bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescription Opioid Laws and Opioid Dispensing in US Counties
Authors: Martins Silvia S. , Bruzelius Emilie , Stingone Jeanette A. , Wheeler-Martin Katherine , Akbarnejad Hanane , Mauro Christine M. , Marziali Megan E. , Samples Hillary , Crystal Stephen , Davis Corey S. , Rudolph Kara E. , Keyes Katherine M. , Hasin Deborah S. , Cerdá Magdalena 
Published: July 2021

Background:
Hundreds of laws aimed at reducing inappropriate prescription opioid dispensing have been implemented in the United States, yet heterogeneity in provisions and their simultaneous implementation have complicated evaluation of impacts. We apply a hypothesis-generating, multistage, machine-learning approach to identify salient law provisions and combinations associated with dispensing rates to test in future research.

Methods:
Using 162 prescription opioid law provisions capturing prescription drug monitoring program (PDMP) access, reporting and administration features, pain management clinic provisions, and prescription opioid limits, we used regularization approaches and random forest models to identify laws most predictive of county-level and high-dose dispensing. We stratified analyses by overdose epidemic phases—the prescription opioid phase (2006–2009), heroin phase (2010–2012), and fentanyl phase (2013–2016)—to further explore pattern shifts over time.

Results:
PDMP patient data access provisions most consistently predicted high-dispensing and high-dose dispensing counties. Pain management clinic-related provisions did not generally predict dispensing measures in the prescription opioid phase but became more discriminant of high dispensing and high-dose dispensing counties over time, especially in the fentanyl period. Predictive performance across models was poor, suggesting prescription opioid laws alone do not strongly predict dispensing.

Conclusions:
Our systematic analysis of 162 law provisions identified patient data access and several pain management clinic provisions as predictive of county prescription opioid dispensing patterns. Future research employing other types of study designs is needed to test these provisions’ causal relationships with inappropriate dispensing and to examine potential interactions between PDMP access and pain management clinic provisions. See video abstract at, http://links.lww.com/EDE/B861.
Swabs Containing Tea Tree Oil and Chamomile Oil Versus Baby Shampoo in Patients With Seborrheic Blepharitis: A Double-Blind Randomized Clinical Trial
Authors: Mergen Burak , Arici Ceyhun , Yildiz-Tas Ayse , Bahar-Tokman Hrisi , Tokuc Edip , Ozturk-Bakar Yesim , Kutlubay Zekayi , Sahin Afsun 
Published: July 2021

Purpose:
The comparison of the efficacy of swabs containing tea tree oil and chamomile oil and baby shampoo (BS) in the treatment of seborrheic blepharitis was aimed.

Methods:
This randomized, double-blind, parallel-group, active control, multicenter clinical trial included patients with seborrheic blepharitis using block randomization (BS, n=23; swabs, n=26). Patients were treated with BS or swabs for 8 weeks followed by 4 weeks of treatment withdrawal. Change in Blepharitis Symptom measure (BLISS), Demodex count, Ocular Surface Disease Index (OSDI) score, Schirmer test, tear breakup time (TBUT), noninvasive TBUT (NI-TBUT), corneal staining, and meibography at different visits (baseline, fourth, , and 12th week) were the main outcome measures.

Results:
Patients in both groups showed similar baseline parameters (P>0.05). Patients using swabs showed significantly lower BLISS scores compared with patients using BS at the 4th, 8th, and 12th week visits (3.6±6.1 vs. 6.3±4.5 P=0.011; 1.1±2.8 vs. 6.6±6.7, P<0.001; 0.9±2.8 vs. 5.7±6.6, P=0.002, respectively). Patients using swabs showed improvement in OSDI scores after 8 weeks of treatment compared with the baseline visit (P<0.001). Despite a similar Demodex reduction effect in both treatment arms even after 4 weeks of treatment (P<0.001), both treatment modalities did not show any effect on the other parameters.

Conclusion:
Although both swabs and BS showed efficacy for the treatment of seborrheic blepharitis in terms of the Demodex reduction and symptomatic improvement, swabs may provide better symptomatic improvement. Four weeks of treatment discontinuation may not cause any recurrence in the symptoms or Demodex infestation.
Acquired Syphilis by Nonsexual Contact in Childhood
Authors: Moscatelli Guillermo , Moroni Samanta , García Bournissen Facundo , Falk Nicolás , Destito Alejandra , González Nicolás , Ballering Griselda , D’Amico Indira , García Luciana , Altcheh Jaime 
Published: July 2021

Background:
Children may acquire syphilis by nonsexual contact as a consequence of close and repetitive contact with mucosal or skin lesions of people with active syphilis.

Methods:
Prospective cohort study of pediatric patients with acquired syphilis by nonsexual contact. Demographics, clinical findings, posttreatment serology development and general laboratory data were collected. Sexual transmission was ruled out after a careful medical and psychosocial evaluation of the patient and his/her family.

Results:
Twenty-four patients were included in the study. Mean age at diagnosis was 4.2 years old. All of them came from overcrowded households with poor hygiene conditions. The most frequent reason for consultations was secondary syphilis skin lesions (79.2%). The psychosocial evaluation of children and their families did not reveal signs of sexual abuse in any of the cases. Seventy-eight families and their cohabitants were evaluated, 23 (29.5%) resulted positive for rapid plasma reagin and treponemal test of hemagglutination; 60.9% of the cases were asymptomatic. The symptomatic relatives showed lesions of secondary syphilis. A sustained fall on nontreponemal antibodies titer (rapid plasma reagin) was observed after treatment, becoming negative in 6/24 (25%) cases within 12 months posttreatment.

Discussion:
Following evaluation, it was considered that sexual abuse was unlikely. However, if examination and psychosocial evaluation do not support it, other ways of transmission must be considered. Overcrowded and poor household conditions boost the risks for nonsexual treponema transmission. An infected member of the family or a caretaker are a particular risk to an infant due to common practices such as using saliva to moisten the rubber nipples of the milk bottles or trying the food temperature using the lips before feeding the infants.
Neonatal Coccidioidomycosis
Authors: Vaughn Jessica , Tablizo Mary Anne , Zayed Zahia , Hepple Robert R. , McCarty James M. , Naeem Fouzia 
Published: July 2021

Background:
Coccidioidomycosis is common in adult and pediatric populations living in endemic areas of the United States but has rarely been reported in neonates. We reviewed recent cases of neonatal coccidioidomycosis treated at a tertiary care children’s hospital in an endemic area and compared them with previously reported cases in the literature.

Methods:
We performed a retrospective chart review of infants 1 month old or less hospitalized with a diagnosis of coccidioidomycosis from January 1, 2014, to December 31, 2019. Additionally, we performed a literature review of all reported cases of neonatal coccidioidomycosis over the past 7 decades through PubMed. Infants born to mothers with confirmed or suspected active coccidioidomycosis were excluded.

Results:
Three cases of neonatal coccidioidomycosis were identified at our institution. Each presented in a unique manner and had an alternative diagnosis at the time of initial presentation. Two patients had negative coccidioidal screening tests upon admission but later seroconverted. All patients had extrapulmonary involvement, and all recovered after appropriate treatment. A review of the literature reveals that the presentations and outcomes of neonatal coccidioidomycosis vary widely.

Conclusions:
There is significant variability in the presentation of coccidioidomycosis in the neonatal period, and diagnosis may be challenging. In endemic regions, healthcare providers should consider coccidioidomycosis in their differential diagnoses of ill-appearing neonates that do not respond to treatment.
Domain-Specific Active and Sedentary Behaviors in Relation to Workers’ Presenteeism and Absenteeism
Authors: Koohsari Mohammad Javad , Yasunaga Akitomo , McCormack Gavin R. , Shibata Ai , Ishii Kaori , Nakaya Tomoki , Oka Koichiro 
Published: July 2021

Objectives:
To examine the associations between domain-specific sedentary and active behaviors and workers’ presenteeism and absenteeism in a sample of company employees.

Methods:
This study recruited participants (n = 2466) from a nationwide online survey database (Japan, 2019). Participants completed a questionnaire that captured data on relative and absolute presenteeism and absenteeism and domain-specific physical activity and sedentary behaviors.

Results:
Daily minutes of work-related physical activity were negatively associated with relative absenteeism. Daily minutes of leisure-related physical activity were positively associated with absolute presenteeism (ie, better productivity). Daily minutes of total physical activity were negatively and positively associated with relative absenteeism and absolute presenteeism (ie, better productivity). There was also a positive association between car sitting time and absolute absenteeism.

Conclusions:
A change in work culture and practices that support active behaviors at work and outside of work may improve employee's productivity indices.
Mini-Trampoline Jumping as an Exercise Intervention for Postmenopausal Women Who Experienced a Stroke: A Case Report
Authors: Fricke Anja , Fink Philip W. , Lark Sally D. , Mundel Toby , Shultz Sarah P. 
Published: July 2021

Introduction:
This case report details a mini-trampoline exercise intervention for a 56-year-old postmenopausal woman who experienced a stroke 7 years ago, which has not previously been reported in medical literature.

Case Description:
The patient was diagnosed with a cerebral infarction on the left hemisphere following 3 aneurysms at 49 years of age. The patient underwent extensive physical rehabilitation for 6 years, which included physiotherapy, swimming, walking, and attending a cardiac exercise clinic. Although she is able to walk unaided, she still experiences a right-sided hemiparetic gait.

Outcomes:
The patient showed great improvements in walking speed, lower leg strength, flexibility, pelvic floor muscle strength, bone health, and some aspects of balance following a supervised 12-week mini-trampoline exercise intervention and 12-week follow up.

Discussion:
This article represents a case in which a mini-trampoline exercise intervention improved physical function and female-specific health risk factors in a postmenopausal woman who experienced a stroke 7 years ago.
Hospital Length of Stay Prediction Methods
Authors: Lequertier Vincent , Wang Tao , Fondrevelle Julien , Augusto Vincent , Duclos Antoine 
Published: July 2021

Objective:
This systematic review sought to establish a picture of length of stay (LOS) prediction methods based on available hospital data and study protocols designed to measure their performance.

Materials and Methods:
An English literature search was done relative to hospital LOS prediction from 1972 to September 2019 according to the PRISMA guidelines. Articles were retrieved from PubMed, ScienceDirect, and arXiv databases. Information were extracted from the included papers according to a standardized assessment of population setting and study sample, data sources and input variables, LOS prediction methods, validation study design, and performance evaluation metrics.

Results:
Among 74 selected articles, 98.6% (73/74) used patients’ data to predict LOS; 27.0% (20/74) used temporal data; and 21.6% (16/74) used the data about hospitals. Overall, regressions were the most popular prediction methods (64.9%, 48/74), followed by machine learning (20.3%, 15/74) and deep learning (17.6%, 13/74). Regarding validation design, 35.1% (26/74) did not use a test set, whereas 47.3% (35/74) used a separate test set, and 17.6% (13/74) used cross-validation. The most used performance metrics were R
2 (47.3%, 35/74), mean squared (or absolute) error (24.4%, 18/74), and the accuracy (14.9%, 11/74). Over the last decade, machine learning and deep learning methods became more popular (P=0.016), and test sets and cross-validation got more and more used (P=0.014).

Conclusions:
Methods to predict LOS are more and more elaborate and the assessment of their validity is increasingly rigorous. Reducing heterogeneity in how these methods are used and reported is key to transparency on their performance.
Changes in Depression and Sleep Quality and Associated Factors in Women Receiving Chemotherapy for Ovarian Cancer
Authors: Wu Hui-Ju , Chuang Chi-Mu , Chien Ching-Hui , Wang Tsae-Jyy , Liang Shu-Yuan 
Published: July 2021

BackgroundAlthough women with ovarian cancer experience depression and poor sleep quality, little is known about how various factors, particularly self-efficacy, might be associated with these conditions.ObjectivesThe aim of this study was to examine the prevalence of and changes in depression and sleep quality and the factors associated with these conditions in a cohort of women with ovarian cancer before, during, and after chemotherapy.MethodsA prospective repeated-measures design was adopted in this study. Participants were women with ovarian cancer who were expected to receive 4 to 6 cycles of chemotherapy and were recruited at a medical center in Taiwan. The participants were asked to complete a questionnaire that included the Symptom Distress Scale, Center for Epidemiologic Studies Depression Scale, General Self-efficacy Scale, and Pittsburgh Sleep Quality Index. The data were collected before, during, and after the course of chemotherapy.ResultsOverall, 24.6% to 36.9% of women were at risk for depression; 75.4% to 80.0% of women had poor sleep quality. There were no significant changes in depressive symptoms and sleep quality throughout the course of chemotherapy. More severe depressive symptoms were associated with higher levels of symptom distress and lower self-efficacy. Poorer sleep quality was associated with higher levels of symptom distress.ConclusionsAmong participants, more depressive symptoms and poorer sleep quality were associated with higher levels of symptom distress or lower self-efficacy.Implications for PracticeHealthcare providers should continuously assess depression and sleep quality in women with ovarian cancer. These symptoms may be improved by strengthening self-efficacy and relieving symptom distress.
A Qualitative Study of Cancer Survivors’ Experienced Outcomes of a Multidimensional Rehabilitation Program in Primary Healthcare
Authors: Løken Oddbjørg Utheim , Hauken May Aasebø 
Published: July 2021

BackgroundCancer survival rates are increasing, but survival is often followed by several late effects. Cancer survivors’ need for complex rehabilitation is well documented, but this is mostly missing in primary healthcare.ObjectiveThe aim of this study was to explore cancer survivors’ experienced outcomes of a multidimensional rehabilitation program in primary healthcare.MethodsThe study used a qualitative method with a descriptive research design. Fifty-six cancer survivors completed a 12-week rehabilitation program built upon the 5 elements of goal setting, physical exercise, psychoeducation, individual follow-up, and peer support. Data were collected at the end of the program via 8 focus group interviews, and systematic text condensation was used to analyze the data.Results“Increased coping and participation” was identified as the overarching theme of the participants’ experienced outcomes from the program, and this was elaborated by 3 main themes: (1) “increased energy and capacity,” (2) “acceptance and understanding,” and (3) “structure and hope.”ConclusionThe multidimensional rehabilitation program seemed to address cancer survivors’ multiple challenges in survivorship. Proximity and accessibility to a local rehabilitation program and professionals’ competence seemed to be essential factors for the participants’ experienced outcomes of the program.Implication for PracticeA multidimensional rehabilitation program integrated in a Healthy Life Centre in primary healthcare may be beneficial for cancer survivors’ coping and participation in everyday life. Cancer nurses play a crucial role in initiating and facilitating such programs.
Quality of Oncology Nursing Care as Perceived by Patients With Cancer
Authors: Abu Sharour Loai , Al Sabei Sulaiman , Al Harrasi Maryam , Anwar Samah , Bani Salameh Ayman , Al Qadire Mohammad 
Published: July 2021

Background
Patient satisfaction was defined as expectation and perception of the patients about real nursing care they receive.

Objective
The aim of this study was to evaluate the quality of oncology nursing care as perceived by patients with cancer in 3 Arabic countries (Jordan, Oman, and Egypt).

Methods
A cross-sectional design with convenience sampling approach was used. A total of 517 patients with cancer (Jordan, 200, 38.7%; Sultanate of Oman, 137, 26.5%; and Egypt, 180, 34.8%) participated and completed the study’s questionnaires including sociodemographic data and the Quality of Oncology Nursing Care Scale (QONCS).

Results
Moderate quality of oncology nursing care was reported by the participants. The overall mean for the quality of oncology care as measured by the QONCS-Ar (QONCS Arabic version) was highest in Oman (153.40; SD, 4.10), followed by Jordan (150.93; SD, 2.10) and then Egypt (148.0; SD, 3.80). The results were significantly different in the total score of the QONCS-Ar (F = 45.20, P < .001) among the 3 countries. The results also differed in all domains of oncology nursing care according to days of treatment and marital status.

Conclusion
Findings are considered a baseline for future research and highlight the importance of evaluating quality of oncology nursing care as perceived by the patients with cancer.

Implications for Practice
The results from the current study can be used to develop an interventional program focusing on the needs of patients and their perceptions of care.
A Novel Septoplasty Technique for Patients With Nasal Fractures
Authors: Chen Feifei , Yan Yongyi , Gong Huicheng 
Published: July 2021

Abstract
Nasal structures have both functional and cosmetic significance. These structures maintain the shape of the nose and regulate the nasal airflow. During trauma, fractures of the nasal bone are frequently associated with nasal septum deviations. This can lead to the nasal bone collapsing and nasal obstruction. The septoplasty technique is a major surgical intervention to improve nasal obstructions, with the submucosal resection of the deviated septum. In the past, septoplasty was deferred until the nasal bone fracture was healed to reduce the postoperative risk of saddle-nose and flat nose deformities. Advances in technology have enabled surgeons to attempt septoplasty together with a closed reduction of the nasal bone fraction. It is most important to preserve the septal support structure during surgery. Hence, we advocate that the nasal septum be reset in the midline rather than removed, by modified endoscopic septoplasty.
Latissimus Dorsi Muscle Flap for Scalp Reconstruction and Postoperative Ulceration Management
Authors: Deng Ke , Xiao Haitao , Wang Huaisheng , Xu Xuewen 
Published: July 2021

AbstractThe latissimus dorsi muscle (LDM) flap has been widely accepted as the best choice for subtotal or total scalp reconstruction. Because of the unique anatomic and functional features of scalp, ulcerations formation would occur after reconstructive surgeries. in this study, we are presenting a patient with a large scalp defect successfully reconstructed by a latissimus dorsi muscle free flap. Ulcerations with skull exposure formed on the transplanted flap after the first surgery. They were subsequently repaired by flap recycling and tissue expansion techniques. An excellent reconstructive outcome was achieved at the 30-month follow-up after the last surgery and no further complication was found. This clinical report highlights the possibility of ulcer formation after scalp reconstructive surgeries and supports the use of recycle flaps and tissue expanders to manage postoperative ulcerations after latissimus dorsi muscle free flap transplantation.
The Regulation of Neutrophil Extracellular Trap–induced Tissue Damage by Human CD177
Authors: Yoneyama Tomohisa , Maeda Akira , Kogata Shuhei , Toyama Chiyoshi , Lo Pei-Chi , Masahata Kazunori , Kamiyama Masafumi , Haneda Tomoko , Okamatu Chizu , Eguchi Hiroshi , Tazuke Yuko , Ueno Takehisa , Okuyama Hiroomi , Miyagawa Shuji 
Published: July 2021

Background.
Neutrophil-induced tissue damage contributes to the rejection in xenotransplantation. Therefore, suppressing neutrophil function could be effective in suppressing xenogeneic rejection. In a previous study, we demonstrated that the ectopic expression of human cluster of differentiation 31 (CD31) on porcine endothelial cells (PEC) significantly suppressed neutrophil-mediated cytotoxicity through the homophilic binding of CD31. Cluster of differentiation 177 (CD177) was recently reported to be a high-affinity heterophilic binding partner for CD31 on endothelial cells. Thus, we hypothesized that human CD177 on PEC might induce a stronger suppression in neutrophil-mediated cytotoxicity compared with CD31. In this study, the inhibitory function of human CD177 on PEC in neutrophil-mediated cytotoxicity was investigated.

Methods.
PEC were transfected with a cloning plasmid containing cDNA inserts that encoded for hCD177 and hCD31 genes. Neutrophil-induced cytotoxicity was evaluated by flow cytometry after coculturing with PEC or PEC/CD177 in the presence of phorbol 12-myristate 13-acetate. To elucidate the mechanisms responsible for hCD177-induced suppression, the phosphorylation of src homology region 2 domain containing phosphatase 1 was measured by immunoblot analysis.

Results.
Human CD177 on PEC induced a significant reduction in neutrophil-induced cytotoxicity. In addition, CD177 on PEC induced a significant increase in the phosphorylation of src homology region 2 domain-containing phosphatase 1 in neutrophils and suppressed NETosis.

Conclusions.
These findings suggest that human CD177 suppresses neutrophil-mediated cytotoxicity through the inhibition of NETosis.