bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic and cumulative adverse life events in patients of premature ovarian insufficiency with unknown cause: an exploratory qualitative study
Authors: Sun Junyan , Fan Yihui , Guo Ying , Pan Huiying , Zhang Chen , Mao Guoping , Huang Yating , Li Boning , Gu Tingting , Wang Lulu , Zhang Qiuwan , Wang Qian , Zhou Qian , Li Bai , Lai Prof Dongmei 
Published: October 2021

Abstract
Background Premature ovarian insufficiency (POI) has serious physical and psychological consequences due to estrogen deprivation, leading to increased morbidity and mortality. However, the causes of most POI cases remain unknown (idiopathic POI). Environmental factors play an important role in the occurrence of complex diseases. To explore whether chronic and cumulative adverse life events occur in patients before POI diagnosis. Searching for the potential relative risk factors may find an intervention strategy to prevent POI in young women.Results Forty-three women (mean age=33·8 years) were recruited who were newly- diagnosed with idiopathic POI in a Chinese Ob/Gyn hospital to participate in semi-structured interviews through convenience sampling. The main questions covered by the topic guide were designed to explore adverse life events prior to POI diagnosis. Interviews were audio recorded, transcribed and analyzed thematically. Data were analyzed from June 2019 to August 2020. Among the POI patients, the mean age at diagnosis of POI was 33·8 years (range from 19 to 39 years), and the average time between the onset of irregular menstruation and POI diagnosis was 2.3 years. These patients had a relatively normal menstrual cycle before the diagnosis of POI. A number of stressful life events prior to POI diagnosis were discussed by them as important factors influencing their health and well-being. Four core themes emerged: 1) persistent exposure to workplace stress, 2) persistent exposure to family stress, 3) chronic sleep problem/disturbance existed in patients before POI diagnosis, and 4) participants' general cognition and concerns about POI. Conclusions Persistent exposures to adverse life events related to work stress, family stress and sleep disturbance exist in idiopathic POI patients. In addition, patients and their families generally have incorrect cognition of POI disease and its treatment. Future case-control studies should demonstrate whether chronic and cumulative adverse life events are risk factors of POI disease. Provision of tailored interventions (i.e. preventing or mitigating impact of adverse life events) aimed at high-risk populations is urgently needed to prevent new POI cases and promoting understanding of disease may improve health conditions of POI patients.
WITHDRAWN: MH370 Eastward Descent After the 6th Arc
Authors: Lyne Vincent 
Published: October 2021

Abstract
Past analyses of satellite and phone signals from missing Malaysian Airlines MH370 reconciled Burst Frequency Offset (BFO) errors up to the 6th of 7 arcs for a southerly track. After the 6th arc, the Satellite Data Unit (SDU) power-up or reboot resulted in settling errors. Investigators bounded these but needed to invoke a high-speed descent for nominal errors that remained from assuming the southerly track continued to the 7th arc. However, the implied violent-crash site was not found nor supported by damage found on debris, which instead suggested a glided landing. In our reanalysis, we relaxed the south track assumption and used the “Penang Longitude” (PL) theory that predicted a similar southerly track to the 6th arc, and that MH370 subsequently veered eastwards and descended. In essence, we simply replaced the Doppler Shift from vertical motions with horizontal veering of a high-speed aircraft. Our results suggests that veering predicted by the PL theory plus controlled descent plausibly accounts for nominal 7th arc BFO discrepancies. Synergistic resolution of observation by this theory suggests that MH370 did not violently crash at the 7th arc. Instead MH370 headed east towards a glide landing, predicted by the PL theory to be where the longitude of Penang intersects the 33oS latitude at a deep hole. The main lesson to learn is that all plausible scenarios need to be considered for complex high-uncertainty problems.
Contributions of disordered eating behaviours and mindful eating to obesity among young female adults
Authors: Bagcilar Seliz , Gezer Ceren 
Published: October 2021

Abstract
Purpose

The aim of the current study was to investigate the relationship between disordered eating behaviours, level of mindful eating and obesity amongst young female adults.
Methods

Two hundred and twenty-seven female young adults aged 19-35 living in Famagusta in North Cyprus participated in this current study. Mindful Eating Questionnaire (MEQ) and Eating Attitudes Test (EAT)-26 were used for data collecting through face-to-face interviews. Weight and body composition were obtained by body composition analyser and height were obtained by stadiometer. The measurements of neck circumference (NC), waist circumference (WC), hip circumference (HC) were measured by using a non-stretching tape according to standard techniques. Body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were calculated.
Results

The majority of participants (66.5%) had less than 20 points on the EAT-26. Overall, the participants with BMI below 18.5 kg/m2 had the highest MEQ scores, while the participants with BMI above 30.0 kg/m2 had the lowest MEQ scores (p < 0.05). Similarly, statistical significance was found between the MEQ scores of obese and normal weighted participants (p < 0.05). A significant negative correlation was found between MEQ scores and BMI, fat mass, WHR, WHtR, NC and WC (r=-0.216, p < 0.01; r=-0.234, p < 0.01; r=-172, p < 0.01 and r=-0.244, p < 0.01, r=-0.145, p < 0.05; r=-0.238, p < 0.05, respectively).
Conclusion

Our findings suggest that there is a negative relationship between the level of mindful eating and BMI. The evidence from this study also suggests a positive relationship between the risk of eating disorders and BMI.
Level of Evidence
Level V, cross-sectional descriptive study
Levetiracetam Alleviates Cognitive Decline in Alzheimer’s Disease Animal Model by Ameliorating the Dysfunction of the Neuronal Network
Authors: Zheng Xiang-yu , Lv Yu-Dan , Jin Feng-Yan , Zhang Hai-Chen , Wu Xiu-Juan , Zhu Jie , Ruan Yang 
Published: October 2021

Abstract
Patients with Alzheimer’s disease (AD) have a significantly higher risk of seizures than other individuals in an age-matched population, suggesting a close association between epilepsy and AD. We aimed to examine the effects of levetiracetam (LEV)—a drug for treating seizures—on learning and memory and neuropathological features of AD. We bred APP23 mice with MAPT transgenic mice to generate APP23/MAPT mice. These were treated with different concentrations of LEV in the presence of kainic acid (KA) for 3 months. The results revealed that low, but not high concentrations of LEV alleviated the effects of KA on memory defects in APP23/MAPT mice. Mechanistic investigations showed that low concentrations of LEV decreased tau phosphorylation by reducing the activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3α/β, thus rescuing neurons from synaptic dystrophy and apoptosis. Low concentrations of LEV inhibited the effects of KA (i.e., inducing neuroinflammation and impairing the autophagy of amyloid β-peptide), thus improving cognitive decline. High concentrations of LEV decreased the production and deposition of Aβ by reducing the expression of β site APP cleavage enzyme 1 and presenilin 1. However, high concentrations of LEV also induced neuronal apoptosis, decreased movement abilities in mice, and did not improve cognitive decline in AD mice. Our results support the hypothesis that aberrant network activity contributes to the synaptic and cognitive deficits in APP23/MAPT mice. Low, but not high concentration of LEV may help ameliorate abnormalities in people who have or are at risk of AD.
Emergence of the first manic episode in recovered COVID-19 patients: A case series from Egypt
Authors: Elgohary Hayam M. , Sehlo Mohammad G. , Youssef Usama M. , Abdelghani Mohamed 
Published: October 2021

Abstract
Objective

In December 2019, the novel coronavirus (COVID-19) infection was first reported in Wuhan city, China, which had rapidly spread as a global pandemic. This infection was commonly presented by respiratory and /or gastrointestinal symptoms. However, it is still unclear whether COVID-19 infection could be associated with central nervous system (CNS) damage which would result in development of neuropsychiatric symptoms.
Method

A total of five cases of suddenly emerged manic episodes during the pandemic of COVID-19 were extensively described. We presented the symptoms and described the diagnosis, clinical course, and treatment of each case.
Results

All patients had positive findings of ribonucleic acid (RNA) tests for COVID-19 in specimens of their sputum. The patients later developed manic symptoms during and after the recovering period of their illness.
Conclusions

The case series of newly emerged manic symptoms associated with COVID-19 infection highlights the essential need for evaluation of mental health status and would contribute to our understanding of the potential risk of CNS affection by COVID-19 infection. The limited number of cases would limit the generalizability of association. Future research should investigate the behavioral changes accompanying and following COVID-19 infection.
Nonlinear Finite Element Analysis of Free and Forced Vibrations of Cellular Plates Having Triangularly Prismatic Metamaterial Cores: A Strain Gradient Plate Model Approach
Authors: Torabi jalal , Niiranen Jarkko 
Published: October 2021

Abstract
The main objective of this paper is to develop a theoretically and numerically reliable and efficient methodology based on combining a finite element method and a strain gradient shear deformation plate model accounting for the nonlinear free and forced vibrations of cellular plates having equitriangularly prismatic metamaterial cores. The proposed model based on the nonlinear finite element strain gradient elasticity is developed for the first time to provide a computationally efficient framework for the simulation of the underlying nonlinear dynamics of cellular plates with advanced microarchitectures. The corresponding governing equations follow Mindlin’s SG elasticity theory including the micro-inertia effect applied to the first-order shear deformation plate theory along with the nonlinear von Kármán kinematics. Standard and higher-order computational homogenization methods determine the classical and strain gradient material constants, respectively. A higher-order \({C}^{1}\)-continuous 6-node finite element is adopted for the discretization of the governing variational formulation with respect to the spatial domain, and an arc-length continuation technique along with time periodic discretization is implemented to solve the resulting nonlinear time-dependent problem. Through a set of comparative studies with 3D full-field models as references, the accuracy and efficacy of the proposed dimension reduction methodology are demonstrated for a diverse range of problem parameters for analyzing the large-amplitude dynamic structural response.
Study on the Effect of Size on InGaN Red Micro-LEDs
Authors: Horng Ray-Hua , Ye Chun-Xin , Chen Po-Wei , Iida Daisuke , Ohkawa Kazuhiro , Wu Yuh-Renn , Wuu Dong-Sing 
Published: October 2021

Abstract
In this research, five sizes (100⊆100, 75⊆75, 50⊆50, 25⊆25, 10⊆10 µm2) of InGaN red micro-light emitting diode (LED) dies are produced using laser-based direct writing and maskless technology. It is observed that with increasing injection current, the smaller the size of the micro-LED, the more obvious the blue shift of the emission wavelength. When the injection current is increased from 0.1 to 1 mA, the emission wavelength of the 10×10 µm2 micro-LED is shifted from 617.15 to 576.87 nm. The obvious blue shift is attributed to the stress release and high current density injection. Moreover, the output power density is very similar for smaller chip micro-LEDs at the same injection current density. This behavior is different from AlGaInP micro-LEDs. The sidewall defect is more easily repaired by passivation, which is similar to the behavior of blue micro-LEDs. The results indicate that the red InGaN epilayer structure provides an opportunity to realize the full color LEDs fabricated by GaN-based LEDs.
ASCoVPred: a machine learning-based platform for quantitative prediction of anti-SARS-CoV-2 activity and human cell toxicity of molecules
Authors: Sharma Arun , Chaturvedi Neeraj , Gupta Dinesh 
Published: October 2021

Abstract
There is an urgent need to accelerate the discovery of effective drugs for COVID-19. We have developed machine learning models for rapid discovery of molecules potentially inhibitory to SARS-CoV-2 and negligible or no human cell toxicity. The machine learning (ML) QSAR models were trained and optimized with features (descriptors and fingerprints) of the experimentally validated SARS-CoV-2 inhibitory compounds. Several molecular descriptors and fingerprints were calculated to select the decisive ones for the training and evaluation of thousands of ML models. The best-optimized models are deployed as ASCoVPred webserver and standalone software, that provides easy and free access to the models. The feature selection for selecting the best descriptors for ML models training helped identify a set of decisive descriptors and fingerprints that correlate positively or negatively with the anti-SARS-CoV-2 activity and toxicity of the compounds. Systematic prediction and optimization of compounds with the help of ASCoVPred can facilitate the discovery of novel anti-SARS-CoV-2 compounds. The ASCoVPred web server and standalone software are freely available at http://14.139.62.220/ascovpred/.
LA EDUCACIÓN PERSONALIZADA. ALGUNAS PRECISIONES EN TORNO AL CONCEPTO
Authors: Maris Vázquez Stella , Teresita Daura Florencia 
Published: October 2021

El término Educación Personalizada es frecuentemente utilizado para aludir a un proceso educativo centrado en el estudiante y en la promoción del desarrollo integral de sus potencialidades.
El concepto de persona se emplea - en el modelo de la Educación Personalizada, acuñado por García Hoz— en un sentido dinámico, que puede identificarse con el de personalidad. Para probar esta hipótesis se analizan ciertos textos claves del autor y de algunos de los continuadores de su propuesta, a la luz de principios antropológicos y metafísicos.
LIDERAZGO EFICAZ PARA LA MEJORA ESCOLAR. UN ESTUDIO DE CASO DEL PROGRAMA ESCUELAS DE CALIDAD EN EL CENTRO DE MÉXICO
Authors: Romo Martínez José Matías 
Published: October 2021

En México, la desigualdad en la oferta de oportunidades educativas aún es un gran reto. Entre las políticas y programas implementados destaca el Programa Escuelas de Calidad (PEC), que inició hace diez años como una propuesta de reforma institucional y cambios en la gestión educativa. Se realizó un estudio de caso con una escuela exitosa inscrita en este programa, la cual se sitúa en una localidad rural del estado de Aguascalientes, México. El acercamiento se realizó a través de observaciones y entrevistas, con un enfoque interpretativo.
Las evidencias muestran, en este caso, que el liderazgo del director ha sido un factor preponderante, tanto para el éxito de la escuela como para la aplicación del PEC; entre los principales logros que se mencionan están: un trabajo colaborativo de los docentes, mayor participación social, progreso en el logro educativo de los alumnos, y una mejora sustancial en la infraestructura. Este tipo de estudios es importante para dar cuenta del impacto de una política pública en una escuela concreta, que además se ubica en un contexto social y económico desfavorable, en la que pareciera que el esfuerzo y la dedicación de su director, impulsado por la propuesta del PEC, han sido la clave del éxito.
«DE MORALITATE EDUCACTIONE» ESTUDIO SOBRE LA MORALIDAD DE LA EDUCACIÓN CON EL MÉTODO DE TOMÁS DE AQUINO
Authors: Saúl Gavito Fabiola E. 
Published: October 2021

El presente estudio pretende explicar una operación esencial del hombre: el perfeccionamiento al que tiende por naturaleza, el cual debe ser guiado por un quehacer humano indispensable: la educación.
Para introducirnos al estudio de la educación, será necesario partir de la etimología de la palabra, pero ir más allá —trascendiéndola— para llegar a una definición que contemple todos sus elementos, tanto los señalados en la concepción clásica, como en la actualidad. El hilo teórico a seguir será la filosofía aristotélico-tomista, recogiendo los comentarios de algunos autores contemporáneos al Filósofo y al Aquinate, o bien, ideas que se deriven o concuerden con la doctrina realista. Todo ello mediante el méto
EVALUACIÓN DIDÁCTICA DE SOFTWARE EDUCATIVO
Authors: Galbán Lozano Sara Elvira , Ortega Barba Claudia Fabiola 
Published: October 2021

Al ser el campo educativo un ámbito del actuar humano, también se ha visto –y se ve– influenciado por los cambios radicales del mundo. Se le imponen, así, nuevos retos a los cuales responder: la educación a lo largo de toda la vida, la cooperación internacional, la educación multicultural, el manejo de nuevas tecnologías, la revisión constante de los planes y programas de estudio, la evaluación continua de los procesos educativos... Es en este contexto donde se presenta el gran reto de evaluar no sólo los procesos sino los productos creados desde la relación educación-tecnología.
En un principio, la tecnología se relacionó sólo con procesos productivos y bélicos; hoy, sin embargo, los adelantos superan estos ámbitos, desbordándose a muchos otros sectores, entre ellos, el de la educación.
Tradicionalmente, los procesos educativos formales se han realizado de manera presencial, siendo uno de los recursos predominantes, el libro. Aunque los libros no desaparecerán, no podemos cerrar los ojos frente a los avances que la tecnología provee; es así como se incorporan las herramientas digitales como medios educativos: CD-ROM, DVD y las redes que propician novedosas técnicas de educación no presencial.
Lo anterior obliga a los profesores y especialistas en el ámbito de la educación a utilizar estas nuevas herramientas, de manera que la exigencia para el profesor no se reduce ya al mero conocimiento de los libros y materiales impresos de cada especialidad, sino que ahora, además de ese conocimiento, requiere la utilización de las novedades tecnológicas.
Así como existen lineamientos para evaluar si un libro cumple o no con los objetivos estipulados en los programas, y si existe coherencia lógica y psicológica entre el material y el destinatario, de la misma manera los materiales digitales deberán evaluarse. Sin embargo, la vertiginosidad del avance tecnológico y la concreción de ésta en diversos tipos de software, ha desbordado el fenómeno de creación, superando su evaluación.
En un primer momento esto podría considerarse una deficiencia; no obstante, se presenta más bien como una oportunidad para profundizar en el campo de la evaluación. De esta reflexión se desprende la siguiente propuesta enca-minada a la evaluación de software educativo.
HACIA LA CONSTRUCCIÓN DE UN ESPACIO EUROPEO DE EDUCACIÓN SUPERIOR
Authors: Medina Martínez Sara Rosaura 
Published: October 2021

Universalmente se consideran de extrema importancia la educación y la cooperación educativa para el desarrollo de sociedades estables, pacíficas y democráticas.
Desde fines de los años ochenta, los ministros de educación superior de algunos países europeos, han buscado armonizar sus sistemas educativos para construir un espacio europeo de educación superior. Los esfuerzos por construir este campo de unidad educativa han sido fecundos. La idea ha dado fruto y numerosas naciones se han sumado al proceso. El papel de la Universidad como motor de desarrollo cultural se hace cada día más evidente.
EVALUACIÓN DE LA FUNCIONALIDAD INTERNA Y EXTERNA EN FAMILIAS URBANAS (DISTRITO FEDERAL Y ESTADO DE MÉXICO)1
Authors: López de LLergo Ana Teresa , Cruz de Galindo Luz María 
Published: October 2021

Este trabajo representa un acercamiento a la explicación de la funcionalidad –interna y externa– de 26 familias, de padres con hijos entre 12 y 15 años2, que cursan la educación media y pertenecen al ambiente urbano, de clase socioeconómica media, con ingresos que apenas satisfacen las necesidades básicas y cuyas diversiones son poco onerosas.
Para ello se elaboró un cuestionario (Anexo1). Consideramos que para conocer mejor a una familia, valía la pena contar con el punto de vista de dos de sus miembros: padre o madre y un hijo. Para obtener datos más confiables, varias preguntas guardan relación con un mismo tema (Anexo 2).
Partimos del presupuesto de que las familias poseen dos ámbitos de funcionalidad: el interno y el externo. Para contar con información sobre ellos obtuvimos, del texto La familia funcional 3, diez binomios. Cinco referidos a la educación familiar, en donde se analiza cómo es la funcionalidad interna de la familia, y cómo se proyecta al exterior. Éstos son: personal-impersonal; intimidad-apertura; orden-autonomía; aportación-aceptación; comunicación-aislamiento. En cada binomio existen dos posibilidades: el equilibrio o la polarización hacia uno u otro lado.
Los otros cinco binomios conciernen a las políticas familiares, y se manifiestan en la funcionalidad externa de la familia, cuya raíz está en su propio seno: sistemas concretos-sistemas abstractos; gobalización-regionalización; especializacióndiversificación de funciones; remuneración-no remuneración; democratización-centralización. También en cada uno existen dos posibilidades, según el caso.
ALGUNOS DESAFÍOS DEL SISTEMA EDUCATIVO MEXICANO ANTE LA GLOBALIZACIÓN
Authors: Castillo Sánchez Hidalgo Mario A. 
Published: October 2021

El escrito aborda la problemática que enfrenta el Sistema Educativo Mexicano ante la globalización. Se parte de dos líneas de análisis:
a) El sistema educativo mexicano.
b) La globalización.
En el texto se realiza una somera descripción de las dimensiones del sistema educativo mexicano y se comenta el proceso histórico que éste ha seguido. Posteriormente, se plantea el reto que la educación en México encara frente a la apertura que supone la globalización.
En una segunda línea de análisis, se describe la globalización en sus distinto ámbitos y se comenta cuáles han sido los factores que han catalizado este fenómeno; al mismo tiempo, se señalan cuáles son sus problemas y contradicciones.