bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legal Regulation of Invasive Alien Species with Regards to Climate Change in Ukraine
Authors: Kopytsia Yevheniia Mykolaivna , Туліна Ельбіс Євгенівна 
Published: December 2021

The present paper is devoted to the problems of legal regulation of protecting biological diversity from the harmful effects of invasive alien species (hereinafter, IAS) with regards to climate change. Taking into consideration the fact that one of the main principles of environmental protection is the preservation of spatial and species diversity, legal understanding of the interconnectedness between climate change and harmful biological influences, is of great scientific and practical significance.
Notably, the protection of the environment from the adverse effects of IAS and climate change is interconnected with the conservation and sustainable use of biological resources, as stated by the provisions of the Convention on Biological Diversity (Rio de Janeiro, 1992) and its protocols and decisions. Thus, one should acknowledge that climate change and invasive alien species are not only two of the key threats to biodiversity, but are directly interrelated and can act synergistically, presenting additional pressure for conservation and sustainability.
Meanwhile, current legal regulation of both, climate change and IAS is relatively new to Ukrainian legislation, mostly done by means of international legal instruments. The existing national legal acts are generally of a strategic nature and address these issues separately with few legal provisions mentioning their interconnection.
The paper substantiates the need to acknowledge and legally define the interrelation between climate change and invasive alien species. Thus, the development of appropriate regulatory framework for prevention and control of IAS should be carried out with consideration of climate change issues. In turn, national environmental legislation, in particular national framework law ‘On Environmental Protection’ as well climate change policy and laws should be complemented by provisions incorporating IAS management as a tool for reducing pressure on ecological services and enhancing ecosystem resilience.
Role of MicroRNAs and Long Non-Coding RNAs in Regulating
Angiogenesis in Human Breast Cancer: A Molecular Medicine
Perspective
Authors: Golhani Vandana , Ray Suman Kumar , Mukherjee Sukhes 
Published: December 2021

:
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are proficient in
regulating gene expression post-transcriptionally. Considering the recent trend in
exploiting non-coding RNAs (ncRNAs) as cancer therapeutics, the potential use of
miRNAs and lncRNAs as biomarkers and novel therapeutic agents against angiogenesis
is an important scientific aspect. An estimated 70% of the genome is actively
transcribed, only 2% of which codes for known protein-coding genes. Long noncoding
RNAs (lncRNAs) are a large and diverse class of RNAs > 200 nucleotides in length, and
not translated into protein, and are of utmost importance and it governs the expression
of genes in a temporal, spatial, and cell context-dependent manner. Angiogenesis is an
essential process for organ morphogenesis and growth during development, and it is
relevant during the repair of wounded tissue in adults. It is coordinated by an equilibrium
of pro-and anti-angiogenic factors; nevertheless, when affected, it promotes several
diseases, including breast cancer. Signaling pathways involved here are tightly
controlled systems that regulate the appropriate timing of gene expression required for
the differentiation of cells down a particular lineage essential for proper tissue
development. Lately, scientific reports are indicating that ncRNAs, such as miRNAs, and
lncRNAs, play critical roles in angiogénesis-related to breast cancer. The specific roles
of various miRNAs and lncRNAs in regulating angiogenesis in breast cancer, with
particular focus on the downstream targets and signaling pathways regulated by these
ncRNAs with molecular medicine perspective, are highlighted in this write-up.
Circulating miR-126 as a Potential Non-invasive Biomarker for Intracranial Aneurysmal Rupture: A Pilot Study
Authors: Wu Jianing , Gareev Ilgiz , Beylerli Ozal , Mukhamedzyanov Albert , Pavlov Valentin , Khasanov Dinar , Khasanova Guzel 
Published: December 2021

Aim:
Intracranial aneurysms (IAs) are characterized by abnormal dilation and thinning
of the cerebral vessels wall, leading to rupture and life-threatening aneurysmal subarachnoid hemorrhage
(aSAH) condition. This dictates the need to find new biomarkers that predict the presence of
IAs and the risk of their rupture. The aim of this study was to measure circulating miR-126 at various
time points post-aSAH to identify the timing of peak levels.

Methods:
Plasma samples from 62 patients with unruptured IAs (UIAs), 80 patients with aSAH at
various time points (1, 3, 7, and 14 days post-event), and 47 healthy control were collected and subjected
to qRT-PCR analyses for the expression levels of circulating miR-126. ROC curve and AUC
were used to evaluate the diagnostic value of circulating miR-126.

Results:
The expression levels of circulating miR-126 were increased in patients with UIAs than in
the healthy control. Furthermore, the expression levels of circulating miR-126 rose substantially
from day 1 to day 7, but with a moderate decrease from day 7 to day 14 in plasma of patients with
aSAH. The peak was observed on day 7. The AUC for miR-126 was 0.75, 0.75, 0.82, 0.87, and
0.79, respectively, and demonstrated that circulating miR-126 displayed considerable accuracy in
discriminating plasma of patients with UIAs and patients after aSAH at various time points from a
healthy control.

Conclusion:
Our results indicated that circulating miR-126 in plasma samples could be served as a
potential non-invasive biomarker in IAs detection and prevention IAs with a high risk of rupture.
Current MRI Methods for the Assessment of Pathologic Prostate: A Brief
Review for Clinicians
Authors: Salazar-Ruiz Shirley-Yoselin , Chilaca-Rosas Maria-Fatima , Sanchez-Rodriguez Irma-Gabriela , Corona-Cedillo Roberto , Ternovoy Sergey K. , Roldan-Valadez Ernesto 
Published: December 2021

:
The application of magnetic resonance imaging (MRI) have helped in different modalities
for prostate cancer management, from early detection to treatment planning and follow-up, the
evolution of MRI techniques allows to obtain not only anatomical but also functional information
to take advantage of prostate cancer detection and staging while supplying prognostic and predictive
biomarkers. This review presents conventional and advanced MRI techniques (known as multiparametric
MRI) that allow functional and quantitative assessment of the normal prostate gland
and its correlation with prostate cancer. Additional topics include the epidemiology of prostate cancer
following the Global Burden Diseases Cancer Collaboration 2018, the clinical anatomy of the
prostate gland, and the lower urinary tract; we also mention some aspects of the diagnosis performance
in ultrasound. We end the review with a brief explanation about the anatomical foundation
of external-beam planning radiotherapy.
Essential Oils of Basil Cultivars Selectively Affect the Activity of Antioxidant
Enzymes in Murine Glial Cells
Authors: Sahakyan Naira , Andreoletti Pierre , Petrosyan Margarit , Cherkaoui-Malki Mustapha 
Published: December 2021

Aims:
This work aimed to reveal some mechanisms of influence of three basil EO on
the microglial cells, as recently, research data stated that these oils have anti-aging and neuroprotective
properties, and they are found to be effective against some forms of neurodegeneration.

Background:
The microglial cells play a pivotal role as the neuroprotective agents against neuroinflammation.
Ocimum subspecies are a rich source of essential oils (EO) and used to be applied
since antiquity for different purposes, including the prevention and treatment of various diseases.

Objective:
In this study, the influence of the essential oils extracted from three basil cultivars (O.
basilicum var. purpureum, O. basilicum var. thyrsiflora, and O. x citriodorum), possessing remarkable
antioxidant activity, on the activity of the main antioxidant enzymes in microglial BV-2 wild
type (WT) and Acetyl-CoA oxidase deficient cell lines (Acox1-/-) was evaluated.

Method:
All manipulations were carried out using murine microglial BV-2 cell lines (BV-2,
Acyl- CoA oxidase type 1 (ACOX1) deficient mutants (Acox1-/-), and WT cells).

Result:
Data included in the present article state that plant origin substances can play a role in the
regulation of enzymatic antioxidant activity of cells. EOs extracted from the Ocimum different cultivars
are able to trigger the activity of acetyl-CoA oxidase type 1 (or palmitoyl-CoA oxidase type
1), which can serve as a basis for the regulation of redox deviation in WT cells.

Conclusion:
Thus, it can be suggested to apply them for the prevention of some processes, which
can influence aging, as the process of ageing is commonly associated with mitochondrial dysfunction,
oxidative stress caused by the increased level of free radical production, dysfunction of the microglia,
high blood pressure, and so on.

Practical Applications:
The microglial cells play a pivotal role as the neuroprotective agents
against neuroinflammation. Different data included in the present article described that plant origin
substances can play a role in regulating the enzymatic antioxidant activity of cells. EOs extracted
from different cultivars of Ocimum are able to trigger the activity of acetyl-CoA oxidase type 1
(palmitoyl-CoA oxidase type 1), which can serve as a basis for the regulation of redox deviation in
WT cells. Therefore, it can be proposed to apply them as prevention of some processes, which can
influence aging, since the process of aging is commonly associated with mitochondrial dysfunction,
oxidative stress caused by the increased level of free radical production, dysfunction of the microglia,
high blood pressure and so on.
Language of Uzbek national dance art movements
Authors: Sayfullaeva Ra'no , Hamroeva Hulkar , Butunbaeva Tomaris Azam 
Published: December 2021

This article examines the national-cultural lines of Uzbek dance, the language of subject dances, and their movements. Therefore, along with many other intangible cultural heritage values, it is necessary to pass on to future generations the rich experience accumulated in the art of Uzbek national dance. "Preservation of the art of dance, which embodies national values, customs, and traditions, as an ancient source of our spirituality and culture, the restoration of its disappearing forms and movements, terms, the nature of dance, its structure, performance features, objects, clothing, and jewelry. The scientific study of the role of performance in complement, refinement, and bleaching is one of the urgent tasks facing the executive choreographer, organizer, and researchers working in the field of dance. To this end, one of the important issues facing the scientific community is to improve the textual and video recording system of dance performances, as well as the creation of special terminology.
Web-Based Discussion and Illicit Street Sales of Tapentadol and Oxycodone in Australia: Epidemiological Surveillance Study
Authors: Black Joshua , Margolin Zachary R , Bau Gabrielle , Olson Richard , Iwanicki Janetta L , Dart Richard C 
Published: December 2021

Background
Opioid use disorder and its consequences are a persistent public health concern for Australians. Web activity has been used to understand the perception of drug safety and diversion of drugs in contexts outside of Australia. The anonymity of the internet offers several advantages for surveilling and inquiring about specific covert behaviors, such as diversion or discussion of sensitive subjects where traditional surveillance approaches might be limited.

Objective
This study aims to characterize the content of web posts and compare reports of illicit sales of tapentadol and oxycodone from sources originating in Australia. First, post content is evaluated to determine whether internet discussion encourages or discourages proper therapeutic use of the drugs. Second, we hypothesize that tapentadol would have lower street price and fewer illicit sales than oxycodone.

Methods
Web posts originating in Australia between 2017 and 2019 were collected using the Researched Abuse, Diversion, and Addiction-Related Surveillance System Web Monitoring Program. Using a manual coding process, unstructured post content from social media, blogs, and forums was categorized into topics of discussion related to the harms and behaviors that could lead to harm. Illicit sales data in a structured format were collected through a crowdsourcing website between 2016 and 2019 using the Researched Abuse, Diversion, and Addiction-Related Surveillance System StreetRx Program. In total, 2 multivariable regression models assessed the differences in illicit price and number of sales.

Results
A total of 4.7% (28/600) of tapentadol posts discussed an adverse event, whereas 10.27% (95% CI 9.32-11.21) of oxycodone posts discussed this topic. A total of 10% (60/600) of tapentadol posts discussed unsafe use or side effects, whereas 20.17% (95% CI 18.92-21.41) of oxycodone posts discussed unsafe use or side effects. There were 31 illicit sales reports for tapentadol (geometric mean price per milligram: Aus $0.12 [US $0.09]) and 756 illicit sales reports for oxycodone (Aus $1.28 [US $0.91]). Models detected no differences in the street price or number of sales between the drugs when covariates were included, although the potency of the pill significantly predicted the street price (P<.001) and availability predicted the number of sales (P=.03).

Conclusions
Australians searching the web for opinions could judge tapentadol as safer than oxycodone because of the web post content. The illicit sales market for tapentadol was smaller than that of oxycodone, and drug potency and licit availability are likely important factors influencing the illicit market.
The Effectiveness of a Nonguided Mindfulness App on Perceived Stress in a Nonclinical Dutch Population: Randomized Controlled Trial
Authors: Kranenburg Leonieke W , Gillis Jamie , Mayer Birgit , Hoogendijk Witte J G 
Published: December 2021

Background
Mindfulness has become increasingly popular, and positive outcomes have been reported for mindfulness-based interventions (MBIs) in reducing stress. These findings make room for innovative perspectives on how MBIs could be applied, for instance through mobile health (mHealth).

Objective
The aim of this study is to investigate whether a nonguided mindfulness mobile app can decrease perceived stress in a nonclinical Dutch population over the course of 8 weeks, with follow-up at 6 months.

Methods
A randomized controlled trial was performed to compare an experimental group that made use of a structured 8-week mHealth mindfulness program and a control group after 8 weeks, with follow-up after 6 months. Participants were recruited via a national television program. The primary outcome measure was perceived stress as measured by the Perceived Stress Scale, secondary outcomes were symptoms of burnout (measured using the visual analog scale [VAS]) and psychological symptoms (measured using the Four-Dimensional Symptom Questionnaire [4DSQ] at follow-up). Outcomes were analyzed using a multilevel regression model.

Results
At baseline, 587 respondents were included. Results showed no postintervention differences between groups for the level of perceived stress. With regard to the secondary outcome measures, the VAS for emotional exhaustion and physical exhaustion showed significantly lower scores for the experimental group after 8 weeks (P=.04 and P=.01, respectively), but not at follow-up. There were no differences between groups for psychological symptoms measured using the 4DSQ.

Conclusions
These findings do not support our hypothesis that using the mindfulness app would reduce stress levels. However, our findings related to diminished exhaustion at 8 weeks are encouraging and require further investigation.

Trial Registration
ClinicalTrials.gov NCT05246800; https://clinicaltrials.gov/show/NCT05246800
Prevention of COVID-19 Through Optimization of Tabi’at: A Unani Medicine’s Perspective
Authors: Saleem Sahar , Saleem Sony , Jabeen Farkhunda , Shamim Shazia S. , Bano Uzma 
Published: December 2021

Background: Unani System of Medicine (USM) is one of the traditional systems of medicine practiced in India and the Indian subcontinent. It is a holistic system of health care based on inceptive principles applied by Hippocrates, Galen, and Ibn-e-Sina, the founders of present-day medicine. USM encompasses a distinct way of looking at the human body and it considers health to be the result of natural dynamic harmonious balance within the body. USM also recognizes the presence of inherent wisdom which is responsible for controlling all physiological functions, maintenance of health, restoration of health, and self-healing. This intrinsic ability of the body to restore health and the mechanism that activates the body’s healing process is called Tabi’at/ physis. The ultimate goal of prevention of disease can be obtained by optimization of tabi’at/physis, increasing the host defense. It can be achieved through the implication of asbab-e-sitta zarooriyah which includes some Unani Regimenal Therapies also, fostering change in lifestyle habits resulting in good health.
Aims: In this raging pandemic all the therapeutic strategies are based on destroying the agent, breaking the means of transmission and immunization. Although we are leaving behind a huge gap in maintaining the host defense even though it has a crucial role in disease dynamics. In this paper, we have attempted to highlight the concept of tabi’at/Physis and its optimization to prevent this disease and its transmission.
Methods: The authors had gone through classical Unani medical textbooks books related to the concept of tabi’at, asbab-e-sitta zarooriyah, and various modalities that help in health promotion and host defense. Important Unani medicine textbooks like Al Qanoon, Kamilus Sana’at, Kitab-al- Hawi, Al-asbab wa Alamat, Moalijat Buqratiya, Firdausul Hikmat and Kitabul Mansuri in addition to other published literature on the concerned subject was also reviewed for further clarification on the topic.
Keywords: Unani System of Medicine, Tabi’at (physis), Host defense & Asbab-e- Sitta zarooriyah
Assessment of Depression, Anxiety and Stress among Healthcare Students during COVID-19 Pandemic: A Cross Sectional Study
Authors: Mahendra Kumar R , Reenal Naik R , Kukarni Rahul , Nyamagoud Sanatkumar 
Published: December 2021

Background: A Corona virus pandemic now has had a huge impact on quality of life all around the world. People's mental health has been affected by quarantine. The economic delays could have long term impacts on the psychology of students as they are more likely to be graduated later than they have expected. The number of factors contributed to gravitate the psychological disturbances including online education, financial worries and academic pressure.
Aims and Objectives: This Study was to determine the level of Depression, Anxiety and Stress among Students during COVID-19 Pandemic. Furthermore, to see if there's a correlation between demographic profile and the DASS-21.
Materials and methods: A cross-sectional survey was conducted among the healthcare students using DASS-21 which included a conventional DASS questionnaire along with demographic characteristics. A Google form link was shared through social media-WhatsApp and E-mail and data was collected and analyzed using excel sheet to examine the levels of depression, anxiety, and stress among students.
Results: The study enrolled a total of 303 students. The prevalence of moderate depression, anxiety, and stress was found to be 37.9%, 337.9%, 34.9% and 33%, respectively. Males were represented up to 54.13 percent of the population, while females accounted for 45.87 percent. Female responders were more likely than their male counterparts to experience depression and anxiety, whereas stress levels were found to be comparable in both genders.
Conclusion: The average scores of depression, anxiety, and stress in this study were significantly high. Depression, anxiety, and stress are now all associated with a variety of causes. Students develop depression and anxiety as a result of a lack of academic and social life. Students may be stressed due to a lack of exercise and economic difficulties.
Keywords: Depression, DASS-21, Mental Health, Pandemic, Students, Social Life
Formulation and Evaluation of Cefaclor Extended-Release Tablet
Authors: Likhariya Manoj , Trivedi Dipali , Bhadoria Juhi , Modi Amit 
Published: December 2021

Over past 30 years as the expanse and complication involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of extended or controlled release drug delivery systems.
In the present research work an attempt has been made to optimize, formulate and characterize extended-release tablet of Cefaclor. The preformulation studies were performed for the drug (e.g., physico-chemical properties, melting point, solubility etc.). The drug had shown the results under standard specifications. UV spectroscopic analytical method was also performed for quantitative determinations by plotting standard curve. Before this the pure drug was also scanned for the ƛ max value at different concentrations.
The pre-compressions parameters and the post compression parameters for the nine formulated tablets were performed. The drug release study of the selected formulations EF3, EF6 and EF9 was performed as those formulations has shown the results within pharmacopoeia limits. The Formulation EF9 was then taken for release kinetic study as it has shown best results among the other three formulations. So, it confirms the drug release by Higuchi diffusion mechanism. From the results, conclusion can be drawn that the formulation consisting 10-12% concentration of hydroxypropyl methyl cellulose K4-M with 1% microcrystalline cellulose and 25% of lactose are considered as ideal for the optimized extended-release tablet formulation for Cefaclor.
Keywords: Extended release, Cefaclor, Higuchi diffusion mechanism, PBP, bacterial cell wall synthesis.