bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis
Authors: Kotronias Rafail A. , Bray Jonathan J.H. , Rajasundaram Skanda , Vincent Flavien , Delhaye Cedric , Scarsini Roberto , Marin Federico , Terentes-Printzios Dimitrios , Halcox Julian P.J. , Mamas Mamas A. , Kharbanda Rajesh , Van Belle Eric , Banning Adrian P. 
Published: September 2021

Background:
Access site vascular and bleeding complications remain problematic for patients undergoing transcatheter aortic valve replacement (TAVR). Ultrasound-guided transfemoral access approach has been suggested as a technique to reduce access site complications, but there is wide variation in adoption in TAVR. We performed a systematic review and meta-analysis to compare access site vascular and bleeding complications according to the Valve Academic Research Consortium-2 classification following the use of either ultrasound- or conventional fluoroscopy-guided transfemoral TAVR access.

Methods:
Medline, Embase, Web of Science, and The Cochrane Library were searched to November 2020 for studies comparing ultrasound- and fluoroscopy-guided access for transfemoral TAVR. A priori defined primary outcomes were extracted: (1) major, (2) minor, and (3) major and minor (total) access site vascular complications and (4) life-threatening/major, (5) minor, and (6) life-threatening, major, and minor (total) access site bleeding complications.

Results:
Eight observational studies (n=3875) were included, with a mean participant age of 82.8 years, STS score 5.81, and peripheral vascular disease in 23.5%. An ultrasound-guided approach was significantly associated with a reduced risk of total (Mantel-Haenszel odds ratio [MH-OR], 0.50 [95% CI, 0.35–0.73]), major (MH-OR, 0.51 [95% CI, 0.35–0.74]), and minor (MH-OR, 0.59 [95% CI, 0.38–0.91]) access site vascular complications. Ultrasound guidance was also significantly associated with total access site bleeding complications (MH-OR, 0.59 [95% CI, 0.39–0.90]). The association remained significant in sensitivity analyses of maximally adjusted minor and total vascular access site complications (MH-OR, 0.51 [95% CI, 0.29–0.90]; MH-OR, 0.44 [95% CI, 0.20–0.99], respectively).

Conclusions:
In the absence of randomized studies, our data suggests a potential benefit for ultrasound guidance to obtain percutaneous femoral access in TAVR.

Registration:

URL:
https://www.crd.york.ac.uk/PROSPERO/
; Unique identifier: CRD42020218259.
Urban Struggles over Water Scarcity in Harare
Authors: Musemwa Muchaparara 
Published: September 2021

Abstract
This essay counters the growing tendency in current scholarship to attribute nearly all the enduring water scarcity problems to climate change. Focusing on Harare, Zimbabwe's capital city, this essay contends that recurrent water crises can only really be understood within the contentious, long, and complex history of water politics in the capital city from the colonial to the postcolonial period. Although the colonial and postcolonial states in Zimbabwe had very different ideological and racial policies, for various reasons, neither was willing nor able to provide adequate supplies of water to the urban poor even as water was abundant in the city's reservoirs. It posits that while the colonial government racialized access to water by restricting its use by urban Africans, the postcolonial government failed to change the colonial patterns of urban water distribution and did little to increase water supplies to keep pace with a swiftly growing urban population and a geographically expanding city.
Water Scarcity & Health in Urban Africa
Authors: Livingston Julie 
Published: September 2021

Abstract
Water is the cornerstone of public health. Yet many people living in Africa's cities face serious challenges obtaining an adequate supply of clean water. This situation, which poses significant public health concerns, promises only to grow in magnitude in the coming years as rapid urbanization and climate change meet head-on to further constrain urban water provision. This essay explores the relationship between water supply and health in urban Africa through the lens of water scarcity and health as political relationships as much as environmental or technical phenomena. By bringing infectious diseases like cholera and chronic ailments like kidney disease into the same frame of analysis, this essay also directs attention beyond the overwhelming public health focus on microbial contamination to emergent forms of water-related illness and injury that proceed unchecked.
Water Security in Africa in the Age of Global Climate Change
Authors: Isaacman Allen , Musemwa Muchaparara 
Published: September 2021

Abstract
This essay explores the multiple ways in which the nexuses between water scarcity and climate change are socially and historically grounded in ordinary people's lived experiences and are embedded in specific fields of power. Here we specifically delineate four critical dimensions in which the water crises confronting the African continent in an age of climate change are clearly expressed: the increasing scarcity, privatization, and commodification of water in urban centers; the impact of large dams on the countryside; the health consequences of water shortages and how they, in turn, affect other aspects of people's experiences, sociopolitical dynamics, and well-being, broadly conceived; and water governance and the politics of water at the local, national, and transnational levels. These overarching themes form the collective basis for the host of essays in this volume that provide rich accounts of conflicts and struggles over water use and how these tensions have been mitigated.
Clustering and Switching in Verbal Fluency Across Varying Degrees of Cognitive Control Demands: Evidence From Healthy Bilinguals and Bilingual Patients With Aphasia
Authors: Carpenter Erin , Peñaloza Claudia , Rao Leela , Kiran Swathi 
Published: September 2021

Abstract
Different linguistic contexts place varying amounts of cognitive control on lexical retrieval in bilingual speakers, an issue that is complicated in bilingual patients with aphasia (BPWA) due to subsequent language and cognitive deficits. Verbal fluency tasks may offer insight into the interaction between executive and language control in healthy bilinguals and BPWA, by examining conditions with varying cognitive control demands. The present study examined switching and clustering in verbal fluency tasks in BPWA and healthy bilinguals across single- and dual-language conditions. We also examined the influence of language processing and language proficiency on switching and clustering performance across the dual-language conditions. Thirty-five Spanish-English BPWA and twenty-two Spanish-English healthy bilinguals completed a language use questionnaire, tests of language processing, and two verbal fluency tasks. The semantic category generation task included four conditions: two single-language conditions (No-Switch L1 and No-Switch L2) that required word production in each language separately; one dual-language condition that allowed switching between languages as desired (Self-Switch); and one dual-language condition that required switching between languages after each response (Forced-Switch). The letter fluency task required word production in single-language contexts. Overall, healthy bilinguals outperformed BPWA across all measures. Results indicate that switching is more sensitive to increased control demands than clustering, with this effect being more pronounced in BPWA, underscoring the interaction between semantic executive processes and language control in this group. Additionally, for BPWA switching performance relies on a combination of language abilities and language experience metrics.
Pretraining the Noisy Channel Model for Task-Oriented Dialogue
Authors: Liu Qi , Yu Lei , Rimell Laura , Blunsom Phil 
Published: September 2021

AbstractDirect decoding for task-oriented dialogue is known to suffer from the explaining-away effect, manifested in models that prefer short and generic responses. Here we argue for the use of Bayes’ theorem to factorize the dialogue task into two models, the distribution of the context given the response, and the prior for the response itself. This approach, an instantiation of the noisy channel model, both mitigates the explaining-away effect and allows the principled incorporation of large pretrained models for the response prior. We present extensive experiments showing that a noisy channel model decodes better responses compared to direct decoding and that a two-stage pretraining strategy, employing both open-domain and task-oriented dialogue data, improves over randomly initialized models.
A Scoping Review of Data Sources for the Conduct of Policy-Relevant Substance Use Research
Authors: Geissler Kimberley H. , Evans Elizabeth A. , Johnson Julie K. , Whitehill Jennifer M. 
Published: September 2021

Objective Existing administrative and survey data are critical for understanding the effects of exigent policies on population health outcomes related to opioid, cannabis, and other substance use disorders (SUDs). The objective of this study was to determine the state of the data available for evaluating SUD-related health outcomes. Methods We performed a scoping review of national and state government data sources to measure and evaluate the effects of state policy changes on substance use and SUD-related health outcomes and health care use. We used Massachusetts as a case study for availability of relevant state-level data as well as national datasets with state-level indicators available to measure outcomes. We compared key features of each dataset to assess their usefulness for research and policy evaluation. We conducted our review during November 2018–March 2019, and we updated data availability as of March 2019 for all data sources. Results We identified 11 survey datasets, 12 national administrative datasets, and 10 state administrative datasets as being suitable for policy-relevant research and practice purposes. These datasets varied substantially in their usefulness for evaluation and research. Despite substantial data limitations, including prohibitive regulatory and monetary costs to obtain the data and limited availability, these data can be mined to examine a diversity of policy-relevant questions. Conclusions Findings provide a comprehensive resource for using survey and administrative data to evaluate the health effects of SUD-related policies and interventions. The construction of state-level public health data warehouses or record linkage projects connecting individual-level information in state data sources is valuable for analyzing the effects of policy changes. Understanding strengths and limitations of available data sources is important for ongoing research and evaluation.
The Diffusion and Circulation of Marxism in the Periphery: Mariátegui and Dependency Theory
Authors: Rubbo Deni Alfaro 
Published: September 2021

Examination of the diffusion of the work of José Carlos Mariátegui (1894–1930) among Brazilian social scientists exiled to Chile during the 1960s and 1970s shows that, despite their significant contact with it, there was no discussion of it in the main works of the dependency theorists, and therefore there is insufficient evidence to declare it a precursor of that theory. O exame da difusão da obra de José Carlos Mariátegui (1894–1930) entre os cientistas sociais brasileiros exilados no Chile durante as décadas de 1960 e 1970 mostra que, apesar de seu contato significativo com o país, não foi discutido nas principais obras da teóricos da dependência e, portanto, não há evidências suficientes para declará-lo um precursor dessa teoria.
COVID-19-related headache and sinonasal inflammation: A longitudinal study analysing the role of acute rhinosinusitis and ICHD-3 classification difficulties in SARS-CoV-2 infection
Authors: Straburzyński Marcin , Nowaczewska Magdalena , Budrewicz Sławomir , Waliszewska-Prosół Marta 
Published: September 2021

Background The genesis of headache in coronavirus disease 2019 (COVID-19) is currently unclear and the multitude of disease symptoms often further hinders locating the source of pain. Interestingly, many subjects with COVID-19 have symptoms of acute rhinosinusitis. The relation between nasal symptoms and headache in SARS-CoV-2 infection remains unknown. Methods This bi-center longitudinal study evaluated symptoms in consecutive COVID-19 patients in the participating practices. The first assessment was performed during the initial consultation after infection confirmation. That was followed up by a second consultation after a median 9 days. Results 130 patients were included in the study (80 women, 50 men; mean age 46.9 years). Headache was highly prevalent at the first visit (72%) and significantly associated with acute rhinosinusitis symptoms. The odds ratio for headache in subjects with rhinosinusitis was 3.5. Headache could be attributed to systemic viral infection in 96% and to acute rhinosinusitis in 51% of cases according to 3rd edition of the International Classification of Headache Disorders. Criterium C.3 (exacerbation of headache by pressure applied over paranasal sinuses) and C.4 (ipsilaterality of headache and sinusitis) had low sensitivity in headache attributed to acute rhinosinusitis. Conclusions Nasal inflammation is associated with headache in COVID-19, although the pain mechanism lies probably in a systemic reaction to the virus. 3rd edition of the International Classification of Headache Disorders criteria for headache attributed to acute rhinosinusitis need adjusting to the current understanding of acute sinonasal infection.
Targeting Young Viewers to Watch Traditional Television
Authors: Lum Elliot , Martinez Luisa , Soling Marcia 
Published: September 2021

Univision is a brand well-known to Hispanic viewers, but with fragmentation and so many choices within the media landscape, they had to break through the noise effectively. The challenge for Univision was to attract a younger demographic (18–34 year-olds) of loyal viewers to consume Spanish language programming by packaging the use of music and reggaeton in a new telenovela which would showcase premium content that appealed to audiences of all ages. They identified digital, social, radio, and out-of-home platforms consumed by these potential viewers to deliver content and awareness to bring the idea to life. The results exceeded all programming and sales estimates, grew the timeslot’s ratings, and brought in a younger audience than any 8 pm telenovela.
Neutrophil extracellular traps in feline cardiogenic arterial thrombi: a pilot study
Authors: Li Ronald HL , Nguyen Nghi , Stern Joshua A , Duler Laetitia M 
Published: September 2021

Objectives The aim of this study was to investigate the spatial distribution of neutrophil extracellular traps (NETs) in cardiogenic arterial thromboembolism (CATE). Specifically, we aimed to examine the related structural features of NETs in feline arterial thrombi in relation to their arterial locations. Methods Paraffin-embedded aortic bifurcations from nine cats with hypertrophic cardiomyopathy (four with CATE and five without) were deparaffinized, and NETs were identified by immunodetection based on colocalization of cell-free DNA, citrullinated histone H3 and neutrophil elastase. The distribution of NETs in thrombi within the aortic bifurcations and common iliac arteries (CIAs) was compared based on their proximity to the descending aorta (proximal, mid, distal). Ten random fields per section were captured at × 10 and × 20 magnification for each section of the clot and analyzed. Results The distributions of NETs in thrombi within the aortic bifurcation and CIAs were found to differ in relation to their assigned zones (proximal, mid, distal; P = 0.04); NETs were concentrated mostly in the proximal region in the aortic bifurcations (47.56%, interquartile range [IQR] 14.07–77.95) and CIAs (44.69%, IQR 24.65–85.28), compared with the distal regions (2.69%, IQR 0.10–50.04 [P = 0.027]; 7.08%, IQR 1.27–59.33 [P = 0.02]). Conclusions and relevance The variation in NET distribution within arterial thrombi may shed light on the pathogenesis of thrombus growth. This may be due to possible neutrophil entrapment or variations in shear stress.
‘The right man in the right place’ – the consequences of gender-coding of place and occupation in collaboration processes
Authors: Grip Lena , Jansson Ulrika 
Published: September 2021

Society needs to find new ways to utilise its resources in the best possible way in order to enable satisfactory services for its citizens in the long term. This is particularly important in sparsely populated areas, and in cities and municipalities with a declining population. This study contributes to this field by analysing a project for collaboration between the rescue service and the home-care service that has been introduced in a number of Swedish municipalities. The collaboration is intended to ensure welfare and safety for citizens, to guarantee a more efficient use of municipal resources, and to contribute to improved emergency management and civil protection. The rescue service and the home-care service are two clearly gender-coded occupations that also operate on gender-coded work places and places of work. An overarching aim has therefore been to study gendered obstacles and possibilities of the collaboration. In our analysis of the empirical data – interviews with persons involved in the collaboration – place emerged as an important aspect of the collaboration processes, and is therefore elaborated in this article to contribute with knowledge of how conceptions and gender-coding of places and occupations affect sustainable and well-functioning collaboration processes. The results show that collaboration processes between municipal services are complex and challenge ideals of the organisation, content and responsibility of work and who should perform certain work tasks. Notions of gender and gender differences are reproduced through the collaboration, which affect the efforts of municipalities to ensure welfare and safety for citizens.
The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging
Authors: Lauwers Eline , Belmans Dennis , Mignot Benjamin , Ides Kris , Van Hoorenbeeck Kim , Snoeckx Annemiek , Van Holsbeke Cedric , Nowé Vicky , Van Braeckel Eva , De Backer Wilfried , De Backer Jan , Verhulst Stijn 
Published: September 2021

Background: Lumacaftor/ivacaftor (LUM/IVA) has shown modest benefits in previous research, but the exact effects in the cystic fibrosis (CF) lung remain unclear. This study aims to offer novel information on the mode of action of the cystic fibrosis transmembrane conductance regulator (CFTR)-modulating drug by assessing lung structure and function using functional respiratory imaging (FRI). Methods: CF patients aged ⩾12 years homozygous for F508del were recruited in an open-label study. Before and after 12 weeks of treatment with LUM/IVA, FRI was used to visualize regional information, such as air trapping, lobar volume and airway wall volume. Secondary outcomes included the CF-CT scoring system, spirometry, the Cystic Fibrosis Questionnaire–Revised (CFQ-R) questionnaire, exercise tolerance and nutritional status. Results: Of the 12 patients enrolled in the study, 11 completed all study visits. Concerning the FRI parameters, hyperinflation of the lung decreased, indicated by a reduction in air trapping and lobar volume at expiration. Also, a decrease in airway wall volume and a redistribution of pulmonary blood volume were noted, which might be related to a decrease in mucus impaction. Airway resistance, airway volume, internal airflow distribution and aerosol deposition pattern did not show significant changes. No significant improvements were found in any of the CF-CT scores or in the spirometric parameters. Other secondary outcomes showed similar results compared with previous research. Correlations at baseline were found between FRI and conventional outcomes, including physical functioning, spirometry and CF-CT scores. Conclusions: LUM/IVA decreased lung hyperinflation in combination with a potential decrease in mucus impaction, which can be related to an improved mucociliary transport. These results indicate that several FRI parameters, reflecting regional and distal lung structures, are more sensitive to changes caused by LUM/IVA than conventional respiratory outcomes.
Kruppel-like factor 4 upregulates the resistance to apoptosis induced by tumor necrosis factor α in synovial fibroblasts with rheumatoid arthritis
Authors: Ni Chenghong , Zeng Shiyi , Zhang Chen , Lao Kehan , Wang Jifeng , Wang Weiwei , Mo Xuanrong , Luo Xinjing 
Published: September 2021

Objective The objective is to examine the effect of tumor necrosis factor α (TNFα) on apoptosis and proliferation of rheumatoid arthritis synovial fibroblasts (RASFs) and to elucidate the regulatory roles of Kruppel-like factor 4 (KLF4) in TNFα-induced RASF apoptosis. Methods Changes in cell proliferation were measured using an 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT) assay, and changes in cell apoptosis were detected by flow cytometry and Hoechst 33258 staining. Changes in the apoptosis-related protein caspase-3 and the apoptosis-related genes bcl-2/bax were measured by western blot and real-time PCR, respectively Results TNFα stimulation increased cell proliferation ( p < 0.05), decreased cell apoptosis ( p < 0.05), declined caspase-3 expression ( p < 0.05), and upregulated bcl-2/bax level ( p < 0.05) in RASFs. KLF4 gene silencing decreased cell proliferation ( p < 0.05), increased cell apoptosis ( p < 0.05), upregulated caspase-3 expression ( p < 0.05), and downregulated bcl-2/bax level ( p < 0.05) induced by TNFα in RASFs. Conclusions TNFα caused a decrease in RASF apoptosis, and KLF4 promoted resistance to TNFα-induced apoptosis and cell proliferation.
Interrater Reliability of the Prone Apprehension Relocation Test
Authors: Watchmaker Lauren E. , Hetzel Scott J. , Sink Ernest L. , Spiker Andrea M. 
Published: September 2021

Background: The Prone Apprehension Relocation Test (PART) augments existing radiographic measures and clinical provocative maneuvers in diagnosing hip instability. One measure of the potential clinical utility of the PART depends on the reproducibility of test results by evaluating providers including physicians, licensed athletic trainers, and physical therapists. Purpose: To determine the interrater reliability of the PART among health care providers. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: We retrospectively identified patients in our institution’s hip preservation registry who presented between September 2017 and June 2019 for evaluation of hip pain. Patients included in the study had the PART performed by a single physician as well as 1 of 12 physician extenders (a licensed athletic trainer or a physical therapist). The providers were blinded to the findings of the other examining professional. Interrater reliability was assessed using the Cohen κ (≥0.75 was considered excellent; between 0.75 and 0.40, moderate; and ≤0.40, poor). Results: A total of 96 patients (190 hips) were included in this study (61 women and 35 men, average age 32 ± 12.1 years). A total of 23 hips had a positive PART from both examiners. Interrater reliability was excellent between health care professionals for the PART when evaluating the right hip (κ = 0.80), left hip (κ = 0.82), and when combining the results for left and right (κ = 0.81). A subanalysis of patients with a positive PART from both raters demonstrated that 19 of the 23 hips had a lateral center-edge angle >25°. Conclusion: Our study demonstrated excellent interrater reliability of the PART, supporting its use in the physical evaluation of painful hips.