bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Killer Cells Are Present in Rag1−/− Mice and Promote Tissue Damage During the Acute Phase of Ischemic Stroke
Authors: Rolfes Leoni , Ruck Tobias , David Christina , Mencl Stine , Bock Stefanie , Schmidt Mariella , Strecker Jan-Kolja , Pfeuffer Steffen , Mecklenbeck Andreas-Schulte , Gross Catharina , Gliem Michael , Minnerup Jens , Schuhmann Michael K. , Kleinschnitz Christoph , Meuth Sven G. 
Published: June 2021

AbstractRag1−/− mice, lacking functional B and T cells, have been extensively used as an adoptive transfer model to evaluate neuroinflammation in stroke research. However, it remains unknown whether natural killer (NK) cell development and functions are altered in Rag1−/− mice as well. This connection has been rarely discussed in previous studies but might have important implications for data interpretation. In contrast, the NOD-Rag1nullIL2rgnull (NRG) mouse model is devoid of NK cells and might therefore eliminate this potential shortcoming. Here, we compare immune-cell frequencies as well as phenotype and effector functions of NK cells in Rag1−/− and wildtype (WT) mice using flow cytometry and functional in vitro assays. Further, we investigate the effect of Rag1−/− NK cells in the transient middle cerebral artery occlusion (tMCAO) model using antibody-mediated depletion of NK cells and adoptive transfer to NRG mice in vivo. NK cells in Rag1−/− were comparable in number and function to those in WT mice. Rag1−/− mice treated with an anti-NK1.1 antibody developed significantly smaller infarctions and improved behavioral scores. Correspondingly, NRG mice supplemented with NK cells were more susceptible to tMCAO, developing infarctions and neurological deficits similar to Rag1−/− controls. Our results indicate that NK cells from Rag1−/− mice are fully functional and should therefore be considered in the interpretation of immune-cell transfer models in experimental stroke. Fortunately, we identified the NRG mice, as a potentially better-suited transfer model to characterize individual cell subset-mediated neuroinflammation in stroke.
The Regulation of Informal Trade Credit (Ograyi) in Afghanistan
Authors: Choudhury Nafay 
Published: June 2021

AbstractThis article explores the creation, circulation, and regulation of informal trade credit or “ograyi” in Afghanistan. The practice ofograyiallows businesses to access short-term credit, from either their suppliers or third parties, to acquire specified goods. This paper provides an account of the non-legal practices that regulateograyitransactions.Ograyivitally depends on the development of trust between parties. Clientelism helps to maintain stable relationships that can offset market unpredictability. Widespread market norms and practices establish the general behaviour of participants. Parties also renegotiate the terms of the contract if circumstances make it impossible for the creditor to repay the loan in the agreed timeframe. Furthermore, bank credit remains largely unavailable or unappealing to many businesses, and the legal system provides limited recourse in the case of contractual breach. Thus, the non-legal practices regulatingograyiserve as a substitute for legal coercion.
Developing a Context-Bound Model for Hospital Triage in Disasters and Mass Casualty Incidents in the Health System of Iran
Authors: Bazyar Jafar , Farrokhi Mehrdad , Salari Amir , Noroozi Mehdi , Khankeh Hamidreza 
Published: June 2021

AbstractObjective:The aim of this study was to develop a context-bound model of hospital triage in disasters and mass casualty incidents in the health system of Iran.Methods:This study was done using a sequential mixed method. Data were analyzed using Expert Choice software program.Results:In the qualitative phase, 27 specialists were interviewed. Walking and purposeful movement, airway and respiration, circulatory status, and mental indices were included in the finalized model. In the quantitative phase, 21 participants responded to a questionnaire for weighting and ranking the final indices based on 3 competing options, including clinical importance of the index, lack of complexity and simplicity in implementation, and speed of implementation. The index of walking and purposeful movements weighing 0.300 and ranking 1, airway and respiration weighing 0.276 and ranking 2, blood circulatory status weighing 0.245 and ranking 3, and finally mental status weighing 0.179 and ranking 4 were obtained.Conclusions:This is the first attempt to design and develop a new context-bound model of hospital triage in disasters and mass casualties in Iran. The development of new triage models is a dynamic and continuous process, and changes will be applied to them, in case further developments and improvements are required.
Self-Medication in the COVID-19 Pandemic: Survival of the Fittest
Authors: Rafiq Kiran , Nesar Shagufta , Anser Humaira , Leghari Qurat-ul-Ain , Hassan Alisha , Rizvi Alina , Raza Aleeza , Saify Zafar Saied 
Published: June 2021

AbstractObjective:After the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic, intense efforts to combat the novel coronavirus were undertaken, with many fatalities in most regions of the world. The high fatality rate and socioeconomic collapse affected the health of uninfected individuals because healthcare measures and scheduled clinical and hospital visits were avoided by people in an attempt to reduce their exposure to the contagion. The general population began self-medication practices as means to safeguard against exposure to the virus.Methods:The present study investigated the effectiveness of self-medication compliance among the general population. For this purpose, a questionnaire on the Zenodo scale was developed and adults and teen respondents were asked to complete it, after providing consent. The data gathered were analyzed using IBM SPSS Statistics Version 26.Results:The study amazingly found high compliance with self-medication among the focused population during the period of COVID-19. Estimated results showed a highly significant correlation of 0.000, P < 0.05, between the adaptation of self-medication and pandemic situation, which was estimated from chi-squared and Fisher test results.Conclusions:However, the fear of coronavirus made the practice, or malpractice, a survival of the fittest, innate ability of human nature.
Importance of Pharmacy Partnerships in Effective COVID-19 Vaccine Distribution
Authors: Pammal Rajkumar S. , Kreinces Jason B. , Pohlman Kevin L. 
Published: June 2021

AbstractThe goal of vaccinating the majority of Americans against coronavirus disease 2019 (COVID-19) in a timely manner requires a robust federal vaccine distribution plan involving pharmacy partnerships. Previously, the 2009 Centers for Disease Control and Prevention (CDC) H1N1 Vaccine Pharmacy Initiative resulted in approximately 10% of adults who received a vaccine during the 2009 pandemic reporting they were vaccinated at a pharmacy. This proportion has already largely increased for COVID-19 vaccinations, with the US Department of Health and Human Services (HHS) using similar channels for vaccination as existing partnerships with national pharmacy and grocery retail chains for the COVID-19 Community-Based Testing Program. It continues to prove crucial that the Biden administration’s national COVID-19 vaccine distribution plan, including the Federal Retail Pharmacy Program, focus on ensuring equitable vaccine distribution and access in medically underserved areas and to vulnerable populations, enabling maximum uptake of COVID-19 vaccines.
COVID-19: A Comprehensive Analysis of the Pandemic’s Effect on an Emergency Department
Authors: Flamm Avram , Lee Alexander , Mencl Francis 
Published: June 2021

AbstractObjective:Coronavirus disease 2019 (COVID-19, caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) is a historic pandemic severely impacting health care. This study examines its early effect on a busy academic emergency department.Methods:A retrospective analysis of patients from an academic tertiary care Level I trauma, cardiac and stroke center’s emergency department seeing an average of 54,000 adults and 21,000 pediatric patients per year. Total visits, reasons for patient visits, demographics, disposition, and length of stay were analyzed from January through July 2020 and compared with the same time period in the previous 2 y.Results:From March through July 2020 there were statistically significant decreases in the total number of patient visits (-47%) especially among pediatric (-73%) and elderly (-43%) patients and those with cardiovascular (-39%), neurological (-63%) complaints, headaches (-60%), back pain (-64%), abdominal pain (-51%), and minor trauma (-71%). There was, however, a significant increase in pulmonary complaints (+54%), as well as admissions (+32%), and length of stay (+40%).Conclusions:There was a significant drop in overall patients and select groups early in the pandemic, while admissions and emergency department length of stay both increased. This has implications for future pandemic planning.
The Usefulness of Shock Index and Modified Shock Index in Predicting the Outcome of COVID-19 Patients
Authors: Kurt Erdem , Bahadirli Suphi 
Published: June 2021

AbstractObjective:The aim of this study is to investigate the accuracy of shock index (SI) and modified shock index (mSI) in predicting the intensive care unit (ICU) requirement and in-hospital mortality among coronavirus disease (COVID-19) patients who are admitted to the emergency department (ED). Likewise, the effects of patients’ conditions such as age, gender, and comorbidity on prognosis will be analyzed.Methods:The files were retrospectively scanned for all COVID-19 patients over the age of 18 years who were admitted to the ED and hospitalized between January 1, 2021, and March 15, 2021. The area under the receiver operating characteristic curve and the area under the curve (AUC) were used to assess each scoring system discriminatory for predicting in-hospital mortality and ICU admission.Results:There were 464 patients included in this study. The mean age of the patients was 62.4 ± 16.7, of which 245 were men and 219 were women. The most common comorbidity in patients was hypertension (200; 43.1%), followed by chronic obstructive pulmonary disease (174; 37.5%), and coronary artery disease (154; 33.2%). In terms of in-hospital mortality, the AUC of SI, and mSI were 0.719 and 0.739, respectively. In terms of an ICU requirement, the AUC of SI, and mSI were 0.704 and 0.729, respectively.Conclusion:In this study, it was concluded that SI and mSI are useful in predicting in-hospital mortality and ICU requirement in COVID-19 patients. In addition, another important result of the study is that advanced age, male gender, and hypertension may be associated with a poor prognosis.
Two Sources for Abu Dhuʾayb al-Hudhali's Famous Elegy
Authors: Hussein Ali Ahmad 
Published: June 2021

AbstractThis article considers the celebrated elegy by the classical 7th-century Arabic poet, Abu Dhuʾayb al-Hudhali — his ʿayniyya, which ends with ʿayn as a rhyming letter. Analyzing the poem's structure and comparing it with that of two poems composed by Abu Dhuʾayb's teacher, Saʿida b. Juʾayya al-Hudhali, leads to the conclusion that Saʿida's two poems were the main sources on which the pupil drew to create his poem. The sophisticated changes that Abu Dhuʾayb introduced in structure and content, however, made his poem more memorable than those of his teacher. The article raises another question, to which there is, as yet, no definitive answer: what was the true inspiration for Abu Dhuʾayb's poem? Was it the death of his sons, as is traditionally believed, or was it literary: to surpass his teacher in composing a more skillful poem?
Pandemics and Political Development
Authors: Gingerich Daniel W. , Vogler Jan P. 
Published: June 2021

ABSTRACTDo pandemics have lasting consequences for political behavior? The authors address this question by examining the consequences of the deadliest pandemic of the last millennium: the Black Death (1347–1351). They claim that pandemics can influence politics in the long run if the loss of life is high enough to increase the price of labor relative to other factors of production. When this occurs, labor-repressive regimes, such as serfdom, become untenable, which ultimately leads to the development of proto-democratic institutions and associated political cultures that shape modalities of political engagement for generations. The authors test their theory by tracing the consequences of the Black Death in German-speaking Central Europe. They find that areas hit hardest by that pandemic were more likely to adopt inclusive political institutions and equitable land ownership patterns, to exhibit electoral behavior indicating independence from landed elite influence during the transition to mass politics, and to have significantly lower vote shares for Hitler’s National Socialist Party in the Weimar Republic’s fateful 1930 and July 1932 elections.
Consistency analysis of global positioning system position errors with typical statistical distributions
Authors: Specht Mariusz 
Published: June 2021

AbstractResearch into statistical distributions ofφ,λand two-dimensional (2D) position errors of the global positioning system (GPS) enables the evaluation of its accuracy. Based on this, the navigation applications in which the positioning system can be used are determined. However, studies of GPS accuracy indicate that the empiricalφandλerrors deviate from the typical normal distribution, significantly affecting the statistical distribution of 2D position errors. Therefore, determining the actual statistical distributions of position errors (1D and 2D) is decisive for the precision of calculating the actual accuracy of the GPS system. In this paper, based on two measurement sessions (900,000 and 237,000 fixes), the distributions of GPS position error statistics in both 1D and 2D space are analysed. Statistical distribution measures are determined using statistical tests, the hypothesis on the normal distribution ofφandλerrors is verified, and the consistency of GPS position errors with commonly used statistical distributions is assessed together with finding the best fit. Research has shown thatφandλerrors for the GPS system are normally distributed. It is proven thatφandλerrors are more concentrated around the central value than in a typical normal distribution (positive kurtosis) with a low value of asymmetry. Moreover,φerrors are clearly more concentrated thanλerrors. This results in larger standard deviation values forφerrors thanλerrors. The differences in both values were 25–39%. Regarding the 2D position error, it should be noted that the value of twice the distance root mean square (2DRMS) is about 10–14% greater than the value of R95. In addition, studies show that statistical distributions such as beta, gamma, lognormal and Weibull are the best fit for 2D position errors in the GPS system.
Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests
Authors: De Marco Verissimo Carolina , O'Brien Carol , López Corrales Jesús , Dorey Amber , Cwiklinski Krystyna , Lalor Richard , Doyle Jack M. , Field Stephen , Masterson Claire , Ribes Martinez Eduardo , Hughes Gerry , Bergin Colm , Walshe Kieran , McNicholas Bairbre , Laffey John G. , Dalton John P. , Kerr Colm , Doyle Sean 
Published: June 2021

AbstractThe novel coronavirus, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is the causative agent of the 2020 worldwide coronavirus pandemic. Antibody testing is useful for diagnosing historic infections of a disease in a population. These tests are also a helpful epidemiological tool for predicting how the virus spreads in a community, relating antibody levels to immunity and for assessing herd immunity. In the present study, SARS-CoV-2 viral proteins were recombinantly produced and used to analyse serum from individuals previously exposed, or not, to SARS-CoV-2. The nucleocapsid (Npro) and spike subunit 2 (S2Frag) proteins were identified as highly immunogenic, although responses to the former were generally greater. These two proteins were used to develop two quantitative enzyme-linked immunosorbent assays (ELISAs) that when used in combination resulted in a highly reliable diagnostic test. Npro and S2Frag-ELISAs could detect at least 10% more true positive coronavirus disease-2019 (COVID-19) cases than the commercially available ARCHITECT test (Abbott). Moreover, our quantitative ELISAs also show that specific antibodies to SARS-CoV-2 proteins tend to wane rapidly even in patients who had developed severe disease. As antibody tests complement COVID-19 diagnosis and determine population-level surveillance during this pandemic, the alternative diagnostic we present in this study could play a role in controlling the spread of the virus.
Atom Probe Analysis of Nanoparticles Through Pick and Coat Sample Preparation
Authors: Josten Jan P , Felfer Peter J 
Published: June 2021

Abstract
The ability to analyze nanoparticles in the atom probe has often been limited by the complexity of the sample preparation. In this work, we present a method to lift–out single nanoparticles in the scanning electron microscope. First, nanoparticles are dispersed on a lacey carbon grid, then positioned on a sharp substrate tip and coated on all sides with a metallic matrix by physical vapor deposition. Compositional and structural insights are provided for spherical gold nanoparticles and a segregation of silver and copper in silver copper oxide nanorods is shown in 3D atom maps. Using the standard atom probe reconstruction algorithm, data quality is limited by typical standard reconstruction artifacts for heterogeneous specimens (trajectory aberrations) and the choice of suitable coatings for the particles. This approach can be applied to various unsupported free-standing nanoparticles, enables preselection of particles via correlative techniques, and reliably produces well-defined structured samples. The only prerequisite is that the nanoparticles must be large enough to be manipulated, which was done for sizes down to ~50 nm.
Traumatic events and psychotic experiences: a nationally representative study in Thailand
Authors: Kilian C. , Supanya S. , Probst C. , Morgan C. , Bärnighausen T. , Kittirattanapaiboon P. , Kwansanit P. , Reininghaus U. ,   for the Thai Mental Health Survey Working Group
Published: June 2021

Abstract

Aims
Most research exploring the link between traumatic events and psychotic experiences has focused on either Australia, Europe or North America. In this study, we expand the existing knowledge to Thailand and investigate the impact of the type and the number of traumatic events on psychotic experiences in Thailand.

Methods
We used data from the nationally representative 2013 Thai National Mental Health Survey (TNMHS), including questions on traumatic events and psychotic experiences. We regressed the lifetime experience of hallucinations or delusions against the following independent variables: the experience of any traumatic event during lifetime (dichotomous; hypothesis 1); the experience of either no traumatic event, one interpersonal, one unintentional or both interpersonal and unintentional traumatic events (categorical; hypothesis 2) and the number of traumatic events experienced during lifetime (categorical; hypothesis 3). We adjusted the regression models for sociodemographic indicators and psychiatric disorders, and considered survey weights.

Results
About 6% (95% confidence interval: 4.9–7.0) of the respondents stated that they had either hallucinatory or delusional experiences during their lifetime. The risk of reporting such experiences was more than doubled as high among respondents who had experienced at least one traumatic event during their lifetime than among those who had not yet experienced one, with higher risks for interpersonal or multiple traumatic events. Our results further indicated an increase in the risk of psychotic experiences as the number of traumatic events increased, with up to an eight-fold higher risk for people exposed to five or more traumatic events in their lifetime, compared to those with no traumatic events.

Conclusions
Individuals reporting interpersonal or multiple traumatic events face much higher risk of psychotic experiences. Effective and widely accessible secondary prevention programmes for people having experienced interpersonal or multiple traumatic events constitute a key intervention option.
Evaluation of the Drivers Responsible for Flooding in Africa
Authors: Tramblay Yves , Villarini Gabriele , El Khalki El Mahdi , Gründemann Gaby , Hughes Denis 
Published: June 2021

AbstractAfrica is severely affected by floods, with an increasing vulnerability to these events in the most recent decades. Our improved preparation against and response to this hazard would benefit from an enhanced understanding of the physical processes at play. Here, a database of 399 African stream gauges is used to analyze the seasonality of observed annual maximum flood, precipitation and soil moisture between 1981 and 2018. The database includes a total of 11,302 flood events, covering most African regions. The analysis is based on directional statistics to compare the annual maximum river flood with annual maximum rainfall and soil moisture. The results show that the annual maximum flood in most areas is more strongly linked to the annual peak of soil moisture than of annual maximum precipitation. In addition, the interannual variability of flood magnitudes is better explained by the variability of annual maximum soil moisture than by the variability in the annual maximum precipitation. These results have important implications for flood forecasting and the analysis of the long‐term evolution of these hydrological hazards in relation with their drivers.
Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health
Authors: O’Loughlin Jessica , Casanova Francesco , Jones Samuel E. , Hagenaars Saskia P. , Beaumont Robin N. , Freathy Rachel M. , Watkins Edward R. , Vetter Céline , Rutter Martin K. , Cain Sean W. , Phillips Andrew J. K. , Windred Daniel P. , Wood Andrew R. , Weedon Michael N. , Tyrrell Jessica 
Published: June 2021

AbstractLate diurnal preference has been linked to poorer mental health outcomes, but the understanding of the causal role of diurnal preference on mental health and wellbeing is currently limited. Late diurnal preference is often associated with circadian misalignment (a mismatch between the timing of the endogenous circadian system and behavioural rhythms), so that evening people live more frequently against their internal clock. This study aims to quantify the causal contribution of diurnal preference on mental health outcomes, including anxiety, depression and general wellbeing and test the hypothesis that more misaligned individuals have poorer mental health and wellbeing using an actigraphy-based measure of circadian misalignment. Multiple Mendelian Randomisation (MR) approaches were used to test causal pathways between diurnal preference and seven well-validated mental health and wellbeing outcomes in up to 451,025 individuals. In addition, observational analyses tested the association between a novel, objective measure of behavioural misalignment (Composite Phase Deviation, CPD) and seven mental health and wellbeing outcomes. Using genetic instruments identified in the largest GWAS for diurnal preference, we provide robust evidence that early diurnal preference is protective for depression and improves wellbeing. For example, using one-sample MR, a twofold higher genetic liability of morningness was associated with lower odds of depressive symptoms (OR: 0.92, 95% CI: 0.88, 0.97). It is possible that behavioural factors including circadian misalignment may contribute in the chronotype depression relationship, but further work is needed to confirm these findings.