bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthotopic bladder substitution: Surgical aspects and optimization of outcomes
Authors: Thakare N. , Lamb B. W. , Biers S. 
Published: September 2021

AbstractObjectivesOrthotopic bladder substitution (OBS) is a management option for urinary diversion in men and women undergoing cystectomy. The aim of the procedure is to provide a functional continent urinary reservoir of adequate capacity, compliance and low pressure. We have provided a narrative review of the existing literature and highlighted areas where improvement and standardization can be recommended.MethodsLiterature search included database search for publications from January 1970 to November 2020, using keywords including OBS, bladder reconstruction, neobladder, radical cystectomy, robotic cystectomy, intracorporeal neobladder, surgical technique, patient selection and outcomes.ResultsDue to various factors including indications, operative technique and risk of complications, OBS is an enormous undertaking and commitment for patients, surgeons and health professionals involved in the care pathway. The main considerations for patient selection, the technical elements of the procedure and the rationale behind these are discussed. Previously considered to be a choice for a select few, the inclusion criteria have expanded over the last decade. Similarly, surgical techniques including the choice and configuration of bowel segments, construction of anastomosis and nerve or organ sparing procedures have evolved over the years. Minimally invasive laparoscopic and robotic assisted surgery has added further perspectives to the existing literature on OBS. Understanding the principles of operative techniques and assessing the best evidence to influence patient management is crucial as it has a major impact on clinical outcomes. Peri‐ and post‐operative care, focused on the prevention of complications and morbidity, affects long‐term functional and oncological outcomes, which ultimately dictates the quality of life.ConclusionsThis concise overview of OBS literature highlights the importance of pre‐operative, peri‐operative, and post‐operative aspects with regards to the optimization of patient care. To achieve the best results, meticulous attention should be paid in all these areas, surgical and multi‐disciplinary. Patient education and counseling, with shared decision making are central to the success of the procedure.
Exploring multidimensional characteristics in cervicogenic headache: Relations between pain processing, lifestyle, and psychosocial factors
Authors: Mingels Sarah , Dankaerts Wim , van Etten Ludo , Bruckers Liesbeth , Granitzer Marita 
Published: September 2021

AbstractObjectiveAlthough multidimensional interventions including physiotherapy, psychology, and education are generally recommended in managing headache, and to prevent chronification, such approach is lacking in cervicogenic headache (CeH). Therefore, exploring CeH within a biopsychosocial framework is deemed an essential first step.MethodsNon‐randomized cross‐sectional design to compare pain processing, lifestyle, and psychosocial characteristics between 18 participants with CeH (CeH group) (40.2 ± 10.9 years) and 18 matched controls (control group) (39.2 ± 13.1 years). Pain processing characteristics included degree of central sensitization (Central Sensitization Inventory), and (extra)‐cephalic pressure pain thresholds (kPa/cm²/s). Lifestyle characteristics included sleep quality (Pittsburgh Sleep Quality Index), physical activity, screen time, and sedentary time (hours a week). Psychosocial characteristics included degree of depression, anxiety and stress (Depression Anxiety Stress Scale‐21), and quality of life (Headache Impact Test‐6).ResultsPain processing characteristics: More (p = .04) participants in the CeH group showed higher degrees of central sensitization compared to the control group. Lower (p < .05) (extra)‐cephalic pressure pain thresholds were revealed in the CeH group compared to the control group for each muscle. Lifestyle and psychosocial characteristics: Compared to the control group, sleep quality and headache‐related quality of life were worse (p < .0001) in the CeH group. Severe to extreme stress was experienced by more participants in the CeH group (p = .02). Further, significant relations between pain processing and (1) lifestyle characteristics and (2) psychosocial characteristics were seen in the CeH group.ConclusionExploring multidimensional characteristics in CeH exposed relations between pain processing, lifestyle, and psychosocial characteristics. These novel findings fill a gap in the current scientific literature, and highlight the need for outcome research targeting lifestyle and psychosocial factors.
Profile, treatment patterns, and influencing factors of anthracycline use in breast cancer patients in China: A nation‐wide multicenter study
Authors: Guo Fengzhu , Yi Zongbi , Wang Wenna , Han Yiqun , Yu Pei , Zhang Su , Ouyang Quchang , Yan Min , Wang Xiaojia , Hu Xichun , Jiang Zefei , Huang Tao , Tong Zhongsheng , Wang Shusen , Yin Yongmei , Li Hui , Yang Runxiang , Yang Huawei , Teng Yuee , Sun Tao , Cai Li , Li Hongyuan , Chen Xi , He Jianjun , Liu Xinlan , Yang Shune , Fan Jinhu , Qiao Youlin , Wang Jiayu , Xu Binghe 
Published: September 2021

AbstractBackgroundAnthracycline‐based chemotherapy (ABC) is one of the standard therapies against breast cancer. However, few guidelines are currently available to optimize the use of ABC. Therefore, the present analysis aimed at determining the profile and treatment patterns of ABC and the association of clinicopathological characteristics with ABC selection.MethodsWe retrospectively analyzed the data of a nation‐wide multicenter epidemiological study, which collected the medical records of breast cancer patients receiving chemotherapy in different settings from seven geographic regions in China (NCT03047889).ResultsIn total, 3393 patients were included, with 2917 treated with ABC. Among them, 553 (89.8%), 2165 (81.7%), and 814 (25.7%) were subjected to ABC as neoadjuvant, adjuvant, and advanced chemotherapy, respectively. The most frequently used regimens were anthracycline‐taxane‐based combinations for neo‐ and adjuvant chemotherapy, along with taxanes and oral fluorouracils for the palliative stages. In the overall cohort, patients aged < 40 or 40‐65 (p < 0.001), in premenopause (p < 0.001), without comorbidities (p = 0.016), with invasive ductal carcinoma (p= 0.001), high lymph node involvement (p < 0.001), in the pTNM stage II, III, or IV versus stage I (p < 0.001), subjected to mastectomy (p < 0.001) or subjected to sentinel lymph node biopsy combined with axillary lymph node dissection (p = 0.044), or with a decreased disease‐free survival (p < 0.001) were more likely to be recommended to ABC.ConclusionTaken together, ABC remained the mainstay of breast cancer treatment, especially in neo and adjuvant therapy. ABC was mainly used as a combination therapy, and the correlation between influencing factors and ABC choice varied during different settings, indicating the preference and different perspectives of medication considered by medical oncologists regarding the use ABC in China.
Fast Pyrolysis of Flax Shive in a Screw‐Type Reactor
Authors: Lugovoy Yury V. , Chalov Kirill V. , Tarabanko Valery E. , Stepacheva Antonina A. , Kosivtsov Yury Yu. 
Published: September 2021

AbstractA novel screw‐type reactor for the fast pyrolysis of agricultural waste (flax shive) is described. A preliminary study on the influence of process parameters on the yield, composition, and properties of pyrolysis products was carried out. Based on the results obtained, the optimal conditions of fast pyrolysis of flax shive particles in terms of feedstock particle size, solid residence time, and process temperature were identified. Considering the construction, the developed reactor seems to be close to the screw fluidized bed and auger reactor and is characterized by a simple design and operation control. Moreover, the proposed reactor can be used for continuous pyrolysis without any significant modification.
All‐Solid‐State Chloride‐Ion Battery with Inorganic Solid Electrolyte
Authors: Sakamoto Ryo , Shirai Nobuaki , Inoishi Atsushi , Okada Shigeto 
Published: September 2021

AbstractChloride‐ion batteries have some attractive properties such as high energy density and low cost. However, they have poor cycle performance because chloride as an active material tends to dissolve into a polar solvent. Herein, an all‐solid‐state chloride‐ion battery is demonstrated with KCl‐doped PbCl2 as a solid electrolyte to suppress the dissolution of chloride. The all‐solid‐state cell with BiCl3 as the cathode had an initial discharge capacity of 187 mAh g−1, which corresponds to 73 % of the theoretical capacity of BiCl3. Moreover, it exhibited better cyclability compared to the previously reported non‐aqueous cell with BiCl3 cathode. During the charge‐discharge process, XRD and XPS analysis confirmed the unique behavior of conversion reaction by Cl− anion, where Bi is produced by discharging and BiCl3 returns by charging.
A Pyrene‐Modified Serinol Nucleic Acid Nanostructure Converts the Chirality of Threoninol Nucleic Acids into Circularly Polarized Luminescence Signals
Authors: Kashida Hiromu , Nishikawa Keiji , Ito Yuka , Murayama Keiji , Hayashi Ichiyo , Kakuta Takahiro , Ogoshi Tomoki , Asanuma Hiroyuki 
Published: September 2021

AbstractHerein is reported a circularly polarized luminescent (CPL) probe that can respond to the chirality of nucleic acids. An achiral nanostructure was prepared by the hybridization of symmetric serinol nucleic acid (SNA) containing pyrene‐modified residues. When chiral oligomers that were complementary to the SNA were added, they induced helicity into the SNA nanowire. Efficient circular dichroism (CD) signal amplification was observed when pyrene was attached to uracil bases through a rigid alkynyl linker. Both CPL and CD signals were observed; they depended on the chirality of the added acyclic threoninol nucleic acid (aTNA) oligomer. This system can be used to convert the chirality of chiral biomolecules into chiroptical signals.
Cross‐Coupling through Ag(I)/Ag(III) Redox Manifold
Authors: Demonti Luca , Saffon‐Merceron Nathalie , Mézailles Nicolas , Nebra Noel 
Published: September 2021

AbstractIn ample variety of transformations, the presence of silver as an additive or co‐catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross‐coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e− redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through AgI/AgIII redox catalysis (i. e. CEL coupling), namely: i) easy AgI/AgIII 2e− oxidation mediated by air; ii) bpy/phen ligation to AgIII; iii) boron‐to‐AgIII aryl transfer; and iv) ulterior reductive elimination of benzotrifluorides from an [aryl‐AgIII‐CF3] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]+[AgIII(CF3)4]− (K‐1), [(bpy)AgIII(CF3)3] (2) and [(phen)AgIII(CF3)3] (3), is described. The utility of 3 in cross‐coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [AgIII(aryl)(CF3)3]− intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross‐coupling by itself.
ChemiTEM – Transmission Electron Microscopy Optimized for Chemistry and Material Science
Authors: Hetaba Walid , Imlau Robert , Duarte‐Correa Liseth , Lamoth Maximilian , Kujawa Stephan , Lunkenbein Thomas 
Published: September 2021

AbstractInvited for this month's cover is the group of Walid Hetaba and Thomas Lunkenbein at the Max‐Planck‐Institutes in Berlin and Mülheim (Germany). The cover picture shows the ChemiTEM acquisition workflow in a tablet app in front of a transmission electron microscope (TEM). Additionally, the results obtained by a TEM‐expert and by non‐expert TEM users are shown left and right of the microscope, respectively. It symbolises that using the ChemiTEM workflows, non‐expert TEM users can proficiently use a TEM and generate data which is of comparable quality as the data obtained by a TEM‐expert. Furthermore, the training time of the users is reduced and electron microscopical investigations can be performed with much higher efficiency. ChemiTEM extends the TEM user base and makes this instrument a versatile standard lab tool. Read the full text of their Full Paper at 10.1002/cmtd.202100001.
Changes in tongue pressure and dysphagia at oral cancer patients by palatal augmentation prosthesis
Authors: Kuniyuki Izumita , Hisaoka Takuma , Ikeda Ryoukichi , Suzuki Jun , Sato Naoko , Tagaino Ryo , Kambayashi Tomonori , Hirano‐Kawamoto Ai , Ohta Jun , Ohkoshi Akira , Ishii Ryo , Shitraishi Naru , Kato Kengo , Koyama Shigeto , Sasaki Keiichi , Katori Yukio 
Published: September 2021

AbstractBackgroundThe palatal augmentation prosthesis (PAP) is an intraoral prosthesis used in the treatment of dysphagia.AimThe objective of the study is to examine the effect of PAP using tongue pressure and the Videofluoroscopic Dysphagia Scale (VDS) to understand the precise mechanism for improvement in swallowing function with PAP for oral cancer at retrospective survey.Methods and resultsFifteen patients were provided PAPs. Tongue pressure and VDS were evaluated with and without PAP. After intervention with PAP, tongue pressure significantly increased as compared to when without PAP (p < .05). The total mean VDS score with PAP was found to have significantly improved (p < .05). The mean VDS score of the oral phase also significantly improved with the PAP compared to without the PAP group (p < .05). Significant differences (p < .01) were found in each category, such as tongue to palate contact and pyriform sinus residue.ConclusionPAP can improve tongue pressure, tongue to palate contact, and pyriform sinus residue.
CO2 Capture, Separation and Reduction on Boron‐Doped MoS2, MoSe2 and Heterostructures with Different Doping Densities: A Theoretical Study
Authors: Qu Mengnan , Xu Shaohua , Du Aijun , Zhao Chongjun , Sun Qiao 
Published: September 2021

AbstractDesigning high‐performance materials for CO2 capture and conversion is of great significance to reduce the greenhouse effect and alleviate the energy crisis. The strategy of doping is widely used to improve activity and selectivity of the materials. However, it is unclear how the doping densities influence the materials’ properties. Herein, we investigated the mechanism of CO2 capture, separation and conversion on MoS2, MoSe2 and Janus MoSSe monolayers with different boron doping levels using density functional theory (DFT) simulations. The results indicate that CO2, H2 and CH4 bind weakly to the monolayers without and with single‐atom boron doping, rendering these materials unsuitable for CO2 capture from gas mixtures. In contrast, CO2 binds strongly to monolayers doped with diatomic boron, whereas H2 and CH4 can only form weak interactions with these surfaces. Thus, the monolayers doped with diatomic boron can efficiently capture and separate CO2 from such gas mixtures. The electronic structure analysis demonstrates that monolayers doped with diatomic doped are more prone to donating electrons to CO2 than those with single‐atom boron doped, leading to activation of CO2. The results further indicate that CO2 can be converted to CH4 on diatomic boron doped catalysts, and MoSSe is the most efficient of the surfaces studied for CO2 capture, separation and conversion. In summary, the study provides evidence for the doping density is vital to design materials with particular functions.
FPGA implementation of high‐speed tunable IIR band pass notch filter for identification of hot‐spots in protein
Authors: Pathak Vikas , Nanda Satyasai Jagannath , Joshi Amit Mahesh , Sahu Sitanshu Sekhar 
Published: September 2021

SummaryLocalization of hot spots in a protein sequence is an important problem for understanding complex 3D structure of amino acid sequence (due to which biological functionality of protein is performed by their mutual interactions). Several digital signal processing (DSP) techniques like digital filtering, wavelet, and Fourier transforms have been used for finding the hot‐spot locations. Fast processing of these longer protein sequences is desirable. Field Programmable Gate Array (FPGA) implementation of Infinite Impulse Response (IIR) band pass notch (BPN) digital filter (tuned automatically by characteristics frequency of protein family) is carried out in this paper for further speed‐up of this protein analysis process. Performance of proposed filter system (implemented on Zynq series Zybo board FPGA) is further improved using retiming, which has significantly increased the maximum clock frequency from 34.304 to 54.812 MHz. Simulation of both MATLAB and FPGA hardware implementation for BPN IIR filter is executed on 10 protein functional groups. The simulation results predict the same hot‐spots locations as mentioned in ASEdb data base, but the Hardware BPN IIR filter (proposed in this paper) is 190 to 278 times faster as compared to its MATLAB counterpart. Some additional new hot‐spot locations (not mentioned in ASEdb data base) have been determined by our proposed hardware filter, which can be the probable hot‐spots for newly identified proteins.
A survey of 5G millimeter wave, massive multiple‐input multiple‐output, and vehicle‐to‐vehicle channel measurements and models
Authors: Eldowek Basim Mohammed , Bauomy Nariman Abd El‐Salam , El‐Rabaie El‐Sayed M. , Abd El‐Atty Saied M. , Abd El‐Samie Fathi E. 
Published: September 2021

SummaryThere is no doubt that the world evolves nowadays in the digital communications era. This opens the horizon to research and investment in new promising technologies like 5G and beyond cellular networks that are able to increase the subscribers' data rates in all communication systems. The aim of 5G and beyond cellular networks is to provide anywhere and anytime connectivity. By combining the enormous available bandwidth in millimeter wave (mmWave) frequencies with high multiplexing gains achieved by large antenna arrays in multiple‐input multiple‐output (MIMO) systems, these technologies can significantly improve network throughput, increase network power, boost energy and spectral efficiency, and enhance network coverage. Furthermore, ultra‐reliable vehicular communication and high capacity would be essential features of communication networks beyond 5G. Fortunately, when vehicles are moving on the road and communicating with each other, the vehicular communication issue becomes more challenging. Among the several new technologies expected to play significant roles in the 5G and beyond systems, this paper focused on summarizing the state‐of‐the‐art mmWave, vehicle‐to‐vehicle (V2V), and massive MIMO measurements and models. We introduce a detailed overview of each of the three technologies individually. Besides, novel taxonomies for the 5G channel measurements, objectives, and model types are provided. We expect that mmWave‐based massive MIMO technology enables real‐time channel estimation and ultra‐precise beamforming, and thus enables better service coverage. Finally, challenges and future research directions for 5G channel measurements and models are presented.
Impact of hybridized rider optimization with cuckoo search algorithm on optimal VANET routing
Authors: Gnanasekar Tony Santhosh , Samiappan Dhandapani 
Published: September 2021

SummaryVANET routing is a serious concern due to some of the limitations in terms of routing costs. More research has already worked on VANET routing strategies for enhancing the performance of the network. However, optimal route selection is a tedious or complex issue in this scenario. To cope with this issue, this research work attempts to introduce a new VANET routing model that considers certain network quality measures such as congestion, travel, collision, and QoS awareness cost. A new cost model is designed based on the given constraints. Along with this, the fuzzification of the QoS factor is considered along with the total routing cost. This work determines the optimal route selection with minimized routing cost by employing a novel optimization algorithm called Rider Integrated Cuckoo Search (RI‐CS) that hybridizes the concept of Rider Optimization Algorithm (ROA) and Cuckoo Search (CS). Finally, the performance of the proposed RI‐CS is analyzed against the conventional models like Particle Swarm Optimization (PSO), Firefly algorithm (FA), Grey Wolf Optimizer (GWO), Whale Optimization Algorithm (WAO), ROA, CS, Mean Computing Jaya Algorithm (MC‐JA), and Grey Updated Butterfly Operator (GU‐BO) in terms of certain cost analysis.
Permanent endoscopic transpapillary gallbladder drainage using a novel spiral stent (IYO‐stent)
Authors: Takano Yuichi , Noda Jun , Yamawaki Masataka , Azami Tetsushi , Kobayashi Takahiro , Niiya Fumitaka , Maruoka Naotaka , Yamagami Tatsuya , Nagahama Masatsugu 
Published: September 2021

AbstractBackground and aimEndoscopic transpapillary gallbladder drainage (ETGBD) is widely performed. However, there is no consensus on the appropriate diameter, length, and shape of the stent that should be used in this procedure. In addition, there are limited data on the outcomes of permanent ETGBD. In our facility, a stent with a novel spiral structure (IYO‐stent) is permanently placed in patients with acute cholecystitis who are not indicated for surgery. This study examined the efficacy and safety of the IYO‐stent in cases of permanent ETGBD.MethodsWe retrospectively examined patients who underwent permanent ETGBD using the IYO‐stent from April 2018 to December 2020.ResultsEleven patients were included in this study. The technical success and the clinical success rate were 91%. One patient had a post‐procedure adverse event (post‐endoscopic sphincterotomy bleeding). Within the median observation period of 312 days (range: 109–742), late adverse events, including cholangitis (n = 1) and incomplete stent migration (n = 1), were observed. However, none of the patients experienced cholecystitis relapse.ConclusionPermanent ETGBD with IYO‐stent is an effective treatment for the patients with acute cholecystitis who are not indicated for surgery.
Psoriasis comorbidities and clinical implications when using biologics
Authors: Kang Julianna S. , Balogh Esther A. , Feldman Steven R. 
Published: September 2021

AbstractBackgroundPsoriasis is a cutaneous inflammatory disorder with associated comorbidities which can influence treatment options. Biologics are immune‐modifying agents that can improve or worsen pre‐existing psoriasis comorbidities. The risks associated with a particular biologic agent and its effects on a comorbidity can guide treatment decisions and direct further workup to screen for markers of these comorbidities.MethodsA literature search was performed to develop treatment recommendations for psoriasis patients in the background of common comorbidities when considering biologic agents.ResultsPsoriatic arthritis, inflammatory bowel disease, metabolic syndrome, nonalcoholic fatty liver disease, depression, and malignancies are comorbidities associated with psoriasis that can be affected by certain biologic agents.ConclusionConsiderations to make when treating a patient with psoriasis include the severity of disease, the presence of comorbidities, and symptomology that can interact with biologic agents.