. , Towe Christopher W. , Montero Alberto J. 
Published: August 2021

Abstract
Purpose: Approximately 20% of all breast cancers (BC) are HER2 amplified. In the APT trial, weekly paclitaxel/ trastuzumab in node negative HER2+ BC with tumors <3 cm was associated with a 7-year invasive disease-free survival of 93%. However, this was in the context of a non-randomized trial, and for pT1N0 HER2+ BC it remains unclear whether HER2 monotherapy would provide similar clinical outcomes to chemo-HER2 therapy. We hypothesized that adjuvant chemo-HER2 therapy would be associated with a modestly improved overall survival compared to HER2 monotherapy in patients with tumors <2cm. Methods: In the National Cancer Database (2004-2017), patients with a primary diagnosis of pT1N0M0 HER2+ BC, were separated into two groups: (i) HER2 monotherapy, i.e. trastuzumab, and (ii) chemo-HER2 therapy. A 3:1 propensity match was performed to balance patient selection bias between the two different cohorts. Long-term overall survival (OS) was compared between both groups. Results: A total of 23, 281 patients met the criteria. 22,268 (96.7%) received chemo-HER2 therapy and 1,013 (4.4%) received HER2 monotherapy. Propensity match identified 1,995 patients who received chemo-HER2 therapy, and 666 who received HER2 monotherapy. After match, adjuvant chemo-HER2 therapy was associated with a modest survival advantage over HER2 monotherapy (5-year OS 94.1% vs. 90.6%, P=0.041). Conclusions: Even though there is a modest OS advantage favoring adjuvant chemo-HER2 therapy in pT1N0 HER2+ BC, HER2 monotherapy was associated with 5-year OS >90%. Therefore, in select patients who have contraindications for cytotoxic chemotherapy, or decline adjuvant chemotherapy, adjuvant trastuzumab monotherapy appears to be a reasonable alternative.
A case study of Web Content Accessibility of 15 top-ranked Universities of India
Authors: Kumar Akhilesh 
Published: August 2021

Abstract
Accessibility of websites are very important for making it web-based information for persons with disabilities which further reinforced by COVID-19 pandemic. Web Content Accessibility Guidelines (WCAG) has been developed by World Wide Web Consortium (W3C) and accordingly Guidelines for Indian Government Websites (GIGW) has also been developed. In this case study we studied the home page of websites of 15 top ranked Higher Education Institutions of India ranked by National Institutional Ranking Framework (NIRF), started in 2016 for availability of basic accessibility features. The ranking used is of latest one i.e. of 2020. Qualitative observation has been made of the home page of each 15 universities and the NIRF website. Eleven fundamental accessibility features were taken in to account. Results revealed that most of these top15 ranked universities lack even basic accessibility feature making their websites inaccessible for persons with disabilities. Options like font size, screen reader, high contrast text also were not found on may website of top-15 universities. The website of NIRF had no basic features out of 11 considered in the study indicating a very poor condition of digital accessibility features of website of top ranked universities which needs urgent attention to achieve equity and inclusion as promised in NEP 2020.
A Primary Cardiac Osteosarcoma: Case Report and Literature Review
Authors: Zou Xue-Xue , Chang Wen-Li , Gao Heng-Xing 
Published: August 2021

Abstract
Background: Primary cardiac osteosarcoma is an uncommon condition, which is challenging to diagnose, and rarely reported.Case presentation: Here, we present a previously healthy 27-year-old patient referred to our hospital with a long-term fever. Echocardiography and thoracic computed tomography (CT) presented two masses in the left atrium (LA) and left ventricle (LV), and surgical excision of the masses revealed cardiac high-grade osteosarcoma. Unfortunately, the left ventricular tumor recurred three months later, and the patient was administered periodic chemotherapy. Then, chest CT showed that the left ventricle was almost occupied by the tumor and also involved the left ventricular outflow tract, the left atrial appendage mass increased significantly, and multiple metastatic small nodules appeared in both lungs.The patient is still in follow-up.Conclusions: The prevalence of primary cardiac osteosarcoma is very low and did not involve LA and LV simultaneously. This patient was hospitalized in our hospital complaining of a long-term fever of unknown origin, which has never been reported in the previous literatures. Our case report findings suggest that primary cardiac osteosarcoma should not be ignored in the differential diagnosis of fever of unknown origin.
Isolation and Characterization of Potential Bacteriocin Producing Lactic Acid Bacteria From Fermented Food Products
Authors: Keerthini S. , Kapilan R. , Vasantharuba S. 
Published: August 2021

Abstract
BackgroundProbiotic, Lactic Acid Bacteria (LAB) are consumed by human through the traditional food products for several decades due to their beneficial health effects. LAB is Gram positive, non motile bacteria that produce antimicrobial peptides for their defense mechanism. Among the antimicrobial peptides, Bacteriocins are widely investigated because of their possible utilization in food sector especially food security actions, where bacteriocin kills or inhibits the growth of other bacteria. Usage of metabolic products of LAB and LAB are generally recognized as safe. Therefore, this study was aimed to isolate LAB species that produce bacteriocin showing wide spectrum antibacterial activity.Results Lactic acid bacteria were isolated from yoghurt, curd, dosa batter, idli batter and soaked and ground rice batter using (De Man, Rogosa and Sharpe agar) MRS agar and incubated at room temperature (30±2ºC) for 24-72 h aerobically and anaerobically. When agar well diffusion method was employed to detect the antibacterial activity of the twenty five isolates against food spoilage organisms (Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, E.coli, Klebsiella pneumoniae, Serratia marcescens, Salmonella sp., Proteus sp., Micrococcus sp., and Bacillus sp.,). Three bacterial species showing broad spectrum of antibacterial activity, were identified and characterized by biochemical and molecular methods. The wide spectrum antibacterial bacterial species were identified as Lactobacillus reuteri AF182723 isolated from curd, Lactobacillus rhamnosus AY299488 isolated from rice batter and Lactobacillus acidophilus AF182726 isolated from yoghurt. Among all the isolates, Lactobacillus reuteri AF182723 showed significant wide spectrum antibacterial activity against diverse Gram positive and Gram negative bacterial species. Conclusion The production of bacteriocin from Lactobacillus reuteri AF182723 and incorporating it in the food would inhibit the food spoilage organisms. Usage of this bacteriocin at appropriate concentration in food needs to be studied further.
Dipolar excitonic insulator in a moiré lattice
Authors: Gu Jie , Ma Liguo , Liu Song , Watanabe Kenji , Taniguchi Takashi , Hone James , Shan Jie , Mak Kin Fai 
Published: August 2021

Abstract
Two-dimensional (2D) moiré materials provide a highly-controllable solid-state platform for studies of correlated quantum phenomena. To date, experimental studies have focused on the correlated electronic states; the correlated bosonic states in moiré materials have remained practically unexplored. Here, we report a correlated dipolar excitonic insulator--a charge insulating state driven by exciton formation--in a Coulomb-coupled WSe2 monolayer and WSe2/WS2 moiré bilayer at total hole doping density equal to the moiré density. The system is a Mott insulator when all the holes reside in the moiré layer. Under an out-of-plane electric field, the holes can be continuously transferred to the WSe2 monolayer, but remain strongly bound to the empty moiré sites. This is effectively an interlayer exciton fluid in the moiré lattice under a particle-hole transformation. We identify the phase space and determine the charge gap energy of the excitonic insulating state by optical spectroscopy and capacitance measurements, respectively. We further observe the emergence of local magnetic moments in the WSe2 monolayer induced by the strong interlayer Coulomb correlation. Our result paves the path for realizing correlated bosonic quantum phenomena described by the Bose-Hubbard model in a solid-state system.
Work Stress and Loss of Years Lived Without Chronic Disease: an 18-year Follow-up of 1.5 Million Employees in Denmark
Authors: Sørensen Jeppe Karl , Framke Elisabeth , Pedersen Jacob , Alexanderson Kristina , Bonde Jens P. , Farrants Kristin , Flachs Esben M. , Hanson Linda L. Magnusson , Nyberg Solja T. , Kivimäki Mika , Madsen Ida E. H. , Rugulies Reiner 
Published: August 2021

Abstract
We aimed to examine the association between exposure to work stress and chronic disease incidence and loss of chronic disease-free life years in the Danish workforce. The study population included 1,592,491 employees, aged 30 to 59 in 2000 and without prevalent chronic diseases. We assessed work stress as the combination of job strain and effort-reward imbalance using job exposure matrices. We used Cox regressions to estimate risk of incident hospital-diagnoses or death of chronic diseases (i.e., type 2 diabetes, coronary heart disease, stroke, cancer, asthma, chronic obstructive pulmonary disease, heart failure, and dementia) during 18 years of follow-up and calculated corresponding chronic disease-free life expectancy from age 30 to age 75. Individuals working in occupations with high prevalence of work stress had a higher risk of incident chronic disease compared to those in occupations with low prevalence of work stress (women: HR 1.04 (95% CI 1.02 to 1.05), men: HR 1.12 (95% CI 1.11 to 1.14)). The corresponding loss in chronic disease-free life expectancy was 0.25 (95% CI -0.10 to 0.60) and 0.84 (95% CI 0.56 to 1.11) years in women and men, respectively. Additional adjustment for health behaviours attenuated these associations among men. We conclude that men working in high-stress occupations have a small loss of years lived without chronic disease compared to men working in low-stress occupations. This finding appeared to be partially attributable to harmful health behaviours. In women, high work stress indicated a very small and statistically non-significant loss of years lived without chronic disease.
Optimal Low-Density Lipoprotein Cholesterol Levels In Adults Without Diabetes Mellitus: A Nationwide Population-Based Study Including More Than 4 Million Individuals From South Korea
Authors: Huh Ji Hye , Park Sang Wook , Go Tae-Hwa , Kang Dae Ryong , Lee Sang-Hak , Kim Jang Young 
Published: August 2021

Abstract
Background: Although the strong association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD) is well-known, the threshold LDL-C level at which the risk of CVD begins to increase in individuals without diabetes mellitus (DM) remains unknown. We aimed to evaluate the association between incident CVD and serum LDL-C levels with or without statin use in individuals without DM. Methods: We identified 4,182,117 individuals without previous CVD who underwent a health screening examination in 2009 and 2011 from the Korean National Health Insurance Cohort database. The primary endpoint was a composite of cardiovascular deaths, myocardial infarction (MI) cases, and ischemic stroke cases. Results: During the median follow-up of 6 years, there were 51,961 CVD events that included 17,392 MI cases, 33,779 ischemic stroke cases, and 2,039 cardiovascular deaths. The LDL-C levels that were associated with an increased risk of CVD were ≥100 mg/dL in non-statin users and ≥130 mg/dL in statin users. However, even in individuals with lower LDL-C levels, all those with fasting plasma glucose (FPG) levels ≥110 mg/dL had a significantly higher risk of CVD.Conclusions: We demonstrated that LDL-C levels ≥100 mg/dL were correlated with an increased risk of CVD in individuals without DM and a history of CVD. We found that a glucose, cholesterol interaction increased CVD risk, and modestly elevated FPG levels (110–125 mg/dL) were associated with a higher CVD risk even in individuals with well-controlled LDL-C levels.
68Ga-DOTA-DiPSMA PET/CT Imaging: Biodistribution, Dosimetry and First Comparison with 68Ga-PSMA-11 in Prostate Cancer
Authors: Zhang Jiaying , Lin Zefang , Zhang Xiaojun , Lin Rong , Cui Mengchao , Zang Jie , Miao Weibing , Yao Shaobo 
Published: August 2021

Abstract
PurposeThis prospective trial aimed to evaluate the safety, dosimetry, biodistribution, and diagnostic efficacy of a novel theranostic probe 68Ga-DOTA-DiPSMA. Also, we have performed the first comparison with 68Ga-PSMA-11 in prostate cancer (PCa) patients.MethodsFive healthy volunteers and ten PCa patients with a previous clinical 68Ga-PSMA-11 PET/CT were injected with an intravenous bolus of 68Ga-DOTA-DiPSMA with a dose of 1.85MBq/kg. Healthy volunteers received serial whole-body PET scans from the time of injection up to 60 min post-injection, with a second PET/CT scanning at 120 min post-injection. In PCa patients, low-dose CT scan, whole-body PET was performed with 2 min per bed position in 40 min post-injection. In addition, 68Ga-PSMA-11 scanning was performed on PCa patients within 10 days under the same acquisition procedure. Absorbed organ doses and effective doses were calculated using OLINDA/EXM. Normal organ uptake and tumor lesion uptake (SUVmax) were measured. A lesion-by-lesion analysis was performed.Results﻿68Ga-DOTA-DiPSMA administration was safe and well-tolerated. The kidneys received the highest absorbed dose (114.46 ± 29.28 uSv/MBq), followed by the urinary bladder wall (100.82 ± 46.22 uSv/MBq) in accordance with the expected PSMA renal excretion of the tracer. The mean effective dose was 19.46 ± 1.73 μSv/MBq. The SUVmax of ﻿68Ga-PSMA-11 and 68Ga-DOTA-DiPSMA PET/CT for PCa lesions, bone metastases, and lymph node metastases were 11.2 ± 10.76 vs. 4.41 ± 2.72, 7.6 ± 1.58 vs. 2.95 ± 1.11 and 4.86 ± 1.94 vs. 3.26 ± 1.2, respectively.ConclusionInjection of ﻿68Ga-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Compared to 68Ga-PSMA-11, 68Ga-DOTA-DiPSMA shows comparable pharmacokinetics and detection ability in PCa patients that warrant further head-to-head comparison. Low non-specific uptake in salivary glands and kidneys of 68Ga-DOTA-DiPSMA indicates potential radioligand therapy (RLT) application when labeled with 177Lu, 90Y, or 225Ac.
Learners and System Readiness for Digital Learning in Ethiopian Health Sector: The Path to Blended Learning
Authors: Berhan Yifru , Dessalegn Muluken , Hetyey Aranka , Assamnew Bekalu , Tsegaye Sentayehu , Makonnen Misrak , Abebe Sintayehu 
Published: August 2021

Abstract
BackgroundIn Ethiopia, the traditional face-to-face learning method is still the predominant modality to formally educate and train health workers in many universities and colleges, but could not alleviate the critical national shortage of health workforce. The increasing global digital interconnectedness, the emerging user-friendly and cost-effective digital learning platforms are easing the barriers for reaching unlimited audience, and the lessons learned from coronavirus disease (COVID-19) restrictions have opened room for digital learning. Therefore, the purpose of this study was to get an insight into the learners and system readiness for digital learning scale up.MethodsQuantitative and qualitative methods were employed by including 393 lower and mid-level health workers from regional states and Addis Ababa city, and 27 key informants from different governmental and non-governmental organizations. The market appetite for digital learning, willingness to pay, use of the mobile devices, delivery mode preference, and the current context pertinent to digital learning were assessed. ResultsAlmost all of the study participants possessed mobile phones, and the majority (92%) had smartphones. Most of those who had digital learning experience agreed or strongly agreed with digital learning is cost-effective (88.7%), most effective and efficient (90.3%) with no geographic limitation (95.2%), easier to use (91.9%), and enabling the required skills and knowledge (89%) as compared to face-to-face learning, which were also supported by key informants. More than 90% of survey participants with digital learning experience regarded classroom learning as more expensive than digital learning and the majority were willing to pay for digital learning service, which was also echoed by key informants. The most preferred delivery mode was blended learning. ConclusionStudy participants have expressed their optimism towards digital learning, most preferably through a blended delivery mode. The cost-effectiveness of the method, high access to mobile devices, government and partners’ commitment along with trainees preference are persuasive conditions to implement and transform digital learning for health workers in Ethiopia and increase the health workforce as an important intervention for achieving universal health coverage and health-specific sustainable development goals at large.
Relationship between lipid accumulation product index and arterial stiffness in the Chinese population with hypertension: a report from the China Hypertension Registry Study
Authors: Shi Yumeng , Hu Lihua , Li Minghui , Zhou Wei , Wang Tao , Zhu Lingjuan , Bao Huihui , Li Ping , Cheng Xiaoshu 
Published: August 2021

Abstract
Background: The relation of LAP index with baPWV have been evaluated in several previous studies and yield inconsistent results. The aim of the study was to investigate the association between the lipid accumulation product (LAP) index and arterial stiffness in the Chinese population with hypertension.Methods: We conducted a cross-sectional analysis in 4926 participants chinese population with hypertension (aged 64.42 ± 9.44years). The LAP was developed from population-based frequency plots of adult waist circumferences and circulating triglyceride concentrations. Arterial stifness was determined by measuring brachial-ankle pulse wave velocity (baPWV).Results: Multivariate linear regression analyses showed that LAP index was independently and positively associated with baPWV (β, 25.06 cm/s (95% confdence interval [CI]: 10.91, 39.22 cm/s). Consistently, Multiple logistic analyses showed a positive association between LAP index risk of elevated baPWV (>75th percentile) (odds ratio [OR], 1.24; 95% CI 1.09, 1.40). A restricted cubic spline showed that the significant linear association existed between LAP index and baPWV. Similar results were found in various subgroups.Conclusion: LAP is a signifcant positive associated with with baPWV and elevated baPWV in Chinese hypertensive adults.
Nonmetallic plasmonic heterostructures with multi-synergies on boosting hot electron generation for CO2 photoreduction
Authors: Lou Zaizhu , Lu Changhai , Li Xinru , Li Juan , Mao Liang , Wang Xuandong , Chen Qin , wen long , Zhu Mingshan , Li Baojun 
Published: August 2021

Abstract
Constructing multi-physical effects on semiconductors is one new horizon to develop next-generation photocatalysts. Here we use pyroelectric black phosphorus (BP) to couple with nonmetallic plasmonic tungsten oxides (WO) forming a BP/WO heterostructures as photocatalysts to convert CO2 for CO under visible-near-infrared (Vis-NIR) light irradiation. Nonmetallic plasmonic heterostructures exhibit 26.1 µmol h− 1 g− 1 CO generation with a selectivity of 98 %, and which is 7- and 17-fold higher than those of plasmonic WO and pyroelectric BP, respectively. The interface P-O-W bonds in heterostructures are constructed to work as channels for electron transfer from BP to plasmonic WO. Moreover, the photothermal energy generated by SPR excitation on WO can make the temperature of heterostructures rapidly increasing from 24 to 86 oC in 10 min, triggering the pyroelectric BP for carriers to promote electron transfer. Multi-physical effects including plasmonic hot carriers and photothermal effect of WO, intrinsic band excitation and pyroelectric effect of BP and W-O-P bonds play synergistic roles on boosting hot electron generation for CO2 reduction. This work provides clear proofs to demonstrate that constructing multi-physical effects on semiconductors is one useful strategy to promote NIR-harvesting for artificial photosynthesis.