bluuebunny/crossref_metadata_2025_split huggingface dataset:
Right to Life and Capital Punishment in Transnational Judicial Dialogue
Authors: Hsu Jimmy Chia-Shin 
Published: December 2021

AbstractIn this article, I bring the constitutional jurisprudence of major East Asian courts into reconstructive dialogue with that of the United States, South Africa, and several former Soviet-bloc countries, on per se review of capital punishment. This fills in a gap in the literature, which has failed to reflect new developments in Asia. Besides analysing various review approaches, I extrapolate recurrent analytical issues and reconstruct dialogues among these court decisions. Moreover, I place the analysis in historical perspective by periodising the jurisprudential trajectory of the right to life. The contextualised reconstructive dialogues offer multilayered understanding of my central analytical argument: for any court that may conduct per se review of capital punishment in the future, the highly influential South African Makwanyane case does not settle the lesson. The transnational debate has been kept open by the Korean Constitutional Court's decisions, as well as retrospectively by the US cases of Furman and Gregg. This argument has two major points. First, the crucial part of the reasoning in Makwanyane, namely that capital punishment cannot be proven to pass the necessity test under the proportionality review, is analytically inconclusive. The Korean Constitutional Court's decision offers a direct contrast to this point. Second, the exercise of proportionality review of the Makwanyane Court does not attest to the neutrality and objectivity of proportionality review. Rather, what is really dispositive of the outcome are certain value choices inhering in per se review of capital punishment.
The basic income: Initiating the needed discussion in industrial, work, and organizational psychology
Authors: Hüffmeier Joachim , Zacher Hannes 
Published: December 2021

AbstractThe basic income (BI) involves regular and unconditional cash payments to all members of a political community, without the requirement or expectation to work in return. Whereas the BI is increasingly discussed by political parties, organizational practitioners, and in other academic disciplines, the field of industrial, work, and organizational (IWO) psychology has so far remained silent on the concept. In this article, we first explain why there is a growing interest in the BI and outline potential reasons why the BI, despite its topical relevance, has not been discussed by IWO psychologists. Next, to initiate the needed discussion on the BI, we outline the most important background information on the concept, including its definition, history, financial aspects, main criticisms, and potential advantages. We further provide first answers to common questions about the BI from an IWO psychology perspective, such as “(Why) would people still work if they received a BI?” We conclude with a discussion of potential positive and negative consequences of the BI as well implications for future theory development, empirical research, and practical applications.
A novel speed optimisation scheme for unmanned sailboats by sliding mode extremum seeking control without steady-state oscillation
Authors: Shen Zhipeng , Fan Xuechun , Yu Haomiao , Guo Chen , Wang Saisai 
Published: December 2021

AbstractThis paper proposes a novel speed optimisation scheme for unmanned sailboats by sliding mode extremum seeking control (SMESC) without steady-state oscillation. In the sailing speed optimisation scheme, an initial sail angle of attack is first computed by a piecewise constant function in the feed forward block, which ensures a small deviation between sailing speed and the maximum speed. Second, the sailing speed approaches to maximum gradually by extremum search control (ESC) in the feedback block. In SMESC without steady-state oscillation, a switching law is designed to carry out the control transformation, so that the speed optimisation system carries out SMESC in the first convergence phase and ESC without steady-state oscillation in the second stability phase. This scheme combines the advantages of both control algorithms to maintain a faster convergence rate and to eliminate steady-state oscillation. Furthermore, the strict stability of the speed optimisation system is proved in this paper. Finally, we test a 12-m mathematical model of an unmanned sailboat in the simulation to demonstrate the effectiveness and robustness of this speed optimisation scheme.
A filter algorithm for receiver tracking loops assisted by inertial information
Authors: Han Zhifeng , Fang Zheng 
Published: December 2021

AbstractIn traditional satellite navigation receivers, the parameters of tracking loop such as loop bandwidth and integration time are usually set in the design of the receivers according to different scenarios. The signal tracking performance is limited in traditional receivers. In addition, when the tracking ability of weak signals is improved by extending the integration time, negative effect of residual frequency error becomes more and more serious with extension of the integration time. To solve these problems, this paper presents out research on receiver tracking algorithms and proposes an optimised tracking algorithm with inertial information. The receiver loop filter is designed based on Kalman filter, reducing the phase jitter caused by thermal noise in the weak signal environment and improving the signal tracking sensitivity. To confirm the feasibility of the proposed algorithm, simulation tests are conducted.
OPINIONS ON THE LOWLAND MAYA LATE ARCHAIC PERIOD WITH SOME EVIDENCE FROM NORTHERN BELIZE
Authors: Rosenswig Robert M. 
Published: December 2021

AbstractThe fourth millennium b.p. in the Maya lowlands provides an interesting case, with mobile, aceramic peoples documented, while ceramic-using villagers lived in other parts of Mesoamerica. Rather than ask why ceramic containers and village life took so long to reach the Maya lowlands, the question can be inverted to posit that a mixed horticultural-foraging adaptation was so effective that it persisted longer than elsewhere. I propose that the so-called 4.2 ka b.p. event was the ultimate cause of increased sedentism and the first adoption of ceramic containers in a limited number of regions of Mesoamerica. My musings are grounded in the comparisons of data from the Soconusco region of southern Mexico and evidence from northern Belize at Colha and Pulltrouser Swamp, as well as the Freshwater Creek drainage. I assume that proximate behavior must account for local adaptations and different rates of change in each region of Mesoamerica. Therefore, regional adaptation in northern Belize during the Late Archaic period provides the evidence with which to reconstruct local adaptation. Excavations and regional reconnaissance document a distinctive orange soil horizon at Progresso Lagoon associated with patinated chert tools and an absence of ceramics. Stone tool assemblages from the preceramic components of three sites in the region indicate a spatial separation of tool use and resharpening at island versus shore. Starch grains recovered from these stone tools indicate that preceramic peoples in northern Belize harvested maize and several other domesticated plant species. These data are consistent with local paleoenvironmental studies that document an extended period of horticultural activity during the fifth and fourth millennia b.p. prior to the adoption of ceramics. Lithic assemblages and associated dietary information from multiple sites provide glimpses of the data necessary to reconstruct Late Archaic period adaptation from a single locale. Such data will be required to understand the proximate causes for the transition to a more settled, village life.
Self-conscious intelligent technological societies in the universe: a simple direct approach to probable astrosociological realistic scenarios
Authors: da Silva L. A. L. 
Published: December 2021

AbstractWe present an alternative equation to estimate the probable numberNof self-conscious intelligent technological societies (SCITSs) within the radius of the observable universe. This equation has only one poorly-known factor,Pc, the SCITS's formation probability, which can be estimated within an uncertainty by a factor of 102(10−11≤Pc≤ 10−9) by applying the restriction imposed by Fermi's Paradox. The SCITS's formation rate for a typical spiral galaxy is then estimated as ≈1 civ Gyr−1. For a very optimistic maximum life expectancy ≈108yr, the conclusion is that two civilizations never coexist in the same galaxy. Our estimated values forPcare compatible with current biological and astrophysical evidences. We also propose an alternative astrosociological classification scheme which enables us to speculate about possible evolutionary paths for SCITSs in the universe. The so-called ‘Closed Bottle Neck’ (CBN) scenario suggests that civilizations are no exit evolutionary ways. We argue that simply there would not be interstellar travels nor Galaxy colonization or a Galactic Club. Thus Fermi's Paradox results eliminated, and the perspectives about the future of our own civilization may not be positive.
New Insights Into Crustal Properties of Anatolia and Its Surroundings Inferred From P‐Coda Autocorrelation Inversions
Authors: Eken Tuna , Tork Qashqai Mehdi , Schiffer Christian , Taymaz Tuncay , Saygin Erdinc 
Published: December 2021

AbstractConstraints on crustal and uppermost mantle structure provide key information for understanding the geodynamic processes that have shaped the geological expressions and are currently causing deformation in Anatolia. We apply a novel method of Bayesian inversion of autocorrelated teleseismic P‐wave coda data to retrieve the crustal and uppermost mantle structures beneath Anatolia and southeast Europe. Our inversion provides estimates of Moho depth variations and crustal velocity structure (e.g., Vp, Vs, and Vp/Vs ratio). The Moho architecture in the study area can be summarized by (a) an overall west‐to‐east increase in the Moho depth from Greece to eastern Anatolia, (b) a homogeneously thin crustal structure beneath Greece, (c) complex, small‐scale crustal features and variations in western and central Anatolia, and (d) relatively long‐wavelength variations, but overall thick crust in eastern Anatolia. The apparent relation between the Moho depth variations and suture/fault zones implies a dominant control of structural inheritance on the past deformation in Anatolia. The overall Moho architecture appears to correlate well with the topography in Anatolia, although with some exceptions, in particular at smaller wavelength. These local inconsistencies in the topography‐Moho depth relation suggest a more complex, wavelength‐dependent isostatic state compared to what is expected from simple Airy isostasy. The observed deviations may originate from elastic effects, lithospheric density changes, or sub‐lithospheric dynamic effects. Obvious large lateral variations in Vp, Vs and Vp/Vs ratio estimates in our model can relate to such density variations within the crust especially between tectonic domains.
Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium
Authors: Zhang Yong , Chen Jiayao , Fu Haijun , Kuang Shuhong , He Feng , Zhang Min , Shen Zongshan , Qin Wei , Lin Zhengmei , Huang Shuheng 
Published: December 2021

AbstractAlthough mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, have hampered their clinical application. These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system. However, the potential function of MSC-exos produced by 3D culture (3D-exos) in periodontitis remains elusive. This study showed that compared with MSC-exos generated via 2D culture (2D-exos), 3D-exos showed enhanced anti-inflammatory effects in a ligature-induced model of periodontitis by restoring the reactive T helper 17 (Th17) cell/Treg balance in inflamed periodontal tissues. Mechanistically, 3D-exos exhibited greater enrichment of miR-1246, which can suppress the expression of Nfat5, a key factor that mediates Th17 cell polarization in a sequence-dependent manner. Furthermore, we found that recovery of the Th17 cell/Treg balance in the inflamed periodontium by the local injection of 3D-exos attenuated experimental colitis. Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis, the 3D culture system improved the function of MSC-exos in the treatment of periodontitis, but also it provided a basis for treating inflammatory bowel disease (IBD) by restoring immune responses in the inflamed periodontium.
Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis
Authors: Zhuang Jingshen , Chen Xuebing , Cai Guixing , Wu Dizheng , Tu Chen , Zhu Siyuan , Huang Yusheng , Xu Ping , Zhong Zhaoming 
Published: December 2021

AbstractEnhanced osteoclastogenesis is one of the major causes of age-related bone loss. Aging is accompanied by accumulation of advanced oxidation protein products (AOPPs). However, whether AOPPs accumulation contributing to the osteoclastogenesis with aging remains unclear. Here, we showed that AOPPs accumulation was associated with the enhanced osteoclastogenesis and deterioration of bone microstructure in aged mice. In vitro, AOPPs directly induced osteoclastogenesis by interaction with receptor activator of nuclear factor κ B (RANK) and the receptor for advanced glycation end products (RAGE) in the primary bone marrow monocytes. Bindings of AOPPs to RANK and RAGE were able to activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, trigger generation of reactive oxygen species, then induce phosphorylation of mitogen-activated protein kinases and c-fos, upregulation of the nuclear factor of activated T cell c1, eventually induce bone marrow monocytes to differentiate into mature osteoclasts. Chronic exposure to AOPPs enhanced osteoclastogenesis and bone loss in mice, which could be alleviated by NADPH oxidase inhibitor apocynin. Local injection of AOPPs into subperiosteal area induced bone resorption at the site of administration, which was similar to the effect of RANK ligand. Together, these results suggested that AOPPs could serve as a novel regulator of osteoclastogenesis and AOPPs accumulation might play an important role in the development of age-related bone loss.
TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia
Authors: Zhang Yahui , Hou Baohua , Liang Peiyu , Lu Xin , Wu Yifan , Zhang Xinyi , Fan Yuanteng , Liu Yumin , Chen Taoxiang , Liu Wanhong , Peng Biwen , Yin Jun , Han Song , He Xiaohua 
Published: December 2021

AbstractMultiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS. However, the underlying mechanism of NLRP3 inflammasome activation is not fully understood. Here we identified that the TRPV1 (transient receptor potential vanilloid type 1) channel in microglia, as a Ca2+ influx-regulating channel, played an important role in NLRP3 inflammasome activation. Deletion or pharmacological blockade of TRPV1 inhibited NLRP3 inflammasome activation in microglia in vitro. Further research revealed that TRPV1 channel regulated ATP-induced NLRP3 inflammasome activation through mediating Ca2+ influx and phosphorylation of phosphatase PP2A in microglia. In addition, TRPV1 deletion could alleviate mice experimental autoimmune encephalomyelitis (EAE) and reduce neuroinflammation by inhibiting NLRP3 inflammasome activation. These data suggested that the TRPV1 channel in microglia can regulate NLRP3 inflammasome activation and consequently mediate neuroinflammation. Meanwhile, our study indicated that TRPV1–Ca2+–PP2A pathway may be a novel regulator of NLRP3 inflammasome activation, pointing to TRPV1 as a potential target for CNS inflammatory diseases.
Aldehyde dehydrogenase 3B2 promotes the proliferation and invasion of cholangiocarcinoma by increasing Integrin Beta 1 expression
Authors: Wang Yue , Li Kangshuai , Zhao Wei , Liu Zengli , Liu Jialiang , Shi Anda , Chen Tianli , Mu Wentao , Xu Yunfei , Pan Chang , Zhang Zongli 
Published: December 2021

AbstractAldehyde dehydrogenases (ALDHs) play an essential role in regulating malignant tumor progression; however, their role in cholangiocarcinoma (CCA) has not been elucidated. We analyzed the expression of ALDHs in 8 paired tumor and peritumor perihilar cholangiocarcinoma (pCCA) tissues and found that ALDH3B1 and ALDH3B2 were upregulated in tumor tissues. Further survival analysis in intrahepatic cholangiocarcinoma (iCCA, n = 27), pCCA (n = 87) and distal cholangiocarcinoma (dCCA, n = 80) cohorts have revealed that ALDH3B2 was a prognostic factor of CCA and was an independent prognostic factor of iCCA and pCCA. ALDH3B2 expression was associated with serum CEA in iCCA and dCCA, associated with tumor T stage, M stage, neural invasion and serum CA19-9 in pCCA. In two cholangiocarcinoma cell lines, overexpression of ALDH3B2 promoted cell proliferation and clone formation by promoting the G1/S phase transition. Knockdown of ALDH3B2 inhibited cell migration, invasion, and EMT in vitro, and restrained tumor metastasis in vivo. Patients with high expression of ALDH3B2 also have high expression of ITGB1 in iCCA, pCCA, and dCCA at both mRNA and protein levels. Knockdown of ALDH3B2 downregulated the expression of ITGB1 and inhibited the phosphorylation level of c-Jun, p38, and ERK. Meanwhile, knockdown of ITGB1 inhibited the promoting effect of ALDH3B2 overexpression on cell proliferation, migration, and invasion. ITGB1 is also a prognostic factor of iCCA, pCCA, and dCCA and double-positive expression of ITGB1 and ALDH3B2 exhibits better performance in predicting patient prognosis. In conclusion, ALDH3B2 promotes tumor proliferation and metastasis in CCA by regulating the expression of ITGB1 and upregulating its downstream signaling pathway. The double-positive expression of ITGB1 and ALDH3B2 serves as a better prognostic biomarker of CCA.
SYT8 promotes pancreatic cancer progression via the TNNI2/ERRα/SIRT1 signaling pathway
Authors: Fu Zhiping , Liang Xing , Shi Ligang , Tang Liang , Chen Danlei , Liu Anan , Shao Chenghao 
Published: December 2021

AbstractPancreatic cancer is a highly lethal malignancy due to failures of early detection and high metastasis in patients. While certain genetic mutations in tumors are associated with severity, the molecular mechanisms responsible for cancer progression are still poorly understood. Synaptotagmin-8 (SYT8) is a membrane protein that regulates hormone secretion and neurotransmission, and its expression is positively regulated by the promoter of the insulin gene in pancreatic islet cells. In this study, we identified a previously unknown role of SYT8 in altering tumor characteristics in pancreatic cancer. SYT8 levels were upregulated in patient tumors and contributed towards increased cell proliferation, migration, and invasion in vitro and in vivo. Increased SYT8 expression also promoted tumor metastasis in an in vivo tumor metastasis model. Furthermore, we showed that SYT8-mediated increase in tumorigenicity was regulated by SIRT1, a protein deacetylase previously known to alter cell metabolism in pancreatic lesions. SIRT1 expression was altered by orphan nuclear receptor ERRα and troponin-1 (TNNI2), resulting in cell proliferation and migration in an SYT8-dependent manner. Together, we identified SYT8 to be a central regulator of tumor progression involving signaling via the SIRT1, ERRα, and TNNI2 axis. This knowledge may provide the basis for the development of therapeutic strategies to restrict tumor metastasis in pancreatic cancer.
LncRNA LINC00667 aggravates the progression of hepatocellular carcinoma by regulating androgen receptor expression as a miRNA-130a-3p sponge
Authors: Qin Zhixiang , Liu Xiaohong , Li Zijing , Wang Ganggang , Feng Zhe , Liu Ye , Yang Hai , Tan Chengpeng , Zhang Zidong , Li Kun 
Published: December 2021

AbstractEmerging studies have found long noncoding RNAs, widely expressed in eukaryotes, crucial regulators in the progression of human cancers, including hepatocellular carcinoma (HCC). Although the long intergenic noncoding RNA 667 (LINC00667) can promote the progression of a variety of cancer types, the expression pattern, the role in cancer progression, and the molecular mechanism involved in HCC remain unclear. This study aims to investigate the function and mechanism of LINC00667 in HCC progression. The effects of LINC00667 silencing in cell proliferation, cell migration, and cell invasion, and androgen receptor (AR) expression were determined with loss-of-function phenotypic analysis in Huh-7 and HCCLM3 cells, and subsequently testified in vivo in tumor growth. We found that the expression of LINC00667 was upregulated in HCC tissues and cell lines. Upregulation of LINC00667 was significantly associated with the unfavorable prognosis of HCC in our study patients. On the other hand, low expression of LINC00667 significantly inhibited the cell proliferation, cell migration and cell invasion of HCC in vitro and tumor growth in vivo. This inhibitory effect could be counteracted by miR-130a-3p inhibitor. LINC00667 reduced the inhibition of AR expression by miR-130a-3p, which correlated with the progression of HCC. Our finding suggests LINC00667 is a molecular sponge in the miR-130s-3p/AR signal pathway in the progression of HCC, in which it relieves the repressive function of miR-130a-3p on the AR expression. This indicates LINC00667 functions as a tumor promotor in promoting HCC progression through targeting miR-130a-3p/AR axis, making a novel biomarker and potential therapeutic target for HCC.
Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics
Authors: Darrous Liza , Mounier Ninon , Kutalik Zoltán 
Published: December 2021

AbstractMendelian Randomisation (MR) is an increasingly popular approach that estimates the causal effect of risk factors on complex human traits. While it has seen several extensions that relax its basic assumptions, most suffer from two major limitations; their under-exploitation of genome-wide markers, and sensitivity to the presence of a heritable confounder of the exposure-outcome relationship. To overcome these limitations, we propose a Latent Heritable Confounder MR (LHC-MR) method applicable to association summary statistics, which estimates bi-directional causal effects, direct heritabilities, and confounder effects while accounting for sample overlap. We demonstrate that LHC-MR outperforms several existing MR methods in a wide range of simulation settings and apply it to summary statistics of 13 complex traits. Besides several concordant results with other MR methods, LHC-MR unravels new mechanisms (how disease diagnosis might lead to improved lifestyle) and reveals new causal effects (e.g. HDL cholesterol being protective against high systolic blood pressure), hidden from standard MR methods due to a heritable confounder of opposite effect direction.