bluuebunny/crossref_metadata_2025_split huggingface dataset:
Talking inclusion into being: communication as a facilitator and obstructor of an inclusive work environment
Authors: Wolfgruber Daniel , Stürmer Lina , Einwiller Sabine 
Published: July 2021

PurposeThe purpose of this article is to examine the communicative factors that facilitate or hamper the development of an inclusive work environment with an emphasis on the communication about equality, diversity, and inclusion (EDI), while taking diversity characteristics of employees into account.Design/methodology/approachIn total, 84 persons employed in Austria and Germany, who feature various observable and non-observable diversity characteristics, were interviewed following a problem-centered approach.FindingsThe results indicate that employees with (observable) diversity characteristics, who tend to feel less included, observe more excluding and marginalizing communication and practices in their organizations. Moreover, formal interpersonal communication appears to be more important to develop a highly inclusive workplace than informal interpersonal communication and other forms of communication about EDI.Research limitations/implicationsThe sample was rather imbalanced and comprised only employees in Austria and Germany, which limits the study's explanatory power. However, the findings stress the significance of formal interpersonal communication as the cornerstone of an inclusive workplace, which should be followed up in future research.Practical implicationsIn terms of the development of an inclusive work environment the findings suggest that strategic (i.e. formal) organizational communication about EDI issues is key to increase the perception of inclusion.Originality/valueThis paper contributes to the literature by demonstrating the importance of interpersonal communication as a key factor that facilitates, but also hampers an inclusive work environment.
Innovation mediating relationship between TQM and performance: cases of industrial certified companies
Authors: Khalfallah Meriem , Ben Salem Anis , Zorgati Hajer , Lakhal Lassaad 
Published: July 2021

PurposeThe purpose of this research is to analyze the reciprocal relation between total quality management (TQM) and innovation (product innovation and process innovation) and their impact on operational and financial performance.Design/methodology/approachThe data were obtained from a survey of 205 manufacturing companies. Structural equation modeling (SEM) was performed to evaluate the research model.FindingsThe results reveal that there is a reciprocal relationship between TQM and innovation. Moreover, the findings indicate a significant positive effect of product innovation and process innovation on operational performance and insignificant direct impact of TQM on operational performance. However, this effect is significant when it is mediated through product innovation and process innovation.Research limitations/implicationsThis paper helps practitioners to understand how TQM practices support both product and process innovation and the role of the latter in promoting the implementation of TQM practices and ensuring operational performance.Originality/valueThis study presents an innovative approach since it is among the first research studies that provide empirical evidence to a reciprocal association between TQM and innovation. Additionally, this paper examines the dimensions studied in different aspects. It considered financial performance and operational performance, and with respect to innovation, this dimension was analyzed through two different perspectives, namely product innovation and process innovation. This study is also among the first and few research studies that have studied the mediating effect of innovation.
Pyricularia sp. jiangsuensis, a new cryptic rice panicle blast pathogen from rice fields in Jiangsu Province, China
Authors: Du Yan , Qi Zhongqiang , Liang Dong , Yu Junjie , Yu Mina , Zhang Rongsheng , Cao Huijuan , Yong Mingli , Pan Xiayan , Yin Xiaole , Qiao Junqing , Liu Youzhou , Chen Zhiyi , Song Tianqiao , Liu Wende , Zhang Zhengguang , Liu Yongfeng 
Published: July 2021

SummaryPyricularia oryzae is a multi‐host pathogen causing cereal disease, including the devastating rice blast. Panicle blast is a serious stage, leading to severe yield loss. Thirty‐one isolates (average 4.1%) were collected from the rice panicle lesions at nine locations covering Jiangsu province from 2010 to 2017. These isolates were characterized as Pyricularia sp. jiangsuensis distinct from known Pyricularia species. The representative strain 18‐2 can infect rice panicle, root and five kinds of grasses. Intriguingly, strain 18‐2 can co‐infect rice leaf with P. oryzae Guy11. The whole genome of P. sp. jiangsuensis 18‐2 was sequenced. Nine effectors were distributed in translocation or inversion region, which may link to the rapid evolution of effectors. Twenty‐one homologues of known blast‐effectors were identified in strain 18‐2, seven effectors including the homologues of SLP1, BAS2, BAS113, CDIP2/3, MoHEG16 and Avr‐Pi54, were upregulated in the sample of inoculated panicle with strain 18‐2 at 24 hpi compared with inoculation at 8 hpi. Our results provide evidences that P. sp. jiangsuensis represents an addition to the mycobiota of blast disease. This study advances our understanding of the pathogenicity of P. sp. jiangsuensis to hosts, which sheds new light on the adaptability in the co‐evolution of pathogen and host.
Beyond Causality: Additional Benefits of Randomized Controlled Trials for Improving Health Care Delivery
Authors: ALSAN MARCELLA , FINKELSTEIN AMY N. 
Published: July 2021

Policy Points
Policymakers at federal and state agencies, health systems, payers, and providers need rigorous evidence for strategies to improve health care delivery and population health. This is all the more urgent now, during the COVID‐19 pandemic and its aftermath, especially among low‐income communities and communities of color.
Randomized controlled trials (RCTs) are known for their ability to produce credible causal impact estimates, which is why they are used to evaluate the safety and efficacy of drugs and, increasingly, to evaluate health care delivery and policy. But RCTs provide other benefits, allowing policymakers and researchers to: 1) design studies to answer the question they want to answer, 2) test theory and mechanisms to help enrich understanding beyond the results of a single study, 3) examine potentially subtle, indirect effects of a program or policy, and 4) collaborate closely to generate policy‐relevant findings.
Illustrating each of these points with examples of recent RCTs in health care, we demonstrate how policymakers can utilize RCTs to solve pressing challenges.
Investigation of microbial contamination in a chicken slaughterhouse environment
Authors: Song Xiangyu , Wang Huhu , Xu Xinglian 
Published: July 2021

AbstractThe environment in poultry abattoirs is the primary potential source of bacterial contamination and cross‐contamination of broiler carcasses. In this context, we explored the influence of chilling water and contact surfaces on the microbial diversity of broiler carcasses in warm and cold seasons. High‐throughput sequencing was used to target the V3‐V4 region of the 16S rRNA gene. Proteobacteria was the main phylum detected in broiler carcasses and on contact surfaces, whereas Bacteroidetes and Firmicutes had high abundances of the prechilling water in both seasons. At the genus level, Psychrobacter and Acinetobacter were much more abundant on broiler carcasses in the warm season, while Flavobacterium and Psychrobacter dominated in the cold season. LEfSe analysis showed that the chilling tank was a key location where carcass contamination occurred. Therefore, the risk of carcass contamination can be reduced by improving sanitary conditions during processing, installing longer chilling tanks, or increasing the water exchange rate in chilling tanks. The results of this study may be useful for better slaughterhouse environmental hygiene management in different seasons.Practical ApplicationThis study will help poultry processing managers better understand the impact of different seasons on the environmental microbiota in the environment and their abundance in poultry processing plants, thus allowing them to adopt proper disinfection strategies for different seasons and environments, further improving the safety and shelf life of products.
Multiple myeloma with t(11;14)‐associated immature phenotype has lower CD38 expression and higher BCL2 dependence
Authors: Kitadate Akihiro , Terao Toshiki , Narita Kentaro , Ikeda Sho , Takahashi Yuto , Tsushima Takafumi , Miura Daisuke , Takeuchi Masami , Takahashi Naoto , Matsue Kosei 
Published: July 2021

AbstractCD38 expression on myeloma cells is a critical factor affecting the early response to the anti‐CD38 antibody daratumumab. However, factors affecting CD38 expression in untreated multiple myeloma are not fully elucidated. In this study, we found that CD38 expression was significantly lower in myeloma patients with the translocation t(11;14)‐associated immature plasma cell phenotype, and particularly in those expressing B–cell‐associated genes such as PAX5 and CD79A. CD138, a representative marker of plasmacytic differentiation, was also significantly lower in these patients, suggesting that CD38 expression may be associated with the differentiation and maturation stages of myeloma cells. Furthermore, the BCL2/BCL2L1 ratio, a response marker of the BCL2 inhibitor venetoclax, was significantly higher in patients with the immature phenotype expressing B–cell‐associated genes. The BCL2/BCL2L1 ratio and CD38 expression were significantly negatively correlated. We also confirmed that patients with translocation t(11;14) expressing B–cell‐associated genes were indeed less sensitive to daratumumab‐mediated direct cytotoxicity but highly sensitive to venetoclax treatment in ex vivo assays. Moreover, all‐trans‐retinoic acid, which enhances CD38 expression and induces cell differentiation in myeloma cells, reduced B‐cell marker expression and the BCL2/BCL2L1 ratio in myeloma cell lines, leading to reduced efficacy of venetoclax. Venetoclax specifically induces cell death in myeloma with t(11;14), although why patients with translocation t(11;14) show BCL2 dependence is unclear. These results suggest that BCL2 dependence, as well as CD38 expression, are deeply associated with the differentiation and maturation stages of myeloma cells. This study highlights the importance of examining t(11;14) and considering cell maturity in myeloma treatment strategies.
The impact of ageing and menopause in women with polycystic ovary syndrome
Authors: Helvaci Nafiye , Yildiz Bulent O. 
Published: July 2021

AbstractPolycystic ovary syndrome (PCOS) is a common hormonal, metabolic and reproductive disorder. Women with PCOS at reproductive age have increased risk and prevalence of prediabetes and diabetes and have multiple risk factors for cardiometabolic disease and other comorbidities such as obstructive sleep apnoea, endometrial cancer and mood disorders, which contribute to the overall health burden of the syndrome. However, little is known about the impact of PCOS on long‐term health in ageing women. In this review, we aimed to give an updated overview regarding the long‐term health outcomes of PCOS and their clinical implications in peri‐ and postmenopause. The PCOS phenotype ameliorates with ageing and limited available data suggest that there is no further deterioration in cardiometabolic profile in women with PCOS after menopause. Accordingly, the risk of cardiovascular disease in ageing women with PCOS seems to be no different from those without PCOS and lower than previously anticipated based on their risk during reproductive years. Regarding other comorbidities including sleep apnoea, mood disorders and endometrial cancer, it is difficult to determine the true risk in older women with PCOS due to the confounding factors and lack of long‐term cohort studies. Large, prospective studies on community‐based and well‐phenotyped PCOS cohorts with extended follow‐up into late menopause are needed to confirm these findings.
Comparison of the accuracy of implant placement using different drilling systems for static computer‐assisted implant surgery: A simulation‐based experimental study
Authors: Sittikornpaiboon Paknisa , Arunjaroensuk Sirida , Kaboosaya Boosana , Subbalekha Keskanya , Mattheos Nikos , Pimkhaokham Atiphan 
Published: July 2021

AbstractBackgroundDifferent designs of surgical drilling systems have been developed for the purpose of static Computer‐Assisted Implant Surgery (sCAIS), but there is at present little understanding of how design principles affect the accuracy of implant placement.PurposeThe aim of this in vitro study was to compare the accuracy of implant placement among five drilling systems of sCAIS in a controlled experimental setting.Materials and MethodsTwenty‐five 3D printed models with two edentulous bilateral premolar spaces were allocated to five different drilling systems: group A: sleeve‐in‐sleeve, group B: sleeve‐in‐sleeve with self‐locking, group C: mounted sleeve‐on‐drill, group D: integrated sleeve‐on‐drill with metal sleeve in the guide, group E: integrated sleeve‐on‐drill without metal sleeve. Models were scanned with CBCT and optical scanner. All implants were digitally planned and 10 implants placed with sCAIS in each group. Postoperative 3D deviation of placed vs planned position was measured by means of platform, apex and angular deviation. Data was analyzed using Kruskal‐Wallis test (P ≤ .05). Pairwise comparisons were tested with Dunn's test with adjusted P values.ResultsThe overall platform deviation ranged from 0.42 ± 0.12 mm (group B) to 1.18 ± 0.19 mm (group C). The overall apex deviation ranged from 0.76 ± 0.22 mm (group B) to 1.95 ± 0.48 mm (group D). The overall angular deviation ranged from 2.50 ± 0.89 degree (group B) to 5.30 ± 1.04 degree (group E). Group A and B showed significantly less angular deviation than groups D and E (P < .05). There was no statistically significant differences in all parameters between group A and B, as well as between group D and E (P > .05).ConclusionsSignificant differences were found with regards to accuracy among the five sCAIS systems tested, suggesting that the drilling protocol, the devices used and the design principles of the guides could influence the accuracy of implant placement.
Global change on the roof of the world: Vulnerability of Himalayan otter species to land use and climate alterations
Authors: Jamwal Pushpinder S. , Di Febbraro Mirko , Carranza Maria Laura , Savage Melissa , Loy Anna 
Published: July 2021

AbstractAimClimate Change Vulnerability Assessment (CCVA) prescribes the quantification of species vulnerability based on three components: sensitivity, adaptive capacity and exposure. Such assessments should be performed through combined approaches that integrate trait‐based elements (e.g., measures of species sensitivity such as niche width) with correlative tools quantifying exposure (magnitude of changes in climate within species habitat). Furthermore, as land use alterations may increase climate impacts on biodiversity, CCVAs should focus on both climate and land use change effects. Unfortunately, most of such assessments have so far focused exclusively on exposure to climate change.LocationHimalaya.MethodsWe evaluated the vulnerability of three otter species occurring in the Himalayan region, that is, Aonyx cinereus, Lutra lutra and Lutrogale perspicillata, to 2050 climate and land use change through the recently proposed Climate Niche Factor Analysis (CNFA) framework combined with Species Distribution Models.ResultsFuture climate and land use change will reduce (6%–15%) and shift (10%–18%) the geographical range of the three species in the Himalaya, with land use alterations exerting far more severe effects than climate change. Among vulnerability components, sensitivity played a greater role than exposure in determining the vulnerability of the otters. Specifically, the most specialist species, L. perspicillata, showed the highest vulnerability in comparison with the most generalist, L. lutra.Main conclusionsOur results underline how coupling climate and land use change components in CCVAs can generate diverging predictions of species vulnerability compared to approaches relying on climate change only. Moreover, intrinsic components, such as species sensitivity, proved significantly more important in determining vulnerability than extrinsic metrics such as habitat exposure.
The thermal ecology of burying beetles: temperature influences reproduction and daily activity in Nicrophorus marginatus
Authors: Keller Maranda L. , Howard Daniel R. , Hall Carrie L. 
Published: July 2021

1. Understanding how organisms respond to thermal stress can help predict long‐term population viability under projected climate change models. Behavioural plasticity can mediate the impact of thermal stress; however, some behavioural modifications in response to novel environments act maladaptively and could implicate population persistence.2. Burying beetles (Silphidae: Nicrophorus) have been found to modify traits related to individual fitness to be favourable in their perceived environments. To reproduce, breeding individuals of the nicrophorine genus work together to bury and prepare a suitable vertebrate carcass as food for their developing larvae.3. Here, we explore how sustained temperature treatments influence traits that closely tie to individual fitness in Nicrophorus marginatus. We measure carcass handling, reproductive output, and activity levels in controlled and elevated temperature treatments.4. At only 27.5 °C, we observed significantly reduced reproductive success rates, extended carcass handling time, and increased levels of activity when compared to the baseline temperature treatment of 26 °C. Additionally, at 26.5 °C, we document reduced brood size.5. These findings indicate that slight incremental increases in temperature could have profound effects on burying beetle fitness when experienced for extended periods.
The role of long noncoding RNA THAP9‐AS1 in the osteogenic differentiation of dental pulp stem cells via the miR‐652‐3p/VEGFA axis
Authors: Wang Jia , Liu Xueyu , Wang Yue , Xin Bingchang , Wang Wei 
Published: July 2021

AbstractDental pulp stem cells (DPSCs) are multipotent and may play crucial roles in dentin‐pulp regeneration. Recent studies have revealed that long noncoding RNAs (lncRNAs) are implicated in the osteogenic differentiation of DPSCs. However, the specific role and potential mechanisms of the lncRNA trihydroxyacetophenone domain containing nine antisense RNA 1 (THAP9‐AS1) during osteogenic differentiation of DPSCs remain unknown. In the present study, we determined that THAP9‐AS1 expression was upregulated during osteogenic differentiation of DPSCs. Moreover, we investigated the biological functions of THAP9‐AS1 during osteogenic differentiation of DPSCs by loss‐of‐function assays. THAP9‐AS1 knockdown inhibited osteogenic differentiation of DPSCs by decreasing alkaline phosphatase activity, alkaline phosphatase‐positive cell ratio, mineralizing matrix and mRNA, and protein levels of early osteogenic‐markers. We also found that THAP9‐AS1 interacted with miR‐652‐3p, whose downstream gene target is vascular endothelial growth factor A (VEGFA). In addition, rescue assays indicated that VEGFA rescued the effects of THAP9‐AS1 knockdown during osteogenic differentiation of DPSCs. In summary, we verified that knockdown of THAP9‐AS1 inhibits osteogenic differentiation of DPSCs via the miR‐652‐3p/VEGFA axis. Our findings may be helpful to extend research on the mechanisms underlying osteogenic differentiation of DPSCs.
Long‐term safety and efficacy of add‐on cannabidiol in patients with Lennox–Gastaut syndrome: Results of a long‐term open‐label extension trial
Authors: Patel Anup D. , Mazurkiewicz‐Bełdzińska Maria , Chin Richard F. , Gil‐Nagel Antonio , Gunning Boudewijn , Halford Jonathan J. , Mitchell Wendy , Scott Perry Michael , Thiele Elizabeth A. , Weinstock Arie , Dunayevich Eduardo , Checketts Daniel , Devinsky Orrin 
Published: July 2021

SummaryObjectiveLennox–Gastaut syndrome (LGS) is an epileptic encephalopathy that is often treatment resistant. Efficacy and safety of add‐on cannabidiol (CBD) to treat seizures associated with LGS was demonstrated in two randomized controlled trials (RCTs). Patients who completed the RCTs were invited to enroll in this long‐term open‐label extension (OLE) trial, GWPCARE5 (NCT02224573). We present the final analysis of safety and efficacy outcomes from GWPCARE5.MethodsPatients received plant‐derived highly purified CBD (Epidiolex in the United States; Epidyolex in the European Union; 100 mg/ml oral solution), titrated to a target maintenance dose of 20 mg/kg/day over 2 weeks. Based on response and tolerability, CBD could then be reduced or increased up to 30 mg/kg/day.ResultsOf 368 patients with LGS who completed the RCTs, 366 (99.5%) enrolled in this OLE. Median and mean treatment duration were 1090 and 826 days (range = 3–1421), respectively, with a mean modal dose of 24 mg/kg/day. Adverse events (AEs) occurred in 96% of patients, serious AEs in 42%, and AE‐related discontinuations in 12%. Common AEs were convulsion (39%), diarrhea (38%), pyrexia (34%), and somnolence (29%). Fifty‐five (15%) patients experienced liver transaminase elevations more than three times the upper limit of normal; 40 (73%) were taking concomitant valproic acid. Median percent reductions from baseline ranged 48%–71% for drop seizures and 48%–68% for total seizures through 156 weeks. Across all 12‐week visit windows, 87% or more of patients/caregivers reported improvement in the patient's overall condition on the Subject/Caregiver Global Impression of Change scale.SignificanceLong‐term add‐on CBD treatment had a similar safety profile as in the original RCTs. Sustained reductions in drop and total seizure frequency were observed for up to 156 weeks, demonstrating long‐term benefits of CBD treatment for patients with LGS.
It takes three to tango: An ethnography of triadic involvement of residents, families and nurses in long‐term dementia care
Authors: Koster Luzan , Nies Henk 
Published: July 2021

AbstractBackgroundResearchers often stress the necessity and challenge of integrating the positionings of residents, family members and nurses in order to realize each actor's involvement in long‐term dementia care. Yet most studies approach user and family involvement separately.AimTo explain how productive involvement in care provision is accomplished in triadic relationships between residents, family members and nurses.MethodsAn ethnographic study of identity work, conducted between 2014 and 2016 in a Dutch nursing home.FindingsWe identify four ideal‐typical identity positionings performed by nurses through daily activities. The findings reveal how their identity positionings were inseparable from those of the residents and family members as they formed triads. Congruent, or ‘matching’, identity positionings set the stage for productive involvement. Our systematic analysis of participants' identity work shows how—through embedded rights and responsibilities—their positionings inherently shaped and formed the triadic types and degrees of involvement observed within these relationships.Discussion and conclusionThis study both unravels and juxtaposes the interrelatedness of, and differences between, the concepts of user and family involvement. Accordingly, our findings display how residents, family members and nurses—while continuously entangled in triadic relationships—can use their identity positionings to accomplish a variety of involvement activities. To mirror and optimize the implementation of user and family involvement, we propose a rights‐based and relational framework based on our findings.Patient or public contributionConversations with and observations of residents; feedback session with the Clients' Council.