bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats
Authors: Zheng Panpan , Kang Jiyu , Xing Entong , Zheng Bin , Wang Xueyao , Zhou Huacheng 
Published: August 2021

Background: Lung inflation with hydrogen is an effective method to protect donor lungs from lung ischemia-reperfusion injury (IRI). This study aimed to examine the effect of lung inflation with 3% hydrogen during the cold ischemia phase on pyroptosis in lung grafts of rats.Methods: Adult male Wistar rats were randomly divided into the sham group, the control group, the oxygen (O2) group, and the hydrogen (H2) group. The sham group underwent thoracotomy but no lung transplantation. In the control group, the donor lungs were deflated for 2 h. In the O2 and H2 groups, the donor lungs were inflated with 40% O2 + 60% N2 and 3% H2 + 40% O2 + 57% N2, respectively, at 10 ml/kg, and the gas was replaced every 20 min during the cold ischemia phase for 2 h. Two hours after orthotopic lung transplantation, the recipients were euthanized.Results: Compared with the control group, the O2 and H2 groups improved oxygenation indices, decreases the inflammatory response and oxidative stress, reduced lung injury, and improved pressure-volume (P-V) curves. H2 had a better protective effect than O2. Furthermore, the levels of the pyroptosis-related proteins selective nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), cysteinyl aspartate specific proteinase (caspase)-1 p20, and the N-terminal of gasdermin D (GSDMD-N) were decreased in the H2 group.Conclusion: Lung inflation with 3% hydrogen during the cold ischemia phase inhibited the inflammatory response, oxidative stress, and pyroptosis and improved the function of the graft. Inhibiting reactive oxygen species (ROS) production may be the main mechanism of the antipyroptotic effect of hydrogen.
Auricular Neuromodulation for Mass Vagus Nerve Stimulation: Insights From SOS COVID-19 a Multicentric, Randomized, Controlled, Double-Blind French Pilot Study
Authors: Rangon Claire-Marie , Barruet Régine , Mazouni Abdelmadjid , Le Cossec Chloé , Thevenin Sophie , Guillaume Jessica , Léguillier Teddy , Huysman Fabienne , Luis David 
Published: August 2021

Importance: An exacerbated inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is believed to be one of the major causes of the morbidity and mortality of the coronavirus disease 2019 (COVID-19). Neuromodulation therapy, based on vagus nerve stimulation, was recently hypothesized to control both the SARS-CoV-2 replication and the ensuing inflammation likely through the inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells pathway and could improve the clinical outcomes as an adjunct treatment. We proposed to test it by the stimulation of the auricular branch of the vagus nerve, i.e., auricular neuromodulation (AN), a non-invasive procedure through the insertion of semipermanent needles on the ears.Objective: The aim of this study was to assess the effect of AN on the clinical outcomes in patients affected by COVID-19.Design, Setting, and Participants: A multicenter, randomized, placebo-controlled, double-blind clinical trial included 31 patients with respiratory failure due to COVID-19 requiring hospitalization. Within 72 h after admission, patients received either AN (n = 14) or sham neuromodulation (SN, n = 15) in addition to the conventional treatments.Main Outcome and Measures: The primary endpoint of the study was the rate of a clinical benefit conferred by AN at Day 14 (D14) as assessed by a 7-point Clinical Progression Scale. The secondary endpoint of the study was the impact of AN on the rate of transfer to the intensive care unit (ICU) and on the survival rate at D14.Results: The AN procedure was well-tolerated without any reported side effects but with no significant improvement for the measures of both primary (p &gt; 0.3) and secondary (p &gt; 0.05) endpoints at the interim analysis. None of the AN-treated patients died but one in the SN group did (81 years). Two AN-treated patients (73 and 79 years, respectively) and one SN-treated patient (59 years) were transferred to ICU. Remarkably, AN-treated patients were older with more representation by males than in the SN arm (i.e., the median age of 75 vs. 65 years, 79% male vs. 47%).Conclusion: The AN procedure, which was used within 72 h after the admission of patients with COVID-19, was safe and could be successfully implemented during the first two waves of COVID-19 in France. Nevertheless, AN did not significantly improve the outcome of the patients in our small preliminary study. It is pertinent to explore further to validate AN as the non-invasive mass vagal stimulation solution for the forthcoming pandemics.Clinical Trial Registration: [https://clinicaltrials.gov/], identifier [NCT04341415].
Investigating Links Between Fear of COVID-19, Neuroticism, Social Networks Use Disorder, and Smartphone Use Disorder Tendencies
Authors: Montag Christian , Sindermann Cornelia , Rozgonjuk Dmitri , Yang Shixin , Elhai Jon D. , Yang Haibo 
Published: August 2021

The present study investigates links between fear of COVID-19, the personality trait of neuroticism, social networks use disorder, and smartphone use disorder (SNUD and SmUD, respectively) tendencies. In an online survey, N = 932 participants recruited at a Chinese University (237 males and 695 females) completed self-reports on fear of COVID-19, neuroticism (and other personality traits from the Big Five Inventory-44), the Bergen Social Media Addiction Scale (assessing tendencies toward SNUD), and the Smartphone Addiction Scale short version—assessing individual differences in tendencies toward SmUD.Our findings showed that all variables of main interest were positively correlated with each other. A mediation model suggested that SNUD (in parts) mediated the association between fear of COVID-19 and SmUD. Although neuroticism was robustly correlated with all mentioned variables, no moderation effect could be observed on the investigated fear-of-COVID-19-SNUD-link.The findings of this work provide further evidence that the smartphone itself is only a device giving individuals access to software applications, which might be excessively used. Beyond that, the present data indicate neuroticism to be a risk factor with respect to fear of COVID-19, SNUD, and SmUD, although the study is limited by its cross-sectional study design.
Impact of Perceived Severity of COVID-19 (SARS-COV-2) on Mental Health of University Students of Pakistan: The Mediating Role of Muslim Religiosity
Authors: Saleem Muhammad , Bakar Abou , Durrani Areeha Khan , Manzoor Zubair 
Published: August 2021

Background: Perceived severity of COVID-19 (SARS-COV-2) is known to be associated with mental health of people in general and health professionals in particular in Western societies. However, its association with the mental health of students in Pakistan, which is predominantly a Muslim society, remains unclear so far. Moreover, the role of Muslim religiosity for such an association has not yet been investigated. We aimed to examine the association and report findings on the impact of perceived severity on mental health with a sample of students from all five provinces of Pakistan.Methods: We did a cross-sectional online survey from 1,525 Pakistani students in March 2020 using standardized measurement tools. We then determined the prevalence of perceived severity among students and its impact on their mental health. The strength of associations between these variables was estimated using generalized linear models, with appropriate distribution and link functions. Structural equation modeling through SmartPLS (3.0) software was utilized to analyze the results.Findings: The perceived severity of COVID-19 is significantly associated with mental health of Pakistani students, whereas Muslim religiosity is a strong mediator between perceived severity and mental health of Pakistani students.Conclusions: Though the perceived severity of COVID-19 is associated with mental health, this relationship can be better explained by the role of Muslim religiosity. When tested individually, the perceived severity accounted for only 18% variance in mental health that increased up to 57% by the mediating role of Muslim religiosity. This difference clearly indicates the mediating role of Muslim religiosity in the association between perceived severity and mental health for Pakistani students.
Developing a Tool to Measure Person-Centered Care in Service Planning
Authors: Stanhope Victoria , Baslock Daniel , Tondora Janis , Jessell Lauren , Ross Abigail M. , Marcus Steven C. 
Published: August 2021

Background: Delivering person-centered care is a key component of health care reform. Despite widespread endorsement, medical and behavioral health settings struggle to specify and measure person-centered care objectively. This study presents the validity and reliability of the Person-Centered Care Planning Assessment Measure (PCCP-AM), an objective measure of the extent to which service planning is person-centered.Methods: Based upon the recovery-oriented practice of person-centered care planning, the 10-item PCCP-AM tool rates service plans on the inclusion of service user strengths, personal life goals, natural supports, self-directed actions and the promotion of community integration. As part of a large randomized controlled trial of person-centered care planning, service plans completed by community mental health clinic providers were rated using the PCCP-AM. Reliability was tested by calculating inter-rater reliability across 168 plans and internal consistency across 798 plans. To test concurrent validity, PCCP-AM scores for 84 plans were compared to expert rater scores on a separate instrument.Results: Interrater reliability for each of the 10 PCCP-AM items as measured by Kendall's W ranged from W = 0.77 to W = 0.89 and percent of scores within ± 1 point of each other ranged from 85.7 to 100%. Overall internal consistency as measured by Cronbach's alpha across 798 plans was α = 0.72. Concurrent validity as measured by Kendall's W ranged from W = 0.55 to W = 0.74 and percent of item scores within ± 1 point of expert rater scores ranged from 73.8 to 86.8%.Conclusions: Findings demonstrated that the 10-item PCCP-AM was a valid and reliable objective measure of person-centered care. Using the service plan as an indicator of multiple domains of person-centered care, the measure provides a valuable tool to inform clinical supervision and quality improvement across programs. More psychometric testing is needed to strengthen the measure for research purposes.
COVID-19 Vaccination Acceptance Among Healthcare Workers and Non-healthcare Workers in China: A Survey
Authors: Wang Ming-Wei , Wen Wen , Wang Nan , Zhou Meng-Yun , Wang Chun-yi , Ni Jie , Jiang Jing-jie , Zhang Xing-wei , Feng Zhan-Hui , Cheng Yong-Ran 
Published: August 2021

Background: The coronavirus pneumonia is still spreading around the world. Much progress has been made in vaccine development, and vaccination will become an inevitable trend in the fight against this pandemic. However, the public acceptance of COVID-19 vaccination still remains uncertain.Methods: An anonymous questionnaire was used in Wen Juan Xing survey platform. All the respondents were divided into healthcare workers and non-healthcare workers. Multinomial logistic regression analyses were performed to identify the key sociodemographic, cognitive, and attitude associations among the samples of healthcare workers and non-healthcare workers.Results: A total of 2,580 respondents completed the questionnaire, including 1,329 healthcare workers and 1,251 non-healthcare workers. This study showed that 76.98% of healthcare workers accepted the COVID-19 vaccine, 18.28% workers were hesitant, and 4.74% workers were resistant. Among the non-healthcare workers, 56.19% workers received the COVID-19 vaccine, 37.57% workers were hesitant, and 6.24% workers were resistant. Among the healthcare workers, compared with vaccine recipients, vaccine-hesitant individuals were more likely to be female (AOR = 1.52, 95% CI: 1.12–2.07); vaccine-resistant individuals were more likely to live in the suburbs (AOR = 2.81, 95% CI: 1.44–3.99) with an income of 10,000 RMB or greater (AOR = 2.00, 95% CI: 1.03–3.90). Among the non-healthcare workers, vaccine-hesitant individuals were more likely to be female (AOR = 1.66, 95% CI: 1.31–2.11); vaccine-resistant individuals were also more likely to be female (AOR = 1.87, 95% CI: 1.16–3.02) and older than 65 years (AOR = 4.96, 95% CI: 1.40–7.62). There are great differences between healthcare workers and non-healthcare workers in their cognition and attitude toward vaccines.Conclusions: Our study shows that healthcare workers are more willing to be vaccinated than non-healthcare workers. Current vaccine safety issues continue to be a major factor affecting public acceptance, and to expand vaccine coverage in response to the COVID-19 pandemic, appropriate vaccination strategies and immunization programs are essential, especially for non-healthcare workers.
Influence of Martian Radiation-like Conditions on the Growth of Secale cereale and Lepidium sativum
Authors: Tack N. , Wamelink G.W.W. , Denkova A.G. , Schouwenburg M. , Hilhorst H. , Wolterbeek H.T. , Goedhart P.W. 
Published: August 2021

The Martian surface is constantly exposed to a high dose of cosmic radiation consisting of highly energetic particles and multiple types of ionizing radiation. The dose can increase temporarily by a factor of 50 through the occurrence of highly energetic solar flares. This may affect crop growth in greenhouses on the Martian surface possibly making settlement of humans more complicated. Shielding crops from radiation might be done at the expense of lighting efficiency. However, the most energy-efficient cultivation may be achieved through the use of natural daylight with the addition of LED lights. The goal of our research was to investigate whether Martian radiation, both the constant and the solar flares events, affects plant growth of two crop species, rye and garden cress. The levels of radiation received on the surface of Mars, simulated with an equivalent dose of 60Co γ-photons, had a significant negative effect on the growth of the two crop species. Although germination percentages were not affected by radiation, biomass growth was significantly decreased by 32% for cress and 48% for rye during the first 4 weeks after germination. Part of the biomass differences may be due to differences in temperature between radiation and control treatment, however it cannot explain the whole difference between the treatment and control. Coloring of leaves, necrosis and brown parts, was observed as well. Temporary increases in ionizing radiation dose at different development stages of the plants did not significantly influence the final dry weight of the crops.
Perancangan Sistem Informasi Manajemen Surat (SIMURAT) Pada AKAKOM Stephen Jambi
Authors: Husaein Ahmad 
Published: August 2021

Setiap organisasi memiliki keinginan untuk bertumbuh. Organisasi yang ingin bertumbuh harus memiliki sistem kerja dengan beragam aktifitas yang saling bekerja sama antara bagian yang satu dengan bagian lainnya untuk mencapai suatu tujuan yang ditetapkan. Banyak organisasi yang kurang memperhatikan keberadaan arsip surat masuk dan surat keluar yang jika tidak dikelola dengan baik dapat mengganggu kegiatan organisasi tersebut. Pengelolaan surat masuk dan surat keluar pada AKAKOM Stephen Jambi dilakukan secara konvensional sehingga menyebabkan arsip tercecer, rusak bahkan hilang. Pemanfaatan teknologi informasi dapat mengatasi masalah manajemen surat, sehingga pengarsipan surat masuk dan keluar serta disposisi surat dapat berjalan dengan cepat, tepat dan akurat. Pengembangan sistem informasi manajemen surat (SIMURAT) ini menggunakan metode waterfall dimana proses dilakukan secara berurutan atau secara linier sesuai tahapan dalam metode tersebut. Penelitian ini menghasilkan perangkat lunak berbasis web yang dapat mengatasi permasalahan dalam manajemen surat masuk dan surat keluar.
Evaluasi Proses Bisnis Akademik STIKOM Dinamika Bangsa Melalui Pendekatan Business Process Improvement
Authors: Sunoto Akwan 
Published: August 2021

STIKOM Dinamika Bangsa adalah satu perguruan tinggi bidang ilmu komputer namun belum semua aktivitas dalam proses bisnis akademiknya didukung dengan penggunaan teknologi informasi sehingga proses bisnisnya tidak berjalan optimal. Ada beberapa kendala muncul dalam proses bisnis akademiknya seperti panjangnya proses yang dilalui, aktivitas yang berbelit serta lamanya aktivitas diproses sehingga aktivitas tidak berjalan efektif. Oleh karena itu proses bisnis akademik ini perlu dianalisis dan dievaluasi. Dalam penelitian ini evaluasi dilakukan melalui pendekatan Business Process Improvement (BPI) sedangkan pemodelan proses bisnisnya menggunakan Business Process Modelling Notation (BPMN). Kegiatan penelitian ini menghasilkan pemodelan serta rekomendasi-rekomendasi perbaikan terhadap aktivitas-aktivitas yang terdapat didalam masing-masing proses bisnis sehingga efektivitas dan efisiensi dari proses bisnis dapat ditingkatkan.
Penerapan Algoritma Fp-Growth Dalam Menentukan Perilaku Konsumen Ghania Mart Muara Bulian
Authors: Anas Azwar 
Published: August 2021

Ghania Mart merupakan salah satu minimarket yang beroperasi di Muara Bulian, tepatnya di Jl. Prof. Dr. Sri Sudewi atau depan Rumah Sakit Umum Daerah Haji Abdoel Madjid Batoe Muara Bulian. Minimarket ini tergolong masih baru karena beroperasi sejak tahun 2020. Meskipun baru, minimarket ini cukup ramai dikunjungi oleh konsumen yang berbelanja, hal ini dikarenakan pemilihan lokasi yang tepat dari manajemen Ghania Mart. Produk yang tersedia di Ghania Mart lebih didominasi oleh kebutuhan bahan pokok seperti beras, minyak sayur, gula, garam dan lainnya. Selain itu juga tersedia produk lain seperti makanan instan dan minuman instan dengan berbagai merk dan variasi rasa. Ghania Mart beroperasi mulai dari pukul 08.00 sampai pukul 21.00 WIB. Metode yang penulis gunakan dalam penelitian ini adalah library research atau penelitian labor. Dalam penelitian ini, penulis menggunakan teknik pengayaan data mining. Adapun algoritma yang penulis gunakan dalam penambagnan data ini adalah Algoritma FP-Growth. Sedangkan software yang digunakan adalah Weka Data Mining. Hasil penelitian ini membuktian algoritma FP-Growth memiliki kecepatan dalam pemrosesan data yang terbantu dari pembentukan FP-Tree. Pengujian menggunakan software data mining Weka didapatkan 4 rule terbaik. Kombinasi Masker dan Kopi memiliki support 10% dan confidence mencapai 93%.
Analisis dan Perancangan Sistem Informasi Kasir Pada Restoran The Tempoa Jelutung Jambi
Authors: Meisak Despita 
Published: August 2021

Restoran Tempoa Jelutung Jambi telah berdiri sejak tahun 2010. Saat ini, restoran masih menggunakan nota manual sehingga sering terjadi kesalahan kalkulasi, tulisan tangan tidak rapi, dan kesulitan untuk menata tagihan manual tersebut, khususnya pada saat pengunjung ramai sehingga membuat pelanggan harus menunggu lama untuk transaksi pembayarannya, Untuk meningkatkan performa, diperlukan sebuah sistem berbasis komputer untuk meningkatkan kinerja karyawan dan pelayanan jasa terutama kasir yang melayani transaksi pembayaran pelanggan. Penelitian ini diawali dengan identifikasi permasalahan, mempelajari literatur penelitian sejenis yang sesuai dengan permasalahan yang terkait di restoran ini, serta mengumpulkan data guna menganalisa kebutuhan sistem. Sistem dimodelkan dengan use case diagram, activity diagram dan class diagram dan prototype perangkat lunak dengan alat bantu visual basic 6.0, sehingga menghasilkan sistem informasi kasir untuk membantu kasir agar dapat memproses transaksi pelanggan dengan efektif dan efisien, meminimalisir kesalahan input data pesanan pelanggan serta mempermudah dalam penyiapan laporan penjualan
Aplikasi Jambiku Bersih Dengan Permodelan Mengunakan UML
Authors: Husni Akhmad Faisal , Oktarino Ade 
Published: August 2021

Penanganan Sampah merupakan permasalahan yang dihadapi pemerintah Kota Jambi khususnya Dinas Lingkungan Hidup (DLH) Kota Jambi. Permasalahan yang terjadi dilapangan antara lain jadwal pengangkutan sampah, pengawasaan petugas di lapangan serta transparansi dalam penyampaian informasi. Penelitian ini dilakukan untuk membuat permodelan aplikasi bagi masyarakat agar memperoleh informasi mengenai lokasi Tempat Pembuangan Sampah, kegiatan dinas terkait dan membuat pengaduan pengelolaan sampah sebagai sarana pengawasan pimpinan DLH kota Jambi terhadap kinerja petugas di lapangan. Pengembangan sistem menggunakan metode waterfall dan pemodelan kebutuhan sistem digambarkan dengan diagram Unified Modeling Language (UML). Aplikasi Jambiku Bersih membantu masyarakat kota Jambi dalam mendapatkan informasi terkait pembuangan sampah, pengawasan terhadap kinerja petugas di lapangan serta memberikan informasi untuk meningkatkan pelayanan DLH Kota Jambi.
Perbandingan Analisis Kepuasan Pengguna Jaringan Internet Telkomsel Menggunakan R Programming dan Menggunakan Cara Manual
Authors: Kelik  
Published: August 2021

Pada jaman modern, sebagian besar masyarakat tidak terlepas dari internet. Banyak provider dari kartu telekomunikasi yang menyediakan fasilitas internet. Salah satu provider tersebut adalah Telkomsel. Telkomsel merupakan provider yang cukup besar di Indonesia dan banyak penggunanya bukan hanya di perkotaan tetapi juga di pelosok tanah air karena jangkauan jaringan Telkomsel yang bisa menjangkau hampir seluruh wilayah terpencil di Indonesia. Namun, pada waktu-waktu tertentu pasti ditemui gangguan jaringan internet yang mampu mempengaruhi kepuasan pengguna jaringan internet Telkomsel. Oleh karena itu, perlu dilakukan analisis terkait kepuasan pengguna. Penulis memanfaatkan komentar masyarakat pada twitter untuk melakukan analisis tersebut. Analisis jaringan internet Telkomsel dilakukan dengan dua cara yaitu analisis otomatis dengan R Programming dan secara manual dengan polling responden. Hasil dari kedua analisis tersebut sama-sama menunjukkan kategori tidak puas walaupun dengan persentase yang berbeda tetapi keduanya sama-sama menunjukkan hasil tidak puas untuk hasil yang terbanyak. Untuk hasil analisis dengan R Programming tidak puas sebesar 14,5% sedangkan analisis secara manual sebesar 61%. Hasil analisis yang digunakan dalam perbandingan hanya kategori puas dan tdak puas dan penulis mengabaikan hasil dari kategori netral, karena netral tidak mengandung emosi apapun. Dari kedua analisis yang dilakukan penulis, analisis otomatis dengan R Programming lebih efektif dan efisien karena mulai dari awal proses crawling twitter sampai dengan hasil analisis dan visualisasinya bisa dilakukan dengan lebih cepat.
Kata kunci: Crawling, Jaringan Internet, Provider, R Programming.