bluuebunny/crossref_metadata_2025_split huggingface dataset:
The outcomes of pregnant and postpartum patients with cerebral venous sinus thrombosis after anticoagulant therapy
Authors: Meng Shi-Hui , Li Jing-Hua , Zuo Li-Jun , Feng Li-Min 
Published: June 2021

Abstract

Background:
To describe the outcome of the patients with cerebral venous sinus thrombosis (CVST) during pregnancy and postpartum treated with anticoagulant therapy.

Methods:
This is a retrospective cohort study and patients with CVST were collected from October 2009 to March 2018. Patients were divided into pregnancy-related (occurred during pregnancy and postpartum) group and non-pregnancy-related. Recovery rate at 12 months after anticoagulant therapy, adverse events, characteristics of patients with poor outcomes were statistically analyzed.

Results:
Fifty-eight pregnancy-related CVST patients (17 pregnancy and 41 postpartum) as study group and 76 non-pregnancy-related CVST women as control group were enrolled. Study group was statistically different to control group in several baseline variables. More pregnancy-related patients had modified rankin scale (mRS) = 5 (15.5% vs 11.8%, P = 8.1×10−3) before anticoagulant therapy. At 12 months heparinization, difference in recovery rate was not statistically significant (80% vs 87.5%, P = .29) between 2 groups. No differences were found of adverse events between 2 groups. Patients with poor outcomes had less sigmoid sinus thrombosis (16.7% vs 61.5%, P = .14), more coma (41.2% vs 17.2%, P = 5.2×10−7), more mRS = 4 (33.3% vs 19.2%, P = 1.63 × 10−4), more mRS = 5 (66.7% vs 9.6%, P = 1.63 × 10−4) before treatment.

Conclusion:
Pregnancy-related CVST patients had severer condition before treatment, but can achieve comparable recovery rate at 12 months after anticoagulant therapy with non-pregnancy-related women. Pregnancy-related patients with poor prognosis had less sinus sigmoid occlusion, more coma, high mRS at admission.
The correlation with tumor radiological characteristics and prognosis of patients with early-stage hepatocellular carcinoma receiving transcatheter arterial chemoembolization
Authors: Lee Shou-Wu , Lee Teng-Yu , Cheng Yu-Chi , Yen Chieh-Ling , Yang Sheng Shun 
Published: June 2021

Abstract
Transcatheter arterial chemoembolization (TACE) is a standard treatment modality for intermediate stage hepatocellular carcinoma (HCC). The aim of this study was to determine the tumor radiological characteristics associated with prognosis of patients with early-staged HCC receiving TACE.
Patients with BCLC stage A HCC were enrolled at Taichung Veterans General Hospital from January 2005 to December 2009. According to mRECIST criteria, patients with or without complete response (CR) were assigned to either the CR group or the non-CR group. Clinical and radiological characteristics were compared between the two groups.
In 40 enrolled patients, 24 (60%) were in the CR group, and 16 (40%) in the non-CR group. Clinical parameters were similar between the 2 groups. Radiological characteristics including complete lipidol retention and the absence of residual tumor blush were significantly correlated with achievement of CR in the patients with small-sized HCC. Patients with CR after TACE had a significantly longer overall survival than those without (31.29 vs 22.63 months, P = .021).
Complete lipidol retention and the absence of residual tumor blush were correlated with the radiological complete tumor response of these patients with small-sized early-stage HCC receiving TACE.
Fabry Disease Frequency Among Young Cryptogenic Stroke Patients in the City of Edirne, Turkey
Authors: Güler Sibel 
Published: June 2021

Background:
We sought to determine the incidence of Fabry disease (FD) in young cryptogenic stroke patients who lived in the City of Edirne, Turkey, and to define the clinical features helping to recognize patients with FD.

Methods:
Acute ischemic stroke patients aged 18 to 55 years who were admitted to our hospital between January 2017 and September 2019 were evaluated for inclusion. The screening was performed for α-galactosidase A activity on dried blood spot, and DNA was sequenced for GLA mutation in patients with low-plasma α-galactosidase A activity.

Results:
Two proband cases were detected. The first proband patient was identified as having a 427G>A (rs 104894845) (p.A143T) hemizygous mutation along with his family; 3 patients were identified as having the same hemizygous mutation; and 6 patients were identified as having the same heterozygous mutations. The second proband patient was identified as having a c.352C>T (rs 148158093) (p.R118C) heterozygote mutation along with her family; 5 patients were identified as having the same heterozygote mutation; and 1 patient was identified as having the same hemizygous mutation. Our study identified the FD incidence as 3.27%.

Conclusions:
This research is just one of a few studies conducted on FD screening studies in Turkish stroke patients. Our results underlined the importance of considering FD during the etiologic evaluation of young cryptogenic stroke patients, as it is a rare but potentially treatable entity.
RNAP II produces capped 18S and 25S ribosomal RNAs resistant to 5’-monophosphate dependent processive 5’→3’ exonuclease in polymerase switched Saccharomyces cerevisiae
Authors: Rocha Miguel A. , Gowda Bhavani S. , Fleischmann Jacob 
Published: June 2021

AbstractWe have previously found in the pathogenic yeast Candida albicans, 18S and 25S ribosomal RNA components, containing more than one phosphate on their 5’-end, resistant to 5’-monophosphate requiring 5’→3” exonuclease. Several lines of evidence pointed to RNAP II as the enzyme producing them. We now show in Saccharomyces cerevisiae, permanently switched to RNAP II, due to deletion part of RNAP I upstream activator alone or in combination with deletion of one component of RNAP I itself, the production of such 18S and 25S rRNAs. They contain multiple phosphates at their 5’-end and an anti-cap specific antibody binds to them indicating capping of these molecules. These molecules are found in RNA isolated from nuclei, therefore are unlikely to be capped in the cytoplasm. This would be unlike recapping of decapped mRNAs which occurs in the cytoplasm. Our data confirm the existence of such molecules and firmly establish RNA II playing a role in their production. The fact that we see these molecules in wild type Saccharomyces cerevisiae indicates that they are not only a result of mutations but are part of the cells physiology. This adds another way RNAP II is involved in ribosome production in addition to their role in the production of ribosome associated proteins.
Emergent Color Categorization in a Neural Network trained for Object Recognition
Authors: de Vries JP , Akbarinia A , Flachot A , Gegenfurtner KR 
Published: June 2021

AbstractColor is a prime example of categorical perception, yet it is unclear why and how color categories emerge. While prelinguistic infants and animals treat color categorically, several recent modeling endeavors have successfully utilized communicative concepts to predict color categories. Rather than modeling categories directly, we investigate the potential emergence of color categories as a result of acquiring visual skills. Specifically, whether color is represented categorically in a convolutional neural network (CNN) trained to recognize objects in natural images. Systematically training new output layers to the CNN for a color classification task, we find clear borders between new (non-training) colors that are largely invariant to the training colors. Using an evolutionary algorithm that relies on the principle of categorical perception we verify these border locations. These results provide strong evidence that color categorization emerges as a function of basic visual skills and provide a new basis for uncovering how they emerge.
Median based absolute quantification of proteins using Fully Unlabelled Generic Internal Standard (FUGIS)
Authors: Raghuraman Bharath Kumar , Bogdanova Aliona , Moon HongKee , Rzagalinski Ignacy , Geertsma Eric R. , Hersemann Lena , Shevchenko Andrej 
Published: June 2021

AbstractBy reporting molar abundances of proteins, absolute quantification determines their stoichiometry in complexes, pathways or networks. Typically, absolute quantification relies either on protein-specific isotopically labelled peptide standards or on a semi-empirical calibration against the average abundance of peptides chosen from arbitrary selected proteins. In contrast, a generic protein standard FUGIS (forFullyUnlabelledGenericInternalStandard) requires no isotopic labelling, chemical synthesis or external calibration and is applicable to quantifying proteins of any organismal origin. The median intensity of peptide peaks produced by the digestion of FUGIS is used as a single point calibrant to determine the molar abundance of any co-digested protein. Powered by FUGIS, median based absolute quantification (MBAQ) outperformed other available methods of untargeted proteome-wide absolute quantification.
Enhanced translation of leaderless mRNAs under oxidative stress in Escherichia coli
Authors: Leiva Lorenzo Eugenio , Orellana Omar , Ibba Michael , Katz Assaf 
Published: June 2021

AbstractThe bacterial response to oxidative stress requires the adaptation of the proteome to the hostile environment. It has been reported that oxidative stress induces a strong and global inhibition of both, transcription and translation. Nevertheless, whereas it is well known that transcription of a small group of genes is induced thanks to transcription factors such as OxyR and SoxR, an equivalent mechanism has not been described for translation. Here we report that whereas canonical translation that depends on Shine Dalgarno recognition is inhibited by oxidative stress in Escherichia coli, the translation of leaderless mRNA (lmRNA) is enhanced under such conditions. Both, inhibition of canonical translation and enhancement of lmRNA translation, depend on the production of (p)ppGpp. We propose that such a mechanism would allow bacteria to rapidly adapt their proteome to hostile conditions and is, perhaps, a general strategy to confront strong stressful conditions.Significance statementThe regulation of translation (the production of proteins based on genetic information) is central for the adaptation to environmental changes. In Escherichia coli translation may begin through two alternative pathways. 1.- A canonical initiation that is well understood and is regulated mostly by changes in the accessibility of ribosomes to specific sequences and 2.- Initiation of leaderless mRNAs (lmRNAs) that lack these sequences and for which we do not understand the regulation process. Our results indicate that under oxidative stress, the production of (p)ppGpp in E. coli inhibits canonical translation and simultaneously enhances translation of lmRNAs, showing for the first time a natural condition where lmRNA translation is regulated and a role for (p)ppGpp in this process.
A TRAF-like E3 ubiquitin ligase TrafE coordinates endolysosomal damage response and cell-autonomous immunity toMycobacterium marinum
Authors: Raykov Lyudmil , Mottet Manon , Nitschke Jahn , Soldati Thierry 
Published: June 2021

ABSTRACTCells are perpetually challenged by pathogens, protein aggregates or chemicals, that induce plasma membrane or endolysosomal compartments damage, recognised as severe stress and controlled downstream by the endosomal sorting complex required for transport (ESCRT) and the autophagy machineries that are recruited to damaged membranes to either repair or to remove membrane remnants. Yet little is known about the upstream endolysosomal damage response (ELDR) factors that sense damage and lead to extensive tagging of the damaged organelles with signals, such as K63-polyubiquitin, required for the recruitment of ELDR components. To explore ELDR key factors responsible for detection and marking of damaged compartments we use the professional phagocyteDictyostelium discoideum. We found an evolutionary conserved E3-ligase, TrafE, that is robustly recruited to intracellular compartments disrupted after infection withMycobacterium marinumor after sterile damage caused by chemical compounds. TrafE acts at the intersection of ESCRT and autophagy pathways and plays a key role in functional recruitment of the ESCRT subunits ALIX, Vps32 and Vps4 to damage sites or maturing autophagosomes. Importantly, we show that the absence of TrafE severely compromises the xenophagy restriction of bacteria as well as ESCRT-mediated and autophagy-mediated ELDR, resulting in early cell death.
Arithmetic properties of singular overpartition pairs without multiples of k
Authors: Nayaka S. Shivaprasada , Sreelakshmi T.K. , Kumar Santosh 
Published: June 2021

PurposeIn this paper, the author defines the function B¯i,jδ,k(n), the number of singular overpartition pairs of n without multiples of k in which no part is divisible by δ and only parts congruent to ± i, ± j modulo δ may be overlined.Design/methodology/approachAndrews introduced to combinatorial objects, which he called singular overpartitions and proved that these singular overpartitions depend on two parameters δ and i can be enumerated by the function C¯δ,i(n), which gives the number of overpartitions of n in which no part divisible by δ and parts ≡ ± i(Mod δ) may be overlined.FindingsUsing classical spirit of q-series techniques, the author obtains congruences modulo 4 for B¯2,48,3(n), B¯2,48,5 and B¯2,412,3.Originality/valueThe results established in this work are extension to those proved in Andrews’ singular overpatition pairs of n.
Farmland lease, high-rent threat and contract instability: evidence from China
Authors: Zhu Wenjue , Paudel Krishna P. , Inoue Sean , Luo Biliang 
Published: June 2021

PurposeThe purpose is to understand why contract instability occurs when small landowners lease their land to large landholders.Design/methodology/approachThe authors develop a contract theoretical model to understand the stability problem in the farmland lease contract in China, where most landowners are small landholders.FindingsResults from the doubly robust estimation method used on randomly selected interview data from 552 households in nine provinces of China indicate that contract instability can arise endogenously when large landholders sign a contract. The authors conclude that a suitable rent control regime or contract enforcement may be necessary to promote a large-scale farmland transfer in China.Originality/valueThe authors develop a contract theoretical model and apply it to the land rental market in China. Data used are original and collected from farmers located in nine provinces of China.
China's Confucius Institute in Africa: a different story?
Authors: Li Siyuan 
Published: June 2021

PurposeChina's Confucius Institutes (CIs) have been under increasing scrutiny in the West while their development in Africa has been steady and strong. This article aims to examine the establishment, operation and effects of this institute in Africa, and discuss its role in a wider context of education, development and China's foreign policy towards Africa.Design/methodology/approachThis empirical research is a case study of China's Confucius Institutes in Africa. Fieldwork data was collected in China and seven CIs in four African countries.FindingsThis research found that the CIs were not just Chinese language and culture promotion organisations in Africa. Rather, they played a deeper and more profound role in training local individuals, involving them in different forms of Chinese presence in Africa and linking their own personal development with the rise of China. In that sense, this article argues that the CI plays a positive role in promoting China's soft power and national interest in Africa. This article also highlights the problems of the institute's operational mode, and casts doubt on some aspects of its future development.Originality/valueThis research systematically examines the establishment, operation and effects of the CIs in Africa, in an attempt to understand the real role of this institute in China's foreign policy towards Africa and demonstrate the uniqueness of the situation of the CIs in Africa.
A decade of the international journal of lean six sigma: bibliometric overview
Authors: Prakash Surya , Kumar Satish , Soni Gunjan , Mahto Raj V. , Pandey Nitesh 
Published: June 2021

Purpose
This study aims to present an overview of leading research trends in the lean six sigma domain published in the International Journal of Lean Six Sigma (IJLSS) since its inception.

Design/methodology/approach
The study analyses articles published between 2010 and 2019 in IJLSS using the bibliometric technique. The results of data analysis identify the most prolific authors, their affiliation, citation trends and highly cited articles from the journal. Further, a graphical analysis involving bibliographic coupling and co-citation analysis of the corpus enriches the investigation.

Findings
The results of the bibliometric analysis suggest that the number of IJLSS’s publications and citations grew markedly over time (from 4 citations in 2010 to nearly 1,324 in 2019). The organizational diversity and collaboration among authors publishing in IJLSS are trending upwards. Case study and focus group are the two most common research designs in publications. In the study, three major themes emerged: implementation of lean on business, integration of lean and six sigma and the effects of lean six sigma on businesses.

Practical implications
The study finding informs and educates practitioners and scholars about various qualitative research tools, applications and methods of implementing lean six sigma tools in different industry sectors.

Originality/value
The study uses bibliometric analysis to propose a novel categorization of research published in IJLSS and to report on the utilization of various lean tools in the journal. The study provides guidance for new future research besides offering a thorough introspection of the lean and six sigma domains.
Exploring the empirical evidence of social desirability bias (SDB) in sport consumer research
Authors: Park Youngho , Kwak Dae Hee 
Published: June 2021

PurposeThe current study aims to provide a systematic approach to detecting and identifying social desirability bias (SDB) in survey data using controversial sponsorship as a research context.Design/methodology/approachWe used an experimental approach to manipulate sponsorship situations (e.g. Beer sponsor vs Sports drink sponsor) that could potentially motivate respondents to under-report their perceptions toward the sponsor. By employing both procedural and statistical approaches, our evidence shows that responses toward the controversial sponsor were in fact contaminated by SDB.FindingsThe findings of the study provide methodological and practical implications for how sport marketing scholars and practitioners can identify, detect and control SDB in self-report data.Originality/valueWe argue that some survey research in sport marketing may be prone to SDB, but SDB has not received sufficient attention in sport marketing research. We emphasize the importance of detecting (and avoiding/controlling) SDB in sport management research.
Ownership structure, board independence and auditor choice: evidence from GCC countries
Authors: Guizani Moncef , Abdalkrim Gaafar 
Published: June 2021

PurposeThis paper investigates the role of board independence in determining the relationship between firm ownership and auditor choice.Design/methodology/approachThe research uses a logistic regression to test the direct and indirect effects of ownership structure on the decision to hire a high-quality (Big 4) audit firm. The sample consists of 207 non-financial firms listed on the Gulf Cooperation Council (GCC) countries stock markets between 2009 and 2016.FindingsEmpirical findings show that family ownership is associated with a negative and significant coefficient suggesting that an increase in family ownership decreases the likelihood that the firm will employ a Big 4 auditor. This finding suggests that family owners are reluctant to impose external monitoring. Furthermore, we find a positive relationship between institutional ownership and auditor choice supporting the conjecture that institutional investors are more likely to choose a Big 4 auditor. The results also reveal that the effects of family and institutional ownership on auditor choice are partially mediated by independent directors.Practical implicationsThis study has important implications for GCC economies whose policymakers and regulators may need to address the conflict between controlling and non-controlling shareholders. It provides guidance for firms in the construction and implementation of their own corporate governance policies. Furthermore, the study findings may be useful to investors, assisting them in making better informed decisions and aids other interested parties in gaining a better understanding of the role played by ownership structure in the quality of auditors. Finally, the paper highlights the importance of the composition of the board of directors in increasing the likelihood of hiring a high-quality audit firm.Originality/valueThe main contribution of the present paper is to examine the board composition as a potential mediating variable between ownership structure and auditor choice. Moreover, it highlights the issue of improving governance mechanisms.
Novel environment friendly olive pomace-cyclohexanone formaldehyde composite resin
Authors: Sert Selda , Kızılcan Nilgün 
Published: June 2021

Purpose
Cyclohexanone-formaldehyde resin (CFR) was in situ modified with olive pomace (OP) in the presence of sodium hydroxide. The purpose of this study is to produce eco-friendly OP modified cyclohexanone composite resins (OPCFCR) with a one-step method that has higher condensation reaction temperature than CFR. The water absorption properties, gloss value and cross-cut adhesion properties of the product were investigated.

Design/methodology/approach
Cyclohexanone, formalin (37% aqueous solution) and tannin were mixed and 20% aqueous NaOH solution was added to produce the resin. OP has environmentally friendly bio-based lignin, cellulose and phenolic compounds and the OP structure has been incorporated into the structure of the CFR resin during the in situ modification, such as resole resin and polysaccharide. The weights of pomace were used as 5% and 10% of the weight of cyclohexanone in cyclohexanone-formaldehyde composite resins, respectively.

Findings
There is an improvement in the properties of the OPCFCR produced from an agricultural waste that is very abundant in Gulf of Edremit region of Balikesir. The OPCFCRs were soluble in common organic solvents. The product OPCFCR has a dark red-brown color.

Research limitations/implications
The reaction mixture must be stirred continuously. Subsequently, 37% formalin was added dropwise in total while refluxing. The amount of aqueous NaOH solution is limited as the formed resin may become insoluble in common organic solvents. At the end of the reaction, a water-insoluble resin is obtained.

Practical implications
This study provides the application of ketonic resins. The OPCFCR containing phenolic groups may also promote the adhesive strength of a coating.

Social implications
These resins may be used for the preparation of adhesive. OP, with a large amount of catechol groups, was considered for reducing the formaldehyde emission level on the adhesive system.

Originality/value
OPCFCR has been synthesized in the presence of a base catalyst. Environmental and ecological concerns have increased the attention paid by chemical industry to renewable raw materials.