bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymer-dendrimer Hybrids as Carriers of Anticancer Agents
Authors: Rodríguez-Acosta Guillermo Leobardo , Hernández-Montalbán Carlos , Vega-Razo María Fernanda Sabrina , Castillo-Rodríguez Irving Osiel , Martínez-García Marcos 
Published: September 2021

:
In recent years, polymeric materials with the ability to self-assemble into micelles have
been increasingly investigated for application in various fields, mainly in biomedicine. Micellar
morphology is important and interesting in the field of drug transport and delivery since micelles
can encapsulate hydrophobic molecules in their nucleus, improve the solubility of drugs, have active
molecules in their outer layer, and, due to their nanometric size, they can take advantage of the
EPR effect, prolong circulation time and avoid renal clearance. Furthermore, bioactive molecules
(could be joined covalently or by host-host interaction), such as drugs, bioimaging molecules, proteins,
targeting ligands, “cross-linkable” molecules, or linkages sensitive to internal or external stimuli,
can be incorporated into them. The confined multivalent cooperativity and the ability to modify
the dendritic structure provide versatility to create and improve the amphiphiles used in the micellar
supramolecular field. As discussed in this review, the most studied structures are hybrid copolymers,
which are formed by the combination of linear polymers and dendrons. Amphiphilic dendrimer
micelles have achieved efficient and promising results in both in vitro and in vivo tests, and
this encourages research for their future application in nanotherapies.
Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer’s Disease
Authors: Zhou Rui , Chen Li-li , Yang Hai , Li Ling , Liu Juan , Chen Le , Hong Wen-Juan , Wang Cong-guo , Ma Jing-Jing , Huang Jie , Zhou Xin-Fu , Liu Dong , Zhou Hua-Dong 
Published: September 2021

Background:
High cholesterol aggravates the risk development of Alzheimer's disease
(AD). AD is closely related to the transport impairment of Amyloid-β (Aβ) in the blood-brain barrier.
It is unclear whether high cholesterol affects the risk of cognitive impairment in AD by affecting Aβ
transport. The purpose of the study is to investigate whether high cholesterol regulates Aβ transport
through low-density Lipoprotein Receptor-Related Protein 1 (LRP1) and Receptor for Advanced Glycation
End products (RAGE) in the risk development of AD.

Methods:
We established high cholesterol AD mice model. The learning and memory functions were
evaluated by Morris Water Maze (MWM). Cerebral microvascular endothelial cells were isolated,
cultured, and observed. The expression levels of LRP1 and RAGE of endothelial cells and their effect
on Aβ transport in vivo were observed. The expression level of LRP1 and RAGE was detected in cultured
microvessels after using Wnt inhibitor DKK-1 and β-catenin inhibitor XAV-939.

Results:
Hypercholesterolemia exacerbated spatial learning and memory impairment. Hypercholesterolemia
increased serum Aβ40 level, while serum Aβ42 level did not change significantly. Hypercholesterolemia
decreased LRP1 expression and increased RAGE expression in cerebral microvascular
endothelial cells. Hypercholesterolemia increased brain apoptosis in AD mice. In in vitro experiment,
high cholesterol decreased LRP1 expression and increased RAGE expression, increased Aβ40 expression
in cerebral microvascular endothelial cells. High cholesterol regulated the expressions of LRP1
and RAGE and transcriptional activity of LRP1 and RAGE promoters by the Wnt/β-catenin signaling
pathway.

Conclusion :
High cholesterol decreased LRP1 expression and increased RAGE expression in cerebral
microvascular endothelial cells, which led to Aβ transport disorder in the blood-brain barrier. Increased
Aβ deposition in the brain aggravated apoptosis in the brain, resulting to cognitive impairment of AD
mice.
Recombinant Human Regenerating Gene 4 Attenuates the Severity of
Osteoarthritis by Promoting the Proliferation of Articular Chondrocyte
in an Animal Model
Authors: Zhang Dong , Liang Cheng-Wei , Li Xue-jia , Zhu Fei , Li Bo 
Published: September 2021

Introduction:
Osteoarthritis (OA) is a dominant cause of morbidity and disability. As a
chronic disease, its etiological risk factors and most therapies at present, are empirical and symptomatic.
Regenerating gene 4 (Reg4) is involved in cell growth, survival, regeneration, adhesion, and
resistance to apoptosis, which are partially thought to be the pathogenic mechanisms of OA. However,
the proper role of Reg4 in OA is still unknown.

Methods:
In this study, a consecutive administration of rhReg4 was applied to normal Sprague-
Dawley rats or rats after OA induction. Histological changes and chondrocyte proliferation in the
articular cartilage were measured.

Results:
We found that RhReg4 promotes chondrocyte proliferation in normal rats, and RhReg4 attenuated
the severity of OA in rats by promoting chondrocytes’ proliferation in OA rats.

Conclusion:
In conclusion, recombinant human regenerating gene 4 (rhReg4) attenuates the severity
of osteoarthritis in OA animal models and may be used as a new method for the treatment of osteoarthritis.
Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour
Map Analysis and COVID-19 Therapeutics
Authors: Selvaraj Chandrabose , Dinesh Dhurvas Chandrasekaran , Krafcikova Petra , Boura Evzen , Aarthy Murali , Pravin Muthuraja Arun , Singh Sanjeev Kumar 
Published: September 2021

:
The pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-
2), is responsible for multiple worldwide lockdowns, an economic crisis, and a substantial increase
in hospitalizations for viral pneumonia along with respiratory failure and multiorgan dysfunctions.
Recently, the first few vaccines were approved by World Health Organization (WHO)
and can eventually save millions of lives. Even though, few drugs are used in emergency like
Remdesivir and several other repurposed drugs, still there is no approved drug for COVID-19. The
coronaviral encoded proteins involved in host-cell entry, replication, and host-cell invading mechanism
are potential therapeutic targets. This perspective review provides the molecular overview of
SARS-CoV-2 life cycle for summarizing potential drug targets, structural insights, active site contour
map analyses of those selected SARS-CoV-2 protein targets for drug discovery, immunology,
and pathogenesis.
Radioprotective Effect of Febuxostat Against Testicular Damage Induced
by Ionizing Radiation in Mice
Authors: Hosseinimehr Seyed Jalal , Amiri Fereshteh Talebpour , Raeispour Marziyeh , Farzipour Soghra 
Published: September 2021

Background:
The testis is one of the most radiosensitive tissues in pelvic radiotherapy,
especially in prostate cancer. Febuxostat (FBX), as an inhibitor of xanthine oxidase, has anti-inflammatory,
antioxidant, and anti-apoptosis properties.

Objectives:
The aim of this research was to survey the protective effect of FBX against irradiation
(IR)-induced testis damage via the attenuation of oxidative stress.

Methods:
Male adult mice were randomly assigned into eight groups: control, FBX with three doses
of 5, 10, and 15 mg/kg, IR with 6 Gy, IR + FBX (IR + FBX in three doses), respectively. In the
IR + FBX groups, FBX was administrated for 8 consecutive days, and then mice were exposed to
IR at a dose of 6 Gy on the 9th day. One day after irradiation, biochemical parameters were evaluated
in the testis of animals, while histopathological assessment had been performed on 14th day.

Results:
Irradiation led to the induction of testicular toxicity. FBX significantly protected histopathological
alterations and decreased oxidative stress parameters in irradiated testis. Besides, FBX
increased the diameter and germinal epithelial thickness of seminiferous tubules and Johnson’s
score in irradiated mice.

Conclusion:
Data showed that FBX markedly protected testicular injury induced by IR by inhibiting
oxidative stress and may be considered as an infertility inhibitor in cancer patients, especially
prostate cancer.
Psychological Impact of the COVID-19 Pandemic and Social Determinants on the Portuguese Population: Protocol for a Web-Based Cross-sectional Study
Authors: Aguiar A , Pinto M , Duarte R 
Published: September 2021

BackgroundThe COVID-19 outbreak and consequent physical distance measures implemented worldwide have caused significant stress, anxiety, and mental health implications among the general population. Unemployment, working from home, and day-to-day changes may lead to a greater risk of poor mental health outcomes.ObjectiveThis paper describes the protocol for a web-based cross-sectional study that aims to address the impact of the COVID-19 pandemic on mental health.MethodsIndividuals from the general population aged 18 years or more and living in Portugal were included in this study. Data collection took place between November 10, 2020, and February 10, 2021. An exponential, nondiscriminative, snowball sampling method was applied to recruit participants. A web-based survey was developed and shared on social media platforms (eg, Facebook, Instagram, Twitter, LinkedIn, and WhatsApp groups) and through e-mail lists for recruitment of the seeds.ResultsData analysis will be performed in accordance with the different variables and outcomes of interest by using quantitative methods, qualitative methods, or mixed methods, as applicable. A total of 929 individuals had completed the web-based survey during the 3-month period; thus, our final sample comprised 929 participants. Results of the survey will be disseminated in national and international scientific journals in 2021-2022.ConclusionsWe believe that the findings of this study will have broad implications for understanding the psychological impact of the COVID-19 pandemic on Portuguese residents, as well as aspects related to the informal economy. We also hope that the findings of this study are able to provide insights and guidelines for the Portuguese government to implement action. Finally, we expect this protocol to provide a roadmap for other countries and researchers that would like to implement a similar questionnaire considering the related conclusions.International Registered Report Identifier (IRRID)DERR1-10.2196/28071
Seroepidemiological Survey on the Impact of Smoking on SARS-CoV-2 Infection and COVID-19 Outcomes: Protocol for the Troina Study
Authors: Polosa Riccardo , Tomaselli Venera , Ferrara Pietro , Romeo Alba Corina , Rust Sonja , Saitta Daniela , Caraci Filippo , Romano Corrado , Thangaraju Murugesan , Zuccarello Pietro , Rose Jed , Cantone Giulio Giacomo , Ferrante Margherita , Belsey Jonathan , Cibella Fabio , Interlandi Elisa , Ferri Raffaele 
Published: September 2021

Background
After the global spread of SARS-CoV-2, research has highlighted several aspects of the pandemic, focusing on clinical features and risk factors associated with infection and disease severity. However, emerging results on the role of smoking in SARS-CoV-2 infection susceptibility or COVID-19 outcomes are conflicting, and their robustness remains uncertain.

Objective
In this context, this study aims at quantifying the proportion of SARS-CoV-2 antibody seroprevalence, studying the changes in antibody levels over time, and analyzing the association between the biochemically verified smoking status and SARS-CoV-2 infection.

Methods
The research design involves a 6-month prospective cohort study with a serial sampling of the same individuals. Each participant will be surveyed about their demographics and COVID-19–related information, and blood sampling will be collected upon recruitment and at specified follow-up time points (ie, after 8 and 24 weeks). Blood samples will be screened for the presence of SARS-CoV-2–specific antibodies and serum cotinine, being the latter of the principal metabolite of nicotine, which will be used to assess participants’ smoking status.

Results
The study is ongoing. It aims to find a higher antibody prevalence in individuals at high risk for viral exposure (ie, health care personnel) and to refine current estimates on the association between smoking status and SARS-CoV-2/COVID-19.

Conclusions
The added value of this research is that the current smoking status of the population to be studied will be biochemically verified to avoid the bias associated with self-reported smoking status. As such, the results from this survey may provide an actionable metric to study the role of smoking in SARS-CoV-2 infection and COVID-19 outcomes, and therefore to implement the most appropriate public health measures to control the pandemic. Results may also serve as a reference for future clinical research, and the methodology could be exploited in public health sectors and policies.

International Registered Report Identifier (IRRID)
DERR1-10.2196/32285
“El acto de leer en el mundo moderno”. De eruditione americana. Prácticas de lectura en los ámbitos académicos novohispanos
Authors: Bárcenas García Felipe 
Published: September 2021

Reseña de: De eruditione americana. Prácticas de lectura en los ámbitos académicos novohispanos. Manuel Suárez Rivera, coord. México. Universidad Nacional Autónoma de México, Instituto de Investigaciones Bibliográficas, 2019, 268 pp. ISBN: 978-607-30-2350-4.
Robust and Repeatable Biofabrication of Bacteria-Mediated Drug Delivery Systems: Effect of Conjugation Chemistry, Assembly Process Parameters, and Nanoparticle Size
Authors: Zhan Ying , Fergusson Austin , McNally Lacey R. , Davis Richey M. , Behkam Bahareh 
Published: September 2021

Bacteria-mediated drug delivery systems comprising nanotherapeutics
conjugated onto bacteria synergistically augment the efficacy of both
therapeutic modalities in cancer therapy. Nanocarriers preserve
therapeutics’ bioavailability and reduce systemic toxicity, while
bacteria selectively colonize the cancerous tissue, impart intrinsic and
immune-mediated antitumor effects, and propel nanotherapeutics
interstitially. The optimal bacteria-nanoparticle (NP) conjugates would
carry the maximal NP load with minimal motility speed hindrance for
effective interstitial distribution. Furthermore, a well-defined and
repeatable NP attachment density distribution is crucial to determining
these biohybrid systems’ efficacious dosage and robust performance.
Herein, we utilized our Nanoscale Bacteria-Enabled Autonomous Delivery
System (NanoBEADS) platform to investigate the effects of assembly
process parameters of mixing method, volume, and duration on NP
attachment density and repeatability. We also evaluated the effect of
linkage chemistry and NP size on NP attachment density, viability,
growth rate, and motility of NanoBEADS. We show that the linkage
chemistry impacts NP attachment density while the self-assembly process
parameters affect the repeatability and, to a lesser extent, attachment
density. Lastly, the attachment density affects NanoBEADS’ growth rate
and motility in an NP size-dependent manner. These findings will
contribute to the development of scalable and repeatable
bacteria-nanoparticle biohybrids for applications in drug delivery and
beyond.

Corresponding author(s) Email:
behkam@vt.edu
Tax Avoidance and Tax Disclosures in Corporate Social Responsibility Reports in the United Kingdom
Authors: Kao Wei-Chuan , Liao Chih-Hsien 
Published: September 2021

ABSTRACT
This study examines how a firm's tax disclosures in a CSR report are influenced by its tax avoidance behavior. Using a sample of public U.K. firms, our empirical analysis reveals that firms engaging in higher levels of tax avoidance are more likely to provide tax-specific disclosures in their CSR reports. In addition, the tax disclosures tend to be longer, contain more justification words, and contain more soft claims than hard information. Further cross-sectional analyses suggest that the positive association between tax avoidance and tax disclosures is attenuated when firms exhibit better CSR performance as well as stronger corporate governance. Collectively, our findings provide evidence that firms appear to legitimize their tax avoidance behavior by providing more tax disclosures in their communications with stakeholders.
JEL Classifications: H26; M14; M4.
Relationship of Parenting to Personal Hygiene Independency of Children Aged 5 To 6 Years
Authors: Wulandari Mutia , Ismaniar Ismaniar 
Published: September 2021

This research was motivated by the low personal hygiene independence of children's 5-6 years age in Jorong Batu Kijang, Nagari Dilam, Bukit Sundi District, Solok. This is thought to be one of the reasons because parental care at home is less than optimal. This study aims to determine whether there is a significant relationship between parental care and personal hygiene independence of children aged 5-6 years in Jorong Batu Kijang, Nagari Dilam, Bukit Sundi District, Solok. This research is a correlational quantitative research. A sample of 25 people was determined by using a simple random sampling technique from a population of 35 people. The results of the study were analyzed using the Spearman rank formula. Based on the results and processing of research data, it can be concluded that: a) parental care in Jorong Batu Kijang is not well implemented; b) the personal hygiene independence of children aged 5-6 years in Jorong Batu Kijang is categorized as less independent; c) there is a significant relationship between parental care and personal hygiene independence for children aged 5-6 years in Jorong Batu Kijang, Nagari Dilam, Bukit Sundi District, Solok. It is recommended to 1) parents to pay attention to good parenting to increase the independence of children's personal hygiene; and 2) early childhood education institutions to provide basic knowledge about children's personal hygiene and parenting methods to parents of early childhood that can be applied to train children's self-reliance at home.
The Stalinist Past in Contemporary Russian TV Serials: Reconfigurations of Memory
Authors: Sukovata Viktoriya 
Published: September 2021

Abstract
The two main issues that continue to be in the focus of hot public discussions in Russian society are the Great Patriotic War (the German–Soviet war of 1941–1945, as part of World War II) and the tragedy of Stalinism. While the Great Patriotic War was widely reflected in Soviet literature and cinema, the Stalinist issue was seldom represented in Soviet art. In the 1980s and 1990s, there was a period when Soviet and post-Soviet art contributed much to the debates on the Soviet past, and several significant anti-Stalinist films and literary works were created. Since the early 2000s, the cultural situation in Russian society has changed and nostalgia of the Soviet past has spread in the mass consciousness. The purpose of this research is to analyze how the Stalinist past is reconstructed in public memory in contemporary cinema narratives. We arrive at the conclusion that since the 2000s, public interest has drifted from images of war heroism to ordinary people’ lives under Stalin; the contemporary public interest is not the war heroes and famous victims of repressions, but the everydayness of ordinary Soviet citizens who tried to build their private lives, careers, friendships, and family relations under the conditions of pressure from the authorities, spreading fear in the society, shortage of goods, and loss of loved ones. We concentrate on several representative Russian TV serials, such as “Liquidation” (2007), “Maryina Roscha” (2012), and “Leningrad, 46” (2014–2015), because all of them are devoted to the first year of the Soviet peaceful life in different Soviet cities, such as Odessa, Moscow, and Leningrad.
Literasi Keuangan, Teknologi Sistem Informasi, Pengendalian Intern dan Kualitas Laporan Keuangan UMKM
Authors: Sularsih Hermi , Wibisono Sukarno Himawan 
Published: September 2021

The purpose of this research is to explain how financial literacy, information system technology, and internal control on the quality of financial reports in the era of the industrial revolution. The study used a descriptive quantitative method of 437 MSME in Pasuruan Regency and multiple regression analysis with primary data and purposive sampling as the method of selecting samples. The results of this research indicate that financial literacy (X1), information system technology (X2), have an effect on the quality of MSME financial reports in the revolutionary era 4.0, while internal control (X3) has an effect but is not significant on the quality of MSME financial reports in the revolutionary era 4.0.
Keywords: Financial Literacy; Information Systems Technology; Internal Controls; Quality.
Pelatihan dan Kepemimpinan Visioner dalam meningkatkan Kreativitas Pegawai di Kalimantan Tengah
Authors: Sambung Roby 
Published: September 2021

Penelitian ini bertujuan untuk menjelaskan pengaruh dari pelatihan kepemimpinan dalam membentuk kepemimpinan visioner, sehingga mampu menciptakan kreativitas pegawai, dan peran dari berbagi pengetahuan sebagai moderasi. Sampel dari survey penelitian ini yaitu 50 orang pejabat yang sedang mengikuti pelatihan dan pendidikan kepemimpinan pola baru untuk eselon III dari 30 organisasi pemerintahan Kota. Analsis data statistik dalam penelitian ini adalah dengan Struktural Equation Model –Partial Least Square (SEM-PLS), dengan software Smart PLS 3.2.7. Hasil analisis menunjukkan bahwa kepemimpinan visioner memediasi hubungan antaran pelatihan kepemimpinan dalam meningkatkan kreativitas pegawai. Berbagi pengetahuan terbukti memoderasi hubungan antara kepemimpinan visioner dan kreativitas pegawai. Penelitian ini berkontribusi terhadap pengembangan teori kepemimpinan di organisasi pemerintahan, hal ini menunjukkan bahwa pemimpin dengan gaya kepemimpinan visioner mampu meningkatkan kreativitas pegawai dalam bekerja, namun tergantung dengan perilaku berbagi pengetahuan dari pemimpin tersebut
Determinants of Organizational Citizenship Behavior of Contract Employees
Authors: Surya Ida Bagus Ketut , Kawiana I Gede Putu , Riana I Gede , Rihayana I Gede 
Published: September 2021

This study aims to analyze the effect of intrinsic motivation on job satisfaction and OCB and the effect of job satisfaction on OCB. This study also aims to analyze the indirect effect of intrinsic motivation on OCB through job satisfaction. The study was conducted at the Secretariat of the Regional People’s Representative Council (DPRD) of Badung Regency. Data were collected by means of questionnaire using five scales, distributed to 143 contract employees. Before being fully disseminated, data quality testing was carried out using SPSS 20 to ensure the questionnaire was valid and reliable. The data collected were analyzed using descriptive and inferential analysis with WarpPLS. The results shows that intrinsic motivation plays an important role in increasing job satisfaction and OCB. Additionally, job satisfaction is also proven to be able to increase OCB. Furthermore, intrinsic motivation indirectly has an important role in increasing OCB through job satisfaction.