bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the risk of comorbidity onset in elderly patients after a cancer diagnosis
Authors: Islam Md Tamzid , Saif Md Saiful Islam , Alam Naima , Pepper Sam , Ratnayake Isuru , Mudaranthakam Dinesh Pal 
Published: February 2025

Abstract

Background
Cancer is a critical disease that affects a person physically, mentally, socially, and in many other aspects. During the treatment stage of cancer, patients suffer from various health complexities, especially elderly people, which might result in the onset of other diseases development of a comorbid condition. Several studies have shown comorbidity plays a crucial role in cancer survival. However, there remains a lack of comprehensive statistical techniques at the national level studies to assess the significance of comorbidities development in cancer. Our research aims to address this gap by comparing cancer and non-cancer individuals over four years’ time period.

Methods
The Health Retirement Study (HRS) data was used to extract information from 6651 participants aged more than 50. Within a 4-year time span, cross-sectional observations were created whether comorbidities or not based on the development of diseases such as high blood pressure, diabetes, heart disease, stroke, lung disease, and psychological disease.

Results
In the multivariable regression model, we observed higher chances of developing comorbidity (OR = 1.321, p-value 0.0051) among the cancer group compared to the non-cancer group, adjusting the socio-economic factors. Moreover, the socio-economic factors were found to be significantly associated with cancer leading to applying the propensity score matching with (1:3 matching). Finally, the balanced data also showed significantly higher chances of developing comorbidity (OR = 1.294, p-value 0.0207) among cancer patients.

Conclusions
The above findings demonstrated the imperative development of enhanced treatment protocols, which prioritize the overall health of cancer patients, thereby reducing their susceptibility to additional illnesses.
Weight bias among students and employees in university settings: an exploratory study
Authors: Sohier Léonie , Brearty Claudia Mc , LeBlanc Stéphanie , Chartrand Dominic J. , St-Laurent Audrey , Spahis Schohraya , Philibert Léonel , Mangliar Inès Auclair , Gagnon-Girouard Marie-Pierre , Lakritz Clara , Iceta Sylvain 
Published: February 2025

Abstract

Background
Weight bias and stigmatization are highly prevalent in modern society, especially in educational settings, such as universities. Despite extensive documentation of the adverse consequences on students’ daily functioning and psychological health, there is limited literature regarding factors associated with weight bias and its extent in Quebec universities.

Objectives
This exploratory study aims to assess the prevalence of weight bias and experiences of weight-related stigmatization, as well as to examine their associations with gender, psychological health problems, and status (students or employees) in a college environment in the province of Quebec.

Methods
Participants were recruited via their university emails. A total of 292 students and 129 university employees participated in an online survey distributed via the secure REDCap platform. The following data was collected: sociodemographic information, status (students or employees), body weight, experiences of stigma, and prejudice towards people living with a higher weight (Fat Phobia Scale; FPS).

Results
Approximately half of the respondents reported experiencing weight-related stigma (44.7%), and half indicated holding prejudice towards overweight people (51.1%), with a moderate rate of bias according to the FPS (3.25). Experience of weight-related stigma was found to be associated with gender (X
2 = 7.88, p = 0.019), and a higher prevalence of psychological health problems (X
2 = 9.41, p = 0.002), while having prejudice was associated with gender, with men scoring higher at the FPS (F = 7.64, p = 0.006), but not with the status (student or employee). The regression model identified significant effects of status [F(4, 347) = 2.856, p = 0.005] and the interaction between gender and status [F(4, 347) = -2.326, p = 0.021] on the FPS scores.

Conclusions
Various factors are associated with the experience of weight bias and stigmatization towards people with higher weight in the college population. Campaigns to prevent and reduce weight-related bias should be aimed specifically at staff members as well as students. Future research should examine weight bias internalization as a mediator between self-perceived weight and prejudice.
Nursing graduates’ perceived future career pathway and career shift tendency in Egypt: a cross sectional study
Authors: Kotp Mohamed Hashem , Aly Mohamed Ahmed , Ismail Hossam Aly , Elmoaty Aliaa Ezz Eldin Abd , Basyouny Hasan Ahmed Awad 
Published: February 2025

Abstract

Purpose
Addressing the dynamics shaping nurses’ career trajectories and strategies to support workforce stability and retention in the healthcare sector. The aim of this study was to explore nursing graduates’ perceptions of their future Career pathways, and their tendency toward career shifts. Additionally, the study examined the factors influencing career shift tendencies and the relation between career pathway perceptions and career shift tendencies.

Methods
A descriptive cross-sectional study was used, with an online distributed questionnaire for study participants from different nursing graduates’ categories. That included demographic characteristics, a section that measured nursing graduates’ future career pathway perception, and career shift tendency.

Results
Nursing graduates in Egypt were having a positive perception regarding their future career pathway. However, more than one quarter of them were considering career shift represents potential workforce instability and dissatisfaction within the nursing profession and financial factors was one of the main provoking drivers for career shift tendency. In addition, nursing graduates’ perception of career pathway had a significant effect on their career shift tendency in future.

Conclusion
Based on the findings of this study, further efforts should be made to confront nursing shortage in Egypt, implementing targeted interventions to support nursing graduates in navigating their career pathways. Additionally, proactive measures should be taken to address the identified factors driving intentions to leave the profession, such as improving workplace conditions, fostering intergenerational collaboration, and offering mentorship programs. These strategies are essential for fostering a resilient and satisfied nursing workforce and ensuring the delivery of high-quality patient care in the healthcare sector.
An outbreak of Ralstonia insidiosa in hospitalized children
Authors: Copana-Olmos Raul , Calderon-Lopez Maria Elena , Ledezma-Hurtado Wara , Ramos-Cardenas Roxana , Calle-Cruz Hirma , Cano-Guzman Fatima 
Published: February 2025

Abstract

Introduction
Healthcare-associated infections (HAIs) pose significant public health challenges, increasing patient morbidity, mortality, and healthcare costs. This study analyzes an outbreak of Ralstonia insidiosa in children admitted to a pediatric referral hospital, focusing on implemented control and prevention measures.

Methods
A prospective observational study was conducted during the outbreak, emphasizing control measures in a pediatric hospital.

Results
Eighteen cases were reported over 19 epidemiological weeks, with an attack rate of 8.79% in pediatric intensive care units (PICU) patients and 1.76% of those in other wards. The affected children were primarily those hospitalized for over 14 days, with invasive devices, admitted to PICU, and having underlying conditions. Symptoms included vomiting, fever, and cough. Outbreak control was achieved through epidemiological and antimicrobial surveillance measures.

Conclusions

Ralstonia insidiosa is an emerging nosocomial pathogen associated with risk factors such as invasive devices and prolonged PICU stays. Effective control measures, leveraging available resources, can mitigate outbreaks.
Postoperative endophthalmitis treatment with antibiotics associated or not with pars plana vitrectomy: a randomized clinical trial
Authors: Bergamo Vinicius Campos , Nakayama Luis Filipe , de Moraes Nilva Simeren Bueno , Tavares Ivan Maynart , De Queiroz Campos Mauro Silveira , Hofling-Lima Ana Luisa , Maia Maurício 
Published: February 2025

Abstract

Background
Postoperative endophthalmitis (PSE) is a severe ocular complication that can lead to irreversible vision loss or even globe atrophy. The Endophthalmitis Vitrectomy Study (EVS) historically guided PSE management but is increasingly questioned due to advances in pars plana vitrectomy (PPV) techniques and its narrow focus on cataract surgery. This study aimed to compare PPV followed by intravitreal antibiotic injection at the end of surgery (PPV + IVAIES) with intravitreal antibiotic injection alone (IVAI) in managing PSE.

Methods
This randomized clinical trial included 35 pseudophakic patients with PSE following cataract extraction, anti-vascular endothelial growth factor (anti-VEGF) injections, or glaucoma surgeries. Participants were randomized to receive either PPV + IVAIES (n = 12) or IVAI (n = 23). Best-corrected visual acuity (BCVA) was assessed at baseline and days 7, 30, 60, and 90 post-intervention. Clinical worsening, defined as lack of improvement or progression of symptoms within 48–72 h, guided retreatment protocols. Group A (PPV + IVAIES) received repeat IVAI if required, while Group B (IVAI) underwent delayed PPV with repeat IVAI. Statistical significance was assessed using repeated measures ANOVA and logistic regression.

Results
Both groups showed significant BCVA improvement (p < 0.001). PPV + IVAIES resulted in faster recovery, with superior BCVA at day 7 (p = 0.019) and day 30 (p = 0.041). Retreatment was required in 39.1% of the IVAI group but not in the PPV + IVAIES group (p = 0.015). Subgroup analysis indicated a trend toward better early outcomes with early PPV (p = 0.029).

Conclusions
Early PPV + IVAIES provides faster visual recovery and reduces retreatment rates compared to IVAI alone. Multicenter studies are warranted to confirm these findings and refine clinical guidelines.

Trial registration ClinicalTrials.gov identifier: NCT04192994.
Outbreak of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Indonesia in 2023–2024
Authors: Ashique Sumel , Srivastava Shriyansh , Sridhar Sathvik Belagodu , Kumar Sachin , Rahaman Abdul S. K. , Hussain Md Sadique , Mohanty Aroop , Sah Sanjit , Mehta Rachana 
Published: February 2025

Abstract

Graphical Abstract
Use of dornase alfa in the management of life-threatening mucostasis in airway stents: its efficacy and safety
Authors: Turan Demet , Chousein Efsun Gonca Ugur , Cortuk Mustafa , Elkhatroushi Burcu Babaoğlu , Ozgul Mehmet Akif , Cetinkaya Erdogan 
Published: February 2025

Abstract

Purpose
Airway stents (AS) are a last-resort treatment for central airway obstructions when airway patency cannot be maintained above 50%, in patients unsuitable for surgery, or with recurrence after surgery. However, AS placement can cause complications, including life-threatening mucostasis, which is challenging to manage. Standard methods to prevent mucus retention often have limited efficacy. Dornase alfa, a mucolytic agent widely used in cystic fibrosis (CF) patients, has shown efficacy in secretion control in mechanically ventilated pediatric non-CF patients. This study evaluates the efficacy and safety of nebulized dornase alfa in managing AS-related life-threatening mucostasis.

Results
Fourteen patients (mean age 56.3 ± 15.6 years) with life-threatening mucostasis were identified among 255 stented patients (2017–2019). Eight had Y-shaped stents, and 6 had non-Y-shaped stents (5 hourglass and 1 OKI); 13 stents were placed for benign conditions and 1 for malignancy. Mucus grades (defined by Marchese et al.) and the number of bronchoscopies needed 6 months before and after dornase alfa were evaluated. Statistically significant decreases were observed in both mucus grades (2.36 ± 0.49 to 0.79 ± 0.59, p < 0.001) and the number of bronchoscopies per patient (3.21 ± 0.89 to 2.00 ± 1.04, p = 0.002). The shape of AS and the presence of bronchiectasis on thoracic computed tomography scans had no significant impact on mucostasis development. No side effects related to dornase alfa were observed.

Conclusion
Dornase alfa significantly reduced mucus burden and bronchoscopic interventions in AS-related life-threatening mucostasis, demonstrating its safety and efficacy for managing this complication.
Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration
Authors: Hyland Victoria , Iovine M. Kathryn 
Published: February 2025

ABSTRACT
This study provides new insights into the molecular pathways dictating skeletal patterning during zebrafish fin regeneration. Connexin43 (Cx43) is known to influence skeletal patterning by inhibiting evx1 expression and thereby regulating the timing of joint formation. Here, we demonstrate that cellular communication network factor 2 (ccn2a) also contributes to this pathway. We find that Ccn2a appears to act downstream of Cx43 and similarly inhibits joint formation by inhibiting evx1 expression. Pharmacological inhibition of β-catenin demonstrates that ccn2a is likely regulated by β-catenin. Additionally, this paper provides evidence that Yap signaling contributes to joint formation through regulating ccn2a. These findings provide novel insights into the role of Ccn2a during skeletal patterning.
Khdrbs1 drives re-differentiation of bipotential progenitor cells by inhibiting p53 in zebrafish biliary-mediated liver regeneration
Authors: Gang Kai , Chen Qi , Sun Junhui , Zhang Tingwei , Cai Pengcheng , Ni Rui , Ma Jianlong 
Published: February 2025

ABSTRACT
After severe liver injury, biliary epithelial cells (BECs) undergo de-differentiation into bipotential progenitor cells (BPPCs), which subsequently re-differentiate into nascent hepatocytes and BECs to accomplish liver regeneration. However, the crucial factors governing the re-differentiation process of BPPCs remain largely unknown. Here, using a zebrafish model of severe liver injury, we observed specific expression of khdrbs1a and khdrbs1b (collectively known as khdrbs1) in BPPCs through single-cell RNA analyses and fluorescence in situ hybridization. Subsequently, to eliminate the genetic compensation, we generated a CRISPR/dead Cas9-mediated system for interfering with khdrbs1 in BECs, which caused defective liver regeneration and impaired re-differentiation of BPPCs. Furthermore, the khdrbs1−/− mutant displayed impaired proliferation and re-differentiation of BPPCs during liver regeneration. Mechanistically, p53 signaling was activated in response to the loss of khdrbs1, and tp53 mutation partially rescued the defective liver regeneration of the khdrbs1−/− mutant. In summary, we conclude that Khdrbs1 promotes the re-differentiation of BPPCs in part by inhibiting p53 activation during biliary-mediated liver regeneration in zebrafish.
Selling Data to Marketers
Authors: Guo Liang 
Published: February 2025

The supply and the demand for data analytics are growing rapidly. Recent years have seen a surge in the availability of massive consumer data and in the emergence of data sellers (e.g., brokers and intermediaries). Unlike standard products, the value of data analytics for marketers depends on how their business decisions can be enabled and improved. In this paper, we investigate how a monopoly seller can offer a menu of data-based service plans to screen heterogenous marketers that can decide whether to take an action (e.g., direct selling, targeting, lending) with uncertain value and privately known cost. We characterize how, and for which marketers, the provision of information may be distorted in the optimal design. We present conditions under which optimally supplied information can be socially excessive or insufficient. It is shown that selling data appends may yield double reversals in the optimal service plans, in comparison with those when the seller’s offerings serve as marketing lists (i.e., the action is infeasible under the marketers’ outside option). We articulate how these results are coherently driven by the same underlying mechanism regarding how the marginal value of information is endogenously derived from the improvement in the marketers’ decision making over their default action. We also examine how our results can be enriched in alternative settings on the production and the costs of information. This paper was accepted by Dmitri Kuksov, marketing.
Dermatological assessment: history-taking and examination
Authors: Alsararatee Hasan H 
Published: February 2025

Nurses of all disciplines will find dermatological complaints one of the most common presentations in their practice. This article looks at effective techniques when assessing dermatological conditions. Skin problems are common, affecting up to one-third of the population during their lifetime, and they are frequently encountered by advanced clinical practitioners (ACPs) in both primary and secondary care settings. Despite the prevalence of dermatological presentations, ACPs often feel unprepared to conduct a thorough dermatological history and examination. This article aims to provide guidance to trainees and qualified ACPs, whether in acute hospital settings or primary care, to perform dermatological assessments and examinations systematically. This is the first article in a two-part series on dermatological assessment.
Event conflation in high stakes testing: a comparison of usage and relationship to writing scores by language types
Authors: Spring Ryan 
Published: February 2025

Abstract
Talmy (1985. Lexicalization patterns: Semantic structure in lexical form. In Timothy Shopen (ed.), Language typology and syntactic description, vol. 3, 36–149. Cambridge, MA: Cambridge University Press, 1991. Path to realization: A typology of event conflation. In Proceedings of the 17th annual meeting of the Berkeley Linguistics Society, 480–519. Berkeley Linguistics Society) introduced the concept of event conflation: that two micro events can be conceptualized and expressed as a single macro event. He proposed a linguistic typology based on ths concept, and second language acquisition studies have suggested that learners whose first language is of a different type than their target language have extra difficulty interpreting and reproducing event conflation in the target language phrases. However, the degree to which using conflation patterns similar to the first language in one’s target language impedes communication is still unclear. To observe the effect of first and second language type mismatches on communicative ability, data was taken from the independent writing task of the TOEFL iBT® Public Use Dataset and the Event Conflation Finder was used to extract and analyze instances of path encoding. Framing tendencies and correlations between these tendencies and rater scores were compared amongst learners whose first languages are often argued to be one of the three major types: satellite-framed, mixed-framed, and verb-framed. I found that only learners with verb-framed first languages exhibited a clear pattern of correlation between typical satellite-framing patterns and rater scores, suggesting that satellite-framed expressions are more difficult for learners whose first language is verb-framed.
Relevance and Rigour with Qualitative Entrepreneurship Research: A Literature-Review Based Discussion
Authors: Leick Birgit , Tuitjer Gesine 
Published: February 2025

Abstract
As qualitative empirical entrepreneurship research is increasingly gaining momentum, and newly emerging research streams are pushing commonly applied methods to their epistemological limits, such entrepreneurship studies often have issues regarding their rigour, because important onto-epistemological aspects, such as the positionality of the researcher in the research process, are not duly considered. At the same time, qualitative empirical entrepreneurship studies are highly popular, implying a high level of their relevance. This conceptual article discusses how scholars may perform relevant qualitative empirical entrepreneurship research rigorously by combining two methods. To this aim, the article discusses important methodological challenges and opportunities for qualitative empirical entrepreneurship research, in general, and, based upon both a discussion of the methods studied and a systematic literature review, compares the utility of the methods for the qualitative empirical toolbox, which widely applies the Gioia protocol. This comparison of methods, including the Gioia protocol, allows conclusions on increasing both the relevance and rigour of qualitative empirical entrepreneurship research.
Assessing the effectiveness of utilizing low-cost inertial measurement unit sensors for producing as-built plans
Authors: Kamel Abdullah 
Published: February 2025

Abstract
As-built mapping using terrestrial sensors is crucial for accurately documenting the final state of building structures. However, conventional methods often face limitations in urban environments, such as obstructions and the need for clear sightlines. This study evaluates the effectiveness of the low-cost Moasure ONE Inertial Measurement Unit sensor for producing as-built plans, addressing challenges associated with traditional surveying methods like total stations. The research investigates the Moasure ONE’s capabilities in terms of cost, time efficiency, flexibility, and productivity, while adhering to the USA Federal Geographic Data Committee and American Society for Photogrammetry and Remote Sensing accuracy standards. The methodology includes a statistical study, data manipulation, georeferencing, and quality assessment using ground control points. Results indicate that Moasure ONE can achieve a horizontal positional accuracy (RMSEH1) of 17.7 cm, aligning with the required tolerances for detailed mapping. The findings suggest that Moasure ONE offers significant advantages over traditional methods, including reduced survey time and increased detail capture, making it a viable alternative for professional surveying tasks in construction and engineering projects.
Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction
Authors: Mishra Riya 
Published: February 2025

Abstract

Objectives
Thus, the study was designed to assess the ability of ICA to ameliorate MTX-induced renal toxicity in rats and determine the pathogenetic pathways of oxidative stress, inflammation, and apoptosis.

Methods
Mtx renal toxicity was developed following an intraperitoneal administration of 20 mg/kg MTX. ICA was orally given at 100 mg/kg/day for two consecutive weeks. Experimental indicators included: biochemical renal function – BUN, SCr; and oxidative stress – SOD, GSH-Px, MDA. Other histological studies included immunohistochemical staining for Nrf2 and HO-1, QPCR of pro-inflammatory cytokines and biomarker of kidney injury, and TUNEL assay to assess the protective effects affiliated with ICA.

Results
In an animal model treated with MTX, renal damage was reflected by increased oxidative stress, inflammatory-borne cytokines, and apoptotic indices. ICA treatment ameliorated these effects to a great extent by reversing changes in antioxidant enzyme activities, suppressing lipid peroxidation and regulating the Nrf2/HO-1 pathway. This was evidenced by the decrease in pro-inflammatory and kidney injury genes in the ICA-treated groups but by significant histological ameliorations of kidney structure. TUNEL assay proved the decreased apoptotic index in kidney tissue.

Conclusions
These findings exhibited the therapeutic efficacy of ICA for attenuating renal injury from MTX and established that it mainly exerts its cytoprotective effects through the Nrf2/HO-1 pathway.