bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGUATAN NILAI NASIONALISME MELALUI PEMANFAATAN MEDIA SOSIAL DALAM PENDIDIKAN PANCASILA PERSPEKTIF KEWARGANEGARAAN DIGITAL
Authors: Nugroho Dedy Ari , Khairurrasyd Khairurrasyd 
Published: December 2024

Penelitian ini membahas pesatnya teknologi informasi membawa pengaruh pada remaja yang kebanyakan mengakses media sosial. Perkembangan teknologi ini kebanyakan membuat remaja tidak bisa memilah informasi yang tersebar positif dan negatifnya. Penguatan nilai nasionalisme dengan pemanfaatan media sosial dimanfaatkan dalam membangun kualitas pendidikan di Indonesia yang cinta akan tanah airnya sesuai dengan kewarganegaraan digital. Penelitian ini bertujuan untuk mengkaji dan mendeskripsikan penguatan nilai nasionalisme melalui pemanfaatan media sosial dalam Pendidikan Pancasila. Metode penelitian yang digunakan adalah metode kualitatif dengan menggunakan teknik observasi, wawancara, dan dokumentasi. Teknik analisis data yang ditemukan adalah reduksi data, penyajian, dan penarikan kesimpulan. Hasil penelitian ini mengungkapkan hal-hal berikut: 1) Strategi pemanfaatan media sosial oleh guru dalam Pendidikan Pancasila menunjang pemahaman peserta didik mulai dari perencanaan, mental dan pondasi materi baik dari internet ataupun buku pegangan guru, memanfaatkan media instagram untuk peserta didik dapat mempelajari materi lewat media sosial tentang nasionalisme. 2) Dalam pemanfaatannya tersebut terlihat penguatan nilai nasionalisme yang diajarkan oleh guru melalui pemanfaatan media sosial instagram yang menjadi tolak ukur dan acuan peserta didik untuk mengupload tugas yang diberikan untuk menunjang pemahaman peserta didik terhadap nasionalismenya.
Efektivitas Model Pembelajaran Project Based Learning Terhadap Hasil Belajar Kognitif Siswa pada Mata Pelajaran PPKn di SMP Negeri 21 Banjarmasin
Authors: Adawiah Rabiatul , Maulida Dina 
Published: December 2024

Penelitian ini bertujuan untuk mengetahui efektivitas model belajar berbasis proyek dalam meningkatkan hasil belajar kognitif siswa. Penelitian ini menggunakan pendekatan kuantitatif. Penelitian dilakukan di SMP Negeri 21 Banjarmasin dengan mengambil kelas VIII A sebagai kelas ekseperimen dan kelas VIII D sebagai kelas kontrol. Data dikumpulkan dengan menggunakan tes. Data dianalisis dengan uji T- Dependent menggunakan bantuan aplikasi SPSS 25. Setelah dilakukan analisa dengan uji T-Dependent diperoleh peningkatan nilai di kelas eksperimen saat pree test dengan nilai rata-rata 59,35 menjadi 85,16 saat post test dengan nilai P sebesar 0,000. Sebaliknya, hasil analisis T-dependency pada kelas kontrol mencapai 60,34 pada tes sebelumnya (pree test) dan terjadi peningkatan pada tes terakhir (post awal) menjadi 77,93 dengan nilai P yaitu 0,000. Perbandingan antara skor menggunakan PjBL dan model konvensional yang diuji menggunakan uji independent T-Test terakhir diperoleh nilai t sebesar 2,360 dan nilai P 0,02, artinya penerapan model belajar konvensional dengan model belajar PjBL akan menghasilkan kemampuan kognitif siswa yang berbeda. Dengan kata lain penerapan pembelajaran berbasis proyek efektif dalam meningkatkan hasil belajar kognitif siswa
Vertebral Body Tethering Surgery
Authors: Phan Tiffany N. , Wren Tishya A.L. , Heffernan Michael J. , Tetreault Tyler A. , Parent Stefan , Welborn Michelle C. , Skaggs David L. , Illingworth Kenneth D. , Andras Lindsay M. ,   the Pediatric Spine Study Group
Published: December 2024

Background:
Much enthusiasm has been generated around vertebral body tethering (VBT) as an alternative to fusion treatment. However, the majority of studies have shown little difference between coronal curve magnitude on the first postoperative erect radiograph and that at final follow-up, suggesting that VBT is not consistently modulating spine growth in a manner that substantially affects coronal curve magnitude.

Methods:
All patients with adolescent idiopathic scoliosis (AIS) who underwent VBT between December 2013 and June 2020 and subsequently had at least 2 years of follow-up in a multicenter registry were reviewed. The change in coronal curve magnitude was calculated by subtracting the magnitude at the time of final follow-up from that on the first postoperative erect radiograph. A change of <5° was considered to be within normal measurement variability.

Results:
One hundred and ten patients met the inclusion criteria (racial breakdown: 94 White, 6 Black/African American, 3 Asian, 2 Middle Eastern, 1 mixed race, and 4 uncertain/unspecified; ethnicity: 87 not Hispanic or Latino, 1 Hispanic/Latino, and 22 did not report their ethnicity). Their mean age was 12.9 years (standard deviation [SD], 1.3 years) and the mean follow-up was 3.7 years (range, 2.0 to 6.9 years). A mean of 6.6 levels were tethered. The preoperative mean coronal curve magnitude was 51.0° (range, 32° to 75°), which corrected to a mean of 27.3° (range, 10° to 53°) on the first postoperative erect radiograph. At the time of final follow-up, the mean coronal curve magnitude was 30.9° (range, −50° to 69°), and 49.1% (54) of the 110 curves were stable (the coronal curve magnitude at final follow-up was within 5° of that on the first postoperative erect radiograph). A total of 42.7% (47) had >5° of increase in coronal curve magnitude following the initial postoperative erect radiograph, whereas 8.2% (9) showed a >5° increase during the follow-up period. Five of the 9 patients (4.5% of the series) had a >10° decrease, with 2 of the 5 having overcorrection, ending up with 31° and 50° curves in the opposite direction.

Conclusions:
Although VBT holds promise and many (49.1%) of the 110 curves in this series remained stable from the first postoperative erect to the final follow-up radiograph, only 9 demonstrated a decrease in coronal curve magnitude over time, including 2 that overcorrected. Further research is needed to identify the factors differentiating among patients who had curve progression, did not have progression, or had overcorrection to determine which patients are more likely to benefit from VBT.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Eficiência dos Municípios da Região do Cariri Cearense na Pandemia de COVID-19: uma Crítica Usando a Análise de Envoltória de Dados (DEA)
Authors: VALÉRIO DE OLIVEIRA ANTONIO RAFAEL , RODRIGUES CHAGAS MILTON JARBAS , DA CRUZ FEITOSA MARIA ISABEL , CAVALCANTE MOTA SAMUEL 
Published: December 2024

Objetivo da pesquisa: Analisar o desempenho dos municípios da região do Cariri Cearense na pandemia do Coronavírus.
Enquadramento teórico: O Brasil tem sido severamente impactado pela pandemia de COVID-19, os graves problemas socioeconômicos que o país enfrenta desde antes da detecção do primeiro caso da doença e a distribuição populacional, com padrões e realidades locais bastante heterogêneas, ocasionaram comportamento distintos de proteção, notadamente no âmbito dos governos locais.
Metodologia: Para o cálculo da eficiência dos 26 municípios, utilizou-se a Análise Envoltória de Dados (DEA), por meio do Modelo BCC (Banker-Charnes-Cooper), com orientação para outputs.
Resultados: Os resultados indicam que 8 municípios analisados atingiram o índice de eficiência de 100%. Além disso, o melhor nível de eficiência não necessariamente ocorre naqueles que tiveram maiores gastos per capita com saúde. O número de notificados foi a variável que apresentou o maior potencial de melhoria, requerendo mais atenção dos gestores.
Originalidade: A avaliação da eficiência no contexto da pandemia da covid-19 em municípios de uma região que possuía a maior taxa de índice e contágio, além de utilizar o Índice de Efetividade da Gestão Municipal –Dimensão Saúde (IEGM_Saúde), do Tribunal de Contas do Estado do Ceará, como output, esse último, ainda não explorado nos estudos analisados.
Contribuições teóricas e práticas: O modelo apresentado com a proposta inversa para determinadas variáveis, pode ser utilizado por pesquisadores e órgãos públicos as secretarias municipais para a formulação de políticas públicas e tomadas de decisões.
Palavras-chave: COVID-19. Eficiência. Análise Envoltória de Dados (DEA).
Molecular insights into a distinct class of terpenoid cyclases
Authors: Guo Rey-Ting , Li Siyu , Huang Jian-Wen , Min Jian , Li Hao , Ning Meidan , Zhou Shuyu , Yang Yu , Chen Chun-Chi 
Published: December 2024

Abstract

Terpenoid cyclases (TCs) account for the synthesis of the most widespread and diverse natural compounds. A sesquiterpene cyclase termed BcABA3 from an abscisic acid-producing fungus Botrytis cinerea that yields (2Z,4E)-a-ionylideneethane but lacks signature feature of canonical TCs represents a distinct type of TCs. Here, we report the crystal structures of BcABA3, a closely related RuABA3 from Rutstroemia sp. and a bacterial SkABA3 from Shimazuella kribbensis. These ABA3 proteins adopt an all-a-helix fold and bind pyrophosphate moiety of farnesyl pyrophosphate by Glu-chelated Mg2+ ion cluster. We conduct mutagenesis experiments to validate the role of the substrate-binding residues. SkABA3 appears to yield compounds that are distinct from (2Z,4E)-a-ionylideneethane. These results not only provide the molecular insight into ABA3 proteins that serve as an important basis to the future investigation of this class of TCs, but also reveal the existence of more uncharacterized terpenoids synthesized via dedicated machineries.
Hydrothermal Pretreatment of Food Waste Enhances Performance of Anaerobic Co-digestion With Sludge
Authors: Johnravindar Davidraj , Zhao Jun , Manu Mathikere Krishnegowda , Wong Jonathan Woon Chung 
Published: December 2024

Abstract

Food waste (FW) presents a significant opportunity for renewable energy production through anaerobic digestion (AD) when subjected to appropriate treatment. This study investigates the impact of thermal hydrolysis pretreatment (THP) on FW at varying temperature levels (90°C, 120°C, and 140°C) prior to mesophilic anaerobic co-digestion with sewage sludge (SS). Results demonstrate enhanced FW hydrolysis at 120°C, leading to a cumulative methane yield of 324.39 ± 4.5 mL/gVSadd, representing a 41.75% increase over untreated FW (228.83 ± 1.13 mL/gVSadd). Shifts in microbial communities, particularly Methanosarcina, Methanobactrium, and Methanobrevibacter, support efficient methanogenesis. Co-digestion of FW pretreated at 120°C yields maximum energy production of 11.48 MJ/t, a 49.47% improvement compared to untreated processes. The economic analysis underscores the profitability of co-digestion with FW pretreated at 120°C. These findings highlight the potential for enhanced methane production and energy conversion efficiency with hydrothermally pretreated FW and SS co-digestion.
Teaching opportunities for anamnesis interviews through AI based teaching role plays: a survey with online learning students from health study programs
Authors: Rädel-Ablass Katharina , Schliz Klaus , Schlick Cornelia , Meindl Benjamin , Pahr-Hosbach Sandra , Schwendemann Hanna , Rupp Stephanie , Roddewig Marion , Miersch Claudia 
Published: December 2024

Abstract

Background This study presents a novel approach to educational role-playing through an AI-based bot, leveraging GPT-4 to simulate anamnesis interviews in various learning scenarios. Developed collaboratively by an interdisciplinary team of university lecturers, the bot provides a platform for students of different health study programs to engage in complex patient-health professional conversations, offering an alternative to traditional role plays with actors or real patients.
Methods This study utilized a GPT-4 based digital teaching assistant to train anamnesis interviews in virtual settings with students from different online health care study programs. Student’s satisfaction, virtual patient’s accuracy, its realism, and quality was evaluated with a quantitative survey.
Results The evaluation of the bot focused on student feedback, highlighting a preference for the AI-driven method due to its immersive and interactive nature. Preliminary results show that students consistently rate the language ability of the AI model positively. More than 80% of students rated the professional and content-related precision of the virtual patient as good to excellent. Even as a text-based chatbot, the vast majority of students see a fairly close to very close relationship to a real anamnesis interview. The results further indicate that students even prefer this training approach to traditional in-person role-plays.
Conclusions The study underscores the bot's potential as a versatile tool for enriching learning experiences across multiple health disciplines, signaling a meaningful shift in educational practices towards the integration of AI technologies.
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells
Authors: Whitehead Michael , Harvey Joshua P. , Sladen Paul E. , Becchi Giada , Singh Kritarth , Sun Yujiao Jennifer , Burgoyne Thomas , Duchen Michael R. , Yu-Wai-Man Patrick , Cheetham Michael E. 
Published: December 2024

Abstract

Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, characterised by the selective loss of retinal ganglion cells (RGCs). Over 60% of DOA cases are caused by pathogenic variants in the OPA1 gene, which encodes a dynamin-related GTPase protein. OPA1 plays a key role in the maintenance of the mitochondrial network, mitochondrial DNA integrity and bioenergetic function. However, our current understanding of how OPA1 dysfunction contributes to vision loss in DOA patients has been limited by access to disease-relevant, patient-derived RGCs. Here, we used induced pluripotent stem cell (iPSC)-RGCs to study how OPA1 affects cellular homeostasis in human RGCs, the most vulnerable cell type in DOA. iPSCs derived from OPA1 DOA patients and isogenic CRISPR-Cas9-corrected iPSCs were differentiated to iPSC-RGCs. Defects in mitochondrial networks and increased levels of reactive oxygen species were observed in iPSC-RGCs carrying OPA1 pathogenic variants. Ultrastructural analyses also revealed changes in mitochondrial shape and cristae structure, with decreased endoplasmic reticulum (ER):mitochondrial contact length in DOA iPSC-RGCs. Mitochondrial membrane potential was reduced and its maintenance was also impaired following inhibition of the F1Fo-ATP synthase with oligomycin, suggesting that mitochondrial membrane potential is maintained in DOA iPSC-RGCs through reversal of the ATP synthase and ATP hydrolysis. These impairments in mitochondrial structure and function were associated with defects in cytosolic calcium buffering following ER calcium release and store-operated calcium entry, and following stimulation with the excitatory neurotransmitter glutamate. In response to mitochondrial calcium overload, DOA iPSC-RGCs exhibited increased sensitivity to opening of the mitochondrial permeability transition pore. These data reveal novel aspects of DOA pathogenesis in patient-derived RGCs. The findings suggest a mechanism in which primary defects in mitochondrial network dynamics disrupt core mitochondrial functions, including bioenergetics, calcium homeostasis, and opening of the permeability transition pore, which may contribute to vision loss in DOA patients.
Nanocellulose Chiral Synergistic Effect Enhances Circularly Polarized Luminescence of Lanthanide Electric Dipole Transition Bands
Authors: Chang Hui , Kang Wenjia , Zhao Xinyu , Chang Shuai , Li Xinping , Luo Yuxia , Xiong Chuanyin , Zhu Xunjin , Zhang Zhao 
Published: December 2024

Abstract

The circularly polarized luminescence (CPL) of Eu(III) ion has been highly valued due to their high asymmetry factor and characteristic luminescence. However, the most reported CPL of Eu3+ ion is contributed from the magnetic dipole transitions but very less from the electric dipole transitions due to the influence of coordination fields. Until now, the amplification of the asymmetry factor (glum) of CPL is mainly due to magnetic dipole transition glum (glum−mag), while electric dipole transition glum (glum−ele) has almost no amplification. In this study, nanocellulose chiral films were synergistically induced with chiral β-diketones Eu-TFC (D/L) and hybrid photonic crystal films CNC@Eu-TFC (D/L) targeted methods for achieving electric dipole transition CPL and glum−ele of Eu3+ ions. The glum−ele was higher than glum−mag, achieving a reversal of glum−ele and glum−mag sizes. The glum of CNC@Eu-TFC (L) was relatively higher than that of CNC@Eu-TFC (D), the main reason for which was that the macroscopic chirality of the nanocellulose film, with a left-handed spiral structure, had a stronger synergistic induction effect with left-handed Eu-TFC (L). Therefore, utilizing the macroscopic chirality of CNC films could effectively amplify the difficulty to activate glum−ele of Eu3+ ions, providing a new approach for its preparation in high-performance CPL materials.
Tinospora Cordifolia Bioactive Compounds as a Novel Sterol 14a- Demethylase (Cyp51) Inhibitor: an Insilico Study
Authors: Mesileya Kolawole T. , onyeka precious , Adaramola Iyidola M. , Igbalaye Quareebat O. , Bodun Damilola S. , Alao Wisdom K. , Jibril Salim Y. , Mohammed Mustapha S. , Bowaje Adedayo S. , Adeleye Adebisi M. , omotuyi olaposi 
Published: December 2024

Abstract

Background:
For both endemic and non-endemic areas, Trypanosoma cruzi is the cause of Chagas disease, which can be life-threatening. Oversight: The entire life cycle of T. cruzi relies on the natural production of sterol through the 14-α-demethylase metabolic pathway. Many of the medications now used to treat Chagas disease have undesirable side effects and are resistant to treatment. Using bioactive chemicals from Tinospora cordifolia, this study attempted to anticipate the inhibitor(s) of sterol 14a-demethylase (cyp51). Utilizing the glide model, a library including one hundred twenty-two (122) compounds from Tinospora cordifoliawas screened against sterol 14-α-demethylase (cyp51). The e-pharmacophore, pharmacokinetics profile and generalized born surface area (mm-gbsa) in molecular mechanics were performed utilizing four (4) leads and the maestro-schrodinger suite (2022).
Results:
The results indicate that the top four compounds outperform the standard drug (benznidazole). In binding affinity to 14-α-demethylase, as evidenced by docking scores ranging from -11.397 kcal/mol to -9.539 kcal/mol. Furthermore, the top compounds did not appear to be cytotoxic by ADMET projections. The hit compounds' density functional theory results showed that their Ehomo values ranged from -5.59 eV to -5.80 eV, indicating that the hit molecules are electron donors.
Conclusions:
This study identifies potential Tinospora cordifolia inhibitors with higher binding affinities and provides a detailed description of their interaction with the target protein. Although the results are favorable, further in vivo and in vitro studies are required to confirm these compounds' potential as anti-Chagas agents.
Brain structure in Triple X syndrome: Regional gray matter volume and cortical thickness in adult women with 47,XXX karyotype
Authors: Domes Gregor , Croyé Marie-Anne , Freilinger Petra , Bohlscheid Andreas , Willinek Winfried A. , Meyer Jobst 
Published: December 2024

Abstract

Background
Changes in the brain structure of women with Triple X syndrome (karyotype 47,XXX) have been described in a few studies to date, including reduced total brain volume and regional reductions in gray substance in cortical and subcortical areas.
Methods
Using voxel-based morphometry (VBM) and surface-based morphometry (SBM), we investigated regional gray matter changes in a sample of n = 20 adult women with 47,XXX karyotype using T1-weighted 3T MRI scans.
Results
Compared to an age- and education-matched control group, the VBM revealed decreased regional gray matter volumes in the hippocampus, amygdala, parts of the basal ganglia, insula, prefrontal areas and cerebellum. To a lesser extent, we also noted specific reductions in cortical thickness in a smaller part of those regions.
Conclusion
This network is significantly involved in the processing of cognitive, affective, and social stimuli and is a potential neuronal correlate of the autism-like social-cognitive problems described in 47,XXX in the literature.
Gender and Group Preference Differentiation: Impacts on Problem Finding and Solving
Authors: Abuhadeeda Motlaq , Alaifan Amthal , Hamza Eid Abo 
Published: December 2024

Abstract

Purpose: This study examines the impact of gender on the ability to solve creative problems among intellectually gifted secondary students in Kuwait.
Methodology: The study includes a sample of 98 individuals. The study used the Realistic Problem Generation and Realistic Presented Problems evaluations, in conjunction with the Collectivism/Individualism Creativity Preference Scale, to measure students' problem-solving and creative aptitudes. Statistical analysis was conducted using cluster analysis and the Point-Biserial correlation coefficient.
Findings: The findings suggest that the correlation between individual creativity and problem-solving skills is stronger than the correlation between group creativity and problem-solving skills. This challenges the idea that gender has a substantial influence on creative problem-solving abilities.
Originality: The results highlight the importance of personalized educational strategies that provide to the unique talents of gifted students, advocating for equal opportunities regardless of gender to enhance academic achievement.
Probing the Effect of Pre- and Post-heating in Resistance Spot Welded Multi-material TWB system through Response Surface Methodology
Authors: Mandal Anand Kumar , Kumar Rakesh , Kumar Bikash , Rani Deepika 
Published: December 2024

Abstract

This study investigates the optimization of the resistance spot welding (RSW) process in a three-sheet, multi-material configuration, utilizing steel alloys of varying thicknesses, namely, AISI 1035 (1.2 mm), ASTM A36 (2.0 mm), and IFHS 350 (2.5 mm). Advanced pulse modulation schemes, including single pulse (welding cycle), double pulse (preheating + welding and welding + post-heating cycle), and triple pulse (preheating + welding + post-heating cycle), were systematically analyzed. Response Surface Methodology (RSM) was employed to predict key weld outcomes, i.e., weld nugget diameter, elongation, and failure load; validated via Analysis of Variance (ANOVA). Microstructural analysis through Electron Backscatter Diffraction (EBSD) focused on kernel average misorientation (KAM) and grey-scale image quality (IQ) mapping to assess lattice distortion, dislocation density, and internal stresses. Results indicated that double pulse (welding + post-heating) and triple pulse cycle induce high dislocation density (~ 250–300 × 10¹² m⁻²) and non-diffusional martensitic transformation, leading to significant brittleness, reduced elongation, and failure load. In contrast, optimized preheating in the double pulse cycle (preheating + welding) increased weld nugget diameter from ~.5 → 10 mm, joint failure load from ~15 → 19.5 kN, and elongation from ~9 to 12.5 mm. This work provides critical insights into RSW process behaviour for multi-material, multi-thickness configurations, advancing the understanding of high-performance applications in complex welded structures.