bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Prevention and Treatment Control on SVEIR Type Model Spread of COVID-19
Authors: Nainggolan Jonner 
Published: November 2021

COVID-19 pandemic has disrupted the world's health and economy and has resulted in many deaths since the first case occurred in China at the end of 2019. Moreover, The COVID-19 disease spread throughout the world, including Indonesia on March 2, 2020. Coronavirus quickly spreads through droplets of phlegm through the throat to the lungs. Researchers in the medical field and the exact science are jointly examined the spread, prevention, and optimal control of COVID-19 disease. Due to the prevention of COVID-19, a vaccine has been found in early 2021, which at the time, the vaccination process was carried out worldwide against COVID-19. This paper examines the spread model of SVEIR-type COVID-19 by considering the vaccination subpopulation. In this study, control of prevention efforts ( and ) and healing efforts are given and being analyzed with the fourth-order Runge-Kutta approach. Based on numerical simulations, it can be seen that using the controls and can reduce the number of infected individuals in the subpopulation compared to those without control. The control can increase the number of recovered individual subpopulations.Keywords: COVID-19; SVEIR model; optimal control; treatment; vaccination.
On Rainbow Vertex Antimagic Coloring of Graphs: A New Notion
Authors: Marsidi Marsidi , Agustin Ika Hesti , Dafik Dafik , Kurniawati Elsa Yuli 
Published: November 2021

All graph in this paper are simple, finite, and connected. Let be a labeling of a graph . The function is called antimagic rainbow edge labeling if for any two vertices and , all internal vertices in path have different weight, where the weight of vertex is the sum of its incident edges label. The vertex weight denoted by for every . If G has a antimagic rainbow edge labeling, then is a antimagic rainbow vertex connection, where the every vertex is assigned with the color . The antimagic rainbow vertex connection number of , denoted by , is the minimum colors taken over all rainbow vertex connection induced by antimagic rainbow edge labeling of . In this paper, we determined the exact value of the antimagic rainbow vertex connection number of path ( ), wheel ( ), friendship ( ), and fan ( ).
Supplier Selection Analysis Using Minmax Multi Choice Goal Programming Model
Authors: Dewi Novi Rustiana , Susanti Eka , Suprihatin Bambang , Cahyono Endro Setyo , Permata Anggun , Yanita Nurul Fadhila 
Published: November 2021

Production control, inventory and distribution is an important factor in trading activities. These three factors are discussed in a system called Supply Chain Management (SCM). Procurement of goods from a company or trading business related to suppliers. In some cases, there are several supplier that can be assessed by considering certain factors. In certain cases, the data from several factors that are considered are uncertainty, so the fuzzy approach can be used. The MINMAX Multi Choice Goal Programming model can be used to solve fuzzy supplier selection problems with linear membership function. It can be applied to selecting supplier of Brastagi Oranges. There are four suppliers, namely Jaya, Mako, Baros. Gina. There are three factor to consider, cost, quality and delivery. The decision maker select the best supplier for ordering 17000 kg Brastagi oranges. The results, the best supplier is Gina with an order quantity of 10000 kg and Mako with a total order of 7000 kg
The Ring Homomorphisms of Matrix Rings over Skew Generalized Power Series Rings
Authors: Faisol Ahmad , Fitriani Fitriani 
Published: November 2021

Let M_n (R_1 [[S_1,≤_1,ω_1]]) and M_n (R_2 [[S_2,≤_2,ω_2]]) be a matrix rings over skew generalized power series rings, where R_1,R_2 are commutative rings with an identity element, (S_1,≤_1 ),(S_2,≤_2 ) are strictly ordered monoids, ω_1:S_1→End(R_1 ),〖 ω〗_2:S_2→End(R_2 ) are monoid homomorphisms. In this research, a mapping τ from M_n (R_1 [[S_1,≤_1,ω_1]]) to M_n (R_2 [[S_2,≤_2,ω_2]]) is defined by using a strictly ordered monoid homomorphism δ:(S_1,≤_1 )→(S_2,≤_2 ), and ring homomorphisms μ:R_1→R_2 and σ:R_1 [[S_1,≤_1,ω_1]]→R_2 [[S_2,≤_2,ω_2]]. Furthermore, it is proved that τ is a ring homomorphism, and also the sufficient conditions for τ to be a monomorphism, epimorphism, and isomorphism are given.
Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level
Authors: Leary Shay , Gaudieri Silvana , Parker Matthew , Chopra Abha , James Ian , Pakala Suman , Alves Eric , John Mina , Lindsey Benjamin , Keeley Alexander , Rowland-Jones Sarah , Swanson Maurice , Ostrov David , Bubenik Jodi , Das Suman , Sidney John , Sette Alessandro ,   COVID-19 Genomics UK (COG-UK) consortium, De Silva Thushan , Phillips Elizabeth , Mallal Simon 
Published: November 2021

Background: Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host’s anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we examined the adjacent amino acid polymorphisms in the nucleocapsid (R203K/G204R) of SARS-CoV-2 that arose on the background of the spike D614G change and describe how strains harboring these changes became dominant circulating strains globally. Methods: Deep-sequencing data of SARS-CoV-2 from public databases and from clinical samples were analyzed to identify and map genetic variants and sub-genomic RNA transcripts across the genome. Results: Sequence analysis suggests that the 3 adjacent nucleotide changes that result in the K203/R204 variant have arisen by homologous recombination from the core sequence of the leader transcription-regulating sequence (TRS) rather than by stepwise mutation. The resulting sequence changes generate a novel sub-genomic RNA transcript for the C-terminal dimerization domain of nucleocapsid. Deep-sequencing data from 981 clinical samples confirmed the presence of the novel TRS-CS-dimerization domain RNA in individuals with the K203/R204 variant. Quantification of sub-genomic RNA indicates that viruses with the K203/R204 variant may also have increased expression of sub-genomic RNA from other open reading frames. Conclusions: The finding that homologous recombination from the TRS may have occurred since the introduction of SARS-CoV-2 in humans, resulting in both coding changes and novel sub-genomic RNA transcripts, suggests this as a mechanism for diversification and adaptation within its new host.
Pelatihan Peningkatan Kemampuan Guru untuk Mengidentifikasi Miskonsepsi Peserta Didik Pada Pembelajaran Kimia Bagi Guru Kimia Se-Kalimantan Selatan
Authors: Almubarak Almubarak , Mahdian Mahdian , Kusasi Muhammad , Suharto Bambang , Saadi Parham 
Published: November 2021

Pembelajaran kimia sangat sensitif terhadap perspektif peserta didik. Ketika peserta didik tidak diarahkan dengan tepat maka akan berpeluang munculnya miskonsepsi. Tujuan kegiatan Pengabdian kepada Masyarakat (PkM) ini adalah 1) mendeskripsikan cara meningkatkan kemampuan guru dalam mengidentifikasi miskonsepsi peserta didik, dan 2) efektivitas pelatihan yang dilakukan terhadap peningkatan kemampuan guru dalam mengidentifikasi miskonsepsi peserta didik. Pelatihan ini diikuti oleh guru SMA yang tergabung dalam MGMP guru kimia. Teknik pengumpulan data yaitu teknik dokumentasi, observasi, dan wawancara agar memeproleh informasi yang jelas dari para responden. Teknik analisis data menggunakan analisis kualitatif dengan tujuan untuk mendeskripsikan fenomena yang terjadi selama proses kegiatan. Hasil kegiatan PkM diperoleh bahwa cara untuk meningkatkan kemampuan guru dalam mengidentifikasi miskonsepsi peserta didik yakni, 1) mengembangkan suatu tes diagnostik berbasis pilihan ganda/essai, 2) melakukan tes diagnostik kepada peserta didik baik sebelum ataupun sesudah proses pembelajaran, dan 3) menyajikan materi kimia dengan mengintegrasi fenomena atau kehidupan sehari-hari. Kemudian, efektivitas pelatihan yang dilakukan terhadap peningkatan kemampuan guru dalam mengidentifikasi miskonsepsi peserta didik yakni dengan menyajikan konsep belajar kimia berbasis kimia representasi. Kegiatan ini menjadi salah satu strategi dalam mereduksi miskonsepsi peserta didik. Chemistry learning is very sensitive to students' perspectives. When students are not appropriately directed, there will be opportunities for misconceptions to arise. The objectives of this Community Service activity are 1) to describe how to improve the teacher's ability to identify student misconceptions, and 2) the effectiveness of the training carried out to increase the teacher's ability to identify student misconceptions. This training was attended by high school teachers who are members of the chemistry teacher MGMP. Data collection techniques are documentation, observation, and interview techniques to obtain clear information from the respondents. The data analysis technique uses qualitative analysis to describe the phenomena that occur during the activation process. The results of the community service activity showed that the ways to improve the teacher's ability to identify students' misconceptions were, 1) developing a multiple-choice/essay-based diagnostic test, 2) conducting diagnostic tests to students both before and after the learning process, and 3) presenting chemistry material by integrating phenomena of everyday life. Then, the effectiveness of the training carried out on improving the ability of teachers to identify students' misconceptions is by presenting the concept of learning chemistry based on representational chemistry. This activity is one of the strategies in reducing students' misconceptions.
Review of Single Centre Experience with Bronchial Thermoplasty in Obesity
Authors: RANDHAWA EKAMJEET , Shenoy Kartik 
Published: November 2021

Abstract
BackgroundBronchial thermoplasty (BT) is a bronchoscopic procedure that aims to reduce symptoms in patients with severe asthma by delivering controlled radiofrequency activations to reduce airway smooth muscle mass who are uncontrolled despite adequate therapy.ObjectiveTo evaluate response and outcomes of BT in asthma patients with obesity.MethodsA retrospective review of patients who had BT for severe asthma performed at our institution. We examined baseline differences in eosinophil, IgE levels, controller agent uses before and after BT, symptomatology and exacerbation rates post-procedure. A comparative analysis was done using t-test for unequal variables for those reported to have benefitted from the procedure against those who did not.ResultsIn total 23 patients were studied, 18 (78%) noted benefit from BT. Patients were predominantly female, 21/23 (91%) with average BMI of 37.9 and 35.3 kg/m2 in improved and not improved groups. Patients with improvement following completion of all three BT procedures were likely to be weaned off chronic oral steroids or biologicals, reduced albuterol uses, report a subjective improvement in symptoms or reduced exacerbations within 1 year following completion of procedures. There was a statistically significant average weight loss reduction in the improved group compared to not benefitted of 6.4kg versus a gain of 2.5kg; hospitalization rates for exacerbations were higher than those reported in the AIR2 and PAS2 studies at 43%.ConclusionBT can be beneficial for obese patients with a potential decrease in exacerbations and reduced oral corticosteroid dosage and an anticipated increased rate of post-procedure exacerbation hospitalization.
Evaluation of IMproving Palliative Care Education and Training Using Simulation in Dementia (IMPETUS-D) a Staff Simulation Training Intervention to Improve Palliative Care of People with Advanced Dementia Living in Nursing Homes: A Cluster Randomised Controlled Trial
Authors: Tropea Joanne , Nestel Debra , Johnson Christina E , Hayes Barbara J , Hutchinson Anastasia F , Brand Caroline A , Le Brian H , Blackberry Irene , Caplan Gideon A , Bicknell Ross , Hepworth Graham , Lim Wen K 
Published: November 2021

Abstract
BackgroundAccess to palliative and end-of-life care for people with dementia living in nursing homes is suboptimal. Nursing home staff require training in palliative care for dementia to equip them with knowledge and skills to deliver high quality care. ObjectiveThe primary aim was to evaluate the effectiveness of a simulation training intervention (IMPETUS-D) aimed at nursing home staff on reducing unplanned transfers to hospital and/or deaths in hospital among residents living with dementia.Design Cluster randomised controlled trial of nursing homes with process evaluation conducted alongside.Subjects & setting1304 people with dementia living in 24 nursing homes (12 intervention/12 control) in three Australian cities, their families and direct care staff. MethodsRandomisation was conducted at the level of the nursing home (cluster). The allocation sequence was generated by an independent statistician using a computer-generated allocation sequence.Staff from intervention nursing homes had access to the IMPETUS-D training intervention, and staff from control nursing homes had access to usual training opportunities. The predicted primary outcome measure was a 20% reduction in the proportion of people with dementia who had an unplanned transfer to hospital and/or death in hospital at 6-months follow-up in the intervention nursing homes compared to the control nursing homes. ResultsAt 6-months follow-up, 128 (21.1%) people with dementia from the intervention group had an unplanned transfer or death in hospital compared to 132 (19.0%) residents from the control group; odds ratio 1.14 (95% CI, 0.82-1.59). There were suboptimal levels of staff participation in the training intervention and several barriers to participation identified. ConclusionThis study of a palliative dementia care staff training intervention found no difference in the proportion of residents with dementia who had an unplanned hospital transfer. Implementation of the intervention was challenging and likely did not achieve adequate staff coverage to improve staff practice or resident outcomes.Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12618002012257. Registered 14/12/2018.
Evaluation of Child Emergency Department Utilization: Differences Between Refugee and Resident Children.
Authors: Baris Hatice Ezgi , Silahli Nicel Yildiz , Gul Nuriye Ayca , Qutranji Lubna , Goldhagen Jeffrey , Boran Perran 
Published: November 2021

Abstract
Objectives: Evaluation of emergency department (ED) utilization by Syrian refugee children will provide important information about their health care needs and utilization as a prerequisite for improving preventive health services and outcomes. We aimed to compare ED utilization of refugee and resident children in a tertiary university hospital in Istanbul, Turkey.Methods: Electronic medical records of Syrian refugee children ≤18 years old presenting to the ED between January 2013 and July 2019 were retrospectively reviewed and compared with the resident children.Results: The study population consisted of 7299 refugee and 690127 resident children admitted to the ED. Emergent cases were more frequent in Syrian refugees (2.2% vs 1.0% p<0.001). One third of Syrian children were under 12 months of age (31.0% vs 17.4%, p<0.001). Syrian children were more commonly hospitalized (7.9% vs 3.1% p<0.001). Rate of intensive care unit hospitalization (13.4% vs 9.4%, p=0.001) and neonatal hospitalization was higher in Syrians compared to resident children (29.3% vs 12.0%, p<0.001). Respiratory and gastrointestinal diseases were the most frequent diagnoses which were similar in both groups. Conclusion: Refugee children as compared to native children are more likely to present to the ED with high acuity conditions, at a younger age resulting in higher rates of inpatient admissions. Strategies to increase access to preventive health care services for young refugee children should be explored to decrease ED and hospital services and improve health outcomes.
Expression Analysis of Irisin During Different Differentiation Stages of Skeletal Muscle Cells
Authors: Yan Yi , Yang Ding , Wen Pei , Li Yilei , Ge Yufang , Ma Pei , Yuan Jiahui , Zhang Pengxiang , Zhu Zhiwei , Luo Xiaomao , Yu Xiuju , Wang Haidong 
Published: November 2021

Abstract
Background: As a newly discovered muscle factor secreted by skeletal muscle cells, irisin is a polypeptide fragment formed after hydrolysis by fibronectin type Ⅲ domain-containing protein 5 (FNDC5). Previous studies have shown that irisin has biological functions that promote beigeing of WAT, regulate glucose and lipid metabolism. However, the functions of irisin in muscle development and muscle fat metabolism remain unknown.Results: In order to study the expression of irisin in different growth stages of skeletal muscle, this study used SPF mice as experimental subjects to select skeletal muscle cells and muscle tissues of different developmental stages of mice. The expression of irisin precursor FNDC5 in different stages of cells and tissues was detected by western blotting and real-time fluorescent quantitative PCR, and the expression of FNDC5 in cells was detected by immunofluorescence. The results showed that FNDC5 was expressed in all stages of tissues and cells, but the expression was different at different stages. FNDC5 protein has the highest expression in muscle of sexually mature mice, followed by elderly mice and adolescent mice, and low expression in pups. Secondly, FNDC5 protein is mainly expressed in the cytoplasm and highest in muscle fibers. The myotubes were the second, and the lowest in C2C12 cells. Conclusions: This experiment can provide a theoretical basis for the subsequent study of irisin in skeletal muscle, and lay the foundation for targeted therapy of related diseases.
Improving Treatment Adherence and Control Rate of Patient with Hypertension Using Aweb-Based Management System in a Rural Community in China
Authors: Zhu Yanxia , Guo Liangm , Wu Tianran , Wu Xingli 
Published: November 2021

Abstract
The control rates of patients with hypertension remain extremely low in Chinese rural communities, therefor we aimed to improve treatment adherence and control rate for patients with hypertension by using a web-based management system, which included modeles of the user’s personal information, health education, adherence alerting, communication between physician and statistics analysis and data print functions. 350 patients with uncontrolled hypertension were included in the study through a multi-stage stratified sampling, and were divided radomis1y into the web-based intervention group and control group. Comparing with those in the control group, there was a significant improvement in the control rate of the blood pressure in the intervention group (93.7% vs 50.9%, p < 0.001) and a remarkable decrease in blood pressure (systolic blood pressure declined by 25.0 mmHg, < 0.001; diastolic blood pressure declined by 8.7 mmHg, p < 0.001) after 12 months follow-up. The medication adherence rate in intervention groups was improved significantly than that in the control group p < 0.01)，and the adherence scale correlated negatively with blood pressure (r=-0.518, P < 0.001), and positively correlated with control rate (0.623, P < 0.001). This study suggested that the web-based hypertension management system is worth spreading in rural areas in developing countries.
Spatio-temporal Analysis of Land Cover Changes in Al-Hubail Wetland (Kingdom of Saudi Arabia)
Authors: CHOUARI Walid 
Published: November 2021

Abstract
Land cover dynamics were analyzed temporally and spatially in Al-Hubail wetland (Al-Ahsa, Kingdom of Saudi Arabia) to determine the evolution of the environmental status of this biologically and ecologically interesting area in Saudi Arabia. Land cover changes were estimated for the next 41 years (1980-2021) using remote sensing data. For this analysis, three images from 1985 (Landsat 5 MSS) 2000 (Landsat 7 ETM+) and 2021 (Sentinel-2) were used to classify and detect changes. A machine learning algorithm was used and the images were classified into four main land cover classes: Water bodies, hydromorphic areas, vegetation and open ground. Change detection was performed for the year pairs 1985 to 2000 and 2000 to 2021. The results of this classification show that there was a significant increase in the area of hydromorphic areas and vegetation. The results were checked with a confusion matrix indicating an overall accuracy between 89.3 and 92.8%. The qualitative trend data show that the Al-Hubail wetland has changed significantly during the study period. Thus, a significant expansion of the wetland was observed in conjunction with an increase in agricultural drainage towards the wetland. This analysis shows the strong anthropogenic pressure on the area and highlights the need to strengthen the existing laws in order to preserve the local biodiversity in the long term. It suggests that more efforts should be made to effectively manage the water resources of the region.
Report On Complete Endpoints and Predictors of Response to Plasma Exchange – Results From a Randomized Controlled Trial in Septic Shock Patients
Authors: Stahl Klaus , Wand Philipp , Seeliger Benjamin , Schmidt Julius J. , Schmidt Bernhard M.W. , Sauer Andrea , Lehmann Felix , Budde Ulrich , Busch Markus , Wiesner Olaf , Welte Tobias , Haller Hermann , Wedemeyer Heiner , Putensen Christian , Hoeper Marius M. , Bode Christian , David Sascha , Schmidt W. 
Published: November 2021

Abstract
Background: Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients with septic shock. Prediction of clinical efficacy in specific sepsis treatments is fundamental for individualized sepsis therapy.Methods: In the original RCT patients with septic shock of < 24 h duration and norepinephrine (NE) requirement ≥ 0.4 μg/kg/min received standard of care (SOC) or SOC + one single TPE. Here we report all clinical and biological endpoints of this study. Subgroup analysis of NE reduction and 28-day mortality was performed to investigate characteristics that could be associated with clinical response.Results: Early hemodynamic stabilization was preserved in the TPE group for 24 hours and was accompanied by a reduction of lactate suggestive for shock reversal. A reduction of injurious mediators (such as PCT, vWF:Ag, Angpt-2, sTie-2) and a repletion of exhausted protective factors (such as AT-III, Protein C, ADAMTS-13) could be observed in the TPE but not in the SOC group. Significant NE reduction (> 50% from baseline) upon TPE occurred more often in patients with 1) a pulmonary focus of infection, 2) profound respiratory failure (pO2/FiO2<150 mmHg), 3) critical hemodynamic instability (NE > 0.6 μg/kg/min and lactate >0.4 mmol/l) as well as 4) substantial degree of organ failure (SOFA Score > 16) at randomization. Patients with a pulmonary focus of infection had a 28-day mortality of 15% in the TPE group while it was 42% in the SOC group. Conclusions: Adjunctive TPE is associated with the removal of injurious mediators and repletion of consumed protective factors altogether leading to preserved hemodynamic stabilization in refractory septic shock. It is We identified potential response predictors (lung focus, PF ratio < 150, higher SOFA score etc.) that might guide future designing of large RCTs that will further evaluate TPE with regard to hard endpoints. Trial registration: Retrospectively registered 18th January 2020 at clinicaltrials.gov (Identifier: NCT04231994), https://clinicaltrials.gov/ct2/show/NCT04231994?term=NCT04231994&draw=2&rank=1