bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benjamin Franklin and the Reasonableness of Christianity
Authors: Slack Kevin 
Published: July 2021

AbstractWhile much has been written on Benjamin Franklin's view of religion, less has been written on his Christian theology. This article first situates Franklin as an important figure in the religious Enlightenment, connecting his own view of philosophy to his teachings on Christian revelation. Providing historical context on the subscription debates, it then gives a comprehensive treatment of Franklin's Christian theology in the 1735 Hemphill affair. New scholarship on Franklin's transatlantic sources confirms that, far from attempting to undermine Christianity, he appealed to popular European writers in an attempt to bend it to reasonable ends. Moreover, Franklin's own views on church polity and liturgy developed over time. As he rose from a middling artisan to political power, he saw both the need for religious appeals and the threat that competing sects posed to political unity. His focus shifted from religious freedoms in private associations to institutionalizing elements of Christian teachings in education, charity, commerce, and defense. His experiences with rigid Presbyterian orthodoxy and chaotic New Light enthusiasm also awakened him to the need for more reasonable forms of worship, and he set to the task of experimenting with Christian liturgies to achieve both the tranquility of parishioners’ minds and social unity.
It’s Time to Talk to Prehospital Providers: Feedback Disparities among Ground-Based Emergency Medical Services Providers and its Impact on Job Satisfaction
Authors: McGuire Sarayna S. , Luke Anuradha , Klassen Aaron B. , Myers Lucas A. , Mullan Aidan F. , Sztajnkrycer Matthew D. 
Published: July 2021

AbstractObjective:Performance feedback on clinical care and patient outcomes is a cornerstone of medical education, yet it remains lacking in the prehospital environment. Research seeking to establish the quantity of feedback provided to Emergency Medical Services (EMS) has been limited and studies focused on complimentary feedback or how feedback relates to EMS job satisfaction are lacking. The objectives of this study were to measure the frequency and nature of feedback received by EMS agencies and to identify the importance of receiving feedback as it relates to EMS job satisfaction.Methods:This was an anonymous, survey-based study of twenty-nine Basic Life Support (BLS) and fifteen Advanced Life Support (ALS) agencies located in Southeastern Minnesota (USA). Descriptive statistics and Fisher exact tests were used. The study was deemed exempt by the Mayo Clinic Institutional Review Board.Results:Ninety-four responses were included from nineteen different EMS agencies, including sixty-one (64.9%) paramedics and thirty-three (35.1%) emergency medical technicians (EMTs). One-half of all respondents reported that they had not received any type of feedback in the past 30 days, while another 43.6% of respondents indicated that they had only received feedback one to three times in the same time period. Twenty (60.6%) EMTs reported receiving no feedback in the past 30 days, compared with twenty-seven (44.3%) paramedics (P = .123). Of respondents receiving feedback, 65.9% reported never or rarely receiving positive reinforcing feedback and 60.6% reported never or rarely receiving constructive criticism or feedback regarding something that did not go well with patient care or transport. The majority of respondents were dissatisfied with the quantity (86.1%) and quality (73.4%) of feedback received. An overwhelming majority (93.6%) indicated that feedback on patient care or outcomes was important in influencing their overall job satisfaction. This high importance was maintained across all demographic groups.Conclusion:Within the cohort of survey respondents, a paucity of feedback received by EMS personnel is a source of dissatisfaction for EMS providers. Feedback on patient care strongly relates to overall job satisfaction. These findings suggest system-wide opportunities for structured feedback processes, focusing upon both quality and quantity of delivered feedback, to improve both patient care and staff satisfaction.
Improve the Performance of the Noah‐MP‐Crop Model by Jointly Assimilating Soil Moisture and Vegetation Phenology Data
Authors: Xu Tongren , Chen Fei , He Xinlei , Barlage Michael , Zhang Zhe , Liu Shaomin , He Xiangping 
Published: July 2021

AbstractThe interactions between crops and the atmosphere significantly impact surface energy and hydrology budgets, climate, crop yield, and agricultural management. In this study, a multipass land data assimilation scheme (MLDAS) is proposed based on the Noah‐MP‐Crop model. The ensemble Kalman filter (EnKF) method is used to jointly assimilate the leaf area index (LAI), soil moisture (SM), and solar‐induced chlorophyll fluorescence (SIF) observations to predict sensible (H) and latent (LE) heat fluxes, gross primary productivity (GPP), etc. Such joint assimilation is demonstrated to be effective in constraining the model state variables (i.e., leaf biomass and SM) and optimizing key crop‐model parameters (i.e., specific leaf area [SLA], and maximum rate of carboxylation, Vcmax). The performance of the MLDAS is evaluated against observations at two AmeriFlux cropland sites, revealing good an agreement with the observed H, LE, and GPP. When using optimized model parameters (SLA and Vcmax) and jointly assimilating LAI, SM, and SIF observations, the MLDAS produces 34.28%, 26.90%, and 51.82% lower root mean square deviations for daily H, LE, and GPP estimates compared with the Noah‐MP‐Crop open loop simulation. Our findings also indicate that the H and LE predictions are more sensitive to SM measurements, while the GPP simulations are more affected by LAI and SIF observations. The results indicate that performances of physical models can be greatly improved by assimilating multi‐source observations within MLDAS.
Frictional Melting in Hydrothermal Fluid‐Rich Faults: Field and Experimental Evidence From the Bolfín Fault Zone (Chile)
Authors: Gomila R. , Fondriest M. , Jensen E. , Spagnuolo E. , Masoch S. , Mitchell T. M. , Magnarini G. , Bistacchi A. , Mittempergher S. , Faulkner D. , Cembrano J. , Di Toro G. 
Published: July 2021

AbstractTectonic pseudotachylytes are thought to be unique to certain water‐deficient seismogenic environments and their presence is considered to be rare in the geological record. Here, we present field and experimental evidence that frictional melting can occur in hydrothermal fluid‐rich faults hosted in the continental crust. Pseudotachylytes were found in the >40 km‐long Bolfín Fault Zone of the Atacama Fault System, within two ca. 1 m‐thick (ultra)cataclastic strands hosted in a damage‐zone made of chlorite‐epidote‐rich hydrothermally altered tonalite. This alteration state indicates that hydrothermal fluids were active during the fault development. Pseudotachylytes, characterized by presenting amygdales, cut and are cut by chlorite‐, epidote‐ and calcite‐bearing veins. In turn, crosscutting relationship with the hydrothermal veins indicates pseudotachylytes were formed during this period of fluid activity. Rotary shear experiments conducted on bare surfaces of hydrothermally altered rocks at seismic slip velocities (3 m s−1) resulted in the production of vesiculated pseudotachylytes both at dry and water‐pressurized conditions, with melt lubrication as the primary mechanism for fault dynamic weakening. The presented evidence challenges the common hypothesis that pseudotachylytes are limited to fluid‐deficient environments, and gives insights into the ancient seismic activity of the system. Both field observations and experimental evidence, indicate that pseudotachylytes may easily be produced in hydrothermal environments, and could be a common co‐seismic fault product. Consequently, melt lubrication could be considered one of the most efficient seismic dynamic weakening mechanisms in crystalline basement rocks of the continental crust.
Orbital‐ and Millennial‐Scale Changes in Lake‐Levels Facilitate Earthquake‐Triggered Mass Failures in the Dead Sea Basin
Authors: Lu Yin , Moernaut Jasper , Waldmann Nicolas , Bookman Revital , Ian Alsop G. , Hubert‐Ferrari Aurélia , Strasser Michael , Agnon Amotz , Marco Shmuel 
Published: July 2021

AbstractThe possible link between the occurrence of submarine mass failure and climate‐driven factors is highly disputed. This is due largely to the lack of comprehensive records of mass failures in the geologic record for which ages, triggers, and preconditioning factors can be reliably constrained. Such controls would allow accurate testing of cause‐and‐effect relationships. We present a record that comprises 490 earthquake‐triggered mass failure deposits from the Dead Sea depocenter over the past 220 kyr that permits a robust statistical evaluation and correlation with potential preconditioning factors. Our data set reveals that (a) at the orbital‐ and millennial‐scale, variable sedimentation rates are not a preconditioning factor for these mass failure deposits; (b) at the centennial‐to decadal‐scale, earthquake‐triggered mass failures can occur at any lake‐level state; (c) at the orbital‐ and millennial‐scale, the mass failures are more frequent when lake‐levels were high and punctuated by large‐amplitude fluctuations.
Exhumation History Along the Muli Thrust—Implication for Crustal Thickening Mechanism in Eastern Tibet
Authors: Pitard P. , Replumaz A. , Chevalier M.‐L. , Leloup P.‐H. , Bai M. , Doin M.‐P. , Thieulot C. , Ou X. , Balvay M. , Li H. 
Published: July 2021

AbstractThrusting implication in the crustal thickening history of eastern Tibet is highly debated. The ∼250 km‐long Muli thrust of the Yalong thrust belt in SE Tibet is a major Miocene structure with a pronounced topographic step (∼2,000 m). Using thermo‐kinematic modeling based on thermochronology data, we constrain the crustal geometry of the thrust as being steep (>70°) at the surface, in agreement with field observations, and flattening at depth (≥20 km) on an intra‐crustal décollement. Thrusting motion on the fault shows a velocity of 0.2 ± 0.06 km/Ma since 50 Ma, followed by an acceleration at a rate of 0.6 ± 0.08 km/Ma starting at 12.5 ± 1 Ma, yielding a total of ∼15 km of exhumed crust. Deeper, deformation may be localized through a ductile shear zone, and be related to the ∼15 km Moho step and shear wave velocity contrast imaged by tomography beneath the Yalong thrust belt.
Statistics of Magnetosonic Waves in the Slot Region Observed by Van Allen Probes
Authors: Yan Ling , Cao Xing , Hua Man , Ni Binbin , Zhang Yuannong 
Published: July 2021

AbstractWe perform a statistical analysis of magnetosonic (MS) waves in the slot region based on Van Allen Probes observations from September 2012 to February 2018. Our results demonstrate that the wave occurrence rate increases with enhanced geomagnetic activity and decreasing magnetic latitude, with the presence of strongest slot region MS waves near the geomagnetic equator within the 08–20 magnetic local time sector. Power spectral densities of slot region MS waves also intensify during geomagnetically active times, with the occurrence of the major wave power (>∼10−5 nT2/Hz) below ∼25fcp (where fcp is the proton gyrofrequency) and the peak wave intensity (∼10−3 nT2/Hz) below ∼5fcp at L > ∼2.6. A remarkable gap in the MS wave frequency spectrum is also revealed at <∼15fcp during weak substorm activities (AE 300 nT).
Ionospheric Response to the December 14, 2020 Total Solar Eclipse in South America
Authors: Gómez Demián D. 
Published: July 2021

AbstractThe Southern Andes, in Patagonia, are a well‐known hotspot of orographic gravity waves (oGWs) during winter when atmospheric conditions, such as temperature, wind speed, and wind direction, favor their generation and propagation. In the summer, oGWs above the mesosphere and oGW‐induced ionospheric perturbations are rarely observed because vertical wave propagation conditions are unfavorable. Nevertheless, when atmospheric conditions deviate significantly from those typical of summer, for example, during a solar eclipse (SE), the atmospheric temperature and wind changes can allow oGWs to reach ionospheric heights. Global Navigation Satellite Systems (GNSS)‐based ionospheric total electron content (TEC) studies of the 2017 North American eclipse showed oGW‐compatible observations near the totality zone around the Rocky Mountains, and it was suggested, but not shown, that these were likely oGWs. In this work, we report, model, and interpret GNSS TEC perturbations observed during the December 14, 2020 total SE in South America. TEC data recorded near the Andes during this total SE are in good agreement with predictions by the SAMI3 ionospheric model until shortly after the passage of the umbra. TEC data after totality can best be explained with the interpretation that the observation of oGWs was favored by the passage of the eclipse over the Andes Mountains.
Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization
Authors: Sha Zhiqiang , Schijven Dick , Francks Clyde 
Published: July 2021

AbstractAutism spectrum disorder (ASD) and schizophrenia have been conceived as partly opposing disorders in terms of systemizing vs. empathizing cognitive styles, with resemblances to male vs. female average sex differences. Left–right asymmetry of the brain is an important aspect of its organization that shows average differences between the sexes and can be altered in both ASD and schizophrenia. Here we mapped multivariate associations of polygenic risk scores for ASD and schizophrenia with asymmetries of regional cerebral cortical surface area, thickness, and subcortical volume measures in 32,256 participants from the UK Biobank. Polygenic risks for the two disorders were positively correlated (r = 0.08, p = 7.13 × 10−50) and both were higher in females compared to males, consistent with biased participation against higher-risk males. Each polygenic risk score was associated with multivariate brain asymmetry after adjusting for sex, ASD r = 0.03, p = 2.17 × 10−9, and schizophrenia r = 0.04, p = 2.61 × 10−11, but the multivariate patterns were mostly distinct for the two polygenic risks and neither resembled average sex differences. Annotation based on meta-analyzed functional imaging data showed that both polygenic risks were associated with asymmetries of regions important for language and executive functions, consistent with behavioral associations that arose in phenome-wide association analysis. Overall, the results indicate that distinct patterns of subtly altered brain asymmetry may be functionally relevant manifestations of polygenic risks for ASD and schizophrenia, but do not support brain masculinization or feminization in their etiologies.
Sugars promote graft union development in the heterograft of cucumber onto pumpkin
Authors: Miao Li , Li Qing , Sun Tian-shu , Chai Sen , Wang Changlin , Bai Longqiang , Sun Mintao , Li Yansu , Qin Xing , Zhang Zhonghua , Yu Xianchang 
Published: July 2021

AbstractThe use of heterografts is widely applied for the production of several important commercial crops, but the molecular mechanism of graft union formation remains poorly understood. Here, cucumber grafted onto pumpkin was used to study graft union development, and genome-wide tempo-spatial gene expression at the graft interface was comprehensively investigated. Histological analysis suggested that resumption of the rootstock growth occurred after both phloem and xylem reconnection, and the scion showed evident callus production compared with the rootstock 3 days after grafting. Consistently, transcriptome data revealed specific responses between the scion and rootstock in the expression of genes related to cambium development, the cell cycle, and sugar metabolism during both vascular reconnection and healing, indicating distinct mechanisms. Additionally, lower levels of sugars and significantly changed sugar enzyme activities at the graft junction were observed during vascular reconnection. Next, we found that the healing process of grafted etiolated seedlings was significantly delayed, and graft success, xylem reconnection, and the growth of grafted plants were enhanced by exogenous glucose. This demonstrates that graft union formation requires the correct sugar content. Furthermore, we also found that graft union formation was delayed with a lower energy charge by the target of rapamycin (TOR) inhibitor AZD-8055, and xylem reconnection and the growth of grafted plants were enhanced under AZD-8055 with exogenous glucose treatment. Taken together, our results reveal that sugars play a positive role in graft union formation by promoting the growth of cucumber/pumpkin and provide useful information for understanding graft union healing and the application of heterografting in the future.
Sexual competition and kin recognition co-shape the traits of neighboring dioecious Diospyros morrisiana seedlings
Authors: He Yulin , Xu Han , Liu Hanlun , Luo Meiling , Chu Chengjin , Fang Suqin 
Published: July 2021

AbstractPlants respond differently to the identity of their neighbors, such as their sex and kinship, showing plasticity in their traits. However, how the functional traits of dioecious trees are shaped by the recognition of neighbors with different sex and kinship remains unknown. In this study, we set up an experiment with different kin/nonkin and inter/intrasexual combinations for a dioecious tree species, Diospyros morrisiana. The results showed that plants grew better with nonkin and intrasexual neighbors than with kin and intersexual neighbors. Kin combinations had significantly shorter root length in the resource-overlapping zone than nonkin combinations, suggesting that kin tended to reduce competition by adjusting their root distribution, especially among female siblings. Our study suggested that the seedling growth of D. morrisiana was affected by both the relatedness and sexual identity of neighboring plants. Further analysis by gas chromatography-mass spectrometry showed that the root exudate composition of female seedlings differed from that of male seedlings. Root exudates may play important roles in sex competition in dioecious plants. This study indicates that sex-specific competition and kin recognition interact and co-shape the traits of D. morrisiana seedlings, while intrasexual and nonkin neighbors facilitate the growth of seedlings. Our study implies that kin- and sex-related interactions depend on different mechanisms, kin selection, and niche partitioning, respectively. These results are critical for understanding how species coexist and how traits are shaped in nature.
Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant
Authors: Ilmjärv Sten , Abdul Fabien , Acosta-Gutiérrez Silvia , Estarellas Carolina , Galdadas Ioannis , Casimir Marina , Alessandrini Marco , Gervasio Francesco Luigi , Krause Karl-Heinz 
Published: July 2021

AbstractThe D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we confirmed that the aspartate replacement by glycine in position 614 is markedly more infectious. Molecular modelling suggests that the G614 mutation facilitates transition towards an open state of the Spike protein. To explain the epidemiological success of D614G, we analysed the evolution of 27,086 high-quality SARS-CoV-2 genome sequences from GISAID. We observed striking coevolution of D614G with the P323L mutation in the viral polymerase. Importantly, the exclusive presence of G614 or L323 did not become epidemiologically relevant. In contrast, the combination of the two mutations gave rise to a viral G/L variant that has all but replaced the initial D/P variant. Our results suggest that the P323L mutation, located in the interface domain of the RNA-dependent RNA polymerase, is a necessary alteration that led to the epidemiological success of the present variant of SARS-CoV-2. However, we did not observe a significant correlation between reported COVID-19 mortality in different countries and the prevalence of the Wuhan versus G/L variant. Nevertheless, when comparing the speed of emergence and the ultimate predominance in individual countries, it is clear that the G/L variant displays major epidemiological supremacy over the original variant.
Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice
Authors: Iida Masataka , Desamero Mark Joseph , Yasuda Kosuke , Nakashima Ayaka , Suzuki Kengo , Chambers James Ken , Uchida Kazuyuki , Ogawa Ryohei , Hachimura Satoshi , Nakayama Jun , Kyuwa Shigeru , Miura Kozue , Kakuta Shigeru , Hirayama Kazuhiro 
Published: July 2021

AbstractEuglena gracilis is widely utilized as food or supplement to promote human and animal health, as it contains rich nutrients. In this study, we administered spray-dried powder of E. gracilis and paramylon, β-glucan stored in E. gracilis cells, to A4gnt knockout (KO) mice. A4gnt KO mice are a mutant mouse model that spontaneously develops gastric cancer through hyperplasia-dysplasia-adenocarcinoma sequence in the antrum of the stomach, and we observed the effects of E. gracilis and paramylon on the early involvements of A4gnt KO mice. Male and female 10-week-old A4gnt KO mice and their age-matched wildtype C57BL/6J mice were orally administered with 50 mg of E. gracilis or paramylon suspended in saline or saline as a control. After 3-week administration, animals were euthanatized and the stomach was examined histopathologically and immunohistochemically. Gene expression patterns of the stomach, which have been reported to be altered with A4gnt KO, and IgA concentration in small intestine were also analyzed with real-time PCR and ELISA, respectively. Administration of Euglena significantly reduced the number of stimulated CD3-positive T-lymphocytes in pyloric mucosa of A4gnt KO mice and tend to reduce polymorphonuclear leukocytes infiltration. Euglena administration further downregulated the expression of Il11 and Cxcl1 of A4gnt KO mice. Euglena administration also affected IgA concentration in small intestinal contents of A4gnt KO mice. Paramylon administration reduced the number of CD3-positive lymphocytes in pyloric mucosa of A4gnt KO mice, and downregulated the expressions of Il11 and Ccl2 of A4gnt KO mice. Although we found no significant effects on gross and microscopic signs of gastric dysplasia and cell proliferation, the present study suggests that the administration of Euglena and paramylon may ameliorate the early involvements of A4gnt mice through the effects on inflammatory reactions in the gastric mucosa. The cancer-preventing effects should be studied with long-term experiments until actual gastric cancer formation.