bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bored by bothering? A cost-value approach to pandemic boredom
Authors: Martarelli Corinna S. , Wolff Wanja , Bieleke Maik 
Published: September 2021

AbstractIn an effort to mitigate the impact of the COVID-19 pandemic, countries around the world have employed non-pharmaceutical containment measures. The effectiveness of such mitigation efforts relies on individual compliance (e.g., avoiding to travel or to gather). Crucially, adhering to the required behavioral recommendations places substantial burdens on those who are asked to follow them. One particularly likely outcome of adherence should be the experience of boredom. Thus, people might get bored by bothering. Drawing from research and theorizing on reward-based decision making, we conducted a high-powered study (N = 1553 US participants) to investigate whether the value and effort people ascribe to adherence to containment measures directly and indirectly (i.e., mediated by adherence) affects their experience of boredom. As expected, structural equation modeling revealed that high value and low effort predicted compliance with behavioral recommendations. Moreover, higher compliance was linked to more boredom, meaning that high value and low effort increased boredom via compliance. In contrast, high value and low effort had direct effects on boredom in the opposite direction (i.e., decreasing boredom). Attesting to their robustness and generalizability, these findings held for both prospective (with respect to upcoming winter holidays) and retrospective behavior (with respect to previous thanksgiving holidays), across US states, which had or had not enforced behavioral restrictions, individual differences in boredom proneness, and demographic variables. Taken together, our results provide evidence that people can indeed get bored by bothering: Complying with nonpharmacological containment measures like avoiding to travel and to gather can come at the cost of getting bored, an experience that was strongly linked to negative affect in our study.
Fatty acid profile, oxidative stability of lipids and sensory attributes of water restricted Xhosa goat meat supplemented with vitamin C
Authors: Akinmoladun O. F. , Fon F. N. , Mpendulo C. T. , Hugo A. , Falowo A. B. , Nantapo C. T. W. 
Published: September 2021

Context Water scarcity often accompanied by limited water intake (WI) in livestock may result in pre-slaughter stress, thereby affecting meat quality parameters. Aims This study was conducted to determine the effect of vitamin C (VC) supplementations on fatty acid (FA), lipids oxidation and sensory attributes of Longissimus lumborum muscles of Xhosa goats subjected to different watering regimen. Methods In total, 42 goats were randomly assigned into seven treatments: without water restriction, WR (W0, control); WR of 70% of ad libitum WI (W70); WR of 50% ad libitum WI (W50); WR of 70% of ad libitum WI + 3 g VC daily (W70+); WR of 50% of ad libitum WI intake + 3 g VC daily (W50+); WR of 70% of ad libitum WI + 3 g VC and extra 5 g VC given every 8 days (W70++); WR of 50% of ad libitum WI + 3 g VC and extra 5 g VC given every 8 days (W50++). The goats were fed for 75 days and killed following standard procedures. Bodyweight changes, thaw loss, ultimate pH (pHu), thiobarbituric acid reactive substance (TBARS), moisture and fat content, sensory attributes and FA profile of the meat were evaluated. Key results Results indicated that the decreased final weight in the untreated groups (W70 and W50) was reduced (P > 0.05) in the treated groups (W70+, W50+, W70++, W50++). The treatment effect was not significant (P > 0.05) on pHu, thaw loss and TBARS values. The moisture and fat content in the water-restricted groups were lower (P < 0.05) than in W0. The meat sensory appearance was affected (P < 0.05) by WR. Regardless of VC concentration, vaccenic and docosahexaenoic acid increased (P < 0.05), while linolenic acid decreased as the WR levels increased. Conclusions WR of 70% and 50% of ad libitum WI, with or without VC, did not negatively affect the meat’s lipid oxidation and FA profile. Implications Limited WI reduces body weight. However, a daily dose of VC could help reduce body weight loss during water scarcity.
Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B
Authors: Carpenter Jerome , Wang Yang , Gupta Richa , Li Yuanli , Haridass Prashamsha , Subramani Durai B. , Reidel Boris , Morton Lisa , Ridley Caroline , O’Neal Wanda K. , Buisine Marie-Pierre , Ehre Camille , Thornton David J. , Kesimer Mehmet 
Published: September 2021

Significance
Gel-forming mucins, MUC5AC and MUC5B, are the essential components of the protective mucus layer of the lungs. MUC5B is crucial for lung innate defense, and MUC5AC is generally secreted disproportionately in response to cigarette smoke and allergens. MUC5AC’s role in airway defense and chronic airway disease pathogenesis and how this emerges from its macromolecular assembly/gel-making properties are not known. We demonstrate MUC5AC binds significantly more to hydrophobic surfaces and forms stiffer and more viscoelastic layers compared to MUC5B. Also, MUC5AC forms higher-order oligomers in addition to dimers. These observations may generate insight into why/how MUC5AC forms a stagnant, “tethered” mucus layer in muco-obstructive lung diseases and could guide the development of strategies to intervene with more effective therapeutic agents.
“If you follow me, I might (mis)lead you”
Authors: Ariel Yaron , Elishar Malka Vered , Weimann Saks Dana , Avidar Ruth 
Published: September 2021

Abstract
This study investigates the effects of the two leading prime ministerial candidates’ personal Facebook and Twitter
accounts and the effects of exposure to the general social media and web discourse in Hebrew on voters’ agendas during Israel’s
April 2019 election. All the posts that appeared on the contenders’ accounts at a point in time in each of the four pre-election
campaign weeks were analyzed to identify prominent issues. Social media and web content in Hebrew were also analysed over the same
period. The data was compared with 2,217 responses to questionnaires completed on the four dates. The questionnaires also surveyed
voters’ political orientations and the likelihood of their following the candidates’ accounts. The results revealed a significant
correlation between contenders’ and voters’ agendas. However, significant differences were identified in agendas between those
respondents who followed both leading candidates, those who followed a single candidate, and those who followed neither.
A CMOS-based neuromorphic device for seizure detection from LFP signals
Authors: Ronchini Margherita , Zamani Milad , Huynh Hai Au , Rezaeiyan Yasser , Panuccio Gabriella , Farkhani Hooman , Moradi Farshad 
Published: September 2021

Abstract
Recent research provides examples of neuromorphic systems applied to process biological signals or to interface biological tissues. Usually, in such contexts, the neuromorphic system is used for automatic anomaly detection. The automation of the long-term monitoring of biological signals holds promise for lightening the burden placed on clinicians. At the same time, the adoption of such devices potentially allows processing to be performed locally, without the need to transfer data to an external processor. In turn, on-site signal analysis makes closed-loop intervention feasible, to correct the source of the anomalies. So far, the common approach has been to deploy the network of spiking neurons either on multi-core neuromorphic platforms or on programmable units (field programmable gate array). However, if the aim is to develop wearable or even chronically implantable devices, it is imperative to move in the direction of embedded solutions, tailored and optimized for the specific application. To this end, the present study proposes a neuromorphic device implemented in CMOS technology for the detection of epileptic seizures (ictal events) from local field potential (LFP) signals. The LFP data have been acquired by a multi-electrode array in a slice of mouse hippocampus-cortex. The system includes an analog-to-event converter (AEC) encoding the recorded signals into trains of spikes, and a small spiking neural network (SNN) of 2 × 1 neurons with online biological-plausible learning. The AEC yields two spike-trains: UP spikes that account for the positive slope signal and DOWN spikes that correspond to the negative slope signal. The synapses among the input and output layers are plastic and follow the spike-timing-dependent plasticity rule. Early results show that the SNN module is able to detect ictal events with a delay of 64.98 ± 30.92 ms, consuming

<

50 pW. The layout of the entire system occupies 528 µm × 278 µm.
Noise generation in a bilayer ferromagnet-piezoelectric heterostructure at the converse magnetoelectric effect
Authors: Burdin Dmitry A , Ekonomov Nikolai A , Preobrazhenskii Vladimir L , Fetisov Yuri K 
Published: September 2021

Abstract
The paper describes first observation of parametric generation of noise in a composite multiferroic resonator. Resonator of a disk shape contains two mechanically coupled layers, one of which is the amorphous ferromagnet (FM) FeBSiC and the other is the piezoelectric (PE) lead zirconate titanate. DC magnetic field of 0–100 Oe is applied parallel to the plane of the resonator. Resonator is excited in the frequency range f = 2–10 kHz by a harmonic electric field with amplitude of up to 330 V cm−1 applied to the PE layer. Changes in the magnetization of the resonator caused by the converse magnetoelectric effect were recorded using an electromagnetic coil. With an increase in the excitation field to the threshold value, the parametric generation of harmonics and subharmonics with a discrete spectrum is observed, which then turns into a stochastic mode and a continuous spectrum of frequencies is generated. Noise density is hysterically dependent on the excitation field and non-monotonically depends on the dc magnetic field. Theory of parametric generation of the noise in a multiferroic resonator is developed, taking into account excitation of acoustic resonances and magnetoacoustic nonlinearity of the FM layer of the resonator. Theory, qualitatively describes the main characteristics of noise generation.
Medical consequences of radiation exposure of the bronchi—what can we learn from high-dose precision radiation therapy?
Authors: Lindberg Karin , Onjukka Eva 
Published: September 2021

Abstract
The bronchial tolerance to high doses of radiation is not fully understood. However, in the event of a radiological accident with unintended exposure of the central airways to high doses of radiation it would be important to be able to anticipate the clinical consequences given the magnitude of the absorbed dose to different parts of the bronchial tree. Stereotactic body radiation therapy (SBRT) is a radiation treatment technique involving a few large fractions of photon external-beam radiation delivered to a well-defined target in the body. Despite generally favourable results, with high local tumour control and low-toxicity profile, its utility for tumours located close to central thoracic structures has been questioned, considering reports of severe toxic symptoms such as haemoptysis (bleedings from the airways), bronchial necrosis, bronchial stenosis, fistulas and pneumonitis. In conjunction with patient- and tumour-related risk factors, recent studies have analysed the absorbed radiation dose to different thoracic structures of normal tissue to better understand their tolerance to these high doses per fraction. Although the specific mechanisms behind the toxicity are still partly unknown, dose to the proximal bronchial tree has been shown to correlate with high-grade radiation side effects. Still, there is no clear consensus on the tolerance dose of the different bronchial structures. Recent data indicate that a too high dose to a main bronchus may result in more severe clinical side effects as compared to a smaller sized bronchus. This review analyses the current knowledge on the clinical consequences of bronchial exposure to high dose hypofractionated radiation delivered with the SBRT technique, and the tolerance doses of the bronchi. It presents the current literature regarding types of high-grade clinical side effects, data on dose response and comments on other risk factors for high-grade toxic effects.
Decommissioning procedure and induced activation levels, calculations and measurements in an 18 MeV medical cyclotron
Authors: Calandrino Riccardo , Manenti Simone , Groppi Flavia , Broggi Francesco , Bergamaschi Carlo , Ferrari Andrea , Manenti Simona , Nizzi Massimiliano , Loria Alessandro , del Vecchio Antonella 
Published: September 2021

Abstract
The present article describes the decommissioning of a self-shielded 18 MeV medical cyclotron IBA Cyclone 18/9 after 14 years of operation. A Monte Carlo simulation of the possible nuclear reactions was performed in order to plan the decommissioning activities. During the cyclotron dismantling, the activities of the cyclotron components, concrete wall and floor samples were measured. Residual activities were analysed by means of an HPGe detector and liquid scintillation counting, and compared with simulation data. Dosimetry of the staff involved in the decommissioning procedure was monitored by individual TL dosimeters and/or digital dosimeter. The cyclotron component analysis confirmed the presence of gamma and pure beta emitters, 22Na, 54Mn, 60Co, 65Zn, 207Bi, 55Fe, 63Ni at different values of specific activity, depending on the positioning of the sample point and on the alloy of the sampled part. In these components the presence of gamma and pure beta emitters was measured 5 years after the shutdown at levels far above clearance limits as defined by the ‘Recommended radiological protection criteria for the recycling of metals from the dismantling of nuclear installations’ (RP89) guidelines. The simulation, carried out by FLUKA Code (version 2020.0.5) on the cyclotron components, provided good agreement with measurements, with a maximum discrepancy of the same order as the uncertainties. Four engineers of the cyclotron maintenance staff were involved in the dismounting of the hottest components and rigging of the cyclotron in the deposit 6 months after shutdown and two engineers were involved during the drilling phase 3.5 years after shutdown. The measured dose from external exposure of the involved staff was lower than 100 μSv person−1 during the first phase and lower than 20 μSv person−1 during the final drilling phase. Measured doses from intake were negligible. In conclusion, the decommissioning of the 18 MeV cyclotron does not represent a risk for the involved staff, but, due to the presence of long-lived radioisotopes, the cyclotron components are to be treated as low level radioactive waste, and stored in an authorised storage area for at least 25 years after shutdown.
Religion
Authors: Harris James A. 
Published: September 2021

Abstract
‘Religion' discusses Hume’s various treatments of religion, particularly in the essay ‘Of Miracles’, Dialogues concerning Natural Religion, and ‘The Natural History of Religion’. Hume's earlier writings show some interesting implications for religion, including A Treatise of Human Nature and the essay ‘Of National Characters’. Looking at ‘Of Miracles’ shows that Hume’s theme was not the possibility of miracles as such, but rather the rational grounds of belief in reports of miracles. Considering the Dialogues emphasizes the distinction between scepticism and atheism. Meanwhile, ‘Natural History’ emphasizes Hume’s interest in the dangerous moral consequences of monotheism. What is the future for religion? Perhaps Hume was unlikely to have supposed that his writings would do anything to reduce religion’s hold on the vast majority of human beings.
Prevalence of malnutrition risk among older French adults with culinary dependence
Authors: Van Wymelbeke-Delannoy Virginie , Maître Isabelle , Salle Agnès , Lesourd Bruno , Bailly Nathalie , Sulmont-Rossé Claire 
Published: September 2021

Abstract

Objective
The term ‘culinary dependence’ denotes a situation in which someone delegates all or part of their daily meal-related activities to a third party. The present study aimed to explore nutritional risk among older people (≥65 years) with culinary dependence.

Method
The first survey included 559 people either living at home without help, with help unrelated to food activities, with help related to food activities or living in nursing home. The second survey included 319 people with food help provided by a caregiver, by meals-on-wheels or by a nursing home. Nutritional status was assessed with the Mini-Nutritional Assessment. Sociological background and wellness variables (health, cognitive and mental status) were collected.

Results
The first survey found a strong association between culinary dependence and nutritional risk. About half of the people who delegated their food-related activities were malnourished or at risk of malnutrition compared with only 4% for people with no help and 12% for people with help unrelated to food activity. According to the second survey, this prevalence varied slightly depending on who the tasks were delegated to (46% for those who had the support of a caregiver; 60% for those who used a meals-on-wheels service; 69% for those living in nursing home). According to multivariate analyses, dependence categories, depressive symptoms and cognitive status were identified as independent determinants of malnutrition.

Conclusion
Without inferring a causal relationship between dependence and malnutrition, there is a strong need for care structures to take into account the issue of malnutrition when developing services targeting older people.
Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
Authors: Khoury Samar , Parisien Marc , Thompson Scott J , Vachon-Presseau Etienne , Roy Mathieu , Martinsen Amy E , Winsvold Bendik S ,   HUNT All-In Pain, Skogholt Anne Heidi , Brumpton Ben , Willer Cristen J , Fors Egil Andreas , Heuch Ingrid , Nielsen Jonas Bille , Storheim Kjersti , Hagen Knut , Nilsen Kristian Bernhard , Hveem Kristian , Fritsche Lars , Thomas Laurent F , Pedersen Linda M , Gabrielsen Maiken E , Johnsen Marianne Bakke , Lie Marie Udnesseter , Holmen Oddgeir , Børte Sigrid , Stensland Synne Øien , Zhou Wei , Mundal Ingunn P , Zwart John-Anker , Kania Artur , Mogil Jeffrey S , Diatchenko Luda 
Published: September 2021

Abstract
Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions. Whether chronic overlapping pain conditions represent a distinct pathophysiology from the occurrence of pain at only one site is unknown. Using genome-wide approaches, we compared genetic determinants of chronic single-site versus multisite pain in the UK Biobank. We found that different genetic signals underlie chronic single-site and multisite pain with much stronger genetic contributions for the latter. Among 23 loci associated with multisite pain, nine loci replicated in the HUNT cohort, with the DCC netrin 1 receptor (DCC) as the top gene. Functional genomics identified axonogenesis in brain tissues as the major contributing pathway to chronic multisite pain. Finally, multimodal structural brain imaging analysis showed that DCC is most strongly expressed in subcortical limbic regions and is associated with alterations in the uncinate fasciculus microstructure, suggesting that DCC-dependent axonogenesis may contribute to chronic overlapping pain conditions via corticolimbic circuits.
High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia
Authors: Ebrahimi-Fakhari Darius , Alecu Julian E , Brechmann Barbara , Ziegler Marvin , Eberhardt Kathrin , Jumo Hellen , D’Amore Angelica , Habibzadeh Parham , Faghihi Mohammad Ali , De Bleecker Jan L , Vuillaumier-Barrot Sandrine , Auvin Stéphane , Santorelli Filippo M , Neuser Sonja , Popp Bernt , Yang Edward , Barrett Lee , Davies Alexandra K , Saffari Afshin , Hirst Jennifer , Sahin Mustafa 
Published: September 2021

Abstract
Adaptor protein complex 4-associated hereditary spastic paraplegia is caused by biallelic loss-of-function variants in AP4B1, AP4M1, AP4E1 or AP4S1, which constitute the four subunits of this obligate complex. While the diagnosis of adaptor protein complex 4-associated hereditary spastic paraplegia relies on molecular testing, the interpretation of novel missense variants remains challenging. Here, we address this diagnostic gap by using patient-derived fibroblasts to establish a functional assay that measures the subcellular localization of ATG9A, a transmembrane protein that is sorted by adaptor protein complex 4. Using automated high-throughput microscopy, we determine the ratio of the ATG9A fluorescence in the trans-Golgi-network versus cytoplasm and ascertain that this metric meets standards for screening assays (Z′-factor robust &gt;0.3, strictly standardized mean difference &gt;3). The ‘ATG9A ratio’ is increased in fibroblasts of 18 well-characterized adaptor protein complex 4-associated hereditary spastic paraplegia patients [mean: 1.54 ± 0.13 versus 1.21 ± 0.05 (standard deviation) in controls] and receiver-operating characteristic analysis demonstrates robust diagnostic power (area under the curve: 0.85, 95% confidence interval: 0.849–0.852). Using fibroblasts from two individuals with atypical clinical features and novel biallelic missense variants of unknown significance in AP4B1, we show that our assay can reliably detect adaptor protein complex 4 function. Our findings establish the ‘ATG9A ratio’ as a diagnostic marker of adaptor protein complex 4-associated hereditary spastic paraplegia.
PET Metabolic Imaging of Time-Dependent Reorganization of Olfactory Cued Fear Memory Networks in Rats
Authors: Mouly Anne-Marie , Bouillot Caroline , Costes Nicolas , Zimmer Luc , Ravel Nadine , Litaudon Philippe 
Published: September 2021

Abstract
Memory consolidation involves reorganization at both the synaptic and system levels. The latter involves gradual reorganization of the brain regions that support memory and has been mostly highlighted using hippocampal-dependent tasks. The standard memory consolidation model posits that the hippocampus becomes gradually less important over time in favor of neocortical regions. In contrast, this reorganization of circuits in amygdala-dependent tasks has been less investigated. Moreover, this question has been addressed using primarily lesion or cellular imaging approaches thus precluding the comparison of recent and remote memory networks in the same animals. To overcome this limitation, we used microPET imaging to characterize, in the same animals, the networks activated during the recall of a recent versus remote memory in an olfactory cued fear conditioning paradigm. The data highlighted the drastic difference between the extents of the two networks. Indeed, although the recall of a recent odor fear memory activates a large network of structures spanning from the prefrontal cortex to the cerebellum, significant activations during remote memory retrieval are limited to the piriform cortex. These results strongly support the view that amygdala-dependent memories also undergo system-level reorganization, and that sensory cortical areas might participate in the long-term storage of emotional memories.