bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced room‐temperature magnetoelectric coupling effects in c‐axis oriented polycrystalline BaSrCo2‐xMgxFe11AlO22
Authors: Chen Xing‐Han , Zhai Kun , Qian Guo‐Yu , Fu Qing‐Shan , Chakrabarti Chiranjib , Li Cang‐Long , Yin Hong‐Xia , Qiu Yang , Tian Zhao‐Ming , Yuan Song‐Liu 
Published: February 2021

AbstractThe influence of applied magnetic field during annealing process as well as of Mg doping on the room‐temperature magnetoelectric coupling effects in BaSrCo2‐xMgxFe11AlO22 are experimentally studied through the magnetization, magnetodielectric, and magnetoelectric current measurements. Hexaferrite samples of Co2Y were found to be highly oriented by an applied magnetic field (Ho) during the annealing process, leading to an enhancement of the room‐temperature magnetoelectric coupling effects. Although the substitution of nonmagnetic Mg ions in Co sites tends to reduce the ferromagnetism at macroscopic scale, a proper amount of Mg doping content facilitates the superexchange interaction between the adjacent magnetic blocks; meanwhile modulates the magnetic anisotropy in the samples. An appropriate adjustment of the competition between the anisotropy and the superexchange could enhance the magnetoelectric coupling at room temperature, which can be confirmed by the magnetic‐field‐induced dielectric constant and current density study.
Antiepileptic drugs, occurrence of seizures and effect of co‐administration of potential seizure threshold‐lowering psychotropic drugs in adults with intellectual disability who have epilepsy
Authors: Monaghan Rosemary , O’Dwyer Máire , Luus Retha , Mulryan Niamh , McCallion Philip , McCarron Mary , Henman Martin C. 
Published: February 2021

AbstractBackgroundThis study explored antiepileptic drug use, frequency of seizures, and the effect of psychotropic drugs with the potential to lower the seizure threshold in persons diagnosed with epilepsy and intellectual disability.MethodsData for this study were drawn from Wave 3 of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS‐TILDA). Psychotropic drugs were categorised for potential seizure threshold‐lowering risk (low, moderate, high). Binary logistic regression was performed to identify factors associated with seizure frequency.ResultsEpilepsy prevalence was 35.8% (n = 196), of which 57.7% reported a mental health condition. Participants with seizure data classified as taking at least one moderate‐/high‐risk medication were significantly less likely to experience a seizure compared to participants taking no potential seizure threshold‐lowering medication.ConclusionsPsychotropic drugs recommended to be avoided or used with caution did not provoke increased seizure frequency in this cohort.
Oral bisphosphonates for osteoporosis in adult males with intellectual disabilities
Authors: May Philip B. , Parker Frank 
Published: February 2021

AbstractIntroductionOral bisphosphonates are first‐line agents for treating osteoporosis in men, but there are no studies regarding efficacy of oral bisphosphonates for treatment of osteoporosis in ambulatory male adults with intellectual disability.MethodsNine adult males with intellectual disability and increased fracture risk had been treated with weekly or monthly oral bisphosphonates, vitamin D and calcium for 1–3 years. Post‐treatment bone mineral density (BMD), serum 25(OH)D, parathyroid hormone and C‐telopeptide of type I collagen were then determined for the first time.ResultsWeekly or monthly oral bisphosphonates were well tolerated and led to significant increases in BMD in all 9 individuals. Serum 25(OH)D level enhanced the “pecent increase of BMD” that occurred in response to bisphosphonate treatment (p < .05).ConclusionsWeekly or monthly oral bisphosphonates are well tolerated by ambulatory adult males with ID and are effective in increasing BMD. Higher serum levels of vitamin D appear to improve the efficacy of bisphosphonates and therefore reduce fracture risk in adult males with intellectual disability.
The Dark and Bright Sides of Complexity: A Dual Perspective on Supply Network Resilience
Authors: Wiedmer Robert , Rogers Zachary S. , Polyviou Mikaella , Mena Carlos , Chae Sangho 
Published: February 2021

AbstractSupply networks are regularly affected by events that trigger supply disruptions, entailing severe consequences for firms and their supply networks. Hence, the ability of firms to withstand and recover from disruptions (i.e., their resilience) is vital to their long‐term survival. Prior research suggests that the complexity of a firm’s supply network is critical in determining its resilience to disruptions, but tensions arise when delineating the precise nature of the relationship between supply network complexity and resilience. In this research, we investigate whether and how three facets of supply network complexity—supply complexity (nodes in the network), logistics complexity (arcs in the network), and product complexity (contents moving through the network)—influence a firm’s ability to resist and recover from disruptions. We empirically investigate this relationship in the context of automotive sector shipments from Japan to the United States before, during, and after the 2011 Japanese Earthquake and Tsunami, using the difference‐in‐differences technique. Results indicate that the relationship between supply network complexity and resilience is multifaceted; some aspects of supply network complexity intensify disruption impact, whereas others enhance disruption recovery.
Cryoballoon atrial fibrillation ablation: Single‐center safety and efficacy data using a novel cryoballoon technology compared to a historical balloon platform
Authors: Kochi Adriano N. , Moltrasio Massimo , Tundo Fabrizio , Riva Stefania , Ascione Ciro , Dessanai Maria A. , Pizzamiglio Francesca , Vettor Giulia , Cellucci Selene , Gasperetti Alessio , Tondo Claudio , Fassini Gaetano 
Published: February 2021

AbstractIntroductionCatheter ablation is superior to drugs regarding atrial fibrillation (AF) recurrence, symptoms improvement, and mortality reduction in heart failure. POLARx™ is a novel cryoballoon, with technical improvements seeking to improve outcomes. So far, its clinical evidence is restricted to a case report.MethodsTo compare the POLARx™ cryoballoon procedural safety and efficacy to the already established Arctic Front Advance PRO™ (AFAP) in a single‐center cohort study, consecutive patients undergoing AF cryoablation with the POLARx™ were enrolled. Data were prospectively gathered. POLARx™ patients were compared with a historical cohort of patients submitted to AF cryoablation with the AFAP.ResultsSeventy patients were analyzed, 20 in POLARx™, and 50 in the AFAP group. They all underwent first‐time pulmonary vein isolation, 77% were male, 94% had paroxysmal AF, median age was 62.5 years, median CHA2DS2‐VASc 1, left‐atrium size 34 ml/m², and 65% were receiving anticoagulation. The primary end‐point, all pulmonary veins isolation, was 100% in both groups. The complication rate was similar (0% POLARx™ vs. 5.7% AFAP, p = .39). The median total procedural time was longer in the POLARx™ group (90 min vs. 60 min, p < .001), but the overall time‐to‐isolation (TTI; 44.8 s vs. 39 s, p = .253) and ablation time (15 min vs. 13.7 min, p = .122) was similar between POLARx™ and AFAP groups, respectively. Despite equal TTI, the POLARx™ had a lower minimal temperature reached (−57°C vs −47°C, p < .001).ConclusionThe novel POLARx™ cryoballoon had similar efficacy and safety compared with the AFAP. It was also associated with longer procedural times, similar TTI, and lower minimum temperature reached.
Quantitative evaluation of white matter hyperintensities in patients with heart failure using an innovative magnetic resonance image analysis method: Association with disrupted circadian blood pressure variation
Authors: Komori Takahiro , Hoshide Satoshi , Tabei Ken‐ichi , Tomimoto Hidekazu , Kario Kazuomi 
Published: February 2021

AbstractWhite matter hyperintensities (WMHs) are risk factors for future cognitive impairment and are associated with an abnormal circadian blood pressure (BP) rhythm in patients with hypertension. However, whether this association exists in patients with heart failure (HF) is unclear. We performed a cross‐sectional study of hospitalized patients with HF who underwent ambulatory BP monitoring and brain magnetic resonance imaging (MRI). A non‐dipper BP pattern was defined as a < 10% nocturnal BP decline. WMHs on brain MRI scans were quantitated using a novel image analysis software (FUSION: FUsed Software for Imaging Of Nervous system). We enrolled 28 hospitalized patients with HF (age: 70.0 ± 9.8 years, 64.3% men). In the brain MRI analysis, the non‐dipper group had higher WMH volume (18.9 ± 19.8 vs. 7.7 ± 8.3 mL, P = .047) and percentage of WMH/total brain volume (1.31 ± 1.28% vs. 0.55 ± 0.58%, P = .04) than the dipper group. In conclusion, using the newly developed MRI analysis software, we successfully quantitatively measured the volume of WMHs and found that the WMH volume increased 2.4 times in patients with a non‐dipper pattern of nocturnal BP compared with those with a normal dipper pattern.
Kinase GSK3β functions as a suppressor in colorectal carcinoma through the FTO‐mediated MZF1/c‐Myc axis
Authors: Zhang Zeyan , Gao Qianfu , Wang Shanchao 
Published: February 2021

AbstractColorectal carcinoma (CRC) poses heavy burden to human health and has an increasing incidence. Currently, the existing biomarkers for CRC bring about restrained clinical benefits. GSK3β is reported to be a novel therapeutic target for this disease but with undefined molecular mechanisms. Thus, we aimed to investigate the regulatory effect of GSK3β on CRC progression via FTO/MZF1/c‐Myc axis. Firstly, the expression patterns of GSK3β, FTO, MZF1 and c‐Myc were determined after sample collection. Lowly expressed GSK3β but highly expressed FTO, MZF1 and c‐Myc were found in CRC. After transfection of different overexpressed and interference plasmids, the underlying mechanisms concerning GSK3β in CRC cell functions were analysed. Additionally, the effect of GSK3β on FTO protein stability was assessed followed by detection of MZF1 m6A modification and MZF1‐FTO interaction. Mechanistically, GSK3β mediated ubiquitination of demethylase FTO to reduce FTO expression. Besides, GSK3β inhibited MZF1 expression by mediating FTO‐regulated m6A modification of MZF1 and then decreased the proto‐oncogene c‐Myc expression, thus hampering CRC cell proliferation. We also carried out in vivo experiment to verify the regulatory effect of GSK3β on CRC via FTO‐mediated MZF1/c‐Myc axis. It was found that GSK3β inhibited CRC growth in vivo which was reversed by overexpressing c‐Myc. Taken together, our findings indicate that GSK3β suppresses the progression of CRC through FTO‐regulated MZF1/c‐Myc axis, shedding light onto a new possible pathway by which GSK3β regulates CRC.
Convergent Validity of Suffering and Quality of Life as Measured by The Hidradenitis Suppurativa Quality of Life
Authors: Kursawe Larsen C. , Kjærsgaard Andersen R. , Kirby J. S. , Tan J. , Saunte D. M. L. , Jemec G. B. E. 
Published: February 2021

AbstractBackgroundHidradenitis suppurativa (HS) is a painful chronic, recurrent inflammatory skin disease with great impact on health‐related quality of life (HRQOL). Recently, Hidradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC) established HRQOL as a core domain set for HS clinical trials and developed the Hidradenitis Suppurativa Quality of Life (HiSQOL) as a validated outcome measurement instrument.ObjectivesTo provide further convergent validity of HiSQOL by comparing it to Dermatology Life Quality Index (DLQI) and Pictorial Representation of Illness and Self Measure‐Revised 2 (PRISM‐R2).MethodsIn this cross‐sectional study, 103 participants completed HiSQOL, PRISM‐R2 and DLQI. PRISM‐R2 is an instrument designed to measure suffering and reports the two measures, Illness Perception Measure (IPM) and Self‐Illness Separation (SIS). Correlation analyses were performed including a sub‐analysis for a subgroup of patients with high scores in the HS‐specific domains of HiSQOL.ResultsA very strong correlation was found between HiSQOL and DLQI (ρ = 0.93, P < 2.2 × 10−16, (95% CI: 0.89;0.95)), and moderately strong correlations were found between HiSQOL and SIS (ρ = −0.73, P < 2.2 × 10−16, (95% CI: −0.81; −0.62)) and DLQI and SIS (ρ = −0.70, P < 2.2 × 10−16, (95% CI: −0.79; −0.59)). IPM was positively associated with HiSQOL and DLQI and negatively with SIS.ConclusionsHiSQOL is a valid measure of quality of life for HS patients, and we suggest that HiSQOL can be used as a measure of suffering as well.
Quality of systematic reviews in HIV: The case of clinical outcomes associated with patient medication adherence
Authors: Lake Joanita , Lawrence Kendra A. , Martinez Alonso Elena , Gonzales Valerie , LaFleur Joanne 
Published: February 2021

AbstractAimUse of systematic reviews (SRs) as first‐level evidence for guideline recommendations hinges on review quality. In particular, US guidelines for adherence‐related recommendations in the treatment of human immunodeficiency virus (HIV) are not based on available SRs of adherence‐outcome relationships; it is unclear why. No published studies report on the quality of SRs on HIV adherence and outcomes, which may be driving the lack of use. We describe the quality of this body of literature.MethodsLiterature searches were conducted in Ovid MEDLINE, EMBASE, CINAHL, PubMed Central, the Cochrane Library, Science Citation Index, Web of Science, ScIELO Citation Index, and Ovid Emcare. Screening and quality assessments were performed in duplicate using AMSTAR 2. Funding sources and impact factors of publishing journals were also extracted, and correlations between quality rankings and numbers of critical weaknesses versus impact factors were assessed using Spearman's rank correlation coefficient.ResultsNine SRs of 1141 records met eligibility criteria. Overall confidence in the results was critically low for most (78%) SRs. Underperformance was found across all AMSTAR 2 domains. Impact factor (a surrogate or journal reputation) did not correlate with quality.ConclusionsSRs do not necessarily comprise top‐level evidence despite the availability of quality appraisal tools and reporting guidance, which could explain the lack of SR evidence in US HIV medication adherence‐related guideline recommendations. All parties to evidence synthesis publication should require quality assessment of studies.
Long‐term automatic trap data reveal factors affecting diurnal flight patterns of the Mediterranean Fruit fly
Authors: Goldshtein Eitan , Gazit Yoav , Hetzroni Amots , Timar Doron , Rosenfeld Lavi , Grinshpon Yossef , Cohen Yafit 
Published: February 2021

AbstractMediterranean Fruit Fly (medfly), Ceratitis capitata (Wiedemann), is considered to be one of the most destructive fruit insect pests throughout the world. In recent years, the temporal dynamics of the medfly have been extensively studied by season, and, to a lesser extent, on a daily basis. We exploited, for the first time, a sequential automatic medfly male trapping system, in combination with climate data, to characterize diel flight patterns of male medflies trapped. The process was carried out in four commercial citrus fields over three growing seasons. Results showed that throughout the year, medfly flight activity began 4–6 hr after sunrise and peaked up to 2 to 3 hr before sunset. Generalized additive models (GAM) of the 934 days sampled revealed that in the fall, the diurnal flight activity was unimodal, that is, it began increasing at noon, peaking in the afternoon. By contrast, in the spring and summer, the diurnal flight activity exhibited a bimodal pattern, decreasing at midday. GAMs also revealed that hour after sunrise and temperature influenced medfly captures, with the former the more dominant factor. Thus, photophase significantly impacted the medfly's diurnal flight activity in each season. This study demonstrated that automatic traps that timestamp each capture are a primary research tool in insect flight activity studies that contributes to understanding diurnal insect activity within the growing season.
Association of Parent–child Experiences with Insecure Attachment in Adulthood: A Systematic Review and Meta‐analysis
Authors: Kim Sin‐Hyang , Baek Minja , Park Sihyun 
Published: February 2021

AbstractThis study reviewed and synthesized existing research to examine the association of parent–child experiences in childhood with two types of adult insecure attachments styles: anxiety‐related attachment (ANA) and avoidance‐related attachment (AVA). Correlates of adult insecure attachment styles were systematically reviewed and quantitatively synthesized using meta‐analytic methods. Overall, 213 and 177 correlates with ANA and AVA were identified from 56 studies, with these factors further categorized into four thematic domains: perceived attachment with parents, perceived parenting style, perceived relationship with parents, and recalled childhood adversity. Children's attachment patterns with their parents were strongly associated with their pattern of adult attachment. Codependent relationships with parents, childhood neglect, and childhood psychological abuse were also significantly associated with both ANA and AVA. Authoritarian and authoritative parenting styles showed the strongest positive and negative associations with ANA and AVA, respectively. Our findings revealed the importance of early parenting for children's lifelong health and developmental outcomes.
Positioning of Bristol Stool Form Scale type 3 in constipation treatment satisfaction: A multicenter study in Japan
Authors: Yamada Eiji , Tsunoda Seishi , Mimura Masumi , Akizuki Masashi , Miyazawa Yoichiro , Yamazaki Toshihiro , Nagano Yasuhiko , Murakami Reiko , Kitahara Takashi , Wakasugi Junichi , Ozawa Yukihiro , Komatsu Tatsuji , Inamori Masahiko , Nagai Kazuki , Nakajima Atsushi 
Published: February 2021

AbstractBackground and AimMany patients are not satisfied with chronic constipation (CC) treatments. The aim of this study was to identify factors linked to CC treatment satisfaction or dissatisfaction.MethodsOur study population included patients who received CC treatment at a clinic or hospital. CC was diagnosed by a physician based on the patient's complaint. Treatment satisfaction was evaluated using the 28th question of the Patient Assessment of Constipation Quality of Life questionnaire.ResultsWe conducted this study at 28 facilities. We included 167 patients (mean age 66.7 ± 15.2 years, male:female ratio is 1:3.07). Sixty‐eight (40.7%) of patients were satisfied with their constipation treatment. Treatment dissatisfaction of CC was significantly associated with frequency of bowel movement <3/week (odds ratio [OR] = 0.376, 95% confidence interval [CI]: 0.156–0.904, P = 0.029) or Bristol Stool Form Scale (BSFS) type 3 (OR = 0.401, 95% CI: 0.170–0.946, P = 0.037).ConclusionsOur study showed that CC patients with BSFS type3 were not satisfied with constipation treatment. In general, BSFS types 3–5 are defined as normal stools. Therefore, BSFS type 3 may be set as a treatment goal even though the patient is not satisfied. The pathophysiology of CC differs by region and patient background. Therefore, parameters used to define successful treatment will be different by patient or region. We should reconsider the positioning of BSFS type 3 to improve treatment satisfaction for CC.
Longitudinal Impact of Frailty States and Sleep Duration on Subsequent Depressive Symptoms of Older Adults
Authors: Liu Huiying , Li Danyu , Zhao Xinyi , Fang Boye , Zhang Quan , Li Tingyu 
Published: February 2021

ObjectivesTo determine the effects of baseline and changes in frailty states on subsequent depressive symptoms, and whether sleep duration would modify these effects.DesignProspective, cohort study.SettingThe 2011 baseline and 2013 follow‐up waves of the China Health and Retirement Longitudinal Study (CHARLS).ParticipantsCommunity‐dwelling old adults who were aged 60 or above at baseline and participated in the 2011 and 2013 waves of the CHARLS (N = 5,026).MeasurementsFrailty was measured using the physical frailty phenotype (PFP) scale. Levels of depressive symptoms were measured by the 10‐item Center for Epidemiologic Studies Depression Scale (CES‐D). Using the generalized estimating equations (GEE), the effects of baseline and transitions in frailty states were examined on subsequent depressive symptoms, adjusting for a range of confounding variables.ResultsBaseline prefrail (b = 0.97, P < .05) and frail states (b = 0.35, P < .05) were associated with higher subsequent level of depressive symptoms 2 years later. Within individuals who were robust at baseline, transitioning into prefrail/frail (b = 3.04, P < .001) was associated with a higher subsequent level of depressive symptoms, and this association was accelerated by short sleep duration. Within individuals who were prefrail at baseline, transitioning into frail (b = 1.76, P < .001) was associated with higher subsequent levels of depressive symptoms, and this association was stronger among those who reported short sleep duration.ConclusionBaseline and transitions in frailty states were significantly related with higher subsequent levels of subsequent depressive symptoms. Short sleep duration significantly moderated the effects of baseline or transitions of frailty on subsequent depressive symptoms. Targeted interventions could be implemented to improve sleep quality for prefrail and frail older adults.
An update on the function and regulation of methylerythritol phosphate and mevalonate pathways and their evolutionary dynamics
Authors: Pu Xiaojun , Dong Xiumei , Li Qing , Chen Zexi , Liu Li 
Published: February 2021

AbstractIsoprenoids are among the largest and most chemically diverse classes of organic compounds in nature and are involved in the processes of photosynthesis, respiration, growth, development, and plant responses to stress. The basic building block units for isoprenoid synthesis—isopentenyl diphosphate and its isomer dimethylallyl diphosphate—are generated by the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways. Here, we summarize recent advances on the roles of the MEP and MVA pathways in plant growth, development and stress responses, and attempt to define the underlying gene networks that orchestrate the MEP and MVA pathways in response to developmental or environmental cues. Through phylogenomic analysis, we also provide a new perspective on the evolution of the plant isoprenoid pathway. We conclude that the presence of the MVA pathway in plants may be associated with the transition from aquatic to subaerial and terrestrial environments, as lineages for its core components are absent in green algae. The emergence of the MVA pathway has acted as a key evolutionary event in plants that facilitated land colonization and subsequent embryo development, as well as adaptation to new and varied environments.
The Bank Lending Channel of Conventional and Unconventional Monetary Policy
Authors: ALBERTAZZI UGO , NOBILI ANDREA , SIGNORETTI FEDERICO M. 
Published: February 2021

AbstractUsing bank‐level information on lending rates, we study the transmission of conventional and unconventional monetary policy measures in the euro area via shifts in the supply of credit. For conventional operations, we find that the transmission is stronger for weaker banks, in line with the standard predictions of the bank‐lending channel literature. For nonstandard measures, instead, the monetary accommodation was transmitted more by banks with stronger capital and funding positions and characterized by a higher exposure to government bonds.