bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Second Discovery from the COCONUTS Program: A Cold Wide-orbit Exoplanet around a Young Field M Dwarf at 10.9 pc
Authors: Zhang 张 Zhoujian 周 健 , Liu Michael C. , Claytor Zachary R. , Best William M. J. , Dupuy Trent J. , Siverd Robert J. 
Published: July 2021

Abstract
We present the identification of the second discovery from the COol Companions ON Ultrawide orbiTS (COCONUTS) program, the COCONUTS-2 system, composed of the M3 dwarf L 34-26 and the T9 dwarf WISEPA J075108.79−763449.6. Given their common proper motions and parallaxes, these two field objects constitute a physically bound pair with a projected separation of 594″ (6471au). The primary star COCONUTS-2A has strong stellar activity (Hα, X-ray, and ultraviolet emission) and is rapidly rotating (Prot = 2.83 days), from which we estimate an age of 150–800 Myr. Comparing equatorial rotational velocity derived from the Transiting Exoplanet Survey Satellite (TESS) light curve to spectroscopic vsini, we find that COCONUTS-2A has a nearly edge-on inclination. The wide exoplanet COCONUTS-2b has an effective temperature of T
eff = 434 ± 9 K, a surface gravity of

log
g
=

4.11

−
0.18

+
0.11

dex, and a mass of M =

6.3

−
1.9

+
1.5

M
Jup based on hot-start evolutionary models, leading to a mass ratio of

0.016

−
0.005

+
0.004

for the COCONUTS-2 system. COCONUTS-2b is the second coldest (after WD 0806−661B), and the second widest (after TYC 9486-927-1 b) exoplanet imaged to date. Comparison of COCONUTS-2b’s infrared photometry with ultracool model atmospheres suggests the presence of both condensate clouds and non-equilibrium chemistry in its photosphere. Similar to 51 Eri b, COCONUTS-2b has a sufficiently low luminosity (

log
(

L

bol

/

L

⊙

)
=
−
6.384
±
0.028

dex) to be consistent with the cold-start process that may form gas-giant (exo)planets, though its large separation means that such formation would not have occurred in situ. Finally, at a distance of 10.9 pc, COCONUTS-2b is the nearest imaged exoplanet to Earth known to date.
Toward Assembling a Comprehensive Database of Substellar Accretion Rates
Authors: Dacus Beck , Plunkett Cailin , Wang Huichen , Follette Katherine B. , Betti Sarah , Peck Anne , Robinson Connor , Ward-Duong Kimberly 
Published: July 2021

Abstract
The relationship between mass and mass accretion rate in young objects is a powerful tool for interrogating formation and evolution. We analyze a comprehensive database of published accretion diagnostics for ∼400 objects (0.005–2 M
⊙), including 64 brown dwarfs. To eliminate systematics between studies as the source of the four orders of magnitude of observed scatter, we uniformly re-estimate masses and accretion rates from direct observables (e.g., spectral types, line luminosities). In particular, we adopt a single grid of evolutionary models to estimate masses, a single family of scaling relations to estimate accretion luminosity, and update line luminosities using Gaia DR2 distances. We find that this unification produces minimal effects on the observed relation, suggesting systematic and methodological variation is not responsible for the scatter. This paves the way for investigation of physical sources of scatter, including: age variation, intrinsic variability, formation mechanism, and accretion paradigm.
Le Prince et la question constitutionnelle
Authors: Barthas Jérémie 
Published: July 2021

S’il est vrai que les faits politiques et la pensée politique interagissent, la connaissance de l’histoire rédactionnelle du Prince de Machiavel ne saurait être négligée sans s’exposer à de graves malentendus. Or, cette histoire est l’objet d’une controverse scientifique récurrente, mais qui repose sur une présomption universelle erronée : l’idée que Machiavel ne se résolut qu’en seconde intention à dédier Le Prince à Laurent de Médicis le jeune. Dans cette contribution, l’auteur propose un changement de paradigme et montre ce que la prise en compte de la Constitution florentine du 22 novembre 1513 révèle de cette histoire.
High carriage rate of intestinal parasites among asymptomatic HIV-seropositive individuals on antiretroviral therapy attending the tertiary care hospital in Varanasi, India
Authors: Purbey Manish Kumar , Singh Aradhana , Kumari Simmi , Banerjee Tuhina 
Published: July 2021

Introduction:
Infections by intestinal parasites (IPs) are prevalent among human immunodeficiency virus (HIV)-seropositive individuals. Although diarrhea is the usual manifestation, asymptomatic presentations are common. In such situations, the problem of parasitosis is often underestimated. This study was performed to assess the presence of IPs among asymptomatic HIV-seropositive patients.

Materials and Methods:
A case–control study was designed, including stool samples from 75 asymptomatic HIV-seropositive patients and 75 seronegative patients with gastrointestinal discomfort. IPs was identified by microscopy and polymerase chain reaction (PCR) for Entamoeba spp, Cryptosporidium and Microsporidium spp. The data were statistically analyzed using the Chi-square test.

Results:
The prevalence of IPs in HIV-seropositive cases (25.33%) was statistically significantly more (P < 0.05) than that of controls (4%). Helminths predominated in both the groups. PCR detected IPs in 5 (6.6%) additional microscopy-negative cases. The presence of IPs was associated with CD4 count <200 cells/μl.

Conclusion:
The asymptomatic carriage of IPs in HIV patients poses an important reservoir in the community. To prevent transmission, frequent screening is needed.
Assessment of preoperative thyroglobulin levels in papillary thyroid cancer
Authors: Melik Mehmet Ali , Baskonus Ilyas , Yilmaz Latif 
Published: July 2021

Background:
The papillary thyroid cancers (PTCs) are the most common cancer of endocrine cancers. The primary treatment is surgery, and the prognosis is mostly well. In spite of many methods for the early diagnosis, the simpler and noninvasive methods are being sought. The aim of this study is to find out whether the value of thyroglobulin (Tg) is related with PTC.

Materials and Methods:
Prospectively; we measured the preoperative Tg value of 203 (159 females and 44 males) patients who underwent a total thyroidectomy with various indications in General Surgery Department of Gaziantep University. Tg values of 61 patients with benign lesions and 142 patients with PTC were compared.

Results:
In the patients with PTC, the mean preoperative Tg value was 105.05 ng/ml and 76.80 ng/ml in the benign patients. According to receiver operating characteristic analysis, the cutoff point was determined 102 ng/ml. There was a statistically significant difference in preoperative Tg values between benign group and PTC (P < 0.05).

Conclusion:
Patients with a preoperative Tg values above 102 ng/mL may more likely to have PTC. It is thought that Tg levels may be accepted as a criterion for distinguish malignant/benign situations that should be supported with new studies.
Inter-fractional entrance dose monitoring as quality assurance using Gafchromic EBT3 film
Authors: Moon Sun Young , Jo Yunhui , Seo Jaehyeon , Shin Dongho , Yoon Myonggeun 
Published: July 2021

Introduction:
This study describes a simple method of inter-fractional photon beam monitoring to measure the entrance dose of radiation treatment using Gafchromic EBT3 film.

Materials and Methods:
The film was placed at the center of a 1-cm thick phantom shaped like a block tray and fixed on the accessory tray of the gantry. The entrance dose was measured following the placement of the film in the accessory tray. The dose distribution calculated with the treatment planning system was compared with the dose distribution on the irradiated EBT3 films. The effectiveness of this methodology, as determined by gamma passing rates, was evaluated for the 22 fields of eight three-dimensional conformal radiotherapy (3D-CRT) plans and the 41 fields of nine intensity-modulated radiotherapy (RT) plans. The plans for three-dimensional conformal RT included treatments of the rectum, liver, breast, and head and neck, whereas the plans for intensity-modulated RT included treatments of the liver, brain, and lung.

Results:
The gamma passing rates for 3D-CRT ranged from 96.4% to 99.5%, with the mean gamma passing rate for 22 fields being 98.0%. The gamma passing rate for intensity-modulated RT ranged from 96.1% to 98.9%, with the mean gamma passing rate for 41 fields being 97.7%. All gamma indices were over the 95% tolerance level.

Conclusions:
The methodology described in this study, based on Gafchromic EBT3 film, can be utilized for inter-fractional entrance dose monitoring as quality assurance during RT. Clinical application of this method to patients can verify the accuracy of beam delivery in the treatment room.
Safety and efficacy of Oro-T oral rinse in oral mucositis during cancer radiotherapy and/or chemotherapy
Authors: Koushik Kirthi , Janaki M. G. , Kumawat Rajesh , Paramesh Rangesh , Palaniyamma D 
Published: July 2021

Introduction:
Oral mucositis is inflammation of the mucosa of the mouth which ranges from redness to severe ulceration. It results from the local effects of radiation to the oral mucosa.

Objectives:
The study is cumulative analysis of two studies (one comparative and the other open labeled) evaluated in individuals with oral mucositis during cancer radiotherapy and/or chemotherapy for the safety and efficacy of Oro-T mouthwash in a comparative design with normal saline.

Methodology:
Both the studies were similar with respect to clinical and laboratory parameters for analysis. The participants were advised to use 10 ml of Oro-T for 1 min 4 times daily for 6 weeks starting from day 1 of standard care. Patients were followed up, and the results were assessed from baseline on visit days: At entry and at the end of every week for 6 weeks. Clinical assessment of oral condition was done objectively (by the investigator) and also subjectively. Clinical symptoms such as sore throat, number of ulcer, burning sensation, pain, difficulty in chewing, difficulty in drinking, and mucositis grading along with Patient Reported Outcome Measures Scale were evaluated at each interval. Data was available for 40 subjects in Oro-T and 15 subjects in NS groups respectively.

Results and Conclusion:
The significant positive outcome was reported both subjectively and objectively in Oro-T group as compared to NS group with the delay in the onset of symptoms and less severe manifestation of oral mucositis with an improvement in quality of life. No adverse effects were reported that prompted discontinuation of study medication. Overall compliance to study medication was good.
Green Military New Deal
Authors: Castillo-Vinuesa Eduardo , Gankevich Iuliia 
Published: July 2021

Among the most decisive challenges that the climate crisis will bring during up coming decades will be the necessity to overcome the current lack of planetary ecosystem governance. The void that exists where proper geopolitics should reside demands a recalibration of the focus of design towards the conception, implementation, and support of new institutional models capable of reconfiguring established infrastructural, ecosystem and governance structures.
The rising awareness of the lack of ecological agency has recently led to the emergence of several proto-policies branded under the name of “Green New Deals” (GNDs): the green proposals across the world that aim to address climate change and economic inequality. However, the implementation of the GND’s goals requires not only the necessary infrastructural means for decarbonisation but also a set of social insurance mechanisms able to guarantee social stability during the transition to a new energy regime.
The complexity that this task poses in relation to society, the economy, manufacturing industries and goods and information logistics will require the establishment of an institution capable of intervening in the regulation and coordination of all the parties involved.
Green Military New Deal (GMND) is a research proposal that lies between the legislative models of ecosystem governance and the institutions capable of enforcing them. It speculates about the military establishment as a proto-platform that could fulfil the institutional gap created by the GND’s demands. Would it be possible to reimagine the military establishment as a trans-national ecological force capable of mobilising and enforcing proper ecosystem management, conscious of its ability to act as a welfare provider while deploying its technological resources?
Our research offers an informed approach toward this counterintuitive premise, uncomfortable as it may be, by forcing us to question how certain existing institutions could be properly repurposed to address issues of global necessity.
Rancangan Model Speed Brake Flaps Tipe Clamsheel sebagai Alat Peraga di Prodi Teknik Pesawat Udara Sekolah Tinggi Penerbangan Indonesia
Authors: Louis Latif Hendri , Kuntoaji Wahyu 
Published: July 2021

Melihat perkembangan tekonologi didunia penerbangan pada saat ini dirasakan sangat pesat, hal ini juga harus diiringi dengan alat – alat praktik yang harus mengikuti perkembangan teknologi tersebut untuk menunjang kegiatan belajar mengajar. Untuk menunjang kegiatan belajar mengajar maka dari itu penulis bermaksud untuk membuat permodelan alat peraga simulasi speed brake flaps yang terdapat pada pesawat terbang, dan mengenalkan sistim speed brake flaps yang terdapat pada pesawat terbang dan dapat pula memberikan gambaran secara umum mengenai sistim flight control mengenai speed brake flaps sehingga proses pengajaran dapat berhasil sesuai dengan tujuan dari syllabus yaitu siswa memiliki kemampuan untuk dapat memahami prinsip dasar dari struktur pesawat terbang serta memiliki kemampuan dasar melakukan perawatan, karena selama ini siswa hanya dapat membayangkan tidak pernah melihat secara langsung alat yang dipelajari. seed brake merupakan jenis flight control surface yang digunakan pada pesawat untuk meningkatkan gaya hambat (drag). Simulasi speed brake ini memberikan gambaran mengenai pengoperasian dan mekanisme kerja sebuah speed brake. Rancangan ini dibuat dengan sistim yang sederhana untuk memudahkan pengoperasian. Dalam perancangang, metode yang digunakan adalah Metode pustaka menggunakan buku – buku literatur dan metode eksperimen. Karena sifatnya hanya sebagai alat peraga, maka tekanan hidrolik yang dibutuhkan adalah rendah. Tekanan hidrolik yang digunakan untuk mengoperasikan rancangan alat peraga ini adalah 90 psi dengan beban pada sistim mekanikal sebesar 160,83 lbs. Sumber arus listrik yang digunakan untuk mengoperasikan rancangan alat peraga ini adalah 220V AC untuk menghidupkan motor listrik dengan daya 1 HP sehingga memutar pompa hidrolik tipe gear yang menghasilkan fluida bertekanan untuk pengoperasian. Dibutuhkan daya sebesar 766 Watt untuk mengoperasikan rancangan alat peraga ini.
Arduino: uma proposta para o ensino Introdutório de programação C/C++
Authors: De Oliveira Allison Lopes , Gonçalves Willian Antonio , Hoed Raphael Magalhães 
Published: July 2021

RESUMO
Este artigo apresenta uma proposta diferenciada de uma nova metodologia de ensino, apoiada por ferramentas computacionais que podem contribuir para a melhoria do aprendizado dos alunos do Curso Técnico em Informática do Instituto Federal do Norte de Minas Gerais (IFNMG), Campus Arinos. As dificuldades encontradas pelos alunos na elaboração de um raciocínio estruturado para a solução de um problema computacional, de compreensão de conceitos, e a complexidade dos ambientes de desenvolvimento são, frequentemente, obstáculos ao aprendizado. Tais problemas podem ser amenizados pelo uso didático de novas plataformas, construídas para facilitar à aprendizagem pela experimentação. Com o intuito de tornar as aulas atrativas, objetivas e com o foco no aluno, pretende-se aplicar a Plataforma Arduino que é uma excelente ferramenta para o ensino de conceitos de Lógica de Programação, além de ser um vasto repositório de recursos para experimentação prática, e um laboratório de baixo custo para testes de programas em C/C++. O Arduino une essas ferramentas, resultando num ambiente de aprendizado fácil, com recursos de interfaceamento para sensores e atuadores. A aplicação coordenada do Arduino, no contexto da disciplina Algoritmos, pode conduzir o aluno a um aprendizado facilitado, consistente e voltado a aplicações práticas.

ABSTRACT
This article presents a differentiated proposal of a new teaching methodology, supported by computational tools that can contribute to the improvement of the learning process of students of the Technical Course in Computer Science of the Federal Institute of Northern Minas Gerais (IFNMG), Arinos Campus. The difficulties faced by students in developing a structured reasoning to solve a computational problem, understanding concepts, and the complexity of development environments are often obstacles to learning. These problems can be alleviated by the didactic use of new platforms, built to facilitate learning through experimentation. In order to make the classes attractive, objective and student focused, we intend to apply the Arduino platform, which is an excellent tool for teaching Logic Programming concepts, besides being a vast repository of resources for practical experimentation, and a low cost laboratory for testing C/C++ programs. Arduino brings these tools together, resulting in an easy learning environment with interfacing capabilities for sensors and actuators. The coordinated application of Arduino, in the context of the Algorithms course, can lead the student to a facilitated, consistent, and practical learning experience.
O oratório “Candomblé” de José Siqueira: do ritual religioso à obra de arte universal
Authors: Santos José Vianey 
Published: July 2021

Este artigo apresenta alguns resultados da pesquisa sobre o primeiro oratório do compositor José Siqueira, Candomblé (1958), no que diz respeito à sua gênese, histórico e características musicais. Com uma revisão musical, pretendemos desfazer as discrepâncias entre a grade e a partitura de ensaio para unificar o discurso entre os dois documentos. Utilizamos também a gravação de Moscou (1975) para comparar com as partituras, observando detalhes sobre a prática interpretativa. A partir da revisão, ampliamos o estudo para a elucidação do texto em nagô, objetivando a compreensão para o aprimoramento na prática interpretativa. Estudamos a cultura nagô no contexto da liturgia do candomblé, notadamente sob a ótica das influências da cultura iorubá e tendo como base a região de Salvador, Bahia, onde o compositor coletou o material para seu oratório. Pretendemos situar o Candomblé no cenário da música de concerto no Brasil e no mundo, destacando suas particularidades e inovações.
Penggunaan Media Audiovisual Dengan Power Point di Tengah Pandemi dalam Pembelajaran Pendidikan Kewarganegaraan di Madrasah Ibtidaiyah
Authors: Dea Lita Salsabila  , Heri Hidayat  , Heny Mulyani  , Dini Arlina  , Delfianti Azzahra  
Published: July 2021

The use of audiovisual media is a strategy in student learning to determine the effect and development of teacher performance on students. During the Covid-19 pandemic, Civics learning, especially in Islamic Elementary School and Elementary School, contained audiovisual learning using Power point as a tool for presenting material that was well known among users of personal computers and laptops. In this study using several research methods in the form of secondary data with observations and experiences in accordance with the theme of learning through the media as well as utilizing library resources. Through the Audiovisual facility with Power Point, it shows the results of research in the form of the development of the reasoning power of students who are capable of actually being and increasing the learning process for students to a more professional level in the use of learning technology.
Reasoning through the Gut: The Microbiota-Gut-Brain Axis and its Role in the Pathogenesis of Autism Spectrum Disorder
Authors: Singh Shreyas , Dalton Avan Erhunmwunsee 
Published: July 2021

The age-old phrase ‘gut feeling’ is increasingly finding a scientific basis. The human gut houses a massive colony of microorganisms that not only maintain intestinal function, but also have far-reaching connections to the brain through a complicated ‘microbiota-gut-brain’ (MGB) axis. This axis has now been established to have implications in the management of various neuro-psychological conditions including Autism spectrum disorder (ASD), a condition that affects the way people communicate, behave and interact with others. Once considered a rare disorder, it is now estimated to have a prevalence of about 1 in 54 children in the United States. It is unfortunate that the existing cognitive-behavioral therapy protocols for ASD are prolonged and expensive, and that there is no currently approved medication for the core symptoms of the disorder. Scientists are now exploring the MGB axis for establishing possible therapeutic targets to alleviate the symptoms of ASD. This review attempts to highlight how the MGB axis works, and to capture the essence of the mechanisms that implicate the MGB axis in the pathogenesis of ASD. Further research in this direction may convincingly establish the role of novel treatment options for ASD ranging from probiotics and dietary modifications to newer modalities like fecal transplants, vagal nerve stimulation and gene therapy. Microbes, and not just behavioral intervention therapy, may hold the key to treating ASD.
Аҳоли турмуш даражаси ва фаровонлигини ошириш омиллари (Бухоро вилояти мисолида)
Authors: Холмуродов Нозимжон 
Published: July 2021

Мақолада аҳоли турмуш даражаси ва фаровонлигини ошириш борасида мамлакатимизда қабул қилинган ҳуқуқий ҳужжатлар мазмуни очиб берилган. Мамлакатимизда камбағалликни қисқартириш ва аҳоли турмуш даражасини ошириш борасида амалга оширилган чора тадбирлар Бухоро вилояти мисолида таҳлил қилинган. Ўзбекистон Республикасида камбағалликни қисқартиришга қаратилган ислоҳотлар мазмуни ёритиб берилган.
Prognostic model and immune-infiltrating cell landscape based on differentially expressed autophagy-related genes in TP53-mutated multiple myeloma
Authors: Zheng Yan-Hua , Shen Hong-Yuan , Chen Xiang , Feng Juan , Gao Guang-Xun 
Published: July 2021

IntroductionAutophagy functions as a prosurvival mechanism in multiple myeloma (MM).The objective of this research was to establish an autophagy-related gene (ARG) signature for predicting the survival outcomes of MM patients with TP53 mutations.Material and methodsInformation about MM patients with TP53 mutations was downloaded from Gene Expression Omnibus (GEO) database. Cox proportional hazard regression was employed to determine the independent prognostic ARG and construct a risk signature. Time-dependent receiver-operating characteristic (t ROC) curve was used to explore the predictive accuracy of the prognostic model. A nomogram was constructed to give a more precise prediction of the probability of 5-year, 8-year and 10-year overall survival (OS). In addition, we utilized the CIBERSORT algorithm to explore the distribution difference of 22 immune-infiltrating cells.ResultsThree differentially expressed ARGs (CASP8, MAPK8, RB1CC1) were finally incorporated to construct the risk model. Area under the curve (AUC) of corresponding tROC curve for 5-year,8-year and 10-year OS were 0.735, 0.686 and 0.662, respectively. MM patients were categorized into high and low-risk group in accordance with the median threshold value (-1.724549). ARG-based risk score model was an independent prognostic element correlated with OS, giving an hazard ratio (HR) of 3.29 (95%CI 2.35-4.60, P<0.001). 13 immune infiltrating cells were found to have distribution differences between the two groups.ConclusionsWe established a three-ARGs risk signature which manifested an independent prognostic factor. The nomogram was testified to perform well in forecasting the long-term survival of TP53-mutated MM patients.