bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responses to balance challenges in persons with panic disorder: A pilot study of computerized static and dynamic balance measurements
Authors: Amiaz Revital , Kimel Naor Shani , Caspi Asaf , Czerniak Efrat , Noy Shlomo , Pelc Tatiana , Mintz Matti , Plotnik Meir 
Published: November 2021

IntroductionSeveral studies have shown an association between panic disorder (PD) and reduced balance abilities, mainly based on functional balance scales.This pilot study aims to demonstrate the feasibility of studying balance abilities of persons with PD (PwPD) using computerized static and, for the first time, dynamic balance measurements in order to characterize balance control strategies employed by PwPD.MethodsTwelve PwPD and 11 healthy controls were recruited. PD diagnosis was confirmed using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM‐IV), and the severity of symptoms was evaluated using the Hamilton Anxiety Scale (HAM‐A), PD Severity Scales (PDSS), and Panic and Agoraphobia Scale (PAS). Balance was clinically assessed using the Activities‐Specific Balance Confidence (ABC) scale and physically by the Mini‐Balance Evaluation Systems Test (Mini‐BESTest). Dizziness was evaluated using the Dizziness Handicap Inventory (DHI) scale. Postural control was evaluated statically by measuring body sway and dynamically by measuring body responses to rapid unexpected physical perturbations.ResultsPwPD had higher scores on the HAM‐A (17.6 ± 10.3 vs. 3.0 ± 2.9; p < .001), PDSS (11.3 ± 5.1 vs. 0; p < .001), and PAS (20.3 ± 8.7 vs. 0; p < .001) questionnaires and lower scores on the balance scales compared to the controls (ABC scale: 156.2 ± 5.9 vs. 160 ± 0.0, p = .016; Mini‐BESTest: 29.4 ± 2.1 vs. 31.4 ± 0.9, p = .014; DHI: 5.3 ± 4.4 vs. 0.09 ± 0.3, p < .001). In the static balance tests, PwPD showed a not‐significantly smaller ellipse area of center of pressure trajectory (p = .36) and higher body sway velocity (p = .46), whereas in the dynamic balance tests, PwPD had shorter recovery time from physical perturbations in comparison to controls (2.1 ± 1.2s vs. 1.6 ± 0.9 s, p = .018).ConclusionThe computerized balance tests results point to an adoption of a ‘‘postural rigidity’’ strategy by the PwPD, that is, reduced dynamic adaptations in the face of postural challenges. This may reflect a nonsecure compensatory behavior. Further research is needed to delineate this strategy.
The relationship between Instagram activity and female body concerns: The serial mediating role of appearance‐related comparisons and internalization of beauty norms
Authors: Piccoli Valentina , Carnaghi Andrea , Grassi Michele , Bianchi Mauro 
Published: November 2021

AbstractRecent research showed that body image concerns (i.e., drive for thinness and body dissatisfaction) may be associated with exposure to images on social networking sites. We analysed this relationship by taking into account the possible mediating role of both the appearance‐related comparisons (i.e., the comparison with others on a specific dimension) and the internalization of beauty standards (i.e., the acceptance of the predominant physical‐attractiveness societal standards) in the Italian context. In two studies, we showed that Instagram‐photo activity was positively associated with both drive for thinness and body dissatisfaction through the mediating role of appearance‐related comparisons on Instagram. We further showed that the association between Instagram‐photo activity and body image concerns was sequentially mediated by appearance‐related comparisons on Instagram and the internalization of beauty standards. Female participants who engaged in Instagram‐photo activity also expressed greater concerns about their bodies as they were highly likely to make more comparisons relative to the appearance dimension and show high levels of internalization of beauty standards. These findings are discussed within theoretical and applied implications in the social media domain. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Influence of Aib‐Containing Amphipathic Helical Chain Length in MAP(Aib)‐cRGD as Carrier for siRNA Delivery
Authors: Wada Shun‐ichi , Shibaike Akira , Hayashi Junsuke , Urata Hidehito 
Published: November 2021

AbstractMAP(Aib)‐cRGD, which is a conjugate of an α‐aminoisobutyric acid (Aib)‐containing amphipathic helical peptide [MAP(Aib)] with a αvβ3 integrin binding ligand, cRGD, at the C‐terminus of the helical peptide, has been developed for siRNA delivery into cells. In this work, we synthesized three peptides containing 19 (PI), 18 (PII), and 17 (PIII) amino acid residues in the helical peptide, which lack Aib, Leu‐Aib, and Lys‐Leu‐Aib residues present in the C‐terminus of the helical peptide of the parent MAP(Aib)‐cRGD, respectively. MAP(Aib)‐cRGD showed the siRNA delivery into cells and the RNAi effect both in the presence and in the absence of serum in reaction media. In contrast, PI delivered siRNA into cells, and this was followed by the RNAi effect in only serum‐free reaction media. On the other hand, siRNA delivery was abolished by the further reduction of the number of residues (PII and PIII) in the C‐terminus. Our data indicate that the Aib‐containing helical part requires 20 residues in the conjugation of the helical peptide with cRGD for the construction of carrier for siRNA delivery into cells.
Comparative differences of mitral valve‐in‐valve implantation: A new mitral bioprosthesis versus current mosaic and epic valves
Authors: Wang Dee Dee , O'Neill Brian P. , Caranasos Thomas G. , Chitwood W. Randolph , Stack Richard S. , O'Neill William W. 
Published: November 2021

AbstractObjectiveEvaluate transcatheter mitral valve replacement (TMVR) valve‐in‐valve (VIV) outcomes in three different mitral bioprostheses (of comparable measured internal diameters) under stable hemodynamic and surgical conditions by bench, echocardiographic, computerized tomography (CT), and autopsy comparisons pre‐ and post‐valve implantation in a porcine model under matched controlled conditions.BackgroundImpact of surgical bioprosthesis design on TMVR VIV procedures is unknown.MethodsFifteen similar‐sized Yorkshire pigs underwent pre‐procedural CT screening. Twelve had consistent anatomic features and underwent implantation of mitral bioprostheses. Four valves from each of three manufacturers were implanted in randomized fashion: 27‐mm Epic, 27‐mm Mosaic, and 25‐mm Mitris, followed by TMVR VIV with 26 Edwards Sapien3. Post‐VIV, suprasternal TEE studies were performed to assess hemodynamic function, followed by a gated contrast CT. After euthanasia, animals underwent necropsy for anatomic evaluation.ResultsAll 12 animals had successful VIV implantation with no study deaths. The post vivMitris (3.77 ± 0.36)/(2.2 ± 0.25 mmHg) had the lowest peak/mean trans‐mitral gradient and the vivEpic the highest (15.5 ± 2.55)/(7.09 ± 1.13 mmHg). All THVs (transcatheter heart valves) had greatest deformation within the center of the THV frame; with the smallest waist opening area in the vivEpic (329 ± 35.8 mm2) and greatest in the vivMitris (414 ± 33.12 mm2). Bioprosthetic frames without obvious radiopaque markers resulted in the most ventricular implantation of the THV's anteroseptal frame (Epic: −4.52 ± 0.76 mm), versus the most radiopaque bioprosthesis (Mitris: −1.18 ± 2.95 mm), and higher peak LVOT gradients (Epic: 4.82 ± 1.61 mmHg; Mitris: 2.91 ± 1.47 mmHg).ConclusionsThe current study demonstrates marked variations in hemodynamics, THV opening area, and anatomic dimensions among measured similarly sized mitral bioprostheses. These data suggest a critical need for understanding the potential impact of variations in bioprosthesis design on TMVR VIV clinical outcomes.
Ligand Enhanced Activity of In Situ Formed Nanoparticles for Photocatalytic Hydrogen Evolution
Authors: Simon Zoe C. , Lopato Eric M. , Bhat Maya , Moncure Paige J. , Bernhard Sarah M. , Kitchin John R. , Bernhard Stefan , Millstone Jill E. 
Published: November 2021

AbstractOne consistent challenge of both computational and empirical catalyst screening is ensuring that the variables chosen for the screen are driving the performance analyzed. Here, we compare photocatalytic hydrogen evolution from in situ formed Au and Au/Cu nanoparticles to nanoparticles of the same composition synthesized prior to being used as catalysts, as well as compare them to in situ formed Au and Au/Cu nanoparticles in the presence of exogeneous ligand. For all experiments, we observed that ligand‐terminated nanoparticles performed better than un‐stabilized in situ formed nanoparticles. We tested the generality of this result by studying Co, Ni, and Pd in the same system and also observed that the introduction of nanoparticle ligand leads to enhanced catalytic activity. Taken together, these results suggest 1) nanoparticle ligands can be beneficial, and even necessary, to produce catalysts with sustained activity 2) For computational prediction of these catalysts, factors relating to particle formation and stability need to be considered when both generating predictions as well as interpreting experimental results based on those predictions.
Rational Design of 1D Porous Carbon Microtubes Supporting Multi‐size Bi2O3 Nanoparticles for Ultra‐long Cycle Life Lithium‐Ion Battery Anodes
Authors: Xu Qianwen , Jiu Hongfang , Zhang Lixin , Song Wei , Gao Tiantian , Guo Fengbo , Li Xin , Wei Hao , Wang Congli , Liu Yujing , Wang Shirui 
Published: November 2021

AbstractMulti‐size Bi2O3 nanoparticles supported by 1‐dimensional (1D) porous carbon microtubes (ms‐Bi2O3/CMTs) were favorably constructed through surface‐ion release and in‐ situ oxidation strategy. The prominent 1D porous microtube materials with multi‐size nanoparticles structure can furnish more plentiful electrochemical active sites and shorten lithium storage paths for high‐speed redox reactions, which was conducive to ion transport kinetics. The CV tests with various scan rates verified lithium storage mechanism of ms‐Bi2O3/CMTs with diffusion/capacitance control coexistence. The complexes illustrated an ultra‐long cycle life and extraordinary reversible capacity: it still had a specific capacity of 392.6 mAh g−1 after 3000 cycles at 1 A g−1; and it manifested 546.3 mAh g−1 when it returned to 0.05 A g−1 and continued to 100 cycles after experiencing different current densities of 0.05–5 A g−1, which indicated that ms‐Bi2O3/CMTs is a prospective anode for lithium‐ion batteries (LIBs).
Photobase‐Driven Excited‐State Intramolecular Proton Transfer (ESIPT) in a Strapped π‐Electron System
Authors: Suzuki Naoya , Kubota Tomoya , Ando Naoki , Yamaguchi Shigehiro 
Published: November 2021

AbstractWe report a new design strategy for an excited‐state intramolecular proton transfer (ESIPT) fluorophore that can be used in acidic media. A photobasic pyridine‐centered donor‐acceptor‐donor‐type fluorophore is combined with a basic trialkylamine “strap”. In the presence of an acid, protonation occurs predominantly at the amine moiety in the ground state. A single‐crystal X‐ray diffraction analysis confirmed the formation of a pre‐organized intramolecular hydrogen‐bonded structure between the resulting ammonium moiety and the pyridine ring. Upon excitation, the intramolecular charge‐transfer transition increases the basicity of the pyridine moiety in the excited state, resulting in proton transfer from the amine to the pyridine moiety. Consequently, the fluorophore takes on a polymethine‐dye character in the ESIPT state, which gives rise to significantly red‐shifted emission with an increased fluorescence quantum yield.
Copper‐Catalyzed Direct Perfluoroalkylation of Heteroarenes
Authors: Baguia Hajar , Evano Gwilherm 
Published: November 2021

AbstractAn efficient and broadly applicable process is reported for the copper‐catalyzed direct perfluoroalkylation of C−H bonds in heteroarenes with commercially available perfluoroalkyl iodides. This reaction is based on a simple combination of copper(I) iodide and 1,10‐phenanthroline enabling the easy reduction of perfluoroalkyl iodides to the corresponding radical species that add to a wide range of heteroarenes including benzofurans, benzothiophenes, (aza)indoles, furans and pyrroles. High levels of regioselectivity were obtained in all cases and the efficiency and robustness of this process was highlighted by the direct perfluoroalkylation of furan‐containing peptides.
Synthetic Fuels from Biomass: Photocatalytic Hydrodecarboxylation of Octanoic Acid by Ni Nanoparticles Deposited on TiO2
Authors: Du Xiangze , Peng Yong , Albero Josep , Li Dan , Hu Changwei , García Hermenegildo 
Published: November 2021

AbstractDecarboxylation of low‐value fatty acids from biomass is a simple process to produce synthetic fuels suitable to be blended with gasoline or diesel. The present study reports the photocatalytic decarboxylation of octanoic acid in the presence of H2 by a series of modified TiO2 to form mixtures of n‐heptane and tetradecane as major products in variable proportions, depending on the photocatalyst and the reaction conditions. It was found that the photocatalytic activity increases upon an optimal reductive NaBH4 treatment, presumably by generation of surface oxygen vacancies and by the deposition of Ni nanoparticles in the appropriate loading. Under the optimized conditions, an almost complete octanoic acid conversion and a combined selectivity to n‐heptane and tetradecane over 80 % were reached at 10 h of UV/Vis light irradiation with a 300 W Xe lamp. No changes in the photocatalytic performance were observed for six consecutive runs. The present results illustrate the possibility that photocatalytic decarboxylation offers for the transformation of biomass into synthetic fuels under mild conditions.
Sustainable Route Toward N‐Boc Amines: AuCl3/CuI‐Catalyzed N‐tert‐butyloxycarbonylation of Amines at Room Temperature
Authors: Cao Yanwei , Huang Yang , He Lin 
Published: November 2021

AbstractN‐tert‐butoxycarbonyl (N‐Boc) amines are useful intermediates in synthetic/medicinal chemistry. Traditionally, they are prepared via an indirect phosgene route with poor atom economy. Herein, a step‐ and atom‐economic synthesis of N‐Boc amines from amines, t‐butanol, and CO was reported at room temperature. Notably, this N‐tert‐butyloxycarbonylation procedure utilized ready‐made substrates, commercially available AuCl3/CuI as catalysts, and O2 from air as the sole oxidant. This catalytic system provided unique selectivity for N‐Boc amines in good yields. More significantly, gram‐scale preparation of medicinally important N‐Boc amine intermediates was successfully implement, which demonstrated a potential application prospect in industrial syntheses. Furthermore, this approach also showed good compatibility with tertiary and other useful alcohols. Investigations of the mechanisms revealed that gold catalyzed the reaction and copper acted as electron transfer mediator in the catalytic cycle.
High‐voltage gain magnetically coupled half‐bridge Z‐source inverter
Authors: Aalami Mohammadamin , Babaei Ebrahim , Ghassem Zadeh Saeid 
Published: November 2021

AbstractIn this paper, a new impedance‐source inverter based on the half‐bridge configuration is presented. The proposed topology has two switches that make four working modes. These operational modes are analyzed in detail, leading to obtaining the proposed topology's boost‐factor. Besides, some equations are derived that are used to design passive elements such as capacitors and inductors. Besides, the voltage stresses on the switches and diodes are obtained. A comparative study from the boost‐factor point of view is depicted, which shows that the proposed topology brings a high boost‐factor at the output stage. By utilizing transformers, this topology gains a high boost‐factor which can be adjusted by changing transformers' windings' turn. In addition to this comparison, other detailed comparisons show that the proposed topology has a reduced number of components with reduced voltage stresses on the passive devices. Finally, to verify the proposed topology's valid performance, a prototype is designed, and its results are studied.
A DSP‐based implementation of fuzzy logic and predictive current control for a Sheppard–Taylor power factor correction converter
Authors: Bouafassa Amar , Fernández‐Ramírez Luis M. 
Published: November 2021

AbstractEnsuring a high electric power quality of power systems and electric machinery continues to be a major challenge for power engineers. The research on harmonic reduction and improvement of power factor in connection to alternating current (AC) networks has intensified. This paper focuses on the simulation and real‐time implementation of a single‐phase Sheppard–Taylor power factor correction (PFC) rectifier. Compared to conventional PFC rectifiers, this converter provides a better network current tracking and reduces voltage stresses. Furthermore, it proves an ability to control a detuning phenomenon from which most of the PFC circuits suffer. This yields a significant enhancement in the power quality (PQ). The proposed control scheme consists of two successive controllers: (1) a fuzzy logic controller (FLC) for the voltage loop, which ensures a good robustness to changes in parameters; and (2) a predictive current control (PCC), which allows to achieve a sinusoidal network current and improves the power factor. The proposed configuration is examined by simulation and implemented in real‐time using a dSPACE DS1104 controller board. The robustness of the proposed control is tested under different loading conditions and output voltage variations. The obtained results validate the superiority of the applied approach in terms of unity power factor (0.998), THD of the network current (3.7%, approximately), and fast dynamic response.
Comparison of electrostatic and mechanical cell sorting with limited starting material
Authors: Staunstrup Nicklas H. , Petersen Charlotte C. , Fuglsang Tina , Starnawska Anna , Chernomorchenko Ana , Qvist Per , Schack Vivien R. 
Published: November 2021

AbstractIsolation of multiple cell populations from limited starting material and with minimal influence on cell homeostasis and viability are common requirements in both basic and clinical research. Fluorescence‐activated cell sorting (FACS) is the most commonly applied sorting methodology with the majority of instruments being based on high pressure and electrostatic deflection. A more recent technology is based on a mechanical valve, operating at low pressure. In the present work we compared the two technologies by parallel sorting of small amounts of peripheral blood and umbilical cord blood on a BD FACSAria™ III and Miltenyi MACSQuant® Tyto® instrument. Concurrent manually performed magnetic‐based cell sorting served as reference. Sorting metrics, including purity and viability, were compared. Expression of the heat‐shock protein HSPA1A immediately post sorting and the proliferation potential of sorted T‐cells in vitro was assessed. In general, there was little to distinguish the two fluorescence‐activated technologies with regard to sorting metrics and HSPA1A expression. Variation, however, with respect to recovery and viability, was much smaller among Tyto sorted samples. The proliferation potential of Tyto‐sorted T‐cells was significantly higher compared to Aria‐sorted T‐cells, indicating that T‐cells of the Tyto instrument are less perturbed. In summary, cell types of blood origin including CD34+ cells could effectively be isolated from small input amounts with either fluorescence‐activated technology with little immediate effect on viability. The mechanical valve‐based sorting by the Tyto instrument; however, appeared to perturb the cells to a lesser extent as judged by their proliferation potential.
99mTechnetium‐pyrophosphate scintigraphy: a practical guide for early diagnosis of transthyretin amyloid cardiomyopathy
Authors: Tahara Nobuhiro , Lairez Olivier , Endo Jin , Okada Atsushi , Ueda Mitsuharu , Ishii Tomonori , Kitano Yoshinobu , Lee Hahn‐Ey , Russo Eleonora , Kubo Toru 
Published: November 2021

AbstractTransthyretin amyloid cardiomyopathy (ATTR‐CM) is caused by the cardiac deposition of insoluble amyloid fibrils formed by misfolded transthyretin proteins and is associated with various cardiac symptoms, such as progressive heart failure, conduction disturbance, and arrhythmia. The implementation of 99mtechnetium (99mTc)‐labelled bone radiotracer scintigraphy for diagnosing ATTR‐CM has enabled accurate diagnosis of the disease with high sensitivity and specificity and positioned this diagnostic modality as an integral part of disease diagnostic algorithms. In 2020, 99mTc‐pyrophosphate scintigraphy received exceptional approval for Japanese national health insurance reimbursement as a diagnostic method of ATTR‐CM. Nevertheless, the utility of 99mTc‐labelled bone radiotracer scintigraphy and the importance of an early diagnosis of suspected ATTR‐CM using this technique have yet to be internalized as common practice by general cardiologists, and guidance on daily clinical scenarios to consider this technique for a diagnosis of suspected ATTR‐CM is warranted. In this review, we discuss the utility of 99mTc‐labelled bone radiotracer scintigraphy for the early diagnosis of ATTR‐CM based on published literature and the outcomes of an advisory board meeting. This review also discusses clinical scenarios that could support early diagnosis of suspected ATTR‐CM as well as common pitfalls, correct implementation, and future perspectives of 99mTc‐labelled bone radiotracer scintigraphy in daily clinical practice. The clinical scenarios to consider 99mTc‐labelled bone radiotracer scintigraphy in daily practice may include, but are not limited to, patients with a family history of the hereditary type of disease; elderly patients (aged ≥60 years) with unexplained cardiac findings (e.g. cardiac hypertrophy associated with abnormalities on an electrocardiogram, heart failure with preserved ejection fraction associated with unexplained left ventricular hypertrophy, and heart failure with reduced ejection fraction associated with atrial fibrillation and left ventricular hypertrophy); and patients with cardiac hypertrophy associated with diastolic dysfunction, right ventricular/interatrial septum/valve thickness, left ventricular sparkling, or apical sparing. Cardiac hypertrophy and persistent elevation in cardiac troponin in elderly patients are also suggestive of ATTR‐CM. 99mTc‐labelled bone radiotracer scintigraphy is also recommended in patients with characteristic cardiac magnetic resonance findings (e.g. diffuse subendocardial late gadolinium enhancement patterns, native T1 increase, and increase in extracellular volume) or patients with cardiac hypertrophy and bilateral carpal tunnel syndrome.