bluuebunny/crossref_metadata_2025_split huggingface dataset:
An advanced multipole model for (216) Kleopatra triple system
Authors: Brož M. , Marchis F. , Jorda L. , Hanuš J. , Vernazza P. , Ferrais M. , Vachier F. , Rambaux N. , Marsset M. , Viikinkoski M. , Jehin E. , Benseguane S. , Podlewska-Gaca E. , Carry B. , Drouard A. , Fauvaud S. , Birlan M. , Berthier J. , Bartczak P. , Dumas C. , Dudziński G. , Ďurech J. , Castillo-Rogez J. , Cipriani F. , Colas F. , Fetick R. , Fusco T. , Grice J. , Kryszczynska A. , Lamy P. , Marciniak A. , Michalowski T. , Michel P. , Pajuelo M. , Santana-Ros T. , Tanga P. , Vigan A. , Vokrouhlický D. , Witasse O. , Yang B. 
Published: May 2021

Aims.To interpret adaptive-optics observations of (216) Kleopatra, we need to describe an evolution of multiple moons orbiting an extremely irregular body and include their mutual interactions. Such orbits are generally non-Keplerian and orbital elements are not constants.Methods.Consequently, we used a modifiedN-body integrator, which was significantly extended to include the multipole expansion of the gravitational field up to the orderℓ= 10. Its convergence was verified against the ‘brute-force’ algorithm. We computed the coefficientsCℓm,Sℓmfor Kleopatra’s shape, assuming a constant bulk density. For Solar System applications, it was also necessary to implement a variable distance and geometry of observations. Ourχ2metric then accounts for the absolute astrometry, the relative astrometry (second moon with respect to the first), angular velocities, and silhouettes, constraining the pole orientation. This allowed us to derive the orbital elements of Kleopatra’s two moons.Results.Using both archival astrometric data and new VLT/SPHERE observations (ESO LP 199.C-0074), we were able to identify the true periods of the moons,P1= (1.822359 ± 0.004156) d,P2= (2.745820 ± 0.004820) d. They orbit very close to the 3:2 mean-motion resonance, but their osculating eccentricities are too small compared to other perturbations (multipole, mutual), meaning that regular librations of the critical argument are not present. The resulting mass of Kleopatra,m1= (1.49 ± 0.16) × 10−12M⊙or 2.97 × 1018kg, is significantly lower than previously thought. An implication explained in the accompanying paper is that (216) Kleopatra is a critically rotating body.
Ocular Involvement in COVID-19: Conjunctivitis and More
Authors: Rokohl Alexander C. , Grajewski Rafael S. , Matos Philomena A. Wawer , Kopecky Adam , Heindl Ludwig M. , Cursiefen Claus 
Published: May 2021

AbstractSince the beginning of 2020, SARS-CoV-2, the pathogen of COVID-19, has led to a global pandemic that also affects ophthalmology. Ophthalmologists can be confronted at any time with potentially COVID-19 associated ocular symptoms or manifestations in patients and also become infected through close patient contact. Even without systemic infection, the ocular surface can come into direct contact with aerosols or liquids containing SARS-CoV-2 particles. A smear infection through hand-to-eye contact is also possible. A purely isolated ocular infection has not yet been shown. Rather, it seems that ocular complications occur in the context of a systemic infection. However, ocular symptoms can also be the first symptom of COVID-19. The most common ocular complication of COVID-19 is mild follicular conjunctivitis. Haemorrhagic conjunctivitis, dry eye disease, episcleritis, or retinal involvement can also occur less frequently. There are currently no evidence-based therapy
recommendations for COVID-19 associated diseases of the ocular surface. Artificial tears might be helpful for symptom relief. There is no evidence for antiviral, antibiotic, or anti-inflammatory therapies, but these medications might be used in individual cases. Potential intraocular complications include retinal artery occlusions and haemorrhages, as well as cotton wool spots caused by complement-mediated thrombotic angiopathy. Neuro-ophthalmological complications including Miller-Fisher syndrome or infarct-related central blindness can also occur in very rare cases. Knowledge of potential transmission routes and personal protective equipment is just as essential for each ophthalmologist as a basic knowledge of potential ocular symptoms and complications.
Mechanistic Evaluation of Linalool Effect against Renal Ischemia- Reperfusion Injury in Rats
Authors: Golmohammadi Mohammad-Ghasem , Banaei Shokofeh , Azimian Ehsan 
Published: May 2021

Abstract
Background Kidney ischemia reperfusion (IR) is an important cause of renal dysfunction. The hypoxic conditions in ischemic damage result in the formation of free radicals and apoptotic death of renal cells. We evaluated the renoprotective effects of linalool in IR- induced renal injury.
Methods Wistar rats were divided into three groups of six rats; namely, control group, IR group, and linalool + IR group. The animals were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 24 h reperfusion. Linalool (40mg/kg) was administered before ischemia. After 24h reperfusion, the kidney tissues were obtained for detection of miR-21, HSP 70 and caspase-3 expression levels and histological studies. Also, the blood samples were collected for the measurement of biochemical parameters.
Results IR significantly increased the expression of miR-21, HSP70 and capase-3 and the serum levels of BUN-Cr, ALT, AST and ALP enzymes. Furthermore, histological findings of the IR group confirmed that there were acute tubular necrosis and lymphocyte infiltration in the renal tissues. Treatment with linalool improved the renal function and morphological changes.
Conclusion It seems that linalool could exert a nephroprotective effect via a number of mechanisms in renal IR injury.
Evaluation of Cocoa Bean Shell Antimicrobial Activity: A Tentative Assay Using a Metabolomic Approach for Active Compound Identification
Authors: Rojo-Poveda Olga , Ribeiro Sofia Oliveira , Anton-Sales Cèlia , Keymeulen Flore , Barbosa-Pereira Letricia , Delporte Cédric , Zeppa Giuseppe , Stévigny Caroline 
Published: May 2021

AbstractCocoa bean shell is one of the main by-products of chocolate manufacturing and possesses several compounds with biofunctionalities. It can function as an antibacterial agent, and its action is mostly reported against Streptococcus mutans. However, only a few studies have investigated the cocoa bean shell compounds responsible for this activity. This study aimed to evaluate several extracts of cocoa bean shells from different geographical origins and cocoa varieties and estimate their antimicrobial properties against different fungal and bacterial strains by determining their minimal inhibitory concentration. The results demonstrated antimicrobial activity of cocoa bean shell against one of the tested strains, S. mutans. Cocoa bean shell extracts were further analysed via LC-HRMS for untargeted metabolomic analysis. LC-HRMS data were analysed (preprocessing and statistical analyses) using the Workflow4Metabolomics platform. The latter enabled us to identify
possible compounds responsible for the detected antimicrobial activity by comparing the more and less active extracts. Active extracts were not the most abundant in polyphenols but contained higher concentrations of two metabolites. After tentative annotation of these metabolites, one of them was identified and confirmed to be 7-methylxanthine. When tested alone, 7-methylxanthine did not display antibacterial activity. However, a possible cocktail effect due to the synergistic activity of this molecule along with other compounds in the cocoa bean shell extracts cannot be neglected. In conclusion, cocoa bean shell could be a functional ingredient with benefits for human health as it exhibited antibacterial activity against S. mutans. However, the antimicrobial mechanisms still need to be confirmed.
Intraperitoneal Activation of Coagulation and Fibrinolysis in Patients with Cirrhosis and Ascites
Authors: Thaler Johannes , Lisman Ton , Quehenberger Peter , Hell Lena , Schwabl Philipp , Scheiner Bernhard , Bucsics Theresa , Nieuwland Rienk , Ay Cihan , Trauner Michael , Pabinger Ingrid , Reiberger Thomas , Mandorfer Mattias 
Published: May 2021

AbstractDevelopment of ascites is the most common form of decompensation of cirrhosis. We aimed to investigate the coagulation system in ascitic fluid and plasma of patients with cirrhosis. We determined coagulation parameters and performed clotting and fibrinolysis experiments in ascitic fluid and plasma of thoroughly characterized patients with cirrhosis and ascites (n = 25) and in plasma of patients with cirrhosis but without ascites (n = 25), matched for severity of portal hypertension. We also investigated plasma D-dimer levels in an independent cohort of patients (n = 317) with clinically significant portal hypertension (HVPG ≥ 10 mmHg), grouped according to ascites severity. Ascitic fluid was procoagulant in a clotting assay. The procoagulant potential of ascitic fluid was abolished by depletion of extracellular vesicles from ascitic fluid by filtration or by addition of a tissue factor-neutralizing antibody. Compared with plasma, extracellular vesicle-associated tissue factor activity was high in ascitic fluid, while activities of other coagulation factors were low. The extracellular vesicle-depleted fraction of ascitic fluid induced fibrinolysis, which was prevented by aprotinin, indicating the presence of plasmin in ascitic fluid. Plasma peak thrombin generation and parameters reflecting fibrinolysis were independently associated with the presence of ascites. Finally, plasma D-dimer levels were independently linked to ascites severity in our second cohort comprising 317 patients. In conclusion, coagulation and fibrinolysis become activated in ascites of patients with cirrhosis. While tissue factor-exposing extracellular vesicles in ascitic fluid seem unable to pass the peritoneal membrane, fibrinolytic enzymes get activated in ascitic fluid and may re-enter the systemic circulation and induce systemic fibrinolysis.
Psychomotor Delay in a Child with FGFR3 G380R Pathogenic Mutation Causing Achondroplasia
Authors: Ergoren Mahmut C. , Eren Erdal , Manara Elena , Paolacci Stefano , Tulay Pinar , Sag Sebnem O. , Bertelli Matteo , Mocan Gamze , Temel Sehime Gulsun 
Published: May 2021

AbstractAchondroplasia (ACH) is a hereditary disorder of dwarfism that is caused by the aberrant proliferation and differentiation of chondrocyte growth plates. The common findings of macrocephaly and facial anomalies accompany dwarfism in these patients. Fibroblast growth factor receptor 3 (FGFR3) gene mutations are common causes of achondroplasia. The current study presents a case of 2-year-old male child patient presenting with phenotypic characteristics of ACH. The interesting finding of the case is the presence of psychomotor delay that is not very common in these patients. Clinical exome sequencing analyzing 4.813 disease causing genes revealed a de novo c.1138G > A mutation within the FGFR3 gene. In conclusion, the mutation confirms the clinical diagnosis of ACH, and it seems to be causing the psychomotor delay in this patient.
Clinical Picture, Outcome, and Risk of Serious Bacterial Infections in Immunocompetent Previously Healthy Neutropenic Children
Authors: Arslantaş Esra , Ayçiçek Ali , Türkoğlu Recep , Tahtakesen Tuba Nur , Uysalol Ezgi Paslı , Bayram Cengiz , Akici Ferhan , Şanlı Kamuran , Özdemir Nihal 
Published: May 2021

Abstract
Objective In childhood, the cause of neutropenia is a challenging diagnosis with a spectrum of underlying etiologies. This study was performed to investigate the clinical picture and the outcomes associated with the new onset neutropenia in previously healthy children, and to determine the risk of serious bacterial infection (SBI) in those patients.
Methods Patients presenting between January 2018 and September 2018 with an absolute neutrophil count (ANC) <1,500/μL were retrospectively evaluated. Patients with known underlying chronic disease or immunosuppressive conditions were excluded. Neutropenia was categorized into three groups: mild, 1,000–1,500/μL; moderate, 500 to <1,000/μL; and severe <500/μL.
Results A total of 423 patients were investigated. There were 156 (36.9%), 193 (45.6%), and 74 (17.5%) patients in the mild, moderate, and severe groups, respectively. Bacteremia was detected in one (0.02%) patient and SBI in 21 (4.9%) patients. No significant correlation was found between the incidence of SBI and bacterial infection rate among different age groups (p > 0.05). The incidence of SBI varied significantly according to the severity of the neutropenia (p = 0.012) and as the neutropenia became more severe, the incidence of SBI increased (p = 0.015).
Conclusion The clinical outcome of neutropenia in previously healthy and immunocompetent children is generally good with a relatively low incidence of SBI. We suggest that aggressive therapy and frequent follow-up should be reserved for previously healthy neutropenic children with SBI.
TBC1D24 and Its Related Epileptic Encephalopathy
Authors: Timpanaro Tiziana , La Mendola Flavia , Billone Sebastiano , Nora Alessandra Di , Collotta Ausilia , Sauna Alessandra , Salafia Stefania , Falsaperla Raffaele 
Published: May 2021

Abstract
TBC1D24, mapped to 16p13.3, encodes a protein containing a Tre2/Bub2/Cdc16 (TBC) domain, belonging to the super-family of Rab GTPase activating proteins (Rab-GAP). These proteins regulate various functions, including the regulation of the traffic of the vesicular membrane. Several TBC1D24 mutations have been related to autosomal recessive neurological disorders, including severe developmental encephalopathies with malignant early childhood epilepsy, benign epilepsy, epileptic encephalopathy, and a complex neurological syndrome characterized by deafness, onychodystrophy, bone and neurological degeneration. Mutations of TBC1D24 have also been reported in patients with nonsyndromic deafness with dominant or recessive inheritance. Mechanisms underlying TBC1D24-associated disorders and the functions of TBC1D24 products in the generation of such complex spectrum of diseases remain partly unclear and future studies are needed to clarify this aspect, in order to improve the management of seizures and for the prevention of complication (including death) of newly diagnosed patients affected by TBC1D24-related disorders.
KCNT1-Related Epilepsy: A Review
Authors: Venti Valeria , Ciccia Lina , Scalia Bruna , Sciuto Laura , Cimino Carla , Marino Simona , Praticò Andrea D. , Falsaperla Raffaele 
Published: May 2021

Abstract
KCNT1 gene encodes the sodium-dependent potassium channel reported as a causal factor for several different epileptic disorders. The gene has been also linked with cardiac disorders and in a family to sudden unexpected death in epilepsy. KCNT1 mutations, in most cases, result in a gain of function causing a neuronal hyperpolarization with loss of inhibition. Many early-onset epileptic encephalopathies related to gain of function of KCNT1 gene have been described, most often associated with two phenotypes: malignant migrating focal seizures of infancy and familial autosomal-dominant nocturnal frontal lobe epilepsy; however, there is no clear phenotype–genotype correlation, in fact same mutations have been represented in patients with West syndrome, Ohtahara syndrome, and early myoclonic encephalopathy. Additional neurologic features include intellectual disability, psychiatric disorders, hypotonia, microcephaly, strabismus, and movement disorders. Conventional anticonvulsant, vagal stimulation, and ketogenic diet have been used in the absence of clinical benefit in individuals with KCNT1-related epilepsy; in some patients, quinidine therapy off-label has been practiced successfully. This review aims to describe the characteristics of the gene, the phenotypes related to genetic mutations with the possible genotype–phenotype correlations and the treatments proposed to date, discussing the comorbidities reported in the literature.
Collective Capacity to Aspire? Aspirations and Livelihood Strategies in the Zambezi Region, Namibia
Authors: Aring Mascha , Reichardt Ole , Katjizeu Ewaldine Menjono , Luyanda Brendan , Hulke Carolin 
Published: May 2021

AbstractThis paper investigates rural development from a micro-level standpoint, focusing on individual and collective aspirations. We aim to deepen understanding of how a person’s socio-economic environment shapes their aspirations and simultaneously how aspirations contribute to future-oriented actions. In combining concepts of sustainable livelihoods and aspirations with a context of ‘ordinary uncertainties’ (Pine, Ordinary uncertainties: remembering the past and imagining the future at times of rupture and mobility. In: Paper presented at the conference “Rurality and Future-Making. Comparative Perspectives from Europe, the Middle East, and the Mediterranean”, 22–24 May, Cologne, Germany, 2019), we discuss the role of individual and collective aspirations in developing livelihood strategies. Drawing on qualitative data from field research in Namibia’s Zambezi region, we identify crucial factors that influence aspirations: multiple uncertainties, experiences, and role models. Access to diverse experiences and social exchange shapes future-oriented aspirations, and therefore needs to be included in rural development strategies that account for diversity within communities.
The social dilemmas of climate change and antibiotic resistance: an analytic comparison and discussion of policy implications
Authors: Harring Niklas , Krockow Eva M. 
Published: May 2021

AbstractClimate change and antimicrobial resistance are two of humanity’s most imminent problems. Reducing the use of fossil fuels and antibiotics is essential for managing the threats, and theory-based policies are required to stimulate urgently needed behaviour change. This article analyses climate change and antimicrobial resistance within the context of game theory. Previous literature has identified these problems as Commons tragedies, where inherent incentive structures encourage selfish overuse of existing resources. While the game theoretical models provide a helpful conceptual basis, the present analysis suggests discrepancies between some of the theoretical assumptions and the practical realities of climate change and antimicrobial resistance. These include complex networks of decision makers, non-binary choice contexts complicated by temporal and spatial distance between choices and outcomes, and different ethical implications of resource overuse. Policy implications are discussed, highlighting the need of global agreements for coordinating local initiatives for both dilemmas. However, different target groups may be necessary to address the existence of gate keepers (e.g., medical prescribers) in antibiotic use. Additionally, while certain policies types (e.g., information policies) apply to both dilemmas, more nuanced ethical considerations mean that some economic policies (e.g., punitive policies) may be limited to managing climate change.
Compact broadband Compton spectroscopy used for intense laser-driven gamma rays
Authors: Yang Tao , Hu Guang-yue , Li Meng-ting , Lian Chang-wang , Zhang Zhen-chi , Luo Wen , Ma Yue , Zheng Jian 
Published: May 2021

A compact broadband Compton spectrometer is designed to measure the continuous spectrum of gamma-ray sources driven by an intense laser. The incident gamma rays are converted into electrons in low-Z materials by Compton scattering. Produced by a pair of stepped magnets, a weaker-front–stronger-rear nonuniform magnetic field in the electron magnetic spectrometer is used to spectrally resolve the scattered electrons, leading to a broadband gamma-ray spectral coverage of 2–20 MeV in a compact volume. Flat imaging-plate detectors are placed near the focused imaging points of the magnetic spectrometer to record the dispersed electrons, thereby achieving an optimal spectral resolution of 6%–13% in the energy range of 3–20 MeV. The spectrometer is used successfully to measure the gamma-ray spectrum generated by the high-energy electron beams produced by a femtosecond-laser-driven wakefield.
A resonance suppression method in platform style inertial reference unit via particle swarm optimization notch filter
Authors: Zhou Z. , Li X. F. , Tuo W. X. , Zheng A. Q. 
Published: May 2021

With the development of laser communication, remote sensing imaging, and other technologies, an inertial reference unit (IRU) plays an essential part in the line-of-sight (LOS) stabilization system used for acquiring, pointing, and tracking targets. The IRU provides a stable reference beam to realize accurate LOS pointing under external disturbances. Compared with the frame style IRU, the platform style IRU (PIRU) can achieve a higher bandwidth and better precision. However, mechanical resonance is introduced by a flexure hinge inevitably in the PIRU, which affects the performance of the LOS stabilization system. In this paper, an open-loop dynamic model of PIRU is established. Identification experiments are carried out with results indicating a 28.7 dB resonance peak at 27.07 Hz in the x axis and a 30.3 dB resonance peak at 26.59 Hz in the y axis. An asymmetric notch filter is used to suppress the resonance peak to achieve a higher control bandwidth. A fitness function is designed to represent the effect of resonance suppression. A particle swarm optimization algorithm is used to search for an optimal solution of the fitness function to obtain the parameters of the asymmetric notch filter. Experimental results show that the resonance peak is reduced by 97.88% and the system bandwidth reaches 159.31 Hz.
Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities
Authors: Yin Qian , Yu Wong , Grzeskowiak Caitlin L. , Li Jing , Huang Huang , Guo Jing , Chen Liang , Wang Feng , Zhao Fan , von Boehmer Lotta , Metzner Thomas J. , Leppert John T. , Chien Yueh-hsiu , Kuo Calvin J. , Davis Mark M. 
Published: May 2021

SignificanceTumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens but are generally inactive. Self-specific CD8+T cells are particular characteristics of tumor types with lower tumor mutation burden and poorer outcomes. Unlike foreign-specific T cells, they have been curiously resistant to stimulation with cognate antigens. We developed an innate immunity-stimulating nanoparticle to activate tumor-infiltrating CD8+T cells recognizing both self- and neoantigens in a potent yet safe manner. This resulted in effective tumor growth inhibition or elimination in two murine tumor models and the activation of endogenous T cells in patient-derived tumor organoids across three cancer types. This strategy represents a promising pathway for broadly effective cancer immunotherapy.
Dynamic population stage structure due to juvenile–adult asymmetry stabilizes complex ecological communities
Authors: de Roos André M. 
Published: May 2021

SignificanceUsing food web models that account for juvenile and adult individuals of species, I show that commonly observed differences between juveniles and adults in foraging capacity and predation risk result in larger, more complex communities than predicted by models without stage structure. Based on their species interaction networks these complex and diverse communities would be expected to be unstable, but these destabilizing effects of species interactions are overruled by stabilizing changes in juvenile–adult stage structure. Differences between juvenile and adult individuals hence offer a natural resolution to the diversity–stability enigma of ecological communities.