bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gendered prisons, relationships and resettlement policies; three reasons for caution for imprisoned mothers
Authors: Booth Natalie 
Published: February 2021

Abstract
Drawing on the lived experiences and perceptions of five imprisoned mothers, this article critically explores female prisons, relationships and resettlement policies in England and Wales. The findings indicate how the infusing of gendered, informal social controls into penal interventions and penal policy has the potential to harm mothers. This is why three reasons for caution are proposed in relation to ‘structural obstacles’, ‘continued exposure to abuse’ and ‘ascribed reputations’. With these challenges, the mother’s aspirations for a crime- and drug-free future may be thwarted. Therefore, by showing the complex and dynamic set of circumstances that mothers in prison must navigate, more clearly, the need for a nuanced approach for working with women can be appreciated.
Low-pressure versus standard pressure laparoscopic colorectal surgery (PAROS trial): a phase III randomized controlled trial
Authors: Celarier S , Monziols S , Célérier B , Assenat V , Carles P , Napolitano G , Laclau-Lacrouts M , Rullier E , Ouattara A , Denost Q 
Published: February 2021

Abstract

Trial design
This is a phase III, double-blind, randomized, controlled trial.

Methods
In this trial, patients with laparoscopic colectomy were assigned to either low pressure (LP: 7 mmHg) or standard pressure (SP: 12 mmHg) at a ratio of 1 : 1. The aim of this trial was to assess the impact of low-pressure pneumoperitoneum during laparoscopic colectomy on postoperative recovery. The primary endpoint was the duration of hospital stay. The main secondary endpoints were postoperative pain, consumption of analgesics and postoperative morbidity.

Results
Some 138 patients were enrolled, of whom 11 were excluded and 127 were analysed: 62 with LP and 65 with SP. Duration of hospital stay (3 versus 4 days; P = 0.010), visual analog scale (0.5 versus 2.0; P = 0.008) and analgesic consumption (level II: 73 versus 88 per cent; P = 0.032; level III: 10 versus 23 per cent; P = 0.042) were lower with LP. Morbidity was not significantly different between the two groups (10 versus 17 per cent; P = 0.231).

Conclusion
Using low-pressure pneumoperitoneum in laparoscopic colonic resection improves postoperative recovery, shortening the duration of hospitalization and decreasing postoperative pain and analgesic consumption. This suggests that low pressure should become the standard of care for laparoscopic colectomy.

Trial registration
NCT03813797
Traumatic brain injury: a comparison of diffusion and volumetric magnetic resonance imaging measures
Authors: Bourke Niall J , Yanez Lopez Maria , Jenkins Peter O , De Simoni Sara , Cole James H , Lally Pete , Mallas Emma-Jane , Zhang Hui , Sharp David J 
Published: February 2021

Abstract
Cognitive impairment after traumatic brain injury remains hard to predict. This is partly because axonal injury, which is of fundamental importance, is difficult to measure clinically. Advances in MRI allow axonal injury to be detected after traumatic brain injury, but the most sensitive approach is unclear. Here, we compare the performance of diffusion tensor imaging, neurite orientation dispersion and density-imaging and volumetric measures of brain atrophy in the identification of white-matter abnormalities after traumatic brain injury. Thirty patients with moderate–severe traumatic brain injury in the chronic phase and 20 age-matched controls had T1-weighted and diffusion MRI. Neuropsychological tests of processing speed, executive functioning and memory were used to detect cognitive impairment. Extensive abnormalities in neurite density index and orientation dispersion index were observed, with distinct spatial patterns. Fractional anisotropy and mean diffusivity also indicated widespread abnormalities of white-matter structure. Neurite density index was significantly correlated with processing speed. Slower processing speed was also related to higher mean diffusivity in the corticospinal tracts. Lower white-matter volumes were seen after brain injury with greater effect sizes compared to diffusion metrics; however, volume was not sensitive to changes in cognitive performance. Volume was the most sensitive at detecting change between groups but was not specific for determining relationships with cognition. Abnormalities in fractional anisotropy and mean diffusivity were the most sensitive diffusion measures; however, neurite density index and orientation dispersion index may be more spatially specific. Lower neurite density index may be a useful metric for examining slower processing speed.
Depression in the Direct Pathway of the Dorsomedial Striatum Permits the Formation of Habitual Action
Authors: Yu Xiaoxuan , Chen Shijie , Shan Qiang 
Published: February 2021

Abstract
In order to achieve optimal outcomes in an ever-changing environment, humans and animals generally manage their action control via either goal-directed action or habitual action. These two action strategies are thought to be encoded in distinct parallel circuits in the dorsal striatum, specifically, the posterior dorsomedial striatum (DMS) and the dorsolateral striatum (DLS), respectively. The striatum is primarily composed of two subtypes of medium spiny neurons (MSNs): the direct-pathway striatonigral and the indirect-pathway striatopallidal MSNs. MSN-subtype-specific synaptic plasticity in the DMS and the DLS has been revealed to underlie goal-directed action and habitual action, respectively. However, whether any MSN-subtype-specific synaptic plasticity in the DMS is associated with habitual action, and if so, whether the synaptic plasticity affects the formation of habitual action, are not known. This study demonstrates that postsynaptic depression in the excitatory synapses of the direct-pathway striatonigral MSNs in the DMS is formed after habit learning. Moreover, chemogenetically rescuing this depression compromises the acquisition, but not the expression, of habitual action. These findings reveal that an MSN-subtype-specific synaptic plasticity in the DMS affects habitual action and suggest that plasticity in the DMS as well as in the DLS contributes to the formation of habitual action.
Kidney transplantation and COVID-19 renal and patient prognosis
Authors: Toapanta Néstor , Torres Irina B , Sellarés Joana , Chamoun Betty , Serón Daniel , Moreso Francesc 
Published: February 2021

AbstractCoronavirus disease 2019 (COVD-19) emerged as a pandemic in December 2019. Infection has spread quickly and renal transplant recipients receiving chronic immunosuppression have been considered a population at high risk of infection, complications and infection-related death. During this year a large amount of information from nationwide registries, multicentre and single-centre studies have been reported. The number of renal transplant patients diagnosed with COVID-19 was higher than in the general population, but the lower threshold for testing may have contributed to its better identification. Major complications such as acute kidney injury and acute respiratory distress syndrome were very frequent in renal transplant patients, with a high comorbidity burden, but further studies are needed to support that organ transplant recipients receiving chronic immunosuppression are more prone to develop these complications than the general population. Kidney transplant recipients experience a high mortality rate compared with the general population, especially during the very early post-transplant period. Despite the fact that some studies report more favourable outcomes in patients with a kidney transplant than in patients on the kidney waiting list, the higher mortality described in the very early post-transplant period would advise against performing a kidney transplant in areas where the spread of infection is high, especially in recipients &gt;60 years of age. Management of transplant recipients has been challenging for clinicians and strategies such as less use of lymphocyte-depleting agents for new transplants or anti-metabolite withdrawal and calcineurin inhibitor reduction for transplant patients with COVID-19 are not based on high-quality evidence.
Finding optimal assortativity configurations in directed networks
Authors: Uribe-Leon Cesar , Vasquez Juan C , Giraldo Marco A , Ricaurte German 
Published: February 2021

Abstract
The modelling of many complex systems is usually approached by directed networks where nodes and connections represent the elements of the system and their interactions respectively. The degree-assortativity, which is the tendency of nodes to link to nodes of similar degree, has four components in the digraphs case. In comparison with the undirected graph case, the degree-assortativity of digraphs has not been well studied despite the potential effects that it has to constraint or influence the structural and dynamical properties of a network. Thus, we have considered a random directed network and numerically trained the assortativity profiles of the four components (in–out; out–in; in–in; out–out) by applying degree-preserving rewiring, but we interestingly found that the widely used two-swap method is severely limited. In consequence, we used a much powerful and rather forgotten three-swap method capable to achieve all different assortativities configurations of the given initial random graphs. Secondly, we characterized the obtained networks in relation to other common structural properties such as path length and algebraic connectivity. Finally, by simulating and analysing a dynamical process on the network, we have found that certain profiles cause the network to exhibit enhanced sensitivity to small perturbations without losing their stability.
Real-World Long-Term Remission Maintenance for 10 Years With Thiopurines in Ulcerative Colitis
Authors: Matsumoto Satohiro , Mashima Hirosato 
Published: February 2021

AbstractBackgroundTo evaluate the therapeutic outcomes and long-term prognosis of patients receiving remission maintenance therapy using thiopurines for ulcerative colitis (UC).MethodsOf 193 biologic-naive patients with UC who began thiopurine therapy at our hospital between 2000 and 2019, 161 patients were included after the exclusion of 32 patients who were intolerant to thiopurines and discontinued the drugs within 3 months. Short- and long-term clinical outcomes were retrospectively analyzed. Subsequently, the patients were divided into 2 groups (exacerbation and nonexacerbation groups) and clinical outcomes were analyzed and compared. Multivariate analysis was performed to identify risk factors for UC exacerbation. Finally, adverse events observed in 193 patients were examined.ResultsClinical remission rates at 2 months, 6 months, and 1 year after the start of thiopurine therapy were 50.0%, 58.0%, and 63.9%, respectively. At 1, 2, 5, and 10 years, the cumulative event-free rates were 77.6%, 60.8%, 48.5%, and 42.2%, respectively; the cumulative UC exacerbation rates were 17.0%, 32.5%, 42.2%, and 43.7%, respectively; and the cumulative colectomy rates were 0.6%, 1.3%, 8.5%, and 10.7%, respectively. Prior use of steroids (dose ≥40 mg/d) was a significant risk factor for UC exacerbation during remission maintenance therapy with thiopurines (hazard ratio, 2.26; 95% confidence interval, 1.18–4.34; P = 0.014). Adverse reactions occurred in 42 patients (21.8%; 46 events). Concurrent diseases were observed in 18 patients (9.3%).ConclusionsThiopurines were effective for long-term maintenance of remission in steroid-dependent/refractory UC. Their effect weakened in only a few patients continuously treated with them for 4 years or longer.
Case report regarding the evolution of electrocardiographic and echocardiographic features in cardiac amyloidosis
Authors: Vervaat Fabienne E , Bouwmeester Sjoerd , Vlaar Pieter-Jan 
Published: February 2021

Abstract

Background
Cardiac amyloidosis is an important cause for heart failure with preserved ejection fraction. It is often under diagnosed due to the fact that clinicians do not always recognize the specific diagnostic findings associated with this disease, also leading to the wrong diagnosis. When left untreated further irreversible organ dysfunction occurs, with high morbidity and mortality rates.

Case summary
A 71-year-old patient presented with progressive exertional dyspnoea and angina pectoris at the outpatient clinic. Medical history noted a percutaneous coronary intervention of the right coronary artery due to stable angina pectoris. The electrocardiogram showed low voltage in the limb leads and pseudo-infarct pattern in the precordial leads. Echocardiographic findings included left and right ventricular hypertrophy, decreased left ventricular systolic function, restrictive diastolic function, and ‘relative’ apical sparing of the left ventricle. This led to the suspicion of cardiac amyloidosis, which was confirmed with a positive bone scintigraphy using 99mTechnecium-DPD and the absence of monoclonal proteins. Treatment with Tafamidis was initiated.

Discussion
Electrocardiographic findings suggestive of cardiac amyloidosis are low voltage in the limb leads and/or a pseudo-infarct pattern in the precordial leads. Important echocardiographic findings are left and right ventricular hypertrophy, restrictive diastolic function, ‘relative’ apical sparing of the left ventricle and impaired left atrial strain. The next step in confirming the diagnosis is 99mTechnecium PYP/DPD/HMDP bone scintigraphy and testing for monoclonal proteins. The diagnosis ATTR amyloidosis is confirmed by the combination of positive bone scintigraphy (Perugini Grade 2 or 3) and the absence of monoclonal proteins, without the necessity of performing an endomyocardial biopsy.
Thirty Years after the Fall of the Berlin Wall—Do East and West Germans Still Differ in Their Attitudes to Female Employment and the Division of Housework?
Authors: Zoch Gundula 
Published: February 2021

Abstract
Previous cross-sectional studies highlight persistent East–West differences in gender ideologies after German reunification. This study examines the extent to which gender ideologies in the East and West have converged and whether differences are still relevant for younger cohorts who experienced childhood around the time of reunification, or after 1989. Using data from the German Family Panel pairfam (2008–2019) and differences in regime-specific socialization for three cohorts born before and after reunification, results reveal that different dimensions of gender ideologies have only partly converged 30 years after reunification. Attitudes towards housework and female employment converged particularly, yet, in all cohorts, views on maternal employment remain substantially different between East and West. Observed convergence occurred only partly due to contrasting trends of modernization in West Germany and re-traditionalization in East Germany. Moreover, the results highlight smaller attitude changes with increasing age, particularly for the younger cohorts, contributing to further variations in East–West differences. Overall, the findings confirm the existence of long-lasting ideology differences due to regime-specific socialization, and a persistently altered composition of society in East and West Germany. At the same time, they point towards slow convergence among younger cohorts due to a more similar institutional and socialization context following reunification.
A historical cohort study of glycemic control in patients with concurrent type 2 diabetes and substance use disorder treated in a primary care setting
Authors: DeYoung Oktawia A , Boehmer Kaci , Hung Denise , McAdam-Marx Carrie 
Published: February 2021

Abstract

Background
Substance use disorder (SUD) is a known barrier to patient-self-management, which can hinder efforts to achieve treatment goals in type 2 diabetes (T2D) when the conditions coexist.

Objective
Identify the association between SUD and glycemic control in patients with T2D treated in a primary care setting.

Methods
This retrospective cohort study included patients with T2D treated by providers at family medicine clinics at an academic medical center and its affiliated regional sites from January 2014 to October 2019. Study index date was the first A1c recorded when T2D and SUD diagnoses had both been documented in the medical record. Glycemic control, measured by hemoglobin A1c (A1c), was identified at baseline and over a 12-month follow-up period and was compared between SUD and non-SUD patients.

Results
Of 9568 included patients with T2D, 468 (4.9%) had a SUD diagnosis. In 237 SUD and 4334 non-SUD patients with A1c data, mean (SD) baseline A1c was 8.2% (2.5) and 7.9% (2.1), respectively (P = 0.043). A1c reduction was statistically greater in SUD patients than non-SUD patients (−0.31% versus −0.06%, respectively; P = 0.015), although the clinical significance is modest. In a multivariable linear regression analysis, follow-up A1c was lower in the SUD versus non-SUD patients (coefficient −0.184, 95% CI −0.358, −0.010; P = 0.038).

Conclusions
Patients with T2D and SUD had higher baseline A1c but this difference was minimized over a 12-month follow-up period. Additional research is warranted to determine long-term glycemic control and barriers to attaining and maintaining glycemic control in patients with T2D and SUD.
metaXplor: an interactive viral and microbial metagenomic data manager
Authors: Sempéré Guilhem , Pétel Adrien , Abbé Magsen , Lefeuvre Pierre , Roumagnac Philippe , Mahé Frédéric , Baurens Gaël , Filloux Denis 
Published: February 2021

Abstract

Background
Efficiently managing large, heterogeneous data in a structured yet flexible way is a challenge to research laboratories working with genomic data. Specifically regarding both shotgun- and metabarcoding-based metagenomics, while online reference databases and user-friendly tools exist for running various types of analyses (e.g., Qiime, Mothur, Megan, IMG/VR, Anvi'o, Qiita, MetaVir), scientists lack comprehensive software for easily building scalable, searchable, online data repositories on which they can rely during their ongoing research.

Results
metaXplor is a scalable, distributable, fully web-interfaced application for managing, sharing, and exploring metagenomic data. Being based on a flexible NoSQL data model, it has few constraints regarding dataset contents and thus proves useful for handling outputs from both shotgun and metabarcoding techniques. By supporting incremental data feeding and providing means to combine filters on all imported fields, it allows for exhaustive content browsing, as well as rapid narrowing to find specific records. The application also features various interactive data visualization tools, ways to query contents by BLASTing external sequences, and an integrated pipeline to enrich assignments with phylogenetic placements. The project home page provides the URL of a live instance allowing users to test the system on public data.

Conclusion
metaXplor allows efficient management and exploration of metagenomic data. Its availability as a set of Docker containers, making it easy to deploy on academic servers, on the cloud, or even on personal computers, will facilitate its adoption.
Linking elastic and electrical properties of rocks using cross-property DEM
Authors: Cilli P A , Chapman M 
Published: February 2021

SUMMARY
Combining electrical and elastic measurements can be instrumental in lowering the uncertainty of subsurface characterization. Many commonly used rock physics relations for joint electrical–elastic properties are at least partly empirical and often rely on the estimation of porosity as an intermediate step. We combine differential effective medium schemes that relate, respectively, elastic and electrical properties to porosity and pore shape. The resulting expressions are independent of porosity, depending only on pore aspect ratio. Analysis of published joint electrical–elastic data shows that a single aspect ratio model performs well for clean sandstones, allowing us to model Vp/Vs ratios as a function of resistivity. Clay-bearing sandstones are more complex, but our modelling can still identify the correct trends. We speculate about the potential to extend our approach to produce additional cross-property relations.
Sensitivity kernels for static and dynamic tomography of scattering and absorbing media with elastic waves: a probabilistic approach
Authors: Zhang Tuo , Sens-Schönfelder Christoph , Margerin Ludovic 
Published: February 2021

SUMMARYScattered seismic coda waves are frequently used to characterize small scale medium heterogeneities, intrinsic attenuation or temporal changes of wave velocity. Spatial variability of these properties raises questions about the spatial sensitivity of seismic coda waves. Especially the continuous monitoring of medium perturbations using ambient seismic noise led to a demand for approaches to image perturbations observed with coda waves. An efficient approach to localize spatial and temporal variations of medium properties is to invert the observations from different source–receiver combinations and different lapse times in the coda for the location of the perturbations. For such an inversion, it is key to calculate the coda-wave sensitivity kernels which describe the connection between observations and the perturbation. Most discussions of sensitivity kernels use the acoustic approximation in a spatially uniform medium and often assume wave propagation in the diffusion regime. We model 2-D multiple non-isotropic scattering in a random elastic medium with spatially variable heterogeneity and attenuation using the radiative transfer equations which we solve with the Monte Carlo method. Recording of the specific energy density of the wavefield that contains the complete information about the energy density at a given position, time and propagation direction allows us to calculate sensitivity kernels according to rigorous theoretical derivations. The practical calculation of the kernels involves the solution of the adjoint radiative transport equations. We investigate sensitivity kernels that describe the relationships between changes of the model in P- and S-wave velocity, P- and S-wave attenuation and the strength of fluctuation on the one hand and seismogram envelope, traveltime changes and waveform decorrelation as observables on the other hand. These sensitivity kernels reflect the effect of the spatial variations of medium properties on the wavefield and constitute the first step in the development of a tomographic inversion approach for the distribution of small-scale heterogeneity based on scattered waves.