bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperbaric oxygen therapy and fluorescence angiography in arterial insufficiency secondary to injection of crushed hydromorphone
Authors:   Department of Hyperbaric Medicine, Louisiana State University, New Orleans, Louisiana U.S., Ray Kristi , Savaser Davut ,   Hyperbaric Medicine and Chronic Wound Clinic, Legacy Emanuel Medical Center, Portland, Oregon U.S., Huang Enoch ,   Hyperbaric Medicine and Chronic Wound Clinic, Legacy Emanuel Medical Center, Portland, Oregon U.S.
Published: August 2021

Introduction: Foreign body emboli can lead to acute arterial insufficiency. We present a case report of upper extremity arterial insufficiency in an intravenous (IV) drug user secondary to intra-arterial injection of crushed tablet particles successfully treated with hyperbaric oxygen (HBO2) therapy.	Case: A 37-year-old right-hand-dominant male developed pain and swelling of the left hand after attempting to inject crushed hydromorphone tablets into his venous circulation. Angiography revealed incomplete distal filling of the proper digital arteries, princeps pollicis, and radialis indicis branches of the left hand. The patient was treated with HBO2 for acute arterial insufficiency, secondary to these findings. Fluorescence angiography was performed prior to, during and after completion of HBO2, which showed improved perfusion of the hand upon completion of serial imaging. The patient underwent subsequent partial amputation of the left second digit and removal of the thenar and third finger pads.	Discussion: Much of the literature on treatment of arterial insufficiency with HBO2 are in relation to chronic problem wounds. However, there is limited data on adjunctive treatment with HBO2 for foreign body embolism. Fluorescence angiography and clinical exam were used to track tissue perfusion and progression throughout course of therapy with HBO2.	Conclusion: Acute arterial insufficiency induced by foreign body embolism was successfully treated with HBO2 and provided increased tissue salvage of the patient’s hand. The use of fluorescence angiography as a secondary measure of perfusion can provide additional insight regarding qualitative tissue oxygenation and may be a viable tool to track patient progress during HBO2 treatment.
As Ações de Informação e seus contextos: aportes da pragmática ao campo investigativo da Ciência da Informação
Authors: González de Gómez Maria Nélida 
Published: August 2021

Estudos anteriores indicam que existem elos, implícitos e explícitos, entre as micro regras das ações informacionais, singulares, situadas, e as macro regras da economia, da administração, da política. Hoje, a expansão dos dispositivos e ambientes digitais, gera novas questões sobre as relações que se estabelecem entre ações locais e situadas, e ações informacionais de outra ordem e extensão, implementadas nos ambientes digitais. Neste trabalho, procura-se melhor entender o que constitui o contexto das ações de informação, e como ele se modifica (ou não), conforme se modificam as condições culturais e tecnológicas em que estão ancoradas. Recorremos para isso aos quadros conceituais das abordagens pragmáticas, e a estudos socioantropológicos que ilustram as mudanças na função, efeitos e relevância dos contextos das ações de informação.
Palavras-chave: Ações de informação. Contextos. Situações sintéticas.
A Probabilidade de Negociações Informadas (PIN) versus Disclosure de Negociações dos Insiders: o Caso da JBS S.A. (JBSS3) com Modelos de High-Frequency Trading
Authors: Nóbrega Pordeus Glauco Graco , Pontes Girão Luiz Felipe de Araújo , Coelho de Lima Duarte Filipe 
Published: August 2021

Objetivo: Este trabalho tem como objetivo principal identificar operações de compra ou venda no ativo JBSS3, da empresa JBS S.A., e introduzir uma metodologia de análise de operações com base na proxy de informação assimétrica captada pela métrica de Probabilidade de Negociações Informadas (PIN). Metodologia: A JBS S.A. é usada como caso de análise nesta pesquisa pois foi o 1º caso de prisão por insider trading no Brasil. Desta maneira, foram usados modelos matemáticos para a estimação da PIN para verificar se era possível se antecipar aos movimentos de uma pessoa com acesso a informações privilegiadas. Principais resultados: Os resultados encontrados apontam que a) o relatório obrigatório e mensal exigido pelo órgão regulador do mercado de capitais é pouco útil para proteger o investidor brasileiro, b) que mesmo com um modelo matemático avançado, não foi possível (em partes) obter retorno anormal antecipando as operações dos insiders, mas c) o modelo matemático da PIN gerou melhores resultados do que o relatório exigido pelo regulador. Contribuições acadêmicas: Foi possível inserir mais uma contribuição com relação ao uso de ferramentas computacionais na literatura sobre o mercado financeiro, como meio de promoção e aprimoramento da eficiência de mercado. Contribuições práticas: Investidores poderão se beneficiar com o uso dos resultados desta pesquisa tanto para se protegerem da seleção adversa e do risco moral e o regulador do mercado de capitais poderá usar técnicas semelhantes para ampliar a fiscalização do mercado, além de ser mais um ponto de partida para a geração de modelos de high-frequency trading.
Steady flow of high-paraffin bituminous binder in cylindrical tube in terms of Herschel – Bulkley fluid
Authors: Matvienko Oleg V. , Litvinova Alyona E. 
Published: August 2021

This paper deals with the flow of bitumen binder in a cylindrical tube described by the Hershel-Bulkley fluid. The dependence is suggested for the fluid flow rate and the pressure drop. Dependences are also determined for the radial velocity distribution and effective viscosity. It is found that at a low pressure drop, the non-Newtonian properties of the medium lead to a significant hydraulic resistance due to the internal structure. With an increase in the pressure drop, the hydraulic resistance of the flow decreases.
Effects of Mineral Fertilizer Doses and Ratios on Tea Yield and Quality
Authors: Hoang Tran Xuan , Thang Vu Ngoc , Thu Dang Van , Binh Nguyen Ngoc , Toan Nguyen Van , Hoang Dinh Thai 
Published: August 2021

Mineral nutrients are essential to plant growth and development. The present study aimed to evaluate the effects of mineral fertilizer doses and N:P:K ratio on growth, yield, and raw material quality of the tea variety PH10 to improve the production of high-quality tea products. The field experiment was conducted from 2015 to 2017. A two-factor experiment was designed by split-plot design with three replications. The mainplot treatments were three fertilizer doses of N for one metric ton of fresh shoot products (30, 40, and 50 kg N ha-1). The subplot treatments were two NPK ratios (3:1:1 and 3:1:2). Plant height, leaf canopy, plant diameter, shoot yield parameters, shoot components, biochemical compounds, and sensory quality for Oolong and Sencha tea products were evaluated. The results showed that increasing fertilizer doses from 30 up to 40 kg N per ton of fresh product improved remarkably growth, yield, and tea quality of PH10 variety. Different fertilizer ratios resulted in variations in plant growth, the content of carbohydrate, sensory quality for taste and flavor as well as total sensory quality with higher values at NPK ratio of 3:1:2. Applying mineral fertilizer with an NPK ratio of 3:1:2 and 40kg N per ton of fresh shoot products was recommended to bring about the most benefits of tea yield and quality as well as economic profit.
Effects of Cover Methods and Nitrogen Levels on the Growth and Yield of Tomato
Authors: Loan Nguyen Thi , Can Tran Thi My 
Published: August 2021

To study the effects of cover methods and nitrogen (N) levels on the growth and yield components of tomato Cv. Pear F1, field experiments with a 4x3 factorial design were conducted in the 2019 spring and winter seasons using a randomized complete block design with three replications. The cover methods included four treatments: bare soil (BS), black plastic mulch (BPM), transparent polypropylene row cover (RC), and a combination of BPM and RC (BPMRC) with the RC removed approximately 30 days after transplanting. Nitrogen (N) was applied at three levels (150, 180, and 210 kg N ha-1). Using BPM and RC generally led to an increased air temperature, air humidity, soil moisture, and soil temperature compared to the BS treatment. Higher N rates (180 and 210 kg N ha-1) did not result in different tomato fruit sizes and fruit weights but positively increased fruit yield and quality (Brix values and fruit dry weight) as compared to the 150 kg N ha-1 addition. The cover methods positively affected the yield components and fruit yield of tomato as well as the fruit characteristics compared to the BS treatment. Using cover materials (BPM and RC) combined with a higher N application significantly increased the yield attributes and fruit yield. The highest fruit yield was achieved under the mulching treatment by black plastic (BPM treatment) combined with a 210 kg N ha-1 application, resulting in 50.90 tons ha-1 in the spring and 58.27 tons ha-1 in the winter.
Riyadh changes priorities - “smart” cities and resorts instead of oil?
Authors: Dudarev Konstantin P. 
Published: August 2021

The article examines the progress of the implementation of socio-economic reforms, which began in 2016 after the promulgation of the new &quot;Strategy of the Kingdom of Saudi Arabia&quot; called &quot;Vision 2030&quot;, and aimed at diversification of the economy and modernization of the country. The focus is on two main areas of economic development - tourism and the construction of &quot;smart&quot; cities of the future.
In accordance with the logic of the new strategy the economic geography of the Kingdom is also changing. If in the previous decades the state&apos;s efforts and investments were directed mainly to the east of the country, on the coast of the Persian/Arabian Gulf, where oil de-posits are concentrated, today, during the transition to the post-oil era, the main attention is paid to unlocking the potential of the western regions adjacent to the coast of the Red Sea.
In brief, the result of 5 years of reforms is that the words &quot;post-oil era&quot; have ceased to be an abstract concept. As an evidence of the population&apos;s support for the reforms, the author cites the results of a survey by UN staff members of the Kingdom&apos;s residents, most of whom expressed satisfaction with the quality of life and the actions of the authorities, as well as the report of the IMF mission, which praised the activities of the KSA government on tourism and the entertainment industry development, to combat the pandemic, and to in-crease the role of the private sector in the country&apos;s economic development.
At the same time, the author believes that despite the obvious successes, it would be a delusion to believe that all the risks associated with the implementation of reforms have been left behind.
PENGEMBANGAN MEDIA PEMBELAJARAN BIG BOOK SIKLUS HIDUP HEWAN UNTUK MENINGKATKAN PEMAHAMAN KONSEP SISWA KELAS IV
Authors: Dewi Elis Sofya , Yanti Yulia Eka 
Published: August 2021

Tujuan penelitian ini yaitu: (1) untuk mengetahui kevalidan media big book siklus hidup hewan, (2) untuk mengetahui kelayakan media big book siklus hidup hewan, (3) untuk mengetahui peningkatan pemahaman konsep siswa. Jenis penelitian yang digunakan adalah R&D ( Research And Development) dengan model ADDIE untuk mengasilkan produk dan menguji kefektifan produk tersebut. Instrumen pengumpulan data yang digunakan adalah lembar validasi ahli materi, angket respon siswa dan soal tes pretest posttest. Hasil penelitian menunjukan bahwa, (1) media big book valid dan dapat digunakan dengan perolehan tingkat kevalidan dari ahli media 81,4%, dari ahli materi 100%, (2) media big book layak digunakan dengan perolehan angket respon siswa 93%, (3) media big book dapat meningkatkan pemahaman konsep siswa dengan hasil uji coba soal pretest postest mengalami peningkatan 27,5%.
Robust Antibody Responses to the BNT162b2 mRNA Vaccine Occur Within a Week After the First Dose in Previously Infected Individuals and After the Second Dose in Uninfected Individuals
Authors: Hirotsu Yosuke , Amemiya Kenji , Sugiura Hiroki , Shinohara Miyuki , Takatori Mika , Mochizuki Hitoshi , Omata Masao 
Published: August 2021

BackgroundVaccines against severe acute respiratory syndrome coronavirus 2 can trigger acquired immunity in infection-naïve individuals and offer a path toward ending the coronavirus disease pandemic that began in 2019. However, the kinetics of early antibody responses in vaccinated individuals remain poorly understood.MethodWe followed BNT162b2 mRNA-vaccinated health care workers (HCWs, N=108) including 103 infection-naïve and five previously infected individuals. A total of 763 blood samples were collected weekly or hourly basis before and after vaccination. Serological analysis of anti-spike and anti-nucleocapsid antibodies was performed.ResultsSeroconversion occurred in all infection-naïve HCWs 3 weeks after the first dose (just before the second vaccination) and a marked boosting effect was observed at 4 weeks (1 week after the second dose). Among previously infected HCWs with pre-existing antibodies against the spike protein, a remarkable boosting effect was observed during the first week after vaccination, and a further increase in antibody titres was observed after the second dose. In one previously infected patient, daily blood sampling was conducted. Antibody titres began to increase 96 hours (4 days) after the first dose.ConclusionThe BNT162b2 mRNA vaccine remarkably enhanced antibody responses after the second dose in infection-naïve individuals and after the first dose in previously infected HCWs of all ages and genders. Antibody titres decreased slightly after the 5th week post-vaccination. The robust boosting effect of immunisation suggests that increased antibody titres following exposure to the virus may restrict viral replication, prolong the incubation period, or lessen the severity of disease.
Predictive Value of Metabolic Parameters Derived From 18F-FDG PET/CT for Microsatellite Instability in Patients With Colorectal Carcinoma
Authors: Liu Hao , Ye Zheng , Yang Ting , Xie Hongjun , Duan Ting , Li Mou , Wu Min , Song Bin 
Published: August 2021

BackgroundMicrosatellite instability (MSI) is one of the important factors that determine the effectiveness of immunotherapy in colorectal cancer (CRC) and serves as a prognostic biomarker for its clinical outcomes.PurposeTo investigate whether the metabolic parameters derived from18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) can predict MSI status in patients with CRC.Materials and MethodsA retrospective analysis was performed on CRC patients who underwent 18F-FDG PET/CT examination before surgery between January 2015 and April 2021. The metabolic 18F-FDG PET/CT parameters of the primary CRC lesion were calculated and recorded with different thresholds, including the maximum, peak, and mean standardized uptake value (SUVmax, SUVpeak, and SUVmean), as well as the metabolic tumor volume (MTV) and the total lesion glycolysis (TLG). The status of MSI was determined by immunohistochemical assessment. The difference of quantitative parameters between MSI and microsatellite stability (MSS) groups was assessed, and the receiver operating characteristic (ROC) analyses with area under ROC curves (AUC) was used to evaluate the predictive performance of metabolic parameters.ResultsA total of 44 patients (24 men and 20 women; mean ± standard deviation age: 71.1 ± 14.2 years) were included. There were 14 patients in the MSI group while there were 30 in the MSS group. MTV30%, MTV40%, MTV50%, and MTV60%, as well as TLG50% and TLG60% showed significant difference between two groups (all p-values &lt;0.05), among which MTV50% demonstrated the highest performance in the prediction of MSI, with an AUC of 0.805 [95% confidence interval (CI): 0.657–0.909], a sensitivity of 92.9% (95% CI: 0.661–0.998), and a specificity of 66.7% (95% CI: 0.472–0.827). Patients’ age and MTV50% were significant predictive indicators of MSI in multivariate logistic regression.ConclusionThe metabolic parameters derived from18F-FDG PET/CT were able to preoperatively predict the MSI status in CRC, with MTV50% demonstrating the highest predictive performance. PET/CT imaging could serve as a noninvasive tool in the guidance of immunotherapy and individualized treatment in CRC patients.
Acupuncture as an Adjunctive Treatment for Post-stroke Epilepsy: Protocol for a Randomized Controlled Trial
Authors: Zhang Yang , Zhao Meidan , Zhang Baozhen , Zhang Kai , Zhou Zhen 
Published: August 2021

Background: Acupuncture has been clinically used to treat epilepsy after stroke. However, most of the current clinical studies are observational studies, and there are few well-designed randomized controlled trials (RCTs). Hence, we designed a multicentre RCT to assess the advantages and efficacy of acupuncture for post-stroke epilepsy (PSE).Methods/Design: This is a two-arm, parallel, participants-blinded and assessor-blinded and multicentre RCT. A total of 120 patients with PSE aged from 18 to 75 years will be randomly assigned to two groups (routine treatment plus acupuncture group and routine treatment plus sham acupuncture group) at a 1:1 ratio. The participants will perform acupuncture or sham acupuncture treatment three times a week and be ongoing 8-week treatment. The primary endpoint is the proportion of seizure-free patients. A safety profile will be established. We will record adverse events for the safety evaluation.Discussion: The study will provide high-quality clinical evidence on the effectiveness and safety of acupuncture for treating patients with epilepsy after stroke.Clinical Trial Registration: Chinese Clinical Trial Registry, identifier: ChiCTR2100046114.
Cortical and Subcortical Anatomy of the Parietal Lobe From the Neurosurgical Perspective
Authors: Dziedzic Tomasz Andrzej , Bala Aleksandra , Marchel Andrzej 
Published: August 2021

Introduction: The anatomical structures of the parietal lobe at the cortical and subcortical levels are related mainly to sensory, visuospatial, visual and language function. The aim of this study was to present an intraoperative perspective of these critical structures in terms of the surgical treatment of intra-axial lesions. The study also discusses the results of the technique and the results of direct brain stimulation under awake conditions.Materials and Methods: Five adult brains were prepared according to the Klingler technique. Cortical assessments and all measurements were performed with the naked eye, while white matter dissection was performed with microscopic magnification.Results: Intra-axial lesions within the parietal lobe can be approached through a lateral or superior trajectory. This decision is based on the location of the lesions in relation to the arcuate fascicle/superior longitudinal fascicle (AF/SLF) complex and ventricular system. Regardless of the approach, the functional borders of the resection are defined by the postcentral gyrus anteriorly and Wernicke's speech area inferiorly. On the subcortical level, active identification of the AF/SLF complex and of the optic radiation within the sagittal stratum should be performed. The intraparietal sulcus (IPS) is a reliable landmark for the AF/SLF complex in ~60% of cases.Conclusion: Knowledge of the cortical and subcortical anatomical and functional borders of the resection is crucial in preoperative planning, prediction of the risk of postoperative deficits, and intraoperative decision making.
Prevention and Treatment of Hardware-Related Infections in Deep Brain Stimulation Surgeries: A Retrospective and Historical Controlled Study
Authors: Li Jiping , Zhang Wenjie , Mei Shanshan , Qiao Liang , Wang Yunpeng , Zhang Xiaohua , Li Jianyu , Hu Yongsheng , Jia Xiaofei , Zhang Yuqing 
Published: August 2021

BackgroundHardware-related infection in deep brain stimulation (DBS) is one of the most commonly reported complications frequently resulting in the removal of implantable pulse generator (IPG).ObjectiveThe aim of this study was to establish a useful strategy to better prevent and treat those infections and to improve the preservation rates of IPG.MethodsWe conducted a retrospective and historical controlled study of all adult patients (≥18 years old) who had undergone initial DBS implantation at a single center. All participants were enrolled in the control group (between June 2005 and June 2014) or intervention group (between July 2014 and May 2019) based on their surgery dates. We used the intraoperative irrigation with hydrogen dioxide solution in the intervention group. Based on the dates of diagnosis, patients with hardware-related infection after DBS were enrolled in group A (between June 2005 and June 2014) or group B (between July 2014 and May 2019). IPG-sparing algorithm (Isa) was applied for group B. The early-onset IPG infections of the control and intervention groups were evaluated. The IPG preservation rates in both groups A and B were statistically analyzed.ResultsSix cases of early IPG infection and subsequent IPG removal occurred in the control group, while none occurred after intraoperative usage of the hydrogen dioxide in the intervention group. IPG preservation rate of infected cases in group B was significantly higher than that in group A (70% vs.16%, p = 0.004).ConclusionThe combined application of hydrogen dioxide solution and Isa seems to be an effective strategy to prevent IPG infection.