bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respuesta de la industria 4.0 a las necesidades de una sociedad cada vez más conectada
Authors: Baquero Villamil Giovanny Alexander , Mahecha Tafur Manuel Alejandro 
Published: October 2021

This article is about the transformation of industry and society through globalization, the internet, and the use of new technologies in regards to the industry's development. Also, considering opportunities that respond to the needs of society, creating effects that acknowledge these trends in the configuration of production processes. This article aims to describe how industry 4.0 replies to the needs of the connected society. A literature review was carried out to set data analysis from contrasting visions or approaches. It was concluded that contemporary society may be defined as techno-dependent, which does not imply any positive either negative connotation, but which does define several consumption characteristics to which industry 4.0 must adapt quickly and constantly.
Complementary and alternative medicine use in the prevention of COVID-19 pandemic: a cross-sectional survey in Kerala, India
Authors: Mini G. K. , Grace Chitra A. , Jinbert Lordson 
Published: October 2021

Background: Globally, there is evidence of increased Complementary and alternative medicine (CAM) use during epidemics, and pandemics. Recent studies have shown that there is an increased use of CAM during the coronavirus disease (COVID-19) pandemic. The aim of the study was to investigate the pattern of CAM practice in the prevention of COVID-19 pandemic among adults in Kerala state, India.Methods: This was a cross-sectional descriptive study conducted in the first week of June 2021 among adults residing in Kerala state. The study used a pre-tested google form to collect the data. A total of 548 individuals aged 18-84 years answered an online questionnaire for the present study.Results: A higher proportion (52.4%) of participants were aged <30 years, 30.8% were males, 55.3% rural residents, 26.6% health care professionals, and 51.1% had a regular income. CAM use prevalence was 59.3% (95% CI: 55.1 to 63.3). Social media (46.9%) was the most frequently reported source of CAM. The age-adjusted analysis results showed that CAM use was higher among health professionals (OR: 2.15, 95% CI: 1.41-3.27), those who did not believe that vaccine could prevent coronavirus (OR: 1.91 CI: 1.08-3.39), and those who were having no regular income (OR: 1.56, CI: 1.04-2.34), compared to their counterparts.Conclusions: Close to 60% of CAM use in this population is a public health concern since the efficacy of CAM use for the prevention or treatment of COVID-19 is not known. The CAM users will be under a sense of false protection, which is likely to negate vaccination and seeking proper treatment for COVID -19 in Kerala.
Educative booklet for elders with type 2 diabetes mellitus
Authors: George Nenmanikkara Geoviya , Moosabba M. S. , Sivakumar M. R. , Suvarna Manjula 
Published: October 2021

Background: Consistently following and practicing the instructions given in the educational booklets helps in the disease awareness and its management.Methods: The study was developed by formulating the booklet content; content selection and source reference; framing the content; artfully crafting the pictures; booklet layout; approval by the specialist and audience; modifying and proofreading. For content validation, the item-level content validity index (I-CVI) score and scale level content validity index (S-CVI) score of minimum 0.80 was considered.Results: The booklet was created by focusing on 5 main aspects namely information about the disease and the importance about the lifestyle changes, exercises, advices that needs to be considered while exercising, footcare and fall prevention techniques. The recommendations made by the experts and the participants were accepted and incorporated in the booklet. The mean I-CVI and S-CVI scores are >0.90. The booklet was easy to read, understand and apply by the experts and participants.Conclusions: The results indicated that validated booklet can be considered as a useful educational tool for promoting the wellness among the elders with type 2 diabetes mellitus.
Awareness of ergonomics for online teaching in school teachers
Authors: Baheti Radhika S. , Ray Manish M. , Shyam Ashok , Sancheti Parag 
Published: October 2021

Background: Musculoskeletal disorders (MSDs) have been a well-known health issue in many occupations and its incidence among school teachers is particularly high. The teachers were thrown into a “new normal” of working from home offices because of the COVID-19 pandemic. Online teaching invites its own set of musculoskeletal aches and pains accompanied with eye strain and even hoarseness of voice or discomfort in the throat caused due to speaking for hours at a stretch. Teachers teaching online have to work in a sitting posture for extended periods of time, gaze at the screens of the computer/mobile constantly throughout the task, speak continuously for most hours of their work and make voice modulations for them to be clearly audible over the connection. Hence, this study was conducted to find out the awareness of various ergonomic principles in school teachers conducting online lectures.Methods: The study included 97 participants within the age group of 20-58 years (38.35±10.50) who were sent the Self-made questionnaire via online platform. The questionnaire included several closed ended questions about the ergonomic principles, sitting postures and workstation set ups. The information so obtained was documented and converted into a computer based spread sheet for data analysis. Results: Based on the results obtained, the participants showed reduced levels of ergonomic awareness.Conclusions: The study therefore concluded that the teachers had reduced levels of ergonomic awareness.
Knowledge and practices towards road safety measures among intern and resident doctors: a cross-sectional study
Authors: Das Bishnu Ram , Bora Sampurna , Das Arpan Kumar , Kakoti Gitali 
Published: October 2021

Background: In spite of ongoing commitment and efforts, road traffic accidents continue to be a leading cause of death and disabilities in India. Adequate knowledge on road safety measures among budding doctors can create awareness and provide preventive counselling to their clients. An attempt was made to assess the knowledge and practices about road safety measures among intern and resident doctors working in tertiary care setting.Methods: An institution based cross-sectional study was conducted among 168 young doctors of Jorhat Medical College, Jorhat, Assam.Results: Among the enrolled study participants 54% were intern and 46% were resident doctors. More than half of the participants were male. Knowledge on different, road signs among the young doctors ranges in between 68% to 99%. The dangerous effects of alcohol consumption while driving/riding were known to 93% of the participants. While riding two wheels, only 58% always use helmet with belt and 33% sometimes use mobile phone. Regarding exceed in speed limit in two wheels, 11 (17%) participants informed that they surpass the speed limit and among them 10 (26%) were males which was found to be statistically significant. Among four-wheelers, 48% always use seat belt and 49% sometimes use mobile phone while driving. During four-wheel driving, 21% participants were involved in occasional drinking/smoking and it was found significantly higher in males.Conclusions: The study revealed that in spite of having adequate knowledge about road safety measures, intern and resident doctors are poor in practicing which warrant motivational and counselling intervention.
Clinico-epidemiological profile of palmoplantar dermatoses in northeast India
Authors: S. Sana , Devi Bijayanti , S. Mrudula 
Published: October 2021

<p class="abstract"><strong>Background:</strong> Palmoplantar dermatoses are skin diseases affecting palms and soles and are commonly seen in the dermatology practice. It can cause significant discomfort to the patients, affecting their daily activities and also is a diagnostic dilemma to the physician. To determine the clinico-epidemiological profile of palmoplantar dermatoses among patients attending the outpatient department (OPD).</p><p class="abstract"><strong>Methods:</strong> Hospital based cross sectional study carried out from September 2018 to August 2020 in patients attending outpatient department of dermatology in Regional Institute of Medical Sciences (RIMS) Hospital, Imphal, Manipur.<strong></strong></p><p class="abstract"><strong>Results:</strong> Of the total 200 patients, nearly half were males (50.5%). Most common age group involved was 26-45 years. Itching was the most common symptom (60%). Multiple lesions with palm alone involvement accounted for higher percentage with 39.5% followed by palmoplantar involvement. Most common palmoplantar dermatosis in the study was eczema with 23% followed by psoriasis (7.5%), dermatophytosis (7%), verruca vulgaris (6.5%), and keratolysis exfoliativa (6%).</p><p class="abstract"><strong>Conclusions:</strong> Eczema was the most common palmoplantar disorder followed by psoriasis. Diagnosis of palmoplantar dermatoses is important at the earliest for appropriate management which helps in improving the patient’s quality of life.</p><p class="abstract"> </p>
Sikap dan Tingkat Kepuasan Petani akan Introduksi Varietas Unggul Baru Padi Gogo
Authors: Chanifah Chanifah , Sahara Dewi , Hartoyo Budi 
Published: October 2021

The development of rice irrigated farming is constrained by the conversion of land agricultural to non-agricultural. Therefore, policy to develop upland rice production in dryland and rainfed lowland is increasingly being implemented. Efforts to expand the application of technological innovations as a lever of upland rice production have intensified by introducing new superior varieties of upland rice. This research aims to analyze farmers' attitudes and satisfaction levels with introducing upland rice to attributes based. The location of this research is in Tegalgiri Village, Nogosari District, Boyolali Regency. Primary data were obtained through a survey method of 35 farmers who planted the Rindang 1, Rindang 2, Inpago 10, and Inpago 12 varieties. Farmer attitudes were analyzed using the Fishbein Multi-attribute Model, while farmer satisfaction level was analyzed using the customer satisfaction index (CSI). The results are the attributes "production" and "resistance to pests and diseases" were agronomic performance which was the most essential and primary consideration for farmers in choosing varieties. Farmers have a positive attitude towards the four new superior varieties. The meaning is that farmers want to adopt and plant the new superior varieties of upland rice. Farmers' satisfaction levels are in the "satisfied" to "very satisfied" category of the four new superior varieties. Hopefully, the new superior upland rice varieties that were introduced can be a choice of varieties by farmers.

Keywords: atributtes, farmer’s attitude, satisfaction level, upland rice, superior varieties
The 16S rRNA Analysis and Enzyme Screening of Bacillus from Rhizosphere Soil of Lombok Island
Authors: Sulistiyani Tri Ratna , Kusmiati Mia , Putri Gita Azizah 
Published: October 2021

Bacillus are commonly found in nature, especially in soil and food. It has the ability to produce bioactive compounds as well as the enzyme. This study was aimed to isolate, identify, and screen their enzyme activities. Four soil samples from Mandalika, Lombok Island, West Nusa Tenggara (NTB), were used for isolation. Bacillus was isolated using the heat-shock method and characterized through Gram staining, endospore staining, and morphological phenotype. Bacillus identification was conducted based on 16S rRNA gene sequence. The hydrolytic enzyme activities were checked qualitatively using selective media, and the enzyme tested including amylase, galactosidase, lipase, protease, and cellulase. As many as twenty-two bacteria isolates were obtained from four soil samples and represented 15 distinct species. The member of bacteria genera successfully identified, consisted of Bacillus sp., Brevibacillus sp., and Fictibacillus sp. Bacillus sp. was the most isolated. Some of the isolated bacteria have the ability to produce lipase, protease, and cellulase that potential to be used in biotechnology processes.

Keywords: Bacillus, hydrolytic enzymes, identification, screening
Value Learning Model: Conception and Implementation (Model Study of Sekolah Perjumpaan Lombok)
Authors: Hamid Abdul , Nashuddin Nashuddin , Wildan Wildan 
Published: October 2021

Character, back to being a public issue lately, has even been disseminated countless amounts of implementation with a fairly high budget spent, as well as educational institutions have designed various attachments, strategies, and methodologies of learning but less successful because it still leaves many moral and ethical issues such as bullying, intolerance, corruption, hoax are increasing. This study aims to determine the empirical relevance of the theoretical conceptualization of the School of Encounters run by community Sekolah Perjumpaan Bangket Bilong and Sekolah Perjumpaan Pagutan Lombok Tengah. This research uses multiple strategies with rationalistic approach and qualitative approach. Data mining with observation techniques, in-depth interviews, and documentation studies. The results of this study show that the concept model Sekolah Perjumpaan (School of Encounter) substantially leads and demands the improvement of human life in the form of improvement of the model of attitudes and behaviors of life, as well as demanding learning based on good and dignified human values. Furthermore, it becomes relevant to the values of character learning that substantively empirically directs humanity to live with the values of the goodness of life continuously. The implications of implementing a value learning model have been able to make significant changes. This can be seen from: the spirit of new life, the awakening of learning motivation, stronger learning relationships, and the growth of caring attitudes of others, both in community life in Bangket Bilong and in the Community of Pagutan Central Lombok.
Failure mode engineered high-energy-absorption metamaterials with biomimetic hierarchical microstructures and artificial grain boundaries
Authors: Gao Zhenyang , Sun Hua , Wang Hongze , Wu Yi , Sun Tengteng , Wang Haowei 
Published: October 2021

Abstract
For numerous engineering applications, there is a high demand for protective lightweight structures with outstanding energy absorption performance and the ability to prevent catastrophic structural failures. In nature, most species have evolved with hierarchical biological structures that possess novel mechanical properties, including ultrahigh specific energy absorption, progressive laminated failure modes, and ability for crack arrestment, in order to defend themselves from hostile environments. In this study, a novel protective metamaterial having spherical hollow structures (SHSs) was developed with different hierarchical microstructures. An artificial failure mode engineering strategy was proposed by tailoring the microstructures of SHS unit cells. To demonstrate the effectiveness of the proposed method, a composite hierarchical SHS lattice structure was developed using a biomimetic laminated failure mode and through a hardening mechanism, mimicking crystal grain boundaries. The quasi-static compressive results indicated a significant improvement in the specific energy absorption, an enhanced plateau stress magnitude, and an obvious delay in the densification stage for the composite hierarchical SHS lattice owing to the constraining effect of its mesoscale grain boundaries and an increased number of intensively engineered laminated failure levels. This novel type of metamaterial was shown to be immensely beneficial in designing lightweight protective aerospace components such as turbine blade lattice infills.
Heterozygous Pathogenic Nonsense ATM Variant Resulting in Unusually High Gastric Cancer Susceptibility
Authors: Guadagnolo Daniele , Mastromoro Gioia , Marchionni Enrica , Germani Aldo , Libi Fabio , Sadeghi Soha , Savio Camilla , Petrucci Simona , Piane Maria , Pizzuti Antonio 
Published: October 2021

Abstract
We describe the unusual presentation of familial early-onset gastric cancer due to a heterozygous pathogenic variant in the ATM gene. The proband had gastric cancer (age 45), and reported a sister deceased for diffuse gastric cancer (age 30) and another sister who developed diffuse gastric cancer (age 52) and ovarian serous cancer. Next Generation Sequencing for cancer susceptibility genes (APC, ATM, BRD1, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, RECQL1, SMAD4, STK11, TP53) identified the truncating c.5944C>T, p.(Gln1982*) variant in ATM (NM_000051.3; NP_000042.3) in the proband. The variant segregated in the living affected sister and in the unaffected daughter of the deceased sister. Heterozygous ATM variants appear to significantly increase the risk for pancreatic, breast, gastric and prostatic cancer and, to a reduced extent, ovarian and colon cancer and melanoma, with moderate penetrance and variable expressivity. Familial gastric cancer is an unusual presentation for ATM. The occurrence of gastric cancer in this family suggests that individual variants may result in different, specific risks. Genotype-phenotype correlations are challenging, given the low penetrance and variable expressivity for ATM variants. Careful family history assessment is pivotal for prevention planning, strengthened by the availability of molecular diagnoses.
Ginsenoside Compound K Inhibits the Proliferation, Migration and Invasion of Eca109 cell via VEGF-A/Pi3k/Akt Pathway
Authors: Huang Jianhou , Pan Dinglong , Liu Feng , Hong Yiting , Huang Gang , Huang Xiaowei , Wang Xinwen , Lin Zhiqiang 
Published: October 2021

Abstract
Objective: Esophageal cancer, one of the most common cancers of the upper digestive tract and is one of the leading cancer-related mortality worldwide. Accumulating studies found that Ginsenoside compound K (CK) has significantly anti-tumor effects, especially in the suppression of proliferation, migration, as well as invasion of various human cancers. While the effects of Ginsenoside CK have not well been studied in esophageal cancer. In our present study, we aim to explore the functions of Ginsenoside CK in the progression of esophageal cancer cells (Eca109).Methods: Cell Counting Kit-8 (CCK-8), wound healing, transwell and flow cytometry assays were applied to analyze the effects of Ginsenoside CK in the progression of Eca109 cell, western bolt was used to investigated the potential downstream signal pathway after Ginsenoside CK treatment.Results: Our study found that Ginsenoside CK can suppressed the cell viability, proliferation, migration and invasion of Eca109 cell. Furthermore, the flow cytometry showed that Ginsenoside CK induced apoptosis rates of Eca109 cell. The western blot results indicated that Ginsenoside CK functions may possibly related to the blockade of the VEGF-A/Pi3k/Akt signaling pathway. Knockdown of VEGF-A gene could suppress poor the progression of Eca109 cells either. Conclusion: In conclusion, our study suggests that Ginsenoside CK inhibited viability, proliferation, migration, invasion, and induced apoptosis of esophageal cancer cells by VEGF-A/Pi3k/Akt signaling pathway.
The Role of Gilts in Transmission Dynamics of Swine Influenza Virus and Impacts of Vaccination Strategies and Quarantine Management
Authors: Ryt-Hansen Pia , Nielsen Henriette Guldberg , Sørensen Simon Smed , Larsen Inge , Kristensen Charlotte Sonne , Larsen Lars Erik 
Published: October 2021

Abstract
Along with an expanding global swine production, the commercial housing and management of swine herds, provide an optimal environment for constant circulation of swine influenza virus (swIAV), thereby challenging farmers and veterinarian in determining optimal control measures. The aim of this study was to investigate the role of gilts in the swIAV transmission dynamics, and to evaluate the impact of different control measures such as quarantine and gilt vaccination. The study was conducted as a cross-sectional study in ten Danish sow herds, including five swIAV vaccinated and five unvaccinated herds. Blood- and nasal swab samples of gilts, first parity sows, and piglets were collected in different stable units of the production system and analyzed for the presence of swIAV and swIAV antibodies. Associations between the detection of swIAV, seroprevalence, antibody levels, quarantine measures and vaccination strategy were thereafter investigated to identify possible risk factors for swIAV introductions and persistence within the herds.Nine of the ten herds had gilts or litters of first parity sows testing positive for swIAV, and swIAV was detected in both the quarantine, mating- and farrowing unit. The seroprevalence were generally higher in the vaccinated herds, but swIAV was still present in nasal swabs from both gilts and piglets in these herds. Notably, the results revealed that having positive gilts in the end of the quarantine increased the risk of having positive one-week-old litters in the farrowing unit by 2.5 times. These results underline that gilts are important contributors to the continuous circulation of swIAV. Additionally, the recorded vaccination schedules along with quarantine and biosecurity measures were far from optimal emphasizing a needed focus on these factors if control of pathogens such as swIAV is desired.
Coronal and Sagittal Balance of Spine in Patients with Developmental Dysplasia of the Hip
Authors: yu yang , song kai , liu jinjin , wu bing , wang zheng , li bo , wang zhaohan , wang yan 
Published: October 2021

Abstract
Objective: To explore the spino-pelvic alignment changes in patients with Developmental dysplasia of the hip (DDH) and the effect of Total hip arthroplasty (THA) on the spino-pelvic alignment.Methods: In this study, patients with DDH are selected as the study group and healthy adults are selected as the control group. The differences of sagittal spino-pelvic parameters between patients with DDH and healthy adults are compared by independent sample t-test. Paired sample t-test is performed for spine-pelvis parameters before and after THA. Pearson correlation analysis is used to analyze the correlation about coronal spine-pelvic parameters. SPSS 22.0 software is used for statistical analysis, and p < 0.05 is the result of statistical significance.Results: In this study, there are 48 patients with DDH in study group, with an average age of 43.1±10.3 years old, consist of 42 females and 6 males. SVA =-4.1±33.9 mm, PI=42.9±18.9°, PT=4.6±15.6°, SS=38.2±13.9°, LL=53.3±12.6°, TK=22.8±9.2°, TLK=6.7±5.7°. There are 214 subjects in control group, SVA=-11.3±28.9mm, PI=45.6±9.4°, PT=9.9±6.8°, SS=35.5±7.1°, LL=48.4±10.8°, TK=27.7±10.4°，TLK=5.7±10°. The differences of SVA, PT, LL and TK were statistically significant. Before THA, IO = 6.7 ± 4.6°, SO = 6.4 ± 5.4°, HO = 5.3 ± 5.8°, L5O = 6.1 ± 5.5°, Cobb angle = 11.0 ± 10.7°; After THA, IO=3.5 ± 3°, SO=3.7 ± 3.4°, HO=3.7 ± 3.6°, L5O= 4.3 ± 4.7°, Cobb angle = 6.8±7.7°. The Cobb angle is related to SO and IO respectively (r=0.610, r=0.570). Conclusions: Due to acetabular dysplasia and dislocation of hip joint, patients with DDH will have changes in sagittal and coronal spino-pelvic alignment. In sagittal plane, PT is decreased, TK is decreased and LL is increased. And THA cannot correct the sagittal spino-pelvic alignment in patients with DDH. In coronal plane, there are Leg length discrepancy (LLD) and hip dislocation in patients with DDH, which together lead to coronal pelvic obliquity (PO). The overall coronal imbalance tendency caused by PO leads to compensatory scoliosis. And THA can significantly improve the degree of PO and compensatory scoliosis in patients with DDH.