bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stigma and Adults with Tourette’s Syndrome: “Never Laugh at Other People’s Disabilities, Unless they have Tourette’s—Because How Can You Not?”
Authors: Malli Melina Aikaterini , Forrester-Jones Rachel 
Published: December 2021

AbstractTourette’s syndrome (TS) is a condition that has been stigmatised and mocked in contemporary society, yet little is known about the subjective experience of those directly affected by it. Guided by Public and Patient Involvement (PPI) a mixed method design was used for this study to explore the experience of stigma in adults living with TS in the UK. A total of one hundred and ninety-nine adults participated in a cross-sectional online survey using an adapted version of the Discrimination and Stigma Scale (DISC-12) and the Perceived Quality of Life (PQoL) scale, twenty of whom were also interviewed using a semi-structured interview schedule. Quantitative findings indicated that participants experienced discrimination in numerous life domains; most prominently in education (75.4%), social life (71.4%), public transport (60.8%) and employment (54.3.%). The PQoL of adults with Tourette’s was found to be negatively correlated with bothEnactedandAnticipated Discriminationfrom the DISC-12 scale. Qualitative findings illustrated the pervasive nature of TS stigma, which expanded beyond micro-interactions, and which could be observed at a structural level. The peculiar impact of disparagement humour in the construction and promulgation of “othering” individuals with TS was also highlighted. Concealment and self-stigma were mechanisms commonly utilised by individuals to manage their “spoiled identity”, inhibiting active and collective responses to stigmatisation. The study highlights how TS stigma acts as a barrier to social and economic participation for adults with the condition and helps identify factors that need to be considered when developing anti-stigma strategies.
Educational Attainment Past the Traditional Age of Completion for Two Cohorts of US Adults: Inequalities by Gender and Race/Ethnicity
Authors: Cohen Alison K. , Ryan Sarah , Smith Louisa H. , Ream Robert K. , Glymour M. Maria , Lopez Andrea , Yen Irene H. 
Published: December 2021

AbstractThe vast majority of studies investigating participation in, persistence through, and consequences of postsecondary education focus on educational attainment status among the so-called traditional population of collegegoers between the ages of 18 and 24. This narrow focus leaves largely invisible the role that an expanding set of educational trajectories throughout adulthood plays in shaping social stratification. Using 35-plus and 20 years of follow-up data from the US National Longitudinal Survey of Youth (NLSY)’s 1979 and 1997 cohorts, we find that a substantial share within each cohort is attaining education well into adulthood, and that these trajectories are patterned according to key social and demographic characteristics. In both cohorts, racial/ethnic differences in educational attainment grew over time and, for those attaining the same degree, members of historically disadvantaged groups did so at an older age. Cohort differences in trajectories emerged, however, when considering the intersection of race/ethnicity and socialized gender. Through careful descriptive analysis of two generational cohorts, our study makes clear the role of educational trajectories in the process of cumulative (dis)advantage across the life course, as well as across generations.
Femoral Neck Osteotomy: A Salvage Procedure for Unstable and Locked Acetabulum Fractures in Selected Frail Patients
Authors: Cibura Charlotte , Yilmaz Emre , Straeter Dina , Schildhauer Thomas A. , Kruppa Christiane 
Published: December 2021

Abstract
Introduction
Purpose of the study is to present and discuss the femoral neck osteotomy as a salvage procedure for unstable, locked geriatric acetabular fractures in selected frail patients. When disadvantages and possible risks of other treatments exceed the benefits, this method may relieve pain and allow for early wheelchair mobilization in frail patients with limited mobility.

Materials and Methods
We report nine patients from 2008 to 2020, which were treated with an osteotomy of the femoral neck for an unstable acetabular fracture. Indications, ASA-Score, Frailty Index, operative procedure, length of hospital stay, complications and outcomes will be discussed.

Results
Patient’s age averaged 86 years (range 81–92). Acetabular fractures were classified as six both column fractures, two anterior column posterior hemitransversal fractures and one destruction of the acetabulum by multiple metastases. Fracture dislocation with medialization plus locking of the femoral head and a superomedial dome impaction were present in all patients. All patients were classified as ASA III/ IV and the average value on the CSHA Frailty index was 7 (range 6–7). The operation time averaged 52 min (range 34–62). Immediate wheelchair mobilization in seven out of nine patients was started postoperatively.

Conclusion
The osteotomy of the femoral neck may be discussed as a salvage procedure in low functional demanding, multimorbid, frail geriatric patients with unstable acetabular fractures and impairment of mobilisation due to a locked femoral head. The procedure has the advantages of a short operation time and immediate mobilization of the patients. However, this procedure only applies as a salvage solution in selected individual cases.
Digital Entrepreneurship
Authors: Morabito Vincenzo 
Published: December 2021

A comprehensive guide to digital entrepreneurship, bridging academic research and industry practice. Morabito provides a strategic overview of the main challenges and trends related to digital entrepreneurship, structured in three parts. Part I focuses on strategy and management issues, guiding readers through the theory and practice of building, implementing and growing new digital ventures and outlining the skills that are necessary for digital entrepreneurs to succeed and lead. Part II focuses on digital business systems, describing the main technological aspects that support and comprise the core infrastructure for digital entrepreneurship, including social media and the Internet of Things. Finally, Part III provides analyses of three core industries in which digital ventures are particularly important: fintech, manufacturing and fashion. Digital Entrepreneurship will appeal to students and researchers in the areas of digital strategy/innovation and information systems management. It will also be of interest to practitioners looking to develop or innovate digital ventures.
An -valued index of symmetry-protected topological phases with on-site finite group symmetry for two-dimensional quantum spin systems
Authors: Ogata Yoshiko 
Published: December 2021

AbstractWe consider symmetry-protected topological phases with on-site finite groupGsymmetry$\beta $for two-dimensional quantum spin systems. We show that they have$H^{3}(G,{\mathbb T})$-valued invariant.
Quality and validity of diet quality indices for use in Australian contexts: a systematic review
Authors: Tan Mui Siew , Cheung Ho Ching , McAuley Erynn , Ross Lynda J. , MacLaughlin Helen L. 
Published: December 2021

AbstractDiet quality indices (DQIs) are tools used to evaluate the overall diet quality against dietary guidelines or known healthy dietary patterns. This review aimed to evaluate DQIs and their validation processes to facilitate decision making in the selection of appropriate DQI for use in Australian contexts. A search of CINAHL, PubMed and Scopus electronic databases was conducted for studies published between January 2010 and May 2020, which validated a DQI, measuring > 1 dimension of diet quality (adequacy, balance, moderation, variety) and was applicable to the Australian context. Data on constructs, scoring, weighting and validation methods (construct validity, criterion validity, reliability and reproducibility) were extracted and summarised. The quality of the validation process was evaluated using COnsensus-based Standards for the selection of health Measurement INstruments Risk of Bias and Joanna Briggs Appraisal checklists. The review identified twenty-seven indices measuring adherence to: national dietary guidelines (n 13), Mediterranean Diet (n 8) and specific population recommendations and chronic disease risk (n 6). Extensiveness of the validation process varied widely across and within categories. Construct validity was the most strongly assessed measurement property, while evaluation of measurement error was frequently inadequate. DQIs should capture multiple dimensions of diet quality, possess a reliable scoring system and demonstrate adequate evidence in their validation framework to support use in the intended context. Researchers need to understand the limitations of newly developed DQIs and interpret results in view of the validation evidence. Future research on DQIs is indicated to improve evaluation of measurement error, reproducibility and reliability.
Application of rigid bronchoscopy for emergent removal of tracheobronchial foreign body in paediatric cases: a learning curve study
Authors: Bin X , Liu L , Fang Q , Tan SH , Tang AZ 
Published: December 2021

AbstractObjectivesTo explore the factors associated with the operative duration for paediatric tracheobronchial foreign body removal by rigid bronchoscopy, and to analyse the learning curve for mastery of the rigid bronchoscopy skill.MethodsA retrospective study was performed of paediatric cases of tracheobronchial foreign body removal by rigid bronchoscopy in our department from January 2007 to July 2019. Multivariate Cox regression analysis was used to analyse the factors associated with the operative duration. In addition, the learning curves for two doctors were evaluated by curve-fitting regression analysis.ResultsA total of 410 paediatric cases of tracheobronchial foreign body removal by rigid bronchoscopy were evaluated. The operative duration was significantly influenced by the skill of the doctor. The learning curves for both doctor A and doctor B demonstrated two typical phases: an initially rapidly changing learning phase followed by a steady consolidation phase.ConclusionThe operative duration for paediatric tracheobronchial foreign body removal by rigid bronchoscopy was associated with the skill of the doctor. In order to fully master the rigid bronchoscopy technique, doctors should perform a minimum number of procedures to pass the learning phase and reach the consolidation phase.
Bacteriophages and their microbial hosts in terrestrial biotopes of Antarctica
Authors: Holovan Viktoriia , Andriichuk Olena , Budzanivska Irena , Zelena Pavlina , Kondratiuk Tetiana , Shevchenko Oleksiy 
Published: December 2021

AbstractVirus diversity in Antarctic biotopes remains understudied. Here, we describe bacteriophages isolated from terrestrial environments, provide data on their natural bacterial hosts and study phage-host systems. Six bacterial isolates (FCKU 539, FCKU 533, FCKU 534, FCKU 538, FCKU 542 and FCKU 540) were recovered and characterized. Isolated bacteria belonged to Pseudomonas genus (Pseudomonas sp., Pseudomonas fluorescens, Pseudomonas putida) with optimal cultivation temperatures of 16–28°C. These bacteria and previously described Bacillus subtilis FCKU 537 were used for analysing virus-host interactions. Six lytic phages were isolated and named P. fluorescens Antarctic virus 1 (PFAV1), P. fluorescens Antarctic virus 2 (PFAV2), P. fluorescens Antarctic virus 3 (PFAV3), P. putida Antarctic virus 4 (PPAV4), Pseudomonas sp. Antarctic virus 5 (PSAV5) and B. subtilis Antarctic virus 6 (BSAV6) in relation to their natural hosts. According to electron microscopy data, these phages belonged to Caudovirales order. Cross-inoculation demonstrated high specificity of all Antarctic phages, which infected only their initial hosts at moderate temperatures. PFAV2 and PFAV3 phages also infected laboratory Pseudomonas savastanoi and P. fluorescens isolates. This paper adds new data on the occurrence and diversity of viruses and their respective bacterial hosts in soil biotopes of Antarctica.
Serotiny in Melocactus matanzanus (Cactaceae) and role of cephalium in dispersal of seeds after the individual's death
Authors: Barrios Duniel , Toledo Sandy , Sánchez Jorge A. , González-Torres Luis R. 
Published: December 2021

AbstractSerotiny is a strategy in which the retention of mature seeds in parent structures allows plants to cope with environmental variability like heat, drought or fire. Although this phenomenon might be common in Cactaceae, and particularly in Melocactus, it has generally been scarcely addressed. The main goal of our work is to investigate if there are seeds hidden in the cephalium of Melocactus matanzanus and if there are, determine whether or not these seeds maintain their viability. We also discuss some advantages the cephalium may offer as diaspore after the death of individuals. Cephalia collected from dead individuals were divided into four slices and their seeds counted; we also assessed the viability and photoblastic response of the seeds by using growth chambers at 25/30°C, and by a cut test on the seeds that did not germinate. Our results showed retention of viable seeds of different ages in all slices of the cephalium. Seeds were photoblastic positive with germination between 11–22% and viability above 50% in the portion of the lots that did not germinate.
Can hemp hurd or paper mulch and biochar application improve weed management in matted-row strawberry production systems?
Authors: Gramig Greta G. , Hogstad Samantha K. , Carr Patrick M. 
Published: December 2021

AbstractDuring 2015 and 2016, studies were conducted at Absaraka and Dickinson, North Dakota to evaluate the impacts of hemp (applied at 1156 m3 ha−1) and commercial paper mulch, as well as soil-applied biochar (applied at 11.25 m3 ha−1), on weed suppression and strawberry growth during the establishment year, and on weed suppression and strawberry yield during the production year, in a matted row production (MRP) system. During 2015, biochar influenced dry weed biomass only within the hemp mulch, with slightly more weed biomass associated with biochar application compared to zero biochar (3.1 vs 0.4 g m−2), suggesting that biochar may have increased weed germination and/or emergence from beneath hemp mulch. Biochar application also slightly increased soil pH, from 6.9 in non-amended soil to 7.0 in amended soil. Strawberry runner number during 2015 was greater in association with hemp or paper mulch compared to zero mulch (4.5 and 4.9 vs 2.4 runners plant −1, respectively). This result mirrored a similar differential in per berry mass across sites (7.6 and 7.4 vs 6.2 g berry −1 for hemp mulch, paper mulch and zero mulch, respectively). These results may be related to hemp and paper mulch reducing maximum soil temperatures during summer 2015. During the establishment year, both hemp and paper mulch suppressed weeds well compared to zero mulch, although at Absaraka hemp mulch provided slightly better weed suppression than paper mulch. During the production year, both mulches continued to suppress weeds compared to zero mulch at Dickinson. However, at Absaraka, only hemp mulch provided weed suppression compared to zero mulch, possibly because of faster paper degradation caused by greater numbers of large precipitation events and greater relative humidity at Absaraka compared to Dickinson. Weeds were removed from plots during 2015 to allow separation of weed suppression from other possible mulch impacts; therefore, yield data do not reveal striking differences among mulch treatments. Because previous research has demonstrated the impact of weed management during the establishment of strawberries in a matted row system, we concluded that hemp mulch may provide more durable weed suppression compared to paper mulch, which would increase strawberry yield protection in an MRP system. Material cost may be an issue for implementing hemp mulch, as hemp hurd cost was 25 times paper mulch at the application rates used in this study. However, hemp mulch could still be a beneficial option, especially for organic strawberry growers desiring a renewable and environmentally sound replacement for plastic mulch who are able to find affordable local sources of this material.
The Response of Precipitation Extremes to the Twentieth‐ and Twenty‐First‐Century Global Temperature Change in a Comprehensive Suite of CESM1 Large Ensemble Simulation: Revisiting the Role of Forcing Agents Vs. the Role of Forcing Magnitudes
Authors: Xu Yangyang , Lin Lei , Diao Chenrui , Wang Zhili , Bates Susan , Arblaster Julie 
Published: December 2021

AbstractThe response of precipitation extremes (PEs) to global warming is found to be nonlinear in Community Earth System Model version 1 (CESM1) and other global climate models (Pendergrass et al., 2019), which led to the concern that it is not accurate to approximate the response of PE to a single forcing as the difference between simulations with all forcing agents and those that exclude one specific forcing. This calls into question previous model‐based results that the sensitivity of PE with warming due to aerosol forcing is significantly larger than that due to greenhouse gases (GHGs). We reevaluate the PE sensitivity to GHGs and aerosols using available CESM1 ensemble simulations. We show that although the PE response to warming is nonlinear in CESM1, especially for the high warming projected in the twenty‐first‐century, PE sensitivity to aerosols is still significantly stronger than that due to GHGs when the comparison is made within similar warming regimes to avoid the bias induced by the nonlinear behavior. But the difference is smaller than previously estimated. We also conclude that the additivity assumption is largely valid to isolate the PE response due to aerosol forcing from the paired simulations including the “all forcing” experiment when the warming regime is small (e.g., 1°C–2°C in the next few decades when aerosol forcing is projected to decline and becomes a major source of uncertainty for model projection).
Duration and Intensity of End‐Permian Marine Anoxia
Authors: Pimentel‐Galvan Michael , Lau Kimberly V. , Maher Katharine , Mukerji Tapan , Lehrmann Daniel J. , Altiner Demir , Payne Jonathan L. 
Published: December 2021

AbstractOcean anoxia was an important kill mechanism in the end‐Permian mass extinction and uranium isotope data are among the most powerful tools for quantifying the global extent and duration of ocean deoxygenation due to the dependence of uranium isotope fractionation on bottom‐water redox conditions. Although coherent stratigraphic variation in uranium isotope ratios (δ238U) and uranium concentrations ([U]) indicative of prolonged deoxygenation beginning coincident with the extinction is well established, the precise extent of anoxia and associated uncertainty have yet to be quantified. Uncertainty arises from both noise in the data and imprecise knowledge of key parameters within the uranium cycle. In this study, we use the Monte Carlo method to explore a range of scenarios and their implications for the uranium cycle across the Permian‐Triassic boundary and through the first 1.7 million years of the Triassic. We then compare model predictions against measured data using principal component analysis to identify model runs and associated parameter values most compatible with trends in the observed data. The best‐fitting models indicate a pronounced increase in the extent of seafloor anoxia across the Permian/Triassic transition, reaching 18% of the seafloor (95% CI: [11%, 47%]), lasting anywhere from 20 kyr to 1.2 Myr. There is an inverse relationship between the extent and duration of anoxia in the set of best‐fitting models. This initial pulse of pronounced anoxia is followed by a prolonged aftermath, which continues through the remainder of the study interval, of less extensive, yet still expanded, anoxia covering 7.8% of the seafloor (95% CI: [1.6%, 48.9%]). Both expanded and protracted anoxia are required to fit existing data, with no indication of full re‐oxygenation during the study interval.
Thermal History of Lithosphere Formed Beneath Fast Spreading Ridges: Constraints From the Mantle Transition Zone of the East Pacific Rise at Hess Deep and Oman Drilling Project, Wadi Zeeb, Samail Ophiolite
Authors: Grambling Nadine L. , Dygert Nicholas , Boring Beau , Jean Marlon M. , Kelemen Peter B. 
Published: December 2021

AbstractWe investigate the cooling histories of peridotites and gabbros from localities that expose oceanic lithosphere formed beneath two fast seafloor spreading centers: Hess Deep as recovered from IODP Expedition 345 and ODP Leg 147, and the Oman Ophiolite as sampled by the Oman Drilling Project, ICDP Expedition 5057 (OmanDP). At these locations, relict crust‐mantle transition zones are directly sampled, enabling characterization of the thermal history of the crust‐mantle transition, and by inference, the depth extent of hydrothermal circulation beneath spreading centers. We measured major and trace element abundances in crustal gabbros and mantle peridotites from Hess Deep and OmanDP, and applied major and trace element‐based thermometers. Geospeedometric interpretation of the temperatures suggests similar cooling histories at both locations; cooling rates ranged from 0.02 to 2.6 °C/y from peak temperatures up to 1,350°C. The rates are consistent on either side of the paleo‐Moho (i.e., in the crust and mantle). Models for conductive cooling of the lower oceanic crust predict rates more than two orders of magnitude slower at the crust‐mantle transition zone, while thermal models that invoke deep and efficient hydrothermal circulation throughout the entire crustal section predict rates consistent with our observations. We infer that hydrothermal cooling extended to or near the petrologic Moho beneath the East Pacific Rise and the OmanDP paleo‐spreading center, consistent with the Sheeted Sills model for crustal accretion. Comparison with previously published rates recalculated using the methods we employed suggests the oceanic lower crust is cooled hydrothermally in some places and by conduction at others.
Senescent tumor cells: an overlooked adversary in the battle against cancer
Authors: Park Soon Sang , Choi Yong Won , Kim Jang-Hee , Kim Hong Seok , Park Tae Jun 
Published: December 2021

AbstractSenescent cells in cancer tissue, including senescent fibroblasts and macrophages, have been reported to increase the malignant potency of cancer cells by secreting senescence-associated secretory phenotype (SASP). Otherwise, Senescence of tumor cells has been believed to inhibit tumor growth by halting the massive proliferation and increasing the chances of immune clearance. In particular, senescent tumor cells (STCs) have been thought that they rarely exist in carcinomas because oncogene-induced senescence needs to be overcome for protumorigenic cells to become malignant. However, recent studies have revealed that a considerable number of STCs are present in cancer tissue, even in metastatic sites. In fact, STCs are widely involved in cancer progression by leading to collective invasion and building a cytokine barrier to protect nonsenescent tumor cells from immune attack. Furthermore, therapy-induced STCs can induce tumor progression and recurrence by increasing stemness. However, obscure causative factors and their heterogeneity in various cancers make it difficult to establish the physiological role of STCs. Here, we summarize and review the current knowledge of the pathophysiology and role of STCs. We also outline the current status of therapeutic strategies for directly removing STCs or modulating the SASPs to maximize the positive functions of STCs while suppressing the negative functions.