bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staff perceptions of the implementation of a trauma video review program at a level I trauma center
Authors: Dainty Katie N. , Seaton M. Bianca , McGowan Melissa , Nolan Brodie 
Published: December 2021

AbstractObjectivesSuccessful implementation of any new technology requires extensive engagement with front‐line staff. We explored the perceptions of emergency department and trauma staff about a trauma video review program (TVR) prior to implementation of the first such program in Canada at our level I trauma center.MethodsWe conducted semi‐structured individual interviews and in situ small group interviews with 35 multidisciplinary ED and trauma staff members of a teaching and research hospital in Toronto, Canada. We sought maximum variation in the sample of purposively selected participants. Interviews were recorded with audiotapes or detailed field notes, transcribed verbatim, coded, and analyzed using standard thematic analysis techniques.ResultsParticipants expressed overall support for the concept of TVR, but there is a core sense of unease that influenced overall staff perceptions. Despite several departmental presentations, very few participants actually had a solid understanding of how the TVR worked. Many were apprehensive about their own professional privacy, deeply concerned about vulnerable patients being filmed without consent, and questioned how video data would be used. Despite significant hesitancy, ED and trauma staff identified positive opportunities that TVR could bring, including providing an evidence base for quality improvement.ConclusionsTVR is an evolving approach to evaluate quality and patient safety in the trauma bay. As such it brings with it natural concerns and apprehension from staff regarding privacy, confidentiality, and how data will be captured and used. There is opportunity for these types of concerns to be addressed with a robust knowledge translation plan and engagement of staff throughout the implementation process.
Reconstructing the Past, Renegotiating Authority: Reconstructed Archaeological Sites in Present‐Day Poland
Authors: Pawleta Michał 
Published: December 2021

AbstractThe aim of this paper is to examine open‐air, full‐scale archaeological reconstructions through the prism of concepts of authority and truth. I will approach it along the lines of a praxeology of truth. Accordingly, the questions asked here mainly address negotiations of truth and the practical context in which truth claims are embedded, as well as broader implications accompanying the invocation, questioning, perversion, and deconstruction of truth. Selected examples from Poland are cited, embodying issues of the creation and negotiation of truth claims about the past and illustrating how the authority of archaeologists and other professional heritage specialists sometimes clashes with broader processes and various heritage stakeholders.
LINC00473‐modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid‐induced osteonecrosis of femoral head: A detailed mechanistic study and validity evaluation
Authors: Xu Yingxing , Jiang Yaping , Wang Yingzhen , Jia Bin , Gao Song , Yu Haiyang , Zhang Haining , Lv Chengyu , Li Haiyan , Li Tao 
Published: December 2021

AbstractThe pathogenesis of steroid‐induced osteonecrosis of the femoral head (SONFH) involves a glucocorticoid‐induced imbalance of osteogenic and adipogenic differentiation, and apoptosis of bone marrow mesenchymal stem cells (BMSCs). An increasing number of genes, especially noncoding RNAs, have been implicated in the function of BMSCs. Our previous studies have confirmed the key role of LINC00473 and miR‐23a‐3p on the osteogenic, adipogenic differentiation, and apoptosis of BMSCs. However, the underlying mechanism of this process is still unclear. Based on bioinformatics analysis, here we investigated the effects of LINC00473 on the LRP5/Wnt/β‐catenin signaling pathway in the osteogenesis and adipogenesis of BMSCs, as well as the PEBP1/Akt/Bad/Bcl‐2 signaling pathway in dexamethasone‐ (Dex‐) induced apoptosis of BMSCs. Our data showed that LINC00473 could promote osteogenesis and suppress the adipogenesis of BMSCs through the activation of the miR‐23a‐3p/LRP5/Wnt/β‐catenin signaling pathway axis, while rescuing BMSCs from Dex‐induced apoptosis by activating the miR‐23a‐3p/PEBP1/Akt/Bad/Bcl‐2 signaling pathway axis. Notably, we observed that LINC00473 interacted with miR‐23a‐3p in an Argonaute 2 (AGO2)‐dependent manner based on dual‐luciferase reporter assay, AGO2‐related RNA immunoprecipitation, and RNA antisense purification assay. Furthermore, injectable thermosensitive polylactic‐co‐glycolic acid (PLGA) hydrogel loaded with rat‐derived BMSCs (rBMSCs) modified by LINC00473 were used for the treatment of SONFH in a rat model. Our results demonstrated that PLGA hydrogels provided a suitable environment for harboring rBMSCs. Besides, transplantation of PLGA hydrogels loaded with rBMSCs modified by LINC00473 could significantly promote the bone repair and reconstruction of the necrotic area at the femoral head in our SONFH rat model. Surprisingly, compared with the transplantation of BMSCs alone, the transplanted rBMSCs encapsulated within the PLGA hydrogel could migrate from the medullary cavity to the femoral head. In summary, LINC00473 promoted osteogenesis, inhibited adipogenesis, and antagonized Dex‐induced apoptosis of BMSCs. Therefore, LINC00473 could provide a new strategy for the treatment of SONFH.
Cancer registry study of malignant hepatic vascular tumors: hepatic angiosarcomas and hepatic epithelioid hemangioendotheliomas
Authors: Martínez Constanza , Lai Jonathan K. , Ramai Daryl , Facciorusso Antonio , Gao Zu‐Hua 
Published: December 2021

AbstractBackgroundMalignant vascular tumors (MVTs) are rare and often misdiagnosed due to wide range of clinical presentations, varied histology, and exquisite imagining features. We aim to characterize two different types of MVTs of the liver: hepatic angiosarcomas (HA) and hepatic epithelioid hemangioendotheliomas (HEHE).MethodsData on HA and HEHE between 1975 and 2016 were extracted from the SEER database and analyzed.ResultsA total of 366 patients with HA were identified where 64.2% were male and 79% of White race. The median age at diagnosis was 64 ± 16.2 years. Distant metastasis was found in 24% of patients, regional disease in 22.1%, and localized disease in 21.3%. The median overall survival for HA was 2 months. For HEHE, 120 cases were identified, 32.5% were male and 80% of White race. The median age of diagnosis was 51 ± 16.8 years. Distant metastasis was found in 37.5% of patients, regional disease in 27.5%, and localized disease in 20%. The median overall survival was 182 months.ConclusionPatients’ demographics such as race, age, and gender may assist in elucidating distinct subtypes of MVTs. HA is an aggressive tumor despite intervention. Patients with HEHE tumors have significantly better survival compared to patients with HA. Further studies are needed to deepen our knowledge about the histopathology of these tumors, the outcomes of liver transplantation as a therapeutic alternative, and available molecular targets for MVTs.
The assemblage of inter‐ethnic marriages in Indonesia
Authors: Yulianto Jony Eko , Hodgetts Darrin , King Pita , Liu James H. 
Published: December 2021

AbstractInter‐ethnic married couples develop their intimate lives together within the context of their broader cultural communities. Drawing from 10‐weeks of fieldwork with ten Javanese and Chinese Indonesian couples (65 interviews, over 500 pages of transcript, 70 pages of field notes, and over 360 photographs), we approach such marriages as dynamic sites of cultural hybridity and the re‐assemblage of key elements from the participants' ethno‐cultural assemblages of origin. We document how mundane social practices, such as practicing respect for elders, observing religious practices, combining familial work traditions and fusion cooking are instrumental elements in establishing culturally‐hybrid ways of conducting more harmonious lives together. The conceptual framework developed for this article from the assemblage and social practice theories offers a novel approach to exploring everyday cultural hybridity in the conduct nature of inter‐ethnic marriages.
Comparative Evaluation of Antioxidant and Anti‐Inflammatory Activity of Active Compounds Identified in Ardisia elliptica Extracts from Different Plant Parts
Authors: Buraphaka Hathairat , Puttha Watthika , Putalun Waraporn 
Published: December 2021

AbstractArdisia elliptica Thunb. (AE) has been used as food and in traditional medicine to prevent and treat fever, diarrhea, chest pain, liver poisoning, and parturition complications in Southeast Asian countries. This study focused on phytochemical constituents of AE extracts and their antioxidant and anti‐inflammatory activity in vitro by evaluating nitric oxide production, and DPPH and FRAP radical scavenging activity. The bioactive compounds from different plant parts, including old leaves, young leaves, flowers, roots, and fruits, were identified. The results showed the highest phenolic and flavonoid content in the root extract among all extracts, which resulted in the most potent free radical scavenging activity revealed by the DPPH and FRAP assay. The roots and flowers showed the highest bergenin (3.36±0.22 mg/g dry weight) and quercetin (2.99±0.10 mg/g dry weight) content, respectively. In contrast, embelin was found only in the fruits. Interestingly, AE extracts significantly suppressed the mRNA expression of inducible nitric oxide synthase, leading to inhibition of nitric oxide production in lipopolysaccharide‐stimulated RAW 264.7 macrophages. Conclusively, the results suggest the natural products of AE extracts as effective antioxidant and anti‐inflammatory agents that can be utilized for food and pharmaceutical applications.
Assessment of clinical mental health counseling competencies for preparation programs
Authors: Lambie Glenn W. , Haugen Jaimie Stickl 
Published: December 2021

AbstractThe evaluation of clinical mental health counseling competencies is essential for preparation programs. Therefore, our article (a) reviews the developmental nature of counselors‐in‐training, (b) presents the importance of quality evaluation measures, (c) introduces the Assessment of Clinical Mental Health Counseling Competencies, and (d) offers implications for research and practice.
PROTOCOL: Residential energy efficiency interventions: An effectiveness systematic review
Authors: Berretta Miriam , Furgeson Joshua , Zamawe Collins , Hamilton Ian , Wu Yue , Ferraro Paul J. , Haddaway Neal , Eyers John 
Published: December 2021

AbstractThis review aims to identify, appraise and synthesise the evidence available on the effectiveness of energy efficiency measure installations, including those bundled with behavioural interventions. The synthesis will estimate the overall impact of these interventions as well as examine possible causes of variation in impacts. We will also attempt to assess the cost‐effectiveness of residential energy efficiency interventions.
A massively parallel speciation‐based differential evolution algorithm applied to the 3D‐AB protein structure prediction
Authors: Stubs Parpinelli Rafael , Boiani Mateus , Dias André E. P. 
Published: December 2021

AbstractOne of the most challenging problems in Bioinformatics is the finding of a protein conformation and it is known as the Protein Structure Prediction (PSP) problem. The main feature present in the AB off‐lattice model is the use of polarity as the main driving force to guide the optimization process. The present work proposes an adaptive evolutionary algorithm based on GPU that is applied to the 3D‐AB off‐lattice PSP problem. The proposed approach is named cuDSMjDE, and is composed of a Dynamic Speciation‐based Mutation Strategies Differential Evolution that employs the jDE mechanism to control F and CR parameters. A crowding strategy is also adopted, increasing competition between individuals and maintaining the diversity of solutions. All routines of the proposed algorithm are developed to run in GPU. During the experiments, eight Protein Data Bank sequences are employed. Results obtained concerning potential energy are competitive when compared with state‐of‐the‐art algorithms. The use of a massively parallel architecture promoted the necessary scalability with speedups up to 708.78.
Volatile Compounds from Flowers of Elaeagnus x submacrophylla Servett.: Extraction, Identification of Flavonoids, and Antioxidant Capacity
Authors: Parrot Isabelle , Bisi Hélène , Folliard Arnaud , Bonnard Michel 
Published: December 2021

AbstractBeneficial to the ecosystem and with significant potential in permaculture, Elaeagnus x submacrophylla Servett. was studied here mainly for the identification of its floral odorants. After olfactory evaluation and determination of the volatile profile of freshly picked flowers by headspace/solid phase microextraction coupled with gas chromatography/mass spectrometry, an ethanolic extract was prepared and investigated for its antioxidant capacity. Unusual molecules were identified in the floral headspace, such as isochavicol or chrysanthemum acetate. The evaluation of the in vitro free radical scavenging capacity (from 0.4 to 1.3 mmol TE/g) and total phenolic content (65.1 mg GAE/g) of the extract pointed out a promising antioxidant activity, potentially related to the identification of several flavonoid glycosides. These results have to be considered in the context of the ever‐increasing need to produce innovative natural extracts with notably interesting claims for the cosmetic field.
Do cold weather temperatures affect the efficacy of skin decontamination?
Authors: Thors Lina , Wästerby Pär , Wigenstam Elisabeth , Larsson Andreas , Öberg Linda , Bucht Anders 
Published: December 2021

AbstractSkin decontamination in cold weather temperatures might be challenging due to the aggravating circumstances. However, no information is available on the efficacy of commonly used procedures in winter conditions. Therefore, the efficacy of the reactive skin decontamination lotion (RSDL) and soapy water decontamination following skin exposure to the nerve agent VX was evaluated at three ambient air temperatures (−5°C, −15°C and room temperature). Experiments were performed in vitro using human dermatomed skin. The ability of RSDL to degrade VX at the three different air temperatures was separately evaluated. The ambient air temperature in experiments without decontamination did not influence the penetration rate of VX through skin. RSDL decontamination was highly efficient in removing VX from skin when performed in all three ambient temperatures, despite the slower agent degradation rate of VX at the lower temperatures. Decontamination with soapy water at RT resulted in an increased skin penetration of VX compared with the control without decontamination; however, in colder temperatures the VX skin penetration was similar to the corresponding control without decontamination. At RT, dry removal prior to washing with soapy water did not improve decontamination of VX compared with washing solely with soapy water. This study demonstrated high efficacy of RSDL decontamination following skin exposure to VX also at cold temperatures. The previously reported ‘wash‐in’ effect of soapy water on VX skin penetration was reduced at cold temperatures. Altogether, this study found a scientific basis to establish guidelines for skin decontamination of chemical casualties at cold weather temperatures.
Carbazole‐based dual‐functional chemosensor: Colorimetric sensor for Co2+ and fluorescent sensor for Cu2+ and its application
Authors: Liu Li , Liu Xiaonan , Guo Changqing , Fang Min , Li Cun , Zhu Weiju 
Published: December 2021

AbstractA new carbazole derivative CNS was prepared by the condensation of 2‐hydrazine benzothiazole with 3‐aldehyde‐6‐naphthalene‐N‐butyl carbazole, which could highly selectively discriminate Co2+ and Cu2+ in different solvent systems. CNS could enable the recognition of Co2+ by the “naked eye,” with the color changing from colorless to pale yellow in DMSO/H2O (v/v = 1:1). The addition of Cu2+ made the fluorescence emission intensity increase nearly 10 times, which was accompanied by a weak blue shift of the emission peak in CH3CN. Under the illumination of 365 nm ultraviolet lamp, the color of the CNS solution changed from light blue to dark blue after Cu2+ was added. The binding process could be reasonably speculated by spectrometric titrations, 1H NMR, mass spectrometry (MS) analysis, and density functional theory (DFT) calculation. The results of fluorescence electron microscopy showed that CNS could be used as a fluorescent sensor to detect Cu2+ in Hela cells. In addition, CNS was successfully used for the detection of Cu2+ in actual water samples.
Enhanced aquathermolysis of heavy oil catalysed by bentonite supportedFe(III)complex in the present of ethanol
Authors: Ma Liwa , Zhang Shu , Zhang Xiaolong , Dong Sanbao , Yu Tao , Slaný Michal , Chen Gang 
Published: December 2021

AbstractBACKGROUNDPrevious research on the aquathermolysis of heavy oil has ignored the relationship between exogenous catalysts andin‐situinorganic minerals when the reaction temperature is high.RESULTSA series of bentonite‐supported transition metal complexes was synthesized and used in the aquathermolysis of heavy oil; among them, B@Fe(III)L was the most effective one. Under optimal conditions, 0.5% catalyst and 10% ethanol reacted at 250 °С for 4 h can reduce the viscosity of heavy oil by 84.5%. elemental analysis (EL), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), group composition, and analysis show that the catalyst enhances the destruction process of resin and asphaltene, promotes the more complete cracking reaction of most macromolecular components, and increases the proportion of light fraction of heavy oil. Gas chromatography–mass spectrometry (GC–MS) analysis also indicated that B@Fe(III)L can help to decrease the polar substances in heavy oil and reduce the aromaticity of polar substances.CONCLUSIONThe B@Fe(III)L prepared can enhance the destruction process of resin and asphaltene, promote the more complete cracking reaction of most macromolecular components, and increase the proportion of light fraction of heavy oil, thereby reducing the viscosity of heavy oil. Therefore, B@Fe(III)L can achieve efficientin‐situviscosity reduction, and this work promotes related research and applications in this field. © 2021 Society of Chemical Industry (SCI).
(±)‐cis‐4a‐alkyl‐1,3,4,4a,9,9a‐hexahydro‐2H‐carbazol‐2‐ones by domino nitro reduction‐aza‐Michael addition to enones
Authors: Embrey Samuel J. , Barrios‐Perez Carlos , Bunce Richard A. 
Published: December 2021

AbstractA domino nitro reduction‐aza‐Michael addition sequence has been investigated for α,β‐unsaturated ketones and compared with the analogous reaction for conjugated esters. As expected, six‐membered ring closures of ketones did not proceed as well as for esters (<60% vs. >85%) due to the greater inherent reactivity of the ketones. This problem was minimized by performing the cyclization at lower temperature for a shorter time. The process has been extended to a synthesis of (±)‐cis‐4a‐alkyl‐1,3,4,4a,9,9a‐hexahydro‐2H‐carbazol‐2‐ones with good yields (65%–86%). While the rigidity of the system and closure of the smaller five‐membered ring created some strain in the products, yields were acceptable. The cis ring junction resulted from axial attack to give a more stable chair‐like enol that tautomerized to the target heterocycle.
Spectroscopic studies, quantum chemical investigations, and in silico and in vitro scrutiny of the diuretic drug trichlormethiazide adsorbed onAuNPs
Authors: Shyni V. , Leenaraj D. R. , Ittyachan Reena , Shyju G. J. , Joseph Lynnette , Sajan D. 
Published: December 2021

AbstractExperimental and theoretical study was employed to study the adsorption of the diuretic drug, trichlormethiazide (TCM) molecule on AuNPs (TCMA). The stereoelectronic properties of the molecular structure of most stable conformers of TCM and TCMA were studied using DFT/B3LYP‐6‐311++G (d, p) together with LANL2DZ methodology. The Fourier transform Raman and Infrared spectra of TCM were recorded and analyzed. Quantum chemical calculations of TCM and TCMA molecules were used to evaluate the stability of the molecule, hyper‐conjugative interactions, electron delocalization, and binding interactions. The calculated and experimentally observed vibrational frequencies of the molecule were assigned and compared. The shifting and intensity enhancement of the CCl2band manifests the back‐donation and conjugation effect, which are the result of the presence of nitrogen atom adjoining the dichloromethyl groups and the oxygen in the sulfur dioxide group attached among the amino group and the chlorophenyl ring, respectively, which enhances bioactivity. Anticancer activity was examined based on molecular docking analysis, and it was identified that TCM and TCMA molecules act as good inhibitors against lung cancer. SERS analysis and MTT assay confirmed the molecular docking analysis results.
A new optimal model predictive control scheme for a wind energy conversion system
Authors: Pradhan Prangya Parimita , Subudhi Bidyadhar , Ghosh Arnab 
Published: December 2021

AbstractThe correct management of power exchange between the doubly‐Fed induction generator (DFIG) and the grid depends on the effective optimal operation of the DFIG based wind energy conversion system (WECS). A modified optimal model predictive controller (MPC) architecture for WECS is proposed in this paper. The proposed scheme is carried out in two stages, as follows: (a) Using the MPC model and the tracking factor, an optimal control law is created, and (b) the aforementioned optimized issue is addressed using the linear matrix inequality (LMI) approach. Some improvements were made to the conventional LMI‐based MPC technique to lower the high computational complexity. To perform active and reactive power control in DFIG, the proposed approach is applied on the rotor‐side converter (RSC) control. The control law is divided into two sections. The first section deals with rotor current, while the second section deals with the RSC switching states. The LMI is used in the second portion of the control law to find the best switching state solution. The proposed method was created using the MATLAB/SIMULINK environment and tested in a 1hP DFIG‐WECS setup. By comparing the obtained results to conventional LMI‐PI, MPC‐based WECS, the effectiveness of the obtained results is verified. Variable wind speed conditions are used to vary all the results. Integral absolute error, integral time absolute error, and Integral square error measurements are used to compare the tracking performance index of all methods.