bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended Injection Intervals of Gonadotropins by Intradermal Administration in IVF Treatment
Authors: Hsu Chao Chin , Hsu Isabel , Chang Hui Hua , Hsu Rosie , Dorjee Sonam 
Published: October 2021

AbstractContextGonadotropins can be administered every 5 days under intradermal injection in in vitro fertilization (IVF) treatment.ObjectiveTo explore the effectiveness of intradermal injection of recombinant human FSH (rhFSH) for women undergoing IVF.MethodsWomen who received their first IVF treatment enrolled in this prospective intervention in 2018. All women received a bolus of 900 IU rhFSH intradermally at day 2 of the treatment cycle followed by additional dosage of rhFSH at day 7 and/or day 10. The main outcome measures included the total dose of rhFSH and number of injections required, sequential serum FSH level detected, and number of mature oocytes retrieved.ResultsSeventy women completed the study. On average, 2.31 ± 0.73 injections and 1662 ± 397 IU of rhFSH were administered. While the baseline FSH level was 5.6 ± 2.2 IU/L, the serum concentrations of FSH after rhFSH administration were 35.3 ± 7.0 on the first day (24 hours) and 10.7 ± 3.7 IU/L on the fifth day (120 hours). A total of 10.5 ± 6.6 mature oocytes were retrieved, resulting in 7.3 ± 5.1 pronuclear embryos; 1.8 ± 0.6 embryos were transferred to the uterus. Our findings resulted in 72% fertilization, 91% cleavage, 31% implantation, and 36% live birth rates. Although fewer larger follicles were found, noninferiority results were noted in the mature oocytes retrieved, good embryos available, and clinical pregnancy rate compared with those received conventional daily subcutaneous rhFSH administration.ConclusionIntradermal administration of rhFSH, with a smaller dose of rhFSH and fewer injections, may achieve the goal of a cost-effective and more patient-friendly regimen.
Increased Prevalence of Fractures in Congenital Adrenal Hyperplasia: A Swedish Population-based National Cohort Study
Authors: Falhammar Henrik , Frisén Louise , Hirschberg Angelica Lindén , Nordenskjöld Agneta , Almqvist Catarina , Nordenström Anna 
Published: October 2021

Abstract

Context
Low bone mineral density has been reported in individuals with congenital adrenal hyperplasia (CAH), but the prevalence of fractures is unclear.

Objective
To study the prevalence of fractures in CAH.

Design, Setting, and Participants
Patients with CAH (n = 714, all 21-hydroxylase deficiency) were compared with controls matched for sex and year and place of birth (n = 71 400). Data were derived by linking National Population-Based Registers.

Main Outcome Measures
Number and type of fractures.

Results
Mean age was 29.8 ± 18.4 years. Individuals with CAH had more fractures compared to controls [23.5% vs 16.1%, odds ratio (OR) 1.61, 95% CI 1.35-1.91], and this was found in both sexes (females: 19.6% vs 13.3%, OR 1.57, 95% CI 1.23-2.02; males: 28.7% vs 19.6%, OR 1.65, 95% CI 1.29-2.12). Fractures were significantly increased in patients born before the introduction of neonatal screening but not in those born afterwards. Any major fracture associated with osteoporosis (spine, forearm, hip, or shoulder) was increased in all individuals with CAH (9.8% vs 7.5%, OR 1.34, 95% CI 1.05-1.72). The highest prevalence of fractures was seen in SV phenotype and I172N genotype while nonclassic phenotype and I2 splice genotype did not show increased prevalence. A transport accident as a car occupant and fall on the same level were more common in patients with CAH, both sexes, than in controls.

Conclusions
Patients with CAH had an increased prevalence of both any fracture and fractures associated with osteoporosis (both sexes) but not for patients neonatally screened. We conclude that fracture risk assessment and glucocorticoid optimization should be performed regularly.
Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study
Authors: Larsson Susanna C , Kar Siddhartha , Perry John R B , Carter Paul , Vithayathil Mathew , Mason Amy M , Easton Douglas F , Burgess Stephen 
Published: October 2021

AbstractContextThe causal role of endogenous estradiol in cancers other than breast and endometrial cancer remains unclear.ObjectiveThis Mendelian randomization study assessed the causal associations of endogenous 17β-estradiol (E2), the most potent estrogen, with cancer risk in women.MethodsAs primary genetic instrument, we used a genetic variant in the CYP19A1 gene that is strongly associated with serum E2 levels. Summary statistics genetic data for the association of the E2 variant with breast, endometrial, and ovarian cancer were obtained from large-scale consortia. We additionally estimated the associations of the E2 variant with any and 20 site-specific cancers in 198 825 women of European descent in UK Biobank. Odds ratios (OR) of cancer per 0.01 unit increase in log-transformed serum E2 levels in pmol/L were estimated using the Wald ratio.ResultsGenetic predisposition to higher serum E2 levels was associated with increased risk of estrogen receptor (ER)-positive breast cancer (OR 1.02; 95% CI, 1.01-1.03; P = 2.5 × 10−3), endometrial cancer overall (OR 1.09; 95% CI, 1.06-1.11; P = 7.3 × 10−13), and endometrial cancer of the endometrioid histology subtype (OR 1.10; 95% CI, 1.07-1.13; P = 2.1 × 10−11). There were suggestive associations with breast cancer overall (OR 1.01; 95% CI, 1.00-1.02; P = 0.02), ovarian cancer of the endometrioid subtype (OR 1.05; 95% CI, 1.01-1.10; P = 0.02), and stomach cancer (OR 1.12; 95% CI, 1.00-1.26; P = 0.05), but no significant association with other cancers.ConclusionThis study supports a role of E2 in the development of ER-positive breast cancer and endometrioid endometrial cancer but found no strong association with other cancers in women.
Efficacy of Differential Diagnosis of Thyroid Nodules by Shear Wave Elastography—the Stiffness Map
Authors: Yoo Myung Hi , Kim Hye Jeong , Choi In Ho , Park Suyeon , Yun Sumi , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil 
Published: October 2021

Abstract

Background
Fine needle aspiration is the gold standard for differential diagnosis of thyroid nodules; however, the malignancy rate for indeterminate cytology is 20% to 50%.

Objective
We evaluated the efficacy of shear wave elastography added to ultrasonography for differential diagnosis of thyroid nodules.

Methods
We retrospectively reviewed the medical records of 258 consecutive patients. Thyroid nodules were divided into 4 categories according to maximum elasticity (EMax) and nodule depth/width (D/W) ratio: Category 1 (EMax ≥ 42.6 kPa; D/W &lt; 0.9); Category 2 (EMax &lt; 42.6 kPa; D/W &lt; 0.9); Category 3 (EMax ≥ 42.6 kPa; D/W ≥ 0.9); and Category 4 (EMax &lt; 42.6 kPa; D/W ≥ 0.9). The EMax cutoff value was set using receiver operating characteristic (ROC) curve analysis to predict nodular hyperplasia (NH) vs follicular neoplasm (FN). Cutoff value for nodule D/W ratio was set using ROC curve analysis for malignancy.

Results
NH was the most prevalent pathology group in Category 1, FN in Category 2, and papillary thyroid carcinoma in Category 3. Category 3 demonstrated the highest rate of malignancy (81.8%) and had 55.4% sensitivity and 90% specificity for predicting malignancy. When assessing the benign pathology of NH in follicular patterned lesion, Category 1 demonstrated the highest NH prevalence of 88.9% (34/37) and had 73.9% sensitivity and 85.0% specificity.

Conclusion
The performance for malignancy was highest in Category 3 and predictive ability for benign pathology of NH in follicular lesion was highest in Category 1. The information of EMax and nodule D/W ratio was useful to predict the pathology of thyroid nodules.
Parental attitudes and intensification of borderline personality traits: the mediational role of self-control and identity integration
Authors: Kwapis Krzysztof , Prusak Jacek , Pohl Aleksandra , Krawczyk Agnieszka 
Published: October 2021

Cel pracyCelem artykułu jest ustalenie związku między postawami rodzicielskimi, samokontrolą, integracją tożsamości a cechami zaburzenia osobowości borderline (ZOB) w nieklinicznej próbie osób dorosłych, a także określenie roli samokontroli i integracji tożsamości jako predyktorów ZOB oraz jako potencjalnych mediatorów związku postaw rodzicielskich z cechami ZOB.MetodaBadania zostały przeprowadzone z udziałem 162 osób dorosłych pochodzących z populacji ogólnej, które wypełniały Kwestionariusz Retrospektywnej Oceny Postaw Rodziców (KPR-Roc) Plopy, podskalę Kwestionariusza Styl Życia 05/SK Trzebińskiej, podskalę „Integracja Tożsamości” Wielowymiarowego Kwestionariusza Samooceny MSEI autorstwa O’Brien i Epsteina w polskiej adaptacji Fecenec oraz Skalę Samokontroli (SCS) autorstwa Tangney i in. w adaptacji Kwapisa i Bartczuka.WynikiOtrzymane wyniki wskazują na istotne korelacje samokontroli i integracji tożsamości z postawami rodzicielskimi (z wyjątkiem postawy nadmiernie ochraniającej obojga rodziców), a także ujemne korelacje zarówno integracji tożsamości, jak i samokontroli z nasileniem cech ZOB. Zgodnie z wyniki uzyskanymi za pomocą modelowania strukturalnego, niekonsekwentna postawa matki i integracja tożsamości mają wyłącznie bezpośredni wpływ na cechy ZOB, natomiast nadmiernie wymagająca postawa matki i samokontrola wpływają na nasilenie tych cech jedynie pośrednio. Niekonsekwentna postawa ojca wywiera na cechy ZOB wpływ zarówno bezpośredni, jak i pośredni. Mediatorami związku nadmiernie wymagającej postawy matki i niekonsekwentnej postawy ojca z cechami ZOB są samokontrola i integracja tożsamości. Wpływ samokontroli na nasilenie cech ZOB jest zapośredniczony przez integrację tożsamości.WnioskiPostawy rodzicielskie matki i ojca mają związek z samokontrolą, integracją tożsamości i nasileniem cech ZOB. Samokontrola i integracja tożsamości są mediatorami wpływu wybranych postaw rodzicielskich na nasilenie cech ZOB.
The body image experiences of women working within the aesthetics sector: a thematic analysis of online survey and interview responses
Authors: Owen Alison , Taylor Jennifer 
Published: October 2021

Background: Body dissatisfaction can have negative implications on health and wellbeing. Aims: Women working within the aesthetics sector have been identified as being vulnerable to body dissatisfaction and disordered eating; however, research exploring this population is scarce. This research aimed to investigate the area further. Methods: Online surveys and interviews were used to explore the body image experiences of 41 women working in the aesthetics sector. Findings: Thematic analysis highlighted three themes: a feeling that looking ‘good’ was necessitated by their profession; ubiquitous and inevitable nature of appearance comparisons; and an appearance satisfaction dichotomy, with some reporting feeling satisfied and others dissatisfied. Conclusion: The body image experiences of women working in the aesthetic sector are mixed and can be complex. The implications of these findings and directions for future research are discussed.
Fungal skin infections
Authors: Perry Margaret 
Published: October 2021

Fungal infections of the skin continue to place a burden on healthcare services. Margaret Perry provides an overview of the most common conditions Fungal infections of the skin continue to place a burden on healthcare and are a significant issue globally in terms of their cost and impact on resources. Some are more difficult to treat than others and there is a wide variation in duration of treatment, depending on the site and severity. Many fungal infections share similarities in appearance with other skin conditions, which can sometimes make diagnosis difficult. This article details some of the most common conditions and aims to give nurses and non-medical prescribers an overview of evidence-based treatment and management as well as to increase confidence when managing some of these troublesome diseases.
Exposure, hazard, and vulnerability all contribute to Schistosoma haematobium re-infection in northern Senegal
Authors: Lund Andrea J. , Sokolow Susanne H. , Jones Isabel J. , Wood Chelsea L. , Ali Sofia , Chamberlin Andrew , Sy Alioune Badara , Sam M. Moustapha , Jouanard Nicolas , Schacht Anne-Marie , Senghor Simon , Fall Assane , Ndione Raphael , Riveau Gilles , De Leo Giulio A. , López-Carr David 
Published: October 2021

Background
Infectious disease risk is driven by three interrelated components: exposure, hazard, and vulnerability. For schistosomiasis, exposure occurs through contact with water, which is often tied to daily activities. Water contact, however, does not imply risk unless the environmental hazard of snails and parasites is also present in the water. By increasing reliance on hazardous activities and environments, socio-economic vulnerability can hinder reductions in exposure to a hazard. We aimed to quantify the contributions of exposure, hazard, and vulnerability to the presence and intensity of Schistosoma haematobium re-infection.

Methodology/Principal findings
In 13 villages along the Senegal River, we collected parasitological data from 821 school-aged children, survey data from 411 households where those children resided, and ecological data from all 24 village water access sites. We fit mixed-effects logistic and negative binomial regressions with indices of exposure, hazard, and vulnerability as explanatory variables of Schistosoma haematobium presence and intensity, respectively, controlling for demographic variables. Using multi-model inference to calculate the relative importance of each component of risk, we found that hazard (Ʃwi = 0.95) was the most important component of S. haematobium presence, followed by vulnerability (Ʃwi = 0.91). Exposure (Ʃwi = 1.00) was the most important component of S. haematobium intensity, followed by hazard (Ʃwi = 0.77). Model averaging quantified associations between each infection outcome and indices of exposure, hazard, and vulnerability, revealing a positive association between hazard and infection presence (OR = 1.49, 95% CI 1.12, 1.97), and a positive association between exposure and infection intensity (RR 2.59–3.86, depending on the category; all 95% CIs above 1)

Conclusions/Significance
Our findings underscore the linkages between social (exposure and vulnerability) and environmental (hazard) processes in the acquisition and accumulation of S. haematobium infection. This approach highlights the importance of implementing both social and environmental interventions to complement mass drug administration.
Review : Interaksi Alelopati dan Senyawa Alelokimia : Potensinya Sebagai Bioherbisida
Authors: Darmanti Sri 
Published: October 2021

Gulma merupakan salah satu kendala biotik utama dalam meningkatkan produksi berbagai tanaman budidaya. Pengendalian gulma dengan herbisida sintetis merupakan cara yang umum dilakukan karena mudah dan murah, tetapi cara ini tidak ramah lingkungan dan penggunaan jangka panjang dapat mengakibatkan resistensi pada gulma. Senyawa alelokimia secara alami digunakan tumbuhan untuk pertahanan terhadap ganguan lingkungan (interaksi alelopati), termasuk untuk menekan pertumbuhan tanaman pengganggu yang ada disekitarnya. Mekanisme penghambatan oleh alelokimia mirip dengan herbisida sintetik, sehingga alelopati berpotensi digunakan sebagai bioherbisida. Kelebihan bioherbisida dibanding herbisida sintetik adalah larut dalam air sehingga mudah diaplikasikan, memiliki banyak molekul kaya oksigen dan nitrogen, sedikit mengandung ”atom berat”, sedikit halogen dan tidak memiliki struktur cincin tidak alami, memiliki paruh waktu yang pendek sehingga tidak terjadi akumulasi senyawa di dalam tanah dan kecil kemungkinan menimbulkan dampak pada organisme non target.
Hubungan Kualitas Air dengan Pertumbuhan Semai Rhizophora mucronata Lamk. Pada Periode Pengamatan yang Berbeda
Authors: _ Solikhah , Hastuti Endah Dwi , Budihastuti Rini 
Published: October 2021

Pengelolaan kawasan tambak dapat dilihat dari peran mangrove dalam pengendalian kualitas lingkungan tambak. Pengelolaan ekosistem mangrove dapat dilakukan dengan polikultur atau wanamina (silvofishery). Penelitian ini bertujuan untuk mengetahui hubungan kualitas air (suhu, kekeruhan, salinitas, pH, dan DO) terhadap pertumbuhan semai Rhizophora mucronata Lamk. pada periode pengamatan yang berbeda di saluran tambak wanamina Semai mangrove sangat rentan terhadap perubahan lingkungan, sehingga kemampuan adaptasi terhadap lingkungan tumbuhnya menentukan keberhasilan pertumbuhan. Metode yang digunakan dalam penelitian ini yaitu Rancangan Acak Lengkap (RAL) dengan perlakuan periode pengamatan. Analisis data yang digunakan berupa analisis varians (ANOVA) satu faktor (periode pengamatan) dengan 6 perlakuan yaitu periode pengamatan I, II, III, IV, V , dan VI serta analisis regresi linear berganda untuk mengetahui hubungan kualitas lingkungan dengan pertumbuhan semai. Analisis data menunjukkan bahwa tingkat pertumbuhan daun rendah, pertumbuhan jumlah cabang belum ditemukan, diameter batang dan tinggi tanaman mengalami pertumbuhan. Periode pengamatan berpengaruh terhadap kualitas air. Kualitas air yg berpengaruh nyata yaitu suhu, kekeruhan dan salinitas. Kekeruhan dan suhu merupakan parameter kualitas air yang memiliki hubungan paling erat dengan pertumbuhan semai Rhizophora mucronata.
Efek Alelokimia Ekstrak Daun Babandotan( Ageratum Conyzoides L.) terhadap Kandungan Pigmen Fotosintetik dan Pertumbuhan Gulma Rumput Belulang (Eleusine Indica (L.) Gaertn)
Authors: Septiani Dian , Hastuti Endah Dwi , Darmanti Sri 
Published: October 2021

Rumput belulang (Eleusine indica (L.) Gaertn) merupakan gulma yang hidup di area pertanian. Pengendalian gulma dapat dilakukan dengan mengguanakan bioherbisida. Tanaman yang dapa dijadikan bioherbisida adalah tanaman yang mengandung alelokimia. Alelokimia adalah senyawa kimia yang dihasilkan tumbuhan dan apabila di keluarkan ke lingkungan mampu menghambat pertumbuhan tanaman disekitarnya Salah satu tanaman yang mengandung alelokimia adalah A. conyzoides. Penelitian ini bertujuan untuk mengetahui pengaruh alelokimia ekstrak daun A. conyzoides pada konsentrasi yang berbeda terhadap kandungan pigmen fotosintetik dan pertumbuhan gulma rumput belulang, serta mengetahui konsentrasi optimum yang dapat menghambat pertumbuhan rumput belulang. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktor tunggal yaitu konsentrasi ekstrak alelokimia A. conyzoides, masing – masing perlakuan dengan mengguanakan lima ulangan. Perlakuan dengan konsentrasi berbeda yaitu 0%, 5%, 10%, 15%. Parameter yang diamati yaitu kandungan klorofil a, klorofil b , klorofil total, karotenoid, bobot basah, bobot kering, tinggi tanaman, panjang akar, dan jumlah daun yang dianalisis dengan ANOVA dan dilanjutkan dengan Uji DMRT pada taraf kepercayaan 95%. Hasil penelitian ini menunjukkan bahwa semakin tinggi konsentrasi ekstrak memberikan pengaruh nyata terhadap penurunan kandungan klorofil a, klorofil b , klorofil total, karotenoid, bobot basah, bobot kering, tinggi tanaman, panjang akar, dan jumlah daun. Kata kunci : Rumput belulang, alelokimia, A. conyzoides, bioherbisida
Pengaruh Pemberian Ekstrak Air Biji Pepaya (Carica papaya L.) terhadap Stuktur Mikroanatomi Intestinum Tenue Mencit (Mus musculus L.) Betina
Authors: Hidayat Ibnu Thoriq , Sitasiwi Agung Janika , Mardiati Siti Muflichatun 
Published: October 2021

Ekstrak biji Pepaya (Carica papaya L.) mengandung saponin, alkaloid, flavonoid, dan tannin biasa digunakan sebagai bahan obat tradisional. Ekstrak ethanol biji papaya menunjukkan reaksi penghambatan pada kontraksi jejunum dan secara signifikan bersifat irreversible. Penelitian ini bertujuan untuk menguji pengaruh pemberian ekstrak air biji pepaya terhadap struktur mikroanatomi intestinum mencit (Mus musculus L.). Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4 perlakuan yaitu P0 (akuades), P1 (1,4 mg/0,5 ml), P2 (3,5 mg/0,5 ml) dan P3 (7 mg/0,5 ml). Perlakuan dilakukan secara oral selama 21 hari. Pemberian pakan secara ad libitum. Intestinum tenue diisolasi sepanjang 2 cm dari lambung sepanjang 1 cm kemudian di buat sediaan histologis dengan metode parafin dengan tebal sayatan 5 µm dan pewarnaan Hemaktosilin dan Eosin (H&E). Pengukuran panjang vili dan diameter intestinum tenue dilakukan pada 3 sayatan di setiap 3 sediaan histologis intestinum tenue. Data dianalisis dengan uji Anova, dilanjutkan dengan uji Duncan dengan taraf signifikansi 5%. Hasil analisis menunjukan paparan bahan uji tidak berpengaruh signifikan (p>0,05) terhadap panjang vili, dan bobot badan, tetapi menunjukan perbedaan yang signifikan (p,0.05) pada diameter intestinum. Penelitian ini dapat disimpulkan bahwa pemberian ekstrak air biji pepaya selama 21 hari tidak mempengaruhi struktur intestinum tenue mencit sehingga aman digunakan sebagai bahan obat.
A Study on the Acceptance Level of Rack Housing in Malaysia
Authors: Ho C.M. , Tan Q.N. , Shu Ing Doh , Omar J. , Al-Btoush Mohammed A.K.A. 
Published: October 2021

Rack housing is one type of modular construction system which is flexible and poses a higher degree of mobility. However, the idea of rack housing is relatively new and there is no clear indication of how far is the acceptance of Malaysian citizen to this idea. Therefore, this study aims to identify the acceptance level of Malaysian towards rack housing and also serve as the basic reference for both government and private sector for the adoption fo rack house in Malaysia. In this study, the acceptance level among Malaysian factors of consumer decision to purchase rack housing and also the perspective of Malaysian especially middle income group is determined. A set of questionnaire was made by Google form which contain question about the major factor of acceptance of Malaysian citizen on rack housing with total of 208 questionnaires. The data collected from different group of Malaysian was analyzed by using Average Index (AI). The degree of importance was determined by the rating scales. The result obtained is that the acceptance level to purchase rack housing based on location, comfortability and management factors. From the result, the respondances agree to accept rack housing to implement and construct in Malaysia.