bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climatology and physical mechanisms of the tropospheric warm cores over the Tibetan Plateau and its vicinity
Authors: Shang Ke , Liu Xiaodong , Dong Buwen 
Published: April 2021

AbstractThe frequently observed tropospheric warm cores over the Tibetan Plateau (TP) are unique climate phenomena and are crucial to the Asian summer monsoon development. However, their climatological structure and formation mechanisms remain elusive and inconsistent among previous studies. In this work, two vertically separated warm cores, the upper-level warm cores (ULWCs) and lower-level warm cores (LLWCs), are identified based on the zonal temperature deviation. The LLWCs are basically confined below 450 hPa, and the ULWCs are mostly observed at 200–400 hPa. The active region of the LLWCs is generally within the TP domain and characterized by regional patches with high frequency occurrences. In contrast, the active region of the ULWCs is featured by a zonally elongated band along the southern TP. The physical mechanisms for the formations of these two distinct types of warm cores are revealed: the LLWCs are mainly generated and maintained by the surface diabatic heating, while the ULWCs are dominated by the large-scale circulation associated with the convection over the Indo-Pacific warm pool. During March–June, the ULWCs within the TP domain occur most frequently and the intensities attain their maxima. In March–April, the ULWCs are mainly determined by the TP adiabatic subsidence induced by the convection over the Indo-Pacific warm pool. In May–June, the warm advection induced by westerlies generates the downstream ULWCs and enhances the ULWCs formed in previous months. Hence it might be inappropriate in traditional view to attribute the tropospheric warm cores around the TP solely to the direct thermal effect of the elevated topography.
Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes
Authors: Lieder Helmut Raphael , Braczko Felix , Gedik Nilgün , Stroetges Merlin , Heusch Gerd , Kleinbongard Petra 
Published: April 2021

AbstractIschemic post-conditioning (iPoCo) by coronary re-occlusion/reperfusion during immediate reperfusion after prolonged myocardial ischemia reduces infarct size. Mechanical manipulation of culprit lesions, however, carries the risk of coronary microembolization which may obscure iPoCo’s cardioprotection. Pharmacological post-conditioning with exogenous triiodothyronine (T3) could serve as an alternative conditioning strategy. Similar to iPoCo, T3 may activate cardioprotective prosurvival pathways. We aimed to study T3’s impact on infarct size and its underlying signal transduction. Hearts were isolated from male Lewis rats (200–380 g), buffer-perfused and subjected to 30 min/120 min global zero-flow ischemia/reperfusion (I/R). In additional hearts, either iPoCo (2 × 30 s/30 s I/R) was performed or T3 (100–500 µg/L) infused at reperfusion. Infarct size was demarcated with triphenyl tetrazolium chloride staining and calculated as percent of ventricular mass. Infarct size was reduced with iPoCo to 16 ± 7% vs. 36 ± 4% with I/R only. The maximum infarct size reduction was observed with 300 µg/L T3 (14 ± 2%). T3 increased the phosphorylation of protein kinase B and mitogen extracellular-regulated-kinase 1/2, both key enzymes of the reperfusion injury salvage kinase (RISK) pathway. Pharmacological RISK blockade (RISK-BL) during reperfusion abrogated T3’s cardioprotection (35 ± 10%). Adult ventricular cardiomyocytes were isolated from buffer-perfused rat hearts and exposed to 30 min/5 min hypoxia/reoxygenation (H/R); reoxygenation was initiated without or with T3, respectively, and without or with RISK-BL, respectively. Maximal preservation of viability was observed with 500 µg/L T3 after H/R (27 ± 4% of all cells vs. 5 ± 3% in time-matched controls). Again, RISK-BL abrogated protection (11 ± 3%). Mitochondria were isolated at early reperfusion from buffer-perfused rat hearts without or with iPoCo or 300 µg/L T3, respectively, at reperfusion. T3 improved mitochondrial function (i.e.: increased respiration, adenosine triphosphate production, calcium retention capacity, and decreased reactive oxygen species formation) to a similar extent as iPoCo. T3 at reperfusion reduces infarct size by activation of the RISK pathway. T3’s protection is a cardiomyocyte phenomenon and targets mitochondria.
Etiologies and clinical characteristics of young patients with angle-closure glaucoma: a 15-year single-center retrospective study
Authors: Gao Feng , Wang Jiajian , Chen Junyi , Wang Xiaolei , Chen Yuhong , Sun Xinghuai 
Published: April 2021

Abstract
Purpose
To investigate the etiologies and the clinical characteristics of angle-closure glaucoma (ACG) patients younger than 40 years old in Chinese.

Methods
Inpatients with diagnosis of ACG and diagnosed age younger than or equal to 40 years old, who were admitted in Eye, Ear, Nose, and Throat Hospital Fudan University from 2002 to 2017, were included in this retrospective non-comparative case series. The underlying causes and clinical features for all the patients were analyzed by comprehensive review of medical charts.

Results
A total of 298 patients (463 eyes) met the criteria, including 153 females (51.3%) and 145 males (48.7%); the mean age was 25.6 ± 13.0 years. Primary angle-closure glaucoma (PACG), uveitis, and anterior segment dysgenesis (ASD) were the top three etiologies in our patients, which accounted for 32.6%, 20.3%, and 15.1% of the total patients respectively. PACG mainly occurs after 30 years of age and ASD is the top reason of ACG in patients younger than 20 years old. Other known etiologies include iridocorneal endothelial syndrome, neovascular glaucoma, nanophthalmos, retinitis pigmentosa, spherophakia, bestrophinopathy, persistent fetal vasculature, iridociliary cysts, congenital retinoschisis, Marfan’s syndrome, retinopathy of prematurity, familial exudative vitreoretinopathy, congenital retinal folds, Coat’s disease, and neurofibromatosis.

Conclusions
We described the uncommon presentation of ACG in Chinese young patients. Although unusual, most of the etiologies could be identified. Therefore, more careful and comprehensive examinations are needed for early detection and timely treatment for young ACG patients.
The impact of nurse staffing levels on nursing-sensitive patient outcomes: a multilevel regression approach
Authors: Dietermann Karina , Winter Vera , Schneider Udo , Schreyögg Jonas 
Published: April 2021

AbstractThe goal of this study is to provide empirical evidence of the impact of nurse staffing levels on seven nursing-sensitive patient outcomes (NSPOs) at the hospital unit level. Combining a very large set of claims data from a German health insurer with mandatory quality reports published by every hospital in Germany, our data set comprises approximately 3.2 million hospital stays in more than 900 hospitals over a period of 5 years. Accounting for the grouping structure of our data (i.e., patients grouped in unit types), we estimate cross-sectional, two-level generalized linear mixed models (GLMMs) with inpatient cases at level 1 and units types (e.g., internal medicine, geriatrics) at level 2. Our regressions yield 32 significant results in the expected direction. We find that differentiating between unit types using a multilevel regression approach and including postdischarge NSPOs adds important insights to our understanding of the relationship between nurse staffing levels and NSPOs. Extending our main model by categorizing inpatient cases according to their clinical complexity, we are able to rule out hidden effects beyond the level of unit types.
Bootstrapping MDE development from ROS manual code: Part 2—Model generation and leveraging models at runtime
Authors: Hammoudeh García Nadia , Deshpande Harshavardhan , Santos André , Kahl Björn , Bordignon Mirko 
Published: April 2021

AbstractModel-driven engineering (MDE) addresses central aspects of robotics software development. MDE could enable domain experts to leverage the expressiveness of models, while implementation details on different hardware platforms would be handled by automatic code generation. Today, despite strong MDE efforts in the robotics research community, most evidence points to manual code development being the norm. A possible reason for MDE not being accepted by robot software developers could be the wide range of applications and target platforms, which make all-encompassing MDE IDEs hard to develop and maintain. Therefore, we chose to leverage a large corpus of open-source software widely adopted by the robotics community to extract common structures and gain insight on how and where MDE can support the developers to work more efficiently. We pursue modeling as a complement, rather than imposing MDE as separate solution. Our previous work introduced metamodels to describe components, their interactions, and their resulting composition. In this paper, we present two methods based on metamodels for automated generation of models from manually written artifacts: (1) through static code analysis and (2) by monitoring the execution of a running system. For both methods, we present tools that leverage the potentials of our contributions, with a special focus on their application at runtime to observe and diagnose a real system during its execution. A comprehensive example is provided as a walk-through for robotics software practitioners.
A survey of deep meta-learning
Authors: Huisman Mike , van Rijn Jan N. , Plaat Aske 
Published: April 2021

AbstractDeep neural networks can achieve great successes when presented with large data sets and sufficient computational resources. However, their ability to learn new conceptsquicklyis limited. Meta-learning is one approach to address this issue, by enabling the network to learn how to learn. The field ofDeep Meta-Learningadvances at great speed, but lacks a unified, in-depth overview of current techniques. With this work, we aim to bridge this gap. After providing the reader with a theoretical foundation, we investigate and summarize key methods, which are categorized into (i) metric-, (ii) model-, and (iii) optimization-based techniques. In addition, we identify the main open challenges, such as performance evaluations on heterogeneous benchmarks, and reduction of the computational costs of meta-learning.
Forcing dividing cancer cells to die; low‐dose drug combinations to prevent spindle pole clustering
Authors: Ducrey Eloise , Castrogiovanni Cédric , Meraldi Patrick , Nowak-Sliwinska Patrycja 
Published: April 2021

AbstractMitosis, under the control of the microtubule-based mitotic spindle, is an attractive target for anti-cancer treatments, as cancer cells undergo frequent and uncontrolled cell divisions. Microtubule targeting agents that disrupt mitosis or single molecule inhibitors of mitotic kinases or microtubule motors kill cancer cells with a high efficacy. These treatments have, nevertheless, severe disadvantages: they also target frequently dividing healthy tissues, such as the haematopoietic system, and they often lose their efficacy due to primary or acquired resistance mechanisms. An alternative target that has emerged in dividing cancer cells is their ability to “cluster” the poles of the mitotic spindle into a bipolar configuration. This mechanism is necessary for the specific survival of cancer cells that tend to form multipolar spindles due to the frequent presence of abnormal centrosome numbers or other spindle defects. Here we discuss the recent development of combinatorial treatments targeting spindle pole clustering that specifically target cancer cells bearing aberrant centrosome numbers and that have the potential to avoid resistance mechanism due their combinatorial nature.
Nucleation behaviour and microstructure of single Al-Si12 powder particles rapidly solidified in a fast scanning calorimeter
Authors: Yang Bin , Peng Qin , Milkereit Benjamin , Springer Armin , Liu Dongmei , Rettenmayr Markus , Schick Christoph , Keßler Olaf 
Published: April 2021

AbstractThe understanding of rapid solidification behaviour, e.g. the undercooling versus growth velocity relationship, is crucial for tailoring microstructures and properties in metal alloys. In most rapid solidification processes, such as additive manufacturing (AM), in situ investigation of rapid solidification behaviour is missing because of the lack of accurate measurement of the cooling rate and nucleation undercooling. In the present study, rapid solidification of single micro-sized Al-Si12 (mass%) particles of various diameters has been investigated via differential fast scanning calorimetry employing controllable cooling rates from 100 to 90,000 K s−1 relevant for AM. Based on nucleation undercooling and on microstructure analysis of rapidly solidified single powder particles under controlled cooling rates, two different heterogeneous nucleation mechanisms of the primary α-Al phase are proposed. Surface heterogeneous nucleation dominates for particles with diameter smaller than 23 μm. For particles with diameter larger than 23 μm, the nucleation of the primary α-Al phase changes from surface to bulk heterogeneous nucleation with increasing cooling rate. The results indicate that at large undercoolings (> 95 K) and high cooling rates (> 10,000 K s−1), rapid solidification of single particle can yield a microstructure similar to that formed in AM. The present work not only proposes new insight into rapid solidification processes, but also provides a theoretical foundation for further understanding of microstructures and properties in additively manufactured materials.
Initiation of compatible wheat-Hessian fly interactions triggers the expression of a novel UDP-glycosyltransferase, MdesUGT1, in virulent Hessian fly larvae
Authors: Subramanyam Subhashree , Nemacheck Jill A. 
Published: April 2021

AbstractInsect UDP-glycosyltransferases (UGTs) play an important role in detoxification of substrates such as plant allelochemicals, and cuticle formation by the process of glucosidation. Hessian fly (Mayetiola destructor), belonging to the order Diptera (Family: Cecidomyiidae), is a destructive pest of host wheat causing significant economic losses. In the current study, using the assembled genome, we identified thirteen genes in M. destructor that belong to the family of UGTs (MdesUGT). Expression profiling revealed differential expression of MdesUGT genes in Hessian fly feeding instars. Further, we report the molecular cloning of MdesUGT1, designated as UGT301F1, from M. destructor. Characterization of the MdesUGT1 amino acid sequence revealed a conserved signature motif and sugar donor-binding domains characteristic of UGT proteins. Further expression analysis revealed dramatic increase in transcript accumulation of MdesUGT1 in the first and second feeding instars during compatible interactions (susceptible wheat, virulent larvae) but lacked significant upregulation during incompatible wheat Hessian fly interactions. Similar increase in MdesUGT1 transcripts was also observed during interactions of Hessian fly with nonhost, Brachypodium distachyon. These findings suggest the possible early involvement of MdesUGT1 in detoxification of plant toxins, and subsequent role in cuticular formation, thus contributing to the growth and development of this dipteran insect pest. Identification and characterization of insect UGTs could provide valuable insights into the detoxification and growth inhibitory mechanisms and facilitate future plant pest management strategies.
Tenascin C Promotes Glioma Cell Malignant Behavior and Inhibits Chemosensitivity to Paclitaxel via Activation of the PI3K/AKT Signaling Pathway
Authors: Zhang Qingping , Xu Binchu , Hu Fulan , Chen Xianjin , Liu Xinmin , Zhang Qinghua , Zuo You 
Published: April 2021

AbstractThe present study aimed to detect the effect of tenascin C (TNC) on cell function and chemosensitivity to paclitaxel and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling in glioma cells.Human glioma cells U87, LN-229, T98G and U251 and normal human astrocytes were obtained, in which TNC expression was detected. The U87 cells and U251 cells were chosen and infected with lentivirus of control overexpression, TNC overexpression, control knockdown, and TNC knockdown for functional experiments. Rescue experiments were then performed to evaluate the effect of PI3K/AKT activator 740 Y-P on cell function and chemosensitivity to paclitaxel in TNC knockdown U251 cells. TNC mRNA and protein expression was elevated in glioma cells, including U87, LN-229, U251 and T98G cells, compared to normal human astrocytes. In U87 and U251 cells, TNC promoted proliferation while inhibiting apoptosis. In addition, TNC upregulated PI3K and p-AKT protein expression in U87 and U251 cells. As for chemosensitivity, TNC increased relative viability in U251 cells treated with 400 ng/mL and 800 ng/mL paclitaxel. In terms of stemness, TNC increased the sphere number per 1000 cells, CD44+CD133+ cell percentage and 1/stem cell frequency (assessed by extreme limiting dilution analysis) in U251 cells. In rescue experiments, 740 Y-P reduced the effect of TNC on proliferation, apoptosis, chemosensitivity to paclitaxel, and stemness in U251 cells. TNC acts as an oncogenic factor by promoting cancer cell proliferation and stemness while inhibiting apoptosis and chemosensitivity to paclitaxel in glioma via modulation of PI3K/AKT signaling.
Gegner, Konkurrenten oder Verbündete?
Authors: Scherr Albert , Schweitzer Helmuth 
Published: April 2021

ZusammenfassungIn diesem einleitenden Beitrag wird ein Überblick zur Entwicklung der Diskussion über das Verhältnis von Polizei und Sozialer Arbeit gegeben. Dabei wird akzentuiert, dass Formen der Zusammenarbeit und wechselseitige Abgrenzungen immer wieder Gegenstand von Auseinandersetzungen waren. Zudem wird betont, dass es allzu einfach wäre, Sozialen Arbeit ein moralisch gutes Mandat der Hilfe und der Polizei ein problematisches Mandat der Kontrolle zuzuschreiben.
Compartment Syndrome: an Acute Femoral Stress Fracture in a Young Male Athlete
Authors: Kanovsky Amelie , Mueller Ernst J. 
Published: April 2021

AbstractThe incidence of an acute compartment syndrome (ACS) of the thigh is less than 1%. It is most common in the setting of muscle overuse or muscle injury, as well as secondary to trauma, such as a femoral fracture. We present a case of an ACS in a young, healthy, and semiprofessional athlete with normal coagulation who sustained an acute stress fracture of the distal femur. After the initial fracture osteosynthesis, the patient suffered from a compartment syndrome in the right anterior aspect of the distal thigh. Following rapid surgical fasciotomy, the case was uneventful, and he returned to his preinjury sport level without any neurological consequences. This case confirms that ACS in the thigh is rare, but mainly occurs in young males with a large muscle mass due to participation in various athletic programs. We hypothesize that constant muscle over-usage primes for a larger amount of contused and protruding muscle mass in the small femoral compartment. Hence, the fatigued muscle subjects the bone to an increased mechanical force resulting in an overloading process. This ensues the accumulation of femoral microfractures and primes for the occurrence of an increased rate of stress fractures and an ACS in the thigh.
Culture as Suture: on the Use of “Culture” in Cross-Cultural Studies in and Beyond Intercultural Information Ethics
Authors: Lennerfors Thomas Taro , Murata Kiyoshi 
Published: April 2021

AbstractIntercultural information ethics (IIE), a field which draws on the limits and richness of human morality and moral thinking in different societies, epochs and philosophic traditions as well as on their impact on today’s social appropriation of information and communication technology, has been argued to lack an adequate theoretical understanding of culture. In this paper, we take a non-essentialist view of culture as a point of departure and discuss not what culture is, but what we (both in our everyday lives, and as researchers) do when we use the concept of culture. To do so, we look for inspiration in the concept of suture, a concept which means the thread which stitches, or the act of stitching, a wound, but has had a long and intricate journey within psychoanalysis and film studies concerning the issue of identification. Three understandings of the use of culture emerge: suture as cultural misidentification, the evil in the cultural suture, and multiple, repeated cultural sutures. We use these categories to diagnose the use of culture in IIE and beyond, and suggest that the use of culture as multiple, repeated sutures—in other words, a recognition that we constantly fail in describing culture or cultural differences, and that each suture is coloured by its conditions of production, and that we cannot but suture with culture anyway—might be a way forward for cross-cultural research.
Forecasting Spanish unemployment with Google Trends and dimension reduction techniques
Authors: Mulero Rodrigo , García-Hiernaux Alfredo 
Published: April 2021

AbstractThis paper presents a method to improve the one-step-ahead forecasts of the Spanish unemployment monthly series. To do so, we use numerous potential explanatory variables extracted from searches in Google (Google Trends tool). Two different dimension reduction techniques are implemented (PCA and Forward Stepwise Selection) to decide how to combine the explanatory variables or which ones to use. The results of a recursive forecasting exercise reveal a statistically significant increase in predictive accuracy of 10–25%, depending on the dimension reduction method employed. A deep robustness analysis confirms these findings, as well as the relevance of using a large amount of Google queries together with a dimension reduction technique, when no prior information on which are the most informative queries is available.
Male meiosis and pollen morphology in diploid Indonesian wild bananas and cultivars
Authors: Ahmad Fajarudin , Poerba Yuyu S. , Kema Gert H. J. , de Jong Hans 
Published: April 2021

AbstractBreeding of banana is hampered by its genetic complexity, structural chromosome rearrangements and different ploidy levels. Various scientific disciplines, including cytogenetics, linkage mapping, and bioinformatics, are helpful tools in characterising cultivars and wild relatives used in crossing programs. Chromosome analysis still plays a pivotal role in studying hybrid sterility and structural and numerical variants. In this study, we describe the optimisation of the chromosome spreading protocol of pollen mother cells focusing on the effects of standard fixation methods, duration of the pectolytic enzyme treatment and advantages of fluorescence microscopy of DAPI stained cell spreads. We demonstrate the benefits of this protocol on meiotic features of five wild diploidMusa acuminatabananas and a diploid (AA) cultivar banana “Rejang”, with particular attention on pairing configurations and chromosome transmission that may be indicative for translocations and inversions. Pollen slides demonstrate regular-shaped spores except “Rejang”, which shows fertile pollen grains of different size and sterile pollen grains, suggesting partial sterility and unreduced gamete formation that likely resulted from restitutional meiotic divisions.