bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the perception of halal tourism destination matter for non-Muslim tourists’ WOM? The moderating role of religious faith
Authors: Rahman Muhammad Khalilur , Rana Md Sohel , Ismail Mohd Nazari , Muhammad Mohd Zulkifli , Hoque Muhammad Nazmul , Jalil Md. Abdul 
Published: September 2021

Purpose
Tourists often travel to different tourism destinations in advancing the knowledge of diverse cultures, environments, history and social aspects. The purpose of this study is to explore tourists’ perception of halal tourism and its impact on word-of-mouth towards halal tourism destinations.

Design/methodology/approach
A quantitative research approach was applied in this study. Data were collected via 375 survey questionnaires and were analysed using partial least square method. Data were collected from Malaysia’s capital city and tourist spots in Kuala Lumpur, the administrative capital city in Putrajaya, and several cities in Selangor, the richest state in the country.

Findings
The findings revealed that trip quality has a higher significant impact on satisfaction and trip value. The perception of a halal tourism destination is found to have a significant influence on satisfaction and trip value. Trip value is significantly related to satisfaction but not associated with word-of-mouth (WOM). Satisfaction of tourists has a significant impact on WOM towards travel destinations.

Research limitations/implications
This study comes up with a novel understanding of the theory of tourism practices by estimating non-Muslim tourists’ perception and its significant influence of WOM towards tourism destinations. The results of this study are significant to industry practitioners, policymakers and marketers in promoting halal tourism. The results of this study provide useful insights for Malaysia’s tourism industry, particularly for the tourism marketing in Kuala Lumpur and Putrajaya cities as tourist destinations.

Practical implications
This study comes up with a novel understanding of the theory of tourism practices by estimating non-Muslim tourists’ perception and the influence of WOM towards tourism destinations. The results of this study are significant to industry practitioners, policymakers and marketers in promoting halal tourism.

Originality/value
This study examined the potential impact of non-Muslim tourists’ perception of halal tourism destinations and their WOM for halal tourism destinations.
Model selection in time series analysis: using information criteria as an alternative to hypothesis testing
Authors: Hacker R. Scott , Hatemi-J Abdulnasser 
Published: September 2021

PurposeThe issue of model selection in applied research is of vital importance. Since the true model in such research is not known, which model should be used from among various potential ones is an empirical question. There might exist several competitive models. A typical approach to dealing with this is classic hypothesis testing using an arbitrarily chosen significance level based on the underlying assumption that a true null hypothesis exists. In this paper, the authors investigate how successful the traditional hypothesis testing approach is in determining the correct model for different data generating processes using time series data. An alternative approach based on more formal model selection techniques using an information criterion or cross-validation is also investigated.Design/methodology/approachMonte Carlo simulation experiments on various generating processes are used to look at the response surfaces resulting from hypothesis testing and response surfaces resulting from model selection based on minimizing an information criterion or the leave-one-out cross-validation prediction error.FindingsThe authors find that the minimization of an information criterion can work well for model selection in a time series environment, often performing better than hypothesis-testing strategies. In such an environment, the use of an information criterion can help reduce the number of models for consideration, but the authors recommend the use of other methods also, including hypothesis testing, to determine the appropriateness of a model.Originality/valueThis paper provides an alternative approach for selecting the best potential model among many for time series data. It demonstrates how minimizing an information criterion can be useful for model selection in a time-series environment in comparison to some standard hypothesis testing strategies.
A novel design space concept for design of concrete foundation supporting chemical reactors
Authors: Bedair Osama 
Published: September 2021

PurposeThis paper presents a novel concept for design of concrete support system for chemical reactors used in refineries and petrochemical plants. Graphical method is described that can be used to size the concrete base and piling system. Recommendations are also provided to optimize the parameters required for the design. The procedure is illustrated for design of two reactor models commonly used in gas recovery units.Design/methodology/approachDesign space representation for the foundation system is described for chemical reactors with variable heights. The key points of the design graph are extracted from the numerical finite element models. The reactor load is idealized at discrete points to transfer the loads to the piles. Bilateral spring system is used to model the soil restrains.FindingsThe graphical approach is economical and provides the design engineer the flexibility to select the foundation parameters from wide range of options.Practical implicationsThe concept presented in the paper can be utilized by engineers in the industry for design of chemical reactors. It must be noted that little guidelines are currently available in practice addressing the structural design aspects.Originality/valueA novel concept is presented in this paper based on significant industrial design experience of reactor supports. Using the described method leads to significant cost savings in material quantity and engineering time.
On the validity of longitudinal comparisons of central location consumer testing results prior to COVID‐19 versus home use testing data during the pandemic
Authors: Shi Menghan , Stelick Alina , Licker Susan , Dando Robin 
Published: September 2021

AbstractConsumer testing assays a panel's liking of a food or other sensory stimulus. However, liking can be influenced by mood, with people feeling more uncomfortable, or more unhappy reporting lower liking ratings than those in a higher affect. Though consumer testing typically takes place as a central location test (CLT, usually in a set of standardized sensory booths), the COVID‐19 pandemic has resulted in a global pivot to home use tests (HUTs), where panelists can taste and smell samples unmasked more safely while in their own homes. Unfortunately, as this situation differs in many ways to a central location test, this puts the validity of longitudinal comparisons of liking scores under question. Further, as people across the globe report feelings of worry, unease, and stress during the pandemic, this may present a second source of variation in affect with previous years. We tested a set of snack bar samples both at home and in a central location, in repeated measures with the same panel, to test the validity of comparisons across locations. We further compared CLT results to those when testing the same samples in a previous year. Finally, we performed a meta‐analysis of existing data on this subject. While liking behavior in CLTs did not differ between years, panelists rated some samples higher when in their own homes, in line with results from the meta‐analysis of previous reports. Interestingly, panelists in the study also assigned fewer penalties in the HUT, implying a less analytical mindset when in the home. Results suggest that care should be taken when comparing results taken at home during the COVID‐19 pandemic to those taken previously in a central location.Practical ApplicationConsumer testing is applied in the food industry to evaluate a panelist's liking for a food product or stimulus. However, liking is also dependent on factors extrinsic to the samples tested. Thus, with the switch to in‐home testing due to COVID‐19, we compared liking scores from in‐home and central locations testing, with higher scores common in HUTs.
CTLA‐4 polymorphisms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis
Authors: Louthrenoo Worawit , Kasitanon Nuntana , Wongthanee Antika , Kuwata Shoji , Takeuchi Fujio 
Published: September 2021

AbstractAimsStudies on polymorphisms of the cytotoxic T lymphocytes associated antigen‐4 (CTLA‐4) genes in rheumatic disease patients are limited in Southeast Asia. This pilot study aimed to determine CTLA‐4 polymorphisms in Thai patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), and correlate them with serology.MethodOne‐hundred RA, 70 SLE and 50 SSc patients, and 99 healthy controls (HCs) were included in this study. Polymorphisms of the CTLA‐4 gene at +49A/G, −318C/T, −1661A/G and −1722T/C loci were determined by polymerase chain reaction restriction fragment length polymorphism methods. Patient serum samples were determined as follows: RA (rheumatoid factor [RF] and anticyclic citrullinated peptide [anti‐CCP]), SLE (antinuclear antibodies [ANA], anti‐double‐stranded DNA [anti‐dsDNA], anti‐Smith [anti‐Sm], anti‐ribonucleoprotein [anti‐RNP], and anti‐Sjögren’s syndrome antigen A [SSA]), and SSc (ANA, anti‐RNP, anti‐SSA, anti‐topoisomerase‐1 [anti‐Scl70], and anti‐centromere antibodies [ACA]).ResultsAmong the 4 loci studied (+49A/G, −318C/T, −1661A/G and −1722T/C) only the A allele frequency at the +49A/G was significantly higher in the RA patients than their HCs (47.25% vs 35.86%, P = .029, odds ratio [OR] 1.60; 95% CI 1.04‐2.47). It also was significantly higher in the subgroup of RA patients with positive RF and anti‐CCP than their HCs (47.50% vs 35.86%, P = .020, OR 1.62; 95% CI 1.06‐2.47 and 48.89% vs 35.86%, P = .012, OR 1.71; 95% CI 1.11‐2.64, respectively). No polymorphisms at these 4 loci were observed in SLE or SSc patients.ConclusionThe A allele at +49A/G locus of the CTLA‐4 gene was associated with RA in Thais.
Viral infection in thymoma and thymic tumors with autoimmune diseases
Authors: Chang Rui , Duan Shuning , Li Shicong , Zhang Peng 
Published: September 2021

AbstractA thymoma is a type of thymic tumor which is rarely malignant that is frequently reported in adult patients. A number of thymoma‐related immune disorders are observed including autoimmune diseases, which suggests a strong connection between thymoma development and immunological mechanisms. Characterized by association with humoral and cellular immunodeficiency, thymoma patients are susceptible to opportunistic infections by environmental factors. Recent reports have suggested that viral infection may play a role in the etiological mechanisms of thymoma development associated with dysregulated immunity. In this review, we summarize the case reports and studies related to viral infection, such as CMV, EBV and HSV, that probably play a part in the pathogenesis of thymoma and related diseases. Furthermore, we demonstrate the underlying mechanisms by which viruses may induce the occurrence of thymoma with autoimmune diseases. Lastly, we discuss the potential application of antiviral therapy in the treatment of thymic diseases.
Alcohol use disorder in the COVID‐19 era: Position paper of the Italian Society on Alcohol (SIA)
Authors: Testino Gianni , Vignoli Teo , Patussi Valentino , Allosio Pierluigi , Amendola Maria Francesca , Aricò Sarino , Baselice Aniello , Balbinot Patrizia , Campanile Vito , Fanucchi Tiziana , Macciò Livia , Meneguzzi Cristina , Mioni Davide , Parisi Michele , Renzetti Doda , Rossin Raffaella , Gandin Claudia , Bottaro Luigi Carlo , Caio Giacomo , Lungaro Lisa , Zoli Giorgio , Scafato Emanuele , Caputo Fabio 
Published: September 2021

AbstractCoronavirus disease 2019 (COVID‐19) first emerged in China in November 2019. Most governments have responded to the COVID‐19 pandemic by imposing a lockdown. Some evidence suggests that a period of isolation might have led to a spike in alcohol misuse, and in the case of patients with alcohol use disorder (AUD), social isolation can favour lapse and relapse. The aim of our position paper is to provide specialists in the alcohol addiction field, in psychopharmacology, gastroenterology and in internal medicine, with appropriate tools to better manage patients with AUD and COVID‐19,considering some important topics: (a) the susceptibility of AUD patients to infection; (b) the pharmacological interaction between medications used to treat AUD and to treat COVID‐19; (c) the reorganization of the Centre for Alcohol Addiction Treatment for the management of AUD patients in the COVID‐19 era (group activities, telemedicine, outpatients treatment, alcohol‐related liver disease and liver transplantation, collecting samples); (d) AUD and SARS‐CoV‐2 vaccination. Telemedicine/telehealth will undoubtedly be useful/practical tools even though it remains at an elementary level; the contribution of the family and of caregivers in the management of AUD patients will play a significant role; the multidisciplinary intervention involving experts in the treatment of AUD with specialists in the treatment of COVID‐19 disease will need implementation. Thus, the COVID‐19 pandemic is rapidly leading addiction specialists towards a new governance scenario of AUD, which necessarily needs an in‐depth reconsideration, focusing attention on a safe approach in combination with the efficacy of treatment.
Clinical benefits and potential risks of adalimumab in non‐JIA chronic paediatric uveitis
Authors: Kouwenberg Carlyn V. , Koopman‐Kalinina Ayuso Viera , de Boer Joke H. 
Published: September 2021

AbstractPurposeTo describe the treatment results with adalimumab in chronic paediatric uveitis, not associated with juvenile idiopathic arthritis (JIA).MethodsMedical records of children with non‐JIA‐uveitis were reviewed retrospectively. Children without an underlying systemic disease were pre‐screened with brain magnetic resonance imaging (MRI) to exclude white matter abnormalities/demyelination.ResultsTwenty‐six patients were pre‐screened with brain MRI, of whom adalimumab was contraindicated in six patients (23%) with non‐anterior uveitis. Forty‐three patients (81 eyes) were included. Disease inactivity was achieved in 91% of the patients after a median of three months (3–33). Best‐corrected visual acuity (BCVA) improved from 0.16 ± 0.55 logarithm of the minimum angle of resolution (logMAR) at baseline to 0.05 ± 0.19 logMAR at 24 months (p = 0.015). The median dosage of systemic corticosteroids was reduced to 0 mg/day at 24 months of follow‐up (versus 10 mg/day at baseline; p < 0.001). Adalimumab was discontinued in thirteen children due to ineffectiveness (n = 8), side effects (n = 1), long‐term inactivity of uveitis (n = 3) or own initiative (n = 1). Relapse of uveitis occurred in 19 (49%) patients, 5 (26%) of them without an identifiable cause.ConclusionAdalimumab is effective in the treatment of non‐JIA‐uveitis in paediatric patients by achieving disease inactivity in the majority of the patients, improving BCVA and decreasing the dose of corticosteroids. Adverse events and side effects are limited. Pre‐screening with MRI of the brain is recommended in paediatric patients with intermediate and panuveitis.
Pachychoroid‐phenotype effects on 5‐year visual outcomes of anti‐VEGF monotherapy in polypoidal choroidal vasculopathy
Authors: Shimizu Yuichiro , Miyata Manabu , Ooto Sotaro , Miyake Masahiro , Mori Yuki , Tamura Hiroshi , Ueda‐Arakawa Naoko , Uji Akihito , Muraoka Yuki , Takahashi Ayako , Wakazono Tomotaka , Yamashiro Kenji , Hata Masayuki , Tsujikawa Akitaka 
Published: September 2021

AbstractPurposeTo investigate whether the efficacy of anti‐vascular endothelial growth factor (VEGF) monotherapy for polypoidal choroidal vasculopathy (PCV) differs between pachychoroid and non‐pachychoroid phenotypes in the long term.MethodsThis retrospective longitudinal study included 115 treatment‐naïve eyes in 115 consecutive patients with symptomatic PCV who were treated with anti‐VEGF monotherapy and were followed up for 5 years. Eligible eyes were assigned to either a pachy‐PCV group, with a pachychoroid phenotype, or a non‐pachy‐PCV group, without a pachychoroid phenotype. Best‐corrected visual acuity (BCVA) and other parameters over a 5‐year period were compared between the groups.ResultsForty‐eight eyes and 67 eyes were classified into the pachy‐PCV and non‐pachy‐PCV groups respectively. Baseline and 5‐year BCVA (logarithm of the minimum angle of resolution) were 0.19 ± 0.20 and 0.16 ± 0.28 in the pachy‐PCV group, respectively, and 0.25 ± 0.26 and 0.26 ± 0.36 in the non‐pachy‐PCV group respectively. BCVA did not change significantly in either group (p = 0.18 and 0.08 respectively). BCVA did not differ between the groups at any observation time‐point. Subfoveal choroidal thickness (SFCT) at baseline and at 5 years was significantly higher in the pachy‐PCV group than in the non‐pachy‐PCV group (both p < 0.001); however, the mean rate of decrease in SFCT did not differ in either group over the 5‐year period (22% vs. 23%, p = 0.81).ConclusionOur findings suggest that anti‐VEGF monotherapy was similarly effective for pachychoroid‐ and non‐pachychoroid‐phenotype eyes with PCV, for at least 5 years, although further studies are required.
Investigating the provenance of iron bars from Les Saintes‐Maries‐de‐la‐Mer Roman shipwrecks (south‐east France) with iron isotopes
Authors: Milot Jean , Coustures Marie‐Pierre , Poitrasson Franck , Baron Sandrine 
Published: September 2021

AbstractFe isotopes were used to determine the origin of iron bars from Les Saintes‐Maries‐de‐la‐Mer Roman shipwrecks, which was a major archaeological finding at the end of the 20th century in France. Their Fe isotope composition was measured by multi collector‐inductively coupled plasma‐mass spectrometry (MC‐ICP‐MS) after chemical Fe purification. The results allowed us to suggest provenances that were compared with those based on trace element analyses of slag inclusions. For most of the bars, we validate the provenance hypotheses previously proposed. Two bar groups originate from the Montagne Noire metallurgical district (south‐west France), whereas a third group comes from another source, not clearly identified so far. In this context of Roman iron production, we argue for a non‐spatially segmented production, where bars were manufactured close to smelting sites. Combined trace element and Fe isotope analyses on the same objects provide crucial information about the nature of their ore source. The elemental heterogeneity, positive Eu anomaly and Fe isotopic homogeneity of several bars were inherited from gossan‐type ores, whereas the negative Eu anomaly and variable Fe isotopes signature of others most likely correspond to sedimentary iron ores. This study demonstrates that combined trace element and Fe isotopes analyses in a well‐defined archaeological context is a promising approach for provenance studies of iron metals of archaeological interest.
Exposure–response analysis of acalabrutinib and its active metabolite, ACP‐5862, in patients with B‐cell malignancies
Authors: Edlund Helena , Buil‐Bruna Núria , Vishwanathan Karthick , Wei Helen , Raman Rakesh , de Kock Miné , He Zhongqing , Liu Huan , Baek Marshall , Ware Joseph , Patel Priti , Tomkinson Helen , Sharma Shringi 
Published: September 2021

AimsExamine relationships between the systemic exposure of acalabrutinib, a highly selective, next‐generation Bruton tyrosine kinase inhibitor, and its active metabolite (ACP‐5862) vs. efficacy and safety responses in patients with B‐cell malignancies who received acalabrutinib as monotherapy or in combination with obinutuzumab.MethodsFor exposure–efficacy analyses, patients with untreated chronic lymphocytic leukaemia were assessed for best overall response, progression‐free survival and tumour regression. For exposure–safety analyses, incidences of grade ≥2 adverse events (AEs), grade ≥3 AEs and grade ≥2 events of clinical interest were assessed in patients with B‐cell malignancies. Acalabrutinib and ACP‐5862 pharmacokinetic (PK) parameter estimates were obtained from population PK modelling. Exposure calculations were based on study dosing regimens. Total active moieties were calculated to account for contributions of ACP‐5862 to overall efficacy/safety.ResultsA total of 573 patients were included (exposure–efficacy analyses, n = 274; exposure–safety analyses, n = 573). Most patients (93%) received acalabrutinib 100 mg twice daily. Median total active area under the concentration–time curve (AUC24h,ss) and total active maximal concentration at steady‐state (Cmax,ss) were similar for patients who received acalabrutinib as monotherapy or in combination with obinutuzumab, and for responders and nonresponders. No relationship was observed between AUC24h,ss/Cmax,ss and progression‐free survival or tumour regression. Acalabrutinib AUC24h,ss and Cmax,ss were generally comparable across groups regardless of AE incidence.ConclusionNo clinically meaningful correlations between acalabrutinib PK exposure and efficacy and safety outcomes were observed. These data support the fixed acalabrutinib dose of 100 mg twice daily in the treatment of patients with B‐cell malignancies.
Neural functional connectivity changes to psychosocial stress in young adults with bipolar disorder and preliminary associations with clinical trajectories
Authors: Kirsch Dylan E. , Preston Alex , Tretyak Valeria , Le Vanessa , Weber Wade , Strakowski Stephen M. , Lippard Elizabeth T. C. 
Published: September 2021

AbstractBackgroundStress‐related mechanisms are implicated in the pathophysiology of bipolar disorder and may contribute to heterogeneity in illness course. Yet, there is a lack of study investigating the neural mechanisms underlying the stress response in this condition. This study investigated changes in amygdala activation and functional connectivity in response to acute psychosocial stress in young adults with bipolar disorder and explored relations with clinical phenotype and prospective mood symptoms.Methods42 young adults [19 with bipolar disorder, agemean ± SD =21.4 ± 2.2 years] completed a modified version of the Montreal Imaging Stress Task. Amygdala activation and functional connectivity with prefrontal cortex (PFC) regions of interest was calculated for control and stress conditions. Main effects of group, condition, and group by condition interaction on amygdala activation and connectivity were modeled. A subset of bipolar participants completed 1‐year follow‐up assessments. Relations between neural responses to stress with concurrent substance use and prospective mood symptoms were explored.ResultsThere were no between‐group differences in amygdala activation or functional connectivity during the control condition. Increased right amygdala‐right rostral PFC (rPFC) functional connectivity to stress was observed in bipolar disorder, compared to typically developing controls. In bipolar disorder, greater increase in right amygdala‐right rPFC functional connectivity to stress was associated with less frequent cannabis use, and prospectively with shorter duration and lower severity of depression symptoms over follow‐up.ConclusionResults from this preliminary study suggest differences in frontolimbic functional connectivity responses to stress in young adults with bipolar disorder and associations with cannabis use and prospective mood symptoms.