bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propuesta de coevaluación de los miembros de las Comisiones Técnicas, una práctica para la mejora continua
Authors: Lagunes Barradas Virginia , Ochoa Rivera Carlos Alberto 
Published: March 2021

El proyecto que aquí se plantea consiste en desarrollar un instrumento que permita a los miembros de las distintas Comisiones Técnicas que se conforman para llevar a cabo las evaluaciones a centros educativos, realizar una coevaluación de su desempeño como parte de dicha comisión, desde su interacción con el personal de CONAIC, su integración con el resto de los pares académicos y su eficiencia en la obtención del reporte final. El fin de estas evaluaciones será el integrar mejores equipos de trabajo y retroalimentar al evaluador sobre su propia participación en el proceso mismo y por qué no, detectar los puntos débiles que pudiera tener el Comité de Acreditación en la selección, comunicación y proceso de gestión de las evaluaciones en general.
The project raised here is to develop an instrument that would allow members of the various technical committees that conform to carry out assessments to schools, conduct a peer assessment of their performance as part of that committee, since its interaction with CONAIC staff , their integration with the rest of the academic peers and efficiency in obtaining the final report. The purpose of these evaluations will integrate the best teams and provide feedback to the assessor about their own participation in the process itself and why not detect weaknesses that could have the Accreditation Committee in the selection, communication and management process evaluations in general.
Identifying coastal saline soil management practices to reduce land degradation and increase crop production in Bangladesh
Authors: Haque Mohammad Asadul 
Published: March 2021

A consecutive three year duration field experiment was carried out to identify which of a suitable mulch material and a planting bed or their combinations potentially reduce salt accumulation in soil and increase snake gourd yield in coastal saline soils. There were nine treatment combinations having three kinds of mulch materials: no mulch (control), rice straw mulch and plastic mulch, and three kinds of planting beds: convex bed, flat bed and concave bed. Plastic mulch reduced electrical conductivity of soil by 32% and increased soil temperature by 23% and gravimetric soil moisture content by 25% over control treatment. Plastic mulch had a fruit yield of 30.73, 28.06 and 26.32 t ha-1, which was 72, 237 and 268 % higher than control treatment in 2018, 2019 and 2020, respectively. The convex bed planting had significantly higher fruit yield than flat bed and concave bed planting. Plastic mulching and convex bed planting may therefore be recommended for reducing soil salinity and improving snake gourd yield in coastal saline regions.
Journal of Bangladesh Academy of Sciences, Vol. 44, No. 2, 145-159, 2020
Estrogen Receptor Positive Secretory Breast Carcinoma in a Bangladeshi Elderly Woman Diagnosed by Core Needle Biopsy
Authors: Abedin Nafisa , Bushrah Kazi Nabila , Md Muktadir Muhit Reza , Dey Bishnu Pada 
Published: March 2021

Secretory carcinoma is an extremely rare subtype of low grade invasive breast carcinoma and occurs infrequently in adults showing belligerent clinical course than in children. Surprisingly, it is the only epithelial carcinoma of breast representing characteristic balanced translocation.This paper reports a case of secretory breast carcinoma in an elderly post-menopausal woman in Bangladesh which is diagnosed by core needle biopsy. The majority of the case reports claimed this tumor to be a triple negative breast carcinoma, whereas our case report reveals a slightly different status in immunohistochemical context. A 78-years old, post-menopausal female presented with the chief complaints of painless, slowly enlarging lump in her left breast over nine months. Breast examination revealed a 2x1.5cm, well-delineated, firm, non-tender and mobile mass in the lower-outer quadrant of the left breast. Microscopically, the tumor was composed of cells containing PAS positive, diastase resistant and mucicarmine positive intra and extra-cellular secretory material and Alcian blue positive secretion was found extracellularly. The tumor cells showed strongly positive immunohistochemical reactivity for cytokeratin, EMA, E-cadherin and vimentin and focal positive reaction for S-100 protein and estrogen receptor but negative for both progesterone receptor and human epidermal growth factor receptor. Ki-67 proliferative index was about 4%. Hence, the diagnosis of secretory breast carcinoma (SBC) was made. The patient underwent modified radical mastectomy with axillary clearance without any axillary lymphnode involvement in an external center. The patient has not received any radio or chemotherapy. The patient was under continuous follow-up for 3-months.Unfortunately, owing to the nation-wide lockdown for dreadful COVID-19 pandemic, the patient couldn’t arrive at the hospital for further follow-up evaluation. Immunohistochemical (IHC) analysis has been proven to be an alternative potential method as gene analysis. Immunoprofiling of secretory breast carcinomas may play the pivotal role for selecting therapeutic strategies and predicting prognostic outcome of the disease process. Comprehending the immunohistochemical expression would make scope for applying targeted therapy in SBC patients in future.
J Dhaka Medical College, Vol. 28, No.2, October, 2019, Page 216-223
A Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatocellular Carcinoma: Single-Center Analyses With Internal Validation
Authors: Yang Jiarui , Zhu Shuguang , Yong Juanjuan , Xia Long , Qian Xiangjun , Yang Jiawei , Hu Xueqiao , Li Yuxuan , Wang Chusi , Peng Wenguang , Zhang Lei , Deng Meihai , Pan Weidong 
Published: March 2021

BackgroundMicrovascular invasion (MVI) is highly associated with poor prognosis in patients with liver cancer. Predicting MVI before surgery is helpful for surgeons to better make surgical plan. In this study, we aim at establishing a nomogram to preoperatively predict the occurrence of microvascular invasion in liver cancer.MethodA total of 405 patients with postoperative pathological reports who underwent curative hepatocellular carcinoma resection in the Third Affiliated Hospital of Sun Yat-sen University from 2013 to 2015 were collected in this study. Among these patients, 290 were randomly assigned to the development group while others were assigned to the validation group. The MVI predictive factors were selected by Lasso regression analysis. Nomogram was established to preoperatively predict the MVI risk in HCC based on these predictive factors. The discrimination, calibration, and effectiveness of nomogram were evaluated by internal validation.ResultsLasso regression analysis revealed that discomfort of right upper abdomen, vascular invasion, lymph node metastases, unclear tumor boundary, tumor necrosis, tumor size, higher alkaline phosphatase were predictive MVI factors in HCC. The nomogram was established with the value of AUROC 0.757 (0.716–0.809) and 0.768 (0.703–0.814) in the development and the validation groups. Well-fitted calibration was in both development and validation groups. Decision curve analysis confirmed that the predictive model provided more benefit than treat all or none patients. The predictive model demonstrated sensitivity of 58.7%, specificity of 80.7% at the cut-off value of 0.312.ConclusionNomogram was established for predicting preoperative risk of MVI in HCC. Better treatment plans can be formulated according to the predicted results.
DNA Methylation of TLR4, VEGFA, and DEFA5 Is Associated With Necrotizing Enterocolitis in Preterm Infants
Authors: Klerk Daphne H. , Plösch Torsten , Verkaik-Schakel Rikst Nynke , Hulscher Jan B. F. , Kooi Elisabeth M. W. , Bos Arend F. 
Published: March 2021

Background: Epigenetic changes, such as DNA methylation, may contribute to an increased susceptibility for developing necrotizing enterocolitis (NEC) in preterm infants. We assessed DNA methylation in five NEC-associated genes, selected from literature: EPO, VEGFA, ENOS, DEFA5, and TLR4 in infants with NEC and controls.Methods: Observational cohort study including 24 preterm infants who developed NEC (≥Bell Stage IIA) and 45 matched controls. DNA was isolated from stool samples and methylation measured using pyrosequencing. We investigated differences in methylation prior to NEC compared with controls. Next, in NEC infants, we investigated methylation patterns long before, a short time before NEC onset, and after NEC.Results: Prior to NEC, only TLR4 CpG 2 methylation was increased in NEC infants (median = 75.4%, IQR = 71.3–83.8%) versus controls (median = 69.0%, IQR = 64.5–77.4%, p = 0.025). In NEC infants, VEGFA CpG 3 methylation was 0.8% long before NEC, increasing to 1.8% a short time before NEC and 2.0% after NEC (p = 0.011; p = 0.021, respectively). A similar pattern was found in DEFA5 CpG 1, which increased from 75.4 to 81.4% and remained 85.3% (p = 0.027; p = 0.019, respectively). These changes were not present for EPO, ENOS, and TLR4.Conclusion: Epigenetic changes of TLR4, VEGFA, and DEFA5 are present in NEC infants and can differ in relation to the time of NEC onset. Differences in DNA methylation of TLR4, VEGFA, and DEFA5 may influence gene expression and increase the risk for developing NEC. This study also demonstrates the use of human DNA extraction from stool samples as a novel non-invasive method for exploring the bowel of preterm infants and which can also be used for necrotizing enterocolitis patients.
What Matters Most to Lung Cancer Patients? A Qualitative Study in Italy and Belgium to Investigate Patient Preferences
Authors: Petrocchi Serena , Janssens Rosanne , Oliveri Serena , Arnou Reinhard , Durosini Ilaria , Guiddi Paolo , Louis Evelyne , Vandevelde Marie , Nackaerts Kristiaan , Smith Meredith Y. , Galli Giulia , de Marinis Filippo , Gianoncelli Letizia , Pravettoni Gabriella , Huys Isabelle 
Published: March 2021

Background: The potential value of patient preference studies has been recognized in clinical individual treatment decision-making between clinicians and patients, as well as in upstream drug decision-making. Drug developers, regulators, reimbursement and Health Technology Assessment (HTA) bodies are exploring how the use of patient preference studies could inform drug development, regulatory benefit risk-assessment and reimbursement decisions respectively. Understanding patient preferences may be especially valuable in decisions regarding Non-Small Cell Lung Cancer (NSCLC) treatment options, where a variety of treatment options with different characteristics raise uncertainty about which features are most important to NSCLC patients. As part of the Innovative Medicines Initiative PREFER project, this qualitative study aimed to identify patient-relevant lung cancer treatment characteristics.Methods: This study consisted of a scoping literature review and four focus group discussions, 2 in Italy and 2 in Belgium, with a total of 24 NSCLC patients (Stages III-IV). The focus group discussions sought to identify which treatment characteristics patients find most relevant. The discussions were analyzed thematically using a thematic inductive analysis.Results: Patients highlighted themes reflecting: 1) positive effects or expected gains from treatment such as greater life expectancy and maintenance of daily functioning, 2) negative effects or adverse events related to therapy that negatively impact patients’ daily functioning such as fatigue and 3) uncertainty regarding the duration and type of treatment effects. These overarching themes were consistent among patients from Belgium and Italy, suggesting that treatment aspects related to efficacy and safety as well as the psychological impact of lung cancer treatment are common areas of concern for patients, regardless of cultural background or country.Discussion: Our findings illustrate the value of using qualitative methods with patients to identify preferred treatment characteristics for advanced lung cancer. These could inform a subsequent quantitative preference survey that assesses patient trade-offs regarding treatment options.
Effectiveness of a Family Support Intervention on Caregiving Burden in Family of Elderly Patients With Cognitive Decline After the COVID-19 Lockdown
Authors: Cravello Luca , Martini Eleonora , Viti Niccolò , Campanello Cristina , Assogna Francesca , Perotta Daniele 
Published: March 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic had a great impact on patients with cognitive decline or dementia. The lockdown period may exacerbate behavioral disorders and worsen distress of caregivers. The aim of this study is to evaluate the effectiveness of a family support intervention on the negative effects that the COVID-19 lockdown may have on patients and related caregivers.Methods: We recruited patients whose related caregivers had attended a family support course before the COVID-19 lockdown. The course was for family members of patients with cognitive decline or dementia and consisted in eight meetings during which the participants received information about the disease, the management of neuropsychiatric symptoms, and community resources and services available for patients with dementia. Data on cognitive decline, neuropsychiatric symptoms, and functional status had been collected before the course with the Mini-Mental State Examination (MMSE), the Neuropsychiatric Inventory (NPI), and the Instrumental (IADL) and Basic (BADL) Activities of Daily Living scales, respectively. The caregiving burden had been evaluated at the end of the course by means of the Zarit Burden Interview (ZBI). After the COVID-19 lockdown, a phone interview was made to compare neuropsychiatric symptoms, functional status, and caregiver's burden with the previous evaluation.Results: There were no significant changes before and after the COVID-19 lockdown in the mean NPI score. The IADL, BADL, and ZBI scores were significantly lower after lockdown than before. The BADL scores were inversely associated with ZBI scores. Thus, despite a worsening of patients' functional status, the caregivers' burden decreased significantly probably due to the positive effect of the family support intervention.Conclusions: Our study demonstrated that a complete family support intervention for caregivers of patients with cognitive decline or dementia can reduce the burden of care even in a particular negative period, such as the COVID-19 lockdown.
Techno-Economic Analysis of Decentralised Small Hydro Power Projects for Rural Electrification: A Case Study of Meenvallom Project in Kerala with the Use of RET Screen Expert Advanced Software
Authors: Samuel Liji 
Published: March 2021

Rural electrification is a fundamental factor of poverty mitigation and rural growth of a nation. In India, electricity has not played an active role in the socio-economic progress of the village. Gross Domestic Product (GDP) is growing by 8%, whereas the involvement of agriculture division is 1.9%. The government of India has encouraged the goal of providing electricity to all villages in various phases. Therefore, the aim of this research was to define the techno-economic analysis of decentralized Small Hydro Power projects in Kerala with the help of RET Screen expert software. The objectives are to explore the potential hydropower to be harvested by Small Hydro Power for rural electrification, to assess financial saving and cost analysis and to investigate the environmental impact of the Small Hydro Power in Kerala. The RET Screen expert is used to assess the economic feasibility of a Small Hydro Power system and to recommend the possibility of installing the technology in the Meenvallom SHP in Kerala. The RET Screen expert is a Clean Energy Management Software developed by the Government of Canada, which is a free-of-charge decision support software for pre-feasibility or feasibility analysis and also ongoing energy efficiency performance analysis (Netscreen Canada). An attempt has been made in this study is to evaluate the features of rural electrification in Kerala and the viability of Small Hydro Power (SHP).
Economic Burden of Malaria: A National Disease
Authors: Sangamithra A , Vishnu S 
Published: March 2021

World Health Organization (WHO) stated that Malaria is a life-threatening parasite illness caused by the Genus Plasmodium spreading to human beings through the bites of infected female Anopheles mosquitoes. Malaria disease is curable and preventable. Unawareness of Malaria in non-endemic areas needs specific attention and the need for health awareness through the health care workers should be enhanced usual care in both areas. Despite being aware of the government programs and measures for the control of Malaria and the endless major problem of health disease in India and many other nations. The complexness and the panic preponderance of the disease are governed by multiple limitations as technological, functional, and monetary and therefore go on inflicting heavy socio-economic losses to people.
A Study on Problems and Prospects of Farmers with Reference to Tirunelveli District
Authors: Sundaramoorthy S , Abirami A 
Published: March 2021

Farmer or agriculture is a person engaged in agriculture, raising living organisms for food or raw materials. They are the vertebrae of our community. All are the ones who present us with all the food that we eat. As a result, the community as a whole of the country depends upon farmers. In addition to the farmers contribute almost 17% of the Indian economy. But the condition of farmers in India is critical. Hence, this study is mainly focused on finding out the problems faced by the farmers why they are shifting area from agriculture to non-agriculture. Both primary and secondary data were used. 350 samples were collected based on a convenient sampling technique. Data were analyzed with the help of SPSS. The significant finding of the study is that Lack of long term policy perspective, Monsoon failure, There is no planning in agricultural land and Importance for traditional cultivation. These four factors mainly induce the farmer shifting area from agriculture to non-agriculture.
MENGUKUR DAMPAK KETERAMPILAN KERJA DAN KOMPENSASI MASA COVID-19 DALAM MENINGKATKAN PRODUKTIVITAS KERJA KARYAWAN
Authors: Febriani Budi , Harahap Aziddin , Simanjuntak Daslan 
Published: March 2021

Covid-19 telah memberikan pelajaran penting bagi perusahaan-perusahaan terkaita hubungannya dengan pengelolaan SDM-nya, banyak perusahaan awalnya kewalahan menghadapi guncangan covid-19 terutama dalam memperhatikan keterampilan kerja dan kompensasi hingga hubungannya terhadap produktivitas kerja. Kemajuan perusahaan bergantung pada produktivitas kerja yang dihasilkan karyawannya melalui keterampilan kerja dan kompensasi yang diterimanya. Hasil penelitian ini membuktikan bahwa keterampilan kerja karyawan dimasa covid-19 masih memiliki hubungan yang kuat dengan produktivitas kerja, sedangkan kompensasi tidak memiliki hubungan yang baik dalam peningkatan produktivitas kerja.
PENGARUH MEDIA PEMBELAJARAN ONLINE DALAM PEMAHAMAN DAN MINAT BELAJAR MAHASISWA PADA BIDANG STUDI AKUTANSI DI FEB UNIVERSITAS LABUHANBATU
Authors: Nasution Siti Lam'ah , Windari Furi , Harahap Syaiful Zuhri , Elvina Elvina 
Published: March 2021

Penerapan dan pelaksanaan pembelajaran jarak jauh (online) disetiap lembaga pendidikan khususnya pada perguruan tinggi merupakan aplikasi dan tidak lanjut dari peraturan yang dikeluarkan pemerintah melalui kementrian pendidikan nasional. Peraturan ini dikeluarkan dalam rangka meminimalisir penyebaran wabah Covie19. Pembelajaran jarak jauh sebenarnya bukanlah hal yang baru dalam dunia pendidikan. Pembelajaran jarak jauh sudah dilaksanakan sebelum adanya wabah Covid19 di Indonesia. Pembelajaran jarak jauh sebelumnya dilaksanakan dengan E-learning yang terintegrasi dengan pembelajaran tatap muka (luring). Akan tetapi pembelajaran jarak jauh saat ini dilakukan secara berkelanjutan sehingga berpotensi memberikan efek atau pengaruh psikologis pada mahasiswa, sehingga pemahaman dan minat belajarnya menjadi menurun. Untuk itu seorang tenaga pendidik (Dosen) harus mampu memilih media yang tepat untuk digunakan dalam pelaksanaan pembelajaran jarak jauh, seorang dosen harus memperteimbangkan metode dan media pembelajaran yang tepat untuk dapat meningkatkan pemahaman mahasiswa pada materi pembelajaran dan mempertahankan motivasi belajarnya. Penelitian ini bertujuan untuk mengeahui pengaruh pembelajaran online dalam pemahaman dan minat belajar mahasiswa pada bidang studi akuntansi. Hasil penelitian menunjukkan bahwa mahasiswa program studi akuntansi Universitas labuhanbatu tidak menyukai atau tidak senang dengan sistem pembelajaran online (daring) yang diterapkan khusunya pada pembelajaran materi akuntansi. Mahasiswa kurang memahami materi pembelajaran akuntansi yang dilakukan secara daring sebab, materi tidak tersampaikan dengan tuntas akibat gangguan jaringan internet yang tidak stabil dan media pembelajaran yang terbatas pada mahasiswa. Minat belajar mahasiswa pada materi akuntansi sangat kuat, akan tetapi dengan metode dan sistem pembelajaran daring membuat tingkat pemahaman mahasiswa pada materi akuntansi masih terbatas.
Glioma C6 perivascular changes of invasion structural parameters variation (research study).
Authors: Kostenikov Nikolay , Dubrovskaya Violetta , Kovanko Elena , Mirolyubova Olga , Mukhina Marina , Ilyushchenko Yury , Stanzhevsky Andrei , Maistrenko Dmitry 
Published: March 2021

A comparative study of the structural characteristics of microvessels with a perivascular arrangement of tumor cells and microvessels with normal structure located in the peritumoral zones of an intracranially implanted glioblastoma ("glioma C6") was conducted. The study was performed on rats. Morphometric method was used to determine the area, internal diameter and length of microvessels for 21 days after the introduction of tumor cells into the brain of rats. Changes in the structure of microvessels with glioblastoma cells were registered throughout the entire observation period. The active role of perivascularly located tumor cells in the transformation of the structure and properties of microvessels involved in the process of glioblastoma invasion into brain tissue is considered.
Key words: glioblastoma, microvessels, morphometry, peritumoral zones.