bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review and meta‐analysis of variants of the branches of the superior mesenteric artery: the Achilles heel of right hemicolectomy with complete mesocolic excision?
Authors: Cirocchi Roberto , Randolph Justus , Davies R Justin , Cheruiyot Isaac , Gioia Sara , Henry Brandon Michael , Carlini Luigi , Donini Annibale , Anania Gabriele 
Published: August 2021

AbstractAimDissection with subsequent ligation and resection of arteries at their origin (central vascular ligation) is essential for adequate oncological resection during right hemicolectomy with complete mesocolic excision. This technique is technically demanding due to the highly variable arterial pattern of the right colon. Therefore, this study aims to provide a comprehensive evidence‐based assessment of the arterial vascular anatomy of the right colon.MethodsA thorough systematic literature search through September 2020 was conducted on the electronic databases PubMed, Scopus and Web of Science to identify studies eligible for inclusion. Data were extracted and pooled into a meta‐analysis using MetaXl software.ResultsA total of 41 studies (n = 4691 patients) were included. The ileocolic artery (ICA), right colic artery (RCA) and middle colic artery (MCA) were present in 99.7% (95% CI 99.4%–99.8%), 72.6% (95% CI 61.3%–82.5%) and 96.9% (95% CI 94.2%–98.8%) respectively of patients. Supernumerary RCA and MCA were observed in 3.2% and 11.4% respectively of all cases. The RCA shared a common trunk with the ICA and MCA in 13.2% and 17.7% respectively of patients. A retro‐superior mesenteric vein course of the ICA and RCA was observed in 55.1% and 11.4% respectively of all cases.ConclusionThe vascular anatomy of the right colon displays several notable variations, namely the absence of some branches (RCA absent in 27.4% of cases), supernumerary branches, common trunks, and retro‐superior mesenteric vein courses. These variations should be taken into consideration during right hemicolectomy with complete mesocolic excision to ensure adequate oncological resection while minimizing intra‐operative complications.
Using passive surveillance technology for overdose prevention: Key ethical and implementation issues
Authors: van Draanen Jenna , Satti Sampath , Morgan Jeffrey , Gaudette Laural , Knight Rod , Ti Lianping 
Published: August 2021

AbstractPassive surveillance technology has the potential to increase safety through monitoring spaces where people are at risk of overdose. One key opportunity for the use of passive surveillance technology to prevent overdose fatality is in bathrooms where people may be using drugs. However, uncertainty remains with regards to how to attain informed consent, implications for data storage and privacy and potential negative socio‐legal ramifications for people who use drugs. In addition, there are issues regarding responsibility and liability for the devices. Transparency with regards to data privacy and security may also be needed before bathroom users will feel comfortable with such solutions. In this article, we discuss these issues and offer recommendations to provide a foundation for future research and policy development.
Retirement and health services utilization in a low‐income country*
Authors: Dang Thang 
Published: August 2021

AbstractWe estimate the causal effects of retirement on health services utilization in Vietnam. Using authorized retirement ages as instruments for exogenous changes in retirement, we find positive and strong effects of retirement on outpatient health services in the public health sector. Retirement increases the probability of an outpatient visit by 51 percentage points for males and 36 percentage points for females, and the frequency of outpatient visits by 1.4 times for males and 2 times for females. However, we find no effect on the use of public inpatient services as well as private health services.
Effects of different indices and pairwise methods on the longitudinal pattern of β diversity of stream fish assemblages
Authors: Zhang Dong , Gao Rundong , He Jiayun , Chu Ling , Yan Yunzhi 
Published: August 2021

AbstractBeta diversity is the key and central issue of theoretical and applied ecological questions, including those regarding spatial variation along gradients and conservation biodiversity. In contrast to the alpha diversity of stream fish assemblages, little concern has been reached regarding the factor affecting of spatial variation in beta diversity along longitudinal gradients, which may be modified by scale, indices of beta diversity and pairwise methods. To understand the spatial patterns and processes in the species composition of stream fish assemblages along the river continuum, we need to disentangle the influence of different beta diversity indices and pairwise methods on the longitudinal patterns of beta diversity. In this study, we chose four beta diversity indices (Jaccard, Sørensen, Simpson and additive partitioning) and two pairwise methods (mean beta diversity between the focal assemblage and all other assemblages; beta diversity between focal and immediate neighbouring assemblages downstream) to quantify the spatial pattern of fish beta diversity along the river continuum. We found that (1) although the four diversity indices differed in emphasis, they showed the same pattern of spatial variation in the longitudinal gradients of the river; (2) the same diversity index using different pairwise methods calculation may result in completely different spatial patterns; (3) beta diversity indices and pairwise may not have a significant effect on the ecological application of beta diversity, at least in community assembly. In conclusion, the results of our study suggest that at least in the longitudinal gradient of the river there may not be much difference in quantifying the spatial variation of beta diversity; however, pairwise methods between sampling sites need to be chosen according to specific research objectives.
Assessment of putative species diversity of insect larvae occurring in bamboo galls by a DNA barcoding analysis
Authors: Nomano Fumiaki Y. , Mitsui Hideyuki , Kimura Masahito T. 
Published: August 2021

AbstractFor identification of insect larvae occurring in galls formed on culms of Sasa kurilensis in Shiga‐kôgen, Nagano and those of Pseudosasa japonica in Takao‐san, Tokyo, we undertook a DNA barcoding analysis using the mitochondrial cytochrome oxidase subunit 1 (CO1) gene. Seventeen operational taxonomic units (OTUs) were identified for larvae from Shiga‐kôgen and one for those from Takao‐san. Of 17 OTUs from Shiga‐kôgen, 10 were most likely assigned to Cecidomyiidae (Diptera), one to Anthomyzidae (Diptera), two to Lepidoptera and four to Hymenoptera. One OTU from Takao‐san was assigned in the Cecidomyiidae cluster. However, none of the OTUs was assigned to known species. It is unknown whether primary gall‐makers are included in the putative cecidomyiid, anthomyzid and lepidopteran species found in this study. However, hymenopteran species occurring in these galls would be parasitoids. How so many cecidomyiid species coexist on bamboo culms in Shiga‐kôgen is an interesting issue and remains to be resolved.
Keeping your coparent in mind: A longitudinal investigation of mindfulness in the family system
Authors: DiMarzio Karissa , Peisch Virginia , Acosta Juliana , Dale Chelsea , Gutierrez Jennifer , Parent Justin 
Published: August 2021

AbstractRecent studies have increasingly focused on mindfulness as it relates to interpersonal processes. In particular, cross‐sectional research has shown that parents’ dispositional mindfulness is associated with increased mindful parenting and coparenting, as well as improved coparenting relationship quality. The current study replicates and extends such work, representing the first longitudinal investigation of mindful coparenting. A sample of 449 parents (60% mothers) of children between the ages of 3 and 17 years were recruited online through Amazon‘s Mechanical Turk (MTurk) as part of a larger study on the assessment of parenting. Parents reported on their dispositional mindfulness, mindful coparenting, and coparenting relationship quality at three time points across an 8‐month period. Results from a cross‐lagged panel model using maximum likelihood estimation suggested that higher levels of parental mindfulness at baseline were related with higher levels of mindful coparenting at 4 months, which, in turn, were related to higher quality coparenting relationship at 8 months. Support for this model was found for both mothers and fathers and across all examined child age groups (i.e., early childhood, middle childhood, and adolescence), highlighting the robust nature of these effects. Overall, findings suggest that increasing mindfulness at an individual level can promote meaningful change within a family system, specifically through improvements in coparenting and parent–child interactions.
The role of SIRT1 in the basolateral amygdala in depression‐like behaviors in mice
Authors: Guo Hao , Deji Cuola , Peng Han , Zhang Jinyu , Chen Yuanyuan , Zhang Yulei , Wang Yunpeng 
Published: August 2021

AbstractPrevious investigations have implicated the basolateral amygdala (BLA) epigenetic mechanisms in the pathophysiology of depression. SIRT1 is a NAD+‐dependent class III histone deacetylase, widely expresses in BLA. However, epigenetic mechanisms in the BLA under the regulation of SIRT1 in the depression are largely uncharacterized. Under the chronic unpredictable chronic mild stress (CUMS) mouse model, we used adeno‐associated viral vectors (AAV) that encoded SIRT1‐shRNA or SIRT1 to specifically knockdown or overexpress SIRT1 in BLA neurons, respectively. CUMS procedure induced significant depression symptoms including the decreased sucrose preference, the less bodyweight gained, the decreased immobile latency and the increased immobile time both in forced swim test (FST) and tail suspension test (TST). Knockdown of SIRT1 in BLA glutamatergic neurons reversed these depression‐like behaviors and restored the synaptic abnormalities. Overexpression of SIRT1 in BLA glutamatergic neurons induced depression‐like behaviors in non‐stressed control mice. The result of protein expressions and ultrastructural changes were consistent with the behavioral results. Our study suggested that downregulation of SIRT1 in BLA has certain beneficial effect on CUMS‐induced depression‐like behaviors such as anorexia, anhedonia, hopelessness and despair. In addition, the increased expression of SIRT1 may be the immediate cause of depressive‐like symptoms. The abnormal expression of SIRT1 may affect the transcriptional regulation mechanism and signaling protein acetylation, affecting neuroplasticity and ultimately contribute to MDD. In the stress‐susceptible mice, these two mechanisms may co‐exist, but the specific mechanism needs further research.
Effect of dentures on pharyngeal swallowing function in patients with dysphagia
Authors: Takagi Daisuke , Ohno Tomohisa , Moriwaki Motoki , Katagiri Norimasa , Umeda Yoshiko , Tohara Haruka , Nomoto Akiko , Fujishima Ichiro 
Published: August 2021

AimDentures play an important role in improving masticatory and oropharyngeal swallowing functions in some edentulous patients without dysphagia. However, few studies have been conducted on patients with dysphagia. This study investigated the effect of dentures on pharyngeal swallowing function in patients with dysphagia.MethodsOlder inpatients with dysphagia who used well‐fitting dentures were included in the study. Videofluoroscopic swallowing study findings with and without dentures were compared. Pharyngeal residue and area as spatial, the distance between the maxilla and mandible, hyoid bone/laryngeal displacement, and upper esophageal sphincter opening as kinematics, oral/pharyngeal transit time as temporal measurements, and patient‐reported symptoms were evaluated. The primary outcome was the pharyngeal residue measured using the normalized residue ratio scale. Comparisons were made using the paired t‐test, Wilcoxon signed‐rank test and Fisher's exact test.ResultsThe mean age of the 27 participants was 86.1 ± 6.8 years. The vallecular residue was more in those without dentures (with dentures: 0.01 [0–0.02], without dentures: 0.03 [0–0.08]; P = 0.003). The pyriform sinus residue showed no significant difference. Denture removal significantly increased the pharyngeal area. The distance between the maxilla and mandible decreased in the absence of dentures, and other kinematic measurements showed no significant differences. Oral/pharyngeal transit time was prolonged without dentures.ConclusionsMorphological changes caused by the removal of dentures led to pharyngeal expansion, which may result in increased vallecular residue. A treatment plan that considers the effect of dentures on pharyngeal swallowing function may provide rehabilitation that is more effective. Geriatr Gerontol Int 2021; 21: 907–912.
Calcium hydroxide‐loaded PLGA biodegradable nanoparticles as an intracanal medicament
Authors: Elmsmari Firas , González Sánchez José Antonio , Duran‐Sindreu Fernando , Belkadi Roumaissa , Espina Marta , García Maria Luisa , Sánchez‐López Elena 
Published: August 2021

AbstractAimTo develop a formulation in which calcium hydroxide (Ca(OH)₂) was successfully loaded into poly(lactic‐co‐glycolic acid) (PLGA) biodegradable nanoparticles (NPs) to be used in the field of endodontics as an intracanal medicament, including NP optimization and characterization, plus drug release profile of the NPs compared with free Ca(OH)₂. Additionally, the depth and area of penetration of the NPs inside the dentinal tubules of extracted teeth were compared with those of the free Ca(OH)₂.MethodologyCa(OH)₂ NPs were prepared using the solvent displacement method. NPs was optimized with a central composite design to obtain a final optimized formulation. The morphology of the NPs was examined under transmission electron microscopy (TEM), and characterization was carried out using X‐ray diffraction (XRD), Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC). The drug release profile of the Ca(OH)₂ NPs and free Ca(OH)₂ was evaluated up to 48 h. Finally, the depth and area of penetration inside the dentinal tubules of extracted teeth were examined for both the Ca(OH)₂ NPs and free Ca(OH)₂ using the Mann–Whitney U test to determine any significant differences.ResultsUtilizing the optimized formulation, the Ca(OH)₂ NPs had an average size below 200 nm and polydispersity index lower than 0.2, along with a highly negative zeta potential and suitable entrapment efficiency percentage. The spherical morphology of the Ca(OH)₂ NPs was confirmed using TEM. The results of the XRD, FTIR and DSC revealed no interactions and confirmed that the drug was encapsulated inside the NPs. The drug release profile of the Ca(OH)₂ NPs exhibited a prolonged steady release that remained stable up to 48 h with higher concentrations than the free Ca(OH)₂. After examination by confocal laser scanning microscopy, Ca(OH)₂ NPs had a significantly greater depth and area of penetration inside dentinal tubules compared with the free drug.ConclusionsCa(OH)₂‐loaded PLGA NPs were successfully optimized and characterized. The NPs exhibited a prolonged drug release profile and superior penetration inside dentinal tubules of extracted teeth when compared to Ca(OH)2.
Trends in risk classification at diagnosis and choice of primary therapy for prostate cancer: An analysis of 10 839 patients from the Nara Urological Research and Treatment Group registry between 2004 and 2015
Authors: Nakai Yasushi , Tanaka Nobumichi , Fujii Tomomi , Miyake Makito , Anai Satoshi , Hori Shunta , Shimizu Takuto , Onishi Mikiko , Ichikawa Kazuki , Onishi Kenta , Fujimoto Kiyohide 
Published: August 2021

ObjectiveTo evaluate trends in risk classification at diagnosis and choice of primary therapy in patients diagnosed with prostate cancer.MethodsThis retrospective study included 10 839 patients who were newly diagnosed with prostate cancer between 2004 and 2015 at 23 Japanese institutions. Risk classification and primary therapies between 2004 and 2015 were evaluated. The trends in risk classification and primary therapy were evaluated using chi‐squared tests for trend during four periods (2004–2006; 2007–2009; 2010–2012; and 2013–2015). Binary logistic analysis was used to evaluate the extent to which factors such as age, risk classification, and institution influenced primary therapy choice in the 2013–2015 cohort.ResultsThe number of patients with very‐low or low‐risk classification (P < 0.001) and metastasis (P = 0.04) decreased and the number with intermediate‐risk classification (P < 0.001) increased during the four periods. A tendency to choose radical prostatectomy as primary therapy for prostate cancer was not observed during the four periods (P = 0.90). The number of patients who chose radiation therapy (P < 0.001) and active surveillance/watchful waiting (P < 0.001) as primary therapies increased during the four periods and the number of patients who chose androgen deprivation therapy (P < 0.001) decreased. Age, institution, and risk classification significantly influenced primary therapy choice.ConclusionsWe have shown the trends in risk classification of prostate cancer and primary therapy choices between 2004 and 2015 in Japan. Age, institution, and risk classification significantly influenced the decision on primary therapy for prostate cancer.
Neuroimmunology of cancer and associated symptomology
Authors: Scheff Nicole N , Saloman Jami L 
Published: August 2021

AbstractEvolutionarily, the nervous system and immune cells have evolved to communicate with each other to control inflammation and host responses against injury. Recent findings in neuroimmune communication demonstrate that these mechanisms extend to cancer initiation and progression. Lymphoid structures and tumors, which are often associated with inflammatory infiltrate, are highly innervated by multiple nerve types (e.g. sympathetic, parasympathetic, sensory). Recent preclinical and clinical studies demonstrate that targeting the nervous system could be a therapeutic strategy to promote antitumor immunity while simultaneously reducing cancer‐associated neurological symptoms, such as chronic pain, fatigue and cognitive impairment. Sympathetic nerve activity is associated with physiological or psychological stress, which can be induced by tumor development and cancer diagnosis. Targeting the stress response through suppression of sympathetic activity or activation of parasympathetic activity has been shown to drive activation of effector T cells and inhibition of myeloid‐derived suppressor cells within the tumor. In addition, there is emerging evidence that sensory nerves may regulate tumor growth and metastasis by promoting or inhibiting immunosuppression in a tumor‐type specific manner. Because neural effects are often tumor‐type specific, further study is required to optimize clinical therapeutic strategies. This review examines the emerging evidence that neuroimmune communication can regulate antitumor immunity as well as contribute to development of cancer‐related neurological symptoms.
Impact of early childhood caries severity on oral health‐related quality of life among preschool children in Mexico: A cross‐sectional study
Authors: Lara Juan Sebastian , Romano Ariadna , Murisi Pedroza Uribe , Tedesco Tamara Kerber , Mendes Fausto Medeiros , Soto‐Rojas Armando E. , Alonso Celina , Campus Guglielmo 
Published: August 2021

AbstractBackgroundInformation is scarce on Early Childhood Caries (ECC) in Mexican preschool children and its impact on quality of life.AimTo evaluate the ECC prevalence and its impact on OHRQoL in 3–5 years‐old Mexican children according to disease severity.DesignCaries was determined at two thresholds: (1) children with at least one caries lesion (ICDAS‐1‐6) and (2) children with at least one lesion in dentin (ICDAS‐3‐6). OHRQoL was assessed through the Mexican Early Childhood Oral Health Impact Scale (M‐ECOHIS). Associations among caries severity, M‐ECOHIS, and other variables were assessed by ordinal logistic regression.ResultsA total of 409 children participated (53.8% girls, 46.2% boys). Caries prevalence was 82.2% considering all lesions, and 45.0% for dentinal lesions. Significant linear trends (p < .05) among caries levels and categories of exposure were found for socioeconomic variables, dietary habits, and toothbrushing habits. Attending rural private schools (OR = 1.39, 95%CI = 1.11–1.72; p < .01), two main meals/day (OR = 2.75, 95%CI = 1.26–6.03; p = .01) and unsupervised toothbrushing (OR = 3.20, 95%CI = 1.96–5.24; p < .01) increased the risk to have high caries severity levels. M‐ECOHIS scores were statistically significant associated with caries levels (χ2(4) = 175.85, p < .01; trend across groups z = 12.63 Prob > |z| < 0.01).ConclusionsM‐ECOHIS was significantly associated with caries severity. Type of school, age groups, parents’ educational level, family income, and living conditions were correlated with caries, showing how distinctive risk indicators were associated with different caries stages.
Reduction of Salmonella enterica in Turkey breast slices kept under aerobic and vacuum conditions by application of lactic acid, a bacteriophage, and ultrasound
Authors: Aykın‐Dinçer Elif , Ergin Firuze , Küçükçetin Ahmet 
Published: August 2021

AbstractThe effects of different antimicrobial applications against Salmonella enterica subs. enterica DSM 18522 strain in turkey breast slices kept under either aerobic or anaerobic‐vacuum conditions for different keeping times of 30 min and 6 hr at 4°C were evaluated. In this study, it was aimed to compare chemical (lactic acid, 3%), biopreservation (bacteriophage Felix O1, 1 × 108 pfu/ml), and physical (ultrasound, 20 kHz) antimicrobial applications in reducing a high initial S. enterica DSM 18522 count (~6 log cfu/g) in turkey breast slices at different conditions. The highest reduction in S. enterica DSM 18522 counts (1.62 log units) was observed in turkey breast slices kept under aerobic condition for 6 hr after being treated with lactic acid. The bacteriophage application significantly (p < .05) reduced S. enterica DSM 18522 counts 1.22 and 1.41 log cfu/g in turkey breast slices that kept under aerobic and anaerobic‐vacuum conditions for 30 min, respectively. There was no significant effect of keeping time under aerobic or anaerobic‐vacuum conditions on S. enterica DSM 18522 counts in turkey breast slices treated with bacteriophage or ultrasound. However, the reduction of S. enterica DSM 18522 counts in turkey breast slices treated with lactic acid increased with keeping time under aerobic or anaerobic‐vacuum conditions. Regardless of keeping conditions, the lowest reductions in S. enterica DSM 18522 counts were detected in turkey breast slices treated with ultrasound. The results of this study show that lactic acid and bacteriophage applications are effective in reducing S. enterica DSM 18522 counts in turkey breast slices.