bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Co-Production Strategy to Facilitate the Adoption and Implementation of Evidence-Based Colorectal Cancer Screening Interventions for Rural Health Systems: A Pilot Study
Authors: Kim Jungyoon , Estabrooks Paul , Aggarwal Alisha , McMillan Analisa , Alshehri Khalid 
Published: November 2021

Abstract
Background: Evidence-based colorectal cancer screening (CRCS) interventions exist, but have not been broadly adopted in rural primary care settings. Participatory adoption and implementation strategies may be promising in closing this gap through a clinical-academic partnership to guide rural practitioners to locate, select, and implement CRCS interventions that align with local context. We developed a prototype strategy adapted from the National Cancer Institute’s ‘Putting Public Health Evidence in Action’ curriculum in collaboration with two rural clinics to facilitate systems change related to CRCS. This paper describes the process of co-development and delivery of a systems-focused strategy to improve adoption, implementation, and sustainability of CRCS interventions. Methods: We used a bundle of implementation strategies with a core focus on academic-clinical partnership development and Plan-Do-Study-Act cycles to identify clinical partner interests/preferences on delivery methods and content needed to facilitate intervention identification and systems-change processes that improve CRCS rates. Clinic physicians and staff (n=7) at the rural clinics were asked to evaluate the approach based on overall reactions and perceptions of innovation characteristics using 5-point Likert scale. After completing the systems-change process, we conducted key-stakeholder interviews (n=5) to assess feasibility and acceptability on content/delivery format and plans for ongoing implementation of CRCS evidence-based interventions (EBIs). Results: Electronic blueprints for CRCS EBI selection and implementation (8 modules) were developed and followed by an online forum/live-streaming conference to allow for CRCS tailoring. The two clinics used different learning approaches: one completed the modules together while the other completed the modules separately to cover material before a group video conference. Across all modules, participants in both clinics reported positive reactions toward the systems-change modules. Both clinics reported improvements in how they perceived the characteristics of the modules and the participatory approach to tailor selected CRCS EBIs. Through the process both clinics developed a specific EBI implementation plan. Interview participants reported that the approach was feasible and acceptable, and provided suggestions for further improvements on content, delivery, and format of the approach.Conclusions: The bundle of implementation strategies used were feasible and acceptable in rural primary care practices to facilitate the use of evidence-based approaches to improve CRCS.
In situ new variations in Puccinia triticina causing leaf rust on wheat
Authors: Kumar Subodh , Bhardwaj Subhash Chander , Gangwar Om Prakash , Prasad Pramod , Lata Charu , Adhikari Sneha 
Published: November 2021

Abstract
During the periodic purity checks of pathotypes 107-1(45R35=JCGPL) and 20(5R27=SGQPL) of Puccinia triticina in national repository at Shimla, India, mixtures of infection types were observed on the differential Lr3 and Lr15 , respectively. Single pustule isolations and further pure cultures in both the cases yielded new pathotypes designated as 57(45R39= KGTPL) and 20-2(57R27= SHKPL). Pathotype 57 was one step gain in virulence on Lr3 in 107-1 whereas 20-2 on Lr15 in mother culture of pathotype 20. The difference of virulence on one gene to each mother culture and their non occurrence in the field samples is indicative of mutation for virulence in situ . To ascertain the novelty of new pathotypes, detailed study on differentials, avirulence/virulence structure, DNA polymorphism using SSR markers, and other related information is presented in this publication. The new cultures are being maintained as PrtI 57 and PrtI 20-2 in the repository.
High-speed Railways and Environmental Pollution: The Mediating Effect of Environmental Regulations and Moderating Effect of Officials' Political Promotion Incentives
Authors: Li Liping , Wang Yuandi , Chen Qisheng , Wu Jiang , Jia Ximeng 
Published: November 2021

Abstract
This study examines the relationship between high-speed railways (HSRs) and environmental pollution by focusing on the mediating role of environmental regulations and the moderating role of officials’ political promotion incentives. Based on a sample of 113 prefecture-level cities, with balanced panel data in China from 2009 to 2017, using the difference-in-differences (DID) model, the results show that HSRs can reduce environmental pollution via the mediating effect of environmental regulations. Additionally, high officials’ political promotion incentives can strengthen this mediating effect. A propensity score matching with difference-in-differences (PSM-DID) model is used to solve endogenous problems, and a placebo test and a parallel trend test indicate that these results are robust. This study encourages the government to rationally promote the construction of high-speed railways and expand the social advantages of high-speed railways to improve environmental regulations and reduce environmental pollution.
The Risk of Peripheral Arterial Disease in Long-Term Uterine Cancer Survivors: A Population-BasedStudy
Authors: Chen Min-Chi , Chang Jung-Jung , Lee Kuan-Der , Chen Miao-Fen , Wang Ting-Yao , Huang Cih-En , Chen Chao-Yu 
Published: November 2021

Abstract
Background: The risk of peripheral arterial disease (PAD) in long-term uterine cancer (UC) survivors remains unclear, especially in Asian patients, who are younger at the diagnosis of UC than their Western counterparts. Methods: UC survivors, defined as those who survived for longer than 5 years after the diagnosis, were identified and matched at a 1:4 ratio with normal controls. Stratified Cox models were used to assess the risk of PAD. Results: From 2000 to 2005, 1,889 UC survivors who received surgery alone or surgery combined with radiotherapy (RT) were classified into young (onset age <50 years, n=894) and older (onset age ≥50 years, n=995) groups. While compared with normal controls, the young patients with diabetes, hypertension, and receiving hormone replacement therapy (HRT) were more likely to develop PAD. In contrast, the risk of PAD was associated with adjuvant RT, obesity, hypertension, and HRT in the older group. Among the UC survivors, those who were diagnosed at an advanced age (>65 years, aHR³2.48, P£0.011), had hypertension (aHR=2.18, P=0.008) or received HRT (aHR=3.52, P=0.020) were at higher risk of PAD. Conclusion: In this nationwide study, we found that the risk factors associated with PAD were similar in both cohorts except for adjuvant RT that was negligible in the young age group, but positive in the older group. Among the survivors, hypertension, advanced age, and HRT were more hazardous than RT. Secondary prevention should include PAD as a late complication in UC survivorship programs.
Updated nationally determined contributions collectively raise ambition levels but need strengthening further to keep Paris goals within reach
Authors: Elzen Michel den , Dafnomilis Ioannis , Forsell Nicklas , Fragkos Panagiotis , Fragkiadakis Kostas , Höhne Niklas , Kuramochi Takeshi , Nascimento Leonardo , Roelfsema Mark , Soest Heleen van , Sperling Frank 
Published: November 2021

Abstract
By September 2021, 120 countries had submitted new or updated Nationally Determined Contributions (NDCs) to the UNFCCC in the context of the Paris Agreement. This study analyses the greenhouse gas (GHG) emissions and macroeconomic impacts of the new NDCs. The total impact of the updated NDCs of these countries on global emission levels by 2030 is an additional reduction of about 3.7 GtCO2e, compared to the previously submitted NDCs. This increases to about 4.1 GtCO2e, if also the lower projected emissions of the other countries are included. However, this total reduction needs to be four times greater to be consistent with keeping global temperature increase to well below 2 °C, and even eight times greater for 1.5 °C. Seven G20 economies have pledged stronger emission reduction targets for 2030 in their updated NDCs, leading to additional aggregated GHG emission reductions of about 3.1 GtCO2e, compared to those in the previous NDCs. The socio-economic impacts of the updated NDCs are limited in major economies, while structural shifts occur away from fossil fuel supply sectors and towards renewable electricity. However, two G20 economies have submitted new targets that will lead to an increase in emissions of about 0.3 GtCO2e, compared to their previous NDCs. The updated NDCs of non-G20 economies contain further net reductions. We conclude that countries should strongly increase the ambition levels of their updated NDC submissions to keep the climate goals of the Paris Agreement within reach.
The Effect of TSH-Suppressive Dose of Levothyroxine On Skeletal Muscle In Ovariectomized Rats
Authors: Kim Jeong Hun , Kim Ji Min , Lee Byung-Joo , Kim In-Joo , Pak Kyoungjune , Kim Keunyoung 
Published: November 2021

Abstract
Hyperthyroidism is often observed in postmenopausal women due to conditions such as thyroiditis and toxic nodular goiter, Grave’s disease or thyroid stimulating hormone suppressive therapy for treating differentiated thyroid carcinoma (DTC). However, the effect of such hormonal changes on skeletal muscles in females remain unclear. Therefore, this study aimed to observe the effects of hyperthyroidism on the skeletal muscle of ovariectomized rats. We randomly divided female Sprague-Dawley rats into sham-operated (Sham), ovariectomized (OVX), and levothyroxine-treated ovariectomized groups (OVX+LT4). Levothyroxine was administered intraperitoneally at 0.3 mg/kg, daily for six weeks. Protein synthesis was increased after ovariectomy whereas protein synthesis was suppressed and protein degradation was increased in response to levothyroxine treatment. However, there was no difference in lean mass between the two groups. Collagen I levels were similar between the Sham and OVX groups, but were significantly decreased in the OVX+LT4 group. The mRNA levels of matrix metalloproteinase (MMP) ‐2 and ‐9 were similar between the Sham and OVX groups but were upregulated in the OVX+LT4 group. After ovariectomy, mitochondrial biogenesis and dynamics were changed; these changes were exacerbated in hyperthyroidism. Our findings indicate that in postmenopausal rats with hyperthyroidism, the progression of muscle weakness occurs through impaired regulation of signaling pathways related to extracellular matrix homeostasis, protein turnover, and mitochondrial quality.
Heterogeneous Fates of Simultaneously-Born Neurons During Early Corticogenesis
Authors: Magrinelli Elia , Klingler Esther , Baumann Natalia , Wagener Robin Jan , Glangetas Christelle , Bellone Camilla , Jabaudon Denis 
Published: November 2021

Abstract
Neocortical excitatory neurons belong to diverse cell types, which can be distinguished by their dates of birth, laminar location, connectivity and molecular identities. During embryogenesis, apical progenitors (APs) located in the ventricular zone first give birth to deep-layer neurons, and next to superficial-layer neurons. While the overall sequential construction of neocortical layers is well-established, whether multiple neuron types are produced by APs at single time points of corticogenesis is unknown. To address this question, here we used FlashTag to fate-map simultaneously-born (i.e. isochronic) cohorts of neurons at successive stages of corticogenesis. We reveal that early in corticogenesis, isochronic neurons differentiate into heterogeneous laminar, hodological and molecular cell types. Later on, instead, simultaneously-born neurons have more homogeneous fates. Using single-cell gene expression analyses, we identify an early postmitotic surge in the molecular heterogeneity of nascent neurons during which some early-born neurons initiate and partially execute late-born neuron transcriptional programs. Together, these findings suggest that as corticogenesis unfolds, mechanisms allowing increased homogeneity in neuronal output are progressively implemented, resulting in progressively more predictable neuronal identities.
Mediastinal/hilar lymphadenopathy: A possibly overlooked variable in the classification of lung nodules
Authors: Liu Fenghui , Dai Liping , Wang Yulin , Liu Man , Wang Meng , Zhou Zhigang , Qi Yu , Chen Ruiying , Sun Ting , Ma Xiaohua , Sun Xiaoxu , Zhao Chunling , OuYang songyun , Fan Qingxia 
Published: November 2021

Abstract
Background

Clinical prediction models to classify lung nodules often exclude patients with mediastinal/hilar lymphadenopathy, although the presence of mediastinal/hilar lymphadenopathy does not always indicate malignancy. Herein, we developed and validated a multimodal prediction model for lung nodules in which patients with mediastinal/hilar lymphadenopathy were included.
Methods

A total of 359 patients with pulmonary nodules were considered for enrollment in the study. We developed and validated a logistic regression model including patients with mediastinal/hilar lymphadenopathy. Discrimination of the model was assessed by area under the operating curve. Goodness of fit was performed via the Hosmer-Lemeshow test, and a nomogram of the logistic regression model was drawn.
Results

There were 311 cases included in the final analysis. A logistic regression model was developed and validated. There were nine independent variables included in the model. The AUC of the training and validation sets was 0.93 (95% CI, 0.90–0.97) and 0.91 (95% CI, 0.85–0.98), respectively. In the validation set with or without mediastinal/hilar lymphadenopathy, the AUC was 0.95 (95% CI, 0.90–0.99) and 0.91 (95%CI, 0.87–0.95), respectively. The Hosmer-Lemeshow goodness-of-fit statistic was 0.22. A nomogram was drawn to visualize the model.
Conclusions

We developed and validated a multimodal risk prediction model for lung nodules with excellent discrimination and calibration, regardless of the inclusion of mediastinal/hilar lymphadenopathy. This broadens the application of lung nodule prediction models. Furthermore, the presence of mediastinal/hilar lymphadenopathy added value for predicting lung nodule malignancy, highlighting the importance of this variable in clinical practice.
The role of AIHIP in Preoperative Planning of Total Hip Arthroplasty to Different Surgeons.
Authors: Li Wenao , Yao Xiaowei , Zhang Bingshi , Ding Xuzhuang , Huo Jia , Liu Sikai , Han Yongtai 
Published: November 2021

Abstract
BackgroundPreoperative planning with computed tomography (CT)-based three-dimensional templating has been achieved more precise placement of hip components. This study investigated the value of the software for preoperative planning (artificial intelligence hip system, AIHIP) in primary total hip arthroplasty (THA) for surgeons with different experience levels.MethodsWe performed a retrospective study of 240 hips in 240 patients who underwent cementless primary THA. The patients were divided into four groups: A1) senior surgeon without AIHIP, A2) senior surgeon with AIHIP, B1) junior surgeon without AIHIP, and B2) junior surgeon with AIHIP. All preoperative planning evaluations were completed using the AIHIP software. We analysed the accuracy of stem size prediction and cup size prediction, the absolute value of postoperative discrepancy in leg length, discrepancy of neck-shaft angle and femoral offset between the healthy side and the affected side from the anteroposterior radiographic view of the hip, intraoperative and postoperative complications, operative times, the reduction in the haemoglobin (Hb) level during the first 24 hours and the number of intraoperative radiations.ResultsThe sizes of 95% were accurately estimated to be within one stem size, and 97% of the cup size estimates were accurate to within one cup size in group A2. A total of 87% were accurately estimated to be within one stem size, and 85% were accurate to within one cup size in group B2. There was a significant difference in radiological indicators (P<0.050), postoperative complications (overall P=0.035), operation duration (P<0.001), decrease in Hb per 24 hours (P=0.046) and intraoperative radiation frequency (P<0.050) among the patients in group B. There was also a significant difference in postoperative complications (overall P=0.01) between groups A1 and B1.ConclusionOur results suggest that the AIHIP is a favourable tool for young surgeons, and the accuracy is good.
Factors associated with different patterns of weight change after bariatric surgery: A longitudinal study
Authors: Carrillo Diana Cristina Henao , Gómez Ana María , Muñoz Oscar , Rubio Claudia , Rodríguez Natalia , Ursida Valentina , Forero Ana , Pinzón Fabio , Mikler Rami 
Published: November 2021

Abstract
Background
Bariatric surgery is the most effective treatment for obesity. During long-term follow-up, weight loss (WL) is variable between subjects. The aim of this study is to assess the change in percentage of total weight loss (%TWL) and excess weight loss (%EWL) and to describe the factors associated with greater or lesser WL over time.
Methods
Longitudinal study including patients treated with laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (LSG) and followed at Hospital Universitario San Ignacio, Bogotá (Colombia). Baseline data was recorded before surgery. Follow-up was performed at 3 (n=192), 6 (n=190), 9 (n=188), 12 (n=186), 24 (n=99) and 36 (n=30) months. Generalized Estimating Equation (GEE) analysis was used to assess the change in %TWL and %EWL over time.
Results
196 patients were included (82.4% female, BMI 41.3±5.2 kg/m2). The tendency to increase on %TWL (31.6±6.6) and %EWL (80.2 RIQ 70.7-97.3) was evident in the first year, stabilizing after that. Nutritionist follow-up, baseline BMI>40 kg/m2 and WL≥10kg before surgery were associated with an average higher increase of %TWL (2.39% p=0.014, 0.41% p<0.001 and 0.37% p=0.003, respectively). Subjects who performed physical activity >30 minutes/day after surgery reduced %TWL in 0.74% (p=0.009). Similar findings were described on %EWL.
Conclusion
Follow-up during the first year after bariatric surgery is critical to achieving %TWL and %EWL goals. This study suggests that modifiable factors such as nutritional follow-up, WL before surgery and time of physical activity are associated with a significant change in %TWL and %EWL during follow-up by a multidisciplinary team.
Balanced Reciprocal Translocation t(17;22)(p11.2;q11.2) and 10q23.31 Microduplication in a Infertility Male Suffering from Teratospermia
Authors: Huang Shan , Wu Huiling , Qi Yunwei , Wei Liqiang , Lv Xiaodan , He Yu 
Published: November 2021

Abstract
We describe the first case of two chromosomal abnormalities, balanced reciprocal translocation t(17;22)(p11.2;q11.2) and a microduplication in the region 10q23.31, in an infertility man suffering from teratospermia. Several genes located on the translocation breakpoints or the region of duplication show rich expression in the tissue of testis. They have been reported to be associated with developmental disorder and retardation, which might also be the risk factors affecting in spermatogonial differentiation and spermatogenesis. More studies should be carried out for identifification of new genes associated with semen quality. Our case might support the opinion that haploinsufficiency of the testis-expressed gene could be the cause of sperm immotility and abnormal sperm morphology. The two chromosomal abnormalities that carry additional reproductive risks, is apparently harmful with regard to the male infertility, and could contribute to the genomic instability resulting in disease.
Identification of Genetic Loci for Sugarcane Leaf Angle at Different Developmental Stages by Genome-Wide Association Study
Authors: Chen Xinglong , Huang Zhenghui , Zhang Xiangbo , Feng Xiaomin , Xie Jinfang , Wu Bin , Luo Yiji , Zhu Mingfeng , Qi Yongwen 
Published: November 2021

Abstract
Background

Sugarcane (Saccharum spp.) is an efficient crop mainly used for sugar and bioethanol production. High yield and high sucrose of sugarcane is always the fundamental demands in sugarcane growth worldwide. Leaf angle and size of sugarcane can be attributed to planting density, which was associated with yield. In this study, we performed Genome-Wide Association Studies (GWAS) in a panel of 216 sugarcane core parents and their derived lines (natural population) to determine the genetic basis of leaf angle and key candidate genes at seedling, elongation and maturity stage.
Results

A total of 288 significant associated loci of sugarcane leaf angle at different developmental Stages were identified by GWAS. Among them, one key locus and eleven loci was identified in all three stages and two stages, respectively. Overall, 4089 genes were located in the confidence interval of significant loci, among which 3892 genes were functionally annotated. Finally, thirteen core parents and their derivatives tagged with SNPs were selected for Marker-assisted selection (MAS).
Conclusion

These candidate genes are mainly related to MYB transcription factors, auxin response factors, serine/threonine-protein kinases, etc. The are directly or indirectly associated with leaf angle in sugarcane. This research provided a large number of novel genetic resources for the improvement of leaf angles and simultaneously to high yield and high bioethanol production.
Spatio-Temporal Patterns of Fitness Behavior In Beijing Based on Social Media Data
Authors: Bin Tian , Bin Meng , Guoqing Zhi , Zhenyu Qi , Siyu Chen , Jian Liu 
Published: November 2021

Abstract
Using social media data, this paper employs FastAI, Latent Dirichlet Allocation (LDA) and other text mining techniques coupled with GIS spatial analysis methods to study temporal and spatial patterns of fitness behavior of residents in Beijing, China, from the perspective of residents’ daily behavior. Using LDA theme model technology, it is found that fitness activities can be divided into four types: running-based fitness; riding-based fitness; fitness in sports venue; and fitness under professional guidance. Emotional analysis revealed that, residents can get a better fitness experience in sports venues. There are also obvious differences in the spatio-temporal distribution of the different fitness behaviors. Fitness behavior of Beijing residents has a multi-center spatial distribution pattern, with a wide coverage in northern city areas but obvious aggregation areas in southern city areas. In terms of temporal patterns, the residents' fitness frequency shows an obvious periodic distribution (weekly and 24 hours). And there are obvious differences in the time distribution of fitness behaviors for each theme. Additionally, based on the attribution analysis of a geodetector, it is found that the spatial distribution of fitness behavior of residents is mainly affected by factors such as catering services, education and culture, companies and public facilities.
In Vitro Sterilization Procedures For Micropropagating Silphium Integrifolium Michx.
Authors: Chen Yuqi , Cohen Jerry , Smith Kevin , Pincelli-Souza Renata 
Published: November 2021

Abstract
Perennial crops are constantly exposed to fungi and bacteria in their environment, and thus explants from field-grown plants are difficult to disinfect for micropropagation because of both endophytic and epiphytic microbes. Field grown S. integrifolium plants were potted and grown in the greenhouse for five weeks; new stems and anthers along with seeds were tested for in vitro sterilization. We report successful sterilization protocols that involved disinfecting seeds with isothiazolone biocides (PPM) and NaClO and sterilizing stems and anthers through vacuum infiltration of PPM. The establishing of the protocols is useful for subsequent micropropagation and would in this way facilitate Silphium breeding and domestication processes.