bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Natural Compounds with Analgesic and Antiinflammatory Properties Using Machine Learning and Molecular Docking Studies
Authors: Khan Mohammad Firoz , Rashid Ridwan Bin , Rashid Mohammad A. 
Published: July 2021

Background:Natural products have been a rich source of compounds for drug discovery. Usually, compounds obtained from natural sources have little or no side effects, thus searching for new lead compounds from traditionally used plant species is still a rational strategy.Introduction:Natural products serve as a useful repository of compounds for new drugs; however, their use has been decreasing, in part because of technical barriers to screening natural products in highthroughput assays against molecular targets. To address this unmet demand, we have developed and validated a high throughput in silico machine learning screening method to identify potential compounds from natural sources.Methods:In the current study, three machine learning approaches, including Support Vector Machine (SVM), Random Forest (RF) and Gradient Boosting Machine (GBM) have been applied to develop the classification model. The model was generated using the cyclooxygenase-2 (COX-2) inhibitors reported in the ChEMBL database. The developed model was validated by evaluating the accuracy, sensitivity, specificity, Matthews correlation coefficient and Cohen’s kappa statistic of the test set. The molecular docking study was conducted on AutoDock vina and the results were analyzed in PyMOL.Results:The accuracy of the model for SVM, RF and GBM was found to be 75.40 %, 74.97 % and 74.60 %, respectively, which indicates the good performance of the developed model. Further, the model has demonstrated good sensitivity (61.25 % - 68.60 %) and excellent specificity (77.72 %- 81.41 %). Application of the model on the NuBBE database, a repository of natural compounds, led us to identify a natural compound, enhydrin possessing analgesic and anti-inflammatory activities. The ML methods and the molecular docking study suggest that enhydrin likely demonstrates its analgesic and anti-inflammatory actions by inhibiting COX-2.Conclusion:Our developed and validated in silico high throughput ML screening methods may assist in identifying drug-like compounds from natural sources.
Quality Assessment of Pre-Clinical Studies of Chimeric Antigen Receptor T-Cell Therapy Products: A Point of Focus on Safety
Authors: Maharshi Vikas , Diksha Diksha , Gupta Pooja 
Published: July 2021

Background:
Serious adverse reactions have been reported with the use of Chimeric
Antigen Receptor (CAR) T-cell therapy in a clinical setting despite the success of these products in
pre- clinical stages of development.

Objective:
We evaluated the quality of available pre-clinical safety data of CAR T-cell therapy
products.

Methods:
A 21 items safety checklist was designed specifically for CAR T-cell. Literature was
searched using search/MeSH terms in PubMed (October 2019 – February 2020). Studies were
screened from title and abstract. Original pre-clinical researches related to CAR T-cell anti-cancer
therapy were included.

Results:
Of the search results, 152 studies (3 in vivo, 39 in vitro, and 110 combined) were included.
Only 7.9% of studies were specifically designed to evaluate/ improve product safety. Eleven
studies included target antigen(s), and no study included co-stimulatory molecule(s) expressed exclusively
by the tumor tissue and/or CAR T-cells. One study used CRISPR-Cas9 for CAR gene
insertion. The use of switch-off mechanism and purity assessment of CAR T-cell products were reported
in 13.2% and 8.6% studies, respectively. Of the 113 studies with in vivo components, immuno-
competent animal models were used in 24.8%. Measurements of blood pressure, temperature,
body weight, and serum cytokines were reported in 0, 2.7, 29.2, and 27.4% studies, respectively.
The tissue distribution and CAR T-cells persistence were reported in 26.5% of studies. The surface
expression level of CAR, functional characterization of the product, and use of control were reported
in >90% of studies.

Conclusion:
The majority of the checklist parameters were not reported in the pre-clinical publications
to be adequately predictive of the safety of CAR T-cells in a clinical setting.
The New Jersey Perspective on Cannabis Legalization
Authors: Chatlos John Calvin , Petti Theodore A. 
Published: July 2021

Background:
Between 2010 and 2020, New Jersey went from treating
cannabis as an illegal substance in all circumstances to allowing medical use and
subsequently recreational use.
The Medical Marijuana Program (MMP) was originally very strict and was
progressively liberalized. After attempts to legalize recreational use failed in the
legislature, voters passed a referendum to amend the New Jersey constitution to
allow recreational use. Our objectives are to document this process and provide the
perspectives of psychiatrists treating adolescents.

Method:
We describe the legislative process and the multiple pressures for
legalization and decriminalization.

Discussion :
Issues germane to youth as a vulnerable population have been
inadequately considered by policymakers, the media, and the general population.
Greater attention to the process and outcome to mitigate this finding is needed.
The Top 102 Most Cited Publications Relevant to Dental Education
Authors: Yeung Andy Wai Kan , Tanaka Ray , Leung Wai Keung 
Published: July 2021

Background:
Growth and development in dental education globally depend on effective
experience sharing and advocation of evidence-based practice, preferably tested via vigorous peer
evaluation.

Objective:
This study aimed to evaluate the most cited dental education publications. The objectives
were to identify the most productive entities, and the most frequently investigated themes and
specialties.

Methods:
A keyword literature search was performed on 1st June 2020 to identify publications relevant
to dental education. PubMed, Scopus, Web of Science, ProQuest, and Campbell Collaboration
databases were searched. Publications that dealt with dental education were included. Irrelevant
publications were manually excluded by the authors, and disagreement was resolved by the senior
author. Bibliographic data of the top 102 entries (some with equal citation ranks) were obtained
from Scopus and analyzed using Bibliometrix and VOSviewer for characterization of recurring contributors
and themes.

Results:
The top publications included 83 original articles, 15 reviews, 3 books, and 1 online document,
written by 30 different authors, with 38 publications from dental journals not dedicated to education,
and with an average of 5.5 citations per year. The most productive author was William
Hendrickson. The most productive institutions were from Europe and the United States. There
were 11 papers focused on operative dentistry, 9 on endodontology, 4 on special care dentistry, 2
on community dentistry, 2 on periodontology, and 2 on implantology. Within the top 102 list, 21
publications focused on the stress experienced by dental students at school. A multiple ANCOVA
indicates that citation counts in these highly cited publications are associated with a number of authors
and document types, such as “reviews/books/online document” compared with original articles
(p<0.001).

Conclusion:
Influential dental education studies were published on a variety of platforms. Over the
past 20 years, the field witnessed the emergence of highly cited reports/articles. Similar to influential
papers in various fields, the number of authors per top-cited dental education publications appeared
to be associated with high citations indicating top quality and high appreciation/acceptance
of the articles involved.
Efficacy of Telemedicine in Hypertension Care Through Home Blood Pressure Monitoring and Videoconferencing: Randomized Controlled Trial
Authors: Yatabe Junichi , Yatabe Midori Sasaki , Okada Rika , Ichihara Atsuhiro 
Published: July 2021

Background
The burden of time is often the primary reason why patients discontinue their treatment. Telemedicine may help patients adhere to treatment by offering convenience.

Objective
This study examined the efficacy and safety of telemedicine for the management of hypertension in Japan.

Methods
Patients with uncomplicated hypertension were recruited through web advertising between November 2015 and February 2017. They were then screened, stratified by office systolic blood pressure (SBP), and randomized into two groups: usual care (UC) and telemedicine. The telemedicine group used a 3G network–attached home blood pressure (BP) monitoring device, consulted hypertension specialists from an academic hospital through web-based video visits, and received prescription medication by mail for 1 year. The UC group used the same BP monitoring device but was managed using self-recorded BP readings, which included their diary entries and office BP taken in a community practice setting.

Results
Initial screening was completed by 99 patients, 54% of whom had untreated hypertension. Baseline BP was similar between the groups, but the weekly average SBP at the end of the 1-year study period was significantly lower in the telemedicine group (125, SD 9 mmHg vs 131, SD 12 mmHg, respectively; P=.02). SBP in the telemedicine group was 3.4 mmHg lower in the morning and 5.8 mmHg lower in the evening. The rate of SBP control (135 mmHg) was better in the telemedicine group (85.3% vs 70.0%; P=.01), and significant adverse events were not observed.

Conclusions
We present evidence suggesting that antihypertensive therapy via home BP telemonitoring and web-based video visits achieve better BP control than conventional care and is a safe treatment alternative that warrants further investigation.

Trial Registration
UMIN-CTR UMIN000025372; https://tinyurl.com/47ejkn4b
Ornithological Mythologeme Falcon in «The Tale of Igor’s Campaign» and Ancient Chinese Literature
Authors: Wang  Yu , Shelemova A. O. , Kovalenko A. G. 
Published: July 2021

The image of a falcon in “The Tale of Igor’s Campaign” and ancient Chinese literature is analyzed. The material for the study was the original text of “The Tale”, its translations and comments to them by Chinese literary scholars Wei Huangnu and Li Xiyin, as well as famous ancient Chinese works. One of the main motives of the artistic and pictorial ornithology of “The Tale” is examined in detail — the individual and personal images of the falcons-Russian princes, opposing the spontaneity, chaos of the bird flock as an enemy horde. In ancient Chinese literature, the ornithological figurative complex serves as a symbol, firstly, of elite divisions, strong troops; secondly, a person filled with high motives, both heroic and career ambitious; thirdly, the authority of the monarch or some other important person in power. The novelty of the research is seen in the fact that for the first time the mythologeme falcon of “The Tale” is considered in intertextual comparison with the works of ancient Chinese literature. It is concluded that the symbolic connotations of the falcon both in ancient Chinese literature and in “The Tale of Igor’s Campaign” are closely related to the real qualities of this bird’s behavior in its natural environment: bravery, courage, dexterity.
Ethical Traditions of Adyghe: Genre Criteria and Main Motives
Authors: Kudaeva Z. Zh. , Paranuk K. N. , Golodova A. P. 
Published: July 2021

The task is to study ethical legends considered as one of the specific genre varieties of the Adyghe historical prose. The relevance of the research is due to the urgent need to create a genre classification of the Adyghe non-fairytale prose. It is noted that in this regard, the study of ethical traditions is one of the necessary stages in solving this problem. The main goal of the article is to determine genre features and main functions, to identify the main motives and images inherent in ethical legends. Cultural-historical and comparative-historical research methods are used. The socio-historical conditions and factors that contributed to the emergence of the genre of ethical legends are analyzed, various groups of legends are identified, the process of transformation of moral and ethical principles and norms is traced, the most productive plot-forming motives are determined. It is shown that the differentiating feature of ethical traditions is their cognitive and socioregulatory functions. It is argued that their main goal is to represent ideal forms and standards of interpersonal behavior, which should contribute to the formation and approval of moral, ethical and etiquette norms that existed in the Adyghe traditional society.
Bakhtin, Russia and World: Reception of Scientist’s Ideas and Works in 1996—2020 Research
Authors: Osovsky O. E. , Dubrovskaya S. A. 
Published: July 2021

The process of reception of M. M. Bakhtin’s scientific heritage over the past 25 years is analyzed in the review article. The focus of the authors is on identifying the stages and main directions, trends and achievements of modern Russian Bakhtin studies, determining the prospects for further research. The relevance of the review lies in the need for an objective reconstruction of the process of studying the ideas and heritage of M. M. Bakhtin in Russia and abroad, primarily over the past 25 years. It is noted that the works of M. M. Bakhtin are the most cited in scientific literary criticism and Bakhtin studies have become an independent branch of interdisciplinary research. The analysis revealed the role in the development of Russian Bakhtin studies of such a phenomenon as a collection of works by a scientist, Bakhtin studies journals and publications, publications of leading researchers. Conclusions are made that in 1996—2020 Russian Bakhtin studies have reached a fundamentally new level in the development of the scientist’s heritage, made a significant contribution to the study of his key ideas and concepts, completed a preliminary reconstruction of his scientific biography, carried out a systematic description of his terminological language and scientific theory as a whole, indicated the points of the necessary dialogue between Russian scientists and foreign colleagues.
Semantics of Mythological Image of Yuryung Aiyy Toyon in Its Fundamental Principle (Archaic Texts of Olonkho)
Authors: Satanar M. T. 
Published: July 2021

The question is raised about the correlation of mythological ideas with scientific information and the corresponding object of reality. It is noted that, the cognitive potential of myths continues to remain inaccessible to the perception of a modern person due to his metaphorical language. The novelty of the research is seen in an attempt to verify the semantics of the mythological image of Yuryung Aiyy Toyon in natural science discourse. The research involves a general scientific synergetic approach, lexical-semantic, contrastive-comparative, structural-semantic types of analysis, the method of mutual interpretation. In addition, special methods of depersonification, demetaphorization, and dehyperbolization of the mythological image were applied. Particular attention is paid to isolating the initial meaning of the lexeme үрүҥ — the component that generates the semantic space of the name Yuryung Aiyy Toyon. As a result of a comparative analysis, the essential content of the mythological image of a single origin and the supreme creator Yuryung Aiyy Toyon is revealed in a new light, as a basic concept of the existence of the universe from the point of view of modern science — light, the spread of which is a key factor in determining the fundamental categories of the flow of time and the length of space.
Implementation of Repression Policy in Kirghiz SSR in 1937—1938
Authors: Abdrakhmanov B. D. , Altymyshova Z. A. 
Published: July 2021

The issue of the implementation of repressions against the “Trotskyists”, “Zinovievites”, “Rightists” and other “enemies of the people” living in the Kirghiz SSR in 1937—1938 is examined in the article. Both objective and subjective prerequisites for the punitive activities of the security agencies in the first years of Soviet power are considered. The relevance of the study is due to the interest of scientists and the public in the period of Stalinist repressions, the assessment of these events. The study was carried out on the basis of materials from the archives of the State Committee for National Security. The novelty of the research is due to the fact that these documents are introduced into scientific circulation for the first time. In addition, statistics are provided on some categories of repressed in the republic, which are also published for the first time. A rethinking and political assessment of the events of this difficult period is proposed. The repressive activities against the so-called “enemies of the people” in the political aspect are analyzed, since the special services were an instrument of the ruling party and obeyed. The role and place of the security agencies, the mechanism for implementing repressions and illegal methods of conducting investigations based on archival documents of the State Committee for National Security of the Kyrgyz Republic are shown.
Russian Lawyers of Second Half of 19th Century on Political and Legal Concepts of Catherine II
Authors: Adonyeva I. G. 
Published: July 2021

The views of Russian lawyers of the second half of the 19th century regarding the political and legal concepts of Catherine II are considered. Attention is paid to educational and scientific works on the history of Russian law and Russian state law, published in the second half of the 19th century. The author proceeds from the fact that professional and class factors influenced the assessment of the empress’s political and legal ideas by Russian lawyers. It is shown that the professional one consisted in the official introduction by Catherine II into the Russian political and legal turn of the achievements of European educators, contributing to the formation of a tendency towards the prevalence of the law over the will of the monarch. Particular attention is paid to the fact that most of the representatives of the legal profession were of noble origin, the 18th century was a relatively recent past for them, and family traditions and class identity formed a positive idea of Catherine’s rule and the empress herself. At the same time, it is shown that researchers associated with the merchants paid attention to the fact that the empress’s selective acquaintance with the works of European thinkers left her without attention to branches of law, for example, civil law, which was of fundamental importance for the estate employed in commerce and industry. The author notes that historians of law paid maximum attention to the state-legal concepts of the empress. It is proved that the conclusions made in the study correlate with the ambiguous assessments of Catherine II both among historians and Russian society as a whole.
Flax Growing in Tyumen Region: History of Formation and Development in XX Century
Authors: Aksarin V. V. , Korolev K. P. 
Published: July 2021

The aspects of the origin, formation and development of the flax-growing industry in the Tyumen region in the ХХ century are considered. Based on the available historiographic material (articles, reports, essays, descriptions, statistical information), the authors identified the features of the formation of the industry. It is noted that the historical conditions in which the Tobolsk (Tyumen) province was located, later the region, throughout the XX century, were full of contradictions and difficulties. It is argued that, having good potential, having received an impetus for development in the middle of the last century, at present, flax growing has not become one of the most important sectors of the economy. It is shown that the publications of the Tobolsk Provincial Statistical Committee: “Reviews of the Tobolsk Governorate”, “Reviews of the Tobolsk Governorate in the Agricultural Relationship”, the works of N. L. Skalozubova — reveal the state of agricultural life of the population of the province, the research potential of the Tyumen experimental station, the advanced experience of agricultural enterprises, allow to identify the main problems and prospects for growing flax in the region. The productivity of flax in various agro-ecological zones of the region, varietal potential and the degree of its realization, taking into account climatic features over a long period, the economic feasibility of growing both fiber and oil-bearing forms are analyzed. The main stages of development of flax growing and limiting factors for the production of high-quality flax products are identified.
Printing House of Ministry of Internal Affairs of Russian Empire in Mid-19th — Early 20th Centuries: structure, functions, personnel
Authors: Veremenko V. A. , Krylova E. N. 
Published: July 2021

The general characteristics of the government printing house that served the interests of Ministry of Internal Affairs in the middle of the 19th and the beginning of the 20th centuries, from the moment the printing house was created in 1836 until the 1910s, when the government was forced to join the struggle for public opinion. The staff of the printing house of the Ministry of Internal Affairs, its structure and changes in personnel and functions are investigated. It is shown that the outbreak of the First Russian Revolution accelerated the transformation of the printing house of the Ministry of Internal Affairs from an institution dealing with printing works on the document circulation of the Ministry of Internal Affairs into a structure that performs important functions in the ideological struggle for public opinion. It is proved that at the beginning of the twentieth century the priority direction for the printing house of the Ministry of Internal Affairs was the task of printing government newspapers “Government Bulletin”, “Russian State”, “Evening addition to the Government Bulletin”, etc. The difference between the servants and the workers of the printing house of the central state institution is emphasized. It is noted that if the servants of the printing house of the Ministry of Internal Affairs initially had the right to receive a social package, then the workers of the printing house had to earn this right.
Responsibility for Sacrilege in Russian Empire of 19th — early 20th Centuries (Law and Enforcement)
Authors: Solnyshkin A. A. , Korneva N. M. 
Published: July 2021

The article deals with the history of relations between the Orthodox Church and the state and society. The importance of the religious component as a factor that played one of the key roles in the relationship between the state and society in Russia in the 19th — early 20th centuries is emphasized. The history of the development of responsibility for crimes against faith is traced. Particular attention is paid to this type of religious crime as sacrilege. The definition of “sacrilege” is given as a property encroachment directed at sacred or consecrated objects, as well as at church property. A detailed description of this type of crime is given and, using examples of judicial precedents of the law enforcement practice of the Russian Empire of the 19th century, its features are shown. The novelty of the study lies in the fact that it traces the evolution of the concept of “sacrilege” in Russian legislation of the 19th — early 20th centuries and determines the main trends in the field of law enforcement in relation to these crimes. It is proved that, despite the all-Russian tendency to gradually mitigate punishments for committing many religious crimes at the beginning of the 20th century, mitigation of responsibility in relation to sacrilege did not happen.