bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secondary metabolites of downy birch buds (Betula pubescens Erch.)
Authors: Isidorov Valery A. , Nazaruk Jolanta , Stocki Marcin , Bakier Sławomir 
Published: October 2021

Abstract
The subject of this study is the composition of low-molecular-weight metabolites in downy birch (Betula pubescens) buds and their participation in protection from various kinds of stress. Using the GC-MS, 640 compounds were detected, of which 314 were identified in downy birch buds for the first time. The volatile components detected using the SPME technique mainly consisted (about 70% of the total ionic current of the chromatogram, TIC) of mixtures of sesquiterpenoids. The exudate covering the buds, along with sesquiterpenoids (approximately 60% of TIC), included flavonoids (25% of TIC). The main part of the material extracted by supercritical carbon dioxide from buds comprised sesquiterpenoids and triterpenoids (47 and 28% of TIC, respectively). Via column chromatography, 25 known compounds (mainly flavonoids and triterpenoids) were isolated, most of which were first discovered in the buds of downy birch. Many compounds of these classes have strong biological activity and probably either directly or indirectly perform a protective function in birch buds. An assumption is made about the biological role of a number of secondary metabolites (such as volatile isomeric megastigmatriens and triterpene seco-acids) as well as about these compounds’ possible means of biosynthesis, which were first discovered in the buds of downy birch.
The Hda1 histone deacetylase limits divergent non‐coding transcription and restricts transcription initiation frequency
Authors: Gowthaman Uthra , Ivanov Maxim , Schwarz Isabel , Patel Heta P , Müller Niels A , García‐Pichardo Desiré , Lenstra Tineke L , Marquardt Sebastian 
Published: October 2021

AbstractNucleosome‐depleted regions (NDRs) at gene promoters support initiation of RNA polymerase II transcription. Interestingly, transcription often initiates in both directions, resulting in an mRNA and a divergent non‐coding (DNC) transcript of unclear purpose. Here, we characterized the genetic architecture and molecular mechanism of DNC transcription in budding yeast. Using high‐throughput reverse genetic screens based on quantitative single‐cell fluorescence measurements, we identified the Hda1 histone deacetylase complex (Hda1C) as a repressor of DNC transcription. Nascent transcription profiling showed a genome‐wide role of Hda1C in repression of DNC transcription. Live‐cell imaging of transcription revealed that mutations in the Hda3 subunit increased the frequency of DNC transcription. Hda1C contributed to decreased acetylation of histone H3 in DNC transcription regions, supporting DNC transcription repression by histone deacetylation. Our data support the interpretation that DNC transcription results as a consequence of the NDR‐based architecture of eukaryotic promoters, but that it is governed by locus‐specific repression to maintain genome fidelity.
Employee Satisfaction and Job Performance in the Accommodation Sector: Basis for Human Resource Plans
Authors: Romasanta Arceli 
Published: October 2021

Purpose: It is impossible to meet the guest's needs when employees come and go, and it is costly to find new employees to recruit. The study aims to find ways of retaining employees while also investigating why they leave their jobs.
Design/Method/Approach: A descriptive-correlational method of research in a quantitative design was used to determine correlation between variables. The study was highly accepted in terms of a Cronbach α = .988 which indicates an excellent index of reliability. Survey questionnaires served as a tool to draw facts about employees’ satisfaction and employees’ level of job performance in the accommodation sector.
Findings: The study revealed the existing relationship between employee satisfaction and job performance in the accommodation sector. Based on the research findings, employee satisfaction is an important aspect that affects job performance and organizational success. Hence, the accommodation sector may leap at a chance of increasing employee satisfaction since it is the best predictor of job performance in the accommodation sector.
Theoretical Implications: This paper expanded the body of research on employee satisfaction in relation to Herzberg’s Theory: (1) hygiene factors such as work environment, wages and benefits, and job security if they are not present at work will lead to dissatisfaction; (2) motivator factors such as career and personal work will increase employee satisfaction; (3) employee satisfaction mediates relationship with job performance.
Originality/Value: This research can act efficiently through an enhanced human resource plan providing an optimal balance of human capital leading to increased productivity and retained quality employees.
Research Limitations/Future Research: This research opens avenues for future research on dynamic capabilities in the hotel sector.

Paper type: Theoretical
O cooperativismo e a função social constitucional da cooperação nas constituições da Itália e do Brasil
Authors: Joelma Candida 
Published: October 2021

O presente estudo tem por objetivo demonstrar os fundamentos da cooperação moderna, sempre presente nas relações humanas desde sua necessidade de sobrevivência. Tem-se que essa mesma cooperação configura-se como uma vivência existente no cerne do cooperativismo mundial, diretamente ligada à sua origem, à sua constituição como movimento social; contudo, mais ainda relacionada à sua durabilidade e à continuidade na importância econômica historicamente percebida. Ademais aliada a este ideia, apresentar-se-á a destaca importância dela nas Constituições italiana e brasileira, em especial incentivo ao cooperativismo nesses países. Desta forma, verifica-se que cooperar é trabalhar de forma sincronizada em busca do mesmo objetivo; sua prática, educa, desenvolvendo nas pessoas um senso participativo, humano e solidário. Nesse sentido, e buscando enfrentar os elementos de controle do problema e dos marcos teóricos bem como o conjunto de conceitos e relações explorados, o trabalho foi dividido em quatro itens desde a introdução, a primeira parte especificamente sobre a cooperação em si, a segunda sobre as elencadas Constituições e por fim, as considerações finais.
Application of artificial intelligence in the otoneurology diagnostic process – an overview
Authors: Krupa Anna , Sosna-Duranowska Magdalena , Borkowski Miłosz , Czajka Natalia , Skarżyński Piotr 
Published: October 2021

WstępNowoczesne technologie, tj. sztuczna inteligencja (AI), w niezwykłym tempie stają się elementem wspomagającym opiniowanie w zakresie diagnostyki dysfunkcji błędnika. Według naukowców sztuczna inteligencja szybko analizuje obszerne dane dzięki zastosowaniu algorytmów, a w rezultacie wyniki są szczegółowe i precyzyjne.Materiał i metodyW przeglądzie zawierają się wybrane publikacje z lat 2015–2021 dostępne w bazach: PubMed, Science Direct oraz Web of Science, dotyczące zastosowania uczenia maszynowego w diagnostyce częstych zaburzeń narządu przedsionkowego.WnioskiZ klinicznego punktu widzenia ze względu na liczne czynniki, które wpływają na odczucie zawrotów głowy i zaburzenia postawy, wprowadzenie sztucznej inteligencji do samodzielnej oceny funkcji narządu przedsionkowego nie jest jeszcze możliwe. W niniejszej pracy wskazuje się na potrzebę analizowania obiektywnych badań diagnostycznych zarówno przez uczenie maszynowe, jak i lekarza, co łącznie staje się istotnym elementem w pracy klinicznej.
The quality of life of families with a child with a central auditory processing disorder
Authors: Kobosko Joanna , Ganc Małgorzata , Skoczylas Anna , Jędrzejczak W. Wiktor , Skarżyński Henryk 
Published: October 2021

WstępW myśl podejścia skoncentrowanego na rodzinie (FCA) to rodzina odgrywa wiodącą rolę we wspieraniu dziecka z zaburzeniami słuchu w rozwoju, leczeniu i rehabilitacji. Jakość życia rodziny staje się zarówno celem interdyscyplinarnej diagnozy, jak i podejmowanych oddziaływań na jej rzecz. Jak dotąd nie ma badań nad jakością życia rodzin z dzieckiem z centralnymi zaburzeniami przetwarzania słuchowego (APD). W niniejszym badaniu postawiono pytanie o jakość życia rodzin z dzieckiem z APD, zwłaszcza w obszarze wsparcia specjalistycznego i wsparcia społecznego, oraz porównano jakość życia rodzin z dzieckiem z APD z jakością życia rodzin z dziećmi z różnymi niepełnosprawnościami.Materiał i metodyBadaniami objęto 38 rodzin z dziećmi z APD w wieku średnio 9,8 lat. Rodzice wypełnili kwestionariusz Family Quality of Life Survey-2006 (FQOLS-2006), który pozwala na ocenę jakości życia rodzin w 9 obszarach życia: Zdrowie rodziny, Sytuacja finansowa, Relacje rodzinne, Wsparcie innych osób, Wsparcie w ramach specjalistycznych usług, System wartości, Kariera zawodowa i przygotowanie do kariery, Czas wolny i rekreacja, Interakcje społeczne.WynikiOtrzymane wyniki wskazują na wyższą – na poziomie tendencji statystycznej – jakość życia ogółem rodzin z dzieckiem z APD w porównaniu do jakości życia rodzin z dziećmi z różnymi niepełnosprawnościami (oprócz głuchoty), lecz podobną do jakości życia rodzin z małymi dziećmi głuchymi. Badane rodziny z dzieckiem z APD najwyższą jakość życia przypisały obszarom: Relacje rodzinne, Zdrowie rodziny oraz Kariera zawodowa. Najniższe oceny jakości życia otrzymano w obszarach: Wsparcie w ramach specjalistycznych usług, Wparcie innych osób oraz Interakcje społeczne. Wśród usług specjalistycznych, z jakich korzystają rodziny z dzieckiem z APD, przeważa opieka medyczna świadczona przez lekarzy różnych specjalności (54%), w tym lekarzy psychiatrów (20%), na kolejnym miejscu plasują się: terapia logopedyczna (47%) oraz terapia psychologiczna wraz z poradnictwem psychologicznym i psychoterapią dla rodziców/rodzin (44%).WnioskiWyniki badania pozwalają na stwierdzenie, że dotychczasowe usługi specjalistyczne oferowane dzieciom z APD i ich rodzinom są niewystarczające względem istniejących potrzeb dzieci z APD oraz ich rodzin. Obszar ten z pewnością wymaga dalszych badań. FCA stwarza szansę na zmianę istniejącej sytuacji rodzin z dzieckiem z APD.
The application of 24-hour pharyngeal pH-monitoring in the diagnosis of patients with pharyngeal and laryngeal complaints
Authors: Włodarczyk Elżbieta , Skarżyński Henryk 
Published: October 2021

WstępRefluks krtaniowo-gardłowy (LPR) jest przewlekłym procesem chorobowym polegającym na wstecznym ruchu treści płynnej lub gazowej żołądka poprzez przełyk do gardła i krtani, co wywołuje ostre lub przewlekłe objawy zapalenia śluzówki krtani i gardła. W ostatnich latach coraz szerzej stosowana jest 24-godzinna pH-metria gardłowa, która umożliwia monitorowanie pozaprzełykowych manifestacji GERD.CelOcena częstości występowanie LPR u pacjentów zgłaszających się z powodu dolegliwości ze strony gardła i krtani, takich jak: ból, pieczenie, przewlekła lub nawracająca chrypka, z zastosowaniem 24-godzinnej pH-metrii gardłowej.Materiał i metodyBadaniem objęto 84 chorych (67 kobiet, 17 mężczyzn) w wieku 18–71 lat (średnia wieku – 48 lat) z dolegliwościami ze strony gardła i krtani. Pacjenci proszeni byli o wypełnienie kwestionariusza Skali Dolegliwości Refluksowych (RSI). Na podstawie obrazu krtani w badaniu wideolaryngostroboskopii wypełniono kwestionariusz Skali Patologii Refluksowej (RFS). U wszystkich pacjentów wykonano 24-godzinną pH-metrię gardłową. LPR rozpoznano na podstawie Ryan Score.WynikiU ponad połowy pacjentów (59,5%) rozpoznano LPR w pozycji pionowej (Ryan Score >9,41). Biorąc pod uwagę wyniki skali RSI, najczęściej zgłaszaną dolegliwością było chrząkanie, zaraz potem nadmierna ilość wydzieliny, chrypka oraz uczucie przeszkody w gardle. W obrazie krtani dominowały przede wszystkim takie objawy jak: rumień/przekrwienie szczególnie w okolicy chrząstek nalewkowych (ale również innych struktur krtani), przerost spoidła tylnego, obrzęk fałdów głosowych i obrzęk krtani.WnioskiW diagnostyce pacjentów zgłaszających się z powodu dolegliwości ze strony gardła i krtani należy brać pod uwagę występowanie refluksu krtaniowo-gardłowego, szczególnie jeżeli występuje korelacja pomiędzy zgłaszanymi dolegliwościami a obrazem endoskopowym krtani. W diagnostyce LPR użytecznym badaniem jest 24-godzinna pH-metria.
MARGENS V. 15, N. 24, JUN. 2021 - DOSSIÊ MARGENS, PODER E INSURGÊNCIAS NA AMÉRICA LATINA
Authors: SARMENTO-PANTOJA Augusto 
Published: October 2021

Abstract: When we take Latin America as a locus of reflection, in its multiplicity of cultures, cosmologies, ways of existing and resisting, it is inevitable to focus on the relationship between modernity, the State, violence, and racism, articulated with local forms of power in societies marked by experience colonizer and by what Achille Mbembe considers as fabulation processes, expressed by the fallacious invention of statements about the inhuman and savage inferiority of certain populations. The flow of historical processes of domination and oppression that still run through the open veins of Latin America, however, has never ceased to face insurgent collectivities that, in rural and urban contexts, (re)invent other identities and narratives, confronting mechanisms of subjugation and silencing, destabilizing state production in “non-law zones”, affirming subalternate identities and fighting for changes in power relations from the margins of the State, in the sense attributed by Veena Das and Deborah Poole. Thus, we seek, in this dossier, to bring together researchers who, from their empirical experiences or bibliographic discussions, reflect on: (1) the practices and discourses through which state agents and institutions update historical violence, producing zones of spatial and moral degradation by capturing, subjecting or even “recovering” bodies and existences; (two); the political claims against the violence engendered by neoliberal rationality, which undermines the human condition and the possibilities of building alliances and solidarities. In this sense, we also value the narratives about collective confrontations, past and contemporary, practiced by rural women and men (from forests, rivers, islands, quilombos, villages, and other territorialized spaces) against specific forms of local authorities and against the perverse logic of big capital over the earth and its human and non-human inhabitants. Thus, we seek to broaden the debates on the possibilities of reinscribing insurgent narratives that subvert the logic of oppression in scenarios that are always marked by violence, subjection, and silencing.Keywords: Insurgency. Resistance. Latin America. Violence.
Ekosistem Pesantren dalam Mewujudkan Manajemen Halal Supply Chain Menuju Madani Society 5.0
Authors: Suwanto Suwanto , Gunawan Indra 
Published: October 2021

Abstract
Halal supply chain management is certainly very strategic applied in the halal industry in the environment around the islamic boarding school towards madani society 5.0. This study aims to describe the principles of halal supply chain management in islamic boarding school; analyze the islamic boarding school ecosystem in realizing halal supply chain management, and explain the challenges of implementing the islamic boarding school based halal supply chain management towards madani society 5.0. This study uses a qualitative descriptive method using a hermeneutic content analysis model and the integration-interconnection approach in detail the islamic boarding school ecosystem in order to develop halal supply chain management. In general, the four principles of the halal supply chain, namely halal procurement, halal manufacturing, halal distribution, and halal logistics. The islamic boarding school ecosystem in implementing halal supply chain management certainly requires government support, transportation planning, information technology management, human resource management; collaborative relations, halal certification, and traceability of halal information.
Keywords: islamic boarding school, management, halal supply chain, and madani society 5.0.

Abstrak
Manajemen halal supply chain tentunya sangat strategis diterapkan pada industri halal di lingkungan sekitar pesantren menuju madani society 5.0. Penelitian ini bertujuan untuk menguraikan prinsip-prinsip manajemen halal supply chain pada pesantren; menganalisis ekosistem pesantren dalam mewujudkan manajemen halal supply chain; dan menjelaskan tantangan penerapan manajemen halal supply chain berbasis pesantren menuju madani society 5.0. Penelitian ini menggunakan metode deskriptif kualitatif dengan menggunakan model content analysis hermeneutik dan pendekatan integrasi-interkoneksi menganalisis secara rinci ekosistem pesantren dalam rangka mengembangkan manajemen halal supply chain. Secara umum empat prinsip halal supply chain, yaitu halal procurement (pengadaan), halal manufacturing (pengolahan), halal distribution (distribusi), dan halal logistic (rantai pasokan). Ekosistem pesantren dalam implementasi manajemen halal supply chain tentunya membutuhkan dukungan pemerintah, perencanaan transportasi, manajemen teknologi informasi, manajemen sumber daya manusia, hubungan kolaboratif, sertifikasi halal, dan ketelusuran informasi halal.
Kata kunci: pesantren, manajemen, halal suply chain, dan madani society 5.0.
Diálogo educativo con el paciente en la consulta de traumatología y ortopedia
Authors: Velázquez Tamez Laura Elizabeth 
Published: October 2021

Educational dialogue with patients in traumatology and orthopedics
Abstract
Introduction: This paper describes the educational dialogue with the patient and identifies teaching strategies and soft skills needed to make it happen. Method: first-order sampling with in depth interviews with specialists in traumatology and orthopedics with subsequent instrumental case analysis in second order sampling. Results: A four-step model is proposed to develop the educational dialogue with the patient. Teaching strategies and soft skills needed for doctors are identified to teach the patient to take care of their health. Conclusions: This model could guide the developing of this dialogue. Educational dialogue could reduce the conflicts in this medical specialty. It is suggested to deepen the teaching of these skills in medical training.
Organizaciones criminales en América Latina: una discusión conceptual y un marco comparativo para su reinterpretación | Criminal organizations in Latin America: a comparative conceptual framework for its reinterpretation
Authors: Alvarado Arturo 
Published: October 2021

El presente artículo analiza la evolución y los impactos de las organizaciones criminales armadas presentes en una proporción mayoritaria de las ciudades y países de América Latina, que ha erosionado la vida económica, social y la gobernanza democrática. El texto desarrolla un análisis de las organizaciones ilícitas, discute los alcances del concepto de Crimen Organizado (CO) y propone una categoría más incluyente de Organización Criminal (OC), para lograr una explicación más comprensiva que integra más agrupaciones, sus propósitos, sus relaciones sociales, políticas y entre ellas. Todas ejercen formas predatorias contra la población. Algunas son forjadoras de un nuevo orden coercitivo criminal.
The Fragility of Significance in the Hip Arthroscopy Literature
Authors: Parisien Robert L. , Trofa David P. , O’Connor Michaela , Knapp Brock , Curry Emily J. , Tornetta Paul , Lynch T. Sean , Li Xinning 
Published: October 2021

Background:
The purpose of the present study was to perform the first examination of the utility of p values and the degree of statistical fragility in the hip arthroscopy literature by applying both the Fragility Index (FI) and the Fragility Quotient (FQ) to dichotomous comparative trials. We hypothesized that dichotomous comparative trials evaluating categorical outcomes in the hip arthroscopy literature are statistically fragile.

Methods:
The PubMed and MEDLINE databases were queried from 2008-2018 for comparative studies evaluating dichotomous data in the hip arthroscopy literature. The present analysis included both randomized controlled trials (RCTs) and non-RCTs in which dichotomous data and associated p values were reported. Fragility analysis was performed with use of the Fisher exact test until an alteration of significance was determined.

Results:
Of the 5,836 studies screened, 4,156 met the search criteria, with 52 comparative studies included for analysis. One hundred and fifty total outcome events with 33 significant (p < 0.05) outcomes and 117 nonsignificant (p ≥ 0.05) outcomes were identified. The final FI incorporating all 150 outcome events from 52 comparative studies was only 3.5 (interquartile range, 2 to 6), with an associated FQ of 0.032 (interquartile range, 0.017 to 0.063). Twenty-two studies (42.3%) either failed to report loss to follow-up (LTF) data or reported LTF greater than the overall FI of 3.5.

Conclusions:
The peer-reviewed hip arthroscopy literature may not be as stable as previously thought, as the sole reliance on a threshold p value has proven misleading. We therefore recommend reporting of the FI and FQ, in conjunction with p values, to aid in the evaluation and interpretation of statistical robustness and quantitative significance in future comparative hip arthroscopy studies.
Fractures of the Base of the Fifth Metatarsal Bone
Authors: Bušková Kamila , Bartoníček Jan , Rammelt Stefan 
Published: October 2021

» Fractures of the proximal fifth metatarsal (PFMT) are one of the most common foot injuries, accounting for 61% to 78% of all foot fractures, but full consensus on their classification, diagnosis, and treatment has not yet been reached.» The most commonly accepted classification is that of Lawrence and Botte, who divided the location of PFMT fractures into 3 zones with respect to their healing potential.» Avulsion fractures of the tuberosity of the base (zone 1) generally heal well, and nonoperative treatment is commonly recommended.» Internal fixation may be considered for displaced fractures that extend into the fourth-fifth intermetatarsal joint (zone 2) as well as for nondisplaced fractures in athletes or high-demand patients, with the aims of reducing the healing time and expediting return to sport or work.» Stress fractures of the proximal diaphysis (zone 3) are preferably treated operatively, particularly in the presence of signs of delayed union. With nonoperative treatment, supportive measures such as ultrasonography or external/extracorporeal shockwave therapy have been demonstrated to have limited potential for the enhancement of fracture-healing.