bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristics
Authors: Lu YuFen , Chen Yu , Zhang ZiYu , Li MingMei , Chen XiaoXiao , Tu KaiJia , Li LongYu 
Published: December 2021

AbstractIn most cases of cervical cancer, the high risk of the disease is caused by the human papilloma virus (HPV). Surgery or radiation usually benefits patients with early cervical cancer, while the metastatic one is uncurable and new therapeutic strategies and approaches are required. In this study, HPV16 E6 silence or overexpression were carried out to evaluate the possible mechanisms of HPV16 E6 function in cervical cancer cells with different HPV16 E6 expression background. HPV16 E6‐positive cervical cancer cell Siha exerts significantly stronger cell invasion and migration potentials than the HPV16 E6‐negative C33A cells. HPV16 E6 silence significantly weakened the potentials of cell invasion and migration, cell proliferation and stemness characteristic in Siha cells. Meanwhile, the overexpression of HPV16 E6 effectively promoted the cell proliferation and stemness characteristic in C33A cells. Our data also indicated a positive association between HPV16 E6 and the levels of epithelial to mesenchymal transition (EMT), and cell stemness. The ectopic expression of OCT4 could effectively reverse the inhibitory roles of HPV16 E6 silence on cell migration, invasion, and stemness in Siha cells. More interestingly, we found that HPV16 E6 might promote the OCT4 expression by impairing the direct binding of p53 on the promoter and activate its transcription. Taken together, our results indicated that HPV16 E6 could promoted the potential cell proliferation, migration, and invasion of human cervical cancer cells by modulating EMT and cell stemness. Our data provide a novel mechanism for how HPV16 E6 acts as a key risk factor for cervical cancer development and progression.
Proteinase 3 associated with Wegener's granulomatosis
Authors: Goldmann Wolfgang H. 
Published: December 2021

AbstractWegener's granulomatosis (WG) is a form of systemic vasculitis characterized by granulomatous inflammation of the upper and lower airways, vasculitis, and necrotizing glomerulonephritis. It is strongly associated with anti‐neutrophil cytoplasmic antibodies against proteinase 3 (PR3‐ANCAs). Various in vitro observations provided strong evidence that autoimmune PR3‐ANCAs are directly involved in glomerular and vascular inflammation. However, little is known about the pathogenic significance of PR3‐ANCAs in vivo. Therefore, the generation of animal models helped to validate the suggested autoimmune origin and pathophysiology in WG. To characterize and improve the models, numerous studies were carried out to elucidate the effect of mouse/rat PR3‐ANCAs on neutrophil function as well as the role of CD4/CD8 in T and B cells and antibodies in the pathogenesis of the disease. Understanding the pathogenesis is therefore critical to relate these models to human studies hoping that they will be useful for better insight of WG and the development of specific therapies for the disease.
Challenges in corticosteroid dose regulation in a patient with autoimmune thyroid disease and neuropsychiatric syndrome: A running commentary
Authors: Bidaki Reza , Saghafi Fatemeh , Ahrari Samira , Aghamollaii Vajiheh , Rahmani Mojde , Asadi Ahdie 
Published: December 2021

AbstractIn the following, we report a therapeutic challenge faced by reduction in corticosteroid therapeutic dosage in a patient diagnosed with Hashimoto's encephalopathy (HE), which is equivalent to corticosteroid‐responsive encephalopathy related to autoimmune thyroiditis and often misdiagnosed as neuropsychiatric status. The patient developed psychiatric symptoms.
Reddish multilobulated mass on the scalp in a 13‐year‐old girl
Authors: Ben Rejeb Mohamed , El Mabrouk Randa Said , Ben Cheikh Sirine , Sriha Badreddine , Ghariani Nejet , Denguezli Mohamed 
Published: December 2021

AbstractNodular hidradenoma is a rare benign adnexal tumor that occurs as a solitary nodule with a predilection for the head, face, and upper extremities. We describe the case of nodular hidradenoma presenting as an expanding nodule on the scalp. This tumor is a simulator of malignant lesions on clinical and dermoscopic examination. Our case emphasizes the importance to identify this tumor as a differential for scalp lesions.
N‐Heterocyclic Phosphines as Precatalysts for the Highly Selective Degradation of Poly(lactic acid)
Authors: English Laura E. , Jones Matthew D. , Liptrot David J. 
Published: December 2021

AbstractAn N‐heterocyclic phosphine (NHP) has been investigated as a catalyst for transesterification of a range of commercial polymer samples. NHP catalysed degradation of poly(lactic acid) with methanol provides access to methyl lactate (MeLA) in high yields over the course of days. In situ NMR spectroscopy and kinetic analysis has provided quantitative assessment of the catalyst, and a solvent screen is reported. Surprisingly attempts to depolymerise polycaprolactone (PCL) and polyethylene terephthalate (PET) were unsuccessful, and reactions mixed PLA/PCL and PLA/PET provided completely specific degradation of the PLA alone. NMR analysis of the catalyst provides insight into its solution speciation, indicating that the NHP does not remain intact under the transesterification conditions. The enediamine, tBuN(H)CH=CHN(H)tBu, was shown to be formed via methanolysis of the NHP and proved to be a selective catalyst for PLA degradation. Assessment of the depolymerisation activity of by‐products of the NHP methanolysis suggest this is the active catalyst.
„GES‐2“ Moskau – Verwandlung vom Kraftwerk zur Stätte für Kunst und Kultur – Ein Treffen von historischer Bausubstanz mit modernem Stahl‐/Glasbau
Authors: Zimmermann Stefan , Schmitt Felix 
Published: December 2021

AbstractDas Industriedenkmal „GES‐2“ im Herzen Moskaus wird durch die V–A–C–Stiftung in eine Begegnungsstätte für Kunst und Kultur konvertiert. Die Restaurierung und Umnutzung, die auf Basis der Planung von Renzo Piano Building Workshop (RPBW) erfolgt, bewahrt die historische Bausubstanz und fügt moderne Elemente auf höchstem technischem und energetischem Standard hinzu. Das Gebäude erhält z. B. ein neues filigranes Stahl‐/Glasdach mit Photovoltaikelementen und neue Stahl‐/Glasfassaden aus Sonderprofilen, die sich an die historischen Verglasungen anlehnen. Der Artikel stellt die Herausforderungen dar, die sich aus der Vereinigung von historischer Bausubstanz mit Elementen des modernen Stahl‐/Glasbaus bei Planung, Fertigung und Montage ergeben.“GES‐2” Moscow. Transformation from a power plant to a place for art and culture. An encounter of historical building structure with modern steel/glass construction. The industrial monument “GES‐2” in the heart of Moscow will be transformed by the V–A–C–Foundation into a meeting place for art and culture. The restoration and conversion based on the architectural design of Renzo Piano Building Workshop (RPBW), preserves the historical structure and adds modern elements of the highest technical and energy standards. The building receives, for example, a new filigree steel/glass roof with photovoltaic elements and new steel/glass facades made of special profiles that follow the historical glazing. The article presents the challenges arising from the combination of historical building structure with elements of modern steel/glass construction in design, production and installation.
Nationale Glasbaunormung – Überarbeitung von DIN 18008 Teile 3, 4 und 5
Authors: Siebert Geralt 
Published: December 2021

AbstractNachdem die Teile 1 und 2 der DIN 18008 mit Datum Mai 2020 (endlich) im Weißdruck erschienen sind, werden die darauf abgestimmten Teile 3, 4 und 5 überarbeitet. Der Beitrag gibt einen Überblick über die angedachten Änderungen sowie Hintergründe dazu. Die Novellierung des Bauordnungsrechts macht– wie auch schon bei den Teilen 1 und 2 – einige Änderungen erforderlich (Stichworte VSG, Heißlagerung von ESG). Der Entwicklung des Stands der Technik sind die meisten Änderungen bzw. Erweiterungen geschuldet, beispielhaft sind zu nennen die Berücksichtigung von flächenbündigen Punkthaltern in konusförmigen Glasbohrungen, eine Überarbeitung der Klassifizierung und Nachweisführung absturzsichernder Verglasungen oder die Diskussion über Aufnahme von Regelungen für Ganzglasanlagen geringerer Einbauhöhe. Abschließend ein kleiner Ausblick auf die Situation der europäischen Normungsaktivitäten.National glass design standardization – Revision of DIN 18008 parts 3, 4 and 5. After Parts 1 and 2 of DIN 18008 with the date May 2020 (finally) have been published in final version, Parts 3, 4 and 5 will be revised. This article gives an overview of the planned changes as well as background information. The amendment of the federal building laws makes some changes necessary, as is was already the case with Parts 1 and 2 (keywords laminated safety glass, heat soak test of tempered safety glass). The development of the state of the art is the reason for most of the changes and extensions, for example the consideration of flush point fixings in conical glass holes, a revision of the classification and verification of barrier glazing, the discussion about the inclusion of regulations for all‐glass systems of lower installation height. Finally, a brief outlook on the situation of European standardization activities is given.
Bewertung der Ressourceneffizienz einer neu entwickelten Holz‐Glas‐Hülle im mehrgeschossigen Hochbau
Authors: Fadai Alireza , Stephan Daniel 
Published: December 2021

AbstractDie zeitgenössische nachhaltige Architektur reagiert auf den umweltpolitischen Wandel und beschäftigt sich mit den Baustoffen Holz und Glas in der Fassade, sowie der bauphysikalischen Optimierung der Gebäudehülle. Im Rahmen der aktuellen Forschungsprojekte befassten sich die Autoren mit der energieeffizienten Optimierung von Gebäudehüllen im mehrgeschossigen Hochbau. Anhand der durchgeführten Parameterstudie für entwickelte Holz‐Glas‐Hybridelemente konnte bei Minimierung des Energie‐ und Ressourcenbedarfs eine effiziente Anordnung, sowie optimale Anteile der opaken Elemente ermittelt werden. Dies erfolgt hinsichtlich der Materialwahl auf Bauteilebene, sowie anhand daraus resultierender thermischer und ökologischer Simulationen auf Gebäudeebene, wodurch eine maßstabsunabhängige Bewertung der untersuchten Konstruktionen möglich wird.The evaluation of resource efficiency of developed hybrid timber‐glass envelopes for multi‐story building construction. Contemporary sustainable architecture reacts to the environmental change and focuses on the building materials timber and glass construction as well as the optimization of the building envelope regarding building physics. In the context of the current research projects, the authors dealt with the energy‐efficient optimization of building envelopes in multi‐story building construction. Based on the parameter study for developed timber‐glass hybrid elements, an efficient arrangement as well as optimal proportions of opaque elements could be determined while minimizing the energy and resource requirements. This is done with regard to the choice of materials at the component level, as well as on the basis of the resulting thermal and ecological simulations at the building level, which allows a scale‐independent evaluation of the examined constructions.
Biegezugfestigkeit von emailliertem Flachglas unter Variation des Farbauftrages
Authors: Wünsch Jan , Wittwer Jost , Weller Bernhard 
Published: December 2021

AbstractEmaillierte Gläser mit thermischer Vorspannung weisen gegenüber gleichartigen unbedruckten Gläsern eine geringere technische Biegezugfestigkeit an der bedruckten Oberfläche auf. Die relative Festigkeitsminderung hängt dabei unter anderem vom Auftragsverfahren und der sich daraus ergebenden Schichtstärke der Emaillierung ab. Dieser Beitrag stellt die Ergebnisse von Biegeprüfungen im Vierschneidenverfahren nach Norm DIN EN 1288‐3 an siebbedruckten, digital bedruckten und mit Siebdruckfarbe besprühten Einscheiben‐Sicherheitsgläsern vor.The Bending Tensile Strength of Enamelled Glazing under Variation of the Color Applications. Enameled glass with thermal tempering has a lower bending strength on the printed surface compared to similar unprinted toughened safety glass. The relative reduction in strength depends, among other things, on the application process and the resulting layer thickness of the enamel. This paper presents the results of four‐point‐bending‐tests according to the DIN EN 1288‐3 standard on different printed glass. The toughened safety glass has screen‐printed or digitally printed surfaces or has surfaces sprayed with screen printing ink.
C(spn)−X (n=1–3) Bond Activation by Palladium
Authors: Hansen Thomas , Sun Xiaobo , Dalla Tiezza Marco , van Zeist Willem‐Jan , Poater Jordi , Hamlin Trevor A. , Bickelhaupt F. M. 
Published: December 2021

AbstractWe have studied the palladium‐mediated activation of C(spn)−X bonds (n = 1–3 and X = H, CH3, Cl) in archetypal model substrates H3C−CH2−X, H2C=CH−X and HC≡C−X by catalysts PdLn with Ln = no ligand, Cl−, and (PH3)2, using relativistic density functional theory at ZORA‐BLYP/TZ2P. The oxidative addition barrier decreases along this series, even though the strength of the bonds increases going from C(sp3)−X, to C(sp2)−X, to C(sp)−X. Activation strain and matching energy decomposition analyses reveal that the decreased oxidative addition barrier going from sp3, to sp2, to sp, originates from a reduction in the destabilizing steric (Pauli) repulsion between catalyst and substrate. This is the direct consequence of the decreasing coordination number of the carbon atom in C(spn)−X, which goes from four, to three, to two along this series. The associated net stabilization of the catalyst–substrate interaction dominates the trend in strain energy which indeed becomes more destabilizing along this same series as the bond becomes stronger from C(sp3)−X to C(sp)−X.
Enantioselective Reductive Cross‐Coupling of Aryl/Alkenyl Bromides with Benzylic Chlorides via Photoredox/Biimidazoline Nickel Dual Catalysis
Authors: Li Tongtong , Cheng Xiaokai , Lu Jiamin , Wang Huifeng , Fang Qun , Lu Zhan 
Published: December 2021

Comprehensive SummaryThe asymmetric reductive arylation and alkenylation of benzylic chloride under photoredox/nickel dual catalysis using chiral biimidazoline (BiIm) ligand is reported to access 1,1‐diaryl alkanes and aryl allylic compounds with good yield as well as stereo‐ and enantioselectivities. This protocol uses more commercially available and less expensive C(sp2)‐Br as the electrophile coupling partner. A primary result using alkenyl chloride and alkyl chloride is also reported. Various functional groups are tolerated and the applications of this method are investigated by late‐stage functionalization and gram‐scale reaction.
Changes in biodiversity – the influence of climate change on the biological diversity of our earth
Authors: Fischer Sarah Christin , Heimann Rebekka 
Published: December 2021

AbstractIn diesem Beitrag wird ein fächerübergreifendes Konzept zum Thema Klimawandel und Biodiversität dargestellt, wobei besonders die Fächer Chemie, Biologie und Physik einbezogen werden. Sein Ziel ist die Förderung von Naturverbundenheit und besonders von Umweltwissen, was beides nachweislich die Umwelthandlungskompetenz beeinflusst. Den Schülerinnen und Schülern soll im Konzept die Bedeutung von Biodiversität im Kontext des Klimawandels bewusstwerden. Dabei wird das notwendige chemische Hintergrundwissen erarbeitet und anhand eines neuen Zusammenhangs gefestigt.
Immunoreactive distribution of gonadotropin‐inhibitory hormone precursor, RFRP, in a temperate bat species (Eptesicus fuscus)
Authors: Alonge Mattina M. , Greville Lucas J. S. , Faure Paul A. , Bentley George E. 
Published: December 2021

AbstractGonadotropin‐inhibitory hormone (GnIH, also known RFRP‐3 in mammals) is an important regulator of the hypothalamic–pituitary–gonadal axis and downstream reproductive physiology. Substantial species differences exist in the localization of cell bodies producing RFRP‐3 and patterns of fiber immunoreactivity in the brain, raising the question of functional differences. Many temperate bat species exhibit unusual annual reproductive patterns. Male bats upregulate spermatogenesis in late spring which is asynchronous with periods of mating in the fall, while females have the physiological capacity to delay their reproductive investment over winter via sperm storage or delayed ovulation/fertilization. Neuroendocrine mechanisms regulating reproductive timing in male and female bats are not well‐studied. We provide the first description of RFRP—precursor peptide of GnIH —expression and localization in the brain of any bat using a widespread temperate species (Eptesicus fuscus, big brown bat) as a model. RFRP mRNA expression was detected in the hypothalamus, testes, and ovaries of big brown bats. Cellular RFRP‐immunoreactivity was observed within the periventricular nuclei, dorsomedial nucleus of the hypothalamus, arcuate nucleus (Arc), and median eminence (ME). As in other vertebrates, RFRP fiber immunoreactivity was widespread, with the greatest density observed in the hypothalamus, preoptic area, Arc, ME, midbrain, and thalamic nuclei. Putative interactions between RFRP‐ir fibers and gonadotropin‐releasing hormone (GnRH) cell bodies were observed in 16% of GnRH‐immunoreactive cells, suggesting direct regulation of GnRH via RFRP signaling. This characterization of RFRP distribution contributes to a deeper understanding of bat neuroendocrinology, which serves as foundation for manipulative approaches examining changes in reproductive neuropeptide signaling in response to environmental and physiological challenges within, and among, bat species.
Association rule mining based fuzzy manta ray foraging optimization algorithm for frequent itemset generation from social media
Authors: Lakshmi N. , Krishnamurthy M. 
Published: December 2021

AbstractNowadays, the concept of data mining is employed widely and created a great deal of attention due to its fast arrival. Numerous approaches to frequent itemsets and association rule mining (ARM) are exemplified in recent years, but still, the performances based on scalability and processing time are considered as a major drawback that results in obtaining the solutions with very poor quality. To overcome such shortcomings, this article proposes three significant phases, namely, the data pre‐processing phase, data pre‐processing, frequent itemset mining, and ARM. In data pre‐processing phase, the collected twitter datasets are pre‐processed to eliminate redundant data and convert them into an appropriate format for further mining. In the frequent itemset mining phase, an Apriori algorithm is employed for the exact mining of frequent itemsets. The ARM phase utilizes the fuzzy manta ray foraging (FMRF) optimization algorithm that involves the generation of association rules from the huge itemsets thereby achieving minimum confidence and minimum support value. Here, the recent tweets regarding Covid‐19, trump2020, joebiden, draintheswamp, and Godzilla are the datasets collected from the Twitter web link. The experimental analysis and the comparative performances are performed for various simulation measures and the results reveal that the proposed approach provides effective performances when compared with various other existing approaches.
An efficient malicious webpage static detection framework based on optimized Bayesian and hybrid machine learning
Authors: Yang Fan , Zhu Chaoqun , Xu Heng , Qian Yongfeng , Song Jun 
Published: December 2021

SummaryMalicious webpage detection is a crucial work in both theory and practical environment. In practical applications, static detection methods are usually regarded as a priority choice, which can quickly detect unknown malicious web pages and avoid a costly in‐depth analysis. However, existing solution of static detection typically has the following problems. For example, a single static detection may lead to a higher false positive rate, and the integrated detection usually has a lower detection efficiency. In this article, we propose an efficient webpage static detection framework, especially considering both the detection efficiency and the detection accuracy. Then, on the basis of the extended feature sets from URL, HTML, and JavaScript, we introduce an optimized naive Bayesian algorithm, in which a novel amplification factor strategy is proposed. Finally, a webpage threat assessment model oriented to general machine learning is presented to achieve the refined detection. Three main properties are provided: high detection efficiency, high detection accuracy, and better applicability. Furthermore, the comprehensive experimental results and comparative analysis is given to show the advantages of the proposed framework.
Sex differences in refeeding among hospitalized adolescents and young adults with eating disorders
Authors: Nagata Jason M. , Bojorquez‐Ramirez Paola , Nguyen Anthony , Ganson Kyle T. , Machen Vanessa I. , Cattle Chloe J. , Buckelew Sara M. , Garber Andrea K. 
Published: December 2021

AbstractObjectiveTo determine sex differences in refeeding (i.e., short‐term nutritional rehabilitation) outcomes among hospitalized adolescents and young adults with eating disorders.MethodsWe retrospectively reviewed electronic medical records of 601 patients aged 9–25 years admitted to the University of California, San Francisco Eating Disorders Program for medical and nutritional management between May 2012 and August 2020. Descriptive statistics, crude, and adjusted linear regression models were used to assess the association between sex and nutritional outcomes and predictors of length of stay.ResultsA total of 588 adolescents and young adults met eligibility criteria (16% male, mean [SD] age 15.96  [2.75], 71.6% anorexia nervosa, admission percent median body mass index [%mBMI] 87.1 ± 14.1). In unadjusted comparisons, there were no significant sex differences in prescribed kilocalories (kcal) per day at admission (2013 vs. 1980, p = .188); however, males had higher estimated energy requirements (EER, kcal) (3,694 vs. 2,925, p < .001). In linear regression models adjusting for potential confounders, male sex was associated with higher prescribed kcals at discharge (B = 835 kcal, p < .001), greater weight change (B = 0.47 kg, p = .021), and longer length of stay (B = 1.94 days, p = .001) than females. Older age, lower admission weight, lower prescribed kcal at admission, higher EER, and lower heart rate at admission were factors associated with longer length of stay in a linear regression model.DiscussionThese findings support the development of individualized approaches for males with eating disorders to improve quality of care and health care efficiency among an underserved population.