bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engpassvermeidung in der Patientenversorgung
Authors: Spohn K , Hiller M , Hering R , Schröder S 
Published: December 2021

Zusammenfassung
Zielsetzung In deutschen Krankenhäusern binden schlecht abgestimmte Prozesse Ressourcen und münden in Versorgungsengpässen. Negative Auswirkungen dessen und Verbesserungsmöglichkeiten sollen aufgezeigt werden.
Methodik Deskriptive systematische Literaturanalyse (Jhg. 2003–2020) in den Datenbanken PubMed und EBSCOhost.
Ergebnisse Von 860 Publikationen wurden 54 eingeschlossen. Lean-Management, Normalization Theory und Model for Improvement wurden beschrieben. Bedeutung eines Multi-Stakeholder Ansatzes wurde ausgeführt.
Schlussfolgerung Holistische Prozessoptimierungen können zunehmende Versorgungsengpässe abmildern. Früh sollten strategische in operative Ziele übersetzt und messbar gemacht werden. Innerklinische Projektbüros sollten Prozessimplementierungen begleiten und die Ausrichtung an Patientenversorgungs- und ökonomischen Aspekten im interdisziplinären Kontext steuern.
AGO-Algorithmen zur Behandlung von Brustkrebs: Update 2021
Authors: Schneeweiss Andreas , Fasching Peter A. , Fehm Tanja , Gerber Bernd , Jackisch Christian , Loibl Sibylle , Schmidt Marcus , Stickeler Elmar , Wöckel Achim , Janni Wolfgang , Müller Volkmar ,   on behalf of the AGO Kommission Mamma
Published: December 2021

ZusammenfassungDie in den Algorithmen aufgezeigten Behandlungsoptionen basieren zwar auf den aktuellen AGO-Empfehlungen, können aber nicht alle evidenzbasierten Behandlungsoptionen darstellen, da frühere Therapien, der Patientinnenstatus, Begleiterkrankungen, Patientinnenpräferenzen usw. bei der tatsächlichen Therapiewahl mitberücksichtigt werden müssen. Andere evidenzbasierte Behandlungsoptionen können in Einzelfällen auch angemessen und gerechtfertigt sein. Ungeachtet ihres Zulassungsstatus werden nur die Medikamente in den Algorithmen aufgenommen, die zum Zeitpunkt des letzten Algorithmus-Updates in Deutschland zugelassen waren. Die Aktualisierung der AGO-Behandlungsalgorithmen für die Therapie von frühen und metastasierten Brustkrebserkrankungen von 2021 wird hier vorgestellt. Diese Aktualisierung soll strukturierte Behandlungsentscheidungen durch die Darlegung reproduzierbarer, evidenzbasierter Therapiepfade verstärken und kann für eine breit angelegte Behandlungslandschaft nützlich sein.
The Story of the Fibrin(ogen) αC-Domains: Evolution of Our View on Their Structure and Interactions
Authors: Medved Leonid , Weisel John W. 
Published: December 2021

AbstractAlthough much has been established concerning the overall structure and function of fibrinogen, much less has been known about its two αC regions, each consisting of an αC-connector and an αC-domain, but new information has been accumulating. This review summarizes the state of our current knowledge of the structure and interactions of fibrinogen's αC regions. A series of studies with isolated αC regions and their fragments demonstrated that the αC-domain forms compact ordered structures consisting of N- and C-terminal subdomains including β sheets and suggested that the αC-connector has a poly(L-proline) type II structure. Functionally, the αC-domains interact intramolecularly with each other and with the central region of the molecule, first demonstrated by electron microscopy and then quantified by optical trap force spectroscopy. Upon conversion of fibrinogen into fibrin, the αC-domains switch from intra- to intermolecular interactions to form ordered αC polymers. The formation of αC polymers occurs mainly through the homophilic interaction between the N-terminal subdomains; interaction between the C-terminal subdomains and the αC-connectors also contributes to this process. Considerable evidence supports the idea that the αC-regions accelerate fibrin polymerization and affect the final structure of fibrin clots. The interactions between αC-regions are important for the mechanical properties of clots, increasing their stiffness and extensibility. Conversion of fibrinogen into fibrin results in exposure of multiple binding sites in its αC regions, providing interaction of fibrin with different proteins and cell types during hemostasis and wound healing. This heretofore mysterious part of the fibrinogen molecule is finally giving up its secrets.
Type and Intensity as Key Variable of Exercise in Metainflammation
Diseases: A Review
Authors: Figueiredo Caique , Padilha Camila S. , Dorneles Gilson P. , Peres Alessandra , Krüger Karsten , Rosa-Neto José Cesar , Lira Fabio S. 
Published: December 2021

AbstractMonocyte and lymphocyte subpopulations exhibit functions that vary between the
anti- and pro-inflammatory spectrum, such as classic CD16- and non-classical
CD16+monocytes, as well as T helper 2 lymphocytes (Th2), the
Th1/Th17 lymphocytes ratio, and T regulatory lymphocytes (Treg).
Metabolic disease-associated inflammation is accompanied by an imbalance in
monocyte and lymphocyte phenotypes and functionality, as well as a stronger
proportion of inflammatory subpopulations. These changes appear to be important
for the development and progression of diseases like diabetes and cardiovascular
disease. On the other hand, the regular practice of physical exercise is an
important tool to restore the functionality of monocytes and lymphocytes, and to
balance the subtypes ratio. However, key variables regarding exercise
prescription, such as the type of exercise, intensity, and volume differentially
impact on the acute and chronic immune response in individuals diagnosed with
meta-inflammation diseases. Here, we discuss the impact of different physical
exercise protocols, acutely and chronically, on monocytes and lymphocytes of
individuals with metabolic disease-associated inflammation. In this review, we
focus on the best effects of different exercise protocols to dose the
“exercise pill” in different inflammatory status.
Análise da deformação na prótese femoral não cimentada do quadril pelo método de elementos finitos – Influência da variabilidade do posicionamento angular do implante
Authors: Degasperi Felipe Alberto , Scatigna Bruno Francesco , Falótico Guilherme Guadagnini , Romero Valéria , Basile Ricardo , Takata Edmilson Takehiro 
Published: December 2021

Resumo
Objetivo Avaliar a influência da variação do posicionamento da prótese femoral do quadril na tensão e na deformação produzidas neste implante.
Métodos Utilizou-se a análise de tensão e de deformação da prótese femoral (Taper, Víncula, Rio Claro, SP, Brasil) pelo método de elementos finitos (MEF) de acordo com a norma ISO 7206-6 Implants for surgery - Partial and total hip joint prostheses–Part 6: Endurance properties testing and performance requirements of neck region of stemmed femoral components. A análise propôs uma ramificação do ensaio físico, com variação da angulação de +/− 5° sobre a proposta normativa das variáveis α e β.
Resultados Ao comparar com a deformação controle, houve significância estatística com a angulação isolada de +/− 5° do ângulo α, bem como com a associação de +/− 5° nas angulações α e β (p = 0,027 e 0,021, respectivamente). Já com a variação apenas do ângulo β, não houve variação significativa na deformação da prótese (p = 0,128). A posição da haste com maior deformação no implante foi com α = 5° e β = 14° (p = 0,032).
Conclusão A variabilidade de posicionamento da haste femoral protética de +/− 5° no plano coronal e/ou a associação da angulação de +/− 5° nos planos coronal e sagital interferiu de forma significativa na deformação do implante.
Breast Implants on Computed Tomography—A Pictorial Review of Normal and Pathologic Findings
Authors: Gossner Johannes 
Published: December 2021

AbstractBreast augmentation with implants is frequently performed. Therefore breast implants can be seen quite frequently on computed tomography (CT) of the body. This offers the possibility to detect incidental pathology and help to improve patient outcome. Basic knowledge about imaging findings of breast implants on CT is therefore needed for radiologists reporting body CT. CT may also be used for further workup of breast implants if magnetic resonance imaging (MRI) is contraindicated or not available. The purpose of this pictorial review is to give a brief overview of normal and pathologic findings of breast implants on CT.
Pulmonary Embolization of Radiolucent Intravenous Cannula: Endovascular Retrieval
Authors: Giragani Suresh , Singh Manish Kumar , Gonuguntla Hari kishan , Muthyala Swathi , Alwala Surender 
Published: December 2021

AbstractFracture and embolization of peripheral intravenous cannula is very rare. Although endovascular retrieval is the standard of care for most of the embolized intravascular devices, endovascular management of embolized peripheral intravenous cannula is technically difficult due to its radiolucent nature and it is not described previously in the literature. We describe the clinical presentation, imaging findings, and endovascular management in a middle aged male who had fractured peripheral intravenous cannula which was embolized into the pulmonary artery branch. Technical nuances associated with retrieval of this radiolucent little plastic tube have been discussed.
Regenerative Medicine Treatments for Androgenetic Alopecia
Authors: Mysore Venkataram , Alexander Sajin , Nepal Suman , Venkataram Aniketh 
Published: December 2021

AbstractRegenerative medicine and the role of stem cells are being studied for applications in nearly every field of medicine. The pluripotent nature of stem cells underlies their vast potential for treatment of androgenic alopecia. Several advances in recent years have heightened interest in this field, chief among them are the evolution of simpler techniques to isolate regenerative elements and stems cells. These techniques are easy, outpatient procedures with immediate injection, often single session with harvest, and minimal manipulation (usually physical). This paper seeks to critically review the existing data and determine the current evidence and their role in practice.
Extrapulmonary Tuberculosis Mimics Diffuse Metastatic Disease: A Case Report
Authors: Engin Gulgun , Yirgin Kızıldag , Kandemir Hulya 
Published: December 2021

Abstract
Background Extrapulmonary tuberculosis (TB) is associated with major diagnostic difficulties as it has many atypical symptoms and its imaging findings are similar to those of many other diseases.
Case Report We present the case of a 50-year-old woman with a complex cystic mass in her pelvis and a 2-month history of pain. Thoracoabdominal computed tomography (CT) revealed the following: (1) multiple supraclavicular, axillary, mediastinal, and abdominal pathologic lymph nodes with central hypoattenuation; (2) sternal and dorsal vertebral bone destruction with a soft tissue mass; and (3) multiple hypoattenuating masses in the liver. 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) revealed pathologic uptake in the defined areas, which were similar to metastases. Chest X-ray was normal. Diffuse metastatic disease was suspected clinically, but careful analysis of the imaging findings and the final pathologic results revealed multisystemic extrapulmonary TB. Clinical and radiological recovery was significant after anti-TB treatment at the 6-month follow-up.
Conclusion Extrapulmonary TB without pulmonary involvement is associated with major diagnostic difficulties, especially with PET-CT. However, recognition and understanding of the CT or MR imaging spectrum can aid in the correct diagnosis and management of the disease.
Both Bone Forearm Fracture with Complex DRUJ Dislocation: What Are the Odds?
Authors: Dabas Vineet , Bhatia Nishant , Agrawal Gaurang 
Published: December 2021

Abstract
Background Distal radioulnar joint (DRUJ) dislocation can occur as an isolated injury or in association with fracture radius (Galeazzi fracture-dislocation), Essex–Lopresti lesion or, rarely, with fracture of both radius and ulna (termed “Galeazzi type fracture”). DRUJ dislocations can be simple or complex. While simple DRUJ dislocation can be reduced by closed methods once the associated fractures are fixed anatomically, complex dislocation does not reduce by closed means. A complex DRUJ dislocation occurring in a both bone forearm fracture is an extremely unusual pattern of injury.
Case Description We describe the clinical presentation, intraop findings, management, and follow-up of two such cases of both bone forearm fracture with complex DRUJ dislocation. In both the cases, the ulnar head was found to be buttonholed through extensor retinaculum between the extensor tendons. Open reduction had to be done via dorsal approach. Timely intervention allowed good results in both the patients.
Literature Review Several authors have reported simple DRUJ dislocations in both bone forearm fractures; however, we could come across only three cases of complex DRUJ dislocation in a both bone forearm fracture. A summary of various series and reports on these injuries is presented.
Case Relevance Through this case report, we want to highlight this unusual association and emphasize on sequence of fixation, so that this perilous injury pattern is not missed, and favorable outcomes could be obtained through appropriate and timely intervention.
COVID-19 Infection: Impact on Hair
Authors: Sattur Sandeep Suresh , Sattur Indu Sandeep 
Published: December 2021

AbstractWith a practice dedicated to hair restoration and hair loss management, the authors have seen a large number of patients presenting with increased hair fall in the last 18 months. Hair fall after a stressfull event such as infections with febrile episodes is known. However, the latent period between the infective episode and hair fall has been shorter after COVID-19 infection than before. This review attempts to look at various pathways responsible for hair fall and if this differs from the conventional hair fall seen after any infection. It also tries to understand if the infection with the SARS-CoV-2 virus has a direct impact on the hair follicle leading to hair fall.
A Novel Mutation Diagnosing in Allan–Herndon–Dudley's Syndrome
Authors: Ipek Rojan , Bozdogan Sevcan Tug , Kömür Mustafa , Okuyaz Cetin 
Published: December 2021

AbstractAllan–Herndon–Dudley's syndrome (AHDS) is a rare X-linked recessive disease that causes abnormal serum thyroid function tests, severe hypotonia, intellectual disability, and motor deficit due to a mutation in the monocarboxylate transporter 8, which is a thyroid hormone transporter. A 6-month-old male patient presented to our outpatient clinic with a serious hypotonia complaint. With a preliminary diagnosis of AHDS, a molecular genetic examination was performed. The molecular genetic analysis detected a new previously unidentified variant in the SLC16A2 gene. This case has been presented to report the AHDS, which is a rare cause of hypotonia in patients presenting/consulting with severe hypotonia, global developmental delay, and abnormal thyroid function test results. Besides, a novel pathogenic mutation in the SLC16A2 gene has been described in the present article.
Prevalence of Helicobacter pylori Infection among Anemic School-Age Children in Egypt: A Cross-Sectional Population-Based Study
Authors: Abdelaziz Tarek A. , Almalky Mohamed , Hanna Diana , Baz Eman Gamal 
Published: December 2021

AbstractAnemia and Helicobacter pylori infection in school-age children are important public health problems. The association between H. pylori infection and the development of anemia, especially iron deficiency anemia, has been previously studied and until now it is still a matter of argument. This study aimed to determine the prevalence of anemia and H. pylori infection among school-age children and to find the association between H. pylori infection and anemia in school-age children. We conducted this population-based cross-sectional study in six Egyptian primary schools over a 12-month-period, including 1,200 students from all grades who fulfilled the inclusion criteria. The study participants were subjected to the following: medical history, clinical examination, and laboratory investigations included complete blood count and H. pylori antigen in stool, and according to the level of hemoglobin (Hb), we divided the students into two groups; the anemic group with Hb level <11.5 g/dL and nonanemic group with Hb level ≥11.5 g/dL, and the serum ferritin levels were measured only for the anemic group as the best indicator for iron status. The overall prevalence of H. pylori infection was 25%. The overall prevalence of anemia was 13.25%, of which hypochromic microcytic anemia represented 87.4% of the anemic group, and the mean ferritin level in the anemic group was 18.56 ± 9.96 ng/mL. The prevalence of anemia among H. pylori-infected patients (62.3%) was significantly (p < 0.001) higher than in noninfected children (37.7%). In the anemic group, the mean ferritin level in H. pylori-infected children was significantly lower than the mean level in the noninfected children (p <0.001). Furthermore, the anemic group had a significantly higher incidence of H. pylori infection and a lower age (p <0.001) in comparison with the nonanemic group. The dominant type of anemia in H. pylori-infected children was the microcytic hypochromic anemia, with a significantly higher incidence in comparison to other types of anemia (p <0.001). The findings of this study demonstrate a significant association between H. pylori infection and anemia in school-aged children, especially iron deficiency anemia, as the incidence of H. pylori infection was greater in anemic children than in non-anemic children.
Social dimensions in island restoration: some case studies from Aotearoa – New Zealand
Authors: Saunders Alan , Towns David , Broome Keith , Horn Stephen , Neureuter Sue , Conomos Katina , Corson Peter , Galbraith Mel , Gilbert Judy , Ogden John , Waterhouse Kate 
Published: December 2021

Islands have been a focus for biodiversity conservation in Aotearoa – New Zealand for more than 50 years. Recognition of the impacts of invasive predators, the significant outcomes that can be anticipated following their removal, and growing capacity to eradicate suites of pests from larger islands have underpinned this progress. Increasingly, attention is being directed at treating larger inhabited islands as well as mainland restoration sites where people live nearby and where the social dimensions become increasingly important. The case studies presented here illustrate changes to better acknowledge, consult and collaborate with tangata whenua (local Indigenous people). A focus on forging and maintaining relationships with other local stakeholders such as landowners and community groups is also illustrated. Other social dimensions such as political advocacy and securing institutional and financial support are also outlined in the case studies. We conclude that while much is being learned about opportunities to address social dimensions, those involved in promoting and implementing island restoration will need to remain flexible and apply locally nuanced approaches that reflect social as well as other circumstances at each site.
Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat
Authors: Chandran Vijayendran , Bermúdez Mei-Ling , Koka Mert , Chandran Brindha , Pawale Dhanashri , Vishnubhotla Ramana , Alankar Suresh , Maturi Raj , Subramaniam Balachundhar , Sadhasivam Senthilkumar 
Published: December 2021

SignificanceSeveral studies on the impact of yoga and meditation on mental and physical health have demonstrated beneficial effects. However, the potential molecular mechanisms and critical genes involved in this beneficial outcome have yet to be comprehensively elucidated. This study identified and characterized the transcriptional program associated with advanced meditation practice, and we bioinformatically integrated various networks to identify meditation-specific core network. This core network links several immune signaling pathways, and we showed that this core transcriptional profile is dysfunctional in multiple sclerosis and severe COVID-19 infection. Very importantly, we demonstrated that the meditative practice enhanced immune function without activating inflammatory signals. Together, these results make meditation an effective behavioral intervention for treating various conditions associated with a weakened immune system.
Ultrasound elasticity of diamond at gigapascal pressures
Authors: Hu Qingyang , Li Baosheng , Gao Xiang , Bi Yan , Su Lei , Mao Ho-kwang 
Published: December 2021

Significance
The exceptional hardness of diamond makes it an unmatched material for compressing and mechanical processing. For the same reason, compressing diamond and measuring its high-pressure, elastic properties turns out to be a very challenging task. Combining the ultrasonic interferometry and multianvil press, we extended the research forefront of diamond’s elasticity from kilobar to gigapascal pressures and showed that diamond becomes increasingly compressible, reaching agreement with theory. The results also point out the unique potential of diamond in providing an accurate, absolute pressure standard up to the terapascal region, which will be the basis cornerstone of the extensive, high-pressure sciences.
“These are not just slogans”
Authors: Kampf Zohar , Heimann Gadi , Aldar Lee 
Published: December 2021

Abstract
The goal of this study is to capture the meaning of interstate friendship from the perspective of international
actors and to underline the benefits of analyzing speech acts as a tool for revealing the relational scripts that guide interstate
relations. Analysis of the discourse surrounding 215 assertions of friendship made by statespersons in a variety of diplomatic
encounters and cultural contexts allows us to identify the factors that state actors articulate to develop friendly interstate
relations, the practices expected from a friendly state, and the goals attributed to practices of friendship. In the Conclusion we
discuss the differences between interpersonal and interstate friendships, and how the speech act of friendship plays a part in the
construction of interstate relations.
Method for time-of-flight estimation of low frequency acoustic signals in reverberant and noisy environment with sparse impulse response
Authors: Elfering Michael , Annas Sven , Jantzen Hans-Arno , Janoske Uwe 
Published: December 2021

Abstract
For acoustic procedures which rely on the speed of sound to derive process parameters, the determination of the acoustic time of flight (TOF) is essential. In this work, a method for the determination of the TOF is presented. It is intended for reverberant and noisy environments and can be applied in the gas holdup determination in bubbly liquids via acoustic transmission tomography for example. The method includes the selection and design of the transmitted signal to optimize the disambiguate of the autocorrelation, the narrowing of the time window based on the fractional Fourier transform to accelerate the TOF estimation. Furthermore, it includes the consideration of the system-induced signal distortion through prior quasi-anechoic measurements and the sparse reconstruction of the spatial impulse response for TOF estimation using non-negative sparse deconvolution algorithms. The method is tested analytically on numerically generated signals and various sparse deconvolution algorithms are investigated with respect to their applicability and limitations.