bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of knowledge extraction in predicting customer churn in B2B
Authors: Jamjoom Arwa A. 
Published: August 2021

AbstractData mining techniques were used to investigate the use of knowledge extraction in predicting customer churn in insurance companies. Data were included from a health insurance company for providing insight into churn behaviour based on a design and application of a prediction model. Additionally, three promising data mining techniques were identified for the prediction of modeling, including logistic regression, neural network, and K-means. The decision tree method was used in the modeling phase of CRISP-DM for identifying the attributes of churned customers. The predictive analysis task is undertaken through classification and regression techniques. K-means clustering variation is selected for exploring if the clustering algorithms categorize the customers in churning and non-churning groups with homogeneous profiles. The findings of the study show that data mining procedures can be very successful in extracting hidden information and get to know customer's information. The 50:50 training set distribution resulted in effective outcomes when the logistic regression technique was used throughout this study. A 70:30 distribution worked effectively for the neural network technique. In this regard, it is concluded that each technique works effectively with a different training set distribution. The predicted findings can have direct implications for the marketing department of the selected insurance company, whereas the models are anticipated to be readily applicable in other environments via this data mining approach. This study has shown that the prediction models can be utilized throughout a health insurance company's marketing strategy and in a general academic context with a combination of a research-based emphasis with a business problem-solving approach.
STEM doctoral students’ skill development: does funding mechanism matter?
Authors: Grote Dustin , Patrick Anita , Lyles Chelsea , Knight David , Borrego Maura , Alsharif Abdulrahman 
Published: August 2021

AbstractBackgroundA substantial monetary investment supports STEM doctoral students in the United States (U.S.) through a variety of funding mechanisms (e.g., fellowships, research, and teaching assistantships). However, we have limited knowledge of how students’ funding influences their development of career-relevant skills during graduate school. Using survey data from STEM doctoral students (n = 719) across 35 highly ranked U.S. institutions, we use exploratory factor analysis and nested multivariate regression modeling to understand how students’ primary funding influences development of: (a) research skills; (b) teamwork and project management skills; (c) peer training and mentoring skills, and (d) communication skills.ResultsWe find significant differences in students’ self-reported development for all four career-related skills based on their primary funding type. Students with research assistantships reported higher research and teamwork and project management skills than those with teaching assistantships. Yet, students with teaching assistantships reported significantly higher development of peer training and mentoring than students funded via all other types. Students funded via external fellowships reported lower skill development than students funded primarily by research assistantships across all four career-relevant skills.ConclusionsDoctoral students' development of career-relevant skills are not uniform across primary funding types. Particularly, the perceived benefits of external fellowship funding (i.e., prestige, autonomy, increased pay) may come at the cost of fewer opportunities to develop skills important for career success. STEM graduate education scholars, practitioners, and policymakers should consider and ameliorate the varied impacts that funding mechanisms can have on graduate students’ development of career-relevant skills.
Biocompatible natural deep eutectic solvent-based extraction and cellulolytic enzyme-mediated transformation of Pueraria mirifica isoflavones: a sustainable approach for increasing health-bioactive constituents
Authors: Makkliang Fonthip , Siriwarin Boondaree , Yusakul Gorawit , Phaisan Suppalak , Sakdamas Attapon , Chuphol Natthapon , Putalun Waraporn , Sakamoto Seiichi 
Published: August 2021

AbstractThe presence of specific gut microflora limits the biotransformation of Pueraria mirifica isoflavone (PMI) glycosides into absorbable aglycones, thus limiting their health benefits. Cellulolytic enzyme-assisted extraction (CAE) potentially solves this issue; however, solvent extraction requires recovery of the hydrophobic products. Here, we established the simultaneous transformation and extraction of PMIs using cellulolytic enzymes and natural deep eutectic solvents (NADESs). The NADES compositions were optimized to allow the use of NADESs as CAE media, and the extraction parameters were optimized using response surface methodology (RSM). The optimal conditions were 14.7% (v/v) choline chloride:propylene glycol (1:2 mol ratio, ChCl:PG) at 56.1 °C for the cellulolytic enzyme (262 mU/mL) reaction in which daidzin and genistin were extracted and wholly transformed to their aglycones daidzein and genistein. The extraction of PMIs using ChCl:PG is more efficient than that using conventional solvents; additionally, biocompatible ChCl:PG enhances cellulolytic enzyme activity, catalyzing the transformation of PMIs into compounds with higher estrogenicity and absorbability.
Near-channel classifier: symbiotic communication and classification in high-dimensional space
Authors: Hersche Michael , Lippuner Stefan , Korb Matthias , Benini Luca , Rahimi Abbas 
Published: August 2021

AbstractBrain-inspired high-dimensional (HD) computing represents and manipulates data using very long, random vectors with dimensionality in the thousands. This representation provides great robustness for various classification tasks where classifiers operate at low signal-to-noise ratio (SNR) conditions. Similarly, hyperdimensional modulation (HDM) leverages the robustness of complex-valued HD representations to reliably transmit information over a wireless channel, achieving a similar SNR gain compared to state-of-the-art codes. Here, we first propose methods to improve HDM in two ways: (1) reducing the complexity of encoding and decoding operations by generating, manipulating, and transmitting bipolar or integer vectors instead of complex vectors; (2) increasing the SNR gain by 0.2 dB using a new soft-feedback decoder; it can also increase the additive superposition capacity of HD vectors up to 1.7$$\times$$
×
in noise-free cases. Secondly, we propose to combine encoding/decoding aspects of communication with classification into a single framework by relying on multifaceted HD representations. This leads to a near-channel classification (NCC) approach that avoids transformations between different representations and the overhead of multiple layers of encoding/decoding, hence reducing latency and complexity of a wireless smart distributed system while providing robustness against noise and interference from other nodes. We provide a use-case for wearable hand gesture recognition with 5 classes from 64 EMG sensors, where the encoded vectors are transmitted to a remote node for either performing NCC, or reconstruction of the encoded data. In NCC mode, the original classification accuracy of 94% is maintained, even in the channel at SNR of 0 dB, by transmitting 10,000-bit vectors. We remove the redundancy by reducing the vector dimensionality to 2048-bit that still exhibits a graceful degradation: less than 6% accuracy loss is occurred in the channel at − 5 dB, and with the interference from 6 nodes that simultaneously transmit their encoded vectors. In the reconstruction mode, it improves the mean-squared error by up to 20 dB, compared to standard decoding, when transmitting 2048-dimensional vectors.
Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls
Authors: Golomb Beatrice Alexandra , Devaraj Sridevi , Messner Alexis K. , Koslik Hayley Jean , Han Jun Hee , Yik Barnabas 
Published: August 2021

Abstract
Background
Malondialdehyde (MDA) is a candidate general marker of oxidative stress (OS). We sought to assess the relation of MDA to Gulf War illness (GWI) and to a variety of exposures.

Methods
This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants (41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific model.

Results
Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate (OP) nerve gas was a strong predictor for lower MDA level in veterans with GWI.

Conclusion
Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.
Haematological reference intervals of sows at end gestation in ten French herds, the impact of parity on haematological parameters and the consequences on reproductive performance
Authors: Boulbria Gwenaël , Costa Charlotte Teixeira , Normand Valérie , Bachy Véronique , Rochel Daphné , Brissonnier Mathieu , Berton Pauline , Bouchet Franck , Lebret Arnaud 
Published: August 2021

AbstractBackgroundChanges in haematological values occur during the reproductive cycle. In veterinary swine practice, haematological reference intervals for this period are scarce. Over past decades, there has been a remarkable increase in reproductive prolificacy, possibly making previously established haematological reference intervals for sows outdated.ObjectivesThe aim of this study was to provide updated haematological reference intervals for sows at end-gestation, to study the influence of parity on those haematological parameters and to evaluate the impact of haemoglobin levels on production performance.MethodsThe data presented in this article were obtained using blood samples from 198 apparently healthy and conventionally managed group-housed sows at end-gestation from ten breeding herds located in France. The samples were analysed for haematological variables using impedance technique on Horiba ABX analyser (Horiba, Kyoto, Japan). The reference intervals were calculated according to the guidelines of The American Society for Veterinary Clinical Pathology using SUMMARY procedure in R Studio. Analysis of variance (ANOVA) models were used to evaluate the influence of parity on each haematological parameter and the impact of haemoglobin values on production performances at farrowing. Differences were considered as significant ifp < 0.05.ResultsReference intervals produced in this study were similar to previously published references but we noticed marked differences in white blood cell values. The study of the impact of parity revealed significant changes for gilts and parity 5 + sows regarding haematological values. Gilts had higher red and white blood cells counts, haemoglobin values and haematocrit values. Regarding haemoglobin values, the higher the number of liveborn and weaned piglets per litter, the lower the haemoglobin value at end-gestation. For sows of fifth or higher gestation, we found that the higher the percentage of stillborn piglets, the lower the haemoglobin value at end-gestation.ConclusionsThis study provides haematological reference intervals for sows at end-gestation. These will be useful for swine veterinarians and researchers for a better understanding of the influence of parity on haematological parameters and haemoglobin values and their relation to reproductive performance.
Eudiplozoon nipponicum: morphofunctional adaptations of diplozoid monogeneans for confronting their host
Authors: Valigurová Andrea , Vaškovicová Naděžda , Gelnar Milan , Kováčiková Magdaléna , Hodová Iveta 
Published: August 2021

Abstract
Background
Monogeneans, in general, show a range of unique adaptations to a parasitic lifestyle, making this group enormously diverse. Due to their unique biological properties, diplozoid monogeneans represent an attractive model group for various investigations on diverse biological interactions. However, despite numerous studies, there are still gaps in our knowledge of diplozoid biology and morphofunctional adaptations.

Results
In this study, we provide a comprehensive microscopic analysis of systems/structures involved in niche searching, sensing and self-protection against the host environment, and excretory/secretory processes in Eudiplozoon nipponicum. Freeze-etching enabled us to detect syncytium organisational features not visible by TEM alone, such as the presence of a membrane subjacent to the apical plasma membrane (separated by a dense protein layer) and a lack of basal plasma membrane. We located several types of secretory/excretory vesicles and bodies, including those attached to the superficial membranes of the tegument. Giant unicellular glands were seen accumulating predominantly in the apical forebody and hindbody haptor region. Muscle layer organisation differed from that generally described, with the outer circular and inner longitudinal muscles being basket-like interwoven by diagonal muscles with additional perpendicular muscles anchored to the tegument. Abundant muscles within the tegumentary ridges were detected, which presumably assist in fixing the parasite between the gill lamellae. Freeze-etching, alongside transmission electron and confocal microscopy with tubulin labelling, enabled visualisation of the protonephridia and nervous system, including the peripheral network and receptor innervation. Three types of receptor were identified: 1) uniciliated sensory endings with a subtle (or missing) tegumentary rim, 2) obviously raised uniciliated receptors with a prominent tegumentary rim (packed with massive innervation and muscles) and 3) non-ciliated papillae (restricted to the hindbody lateral region).

Conclusions
This study points to specific morphofunctional adaptations that have evolved in diplozoid monogeneans to confront their fish host. We clearly demonstrate that the combination of different microscopic techniques is beneficial and can reveal hidden differences, even in much-studied model organisms such as E. nipponicum.
The effect of option trading
Authors: Li Keming 
Published: August 2021

AbstractThis paper studies the effect of option trading on corporate investment and financing policies. Based on prior literature, I hypothesize that option market induces informed trading and thus reduces information asymmetry and the cost of capital. As a result, firms with high option trading have more investment and financing. Specifically, based on the United States public data, this paper finds that option trading volume increases corporate investment and financing, but reduces cash holdings and corporate payouts. These results are robust to the inclusion of industry or firm fixed effect, a control for endogenous options trading, and the use of alternative measures of option trading and corporate policies. The effect of option trading is stronger for firms with higher information asymmetry problems. Finally, this paper finds the results are inconsistent with the “quiet Life” hypothesis and the catering hypothesis.
Serum estrogen and its soluble receptor levels in Egyptian patients with acute leukemia: case-control study
Authors: El-Kaream Samir Ali Abd , Ebied Samia Abd El-Moneim , Sadek Nadia Ali , Saad Dina Mohamed , Nadwan Eman Attia 
Published: August 2021

Abstract
Background
Acute leukemias are malignant neoplastic diseases that arise from either lymphoid [ALL] or myeloid [AML] cell lines that are distinguished by the proliferation of BM non-functional immature cells and subsequently released into the bloodstream. ALL is prevalent malignancy in young, while AML in older. Diagnosis is usually routinely performed through peripheral blood count and smear then confirmed by BM aspirate. It is remarkable to notice that leukemia can be manifested at high, low, and even at normal leucocyte count. While treatment results have improved steadily over the last decades in younger and adults, limited changes have been in survival among subjects of age > 60 years. Aim of the work is to measure the serum estrogen [E2] and its soluble receptor [ER] levels in acute leukemia patients and extrapolate its possible clinical significance. This study included 40 [20 females and 20 males] healthy volunteers clinically free from any disease, 40 [20 females and 20 males] AML patients, and 40 [20 females and 20 males] ALL. To all subjects, serum E2 and its soluble ER level were investigated by ELISA.

Results
Serum E2 [pg/ml] level was lower in AML and ALL female and male patients groups than control group. Serum ER [ng/ml] level was lower in AML and ALL female and male patients groups than control group.

Conclusion
Estimation of serum E2 and its soluble ER level is of edifying diagnostic value. Determination of serum E2 and its soluble ER level in AML and ALL patients is of value in deciding treatment therapeutic target protocol.
FSH versus AMH: age-related relevance to ICSI results
Authors: Salama Sameh , Sharaf Marwa , Salem Sondos M. , Rasheed Mazen Abdel , Salama Ehab , Elnahas Tamer , Lotfy Rehab 
Published: August 2021

AbstractBackgroundWomen’s fecundity is known to decrease with the increase in chronologic age. Several biomarkers of the ovarian reserve, including follicle stimulating hormone (FSH), anti Müllerian hormone (AMH), have been proposed as possible predictors for the response to controlled ovarian stimulation (COS). Although there are assumptions indicating that the relationship between age and ovarian reserve is highly variable and the potential different validity of ovarian reserve markers in women in different age groups remains to be demonstrated. The purpose of our study was evaluating FSH and AMH as potential predictors of response to controlled ovarian stimulation and prediction of intracytoplasmic sperm injection (ICSI) outcome according to age. This prospective study has been carried out on 218 women having ICSI cycles. Cases were divided into two groups, group 1 (n148), their age < 35 years, and group 2 (n70), their age ≥ 35 years. All women received antagonist protocol during their ICSI cycles. Basal FSH and AMH were measured and correlated to the number of follicles on the day of trigger, the number of oocytes retrieved, chemical, and clinical pregnancies.ResultsThe fertilization rate in group 1 was 68.15%, while in group 2 was 77.82% (p = 0.003) while the implantation rate (number of gestational sacs observed at 6 weeks of pregnancy divided by the number of transferred embryos) was 18.95 and 11.98% in group 1 and group 2, respectively (p = 0.041). The clinical pregnancy rate among both groups was 38.51% in group 1, while 24.29% in group 2 (p = 0.038). Women who got pregnant among those aged < 35 years had significantly lower basal FSH (p < 0.001), while women who got pregnant among those aged ≥ 35 years had significantly higher AMH levels (pvalue < 0.001) and higher E2 levels on the day of trigger (p = 0.007).ConclusionWe found that below the age of 35 years, the chances of pregnancy are more correlated to FSH levels, while above the age of 35 years, AMH was a more relevant test.
Carotid blowout syndrome: endovascular management of a lesser known oncological emergency: case report
Authors: Singh Jitender , Sharma Tarika , Tripathy Taraprasad 
Published: August 2021

Abstract
Background
Carotid blowout syndrome (CBS) refers to a fatal hemorrhagic complication of cervical carotid arteries that occurs due to rupture of the extracranial carotid artery or one of its major branches in patients treated for head and neck malignancy. In this article, we will discuss two different spectrum of CBS and endovascular approach.

Case presentation
Two cases of per oral bleeding presented in the emergency department. After patients were hemodynamically stabilized, CT angiography was done which showed type II CBS and type III CBS, respectively. This was followed by transfemoral supra-aortic digital subtraction angiogram coil embolization with scaffolding and anchoring technique, respectively, for the patients.

Conclusions
Early recognition of the predictors of CBS by a multidisciplinary team is critical. The endovascular treatment approach is relatively safe and effective with low rates of morbidity and mortality compared to surgical approach in CBS.
GC–MS analysis, toxicological and oral glucose tolerance assessments of methanolic leaf extract of Eucalyptus globulus
Authors: Ajilore Bamidele Stephen , Oluwadairo Tolulope Olamide , Olorunnisola Olubukola Sinbad , Fadahunsi Olumide Samuel , Adegbola Peter Ifeoluwa 
Published: August 2021

Abstract
Background
Eucalyptus globulus leaf has shown promising potential in its efficacy to manage some diseases but little is known about its safety and its use in the management of diabetes. This study was designed to identify the bioactive compounds present in Eucalyptus globulus leaf extract (EGLEX), assess its toxic effects and its oral glucose tolerance ability. Powdered Eucalyptus globulus leaf was extracted with methanol using standard extraction procedure. Preliminary phytochemistry, gas chromatography–mass spectrometry (GCMS) analysis of the extract, its acute and subacute toxic effects and on its glucose tolerance (in-vivo) capability were assessed using standard laboratory techniques.

Results
EGLEX was tested positive for the presence of alkaloids, cardiac glycosides, flavonoids, tannins, phlobatannins and terpenoids. Nine compounds were identified by GCMS analysis of the leaf extract. EGLEX (up to 300 mg/kg bwt) showed no toxicity in all the rats dosed for the period of 14 days. The histomorphological study of the liver and kidney tissues harvested from rats dosed with 2000 mg/kg bwt showed features of histoarchitectural distortions in the two tissues. EGLEX (200 mg/kg bwt) further demonstrated effective glucose utilization as insulin and metformin.

Conclusions
The results obtained deduced that EGLEX is safe at a lower dose of 300 mg/kg bwt but toxic at higher dose of 2000 mg/kg bwt, and that single dose (200 mg/kg bwt) of the plant extract prevented hyperglycemia in normal rats.
Titin M-line insertion sequence 7 is required for proper cardiac function in mice
Authors: Biquand Ariane , Spinozzi Simone , Tonino Paola , Cosette Jérémie , Strom Joshua , Elbeck Zaher , Knöll Ralph , Granzier Henk , Lostal William , Richard Isabelle 
Published: August 2021

ABSTRACT
Titin is a giant sarcomeric protein that is involved in a large number of functions, with a primary role in skeletal and cardiac sarcomere organization and stiffness. The titin gene (TTN) is subject to various alternative splicing events, but in the region that is present at the M-line, the only exon that can be spliced out is Mex5, which encodes for the insertion sequence 7 (is7). Interestingly, in the heart, the majority of titin isoforms are Mex5+, suggesting a cardiac role for is7. Here, we performed comprehensive functional, histological, transcriptomic, microscopic and molecular analyses of a mouse model lacking the Ttn Mex5 exon (ΔMex5), and revealed that the absence of the is7 is causative for dilated cardiomyopathy. ΔMex5 mice showed altered cardiac function accompanied by increased fibrosis and ultrastructural alterations. Abnormal expression of excitation–contraction coupling proteins was also observed. The results reported here confirm the importance of the C-terminal region of titin in cardiac function and are the first to suggest a possible relationship between the is7 and excitation–contraction coupling. Finally, these findings give important insights for the identification of new targets in the treatment of titinopathies.