bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amelioration of Autoimmunity and Inflammation by Zinc Oxide Nanoparticles in Experimental Rheumatoid Arthritis
Authors: Shaaban Sameh , Fayez Ahmed M. , Abdelaziz Mahmoud , El-ezz Doaa Abou 
Published: February 2021

Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the lining of the synovial joints and approximately affects 0.5-1% of the total population imposing a socioeconomic burden. Currently, there is no cure for RA, but receiving proper medical care at early stages of the disease is of high importance, to prevent the progressive disability and premature death. Using rat animal model injected with Complete Freund’s adjuvant proved to be successful in induction of a state highly resembling RA in human. Zinc oxide nanoparticles (ZnO NPs) are considered as one of the most important metal oxide nanoparticles due to their exclusive properties, and they are currently merged in several biological applications due to their biocompatibility, low cost, and high safety profile. In this study, we demonstrated the novel possible beneficial effects of using zinc oxide nanoparticles, on such devastating severe disease. Zinc oxide nanoparticles (ZnO NPs) proved to reduce the adjuvant-induced increased productions of IL-1β, TNF-α, IL-10, total leukocyte count, rheumatoid factor, anti-CCP levels in rats, suggesting an interesting option to be available either alone or in combinations to better control RA.In conclusion we recommend the expansion of more in vivo studies to highlight the benefits which could be obtained of nanoparticles either alone or in combination with the known anti-arthritic and/or anti-inflammatory agents; giving rise to new protocols to maximize the control of RA.
Optimizing Chemotherapy of Pancreatic Acinar Cell Carcinoma: Our Experiences and Pooled Analysis of Literatures
Authors: Xu Jianying , Guan Wenlong , Lu Shixun , Wei Xiaoli , Shi Wenjie , Ren Chao , Li Yuhong , Li Shengping , Qiu Miaozhen , Wang Fenghua 
Published: February 2021

Abstract
Background: Pancreatic acinar cell carcinoma (PACC) is rare and its appropriate treatment remains unknown dued to limited and selection-biased dataMethods: The data on clinicopathologic characteristics, molecular alteration, treatment and survival of patients diagnosed as PACC in Sun Yat-sen university cancer center from 2005 to 2020 were collected. We explored the optimal treatment by co-analyzing our results and published literatures.Results: 22 PACC patients were enrolled. 8/17 non-metastatic patients received adjuvant chemotherapy. The patients receiving fluoropyrimidine-based regimen (n=3) had better mDFS than those with gemcitabine-based regimen (n=5) (unreached vs. 27 months). 8 metastatic patients received 1st-line chemotherapy. 4/5 patients with FOLFIRINOX regimen achieved partial response (PR) and 3 patients with AG (albumin paclitaxel+gemcitabine) regimen got progressive disease (PD). 4 patients received 2nd-line chemotherapy. 2 patients with FOLFIRINOX regimen achieved PR while 2 patients with AG regimen got PD. One patient who had responded to 1st-line FOLFIRINOX regimen received Olaparib as maintenance treatment for 5 months with good tolerance. 31 published literatures and a total of 86 cases were included in the co-analysis. Objective response rate of 1st-line fluoropyrimidine-based regimen (n=47) was higher than that of gemcitabine-based regimen (n=39) (59.6% vs.15.3%, P<0.001). 8/11 patients treated with FOLFIRINOX regimen achieved PR. Conclusions: The benefit of adjuvant chemotherapy remained unclear; however, fluoropyrimidine-based chemotherapy deserves attention. For metastatic patients, fluorouracil-based regimen such as FOLFIRINOX is preferred, and maintenance treatment of PARP inhibitors after effective platinum-containing treatment for BRAC mutation patients is worthy of exploration.
Acceptability of saliva-based HIVST among men who have sex with men (MSM) and transgender women (TGW) in Russia: a qualitative study
Authors: Meylakhs Peter , Meylakhs Anastasia , Davitadze Arsen 
Published: February 2021

Abstract
The COVID-19 pandemic increased actuality of HIV self-testing (HIVST). Men who have sex with men (MSM) and transgender women (TGW) in Russia are highly stigmatized populations vulnerable to HIV infection and hard to reach with facility-based testing strategies. The study explored acceptability of HIV self-testing (HIVST) among these key groups in Russia. 32 semi-structured interviews with MSM and 3 TGW women from 5 Russian cities who underwent HIVST were conducted. Benefits of HIVST included ease of use, convenience and confidentiality. Confidentiality helped participants to avoid stigma related to their identity thus empowering them in conditions of high stigmatization of LGBTQ-people. Participants expressed concerns about accuracy of saliva-based HIVST and lack of counseling in case of reactive result. Our results suggest high acceptability of HIVST among Russian MSM and TGW and indicate that increase in HIVST uptake could be facilitated by popularization of HIVST and addressing the participants’ concerns.
Application of Modified Closed Biopsy in Rabbit Model of VX2 Transplanted Bone Tumor
Authors: peng Bai Lei , xing Lv Jia , wei Kong Ling , ying Cao Hai , Yu Jin 
Published: February 2021

Abstract
Aim To explore the application value of modified closed biopsy technique in puncture biopsy of rabbit VX2 transplanted bone tumor model.Methods VX2 tumor was transplanted into the bilateral tibia of 30 rabbits through the tibial plateau to make the model of VX2 transplanted bone tumor. Seven days after modeling, the proximal tibia biopsy was performed under the guidance of X-ray, and the biopsy specimen was examined pathologically. The left leg was biopsied with modified closed biopsy technique (experimental group) and the right leg was biopsied with hollow needle (control group). After 14 days of modeling, all rabbits were killed after X-ray examination around the puncture hole, and the soft tissue around the puncture hole was taken for pathological examination, and the expression levels of PCNA and CD34 in the tissue extract were detected by enzyme-linked immunosorbent assay (ELISA).Results By the end of the experiment, a total of 3 rabbits died, and finally 27 rabbits were included in the study. Tumor cells were detected in all the intramedullary specimens obtained by puncture biopsy. On the 14th day after modeling, X-ray showed that the occurrence rate of periosteal reaction and extraosseous high density shadow around the puncture hole was 14.81% (4/27) in the experimental group and 40.74% (11/27) in the control group. the difference was statistically significant (P<0.05). The pathological results of soft tissue around the puncture hole showed that the tumor cell metastasis rate was 29.63% (8/27) in the experimental group and 100% (27/27) in the control group, and the difference was statistically significant (P<0.05).The expression levels of PCNA and CD34 in the experimental group were lower than those in the control group (P < 0.05). Conclusion Both the modified closed biopsy technique and needle aspiration biopsy can provide sufficient biopsy tissue for the diagnosis of VX2 transplanted bone tumor in rabbits. At the same time, the improved closed biopsy technique has a certain application value in preventing local metastasis of tumor cells along the puncture channel.
An Efficient, Three-Component Synthesis of Isoindolin-1-One-3-Phosphonates Under Mild and Solvent-Free Conditions and Their Biological Activities
Authors: Jelali Hamida , Nasr Ibrahim S. Al , Koko Waleed S. , Khan Tariq A. , Deniau Eric , Sauthier Mathieu , Hamdi Naceur 
Published: February 2021

Abstract
In this work, the synthesis of isoindolin-1-one-3-phosphonates by a ‘one-pot’ three-component reaction of 2-formylbenzoic acid with primary amines and dimethyl phosphite under solvent and catalyst free-conditions was reported. 1H NMR, 13C NMR, FT-IR and elemental analysis techniques, characterized the obtained compounds. The isoindolin-1-one-3-phosphonates were screened for their antimicrobial activities against bacteria and a fungus (Candida albicans). They were additionally also investigated for their anti-parasitical activities against Leishmania major promastigotes and amastigotes and Toxoplasma gondii in vitro. Cytotoxicity investigations of the isoindolin-1-one-3-phosphonates were led conducted in two human cancer cell lines, MDA-MB-231 and MCF-7and vero cells.
Preparation of Bi2Sr2CaCu2Ox Thin Film By Pulsed Laser Deposition For Optoelectronic Devices Application
Authors: Ismail Raid , Hasan N. , Shaker Suaad S. 
Published: February 2021

Abstract
In this study, we have prepared Bi2Sr2CaCu2Ox (BSCCO) nanostructure films by pulsed laser deposition technique (PLD). The structural and optical properties of nanostructured Bi2Sr2CaCu2Ox film were investigated. X-ray diffraction (XRD) studies of the films prepared at 6.5 and 8 J/cm2 showed that the films are crystalline in nature with orthorhombic phase. Scanning electron microscopy (SEM) investigation confirmed that the deposited film has spherical grains and the mean grain size of the film increased from 150 nm to 250 nm as laser energy density increased from 6.5 to 8 J/cm2. The optical energy gap of the film decreased from 2.24 to 1.7eV when the energy density increased. The optoelectronic properties of the Bi2Sr2CaCu2Ox/Si heterojunction photodetector have been investigated. The photodetectors exhibited rectification properties and the ideality factor of the photodetectors deposited 6.5 and 8 J/cm2 were 2.3 and 4.2, respectively. The on/off ratio of the photodetectors was found to be 761 and 385 for the photodetectors prepared with6.5 and 8 J/cm2, respectively. A responsivity of 514 mA/W at 860 nm was found for the photodetector prepared with 6.5 J/cm2 without using post annealing and/or buffer layer.
Utility of Transesophageal Echocardiography in the Identification and Treatment of Occult Mechanisms of Cerebral Infarction
Authors: Heslin Mark Evan , Thon Jesse M. , Caruso Evan , Romiyo Prasanth , Rana Ankit , Yu Siyuan , Thau Lauren , Rana Ameena , Siegler James E. 
Published: February 2021

Abstract
PurposeTo evaluate the diagnostic utility of TEE in identifying cardiac sources of embolism (CSE) in cryptogenic stroke patients and to determine whether the identification of these CSE results in clinically significant management changes. MethodsA prospective registry of consecutively admitted patients with acute ischemic stroke (1/1/2015-8/10/2020) was retrospectively queried. Patients 18 to 60 years of age with stroke due to mechanisms other than large or small vessel disease, or atrial fibrillation were eligible for inclusion. The primary outcome was any high-risk CSE identified on TEE following unrevealing TTE. Secondary outcomes included a composite of individual CSEs and subsequent management changes. ResultsOf the 2,404 consecutive stroke patients evaluated during the study period, 263 (11%) met inclusion criteria; 103 (39%) were women and the median age was 53 (IQR 46-57). TEE was performed in 108 patients (41%). A high-risk CSE was identified in 36 patients (33%), the majority of which were PFOs (n=29). TEE led to a clinical management change in 14 patients (39%) after identification of a high-risk CSE; 6 underwent PFO closure and 8 had adjustment to their antithrombotic therapy. ConclusionIn our single-center study of cryptogenic stroke patients, the addition of TEE to the comprehensive stroke evaluation led to the identification of a high-risk CSE in one in three patients resulting in significant management changes. Most high-risk CSEs were PFOs, which likely underestimates the likelihood of management change given the publication of successful PFO closure trials in the middle of our study period.
Microwave-Assisted High-Efficiency Degradation of Methyl Orange by using CuFe2O4/CNTs Catalysts and Insight into Degradation Mechanism
Authors: Liu zhifeng , Zhang Wei , Liang Qinghua , Huang Jinhui , Shao Binbin , Liu Yang , Liu Yujie , He Qingyun , Wu Ting , Gong Jilai , Yan Ming , Tang Wangwang 
Published: February 2021

Abstract
Microwave-assisted catalytic oxidation technology has become an effective technology for rapid removal of organic pollutants in wastewater. In this research, the removal of methyl orange from aqueous solution by CuFe2O4 loaded on carbon nanotubes (CuFe2O4/CNTs) under microwave irradiation was studied. The effects of different loadings (1:2, 1:4, 1:8) of CuFe2O4 on the dielectric loss, magnetic loss, dielectric loss factor, magnetic loss factor and reflection loss of composite materials were studied. The results showed that the microwave adsorption performance was improved by loading CuFe2O4 on CNTs. These different composites were further characterized by SEM, FTIR and XRD techniques. In addition, this article also studied the effects of different microwave irradiation time, pH, and ionic factors on the degradation of methyl orange. In particular, the mechanism of methyl orange degradation by composite materials under different pH conditions was also studied in detail. The results show that the removal rate reaches 97.16% with 5 min under the best conditions, and the composite material has good anti-interference performance. This study may provide a new option to degrade organic dye in wastewater treating.
Study of Teenage Students’ Musculoskeletal Health, Teenage Students Training Program: the Application of Intervention Mapping Approach
Authors: NeJhaddadgar Nazila , Tavafian Sedigheh Sadat , Ziapour Arash , Abbas Jaffar , Jamshidi Ahmad Rreza 
Published: February 2021

Abstract
Background: According to the studies conducted, adolescence and its related health issues are of the most significant issues. The purpose of the study was to develop a Musculoskeletal Health intervention-training program using intervention mapping approach (IMA).Methods: The present study was a study protocol where IMA was used as a planning framework for developing musculoskeletal Health intervention-training program. Six intervention mapping steps were completed in the study. As the first step, needs assessment was performed by reviewing the studies, qualitative evaluation and interviews. In the second step, matrix of change objectives was designed. Later on, after designing the program and planning the program implementation, the program evaluation plan was developed.Results: IMA guided us in designing and implementing a control-oriented training program with the participation of the participants along with the definition of outcomes, performance goals and determinants, theoretical methods and practical applications, intervention program, implementation and step by step assessment.Conclusion: Intervention mapping is a participation-based approach to design and implement promotion programs.
BP Network for Predicting the TBM utilization
Authors: Li Ningbo , Zhu Yan , Xiao Qingxia , Xu Xiaobin , Wang Kai , Li Yao , Wang Ruirui , Wang Houtong 
Published: February 2021

Abstract
This paper proposed the idea of combining genetic algorithm (GA) with BP (back propagation) neural network, and establishes the TBM tunneling utilization prediction model based on BPNN-GA. Based on the analysis of rock parameters affecting TBM utilization, the rock mass grade, uniaxial compressive strength UCS and joint spacing DPW are selected as the input parameters for TBM utilization prediction. The TBM utilization prediction model based on BPNN-GA is established. The node number and super parameters of hidden layer are determined by empirical formula. The prediction results of bpnn-ga model are combined with the traditional BPNN model The results show that, compared with the traditional BPNN model, BPNN has been improved under the optimization of genetic algorithm, the prediction accuracy on the test set is increased by about 8.95%, and the mean square error is reduced by about 60%. BPNN-GA model does not rely on specific data sets in prediction, showing good portability and generalization.
Right Ventricular Free wall Longitudinal Strain in Heart Failure with Mid-range and Preserved Ejection Fraction. Application and Prognostic Implications.
Authors: Grados-Saso Daniel , Salvador Juan Manuel , Gracia-Gutiérrez Anyuli , Rubio-Gracia Jorge , Perez-Calvo Juan Ignacio , Lacambra-Blasco Isaac 
Published: February 2021

Abstract
Purpose: Right ventricle plays an important role in heart failure with preserved and mid-range ejection fraction. Right ventricular dysfunction is common and associated with increased morbidity and mortality in this population. Quantification of right ventricular functional parameters by echocardiography is challenging. Right ventricular strain represents a tool that can provide useful information in the assessment of RV function, offering information with potential prognostic implications.Methods: In a cohort of 71 prospectively included patients admitted for an episode of heart failure with mid-range and preserved ejection fraction (LVEF >40%) right ventricular function was evaluated through right ventricular free wall longitudinal strain. Left ventricular global longitudinal strain was also calculated. Relationship with variables such as hospital readmission and cardiovascular mortality was studied. Results: Worse right ventricular free wall longitudinal strain was associated to higher probability of cardiovascular mortality at six months. In a multivariate analysis RV free wall strain remained a predictor of cardiovascular mortality at 6 months. Significant linear correlation (p <0.01) was observed between longitudinal deformation indices of both ventricles. Conclusion In patients with heart failure with preserved and mid-range ejection fraction, impairment of right ventricular free wall strain is common and is related to worse clinical outcome (increased cardiovascular mortality at six months) regardless of other right ventricular functional parameters and left ventricular ejection fraction. Therefore, representing a sensitive non-invasive prognostic indicator in these patients, and could be useful in stratifying the risk of adverse events. RV and LV strain are correlated indicating biventricular involvement of deformation parameters with prognostic significance.
Feasibility of Short Imaging Protocols for [18F]PI-2620 Tau-PET in Progressive Supranuclear Palsy
Authors: Song Mengmeng , Scheifele Maximilian , Barthel Henryk , Eimeren Thilo van , Beyer Leonie , Marek Ken , Eckenweber Florian , Palleis Carla , Kaiser Lena , Finze Anika , Kern Maike , Nitschmann Alexander , Biechele Gloria , Katzdobler Sabrina , Bischof Gerard , Hammes Jochen , Jessen Frank , Saur Dorothee , Schroeter Matthias , Rumpf Jost-Julian , Rullmann Michael , Schildan Andreas , Patt Marianne , Stephens Andrew , Rauchmann Boris , Perneczky Robert , Levin Johannes , Classen Joseph , Neumeier Bernd , Höglinger Günter , Bartenstein Peter , Boening Guido , Ziegler Sibylle , Villemagne Victor , Drzezga Alexander , Seibyl John , Sabri Osama , Brendel Matthias 
Published: February 2021

Abstract
PurposeDynamic 60-minute positron-emission-tomography (PET) imaging with the novel tau radiotracer [18F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [18F]PI-2620 tau-PET imaging of PSP. MethodsThirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [18F]PI-2620 PET was performed by a dynamic 60 minute scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20 minutes p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60 minutes p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier).Results0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen’s d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen’s d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%.ConclusionTruncated and static imaging windows can be used for [18F]PI-2620 PET imaging of PSP. 0-40 minute dynamic scanning offers the best balance between accuracy and economic scanning.
Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells Provide Insights on Parenteral Nutrition Associated Cholestasis in the Immature Liver
Authors: Nghiem-Rao T. Hang , Pfeifer Courtney , Asuncion Michelle , Nord Joshua , Schill Daniel , Pulakanti Kirthi , Patel Shailendra B. , Cirillo Lisa A. , Rao Sridhar 
Published: February 2021

Abstract
Parenteral nutrition-associated cholestasis (PNAC) significantly limits the safety of intravenous parenteral nutrition (PN). Critically ill infants are highly vulnerable to PNAC-related morbidity and mortality, however the impact of hepatic immaturity on PNAC is poorly understood. We examined developmental differences between fetal/infant and adult livers, and used human induced pluripotent stem cell-derived hepatocyte-like cells (iHLC) to gain insights into the contribution of development to altered sterol metabolism and PNAC. We used RNA-sequencing and computational techniques to compare gene expression patterns in human fetal/infant livers, adult liver, and iHLC. We identified distinct gene expression profiles between the human feta/infant livers compared to adult liver, and close resemblance of iHLC to human developing livers. Compared to adult, both developing livers and iHLC had significant downregulation of xenobiotic, bile acid, and fatty acid metabolism; and lower expression of the sterol metabolizing gene ABCG8. When challenged with stigmasterol, a plant sterol found in intravenous soy lipids, lipid accumulation was significantly higher in iHLC compared to adult-derived HepG2 cells. Our findings provide insights into altered bile acid and lipid metabolizing processes in the immature human liver, and support the use of iHLC as a relevant model system of developing liver to study lipid metabolism and PNAC.
The Value of Alveolar Lavage Fluid mNGS in the Peripheral Pulmonary Among Children
Authors: Qiu Kun-yin , Liao Xiong-yu , Fang Jian-pei , Zhou Dun-hua 
Published: February 2021

Abstract
Objectives The aim of this study was to evaluate the value of alveolar lavage fluid mNGS in the diagnosis of peripheral pulmonary infectious lesions among children.Methods Twenty-eight consecutive pediatric patients suspected of pulmonary infections were retrospectively.Result The detection rate of traditional pathogen method was 17.9%, while the detection rate of mNGS was 71.4% (P<0.01,). The smoothing curve also showed that, there is a negative linear correlation between WBC and microbial reads (P<0.05,). Further we found when CRP is less than 60mg/dl, CRP increases with the increase of microbial sequencing reads. With the ROC curves, we demonstrated the different detection methods of alveolar lavage fluid in the diagnosis of peripheral pulmonary infectious lesions.The results showed that mNGS was more sensitive (100%) and specific (90.9%) compared to traditional method (83.3%, 18.2%). The PPV and NPV of mNGS were 100% and 75%. The AUC of mNGS was 95.45%, while the AUC of traditional methods was 50.76%, which was with a significant difference (P<0.001). The PPV and NPV of traditional pathogen detection were 80% and 21.7%. Conclusions Metagenomic NGS analysis can provided fast and precise pathogen detection and identification among children, and WBC and CRP could be used biomarkers of anti-infective efficacy.