bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fractional optimal control of COVID-19 pandemic model with generalized Mittag-Leffler function
Authors: Khan Amir , Zarin Rahat , Humphries Usa Wannasingha , Akgül Ali , Saeed Anwar , Gul Taza 
Published: August 2021

AbstractIn this paper, we consider a fractional COVID-19 epidemic model with a convex incidence rate. The Atangana–Baleanu fractional operator in the Caputo sense is taken into account. We establish the equilibrium points, basic reproduction number, and local stability at both the equilibrium points. The existence and uniqueness of the solution are proved by using Banach and Leray–Schauder alternative type theorems. For the fractional numerical simulations, we use the Toufik–Atangana scheme. Optimal control analysis is carried out to minimize the infection and maximize the susceptible people.
Multi-isotope signatures (Cu, Zn, Pb) of different particle sizes in road-deposited sediments: a case study from industrial area
Authors: Jeong Hyeryeong , Ra Kongtae 
Published: August 2021

AbstractRoad-deposited sediments (RDS) are major sources of heavy metal contamination in urban areas and adversely affect surrounding environments and human health. Multi-isotope combinations (Cu, Zn, and Pb), which serve as environmental tracers, enable the identification and management of metal contaminants in RDS. Here, we present Cu, Zn, and Pb isotopic data for the first time in size-fractionated RDS samples collected from industrial areas to describe the relationship between the RDS and total suspended solids (TSS) in runoff, and to explore the feasibility of using multi-isotopes to identify sources of metal contamination. RDS in the industrial study areas had high concentrations of Cu, Zn, and Pb, and their δ65CuAE647, δ66ZnIRMM3702, and 206Pb/207Pb values ranged from − 0.33 to + 0.73‰, − 0.36 to + 0.01‰, and 1.1418 to 1.1616, respectively. The variation in δ65CuAE647 (δ65Cumax-min) was larger than that of δ66ZnIRMM3702 (i.e., δ66Znmax-min), and the isotope values of Zn and Pb (206Pb/207Pb) tended to increase with the concentrations of these elements. Meanwhile, the fine RDS particles (< 63 µm) had similar Cu, Zn, and Pb isotopic compositions to those of TSS. Hierarchical cluster analyses revealed that the < 63 µm RDS fractions were associated with the TSS. Our results also showed that a combination of Pb and either Cu or Zn could be used to distinguish between RDS and non-exhaust emissions (e.g., brake pads, tires, etc.). Multi-isotope approaches utilizing Cu, Zn, and Pb and more robust isotopic data on individual sources of metal contamination could be useful for identifying pollution sources and understanding their environmental impacts.
Orthobiologics and hyaluronic acid usage in the Netherlands: an electronic survey of 265 orthopaedic surgeons and sports physicians
Authors: de Graeff J. J. , van den Bekerom M. P. J. , van Meer B. L. , Zijl J. A. C. ,   On behalf of the Dutch Arthroscopy Society
Published: August 2021

Abstract
Purpose
“Biologic therapies” in the field of orthopaedic surgery and sports medicine, so called orthobiologics, have been gaining significant interest from physicians and patients, with increasing usage over the recent years. The aim of this study is to (1) evaluate the usage of orthobiologics in the Netherlands, (2) to clarify the reasons for the use or non-use of orthobiologics, and (3) the most addressed disease for use of orthobiologics.

Methods
The authors created a 19-quenstion online survey comprised of both closed-ended and open-ended response questions in order to examine the use of and the indication for orthobiologics. The survey was sent to all the members of the Dutch Orthopaedic Association and Netherlands Association of Sports Medicine of which 15% responded.

Results
The majority of the 265 respondents (65%) did not treat patients with or refer patients for treatment with orthobiologics. The most important reasons for not using orthobiologics were the lack of scientific evidence, the lack of good experience, and the lack of insurance coverage. Of the physicians that used orthobiologics, the most used hyaluronic acid (76%) and platelet-rich plasma (27%). Orthobiologics were most used for knee osteoarthritis and medial or lateral epicondylitis.

Conclusion
Although some orthobiologic treatments might be effective and the research interest is growing, our study shows that the majority of orthopaedic and sport physician clinicians in the Netherlands still does not make use of orthobiologics as a treatment option, but almost a third of them is contemplating to start using orthobiologics.

Level of evidence
III.
Laparoscopic resection of schwannoma in the hepatoduodenal ligament: a case report
Authors: Bekki Tomoaki , Oishi Koichi , Tadokoro Takeshi , Namba Yosuke , Okimoto Sho , Mukai Shoichiro , Saito Yasufumi , Fujisaki Seiji , Nishida Toshihiro , Ohdan Hideki , Fukuda Toshikatsu 
Published: August 2021

Abstract
Background
The occurrence of schwannomas in the hepatoduodenal ligament is rare, and its preoperative accurate diagnosis is difficult. Only few cases have been treated with laparoscopic surgery.

Case presentation
A 54-year-old man visited our hospital following abnormal abdominal computed tomography findings. He had no complaints, and his laboratory investigations were normal. Abdominal contrast-enhanced computed tomography revealed a tumor with enhancement at the margin of the hepatoduodenal ligament. The abdominal magnetic resonance imaging findings of the tumor showed hypointensity on the T1-weighted images and mixed hypointensity and hyperintensity on the T2-weighted fat-suppression images. Positron emission tomography showed localized accumulation of fludeoxyglucose only in the hepatoduodenal ligament tumor. The patient underwent laparoscopic tumor resection for accurate diagnosis. Histopathologically, the tumor was mainly composed of spindle cells, which were strongly positive for S-100 protein on immunohistochemical staining. The patient was discharged without any postoperative complications on day 5.

Conclusions
Complete tumor resection is essential for schwannomas to avoid recurrence. Laparoscopic surgery is useful for schwannomas occurring in the hepatoduodenal ligament and can be performed safely by devising an appropriate surgical method.
Radiating pain during epidural needle insertion and catheter placement cannot be associated with postoperative persistent paresthesia: a retrospective review
Authors: Kotani Taichi , Inoue Satoki , Uemura Keiko , Kawaguchi Masahiko 
Published: August 2021

Abstract
Background
It has been suggested that radiating pain during spinal or epidural needle insertion and catheter placement can be an indicator of needle-related nerve injury. In this study, using a historical cohort, we investigated what factors could be associated with postoperative persistent paresthesia. In addition, we focused on radiating pain during epidural needle insertion and catheterization.

Methods
This was a retrospective review of an institutional registry containing 21,606 anesthesia cases. We conducted multivariate logistic analysis in 2736 patients, who underwent epidural anesthesia, using the incidence of postoperative persistent paresthesia as a dependent variable and other covariates, including items of the anesthesia registry and the postoperative questionnaire, as independent variables in order to investigate the factors that were significantly associated with the risk of persistent paresthesia.

Results
One hundred and seventy-six patients (6.44%) were found to have persistent paresthesia. Multivariate analysis revealed that surgical site at the extremities (odds ratio (OR), 12.5; 95% confidence interval (CI), 2.77–56.4; the reference was set at abdominal surgery), duration of general anesthesia (per 10 min) (OR, 1.02; 95% CI, 1.01–1.03), postoperative headache (OR, 1.78; 95% CI, 1.04–2.95), and days taken to visit the consultation clinic (OR, 1.03; 95% CI, 1.01–1.06) were independently associated with persistent paresthesia. Radiating pain was not significantly associated with persistent paresthesia (OR, 1.56; 95% CI, 0.69–3.54).

Conclusion
Radiating pain during epidural procedure was not statistically significantly associated with persistent paresthesia, which may imply that this radiating pain worked as a warning of nerve injury.
Innovative design of 3D-printed nasopharyngeal pediatric swab for COVID-19 detection
Authors: Alazemi Ameerah , AbdulHussain Ghadeer , Alawwam Abdullah , Al-Shatti Ali , Alghounaim Mohammad , Almazeedi Sulaiman , Al Youha Sarah , Al-Sabah Salman 
Published: August 2021

Abstract3-dimensional (3D) printing technology provides a solution to meet the high demand for producing adult nasal swabs. A smaller, more flexible nasopharyngeal swab needs to be developed for children and infants suspected of having coronavirus. The information shared here presents a novel 3D-printed pediatric swab for the purpose of collecting upper respiratory clinical specimens.
Association of severe mental illness with stroke outcomes and process-of-care quality indicators: nationwide cohort study
Authors: Fleetwood Kelly , Wild Sarah H. , Smith Daniel J. , Mercer Stewart W. , Licence Kirsty , Sudlow Cathie L. M. , Jackson Caroline A. 
Published: August 2021

BackgroundSevere mental illness (SMI) is associated with increased stroke risk, but little is known about how SMI relates to stroke prognosis and receipt of acute care.AimsTo determine the association between SMI and stroke outcomes and receipt of process-of-care quality indicators (such as timely admission to stroke unit).MethodWe conducted a cohort study using routinely collected linked data-sets, including adults with a first hospital admission for stroke in Scotland during 1991–2014, with process-of-care quality indicator data available from 2010. We identified pre-existing schizophrenia, bipolar disorder and major depression from hospital records. We used logistic regression to evaluate 30-day, 1-year and 5-year mortality and receipt of process-of-care quality indicators by pre-existing SMI, adjusting for sociodemographic and clinical factors. We used Cox regression to evaluate further stroke and vascular events (stroke and myocardial infarction).ResultsAmong 228 699 patients who had had a stroke, 1186 (0.5%), 859 (0.4%), 7308 (3.2%) had schizophrenia, bipolar disorder and major depression, respectively. Overall, median follow-up was 2.6 years. Compared with adults without a record of mental illness, 30-day mortality was higher for schizophrenia (adjusted odds ratio (aOR) = 1.33, 95% CI 1.16–1.52), bipolar disorder (aOR = 1.37, 95% CI 1.18–1.60) and major depression (aOR = 1.11, 95% CI 1.05–1.18). Each disorder was also associated with marked increased risk of 1-year and 5-year mortality and further stroke and vascular events. There were no clear differences in receipt of process-of-care quality indicators.ConclusionsPre-existing SMI was associated with higher risks of mortality and further vascular events. Urgent action is needed to better understand and address the reasons for these disparities.
Next-Generation Sequencing of Patients With Breast Cancer in Community Oncology Clinics
Authors: Sturgill Emma G. , Misch Amanda , Lachs Rebecca , Jones Carissa C. , Schlauch Dan , Jones Suzanne F. , Shastry Mythili , Yardley Denise A. , Burris Howard A. , Spigel David R. , Hamilton Erika P. , McKenzie Andrew J. 
Published: August 2021

PURPOSEMolecular biomarkers informing disease diagnosis, prognosis, and treatment decisions in patients with breast cancer are being uncovered by next-generation sequencing (NGS) technologies. In this study, we survey how NGS is used for patients with breast cancer in real-world settings with a focus on physician behaviors and sequencing results.METHODSWe conducted a retrospective analysis of patients with breast cancer who received NGS testing from commercial vendors as part of standard of care from 2014 to 2019. A total of 2,635 NGS reports from 2,316 unique breast cancer patients were assessed. Hormone receptor and human epidermal growth factor receptor 2 statuses were abstracted from patient medical records. Comparative gene amplification and mutation frequencies were analyzed using Pearson's correlation and Lin's concordance statistics.RESULTSThe number of physicians ordering NGS tests for patients with breast cancer increased more than six-fold from 2014 to 2019. Tissue- and plasma-based tests were ordered roughly equally by 2019, with plasma-based testing ordered most frequently in hormone receptor–positive subtypes. Patients with triple-negative breast cancer were most likely to receive NGS testing. Gene amplifications including ERBB2 were detected less frequently in our real-world data set as compared to previous genomic landscape studies, whereas the opposite was true for gene mutations including ESR1. Pathogenic mutations in the PI3K pathway (38.6%) and DNA damage repair pathway (11.0%) were frequently reported. Alterations were also reported across other cellular pathways.CONCLUSIONOverall, we found that an increasing number of physicians in community settings are adopting NGS in the care of patients with breast cancer. Discrepancies between our real-world NGS data and previous genomic landscape studies are likely owed to the prevalence of plasma-based testing in community oncology clinics, as the reference data were from tissue-based NGS alone.
Breast Cancer Endocrine Therapy Promotes Weight Gain With Distinct Adipose Tissue Effects in Lean and Obese Female Mice
Authors: Scalzo Rebecca L , Foright Rebecca M , Hull Sara E , Knaub Leslie A , Johnson-Murguia Stevi , Kinanee Fotobari , Kaplan Jeffrey , Houck Julie A , Johnson Ginger , Sharp Rachel R , Gillen Austin E , Jones Kenneth L , Zhang Anni M Y , Johnson James D , MacLean Paul S , Reusch Jane E B , Wright-Hobart Sabrina , Wellberg Elizabeth A 
Published: August 2021

Abstract
Breast cancer survivors treated with tamoxifen and aromatase inhibitors report weight gain and have an elevated risk of type 2 diabetes, especially if they have obesity. These patient experiences are inconsistent with, preclinical studies using high doses of tamoxifen which reported acute weight loss. We investigated the impact of breast cancer endocrine therapies in a preclinical model of obesity and in a small group of breast adipose tissue samples from women taking tamoxifen to understand the clinical findings. Mature female mice were housed at thermoneutrality and fed either a low-fat/low-sucrose (LFLS) or a high-fat/high-sucrose (HFHS) diet. Consistent with the high expression of Esr1 observed in mesenchymal stem cells from adipose tissue, endocrine therapy was associated with adipose accumulation and more preadipocytes compared with estrogen-treated control mice but resulted in fewer adipocyte progenitors only in the context of HFHS. Analysis of subcutaneous adipose stromal cells revealed diet- and treatment-dependent effects of endocrine therapies on various cell types and genes, illustrating the complexity of adipose tissue estrogen receptor signaling. Breast cancer therapies supported adipocyte hypertrophy and associated with hepatic steatosis, hyperinsulinemia, and glucose intolerance, particularly in obese females. Current tamoxifen use associated with larger breast adipocyte diameter only in women with obesity. Our translational studies suggest that endocrine therapies may disrupt adipocyte progenitors and support adipocyte hypertrophy, potentially leading to ectopic lipid deposition that may be linked to a greater type 2 diabetes risk. Monitoring glucose tolerance and potential interventions that target insulin action should be considered for some women receiving life-saving endocrine therapies for breast cancer.
Online Dating Is Shifting Educational Inequalities in Marriage Formation in Germany
Authors: Potarca Gina 
Published: August 2021

AbstractDigital technologies govern a large part of our social lives, including the pursuit of a romantic partner. Despite recent inquiries into the social consequences of meeting online, what remains unclear is how the link between education and union formation varies in online versus offline meeting contexts, particularly on the backdrop of growing educational gaps in marriage. Using 2008–2019 pairfam data from Germany (N = 3,561), this study ran a series of Fine-Gray competing risks models to assess how online dating shapes the transition to marriage for partnered adults with nontertiary and tertiary education. Results reveal that irrespective of education, men in online-formed couples had greater chances of marrying than men in couples established offline. Highly educated women who met their partner in nondigital ways were less prone to marry than lower-educated women; for women in couples initiated online, however, the pattern was reversed. The internet dating marriage advantage of well-educated women was partly related to better matching on marriage attitudes and gender ideology. Facing a scarcity of eligible partners offline, high-educated women draw on more abundant online options to select more egalitarian-minded men. This study overall suggests that internet dating fosters an uneven distribution of opportunities for marriage, highlighting the role of digital partner markets in the social demography of union formation.
Nucleoporin 50 mediates Kcna4 transcription to regulate cardiac electrical activity
Authors: Gao Xueting , Yu Shuai , Guan Yi , Shen Yunli , Xu Liang 
Published: August 2021

ABSTRACT
Emerging evidence has demonstrated that nucleoporins (Nups) play a pivotal role in cell-type-specific gene regulation, but how they control the expression and activity of ion channel genes in the heart remains unclear. Here, we show that Nup50, which is localized in the nucleus of cardiomyocytes, selectively induces an increase in the transcription and translation of Kcna4. The Kcna4 gene encodes a K+ voltage-gated channel of shaker-related subfamily member 4 and is essential for regulating the action potential in cardiac membranes. Using immunofluorescence imaging, luciferase assays and chromatin immunoprecipitation assays, we identified that the direct binding of the FG-repeat domain within Nup50 to the proximity of the Kcna4 promoter was required to activate the transcription and subsequent translation of Kcna4. Functionally, Nup50 overexpression increased the currents of KCNA4-encoded Ito,s channels, and reverse knockdown of Nup50 resulted in a remarkable decrease in the amplitude of Ito,s currents in cardiomyocytes. Moreover, a positive correlation between Nup50 and Kcna4 mRNA and protein expression was observed in heart tissues subjected to ischemic insults. These findings provide insights into the homeostatic control of cardiac electrophysiology through Nup-mediated regulation.
The impact of coronavirus disease 2019 (COVID-19) on older adults with an intellectual disability during the first wave of the pandemic in Ireland
Authors: McCarron Mary , McCausland Darren , Luus Retha , Allen Andrew , Sheerin Fintan , Burke Eilish , McGlinchy Eimear , Flannery Fidelma , McCallion Philip 
Published: August 2021

Background: People with intellectual disability have increased risk of exposure to and adverse outcomes from coronavirus disease 2019 (COVID-19).They also face challenges to mental health and well-being from COVID-19-related social restrictions and service closures. Methods: Data from a supplemental COVID-19 survey from the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA) (n=710) was used to assess outcomes from the first infection wave of COVID-19 among adults with intellectual disability aged 40+ years in Ireland. Data was gathered on testing, for symptoms and outcomes; procedures to manage COVID-19; and both stress/anxiety and positive experiences during the pandemic. Demographic and health-related data from the main IDS-TILDA dataset was included in analyses. Results: High rates were identified of health conditions associated with poorer COVID-19 outcomes, including overweight/obesity (66.6%, n=365), high cholesterol (38.6%, n=274) and cardiovascular disease (33.7%, n=239). Over half (53.5%, n=380) reported emotional, nervous or psychiatric disorders. Almost two-thirds (62.4%, n=443) were tested for COVID-19, with 10% (n=71) reporting symptoms and 2.5% (n=11) testing positive. There were no instances of COVID-19 related mortality. Common symptoms included fatigue, fever, and cough. Some participants (7.8%, n=55) moved from their usual home to isolate, most often (n=31) or relocate to a family home (n=11). Three-quarters (78.7%) of those who were symptomatic or who tested positive had plans to manage self-isolation and two-thirds were able to comply with guidelines. Over half (55%, n=383) reported some COVID-19 related stress/anxiety; and a similar proportion reported positive aspects during this period (58%, n=381). Conclusions: Our data suggests that people with intellectual disability avoided the worst impacts of COVID-19 during the first infection wave in Ireland. Nevertheless, participants’ health profiles suggest that this population remains at high risk for adverse infection outcomes. Repeated measures are needed to track health and well-being outcomes across multiple infection waves.
Escolas criativas e inclusão
Authors: Pereira Filho Adalberto Duarte , Alves Maria Dolores Fortes 
Published: August 2021

Incomodou-nos a relação da escola em que frequentavam os sujeitos da ONG que acolhia crianças e adolescentes abandonados, na qual fazíamos atendimento psicológico. A escola como um lugar onde somente as dimensões cognitivas e comportamentais eram valorizadas. Questionamos: como práticas pedagógicas criativas podem contribuir para a inclusão escolar dos sujeitos em suas múltiplas dimensões? Buscamos compreender a relação entre a criatividade e a construção de escolas inclusivas. Em um estudo de caso de natureza quanti-qualitativa. Ofertamos para 18 professores da escola que atendia os sujeitos da ONG, um curso realizado em 3 (três) encontros presenciais, intitulado “Educação em Direitos Humanos, Valores Transdisciplinares e Formação de Professoras/es”. Para coleta dos dados aplicamos em 16 cursistas, o Instrumento para Valorar o Desenvolvimento de Instituições Educativas-VADECRIE, (TORRE, 2012) Na análise, utilizamos a estatística descritiva. A partir dessa experiência compreendemos que a criatividade pode contribuir para a promoção de espaços inclusivos. Verificamos que, uma escola criativa é um lugar em constante movimento, Torre (2013). É um lugar que nos faz transcender, onde a relação empática nutre as relações humanas. Essa escola legitima o melhor de seus professores e alunos. A escola criativa rasga o véu do tradicional e convoca à inovação e, igualmente, a inclusão pois, convoca-nos a construir um espaço de pertencimento de todos.