bluuebunny/crossref_metadata_2025_split huggingface dataset:
SUMO1 modification of IGF-1R combining with SLUG inhibited osteogenic differentiation of PDLSCs stimulated by high glucose
Authors: Jiang Rongrong , Wang Miao , Shen Xiaobo , Huang Shuai , Han Jianpeng , Li Lei , Xu Zhiliang , Jiang Chengfeng , Zhou Qiao , Feng Xingmei 
Published: March 2021

Abstract
Background: Periodontal disease, an oral disease characterized by loss of alveolar bone and progressive teeth loss, is the sixth major complication of diabetes. It is spreading worldwide as it is difficult to be cured. The insulin-like growth factor 1 receptor (IGF-1R) plays an important role in regulating functional impairment associated with diabetes. However, it is unclear whether IGF-1R expression in periodontal tissue is associated with periodontal bone tissue destruction in diabetic patients. SUMO modification has been reported in various diseases and are associated with an increasing number of biological processes, but previous studies have not focused on diabetic periodontitis.Methods: Periodontal membrane stem cells (PDLSCs) were isolated and cultured from healthy human obstructed teeth after extraction or adolescent orthodontic subtractive extraction. PDLSCs were cultured with medical 5% sterile glucose solution formulated as osteogenic differentiation induction solution with different glucose concentrations. The effects of different glucose concentrations on the osteogenic differentiation ability of PDLSCs were investigated at the genetic and cellular levels using staining assay, Western Blot, RT-PCR, Co-IP and cytofluorescence.Results: We found that SLUG, RUNX2 expression was decreased in PDLSCs cultured in high glucose osteogenic induction solution compared with normal glucose osteogenic induction solution. In addition, the IGF-1R expression levels, osteogenic differentiation and sumoylation of IGF-1R in PDLSCs cultured in high glucose osteogenic induction solution were not consistent with those cultured in normal glucose osteogenic induction solution.Conclusion: Our data demonstrated that SUMO1 modification of IGF-1R in high glucose environment inhibited osteogenic differentiation of PDLSCs by binding to SLUG, a key factor leading to periodontal bone tissue loss in diabetic patients. Thus we can maximize the control of multiple downstream damage signaling factors and bring new hope for periodontal tissue regeneration in diabetic patients.
Combined exercise training-induced improvements in executive functions are related to baseline plasmatic levels of Brain-Derived Neurotrophic Factor (BDNF) in middle-aged adults and older with Type 2 Diabetes Mellitus
Authors: Silveira-Rodrigues João Gabriel da , Nogueira Nathálya Gardênia de Holanda Marinho , Faria Larissa Oliveira , Pereira Daniele Sirineu , Soares Danusa Dias 
Published: March 2021

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) affects many cognitive functions and aerobic plus resistance exercise training, named combined training (CT), by improving metabolic control may mitigate or reverse the cognitive impairment T2DM-related. Brain-derived neurotrophic factor (BDNF) plays a substantial role in cognitive functions. However, the effects of CT on BDNF levels of T2DM subjects are poorly known.Aim: This study analyzed the effects of 8 weeks of CT on circulating BDNF levels and assessed whether plasmatic BDNF levels were related to CT-induced improvements in executive functions and long-term memory of T2DM subjects.Methods: Thirty-five (63 ± 8 years old) T2DM subjects of both sexes entered into CT (n = 17, thrice-weekly during 8 weeks) or control group (CONT, n = 18). Executive functions (measured through Trail making test, Stroop color task, and Digit Span), long-term memory (measured through the simplified version of Taylor Complex Figure Test), and blood samples were evaluated pre- and post-intervention.Results: Pre-CT plasma BDNF levels were positively related to CT-induced improvements on executive functions composite z-score (r = 0.71), inhibitory control (r = 0.58) and cognitive flexibility (r = 0.56), but not to long-term memory. Plasma BDNF levels were not statistically changed (pre-CT: 179 ± 88 pg/ml; post-CT: 148 ± 108 pg/ml; pre-CONT: 163 ± 71 pg/ml; post-CONT: 141 ± 84 pg/ml, p > 0.05).Conclusion: Higher pre-training BDNF levels might be a potentializing factor of the training-induced improvements on executive functions, independently of the training-alterations in resting BDNF levels of T2DM subjects.
Synthesis of some new 1-(5-((1H-pyrazol-1-yl)methyl)-2-aryl-1,3,4-oxadiazol-3(2H)-yl) ethanone derivatives and study their antimicrobial activity
Authors: Asif Mohammad , Alghamdi Saad , Alshehri Mohammed M. , Kamal Mehnaz 
Published: March 2021

Abstract
Ethyl 2-(1H-pyrazol-1-yl)acetate (1) was synthesized by the reaction of ethylchloroacetate with 1H-pyrazole, Then compound (1) refluxed with hydrazine hydrate to get 2-(1H-pyrazol-1-yl) acetohydrazide (2). Compound (2) was reaction with appropriate aryl aldehyde to get schiff bases N'-arylidine-2-(1H-pyrazol-1-yl)acetohydrazide derivatives (3a-3f). schiff’s base (3a-3e) were cyclized by reflux with acetic anhydride to get new 1-(5-((1H-pyrazol-1-yl)methyl)-2-aryl-1,3,4-oxadiazol-3(2H)-yl)ethanone derivatives (4a-4e). The structures of the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectra, and elemental analysis data. Synthesized compounds (4a-4e) were evaluated as antibacterial agents against some common pathogenic bacteria Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative bacteria (Escherichia coli, Psuedomonas aeruginosa). The result of antibacterial activity was compared with standard drugs (Ciprofloxacin and Tetracycline).
Insulin Increases Central Aortic Stiffness in Response To Hyperglycemia in Healthy Humans: A Randomized Four-Way Crossover Study
Authors: Horton William B , Jahn Linda A , Hartline Lee M , Aylor Kevin W , Patrie James T , Barrett Eugene J 
Published: March 2021

Abstract
Introduction: Increasing arterial stiffness is a feature of vascular aging that is accelerated by conditions that enhance cardiovascular risk, including diabetes mellitus. Multiple studies demonstrate divergence of carotid-femoral pulse wave velocity and augmentation index in persons with diabetes mellitus, though mechanisms responsible for this are unclear.Materials and Methods: We tested the effect of acutely and independently increasing plasma glucose, plasma insulin, or both on hemodynamic function and markers of arterial stiffness (including carotid-femoral pulse wave velocity, augmentation index, forward and backward wave reflection amplitude, and wave reflection magnitude) in a four-arm, randomized study of healthy young adults.Results: Carotid-femoral pulse wave velocity increased only during hyperglycemic-hyperinsulinemia (+0.36 m/s; p=0.032), while other markers of arterial stiffness did not change (all p>0.05). Heart rate (+3.62 bpm; p=0.009), mean arterial pressure (+4.14 mmHg; p=0.033), central diastolic blood pressure (+4.16 mmHg; p=0.038), and peripheral diastolic blood pressure (+4.09 mmHg; p=0.044) also significantly increased during hyperglycemic-hyperinsulinemia.Conclusions: Hyperglycemic-hyperinsulinemia acutely increased cfPWV, heart rate, mean arterial pressure, and diastolic blood pressure in healthy humans, perhaps reflecting enhanced sympathetic tone. Whether repeated bouts of hyperglycemia with hyperinsulinemia contribute to chronically-enhanced arterial stiffness remains unknown. (ClinicalTrials.gov number NCT03520569; registered 9 May 2018).Clinical Trial Information: ClinicalTrials.gov identifier NCT03520569 (registered 9 May 2018).
Hansegeschichte als Organisationsgeschichte versus Hansegeschichte als Wirtschaftsgeschichte
Authors: Kypta Ulla 
Published: March 2021

Hanseatic history – organizational history or economic history? Some thoughts on embedding Hanseatic research in international research strands. This article is concerned with the broader framework within which Hanseatic research is conducted. It is my contention that Hanseatic historians could sharpen their focus and attain more profound insights if they decided whether to conduct organizational studies or pursue economic history. It is not possible to do both simultaneously. Organizational and economic research not only work with different models which have theoretical underpinnings distinct from one another, they also pursue different agendas: Organizational research investigates the structures, processes and transformations of an organization, in order to answer the question: Why and how did a particular organization survive? Economic history, by contrast, studies the structures, processes and transformations of economic regions or systems, as well as the actions and motives of economic agents, notably employing efficiency as a criterion for judging those actions. At the moment, Hanseatic research tends to treat both questions indiscriminately and to assume that the stability or longevity of an organization suffices to demonstrate its efficiency. However, as recent developments in organizational research show, an inefficient organization can survive for a surprisingly long time. We must therefore study both criteria – longevity and efficiency – separately.
Part one of the article suggests avenues for future research on Hanseatic history within the broader framework of organizational studies. Current research presents a working definition of an organization as an institution that gained legitimacy and identity. While it is not useful to regard “the Hanse” as a whole (whatever that might have been) as an organization, the Kontors, the town councils and probably the circle of friends of Hanseatic merchants can indeed be regarded as organizations. Part two takes a closer look at Hanseatic merchants, evaluating their success as economic actors. Three questions have to be clarified if Hanseatic historians want to discuss their findings with other economic historians: First, how do we measure ‘success’? Second, whom do we regard as a ‘Hanseatic merchant’? And third, why would it be interesting for economic historians to know whether or not Hanseatic merchants were successful? The article thus hopes to pave the way for the re-connection of Hanseatic research to broader research fields.
Untersuchungen zum Hansebild Fritz Rörigs
Authors: Förster Ulrike 
Published: March 2021

History was grist to the mill of Nazi propaganda, and the medieval Hanse was no exception. Fritz Rörig, a historian, was heavily involved in the instrumentalisation of Hanseatic history during the Third Reich. This paper analyses his writings before and during the Nazi period. What narrative patterns, phraseology and political content do they exhibit? The articles Rörig wrote in the first half of the 1940s display the typical stylistic devices and narrative patterns – indeed the buzz words – of Nazi propaganda, but impacts of racial ideology are not discernable. Indeed, some sections of these essays could be seen to constitute criticism of those in power. Despite this, the conclusion is unavoidable that Rörig was ready and willing to instrumentalise Hanseatic history for Nazi propaganda purposes. However, even before 1933, Rörig had viewed the Hanse through the lens of political ideology. What changed was not the Instrumentalisation of Hanseatic history itself, but Rörig’s political position and, in consequence, the picture of the Hanse he presented. Before the Nazi period, Rörig had been something of a free-market liberal, albeit one of a distinctly conservative and nationalist bent. Accordingly, he spotlighted the vital role of the bourgeoisie in the development of the Hanse, particularly in lectures for a broader public.
Prediction of dynamic deformation development of soil using Gompertz curve
Authors: Chen Deling , Li Guodong 
Published: March 2021

In recent years, the influence of earthquake on geotechnical engineering has been paid more and more attention, and the study of soil dynamic characteristics is the most important part. In order to reveal the dynamic characteristics of the silty clay in the reservoir area of the hydropower station, firstly many samples are taken for dry-wet cycle several times to simulate the changes of soil in the reservoir slope under the condition of reservoir water level change or rainfall evaporation. And then dynamic triaxial tests are carried out on those samples to determine the dynamic deformation development law of the soil. The model is established based on Gompertz curve, making it be applied to the deformation curve of soil dynamics. The dynamic deformation curve of samples after different times of dry-wet cycle is fitted. The error of fitting value and actual value is within 5 %, and the relationship between vibration frequency and dynamic strain is established. The research results have practical significance for the prediction of dynamic deformation of soil and the application of Gompertz curve.
Intra-operative Clodronate Rinsing Improves the Integration of the Femoral Stem in a Prospective, Double-blinded, Randomized, Placebo-controlled Clinical RSA-study
Authors: Kiuttu Jukka , Lehenkari Petri , Leskelä Hannu-Ville , Yrjämä Olli , Ohtonen Pasi , Valkealahti Maarit 
Published: March 2021

Background:
Periprosthetic bone loss after Total Hip Arthroplasty (THA), detected as an early migration of the prosthesis may predict later loosening of the implant.

Objective:
We hypothesized that intra-operative bisphosphonate rinsing would reduce bone resorption after THA. It might therefore be possible to achieve better early fixation of the implant.

Methods:
Nineteen patients suffering from arthrosis were recruited in a prospective, double-blinded, randomized, placebo-controlled clinical pilot trial. Patients were operated with an uncemented Bimetric stem using tantalum markers. The femoral proximal intramedullary canal was rinsed with 1mM clodronate in nine patients and with saline in 10 patients. These patients were followed for two years using radiostereometric analysis (RSA), dual energy x-ray absorptiometry (DXA) and the Harris Hip Score (HHS).

Results:
We did not found any significant differences between the study groups with regards to the primary output measures (maximum total point motion, MTPM). However, there was evidence that clodronate could affect periprosthetic bone quality; a beneficial effect in BMD in Gruen zone 3 during the two-year follow-up was observed, BMD decreased less in the clodronate group (p = 0.02). The maximal x-translation of the stem at 3-24 months was significantly two-fold, being higher in the placebo group (p = 0.02). The baseline BMD and the maximal total point motion (MTPM) at 3-24 months showed a positive correlation in the clodronate group and a negative correlation in the placebo group.

Conclusion:
In conclusion, further studies with larger patient groups and longer follow-up periods are needed to estimate the clinical importance of these findings and further to prove if an intraoperative clodronate rinsing prior to application of femoral stem during THA can prevent periprosthetic bone loss.
Clinical Trial Registration No.: NCT03803839
ACE2 Shedding and Furin Abundance in Target Organs may Influence the Efficiency of SARS-CoV-2 Entry
Authors: Ma Yuanchen , Huang Yinong , Wang Tao , Xiang Andy Peng , Huang Weijun 
Published: March 2021

Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a lineage B coronavirus, causing the worldwide outbreak of Corona Virus Disease 2019 (COVID-19). Despite genetically closed to SARS-CoV, SARS-CoV-2 seems to possess enhanced infectivity and subtle different clinical features, which may hamper the early screening of suspected patients as well as the control of virus transmission. Unfortunately, there are few tools to predict the potential target organ damage and possible clinical manifestations caused by such novel coronavirus.

Methods:
To solve this problem, we use the online single-cell sequence datasets to analyze the expression of the major receptor in host cells that mediates the virus entry, including angiotensin converting enzyme 2 (ACE2), and its co-expressed membrane endopeptidases.

Results:
The results indicated the differential expression of ADAM10 and ADAM17 might contribute to the ACE2 shedding and affect the membrane ACE2 abundance. We further confirm a putative furin-cleavage site reported recently in the spike protein of SARS-CoV-2, which may facilitate the virus-cell fusion. Based on these findings, we develop an approach that comprehensively analyzed the virus receptor expression, ACE2 shedding, membrane fusion activity, virus uptake and virus replication to evaluate the infectivity of SARS-CoV-2 to different human organs.

Conclusion:
Our results indicate that, in addition to airway epithelia, cardiac tissue and enteric canals are susceptible to SARS-CoV-2 as well.
Public Seminar: America's Battle for Media Democracy
Authors: Chen Sibo 
Published: March 2021

(Post on behalf of Dr. Enda Brophy)
There will be a public seminar with Prof. Victor Pickard on his new book "America's Battle for Media Democracy". The seminar will take place on April 7, 2015 between 3:00 and 5:00 pm at room 2270, Habour Center. Please see the attached poster for details.
Public Event: Brown Bag Lecture Series: Journalisms for Climate Crisis
Authors: Ackerley Christine Rose 
Published: March 2021

The next Brown Bag Seminar is at noon on March 9th, 2016 at SFU Burnaby in the Mallinson Conference room, K8652. Dr. Shane Gunster and Dr. Robert Hackett, both from the School of Communication will be speaking on the topic of "Journalisms for Climate Crisis". For more information, please see the PDF poster.
Public Event: US Military Occupation of Okinawa: film & discussion with John Junkerman
Authors: Ackerley Christine Rose 
Published: March 2021

The Institute for Transpacific Cultural Research is hosting a film screening and discussion of John Junkerman’s film, Okinawa: Afterburn, on the US military occupation of Okinawa. Issues regarding the Cold War, Japanese Imperialism, Japan’s article 9, and the US military and resistance movements will be highlighted.The event is also hosted by VanCity Office of Community Engagement and the School of Communication along with the Peace Philosophy Centre It will be screened on November 17th at 5PM, room 1530 at Harbour Centre.
Public Event: Free Public Lecture: Dr. Jaimie Baron
Authors: Ackerley Christine Rose 
Published: March 2021

Dr. Jaimie Baron, an Assistant Professor of Film Studies at the University of Alberta, will present a lecture on the ethics of sonic appropriation, on Friday, November 18, 2016 from 4:00pm-6:00pm at Harbour Centre, Room 7000. Please see the poster attached for more details.
Public Event: Lecture: Re-Imagining Affect: A Dialectic Conceptualization
Authors: Ackerley Christine Rose 
Published: March 2021

Peter Zuurbier and Frédérik Lesage will present a talk titled "Re-Imagining Affect: A Dialectic Conceptualization" on Thursday, December 1, from 6:00pm–8:00pm in Room 7000 at SFU Harbour Centre.The event is co-sponsored by SFU's Institute for the Humanities and School of Communication. For more details, please see the PDF poster attached.
Public Event: Visual and Sonic Imaginations: Montage as Illusion
Authors: Ackerley Christine Rose 
Published: March 2021

On January 19th, 2017, Alexandrine Boudreault-Fournier from Anthropology, University of Victoria in conversation with Vincent Andrisani from the School of Communications, SFU will present CONVERSATIONS WITH UNUSUAL SUSPECTS on the sensorial, art and ethnography: A new seminar series by the Centre for Imaginative Ethnography (CIE) & the Institute for Performance Studies (IPS), in HC room 7000 at 3:00-5:30 pm. Please see the attached poster for details.
Public Event: Dallas Smythe Memorial Lecture: Life and Liberatory Communications in the Age of Trump
Authors: Ackerley Christine Rose 
Published: March 2021

Dr. Dorothy Kidd will be giving the annual Dallas Smythe Memorial Lecture, entitled "Life and Liberatory Communications in the Age of Trump" on Thursday, March 16 at 7:00 pm in Harbour Centre room 1400-1410.
Dr. Dorothy Kidd teaches media studies at the University of San Francisco. Her two current research projects examine the use of contentious communications by political and social justice movements, including a longitudinal study of the San Francisco Bay area, and a trans-national study of trans-local movements against extractivism.
Please see the attached poster for more details.
Public Event: Stream Sessions
Authors: Ackerley Christine Rose 
Published: March 2021

The first Stream Session will be on Wednesday, March 29 from 2:00-4:00 pm at the conference room at the Burnaby Campus (8652). Stream Sessions are intended to be a colloquium where graduate students are invited to present their ideas to fellow students and faculty of the School of Communication. Topics for presentation can range from working papers to discussions of comprehensive or thesis readings to new theories and ideas still in the process of being formed. Itâ€™s an opportunity to workshop ideas among peers in a productive yet low-stakes environment while also receiving valuable feedback from students and faculty.
For more details, please see the attached PDF.
The following students will be presenting work for the first Stream Sessions. Each presentation will run 10-15 minutes with 15 minutes for discussion afterward.
Stream Sessions - Wednesday March 29 2:00-4:00 pm SFU Burnaby Room 8652
2:00-2:30 - Alberto Lusoli (PhD Student) - â€œFrom Social to Critical Constructivism. An Exploration of the Main Schools of Thought in the Field of Science, Technology and Society"
2:30-3:00 - Geneva Lam (Masterâ€™s Student) - â€œExplaining Ethnic Media through the Lens of Language, Identity and Culture â€œ
3:00-3:30 - Shawna-Kay Thomas (Double-Degree Masterâ€™s Student) - â€œâ€˜Portia Loves the Poorâ€™ - Portia Simpson Miller and Affective Politics in Jamaicaâ€
3:30-4:00 - Peter Zuurbier and Darren Fleet (PhD Students) â€œIt Just Feels Right: Affective Veridiction in the Contemporary West.â€
Faculty Referee: FrÃ©dÃ©rik Lesage
There will be light refreshments served. Following the event, we encourage everyone attending and participating to make their way to the Highland Pub for drinks and continued conversation.