bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routine dynamics in virtual teams: the role of technological artifacts
Authors: Baralou Evangelia , Dionysiou Dionysios D. 
Published: September 2021

PurposeIn this paper, the authors extend their understanding of the internal dynamics of routines in contexts characterized by increased levels of virtuality. In particular, the authors focus on the role of routine artifacts in the internal dynamics of routines to answer the question: How does extensive reliance on information and communication technologies (ICTs) due to physical distance influence the internal dynamics of the new product development (NPD) routine (i.e. interactions between performative, ostensive and artifacts of routines) enacted by a virtual team?Design/methodology/approachThis paper is based on an 18-month ethnographic study of the NPD routine performed by a virtual team. The authors relied predominantly on qualitative, ethnographic data collection and analysis methods, using semi-structured interviews, non-participant observation, and the collection of archival data and company documents (formal procedures, guidelines, application designs etc). Qualitative research offers a valuable means to investigate dynamic processes in organizations due to its sensitivity to the organizational context and potential to focus on activities as they unfold.FindingsThe findings highlight the central role of routine artifacts (ICTs) in the routine dynamics of the NPD routine performed by virtual team. In particular, the authors show that the use of the particular types of ICTs enabled team members to confidently and meaningfully relate to the overall routine activity and coordinate their actions in a context characterized by physical distance and extensive reliance on communication and collaboration technologies.Originality/valueThe paper sheds light into role of routine artifacts in the routine dynamics in a context characterized by a high degree of virtuality. This work contributes to the literature on routine dynamics by theorizing about the processes through which routine artifacts (ICTs) afforded routine participants the ability to act confidently and meaningfully to the present and dynamically coordinate their actions with their fellow routine participants.
Effect of multilateral trade liberalization on services export diversification
Authors: Gnangnon Sena Kimm 
Published: September 2021

PurposeThis study investigates the effect of multilateral trade liberalization on services export diversification with a view to complementing the recently published work on the effect of multilateral trade liberalization on export product diversification.Design/methodology/approachThe empirical exercise been performed using a panel dataset of 133 countries over the period 1995–2014.FindingsThe findings show that multilateral trade liberalization is associated with greater services export diversification in both developed and developing countries alike. This is particularly the case in countries with a high reliance on manufactured goods exports or those that enjoy greater export product diversification. Interestingly, multilateral trade liberalization enhances services export diversification in countries that experience higher foreign direct investment inflows.Research limitations/implicationsThese findings highlight the importance of multilateral trade liberalization for services export diversification. The study has considered explicitly supply-side factors that could affect services export diversification. This is because the indicator of multilateral trade liberalization is highly correlated with some demand-side factors, such as the world demand for services exports. Therefore, another avenue for future research could involve looking at the demand side factors that could influence services export diversification, and whether the degree of multilateral trade liberalization matters for the influence of these demand factors on services export diversification.Practical implicationsThe current study through its positive effect on both export product diversification and services export diversification, greater cooperation among World Trade Organization (WTO) Members on trade matters could help revive economic growth, particularly in the current COVID-19 pandemic that has significantly plummeted it.Originality/valueTo the best of our knowledge, this is first study that has investigated this issue.
Motivations of choosing archival studies as major in the iSchools: viewpoint between two universities across the Pacific Ocean
Authors: Ng Tracy Chui Wan , Chiu Dickson K.W. , Li KIng Kwan 
Published: September 2021

PurposeThis study explores the learning and career motivation of the students who have chosen archival studies as their major in their master's degree programs, which has scant prior research.Design/methodology/approachThe authors use a qualitative interview method to investigate the students' opinions and underlying reasons. Nine students from the University of Hong Kong (HKU) and University of British Columbia (UBC), both members of the iSchools, were interviewed. Considering the responses and research questions, the authors applied content analysis techniques to summarize data gathering from interviews into five themes to better interpret the meanings behind them.FindingsDespite different development stages of archives sectors in Hong Kong and Canada, the learning and career motivation factors of these students from both universities share some similar characteristics and can also be divided into intrinsic factors (such as personal interests, personalities) and extrinsic factors (such as prior working experience, working environment, nature of archives work and development of the archives field). Both intrinsic and extrinsic factors significantly influenced them in choosing archival studies as major in their graduate studies.Practical implicationsThese findings can help educators and professions review and improve the curricula as well as promote the profession to the public and attract more people to pursue their studies in the archives field.Originality/valueScant studies discussed the career development and education motivation of archivists, especially related to Asia.
CircSAMD11 facilitates progression of cervical cancer via regulating miR‐503/SOX4 axis through Wnt/β‐catenin pathway
Authors: Pan Qiwen , Meng Xia , Li Jianxiang , Qin Xiaoni , Chen Huifeng , Li Yueqing 
Published: September 2021

AbstractCervical cancer (CC) is a common gynaecological malignant tumour with a high mortality rate. Circular RNAs (circRNAs) play a critical role in tumour occurrence and development. This study aimed to investigate the function and molecular basis of hsa_circ_0009189 (circSAMD11) in CC development. RNA levels were determined by qRT‐PCR, and protein expression was measured by western blot. Cell proliferation, migration, invasion and apoptosis were detected by Cell Counting Kit‐8 (CCK‐8), colony formation, Transwell and flow cytometry assays. The relationship between miR‐503 and circSAMD11/SOX4 was validated via dual‐luciferase reporter assay, RIP or RNA pull‐down assay. Xenograft assay was conducted to test tumour growth in vivo. CircSAMD11 and SOX4 levels were elevated, while miR‐503 level was reduced in CC tissues and cells. Knockdown of circSAMD11 suppressed CC cell proliferation, migration and invasion and accelerated apoptosis. CircSAMD11 was localised in cytoplasm and directly targeted miR‐503. Also, circSAMD11 sponged miR‐503 to modulate SOX4 expression. Additionally, circSAMD11 regulated CC progression via absorbing miR‐503 or modulating SOX4. Besides, depletion of circSAMD11 hindered tumorigenesis in vivo. CircSAMD11 contributed to CC progression by regulating miR‐503/SOX4 signalling and activating Wnt/β‐catenin pathway, which provides a promising therapeutic target for cervical cancer.
The Wood Image Analysis and Dataset (WIAD): Open‐access visual analysis tools to advance the ecological data revolution
Authors: Rademacher Tim , Seyednasrollah Bijan , Basler David , Cheng Jian , Mandra Tessa , Miller Elise , Lin Zuid , Orwig David A. , Pederson Neil , Pfister Hanspeter , Wei Donglai , Yao Li , Richardson Andrew D. 
Published: September 2021

Abstract

Ecological data are collected and shared at an increasingly rapid pace, but it is often shared in inconsistent and untraceable processed forms. Images of wood contain a wealth of information such as colours and textures but are most commonly reduced to ring‐width measurements before they can be shared in various common file formats. Archiving digital images of wood samples in libraries, which have been developed for ecological analysis and are publicly available, remains the exception.

We developed the Wood Image Analysis and Dataset (WIAD), an open‐source application including a web interface to integrate basic visual analysis of wood samples, such as increment cores, thin sections or X‐ray films, basic data processing, and archiving of the images and derived data to facilitate transparency and reproducibility in studies using visual characteristics of wood.

WIAD provides user‐friendly tools to manipulate images of wood samples, mark and measure wood characteristics such as growth increments, density fluctuations, early‐ and latewood widths and fire scars, and to visualise, process and archive images, metadata, and the derived data.

WIAD constitutes a step towards the reproducible automation of tree‐ring analysis while establishing an open‐source foundation to create improved community‐developed repositories which would enable novel ecological studies harnessing the wealth of existing visual data.
Live surgery of colorectal endometriosis broadcasted from a surgeon’s routine operating theater is not associated with higher complications rate
Authors: Roman Horace , Prosszer Maria , Marabha Jamil , Merlot Benjamin , Forestier Damien , Noailles Myriam , Marpeau Loïc , Tuech Jean‐Jacques 
Published: September 2021

AbstractIntroductionAlthough live surgeries are routinely included in surgical congress programs, they are the subject of an ongoing debate in terms of patient safety and teaching value. The goal of our study was to assess the risk of postoperative complications related to live surgery broadcast from the surgeon's routine theater, in patients managed for deep endometriosis infiltrating the digestive tract.Material and methodsWe report a retrospective comparative study, enrolling women managed for colorectal endometriosis by a gynecologic surgeon, from September 2013 to March 2020 in two referral centers. We compared the rate of postoperative bowel fistula in women managed during live surgery in the routine operating theater, with that observed in women for whom surgery was not broadcast.ResultsAmong 813 women, 33 (4.1% of cases) underwent surgical procedures transmitted live to various conference rooms located outside the hospital and were compared with 780 patients who underwent non‐broadcast surgery. Women's age, body mass index, past surgical and obstetrical history, and major preoperative complaints were comparable. Cases presented with impaired constipation score, more frequent sciatic pain, and infiltration of the vagina, whereas overall revised American Fertility Society classification scores were more severe in controls. The rate of rectal nodules over 3 cm in size was comparable between the two groups (72.7% in cases vs. 72.1% in controls). Operative time was also comparable (153 ± 52 minutes vs. 148 ± 79 minutes). Cases were more frequently managed by disk excision of rectal nodules (63.7% vs. 30.3%), and more frequently involved the sacral plexus (18.2% vs. 7.3%). Postoperative complications were comparable between the two groups, in terms of bowel fistula (3% in the live surgery group vs. 4.1% in controls), pelvic abscess requiring secondary laparoscopy (3% vs. 4.9%), or bladder dysfunction requiring self‐catheterization after discharge (6.1% vs. 5.3%).ConclusionsPerforming laparoscopic management of colorectal endometriosis with live transmission of surgery from a surgeon's routine operating theater, is not related to a higher risk of major postoperative complications.
Tectonic and climatic controls on the Late Jurassic–Early Cretaceous stratigraphic architecture of the Xuanhua basin, North China
Authors: Lin Chengfa , Liu Shaofeng , Tian Cheng , Zhuang Qitian , Li Ruiwei , Tan Maojin , Steel Ronald J. 
Published: September 2021

AbstractArguments for recognizing autogenic vs. allogenic signals in the stratigraphic record are still far from settled, as is the decoding of unsteady allogenic responses to climate vs. tectonic forcing. We offer the case of late Mesozoic Xuanhua basin in the western Yanshan fold‐and‐thrust belt of North China to make these points. The study area is an intramontane basin that has allowed detailed structural, sedimentological, and provenance analyses in a kilometre‐thick succession (the Tuchengzi Formation) of alluvial fan, fluvial, lake‐delta and lacustrine deposits. Extensive geological mapping provided confidence of near‐basinwide later correlation of strata, revealing two large‐scale upward‐coarsening (CU) successions each 80–240 m thick, with prominent vertical changes from lacustrine through deltaic and fluvial to alluvial fan deposits. Two intervals of thrust‐related growth strata identified in the Tuchengzi Fm suggest that the CU successions were the signals of tectonic uplift and accommodation change related to Likouquan and the Mapu thrusting. In the lower CU succession, there is a stacking (30+) of small‐scale (3–16 m thick) upward‐fining cyclothems that are argued to have been generated by alternating wet‐dry climate cycles. The wet half‐cycle is argued to have initiated with high sediment and water discharge of flood‐generated mass flows into the lake and ended with accumulation of lacustrine mudstones as lake level rose. The lake deposits include the maximum flooding during the wet half‐cycle. The dry half‐cycle was characterized by continued lacustrine deposits, but increased evidence of subaerial exposure (rooting, paleosols, and mudcracks) argued to result from falling of the lake level under dry conditions.
Notch down‐regulation and inflammatory cytokines and RANKL overexpression involvement in peri‐implant mucositis and peri‐implantitis: A cross‐sectional study
Authors: Milinkovic Iva , Djinic Krasavcevic Ana , Nikolic Nadja , Aleksic Zoran , Carkic Jelena , Jezdic Marija , Jankovic Sasha , Milasin Jelena 
Published: September 2021

AbstractObjectivesNotch signaling pathway, known to influence bone resorption in several oral diseases, has not been analyzed in peri‐implantitis yet. Therefore, the aims of the present study were to determine the levels of Notch cascade, bone remodeling mediators, and pro‐inflammatory cytokines, in conjunction with clinical parameters, in subjects with peri‐implant mucositis and peri‐implantitis.Material and methodsClinical parameters: peri‐implant probing depth, bleeding on probing, suppuration on probing, and plaque index (PI) were recorded. Samples were collected from 130 participants, divided into peri‐implantitis (PI), peri‐implant mucositis (PM), and healthy implants (HI) group. Relative expression levels (REL) of Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF‐α, IL‐17, IL‐1β, IL‐6, RANKL, and OPG mRNA were determined by reverse transcriptase‐real‐time polymerase chain reaction. Quantitation of Notch 1, Il‐17, and IL‐6 proteins was performed using ELISA assays.ResultsAll clinical parameters were significantly higher in PI compared to HI. Significant decrease of Notch 1, and higher REL of Hey 1, IL‐1β, IL‐6, and RANKL were found in PI compared to HI. PM showed significant increase of IL‐1β REL in comparison with HI. In PI versus PM, significantly higher REL was found for Hey 1, TNF‐α, IL‐17, IL‐1β, IL‐6, and RANKL. Additionally, higher protein concentrations of IL‐6 and IL‐17 were detected in PI versus PM and versus HI group.ConclusionThe combined effect of Notch 1 down‐regulation and elevated expression of some key inflammation modulators might result in osteoclast activity increase and subsequent osteolysis in peri‐implantitis.
Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca2+ entry
Authors: Zhang Lu yao , Lin Meng , Qingrui Zhuan , Zichuan Wang , Junjin Li , Kexiong Liu , Xiangwei Fu , Yunpeng Hou 
Published: September 2021

AbstractObjectivesThe alteration of bioenergetics by oocytes in response to the demands of various biological processes plays a critical role in maintaining normal cellular physiology. However, little is known about the association between energy sensing and energy production with energy‐dependent cellular processes like meiosis.Materials and methodsWe demonstrated that cell cycle‐dependent mitochondrial Ca2+ connects energy sensing to mitochondrial activity in meiosis progression within mouse oocytes. Further, we established a model in mouse oocytes using siRNA knockdowns that target mitochondrial calcium uniporters (MCUs) in order to inhibit mitochondrial Ca2+ concentrations.ResultsDecreased numbers of oocytes successfully progressed to the germinal vesicle stage and extruded the first polar body during in vitro culture after inhibition, while spindle checkpoint‐dependent meiosis was also delayed. Mitochondrial Ca2+ levels changed, and this was followed by altered mitochondrial masses and ATP levels within oocytes during the entirety of meiosis progression. Abnormal mitochondrial Ca2+ concentrations in oocytes then hindered meiotic progress and activated AMP‐activated protein kinase (AMPK) signalling that is associated with gene expression.ConclusionsThese data provide new insight into the protective role that MCU‐dependent mitochondrial Ca2+ signalling plays in meiotic progress, in addition to demonstrating a new mechanism of mitochondrial energy regulation by AMPK signalling that influences meiotic maturation.
Paradoxical outcome of heart transplantation associated with institutional case volume
Authors: Yang Zhizhou , Subramanian Melanie P. , Yan Yan , Schilling Joel D. , Puri Varun , Itoh Akinobu 
Published: September 2021

AbstractBackgroundPrevious studies in heart transplantation have shown an association between institutional case volume and outcomes. We aim to determine the case volume associated with optimal 1‐year survival after transplantation.Methods and resultsThe United Network for Organ Sharing (UNOS) national database was analyzed for adult patients who underwent orthotopic heart transplantation between January 2013 and December 2017. A total of 11,196 cases at 128 transplant centers were included. Risk‐adjusted restricted cubic splines revealed a non‐linear association between institutional case volume and 1‐year post‐transplant survival. In the risk‐adjusted, random‐effect Cox model with segmented linear splines, higher heart transplant volume up to 24 cases per year was associated with better 1‐year survival (HR = .978 every additional case, 95% CI .963–.993), and optimal survival was maintained between 24 and 38 cases per year. However, further increase in volume above 38 transplants per year was associated with mildly decreased 1‐year survival (HR = 1.007 every additional case, 95% CI 1.002–1.013).ConclusionsThe relationship between institutional case volume and heart transplant 1‐year survival is non‐linear, with optimal survival observed at institutional case volume of 24–38 cases per year.
Combination of arterial lactate levels and Cv‐aCO2/Da‐vO2 ratio to predict early allograft dysfunction after liver transplantation
Authors: Sáez de la Fuente Ignacio , Sáez de la Fuente Javier , Molina Collado Zaira , Chacón Alves Silvia , Sánchez‐Bayton Griffith María , Lesmes González de Aledo Amanda , Barea Mendoza Jesús , Sánchez‐Izquierdo Riera José Ángel , García de Lorenzo Abelardo , Montejo González Juan Carlos 
Published: September 2021

AbstractPurposeWe examined the ability of the P(v‐a)CO2/Da‐vO2 ratio combined with elevated lactate levels to predict early allograft dysfunction (EAD).Materials and methodsPatients were classified into four groups according to lactate levels and P(v‐a)CO2/Da‐vO2 ratio: Group 1; lactate >2.0 mmol/L and P(v‐a)CO2/Da‐vO2 ratio >1.0; Group 2; lactate >2.0 mmol/L and P(v‐a)CO2/Da‐vO2 ratio <1.0; group 3; lactate<2.0 mmol/L and P(v‐a)CO2/Da‐vO2 ratio >1.0; group 4; lactate<2.0 mmol/L and P(v‐a)CO2/Da‐vO2 ratio <1.0. We defined EAD according to Olthoff criteria.ResultsOne‐hundred and fifty patients were included. EAD occurred in 41 patients (27.3%), and was associated with worse graft survival at 1 year (92% vs. 73%; P = ,003) as well as a higher re‐transplantation rate (4,6% vs. 17,1%; P = ,019). The multivariate analysis revealed that P(v‐a)CO2/Da‐vO2 ratio at T6 [OR 7.05(CI95% 2.77–19.01, P<.001)] was an independent predictor for EAD. Belonging to group 1 at 6 h was associated with worse clinical outcomes but no association was found with 1‐year graft survival or 1‐year patient survival.ConclusionsIn this single center, prospective, observational study in patients who received an OLT, we found that elevated lactate levels combined with a high Cv‐aCO2/Da‐vO2 after 6 h was associated with the development of EAD and worse clinical outcomes in the early postoperative period.
Longitudinal profiling of plasma and urine metabolites during liver regeneration in living liver donors
Authors: Bottiglieri Teodoro , Wang Xuan , Arning Erland , Fernandez Hoylan , Wall Anji , McKenna Greg , Ruiz Richard , Onaca Nicholas , Trotter James , Lawrence Michael , Naziruddin Bashoo , Asrani Sumeet K. , Testa Giuliano 
Published: September 2021

AbstractBackgroundKnowledge of metabolic processes affected by major hepatectomy (MHx), and the metabolic pathways involved in liver regeneration and recovery of function, is limited and mainly derived from animal models. Assessment of restoration of hepatic function is essential in human living liver donors (LD).MethodsWe used a targeted metabolomic approach to longitudinally quantify changes in plasma and urine biomarkers from healthy LD. The biomarkers were analyzed before MHx and at scheduled intervals up to 12 months thereafter.ResultsMarked changes were found in the concentration of 15 primary and secondary plasma bile acids. Most significant changes occurred 2 days after MHx and persisted for up to 3 months. In addition, there were significant changes in acylcarnitine, phospholipid, and amino acid metabolism. The sum of aromatic amino acids and the Fischer ratio, both metabolic markers of liver damage, and the symmetrically demethylated arginine to arginine ratio, a marker of kidney function, were affected.ConclusionsThis is the first comprehensive longitudinal study investigating metabolic processes during recovery of liver function after MHx in LD. It provides further evidence of full restoration of metabolic processes 3 months after MHx and supports future investigation to understand how metabolic changes affect donors’ hepatic function.