bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Re)Constructing the Baikal-Amur Mainline
Authors: Povoroznyuk Olga 
Published: October 2021

Abstract
The construction of the Baikal-Amur Mainline (BAM) in East Siberia and the Russian Far East in the 1970s and 1980s was the largest technological and social engineering project of late socialism. After the dissolution of the Soviet Union, the BAM was dogged by economic bust, decline, and public disillusionment. BAM-2, a recently launched state program of technological modernization, aims to complete a second railway track. The project elicits memories as well as new hopes and expectations, especially among “builders of the BAM.” This article explores continuity and change between BAM-1 and BAM-2. It argues that the reconstruction efforts of the postsocialist state are predetermined by the durability of the infrastructure as a materialization of collective identities, memories, and emotions.
Absence of the RNF213 p.R4810K variant may indicate a severe form of pediatric moyamoya disease in Japanese patients
Authors: Hara Shoko , Mukawa Maki , Akagawa Hiroyuki , Thamamongood Thiparpa , Inaji Motoki , Tanaka Yoji , Maehara Taketoshi , Kasuya Hidetoshi , Nariai Tadashi 
Published: October 2021

OBJECTIVE
The authors’ objective was to investigate the influence of the RNF213 p.R4810K variant on the clinical presentation and outcomes of Japanese pediatric patients with moyamoya disease.

METHODS
A total of 129 Japanese patients with pediatric-onset moyamoya disease (onset age ≤ 15 years) who visited the authors’ department from 2012 to 2020 participated in this study. After RNF213 p.R4810K genotyping of each patient was performed, the relationship between genotype and clinical presentation or outcomes, including onset age, initial presentation, surgical outcomes, and subsequent cerebrovascular events, was evaluated. Patients without the p.R4810K variant were tested for RNF213 variants other than p.R4810K. The authors especially focused on the results of patients who presented with moyamoya disease at younger than 1 year of age (infantile onset).

RESULTS
Compared with the patients with heterozygous variants, patients without the p.R4810K variant were younger at onset (7.1 ± 3.7 vs 4.4 ± 0.9 years), and all 4 patients with infantile onset lacked the p.R4810K variant. A greater proportion of patients without the p.R4810K variant presented with infarction than patients with the heterozygous variant (24.0% vs 7.6%) and a decreased proportion presented with transient ischemic attack (36.0% vs 71.7%). No significant correlation was observed between p.R4810K genotype and clinical outcomes, including surgical outcomes and subsequent cerebrovascular events; however, a decreased proportion of patients without the p.R4810K variant had good surgical outcomes compared with that of patients with the heterozygous variant (76.5% vs 92.2%). Among the 25 patients without the p.R4810K variant, 8 rare variants other than p.R4810K were identified. Three of 4 patients with infantile onset had RNF213 variants other than p.R4810K, which had a more severe functional effect on this gene than p.R4810K.

CONCLUSIONS
Absence of the RNF213 p.R4810K variant may be a novel biomarker for identification of a severe form of pediatric moyamoya disease.
A Rare Case of Juvenile Xanthogranuloma in 8 Months Old Baby with Dyslipidemia
Authors: Saiful Jessica Herlianez , Rina Gustia  
Published: October 2021

Background: Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis disease of childhood. But due to rarity of non Langerhans cell hystiosis itself, the exact prevalence of juvenile xanthogranuloma remain unknown with only a few epidemiological journal ever published. Juvenile xanthogranuloma usually wihout lipid abnormality and systemic involvement. But association between JXG and lipid abnormalities is still not well understood. We describe a patient with multiple cutaneous JXG who also developed hyperlipidemia.
Case: A case of a 8 months-old baby patient with juvenile xanthogranuloma is reported. Patient parents noticed yellowish dots on child’s face since six months ago, and it was gradually increase in size and number, and spread to trunks, upper and lower limb since 2 months ago. Patients got formula milk since 7 months ago. Patients father has uncontrolled hypercholesterolemia, and grandparents had controlled dyslipidemia. Dermatological state showed yellowish plaque and papule on the face, trunk, lower limb, and upper limb. Dermoscopy show yellowish papule with sun setting appearance and branched and linear vessel on orange yellow background. Laboratory finding showed elevated lipid serum. Foam cell and Touton giant cell is found on histopathology examination.
Discussion: The presented case demonstrates that skin lesions in patients with diagnosed JXG may have a variable clinical presentation, ranging from single to diffuse skin lesions, also present from the birth to childhood. The diagnosis requires histopathological confirmation to avoid misdiagnosis of malignant disease. Association between JXG and lipid abnormalities remain unknown, with most of the patient show normal lipid serum. Majority of patients presenting lesions limited to the skin requires only a strict dermatological observation.
Pendidikan Diniyah Formal (PDF) Meningkatkan Mutu Pendidikan Dayah Tradisional di Aceh
Authors: Zulkhairi Teuku 
Published: October 2021

AbstractThis study discusses the role of the Formal Diniyah Education program in improving the quality of traditional dayah education in Aceh. The study using a qualitative approach. The data were obtained through observation, documentation, and semi-structured interview with Diniyah Institution’s managers in Dayah Babussalam. The data collected were analyzed descriptively. The results showed that the presence of the Formal Diniyah Education program was a solution for Dayah Babussalam to improve the quality of her education. In practice, the presence of the Formal Diniyah Education program makes the existing traditional curriculum more developed. In addition, with the Imtiḥan Waṭoni (IW) examination, the quality of students also increases. Likewise, the presence of the Formal Diniyah Education program has also made modern education management integrated with Dayah Babussalam. The motivation of students to study in the dayah is also increasing where the Formal Diniyah Education diploma is very effective in "binding" the students to stay and endure in the dayah. Meanwhile, the challenge faced is the lack of expert teachers in teaching subjects in the Formal Diniyah Education curriculum.AbstrakPenelitian ini menggunakan pendekatan kualitatif, dengan tujuan membahas peran program Pendidikan Diniyah Formal (PDF) dalam meningkatkan mutu pendidikan dayah tradisional di Aceh. Data penelitian ini diperoleh melalui observasi, dokumentasi serta wawancara semi terstruktur dengan pengelola PDF di Dayah Babussalam. Data yang terkumpul dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa hadirnya program PDF menjadi solusi bagi Dayah Babussalam dalam upaya peningkatan mutu pendidikannya. Dalam pelaksanaannya, kehadiran program PDF membuat kurikulum tradisional yang sudah lebih dahulu ada menjadi lebih berkembang. Selain itu, dengan soal Imtiḥan Waṭani (IW) atau ujian nasional PDF yang berbahasa Arab membuat kualitas santri juga meningkat. Begitu juga, kehadiran program PDF juga membuat terintegrasinya manajemen pendidikan modern di Dayah Babussalam. Motivasi santri untuk belajar di dayah juga semakin meningkat dimana ijazah formal PDF ini sangat efektif “mengikat” para santri untuk bertahan di dayah. Sementara tantangan yang dihadapi yaitu kurangnya guru pakar dalam mengajarkan mata pelajaran dalam kurikulum PDF.
Pemberian Madu Pada Klien Diare Dengan Masalah Keperawatan Peningkatan Frekuensi BAB Di Desa Rajabasa Lama Lampung Timur
Authors: Putri Intan , Setiawati Setiawati 
Published: October 2021

ABSTRAK Diare di Indonesia merupakan penyakit endemis dan juga merupakan penyakit potensial Kejadian Luar Biasa (KLB) yang sering disertai dengan kematian. Angka kejadian diare Provinsi Lampung khususnya di Lampung Timur yaitu 21.588 kasus. Madu sebagai obat tradisional dengan berjuta khasiat sudah dikenal sejak zaman dahulu, bahkan Al-Quran menjelaskan manfaat lebah dan produknya sebagai penyembuh berbagai macam penyakit. Termasuk salah satunya diare. Madu adalah agen non alergi, nutrisi alami yang tinggi nilai antioksidan, anti-inflamasi, dan memiliki aktivitas antibakteri. Tujuan penelitian, untuk mendapatkan pengalaman dan kompetensi lebih dalam pemberian asuhan keperawatan komprehensif pemberian madu terhadap penurunan frekuensi bab. Adapun intervensi yang dilakukan dengan pemberian madu 1 sdm dengan dilarutkan kedalam air 100 cc selama 5 hari diminum secara rutin 3 kali sehari. Terdapat penurunan frekuensi bab setelah diberikan madu pada anak diare. Dengan demikian pemberian madu pada anak diare untuk menurunkan frekuensi buang air besar sangat efektif. Kata Kunci: Diare, Madu, Nutrisi ABSTRACTDiarrhea in Indonesia is an endemic disease and is also a potential disease of Extraordinary Events (KLB) which is often accompanied by death. The incidence of diarrhea in Lampung Province, especially in East Lampung is 21,588 cases. Honey as a traditional medicine with millions of benefits has been known since ancient times, even the Koran explains the benefits of bees and their products as a cure for various diseases. Including one of them diarrhea. Honey is a non-allergic agent, a natural nutrient that is high in antioxidant value, anti-inflammatory, and has antibacterial activity. The aim of the study was to gain more experience and competence in the provision of comprehensive nursing care for honey to reduce chapter frequency. The interventions were carried out by giving 1 tablespoon honey dissolved into 100 cc of water for 5 days drink routinely 3 times a day. There is a decrease in the frequency of chapters after giving honey to children with diarrhea. Thus giving honey to children with diarrhea to reduce the frequency of chapters is very effective. Keywords: diarrhea, honey, nutrient
Peningkatan Pengetahuan Wanita Usia Subur Tentang Efek Penggunaan Kontrasepsi Progestin Terhadap Kesehatan Organ Reproduksi
Authors: Veri Nora , Alchalidi Alchalidi , Dewita Dewita , Khaira Nuswatul - , Faisal T. Iskandar 
Published: October 2021

ABSTRAK Pemerintah menggalakan program Keluarga Berencana (KB) untuk mengendalikan pertumbuhan penduduk. Salah satu program KB adalah dengan penggunaan kontrasepsi. Metode kontrasepsi yang saat ini yang paling banyak digunakan oleh Wanita Usia Subur (WUS) adalah suntikan Depo Medroxy Progesterone Acetate (DMPA) yang berisi hormon progesteron. DMPA memiliki efek samping yang merugikan organ reproduksi untuk penggunaan jangka panjang. Tujuan kegiatan pengabdian dilakukan untuk meningkatkan pengetahuan wanita usia subur tentang efek samping penggunaan kontrasepsi hormonal DMPA jangka panjang pada organ reproduksi. Metode pelaksanaan adalah dengan edukasi peningkatan pengetahuan tentang kontrasepsi DMPA dengan sasaran wanita usia subur akseptor KB DMPA sebanyak 60 orang. Hasil kegiatan diperoleh bahwa mayoritas pengetahuan wanita usia subur pada kategori kurang pada saat pretest sebanyak 41 orang (68,33%) dan pada saat posttest mayoritas berada pada kategori baik sebanyak 53 orang (88,33%). Adanya peningkatan pengetahuan setelah dilakukan edukasi tentang penggunaan kontrasepsi DMPA dan efek samping yang ditimbulkan akibat penggunaan jangka panjang terhadap kesehatan organ reproduksi. Kata Kunci : Depo Medroxy Progesterone Acetate (DMPA), Wanita Usia Subur, Kontrasepsi, Keluarga Berencana ABSTRACT The government is promoting the Family Planning (KB) program to control population growth. One of the family planning programs is the use of contraception. The method of contraception currently most widely used by women of reproductive age is the injection of Depo Medroxy Progesterone Acetate (DMPA) which contains the progesterone hormone. DMPA has adverse side effects on reproductive organs for long-term use. The purpose of this service is to increase the knowledge of women of reproductive age about the side effects of long-term use of DMPA hormonal contraceptives on the reproductive organs. The method of implementation is education to increase knowledge about DMPA contraception with the target of women of reproductive age DMPA to acceptors as many as 60 people. The results of the activity showed that the majority of knowledge of women of reproductive age were in the lack knowledge at the time of the pretest as many as 41 people (68.33%) and at the time of the posttest the majority were in the good knowledge category as many as 53 people (88.33%). There is an increase in knowledge after education about the use of DMPA contraceptives and the side effects caused by long-term use on the health of the reproductive organs. Keywords: Depo Medroxy Progesterone Acetate (DMPA), women of reproductive age, Contraception, Family Planning
Pembuatan Dan Pengaplikasian Sabun Cuci Tangan Lidah Buaya Dalam Rangka Pemberdayaan Masyarakat Desa Kunir Di Era Pandemic Covid19
Authors: Eka Amalia 
Published: October 2021

ABSTRAK Saat ini masyarakat sedang menghadapi wabah Virus Corona (Covid-19) yang sangat spesifik namun mempunyai efek kompleksitas yang tinggi, bahkan luar biasa, karena ekspektasinya tidak hanya di dunia kesehatan saja namun merambah semua sendi kehidupan manusia. Desa Kunir termasuk desa yang juga mengalami wabah Covid-19, Hal yang dapat masyarakat lakukan untuk memutus rantai penyebaran virus Covid-19 adalah dengan rajin mencuci tangan dengan sabun dan air bersih, serta menggunakan hand sanitizer secara berkala. Lidah buaya memiliki kandungan saponin yang mempunyai kemampuan untuk membersihkan dan bersifat antiseptik. Tujuan setelah pemberdayaan masyarakat desa kunir, diharapkan dapat meningkatkan pengetahuan dan kemampuan dalam memanfaatkan lidah buaya yang ada disekitar tempat tinggal untuk digunakan sebagai sabun cuci tangan. Adapun kegiatan yang dilakukan berupa sosialisasi dan pemberdayaan masyarakat desa kunir dalam pembuatan dan pengaplikasian sabun cuci tangan dari lidah buaya. Terdapat peningkatan pengetahuan dan kemampuan tentang lidah buaya sebagai sabun cuci tangan yaitu 70 % diperoleh dari kuisioner sebelum dan sesudah dilaksanakan pembelajaran Kata Kunci : sabun cuci tangan, lidah buaya, desa kunir ABSTRACTCurrently, the community is facing a very specific Corona Virus (Covid-19) outbreak but has a high, even extraordinary complexity effect because the expectations are not only in the world of health but also penetrate all aspects of human life. Kunir Village is one of the villages that have also experienced the Covid-19 outbreak. What people can do to break the chain of spreading the Covid-19 virus is to diligently wash their hands with soap and clean water, and use hand sanitizers regularly. Aloe vera contains saponins which have the ability to clean and are antiseptic. The goal after empowering the people of turmeric village is expected to increase their knowledge and ability to use aloe vera around the residence to be used as hand washing soap. The activities carried out are in the form of socialization and empowerment of the village community in turmeric in the manufacture and application of handwashing soap from aloe vera. There is an increase in knowledge and abilities about aloe vera as hand washing soap, which is 70% obtained from questionnaires before and after the learning is carried out. Keywords: hand washing soap, aloe vera, kunir village
The effect of inquiry learning model on mathematical problem solving abilities in terms of grade X high school students learning style
Authors: Risno Risno , Sulasteri Sri , Suharti Suharti , Nur Fitriani , Rasyid Muhammad Rusydi 
Published: October 2021

Tujuan penelitian eksperimen dengan desain faktorial ini untuk mengetahui gambaran kemampuan menyelesaikan masalah matematika siswa jika menerapkan model pembelajaran inkuiri dan model pembelajaran langsung, serta mengetahui interaksi gaya belajar dengan model pembelajaran inkuiri pada kemampuan menyelesaikan masalah matematika siswa kelas X SMAN 4 Luwu Utara. Pengambilan sampel memakai teknik sampling purposive dan diperoleh sampel sebanyak 68 siswa dari populasi 238 siswa kelas X SMAN 4 Luwu Utara. Instrumen penelitian berupa angket gaya belajar serta soal tes kemampuan menyelesaikan masalah matematika. Analisis data menggunakan statistik deskriptif dan juga statistik inferensial berupa uji Anova 2 Arah. Hasil perhitungan mengungkapkan bahwa tidak ada perbedaan kemampuan menyelesaikan masalah matematika yang belajar menggunakan model pembelajaran inkuiri dan model pembelajaran langsung, tidak ada perbedaan kemampuan menyelesaikan masalah matematika yang signifikan antara siswa dengan pembelajaran model inkuiri dan model langsung ditinjau dari gaya belajar mereka, namun ada interaksi antara model pembelajaran inkuiri pada kemampuan menyelesaikan masalah matematika jika ditinjau dari gaya belajar siswa.
Constructing the ceRNA Regulatory Network and Combining Immune Cells to Evaluate Prognosis of Colon Cancer Patients
Authors: Xu Jiasheng , Ling Tianyi , Dai Siqi , Han Shuwen , Ding Kefeng 
Published: October 2021

Objective: This study was conducted in order to construct a competitive endogenous RNA (ceRNA) network to screen RNA that plays an important role in colon cancer and to construct a model to predict the prognosis of patients.Methods: The gene expression data of colon cancer were downloaded from the TCGA database. The difference was analyzed by the R software and the ceRNA network was constructed. The survival-related RNA was screened out by combining with clinical information, and the prognosis model was established by lasso regression. CIBERSORT was used to analyze the infiltration of immune cells in colon cancer, and the differential expression of immune cells related to survival was screened out by combining clinical information. The correlation between RNA and immune cells was analyzed by lasso regression. PCR was used to verify the expression of seven RNAs in colon cancer patients with different prognoses.Results: Two hundred and fifteen lncRNAs, 357 miRNAs, and 2,955 mRNAs were differentially expressed in colon cancer. The constructed ceRNA network contains 18 lncRNAs, 42 miRNAs, and 168 mRNAs, of which 18 RNAs are significantly related to survival. Through lasso analysis, we selected seven optimal RNA construction models. The AUC value of the model was greater than 0.7, and there was a significant difference in the survival rate between the high- and low-risk groups. Two kinds of immune cells related to the prognosis of patients were screened out. The results showed that the expression of seven RNA markers in colon cancer patients with different prognoses was basically consistent with the model analysis.Conclusion: We have established the regulatory network of ceRNA in colon cancer, screened out seven core RNAs and two kinds of immune cells, and constructed a comprehensive prognosis model of colon cancer patients.
Matrix Stiffness Affects Glycocalyx Expression in Cultured Endothelial Cells
Authors: Mahmoud Marwa , Cancel Limary , Tarbell John M. 
Published: October 2021

Rationale: The endothelial cell glycocalyx (GCX) is a mechanosensor that plays a key role in protecting against vascular diseases. We have previously shown that age/disease mediated matrix stiffness inhibits the glycocalyx glycosaminoglycan heparan sulfate and its core protein Glypican 1 in human umbilical vein endothelial cells, rat fat pad endothelial cells and in a mouse model of age-mediated stiffness. Glypican 1 inhibition resulted in enhanced endothelial cell dysfunction. Endothelial cell culture typically occurs on stiff matrices such as plastic or glass. For the study of the endothelial GCX specifically it is important to culture cells on soft matrices to preserve GCX expression. To test the generality of this statement, we hypothesized that stiff matrices inhibit GCX expression and consequently endothelial cell function in additional cell types: bovine aortic endothelial cells, mouse aortic endothelial cell and mouse brain endothelial cells.Methods and Results: All cell types cultured on glass showed reduced GCX heparan sulfate expression compared to cells cultured on either soft polyacrylamide (PA) gels of a substrate stiffness of 2.5 kPa (mimicking the stiffness of young, healthy arteries) or on either stiff gels 10 kPa (mimicking the stiffness of old, diseased arteries). Specific cell types showed reduced expression of GCX protein Glypican 1 (4 of 5 cell types) and hyaluronic acid (2 of 5 cell types) on glass vs soft gels.Conclusion: Matrix stiffness affects GCX expression in endothelial cells. Therefore, the study of the endothelial glycocalyx on stiff matrices (glass/plastic) is not recommended for specific cell types.
Immunomodulatory Effects of Perioperative Dexmedetomidine in Ovarian Cancer: An In Vitro and Xenograft Mouse Model Study
Authors: Shin Seokyung , Kim Ki Jun , Hwang Hye Jeong , Noh Sewon , Oh Ju Eun , Yoo Young-Chul 
Published: October 2021

BackgroundThe surgical stress response (SSR) causes immunosuppression which may cause residual tumor growth and micrometastasis after cancer surgery. We investigated whether dexmedetomidine affects cancer cell behavior and immune function in an ovarian cancer xenograft mouse model.MethodsThe effect of dexmedetomidine on cell viability and cell cycle was assessed using SK-OV-3 cells at drug concentrations of 0.5, 0.1, 5, and 10 µg mL-1. BALB/c nude mice were used for the ovarian cancer model with the Dexmedetomidine group (n=6) undergoing surgery with dexmedetomidine infusion and the Control group (n=6) with saline infusion for 4 weeks. Natural killer (NK) cell activity, serum proinflammatory cytokines, and cortisol were measured at predetermined time points and tumor burden was assessed 4 weeks after surgery.ResultsDexmedetomidine had no effect on cell viability or cell cycle. Following a sharp decrease on postoperative day (POD) 1, NK cell activity recovered faster in the Dexmedetomidine group with significant difference vs. the Control group on POD 3 (P=0.028). In the Dexmedetomidine group, cortisol levels were lower on POD 3 (P=0.004) and TNF-α levels were lower at 4 weeks after surgery (P&lt;0.001) compared to the Control group. The Dexmedetomidine group showed lower tumor burden at 4 weeks vs. the Control group as observed by both tumor weight (P&lt;0.001) and thein vivoimaging system (P=0.03).ConclusionsDexmedetomidine infusion may improve ovarian cancer surgery outcome by suppressing the SSR and stress mediator release. Further studies are needed to elucidate the mechanisms by which dexmedetomidine acts on cancer and immune cells.