bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemophagocytosis, hyper-inflammatory responses, and multiple organ damages in COVID-19-associated hyperferritinemia
Authors: Dong Guiying , Yu Jianbo , Gao Weibo , Guo Wei , Zhu Jihong , Wang Tianbing 
Published: December 2021

Abstract
Hyperferritinemia comes to light frequently in general practice. However, the characteristics of COVID-19-associated hyperferritinemia and the relationship with the prognosis were not well described. The retrospective study included 268 documented COVID-19 patients. They were divided into the hyperferritinemia group (≥ 500 µg/L) and the non-hyperferritinemia group (< 500 µg/L). The prevalence of fever and thrombocytopenia and the proportion of patients with mechanical ventilator support and in-hospital death were much higher in the hyperferritinemia group (P < 0.001). The hyperferritinemia patients showed higher median IL-6, D-dimer, and hsCRP (P < 0.001) and lowered FIB level (P = 0.036). The hyperferritinemia group had a higher proportion of patients with AKI, ARDS, and CSAC (P < 0.001). According to the multivariate analysis, age, chronic pulmonary disease, and hyperferritinemia were found to be significant independent predictors for in-hospital mortality [HR 1.041 (95% CI 1.015–1.068), P = 0.002; HR 0.427 (95% CI 0.206–0.882), P = 0.022; HR 6.176 (95% CI 2.447–15.587), P < 0.001, respectively]. The AUROC curve was 0.88, with a cut-off value of ≥ 971 µg/L. COVID-19 patients with hyperferritinemia had a high proportion of organ dysfunction, were more likely to show hyper-inflammation, progressed to hemophagocytic lymphohistiocytosis, and indicated a higher proportion of death.
The outcome of patients with inflammatory bowel disease–associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer–a matched-pair analysis of survival
Authors: Vitali Francesco , Wein Axel , Rath Timo , Eckstein Markus , Neufert Clemens , Siebler Jürgen , Atreya Raja , Hartmann Arndt , Hohenberger Werner , Weber Klaus , Neurath Markus Friedrich , Grützmann Robert , Merkel Susanne 
Published: December 2021

Abstract
Purpose
Patients with inflammatory bowel disease (IBD) have an increased risk for colorectal cancer (CRC). In IBD patients, cancer is often diagnosed in advanced stages and conflicting data on survival compared to sporadic CRC have been reported. The aim of this study was to directly compare clinical characteristics and prognosis of patients with IBD-CRC and sporadic CRC.

Methods
The clinical and pathological data of 63 patients with IBD-CRC and 3710 patients with sporadic CRC treated at the University Hospital of Erlangen between 1995 and 2015 were compared. Forty-seven M0 patients with IBD were matched with sporadic CRC patients after curative resection (R0) according to tumor localization, stage, sex, and year of treatment. Overall and disease-free survival were compared.

Results
Sixty-three patients presented IBD-CRC. Fifty were affected with ulcerative colitis (UC) and 13 with Crohn’s disease (CD). CRC was diagnosed within 1.45 years since last endoscopic surveillance. Twelve patients (19%) had a diagnosis of primary sclerosing cholangitis. In matched analysis, IBD patients were diagnosed with CRC at younger age compared to sporadic CRC and were more likely to have right-sided CRC (40% versus 23.3%) and rare histological subtypes (19% versus 9.2%). No differences in 5-year overall (78.7 versus 80.9 months) and 5-year disease-free survival (74.5 versus 70.2 months) were noted.

Conclusion
IBD-CRC patients were younger and more frequently had right-sided carcinomas compared to sporadic CRC. CRC in IBD patients did not show survival difference compared to matched-pair sporadic CRC patients without distant metastases after curative resection. Surveillance might be important for early detection of CRC in IBD patients.
Improving morphological outcome in lamellar macular hole surgery by using highly concentrated autologous platelet-rich plasma
Authors: Hagenau Felix , Luft Nikolaus , Nobl Matthias , Vogt Denise , Klaas Julian E. , Schworm Benedikt , Siedlecki Jakob , Kreutzer Thomas C. , Priglinger Siegfried G. 
Published: December 2021

Abstract
Purpose
To evaluate the use of highly concentrated autologous platelet-rich plasma (PRP) in lamellar macular hole (LMH) surgery with regard to function and morphology.

Methods
We included 12 eyes of 12 patients with progressive LMH in this interventional case series. After 23/25-gauge pars plana vitrectomy, 0.1ml highly concentrated autologous platelet-rich plasma was applied under air tamponade. Induction of posterior vitreous detachment and peeling of tractive epiretinal membranes were performed whenever present. Phacovitrectomy was undertaken in cases of phakic lens status. Postoperatively, all patients were instructed to rest in a supine position for the first two postoperative hours. Best-corrected visual acuity (BCVA) testing, microperimetry, spectral-domain optical coherence tomography (SD-OCT), and fundus photography were carried out preoperatively and 6 months postoperatively.

Results
Foveal configuration was restored in 10 of 12 patients (83.3%) at 6 months postoperatively. Two patients who had not undergone ILM peeling showed a recurring defect at 6-month follow-up. Best-corrected visual acuity improved significantly from 0.29 ± 0.08 to 0.14 ± 0.13 logMAR (Wilcoxon: p=0.028). Microperimetry remained unchanged (23.38 ± 2.53 preoperatively; 23.0 ± 2.49 dB postoperatively; p=0.67). No patient experienced vision loss after surgery, and no significant intra- or postoperative complications occurred.

Conclusion
The application of PRP in the surgical therapy of LMH results in good morphological and functional outcomes. Additional peeling of the ILM seems to be mandatory when using PRP to prevent the recurrence of LMH. Strict postoperative supine positioning for 2 h avoids PRP dislocation. Larger sample sizes are needed to confirm the results.
Graft survival of Descemet membrane endothelial keratoplasty (DMEK) in corneal endothelial decompensation after glaucoma surgery
Authors: Schrittenlocher Silvia , Grass C. , Dietlein T. , Lappas A. , Matthaei M. , Cursiefen C. , Bachmann B. 
Published: December 2021

Abstract

Purpose
This study aims to assess the results, rebubbling rate, and graft survival after Descemet membrane endothelial keratoplasty (DMEK) with regard to the number and type of previous glaucoma surgeries.

Methods
This is a clinical retrospective review of 1845 consecutive DMEK surgeries between 07/2011 and 08/2017 at the Department of Ophthalmology, University of Cologne. Sixty-six eyes were included: group 1 (eyes with previous glaucoma drainage devices (GDD); n = 27) and group 2 (eyes with previous trabeculectomy (TE); n = 39). Endothelial cell loss (ECL), central corneal thickness, graft failure, rebubbling rate, and best spectacle-corrected visual acuity (BSCVA) up to 3 years after DMEK were compared between subgroups of patients with different numbers of and the two most common types of glaucoma surgeries either GDD or TE or both.

Results
Re-DMEK rate due to secondary graft failure was 55.6% (15/27) in group 1 and 35.9% in group 2. The mean graft survival time in group 1 was 25 ± 11 months and 31.3 ± 8.6 months in group 2 (p = 0.009).
ECL in surviving grafts in group 1 was 35% (n = 13) at 6 months, 36% at 12 months (n = 8), and 27% (n = 4) at 2 years postoperatively. In group 2, ECL in surviving grafts was 41% (n = 10) at 6 months, 36% (n = 9) at 12 months, and 38% (n = 8) at 2 years postoperatively. Rebubbling rate in group 1 was 18.5% (5/27) and 35.9% (14/39) in group 2 (p = 0.079).

Conclusion
Eyes with previous GDD had no higher risk for an increased rebubbling rate but a higher risk for a re-DMEK due to secondary graft failure with a mean transplant survival time of about 2 years. Compared to eyes with preexisting glaucoma drainage device, eyes after trabeculectomy had less secondary graft failures and a longer mean graft survival rate.
Standardized single-incision plus one-port laparoscopic left lateral sectionectomy: a safe alternative to the conventional procedure
Authors: Katagiri Hirokatsu , Nitta Hiroyuki , Takahara Takeshi , Hasegawa Yasushi , Kanno Syoji , Umemura Akira , Takeda Daiki , Makabe Kenji , Kikuchi Koji , Kimura Taku , Yanari Shingo , Sasaki Akira 
Published: December 2021

Abstract

Purpose
Laparoscopic left lateral sectionectomy (LLLS) is a feasible and safe procedure with a relatively smooth learning curve. However, single-incision LLLS requires extensive surgical experience and advanced techniques. The aim of this study is to report the standardized single-incision plus one-port LLLS (reduced port LLLS, RPLLLS) technique and evaluate its safety, feasibility, and effectiveness for junior surgeons.

Methods
Between January 2008 and November 2020, the clinical records of 49 patients who underwent LLLS, divided into the conventional LLLS (n = 37) and the RPLLLS group (n = 12), were retrospectively reviewed. The patient characteristics, pathologic results, and operative outcomes were evaluated.

Results
A history of previous abdominal surgery in the RPLLLS group was significantly high (56.8% vs. 91.7%, p = 0.552). Notably, junior surgeons performed 62.2% of the conventional LLLSs and 58.4% of the standardized RPLLLSs. There were no significant differences between the two groups in terms of median operative time (121.0 vs. 113.5, p = 0.387), median blood loss (13.0 vs. 8.5, p = 0.518), median length of hospital stays (7.0 vs. 7.0, p = 0.408), and morbidity rate (2.7% vs. 0%, p = 0.565), respectively.

Conclusion
This standardized RPLLLS is a feasible and safe alternative to conventional LLLS and may become the ideal training procedure for both junior surgeons and surgeons aiming to learn more complex procedures.
What makes a good prediction? Feature importance and beginning to open the black box of machine learning in genetics
Authors: Musolf Anthony M. , Holzinger Emily R. , Malley James D. , Bailey-Wilson Joan E. 
Published: December 2021

AbstractGenetic data have become increasingly complex within the past decade, leading researchers to pursue increasingly complex questions, such as those involving epistatic interactions and protein prediction. Traditional methods are ill-suited to answer these questions, but machine learning (ML) techniques offer an alternative solution. ML algorithms are commonly used in genetics to predict or classify subjects, but some methods evaluate which features (variables) are responsible for creating a good prediction; this is called feature importance. This is critical in genetics, as researchers are often interested in which features (e.g., SNP genotype or environmental exposure) are responsible for a good prediction. This allows for the deeper analysis beyond simple prediction, including the determination of risk factors associated with a given phenotype. Feature importance further permits the researcher to peer inside the black box of many ML algorithms to see how they work and which features are critical in informing a good prediction. This review focuses on ML methods that provide feature importance metrics for the analysis of genetic data. Five major categories of ML algorithms: k nearest neighbors, artificial neural networks, deep learning, support vector machines, and random forests are described. The review ends with a discussion of how to choose the best machine for a data set. This review will be particularly useful for genetic researchers looking to use ML methods to answer questions beyond basic prediction and classification.
Quenched local central limit theorem for random walks in a time-dependent balanced random environment
Authors: Deuschel Jean-Dominique , Guo Xiaoqin 
Published: December 2021

AbstractWe prove a quenched local central limit theorem for continuous-time random walks in $${\mathbb {Z}}^d, d\ge 2$$

Z

d

,
d
≥
2

, in a uniformly-elliptic time-dependent balanced random environment which is ergodic under space-time shifts. We also obtain Gaussian upper and lower bounds for quenched and (positive and negative) moment estimates of the transition probabilities and asymptotics of the discrete Green’s function.
How can surgical skills in laparoscopic colon surgery be objectively assessed?—a scoping review
Authors: Haug Tora Rydtun , Ørntoft Mai-Britt Worm , Miskovic Danilo , Iversen Lene Hjerrild , Johnsen Søren Paaske , Madsen Anders Husted 
Published: December 2021

Abstract
Background
In laparoscopic colorectal surgery, higher technical skills have been associated with improved patient outcome. With the growing interest in laparoscopic techniques, pressure on surgeons and certifying bodies is mounting to ensure that operative procedures are performed safely and efficiently. The aim of the present review was to comprehensively identify tools for skill assessment in laparoscopic colon surgery and to assess their validity as reported in the literature.

Methods
A systematic search was conducted in EMBASE and PubMed/MEDLINE in May 2021 to identify studies examining technical skills assessment tools in laparoscopic colon surgery. Available information on validity evidence (content, response process, internal structure, relation to other variables, and consequences) was evaluated for all included tools.

Results
Fourteen assessment tools were identified, of which most were procedure-specific and video-based. Most tools reported moderate validity evidence. Commonly not reported were rater training, assessment correlation with variables other than training level, and validity reproducibility and reliability in external educational settings.

Conclusion
The results of this review show that several tools are available for evaluation of laparoscopic colon cancer surgery, but few authors present substantial validity for tool development and use. As we move towards the implementation of new techniques in laparoscopic colon surgery, it is imperative to establish validity before surgical skill assessment tools can be applied to new procedures and settings. Therefore, future studies ought to examine different aspects of tool validity, especially correlation with other variables, such as patient morbidity and pathological reports, which impact patient survival.
Amplified parallel antigen rapid test for point-of-care salivary detection of SARS-CoV-2 with improved sensitivity
Authors: Tng Danny Jian Hang , Yin Bryan Chu Yang , Cao Jing , Ko Kwan Ki Karrie , Goh Kenneth Choon Meng , Chua Delia Xue Wen , Zhang Yong , Chua Melvin Lee Kiang , Low Jenny Guek Hong , Ooi Eng Eong , Soo Khee Chee 
Published: December 2021

AbstractIn
the ongoing COVID-19 pandemic, simple, rapid, point-of-care tests not requiring trained personnel for primary care testing are essential. Saliva-based antigen rapid tests (ARTs) can fulfil this need, but these tests require overnight-fasted samples; without which independent studies have demonstrated sensitivities of only 11.7 to 23.1%. Herein, we report an Amplified Parallel ART (AP-ART) with sensitivity above 90%, even with non-fasted samples. The virus was captured multimodally, using both anti-spike protein antibodies and Angiotensin Converting Enzyme 2 (ACE2) protein. It also featured two parallel flow channels. The first contained spike protein binding gold nanoparticles which produced a visible red line upon encountering the virus. The second contained signal amplifying nanoparticles that complex with the former and amplify the signal without any linker. Compared to existing dual gold amplification techniques, a limit of detection of one order of magnitude lower was achieved (0.0064 ng·mL–1). AP-ART performance in detecting SARS-CoV-2 in saliva of COVID-19 patients was investigated using a case–control study (139 participants enrolled and 162 saliva samples tested). Unlike commercially available ARTs, the sensitivity of AP-ART was maintained even when non-fasting saliva was used. Compared to the gold standard reverse transcription-polymerase chain reaction testing on nasopharyngeal samples, non-fasting saliva tested on AP-ART showed a sensitivity of 97.0% (95% CI: 84.7–99.8); without amplification, the sensitivity was 72.7% (95% CI: 83.7–94.8). Thus, AP-ART has the potential to be developed for point-of-care testing, which may be particularly important in resource-limited settings, and for early diagnosis to initiate newly approved therapies to reduce COVID-19 severity.
Graphical abstract
Adapting k-means for graph clustering
Authors: Sieranoja Sami , Fränti Pasi 
Published: December 2021

AbstractWe propose two new algorithms for clustering graphs and networks. The first, called K‑algorithm, is derived directly from the k-means algorithm. It applies similar iterative local optimization but without the need to calculate the means. It inherits the properties of k-means clustering in terms of both good local optimization capability and the tendency to get stuck at a local optimum. The second algorithm, called the M-algorithm, gradually improves on the results of the K-algorithm to find new and potentially better local optima. It repeatedly merges and splits random clusters and tunes the results with the K-algorithm. Both algorithms are general in the sense that they can be used with different cost functions. We consider the conductance cost function and also introduce two new cost functions, called inverse internal weight and mean internal weight. According to our experiments, the M-algorithm outperforms eight other state-of-the-art methods. We also perform a case study by analyzing clustering results of a disease co-occurrence network, which demonstrate the usefulness of the algorithms in an important real-life application.
Developing a pragmatic evaluation of ICTs for older adults with cognitive impairment at scale: the IN LIFE experience
Authors: Astell A. J. , Panou M. , Touliou K. , Karavidopoulou Y. , Cabrera-Umpiérrez M. F. , Aldaz E. , Bizjak J. , Black B. , Buchholz M. , Mata J. Chamorro , Cossu-Ergecer F. , Debring S. , van-Weering M. Dekker , Ekström A. , Gams M. , Soler A. Garcia , Gradišek A. , Goljuf K. , Kaimakamis E. , Kaklanis N. , Kilintzis V. , Laakso K. , Maglaveras N. , Colomer J. B. Montalvá , Papageorgiou V. , Potter S. , Samuelsson C. , Smith S. K. , Tabak M. 
Published: December 2021

AbstractImplementing information and communications technology (ICT) at scale requires evaluation processes to capture the impact on users as well as the infrastructure into which it is being introduced. For older adults living with cognitive impairment, this requires evaluation that can accommodate different levels of cognitive impairment, alongside input from family and formal caregivers, plus stakeholder organisations. The European Horizon 2020 project INdependent LIving support Functions for the Elderly (IN LIFE) set out to integrate 17 technologies into a single digital platform for older people living with cognitive impairment plus their families, care providers and stakeholders. The IN LIFE evaluation took place across six national pilot sites to examine a number of variables including impact on the users, user acceptance of the individual services and the overall platform, plus the economic case for the IN LIFE platform. The results confirmed the interest and need among older adults, family caregivers, formal caregivers and stakeholders, for information and communications technology (ICT). Relative to the baseline, quality of life improved and cognition stabilised; however, there was an overall reluctance to pay for the platform. The findings provide insights into existing barriers and challenges for adoption of ICT for older people living with cognitive impairment.
How preferences shape the welfare and employment effects of trade
Authors: Egger Hartmut , Habermeyer Simone 
Published: December 2021

AbstractWe set up a trade model with two countries, two sectors, and one production factor, which features a home-market effect due to the existence of trade costs. We consider search frictions and firm-level wage bargaining in the sector producing differentiated goods and a perfectly competitive labor market in the sector producing a homogeneous good. Consumers have price-independent generalized-linear preferences over the two types of goods, covering homothetic and quasi-homothetic preferences as two limiting cases. Due to the specific functional forms of indirect utility, homothetic preferences lead to risk aversion, while quasi-homothetic preferences lead to risk neutrality in our model. We show that trade between two countries that differ in their population size leads to an expansion of the differentiated goods sector and a contraction of the homogeneous good sector in the larger economy. This induces the larger country to net-export differentiated goods at the cost of a higher economy-wide rate of unemployment in the open economy (with the effects reversed for the smaller country). The welfare effects of trade depend on the preference structure. Looking at the two limiting cases, we show that the larger country is likely to benefit from trade if preferences are homothetic, whereas losses from trade are possible if preferences are quasi-homothetic. The opposite is true in the smaller country. This reveals an important role of preferences for the welfare effects of trade in the presence of labor market imperfection, a result we further elaborate on by considering more general preferences as well as differences of countries in their per-capita income levels.
Assessment of regularization techniques in GNSS tropospheric tomography based on single- and dual-frequency observations
Authors: Adavi Zohreh , Weber Robert , Glaner Marcus Franz 
Published: December 2021

AbstractWater vapor is one of the most variable components in the earth's atmosphere and has a significant role in forming clouds, rain and snow, air pollution, and acid rain. Therefore, increasing the accuracy of estimated water vapor can lead to more accurate predictions of severe weather, upcoming storms, and natural hazards. In recent years, GNSS has turned out to be a valuable tool for remotely sensing the atmosphere. In this context, GNSS tomography evolved to an extremely promising technique to reconstruct the spatiotemporal structure of the troposphere. However, locating dual-frequency (DF) receivers with a spatial resolution of a few tens of kilometers sufficient for GNSS tomography is not economically feasible. Therefore, in this research, the feasibility of using single-frequency (SF) observations in GNSS tomography as an alternative approach has been investigated. The algebraic reconstruction technique (ART) and the total variation (TV) method are examined to reconstruct a regularized solution. The accuracy of the reconstructed water vapor distribution model using low-cost receivers is verified by radiosonde measurements in the area of the EPOSA (Echtzeit Positionierung Austria) GNSS network, which is mostly located in the east part of Austria for the period DoY 232–245, 2019. The results indicate that irrespective of the investigated ART and TV techniques, the quality of the reconstructed wet refractivity field is comparable for both SF and DF schemes. However, in the SF scheme the MAE with respect to the radiosonde measurements for ART + NWM and ART + TV can reach up to 10 ppm during noontime. Despite that, all statistical results demonstrate the degradation of the retrieved wet refractivity field of only 10–40% when applying the SF scheme in the presence of the initial guess.