bluuebunny/crossref_metadata_2025_split huggingface dataset:
Greater Post-Surgical Pain Predicts Long-Term Depressed Affect in	Breast Cancer Patients
Authors: Fisher Hannah M. , Taub Chloe J. , Lechner Suzanne C. , Antoni Michael H. 
Published: June 2021

Abstract. Background: Depressed affect is observed during primary treatment for early-stage breast cancer and often persists into survivorship. Pain can influence the long-term emotions of women with breast cancer. Behavioral mechanisms explaining this relationship are less clear. Coping during primary treatment may play a role in the association between pain and depressed affect. Aims: Our observational study examined a longitudinal mediation model testing whether post-surgical pain intensity predicted depressed affect 5 years later via disengagement and/or engagement coping at the end of treatment. Method: Women ( N = 240) with stage 0–III breast cancer completed measures of pain, coping, and depressed affect 4–10 weeks post-surgery, and 12 months and 5 years later. Results: Structural modeling yielded measurement models of 12-month disengagement and engagement coping. Direct effects emerged between post-surgical pain intensity and 12-month disengagement (β = .37, p < .001) and engagement coping (β = .16, p < .05). Post-surgical pain intensity was also related to 5-year depressed affect (β = .25, p < .05). Disengagement and engagement coping were not associated with depressed affect at 5-year follow-up, and there was no evidence of mediation. Limitations: This is a secondary analysis of data from a trial conducted several years ago, and may not generalize due to a homogenous sample with attrition at long-term follow-up. Conclusions: Greater post-surgical pain intensity predicts more disengagement and engagement coping at the end of primary treatment, as well as depressed affect during survivorship. Managing post-surgical pain may influence the emotions of survivors of breast cancer up to 5 years later, possibly through coping or non-coping processes.
Relationships Between Mindfulness Facets and Mental and Physical	Health in Meditating and Nonmeditating University Students
Authors: Karing Constance , Oeltjen Lara , Beelmann Andreas 
Published: June 2021

Abstract. Background: Little is known about the relations of the mindfulness facets to mental and physical health among meditators and nonmeditators. Aim: The main purpose of the present study was to investigate the relationship between the mindfulness facets and mental as well as physical health of university students with and without meditation experience using attentional control, body awareness, nonattachment, and emotion regulation as mediators. Method: Data were collected from a sample of 508 university students (meditators: n = 195, nonmeditators n = 313). Path analysis models were used to examine the associations between the mindfulness facets, all candidate mediators and the outcome variables mental and physical health complaints. Additionally, a bootstrapping procedure was used to test the significance of the indirect effects. Results: Results showed that the associations between the mindfulness facets, the proposed mediators, and mental and physical health complaints were similar between students with and without meditation experience. Nonattachment and body awareness were the most important mediators. Limitations: Only self-report questionnaires were used in the study, and the majority of the sample was women and enrolled in health and social science studies. Conclusion: The results indicated that the investigation of mindfulness at the facet level is worthwhile. The study helps to clarify the associations between the mindfulness facets and mental as well as physical health among students with and without meditation experience. Further, mindfulness mediators should be examined in intervention studies.
Evaluation of Extreme Temperatures Over Australia in the Historical Simulations of CMIP5 and CMIP6 Models
Authors: Deng Xu , Perkins‐Kirkpatrick Sarah E. , Lewis Sophie C. , Ritchie Elizabeth A. 
Published: June 2021

AbstractHistorical simulations of models participating in the sixth phase of the Coupled Model Intercomparison Project (CMIP6) are evaluated over 10 Australian regions for their performance in simulating extreme temperatures, among which three models with initial‐condition large ensembles (LEs) are used to estimate the effects of internal variability. Based on two observational data sets, the Australian Water Availability Project (AWAP) and the Berkeley Earth Surface Temperatures (BEST), we first analyze the models' abilities in simulating the probability distributions of daily maximum and minimum temperature (TX and TN), followed by the spatial patterns and temporal variations of the extreme indices, as defined by the Expert Team on Climate Change Detection and Indices (ETCCDI). Overall, the CMIP6 models are comparable to CMIP5, with modest improvements shown in CMIP6. Compared to CMIP5, the CMIP6 ensemble tends to have narrower interquartile model ranges for some cold extremes, as well as narrower ensemble ranges in temporal trends for most indices. Over southeast, tropical, and southern regions, both CMIP ensembles generally exhibit relatively large deficiencies in simulating temperature extremes. We also confirm that internal variability can affect the trends of the extremes and there is uncertainty in representing the irreducible variability among different LEs in CMIP6. Furthermore, the evaluation based on Perkins' skill score (PSS) and root‐mean‐square error (RMSE) in the three LEs does not directly correlate with the ranges of the trends for extreme temperatures. The findings of this study are useful in informing and interpreting future projections of temperature‐related extremes over Australia.
Learning the Low Frequency Earthquake Activity on the Central San Andreas Fault
Authors: Johnson Christopher W. , Johnson Paul A. 
Published: June 2021

AbstractLow frequency earthquakes (LFEs) originating below the central San Andreas Fault are associated with slow‐slip beneath the seismogenic zone within the more ductile portion of the crust. Monitoring efforts over 15 years detected >1 million LFEs. We train a gradient boosted tree model using statistical features describing the seismic waveforms to estimate the hourly LFE event count. The burst‐like LFE behavior is reproduced, while lower amplitudes are predicted during the most active periods. The hourly event counts are up to 18% greater than the catalog. The ability to continuously monitor LFE activity provides insight to when geodetic measurements of slow slip are possible, without the need for developing a computational‐intensive template‐matching catalog. Similar waveform statistical features are found between detecting LFEs and tremors, which provides additional evidence tremors are composed of LFEs. The approach extracts information contained in continuous seismic waveforms that might benefit detecting precursory signals.
Expanding the environmental scope: an environment-wide association study for mental well-being
Authors: van de Weijer Margot P. , Baselmans Bart M. L. , Hottenga Jouke-Jan , Dolan Conor V. , Willemsen Gonneke , Bartels Meike 
Published: June 2021

Abstract
Background
Identifying modifiable factors associated with well-being is of increased interest for public policy guidance. Developments in record linkage make it possible to identify what contributes to well-being from a myriad of factors. To this end, we link two large-scale data resources; the Geoscience and Health Cohort Consortium, a collection of geo-data, and the Netherlands Twin Register, which holds population-based well-being data.

Objective
We perform an Environment-Wide Association Study (EnWAS), where we examine 139 neighbourhood-level environmental exposures in relation to well-being.

Methods
First, we performed a generalized estimation equation regression (N = 11,975) to test for the effects of environmental exposures on well-being. Second, to account for multicollinearity amongst exposures, we performed principal component regression. Finally, using a genetically informative design, we examined whether environmental exposure is driven by genetic predisposition for well-being.

Results
We identified 21 environmental factors that were associated with well-being in the domains: housing stock, income, core neighbourhood characteristics, livability, and socioeconomic status. Of these associations, socioeconomic status and safety are indicated as the most important factors to explain differences in well-being. No evidence of gene-environment correlation was found.

Significance
These observed associations, especially neighbourhood safety, could be informative for policy makers and provide public policy guidance to improve well-being. Our results show that linking databases is a fruitful exercise to identify determinants of mental health that would remain unknown by a more unilateral approach.
Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair
Authors: Zhang Yu , Wang Yan , Zhou Ding , Wang Kai , Wang Xu , Wang Xiang , Jiang Yang , Zhao Min , Yu Rutong , Zhou Xiuping 
Published: June 2021

AbstractAlthough radiotherapy is a well-known effective non-surgical treatment for malignant gliomas, the therapeutic efficacy is severely limited due to the radioresistance of tumor cells. Previously, we demonstrated that Yes-associated protein (YAP) promotes glioma malignant progression. However, whether YAP plays a role in radioresistance and its potential value in cancer treatment are still unclear. In this study, we found that high YAP expression is associated with poor prognosis in malignant glioma patients undergoing radiotherapy. Research in immortalized cell lines and primary cells from GBM patients revealed that YAP exhibited a radioresistant effect on gliomas via promoting DNA damage repair. Mechanistically, after radiation, YAP was translocated into the nucleus, where it promoted the expression and secretion of FGF2, leading to MAPK–ERK pathway activation.FGF2is a novel target gene of YAP. Inhibition of YAP–FGF2–MAPK signaling sensitizes gliomas to radiotherapy and prolongs the survival of intracranial cell-derived and patient-derived xenograft models. These results suggest that YAP–FGF2–MAPK is a key mechanism of radioresistance and is an actionable target for improving radiotherapy efficacy.
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV
Authors: Tang Qingying , Chen Shuxia , Wu Hui , Song Honghua , Wang Yongjun , Shi Jinlong , Wu Youjia 
Published: June 2021

AbstractCongenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate gyrus (DG) is the severely affected subregion of the hippocampus by the CH, where the dentate granule cells (DGCs) reside in. However, how CH impairs the cognitive function via affecting DGCs and the underlying mechanisms are not fully elucidated. In the present study, the CH model of rat pups was successfully established, and the aberrant dendrite growth of the DGCs and the impaired cognitive behaviors were observed in the offspring. Transcriptome analysis of hippocampal tissues following rat CH successfully identified that calcium/calmodulin-dependent protein kinase IV (CaMKIV) was the prominent regulator involved in mediating deficient growth of DGC dendrites. CaMKIV was shown to be dynamically regulated in the DG subregion of the rats following drug-induced CH. Interference of CaMKIV expression in the primary DGCs significantly reduced the spine density of dendrites, while addition of T3 to the primary DGCs isolated from CH pups could facilitate the spine growth of dendrites. Insights into relevant mechanisms revealed that CH-mediated CaMKIV deficiency resulted in the significant decrease of phosphorylated CREB in DGCs, in association with the abnormality of dendrites. Our results have provided a distinct cell type in hippocampus that is affected by CH, which would be beneficial for the treatment of CH-induced cognitive deficiency.
The role of auxin during early berry development in grapevine as revealed by transcript profiling from pollination to fruit set
Authors: Godoy Francisca , Kühn Nathalie , Muñoz Mindy , Marchandon Germán , Gouthu Satyanarayana , Deluc Laurent , Delrot Serge , Lauvergeat Virginie , Arce-Johnson Patricio 
Published: June 2021

AbstractAuxin is a key phytohormone that modulates fruit formation in many fleshy fruits through the regulation of cell division and expansion. Auxin content rapidly increases after pollination and the manipulation in its levels may lead to the parthenocarpic development. lnVitis viniferaL., little is known about the early fruit development that encompasses from pollination to fruit set. Pollination/fertilization events trigger fruit formation, and auxin treatment mimics their effect in grape berry set. However, the role of auxin in this process at the molecular level is not well understood. To elucidate the participation of auxin in grapevine fruit formation, morphological, reproductive, and molecular events from anthesis to fruit set were described in sequential days after pollination. Exploratory RNA-seq analysis at four time points from anthesis to fruit set revealed that the highest percentage of genes induced/repressed within the hormone-related gene category were auxin-related genes. Transcript profiling showed significant transcript variations in auxin signaling and homeostasis-related genes during the early fruit development. Indole acetic acid and several auxin metabolites were present during this period. Finally, application of an inhibitor of auxin action reduced cell number and the mesocarp diameter, similarly to unpollinated berries, further confirming the key role of auxin during early berry development. This work sheds light into the molecular features of the initial fruit development and highlights the auxin participation during this stage in grapevine.
Tight docking of membranes before fusion represents a metastable state with unique properties
Authors: Witkowska Agata , Heinz Leonard P. , Grubmüller Helmut , Jahn Reinhard 
Published: June 2021

AbstractMembrane fusion is fundamental to biological processes as diverse as membrane trafficking or viral infection. Proteins catalyzing membrane fusion need to overcome energy barriers to induce intermediate steps in which the integrity of bilayers is lost. Here, we investigate the structural features of tightly docked intermediates preceding hemifusion. Using lipid vesicles in which progression to hemifusion is arrested, we show that the metastable intermediate does not require but is enhanced by divalent cations and is characterized by the absence of proteins and local membrane thickening. Molecular dynamics simulations reveal that thickening is due to profound lipid rearrangements induced by dehydration of the membrane surface.
Ultrahigh energy-dissipation elastomers by precisely tailoring the relaxation of confined polymer fluids
Authors: Huang Jin , Xu Yichao , Qi Shuanhu , Zhou Jiajia , Shi Wei , Zhao Tianyi , Liu Mingjie 
Published: June 2021

AbstractEnergy-dissipation elastomers relying on their viscoelastic behavior of chain segments in the glass transition region can effectively suppress vibrations and noises in various fields, yet the operating frequency of those elastomers is difficult to control precisely and its range is narrow. Here, we report a synergistic strategy for constructing polymer-fluid-gels that provide controllable ultrahigh energy dissipation over a broad frequency range, which is difficult by traditional means. This is realized by precisely tailoring the relaxation of confined polymer fluids in the elastic networks. The symbiosis of this combination involves: elastic networks forming an elastic matrix that displays reversible deformation and polymer fluids reptating back and forth to dissipate mechanical energy. Using prototypical poly (n-butyl acrylate) elastomers, we demonstrate that the polymer-fluid-gels exhibit a controllable ultrahigh energy-dissipation property (loss factor larger than 0.5) with a broad frequency range (10−2 ~ 108 Hz). Energy absorption of the polymer-fluid-gels is over 200 times higher than that of commercial damping materials under the same dynamic stress. Moreover, their modulus is quasi-stable in the operating frequency range.
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Authors: Shakur Rameen , Ochoa Juan Pablo , Robinson Alan J. , Niroula Abhishek , Chandran Aneesh , Rahman Taufiq , Vihinen Mauno , Monserrat Lorenzo 
Published: June 2021

AbstractThe cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden cardiac death or familial cardiomyopathy. Given the disparity in patient outcomes and therapy options, we investigated the impact of variations on the intermolecular interactions across the thin filament complex as an example of an unbiased systems biology method to better define clinical prognosis to aid future management options. We present a novel unbiased dynamic model to define and analyse the functional, structural and physico-chemical consequences of genetic variations among the troponins. This was subsequently integrated with clinical data from accessible global multi-centre systematic reviews of familial cardiomyopathy cases from 106 articles of the literature: 136 disease-causing variations pertaining to 981 global clinical cases. Troponin T variations showed distinct pathogenic hotspots for dilated and hypertrophic cardiomyopathies; considering the causes of cardiovascular death separately, there was a worse survival in terms of sudden cardiac death for patients with a variation at regions 90–129 and 130–179 when compared to amino acids 1–89 and 200–288. Our data support variations among 90–130 as being a hotspot for sudden cardiac death and the region 131–179 for heart failure death/transplantation outcomes wherein the most common phenotype was dilated cardiomyopathy. Survival analysis into regions of high risk (regions 90–129 and 130–180) and low risk (regions 1–89 and 200–288) was significant for sudden cardiac death (p = 0.011) and for heart failure death/transplant (p = 0.028). Our integrative genomic, structural, model from genotype to clinical data integration has implications for enhancing clinical genomics methodologies to improve risk stratification.
A twilight for the complete nitrogen removal via synergistic partial-denitrification, anammox, and DNRA process
Authors: Ahmad Hafiz Adeel , Guo Beibei , Zhuang Xuming , Zhao Yiyi , Ahmad Shakeel , Lee Taeho , Zhu Jiegao , Dong Yuliang , Ni Shou-Qing 
Published: June 2021

AbstractThe prolonged start-up time and low total nitrogen removal of anammox hinder its full-scale application. Herein, application of nano-zerovalent iron and low strength magnetic field in sole and in combination to abbreviate the start-up period and long-term process stability of anammox was carried out. The reactor’s anammox start-up with the only magnetic field (R3) was 34 days, saving 43.3% time compared with the control. The increase of nitrogen removal efficiency over the control was 43.7% during the start-up period. However, the reactor with the coupled treatment of nano-zerovalent iron and magnetic field (R4) was more stable with higher nitrogen removal efficiency (80%) at high nitrogen loading (5.28 kg/m3/d). Anammox gene copy number in R4 was highest after 180 days of culture, followed by nano-zerovalent iron (R2) and R3 reactor. The functional genes of denitrifying bacteria (nirK and nirS) were also identified in all reactors with higher copy numbers in R2, followed by R4 and R3. Furthermore, high throughput analysis showed that the Thauera performing partial denitrification, Ignavibacterium performing dissimilatory nitrate reduction to ammonium or nitrite were also present in all reactors, more abundant in R4, confirming that the higher nitrogen removal efficiency in R4 was attributed to the synergistic relationship of other nitrogenous genera with anammox. The higher abundance of PD and DNRA in the reactor with the coupled treatment of nano-zero valent iron and magnetic field, achieved in this research, opens the opportunity of complete nitrogen removal via synergistic partial-denitrification, anammox, and DNRA (SPDAD) process.
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection
Authors: Wang Zijun , Muecksch Frauke , Schaefer-Babajew Dennis , Finkin Shlomo , Viant Charlotte , Gaebler Christian , Hoffmann Hans- Heinrich , Barnes Christopher O. , Cipolla Melissa , Ramos Victor , Oliveira Thiago Y. , Cho Alice , Schmidt Fabian , Da Silva Justin , Bednarski Eva , Aguado Lauren , Yee Jim , Daga Mridushi , Turroja Martina , Millard Katrina G. , Jankovic Mila , Gazumyan Anna , Zhao Zhen , Rice Charles M. , Bieniasz Paul D. , Caskey Marina , Hatziioannou Theodora , Nussenzweig Michel C. 
Published: June 2021

AbstractMore than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains difficult to control despite the availability of several working vaccines. Progress in controlling the pandemic is slowed by the emergence of variants that appear to be more transmissible and more resistant to antibodies1,2. Here we report on a cohort of 63 individuals who have recovered from COVID-19 assessed at 1.3, 6.2 and 12 months after SARS-CoV-2 infection, 41% of whom also received mRNA vaccines3,4. In the absence of vaccination, antibody reactivity to the receptor binding domain (RBD) of SARS-CoV-2, neutralizing activity and the number of RBD-specific memory B cells remain relatively stable between 6 and 12 months after infection. Vaccination increases all components of the humoral response and, as expected, results in serum neutralizing activities against variants of concern similar to or greater than the neutralizing activity against the original Wuhan Hu-1 strain achieved by vaccination of naive individuals2,5–8. The mechanism underlying these broad-based responses involves ongoing antibody somatic mutation, memory B cell clonal turnover and development of monoclonal antibodies that are exceptionally resistant to SARS-CoV-2 RBD mutations, including those found in the variants of concern4,9. In addition, B cell clones expressing broad and potent antibodies are selectively retained in the repertoire over time and expand markedly after vaccination. The data suggest that immunity in convalescent individuals will be very long lasting and that convalescent individuals who receive available mRNA vaccines will produce antibodies and memory B cells that should be protective against circulating SARS-CoV-2 variants.