bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Buffer Analysis dalam bidang Teknik Sipil dan Lingkungan
Authors: Ridwan Vita Fajriani 
Published: November 2021

Perkembangan teknologi GIS menyediakan konsep, alat, dan analisis yangmendukung kebutuhan teknik sipil dan lingkungan. Tulisan ini membahas secarasingkat konsep buffer analysis/multiple ring buffer analysis pada platform GIS dalamaplikasi teknik sipil dan lingkungan. Tulisan ini menjelaskan penelitian-penelitiansebelumnya yang menerapkan buffer analysis/multiple ring buffer analysis. Bufferanalysis/multiple ring buffer analysis digunakan untuk mengetahui area layanan (halte bus, shelter untuk bencana), yang umum digunakan dalam teknik sipil; dan untuk memahami area dampak (perletakan TPA, kebisingan), yang umum digunakan dalam bidang teknik sipil dan lingkungan. Tulisan ini menyebutkan keterbatasan buffer analysis/multiple ring buffer analysis yang hanya berfokus pada variabel jarak.
On the feasibility of crawling-based attacks against recommender systems
Authors: Aiolli Fabio , Conti Mauro , Picek Stjepan , Polato Mirko 
Published: November 2021

Nowadays, online services, like e-commerce or streaming services, provide a personalized user experience through recommender systems. Recommender systems are built upon a vast amount of data about users/items acquired by the services. Such knowledge represents an invaluable resource. However, commonly, part of this knowledge is public and can be easily accessed via the Internet. Unfortunately, that same knowledge can be leveraged by competitors or malicious users. The literature offers a large number of works concerning attacks on recommender systems, but most of them assume that the attacker can easily access the full rating matrix. In practice, this is never the case. The only way to access the rating matrix is by gathering the ratings (e.g., reviews) by crawling the service’s website. Crawling a website has a cost in terms of time and resources. What is more, the targeted website can employ defensive measures to detect automatic scraping. In this paper, we assess the impact of a series of attacks on recommender systems. Our analysis aims to set up the most realistic scenarios considering both the possibilities and the potential attacker’s limitations. In particular, we assess the impact of different crawling approaches when attacking a recommendation service. From the collected information, we mount various profile injection attacks. We measure the value of the collected knowledge through the identification of the most similar user/item. Our empirical results show that while crawling can indeed bring knowledge to the attacker (up to 65% of neighborhood reconstruction on a mid-size dataset and up to 90% on a small-size dataset), this will not be enough to mount a successful shilling attack in practice.
A importância da hibridização para a preservação da variabilidade genética da família Arecaceae (palmeiras) frente a fatores antropogênicos: uma revisão sobre o caso da palmeira x Butyagrus nabonnandii (Prosch.) Vorste.
Authors: Rosa Lurdes Zanchetta , Almeida Carlos Gabriel Moreira de , Brasil Angela Medeiros de Assis , Laindorf Bruna Lucia , Cogo Maurício RIcardo de Melo , Kuhn Sofia Aumond , Bacega Adrieli , Santos Natanael Lemos dos , Silveira Dienifer Noetzold Blaskesi , Cassol Ana Paula Vestena , Pereira Antônio Batista , Souza Velci Queiroz de 
Published: November 2021

A família Arecaceae, reconhecida mundialmente pela sua importância econômica e ambiental, está em franco declínio populacional devido, principalmente, a ação antropogênica. Este trabalho consiste em uma revisão ampla das publicações científicas sobre a Família e, mais especificamente, dos gêneros Butia (Becc.) Becc. e Syagrus Mart. Aqui reunimos, organizamos e compilamos características botânicas e aspectos biogeográficos dos gêneros mencionados, com o objetivo de fundamentar trabalhos de pesquisa sobre alternativas viáveis à conservação dessas palmeiras e o atendimento das demandas de mercado por mudas dessas espécies tropicais. Uma alternativa proposta é o desenvolvimento de metodologias de hibridização entre esses dois gêneros, a fim de se obter respostas desejáveis para a finalidade comercial e, ao mesmo tempo, implementar planos de preservação para as populações de palmeiras nativas. Os dados levantados foram obtidos a partir de literatura científica em sites e revistas, no período de junho de 2019 a março de 2021. As buscas envolveram obras de 1970 a 2021. Nesta pesquisa exploratória, é primordial enfatizar a importância da interpretação e das opiniões dos pesquisadores, de forma que seja possível integrá-los às obras, proporcionando uma fundamentação teórica que dê sustentação a uma discussão a respeito do tema proposto.
ELECTROCHEMISTRY OF IMMOBILIZED MICROPARTICLES AND MICRODROPLETE: ACCESS TO FUNDAMENTAL DATA OF SOLID MATERIALS AND IONS
Authors: Scholz Fritz 
Published: November 2021

The idea to study the electrochemistry of immobilized microparticles has been published by this author for the first time in 1989. In the last 32 years, this approach has been shown to be very successful not only for analytical characterization of solid materials, but also applicable to extract thermodynamic and kinetic data, and even to determine the age of metal specimen. In 2000, it has been shown that the electrochemistry of immobilized microdroplets gives an elegant access to determine the Gibbs free energies of ion transfer between immiscible solvents. These measurements are performed with a standard 3-electrode potentiostate and can be used also for solvents, which cannot be used in experiments with the classical 4-electrode technique.
The electrochemistry of microparticles and microdroplets share several common features with respect to the electrode mechanisms: in both cases three-phase electrodes are realized and ion and electron transfer proceed simultaneously.
This talk reviews the activities of the speaker and his cooperation partners during the last 3 decades paying special attention to those results, which are of general interest.
Stability Evaluation of Different Oblique Lumbar Interbody Fusion Constructs in Normal and Osteoporotic Condition – A Finite Element Based Study
Authors: Bereczki Ferenc , Turbucz Mate , Kiss Rita , Eltes Peter Endre , Lazary Aron 
Published: November 2021

Introduction: In developed countries, the age structure of the population is currently undergoing an upward shift, resulting a decrease in general bone quality and surgical durability. Over the past decade, oblique lumbar interbody fusion (OLIF) has been globally accepted as a minimally invasive surgical technique. There are several stabilization options available for OLIF cage fixation such as self-anchored stand-alone (SSA), lateral plate-screw (LPS), and bilateral pedicle screw (BPS) systems. The constructs’ stability are crucial for the immediate and long-term success of the surgery. The aim of this study is to investigate the biomechanical effect of the aforementioned constructs, using finite element analysis with different bone qualities (osteoporotic and normal).Method: A bi-segmental (L2–L4) finite element (FE) model was created, using a CT scan of a 24-year-old healthy male. After the FE model validation, CAD geometries of the implants were inserted into the L3–L4 motion segment during a virtual surgery. For the simulations, a 150 N follower load was applied on the models, then 10 Nm of torque was used in six general directions (flexion, extension, right/left bending, and right/left rotation), with different bone material properties.Results: The smallest segmental (L3–L4) ROM (range of motion) was observed in the BPS system, except for right bending. Osteoporosis increased ROMs in all constructs, especially in the LPS system (right bending increase: 140.26%). Osteoporosis also increased the caudal displacement of the implanted cage in all models (healthy bone: 0.06 ± 0.03 mm, osteoporosis: 0.106 ± 0.07 mm), particularly with right bending, where the displacement doubled in SSA and LPS constructs. The displacement of the screws inside the L4 vertebra increased by 59% on average (59.33 ± 21.53%) due to osteoporosis (100% in LPS, rotation). BPS-L4 screw displacements were the least affected by osteoporosis.Conclusions: The investigated constructs provide different levels of stability to the spine depending on the quality of the bone, which can affect the outcome of the surgery. In our model, the BPS system was found to be the most stable construct in osteoporosis. The presented model, after further development, has the potential to help the surgeon in planning a particular spinal surgery by adjusting the stabilization type to the patient’s bone quality.
RAP: A Novel Approach to the Rapid and Highly Sensitive Detection of Respiratory Viruses
Authors: Fan Guohao , Zhang Ruiqing , He Xiaozhou , Tian Fengyu , Nie Mingzhu , Shen Xinxin , Ma Xuejun 
Published: November 2021

Recombinase aided amplification (RAA) is an emerging isothermal amplification method used for detecting various pathogens. However, RAA requires a complex and long probe to ensure high sensitivity during fluorescence assay. TaqMan probe used for quantitative PCR (qPCR) is simple and universal. Herein, we developed a new approach for detecting nucleic acids of pathogens, known as RAP (Recombinase aided PCR). The method combines RAA and qPCR to ensure a rapid and highly sensitive detection using a conventional qPCR device. RAP is a two-stage amplification process performed in a single tube within 1 hour. The method involves an RAA reaction for 10 min at 39°C (first stage) followed by 15 cycles of qPCR (second stage). Using human adenovirus 3 (HADV3) and human adenovirus 7 (HADV7) plasmids, the sensitivities of RAP assays for detecting HADV3 and HADV7 were 6 and 17 copies per reaction, respectively. The limit of RAP detection was at least 16-fold lower than the corresponding qPCR, and no-cross reaction with other respiratory viruses was observed. The results of RAP analysis revealed 100% consistency with qPCR assay. This study shows that RAP assay is a rapid, specific, and highly sensitive detection method with a potential for clinical and laboratory application.
The Dark Side of Pyroptosis of Diffuse Large B-Cell Lymphoma in B-Cell Non-Hodgkin Lymphoma: Mediating the Specific Inflammatory Microenvironment
Authors: Wang Wei , Xu Shi-wen , Teng Ya , Zhu Min , Guo Qun-yi , Wang Yuan-wen , Mao Xin-Li , Li Shao-wei , Luo Wen-da 
Published: November 2021

Background: Diffuse large B-cell lymphoma (DLBCL) is a common aggressive B-cell non-Hodgkin lymphoma (B-NHL). While combined chemotherapy has improved the outcomes of DLBCL, it remains a highly detrimental disease. Pyroptosis, an inflammatory programmed cell death, is considered to have both tumor-promoting and tumor-suppressing effects. The role of pyroptosis in DLBCL has been gradually appreciated, but its value needs further investigation.Methods: We analyzed mutations and copy number variation (CNV) alterations of pyroptosis-related genes (PRGs) from The Cancer Genome Atlas (TCGA) cohort and evaluated the differences in expression in normal B cells and DLBCL patients in two Gene Expression Omnibus (GEO) datasets (GSE12195 and GSE56315). Based on the expression of 52 PRGs, we divided 421 DLBCL patients from the GSE31312 dataset into distinct clusters using consensus clustering. The Kaplan-Meier method was used to prognosis among the three clusters, and GSVA was used to explore differences in the biological functions. ESTIMATE and single-sample gene-set enrichment analysis (ssGSEA) were used to analyze the tumor immune microenvironment (TME) in different clusters. A risk score signature was developed using a univariate survival analysis and multivariate regression analysis, and the reliability and validity of the signature were verified. By combining the signature with clinical factors, a nomogram was established to predict the prognosis of DLBCL patients. The alluvial diagram and correlation matrix were used to explore the relationship between pyroptosis risk score, clinical features and TME.Results: A large proportion of PRGs are dysregulated in DLBCL and associated with the prognosis. We found three distinct pyroptosis-related clusters (cluster A, B, and C) that differed significantly with regard to the prognosis, biological process, clinical characteristics, chemotherapeutic drug sensitivity, and TME. Furthermore, we developed a risk score signature that effectively differentiates high and low-risk patients. The nomogram combining this signature with several clinical indicators showed an excellent ability to predict the prognosis of DCBCL patients.Conclusions: This work demonstrates that pyroptosis plays an important role in the diversity and complexity of the TME in DLBCL. The risk signature of pyroptosis is a promising predictive tool. A correct and comprehensive assessment of the mode of action of pyroptosis in individuals will help guide more effective treatment.
Starch-Based Carbon Dots for Nitrite and Sulfite Detection
Authors: Wang Panyong , Zhang Yan , Liu Yulu , Pang Xinpei , Liu Pai , Dong Wen-Fei , Mei Qian , Qian Qing , Li Li , Yan Ruhong 
Published: November 2021

Nitrite and sulfite play important roles in human health and environmental science, so it is desired to develop a facile and efficient method to evaluate NO2- and SO32- concentrations. In this article, the use of green alternatives with the potential of multi-functionality has been synthesized to detect nitrite and sulfite based on fluorescent probe. The carbon dots (CDs) with starch as only raw materials show fluorescence turn “on-off-on” response towards NO2- and SO32- with the limits of detection of 0.425 and 0.243 μМ, respectively. Once nitrite was present in the solution, the fluorescence of CDs was quenched rapidly due to the charge transfer. When sulfite was introduced, the quenching fluorescence of CDs was effectively recovered because of the redox reaction between NO2- and SO32-, and thus providing a new way for NO2- and SO32- detection. Owing to their excellent analytical characteristics and low cytotoxicity, the “on-off-on” sensor was successfully employed for intracellular bioimaging of NO2- and SO32-.
A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure
Authors: Luo Jin-Wen , Duan Wen-Hui , Song Lei , Yu Yan-Qiao , Shi Da-Zhuo 
Published: November 2021

Background: Previous studies had reported increased circulating concentrations of growth differentiation factor-15 (GDF-15) in chronic heart failure (CHF), suggesting the potential prognostic significance of GDF-15 in this setting. To verify the relationship between the circulating GDF-15 levels and prognosis of CHF patients, we conducted an updated evidence-based meta-analysis.Methods: A comprehensive literature retrieval of PubMed, EMBASE, and Cochrane library was performed to collect the qualified studies that analyzed the prognostic value of GDF-15 in CHF from the inception of these online databases to September 25, 2021. The hazard ratio (HR) calculated for logGDF-15 of all-cause death and the related 95% confidence interval (CI) in multivariate analysis were used to measure the effect size. Additionally, subgroup analyses stratified by characteristics of the study participants were conducted for incremental evidence of GDF-15 in CHF with different clinical status.Results: A total of ten eligible studies involving 6,244 CHF patients were finally taken into the quantitative analysis. Results in the random-effects model indicated that there was an increased risk of 6% in all-cause mortality with a per 1LnU increase in baseline GDF-15 concentration (HR: 1.06, 95% CI: 1.03–1.10, P &lt; 0.001). In stratified analyses, the association of GDF-15 with risk of all-cause mortality was found among chronic ischemic HF patients (HR:1.75, 95%CI: 1.24–2.48, P = 0.002), while the association was not found among chronic nonischemic HF patients (HR:1.01, 95%CI: 1.00–1.02, P = 0.219).Conclusion: The elevated GDF-15 is associated with an increased risk of all-cause mortality in CHF, especially, among CHF patients with ischemic etiology. The circulating GDF-15 might be a prognostic indicator in CHF patients.Registration Number:https://www.crd.york.ac.uk/PROSPERO; CRD42020210796.
The Spread of Droplets and Aerosols of Surgical Motor Handpiece Irrigation Using Different Suction Systems
Authors: Tsoi James K. H. , Ding Hao , Hon Ki , Leung Yiu Yan 
Published: November 2021

Objective: This study aimed to compare the effectiveness of various combinations of dental suction devices in reducing the amount and distance of spread of aerosols and droplets using an electrical surgical motor model with a self-irrigation system.Materials and Methods: In a standard single-chaired air-conditioned ventilated dental clinic, an electrical dental surgical motor with a high-speed handpiece (Implantmed) cooled with 0.2% fluorescein containing normal saline was used to drill a gypsum block mounted on a phantom head in a supine position. A single operator performed thrice each of the following suction settings: (a) no suction, (b) low-volume suction, (c) low-volume + high-volume suctions, and (d) low-volume + external oral suctions. Aerosols (0.1–5 μm) were measured with a particle counter at the mouth opening of the phantom head, and droplet sizes and distances were analyzed via a machine learning algorithm by identifying fluorescence droplets on pre-loaded pieces of paper on the floor for each group.Results: The different suction systems have different performances in terms of droplet distance (p = 0.007), whereas using (c) high volume suctions (41.1 ± 22.9 cm) and (d) external oral suction unit (39 ± 18.2 cm) had significantly reduced the spread of droplets when compared with (a) without suction (58.9 ± 17.1 cm). Using (d) external oral suction or (c) high volume suction could reduce the number for all droplet sizes. The use of (c) high volume suction was most effective in reducing aerosol count of 0.3–1 μm, while (d) external oral suction was most effective in reducing aerosol count of 3–5 μm.Conclusions: Both external oral suction and high-volume suction were effective in reducing aerosols and droplets generated by the irrigation of a surgical high-speed motor handpiece. External oral suction could be an effective alternative to high volume suction in dental surgical procedures to reduce the spread of aerosols and droplets.Clinical Relevance: External oral suction or high-volume suction should be used in conjunction with low-volume suction in surgical procedure to reduce the spread of aerosols and droplets in a dental clinic environment.
Influence of Saline Fluids on the Electrical Conductivity of Olivine Aggregates at High Temperature and High Pressure and Its Geological Implications
Authors: Sun Wenqing , Dai Lidong , Hu Haiying , Jiang Jianjun , Wang Mengqi , Hu Ziming , Jing Chenxin 
Published: November 2021

The electrical conductivities of hydrous olivine (Ol) aggregates and Ol–H2O, Ol–NaCl–H2O (salinity: 1–21 wt%; fluid fraction: 5.1–20.7 vol%), Ol–KCl–H2O (salinity: 5 wt%; fluid fraction: 10.9–14.0 vol%) and Ol–CaCl2–H2O systems (salinity: 5 wt%; fluid fraction: 10.7–13.7 vol%) were measured at 2.0–3.0 GPa and 773–1073 K using a multi-anvil apparatus. The electrical conductivity of saline fluid-bearing olivine aggregates slightly increases with increasing pressure and temperature, and the electrical conductivities of both hydrous and saline fluid-bearing samples are well described by an Arrhenius relation. The dihedral angle of the saline fluids is approximately 50° in the Ol–NaCl–H2O system with 5 wt% NaCl and 5.1 vol% fluids, which implies that the fluids were interconnected along grain boundaries under the test conditions. The electrical conductivities of the Ol–NaCl–H2O system with 5 wt% NaCl and 5.1 vol% fluids are ∼two to four orders of magnitude higher than those of hydrous olivine aggregates. The salinity and fluid fraction moderately enhance the sample electrical conductivities owing to the interconnectivity of the saline fluids. The activation enthalpies of the electrical conductivities for the Ol–NaCl–H2O systems range from 0.07 to 0.36 eV, and Na+, Cl−, H+, OH−, and soluble ions from olivine are proposed to be the main charge carriers. For a fixed salinity and fluid fraction, the electrical conductivities of the Ol–NaCl–H2O system resemble the Ol–KCl–H2O system but are slightly higher than that of the Ol–CaCl2–H2O system. The Ol–NaCl–H2O system with a salinity of ∼5 wt% NaCl and fluid fraction larger than 1.8 vol% can be employed to reasonably explain the origin of the high-conductivity anomalies observed in mantle wedges.
The Challenges of Managing Pediatric Diabetes and Other Endocrine Disorders During the COVID-19 Pandemic: Results From an International Cross-Sectional Electronic Survey
Authors: Elbarbary Nancy Samir , dos Santos Tiago Jeronimo , de Beaufort Carine , Wiltshire Esko , Pulungan Aman , Scaramuzza Andrea Enzo 
Published: November 2021

BackgroundFrequency, dimensions, management, and outcomes of the COVID-19 pandemic in children with endocrine disorders and diabetes were assessed.MethodsA cross-sectional electronic survey was distributed to the global network of endocrine societies. Respondents’ professional and practice profiles, clinic sizes, their country of practice, and the impact of COVID-19 on endocrine diseases were investigated.ResultsRespondents from 131 pediatric endocrine centers in 51 countries across all continents completed the survey. Routine check-ups and education were altered in most pediatric endocrine clinics. Over 20% of clinics experienced a shortage of critical medications or essential supplies. ICU treatment was required for patients with diabetes and COVID-19 in 21.2% of centers. In diabetes, 44% of respondents reported increased diabetic ketoacidosis episodes in newly diagnosed cases and 30% in established cases. Biopsychosocial and behavioral changes were explicitly reported to be occurring among pediatric patients with endocrine disorders.ConclusionsThis large global survey conducted during the COVID-19 pandemic highlights that diabetes is more challenging to manage than any other pediatric endocrine disorder, with an increased risk of morbidity. Psychological distress due to COVID-19 needs to be recognized and addressed. The importance of close contact with healthcare professionals should be emphasized, and medical supplies should be readily available to all patients.
Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma
Authors: Wang Yichao , Zhou Shengliang , Wang Dun , Wei Tao , Zhu Jingqiang , Li Zhihui 
Published: November 2021

BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which could be used as a biomarker for predicting PTC.MethodsSerum samples were collected from 29 PTC patients and 29 nodular goiter (NG) patients. Five PTC serum samples and five NG serum samples were selected for proteome profiles by proteomics. Eight proteins in PTC and NG serum samples were selected for confirmation by enzyme-linked immunosorbent assay analysis. Receiver operating characteristic curves was used to evaluate the diagnostic value of potential biomarkers.ResultsComplement C4-A (C4A) and plasminogen (PLG) were significantly lower in serum samples of PTC patients compared with NG patients. C4A was observed to have excellent diagnostic accuracy for PTC, with a sensitivity of 91.67% and specificity of 83.33%. The diagnostic value of PLG for PTC was demonstrated by a sensitivity at 87.50% and specificity at 75.00%. The AUC for C4A and PLG was 0.97 ± 0.02 and 0.89 ± 0.05.ConclusionC4A and PLG appeared to be excellent potential biomarkers for the prediction of PTC.