bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Adaptable Structure of Metal‐Organic Framework Glass Interlayer Enables Superior Performance in Aqueous Zinc‐Ion Batteries
Authors: Jiang Zhenjing , Zhang Yanfei , Ravnsbæk Dorthe Bomholdt , Gao Chengwei , Christensen Nanna Bjerre , Cui Fuhan , Pan Rui , Luo Kailin , Zhang Guoju , Zhang Wei , Lei Shuangying , Sun Litao , He Guanjie , Yin Kuibo , Yue Yuanzheng 
Published: December 2024

AbstractThe practical application of safe and cost‐effective aqueous zinc‐ion batteries is enhanced by the metal‐organic frameworks (MOFs), which possess tunable porous structures and chemical compositions that can facilitate the desolvation and transport of Zn2+ ions at the anode interface. However, ensuring the structural stability and operational life of crystalline MOFs in batteries remains a challenge. Here, a breakthrough is presented in tackling this dilemma. A MOF glass interlayer, specifically the ZIF‐62 glass interlayer, is designed and fabricated for the Zn anode. The integration of this interlayer endows the Zn anode with a remarkable cyclic lifespan. It also achieves outstanding cyclability in Zn||MnO2 full‐cell with limited Zn excess, showing no capacity decay after 600 cycles at 0.5 A g−1, and in a Zn||iodine pouch battery with a mass loading of 12.85 mg cm−2. This superior cyclicity is attributed to the ease of distortion of Zn[ligand]4 tetrahedra and the reduced likelihood of disconnection between adjacent tetrahedra within the glass interlayer, as compared to its crystalline counterpart. The unique structure of ZIF‐62 glass provides an increased degree of configurational freedom, allowing it to withstand mechanical stress and extend the Zn2+ ion diffusion pathway. This ensures high cycling stability and rapid interfacial diffusion kinetics.
A Universal Strategy to Mitigate Microphase Separation via Cellulose Nanocrystal Hydration in Fabricating Strong, Tough, and Fatigue‐Resistant Hydrogels
Authors: Wang Siheng , Yu Zhengyang , Sun Xia , Panahi‐Sarmad Mahyar , Yang Pu , Zhu Penghui , Zhu Yeling , Liu He , Jiang Feng 
Published: December 2024

AbstractAs a common natural phenomenon, phase separation is exploited for the development of high‐performance hydrogels. Using supersaturated salt to create microphase‐separated hydrogels with strengthened mechanical properties has gained widespread attention. However, such strengthened hydrogel loses its intrinsic flexibility, making the phase separation strategy unsuitable for the fabrication of stretchable and tough hydrogels. Here, a phase‐engineering design strategy is introduced to produce stretchable yet tough hydrogels using supersaturated NaAc salt, by leveraging the hydration effect of cellulose nanocrystal (CNC) to mitigate microphase separation. The CNC‐mitigated microphase‐separated hydrogel presents unprecedented mechanical properties, for example, tensile strength of 1.8 MPa with a fracture strain of 4730%, toughness of 43.1 MJ m−3, fracture energy of 75.4 kJ m−2, and fatigue threshold up to 3884.7 J m−2. Furthermore, this approach is universal in synthesizing various microphase separation‐enhanced polymer gels, including polyacrylic acid, poly(acrylic acid‐co‐acrylamide), gelatin, and alginate. These advancements provide insights into the incorporation of CNC‐mediated microphase separation structures in hydrogels, which will foster the future development of high‐performance soft materials.
Fluorine‐Free, Auger‐Resistive, and UV‐Emitting MXene Quantum Dots
Authors: Sharbirin Anir S. , Fadli Afrizal L. , Ariffin Annas S. , Tran Trang Thu , Lee Hyoyoung , Duong Dinh Loc , Kim Jeongyong 
Published: December 2024

AbstractMXene quantum dots (MQDs), in contrast to their precursor metallic MXenes, display photoluminescence (PL), and with the advantages of non‐toxicity, ease of synthesis, and low cost, they are promising quantum materials for optoelectronic and photonic devices. However, as‐synthesized MQDs suffer from low quantum yield (QY) and a large Stokes shift, limiting efficient UV emission, and are subject to Auger recombination, that is, a severe decline of QY and PL lifetime with increasing exciton density. Here, fluorine‐free Ti2N MQDs are synthesized using a single‐step solvothermal process, which emits UV light of a peak wavelength of 370 nm with a greatly improved QY of 17.4%, and superior resistance to Auger recombination. Band structure calculations and X‐ray photoelectron spectroscopy measurements indicate that Ti2N MQDs synthesized by using the solvothermal process are free of fluorine which is normally prevalent on the surfaces of MQDs prepared by an ordinary hydrothermal process. The results shed light on the mechanism of improving QY and mitigating Auger recombination of MQDs helping their practical applications, especially for photonic devices in the UV range.
Lanthanides‐Induced Enhancement in Self‐Trapped Excitons Emission and Anti‐Thermal Quenching of Cs2KInCl6 for Highly Sensitive Optical Thermometry
Authors: Liu Yihan , Zhang Zhichao , Mao Yingjie , Liu Kai , Xu Denghui , Liu Dan , Li Xiong , Zhou Jun 
Published: December 2024

AbstractDoping lanthanide ions in double perovskites (DPs) offers a promising approach to tailor optical and optoelectronic properties for versatile applications. However, achieving efficient and thermal stable DPs remains a significant challenge. In this paper, a series of Cs2KInCl6:Yb3+,Er3+ DPs with a negative thermal quenching behavior and high sensitivity are fabricated. The intrinsic luminescence properties of Cs2KInCl6 are studied with a broad intrinsic self‐trapped excitons (STEs) emission peak at 500 nm, which can be enhanced by doping Er3+ ions accompanied with greater distortion of the [InCl6]3− octahedrons as well as multiple characteristic emission modes of Er3+ under ultraviolet and near‐infrared excitation. Notably, the addition of sensitizer Yb3+ ions leads to the enhanced up‐conversion emission of Er3+ (up‐conversion quantum yield up to 1.66%), anti‐thermal quenching performance brought by the phonon‐assisted energy transfer up‐conversion process, as well as high sensitivity and reproducibility based on fluorescence intensity ratio technology. This work provides an effective strategy to enhance the STEs emission of DPs and achieve efficient optical temperature sensors through lanthanide ions doping.
Structural Repair of Reduced Graphene Oxide Promoted by Single‐Layer Graphene
Authors: Guo Minghao , Yuan Hong , Ni Kun , Ye Chuanren , Pan Fei , Xiong Juan , Zhu Yanwu 
Published: December 2024

AbstractHigh‐temperature graphitization of graphene oxide (GO) is a crucial step for enhancing interlayer stacking and repairing the in‐plane defects of reduced graphene oxide (rGO) films. However, the fine control of the structural repair and reducing the energy consumption in thermal treatment remain challenges. In this study, ab‐initio molecular dynamics simulations combined with experiments are used to investigate the structural evolution of rGO upon thermal annealing, with or without the presence of single‐layer graphene (SLG). It is found that the SLG promotes the repair of the carbon honeycombed matrix and alleviates the release of carbon‐containing groups during graphitization. Further electronic analysis reveals the crucial role of charge transfer from SLG to defective graphene in strengthening the C─C bonds. The result of Raman spectroscopy matches with the simulation, demonstrating an improved repairing degree of rGO upon contacting with SLG. This study provides a deeper understanding of the graphitization and repair mechanism of rGO, which may be useful for the highly efficient preparation of high‐quality graphene films.
Combined Blockade of Lipid Uptake and Synthesis by CD36 Inhibitor and SCD1 siRNA Is Beneficial for the Treatment of Refractory Prostate Cancer
Authors: Chen Jiyuan , Yu Xiaoyan , Yang Gang , Chen Xueying , Gong Chunai , Han Lu , Wang Yujie , Wang Rong , Wang Lei , Yuan Yongfang 
Published: December 2024

AbstractDrug resistance is an important factor for prostate cancer (PCa) to progress into refractory PCa, and abnormal lipid metabolism usually occurs in refractory PCa, which presents great challenges for PCa therapy. Here, a cluster of differentiation 36 (CD36) inhibitor sulfosuccinimidyl oleate sodium (CD36i) and stearoyl‐CoA desaturase 1 (SCD1) siRNA (siSCD1) are selected to inhibit lipid uptake and synthesis in PCa, respectively. To this end, a multiresponsive drug delivery nanosystem, HA@CD36i‐TR@siSCD1 is designed. The hyaluronic acid (HA) gel “shell” of HA‐TR nanosystem can release drugs in response to the acidic tumor microenvironment and hyaluronidase, and the tumor targeting (TR) cationic micellar “core” can release drugs in response to glutathione. This multiresponsive drug release is beneficial for the exogenous inhibition of lipid uptake by CD36i and the endogenous inhibition of lipid synthesis by siSCD1. The established HA‐TR nanosystem has good tumor targeting ability and tumor penetration ability, and that HA@CD36i‐TR@siSCD1 has good synergistic effects, which can significantly restrain the growth, invasion, and metastasis of PCa. Moreover, under high‐fat conditions, the tumors are more sensitive to HA@CD36i‐TR@siSCD1 treatment, almost no accumulation of lipid droplets is observed in HA@CD36i‐TR@siSCD1‐treated tumors, with enhanced antitumor immunity. Hence, this study provides a new treatment option for refractory PCa patients, especially those with a high‐fat diet.
TRIM21 Promotes Tumor Growth and Gemcitabine Resistance in Pancreatic Cancer by Inhibiting EPHX1‐Mediated Arachidonic Acid Metabolism
Authors: Fan Xiaona , Dai Yisheng , Mo Chuanfeng , Li Hengzhen , Luan Xindi , Wang Bojun , Yang Jiani , Jiao Guangtao , Lu XiaoLin , Chen Zhuo , Liao Yuanyu , Qu Ling , Yang Huike , Lou Changjie , Liu Chao , Li Zhiwei 
Published: December 2024

AbstractPancreatic cancer (PC) progresses rapidly, and gemcitabine‐based chemotherapy has brought only limited efficacy. Identifying key drivers and therapeutic targets holds significant clinical value. In this study, through comprehensive analysis of multiple PC databases, this work identifies TRIM21 as a promising driver mediator. This work further performs loss‐ and gain‐of‐function assays for TRIM21, revealing that TRIM21 knockout inhibits tumor proliferation and gemcitabine resistance both in vitro and vivo. Lipidomics reveal that silencing TRIM21 reduce the arachidonic acid production, and inhibit ferroptosis. Mechanically, through proteomics, ubiquitomics, and liquid chromatography‐tandem mass spectrometry analysis, the key metabolic enzyme of arachidonic acid ‐EPHX1 is identified as a downstream substrate of TRIM21. TRIM21 interacts with EPHX1 through its SPRY domain and promotes ubiquitin‐mediated degradation of EPHX1 via K33‐ and K48‐linked ubiquitination at the K105 site. Given the targeting potential, this work screens Bezafibrate to block the interaction between TRIM21 and EPHX1 and validates its sensitizing effect. In summary, TRIM21 promotes tumour growth and gemcitabine resistance in PC by inhibiting EPHX1‐mediated arachidonic acid metabolism. This provides a novel and promising target for clinical treatment of PC.
Relationship Between Dietary Patterns and Blood Pressure During Adolescence: A Longitudinal Analysis From Dados Study
Authors: Fernández‐Galván Luis Miguel , Adelantado‐Renau Mireia , Beltran‐Valls Maria Reyes , Moliner‐Urdiales Diego 
Published: December 2024

ABSTRACTBackgroundPrevious research in adults has suggested that healthy dietary patterns could be an effective strategy for blood pressure (BP) control. However, during adolescence, the scientific literature examining this relationship is scarce and controversial since inverse and null associations have been reported. Thus, the aim of our study was to analyze the relationship between the level of adherence to the Mediterranean diet (MD) and consumption of fresh fruits and vegetables at baseline with changes in BP over a two‐year period during adolescence.MethodsThe analyses included 197 adolescents (92 girls) aged 13.9 ± 0.3 years. Adherence to the MD and consumption of fresh fruits and vegetables were assessed using the KIDMED questionnaire and a food frequency questionnaire, respectively. BP values were measured using an automatic sphygmomanometer according to standardized procedures.ResultsAdolescents with high adherence levels to the MD, and high consumption of vegetables (but not fruits) at baseline, showed smaller increases in diastolic BP changes over two years (percentage of reduction ranging from ~48% to ~88%, all p < 0.026). No significant relationships were identified in systolic BP over the two‐year period.ConclusionOur findings underscore the importance of promoting MD and vegetable consumption to reduce diastolic BP during adolescence, contributing to lowering future cardiovascular risk.
Carbon Dioxide Upgrading to Biodegradable Plastics through Photo/Electro‐Synthetic Biohybrid Systems
Authors: Kuang Min , Li Bingbing , Zhou Linjiao , Huang Zichao , Wu Jing , Wang Shaobin , Yang Jianping 
Published: December 2024

AbstractThe escalating emissions of anthropogenic carbon dioxide (CO2) and the pervasive issue of nondegradable plastic pollution underscore dual urgent challenges in pursuit of a sustainable society. Achieving such sustainability in the plastic industry, while effectively addressing these environmental concerns, necessitates the development and implementation of innovative strategies for the synthesis of biodegradable polymers utilizing CO2 as feedstocks. The technologies not only facilitate the mitigation of elevated atmospheric CO2 concentrations but also introduce a renewable carbon resource for polymer manufacturing. While considerable research has been undertaken in CO2 upgrading to various C1‐3 products, the production of biodegradable polymers from CO2 remains a formidable challenge. Here, we delineate the principal methodologies for catalytic CO2 upgrading to biodegradable polymers, encompassing photocatalytic‐biological processes and electrocatalytic‐biological approaches. The emphasis of this perspective is on the optimization of production processes and catalyst efficiency, which are paramount in addressing the imperative challenge of decarbonization in the plastic industry, thereby aligning with global environmental sustainability goals.
From moral condemnation to acceptance, compassion and understanding of context: Reflections on practice principles supporting healing in families from refugee and asylum seeker backgrounds
Authors: Caveny Katherine , Tipping Susannah , Rezaei Elham , Akimana Septime , Brooks Harrison , Flihan Rima , Khanijou Suphawan (Saakshi) , Kuyang Magdalena , McBride Kathleen , Mitchell Elizabeth , Paulsen Catalina , Mangubat Ruchi , Mufambali Imani Safi , Sakaria Consy 
Published: December 2024

AbstractInformed by participatory action research methodology, this article adopts a unique collaborative co‐writing process providing a means for practitioners of diverse cultural and professional backgrounds to share and reflect on family work, including but not limited to family therapy, happening across a specialist torture and trauma recovery service. Through exploring historical and contemporary ways of working with families at the Queensland Program of Assistance to Survivors of Torture and Trauma, an agency providing support to people from refugee backgrounds, some common practice principles were identified as well as key theories and frameworks underpinning collective family work. Guiding principles identified include: the need for a systemic lens, flexibility in service delivery, building safety and trusting relationships, cultural humility and valuing lived experience, recognising complexity and avoiding assumptions, and listening and responding to client and community needs. In moving away from moral condemnation, the article underscores the value of thinking systemically and abiding by recognising each family's unique story and the need for culturally sensitive interventions. Ongoing opportunities to connect over practice are considered valuable for practitioners engaged in different types of family work.
Development of pH‐Responsive Hydrogel Excipient From Karaya Gum for Improved Oral Delivery of Donepezil Hydrochloride in Alzheimer's Disease Treatment
Authors: Avvadukkam Jayashree , Kodoth Arun Krishna , Subramani Thency Monnikanda , Bhandari Sukesh Ganesh , Kaiprath Dhyana , Kunhanna Sarojini Balladka , Venugopal Deepa Mugudthi , Raghu Shamprasad Varija 
Published: December 2024

ABSTRACTThe present study focused on fabricating an efficient excipient for donepezil HCl from karaya gum as the base material. The karaya gum was grafted and crosslinked with N‐isopropyl acrylamide and N,N′‐methylene(bis)acrylamide, respectively, using microwave. The successful fabrication of the resulting hydrogel was confirmed and characterized by FTIR, FESEM, and TGA analyses. Remarkably, the synthesized gel exhibited distinct swelling behavior in different pH mediums ranging from 1.2 to 13. As expected, the gel exhibited an impressive 96% release of donepezil, a widely used hydrophilic drug for treating Alzheimer's disease, in a buffer solution of pH 1.2, within a 48‐h timeframe. Kinetic studies further revealed that drug release from the gel aligns with the Higuchi model. Cytotoxicity studies using
Drosophila melanogaster
as a model system showed the biocompatible nature of the excipient. This characteristic highlights its potential application as a drug carrier for the oral delivery of Donepezil HCl in treating Alzheimer's disease.
Vascular‐Associated Mononuclear Phagocytes: First‐Line Soldiers Ambushing Metastasis
Authors: Huang Han‐ying , Zheng Xin‐nan , Tian Lin 
Published: December 2024

ABSTRACTMononuclear phagocytes (MPs), which consist of dendritic cells, monocytes, and macrophages, are distributed throughout the body and actively eliminate invading microorganisms and abnormal cells. Depending on the local microenvironment, MPs manifest considerably various lifespans and phenotypes to maintain tissue homeostasis. Vascular‐associated mononuclear phagocytes (VaMPs) are the special subsets of MPs that are localized either within the lumen side or on the apical surface of vessels, acting as the critical sentinels to recognize and defend against disseminated tumor cells. In this review, we introduce three major types of VaMPs, patrolling monocytes, Kupffer cells, and perivascular macrophages, and discuss their emerging roles in immunosurveillance during incipient metastasis. We also explore the roles of lineage‐determining transcription factors and cell surface receptors that endow VaMPs with potent anti‐tumor activity. Finally, we highlight the molecular and cellular mechanisms that drive the phenotypic plasticity of VaMPs and summarize combinatory strategies for targeting VaMPs in overt metastasis.
Ecologic and Economic Evaluation of Combined Methanol Synthesis from CO2 and Biotechnological Upgrading to Value Products. Part 1: Environmental Impact
Authors: Taherkhani Mehran , Hanau Niels , Lehmpfuhl Rebecca , Ehret Ralf 
Published: December 2024

AbstractThe conversion of waste biomass with green hydrogen into methanol and subsequent biotechnological conversion of this into valuable materials could be a promising value chain. Starting from biogenic CO2 and green H2, methanol is produced in a first process path. This is then split into two separate process paths: methanol is used (i) in a biotechnological process with genetically modified bacteria to produce crotonic acid and (ii) to produce biomass protein. To evaluate the ecologically and economic benefits of both biological processes to the conventional production routes, first life cycle assessment and techno‐economic assessment of biotechnological and chemical processes are accomplished. For this, a baseline scenario and several scenarios are calculated to investigate the influence of various parameters on environmental impact and economic efficiency. The results also identify the processes that are mainly responsible for costs and environmental impact, as well as the material, energy and waste flows, and process parameters that cause them. From this, measures and conditions for improving economic efficiency and environmental impact are derived.
Patients with detectable KIT p.D816V in peripheral blood are at high risk for adverse systemic events during venom immunotherapy and treatment failure
Authors: Luzar Ajda Demšar , Otorepec Jakob , Košnik Mitja , Kopač Peter , Šelb Julij , Korošec Peter , Rijavec Matija 
Published: December 2024

AbstractBackgroundRecent studies have highlighted the importance of routine screening for the somatic missense KIT p.D816V variant in peripheral blood leukocytes (PBL), and its association with severe sting anaphylaxis. Our study aimed to evaluate the clinical relevance of KIT p.D816V detected in PBL on systemic adverse events (SAEs) and the efficacy of venom immunotherapy (VIT).MethodsThis retrospective study included 839 patients receiving VIT. The KIT p.D816V variant was assayed with a highly sensitive, allele‐specific, quantitative PCR.ResultsKIT p.D816V was detected in the PBL of 125 (15%) of 839 VIT patients. The majority (70%, 88/125) of these individuals had normal BST levels. Notably, half of the KIT‐positive patients receiving honeybee venom immunotherapy had SAEs during treatment (48%, 18/37; p = 0.0136), and the KIT p.D816V allele burden was higher than 0.01% in the majority of those patients (61%, 11/18). Furthermore, a significant difference was observed between KIT‐positive and KIT‐negative patients treated with VIT in the past and who experienced a recurrent reaction to a sting after treatment termination (VIT failure). KIT‐positive patients with VIT failure had a higher allele burden than those with successful VIT (80% vs. 40% with a KIT p.D816V higher than 0.01%; p = 0.0019). KIT p.D816V was a predictor of SAEs during honeybee VIT (univariate; OR = 2.43, p = 0.012/multivariate; OR = 2.26, p = 0.033) and a strong predictor of VIT failure in patients treated with wasp venom (univariate; OR = 4.1, p = 0.002/multivariate; OR = 3.54, p = 0.008).ConclusionOur study revealed the high clinical relevance of KIT p.D816V detected in PBL. KIT p.D816V was a significant predictor of SAEs during honeybee VIT and a significant predictor of VIT failure after completing wasp VIT.