bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intertekstualitas dalam Puisi Arab: Puisi al-Ḥallāj dan Fārūq Juwaydah
Authors: Hasibuan Sammad 
Published: August 2021

This study aims to reveal the intertextual found between al-Ḥallāj’s poem (qaṣīdah) and Faruq Juwaidah’s wa Tāba al-Qalb poem. In this case, it refers to the basic assumption of intertext studies, namely that the texts or works that appear today are inseparable from the influence and role of the works that previously existed long before. Furthermore, in intertextual studies, old works that are used as a reference in making new works are called hypograms, while new works written by new authors that appear later are called transformational works. The method in this research is using descriptive analysis method. While the approach used is intertextual. Based on the results of the intertextual analysis conducted by researcher on qaṣīdah al-Ḥallāj and wa-Tāba al-Qalb poem, the researchers found (1) wa-Tāba al-Qalb poem is a form of transformation of qaṣīdah al-Ḥallāj, (2) wa-Tāba al-Qalb poem is the response from qaṣīdah al-Ḥallāj. The results of this study indicate that the impact or influence of old literary works on those that emerged later was very strong.
Hydrological Cycle of the Mediterranean-Black Sea System
Authors: García-García David , Vigo Isabel M. , Trottini Mario , Vargas Juan A. , Sayol Juan-Manuel 
Published: August 2021

Abstract
The Mediterranean-Black Sea system consists of two semi-enclosed basins connected by the Turkish Straits. In turn, the Mediterranean Sea is connected to the Atlantic Ocean through the narrow Strait of Gibraltar. The hydrological cycle of the system is driven by fresh water exchanges between the atmosphere, continents and oceans, and by salty water mass exchange among the ocean basins. Monitoring such water fluxes, especially its time evolution, is essential to understand the water cycle in the region, which is very sensitive to global climate changes and influences the variability of the Atlantic Meridional Overturning Circulation (AMOC), which in turn affects the global climate. In this study, we have estimated the hydrological cycle of the Mediterranean-Black Sea system from the time-variable gravity observations performed by the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On satellites, and precipitation and evaporation from ERA5 atmospheric reanalysis data for the period 2002-2020. In the Black Sea, rivers introduce an average water volume of 391±12 km3/year, one third of which escape through the atmosphere and two thirds go to the Mediterranean Sea. In the latter, 1787 ± 23 km3/year are lost via net evaporation. The rivers runoff (502 ± 27 km3/year), and the inflow of Atlantic waters (1020 ± 56 km3/year; 0.0323 ± 0.0018 Sv), finally restore the Mediterranean water budget. The balance is not reached instantaneously, and this delay introduces a seasonal variability in all the fluxes. In particular, the net water flux from the Atlantic Ocean increases up to 2660 ± 111 km3/year in August/September, and reverses to – 407 ± 140 km3/year in April/May. On top of the climatology, the mean annual Atlantic water flux varies significantly between 706 and 1262 km3/year.
Association Between Occupational or Environmental Noise Exposure and Renal Function Among Middle-aged and Older Korean Population: A Cross-sectional Study
Authors: Kim You Jin , Choi Won-Jun , Ham Seunghon , Kang Seong-Kyu , Lee Wanhyung 
Published: August 2021

Abstract
Exposure to occupational and environmental noise is closely linked to various diseases of auditory system. Few studies have focused on noise exposure effect on extra auditory system especially, urinary system. This study analyzed 17,202 participants aged 40–79 years from the Korea National Health and Nutrition Examination Survey between 2013 and 2018. A self-reported questionnaire was used to assess occupational or environmental noise exposure. Logistic regression was used to determine the differences in chronic kidney disease (CKD) prevalence considering noise exposure characteristics. For participants with noise exposure, linear regression was performed to determine the noise exposure period and estimated glomerular filtration rate (eGFR). In the noise exposure group, a higher CKD prevalence was associated with females who experienced long-term occupational noise (≥ 240 months), compared with the other groups (Adjusted OR = 2.86, 95% CI: 1.18–6.94). An increase of one month of occupational noise exposure was associated with a 0.0096 mL/min/1.73 m2, 0.0080 mL/min/1.73 m2, and 0.0159 mL/min/1.73 m2 decrease of eGFR in total, in males, and in females, respectively. Our results suggest that noise exposure can be a risk factor for reduced renal function, especially long-term exposure to occupational noise. More precise studies are necessary to determine the relationship between noise and renal function and the underlying mechanisms.
Antineoplastic agents associated with the development of drug-induced pancreatitis
Authors: Arablinskiy N. A. , Ostroumova O. D. , Filippova A. V. 
Published: August 2021

The frequency of drug-induced pancreatitis (LIP) is from 2 to 5% of all cases of acute pancreatitis (OP), but it is much more common in risk groups – among children and HIV-infected patients. The use of a number of drugs (drugs) is associated with the development of lipids, among them a special place is occupied by antitumor drugs due to the great medical and social significance of oncological diseases and the appearance in recent years of a large number of new antitumor drugs. The purpose of this review was to review the literature data on antitumor drugs, the use of which is associated with the development of lipids. LI OP developed in 1.8% of patients treated with nivolumab or pembroluzumab. In total, in 14 phase 1-3 studies on the efficacy and safety of ipilimumab, the development of OP was reported in less than 1% of the subjects. Therapy with molecular-targeted targeted drugs, such as tyrosine kinase inhibitors (TKI) or other representatives of the kinase inhibitor class, is also associated with the development of OP. The HP database of the World Health Organization (WHO, World Health Organization Adverse Drug Reaction database) contains reports of individual clinical cases of OP development during treatment with proteosome inhibitors and antibody-drug conjugates. It is known that the following antitumor drugs are also associated with the development of pancreatitis: 6-mercaptopurine, L-asparaginase, tamoxifen, cisplatin, cytarabine, ifosfamide, paclitaxel, docetaxel, oxaliplatin, capecitabine, periwinkle alkaloids, cytosine, cisplatin, interferon alpha-2b, doxorubicin, tamoxifen, gefitinib, vinorelbine, levamizole, methotrexate, 5-fluorouracil, capecitabine, trans-retinoic acid.
Case report of partial response on second line with Ramucirumab and FOLFIRI in treatment of 74 year old male with metastatic HER2-negative gastric adenocarcinoma
Authors: Besova N. S. , Titova T. A. , Kalinin A. E. , Shalenkov V. A. , Stilidi I. S. 
Published: August 2021

According to the data of the world statistics, gastric cancer (GC) occupies the 5th place by morbidity and the 3rd one by mortality among malignant neoplasms. A significant proportion of patients are elderly patients, the proportion of which in real clinical practice can reach up to 60%. Ramucirumab is among the standards of second-line drug therapy both in monotherapy and in combination with paclitaxel. The feasibility of prescribing ramucirumab to patients with disseminated cancer of the elderly and its satisfactory tolerability is shown in a subgroup analysis of the REGARD and RAINBOW studies. The use of paclitaxel, included in the standard first-line regimens, may be limited by persistent neurotoxicity, a side effect of platinum derivatives. In this regard, the effectiveness of the combination of ramucirumab with the FOLFIRI regimen as a second-line therapy began to be studied. The article presents a clinical case of achieving a partial effect on the second-line therapy with ramucirumab with FOLFIRI regimen in a 74-year-old patient with HER2-negative gastric adenocarcinoma while registering rapid progression after 4 courses of first-line chemotherapy in XELOX regimen. Tolerability of the second line was acceptable: asthenia grade 1, stomatitis grade 1-2, neutropenia grade 3 were observed, so the irinotecan dose was reduced to 165 mg/m2. By June 2021, there were 10 28-day cycles of treatment, which is ongoing. The duration of disease control in the second line therapy was 11+ months, of which 9+ months – on the background of FOLFIRI regimen drug therapy with ramucirumab.
Mechanisms of metastasis and development of resistance to therapy in breast cancer. A clinical case of the effectiveness of ixabepilone in hormone-receptorpositive breast cancer with multidrug resistance
Authors: Stukan A. I. , Goryainova A. Y. , Sharov S. V. , Andreev D. V. , Lymar E. V. 
Published: August 2021

Metastatic breast cancer occupies a leading position in the structure of mortality among women with oncological diseases worldwide. At the same time, the control of metastatic disease remains a significant problem for clinical oncology despite the improvement of early screening indicators, as well as the introduction of targeted therapy in clinical practice. An increase in the tumor stemness and the epithelial-mesenchymal transition in the primary tumor leads to the plasticity of the tumor cell. This is realized in the progression of the disease, resistance to the therapy and the appearance of distant metastases. Numerous signaling pathways, including PI3K/APK, STAT3, Wnt, Hedgehog, and Notch, play a key role in maintaining cellular plasticity in breast cancer. Understanding the cellular mechanisms of breast cancer cell plasticity with the development of multidrug resistance is a prerequisite for the development of effective therapeutic strategies against metastatic breast cancer in late-line therapy. The article presents an overview of the current understanding of the biological mechanism of the metastatic cascade and resistance to therapy. It is from the point of view of the plasticity of the tumor cell and the increase in the stemness of the tumor that the resistance to treatment is considered. The effectiveness of the representative of Ixabepilone was analyzed in the case of its use in the late-line therapy of hormone-receptor-positive breast cancer with multidrug resistance.
Experience of treatment of a patient with non-small cell lung cancer with met exon 14 skipping
Authors: Mandrina M. O. , Breder V. V. , Ivanov M. V. , Lebedeva A. A. , Gorbatsevich V. V. , Laktionov K. K. , Kononets P. V. 
Published: August 2021

Personalized therapy is starting to play an increasing role in modern approaches to the treatment of oncological diseases. The previously existing uniform standard for each malignant disease is expanded with new options and treatment possibilities, depending on each specific clinical situation. That increases the effectiveness of therapy and helps to control the disease. A separate niche in the individual approach to anti-tumor treatment is occupied by targeted therapy of malignancies. There are a lot of mutations that can lead to the emergence of malignant neoplasms. So of all that multitude of choices the individual approach to a patient helps to select the mutations that are most likely to be found in a given patient. The research in the area of the c-MET mutation has allowed it to occupy its niche as a therapeutic target. The identification of this mutation is not included in the routine set of analyses performed for a patient with diagnosed lung adenocarcinoma. But expanding the panel of molecular testing would increase the detectability of this mutation and, as a result, improve the quality of treatment for this category of patients. This clinical case describes the experience of treatment of an elderly patient with lung adenocarcinoma, in whose tumor tissue a MET mutation was detected.
Immunotherapy in elderly patients
Authors: Lyadova M. A. , Lyadov V. K. 
Published: August 2021

In the recent years the growing life expectancy of the population and increasing cancer burden in elderly patients substantiate the urgent need for the search of optimal cancer treatment strategies. This article provides an overview of the current literature on the efficacy and safety of checkpoint inhibitors in the elderly population. A literature search for published studies using Medline (PubMed) and Elibrary databases was performed. All studies containing data on treatment results including tumor response criteria, treatment response rate, tumor control rate, overall survival were included. Case studies, animal studies and studies containing duplicate results were excluded from the analysis. In elderly patients with cancer there is a substantial number of comorbid conditions and functional disorders, which may decrease the efficacy and modulate the tolerability of immune checkpoint inhibitors (ICI). Besides, different changes associated with immunologic ageing, including thymolysis, increase of the number of memory B-cells and a decrease of hematopoesis intensity are observed. Several studies performed a comparative analysis of efficacy and toxicity of ICIs in elderly and younger patients. In most cases similar results for efficacy and toxicity were demonstrated. To evaluate the toxicity and the influence of treatment on functional status and other important measures in geriatric population further studies of factors, influencing the tolerability and treatment response of newer ICI in elderly cancer patients are needed, including additional adverse events associated with treatment.
Erlotinib: How to increase the duration of effective use of tyrosine kinase inhibitors in non-small cell lung cancer with EGFR mutation
Authors: Borisova E. I. , Gutorov S. L. 
Published: August 2021

Tyrosine kinase inhibitors of the first, second and third generations are the main treatment method for non-small cell lung cancer with EGFR mutation. About 60% of patients progressing on a first-generation or second-generation tyrosine kinase inhibitor acquire T790M mutation. An alternative is first-line osimertinib, but second-line treatment options are limited, and therefore it is important to find a strategy that allows to extend the effective treatment of TKI. One of the rational approaches is the use of a combination of a first-generation tyrosine kinase inhibitor with anti-VEGF agents. The available information sources show an increase in the effectiveness of the combined use of erlotinib and antiangiogenic drugs-bevacizumab and ramucirumab. The combination of erlotinib and bevacizumab in several studies of the second — third phase, led to a statistically significant increase in progression-free survival, but did not show a significant increase in overall survival. In the Phase 3 RELAY study, the combination of erlotinib and ramucirumab showed comparable efficacy with the third-generation TKI — osimertinib in the first line, however, overall survival results are not yet available. At the same time, there are more opportunities to choose the secondline mode, taking into account the known frequency of detection of the T790M mutation. The optimal treatment sequence is discussed, with the option of prescribing a combination of erlotinib with bevacizumab or ramucirumab in the first line and osimertinib in the second in the presence of the T790M mutation. In such patients, osimertinib may be prescribed in the second line.
The role of immunotherapy in the management of metastatic/recurrent female reproductive system neoplasms
Authors: Rumyantsev A. A. , Anokhin A. Yu. 
Published: August 2021

In 2019 malignant neoplasms of the female reproductive system (ovarian cancer, (OC), endometrial carcinoma (EC) and cervical cancer (CC) were diagnosed in 58 860 patients – 17.6% of all malignant tumors in women in Russia. The morbidity and mortality rates from these neoplasms remain high over the past 10 years. This article provides a detailed review of the current evidence base for the use of various immunotherapeutic agents in mentioned malignant neoplasms. It has been demonstrated that in relapsed OC (ROC), the only proved indication for immunotherapy is tumors with microsatellite instability (MSI), whereas PD-L1 does not have an independent role in this disease. MSI occurs in approximately 8% of patients with metastatic OC. A significantly higher frequency MSI — up to 25% is detected in metastatic EC. MSI-positive subtype of the disease is characterized by an extremely high sensitivity to immunotherapy - the rate of objective response with pembrolizumab exceeds 50%. For MS-stable EC, the combination of pembrolizumab and lenvatinib is an effective therapeutic option. In advanced CC, on the other hand, PD-L1 has a predictive role for immunotherapy efficacy — the KEYNOTE-158 study showed that about 15% of patients with extensively pretreated metastatic PD-L1-positive CC can achieve long-term remission with pembrolizumab compared to 0% in PD-L1 negative tumors. Current evidence shows that PD-L1 expression can be observed in ≥ 30% of patients.
Pengembangan media pembelajaran tajwid berbasis aplikasi Android
Authors: Nadawiyyah Hilyatun , Anggraeni Dewi 
Published: August 2021

Penelitian ini bertujuan untuk: 1.) Menganalisis kebutuhan pengembangan aplikasi android pada mata pelajaran Pendidikan Agama Islam materi tajwid; 2.) Mendesain aplikasi android pada mata pelajaran Pendidikan Agama Islam materi tajwid; 3.) Menganalisis pengembangan aplikasi android pada mata pelajaran Pendidikan Agama Islam materi tajwid; 4.) Menganalisis implementasi aplikasi android pada mata pelajaran Pendidikan Agama Islam materi tajwid; dan 5.) Menganalisis evaluasi aplikasi android pada mata pelajaran Pendidikan Agama Islam materi tajwid. Model penelitian dan pengembangan yang digunakan yaitu model pengembangan ADDIE. Hasil penelitian ini menunjukan bahwa berdasarkan analisis kebutuhan peserta didik, kurikulum, materi dan media, desain media berdasarkan pada penyesuaian dengan karakteristik peserta didik dan berdasarkan pada materi yang dipelajari, pengembangan media berdasarkan pada uji validitas yang dilakukan dengan ahli media dan ahli materi, implementasi berdasarkan uji coba terhadap guru dan peserta didik, evaluasi berdasarkan pada evaluasi formatif dan sumatif menunjukkan bahwa penggunaan media pembelajaran tajwid berbasis aplikasi android sangat layak digunakan sebagai media pendukung pada pembelajaran PAI materi tajwid. Development of Tajwid learning media based on Android applicationAbstractThis study aims to: 1.) Analyze the needs of developing android applications on Islamic Religious Education subjects recitation; 2.) Designing android applications on Islamic Religious Education subjects recitation; 3.) Analyzing the development of android applications on Islamic Religious Education subjects Tajweed; 4.) Analyze the implementation of Android applications on Islamic Religious Education subjects Tajweed material; and 5.) Analyze the evaluation of Android applications on Islamic Religious Education subjects Tajweed material. The research and development model used is the ADDIE development model. The results of this study indicate that based on the analysis of student needs, curriculum, materials, and media, media design is based on adjustments to the characteristics of students and based on the material being studied, media development is based on validity tests conducted with media experts and material experts, implementation is based on trials on teachers and students, evaluation based on formative and summative evaluations shows that the use of Tajweed learning media based on Android applications is very feasible to be used as a supporting medium in the learning of Tajweed Tajweed material.
Peningkatan model SAMR serta penerapannya untuk pembelajaran online yang mendalam
Authors: Alfiana Herlia 
Published: August 2021

Pelaksanaan e-learning menjadi desakan solusi untuk dapat menyampaikan pembelajaran di tengah pandemi. Pelaksanaan e-learning sangat mengandalkan pemanfaatan teknologi. Hal ini menjadi tantangan baru karena ketidaksiapan pendidik karena keterbatasan literasi digital dan sulitnya menentukan teknologi yang akan digunakan dalam pembelajaran. Untuk mengatasi permasalahan tersebut, penerapan model SAMR (Substitution, Augmentation, Modification, Redefinition) menjadi sebuah solusi. Model SAMR banyak diterapkan oleh praktisi pendidikan karena jelas, sederhana, dan mudah diadaptasi. Namun, model SAMR memiliki tiga kritik untuk peningkatan. Penelitian ini merupakan penelitian literature review yang menggunakan metode PRISMA systematic review. Kajian pada penelitian ini menjawab tantangan perbaikan pada penerapan model SAMR dalam pembelajaran dan mengkaji kesesuaian model SAMR untuk diterapkan pada e-learning yang syarat akan pemanfaatan teknologi dan bagaimana mewujudkan e-learning yang mendalam.SAMR model improvement challenge and application for deeper online learningAbstractE-learning becomes an urgent solution to be able to deliver learning in the midst of a pandemic. The implementation of e-learning relies heavily on technology integration. This is a new challenge for educators due to the unpreparedness, the limitations of digital literacy, and the difficulty in determining the appropriate technology in e-learning. In order to overcome these problems, the application of the SAMR model (Substitution, Augmentation, Modification, Redefinition) is one of the solutions. Education practitioners have widely applied the SAMR model because of its clarity, simplicity, easiness, and adaptability. However, the SAMR model has three drawbacks that can be improved. This study answers the challenge in improving the application of the SAMR model in learning and assessing the suitability of the SAMR model applied to e-learning which requires technology.
The effect of empathy to bystander's role towards bullying at school through moral disengagement as a mediator
Authors:   Department of Psychology, Faculty of Psychology and Socio-Cultural Sciences, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia, Gholiyah Yayah Durrotul , Nashori H. Fuad , Diana Raden Rachmy ,   Department of Psychology, Faculty of Social Sciences and Humanities, Universitas Islam Negeri Sunan Kalijaga,Yogyakarta55281, Indonesia
Published: August 2021

This study aims to illustrate the effect of empathy on the role of the bystander towards bullying at school through moral disengagement as the mediator. Moral disengagement affects bystanders' role. In this case, an outsider or ignorant bystander indicates higher moral disengagement than a defender or defensive bystander. The subject were 245 high school students in the age of 15-17 years. The respondents acted as bystanders adapted from the Participant Role Questionnaire (PRQ) scale. The researcher adopted the Basic Empathy Scale dan Moral Disengagement Scale as the measuring instrument. The data analysis employed a simple mediation analysis technique with bootstrapping method. The results indicated that first, there was a positive and significant effect of empathy on the role of defender bystander mediated by moral disengagement. Second, there was a negative and significant effect of empathy on reinforcer bystander's role towards bullying at schools as mediated by moral disengagement. Third, the study also indicated that there was no effect of empathy to the bystander's roles as an assistant, outsider, and aggressive defender through moral disengagement as a mediator. One of implications for future interventions in schools, for instance, bystander training emphasizing an effective way to act towards bullying at school.