bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing response, remission, and treatment resistance in patients with obsessive–compulsive disorder with and without tic disorders: results from a multicenter study
Authors: Benatti Beatrice , Girone Nicolaja , Conti Dario , Cafaro Rita , Viganò Caterina , Briguglio Matteo , Marazziti Donatella , Mucci Federico , Gambini Orsola , Demartini Benedetta , Tundo Antonio , Necci Roberta , De Berardis Domenico , Galentino Roberta , De Michele Sara , Balestrino Roberta , Albert Umberto , Rigardetto Sylvia , Maina Giuseppe , Grassi Giacomo , Pallanti Stefano , Amerio Andrea , Aguglia Andrea , Prestia Davide , Amore Mario , Priori Alberto , Servello Domenico , Porta Mauro , Dell’Osso Bernardo 
Published: September 2021

AbstractBackgroundHighlighting the relationship between obsessive–compulsive disorder (OCD) and tic disorder (TD), two highly disabling, comorbid, and difficult-to-treat conditions, Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) acknowledged a new “tic-related” specifier for OCD, ie, obsessive–compulsive tic-related disorder (OCTD). As patients with OCTD may frequently show poor treatment response, the aim of this multicenter study was to investigate rates and clinical correlates of response, remission, and treatment resistance in a large multicenter sample of OCD patients with versus without tics.MethodsA sample of 398 patients with a DSM-5 diagnosis of OCD with and without comorbid TD was assessed from 10 different psychiatric departments across Italy. For the purpose of the study, treatment response profiles in the whole sample were analyzed comparing the rates of response, remission, and treatment-resistance as well as related clinical features. Multivariate logistic regressions were performed to identify possible factors associated with treatment response.ResultsThe remission group was associated with later ages of onset of TD and OCD. Moreover, significantly higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts emerged in the treatment-resistant group, with larger degrees of perceived worsened quality of life and family involvement.ConclusionsAlthough remission was associated with later ages of OCD and TD onset, specific clinical factors, such as early onset and presence of psychiatric comorbidities and concomitant TD, predicted a worse treatment response with a significant impairment in quality of life for both patients and their caregivers, suggesting a worse profile of treatment response for patients with OCTD.
Interspecific hybridization as a way of resistance transfer against viruses in okra: Hindrances and way forward
Authors: Patel Bhumika N. , Hegde Gopal Krishna , Manu T. G. 
Published: September 2021

AbstractOkra (Abelmoschus esculentus L. Moench) is considered as a treasure house of nutrients and it is one of the major vegetables widely spread all over tropical, subtropical and warm temperate regions of the world. Yellow vein mosaic virus (YVMV) and enation leaf curl virus are the most destructive diseases of okra as they affect both crop growth and yield. Due to the frequent breakdown of resistance and lack of a stable source of resistance in the cultivated species, interspecific hybridization is considered as a reliable approach for durable resistance. Cultivated species from The United States Department of Agriculture and wild accessions from The National Bureau of Plant Genetic Resources were screened at YVMV hotspot (Guntur, Andhra Pradesh) to identify the potential donors for disease resistance. Accessions IC141032 and IC141012 were found to be free from both viruses and categorized as resistant lines. Interspecific hybridization between A. tetraphyllus and A. esculentus revealed a high crossability index of around 80% when A. esculentus was utilized as a female parent. The bottleneck of hybrid sterility was partially overcome by the colchicine treatment of interspecific F1 hybrids. Good seed set was observed when raw colchiploids were backcrossed to the recurrent parent.
Predicting Alcohol Dependence Symptoms by Young Adulthood: A Co-Twin Comparisons Study
Authors: Stephenson Mallory , Barr Peter , Aliev Fazil , Ksinan Albert , Latvala Antti , Vuoksimaa Eero , Viken Richard , Rose Richard J. , Kaprio Jaakko , Dick Danielle , Salvatore Jessica E. 
Published: September 2021

AbstractCo-twin comparisons address familial confounding by controlling for genetic and environmental influences that twin siblings share. We applied the co-twin comparison design to investigate associations of adolescent factors with alcohol dependence (AD) symptoms. Participants were 1286 individuals (581 complete twin pairs; 42% monozygotic; and 54% female) from the FinnTwin12 study. Predictors included adolescent academic achievement, substance use, externalizing problems, internalizing problems, executive functioning, peer environment, physical health, relationship with parents, alcohol expectancies, life events, and pubertal development. The outcome was lifetime AD clinical criterion count, as measured in young adulthood. We examined associations of each adolescent domain with AD symptoms in individual-level and co-twin comparison analyses. In individual-level analyses, adolescents with higher levels of substance use, teacher-reported externalizing problems at age 12, externalizing problems at age 14, self- and co-twin-reported internalizing problems, peer deviance, and perceived difficulty of life events reported more symptoms of AD in young adulthood (ps < .044). Conversely, individuals with higher academic achievement, social adjustment, self-rated health, and parent–child relationship quality met fewer AD clinical criteria (ps < .024). Associations between adolescent substance use, teacher-reported externalizing problems, co-twin-reported internalizing problems, peer deviance, self-rated health, and AD symptoms were of a similar magnitude in co-twin comparisons. We replicated many well-known adolescent correlates of later alcohol problems, including academic achievement, substance use, externalizing and internalizing problems, self-rated health, and features of the peer environment and parent–child relationship. Furthermore, we demonstrate the utility of co-twin comparisons for understanding pathways to AD. Effect sizes corresponding to the associations between adolescent substance use, teacher-reported externalizing problems, co-twin-reported internalizing problems, peer deviance, and self-rated health were not significantly attenuated (p value threshold = .05) after controlling for genetic and environmental influences that twin siblings share, highlighting these factors as candidates for further research.
Genesis Locations of the Costliest Atmospheric Rivers Impacting the Western United States
Authors: Prince Hamish D. , Gibson Peter B. , DeFlorio Michael J. , Corringham Thomas W. , Cobb Alison , Guan Bin , Ralph F. Martin , Waliser Duane E. 
Published: September 2021

AbstractAtmospheric rivers (ARs) are responsible for the vast majority (∼88%) of flood damage in the Western U.S., an annual average of USD$1.1 billion. Here, using historical flood insurance data, we investigate the genesis characteristics of damaging ARs in the Western U.S.. ARs exceeding USD$20 million in damage (90th percentile), are shown to travel further across the Pacific Ocean, with median genesis locations 8°–27° further westward compared to typical ARs. Identifying regions of preferential genesis of damaging ARs elicit important implications for AR observation campaigns, highlighting distant regions not currently considered for AR reconnaissance. The genesis of damaging ARs is associated with elevated upper‐level zonal wind speeds along with deeper cyclonic anomalies, most pronounced for Washington and Oregon ARs. Linking AR dynamics and lifecycle characteristics to economic damage provides an opportunity for impact‐based forecasting of ARs prior to landfall, supporting efforts to mitigate extreme flood damages.
Global Frequency and Geographical Distribution of Nighttime Streamer Corona Discharges (BLUEs) in Thunderclouds
Authors: Soler S. , Gordillo‐Vázquez F. J. , Pérez‐Invernón F. J. , Luque A. , Li D. , Neubert T. , Chanrion O. , Reglero V. , Navarro‐González J. , Østgaard N. 
Published: September 2021

AbstractBlue LUminous Events (BLUEs) are transient corona discharges occurring in thunderclouds and characterized by strong 337.0 nm light flashes with absent (or weak) 777.4 nm component. We present the first nighttime climatology of BLUEs as detected by the Modular Multispectral Imaging Array of the Atmosphere‐Space Interaction Monitor showing their worldwide geographical and seasonal distribution. A total (land and ocean) of 11 BLUEs occur around the globe every second at local midnight and the average BLUE land/sea ratio is 7:4. The northwest region of Colombia shows an annual nighttime peak. Globally, BLUEs are maximized during the boreal summer‐autumn, contrary to lightning which is maximed in the boreal summer. The geographical distribution of nighttime BLUEs shows three main regions in, by order of importance, the Americas, Europe/Africa and Asia/Australia.
The Influence of Interdecadal Changes in Boreal Winter Teleconnections Around the 1980s on Planetary Waves and Stratospheric Sudden Warmings
Authors: Li Yuanpu , Wen Zhiping 
Published: September 2021

AbstractThis study investigated the influence of the interdecadal changes in the Pacific‐North America (PNA) and Western Pacific (WP) teleconnections on the planetary waves and stratospheric sudden warmings (SSWs), based on the National Center for Environmental Prediction reanalysis and Japanese 55‐year reanalysis. Before the 1980s, there were more negative PNA & negative WP combinations (−PNA&−WP), and after the 1980s, there were more +PNA&+WP. +PNA&−WP and −PNA&+WP had no significant interdecadal changes before and after the 1980s. The interdecadal changes in the teleconnection combinations may be related to the Pacific Decadal Oscillation (PDO). During +PNA&+WP (−PNA&−WP), the planetary waves with wavenumber 1 have the maximum (minimum) wave energy and propagating more (less) to the stratosphere, causing a greater (lesser) frequency of SSWs. Thus, the interdecadal changes in the teleconnection combinations are one of the important factors which could contribute to the possible increase in SSWs after the 1980s. Since there are no satellite observations on the stratosphere before 1979, there are still many uncertainties in the interdecadal changes in SSWs.
Substantial Stem Methane Emissions From Rainforest and Cacao Agroforest Partly Negate Soil Uptake in the Congo Basin
Authors: Iddris Najeeb A. , Corre Marife D. , van Straaten Oliver , Tchiofo Lontsi Rodine , Veldkamp Edzo 
Published: September 2021

AbstractMost stem CH4 emission investigations were conducted in wetland forests, and it remains unknown whether trees in tropical rainforests on heavily weathered soils are substantial contributors to ecosystem CH4 fluxes. Additionally, Africa remains the continent with the lowest numbers of published field studies on soil greenhouse gas fluxes. Over one year, we measured monthly stem and soil CH4 fluxes with forest conversion to traditional cacao agroforestry in the Congo Basin, Cameroon. All the measured trees emitted CH4 throughout the year. The annual total (soil + stem) CH4 fluxes were −2.62 ± 0.37 kg C ha−1 yr−1 from the forest and −3.23 ± 0.45 kg C ha−1 yr−1 for the cacao agroforestry, with stem CH4 emissions equating to 4%–21% of the soil sink in the forest, and 3%–27% of the soil sink in cacao agroforestry. 2% of our measured trees were “hot spots” of CH4 emission, with two orders of magnitude larger emissions than the remaining trees in our sites. Correlations of stem CH4 emissions and soil drivers suggest a potential belowground source of stem CH4 emissions, although this pathway may be working simultaneously with a within‐tree microbial CH4 source. Overall, forest conversion to traditional, mature cacao agroforestry did not affect stem and soil CH4 fluxes. Our results demonstrate that tropical trees on well‐drained, highly weathered soils represent potential CH4 emission pathways that have largely been ignored, and provides evidence that upland ecosystems may be weaker sinks of atmospheric CH4 than previously estimated.
Performance Characterization of ESA's Tropospheric Delay Calibration System for Advanced Radio Science Experiments
Authors: Lasagni Manghi Riccardo , Zannoni Marco , Tortora Paolo , Martellucci Antonio , De Vicente Javier , Villalvilla Jose , Mercolino Mattia , Maschwitz Gerrit , Rose Thomas 
Published: September 2021

AbstractMedia propagation noises are amongst the main error sources of radiometric observables for deep space missions, with fluctuations of the tropospheric excess path length representing a relevant contributor to the Doppler noise budget. Microwave radiometers currently represent the most accurate instruments for the estimation of the tropospheric delay and delay rate along a slant direction. A prototype of a tropospheric delay calibration system (TDCS), using a 14 channel Ka/V band microwave radiometer, has been developed under a European Space Agency contract and installed at the deep space ground station in Malargüe, Argentina, in February 2019. After its commissioning, the TDCS has been involved in an extensive testbed campaign by recording a total of 44 tracking passes of the Gaia spacecraft, which were used to perform an orbit determination analysis. This work presents the first statistical characterization of the end‐to‐end performance of the TDCS prototype in an operational scenario. The results show that using TDCS‐based calibrations instead of the standard GNSS‐based calibrations leads to a significant reduction of the residual Doppler noise and instability.
Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents
Authors: Komura Kazumasa , Inamoto Teruo , Tsujino Takuya , Matsui Yusuke , Konuma Tsuyoshi , Nishimura Kazuki , Uchimoto Taizo , Tsutsumi Takeshi , Matsunaga Tomohisa , Maenosono Ryoichi , Yoshikawa Yuki , Taniguchi Kohei , Tanaka Tomohito , Uehara Hirofumi , Hirata Koichi , Hirano Hajime , Nomi Hayahito , Hirose Yoshinobu , Ono Fumihito , Azuma Haruhito 
Published: September 2021

AbstractThere has been accumulating evidence for the clinical benefit of chemoradiation therapy (CRT), whereas mechanisms in CRT-recurrent clones derived from the primary tumor are still elusive. Herein, we identified an aberrant BUB1B/BUBR1 expression in CRT-recurrent clones in bladder cancer (BC) by comprehensive proteomic analysis. CRT-recurrent BC cells exhibited a cell-cycle-independent upregulation of BUB1B/BUBR1 expression rendering an enhanced DNA repair activity in response to DNA double-strand breaks (DSBs). With DNA repair analyses employing the CRISPR/cas9 system, we revealed that cells with aberrant BUB1B/BUBR1 expression dominantly exploit mutagenic nonhomologous end joining (NHEJ). We further found that phosphorylated ATM interacts with BUB1B/BUBR1 after ionizing radiation (IR) treatment, and the resistance to DSBs by increased BUB1B/BUBR1 depends on the functional ATM. In vivo, tumor growth of CRT-resistant T24R cells was abrogated by ATM inhibition using AZD0156. A dataset analysis identified FOXM1 as a putative BUB1B/BUBR1-targeting transcription factor causing its increased expression. These data collectively suggest a redundant role of BUB1B/BUBR1 underlying mutagenic NHEJ in an ATM-dependent manner, aside from the canonical activity of BUB1B/BUBR1 on the G2/M checkpoint, and offer novel clues to overcome CRT resistance.
First tracks of newborn straight-tusked elephants (Palaeoloxodon antiquus)
Authors: Neto de Carvalho Carlos , Belaústegui Zain , Toscano Antonio , Muñiz Fernando , Belo João , Galán Jose María , Gómez Paula , Cáceres Luis M. , Rodríguez-Vidal Joaquín , Cunha Pedro Proença , Cachão Mario , Ruiz Francisco , Ramirez-Cruzado Samuel , Giles-Guzmán Francisco , Finlayson Geraldine , Finlayson Stewart , Finlayson Clive 
Published: September 2021

AbstractTracks and trackways of newborns, calves and juveniles attributed to straight-tusked elephants were found in the MIS 5 site (Upper Pleistocene) known as the Matalascañas Trampled Surface (MTS) at Huelva, SW Spain. Evidence of a snapshot of social behaviour, especially parental care, can be determined from the concentration of elephant tracks and trackways, and especially from apparently contemporaneous converging trackways, of small juvenile and larger, presumably young adult female tracks. The size frequency of the tracks enabled us to infer body mass and age distribution of the animals that crossed the MTS. Comparisons of the MTS demographic frequency with the morphology of the fore- and hind limbs of extant and fossil proboscideans shed light into the reproductive ecology of the straight-tusked elephant, Palaeloxodon antiquus. The interdune pond habitat appeared to have been an important water and food resource for matriarchal herds of straight-tusked elephants and likely functioned as a reproductive habitat, with only the rare presence of adult and older males in the MTS. The preservation of this track record in across a paleosol surface, although heavily trampled by different animals, including Neanderthals, over a short time frame, permitted an exceptional view into short-term intraspecific trophic interactions occurring in the Last Interglacial coastal habitat. Therefore, it is hypothesized that Neanderthals visited MTS for hunting or scavenging on weakened or dead elephants, and more likely calves.
A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels
Authors: Alves Juliano , Engel Laurie , de Vasconcelos Cabral Renata , Rodrigues Eduardo L. , de Jesus Ribeiro Liane , Higa Luiza M. , da Costa Ferreira Júnior Orlando , Castiñeiras Terezinha Marta P. P. , de Carvalho Leitão Isabela , Tanuri Amilcar , Goueli Said A. , Zegzouti Hicham 
Published: September 2021

AbstractHere we describe a homogeneous bioluminescent immunoassay based on the interaction between Fc-tagged SARS-CoV-2 Spike RBD and human ACE2, and its detection by secondary antibodies labeled with NanoLuc luciferase fragments LgBit and SmBit. The assay utility for the discovery of novel inhibitors was demonstrated with a panel of anti-RBD antibodies, ACE2-derived miniproteins and soluble ACE2. Studying the effect of RBD mutations on ACE2 binding showed that the N501Y mutation increased RBD apparent affinity toward ACE2 tenfold that resulted in escaping inhibition by some anti-RBD antibodies. In contrast, while E484K mutation did not highly change the binding affinity, it still escaped antibody inhibition likely due to changes in the epitope recognized by the antibody. Also, neutralizing antibodies (NAbs) from COVID-19 positive samples from two distinct regions (USA and Brazil) were successfully detected and the results further suggest the persistence of NAbs for at least 6 months post symptom onset. Finally, sera from vaccinated individuals were tested for NAbs and showed varying neutralizing activity after first and second doses, suggesting the assay can be used to assess immunity of vaccinated populations. Our results demonstrate the broad utility and ease of use of this methodology both for drug discovery and clinical research applications.
Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood–brain barrier leakage
Authors: Runnova Anastasiya , Zhuravlev Maksim , Ukolov Rodion , Blokhina Inna , Dubrovski Alexander , Lezhnev Nikita , Sitnikova Evgeniya , Saranceva Elena , Kiselev Anton , Karavaev Anatoly , Selskii Anton , Semyachkina-Glushkovskaya Oxana , Penzel Thomas , Kurths Jurgen 
Published: September 2021

AbstractA new approach for detection oscillatory patterns and estimation of their dynamics based by a modified CWT skeleton method is presented. The method opens up additional perspectives for the analysis of subtle changes in the oscillatory activity of complex nonstationary signals. The method was applied to analyze unique experimental signals obtained in usual conditions and after the non-invasive increase in the blood–brain barrier (BBB) permeability in 10 male Wistar rats. The results of the wavelet-analysis of electrocorticography (ECoG) recorded in a normal physiological state and after an increase in the BBB permeability of animals demonstrate significant changes between these states during wakefulness of animals and an essential smoothing of these differences during sleep. Sleep is closely related to the processes of observed changes in the BBB permeability.
Oncogenic signaling inhibits c-FLIPL expression and its non-apoptotic function during ECM-detachment
Authors: Tsegaye Matyas Abel , He Jianping , McGeehan Kyle , Murphy Ireland M. , Nemera Mati , Schafer Zachary T. 
Published: September 2021

AbstractInhibition of programmed cell death pathways is frequently observed in cancer cells where it functions to facilitate tumor progression. However, some proteins involved in the regulation of cell death function dichotomously to both promote and inhibit cell death depending on the cellular context. As such, understanding how cell death proteins are regulated in a context-dependent fashion in cancer cells is of utmost importance. We have uncovered evidence that cellular FLICE-like Inhibitory Protein (c-FLIP), a well-known anti-apoptotic protein, is often downregulated in tumor tissue when compared to adjacent normal tissue. These data argue that c-FLIP may have activity distinct from its canonical role in antagonizing cell death. Interestingly, we have discovered that detachment from extracellular matrix (ECM) serves as a signal to elevate c-FLIP transcription and that oncogenic signaling blocks ECM-detachment-induced c-FLIP elevation. In addition, our data reveal that downregulation of c-FLIP promotes luminal filling in mammary acini and that c-FLIP overexpression in cancer cells inhibits colony formation in cells exposed to ECM-detachment. Taken together, our study reveals an unexpected, non-apoptotic role for c-FLIP during ECM-detachment and raises the possibility that c-FLIP may have context-dependent roles during tumorigenesis.