bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing transition to care homes for people with dementia in Northern Ireland
Authors: Zafeiridi Evi , McMichael Alan J. , Passmore A. Peter , McGuinness Bernadette 
Published: March 2021

AbstractIntroductionThe increasing number of people with dementia (PwD) is a significant health and financial challenge for countries. PwD often transition to a care home. This study explored factors predicting transition to care homes for PwD and the place and causes of death.MethodsData about dementia medication, care home transitions, demographic characteristics, deaths, and hospital admissions were extracted from national databases from 2010 to 2016.ResultsPwD (n = 25,418) were identified through prescriptions of dementia medication, from which 11,930 transitioned to care homes. A logistic regression showed that increased age, female sex, living in less deprived and urban areas, and hospital admissions predicted this transition. PwD who transition to care homes are more likely to die there. The most common cause of death was dementia.DiscussionCertain demographic characteristics are significant predictors for care home transitions and they should be considered in the development of early community‐based care services to delay transitions. In the last decades, dementia has been reported more frequently in death certificates.
AdS2 duals to ADHM quivers with Wilson lines
Authors: Lozano Yolanda , Nunez Carlos , Ramirez Anayeli , Speziali Stefano 
Published: March 2021

Abstract
We discuss AdS2 × S3 × CY2 × Iρ solutions to massive Type IIA supergravity with 4 Poincaré supersymmetries. We propose explicit dual quiver quantum mechanics built out of D0 and D4 colour branes coupled to D4’ and D8 flavour branes. We propose that these quivers describe the interactions of instantons and Wilson lines in 5d gauge theories with 8 Poincaré supersymmetries. Using the RR Maxwell fluxes of the solutions, conveniently put off-shell, we construct a functional from which the holographic central charge can be derived through a geometrical extremisation principle.
Power corrections to event shapes using Eikonal dressed gluon exponentiation
Authors: Agarwal Neelima , Mukhopadhyay Ayan , Pal Sourav , Tripathi Anurag 
Published: March 2021

AbstractEvent shapes are classical tools for the determination of the strong coupling and for the study of hadronization effects in electron-positron annihilation. In the context of analytical studies, hadronization corrections take the form of power-suppressed contributions to the cross section, which can be extracted from the perturbative ambiguity of Borel-resummed distributions. We propose a simplified version of the well-established method of Dressed Gluon Exponentiation (DGE), which we call Eikonal DGE (EDGE), which determines all dominant power corrections to event shapes by means of strikingly elementary calculations. We believe our method can be generalized to hadronic event shapes and jet shapes of relevance for LHC physics.
Integrating simple genus two string invariants over moduli space
Authors: Basu Anirban 
Published: March 2021

Abstract
We consider an Sp(4, ℤ) invariant expression involving two factors of the Kawazumi-Zhang (KZ) invariant each of which is a modular graph with one link, and four derivatives on the moduli space of genus two Riemann surfaces. Manipulating it, we show that the integral over moduli space of a linear combination of a modular graph with two links and the square of the KZ invariant reduces to a boundary integral. We also consider an Sp(4, ℤ) invariant expression involving three factors of the KZ invariant and six derivatives on moduli space, from which we deduce that the integral over moduli space of a modular graph with three links reduces to a boundary integral. In both cases, the boundary term is completely determined by the KZ invariant. We show that both the integrals vanish.
Relating the b ghost and the vertex operators of the pure spinor superstring
Authors: Chandia Osvaldo , Vallilo Brenno Carlini 
Published: March 2021

Abstract
The OPE between the composite b ghost and the unintegrated vertex operator for massless states of the pure spinor superstring is computed and shown to reproduce the structure of the bosonic string result. The double pole vanishes in the Lorenz gauge and the single pole is shown to be equal to the corresponding integrated vertex operator.
RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity
Authors: Koralewska Natalia , Szczepanska Agnieszka , Ciechanowska Kinga , Wojnicka Marta , Pokornowska Maria , Milewski Marek C. , Gudanis Dorota , Baranowski Daniel , Nithin Chandran , Bujnicki Janusz M. , Gdaniec Zofia , Figlerowicz Marek , Kurzynska-Kokorniak Anna 
Published: March 2021

AbstractGuanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important regulatory roles in fundamental biological processes such as DNA replication, transcription, and translation, while aberrant G-quadruplex formation is linked to genome instability and cancer. Understanding the biological functions played by G-quadruplexes requires detailed knowledge of their protein interactome. Here, we report that both RNA and DNA G-quadruplexes are bound by human Dicer in vitro. Using in vitro binding assays, mutation studies, and computational modeling we demonstrate that G-quadruplexes can interact with the Platform–PAZ–Connector helix cassette of Dicer, the region responsible for anchoring microRNA precursors (pre-miRNAs). Consequently, we show that G-quadruplexes efficiently and stably inhibit the cleavage of pre-miRNA by Dicer. Our data highlight the potential of human Dicer for binding of G-quadruplexes and allow us to propose a G-quadruplex-driven sequestration mechanism of Dicer regulation.
Nonlocal elastodynamics and fracture
Authors: Lipton Robert P. , Jha Prashant K. 
Published: March 2021

AbstractA nonlocal field theory of peridynamic type is applied to model the brittle fracture problem. The elastic fields obtained from the nonlocal model are shown to converge in the limit of vanishing non-locality to solutions of classic plane elastodynamics associated with a running crack. We carry out our analysis for a plate subject to mode one loading. The length of the crack is prescribed a priori and is an increasing function of time.
Flug- und Schiffsverkehr während der COVID-19-Pandemie in Deutschland: Herausforderungen für den Öffentlichen Gesundheitsdienst
Authors: Kleine-Kampmann Scarlett , Schöll Meike , Ehlers Lena , Hewelt Elisabeth , Götsch Udo , Göbels Klaus , Ippisch Siegfried , Seidel Juliane , Thanheiser Marc , Schindler Bert , Kalkowski Mathias , Boldt Matthias , Dirksen-Fischer Martin , von Münster Thomas , Jeglitza Matthias , Chmielewska Justyna , Sangs André , Mouchtouri Barbara , Rexroth Ute , an der Heiden Maria 
Published: March 2021

ZusammenfassungCOVID-19 stellt unsere Gesellschaft seit Januar 2020 vor große Herausforderungen. Durch den globalen Reiseverkehr konnte sich das neue Coronavirus rasch weltweit ausbreiten. In diesem Artikel sollen übersichtsartig die Herausforderungen bei der Implementierung von Maßnahmen im Flug- und Schiffsverkehr aus Sicht des Öffentlichen Gesundheitsdienstes (ÖGD) dargestellt werden. Dies erfolgt anhand einer Auswahl von Ereignissen und Maßnahmen zwischen Januar und August 2020. Die gewonnenen Erkenntnisse werden diskutiert.Während der COVID-19-Pandemie bewegt sich der ÖGD in einem Spannungsfeld, das sich aus der Dynamik wissenschaftlicher Erkenntnisse, politischer Entscheidungen und der Akzeptanz und Zustimmung in der Gesellschaft ergibt. An Grenzübergangsstellen wie Flug- und Seehäfen gibt es besondere Herausforderungen. Dazu gehören insbesondere Personalengpässe und die Notwendigkeit, Maßnahmen mit hohem organisatorischen Aufwand sehr kurzfristig umzusetzen, wie etwa gesundheitsbehördliche Passagierkontrollen direkt an Luftfahrzeugen, die Einrichtung von Testzentren an Grenzübergangsstellen sowie die Überprüfung der Einhaltung von Quarantänevorgaben. Erschwerend kommt hinzu, dass Passagierlisten, die zur effektiven Kontaktpersonennachverfolgung notwendig sind, oft fehlen oder unvollständig sind. Ebenso fehlen digitale Tools für das Kontaktpersonenmanagement, aber z. B. auch für den Austausch personenbezogener Daten innerhalb des ÖGD. Weitere Schwierigkeiten beim Ausbruchsmanagement ergeben sich durch die engen Verhältnisse an Bord von Schiffen und durch die mögliche psychische Belastung von Besatzung und Passagieren, die in den Maßnahmen noch nicht ausreichend berücksichtigt werden.Angesichts all dieser Herausforderungen ist es notwendig, den ÖGD langfristig zu stärken – allgemein und an den Grenzübergangsstellen – und den Bund-Länder-Austausch im Flug- und Schiffsverkehr zu intensivieren.
Dizziness Handicap Inventory in der Qualitätssicherung der Therapie vestibulärer Funktionsstörung
Authors: Duong Dinh T. A. , Wittenborn J. , Westhofen M. 
Published: March 2021

ZusammenfassungDie Therapie peripherer vestibulärer Funktionsstörungen stellt eine Herausforderung für viele HNO-Ärzte dar. Diese besteht nicht nur in der Durchführung der differenzierten neurootologischen Diagnostik, sondern auch in der Therapie und in der Verlaufskontrolle von Patienten mit vestibulärer Funktionsstörung. Insbesondere die Qualitätssicherung solcher Therapie wird in der Regel nicht adäquat abgebildet und dokumentiert. Die deutsche, validierte Version des Dizziness Handicap Inventory (DHI) bietet eine praktikable Möglichkeit zur Evaluierung und Verlaufskontrolle der Therapieergebnisse. In einer Studie wurden die Beschwerden von Patienten, welche in der HNO-Klinik des Universitätsklinikums Aachen aufgrund einer unilateralen peripheren vestibulären Funktionsstörung behandelt wurden, prä- bzw. posttherapeutisch mittels DHI erfasst und ausgewertet. Die posttherapeutische Erhebung des DHI-Scores erfolgte telefonisch. Die Auswertung der erhobenen DHI-Scores ergab in 92 % der Fälle eine signifikante Reduzierung der Schwindelbeschwerden. Es bestätigte sich die Eignung des DHI als Instrument zur Qualitätssicherung für die Funktionsdiagnostik und die darauf folgende Therapie von vestibulären Funktionsstörungen.
CM values of higher automorphic Green functions for orthogonal groups
Authors: Bruinier Jan Hendrik , Ehlen Stephan , Yang Tonghai 
Published: March 2021

AbstractGross and Zagier conjectured that the CM values (of certain Hecke translates) of the automorphic Green function $$G_s(z_1,z_2)$$

G
s

(

z
1

,

z
2

)

for the elliptic modular group at positive integral spectral parameter s are given by logarithms of algebraic numbers in suitable class fields. We prove a partial average version of this conjecture, where we sum in the first variable $$z_1$$

z
1

over all CM points of a fixed discriminant $$d_1$$

d
1

(twisted by a genus character), and allow in the second variable the evaluation at individual CM points of discriminant $$d_2$$

d
2

. This result is deduced from more general statements for automorphic Green functions on Shimura varieties associated with the group $${\text {GSpin}}(n,2)$$

GSpin
(
n
,
2
)

. We also use our approach to prove a Gross–Kohnen–Zagier theorem for higher Heegner divisors on Kuga–Sato varieties over modular curves.
Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation
Authors: Vallet Mahéva , Sophocleous Antonia , Törnqvist Anna E. , Azfer Asim , Hof Rob van’t , Albagha Omar ME , Ralston Stuart H. 
Published: March 2021

AbstractCommon genetic variants at the RIN3 locus on chromosome 14q32 predispose to Paget’s disease of bone (PDB) but the mechanisms by which they do so are unknown. Here, we analysed the skeletal phenotype of female mice with targeted inactivation of the mouse Rin3 gene (Rin3−/−) as compared with wild-type littermates. The Rin3−/− mice had higher trabecular bone volume (BV/TV%) compared with wild type. Mean ± standard deviation values at the distal femur at 8 weeks were 9.0 ± 2.5 vs. 7.0 ± 1.5 (p = 0.002) and at 52 weeks were 15.8 ± 9.5 vs. 8.5 ± 4.2 (p = 0.002). No differences were observed in femoral cortical bone parameters with the exception of marrow diameter which was significantly smaller in 52-week-old Rin3−/− mice compared to wild type: (0.43 mm ± 0.1 vs. 0.57 mm ± 0.2 (p = 0.001). Bone histomorphometry showed a lower osteoclast surface / bone surface (Oc.S/BS%) at 8 weeks in Rin3−/− mice compared to wild type (24.1 ± 4.7 vs. 29.7 ± 6.6; p = 0.025) but there were no significant differences in markers of bone formation at this time. At 52 weeks, Oc.S/BS did not differ between genotypes but single labelled perimeter (SL.Pm/B.Pm (%)) was significantly higher in Rin3−/− mice (24.4 ± 6.4 vs. 16.5 ± 3.8, p = 0.003). We conclude that Rin3 negatively regulates trabecular bone mass in mice by inhibiting osteoclastic bone resorption and favouring bone formation. Our observations also suggest that the variants that predispose to PDB in humans probably do so by causing a gain-in-function of RIN3.
Two homologs of the Cat8 transcription factor are involved in the regulation of ethanol utilization in Komagataella phaffii
Authors: Barbay Diane , Mačáková Monika , Sützl Leander , De Sonakshi , Mattanovich Diethard , Gasser Brigitte 
Published: March 2021

AbstractThe transcription factors Cat8 and Sip4 were described in Saccharomyces cerevisiae and Kluyveromyces lactis to have very similar DNA binding domains and to be necessary for derepression of a variety of genes under non-fermentative growth conditions via binding to the carbon source responsive elements (CSREs). The methylotrophic yeast Komagataella phaffii (syn Pichia pastoris) has two transcription factors (TFs), which are putative homologs of Cat8 based on sequence similarity, termed Cat8-1 and Cat8-2. It is yet unclear in which cellular processes they are involved and if one of them is actually the homolog of Sip4. To study the roles of the Cat8 homologs in K. phaffii, overexpression or deletion strains were generated for the two TFs. The ability of these mutant strains to grow on different carbon sources was tested, and transcript levels of selected genes from the carbon metabolism were quantified. Our experiments showed that the TFs are required for the growth of K. phaffii on C2 carbon sources, but not on glucose, glycerol or methanol. K. phaffii deleted for Cat8-1 showed impaired growth on acetate, while both Cat8-1 and Cat8-2 are involved in the growth of K. phaffii on ethanol. Correspondingly, both TFs are participating in the activation of ADH2, ALD4 and ACS1, three genes encoding enzymes important for the assimilation of ethanol. Different from S. cerevisiae and K. lactis, Cat8-1 is not regulating the transcription of the putative Sip4-family member Cat8-2 in K. phaffii. Furthermore, Cat8-1 is necessary for the activation of genes from the glyoxylate cycle, whereas Cat8-2 is necessary for the activation of genes from the carnitine shuttle. Neither Cat8-1 nor Cat8-2 are required for the activation of gluconeogenesis genes. Finally, the CAT8-2 gene is repressed by the Mig1-2 transcription factor on glucose and autorepressed by the Cat8-2 protein on all tested carbon sources. Our study identified the involvement of K. phaffii Cat8-1 and Cat8-2 in C2-metabolism, and highlighted similarities and differences to their homologs in other yeast species.
Radiomics score predicts acute respiratory distress syndrome based on the initial CT scan after trauma
Authors: Röhrich Sebastian , Hofmanninger Johannes , Negrin Lukas , Langs Georg , Prosch Helmut 
Published: March 2021

Abstract
Objectives
Acute respiratory distress syndrome (ARDS) constitutes a major factor determining the clinical outcome in polytraumatized patients. Early prediction of ARDS is crucial for timely supportive therapy to reduce morbidity and mortality. The objective of this study was to develop and test a machine learning–based method for the early prediction of ARDS derived from the first computed tomography scan of polytraumatized patients after admission to the hospital.

Materials and methods
One hundred twenty-three patients (86 male and 37 female, age 41.2 ± 16.4) with an injury severity score (ISS) of 16 or higher (31.9 ± 10.9) were prospectively included and received a CT scan within 1 h after the accident. The lungs, including air pockets and pleural effusions, were automatically segmented using a deep learning–based algorithm. Subsequently, we extracted radiomics features from within the lung and trained an ensemble of gradient boosted trees (GBT) to predict future ARDS.

Results
Cross-validated ARDS prediction resulted in an area under the curve (AUC) of 0.79 for the radiomics score compared to 0.66 for ISS, and 0.68 for the abbreviated injury score of the thorax (AIS-thorax). Prediction using the radiomics score yielded an f1-score of 0.70 compared to 0.53 for ISS and 0.57 for AIS-thorax. The radiomics score achieved a sensitivity and specificity of 0.80 and 0.76.

Conclusions
This study proposes a radiomics-based algorithm for the prediction of ARDS in polytraumatized patients at the time of admission to hospital with an accuracy that competes and surpasses conventional scores despite the heterogeneous, and therefore more realistic, scanning protocols.

Key Points
• Early prediction of acute respiratory distress syndrome in polytraumatized patients is possible, even when using heterogenous data.
• Radiomics-based prediction resulted in an area under the curve of 0.79 compared to 0.66 for the injury severity score, and 0.68 for the abbreviated injury score of the thorax.
• Highlighting the most relevant lung regions for prediction facilitates the understanding of machine learning–based prediction.
Glaukomversorgung in Deutschland – Ergebnisse einer Mitgliederumfrage von DOG und BVA – Teil 1: Diagnostik
Authors: Wolfram Christian , Schuster Alexander K. 
Published: March 2021

Zusammenfassung
Hintergrund
Die Möglichkeiten in der Glaukomversorgung sind in den letzten Jahren immer vielfältiger geworden. Unter den Mitgliedern der Deutschen Ophthalmologischen Gesellschaft (DOG) und des Berufsverbands der Augenärzte Deutschlands (BVA) wurde eine anonymisierte Befragung durchgeführt, um zu erfassen, welche Behandlungswege in der Versorgung von Glaukompatienten gewählt werden, welche diagnostischen Parameter den Augenärztinnen und Augenärzten wichtig sind und welche Rolle Behandlungsleitlinien in der Alltagspraxis zukommt.

Ziel der Arbeit
Meinungsbild unter der deutschen Augenärzteschaft über die aktuelle Glaukomversorgung, zentrale diagnostische Parameter und ihre Anwendung in der Alltagspraxis.

Material und Methoden
Die Befragung wurde durch einen Online-Fragebogen mit insgesamt 26 Fragen (107 Items) zur Versorgungspraxis in der Glaukomdiagnostik und der Glaukomtherapie durchgeführt. Vollständig ausgefüllte Fragebögen lagen von 1361 Personen vor.

Ergebnisse
Die Papillenbeurteilung an der Spaltlampe hat für Augenärzte weiterhin den höchsten diagnostischen Stellenwert. Auch der Rolle der optischen Kohärenztomographie (OCT) kommt eine sehr hohe diagnostische Bewertung zu. Bei der Interpretation verschiedener diagnostischer Parameter ergibt sich eine höhere Sicherheit für papillennahe Parameter unter den Befragten. Eine leitliniengemäße Versorgung wird nach Selbstauskunft der Augenärzte weitgehend betrieben. Etwa zwei Drittel der Befragten führen im ersten Behandlungsjahr zwei oder mehr Gesichtsfelduntersuchungen durch und ebenso eine strukturelle Papillendarstellung einmal im Jahr. Die Rolle der Gonioskopie wird kontrovers gesehen und nicht einheitlich intensiv praktiziert.

Diskussion
Die Diagnosestellung beim Glaukom ist eine große klinische Herausforderung. Die verschiedenen diagnostischen Parameter haben einen unterschiedlich hohen Wert für Augenärzte. Morphometrische Verfahren haben eine sehr hohe Bedeutung gewonnen und ermöglichen eine assistierte, jedoch keine automatisierte Diagnostik. Mehr Behandlungsleitlinien und Standards bei der Glaukomversorgung werden gewünscht und sollten in Aus- und Weiterbildung und in den Behandlungsalltag implementiert sein.
Role of legs and foot adhesion in salticid spiders jumping from smooth surfaces
Authors: Goetzke Hanns Hagen , Federle Walter 
Published: March 2021

AbstractMany spiders and insects can perform rapid jumps from smooth plant surfaces. Here, we investigate how jumping spiders (Pseudeuophrys lanigeraandSitticus pubescens) avoid slipping when accelerating. Both species differed in the relative contribution of leg pairs to the jump.P. lanigeraaccelerated mainly with their long third legs, whereas their short fourth legs detached earlier. In contrast,S. pubescensaccelerated mainly with their long fourth legs, and their short third legs detached earlier. Because of the different orientation (fourth-leg tip pointing backward, third-leg tip pointing forward), the fourth-leg tarsus pushed, whereas the third-leg tarsus pulled. High-speed video recordings showed that pushing and pulling was achieved by different attachment structures. InP. lanigera, third-leg feet made surface contact with setae on their distal or lateral claw tuft, whereas fourth-leg feet engaged the proximal claw tuft, and the distal tuft was raised off the ground.S. pubescensshowed the same division of labour between proximal and distal claw tuft for pushing and pulling, but the claw tuft contact lasted longer and was more visible in the fourth than in the third legs. Experimental ablation of claw tufts caused accelerating spiders to slip, confirming that adhesion is essential for jumps from smooth substrates.
Defunctioning stoma and short- and long-term outcomes after low anterior resection for rectal cancer—a nationwide register–based cohort study
Authors: Gadan Soran , Brand Judith S. , Rutegård Martin , Matthiessen Peter 
Published: March 2021

Abstract
Purpose
A defunctioning stoma reduces the risk of symptomatic anastomotic leakage after low anterior resection for rectal cancer and mitigates the consequences when a leakage occurs, but the impact on mortality and oncological outcomes is unclear. The aim was to investigate the associations of a defunctioning stoma with short- and long-term outcomes in patients undergoing low anterior resection for rectal cancer.

Methods
Data from all patients who underwent curative low anterior resection for rectal cancer between 1995 and 2010 were obtained from the Swedish Colorectal Cancer Register. A total of 4130 patients, including 2563 with and 1567 without a defunctioning stoma, were studied. Flexible parametric models were used to estimate hazard ratios for all-cause mortality, 5-year local recurrence, and distant metastatic disease in relation to the use of defunctioning stoma, adjusting for confounding factors and accounting for potential time-dependent effects.

Results
During a median follow-up of 8.3 years, a total of 2169 patients died. In multivariable analysis, a relative reduction in mortality was observed up to 6 months after surgery (hazard ratio = 0.82: 95% CI 0.67–0.99), but not thereafter. After 5 years of follow-up, 4.2% (173/4130) of the patients had a local recurrence registered and 17.9% (741/4130) had developed distant metastatic disease, without difference between patients with and without defunctioning stoma.

Conclusion
A defunctioning stoma is associated with a short-term reduction in all-cause mortality in patients undergoing low anterior resection for rectal cancer without any difference in long-term mortality and oncological outcomes, and should be considered as standard of care.