bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasmapheresis: a feasible choice for bullous pemphigoid patients infected with SARS‐CoV‐2
Authors: Cui Yu , Hu Caixia , Cheng Yi , Han Xiaomei , Wang Wenqing 
Published: September 2021

AbstractBullous pemphigoid (BP) patients were vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection because they have similar risk factors, so we should pay attention to patients with BP during the epidemic of coronavirus disease‐19 (COVID‐19). As far as treatment is concerned, many strategies for BP were changed during the epidemic. Plasmapheresis not only has been included in the guidelines for BP but also has been used successfully to rescue COVID‐19 patients, especially in severe cases. Therefore, it is a feasible choice for BP patients, especially for refractory BP patients, infected with SARS‐CoV‐2. Apart from these, we have reviewed some points for attention during the plasmapheresis session.
Comparative study of physicochemical properties of dextran and reuteran synthesised by two glucansucrases that are highly similar in amino acid sequence
Authors: Chen Ziwei , Ni Dawei , Cheng Mei , Zhu Yingying , Mu Wanmeng 
Published: September 2021

AbstractRecently, lactic acid bacteria (LAB)‐derived α‐glucans have drawn strong attention owing to their various structural organisation and wide (potential) applications in the medicine, food, cosmetic, and biotechnology industries. However, the physicochemical properties of diverse α‐glucans, particularly reuteran, remain largely unknown, which significantly impedes their wider applications. This study comparatively evaluated the physicochemical properties of two different α‐glucans, Gtf‐DSM dextran, and GtfO reuteran produced by the dextransucrase Gtf‐DSM from Lactobacillus ingluviei DSM 14792 and the reuteransucrase GtfO from Lactobacillus reuteri ATCC 55730, which are two glucansucrases highly similar in amino acid sequence. The surface morphology analysis demonstrated that Gtf‐DSM dextran had a holey and fissured microstructure; however, GtfO reuteran had an irregular dendritic microstructure, forming a fibrous network. Compared to GtfO reuteran, Gtf‐DSM dextran showed a larger average particle diameter (162.4 versus 90.3 nm). Additionally, Gtf‐DSM dextran displayed some prominent properties, such as better thermostability, higher apparent viscosity, and stronger gel‐forming capability, than GtfO reuteran. These results provide a theoretical basis for stimulating the applications of LAB‐derived α‐glucans in various fields.
Comorbidity‐adjusted NEWS predicts mortality in suspected patients with COVID‐19 from nursing homes: Multicentre retrospective cohort study
Authors: Martín‐Rodríguez Francisco , Sanz‐García Ancor , Melero Guijarro Laura , Ortega Guillermo J. , Gómez‐Escolar Pérez Marta , Castro Villamor Miguel A. , Santos Pastor Julio C. , Delgado Benito Juan F. , López‐Izquierdo Raúl 
Published: September 2021

AbstractAimsTo assess the prognostic accuracy of comorbidity‐adjusted National Early Warning Score in suspected Coronavirus disease 2019 patients transferred from nursing homes by the Emergency Department.DesignMulticentre retrospective cohort study.MethodsPatients transferred by high‐priority ambulances from nursing homes to Emergency Departments with suspected severe acute respiratory syndrome coronavirus 2 infection, from March 12 to July 31 2020, were considered. Included variables were: clinical covariates (respiratory rate, oxygen saturation, systolic blood pressure, heart rate, temperature, level of consciousness and supplemental oxygen use), the presence of comorbidities and confirmatory analytical diagnosis of severe acute respiratory syndrome coronavirus 2 infection. The primary outcome was a 2‐day mortality rate. The discriminatory capability of the National Early Warning Score was assessed by the area under the receiver operating characteristic curve in two different cohorts, the validation and the revalidation, which were randomly selected from the main cohort.ResultsA total of 337 nursing homes, 10 advanced life support units, 51 basic life support units and 8 hospitals in Spain entailing 1,324 patients (median age 87 years) was involved in this study. Two‐day mortality was 11.5% (152 cases), with a positivity rate of severe acute respiratory syndrome coronavirus 2 of 51.2%, 77.7% of hospitalization from whom 1% was of intensive care unit admission. The National Early Warning Score results for the revalidation cohort presented an AUC of 0.771, and of 0.885, 0.778 and 0.730 for the low‐, medium‐ and high‐level groups of comorbidities.ConclusionThe comorbidity‐adjusted National Early Warning Score provides a good short‐term prognostic criterion, information that can help in the decision‐making process to guide the best strategy for each older adult, under the current pandemic.Impact

What problem did the study address?

Under the current coronavirus disease 2019 pandemic, targeting older adults at high risk of deterioration in nursing homes remains challenging.

What were the main findings?
Comorbidity‐adjusted National Early Warning Score helps to forecast the risk of clinical deterioration more accurately.

Where and on whom will the research have impact?
A high NEWS, with a low level of comorbidity is associated with optimal predictive performance, making these older adults likely to benefit from continued follow up and potentially hospital referral under the current coronavirus disease 2019 pandemic.
Incursions of sea lamprey, Petromyzon marinus, and striped bass, Morone saxatilis, in Labrador waters: Episodic events or evidence of a northward range expansion?
Authors: Van Leeuwen Travis E. , Cote David , Pretty Christina , Townley Joseph , Poole Rebecca , Dempson Brian , Bird Tomas J. , Kippenhuck Charlene , Morris Corey 
Published: September 2021

AbstractWe describe observations of sea lamprey (Petromyzon marinus) and striped bass (Morone saxatilis) incursions into Labrador, Canada. While P. marinus have been periodically observed in similar latitudes, their numbers have conspicuously increased in estuarine environments in 2020. In contrast, M. saxatilis were not observed from Labrador until 2017 but appear to be declining after the initial surge in abundance that peaked in 2018. It remains unclear whether spawning populations of either species exist. Given the potential to negatively affect species of commercial and cultural importance through predation, follow‐up surveys are warranted.
Specific immunity proteomic profile of the skin mucus of Antarctic fish Chionodraco hamatus and Notothenia coriiceps
Authors: Huang Shaojun , Jia Ruonan , Hu Ruiqin , Zhai Wanying , Jiang Shouwen , Li Wenhao , Wang Faxiang , Xu Qianghua 
Published: September 2021

AbstractThe white‐blooded Antarctic icefish is the only known vertebrate lacking oxygen‐transporting haemoglobins. Fish skin mucus, as the first line of defence against pathogens, can reflect fish welfare. In this study, we analysed the skin mucus proteome profiles of the two Antarctic fish species, the white‐blooded Antarctic icefish, Chionodraco hamatus, and the red‐blooded Antarctic fish, Notothenia coriiceps, unfolding the different proteins by liquid chromatography coupled with tandem mass spectrometry isobaric tags for relative and absolute quantitation (iTRAQ) technology. Of the 4444 totally identified proteins, 227 differentially expressed proteins (DEPs) were found in the comparison between C. hamatus and N. coriiceps, of which 121 were upregulated and 106 were downregulated in the icefish. In the Kyoto Encyclopedia of Genes and Genomes pathway annotation, we found two pathways “Legionellosis” and “Complement and coagulation cascades” were significantly enriched, among of which innate immune candidate proteins such as C3, CASP1, ASC, F3 and C9 were significantly upregulated, suggesting their important roles in C. hamatus immune system. Additionally, the DEP protein–protein interaction network analysis and “Response to stress” GO category provided candidate biomarkers for deep understanding of the distinct immune response of the two Antarctic fish underlying the cold adaptation.
Rates of skincare product and cosmetic procedure use in patients with acne vulgaris and the effective factors: A multicenter study with 1,755 patients
Authors: Aslan Kayıran Melek , Karadağ Ayşe Serap , Alyamaç Gökçen , Çevirgen Cemil Bengü , Demirseren Düriye Deniz , Taş Demircan Yuhanize , Aksoy Hasan , Kılıç Sevilay , Kara Polat Asude , İnan Yüksel Esma , Kalkan Göknur , Elibüyük Aksaç Sema , Kutlu Ömer , Altıntaş Kakşi Sümeyye , Şikar Aktürk Aysun , Özkök Akbulut Tuğba , Sarıkaya Solak Sezgi , Oğuz Topal İlteriş , Yazıcı Serkan , Kaya Özden Hatice , Koska Mahmut Can , Uzunçakmak Tuğba Kevser , Ataseven Arzu , Işık Begüm , Alpsoy Erkan 
Published: September 2021

AbstractBackgroundSkincare products and cosmetic procedures are used as an adjunct or complementary to conventional drug therapy for acne vulgaris (AV).ObjectiveTo evaluate the use of skincare products and the frequency of cosmetic procedures in AV treatment.MethodsA total of 1,755 patients with AV completed the survey prepared by the researchers and the Cardiff Acne Disability Index (CADI) questionnaire. The clinical findings and the Food and Drug Administration (FDA) severity scores were recorded by the dermatologists.ResultsFor AV, 66.7% of the patients stated that they used skincare products and 26.7% had undergone cosmetic procedures. The use of skincare products was statistically significantly higher in women (female: 74.5%, male: 57.7%, p < 0.0001); older people (users: 22 ± 7.6years, non‐users: 21.2 ± 5.7 years, p < 0.0001); patients with a higher CADI score (users: 7 ± 3.7, non‐users: 6.9 ± 4.3, p = 0.010); FDA severity score 2 and 3 (FDA‐1: 58.1%; FDA‐2: 72.4%, FDA‐3: 73%, FDA‐4: 67%, p < 0.0001); long‐term disease (users: 57 ± 43 months; non‐users: 47.7 ± 42.3 months, p < 0.0001); facial involvement (present: 70.2%, absent: 51.4%, p = 0.017); high income levels (users: 73.5%; non‐users: 26.5%, p = 0.001); and graduate or post‐graduate degrees (undergraduate≤%62.8, graduate≥%76.8, p < 0.0001). The rate of cosmetic procedures was higher in those with higher CADI scores (users: 7.8 ± 3.8; non‐users: 7.1 ± 3.96, p < 0.0001); older patients (users: 22.7 ± 10.7 years; non‐users: 21.3 ± 5 years, p < 0.0001); high school (25.6%); and graduate (28.9%) education (p = 0.043), those with lower disease severity (FDA‐1: 31.1%; FDA‐2: 28.5%, FDA‐3: 27.1%, FDA‐4: 20.4%, p = 0.022); smokers (smokers: 32.5%; non‐smokers: 25.5%, p = 0.020), and those with AV in the family (present: 29.8%; absent: 24.2%, p = 0.009). The patients most frequently used cleansers (85.2%) as cosmetic products, and most commonly underwent skincare treatment (71%) as an interventional procedure. They mostly learned about such products and methods from the Internet, and 33.3% of the participants had undergone procedures performed by non‐physicians.ConclusionThe patients generally choose skincare products as a result of their Internet search and sometimes have these procedures performed by non‐physicians. Dermatologists should be aware of this situation and inform their patients about appropriate products and procedures.
Bibliometric analysis of the effects of ginseng on skin
Authors: Meng Hong , Liu Xin‐Ke , Li Jia‐Rui , Bao Tu‐ya , Yi Fan 
Published: September 2021

AbstractObjectiveGinseng is widely used in cosmetics and skin care. The progress of research on the effect of ginseng on the skin was explored through a summary and analysis of skin‐related studies on ginseng conducted over in the past 20 years, and this exploration aimed to elucidate new research opportunities with regard to the development and application of ginseng treatments for the skin.Materials and methodsKeywords were used to retrieve human studies related to the use of ginseng to treat skin conditions from the Web of Science. Scientometric analyses were performed in R to analyze the studies on the human skin‐related effects of ginseng conducted from 2000 to 2019.ResultsThe main active ingredient in ginseng is ginsenoside, and its effects on the skin are mostly anti‐aging and whitening. Ginseng extract regulates the levels of matrix metalloproteinases in human fibroblast type I collagen to improve the elasticity and water content of skin. In addition, ginseng inhibits the transcription factors or signaling pathways involved in the formation of melanin, it exerts a whitening effect. The authors of the retrieved studies are mostly located in Asia, mainly South Korea and China. Wang Y, Kim JH, and Kim YJ are relatively influential scholars, these ginseng‐related articles published in the Journal of Ginseng Research, Molecules and other journals are very important in this field.ConclusionThis study shows the development of trends in research on ginseng as a raw cosmetic material used on the skin and thus enables researchers to rapidly understand the key information in the field of ginseng research, comprehend the research directions, and improve their research efficiency.
Currency Mispricing and Dealer Balance Sheets
Authors: CENEDESE GINO , DELLA CORTE PASQUALE , WANG TIANYU 
Published: September 2021

ABSTRACTWe find dealer‐level evidence that recent regulation on the leverage ratio requirement causes deviations from covered interest parity. Our analysis uses a unique data set of currency derivatives with disclosed counterparty identities together with exogenous variation introduced by the U.K. leverage ratio framework. Dealers who are affected by the regulatory shock charge an additional premium of about 20 basis points per annum for synthetic dollar funding relative to unaffected dealers. This finding holds even after controlling for changes in clients' demand. Also, some clients increase their trading activity with unaffected dealers with whom they already had a preexisting relationship.
Inequality Aversion, Populism, and the Backlash against Globalization
Authors: PÁSTOR ĽUBOŠ , VERONESI PIETRO 
Published: September 2021

ABSTRACTMotivated by the recent rise of populism in Western democracies, we develop a tractable equilibrium model in which a populist backlash emerges endogenously in a strong economy. In the model, voters dislike inequality, especially the high consumption of “elites.” Economic growth exacerbates inequality due to heterogeneity in preferences , which leads to heterogeneity in returns on capital. In response to rising inequality, voters optimally elect a populist promising to end globalization. Equality is a luxury good. Countries with more inequality, higher financial development, and trade deficits are more vulnerable to populism, both in the model and in the data.
Assessment of hepatic involvement by two‐dimensional shear wave elastography in paediatric patients with cystic fibrosis
Authors: Yavuz Sibel , Pişkin Ferhat C , Oktay Cemil , Tümgör Gökhan 
Published: September 2021

AimThis study aimed to investigate parenchymal changes in the liver in paediatric patients with cystic fibrosis (CF) and to analyse diagnostic performance of two‐dimensional shear wave elastography (2D‐SWE) for the detection of hepatic involvement.MethodsPatients with CF treated and followed at our centre were evaluated prospectively. All patients underwent liver tissue stiffness (TS) measurements by 2D‐SWE, in addition to routine clinical assessments, laboratory work‐up and abdominal ultrasound imaging. Data from patients with CF were compared with healthy control subjects.ResultsThis study included 39 patients with CF and 37 healthy controls. Patients had a mean body weight of 29.9 (16.6–55) kg, mean age of 9 (5–17) years, mean height of 130 (107–172) cm and a mean body mass index of 16.1 (12.8–21.4) kg/m2. Average SWE values of the liver were 1.02 (0.70–1.60) m/s in patients with CF (n = 39) and 0.89 (0.60–1.35) m/s in healthy controls (n = 37). Cystic fibrosis patients had significantly increased tissue stifness by liver elastography compared to controls (P = 0.005).ConclusionParenchymal liver changes may occur early in cystic fibrosis, which cannot be detected by conventional ultrasonography but may be demonstrated by 2D‐SWE. Based on this cross‐sectional study, 2D‐SWE may be a promising, simple and non‐invasive modality for objective monitoring of patients with cystic fibrosis who require lifelong follow‐up, by providing numerical data for tissue stiffness early in the disease.
Effects of malic or citric acid on the fermentation quality, proteolysis and lipolysis of alfalfa silage ensiled at two dry matter contents
Authors: Ke Wencan , Ding Zitong , Li Fuhou , Xu Dongmei , Bai Jie , Muhammad Ishaq , Zhang Yixin , Zhao Liansheng , Guo Xusheng 
Published: September 2021

AbstractThis study evaluated the effects of two organic acids on the fermentation of alfalfa silages at different dry matter (DM) contents. Alfalfa was wilted to DM contents of 30% (moderately low) and 38% (normal) and ensiled without additives (control) or treated with 0.6% fresh matter DL‐malic acid (MA) or 0.6% fresh matter citric acid (CA) for 60 days. After ensiling, silages with a normal DM were higher in pH, water‐soluble carbohydrates (WSC) and DM loss (p < 0.05) when compared to silages ensiled at a moderately low DM. The higher DM content also limited proteolysis in silages indicated by lower concentrations of ammonia N (NH3‐N). Compared with the control group, MA and CA‐treated silages had lower pH, lower concentrations of acetic acid and NH3‐N but higher concentrations of lactic acid. The addition of MA and CA reduced DM losses in silages when compared to the control group except for MA‐treated silage at a moderately low DM in which only numerically lower DM loss was observed. Malic acid and CA also resulted in a higher proportion of polyunsaturated fatty acids, especially in silages with a moderately low DM. Including MA and CA could promote silage fermentation, limit proteolysis and lipolysis at the lower and medium‐to‐high end of DM contents in alfalfa silages.
Ventral acetabular augmentation for management of caudoventral luxation following total hip replacement in dogs
Authors: Chantziaras V. , Pink J. , Kulendra E. , Easter T. G. , Bilmont A. , Gemmill T. J. 
Published: September 2021

ObjectiveTo report ventral acetabular augmentation with an internal fixator for management of caudoventral luxation following total hip replacement in dogs and to report clinical outcomes.Materials and MethodsClinical records from three UK‐based referral hospitals were reviewed retrospectively between 2010 and 2020 to identify dogs with caudoventral hip luxation managed by ventral acetabular augmentation. Hip prosthesis component orientation was radiographically assessed to identify potential risk factors associated with the luxation. Clinical and radiographic assessments were performed at short‐term (≤12 weeks) and long‐term (>12 months) follow‐up and all complications were recorded. A standardised owner telephone questionnaire was used to assess long‐term outcomes when a clinical assessment was unavailable.ResultsNine dogs were included. Risk factors contributing to the luxation could not be defined. Implants used included a string‐of‐pearls plate (6/9), a polyaxial locking plate combined with a polyethylene implant (1/9) or a polyethylene implant alone (2/9). Complications occurred in two of nine dogs, including recurrent luxation and femoral stem loosening; both dogs had received a polyethylene implant alone, of which one received explantation of the hip prosthesis. Median long‐term follow‐up was 39 months (range 13.5–62). Seven dogs who received a ventral acetabular plate achieved full function of the operated limb and the overall outcome was good for eight dogs. Follow‐up radiographs revealed stable hip prostheses in dogs who received a ventral plate, with the longest assessment at 37 months postoperatively. Owner satisfaction was good for all cases.Clinical SignificanceVentral acetabular augmentation can successfully manage caudoventral luxation following total hip replacement in dogs.
Late presentation for HCV care: Time to target people with diabetes and/or hazardous alcohol use (ANRS CO22 HEPATHER cohort)
Authors: Santos Melina , Protopopescu Camelia , Delarocque‐Astagneau Elizabeth , Bourlière Marc , Petrov‐Sanchez Ventizlava , Di Beo Vincent , Larrey Dominique , Baudoin Maël , Dorival Céline , Bureau Morgane , Fontaine Hélène , Carrat Fabrice , Marcellin Fabienne , Pol Stanislas , Carrieri Patrizia ,   the ANRS CO22 HEPATHER study group
Published: September 2021

AbstractBackground and AimsLate presentation for care of hepatitis C virus (HCV) infection – defined as having severe liver fibrosis when first consulting a specialist for HCV care – increases morbidity and mortality. Identifying the socio‐behavioural correlates of late presentation is essential to improve HCV strategies to optimize HCV cascade of care. We investigated clinical and socio‐behavioural correlates of late presentation for care in HCV mono‐infected individuals.MethodsThis study included chronic HCV mono‐infected patients participating in the French national cohort ANRS CO22 HEPATHER, starting in 2012. The correlates of late presentation were estimated using a Heckman probit selection model, which takes into account the possible selection bias because of missing data in the outcome.ResultsAmong the 9174 study patients, 1236 had available data on liver fibrosis stage at first presentation for HCV care. Of these, 591 (47.8%) were late presenters. In a multivariable analysis adjusted for age, sex and HCV genotype, having diabetes (adjusted coefficient [95% confidence interval]: 0.55 [0.30; 0.80]), current hazardous alcohol use (0.36 [0.03; 0.69]) and current abstinence but past hazardous alcohol use (0.42 [0.19; 0.64]) (vs. current abstinence and no past hazardous use) were all independently associated with late presentation for HCV care.ConclusionsAs late presentation severely affects HCV cascade of care, our findings bring important new evidence about the need to promptly identify and target people with diabetes and/or past or current hazardous alcohol use for HCV screening and treatment within the wider context of the WHO goal to eliminate HCV by 2030.