bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring fingerpad deformation during active object manipulation
Authors: Delhaye Benoit P. , Schiltz Félicien , Barrea Allan , Thonnard Jean-Louis , Lefèvre Philippe 
Published: July 2021

AbstractDuring active object manipulation, the finger-object interactions give rise to complex fingertip skin deformations. These deformations are in turn encoded by the local tactile afferents and provide rich and behaviorally relevant information to the central nervous system. Most of the work studying the mechanical response of the finger to dynamic loading has been performed under a passive setup, thereby precisely controlling the kinematics or the dynamics of the loading. However, to identify aspects of the deformations that are relevant to online control during object manipulation, it is desirable to measure the skin response in an active setup. To that end, we developed a device that allows us to monitor finger forces, skin deformations, and kinematics during fine manipulation. We describe the device in detail and test it to precisely describe how the fingertip skin in contact with the object deforms during a simple vertical oscillation task. We show that the level of grip force directly influences the fingerpad skin strains and that the strain rates are substantial during active manipulation (norm up to 100%/s). The developed setup will enable us to causally relate sensory information, i.e. skin deformation, to online control, i.e. grip force adjustment, in future studies.
BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates
Authors: Fowler Philip W , Wright Carla , Spiers Helen , Zhu Tingting , Baeten Elisabeth ML , Hoosdally Sarah W , Cruz Ana Luíza Gibertoni , Roohi Aysha , Kouchaki Samaneh , Walker Timothy M , Peto Timothy EA , Miller Grant , Lintott Chris , Clifton David , Crook Derrick W , Walker A Sarah ,   The Zooniverse Volunteer Community,   The CRyPTIC Consortium
Published: July 2021

AbstractTuberculosis is a respiratory disease that is treatable with antibiotics. An increasing prevalence of resistance means that to ensure a good treatment outcome it is desirable to test the susceptibility of each infection to different antibiotics. Conventionally this is done by culturing a clinical sample and then exposing aliquots to a panel of antibiotics, thereby determining the minimum inhibitory concentration (MIC) of each drug. Using 96-well broth micro dilution plates with each well containing a lyophilised pre-determined amount of an antibiotic is a convenient and cost-effective way to measure the MICs of several drugs at once for a clinical sample. Although accurate, this is an expensive and slow process that requires highly-skilled and experienced laboratory scientists. Here we show that, through the BashTheBug project hosted on the Zooniverse citizen science platform, a crowd of volunteers can reproducibly and accurately determine the MICs for 13 drugs and that simply taking the median or mode of 11-17 independent classifications is sufficient. There is therefore a potential role for crowds to support (but not supplant) the role of experts in antibiotic susceptibility testing.
The efficacy of antimicrobial agents is decreased in a polymicrobial environment
Authors: O’Brien Thomas James , Figueroa Wendy , Welch Martin 
Published: July 2021

AbstractThe airways of people with cystic fibrosis (CF) often harbour diverse polymicrobial communities. These airway infections can be impossible to resolve though antibiotic intervention, even though isolates of the individual species present are susceptible to the treatment when tested in vitro. This suggests that susceptibility to antimicrobial agents may be altered in the presence of other microbial species. In this work, we investigate how polymicrobial cultures of key CF-associated species respond to challenge with species-specific antimicrobial agents; colistin (targets Pseudomonas aeruginosa), fusidic acid (targets Staphylococcus aureus) and fluconazole (targets Candida albicans). We found that, compared with growth in axenic cultures, the target organism was protected (sometimes by several orders of magnitude) from the effect(s) of the antimicrobial agent when grown in a polymicrobial culture. This decreased antimicrobial efficacy in polymicrobial cultures was found to have both phenotypic and inherited components. Whole genome sequencing of the colistin-resistant P. aeruginosa isolates revealed single nucleotide polymorphisms and indels in genes encoding lipopolysaccharide (LPS) biosynthesis or pilus biogenesis. Colistin resistance associated with loss-of-function mutations in the LPS biosynthetic gene, wzy, could be complemented by expression of the wild-type wzy gene in trans. Our findings indicate that the polymicrobial nature of the CF airways is likely to have a significant impact on the clinical response to antimicrobial therapy.
CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage
Authors: Conners Rebecca , McLaren Mathew , Łapińska Urszula , Sanders Kelly , Stone M. Rhia L. , Blaskovich Mark A. T. , Pagliara Stefano , Daum Bertram , Rakonjac Jasna , Gold Vicki A. M. 
Published: July 2021

AbstractThe Ff family of filamentous bacteriophages infect gram-negative bacteria, but do not cause lysis of their host cell. Instead, new virions are extruded via the phage-encoded pIV protein, which has homology with bacterial secretins. Here, we determine the structure of pIV from the f1 filamentous bacteriophage at 2.7 Å resolution by cryo-electron microscopy, the first near-atomic structure of a phage secretin. Fifteen f1 pIV subunits assemble to form a gated channel in the bacterial outer membrane, with associated soluble domains projecting into the periplasm. We model channel opening and propose a mechanism for phage egress. By single-cell microfluidics experiments, we demonstrate the potential for secretins such as pIV to be used as adjuvants to increase the uptake and efficacy of antibiotics in bacteria. Finally, we compare the f1 pIV structure to its homologues to reveal similarities and differences between phage and bacterial secretins.
Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus
Authors: Herb Brian R. , Glover Hannah J. , Bhaduri Aparna , Colantuoni Carlo , Bale Tracy L. , Siletti Kimberly , Linnarsson Sten , Hodge Rebecca , Lein Ed , Kriegstein Arnold R. , Doege Claudia A. , Ament Seth A. 
Published: July 2021

AbstractThe development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. We sequenced the transcriptomes of 40,927 cells from the prenatal human hypothalamus spanning from 6 to 25 gestational weeks and 25,424 mature neurons in regions of the adult human hypothalamus, revealing a temporal trajectory from proliferative stem cell populations to mature neurons and glia. Developing hypothalamic neurons followed branching trajectories leading to 170 transcriptionally distinct neuronal subtypes in ten hypothalamic nuclei in the adult. The uniqueness of hypothalamic neuronal lineages was examined developmentally by comparing excitatory lineages present in cortex and inhibitory lineages in ganglionic eminence from the same individuals, revealing both distinct and shared drivers of neuronal maturation across the human forebrain. Cross-species comparisons to the mouse hypothalamus identified human-specificPOMCpopulations expressing unique combinations of transcription factors and neuropeptides. These results provide the first comprehensive transcriptomic view of human hypothalamus development at cellular resolution.One-Sentence SummaryUsing single-cell genomics, we reconstructed the developmental lineages by which precursor populations give rise to 170 distinct neuronal subtypes in the human hypothalamus.
Emerald – a 16-rotor multicopter for stereo imaging
Authors: Zabunov Svetoslav , Mardirossian Garo , Strelnitski Katia 
Published: July 2021

Purpose
The current manuscript aims to propose a novel multirotor design.

Design/methodology/approach
This paper presents a novel 16-rotor multicopter design named Emerald. The novel design innovations and benefits are disclosed. Comparison to existing 16-rotor designs is carried out. Implementation areas where the novel idea shall yield benefit are discussed. A prototype of the presented design is described.

Findings
The herein proposed 16-rotor design has a number of benefits over existing 16-rotor multicopters. The paper elaborates on those advantages.

Research limitations/implications
The research was limited to prototype testing, as the presented design is a novel concept.

Practical implications
The motivation to research and develop this novel design is implementing the vehicle for stereoscopic photography and reconnaissance. The design is also applicable to carrying payloads while flying indoors.
Advanced debonding detection technique for aerospace composite structures
Authors: Sorrentino Assunta , Romano Fulvio , De Fenza Angelo 
Published: July 2021

Purpose
The purpose of this paper is to introduce a methodology aimed to detect debonding induced by low impacts energies in typical aeronautical structures. The methodology is based on high frequency sensors/actuators system simulation and the application of elliptical triangulation (ET) and probability ellipse (PE) methods as damage detector. Numerical and experimental results on small-scale stiffened panels made of carbon fiber-reinforced plastic material are discussed.

Design/methodology/approach
The damage detection methodology is based on high frequency sensors/actuators piezoceramics system enabling the ET and the PE methods. The approach is based on ultrasonic guided waves propagation measurement and simulation within the structure and perturbations induced by debonding or impact damage that affect the signal characteristics.

Findings
The work is focused on debonding detection via test and simulations and calculation of damage indexes (DIs). The ET and PE methodologies have demonstrated the link between the DIs and debonding enabling the identification of position and growth of the damage.

Originality/value
The debonding between two structural elements caused in manufacturing or in-service is very difficult to detect, especially when the components are in low accessibility areas. This criticality, together with the uncertainty of long-term adhesive performance and the inability to continuously assess the debonding condition, induces the aircrafts’ manufacturers to pursuit ultraconservative design approach, with in turn an increment in final weight of these parts. The aim of this research’s activity is to demonstrate the effectiveness of the proposed methodology and the robustness of the structural health monitoring system to detect debonding in a typical aeronautical structural joint.
Antecedents and consequences of fast-food restaurant customers' perception of price fairness
Authors: Singh Gurmeet , Slack Neale J. , Sharma Shavneet , Aiyub Asheefa Shaheen , Ferraris Alberto 
Published: July 2021

PurposeThis study examines the influence of service quality dimensions (food quality, physical environment quality and employee service quality) and brand image of fast-food restaurants on price fairness and its consequence on customer retention.Design/methodology/approachThis survey collected 331 responses using the public intercept method. Data analysis involved performing confirmatory factor analysis (CFA) on the measurement model, followed by structural equation modeling. Moderation analysis was performed using SPSS (model1 in process macro), while mediation was performed using model 4 in process macro.FindingsEmpirical results of this study revealed the positive effect of restaurant service quality dimensions on price fairness and price fairness on customer retention. It also revealed that brand image strengthened the restaurant service-quality/price fairness interrelationship, and that customer satisfaction partially mediated the price fairness/customer retention interrelationship.Research limitations/implicationsFindings of this study are useful to marketers and fast-food restaurateurs in establishing the right combination of service quality dimensions and brand image that increase perceptions of price fairness and increase customer satisfaction and retention.Originality/valueThis study contributes to advancing the theoretical foundations of customers' perceived price fairness and retention research, specifically in the understudied fast-food sector of emerging economies. It extends the application of the equity theory to expose the direct and indirect influences on customer perceived price fairness and customer retention. The findings provide a better understanding of price fairness perceptions.
Destination brand equity and tourist's revisit intention towards health tourism: an empirical study
Authors: Rahman Muhammad Sabbir , Bag Surajit , Hassan Hasliza , Hossain Md Afnan , Singh Rajesh Kumar 
Published: July 2021

PurposeThis paper aims to investigate the relationship between destination brand equity and tourist's revisit intention towards health tourism destinations. The study also examines the mediating effect of destination brand association between destination-based brand equity and travellers' revisit intention for health tourism destinations.Design/methodology/approachA survey instrument is used to examine the relationships in the proposed model using the co-variance-based structural equation modelling (SEM) technique. The collected primary data from two hundred forty-six respondents (n = 246) are analysed to test the relationship amongst exogenous, mediating, moderating and endogenous constructs articulated in the proposed structural model.FindingsEmpirical findings reveal that destination brand equity influences the revisit intention of a traveller for health tourism via destination brand association. The perceived trust, reliability and soft issues of a traveller moderate the relationship between destination brand equity and destination brand association. Enduring travel involvement also proves a significant moderation effect on the relationship between destination brand association and the revisit intention of a traveller for a health tourism destination.Practical implicationsThis paper is an initial attempt to develop and empirically examine a conceptual model of the intention of a traveller to revisit a health tourism destination in a dynamic process of information search using the data collected from current travellers after medical tourism-related trips. Results suggest that stakeholders must focus on hedonic and utilitarian factors of the destination that are recognised by travellers to encourage revisit for medical tourism.Originality/valueAlthough there have been numerous studies on health tourism. However, to the best of the authors' knowledge, this research is a pioneer in the healthcare tourism literature that links destination brand equity, brand association and revisit intention of a traveller for health tourism. These findings extend the knowledge of how healthcare tourism that is embedded with destination brand equity and destination brand association. The study findings potentially benefit the marketers for gaining competitive advantages through considering the experience of a traveller.
Assessing the impact of global financial crisis on the intermediation efficiency of Indian banks in the presence of non-performing loans
Authors: Goswami Anju 
Published: July 2021

PurposeBy incorporating the role of nonperforming loans (NPLs), the study aims to assess the impact of global financial crisis (GFC) on the intermediation efficiency of Indian banks for the period of 1998/99 to 2016/17.Design/methodology/approachTo obtain efficiency level of Indian banks, this study applied sequential data envelopment analysis (DEA) based directional distance function (DDF) approach, which performed simultaneous expansion of desirable output and reduction of undesirable output in the bank's loan production structure. Additionally, using fixed effect regression approach in the panel data framework, this study assesses both the phenomenon of σ- and unconditional β-efficiency convergence in public sector banks (PSBs), private banks (PBs), foreign banks (FBs) and overall scheduled commercial banks (SCBs) during the pre-crisis, crisis and post-crisis years in India.FindingsIrrespective of the bank's production model, the evidence suggests that the accounting NPLs as an undesirable output significantly deteriorating the intermediation technical efficiency levels of Indian banks, especially after the crisis years until the last year of the study period. This reflects that Indian banks failed more to achieve their financial intermediation objective in the post-crisis years as compared to the crisis and pre-crisis years. In-depth, statistical evidence of commercial bank ownership groups reveals that public sector banks exhibit a higher level of efficiency in pursuance of traditional loan-based activity followed by private and foreign banks. The study also found the existence of sigma convergence in technical efficiency levels of Indian banks and ownership groups as well.Originality/valueThis study is perhaps the first one, which present the robust evolution of Indian banks intermediation efficiency by taking into account both endogenous (i.e. NPLs as an undesirable output and equity as a quasi-fixed input in the bank production process) crisis and exogenous (i.e. global financial and economic stress) crises. Moreover, none of the existing studies have conducted sub-period wise analysis to show the apparent occurrence of both convergence properties in technical efficiency, adding novelty in the literature.
Board diversity and performance in a masculine, aged and glocal supply chain: new empirical evidence
Authors: Calabrese Giuseppe Giulio , Manello Alessandro 
Published: July 2021

Purpose
This study aims to contribute to the debate on the relationship between board diversity and performance, a hot topic for scholars and shareholders. A number of studies have found contrasting impacts of board diversity on firm performance and this paper adds new and original evidence in the context of the automotive supply chain focusing on gender, age and nationality diversity.

Design/methodology/approach
The authors propose a triple stage empirical analysis. First, the authors use linear models according to different performance indexes for investigating diversity (gender, age and nationality) within the board of directors and executives. Second, the authors investigate the issue of diversity in different contexts such as position in the supply chain, nationality of the owner and family/corporate ownership. Finally, the authors use non-linear models to find a better combination of diversity in terms of gender and nationality for retrieving some managerial implications.

Findings
First, the authors demonstrate a robust positive effect of women in board representation on firm performance in terms of profitability and firm risk. In the case of, age and nationality the results are more equivocal in particular for the former. Second, the authors depict board diversity in different contexts as follows: positioning in the supply chain, type and nationality of the final owner. Again, gender heterogeneity is more adequate in the complex firm as Tier 1 suppliers, corporate and foreign company.

Originality/value
The authors focused the analysis on a specific industry, shedding light on the main specificities linked to operating in certain phases of the supply chain, a substantial novelty in this field. The empirical evidence is based on a very large data set containing quantitative and qualitative information on a representative sample of 1,538 firms operating in the Italian automotive supply chain, one of the most relevant in Europe.
A new approach to bypass wire crossing problem in QCA nano technology
Authors: Majeed Ali , Alkaldy Esam 
Published: July 2021

Purpose
This study aims to replace current multi-layer and coplanar wire crossing methods in QCA technology to avoid fabrication difficulties caused by them.

Design/methodology/approach
Quantum-dot cellular automata (QCA) is one of the newly emerging nanoelectronics technology tools that is proposed as a good replacement for complementary metal oxide semiconductor (CMOS) technology. This technology has many challenges, among them being component interconnection and signal routing. This paper will propose a new wire crossing method to enhance layout use in a single layer. The presented method depends on the central cell clock phase to enable two signals to cross over without interference. QCADesigner software is used to simulate a full adder circuit designed with the proposed wire crossing method to be used as a benchmark for further analysis of the presented wire crossing approach. QCAPro software is used for power dissipation analysis of the proposed adder.

Findings
A new cost function is presented in this paper to draw attention to the fabrication difficulties of the technology when designing QCA circuits. This function is applied to the selected benchmark circuit, and the results show good performance of the proposed method compared to others. The improvement is around 59, 33 and 75% compared to the best reported multi-layer wire crossing, coplanar wire crossing and logical crossing, respectively. The power dissipation analysis shows that the proposed method does not cause any extra power consumption in the circuit.

Originality/value
In this paper, a new approach is developed to bypass the wire crossing problem in the QCA technique.
Investigating the acceptance of distance learning amongst Omani students: a case study from Oman
Authors: Mohamed Abdul Hakim Hassan Mustafa , Abdel Fattah Fadi Abdel Muniem , Bashir Mohamed Izzeldin AbdelRahman , Alhajri Maia , Khanan Akbar , Abbas Zaheer 
Published: July 2021

Purpose
In the COVID-19 pandemic, students were subjected to high pressure when they were forced to move to distance learning in a lockdown environment. Such a drastic move for communities living in groups with solid relationship ties comes at a price. This study aims to investigate the acceptance of distance learning amongst Omani higher education institutions (HEI) students during COVID-19 lockdown.

Design/methodology/approach
This is a quantitative research based on an online survey designed to study participants’ acceptance of distance learning during COVID-19 lockdown.

Findings
A sample of 757 Omani students was selected, of which 81.2% were female. About 60% of the students’ Age lies 15–20 years. The highest percentage (38.8%) of students belongs to the College of Arts and Humanities. A total of 80% of the students reported a moderate level of information technology skills, and also more than 80% of the students had never attended eLearning calls. Most of the students affirm the eLearning acceptance (students’ willingness to use eLearning tools for the tasks they are designed for), eLearning usefulness (using eLearning would enhance students’ performance), eLearning ease of use (the degree to which a student believes that using eLearning tools are free from effort), learning from home during COVID-19 and eLearning effectiveness (student’s satisfaction and the benefits student will gain from learning via online platforms). Multiple regression analysis confirms that more than 81% of the variation in the eLearning acceptance was explained by eLearning usefulness, eLearning ease of use, learning from home during COVID-19 and eLearning effectiveness independent variables. Moreover, these independent predictors have a positive association with eLearning acceptance.

Originality/value
This research intends to fill the gap in Omani HEI students’ acceptance of distance learning during the COVID-19 pandemic.