bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Urban Population Health Observatory System to Support COVID-19 Pandemic Preparedness, Response, and Management: Design and Development Study
Authors: Brakefield Whitney S , Ammar Nariman , Olusanya Olufunto A , Shaban-Nejad Arash 
Published: May 2021

Background
COVID-19 is impacting people worldwide and is currently a leading cause of death in many countries. Underlying factors, including Social Determinants of Health (SDoH), could contribute to these statistics. Our prior work has explored associations between SDoH and several adverse health outcomes (eg, asthma and obesity). Our findings reinforce the emerging consensus that SDoH factors should be considered when implementing intelligent public health surveillance solutions to inform public health policies and interventions.

Objective
This study sought to redefine the Healthy People 2030’s SDoH taxonomy to accommodate the COVID-19 pandemic. Furthermore, we aim to provide a blueprint and implement a prototype for the Urban Population Health Observatory (UPHO), a web-based platform that integrates classified group-level SDoH indicators to individual- and aggregate-level population health data.

Methods
The process of building the UPHO involves collecting and integrating data from several sources, classifying the collected data into drivers and outcomes, incorporating data science techniques for calculating measurable indicators from the raw variables, and studying the extent to which interventions are identified or developed to mitigate drivers that lead to the undesired outcomes.

Results
We generated and classified the indicators of social determinants of health, which are linked to COVID-19. To display the functionalities of the UPHO platform, we presented a prototype design to demonstrate its features. We provided a use case scenario for 4 different users.

Conclusions
UPHO serves as an apparatus for implementing effective interventions and can be adopted as a global platform for chronic and infectious diseases. The UPHO surveillance platform provides a novel approach and novel insights into immediate and long-term health policy responses to the COVID-19 pandemic and other future public health crises. The UPHO assists public health organizations and policymakers in their efforts in reducing health disparities, achieving health equity, and improving urban population health.
3D Modeling of Subsurface Lawanopo Fault In Southeast Sulawesi, Indonesia Using Grablox and its Consequence to Geohazard
Authors: Triani Triani , Umam Rofiqul , Sismanto Sismanto 
Published: May 2021

Lawanopo Fault is a horizontal shear fault (sinistral strike-slip) found in Southeast Sulawesi province and is thought to be active during Plio-Pleistocene or mid-late Miocene to the present. This study has been carried out which aims to find out the geometric shapes below the surface of the Lawanopo fault using complete Bouguer anomaly (ABL) data. The ABL data is projected onto a flat plane using the Dampney method at an altitude of 8 km, and the separation of local and regional anomalies is carried out using the upward continuation method at an altitude of 60 km. Three-dimensional (3D) modeling under the surface of the Lawanopo fault is done using the computer program Grablox. Data processing techniques using Singular Value Decomposition (SVD) and Occam inversion. The results showed that a high gravity anomaly of 190-225 mGal was caused by an igneous rock below the surface with a density of 2.7-3.33 gr/cm3 and a thickness of about 13 km, a moderate anomaly of 175-187 mGal caused by Paleozoic igneous rocks aged Carbon with a density of 2.6-2.9 gr/cm3 and a thickness of about 25 km. Low anomaly 115-160 mGal is caused by rocks with a density of 2.0-2.5 gr/cm3 and a thickness of about 22-23 km. The Lawanopo fault constituent rocks consist of alkaline rocks in the basement covered by sediment and metamorphic with a depth of Lawanopo fault more than 15 km and begin to be seen at a depth of 4.3 km of the surface. it is known that the area around the Lawanopo fault is an area prone to earthquakes. But, based on the soil and rock structure around the Lawanopo fault, the compactness and attenuation levels in reducing earthquake waves are quite good, so that land use around the Lawanopo fault tends to be safe.
Social Capital and Social Capacity in Rural Ecotourism Development
Authors: Nugroho Iwan , Hanafie Rita , Negara Purnawan Dwikora , Sudiyono Sudiyono , Yuniar Hefifa Rhesa 
Published: May 2021

The participation of rural people in ecotourism activity remains the question, whether they genuinely carry the vision of conservation or are forced to engage in meeting economic needs only. This question is fundamental for building better participation and management of ecotourism in rural areas. The research aims to discuss social capital and social capacities to empower ecotourism in rural areas. The study was carried out in the villages of Ngadas and Gombengsari using a survey approach, and employing descriptive and path analysis methods. The results show that social capital for managing ecotourism services demonstrated the functioning of institutions, networking capabilities, monitoring, evaluation, and innovation. Social capacity is related to the regulation of institutional, social, economic, and environmental resources. Social capacity was found more substantial in Gombengsari than Ngadas village. The research is expected to strengthen the study of social capital as a stock/sink and its relationship with sustainability.
Adhesive compound of composite materials in conditions of accelerated climatic aging
Authors: Martynov Gleb V. , Monastyreva Daria E. , Astafieva Natalia S. 
Published: May 2021

Introduction. Pultruded fiberglass can be called the material of the future due to its properties — high strength, low weight, resistance to aggressive environment. Important aspects for the development of composite materials are surface treatment methods and methods of connecting structural elements. Glue compound has proven itself as the most effective, but there remains a need to conduct studies of its durability. The method of accelerated cyclic thermal tests allows to determine the expected changes in the strength of adhesive bonding in a short time.
Materials and methods. Samples, which are three glued plates of SPPS fiberglass construction, were processed in a climate chamber and after each cycle they were tested on a GRM-1 machine. One climatic test cycle included being in a chamber with high humidity and temperature and then moving into the cold chamber. The specimens were tested prior to spalling, and the resulting disruptive stresses were recorded. The last test cycle corresponded to five years of operation of the structure.
Results. The tests of the samples showed a significant change in the characteristics of the compounds over time. In the first two years of operation, a decrease in strength of 25 % is expected. The last characteristic test point, corresponding to five years, showed a drop to 60 % of the initial characteristics.
Conclusions. The results should be considered at the design stage of supporting structures that are not protected from contact with the external environment. The factors of strength reduction after 100 years may be included in the regulatory documents for the calculation of especially important structures.
Calculation of indoor air temperature using dimensionless parameters for integrated climate control systems
Authors: Samarin Oleg D. 
Published: May 2021

Introduction. It is noted that the improvement of the technology for calculating the thermal regime of premises in the conditions of automation of climate systems is still relevant. The aim of the work is to find a universal dependence of the air temperature in the building premises on time in conditions of a jump in heat access or heat loss for the integral law of regulating the compensatory heat flow from microclimate systems. In the form of a scientific hypothesis, we consider the statement about the power nature of such a dependence with the presence of a maximum and an asymptotic tendency to zero.
Materials and methods. The study involves the use of basic equations that relate the most significant components of heat flows in rooms serviced by microclimate systems equipped with integrated controllers under conditions of abrupt changes in thermal disturbances. The method of dimension analysis is used to identify dimensionless complexes that are essential for obtaining engineering dependencies, as well as software calculation of sums of infinite series with a given accuracy, numerical solution of nonlinear equations, and the method of power series economization.
Results. An analytical expression is found for changes in room temperature under integrated control of climate equipment under conditions of a jump in heat availability, which has the form of an infinite series in degrees of a dimensionless parameter that characterizes the properties of the room and the automation system. A simplified expression for the deviation of air temperature is obtained and a formula for the required control time is derived, as well as its estimation is given on the example of one residential building in the climatic conditions of Moscow.
Conclusions. It is shown that the dependence of the air temperature in a room serviced by microclimate systems with integrated controllers on time is represented in a universal dimensionless form, suitable for any objects regardless of their specific characteristics. The previously discovered relationships for the moment of maximum deviation and the value of the dynamic control error depending on the air exchange of the room, the transmission coefficient of the controller and the room’s own heat stability are confirmed and refined.
Corroboration Development and Regulatory approval of Fibrin Sealant
Authors: Avni Shah  , Viqar Ahmed  , Piyush Patel  , Bhavin Trivedi  , Sagar Vidya 
Published: May 2021

Objective
Finding the relation between scientific evidence development and regulatory approval of medical devices in existing markets, USA (United states of America) and EU (European Union)
Design
To understand this relation, we used evidence development of fibrin sealant as a case study. In general fibrin sealant is a good case study because there is a lot of information available about it.
A systematic review method based on the Cochrane handbook was used to find the evidence development regarding fibrin sealant. We investigated different indications of fibrin sealant, the year of publication, and the phases in clinical trials. To find the procedures and requirements of the approval for fibrin sealant, we searched the government website of their regulatory agencies FDA (Food and Drug Administration), EMA (European Medicine Agency), and CFDA (China Food and Drug Administration).
Results
The relation between evidence development and approval, we found that the cumulative publications of fibrin sealant increased almost in a straight line from 1998 to 2019. Regarding the applications of fibrin sealant, in the first four years after 1998, no new applications were approved, the next four years, two applications were approved, in the four years after that, there were four new applications.
Conclusions
In the first years, the amount of new approved applications is very low, compared to the amount of new publications, but afterwards it goes much faster. Even though fibrin sealant seems to be a Medical Device, the regulatory approval takes time to catch up. For the future research, it would be interesting to also include sales data of fibrin sealant to analyse how sales data influences the medical device companies’ strategies for publication and market approval.
Clinical diagnostic and treatment of COVID 19 of bilateral pneumonia: Case report
Authors: Otljanski A , Kipevska K 
Published: May 2021

In 2019 year the world was attacked with corona virus (SARS-CoV-2) and in march 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic.The symptoms and clinical state in this COVID-19 infection was different, from asymptomatic to mild and severe symptoms, which presented different form of disease: mild, moderate or severe, with or without complications. We presented case with COVID 19 pneumonia as one of the form of COVID infection, with diagnosis, treatment and all investigations we done in our hospital. With complex treatment of this virus infection we successful improved the clinical state of patients with COVID 19 pneumonia.
Keywords: coronavirus, SARS-CoV-2, COVID-19, COVID 19 pneumonia
A Pharmacological Potential of Adina cordifolia
Authors: Dalu Aishwarya P. , Zagare Vinayak S. , Avchar Priyamala E. , Kadam Megha P. , Ingole Ashwini S. , Nagrik Shatrughna U. , Patil Prashant A. 
Published: May 2021

Adina cordifolia belongs to the Rubiaceae family. Flavonoids, carbohydrate, alkaloid, saponin, phenol, tannins, terpenoids, and cardiac glycosides were found in Adina cordifolia plant extracts. Herbal medicines have been the highly esteemed source of medicine throughout human history. They are widely used today indicating that herbs are a growing part of modern, high-tech medicine. The medicinal plants, besides having natural therapeutic values against various diseases and considerable works have been done on these plants to treat chronic Cough, Jaundice, Stomachaches, Cancer, Diabetes, and a variety of other ailments. Present review deals with botanical description and various pharmacological action, and medicinal uses of Adina cordifolia.
Keywords: Adina cordifolia, Pharmacological Potential, Extract, Taxonomy.
Use of Antibiotics in Upper Respiratory Tract Infections in Tertiary Care Teaching Hospital of Delhi
Authors: Zulqarnain Md. , Singh Sanjit , Prasad Abhishek , Abdullah , , Palit Tanaya 
Published: May 2021

The aim of this study was to evaluate the prescribing pattern of antibiotics in URTI patients attending the OPD and IPD of HAHC Hospital, a tertiary care teaching hospital of Jamia Hamdard, associated with HIMSR, New Delhi.
URTI account for millions of visits to family physicians each year. Although warranted in some cases, antibiotics are greatly overused. In the present study, an overall antibiotic prescription rate for adult patients with URTI was 45.6% whereas 54.4% patients were on non-antibiotic treatment. In our study the antibiotics were prescribed in 10.5% cases of common cold, 76.47% cases of pharyngitis, 63.15% cases of laryngitis, 100% cases of otitis media and 52.38% cases of sinusitis. The most commonly prescribed antibiotic was azithromycin which was prescribed collectively in 70.3% cases of common cold, pharyngitis, laryngitis, and sinusitis. The combination of amoxicillin and clavulanic acid was prescribed in remaining 29.7% cases suffering from pharyngitis. sinusitis, and otitis media. The antibiotic prescription at Hospital is in line with the ICMR guidelines for URTIs.
We found adverse drug reactions in only 9% cases receiving azithromycin and combination of amoxicillin and clavulanic acid. The adverse drug reaction reported with azithromycin was diarrhoea, stomach pain, nausea and vomiting whereas only diarrhoea was reported with amoxicillin and clavulanic acid combination. No other unexpected adverse drug reaction was observed in this study.
Keywords: URTI, Antibiotics, Azithromycin and co-morbidities.
Formulation of shea butter Nanoparticle containing griseofulvin: a combination of antifungal and anti-inflammatory treatments
Authors: Dieng Sidy Mouhamed , Séne Madieye , Fall Ahmedou Bamba Koueimel , Diop Moussa , Sy Papa Mady , Diouf Louis Augustin Diaga , Djiboune Alphonse Rodrigue , Soumboundou Mamadou , Mbaye Gora , Diarra Mounibé , Thioune Oumar 
Published: May 2021

Nanomedicine has been a booming industry with the development of nanovectors to encapsulate water-soluble or amphiphilic molecules for drug delivery. As the new therapeutic agents synthesized are increasingly lipophilic, the development of new nanoparticulate vectors allowing their transport and targeting is now a major challenge. These particles are lipid nanoparticles, a few hundred nanometers in diameter, stabilized by a layer of surfactants composed of castor oil and stealth agents. Solid lipid nanoparticles based on shea butter, stabilized by cremophor® ELP, encapsulating griseofulvin, were formulated by the temperature phase inversion method. The shea butter nanoparticles thus obtained were the subject of characterization relating to: determination of the morphology, size, polydispersity index, pH and zeta potential. The results confirm the stability of our preparations. The anti-inflammatory activity of shea butter being known, the tests were carried out on mice. The inflammation was induced by a solution of croton oil acetone. There is a very big improvement in anti-inflammatory activity. This is due to better penetration of the preparation through the different layers of the skin. Griseofulvin release studies have been carried out on our various preparations. Systems designed as reservoirs of active ingredients and intended for a priori controlled release obey kinetics of the order of one-half (½) corresponding to a proportionality between the quantity released and the square root of time. Shea butter in nanoparticulate forms has thus enabled us to considerably prolong the release of griseofulvin.
Keywords: Nanoparticles; Shea Butter; Inflammation; Griseofulvin.
Review Article Trigonella foenum graecum (Methi): An important botanical drug of Unani system of medicine for the management of gynecological disorders
Authors: Ansari Shamim , Begum Wajeeha , Ahmad Haqeeq 
Published: May 2021

Hulbah (methi) is a botanical drug used in traditional system of medicine and claimed to be effective in the management of gynecological disorders. In this study the aim is to review the role of Hulbah in the management of gynecological disorders (like Warm-e-Rahim, Warm-e-Unq-ur-Rahim, Cervicitis, galactogouge, dysmenorrhea uterine tonic, emmenagogue, labour pain, Mudirr-e-boul, Mudirr-e-Haiz, Mushile Wilaadat, Salabat Rehm, Warm-e-Rehm, Quruhal Rahim) as mentioned in Unani literature. A review of literature on Hulbah was undertaken using the bibliographic database viz. Pub Med, Google Scholar, Science Direct and Scopus. The search was conducted using the terms ‘Hulbah’, ‘Methi’, ‘Trigonella foenum-gracum’, ‘Fenugreek ’and ‘Hu Lu Ba’. Further, books published in Urdu and English were used to compile the information as representative literature in Unani medicine. The result of review enumerated that Hulbah as such and as an ingredient in various formulations has been used for the management of gynecological disorders since ancient times mainly by the practitioners of traditional medicines. Literature of Unani medicine clearly indicated that Hulbah and its different formulations are safe in gynecological disorders. Sufficient information in respect of Antiarthritic effect, Antibacterial and Antifungal activity, Hypolipidemic effect, Anthelmintic activity, Estrogenic activities, Effect on polycystic ovarian syndrome, Anti-inflammatory and analgesic activities etc., of Hulbah are available. Hulbah and its formulations have been claimed by Unani medicine to be useful in the management of gynecological disorders. Modern scientific reports though scarce, also suggest the possibility of such an effect.
Keywords: Methi: Hulbah: Trigonella foenum gracium: Fenugreek
Risk modeling at the pre-investment phase of nuclear powerplant construction on the international market
Authors: Graboviy Petr , Berezka Vitaly 
Published: May 2021

Involvement in the construction of nuclear power plants worldwide is a promising direction for developing the re-search and technological potential of engineering and general contracting companies in Russia. Nevertheless, Russian companies, involved in the construction of nuclear power plants (NPPs) abroad, need to adapt to foreign jurisdictions, their requirements and rules applied to the construction of hazardous industrial facilities, as well as unique social, economic and physical environments. In this regard, international activities, performed by Russian companies, are associated with uncertainty and risks that require the study and systematization of risk factors and development of risk management models.
The statistical data, covering the recent ten-year period, illustrates the level of uncertainty and problems arising in this area. Over 60 % of nuclear reactors worldwide are built with a delay in construction. The consequences of such delays boost project costs. Major international corporations, implementing nuclear power plant construction projects abroad, consider the insufficient pre-project study of project organization and management issues at the stage of entering into an EPC (M) contract to be the risk factors arising in the pre-investment phase.
Risk management modeling is considered as the main element of the system designated for managing the organizational and economic reliability of the pre-investment phase of NPP construction in the international market. It includes: (a) structuring a multiparametric risk factor space based on four sources, including, on the part of the customer, the EPC (M) contractor, the contract and the external environment; (b) a pre-investment risk management model, applicable to NPP construction abroad, to be based on the overall project risk P(rt1); (c) a mathematical model for selecting a project implementation option based on the multicriterial optimization of the future-oriented project plan-schedule.
The situation and solutions to develop Green Building in Vietnam
Authors: Hai Doan Duong , Hong Duyen Dang Thi , Doan Hai Uyen 
Published: May 2021

Housing in Vietnames megacities is quite expensive due to limited land availability. Besides, green housing investment requires higher implementation costs than non-green housing investments, plus a Green Building certification fee implemented by international organizations. Despite specific difficulties and problems, green real estate projects bring economic benefits to both investors and users in the long run.
Green building development is a trend that is particularly interested in by governments and real estate developers.
Through analyzing the current status of Green Building development in Vietnam, the authors have discovered barriers, limitations, and proposed solutions.
To develop green buildings effectively, investors need to operate a 5-step process throughout the project life cycle, including Green planning — Green design — Green construction — Green operation — Green lifestyle. Using environmentally friendly materials, energy-saving efficiency in green housing is no longer an unattainable dream for urban residents in Vietnam.