bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic prescription practices and opinions regarding antimicrobial resistance among veterinarians in Kentucky, USA
Authors: Odoi Agricola , Samuels Ronita , Carter Craig N. , Smith Jackie 
Published: April 2021

Background
Inappropriate antimicrobial use (AMU) is a global concern. Opinions of veterinarians regarding AMU and its role in the development of antimicrobial resistance (AMR) may influence their prescription practices. It is important to understand these opinions, prescription practices and their potential impact on the development of AMR in order to guide efforts to curb the problem. Therefore, the objective of this study was to investigate the antimicrobial prescription practices and opinions of veterinarians in Kentucky regarding AMU and AMR.

Methods
This cross-sectional study used a 30-question survey questionnaire administered to veterinarians who were members of the Kentucky Veterinary Medical Association. Survey responses from 101 participants were included in the study. Descriptive statistics were computed and associations between categorical variables assessed using Chi-square or Fisher’s exact tests. Firth logistic models were used to investigate predictors of “Compliance with prescription policies” and “Cost of antimicrobial affects prescription decisions”.

Results
Almost all (93%) respondents indicated that improper AMU contributed to selection for AMR. A total of 52% of the respondents believed that antimicrobials were appropriately prescribed, while the remaining 48% believed that antimicrobials were inappropriately prescribed. Significant predictors of compliance with prescription policies were availability of prescription policy at the veterinary facility (Odds Ratio (OR) = 4.2; p<0.001) and over-prescription (OR = 0.35; p = 0.025). Similarly, significant predictors of cost of antimicrobials affecting prescription decisions were lack of post-graduate training (OR = 8.3; p = 0.008) and practice type, with large animal practices having significantly lower odds of the outcome (OR = 0.09; p = 0.004) than small animal practices.

Conclusion
Most veterinarians indicated that improper AMU contributed to selection for AMR. Since the odds of compliance with prescription policies were 4-times higher among veterinarians working at facilities that had prescription policies compared to those at facilities that didn’t, more veterinary facilities should be encouraged to adopt prescription policies to help improve compliance and reduce AMR. Veterinarians would also benefit from continued professional education to help improve prescription practices, antimicrobial stewardship and curb AMR.
Factor structure and construct validity of the short form of managing the emotions of others (MEOS-SF) scale in the Chinese sample
Authors: Wang Qianglong , Zhang Zhuo , Song Ping , Liu Zhenbiao , Zhang Qingyun , Vivino Anthony A. , Yang Bo , Hu Ping 
Published: April 2021

Objectives
Emotional manipulation is an important strategy in social interaction. The English version of MEOS-SF has been developed to make the measurement of such manipulation ability more efficient. The purpose of the current study was to assess the psychometric properties of the Chinese version of MEOS-SF.

Methods
Explore factor analysis and Confirmatory factor analysis were adopted to examine the Chinese version of the MEOS-SF factor structure in 645 Chinese participants (mean age = 24.68 ± 6.01 years) recruited online.

Results
Factor analysis supported a new three-factor model that included Conceal, Prosocial, and Non-prosocial, different from the original English MEOS-SF. Enhance and Divert merged to Prosocial factor while Worsen and Inauthentic merged to Non-prosocial factor because both prosocial and non-prosocial pairs had similar objectives, which would be perceived as the same thing by people in Eastern culture. As expected, MEOS-SF factors were found to be correlated with the Big Five, psychopathy, narcissism, Machiavellianism, and trait EI.

Conclusions
Our results suggested that the Chinese version of MEOS-SF had acceptable psychometric properties and could be used to assess emotional manipulation.
Association between early viral LRTI and subsequent wheezing development, a meta-analysis and sensitivity analyses for studies comparable for confounding factors
Authors: Kenmoe Sebastien , Bowo-Ngandji Arnol , Kengne-Nde Cyprien , Ebogo-Belobo Jean Thierry , Mbaga Donatien Serge , Mahamat Gadji , Demeni Emoh Cynthia Paola , Njouom Richard 
Published: April 2021

IntroductionConsideration of confounding factors about the association between Lower Respiratory Tract Infections (LRTI) in childhood and the development of subsequent wheezing has been incompletely described. We determined the association between viral LRTI at ≤ 5 years of age and the development of wheezing in adolescence or adulthood by a meta-analysis and a sensitivity analysis including comparable studies for major confounding factors.MethodsWe performed searches through Pubmed and Global Index Medicus databases. We selected cohort studies comparing the frequency of subsequent wheezing in children with and without LRTI in childhood regardless of the associated virus. We extracted the publication data, clinical and socio-demographic characteristics of the children, and confounding factors. We analyzed data using random effect model.ResultsThe meta-analysis included 18 publications (22 studies) that met the inclusion criteria. These studies showed that viral LRTI in children ≤ 3 years was associated with an increased risk of subsequent development of wheezing (OR = 3.1, 95% CI = 2.4–3.9). The risk of developing subsequent wheezing was conserved when considering studies with comparable groups for socio-demographic and clinical confounders.ConclusionsWhen considering studies with comparable groups for most confounding factors, our results provided strong evidence for the association between neonatal viral LRTI and the subsequent wheezing development. Further studies, particularly from lower-middle income countries, are needed to investigate the role of non-bronchiolitis and non-HRSV LRTI in the association between viral LRTI in childhood and the wheezing development later. In addition, more studies are needed to investigate the causal effect between childhood viral LRTI and the wheezing development later.Trial registrationReview registration: PROSPERO, CRD42018116955;https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018116955.
The economic burden of cervical cancer in Eswatini: Societal perspective
Authors: Ngcamphalala Cebisile , Östensson Ellinor , Ginindza Themba G. 
Published: April 2021

Background
Cervical cancer imposes considerable economic burden on societies and individuals. There is lack of evidence regarding this from the developing world and particularly from sub-Saharan Africa. Therefore, the study aimed to estimate the societal costs of cervical cancer in Eswatini.

Materials and methods
The cost of illness study (CoI) was applied using national specific clinical and registry data from hospitals, registries and reports to determine the prevalence of cervical intraepithelial neoplasia (CIN) and cervical cancer in Eswatini in 2018. Cost data included direct medical costs (health care utilization in inpatient and outpatient care), direct non-medical costs (patient costs for traveling) and indirect costs based on productivity loss due to morbidity (patient time during diagnosis and treatment) and premature mortality.

Results
The estimated total annual cost for cervical cancer was $19 million (ranging between $14 million and $24 million estimated with lower and upper bounds). Direct cost represented the majority of the costs at 72% ($13.7 million) out of which total pre-cancerous treatment costs accounted for 0.7% ($94,161). The management of invasive cervical cancer was the main cost driver with costs attributable to treatment for FIGO III and FIGO IV representing $1.7 million and $8.7 million respectively. Indirect costs contributed 27% ($5.3 million) out of which productivity loss due to premature mortality represented the majority at 67% ($3.5 million).

Conclusion
The economic burden of cervical cancer in Eswatini is substantial. National public health prevention strategies with prophylactic HPV vaccine and screening for cervical lesions should therefore be prioritized to limit the extensive costs associated with cervical cancer.
Estimation of salivary ferritin in children with childhood caries – a cross sectional study
Authors: Kotian Niharika , Gurunathan Deepa 
Published: April 2021

Objective: Early childhood caries is the presence of dental caries in a child upto seventy one months of age. Saliva plays a major role in maintaining good oral health. The composition of saliva acts as a marker for oral health and the salivary proteins help in modulating the oral microflora in the oral cavity. Some salivary biomarkers help in detecting caries risk and can also predict their prognosis. Ferritin is one of the major biomarkers present in the saliva which acts as an iron binding protein and also as a monitoring tool in children suffering from iron deficiency. The ferritin levels are in increased in serum as well as in saliva to balance the deficiency of iron in the body. Material and methods: Sixty children were selected for the study aged between three to six years. The saliva sample was collected using standard spit method in a sterile container and Ferritin was tested in the samples by Chemiluminescence microparticle immunoassay(CMIA). Results: Salivary ferritin was found to be higher in the saliva of children with early childhood caries(mean value= 5.867) than in children without early childhood caries(mean value= 3.412). Conclusion: A direct association is present between salivary ferritin levels and dental caries. Increased level of ferritin is observed in children with Early childhood caries. Clinical relevance: The level of salivary ferritin is found to be raised in the present study in children with Early childhood caries. The exact mechanism is although not known it can be assumed that the children with early childhood caries might have deficiency of iron which has led to the increased amount of salivary ferritin in the saliva.

Keywords
Salivary ferritin; Early childhood caries; Salivary proteins; Saliva; Iron deficiency
In-vitro efficacy of two spectrophotometer-based shade matching systems for color matching of ceramics after artificial accelerated aging
Authors: Alqahtani Fawaz 
Published: April 2021

Objective: The objective of the present invitro study was to verify the efficacy of two spectrophotometer-based shade matching systems for color matching of ceramics after artificial accelerated aging (AAA). Material and Methods: : The ceramics used were porcelain laminated veneers. Seventy standard-shaped discs (thickness x diameter: 0.5 mm x 10 mm) of B1 shades were used. Based upon the type of resin cement used, the specimens were divided into seven groups (10/group). The following light-cured cements were used: RelyX-Veneer (L-RV), Variolink-Veneer (L-VV), and VariolinkEsthetic (L-VE). The dual-cured cements were: RelyX Ultimate (D-RU), RelyX-Unicem (D-RC), and Variolink-Esthetics DC (D-VE). The control group consisted of ceramic only. All specimens were thermocycled in water for 3,500 cycles between 5 o C -55 o C, with dwell times of 30 s in each bath and a transfer time of 10 s between baths. All specimens were thermocycled in water for 3,500 cycles between 5 o C and 55 o C, and color measurement was done using the VITA Easyshade and ColorEye spectrophotometers. Baseline color reading was performed 24-hours after cementation. Differences in color (DE) of EasyShade and ColorEye before and after AAA were determined and compared statistically. Group comparisons were done using the paired t-tests. Level of significance was set at P< 0.05. Results: The mean differences in color (DE) values obtained from EasyShade spectrophotometer for light- and dual-cured cements, were 0.843±0.89 (Lc1), 4.11±0.69 (Lc2) and 0.833±0.47 (Lc3); and 2.22±0.64 (Dc1), 3.37±0.83 (Dc2) and 0.38±0.92 (Dc3), respectively. The mean differences in color (DE) values obtained from ColorEye spectrophotometer for light- and dual-cured cements, were 0.68±0.86 (Lc1), 4.55±0.83 (Lc2) and 2.68±0.26 (Lc3); and 2.06±0.84 (Dc1), 1.8±1.08 (Dc2) and 0.96±0.71 (Dc3), respectively. There was no significant difference in the mean DE values among the groups. Conclusion: The VITA Easyshade and ColorEye shade matching systems are comparable in terms of their efficacy for color matching of cerammics after AAA.

Keywords
Artificial accelerated aging; Color matching; In vitro; Porcelain veneer; Spectrophotometer.
Brand in focus: Activating adolescents’ persuasion knowledge using disclosures for embedded advertising in music videos
Authors: van Reijmersdal Eva A. , Opree Suzanna J. , Cartwright Robert F. 
Published: April 2021

Abstract
Many artists and music labels rely on partnerships with brands to pay for the production costs of their music videos. In exchange, the brands are featured in those videos. To enhance the transparency of these embedded forms of advertising, sponsorship disclosures are required. However, it remains unknown what the content of these disclosures in music videos should be to enhance sponsor transparency for adolescents. We examined how disclosure type affected adolescents’ conceptual and attitudinal persuasion knowledge. In addition, effects on responses toward the brand, music video, and artist were examined. An experiment (N = 279, ages 14–17) showed that none of the tested disclosures enhanced adolescents’ conceptual persuasion knowledge. However, disclosures explaining that the embedded brand helped pay for the production cost of the video led to lower attitudinal persuasion knowledge and, consequently, to more positive attitudes toward the brand, video, and artist, and to increased intentions to purchase the brand.
Pediatric diabetic ketoacidosis presenting with Streptococcus intermedius brain abscess
Authors: Mintz Judy L. , Jameson Morghan B. , Akinseye Leah , Los Evan A. 
Published: April 2021

Abstract

Objectives
Report a novel case of new-onset type 1 diabetes in a pediatric patient presenting with DKA and concurrent Streptococcus intermedius brain abscess.

Case presentation
The following case report is that of a previously healthy 12 year-old girl presenting with new-onset type 1 diabetes with mild diabetic ketoacidosis and subsequently found to have a brain abscess. Over the course of her hospital stay, she developed seizures and was found to have a 1.3 × 1.0 × 1.2 cm right frontal parasagittal mass culture-positive for S. intermedius. Neurologic symptoms were unmasked once insulin treatment was initiated and ketosis improved, supporting the relationship between therapeutic ketosis and the management of medication-refractory epilepsy.

Conclusions
This case both supports the relationship between therapeutic ketosis and the management of medication-refractory epilepsy and highlights the need to carefully consider comorbid conditions in patients with DKA and new onset neurological symptoms.
Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure
Authors: Elsaafien Khalid , Kirchner Matthew K. , Mohammed Mazher , Eikenberry Sophia A. , West Chloe , Scott Karen A. , de Kloet Annette D. , Stern Javier E. , Krause Eric G. 
Published: April 2021

The hypothalamic paraventricular nucleus (PVN) controls neuroendocrine axes and the autonomic nervous system to mount responses that cope with the energetic burdens of psychological or physiological stress. Neurons in the PVN that express the angiotensin Type 1a receptor (PVNAgtr1a) are implicated in neuroendocrine and autonomic stress responses; however, the mechanism by which these neurons coordinate activation of neuroendocrine axes with sympathetic outflow remains unknown. Here, we use a multidisciplinary approach to investigate intra-PVN signaling mechanisms that couple the activity of neurons synthesizing corticotropin-releasing-hormone (CRH) to blood pressure. We used the Cre-Lox system in male mice within vivooptogenetics and cardiovascular recordings to demonstrate that excitation of PVNAgtr1apromotes elevated blood pressure that is dependent on the sympathetic nervous system. Next, neuroanatomical experiments found that PVNAgtr1asynthesize CRH, and intriguingly, fibers originating from PVNAgtr1amake appositions onto neighboring neurons that send projections to the rostral ventrolateral medulla and express CRH type 1 receptor (CRHR1) mRNA. We then used anex vivopreparation that combined optogenetics, patch-clamp electrophysiology, and Ca2+imaging to discover that excitation of PVNAgtr1adrives the local, intra-PVN release of CRH, which activates rostral ventrolateral medulla-projecting neurons via stimulation of CRHR1(s). Finally, we returned to ourin vivopreparation and found that CRH receptor antagonism specifically within the PVN lowered blood pressure basally and during optogenetic activation of PVNAgtr1a. Collectively, these results demonstrate that angiotensin II acts on PVNAgtr1ato conjoin hypothalamic-pituitary-adrenal axis activity with sympathetically mediated vasoconstriction in male mice.SIGNIFICANCE STATEMENTThe survival of an organism is dependent on meeting the energetic demands imposed by stressors. This critical function is accomplished by the CNS's ability to orchestrate simultaneous activities of neurosecretory and autonomic axes. Here, we unveil a novel signaling mechanism within the paraventricular nucleus of the hypothalamus that links excitation of neurons producing corticotropin-releasing-hormone with excitation of neurons controlling sympathetic nervous system activity and blood pressure. The implication is that chronic stress exposure may promote cardiometabolic disease by dysregulating the interneuronal cross-talk revealed by our experiments.
Dissociating Perceptual Awareness and Postperceptual Processing: The P300 Is Not a Reliable Marker of Somatosensory Target Detection
Authors: Schröder Pia , Nierhaus Till , Blankenburg Felix 
Published: April 2021

A central challenge in the study of conscious perception lies in dissociating the neural correlates of perceptual awareness from those reflecting its precursors and consequences. No-report paradigms have been instrumental in this endeavor, demonstrating that the event-related potential P300, recorded from the human scalp, reflects reports rather than awareness. However, these paradigms cannot probe the degree to which stimuli are consciously processed from trial to trial and, thus, leave open the possibility that the P300 is a genuine correlate of conscious access enabling reports. Here, instead of removing report requirements, we took the opposite approach and equated postperceptual task demands across conscious and unconscious trials by orthogonalizing target detection and overt reports in a somatosensory detection task. We used Bayesian model selection to track the transformation from physical to perceptual processing stages in the EEG data of 24 male and female participants and show that the early P50 component scaled with physical stimulus intensity, whereas the N140 component was the first correlate of target detection. The late P300 component was elicited for both perceived and unperceived stimuli and was not substantially modulated by target detection. This was in stark contrast to a control experiment using a classical direct report task, which replicated the P50 and N140 effects but additionally showed a strong effect of target detection in the P300 time range. Our results demonstrate the task dependence of the P300 in the somatosensory modality and show that late cortical potentials dissociate from perceptual awareness even when stimuli are always reported.SIGNIFICANCE STATEMENTThe time it takes for sensory information to enter our conscious experience can be an indicator of the neural processing stages that lead to perceptual awareness. However, because many cognitive processes routinely correlate with perception, isolating those signals that uniquely reflect perceptual awareness is not a trivial task. Here, we show that late electroencephalography signals cease to correlate with somatosensory awareness when common task confounds are controlled. Importantly, by balancing report requirements instead of abolishing them, we show that the lack of late effects cannot be explained by a lack of conscious access. Instead, we propose that conscious access occurs earlier, at ∼150 ms, supporting the view that early activity in sensory cortices is a neural correlate of conscious perception.
A rare case of ectopic ACTH syndrome caused by primary renal neuroendocrine tumor
Authors: Chunharojrith Paweena , Pradniwat Kanapon , Kongmalai Tanawan 
Published: April 2021

Summary
Ectopic adrenocorticotropic hormone (ACTH) secretion is responsible for 5–15% of Cushing’s syndrome (CS). Neuroendocrine tumor (NET) is a common cause of ectopic ACTH syndrome (EAS). However, primary renal NET is exceedingly rare. Fewer than 100 cases have been reported and only a few cases presented with CS. Because of its rarity and lack of long-term follow-up data, clinical manifestations, biological behavior and prognosis are not well understood. Here, we report the case of a 51-year-old man who presented with clinical and laboratory findings compatible with EAS. CT scan revealed a lesion of uncertain nature at the lower pole of the left kidney. Octreotide scan found a filling defect at the lower pole of left kidney. It was difficult to determine if this finding was the true etiology or an incidental finding. Unfortunately, the patient’s clinical status rapidly deteriorated with limited medical treatment. The patient underwent left nephrectomy and left adrenalectomy. Histopathological examination confirmed NET with oncocytic features. Immunohistochemistry staining was positive for ACTH. The patient’s condition gradually improved. Additionally, glucocorticoid replacement was required only 6 months during a gradual recovery of hypothalamic pituitary adrenal axis achieved approximately three years after tumor removal. Although extremely rare, primary renal NET should be considered as a cause of EAS particularly in a patient with rapid clinical deterioration. Thorough investigation, early diagnosis and careful management are crucial to reduce morbidity and mortality.

Learning points

Primary renal NET is an extremely rare cause of ectopic ACTH syndrome.

Ectopic ACTH syndrome has a rapid onset with severe clinical manifestations. In this case, the patient’s condition deteriorated rapidly, resulting from severe hypercortisolism. Resection of the tumor is the most effective treatment.

Localization of ectopic ACTH-secreting tumors is very challenging. Multimodality imaging including CT, MRI, octreotide scan, and positron emission tomography plays a crucial role in identifying the tumors. However, each imaging modality has limitations.
On-chip environmentally assisted cracking in thin freestanding SiO2 films
Authors: Jaddi Sahar , Raskin Jean-Pierre , Pardoen Thomas 
Published: April 2021

Abstract
An on-chip fracture mechanics method is extended to characterize subcritical crack growth in submicron freestanding films. The method relies on a self-actuated concept based on MEMS fabrication principles. The configuration consists of a notched specimen attached to actuator beams involving high internal stress. Upon release, a crack initiates at the notch, propagates, and arrests. Several improvements are worked out to limit the mode III component and to avoid crack kinking. The method is applied to subcritical crack growth in 140-nm-thick SiO2 films under different humidity conditions. The data reduction scheme relates crack growth rate to stress intensity factor. The static fracture toughness value is ~ 0.73 MPa $$\sqrt{\mathrm{m}}$$

m

, with standard error of 0.01 MPa $$\sqrt{\mathrm{m}}$$

m

and standard deviation of 0.17 MPa $$\sqrt{\mathrm{m}}.$$

m

.

Subcritical crack growth rates are much smaller than in bulk specimens. A major advantage is that many test samples can be simultaneously monitored while avoiding any external equipment.

Graphic Abstract