bluuebunny/crossref_metadata_2025_split huggingface dataset:
TFF3 mediates the NF‐κB/COX2 pathway to regulate PMN‐MDSCs activation and protect against necrotizing enterocolitis
Authors: Liu Jingping , Yang Qiong , Chen Ziyang , Lv Shuaijun , Tang Jian , Xing Zhe , Shi Mengyu , Lei Aihua , Xiao Gang , He Yumei 
Published: February 2021

AbstractIntestinal trefoil factor 3 (TFF3) plays an important role in repairing the intestinal mucosa. However, the detailed mechanism regarding immune regulation by TFF3 is not well defined. Here, we reported that treatment of mouse BM cells and human peripheral blood mononuclear cells from healthy volunteers with TFF3 activated polymorphnuclear myeloid‐derived suppressor cells (PMN‐MDSCs) in vitro. We also found that prostaglandin E2 is a major TFF3‐mediated MDSC target, and that NF‐κB/COX2 signaling was involved in this process. Moreover, TFF3 treatment or transfer of TFF3‐derived PMN‐MDSCs (TFF3‐MDSCs) to experimental necrotizing enterocolitis (NEC) mice caused PMN‐MDSC accumulation in the lamina propria (LP), which was associated with decreased intestinal inflammation, permeability, bacterial loading, and prolonged survival. Interestingly, no NEC severity remission was observed in Rag1 KO mice that were given TFF3‐MDSCs, but coinjection with CD4+ T cells significantly relieved NEC inflammation. Overall, TFF3 mediates the NF‐κB/COX2 pathway to regulate PMN‐MDSC activation and attenuates NEC in a T‐cell‐dependent manner, which suggests a novel mechanism in preventing NEC occurrence.
Phosphorescent Cyclometalated Platinum(II) Imidazolinylidene Complexes
Authors: Stipurin Sergej , Strassner Thomas 
Published: February 2021

AbstractWe present the synthesis and characterization of six novel bidentate
cyclometalated platinum(ii) complexes derived from saturated N‐heterocyclic carbene precursors, namely 1‐aryl‐3‐methyl‐1H‐4,5‐dihydroimidazolium salts. The title compounds were then synthesized by a multi‐step reaction, which includes an in situ generation of the silver carbene complex, followed by transmetalation to platinum and subsequent introduction of the β‐diketonate ligand. Structural characterization by NMR experiments and solid‐state structures prove the cyclometalation and the saturated backbone of the NHC motif. Photophysical and electrochemical properties of the platinum(ii) complexes were examined and studied in detail by DFT calculations. The title compounds are strongly emissive at room temperature in the sky‐blue region of the visible spectrum and show quantum yields of up to 71 % in a PMMA matrix.
Mn–Doped Hollow Na3V2O2(PO4)2F as a High Performance Cathode Material for Sodium Ion Batteries
Authors: Du Peng , Mi Kan , Hu Fangdong , Jiang Xiaolei , Zheng Xiuwen 
Published: February 2021

AbstractNa3V2O2(PO4)2F (marked as NVOPF) is a promising cathode material for sodium‐ion batteries owing to its high voltage and theoretical energy density, while the low electrical conductivity hinders its practical applications. Ion‐doping could effectively improve electronic conductivity and structural stability of these materials. In this study, Mn‐doping Na3V2−xMnxO2(PO4)2F (0≤x≤0.15) hollow microspheres were successfully synthesized by hydrothermal method in the presence of H2O2. Among these obtained materials, NVMOPF‐0.050 exhibits the best electrochemical performance with initial discharge capacity of 118 mAh g−1 and 61 mAh g−1 at 0.1 C and 2 C as cathode material for sodium ion batteries. Excellent performance can be attributed to the hollow spherical architecture, and good structural stability.
One foot out the door: Stay/leave ambivalence predicts day‐to‐day fluctuations in commitment and intentions to end the relationship
Authors: Joel Samantha , Stanton Sarah C. E. , Page‐Gould Elizabeth , MacDonald Geoff 
Published: February 2021

AbstractWhy do some people maintain stable feelings of commitment toward their partners, whereas others’ feelings wax and wane from day to day? The current article draws insight from decision conflict research suggesting that individuals torn between decision options are particularly susceptible to attitude change. In three samples, we validated a stay/leave ambivalence scale to capture internal conflict about whether to remain in versus exit a relationship. In two dyadic daily experience studies, individuals who felt more ambivalent about their relationships experienced greater daily fluctuation in commitment and breakup contemplation compared to less ambivalent individuals. Ambivalent individuals’ relationship intentions were also more strongly tied to their daily experiences, such that they felt more motivated to stay on days with greater relationship positivity, and more motivated to leave on days with greater relationship negativity. We discuss implications of these results for ambivalent individuals, their partners, and our understanding of stay/leave decision processes.
Tethered humanity: Humanizing self and others in response to interpersonal harm
Authors: Vaes Jeroen , Bastian Brock 
Published: February 2021

AbstractWe propose an integrative framework in which the self‐image of perpetrators and victims in interpersonal conflictual relationships becomes tethered to each other. To the extent that both parties stop seeing themselves as fully human when interpersonal harm is inflicted, we theorize that this state motivates attempts at restoration. Specifically, we propose the tethered humanity hypothesis which ascertains that perpetrators or victims can reclaim their full human status by re‐establishing the humanness of the opposing party. This hypothesis was analyzed from both the perspective of the perpetrator (Studies 1–3) and the victim (Study 4). In all studies, results indicated that perpetrators or victims self‐dehumanize in response to interpersonal harm and managed to regain a full human status when re‐humanizing the opposing party. Interestingly, this process was interrupted when the opposing party did not accept attempts at reconciliation. Our findings offer a new interpersonal perspective on the implications of immoral behavior.
Partner support and goal outcomes during COVID‐19: A mixed methods study
Authors: Vowels Laura M. , Carnelley Katherine B. , Francois‐Walcott Rachel R. R. 
Published: February 2021

AbstractDuring the COVID‐19 pandemic, people have been stuck indoors with their partners for months. Having a supportive partner is likely to be especially important during this time when access to outside sources of support is limited. The present mixed‐methods study aimed to investigate how partner support is associated with goal outcomes during COVID‐19. The survey participants (n = 200) completed a daily diary for a week and five weekly longitudinal reports, and 48 participants attended a semi‐structured interview. The quantitative results showed that higher relational catalyst support (i.e., support for growth opportunities) predicted better goal outcomes; qualitative analyses revealed partners use direct and indirect forms of emotional and instrumental support toward goal pursuit. This is important because most studies to date have not differentiated between direct and indirect forms of support. Overall, the findings suggest that having a supportive partner is important for not only surviving, but also thriving through the pandemic.
Confrontation as an interpersonal response to ostracism
Authors: Zimmerman Carla A. , Carter‐Sowell Adrienne R. , Ganesan Asha 
Published: February 2021

AbstractOstracism—being ignored and excluded by others—has detrimental effects on targets. Confrontation allows targets to express displeasure with mistreatment. Three studies examined confrontation in response to ostracism. In Study 1, participants completed an ostracism manipulation, Cyberball, and were given the opportunity to message their ostracizers. Message coding indicated that one‐third of targets wrote messages expressing unhappiness with how they were treated, significantly more than included participants. In Studies 2 and 3, participants completed Cyberball before random assignment to a distraction, writing, or confrontation task. Analysis of need‐recovery indicated that the distraction consistently improved need‐satisfaction and affective recovery between the immediate and delayed measurements. Results provided mixed support regarding the effectiveness of confrontation in coping with ostracism; however, no significant changes in need satisfaction were seen for those in the writing condition. In sum, distraction is a response to ostracism that may improve the recovery of depleted need‐satisfaction following ostracism better than confrontation.
‘Enemy of the people’: Family identity as social cure and curse dynamics in contexts of human rights violations
Authors: Kellezi Blerina , Guxholli Aurora , Stevenson Clifford , Ruth Helen Wakefield Juliet , Bowe Mhairi , Bridger Kay 
Published: February 2021

AbstractAlthough Social Cure research shows the importance of family identification in one's ability to cope with stress, there remains little understanding of family responses to human rights violations. This is the first study to explore the role of family identity in the collective experience of such violations: meanings ascribed to suffering, family coping strategies, and family‐based understandings of justice. Semi‐structured interviews (N = 27) with Albanian dictatorship survivors were analysed using Social Identity Theory informed thematic analysis. The accounts reveal Social Cure processes at work, whereby family groups facilitated shared meaning‐making, uncertainty reduction, continuity, resilience‐building, collective self‐esteem, and support, enhanced through common fate experiences. As well as being curative, families were contexts for Social Curse processes, as relatives shared suffering and consequences collectively, while also experiencing intergenerational injustice and trauma. Although seeking and achieving justice remain important, the preservation of family identity is one of the triumphs in these stories of suffering.
Optimization of the Design and Operating Conditions of an Amperometric Biosensor for Glutamate Concentration Measurements in the Blood Plasma
Authors: Mruga D. , Soldatkin O. , Paliienko K. , Topcheva A. , Krisanova N. , Kucherenko D. , Borisova T. , Dzyadevych S. , Soldatkin A. 
Published: February 2021

AbstractToday, the concentration of glutamate in the patient′s blood is an important indicator in medical diagnostics; therefore, it is necessary to have a simple, accurate, and fast tool to obtain the data. Here, a recently developed amperometric glutamate‐sensitive biosensor was optimized to improve its characteristics. The platinum disk electrode was used as a transducer. As a bioselective element we used the enzyme glutamate oxidase, covalently crosslinked with bovine serum albumin by glutaraldehyde. Circumstances of enzyme immobilization on the transducer‘s surface were optimized (enzyme and glutaraldehyde concentrations and immobilization duration). To test the ability of this biosensor to work in biological environments containing complex biological substances, the influence of the working solution was investigated (concentration of the working buffer, its temperature, presence of the protein in the analyzed sample). The linear range of biosensor was from 5 to 600 μM of glutamate and the sensitivity was 150–200 nA/mM. Measurements of glutamate concentrations in the blood plasma were performed by biosensor and glutamate dehydrogenase assay. The linear correlation between the methods was found in a range of 50.4–182.5 μM (R2=0.99). Thus, it has been shown that the developed biosensor makes it possible to measure the concentration of glutamate in blood plasma.
A Novel Sensor Based on Carbon Paste Electrode Modified with Polypyrrole/Multi‐walled Carbon Nanotubes for the Electrochemical Detection of Cytostatic Drug Rapamycin
Authors: Zrinski Ivana , Martinez Sanja , Ortner Astrid , Samphao Anchalee , Zavašnik Janez , Kalcher Kurt , Mehmeti Eda 
Published: February 2021

AbstractThe electrocatalytic oxidation of rapamycin, one of the most studied immunosuppressant, cancer‐preventing drug, is investigated for the first time on the surface of the modified carbon paste electrode prepared by incorporating multi‐walled carbon nanotubes (MWCNTs) and conductive polymer pyrrole using differential pulse voltammetry (DPV). Rapamycin exhibited a well‐defined oxidation peak at +1.1 V (versus Ag/AgCl) in Briton Robinson buffer solution with a pH 4.0. Effect of the most important experimental parameters was optimized and obtained signals are linear to the concentration of rapamycin in the range from 0.1 to 20 μM with 0.06 μM limit of detection. The repeatability is calculated as ±2 % and the reproducibility as ±5 %. The possible interfering compounds were tested showing negligible effect and the sensor was successfully applied for the determination of rapamycin in commercial pharmaceutical formulations with obtained recoveries in the range from 98 % to 102 %.
Simple carbazole derivatives with mono/dimethoxyphenylacrylonitrile substituents as hole‐transporting materials: Performance studies in hybrid perovskite solar cells
Authors: Keremane Kavya S. , Adhikari Airody Vasudeva 
Published: February 2021

AbstractHerein, we report the development of two new low‐cost 9‐(2‐ethylhexyl)‐9H‐carbazoles carrying the mono/dimethoxyphenyl substituted cyanovinylene units symmetrically at 3‐ and 6‐positions of the carbazole core (CZ1‐2), as potential hole‐transporting materials (HTMs) for perovskite solar cell (PSC) application. The current work highlights their structural, photophysical, electrochemical, theoretical, and photoelectrochemical studies, including evaluation of their structure‐property relationships. Evidently, the optical studies showcased their excellent fluorescence ability due to their push‐pull natured structure; their λabs and λemi values were found to be in the order of 410–430 nm and 530–560 nm, respectively, with a bandgap in the range of 2.5–2.6 eV. Further, their theoretical studies, performed by using the DFT simulations clearly revealed in‐depth information on their molecular geometries, FMO, and electronic properties. Finally, new PSCs were fabricated successfully by employing CZ1‐2 as HTMs to evaluate their photovoltaic performances. Their results indicated that the device with CZ1 displayed enhanced PCE of 2.55% (JSC = 7.85 mA/cm2, VOC = 0.79 V and FF = 40%) than the cell with CZ2 (PCE = 1.71%, JSC = 8.15 mA/cm2, VOC = 0.4 V, FF = 49%) and the obtained data are well comparable with reference, Sipro‐OMeTAD (PCE = 4.76%, JSC = 12.27 mA/cm2, VOC = 0.84 V, FF = 45%). Conclusively, the study furnishes a deeper understanding of the intricacies involved in the structural modification of in low‐cost HTM in achieving an enhanced performance of the devices.
Fresh insights into detonation nanodiamond aggregation: An X‐ray photoelectron spectroscopy, thermogravimetric analysis, and nuclear magnetic resonance study
Authors: Katsiev Khabiboulakh , Solovyeva Vera , Mahfouz Remi , Abou‐Hamad Edy , Peng Wei , Idriss Hicham , Kirmani Ahmad R. 
Published: February 2021

AbstractDetonation nanodiamonds (DNDs) are known to be produced in aggregated clusters of a few nanometer‐sized primary crystalline particles embedded in an amorphous carbon matrix exhibiting high degree of polydispersity. A commonly accepted mechanism behind DND aggregation is the bridging of primary particles via oxygen containing functionalities. Here, we provide definitive spectroscopic evidence in favor of this working mechanism by carrying out systematic chemical compositional analysis on monodispersed DND aggregates of various sizes. Oxygen content is found to increase proportionally with the aggregate size confirming the role of oxygen containing functionalities as a cross‐linker. Solid‐state nuclear magnetic resonance data confirms these linkers to be of ether (COC) nature. Our results imply that oxygen content in DNDs can be independently tuned by varying the aggregate size, a knowledge which might benefit other applications, in addition. Next, we use this understanding to engineer the DND surfaces via an acid hydrolysis step to strip off these oxygen functionalities leading to size reduction of ca. 150 nm as‐received DND aggregates to ca. 40 nm with >90% yields, without resorting to any other pre‐ or post‐hydrolysis treatment such as surface functionalization or milling.
Potential impact of global warming on wind power production in Central Asia
Authors: Turgali Dana , Kopeyeva Assel , Dikhanbayeva Dinara , Rojas‐Solórzano Luis 
Published: February 2021

AbstractGlobal warming is affecting the Earth's surface temperature and consequently the intensity of near‐surface airstreams and wind power potential in many regions. Conversely, global wind power installed capacity is continuously growing during the last years. The economic viability and sustainability of centralized wind projects relies heavily on wind resources, efficient technologies, and an attractive and dynamic Feed‐in‐Tariff (FIT). Therefore, this study assesses the potential effect of global warming on the life‐cycle techno‐economic viability of future wind power projects in Central Asia, specifically in Kazakhstan. Hence, the Ereymentau Wind Power Plant (WPP) in the Northern region of Kazakhstan was selected as case study. Historic data showed that monthly averaged wind speed and ambient pressure can be treated as statistically stationary, and only the air density drop due to temperature increase of 0.2°C per decade is assumed in the present study. Our results predict a reduction in Net Present Value, Benefit–Cost Ratio, and Internal Rate of Return of 29 million KZT, of 0.0015, and 0.03%, respectively, in the lifetime of Ereymentau WPP. Moreover, an Equity payback increase of 0.4 years and a drop of 987 tCO2e in GHG emission reductions are projected. Consequently, our results indicate that global warming, despite of being a global problem of significance, would have a negligible impact in ongoing plans to develop the wind potential in Northern regions of Eurasian countries sharing similar conditions to those present in Ereymentau‐Kazakhstan.
Optimization of microalgal biomass and lipid productivities for bioenergy production using central composite design with desirability function
Authors: Zakir Hossain S. M. , Sultana N. , Hossain M. M. , Razzak S. A. 
Published: February 2021

SummaryThis study investigates the influences of light‐dark cycles and NaNO3 dose on Chlorella kessleri microalgal‐specific growth rate (SGR), biomass productivity (P), and intracellular lipid productivity (LP) by using central composite design with desirability function. A single‐objective optimization showed that the maximum SGR, P, and LP can be achieved as 0.487 day−1, 58.718 g/L day−1, and 14.252 mg/L day−1, respectively. The corresponding optimized light‐dark cycle and NaNO3 loading were determined as 11.6/8.4 (h/h) and 15.54 g/L, 12/12 (h/h) and 16.23 g/L, and 12/12 (h/h) and 6.63 g/L, respectively. The multi‐response optimization showed that the highest SGR of 0.359 day−1, biomass productivity of 50.663 g/L day−1 and LP of 14.114 mg/L day−1 can be accomplished at culture environments of 12/12 (h/h) light‐dark cycles and 10.38 g/L NaNO3. These results suggest that the central composite design with desirability function‐based technique is useful for design and operation of photobioreactors to produce lipid from microalgae. Analysis of variance was employed to explore the significance of the factors affecting microalgal growth as well as biomass and lipid productivities. The predicted optimized culture conditions were experimentally confirmed (error < 6%) indicating the process is robust and reliable.
Special issue: Marine and river bedforms dynamics, MARID VI
Authors: Lefebvre Alice , Winter Christian 
Published: February 2021

AbstractMarine and river bedforms are rhythmic features driven by unidirectional or reversing currents and waves. They are ubiquitous on the floors of rivers, estuaries, coastal and marine settings. Despite a considerable history of dedicated studies, many aspects of their origin, development and dynamics are still the subject of scientific debate in various disciplines. The MARID conferences series hosts experts from geosciences, physics, engineering and other disciplines to provide a platform for the interdisciplinary exchange of fundamental and applied knowledge of marine and river dune dynamics. MARID VI took place in April 2019 in Bremen, Germany. Related scientific contributions are presented in this special issue of Earth Surface Processes and Landforms. An overview of the conference series and the specifics of MARID VI, as well as considerations in the context of equity, diversity and inclusion, are given. This introduction highlights the progress made with the papers published in the special issue.
6G: A comprehensive survey on technologies, applications, challenges, and research problems
Authors: Mahmoud Haitham Hassan H. , Amer Amira A. , Ismail Tawfik 
Published: February 2021

AbstractThe inherent limitations of the network keep on going to be revealed with the continuous deployment of cellular networks. The next generation 6G is motivated by these drawbacks to properly integrate important rate‐hungry applications such as extended reality, wireless brain‐computer interactions, autonomous vehicles, and so on. Also, to support significant applications, 6G will handle large amounts of data transmission in smart cities with much lower latency. It combines many state‐of‐the‐art trends and technology to provide higher data rates for ultra‐reliable and low latency communications. By outlining the system requirements, potential trends, technologies, services, applications, and research progress, this article comprehensively conceptualized the 6G cellular system. Open research issues and current research groups in their field of research are summarized to provide readers with the technology road‐map and the potential challenges to consider in their 6G research.
Using niche construction theory to generate testable foraging hypotheses at Liang Bua
Authors: Veatch Elizabeth G. , Ringen Erik J. , Kilgore Megan B. , Jatmiko  
Published: February 2021

AbstractNiche construction theory (NCT) has emerged as a promising theoretical tool for interpreting zooarchaeological material. However, its juxtaposition against more established frameworks like optimal foraging theory (OFT) has raised important criticism around the testability of NCT for interpreting hominin foraging behavior. Here, we present an optimization foraging model with NCT features designed to consider the destructive realities of the archaeological record after providing a brief review of OFT and NCT. Our model was designed to consider a foragers decision to exploit an environment given predation risk, mortality, and payoff ratios between different ecologies, like more‐open or more‐forested environments. We then discuss how the model can be used with zooarchaeological data for inferring environmental exploitation by a primitive hominin, Homo floresiensis, from the island of Flores in Southeast Asia. Our example demonstrates that NCT can be used in combination with OFT principles to generate testable foraging hypotheses suitable for zooarchaeological research.