bluuebunny/crossref_metadata_2025_split huggingface dataset:
HClO‐Activated Near‐Infrared Chemiluminescent Probes with a Malononitrile Group for In‐Vivo Imaging
Authors: Cao Yalei , Gu Juqing , Chen Zhijian , Gao Jucai , Yang Jie , Wu Wenbo , Fang Manman , Li Qianqian , Liu Bin , Li Zhen 
Published: December 2024

AbstractChemiluminescence (CL) imaging has emerged as a powerful approach to molecular imaging that allows exceptional sensitivity with virtually no background interference because of its unique capacity to emit photons without an external excitation source. Despite its high potential, the application of this nascent technique faces challenges because the current chemiluminescent agents have limited reactive sites, require complex synthesis, are insufficiently bright, and lack near‐infrared emission. Herein, a series of HClO‐activated chemiluminescent probes that exhibit robust near‐infrared emission are studied. Specifically engineered to respond to HClO, a known biomarker of acute inflammation, these probes achieve high‐contrast in vivo imaging by eliminating the need for constant external excitation. Comprehensive experimental and theoretical investigations demonstrate that the CL of the probes depends on the reactivity of the vinylene bonds, following a concerted decomposition of the oxidized chemiluminescent molecule. The application of these chemiluminescent nanoparticles in vivo facilitates high‐contrast imaging of acute inflammation, providing real‐time, high‐contrast visualization of inflammatory conditions. This advancement signifies a leap forward for chemiluminescent nanoplatforms in biomedical imaging and expands the available methodologies in this field.
Tough Polyurethane Hydrogels with a Multiple Hydrogen‐Bond Interlocked Bicontinuous Phase Structure Prepared by In Situ Water‐Induced Microphase Separation
Authors: Wang Ruyue , Xu Ting , Yang Yuxuan , Zhang Mengyuan , Xie Ruilin , Cheng Yilong , Zhang Yanfeng 
Published: December 2024

AbstractHydrogels with mechanical performances similar to load‐bearing tissues are in demand for in vivo applications. In this work, inspired by the self‐assembly behavior of amphiphilic polymers, polyurethane‐based tough hydrogels with a multiple hydrogen‐bond interlocked bicontinuous phase structure through in situ water‐induced microphase separation strategy are developed, in which poly(ethylene glycol)‐based polyurethane (PEG‐PU, hydrophilic) and poly(ε‐caprolactone)‐based polyurethane (PCL‐PU, hydrophobic) are blended to form dry films followed by water swelling. A multiple hydrogen bonding factor, imidazolidinyl urea, is introduced into the synthesis of the two polyurethanes, and the formation of multiple hydrogen bonds between PEG‐PU and PCL‐PU can promote homogeneous microphase separation for the construction of bicontinuous phase structures in the hydrogel network, by which the hydrogel features break strength of 12.9 MPa, fracture energy of 2435 J m−2, and toughness of 48.2 MJ m−3. As a biomedical patch, the outstanding mechanical performances can withstand abdominal pressure to prevent hernia formation in the abdominal wall defect model. Compared to the commercial PP mesh, hydrogel can prevent tissue/organ adhesion to reduce inflammatory responses and promote angiogenesis, thereby accelerating the repair of abdominal wall defects. This work may provide useful inspiration for researchers to design different gel materials through solvent‐induced microphase separation.
Popularizing Holistic High‐Index Crystal Plane via Nonepitaxial Electrodeposition Toward Hydrogen‐Embrittlement‐Relieved Zn Anode
Authors: Zou Yuhan , Mu Yongbiao , Xu Liang , Qiao Changpeng , Chen Ziang , Guo Wenyi , Gu Jiaxi , Su Yiwen , Zeng Lin , Cheng Tao , Sun Jingyu 
Published: December 2024

AbstractElectrodeposition is promising to fabricate Zn electrodes affording nonepitaxial single‐crystal textures. Previous research endeavors focus on achieving Zn(002) faceted deposition, nevertheless, the popularization of a high‐index Zn plane with favorable electrochemical activity remains poorly explored. There also exists a deficiency in the assessment of the electrodeposited quality of Zn. Here, a straightforward strategy to address such concerns by cultivating predominant Zn(112) texture via a potentiostatic electrodeposition mode is reported. By precisely identifying the “limiting” conditions for electrodeposition, a striking balance between improved deposition quality, tailored deposition kinetics, and suppressed hydrogen evolution is found. (002) Faceted Zn electrode is shown that be indeed produced, yet the rampant hydrodynamic convection and hydrogen embrittlement issue under such “over‐limiting” preparation conditions pose challenges in the electrode lifespan. In contrast, an optimized deposition minimizes hydrodynamic disturbances and mitigates the hydrogen embrittlement effect, where the thus‐generated high‐index (112)‐textured Zn electrode manifests impressive deposition quality and demonstrates holistic cycling stability. The pouch cell by pairing a ZnxV2O5 (ZnVO) cathode manages a reversible capacity of ≈130 mAh and a capacity retention of 98.42%. This study offers guidance for the development of dendrite‐free and hydrogen‐embrittlement‐relieved Zn anodes, unleashing the potential of high‐index plane textures for advanced Zn batteries.
Creating Single‐Crystalline β‐CaSiO3 for High‐Performance Electronic Packaging Substrate
Authors: Jia Qingchao , Wang Wenzhi , Zhang Hujun , Chen Chunyu , Li Ao , Chen Chen , Yu Hang , Zhang Liangzhu , Tao Haizheng , Zeng Huidan , Luo Xiongke , Yue Yuanzheng 
Published: December 2024

Abstractβ‐CaSiO3 based glass‐ceramics are among the most reliable materials for electronic packaging. However, developing a CaSiO3 glass‐ceramic substrate with both high strength (>230 MPa) and low dielectric constant (<5) remains challenging due to its polycrystalline nature. The present work has succeeded in synthesizing single‐crystalline β‐CaSiO3 for a high‐performance glass‐ceramic substrate. This is accomplished by introducing Al3+ into the CaO‐B2O3‐SiO2 glass system, and by optimizing the sintering condition. Al3+ doping facilitates a heterogeneous network structure that energetically favors the precipitation of polycrystalline particles, including nanosized β‐CaSiO3 crystals and sub‐nanosized α‐CaSiO3 crystals. As the sintering temperature increases, the nano α‐CaSiO3 crystals (2–10 nm) are gradually absorbed by the β‐CaSiO3 crystals. Through atomic rearrangement, α‐CaSiO3 crystals transform into micrometer‐sized single crystal β‐CaSiO3 (1–2 µm) with layered structure. The low temperature co‐fired β‐CaSiO3 glass‐ceramics exhibit exceptional properties, including a low dielectric constant of 4.04, a low dielectric loss of 3.15 × 10−3 at 15 GHz, and a high flexural strength of 256 MPa. This work provides a new strategy for fabricating high‐performance single‐crystalline glass‐ceramics for electronic packaging and other applications.
Matching P‐ and N‐type Organic Electrochemical Transistor Performance Enables a Record High‐gain Complementary Inverter
Authors: Kuang Yazhuo , Yao Tangqing , Deng Sihui , Dong Jingjin , Ye Gang , Zhang Linlong , Shao Shuyan , Zhu Zhongjie , Liu Jun , Liu Jian 
Published: December 2024

AbstractThe charge transport of channel materials in n‐type organic electrochemical transistors (OECTs) is greatly limited by the adverse effects of electrochemical doping, posing a long‐standing puzzle for the community. Herein, an n‐type conjugated polymer with glycolated side chains (n‐PT3) is introduced. This polymer can adapt to electrochemical doping and create more organized nanostructures, mitigating the adverse effects of electrochemical doping. This unique characteristic gives n‐PT3 excellent charge transport in the doped state and reversible ion storage, making it highly suitable as an n‐type organic mixed ionic‐electronic conducting (OMIEC) material. n‐PT3 exhibits a high electron mobility of µ ≈ 1.0 cm2 V−1 s−1 and a figure of merit value of µC* ≈ 100 F cm−1 V−1 s−1, representing one of the best results for n‐type OMIEC materials. A new p‐type OMIEC polymer has been synthesized as the channel material for constructing a complementary inverter to match the n‐type OECT channel layer based on n‐PT3. As a result, a voltage gain value of up to 307 VV−1 has been achieved, which is a record value for sub−1 V complementary inverters based on OECTs. This work offers valuable insights into designing electrochemical doping adaptive n‐type OMIEC materials and fabricating high‐gain organic complementary inverters.
Manipulation Study of Bubble‐Propelled Hydrogel Microbots
Authors: Li Mingliang , Wang Ping , Zhang Hui , Liu Ping , Liu Guangli , Sui Cong , Yang Runhuai , Luo Tingting 
Published: December 2024

AbstractMicrobots have shown considerable potential in the biomedical field. Their capability to target specific areas for diagnosis, treatment, and other applications with minimal invasiveness is particularly advantageous. However, complex application environments and harsh driving conditions greatly limit the locomotion behaviors of microbots, and therefore the locomotion mode of microbots deserves more exploration and research. This study focuses on a near‐infrared light‐driven bubble‐propelled microbot. The photothermally responsive materials used in the design are modified to enhance bubble generation properties. Additionally, the controlled 3D printing preparation process can indirectly influence the bubble aggregation pathway by altering the microbot's micro‐nanostructured porous structure. Ultimately, by adjusting the laser parameters, the microbot can be controlled to achieve a variety of locomotion modes. Furthermore, the experimental observations and theoretical analysis of the microbot's locomotion modes are summarized. A preliminary digital description is provided, which verifies the feasibility of controlling these locomotion modes. This lays the foundation for the precise control of microbots in future applications.
Copper‐Catalyzed Reductive Coupling of Nitroalkanes with Aliphatic Grignard/Cerium and Organozinc Reagents for Synthesis of Functionalized Nitrones
Authors: Hata Takeshi , Nishi Koki , Yamaguchi Koki , Tatsumi Yuta , Tanaka Naomi , Shigeta Masayuki , Urabe Hirokazu 
Published: December 2024

AbstractThis study aims to develop a more efficient, functional‐group‐tolerant approach using stable nitroalkanes and reductive coupling reactions with aliphatic Grignard/cerium and organozinc reagents. The treatment of nitroalkanes with aliphatic Grignard reagents in the presence of a catalytic amount of CuF2 and stoichiometric amount of CeCl3 affords various nitrones in good yields as single isomers. The reaction of tertiary nitroalkanes with organozinc reagents affords various functionalized nitrones without CuF2 or CeCl3. These reductive coupling reactions proceed without the loss of functional groups such as alkene, alkyne, benzyl ether, chlorine, ester, and nitrile moieties. Nitrones can also be used as precursors for [3+2] cyclizations with electron‐withdrawing alkenes and alkynes.
Copper and DMAP Relay‐Catalyzed Three‐Component coupling of Terminal Alkynes, Anthranils and Alcohols for the Modular Synthesis of 2‐alkoxy Quinolines
Authors: Li Haixia , Gao Yang , Zhong Xiongwei , Huo Yanping , Li Xianwei , Chen Qian 
Published: December 2024

AbstractA copper and DMAP relay‐catalyzed strategy has been achieved for the modular synthesis of 2‐alkoxy quinolines from a three‐component coupling of terminal alkynes, anthranils, and alcohols. In this protocol, a novel quinoline pyridine salt is formed and serves as a key intermediate in the formation of 2‐alkoxy quinolines. The reaction has a broad substrate scope of each reaction partners, affording diversified 2‐alkoxy quinoline products in generally good yields.
Statistical, Bottom‐Up Model for Chemical Diffusion Based on Atomic Vacancy Sublattice Configurations in Layered Lithium Nickel Oxide Cathode Materials
Authors: Olou'ou Guifo Stéphane B. , Mueller Jonathan E. , Markus Torsten 
Published: December 2024

AbstractTo investigate the influence of the local environment on Li‐ion diffusivity in layered lithium nickel oxide (LixNiO2) cathodes, a bottom‐up, multiscale‐modeling approach is applied, utilizing density functional theory (DFT) with corrected Coulomb and van der Waals interactions to describe the energy‐structure relationship of LixNiO2 (x = 0 – 1) in good agreement with previous experiments. The UNiversal CLuster Expansion (UNCLE) is employed to construct high‐probability Li–vacancy configurations and the Nudged Elastic Band (NEB) method to compute energy barriers for representative Li diffusion mechanisms. By fitting a cluster expansion model to these barriers, diffusion barriers are determined for all possible Li–vacancy configurations within a nearest‐neighbor approximation. Based on this description, Li‐concentration‐dependent diffusion coefficients are predicted for the entire Li‐concentration range. For the LixNiO2 crystal lattice, the computed Li chemical diffusivities well lie within experimental ranges, namely 10−11 – 10−8 cm2 s−1, at room temperature with activation energies around 37.9 kJ mol−1. The maximum diffusivity of 4.23 × 10−8 cm2 s−1 is identified at x = 0.63. The new analytical, self‐consistent approach here relies on configurational samplings of individual atomistic mechanisms and can be applied to investigate diffusion properties in further dilute and concentrated alloy systems more efficiently than common numerical procedures.
Revealing the Effect of Solvent Additive Selectivity on Morphology and Formation Kinetics in Printed Non‐fullerene Organic Solar Cells at Ambient Conditions
Authors: Zhang Jinsheng , Li Zerui , Jiang Xinyu , Xie Lin , Pan Guangjiu , Buyan‐Arivjikh Altantulga , Baier Thomas , Tu Suo , Li Lixing , Schwartzkopf Matthias , Vayalil Sarathlal Koyiloth , Roth Stephan V. , Ge Ziyi , Müller‐Buschbaum Peter 
Published: December 2024

AbstractSolvent additives enable the efficient modification of the morphology to improve the power conversion efficiency (PCE) of organic solar cells. However, the impact of solvent additive selectivity on the film morphology and formation kinetics is still unclarified. Herein, this work investigates two solvent additives, 1‐chloronaphthalene (1‐CN) and tetralin, characterized by their varying selectivity for the polymer donor (PBDB‐T‐2F) and the non‐fullerene small molecule acceptor (BTP‐C3‐4F). Specifically, 1‐CN exhibits superior solubility for BTP‐C3‐4F over PBDB‐T‐2F, whereas tetralin shows the opposite trend. The blend films with and without solvent additives are fabricated with the slot‐die coating at ambient conditions. Both solvent additives can promote larger phase separation and increase the size of crystals of the selectively dissolved component. In situ grazing‐incidence wide‐angle X‐ray scattering and UV–vis absorption spectra during printing unveil two distinct kinetic processes induced by 1‐CN and tetralin, leading to large‐sized crystals. 1‐CN can prolong the liquid‐solid phase separation to provide sufficient time for the BTP‐C3‐4F crystal growth but suppress the crystal growth of PBDB‐T‐2F. Tetralin can swell PBDB‐T‐2F and break down BTP‐C3‐4F crystals at the same time. Upon thermal annealing, the oversized crystals triggered by both solvent additives can be optimized to an appropriate size, resulting in an enhanced PCE.
A Deep Intronic Splice Variant in COL1A1 Causing Osteogenesis Imperfecta Type II
Authors: Schouw Mackenna E. , Ruivenkamp Claudia A. L. , Koopmann Tamara T. , Santen Gijs W. E. , Nikkels Peter G. J. , van der Tuin Karin 
Published: December 2024

ABSTRACTOsteogenesis imperfecta (OI) is a rare disease, hallmarked by bone fragility, multiple fractures, and deformities, and is commonly caused by pathogenic variants in the genes encoding type I collagen. Type II OI is the most severe form and is lethal in the perinatal period. Here, we report recurrence of perinatal lethal OI in two fetuses due to parental mosaicism for a deep intronic pathogenic variant at c.2451 + 77C > T in intron 35 of COL1A1, which resulted in aberrant splicing and the in‐frame addition of 75 nucleotides into the mRNA. These patients highlight the importance of considering deep intronic variants in type 1 collagen genes in patients with high suspicion of OI, which may be missed with conventional genetic analysis.
Oxirane‐Driven Cascade Transformations of 5‐Arylidene‐Thiazolidine‐2,4‐Diones
Authors: Simonov Alexander Yu. , Panov Alexey A. , Churakov Andrei V. , Polshakov Vladimir I. , Levshin Igor B. 
Published: December 2024

AbstractThe reaction of thiazolidine‐2,4‐diones (TZDs) with oxiranes has been thoroughly investigated. For the first time, it has been observed that 5‐arylidene‐TZD derivatives can undergo transformation into 6‐substituted 1,4‐oxathian‐2‐ones. Additionally, it has been demonstrated that certain 3‐substituted 5‐arylidene‐TZDs can convert to 1,4‐oxathian‐2‐ones and oxazolidines upon reaction with oxiranes, confirming that the process follows a cascade mechanism. Several factors have been found to influence the reaction‘s outcome, including the amount of oxirane, the presence of a base, and solvent polarity. It has been determined that dimethylformamide (DMF) is essential for the reaction to proceed efficiently. Furthermore, the critical role of the benzylidene group in facilitating the reaction has been confirmed. An unusual hydrogen bond between the ortho‐hydrogens of the phenyl group and the sulfur atom of the thiazolidine ring, observed via NMR spectroscopy, highlights the sulfur atom‘s strong electron‐accepting properties, which play a key role in the observed transformations.
Co‐pathologies modify hippocampal protein accumulation patterns in neurodegenerative diseases
Authors: Yoshida Koji , Forrest Shelley L. , Ichimata Shojiro , Tanaka Hidetomo , Kon Tomoya , Kovacs Gabor G. 
Published: December 2024

AbstractINTRODUCTIONLimited research has extensively analyzed neurodegenerative disease–related protein deposition patterns in the hippocampus.METHODSThis study examined the distribution of proteins in hippocampal subregions across major neurodegenerative diseases and explored their relation to each other. The area density of phosphorylated tau (p‐tau), amyloid beta (Aβ), α‐synuclein, and phosphorylated TDP‐43 protein deposits together with pyramidal cell density in each hippocampal subregion, including CA1‐4, prosubiculum (ProS), and subiculum was assessed in 166 cases encompassing various neurodegenerative diseases.RESULTSAlzheimer's disease‐associated p‐tau predominated in ProS, Aβ in the CA1, and Lewy body–related α‐synuclein in the CA2. The area density of protein deposits increased with the pathological stage until a peak, then decreased in cases with high pathology stages along with pyramidal cell density. Comorbid protein pathology influenced protein deposition patterns.DISCUSSIONThis comprehensive evaluation reveals characteristic neurodegenerative disease–related protein accumulation patterns in hippocampal subregions modified by co‐pathologies.Highlights
Alzheimer's disease–related phosphorylated tau predominates in the prosubiculum.
Amyloid beta predominates in the CA1 and Lewy body–related α‐synuclein in the CA2.
The area density of protein deposition increases with the disease stage up to a peak.
In the high pathology stage, protein deposition and pyramidal cell density decreases.
Comorbid protein pathology affects the pattern of protein accumulation.
Examination of MGMT as a risk gene for dementia in the Amish
Authors: Main Leighanne R. , Song Yeunjoo E. , Lynn Audrey , Laux Renee A. , Miskimen Kristy L. , Osterman Michael D. , Cuccaro Michael L. , Ogrocki Paula K. , Lerner Alan J. , Vance Jeffery M. , Fuzzell M. Denise , Fuzzell Sarada L. , Hochstetler Sherri D. , Dorfsman Daniel A. , Caywood Laura J. , Prough Michael B. , Adams Larry D. , Clouse Jason E. , Herington Sharlene D. , Scott William K. , Pericak‐Vance Margaret A. , Haines Jonathan L. 
Published: December 2024

AbstractINTRODUCTIONRecently, the O‐6‐methylguanine‐DNA methyltransferase (MGMT) locus was proposed as influencing the risk of Alzheimer's disease (AD) in women who did not carry the apolipoprotein E ε4 allele. We examined an Amish founder population for any influence of genetic variation in and around the MGMT locus on the risk for dementia.METHODSGenetic association was performed for single nucleotide polymorphisms (SNPs) surrounding the MGMT locus. A total of 946 individuals of Amish descent between the ages of 76 and 95 who were classified as cognitively impaired or cognitively unimpaired were included. Multiple statistical models were applied to test for replication.RESULTSThe results for the previously associated individual SNPs were not significant. However, a different SNP (rs7909468) generated significant results under a model different from the previous report.DISCUSSIONThe MGMT locus may influence the risk of AD, although its genetic mechanisms remain unclear and warrant further study.Highlights
Association analyses around the O‐6‐methylguanine‐DNA methyltransferase (MGMT) locus showed a study‐significant single nucleotide polymorphism (SNP), rs7909468, in a female cognitively impaired group lacking the apolipoprotein E ε4 genotype.
Functional implications of rs7909468 are relatively unexplored, but in silico analyses indicate it may regulate MGMT expression.
rs7909468 was not in linkage disequilibrium with other SNPs found to be significant in this region and appears as a distinct novel association.
Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis
Authors: Canal‐Garcia Anna , Branca Rui M. , Francis Paul T. , Ballard Clive , Winblad Bengt , Lehtiö Janne , Nilsson Per , Aarsland Dag , Pereira Joana B. , Bereczki Erika 
Published: December 2024

AbstractINTRODUCTIONWe aimed to identify unique proteomic signatures of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD).METHODSWe conducted a comparative proteomic analysis of 33 post mortem brains from AD, DLB, and PDD individuals without dementia focusing on prefrontal, cingulate, and parietal cortices, using weighted gene co‐expression network analyses with differential enrichment analysis.RESULTSNetwork modules revealed hub proteins common to all dementias. Lewy body dementias differed from AD by reduced levels of the autophagy protein p62 (SQSTM1), whereas DLB was distinguished from both AD and PDD by altered TRIM33 and cysteine/glutamate transporter (SLC7A11) across brain regions. An increase in mitochondrial and synaptic proteins was related to better cognition whereas enrichment in the extracellular matrix, complement system, and autophagy proteins was associated with greater cognitive impairment.DISCUSSIONOur study offers valuable insights into the network‐based biomarker characterization of molecular signatures of AD, DLB, and PDD.Highlights
Reduced levels of the autophagy protein p62 (SQSTM1) differentiated Lewy body dementias from Alzheimer's disease (AD) across multiple brain regions.
Dementia with Lewy bodies (DLB) was distinguished from both AD and Parkinson's disease dementia (PDD) by altered TRIM33 and cysteine/glutamate transporter (SLC7A11) levels across brain regions.
Key mitochondrial oxidative phosphorylation proteins (e.g., COX7A2, TOMM40L, NDUFV1), and synaptic proteins (e.g., GABRB3, GABRB2, GLUA3, GLUA4, SNAP47, dynamin1) were more abundant in preserved cognitive states.
Extracellular matrix proteins and members of the complement system (decorin, biglycan, C4A, C4B) showed a strong positive correlation with cognitive decline.