bluuebunny/crossref_metadata_2025_split huggingface dataset:
The levels of soluble cMET ectodomain in the blood of patients with ovarian cancer are an independent prognostic biomarker
Authors: Klotz Daniel Martin , Link Theresa , Goeckenjan Maren , Wimberger Pauline , Kuhlmann Jan Dominik 
Published: March 2021

The tyrosine kinase mesenchymal–epithelial transition (cMET) is typically overexpressed in up to 75% of patients with ovarian cancer, and cMET overexpression has been associated with poor prognosis. The proteolytic release of the soluble cMET (sMET) ectodomain by metalloproteases, a process called ectodomain shedding, reflects the malignant potential of tumour cells. sMET can be detected in the human circulation and has been proposed as biomarker in several cancers. However, the clinical relevance of sMET in ovarian cancer as blood‐based biomarker is unknown and was therefore investigated in this study. sMET levels were determined by enzyme‐linked immunosorbent assay in a set of 432 serum samples from 85 healthy controls and 86 patients with ovarian cancer (87% FIGO III/IV). Samples were collected at primary diagnosis, at four longitudinal follow‐up time points during the course of treatment and at disease recurrence. Although there was no significant difference between median sMET levels at primary diagnosis of ovarian cancervs. healthy controls, increased sMET levels at primary diagnosis were an independent predictor of shorter PFS (HR = 0.354, 95% CI: 0.130–0.968,P = 0.043) and shorter OS (HR = 0.217, 95% CI: 0.064–0.734,P = 0.014). In the follow‐up samples, sMET levels were prognostically most informative after the first three cycles of chemotherapy, with high sMET levels being an independent predictor of shorter PFS (HR = 0.245, 95% CI: 0.100–0.602,P = 0.002). This is the first study to suggest that sMET levels in the blood can be used as an independent prognostic biomarker for ovarian cancer. Patients at high risk of recurrence and with poor prognosis, as identified based on sMET levels in the blood, could potentially benefit from cMET‐directed therapies or other targeted regimes, such as PARP inhibitors or immunotherapy.
CoPSe: A New Ternary Anode Material for Stable and High‐Rate Sodium/Potassium‐Ion Batteries
Authors: Feng Yutong , Xu Mengzhu , He Ting , Chen Bingjie , Gu Feng , Zu Lianhai , Meng Ruijin , Yang Jinhu 
Published: March 2021

AbstractThe exploration of ideal electrode materials overcoming the critical problems of large electrode volume changes and sluggish redox kinetics induced by large ionic radius of Na+/K+ ions is highly desirable for sodium/potassium‐ion batteries (SIBs/PIBs) toward large‐scale applications. The present work demonstrates that single‐phase ternary cobalt phosphoselenide (CoPSe) in the form of nanoparticles embedded in a layered metal–organic framework (MOF)‐derived N‐doped carbon matrix (CoPSe/NC) represents an ultrastable and high‐rate anode material for SIBs/PIBs. The CoPSe/NC is fabricated by using the MOF as both a template and precursor, coupled with in situ synchronous phosphorization/selenization reactions. The CoPSe anode holds a set of intrinsic merits such as lower mechanical stress, enhanced reaction kinetics, as well as higher theoretical capacity and lower discharge voltage relative to its counterpart of CoSe2, and suppressed shuttle effect with higher intrinsic electrical conductivity relative to CoPS. The involved mechanisms are evidenced by substantial characterizations and density functional theory (DFT) calculations. Consequently, the CoPSe/NC anode shows an outstanding long‐cycle stability and rate performance for SIBs and PIBs. Moreover, the CoPSe/NC‐based Na‐ion full cell can achieve a higher energy density of 274 Wh kg−1, surpassing that based on CoSe2/NC and most state‐of‐the‐art Na‐ion full cells based on P‐, Se‐, or S‐containing binary/ternary anodes to date.
Rib Stitch Knitted Extremely Stretchable and Washable Textile Triboelectric Nanogenerator
Authors: Rezaei Javid , Nikfarjam Alireza 
Published: March 2021

AbstractIn recent years with developing wearable technologies, one of the challenges is energy consumption. Rechargeable or removable batteries are incompatible with wearable applications. Because the batteries are not flexible, foldable, stretchable, lightweight, and require substitutes or charges. Consequently, the best choice is self‐charging systems. The extremely stretchable and washable textile triboelectric nanogenerator (T‐TENG) is designed and fabricated in this work. It is knitted with a rib stitch technique by double twisted thread‐based. Subsequently, the rib stitch method is chosen to achieve the most stretchability and flexibility in this textile by investigating the knitting techniques. Likewise, the active triboelectric materials are polyvinyl chloride and polyamide 6. The maximum instantaneous peak power density is ≈18 mW m‐2 and the measured output voltage and current are 29.2 V and 5.3 μA, respectively. Following this, the experimental test report on the index finger, the relationship between textile tension and voltage production, and the resulting wash and durability tests are provided. This work successfully demonstrates T‐TENG quite compatible with self‐power wearable applications, which can harvest energy from the ambient mechanical tensions and capable of supply power for low power systems in wearable electronics.
Borata‐Alkene Species as Nucleophilic Reservoir
Authors: Maza Ricardo J. , Carbó Jorge J. , Fernández Elena 
Published: March 2021

Abstractα‐Monoboryl anions show remarkable stability due to the valence deficiency of the adjacent three‐coordinate boron center and can be expressed as its resonance form, the borata‐alkene systems [R2B=CH2]−. The diversity of synthetic approaches as well as the properties of the C=B bond are disclosed in this review, dealing with both electronic and structural properties of the boryl moieties involved. Full characterization in solid state by X‐ray diffraction demonstrated the short distances between B and C, as a consequence of the boron ylide character in the boron‐stabilized carbanions. This review includes a collection of C−B length distances as well as 11B NMR data that can be useful for diagnostic evidence of the partial boron‐carbon double‐bond character. Natural bond orbital (NBO) analysis on DFT computed structures also supports and justifies the borata‐alkene character.The reactivity of the C=B bond acting as nucleophilic synthon is unveiled through extensive electrophilic trapping examples. The homologation protocols with diborylmethane, via single carbon chain extension, involves a facile introduction of the C(sp3)−B bonds, which can be subsequently transformed into functionalized target products, containing C−O, C−N or C−C bonds.magnified image
The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics
Authors: McGlynn Eve , Nabaei Vahid , Ren Elisa , Galeote‐Checa Gabriel , Das Rupam , Curia Giulia , Heidari Hadi 
Published: March 2021

AbstractNeurological diseases are a prevalent cause of global mortality and are of growing concern when considering an ageing global population. Traditional treatments are accompanied by serious side effects including repeated treatment sessions, invasive surgeries, or infections. For example, in the case of deep brain stimulation, large, stiff, and battery powered neural probes recruit thousands of neurons with each pulse, and can invoke a vigorous immune response. This paper presents challenges in engineering and neuroscience in developing miniaturized and biointegrated alternatives, in the form of microelectrode probes. Progress in design and topology of neural implants has shifted the goal post toward highly specific recording and stimulation, targeting small groups of neurons and reducing the foreign body response with biomimetic design principles. Implantable device design recommendations, fabrication techniques, and clinical evaluation of the impact flexible, integrated probes will have on the treatment of neurological disorders are provided in this report. The choice of biocompatible material dictates fabrication techniques as novel methods reduce the complexity of manufacture. Wireless power, the final hurdle to truly implantable neural interfaces, is discussed. These aspects are the driving force behind continued research: significant breakthroughs in any one of these areas will revolutionize the treatment of neurological disorders.
Interface Optimization via Fullerene Blends Enables Open‐Circuit Voltages of 1.35 V in CH3NH3Pb(I0.8Br0.2)3 Solar Cells
Authors: Liu Zhifa , Siekmann Johanna , Klingebiel Benjamin , Rau Uwe , Kirchartz Thomas 
Published: March 2021

AbstractNonradiative recombination processes are the biggest hindrance to approaching the radiative limit of the open‐circuit voltage for wide bandgap perovskite solar cells. In addition to high bulk quality, good interfaces and good energy level alignment for majority carriers at charge transport layer‐absorber interfaces are crucial to minimize nonradiative recombination pathways. By tuning the lowest‐unoccupied molecular‐orbital of electron transport layers via the use of different fullerenes and fullerene blends, open‐circuit voltages exceeding 1.35 V in CH3NH3Pb(I0.8Br0.2)3 device are demonstrated. Further optimization of mobility in binary fullerenes electron transport layers can boost the power conversion efficiency as high as 18.9%. It is noted in particular that the Voc fill factor product is >1.096 V, which is the highest value reported for halide perovskites with this bandgap.
A Growing Appreciation for the Role of LiF in the Solid Electrolyte Interphase
Authors: Tan Jian , Matz John , Dong Pei , Shen Jianfeng , Ye Mingxin 
Published: March 2021

AbstractRechargeable lithium batteries (RLBs) have revolutionized energy storage technology. However, short lifetime and safety issues have hampered their further commercialization, which is mainly attributable to the unstable solid‐electrolyte interphase (SEI) and uncontrolled lithium dendrite growth. In recent years, research on SEI has been pursued with determination worldwide. However, the structure and composition of the SEI have long been debated. Especially, the role of the main component, LiF, remains elusive. In this review, the structure and composition of SEIs are focused upon and the role of LiF in SEI is further analyzed. To this end, first, the development history of the SEI model is recounted. Second, the fundamental understanding of SEI is recalled. Third, the anode materials that can generate LiF in the SEI are categorized and discussed. Fourth, the characterization techniques of SEI layers are introduced. Fifth, the transport mechanism of Li+ ions within the SEI is discussed. Sixth, the physical properties of LiF are revisited. Seventh, the source of LiF is deeply analyzed. Finally, general conclusions and a perspective on the future research directions for SEI that may promote the large‐scale applications of lithium metal batteries is discussed.
An Exemplary Gay Scientist and Mentor: Martin Gouterman (1931–2020)
Authors: Ghosh Abhik 
Published: March 2021

AbstractMartin Gouterman (1931–2020) was one of the foundational figures of modern porphyrin science. After completing his Ph.D. at The University of Chicago in 1958, he joined Harvard, where he developed his eponymous four‐orbital model. In 1966, he moved to the University of Washington Seattle (UW). Here he came out as gay and helped set up Seattle's first gay rights group, the Dorian Society. At UW, Gouterman accomplished an “optical taxonomy” of the major classes of porphyrin derivatives and pioneered pressure‐sensitive paints based on phosphorescent platinum porphyrins to map the partial pressure of oxygen on airplane wings. Revered by his students and co‐workers for his brilliant yet gentle advising, Gouterman remains a beacon for a more humane and inclusive scientific enterprise.
High‐Energy Aqueous Sodium‐Ion Batteries
Authors: Jin Ting , Ji Xiao , Wang Peng‐Fei , Zhu Kunjie , Zhang Jiaxun , Cao Longsheng , Chen Long , Cui Chunyu , Deng Tao , Liu Sufu , Piao Nan , Liu Yongchang , Shen Chao , Xie Keyu , Jiao Lifang , Wang Chunsheng 
Published: March 2021

AbstractWater‐in‐salt electrolytes (WISE) have largely widened the electrochemical stability window (ESW) of aqueous electrolytes by formation of passivating solid electrolyte interphase (SEI) on anode and also absorption of the hydrophobic anion‐rich double layer on cathode. However, the cathodic limiting potential of WISE is still too high for most high‐capacity anodes in aqueous sodium‐ion batteries (ASIBs), and the cost of WISE is also too high for practical application. Herein, a low‐cost 19 m (m: mol kg−1) bi‐salts WISE with a wide ESW of 2.8 V was designed, where the low‐cost 17 m NaClO4 extends the anodic limiting potential to 4.4 V, while the fluorine‐containing salt (2 m NaOTF) extends the cathodic limiting potential to 1.6 V by forming the NaF–Na2O–NaOH SEI on anode. The 19 m NaClO4–NaOTF–H2O electrolyte enables a 1.75 V Na3V2(PO4)3∥Na3V2(PO4)3 full cell to deliver an appreciable energy density of 70 Wh kg−1 at 1 C with a capacity retention of 87.5 % after 100 cycles.
Polymer‐Coated Organic Crystals with Solvent‐Resistant Capacity and Optical Waveguiding Function
Authors: Lan Linfeng , Liu Huapeng , Yu Xu , Liu Xiaokong , Zhang Hongyu 
Published: March 2021

AbstractRecently, luminescent organic crystals have been widely studied as new optoelectronic materials. However, corrosion and dissolution of organic crystals by solvents have always been a great challenge for the application of organic crystals in various fields. In this work, we propose a general method of fabricating a solvent‐resistant coating to prevent organic crystals from being corroded or dissolved by organic solvents. The coatings involved layer‐by‐layer assembly of poly(diallyldimethylammonium) (PDDA) and poly(styrenesulfonate) (PSS) onto crystals, followed by immersing the coated crystals into polyvinyl alcohol (PVA) aqueous solutions for 2 minutes. The coated crystals can remain intact over 24 h in common organic solvents without being damaged and even insoluble in dichloromethane for 5 days. Moreover, the thin and transparent coatings have little effect on the optical properties of crystals which still have excellent optical waveguide performance with the coatings.
Tunable Hollow Nanoreactors for In Situ Synthesis of GeP Electrodes towards High‐Performance Sodium Ion Batteries
Authors: Zeng Tianbiao , He Hanna , Guan Huibin , Yuan Ruoxin , Liu Xingang , Zhang Chuhong 
Published: March 2021

AbstractThe practical application of germanium phosphide (GeP) in battery systems is seriously impeded referring to the sluggish reaction kinetics and severe volume change. Nanostructure design that elaborately resolves the above issues is highly desired but still remains a big challenge. Herein, unique hollow nanoreactors assembled with nitrogen‐doped carbon networks for in situ synthesis of the GeP electrodes are proposed for the first time. Such nanoreactors form a self‐supported conductive network, ensuring sufficient electrolyte infiltration and fast electron transport. They restrain crystal growth and accommodate the volume expansion of GeP simultaneously. Reaction kinetics and confinement effect are optimized through nanoreactor size regulation. The optimized GeP electrode has high reversible capacities and outstanding cyclability and rate performance for sodium storage, outperforming most previously reported phosphides.
Synthesis, spectral characterization, density functional theory studies, and biological screening of some transition metal complexes of a novel hydrazide–hydrazone ligand of isonicotinic acid
Authors: Tolan Dina A. , Kashar Tahani I. , Yoshizawa Kazunari , El‐Nahas Ahmed M. 
Published: March 2021

Novel Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) complexes (1–7) of hydrazide–hydrazone ligand (H2L) derived from the condensation of isonicotinic acid hydrazide with (Z)‐N′‐(2‐nitrobenzylidene)‐3‐oxobutanehydrazide have been prepared. The ligand and its chelates were characterized based on elemental analysis, spectral, thermal analysis, molar conductance, and magnetic moment measurements. Besides, density functional theory (DFT) computations have been conducted to study structures and energetics of the ligand and its complexes. The IR spectra showed that the ligand was chelated with the metal ion in a monobasic tridentate manner using ONO donors in all complexes except Zn(II) complex (5) where the ligand binds with Zn(II) ion as a dibasic tridentate utilizing ONO donors. The magnetic moment and electronic spectral data revealed octahedral and square pyramidal geometries for complexes (1, 7) and (2, 4, 5), respectively, whereas a square planar geometry was suggested for 3. DFT studies show that the Cd(II) center reveals interesting structural deviations from regular octahedral geometry in the resulting hexa‐coordinated complex [Cd(H2L)2].2H2O (6) assumes a trigonal prismatic (TP) structure for this complex. The antibacterial and antifungal activities of the ligand and its complexes have been investigated with different bacterial and fungal strains. The data revealed that Hg(II) complex (7) demonstrated a very good antibacterial and antifungal activity than others.Highlights

A new hydrazide–hydrazone ligand of isonicotinic acid was synthesized.
Seven mononuclear Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) complexes of the new ligand were prepared and characterized by different tools.
DFT studies have been carried out to study the structure of the ligand and its complexes.
Antimicrobial activities of the ligand and its complexes were studied against a variety of bacterial and fungal strains by using disk diffusion method and results were compared with standard drugs.
Removal of hard COD from acidic eucalyptus kraft pulp bleach plant effluent streams using oxidoreductases
Authors: Herold‐Majumdar Owik Matthias , Lopez Pita Sabela , Dominguez Estevez Fernando , Wawrzynczyk Joanna , Loureiro Pedro E. G. , Felby Claus 
Published: March 2021

AbstractThe bleach plant of a pulp and paper (P&P) mill presents a major source of wastewater containing toxic organic matter characterized as chemical oxygen demand (COD). Due to their high oxidizing power, oxidoreductases hold promise to be a key solution for the removal of dissolved organic material. Here, four oxidoreductases from different enzyme families were selected to treat bleach plant effluents. Haloperoxidase treatment of the final effluent resulted in the highest levels of decolorization (71%) and reduction of aromatic compounds (36%). Using single compound analysis, 27 low molecular weight compounds were found to be persistent throughout the wastewater treatment process and, therefore, classified as hard COD. The tested enzymes efficiently removed several of the identified COD compounds. Hence, this study suggests that the application of oxidoreductases will serve as an environmental‐friendly solution for reducing waste from P&P production.
CircSEC24A promotes IL‐1β‐induced apoptosis and inflammation in chondrocytes by regulating miR‐142‐5p/SOX5 axis
Authors: Shi Lin , Zhang Huiling , Sun Jianmin , Gao Xiang , Liu Chunhong 
Published: March 2021

AbstractBackgroundOsteoarthritis (OA) is a common joint disease. Currently, many studies have revealed that circular RNAs (circRNAs) are strongly related to the occurrence and development of diseases. Hence, we aimed to further elucidate the role and molecular mechanism of circRNA SEC24 homolog A, COPII coat complex component (circSEC24A) in OA.MethodsChondrocytes were treated with interleukin‐1β (IL‐1β) to establish OA cell model in vitro. The expression levels of circSEC24A, microRNA‐142‐5p (miR‐142‐5p), and sex‐determining region Y‐box protein 5 (SOX5) were determined by quantitative real‐time polymerase chain reaction. MTT and colony formation assays were used to determine cell proliferation. Cell apoptosis was detected by flow cytometry analysis. The protein levels of inflammatory factors and SOX5 were determined by western blot assay. The relationship between miR‐142‐5p and circSEC24A or SOX5 was confirmed using dual‐luciferase reporter assay and RNA immunoprecipitation assay.ResultsCircSEC24A and SOX5 expression were enhanced, while miR‐142‐5p level was reduced in OA cartilage tissues and chondrocytes. Overexpression of circSEC24A promoted IL‐1β‐induced injury through decreasing cell proliferation and increasing apoptosis and inflammation in chondrocytes. MiR‐142‐5p was a direct target of circSEC24A, and its upregulation ameliorated IL‐1β‐induced injury and abated the effect of oe‐circSEC24A in IL‐1β‐induced chondrocytes. Additionally, SOX5 was a downstream target of miR‐142‐5p, and its overexpression had a similar role with oe‐circSEC24A and reversed the impact of miR‐142‐5p in IL‐1β‐induced chondrocytes. CircSEC24A acted as a molecular sponge of miR‐142‐5p to regulate SOX5 expression in chondrocytes.ConclusionCircSEC24A aggravated IL‐1β‐induced injury via modulating miR‐142‐5p/SOX5 axis, providing possible targets for the clinical diagnosis and treatment of OA.
Preoperative and intraoperative factors predictive of complications and stricture recurrence following multiple urethroplasty techniques
Authors: Kay H. E. , Srikanth P. , Srivastava A. V. , Tijerina A. N. , Patel V. R. , Hauser N. , Laviana A. A. , Wolf J. S. , Osterberg E. C. 
Published: March 2021

AbstractObjectivesTo investigate factors predictive of postoperative recurrence and complications in patients undergoing urethroplasty for stricture repair at a single center.Patients and methodsWe retrospectively reviewed the records of 108 men who underwent urethroplasty for urethral stricture disease (USD) at a single center from 2016 to 2020. Demographic data, comorbidities, stricture history including etiology and prior treatments, patient‐reported symptoms, and outcomes data were collected for analysis. Data were analyzed in aggregate, then, stratified by type of urethroplasty performed. Descriptive statistics, univariate analysis, multivariate logistic regression, and intergroup comparisons were completed using STATA, with an alpha value of 0.05 and a confidence interval of 95%.ResultsThe median age of our patients was 58 years (interquartile range: 42‐69; range: 29‐83), with a median stricture length of 2.0 cm (interquartile range: 1.0‐4.5; range: 0.5‐10). The most common stricture etiology was iatrogenic (n = 33, 31%) and the most common urethroplasty was anterior anastomotic urethroplasty (n = 38, 35%), followed by buccal mucosal graft (BMG) urethroplasty (n = 35, 32%). Twenty‐four patients (22%) had stricture recurrence. Within the aggregate data, recurrence was significantly predicted by obesity (BMI > 30) (Odds Ratio [OR] 3.2, 95% Confidence Interval [CI]: 1.06‐10), and the presence of postoperative complications (OR 6.3, CI: 1.9‐21). The presence of any postoperative complications within 90 days was significantly predicted by stricture length ≥ 5 cm (OR 3.5, CI 1.09‐12) and recurrence (OR 6.0, CI 1.7‐21).ConclusionDespite serving as the most definitive treatment for urethral stricture management, stricture recurrence and postoperative complications are not uncommon after urethroplasty. Obesity and stricture length negatively impact outcomes while a penile stricture location is associated with a lower recurrence rate, though this is not statistically significant.