bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal variation in reversal learning reveals greater female cognitive flexibility in African striped mice
Authors: Rochais Céline , Hotte Hoël , Pillay Neville 
Published: October 2021

AbstractCognitive flexibility describes the ability of animals to alter cognitively mediated behaviour in response to changing situational demands, and can vary according to prevailing environemental conditions and individual caracteristics. In the present study, we investigated (1) how learning and reversal learning performance changes between seasons, and (2) how cognitive flexibility is related to sex in a free-living small mammal. We studied 107 African striped mice, Rhabdomys pumilio, in an arid semi-desert, 58 during the hot dry summer with low food availability, and 49 during the cold wet winter with higher food availability. We used an escape box task to test for learning and reversal learning performance. We found that learning and reversal learning efficiency varied seasonally by sex: females tested in summer were faster at solving both learning and reversal tasks than males tested in winter. Performance varied within sex: males tested in winter showed faster learning compared to males tested in summer. During reversal learning, females tested in summer were more efficient and solve the task faster compared to females tested in winter. We suggest that seasonal cognitive performance could be related to sex-specific behavioural characteristics of the species, resulting in adaptation for living in harsh environmental conditions.
Depiction of mosaic perfusion in chronic thromboembolic pulmonary hypertension (CTEPH) on C-arm computed tomography compared to computed tomography pulmonary angiogram (CTPA)
Authors: Maschke Sabine K. , Werncke Thomas , Dewald Cornelia L. A. , Becker Lena S. , Meine Timo C. , Olsson Karen M. , Hoeper Marius M. , Wacker Frank K. , Meyer Bernhard C. , Hinrichs Jan B. 
Published: October 2021

AbstractTo evaluate mosaic perfusion patterns and vascular lesions in patients with chronic thromboembolic pulmonary hypertension (CTEPH) using C-Arm computed tomography (CACT) compared to computed tomography pulmonary angiography (CTPA). We included 41 patients (18 female; mean age 59.9 ± 18.3 years) with confirmed CTEPH who underwent CACT and CTPA within 21 days (average 5.3 ± 5.2). Two readers (R1; R2) independently evaluated datasets from both imaging techniques for mosaic perfusion patterns and presence of CTEPH-typical vascular lesions. The number of pulmonary arterial segments with typical findings was evaluated and the percentage of affected segments was calculated and categorized: < 25%; 25–49%; 50–75%; < 75% of all pulmonary arterial segments affected by thromboembolic vascular lesions. Inter-observer agreement was calculated for both modalities using the intraclass-correlation-coefficient (ICC). Based on consensus reading the inter-modality agreement (CACTcons vs. CTPAcons) was calculated using the ICC. Inter-observer agreement was excellent for central vascular lesions (ICC > 0.87) and the percentage of affected segments (ICC > 0.76) and good for the perceptibility of mosaic perfusion (ICC > 0.6) and attribution of the pattern of mosaic perfusion (ICC > 0.6) for both readers on CACT and CTPA. Inter-modality agreement was excellent for the perceptibility of mosaic perfusion (ICC = 1), the present perfusion pattern (ICC = 1) and central vascular lesions (ICC = 1). However, inter-modality agreement for the percentage of affected segments was fair (ICC = 0.50), with a greater proportion of identified affected segments on CACTcons. CACT demonstrates a high agreement with CTPA regarding the detection of mosaic perfusion. CACT detects a higher number of peripheral vascular lesions compared to CTPA.
Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum
Authors: Choi Sungmi , Baek Min-gyung , Chung Myung-Jun , Lim Sanghyun , Yi Hana 
Published: October 2021

AbstractLactiplantibacillus plantarum, previously named “Lactobacillus plantarum,” is found in a wide variety of environments exhibiting a high level of intraspecies genetic diversity. To investigate the strain diversity, we performed comparative genomic analyses of the 54 complete genome sequences. The results revealed that L. plantarum subsp. plantarum was split into three lineages, A, B and C. Of the genes beneficial for probiotic activity, only those associated with the biosynthesis of plantaricin (Pln), an L. plantarum-specific bacteriocin, were found to be significantly different among the lineages. The genes related to the biosynthesis of plnE/F were conserved throughout the three lineages, whereas the outgroups did not possess any Pln-producing genes. In lineage C, the deepest and ancestral type branch, plnE/F genes, were well conserved. In lineage B, loss of gene function was observed due to mobile elements in the pln loci. In lineage A, most strains were predicted to produce more than one type of Pln by possessing diverse Pln-encoding genes. These results showed the presence of functional diversity arising from the trifurcating evolution in L. plantarum subsp. plantarum and demonstrated that Pln is an indicator for differentiating the three lineages.
Development of a reverse transcription recombinase-aided amplification assay for detection of Getah virus
Authors: Nie Mincai , Deng Huidan , Zhou Yuancheng , Sun Xiangang , Huang Yao , Zhu Ling , Xu Zhiwen 
Published: October 2021

AbstractGETV, an arbo-borne zoonotic virus of the genus Alphavirus, which causes diarrhea and reproduction disorders in swine, lead to serious economic losses to the swine industry in China. At present, the existing methods for GETV detection are time-consuming and low sensitivity, so, a rapid, accurate and sensitive GETV detection method is urgently needed. In this study, a fluorescent reverse transcription recombinase-assisted amplification method (RT-RAA) was successfully established for the rapid detection of GETV. The sensitivity of this method to GETV was 8 copies/reaction and 20 TCID50/reaction. No cross-reaction with other viruses. A total of 118 samples were prepared for GETV detection using fluorescent RT-RAA and SYBR Green I RT-qPCR, the coincidence rate of the two methods was 100%. The results suggest that the RT-RAA method is rapid, sensitive and specific for GETV detection and can be applied in the clinical.
A prospective evaluation of AI-augmented epidemiology to forecast COVID-19 in the USA and Japan
Authors: Arık Sercan Ö. , Shor Joel , Sinha Rajarishi , Yoon Jinsung , Ledsam Joseph R. , Le Long T. , Dusenberry Michael W. , Yoder Nathanael C. , Popendorf Kris , Epshteyn Arkady , Euphrosine Johan , Kanal Elli , Jones Isaac , Li Chun-Liang , Luan Beth , Mckenna Joe , Menon Vikas , Singh Shashank , Sun Mimi , Ravi Ashwin Sura , Zhang Leyou , Sava Dario , Cunningham Kane , Kayama Hiroki , Tsai Thomas , Yoneoka Daisuke , Nomura Shuhei , Miyata Hiroaki , Pfister Tomas 
Published: October 2021

AbstractThe COVID-19 pandemic has highlighted the global need for reliable models of disease spread. We propose an AI-augmented forecast modeling framework that provides daily predictions of the expected number of confirmed COVID-19 deaths, cases, and hospitalizations during the following 4 weeks. We present an international, prospective evaluation of our models’ performance across all states and counties in the USA and prefectures in Japan. Nationally, incident mean absolute percentage error (MAPE) for predicting COVID-19 associated deaths during prospective deployment remained consistently <8% (US) and <29% (Japan), while cumulative MAPE remained <2% (US) and <10% (Japan). We show that our models perform well even during periods of considerable change in population behavior, and are robust to demographic differences across different geographic locations. We further demonstrate that our framework provides meaningful explanatory insights with the models accurately adapting to local and national policy interventions. Our framework enables counterfactual simulations, which indicate continuing Non-Pharmaceutical Interventions alongside vaccinations is essential for faster recovery from the pandemic, delaying the application of interventions has a detrimental effect, and allow exploration of the consequences of different vaccination strategies. The COVID-19 pandemic remains a global emergency. In the face of substantial challenges ahead, the approach presented here has the potential to inform critical decisions.
ZIF-67-derived NiCo2O4@Co2P/Ni2P honeycomb nanosheets on carbon cloth for high-performance asymmetric supercapacitors
Authors: Song Wen-wei , Wang Bing , Cao Xiao-man , Chen Qiang , Han Zheng-bo 
Published: October 2021

NiCo2O4@Co2P/Ni2P-CC, for the first time, was prepared using ZIF-67 as sacrificial templates through 4 steps procedure. Based on honeycomb structures, NiCo2O4@Co2P/Ni2P-CC electrode shows high areal capacitance and excellent cycle stability.
A sequential roadmap to Industry 6.0: Exploring future manufacturing trends
Authors: Duggal Angel Swastik , Malik Praveen Kumar , Gehlot Anita , Singh Rajesh , Gaba Gurjot Singh , Masud Mehedi , Al‐Amri Jehad F. 
Published: October 2021

AbstractIt has been speculated that by the year 2050, technology will have progressed to the point of complete autonomy. This paper scrolls through patent pathways and intellectual developments throughout the industrial revolutions listing significant products and services that landmarked each revolution up to Industry 4.0. The patent trails and the recent IPR inputs are expected to assist readers in fast‐tracking up to speed on the bleeding edge of the current research pools while having an eagle's eye perspective on the previous developments so far. The research pools of Industry 4.0 are classified and explored. A lack of Human‐machine workforce synergy in Industry 4.0 and the nascent “customized manufacturing” concept is addressed in subsequent sections. The paper classifies two expected phases of Industry 5.0, highlighting the subdomains touted to be its focal areas. Lastly, Industry 5.0's niche research areas are checked and a suitable pathway to achieve the goals set for the sixth revolution is proposed.
Millimetre wave coarse beamforming using outband sub‐6 GHz reconfigurable antennas
Authors: Bshara Oday , Pano Vasil , Tajin Md Abu Saleh , Dandekar Kapil R. 
Published: October 2021

AbstractLow latency beamforming using phased antenna arrays is the key for practical deployment of envisioned millimetre wave (mmWave) Gbps mobile networks. This work aims towards reducing the overhead of the exhaustive sector‐level sweep phase of the analog beamforming adopted in the IEEE 802.11ad standard. This work is the first to propose the use of reconfigurable antenna single RF chain in the sub‐6 GHz new radio (NR) band to aid codebook‐based beam selection in the mmWave band of the NR. We exploit the congruence between the spatial propagation signatures of signals at both mmWave and sub‐6 GHz frequencies to reduce the beam search space. The simulation results show a significant reduction in mmWave beam search overhead up to on average and with an average gain loss of 3dB.
Tausendgüldenkraut: pflanzlicher Appetitanreger
Authors: Houben Martina 
Published: October 2021

SummaryTausendgüldenkraut kam bereits im Mittelalter zu Einsatz, um eine Vielzahl an Beschwerden zu heilen –heute werden Tees und Tinkturen aus dieser Heilpflanze angewandt, um den Appetit anzuregen und Magen-Darm-Symptome zu lindern
Abrechnungsempfehlung Osteopathische Medizin
Authors: Dräger Kilian 
Published: October 2021

SummaryDie Osteopathische Medizin (OM) ist eine medizinische Fachrichtung, welche seit 1874 in den USA existiert und an Universitäten zu studieren ist. In Deutschland hat sie jedoch erst in den späten 1980er Jahren wesentlichen Einzug als Fachrichtung gefunden.
Abrechnungsempfehlung Anthroposophische Medizin
Authors: Geyer Ulrich 
Published: October 2021

SummaryDie Anthroposophische Medizin (AM) gehört zu den Therapieverfahren der Besonderen Therapierichtungen. Sie wurde vor 100 Jahren von der Ärztin Dr. med. Ita Wegman und Dr. phil. Rudolf Steiner, dem Begründer der Anthroposophie, entwickelt.
Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques
Authors: Searle Amy K. , Chen Yung-Chih , Wallert Maria , Wang Xiaowei , Hosseini Hamid , Peter Karlheinz , McFadyen James D. , Maluenda Ana C. , Noonan Jonathan , Kanellakis Peter , Zaldivia Maria T. K. , Huang Angela , Lioe Hadi , Biondo Mark , Nolte Marc W. , Rossato Paolo , Bobik Alex , Panousis Con 
Published: October 2021

Background 3F7 is a monoclonal antibody targeting the enzymatic pocket of activated factor XII (FXIIa), thereby inhibiting its catalytic activity. Given the emerging role of FXIIa in promoting thromboinflammation, along with its apparent redundancy for hemostasis, the selective inhibition of FXIIa represents a novel and highly attractive approach targeting pathogenic processes that cause thromboinflammation-driven cardiovascular diseases.
Methods The effects of FXIIa inhibition were investigated using three distinct mouse models of cardiovascular disease—angiotensin II-induced abdominal aortic aneurysm (AAA), an ApoE−/− model of atherosclerosis, and a tandem stenosis model of atherosclerotic plaque instability. 3F7 or its isotype control, BM4, was administered to mice (10 mg/kg) on alternate days for 4 to 8 weeks, depending on the experimental model. Mice were examined for the development and size of AAAs, or the burden and instability of atherosclerosis and associated markers of inflammation.
Results Inhibition of FXIIa resulted in a reduced incidence of larger AAAs, with less acute aortic ruptures and an associated fibro-protective phenotype. FXIIa inhibition also decreased stable atherosclerotic plaque burden and achieved plaque stabilization associated with increased deposition of fibrous structures, a >2-fold thicker fibrous cap, increased cap-to-core ratio, and reduction in localized and systemic inflammatory markers.
Conclusion Inhibition of FXIIa attenuates disease severity across three mouse models of thromboinflammation-driven cardiovascular diseases. Specifically, the FXIIa-inhibiting monoclonal antibody 3F7 reduces AAA severity, inhibits the development of atherosclerosis, and stabilizes vulnerable plaques. Ultimately, clinical trials in patients with cardiovascular diseases such as AAA and atherosclerosis are warranted to demonstrate the therapeutic potential of FXIIa inhibition.
Congenital Anatomical Variant with Cranial Origin of Internal Iliac Arteries
Authors: Rossi Umberto G. , Ierardi Anna M. , Cariati Maurizio 
Published: October 2021

AbstractWe report the case of a 73-year-old male who underwent abdominal multidetector computed tomography with vascular reconstruction that highlighted a congenital variant of iliac arteries. Iliac artery anatomical variants are exceedingly rare and only a few cases have been reported in the literature.
Perceval Implantation and Ascending Replacement: Which Should Be Performed First?
Authors: Santarpino Giuseppe , Specchia Luigi , Mastroroberto Pasquale , Gregorini Renato 
Published: October 2021

AbstractThe use of sutureless prostheses has expanded due to their ability to reduce surgical times, thus favoring their implantation in high-risk patients. It is not uncommon that these patients have an ascending aortic aneurysm requiring treatment with a vascular prosthesis; therefore, using a sutureless aortic valve may be associated. To date, however, little is known about the time sequence of this intervention, that is, if sutureless implantation should precede or follow that of the vascular prosthesis.
Contemporary Management of Zygomaticomaxillary Complex Fractures
Authors: Wang Howard D. , Dillon Jasjit 
Published: October 2021

AbstractZygomaticomaxillary complex fracture is one of the most commonly treated facial fractures. Accurate reduction and stable fixation of the zygoma are required to restore facial symmetry and projection and avoid functional sequalae from changes in orbital volume. Achieving optimal outcome is challenging due to the complex three-dimensional anatomy and limited visualization of all affected articulations of the zygoma. This article provides an updated overview of the evaluation and management of zygomaticomaxillary complex fractures based on available evidence and clinical experience at our center. The importance of soft tissue management is emphasized, and approaches to internal orbital reconstruction are discussed. While evidence remain limited, intraoperative imaging and navigation may prove to be useful adjuncts in the treatment of zygomaticomaxillary fractures.
Structure evolution of hBN grown on molten Cu by regulating precursor flux during chemical vapor deposition
Authors: Liu Hongwei , He Wanzhen , Liu Zhenjing , Abidi Irfan H , Ding Yao , Galligan Patrick Ryan , Tamtaji Mohsen , Li Jingwei , Cai Yuting , Kang Ting , Wong Hoilun , Li Zhongjian , Zhao Pei , Gao Zhaoli , Mi Yongli , Xu Zhiping , Luo Zhengtang 
Published: October 2021

Abstract
We demonstrate the structure evolution of hexagonal boron nitride (hBN) flakes grown on molten Cu in atmospheric pressure chemical vapor deposition by regulating the flux of precursor. We found that under lower precursor flux, tuned by temperature that controls the sublimation rates, the hBN grains change from triangle to truncated triangle shape with additional B-terminated edges, which could be understood through kinetic Wulff construction, while under higher flux, they form circular shape following deposition-controlled growth and predicted by a phase field modeling. In addition to the monolayer morphology from a single nucleation, adlayer patterns with centered aggregation and diffusive features at high precursor flux are observed and simulated by a two-dimensional (2D) diffusion-reaction model, where the random diffusion and deposition are revealed to be the dominating kinetics. The nucleation density and growth velocity could also be modulated by the ammonia borane heating temperature, where 80 °C is found to be optimal for the largest hBN grain size. Our transmission electron microscopy study shows that a misalignment of coalescing grains occurs on such molten Cu substrate, deviated from those observed on molten Au. Our results provide a new tool for the shape and grain size control of 2D materials and the understanding of their growth kinetics for large scale production.
Victorian Railways Commissioners v Coultas: The Untold Story
Authors: Handford Peter 
Published: October 2021

Abstract
[The story of liability for ‘nervous shock’ begins with the Privy Council decision in Victorian Railways Commissioners v Coultas in 1888 holding that such damage was too remote—a decision soon rejected by courts in England and elsewhere (though it had considerable influence in the United States). Over the next hundred years, courts gradually extended the boundaries of liability for what is now called psychiatric injury or mental harm. But the law reports tell us nothing about James and Mary Coultas, apart from what happened to them on one particular day. Moreover, the assertion in the initial report that Mary suffered a miscarriage is actually misleading, colouring judicial attitudes to nervous shock over a long period. Who were James and Mary Coultas, and why did they bring the action? What were the consequences of losing the case, and what happened to them after that? This article looks beyond the law reports to other sources in order to answer these questions.]
Facial Aesthetic Priorities and Concerns: A Physician and Patient Perception Global Survey
Authors: Fabi Sabrina , Alexiades Macrene , Chatrath Vandana , Colucci Ligia , Sherber Noëlle , Heydenrych Izolda , Jagdeo Jared , Dayan Steven , Swift Arthur , Chantrey Jonquille , Stevens W Grant , Sangha Sara 
Published: October 2021

Abstract

Background
Minimally invasive and noninvasive facial aesthetic treatments are increasingly popular, and a greater understanding of patient perspectives on facial aesthetic priorities is needed.

Objectives
The authors surveyed facial aesthetic concerns, desires, and treatment goals of aesthetically conscious men and women, and physicians, in 18 countries.

Methods
This was a global, internet-based survey on desired appearance and experiences with, or interest in, facial aesthetic treatments. Eligible respondents were aesthetically conscious adults (21-75 years). Eligible aesthetic physicians were required to see ≥30 patients per month for aesthetic reasons, have 2 to 30 years of experience in clinical practice, and spend ≥70% of their time in direct patient care.

Results
A total of 14,584 aesthetically conscious adults (mean age, 41 years; 70% women) and 1315 aesthetic physicians (mean age, 45 years; 68% men) completed the survey. Most respondents (68%) reported that aesthetic procedures should be sought in their 30s to 40s; physicians recommended patients seek treatment earlier. Respondents expressed greatest concern over crow’s feet lines, forehead lines, facial skin issues, hair-related concerns, and under-eye bags or dark circles; in contrast, physicians tended to underestimate concerns about under-eye bags or dark circles, mid-face volume deficits, and skin quality. Although both physicians and respondents cited cost as a major barrier to seeking aesthetic treatments, respondents also emphasized safety, fear of injections or procedure-related pain, and concern about unnatural-looking outcomes.

Conclusions
This global survey provides valuable insight into facial aesthetic concerns and perspectives that may be implemented in patient education and consultations to improve patient satisfaction following aesthetic treatments.
Diminished and waning immunity to COVID-19 vaccination among hemodialysis patients in Israel: the case for a third vaccine dose
Authors: Angel-Korman Avital , Peres Esther , Bryk Gabriel , Lustig Yaniv , Indenbaum Victoria , Amit Sharon , Rappoport Vladimir , Katzir Zeev , Yagil Yoram , Iaina Nomy Levin , Leiba Adi , Brosh-Nissimov Tal 
Published: October 2021

ABSTRACT

Background
Humoral responses to coronavirus disease 2019 (COVID-19) vaccines in hemodialysis (HD) patients can direct vaccination policy.

Methods
We compared 409 COVID-19-naïve HD patients from 13 HD units in Israel to 148 non-dialysis-dependent COVID-19-naïve controls. Twenty-four previously infected (antinucleocapsid positive) HD patients were analysed separately. Blood samples were obtained ≥14 days post-vaccination (BNT162b2, Pfizer/BioNTech) to assess seroconversion rates and titers of anti-spike (anti-S) and neutralizing antibodies.

Results
The median time from vaccination to blood sample collection was 82 days [interquartile range (IAR) 64–87] and 89 days (IQR 68–96) for HD patients and controls, respectively. Seroconversion rates were lower in HD patients compared with controls for both anti-S and neutralizing antibodies (89% and 77% versus 99.3%, respectively; P &lt; 0.0001). Antibody titers were also significantly lower in HD patients compared with controls {median 69.6 [IQR 33.2–120] versus 196.5 [IQR 118.5–246], P &lt; 0.0001; geometric mean titer [GMT] 23.3 [95% confidence interval (CI) 18.7–29.1] versus 222.7 [95% CI 174–284], P &lt; 0.0001, for anti-S and neutralizing antibodies, respectively}. Multivariate analysis demonstrated dialysis dependence to be strongly associated with lower antibody responses and antibody titers waning with time. Age, low serum albumin and low lymphocyte count were also associated with lower seroconversion rates and antibody titers. HD patients previously infected with sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had no difference in their seroconversion rates or antibody titers compared with COVID-19-naïve patients.

Conclusion
This study demonstrates diminished and waning humoral responses following COVID-19 vaccination in a large and diverse cohort of HD patients, including those previously infected with SARS-CoV-2. Considering these results and reduced vaccine effectiveness against variants of concern, in addition to continued social distancing precautions, a third booster dose should be considered in this population.