bluuebunny/crossref_metadata_2025_split huggingface dataset:
ALIH KODE DAN CAMPUR KODE PADA PERISTIWA TUTUR KAMPANYE PEMILIHAN KEPALA DESA DI DESA AGUNG MULYA KABUPATEN KOTAWARINGIN TIMUR
Authors: Perdana Indra 
Published: January 2021

Abstract Code Switching and Code Mixing in The Village Chief Election CampaignAgung Mulya Village, East Kotawaringin Regency. This research describe codeswitching and code mixing along with its causal factors in the event of the villagechief election campaign in Agung Mulya Village, East Kotawaringin Regency andits implications. This study uses a qualitative approach. The subjects of this studywere prospective village heads and communities who held conversations inelection campaign activities. Data collection uses the refer, record and writingmethod. Data were analyzed by descriptive method with coding steps andclassification. The validity of the data is obtained through semantic validity test,and reliability using intra-rater and inter-rater. The results of this study can beconcluded related to the forms of code switching (internal) including, interlanguagecodeswitching,andcodeswitchingbetweenvariousandmixedcodeintoandmixed code out. Factors that cause code interference include; (a) limitedlanguage mastery, (b) speaker habits, and (c) facilitating speech intent andpurpose. Key words: code switching and code mixing, campaignAbstrakAlih Kode Dan Campur Kode Pada Peristiwa Tutur Kampanye PemilihanKepala Desa Di Desa Agung Mulya Kabupaten Kotawaringin Timur. Penelitianini bertujuan mendeskripsikan alih kode dan campur kode beserta faktor-faktorpenyebabnya pada peristiwa tutur kampanye pemilihan kepala desa di Desa AgungMulya Kabupaten Kotawaringin Timur serta implikasinya. Penelitian inimenggunakan pendekatan kualitatif. Subjek penelitian ini adalah calon kepaladesa dan masyarakat yang melakukan percakapan dalam kegiatan kampanyepemilihan kepala desa. Pengumpulan data menggunakan metode simak, rekam dancatat. Data dianalisis dengan metode deskriptif dengan langkah pengkodean danpengklasifikasian. Keabsahan data diperoleh melalui uji validitas sematik, danreliabilitas menggunakan intra-rater dan inter-rater. Hasil penelitian ini dapatdisimpulkan terkait dengan bentuk-bentuk alih kode (internal) meliputi, alih kode antar bahasa, dan alih kode antar ragam dan Campur kode ke dalam dan campurkode ke luar. Faktor-faktor penyebab terjadinya campur kode meliputi; (a)keterbatasan penguasaan bahasa, (b) kebiasaan penutur, dan (c) memudahkanmaksud dan tujuan tutur. Kata-kata kunci: campur kode, alih kode, kampanye
PENANAMAN SIKAP CINTA TANAH AIR MELALUI KAJIAN EKOLOGI SASTRA DALAM NOVEL BERSETTING DI KALIMANTAN SELATAN
Authors: Normuliati Sri , Hamidah Jamiatul , Anwari M. Ridha 
Published: January 2021

Penelitian ini bertujuan untuk mengetahui hubungan sastra dengan lingkungan melalui kajian ekologi sastra, sehingga dapat diperoleh nilai-nilai kehidupan dalam karya sastra. Salah satunya adalah penanaman sikap cinta tanah air. Penelitian ini menggunakan pendekatan deskriptif. Data yang dijadikan objek dalam penelitian ini berupa kata, kalimat, dan dialog yang terdapat dalam novel bersetting di Kalimantan Selatan. Teknik pengumpulan data yang dilakukan dalam penelitian adalah dengan melakukan pembacaan terhadap novel yang bersetting di Kalimantan Selatan, mendata semua kata-kata, frasa, kalimat, dialog dan paragraf yang berhubungan lingkungan yang terdapat dalam novel bersetting di Kalimantan Selatan, setelah data terkumpul, data akan dianalisis dan ditarik kesimpulan. Hasil dari penelitian ini memperlihatkan keindahan alam dan kerusakan alam yang digambarkan dalam novel. Keindahan alam loksado yang hendaknya selalu dijaga dan kerusakan hutan yang diakibatkan oleh aktivitas tambang illegal memberikan dampak bagi alam dan bagi masyarakat sekitar. Melalui gambaran tersebut memberikan pemahaman kepada pembaca agar memiliki sikap cinta tanah air yang dapat dilakukan dengan mencegah kerusakan hutan, menjaga keberadaan hutan-hutan hijau, dan mempertahankan kebudayaan. Kata kunci: ekologi sastra, novel, cinta tanah air
IMPLEMENTASI PROGRAM ADIWIYATA DALAM MEMBENTUK SIKAP KEPEDULIAN SISWA TERHADAP LINGKUNGAN DI SMA NEGERI 5 BANJARMASIN
Authors: Adawiah Rabiatul 
Published: January 2021

Tujuan penelitian ini adalah untuk mengetahui implementasi program Adiwiyata di SMA Negeri 5 Banjarmasin dan mengetahui kepedulian siswa terhadap lingkungan. Penelitian ini menggunakan pendekatan kualitatif, dan data dikumpulkan melalui observasi dan wawancara. Analisis data dilakukan secara kualitatif. Hasil penelitian ini menunjukkan bahwa Implementasi program adiwiyata dalam membentuk sikap kepedulian siswa terhadap lingkungan dilakukan melalui kegiatan Jumat bersih yang dilaksanakan setiap bulan, mendirikan bank sampah, yang kegiatannya dikoordinir oleh salah satu guru dan beberapa siswa, dan menyediakan sarana dan prasarana penunjang kebersihan lingkungan sekolah. Kepedulian siswa terhadap lingkungan sekolah masih kurang. Rekomendasi dari Penelitian ini diantaranya, program Adiwiyata hendaknya dirancang dengan melibatkan berbagai unsur di luar sekolah seperti orang tua dan masyarakat, penanaman sikap peduli lingkungan hendaknya dilakukan secara kuntinu dan konsisten dan untuk memotivasi siswa peduli terhadap lingkungan, hendaknya secara periodik dilakukan lomba kebersihan antar kelas. Kata Kunci : Implementasi, Adiwiyata, Sikap, Peduli Lingkungan.
PENGELOMPOKAN PERSENTASE BUTA HURUF UMUR 15-44 MENURUT PROVINSI MENGGUNAKAN ALGORITMA K-MEANS
Authors: Saifullah Saifullah , Hidayati Nani 
Published: January 2021

<p><em>Data Mining is a method that is often needed in large-scale data processing, so data mining has important access to the fields of life including industry, finance, weather, science and technology. In data mining techniques there are methods that can be used, namely classification, clustering, regression, variable selection, and market basket analysis. Illiteracy is one of the factors that hinder the quality of human resources. One of the basic things that must be fulfilled to improve the quality of human resources is the eradication of illiteracy among the community. The purpose of this study is to determine the clustering of illiterate communities based on provinces in Indonesia. The results of the study are illiterate data clustering according to the age proportion of 15-44 namely 1 high group node, low group has 27 nodes, and medium group 6 nodes. The results of this study become input for the government to determine illiteracy eradication policies in Indonesia based on provinces.</em></p><p><strong>Kata Kunci</strong>: <em>Illiterate</em><em>, Data mining, K-Means Clustering</em></p><p><em>Data Mining termasuk metode yang sering dibutuhkan dalam pengolahan data berskala besar, maka data mining mempunyai akses penting pada bidang kehidupan diantaranya yaitu bidang industri, bidang keuangan, cuaca, ilmu dan teknologi. Pada teknik data mining terdapat metode-metode yang dapat digunakan yaitu klasifikasi, clustering, regresi, seleksi variabel, dan market basket analisis. Buta huruf merupakan salah satu faktor yang menghambat kualitas sumber daya manusia. Salah satu hal mendasar yang harus dipenuhi untuk meningkatkan kualitas sumber daya manusia adalah pemberantasan buta huruf di kalangan masyarakat</em><em> </em><em>Adapun tujuan penelitian ini adalah menetukan clustering masyarakat buta huruf</em><em> berdasarkan propinsi di Indonesia</em><em>.</em><em> </em><em>Hasil dari penelitian adalah data clustering buta huruf menurut propisi umur 15-44 yaitu</em><em> 1 node</em><em> kelompok tinggi</em><em>, kelompok rendah memiliki 27 node</em><em>, dan kelompok sedang 6 node. Ha</em><em>sil penelitian ini menjadi bahan masukan kepada pemerintah untuk menentukan kebijakan</em><em> </em><em>pemberantasan buta huruf di Indonesia berdasarakn propinsi</em><em>.</em></p><p><strong>Kata Kunci</strong>: Buta Huruf, Data mining, <em>K-Means Clustering</em><em></em></p>
One year follow-up and mediation in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for adult depression
Authors: A-Tjak Jacqueline G.L. , Morina Nexhmedin , Topper Maurice , Emmelkamp Paul M.G. 
Published: January 2021

Abstract
Background Existing therapies for depression are effective, but many patients fail to recover or relapse. To improve care for patients, more research into the effectiveness and working mechanisms of treatments is needed. We examined the long-term efficacy of Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT) for Major Depressive Disorder (MDD), testing the hypothesis that CBT outperforms ACT and that both therapies work through their designated mechanisms of change.Methods We conducted a randomized controlled trial with 82 patients suffering from MDD. Data were collected before, during and after treatment, and at 12-month follow-up, assessing symptoms of depression, quality of life, dysfunctional attitudes, decentering , and experiential avoidance.Results Patients in both conditions reported significant and large reductions of depressive symptoms (d = -1.26 to -1.60) and improvement in quality of life (d = 0.91 to -1.28) 12 months following treatment. Our findings indicated no significant differences between the two interventions. Dysfunctional attitudes and decentering mediated treatment effects of depressive symptoms in both CBT and ACT, whereas experiential avoidance mediated treatment effects in ACT only. Conclusions Our results indicate that CBT is not more effective in treating depression than ACT. Both treatments seem to work through changes in dysfunctional attitudes and decentering, even though the treatments differ substantially. Change in experiential avoidance as an underlying mechanism seems to be an ACT-specific process. Further research is needed to investigate whether ACT and CBT may work differently for different groups of patients with depression.Trial registration clinicaltrials.gov; NCT01517503. Registered 25 January 2012 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT01517503?term=NCT01517503&rank=1
Rickettsia spp. in rodent-attached ticks in Estonia and first evidence of spotted fever group Rickettsia species Candidatus Rickettsia uralica in Europe.
Authors: Vikentjeva Maria , Geller Julia , Remm Jaanus , Golovljova Irina 
Published: January 2021

Abstract
BACKGROUND: Rickettsia spp. are human pathogens that cause a number of diseases and are transmitted by arthropods, such as ixodid ticks. Estonia is one of few regions where the distribution area of two medically important tick species, Ixodes persulcatus and I. ricinus, overlaps. The presence of the nidicolous rodent-associated I. trianguliceps has also recently been shown in Estonia. Although there is no data available in Estonia on human disease caused by tick-borne Rickettsia spp., the presence of three Rickettsia species in non-nidicolous ticks was also previously reported. The aim of this study was to detect, identify and partially characterize Rickettsia species in nidicolous and non-nidicolous ticks attached to rodents.RESULTS: Larvae and nymphs of I. ricinus (n = 1004), I. persulcatus (n = 75) and I. trianguliceps (n = 117) removed from rodents and shrews caught in different parts of Estonia were studied for the presence of Rickettsia spp. by nested PCR. Ticks were collected from 314 small animals of 5 species (Myodes glareolus (bank voles), Apodemus flavicollis (yellow necked mice), A. agrarius (striped field mice), Microtus subterranius (pine voles) and Sorex araneus (common shrews)). Rickettsial DNA was detected in 8.7% (103/1186) of the studied ticks. In addition to R. helvetica previously found in questing ticks, this study reports the first identification of the recently described I. trianguliceps-associated Candidatus R. uralica west of the Ural Mountains.
Constructing and purifying megabodies starting from individual nanobody sequences
Authors: Uchański Tomasz , Fischer Baptiste , Kalichuk Valentina , Wohlkönig Alexandre , Zögg Thomas , Pardon Els , Steyaert Jan 
Published: January 2021

Abstract
Megabodies are engineered nanobodies that help overcome two major obstacles that limit the resolution of single-particle cryo-EM reconstructions: particle size and preferential orientation at the water-air interfaces. Here we describe how nanobodies can be rigidly grafted onto selected protein scaffolds (HopQ or YgjK) to increase their molecular weight while retaining the full antigen binding specificity and affinity. We also describe the protocols to purify these chimeric molecules from the periplasm of E. coli.
Hyperthermia by Near Infrared Radiation Induced Immune Cells Activation and Infiltration in Breast Tumor
Authors: Zawawi Wan Fatin Amira Wan Mohd , Hibma Merilyn , Salim Maheza Irna , Jemon Khairunadwa 
Published: January 2021

Abstract
Breast cancer is the most common cancer that causes death in women. Conventional therapies, including surgery and chemotherapy, have different therapeutic effects and are commonly associated with risks and side effects. Near infrared radiation is a technique with few side effects that is used for local hyperthermia, typically as an adjuvant to other cancer therapies. The understanding of the use of near NIR as a monotherapy, and its effects on the anti-tumour immune response, is limited. In this study we investigate the effects of HT treatment using NIR on tumor regression and on the anti-tumor immune response in breast tumors. Results demonstrated that local HT by NIR at 43oC reduced tumor progression and prolonged the survival of tumor-bearing mice. Immunohistochemical analysis revealed a significant reduction in proliferation in treated tumor, which was accompanied by an abundance of heat shock protein 70 (Hsp70). Increased numbers of activated dendritic cells were observed in the draining lymph nodes of the mice, along with infiltration of T cells, NK cells and B cells into the tumor. In contrast, tumor-infiltrated regulatory T cells were largely diminished from the tumor. In addition, higher IFN-γ and lower IL-10 secretion was observed in blood of treated mice. Overall, this present study extends the understanding of using local HT by NIR to stimulate a favourable anti-tumor immune response against breast cancer.
Comparison of Microsatellite Instability Detection by Immunohistochemistry and Molecular Techniques in Colorectal and Endometrial Cancer
Authors: Dedeurwaerdere Franceska , Claes Kathleen , Dorpe Jo Van , Rottiers Isabelle , Meulen Joni Van der , Breyne Joke , Swaerts Koen , Martens Geert 
Published: January 2021

Abstract
DNA mismatch repair deficiency (dMMR) testing is crucial for diagnosing Lynch syndrome and detection of microsatellite unstable (MSI) tumors eligible for immunotherapy.In this study, we compared the diagnostic performance of three molecular MSI assays: polymerase chain reaction (PCR), MSI testing by Idylla TM and next-generation-sequencing (NGS) on 49 tumor samples (28 colorectal and 21 endometrial adenocarcinomas) versus immunohistochemistry (IHC). Discrepancies were investigated by MLH1 methylation analysis and integrated with germline results if available.Overall, the molecular assays achieved equivalent diagnostic performance for MSI detection with area under the ROC curves (AUC) of respectively 0.91 for Idylla TM and PCR, and 0.93 for NGS. In colorectal cancers with tumor cell percentage ≥ 30% all three molecular assays achieved 100% sensitivity and specificity (AUC = 1) versus IHC. Also, in endometrial cancers, all three molecular assays showed equivalent diagnostic performance, albeit at a clearly lower sensitivity ranging from 58% for IdyllaTM to 75% for NGS, corresponding to negative predictive values from 78% to 86%.PCR, IdyllaTM and NGS show similar diagnostic performance for dMMR detection in colorectal and endometrial cancers. Molecular MSI analysis has lower sensitivity for dMMR detection in endometrial cancer indicating that combined use of both IHC and molecular methods is recommended.Clinical Trial Number/IRB: B1172020000040, Ethical Committee, AZ Delta General Hospital
Molecule-based coherent light-spin interfaces for quantum information processing – optical spin state polarization in a binuclear Europium complex
Authors: Kumar Kuppusamy Senthil , Serrano Diana , Nonat Aline , Heinrich Benoît , Karmazin Lydia , Charbonnière Loïc , Goldner Philippe , Ruben Mario 
Published: January 2021

Abstract
The success of the emerging field of solid-state optical quantum information processing (QIP) critically depends on the access to resonant optical materials. Rare-earth ion (REI)- based molecular systems, whose quantum properties could be tuned taking advantage of molecular engineering strategies, are one of the systems actively pursued for the implementation of QIP schemes. Herein, we demonstrate the efficient polarization of 2 ground-state nuclear spins—a fundamental requirement for all-optical spin initialization and addressing—in a binuclear Eu(III) complex, featuring inhomogeneously broadened 5D0→7 F0 optical transition. At 1.4 K, long-lived spectral holes have been burnt in the transition: homogeneous linewidth (Γh) = 22 +/- 1 MHz, which translates as optical coherence lifetime (T2opt) = 14.5 +/- 0.7 ns, and ground-state spin population lifetime (T1spin) = 1.6 +/- 0.4 s have been obtained. The results presented in this study are a progressive step towards the realization of molecule-based coherent light-spin QIP interfaces.
Catalytic Wet Oxidating Fulvic Acid By Zero-Valent Copper Chitosan Activated Carbon Ball: Plackett-Buiman Design and Response Surface Modeling&nbsp;Optimization
Authors: Song Chaofei , Lv Yue , Qin Xia , Cui Jiaxin , Guo Chengrui , Steve-Harold Kaghembega 
Published: January 2021

Abstract
In this paper, the active component zero-valent copper (ZVC) supported by chitosan activated carbon ball (CTS-ACB) (i.e. ZVC/CTS-ACS catalyst) was successfully prepared. The characterization results showed obvious characteristics of activated carbon and zero-valent copper. The catalyst was used to degrade fulvic acid (FA) in catalytic wet oxidation(CWO) system. The two significant factors acidity and temperature were found with the statistical tool Plackett-Buimanhe(PB) in CWO for FA removal. Then the response surface methodology(RSM) model was used to optimize the experimental conditions in order to obtain the optimal FA removal rate. With the optimal experimental parameters, that is, a temperature of 94°C and an acidity of 3.8, the average maximum removal rate of FA was 93.02%, which was in agreement with the expected result of the model 93.86%, indicating that the model is well established. The comparison of catalytic performance showed that the addition of catalyst ZVC / CTS-ACS could increase the removal rate of FA, colour number(CN) and TOC by 93.6%, 83.5% and 81.9% respectively. The utilization of ZVC can greatly increase the mineralization rate of FA , which indicates the high catalytic activity and minerazation of the catalyst.
Preoperative Serum Lactate Dehydrogenase Level Predicts Progression and Prognosis in Patients with Glioma
Authors: Chen Xiao-Yong , Chen Jin-Yuan , Cai Lue-Ming , Chen Jia-Fang , Wu Zan-Yi , Dai Lin-Sun , Kang De-Zhi , Ding Chen-Yu 
Published: January 2021

Abstract
Background: To evaluate the value of serum Lactate Dehydrogenase (LDH) level in predicting recurrence and the overall survival (OS) of glioma patients.Methods: A total number of 216 patients with glioma in our institution were retrospectively recruited to analyze the relationship between preoperative serum LDH level and prognosis.Results: Overall, the average age of patients was 43.58±17.22 years old; 53.7% (116 of 216) of the enrolled patients were male. Multivariate analysis revealed that serum LDH level (odds ratio [OR]=0.97, 95% confidence interval [CI]=0.96-0.98, P<0.001) and World Health Organization (WHO) grade (grade II: OR=19.64, 95%CI=5.56-69.35, P<0.001; grade III: OR=19.50, 95%CI=7.08-53.73, P<0.001; grade IV: OR=15.23, 95%CI=4.94-46.97, P<0.001) were significant and independent of 1-year Progression-free survival (PFS) after adjusting for confounders. The predictive performance of serum LDH level was represented with area under curve (AUC) = 0.741, 95%CI=0.677-0.798. Multivariate Cox analysis revealed that LDH level (hazard ratio [HR]=2.56, 95%CI=1.59-4.15, P<0.001) and WHO grade (grade II: HR=4.58, 95%CI=0.56-37.23, P=0.155; grade III: HR=16.35, 95%CI=2.16-123.80, P=0.007; grade IV: HR=42.13, 95%CI=5.83-304.47, P<0.001) remained associated with survival at 2-year follow-up. At 3-year follow-up, lymphocyte count (HR=0.68, 95%CI=0.51-0.91, P=0.008), LDH level (HR=2.21, 95%CI=1.40-3.49, P=0.001), and WHO grade (grade II: HR=1.44, 95%CI=0.44-4.68, P=0.543; grade III: HR=4.99, 95%CI=1.68-14.87, P=0.004; grade IV: HR=16.96, 95%CI=6.13-46.93, P<0.001) remained associated with survival in multivariate Cox analysis.Conclusion: Our study demonstrated that preoperative serum LDH level could serve as a reliable indicator for predicting prognosis of glioma patients. Further multicenter studies are still required to verify our findings.
A High-content Screening Assay based on Automated Microscopy for Monitoring Antibiotic Susceptibility of Mycobacterium Tuberculosis Phenotypes
Authors: Kalsum Sadaf , Andersson Blanka , Das Jyotirmoy , Schön Thomas , Lerm Maria 
Published: January 2021

Abstract
Background Assays enabling efficient high throughput drug screening are necessary for the discovery of new anti-mycobacterial drugs. The purpose of our work was to develop and validate an assay based on live-cell imaging which can monitor growth of two distinct phenotypes of Mycobacterium tuberculosis and to test their susceptibility to commonly used TB drugs. Results Both planktonic and cording phenotypes were successfully monitored as fluorescent objects using the live-cell imaging system Incucyte S3, allowing collection of data describing distinct characteristics of aggregate size and growth. The quantification of changes in total area of aggregates was used to define IC50 and MIC values of selected TB drugs which revealed that the cording phenotype grew more rapidly and displayed a higher susceptibility to rifampicin. A checkerboard approach, testing pair-wise combinations of sub-inhibitory concentrations of drugs, revealed rifampicin, linezolid and pretomanid as superior in inhibiting growth of cording phenotype. Conclusion Our results emphasize the efficiency of using automated live-cell imaging and its potential in high-through put whole-cell screening to evaluate existing and search for novel antimycobacterial drugs.