bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current management of cancer-associated venous thromboembolism in patients with thrombocytopenia: a retrospective cohort study
Authors: Squizzato Alessandro , Galliazzo Silvia , Rancan Elena , Di Pilla Marina , Micucci Giorgia , Podda Gianmarco , Valeriani Emanuele , Campiotti Leonardo , Bertù Lorenza , Ageno Walter , Porreca Ettore , Lodigiani Corrado 
Published: June 2021

AbstractOptimal management of venous thromboembolism (VTE) in cancer patients with thrombocytopenia is uncertain. We described current management and clinical outcomes of these patients. We retrospectively included a cohort of cancer patients with acute VTE and concomitant mild (platelet count 100,000–150,000/mm3), moderate (50,000–99,000/mm3), or severe thrombocytopenia (< 50,000/mm3). Univariate and multivariate logistic regression analyses explored the association between different therapeutic strategies and thrombocytopenia. The incidence of VTE and bleeding complications was collected at a 3-month follow-up. A total of 194 patients of whom 122 (62.89%) had mild, 51 (26.29%) moderate, and 22 (11.34%) severe thrombocytopenia were involved. At VTE diagnosis, a full therapeutic dose of LMWH was administered in 79.3, 62.8 and 4.6% of patients, respectively. Moderate (OR 0.30; 95% CI 0.12–0.75), severe thrombocytopenia (OR 0.01; 95% CI 0.00–0.08), and the presence of cerebral metastasis (OR 0.06; 95% CI 0.01–0.30) were independently associated with the prescription of subtherapeutic LMWH doses. Symptomatic VTE (OR 4.46; 95% CI 1.85–10.80) and pulmonary embolism (OR 2.76; 95% CI 1.09–6.94) were associated with the prescription of full therapeutic LMWH doses. Three-month incidence of VTE was 3.9% (95% CI 1.3–10.1), 8.5% (95% CI 2.8–21.3), 0% (95% CI 0.0–20.0) in patients with mild, moderate, and severe thrombocytopenia, respectively. The corresponding values for major bleeding and mortality were 1.9% (95% CI 0.3–7.4), 6.4% (95% CI 1.7–18.6), 0% (95% CI 0.0–20.0) and 9.6% (95% CI 5.0–17.4), 48.2% (95% CI 16.1–42.9), 20% (95% CI 6.6–44.3). In the absence of sound evidence, anticoagulation strategy of VTE in cancer patients with thrombocytopenia was tailored on an individual basis, taking into account not only the platelet count but also VTE presentation and the presence of cerebral metastasis.
The Nephroprotective Properties of Extracellular Vesicles in Experimental Models of Chronic Kidney Disease: a Systematic Review
Authors: Nowak Natalia , Yamanouchi Masayuki , Satake Eiichiro 
Published: June 2021

AbstractExtracellular vesicle (EV)-based therapy was hypothesized as a promising regenerative approach which has led to intensive research of EVs in various pathologies. In this study, we performed a comprehensive systematic review of the current experimental evidence regarding the protective properties of EVs in chronic kidney disease (CKD). We evaluated the EV-based experiments, EV characteristics, and effector molecules with their involvement in CKD pathways. Including all animal records with available creatinine or urea data, we performed a stratified univariable meta-analysis to assess the determinants of EV-based therapy effectiveness. We identified 35 interventional studies that assessed nephroprotective role of EVs and catalogued them according to their involvement in CKD mechanism. Systematic assessment of these studies suggested that EVs had consistently improved glomerulosclerosis, interstitial fibrosis, and cell damage, among different CKD models. Moreover, EV-based therapy reduced the progression of renal decline in CKD. The stratified analyses showed that the disease model, administered dose, and time of therapeutic intervention were potential predictors of therapeutic efficacy. Together, EV therapy is a promising approach for CKD progression in experimental studies. Further standardisation of EV-methods, continuous improvement of the study quality, and better understanding of the determinants of EV effectiveness will facilitate preclinical research, and may help development of clinical trials in people with CKD.
Graphical Abstract
Does Impaired Glymphatic Drainage Cause Glymphedema? A Review Tailored to Neurocritical Care and Neurosurgery
Authors: Akins Paul T. , Guppy Kern H. 
Published: June 2021

AbstractResearch into the glymphatic system reached an inflection point with steep trajectory in 2012 when it was formally recognized and named, but the historical roots for it are solid and deep, dating back to pioneers such as Cushing, Weed, and Dandy. We provide an overview of key discoveries of the glymphatic system, which promotes bulk flow of fluid and solutes throughout the brain parenchyma. We also discuss the lymphatic drainage of the central nervous system. Evidence is building that failure of the glymphatic system causes glymphedema in patients commonly managed by neurocritical care and neurosurgery specialists. We review research supporting this for decompressive craniectomy, subarachnoid hemorrhage, and normal-pressure hydrocephalus. We argue that it is time for a paradigm shift from the traditional model of cerebrospinal fluid circulation to a revised model that incorporates the glymphatic pathway and lymphatic clearance. These recent breakthroughs will inspire new therapeutic approaches to recognize, reverse, and restore glymphatic dysfunction and to leverage this pathway to deliver brain-wide therapeutics.
Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease
Authors: Yamamoto Kenji 
Published: June 2021

Abstractα-Synuclein oligomers and Ca2+ dyshomeostasis have been thoroughly investigated with respect to the pathogenesis of Lewy body disease (LBD). In LBD, α-synuclein oligomers exhibit a neuron-specific cytoplasmic distribution. Highly active neurons and neurons with a high Ca2+ burden are prone to damage in LBD. The neuronal vulnerability may be determined by transneuronal axonal transmission of the pathological processes; however, this hypothesis seems inconsistent with pathological findings that neurons anatomically connected to LBD-vulnerable neurons, such as neurons in the ventral tegmentum, are spared in LBD. This review focuses on and discusses the crucial roles played by α-synuclein oligomers and Ca2+ dyshomeostasis in early intraneural pathophysiology in LBD-vulnerable neurons. A challenging view is proposed on the synergy between retrograde transport of α-synuclein and vesicular Ca release, whereby neuronal vulnerability is propagated backward along repeatedly activated signaling pathway.
Termitomenins F and G, Two New Lignan Glucosides from Terminalia chebula var. tomentella (Kurz) C. B. Clarke
Authors: Yin Jun , Zhu Hong-Tao , Zhang Man , Wang Dong , Yang Chong-Ren , Zhang Ying-Jun 
Published: June 2021

AbstractThe extensive chemical investigation on the branches and leaves ofTerminalia chebulavar.tomentella(Combretaceae) led to the isolation of two new lignan glucosides with a furofuran skeleton, termitomenins F (1) and G (2). In addition, 19 known compounds including five lignan glucosides (3–7), six hydrolyzable tannins (8–13) and eight simple phenolics (14–21) were also identified. Their structures were determined by comprehensive spectroscopic analyses. It is noted that8and9wereC-glycosidic hydrolyzable tannins with one hexahydroxydiphenoyl and one gallagyl group linked to an open-chain glucosylC-1/O-2/O-3 andO-4/O-6, respectively, which were rarely found in plants. Nine known compounds,6–9,13, and18–21, were procured from the titled plant for the first time, while3–5,10–12and14–17were also found in the fruits. Notably, the known hydrolyzable tannins8–13exhibited stronger α-glucosidase inhibitory activities with IC50values ranging from 0.10 to 3.12 μM, than the positive control, quercetin (IC50 = 9.38 ± 0.33 μM).Graphic abstract
An update of treatment modalities in children and adolescents with teeth affected by molar incisor hypomineralisation (MIH): a systematic review
Authors: Somani C. , Taylor G. D. , Garot E. , Rouas P. , Lygidakis N. A. , Wong F. S. L. 
Published: June 2021

Abstract
Purpose
To systematically review the treatment modalities for molar-incisor hypomineralisation for children under the age of 18 years. The research question was, ‘What are the treatment options for teeth in children affected by molar incisor hypomineralisation?’

Methods
An electronic search of the following electronic databases was completed MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, LILACS, Google Scholar and Open Grey identifying studies from 1980 to 2020. The PRISMA guidelines were followed. The studies were screened, data extracted and calibration was completed by two independent reviewers.

Results
Of 6220 potential articles, 34 studies were included. Twenty studies investigated management of molars with fissure sealants, glass ionomer cement, polyacid modified resin composite, composite resin, amalgam, preformed metal crowns, laboratory-manufactured crowns and extractions. In four articles management of incisors with microabrasion, resin-infiltration and a combination of approaches was reported. Eight studies looked at strategies to mineralise MIH-affected teeth and/or reduce hypersensitivity. Two studies investigated patient-centred outcomes following treatment. Due to the heterogeneity between the studies, meta-analysis was not performed.

Conclusion
The use of resin-based fissure sealants, preformed metal crowns, direct composite resin restorations and laboratory-made restorations can be recommended for MIH-affected molars. There is insufficient evidence to support specific approaches for the management of affected incisors. Products containing CPP-ACP may be beneficial for MIH-affected teeth.
High order singular value decomposition for plant diversity estimation
Authors: Bernardi Alessandra , Iannacito Martina , Rocchini Duccio 
Published: June 2021

AbstractWe propose a new method to estimate plant diversity with Rényi and Rao indexes through the so called High Order Singular Value Decomposition (HOSVD) of tensors. Starting from NASA multi-spectral images we evaluate diversity and we compare original diversity estimates with those realized via the HOSVD compression methods for big data. Our strategy turns out to be extremely powerful in terms of memory storage and precision of the outcome. The obtained results are so promising that we can support the efficiency of our method in the ecological framework.
License plate identification and recognition in a non-standard environment using neural pattern matching
Authors: Shafi Imran , Hussain Imtiaz , Ahmad Jamil , Kim Pyoung Won , Choi Gyu Sang , Ashraf Imran , Din Sadia 
Published: June 2021

AbstractNon-standard license plates are a part of current traffic trends in Pakistan. Private number plates should be recognized and, monitored for several purposes including security as well as a well-developed traffic system. There is a challenging task for the authorities to recognize and trace the locations for the certain number plate vehicle. In a developing country like Pakistan, it is tough to have higher constraints on the efficiency of any license plate identification and recognition algorithm. Character recognition efficiency should be a route map for the achievement of the desired results within the specified constraints. The main goal of this study is to devise a robust detection and recognition mechanism for non-standard, transitional vehicle license plates generally found in developing countries. Improvement in the character recognition efficiency of drawn and printed plates in different styles and fonts using single using multiple state-of-the-art technologies including machine-learning (ML) models. For the mentioned study, 53-layer deep convolutional neural network (CNN) architecture based on the latest variant of object detection algorithm-You Only Look Once (YOLOv3) is employed. The proposed approach can learn the rich feature representations from the data of diversified license plates. The input image is first pre-processed for quality improvement, followed by dividing it into suitable-sized grid cells to find the correct location of the license plate. For training the CNN, license plate characters are segmented. Lastly, the results are post-processed and the accuracy of the proposed model is determined through standard benchmarks. The proposed method is successfully tested on a large image dataset consisting of eight different types of license plates from different provinces in Pakistan. The proposed system is expected to play an important role in implementing vehicle tracking, payment for parking fees, detection of vehicle over-speed limits, reducing road accidents, and identification of unauthorized vehicles. The outcome shows that the proposed approach achieves a plate detection accuracy of 97.82% and the character recognition accuracy of 96%.
Changes in properties of tar obtained during underground coal gasification process
Authors: Wiatowski Marian , Muzyka Roksana , Kapusta Krzysztof , Chrubasik Maciej 
Published: June 2021

AbstractIn this study, the composition of tars collected during a six-day underground coal gasification (UCG) test at the experimental mine ‘Barbara’ in Poland in 2013 was examined. During the test, tar samples were taken every day from the liquid product separator and analysed by the methods used for testing properties of typical coke oven (coal) tar. The obtained results were compared with each other and with the data for coal tar. As gasification progressed, a decreasing trend in the water content and an increasing trend in the ash content were observed. The tars tested were characterized by large changes in the residue after coking and content of parts insoluble in toluene and by smaller fluctuations in the content of parts insoluble in quinoline. All tested samples were characterized by very high distillation losses, while for samples starting from the third day of gasification, a clear decrease in losses was visible. A chromatographic analysis showed that there were no major differences in composition between the tested tars and that none of the tar had a dominant component such as naphthalene in coal tar. The content of polycyclic aromatic hydrocarbons (PAHs) in UCG tars is several times lower than that in coal tar. No light monoaromatic hydrocarbons (benzene, toluene, ethylbenzene and xylenes—BTEX) were found in the analysed tars, which results from the fact that these compounds, due to their high volatility, did not separate from the process gas in the liquid product separator.
Schilddrüse und Schwangerschaft
Authors: Bojunga Jörg , Hofbauer Ludwig 
Published: June 2021

ZusammenfassungDie Schilddrüsenfunktion spielt eine wichtige Rolle nicht nur in der Entwicklung des Fetus, sondern bereits präkonzeptionell. Eine Kontrolle des TSH-Werts vor Schwangerschaftsbeginn ist insbesondere bei unerfülltem Kinderwunsch sowie bekannter Schilddrüsenhormonsubstitution sinnvoll, um einen möglicherweise bestehenden Substitutionsbedarf zu erkennen und entsprechend auszugleichen. Bei erfolgreicher Konzeption lässt sich ein typischer, trimenonspezifischer Verlauf der Schilddrüsenaktivität beobachten, welcher beeinflusst ist durch schwangerschaftsbedingte Hormonveränderungen. Physiologisch sind ein TSH-Abfall im 1. Trimenon, der selten in eine transiente Gestationshyperthyreose übergehen kann, sowie ein geringgradiger Abfall der fT4-Konzentration im 3. Trimenon. Abzugrenzen von physiologischen Veränderungen der Schilddrüsenhormonkonstellation in der Schwangerschaft sind die eine Behandlung erforderlich machende Hypo- und Hyperthyreose. Sowohl eine Schilddrüsenüber- als auch eine Schilddrüsenunterfunktion hat potenziell schädigende Auswirkungen auf das Ungeborene. Eine therapiebedürftige Hypothyreose in der Schwangerschaft ist mit abhängig vom vorliegenden Antikörperstatus und sollte in Abhängigkeit vom TSH-Wert über die Schwangerschaft hinweg kontrolliert und angepasst werden. Eine weitere besondere Herausforderung besteht bei Notwendigkeit einer thyreostatischen Therapie, beispielsweise im Rahmen eines Morbus Basedow. Hier gilt es, aufgrund der Nebenwirkungsprofile zur Verfügung stehender Thyreostatika trimenonspezifische Medikamentenwechsel zu vollziehen. Der folgende Artikel soll anhand aktueller Daten einen Überblick über aktuelle schilddrüsenbezogene Therapie- und Diagnostikempfehlungen in der Schwangerschaft geben.
Role of Bi3+ ions on structural, optical, photoluminescence and electrical performance of Cd0.9-xZn0.1BixS QDs
Authors: Krishnamoorthy A. , Sakthivel P. , Devadoss I. , Rajathi V. M. Anitha 
Published: June 2021

AbstractIn this work, the Cd0.9-xZn0.1BixS QDs with different compositions of Bi3+ ions (0 ≤ x ≤ 0.05) were synthesized using a facile chemical route. The prepared QDs were characterized for analyzing the structural, morphological, elemental, optical, band gap, photoluminescence and electrochemical properties. XRD results confirmed that the Cd0.9-xZn0.1BixS QDs have a cubic structure. The mean crystallite size was increased from ~ 2 to ~ 5 nm for the increase of Bi3+ ions concentration. The optical transmittance behavior was decreased with increasing Bi3+ ions. The scanning electron microscope images showed that the prepared QDs possessed agglomerated morphology and the EDAX confirmed the presence of doped elements as per stoichiometry ratio. The optical band gap was slightly blue-shifted for initial substitution (Bi3+  = 1%) of Bi3+ ions and red-shifted for further increase of Bi3+ compositions. The optical band gap was ranged between 3.76 and 4.0 eV. High intense red emission was received for Bi3+ (1%) doped Zn:CdS QDs. The red emission peaks were shifted to a higher wavelength side due to the addition of Bi3+ ions. The PL emission on UV-region was raised for Bi3+ (1%) and it was diminished. Further, a violet (422 nm) and blue (460 nm) emission were received for Bi3+ ions doping. The cyclic voltammetry analysis showed that Bi3+ (0%) possessed better electrical properties than other compositions of Bi3+ ions.
Phenotypic and genotypic characterization of mcr-1-positive multidrug-resistant Escherichia coli ST93, ST117, ST156, ST10, and ST744 isolated from poultry in Poland
Authors: Ćwiek Katarzyna , Woźniak-Biel Anna , Karwańska Magdalena , Siedlecka Magdalena , Lammens Christine , Rebelo Ana Rita , Hendriksen Rene S. , Kuczkowski Maciej , Chmielewska-Władyka Monika , Wieliczko Alina 
Published: June 2021

Abstract
Background
A plasmid-mediated mechanism of bacterial resistance to polymyxin is a serious threat to public health worldwide. The present study aimed to determine the occurrence of plasmid-mediated colistin resistance genes and to conduct the molecular characterization of mcr-positive Escherichia coli strains isolated from Polish poultry.

Methods
In this study, 318 E. coli strains were characterized by the prevalence of mcr1–mcr5 genes, antimicrobial susceptibility testing by minimal inhibitory concentration method, the presence of antimicrobial resistance genes was screened by PCR, and the biofilm formation ability was tested using the crystal violet staining method. Genetic relatedness of mcr-1-positive E. coli strains was evaluated by multilocus sequence typing method.

Results
Among the 318 E. coli isolates, 17 (5.35%) harbored the mcr-1 gene. High antimicrobial resistance rates were observed for ampicillin (100%), tetracycline (88.24%), and chloramphenicol (82.35%). All mcr-1-positive E. coli strains were multidrug-resistant, and as many as 88.24% of the isolates contained the blaTEM gene, tetracycline (tetA and tetB), and sulfonamide (sul1, sul2, and sul3) resistance genes. Additionally, 41.18% of multidrug-resistant, mcr-1-positive E. coli isolates were moderate biofilm producers, while the rest of the strains showed weak biofilm production. Nine different sequence types were identified, and the dominant ST was ST93 (29.41%), followed by ST117 (17.65%), ST156 (11.76%), ST 8979 (11.76%), ST744 (5.88%), and ST10 (5.88%). Moreover, the new ST was identified in this study.

Conclusions
Our results showed a low occurrence of mcr-1-positive E. coli strains isolated from Polish poultry; however, all the isolated strains were resistant to multiple antimicrobial agents and were able to form biofilms at low or medium level.
Is Aristotle the Forefather of Informal Logic?
Authors: Groarke Louis F. 
Published: June 2021

AbstractI argue that Aristotle takes a ‘natural language semantics’ approach to logic, which is consistent with the general attitudes one finds in informal logic today. Although his position is complex, Aristotle emphasizes the intensional rather than the extensional side of argument evaluation. He does not take a truth-functional approach to semantics, but an approach that elucidates the illative mechanism through an understanding of natures. This comes close to what informal logicians insist on. The informal logic movement was, to a very large extent, a Canadian initiative, prominently featuring authors such as Johnson, Blair, Govier, and many others.
Prognostic significance of hypoxia-inducible factor-1α expression in advanced pharyngeal cancer without human papillomavirus infection
Authors: Agena S , Hirakawa H , Ikegami T , Kinjyo H , Kise N , Maeda H , Uezato J , Kondo S , Kiyuna A , Yamashita Y , Hasegawa N , Suzuki M , Ganaha A 
Published: June 2021

AbstractObjectiveThis study aimed to clarify the association between both hypoxia-inducible factor-1α and glucose transporter type-1 expression and survival outcome in advanced pharyngeal cancer without human papillomavirus infection.MethodTwenty-five oropharyngeal and 55 hypopharyngeal cancer patients without human papillomavirus infection were enrolled. All patients had stage III–IV lesions and underwent concurrent chemoradiotherapy or surgery. Hypoxia-inducible factor-1α and glucose transporter type-1 expression were investigated in primary lesions by immunohistochemistry.ResultsThere were 41 and 39 cases with low and high hypoxia-inducible factor-1α expression, and 28 and 52 cases with low and high glucose transporter type-1 expression, respectively. There was no significant correlation between hypoxia-inducible factor-1α and glucose transporter type-1 expression. In univariate analysis, nodal metastasis, clinical stage and high hypoxia-inducible factor-1α expression, but not glucose transporter type-1 expression, predicted significantly worse prognosis. In multivariate analysis, hypoxia-inducible factor-1α overexpression was significantly correlated with poor overall survival, disease-specific survival and recurrence-free survival.ConclusionHigh hypoxia-inducible factor-1α expression was an independent risk factor for poor prognosis for advanced human papillomavirus-unrelated pharyngeal cancer.
TNT-KID: Transformer-based neural tagger for keyword identification
Authors: Martinc Matej , Škrlj Blaž , Pollak Senja 
Published: June 2021

AbstractWith growing amounts of available textual data, development of algorithms capable of automatic analysis, categorization, and summarization of these data has become a necessity. In this research, we present a novel algorithm for keyword identification, that is, an extraction of one or multiword phrases representing key aspects of a given document, called Transformer-Based Neural Tagger for Keyword IDentification (TNT-KID). By adapting the transformer architecture for a specific task at hand and leveraging language model pretraining on a domain-specific corpus, the model is capable of overcoming deficiencies of both supervised and unsupervised state-of-the-art approaches to keyword extraction by offering competitive and robust performance on a variety of different datasets while requiring only a fraction of manually labeled data required by the best-performing systems. This study also offers thorough error analysis with valuable insights into the inner workings of the model and an ablation study measuring the influence of specific components of the keyword identification workflow on the overall performance.