bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of COVID-19 lockdown on university students’ anxiety disorder in Italy
Authors: Busetta Giovanni , Campolo Maria Gabriella , Fiorillo Fabio , Pagani Laura , Panarello Demetrio , Augello Valeria 
Published: October 2021

AbstractThe COVID-19 pandemic has highlighted the vulnerability of specific population sections, with regards to economic and work conditions, mental and physical well-being, and context-based factors, emphasizing the need for timely policy measures aimed at counteracting the Italian economic framework’s fragility—which poorly adapts to unexpected circumstances. Identifying the most vulnerable groups is, therefore, essential with a view to carrying out targeted measures. Concerning University, the economic downturn caused by COVID-19 could likely result in a decrease in enrollments to both the first and further years of study, with significant consequences on the future of students and the system as a whole. The class of students is of great interest, as it is made up of individuals differing from each other in many ways. Our investigation is aimed at observing anxiety levels filtering the perception of one’s anxiety state in a highly stressful time such as the pandemic from the usual anxiety levels. This evaluation allows us to evaluate the similarity of individual behaviors during the lockdown period with those from the previous period.
Inflammatory arthritis complicating galactosialidosis: a case report
Authors: Verkuil F. , Bosch A. M. , Struijs P. A. A. , Hemke R. , van den Berg J. M. 
Published: October 2021

Abstract
Background
Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism. We report, for the first time, the case of a child affected by GS presenting with recurrent episodes of extensive joint inflammation in both knee joints. The aim of this case-report is to describe the clinical presentation as well as the laboratory, radiologic and microscopic features of this unique presentation of GS. Furthermore, we explore inflammatory mechanisms potentially responsible for the origination of the arthritic joint pathology observed in our patient.

Case presentation
We describe the rare case of a 12-year-old boy diagnosed with GS (late infantile form) who presented with multiple episodes of inflammatory arthritis involving both knees; no other joints were suspected for joint inflammation. Laboratory results did not indicate an autoimmune disorder. Synovial fluid tested negative for any bacterial infection and ruled out a malignancy and crystal-induced arthritis. Microscopic examination of the synovial tissue revealed numerous foamy macrophages with extensive vacuolization, consistent with the previous diagnosis of GS. Treatment consisted of aspiration of excessive joint fluid and subsequent intra-articular injection of triamcinolonhexacetonide with excellent but transient result. Given the evidence of storage products within macrophages of the inflamed synovial tissue and the absence of other etiological clues, GS itself was considered as the primary cause for the relapsing inflammatory joint pathology. According to the restricted data on articular manifestations in GS, to date, GS cannot be linked directly to joint inflammation. Nevertheless, in several other LSDs, the accumulation of storage material has been associated with numerous osteoimmunological changes that might play a role in the pathophysiology of arthritic processes.

Conclusions
We hypothesize that the articular build-up of GS storage products triggered systemic as well as local inflammatory processes, resulting in the extensive inflammatory joint pathology as observed in our patient. Future identification of other patients with GS is required to corroborate the existence of an arthritic clinical phenotype of GS and to assess the underlying pathophysiology.
Gastrointestinal parasites of three peri-domestic animals in selected areas in Accra, Ghana
Authors: Bimi Langbong , Yeboah Joanita Asirifi , Adongo Lucas Awane , Ofori Benjamin Yeboah , Oduro Daniel , Tetteh Ato Kwamena , Owusu Erasmus Henaku 
Published: October 2021

Abstract
Background
The rapidly increasing rodent and lizard populations in human dwellings and markets could be attributed to the destruction of their natural habitats due to rapid urbanization and poor management of urban wastes that attracts these animals. The public health concern is the potential for these animals to influence the transmission of zoonotic diseases, including helminths. In this study, the occurrence of helminth parasites in the gastrointestinal tract of rodents and lizards was determined.

Results
Of the 34 rodents, 61.8% (21/34) were observed to be infected with one (1) or more of Toxascaris sp., Isospora sp., Hymenolepis sp., Trichuris sp., Ascaris sp., or Taenia sp. Out of these, 17.6% (6/34) had single parasite infections, while 44.1% (15/34) had multiple infections of Enterobius sp., Ascaris sp., and hookworm in various combinations. Of all the Agama lizards, 54.2% (26/48) had single parasite infections compared to 18.8%, which had multiple infections. The most common parasite infection in the Agama lizards was Enterobius sp. with a mean of 7.0 ova per lizard, followed by Ascaris sp., (mean ova = 2.7) and hookworm (mean ova = 0.3) at the Legon Campus. Similarly, for Adumanya, mean ova counts were 3.9, 0.4, and 0.8, respectively, for the three helminths detected. The common parasite found in both rodents and the Agama lizards was Ascaris sp. with adults having higher burdens compared to the juveniles.

Conclusions
This study identified helminth parasites, which share the same genus as those observed to infect humans. Since these animals are ubiquitous in human dwellings and markets in Ghana, there could be a potential risk of transmission of these helminths and other disease-causing agents. We are, however, uncertain whether these agents can survive in the human digestive system to cause disease.
Psychomotor function in children with epilepsy seen at a tertiary hospital in southern Nigeria: does treatment with anti-epileptic drugs have any effect?
Authors: Ikhurionan Paul Ehiabhi , Okunola Olusola Peter , Abhulimhen-Iyoha Blessing Imuetinyan , Ofovwe Gabriel Egberue 
Published: October 2021

Abstract
Background
Psychomotor slowing is more commonly reported in children with epilepsy (CWE) compared to healthy controls. The effect of anti-epileptic drug (AED) treatment on psychomotor abilities of CWE remains controversial. In Nigeria, psychomotor abilities of CWE are scarcely investigated and the impact of AEDs is not known. The present study sought to assess psychomotor performance of CWE compared to healthy controls and to determine any association with seizure characteristics and treatment.

Method
A comparative cross-sectional study involving 160 children with idiopathic epilepsy and 80 controls aged 6–16 years. Psychomotor function was assessed using reaction times and tapping task of the Iron psychology computerised test battery. The criterion for impairment was fixed at two standard deviations (SD) worse than the mean of age-matched controls. The relationship between seizure variables and psychomotor function was assess with the one-way analysis of variance (ANOVA).

Result
Fifty-nine (36.9%) CWE had impaired auditory reaction, 50 (31.3%) with impaired visual reaction and 11 (6.9%) had fine motor control impairment. There was no significant difference in psychomotor performance between CWE on AED and the newly diagnosed counterparts yet to start AED treatment (auditory reaction time—p = 0.226; visual reaction time—p = 0.349; tapping task—p = 0.818). AED treatment duration over 5 years was associated with better auditory reaction time (F = 4.631, p = 0.034) in CWE. Also, seizure onset before 5 years of age was associated with slower auditory reaction (F = 4.912, p = 0.028) and verbal reaction (F = 14.560, p < 0.001).

Conclusion
Nigerian CWE perform less favourably on tests of psychomotor function than healthy controls. The performance of children on AED is not significantly different from those not on AED. Longer duration of AED treatment may result in psychomotor improvement in CWE. CWE should be closely monitored for psychomotor slowness so that deficits can be identified and appropriate interventions instituted.
Effect of submucosal injection of ketorolac versus dexamethasone on postoperative pain after third molar surgery: a randomized clinical trial
Authors: Hasheminia Dariush , Faghihian Reyhaneh , Mardani Farhad 
Published: October 2021

Abstract
Background
One of the most common dentoalveolar surgeries is the removal of impacted third molars. Moderate to severe pain is predictable after these surgeries, usually leaving the patient in need of an effective analgesic for at least 24 h. Corticosteroids and NSAIDs are well-known medications used to reduce pain. This prospective, randomized clinical trial aimed to assess the effectiveness of two types of analgesics, ketorolac and dexamethasone, on pain experienced after unilateral impacted third molar surgery. The analgesics were injected sublingually after profound anesthesia was confirmed in 60 healthy adult patients. During this study, the patients were divided into three groups. The patients in group K received 1 mL of ketorolac (30 mg), while the patients in group D received 1 mL of dexamethasone (4 mg) sublingually. The patients in group C (the control group) received 1 mL of normal saline solution as a placebo.

Results
The mean pain scores reported by the patients in groups K and D were significantly lower than group C (P = 0.002 and P < 0.001, respectively). However, the difference between groups D and K was not significant (P = 0.158). The mean number of analgesics taken by patients in groups K and D 24 h after surgery was significantly lower than the control group (P < 0.05). At 48 and 72 h postoperatively, however, the difference was not significant between the study groups (P > 0.05). The mean time of the first analgesic taken by the patients in groups K and D was 200.94 and 214.74 min after surgery, respectively. Exhibiting a significant difference, it was 132.65 min for the patients in group C (P = 0.003).

Conclusions
Under this study’s limitations, preoperative sublingual injection of ketorolac and dexamethasone were similarly effective in pain control after impacted third molar surgery.
Pulmonary edema in a pediatric patient undergoing ureteroscopy: a case report
Authors: Dusgun Irfan Tuna , Sahutoglu Cengiz , Balcioglu Taner 
Published: October 2021

Abstract
Background
This report demonstrates a case of pediatric pulmonary edema, detected due to the overuse of irrigation fluids during ureteroscopy.

Case presentation
A 7-year-old girl was hospitalized due to the large number of opaque stones in the right kidney. After extubation, the patient’s oxygen saturation dropped down to 85%, and respiratory distress was observed. It was determined that the surgical team used 5 Lt 0.9% NaCl solution as irrigation fluid. Positive pressure ventilation with mask continued, and intravenous bolus injection of furosemide was administered to the patient with a preliminary diagnosis of pulmonary edema.

Conclusions
In prolonged operations, patients should be checked for the presence of pulmonary edema with lung auscultation, and noninvasive mechanical ventilation and diuretic treatment should be instituted if necessary.
Quality evaluation and storage properties of traditional maize-based snacks: Ipekere Agbado enriched with Bambara groundnut
Authors: Oluwamukomi Matthew Olusola , Oluwajuyitan Timilehin David , Makinde Oluwatobiloba Tolulope 
Published: October 2021

AbstractBackgroundIpekere agbadois a traditional maize-based snack consumed in South Western part of Nigeria, but low in protein content and deteriorate within few days. Hence, this study aimed at evaluating the chemical compositions, functional properties, softness index and storage properties as influence by Bambara groundnut (BG) enrichment. Maize and Bambara groundnut flours were well mixed to generate the following blends: MB10 (Maize 90%, Bambara groundnut 10%), MB20 (Maize 80%, Bambara groundnut 20%), MB30 (Maize 70%, Bambara groundnut 30%) and CTRL (Maize 100%) which served as control.ResultsProtein value increased with increase in Bambara groundnut flour inclusion. The value obtained for Na/K and Ca/P ratio ofipekere agbadosamples including CTRL were all significantly (p < 0.05) lower than 1.00 and greater than 2.00 respectively. Low bulk density was observed in the enriched products compared with CTRL. Storage properties (TBA, PV and FFA) resulted in noticeable increase with increasing storage periods. The maize-snack stored at 37 °C had significantly (p < 0.05) shorter storage shelf life compared to those stored at 18 °C and 25 °C.ConclusionThe overall result showed that 20% Bambara substitution was the most adequate to produce an acceptable and nutritious snack (“ipekere agbado”). Hence, consumption may improve nutrient intake and reduce protein energy malnutrition menace.
Identification of plant diseases and distinct approaches for their management
Authors: Kaur Lovepreet , Sharma Shiwani Guleria 
Published: October 2021

Abstract
Background
Globally in the agricultural industry the major loss faced by is due to plant diseases. Various pathogens are responsible for causing plant bacterial and viral diseases, the treatment of them is very important in order to bring out the best quality and quantity of the agricultural yield. Before Technology came into practice the plant disease were identified by visual examination, the main symptoms such as curling of leaves and change of colour were observed. With advancements in science the microscopic examination for more clarity regarding diseases came into existence.

Main body
The distinct methods involve use of nucleic acids and serological assays were implemented to study bacterial and viral characteristics of the infecting pathogen. Traditionally, seed coating and mulching techniques were more common among farmers to generate better quality of the crops and prevent plants from any disease but currently new innovative methods are used. Microbial bio control agents are now one of the widely used approach in which microbial species are used to eliminate or inhibit the growth of pathogens in order to reduce the severity of the infection. Similarly, like microbial agent’s different chemicals are present in order to kill the pathogens. These chemicals are classified as bactericides, fungicides and nematicides which suppress the plant infection caused by bacteria, fungal and nematodes, respectively.

Conclusions
In the forthcoming years, the development of more innovative agricultural-related techniques is prime that will help in increase of the yield and provides resistance to plants. Some of them are developed earlier but there is still need to develop more pathogen-resistant species for example in case of silencing of genes with insertion of a viral segment.
Effects of different soil amendments and age of transplant on the post-harvest quality and shelf life of sweet pepper (Capsicum annuum) fruits
Authors: Addo Isaac , Santo Kwadwo Gyasi , Khalid Abdul Aziz , Ackah Emmanuel 
Published: October 2021

Abstract
Background
Two separate experiments were conducted in the minor season from September to November, 2019 and major season from March to May, 2020 to determining the type of soil amendment and transplanting age that can best improve the post-harvest quality and shelf life of sweet pepper fruits at Benso oil palm plantation of Adum Banso Estate in the Mpohor District of the Western Region of Ghana. The experiments were conducted as a 4 × 2 factorial, arranged in a Randomized Complete Block Design. Four fertilizer treatments including no fertilizer (control), 10 tons/ha of poultry manure, 300 kg/ha of NPK 15-15-15 and 5 t/ha of poultry manure + 150 kg/ha of NPK 15-15-15 and two ages of transplants including 6-week-old seedlings and 7-week-old seedlings were applied during the cultivation periods and were later evaluated of their effects on the post-harvest quality and shelf life of harvested fruits after a two-weeks storage period. Data collected on weight loss, shrinkage, decayed fruits and shelf life of harvested fruits were subjected to analysis of variance using the Genstat Statistical package. The least significant difference criterion was used to separate treatment means at 5% probability.

Results
Post-harvest qualities of sweet pepper fruits were not significantly influenced by age of transplant throughout the study. Fertilizer application generally increased percentage fruit weight loss, fruit shrinkage, fruit decay and reduced shelf life of sweet pepper fruits in the major season. Sole application of poultry manure mostly enhanced post-harvest quality of sweet pepper fruits in the minor rainy season, but fruit shelf life was improved if no fertilizer was applied. Application of a combination of poultry manure and NPK 15-15-15 to 6-week-old transplants gave relatively low fruit weight loss and shrinkage values. Generally, fruit quality and shelf life were enhanced in 6-week-old transplants treated with no fertilizer.

Conclusions
The use of poultry manure alone should be encouraged to probably increase yield while improving the quality and shelf life of harvested sweet pepper fruits. Transplanting of 6-week-old seedlings is also encouraged for quality harvested fruits and extended shelf life.
Chemo-informatics activity prediction, ligand based drug design, Molecular docking and pharmacokinetics studies of some series of 4, 6-diaryl-2-pyrimidinamine derivatives as anti-cancer agents
Authors: Abdullahi Sagiru Hamza , Uzairu Adamu , Ibrahim Muhammad Tukur , Umar Abdullahi Bello 
Published: October 2021

AbstractBackgroundThe most well-known cause of cancer deaths identified in female is breast cancer. Several drugs approved by the food and drug administration (FDA) for the treatment of breast cancer may have adverse health effects. This research is aimed at developing a QSAR model and utilize it to predict the inhibitive activities of newly designed novel compounds, examine their ADMET and drug-likeness properties and carry out molecular docking studies between the designed compounds and the VEGFR-2 receptors in order to identify the essential amino acid residues involved in protein–ligand interactions and possible mechanism of action of the designed compounds.ResultsThe first model was selected as the best because of its fitness statistically with the following assessment parameters:R2train = 0.832,R2adj = 0.79,R2ext = 0.62,Q2 = 0.68, and LOF = 0.14509. Compound 11 was selected as a template to design new powerful compounds based on its low residual and high pIC50values. Majority of the designed compounds has predicted pIC50greater than that of the lead compound and the standard drug (Sunitinib) used as reference. Molecular docking studies results of the designed compounds revealed that they have higher docking scores than the template and the reference drug (Sunitinib) and are found to bind to the VEGFR-2 receptor in a similar manner to the reference drug. Pharmacokinetics and ADMET properties revealed that the designed compounds passed drug-likeness criteria because they did not violate more than 1 Lipinski’s rule of Five, They are uniformly distributed to the brain and are assumed to penetrate the central nervous system and finally they are all found to non-toxic and orally bioavailable.ConclusionThe developed model was therefore found to be efficient in predicting the pIC50of Anti breast cancer compounds that are yet to be synthesized and it also help in reducing the cost and synthetic duration the compounds. The result of this research confirmed that the designed compounds may be developed as novel VEGFR-2 inhibitors.
Chemotherapeutic drugs in Lebanese surface waters: estimation of population exposure and identification of high-risk drugs
Authors: Saab Yolande , Nakad Zahi , Rahme Rita 
Published: October 2021

AbstractEnvironmental risks imposed by anti-cancer drugs and their degradation products are a major concern worldwide. The consumption of anticancer drugs is increasing throughout the years and conventional water treatment processes seem to be ineffective for their removal. The aim of this study is to analyze the consumption of anticancer drugs in Lebanon and assess their potential health hazard as contaminants of the Lebanese surface waters. Anticancer drugs consumption data between the years 2013 and 2018 were collected and the following parameters were calculated: yearly consumption of single active ingredients, yearly consumption of drug equivalents (for drugs belonging to the same pharmacologic class having the same active ingredient) and Predicted Environmental Concentrations (PECs). The obtained PEC values were used to stratify compounds into risk categories. The top five most commonly consumed drugs are Mycophenolate mofetil, Hydroxycarbamide, Capecitibine, Mycophenolic acid and Azathioprine. Based on the calculated PEC values of single active ingredients as well as their equivalents, six high-risk priority compounds were identified: Mycophenolate mofetil, Hydroxycarbamide, Capecitibine, Mycophenolic acid, Azathioprine and 5-Fluorouracil. The impact of these micropollutants on animals as well as humans was analyzed. This research stresses the importance of further analysis of chemotherapy micropollutants with major focus on high-risk drugs. Additionally, regulations should be set in place to ensure proper management of wastewater and the development of efficient wastewater treatment plants.
Graft tunnel integration occurs early in the tibial tunnel compared with the femoral tunnel after anterior cruciate ligament reconstruction with preserved insertion hamstring tendon graft
Authors: Gupta Ravi , Singh Sandeep , Kapoor Anil , soni Ashwani , Kaur Ravinder , Kaur Narinder 
Published: October 2021

Abstract
Background
Preservation of hamstring tendon insertion at the time of anterior cruciate ligament (ACL) reconstruction is a well-known technique; however, its effect on graft integration is not well studied. The present study was conducted to study the graft integration inside the tibial and femoral tunnels, respectively, after ACL reconstruction using hamstring tendon graft with preserved insertion.

Methods
Twenty-five professional athletes who underwent ACL reconstruction using hamstring tendon graft with preserved tibia insertion were enrolled in the study. Functional outcomes were checked at final follow-up using Lysholm score and Tegner activity scale. Magnetic resonance imaging (MRI) was done at 8 months and 14 months follow-up to study the graft tunnel integration of the ACL graft at both tibial and femoral tunnels.

Results
The mean Fibrous interzone (FI) score (tibial tunnel) decreased from 2.61 (1–5) at 8 months to 2.04 (1–4) at 14 months follow-up (p = 0.02). The mean FI score (femoral side) decreased from 3.04 (2–5) at 8 months to 2.57 (2–4) at 14 months (p = 0.02).

Conclusions
Graft integration occurs early in the tibial tunnel as compared with the femur tunnel with preserved insertion hamstring tendon autograft.
Trial registration CTRI/2019/07/020320 [registered on 22/07/2019]; http://www.ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=33884&EncHid=&modid=&compid=%27,%2733884det%27