bluuebunny/crossref_metadata_2025_split huggingface dataset:
The early book herbaria of Leonhard Rauwolf (S. France and N. Italy, 1560–1563): new light on a plant collection from the ‘golden age of botany’
Authors: Stefanaki Anastasia , Walter Tilmann , Porck Henk , Bertin Alice , Andel Tinde van 
Published: March 2021

Abstract
The 16th century was a golden age for botany, a time when numerous naturalists devoted themselves to the study and documentation of plant diversity. A prominent figure among them was the German physician, botanist, and traveler Leonhard Rauwolf (1535?–1596), famous for his luxurious book herbarium containing plants from the Near East. Here we focus on the less studied, early book herbaria of Rauwolf. These form a three-volume plant collection bound in leather and gold, which contains over 600 plants that Rauwolf collected between 1560 and 1563 in S. France and N. Italy when he was a student of medicine. We show the botanical value of Rauwolf’s early book herbaria, exemplified by two exotic American specimens, namely one of the oldest surviving specimens of tobacco (Nicotiana rustica), collected in Italy, and the oldest known French record of prickly pear (Opuntia ficus-indica). We discuss Rauwolf’s professional botanical network during his student years and suggest that the famous Swiss botanist Johann Bauhin (1541–1613), friend and companion of Rauwolf during his field excursions and their medical studies in Montpellier, has played a significant role in the compilation of this precious historical plant collection. We also reconstruct the story of the compilation of the book herbaria, as evidenced through observations of paper watermarks and written texts in the book volumes and show that all four book herbaria of Rauwolf were probably bound between 1577 and 1582.
WHO Grade III Anaplastic Astrocytoma In A 72 Years Old Male-A Case Report
Authors: Jaiswal Vikash , Ruxmohan Samir , Gupta Sneha , Hange Namratah , Mukherjee Dattatreya 
Published: March 2021

Abstract
Glioma is a common type of tumor that originates in the glial cell in brain and is devastating in nature. It can affect all age groups but is more common in adults and has been found more in males than in females with a ratio of 1.3/1. Despite the aggressive treatment it relapsed and can cause mortality because of its infiltrative nature. This WHO type III Anaplastic Astrocytoma is more common in 40-50 years old with a median of 41 years. Here, we report a new case of Glioma occurring in a 72 year old male, who presented with a right sided headache, forgetful, worsening memory, behavioral problem along with increased agitation and irritability. MRI Brain WO/W revealed a mass in the left thalamus and basal ganglia region with a thick rim of peripheral enhancement. Diagnosis of Anaplastic Astrocytoma (WHO Grade III) was confirmed by histology and immunohistochemical analysis of the tumor.Conclusion:It is a case of Left sided WHO GRADE III Anaplastic astrocytoma which is rare in this age group of 72 years. The patient was managed with gamma knife radiosurgery, chemotherapy with Temozolomide (TMZ), and targeted molecular therapy with Bevacizumab. The patient improved with remission of symptoms.
Clinical significance of detecting organ-specificsensitization in patients with long-term chronic posttraumatic uveitis
Authors: Balatskaya N. V. , Filatova I. A. , Zakharova G. P. , Kulikova I. G. , Denisyuk V. O. , Mohammad I. M. 
Published: March 2021

Purpose: to assess the clinical significance of detecting organ-specific sensitization in chronic posttraumatic uveitis (CPTU) based on a comparative analysis of data from the leukocyte migration inhibition test (LMIT) and histological examination.Materials and methods. We examined 54 patients aged 17-82 with CPTU who underwent surgical removal of the eyeball (by enucleation/evisceration). To detect organ-specific sensitization, the LMIT in whole blood with extracts of corneal, lens, and uvearetinal tissue antigens was used. The eyes were subjected to histological examination after removal.Results. A positive response in LMIT was detected in 35.2 % of patients with CPTU. Pathomorphological signs of immune inflammation were found in 55.5 % of cases (30 eyes). In 23 eyes (42.6 %), the morphological picture was characterized by atrophic, fibrous and dystrophic changes in tissues. Based on the data from a comparative analysis of LMIT results and histological studies, we showed that in 16 cases out of 30 (53.3 %), morphologically confirmed immune inflammation was accompanied by sensitization to antigens of eye shells.Conclusions. In half of the cases, a productive inflammation, detected in CPTU during histological examination, was associated with the development of specific sensitization to eye tissue antigens. This result is important and should be considered when choosing how the patient should be managed, including targeted diagnostics and immunotropic therapy. The negative organ-specific response of LMIT in patients with chronic CPTU and intraocular inflammation confirmed by pathomorphological signs suggests a possible involvement of additional mechanisms of the inflammatory process, which requires further research.
Survival of retinoblastoma patients: a cohort study by two Russian medical centers
Authors: Saakyan S. V. , Ivanova O. A. , Tadevosyan S. S. , Tsygankov A. Yu. , Olkhova L. V. , Ushakova T. L. , Polyakov V. G. 
Published: March 2021

Purpose. To evaluate the overall, disease-specific, event-free, relapse-free survival of retinoblastoma (RB) patients and cumulative probability of eye survival in such patients.Material and methods. The study included 223 children with RB (126 male, 97 female). Monolateral disease was diagnosed in 69.1 % of cases (n = 154), bilateral disease in 30.9 % (n = 69). The median follow-up was 40 months (interquartile range from 27 to 53 months). According to ABC classification, group A was diagnosed in 16 of 292 eyes (5.5 %), group B — in 53 (18.2 %), group C — in 41 (14.0 %), group D — 58 (19.9 %), and group E — in 124 (42.5 %). Group E was detected twice as often in patients with unilateral RB as in bilateral RB (56.5 % versus 26.8 %; p < 0.01). Stage T1 according to TNM classification was diagnosed in 69 cases (23.6 %), stage T2-T3 — in 213 cases (72.9 %). The extraocular form (stage T4) was detected in 3.4 % of cases (n = 10).Results. The overall five-year survival of patients treated for RB (n = 223) was 96.4 ± 1.4 %. The 5-year disease- specific survival (n = 222) was 96.8 ± 1.3 % in the general cohort, 96.5 ± 1.5 % in the group of children with monocular RB, 97.3 ± 2.7 % for binocular RB. Five-year event-free survival rate of children who received treatment (n = 223) was 66.7 ± 3.6 %, with monolateral lesion (n = 154) — 74.1 ± 4.2 %, with bilateral lesion — 50.6 ± 6.2 % (n = 69). Five-year relapse-free survival took place in 83.3 ± 3.1 %, with monolateral RB — 87.8 ± 3.3 %, with bilateral RB — 73.3 ± 6.4 %. Primary enucleation was performed in 121 of the 223 children treated for RB and included in the study. The frequency of primary enucleation with monocular RB was more than twice as high (55.2 %; 85 of 154 eyes) as with binocular RB (26.1 %; 36 of 138 eyes; p < 0.01). Organ-preserving treatment was carried out in 138 cases (171 eyes). It was effective in 123 (89.2 %) children (152 eyes; 88.9 %). 5-year ocular survival was 85.7 ± 3.7 %, with monolateral RB — 78.2 ± 6.6 %, with bilateral RB — 92.2 ± 2.8 %. Ocular survival counted separately for groups A, B, C, D, equaled 100 %, 100%, 76.6 ± 6.9 %, and 71.1 ± 11.9 %, respectively. The five-year disease-specific survival rate of children with monocular lesion given eye-preserving treatment was 100%, significantly higher than after primary enucleation — 93.4 ± 2.9 %.Conclusions. Modern combined retinoblastoma treatment is able to save the sick children’s lifes and and even their eyes and visual functions, which improves social adaptation and quality of life. It has been shown that, with a binocular form, it is possible to save more eyes than with a monocular form. Eye-preserving treatment administered to patients with intraocular RB under strictly observed criteria does not heighten the risk of metastasis. Yet timely enucleation in cases of absolute indications remains the method of choice in saving the life of a child.
Investigating the Mechanism of Action of Frankincense against Drug- Induced Liver Injury Using Network Pharmacology and Molecular Docking
Authors: Liao Yu-cheng , Wang Jing-wen , Yang Qian , Wang Wen-jun , Zhao Chao , Sun Lian , Wen Ai-dong , Li Rui-li , Ding Yi 
Published: March 2021

Background:
Frankincense has been used as a traditional medicine in many countries.
It is an important herb with multiple targets and therapeutic effects, including liver protection.
However, its mechanism of action in drug-induced liver injury (DILI) remains unknown.

Objective:
The purpose of this work was to elucidate the active components, core genes, and
molecular mechanism of frankincense in DILI through network pharmacology and molecular
docking approaches.

Methods:
The active components of frankincense and its target genes were obtained from the
BATMAN-TCM database, and the DILI target genes were obtained from the GeneCards and Drug-
Bank databases. Cytoscape was used to create the compound-shared gene target network. STRING
and DAVID software were used to analyze key targets and pathway enrichment. Autodock Vina
software was used for molecular docking.

Results:
Network analysis identified 16 compounds in frankincense and 103 target genes highly
related to DILI. The core genes in the protein-protein interaction network are INS, IL6, TP53, TNF,
SRC, PTGS2, IL1B, CAT, IL10, and IGF1. Furthermore, GO and KEGG pathway enrichment analyses
indicated that the effect of frankincense on DILI is related to positive regulation of transcription
from RNA polymerase II promoter and inflammatory response. Core pathways such as the HIF-1,
TNF, FoxO, PI3K-Akt, and the sphingolipid signaling pathway are closely related to DILI.

Conclusion:
This study revealed the chemical constituents and pharmacological effects of frankincense
and unveiled potential DILI healing targets. This study could provide insights for further
development of drugs that specifically target DILI.
Epinucleus Scraping: Safe New Phacoemulsification Technique for Rock-Hard Cataracts
Authors: Kondo Aki , Goto Mari , Mimura Tatsuya , Tanaka Shunichi , Matsubara Masao 
Published: March 2021

Introduction:
Phacoemulsification of rock-hard cataracts is challenging because the leathery epinucleus at the posterior plate often found in such cataracts tends to prevent smooth dissection of the nucleus. We devised an Epinucleus scraping technique to overcome this problem.

Methods:
The epinucleus is initially stripped of the hard endonucleus using a new instrument. The isolated endonucleus can then be readily chopped and divided with a phaco chopper or in the usual manner.

Conclusion:
Phacoemulsification of rock-hard cataracts can be carried out safely and easily with epinucleus scraping technique.
Study of Coronavirus Disease (COVID-19) Outbreak in India
Authors: Deshwal Vaishali , Kumar Vimal 
Published: March 2021

Background:
COVID-19 is an infectious disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). It has been recognized as a pandemic by the World Health Organization (WHO) on 11th March, 2020.

Objective:
To identify various factors that can increase coronavirus spread in India and predict COVID-19 cases up to 27th December, 2020, minimum and maximum number of deaths due to COVID-19 in India.

Methods:
This work predicts COVID-19 cases, the minimum and the maximum number of deaths due to COVID-19 in India based on the infection rate and suspected cases.

Results:
Our result shows that the number of COVID-19 cases will increase exponentially in India to approximately 859421415 cases by 27th December 2020.

Conclusion:
The spread of COVID-19 in India depends on a lot of factors such as religious congregation, social contact structure, low testing rates, identification of COVID-19 suspects, measures such as lockdown and sealing of hot stop, etc. taken by the Indian government. In India, lockdown proved to be a good decision.
Larval Morphology and Molecular Identification of Ophthalmomyiasis Flies and its Incidence Rate in Referred Patients to an Ophthalmology Clinic, Shiraz, Iran
Authors: Keshavarz Ali , Alipour Hamzeh , Azizi Kourosh , Khalili Mohammad Reza , Namadi Marziea Shahriari , Bagheri Masoumeh , Raz Abbasali 
Published: March 2021

Background:
Myiasis is the infestation of flies' larvae in living or dead tissues of the human body and animals. Ophthalmomyiasis is divided into internal and external types and thelarvae penetrate eyes in the internal type. This study aimed to examine larval morphology and molecular identification of flies causing ophthalmomyiasis and determine its incidence rate in referred patients to an ophthalmology clinic in Shiraz during 2019.

Materials and Methods:
During one year, all larvae were isolated from patients’ eyes. These larvae were identified using the morphological method according to the 1965 diagnostic key of Zumpt. Molecular confirmation was performed using a pair of specific primers for the Cytochrome Oxidase I (COI) gene in the next step. The expected amplicons were sequenced, and their results were aligned and analyzed using the nucleotide BLAST.

Results:
Overall, 224 fly larvae were isolated from 36 patients. According to the morphological analysis, all larvae were Oestrus ovis. Molecular analysis confirmed morphological results. Patients presenting acute conjunctivitis symptoms had a mean age of 34 ± 2 years, and there were four women (11%) and 32 men (89%). The highest incidence were recorded in the autumn season (55.8%). Morphological results of flies were confirmed by amplifying the expected size of the CO1 gene through conventional PCR.

Conclusion:
The cases of ophthalmomyiasis are higher than those mentioned in the published articles and this might be due to the absence of a regular monitoring program to care for the ophthalmomyiasis cases in the public health system. Therefore, due to the importance and potential incidence of this disease in Fars province, establishing a disease care program is necessary for the health surveillance system.
Caracterización del profesorado de educación superior que muestra eficacia docente
Authors: Murrieta Ortega Raymundo 
Published: March 2021

El objetivo de la investigación fue identificar las características de los profesores de educación superior que muestran eficacia docente; para ello, se aplicaron encuestas con escala tipo Likert a una muestra de 20 docentes y 480 alumnos de cinco licenciaturas de una escuela normal de la región centro de México. La investigación tuvo un enfoque cuantitativo, con diseño no experimental de tipo transeccional descriptivo, para lo que se tomó una muestra por conveniencia con la participación de profesores con resultados favorables y desfavorables en la evaluación docente en los últimos ciclos escolares. La pregunta de investigación formulada fue la siguiente: ¿cuáles son las características de eficacia docente del profesorado de una escuela normal en México desde la mirada de maestros y estudiantes?
Para analizar los resultados se establecieron tres dimensiones: a) personal, b) disciplinar y c) didáctico-pedagógica. Los resultados encontrados demuestran que la edad intermedia de los docentes (41 a 50 años), la experiencia en la docencia (de 16 a 30 años), determinados aspectos personales (disposición a la consulta y el ser humanista), rasgos disciplinares (preparación académica óptima y dominio de la asignatura), así como aspectos didáctico-pedagógicos (saber planear, organizar contenidos, crear ambientes de aprendizaje y realizar evaluación congruente) son factores vitales para que logren eficacia docente.
Drivers of Consumer Staying Intention Towards Islamic Green Hotel Industry: Evidence from Quantitative Findings
Authors: Aflah Isa  , Ain Syarmimi Mohd. Yusuf  , Razifah Othman  , Fairuz Husna Mohd Yusof  , Nurhafizah Azizan  
Published: March 2021

Insight Journal Vol. 7
DOI: 10.24191/ij.v7i1.58
This research study is endeavoured to discover the factors that will lead the consumers’ staying intention at green hotels, especially of those who practise the Shariah Law (Islamic green hotels). Nowadays, there has been an increase in public concern regarding environmental issues. Consumers are more environmentally aware than they were in past decades. Hotels are among the largest contributors of energy consumers in the tertiary building sector, which contribute to some negative impacts to the earth at the same time. The most obvious negative impact of hotels on environment are solid waste generation and disposal. Therefore, numerous consumers are supportive of green consumption and consider it as a successful method to protect the environment. In Islamic green hotels, Muslim-friendly amenities have also been provided to protect Muslims travellers’ welfare that is by providing them a comfortable prayer room, the Holy Quran and Islamic practices booklets, prayer mats and a direction of Qibla. A set of questionnaires was distributed to 256 respondents among the community and tourists in Kuching, Sarawak. The dependent variable in this study was consumers’ staying intention while the independent variables were green image, green satisfaction, Muslim amenities and lifestyle and price fairness. This research study also made use of the Statistical Package for Social Science (SPSS) software to analyse the result based on the questionnaires distributed to the respondents. Based on the result of analysis, it is shown that the green image and green satisfaction were found of having a positive significant that influence the consumers’ staying intention at the Islamic green hotels. Besides that, Muslim amenities and lifestyle was also found to have a positive significant impact that influences the consumers’ staying intention. Most Muslims were likely to choose a destination with Islamic practice to fulfil their daily duties. However, green price fairness did not significantly influence the consumers’ staying intention. This is because if green image, green satisfaction, Muslim amenities, and lifestyle meet the requirements of the Muslim tourists, they would not be affected by the price. As a matter of fact, price may be the least factor of consideration by the tourists in choosing a hotel to stay.
La última poesía de Jorge Riechmann y los males de la postmodernidad
Authors: Cimardi Ambra 
Published: March 2021

En el presente trabajo analizamos los últimos dos poemarios de Jorge Riechmann: El común de los mortales (2011) y Poemas lisiados (2012) desde el punto de vista de las teorías sobre la postmodernidad y del compromiso ecológico.
Relationship between capillary blood flow parameters measured in vivo and microrheologic parameters of blood measured in vitro in arterial hypertension and coronary heart disease
Authors: Kadanova I. M. , Neznanov A. I. , Lugovtsov A. Е. , Gurfinkel Yu. I. , Pigurenko A. A. , Dyachuk L. I. , Priezzhev A. V. 
Published: March 2021

Introduction. Blood microcirculation and its microrheologic properties are impaired in cardiovascular diseases. Microrheologic properties are characterized by the red blood cells (RBC) ability to aggregate and disaggregate. Therefore, the correlation studies between RBC aggregation and microcirculation disorders in pathologies are of interest for the development of theoretical concepts related to blood flow and for clinical practice.Aim. To analyze the correlation between capillary blood flow parameters measured in vivo and microrheologic blood parameters measured in vitro in patients suffering arterial hypertension (AH) and coronary heart disease (CHD).Materials and methods. We studied 3 groups of people: patients suffering AH, patients suffering AH+CHD and healthy donors. The characteristic aggregation time and aggregation index were measured in vitro by laser aggregometry. Analysis of capillary blood velocity (CBV) and assessment of the presence and absence of RBC aggregates in the nail bed capillaries were performed in vivo using vital digital capillaroscopy (VDC).Results. RBC aggregation for groups of patients suffering AH and AH+CHD was increased compared to the control group. Thus, in these patients groups, the characteristic aggregation time significantly decreases by an average of (38±13) %. Comparison of the results obtained using in vitro and in vivo methods showed the aggregation index for individuals with high CBV was significantly lower than for individuals with low CBV. The tendency is that the number of aggregates in the capillaries increases with a decrease in CBV.Conclusion. RBC aggregation is increased in groups of patients suffering AH and AH+CHD compared to the control group. The correlation between parameters measured in vitro and in vivo is evident for patients divided into subgroups according to parameters measured using the VDC. The obtained results allow us to conclude that the used methods are applicable in clinical practice.
Assessment of the forces of pair interaction of erythrocytes during their aggregation by the optical tweezers in Type 1 and Type 2 diabetes mellitus
Authors: Fabrichnova A. A. , Koshelev V. B. , Misnikova I. V. , Kovaleva Y. A. , Semenov A. N. , Lugovtsov A. E. , Kadanova I. M. , Neznanov A. I. , Priezzhev A. V. 
Published: March 2021

Objective. Measurement and comparison of the aggregation and disaggregation forces of individual erythrocytes during the formation or breakdown of a paired aggregate in vitro in the blood of patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) using the optical tweezers method. Materials and methods. A total of 50 people were included in the study. Of these, 10 people with T1DM (aged 28±15.8), 26 people with T2DM (aged 66±13). The control group consisted of 14 apparently healthy volunteers (46±21 years old). Measurements of the forces of pair interaction of erythrocytes in a diluted suspension were carried out in vitro by the method of dual-channel optical tweezers. The force of aggregation of erythrocytes FA (pN) and the force of disaggregation FD (pN) were measured and their ratio FD/FA was calculated.Results. The erythrocyte aggregation forces in the T1DM group did not differ significantly from the control group. However, the forces of disaggregation in the T1DM group were significantly lower than in the control group (p<0,05). The ratio of the forces of disaggregation to the forces of aggregation was lower in the T1DM group compared to the control group (p<0.005). In T2DM group, erythrocyte aggregation forces were higher compared to the control group (p<0.005). At the same time, the ratios of the forces of disaggregation to the forces of aggregation in T1DM group and T2DM group did not differ.Conclusion. Both T1DM group and T2DM group are characterized by hyperaggregation of erythrocytes. However, given the data obtained, it can be assumed that the mechanisms of such hyperaggregation are different.