bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits
Authors: Meeks Karlijn A. C. , Bentley Amy R. , Gouveia Mateus H. , Chen Guanjie , Zhou Jie , Lei Lin , Adeyemo Adebowale A. , Doumatey Ayo P. , Rotimi Charles N. 
Published: October 2021

Abstract
Background
A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits, we investigated the genetic architecture of a large panel of obesity- related cytokines and hormones among Africans with replication analyses in African Americans.

Methods
We performed genome-wide association studies (GWAS) in 4432 continental Africans, enrolled from Ghana, Kenya, and Nigeria as part of the Africa America Diabetes Mellitus (AADM) study, for 13 obesity-related cytokines and hormones, including adipsin, glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), interleukin-1 receptor antagonist (IL1-RA), interleukin-6 (IL-6), interleukin-10 (IL-10), leptin, plasminogen activator inhibitor-1 (PAI-1), resistin, visfatin, insulin, glucagon, and ghrelin. Exact and local replication analyses were conducted in African Americans (n = 7990). The effects of sex, body mass index (BMI), and T2D on results were investigated through stratified analyses.

Results
GWAS identified 39 significant (P value < 5 × 10−8) loci across all 13 traits. Notably, 14 loci were African-ancestry specific. In this first GWAS for adipsin and ghrelin, we detected 13 and 4 genome-wide significant loci respectively. Stratified analyses by sex, BMI, and T2D showed a strong effect of these variables on detected loci. Eight novel loci were successfully replicated: adipsin (3), GIP (1), GLP-1 (1), and insulin (3). Annotation of these loci revealed promising links between these adipocytokines and cardiometabolic outcomes as illustrated by rs201751833 for adipsin and blood pressure and locus rs759790 for insulin level and T2D in lean individuals.

Conclusions
Our study identified genetic variants underlying variation in multiple adipocytokines, including the first loci for adipsin and ghrelin. We identified population differences in variants associated with adipocytokines and highlight the importance of stratification for discovery of loci. The high number of African-specific loci detected emphasizes the need for GWAS in African-ancestry populations, as these loci could not have been detected in other populations. Overall, our work contributes to the understanding of the biology linking adipocytokines to cardiometabolic traits.
Chronic intracranial subdural hematoma after spinal anesthesia for a cesarean section: a case report
Authors: Bekele Delayehu , Bayable Mehari , Bedane Alemayehu 
Published: October 2021

Abstract
Background
Subdural hematoma is a rare, potentially devastating, yet curable complication of spinal anesthesia. Differentiation between post-dural puncture headache and subdural hematoma can be difficult, resulting in a delay in diagnosis.

Case presentation
We present a 28-year-old Ethiopian female patient who underwent elective cesarean section under spinal anesthesia and returned to the emergency department after 1 month with a worsening headache. Brain computed tomography revealed a chronic subdural hematoma with a significant midline shift. The patient recovered completely after surgical evacuation.

Conclusions
A high index of suspicion and close attention to the pattern and characteristics of the headache, coupled with a meticulous neurologic examination and neuroimaging, can help to achieve timely diagnosis of this serious entity. Investigation with head computed tomography or magnetic resonance imaging is vital.
An efficient population-based multi-objective task scheduling approach in fog computing systems
Authors: Movahedi Zahra , Defude Bruno , Hosseininia Amir mohammad 
Published: October 2021

AbstractWith the rapid development of Internet of Things (IoT) technologies, fog computing has emerged as an extension to the cloud computing that relies on fog nodes with distributed resources at the edge of network. Fog nodes offer computing and storage resources opportunities to resource-less IoT devices which are not capable to support IoT applications with computation-intensive requirements. Furthermore, the closeness of fog nodes to IoT devices satisfies the low-latency requirements of IoT applications. However, due to the high IoT task offloading requests and fog resource limitations, providing an optimal task scheduling solution that considers a number of quality metrics is essential. In this paper, we address the task scheduling problem with the aim of optimizing the time and energy consumption as two QoS parameters in the fog context. First, we present a fog-based architecture for handling the task scheduling requests to provide the optimal solutions. Second, we formulate the task scheduling problem as an Integer Linear Programming (ILP) optimization model considering both time and fog energy consumption. Finally, we propose an advanced approach called Opposition-based Chaotic Whale Optimization Algorithm (OppoCWOA) to enhance the performance of the original WOA for solving the modelled task scheduling problem in a timely manner. The efficiency of the proposed OppoCWOA is shown by providing extensive simulations and comparisons with the original WOA and some existing meta-heuristic algorithms such as Artificial Bee Colony (ABC), Particle Swarm Optimization (PSO), and Genetic Algorithm (GA).
Multivariate analysis of factors associated with first-pass success in blind placement of a post-pyloric feeding tube: a retrospective study
Authors: Kurisawa Kohei , Yokose Masashi , Tanaka Hiroyuki , Mihara Takahiro , Takaki Shunsuke , Goto Takahisa 
Published: October 2021

Abstract
Background
Trans-jejunal nutrition via a post-pyloric enteral feeding tube has a low risk of aspiration or reflux; however, placement of the tube using the blind method can be difficult. Assistive devices, such as fluoroscopy or endoscopy, are useful but may not be suitable for patients with hemodynamic instability or severe respiratory failure. The aim of this study was to explore factors associated with first-pass success in the blind placement of post-pyloric enteral feeding tubes in critically ill patients.

Methods
Data were obtained retrospectively from the medical records of adult patients who had a post-pyloric enteral feeding tube placed in the intensive care unit between January 1, 2012, and December 31, 2018. Logistic regression analysis was performed to assess the association between first-pass success and the independent variables. For logistic regression analysis, the following 13 variables were defined as independent variables: age, sex, height, fluid balance from baseline, use of sedatives, body position during the procedure, use of cardiac assist devices, use of prokinetic agents, presence or absence of intestinal peristalsis, postoperative cardiovascular surgery, use of renal replacement therapy, serum albumin levels, and position of the greater curvature of the stomach in relation to spinal levels L1 − L2.

Results
Data obtained from 442 patients were analyzed. The first-pass success rate was 42.8% (n = 189). Logistic regression analysis demonstrated that the position of the greater curvature of the stomach cephalad to L1 − L2 was only associated with successful placement (odds ratio for first-pass success, 0.62; 95% confidence interval: 0.40 − 0.95).

Conclusions
In critically ill patients, the position of the greater curvature of the stomach caudal to L1 − L2 may be associated with a lower first-pass success rate of the blind method for post-pyloric enteral feeding tube placement. Further studies are needed to verify our results because the position of the stomach was estimated by radiographs after enteral feeding tube placement.
Trial registration: University Hospital Medical Information Network Clinical Trials Registry (UMIN000036549; April 20, 2019).
A model for the co-evolution of dynamic social networks and infectious disease dynamics
Authors: Nunner Hendrik , Buskens Vincent , Kretzschmar Mirjam 
Published: October 2021

AbstractRecent research shows an increasing interest in the interplay of social networks and infectious diseases. Many studies either neglect explicit changes in health behavior or consider networks to be static, despite empirical evidence that people seek to distance themselves from diseases in social networks. We propose an adaptable steppingstone model that integrates theories of social network formation from sociology, risk perception from health psychology, and infectious diseases from epidemiology. We argue that networking behavior in the context of infectious diseases can be described as a trade-off between the benefits, efforts, and potential harm a connection creates. Agent-based simulations of a specific model case show that: (i) high (perceived) health risks create strong social distancing, thus resulting in low epidemic sizes; (ii) small changes in health behavior can be decisive for whether the outbreak of a disease turns into an epidemic or not; (iii) high benefits for social connections create more ties per agent, providing large numbers of potential transmission routes and opportunities for the disease to travel faster, and (iv) higher costs of maintaining ties with infected others reduce final size of epidemics only when benefits of indirect ties are relatively low. These findings suggest a complex interplay between social network, health behavior, and infectious disease dynamics. Furthermore, they contribute to solving the issue that neglect of explicit health behavior in models of disease spread may create mismatches between observed transmissibility and epidemic sizes of model predictions.
Dynamic Plus-Delta: an agile debriefing approach centred around variable participant, faculty and contextual factors
Authors: Kainth Ranjev 
Published: October 2021

AbstractThe current coronavirus pandemic has necessitated rapid intensive care infrastructure expansion with corresponding demand for training healthcare staff. At the NHS Nightingale Hospital, London, the staff underwent a training programme prior to entering the clinical environment with simulation being a core component. This paper describes the rationale for choosing an initial debriefing model which evolved overtime to consider multiple contextual factors: demands of the clinical environment, the diverse participants and their learning needs, the variable experience of faculty, and the dynamic nature of available debriefing time. The new approach, termed here as the Dynamic Plus-Delta model, blends the traditional Plus-Delta approach with specific dynamic elements which considers the unique demands of rapidly training large number of staff. We outline the core features of this model and detail specific considerations around psychological safety. This debriefing approach can be used in similar simulation intervention settings where rapid training of participants is required with multiple and varying contextual factors.
Factor structure, measurement invariance and psychometric properties of the Quality of Life Scale WHOQOL-BREF in the Ecuadorian context
Authors: Lima-Castro Sandra , Arias-Medina Paúl , Bueno-Pacheco Alexandra , Peña-Contreras Eva , Aguilar-Sizer Mónica , Cabrera-Vélez Marcela 
Published: October 2021

AbstractBackgroundThe short version of the World Health Organization Quality of Life questionnaire (WHOQOL-BREF) is a popular instrument used to assess quality of life. The objective of this study was to evaluate the following psychometric properties: structural validity, convergent validity, internal consistency, and measurement invariance across sex of the WHOQOL-BREF in a sample of Ecuadorian adults.MethodsWe used a sample of undergraduates (n= 987) to assess the WHOQOL-BREF original four-factor structure, a model with correlated factors, a hierarchical model, and two models resulting from the exploratory factor analysis and exploratory graph analysis. All the models were evaluated using confirmatory factor analysis.ResultsThe results of the exploratory factor analysis and exploratory graph analysis suggest that the items are organized into four factors, although differently from the original version and the orthogonality assumption is not maintained. The confirmatory factor analysis shows that the original WHOQOL-BREF structure with correlated factors presents adequate psychometric properties. However, we propose a four-factor structure that has the best psychometric properties and adequate internal consistency. The results of the measurement invariance show that strict and strong invariance is achieved between men and women. Convergent validity analysis reveals moderate correlations with self-esteem, resilience, and social support.ConclusionsDespite the original version of the WHOQOL-BREF with correlated factors has acceptable psychometric properties in the Ecuadorian context, we propose a version with a different organization of its items, which is consistent with the findings of other investigations.
Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI
Authors: Urushihata Takuya , Takuwa Hiroyuki , Takahashi Manami , Kershaw Jeff , Tachibana Yasuhiko , Nitta Nobuhiro , Shibata Sayaka , Yasui Masato , Higuchi Makoto , Obata Takayuki 
Published: October 2021

Abstract
Background
Aquaporin-4 is a membrane channel protein that is highly expressed in brain astrocytes and facilitates the transport of water molecules. It has been suggested that suppression of aquaporin-4 function may be an effective treatment for reducing cellular edema after cerebral infarction. It is therefore important to develop clinically applicable measurement systems to evaluate and better understand the effects of aquaporin-4 suppression on the living body.

Methods
Animal models of focal cerebral ischemia were created by surgically occluding the middle cerebral artery of wild-type and aquaporin-4 knockout mice, after which multi-b-value multi-diffusion-time diffusion-weighted imaging measurements were performed. Data were analyzed with both the apparent diffusion coefficient (ADC) model and a compartmental water-exchange model.

Results
ADCs were estimated for five different b value ranges. The ADC of aquaporin-4 knockout mice in the contralateral region was significantly higher than that of wild-type mice for each range. In contrast, aquaporin-4 knockout mice had significantly lower ADC than wild-type mice in ischemic tissue for each b-value range. Genotype-dependent differences in the ADC were particularly significant for the lowest ranges in normal tissue and for the highest ranges in ischemic tissue. The ADCs measured at different diffusion times were significantly different for both genotypes. Fitting of the water-exchange model to the ischemic region data found that the water-exchange time in aquaporin-4 knockout mice was approximately 2.5 times longer than that in wild-type mice.

Conclusions
Multi-b-value multi-diffusion-time diffusion-weighted imaging may be useful for in vivo research and clinical diagnosis of aquaporin-4-related diseases.
Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
Authors: Van Bogaert C. , Mathey C. , Vierasu I. , Trotta N. , Rocq L. , Wolfromm A. , De Wilde V. , Goldman S. 
Published: October 2021

AbstractA 73-year-old man with a history of marginal zone lymphoma was admitted to the emergency room for diplopia and ipsilateral headache. The Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) demonstrated intense and symmetrical hypermetabolism of the cavernous sinuses, and hypermetabolic lesions diffusely in the lymph nodes and bones. The diagnosis of high-grade relapse of lymphomatous disease was made. In this context, the homogenous and symmetric lesion of the cavernous sinuses, without any other encephalic or meningeal lesions, raised the hypothesis of a paraneoplastic origin. A plausible paraneoplastic link between the neuro-ophthalmological lesion and the malignant disorder is IgG4-related disease, a condition that may be associated with lymphoma. As in our case, this diagnosis is often presumptive because histopathological confirmation is difficult to obtain.
Exploring BIS credit-to-GDP gap critiques: the Swiss case
Authors: Jokipii Terhi , Nyffeler Reto , Riederer Stéphane 
Published: October 2021

AbstractA growing body of literature has highlighted two important caveats to the credit-to-GDP gap as advocated by the Bank for International Settlements (BIS). The first relates to the approach used to normalise credit (i.e. dividing nominal credit by GDP). In this regard, critics have argued that GDP movements, that may or may not be relevant, run the risk of affecting a normalised measure of credit. The second relates to the use of the Hodrick-Prescott (HP) filter to estimate the gap’s trend component. In this regard, critics have emphasised several measurement problems associated with using the HP filter. In this paper, we assess the relevance of these critiques for Switzerland. Our findings show that despite its drawbacks, the BIS gap is a reliable measure of excess credit in Switzerland. Alternatives do not provide clear advantages, rather they are considerably more complex to estimate and come with their own set of pitfalls. For policymaking purposes, the BIS gap’s signal should be complemented with narratives based on a broader set of credit metrics to ensure that an all-encompassing risk assessment is made.
A novel signal-adaptive multi-feature extraction algorithm for arrhythmia detection
Authors: Vinutha L. B. , Ramkumar P. S. , Kunabeva Rajashekar 
Published: October 2021

Abstract
Background
The significant features like an amplitude and intervals of electrocardiograph or P-QRS-T wave represent the functionality of the heart. Accurate extraction of these features helps in capturing characteristics of the signal helpful for the detection of cardiac abnormalities. In this paper, a novel signal folding-based algorithm is proposed to obtain detailed information about the complex morphology of signal. It explores the denoising and feature extraction of the specific ECG signals.

Results
The experimental study conducted using MIT-BIH Arrhythmia database ECG records with known conditions of left bundle branch block, right bundle branch block, Wolff-Parkinson-White syndrome beats has been considered. Heart rate values for selected ECG records from MIT-BIH dataset and synthetic signals from ECG simulator yielded the same values and thus validate our approach.

Conclusion
The proposed algorithm determines the heart rate, percentage leakage around the peak and is capable of folding a signal very efficiently based on detected R peaks and period-dependent gate(window).
Effect of irisin on metabolic and platelet functions in type 2 diabetic rats: role of soluble receptor of advanced glycation end products (sRAGE)
Authors: Mansour Sherif W. , Hasan Mai M. , Salah Hossam E. , El-Deep Talal , Hussein Samia , El-Malkey Nanees F. 
Published: October 2021

Abstract
Background
Irisin is an adipomyokine with a promising potential for the treatment of metabolic disturbances and endothelial dysfunction. This study aimed to explore the effect of irisin on metabolic and platelet functions, and to explore the possible involvement of soluble receptor of advanced glycation end product (sRAGE) in the type 2 diabetes mellitus (T2DM) rat model. Thirty-three adult male albino rats were divided into three groups: normal control, vehicle-treated T2DM group, and irisin-treated T2DM. At the end of the study period, metabolic parameters, platelet count, mean platelet volume, platelet distribution width, plateletcrit, and serum sRAGE were determined.

Results
Irisin significantly improved platelet function and metabolic derangements induced by T2DM and significantly increased sRAGE. sRAGE was significantly negatively associated with platelet function parameters and some glucometabolic parameters. Additionally, mean platelet volume showed a significant predictive value for the change in serum sRAGE.

Conclusions
Irisin could have a protective role against diabetes-induced platelet dysfunction by increasing sRAGE levels, indicating the potential beneficial effects of sRAGE in the type 2 diabetic rat model.
Mpemba effect in an anisotropically driven granular gas
Authors: Biswas Apurba , Prasad V. V. , Rajesh R. 
Published: October 2021

Abstract
The Mpemba effect refers to the counterintuitive relaxation wherein a hotter system equilibrates faster than a cooler system when quenched to a cold temperature. Even though the effect has been illustrated for isotropically driven granular gases, a prototypical system far from equilibrium, its existence requires non-stationary initial states, limiting experimental realisation. In this paper, we demonstrate the existence of the Mpemba effect in anisotropically driven granular gases, even when quenched from initial states that are stationary. Our theoretical predictions, based on kinetic theory, for the regular, inverse and strong Mpemba effects agree well with results of event-driven molecular dynamics simulations of hard discs.
Orbital selective dynamics in Fe-pnictides triggered by polarized pump pulse excitations
Authors: Adhikary Ganesh , Saha Tanusree , Rebernik Ribič Primož , Stupar Matija , Ressel Barbara , Urbančič Jurij , De Ninno Giovanni , Thamizhavel A. , Maiti Kalobaran 
Published: October 2021

Abstract
Quantum materials display exotic behaviours related to the interplay between temperature-driven phase transitions. Here, we study the electron dynamics in one such material, CaFe2As2, a parent Fe-based superconductor, employing time- and angle-resolved photoemission spectroscopy. CaFe2As2 exhibits concomitant transition to spin density wave state and tetragonal to orthorhombic structure below 170 K. The Fermi surface of this material consists of three hole pockets

, β and

around the Γ-point and two electron pockets around the X-point. The hole pockets have d

xy
, d

yz
and d

zx
orbital symmetries. The β band constituted by d

xz
/d

yz
orbitals exhibits a gap across the magnetic phase transition. We discover that polarized pump pulses can induce excitations of electrons of a selected symmetry. More specifically, while s-polarized light (polarization vector perpendicular to the xz plane) excites electrons corresponding to all the three hole bands, p-polarized light excites electrons essentially from

,

bands which are responsible for magnetic order. Interestingly, within the magnetically ordered phase, the excitation due to the p-polarized pump pulses occur at a time scale of 50 fs, which is significantly faster than the excitation induced by s-polarized light (∼200 fs). These results suggest that the relaxation of different ordered phases occurs at different time scales and this method can be used to achieve selective excitations to disentangle complexity in the study of quantum materials.