bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Usia dan Jenis Kelamin pada Skala Nyeri Pasien Trigeminal Neuralgia
Authors: Hidayati Hanik Badriyah , Amelia Elena Ghentilis Fitri , Turchan Agus , Rehatta Nancy Margarita , Atika  , Hamdan Muhammad 
Published: November 2021

Pendahuluan: Trigeminal neuralgia (TN) merupakan kondisi yang digambarkan sebagai nyeri hebat seperti tersilet pada satu sisi wajah pada distribusi area saraf ke lima. Nyeri ini dapat mengganggu aktivitas sehari-hari pasien. Rasa nyeri merupakan fenomena subjektif yang dapat dipengaruhi oleh banyak faktor, seperti usia dan jenis kelamin. Tujuan: Mengetahui pengaruh usia dan jenis kelamin terhadap skala nyeri pasien Trigeminal Neuralgia. Metode: Data diambil dari rekam medik pasien pada periode Januari 2017 hingga Juni 2019 di RSUD Dr. Soetomo Surabaya, RS PHC Surabaya, dan RSUD Bangil Pasuruan berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil: TN banyak ditemukan pada kelompok usia 36-64 tahun (55,55%) dan jenis kelamin perempuan (66,67%). Tidak didapatkan hubungan pengaruh usia dan jenis kelamin terhadap skala nyeri pasien (p > 0.05). Kesimpulan: Usia dan jenis kelamin merupakan faktor yang tidak dapat diubah dalam mempengaruhi nyeri. Usia dan jenis kelamin mempengaruhi nyeri melalui perubahan anatomi, hormonal, dan psikologis. Tidak ada hubungan antara usia dan jenis kelamin pada skala nyeri pasien dengan TN.
DIGITAL TWIN OF GAS RECIPROCATING COMPRESSOR UNIT: CONCEPT, ARCHITECTURE & PILOT IMPLEMENTATION
Authors: Prokhorenko А. , Kravchenko S. , Solodkii E. 
Published: November 2021

Combination of information and operational technologies has led to a new way of production, to a new technological revolution, known as Industry 4.0. The Digital Twin plays a central role in this technology. The Digital Twin is a predictive maintenance tool, and allows you to simulate various options for device failures taking into account their operation modes, environmental influences and various degrees of wear. The concept of creating a digital twin of a real physical object of research is proposed - an AJAX DPS-180 internal combustion engine with a gas piston compressor, which is designed to pump gas from gas wells. A feature of its work is autonomous long-term operation in the field with the remoteness of the service personnel, direct environmental impact and ensuring the reliability and stability of work. Therefore, monitoring the parameters of the engine with the subsequent prediction of its failures is especially important. The work on creating a digital twin for AJAX DPS-180 is being carried out in cooperation and with the support of Armco-Engineering, the operator of this equipment.
Six stages of the process of creating a digital twin of a given object are shown: collection and preliminary processing of data on the technical state of a real object; early detection of malfunctions, predicting the time of failure; service planning; optimization of financial and time resources for service. Equipping a real object with various sensors made it possible to continuously collect data on its technical condition, and technologies of the industrial Internet of things, such as Big Data and the predictive statistical model, predict failure times with high accuracy.
The developed and implemented schemes for equipping an object with data collection equipment and a diagram of the flow of this data in the Internet of Things are presented. The basis of the data collection system is a microcontroller, a set of a crankshaft speed sensor and thermocouples, a multiplexer and 16-bit analog-to-digital converters that convert thermo-EMF of thermocouples. At the moment, channels for measuring the speed, coolant and exhaust gas temperatures have been implemented. It is proposed to use the ThingSpeak server as a remote resource as a cloud aggregator and carrier of this data. The MATLAB mathematical package integrated into the resource is used as a data analyzer.
the THE EFFECT OF STAD TYPE COOPERATIVE LEARNING MODEL ON THE LEARNING OUTCOMES OF VIHARA DHAMMAPHALA SUNDAY SCHOOL- TANGERANG
Authors: Dhamayanti Wina , Sutikno Dendang 
Published: November 2021

Penelitian ini dilakukanberdasarkan nilai hasil belajar SMB Vihara Dhammapala tergolong rendah. Rendahnya hasil belajar dikarenakan beberapa faktor salah satunya model pembelajaran yang kurang efektif maka dari itu dengan adanya model pembelajaran Student Teams Achievement Divisions (STAD) merupakan salah satu model pembelajaran kooperatif yang di dalamnya terdapat beberapa kelompok peserta didik dengan level kemampuan akademik berbeda-beda yang kemudian bekerjasama untuk merealisasikan tujuan pembelajaran. Penelitian ini bertujuan untuk dapat mengetahui pengaruh model pembelajaran kooperatif tipe STAD terhadap hasil belajar peserta didik Sekolah Minggu Vihara Dhammaphala. Desain yang digunakan dalam penelitian berbentukeksperimen dengan pendekatan kuantitaif. Instrument yang digunakan dalam penelitian ini adalah angket, dokumen dan wawancara. Angket disebarkan kepada 20 peserta didik. Data yang telah diperoleh dari penyebaran angket dianalisis menggunakan skala likert dan hasil belajar pretest posttest dianalisii menggunakan uji t berpasangan. Hasil penelitian ini menunjukan bahwa model pembelajaran STAD berpengaruh sangat kuat terhadap hasil belajar agama Buddha, jika ditinjau dari persen capaian sebesar 91,75% kemudian dari jawaban evaluasi respon dengan skor total 1468 dan persen capaian 91,81%. Selanjutnya berdasarkan uji t berpasangan nilai before dan after Sekolah Minggu Vihara Dhammaphala dengan skor 14,82 ternyata berpengaruh sangat nyata dengan selisih rata-rata 17,55. Maka model pembelajaran STAD sangat meningkatkan nilai hasi belajar SMB Vihara Dhammaphala.
Evaluation of the Success Rate of Emergency Cerclage by Double- Suture Method in Pregnant Women With the Prolapsed Amniotic Membrane
Authors: Emami Ali , Dadashaliha Masumeh 
Published: November 2021

Abstract
BackgroundCervical insufficiency is a risk factor for preterm labor and second trimester loss. Cervical cerclage is the choice treatment for women with this risk factor. An emergency cerclage is recommended in cases with the prolapsed amniotic membrane at the dilated cervical os before 24 weeks of gestation. The aim of this study is to report our method with double-suture in emergency cerclage. MethodsThis is a cross-sectional study conducted between March 2017 and February 2019 of women who received the double-suture cerclage in Qazvin referral Kosar hospital. The inclusion criteria were women with gestational age of 18-24 weeks with the prolapsed amniotic membrane and cervical dilatation (more than 3-4cm) in the speculum exam. The exclusion criteria were the mother's dissatisfaction to do this cerclage, previous failure cerclage, twin pregnancy, preterm rupture of membrane (PROM) signs and chorioamnionitis signs.ResultsFive women were included. All of them presented prolapsed membranes at or beyond the cervical os. The double-suture cerclage was performed for all of the patients. All of women delivered by normal vaginal delivery and their infants had no problems. ConclusionsDespite the small number of the patients, this study showed that this method of cerclage was effective in pregnancy for women with high risk of preterm labor and second trimester loss. This technique requires an expert and trained surgical team. The following studies should be performed with a big population and compare with other methods of emergency cerclage.
Association Between the Diabetes Drug Cost and Cardiovascular Events for Type 2 Diabetes in Korea: A National Health Insurance Service Database Analysis
Authors: Chung Seung Min , Lee Ji-In , Han Eugene , Seo Hyun-Ae , Jeon Eonju , Kim Hye Soon , Yoon JiSung 
Published: November 2021

Abstract
Background: We aimed to investigate the long-term effects of diabetes drug costs on cardiovascular (CV) events and death. Methods: This retrospective observational study used the 2009–2018 National Health Insurance data in Korea. Among patients with type 2 diabetes, those who were taking antidiabetic drugs and did not have CV events before 2009 were included. Data on the annual cost of each diabetes drug were collected. The 10-year incidence of CV events (cardiac death, non-fatal myocardial infarction, stroke, hospitalization for heart failure, and coronary revascularization) and CV death were analyzed according to the diabetes drug cost quartiles (Q1 [the lowest] – Q4 [the highest]).Results: A total of 441,914 participants were enrolled (median age, 60 years; male, 57%). CV events and death occurred in 28.1% and 8.36% of patients, respectively. The overall diabetes drug cost was USD 271/year per person (range: 1–18,921). The 10-year incidence of CV events and death was lowest in Q3 and high in Q4 and Q1. After adjusting for CV risk factors, the risk of CV events increased in the sequential order of cost quartiles (hazard ratio (HR)=1 [ref], 1.102 [95% confidence interval (CI): 1.084–1.120], 1.137 [95% CI: 1.118–1.156], and 1.323 [95% CI: 1.3011.346]). The risk of CV death showed U-shaped pattern which was lowest in the Q3 (HR=0.943, 95% CI 0.903-0.984) and highest in the Q4 (HR= 1.234, 95% CI 1.182-1.287).Conclusion: The expenditure for diabetes drug affects 10-year CV events and death. Affording an appropriate diabetes cost at a similar CV risk is an independent protective factor for CV death.Trial registration: retrospectively registered
QT Interval Instability and Variability in Dogs with Hyperadrenocorticism
Authors: Vila Beatriz de Carvalho Pato , Vanhoni Marcela Sigolo , Sousa Marlos Gonçalves 
Published: November 2021

Abstract
Hyperadrenocorticism is one of the most common endocrine diseases in dogs. In humans, it is clearly associated with a higher risk of cardiovascular events, but studies in dogs are scarce. To investigate the arrhythmogenic risk of dogs with hyperadrenocorticism, indices of variability and instability of the QT interval were studied in 38 dogs with hyperadrenocorticism and in 12 healthy dogs: variance (QTv), total instability (TI), short-term (STI) and long-term (LTI), and mean (QTm). Except for QTm, all parameters studied were higher in the hyperadrenocorticism group than in the control group. In addition, STI and QTv showed moderate positive correlation with left ventricle wall thickness. To a better understanding on the effect of the hypothalamus-pituitary-adrenal axis on ventricular repolarization, the hyperadrenocorticism group was subdivided according to the percentage of variation in plasma cortisol concentration (<30.1%; 30.1-60%; >60%) 8 hours after low-dose administration of dexamethasone. There was statistical difference in QTv, TI and LTI indices between the control group and the <30.1% and >60% groups, and in STI index between the control group and the >60% group. There was no statistical difference between sex groups in any of the electrocardiographic parameters studied. This result may indicate that the etiology of hyperadrenocorticism, and its consequent influence on hypothalamus-pituitary-adrenal axis could interfere on the heterogeneity of ventricular repolarization parameters in different ways, especially in the short-term stability; however further studies are necessary to understand the role of cortisol on electrical instability in dogs.
Relationship Between Emotion Regulation and Non-suicidal Self-injury (NSSI): a Systematic Review and Meta-analysis Protocol
Authors: Taherifar Zahra , Mousavi Nasim , AghaMohammadi Soudeh , Zeinodini Zahra , Rostami Hanieh Goli , Farahani Hanieh Sh. , Norozpour Marzieh , Keshtkar Abbas 
Published: November 2021

Abstract
Background: Non-suicidal self-injury (NSSI) is recognized a serious mental disorder. Its prevalence has increased in recent years. Emotion regulation has been noted to have important role in mental health problems. There is evidence in the literature about the relationship between NSSI and emotion regulation. The studies, however, have reported mixed findings, and no comprehensive study has been conducted yet to address this topic. Therefore, the aim of this systematic review and meta-analysis is to investigate the relationship between NSSI and emotion regulation.Methods: All studies published after 1990 that have assessed the relationship between NSSI and emotion regulation will be eligible. This entails observational-analytic (descriptive or cross-sectional) studies, case-control studies, cohort studies. There will be no language restriction. Additionally, no limitation will be imposed regarding age, gender, and nationality of the subjects studiedDiscussion: Given the inconsistencies present in the findings of primary studies in terms of relationship between NSSI and emotion regulation strategies conducting such a study seems necessary. The results of this study could be used to improve our knowledge about NSSI, help revise health policies in the future, research and education to reduce NSSI burden, and to develop more effective interventions to manage NSSI.Systematic review registration: CRD42021226454
Risk Factors Associated with Dysphagia after Anterior Surgery in Treatment for Multilevel Cervical Disorder with Kyphosis
Authors: li yongjun , wei xing , Chen Bingyao , wang feng , Song Guangze , shen yong 
Published: November 2021

Abstract
Study Design: A retrospective study.Objective: The purpose of this study was to clarify the risk factors associated with dysphagia following anterior surgery treating multilevel cervical disorder with kyphosis based on subgroup of follow-up time.Methods: Totally, 81 patients who suffered from multilevel cervical disorder with kyphosis receiving anterior surgery from July 2018 to June 2020 were reviewed for clinical and radiological outcomes. Patients with dysphagia was defined as dysphagia group and without dysphagia as no-dysphagia group according to follow-up time (1 week, 1-month, 3-month, 6-month and 1-year after surgery). Data was performed to compare between the patients with and without dysphagia.Results: In our study, the occurrence of dysphagia was 67.9%, 44.4%, 34.6%，25.9% and 14.8% at the time of 1 week, 1-month, 3-month, 6-month, and 1 -year after surgery, respectively. Our findings showed that a history of smoking, lower preoperative Swallowing Quality of Life (SWAL-QOL) score, post-operative Cobb angle of C2-7 and change of Cobb angle of C2-7 were associated with dysphagia within 3-month after surgery. Furthermore, a history of smoking, lower preoperative SWAL-QOL score, and post-operative Cobb angle of C2-7 were linked with dysphagia within 6-month after surgery. However, a history of smoking and lower preoperative SWAL-QOL score were found to be risk factors related with dysphagia at at any follow-up.Conclusions: In the present study, many factors were related with dysphagia during 3-month after surgery. What’s more, a history of smoking and lower preoperative SWAL-QOL score were associated with dysphagia at any follow-up. We hope this article can provide a reference for spinal surgeons to predict which patients were susceptible to suffer from dysphagia after anterior surgery in treatment of multilevel cervical disorder with kyphosis.
Matrix Completion of World Trade
Authors: Gnecco Giorgio , Nutarelli Federico , Riccaboni Massimo 
Published: November 2021

Abstract
This work applies Matrix Completion (MC) – a class of machine-learning methods commonly used in the context of recommendation systems – to analyze economic complexity. MC is applied to reconstruct the Revealed Comparative Advantage (RCA) matrix, whose elements express the relative advantage of countries in given classes of products, as evidenced by yearly trade flows. A high-accuracy binary classifier is derived from the MC application, with the aim of discriminating between elements of the RCA matrix that are, respectively, higher/lower than one. We introduce a novel Matrix cOmpletion iNdex of Economic complexitY (MONEY) based on MC, and related to the degree of predictability of the RCA entries of different countries (the lower the predictability, the higher the complexity). Differently from previously-developed economic complexity indices, MONEY takes into account several singular vectors of the matrix reconstructed by MC, whereas other indices are based only on one/two eigenvectors of a suitable symmetric matrix, derived from the RCA matrix. Finally, MC is compared with a state-of-the-art economic complexity index (GENEPY), showing that the false positive rate per country of a binary classifier constructed starting from the average entry-wise output of MC is a proxy of GENEPY.
Microbiome Analysis Exploring Taxonomic Diversity in Kasaragod Dwarf and Holstein Crossbred Cattle
Authors: M Deepthi , Arvind Kumar , Saxena Rituja , Pulikkan Joby , Sharma Vineet K , GRACE TONY 
Published: November 2021

Abstract
The indigenous cattle are efficient in converting low quality feeds and forage into animal products. Kasaragod Dwarf cattle, a unique non-descriptive native cattle of Kerala, India, are noted for their unique qualities, such as low feed intake, thermotolerance, greater resistance to diseases and A2 allelic variant milk. However, owing to the higher milk yield, Holstein crossbred cattle are given more importance over Kasaragod Dwarf. The hindgut microbiota plays a major role in various biological processes such as the digestion, vitamins synthesis, and immunity in cattle. In this study, we compared the hindgut microbiota of the Kasaragod Dwarf with the highly found, Holstein crossbred utilizing 16S rRNA high-throughput sequencing for a better understanding of the relationship between the host and microbial community. Four replicates of each 20 samples comprising two cattle type (n=10) were sequenced and analyzed. Marker gene-based taxonomic analysis affirmed variations in their microbial composition. Principle Coordinate Analysis (PCoA) using weighted and unweighted UniFrac distance matrices showed the distinct microbial architecture of the two cattle type. Random Forest analysis further confirmed the distinctness and revealed the signature taxa in K-Dwarf. The study observed the predominance of feed efficiency associated genera viz., Anaerovibrio, Succinivibrio, Roseburia, Coprococcus, Anaerostipes, Paludibacter, Elusimicrobium, Sutterella, Oribacterium, Coprobacillus, and Ruminobacter in Kasaragod Dwarf cattle. The study highlights the abundance of unique and beneficial hindgut microflora found in Kasaragod Dwarf, which may attest its importance over exotic cattle breeds viz., Holstein. To our knowledge, this is the first report of Kasaragod Dwarf cattle gut microbiome profiling. This study is pivotal towards developing genetic resources for the microbial population in K-Dwarf and how it could be differentiated from Holstein crossbred cattle.
Circ-0010928 Negatively Regulates Hypoxia-Induced Endothelial Cell Angiogenesis Through The miR-921/LSM14A axis.
Authors: Zhang Tian Rong , Huang WeiQiang 
Published: November 2021

Abstract
Background

Angiogenesis is an important factor in promoting vascular repair and a valuable process in the treatment of cardiovascular diseases. Circular RNAs (circRNAs) are widely expressed in eukaryotic cells and play an important role in the regulation of endothelial cells (ECs). In our study, bioinformatics analysis and real-time fluorescent PCR detection revealed that circRNA 0010928 (circ-0010928) is differentially expressed in human cardiac microvascular endothelial cells (HCMECs).
Material & Methods

We evaluated the role of circ-0010928 in HCMECs. Then, we can verify the function of circ-0010928 in HCMECs by cell counting kit-8 (CCK8), scratch test, transwell experiment, tube forming experiment, flow cytometry. Use dual luciferase experiment to detect the binding relationship between circ-0010928, miR-921 and LSM14A.
Results

Overexpression of circ-0010928 inhibited the proliferation, migration and tube formation of HCMECs under hypoxic conditions and promoted their apoptosis. In addition, dual luciferase reporter assays confirmed that circ-0010928 acted as a sponge of miR-921 and LSM14A as a downstream target gene of miR-921. Silencing miR-921 could also inhibit the proliferation, migration and tube formation of HCMECs and negatively regulate angiogenesis.
Conclusion

CircRNA-0010928 may inhibit the function of miRNA-921by combining with miRNA-921, and then miRNA-921 plays a role in regulating LSM14A, thereby regulating the state of angiogenesis.
Activation of The P62-Keap1-NRF2 Pathway Protects Against Ferroptosis in Radiation-Induced Lung Injury
Authors: Li Xuan , Chen Jingyao , Yuan Sujuan , Zhuang Xibing , Qiao Tiankui 
Published: November 2021

Abstract
Background

Radiation-induced lung injury (RILI) is one of the most common, serious and dose-limiting complications of thoracic radiotherapy. A primary reason for this is the radiation-induced cell death. Ferroptosis is a recently recognized form of regulated cell death, characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). The ROS induced by irradiation might be the original trigger of ferroptosis in RILI. Furthermore, activation of the P62-Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (NRF2) pathway has been shown to exert a protective effect, blunting ferroptosis. Therefore, this study aims to explore the protective effect of the P62-Keap1-NRF2 pathway against radiation-induced ferroptosis in alveolar epithelial cells.
Results

Firstly, our results demonstrated that radiation induced ferroptosis in vitro RILI cell model, which could be significantly reduced by Ferrostatin-1 (Fer-1), a specific inhibitor of ferroptosis. Then, we found that overexpression of P62 interacted with Keap1 to promote NRF2 translocation into the nucleus and upregulation its target proteins quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO1) and ferritin heavy chain 1 (FTH1).
Conclusion

Collectively, the activation of the P62-Keap1-NRF2 pathway prevents radiation-induced ferroptosis in RILI cells, providing a theoretical basis for further research to find a potential approach for RILI therapy.