bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Polyaniline Nanoparticles Crosslinked Hydrogel with Excellent Photothermal Antibacterial and Mechanical Properties for Wound Dressing
Authors: Pang Qian , Wu Kaihao , Jiang Zilian , Shi Zewen , Si Zizhen , Wang Qiang , Cao Yuhao , Hou Ruixia , Zhu Yabin 
Published: December 2021

AbstractAntibacterial hydrogel wound dressing is highly desirable in wound healing and infection control. However, the development of antibacterial hydrogels with controllable antibacterial properties and adequate mechanical properties without bacterial resistance and potential toxicity remains a challenge. Herein, a double bonds‐ended polyaniline nanoparticle (Me‐PANI NP) is synthesized, which can convert light energy into heat upon near‐infrared (NIR) irradiation, and it is used as a novel photothermal antibacterial agent. The obtained bonds‐ended Me‐PANI NPs are subsequently involved in polyacrylamide (PAM) polymerization and served as chemical crosslinking points to form the Me‐PANI NPs@PAM hydrogel, endowing the hydrogel with controllable photothermal antibacterial abilities upon NIR irradiation without time and space limit. Importantly, due to the energy dissipation of Me‐PANI NPs under stretch, the Me‐PANI NPs@PAM hydrogel achieves a maximum stretching ratio of 400% mechanical flexibility. The developed hydrogel can be potentially applied as a novel wound dressing to realize controllable treatment of bacterial infections and accelerate skin wound healing.
Studies on Optical, Structure, and Photoconductivity of Titanium Dioxide Thin Films Prepared by Chemical Bath Deposition Via Aqueous Route
Authors: Kamble Amit A. , Ubale Panchashila A. , Jadhav Amar L. , Jadhav Sharad L. , Kadam Anamika V. , Kanamadi Chidanad M , Bhuse Vijaykumar M. 
Published: December 2021

AbstractTitanium dioxide (TiO2) thin films of different concentrations are prepared by using titanium trichloride on conducting FTO glass substrate by chemical bath deposition (CBD) method. The X‐ray powder diffraction (XRD) method is used to study the structure of TiO2 thin film. XRD analysis has confirmed amorphous nature of the TiO2.The surface morphology of the film is studied using field emission scanning electron microscopy (FE‐SEM). The optical properties are studied using the UV‐VIS and photoluminescence (PL) spectroscopy. The band gap of prepared titanium dioxide (TiO2) thin film is 2.84 eV. A photo‐electrochemical cell analysis shows that the conversion efficiency of 3.24% with a fill factor of 43%.
Structural and Dielectric Properties of PVDF/6A Clay Nanocomposites
Authors: Chanmal Chetan V. , Bandgar Sushil S. , Mungamode Chagan D. , Chavan Sanjeev D. , Pawar Shailesh G. , Mulik Ramesh N. , Mathe Vikas L. , Jog Jyoti P. 
Published: December 2021

AbstractThe paper describes the study of structural and dielectric properties of PVDF blended with organically modified clay. The PVDF/clay nanocomposites are prepared by simple melt mixing method. The prepared nanocomposites are characterized for structural and dielectric properties. The structural characterization done using X‐ray diffraction and infra‐red spectroscopy techniques indicates the crystallization of ferroelectric β phase in nanocomposites. The dielectric study shows the composition‐dependent significant enhancement in the dielectric permittivity, particularly in the low‐frequency region. The enhancement in the dielectric permittivity is explained on the basis of increase in the conductivity and formation of minicapacitor‐like network in the nanocomposites. The dielectric loss spectra of PVDF shows two relaxations corresponding to the glass transition temperature and crystalline relaxation. In case of PVDF/Clay nanocomposites, the dielectric relaxation corresponding to the crystalline relaxation completely disappears, which is attributed to the dielectric manifestation of ferroelectric β phase in nanocomposites. The observed dielectric permittivity data can be very well fitted using Vo‐Shi model, which takes contribution of interphase to the dielectric permittivity. The enhancement in the dielectric permittivity along with ferroelectric β phase in PVDF/clay nanocomposites brings the potential application in energy storage devices.
One‐Pot Synthesis of ZnO Nanorods for LPG Sensing Applications
Authors: Mene Ravindra U. , Shirapure Bhagyashri D. , Narwade Vijaykiran N. , Bogle Kashinath A. , Mahabole Megha P. , Khairnar Rajendra S. , Joshi Ramakant P. , Shelke Pandit N. 
Published: December 2021

AbstractIn the present work, the authors have successfully deposited uniformly upright standing ZnO nanorods on glass substrates by using simple one‐pot chemical bath deposition method. XRD reveals the polycrystalline nature of ZnO thin films. SEM micrograph depicts the well resolved standing growth of ZnO nanorods on glass substrate with an average diameter of 200–300 nm. The optical measurements show that the band gap is 3.3 eV. The detail investigation of LPG sensing study demonstrates the lower operating temperature 190°C with gas response of 105%, with fast response/recovery times 80/70 s, respectively. In addition, the LPG gas uptake capacity remained sensible up to 10 000 ppm.
Polymer‐Metal Oxide Composite (PPy–MoO3) for Ammonia and Ethanol Gas Sensor
Authors: Yenorkar Surendra M. , Zade Ramesh N. , Mude Bhupesh M. , Mayekar Vijay M. , Mude Kushal M. , Raulkar Kishor B. , Mistry Ranjeet R. , Patange A.N. 
Published: December 2021

AbstractPolypyrrole (PPy)–molybdenum trioxide (MoO3) is a polymer‐metal oxide composite (99.9% pure) obtained when two are mixed mechanically with different wt% in acetone medium to obtain different PPy–MoO3 composite materials. The thick films of pure PPy and PPy–MoO3 polymer‐metal oxide composite are prepared by screen printing technique. The prepared mixed composite polymer‐metal oxide materials are calcinated at 800°C for 8 h in air. The thick films are investigated for structural, electrical, and morphological properties. The surface morphology of the thick films is studied by scanning electron microscope (SEM) which shows that the films are granular and porous in nature. The gas responses of pure PPy and PPy–MoO3 polymer‐metal oxide composite thick films are studied for different gases such as ammonia gas (NH3) and ethanol gas at room temperature. The pure PPy thick film shows the poor response to ammonia and ethanol gas, while the thick film 40PPy–60MoO3 gave good responses to ethanol gas (50 ppm) at room temperature. The gas selectivity, sensitivity, stability, gas response, and recovery time of the sensor are measured and presented.
Sol–gel Synthesis, Structural and Dielectric Characteristics of Nanocrystalline Barium Titanate Solid
Authors: Nagdeote Sanjay B. 
Published: December 2021

AbstractNanosized BaTiO3 material is synthesized by sol–gel method. The crystallization temperature of the material is confirmed from TG/ DTA analysis. The Rietveld refined XRD and the FTIR are used to characterize synthesized material. The tetragonal phase with the lattice parameters: a = b = 3.9956Å, c = 4.0266Å and space group P4mm is confirmed. The tetragonality ratio (c/a) is found to be 1.008 which is less than single crystal. The particle size is calculated by using the XRD data and TEM images and it is found to be 70 nm approximately. Dielectric property of sample with temperature and frequency are also studied.
Cobalt Ferrite MNPs: An Efficient and Robust Catalyst for Synthesis of 1,3,5‐Trisubstituted Pyrazolines
Authors: Kukade Mahesh G. , Kagne Raju , Chandane Wilson B. , Bodake Anita J. 
Published: December 2021

AbstractNovel synthesis of 1,3,5‐trisubstituted‐2‐pyrazoline and its derivatives, showing broad spectrum of biological activities in wide range of scientific disciplines is designed via condensation of substituted chalcones and aryl hydrazine in presence of the magnetically separable cobalt ferrite nanoparticles (CoFe2O4 MNPs) to get aimed product with excellent yield in possibly shorter reaction time. Divers structural, morphological, and spectral analytical studies as X‐ray diffraction (XRD), scanning electron microscopy (SEM), and FTIR confirm the formation of CoFe2O4 nanoparticles. The synthesized compounds are characterized and confirmed by spectral analysis. The ambient reaction conditions, ease of purification of the products, and reusability of the catalyst up to five catalytic cycles with almost negligible decrement of catalytic activity making the current protocol benign and promising for its synthetic applications.
Magnetically Retrievable Fe‐doped TiO2 Nanoparticles for Photo‐induced Toxic Dye Removal Applications
Authors: Somwanshi Saurabh B. , Somvanshi Sandeep B. , Kharat Prashant B. , Thorat Nanasaheb D. 
Published: December 2021

AbstractIn light of the applications of nanotechnology in wastewater treatments, an attempt is made to fabricate the Fe‐doped TiO2 nano‐photocatalyst via simple and cost‐effective sol‐gel auto ignition route by following the green synthesis approach. The prepared nano‐photocatalyst samples are characterized by means of X‐ray diffraction (XRD), scanning electron microscopy (SEM), BET, and UV‐Vis spectroscopy in order to study the structural, morphological, surface, and optical properties. XRD analysis validates the anatase phase formation and nanoscale structure of the prepared nano‐photocatalyst. The spherical shaped grain morphology with some agglomeration is visualized in SEM image. The high specific surface area values are observed from the N2‐adsorption/desorption curves of the prepared samples. Further, the photocatalytic performance of the prepared nano‐catalyst samples is evaluated by measuring the percentage degradation of toxic dye (Rhodamine B) under UV light radiation. The degradation rates as 98.7% and 98.2% in 120 min are observed in the case of Rhodamine B for pure and Fe‐doped TiO2 nanoparticles, respectively. The reusability of the prepared nanoparticles is evaluated for five cycles and it shows negligible changes in dye degradation. All these outputs show that prepared Fe‐doped TiO2 nanocatalyst are promising for industrial wastewater purification treatments.
Electrical and Dielectric Studies of the Cd‐Doped Co‐Ni Ferrites Synthesized by Solid State Reaction Method
Authors: Kulkarni Akshay B. , Manohara S. R. , Vishwaroop Rakesh , Mathad Shridhar N. 
Published: December 2021

AbstractThe present study reports the dielectric and DC resistivity studies of the Cd doped Co‐Ni ferrites synthesized by solid state reaction method. The XRD studies confirm the cubic spinel structure of the samples. The substitution of the cadmium in the ferrite system significantly influences the AC conductivity, involvement of the grain boundary involvement in conduction. The variations of dielectric constant and dielectric loss for all the samples are studied as a function of frequency and show an increase with doping concentration. The DC resistivity studies confirm the semiconducting nature of the synthesized ferrites. The activation energy is observed to be in the range of (0.534–0.629 eV).
Synthesis and Characterization of Undoped and Mn‐Doped Copper Oxide Nanoparticles
Authors: Rajasekaran S. , Muthuvel A. , Kannan Karthik , Chinnaiah K. , Maik Vivek , Gohulkumar M. , Gurushankar K. 
Published: December 2021

AbstractCopper oxide (CuO) is a p‐type metal‐oxide semiconductor with a bandgap of 1.2 eV and a minimal bandgap. Solar cells, superconductors, and sensors are among the applications for which it is used. To dope transition metals, researchers use a low‐cost soft chemical process (Mn). The aim of this research is to identify CuO nanopowders using a low‐cost soft chemical method to dope transition metals (Mn). The nanopowders' structural, morphological, functional, and optical properties are investigated. X‐ray diffraction (XRD) analysis findings point to the synthesis of high purity single monoclinic phase CuO nanoparticles. The crystallite size (30 nm) and lattice parameters of Mn‐doped CuO samples are reduced. These results suggest that Mn‐doped CuO nanoparticles may be a promising candidate for optoelectronic devices and photocatalytic organic compound degradation.
Biogenic Synthesis and Characterization of ZnO Nanoparticles from Aloe barbadensis Miller Leaf Extract
Authors: Jangannanavar Vijayakumar D. , Patil Mallikarjun K. , Chougala Lakkanna S. , Inamdar Sanjeev R. , Goudar Kotresh M. 
Published: December 2021

AbstractThis study is aimed to synthesize zinc oxide nanoparticles (ZnO NPs) from Aloe barbadensis Miller leaf extract using the green synthesis method at room temperature. The biosynthesized NPs are characterized by X‐ray diffraction (XRD), UV–vis spectroscopy (UV–vis), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscope (SEM). The XRD pattern has revealed the hexagonal wurtzite structure with a crystallite size of 16 nm for synthesized ZnO NPs. The FTIR results display the formation of ZnO NPs and the presence of other functional groups. The UV–vis absorption spectrum shows an absorption band at 347 nm and the value of the bandgap is found to be 3.75 eV. The surface morphology of synthesized NPs is visualized by SEM images, it is observed that most of the NPs are needle in shape. Further, these NPs will find applications in biosensing and photocatalytic activity.
Development and Fabrication of Carbon Nanotube (CNT)/CuO Nanocomposite for Volatile Organic Compounds (VOCs) Gas Sensor Application
Authors: Onthath Haseena , Maurya Muni Raj , Bykkam Satish , Morsy Hagar , Ibrahim Muna , Ahmed Alaa Elsafi , Riyaz Najam‐US‐Sahar , Abuznad Raghad , Alruwaili Aeshah , Kumar Bijandra , Abdullah Aboubakr M. , Kasak Peter , Sadasivuni Kishor Kumar 
Published: December 2021

AbstractVolatile organic compounds (VOCs) have been recognized as one of the primary trace segments of atmospheric air pollutants. The change in the level of VOCs in the surrounding environment can lead to chronic health issues, respiratory problems, nerve system disorder, and toxicity in kidneys/liver. Thus, monitoring of VOCs concentration in the surrounding environment is significant for avoiding serious health problems. Herein, copper oxide (CuO) nanoparticle and carbon nanotube (CNT) nanocomposite (NC) are presented for the efficient detection of VOCs. The scalable sol‐gel method is adopted for the controlled growth of CNT/CuO NC. The structural, elemental, and morphological analysis is performed by XRD, FTIR spectroscopy, and SEM characterization, respectively. The VOCs sensor was fabricated by drop‐casting the as‐synthesized CNT/CuO NC on interdigitated electrodes (IDEs). The CNT/CuO sensing response is analyzed for six VOCs that include toluene, methanol, acetone, chloroform, xylene, and benzene. The CNT/CuO response towards different VOCs is investigated with respect to change in resistance of the material in the presence of test VOC and in an inert atmosphere. In comparison to other VOCs, the sensor exhibits high sensitivity toward benzene. The estimated change in relative resistance (AR) for benzene is ≈0.62% for 500 ppm concentration. Moreover, the sensor apprehended a detection of benzene with a concentration as low as 5 ppm. The as‐synthesized CNT/CuO NC offers high sensitivity and low detection limit, which benchmark its potential for benzene detection.
Dual Task Turning in Place: A Reliable, Valid, and Responsive Outcome Measure of Freezing of Gait
Authors: D'Cruz Nicholas , Seuthe Jana , De Somer Clara , Hulzinga Femke , Ginis Pieter , Schlenstedt Christian , Nieuwboer Alice 
Published: December 2021

AbstractBackgroundFreezing of gait (FOG) is a complex symptom in Parkinson's disease (PD) that is both elusive to elicit and varied in its presentation. These complexities present a challenge to measuring FOG in a sensitive and reliable way, precluding therapeutic advancement.ObjectiveWe investigated the reliability, validity, and responsiveness of manual video annotations of the turning‐in‐place task and compared it to the sensor‐based FOG ratio.MethodsForty‐five optimally medicated people with PD and FOG performed rapid alternating 360° turns without and with an auditory stroop dual task, thrice over two consecutive days. The tasks were video recorded, and inertial sensors were placed on the lower back and shins. Interrater reliability between three raters, criterion validity with self‐reported FOG, and responsiveness to single‐session split‐belt treadmill (SBT) training were investigated and contrasted with the sensor‐based FOG ratio.ResultsVisual ratings showed excellent agreement between raters for the percentage time frozen (%TF) (ICC [intra‐class correlation coefficient] = 0.99), the median duration of a FOG episode (ICC = 0.90), and the number of FOG episodes (ICC = 0.86). Dual tasking improved the sensitivity and validity of visual FOG ratings resulting in increased FOG detection, criterion validity with self‐reported FOG ratings, and responsiveness to a short SBT intervention. The sensor‐based FOG ratio, on the contrary, showed complex FOG presentation‐contingent relationships with visual and self‐reported FOG ratings and limited responsiveness to SBT training.ConclusionsManual video annotations of FOG during dual task turning in place generate reliable, valid, and sensitive outcomes for investigating therapeutic effects on FOG. © 2021 International Parkinson and Movement Disorder Society
Neutrophil extracellular traps drive epithelial–mesenchymal transition of human colon cancer
Authors: Stehr Antonia M , Wang Guangxia , Demmler Richard , Stemmler Marc P , Krug Julia , Tripal Philipp , Schmid Benjamin , Geppert Carol I , Hartmann Arndt , Muñoz Luis E , Schoen Janina , Völkl Simon , Merkel Susanne , Becker Christoph , Schett Georg , Grützmann Robert , Naschberger Elisabeth , Herrmann Martin , Stürzl Michael 
Published: December 2021

AbstractNeutrophil extracellular traps (NETs) are extracellular structures, composed of nuclear DNA and various proteins released from neutrophils. Evidence is growing that NETs exert manifold functions in infection, immunity and cancer. Recently, NETs have been detected in colorectal cancer (CRC) tissues, but their association with disease progression and putative functional impact on tumourigenesis remained elusive. Using high‐resolution stimulated emission depletion (STED) microscopy, we showed that citrullinated histone H3 (H3cit) is sufficient to specifically detect citrullinated NETs in colon cancer tissues. Among other evidence, this was supported by the close association of H3cit with de‐condensed extracellular DNA, the hallmark of NETs. Extracellular DNA was reliably differentiated from nuclear condensed DNA by staining with an anti‐DNA antibody, providing a novel and valuable tool to detect NETs in formalin‐fixed paraffin‐embedded tissues. Using these markers, the clinical association of NETs was investigated in a cohort of 85 patients with colon cancer. NETs were frequently detected (37/85, 44%) in colon cancer tissue sections and preferentially localised either only in the tumour centre or both in the tumour centre and the invasive front. Of note, citrullinated NETs were significantly associated with high histopathological tumour grades and lymph node metastasis. In vitro, purified NETs induced filopodia formation and cell motility in CRC cell lines. This was associated with increased expression of mesenchymal marker mRNAs (vimentin [VIM], fibronectin [FN1]) and epithelial–mesenchymal transition promoting transcription factors (ZEB1, Slug [SNAI2]), as well as decreased expression of the epithelial markers E‐cadherin (CDH1) and epithelial cell adhesion molecule (EPCAM). These findings indicated that NETs activate an epithelial–mesenchymal transition‐like process in CRC cells and may contribute to the metastatic progression of CRC. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Clinical decision rule for obtaining peripheral blood cultures in febrile oncology patients
Authors: Gorfinkel Lev , Hansen Caitlin E. , Teng Wei , Shabanova Veronika , Prozora Stephanie , Rodwin Rozalyn , Qadri Umar , Manghi Tomas , Emerson Beth , Riera Antonio 
Published: December 2021

AbstractBackgroundThe utility of peripheral blood cultures in pediatric oncology patients presenting with fever is controversial. A recent systematic review showed that about one in 40 bloodstream infections (BSIs) would be missed if only central venous line (CVL) cultures are obtained.ObjectiveTo derive a clinical decision rule for obtaining peripheral blood cultures in pediatric oncology patients presenting to a pediatric emergency department (PED) with fever and a CVL.Design/methodA retrospective chart review was performed on pediatric oncology patients referred to the PED for fever while on therapy. Logistic regression with a random intercept was used to determine independent predictors of BSI and generate a prediction model for obtaining peripheral blood cultures. The decision rule was generated from the best performance as measured by a receiver operator curve. Bootstrapping analysis was performed for internal validation.ResultsPredictors that were significant and independently associated with positive peripheral blood cultures included vasopressor support (odds ratio [OR] 16.5, 95% confidence interval [CI]: 2.80–97.71), acute myeloid leukemia (AML) diagnosis (OR 6.9, 95% CI: 1.81–25.98), hypotension (OR 4.0, 95% CI: 1.05–15.17), mucositis (OR 8.2, 95% CI: 2.48–27.01), and maximum temperature in PED ≥39°C (OR 6.6, 95% CI: 2.36–18.20). The area under the curve (AUC) for this model was 0.90 (95% CI: 0.82–0.97) in the derivation cohort and 0.90 (95% CI: 0.81–0.98) after the internal validation.ConclusionsWe derived a clinical prediction model for deciding when to obtain peripheral blood cultures in febrile oncology patients with CVLs on active therapy. Future studies should focus on prospective and external validation of this diagnostic prediction tool.
Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping
Authors: Loureiro Ana I. , Fernandes‐Lopes Carlos , Bonifácio Maria João , Sousa Filipa , Kiss László E. , Soares‐da‐Silva Patricio 
Published: December 2021

AbstractOpicapone (2,5‐dichloro‐3‐(5‐(3,4‐dihydroxy‐5‐nitrophenyl)‐1,2,4‐oxadiazol‐3‐yl)‐4,6‐dimethylpyridine 1‐oxide) is a selective catechol‐O‐methyltransferase inhibitor that has been granted marketing authorization in Europe, Japan, and United States. The present work describes the metabolism and disposition of opicapone in the rat obtained in support to its development and regulatory filling. Plasma levels and elimination of total radioactivity were determined after oral and intravenous administration of [14C]‐opicapone. The maximum plasma concentrations of opicapone‐related radioactivity were reached at early time points followed by a gradual return to baseline with a biphasic elimination. Fecal excretion was the primary route of elimination of total radioactivity. Quantitative distribution of drug‐related radioactivity demonstrated that opicapone and related metabolites did not distribute to the central nervous system. Opicapone was extensively metabolized in rats resulting in more than 20 phase I and phase II metabolites. Although O‐glucuronidation, ‐sulfation, and ‐methylation of the nitrocatechol moiety were the principal metabolic pathways, small amount of the N‐acetyl derivative was detected, as a result of reduction of the nitro group and subsequent conjugation. Other metabolic transformations included N‐oxide reduction to the pyridine derivative and reductive cleavage of 1,2,4‐oxadiazole ring followed by further conjugative reactions. Reaction phenotyping studies suggested that SULT 1A1*1 and *2 and UGT1A7, UGT1A8, UGT1A9, and UGT1A10 may be involved in opicapone sulfation and glucuronidation, respectively. However, the reductive metabolic pathways mediated by gut microflora cannot be excluded. Opicapone, in the rat, was found to be rapidly absorbed, widely distributed to peripheric tissues, metabolized mainly via conjugative pathways at the nitro catechol ring, and primarily excreted via feces.