bluuebunny/crossref_metadata_2025_split huggingface dataset:
ІННОВАЦІЙНІ ТЕХНОЛОГІЇ УПРАВЛІННЯ ПЕРСОНАЛОМ НА ПІДПРИЄМСТВАХ АВТОМОБІЛЬНОГО ТРАНСПОРТУ
Authors: Дмитрієв Ілля 
Published: November 2021

УДК 331.108.2; JEL Classification: M12

Мета. Формування практичних рекомендацій щодо застосування інноваційних персонал-технологій на підприємствах автомобільного транспорту. Методика дослідження. Теоретичною і методологічною основою є праці провідних вітчизняних і зарубіжних вчених, в яких розглядаються питання інноваційного інструментарію щодо управління персоналом підприємств. В роботі використано методи узагальнення та абстрагування; метод аналізу і синтезу. Результати дослідження. В умовах сучасної ринкової економіки, що характеризується динамічністю, турбулентністю та невизначеністю для підтримання конкурентоспроможності вітчизняних підприємств особлива увага повинна приділятися формуванню ефективної системи управління персоналом. Не зважаючи на великий досвід управління персоналом, застарілі методи не приносять відчутний ефект. Тому постає завдання в дослідженні та впровадження нових інноваційних методів управління персоналом. Автором проведено аналіз останніх досліджень за напрямом інноваційних методів управління персоналом, а також розглянуто досвід практичного їх використання на провідних підприємствах світу та України. Визначено, що інноваційні методи управління персоналом - це нововведення в систему управління персоналом, які є системними та включають спектр методів, процесів, спрямованих на підвищення ефективності діяльності працівників. Для забезпечення впровадження інноваційних методів в систему управління персоналом необхідно застосовувати диференційовані підходи та стилі управління для різних груп працівників, що досягається за допомогою персонал-технологій. В статті розкрито особливості в забезпеченні управління персоналом підприємств автомобільного транспорту. Головною специфікою діяльності, а також головною особливістю автотранспортних підприємств визначено транспортний процес, який відбувається поза межами підприємства. На основі проведеного дослідження інноваційних методів управління персоналом, персонал-технологій та специфіки діяльності підприємств автомобільного транспорту, автором удосконалено їх систематизацію та визначено можливість використання на підприємствах автомобільного транспорту. Розроблена модель впровадження персонал-технологій в систему управління персоналом на підприємствах автомобільного транспорту. Наукова новизна. Розроблені рекомендації щодо використання інноваційних персонал-технологій на підприємствах автомобільного транспорту. Практична значущість. Запропоновані в статті теоретичні висновки, підходи і рекомендації можуть бути використані для розроблення інноваційної системи управління персоналом підприємства та дозволять сформувати ефективний інструментарій розвитку персоналу.
SIMULATION OF DOOR MOVEMENT WITH A CLOSING MECHANISM
Authors: Reutov Aleksandr 
Published: November 2021

The work objective is to determine the parameters of the closing mechanism that provide the specified characteristics of the door movement.
Research method: computer simulation of the movement of a door with a lock mechanism as a multi-mass dynamic system, taking into account the mechanical characteristics and contact interaction of the lock mechanism.
Research results and novelty. Computer dynamic models of a door with a door closer and a door with a spring have been developed. The moments of the door opening force, the closing time of the door, the angular velocity of the door at the time of impact with the frame are considered as the criteria for the quality of the door closing mechanism. Formulas are obtained that determine the permissible values of stiffness and deformation of the door closer spring according to the specified moments of the door opening force.
The movement of doors with a door closer and with a spring is compared. The parameters of the closing mechanism providing the specified characteristics of the door movement of the considered example are determined. It is shown that with the same values of the opening force moments, the speed of impact with the frame in the case of the door closer is less than the door with a spring.
Conclusions: The developed computer dynamic models of a door with a door closer and a door with a spring make it possible to determine the characteristics of the door movement taking into account the inertial and mechanical characteristics of the door closer and spring mechanisms. The permissible values of stiffness and deformation of the door closer spring can be determined by the specified moments of the door opening force in two positions.
It is established that the forces of air resistance and friction in the hinges of the door cannot create the moment of resistance necessary for smooth closing of the door without a strong impact on the frame with a limited closing time.
The quality criteria that minimize the closing time and the speed of impact of the door with the frame are contradictory. The choice of optimal parameters of the door closing mechanism is possible if one of the criteria is replaced by a restriction.
The developed formulas and computer models are recommended for use in the design of devices that restrict the movement of doors.
Hubungan Pemanfaatan Sumber Informasi Dengan Sikap Wanita Usia Subur Tentang Kesehatan Reproduksi
Authors: Prasetya Ekawaty , Nurdin Siti Surya Indah , Ahmad Zul Fikar 
Published: November 2021

Reproductive health is a state of complete physical, mental and social well-being all aspects related to the reproductive system, its functions and processes. This study aims of the study to determine the relationship between the use of information sources and the attitudes of women of childbearing age about reproductive health. This study was conducted in the Working Area of the East City Health Center in 2020. This study is a quantitative analytic with a cross sectional study design. Samples was selected used purposive sampling. Sample sizes is 67 woman. Data analysis used Fisher's Exact Test. The results showed that out of 67 respondents, those who did not utilize health information sources had the highest distribution of 74.1%. Unfavorable attitudes towards reproductive health have the highest distribution of 46.3%. The results of the bivariate analysis showed that there was a significant relationship between the use of health information sources and the attitudes of women of childbearing age about reproductive health (p-Value = 0.000). Utilization of health information sources should be maximized to increase positive attitudes towards reproductive health.Kesehatan Reproduksi merupakan keadaan kesejahteraan fisik, mental, dan sosial yang utuh dalam segala aspek yang berhubungan dengan sistem reproduksi, fungsi, serta prosesnya. Penelitian ini bertujuan untuk mengetahui hubungan pemanfaatan sumber informasi dengan sikap wanita usia subur tentang kesehatan reproduksi. Penelitian ini dilaksanakan di Wilayah Kerja Puskesmas Kota Timur pada tahun 2020. Penelitian ini merupakan penelitian analitik kuantitatif dengan rancangan cross sectional study. Sampel penelitian dipilih dengan menggunakan purposive sampling. Jumlah sampel sebanyak 67 orang. Analisis data menggunakan Fishert Exact Test. Hasil penelitian menunjukkan bahwa dari 67 orang responden bahwa yang tidak memanfaatkan sumber informasi kesehatan memiliki distribusi tertinggi yaitu sebesar 74,1%. Sikap kurang baik terhadap kesehatan reproduksi memiliki distribusi tertinggi yaitu sebesar 46,3%. Hasil analisis bivariat menunjukkan bahwa terdapat hubungan yang signifikan anatar pemanfaatan sumber informasi kesehatan dengan sikap wanita usia subur tentang kesehatan reproduksi (p-Value = 0,000). Pemanfaatkan sumber informasi kesehatan harus dimaksimalkan untuk meningkatkan sikap positif terhadap kesehatan reproduksi.
SARS-CoV-2 infection in a fully vaccinated case with newly diagnosed breast cancer: a case report
Authors: Vandone Anna Maria , Alessio Manuela , Prati Veronica , Zucchini Giorgia , Ciceri Morena , Ortega Cinzia 
Published: November 2021

BACKGROUND: the novel Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was identified in 2019 inWuhan, China, and has not been previously identified in humans. SARS-CoV-2 disease resulted in a global pandemic, impacted on public health service and in major changes in the lifestyle and quality of life of population.

CASE: we describe a 62-year-old woman with new diagnosis of breast cancer, infected with the SARS-CoV-2, within 14 days of the second dose of the BNT162b2 mRNA COVID-19 vaccine.

CONCLUSION: in cancer population, timely vaccinations and maintenance of the maximum alert threshold, are necessary to prevent infection spreading.
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats
Authors: Ponzoni Deise , Fernandes Elissa Kerli , Silva Mateus Muller da , Souza Izabel Cristina Custódio de , Neubert John Kim , Quevedo Alexandre Silva 
Published: November 2021

Bisphosphonates (BIS) are indicated for several clinical disorders (e.g., osteoporosis). However, BIS has been associated with osteonecrosis and alterations in osteoclastogenesis and skeletal development. This study aimed to evaluate the effects of BIS (zoledronic acid - ZA and alendronate sodium - AS) on zones of the growth plate of rat femur. Animals (Wistar rats, n = 19) were divided into groups: 1) AS Group: animals received alendronate sodium orally (3 mg/kg per day); 2) ZA Group: ZA was administered intraperitoneally (0.2 mg/kg per week); and 3) Control Group (CG): a vehicle was administered. Animals were euthanized 21 days after the treatment, and femurs were collected for histological analysis. The images of all zones (resting, proliferative, hypertrophic, and calcified) were processed by the Qcapture® software providing a 40 and 400-fold increase. ZA decreased epiphyseal growth plate cell zones (ZA Group vs. CG) in most cases. Likewise, AS diminished the proliferative zone (AS Group vs. CG). Furthermore, ZA increased the calcified zone (ZA Group vs. CG). Previous works demonstrated that BIS decrease the epiphyseal disc. This reduction is probably due to the shortening of the cellular zones that undergoes calcification/ossification. The present results suggest that BIS should be carefully indicated because these drugs might accelerate epiphyseal closure.
Levantamento georreferenciado de fisioterapeutas no Brasil
Authors: Veloso Aline Helena Nascimento , Veronezi Rafaela Júlia Batista 
Published: November 2021

A disponibilidade de profissionais é um fator desafiador para gestão dos recursos em saúde, sobretudo no Brasil, um país com processo de interiorização e urbanização diferenciado entre as regiões. A distribuição de fisioterapeutas brasileiros ainda é pouco estudada. Georreferenciamento é a conversão da descrição de um local em uma posição na superfície da Terra e uma ferramenta útil na localização de recursos humanos em saúde. Assim, objetivou-se analisar a distribuição de fisioterapeutas no território brasileiro por meio do mapeamento desses profissionais nos Conselhos Regionais de Fisioterapia e Terapia Ocupacional e unidades federativas. Estudo documental descritivo, número de fisioterapeutas por Conselho Regional obtido via consulta aos portais eletrônicos oficiais ou solicitação dos dados via e-mail dos Conselhos. Foi calculado o número de fisioterapeutas por 10 mil habitantes, ou seja, a proporção da distribuição de fisioterapeutas de acordo com os estados e também para cada Conselho Regional. Para a construção do mapa, foi utilizado o programa GeoDa versão 1.18.0. Houve aumento no número de profissionais em relação a estudos anteriores, com predominância de profissionais na região Sudeste, Nordeste e Sul. Essas disparidades podem ser associadas ao nível de urbanização, população total e taxa de envelhecimento regional.
Corticoterapia na sepse: uma revisão integrativa de literatura
Authors: Sousa Laila Caroline Silva , Figueiredo Bárbara Queiroz de , Dutra Dalbert Samuel , Damiani Elizabethe , Ferreira Neto Luis , Sousa Lunalva Gabrielli Veras , Oliveira Rúbia Carla 
Published: November 2021

Introdução: a sepse consiste em uma doença inflamatória sistêmica associada a uma infecção com manifestações graves que ocorre por todo o organismo. No entanto, essa infecção não precisa estar necessariamente em todos os locais do organismo, pode estar restrita em apenas um local, mas causar uma resposta inflamatória por todo o corpo para tentar controlar a causa da infecção Objetivo: demonstrar as atuais evidências sobre o uso de corticosteroides no tratamento da sepse em paciente hospitalizados nas unidades de terapia intensiva (UTI’s). Metodologia: trata-se de uma pesquisa descritiva do tipo revisão integrativa da literatura. Foi realizado o cruzamento dos descritores, em inglês: "sepsis", "hemodynamic", "corticosteroids" em português: "sepse", "hemodinâmica", "corticosteroides" e em espanhol: "sepsis", "hemodinámico", "corticosteroides", nas seguintes bases de dados: National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Biblioteca Virtual em Saúde (BVS) e EBSCO Information Services. Totalizaram-se 24 artigos científicos para a revisão integrativa da literatura, publicados entre 2011 e 2021. Resultados a melhora na sobrevida com corticosteroides pode resultar da redução da duração do choque, gravidade da inflamação e número de disfunções orgânicas. Os benefícios demonstrados estão de acordo com os achados de estudos em animais, músculos lisos vasculares isolados e células inflamatórias e em voluntários saudáveis ​​desafiados com endotoxina. A hidrocortisona possui vários benefícios em relação aos recursos de saúde, tais como: é uma droga barata e segura, possibilita menor permanência na UTI, menor tempo de ventilação mecânica e resolução mais rápida da sepse. Conclusão: os glicocorticoides, em especial a hidrocortisona, podem ser utilizados para o tratamento dos pacientes com sepse. Conforme as literaturas utilizadas, os resultados são satisfatórios e possuem um custeio de fácil adesão.
Atuação do farmacêutico hospitalar na Unidade de Terapia Intensiva (UTI)
Authors: Oliveira Wellyson Leoncio de , Carvalho Adryanna Rafaelly Araújo de , Siqueira Lidiany Paixão 
Published: November 2021

Conhecida como uma das profissões mais antigas, a farmácia tem como principal objetivo a qualidade de vida do paciente. O farmacêutico é o profissional preparado para orientar no uso correto dos medicamentos e pode atuar em diversas áreas, tais como: a farmácia hospitalar que presta um serviço de atividade fundamental no que diz respeito ao uso correto e racional dos medicamentos. O objetivo desta pesquisa é expor a importância do farmacêutico hospitalar junto com a equipe multidisciplinar da Unidade de Terapia Intensiva (UTI). A metodologia utilizada foi o levantamento bibliográfico de artigos em plataformas on-line "Scielo, google academic e Lilacs" e sites oficiais como SBRAFH, AMIB e CFF. A pesquisa mostra a vantagem deste profissional na equipe multidisciplinar, resolvendo ou prevenindo resultados clínicos negativos causados pelo uso de medicamentos. Portanto, a atuação do farmacêutico hospitalar é vantajosa tanto para a equipe quanto para o paciente, reduzindo erros de prescrição, falhas na administração de medicamentos, que podem trazer danos à saúde, tem uma boa interação com os demais profissionais que prestam serviço, melhorando assim as chances de sobrevivência do paciente criticamente doente, um tratamento mais eficaz e menos duradouro.
Development and Validation of a Prediction Model for Acute Kidney Injury Among Patients With Acute Decompensated Heart Failure
Authors: Wang Lei , Zhao Yun-Tao 
Published: November 2021

Background: Acute kidney injury is an adverse event that carries significant morbidity among patients with acute decompensated heart failure (ADHF). We planned to develop a parsimonious model that is simple enough to use in clinical practice to predict the risk of acute kidney injury (AKI) occurrence.Methods: Six hundred and fifty patients with ADHF were enrolled in this study. Data for each patient were collected from medical records. We took three different approaches of variable selection to derive four multivariable logistic regression model. We selected six candidate predictors that led to a relatively stable outcome in different models to derive the final prediction model. The prediction model was verified through the use of the C-Statistics and calibration curve.Results: Acute kidney injury occurred in 42.8% of the patients. Advanced age, diabetes, previous renal dysfunction, high baseline creatinine, high B-type natriuretic peptide, and hypoalbuminemia were the strongest predictors for AKI. The prediction model showed moderate discrimination C-Statistics: 0.766 (95% CI, 0.729–0.803) and good identical calibration.Conclusion: In this study, we developed a prediction model and nomogram to estimate the risk of AKI among patients with ADHF. It may help clinical physicians detect AKI and manage it promptly.
Radiation Augments the Local Anti-Tumor Effect of In Situ Vaccine With CpG-Oligodeoxynucleotides and Anti-OX40 in Immunologically Cold Tumor Models
Authors: Pieper Alexander A. , Zangl Luke M. , Speigelman Dan V. , Feils Arika S. , Hoefges Anna , Jagodinsky Justin C. , Felder Mildred A. , Tsarovsky Noah W. , Arthur Ian S. , Brown Ryan J. , Birstler Jen , Le Trang , Carlson Peter M. , Bates Amber M. , Hank Jacquelyn A. , Rakhmilevich Alexander L. , Erbe Amy K. , Sondel Paul M. , Patel Ravi B. , Morris Zachary S. 
Published: November 2021

IntroductionCombining CpG oligodeoxynucleotides with anti-OX40 agonist antibody (CpG+OX40) is able to generate an effective in situ vaccine in some tumor models, including the A20 lymphoma model. Immunologically “cold” tumors, which are typically less responsive to immunotherapy, are characterized by few tumor infiltrating lymphocytes (TILs), low mutation burden, and limited neoantigen expression. Radiation therapy (RT) can change the tumor microenvironment (TME) of an immunologically “cold” tumor. This study investigated the effect of combining RT with the in situ vaccine CpG+OX40 in immunologically “cold” tumor models.MethodsMice bearing flank tumors (A20 lymphoma, B78 melanoma or 4T1 breast cancer) were treated with combinations of local RT, CpG, and/or OX40, and response to treatment was monitored. Flow cytometry and quantitative polymerase chain reaction (qPCR) experiments were conducted to study differences in the TME, secondary lymphoid organs, and immune activation after treatment.ResultsAn in situ vaccine regimen of CpG+OX40, which was effective in the A20 model, did not significantly improve tumor response or survival in the “cold” B78 and 4T1 models, as tested here. In both models, treatment with RT prior to CpG+OX40 enabled a local response to this in situ vaccine, significantly improving the anti-tumor response and survival compared to RT alone or CpG+OX40 alone. RT increased OX40 expression on tumor infiltrating CD4+ non-regulatory T cells. RT+CpG+OX40 increased the ratio of tumor-infiltrating effector T cells to T regulatory cells and significantly increased CD4+ and CD8+ T cell activation in the tumor draining lymph node (TDLN) and spleen.ConclusionRT significantly improves the local anti-tumor effect of the in situ vaccine CpG+OX40 in immunologically “cold”, solid, murine tumor models where RT or CpG+OX40 alone fail to stimulate tumor regression.
Comparison of Interleukin-6 Plasma Concentration in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Pediatric Sepsis
Authors: Diaz Franco , Bustos B Raúl , Yagnam Felipe , Karsies Todd J. , Vásquez-Hoyos Pablo , Jaramillo-Bustamante Juan-Camilo , Gonzalez-Dambrauskas Sebastián , Drago Michelle , Cruces Pablo 
Published: November 2021

Importance: Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection is thought to be driven by a post-viral dysregulated immune response, where interleukin 6 (IL-6) might have a central role. In this setting, IL-6 inhibitors are prescribed as immunomodulation in cases refractory to standard therapy.Objective: To compare plasma IL-6 concentration between critically ill children with MIS-C and sepsis.Design: A retrospective cohort study from previously collected data.Setting: Individual patient data were gathered from three different international datasets.Participants: Critically ill children between 1 month-old and 18 years old, with an IL-6 level measured within 48 h of admission to intensive care. Septic patients were diagnosed according to Surviving Sepsis Campaign definition and MIS-C cases by CDC criteria. We excluded children with immunodeficiency or immunosuppressive therapy.Exposure: None.Main Outcome(s) and Measure(s): The primary outcome was IL-6 plasma concentration in MIS-C and sepsis group at admission to the intensive care unit. We described demographics, inflammatory biomarkers, and clinical outcomes for both groups. A subgroup analysis for shock in each group was done.Results: We analyzed 66 patients with MIS-C and 44 patients with sepsis. MIS-C cases were older [96 (48, 144) vs. 20 (5, 132) months old, p &lt; 0.01], but no differences in sex (41 vs. 43% female, p = 0.8) compared to septic group. Mechanical ventilation use was 48.5 vs. 93% (p &lt; 0.001), vasoactive drug use 79 vs. 66% (p = 0.13), and mortality 4.6 vs. 34.1% (p &lt; 0.01) in MIS-C group compared to sepsis. IL-6 was 156 (36, 579) ng/dl in MIS-C and 1,432 (122, 6,886) ng/dl in sepsis (p &lt; 0.01), while no significant differences were observed in procalcitonin (PCT) and c-reactive protein (CRP). 52/66 (78.8%) patients had shock in MIS-C group, and 29/44 (65.9%) had septic shock in sepsis group. Septic shock had a significantly higher plasma IL-6 concentration than the three other sub-groups. Differences in IL-6, CRP, and PCT were not statistically different between MIS-C with and without shock.Conclusions and Relevance: IL-6 plasma concentration was elevated in critically ill MIS-C patients but at levels much lower than those of sepsis. Furthermore, IL-6 levels don't discriminate between MIS-C cases with and without shock. These results lead us to question the role of IL-6 in the pathobiology of MIS-C, its diagnosis, clinical outcomes, and, more importantly, the off-label use of IL-6 inhibitors for these cases.