bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular Endothelial Growth Factor-A is an Immunohistochemical Biomarker for the Efficacy of Bevacizumab-containing Chemotherapy for Duodenal and Jejunal Adenocarcinoma
Authors: Amano Takahiro , Iijima Hideki , Shinzaki Shinichiro , Tashiro Taku , Iwatani Shuko , Tani Mizuki , Otake Yuriko , Yoshihara Takeo , Sugimoto Aya , Egawa Satoshi , Yamaguchi Shinjiro , Kinoshita Kazuo , Araki Manabu , Hirao Motohiro , Sakakibara Yuko , Hiyama Satoshi , Ogawa Hiroyuki , Nagaike Koji , Murata Jun , Komori Masato , Okuda Yorihide , Kizu Takashi , Tsujii Yoshiki , Hayashi Yoshito , Inoue Takahiro , Takahashi Hidekazu , Mizushima Tsunekazu , Morii Eiichi , Takehara Tetsuo 
Published: April 2021

Abstract
Background: The efficacy and safety of bevacizumab-containing chemotherapy for patients with metastatic duodenal and jejunal adenocarcinoma (mDJA) are unclear. The present study aimed to evaluate the efficacy of bevacizumab and to explore immunohistochemical markers that can predict the efficacy of bevacizumab for patients with mDJA.Methods: This multicentre study included patients with histologically confirmed small bowel adenocarcinoma who received palliative chemotherapy from 2008 to 2017 at 15 hospitals. Immunostaining was performed for vascular endothelial growth factor A (VEGF-A), TP53, Ki67, β-catenin, CD10, MUC2, MUC5AC, MUC6, and mismatch repair proteins.Results: A total of 74 patients were enrolled, including 65 patients with mDJA and 9 with metastatic ileal adenocarcinoma. Patients with mDJA who received platinum-based chemotherapy with bevacizumab as first-line treatment tended to have a longer progression-free survival and overall survival than those treated without bevacizumab (P = 0.075 and 0.077, respectively). Multivariate analysis extracted high VEGF-A expression as a factor prolonging progression-free survival (hazard ratio: 0.52, 95% confidence interval: 0.30-0.91). In mDJA patients with high VEGF-A expression, those who received platinum-based chemotherapy with bevacizumab as a first-line treatment had significantly longer progression-free survival and tended to have longer overall survival than those treated without bevacizumab (P = 0.025 and P = 0.056, respectively), whereas no differences were observed in mDJA patients with low VEGF-A expression. Conclusion: Immunohistochemical expression of VEGF-A is a potentially useful biomarker for predicting the efficacy of bevacizumab-containing chemotherapy for patients with mDJA.
Feasibility And Availability of Standard-Sized Cup At The True Acetabulum In Acetabular Reconstruction of Crowe Type IV Hip Dysplasia
Authors: Yang Yuhui , Ma Yuanchen , Li Qingtian , Liao Junxing , Dong Hang , Zheng Qiujian 
Published: April 2021

Abstract
Background: This study aimed to investigate the morphological features and 2D/3D coverage parameters of the true acetabulum of Crowe type IV hips and to identify the optimal component center of standard-sized cup implantation.Methods: A total of 42 Crowe IV hips in 37 patients and 36 normal hips were included in the present study. Based on 3D reconstruction, anatomy and volume of the true acetabulum were measured quantitatively. Through simulated implantation, the feasibility of standard-sized cup implantation was evaluated by cup-based morphological assessments and coverage parameters. Eventually, bony landmarks for optimal component center location were determined. Mean follow-up was 4.7 years (1.2 to 6.3 years).Results: All the dysplastic hips were placed with standard-size acetabular implant (44.67mm, 44 to 48mm) successfully, with no acetabular implant loosening during the follow-up period. Compared with control group, the dysplastic acetabulum was more anteverted and abductive, with a thicker medial wall. According to the true acetabulum, bone stock is relatively sufficient in the posterior direction and prominently deficient in the anterosuperior and superior direction. Average 3D component coverage can reach 79.89% by standard-sized cup implantation at the true acetabulum. Regarding the component opening plane, the optimal component center located at the midpoint between the superolateral and posteroinferior point of the true acetabulum. Conclusion: Standard cup implantation is feasible and available in Crowe IV hip at the true acetabulum. The optimal component center was determined to be relatively constant based on the useful bony landmarks.Level of evidence: Therapeutic Level 3b.
Antenatal Care Services and Preparedness of Health Facilities in Bangladesh: Evidence From Two Nationally Representative Surveys
Authors: Hakim Shariful , Chowdhury Muhammad Abdul Baker , Ahmed Zobayer , Uddin Md Jamal 
Published: April 2021

Abstract
ObjectiveTo assess whether health facilities in Bangladesh are prepared to provide ANC services and to investigate facility characteristics that are linked to preparedness.Methods This cross-sectional analysis used publicly available data from two waves of Bangladesh Health Facilities Survey (BHFS) that was conducted in 2014 and 2017 using stratified random sample of facilities. 1508 and 1506 health facilities were included as study samples from the 2014 and 2017 BHFS respectively. The outcome variable ‘ANC services preparedness’ was calculated as an index score using a group of tracer indicators. Multivariable logistic regression models were used to identify the important correlates of ANC service preparednessResultsThe percentage of facilities providing ANC services has increased slightly from 97.4% in 2014 to 98.8% in 2017. Union level public facilities were less likely to be prepared for providing ANC service than district level public facilities in 2014 (Odds ratio (OR): 0.20, Confidence interval (CI): 0.08-0.50, P-value=<0.001). Similar results were also found in 2017 (OR: 0.14, CI: 0.06-0.33, P-Value=<0.001). The facilities with high basic amenities score were more likely to be prepared for providing ANC than the facilities with low basic amenities score in 2014 (OR: 2.52, CI: 1.02-6.12, P-Value=0.04) and in 2017 (OR: 1.79, CI: 1.08-2.99, P-Value=0.02). Conclusion The overall preparedness score to offer ANC service was also poor. Our findings may be considered for not only health planning but also decision making in order to produce a healthy mother and a baby at the end of pregnancy.
SARS-CoV-2 Infection Elicits a Greater Humoral Immune Response in the Second Wave Than the First Wave
Authors: Ezzikouri Sayeh , Majidi Hind , Redwane Soad , Meziane Nadia , Zahir Abdellatif , Abbadi Islam , Zerrad Chaimaa , Haddaji Asmaa , Abounouh Karima , Hilmi Soufiane , Aqillouch Safaa , Elmessaoudi-Idrissi Mohcine , Laazaazia Oumaima , Ainahi Abdelhakim , Rmili Nabila , Maaroufi Abderrahmane , Benjelloun Soumaya 
Published: April 2021

Abstract
PurposeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing pandemic of coronavirus disease 2019 (COVID-19). One year has passed since the first COVID-19 case, and concerns have emerged regarding new variants, meaning that characterizing antibody-mediated immune response dynamics is of paramount importance. Here, we evaluated the humoral immune response against SARS-CoV-2 in subjects during the first and second waves of the pandemic in Morocco. MethodsWe assessed humoral immune response in samples from 94 seropositive individuals in the first wave (February to August 2020) and 596 seropositive individuals in the second wave (December 2020 to January 2021). Plasma samples were collected from volunteer blood donors and their levels of serum IgG to SARS-CoV-2 nucleoprotein (NP) were determined using architect SARS-CoV-2 IgG chemiluminescence microparticle immunoassay.ResultsOur results revealed an increase of humoral immunity during the second wave than first wave (3.897 ± 0.079 vs. 2.842 ± 0.153, respectively, p<0.0001). Notably, we found an age-related gradient in antibody level, with higher antibody index in subjects at 45 years old and above (p= 0.01451). However, no significant difference was found according to gender (p= 0.8629). ConclusionsOur data highlighted an important issue regarding antibody-mediated immune response against SARS-CoV-2 infection during the second wave and this issue might have arisen due to the dynamics of different strains circulating during the progress of the pandemic.
Targeting Positive Cofactor 4 induces autophagic cell death in MYC-expressing diffuse large B cell lymphoma
Authors: Ma Le , Gong Qiang , Chen Zelin , Wang Yu , Tan Xu , Liu Yunsheng , Wang Yawei , Liu Gaoyu , Fu Jianlin , Xie Mingling , Luo Peng , Chen Jieping , Shi Chunmeng 
Published: April 2021

Abstract
Background: The MYC-expressing diffuse large B-cell lymphoma (DLBCL) is one of the refractory lymphomas. The pathogenesis of MYC-expressing DLBCL is still unclear, and there is a lack of effective therapy. In this study, we have explored the clinical significance and the molecular mechanisms of transcription co-activator 4 (PC4) in MYC-expressing DLBCL.Methods: We investigated PC4 expression in 54 cases of DLBCL patients’ tissues and matched normal specimens, and studied the molecular mechanisms of PC4 in MYC-expressing DLBCL both in vitro and in vivo.Results: We reported for the first time that targeting c-Myc could induce autophagic cell death in MYC-expressing DLBCL cell lines. We next characterized that PC4 was an upstream regulator of c-Myc, and PC4 was overexpressed in DLBCL and was closely related to clinical staging, prognosis and c-Myc expression. Further, our in vivo and in vitro studies revealed that PC4 knockdown could induce autophagic cell death of MYC-expressing DLBCL. And inhibition of c-Myc mediated aerobic glycolysis and activation of AMPK / mTOR signaling pathway were responsible for the autophagic cell death induced by PC4 knockdown in MYC-expressing DLBCL. Through the CHIP, DLRTM and EMSA assay, we also found that PC4 exerted its oncogenic functions by directly binding to c-Myc promoters.Conclusions: PC4 exerts its oncogenic functions by directly binding to c-Myc promoters. Inhibition of PC4 can induce autophagic cell death of MYC-expressing DLBCL. Our study provides novel insights into the functions and mechanisms of PC4 in MYC-expressing DLBCL, and suggests that PC4 might be a promising therapeutic target for MYC-expressing DLBCL.
Boosting proton reduction via isolated Cu atoms in Bi lattice for efficient electroreduction of CO2 to formate
Authors: Luo Pei-Pei , Wang Hong-Juan , Li Lina , Nan Bing , Li Yu , Lu Tongbu 
Published: April 2021

Abstract
Current Bi-based catalysts suffer from low current density for electroreduction of CO2 to formate due to the high energy barrier of H+ reduction to *H on Bi sites. Here we report a unique BiCu single-atom alloy catalyst (SAAC) that can deliver a ultrahigh formate partial current density (jformate) of 434 mA cm–2, the highest among the reported Bi-based electrocatalysts to date, with a formate Faradaic efficiency (FEformate) of 96.5% at –0.55 V (vs. RHE) in a flow cell, while BiCu alloy catalyst containing Cu nanoclusters can only deliver a jformate of 48.5 mA cm–2 with a FEformate of 37.3% under an identical condition. Mechanism investigations reveal that the isolated single-atom Cu in BiCu SAAC can dramatically reduce the energy barrier of H+ reduction to *H on Cu site for boosting the reduction of CO2 to formate. Our work provides a new strategy for engineering unfavourable energy barrier of electrocatalysts to promote CO2 reduction.
Determination of Reasonable Width of Filling Body for Gob-Side Entry Retaining in Mining Face With Large Cutting Height
Authors: Pu Shijiang , Wu Gui yi , Liu Qinzhi , Wang Yuliang , Li Qiang , Xiong Yu 
Published: April 2021

Abstract
When gob-side entry retaining is adopted in mining face with large cutting height, due to large stope space, strong dynamic pressure and other reasons, the filling body is usually broken and unstable due to improper width of filling body, and the stability of surrounding rock of roadway is poor. Therefore, this paper will take Shaqu mine as the engineering background to study the reasonable filling body width of gob-side entry retaining in mining face with large cutting height. Firstly, the stability factors of gob-side entry retaining in mining face with large cutting height are analyzed, and the mechanical model of bearing structure of gob-side entry retaining is established based on the lateral pressure and overlying load of filling body, and the reasonable width of filling body is obtained quantitatively; Numerical simulation is used to analyze the evolution of vertical stress, vertical displacement and plastic zone of working face with the change of filling body width. Finally, combined with the deformation observation results of 24207 gob-side entry retaining roof, two sides and filling body, the rationality of filling body width is verified. The results show that: the setting of the width and strength of the filling body plays an important role in the stability of gob-side entry retaining. According to the mechanical model, the minimum width of the filling body is 2.2m in the lateral direction and 3.9m in the vertical direction; Numerical simulation shows that when the width of filling body is too small, with the increase of filling body width, the vertical stress of filling body increases gradually. When the width of filling body reaches a certain value, the vertical stress decreases with the increase of width, and the stress concentration area will change from symmetrical type to eccentric load type, from the middle of filling body to the side of filling body near gob. If the width of the filling body is too small, the filling body will be too broken to bear the load, resulting in too small vertical stress and too large vertical displacement of the roadway roof. The larger the width of the filling body is, the greater the cutting resistance is, the more timely the side roof of the gob can be cut off, the less the stress of the roadway and the filling body, and the more stable the retained roadway is. Finally, through the observation of 24207 gob-side entry retaining, the total deformation of two sides and roof and floor of roadway tends to be stable after 665mm and 597mm respectively. The roof of roadway does not appear severe subsidence and obvious cracking, and the floor does not appear too large floor heave. The effect of roadway retaining is good, which indicates that 4m support can meet the needs of practical engineering.
Metabolic Profile of Goats Fed Diets Containing Crude Glycerin from Biodiesel Production
Authors: Bezerra Higor , Santos Edson , Carvalho Gleidson , Oliveira Juliana , Silva Fabiano , Cassuce Meiry , Guerra Ricardo , Pereira Danillo , Pinho Ricardo , Perazzo Alexandre , Ferreira Daniele , Nascimento Thiago , Zanine Anderson 
Published: April 2021

Abstract
Background: Feedlot finishing of goats is a growing practice, but the economic viability of this technology is compromised by the inclusion of ingredients such as corn and soybean. An alternative to minimize this barrier is the use of agroindustry coproducts as substitutes for those ingredients, such as crude glycerolObjective: This study aimed to assess the effect of crude glycerin from biodiesel production in the feed of finishing Boer crossbred goats. Method: Thirty-two crossbred, castrated goat of age were distributed in a fully randomized experimental design with four treatments and eight replicates. The experiment lasted 69 days, and goats were fed sorghum silage and concentrate, with the inclusion of crude glycerin in the diet at levels of 0, 50, 100, and 150 g/kg on a dry matter basis. Result: The diets did not have an effect (p > 0.05) on the serum urea levels. Increasing dietary crude glycerin levels did not the influence the metabolic or urinary profiles or the kidney tissue (p > 0.05). The liver tissue of the goats fed diets containing the highest crude glycerin inclusion levels showed deleterious effects. Conclusion: The inclusion of crude glycerin with approximately 6.6 g/kg methanol caused deleterious effects to the liver tissue of Boer crossbred goats as the glycerin concentrations increased. However, glycerin levels did not cause deleterious effects on the kidney tissue or on the serum or urinary profiles. The use of crude glycerin with lower methanol content is recommended for goat diets.
Presenting IgG4-related disease: an emerging entity in Pakistan
Authors: Jafri Lena , Khawaja Sadori , Hashmi Bilal , Fatima Saira , Parkash Om , Khan Aysha Habib 
Published: April 2021

Abstract
Background

IgG4 related disease (IgG4-RD) is a spectrum of immune mediated disorder involving various organs of the body. In this study the clinical spectrum of possible IgG4-RD was explored.
Methods

Subjects tested for serum IgG4 and all biopsies of subjects with suspected IgG4-RD received at the clinical laboratory of a tertiary care hospital from April 2015 to December 2019 were included. Medical charts of subjects registered were reviewed and telephonic interviews were conducted. Subjects were divided into two groups: group I had biochemical evidence of IgG4-RD while group II had histopathological evidence of IgG4-RD. “Comprehensive diagnostic criteria for IgG4-RD, 2011” was used for labeling patients as possible, probable and definitive IgG4-RD.
Results

A total of 177 study subjects were recruited in the current study. Group I included 10 children and 105 adults whereas group II had 5 children and 57 adults. Out of the total 177 subjects definitive, probable and possible IgG4-RD were seen in (n = 2, 1.1%), (n = 61, 34.4%) and (n = 114, 64.4) subjects respectively. The commonest organs involved in all the study subjects were pancreas (57.6%), submandibular gland (12.4%) and liver (6.2%).
Conclusion

The clinical feature of IgG4-RD include single or multiple organ involvement with pancreas being the most frequently affected organ in the current population. Amalgamation of clinical, biochemical and histopathological findings are essential for the IgG4-RD, although none is pathognomonic by itself.
Validity of Procalcitonin as a Single Biomarker for Predicting Mortality in Pediatric Patients after Acute Traumatic or Post-Surgical Infections: A Retrospective Study
Authors: Albuali Waleed 
Published: April 2021

Abstract
Background Procalcitonin (PCT) levels are elevated in pediatric patients with systemic inflammation. This study was aimed to evaluate the use of Procalcitonin as a single biomarker in the prediction of mortality in pediatric patients after acute traumatic events or post-surgical infection.MethodsThis retrospective longitudinal study involved pediatric patients aged more than two weeks who were admitted to Pediatric Intensive Care Unit (PICU) of King Fahd Hospital of the University from January 2017 to December 2019 due to post-surgical infection. The data includes age, gender, comorbidity, severity of trauma, Pediatric Risk of Mortality Score (PRISM III) score in 24h of admission, PCT level at 24h and 48-72h, day-5 admission, blood culture, PICU stay, multi-organ failure, number of inotropes and intubation requirement were retrieved.ResultsThe mortalities after surgical infection was of 15.9%. Significantly, the elevated mean levels including PRISM III score, PCT level at 24h, 48-72h and day-5 admission were found in patients who were expired during their hospital stay. The PCT level at 48-72h was 0.89 (best cutoff point >1.35) revealed as highly predictive validity of PCT compared to PCT level at 24h which was 0.76 (best cutoff point >0.15) respectively.ConclusionThe serum PCT level as a single laboratory biomarker is remarkably useful in the prediction of mortality after surgical infection for commencing of an earliest treatment plan as a lifesaving attempt. A blended approach based on the PCT level with other clinical biomarkers can be developed for monitoring a treatment given.
Mental Health, Resilience and Sports Activity in the Initial Phase of The First COVID-19 Lockdown in Germany
Authors: Strahler Jana , Smolinski Konrad , Krüger Karsten , Krüger Britta 
Published: April 2021

Abstract
Background

Quarantine and social-distancing measures during the COVID-19 pandemic situation resulted in a radical change in lifestyle behaviors. While the reduction of total physical activity is assumed to negatively impact psychological health (higher stress and anxiety levels), regular sports activity during lockdown conditions has beneficial effects on health. Mechanisms are however unclear. The present analysis therefore examined the associations of sports activity with mental health, and assessed whether this is due to a direct effect on experiencing positive emotions and mental health, due to a stress-buffering mechanism, and/or through protecting/enhancing resilience.
Methods

An online survey, accessible from April 7th to April 30th 2020, gathered data on sports activity (Physical Activity, Exercise, and Sport Questionnaire, BSA), mental health (Patient Health Questionnaire-4, PHQ-4, WHO Wellbeing Index, WHO-5), momentary stress (single item), and resilience (i.e. feeling determined, cheerful, content, and being interested in the things one is doing). The final data set comprised 742 subjects including 534 (72.0%) women and ranging in age from 16 to 83 years (mean: 28.13 ± 11.46 years).
Results

Across all participants, sports activity was related to higher wellbeing and resilience but lower affective psychopathology. Importantly, all coefficients were below 0.2 indicating only small-sized associations. Moderation analyses confirmed a direct effect of sports activity on affective symptoms and wellbeing. Stress-buffering effects were not confirmed for either outcome but a resilience-protecting effect was seen for both wellbeing and affective psychopathology.
Conclusions

During the initial phase of the first COVID-19 lockdown, sports activity was associated with better mental health and wellbeing. Besides this direct effect, there was also evidence for a resilience-protecting effect of sport. The assumed stress-buffering effect could not be confirmed. Present findings indicate resilience-protective mechanisms to be a major contributor to sports beneficial effects on mental health during quarantine. Though, results from this cross-sectional, predominantly female, and convenience sample study must be confirmed in more diverse samples.
Differential Sensitivities of Electricity Consumption to Global Warming Across Regions of Argentina
Authors: Propatoa Tamara S. , Abelleyra Diego de , Semmartin Maria , Verón Santiago R 
Published: April 2021

Abstract
The description of the relationship between temperature (T) and electricity consumption (EC) is key to improve our understanding of a potential climate change amplification feedback and, thus, energy planning. We sought to characterize the relationship between the EC and daily T of different regions of Argentina and use these historical relationships to estimate expected EC under T future scenarios. We used a time series approach to model, remove trends and seasonality of EC accounting for breaks and discontinuities. EC and T data were obtained from Argentine Wholesale Market Administrator Company and global databases, respectively. We evaluated the T-EC model for the period between 1997 and 2014 and two sub-periods: 1997–2001 and 2011–2014. We used modelled temperature projections for the 2027–2044 period based on the Representative Pathway Concentration 4.5 together with our region specific T-EC models to predict changes in EC due to T changes. The shape of the T-EC relationships was quite stable between periods and regions but varied according to the temperature gradient. We found large increases in EC in warm days (from 40 to 126 Wh/cap/ºC) and a region specific response to cold days (from flat to steep responses). The T at which EC was minimum varied between 14 and 20°C and increased in time as mean daily T also increased. Estimated temperature projections translate into an average increase factor of 7.2 in EC with contrasting relative importance between regions of Argentina. Results highlight potential sensitivity of EC to T in the developing countries.