bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison Between Decitabine and Azacitidine for Patients With Acute Myeloid Leukemia and Higher-Risk Myelodysplastic Syndrome: A Systematic Review and Network Meta-Analysis
Authors: Ma Jiale , Ge Zheng 
Published: August 2021

Background: The hypomethylating agents (HMAs) azacitidine (AZA) and decitabine (DAC) have been widely used in patients with acute myeloid leukemia (AML) and higher-risk myelodysplastic syndrome (HR-MDS). However, few direct clinical trials have been carried out to compare the efficacy and adverse events (AEs) between these two agents. The clinical choice between them is controversial. A systematic review and network meta-analysis (NMA) was performed to compare the efficacy, safety, and survival of DAC and AZA in AML and HR-MDS patients.Methods: We systematically searched MEDLINE, Embase, Web of Science, and Cochrane Library through March 15, 2021. Randomized controlled trials (RCTs) on AML or HR-MDS patients comparing the efficacy and safety between DAC and AZA or comparing one of HMAs to conventional care regimens (CCR) were selected.Results: Eight RCTs (n = 2,184) were identified in the NMA. Four trials compared AZA to CCR, and four compared DAC to CCR. Direct comparisons indicated that, compared to CCR, both AZA and DAC were associated with higher overall response (OR) rate (AZA vs. CCR: relative risk (RR) = 1.48, 95% CI 1.05–2.1; DAC vs. CCR: RR = 2.14, 95% CI 1.21–3.79) and longer overall survival (OS) (AZA vs. CCR: HR = 0.64, 95% CI 0.50–0.82; DAC vs. CCR: HR = 0.84, 95% CI 0.72–0.98), and AZA showed higher rate of complete remission with incomplete blood count recovery (CRi) (HR = 2.52, 95% CI 1.27–5). For the indirect method, DAC showed a higher complete remission (CR) rate than AZA in patients with both AML (RR = 2.28, 95% CI 1.12–4.65) and MDS (RR = 7.57, 95% CI 1.26–45.54). Additionally, DAC significantly increased the risk of 3/4 grade anemia (RR = 1.61, 95% CI: 1.03–2.51), febrile neutropenia (RR = 4.03, 95% CI: 1.41–11.52), and leukopenia (RR = 3.43, 95% CI 1.64–7.16) compared with AZA. No statistical significance was found for the other studied outcomes.Conclusion: Compared to CCR, both AZA and DAC can promote outcomes in patients with AML and HR-MDS. DAC showed higher efficacy especially CR rate than AZA (low-certainty evidence), while AZA experienced lower frequent grade 3/4 cytopenia than patients receiving DAC treatment.
A Narrow-Linewidth Linearly Polarized 1018-nm Fiber Source for Pumping Diamond Raman Laser
Authors: Yang Xuezong , Bai Zhenxu , Jiang Huawei , Mildren Richard P. , Feng Yan 
Published: August 2021

A 7.8-GHz linewidth ytterbium-doped fiber (YDF) laser with an output power of 75 W at 1,018 nm is demonstrated based on narrow-bandwidth fiber Bragg gratings. Effective suppression of spectral broadening and amplified spontaneous emission is achieved by optimizing the resonator structure and active fiber parameters. An 1,178-nm diamond Raman output pumped by this narrow-linewidth 1,018 nm source is addressed in this study, which shows a promising application of generating the sodium guide star laser at 589 nm. A single-longitudinal-mode Stokes with an output power of 0.6 W is obtained using this multimode 1,018 nm laser at the pump power of 13 W. The impact of pump spectral linewidth on the effective Raman gain coefficient is analyzed, and the laser threshold of the diamond Stokes resonator increases with the broadening of the pump linewidth.
Longitudinal Follow-Up on Cardiopulmonary Exercise Capacity Related to Cardio-Metabolic Risk Factors in Children With Renal Transplants
Authors: Westphal Ladfors Susanne , Bergdahl Ebba , Hermannsson Oli , Kristjansson Julius , Linnér Tina , Brandström Per , Hansson Sverker , Dangardt Frida 
Published: August 2021

Background: Children with chronic kidney disease, including those treated with kidney transplantation (KT), have an increased risk of cardiovascular disease. The aim of this study was to examine the cardiopulmonary exercise capacity after KT compared to matched controls, to relate the results to physical activity, blood pressure and biochemical findings and to follow exercise capacity over time.Methods: Patients with KT (n = 38, age 7.7–18 years), with a mean time from transplantation of 3.7 years (0.9–13.0) and mean time in dialysis 0.8 years, were examined at inclusion and annually for up to three years. Healthy controls (n = 17, age 7.3–18.6 years) were examined once. All subjects underwent a cardiopulmonary exercise test, resting blood pressure measurement, anthropometry and activity assessment. Patients also underwent echocardiography, dual-energy X-ray absorptiometry (DXA), 24-h ambulatory BP measurements (ABPM), assessment of glomerular filtration rate (GFR) and blood sampling annually.Results: As compared to healthy controls, KT patients showed decreased exercise capacity measured both as VO2peak (34.5 vs. 43.9 ml/kg/min, p &lt; 0.001) and maximal load (2.6 vs. 3.5 W/kg, p &lt; 0.0001), similarly as when results were converted to z-scores. No significant difference was found in weight, but the KT patients were shorter and had higher BMI z-score than controls, as well as increased resting SBP and DBP z-scores. The patient or parent reported physical activity was significantly lower in the KT group compared to controls (p &lt; 0.001) In the combined group, the major determinants for exercise capacity z-scores were activity score and BMI z-score (β = 0.79, p &lt; 0.0001 and β = −0.38, p = 0.007, respectively). Within the KT group, low exercise capacity was associated with high fat mass index (FMI), low activity score, low GFR and high blood lipids. In the multivariate analysis FMI and low GFR remained predictors of low exercise capacity. The longitudinal data for the KT patients showed no change in exercise capacity z-scores over time.Conclusion: Patients with KT showed decreased exercise capacity and increased BP as compared to healthy controls. Exercise capacity was associated to GFR, physical activity, FMI and blood lipids. It did not improve during follow-up.
Safety and Effectiveness of Tailored Hemorrhoidectomy in Outpatients Setting
Authors: Tomasicchio Giovanni , Martines Gennaro , Lantone Giuliano , Dibra Rigers , Trigiante Giuseppe , De Fazio Michele , Picciariello Arcangelo , Altomare Donato Francesco , Rinaldi Marcella 
Published: August 2021

Introduction: Single or double prolapsed pile instead of full muco-hemorrhoidal prolapse is a common finding in patients with symptomatic III or IV degree hemorrhoids. For this selected group of patients, relief of symptoms could be achieved by managing the single/double prolapsed piles instead of performing traditional hemorrhoidectomy. The aim of this single-center study was to evaluate the safety and medium- and long-term effectiveness of an outpatient tailored Milligan-Morgan hemorrhoidectomy (MMH) performed under local anesthesia (LA).Material and methods: Clinical records of 202 patients submitted to outpatient tailored MMH, under LA and without anal dilation, treated between 2013 and 2020, were retrospectively reviewed using a prospectively maintained database and completed by a telephone interview or outpatient consultation. Postoperative pain score, the need for painkillers, postoperative complications and symptoms recurrence, return to working activities, and patient grading assessment scale were recorded.Results: Thirty-five (17%) out of 202 patients recruited were lost to the follow-up. One hundred and fifty-two and 15 patients underwent a single and double pile hemorrhoidectomy, respectively. With regard to postoperative outcomes, visual analogue scale (VAS) decreased from a median value of 4 [interquartile range (IQR) 2–6] on the day of surgery to 1 (IQR 0–4) on the 10th postoperative day (p &lt; 0.001). Sixty-one patients (37%) needed oral painkillers during the 1st week after surgery. There was no mortality or major postoperative complication. Bleeding requiring hospital readmission was reported in seven (4%) patients, and one patient underwent emergency surgery with no need for blood transfusion. No postoperative urinary retention, anal incontinence, or stricture occurred in the series. During the median follow-up of 39 (IQR 12–60) months, 26 patients (16%) reported symptoms of recurrence but only six underwent traditional MMH. Recovery to normal activity occurred within a median period of 6 days (IQR 3–10) and the Clinical Patient Grading Assessment Scale (CPGAS) at 1 year after surgery was reported to be a “good deal better.”Conclusions: Tailored MMH performed under LA in an ambulatory setting can be considered a safe and effective technique with high compliance and satisfaction of patients.
Measure of Singular Value Decomposition (M-SVD) based Quality Assessment for Medical Images with Degradation
Authors: Elbasi Ersin 
Published: August 2021

We use images in several important areas such as military, health, security, and science. Images can be distorted during the capturing, recording, processing, and storing. Image quality metrics are the techniques to measure the quality and quality accuracy level of the images and videos. Most of the quality measurement algorithms does not affect by small distortions in the image. Magnetic Resonance Imaging (MRI), Computed Tomography (CT), and Ultrasonic Imaging (UI) are widely used in the health sector. Because of several reasons it might be artifacts in the medical images. Doctor decisions might be affected by these image artifacts. Image quality measurement is an important and challenging area to work on. There are several metrics that have been done in the literature such as mean square error, peak signal-noise ratio, gradient similarity measure, structural similarity index, and universal image quality. Patient information can be an embedded corner of the medical image as a watermark. Watermark can be considered one of the image distortions types. The most common objective evaluation algorithms are simple pixel based which are very unreliable, resulting in poor correlation with the human visual system. In this work, we proposed a new image quality metric which is a Measure of Singular Value Decomposition (M-SVD). Experimental results show that novel M-SVD algorithm gives very promising results against Peak Signal to Noise Ratio (PSNR), the Mean Square Error (MSE), Structural Similarity Index Measures (SSIM), and 3.4.	Universal Image Quality (UIQ) assessments in watermarked and distorted images such as histogram equalization, JPEG compression, Gamma Correction, Gaussian Noise, Image Denoising, and Contrast Change.
The Development of Math Box Learning Media on multiple Calculating Operation materials in 3nd Class SDIT Idrisiyyah Tamansari
Authors: Via Noerbaety  , Budi Hendrawan  , Anggia Suci Pratiwi  
Published: August 2021

Pengembangan dan penelitian yang dilakukan bertujuan untuk membuat sebuah produk pembelajaran yaitu math box. Selain itu, juga bertujuan mengetahui keefektifan bagi siswa dengan cara mengetahui kualitas media yang telah dikembangkan terlebih dahulu berdasarkan penilaian ahli materi, ahli media, guru dan penilaian oleh 14 orang siswa pada materi konsep operasi hitung perkalian. Metode yang dilakukan dalam penelitian yaitu Research and Development (RnD) menggunakan metode Bord and Gall yang dikembangkan oleh Sugiyono. Pengembangan pada penelitian ini dilakukan sampai tahap uji coba produk.teknik pengumpulan data menggunakan angket yang ditujukan kepada para ahli serta teknik tes yaitu pretest dan postest. Dalam Teknik analisis data pada penelitian ini menggunakan statistika deskriftif yaitu dengan cara mendeskriftifkan data yang terkumpul. Hasil dari penelitian ini mengalami perubahan yang signuifikan, karena dapat dilihat dari hasil pretest dan postest. Nilai postest lebih bagus dengan rata-rata 89,42 sedangkan nilai rata-rata pretest yaitu 66,92.
HUBUNGAN ANTARA KECEMASAN MENHADAPI MASA BERAKHIRNYA KONTRAK KERJA DENGAN KINERJA KARYAWAN PADA KARYAWAN KONTRAK (PT. PLN (PERSERO) UNIT PELAKSANA PENGENDALIAN PEMBANGKITAN KENDARI
Authors: Mevia Razak Azahra Rezhya Arta , Aspin Aspin , Marhan Citra 
Published: August 2021

Karyawan kontrak rentan mengalami kecemasan karena mereka khawatir akan nasibnya dikemudian hari apabila kontrak tidak diperpanjang, akibatnya manifestasi dari kecemasan menghadapi masa berakhirnya kontrak kerja akan menyebabkan penurunan kinerja karyawan kontrak, apabila fungsi kognitif pada karyawan kontrak tidak berjalandengan baik.Penelitian ini bertujuan untuk mengetahui hubungan antara kecemasan dalam menghadapi masa berakhirnya kontrak kerja dengan kinerja karyawan kontrak pada PT. PLN (Persero) Unit Pelaksana Pengendalian Pembangkitan Kendari. Penelitian ini dilakukan pada 74 karyawan kontrak PT. PLN (Persero) Unit Pelaksana Pengendalian Pembangkitan Kendari. Jenis penelitian ini berupa penelitian kuantitatif korelasional.Teknik pengumpulan data pada penelitian ini dilakukan dengan menggunakann skala TMAS (Taylor Manifest Anxiety Scale) dan skala kinerja karyawan kontrak. Data hasil penelitian dengan menggunakan korelasi Pearson Product Moment. Hasil dari penelitian ini menunjukkan nilai signifikansi sebesar 0,634. Nilai tersebut lebih besar dari 0,05, sehingga dapat dikatakan bahwa tidak ada hubungan antara kecemasan menghadapi masa berakhirnya kontrak kerja dengan kinerja karyawan kontrak. Kata Kunci: Kecemasan, Kinerja Karyawan
HUBUNGAN ANTARA EFIKASI DIRI DENGAN PROBLEM FOCUSED COPING PADA MAHASISWA YANG SEDANG MENYUSUN SKRIPSI DI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS HALU OLEO KENDARI
Authors: Pasiori Wahiudin , Jamiludin Jamiludin , Marhan Citra 
Published: August 2021

Wahiudin Pasiori (A1R1 15 032), “Hubungan Antara Efikasi Diri dengan Problem Focused Coping pada Mahasiswa yang Sedang Menyusun Skripsi di Fakultas Keguruan dan Ilmu Pendidikan Universitas Halu Oleo Kendari”. Penelitian ini bertujuan untuk menguji hubungan antara efikasi diri dan problem focused coping pada mahasiswa yang sedang menyusun skripsi. Hipotesis dalam penelitian ini adalah terdapat hubungan positif antara efikasi diri dengan problem focused coping. Responden dalam penelitian ini adalah 95 mahasiswa yang sedang menyusun skripsi di Fakultas Keguruan dan Ilmu Pendidikan Universitas Halu Oleo yang dipilih dengan teknik proportional random sampling. Pengumpulan data dilakukan menggunakan skala efikasi diri dan skala problem focused coping. Skala efikasi diri memiliki koefisien reliabilitas sebesar 0,937 dan skala problem focused coping memiliki koefisien reliabilitas sebesar 0,920 Teknik analisis data dalam penelitian ini menggunakan uji korelasi Product Moment Pearson dengan bantuan SPSS 16.0 for windows. Hasil analisis data menunjukkan bahwa hipotesis dalam penelitian ini diterima. Hal tersebut menunjukkan bahwa terdapat korelasi positif antara efikasi diri dan problem focused coping pada mahasiswa yang sedang menyusun skripsi (r = 0,858, p = 0,000). Kata Kunci: efikasi diri, problem focused coping, mahasiswa yang sedang menyusun skripsi
Pentingnya Kecerdasan Spritual terhadap Prestasi Belajar
Authors: Sriwaty S Ida , Aspin Aspin , Syamsiah Syamsiah 
Published: August 2021

Prestasi belajar dipengaruhi oleh faktor internal dan dan faktor eksternal. Salah satu faktor internal yang mempengaruhi prestasi belajar adalah kecerdasan spiritual. Kecerdasan spiritual adalah kecerdasan yang membantu individu untuk menghadapi dan memecahkan masalah dalam hidup. Mahasiswa yang memiliki kecerdasan spiritual dapat mempertahankan nilai akademik meski dalam keadaan tertekan begitupun sebaliknya. Penelitian ini bertujuan untuk mengetahui : (1) Apakah terdapat peran kecerdasan spiritual terhadap prestasi belajar pada anggota UKM UKKI Universitas Halu Oleo. (2) Seberapa besar sumbangan efektif peran kecerdasan spiritual terhadap prestasi belajar pada anggota UKM UKKI Universitas Halu Oleo. Jenis penelitian ini yaitu kuantitatif dengan desain penelitian ex-post facto. Subjek dalam penelitian ini berjumlah 81 orang. Instrumen penelitian ini menggunakan dokumentasi IPK sementara anggota UKM UKKI dan skala kecerdasan spiritual yang disebar secara online dengan menggunakan google form. Teknik analisis data menggunakan analisis regresi sederhana. Hasil penelitian dengan menggunakan analisis regresi sederhana dengan taraf signifikan p = 0,01 menunjukkan bahwa: (1) Nilai signifikansi sebesar 0,000. Nilai ini lebih kecil dari 0,01. Ini menunjukkan kecerdasan spiritual berperan sangat signifikan terhadap prestasi belajar. (2) Nilai R Square sebesar 0,019, ini menunjukkan sumbangan efektif kecerdasan spiritual terhadap prestasi belajar yaitu sebesar 1,9%. Dalam hal ini hipotesis yang diajukan dalam penelitian ini diterima.
Psychological Well-Being dan Komitmen Organisasi Pegawai Sekretariat DPRD
Authors: Sila Panji Dadino , Suarni Wa Ode , Sunarjo Ida Sriwaty 
Published: August 2021

Psychological well-being pada diri pegawai merupakan salah satu hal yang mendorong peningkatan kinerja pada pegawai. Ketika psychological well-being pada pegawai tidak terpenuhi akan menyebabkan rendahnya komitmen pegawai pada organisasi sehingga kinerja yang diberikan menjadi kurang optimal yang berakibat pada sulitnya tercapai visi dan misi organisasi. Penelitian ini bertujuan untuk mengetahui hubungan antara psychological well-being dengan komitmen organisasi pada pegawai Sekretariat Dewan Perwakilan Rakyat Daerah Kabupaten Kolaka. Jenis penelitian kuantitatif dengan desain korelasional. Populasi penelitian berjumlah 58 pegawai negeri sipil Sekretariat Dewan Perwakilan Rakyat Daerah Kabupaten Kolaka. Subjek penelitian dipilih menggunakan teknik total sampling. Data hasil penelitian dianalisis dengan menggunakan formula korelasi Product Moment Pearson. Hasil uji statistik menunjukkan psychological well-being dengan kategori tinggi sebanyak 21% sedangkan komitmen organisasi kategori tinggi sebanyak 21%. Koefisien korelasi yang diperoleh sebesar 0,728 dengan nilai signifikansi 0,000. Nilai korelasi yang diperoleh bertanda positif menunjukkan ada hubungan positif antara psychological well-being dengan komitmen organisasi pada pegawai Sekretariat Dewan Perwakilan Rakyat Daerah Kabupaten Kolaka sehingga hipotesis penelitian diterima.
PRIORITIES OF INNOVATIVE AND TECHNOLOGICAL DEVELOPMENT OF THE REGIONAL ECONOMY
Authors: Иванова Наталия Александровна 
Published: August 2021

В статье рассматриваются вопросы выработки действенной региональной политики, обоснования ее приоритетов и механизмов реализации. Акцент делается на мировые тенденции инновационно-технологического развития. Императивом региональной политики должна стать технологическая модернизация действующих предприятий, реализация инвестиционных проектов, направленных на более полное исследование ресурсного потенциала, создание новых отраслей промышленности, повышение производительности труда. Все это требует научного обоснования приоритетов региональной промышленной политики, поиска механизмов, стимулирующих экономический рост, вариантов расширения сузившихся в период экономического кризиса финансово-инвестиционной базы технологических преобразований экономики регионов.
The article deals with the development of an effective regional policy, justification of its priorities and implementation mechanisms. The emphasis is on global trends in innovative and technological development. The imperative of regional policy should be the technological modernization of existing enterprises, the implementation of investment projects aimed at a more complete study of the resource potential, the creation of new industries, and an increase in labor productivity. All this requires a scientific substantiation of the priorities of regional industrial policy, a search for mechanisms that stimulate economic growth, options for expanding the financial and investment base of technological transformations of the regional economies that have narrowed during the economic crisis.
CIVIL LIABILITY FOR VIOLATION OF EXCLUSIVE RIGHTS
Authors: Нинциева Тамила Магомедовна 
Published: August 2021

В статье рассмотрены условия и особенности привлечения нарушителей исключительных прав к гражданско-правовой ответственности, особое внимание уделено вопросу определения размера вреда причиненного нарушением исключительных прав.
The article discusses the conditions and features of bringing violators of exclusive rights to civil liability, special attention is paid to the issue of determining the amount of harm caused by violation of exclusive rights.
EFFICIENCY OF FOAM WASTEWATER DISPOSAL
Authors: Богданов Роман Александрович 
Published: August 2021

Получены динамические характеристики производительности пеногенератора от времени в сточной воде при различных концентрациях некаля, являющегося поверхностно-активным веществом, и переменной глубине погружения сопла.
The dynamic characteristics of the foam generator performance as a function of time in the waste water at different concentrations of non-crystal, which is a surfactant, and variable nozzle immersion depth are obtained.
RETURNING TO THE PROBLEM OF CRIMINAL CASHING OUT
Authors: Милова Ирина Евгеньевна , Саликова Анастасия Анатольевна , Клачинская Ирина Юрьевна 
Published: August 2021

В статье на примере конкретного уголовного дела рассматривается схема, по которой осуществляется криминальное обналичивание, с акцентом на значимость оперативных мероприятий по выявлению и раскрытию подобных злоупотреблений. При этом показывается важность компьютерно-технических экспертиз при расследовании соответствующих преступлений.
The article uses the example of a specific criminal case to consider the scheme by which criminal cashing is carried out, with an emphasis on the importance of operational measures to identify and disclose such abuses. At the same time, the importance of computer-technical expertise in the investigation of relevant crimes is shown.
THE IMPORTANCE OF HEATING AND VENTILATION SYSTEMS FOR BROILER PRODUCTION
Authors: Агафонова Ирина Владимировна , Соловьев Максим Дмитриевич 
Published: August 2021

Статья посвящена значению систем отопления и вентиляции в птицеводстве. Авторами выполнен расчет режимов работы систем вентиляции для птицефабрики, находящейся в городе Йошкар Ола. Существенным ресурсом энергосбережения на птицефабрике оказалось регулирование режима вентиляции в зависимости от роста птицы.
The article is devoted to the importance of heating and ventilation systems in poultry farming. The authors calculated the operating modes of ventilation systems for a poultry farm located in the city of Yoshkar Ola. The regulation of the ventilation mode depending on the poultry growth turned out to be a significant resource for energy saving at the poultry farm.