bluuebunny/crossref_metadata_2025_split huggingface dataset:
Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice
Authors: Mungunsukh Ognoon , George Jeffy , McCart Elizabeth A , Snow Andrew L , Mattapallil Joseph J , Mog Steven R , Panganiban Ronald Allan M , Bolduc David L , Rittase W Bradley , Bouten Roxane M , Day Regina M 
Published: February 2021

ABSTRACT
The lung is sensitive to radiation and exhibits several phases of injury, with an initial phase of radiation-induced pneumonitis followed by delayed and irreversible fibrosis. The angiotensin-converting enzyme inhibitor captopril has been demonstrated to mitigate radiation lung injury and to improve survival in animal models of thoracic irradiation, but the mechanism remains poorly understood. Here we investigated the effect of captopril on early inflammatory events in the lung in female CBA/J mice exposed to thoracic X-ray irradiation of 17–17.9 Gy (0.5–0.745 Gy min–1). For whole-body + thoracic irradiation, mice were exposed to 7.5 Gy (0.6 Gy min–1) total-body 60Co irradiation and 9.5 Gy thoracic irradiation. Captopril was administered orally (110 mg kg–1 day–1) in the drinking water, initiated 4 h through to150 days post-irradiation. Captopril treatment increased survival from thoracic irradiation to 75% at 150 days compared with 0% survival in vehicle-treated animals. Survival was characterized by a significant decrease in radiation-induced pneumonitis and fibrosis. Investigation of early inflammatory events showed that captopril significantly attenuated macrophage accumulation and decreased the synthesis of radiation-induced interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) pro-inflammatory cytokines in the lungs of irradiated mice. Suppression of IL-1β and TNF-α correlated with an increase of the anti-inflammatory cytokine IL-10 in the spleen with captopril treatment. We also found that captopril decreased markers for radiation-induced accelerated senescence in the lung tissue. Our data suggest that suppression of inflammation and senescence markers, combined with an increase of anti-inflammatory factors, are a part of the mechanism for captopril-induced survival in thoracic irradiated mice.
The physiology and genetics behind fruiting efficiency: a promising spike trait to improve wheat yield potential
Authors: Pretini Nicole , Alonso María P , Vanzetti Leonardo S , Pontaroli Ana C , González Fernanda G 
Published: February 2021

Abstract
Fruiting efficiency (FE, grains per g of spike dry weight at anthesis) was proposed as a promising spike trait to improve wheat yield potential, based on its functional relationship with grain number determination and the evidence of trait variability in elite germplasm. During the last few years, we have witnessed great advances in the understanding of the physiological and genetic basis of this trait. The present review summarizes the recent heritability estimations and the genetic gains obtained when fruiting efficiency was measured at maturity (FEm, grains per g of chaff) and used as selection criterion. In addition, we propose spike ideotypes for contrasting fruiting efficiencies based on the fertile floret efficiency (FFE, fertile florets per g of spike dry weight at anthesis) and grain set (grains per fertile floret), together with other spike fertility-related traits. We also review novel genes and quantitative trait loci available for using marker-assisted selection for fruiting efficiency and other spike fertility traits. The possible trade-off between FE and grain weight and the genes reported to alter this relation are also considered. Finally, we discuss the benefits and future steps towards the use of fruiting efficiency as a selection criterion in breeding programs.
Resolving a dusty, star-forming SHiZELS galaxy at z = 2.2 with HST, ALMA, and SINFONI on kiloparsec scales
Authors: Cochrane R K , Best P N , Smail I , Ibar E , Cheng C , Swinbank A M , Molina J , Sobral D , Dudzevičiūtė U 
Published: February 2021

ABSTRACT
We present ∼0.15 arcsec spatial resolution imaging of SHiZELS-14, a massive ($M_{*}\sim 10^{11}\, \rm {M_{\odot }}$), dusty, star-forming galaxy at z = 2.24. Our rest-frame ${\sim}1\, \rm {kpc}$-scale, matched-resolution data comprise four different widely used tracers of star formation: the $\rm {H}\,\alpha$ emission line (from SINFONI/VLT), rest-frame UV continuum (from HST F606W imaging), the rest-frame far-infrared (from ALMA), and the radio continuum (from JVLA). Although originally identified by its modest $\rm {H}\,\alpha$ emission line flux, SHiZELS-14 appears to be a vigorously star-forming ($\rm {SFR}\sim 1000\, \rm {M_{\odot }\, yr^{-1}}$) example of a submillimetre galaxy, probably undergoing a merger. SHiZELS-14 displays a compact, dusty central starburst, as well as extended emission in $\rm {H}\,\alpha$ and the rest-frame optical and FIR. The UV emission is spatially offset from the peak of the dust continuum emission, and appears to trace holes in the dust distribution. We find that the dust attenuation varies across the spatial extent of the galaxy, reaching a peak of at least AH α ∼ 5 in the most dusty regions, although the extinction in the central starburst is likely to be much higher. Global star-formation rates inferred using standard calibrations for the different tracers vary from ${\sim}10\!-\!1000\, \rm {M_{\odot }\, yr^{-1}}$, and are particularly discrepant in the galaxy’s dusty centre. This galaxy highlights the biased view of the evolution of star-forming galaxies provided by shorter wavelength data.
Mitonuclear Coevolution, but not Nuclear Compensation, Drives Evolution of OXPHOS Complexes in Bivalves
Authors: Piccinini Giovanni , Iannello Mariangela , Puccio Guglielmo , Plazzi Federico , Havird Justin C , Ghiselli Fabrizio 
Published: February 2021

Abstract
In Metazoa, four out of five complexes involved in oxidative phosphorylation (OXPHOS) are formed by subunits encoded by both the mitochondrial (mtDNA) and nuclear (nuDNA) genomes, leading to the expectation of mitonuclear coevolution. Previous studies have supported coadaptation of mitochondria-encoded (mtOXPHOS) and nuclear-encoded OXPHOS (nuOXPHOS) subunits, often specifically interpreted with regard to the “nuclear compensation hypothesis,” a specific form of mitonuclear coevolution where nuclear genes compensate for deleterious mitochondrial mutations due to less efficient mitochondrial selection. In this study, we analyzed patterns of sequence evolution of 79 OXPHOS subunits in 31 bivalve species, a taxon showing extraordinary mtDNA variability and including species with “doubly uniparental” mtDNA inheritance. Our data showed strong and clear signals of mitonuclear coevolution. NuOXPHOS subunits had concordant topologies with mtOXPHOS subunits, contrary to previous phylogenies based on nuclear genes lacking mt interactions. Evolutionary rates between mt and nuOXPHOS subunits were also highly correlated compared with non-OXPHO-interacting nuclear genes. Nuclear subunits of chimeric OXPHOS complexes (I, III, IV, and V) also had higher dN/dS ratios than Complex II, which is formed exclusively by nuDNA-encoded subunits. However, we did not find evidence of nuclear compensation: mitochondria-encoded subunits showed similar dN/dS ratios compared with nuclear-encoded subunits, contrary to most previously studied bilaterian animals. Moreover, no site-specific signals of compensatory positive selection were detected in nuOXPHOS genes. Our analyses extend the evidence for mitonuclear coevolution to a new taxonomic group, but we propose a reconsideration of the nuclear compensation hypothesis.
Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells
Authors: Bartoschek Michael D , Ugur Enes , Nguyen Tuan-Anh , Rodschinka Geraldine , Wierer Michael , Lang Kathrin , Bultmann Sebastian 
Published: February 2021

Abstract
The genetic code of mammalian cells can be expanded to allow the incorporation of non-canonical amino acids (ncAAs) by suppressing in-frame amber stop codons (UAG) with an orthogonal pyrrolysyl-tRNA synthetase (PylRS)/tRNAPylCUA (PylT) pair. However, the feasibility of this approach is substantially hampered by unpredictable variations in incorporation efficiencies at different stop codon positions within target proteins. Here, we apply a proteomics-based approach to quantify ncAA incorporation rates at hundreds of endogenous amber stop codons in mammalian cells. With these data, we compute iPASS (Identification of Permissive Amber Sites for Suppression; available at www.bultmannlab.eu/tools/iPASS), a linear regression model to predict relative ncAA incorporation efficiencies depending on the surrounding sequence context. To verify iPASS, we develop a dual-fluorescence reporter for high-throughput flow-cytometry analysis that reproducibly yields context-specific ncAA incorporation efficiencies. We show that nucleotides up- and downstream of UAG synergistically influence ncAA incorporation efficiency independent of cell line and ncAA identity. Additionally, we demonstrate iPASS-guided optimization of ncAA incorporation rates by synonymous exchange of codons flanking the amber stop codon. This combination of in silico analysis followed by validation in living mammalian cells substantially simplifies identification as well as adaptation of sites within a target protein to confer high ncAA incorporation rates.
Targeted Truth: An Experiment Testing the Efficacy of Counterindustry Tobacco Advertisements Targeted to Black Individuals and Sexual and Gender Minority Individuals
Authors: Skurka Chris , Wheldon Christopher W , Eng Nicholas 
Published: February 2021

Abstract

Introduction
Some groups disproportionately suffer from tobacco-related illnesses—in part, because the tobacco industry has strategically targeted these groups. To combat industry targeting, antitobacco media campaigns (eg, the truth campaign) have used analogous messaging strategies, describing the industry’s targeted marketing practices to reach these vulnerable groups. We tested the efficacy of counterindustry tobacco advertisements targeted to vulnerable groups (Black individuals and sexual and gender minority [SGM] individuals).

Aims and Methods
From March to July 2020, we recruited N = 1161 young adults in the United States, including n = 430 Black young adults and n = 452 SGM young adults (with n = 108 identifying as Black and SGM). In a web-based, between-subjects experiment, participants were randomized to watch one of four types of advertisement (“ad”): (1) ads from the truth antismoking campaign not targeted toward a specific vulnerable group, (2) Black-targeted truth ads, (3) SGM-targeted truth ads, or (4) unrelated control ads. We examined effects on support for tobacco control policies, counterindustry motivation, counterindustry beliefs, perceived effectiveness, and anger toward the industry.

Results
Relative to control, non-targeted ads increased policy support, and Black-targeted ads increased motivation and beliefs. Targeted ads elicited anger regardless of the audience targeted. However, in general, neither Black identity nor SGM identity moderated the effects of the targeted ads.

Conclusions
We offer little evidence that targeted counterindustry ads are especially influential for their intended group. However, targeted counterindustry appeals may be successful at evoking industry anger regardless of the audience targeted.

Implications
Counterindustry advertisements from the truth campaign targeting Black individuals and SGM individuals had limited effect on tobacco control policies, counterindustry motivation, and counterindustry beliefs. However, counterindustry ads evoked anger toward the industry regardless of ingroup status, which in turn was positively associated with anti-industry outcomes. These results, considered alongside the extant literature, suggest little benefit to developing targeted counterindustry tobacco campaigns for specific groups and instead point to the utility of developing campaigns that appeal to broader audiences.
COVID-19 deaths among nurses: a cross-sectional study
Authors: Keles E , Bektemur G , Baydili K N 
Published: February 2021

Abstract

Background
Nurses who are one of the pivotal elements of countries’ strategic responses to COVID-19 are being exposed to COVID-19.

Aims
To investigate the underlying characteristics of nurses who died due to COVID-19.

Methods
On 1 September 2020, a grey literature search was conducted. Data obtained through Medscape, Google, PubMed, government and non-government websites. The search strategy was carried out using variants and combinations of keywords related to ‘nurse’ and ‘COVID-19’ in English. Abstracted data included age, gender, type of nurse, department of nursing, country, date of death and publication characteristics.

Results
Out of reported 1518 COVID-19-related nurse deaths, details of age, gender and department of nursing were available for 766 (50%), 945 (62%) and 153 (10%) of nurses, respectively. The median age of the nurses was 56 years. The majority of deaths were reported in the 46- to 65 (32%)-year age range. While the registered nurses had the highest number of deaths according to types of nurses (680/957; 71%), they are mental health nurses (42/153; 28%) in the department of nursing. The countries with the most reported nurse deaths were USA, South Africa, Mexico and Russia.

Conclusions
The predominance of deceased mental health nurses among nursing departments can be examined in future studies. Supportive health policies can be developed to increase the motivation of nurses.
T-cell Activation Is Correlated With Monocyte Activation in HCV/HIV Coinfection and Declines During HCV Direct-Acting Antiviral Therapy
Authors: Auma Ann W N , Shive Carey , Damjanovska Sofi , Kowal Corinne , Cohen Daniel E , Bhattacharya Debika , Alston-Smith Beverly , Osborne Melissa , Kalayjian Robert , Balagopal Ashwin , Sulkowski Mark , Wyles David , Anthony Donald D 
Published: February 2021

Abstract

Background
Immune activation markers associate with morbidity and mortality in HIV and hepatitis C virus (HCV) infection. We investigated how T-cell and monocyte activation are related over the course of HCV direct-acting antiviral (DAA) therapy during HCV/HIV coinfection.

Methods
Peripheral blood mononuclear cells from AIDS Clinical Trials Group (ACTG) A5329 participants and a single-site separate cohort treated with DAAs were analyzed for central memory (CM)/effector memory (EM) T-cell subsets, monocyte subsets, and cell activation (CD38 and HLA-DR expression) before, during, and after therapy.

Results
Before therapy, classical and inflammatory monocyte subset HLA-DR expression positively correlated with absolute counts and frequencies of CD38+HLA-DR+-expressing CD4+ and CD8 T cells and corresponding CM and EM subsets. After therapy initiation, CD38+HLA-DR+ co-expression on CD4+ and CD8+ memory T cells decreased by 12 weeks and 36 weeks, and plasma sCD14 positively correlated with CD38+HLA-DR+ CD4+ and CD4+CM T-cell frequencies. Monocyte subset activation remained similar over time.

Conclusions
During HCV/HIV coinfection, memory T-cell activation is associated with monocyte subset activation, consistent with related underlying mechanisms. Following therapy initiation, memory T-cell, but not monocyte, activation decreased. Residual CD4+ T-cell activation after therapy completion is associated with sCD14, potentially linking the remaining CD4+ T-cell activation to residual factors driving activation in antiretroviral therapy–controlled HIV.
Rickets and gross motor delay in a child with atopic dermatitis
Authors: Salloum Shafee , Hatcher Vishaka 
Published: February 2021

ABSTRACT
We report a case of a 14-month-old boy with atopic dermatitis (AD) who presented to our hospital with hypocalcemic tetany and gross motor delay. Further laboratory and imaging confirmed the diagnosis of vitamin D deficiency and rickets. He was breastfeeding and on a restricted diet due to presumed multiple food allergies. He received calcium and vitamin D supplementation which corrected his hypocalcemia. The patient developed Staphylococcus aureus bacteremia and superficial septic thrombophlebitis for which he was treated with antibiotics and anticoagulation. An elimination diet should be avoided in AD patients as true food-induced AD is rare and management should focus on optimal skincare. AD patients have a higher rate of S. aureus skin colonization, which increases their risk for infectious complications. This case also highlights the importance of maintaining a high index of suspicion for rickets in children with isolated gross motor delay, especially in those with risk factors.
Migration and Partisan Change
Authors: Morris Irwin L. 
Published: February 2021

Abstract
As Democratic Party attachment and support for Democratic candidates has begun to grow in the South, existing theories designed to explain Republican growth—whether based on race relations, economic growth, or cultural conservatism—fare poorly. The author advances a new theory—Movers and Stayers theory—to explain this recent growth in Democratic support. This chapter includes a broad outline of the theory—one focused on population growth’s role in the expansion of Democratic support—and an explanation of the dynamics that boost progressivism in high-growth areas and inhibit its development in declining communities. The theory highlights the role of the distinctive progressivism of movers on the political attitudes of stayers in their new homes, and stayers in the communities they have left. The theory explains why community decline results in different political responses from whites and people of color, and it highlights the waning significance of Key’s “black belt” hypothesis.
Population Growth and Partisan Change in the South
Authors: Morris Irwin L. 
Published: February 2021

Abstract
The migratory mechanism at the heart of movers and stayers theory is at the local level, but the aggregation of these localized effects generate state-level dynamics as well. Over the past 20 years, the southern states have increasingly diverged into those with high population growth and those with low population growth. As movers and stayers theory predicts, these differences in population growth produce political differences. There is a substantively and statistically significant relationship between faster population growth and increased support for Democratic presidential candidates. Diverging population trajectories have also eroded the traditional political distinctions between the Rim South and the Deep South. Today, the primary sub-regional distinction is between the high-growth states and the low-growth states. Evidence from the partisan split in U.S. House delegations and both the lower and upper houses of the southern state legislatures clearly illustrates the significance of this new population-based sub-regional distinction.
Populations
Authors: Smil Vaclav 
Published: February 2021

AbstractDemographic transition has been completed everywhere except for large parts of Africa. Steady decline of traditionally high fertilities and mortalities brought temporarily high rates of population growth (globally peaking during the 1960s), as the worldwide count rose from about 1 billion in 1800 to more than 7.8 billion by 2020. The new prevailing pattern of population dynamics is characterized by very low infant mortalities, fertilities well below the replacement level, increasing longevities, and aging, even decline, of many populations. Generations of high growth rates and productivity gains in agriculture and abundance of fossil fuels led to an unprecedented pace of urbanization. More than half of humanity now lives in cities, including a rising number of megacities, each with more than 10 million people.
Introduction
Authors: Daxecker Ursula , Prins Brandon 
Published: February 2021

Abstract
This chapter introduces the reader to the main puzzle and argument motivating the book: piracy affects primarily weak states, but in those states, organized piracy is most common close to coastal areas with some governance and infrastructure. The chapter notes the limitations of existing research on maritime piracy, compares Pirate Lands with research on transnational crime, and argues that the authors’ comparative political economy focus is well-suited to capture the subnational conditions that drive armed robbery on ships and maritime piracy. The chapter sketches the research design and empirical approach. The chapter concludes with the organization of the book.
Maritime Piracy, Past and Present
Authors: Daxecker Ursula , Prins Brandon 
Published: February 2021

Abstract
This chapter offers comparisons of historical and contemporary maritime piracy. It examines the conditions that have driven commerce raiding in the past and the present, which include political violence, privation, geographic opportunity, and governance. The chapter notes that imperial competition, legitimacy gaps, and capacity limits drove privateering and piracy up through the nineteenth century. But while legitimacy gaps and capacity limits continue to incentivize piracy today, weak capacity and lack of legitimacy originate within states rather than states being unable to control and regulate the world’s oceans. Contemporary pirates collude with corruptible local elites rather than with far-off imperial powers. The chapter concludes that historical piracy was often an extension of regime capability, while modern pirates stand in opposition to central state power even as they partner with local governance actors to plunder transiting ships.
Describing Contemporary Maritime Piracy
Authors: Daxecker Ursula , Prins Brandon 
Published: February 2021

Abstract
This chapter begins by describing pirates and their organizations. It provides a sketch of “typical” pirate organizations in countries such as Indonesia, Somalia, and Nigeria. The chapter then proceeds to explore pirate activity. It describes the Maritime Piracy Event and Location Dataset (MPELD) and compares and contrasts these data with other databases on modern sea piracy. Next, the chapter uses the data to illustrate geographic and temporal patterns of maritime piracy. The last section of the chapter provides assessments of key determinants of piracy mentioned in the literature. These empirical patterns provide a basic picture of contemporary maritime piracy.
An Equal Place
Authors: Cummings Scott L. 
Published: February 2021

Abstract
This book is about the role of lawyers in the movement to challenge economic inequality in one of America’s most unequal cities: Los Angeles. Covering a transformative period of city history—from the 1992 riots to the 2008 recession—the book examines how law has been used, and what it has achieved, in the struggle to make Los Angeles a more equal place. The backdrop is the dramatic growth of low-wage work powered by global outsourcing, declining unionism, increasing labor contingency, and surging immigration. The book’s narrative focus is on five pivotal campaigns in which lawyers allied with the city’s dynamic labor, immigrant rights, and environmental movements mobilize law to transform key sectors of the regional economy. These campaigns, analyzed through in-depth case studies, reveal how law has shaped low-wage work in Los Angeles—and at times provided a potent weapon to contest it. Drawing upon archival research, extensive interviews with key actors, and a review of court files, this book explores the role of lawyers in defining the city as a space for redefining work. Challenging critical accounts of lawyers in social movements, its central claim is that by advancing an innovative model of legal mobilization, the L.A. campaigns have achieved meaningful regulatory reform, while strengthening the position of workers in the field of local politics. Through multidimensional advocacy to promote worker organizing, lawyers and activists have succeeded in converting policy change into greater interest group power—forging a new model of progressive city-building for the twenty-first century.