bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do the Successful Revision Surgery for Humeral Nonunion Solve all the Effects on Health-Related Quality of life? A Retrospective Cohort Study
Authors: Wang Zhimeng , Lu Yao , Sun Liang , Song Leilei , Ma Teng , Wang Qiang , Zhang Kun , Li Zhong 
Published: February 2021

Abstract
Background To evaluate the effects of successful revision operation on health quality of life(QoL) and functional outcome in humeral nonunion patients.Methods This retrospective study included 62 patients with humeral nonunion from Northwest China, who were admitted to the Department of Trauma Surgery, Honghui Hospital between March 2013 and September 2019. The following data were retrospectively evaluated: demographic data, clinical data, imaging findings, and treatment methods. The QoL assessment indicators for humeral nonunion patients included the SF-12 mental component summary(MCS) and physical component summary(PCS),brief pain inventory-severity(BPI-S) and brief pain inventory-interference (BPI-I). The mayo elbow performance score(MEPS) was used to assess the elbow function of the patients.Results Successful revision surgery significantly improved the patient's PCS,MCS,BPI-S and BPI-I scores (p<0.001). According to the MEPS criteria, the excellent and good rates were 95.16% in this study. The impact of humeral nonunion on mental health was comparable with the reported impact of stroke and type Ⅱ diabetes (p>0.05).The impact of post-op on physical health was comparable with the reported impact of COPD, silicosis, hypertension, barrentt’s esophagus and lower urinary tract symptoms(p>0.05).Conclusion Humeral nonunion is a devastating chronic medical condition that negatively affects both physical and mental health as well as quality of life. Although the effects of pain in the body can be completely relieved by treatment, the entire medical process may cause everlasting psychological trauma to the patient.
Tratamento farmacológico e não farmacológico da disfunção temporomandibular: uma revisão da literatura
Authors: Araújo Ozanna Soares Medeiros de , Cruz José Henrique de Araújo , Oliveira Filho Abrahão Alves de , Alves Maria Angélica Satyro Gomes 
Published: February 2021

Introdução: A disfunção temporomandibular tem sido reconhecida como uma das causas das dores orofaciais, nesta condição existe o envolvimento da articulação temporomandibular como também os músculos da mastigação. Esta disfunção têm sido identificado por alguns sintomas e sinais característicos como, pontos de gatilho musculares, comprometimento da dimensão vertical de oclusão, modificações na oclusão dental, luxação e a subluxação da mandíbula. Objetivo: Este trabalho objetiva a identificação e a análise dos tratamentos farmacológicos (anti-inflamatórios não esteroidais; anti-inflamatórios esteroidais; antidepressivos tricíclicos; relaxantes musculares e também os anestésicos locais) e não farmacológicos, estes incluídos no tratamento alternativos utilizados na disfunção temporomandibular (Acupuntura, Toxina botulínica, Estimulação nervosa elétrica transcutânea, e Técnicas de massoterapia. Material e métodos. Metodologia: Foram escolhidos 41 artigos presentes em plataformas cientificas, como o Periódico Capes, PubMed, Scielo e Google Acadêmico, no período de publicação entre 2006 e 2019. Conclusão: Por fim, nota-se que a disfunção temporomandibular é uma condição que acomete muito a população e que sua terapia pode ser realizada de diversas formas, desde com a terapia medicamentosa como também a realização de tratamentos alternativos.
Cancer risk assessment and modeling of groundwater contamination near industrial estate, Lahore, Pakistan
Authors: Jalees Muhammad Irfan , Farooq Muhammad Umar , Shah Asma Tufail 
Published: February 2021

Abstract
More than 60% of the population of Pakistan has no access to safe drinking water. Industrial zones near populated areas make conditions more severe due to continuous contamination. The aim of this study was to use statistical tools for correlation and source identification and health risk assessment of contamination due to Sundar Industrial Estate (SIE), Lahore, Pakistan. Drinking and wastewater samples were collected from SIE and analyzed for physical, chemical, microbial, and heavy metals analysis. Results showed that heavy metals and microbial contamination were beyond the National Drinking Water Quality Standards of Pakistan while high values of chemical oxygen demand (COD) and biochemical oxygen demand (BOD) wastewater were responsible for contamination of drinking water through seepage. There was a medium to strong correlation among parameters of all samples as indicated by Pearson correlation and analysis of variance. Principal component analysis and cluster analysis indicated sources of contamination, i.e., refuse leachate and untreated effluent discharges as main source of pollutants for drinking water. Health risk assessment showed a high intake of heavy metals through drinking water. Hazard quotient and hazard index indicated high probability of non-carcinogenic risk while cancer risk assessment suggested that out of every 100 of the population 93 people may suffer carcinogenic effects.
Integrated constructed wetlands treating industrial wastewater from seed production
Authors: Kiflay Elizabeth , Selemani Juma , Njau Karoli 
Published: February 2021

Abstract
The performance of an integrated wastewater treatment system composed of a horizontal subsurface flow constructed wetland (HSSFCW), floating constructed wetland (FCW), and anaerobic baffled reactor (ABR) was studied for pollutant removal from seed production wastewater. Cyperus alternifolius (Umbrella Papyrus) plants were used in the HSSFCW, and Vetiveria zizanioides (Vetiver grass) in the FCW. The ABR was fed with 25 /d wastewater from its equalization tank. The average raw wastewater organic loading rate was 0.208 kg-COD/d. Grab wastewater samples were collected twice weekly for three months from each unit's inlet and outlet. The system's performance in removing biochemical oxygen demand (), chemical oxygen demand (COD), total suspended solids (TSS), turbidity, nitrate, phosphate, and ammonium was studied. The average removal efficiencies obtained were 95.5% , 94.6% COD, 86.2% TSS, 76.6% turbidity, 82.4% nitrate, 76% phosphate, and 32.9% ammonium. The results show that integrating ABR, HSSFCW, and FCW improves pollutant removal from seed production wastewater, and the treated water can be used for agricultural purposes.
A neural network-based prediction model in water monitoring networks
Authors: Ji Xiaohong , Pan Ying , Jia Guoqing , Fang Weidong 
Published: February 2021

Abstract
To improve the prediction accuracy of ammonia nitrogen in water monitoring networks, the combination of a bio-inspired algorithm and back propagation neural network (BPNN) has often been deployed. However, due to the limitations of the bio-inspired algorithm, it would also fall into the local optimal. In this paper, the seagull optimization algorithm (SOA) was used to optimize the structure of BPNN to obtain a better prediction model. Then, an improved SOA (ISOA) was proposed, and the common functional validation method was used to verify its optimization performance. Finally, the ISOA was applied to improve BPNN, which is known as the improved seagull optimization algorithm–back propagation (ISOA–BP) model. The simulation results showed that the prediction accuracy of ammonia nitrogen was greatly improved and the proposed model can be better applied to the prediction of complex water quality parameters in water monitoring networks.
Nuclear Long Non-Coding RNAs as Epigenetic Regulators in Cancer
Authors: Tachiwana Hiroaki , Saitoh Noriko 
Published: February 2021

Background:
Transcriptome analyses have revealed the presence of numerous
long non-coding RNAs (lncRNAs) in mammalian cells. Many lncRNAs are expressed in
development-, differentiation-, and disease-specific manners, suggesting their importance
as cell regulators. Some nuclear lncRNAs are bound to specific genomic loci, either near
or distant from their own transcription sites, and regulate gene expression in cis or trans.
These lncRNAs recruit epigenetic factors, including the DNA methyl transferase and histone
modification complex, and mediate both the 3D genome structure and nuclear domains.
LncRNAs are now considered as an emerging member of epigenetic regulators.
LncRNAs are dysregulated in various types of cancer and act as either oncogenic or tumor-
suppressing factors. They are involved in virtually all of the cancer hallmarks and
are potential diagnostic markers and therapeutic targets.

Objective:
In this review, we describe several representative lncRNAs and provide a current
overview of the mechanisms by which lncRNAs participate in epigenetic regulation
and contribute to cancer development.
Visual and Quantitative Assessment of COVID-19 Pneumonia on Chest CT: The Relationship with Disease Severity and Clinical Findings
Authors: Kaya Furkan , Konya Petek Şarlak , Demirel Emin , Demirtürk Neşe , Orhan Semiha , Ufuk Furkan 
Published: February 2021

Background:
Lungs are the primary organ involved in COVID-19, and the severity of
pneumonia in COVID-19 patients is an important cause of morbidity and mortality.

Aim:
We aimed to evaluate the pneumonia severity through the visual and quantitative assessment
on chest computed tomography (CT) in patients with coronavirus disease 2019 (COVID-19) and
compare the CT findings with clinical and laboratory findings.

Methods:
We retrospectively evaluated adult COVID-19 patients who underwent chest CT along
with theirclinical scores, laboratory findings, and length of hospital stay. Two independent radiologists
visually evaluated the pneumonia severity on chest CT (VSQS). Quantitative CT (QCT) assessment
was performed using a free DICOM viewer, and the percentage of the well-aerated lung
(%WAL), high-attenuation areas (%HAA) at different threshold values, and mean lung attenuation
(MLA) values were calculated. The relationship between CT scores and the clinical, laboratory data,
and the length of hospital stay were evaluated in this cross-sectional study. The student's t-test
and chi-square test were used to analyze the differences between the variables. The Pearson correlation
test analyzed the correlation between the variables. The diagnostic performance of the variables
was assessed using the receiver operating characteristic (ROC) analysis.

Results:
The VSQS and QCT scores were significantly correlated with procalcitonin, d-dimer, ferritin,
and C-reactive protein levels. Both VSQ and QCT scores were significantly correlated with
the disease severity (p < 0.001). Among the QCT parameters, the %HAA-600 value showed the
best correlation with the VSQS (r = 730, p < 0.001). VSQS and QCT scores had high sensitivity
and specificity in distinguishing disease severity and predicting prolonged hospitalization.

Conclusion:
The VSQS and QCT scores can help manage the COVID-19 and predict the duration
of the hospitalization.
COVID-19: Challenges and its Technological Solutions using IoT
Authors: Ajaz Farhana , Naseem Mohd , Sharma Sparsh , Shabaz Mohammad , Dhiman Gaurav 
Published: February 2021

Abstract:
COVID-19 is a global pandemic that has affected many countries in a short span of
time. People worldwide are susceptible to this deadly disease. To control the prevailing havoc of
coronavirus, researchers are adopting techniques like plasma therapy, proning, medicines, etc. To
stop the rapid spread of COVID-19, contact tracing is one of the important ways to check the infected
people. This paper explains the various challenges people and health practitioners are facing due
to COVID-19. In this paper, various ways with which the impact of COVID-19 can be controlled
using IoT technology have been discussed. A six-layer architecture of IoT solutions for containing
the deadly COVID-19 has been proposed. In addition to this, the role of machine learning techniques
for diagnosing COVID-19 has been discussed in this paper, and a quick explanation of the
unmanned aerial vehicle (UAVs) applications for contact tracing has also been specified. From the
study conducted, it is evident that IoT solutions can be used in various ways for restricting the impact
of COVID-19. Furthermore, IoT can be used in the healthcare sector to assure people's safety
and good health with minimal costs.
Antioxidant Activity of Phenolic Compounds in Ethanolic Extract of Hibiscus sabdariffa L. on Oxidative Stability of Soybean Oil
Authors: Hiromoto Patricia Joho , Umeda Wellington Mamoro , Jorge Neuza 
Published: February 2021

Background:The current interest in natural antioxidants from vegetable sources, mainly in bioactive antioxidants, has been increasing in Brazil. The Hibiscus sabdariffa L. is rich in bioactive compounds, besides having antioxidant and antimicrobial properties.Objective:This study aimed to evaluate the antioxidant effect of hibiscus extract on the oxidative stability of soybean oil in an accelerated storage test.Methods:The ethanolic extracts of calyces and hibiscus seeds were evaluated for total phenolic compounds and antioxidant activity using DPPH, FRAP, and β-carotene/linoleic acid. The treatments identified as OS, Tocopherol, Extract, and Mixture, were prepared and submitted to accelerated storage at 60°C. The samples were analyzed on days 0, 6, and 12 for peroxides index, p-anisidine, total oxidation value, oxidative stability, and tocopherols.Results:The extract of calyces of hibiscus presented higher amounts of total phenolic compounds and antioxidant activity. Therefore, it was added to soybean oil. The Extract treatment promoted greater efficiency to inhibit the formation of primary and secondary compounds of lipid oxidation. It provided high oxidative stability to the soybean oil, in addition to greater retention of tocopherols, mainly α- and γ-tocopherol isomers.Conclusion:Among the treatments studied, Extract promoted greater efficiency in the inhibition of the formation of primary and secondary compounds of lipid oxidation, besides providing greater oxidative stability and greater retention of tocopherols during storage.
STABIL-study: The Course of Therapy, Safety and Pharmacokinetic Parameters of Conversion of Prograf® to Tacrolimus HEXAL®/Crilomus® in Renal Transplant Recipients – An Observational Study in Germany
Authors: Lehner Lukas J. , Kalb Klaus , Weigand Karl , Pein Ulrich , Schenker Peter , Seeger Wolfgang , Roehle Robert , Dienes Kerstin , Halleck Fabian , Budde Klemens 
Published: February 2021

Background/Objective:
Tacrolimus HEXAL®/Crilomus® is an approved generic immunosuppressant
for the prevention and treatment of rejection following renal transplantation. For
safe and socioeconomically efficient conversion of the innovator into a generic formulation, high-
-quality data are necessary, in view of the different and country-specific comorbidities and pharmacokinetics
in kidney transplant recipients.

Patients and Methods:
From 2014 to 2017, we enrolled 32 kidney transplant recipients, receiving
newly prescribed Tacrolimus HEXAL®/Crilomus® in 5 German centers. Efficacy and safety data
were collected over 6-8 months and retrospectively compared to the period prior to conversion.

Results:
The mean tacrolimus trough level was 4.91 ng/mL Standard Deviation (SD) (SD ±1.7) before
and 5.06 ng/mL (SD ±1.97) after conversion. Mean tacrolimus trough concentration-dose-ratio
(+/- SD) was 187.1 ng/mL/mg/kg/day (SD 99.2) for the reference and 205.1 ng/mL/mg/kg/day (SD
133) for the generic product, resulting in a non-significant difference of 18.0 ng/mL/mg/kg/day
(SD 71.8) (p=0.84, Wilcoxon V=180). Overall, dosing had to be changed in 4 (14.8%) patients.
Graft function remained stable and no rejections occurred.

Conclusion:
In conclusion, conversion to the generic tacrolimus formulation can be considered
safe and feasible in long-term kidney transplant recipients in Germany. As suggested by guidelines,
vigilant therapeutic drug monitoring is recommended to account for possible tacrolimus concentration
variability on the individual patient level.
Dental Pulp from Human Exfoliated Deciduous Teeth-derived Stromal Cells Demonstrated Neuronal Potential: In Vivo and In Vitro Studies
Authors: Hochuli Agner H.D. , Senegaglia Alexandra C. , Selenko Ana H. , Fracaro Letícia , Brofman Paulo R.S. 
Published: February 2021

Background:
Mesenchymal Stromal Cells (MSC) have the potential for self-renewal
and differentiation in different tissues, characteristics that encourage their use in regenerative
medicine. Dental tissue MSCs are easy to collect, have the same embryonic origin as neurons and
have neuronal markers that allow their use in treating neurodegenerative diseases. Human Exfoliated
Deciduous teeth (SHED)-derived stromal cells are considered immature and present positive expression
of pluripotency and neuronal markers. Studies have shown that after the induction of neuronal
differentiation in vitro, SHED increased the expression of neuronal markers, such as βIIItubulin,
nestin, GFAP, NeuN, and NFM, demonstrating the potential use of these cells in preclinical
studies. The results of this review reflect the consensus that in diseases such as spinal cord injury,
cerebral ischaemia, and Alzheimer’s and Parkinson’s disease, SHED could function in the suppression
of the inflammatory response, neuroprotection, and neuronal replacement.

Conclusion:
For these cells to be used in large-scale clinical trials, standardization of the isolation
techniques and theneuronal induction medium are necessary. The potential of SHED to induce neuronal
differentiation is evident, demonstrating that this resource is promising and shows great potential
for use in future preclinical and clinical trials of neurodegenerative diseases.
Assessment of Trabecular Bone During Dental Implant Planning using Cone-beam Computed Tomography with High-resolution Parameters
Authors: Bohner Lauren , Tortamano Pedro , Gremse Felix , Chilvarquer Israel , Kleinheinz Johannes , Hanisch Marcel 
Published: February 2021

Background:
Cone-Beam Computed Tomography (CBCT) with high-resolution parameters may provide an acceptable resolution for bone assessment.

Objectives:
The purpose of this study is to assess trabecular bone using two cone-beam computed tomography (CBCT) devices with high-resolution parameters in comparison to micro-computed tomography (µCT).

Methods:
Bone samples (n=8) were acquired from dry mandibles and scanned by two CBCT devices: 1) VV (Veraview R100, Morita; FOV 4x4, 75kV, 9mA, voxel size 0.125µm); and PR (Prexion 3D, Prexion; FOV 5x5, 90kV, 4mA, 37s, voxel size 108µm). Gold-standard images were acquired using µCT (SkyScan 1272; Bruker; 80kV, 125mA, voxel size 16µm). Morphometric parameters (BvTv- Bone Volume Fraction, BsBv- Trabecular specific surface, TbTh- Trabecular thickness and TbSp- Trabecular separation) were measured. Statistical analysis was performed within ANOVA, Spearman Correlation test and Bland-Altmann plots with a statistical significance level at p=0.05.

Results:
CBCT devices showed similar BvTv values in comparison to µCT. No statistical difference was found for BvTv parameters assessed by CBCT devices and µCT. BsBv values were underestimated by CBCT devices (p<0.01), whereas TbTh and TbSp values were overestimated by them (p<0.01). Positive correlations were found between VV and µCT measurements for BvTv (r2= 0.65, p=0.00), such as between PR and µCT measurements for TbSp (r2= 0.50, p=0.04). For BsBv measurements, PR was negatively correlated with µCT (r2= -0.643, p=0.01).

Conclusion:
The evaluated CBCT device was able to assess trabecular bone. However, bone parameters were under or overestimated in comparison to µCT.
Religious Fundamentalism between Traits and Values
Authors: Carlucci Leonardo , Geertz Armin W. , Picconi Laura , Balsamo Michela 
Published: February 2021

Introduction:
Religious fundamentalism is a complex religious phenomenon that involves cultural and social domains. Like values, it would potentially provide a description of how human beings should be. Nevertheless, extensive research has focused on the association between traits and fundamentalism, while the link with values has so far been neglected.

Methods:
We examined how traits and values might predict religious fundamentalism in a sample of 250 Italian Catholics (57.5% females).

Results:
Results partially confirmed the significant positive correlation between neuroticism and consciousness traits and religious fundamentalism, and highlighted the strong positive association with openness to change/conservative dimension value. In addition, when the overlap between traits and values was controlled for, hierarchical regression showed that values predicted fundamentalism better than traits.

Conclusion:
These findings could support the hypothesis that religious fundamentalism can be conceptualized as a motivational-goal attitude trait more than an enduring disposition.
Evaluation of a Blended Relapse Prevention Program for Anxiety and Depression in General Practice: Qualitative Study
Authors: Krijnen-de Bruin Esther , Geerlings Jasmijn A , Muntingh Anna DT , Scholten Willemijn D , Maarsingh Otto R , van Straten Annemieke , Batelaan Neeltje M , van Meijel Berno 
Published: February 2021

Background
Existing studies have yet to investigate the perspectives of patients and professionals concerning relapse prevention programs for patients with remitted anxiety or depressive disorders in primary care. User opinions should be considered when optimizing the use and implementation of interventions.

Objective
This study aimed to evaluate the GET READY relapse prevention programs for patients with remitted anxiety or depressive disorders in general practice.

Methods
Semistructured interviews (N=26) and focus group interviews (N=2) with patients and mental health professionals (MHPs) in the Netherlands were performed. Patients with remitted anxiety or depressive disorders and their MHPs who participated in the GET READY study were interviewed individually. Findings from the interviews were tested in focus group interviews with patients and MHPs. Data were analyzed using thematic analysis.

Results
Participants were positive about the program because it created awareness of relapse risks. Lack of motivation, lack of recognizability, lack of support from the MHP, and symptom severity (too low or too high) appeared to be limiting factors in the use of the program. MHPs play a crucial role in motivating and supporting patients in relapse prevention. The perspectives of patients and MHPs were largely in accordance, although they had different perspectives concerning responsibilities for taking initiative.

Conclusions
The implementation of the GET READY program was challenging. Guidance from MHPs should be offered for relapse prevention programs based on eHealth. Both MHPs and patients should align their expectations concerning responsibilities in advance to ensure optimal usage. Usage of blended relapse prevention programs may be further enhanced by diagnosis-specific programs and easily accessible support from MHPs.

International Registered Report Identifier (IRRID)
RR2-10.1186/s12888-019-2034-6