bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial
Authors: Amanat Man , Majmaa Anahita , Zarrabi Morteza , Nouri Masoumeh , Akbari Masood Ghahvechi , Moaiedi Ali Reza , Ghaemi Omid , Zamani Fatemeh , Najafi Sharif , Badv Reza Shervin , Vosough Massoud , Hamidieh Amir Ali , Salehi Mona , Montazerlotfelahi Hadi , Tavasoli Ali Reza , Heidari Morteza , Mohebi Hossein , Fatemi Ali , Garakani Amir , Ashrafi Mahmoud Reza 
Published: August 2021

Abstract
Background
This study assessed the safety and efficacy of intrathecal injection of umbilical cord tissue mesenchymal stem cells (UCT-MSC) in individuals with cerebral palsy (CP). The diffusion tensor imaging (DTI) was performed to evaluate the alterations in white-matter integrity.

Methods
Participants (4–14 years old) with spastic CP were assigned in 1:1 ratio to receive either UCT-MSC or sham procedure. Single-dose (2 × 107) cells were administered in the experimental group. Small needle pricks to the lower back were performed in the sham-control arm. All individuals were sedated to prevent awareness. The primary endpoints were the mean changes in gross motor function measure (GMFM)-66 from baseline to 12 months after procedures. The mean changes in the modified Ashworth scale (MAS), pediatric evaluation of disability inventory (PEDI), and CP quality of life (CP-QoL) were also assessed. Secondary endpoints were the mean changes in fractional anisotropy (FA) and mean diffusivity (MD) of corticospinal tract (CST) and posterior thalamic radiation (PTR).

Results
There were 36 participants in each group. The mean GMFM-66 scores after 12 months of intervention were significantly higher in the UCT-MSC group compared to baseline (10.65; 95%CI 5.39, 15.91) and control (β 8.07; 95%CI 1.62, 14.52; Cohen’s d 0.92). The increase was also seen in total PEDI scores (vs baseline 8.53; 95%CI 4.98, 12.08; vs control: β 6.87; 95%CI 1.52, 12.21; Cohen’s d 0.70). The mean change in MAS scores after 12 months of cell injection reduced compared to baseline (−1.0; 95%CI −1.31, −0.69) and control (β −0.72; 95%CI −1.18, −0.26; Cohen’s d 0.76). Regarding CP-QoL, mean changes in domains including friends and family, participation in activities, and communication were higher than the control group with a large effect size. The DTI analysis in the experimental group showed that mean FA increased (CST 0.032; 95%CI 0.02, 0.03. PTR 0.024; 95%CI 0.020, 0.028) and MD decreased (CST −0.035 × 10-3; 95%CI −0.04 × 10-3, −0.02 × 10-3. PTR −0.045 × 10-3; 95%CI −0.05 × 10-3, −0.03 × 10-3); compared to baseline. The mean changes were significantly higher than the control group.

Conclusions
The UCT-MSC transplantation was safe and may improve the clinical and imaging outcomes.

Trial registration
The study was registered with ClinicalTrials.gov (NCT03795974).
Biomimetic nerve guidance conduit containing engineered exosomes of adipose-derived stem cells promotes peripheral nerve regeneration
Authors: Yang Zheng , Yang Yang , Xu Yichi , Jiang Weiqian , Shao Yan , Xing Jiahua , Chen Youbai , Han Yan 
Published: August 2021

Abstract
Background
Efficient and stable delivery of neurotrophic factors (NTFs) is crucial to provide suitable microenvironment for peripheral nerve regeneration. Neurotrophin-3 (NT-3) is an important NTF during peripheral nerve regeneration which is scarce in the first few weeks of nerve defect. Exosomes are nanovesicles and have been served as promising candidate for biocarrier. In this work, NT-3 mRNA was encapsulated in adipose-derived stem cell (ADSC)-derived exosomes (ExoNT-3). These engineered exosomes were applied as NT-3 mRNA carrier and then were loaded in nerve guidance conduit (ExoNT-3-NGC) to bridge rat sciatic nerve defect.

Method
NT-3 mRNA was encapsulated in exosomes by forcedly expression of NT-3 mRNA in the donor ADSCs. ExoNT-3 were co-cultured with SCs in vitro; after 24 h of culture, the efficiency of NT-3 mRNA delivery was evaluated by qPCR, western blotting and ELISA. Then, ExoNT-3 were loaded in alginate hydrogel to construct the nerve guidance conduits (ExoNT-3-NGC). ExoNT-3-NGC were implanted in vivo to reconstruct 10 mm rat sciatic nerve defect. The expression of NT-3 was measured 2 weeks after the implantation operation. The sciatic nerve functional index (SFI) was examined at 2 and 8 weeks after the operation. Moreover, the therapeutic effect of ExoNT-3-NGC was also evaluated by morphology assay, immunofluorescence staining of regenerated nerves, function evaluation of gastrocnemius muscles after 8 weeks of implantation.

Results
The engineered exosomes could deliver NT-3 mRNA to the recipient cells efficiently and translated into functional protein. The constructed NGC could realize stable release of exosomes at least for 2 weeks. After NGC implantation in vivo, ExoNT-3-NGC group significantly promote nerve regeneration and improve the function recovery of gastrocnemius muscles compared with control exosomes (Exoempty-NGC) group.

Conclusion
In this work, NGC was constructed to allow exosome-mediated NT-3 mRNA delivery. After ExoNT-3-NGC implantation in vivo, the level of NT-3 could restore which enhance the nerve regeneration. Our study provide a potential approach to improve nerve regeneration.
Influence mechanism of running sportswear fatigue based on BP neural network
Authors: Liu Xiaoli , Li Zhibin 
Published: August 2021

AbstractThe fatigue of running sportswear is reflected in the fatigue caused by the tightness of the tights on the skin surface of the limbs, trunk, and other parts during long-term running sports. However, the current research on the fatigue of running sportswear is not deep enough. Therefore, the purpose of this study is to study the mechanism of the fatigue of running sportswear based on BP neural network. This article first takes sportswear as the starting point and uses the surface myoelectricity index as a physiological quantity as a means to combine clothing with sports medicine and sports physiology, breaking the traditional shackles of subjective assessment of fatigue, and giving play to the advantages of interdisciplinary to expand the new direction of the apparel industry and, secondly, use muscle fatigue evaluation method to analyze the muscles of the lower leg under the pressure of sportswear to analyze the strength of the EMG signal and the number of participating sports units and the frequency of discharge synchronization. Experimental data shows that the AUC is 0.756 when wearing sports tights, the sensitivity and specificity are 72% and 19%, and the accuracy is 65%. The experimental results show that clothing pressure affects the fatigue of running sportswear based on BP neural network.
Retention in opioid agonist treatment: a rapid review and meta-analysis comparing observational studies and randomized controlled trials
Authors: Klimas Jan , Hamilton Michee-Ana , Gorfinkel Lauren , Adam Ahmed , Cullen Walter , Wood Evan 
Published: August 2021

Abstract
Background
Although oral opioid agonist therapies (OATs), buprenorphine and methadone, are effective first-line treatments, OAT remains largely underutilized due to low retention rates and wide variation across programs. This rapid review therefore sought to summarize the retention rates reported by randomized controlled trials (RCTs) and controlled observational study designs that compared methadone to buprenorphine (or buprenorphine-naloxone).

Methods
We searched four electronic databases (EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL, up to April 2018) for RCTs and controlled observational studies that compared oral fixed-dose methadone to buprenorphine versus methadone (or buprenorphine-naloxone). Data were extracted separately for two different definitions of retention in treatment: (1) length of time retained in the study and (2) presence on the final day of a study. Separate random effects meta-analyses were performed for RCTs and controlled observational studies. Data from controlled observational studies where retention was measured as the length of time retained in the study were not amenable to meta-analysis.

Results
Among 7603 studies reviewed, 10 RCTs and 3 observational studies met inclusion criteria (n = 5065) and compared fixed-dose oral buprenorphine with methadone. Across studies, the average retention rate was highly variable (RCTs: buprenorphine 20.0–82.5% and methadone 30.7–83.8%; observational studies: buprenorphine 20.2–78.3% and methadone 48.3–74.8%). For time period retained in the study, we observed no significant difference in treatment retention for buprenorphine versus methadone in RCTs (standardized mean difference [SMD] =  − 0.07; 95% CI − 0.35–0.21, p = 0.63; quality of evidence: low). For presence on the final study day, we observed no significant difference between buprenorphine and methadone treatment retention in RCTs (risk ratio [RR] = 0.89; 95% CI 0.73–1.08, p = 0.24; quality of evidence: low) and controlled observational studies (RR = 0.75; 95% CI 0.36–1.58, p = 0.45).

Conclusion
Meta-analysis of existing RCTs suggests retention in oral fixed-dose opioid agonist therapy with methadone appears to be generally equal to buprenorphine (or buprenorphine-naloxone), with wide variation across studies. Similarly, a meta-analysis of three controlled observational studies indicated no difference in treatment retention although there was significant heterogeneity among the included studies. The length of follow-up did not appear to affect the retention rate.

Systematic review registration
PROSPERO CRD42018104452.
Correlation between antibiotic consumption and the incidence of healthcare facility-onset Clostridioides difficile infection: a retrospective chart review and analysis
Authors: Yun Ji Hyun , Park Ga Eun , Ki Hyun Kyun 
Published: August 2021

Abstract
Background
Healthcare facility-onset Clostridioides difficile infection is the leading cause of antibiotic-associated diarrhea, and is associated with morbidity and mortality. The use of antibiotics is an important risk factor for healthcare facility-onset C. difficile infection. We evaluated the correlation between the incidence of healthcare facility-onset C. difficile infection and antibiotic consumption, according to antibiotic class.

Methods
Patients with healthcare facility-onset C. difficile infection from January 2017 to December 2018 at Konkuk University Medical Center (a tertiary medical center) were included. We evaluated changes in the incidence of healthcare facility-onset C. difficile infection and antibiotic consumption. The correlation between the incidence of healthcare facility-onset C. difficile infection and antibiotic consumption was evaluated two ways: without a time interval and with 1-month interval matching.

Results
A total of 446 episodes of healthcare facility-onset C. difficile infection occurred during the study period. The incidence of healthcare facility-onset C. difficile infection was 9.3 episodes per 10,000 patient-days, and increased significantly. We observed an increase in the consumption of β-lactam/β-lactamase inhibitors, and a decrease in the consumption of other classes of antibiotics, with a significant decrease in the consumption of fluoroquinolones, glycopeptides, and clindamycin (P = 0.01, P < 0.001, and P = 0.001, respectively). The consumption of β-lactam/β-lactamase inhibitors was independently correlated with the incidence of healthcare facility-onset C. difficile infection in the analysis without a time interval. When the analysis was conducted with 1-month interval matching, glycopeptide consumption was independently associated with the incidence of healthcare facility-onset C. difficile infection.

Conclusions
Despite the reduction in fluoroquinolone and clindamycin consumption, the incidence of healthcare facility-onset C. difficile infection increased during the study period, and was correlated with increased consumption of β-lactam/β-lactamase inhibitors. Reduced consumption of specific antibiotics may be insufficient to reduce the incidence of healthcare facility-onset C. difficile infection.
Arterial spin labeling for presurgical localization of refractory frontal lobe epilepsy in children
Authors: Zhang Jia , Zhang Heng , Li Yang , Yuan Meng , Zhang Jinxiu , Luo Huan , Yao Zeshan , Gan Jing 
Published: August 2021

Abstract
Background
Epilepsy is one of the most common chronic neurological diseases. Despite the great variety and prevalence of antiepileptic drug treatments, one-third of epilepsies remain drug resistant. The frontal lobe is extensive, and frontal lobe seizures are difficult to locate, which increases the difficulty of the preoperative localization of the epileptogenic zone.

Case presentation
Two previously healthy girls with refractory frontal lobe epilepsy showed significant perfusion abnormalities in the right frontal lobe using the cerebral blood perfusion (CBF) quantitative analysis system. They became seizure-free after lesionectomy of the frontal lobe by ASL combined with electroencephalography (EEG) rapid localization. The histopathological diagnosis was focal cortical dysplasia (FCD) type IIa and IIb.

Conclusions
The positive outcome suggests that the combined use of ASL with EEG could be a beneficial option for the presurgical evaluation of pediatric epilepsy.
A note on the multiplicative fairness score in the NIJ recidivism forecasting challenge
Authors: Mohler George , Porter Michael D. 
Published: August 2021

Abstract
Background
The 2021 NIJ recidivism forecasting challenge asks participants to construct predictive models of recidivism while balancing false positive rates across groups of Black and white individuals through a multiplicative fairness score. We investigate the performance of several models for forecasting 1-year recidivism and optimizing the NIJ multiplicative fairness metric.

Methods
We consider standard linear and logistic regression, a penalized regression that optimizes a convex surrogate loss (that we show has an analytical solution), two post-processing techniques, linear regression with re-balanced data, a black-box general purpose optimizer applied directly to the NIJ metric and a gradient boosting machine learning approach.

Results
For the set of models investigated, we find that a simple heuristic of truncating scores at the decision threshold (thus predicting no recidivism across the data) yields as good or better NIJ fairness scores on held out data compared to other, more sophisticated approaches. We also find that when the cutoff is further away from the base rate of recidivism, as is the case in the competition where the base rate is 0.29 and the cutoff is 0.5, then simply optimizing the mean square error gives nearly optimal NIJ fairness metric solutions.

Conclusions
The multiplicative metric in the 2021 NIJ recidivism forecasting competition encourages solutions that simply optimize MSE and/or use truncation, therefore yielding trivial solutions that forecast no one will recidivate.
DSM-5 personality trait facets amongst child molesters: an exploratory comparison with other types of offenders
Authors: Ferretti Fabio , Carabellese Felice , Catanesi Roberto , Coluccia Anna , Ferracuti Stefano , Schimmenti Adriano , Caretti Vincenzo , Lorenzi Lore , Gualtieri Giacomo , Carabellese Fulvio , Pozza Andrea 
Published: August 2021

Abstract
Background
DSM-5 provided a dimensional model of personality disorders which may be more clinically informative for the assessment and management of prisoners than a categorical one, as diagnoses of personality disorders alone cannot explain the type of violence. The role of DSM-5 personality facets is however understudied in child molesters, and no study compared these clinical features between individuals who have committed sex crime against children and those who have committed other types of crime. The present study compared DSM-5 personality trait facets between prisoners who had committed sex crime against children, prisoners who had committed property crime (i.e., robbery, fraud) and those who had committed crime against the person (i.e., homicide, assault or violence not implying a sexual element). A further aim was to explore which facets were associated with sex crime against children as compared with the other types of crime, controlling for socio-demographics (age, gender), psychiatric comorbidity (presence of any psychiatric diagnoses) and general psychopathy traits.

Methods
One hundred sixty-seven prisoners participated (91 had committed sex crime against children, 25 property crime, and 51 committed a crime against the person) and completed the Personality Inventory for the DSM-5 and the Psychopathy Checklist-Revised.

Results
Prisoners who had committed sex crime against children reported higher Restricted Affectivity traits than those who had committed property crime and crime against the person and higher Irresponsibility traits than those who had committed property crime. The results of a multinomial logistic regression analysis showed that on the one hand being a man, having a higher age, and the presence of a psychiatric comorbidity were more likely to be related to sex crime than property crime, on the other hand higher Irresponsibility personality traits, being a man, and the presence of a psychiatric comorbidity were more likely to be related to sex crime against children than crime against the person.

Conclusions
The Irresponsibility facet might be specific to child molesters and can differentiate this group from offenders who have committed other crime types. This facet might be considered a key target of a tailored assessment and treatment planning during clinical practice with child molesters.
Evaluation of deep geothermal exploration drillings in the crystalline basement of the Fennoscandian Shield Border Zone in south Sweden
Authors: Rosberg Jan-Erik , Erlström Mikael 
Published: August 2021

AbstractThe 3.1- and 3.7-km-deep FFC-1 and DGE-1 geothermal explorations wells drilled into the Precambrian crystalline basement on the southern margin of the Fennoscandian Shield are evaluated regarding experiences from drilling, geological conditions, and thermal properties. Both wells penetrate an approximately 2-km-thick succession of sedimentary strata before entering the crystalline basement, dominated by orthogneiss, metabasite and amphibolite of the (1.1–0.9 Ga) Eastern Interior Sveconorwegian Province. The upper c. 400 m of the basement is in FFC-1 severely fractured and water-bearing which disqualified the use of percussion air drilling and conventional rotary drilling was, therefore, performed for the rest of the borehole. The evaluation of the rotary drillings in FFC-1 and DGE-1 showed that the average bit life was very similar, 62 m and 68 m, respectively. Similarly, the average ROP varied between 2 and 4 m/h without any preferences regarding bit-type (PDC or TCI) or geology. A bottomhole temperature of 84.1 °C was measured in FFC-1 borehole with gradients varying between 17.4 and 23.5 °C/km for the main part of the borehole. The calculated heat flow varies between 51 and 66 mW/m2and the average heat production is 3.0 µW/m3. The basement in FFC-1 is, overall, depleted in uranium and thorium in comparison to DGE-1 where the heat productivity is overall higher with an average of 5.8 µW/m3. The spatial distribution of fractures was successfully mapped using borehole imaging logs in FFC-1 and shows a dominance of N–S oriented open fractures, a fracture frequency varying between 0.85 and 2.49 frac/m and a fracture volumetric density between 1.68 and 3.39 m2/m3. The evaluation of the two boreholes provides insight and new empirical data on the thermal properties and fracturing of the concealed crystalline basement in the Fennoscandian Shield Border Zone that, previously, had only been assessed by assumptions and modelling. The outcome of the drilling operation has also provided insight regarding the drilling performance in the basement and statistical data on various drill bits used. The knowledge gained is important in feasibility studies of deep geothermal projects in the crystalline basement in south Sweden.
Electroacupuncture suppresses glucose metabolism and GLUT-3 expression in medial prefrontal cortical in rats with neuropathic pain
Authors: Jiang Menghong , Chen Xiaomei , Zhang Liangping , Liu Weiting , Yu Xiangmei , Wang Zhifu , Zheng Meifeng 
Published: August 2021

AbstractBackgroundAccumulating evidence has demonstrated that the electroacupuncture (EA) stimulation could effectively alleviate neuropathic pain. The medial prefrontal cortex (mPFC) is a vital part of the cortical representation of pain in the brain, and its glucose metabolism is mostly affected in the progression of pain. However, the central mechanism of EA analgesia remains unclear.MethodsFifty-four male SD rats were equally randomized into sham surgery (Sham) group, chronic constriction injury (CCI) group and EA stimulation (EA) group. The CCI model, involving ligature of the right sciatic nerve, was established in all animals except the Sham group. EA stimulation was applied on the right side acupoints of Huantiao (GB30) and Yanglingquan (GB34) in the EA group. Paw withdrawal threshold (PWT) and paw thermal withdrawal latency (PWL) were measured. The18F-fluorodeoxyglucose positron emission tomography (FDG-PET) was used to evaluate glucose metabolism changes in the mPFC. The expression of glucose transporter 3 (GLUT-3) in the mPFC was determined by immune histochemistry and ELISA.ResultsComparing with CCI groups, EA treatment was obviously reversed CCI-induced mechanical allodynia (P < 0.01), thermal hyperalgesia (P < 0.01) and the increase of glucose metabolism in the left mPFC (P < 0.05). Furthermore, EA treatment significantly decreased the protein expression of GLUT-3 in the left mPFC (P < 0.01).ConclusionsOur results indicate that EA analgesia effect may be related to suppressing the glucose metabolism and GLUT-3 expression in the mPFC. This study could provide a potential insight into the central mechanisms involved in the analgesic effect of EA.
Robust unified Granger causality analysis: a normalized maximum likelihood form
Authors: Hu Zhenghui , Li Fei , Cheng Minjia , Shui Junhui , Tang Yituo , Lin Qiang 
Published: August 2021

AbstractUnified Granger causality analysis (uGCA) alters conventional two-stage Granger causality analysis into a unified code-length guided framework. We have presented several forms of uGCA methods to investigate causal connectivities, and different forms of uGCA have their own characteristics, which capable of approaching the ground truth networks well in their suitable contexts. In this paper, we considered comparing these several forms of uGCA in detail, then recommend a relatively more robust uGCA method among them, uGCA-NML, to reply to more general scenarios. Then, we clarified the distinguished advantages of uGCA-NML in a synthetic 6-node network. Moreover, uGCA-NML presented its good robustness in mental arithmetic experiments, which identified a stable similarity among causal networks under visual/auditory stimulus. Whereas, due to its commendable stability and accuracy, uGCA-NML will be a prior choice in this unified causal investigation paradigm.