bluuebunny/crossref_metadata_2025_split huggingface dataset:
A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates
Authors: Verma N. R. , Naik G. , Patel S. , Padhi P. , Naik T. , Nanda R. 
Published: November 2021

Abstract
Background
Thyroid hormones are essential for fetal growth and the central nervous system development. Thyroid-stimulating hormone (TSH) is the key regulatory hormone. Their levels are quite dynamic in the perinatal period and are influenced by multiple factors. These factors should be taken into consideration during newborn screening. This study aimed to observe the impact of maternal and neonatal factors on neonatal TSH status.

Results
Neonatal TSH (nTSH) depicted a positive correlation with parity (p = 0.066) while negative correlation recorded with maternal blood haemoglobin (p = 0.007) among maternal factors.
New-born length (p = 0.027) and birth weight (p < 0.001) exhibited a negative correlation with nTSH among neonatal factors.

Conclusions
This study concludes that among all the maternal and neonatal factors, birth weight shows the most influence on nTSH. However, the effect may be compounded by other factors. As these risk elements rarely occur singly, it is often difficult to find the exposure which confer the risk on children. These factors should be considered while interpreting the result of the screening program.
Quality of Life in Men With Prostate Cancer Randomly Allocated to Receive Docetaxel or Abiraterone in the STAMPEDE Trial
Authors: Rush Hannah L. , Murphy Laura , Morgans Alicia K. , Clarke Noel W. , Cook Adrian D. , Attard Gerhardt , Macnair Archie , Dearnaley David P. , Parker Christopher C. , Russell J. Martin , Gillessen Silke , Matheson David , Millman Robin , Brawley Christopher D. , Pugh Cheryl , Tanguay Jacob S. , Jones Robert J. , Wagstaff John , Rudman Sarah , O'Sullivan Joe M. , Gale Joanna , Birtle Alison , Protheroe Andrew , Gray Emma , Perna Carla , Tolan Shaun , McPhail Neil , Malik Zaf I. , Vengalil Salil , Fackrell David , Hoskin Peter , Sydes Matthew R. , Chowdhury Simon , Gilbert Duncan C. , Parmar Mahesh K. B. , James Nicholas D. , Langley Ruth E. 
Published: November 2021

PURPOSE Docetaxel and abiraterone acetate plus prednisone or prednisolone (AAP) both improve survival when commenced alongside standard of care (SOC) androgen deprivation therapy in locally advanced or metastatic hormone-sensitive prostate cancer. Thus, patient-reported quality of life (QOL) data may guide treatment choices. METHODS A group of patients within the STAMPEDE trial were contemporaneously enrolled with the possibility of being randomly allocated to receive either docetaxel + SOC or AAP + SOC. A mixed-model assessed QOL in those who had completed at least one QLQ-C30 + PR25 questionnaire. The primary outcome measure was difference in global-QOL (QLQ-C30 Q29&30) between patients allocated to docetaxel + SOC or AAP + SOC over the 2 years after random assignment, with a predefined criterion for clinically meaningful difference of > 4.0 points. Secondary outcome measures included longitudinal comparison of functional domains, pain, and fatigue, plus global-QOL at defined timepoints. RESULTS Five hundred fifteen patients (173 docetaxel + SOC and 342 AAP + SOC) were included. Baseline characteristics, proportion of missing data, and mean baseline global-QOL scores (docetaxel + SOC 77.8 and AAP + SOC 78.0) were similar. Over the 2 years following random assignment, the mean modeled global-QOL score was +3.9 points (95% CI, +0.5 to +7.2; P = .022) higher in patients allocated to AAP + SOC. Global-QOL was higher for patients allocated to AAP + SOC over the first year (+5.7 points, 95% CI, +3.0 to +8.5; P < .001), particularly at 12 (+7.0 points, 95% CI, +3.0 to +11.0; P = .001) and 24 weeks (+8.3 points, 95% CI, +4.0 to +12.6; P < .001). CONCLUSION Patient-reported QOL was superior for patients allocated to receive AAP + SOC, compared with docetaxel + SOC over a 2-year period, narrowly missing the predefined value for clinical significance. Patients receiving AAP + SOC reported clinically meaningful higher global-QOL scores throughout the first year following random assignment.
Reproducibility and Refinement of Urinary LH in the Screening of Progressive Puberty in Girls
Authors: Zung Amnon , Nachmany Aviad , Burundukov Ella , Glaser Tamar , Straussman Sharon 
Published: November 2021

Abstract

Context
First-voided urinary LH (FVU-LH) has been suggested as an alternative to GnRH stimulation test for detection of precocious puberty.

Objective
To evaluate the reproducibility of FVU-LH, its correlation with basal and GnRH-stimulated gonadotropins, and its diagnostic value for differentiating progressive from nonprogressive puberty.

Design and participants
Clinical and endocrine data were obtained from the medical records of 95 girls with suspected progressive puberty who underwent 2 consecutive FVU-LH tests. In 55 of these participants, GnRH stimulation test was performed close to the FVU-LH test. The reported cutoff levels of 5 IU/L and 1.16 IU/L for GnRH-stimulated LH and FVU-LH, respectively, were used as markers of progressive puberty, clinically defined as bone age advancement of ≥1 year and/or growth velocity SD score ≥2, in addition to thelarche.

Results
The 2 consecutive measurements of FVU-LH were highly correlated (r = 0.830; P &lt; 0.001). The higher of the 2 results was better correlated with basal gonadotropins and GnRH-stimulated LH. Furthermore, it aligned better with the clinical outcome of girls with early thelarche, which supports the approach of double tests of FVU-LH to distinguish progressive from nonprogressive puberty. By comparison to GnRH-stimulated LH, the higher FVU-LH value had better sensitivity (68%), whereas peak LH had better specificity (91%) for the diagnosis of progressive puberty. Both tests had high positive predictive value and poor negative predictive value.

Conclusions
The higher value of paired FVU-LH tests can be used to screen girls with suspected progressive puberty and can reduce the need for GnRH stimulation test.
Sex and Liver Disease: The Necessity of an Overarching Theory to Explain the Effect of Sex on Nonreproductive Functions
Authors: Maggi Adriana 
Published: November 2021

Abstract
The number of studies illuminating major sex differences in liver metabolic activities is growing, but we still lack a theory to explain the origin of the functional differences we are identifying. In the animal kingdom, energy metabolism is tightly associated with reproduction; conceivably, the major evolutionary step that occurred about 200 million years ago with placentation determined a significant change in female physiology, as females had to create new energy strategies to allow the growth of the embryo in the womb and the lactation of the newborn. In vertebrates the liver is the metabolic organ most tuned to gonadal functions because the liver synthesizes and transports of all the components necessary for the maturation of the egg upon estrogenic stimulation. Thus, in mammals, evolution must have worked on the already strict gonad-liver relationship fostering these novel reproductive needs. As a consequence, the functions of mammalian liver in females diverged from that in males to acquire the flexibility necessary to tailor metabolism according to reproductive status and to ensure the parsimonious exploitation and storage of energy for the continuation of gestation in case of food scarcity. Indeed, several studies show that male and female livers adopt very different strategies when confronted with nutritional stress of varied origins. Considering the role of liver and energy metabolism in most pathologies, a better focus on liver functions in the 2 sexes might be of considerable help in personalizing medicine and pharmacology for male and female needs.
Disaster Theory
Authors: Lindsay Stuart 
Published: November 2021

AbstractThe online community of vaporwave music is a cultural development that emerged in the 2010s and therefore fully within the ideological sphere of postindustrialism. Consisting of slowed-down samples from pop songs and advertising jingles from the 1980s and 1990s stitched together with original synthesizer pieces that resemble those used in horror-film scores, vaporwave is an undead, artificial soundscape that floats somewhere between music and sound. Its fake nostalgia for an alternative yet ossified past aims to confront our contemporary social paralysis in the face of postmillennial economic failure and political crisis. This article examines gothic elements of the vaporwave music phenomenon to analyze how vaporwave expresses sociopolitical traumas of late capitalism. Derridean notions of hauntology articulate the individual’s self-isolation and objectification under the neoliberal homogenization of culture in vaporwave artist Begotten’s contributions to the hushwave subgenre of the scene (2018–19). Vaporwave’s cyclical and uncanny sounds embody the spectral haunting of Marx in capitalism’s repetitive pronunciation of victory over its vanquished, communist foe in Sunsetcorp’s 2009 single “nobody here” and the manifestations of American political trauma after 9/11 in Cat System Corporation’s signalwave album, News at 11 (2016).
Manipulation of Precise Molecular Arrangements and Their Photochemical Properties on Inorganic Surfaces via Multiple Electrostatic Interactions
Authors: Ishida Yohei 
Published: November 2021

Abstract
Multiple (or multivalent) interaction is the key in many biological systems. One of the most important (photo-)chemical reactions, photosynthesis, is driven by regularly aligned molecules by multiple interactions between proteins and molecules. A grand challenge of modern chemistry therefore includes the construction of supramolecular assemblies and control of their functions for mimicking nature and beyond. While most synthetic systems depend on covalent, coordination and hydrogen bonds between molecules, my approach focuses on multiple electrostatic interactions with two-dimensional clay mineral nanosheets. I here summarize my recent work on manipulation of precise molecular arrangements and photochemical properties via multiple electrostatic interactions. This Account mainly consists of the three parts; 1: manipulation of photochemical properties of molecules and new emission enhancement phenomenon (chapters 2–7), 2: efficient photochemical reactions and artificial photosynthesis model (chapters 8–14), and 3: molecular-scale understanding by means of electron microscopy (chapters 15–17).
Assessing the generalisability of a multicentre qualitative dementia research: the experience and challenges faced by the MinD project in Europe
Authors: Lim Jennifer N.W. , Niedderer Kristina , Tournier Isabelle , Almeida Rosa , Harrison Dew , Holthoff-Detto Vjera , Ludden Geke , van Rompay Thomas , van der Voort Mascha , Galansinska Aleksandra , Smith Tina , Lasada Raquel L. , Bueno Yolanda A. , Druschke Diana , Ziebuhr Berit , Zanasi Michele 
Published: November 2021

Background: Generalisation of findings is an important aspect of research and essential for evidence-based practice. While generalisation is common in quantitative research, there is a lack of generalisability in qualitative research. This paper presents the experience and challenges faced by the Designing for People with Dementia (MinD) project in meeting the requirements to strengthen the generalisation of findings on the lived experience of people living with dementia and their engagement to co-create designs to empower their everyday living. Methods: Polit and Beck (2010)’s strategies to generalise qualitative findings were applied: (1) replication in sampling; (2) replication of studies; (3) meta-synthesis of findings; (4) reflexivity and conceptualization; (5) immersion with the data; and (6) thick description. Results: While it is possible to increase the generabilisabilty of qualitative evidence through the replication of the sampling to attain a large, heterogeneous sample in different and multiple contexts and environments; implementation of sound and robust research; conducting in-depth analysis and interpretation collaboratively for emergent themes; and meeting the thick description requirement, there are challenges that the project team faced in implementing some of the Polit and Beck’s strategies because of the condition, namely dementia, that our participants are having. Other challenges faced were: the language and cultural diversity in the team; diverse work and organisational procedures; and the inter-disciplinary differences relating to the methods of enquiry, approaches and techniques to conduct research. These challenges will need to be identified and addressed at the start of the project with a strong leadership to ensure a seamless journey to complete the project successfully. Trust between the researchers and participants, and time to build this trust are critical to recruitment and participation in the study; these factors are of utmost important in research involving participants with condition such as dementia.
Dual-parameter sensing of refractive index and pressure by dual-polarization microresonators
Authors: Zhang Ping , Yan Zhiruo , Zhang Chen 
Published: November 2021

We propose a dual-polarization microring resonator that can simultaneously measure refractive index and pressure. Since the transverse electric (TE) mode and the transverse magnetic (TM) mode of a silicon waveguide have different energy distributions, TE and TM polarization have significant differences in sensitivity to environmental refractive index and pressure changes. Different responses to external refractive index and pressure changes can be obtained by simultaneously exciting TE and TM modes in a microring resonator. The refractive index sensitivities obtained in the experiment were 132.97 and 40.54 nm/RIU; the pressure sensitivities were 1.41 and 1.59 pm/KPa, respectively. By inversion of the second-order sensitivity matrix, it is verified that the effective refractive index and pressure response can be obtained simultaneously through a single measurement to realize the dual-parameter sensing of the surrounding refractive index and the pressure of the device structure.
Preschool aged child’s literacy experience through everyday play in the home: A creative pathway to early literacy learning.
Authors: Ojo Nanbam Y. , Ekanem Inibehe E. 
Published: November 2021

Two major events have brought research on preschool aged children to the centre of educational research in Nigeria. First, Nigeria is a signatory to the United Nations Convention, which is leading a campaign for the adoption and ratification of the Rights of the child. Secondly, the introduction of early childhood education in tertiary teacher training programmes has pointed to the need for quality research in the diverse fields of early childhood studies. One area that is yet to receive enough research attention relates to doing early literacy research in the home, in particular, with preschool aged children in the context of play. Using the empirical context of a six-week study of a 4-year-old preschool child in her home in Jos Plateau State, this paper studies how the child’s engagement in play enriched her early literacy learning. The study adopts participant observation and interview methods to collect data from multiple sources in the child’s home. Theoretically, the study is framed on an eco-cultural approach on child-initiated play and learning with accessible literacy resources. The theoretical framework enabled the identification of the learning opportunities in the home and the child’s capacity to act independently. It was also useful for studying the parents’ ethnotheories and support for learning in the home. Using thematic analysis, the findings indicate the child was critically engaged with hybrid traditions of literacy- texts and representations. The paper has implications for policy on partnering with parents for children’s literacy development.
Apoyo a los subsistemas de talento humano, selección y reclutamiento a partir de un sistema experto. Caso de estudio
Authors: Matute-Pinos Karina , Bojorque-Chasi Rodolfo 
Published: November 2021

La gestión de talento humano es un factor fundamental en el éxito de las organizaciones. La inclusión en el entorno laboral de las personas con discapacidad ha ayudado a potenciar sus cualidades y a aprovechar su talento. Muchos de los sistemas de gestión de talento humano carecen de directrices para el reclutamiento y selección de una persona con discapacidad, es por eso por lo que el presente trabajo muestra el estudio realizado a estos dos procesos indicando los factores que influyen en la asignación o no de un cargo, donde de cada candidato es considerando el nivel y tipo de discapacidad, nivel de estudios, experiencia, capacitación entre otros aspectos, enfocándose en la tarea de aplicar técnicas de aprendizaje supervisado que permitan clasificar a un candidato con discapacidad para un puesto de trabajo como apto o no y técnicas de aprendizaje no supervisado como el clustering que ayuda a definir patrones ocultos en los datos si los hubiera. El resultado obtenido del estudio presenta varias técnicas de clasificación y la selección de la más adecuada para el conjunto de datos en cuestión, igualmente mediante técnicas de aprendizaje no supervisado se determina cuántos clústeres representativos se identifican en los datos. No se busca que se integren las personas a través de las discapacidades, sino todo lo contrario, que se integren las personas por medio de la potencialidad de todas sus capacidades.
ПРЕИМУЩЕСТВА ИСПОЛЬЗОВАНИЯ ЦИФРОВЫХ ТЕХНОЛОГИЙ ПРИ РЕГИСТРАЦИИ ОБЪЕКТОВ АВТОРСКОГО ПРАВА
Authors: Садыкова Джыпаргуль Джалиловна 
Published: November 2021

В статье рассмотрены вопросы регистрации объектов авторского права в Кыргызской Республике и использования цифровых технологий при регистрации произведений.
The	Role of Simulated Patient in Physiotherapy Education: A Review Article
Authors: Javaherian Mohammad , Dabbaghipour Narges , Khabaz Mafinejad Mahboobeh , Ghotbi Nastaran , Khakneshin Amir Ali , Attarbashi Moghadam Behrouz 
Published: November 2021

Introduction: Using Simulated Patients (SPs) in clinical skills education is a common method of training students to improve their skills for future client encounters. This systematic review aims to provide an overview of the SP strategy in Physical Therapy (PT) education.
Materials and Methods: PubMed, Scopus, and Web of Science databases were searched from January 1980 up to November 2019. Different keywords related to the topic were selected using MeSH. Any types of quantitative study design which had used simulation-based learning in physical therapy were eligible for inclusion. Two reviewers read studies and appraised them critically.
Results: A total of 1049 abstracts were retrieved and after reviewing the full-text paper, 11 full- text articles met the inclusion criteria. These studies had used simulated patients for various objectives, including replicate different aspects of knowledge, self-perceived skills, real clinical practice, attitudes, and feasibility. Based on the result of studies, SP as an educational technique can improve student’s clinical reasoning skills, communication, and motivation in a safe environment.
Conclusion: SP is a useful learning strategy to deliver learning activities in medical education and physical therapy curricula, facilitating feedback on students’ performance with opportunities to interact with real patients and environments.
The Effects of Estrogen and Progesterone Hormones on Active Hip Joint Position Sense in Healthy Women in Different Phases of a Menstrual Cycle
Authors: Mosavi Ghomi Maliheh , Shariati Mehrdad , Mokhtari Mokhtar , Ramezani Nowrozani Fatemeh 
Published: November 2021

Introduction: The proprioceptive system is a sensory system based on an individual’s knowledge of his or her body. This knowledge is transmitted to the brain through inputs received from joints, muscles, tendons, and ligaments. As a result, these inputs inadvertently inform the brain of the state of the body’s muscles. Numerous factors can affect this system. This study aimed to investigate the effect of estrogen and progesterone hormones on understanding and recognizing the proprioceptive sense of hip joint in healthy women during the menstrual cycle.
Materials and Methods: In this quasi-experimental study, 15 healthy women participated voluntarily. They had regular menstrual cycles without any history of disease and drug use. The concentration of estrogen and progesterone during a cycle in the follicular (4-6 days), ovulation, and luteal phases were evaluated to detect their effects on the sense of perception and cognition of the proprioceptive joint in the two movements of abduction and flexion by the target angle reconstruction method (30°).
Results: The errors of active joint position sense were reduced in abduction and flexion during ovular and luteal phases compared to the follicular phase. However, in the flexion direction of hip movement, there was a significant difference in absolute error during hormonal changes in the menstrual cycle (P=0.000).
Conclusion: The results showed that due to more involvement of motor control of hip muscles joint by motor neuron activity (increase release of estrogen hormone), all errors reduced in ovular and luteal phases compared to the follicular phase. The flexion movement is more disturbed, and due to more flexibility in this direction, absolute errors are significantly reduced. This reduction of errors in ovular and luteal phases compared to the regular stage of hormone release (follicular phase) may cause some rigidity in the hip joint and an increase of trauma in external mechanical forces. This study’s findings showed that the lowest proprioception sensation is in the follicular phase. Decreasing the concentration of sex hormones in this phase is likely to reduce the sense of recognition of the joint, thus increasing the likelihood of injury in this phase. Findings from this study showed that the lowest proprioceptic sensation is in the follicular phase. The results of this study showed that the least sense is Prvpryvsptyk in Fazfvlykvlar.
Depression Associated With COVID-19 and its Impact on Physical Activities of Young Adults of Pakistan
Authors: Samejo Bakhtawar , Bibi Noonari Sajida , Munir Memon Sikander , Noor Dua-e- 
Published: November 2021

Introduction: Coronavirus Disease 2019 (COVID-19) is a cluster of acute respiratory illnesses with unknown etiology, which firstly appeared in Wuhan, Hubei Province, China, in December 2019. All educational institutes of Pakistan were completely closed from March 13, 2020, to August 15, 2020. This condition disturbs the daily routines of children with mental health needs. This sudden closure limited their physical activities in their routine life. This study aims to observe the depression associated with COVID-19 and its impact on the physical activities of young adults of Pakistan.
Materials and Methods: A web-based cross-sectional study was conducted on 384 young adults. A modified depression scale was used to assess depression, and the revised physical activity questionnaire was used to evaluate the physical activity of Pakistani young adults in the past month.
Results: About 57.8% of the samples were sometimes sad; 44.5% sometimes felt grouchy in the mood; 43.8% never felt hopeless about the future. Also, 32.6% sometimes slept less or more than usual, 35.9% sometimes had difficulty concentrating on their work, 48.7% slept 6-8 hours per day. Besides, 49% engaged 1-3 hours in work or study per day; 43.2% watched TV, sat quietly, or listened to music for 1-3 hours. About 57.8% engaged less than 1 hour per week in light physical activities. Also, 77.9% engaged for less than 1 hour per week in moderately strenuous activities.
Conclusion: Depression could be highly associated with the COVID-19 outbreak, and it might affect the physical activities of young adults.