bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of prolactin in central nervous system inflammation
Authors: Ramos-Martinez Edgar , Ramos-Martínez Ivan , Molina-Salinas Gladys , Zepeda-Ruiz Wendy A. , Cerbon Marco 
Published: January 2021

Abstract
Prolactin has been shown to favor both the activation and suppression of the microglia and astrocytes, as well as the release of inflammatory and anti-inflammatory cytokines. Prolactin has also been associated with neuronal damage in diseases such as multiple sclerosis, epilepsy, and in experimental models of these diseases. However, studies show that prolactin has neuroprotective effects in conditions of neuronal damage and inflammation and may be used as neuroprotector factor. In this review, we first discuss general information about prolactin, then we summarize recent findings of prolactin function in inflammatory and anti-inflammatory processes and factors involved in the possible dual role of prolactin are described. Finally, we review the function of prolactin specifically in the central nervous system and how it promotes a neuroprotective effect, or that of neuronal damage, particularly in experimental autoimmune encephalomyelitis and during excitotoxicity. The overall studies indicated that prolactin may be a promising molecule for the treatment of some neurological diseases.
Legal reasoning: a textual perspective on common law judicial opinions and Chinese judgments
Authors: Lu Nan , Yuan Chuanyou 
Published: January 2021

Abstract
The issue of legal reasoning has been addressed widely in legal academia and practice, but rarely considered by linguists. This paper, employing the Systemic Functional Linguistics (SFL) genre perspective and the discourse semantics system as its conceptual framework, attempts to reveal the different ways of legal reasoning of common law judicial opinions and Chinese judgments from a textual perspective. One judicial opinion of a British case and one judgment of a Chinese case are explored for comparison. The findings suggest that Chinese judgments as a legal genre, compared with its counterpart of common law judicial opinions, unfold not in waves construed by multilayered Theme-and-New structure, but in chunks establishing no prediction or consolidation. We argue that this mode of text unfolding in waves is vitally important for readers to follow the judge’s reasoning and construct a sense of fairness and justice. We suggest that the periodicity and the generic structure of common law judicial opinions would be a valuable frame of reference for the Chinese judicial reform on judgments in improving its legal reasoning.
Knowledge and Awareness Regarding Premarital Screening of β-thalassemia among Undergraduate Students in Bangladesh
Authors: Pervin Samina , Sultana Hafiza , Ahmed Tanvir , Haque Aysha , Abbas Md. Golam , Hasan Md Mahmudul 
Published: January 2021

Introduction: Thalassemia is the most common congenital single gene disorder in Bangladesh. Considering the nature of the disease inherited from parents, thalassemia can effectively be prevented by premarital blood screening before marriage. The aim of the study was to assess the level of knowledge and awareness regarding premarital screening of β-thalassemia among undergraduate students.
Materials and Methods: This cross sectional study was conducted among conveniently selected 156 undergraduate students of 2 universities at Dhaka University and American International University-Bangladesh (AIUB) from January to December 2019. Data were collected by pretested semi-structured questionnaire through face to face interview. Data was analyzed using SPSS software version 23.

Results: It was found that about 49.5%, 43.6% and 7.1% of respondents had poor, average and good knowledge about premarital screening of β-thalassemia respectively where there was statistical significance between the level of knowledge and the parental consanguinity and the family history of thalassemia (p-value<.05). On the other hand, 66.7%, 32.1% and 1.3% had poor, average and good awareness in this regards respectively. The level of awareness was significantly associated with the parental consanguinity, family history of thalassemia, monthly income and family type (p-value<.05).

Conclusion: This study showed knowledge and awareness levels among undergraduate students regarding premarital screening of β-thalassemia were insufficient. The thalassemia prevention can be enhanced by a well-organized educational program focusing on thalassemia and early screening in young adults.

Keywords: Thalassemia; gene disorder; premarital blood screening
Avaliação da qualidade do serviço online prestado pelos aplicativos móveis para delivery utilizando a escala SERVQUAL adaptada
Authors: Potzik Fabiola De Mattos , Pierre de Messias Luana Costa , Oliveira Sérgio Luis Ignácio de , Gonçalves de Oliveira Paulo Sergio 
Published: January 2021

Este artigo de caráter descritivo, tem como objetivo avaliar a qualidade do serviço online prestado por aplicativos móveis para delivery de refeição, identificando as necessidades de quem utiliza o serviço e apontar os fatores mais críticos. Os métodos empregados para obtenção dos dados foram à pesquisa bibliográfica e documental. A amostra do artigo foi composta por respondentes que conheciam ou não os aplicativos para pedido e delivery de refeição. O levantamento foi realizado através da internet, por meio de formulário do Google Docs. A aplicação do questionário ocorreu no período de abril a junho de 2017, e obteve-se 110 respostas, das quais todas foram consideradas válidas para fins de pesquisa. Através da análise fatorial os dados obtidos com o questionário foram avaliados, e verificou-se a variância explicada pelo modelo, cuja extração foi efetuada pelo método das “Componentes Principais” e a rotação pelo método “Varimax”, gerando uma solução de três constructos, que explica cerca de 70% da variância total. A análise seguinte foi à verificação da confiabilidade interna dos constructos por meio do uso do Alpha de Cronbach para cada um dos três constructos gerados. Os resultados do artigo apontam os fatores determinantes para a aplicação e ampliação de canais de Marketing voltados para delivery de refeições, a segurança no processo de transferência patrimonial e facilidades na interface gráfica dos aplicativos.
Consumidores: Sujeitos Multifacetados e Incontroláveis.
Authors: Moura Renan Gomes de 
Published: January 2021

O que seria consumir? Quem são os consumidores? O que consomem? Como consomem? O que significa para o consumidor ser 'incontrolável'? O que isso implica para o futuro do consumismo? E há alguma esperança aqui para o futuro do planeta? O consumo passou a ocupar um espaço central na vida dos indivíduos, uma vez que esse passou a ser uma das formas de se constituir a identidade dos sujeitos, de demonstrar status social, como uma forma de se entrar em grupo social etc. Posta essa centralidade na vida dos sujeitos Yiannis Gabriel e Tim Lang buscam no livro The Unmanageable Consumer mostrar como os consumidores, se mostraram imprevisíveis, contraditórios e incontroláveis, exibindo muitas faces e imagens diferentes.
PTP1B INHIBITORS FROM ISODON TERNIFOLIUS COLLECTED IN VIETNAM
Authors: Phi-Hung Nguyen 
Published: January 2021

From the whole plant of Isodon ternifolius collected in Vietnam, four triterpens including ursaldehyde (1), ursolic acid (2), b-sitosterol (3) and b-sitosteryl ferulate (4) were purified. Their chemical structures were determined by interpretation of NMR and MS data and comparison with the literatures. Compounds 1-4 were evaluated for their inhibitory activity against PTP1B enzyme activity using in vitro assay. Compounds 1 and 2 displayed potential activities with IC50 values of 16.92 ± 0.12 and 3.42 ± 0.45 μM, respectively. This is the first time that compounds 1 and 4 have been isolated from the Isodon genus and I. ternifolius has been evaluated for the PTP1B inhibitory activity.
COMBINATION IMPACT OF pH AND TEMPERATURE ON THE TOXICITY OF LEAD ON ZOOPLANKTON IN THE CONTEXT OF GLOBAL WARMING
Authors: Thu-Huong Hoang Thi , Pham Hong Thi , Nguyen Chung Thuy , Nguyen Hien Thi Thu 
Published: January 2021

Heavy metal pollution in urban lakes of Hanoi has become one of the major environmental issues in the last decades. Research on the toxicity of Pb is necessary due to the extent of its harm to aquatic ecosystems. The toxicity of Pb to aquatic organisms (EC50 values) depends on different environmental conditions. The study was conducted to evaluate the effect of temperature on the toxicity of Pb on the test organism Moina Dubia. Moina Dubia belongs to the Cladocera group (Cladocera) which is an indigenous creature collected at Lake Hanoi. Moina Dubia was cultured under laboratory conditions and has been used to conduct EC50 determination for Pb. Moina Dubia grew and developed well in the laboratory and was suitable as a test organism in toxicological studies. A survey from 24oC to 28oC water temperature conditions showed that the EC50 value decreases from 1402 ug/l to 775 ug/l. The higher water temperature, the higher toxicity level of Pb on Moina Dubia. Clear impact of water temperature on toxicity of heavy metal as Pb showed that global warming may gradually lead to potential biodegradation in freshwater ecology.
The interaction between [Pt(µ-Cl)(Safrole-1H)]2 and 1,3-diisopropylbenzimidazolium bromide in the presence of Ag2O
Authors: Mai Nguyen Thi , Thao Pham Thi Minh , Chi Nguyen Thi Thanh 
Published: January 2021

The interaction of the dimeric complex [Pt(µ-Cl)(Saf)]2 (1) (Saf: deprotonated safrole) with the salt iPr2-bimy·HBr in the presence of Ag2O in acetone solvent was studied. The obtained products were mixed complexes of [PtCl(Saf)(iPr2-bimy)] (2) and [PtBr(Saf)(iPr2-bimy)] (3) with different molar ratio (PI, PII, PIII) depended on the used molar ratio of 1:salt:Ag2O. In the case of this ratio being 1:2:1.1, the mixture PI with 75% for the complex 2 was obtained. When concentration of the salt was increased, the product was PII with the molar ratio of 2 : 3 of 1 : 3. However, when both the salt and Ag2O were increased at the same time, 2 and 3 in PIII had equal molar proportions. The two main factors affecting the 2 : 3 molar ratio are the different solubility of AgCl and AgBr and the different coordinating ability of Cl- and Br- ligands. The structure of 2 and 3 was determined by 1H NMR spectra and single crystal X-ray diffraction. The results reveal that Saf in 2 and 3 coordinates with Pt(II) via C=Colefinic and C5 of benzene ring. Meanwhile, iPr2-bimy coordinates with Pt(II) through CNCN and is in trans-position compared with the C=Colefinic bond.
George Florovsky’s critique of the Russian eligious-philosophical renaissance: an attempt at evaluation
Authors: Obolevitch Teresa 
Published: January 2021

In the present paper I present a project of Neopatristic synthesis by prominent Russian thinker Fr. George Florovsky, as well as the main reasons for which he criticised the existing style and direction of development of Russian thought in the form of religious-philosophical renaissance, or “the Silver Age.” By engaging in polemics with Florovsky’s approach, I advance four remarks. First, Florovsky himself was under the influence of the Russian religious-philosophical renaissance. Second, it was not Florovsky who initiated the Patristic studies in Russia, since they had been conducted from the 18th century. Third, the Neopatristic synthesis and the “Silver Age” philosophy could have been perceived as complementary projects rather than contrary in their tenor. Fourth, Florovsky left his own postulate uncompleted. In the concluding part of the paper I compare Florovsky’s and Zenkovsky’s approaches, arguing in favour of the latter thinker.
New strategy of color and power doppler sonography combined with DMSA in the assessment of acute pyelonephritis in infants
Authors: Chen Min Guang , Yang Yan , Yang Qing , Zhuang Jie Qiu , Ye Xiao Hua , Zheng Wen Jie 
Published: January 2021

Abstract
Background: The purpose of this study was to evaluate the clinical value of color and power doppler sonography (CPDS) when combined it with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA) in assessment of acute pyelonephritis (APN) in infants. Methods: A total of 79 children with APN admitted to our hospital from June 2016 to Jan 2019 were enrolled, including 52 boys and 27 girls, age range 1 month to 3 years old. All cases followed the diagnostic criteria for acute pyelonephritis and excluded anatomical abnormalities of urinary system. All 79 patients were examined by urinary ultrasonography (US), CPDS, and DMSA within 48 hours of fever and analyzed the clinical value of combining the two methods in the assessment of APN in infants. Results: Among 79 children, urinary ultrasonography revealed 2 cases of renal cortical echo changes, both located in the upper pole of the kidney, 24 cases of kidney enlargement, and 1 case of left kidney shrinkage. 95 kidneys were shown to be diseased with DMSA, while 105 kidneys abnormal by CPDS. The sensitivity of CPDS was 69.4%, and the specificity was 38.1%. In children younger than 6 months, the sensitivity of CPDS was 56.9%, which was 84.2% in childeren between 6 months to 1 year, and 94.4% from 1 to 3 years old, respectively. The corresponding specificity of CPDS was 44.1%, 26.7%, and 35.7%. There was no significant correlation between CPDS levels and DMSA positive results. The abnormal rate of intermediate part in the kidneys was significantly lower than that in the upper and lower poles. Children with abnormal CPDS have a greater risk of renal scarring(p<0.05). Conclusion: The clinical application value of CPDS is not as good as that of DMSA. But the sensitivity of CPDS is highly age-related, it can be used as a non-invasive helpful tool for early diagnosis of acute pyelonephritis in infants older than 6 months old.
Results of a Patient Reported Experience Measure (PREM) to measure the rare disease patients and caregivers experience: A Spanish cross-sectional study
Authors: Mora Mercedes Guilabert , Martínez-García Alba , Sala-González Marina , Solas Olga , Mira José Joaquín 
Published: January 2021

Abstract
Objective. To measure the experience of the person having a rare disease in order to identify objectives for optimal care in the health care received by these patients. Methods. A cross-sectional study was conducted in Spain involving patients associated with the Spanish Rare Diseases Federation [Federación Española de Enfermedades Raras] (FEDER). A modified version of the PREM IEXPAC [Instrumento para evaluar la Experiencia del Paciente Crónico] instrument was used (IEXPAC-rare-diseases). Scores ranged between 0 (worst experience) and 10 (best experience).Results. A total of 261 caregivers (in the case of paediatric population) and patients with rare diseases (response rate 54.4%) replied. 232 (88.9%) were adult patients and 29 (11.1%) caregivers of minor patients. Most males, 227 (87%), with an average age of 38 (SD 13.6) years. The mean time since confirmation of diagnosis was 7.8 (SD 8.0) years. The score in this PREM was 3.5 points out to 10 (95%CI 3.2-3.8, SD 2.0). Caregivers of paediatric patients scored higher, except for coordination of social and healthcare services.Conclusions. There are wide and important areas for improvement in the care of patients with rare diseases. This study involves a first assesment of the experience of patients with rare diseases in Spain.
A systematic review of interventions to improve acute hospital care for people with dementia
Authors: Karrer Melanie , Schnelli Angela , Zeller Adelheid , Mayer Hanna 
Published: January 2021

Abstract
The aim of this study was to provide an overview of interventions targeting hospital care of patients with dementia. We conducted a systematic review, including interventional study designs. We searched five electronic databases, conducted a hand search and performed citation tracking. To assess risk of bias, we used Cochrane Collaboration’s tool, ROBANS and AMSTAR. We narratively summarized the outcomes.The findings of twenty studies indicated a broad range of interventions and outcomes. We categorised the interventions into eight intervention types. Educational programmes were the most reported intervention type and resulted in improved staff outcomes. Family-/person-centred care programmes, use of specially trained nurses and delirium management programmes were effective in improving patient-related outcomes. However, current evidence is insufficient to declare which interventions are effective in improving dementia care in acute hospitals. Future research should focus on relevant patient and family caregiver outcomes and must to consider the complexity of the interventions. Trial registration: PROSPERO: CRD42018111032.
KLF14 Inhibits Renal Mesangial Cell Proliferation by Promoting Btg2 Gene Expression
Authors: Wu Xiaoyuan , Ma Yuxiang , Lian Xiaoying , Lin Shupeng , Shang Shunlai , Bai Xueyuan 
Published: January 2021

Abstract
Krüppel-like factor 14 is one of zinc finger protein family that are closely associated with regulation of transcription, and its function in the kidneys remains unclear. So KLF14-deficient mouse models were established using TALEN. The levels of blood cholesterol, HDL-C, LDL-C, and TGs were significantly decreased in KLF14-/- mice. KLF14-/- mice had more obvious mesangial cell proliferation and greater accumulation of extracellular matrix. RNA-Seq showed that these differentially expressed genes were mainly involved in metabolism, proliferation and inflammation pathways. ChIP-Seq was performed to identify KLF14 target genes. Five overlapping KLF14 target genes (Btg2, Socs2, Hdc, Ler2 and Akr1b3) were identified by combined analyses of RNA-Seq and ChIP-SEq. Dual luciferase reporter assay and EMSA confirmed that Btg2 was a target gene of KLF14. EdU assay revealed that KLF14 could inhibit the proliferation of primary renal mesangial cells by promoting Btg2 expression. KLF14 might exert its function in kidneys by regulating metabolism, proliferation, and inflammation signaling pathways. KLF14 inhibited the proliferation of primary RMCs by promoting expression of its target gene Btg2. This study provides a basis for further functional studies of KLF14 in the development of kidney diseases, especially in mesangial proliferative glomerulonephritis, metabolic nephropathy and kidney tumors.
Nonvolatile Memristor-Based Reservoir Computing System with Reservoir Controllability
Authors: Jang Yoonho , Kim Ji Hun , Woo Gyung Seok , Lee Hyun Jae , Kim Woohyun , Jeon Jeong Woo , Hwang Cheol Seong 
Published: January 2021

Abstract
Recent advances in reservoir computing (RC) using memristors have made it possible to perform complicated timing-related recognition tasks using simple hardware. However, the fixed reservoir dynamics in previous studies have severely limited application fields. In this study, RC was implemented with a reservoir that consisted of a W/HfO2/TiN memristor (M), a capacitor (C), and a resistor (R), in which the reservoir dynamics could be arbitrarily controlled by changing their parameters. After the capability of the RC to identify the static MNIST data set was proven, the system was adopted to recognize the sequential data set [ultrasound (malignancy of lesions) and electrocardiogram (arrhythmia)] that had a significantly different time constant (107 vs. 1 s). The suggested RC system feasibly performed the tasks by simply varying the C and R, while the M remained unvaried. These functionalities demonstrate the high adaptability of the present RC system compared to the previous ones.
Iranian HPV-positive Women's Needs and Preferences in Relation to Receiving Health Services: A Qualitative Study
Authors: Qaderi Kowsar , Geranmayeh Mehrnaz , Farnam Farnaz , Hasani Shahrzad Sheikh , Mirmolaei Seyedeh Tahereh 
Published: January 2021

Abstract
Background: HPV testing is performed in primary care, and in case of abnormal results, the patient is referred to specialized care for follow-up and treatment. Participating in HPV test and receiving an HPV diagnosis can create adverse psychosocial responses. In developing countries that HPV testing recently has been integrated in cervical cancer screening program, to enhance the quality of health services provided to HPV-positive women we need to assess their perceptions. This qualitative study aims to explore HPV-positive women's needs and experiences of receiving health services. Methods: We conducted 40 semi-structured interviews with HPV-positive women. Recorded interviews transcribed and analyzed using conventional content analysis approach.Results: Women sought information on HPV types, transmission, prevalence, and clearance. They also required information about other STIs, potential benefits of HPV vaccine, and the risk of HPV-related cancers. Women with abnormal cytology asked about HPV cofactors for cervical cancer. Participants sought ways to improve immunity and sexual health. HPV-positive women's expectations of health care providers (HCPs) include professional principles, communication and counseling skills and HPV-knowledge. Women prefer that HCPs treat them with non-judgmental attitude and do not ask for HIV/hepatitis tests immediately after HPV-diagnosis. "Precancerous" and "high-risk" words and watching colposcopy monitor during procedure had made women anxious. Weak referral system and limited interactions among gynecologists and other HCPs highlighted by participants.Conclusion: The results of this study, based on the experiences and perceptions of HPV women receiving health care, contain messages to healthcare providers at the primary and specialized levels of care to facilitate patient-provider communication around HPV. These practical tips will improve the quality of care for HPV-positive women.
Evaluation of Clinical Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma via Bioinformatics
Authors: Chen Cheng , Tang Yang , Qu Wendong , Han Xu , Zuo Jiebin , Cai Qingyong , Xu Gang , Song Yongxiang , Ke Xixian 
Published: January 2021

Abstract
Background: Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported. Herein, this study analyzed the clinical significance and potential mechanisms of MTFR2 in LUAD via bioinformatics tools.Results: We found that the level of MTFR2 was increased, and correlated with sex, age, smoking history, neoplasm staging, histological subtype and TP53 mutation status in LUAD patients. Kaplan-Meier survival analysis showed LUAD patients with increased MTFR2 had a poor prognosis. In addition, univariate COX regression analysis showed neoplasm staging, T stage, distant metastasis and MTFR2 level were risk factors for the prognosis of LUAD. A total of 1127 genes were coexpressed with MTFR2, including 840 positive and 208 negative related genes. KEGG and GSEA found that MTFR2 participated in the progression of LUAD by affecting cell cycle, DNA replication, homologous recombination, p53 signaling pathway and other mechanisms. The top 10 coexpressed genes, namely CDK1, CDC20, CCNB1, PLK1, CCNA2, AURKB, CCNB2, BUB1B, MAD2L1 and BUB1 were highly expressed, and were associated with poor prognosis in LUAD. Conclusions: Consequently, we elucidated MTFR2 was a biomarker for diagnosis and poor prognosis in LUAD, and might participate in the progression of LUAD via affecting cell cycle, DNA replication, homologous recombination and p53 signaling pathway.