bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA SNHG6/miR-125b-5p/BMPR1B Axis: A New Therapeutic Target for Triple-Negative Breast Cancer
Authors: Lv Yufei , Lv Xiaohong , Yang Huike , Qi Xiuying , Wang Xiangchen , Li Chao , Shang Xiaochen , Guo Hongmin , Zhang Jianguo , Zhang Yafang 
Published: May 2021

BackgroundTriple-negative breast cancer (TNBC) is a significant cause of patient morbidity. The exactly pathobiological features of this condition has yet to be completely elucidated.MethodsBreast cancer data obtained from The Cancer Genome Atlas (TCGA) database were evaluated for lncRNA SNHG6 expression. Normal human breast epithelial cell line (MCF-10A) and other breast cancer cell lines (BT-549, MDA-MB-231, Hs 578t, ZR-75-30, SK-BR-3, MCF-7) were also assessed for lncRNA SNHG6 expressions. Cellular proliferative ability was evaluated with colony formation and CCK-8 assays. The ability of cells to migrate was scrutinized with the wound healing and Boyden chamber cell migration assays. qRT-PCR enabled for detection of lncRNA SNHG6, miR-125b-5p and BMPR1B mRNA expressions. Protein BMPR1B expressions were further assessed using Western Blotting. Direct binding sites between transcripts were determined using dual-luciferase reporter assays. We also constructed a xenograft mouse model to further dissect the vivo implications of lncRNA SNHG6. Ki-67 and c-Caspase-3 expressions were detected using immunohistochemistry staining.ResultsBreast cancer cell lines demonstrated higher lncRNA SNHG6 expressions, particularly TNBC cell lines, in contrast to normal breast epithelial cell lines. This finding coincided with those noted on analysis of TCGA breast cancer data. lncRNA SNHG6 knockdown inhibited TNBC cell proliferation, migration, while promoted cell apoptosis. Furthermore, suppressed lncRNA SNHG6 expressions resulted in lower tumor weights and volumes in a xenograft mouse model, as evidenced by Ki-67 and c-Caspase-3 expression profiles in tumor tissues. miR-125b-5p and lncRNA SNHG6/BMPR1B both possessed direct binding sites for each other which was validated utilizing a dual-luciferase reporter assay. Decreasing lncRNA SNHG6 expression in TNBC cells upregulated miR-125b-5p expression. Another side, inhibiting miR-125b-5p upregulated BMPR1B expression in these cells. Moreover, knocking down lncRNA SNHG6 downregulated BMPR1B expression in TNBC cells, and the finding was rescued in cells which were exposed to miR-125b-5p inhibitor. Downregulating miR-125b-5p mitigated the effect of suppressing lncRNA SNHG6 on TNBC cell proliferation, migration, and apoptosis.ConclusionDownregulation of lncRNA SNHG6 could inhibit TNBC cell proliferative, migratory capabilities and promote apoptosis capability, likely through modulation of the miR-125b-5p/BMPR1B axis. This axis may be targeted in formulating new therapies for TNBC.
Changes in Urologic Operative Practice at the Beginning of the COVID-19 Pandemic in a Large, National Cohort
Authors: Lewicki Patrick , Arenas-Gallo Camilo , Basourakos Spyridon P. , Punjani Nahid , Venkat Siv , Scherr Douglas S. , Hu Jim C. , Shoag Jonathan E. 
Published: May 2021

ObjectiveTo analyze population-level changes in operative practice since the onset of the COVID-19 pandemic to contextualize observations made by individual practices and optimize future responses.Materials and MethodsThis US retrospective analysis used the Premier Perspectives Database. We investigated changes in operative volume through March 2020. Baseline operative volume for urologic surgery was calculated using data from the preceding 12 months and compared on a total and by procedure basis. Multivariable linear regression was used to identify hospital-level predictors of change in response to the pandemic.ResultsAt baseline, we captured 23,788 urologic procedural encounters per month as compared with 19,071 during March 2020– a 19.9% decrease. Urologic oncology-related cases were relatively preserved as compared to others (average change in March 2020: +1.1% versus -32.2%). Northeastern (β = -5.66, 95% confidence interval [CI]: -10.2 to -1.18, p = 0.013) and Midwestern hospitals (β = -4.17, 95% CI: -7.89 to -0.45, p = 0.027; both with South as reference region), and those with an increasing percentage of patients insured by Medicaid (β= -0.17 per percentage point, 95% CI: -0.33 to -0.01, p = 0.04) experienced a significantly larger decrease in volume.ConclusionsThere was a 20% decline in urologic operative volume in March 2020, compared with baseline, that preferentially affected hospitals serving Medicaid patients, and those in Northeast and Midwest. In the face of varying mandates on elective surgery, widespread declines in operative volume may also represent hesitancy on behalf of patients to interface with healthcare during the pandemic.
Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats
Authors: Gáspár Attila , Hutka Barbara , Ernyey Aliz Judit , Tajti Brigitta Tekla , Varga Bence Tamás , Zádori Zoltán Sándor , Gyertyán István 
Published: May 2021

Intracerebroventricularly injected streptozotocin (STZ)-induced learning impairment has been an increasingly used rat model of Alzheimer disease. The evoked pathological changes involve many symptoms of the human disease (cognitive decline, increase in β-amyloid and phospho-tau level, amyloid plaque-like deposits). However, the model has predominantly been used with Wistar rats in the literature. The objective of the current study was to transfer it to Long-Evans rats with the ulterior aim to integrate it in a complex cognitive test battery where we use this strain because of its superior cognitive capabilities. We performed two experiments (EXP1, EXP2) with three months old male animals. At EXP1, rats were treated with 2 × 1.5 mg/kg STZ (based on the literature) or citrate buffer vehicle injected bilaterally into the lateral ventricles on days 1 and 3. At EXP2 animals were treated with 3 × 1.5 mg/kg STZ or citrate buffer vehicle injected in the same way as in EXP1 at days 1, 3, and 5. Learning and memory capabilities of the rats were then tested in the following paradigms: five choice serial reaction time test (daily training, started from week 2 or 8 post surgery in Exp1 or Exp2, respectively, and lasting until the end of the experiment); novel object recognition (NOR) test (at week 8 or 14), passive avoidance (at week 11 or 6) and Morris water-maze (at week 14 or 6). 15 or 14 weeks after the STZ treatment animals were sacrificed and brain phospho-tau/tau protein ratio and β -amyloid level were determined by western blot technique. In EXP1 we could not find any significant difference between the treated and the control groups in any of the assays. In EXP2 we found significant impairment in the NOR test and elevated β-amyloid level in the STZ treated group in addition to slower learning of the five-choice paradigm and a trend for increased phospho-tau/tau ratio. Altogether our findings suggest that the Long-Evans strain may be less sensitive to the STZ treatment than the Wistar rats and higher doses may be needed to trigger pathological changes in these animals. The results also highlight the importance of strain diversity in modelling human diseases.
Ultrasound-Guided Hydrodilatation With Triamcinolone Acetonide for Adhesive Capsulitis: A Randomized Controlled Trial Comparing the Posterior Glenohumeral Recess and the Rotator Cuff Interval Approaches
Authors: Wang Jia-Chi , Tsai Po-Yi , Hsu Po-Cheng , Huang Jian-Ru , Wang Kevin A. , Chou Chen-Liang , Chang Ke-Vin 
Published: May 2021

For patients with adhesive capsulitis, hydrodilatation is typically performed using corticosteroids with ultrasound guidance via the posterior glenohumeral recess. Recently, a new intervention technique via the rotator cuff interval has been described. This study aimed to compare the efficacy of hydrodilatation with triamcinolone acetonide via the posterior glenohumeral recess and the rotator cuff interval in patients with adhesive capsulitis. This prospective randomized controlled trial was conducted in a tertiary care center with a follow-up period of 12 weeks. We enrolled 64 patients diagnosed with shoulder adhesive capsulitis. The subjects were randomly assigned to two groups that received hydrodilatation with corticosteroids either through the posterior glenohumeral recess or though the rotator cuff interval. The injection contained 4 ml of triamcinolone acetonide (40 mg) mixed with 4 ml of 2% lidocaine hydrochloride and 12 ml of normal saline. The shoulder pain and disability index, visual analog scale for pain, and range of motion were analyzed before and at 6 and 12 weeks after the treatment. Both groups experienced improvements in the visual analog scale scores, shoulder pain and disability index scores, and range of motion throughout the study period. A significant group-time interaction was observed in terms of the visual analog scale for pain during motion (p = 0.019), favoring hydrodilatation through the rotator cuff interval. Thus, hydrodilatation through the rotator cuff interval might be a better treatment option than that through the posterior glenohumeral recess for patients with adhesive capsulitis, considering its superior effect in alleviating pain during shoulder movement.
An Exploratory Meta-Analytic Review on the Empirical Evidence of Differential Learning as an Enhanced Motor Learning Method
Authors: Tassignon Bruno , Verschueren Jo , Baeyens Jean-Pierre , Benjaminse Anne , Gokeler Alli , Serrien Ben , Clijsen Ron 
Published: May 2021

Background: Differential learning (DL) is a motor learning method characterized by high amounts of variability during practice and is claimed to provide the learner with a higher learning rate than other methods. However, some controversy surrounds DL theory, and to date, no overview exists that compares the effects of DL to other motor learning methods.Objective: To evaluate the effectiveness of DL in comparison to other motor learning methods in the acquisition and retention phase.Design: Systematic review and exploratory meta-analysis.Methods: PubMed (MEDLINE), Web of Science, and Google Scholar were searched until February 3, 2020. To be included, (1) studies had to be experiments where the DL group was compared to a control group engaged in a different motor learning method (lack of practice was not eligible), (2) studies had to describe the effects on one or more measures of performance in a skill or movement task, and (3) the study report had to be published as a full paper in a journal or as a book chapter.Results: Twenty-seven studies encompassing 31 experiments were included. Overall heterogeneity for the acquisition phase (post-pre; I2 = 77%) as well as for the retention phase (retention-pre; I2 = 79%) was large, and risk of bias was high. The meta-analysis showed an overall small effect size of 0.26 [0.10, 0.42] in the acquisition phase for participants in the DL group compared to other motor learning methods. In the retention phase, an overall medium effect size of 0.61 [0.30, 0.91] was observed for participants in the DL group compared to other motor learning methods.Discussion/Conclusion: Given the large amount of heterogeneity, limited number of studies, low sample sizes, low statistical power, possible publication bias, and high risk of bias in general, inferences about the effectiveness of DL would be premature. Even though DL shows potential to result in greater average improvements between pre- and post/retention test compared to non-variability-based motor learning methods, more high-quality research is needed before issuing such a statement. For robust comparisons on the relative effectiveness of DL to different variability-based motor learning methods, scarce and inconclusive evidence was found.
Acquired Brain Injury and Interventions in the Offender Population: A Systematic Review
Authors: de Geus Esther Q. J. , Milders Maarten V. , van Horn Joan E. , Jonker Frank A. , Fassaert Thijs , Hutten Juliette C. , Kuipers Femke , Grimbergen Christel , Noordermeer Siri D. S. 
Published: May 2021

Background and Aims: The prevalence of acquired brain injury (ABI) in offender populations appears much higher than in the general population, being estimated at 50% compared to 12%, respectively. Taking into account ABI-related cognitive and social impairments or behavioral changes in forensic treatments might be relevant and may improve treatment outcomes. The aim of the current review is to summarize and integrate the literature on psychological interventions or treatments for consequences of ABI in the forensic setting. Reviewing this literature could provide crucial information for improving treatment options for offenders with ABI, which may contribute to reducing recidivism.Methods: The PubMed/MEDLINE, PsychInfo, CINAHL, COCHRANE, and Web of Science databases were searched for studies in adult offenders with ABI that evaluated the effect of psychological interventions with a focus on ABI-related impairments and recidivism.Results: This review identified four intervention studies that met the inclusion criteria. These included an adult population (≥18-year-old) in a forensic setting (given the focus of the current review on treatment, defined here as an environment in which offenders are treated while being incarcerated or as outpatients), non-pharmacological treatments and were published in English or Dutch between 2005 and 2020. All studies reported some positive effects of the intervention on interpersonal behavior, cognition and recidivism. The aspects of the interventions that seemed most beneficial included personalized treatment and re-entry plans, support for the individual and their environment and psychoeducation about the effects of ABI.Discussion: Although positive effects were reported in the studies reviewed, all studies had methodological limitations in terms of sample size, study design and outcome measures which affects the strength of the evidence. This limits strong conclusions and generalizability to the entire offender population.Conclusion: Despite high prevalence of ABI in offender populations, interventions in forensic settings seldom address the effect of ABI. The few studies that did take ABI into account reported positive effects, but those results should be interpreted with caution. Future studies are warranted, since this does seem an important venue to improve treatment, which could eventually contribute to reducing recidivism.
Sciatic Herpes Zoster Suspected of Lumbar Disc Herniation: An Infrequent Case Report and Literature Review
Authors: Wei Fei-Long , Li Tian , Song Yang , Bai Lin-Ya , Yuan Yifang , Zhou Chengpei , Qian Jixian , Yan Xiaodong 
Published: May 2021

Background: The symptoms of sciatic herpes zoster are sometimes difficult to distinguish from sciatica caused by lumbar disc herniation. We describe a case of suspected lumbar disc herniation with sciatic herpes zoster to reduce the rate of misdiagnosis.Case Report: A 55-year old man, male, developed low back pain after carrying heavy items 20 years ago. Characteristics of symptoms: 1. Symptoms were aggravated in the upright lumbar forward flexion position; 2. The VAS (leg) score was 8–9 points and the VSA (lumbar) score was 0 point; 3. It can be relieved when rested in the supine position; 4. It came on intermittently with radiation pain in the right lower limb. There were several attacks every year. One month ago, there was radiating pain in the right lower limb. The pain was from the back of the right hip, behind the thigh, in lateral crural region, to the back of the foot. And Symptoms worsened for 10 days. The VAS score was 8 points. Pain could not be relieved by rest or changing posture. There was no back pain, no lower limbs, weak walking, no claudication and other symptoms. Analgesics and neurotrophic drugs are ineffective. After the application of antiviral drugs, the radiation pain in the right lower extremity was significantly relieved.Conclusion: We describe this case in detail and discuss how to make an authentic diagnosis, with a concomitant literature review.
Energy Drink Consumption Among Finnish Adolescents: Prevalence, Associated Background Factors, Individual Resources, and Family Factors
Authors: Puupponen Maija , Tynjälä Jorma , Tolvanen Asko , Välimaa Raili , Paakkari Leena 
Published: May 2021

Objectives: Energy drink consumption among adolescents has become a notable global phenomenon, and has been associated with numerous negative health outcomes. In order to understand the popularity of energy drinks among adolescents, and to target interventions, it is important to identify the determinants underpinning consumption.Methods: The nationally representative data (cross-sectional) were drawn from the Health Behaviour in School-aged Children (HBSC) surveys, conducted in 2014 and 2018, each comprising 13- and 15-year-old Finnish adolescents (n = 7405).Results: Weekly energy drink consumption increased among Finnish adolescents between 2014 (18.2%) and 2018 (24.4%), especially among girls. In 2018, boys typically consumed more than girls, and 15-year-olds more than 13-year-olds. Moreover, in 2018, weekly energy drink consumption was more prevalent among 15-year-old adolescents with a non-academic educational aspiration (46.0%) than among adolescents with an academic aspiration (18.3%). Gender (boys more than girls), older age (only in 2018), less parental monitoring, lower school achievement, and a lower level of health literacy explained around 28% of the variance in weekly energy drink consumption in both years.Conclusion: According to the findings, interventions to decrease the energy drink consumption, should be targeted at all adolescents, but especially at those with fewer individual resources. The interventions should also pay attention to family-level factors.
La notion d’archaïsme à Rome : l’exemple des formules de prières latines
Authors: Guittard Charles 
Published: May 2021

religious archives have disappeared and we have only recent data. But some data are given (Iguvine Tables, prayers included in the De agricultura of Cato, rituals preserved by Livy and Macrobius : ritual of the fetials,
evocatio, devotio ; the hymns of the Salii and of the Arvales). If the carmina were quite incomprehensible for the Romans and are also incomprehensible for us, the prayers were clearly understood by the Romans. The prayers formulas were constantly adapted and modernized, in order to be comprehensible by the men and by the gods themselves.
Le statut des périèques lacédémoniens
Authors: Ducat Jean 
Published: May 2021

Première partie : la nature des établissements périèques. L’examen d’une série d’indices montre que, si certains n’étaient probablement que des komai (soit de Sparte, soit de cités périèques), la plupart de ceux que nous connaissons avaient le statut de cités. Cela est confirmé par la façon dont les textes les présentent quand ils les considèrent dans leur ensemble. Deuxième partie : nature et limites de la dépendance des cités périèques.
Dans le domaine militaire, elles dépendent entièrement de Sparte ; mais cela n’empêche pas certaines d’entre elles d’avoir des relations avec des cités de l’extérieur, comme le montre la présence en leur sein de proxènes. Les relations particulières qu’elles ont avec les rois de Sparte ne doivent pas être conçues comme des relations de dépendance. Ce qui, à nos yeux comme à ceux des Anciens, marque le plus clairement cette dépendance, c’est la faculté qu’avaient les autorités de Sparte, essentiellement les éphores, d’intervenir, quand elles le jugeaient nécessaire, dans leurs affaires intérieures. Troisième partie : l’ensemble lacédémonien. Contrairement à l’opinion courante, il n’existait pas de «cité de Lacédémone» , dont les Périèques auraient été des membres passifs, privés de tout droit politique. Ce qui existait, c’était un ensemble, aux racines à la fois ethniques, culturelles et historiques, de cités dont ils étaient pleinement les citoyens, même si elles étaient liées à Sparte par une association inégalitaire qui les privait d’une part importante de leur souveraineté.
Simon le Mage et les Simoniens chez Épiphane de Salamine
Authors: Pourkier Aline 
Published: May 2021

La première hérésie chrétienne que présente Épiphane dans son Panarion est celle de Simon le Mage. Une étude attentive de cette notice montre que les traits de doctrine qu’il lui attribue sont le fait du procédé hérésiologique de l’ «assimilation » et proviennent en réalité d’hérésies gnostiques postérieures. Ces renseignements n’ont donc aucune valeur historique. Aussi faut-il se tourner vers d’autres sources (l’Apophasis
Mégalè, les Actes des Apôtres, des découvertes archéologiques en Samarie) pour trouver des informations plus fiables sur la doctrine des Simoniens et pour rectifier le portrait qu’Épiphane fait de Simon et de sa compagne Hélène.
Une histoire en détail dans le détail manquant de la fable. Les "Vénus et Adonis" de Titien au regard de la poétique ovidienne
Authors: Corneloup Anne 
Published: May 2021

Abstract–. Taking a well-known Titian poesia, Venus and Adonis, as a case study, the article investigates the definitions of the detail such as transmitted to us by the historiography of the nineties. Particolare or dettaglio,
iconic or pictural treatment, delectatio or lectio function, details meant to be seen or not, etc. : surely the image corroborates these notions (they are not purely “ theoretical”). But at the same time, it interconnects them with a joyful dexterity far ahead of our quarrels of words, in a visual discourse the dialogic density of which might be surprising – to us. Now, to what ends was such a singular logos produced by the artist ? To “ read Ovid anew”, certainly. Even better, the painter-Menocchio, weaving unexpected, potentially eloquent parallels with the others’ texts, thus brought his word to his contemporaries – he asked for their attention. For instance, on such problems as these that we would call, today, “ gender questions”.
Basileis et dynastes dans les communautés grecques et non grecques du Golfe de Tarente
Authors: Lombardo Mario 
Published: May 2021

Dans la première partie, on rappelle les problèmes soulevés par la présence de figures '' royales'' dans les poleis du Golfe de Tarente à la fin du VIe siècle : Aristophilidès, qu''Hérodote qualifie de basileus des Tarentins, et Télys, que le même historien appelle une fois basileus et une autre fois tyra nnos des Sybarites. Ces figures, et leurs pouvoirs, sont à lire dans le contexte, aristocratique auquel renvoient leurs pratiques sociales et celles de leurs amis, ou bien ennemis. 0 n discute, ensuite, les questions posées par la mention, dans les sources, de figures telles que le roi des Iapygiens Opis ou le dynaste messapien Artas, ou telles que l''anonyme dynaste
d''Oria dont le basileion, mentionné par Strabon, a récemment restitué d''importants vestiges, qui en suggèrent une datation dans les années qui suivirent l''expédition d''Alexandre le Molosse en Italie.
En torno al sistema toponímico vasco : los antrotopónimos
Authors: Salaberri Zaratiegi Patxi 
Published: May 2021

Regarding the Basque toponymic system : anthrotoponyms.
In this work we carry out an analysis of Basque anthrotoponyms, starting with the names of the Basque regions. We then mention a number of items (mostly dona, done) that are used in the formation of our hagiotoponyms. We also examine in detail the endings and suffixes found in place names with an anthroponymic basis, relating them to their corresponding Romance variants. Following this we deal with villa, a Latin or Romance common noun analogous to Basque huri, both of which frequently go together with anthroponymic bases. To conclude we draw some conclusions from the claims made in the article.
Derivati dei nomi dei mesi (<em>Marzo</em>)
Authors: Francalanci Lucia 
Published: May 2021

Continuiamo la pubblicazione della rubrica dedicata ai derivati dei nomi dei mesi con la scheda relativa marzo; chi volesse saperne di più sui derivati di gennaio e febbraio può leggere qui e qui. Per le informazioni generali si rimanda all’Introduzione.