bluuebunny/crossref_metadata_2025_split huggingface dataset:
RESIDU ANTIBIOTIK PADA SUSU KAMBING PE YANG MENDERITA MASTITIS SUBKLINIS DI DESA AIKMUAL LOMBOK TENGAH
Authors: Iskandar Rodi 
Published: April 2021

Subclinical mastitis is a disease that often occurs in Etawa (PE) crossbreed goat farms. Farmers in handling this disease usually use antibiotics, giving antibiotics that are not right or according to the procedure can cause residues. The presence of antibiotic residues in goat's milk can have an impact on human health such as poisoning, allergies, and microbiological disorders. This study aims to determine the incidence rate and find the presence of antibiotic residues in the milk of Etawa Peranakan goat who suffer from subclinical mastitis in Aikmual Village, Central Lombok Regency. Test results from 6 samples of etawa-crossed goat milk (PE) suffering from subclinical mastitis using the Bioassay Screening Test method showed negative results containing antibiotic residues. Negative results in the sample are marked by the absence of dead bacteria on paper discs that have been soaked with milk samples from goats that are positive for subclinical mastitis, this is evident from the absence of inhibitory zones formed. The negative effect of this milk sample is due to several possibilities, namely: The stopping period of the drug has been reached and the antibiotics used are in accordance with the dose. The duration of the presence of antibiotics in milk depends on several factors, including: dose, method of administration and type of antibiotic. In general, it is applied that the withdrawal time of narrow spectrum antibiotics is at least 5 days after treatment, for the type of antibiotics that can form a depot (broad spectrum) has a withdrawal time of 1 3 days
DERAJAT INFESTASI Trichodina sp. PADA LELE DUMBO (Clarias gariepinus) DI EMPAT KOLAM PEMBUDIDAYAAN DI KABUPATEN SUMENEP
Authors: Sasmita Rochiman , Sigit Miarsono , Ro Candra Adhitya Yoppy , Hidayat Achmad Rachman 
Published: April 2021

Abstract
This research was aimed to find out the prevalence and degree of infection Trichodiniasis on the Dumbo catfish (Clarias gariepinus) in four ponds cultivation of Sumenep Regency, East Java. The total of 200 samples of Dumbo catfish were from four cultivation ponds to be examined in the Parasitology laboratory of the Faculty of Veterinary Medicine, Univercity Wijaya Kusuma Surabaya. The examination was carried out by means of scraping mucus as well as taking the gill Lamella and observed under the microscope with 100x and 400x magnification. The results showed that the highest level of Trichodiniasis prevalence was in the cultivation pool C (64%) With the degree of infection 5.62 individual parasites/fishes including the category of severe infections while in the pond cultivation A (28%) With the degree of infection 1.86 individual parasitic/fish, cultivation pool B (30%) With the degree of infection 2.46 individual parasites/fishes and the cultivation pond D (48%) With an infection degree 3.02 individual parasites/fishes including a category of mild infections. So using Uji-T can be known results of cases of Trichodiniasis that attacked Dumbo catfish (clarias gariepinus) on four pools of cultivation in Sumenep Regency, East Java showed a very noticeable difference.
DETEKSI BRUCELLOSIS PADA SAPI PERAH PERANAKAN FRIESIAN HOLSTEIN DI KECAMATAN PAGU KABUPATEN KEDIRI
Authors: Kurnianto Ady , Palgunadi Bagus Uda , Roeswandono Roeswandono , Fa’za Adilla Luthfita 
Published: April 2021

Brucellosis (Keluron disease) is a strategic infectious disease with zoonotic potential, one of which is genus Brucella abortus. This research aims to detect Brucellosis in dairy cattle FH in Pagu District, Kediri Regency. This research uses two serological tests, namely the Rose Bengal Test (RBT) and the Complement Fixation Test (CFT) with descriptive analysis method. 30 cattle blood samples were taken from the coccigea vein. The blood was set aside at room temperature to form a serum. The serum that has been obtained is taken to the Department of Food and Livestock of Kediri Regency for checking the RBT. The remaining serum obtained was sent to BBVet Wates for CFT examination. The results obtained show negative results on both tests. But one of the samples with the code S9 had gone through an abortion. This might occur due to other factors such as genetic disorders, the presence of viruses such as BVD, toxic agents and live vaccines during pregnancy.
Implementation of Regional Development Priorities Under the Conditions of the COVID-19 Pandemic
Authors: Milchakov Mikhail V. 
Published: April 2021

Due to historical features and the heterogeneity of the economic landscape, the regions of Russia are
characterized by significant disparities in the level of socioeconomic development. In order to manage
regional development, a number of important strategic documents have been adopted, including the
Spatial Development Strategy. The tasks of supporting problem regions and developing the largest
agglomerations are articulated in these documents. In the context of the pandemic, new challenges
have emerged related to slowing economic growth and budget constraints. The article examines the
specifics of the formation of individual programs for the socioeconomic development of problem
regions, as well as the situation of cities with more than 1 million inhabitants during the pandemic. The
author presents proposals for improving the measures included in the Spatial Development Strategy
ЕВОЛЮЦІЯ ЗАСОБІВ І ТЕХНОЛОГІЙ ПРОЄКТУВАННЯ ХМАРО ОРІЄНТОВАНИХ СИСТЕМ ВІДКРИТОЇ НАУКИ
Authors: Шишкіна М. 
Published: April 2021

У статті охарактеризовано основні етапи еволюції засобів і технологій проєктування хмаро орієнтованих систем відкритої науки в освіті, охарактеризовано сучасний стан проблеми, визначено перспективні напрями досліджень.
Формулювання проблеми. Необхідність дослідження обумовлена потребою підвищення рівня ІКТ компетентності вчителів закладів загальної середньої освіти України в аспекті розвитку навичок використання хмарних сервісів відкритої науки, ознайомлення їх з методологічними та методичними засадами використання сервісів даного типу в освітньому процесі.
Матеріали і методи. Для досягнення мети роботи були використані загальнонаукові методи: а) теоретичні – аналіз психолого-педагогічної літератури з проблеми дослідження; узагальнення вітчизняного і зарубіжного досвіду; теоретичний аналіз, систематизація та узагальнення наукових фактів і закономірностей б) емпіричні – анкетування; опитування; бесіди з учасниками освітньо-наукового середовища; педагогічні спостереження за начальною і науковою діяльністю суб’єктів освітнього процесу.
Результати. У роботі обґрунтовано, що запровадження хмаро орієнтованих систем відкритої науки у процес навчання і професійного розвитку вчителів є перспективним напрямом розвитку наукової освіти вчителів, що потребує удосконалення методології і методик використання засобів і сервісів відкритої науки, запровадження інноваційних форм і методів у процес навчання і наукових досліджень, розвитку ІКТ-компетентностей вчителів, зокрема, навичок здійснення наукових досліджень у співробітництві, спираючись на застосування хмаро орієнтованих засобів і сервісів підтримування наукових досліджень і опрацювання даних, розширенню частки дослідницького підходу у навчанні, поширенню кращих практик відкритої науки у вітчизняному освітньому просторі.
Висновки. Еволюція засобів і сервісів відкритої науки охоплює низку етапів: формування і розвиток науково-освітніх інформаційних мереж і інфраструктур; рух у напрямі їх уніфікації і інтеграції; виникнення Європейської хмари відкритої науки і запровадження найкращих практик її освітнього використання. Існує потреба в обґрунтуванні і запровадженні спеціально розроблених методик проєктування хмаро орієнтованих систем відкритої науки в освіті вчителів для підвищення активності і вмотивованості до наукових досліджень, поліпшення їх результативності, розвитку ІКТ-компетентності в аспекті використання хмарних технологій.
The continuity of solution set of a multivalued equation and applications in control problem
Authors: THANH  PHONG Tran , TRI Vo Viet 
Published: April 2021

In this paper, we prove the existence, unbounded continuity of positive set for a multivalued equation containing a parameter of the form $x \in A \circ F(\lambda,x)$ and give applications in the control problem with multi-point boundary conditions and second order derivative operator
\begin{equation}
\left\{
\begin{array}{l}
u^{\prime \prime }(t) +g(\lambda,t) f(u(t)) =0,\text{ }t\in (0,1) , \\
g(\lambda,t) \in F(\lambda,u(t)) \text{ a.e. on } J
\\
u(0) =0, u( 1) =\sum_{i=1}^{m}\alpha_{i} u( \eta _{i})
\end{array}
\right. \label{Eq3.1}
\end{equation}
LIPID PROFILE ABNORMALITIES IN NEPHROTIC SYNDROME
Authors: Jain Darshna , Kesarwani Anurag , Bagzai Deepasha Shahi 
Published: April 2021

Background: Nephrotic syndrome common disease in children. To study the lipid profile in nephrotic syndrome.
Methods: This is a case-control study in which 100 Normal patients and 100 patients. The Serum lipid profiles of the patients were evaluated.
Results: There was a significant increase in Total cholesterol, HDL, LDL, VLDC & TG in Nephrotic patients when compared to Controls. The study finding conclude that the serum lipid profile shoed noticeable increase in the nephrotic syndrome in Indian patients.
Conclusion: We concluded that nephrotic patients are having hyperlipidaemia. This hyperlipidaemia may progress in to the cardiovascular diseases. Hence the lipid profile in the nephrotic syndrome must be monitored for better management of the diseases.
Keywords: Lipid profile, Nephrotic syndrome, Hyperlipidemia
PENGEMBANGAN DESA WISATA DI KABUPATEN BOGOR
Authors: Dewi Liliana 
Published: April 2021

Kabupaten Bogor merupakan salah satu kabupaten terluas di Provinsi Jawa Barat, dengan luas wilayah 298, 838, 31 ha, memiliki 27 desa wisata. Desa Malasari, desa Cimande, dan desa Ciseeng merupakan tiga desa di Kabupaten Bogor yang memiliki keunikan dan menjadi sector unggulan lokal. Desa Malasari unggul dengan potensi perkebunan, desa Cimande unik akan budaya dan unggul di sektor pertanian, desa Ciseeng menjadi sentra perikanan. Tujuan penelitian ini adalah mengidentifikasi potensi wisata dari ketiga desa wisata, dan untuk merumuskan rencana strategis pengembangan desa wisata di Kabupaten Bogor. Teknik analisis data yang digunakan pada penelitian ini adalah teknik analisis data kualitatif. Pada tahap perumusan strategi pengembangan desa wisata Malasari, desa Cimande dan desa Ciseeng di Kabupaten Bogor, peneliti menggunakan teknik analisis SWOT. Hasil penelitian menunjukkan Kabupaten Bogor memiliki potensi yang dapat dikembangkan menjadi desa wisata.Â Â Â Â Kata Kunci: pariwisata, desa wisata, desa Malasari, desa Cimande, desa Ciseeng
Сучасний стан інвестиційної безпеки в Україні
Authors: Білоус В. Т. 
Published: April 2021

У статті проведено комплексне дослідження сучасного стану інвестиційної безпеки в Україні. Проаналізовано законодавчі положення нормативно-правового забезпечення інвестиційної безпеки в Україні.
Розглянуто теоретико-правові підходи щодо визначення поняття «інвестиційна безпека» та механізму забезпечення інвестиційної безпеки.
CORRELATION OF GATA-3, E-CADHERIN, P53 AND KI-67 EXPRESSION WITH HISTOLOGICAL TYPE/MOLECULAR SUBTYPE AND CLINICOPATHOLOGICAL PARAMETERS IN BREAST CANCER
Authors: ARMAN KARAKAYA Yeliz , YILMAZ Sevda 
Published: April 2021

Aims
The purpose of our study is to examine immunohistochemically the correlation of GATA binding protein 3 (GATA3), E-cadherin, p53 and Ki-67 expression with histological type/molecular subtype and clinicopathological parameters in breast cancer.
Methods and results
120 patients diagnosed with breast cancer were retrospectively investigated between 2018 May and 2021 January. We used the GATA3, E-cadherin, P53, Ki67 antibody by immunohistochemical analysis in breast tumors. GATA3 was positive in 100% (107/107) of the luminal A, luminal B and HER2 overexpressing groups and 79.9% (10/13) of the triple negative (TN) group. It is less common in the TN group (p 20% was higher in human epidermal growth factor receptor 2 (HER2) overexpressing and TN groups compared to luminal A and luminal B subtypes (p
Terapi Menulis untuk Meningkatkan Kemampuan Kognitif Pecandu Narkoba di Lapas Dewasa Kota Blitar
Authors: Aini Miza Rahmatika , Puspitasari Hesty 
Published: April 2021

Drugs is the term for narcotics, psychotropic substances and other dangerous. The term often used is DRUGS (Narcotics, Alcohol, Psychotropics and other addictive substances) Around us today, there are a lot of addictive substances that are negative and very harmful to the body. Known as narcotics and illegal drugs. In this sophisticated modern era, drugs have become a problem for mankind in various parts of the world. Drugs that can destroy bright reasoning destroy body and soul, inevitably can threaten the future of mankind. In life, a critical step of the neurodevelopmental process, drug abuse may be caused brain plasticity mechanisms that can induce long-lasting improvements in neural circuits and in the end, actions. One of the effects of these improvements is the disability. Cognitive functions, with negative academic effects on the acquisition of new information. Knowing those phenomena, the researcher had alternative therapy for increasing their cognitive functions. The researcher used writing as a therapy for them. The advantages of writing are immense, but they are also underestimated. Writing has profound therapeutic benefits. Writing is also a healthy brain exercise to activate brain cells and boost memory. This research conducted in Adult Prison in Blitar city, in which 15 drug prisoners were treated into writing theraphy. The result is they could write as well as the icreasing of their cognition.
Rekonstruksi Khilafah Dalam Al-Qur’an
Authors: Mabroer  Inwan  
Published: April 2021

This Paper examinies the views of Quraish Shihab against the arguments used by HTI and refutes the legitimacy concept khilâfah in three aspects. Firstly, the obligation to enforce Islamic law in QS. al-Mâ’idah [5]: 48. Secondly, the obligation of amar ma’ruf nahi munkar and the last is the obligation to obey with Allah, Rasul and ulil amr. Of these three foundations, Quraish Shihab sees the obligation to enforce Islamic law in the QS. al-Mâ’idah [5]: 48 deemed necessary to apply the law of God, just not to emphasize God’s law absolutely while amar ma’ruf nahi munkar in the QS. Ali ‘Imrân [3]: 110 assessed the obligation of amar ma’ruf nahi munkar related obligation invites to the good that ma’ruf in line with the value of goodness in the culture of society as well as the obligation to present doing something that can demage in QS. an-Nisâ’ [4]: 59 Quraish Shihab emphasize the obligation of obedience to Allah, Rasul and ulil Amr a daty, just only that obligation to obedient with ulil amr are those who bring a good values a mong them of the rulers/government, other meaning is ulama and the letter representing the community in these various groups and professions. In so doing, the author reters to his work “Tafsir al Misbah; Pesan, Kesan dan Keserasian Al-Qur’an” and several other works, with literary interpretation, the author review and analyze with the work of interpretive and analytical and comparative analytic approach with the interpretation of HTI.
Trace Element Signatures in Pyrite and Marcasite From Shallow Marine Island Arc-Related Hydrothermal Vents, Calypso Vents, New Zealand, and Paleochori Bay, Greece
Authors: Nestmeyer Mark , Keith Manuel , Haase Karsten M. , Klemd Reiner , Voudouris Panagiotis , Schwarz-Schampera Ulrich , Strauss Harald , Kati Marianna , Magganas Andreas 
Published: April 2021

Fluid conditions of shallow marine hydrothermal vent sites (&lt;200 mbsl) in island arcs resemble those of subaerial epithermal systems. This leads to a distinct mineralization-style compared to deeper arc/back-arc (&gt;200 mbsl) and mid-ocean ridge-related environments (&gt;2000 mbsl). At Calypso Vents in the Bay of Plenty and Paleochori Bay at the coast of Milos Island, fluids with temperatures &lt;200°C are emitted through volcaniclastic sediments in water depths &lt;200 mbsl. The hydrothermal mineralization from these fluids is dominated by pyrite and marcasite showing diverse textures, including colloform alternations, semi-massive occurrences surrounding detrital grains, vein-type pyrite, and disseminated fine-grained assemblages. Pyrite and marcasite from Calypso SE show elevated concentrations of volatile elements (e.g., As, Sb, Tl, Hg) implying a vapor-rich fluid phase. By contrast, elements like Zn, Ag, and Pb are enriched in hydrothermal pyrite and marcasite from Calypso SW, indicating a high-Cl liquid-dominated fluid discharge. Hence, vapor-liquid element fractionation induced by fluid boiling is preserved in the seafloor mineralization at Calypso Vents. Hydrothermal mineralization at very shallow vent sites (&lt;10 mbsl), like Paleochori Bay, are affected by wave action causing a seasonal migration of the seawater-fluid interface in the sediment cover. The δ34S composition of native S crusts and crystalline S (0.7–6.7‰) is indicative for host rock leaching and thermochemical reduction of seawater sulphate. By contrast, the highly negative δ34S signature of native S globules in sediments (−7.6 to −9.1‰) is related to microbial sulphate reduction or a subordinate magmatic fluid influx. Alunite-jarosite alteration (Paleochori Bay) and a mineral assemblage consisting of orpiment, realgar, and native S (Calypso Vents) may also suggest a contribution by an oxidised (sulphate-rich) low pH fluid of potential magmatic origin. However, fluid boiling is pervasive at Calypso Vents and Paleochori Bay, and the condensation of vapor-rich fluids in a steam-heated environment may produce a similar alteration and mineralization assemblage without a significant magmatic fluid influx, as known from some subaerial epithermal systems.
Peptides-Based Vaccine MP3RT Induced Protective Immunity Against Mycobacterium Tuberculosis Infection in a Humanized Mouse Model
Authors: Gong Wenping , Liang Yan , Mi Jie , Jia Zaixing , Xue Yong , Wang Jie , Wang Lan , Zhou Yusen , Sun Shihui , Wu Xueqiong 
Published: April 2021

BackgroundTuberculosis (TB) is still a global infectious disease that seriously threatens human beings. The only licensed TB vaccine Bacille Calmette-Guérin (BCG)’s protective efficacy varies significantly among populations and regions. It is very urgent to develop more effective vaccines.MethodsIn this study, eleven candidate proteins of Mycobacterium tuberculosis were selected to predict peptides with high-affinity binding capacity for the HLA-DRB1*01:01 molecule. The immunodominant peptides were identified with the enzyme-linked immunospot assay (ELISPOT) and linked in silico to result in a novel polypeptide vaccine in Escherichia coli cells. The vaccine’s protective efficacy was evaluated in humanized and wild-type C57BL/6 mice. The potential immune protective mechanisms were explored with Enzyme-linked Immunosorbent Assay (ELISA), flow cytometry, and ELISPOT.ResultsSix immunodominant peptides screened from 50 predicted peptides were used to construct a new polypeptide vaccine named MP3RT. After challenge with M. tuberculosis, the colony-forming units (CFUs), lung lesion area, and the number of inflammatory cells in humanized mice rather than wild-type mice vaccinated with MP3RT were significantly lower than these in mice immunized with PBS. The humanized mice vaccinated with MP3RT revealed significant increases in IFN-γ cytokine production, IFN-γ+ T lymphocytes, CD3+IFN-γ+ T lymphocytes, and the MP3RT-specific IgG antibody.ConclusionsTaken together, MP3RT is a promising peptides-based TB vaccine characterized by inducing high levels of IFN-γ and CD3+IFN-γ+ T lymphocytes in humanized mice. These new findings will lay a foundation for the development of peptides-based vaccines against TB.
Incidental Unruptured Intracranial Aneurysms Do Not Impact Outcome in Patients With Acute Cerebral Infarction
Authors: Wu Xuan , Duan Zuowei , Liu Yihui , Zhou Changwu , Jiao Zhiyun , Zhao Yi , Tang Tieyu 
Published: April 2021

Background: This study was to examine the patients with acute cerebral infarction (ACI) treated at a single center over 9 years and who underwent Unruptured intracranial aneurysm (UIA) screening by three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA), and to explore the factors associated with outcomes.Methods: The outcome was the modified Rankin scale (mRS) score at 90 days after stroke onset. The outcome was classified into a good outcome (mRS score of 0–2 points) and poor outcome (mRS score of 3–6 points).Results: UIAs were found in 260 (6.5%) of 4,033 patients with ACI; 2,543 (63.1%) had a good outcome, and 1,490 (36.9%) had a poor outcome. There was no difference in outcomes between the two groups (P = 0.785). The multivariable analysis showed that age (OR = 1.009, 95%CI: 1.003–1.014, P = 0.003), diabetes (OR = 1.179, 95%CI: 1.035–1.342, P = 0.013), ischemic stroke history (OR = 1.451, 95%CI: 1.256–1.677, P &lt; 0.001), and baseline NIHSS score (OR = 1.034, 95%CI: 1.018–1.050, P &lt; 0.001) were independently associated with the 90-day outcomes in patients with ACI. The presence of incidental UIA was not associated with outcomes after ACI.Conclusions: Age, diabetes, ischemic stroke history, and baseline NIHSS score were independently associated with the early outcomes of patients with ACI.
Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease
Authors: Wong Joshua K. , Hu Wei , Barmore Ryan , Lopes Janine , Moore Kathryn , Legacy Joseph , Tahafchi Parisa , Jackson Zachary , Judy Jack W. , Raike Robert S. , Wang Anson , Tsuboi Takashi , Okun Michael S. , Almeida Leonardo 
Published: April 2021

Background: Freezing of gait (FOG) is a common symptom in Parkinson’s disease (PD) and can be difficult to treat with dopaminergic medications or with deep brain stimulation (DBS). Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation (BCDBS) delivers current in various frequencies of bursts (e.g., 4, 10, or 15 Hz), while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy.