bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrapulmonary percussive ventilation via Mini-Trach II in critical care: a case report
Authors: Niisato Emina , Hiramoto Yoshiyuki , Yamada Hitoshi , Matsumiya Naoki 
Published: August 2021

Abstract
Background
Intrapulmonary percussive ventilation (IPV) facilitates the mobilization and clearance of bronchial secretions. Cricothyroidotomy using a Mini-Trach II device is a minimally invasive method used for secretion clearance. To our knowledge, there are no previous reports regarding IPV combined with Mini-Trach II.

Case presentation
An 82-year-old man underwent controlled mechanical ventilation and IPV via an endotracheal tube to treat atelectasis following emergency surgical repair of a traumatic diaphragm laceration. He underwent cricothyroidotomy using Mini-Trach II for ensuring airway management after extubation. On resumption, IPV through a mouthpiece or face mask was unsuccessful owing to air leakage from his mouth. However, IPV via the already inserted Mini-Trach II could deliver the percussion flow and led to a marked improvement in his condition.

Conclusion
This experience indicates that Mini-Trach II is beneficial as a minimally invasive interface for IPV that can deliver percussion flow efficiently.
A narrative review on environmental impacts of cannabis cultivation
Authors: Zheng Zhonghua , Fiddes Kelsey , Yang Liangcheng 
Published: August 2021

AbstractInterest in growing cannabis for medical and recreational purposes is increasing worldwide. This study reviews the environmental impacts of cannabis cultivation. Results show that both indoor and outdoor cannabis growing is water-intensive. The high water demand leads to water pollution and diversion, which could negatively affect the ecosystem. Studies found out that cannabis plants emit a significant amount of biogenic volatile organic compounds, which could cause indoor air quality issues. Indoor cannabis cultivation is energy-consuming, mainly due to heating, ventilation, air conditioning, and lighting. Energy consumption leads to greenhouse gas emissions. Cannabis cultivation could directly contribute to soil erosion. Meanwhile, cannabis plants have the ability to absorb and store heavy metals. It is envisioned that technologies such as precision irrigation could reduce water use, and application of tools such as life cycle analysis would advance understanding of the environmental impacts of cannabis cultivation.
Prediction of arch perimeter based on arch width as a guide for diagnosis and treatment planning
Authors: Elhiny Omnia A. , Elyazied Mohammed Abou , Salem Ghada A. 
Published: August 2021

Abstract
Background
The choice between extraction and expansion treatment is an endless debate in orthodontics. Ethnic and secular variations showed that there was a change in arch perimeter over the last 50 years. Accordingly, the purpose of this study was to investigate the relation between the arch perimeter and the intercanine and intermolar widths in normal occlusion. Also, to design regression equations for the prediction of the arch perimeter based on arch width, in a sample of the Egyptian population. The images of 340 cast pairs for 11 to 13-year-old patients were traced using TracerNet. Intercanine width, intermolar width and arch perimeter were measured, statistical analysis was performed and regression equations for both arches were formulated.

Results
There was a positive correlation between the lower arch AP, ICW and IMW and between the upper arch AP and ICW. Lower arch perimeter = 0.536 I33 + 71.642, lower arch perimeter = 0.828 l66 + 58.604 and upper arch perimeter = 1.988 U33 + 30.492 were the significant derived equations.

Conclusions
The formulation of regression equations offers a tool for the prediction of arch perimeter or arch width that can act as a guide in diagnosis and treatment planning.
E2112: Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Hormone Receptor–Positive Advanced Breast Cancer. A Trial of the ECOG-ACRIN Cancer Research Group
Authors: Connolly Roisin M. , Zhao Fengmin , Miller Kathy D. , Lee Min-Jung , Piekarz Richard L. , Smith Karen L. , Brown-Glaberman Ursa A. , Winn Jennifer S. , Faller Bryan A. , Onitilo Adedayo A. , Burkard Mark E. , Budd George T. , Levine Ellis G. , Royce Melanie E. , Kaufman Peter A. , Thomas Alexandra , Trepel Jane B. , Wolff Antonio C. , Sparano Joseph A. 
Published: August 2021

PURPOSE Endocrine therapy resistance in advanced breast cancer remains a significant clinical problem that may be overcome with the use of histone deacetylase inhibitors such as entinostat. The ENCORE301 phase II study reported improvement in progression-free survival (PFS) and overall survival (OS) with the addition of entinostat to the steroidal aromatase inhibitor (AI) exemestane in advanced hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancer. PATIENTS AND METHODS E2112 is a multicenter, randomized, double-blind, placebo-controlled phase III study that enrolled men or women with advanced HR-positive, HER2-negative breast cancer whose disease progressed after nonsteroidal AI. Participants were randomly assigned to exemestane 25 mg by mouth once daily and entinostat (EE) or placebo (EP) 5 mg by mouth once weekly. Primary end points were PFS by central review and OS. Secondary end points included safety, objective response rate, and lysine acetylation change in peripheral blood mononuclear cells between baseline and cycle 1 day 15. RESULTS Six hundred eight patients were randomly assigned during March 2014-October 2018. Median age was 63 years (range 29-91), 60% had visceral disease, and 84% had progressed after nonsteroidal AI in metastatic setting. Previous treatments included chemotherapy (60%), fulvestrant (30%), and cyclin-dependent kinase inhibitor (35%). Most common grade 3 and 4 adverse events in the EE arm included neutropenia (20%), hypophosphatemia (14%), anemia (8%), leukopenia (6%), fatigue (4%), diarrhea (4%), and thrombocytopenia (3%). Median PFS was 3.3 months (EE) versus 3.1 months (EP; hazard ratio = 0.87; 95% CI, 0.67 to 1.13; P = .30). Median OS was 23.4 months (EE) versus 21.7 months (EP; hazard ratio = 0.99; 95% CI, 0.82 to 1.21; P = .94). Objective response rate was 5.8% (EE) and 5.6% (EP). Pharmacodynamic analysis confirmed target inhibition in entinostat-treated patients. CONCLUSION The combination of exemestane and entinostat did not improve survival in AI-resistant advanced HR-positive, HER2-negative breast cancer.
Using Step Counts to Prescribe Physical Activity: What Is the Optimal Dose?
Authors: Washburn Benjamin D. , Ihm Joseph M. 
Published: August 2021

Abstract
An activity goal of 10,000 steps per day is widely known but was not initially developed based on scientific evidence. The last several years have seen an increase in both the availability of consumer-based step counting devices and research examining the link between daily step counts and various health outcomes. Daily step counts are an intuitive metric of physical activity and are useful for goal-setting and motivating behavioral change. This article reviews the current evidence for daily step counts as related to common health conditions to determine activity goals to prescribe to patients, and also discusses factors to consider when counseling patients on physical activity.
The need to reassess single-cell RNA sequencing datasets: more is not always better
Authors: Ascensión Alex M. , Araúzo-Bravo Marcos J. , Izeta Ander 
Published: August 2021

Background: The advent of single-cell RNA sequencing (scRNAseq) and additional single-cell omics technologies have provided scientists with unprecedented tools to explore biology at cellular resolution. However, reaching an appropriate number of good quality reads per cell and reasonable numbers of cells within each of the populations of interest are key to infer conclusions from otherwise limited analyses. For these reasons, scRNAseq studies are constantly increasing the number of cells analysed and the granularity of the resultant transcriptomics analyses. Methods: We aimed to identify previously described fibroblast subpopulations in healthy adult human skin by using the largest dataset published to date (528,253 sequenced cells) and an unsupervised population-matching algorithm. Results: Our reanalysis of this landmark resource demonstrates that a substantial proportion of cell transcriptomic signatures may be biased by cellular stress and response to hypoxic conditions. Conclusions: We postulate that the ”more is better” approach, currently prevalent in the scientific community, might undermine the extent of the analysis, possibly due to long computational processing times inherent to large datasets.
New faunistic records of cockroaches (Insecta: Blattodea) from Oman
Authors: Al-Jahdhami Ali , Al-Shukaili Sheikha 
Published: August 2021

The knowledge of Blattodea from Oman is still incipient. One species of cockroaches are reported from Oman so far and this indicates the large blank in our knowledge in this order when compared to recorded species from other neighboring countries in the Arabian Peninsula. Blattodea have been collected at various localities in Sultanate of Oman with different sampling artifacts. The present communication records five species of cockroaches from Oman, namely Blattella biligata (Walker, 1868), Heterogamisca Bey-Bienko, 1950, Pycnoscelus surinamensis (Linnaeus, 1758), Tivia fusca Bohn, 2008 from northern Oman and Neostylopyga rhombifolia (Stoll, 1813) from southern Oman.
Anticipating, experiencing and overcoming challenges in clinical academic training
Authors: Trusson Diane , Rowley Emma , Barratt Jonathan 
Published: August 2021

Background/Aims This article builds on studies that have reported on the challenges of pursuing a clinical academic career. It aims to explore the perceived challenges that clinical academic trainees experience, and the ways in which they overcome them. Methods Data were collected from clinical academic trainees via an online survey and semi-structured interviews, then thematic analysis was performed. Results The trainees experienced challenges relating to balancing and progressing a clinical academic career. They sought to overcome these through self-efficacy and by drawing on the support of peers, supervisors and mentors. Conclusions Clinical academic trainees experience significant challenges as they strive to develop careers in academic medicine. They draw on their own resources and the support of others to help them to overcome these challenges. They also often act to advocate, advise and support other aspiring clinical academics.
Automatic Knot Detection in Coarse-Resolution Cone-Beam Computed Tomography Images of Softwood Logs
Authors: Fredriksson Magnus , Cool Julie , Avramidis Stavros 
Published: August 2021

Abstract
X-ray computed tomography (CT) scanning of sawmill logs is associated with costly and complex machines. An alternative scanning solution was developed, but its data have not been evaluated regarding detection of internal features. In this exploratory study, a knot detection algorithm was applied to images of four logs to evaluate its performance in terms of knot position and size. The results were a detection rate of 67 percent, accurate position, and inaccurate size. Although the sample size was small, it was concluded that automatic knot detection in coarse resolution CT images of softwoods is feasible, albeit for knots of sufficient size.
Dual-output filter-free microwave photonic single sideband up-converter with high mixing spur suppression
Authors: Ding Jiewen , Zhu Dan , Zhang Bowen , Pan Shilong 
Published: August 2021

A dual-output filter-free microwave photonic single sideband (SSB) up-converter with the mixing spurs highly suppressed is proposed and experimentally demonstrated. By introducing the balanced Hartley structure using a 90° optical hybrid, the lower sideband (LSB) and upper sideband (USB) up-converted RF signals can be generated simultaneously and output separately, with no need of either optical or electrical filtering. The structure avoids the special requirement with the optical modulation format of the local oscillator (LO) signal. The intermediate frequency signal is modulated with the optical carrier suppressed -SSB modulation format. The undesired optical components are highly suppressed. In this way, the high sideband and LO leakage suppression ratios of the SSB up-converter are guaranteed. The dual-output SSB up-conversion is experimentally achieved within the working frequency range of 10–30 GHz. The undesired sideband and LO leakage suppression ratios are larger than 67 dB for the whole frequency range. The spurious-free dynamic range of larger than

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has also been achieved experimentally for both the LSB and USB up-conversion conditions.
The effect of risk at birth on breastfeeding duration and exclusivity: A cohort study at a Brazilian referral center for high-risk neonates and infants
Authors: Silva Maíra Domingues Bernardes , de Oliveira Raquel de Vasconcellos Carvalhaes , Alves Davi da Silveira Barroso , Melo Enirtes Caetano Prates 
Published: August 2021

Background and aim
Both breastfeeding and the use of human milk are strategies that provide better conformation to health throughout an individual’s life and bring countless short- and long- term benefits, which are well established in the scientific literature. For at-risk newborns (NBs), these strategies are crucial interventions to enable neonatal survival with better quality of life due to the distinctive and complex composition of human milk, which serves as personalized food-medicine-protection. However, there is limited knowledge about breastfeeding practices in high-risk NBs. The aim was to estimate the duration of EBF and to investigate the effect of risk at birth on EBF discontinuity in the first six months of life’.

Methods
This cohort study included 1,003 NBs from a high-risk referral center, followed up from birth to the sixth month of life, between 2017 and 2018. Correspondence and cluster analysis was used to identify neonatal risk clusters as the main exposure. The object of interest was the time until EBF discontinuity. The Kaplan-Meier methods and the Cox proportional hazards model were used to estimate the hazard ratio and 95% confidence intervals.

Results
The prevalence and median duration of EBF decreased proportionally in the three groups. The multiple model revealed a gradient in EBF discontinuity, which was 40% higher in risk group 1 and 111% higher in risk group 2 compared to healthy full-term NBs. Additionally, EBF during hospitalization predicted a longer median duration of this practice for high-risk NBs.

Conclusion
This study confirms a high proportion of high-risk NBs who have EBF discontinued before six months of life. The risk of EBF discontinuity is higher in risk groups, with a gradual effect even when adjusted by several factors. Effective interventions are needed to promote, protect, and support breastfeeding in different profiles of risk-at-birth groups.
Endoscopic transsphenoidal surgery for resection of pituitary macroadenoma: A retrospective study
Authors: Yan Jiun-Lin , Chang Chen-Nen , Chen Pin-Yuan 
Published: August 2021

Background
The endoscopic transsphenoidal approach is an efficient minimally invasive procedure for removal of pituitary tumors that can be accomplished through a one-hand or two-hand approach. The one-hand procedure through one nostril is more intuitive for surgeons, but maneuvering the instruments can be restrictive. The two-hand procedure using a one-and-half nostril approach provides more precise manipulation. This study aimed to compare the surgical outcomes of one-hand/mono-nostril and two-hand/one-and-half nostril surgeries for resection of large pituitary tumors by a single neurosurgeon.

Materials and methods
The surgical data of 78 consecutive cases with pituitary macroadenoma (diameter >1 cm) were reviewed retrospectively. Altogether, 30 cases received one-hand/mono-nostril surgery, while 48 cases received two-hand/one-and-half nostril surgery. Postoperative outcomes of the two operations were compared.

Results
The operative time, hospital stay, residual rate of pituitary macroadenoma, visual field, surgical complications, and re-operative rates were slightly improved in the two-hand/one-and-half nostril surgery group compared with that in the one-hand/mono-nostril surgery group (all p>0.05). However, postoperative hypopituitarism was less frequent (1/48; 2.0%) with the two-hand/one-and-half nostril approach than with the mono-nostril approach (p = 0.004). Similar surgical outcomes were found in all patients with either small or large pituitary tumors, except that the difference in postoperative improvement in visual field change reached statistical significance (p = 0.044).

Conclusion
A single-surgeon endoscopic endonasal transsphenoidal surgery with two-hand/one-and-half nostril approach is an effective and safe procedure for removal of large pituitary tumors.
Substance use disorders and suicidality in youth: A systematic review and meta-analysis with a focus on the direction of the association
Authors: Rioux Charlie , Huet Anne-Sophie , Castellanos-Ryan Natalie , Fortier Laurianne , Le Blanc Myriam , Hamaoui Stéphanie , Geoffroy Marie-Claude , Renaud Johanne , Séguin Jean R. 
Published: August 2021

BackgroundReviews and meta-analyses suggest that substance use and suicidality (i.e., suicidal ideations and attempts) are associated in youth, but the direction of this association remains unclear. Theoretically, the secondary psychiatric disorder hypothesis (SPDH) posits that substance use leads to suicidality, while the secondary substance use disorder hypothesis (SSUDH) posits that suicidality leads to substance use. To clarify these associations, this meta-analysis systematically reviewed studies that examined the prospective associations between SUDs and suicidality in youth (age 25 and younger) and compared results according to the direction of the association.MethodsWeb of Science, Embase, PsycINFO, PubMed, Medline and ProQuest Dissertations & Theses Global were searched from inception to March 8, 2020, and 55 effect sizes from 23 samples were included and analyzed using a three-level meta-analysis.ResultsSUDs significantly predicted subsequent suicidality (OR = 2.16, 95%CI 1.57–2.97), suicidality significantly predicted subsequent SUDs (OR = 2.16, 95%CI 1.53–3.04), and these effect sizes did not differ (p = 0.49).ConclusionsConsidering that 65% of reviewed studies only examined the SPDH, this review highlights that more attention should be given to the SSUDH, and that studies should examine bidirectional associations between SUDs and suicidality across time. Clinically, because SUDs and suicidality were found to influence each other, results suggest that mental health and SUDs should ideally be detected and treated early, and that co-occurring disorders should be assessed and treated concomitantly.
Classical poetic motifs as alchemical metaphors in the Shudhūr al-dhahab and its commentaries
Authors: Todd Richard 
Published: August 2021

Abstract
Traditionally prized as much for its poetic artistry as its didactic content, Ibn Arfaʿ Raʾs’s (fl. twelfth century) dīwān of alchemical verse, the Shudhūr al-dhahab (Shards of Gold), is one of the most important and influential works in the literary canon of Arabic alchemy. Drawing on commentaries by both Ibn Arfaʿ Raʾs himself and Aydamir al-Jildakī (d. 743/1342 [?]), the present article explores a core feature of Ibn Arfaʿ Raʾs’s allegorical style – one that appears to have captured the attention of his medieval readership – namely his novel use of stock poetic motifs as metaphors for alchemical processes and substances. As well as focusing on the commentators’ theoretical interpretations, the article situates Ibn Arfaʿ Raʾs’s deliberate appropriation of pre-Islamic and Nuwāsian motifs in its broader literary context, noting the extent to which it foreshadows similar techniques in the poetic allegories of the thirteenth-century Sufi poets, Ibn ʿArabī and Ibn al-Fāriḍ.
Quintuple band circular monopole antenna with innovative 3-D printed PLA substrate for wireless applications
Authors: Ahmed Ashraf E. , Ali Wael A.E. , Das Sudipta 
Published: August 2021

Abstract
In this paper, a circular antenna with a 3-D printed substrate is introduced to achieve a multiband behavior. The circular antenna is matched using a key-shaped stub located on the perimeter of the designed antenna. The 3-DP circular antenna adopted the apollonian gasket technique to perform the multi-circular cuttings in the Polylactic Acid (PLA) substrate as an innovative technique to obtain quintuple bands. The proposed antenna is designed to operate for Bluetooth, WLAN, WiMAX, and other wireless applications in S-band and C-band. The designed antenna has a compact size of 61.1 × 43.6 × 1 mm3. The prototype of the suggested 3-D printed antenna is fabricated and measured to confirm the simulation results. A good agreement is evident between simulation and experimental results which validates the design concept.
Sound absorption characteristics of three species (binuang, balsa and paulownia) of low density hardwood
Authors: Jang Eun-Suk , Kang Chun-Won 
Published: August 2021

AbstractIn this study, the sound absorption coefficient of three low density hardwoods – binuang, balsa and paulownia – were investigated. Their gas permeability and pore size were measured, and their pore shapes were classified into through pore, blind pored, and closed pore, as specified by the International Union of Pure and Applied Chemistry (IUPAC). Among the three species, obvious that paulownia had lowest sound absorption when the two of others showed higher sound absorption. Although paulownia is a high porosity wood, most of its vessels are blocked by tyloses; it is therefore difficult for sound waves to enter its pores, which results in poor sound absorption performance. This study showed that the higher the through pore porosity, the higher was the gas permeability, which led to improvement of the sound absorption performance. It was also found that the sound absorption coefficient of the three species woods increased at low frequencies as the size of an air cavity between the specimens and tube’s wall increased.