bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Term Resource Conservation Technologies Sustained Yield, Microbial Activities and Soil Physico-chemical Properties in Rice-green Gram Cropping System
Authors: Dash Pradeep Kumar , Bhattacharyya Pratap , Shahid Mohammad , Kumar Upendra , Padhy Soumya Ranjan , Swain Chinmaya Kumar , Senapati Anshuman , Bihari Priyanka , Nayak Amaresh Kumar 
Published: November 2021

Abstract
PurposeMicrobial communities in rhizospheric soil play a significant role in sustaining the soil quality and also recognized as key ecological indicators to assess the soil health. MethodsWe studied the long-term effects of resource conservation technologies on functional microbial diversity and their interactions with soil biochemical properties and enzymatic activities in tropical rice-green gram cropping system. The experiment included conventional practice (CC), brown manuring (BM), green manuring (GM), wet direct drum sowing (WDS), zero tillage (ZT), green manuring-customized leaf colour chart based-N application (GM-CLCC N) and biochar (BC) treatments. ResultsThe result revealed that microbial biomass nitrogen (N), carbon (C) and phosphorus (P) in GM practice increased by 23.3, 37.7 and 35.1%, respectively over CC. The Shannon index and McIntosh index were higher by 86.9% and 29.2% in GM as compared to conventional practice and significantly correlated with microbial biomass (C & P) and soil microbial populations whereas, Shannon index was positively correlated with the microbial biomass (C, N & P) and soil enzyme activities. Principal component analysis showed a significant separate cluster among the treatments amended with and without biomass addition. ConclusionsMoreover, dominance of carbon utilizing microbes in biomass amended treatments indicated that these could supply good amount of labile carbon sources on real time basis for microbial activity. Which may protect the stable carbon fraction in soil, hence could support higher build-up of carbon in long run and could offer sustainable yield under rice-green gram soil.
Alpha-power in Electroencephalography as Good Outcome Predictor for Out-of-Hospital Cardiac Arrest Survivors
Authors: Kim Min-Jee , Kim Youn-Jung , Yum Mi-Sun , Kim Won Young 
Published: November 2021

Abstract
Background

This study aimed to identify the quantitative EEG biomarkers for predicting good neurologic outcomes in OHCA survivors treated with targeted temperature management (TTM) using power spectral density (PSD), event-related spectral perturbation (ERSP), and spectral entropy (SE).
Methods

This observational registry-based study was conducted at a tertiary care hospital in Korea using data of adult nontraumatic comatose OHCA survivors who underwent standard EEG and treated with TTM between 2010 and 2018. Good neurological outcome at 1 month (Cerebral Performance Category scores 1 and 2) was the primary outcome. The linear mixed model analysis was performed for PSD, ESRP, and SE values of all and each frequency band.
Results

Thirteen of the 54 comatose OHCA survivors with TTM and EEG, 13 were excluded due to poor EEG quality or periodic/rhythmic pattern, leaving 41 patients for analysis. The median time to EEG was 21 h, and the rate of the good neurologic outcome at 1 month was 52.5%. The good neurologic outcome group was significantly younger and showed higher PSD and ERSP and lower SE features for each frequency than the poor outcome group. After age adjustment, only the alpha-PSD was significantly higher in the good neurologic outcome group (1.13 ± 1.11 vs. 0.09 ± 0.09, p = 0.031) and had best performance with 0.903 of the area under the curve for predicting good neurologic outcome.
Conclusions

Alpha-PSD best predicts good neurologic outcome in OHCA survivors and is an early biomarker for prognostication. Larger studies are needed to conclusively confirm these findings.
Synthesis, Antibacterial Evaluation and in Silico Study of DOTA-fluoroquinolone Derivativessynthesis, Antibacterial Evaluation and in Silico Study of DOTA-fluoroquinolone Derivatives
Authors: Li Weitian , Hong Ge , Mao Lina , Xu Zengping , Wang Jiawen , Wang wenzhi , Liu Tianjun 
Published: November 2021

Abstract
A series of water-soluble fluoroquinolones based upon DOTA modification were synthesized and characterized by NMR and HRMS spectra. All the newly prepared quinolones compounds exhibited potent antimicrobial activities against MRSA, P. aeruginosa and E. coli. Molecular docking study indicated they could form stable complex with DNA gyrase and topoisomerase IV-DNA respectively, ADMET prediction showed they were low toxicity to the mice as whole. Among them, water-soluble quinolone 4c exhibited promising antibacterial potency, its MIC, MBC value for MRSA and P. aeruginosa was (1.56, 6.25) µg/mL, (3.1, 12.5) µg/mL respectively. Atomic Force Microscope (AFM) imaging revealed 4c could effectively destroy MRSA bacterial membrane and wall, causing its contents to leak out. Cytotoxicity assay showed 4c had low toxicity to L-02, A549 and MCF-7, over 80% cell viability even at 100 µmol/L. These results showed that water-soluble compound 4c was a promising antibacterial candidate.
Heat treatment-induced autophagy promotes invasion and metastasis via TGF-β2 mediated epithelial-mesenchymal transition in breast cancer cells
Authors: Li Zhen-Nan , Lu Cheng , Wang Feng-Liang , Guo Hao-Wei , Wang Zhi-Peng , Zhou Ping , Yin Hong , Li Jian 
Published: November 2021

Abstract
Background

Insufficient thermal ablation can cause accelerated malignant behaviors and increased metastasis in hepatocellular carcinoma (HCC), and epithelial-mesenchymal transition (EMT) and autophagy are implicated in tumor metastasis. However, whether interactions between autophagy and TGF-β2 induce EMT in breast cancer (BC) after insufficient microwave ablation (MWA) remains unclear.
Methods

In this study, we treated BC cells with sublethal heat treatment for simulating insufficient MWA, and then the effect of heat treatment on the BC cell phenotypes were explored. CCK-8, colony formation, flow cytometry, transwell and wound healing assays were performed to evaluate the influence of sublethal heat treatment on the proliferation, apoptosis, invasion and migration of BC cells treated with/without autophagy inhibitors. Western blotting, real-time quantitative PCR, immunofluorescence and transmission electron microscopy were carried out to determine the changes of markers associated with autophagy and EMT after sublethal heat treatment. Xenograft models in mice were established by using sublethal heat treated BC cells to investigate the effect of autophagy inhibitor on BC tumor growth in vivo.
Results

Results showed that heat treatment promoted the proliferation of survived BC cells, which was accompanied by autophagy induction. Heat treatment-induced autophagy up-regulated TGF-β2/Smad2 signaling and promoted phenotype of EMT, thereby enhancing abilities of migration and invasion in BC cells. Increase or decrease of TGF-β2 expression resulted in potentiation and suppression of autophagy as well as enhancement and abatement of EMT. Autophagy inhibitor facilitated apoptosis and repressed proliferation of BC cells in vitro, and thwarted BC cell tumor growth and pulmonary metastasis in vivo.
Conclusions

This study indicate that heat treatment-induced autophagy promotes invasion and metastasis via TGF-β2/Smad2-mediated EMT. Suppressing autophagy might be a new strategy for overcoming sufficient MWA caused progression and metastasis of residual BC cells.
Comparison Between Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients with Unstable Angina with Preserved Left Ventricular Systolic Function
Authors: Xiao Jiong , Liu Lin-Ze , Lin Wen-Hua 
Published: November 2021

Abstract
Background

We investigated the clinical results of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) treatment in patients with unstable angina (UA) with preserved left ventricular systolic function who underwent percutaneous coronary intervention (PCI) due to uncertainty regarding the long-term prognosis using ACEIs or ARBs.
Methods

A total of 1627 UA patients with preserved left ventricular systolic function who successfully underwent PCI were enrolled. We classified those patients into two groups: the ACEI group (n=918) and the ARB group (n=709) based on discharge medications. The primary endpoint was the incidence of major adverse cardiovascular and cerebrovascular events (MACCEs), including all-cause death, nonfatal myocardial infarction (MI), stroke and target vessel revascularization (TVR), with a follow-up period of 13 months. The secondary endpoint was the occurrence of separate components of MACCEs. We applied the Kaplan–Meier method to depict survival curves, while intergroup differences were performed using the log-rank test. Multivariable Cox regression analysis was applied to assess the prognostic influence of various factors. To balance potential confounding biases derived from differences in baseline levels, propensity score matching (PSM) was used to adjust for confounders between the ACEI and ARB groups.
Results

After PSM, 660 pairs in each group were created. There were no differences in MACCEs (HR=0.860, 95%CI: 0.465-1.590, P=0.630), all-cause death (HR=0.334, 95%CI: 0.090-1.238, P=0.101), non-fatal MI (HR=4.929, 95%CI: 0.576-42.195, P=0.145), stroke (HR=1.049, 95%CI: 0.208-5.290, P=0.954) and TVR (HR=1.276, 95% CI: 0.537-3.031, P=0.581) between the ACEI and ARB groups.
Conclusions

Prognoses were comparable between ACEI or ARB treatment in UA patients who had preserved left ventricular systolic function after PCI.
What Are The Determinants of Parametrial Invasion In Patients With Early Stage Cervical Cancer: A Cross Sectional Study
Authors: Hoorshad Niloufar , Zamani Narges , Hasani Shahrzad Sheikh , Poopak Amirhossein , Sharifi Amirsina 
Published: November 2021

Abstract
Background: There was an increase in number of patients presented with early-stage cervical cancer (CC). Tumors with favorable pathological features might be candidates for less radical surgery.Methods: We retrospectively reviewed 700 patients with histologically confirmed CC between January 2011 and March 2020. Chi-square, Fisher's exact tests and multivariate logistic regression analysis were used to assess relations between parametrial involvement (PI) and clinic-pathological variables.Results: Total number of 132 patients with stage IA to IIA were eligible to participate. Squamous cell carcinoma was reported in 100 (75.8%) patients, adenocarcinoma and other tumor pathologies were found in 24(18.2%) and 8(6.1%), respectively. Considering the FIGO stage, 11 (8.4%) patients had IA, 111 (83%%) IB and 10 (7.6%) IIA. Nine patients (6.8%) had PI on permanent pathologic report. Univariate analysis demonstrated that following variables were statistically different between patients with and without PI: age ≥ 50, tumor size ≥ 3cm, lower segment involvement, poorly differentiated pathology, deep stromal invasion, pelvic lymph node, lympho-vascular involvement and positive surgical margin (all p values < 0.05). Among these variables only tumor size ≥ 3 cm (OR: 2.1, 95% CI: 1.11-4.16, p value: 0.02), deep stromal invasion (OR: 2.2, 95% CI: 1.9-7.43, p value: 0.02) and positive surgical margin (OR: 5.1, 95% CI: 3.97-11.15, p value: 0.008) were independent risk factor of PI in multivariate analysis.Conclusions: Early stage CC can be surgically approached in a more conservative manner if patients have tumor size < 3 cm and do not have deep stromal invasion in conization.
Study on Reduction of 4-nitrophenol by Magnetic Maize Straw Supported with Copper Nanoparticles
Authors: Yu Yang , Guo Hong , Wang Pengyuan , Zhai Shangru , Han Jiazhi , Li Wenchao , Wang Yuanhao , Wang Yi 
Published: November 2021

Abstract
In this work, magnetic maize straw was prepared by the amidation process using renewable maize straw as starting material. After magnetic succinylated maize straw (Mag-S-MS) was mixed with cupric ions aqueous solution, Cu (II) could be captured by the amino and carboxylate groups. Then, the bonded Cu (II) was converted to valuable Cu nanoparticles (Cu NPS). It was characterized by SEM-EDS, XRD, XPS, and TGA, which indicated Cu NPS were formed successfully on Mag-S-MS without self-aggregation and oxidation. The above nanocomposites could be employed as a catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). The effect of the dosage of Cu NPS loaded-Mag-S-MS, the initial concentrations of NaBH4 and 4-NP were investigated, and a possible mechanism was discussed. The catalyst maintained relatively high catalytic activity after five cycle tests. Due to its superparamagnetic nature, it could be quickly collected from the aqueous solution under a magnetic field. These results could provide a method for using agricultural waste in nano catalytic reaction.
Influence of humic substances on the landfill leachate biodegradability with a focus on temporal seasonality
Authors: Moravia Wagner Guadagnin , Moreira Victor Rezende , Lebron Yuri Abner Rocha , Lange Liséte Celina , Santos Amaral Míriam Cristina 
Published: November 2021

Abstract
The high resilience to biological treatments from the landfill leachate is generally associated with the presence of humic substances (HS). The brown color characteristic of this effluent is also related to these substances. Landfill leachate with low biodegradability can make biological treatments unfeasible, which can drive up the cost for the treatment of large leachate volumes. In this context, this research aimed to characterize the leachate in different seasonal periods, and verify the influence of HS species on the biodegradability of the effluent to assist in the selection of adequate treatment techniques. The HS quantification was performed using the modified Lowry method and speciation through fractionation according to the molar masses of the HS species. The tropical regions can be the precursor for the rapid stabilization of biodegradable organic matter. The warmer climate contributed to a reduced BOD/COD ratio (0.03) and the predominance of compounds of lower mass (e.g.: fulvic acids). The tests showed an HS concentration of 26.9% of the total COD in the raw leachate in the rainy season, which increased to 37.3% in the dry season. Approximately 70% of HS species refer to fulvic acids, a fraction identified as having the highest biologic treatment resilience.
Optimization of the Sunset Yellow dye removal by electrocoagulation using a response surface method
Authors: Afshar Moghaddam Mitra , Seyyedi Kambiz 
Published: November 2021

Abstract
In recent years, among the various treatment methods, the electrocoagulation process has been used for the treatment of effluents containing various dye pollutants. Sunset Yellow (S.Y.) azo dye is one of the common food colors widely used in various food industries. This study investigated the removal of the dye S.Y. from aqueous media by the electrocoagulation method in an electrochemical reactor using concentric iron electrodes. The experiments were designed using the response surface method (RSM) with the help of Minitab software in such a way that the effect of various process-influencing parameters, such as current density, electrolysis time, electrolyte concentration, pH of the solution, and the effluent flow rate, on the desired pollutant removal efficiency was investigated. According to the results of the process optimization by RSM, the optimal conditions for the process were obtained as follows: pH of 10, current density of 2.65 mA/cm2, electrolysis time of 42.32 min, initial dye concentration of 20 mg/L, and effluent flow rate of 2.5 L/min. Under the above optimal conditions, the efficiency of dye removal was more than 99%.
LEVANTAMENTO DA MESOFAUNA EDÁFICA EM ÁREAS DE PROTEÇÃO DO MARANHÃO.
Authors: Chaves Rodrigues Judson , De Sousa Martins Alana Ellen , Oliveira Lima Francilene , Alves Souza Maria Tereza , De Alencar Costa Silva Maira  Rebeca , Pereira Gonçalves Márcia  Verônica , Lima Soares Francisco Ideilson , Araújo da Silva Formiga Luiza  Daiana 
Published: November 2021

O conhecimento da composição da comunidade da mesofauna edáfica é uma ferramenta importante para compreender o efeito sobre os processos edáficos e também para elucidar como a fauna do solo é afetada pela antropização, provocando mudanças no solo. Neste sentido, a pesquisa visa contribuir com o levantamento das ordens da mesofauna edáfica e sua dinâmica na Área de Proteção Ambiental Municipal do Buriti do Meio (Área I) e a Área de Proteção Ambiental do Inhamum (Área II). As coletas foram realizadas duas vezes durante o período seco, e duas vezes no período chuvoso, totalizando 4 coletas. Para a amostragem da mesofauna, foi utilizado armadilhas do tipo Provid e bateria de extratores Berlese-Tullgre. No laboratório foram feitas a triagem e quantificados os indivíduos e os dados foram analisados em diferentes programas. Foram contabilizados 12.486 indivíduos da mesofauna. Os indivíduos da ordem Collembola foram predominantes nas duas áreas. Ao comparar a abundância de indivíduos coletados nas duas armadilhas. Notou-se que a armadilha Provid se mostrou mais eficiente em relação a armadilha de Berllese Tüllgren. Foi analisada a diversidade das ordens entre os dois ambientes estudados (Shannon-Wiener), a Área II obteve o maior índice de diversidade, sendo confirmado pelo Índice de Pielou (J).

Palavras-chave: Berlese-Tullgren, Diversidade, Provid.
AGRICULTURA DE SUBSISTÊNCIA E MUDANÇAS CLIMÁTICAS: CASOS DOS DISTRITOS DE MAGUDE E MOAMBA (SUL DE MOÇAMBIQUE)
Authors: Jalane Orlando Inacio , Silva Edson Vicente da , Sopchaki Carlos Henrique 
Published: November 2021

O presente ensaio aborda os efeitos das mudanças do clima na agricultura de subsistência (familiar) moçambicana, em terras com tendências climáticas semiáridas, como são os distritos a sul de país, casos de Magude e Moamba, na província de Maputo. A pesquisa foi desenvolvida a partir de levantamentos bibliográficos e observação direta dos autores, que vivenciaram a realidade local. Existe uma tendência cíclica de anos de seca extrema, precididos por outros de excessos de precipitação e ligeira concentração em períodos cada vez mais curtos, o que dificulta a capacidade dos solos de absorverem os impactos das águas. No presente trabalho busca-se evidenciar a grande exposição da agricultura de subsistência em regiões semiáridas, face aos cenários climáticos adversos e como isso pode impactar na vida dos agricultores e suas famílias, bem como na dieta alimentar do país.
Palavras-chave: agricultura de subsistência; Semiárido; Mudanças climáticas.
INFLUÊNCIA DOS PROCESSOS DIAGENÉTICOS NA POROSIDADE DOS ARENITOS DA FORMAÇÃO IBOREPI, BACIA DE LAVRAS DA MANGABEIRA, ESTADO DO CEARÁ
Authors: Vieira Batista Zenilda , Ferreira de Lima Filho Mário , Rodrigues de Andrade Freitas Wilson , Marques Vieira Marcela , Oliveira Agostinho da Silva Sonia Maria , Silva Valdielly Larisse 
Published: November 2021

Análises de processos diagenéticos que atuaram sobre os arenitos da Formação Iborepi foram realizadas em amostras de rochas da Bacia Lavras da Mangabeira. A petrologia e a diagênese desses arenitos é pouco conhecida, principalmente quanto aos processos diagenéticos que atuaram sobre a porosidade original dessas rochas, que podem ser estudadas como análogos de reservatórios de bacias petrolíferas. Estudos petrológico e petrográfico foram realizados em nove lâminas, a fim de avaliar os processos diagenéticos que impactaram a porosidade original dos arenitos Iborepi. Os processos encontrados foram: argila infiltrada como cutículas envolvendo grãos e agregados microcristalinos intersticiais; compactação mecânica e química gerando fraturas em grãos, pseudomatriz em litoclastos dúcteis, micas dobradas e dissolução de grãos originando contatos côncavo-convexos e suturados; precipitação de crescimentos secundários (overgrowths) e projeções de quartzo (outgrowths), caulinita, esmectita e clorita; alteração e substituição de feldspato potássico, muscovita e biótica por caulinita, ilita e clorita. A porosidade dessas rochas é predominantemente primária intergranular, com média de 14%, porém, ocorre porosidade secundária por fratura e dissolução de grãos primários e encolhimento de argila. De modo geral, a porosidade primária dos arenitos Iborepi foi reduzida principalmente por compactação mecânica e química, ciemntação e infiltração de argila, impactando sua qualidade como reservatório de hidrocarbonetos.
Palavras-chave: Arenitos, porosidade, reservatório.
Relacje Konferencji Episkopatu Polski z władzami Polskiej Rzeczypospolitej Ludowej w latach 1980-1981
Authors: Stępień Marek 
Published: November 2021

After the Second World War communists took over the power in Poland. The main purpose of the ruling party was introducing the principles of Marxist philosophy. In the center of ideological fight was the Roman Catholic Church perceived as serious obstacle or even threat in achieving their goals.
In the years 1980-1981, the Polish authorities again declared their will to normalize relations and to reactivate the Joint Commission of the Government and the Episcopate. The communists as the rulers counted on the help of the Church in calming social moods and normalizing the situation after the unrest and strikes that took place at that time. The talks however did not bring any significant effects. Only a few small matters were settled.
Porphyromonas gingivalis Lipopolysaccharide-Induced B Cell Differentiation
by Toll-like Receptors 2 and 4
Authors: Liu Sumei , Liu Guojing , Luan Qingxian , Ma Yongping , Yu Xiaoqian 
Published: November 2021

Background:
Porphyromonas gingivalis (P. gingivalis) is a pathogenic bacterium widely
present in subgingival plaques of patients with periodontitis. It induces periodontitis with bone
loss as its main feature by changing the number and composition of symbiotic microorganisms, as
well as inducing the natural immune response of the host. However, the mechanism of the latter remains
unclear.

Objective:
This study aims to investigate the effect of P. gingivalis lipopolysaccharide (LPS) on
regulatory B cells (Breg) in the occurrence and development of periodontitis.

Method:
We detected the mRNA levels of IL-10 in B cells under the stimulation of P. gingivalis
LPS and/or E. coli LPS, distinguished IL-10-producing cells from different B cell subgroups using
flow cytometry. Through toll-like receptor (TLR) knockout mice, the role of TLR2 and TLR4 in
this process was also evaluated.

Results:
Results showed that P. gingivalis stimulated B cells to produce IL-10 via TLR2/4.
CD5+B1 subset is the main source of IL-10+Breg cell. Under P. gingivalis LPS stimulation,
CD5+IgM+CD93-IL-10+B cell subset increased significantly, which was regulated through TLR2/
4.

Conclusion:
The results of this study provides new insights into the immunopathogenic mechanism
of P. gingivalis, preliminarily discussed the effect of P. gingivalis on the production of Breg,
and present a theoretical foundation for subsequent investigations on the occurrence and development
of periodontitis.