bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoplastic synovial lining cells that coexpress podoplanin and CD90 overproduce CSF‐1, driving tenosynovial giant cell tumor
Authors: Chandler Andrew C. , Yakoub Mohamed , Fujiwara Tomohiro , Donlin Laura T. , Purdue Paul Edward , Healey John H. 
Published: December 2021

AbstractTenosynovial giant cell tumor (TCGT) is a rare neoplasm affecting the synovium of joints, bursae, and tendon sheaths. The overproduction of colony‐stimulating factor‐1 (CSF‐1) by a minority of the tumor population works in a paracrine fashion to drive tumor growth. Pathology of the reactive, monocytic component has been well elucidated, whereas the populations of neoplastic cells and all the sources of CSF‐1 overproduction are incompletely characterized. Podoplanin (PDPN), or gp38, is a cell surface glycoprotein that is expressed on fibroblast‐like synovial cells and upregulated in rheumatoid arthritis and many cancers; it governs cell mobility, epithelial–mesenchymal transition, and other functions and is associated with lymphangiogenesis and poor prognosis in many solid tumors, which underscores its local and possible systemic effects. We found higher PDPN expression in TGCT than in internal controls of patients' healthy synovium. Flow cytometry partitioned PDPNhigh cells into PDPNhighCD90+ and PDPNhighCD14+ populations. Quantitative real‐time polymerase chain reaction analysis of the PDPNhighCD90+ cells revealed that CSF‐1 expression was 10‐fold higher than in PDPNhighCD14+ cells. Therefore, we conclude that the lining fibroblast‐like synovial cells, which express PDPNhighCD90+, are responsible for the overproduction of CSF‐1 and for driving tumor growth.
Elaboration and characterization of nanoemulsion with orange essential oil and pectin
Authors: Sanchez Antonio , García María Carmen , Martín‐Piñero María José , Muñoz José , Alfaro‐Rodríguez Maria‐Carmen 
Published: December 2021

AbstractBACKGROUNDNanoemulsions formulated with citric essential oils are currently of interest because of their physical and chemical properties and multiple applications in areas such as the food industry or agrochemicals. These are thermodynamically unstable and have almost Newtonian flow behaviour, but a suitable formulation allows systems to be obtained with good physical stability and rheological properties. The addition of pectin makes this possible. In this work, food nanoemulsions formulated with pectin, orange essential oil (5 wt%), and Tween 80 were obtained by microfluidization. First, the effect of Tween 80 concentration from 1 to 5 wt% on emulsions without pectin was evaluated. Then, pectin was added to the most stable nanoemulsion obtained and two variables were studied: the pectin solution concentration (from 2 to 6 wt%) and the pectin/emulsion ratio (1:1 or 2:1) at a fixed pectin concentration.RESULTSRheological, laser diffraction, and multiple light scattering techniques were employed to determine the content of Tween 80 that results in the most stable nanoemulsion without pectin, which was 3 wt%. In addition, these techniques were used to determine the structure and physical stability of the nanoemulsions containing orange essential oil and pectin. The results obtained showed that the emulsions containing 2 wt% pectin were destabilized before 24 h. Furthermore, the emulsion with 6 wt% pectin and a 2:1 pectin/emulsion ratio showed the highest viscosity and the lowest mean diameters, and therefore the greatest stability.CONCLUSIONThis work extends the knowledge of formulation of nanoemulsions and using essential oils. © 2021 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Genotypic differences in the synergistic effect of nitrogen and boron on the seed yield and nitrogen use efficiency of Brassica napus
Authors: Wang Youqiang , Zhao Zhe , Wang Sheliang , Shi Lei , Xu Fangsen 
Published: December 2021

AbstractBACKGROUNDRapeseed (Brassica napus) is highly sensitive to nitrogen (N) and boron (B) deficiency; however, the synergistic effects of these elements on rapeseed production are poorly understood. The aim of this study was to investigate the effects of co‐application of N and B on seed yield, N uptake and N use efficiency (NUE) of rapeseed. Three rapeseed cultivars (W10, ZS11 and HG) were treated with different N and B application rates, and the seed yield, N uptake and NUE were examined in 2‐year field experiments.RESULTSThe application of B fertilizer (4.5, 9 kg borax ha−1) improved N uptake, NUE and seed yield. However, the magnitude of increase in seed yield by B fertilization was dependent upon the rate of N supply and genotype. The benefit of B was much greater at 180 kg N ha−1 than at 0 or 60 kg N ha−1. The combination of N and B also improved N remobilization from sources (stems and husks) to sinks (seeds) and increased N recovery efficiency (NRE). Compared with the B‐inefficient cultivar W10, the B‐efficient cultivars ZS11 and HG were superior in growth, seed yield, N uptake and NUE on B deficient soils. Furthermore, B‐efficient cultivars showed great potential in saving N input, and the yield increased by more than 40% under B deficiency conditions.CONCLUSIONThis study highlights a markedly synergistic effect of N and B nutrition on rapeseed NUE and yield production and shows that B‐efficient genotypes can increase yield and reduce N inputs under B‐deficient conditions. © 2021 Society of Chemical Industry.
Management of postoperative microvascular compromise and ischemia reperfusion injury in breast reconstruction using autologous tissue transfer: Retrospective review of 2103 flaps
Authors: Coriddi Michelle , Myers Paige , Mehrara Babak , Nelson Jonas , Cordeiro Peter G. , Disa Joseph , Matros Evan , Dayan Joseph , Allen Robert , McCarthy Colleen 
Published: December 2021

AbstractBackgroundAlthough rates of microvascular thrombosis following free‐flap breast reconstruction are low, debate persists about the optimal methods to restore blood flow and prevent ensuing flap shrinkage or fibrosis. Here we evaluate our management of microvascular compromise, including both a review of our approach for restoring blood flow and addressing the ensuing inflammatory changes following ischemia reperfusion.MethodsWe conducted a retrospective review of autologous free tissue transfer breast reconstructions from 1/2010 to 1/2020. Patients who had flaps requiring take‐back for salvage were identified. Management of microvascular compromise and ischemia reperfusion injury were recorded.ResultsOf 2103 flaps were used in the breast reconstructions, 47 flaps required take‐back for microvascular compromise (2.2%). Most flaps were either completely salvaged (n = 29, 61.7%) or partially salvaged (n = 5, 10.6%). Thirteen (27.7%) were a total flap loss, for an overall rate of 0.8% (including 3 flaps with no salvage attempt). Management of microvascular compromise most often included revision of the anastomosis (n = 33, 70.2%), thrombectomy (n = 27, 57.4%), tissue plasminogen activator administration (n = 26, 55.3%), and vein grafts (n = 18, 38.3%). Management of ischemia reperfusion included intraoperative steroids (n = 33, 70.2%), postoperative steroids (n = 17, 38.6%), and postoperative therapeutic anticoagulation (n = 27, 61.3%). Of 34 salvaged flaps, 5 (14.7%) had partial flap loss and/or fat necrosis on clinical examination at an average follow‐up of 2.7 ± 2.8 years.ConclusionsSalvage of microvascular compromise in autologous breast reconstruction should include restoration of blood flow and management of ischemia reperfusion injury. Attention to both is paramount for successful outcomes.
Eight‐node hexahedral elements for gradient elasticity analysis
Authors: Yuan Wenchen , Sze Kam Yim 
Published: December 2021

AbstractComputational analysis of gradient elasticity often requires the trial solution to be C1 yet constructing C1 finite elements is not trivial. Further to the recent success of 4‐node quadrilateral and 4‐node tetrahedral elements which employ only displacement and displacement gradient as the nodal dofs, this paper develops 8‐node hexahedral elements for gradient elasticity analyses by the generalized discrete Kirchhoff and the relaxed hybrid‐stress methods. Both methods require a C0 displacement interpolation which is quadratic complete in the Cartesian coordinates. Starting from the 8‐node hexahedron with only displacement and displacement gradient as the nodal dofs, it is noted that another 6 mid‐face nodes and a condensable bubble node with displacement dofs are required for the quadratic completeness. The dofs of the mid‐face node are then constrained to those of the corner nodes defining the same element face. The C0 displacement of the resultant 8‐node hexahedron is quadratic complete only when all element faces are flat. Though the quadratic completeness of the two 8‐node elements has been partially compromised, the relaxed hybrid‐stress element model is marginally more accurate than the previously devised 4‐node tetrahedral elements.
Association between the examination rate of treatment‐resistant schizophrenia and the clozapine prescription rate in a nationwide dissemination and implementation study
Authors: Yasui‐Furukori Norio , Muraoka Hiroyuki , Hasegawa Naomi , Ochi Shinichiro , Numata Shusuke , Hori Hikaru , Hishimoto Akitoyo , Onitsuka Toshiaki , Ohi Kazutaka , Hashimoto Naoki , Nagasawa Tatsuya , Takaesu Yoshikazu , Inagaki Takahiko , Tagata Hiromi , Tsuboi Takashi , Kubota Chika , Furihata Ryuji , Iga Jun‐ichi , Iida Hitoshi , Miura Kenichiro , Matsumoto Junya , Yamada Hisashi , Watanabe Koichiro , Inada Ken , Shimoda Kazutaka , Hashimoto Ryota 
Published: December 2021

AbstractBackgroundThe decision to initiate clozapine treatment should be made on an individual basis and may be closely related to the early detection of treatment‐resistant schizophrenia (TRS), although there is evidence that the early use of clozapine results in a better response to treatment. Therefore, we investigated the relationship between the examination rate of TRS and the prescription rate of clozapine.MethodsAfter attending a 1‐day educational program on schizophrenia based on the "Guidelines for the Pharmacological Treatment of Schizophrenia," we asked the participating facilities to submit records of whether or not TRS was evaluated for each patient. We calculated the clozapine prescription rate from the schizophrenic patients prescribed clozapine and all of the schizophrenic patients. Forty‐nine facilities in 2017 were included in the study.ResultsThere were dichotomous distributions in the examination rate of TRS and a non‐normal distribution in the prescription rate of clozapine. There was a significant correlation between the prescription rate of clozapine and the examination rate of TRS (r
s = 0.531, P = 1.032 × 10−4). A significant difference was found in the prescription rate of clozapine between the three groups of facilities according to the examination rate of TRS.ConclusionAs a preliminary problem for the use of clozapine, in Japan, the examination rate of TRS varies, and there are many facilities that typically do not consider the possibility of TRS; this trend leads to a low rate of clozapine use. Clearly, further clinician training is needed for the early detection and appropriate management of TRS that includes an explanation of TRS and how to introduce clozapine therapy to patients and their families.
Pediatric AML patients with acute‐onset cardiomyopathy in the setting of Streptococcus viridans bacteremia after anthracyclines
Authors: Sabet Kazuhiro , Panigrahi Arun , Chung Jo , Dayan Yoni 
Published: December 2021

AbstractWe reviewed three very similar cases of acute‐onset heart failure in children with acute myeloid leukemia who received anthracyclines during their treatment. All three children were diagnosed with recent Streptococcus viridans bacteremia and had persistent tachycardia prior to acute‐onset heart failure with near‐complete resolution within weeks. We hypothesize their heart failure was secondary to sepsis‐induced cardiomyopathy with anthracycline‐induced cardiac myocyte damage as a predisposing factor. We suggest prophylaxis and methods of early detection to prevent and better treat acute heart failure in pediatric oncology patients receiving anthracyclines.
Positivity, creativity, and reappraisal's emotion regulation efficacy
Authors: Li Yue , Zhang Ze , Wang Yuechen , Guo Tingting , Zhang Ying , Li Ziyi , Luo Jing 
Published: December 2021

AbstractThe relationship between cognitive reappraisal's creativity (both novelty and appropriateness), positivity (the positive or negative attitudes), and emotion regulation efficacy was analyzed. Positivity was found to play a full mediating role between creativity and regulation effectiveness.
Improved blood glucose control, cardiovascular health and empowerment in people attending X‐PERT structured diabetes education
Authors: Wheatley Sean D , Arjomandkhah Nicola C , Murdoch Campbell , Whitaker Matthew JG , Evans Nina M , Hollinrake Paul B , Reeves Trudi E , Wellsted David , Deakin Trudi A 
Published: December 2021

AbstractThe aim of the audit was to assess the change in key health markers in people with, or at risk of, diabetes who attended X‐PERT structured diabetes education.Data from X‐PERT programmes are entered into a central database. Twelve‐month changes in anthropometric and clinical variables – and diabetes medication usage – are reported for programmes run between 1 January 2017 and 31 December 2018. Where appropriate, paired t‐tests were performed.In total, 29,703 participants were registered to attend a programme during this period, of which 23,118 (78%) attended at least one session. Of those who attended at least one session 18,039 (78%) completed a programme. Ninety‐nine percent (3342) of participants with clinical data available had type 2 diabetes. Meaningful reductions in HbA1c were seen (‐8.6mmol/mol, 95% CI ‐9.2 to ‐8.0mmol/mol [‐0.8%, 95% CI ‐0.8 to ‐0.7%]; n=2957; p<0.001); and there were statistically significant reductions in body weight, BMI, waist circumference, fasting blood glucose, total cholesterol, low‐density lipoprotein cholesterol, triglycerides, total cholesterol to high‐density lipoprotein cholesterol ratio, and triglycerides to high‐density lipoprotein cholesterol ratio (all p<0.001). No change in high‐density lipoprotein cholesterol was observed. Of the 1180 participants who were recorded as taking diabetes medication at baseline, 632 (54%) were able to reduce the number of medications they were taking and 278 (24%) were able to omit them entirely. Participant empowerment score increased by 20%.Improvements in glycaemic control, weight management and cardiovascular disease risk, as well as reduced medication requirements and an increased feeling of empowerment, were observed in people who attended X‐PERT structured diabetes education programmes. Copyright © 2021 John Wiley & Sons.
Hierarchical cluster analysis of herbicide modes of action reveals distinct classes of multiple resistance in weeds
Authors: Hulme Philip E 
Published: December 2021

AbstractBACKGROUNDThe number of weed species resistant to multiple herbicide modes of action (MoAs) has increased over the last 30 years and may in the future render existing herbicide MoAs obsolete for many cropping systems. Yet few predictive tools exist to manage this risk. Using a worldwide dataset of weed species resistant to multiple herbicide MoAs, hierarchical clustering was used to classify MoAs into similar groups in relation to the suite of resistant weed species they have in common. Network analyses then were used to explore the relative importance of species prevalence and similarity in cluster patterns.RESULTSHierarchical clustering identified three similarly sized clusters of herbicide MoAs that were linked by the co‐occurrence of resistant weeds: Herbicide Resistance Action Committee (HRAC) groups 2, 4, 5 and 9; HRAC groups 12, 14 and 15; and HRAC groups 1, 3 and 22. Cluster membership was consistent with similarities in the physiological or biochemical target of the herbicide MoAs. Network analyses revealed that the number of weed species resistant to two different MoAs was related to the number of weeds known to be resistant to each individual herbicide MoA.CONCLUSIONSHierarchical cluster analysis provided new insights into the risk of weeds becoming resistant to more than one herbicide MoA. By clustering herbicide MoAs into three distinct groups, the potential exists for farmers to manage resistance by rotating herbicides between rather than within clusters, as far as crop, weed and environmental conditions allow.
COVID‐19‐induced adult multisystem inflammatory syndrome and fatal acute limb ischaemia
Authors: Kobe Hiroshi , Ito Akihiro , Ishida Tadashi 
Published: December 2021

Key messageA case of coronavirus disease 2019 (COVID‐19)‐induced adult multisystem inflammatory syndrome (MIS) and fatal acute limb ischaemia is presented. Arterial thrombosis and MIS are reported as complications of COVID‐19. This case further highlights that arterial thrombosis and MIS can occur in COVID‐19.
Using Small Molecule Absorbers to Create a Photothermal Wax Motor
Authors: Lui Brandon F. , Bardeen Christopher J. 
Published: December 2021

AbstractOrganic phase change materials are used in actuators like wax motors. The solid→liquid phase transition that drives expansion is commonly induced by resistive heating that requires an electrical connection. The use of light to generate a phase change provides a non‐contact way to power wax motors. Here, it is demonstrated that small molecules can act as absorbers to enable a photoinduced solid→liquid melting transition in eicosane, a low molecular weight phase change material. Three different small molecule absorbers are utilized: (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO), azobenzene (AZOB), and guaiazulene (GAZ). The GAZ/eicosane mixture is characterized in detail because its absorption extends out to 750 nm, opening up the possibility of using near‐infrared diodes as the photon source. The GAZ/eicosane composite is incorporated into a commercial wax motor assembly and 532 nm laser light is used to lift up to 400 g. The temporal response, work and force output, and efficiency are measured, and no loss of lifting capability or degradation is observed after ten cycles of irradiation. The incorporation of small aromatic molecules with low‐energy absorption features into phase change materials can provide a general way to make light powered wax motors.
Co4N‐Decorated 3D Wood‐Derived Carbon Host Enables Enhanced Cathodic Electrocatalysis and Homogeneous Lithium Deposition for Lithium–Sulfur Full Cells
Authors: Zhang Weifeng , Xu Biyi , Zhang Longhai , Li Wei , Li Shulian , Zhang Jiaxi , Jiang Guoxing , Cui Zhiming , Song Huiyu , Grundish Nicholas , Shi Kaixiang , Zhang Bingkai , Fan Yan , Pan Feng , Liu Quanbing , Du Li 
Published: December 2021

AbstractThe sluggish kinetics of sulfur conversion in the cathode and the nonuniform deposition of lithium metal at the anode result in severe capacity decay and poor cycle life for lithium–sulfur (Li–S) batteries. Resolving these deficiencies is the most direct route toward achieving practical cells of this chemistry. Herein, a vertically aligned wood–derived carbon plate decorated with Co4N nanoparticles host (Co4N/WCP) is proposed that can serve as a host for both the sulfur cathode and the metallic lithium anode. This Co4N/WCP electrode host drastically enhances the reaction kinetics in the sulfur cathode and homogenizes the electric field at the anode for the uniform lithium plating. Density functional theory calculations confirm the experimental observations that Co4N/WCP provides a lower energy barrier for the polysulfide redox reaction in the cathode and a low adsorption energy for lithium deposition at the anode. Employing the Co4N/WCP host at both electrodes in a S@Co4N/WCP||Li@Co4N/WCP full cell delivers a specific capacity of 807.9 mAh g−1 after 500 cycles at a 1 C rate. Additional experiments are performed with high areal sulfur loading of 4 mg cm−2 to demonstrate the viability of this strategy for producing practical Li–S cells.
Rotating Cylinder‐Assisted Nanoimprint Lithography for Enhanced Chemisorbable Filtration Complemented by Molecularly Imprinted Polymers
Authors: Jeon Sangheon , Park Rowoon , Jeong Jeonghwa , Heo Gyeonghwa , Lee Jihye , Shin Min Chan , Kwon Young Woo , Yang Jin Chul , Park Woon Ik , Kim Ki Su , Park Jinyoung , Hong Suck Won 
Published: December 2021

AbstractRotating cylindrical stamp‐based nanoimprint technique has many advantages, including the continuous fabrication of intriguing micro/nanostructures and rapid pattern transfer on a large scale. Despite these advantages, the previous nanoimprint lithography has rarely been used for producing sophisticated nanoscale patterns on a non‐planar substrate that has many extended applications. Here, the simple integration of nanoimprinting process with a help of a transparent stamp wrapped on the cylindrical roll and UV optical source in the core to enable high‐throughput pattern transfer, particularly on a fabric substrate is demonstrated. Moreover, as a functional resin material, this innovative strategy involves a synergistic approach on the synthesis of molecularly imprinted polymer, which are spatially organized free‐standing perforated nanostructures such as nano/microscale lines, posts, and holes patterns on various woven or nonwoven blank substrates. The proposed materials can serve as a self‐encoded filtration medium for selective separation of formaldehyde molecules. It is envisioned that the combinatorial fabrication process and attractive material paves the way for designing next‐generation separation systems in use to capture industrial or household toxic substances.
Highly Reversible Cycling of Zn‐MnO2 Batteries Integrated with Acid‐Treated Carbon Supportive Layer
Authors: Kim Byung Gon , Park Sang Wook , Choi Hong Jun , Park Jun‐Woo , Lee Hongkyung , Choi Jeong‐Hee 
Published: December 2021

AbstractZn‐MnO2 battery with mild‐acid electrolytes has been considered as a promising alternative to Li‐ion battery for safe and cost‐effective energy storage systems (ESSs), and for full electrification. However, the governing mechanism of MnO2 electrochemistry has not been fully elucidated, hindering further advances in highly reversible MnO2 cathodes. Eventual Mn2+ ion dissolution into the electrolyte adversely triggers the irreversible loss of Mn2+ ions and the excessive precipitation of zinc hydroxyl sulfate (Zn4SO4(OH)6·xH2O, ZHS), leading to irreversible capacity loss upon prolonged cycling. To overcome these drawbacks, a rationally renovated cell structure is proposed by integrating an acid‐treated carbon supportive layer (aCSL) in the MnO2 cathode, which can play multifunctional roles rendering the additional reaction sites for the reversible formation/decomposition of ZHS and re‐utilization of the dissolved Mn2+ ions. Furthermore, the improved affinity of the aCSL toward the electrolyte is beneficial for increasing active surface area and facilitating charge transfer at the cathode side. Benefiting from these features, compared to the conventional cell configuration, the aCSL‐integrated Zn‐MnO2 cell exhibits superior cycling over 3000 cycles with negligible capacity decay (85.6% retention) at a current of 3 A g−1.