bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poloxamer 188 (P188), A Potential Polymeric Protective Agent for Central
Nervous System Disorders: A Systematic Review
Authors: Chen Win Ning , Shaikh Mohd Farooq , Bhuvanendran Saatheeyavaane , Date Abhijit , Ansari Mohammad Tahir , Radhakrishnan Ammu Kutty , Othman Iekhsan 
Published: June 2021

:
Poloxamer 188 (P188) is an FDA-approved biocompatible block copolymer composed of
repeating units of Poly(Ethylene Oxide) (PEO) and poly(propylene oxide) (PPO). Due to its
amphiphilic nature and high Hydrophile-Lipophile Balance (HLB) value of 29, P188 is used as a
stabilizer/emulsifier in many cosmetics and pharmaceutical preparations. While the applications of
P188 as an excipient are widely explored, the data on the pharmacological activity of P188 are
scarce. Notably, the neuroprotective potential of P188 has gained a lot of interest. Therefore, this
systematic review is aimed at summarizing evidence of neuroprotective potential of P188 in CNS
disorders. The PRISMA model was used, and five databases (Google Scholar, Scopus, Wiley
Online Library, ScienceDirect, and PubMed) were searched with relevant keywords. The search
resulted in 11 articles, which met the inclusion criteria. These articles described the protective
effects of P188 on traumatic brain injury or mechanical injury in cells, neurotoxicity, Parkinson’s
disease, Amyotrophic lateral sclerosis (ALS), and ischemia/ reperfusion injury from stroke. All the
articles were original research in experimental or pre-clinical stages using animal models or in vitro
systems. The reported activities demonstrated the potential of P188 as a neuroprotective agent in
improving CNS conditions such as neurodegeneration.
Evaluation Framework for Successful Artificial Intelligence–Enabled Clinical Decision Support Systems: Mixed Methods Study
Authors: Ji Mengting , Genchev Georgi Z , Huang Hengye , Xu Ting , Lu Hui , Yu Guangjun 
Published: June 2021

BackgroundClinical decision support systems are designed to utilize medical data, knowledge, and analysis engines and to generate patient-specific assessments or recommendations to health professionals in order to assist decision making. Artificial intelligence–enabled clinical decision support systems aid the decision-making process through an intelligent component. Well-defined evaluation methods are essential to ensure the seamless integration and contribution of these systems to clinical practice.ObjectiveThe purpose of this study was to develop and validate a measurement instrument and test the interrelationships of evaluation variables for an artificial intelligence–enabled clinical decision support system evaluation framework.MethodsAn artificial intelligence–enabled clinical decision support system evaluation framework consisting of 6 variables was developed. A Delphi process was conducted to develop the measurement instrument items. Cognitive interviews and pretesting were performed to refine the questions. Web-based survey response data were analyzed to remove irrelevant questions from the measurement instrument, to test dimensional structure, and to assess reliability and validity. The interrelationships of relevant variables were tested and verified using path analysis, and a 28-item measurement instrument was developed. Measurement instrument survey responses were collected from 156 respondents.ResultsThe Cronbach α of the measurement instrument was 0.963, and its content validity was 0.943. Values of average variance extracted ranged from 0.582 to 0.756, and values of the heterotrait-monotrait ratio ranged from 0.376 to 0.896. The final model had a good fit (χ262=36.984; P=.08; comparative fit index 0.991; goodness-of-fit index 0.957; root mean square error of approximation 0.052; standardized root mean square residual 0.028). Variables in the final model accounted for 89% of the variance in the user acceptance dimension.ConclusionsUser acceptance is the central dimension of artificial intelligence–enabled clinical decision support system success. Acceptance was directly influenced by perceived ease of use, information quality, service quality, and perceived benefit. Acceptance was also indirectly influenced by system quality and information quality through perceived ease of use. User acceptance and perceived benefit were interrelated.
Public Awareness and Utilization of 937-Telephone Health Services in the Kingdom of Saudi Arabia Before and During the COVID-19 Pandemic: Longitudinal Study
Authors: Al-Rayes Saja A , Alumran Arwa , Aljabri Duaa , Aljaffary Afnan , Aldoukhi Ethar , Alahmedalyousif Zainab , Al Madani Reem 
Published: June 2021

Background
Telehealth plays a key role in supporting health care systems and influencing methods of health care delivery. Government laws and medical operating protocols have been largely modified to provide remote care to reduce social contact and ensure a safer patient environment. In the Kingdom of Saudi Arabia (KSA), the Ministry of Health (MOH) introduced several forms of telemedicine as alternatives to face-to-face consultations in clinical settings.

Objective
This study aimed to assess the awareness and utilization of telehealth services before and during the COVID-19 outbreak in the KSA.

Methods
In this longitudinal study, we compared the awareness and utilization of 937-telephone health services (ie, a toll-free telephone service to provide medical and administrative health care services at any time for the population) before and during the COVID-19 outbreak in the KSA. Using a convenience sampling technique, a validated web-based questionnaire was distributed on social media platforms (Facebook, Twitter, and WhatsApp) at 2 timepoints: before (February 2019) and during (May 2020) the COVID-19 pandemic.

Results
The study sample comprised a total of 1961 participants who completed the questionnaire before (n=1303, 66%) and during (n=658, 33%) the COVID-19 pandemic. Both awareness (before=46% vs during=78%) and utilization (before=42% vs during=48%) of the 937-telephone health services increased significantly during the pandemic (P<.001). No significant association of the awareness or utilization of 937-telephone health services before and during the COVID-19 pandemic was found with respect to the participants’ age, education level, having children, or having any chronic disease.

Conclusions
Our findings indicate significant increases in the awareness and utilization of 937-telephone health services during the early days of the COVID-19 pandemic, suggesting an increase in public acceptance of the service and providing evidence of an equitable telemedicine service for the population. Further studies are needed to provide a deeper understanding of the barriers and facilitators to the use of 937-telephone health services for different groups of the population.
Digital Technologies for Monitoring and Improving Treatment Adherence in Children and Adolescents With Asthma: Scoping Review of Randomized Controlled Trials
Authors: Milne-Ives Madison , Lam Ching , Meinert Edward 
Published: June 2021

Background
Inadequate pediatric asthma care has resulted in potentially avoidable unplanned hospital admissions and morbidity. A wide variety of digital technologies have been developed to monitor and support treatment adherence in children and adolescents with asthma. However, existing reviews need to be updated and expanded to provide an overview of the current state of research on these technologies and how they are being integrated into existing health care services and care pathways.

Objective
This study aims to provide an overview of the current research landscape and knowledge gaps regarding the use of digital technologies to support the care of children and adolescents with asthma.

Methods
This study was structured according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) and Population, Intervention, Comparator, Outcome, and Study frameworks. Five databases (PubMed, the Cochrane Central Register of Controlled Trials, Web of Science, Embase, and PsycINFO) were systematically searched for studies published in English from 2014 onward. Two reviewers independently screened the references and selected studies for inclusion based on the eligibility criteria. Data were systematically extracted per research question, which were synthesized in a descriptive analysis.

Results
A wide variety of study characteristics, including the number and age of participants, study duration, and type of digital intervention, were identified. There was mixed evidence for the effectiveness of the interventions. Of the 10 studies that evaluated treatment adherence, 7 (70%) found improvements, but the evidence was inconsistent for asthma control (6/9, 67% of studies reported improvement or maintenance, but only 1 was significantly different between groups) and health outcome variables (5/9, 56% of studies found no evidence of effectiveness). The 6 studies that examined patient perceptions and assessments of acceptability and usability generally had positive findings.

Conclusions
A wide range of digital interventions are being developed and evaluated to support the monitoring and treatment adherence of children and adolescents with asthma. Meta-analyses are inhibited by the use of samples with a variety of overlapping age ranges; a theoretical framework for evaluating specific age groups would aid comparison between studies. Most studies found significant evidence for improved adherence to treatment or medications, but there was mixed evidence of the impact of the digital interventions on asthma control and other health outcomes. There are gaps in the literature relating to cost-effectiveness and integration with existing clinical care pathways. This study will be necessary to determine which digital interventions for children and young people with asthma are worth supporting and adopting in the clinical care pathways.
Cenas da precariedade de ontem e de hoje | Scenes of the precariousness of yesterday and today
Authors: Amorim José Edilson 
Published: June 2021

ResumoA partir de uma crônica de Bráulio Tavares, este artigo reflete sobre cenas da precariedade de ontem e de hoje. A primeira cena está em Lima Barreto, em Recordações do escrivão Isaías Caminha, ao referir a Revolta da Vacina no Rio de Janeiro do século XX, comparada às manifestações de 2013 e 2014 no país; a segunda é a espetacularização da mídia sobre as manifestações de rua em 2013 e 2014, e sobre o processo de impedimento do mandato presidencial de Dilma Rousseff em 2015; a terceira é uma cena da vida cotidiana de uma moça de Brasília em outubro de 2014. As três situações revelam o mundo da classe trabalhadora e seu desamparo em meio ao espetáculo midiático.Palavras-chave: Trabalho. Mídia. Política. Espetáculo. AbstractFrom a chronicle by Bráulio Tavares, this paper reflects about scenes of the precariousness of yesterday and today. The first scene is in Lima Barreto’s novel Recordações do escrivão Isaías Caminha (Memories of the scrivener Isaías Caminha), when referring to the Vaccine Revolt in the Rio de Janeiro of the 20th century, compared to the manifestations of 2013 and 2014 in Brazil; the second is about the media spectacularization of the street manifestations between 2013 e 2014 in Brazil, and also on Dilma Rousseff's impeachment process in 2015; the third one is from the everyday life of a girl from Brasília in October of 2014. All those three situations reveal the world of the working class and its helplessness in the face of the media spectacularization.Keywords: Work. Media. Politics. Spectacle.
Long-term Predictions of Incident Coronary Artery Calcium to 85 Years of Age for Asymptomatic Individuals With and Without Type 2 Diabetes
Authors: Ferket Bart S. , Hunink M.G. Myriam , Masharani Umesh , Max Wendy , Yeboah Joseph , Fleischmann Kirsten E. 
Published: June 2021

OBJECTIVE
To examine the utility of repeated computed tomography (CT) coronary artery calcium (CAC) testing, we assessed risks of detectable CAC and its cardiovascular consequences in individuals with and without type 2 diabetes ages 45–85 years.

RESEARCH DESIGN AND METHODS
We included 5,836 individuals (618 with type 2 diabetes, 2,972 without baseline CAC) from the Multi-Ethnic Study of Atherosclerosis. With logistic and Cox regression we evaluated the impact of type 2 diabetes, diabetes treatment duration, and other predictors on prevalent and incident CAC. We used time-dependent Cox modeling of follow-up data (median 15.9 years) for two repeat CT exams and cardiovascular events to assess the association of CAC at follow-up CT with cardiovascular events.

RESULTS
For 45 year olds with type 2 diabetes, the likelihood of CAC at baseline was 23% vs. 17% for those without. Median age at incident CAC was 52.2 vs. 62.3 years for those with and without diabetes, respectively. Each 5 years of diabetes treatment increased the odds and hazard rate of CAC by 19% (95% CI 8–33) and 22% (95% CI 6–41). Male sex, White ethnicity/race, hypertension, hypercholesterolemia, obesity, and low serum creatinine also increased CAC. CAC at follow-up CT independently increased coronary heart disease rates.

CONCLUSIONS
We estimated cumulative CAC incidence to age 85 years. Patients with type 2 diabetes develop CAC at a younger age than those without diabetes. Because incident CAC is associated with increased coronary heart disease risk, the value of periodic CAC-based risk assessment in type 2 diabetes should be evaluated.
The Students’ Use of Google Classroom in Learning English
Authors: Salam Urai 
Published: June 2021

This study investigates the students’ use of Google Classroom in English language learning. The data were derived from Likert Scale questionnaires including open-ended questions distributed to 119 English Education students. There were five aspects covered in the questionnaire: access to Google Classroom, perceived usefulness, communication and interaction, instructional delivery and students’ satisfaction. Meanwhile, open-ended inquired students’ real experiences. The result showed the mean score with the following distribution: 4,49 for easy access to GC, 3,93 for perceived usefulness, 3,63 for communication and interaction, 4,10 for instructional delivery, and 3,82 for students’ satisfaction. Some students shared their experiences in using Google Classroom. Some of them said that Google Classroom brought their courses to their face so that they can participate and continue work on their classes beyond the working hours. Even many of them still worked and uploaded their assignments till midnight. In spite of these positive findings, the study revealed that some students fell into serious addiction to social media technology.
Peningkatan Keterampilan Tata Rias dan Busana Pesta di Jorong Kapuak Koto Panjang Nagari Barulak Kecamatan Tanjung Baru Kabupaten Tanah Datar
Authors: Dewi Siska Miga , Fitria Reni 
Published: June 2021

Amanah I merupakan organisasi yang beranggotakan ibu-ibu yang ada di Jorong Kapuak Koto Panjang Nagari Barulak Kec. Tanjung Baru Kab. Tanah Datar. Program organisasi ini yaitu simpan pinjam antar anggota. Dengan program yang ada, ibu-ibu yang menjadi anggota, berkeinginan memiliki keterampilan yang dapat dijadikan dasar terampil sehingga bisa membuka suatu usaha dan nantinya dapat menambah in-come bagi keluarga mereka. Berbagai keterampilan yang dapat dilakukan oleh para ibu-ibu diprogramkan oleh organisasi ini untuk dilaksanakan pelatihannya. Dengan demikian melalui Program Kemitraan Masyarakat (PKM) yang ada pada instansi Perguruan Tinggi, SPP Amanah I Jorong Kapuak Koto Panjang Nagari Barulak Kec. Tanjung Baru Kab. Tanah Datar melakukan kerjasama dalam pelaksanaan pengabdian kepada masyarakat berupa pelatihan keterampilan tentang tata rias dan busana pesta. Pelatihan ini akan diikuti oleh anggota SPP Aminah I dengan jumlah diperkirakan 15 orang peserta. Tujuan dari program PKM ini adalah (1) memiliki wawasan kemampuan dan keterampilan tentang tata rias dan busana pesta, (2) meningkatkan mutu proses dan hasil, (3) menumbuh kembangkan kegiatan keterampilan dalam tata rias dan pemilihan busana pesta sehingga bermanfaat untuk diri sendiri dan orang lain, (4) memberi peluang untuk membuka usaha dan meningkatkan usahanya di bidang tata rias dan busana pesta sehingga menambahkan in come bagi keluarga. Target yang dicapai peserta adalah memperoleh informasi, penyuluhan, keterampilan, sehingga diharapkan peserta pelatihan membuka usaha di bidang tata rias dan busana pesta. Adapun hasil penilaian program PKM ini oleh peserta pelatihan, yaitu sangat setuju 60,2%, setuju 39,8%, dan kepuasan peserta pelatihan terhadap pelatihan yang dilakukan, yaitu 80,4% sangat setuju, 19,6% setuju.
APRENDIZAJES, GENEROS Y SEXUALIDADES: APORTES DESDE UNA PERSPECTVA DIALÓGICA EN EL ESTUDIO DE LOS FENÉMENOS PSICO-SOCIALES
Authors: Pievi Néstor Ricerdo 
Published: June 2021

<p>El presente artículo se propone desarrollar un marco referencial interdisciplinar en el abordaje de las problemáticas relacionadas con géneros y sexualidades en los procesos de aprendizaje. Para ello se ha tomado en cuenta la perspectiva dialógica de Bajtin (1981, 1986), la Teoría de las Representaciones Sociales (Jodelet, 2002, 2006, 2008) y los aportes de los estudios sobre géneros y sexualidades (Butler, 2007; Crawford y Chaffin, 1997; Segato 2018), En las prácticas discursivas que se desarrollan en la cotidianeidad de los contextos educativos, sean estos formales, no-formales e informales, se definen configuraciones diversas en torno a géneros y sexualidades. En estas prácticas entran en juego sentidos y significados que están ligados a los escenarios históricos, culturales e institucionales donde los sujetos desarrollan y han desarrollado sus acciones comunicativas. En esta línea, la perspectiva dialógica de Bajtin (1981, 1986) nos remite a la identificación y análisis de las voces presentes en las narrativas de los sujetos posibilitando la comprensión de los enunciados que forman parte de tales acciones. Consideramos que la complejidad de la problemática educativa en el estudio de los fenómenos psico-sociales (Kornblit, 2014; Moreno, 2010; Morgade, 2001, 2008, 2016; Pievi 2017; Seidmann et alt, 2012) nos plantea la necesidad de un trabajo interdisciplinario y pluri-metodológico (Abric 1994; Apostolidis 2003 ; Jodelet 1989, Markova 2016) en el abordaje de las configuraciones construídas socio-culturalmente en torno a géneros y sexualidades.</p><p><strong>Palabras Claves</strong>: Aprendizajes, Géneros, Sexualidades, Dialogicidad.</p>
Cyberbullying Analysis on WhatsApp Messenger Using the National Institute of Justice (NIJ) Method
Authors: Putra I Putu Denny Indra , Suhartana I Ketut Gede 
Published: June 2021

Social media is no stranger to today's digital era. Many people prefer to use social media because of its simplicity and safety, This is what makes social media more popular than other services. However, because of its convenience and security, social media, especially WhatsApp Messenger, are vulnerable to crime, one of the most common is cyberbullying. For this reason, a mobile forensic investigation is required to find evidence related to cyberbullying. In this study, the National Institute of Justice (NIJ) method was used to investigate the WhatsApp Messenger platform used for cyberbullying. The NIJ method has 5 (five) stages to carry out the forensic process, namely Preparing, Collection, Examination, Analysis, and Reporting. This study also uses 3 assistance from software, namely MOBILedit Forensic, DB Browser for SQLite, and Odin3. This research is expected to be able to help solve the problem of cyberbullying and other crimes found on social media, especially WhatsApp Messenger.
A REVIEW OF PHYTOCHEMICAL PROPERTIES, ANTIBACTERIAL ACTIVITY, AND TOXICITY STUDY OF Averrhoa bilimbi LEAVES AND FRUIT
Authors: Leliqia Ni Putu Eka , Safitri Intan 
Published: June 2021

Background: Averrhoa bilimbi or starfruit is a plant that is commonly found in Indonesia. A. bilimbi is widely used as herbal therapy against various diseases, especially those caused by bacteria. Objective: This article is intended to provide information regarding the chemical content of A. bilimbi, its antibacterial potential, and its safety level. Methods: The preparation of this article used a systematic literature review method of articles that have been published in both national and international scientific journal. Result: Leave and fruit of A. bilimbi is known to contain several classes of primary and secondary metabolites, namely carbohydrates, proteins, fats, flavonoids, alkaloids, glycosides, saponins, tannins, triterpenoids, and steroids. A. bilimbi also contains several macros and micro minerals including calcium (Ca), magnesium (Mg), and zinc (Zn). A. bilimbi could inhibit the growth of various Gram-positive and negative bacteria which have been proven through in vitro testing with diffusion and dilution methods. Based on the acute toxicity study, it was found that 80% ethanol extract of A. bilimbi fruit had an LD50 value of above 5.000 mg/kg BW so that it is practically non-toxic. Based on sub-chronic toxicity of A. bilimbi up to a dose of 500 mg/kg BW there was no death in the test animals and shows a toxic effect. Conclusion: The leaves and fruit of A. bilimbi have antibacterial activities. The compounds contained in A. bilimbi are thought to have a role in its antibacterial activity. Based on several toxicity studies, the ethanol extract of A. bilimbi has been proven safe to use.
Keywords: Averrhoa bilimbi, Starfruit, Antibacterial, Chemical Properties, Toxicity.
SEQUÊNCIA DE ENSINO-APRENDIZAGEM EM FARMÁCIA: METODOLOGIA ATIVA COM O TEMA PERFUME
Authors: Tescarollo Iara Lucia 
Published: June 2021

No atual contexto social, pelo avanço das novas tecnologias e pela percepção do mundo vivo como uma rede de relações dinâmicas e em constante transformação tem-se discutido a necessidade de urgentes mudanças nas instituições de ensino superior. Nesse contexto, algumas instituições brasileiras converteram o modelo de ensino passivo, centrado no professor, para um ensino estruturado numa matriz curricular centrada no aluno. Este trabalho propôs a utilização de metodologia ativa baseada nas Sequências de Ensino-Aprendizagem para desenvolver o tema perfume, conteúdo oferecido na disciplina cosmetologia do Curso de Farmácia da Universidade São Francisco. Como recurso didático foi utilizado o modelo 5E que envolve cinco etapas: engajamento; exploração; explicação; elaboração; e avaliação (do inglês evaluation). Ao final do processo os alunos avaliaram a metodologia meio de questionário com escala Likert. A partir dos resultados obtidos calculou-se o Ranking Médio para avaliar o nível de satisfação dos estudantes e valor de alfa de Cronbach para verificar se o instrumento de medição apresentou confiabilidade no espaço onde foi aplicado. Como resultado ficou evidente que a utilização de metodologias ativas na disciplina de cosmetologia permitiu autonomia e motivação por parte dos alunos. Foi possível observar maior compreensão sobre o tema, maior retenção de conhecimentos. Metodologias ativas envolvendo SEA e 5E se apresentaram como um recurso metodológico de grande importância para o planejamento de estratégias de ensino sobretudo no curso de farmácia.