bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts on and Care of Psychiatric Patients during the Outbreak of COVID-19
Authors: Puangsri Pavarud , Jinanarong Vinn , Wattanapisit Apichai 
Published: July 2021

The outbreak of coronavirus disease (COVID-19) in December 2019 has led to massive lifestyle, economic, and health changes. The COVID-19 pandemic has had broad impacts on psychiatric patients, exacerbating symptoms such as psychosis, depression, and suicidal ideation. Therefore, we aimed to review the psychological impacts of COVID-19 on psychiatric patients and mental healthcare staff and provide practical guidance for medical staff and authorities.The main findings of this review included the impacts of COVID-19 on psychiatric patients and mental health professionals as well as the transformation of mental health care. Greater consideration should be given to the care of patients with psychosis and depression because of their lack of self-care ability, neurocognitive impairment, and impaired immune function. Depressive symptoms can be exacerbated due to several factors, such as economic crises, social isolation, and limited physical activity. Unemployment and financial problems can lead to an increased suicide rate. Consequently, mental healthcare workers’ workload can increase, which could lead to burnout and psychological symptoms such as insomnia, depression, and anxiety.A transformation of psychiatric care is needed during the time of the pandemic. While emergency care should be maintained, outpatient care should be limited to decrease viral spread. Shifting care to telemedicine and community-based psychiatry can be helpful. Inpatient services should be adapted by tightening admission criteria, shortening the length of hospital stays, suspending some group activities, limiting visitors, and preparing for quarantine if necessary. Mental healthcare workers can be supported with telecommunication, appropriate work shifts, alternative accommodations, and good communication between the team leader and staff.
Recent Patents on a Discharge State Detection of EDM
Authors: Xie Baocheng , Liu Le , Ji Xuhui , Wang Yi , Zeng Zhaoqi , Gou Haoliang , Zhang Bing 
Published: July 2021

Background:
Electrical Discharge Machining (EDM) has been widely applied in manufacturing
high strength and high hardness of mental material due to no mechanical forces in the EDM
process. The discharge state, an important process parameter of EDM, directly affects the machining
quality and machining efficiency. So, it is necessary to detect the real-time discharge state of EDM.
Therefore, discharge state detection of EDM at present has been paid more and more attention.

Objective:
To meet the increasing requirement of machining quality and machining efficiency in the
EDM process, the methods for discharge state detection of EDM are being improved continuously.

Methods:
This paper reviews various representative patents related to the methods for discharge
state detection of EDM.

Results:
By summarizing numerous patents about the methods for discharge state detection of
EDM, the main problems such as low detection accuracy and long delay time of discharge state detection
of EDM are summarized and analyzed. In addition, the further development of discharge
state detection method of EDM is discussed.

Conclusion:
The optimization of methods for discharge state detection is conducive to improving
machining quality and machining efficiency in the EDM process. Moreover, more relevant patents
will be invented in the future.
Effect of Low-Dose Corticosteroid Use on HBV Reactivation in HBsAg-positive Rheumatoid Arthritis Patients
Authors: Jeong Wooseong , Choe Jung-Yoon , Song Byung-Cheol , Lee Chang-Keun , Cha Hoon-Suk , Ghang Byeongzu , Kim Jinseok 
Published: July 2021

Background:
It is well known that the use of corticosteroids (CS) results in increased viral replication and elevated alanine aminotransferase in hepatitis B virus (HBV) patients. However, only a few studies have investigated the effect of low-dose CS on HBV reactivation. In addition, there are few studies on the effects of synthetic disease-modifying anti-rheumatic drugs on HBV reactivation.

Objective:
We investigated the reactivation of HBV in rheumatoid arthritis (RA) patients treated with long-term low-dose corticosteroids. In addition, we analyzed factors affecting HBV reactivation, including disease-modifying anti-rheumatic drugs.

Methods:
We retrospectively reviewed medical records and analyzed the incidence of HBV reactivation in RA patients who were hepatitis B surface antigen (HBsAg) positive and who were receiving ≤10 mg of prednisolone over 4 weeks. Logistic regression analysis was performed to investigate the factors that increase the risk of HBV reactivation.

Results:
A total of 141 patients were included in the study, out of which 24 (17.0%) patients had HBV reactivation. The administration of low-dose corticosteroids did not affect HBV reactivation in HBsAg-positive RA patients (odds ratio: 0.807, 95% confidence interval: 0.143–4.546, p = 0.808), nor did the duration of corticosteroid administration, average daily corticosteroid dose, and cumulative corticosteroid dose. Administration of leflunomide was found to significantly increase the risk of HBV reactivation (odds ratio: 3.851, 95% confidence interval: 1.026–14.459, p = 0.046).

Conclusion:
The administration of low-dose corticosteroids did not affect the rate of HBV reactivation, suggesting that it can be used safely. Leflunomide may increase the risk of HBV reactivation; therefore, HBV patients should be carefully monitored when receiving this drug.
Aqueous-based Nanoemulsion Containing (-)-α-bisabolol for Topical
Treatment of Skin Burns
Authors: Gelfuso Guilherme M. , Almeida Edson A.T. , Ferreira-Nunes Ricardo , Aguiar Beatriz R.L. , dos Reis Paula E.D. , Gratieri Tais , Cunha-Filho Marcilio 
Published: July 2021

Background:
α-Bisabolol (BIS) is a sesquiterpene extracted from the chamomile flowers, whose use to topically treat burn skin has been reported. High lipophilicity of BIS, however, is a problem for both skin application and washing.

Objective:
The present study aimed to prepare and characterize a stable and safe aqueous-based nanoemulsion to incorporate BIS and favor skin penetration focusing on skin burns' topical treatment.

Method:
Oil-in-water nanoemulsions were obtained from a pseudo-ternary phase diagram. The selected nanoemulsion was characterized (droplet size, PDI, and zeta potential), and the stability was assessed for 60 days at 6ºC and room temperature. The irritability of the formulation was determined by HET-CAM. Skin permeation studies were carried out in vitro intact skin, hot wa-ter burn skin, and hot plate burn skin.

Results:
The nanoemulsion incorporated 1% (w/w) BIS, presented droplets' size of 14.0±0.8 nm (PDI= 0.13±0.02), the zeta potential of +7.5±1.9 mV, and was physically stable over 60 days. The HET-CAM did not show any irritability process provided by the nanoformulation. In the skin permeation experiments, when compared to an oily control solution of BIS, nanoemulsion increased 3.7-fold penetration of the drug in intact skin, likely because the nanoformulation act-ed as an absorption drug enhancer. On a hot water burn skin model, the increase in drug pene-tration was 1.7-fold, and in the hot plate burn skin, it was 2.3-fold.

Conclusion:
The nanoemulsion seems to be a promising alternative for skin burns' topical treatment using this natural active.
Fases de implementación de Blended Learning en las universidades españolas. Estudio basado en análisis de segmentación.
Authors: Martín García Antonio Víctor , Gutiérrez Pérez Bárbara Mariana , Martín Lucas Judith 
Published: July 2021

El objetivo principal de este estudio es conocer y describir las fases de adopción de lamodalidad formativa denominada blended learning (BL). Se aplicó una encuesta a 980profesores de universidades públicas de todo el estado español. El análisis de los datosse realizó mediante técnicas de clustering para la agrupación de los sujetos (análisis desegmentación mediante el algoritmo CHAID). Los resultados ofrecen claves paracomprender por qué los docentes universitarios adoptan o no esta modalidad deenseñanza, identificando perfiles o rasgos que caracterizan cada uno de los subgruposagrupados en cada una de las fases de adopción (tomadas como variables criterio), enfunción de una serie de características personales y profesionales (Sexo, Edad;Categoría profesional, Área de conocimiento, Experiencia docente, Actitud hacia BL,Nivel de Autoeficacia), y variables contextuales relacionadas con Formación recibidasobre BL en la universidad. Todas ellas variables predictoras. De manera indirecta, esteconocimiento sobre las fases de adopción puede aportar información sobre el estadio dedifusión institucional de la metodología B-Learning en el conjunto de la universidadespañola.
Anatomical premises for the variability of the results of transobturator mid-urethral sling
Authors: Kovalev G. V. , Shkarupa D. D. , Kubin N. D. , Nichiporuk G. I. , Gaivoronsky I. V. 
Published: July 2021

Introduction. The implantation of a synthetic sub-urethral sling is the main method of surgical correction of stress urinary incontinence (SUI). However, the investigation results of long-term effectiveness indicate the ambiguity of the surgery outcomes. In addition, the problem of pain in the perineum remains relevant for everyday practice. One of the important aspects in this matter may be a variant technique for installing a suburethral sling, including based on the anatomical variability of the small pelvis.Purpose of the study. To identify key anatomical factors that can negatively affect the effectiveness and safety of the environment of suburethral sling surgery for urinary incontinence in women.Materials and methods. The study consisted of 2 parts - anatomical and clinical. In the anatomical part of the study, a suburethral sling was implanted on 20 preparations of a female pelvis with a lower limb and preserved soft tissues. The clinical part of the study involved 50 patients with stress urinary incontinence. These patients underwent installation of a transobturator suburethral sling in two ways using the “inside-out” technique: using the standard “external landmarks” technique and using the proposed anatomical technique developed in the first part of the study. After visualization of the suburethral sling using the original method, the outcomes of the operations were assessed depending on the location of the sling in the patient's tissues.Results. In the anatomical part of the study, the most atraumatic method of suburethral sling implantation was determined by rotating the tool around the lower branch of the pubic bone. In the clinical part of the study, this method demonstrated a higher efficiency of the operation at a follow-up of 1 year, presumably due to the U-shaped angle of the «hammock» for the urethra, which is characteristic of the retropubic sling.Conclusion. Outcomes of operations for SUI depend, among other things, on the method of the suburethral sling implantation.
Benign masses of the female paraurethral region
Authors: Mansur A. , Shaplygin L. V. , Derevianko T. I. , Pospelova O. M. , Kabardokov T. A. 
Published: July 2021

Introduction. Benign female paraurethral masses (BFPM) are not often found during practice. This is due to the small size of the BMP and the low specificity and effectiveness of imaging techniques (urethrocystography, ultrasound, computed tomography).Purpose of the study. To determine the frequency and structure of female BMP.Materials and methods. We conducted a retrospective analysis of the female medical records (n = 5,112) who went to the urologist in 2018 with complaints of a frequent and painful urination. In this population, 92 (1.79%) patients were diagnosed with BFPM.Results. In the structure of BFPM, the most common is urethral diverticulum -57 (61.9%) and paraurethral cyst - 24 (26%). In other cases, we identified a urethral polyp and leiomyoma in 7 (7,6%) и 4 (4,5%) of cases, respectively. The average womens' age who were diagnosed with was 29.2 ± 7.3 years. BFPM were detected most often in women aged 26 to 35 years (48.9%). All patients complained of frequent urination. We have recorded the following complaints as well: feeling of a foreign body in the perineum - 77.1%, imperative urinary urgency - 64.1%, perineal pain - 28.2%, dyspareunia - 26%, difficulty urinating - 14.1%. The above-mentioned complaints were noted within 1 year by more than half of women (72.8%).Conclusions. BFPM were diagnosed in 1.79% of women. Of these, 2/3 of cases were urethral diverticula, and % of cases were paraurethral cyst. The diagnosis of BFPM should be comprehensive and combine examination, palpation and instrumental (ultrasound, urethrocystoscopy, MRI) diagnosis of the urethral region.
Cross-Canada Release of the Post-Secondary Student Stressors Index (PSSI): Protocol for a Cross-sectional, Repeated Measures Study
Authors: Linden Brooke 
Published: July 2021

Background
The prevalence of mental health–related problems, including stress, psychological distress, and symptoms of mental illnesses, continues to increase among Canadian postsecondary student populations. Excessive stress in this population has been linked to a number of negative academic and health outcomes. Despite attempts to improve mental health at postsecondary institutions, a persistent gap exists in the evaluation of the specific sources of stress for students within the postsecondary setting.

Objective
The purpose of this paper is to report the study protocol for a cross-Canada, multisite launch of the Post-Secondary Student Stressors Index (PSSI), which will engage postsecondary institutions across the country as partners and facilitate improved measurement of the sources of student stress, in addition to contributing toward improved tailoring of upstream mental health services and support.

Methods
Created in collaboration with students, the PSSI is a validated 46-item tool assessing stressors across five domains: academics, learning environment, campus culture, interpersonal, and personal stressors. The tool is designed to be applicable to students at all years, levels, and areas of study. Data will be collected longitudinally at multiple time points over the course of each academic year.

Results
We recruited 15 postsecondary institutions across Canada for the first year, inviting students to participate in an online survey including questions concerning sociodemographic characteristics, stress, mental health, and resiliency. Analyses, including appropriate data visualization, will be conducted to determine the impact of specific stressors on mental health, linking responses over time to allow for the observation of changes in trends.

Conclusions
The PSSI is an intuitive and evidence-informed tool that can aid postsecondary institutions in evaluating the sources of student stress on their campuses. This multisite project will make a substantial contribution to the current literature regarding postsecondary student stress and allow institutions across the country to improve the tailoring of upstream mental health services in order to directly support the unique needs of their student body. Opportunities for knowledge translation and exchange are discussed.

International Registered Report Identifier (IRRID)
DERR1-10.2196/27713
Prediction of Incident Atrial Fibrillation in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort Study
Authors: Zelnick Leila R. , Shlipak Michael G. , Soliman Elsayed Z. , Anderson Amanda , Christenson Robert , Lash James , Deo Rajat , Rao Panduranga , Afshinnia Farsad , Chen Jing , He Jiang , Seliger Stephen , Townsend Raymond , Cohen Debbie L. , Go Alan , Bansal Nisha 
Published: July 2021

Background and objectives
Atrial fibrillation (AF) is common in CKD and associated with poor kidney and cardiovascular outcomes. Prediction models developed using novel methods may be useful to identify patients with CKD at highest risk of incident AF. We compared a previously published prediction model with models developed using machine learning methods in a CKD population.

Design, setting, participants, & measurements
We studied 2766 participants in the Chronic Renal Insufficiency Cohort study without prior AF with complete cardiac biomarker (N-terminal pro–B-type natriuretic peptide and high-sensitivity troponin T) and clinical data. We evaluated the utility of machine learning methods as well as a previously validated clinical prediction model (Cohorts for Heart and Aging Research in Genomic Epidemiology [CHARGE]-AF, which included 11 predictors, using original and re-estimated coefficients) to predict incident AF. Discriminatory ability of each model was assessed using the ten-fold cross-validated C-index; calibration was evaluated graphically and with the Grønnesby and Borgan test.

Results
Mean (SD) age of participants was 57 (11) years, 55% were men, 38% were Black, and mean (SD) eGFR was 45 (15) ml/min per 1.73 m2; 259 incident AF events occurred during a median of 8 years of follow-up. The CHARGE-AF prediction equation using original and re-estimated coefficients had C-indices of 0.67 (95% confidence interval, 0.64 to 0.71) and 0.67 (95% confidence interval, 0.64 to 0.70), respectively. A likelihood-based boosting model using clinical variables only had a C-index of 0.67 (95% confidence interval, 0.64 to 0.70); adding N-terminal pro–B-type natriuretic peptide, high-sensitivity troponin T, or both biomarkers improved the C-index by 0.04, 0.01, and 0.04, respectively. In addition to N-terminal pro–B-type natriuretic peptide and high-sensitivity troponin T, the final model included age, non-Hispanic Black race/ethnicity, Hispanic race/ethnicity, cardiovascular disease, chronic obstructive pulmonary disease, myocardial infarction, peripheral vascular disease, use of angiotensin-converting enzyme inhibitor/angiotensin receptor blockers, calcium channel blockers, diuretics, height, and weight.

Conclusions
Using machine learning algorithms, a model that included 12 standard clinical variables and cardiac-specific biomarkers N-terminal pro–B-type natriuretic peptide and high-sensitivity troponin T had moderate discrimination for incident AF in a CKD population.
Hubungan Usia, Jenis Kelamin dan Hipertensi dengan Kejadian Diabetes Mellitus Tipe 2 di Puskesmas Tugu Kecamatan Cimanggis Kota Depok Tahun 2019
Authors: Gunawan Susilawati , Rahmawati Rista 
Published: July 2021

ABSTRAK
Diabetes mellitus adalah salah satu penyakit tidak menular yang hingga saat ini menunjukkan peningkatan.Faktor-faktor yang dapat menyebabkan terjadinya diabetes mellitus tipe 2 diantaranya adalah usia, jenis kelamin dan hipertensi. Penelitian ini bertujuan untuk mengidentifikasi hubungan usia, jenis kelamin dan hipertensi dengan kejadian diabetes mellitus tipe 2 di Puskesmas Tugu Kecamatan Cimanggis Kota Depok tahun 2019. Metode penelitian ini adalah survei analitik dengan rancangan case control. Sampel penelitian ini terdiri dari 132 sampel kelompok kasus dan 132 sampel kelompok kontrol. Pengumpulan data yang digunakan dalam penelitian ini yaitu data sekunder. Analisis untuk uji hipotesis menggunakan uji statistik chi-square dengan Î± = 0,05 dan CI = 95%. Hasil penelitian menunjukkan bahwa ada hubungan antara usia dengan kejadian diabetes mellitus tipe 2 dengan nilai p value = 0,000 < Î± (0,05) dan nilai OR = 18,143 (95% CI 6,959-47,302). Tidak ada hubungan antara jenis kelamin dengan kejadian diabetes mellitus tipe 2 dengan nilai p value = 0,519 > Î± (0,05) dan nilai OR = 1,222 (95% CI 0,736-2,029). Tidak ada hubungan antara hipertensi dengan kejadian diabetes mellitus tipe 2 dengan nilai p value = 0,879 > Î± (0,05) dan nilai OR = 1,098 (95% CI 0,603-1,997). Determinan yang berhubungan dengan kejadian diabetes mellitus tipe 2 adalah usia. Sedangkan determinan yang tidak berhubungan dengan kejadian diabetes mellitus tipe 2 adalah jenis kelamin dan hipertensi.
Kata Kunci: Usia, Jenis Kelamin, Hipertensi, Diabetes Mellitus tipe 2
Coronavirus Jakarta: Perbandingan Pemukiman Kumuh dan Pemukiman Mewah
Authors: Wahyudin Marwan 
Published: July 2021

ABSTRAK
Kasus Coronavirus Disease 2019 (COVID-19) sudah merebak ke lebih dari 200 negara, salahsatunya Indonesia. Episentrum penyebaran COVID-19 di Indonesia adalah DKI Jakarta. KepadatanDKI Jakarta sebagai ibu kota negara menimbulkan banyak permasalahan seperti buruknyapemukiman. Terjadinya pemisahan antara pemukiman kumuh dan mewah adalah hasil persaingantingkat dan ekonomi penduduk. Selama pandemik berlangsung belum diketahui apakah pemukimankumuh atau pemukiman mewah yang lebih terdampak. Penelitian ini bertujuan untuk mengetahuiperbedaan antara pemukiman kumuh dengan pemukiman mewah pada kasus COVID-19. Data yangdigunakan adalah data harian COVID-19 DKI Jakarta dari tanggal 25 Maret 2020 sampai dengan18 Oktober 2020 dengan menggabungkan data Badan Pusat Statistik berupa muatan dominan, yaitupemukiman kumuh dan mewah. Berdasarkan hasil penelitian, secara rata-rata harian keseluruhanjumlah kasus positif di pemukiman kumuh mencapai 65,58 kasus sedangkan pada pemukimanmewah mencapai 56,57 kasus. Pemukiman kumuh cenderung lebih beresiko terkena COVID-19dikarenakan ekonomi dan sulitnya akses kesehatan. Ditemukan perbedaan nyata antara pemukimankumuh dan mewah terhadap variabel kasus positif, pasien sembuh, pasien dirawat, pasienmeninggal, dan pasien yang melakukan isolasi mandiri. Perlunya penangan lebih tepat padapemukiman kumuh agar bisa mengurangi dampak yang terjadi.
Kata Kunci: Pemukiman, Kumuh, Mewah, Jakarta, COVID-19
Hubungan Sanitasi Lingkungan Dan Riwayat Penyakit Infeksi Dengan Kejadian Stunting Di Kota Parepare
Authors: Abidin Sri Wahyuni , Haniarti  , Sari Rasidah Wahyuni 
Published: July 2021

ABSTRAK
Stunting adalah kondisi dimana balita memiliki panjang atau tinggi badan yang kurang jika dibandingkan dengan umur. Hasil Riskesdas Tahun 2018 diketahui bahwa jumlah balita sangat pendek dan pendek usia 0-59 bulan di Indonesia adalah 11,5% dan 19,3%. Stunting dapat disebabkan oleh beberapa faktor, diantaranya ialah sanitasi lingkungan dan riwayat penyakit infeksi. Penelitian ini bertujuan untuk mengetahui hubungan antara ketersediaan sumber air bersih, kepemilikan jamban keluarga, riwayat penyakit diare dan riwayat penyakit ISPA dengan kejadian stunting. Metode yang digunakan adalah metode survei analitik dengan pendekatan Cross Sectional Study dan jumlah sampel 275 balita yang berusia 24-59 bulan. Teknik pengambilan sampel dalam penelitian ini adalah Accidental Sampling menggunakan analisis univariat dan analisis bivariat dengan uji Chi-Square, dan waktu penelitian dilakukan pada bulan Juni sampai Agustus Tahun 2020. Hasil analisis uji statistik menunjukkan bahwa tidak terdapat hubungan yang signifikan antara ketersediaan sumber air bersih (p = 0,319), kepemilikan jamban keluarga (p = 0,588), riwayat penyakit diare (p = 0,245), dan riwayat penyakit ISPA (p = 0,988) dengan kejadian stunting. Disarankan kepada peneliti selanjutnya agar melakukan penelitian dengan mengambil variabel lain seperti tinggi orang tua, asupan gizi, riwayat menyusui, dan aktivitas fisik.
Kata kunci: Stunting, Air, Jamban, Diare, ISPA