bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Capacity for Public Health Education in India: Recommendations from a Mixed Methods Landscape Analysis
Authors: Schleiff Meike , Brahmbhatt Haley , Banerjee Preetika , Reddy Megha , Miller Emily , Majumdar Piyusha , Mangal D K , Gupta Shiv Dutt , Zodpey Sanjay , Shet Anita 
Published: April 2021

Abstract
Background: Public health training has been expanding in India in recent years. The COVID-19 pandemic has brought additional attention to the importance of public health programs and the need for a strong workforce. This paper aims to assess the current capacity for public health education and training in India and provide recommendations for improved approaches to meet current and future public health needs. Methods: We conducted a desk review of public health training programs via extensive internet searches, literature reviews and expert faculty consultations. Among those programs, we purposively selected faculty members to participate in in-depth interviews. We developed summary statistics based on the desk review. For qualitative analysis, we utilized a combination of deductive and inductive coding to identify key themes and systematically reviewed strengths and weaknesses for each theme. Results: The desk review captured 59 institutions offering public health training across India. The majority of training programs were graduate level degrees including master of public health (MPH) and master of science (MS) degrees. Key themes included collaborations, mentorship, curriculum standardization, tuition and funding, and student demand for public health education and careers. Collaborations and mentorship were highly valued but varied in quality across institutions. Curricula lacked standardization but also contained substantial flexibility and innovation as a result. Public sector programs were affordable and student stipend varied across institutions. Further development of the demand-side with greater opportunities for career for careers in public health is needed. Conclusion: Public health education and training in India has a strong foothold. There are numerous opportunities for continued expansion and strengthening of this field, to support a robust multi-disciplinary public health workforce that will contribute towards achieving the sustainable development goals.
Online SARIMA applied for short-term electricity load forecasting
Authors: Nguyen Quang Dat , Nguyen Nhat Anh , Tran Ngoc Thang , Solanki Vijender Kumar , Crespo Rubén González , Nguyen Thi Ngoc Anh 
Published: April 2021

Abstract
Short-term Load Forecasting (STLF) plays a crucial role in balancing supply and demand of load dispatching operation, ensures stability for the power system. With the advancement of real-time smart sensors in power systems, it is of great significance to develop techniques to handle data streams on-the-fly to improve operational efficiency. In this paper, we propose an online variant of Seasonal Autoregressive Integrated Moving Average (SARIMA) to forecast electricity load sequentially. The proposed model is utilized to forecast hourly electricity load of northern Vietnam and achieves a mean absolute percentage error (MAPE) of 4.57%.
On a Greedy Approach for Genome Scaffolding
Authors: Davot Tom , Chateau Annie , Fossé Rohan , Giroudeau Rodolphe , Weller Mathias 
Published: April 2021

Abstract
Background: Scaffolding is a bioinformatics problem aimed at completing the contig assembly process by determining the relative position and orientation of these contigs. It can be seen as a paths and cycles cover problem of a particular graph called the “scaffold graph”.Results: We provide some NP-hardness and inapproximability results on this problem. We also adapt a greedy approximation algorithm on complete graphs so that it works on a special class aiming to be close to real instances. The described algorithm is the first polynomial-time approximation algorithm designed for this problem on non-complete graphs.Conclusion: Tests on a set of simulated instances show that our algorithm provides better results than the version on complete graphs.
Benzoate, Gallate, And Salicylate Regulate Redox-Enzymes, Ultrastructure, And Accumulation of Boron To Counteract Boron Toxicity On Tomato Callus Cells
Authors: Radi Abeer A , Salam Hussein Kh , Hamada Afaf , Farghaly Fatma A 
Published: April 2021

Abstract
The participation of benzoate (BA), gallate (GA), and salicylate (SA) in various biochemical and physiological processes in plants under conditions of excessive boron (EB) is largely unknown to date. Here, the relationships between phenolic acids (PAs) and the regulation of redox-enzymes, the ultrastructure of cells, and boron forms in the mitigation of EB-induced oxidative stress within tomato calli were studied. Tomato calli were exposed to 2 mM boron (B) in the presence or absence of three concentrations of benzoate, gallate, and salicylate. The data showed that different concentrations of PA counteracted the inhibition of growth and oxidative stress of EB stress by reducing hydrogen peroxide (H2O2) production, lipoxygenase (LOX) activity, boron accumulation forms, cell wall thickening, and moderate concentrations were the most effective. Applications of PAs reduced the catalytic impacts of EB on superoxide dismutase (SOD) and catalase (CAT) activity. Likewise, benzoate and gallate increased the influences of EB stimulation on peroxidase (POD) and ascorbate peroxidase (APX) activities; whereas, SA reduced these effects on both enzymes. PA treatments enhanced the insignificant catalytic effect of EB on the activity of phenylalanine ammonia-lyase (PAL), as well as the stimulation of the negative influence of EB on polyphenol oxidase (PPO) activity. The findings highlight that PAs play an important role in alleviating EB stress in tomato plants by regulating redox enzymes, B-accumulation forms, and cell wall thickening. This study provides new perspectives for strategies related to excess boron tolerance in tomato plants and thus can be used as plant growth promoters.
Weighted Gene Co-Expression Network Analysis and Machine learning Identify Critical Genes in the Development of Osteomyelitis after Staphylococcus aureus Infections
Authors: Chen Baixing , Li Shaoshuo , Lu Zhaoqi , Huang Mingling , Lin Shi , Dong Hang 
Published: April 2021

Abstract
Background: Staphylococcus aureus (S. aureus) is the most common pathogen that causes osteomyelitis (OM). However, OM's pathogenesis, which is not clear, involves many factors such as environment, genetics and immunity dysregulation. This study aims to explore the key genes involved in the pathogenesis and development of OM following S. aureus infection. Methods: After obtaining the datasets of GSE6269 and GSE16129, we performed weighted gene co-expression network analysis (WGCNA) to find clusters modules of highly correlated genes and recursive feature elimination (RFE) method to narrow the range of feature genes. For determining the effect of feature genes, we constructed a random forest (RF) model with feature genes and validated the predictive validity of the RF model using independent data from GSE11908. The protein-protein interaction (PPI) network identifies essential proteins that contributed to OM development. Results: There were 12,401 genes from 77 samples that 48 S. aureus patients developed to OM and 29 of those without OM. We divided 31 significant gene modules into different modules, and the brown module signiﬁcantly related to OM. Biological Functions of the brown module mainly enriched in the inflammatory response, metabolic, cancer, viral pathways, protein binding and RNA binding. After screening, 19 genes, including CYP2E1, BBS10, ARPC5L, GAPVD1, PURA, RBMS1, BTN2A2, EXOSC8, METTL8, FYCO1, KHK, PRPF38B, CD72, C2CD5, ABHD6, CD200, FAM53C, HCP5 and ELP1, were defined as feature genes for constructing RF model. After validating the external data, the average area under the curve was 85%, and the accuracy of the RF model was 85.7%. The protein function of modules enriched in the RNA exosome complex's catalytic component and regulation of actin polymerization. Conclusions: This study aimed to identify related genes involved in the occurrence and development of OM. We constructed the RF model with 19 genes, which effectively classify the patients with OM or non-OM. Despite its limitations, the study certainly adds to our understanding of OM's pathogenesis, and therefore, has significant implications for potential therapeutic targets and the predicted value of OM.
Influence Of Geographical Area And Living Setting On Weight Status, Gross Motor Coordination And Physical Activity Level Of Italian School Children: The Neighbourhood Walkability Approach
Authors: Gallotta Maria Chiara , Zimatore Giovanna , Falcioni Lavinia , Migliaccio Silvia , Lanza Massimo , Schena Federico , Biino Valentina , Giuriato Matteo , Bellafiore Marianna , Palma Antonio , Battaglia Giuseppe , Guidetti Laura , Baldari Carlo 
Published: April 2021

Abstract
Background: The prevalence of overweight and obesity in childhood is increasing at an alarming rate worldwide, particularly in industrialized countries. Walkability measurements can be collected using the free open software Walk Score® that permit the measure of estimating neighbourhood walkability in many geographic locations. This study was aimed i) to investigate whether differences between rural and urban settings in the North, Centre and South of Italy could influence body-weight status, motor competence and physical activity (PA) level in school-age children; ii) to analyse the walkability of different school areas, and iii) to examine the relationship of motor competence, PA level, geographical areas, living setting, and neighbourhood walkability with children’s body-weight status. Methods: We assessed anthropometric parameters, gross motor coordination and PA level in 1549 children aged between 8 and 13 year. Three geographical areas (North, Centre, South of Italy), two settings (urban and rural) and neighbourhoods’ walkability (Walk Score®) were considered in the analysis. Results: The prevalence of overweight and obesity was 22.0% and 9.9%, respectively; 47.9% of the total sample showed motor impairments and 29.0% was inactive. Central children had higher BMI than Northern and Southern children. Northern children showed the highest MQ and PA level, followed by Southern and Central children. Children from the South of Italy attended schools located in neighbourhoods with the highest Walk Score®. Urban children attended schools located in neighbourhoods with a higher Walk Score® than rural children. Lower MQ, lower PA level, living in rural setting and in a car-dependent neighbourhood were associated with a higher relative risk for obesity. Being a girl was associated with a lower relative risk for obesity.Conclusions: The alarming high percentage of overweight and obesity in children as well as motor coordination impairments revealed the urgent need of targeted PA interventions in paediatric population.
Treatment patterns and Outcomes of Elderly Patients with Potentially Curable Esophageal Cancer
Authors: Yang Yang , Chen Mengyuan , Xie Jiping , Ji Yongling , Sheng Liming , Qiu Guoqin , Du Xianghui , Wei Qichun 
Published: April 2021

Abstract
Background: The proportion of elderly patients with esophageal cancer (EC) is increasing due to prolonged life expectancy and aging process. However, the optimal treatment strategy for elderly patients (aged ≥70 years) with EC remains controversial.Methods: Eligible patients with cT1b-4aNxM0 EC were identified in the Surveillance, Epidemiology, and End Results database from 2010 to 2016. Treatment patterns were divided into five groups: surgical resection (S), chemoradiotherapy (CRT), radiotherapy (RT), chemotherapy (CT), or observation with no treatment (Obs). Survival between groups was compared using the log-rank test, and the Cox proportional hazards model was used to identify factors associated with overall survival (OS).Results: A total of 3233 patients with potentially curable EC were identified. Of all the patients included, 29.1%, 48.2%, 8.7%, and 3.5% received S, CRT, RT, and CT, respectively, whereas 10.5% underwent Obs. The 3-year OS estimates were 45.8% (95% confidence interval [CI]: 42.2–49.8%), 26.1% (95% CI: 23.5–28.9%), 12.2% (95% CI: 8.4–17.8%), 14.9% (95% CI: 8.4–26.4%), and 6.7% (95% CI: 4.0–11.0%) for S, CRT, RT, CT, and Obs (p<0.001), respectively. However, the survival benefits of surgery over CRT gradually weakened with the increase in age, and the survival benefit of surgery was statistically non-significant for EC patients aged ≥80 years (p=0.41). Multivariate analysis showed that treatment patterns, age, tumor grade, T stage, N stage, and marital status were significantly associated with OS.Conclusion: Generally, the use of surgery was associated with the longest OS, and CRT was superior to RT or CT alone in elderly patients with curable EC. For patients intolerable to surgery or aged ≥80 years, definitive CRT should be considered as a preferable option. The optimal treatment strategy for elderly patients with EC should consider comprehensive geriatric assessment, survival benefit, and patient preference in a multidisciplinary setting.
Variations of Phyllosphere and Rhizosphere Microbial Communities of Pinus Koraiensis Infected by Bursaphelenchus Xylophilus
Authors: Deng Jiaojiao , Yu Dapao , Zhou Wangming , Zhu Wenxu , Zhou Li 
Published: April 2021

Abstract
Pinewood nematode, Bursaphelenchus xylophilus, as one of the greatest threats to pine trees, is spreading all over the world. During the nematode’s pathogenesis, plant microorganisms play important roles.The phyllosphere and rhizosphere bacterial and fungal communities associated with healthy P. koraiensis (PKa) and P. koraiensis infected by B. xylophilus at the early (PKb) and last (PKc) stages were analyzed. Pine wood nematode (PWD) could increase the phyllosphere and rhizosphere microbial community diversity, and slight shifts of the microbial diversity were observed at the early stage of infection. Generally speaking, an increase in microbial diversity with more serious symptomatic phase was obvious and visible. The phyllosphere and rhizosphere microbial community potentially changed caused by B. xylophilus infection of P. koraiensis. With the infection of B. xylophilus in P. koraiensis, Bradyrhizobium (rhizosphere bacteria), Massilia (phyllosphere bacteria), Phaeosphaeriaceae (rhizosphere fungi) were the major contributors to the differences in community compositions among different treatments. With the infection of PWD, most of the bacterial groups tended to be co-excluding rather than co-occurring. These changes would correlate with microbial ability to suppress plant pathogen, enhancing the understanding of disease development and providing guidelines to pave the way for its possible management.
Vitamin D Role in Chronic Dacryocystitis
Authors: Valentín-Bravo Francisco Javier , Onrubia Luis García , Pacheco-Callirgos Gabriela Estefanía , Asensio-Sánchez Victor Manuel 
Published: April 2021

Abstract
Introduction: Vitamin D deficiency has been associated with dry eye disease or Sjogren's syndrome. Due to the anti-inflammatory role of vitamin D in eye diseases, it has been proposed to study the role of this vitamin in chronic dacryocystitis, which is an infectious and inflammatory process affecting the nasolacrimal system. Objective: Determine the association between vitamin D levels with the presence of chronic dacryocystititis.Materials and Methods: A cross-sectional descriptive observational study analyzed a sample of 40 individuals, of whom had been diagnosed with chronic dacryocystitis. Biochemical tests for serum 25-hydroxyvitamin D (vitamin D) were subjected to the entire sample. The difference in the means was calculated using the T-test for associated data. The reference significance value was 0.05.Results: Chronic dacryocystitis commonly occurs in the age group of 51 to 67 years. Women were more vulnerable to infection than men. No association was found between the presence of chronic dacriocystitis and vitamin D levels (p-0.755). It is recommended to use larger cohorts as well as multicenter studies evaluating this association, such as supplemental use of vitamin D on a large scale.Conclusions: Low vitamin D levels are not associated with the presence of chronic dacriocystitis.
In vitro and in vivo evaluation of cytotoxic effect of targeted agents alone or in combination with chemotherapy for the treatment of adenoid cystic carcinoma
Authors: Savarese Teresa , Abate Andrea , Basnet Ram Manohar , Lorini Luigi , Gurizzan Cristina , Tomasoni Michele , Lombardi Davide , Tomasini Davide , Zizioli Daniela , Memo Maurizio , Berruti Alfredo , Bonini Sara Anna , Sigala Sandra , Bossi Paolo 
Published: April 2021

Abstract
Purpose

Adenoid cystic carcinoma (ACC) is a rare malignancy characterized by high incidence of relapse. When relapsing, ACC has an indolent but relentless behaviour, thus leading to a poor long-term prognosis. The treatment of choice of relapsing ACC remains surgery followed by radiotherapy, whenever feasible. Therapeutic weapons are limited to systemic drugs. The most widely used chemotherapy regimen is the combination of cisplatin and doxorubicin, however with low response rate and not long lasting; there is also a lack of alternatives for second line therapies in case of disease progression. Therefore, a more comprehensive strategy aimed at identifying at preclinical level the most promising drugs or combination is clearly needed.
Methods

In this study, the cytotoxic effects of two standard chemotherapy drugs, cisplatin and doxorubicin, and of five targeted therapy-drugs was tested in vitro, on an h-TERT immortalized ACC cell line. The same drugs were also tested in vivo, on zebrafish embryos with ACC tumoral cell xenograft. Then, combinations of one standard chemotherapy drug plus one targeted therapy drug were also evaluated, in order to find the best treatment strategy for ACC.
Results

Data obtained demonstrated that both vorinostat and olaparib significantly increased the standard chemotherapy cytotoxic effects, suggesting new interesting therapeutic options for ACC.
Conclusion

Data obtained in the present study provide valid new therapeutic strategies for ACC to be translated in a prospective clinical trial.
Allograft Fibula Combined with Cannulated Screw for Femoral Head Necrosis: A Finite Element Analysis
Authors: Zhao Gan , Liu Ming , Li Bin , Lin Tianye , Xu JingLi , Sun Haizhong , Biaofang Wei 
Published: April 2021

Abstract
Background: Osteonecrosis of femoral head (ONFH) is characterized by high incidence and disability. Allograft fibula combined with cannulated screw has been extensively applied for treating Osteonecrosis of femoral head. However, its biomechanical outcomes remain unclear. The present study aimed to investigate the optimal placement of the allograft fibula and cannulated screw for treating ONFH.Methods: Two types (C1 and C2) of NONFH finite element models were built based on a healthy subject and the Japanese Investigation Committee (JIC) classification system. The allograft fibula combined with cannulated screw was simulated in the respective type of the model. Different models were built by complying with the different positions of allograft fibula and cannulated screw (below model, posteriorly below model, anteriorly below model and anteriorly above model). Furthermore, a comparison was drawn on the maximum stress value and the mean stress value of the subchondral cortical bone of femoral head weight-bearing area.Results: As indicated from the finite element analysis, normal femoral head, necrotic femoral head and postoperative femoral head achieved the different maximum stress values, and the maximum stress value achieved by necrotic femoral head significantly reached over that of normal femoral head. After the operation, the maximum stress value of subchondral cortical bone in the weight-bearing area of the femoral head was noticeably down-regulated compared with that before the operation (necrotic femoral head). When the cannulated screw was directly below the fibula, subchondral cortical bone in the weight bearing area of femoral head achieved the smallest maximum stress value and average stress value, which showed a statistical difference from those of other models (P<0.05).Conclusion: Allograft fibula combined with cannulated screw is capable of significantly reducing the stress of subchondral cortical bone in the weight-bearing area of the ONFH femoral head, as well as down-regulating the stress concentration in the ONFH weight-bearing area. For JIC C1 and C2 osteonecrosis of the femoral head, when administrated with allograft fibula combined with cannulated screw, the optimal biomechanics was the cannulated screw located just directly below the fibula.
Broadband Radar Invisibility with Time-Dependent Metasurfaces
Authors: Kozlov Vitali , Vovchuk Dmytro , Ginzburg Pavel 
Published: April 2021

Abstract
Concealing objects from interrogation has been a primary objective since the integration of radars into surveillance systems. Metamaterial-based invisibility cloaking, which was considered a promising solution, did not yet succeed in delivering reliable performance against real radar systems, mainly due to its narrow operational bandwidth. Here we propose an approach, which addresses the issue from a signal-processing standpoint and, as a result, is capable of coping with the vast majority of unclassified radar systems by exploiting vulnerabilities in their design. In particular, we demonstrate complete concealment of a 0.25 square meter moving metal plate from an investigating radar system, operating in a broad frequency range approaching 20% bandwidth around the carrier of 1.5GHz. The key element of the radar countermeasure is a temporally modulated coating. This auxiliary structure is designed to dynamically and controllably adjust the reflected phase of the impinging radar signal, which acquires a user-defined Doppler shift. A special case of interest is imposing a frequency shift that compensates for the real Doppler signatures originating from the motion of the target. In this case the radar will consider the target static, even though it is moving. As a result, the reflected echo will be discarded by the clutter removal filter, which is an inherent part of any modern radar system that is designed to operate in real conditions. This signal-processing loophole allows rendering the target invisible to the radar even though it scatters electromagnetic radiation.
New Insights Into the Promising Antibacterial Activity of Thiophene or Chromene Moiety Containing Aryl Sulfonamide
Authors: Kumar Ajay , Prakash Om , Vivekanand  , Saxena M.K. , Kasana Virendra , Rathore Sanjeev , Singh Satyendra 
Published: April 2021

Abstract
Background: Aryl sulfonamides bearing thiophene and chromene moieties have been reviewed for their antibacterial activity and their synthetic methods. Heterocyclic moiety containing aryl sulfonamide compounds are dispersed in nature and are crucial for life. Diverse investigational strategies towards a structural relationship that cognizance upon the exploration of optimized candidates have grown to be extremely crucial.Method: Literature research tells that for a series of thiophene or chromene moiety containing aryl sulfonamide compoundsare vital in medicinal and industrial chemistry.Aryl sulfonamidescontainingheterocyclic moieties display pharmacological activities against pathogenic microbes.Result:Recent various disciplinary reported articles had been cited in this review article to define the potentialantibacterial properties of thiophene-arylsulfonamide and chromene-arylsulfonamide. Conclusion: The finding of this review confirms the importance of aryl sulfonamidescontaining thiophene or chromene moiety as potential antibacterial agents. These final resultswill give ideasto the synthesis and developmentof reactions leading to the potential derivativesfor betterpharmacological applications.