bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging
Authors: Zhang Zhen , Ma Qiaozhi , Gao Yiyuan , Cao Lizhen , Zhu Chengcheng , Zhao Zhiwei , Zhao Jun , Zeng Linan , Lou Mingwu , Pohost Gerald M. , Li Kuncheng 
Published: July 2021

Background: Quantification of cardiac structure and function is essential for diagnostic interpretation and clinical decision making. We sought to establish cardiovascular magnetic resonance (CMR) reference values of left and right ventricular (LV and RV) morphology and function based on a large sample of healthy Chinese adults.Methods: Five hundred fifty validated healthy Chinese adults (aged 21–70 years; 323 men) free of hypertension, diabetes, and obesity were included in this study. All the subjects were stratified by gender (men and women) and age decades. On cine CMR, measurements of biventricular end-diastolic, end-systolic, and stroke volumes (EDV, ESV, and SV), ejection fraction (EF), and end-diastolic LV wall thickness (LVWT) and mass (LVM) were obtained.Results: Men had greater LVEDV (111.6 ± 19.8 vs. 94.6 ± 15.6 ml), LVESV (36.5 ± 9.8 vs. 28.2 ± 7.9 ml), LVM (121.1 ± 19.9 vs. 86.1 ± 14.5 g), global end-diastolic LVWT (8.1 ± 1.1 vs. 6.7 ± 1.0 mm), RVEDV (128.0 ± 23.6 vs. 101.7 ± 17.0 ml), and RVESV (53.5 ± 13.7 vs. 36.8 ± 8.9 ml), while women had greater LVEF (67.5 ± 5.4 vs. 70.4 ± 5.7%) and RVEF (58.5 ± 5.2 vs. 64.0 ± 5.3%) (all p &lt; 0.001). For both men and women, age was negatively correlated with LVEDV (r = −0.31 and r = −0.32), LVESV (r = −0.37 and r = −0.47), RVEDV (r = −0.31 and r = −0.29), and RVESV (r = −0.33 and r = −0.44), while it was positively correlated with LVEF (r = 0.28 and r = 0.43) and RVEF (r = 0.28 and r = 0.41) (all p &lt; 0.001). Aging was associated with increasing global end-diastolic LVWT and LVM/LVEDV in both sexes (all p &lt; 0.001). Older age was associated with increasing LVM only in women (r = 0.36, p &lt; 0.001), not in men (r = 0.05, p = 0.359).Conclusions: We systematically provide age-, sex-, and body size-specific CMR reference values for biventricular morphology and function based on a large sample of healthy Chinese adults. Biventricular structure and function are significantly associated with age and sex.
Surface Mass-Balance Gradients From Elevation and Ice Flux Data in the Columbia Basin, Canada
Authors: Pelto Ben M. , Menounos Brian 
Published: July 2021

The mass-balance—elevation relation for a given glacier is required for many numerical models of ice flow. Direct measurements of this relation using remotely-sensed methods are complicated by ice dynamics, so observations are currently limited to glaciers where surface mass-balance measurements are routinely made. We test the viability of using the continuity equation to estimate annual surface mass balance between flux-gates in the absence of in situ measurements, on five glaciers in the Columbia Mountains of British Columbia, Canada. Repeat airborne laser scanning surveys of glacier surface elevation, ice penetrating radar surveys and publicly available maps of ice thickness are used to estimate changes in surface elevation and ice flux. We evaluate this approach by comparing modeled to observed mass balance. Modeled mass-balance gradients well-approximate those obtained from direct measurement of surface mass balance, with a mean difference of +6.6 ± 4%. Regressing modeled mass balance, equilibrium line altitudes are on average 15 m higher than satellite-observations of the transient snow line. Estimates of mass balance over flux bins compare less favorably than the gradients. Average mean error (+0.03 ± 0.07 m w.e.) between observed and modeled mass balance over flux bins is relatively small, yet mean absolute error (0.55 ± 0.18 m w.e.) and average modeled mass-balance uncertainty (0.57 m w.e.) are large. Mass conservation, assessed with glaciological data, is respected (when estimates are within 1σ uncertainties) for 84% of flux bins representing 86% of total glacier area. Uncertainty on ice velocity, especially for areas where surface velocity is low (&lt;10 m a−1) contributes the greatest error in estimating ice flux. We find that using modeled ice thicknesses yields comparable modeled mass-balance gradients relative to using observations of ice thickness, but we caution against over-interpreting individual flux-bin mass balances due to large mass-balance residuals. Given the performance of modeled ice thickness and the increasing availability of ice velocity and surface topography data, we suggest that similar efforts to produce mass-balance gradients using modern high-resolution datasets are feasible on larger scales.
Thermal Regime and Variations in the Island Permafrost Near the Northern Permafrost Boundary in Xidatan, Qinghai–Tibet Plateau
Authors: Yin Guoan , Luo Jing , Niu Fujun , Lin Zhanju , Liu Minghao 
Published: July 2021

Although the thermal regime and degradation of permafrost on the Qinghai-Tibet Plateau (QTP) have been widely documented, little information exists regarding the island permafrost in the area. Ground temperatures were therefore measured for 8 years (2013–2020) at a permafrost island and at two contrasting sites in the Xidatan region to elucidate the permafrost in this area. Results indicate that the ground temperatures in the island permafrost were markedly higher than those at the same depth in the nearby marginal permafrost and the interior continuous permafrost. In addition, a distinct increasing trend was observed in the ground temperature of the island permafrost over the past 8 years, and warming was signficanty faster in the deep soil than in the topsoil, indicating a bottom–up degradation pattern in the island permafrost. Moreover, due to the persistent increase in the thickness of the active-layer and the decrease in the depth of permafrost table, the permafrost island abruptly disappeared in 2018, which may be attributed to the anomalously high air temperatures that occurred in 2016 and 2017. The results of this study may provide references for understanding of the thermal regime and degradation process of island permafrost on the QTP.
Exploring the Impact of Cerebrovascular Disease and Major Depression on Non-diseased Human Tissue Transcriptomes
Authors: Poon Chi-Lam , Chen Cho-Yi 
Published: July 2021

BackgroundThe development of complex diseases is contributed by the combination of multiple factors and complicated interactions between them. Inflammation has recently been associated with many complex diseases and may cause long-term damage to the human body. In this study, we examined whether two types of complex disease, cerebrovascular disease (CVD) or major depression (MD), systematically altered the transcriptomes of non-diseased human tissues and whether inflammation is linked to identifiable molecular signatures, using post-mortem samples from the Genotype-Tissue Expression (GTEx) project.ResultsFollowing a series of differential expression analyses, dozens to hundreds of differentially expressed genes (DEGs) were identified in multiple tissues between subjects with and without a history of CVD or MD. DEGs from these disease-associated tissues—the visceral adipose, tibial artery, caudate, and spinal cord for CVD; and the hypothalamus, putamen, and spinal cord for MD—were further analyzed for functional enrichment. Many pathways associated with immunological events were enriched in the upregulated DEGs of the CVD-associated tissues, as were the neurological and metabolic pathways in DEGs of the MD-associated tissues. Eight gene-tissue pairs were found to overlap with those prioritized by our transcriptome-wide association studies, indicating a potential genetic effect on gene expression for circulating cytokine phenotypes.ConclusionCerebrovascular disease and major depression cause detectable changes in the gene expression of non-diseased tissues, suggesting that a possible long-term impact of diseases, lifestyles and environmental factors may together contribute to the appearance of “transcriptomic scars” on the human body. Furthermore, inflammation is probably one of the systemic and long-lasting effects of cerebrovascular events.
Rigid Polyurethane Foams Containing Modified Ammonium Polyphosphate Having Outstanding Charring Ability and Increased Flame Retardancy
Authors: Yang Chunzhuang , Shao Shuiyu 
Published: July 2021

Ammonium polyphosphate (APP) with different polymerization degrees were modified by a novel phosphorus-containing organosilicon compound (PCOC), and the products obtained were coded as MAPP-30 and MAPP-1000. Then they were applied to prepare flame-retardant rigid polyurethane foam (RPUF) separately. The impact of modified APP (MAPP) on the flame-retardant properties of RPUF was investigated by the limited oxygen index (LOI) test, horizontal burning test, and cone calorimeter test. The morphologies of the char residues were observed by SEM. Furthermore, the mechanical properties of RPUF composites were measured by the compressive strength test. The results showed that whether the degree of polymerization of MAPP is 30 or 1000, they both had greater charring ability and better flame-retardant properties than unmodified APP. The residual char yield of RPUF/MAPP-30 (37.3%) and RPUF/MAPP-1000 (36.5%) were both significantly higher than RPUF/APP-30 (22.8%) and RPUF/APP-1000 (24.9%). The peak heat release rate value of RPUF/MAPP-30 was 29.9% lower than that of RPUF/APP-30, and the drop of RPUF/MAPP-1000 was 50.9% compared to RPUF/APP-1000. Moreover, the total heat release of RPUF/MAPP-1000 (9.7 MJ/m2) was much lower than that of RPUF/MAPP-30 (11.3 MJ/m2). In summary, MAPP-1000 has the best flame-retardant properties among all RPUF composites. In addition, the results also showed that flame-retardant performance and the mechanical properties dramatically decreased with the increase in the addition of MAPP-1000, and the RPUF composite had the best comprehensive performance with 20% content of MAPP-1000.
Gut Microbiota and Related Electronic Multisensorial System Changes in Subjects With Symptomatic Uncomplicated Diverticular Disease Undergoing Rifaximin Therapy
Authors: De Vincentis Antonio , Santonico Marco , Del Chierico Federica , Altomare Annamaria , Marigliano Benedetta , Laudisio Alice , Reddel Sofia , Grasso Simone , Zompanti Alessandro , Pennazza Giorgio , Putignani Lorenza , Guarino Michele Pier Luca , Cicala Michele , Antonelli Incalzi Raffaele 
Published: July 2021

Background: Intestinal dysbiosis might play a pathogenetic role in subjects with symptomatic uncomplicated diverticular disease (SUDD), but the effect of rifaximin therapy has been scantly explored with regard to gut microbiota variations in patients with SUDD.Aims: To verify to which extent rifaximin treatment affects the gut microbiota and whether an electronic multisensorial assessment of stools and breath has the potential for detecting these changes.Methods: Breath and stool samples were collected from consecutive patients with SUDD before and after a 7 days' therapy with rifaximin. Stool microbiota was assessed, and the electronic multisensorial assessment was carried out by means of the BIONOTE electronic (e-)tongue in stools and (e-)nose in breath.Results: Forty-three subjects (female 60%, median age 66 years) were included, and 20 (47%) reported clinical improvement after rifaximin therapy. Alpha and beta diversity of stool microbiota did not significantly change after treatment, while a significant variation of selected taxa was shown (i.e., Citrobacter, Coprococcus, Anaerotruncus, Blautia, Eggerthella lenta, Dehalobacterium, SMB53, and Haemophilus parainfluenzae). Overall, the electronic multisensorial system suboptimally mirrored microbiota changes, but it was able to efficiently predict patients' clinical improvement after rifaximin with accuracies ranging from 0.81 to 0.98.Conclusions: In patients with SUDD, rifaximin administration is associated with significant variation of selected taxa. While inaccurate in predicting gut microbiota change, an electronic multisensorial system, made up of e-tongue and e-nose, was able to predict clinical improvement, thus potentially qualifying as an easy and cheap tool to forecast subjects taking most likely benefit from rifaximin therapy.
Age and Gender Disparities in Adverse Events Following COVID-19 Vaccination: Real-World Evidence Based on Big Data for Risk Management
Authors: Xiong Xiaomo , Yuan Jing , Li Minghui , Jiang Bin , Lu Z. Kevin 
Published: July 2021

Background: Two coronavirus disease 2019 (COVID-19) vaccines have received emergency use authorizations in the U.S. However, the safety of these vaccines in the real-world remains unknown.Methods: We reviewed adverse events (AEs) following COVID-19 vaccination among adults in the Vaccine Adverse Event Reporting System (VAERS) from December 14, 2020, through January 22, 2021. We compared the top 10 AEs, serious AEs, along with office and emergency room (ER) visits by age (18–64 years, ≥65 years) and gender (female, male).Results: There were age and gender disparities among adults with AEs following COVID-19 vaccination. Compared to younger adults aged between 18 and 64 years, older adults were more likely to report serious AEs, death, permanent disability, and hospitalization. Males were more likely to report serious AEs, death, and hospitalization compared to females.Conclusions: COVID-19 vaccines are generally safe but possible age and gender disparities in reported AEs may exist.
Acupuncture Can Regulate the Peripheral Immune Cell Spectrum and Inflammatory Environment of the Vascular Dementia Rat, and Improve the Cognitive Dysfunction of the Rats
Authors: Pan Pan , Ma Zhinan , Zhang Zhen , Ling Zhenzhen , Wang Yao , Liu Qiuping , Lin Xiaolin , Xu Pan , Yang Dan , Zhi Hui , Wang Runmin , Zhang Xuezhu 
Published: July 2021

ObjectiveThe aim of this study is to analyze the effects of acupuncture on peripheral immune function, inflammation, and cognitive impairment in vascular dementia (VD) rats.MethodsIn this study, 2-month-old healthy male Wistar rats (260–280 g) were assigned to the groups as follows: normal group (Gn,n= 10), sham-operated group (Gs,n= 10), and operated group (Go,n= 45). The Go group was established by permanent, bilateral common carotid artery occlusion (BCCAO). Two months after operation, the operated rats were screened by hidden platform trial and the rats with cognitive dysfunction were further randomly divided into impaired group (Gi), acupoint group (Ga), and non-acupoint group (Gna) with 10 rats in each group. The Ga group was given acupuncture treatment for 14 days with a rest for every 7 days. After treatment, the Morris water maze (MWM) test was performed to evaluate the spatial learning and memory abilities of rats. The lymphocyte subsets in peripheral blood and spleen of rats were measured by flow cytometry. The levels of cytokines [i.e., interleukin (IL)-1β, IL-2, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (INF-γ)], chemokines (i.e., macrophage inflammatory protein-2 (MIP-2)), and other inflammatory mediators (i.e., cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS)) in peripheral blood and hippocampus were measured by enzyme linked immunosorbent assay (ELISA).ResultsCompared with the Gn group, the Gi rats presented long escape latencies to find the platform. After acupuncture treatment, the escape latencies of the Ga group were rescued markedly when compared with the Gi group (P&lt; 0.05). The proportion of CD4 + T lymphocytes in both spleen and peripheral blood in the Ga group increased (P&lt; 0.05) in comparison with the Gi group. There is an obvious reduction in IL-1β (P&lt; 0.05), IL-2 (P&lt; 0.05), TNF-α (P&lt; 0.01), INF-γ (P&lt; 0.01), MIP-2 (P&lt; 0.05), and iNOS (P&lt; 0.01), coming along with the increased levels of IL-4 and IL-10 (P&lt; 0.01) in the Ga group when compared with the Gi group. In addition, the hippocampus proinflammatory factors IL-1β (P&lt; 0.01), IL-2 (P&lt; 0.01), TNF-α (P&lt; 0.05), INF-γ (P&lt; 0.05), MIP-2 (P&lt; 0.05), iNOS (P&lt; 0.01), and COX-2 decreased in the Ga group, whereas the anti-inflammatory factors IL-4 and IL-10 (P&lt; 0.01) increased.ConclusionThere are abnormal immune function and peripheral inflammation in VD rats. Acupuncture can regulate the peripheral immune function and inflammation of the VD rats and can improve the cognitive dysfunction of the rats.
Arm Ergometry to Improve Mobility in Progressive Multiple Sclerosis (AMBOS)—Results of a Pilot Randomized Controlled Trial
Authors: Heinrich Inga , Rosenthal Friederike , Patra Stefan , Schulz Karl-Heinz , Welsch Götz H. , Vettorazzi Eik , Rosenkranz Sina C. , Stellmann Jan Patrick , Ramien Caren , Pöttgen Jana , Gold Stefan M. , Heesen Christoph 
Published: July 2021

Background: Walking disability is one of the most frequent and burdening symptoms of progressive multiple sclerosis (MS). Most of the exercise intervention studies that showed an improvement in mobility performance were conducted in low to moderately disabled relapsing–remitting MS patients with interventions using the legs. However, MS patients with substantial walking disability hardly can perform these tasks. Earlier work has indicated that aerobic arm training might also improve walking performance and could therefore be a therapeutic option in already moderately disabled progressive MS patients.Methods: Patients with progressive MS and EDSS 4–6.5 were randomized using a computer-generated algorithm list to either a waitlist control group (CG) or an intervention group (IG). The IG performed a 12-week home-based, individualized arm ergometry exercise training program. Maximum walking distance as measured by the 6-min walking test (6MWT) was the primary endpoint. Secondary endpoints included aerobic fitness, other mobility tests, cognitive functioning, as well as fatigue and depression.Results: Of n = 86 screened patients, 53 with moderate disability (mean EDSS 5.5, SD 0.9) were included and data of 39 patients were analyzed. Patients in the IG showed strong adherence to the program with a mean of 67 (SD 26.4) training sessions. Maximum work load (Pmax) increased in the training group while other fitness indicators did not. Walking distance in the 6MWT improved in both training and waitlist group but not significantly more in trained patients. Similarly, other mobility measures showed no differential group effect. Cognitive functioning remained unchanged. No serious events attributable to the intervention occurred.Conclusion: Although maximum work load improved, 3 months of high-frequency arm ergometry training of low to moderate intensity could not show improved walking ability or cognitive functioning in progressive MS compared to a waitlist CG.The study was registered at www.clinicaltrials.gov (NCT03147105) and funded by the local MS self-help organization.
Optical Coherence Tomography Reveals Longitudinal Changes in Retinal Damage Under Different Treatments for Neuromyelitis Optica Spectrum Disorder
Authors: Zeng Pei , Du Chen , Zhang Rui , Jia Dongmei , Jiang Feng , Fan Moli , Zhang Chao 
Published: July 2021

Background: Progressive retinal neuroaxonal damage after acute optic neuritis may occur in neuromyelitis optica spectrum disorder (NMOSD). However, it is unclear if treatments used to prevent attacks influence neurodegeneration.Objectives: We aimed to investigate retinal damage in patients treated with disease-modifying drugs in a longitudinal study.Methods: We retrospectively included 50 patients with aquaporin 4-antibody-seropositive NMOSD. Peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell complex (mGCC) thickness, total macular volume (TMV), and optic disc measures were acquired by spectral domain optical coherence tomography in patients treated with tocilizumab, rituximab, and azathioprine.Results: Longitudinally, in eyes with a history of ON (NMOSDON+), we observed annual thinning of mGCC [tocilizumab: −1.77 (−3.44, −0.09) μm, p = 0.041; rituximab: −2.03 (−3.58, −0.48) μm, p = 0.017; azathioprine: −1.79 (−2.22, −1.37) μm, p &lt; 0.001], and pRNFL [tocilizumab: −2.07 (−0.75, −3.39) μm, p = 0.005; rituximab: −2.18 (−0.36, −4.00) μm, p = 0.023; azathioprine: −2.37 (−0.98, −3.75) μm, p = 0.003], reduced TMV [tocilizumab: −0.12 (−0.22, −0.01) mm3, p = 0.028; rituximab: −0.15 (−0.21, −0.08) mm3, p = 0.001; azathioprine: −0.12 (−0.20, −0.04) mm3, p = 0.006], and increased cup area [tocilizumab: 0.08 (−0.01, 0.16) mm2, p = 0.010; rituximab: 0.07 (0.01, 0.12) mm2, p = 0.019; azathioprine: 0.14 (0.02, 0.26) mm2, p = 0.023]. However, we detected no significant differences in annual changes in mGCC, pRNFL, TMV, and cup area between patients with tocilizumab, rituximab, and azathioprine in NMOSDON+ eyes. NMOSDON− eyes did not display mGCC or pRNFL thinning in patients treated with tocilizumab and rituximab. Intriguingly, we observed significant thinning of mGCC in patients treated with azathioprine compared with tocilizumab [−0.84 (−1.50, −0.18) μm vs. −0.19 (−0.87, 0.48) μm, p = 0.012] and rituximab [−0.84 (−1.50, −0.18) μm vs. −0.07 (−1.25, −2.51) μm, p = 0.015] in NMOSDON− eyes.Conclusions: This study demonstrated that retinal ganglion cell loss is independent of ON attacks in NMOSD. Tocilizumab and rituximab may delay mGCC thinning in NMOSDON− eyes compared with azathioprine.
Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer
Authors: Zhao Chongru , Hu Weijie , Xu Yi , Wang Dawei , Wang Yichen , Lv Wenchang , Xiong Mingchen , Yi Yi , Wang Haiping , Zhang Qi , Wu Yiping 
Published: July 2021

Obesity is defined as a chronic disease induced by an imbalance of energy homeostasis. Obesity is a widespread health problem with increasing prevalence worldwide. Breast cancer (BC) has already been the most common cancer and one of the leading causes of cancer death in women worldwide. Nowadays, the impact of the rising prevalence of obesity has been recognized as a nonnegligible issue for BC development, outcome, and management. Adipokines, insulin and insulin-like growth factor, sex hormone and the chronic inflammation state play critical roles in the vicious crosstalk between obesity and BC. Furthermore, obesity can affect the efficacy and side effects of multiple therapies such as surgery, radiotherapy, chemotherapy, endocrine therapy, immunotherapy and weight management of BC. In this review, we focus on the current landscape of the mechanisms of obesity in fueling BC and the impact of obesity on diverse therapeutic interventions. An in-depth exploration of the underlying mechanisms linking obesity and BC will improve the efficiency of the existing treatments and even provide novel treatment strategies for BC treatment.