bluuebunny/crossref_metadata_2025_split huggingface dataset:
Front Cover
Authors: Memeo Roberto , Paiè Petra , Sala Federico , Castriotta Michele , Guercio Chiara , Vaccari Thomas , Osellame Roberto , Bassi Andrea , Bragheri Francesca 
Published: March 2021

AbstractIn our work we present an optofluidic‐based microscope on chip for 3D imaging of Drosophila embryos with dual color capabilities. The cover image shows the device during experimental validation along with the acquired images of two different embryos which are automatically optically sectioned while flowing in the microfluidic channel. The frames reveal internal volumetric features of the specimens.Further details can be found in the article by Roberto Memeo, Petra Paiè, Federico Sala, Michele Castriotta, Chiara Guercio, Thomas Vaccari, Roberto Osellame, Andrea Bassi, and Francesca Bragheri (e202000396).
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Inside Cover
Authors: Chandra Roy Abhijit , Bangalore Subramanya Shreyas , Manohar Rudresh Shoorashetty , Venkataraman Venkatakrishnan 
Published: March 2021

AbstractThe work demonstrates an on chip optofluidic surface deformable liquid Dove prism (LDP) based low‐fluid flow pressure monitoring device. The smart design of the device in combination with the property of liquid and soft solid enabled by the TIR makes the sensor highly sensitive. The applicability of the sensor is validated by capturing and analyzing respiratory pressure signals of some human subjects at numerous conditions.Further details can be found in the article by Abhijit Chandra Roy, Shreyas Bangalore Subramanya, Shoorashetty Manohar Rudresh, and Venkatakrishnan Venkataraman (e202000381).
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Beyond the rule of transition state: Identification of roaming routes in some cases of carbonyl compounds
Authors: Lin King‐Chuen , Tso Cheng‐Jui , Kasai Toshio 
Published: March 2021

AbstractThis account focuses on photodissociation of carbonyl compounds to verify a so‐called roaming route, alternative to those passing through a transition state (TS) invoked in the realm of the kinetics of elementary chemical processes. Such a roaming route bypasses the minimum energy path but produces the same molecular products. The photodissociation of the carbonyl compounds of study includes methyl formate (HCOOCH3), formic acid (HCOOH), and aliphatic aldehydes (RCOH, RH, CH3, and large alkyl group). Methyl formate and formic acid were promoted to the excited state, followed by internal conversion via a conical intersection. Then, the energetic precursor dissociated to fragments, which proceeded along either TS or roaming path. As the excitation energy increases, the roaming fraction in methyl formate is significantly interfered with by an open channel of triple fragmentation (H + CO + CH3O), whereas such a channel may not occur in formic acid even at an excitation wavelength of 193 nm. As a distinct roaming type, aliphatic aldehydes are found to possess the structure of the roaming saddle point comprising two moieties weakly bound at a distance. The energy difference between the TS barrier and the roaming saddle point is indicative of the extent for the roaming contribution. The roaming route becomes increasingly dominant when the aliphatic aldehyde is larger. Experimentally, ion imaging was employed to visualize the rotational‐level dependence of the roaming route, while time‐resolved Fourier‐transform infrared emission spectroscopy was applied to determine the vibrational‐state dependence. The roaming signature was verified theoretically by quasi‐classical trajectory calculations. As an alternative, a multi‐center impulsive model was developed to simulate the roaming scalar and vector properties without involving the global energy surface.
Broadening the perspective on youth's systems of support: An ecological examination of supportive peer and adult relationships during adolescence
Authors: Melton Theresa N. , Brehm Margaret V. , Deutsch Nancy L. 
Published: March 2021

AbstractThis study applies the theory of positive youth development (Lerner et al., 2010) and the youth systems framework (Varga & Zaff, 2018) to the examination of supportive peer and adult relationships across multiple contexts in which youth develop. Results of egocentric social network analysis indicated that high school‐aged youth nominated significantly more adults than middle school‐aged youth. Peers and adults both acted as important sources of support, although often the types of support they offer differ. Outdegree centrality of peers was a significant predictor of character. The size of a participant's youth system, measured as the number of contexts accessed, along with average closeness in adult relationships, was a significant predictor of contribution. Thematic analysis of interview data identified four themes, aligned with the five actions of developmental relationships, as contributing factors to youth–adult closeness and youth perceptions of support (Pekel et al., 2018). Implications for youth–adult relationships are discussed.
RFX1‐mediated CCN3 induction that may support chondrocyte survival under starved conditions
Authors: Mizukawa Tomomi , Nishida Takashi , Akashi Sho , Kawata Kazumi , Kikuchi Sumire , Kawaki Harumi , Takigawa Masaharu , Kamioka Hiroshi , Kubota Satoshi 
Published: March 2021

AbstractCellular communication network factor (CCN) family members are multifunctional matricellular proteins that manipulate and integrate extracellular signals. In our previous studies investigating the role of CCN family members in cellular metabolism, we found three members that might be under the regulation of energy metabolism. In this study, we confirmed that CCN2 and CCN3 are the only members that are tightly regulated by glycolysis in human chondrocytic cells. Interestingly, CCN3 was induced under a variety of impaired glycolytic conditions. This CCN3 induction was also observed in two breast cancer cell lines with a distinct phenotype, suggesting a basic role of CCN3 in cellular metabolism. Reporter gene assays indicated a transcriptional regulation mediated by an enhancer in the proximal promoter region. As a result of analyses in silico, we specified regulatory factor binding to the X‐box 1 (RFX1) as a candidate that mediated the transcriptional activation by impaired glycolysis. Indeed, the inhibition of glycolysis induced the expression of RFX1, and RFX1 silencing nullified the CCN3 induction by impaired glycolysis. Subsequent experiments with an anti‐CCN3 antibody indicated that CCN3 supported the survival of chondrocytes under impaired glycolysis. Consistent with these findings in vitro, abundant CCN3 production by chondrocytes in the deep zones of developing epiphysial cartilage, which are located far away from the synovial fluid, was confirmed in vivo. Our present study uncovered that RFX1 is the mediator that enables CCN3 induction upon cellular starvation, which may eventually assist chondrocytes in retaining their viability, even when there is an energy supply shortage.
CDH1 variants leading to gastric cancer risk management decision‐making experiences in emerging adults: ‘I am not ready yet’
Authors: Liu Yi , Calzone Kathleen , Fasaye Grace‐Ann , Quillin John 
Published: March 2021

AbstractPathogenic/likely pathogenic variants (PLPV) in CDH1 are associated with a significantly increased lifetime risk for diffuse gastric cancer, with an average age of onset of 47 years. CDH1 PLPV carriers are recommended to have prophylactic total gastrectomy (PTG) or routine endoscopy surveillance. Emerging adults (EAs) may have unique circumstances that affect their medical management decision‐making about PTG versus endoscopy. The study aim was to use qualitative interpretative phenomenological analysis method to understand the lived experience and medical management decision‐making process for EAs carrying a CDH1 PLPV. Eligible participants were unaffected CDH1 PLPV carriers, ages 18 to 29, who had not undergone PTG and had discussed CDH1 medical management with a health provider. Semi‐structured telephone interviews were transcribed verbatim and analyzed for major themes. Results show EAs wanted to avoid developing diffuse gastric cancer, but most do not feel they are ready for PTG. They had worries about PTG related to their identity exploration, financial stability, and careers. Most did not want to pass the PLPV to their children; however, the cost of preimplantation genetic testing with in vitro fertilization was a concern. Family medical history and self‐understanding of endoscopy and PTG highly influenced medical management decision‐making. Understanding of diffuse gastric cancer detection rate using endoscopy was inconsistent among participants. Body image was not a concern for most, but they worry about dietary restrictions after PTG. Lastly, connection to peers having the same experience was important. These findings increase our understanding of the medical management decision‐making challenges for EA CDH1 carriers. EAs may take an extended time to decide what option is right for them. Thus, genetic counseling for CDH1 PLPV EA carriers requires long‐term support and education.
Impact of cytoreductive surgery on survival of patients with low‐grade serous ovarian carcinoma: A multicentric study of Turkish Society of Gynecologic Oncology (TRSGO‐OvCa‐001)
Authors: Vatansever Dogan , Taskiran Cagatay , Mutlu Meydanli Mehmet , Gungorduk Kemal , Akbayir Ozgur , Yalcin Ibrahim , Demirkiran Fuat , Sozen Hamdullah , Ozgul Nejat , Celik Husnu , Onan Mehmet Anil , Taskin Salih , Oge Tufan , Simsek Tayyup , Abboud Sara , Yuksel Ilkbal Temel , Ayhan Ali 
Published: March 2021

AbstractBackground and ObjectivesThe aim of this study was to analyze the factors affecting recurrence‐free (RFS) and overall survival (OS) rates of women diagnosed with low‐grade serous ovarian cancer (LGSOC).MethodsDatabases from 13 participating centers in Turkey were searched retrospectively for women who had been treated for stage I–IV LGSOC between 1997 and 2018.ResultsOverall 191 eligible women were included. The median age at diagnosis was 49 years (range, 21–84 years). One hundred seventy‐five (92%) patients underwent primary cytoreductive surgery. Complete and optimal cytoreduction was achieved in 148 (77.5%) and 33 (17.3%) patients, respectively. The median follow‐up period was 44 months (range, 2–208 months). Multivariate analysis showed the presence of endometriosis (p = .012), lymphovascular space invasion (LVSI) (p = .022), any residual disease (p = .023), and the International Federation of Gynecology and Obstetrics (FIGO) stage II–IV disease (p = .045) were negatively correlated with RFS while the only presence of residual disease (p = .002) and FIGO stage II–IV disease (p = .003) significantly decreased OS.ConclusionsThe maximal surgical effort is warranted for complete cytoreduction as achieving no residual disease is the single most important variable affecting the survival of patients with LGSOC. The prognostic role of LVSI and endometriosis should be evaluated by further studies as both of these parameters significantly affected RFS.
Potential of novel colchicine dosage schedule for the palliative treatment of advanced hepatocellular carcinoma
Authors: Lin Zu‐Yau , Yeh Ming‐Lun , Huang Ching‐I , Chen Shinn‐Cherng , Huang Chung‐Feng , Huang Jee‐Fu , Dai Chia‐Yen , Yu Ming‐Lung , Chuang Wan‐Long 
Published: March 2021

AbstractPrevious in vitro and in vivo experiments had demonstrated dose‐dependent anti‐cancer effects of clinical plasma colchicine concentrations on hepatocellular carcinoma (HCC) cells. This phase IIa trial was to evaluate the potential efficiency and safety of our novel colchicine dosage schedule for the palliative treatment of advanced HCC. The dosage schedule started from oral intake of 1 mg colchicine three times per day for 4 days and discontinuation in the following 3 days (one cycle). The treatment cycle was repeated and the dosage was adjusted ranging from 3 to 1.5 mg/day according to the condition of the participant. The control group was originated from chart review of 86 HCC patients treated by sorafenib for more than 2 months. Fifteen participants signed the inform consent. Two participants were excluded due to screening failure in one and less than four treatment cycles in another. For severe adverse events, the colchicine group demonstrated higher incidence of biliary tract obstruction (p = 0.0184) than the sorafenib group. Comparison grade 1 or 2 adverse events between two groups, the colchicine group had higher incidence of diarrhea (p = 0) and the sorafenib group had higher incidence of palmar‐plantar erythrodysesthesia syndrome (p = 0.0045). There was no significant difference in mortality, median survival, and overall survival between two groups (all p > 0.2). In conclusion, our novel colchicine dosage schedule is clinically feasible and has the potential to be applied in the palliative treatment of advanced HCC especially based on the cost‐effectiveness consideration.
Control of Burn Wound Infection by Methylene Blue‐Mediated Photodynamic Treatment With Light‐Emitting Diode Array Illumination in Rats
Authors: Ishiwata Naoto , Tsunoi Yasuyuki , Sarker Roma Rani , Haruyama Yasue , Kawauchi Satoko , Sekine Yasumasa , Onuma Chinami , Tsuda Hitoshi , Saitoh Daizoh , Nishidate Izumi , Sato Shunichi 
Published: March 2021

Background and ObjectivesControl of burn wound infection is difficult due to the increase in drug‐resistant bacteria and deteriorated immune responses. In this study, we examined the usefulness of methylene blue (MB)‐mediated antimicrobial photodynamic therapy (aPDT) with illumination by a light‐emitting diode (LED) array for controlling invasive infections from the wound to inside the body for rats with an extended deep burn infected with Pseudomonas aeruginosa.Study Design/Materials and MethodsAn MB solution with the addition of ethanol, ethylene‐diamine‐tetra‐acetic acid disodium salt, and dimethyl sulfoxide was used as a photosensitizer (PS). An extended deep burn was made on the dorsal skin in rats and the wounds were infected with P. aeruginosa. The rats were divided into three groups: control (no treatment; n = 14), PS mixture application alone (PS alone group; n = 10), and aPDT group (n = 14). For aPDT, after the PS mixture was applied onto the surface of infected wounds, the wounds were illuminated with a 665‐nm LED array at an intensity of 45 mW/cm2 three times per treatment, with an illumination duration of 20 minutes and an interval of 10 minutes. The treatment was repeated each day for 7 consecutive days (day 0–day 6). Bacterial numbers on the wound surface and the weights and survival rates of the animals were evaluated daily. At the endpoints, bacterial numbers in the liver and blood were counted. Since the PS mixture showed high dark toxicity against P. aeruginosa in vitro, the influence of the PS mixture application onto healthy skin was also examined in vivo.ResultsEven in the aPDT group, rapid bacterial regrowth was observed on the wound surface after each day's treatment, but the geometric mean values of the bacterial numbers before and after each aPDT were considerably lower than those in the control group. Application of the PS mixture alone showed a clear bactericidal effect only at day 0, which is attributable to the formation of biofilms after day 1. Rats in the aPDT group showed a smaller weight loss, a higher ratio of no bacterial migration at the endpoints, and significantly higher survival rates than those in the other two groups. Effects of repeated application of the PS mixture onto healthy skin were not evident.ConclusionsApplication of MB‐mediated aPDT with illumination by a high‐intensity LED array daily for seven consecutive days was effective for suppressing invasive infection from the wound to inside the body in rats with an extensive deep burn infected with P. aeruginosa, resulting in significant improvement of their survival. Lasers Surg. Med. © 2021 Wiley Periodicals LLC
Comparative neurological safety of fluoroquinolones versus therapeutic alternatives
Authors: Ellis Darcy E. , Hubbard Rebecca A. , Willis Allison W. , Zuppa Athena F. , Zaoutis Theoklis E. , Hennessy Sean 
Published: March 2021

AbstractBackgroundFluoroquinolones, one of the most commonly prescribed antibiotic classes, have been implicated in cases of central nervous system (CNS) and peripheral nervous system (PNS) adverse events, which highlights the need for epidemiologic studies of the neurological safety of fluoroquinolones.PurposeTo evaluate the safety of fluoroquinolones with regard to risk of diagnosed neurological dysfunction.MethodsWe conducted a propensity score‐matched inception cohort study using claims data from a commercially insured population. Our study included adults prescribed an oral fluoroquinolone or comparator antibiotic between January 2000 and September 2015 for acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, uncomplicated urinary tract infection, or acute bronchitis. Our outcomes were CNS dysfunction, and four separate but complementary PNS dysfunction outcomes. Cox proportional hazards models were estimated after matching on propensity scores fitted using the variables age, sex, epilepsy, hereditary peripheral neuropathy, renal dysfunction, diabetes, gabapentinoid use, statin use, isoniazid use, and chemotherapy use.ResultsOur cohort contained 976 568 individuals exposed to a fluoroquinolone antibiotic matched 1:1 with a comparator. Matching produced balance (standardized mean difference <0.1) on all variables included in the propensity score. The hazard ratio associated with fluoroquinolone exposure was 1.08 (95% confidence interval 1.05–1.11) for CNS dysfunction, and 1.09 (95% CI 1.07–1.11) for the most commonly occurring PNS dysfunction outcome.ConclusionsFluoroquinolone antibiotic use was associated with the development of neurological dysfunction versus comparator antibiotic use in the adult population.
Release behaviors and kinetics of coated bead‐on‐string nanofibrous multilayer membranes loaded with drug particles
Authors: Li Tingxiao , Huang Yifan , Wang Lei , Xin Binjie 
Published: March 2021

AbstractA bead‐on‐string structure with special beads at the microscale level could act as an effective carrier for solid drug particles as well as giving a continuous and sustained release profile. Tetracycline hydrochloride (TCH), used as solid model drug particles, was ground to obtain nanoscale and well‐distributed size. Electrospun poly[lactic‐co‐(glycolic acid)] (PLGA) bead‐on‐string nanofibers loaded with TCH of different particle sizes were fabricated for controlled drug delivery. The morphology of TCH particles and bead‐on‐string nanofibers were observed using a particle sizer and scanning electron microscopy. The effects of drug particle size on the release behaviors of nanofibers were further investigated and analyzed using UV–visible spectrophotometry. In vitro release results suggested that bead‐on‐string nanofibers encapsulating ground TCH particles had higher total drug release quantity compared with unground particle‐loaded nanofibers. Coating of the surface of PLGA/TCH nanofibers was investigated for controlled‐release effects and the release mechanism to understand the drug–polymer carrier interaction. The results indicated that coating on both sides of nanofibrous membranes could effectively decrease the initial burst release. Bead‐on‐string nanofibers proved to be promising mats for drug delivery applications. © 2021 Society of Industrial Chemistry.
Engaged or excluded: LGBTQ youth's participation in school sports and their relationship to psychological well‐being
Authors: Clark Caitlin M. , Kosciw Joseph G. 
Published: March 2021

AbstractSports participation has been shown to positively affect youth well‐being. However, research has also shown that sports environments can be unsafe for lesbian, gay, bisexual, transgender, and queer (LGBTQ) youth. Using data from a large study on school‐related experiences of LGBTQ secondary students who reported on their extracurricular activities in school, (N = 15,813), this study examined LGBTQ youth's participation in school sports, the effects of participation on well‐being and school belonging, and whether any such benefits of participation varied by transgender status and gender binary identity. Over a quarter of LGBTQ respondents in our study had participated in school sports, and being transgender and being nonbinary were related to a lower likelihood of sports participation. Transgender males and transgender nonbinary youth had the lowest likelihood of sports participation. In general, LGBTQ youth who participated in sports had increased well‐being and greater school belonging. However, in regard to self‐esteem, transgender nonbinary youth appeared to have greater benefit from participating in sports than did their transgender male and transgender female peers. Considering these results, schools have a responsibility to ensure that school sports are safe and welcoming for LGBTQ youth.
Math homework purpose scale: Confirming the factor structure with high school students
Authors: Xu Jianzhong 
Published: March 2021

AbstractThe present investigation aims to test the validity of scores on the math homework purpose scale (MHPS) for high school students. Factorial results found that the MHPS contained three subscales: academic purpose, self‐regulatory purpose, and approval‐seeking purpose. Furthermore, the MHPS had a sufficient level of measurement and latent factor mean invariance across gender and grade level. Additionally, the MHPS had adequate coefficient alpha and omega coefficients. Regarding its validity evidence, consistent with theoretical predictions, the MHPS was associated positively with homework effort and completion. In summary, our investigation presents strong evidence showing that the MHPS is a valid tool for use with high school students.
Disparities in cystic fibrosis survival in Mexico: Impact of socioeconomic status
Authors: Bustamante Adriana E. , Fernández Lucía T. , Rivas Lissette C. , Mercado‐Longoria Roberto 
Published: March 2021

AbstractBackgroundMedian survival age in cystic fibrosis (CF) has increased in developed countries. Scarce literature exists about survival in Latin America, especially in Mexico. The aim of our study was to assess the median age of survival in CF patients and the impact of risk factors in Mexico over a 20‐year period.MethodsWe conducted a retrospective study with all patients registered and followed in the CF Center in Monterrey, Mexico from 2000 to 2020. Median survival age was the primary outcome, assessed with Kaplan–Meier analysis. The influence of clinical, biological, and demographic factors on survival was analyzed with Cox regression model.ResultsTwo‐hundred five patients were included. Median survival for the cohort was 21.37 years (95% confidence interval [CI], 17.20–25.55). In the multivariate Cox regression model, low socioeconomic status (hazard ratio [HR], 4.21; 95% CI, 2.43–7.27), chronic Pseudomonas aeruginosa infection at 6 years (HR, 10.45; 95% CI, 5.66–19.28), and pancreatic insufficiency (HR, 3.13; 1.38–7.13) were independent risk factors for mortality.ConclusionMedian survival in Mexican patients with CF is lower than in high‐income countries, and socioeconomic status plays a conspicuous role in the disparity. To increase patient survival for those residing in low‐middle income countries, public health authorities must design policies that fully cover diagnosis and treatment strategies for the CF population.