bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell‐derived exosome uptake by oral squamous cell carcinoma through macropinocytosis
Authors: Sasabe Eri , Tomomura Ayumi , Liu Hangyu , Sento Shinya , Kitamura Naoya , Yamamoto Tetsuya 
Published: December 2021

AbstractVarious cell types secrete exosomes into their surrounding extracellular space, which consequently affect the function and activity of recipient cells. Numerous studies have showed that tumor cell‐derived exosomes play important roles in tumor growth and progression. Although a variety of endocytic pathways are reportedly involved in the cellular uptake of exosomes, detailed mechanisms remain unknown. The present study demonstrated that treatment with recombinant epidermal growth factor (EGF) time‐ and dose‐dependently promoted cellular uptake of oral squamous cell carcinoma (OSCC) cell‐derived exosomes into OSCC cells themselves. Conversely, EGF receptor (EGFR) knockdown and treatment with EGFR inhibitors, including erlotinib and cetuximab, abrogated OSCC cell uptake of exosomes. The macropinocytosis inhibitor 5‐(N‐ethyl‐N‐isopropyl) amiloride (EIPA) blocked the effects of active EGF/EGFR signaling on uptake of OSCC cell‐derived exosomes. These EGFR inhibitors also suppressed OSCC cell‐derived exosome‐induced proliferation, migration, invasion, stemness, and chemoresistance of OSCC cells. Taken together, the data presented herein suggest that EGFR inhibitors might inhibit the malignant potential of OSCC cells through direct inhibition of not only EGFR downstream signaling pathway but also cellular uptake of OSCC cell‐derived exosomes through macropinocytosis.
‘Teenagers are into perfect‐looking things’: Dating, sexual attitudes and experiences of adolescents with severe obesity
Authors: Walsh Órla , Dettmer Elizabeth , Regina Andrea , Dentakos Stella , Christian Jennifer , Hamilton Jill , Toulany Alene 
Published: December 2021

AbstractBackgroundThis qualitative study explored the dating and sexual health attitudes and behaviours among adolescents with severe obesity (body mass index [BMI] > 99th%) attending a multidisciplinary weight‐management programme.MethodsSemi‐structured interviews were conducted with 19 participants (12 females, 7 males; Mage = 16.8) and analysed through reflective thematic analysis.ResultsParticipants described polarized dating behaviours in which dating and sexual relationships were either avoided due to this not being a priority, lack of time, feared rejection, and/or body size as perceived barrier or in contrast, when approached, involved greater sexual risk.ConclusionsThese findings have numerous implications including the need for increased education on the romantic developmental challenges faced by adolescents with severe obesity, the importance of ongoing screening of high‐risk sexual behaviours and body dissatisfaction from frontline care providers, and the ability to support referrals to psychosocial services when appropriate.
The development of children’s prospective memory: Lessons for developmental science
Authors: Mahy Caitlin E. V. 
Published: December 2021

AbstractThe study of children’s prospective memory has gained new momentum over the past 20 years and is now an active area of research in cognitive development. Yet, this resurgence has been accompanied by significant challenges that offer important lessons and insights for other areas of developmental science. In this article, I provide an overview and theoretical accounts of the development of children’s prospective memory. I then describe three puzzling findings that remain unresolved in children’s development of this kind of memory: (1) the contradictory effects of delay length on prospective memory performance, (2) why reminders sometimes fail to improve prospective memory performance, and (3) why parent reports and behavioral measures of prospective memory might fail to correlate. I discuss how each challenge can be applied broadly to other areas of children’s development. I conclude by highlighting challenges and opportunities as the field moves forward.
Retracted: Adaptive neuro fuzzy inference system to enhance the classification performance in smart irrigation system
Authors: Vivekanandhan VijayaRangan , Sakthivel Subramaniam , Manikandan Muthaiyan 
Published: December 2021

AbstractTraditional agricultural systems require huge amounts of money for on‐site irrigation power. Irrigation is the process of giving water to plants for growth and development. The cost of global warming creates the potential effects of water adaptation measures to ensure food production and water availability for consumption. It requires continuous monitoring of soil moisture content at the root zone and initiating irrigation as per the pre‐programmed schedule depending upon the plant's nature, growth, soil type, and environment. Thus, the cost to farmers using conventional drip irrigation has become so high that they have to go manually and monitor the land frequently. So when the previous method was used for irrigation, it did not give correct classification results. Agricultural data mining technology provides the best crops for travel water to increase the number of crops produced. Agricultural data can be collected more efficiently using data collection and capable analytics sensors. This proposed work introduces an adaptive neuro‐fuzzy inference system (ANFIS) technique for analyzing agricultural plant growth based on soil, water level, temperature, and moisture conditions. The proposed technique has three phases: environment data collection using sensor node, preprocessing, feature selection, and classification. The initial phase captures the plant's environment condition via a sensor device, then transmits data to servers with the help of an edge node or gateway. This recursive adaptive filter method normalizes the data and removes irrelevant noise data from the sensor node. The feature selection method to extract the environment feature value with the help of a linear regression model. The ANFIS method's plant environment feature value has trained the neurons with the help of the stochastic gradient descent method. The classification method introduces a fuzzy rule to compute and validate the input parameters (e.g., soil moisture, temperature, and humidity) to predict any environment value changes. The comparison results prove that efficient monitoring is obtained through the proposed smart irrigation system.
‘Super googs on a Zoom, are you kidding me?’: The pleasures and constraints of digitally‐mediated alcohol and other drug consumption
Authors: Duncan Tristan , Dwyer Robyn , Savic Michael , Pennay Amy , MacLean Sarah 
Published: December 2021

AbstractIntroductionThe COVID‐19 pandemic and associated social restrictions have profoundly shaped the routines, practices and space‐times of alcohol and other drug (AOD) consumption. As a part of these transformations, video conferencing services (e.g. Zoom, Whereby) have emerged as popular mediums for socialising and AOD consumption. In this article, we adopt a more‐than‐human theoretical framework to explore how these online contexts re‐shape experiences of AOD consumption.MethodsData were gathered using a case‐study approach, guided by principles of digital ethnography. We ‘staged’ the online gatherings of three established friendship clusters of adults in Melbourne, Australia, and drew on a discussion guide to elicit accounts of past online AOD encounters during the COVID‐19 pandemic. Our thematic analysis was sensitised to the dynamic composition of these encounters and the kinds of relations, practices and affects they enabled and constrained.ResultsComposed via video conferencing services, AOD consumption afforded distinct pleasures, including enhanced sociality, excitement and momentary reprieves from isolation. Importantly, these effects were not uniform or stable. Participants also navigated various constraints of online AOD consumption while establishing for themselves what substances and associated practices ‘fit’ within these novel encounters.Discussion and ConclusionsOur study conveys the importance of digitally‐mediated AOD consumption as a site of socialising and pleasure. In so doing, it demonstrates the ways in which AOD consumption was drawn on in the everyday negotiation of health and wellbeing under lockdown conditions. We call for research and policy approaches that are sensitive to the affirmative potentials of digitally=mediated AOD encounters.
The Moral Economy of Microfinance in Rural Bangladesh: Dharma, Gender and Social Change
Authors: Maîtrot Mathilde 
Published: December 2021

ABSTRACTMicrofinance is widely portrayed as a tool that empowers poor women to challenge constraining social institutions and make better, rational choices that will enable them to escape poverty. At the same time, the reported impact of microfinance is underwhelming, and scandals and poor practices are widely documented. This then poses a puzzle: why do people still borrow from microfinance institutions? This article seeks to answer that question through an ethnographic examination of the moral economy of microfinance in rural Bangladesh, investigating how morality shapes the remit of legitimate economic activity and social change locally. For men, microfinance fieldworkers use stories of moral ‘idols’ to embed narratives of microfinance within existing rural social institutions as a way to legitimize and normalize microfinance. For women, borrowing is presented as a means to perform dharma — the ‘correct order of things’ — a moral imperative to protect, retain or compete for male guardianship. The moral economy of microfinance is one that motivates people living in poverty to imitate and conform to prevalent gendered and hierarchical norms and values. These arguments highlight the significance of conformity to social and moral obligations in economic behaviour, and bear important implications for understanding the remits of social change.
The Business of Abolition: Marketizing ‘Anti‐slavery’
Authors: McGrath Siobhan , Mieres Fabiola 
Published: December 2021

ABSTRACTThis article conceptualizes contemporary abolitionism as a commodifying cause characterized by multiple processes of marketization. It demonstrates how concerns about the unethical commodification of labour form the basis of a variety of marketization projects and processes. Three processes of marketization in this arena are identified: making relations of advocacy and activism more market‐like; seeking to rehabilitate and/or reform markets in the face of ‘supply chain slavery’; and pursuing abolitionism through commodification. Drawing on project data, and supplemented with empirical observations, interventions to address ‘slavery’, human trafficking and/or forced labour in supply chains are identified and analysed. Marketization is employed as a lens to understand the diverse field of contemporary abolitionism and its relationships to (ideas of) the market. The article highlights how ongoing efforts to reconcile ‘slavery’ and the market posit ethical markets as the solution to the unethical commodification of labour. These efforts are marked by tensions and contradictions, however, necessitating discursive work to position ‘slavery’ as emerging from outside the market.
The development of selective stopping: Qualitative and quantitative changes from childhood to early adulthood
Authors: Albert Jacobo , Rincón‐Pérez Irene , Sánchez‐Carmona Alberto J. , Arroyo‐Lozano Susana , Olmos Ricardo , Hinojosa José A. , Fernández‐Jaén Alberto , López‐Martín Sara 
Published: December 2021

AbstractAlthough progress has been made in elucidating the behavioral and neural development of global stopping across the lifespan, little is known about the development of selective stopping. This more complex form of inhibitory control is required in real‐world situations where ongoing responses must be inhibited to certain stimuli but not others, and can be assessed in laboratory settings using a stimulus selective stopping task. Here we used this task to investigate the qualitative and quantitative developmental changes in selective stopping in a large‐scale cross‐sectional study with three different age groups (children, preadolescents, and young adults). We found that the ability to stop a response selectively to some stimuli (i.e., use a selective strategy) rather than non‐selectively to all presented stimuli (i.e., use a global, non‐selective strategy) is fully mature by early preadolescence, and remains stable afterwards at least until young adulthood. By contrast, the efficiency or speed of stopping (indexed by a shorter stop‐signal reaction time or SSRT) continues to mature throughout adolescence until young adulthood, both for global and selective implementations of stopping. We also provide some preliminary findings regarding which other task variables beyond the strategy and SSRT predicted age group status. Premature responding (an index of “waiting impulsivity”) and post‐ignore slowing (an index of cognitive control) were among the most relevant predictors in discriminating between developmental age groups. Although present results need to be confirmed and extended in longitudinal studies, they provide new insights into the development of a relevant form of inhibitory control.
Comparative feasibility of dobutamine stress echocardiography performed with and without intravenous contrast in patients with class III obesity
Authors: Carlino Carl , Kuppuswamy Saravanan , McCray Lerin , Aggarwal Kul , Alpert Martin A. 
Published: December 2021

AbstractBackgroundConcern exists regarding adequacy of visualization of stress echocardiograms performed without intravenous contrast in persons with Class III obesity (body mass index ≥ 40 kg/m2).MethodsDobutamine stress echocardiography (DSE) was performed on 128 candidates for bariatric surgery with class III obesity without chest pain or pre‐existent coronary artery disease (CAD). DSE without intravenous contrast was initially performed on 62 patients with class III obesity, then was subsequently was performed with intravenous contrast on 66 patients with class III obesity. Left ventricular (LV) regional wall motion was assessed at baseline and peak stress using the 16‐segment model.ResultsIn the intravenous contrast group, 1046 of 1056 LV segments studied (99.1%) were well‐visualized and interpretable at baseline and 1044 of 1056 LV segments studied (98.9%) were well‐visualized and interpretable at peak stress. In the non‐contrast group, 905 of 992 segments studied (91.2%) were well‐visualized and interpretable at baseline and 886 of 992 segments studied (89.3%) were well‐visualized and interpretable at peak stress. A significantly greater number of LV segments were well‐visualized and interpretable in the intravenous contrast group than in the group compared to the non‐contrast group, at baseline and at peak stress (p < 0.00001 for both). DSE was positive for ischemia in one patient. All patients underwent bariatric surgery without cardiovascular complications. Six months after surgery, all patients were alive; none developed cardiovascular events.ConclusionThe use of intravenous contrast during DSE significantly improves visualization and interpretability of LV segments in patients with class III obesity.
English farmers’ wheat storage and sales in the late eighteenth and early nineteenth centuries
Authors: Brunt Liam , Cannon Edmund 
Published: December 2021

AbstractHarnessing previously unused farm inventories and corn books, we provide data on wheat storage and sales by English farmers, 1750–1850. Wheat was predominantly stored outdoors in thatched stacks (or ‘ricks’)—often for more than a year, sometimes for multiple years—although carryover volumes were generally small. Farm stocks tended to be threshed and sold evenly across the year to meet demand. Storage costs were low, and carried over wheat sold at a premium as the natural drying process raised its quality. Wheat was frequently sold directly to millers, bypassing the open market, but private sale prices tracked market prices closely.
Long‐term hydrolytic stability of CAD/CAM composite blocks
Authors: Alamoush Rasha A. , Salim Nesreen A. , Silikas Nick , Satterthwaite Julian D. 
Published: December 2021

AbstractThis study aimed to assess water sorption and solubility of CAD/CAM composite blocks compared to CAD/CAM ceramic after 8 months storage in water and artificial saliva. Eight CAD/CAM blocks were investigated: Five resin‐composite blocks (RCBs), one polymer‐infiltrated ceramic network (PICN) block, one ceramic‐filled polyetheretherketone (PEEK) block, and one feldspathic ceramic block. One hundred and twelve specimens were prepared comprising 14 specimens of each of the eight materials. From each group of specimens, seven randomly selected specimens were immersed in 10 mL of water, while the other seven specimens were immersed in artificial saliva. All specimens were stored at 37°C and weighed at various time intervals. The data were analysed via repeat measures ANOVA, one‐way ANOVA and Tukey's post hoc test (α = 0.05 for all tests). Sorption values (mean [SD]) in water were within the range ‐1.21 (0.4) to 39.3 (2.1) μg/mm3 and in artificial saliva between ‐0.7 (0.2) and 41.6 (1.3) μg/mm3. Solubility values in water were between ‐0.43 (0.08) and 0.34 (0.18) μg/mm3 and in artificial saliva between ‐0.53 (0.07) μg/mm3 and 0.33 (0.2) μg/mm3. CAD/CAM composite blocks were hydrolytically stable under long‐term storage (according to ISO 4949:2009), although not as stable as ceramic. Water sorption of CAD/CAM composite blocks was dependent on the resin‐matrix and was influenced by the filler weight %.
Misconduct risks, legal enforcement and venture capital networks
Authors: Cumming Douglas J. , Mohammadi Ali , Zambelli Simona 
Published: December 2021

AbstractThis study investigates the differing role of enforcement on the formation of venture capital (VC) syndication networks. We conjecture that public enforcement, with strong investigative powers against any syndicate member, discourages the formation of denser syndication networks due to misconduct risk by a member. By contrast, private enforcement, with strong disclosure and liability standards, enables denser syndication networks, through clear liability rules, standardized securities contracts and cost‐sharing amongst syndicate members. Our VC data from 31 countries show a negative impact of public enforcement on VC networks and partially support the positive impact of private enforcement depending on cultural conditions.
Impact of obesity on factor VIII and von Willebrand factor levels in patients with Type 1 von Willebrand disease and low von Willebrand factor: An analysis of the ATHNdataset
Authors: Schaefer Beverly A. , Cheng Dunlei , Kouides Peter 
Published: December 2021

AbstractIntroductionObesity is associated with endothelial dysfunction, haemostatic and fibrinolytic disturbances, however the impact of obesity on von Willebrand factor (VWF) is unclear.AimThe aim of this study was to test our hypothesis that the prevalence of obesity is higher among participants with low VWF (LVWF) compared to type 1 von Willebrand disease (T1VWD).MethodsA retrospective review of the ATHNdataset as of March 2018 was performed. Participants were categorized as T1VWD if their VWF ristocetin cofactor activity was 30 IU/dL and LVWF if the values were 30–50 IU/dL, and by the NIH definitions for body mass index (BMI) for adult participants (≥ 18 years of age) or BMI z‐score for paediatric participants (< 18 years).ResultsThe prevalence of obesity was not significantly different between adults with T1VWD (n = 186) and LVWF (n = 362) (32% vs 36%; p = .345). The mean factor VIII (FVIII) increased with increasing BMIs in both groups. In the paediatric cohort (T1VWD, n = 583; LVWF, n = 1702), there was no difference in the prevalence of obesity, but BMI was positively correlated with mean FVIII (p < .001). Children < 10 years were 27.6% more likely to be diagnosed with T1VWD compared to > 10 years.ConclusionAmong participants in the ATHNdataset, the prevalence of obesity was similar among those with LVWF and T1VWD. However, higher BMI levels were associated with elevated FVIII. Further research is needed to evaluate the impact of obesity on bleeding phenotype and treatment practices.
Circadian rhythmicity on red ear syndrome in a patient with migraine: A case report
Authors: Oliveira Americo Danúzio Pereira , Silva‐Néto Raimundo Pereira 
Published: December 2021

AbstractBackgroundRed ear syndrome (RES) was first described by Lance in 1994. It is characterized by recurrent attacks of redness of the ear, accompanied by burning pain, increased temperature, dysesthesia, and nosological relationship with headache.CaseWe report the case of a 43‐year‐old woman with migraine who developed RES. Redness episodes occurred at the same time of the day. She had a good therapeutic response to gabapentin.ConclusionsTo the best of our knowledge, this is the first case of RES in which redness episodes occurred at the same time of the day.
Improved mechanical properties and toughening mechanism of mullite ceramics reinforced by introducing Ti3AlC2 particles
Authors: Mao Fuzhou , Pi Weiqiang , Li Yuqi , Xu Xu , Wen Ping , Zhou Wei 
Published: December 2021

AbstractTi3AlC2, as a toughening phase, was introduced into mullite ceramics for the first time by the pressureless sintering process aiming at improving the mechanical properties. Significant enhancement in density and mechanical performance of mullite ceramics was achieved through the introduction of Ti3AlC2 particles. The density of as‐prepared mullite–Ti3AlC2 composites was increased by 23% (from 2.86 g/cm3 to 3.51 g/cm3) with Ti3AlC2 increasing from 0 wt% to 20 wt%. The formation of the liquid phase and decomposed particles from Ti3AlC2 are supposed to be responsible for the densification of mullite–Ti3AlC2 composites. The optimal mechanical properties were obtained in the mullite–Ti3AlC2 composites with 15 wt% Ti3AlC2. The bending strength, fracture toughness as well as Vickers hardness were reached 214.36 MPa, 4.84 MPa·m1/2, and 9.21 GPa, which are 40%, 74%, and 113% higher than pure mullite ceramics, respectively. The improved mechanical performance was mainly attributed to the synergetic action of crack deflection, crack branching and bridging, and strengthened grain boundary.
Comparing infrared transmission of zinc sulfide nanostructure ceramic produced via hot pressure and spark plasma sintering methods
Authors: Zahabi Saeed , Jamali Hossein , Bakhshi Saeed Reza , Ashkian Amin , Loghman‐Estarki Mohammadreza 
Published: December 2021

AbstractThis research has investigated the optical properties of zinc sulfide commercial powder sintered via hot pressure (HP) and spark plasma sintering (SPS) methods. SEM images indicated that zinc sulfide commercial powder had spherical morphology, whereby nano rods smaller than 100 nm formed on spherical particles. Investigation of optical properties indicated that the zinc sulfide transparent ceramic prepared via HP (75%) had higher infrared transmission as compared to SPS (69%) within 8–12 micrometer. The stoichiometric ratio of S to Zn in the commercial powder was 1.5, which decreased to 1.1–1.3 after the sintering process.