bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of severe acute pancreatitis with infected necrosis and concomitant Coronavirus Disease‑19 (COVID‑19): a nosocomial infection or delayed respiratory manifestation of viral disease?
Authors: Susak Y. , Tkachenko O. , Lobanova O. , Skivka L. 
Published: December 2021

The association between COVID‑19 and acute pancreatitis (AP) has been extensively analyzed in recent research and review papers worldwide. It should be noted that most studies have focused on AP as a COVID‑19 complication and/or an extra‑pulmonary manifestation of the disease, although the investigation reports on the cases of prior pancreatitis and subsequent COVID‑19 infection are limited.
The aim of this case report is to describe the treatment protocol and clinical outcome of a patient with acute necrotizing pancreatitis who developed nosocomial COVID‑19..
Case presentation. The data were collected from patient S., a 42‑year‑old male admitted with AP to the intensive care unit of Kyiv City Clinical Emergency Hospital, in October 2020. This study was reviewed and approved by the local Ethics Committee (Protocol No 25‑15‑60). The patient signed written informed consent to participate in the study, after having been informed of all relevant aspects that could influence his decision.
The patient, primarily diagnosed with AP, was admitted to the hospital without a PCR test for detecting SARS‑CoV‑2. 21 days after his admission to the hospital, the patient developed COVID‑19. AP progression to severe AP with infected necrosis, the development of systemic inflammatory response syndrome and multiple organ failure necessitated operative pancreatic debridement, which was postponed due to severe acute respiratory failure. Operative pancreatic debridement was performed on the 45th day of hospital stay after the resolution of COVID‑19‑associated pneumonia. The postoperative period was typical for the disease severity and the extent of the surgery, and was complicated by external pancreatic and colonic fistulas. The length of hospital stay for this patient was 115 days which included 20 days of treatment and monitoring in the intensive care unit due to pneumonia. He was discharged after clinical symptom improvement.
Conclusions. It is imperative to screen patients presenting with AP for SARS‑CoV‑2 in order to avoid misdiagnosis and inappropriate treatment strategy. Further detailed investigation of mechanisms of pancreatic injury in patients with SARS‑CoV‑2 is necessary.
Электрические токи в униполярных областях с разной скоростью затухания магнитного потока в пятне
Authors: Фурсяк Юрий , Плотников Андрей , Абраменко Валентина 
Published: December 2021

Используя магнитографические данные прибора Helioseismic and Magnetic Imager (HMI) на борту космического аппарата Solar Dynamics Observatory (SDO), мы вычислили параметры магнитного поля и электрических токов для униполярных активных областей (АО) с низкой (≤ 2.1 × 1019 Мкс ч−1, всего исследовано 11 АО) и высокой (≥ 7.0 × 1019 Мкс ч−1, проанализиро-вано 5 АО) скоростью затухания магнитного потока в пятне. Получены следующие результаты: 1) чем сильнее локальные (мелкомасштабные) электрические токи в окрестности униполярного пятна, тем быстрее оно затухает; 2) распределенный (глобальный, крупномасштабный) электрический ток вокруг быстро затухающих пятен практически нулевой, и от него не приходится ожидать стабилизирующего воздействия на процесс распада пятна; 3) для четырех случаев медленно затухающих пятен выявлен ненулевой распределенный электрический ток величиной до 5.0 × 1012 А. Такой ток может оказывать стабилизирующее действие на распад пятна.
Таким образом, полученные нами результаты указывают на то, что электрические токи малых масштабов оказывают скорее деструктивное воздействие на пятно, а присутствие крупномасштабных токов может стабилизировать пятно. Однако данный механизм, по-видимому, не является единственным и доминирующим в процессах стабилизации пятен.
Evaluación del valor protector de los trabajos de defensa del núcleo Canfranc-Estación
Authors: Esteban-Muñoz Alvaro , García-Robredo Fernando , Robredo Jose Carlos 
Published: December 2021

El cálculo del valor protector de obras de defensa como externalidad positiva resulta clave en aspectos como la ratificación económica o la toma de decisiones de conservación de las obras. Las obras de protección hidrológico-forestales situadas en Canfranc-Estación suponen un claro ejemplo de éxito que supera los 100 años de historia, pero que carece de validación económica y que se encuentra en paulatino deterioro. Con el objetivo de dar argumentos para mantener estas obras de protección se ha calculado su valor protector actual. Además, se han obtenido datos relevantes relativos al riesgo presente en Canfranc-Estación, afectado históricamente por inundaciones, por aludes y por caída de bloques.
Se han integrado y adaptado diferentes herramientas de valoración económica con base en el Método de los Costes Evitados. Para aplicar esta metodología se ha calculado el riesgo cuantitativo (RC) de los dos peligros principales– aludes e inundaciones -, descartando un tercer peligro – desprendimiento de bloques – por insuficiente relevancia. Ambos peligros se han modelado en dos escenarios: actual (S1) y sin obras (S2), en los cuales se han calculado los costes del proyecto (en S1) y el daño generado por cada peligro (en S1 y en S2). Los indicadores económicos e indicadores del riesgo verifican la alta rentabilidad y el alto valor protector de estas obras. Además, se han estimado los indicadores económicos de un hipotético proyecto consistente en realizar la misma obra en la actualidad, revelando la ventaja que pueden presentan este tipo de obras a largo plazo.
Palabras clave: Valor Actual Neto, IBER, RAMMS::AVALANCHE, Mantenimiento, Cuencas vertientes de montaña, Los Arañones.
Study of Elders’ Health Status and Perception about Old Age
Authors: Timalsina Keshab Prasad 
Published: December 2021

The health status of elders and elders’ perception regarding old age in a community is an important issue in a society. The present study aims to assess the health status and perception of old age of elderly population of Nijgadh Municipality. A descriptive cross-sectional study has been carried out among 204 elders taken from the community through simple random sampling method. The data were collected through face to face structured interview schedule in 2021. The descriptive and inferential statistical analysis of the collected data showed that the about 20 percent elders had got good status of health but remaining (about 80%) of them were suffering from some kinds of health complications. Similarly, more than 73 percent of elders felt their life more problematic. This study measured significant variation (p<0.05) of level of health status with only three socio-demographic variables (age, caste, and feeling of helplessness among the variables (gender, age groups, caste, living with or without spouse, literacy status, and feeling helplessness. Furthermore, this study measured significant variation (p<0.05) of perception about old age of elderly population with only three socio-demographic variable (age, caste, and feeling of helpless) among the variables (gender, age groups, caste, living with or without spouse, literacy status, and feeling helplessness). Based on the study, it can be said that age, caste, and feeling of helplessness status of elderly population were the major factors for creating variations in health status and perceptions of elderly life. The policies, programs, and community effort are needed for managing regular health service practice. Similarly, all the community members must be serious for keeping elders happy by managing their requirement with love which may require collective action from social, health and justice sectors.
EDUCOLOGICAL ASPECTS OF ACTUALITING OF REGULATORY DOCUMENTATION IN MECHANICAL ENGINEERING
Authors: Samokhval V. , Maksimenko О. , Nikulin О. 
Published: December 2021

The main competencies of specialists in the field of knowledge 13 Mechanical engineering appertain the ability to draw up technical documentation, which includes both the design of text documents and drawings of parts, units, assemblies. Over the last decade, there has been a significant update of the standards of both the Unified System of Design Documentation and the Unified System of Technological Documentation. Suitable, according to the principle of education, to ensure the quality of the educational process, the task of implementations modern regulations into the educational process and providing students with practical skills in the design of educational documentation, which is as approximate as possible to the technical future practice.
The purpose of the work is to develop proposals for the implementations of relevant regulations in the regulatory and methodological documentation of the educational process to ensure that higher education students acquire practical skills in applying this knowledge in the design of educational documentation with the closest possible approximation to real technical documentation.
From the analysis of the requirements of the acting standards that make up the system of design and technological documentation, it follows that their requirements are quite diverse and allow some flexibility of choice, depending on the needs of developers or consumers. Corresponding, according to the provisions of education, the current methodological and regulatory documentation of higher education institutions should provide information to students about the existing system of standards for technical documentation and their practical skills in applying such knowledge.
Based on the standards of the Unified System of Technological Documentation and DSTU EN ISO 7200: 2005, proposals have been developed for the design of educational documentation by students of mechanical engineering specialties according to educational and professional programs. The proposals concern the determine of the institution of higher education as the owner of the document, the numbering of documents of the educational process, the designation of sections of the document, page numbering, design of the main inscription of drawings and the title page of text documents.
In particular, a numbering system has been developed, which allows to mark the whole set of documents of the educational process of a particular applicant, individual documents by type, separate sections of text documents and drawings. A single form of the main inscription has been developed, which can be used both for text documents and for drawings.
The proposed innovations relate mainly to the specialties of mechanical engineering for educational and professional programs. But they can be used, in whole or in part, for other specialties and fields of knowledge.
MODIFICATION OF HEAT-RESISTANT OXIDES AND CHLORIDES OF GRAIN SURFACES OF SYNTHETIC DIAMOND GRINDING POWDERS FOR APPLICATION IN GRINDING TOOLS
Authors: Lavrinenko V. , Poltoratskyi V. , Pasichnyi О. , Solod V. , Muzichka D. 
Published: December 2021

Further development of modern technologies of diamond processing is connected with application in the diamond tool of powders with new unique properties, special morphology of grains, with the increased chemical and thermal stability. To increase the heat resistance of diamonds, they are covered with a metal (metallization) or glass-ceramic layer, or introduced into the reaction mixture used in the synthesis of diamonds, alloying additives of certain elements. Recently, other methods of coating to increase the heat resistance of diamonds have been developed, such as: vacuum ion-plasma sputtering, epitaxial synthesis, magnetron sputtering, the method of liquid-phase deposition. The latter method is promising for modifying the grain surface of grinding powders of superhard materials by heat-resistant inorganic non-metallic coatings, as it is the most economically advantageous.
Determining the features of the technology of modification by the method of liquid-phase application of heat-resistant inorganic coatings (oxides and chlorides of metals and nonmetals) on the surface of grains of grinding powders of synthetic diamond brand AC6, used for grinding tools in mechanical engineering.
Modification was performed by the isothermal method of liquid-phase application of saturated solutions of both heat-resistant oxides (В2О3, Al2O3), chlorides (СаСl2, NaCl, MgCl2, FeCl3), and their mixtures (В2О3+СаСl2, В2О3+NaCl). Based on the analysis of the results of the research, it can be stated that the application of coatings of inorganic substances (some oxides and chlorides) increases the heat resistance of synthetic diamond grinding powders. Modification allows to reduce expenses of diamonds in wheels at grinding.
Conditions for modification of heat-resistant oxides and chlorides, as well as their mixtures, grain surface of synthetic diamond grinding powders are determined. Modification of the surface of diamond grains with a combination of B2O3+Al2O3 is guaranteed to double the wear resistance of diamond wheels. It is established that in all cases of modification the roughness of the parameter Ra decreases. It is determined that by changing the surface modifier of diamond grains it is possible to affect the bearing capacity of the rough surface obtained by grinding.
The development of effective ways to increase the heat resistance of grinding powders made of superhard materials, primarily abrasive grinding powders made of synthetic diamond powders, helps to improve the quality of the grinding tool.
An Overview of Some Plant Based Products With Hepatoprotective Activity
Authors: Labhade Sonali Dnyaneshwar , Sharma Swapnil , Paliwal Sarvesh , Desai Shivani 
Published: December 2021

In folk medicine there are various medicinal amalgamation possessing hepatoprotective activity. This activity is of significance because several toxins cause liver injury. Hence, many pharmaceutical companies are targeting herbal medicines for the treatment of liver abnormalities and towards evolving a safe and effective formulation with desired route of administration. In current review we have focused on the studies showing hepatoprotective effect using marine compounds and plant derived compounds. Liver disorder, a global health problem, usually include acute or chronic hepatitis, heptoses, and cirrhosis. It may be due to toxic chemicals and certain antibiotics. Uncontrolled consumption of alcohol also affects liver in an unhealthy way. To cure liver disorders several formulations of medicinal plants are being used. It is observed that hepatoprotective effect of plant is mostly due to flavonoids, alkaloids, terpenoids, steroids, and glycoside. A single drug cannot be useful for all the types of liver disorders. Several plant extracts for liver illness results from poisonous chemicals, viruses, extra alcohol consumption, and repeated administration of medication. By using standards of protection and efficacy, manufacture of plant products need to be ruled out. Current review provides an understanding of ethnopharmocology, toxicology of several medicinal plants manifesting hepatoprotective potential. Despite of varied database analysis new discoveries and their probabilities, evidences on viral hepatitis treatment or liver cirrhosis is inadequate. Further information about phytotherapy, toxicology, quality control studies shall be endorsed. Further in depth studies are required to discover quality trait like SAR, MOA, safety and toxicity and therapeutic potential of phytoconstituents in clinical settings.
Formulation and Characterization of Nimodipine Nanoparticles for the Enhancement of solubility and dissolution rate
Authors: Alhagiesa Areej Wahhab , M. Ghareeb Mowafaq 
Published: December 2021

Nimodipine (NMD) is a dihydropyridine calcium channel blocker useful for the prevention and treatment of delayed ischemic effects. It belongs to class ? drugs, which is characterized by low solubility and high permeability. This research aimed to prepare Nimodipine nanoparticles (NMD NPs) for the enhancement of solubility and dissolution rate. The formulation of nanoparticles was done by the solvent anti-solvent technique using either magnetic stirrer or bath sonicator for maintaining the motion of the antisolvent phase. Five different stabilizers were used to prepare NMD NPs( TPGS, Soluplus®, HPMC E5, PVP K90, and poloxamer 407). The selected formula F2, in which Soluplus
has been utilized as a stabilizer, has a particle size (77 nm) and polydispersity index (PDI) (0.016). The formulas with the smallest particle size were freeze dried with the addition of 1 % w/w mannitol as cryoprotectant. The saturation solubility of NMD in the prepared nanoparticles was increased twenty four-folds, and the complete dissolution was achieved at 90 minutes compared with pure NMD, which reaches only 6%. The formation of hydrogen bonding between NMD and the polymer or the cryoprotectant, as confirmed by the FTIR study. In conclusion, the preparation of NMD as polymeric nanoparticles is a useful technique for enhancing the solubility and dissolution rate.
MEDICINAL PROPERTIES, RESOURCES AND PROTECTION OF CAPPARIS SPINOSA L. (CAPPARACEAE) IN THE NORTHWESTERN ADYRS OF THE FERGANA VALLEY
Authors: Imomov O. , Mirzaev S. , Shomatova U. , Ergasheva K. 
Published: December 2021

This work is devoted to the study of the medicinal properties of Capparis spinosa L. on the basis of the literatures and the assessment of natural resources in the Chust adyrs of the Namangan region of the Republic of Uzbekistan, as well as the protection measures. The medicinal properties of this plant are high, and it is widely used in folk and modern medicine, and the plant also contains a high concentration of nectar and is of great importance for beekeeping. In Europe it is used in the food industry and in cooking as a dietary product.
Plants are one of the most demanded medicinal raw materials, the demand is growing, but the available natural resources cannot meet this demand. Expansion of the plantation of Capparis spinosa and with rational use we will be able to conserve the natural resources of the plant.
TEACHING STUDENTS IN MODERN CONDITIONS
Authors: Ivanova M. 
Published: December 2021

The rapid forced transition to distance learning in the spring of 2020 served as an impetus for the development and introduction of new forms of education. Such a massive introduction of distance learning quickly revealed the advantages of traditional full-time education.
The first meetings with students after the experimentally remote semester showed a noticeable loss of students of some of the learning skills, for example necessary for working in a team. In addition, it is impossible to teach many technical disciplines qualitatively to a student without his presence in the classroom.
In the course of individual remote work with students (which entailed increased time costs), it became clear to teachers which points in the course should be paid more attention to, what to change in the presentation of educational material.
Thanks to technological progress, new ways of conducting classes have appeared in a remote form. Such classes can complement traditional full-time education
Inquiry-Based	Learning	Practices	for	Science	Teaching	in	Elementary	Grades:
A	Literature	Review	of	the	Asian	Countries
Authors: Ahmed Dool Mahmood , Akhtar Naeem , Khan Najmunnisa 
Published: December 2021

Inquiry-based	learning	(IBL)	is	a	student-centered	approach	of	instruction	that aims	at	increasing
students' active	engagement	and	their	skills	of	investigation,	reflection, and	critical	thinking	within	real-world
expressions	and	practices.	This	literature	review	includes	mostly	those	research	studies	in	which	a	quasiexperimental	approach	was	used, followed	by	a	pretest-posttest	design	with	random	allocation	of	research
participants.	As	per	the	aim	of	this	literature	review,	those	research	studies	were	included	where	elementary	grade
students	were	selected	as	research	participants	to	investigate	the	effects	of	IBL	approaches	on	students'	science
literacy	and skills.	One	of	the	engaging	lessons	from	this	review	shows	that	IBL	approach	science	skills	are	described
as	two	sides	of	the	same	coin.	Additionally,	almost	all	reviewed	studies	defined	IBL	as	students	centered	approach.
Moreover,	the	effects	of	IBL	are	also	discussed	in	detail
Effect of the Stress State on the Adhesive Strength of an Epoxy-Bonded Assembly
Authors: Smirnov Sergey , Konovalov Dmitry , Veretennikova Irina , Pestov Aleksander , Osipova Viktoria 
Published: December 2021

The paper studies the adhesive strength of aluminum alloy specimens bonded with the use of an epoxy adhesive, under the tensile-shear stress state, depending on the testing temperature. Tension of modified Arcan specimens with load angles of 0, 22.5, 45, 67.5, and 90° with respect to the plane of adhesion is chosen as the experimental method. Experiments were performed at temperatures of −50, +23, and +50 °С. The analysis of the obtained results yields a linear fracture criterion and a fracture locus for the adhesive failure strain energy density, which takes into account the ratio of the elastic properties of the adhesive to those of the substrate. The region bounded by the fracture loci of adhesive strength and ultimate strain energy density determines the conditions for the safe loading of the bonded assembly in terms of the energy and force criteria of adhesive failure. The proposed fracture loci can be used, preferably simultaneously, to estimate the in-service strength and reliability of adhesively bonded assemblies.
Methodical basis of formation of digital space performance of contractual construction works
Authors: Bondar O.A. , Yesipenko A.D. , Terentyev О.О. , Verenich O.V. , Petrenko H.S. 
Published: December 2021

The article searches for an appropriate methodology for the formation of methodological and formal analytical basis for the modernization of models of construction organization based on BIM models.
The leading area of application of BIM-technologies in construction is the transformation of disparate graphic and tabular elements from the design and estimate documentation into a single system of info-graphic graphic modules, which are integrated by a single information retrieval system. However, in the realities of the domestic construction market and construction administration systems, BIM technologies remain an aid to the visual-graphic and analytical presentation of the content of a construction development project as an object of construction and investment. However, the strategic trend of this market is the formation of construction development as a single environment of the construction project and as a format of construction administration. Given such strategic dominants, there is a need to redirect and readjust the functional content and graph-analytical design of VIM-technologies to the peculiarities of preparation and organization of the construction development project cycle (BDP) – from promoting the initial investment product idea to the end of the development contract. BIM-technologies should no longer be considered solely as an additional tool for visualizing the progress of the project cycle.
It is substantiated that the digital space of the construction industry (construction projects, construction organizations-participants) in the development of information and communication technologies acquires the characteristics of an alternative construction business, which should function in a certain transformed environment of construction development projects. Technologies directly related to design and construction (BIM, augmented reality, laser scanning, etc.) increase the efficiency of investment and construction projects, while digital data analysis systems contribute to a better understanding of construction market trends.