bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of iron polymaltose complex in treatment and prevention of iron deficiency anemia in children: a systematic review and meta-analysis
Authors: Mohd Rosli Ritzzaleena Rosli , Norhayati Mohd Noor , Ismail Shaiful Bahari 
Published: January 2021

Background
Iron deficiency anemia (IDA) is commonly treated with iron formulations. Despite the expanding acceptance of iron polymaltose complex (IPC) among clinicians, there is sparse and contradictory evidence regarding its efficacy in the management of IDA in children. This systematic review and meta-analysis aimed to assess the effectiveness of IPC in the treatment and prevention of IDA in children.

Methods
We searched the Cochrane Central Register of Controlled Trials, MEDLINE and Epistemonikos for all randomized control trials (RCTs) comparing oral IPC with standard oral iron supplementation for the treatment or prevention of IDA in children. We independently screened the titles and abstracts of identified trials before the full text of relevant trials was evaluated for eligibility. We then independently extracted data on the methods, interventions, outcomes, and risk of bias from the included trials. A random-effects model was used to estimate the risk ratios and mean differences with 95% confidence intervals.

Results
Eight trials comprising 493 randomized patients were included and analyzed using three comparison groups. The comparison group of which was used to evaluate IPC and ferrous sulphate (FS) for treatment of IDA showed that IPC is less effective in increasing Hb (MD −0.81, 95% CI −1.08 to −0.53; I2 = 48%, P < 0.001; six studies, 368 participants; high certainty of evidence), ferritin (MD −21.24, 95% CI −39.26 to −3.23, random-effects; I2 = 65%, P = 0.020; 3 studies, 183 participants; moderate certainty of evidence) and MCV levels (MD −3.20, 95% CI −5.35 to −1.05; P = 0.003; one study, 103 participants; low certainty of evidence). There was no difference in the occurrence of side effects between IPC and FS group (MD 0.78, 95% CI 0.47 to 1.31; I2 = 4%, P = 0.35; three studies, 274 participants; high certainty of evidence).

Conclusions
There was moderate to high certainty evidence that FS is superior to IPC with a clinically meaningful difference in improving the Hb and ferritin levels in the treatment of IDA in children. There was no difference in the occurrence of gastrointestinal side effects with high certainty evidence between the IPC and FS groups. The body of evidence did not allow a clear conclusion regarding the effectiveness of IPC with iron gluconate and iron bisglycinate in the prevention and treatment of IDA. The certainty of evidence was low. Adequately powered and high-quality trials with large sample sizes that assess both hematological and clinical outcomes are required.

PROSPERO registration number: CRD42019145020
The association between serum uric acid and diabetic complications in patients with type 2 diabetes mellitus by gender: a cross-sectional study
Authors: Hu Yimeng , Li Qinge , Min Rui , Deng Yingfeng , Xu Yancheng , Gao Ling 
Published: January 2021

BackgroundThe relationship between serum uric acid (SUA) and several diabetic complications or co-morbidities remains a matter of debate. The study aims to explore the association between SUA levels and the prevalence of non-alcoholic fatty liver disease (NAFLD), diabetic retinopathy (DR), diabetic nephropathy (DN) and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM).MethodsA total of 2,809 participants (1,784 males and 1,025 females) were included in this cross-sectional study. Clinical characteristics and the prevalence of each of the four diseases were analyzed based on gender-specific quartiles of SUA levels. The Pearson correlation analysis and linear-regression analysis were used to access the correlation between SUA levels and clinical characteristics. Furthermore, a binary logistic regression analysis was carried out to determine whether SUA was an independent risk factor for each of the four complications.ResultsSUA levels were positively correlated to BMI, BUN, Scr and TG, but negatively associated with eGFR, HDL, FBG, 2h-PG and HbA1c% for the patients with T2DM. The prevalence of NAFLD and DN, but not DR or DPN, were increased with SUA levels from the first to the fourth quartile. Binary logistic regression further disclosed that SUA was an independent risk factor for NAFLD (ORs Male = 1.002,∗P = 0.0013; ORs Female = 1.002,∗P = 0.015) and DN (ORs Male = 1.006,∗P < 0.001; ORs Female = 1.005,∗P < 0.001), but not for DR and DPN. After adjustment for the confounders, SUA levels were significantly associated with NAFLD within the 3rd (ORs = 1.829,P = 0.004) and 4th quartile (ORs = 2.064,P = 0.001) for women, but not independently associated with SUA for man. On the other hand, our results revealed increased prevalence of DN for SUA quartile 2 (ORs = 3.643,P = 0.039), quartile 3 (ORs = 3.967,P = 0.024) and quartile 4 (ORs = 9.133,P < 0.001) in men; however, SUA quartiles were significantly associated with DN only for quartile 4 (ORs = 4.083,P = 0.042) in womenConclusionFor patients with T2DM, elevated SUA concentration is an independent risk factor for the prevalence of NAFLD and DN after adjustment for other indicators, but not DR or DPN.
The effectiveness of incorporating metacognitive prompts in collaborative writing on academic English writing skills
Authors: Teng Mark Feng 
Published: January 2021

AbstractResearch shows that acquisition of writing skills can be supported by metacognitive strategy training. However, research on incorporating metacognitive guidance for collaborative writing is scarce. The current study explores the potential effectiveness of incorporating metacognitive prompts, that is, a form of metacognitive guidance, into collaborative writing on academic English writing skills. This study involves four instructional methods, that is, collaborative writing combined with embedded metacognitive guidance (COLL+META), metacognitive training without collaborative writing (META), collaborative writing without metacognitive training (COLL), and individual learning (CG). The dependent variables were students' four academic writing skills, that is, reproduction of text structure knowledge, application of text structure knowledge, reduction of text content, and abstract writing. Participants included 160 students who were learning English as a foreign language (EFL) at a university in mainland China. The participants in each condition received 16 weeks of treatment sessions. The results revealed the improvement from pre‐test to post‐test, supporting the main effects of each learning condition on the four academic writing skills. The results also showed that the COLL+META students demonstrated significantly higher scores in the four academic writing skills than students in the other conditions. This study underlines the importance of incorporating metacognitive strategies for collaborative writing in developing academic writing skills for university EFL students. This study also highlights the potential in applying educational psychology theories for English education.
Research ethics beyond the IRB: Selection bias and the direction of innovation in applied economics
Authors: Michler Jeffrey D. , Masters William A. , Josephson Anna 
Published: January 2021

AbstractPrinciples for ethical behavior in the context of research are codified into rules that may change over time to meet peoples’ needs in specific institutions, including universities and professional associations. This paper aims to spark discussion about a set of ethical choices beyond those addressed by an IRB or recent association policy statements. Our specific focus is topic selection and the role of researchers’ interests and incentives in determining the kinds of research that we do. Using the principle of induced innovation, we show how changing incentives can influence the direction of research effort and thereby affect the kinds of policies or technologies that are supported by available evidence. With this paper, we hope to generate discussion among applied economists about selection bias in research and how we can use insights from economics itself to guide topic selection.JEL CLASSIFICATIONA11; A14; B41; Q00
Incidence, predictors and outcomes of device‐related thrombus after left atrial appendage closure with the WATCHMAN device—Insights from the EWOLUTION real world registry
Authors: Sedaghat Alexander , Nickenig Georg , Schrickel Jan Wilko , Ince Hüseyin , Schmidt Boris , Protopopov Alexey V. , Betts Timothy R. , Gori Tommaso , Sievert Horst , Mazzone Patrizio , Grygier Marek , Wald Christof , Vireca Elisa , Allocco Dominic , Boersma Lucas V.A ,   the EWOLUTION study group
Published: January 2021

AbstractBackgroundIn this analysis of the EWOLUTION registry, we evaluated the incidence, relevance and predictors of device‐related thrombus in a large multi‐center real‐world cohort undergoing LAAc with the WATCHMAN device.Methods and ResultsWe analyzed the 835 patients who underwent percutaneous LAA closure with the WATCHMAN device in the EWOLUTION registry in whom at least one TEE follow up was performed. Patients were 74 ± 9 y/o and were at high risk for stroke and bleeding (CHA2DS2‐VASC‐Score 4.3 ± 1.7; HAS‐BLED‐Score 2.3 ± 1.2). Device‐related thrombus was detected in 4.1% (34/835) after a median of 54 days (IQR 42–111 days) with 91.2% (31/34) being detected within 3 months after the procedure or at the time of first TEE. Hereby DRT occurred irrespective of postprocedural anticoagulation. Patients with DRT more frequently had long‐standing, non‐paroxysmal atrial fibrillation (82.4 vs. 64.9%, p < .01), evidence of dense spontaneous echo contrast (26.5 vs. 11.9%, p = .03) and larger LAA diameters at the ostium (22.8 ± 3.5 vs. 21.1 ± 3.5 mm, p < .01) compared to patients without DRT. Left ventricular ejection fraction, device compression ratio and the incidence of renal dysfunction did not differ between the two groups. In a multivariate analysis, only non‐paroxysmal atrial fibrillation identified as an independent predictor of developing DRT. Specific treatment of DRT was initiated in 62% (21/34) of patients whereas resolution was confirmed in 86% (18/21) of cases. Overall, no significant differences in annual rates of stroke/TIA or systemic embolism were observed in patients with or without DRT (DRT 1.7 vs. No‐DRT 2.2%/year, p = .8).ConclusionsIn real‐world patients undergoing LAAc with the WATCHMAN device, DRT is rare. DRT was most frequently detected within the first 3 months after LAAc regardless of post‐procedural regimen and was not associated with an increased risk of stroke or SE. While long‐standing atrial fibrillation was the only independent factor associated with DRT, medical treatment of DRT resulted in a resolution of thrombi in most cases.
Waiting list eradication in secondary care psychology: Addressing a National Health Service blind spot
Authors: Iqbal Zaffer , Airey Nicola D. , Brown Sophie R. , Wright Nat M.J. , Miklova Deborah , Nielsen Victoria , Webb Kathryn , Sajjad Aamer 
Published: January 2021

AbstractObjectivesWaiting times for secondary care psychological therapy remain a ‘blind spot’ in serious mental illness (SMI) provision, and their reduction is a priority within the National Health Service (NHS) Five Year Forward View. The paper describes the eradication of waiting times within a community‐based NHS service and the effectiveness of strategies whilst examining help‐seeking behaviour, compliance and therapeutic need.MethodsAnalyses are reported for treatment compliance and therapeutic outcomes for 208 waiting‐list cohort individuals seen by the SMI psychology service over an 18‐month period between October 2014 and March 2016.ResultsNo significant clinical or demographic differentiation between individuals who successfully completed therapy compared to those who disengaged was observed. Despite an average 2.20‐year waiting time, this alone did not significantly impact engagement with psychological treatment and all psychological therapies provided led to a significant clinical improvement and no individuals who completed therapy required re‐referral at 12‐month follow‐up.ConclusionsIf imposed appropriately over a suitable time frame evidence‐based practice coupled with effective operationalization can result in efficient needs‐led psychological provision within SMI and secondary care. Potentially debilitating waiting times for service users and other referring professionals can be avoided, whilst psychology provision retains a flexible, formulation‐based and person‐centred approach.
Beneficial effect and mechanism of walnut oligopeptide on Lactobacillus plantarum Z7
Authors: Ding Ting , Li Yong 
Published: January 2021

AbstractPrebiotics can stimulate the growth and activity of probiotics and have a variety of physiological functions. However, the study of walnut oligopeptides as prebiotics to promote probiotics is rarely reported. Therefore, in order to explore the beneficial effect of walnut oligopeptide (WOPs) on Lactobacillus plantarum Z7, WOPs was added to the medium of L. plantarum Z7, and the utilization of WOPs, the effect of WOPs on the biofilm, extracellular polymeric substances, and bacterial death were explored. The results showed that the growth‐promoting effect was strengthened with the increasing concentrations of WOPs. The content of bacterial biofilm and EPS increased significantly, and the number of dead bacteria decreased. The beneficial effect of WOPs was probably because that it enhanced the secretion of biofilm which was regulated by bacterial quorum sensing system and promoted the ability of bacteria to resist the adverse environment, thus promoting the growth and reproduction of bacteria.
Heat transfer and irreversibility rate in MHD flow of a hybrid nanofluid with Newton boundary condition, slip flow, and nonlinear thermal radiation
Authors: Puttaswmay Venkatesh , Bijjanal Jayanna Gireesha , Doranalu Onkarappa Soumya 
Published: January 2021

AbstractThe magnetohydrodynamic flow of a water‐based hybrid nanoliquid through a vertical microchannel has been investigated in the presence of collective effects, such as volume fraction of nanoparticle, suction/injection, magnetic field, temperature‐dependent heat source, hydrodynamic slip, and convective boundary conditions. The current mathematical formulations have been worked out numerically by using the fourth‐ and fifth‐order Runge–Kutta–Fehlberg scheme. The physical aspects of variation in velocity, temperature, entropy generation, and Bejan number with considered governing parameters have been discussed via corresponding graphs. The obtained numerical results demonstrated that radiation parameter and nanoparticle volume fraction reduce the thermal energy of the hybrid nanofluid. Moreover, entropy generation diminishes with the Hartmann number and permeability parameter, whereas it enhances with the Grashof number and Biot number.
Serum soluble PD‐1 plays a role in predicting infection complications in patients with acute pancreatitis
Authors: Yu Xingxing , Pan Yu , Fei Qinglin , Lin Xianchao , Chen Zhijiang , Huang Heguang 
Published: January 2021

AbstractBackgroundMost of acute pancreatitis (AP) are mild and self‐limiting, however, 15%–20% of patients develop severe acute pancreatitis (SAP) or moderately acute pancreatitis (MSAP) with local or systemic complications. Infection complications (ICs) result in 40%–70% morbidity and high mortality rates among SAP and MSAP patients. It is more important to early recognize of ICs of MSAP or SAP. Several studies have indicated that serum soluble programmed cell death protein (sPD‐1) or programmed cell death 1 ligand (sPD‐L1) levels were higher in patients with severe sepsis than in healthy volunteers and have a predictive capacity for mortality. However, the role of serum sPD‐1/sPD‐L1 in AP remains unclear. This study aimed to investigate whether the ICs of AP patients is associated with their sPD‐1 and sPD‐L1 levels, which were determined via enzyme‐linked immunosorbent assay of peripheral blood samples from 63 MSAP and SAP patients and 30 healthy volunteers.ResultsThe serum sPD‐1 levels in AP patients on Days 1, 3, and 10 after onset were significantly increased in a time‐dependent manner compared with that in healthy volunteers. Moreover, the AP patients with ICs had significantly higher serum sPD‐1 levels than the AP without ICs. While serum sPD‐L1 levels in AP were similar to that in healthy volunteers. Besides, serum levels of sPD‐1/sPD‐L1 were negatively correlated with circulating lymphocytes. Univariate and multivariate regression analyses showed that the upregulated serum sPD‐1 level was an independent risk factor for ICs in AP. The area under the receiver operating characteristics curve indicated that combination with Acute Physiology and Chronic Health Evaluation II score and serum sPD‐1 level had a high accuracy in predicting ICs in AP.ConclusionSerum sPD‐1/sPD‐L1 may be involved in the immunosuppressive process in AP. Moreover, the serum sPD‐1 level may be an independent risk factor for predicting ICs in AP patients.
Clinical islet transplantation: Current progress and new frontiers
Authors: Marfil‐Garza Braulio A. , Shapiro Andrew Mark James , Kin Tatsuya 
Published: January 2021

AbstractIslet transplantation (IT) is now a robust treatment for selected patients with type 1 diabetes suffering from recurrent hypoglycemia and impaired awareness of hypoglycemia. A global soar of clinical islet transplant programs attests to the commitment of many institutions and researchers to advance IT as a potential cure for this devastating disease. However, many challenges limiting the widespread applicability of clinical IT remain. In this review, we will touch on the milestones in the history of IT and its path to clinical success, discuss the current challenges around IT, propose some possible solutions, and elaborate on the frontiers envisioned in the future of clinical IT.
Pomegranate peel attenuates dextran sulfate sodium‐induced lipid peroxidation in rat small intestine by enhancing the glutathione/glutathione disulfide redox potential
Authors: Al‐Gubory Kaïs H , Laher Ismail , Garrel Catherine 
Published: January 2021

AbstractBACKGROUNDThe peel of the pomegranate fruit is rich in polyphenols with antioxidant properties. We investigated the preventive effect of pomegranate peel (PP) powder against dextran sulfate sodium (DSS)‐induced lipid peroxidation in the small intestine of rats. Rats were allocated to four groups: CONT group, fed a standard rodent diet; DSS group, fed a standard rodent diet and treated with DSS; as well as PP1%+DSS and PP5%+DSS groups, fed a standard rodent diet supplemented with either 1% or 5% of PP powder and treated with DSS. Rats of the four groups consumed their diets for 25 days. Lipid peroxidation was determined by measuring malondialdehyde (MDA) concentrations in plasma and MDA contents in the small intestine and liver. Glutathione/glutathione disulfide (GSH/GSSG) redox status and antioxidant enzyme activities were determined in the small intestine and liver.RESULTSMDA content was higher (P < 0.001) in the small intestines of the DSS group compared to the CONT group. MDA content was reduced (P < 0.001) in the small intestines of the PP1%+DSS and PP5%+DSS groups compared to the DSS group. GSH contents and GSH/GSSG ratios were higher (P < 0.001) in the small intestines of the PP5%+DSS group compared to the CONT, DSS and PP1%+DSS groups.CONCLUSIONThe present study demonstrates that PP powder protects the small intestine against DSS‐induced lipid peroxidation by enhancing the GSH/GSSG redox potential. Powder of PP is a promising agricultural by‐product containing a mixture of bioactive polyphenols that can be used for the production of functional foods aimed at the prevention of oxidative stress‐induced small intestine pathogenesis. © 2021 Society of Chemical Industry
Stapled ACE2 peptidomimetics designed to target the SARS‐CoV‐2 spike protein do not prevent virus internalization
Authors: Morgan Danielle C. , Morris Caroline , Mahindra Amit , Blair Connor M. , Tejeda Gonzalo , Herbert Imogen , Turnbull Matthew L. , Lieber Gauthier , Willett Brian J. , Logan Nicola , Smith Brian , Tobin Andrew B. , Bhella David , Baillie George , Jamieson Andrew G. 
Published: January 2021

AbstractCOVID‐19 is caused by a novel coronavirus called severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). Virus cell entry is mediated through a protein‐protein interaction (PPI) between the SARS‐CoV‐2 spike protein and angiotensin‐converting enzyme 2 (ACE2). A series of stapled peptide ACE2 peptidomimetics based on the ACE2 interaction motif were designed to bind the coronavirus S‐protein RBD and inhibit binding to the human ACE2 receptor. The peptidomimetics were assessed for antiviral activity in an array of assays including a neutralization pseudovirus assay, immunofluorescence (IF) assay and in‐vitro fluorescence polarization (FP) assay. However, none of the peptidomimetics showed activity in these assays, suggesting that an enhanced binding interface is required to outcompete ACE2 for S‐protein RBD binding and prevent virus internalization.
Confinement on ℝ3 × 𝕊1 and double-string collapse
Authors: Bub Mathew W. , Poppitz Erich , Wong Samuel S.Y. 
Published: January 2021

Abstract
We study confining strings in $$ \mathcal{N} $$
N
= 1 supersymmetric SU(Nc) Yang-Mills theory in the semiclassical regime on ℝ1,2× 𝕊1. Static quarks are expected to be confined by double strings composed of two domain walls — which are lines in ℝ2 — rather than by a single flux tube. Each domain wall carries part of the quarks’ chromoelectric flux. We numerically study this mechanism and find that double-string confinement holds for strings of all N-alities, except for those between fundamental quarks. We show that, for Nc≥ 5, the two domain walls confining unit N-ality quarks attract and form non-BPS bound states, collapsing to a single flux line. We determine the N-ality dependence of the string tensions for 2 ≤ Nc≤ 10. Compared to known scaling laws, we find a weaker, almost flat N-ality dependence, which is qualitatively explained by the properties of BPS domain walls. We also quantitatively study the behavior of confining strings upon increasing the 𝕊1 size by including the effect of virtual “W-bosons” and show that the qualitative features of double-string confinement persist.
Coupled Boltzmann transport equations of heavy quarks and quarkonia in quark-gluon plasma
Authors: Yao Xiaojun , Ke Weiyao , Xu Yingru , Bass Steffen A. , Müller Berndt 
Published: January 2021

Abstract
We develop a framework of coupled transport equations for open heavy flavor and quarkonium states, in order to describe their transport inside the quark-gluon plasma. Our framework is capable of studying simultaneously both open and hidden heavy flavor observables in heavy-ion collision experiments and can account for both, uncorrelated and correlated recombination. Our recombination implementation depends on real-time open heavy quark and antiquark distributions. We carry out consistency tests to show how the interplay among open heavy flavor transport, quarkonium dissociation and recombination drives the system to equilibrium. We then apply our framework to study bottomonium production in heavy-ion collisions. We include ϒ(1S), ϒ(2S), ϒ(3S), χb(1P) and χb(2P) in the framework and take feed-down contributions during the hadronic gas stage into account. Cold nuclear matter effects are included by using nuclear parton distribution functions for the initial primordial heavy flavor production. A calibrated 2 + 1 dimensional viscous hydrodynamics is used to describe the bulk QCD medium. We calculate both the nuclear modification factor RAA of all bottomonia states and the azimuthal angular anisotropy coefficient v2 of the ϒ(1S) state and find that our results agree reasonably with experimental measurements. Our calculations indicate that correlated cross-talk recombination is an important production mechanism of bottomonium in current heavy-ion experiments. The importance of correlated recombination can be tested experimentally by measuring the ratio of RAA(χb(1P)) and RAA(ϒ(2S)).