bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing US Registered Dietitians Knowledge and Perceptions of a Gluten-Free Diet: A Mixed Methods Approach
Authors: Brannan Robert G. , Helton Hannah , Beverly Elizabeth A. , Murray Deborah , Russell Melissa 
Published: March 2021

Abstract
Background The practice of gluten-free diets is on the rise, evidenced by the increase in gluten-free sales from $2.8 billion in 2015 to a projected $7.6 billion in 2020. People with celiac disease and non-celiac gluten sensitivity are required to avoid gluten containing products. It is important that registered dietitians are knowledgeable about this topic due to the prevalence and popularity of the gluten-free diet by those with or without celiac disease or non-celiac gluten sensitivity. Methods A mixed methods approach using qualitative (focus group) was used to generate topics for a quantitative (survey) that assessed knowledge and perceptions of a gluten-free diet from a representative sample of 508 registered dietitians.ResultsOver 18% of respondents incorrectly identified gluten as a carbohydrate. Additionally, less than 80% of RDs correctly identified the presence or absence of gluten in semolina, spelt, kamut, and buckwheat. Regarding perceptions of a gluten-free diet, participants reported that the public is not aware of what gluten is, a gluten-free diet is not appropriate for the general public or weight loss, and the gluten-free diet is a fad when used outside of celiac disease and nonceliac gluten sensitivity.ConclusionsThere is a need for improved education of a gluten-free diet in the areas of sources of gluten, labeling, and gluten-related disorders among Registered Dietitians.
The sensitivity and specificity of the total prostate specific antigen test in prostate cancer screening: A Short report
Authors: Banyeh Moses , Zogli Kervin Edinam 
Published: March 2021

Abstract
Objective: The total prostate specific antigen (TPSA) test is still widely used in Ghana for PCa screening due to its simplicity and logistical challenges in the healthcare sector. This study aimed to determine the sensitivity and specificity of TPSA in PCa screening in Ghana. Results: This was a cross-sectional study that was conducted at the Department of Urology of the Komfo Anokye Teaching Hospital between January 2018 and December 2019. The study involved 69 male patients with histologically confirmed BPH or PCa. The study population was between 45 to 104 years. BPH patients constituted 74% (51/69) while 26% (18/69) were PCa patients. Venous blood samples were collected before the prostate examination and analysed for TPSA. The BPH group was statistically compared with the PCa group in terms of age and TPSA levels. The TPSA was significantly elevated in PCa (P=0.001). Univariate [OR: 8.684(1.757-42.927)] and multivariate [aOR:10.544(2.001-55.562)] analysis showed that TPSA was positively associated with PCa; but this association was only moderate (AUC:0.78, P<0.001) with a sensitivity of 83.3%, specificity 64.0% at a cut-off value of 20.0ng/ml. The TPSA test has only moderate performance in PCa screening and should always be complemented by a second screening test.
SWalker: a robotic platform for hip fracture rehabilitation
Authors: Costa Vanina , Ramírez Óscar , Perea Luis , Velásquez Alexánder , Otero Abraham , Rocon Eduardo , Raya Rafael 
Published: March 2021

Abstract
BackgroundHip fracture is one of the most common traumatisms associated with falls in the elderly, severely affecting the patient's mobility and independence. The treatment involves hospitalization and prolonged rehabilitation periods with high costs which are associated with an increased mortality rate due to health complications. In recent years, the use of robotic applications has proven to be effective in gait rehabilitation, especially for neurological disorders. However, there is a lack of research in robotic rehabilitation focused on hip fracture of elderly people. This paper presents the design and validation of a novel robotic platform for hip rehabilitation called SWalker aimed at improving the rehabilitation of this condition.MethodsThe performance of the SWalker platform was assessed at Albertia Servicios Sociosanitarios S.A. nursing homes. Preliminary functional validation of the SWalker platform was carried out with five healthy elderly subjects and two physiotherapists. Clinical validation was conducted with 34 hip fracture patients. The control group (n = 24, age = 86.38 ± 6.16, 75% female) followed conventional therapy, while the intervention group (n = 10, age = 86.80 ± 6.32, 90% female) was rehabilitated using SWalker. Physiological parameters, and functional assessment scales such as FAC and Tinetti were collected at the beginning and at the end of the intervention. Gait recovery and rehabilitation process indicators were also gathered.ResultsSWalker had a good acceptability in the functional validation (final scores > 85), as measured by the System Usability Scale. In the clinical validation, the control group required 68.09 ± 27.38 rehabilitation sessions compared to 22.60 ± 16.75 in the intervention group (p < 0.001). Patients in the control group needed 120.33 ± 53.64 days to reach ambulation, while patients rehabilitated with SWalker achieved that stage in 67.11 ± 51.07 days (p = 0.021). FAC and Tinetti indexes presented a larger improvement in the intervention group when compared with the control group (p = 0.007 and p = 0.01, respectively).ConclusionsThe SWalker platform can be considered an effective tool to enhance autonomous gait and shorten rehabilitation therapy in elderly hip fracture patients. This result encourages further research on robotic rehabilitation platforms for hip fracture.Trial registrationThis study was performed under the protocol “SWALKERS17”, approved on January 15, 2019 by the Local Ethical Committee of Fundación Jiménez Díaz. Public trial registration ISRCTN28049001 on February, 25 – Retrospectively registered, https://www.isrctn.com/ISRCTN28049001.
Combination of Na-Ca-phosphate and fluorapatite in wollastonite-diopside glass-ceramic: degradation and biocompatibility
Authors: Mahdy Ebrahim A. , Ahmed Hanaa Y. , Farag Mohammad 
Published: March 2021

Abstract
In this study, we investigated the effect of introducing sodium calcium phosphate (NCP), fluorapatite (FA), or the combination of both phases in the wollastonite-diopside (WD) bioactive glass-ceramic system on the crystalline phases formed, microstructure, degradation, and biocompatibility of those materials. The prepared materials were characterized by DTA, XRD, and SEM/EDX. Moreover, the density was measured via Archimede’s method, and the mechanical properties were measured by Vicker’s microhardness indenter. The in vitro bioactivity test was carried out in the simulated body fluid (SBF), and the cell viability test was evaluated using the Vero cells. The results showed that the formed crystalline phases were close to the starting proposed phases. Moreover, NCP-containing WD glass-ceramic was showed the lowest density value due to its low densification, and accordingly, it showed the lowest Vicker`s microhardness value due to the same reason. Furthermore, combining sodium calcium phosphate in WD glass-ceramic was increased cell viability better than that included fluorapatite, whereas, the combination of both crystalline phases in WD glass-ceramic led to an increase in the cytotoxicity to the highest value. In conclusion, different properties of wollastonite-diopside glass-ceramics can be tailored by the combination of NCP or FA, and hence, these glass-ceramic materials can be modified effectively according to the purpose for which it is intended to be applied. The obtained results indicated that different properties of WD glass-ceramic materials can be tailored by the combination of NCP and/or FA. Hence, these glass-ceramics are expected to be useful materials in promising biomedical applications, such as orthopedics and dentistry.
Methods to support evidence-informed decision-making in the midst of COVID-19: Creation and evolution of a rapid review service from the National Collaborating Centre for Methods and Tools
Authors: Neil-Sztramko Sarah E. , Belita Emily , Traynor Robyn L. , Clark Emily , Hagerman Leah , Dobbins Maureen 
Published: March 2021

Abstract
The COVID-19 public health crisis has produced an immense and quickly evolving body of evidence. This research speed and volume, along with variability in quality, could overwhelm public health decision-makers striving to make timely decisions based on the best available evidence. In response to this challenge, the National Collaborating Centre for Methods and Tools developed a Rapid Evidence Service, building on internationally accepted rapid review methodologies, to address priority COVID-19 public health questions. Each week, we receive requests from public health decision-makers and frame the prioritized topics into searchable questions. We develop and conduct a comprehensive search strategy and critically appraise all relevant evidence using validated tools. We synthesize the findings into a final report that includes key messages, with a rating of the certainty of the evidence using GRADE, as well as an overview of evidence and remaining knowledge gaps. Rapid reviews are typically completed and disseminated within one to two weeks. As of February 25, 2021, we have answered more than 27 distinct questions and completed 21 updates as new evidence emerged. The overview of our process, presented here, provides a real-world example of how review-level evidence can be made available – rapidly and rigorously, and in response to decision-makers’ needs – during an unprecedented public health crisis.
The Effects of PDE Inhibitors on Multiple Sclerosis: a Review of in vitro and in vivo Models
Authors: Ainatzoglou Alexandra , Stamoula Eleni , Dardalas Ioannis , Siafis Spyridon , Papazisis Georgios 
Published: March 2021

Background:
Multiple sclerosis (MS) is a chronic inflammatory and immune-mediated disease,
whose current therapeutic means are mostly effective in the relapsing-remitting form of MS, where inflammation
is still prominent, but fall short of preventing long term impairment. However, apart from inflammationmediated
demyelination, autoimmune mechanisms play a major role in MS pathophysiology, constituting a
promising pharmacological target. Phosphodiesterase (PDE) inhibitors have been approved for clinical use in
psoriasis and have undergone trials suggesting their neuroprotective effects, rendering them eligible as an option
for accessory MS therapy.

Objective:
In this review, we discuss the potential role of PDE inhibitors as a complementary MS therapy.

Methods:
We conducted a literature search through which we screened and comparatively assessed papers on
the effects of PDE inhibitor use, both in vitro and in animal models of MS, taking into account a number of inclusion
and exclusion criteria.

Results:
In vitro studies indicated that PDE inhibitors promote remyelination and axonal sustenance, while curbing inflammatory cell infiltration, hindering oligodendrocyte and neuronal loss and suppressing cytokine production. In vivo studies underlined that these agents alleviate symptoms and reduce disease scores in MS animal models.

Conclusion:
PDE inhibitors proved to be effective in addressing various aspects of MS pathogenesis both in
vitro and in vivo models. Given the latest clinical trials proving that the PDE4 inhibitor Ibudilast exerts neuroprotective
effects in patients with progressive MS, research on this field should be intensified and selective
PDE4 inhibitors with enhanced safety features should be seriously considered as prospective complementary
MS therapy.
PENERAPAN ALGORITMA GREEDY UNTUK MENENTUKAN RUTE TERPENDEK ANTAR KLINIK GIGI
Authors: Furqan Muhammad , Nasution Yusuf Ramadhan , Nurdianti Taing Sapitri 
Published: March 2021

<p class="s11"><span class="s17"><span class="bumpedFont15">Kesehatan gigi dan mulut adalah indikator kesehatan masyarakat. Adanya masalah kesehatan pada gigi dan mulut menyebabkan penurunan fungsi kesehatan individu. Masalah kesehatan gigi dan mulut disebabkan oleh kebiasaan seseorang menyikat gigi secara tidak teratur. Banyak pilihan yang dapat dibuat untuk sampai ke lokasi di mana klinik gigi terdekat diinginkan, tetapi ada keadaan di mana klinik gigi yang direncanakan tidak buka. Oleh karena itu dibutuhkan rute terpendek untuk sampai ke klinik gigi lain. Data dalam bentuk jarak, waktu dan rute untuk sampai ke klinik gigi yang diinginkan diambil dari peta </span></span><span class="s18"><span class="bumpedFont15">Google</span></span><span class="s17"><span class="bumpedFont15">, dengan total 10 simpul untuk diterapkan ke peta (</span></span><span class="s18"><span class="bumpedFont15">maps</span></span><span class="s17"><span class="bumpedFont15">). Untuk hasil peta, sebuah algoritma digunakan, dalam hal ini algoritma </span></span><span class="s18"><span class="bumpedFont15">Greedy</span></span><span class="s17"><span class="bumpedFont15"> </span></span><span class="s17"><span class="bumpedFont15">digunakan untuk memecahkan masalah menemukan rute terpendek. Berdasarkan hasil penelitian dari klinik gigi terdekat dengan titik awal yang dicari menggunakan algoritma </span></span><span class="s18"><span class="bumpedFont15">Greedy</span></span><span class="s17"><span class="bumpedFont15"> itu menghasilkan total jarak, waktu perjalanan dan titik yang dilalui.</span></span></p>
A commentary on the value of hospital data for covid-19 pandemic surveillance and planning
Authors: Manuel Douglas G. , Van Walraven Carl , Forster Alan J. 
Published: March 2021

Hospital data for covid-19 surveillance, planning and modelling are challenging to find worldwide in public aggregation portals.
Detailed covid-19 hospital data provides insights into covid-19’s health burden including identifying which sociodemographic groups are at greatest risk of covid-19 morbidity and mortality. Timely hospital data is the best source of information for actionable forecasts and projection models of hospital capacity, including critical resources such as intensive care unit beds and ventilators that take time to plan or procure.
A challenge to generate timely and detailed hospital data is the reliance on separation or discharge abstracts and census counts. What are needed are well-maintained lists of patients hospitalized with covid-19.
From the standpoint of public health and health services researchers and practitioners, we describe the role of hospital data for studying covid-19, why admission data are hard to find, and how improved data infrastructure can meet surveillance and planning needs in the near future. Modern hospital electronic health records can create covid-19 patient lists and these decision support tools are increasingly used for research. These tools can generate patient lists that are transmitted and combined with public health data systems.
Representasi Budaya Termarginalisasi dalam Game
Authors: Yonathan Orville , Paramita Sinta 
Published: March 2021

Games as a form of mass communication carry messages for the audience. One of the games called marginalization was Player Unknown's Battlegrounds (PUBG). This study aims to identify the existence of marginalization in minority cultures in the PUBG game. The PUBG game is a survival game against 100 people where the players are placed on an island. How to survive is done by killing opposing players using the weapons that have been provided. This game can be done alone or in groups of four. The research method used by researchers is qualitative research methods. The research technique used is the Semiotic analysis of Roland Barthes. The data collection technique used was the observation technique. Observations made by researchers include how the characters in this game are made and how the forms of communication performed by the players while playing so that the marginalization of the minority culture appears. This study found that in an online game it has the potential to bring bad things to the intercultural society which is described by Roland Barthes that a bad habit will become a habit that is tolerated.Permainan atau game sebagai bentuk komunikasi massa membawa pesan bagi audiens. Salah satu game yang disebut melakukan marginalisasi adalah game PlayerUnknown’s Battlegrounds (PUBG). Penelitian ini ingin mengidentifikasi adanya marginalisasi pada budaya minoritas dalam game PUBG. Permainan PUBG merupakan permainan bertahan hidup dengan melawan 100 orang di mana para pemainnya ditempatkan di sebuah pulau. Cara bertahan hidup dilakukan dengan membunuh pemain lawan menggunakan senjata yang sudah disediakan. Permainan ini dapat dilakukan sendiri atau berkelompok dengan anggota empat orang. Metode penelitian yang dipakai peneliti adalah metode penelitian kualitatif. Teknik penelitian yang digunakan adalah analisis Semiotika Roland Barthes. Teknik pengumpulan data yang digunakan adalah teknik observasi. Pengamatan yang dilakukan peneliti meliputi bagaimana karakter dalam game ini dibuat dan bagaimana bentuk komunikasi yang dilakukan para pemain pada saat bermain sehingga muncul marginalisasi budaya minoritas tersebut. Penelitian ini menemukan bahwa di dalam sebuah game online memiliki potensi memunculkan hal buruk untuk masyarakat antar budaya yang digambarkan menurut Roland Barthes bahwa sebuah kebiasaan buruk akan menjadi suatu kebiasaan yang ditoleransi.
Komunikasi Pemasaran UMKM dalam Beradaptasi di Masa Pandemi Covid-19 (Studi Kasus Hello Cafe)
Authors: Ambar Ruth , Sari Wulan Purnama 
Published: March 2021

Since the pandemic outbreak hit Indonesia, the most visible impact is the economic crisis. One of those affected was that UMKM (Micro, Small and Medium Enterprises) both in the service and production sectors experienced a significant decline in turnover, one of which is Hello Cafe. Hello Cafe will adapt to new circumstances, where business premises can reopen by complying with existing health protocols. Hello Cafe must be able to carry out proper marketing communications so that customers can come back to visit to improve their turnover and losses. The purpose of this research is to find, understand, and describe what marketing communications will be used appropriately at Hello Cafe to adapt to the covid-19 pandemic. Researchers chose to use a qualitative approach because they will conduct research and analysis on the phenomenon of marketing communication at Hello Cafe during the Covid-19 pandemic. The conclusion of this study is that effective marketing communication in adapting during the Covid-19 pandemic is personal selling to invite old customers to come back to Hello Cafe and word of mouth because most visitors come from recommendations from old customers who have visited.Sejak wabah pandemi melanda Indonesia, dampak yang sangat terlihat adalah krisisnya perekonomian. Salah satu yang terkena dampaknya adalah UMKM (Usaha Mikro Kecil dan Menengah) baik dalam bidang jasa maupun produksi megalami penurunan omzet yang siginifikan, salah satunya adalah Hello Cafe. Hello Cafe akan beradaptasi dengan keadaan yang baru, dimana tempat usaha bisa kembali buka dengan mematuhi protokol kesehatan yang ada. Hello Cafe harus bisa melakukan komunikasi pemasaran yang tepat agar pelanggan dapat kembali berkunjung untuk memperbaiki omzet dan kerugian yang dialami. Tujuan penilitian ini adalah untuk menemukan, memahami, serta mendeskripsikan tentang komunikasi pemasaran apa yang akan digunakan secara tepat pada Hello Cafe untuk beradaptasi di masa pandemi covid-19. Peneliti memilih menggunakan pendekatan kualitatif karena akan melakukan riset dan analisis terhadap fenomena komunikasi pemasaran pada Hello Cafe dalam masa pandemi covid-19. Kesimpulan dari penelitian ini bahwa komunikasi pemasaran yang efektif dalam beradaptasi di masa pandemi covid-19 adalah personal selling untuk mengajak pelanggan lama kembali berkunjung ke Hello Cafe dan word of mouth karena kebanyakan pengunjung berdatangan dari rekomendasi pelanggan lama yang sudah berkunjung.
RANCANG BANGUN SARUNG TANGAN SEBAGAI ALAT BANTU TUNA NETRA BERBASIS SENSOR ULTRASONIC DAN ARDUINO NANO
Authors: Ramadhana Rahmat 
Published: March 2021

Aksesibilitas adalah desain sebuah bangunan yang menjamin keamanan dan mudah dijangkau oleh semua orang dan tidak terkecuali, termasuk individu dengan disabilitas. Salah satu bentuk aksesibilitas adalah adanya guiding block atau ubin tekstur pemandu yang menjadi penunjuk jalan bagi pejalan kaki tunaneta di tempat umum. Akan tetapi guilding block yang sudah ada terkadang membuat penyadang tuna netra mengalami kecelakaan seperti tertabrak pot atapun tiang listrik.
Pada saat ini, alat untuk membantu penyandang tuna netra untuk melakukan aktivitas hanyalah sebuah tongkat yang memiliki panjang 120 cm, Tongkat tersebut memiliki keterbatasan seperti jangkauan alat, tidak dapat mendeteksi berbagai object di sekeliling penyandang dalam waktu yang cepat.
Pada penelitian ini akan dibuat sebuah alat berupa sarung tangan untuk membantu dan meringankan aktivitas seperti mengetahui object yang berada di depan para penyandang tuna netra tersebut. Dengan bantuan sensor ultrasonic kemudian di proses menggunakan Arduino nano. Dengan keluaran menghasilkan getaran dan suara yang berasal dari motor dc dan buzzer. Dapat memberitahukan seberapa dekat objek.
Hasil pengujian yang dilakukan sebanyak sepuluh kali dalam hal jarak dan delay pada tiga kondisi. Sarung tangan memiliki error yang kecil dalam hal pengukuran jarak tetapi memiliki error rate yang tinggi di setiap object. . Kemudian pada pengujian delay didapatkan perbedaan nilai yang sedikit pada object yang berbeda dan pada jarak tertentu dari satu hingga tiga meter didalam tiga kondisi.
Determination of efficacy of the cellular cardiomyoplasty, using navigation system NOGA XP
Authors: Estrin S. І. , Kravchenko T. V. , Pechenenko A. R. 
Published: March 2021

Objective. Improvement of the treatment results in patients with refractory angina, complicated by the heart insufficiency, using new methods of correction of the heart pumping function elaborated.
Materials and methods. Clinical investigation was performed, basing on retro- and prospective analysis of the treatment results in 156 patients: efficacy of myocardial remodeling was studied, using mesenchymal stem cells in patients, suffering refractory angina. For determination of the cellular therapy efficacy a navigation system NOGA XP was applied.
Results. There were presented the results of investigation of efficacy of intravenous injections of autologous mesenchymal stem cells to patients, suffering refractory angina, complicated by lowering of the heart pumping function, and immediate results of cardiomyoplasty using stem cells as well. For the first time a navigation system NOGA XP for determination of myocardial hibernation zones was applied in patients, suffering refractory angina. Also, using navigation system NOGA XP, the results of cellular cardiomyoplasty were obtained, while comparing electro-mechanical schemes before and after cellular therapy.
Conclusion. There was established the improvement of indices of the heart pumping function and the patients’ quality of life.