bluuebunny/crossref_metadata_2025_split huggingface dataset:
Region specificity of rheumatoid foot symptoms associated with ultrasound-detected synovitis and joint destruction
Authors: Ishie Shinichiro , Ito Hiromu , Nakabo Shuichiro , Tsuji Hideaki , Nakajima Toshiki , Tsuji Yuko , Inagaki Maiko , Furu Moritoshi , Hashimoto Motomu , Murata Koichi , Murakami Kosaku , Nishitani Kohei , Tanaka Masao , Fujii Yasutomo , Matsuda Shuichi 
Published: April 2021

Abstract

Objectives
We aimed to clarify the clinical implication of ultrasound (US)-detected foot joint inflammation in tightly controlled patients with rheumatoid arthritis (RA).

Methods
We evaluated bilateral foot joints (second to fifth metatarsophalangeal joints of forefoot; tarsometatarsal, cuneonavicular and midtarsal joints of midfoot) of 430 RA patients for synovitis using Power Doppler (PD) imaging by US. We made a cross-sectional and a 3-year longitudinal analysis about the associations of US-detected synovitis with clinical, laboratory and radiographic data as well as foot-specific outcomes using a self-administered foot evaluation questionnaire (SAFE-Q).

Results
The US-detected foot synovitis was seen in 28% of patients. The US-detected synovitis was closely related to 28 joint-disease activity score (DAS28) more in the forefoot than in the midfoot, while related to joint destruction in both. Multiple regression analyses showed significant associations between midfoot PD positivity and SAFE-Q in the remission group. SAFE-Q was worsened after the 3-year interval, but PD positivity at baseline did not contribute to the changes. On the other hand, destruction of the joints with US-detected synovitis significantly progressed in 3 years than with not.

Conclusions
US-detected synovitis on foot joints were related to systemic inflammation, clinical symptoms, and future joint destruction with region specificity.
Systematic review for the treatment of older rheumatoid arthritis patients informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis
Authors: Sugihara Takahiko , Kawahito Yutaka , Morinobu Akio , Kaneko Yuko , Seto Yohei , Kojima Toshihisa , Ito Hiromu , Kohno Masataka , Nakayama Takeo , Sobue Yasumori , Nishida Keiichiro , Matsushita Isao , Murashima Atsuko , Mori Masaaki , Tanaka Eiichi , Hirata Shintaro , Kishimoto Mitsumasa , Yamanaka Hisashi , Kojima Masayo , Harigai Masayoshi 
Published: April 2021

Abstract

Objectives
To provide an evidence base for clinical practice guidelines (CPG) for the management of rheumatoid arthritis (RA) in older adults.

Methods
PubMed, Cochrane library, and Japan Centra Revuo Medicina databases were searched for articles published between 1990 and 2019. Quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation system, with some modifications.

Results
Among 702 identified articles, there were 5 post-hoc analyses of randomized controlled trials and 10 observational studies. Meta-analysis of the former yielded a mean difference of the van der Heijde-modified total Sharp score of −2.79 (95% confidence interval [CI] − 3.74 to −1.84) for treatment with tumor necrosis factor inhibitors. The risk ratio (RR) for the American College of Rheumatology 50% response rate, and for serious adverse events was 2.83 (95%CI 1.90–4.21) and 1.32 (95%CI 0.53–3.31), respectively, for Janus kinase inhibitors. Meta-analysis of the observational studies yielded an RR for disease activity score-28 remission and serious infections of 0.76 (95%CI 0.64–0.91) and 1.92 (95%CI 1.31–2.81) for older-versus-younger patients receiving biological disease-modifying antirheumatic drugs, respectively.

Conclusion
This systematic review provides the necessary evidence for developing CPG for the management of RA in older adults.
Patients’ perspectives of rheumatoid arthritis treatment: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines
Authors: Kojima Masayo , Hasegawa Mieko , Hirata Shintaro , Ito Hiromu , Kaneko Yuko , Kishimoto Mitsumasa , Kohno Masataka , Kojima Toshihisa , Matsushita Isao , Mori Masaaki , Morinobu Akio , Murashima Atsuko , Nishida Keiichiro , Seto Yohei , Sobue Yasumori , Sugihara Takahiko , Tanaka Eiichi , Nakayama Takeo , Kawahito Yutaka , Harigai Masayoshi 
Published: April 2021

AbstractObjectivesThis study aimed to evaluate patients’ opinions regarding their rheumatoid arthritis (RA) therapy and to reflect the patients’ perspectives in the 2020 update of the Japan College of Rheumatology clinical practice guidelines.MethodsA self-administered questionnaire was mailed to 1600 members of the Japan Rheumatology Friendship Association, who were randomly selected by age and prefecture.ResultsA total of 1156 patients returned the questionnaire (response rate, 72.3%; mean age, 63.0 ± 11.9 years). Those who reported having discussed their treatment goals with their doctors (450 respondents, 38.9%) were more likely to be satisfied with their current medical care (odds ratio, 7.13; 95% CI 4.72–10.8) compared with those who had not discussed their goals nor had them explained (287 respondents, 24.8%). The benefits exceeded the adverse effects for all pharmacotherapy (methotrexate, corticosteroids, conventional synthetic antirheumatic drugs, biological agents, Janus kinase inhibitor, and anti-RANKL antibodies). However, while 74.2% of the respondents using biological agents perceived that ‘the favorable aspects outweighed the unfavorable aspects,’ most of those taking anti-RANKL antibodies (69.2%) felt uncertain.ConclusionsThe questionnaire successfully collected information regarding patients’ perceptions regarding their therapy. Further implementation of treat-to-target is necessary in Japan to improve patient satisfaction.
Comprehensive risk analysis of postoperative complications in patients with rheumatoid arthritis for the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis
Authors: Ito Hiromu , Murata Koichi , Sobue Yasumori , Kojima Toshihisa , Nishida Keiichiro , Matsushita Isao , Kawahito Yutaka , Kojima Masayo , Hirata Shintaro , Kaneko Yuko , Kishimoto Mitsumasa , Kohno Masataka , Mori Masaaki , Morinobu Akio , Murashima Atsuko , Seto Yohei , Sugihara Takahiko , Tanaka Eiichi , Nakayama Takeo , Harigai Masayoshi 
Published: April 2021

Abstract

Objectives
To examine the risk factors of surgical site infection (SSI), delayed wound healing, and death after orthopedic surgery in patients with rheumatoid arthritis (RA).

Methods
We identified articles indexed in the Cochrane Library, PubMed, and Japan Centra Revuo Medicina Web published from 2013 to 2019 and other articles. Articles fulfilling the predefined inclusion criteria were reviewed systematically and their quality was appraised according to the Grading of Recommendations Assessment, Development, and Evaluation system with some modifications.

Results
After inclusion and exclusion by full-text review, 29 articles were analyzed. Use of biological disease modifying antirheumatic drugs was a risk factor of SSI (risk ratio 1.66, 95% confidence interval 1.25–2.19), but not of delayed wound healing. RA itself was a risk factor of SSI, and oral glucocorticoid use was a risk factor of SSI in three of the four studies analyzed and of postoperative death. Age, male sex, comorbidities such as diabetes mellitus and chronic obstructive pulmonary disease, surgical factors such as foot/ankle and spine surgery and longer operative time were risk factors of those postoperative complications.

Conclusion
Patients with those factors should be dealt with appropriate cautions to strike a risk–benefit balance of orthopedic surgeries.
On the stability and accuracy of the empirical interpolation method and gravitational wave surrogates
Authors: Tiglio Manuel , Villanueva Aarón 
Published: April 2021

Abstract
The combination of the reduced basis and the empirical interpolation method (EIM) approaches have produced outstanding results in many disciplines. In particular, in gravitational wave (GW) science these results range from building non-intrusive surrogate models for GWs to fast parameter estimation adding the use of reduced order quadratures. These surrogates have the salient feature of being essentially indistinguishable from or very close to supercomputer simulations of the Einstein equations, but can be evaluated in the order of a millisecond per multipole mode on a standard laptop. In this article we clarify a common misperception of the EIM as originally introduced and used in practice in GW science. Namely, we prove that the EIM at each iteration chooses the interpolation nodes so as to make the related Vandermonde-type matrix as invertible as possible; not necessarily optimizing its conditioning or accuracy of the interpolant as is sometimes thought. In fact, we introduce two new variations of the EIM, nested as well, which do optimize with respect to conditioning and the Lebesgue constant, respectively, and compare them through numerical experiments with the original EIM using GWs. Our analyses and numerical results suggest a subtle relationship between solving for the original EIM, conditioning, and the Lebesgue constant, in consonance with active research in rigorous approximation theory and related fields.
Three-body inertia tensor
Authors: Ee June-Haak , Jung Dong-Won , Kim U-Rae , Kim Dohyun , Lee Jungil 
Published: April 2021

Abstract
We derive a general formula for the inertia tensor of a rigid body consisting of three particles with which students can learn basic properties of the inertia tensor without calculus. The inertia-tensor operator is constructed by employing the Dirac’s bra-ket notation to obtain the inertia tensor in an arbitrary frame of reference covariantly. The principal axes and moments of inertia are computed when the axis of rotation passes the center of mass. The formulas are expressed in terms of the relative displacements of particles that are determined by introducing Lagrange’s undetermined multipliers. This is a heuristic example analogous to the addition of a gauge-fixing term to the Lagrangian density in gauge field theories. We confirm that the principal moments satisfy the perpendicular-axis theorem of planar lamina. Two special cases are considered as pedagogical examples. One is a water-molecule-like system in which a particle is placed on the vertical bisector of two identical particles. The other is the case in which the center of mass coincides with the incenter of the triangle whose vertices are placed at the particles. The principal moment of the latter example about the normal axis is remarkably simple and proportional to the product ‘abc’ of the three relative distances. We expect that this new formula can be used in actual laboratory classes for general physics or undergraduate classical mechanics.
A pedagogical introduction to the Schwinger variational principle: an application to low energy positron-atom scattering
Authors: Seidel Eliton Popovicz , Arretche Felipe 
Published: April 2021

Abstract
We present a pedagogical introduction to the Schwinger variational principle. As a model problem, we consider the low energy positron-atom scattering in the static approximation. The mathematical aspects and physical assumptions of the method, with attention to the construction and selection of trial scattering basis sets, are discussed in detail. Emphasis is given in the numerical implementation, usually neglected in scattering textbooks where the Schwinger variational principle is presented. Issues of convergence, phase shifts, scattering lengths and elastic cross sections are presented for positron-hydrogen and positron-krypton scattering.
Triple plasmon-induced transparency in graphene and metal metamaterials and its anomalous property
Authors: Zhang Xiao , Liu Zhimin , Zhang Zhenbin , Qin Yipeng , Zhuo Shanshan , Luo Xin , Zhou Fengqi , Yi Zao , Wang Jiawei , Wang Yuqing 
Published: April 2021

Abstract
A silicon-graphene-silica periodic graphene metamaterial, comprising of a graphene-strip, graphene-block, and graphene-ribbon, is proposed to realize dynamic triple plasmon-induced transparency (PIT). Coupled mode theory is employed to explain this phenomenon, and the results are in close agreement with the finite-difference time-domain simulation. It is interesting to note that the triple-PIT can also be realized by using silver instead of graphene and silicon layer. When the Fermi level of the graphene is 0.75 eV, the difference of the triple-PIT based on the two structure types is easily analyzed because the resonant frequencies are effectively coincident. As a result, the structure of graphene exhibits better absorption characteristics compared with that of silver, however, it decreases with increasing Fermi levels within graphene. Thus, the higher Fermi level of graphene is not suitable for the absorbers. Furthermore, the anomalous property of graphene triple-PIT that is attributed to the interaction way of the dark mode differing from the bright mode is analyzed compared with the silver triple-PIT, and it can be used to compensate for the defects of silver PIT. This study is significant for the absorber for which the graphene is utilized. The insights gained from the comparison between metal and graphene are crucial to the design of the metamaterials for which graphene and metal are used.
Coarse grained simulation of the aggregation and structure control of polyethylene nanocrystals
Authors: Flachmüller Alexander , Mecking Stefan , Peter Christine 
Published: April 2021

Abstract
Polyethylene (PE) telechelics with carboxylate functional groups at both ends have been shown to assemble into hexagonal nanocrystal platelets with a height defined by their chain length in basic CsOH-solution. In this coarse grained (CG) simulation study we show how properties of the functional groups alter the aggregation and crystallization behavior of those telechelics. Systematic variation of the parameters of the CG model showed that important factors which control nanoparticle stability and structure are the PE chain length and the hydrophilicity and the steric demand of the head groups. To characterize the aggregation process we analyzed the number and size of the obtained aggregates as well as intramolecular order and intermolecular alignment of the polymer chains. By comparison of CG and atomistic simulation data, it could be shown that atomistic simulations representing different chemical systems can be emulated with specific, different CG parameter sets. Thus, the results from the (generic) CG simulation models can be used to explain the effect of different head groups and different counterions on the aggregation of PE telechelics and the order of the obtained nanocrystals.
The effect of barrier layers on 2D electron effective mass in Al0.3Ga0.7N/AlN/GaN heterostructures
Authors: Sonmez F , Ardali S , Lisesivdin S B , Malin T , Mansurov V , Zhuravlev K , Tiras E 
Published: April 2021

Abstract
The Shubnikov de Haas (SdH) effect measurements have been performed to evaluate the influence of Si3N4 passivation, a spacer layer, and Si-doped barrier layer on the electronic transport parameters of two-dimensional (2D) electrons in Al0.3Ga0.7N/AlN/GaN heterostructures under temperatures from 1.8 K to 40 K and at a magnetic field up to 11 T. The 2D electron effective mass (m*), 2D carrier density (N
2D), the difference between Fermi level and subband energy levels (E
F − E
1), quantum lifetime (τ
q) are determined by analyzing SdH oscillations. Although investigated samples with equal 2D electron density are examined, the effective mass values of 2D electrons are deduced within the range of (0.16 ± 0.005)m
0 and (0.23 ± 0.005)m
0. Results reveal that passivation, a spacer layer, and doping affect 2D electron effective mass. Furthermore, the dominant scattering mechanisms that limited electron transport is determined as a long-range scattering for all investigated sample. The results obtained provide information for the high-performance device application of these samples.
Priority issues and key findings from evaluation of disposal records for a legacy radioactive waste site
Authors: Payne Timothy E , Shatwell Jonathan , Comarmond M Josick 
Published: April 2021

Abstract
This paper reports on a detailed investigation into the disposal procedures and records from the operational period (1960–1968) of the Little Forest Legacy Site (LFLS) in eastern Australia. The aims of the paper are firstly, to highlight the priority issues which are relevant to the radiological assessment of the LFLS, and secondly, to present key lessons that may help to guide future investigations of the records at similar sites. Particular effort was put into assessing the various types of relevant documents and the relationships between them. A specific objective of this work was to evaluate an inventory of the wastes which was reported shortly after the time of disposals. A major finding of the study is that the original actinide inventory for LFLS relied solely on estimates from a limited number of specific records known as ‘Scrap Disposal Reports’ (SDRs). For example, the estimated amount of plutonium disposed at the LFLS was based on only seven SDR records. Given that there are approximately 50000 buried items, it is possible that other Pu-contaminated items could make a significant additional contribution to the amount of Pu present at the site. For some waste components (e.g. beryllium) the documentation shows that rough estimates of disposal quantities were made, based on the number of disposed Be-contaminated items in each trench. The use of such approximations casts some doubt on the accuracy of the previous inventory of wastes at the site. In addition, the early summaries of radionuclide disposals, which categorized radionuclides into groups according to their radiological hazard, contained significant underestimates of the radionuclide inventory in the most hazardous category (referred to at the time as ‘Group I’ radionuclides). This was mainly due to the omission of the Pu (which had been recorded on the SDRs) from the Group I inventory, but was also in part because the Group I radionuclide content of disposed sludge drums (from a wastewater treatment plant) was not taken into account for most of the disposal period. Establishing the disposal history and radionuclide inventory at legacy sites is an important pre-requisite to evaluating their radiological impact and developing management options. The detailed investigation of the LFLS records shows the importance of understanding the operational practices of the period and the derivation of the original inventories. These insights should help guide future efforts to better understand disposal histories and inventories at LFLS and elsewhere.
Adaptive sparse denoising and periodicity weighted spectrum separation for compound bearing fault diagnosis
Authors: Meng Jing , Wang Hui , Zhao Liye , Yan Ruqiang 
Published: April 2021

Abstract
The compound fault diagnosis of rolling bearings has become a hot topic. In this study, a novel method based on adaptive sparse denoising (ASD) combined with periodicity weighted spectrum separation (PWSS) is proposed to diagnose compound faults in rolling bearings. Specifically, ASD reveals fault types and PWSS separates compound faults. First, ASD determines regularization parameters adaptively using the proposed compound frequency multi D-norm, thereby denoising the raw vibration signal and revealing fault types. Then, PWSS constructs the time-frequency spectrum (TFS) and uses the fault periodicity from ASD to determine the time occurrence positions of the repetitive impulses. With this time occurrence position information, a weight matrix is constructed to reweight the TFS. Finally, through the reweighted TFS, PWSS extracts and separates repetitive impulses from compound faults. The performance of the proposed method is validated in both simulation and experimental studies. The results demonstrate that the proposed method can successfully diagnose and separate the compound faults.
Linear phase delay detection method for optical voltage transformer based on S-wave plate
Authors: Xie Nan , Zhu Defeng , Xu Qifeng , Tan Qiao 
Published: April 2021

Abstract
To achieve linear measurement of electro-optic phase delay and improve the accuracy and measurement range of the optical voltage transducer (OVT), this paper proposes a linear phase delay detection method for an optical voltage transformer based on a strip S-wave plate. Using the strip S-wave plate, the phase delay can be directly converted into the displacement of the dark stripe of the strip spot, and the displacement is located by the dual-quadrant detector. Using the Jones matrix, we confirm the linear relationship between the position of the dark stripe and the phase delay, and propose a positioning method and error compensation scheme of the dark stripe and set up an experimental system to verify its performance. The experimental results show that the OVT realizes the measurement of the electro-optic phase delay; the measuring range of the phase delay is up to ±40°, and the measurement error is less than 0.5%.
Tightly-bound trion and bandgap engineering via γ-ray irradiation in the monolayer transition metal dichalcogenide WSe2
Authors: Wu Xiongli , Zheng Xuejun , Zhang Guangbiao , Chen Xinnan , Ding Jianwen 
Published: April 2021

Abstract
After γ-ray irradiation treatment, a monolayer tungsten diselenide could be transitioned into an n-doped semiconductor due to the anion vacancies created by the radiation. Transmission electron microscope studies showed clear chemical modulation with atomically sharp interface. Change in the lattice vibrational modes induced by passivation of oxygen is captured by Raman spectroscopy. The frequency shifts in both in-plane and out-of-plane modes are dependent linearly on the oxidation content. We observe a negative trion, which is a neutral exciton bound with an electron, in the photoluminescence spectra. The binding energy of this trion is estimated to be ∼90 meV, making it a tightly bound exciton. The first-principles calculation suggests that an increase in the anion vacancy population is generally accompanied by a transition from a direct gap material to an indirect one. This opens up a new venue to engineer the electronic properties of transition metal dichalcogenides by using irradiation.
MOF derived double-carbon layers boosted the lithium/sodium storage performance of SnO2 nanoparticles
Authors: Zhu Shaoqing , Huang Aoming , Wang Qian , Xu Ye 
Published: April 2021

Abstract
Tin oxide (SnO2) was considered as a promising alternative to commonly used graphite anode in energy storage devices thanks to its superior specific capacity. However, its electrochemical property was severely limited due to the inherent poor conductivity and drastic volume variation during the charging/discharging process. To overcome this disadvantage, we grew Sn-MOF directly on graphene oxide (GO) layers to synthesize a double carbon conductive network-encapsulated SnO2 nanoparticles (SnO2/C/rGO) via a facile solvothermal method. During the process, Sn-MOF skeleton transformed into porous carbon shells, in which nanosized SnO2 particles (~8nm) were embedded, while GO template was reduced to highly conductive rGO layer tightly wrapping the SnO2/C particles. This double-carbon structure endowed SnO2/C/rGO anode with enhanced specific capacity and rate property both in lithium ion batteries (LIB) and sodium ion batteries (SIB). The SnO2/C/rGO anode showed a highly reversible specific capacity of 1038.3 mAh g−1 at 100 mA g−1, and maintained a stable capacity of 720.2 mAh g−1 (70.1%) under 500 mA g−1 after 150 cycles in LIBs. Similarly, highly reversible capacity of 350.7 mAh g−1 (81.1%) under 100 mA g−1 after 150 cycles was also achieved in SIBs. This work provided a promising strategy in improving the electrochemical properties of SnO2 nanoparticles (NPs), as well as other potential anode materials suffering from huge volume change and poor conductivity.