bluuebunny/crossref_metadata_2025_split huggingface dataset:
A perfect refractory electrical storm by acute toxicity of accidental aconitine intake
Authors: Menichetti Francesca , Bartolucci Paola , Matteucci Maria Luisa , Gori Luigi , Ieri Alessandra , Gambassi Francesco , Baronti Roberto , Vanni Simone , Mannaioni Guido , Del Rosso Attilio 
Published: June 2021

A 51-years-old male presented with drooling, hematemesis and diarrhea in emergency department after accidental ingestion of homemade aconitine tincture. Examination revealed shock and initial ECG showed atrial fibrillation. The patient suddenly developed a pulseless wide QRS complex tachycardia requiring resuscitation maneuvers. The rhythm varied from monomorphic ventricular tachycardia to torsade de point to ventricular fibrillation. Repeated direct-current cardioversions were unsuccessful. After intravenous electrolyte correction and anti-arrhythmic drugs administration, a last direct-current shock was finally successful. Bradycardia and ventricular excitability persisted over 12 hours with gradual normalization. Patient was discharged in normal sinus rhythm without any medication and on follow-up he was totally asymptomatic.
With the increasing popularity of traditional medicine, clinicians should be alerted to the risk of herbal substances with low margins of safety like Aconitum in order to allow correct diagnosis and treatment. The general public should be educated that herbal medicine is not always safe.
Treatment of relapsed/refractory CLL with Venetoclax-Rituximab during the COVID-19 pandemic: A daily-life experience in southern Italy.
Authors: Molica Stefano , Sportoletti Paolo , Di Renzo Nicola , Musto Pellegrino , Pane Fabrizio , Di Raimondo Francesco 
Published: June 2021

With more than 3 million proven infections and 100.000 associated deaths in Italy, the COVID-19 pandemic poses extraordinary challenges to health-care professionals and especially to those caring for patients with haematologic malignancies (1-2). Given the multiple immune defects characterizing chronic lymphocytic leukaemia (CLL), it is considered that patients with this form of leukemia have a high-risk of suffering severe forms of COVID-19 (3-4).
Antithrombotic property of an aqueous extract from Pseudocedrela kotschyi and Adenia cissampeloides
Authors: Nyansah Wilson Bright , Koffuor George Asumeng , Ben Inemesit Okon , Gyanfosu Linda , Ehigiator Ben Enoluomen 
Published: June 2021

Background and purpose:
An aqueous extract from the root bark of Pseudocedrela kotschyi and aerial parts of Adenia cissampeloides has been proven in previous research to elicit significant anticoagulant property in vitro. This, therefore, indicates the potential usefulness of this extract in managing thromboembolic disease, a major global health risk. The aim of the present work was to establish the antithrombotic effect of a product made from extracts of the root bark of P. kotschyi and the aerial parts of A. cissampeloides (PAE).

Experimental approach:
The effect of PAE at 500-2000 mg/kg in inhibiting tail infarction and inflammation, as well as its effect on the microthrombi count, hematological, and coagulation profiles in a carrageenan-induced thrombosis model in Sprague-Dawley rats, was studied.

Findings/Results:
PAE significantly (P ≤ 0.01-0.001) reduced length of tail infarction and inflammation (redness, swelling, pain, and temperature). Histopathological studies revealed a significant reduction (P ≤ 0.0001) in microthrombi count in the liver and the lungs with PAE treatment. PAE treatment caused a marginal (P ≤ 0.01) increase in prothrombin time but resulted in a significant (P ≤ 0.01-0.0001) dose-dependent increase in activated partial thromboplastin time, with the hematological profile being normal.

Conclusion and implications:
PAE showed anticoagulant and antithrombotic effects in vivo, indicative of its potential benefit as a natural product, and cost-effective therapeutic option, and hence could be helpful in thromboembolic therapies.
Cheiloscopy and dermatoglyphics in normal and obese individuals
Authors: Shivakumar Hosmath G , Nandini D B , Mohan Kumar K P , Selvamani M , Priya N K , Madhushankari G S 
Published: June 2021

Background:
The prevalence of obesity has been steadily increasing worldwide. Reliable and noninvasive tools that can be used to diagnose such conditions may help us in mass screening and prevention. Finger prints and lip prints have been used as the genetic markers in some diseases such as diabetes mellitus. Studies to correlate a possible association of such markers among obese individuals have not been reported in India to date. The present study was conducted to determine and compare the lip print and finger print patterns in normal and obese individuals and also to evaluate any possible correlation between the lip prints and finger prints in both the study groups.

Methodology:
Lip and finger print patterns of 100 obese and equal number of age- and sex-matched healthy individuals were analyzed. Right thumb, right index, left thumb and left index finger prints were evaluated. Gender-wise comparison was also made.

Results:
Lip prints revealed no significant difference between obese and nonobese individuals. Predominant Type I lip print was observed in both the study groups. Comparison of finger prints between obese and nonobese individuals revealed a highly significant results for all the fingers. Predominant finger print patterns in the right thumb, right index, left thumb and left index among obese individuals were whorl (51%), loop (83%), whorl (79%) and arch (74%), respectively. No correlation between the lip prints and finger prints was noted.

Conclusion:
Finger prints in the obese individuals showed significant differences when compared to the normal controls while lip prints failed to reveal any significant difference. Lip prints did not correlate with the finger prints. Right thumb revealed a significant gender difference among obese individuals.
Assessment of immunohistochemical expression of p16 in head and neck squamous cell carcinoma and their correlation with clinicopathological parameters
Authors: Pandey Pinki , Ralli Megha , Dixit Alok , Agarwal Savita , Chaturvedi Vineet , Sawhney Anshul , Agarwal Roopak 
Published: June 2021

Introduction:
Oral squamous cell carcinoma is a major cause of death throughout the developed world. It is associated with tobacco chewing, paan chewing and alcohol consumption. Human papillomavirus (HPV) type 16 has also been suggested to play a role in the etiology of head-and-neck squamous cell carcinoma (HNSCC). p16 expression is now being used as a surrogate marker of HPV infection in squamous cell carcinoma.

Materials and Methods:
In this cross-sectional observational study, a total of 100 cases of HNSCC were taken. p16 expression was determined by immunohistochemical (IHC) staining and correlated with clinicopathological parameters. The obtained results were analyzed and evaluated using Chi-square test, value of P < 0.05 was taken significant.

Results:
P16 was positive in 60% of cases. A statistically significant direct association was observed between p16 with age, site of the tumor, abnormal sexual habits and lymph node involvement.

Conclusion:
IHC expression of p16 can be used as a surrogate marker of HPV. Study of p16 expression may provide clinicians with more exact information in order to evaluate tumor aggressiveness, treatment modalities and can provide support for vaccination program in a high-risk group.
A comparative study to assess risk of oral candidiasis in pregnant and nonpregnant women
Authors: Shaimaa  , Zainab Heena , Hugar Deepa , Sultana Ameena 
Published: June 2021

Background:
The major hormonal changes observed in pregnant women lead to an imbalance in the oral environment. Hence, recent studies suggest that the placenta may harbor a unique microbiome that may have originated in the maternal oral microbiome.

Aim:
The present study aimed to assess the risk factor of oral candidiasis in pregnancy and to evaluate the prevalence of Candida species in the oral cavity of pregnant women in all three trimesters. The comparison was also done between pregnant and nonpregnant women to evaluate the cause of the prevalence of candidal species.

Materials and Methods:
Thirty pregnant and thirty nonpregnant women aged between 20 and 30 years were included in the study that were healthy and who did not have any obvious lesion in the oral cavity. The sterile swabs were used to collect samples from the oral cavity from both the groups by brushing the dorsum of the tongue and buccal mucosa. The pregnant women were followed throughout the pregnancy, i.e., in every trimester, for the sample collection. The samples were then cultured on Sabouraud Dextrose Agar media. The positive growth on culture plates was then inoculated on HiCrome agar differential agar media for speciation.

Results:
Statistical analysis was done by comparing the positive growth in pregnant and nonpregnant women using Fisher's exact test. The pregnant women were compared in three trimesters using the McNemar Chi-square test.

Conclusion:
The study concludes that there was no significant presence of Candidal species when compared between pregnant and nonpregnant groups. The prevalence of Candida species also remained the same.
Expression of stem cell marker cytokeratin 19 in reduced enamel epithelium, dentigerous cyst and unicystic ameloblastoma – A comparative analysis
Authors: Akhila C N V , Sreenath G , Prakash A Ravi , Rajini Kanth M , Reddy A Vikram Simha , Kumar S Naveen 
Published: June 2021

Background:
The process of odontogenesis is complex involving epithelial–mesenchymal interactions, along with the molecular signaling pathways triggering the initiating process. The triggering factors and cells precisely involved in the pathogenesis of odontogenic cysts and tumors are unknown. There is a vast array of biomarkers used to stain different sites, thereby helpful in diagnosing and evaluating the prognosis of these cysts and tumors. Cytokeratins are the intermediate filament proteins which maintain cell integrity and alter their properties in cysts and tumors. In the following study, cytokeratin 19 expression patterns are assessed quantitatively in reduced enamel epithelium, dentigerous cyst and unicystic ameloblastoma.

Aim:
The aim of present study is to assess expression of CK 19, a stem cell marker in reduced enamel epithelium, dentigerous cyst and unicystic ameloblastoma, quantitatively.

Materials and Methods:
The present study is carried out with 15 samples in each group. Reduced enamel epithelium is derived from the patients undergoing treatment for impacted teeth. Histopathologically diagnosed cases of dentigerous cyst and unicystic ameloblastoma were considered for the study. With the help of Olympus BX 43 microscope, with ProgRes microscope camera, the 45 slides obtained were examined. The region of interest was selected in each slide and number of cells positively stained was counted. Data were analyzed using SPSS software version 23. Descriptive for scale data, One way anova with post hoc Tukey's test for intergroup comparison.

Results:
The results showed significant P value <0.05. Expression of CK 19 was highest in reduced enamel epithelium, followed by dentigerous cyst and unicystic ameloblastoma.

Conclusion:
CK 19 can be used as diagnostic marker to differentiate between odontogenic cyst and tumor.
Correlation of lip print with blood group in forensic science
Authors: Kesarwani Pallavi , Choudhary Anand 
Published: June 2021

Background:
Cheiloscopy is the study of furrows and grooves present on the red part, or the vermilion border of the human lips. The type of groves is unique for an individual and can be used for person identification.

Aim:
The aim of this study is to ascertain whether the uniqueness of lip print (LP) can help in identifying a person. In addition to evaluate the comparison of LP types and blood groups was taken up to see if there is any correlation between the two.

Materials and Methods:
A cross-sectional study was conducted on 200 participants (77 males and 123 females), aged between 25 to 45 years, to determine any correlation between LP types and blood groups. These lip patterns were analyzed and interpreted using Tsuchihashi's classification and later associated blood group matching was performed to determine the predominant LP type with the ABO and Rh blood grouping system.

Results:
The present study showed a positive correlation between LP pattern and blood group among males and females. Thus, distribution of LP patterns, and ABO blood groups might help in the identification of an individual.

Conclusion:
Since LP and blood group are unique for a person. Hence, cheiloscopy along with blood group can play a vital role in person identification.
The perceived impact of webinars during the COVID.19 pandemic
Authors: Mishra Deepak , Nair Akshay Gopinathan , Verma Lalit , Grover Ashok Kumar , Mathur Satanshu , Srivastav Tanmay 
Published: June 2021

OBJECTIVE:
The objective of the study was to assess the perceived utility and the impact of web-based teaching programs being conducted following the COVID-19 pandemic.

METHODS:
An online survey was sent to trainee ophthalmologists across India through various social media platforms. The responses were tabulated and analyzed.

RESULTS:
A total of 768 valid responses were recorded. Majority of respondents (52.2%) felt that the ideal duration for webinars was 1 hour or less. Factors that helped trainees in choosing a webinar were the topic (95.1%), the timing (53.6%), and the speaker list (42.4%). Residents indicated a preference for webinars to attend aimed at postgraduate residency training, more specifically clinical problem-solving. Further questions were answered using a 1-10 Likert scale (1: least useful and 10: extremely useful). The median score when asked for overall usefulness of the webinars in general was 8 (interquartile range/IQR: 2). The median response when asked about utility of webinars in enhancing theoretical knowledge was 8 (IQR: 2) and the median for utility of webinar-based teaching programs in enhancing practical knowledge/surgical learning was also 8 (IQR: 2). The median score when asked about the utility of the webinar programs in acquiring skills for writing research papers/thesis was 7 (IQR: 3). Connectivity issues, audio/voice issues, and the long duration of webinars were some of the problems faced while attending webinars.

CONCLUSIONS:
Ophthalmology trainees in India found online teaching programs and webinars to be useful in enhancing their theoretical knowledge and practical skills/surgical learning. Administrators and educational institutes should tailor online teaching programs as per the needs and preferences of the residents.
Evaluation of Commercial Rapid Lateral Flow Tests, Alone or in Combination, for SARS-CoV-2 Antibody Testing
Authors: Fischer Peter U. , Fischer Kerstin , Curtis Kurt C. , Huang Yuefang , Fetcho Nicole , Goss Charles W. , Weil Gary J. 
Published: June 2021

ABSTRACT.
Antibody tests can be tools for detecting current or past severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 [coronavirus disease 2019 (COVID-19)]) infections. Independent test evaluations are needed to document the performance with different sample sets. We evaluated six lateral flow assays (LFAs) and two laboratory-based tests (EUROIMMUN-SARS-CoV-2 ELISA and Abbott-Architect-SARS-CoV-2-IgG). We tested 210 plasma samples from 89 patients diagnosed with acute COVID-19. These samples were collected at different time points after the onset of symptoms. In addition, 80 convalescent plasma samples, and 168 pre-pandemic samples collected from adults in the United States and in Africa were tested. LFA performance varied widely, and some tests with high sensitivity had low specificity. LFA sensitivities were low (18.8–40.6%) for samples collected 0 to 3 days after symptom onset, and were greater (80.3–96.4%) for samples collected > 14 days after symptom onset. These results are similar to those obtained by ELISA (15.6% and 89.1%) and chemiluminescent microparticle assay (21.4% and 93.1%). The range of test specificity was between 82.7% and 97%. The combined use of two LFAs can increase specificity to more than 99% without a major loss of sensitivity. Because of suboptimal sensitivity with early COVID-19 samples and background reactivity with some pre-pandemic samples, none of the evaluated tests alone is reliable enough for definitive diagnosis of COVID-19 infection. However, antibody testing may be useful for assessing the status of the epidemic or vaccination campaign. Some of the LFAs had sensitivities and specificities that were comparable to those of more expensive laboratory tests, and these may be useful for seroprevalence surveys in resource-limited settings.
Planned Obsolescence, Total Quality, Zero Defects and Global Competition
Authors: Brondoni Silvio 
Published: June 2021

A global firm's success is conditioned by its ability to manage the system of intangible corporate assets (corporate culture, corporate identity, and information system) and intangible product assets (product design, brand equity and pre/after-sales services). Corporate imitation and innovation processes are a primary condition to compete in global markets and entail identifying and proposing design management products with 'new' features that change over time and space. Product design defines the functions that qualify a product or service to identify and organise the distinctive specifications of the firm’s offer, and develop goods and services based on the analysis of competition and demand needs (customer satisfaction). Competitive design management can be oriented towards different forms of flexible production (The Fourth Industrial Revolution), specifically related to products based on planned obsolescence, total quality, or a rigid competitive philosophy of zero defects.
Modelo psicoterapéutico EMDR aplicado a neurociencias
Authors: Pérez Pernillo Eslia Yesenia , Godínez Coz Carla Suyana 
Published: June 2021

Las neurociencias han jugado un papel muy importante desde finales del siglo XX y los inicios del siglo XXI, en el estudio del comportamiento humano y el trauma psicológico, actualmente se cuenta con herramientas muy poderosas como las neuroimágenes para observar la actividad cerebral en tiempo real, estas permiten observar la actividad eléctrica y/o química de las áreas cerebrales que propician o no la regulación de la emocionalidad y el comportamiento. Se realizó una revisión y recolección de información de los últimos estudios realizados basándonos en fuentes confiables de consulta. La terapia EMDR es un modelo psicoterapéutico, fue descubierto y desarrollado por la doctora Francine Shapiro, en 1987. Consta de 8 fases: 1. Historia 2. Preparación 3. Evaluación 4. Desensibilización 5. Instalación 6. Chequeo corporal 7. Cierre y 8. Reevaluación (Shapiro, 2017). Incluye un protocolo de las tres vertientes: Pasado – Presente - Futuro. Recientemente se han publicado datos importantes de resultados de investigaciones en las que se evidencia el cambio en la activación de las áreas cerebrales antes, durante y después de la terapia EMDR. Propiciando el alivio del sufrimiento humano generado por trauma psicológico.
TRANSESOPHAGEAL ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT ATRIAL THROMBUS IN PATIENTS OF RHEUMATIC SEVERE MITRAL STENOSIS WITH NEGATIVE RESULT ON TRANSTHORACIC ECHOCARDIOGRAPHY
Authors: Khan Tariq Mehmood , Akhtar Ammar , Farid Muhammad Ikram , Hashmi Kashif Ali , Bhutta Muhammad Masud Iqbal 
Published: June 2021

Objective: The objective of the study was to assess the frequency of clot in left atrium by transesophageal echocardiographic diagnostic procedure (TEE) in patients with rheumatic severe mitral stenosis (MS) in those patients in whom transthoracic echocardiographic diagnostic procedure (TTE) did not observe any clot in left thrombus.
Methodology: The descriptive cross-sectional study was carried out on 369 patients with rheumatic severe MS. Patients having mitral valve are of 1.5 cm2 or less planned for PMV were included in study. Non-cooperative patients were excluded. It was decided to do TEE on a similar day before the intervention to assess LA thrombus.
Results: The mean age of the included patients was 45.65 ±11.54 years. There were 122 (33.1%) male patients and 247 (66.9%) female patients. In this study, clot in LA was diagnosed in 29.5% patients having negative TTE. LA clot was found in 33 male patients (30.3%) and 76 female patients (69.7%).
Conclusion: There is a high risk of missing LA thrombus on transthoracic echocardiography, therefore we recommend performing TEE in patients with normal TTE study before the procedure.
CORONARY ARTERY DISEASE ON CT-CORONARY ANGIOGRAM – COMPARISON BETWEEN DIABETIC AND NON-DIABETIC POPULATION
Authors: Zaffar Muhammad Zubair , Akhtar Ammar , Bukhari Syed Naseem Iqbal , Minhas Rashid 
Published: June 2021

Objective: To evaluate the CT coronary angiograms of patients presenting with symptoms of coronary artery disease (CAD) as well as to compare the results between the diabetics and non-diabetics.
Methodology: This descriptive cross-sectional study was carried out in Cardiology department of Chaudhary Pervaiz Elahi Institute of Cardiology, Multan. One hundred and fifty nine patients with history of symptoms of CAD and no previous history of myocardial infarction or revascularization were included in study. The conventional risk factors were noted and 64 slice multi detector CT coronary angiogram was done on all patients. Total calcium score and number of segments with disease, obstructive disease and non-obstructive disease were noted. Results were compared among diabetic and non-diabetic patients.
Results: Mean age of the patients was 50.54±7.90 years. Out of 159 patients 118(74.2%) were males and 41 (25.8%) were females. Diabetic patients were 101(63.5%), 64 (40.3%) were hypertensive, 39(24.5%) were smokers, 24.5% (n=39) had positive family history, 18.2% (n=29) were obese and 13.8% (n=22) had dyslipidemia. There was no coronary artery disease in 40 (25.2%) patients while 91 (57.2%) patients had obstructive and 28 (17.6%) patients had non-obstructive disease. 83. 1% diabetics had obstructive CAD and 12.0% of non diabetic patients had obstructive CAD. Mean number of obstructive segments in diabetic patients are 2.36±1.23.
Conclusion: CAD was more prevalent in diabetic patients and CAD is easily predicted by non-invasive technique of CT coronary angiography.