bluuebunny/crossref_metadata_2025_split huggingface dataset:
Years of Life Lost Due to Main Causes of Deaths in Yazd Province, Iran
Authors: Askari-Nodoushan Abbas , Sabbaghchi Maryam , Mohammadi Masoud , Askari Maryam 
Published: May 2021

Aim One approach to measure the demographic impacts of death is to examine the number of lost years of life. The present paper aims to estimate the “Years of Lost Life” (YLL) due to the main causes of death in Yazd province of Iran. Method The present study is an epidemiological examination for which the statistical population included all the death incidents in Yazd province (excluding stillbirth cases) over two time periods of 2011 and 2016 with a 5-year distance. The required data were obtained based on the Comprehensive System of Mortality Registration maintained by the Ministry of Health and Medical Education; while the standard life expectancy data were based on the World Health Organization standards using standard life table, level 26 of the West model (Coale and Demeny) for Japanese men and women. The standard YLL was calculated according to the WHO standard using a 0.03 relaxation rate for the future time and weighting coefficient for various ages and life years through the formula using the Microsoft Excel software. Results The findings of the present study suggest that two main causes of YLL in Yazd province during the year of 2011 were cardiovascular difficulties with the rates of 31.6 per 1000 persons for women and 27.1 per 1000 persons for men, and cancers with the rates of 14.9 per 1000 persons for women and 16.2 per 1000 persons for men. While the above numbers in 2016 were, respectively 22.5 per 1000 persons for women and 25.5 per 1000 persons for men due to cardiovascular difficulties; and 18 per 1000 persons for women and 15.5/1000 for men due to various types of cancers. Conclusions Our findings suggest that cardiovascular diseases and cancers are the main factors leading to Years of Lost Lifetime for the residents of Yazd province in Iran.
Development and Application of an Interdisciplinary Rapid Message Testing Model for COVID-19 in North Carolina
Authors: Bartels Sophia M. , Gora Combs Katherine , Lazard Allison J. , Shelus Victoria , Davis C. Hunter , Rothschild Allison , Drewry Maura , Carpenter Kathryn , Newman Emily , Goldblatt Allison , Dasgupta Nabarun , Hill Lauren M. , Ribisl Kurt M. 
Published: May 2021

Introduction From the onset of the COVID-19 pandemic, public health officials have sought to develop evidence-based messages to reduce COVID-19 transmission by communicating key information to media outlets and the public. We describe the development of an interdisciplinary rapid message testing model to quickly create, test, and share messages with public health officials for use in health campaigns and policy briefings. Methods An interdisciplinary research team from the University of North Carolina at Chapel Hill assembled in March 2020 to assist the state health department in developing evidence-based messages to influence social distancing behaviors in the state. We developed and iteratively executed a rapid message testing model; the components of the 4-step model were message creation, survey development, survey administration, and analysis and presentation to health department officials. The model was executed 4 times, each during a 7-day period in April and May, and each subsequent survey included new phrasing and/or messaging informed by the previous week’s survey. A total of 917 adults from North Carolina participated in the 4 surveys. Results Survey participants rated messages focused on protecting oneself and others higher than messages focused on norms and fear-based approaches. Pairing behaviors with motivations increased participants’ desire to social distance across all themes and subgroups. For example, adding “Protect your grandmother, your neighbor with cancer, and your best friend with asthma,” to messaging received a 0.9-point higher score than the base message, “Stay 6 feet apart from others when out in public.” Practice Implications Our model to promote social distancing in North Carolina during the COVID-19 pandemic can be used for rapid, iterative message testing during public health emergencies.
Operative results after xiphoidectomy in patients with xiphodynia
Authors: Garssen Frank P , Aalders Margot B , van der Poel Marcel J , Zuidema Wietse P 
Published: May 2021

Background Xiphodynia, the painful xiphoid process, is a rare condition with an atypical presentation. Symptoms differ in severity and site, and can consist of chest, throat, and upper abdominal pain. Primarily, other more severe causes of these symptoms need to be excluded. After this exclusion as xiphodynia is diagnosed, treatment can consist of a multitude of options, since there is no consensus regarding the optimal treatment. The aim of this study was to describe the outcomes and efficacy of one of the options, namely surgical resection of the xiphoid in patients with xiphodynia. Methods In this retrospective case series, all consecutive patients that underwent xiphoidectomy for xiphodynia between January 2014 and December 2017 were included. Patients’ medical files including pre-operative work up, NRS scores, surgical outcomes, and follow up were reviewed. All patients received a questionnaire with follow-up questions. Results A total of 19 patients were included. None of the patients had surgery-related complications. Response rate of the questionnaire was 84% and showed that 94% of patients had an improvement of complaints after surgery, with 10 patients (63%) being totally pain free, after a mean follow-up from 34 months after surgery. Conclusions Xiphoidectomy is feasible and safe for the treatment of patients with xiphodynia with an improvement of complaints in nearly all patients.
Durability of suture versus ring tricuspid annuloplasty: Looking at very long term (18 years)
Authors: Carino Davide , Zancanaro Edoardo , Sala Alessandra , Ruggeri Stefania , Lapenna Elisabetta , Forno Benedetto Del , Verzini Alessandro , Schiavi Davide , Castiglioni Alessandro , Alfieri Ottavio , Bonis Michele De 
Published: May 2021

Background Several papers already reported better outcomes of tricuspid valve repair with ring annuloplasty compared to suture techniques. However, the follow-up is usually limited to 10 years. With this study, we aim to analyze the results of tricuspid valve repair according to the technique employed when the follow-up is extended to more than 15 years. Materials and methods A retrospective review of our institutional database was carried on to find all patients who underwent tricuspid valve repair between January 1998 and December 2004. Kaplan–Meier method was employed to estimate survival and log-rank test was used to make intergroup comparison. Cox regression was employed to identify risk factor for mortality. Cumulative incidence function using death as competitive outcome was used to estimate cardiac death. To describe the time course of tricuspid regurgitation, a longitudinal analysis using generalized estimating equations with random intercept for correlated data was performed. Results One hundred forty-six patients were identified: 89 in the suture group and 57 in the ring group. No difference in term of long-term survival and cardiac death was evident between the two groups. A significant higher rate of tricuspid regurgitation ≥2+ and ≥3+ recurrence was evident in the suture group during the whole follow-up (p < 0.001). Conclusion Our results corroborate the better results of tricuspid valve repair by means of ring implantation compared to suture techniques also when the follow-up is extended up to 18 years. Ring annuloplasty should be considered the first option for tricuspid valve repair due to a better durability.
Treatments for sleep disturbances in individuals with acquired brain injury: A systematic review
Authors: Pilon Louise , Frankenmolen Nikita , Bertens Dirk 
Published: May 2021

Objective: To systematically review the evidence on the treatments of sleep disturbances in individuals with acquired brain injury. Data sources: PubMed, Embase, Web of Science, and PsycINFO were searched from inception to January 2021. Review method: Eligibility criteria were (1) participants with mild to severe acquired brain injury from traumatic brain injury and stroke (⩾three months post-injury), (2) individuals aged 16 years and older, (3) participants with self-reported sleep disturbances, (4) controlled group studies and single case (experimental) studies, and (5) interventions aimed at treatment of sleep disturbances. Two researchers independently identified relevant studies and assessed their study quality using the revised Cochrane assessment of bias tool (RoB 2.0) and the risk-of-bias in N-of-1 trials (RoBiNT) scale. Results: The search yielded 655 records; 11 studies met the inclusion criteria and were included, with a total of 227 participants (207 individuals with traumatic brain injury, 20 stroke patients). Two studies included pharmacological therapy, six studies examined the effects of cognitive behavioral therapy and three studies investigated alternative interventions such as acupuncture. Conclusion: Although there was heterogeneity in the study quality of the included studies, their outcomes suggest that cognitive behavioral therapy is recommended as treatment of choice for improving sleep in individuals with acquired brain injury, especially for patients with mild to severe traumatic brain injury. Future research should examine the effects of cognitive behavioral therapy in more high-quality randomized controlled designs.
Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology
Authors: Chu Ying-Hsia , Rose William Nicholas , Nawrot William , Raife Thomas J. 
Published: May 2021

Background At our institution, patients with platelet refractoriness (of any etiology) are sometimes switched from apheresis platelets to pooled platelets before human leukocyte antigen (HLA)-matched units become available. Study design and methods Seven patients were analyzed. Platelet counts were available from 57 single-unit transfusions (26 pooled, 31 apheresis). A mixed linear effects model was used and significance was determined using a likelihood ratio test. Results When analyzed as the only fixed effect in the model, the use of pooled versus single-donor units and time from transfusion to post-transfusion blood sampling each showed a significant effect on platelet count increments. A mixed linear effect model including both factors showed that transfusing a pooled unit correlated with a 4500±2000/µL greater platelet count increment compared with a single-donor unit, and an increase in time from transfusion to post-transfusion blood sampling lowered the platelet count increment by 300±100/µL per hour. Conclusion A small but potentially clinically relevant benefit was observed in transfusing pooled random-donor platelets compared with single-donor units for patients with platelet refractoriness (of any etiology).
Association of Recurrent Tear After Arthroscopic Rotator Cuff Repair and Superoxide-Induced Oxidative Stress
Authors: Itoigawa Yoshiaki , Yoshida Keiichi , Nojiri Hidetoshi , Morikawa Daichi , Kawasaki Takayuki , Wada Tomoki , Koga Akihisa , Maruyama Yuichiro , Ishijima Muneaki 
Published: May 2021

Background: Recurrent tears after arthroscopic rotator cuff repair (ARCR) remain a significant clinical problem. Oxidative stress contributes to the degeneration of the rotator cuff, and a degenerative rotator cuff can lead to recurrent tear after ARCR. However, the correlation between oxidative stress and retear after ARCR is unclear. Purpose: To investigate the correlation between superoxide-induced oxidative stress and recurrent tear after ARCR. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 68 patients who underwent ARCR using a suture-bridge technique participated in this study. Specimens were collected from the edge of the torn tendon during surgery. The modified Bonar score was used to evaluate degeneration of the rotator cuff on histological specimens, and fluorescence intensity on dihydroethidium (DHE) staining was used to detect oxidative stress. Superoxide dismutase (SOD) enzyme activity was also measured. The following were used for clinical evaluation: age, tear size on magnetic resonance imaging (MRI) before surgery, Goutallier classification on MRI before surgery, and Japanese Orthopaedic Association score before and 6 months after surgery. After the repaired rotator cuffs were evaluated on MRI 6 months after surgery, the patients were divided into groups: those with a healed rotator cuff (healed group; n = 46) and those with a recurrent tear (retear group; n = 22). The significant differences between the groups were determined with regard to clinical evaluation, modified Bonar score, DHE intensity, and SOD activity. In addition, multivariate logistic regression analysis was performed to investigate risk factors for recurrent tear. Results: Age, tear size, Goutallier classification, modified Bonar score, DHE intensity, and SOD activity were significantly greater in the retear group than in the healed group, although the Japanese Orthopaedic Association score was not significantly different. Multiple logistic regression analysis demonstrated that age, tear size, and SOD activity were significantly correlated with recurrent tear. Conclusion: In addition to tear size and age, superoxide-induced oxidative stress may be an exacerbating factor for retear after ARCR.
A Randomized Controlled Trial of SGS-742, a γ-aminobutyric acid B (GABA-B) Receptor Antagonist, for Succinic Semialdehyde Dehydrogenase Deficiency
Authors: Schreiber John M. , Wiggs Edythe , Cuento Rose , Norato Gina , Dustin Irene H. , Rolinski Rachel , Austermuehle Alison , Zhou Xiangping , Inati Sara K. , Gibson K. Michael , Pearl Phillip L. , Theodore William H. 
Published: May 2021

We examined safety, tolerability, and efficacy of SGS-742, a γ-aminobutyric acid B (GABA-B) receptor antagonist, in patients with succinic semialdehyde dehydrogenase deficiency. This was a single-center randomized, double-blind crossover phase II clinical trial of SGS-742 versus placebo in patients with succinic semialdehyde dehydrogenase deficiency. Procedures included transcranial magnetic stimulation and the Adaptive Behavior Assessment Scale. Nineteen subjects were consented and enrolled; the mean age was 14.0 ± 7.5 years and 11 (58%) were female. We did not find a significant effect of SGS-742 on the Adaptive Behavior Assessment Scale score, motor threshold, and paired-pulse stimulation. The difference in recruitment curve slopes between treatment groups was 0.003 ( P = .09). There was no significant difference in incidence of adverse effects between drug and placebo arms. SGS-742 failed to produce improved cognition and normalization of cortical excitability as measured by the Adaptive Behavior Assessment Scale and transcranial magnetic stimulation. Our data do not support the current use of SGS-742 in succinic semialdehyde dehydrogenase deficiency. Trial registry number NCT02019667. Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency. https://clinicaltrials.gov/ct2/show/NCT02019667
A qualitative examination of graduating nurses’ response to the Covid-19 pandemic
Authors: Lancaster Rachelle J , Schmitt Catherine , Debish Melanie 
Published: May 2021

Background: Currently, graduating nurses face pandemic-related uncertainty including gaps in risk perception, unexpected Covid-19 moral dilemmas, and distress surrounding personal health risk. Research question/aim/objectives/Method: The purpose of this basic qualitative descriptive study is to describe the willingness of graduating nurses to provide care during the Covid-19 pandemic. Participants and research context: One week prior to graduation, students were required to submit a written assignment describing willingness to practice in light of the ongoing pandemic. Ethical considerations: This study was approved by an Institutional Review Board. Findings/results: Eighty-four ( n = 84) assignments were used for analysis. Of these, 82% (n = 69) of the graduating nurses describe a willingness to voluntarily care for Covid-19 patients. After summarizing narrative responses, two themes emerged including self-assessment of personal and familial risk and conflicting obligations. Discussion: The assessment of risk to self and family are key in determining whether graduating nurses will care for Covid-19 patients. Conflicting obligations may contribute to stress and uncertainty potentially leading to early burnout. Conclusion: Findings from this study can inform academicians of the need to adequality prepare graduating nurses for Covid-19-associated risks and ethical decision making. Organizations should alter residencies and orientation to support the needs of new nurses.
Maslow’s hammer: considering the perils of solutionism in mental healthcare and psychiatric practice
Authors: Looi Jeffrey C L , Bonner Daniel , Maguire Paul 
Published: May 2021

Objective: To discuss narrow pragmatism, manifest as digital and technical solutionism, in mental healthcare and psychiatric practice. Pragmatism is a view of the field of psychiatry as an instrument or tool for the purpose of providing psychiatric care for people with a mental illness. Solutionism, as proposed by Morozov, can be considered a special case of pragmatism that valorises an approach to solving real-world problems based on computation, algorithms and digital technology,1 which we extend to discuss other technical solutions such as medication, non-invasive brain stimulation and psychotherapy. Conclusions: Digital or technical solutionism may unnecessarily constrain approaches to mental healthcare and psychiatric practice. Psychiatrists can consider, and should advocate for, appropriate adaptation of technology and technical solutions toward collaborative and effective mental healthcare.
Social identities and mental well-being in autistic adults
Authors: Maitland Cameron A , Rhodes Sinead , O’Hare Anne , Stewart Mary E 
Published: May 2021

Social identities relate to psychological perceptions of group memberships and form part of the self-concept. Socially identifying with groups has previously been found to associate with better mental well-being outcomes. This study first examined the factor structure and the reliability of measuring social identification in autistic adults. Confirmatory factor analysis showed that a factor structure was replicated in this sample for social identification with other autistic people, but not the family. Second, the study assessed the level to which autistic adults socially identified with different groups, the total number of social identities and whether these were associated with their mental well-being. Autistic adults reported feelings of social identification with many kinds of groups, some with multiple groups, whereas others did not socially identify with any group. Stronger feelings of social identification towards other autistic people and towards one’s family, and with more groups overall, were associated with less severe self-reported depression symptoms and more facets of positive mental health. These findings indicate the importance of facilitating autistic people’s engagement with social groups. Lay abstract Social identities are groups that we are part of and influence how we think about ourselves. However, up until now there has been little examination of the groups that autistic people may belong to, and how these groups may influence their mental health. This survey-based study investigated whether autistic adults answer questions about social groups in a similar way to non-autistic non-autistic adults, including the types and number of social groups they may belong to, and whether these are associated with depression, anxiety and positive traits of mental well-being. In total, 184 autistic adults completed an online survey with questionnaires about their demographics, social groups and mental health. The results found that autistic adults reported on their social groups similarly to non-autistic people. There was a variety in the types and numbers of groups that autistic adults identified with. Some participants reported having no groups that they identified with, whereas others reported up to four groups. These included other autistic people, their family, friends, work colleagues and activity clubs among others. Autistic adults who felt connected with more groups reported better mental well-being. Feelings of connection to other autistic people and the family were also associated with better mental well-being. These results show that it is important for autistic people to be given opportunity to be part of groups that are meaningful to them, as this may be beneficial for their mental health.
COVID-19 healthcare policies in Ireland: A rapid review of the initial pandemic response
Authors: O’leary Noreen , Kingston Liz , Griffin Anne , Morrissey Ann-marie , Noonan Maria , Kelly Dervla , Doody Owen , Niranjan Vikram , Gallagher Aoife , O’riordan Clíona , Lynch Aoife 
Published: May 2021

Aims: Healthcare systems urgently required policies to guide the response to the COVID-19 pandemic. The aim of this review was to document the healthcare policies developed during the initial wave of widespread COVID-19 transmission in Ireland. We further sought to determine the key focus and impact of these policies. Methods: We conducted a rapid review of COVID-19 healthcare policies published from 28 January to 31 May 2020. Key information including the focus of the policy, target population and impact on service delivery was extracted from included policies. During analysis, data was grouped under descriptive categories and narrative summaries were developed for each category. Results: We identified 61 healthcare policies relating to COVID-19. We developed six category headings to describe the focus and impact of these policies: infection prevention and control ( n = 19), residential care settings ( n = 12), maintaining non-COVID-19 healthcare services and supports ( n = 12), testing and contact tracing ( n = 7), guidance for healthcare workers concerning COVID-19 ( n = 6), and treating COVID-19 ( n = 5). Conclusions: This review has identified lessons for policy development and implementation to help prepare for future healthcare emergencies. Factors to consider include support of vulnerable groups during and in the aftermath of the pandemic, providing psychological supports for healthcare workers and investment in public healthcare services such as contact tracing for future emergencies. While pandemic conditions necessitate the speedy development of policies, effective communication and adequate resourcing is required to ensure policy implementation.