bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistent anti-Dra in two pregnancies
Authors: Rahimi-Levene N. , Kornberg A. , Siegel G. , Morozov V. , Shinar E. , Asher O. , Levene C. , Yahalom V. 
Published: May 2021

Abstract
The Drori (Dra) antigen is one of the ten high-prevalence antigens of the Cromer blood system, which are carried on decay-accelerating factor (DAF, CD55). The Dr(a–) phenotype was first described in a 48-year-old Jewish woman from Bukhara. Her serum contained an antibody to a high-prevalence antigen named anti-Dra. Most known individuals with the Dr(a–) phenotype are Jews from the geographic area of Bukhara, but individuals from Japan have also been described. Antibodies in the Cromer blood group system, including anti-Dra, have never been reported to cause HDN. In most of the cases with anti-Dra examined in Israel, the antibodies have been subtyped as IgG2 and IgG4. This report is of a woman with Dr(a–) phenotype and an anti-Dra titer of 256 to 512 in her serum, observed during two successive pregnancies. At birth, the RBCs of the first- and second-born child were negative and positive in the DAT, respectively, and neither manifested clinical signs of HDN. The disappearance of Cromer system antibodies, including anti-Dra in midpregnancy, has been described in a previous study. In that study, it was theorized that the antibodies in the serum of the women were adsorbed onto placental DAF. The finding of a high anti-Dra titer in two successive pregnancies in this patient, with a positive DAT for the RBCs of one of the two babies at term, differs from published reports, suggesting that a different mechanism might be involved.
Immunohematology

2005;21:126–128.
Review: the Kell, Duffy, and Kidd blood group systems
Authors: Westhoff C.M. , Reid M.E. 
Published: May 2021

Abstract
After the discovery (over 50 years ago) that the IAT could be applied to the detection of antibodies to blood group antigens, there was a rapid increase in the identification of alloantibodies that caused transfusion reactions or HDN. After Rh, antibodies in the Kell, Duffy, and Kidd blood group systems were the next in clinically significant antibodies to be revealed. Much of what has been learned about these blood groups since the journal Immunobematology issued its first edition has to do with the proteins, the genes, and the molecular basis for the antigens. What has not changed is that, after ABO and Rh, antibodies to antigens in these three systems are still the most clinically significant. They will form the basis of this review.
Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery
Authors: Shariatmadar S. , Storry J.R. , Sausais L. , Reid M.E. 
Published: May 2021

Abstract
Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immune-mediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient’s DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.
Review: immune thrombocytopenic purpura: an update for immunohematologists
Authors: Sandler S.G. 
Published: May 2021

Abstract
Immune thrombocytopenic purpura (ITP) is an acquired disease in which autoantibodies to platelets cause their sequestration and destruction by mononuclear macrophages, principally in the spleen. If increased production of platelets by megakaryocytes does not compensate for platelet destruction, the number of circulating platelets decreases (thrombocytopenia), resulting in a characteristic bleeding tendency (purpura). While most children with the disease experience a relatively short and benign clinical course, ITP in adults often lasts more than 6 months (chronic ITP) and is resistant to conventional treatment (corticosteroids, intravenous immune globulin, or splenectomy). The goal of medical management is to increase the platelet count to a safe level, without the risks of bacterial infections associated with splenectomy or toxicity from prolonged corticosteroid therapy. Splenectomy increases platelet counts in hours to days in most patients with acute ITP, but nearly 50 percent experience recurrent thrombocytopenia by 5 years postsplenectomy.
The sensitivity, specificity, and clinical relevance of gel versus tube DATs in the clinical immunology laboratory
Authors: Paz N. , Itzhaky D. , Ellis M.H. 
Published: May 2021

Abstract
The DAT is a test used to demonstrate in vivo antibody and/or complement coating of RBCs. Typically, the DAT is performed in test tubes; however, recently a number of commercially available tests using gel-filled microtubes have become available. Few data comparing the sensitivity of these test media are available. To compare the rate of detection of a positive DAT performed in test tubes versus in gel-filled microtubes and to assess the clinical significance of the results in patients undergoing evaluation of anemia, we tested 310 consecutive EDTA-anticoagulated blood samples from adult patients. The samples were analyzed using both the conventional tube technique and a gel-based assay (DiaMed®; Cressier sur Morat, Switzerland). Test results were expressed as either positive or negative. When a positive result by either technique was encountered, the treating physician was interviewed to determine whether the result warranted further patient investigation or treatment. In 268 out of 310 cases the DAT was negative by both methods. Of the 42 patients with a positive DAT, the test was positive by both methods in 18 patients. In the remaining 24 cases the DAT was positive by the gel test only. In all cases positive by both techniques the test result affected patient management. Of the 24 cases that were positive only by gel test, 3 were judged to be clinically significant. In this study, the gel test was more sensitive than the tube technique for performance of the DAT. However, the clinical significance of a DAT positive only by a gel test is doubtful. We believe that use of the gel-based DAT should be more extensively evaluated before it is adopted as a standard technique in general clinical laboratory practice.
Effects of arsenic on the distribution and mode of occurrence of gold during fluid-pyrite interaction: A case study of pyrite from the Qiucun gold deposit, China
Authors: Zhang He , Cai Yuanfeng , Sha Gang , Brugger Joël , Pring Allan , Ni Pei , Qian Gujie , Luo Zhenjiao , Zhang Yang , Tan Wei 
Published: May 2021

Abstract
This paper presents the results of an investigation of the incorporation of Au within pyritic ore from the Qiucun epithermal Au deposit, China. The new data provide insights into the mode of occurrence of Au during fluid-rock interactions within epithermal systems. The distribution and mode of occurrence of Au within arsenian pyrite were investigated using a chemical and structural characterization-based approach combining laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) trace element analysis, megapixel synchrotron X-ray fluorescence analysis (MSXRF), and atom probe tomography (APT). The resulting data indicate that invisible Au is present at elevated concentrations in the form of a homogeneous solid solution within As-rich pyrite domains, which yields Au concentrations that positively correlate with As. Arsenic-induced lattice defects, such as stacking faults and the expansion of the pyrite unit cell, provide evidence of the effect of As on the incorporation of Au into pyrite. The nucleation and crystallization of electrum preferentially occurred at the fluid-pyrite reaction interface or along fractures and grain boundaries within the pre-existing pyrite. This study indicates that changes in physicochemical conditions (e.g., temperature, pH, and sulfur fugacity) during fluid-pyrite interactions are key controls on the development of nanometer- or micrometer-scale clusters of gold. The systematic compositional and textural observations documented in this study provide new insights into the mechanisms responsible for the different modes of occurrence of Au (ionic vs. particulate) and enable us to further understand the processes involved in the formation of Au mineralization.
Isotopic tracers of sources of water for springs from the Edwards Aquifer, Central Texas, USA
Authors: Tian Lijun , Gao Yongli , Yang Guang , Schwartz Benjamin , Cai Binggui , Ray Christopher , Li Yunxia , Wu Haibin 
Published: May 2021

Abstract
The Edwards Aquifer (EA) in Central Texas provides water supply for over two million people and contains springs that are hydrologically and ecologically important to the region. The residence time of groundwater in the EA ranges from a few days to many thousands of years, since water in the aquifer is contained and transported within both matrix porosity and large conduits. In this study, stable isotopes of water from five springs are investigated for tracing the origin of water and hydrological processes in the EA system during 2017–2019. There is a quick response of the isotopic signals measured at these springs to changes in the isotopic compositions of precipitation. By utilizing an isotope mixing model, we have identified sources of water for these springs with a bi-modal distribution of groundwater supply in the EA: water supplied from deep groundwater with a longer residence time (an average of 67%) and supplemental epikarst interflow with a shorter residence time (an average of 33%). The evolution of hydrochemical water types from HCO3–Ca to HCO3·Cl–Ca·Mg along the EA flowpaths indicates that inputs from epikarst interflow are greater in springs within the artesian zone than the springs within the contributing zone.
Heterogeneous Metal Catalysis for the Environmentally Benign Synthesis of Medicinally Important Scaffolds, Intermediates, and Building Blocks
Authors: Ilamanova Maysa , Mastyugin Maxim , Schäfer Christian , Kokel Anne , Török Béla 
Published: May 2021

:
This account provides a broad overview of the application of solid metal catalysts
in synthetic chemistry with a focus on the synthesis of medicinally important scaffolds or
building blocks. Heterogeneous catalysis is a fundamental contributor to green or sustainable
synthesis. Despite this, many synthetic chemists overwhelmingly focus on homogeneous
methods, and due to their unfamiliarity with solid catalysts, many would not consider using
them. The primary purpose of this work is to bring solid catalysts and their application
possibilities to the attention of synthetic chemists in a format that focuses on reactions, thus
building a bridge between the two sides for the benefit of sustainable applications and,
eventually, the whole society. The two major parts of this account describe the common types
of solid metal catalysts and the applications of these catalysts in sustainable synthesis. The
first part gives an overview of the major types of solid metal catalysts, including common hydrogenation catalysts to
metal nanoparticles. The second and more extensive part illustrates the use of these catalysts in a thematic order
based on reaction types, including hydrogenation, hydrogenolysis, oxidation, metathesis, cross-coupling reactions,
and hydroformylation.
Isolation of PHB Producing Yeast from Soil and its Quantification
Authors: Varghese Varsha , Shylaja Sheela 
Published: May 2021

Background:
Plastics are widely used in almost every manufacturing industry ranging from automobiles to
medicine. Plastics take years to get degrade and have become a threat to the environment. Therefore there is a necessity to
use biodegradable plastics in place of such non-biodegradable plastics. Polyhydroxybutyrate or PHB is a type of biopolymer
which has similar properties to that of synthetic plastics and is susceptible to degradation by microbes in the environment
itself. PHB is produced in microorganisms such as bacteria or yeast under stress conditions. As the yeast has a large
cell size, it can accumulate more PHB than bacteria and is also physiologically flexible, in addition to the advantage of using
yeast rather than the bacterial cell for the production of PHB. Therefore, the aim of the study was to isolate PHB producing
yeast strain from the agricultural field.

Methods:
Primary screening of isolates was performed using Sudan Black B for PHB production. The extraction of PHB
was done using sodium hypochlorite digestion method. The quantification of extracted PHB was done by UV-VIS spectroscopy.

Results:
The percentage and amount of PHB extracted were found to be 13.4 % per biomass and 1.6mg/ml, respectively.

Conclusion:
A quite amount of PHB was able to be extracted from yeast isolate. As a future perspective, the enhancement
of PHB production can be done using agricultural residues like sugarcane bagasse, corn cob, teff, banana peel, etc.
Tingkat Pengetahuan Petugas Pengelola Vaksin dan Evaluasi Pengelolaan Vaksin di Puskesmas Kabupaten Sleman
Authors: Prasetyo Septimawanto Dwi , Vidia Ningrum Bunga Carina , Irianingrum Elizabeth Henny , Oktarini Farras Talitha , Nizza Ismah 
Published: May 2021

Vaksin merupakan produk biologis yang sangat rentan sehingga diperlukan pengelolaan vaksin yang tepat untuk menjaga kualitas vaksin. Kualitas vaksin perlu dipertahankan sejak vaksin diproduksi sampai sebelum diberikan kepada pasien. Pengelolaan vaksin yang tepat juga perlu didukung oleh petugas yang terlatih dan bertanggung jawab. Penelitian ini bertujuan untuk mengetahui gambaran pengelolaan vaksin dan tingkat pengetahuan pengelola vaskin di Puskesmas Kabupaten Sleman. Penelitian ini merupakan penelitian observasional yang bersifat deskriptif dengan desain cross-sectional. Data yang dikumpulkan berupa data kuantitatif dan kualitatif yang diperoleh dari enam puskesmas di Kabupaten Sleman. Pengumpulan data diperoleh dari observasi langsung, wawancara, dan pengisian kuesioner. Data kemudian dianalisis secara statistik berupa persentase. Data disajikan dalam bentuk tabel dan narasi yang menggambarkan pengelolaan vaksin dan tingkat pengetahuan pengelola vaksin. Pada penelitian ini diketahui bahwa tingkat pengetahuan petugas pengelola vaksin tergolong baik. Aspek tingkat pengetahuan yang tergolong baik adalah aspek penyimpanan, pelayanan, pencatatan dan pelaporan vaksin, sedangkan aspek perencanaan, pengendalian dan distribusi vaksin tergolong kurang baik. Pada penelitian ditemukan bahwa semua aspek pengelolaan vaksin sudah tergolong baik, namun masih ditemukan beberapa hal yang kurang baik. Sebanyak 28% puskesmas mengalami over stock vaksin dan 40% puskesmas belum menyimpan vaksin dengan memberi jarak antar kotaknya. Masih terdapat 72% puskesmas memiliki vaksin yang kedaluwarsa dan 36% belum mencatat suhu vaksin pada saat libur.
“A menor distância entre dois pontos...”: sobre o conceito de dobra enquanto componente da visão do mundo e técnica de escrita em Maria Gabbriela Llansol
Authors: Sousa Filho Aderaldo Ferreira de 
Published: May 2021

Neste artigo, propomos uma leitura do processo de escrita de Maria Gabriela Llansol a partir do conceito de dobra, tal como desenvolvido por Deleuze em A Dobra, Leibniz e o Barroco. Este conceito remete a um traço característico do Barroco, mas que pode, contudo, ultrapassar seus limites históricos. No Barroco, a dobra define tanto um recurso estético como uma componente de sua visão de mundo, pois garante um efeito de imanência que contradiz tradicional oposição entre o material e o imaterial, entre o visível e o inteligível. Na escrita da autora portuguesa, a dobra se nos apresenta como um elemento fundamental, tanto na caracterização de sua visão do mundo como na técnica que ela desenvolve, opondo a textualidade à narratividade. Assim, o conceito resumiria a percepção do real através das dobras que esta escrita evoca, assim como o que a autora caracteriza como a técnica da sobreimpressão, na qual a linguagem abriria caminho a diversos níveis de realidade, unindo-os e indiscernindo seus limites, tal como o Barroco faz com o plano divino e o terreno. Procuramos demonstrar ainda como este conceito se aplica à própria escrita, a partir da proliferação de imagens (que a autora opõe a metáfora) que configura as cenas fulgor.
De imagem em imagem
Authors: Martelo Rosa Maria 
Published: May 2021

Há 50 anos, a poesia portuguesa atribuía à imagem um papel matricial. Em registos muito diversos, os poemas valorizavam formas de experimentação discursiva nas quais a imagem surgia como motor de conhecimento, e mesmo de epifania. Interrogava-se a visão e as visões (Fiama), ou combinava-se o visionarismo e a falência da visão (Luiza Neto Jorge). Pretendia-se pensar “no âmago das imagens” (Fiama, novamente), ou aguardava-se “o dom apenas de uma imagem”, como diria mais tarde um verso de Herberto Helder. Retrospectivamente, ao recordar os anos de Poesia 61, Gastão Cruz resumiu esta inflexão em poucas palavras: “era de imagens que nós achávamos que a poesia vivia”. Sendo incontáveis os sentidos da palavra imagem, valerá a pena perguntar que imagens eram estas. A que se devia o seu protagonismo? Como funcionavam? Que mundos pretendiam descobrir? Eis as questões que procuro equacionar, acentuando a condição “profusa”, plural, da imagem poética ainda quando pensada como uma imagem (no singular).
"Maria"&José: o lirismo elegíaco de Craveirinha
Authors: Leite Ana Mafalda 
Published: May 2021

O artigo analisa de que modo a elegia é o género fundamental na composição dos poemas de Maria, de José Craveirinha. A saudade e a dor levam o sujeito poético a transmutar-se no “outro” e a feminilizar as temática evocadas.
Pembaharuan Hukum Pidana Tentang Pertanggungjawaban Pidana Terhadap Pengguna Jasa Prostitusi Di Indonesia
Authors: Utami Kania Mulia , Ridwan Ridwan , Asphianto Aan 
Published: May 2021

ABSTRAK
Penelitian ini bertujuan untuk untuk membahas tentang pertanggungjawaban pidana terhadap pengguna jasa prostitusi dalam perspektir perbandingan Indonesia dan Swedia. Tipe penelitian ini adalah penelitian normatif. Hasil Penelitian ini menghasilkan kesimpulan bahwa menurut hukum positif di Indonesia tidak adanya pertanggungjawaban pidana yang dapat menjerat pengguna jasa prostitusi secara jelas dan tegas sehingga belum efektif dan menyebabkan tidak maksimalnya dalam penanggulangan prostitusi itu sendiri. Apabila tidak ada aturan hukum di indonesia yang mengatur tentang pengguna jasa prostitusi, maka para pengguna jasa prostitusi akan merasa aman dan tetap leluasa membeli jasa untuk kepuasan mereka semata. Berbeda dengan kebijakan hukum di Swedia yang sudah memiliki aturan yang dapat menjerat hukum terhadap pengguna jasa prostitusi. Pertanggungjawaban pidana dalam hal ini sangatlah diperlukan pengaturan yang jelas dan tegas, oleh karena itu diperlukan pembaharuan hukum pidana terkait pertanggungjawaban pidana bagi para pengguna jasa prostitusi di Indonesia.
ABSTRACT
This article aims to discuss criminal liability on prostitution clients criminal liability in a comparative study between indonesia and swedish . This research is normative. The result of this study lead to the conclusion that based on the positive law in Indonesia there is no criminal liability that can ensnare the users of prostitution service clearly and decisively so there is not effective and not too optimum of handling prostitution. If there is no legal rule in Indonesia that regulates the users of prostitution services, then the users of prostitution services will feel safe and remain free to buy services for their satisfaction. Unlike the legal policy in Sweden which already has rules that can ensnare the law against prostitution service users. Criminal liability in this case is clearly and strictly needed, therefore, criminal law reform is needed related to criminal liability for users of prostitution services in Indonesia.
Peningkatan Aktivitas dan Hasil Belajar Materi Perkembangbiakan Makhluk Hidup Melalui Model Pembelajaran Problem Based Instruction dengan Media Visual pada Siswa Kelas VI SD
Authors: Sulistiyo Sulistiyo 
Published: May 2021

Penelitian bertujuan untuk meningkatkan aktivitas dan hasil belajar IPA materi perkembangbiakan makhluk hidup melalui model pembelajaran Problem Based Instruction dengan Media Visual pada siswa kelas VI SD 1 Undaan Tengah semester I tahun pelajaran 2018/2019. Prosedur pelaksanaan dan implementasi di lokasi penelitian terbagi dalam dua siklus. Siklus I dilakukan dua kali pertemuan dan begitu juga siklus II dilakukan dua kali pertemuan. Hasil penelitian ini menunjukkan bahwa aktivitas siswa pada siklus I memperoleh rata-rata skor 20,59 atau sebesar 73,56% (sedang), siklus II meningkat menjadi 25,19 atau sebesar 89,97% (sangat tinggi). Pada akhir tindakan siklus I nilai rata-rata yang diperoleh 72,62 atau sebesar 71,43% mengalami peningkatan 23,81% dari kondisi awal. Pada siklus II diperoleh nilai rata-rata 79,76 atau sebesar 85,71% sehingga mengalami peningkatan sebesar 14,28% dari siklus I. disimpulkan bahwa penerapan model pembelajaran problem based instruction dengan media visual dapat meningkatkan aktivitas dan hasil belajar perkembangbiakan makhluk hidup pada siswa kelas VI SD 1 Undaan Tengah Kudus.
PENINGKATAN KOMPETENSI PEDAGOGIK GURU DI DALAM MENYUSUN RPP MELALUI WORKSHOP PENYUSUNAN RPP D MASA PANDEMI COVID 19 PADA SEKOLAH BINAAN MANAJERIAL SMA KABUPATEN BULELENG DENGAN METODA DARING DAN LURING TAHUN PELAJARAN 2020/2021
Authors: Widawati Ketut 
Published: May 2021

Penelitian ini dilatar belakangi oleh (1) Masih lemahnya pemahaman guru dalam menyusun RPP dimasa pandemi covid 19 (b) menyikapi regulasi covid 19 pembelajaran dari rumah (BDR). Dengan tujuan untuk mengetahui (a) melalui workshop penyusunan RPP dimasa pandemi covid 19 dalam meningkatkan kompetensi pedagogik guru pada sekolah binaan managerial SMA dalam menyusun RPP, dan (b) Untuk meningkatkan pemahaman guru dalam menyikapi regulasi covid 19 pembelajaran dari rumah (BDR) melalui penyusunan RPP dimasa pandemi covid 19 , digunakan metode penelitian tindakan sekolah (PTS) dengan dua siklus yang masing-masing siklusnya terdiri dari tahap (1) perencanaan, (2) pelaksanaan tindakan perbaikan, (3) observasi, dan (4) refleksi. Hasil penelitian menunjukkan bahwa (a) terjadi peningkatan kompetensi pedagogik guru dalam menyusun RPP melalui workshop penyusunan RPP dimasa pandemi covid 19 pada sekolah binaan manajerial SMA Kabupaten Buleleng. Penilaian melalui Rubrik Penilaian Rencana Pelaksanaan Pembelajaran (RPP) pada siklus 1 yang mencapai nilai 24, berada pada katagori baik, dan hasil penilaian pada siklus 2 yang mencapai nilai 31, berada pada katagori sangat baik, dan (b) Pemahaman guru dalam menyikapi regulasi belajar dari rumah mengikuti melalui workshop penyusunan RPP dimasa pandemi covid 19 pada siklus 2 lebih baik daripada pada saat siklus 1. Penilaian melalui Rubrik Penilaian Aktivitas Guru dalam Menyusun Rencana Pelaksanaan Pembelajaran (RPP) selama Kegiatan MGMP pada siklus 1 yang mencapai nilai 30 atau tergolong baik, dan pada siklus 2 mencapai nilai 35, yang berarti tergolong sangat baik. Berdasarkan hasil penelitian ini penulis merekomendasikan kepada guru yang ada di sekolah binaan manajerial SMA Kabupaten Buleleng agar mengoptimalkan perannya sebagai perencana, pengorganisir, dan penilai pembelajaran, kepada kepala sekolah agar memfasilitasi guru untuk meningkatkan kompetensi pedagogiknya sehingga berimbas pada peningkatan mutu pendidikan di sekolah, kepada Dinas Pendidikan Kabupaten Buleleng, Dinas Pendidikan Kepemudaan dan Olahraga Provinsi Bali dan Depdiknas agar memfasilitasi peningkatan kompetensi guru dengan mengikutsertakannya dalam berbagai diklat sehingga dapat meningkatkan mutu pendidikan di Kabupaten Buleleng maupun Bali khususnya dan di Indonesia pada umumnya.