bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Outcomes in Codon 12/13 and Codon 61NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients withNRAS-Mutated Tumors
Authors: Cleary James M. , Wang Victoria , Heist Rebecca S. , Kopetz E. Scott , Mitchell Edith P. , Zwiebel James A. , Kapner Kevin S. , Chen Helen X. , Li Shuli , Gray Robert J. , McShane Lisa M. , Rubinstein Larry V. , Patton David R. , Meric-Bernstam Funda , Dillmon Melissa S. , Williams P. Mickey , Hamilton Stanley R. , Conley Barbara A. , Aguirre Andrew J. , O'Dwyer Peter J. , Harris Lyndsay N. , Arteaga Carlos L. , Chen Alice P. , Flaherty Keith T. 
Published: February 2021

AbstractPurpose:Preclinical and clinical data suggest that downstream inhibition with an MEK inhibitor, such as binimetinib, might be efficacious for NRAS-mutated cancers.Patients and Methods:Patients enrolled in the NCI-MATCH trial master protocol underwent tumor biopsy and molecular profiling by targeted next-generation sequencing. Patients with NRAS-mutated tumors, except melanoma, were enrolled in subprotocol Z1A, a single-arm study evaluating binimetinib 45 mg twice daily. The primary endpoint was objective response rate (ORR). Secondary endpoints included progression-free survival (PFS) and overall survival (OS). A post hoc analysis examined the association of NRAS mutation type with outcome.Results:In total, 47 eligible patients with a refractory solid tumor harboring a codon 12, 13, or 61 NRAS mutation were treated. Observed toxicity was moderate, and 30% of patients discontinued treatment because of binimetinib-associated toxicity. The ORR was 2.1% (1/47 patients). A patient with malignant ameloblastoma harboring a codon 61 NRAS mutation achieved a durable partial response (PR). A patient with NRAS codon 61–mutated colorectal cancer had an unconfirmed PR, and two other patients with NRAS codon 61–mutated colorectal had stable disease for at least 12 months. In an exploratory analysis, patients with colorectal cancer bearing a NRAS codon 61 mutation (n = 8) had a significantly longer OS (P = 0.03) and PFS (P = 0.007) than those with codon 12 or 13 mutations (n = 16).Conclusions:Single-agent binimetinib did not show promising efficacy in NRAS-mutated cancers. The observation of increased OS and PFS in patients with codon 61 NRAS-mutated colorectal cancer merits further investigation.
Observations on the flowering plant diversity of Madayippara, a southern Indian lateritic plateau from Kerala, India
Authors: Pramod C. , Pradeep A.K. 
Published: February 2021

Northern Kerala of southern India is characterized by widely spread lateritic plateaus which provide an extremely harsh physical environment for life leading to the development of specialized plant communities with a large number of endemic and habitat specific species. Madayippara, a midland lateritic plateau located in the Kannur District of northern Kerala is an icon of rich floristic diversity and endemism. The plateau forms a number of microhabitats due to the difference in geographic terrain and soil cover, thus forming a complex of habitats with diverse forms of plants, mainly ephemeral herbs. Out of the 636 flowering plant taxa recorded from the microhabitats of the plateau, within a limited area of 3.65km2, 160 (c. 25%) are endemics. Most of the endemic species occur in specialized microhabitats. The plateau is the type locality of 11 taxa. Lateritic plateaus of southern India, which are associated with characteristic and rich biodiversity, are now under varied types of anthropogenic threats such as large scale mining for bricks and clay, and they need urgent attention for conservation of the biodiversity.
Some biological aspects of the central Indian endemic scorpion Hottentotta jabalpurensis Kovařík, 2007 (Scorpiones: Buthidae)
Authors: Pandey Pragya , Mohapatra Pratyush P. , Bastawade D.B. 
Published: February 2021

The present study reports the distribution and bionomics of Hottentotta jabalpurensis Kovarik, 2007, a central India endemic species. Information on courtship, maternal care, feeding habits, and kin recognition has been provided based on observations made in captivity. Morphological and morphometric details of the pre-insemination spermatophore of the species have been detailed for the first time for the species.
Herpetofaunal inventory of Van Province, eastern Anatolia, Turkey
Authors: Yıldız Mehmet Zülfü , İğci Naşit , Akman Bahadır 
Published: February 2021

In this study, amphibian and reptile diversity in the province of Van (eastern Anatolia, Turkey) was surveyed. For this purpose, four herpetological excursions (20 days in total) were conducted covering all the districts of the province in 2014. In this paper, up-to-date herpetofaunal inventory of Van Province, including two urodelian, four anuran, two chelonian, 15 saurian (lizards), and 14 ophidian (snakes) species (six amphibians and 31 reptiles in total) is presented. To the best of our knowledge, Salamandra infraimmaculata, Heremites auratus, Dolichophis jugularis, Eirenis modestus, and Telescopus fallax were recorded for the first time in the province of Van. Additionally, the first published print record of Stellagama stellio in Van Province is presented. The major threat to the herpetofaunal diversity in surveyed habitats was found as human-origin habitat degradation. With the georeference database obtained in this study, it will be possible to determine the actual distribution ranges of the species and to guide decision-makers. The results of the study will provide a useful basis for future monitoring studies and distribution information will contribute to the conservation of the species of interest.
Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence
Authors: Raub Dana , Platzbecker Katharina , Grabitz Stephanie D. , Xu Xinling , Wongtangman Karuna , Pham Stephanie B. , Murugappan Kadhiresan R. , Hanafy Khalid A. , Nozari Ala , Houle Timothy T. , Kendale Samir M. , Eikermann Matthias 
Published: February 2021

Background
Preclinical studies suggest that volatile anesthetics decrease infarct volume and improve the outcome of ischemic stroke. This study aims to determine their effect during noncardiac surgery on postoperative ischemic stroke incidence.

Methods and Results

This was a retrospective cohort study of surgical patients undergoing general anesthesia at 2 tertiary care centers in Boston, MA, between October 2005 and September 2017. Exclusion criteria comprised brain death, age <18 years, cardiac surgery, and missing covariate data. The exposure was defined as median age‐adjusted minimum alveolar concentration of all intraoperative measurements of desflurane, sevoflurane, and isoflurane. The primary outcome was postoperative ischemic stroke within 30 days. Among 314 932 patients, 1957 (0.6%) experienced the primary outcome. Higher doses of volatile anesthetics had a protective effect on postoperative ischemic stroke incidence (adjusted odds ratio per 1 minimum alveolar concentration increase 0.49, 95% CI, 0.40–0.59,
P
<0.001). In Cox proportional hazards regression, the effect was observed for 17 postoperative days (postoperative day 1: hazard ratio (HR), 0.56; 95% CI, 0.48–0.65; versus day 17: HR, 0.85; 95% CI, 0.74–0.99). Volatile anesthetics were also associated with lower stroke severity: Every 1‐unit increase in minimum alveolar concentration was associated with a 0.006‐unit decrease in the National Institutes of Health Stroke Scale (95% CI, −0.01 to −0.002,
P
=0.002). The effects were robust throughout various sensitivity analyses including adjustment for anesthesia providers as random effect.

Conclusions
Among patients undergoing noncardiac surgery, volatile anesthetics showed a dose‐dependent protective effect on the incidence and severity of early postoperative ischemic stroke.
Wearing the Cosmos: The High Priestly Attire in Josephus’ Judean Antiquities
Authors: Pena Joabson Xavier 
Published: February 2021

Abstract
In his recounting of the Exodus narrative of the making of the priestly vestments in Judean Antiquities 3.151-180, 184-187, Josephus provides a vivid description of the high priest’s wardrobe, including its cosmological connotations. This article shows that Josephus uses cosmological motifs in his recounting of the high priestly attire in order to convey a message to his intended audience in Rome. Josephus adds his own accents to the biblical narrative to convince his public that the high priest’s fine clothing functions as a statement that the Judean God is not a national deity with restricted power, but the Highest God, who is the only creator, maintainer, and supreme ruler of the universe. Seen from this perspective, we observe Josephus in dialogue with a well-established Greco-Roman clothing imagery tradition that portrays gods and mortals in symbolic garments to enhance their far-reaching power or authority.
Identification of mahogany sliced veneer using handheld near-infrared spectroscopy device and multivariate data analysis
Authors: Rocha Hugo S. , Braga Jez W.B. , Kunze Daniele C.G.C. , Coradin Vera T.R. , Pastore Tereza C.M. 
Published: February 2021

Abstract
The illegal logging of valuable tree species is mainly motivated by a global market that consumes logs, lumber, veneers, and furniture. The use of objective techniques to identify species and the effects of international initiatives such as CITES rules contributes to controlling trade, exploitation, and smuggling of these products. The anatomical identification of wood veneers is limited due to the loss of several anatomical characters in the production process of the veneers. For this reason, we propose the Near-Infrared Spectroscopy technique associated with chemometric tools for the discrimination of wood veneer of woods with similar general characters: Swietenia macrophylla King (mahogany), Carapa guianensis Aubl. (andiroba), Cedrela odorata L. (cedro), Micropholis venulosa Pierre (curupixá), and Hymenaea coubaril L. (jatobá) using a portable spectrometer.The development of the discrimination models was performed using the PLS-DA (Partial Least Squares for Discriminant Analysis) algorithm. The detection and subsequent exclusion of outliers were performed based on Hotelling T2, Q residuals, and errors in estimating class values. The PLS-DA models showed an efficiency between 96.5% and 100% in the samples’ discrimination among the five forest species. In conclusion, the portable NIRS technology and the PLS-DA models were suitable for the rapid identification and discrimination of the wood veneers.
Re-description and systematic re-appraisal of the genus Kokkocynips Pujade-Villar &amp; Melika, (Hymenoptera: Cynipidae: Cynipini), including new combinations of Nearctic species and the description of a new species from Panama
Authors: NIEVES-ALDREY JOSÉ LUIS , NICHOLLS JAMES A. , TANG CHANG-TI , MELIKA GEORGE , STONE GRAHAM N. , PUJADE-VILLAR JULI , BUFFINGTON MATTHEW , MALDONADO YURIXI , MEDIANERO ENRIQUE 
Published: February 2021

The monophyly and taxonomic validity of some currently accepted genera of gall wasps in the Cynipini (Hymenoptera: Cynipidae) are being challenged by recent systematic studies. Here we used morphological and molecular data to re-describe and revise the taxonomic limits of the monotypic genus Kokkocynips Pujade-Villar & Melika, previously recorded only from Mexico. We describe a new species from Panama, Kokkocynips panamensis Medianero & Nieves-Aldrey, reared from galls on Quercus salicifolia Neé, and add new records from Mexico for the type species of the genus K. doctorrosae Pujade-Villar. Six Nearctic species, Dryocosmus rileyi (Ashmead, 1896), D. imbricariae (Ashmead, 1896), D. coxii (Basset, 1881), D. deciduus (Beutenmueller, 1913), Callirhytis difficilis (Ashmead, 1887) and C. attractans (Kinsey, 1922) are transferred to Kokkocynips. Species of Kokkocynips are associated only with red oaks (Quercus section Lobatae (Fagaceae)) and are distributed in the Nearctic and Neotropical regions, from Canada through Mexico and Panama. Taxonomic limits of Kokkocynips are discussed in light of the molecular phylogenetic relationships of the studied species. Diagnostic characters, gall description, distribution, and biological data of Kokkocynips species are given, including a key for the identification of the asexual generations of seven species.
Damage Control Laparotomy in the Cirrhotic Trauma Patient is Highly Lethal: A Matched Cohort Study
Authors: Jakob Dominik A. , Benjamin Elizabeth R. , Lewis Meghan , Liasidis Panagiotis , Demetriades Demetrios 
Published: February 2021

IntroductionDamage control laparotomy (DCL) has revolutionized trauma care and is considered the standard of care for severely injured patients requiring laparotomy. The role of DCL in cirrhotic patients has not been investigated.MethodsA matched cohort study using American College of Surgeons Trauma Quality Improvement Program database including patients undergoing DCL within 24 hours of admission. A 1:2 cohort matching of cirrhotic vs. non-cirrhotic patients was matched for the following criteria: age (>55, ≤55 years), gender, mechanism of injury (blunt and penetrating), injury severity score (ISS) (≤25, >25), head/face/neck Abbreviated Injury Scale (AIS) (<3, ≥3), chest AIS (<3, ≥3), abdominal AIS (<3, ≥3), and overall comorbidities. Outcomes between the 2 cohorts were subsequently compared with univariable analysis.ResultsOverall, 1151 patients with DCL within 24 hours were identified, 29 (2.5%) with liver cirrhosis. Six cirrhotic patients were excluded because there were no suitable matching controls. The remaining 23 cirrhotic patients were matched with 46 non-cirrhotic patients. Overall mortality in the cirrhotic group was 65% vs. 26% in the non-cirrhotic group ( P = .002). The higher mortality rate in cirrhotic vs. non-cirrhotic patients was accentuated in the group with ISS >25 (83% vs. 33%; P = .005). 40% of the deaths in cirrhotic patients occurred after 10 days of admission, compared to only 8% in non-cirrhotic patients ( P = .091). The total blood product use within 24 hours was significantly higher in cirrhotic than non-cirrhotic patients [33 (14-46) units vs. 19.9 (4-32) units; P = .044].ConclusionCirrhotic trauma patients undergoing DCL have a very high mortality. A significant number of deaths occur late and alternative methods of physiological support should be considered.
Trans-nasal high-flow dehumidified air in acute migraine headaches: A randomized controlled trial
Authors: Shah Rushil , Assis Fabrizio , Narasimhan Bharat , Khachadourian Vahe , Zhou Shijie , Tandri Harikrishna , Tariq Nauman 
Published: February 2021

Background Intranasal high flow of dehumidified (dry) air results in evaporative cooling of nasal passages. In this randomized clinical trial, we investigated the effect of dry gas induced nasal cooling on migraine headaches. Methods In this single-blind study, acute migraineurs were randomized to either nasal high-flow dry oxygen, dry air, humidified oxygen or humidified air (control) at 15 L/min for 15 min. All gases were delivered at 37°C. Severity of headache and other migraine associated symptoms (International Classification for Headache Disorders, 3rd edition criteria) were recorded before and after therapy. The primary endpoint was change in pain scores, while changes in nausea, photosensitivity and sound sensitivity scores served as secondary endpoints. A linear regression model was employed to estimate the impact of individual treatment components and their individual interactions. Results Fifty-one patients (48 ± 15 years of age, 82% women) were enrolled. When compared to the control arm (humidified air), all therapeutic arms showed a significantly greater reduction in pain scores (primary endpoint) at 2 h of therapy with dry oxygen (−1.6 [95% CI −2.3, −0.9]), dry air (−1.7 [95% CI −2.6, −0.7)]), and humidified oxygen (−2.3 [95% CI −3.5, −1.1]). A significantly greater reduction in 2-h photosensitivity scores was also noted in all therapeutic arms (−1.8 [95% CI −3.2, −0.4], dry oxygen; −1.7 [95% CI −2.9, −0.4], dry air; (−2.1 [95% CI −3.6, −0.6], humidified oxygen) as compared to controls. The presence of oxygen and dryness were independently associated with significant reductions in pain and photosensitivity scores. No adverse events were reported. Conclusion Trans-nasal high-flow dry gas therapy may have a role in reducing migraine associated pain. Clinical Trial registration: NCT04129567
Premonitory symptoms in migraine from China: A multi-clinic study of 4821 patients
Authors: Wang Xiaolin , Yin Ziming , Lian Yajun , Xu Yanmei , Li Yajie , Liu Jiale , Gu Qun , Yan Fanhong , Ge Zhaoli , Lian Yu , Hu Dongmei , Chen Sufen , Wang Rongfei , Chen Xiaoyan , Liu Jing , Zhang Mingjie , Ran Ye , Zhou Ping , Ma Jingyi , Lv Xudong , Dong Zhao , Yu Shengyuan 
Published: February 2021

Objective To observe the prevalence and characteristics of premonitory symptoms in Chinese migraineurs and explore their associations with migraine-related factors. Method Migraineurs who visited a tertiary headache clinic and one of nine neurology clinics between May 2014 and November 2019 were studied. Result Among the 4821 patients meeting the migraine criteria (International Classification of Headache Disorders, 3rd edition), 1038 (21.5%) patients experienced at least one premonitory symptom. The most common premonitory symptoms were neck stiffness, dizziness, yawning and drowsiness. The logistic regression analysis demonstrated that aura, photophobia, aggravation by routine physical activity, triggers, family history, depression, coffee consumption and physical exercise were associated with an increased probability of experiencing premonitory symptoms ( p ≤ 0.001). The premonitory symptoms of migraine with and without aura differ in prevalence and most common symptoms. The cluster analysis revealed pairwise clustering of the following premonitory symptoms: Photophobia/phonophobia, concentration change/dysesthesia, loquacity/overactivity, yawning/drowsiness, fatigue/dizziness, and mood change/irritability. The correlation analysis of triggers and premonitory symptoms revealed that temperature change, environment change, sleep disorder, activity and stress were related to multiple premonitory symptoms, and that food, light, menstruation, alcohol and odor were related to special premonitory symptoms ( p ≤ 0.001). Conclusion The prevalence of premonitory symptoms among migraineurs in China is 21.5%. Some factors influence the probability of experiencing premonitory symptoms. Paired premonitory symptoms in the clustering analysis may share similar origins. Certain triggers associated with multiple premonitory symptoms may induce brain dysfunction; however, other triggers that overlap with corresponding special premonitory symptoms may be premonitory symptoms or a form of premonitory symptom.
Numerical investigation of wing–wing interaction and its effect on the aerodynamic force of a hovering dragonfly
Authors: Swain Prafulla Kumar , Dora Siva Prasad , Battula Suryanarayana Murthy , Barik Ashok K 
Published: February 2021

The present research focuses on the timing of wing–wing interaction that benefits the aerodynamic force of a dragonfly in hovering flight at Reynolds number 1350. A 3-D numerical simulation method, called the system coupling, was utilised by implementing a two-way coupling between the transient structural and flow analysis. We further explore the aerodynamic forces produced at different phase angles on the forewing and hindwing during the hovering flight condition of a dragonfly. A pair of dragonfly wings is simulated to obtain the force generated during flapping at a 60° inclination stroke plane angle with respect to the horizontal. The hovering flight is simulated by varying the phase angle and the inter-distance between the two wings. We observe a significant enhancement in the lift (16%) of the hindwing when it flaps in-phase with the forewing and closer to the forewing, maintaining an inter-wing distance of 1.2 cm (where cm is the mean chord length). However, for the same condition, the lift of the hindwing reduces by 9% when the wings are out of phase/counterstroke flapping. These benefits and drawbacks are dependent on the timing of the interactions between the forewing and hindwing. The time of interaction of wake capture, wing–wing interaction, dipole structure and development of root vortex are examined by 2-D vorticity of the flow field and isosurface of the 3-D model dragonfly. From the isosurface, we found that the root vortex elicited at the root of the hindwing in counter-flapping creates an obstacle for the shedding of wake vortices, which results in reduction of vertical lift during the upstroke of flapping. Hence, at the supination stage, a dragonfly uses a high rotation angle for the hovering flight mode. It is observed that the system coupling method was found to be more efficient and exhibited better performance. The present numerical methodology shows a very close match to the previously reported results.
A Systematic Review of Efficacy and Safety of Monotherapy and Combination Therapy With Biologic for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Authors: Sachdeva Muskaan , Maliyar Khalad , Ponzo Marisa G. 
Published: February 2021

Background Biologic drugs have the potential to halt the progression of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) by decreasing concentrations of tumor necrosis factor-α, a cytokine implicated in epithelial cell death. The objective of this systematic review is to investigate the efficacy and safety of biologic monotherapy and combination therapy for SJS/TEN. Methods MEDLINE and EMBASE in OVID were searched on October 28, 2020. Inclusion criteria were original studies containing human participants diagnosed with SJS/TEN and treated with biologics. Studies were excluded if they were literature reviews, systematic reviews, letters to the editor, or conference abstracts. Results The 38 articles reviewed included 27 (71.1%) case reports, 6 (15.8%) case series, 3 (7.9%) retrospective reviews, and 2 (5.3%) RCTs. The age range of the included studies was 2 to 85 years, the mean age was 46.4 years. The mean body surface (BSA) across the 38 included articles was 31.0%. The average actual mortality reported within the 38 included articles was 9.2%. Both biologic monotherapy and combination therapy were associated with improved outcomes in SJS/TEN. Furthermore, anti TNF-alpha therapy, specifically etanercept, showed improved outcomes as monotherapy. Conclusions Overall, reviewed studies presented a strong case for biologic treatment, both monotherapy and combination use, in SJS/TEN treatment. Based on the number of fatal adverse events observed, biologic monotherapy may be safer compared to combination therapy. Further research with a larger sample size and a randomized control trial design is required.