bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-Choline PET-CT: a potential adjuvant tool for early diagnosis of Osteonecrosis of the Jaw (ONJ) in prostate cancer patients?
Authors: Fusco Vittorio , Tommasi Luigi , Muni Alfredo , Fasciolo Antonella , Guglielmini Pamela Francesca , Vincenti Maura , Tartara Daniela , Brigo Paola 
Published: May 2021

Background. Nuclear Medicine imaging techniques, i.e., planar bone scan (Tc99 m scintigraphy) and PET (Positron Emission Tomography) with several tracers, have been sug­gested as useful aids to diagnosis of Osteonecrosis of Jaw (ONJ), that is mostly based on clinical observation (signs and symptoms, with/without bone exposure) and Computed Tomography (CT) scan. Potential advantages of Nuclear Medicine techniques include very early detection of ONJ (due to precocious uptakes), especially in ONJ cases without frank bone exposure. Prostate cancer patients treated with bisphosphonates or denosumab are at risk of ONJ. They undergo bone scan and/or 18F-Choline PET-CT aimed to evaluate response to treatment but attention is generally pointed to extracranial uptakes. Literature data show ability of bone scan to detect maxillary and mandible areas at risk of clinically relevant ONJ, but data are lacking about 18F-Choline PET-CT.

Material and Methods. We retrospectively reviewed 18F-Choline PET-CT scans of prostate cancer patients with diagnosis of ascertained ONJ (at CT scan) to search for uptakes in maxillary bones and mandible at time of ONJ diagnosis, or before, or after.

Results. Out of 5 prostate cancer patients undergoing 18F-Choline PET-CT scans before or after the ONJ diagnosis time, 4 had clear jaw uptakes at ONJ site next to ONJ diagnosis time or before; one had no uptake (4 years after ONj diagnosis).

Conclusions. Our limited experience indicates that 18F-Choline PET-CT scan uptakes, as well as planar bone scan uptakes, are of potential help to early detect ONJ areas, sometimes still in absence of signs and symptoms. Further studies with larger numbers of prostate cancer patients with and without ONJ disease are warranted and should be planned as multicentre trials.

The 18F-Choline PET-CT scan uptakes at maxillary bone and mandible should be reported and underlined by Nuclear Medicine specialists, as well as bone scan uptakes, as an aid to oncologists, oral care specialists and patients.
Workload Optimization by Horizontal Aggregation in SQL for Data Mining Analysis
Authors: Rathod Prasanna M. , Raut Prof. Dr. Anjali B. 
Published: May 2021

Preparing a data set for analysis is generally the most time consuming task in a data mining project, requiring many complex SQL queries, joining tables, and aggregating columns. Existing SQL aggregations have limitations to prepare data sets because they return one column per aggregated group. In general, a significant manual effort is required to build data sets, where a horizontal layout is required. We propose simple, yet powerful, methods to generate SQL code to return aggregated columns in a horizontal tabular layout, returning a set of numbers instead of one number per row. This new class of functions is called horizontal aggregations. Horizontal aggregations build data sets with a horizontal denormalized layout (e.g., point-dimension, observation variable, instance-feature), which is the standard layout required by most data mining algorithms. We propose three fundamental methods to evaluate horizontal aggregations:
?	CASE: Exploiting the programming CASE construct;
?	SPJ: Based on standard relational algebra operators (SPJ queries);
?	PIVOT: Using the PIVOT operator, which is offered by some DBMSs.
Experiments with large tables compare the proposed query evaluation methods. Our CASE method has similar speed to the PIVOT operator and it is much faster than the SPJ method. In general, the CASE and PIVOT methods exhibit linear scalability, whereas the SPJ method does not. For query optimization the distance computation and nearest cluster in the k-means are based on SQL.
Workload balancing is the assignment of work to processors in a way that maximizes application performance. The process of load balancing can be generalized into four basic steps:
1. Monitoring processor load and state;
2. Exchanging workload and state information between processors;
3. Decision making;
4. Data migration.
The decision phase is triggered when the load imbalance is detected to calculate optimal data redistribution. In the fourth and last phase, data migrates from overloaded processors to under-loaded ones.
Analisis Kinerja Sensor Water Level - Pressure Transducer (Studi Kasus Automatic Weather System Di Pelabuhan Merak)
Authors: Sandro Tiven , Hairatunnisa Hairatunnisa , Putra Maulana 
Published: May 2021

Pengukuran tinggi muka air laut (water level) merupakan salah satu pengukuran parameter cuaca yang sangat penting di Indonesia mengingat wilayah Indonesia didominasi wilayah perairan. Pengukuran water level dimaksudkan sebagai data peringatan dini untuk mencegah kerugian yang ditimbulkan dari bencana seperti tsunami ataupun pasang gelombang yang tinggi. Dalam melakukan pengukuran water level terdapat beberapa jenis sensor yang digunakan, salah satunya adalah sensor dengan tipe pressure atau tekanan. Pada penelitian ini digunakan sensor water level pressure transducer tipe CS451 yang prinsip kerjanya adalah dengan membandingkan tekanan yang ada di dalam air dengan tekanan udara sebagai referensi dan menghitung selisih antara kedua tekanan tersebut. Selisih yang didapatkan kemudian di konversikan menjadi jarak. Metode yang digunakan dalam penelitian ini terdiri dari dua tahapan yaitu perancangan sistem alat dan evaluasi kinerja alat. Pengukuran yang dilakukan pada tanggal 16 Desember 2019 – 31 Januari 2020 menunjukan data yang baik dimana data tersebut membentuk grafik sinusiodal dengan data rata-rata 1.466 m, nilai data maksimum 2.066 m dan nilai data minimum 0.821 m. Namun sensor water level mengalami permasalahan yang menyebabkan pengukuran yang dihasilkan menjadi tidak baik. Hal ini disebabkan salah satunya biota laut yaitu teritip yang menutupi sensor water level dan laju korosi pada sensor yang menyebabkan kerusakan pada sensor. Solusi yang harus dilakukan adalah dengan melakukan instalasi dan pemeliharaan dengan lebih baik, selain itu menggunakan cat anti-fouling agar kedepannya permasalahan yang sama tidak terulang kembali.
KAJIAN TAHAPAN PRA-STABILISASI MENGGUNAKAN ABU VULKANIK TERHADAP STABILISASI TANAH LEMPUNG ORGANIK ARTIFISIAL DENGAN SEMEN UNTUK DESAIN JOINTED PLAIN CONCRETE PAVEMENT
Authors: Upa Verdy Ananda , Setyadi Rahmat , Hakim Abi Maulana 
Published: May 2021

Tanah lempung lunak adalah jenis tanah lempung yang memiliki nilai CBR rendah dan swelling yang besar, selain itu bahan organik dalam tanah lempung tersebut harus menjadi bahan pertimbangan, karena jika melewati batas maksimum akan mereduksi kekuatan dan stabilitas dari proses stabilisasinya. Tujuan penelitian ini untuk mengetahui pengaruh penambahan abu vulkanik dan semen Portland terhadap kekuatan dan stabilitas tanah lempung organik artifisial serta tebal perkerasan rencana yang digunakan. Tahap perlakuan awal, tanah lempung lunak dicampur dengan 3 variasi kadar abu vulkanik, kemudian diperam selama 3 hari. Tahap perlakuan akhir, tanah hasil campuran ditambahkan 5% semen Portland, lalu kembali diperam selama 3 hari. Pengujian sifat fisis meliputi specific gravity, batas cair, batas plastis. Specific gravity meningkat dari 2,58 menjadi 2,65, batas cair menurun dari 71,48% menjadi 43,45%, batas plastis meningkat dari 28,96% menjadi 34,08%, indeks plastisitas menurun dari 42,52% menjadi 9,37%. Pengujian sifat mekanis meliputi pemadatan, CBR, dan pengujian swelling. OMC mengalami penurunan dari 33,696% menjadi 29,586%, MDD mengalami peningkatan dari 1,319% menjadi 1,351%, CBR mengalami peningkatan dari 2,87% menjadi 9,77%, dan swelling mengalami penurunan dari 2,36% menjadi 0,45%, serta tebal perkerasan rencana berkurang dari 15 cm menjadi 8 cm untuk campuran tanah lempung organik dengan 15% abu vulkanik dan 5% semen.
Egg quality in different lines of New Hampshire and Giriraja chicken
Authors: Baskota N , Sharma M , Bhattrai N , Neupane D , Yadav RK , Upreti S 
Published: May 2021

This study was undertaken to evaluate the egg quality parameters of New Hampshire and Giriraja by maintaining four different flocks (lines) of New Hampshire viz. NH-Khajura, NH-Parwanipur, NH-Khumaltar and NH-Pokhara and three different flocks (lines) of Giriraja viz. GR-Pakhribas, GR-Khumaltar and GR-Tarhara. The 40-60 weeks of hatchability, fertility, external and internal egg quality parameters were studied and recorded. A total of 200 birds (40 weeks of age) of each New Hampshire and Giriraja from each line were maintained on deep litter system. Results from this study indicated the significant effect of genotype and respective lines on fertility and hatchability of eggs. Significant (P<0.05) variation in fertility and no significant variation in hatchability for genotypes were found. However, in terms of fertility and hatchability, there were significant variations in different lines. In case of egg weight: no significant (P<0.01) variation was obtained for genotype but lines comparison showed significant variation. Other external egg quality parameters like egg length, egg diameter, shape index, shell thickness were examined for evaluating the genotype and line effect. In all these external egg quality parameters, there were significant (P<0.01) effect of both genotype and lines of birds. For internal egg qualities, yolk weight (g), yolk index, albumen weight and albumen index were checked. Genotype had no significant (P<0.01) effect but lines had significant (P<0.01) effect on yolk weight. In case of yolk index, both genotype and lines of bird had no significant effect. For albumen weight and albumen index, genotype of birds had no significant (P<0.01) effect but lines of bird had significant (P<0.01) effect on both parameters. The study showed that the egg quality parameters of NH (Khajura) were better than that of GR. Among different lines New Hampshire (Khajura) showed better performance in terms of egg quality parameter.
Bang. J. Anim. Sci. 2020. 49 (2): 108-118
A Task Scheduling Approach for Cloud Environments Employing Evolutionary Algorithms
Authors: Lakhani B. , Agrawal A. 
Published: May 2021

One of the key challenges in the domain of cloud computing is task scheduling and estimation of cloud workloads for time critical applications pertaining to constrained cloud resources. While effective task scheduling is necessary for balancing the load, workload forecasting is necessary to plan in advance the requirements of cloud platforms based on previous data so as to effectively utilize cloud resources. Often it is challenging to gather sufficient information about the tasks and hence allocating the tasks to virtual machines (VMs) in the most optimal way is non-trivial. In this paper, a hybrid task scheduling approach is proposed based on evolutionary algorithms. The first approach is the amalgamation of bat and particle swarm optimization (PSO) techniques. The scheduling approach also combines the processing time preemption (PTP) approach to schedule the source intensive tasks which allows to reduce the response time of the proposed system. The second approach is a machine learning based approach employing gradient descent with momentum (GDM). The evaluation of the proposed system has been done based on the response time and mean square error of the system.
L(2,1,1)-Labeling of Circular-Arc Graphs
Authors: Amanathulla S. , Bera B. , Pal M. 
Published: May 2021

Graph labeling problem has been broadly studied in recent past for its wide applications, in mobile communication system for frequency assignment, radar, circuit design, X-ray crystallography, coding theory, etc. An L211-labeling (L211L) of a graph G = (V, E) is a function γ : V → Z∗ such that |γ(u) − γ(v)| ≥ 2, if d(u, v) = 1 and |γ(u) − γ(v)| ≥ 1, if d(u, v) = 1 or 2, where Z∗ be the set of non-negative integers and d(u, v) represents the distance between the nodes u and v. The L211L numbers of a graph G, are denoted by λ2,1,1(G) which is the difference between largest and smallest labels used in L211L. In this article, for circular-arc graph (CAG) G we have proved that λ2,1,1(G) ≤ 6∆ − 4, where ∆ represents the degree of the graph. Beside this we have designed a polynomial time algorithm to label a CAG satisfying the conditions of L211L. The time complexity of the algorithm is O(n∆2), where n is the number of nodes of the graph G.
PENGEMBANGAN LABORATORIUM VIRTUAL UNTUK MENINGKATKAN PENGUASAAN KONSEP PADA MATERI SISTEM SIRKULASI
Authors: Sukenti Evi 
Published: May 2021

Tujuan penelitian ini adalah mengembangkan Laboratorium Virtual untuk meningkatkan penguasaan konsep pada materi sistem sirkulasi. Laboratorium virtual ini dikembangkan sebagai salah satu alternatif solusi keterbatasan sarana dan prasarana laboratorium IPA untuk kegiatan praktikum yang mampu meningkatkan penguasaan konsep. Perkembangan teknologi informasi saat ini sudah sangat mendukung untuk melaksanakan simulasi paktikum dalam bentuk laboratorium virtual. Metode penelitian yang digunakan adalah metode pengembangan atau Research and Development (RD) dengan desain 4-D yang dimodifikasi menjadi 3-D. Langkah pengembangan meliputi: 1) pengidentifikasian berupa analisis kebutuhan dan studi pendahuluan, 2) perancangan berupa pemilihan model, media, penyusunan tes, pemilihan format berupa flowchart dan 3) pengembangan, berupa pembuatan media dengan menggunakan macromedia flash CS6 dan validasi ahli media, ahli materi dan pengguna media untuk menilai kelayakan media dan uji pengembangan untuk melihat efektivitas penggunaan media dalam pembelajaran serta tanggapan peserta didik terhadap efektivitas pembelajaran dengan menggunakan media laboratorium virtual. Uji kelayakan media laboratorium virtual oleh ahli media sangat baik dengan prosentase 95%. Hasil uji kelayakan media laboratorium virtual oleh ahli materi sangat baik dengan prosentase 82,14% dan hasil uji kelayakan media oleh tenaga pendidik sebagai pengguna media katagori sangat baik dengan prosentase 94% . Pembelajaran menggunakan media laboratorium virtual pada materi sistem sirkulasi efektif dalam meningkatkan penguasaan konsep, ditunjukkan dengan rata-rata N-Gain sebesar 31,38%.
KREATIVITAS PESERTA DIDIK DALAM PEMBELAJARAN BIOTEKNOLOGI DENGAN PJBL BERBASIS STEAM
Authors: Fatma Heryani 
Published: May 2021

Penelitian ini bertujuan untuk mengetahui kreativitas belajar biologi peserta didik kelas 11 IPA .4 SMAN I Parung kabupaten Bogor,pada konsep Bioteknologi, dengan model pembelajaran PJBL ( Projek Based Learning ) bebasis STEAM ( Saint Teknologi Engenering Art Matematic ) Jenis penelitian best praktis dengan teknik penelitiannya analisis deskriptif. Teknik pengumpulan data yang digunakan berupa teknik analisis data yang menggunakan lembar pengamatan dan lembar soal esay test .Subjek pada penelitian ini adalah peserta didik kelas 11 IPA.4 SMAN I Parung yang berjumlah 36 orang terdiri dari laki laki 13 orang , perempuan 23 orang.waktu penelitian pada bulan Nopember 2019 (semester ganjil tahun pelajran 2019/2020). Hasil yang diperoleh, Kreativitas belajar peserta didik dengan menggunakan model pembelajaran Projek Based learning ( PJBL) berbasis STEAM pada kelas 11 IPA.4 SMAN I Parung .Hasil yang diperoleh dari penelitian ini untuk tiap indicator kreativitas adalah sebagai berikut : fleksibilitas 94,4 %,Orginalitas 97,2 %, Elaborasi 100 %,fluency 91,6 % . indicator tertinggi diperoleh pada elaborate yaitu 100%, dan perolehan terrendah pada indicator fluency sebesar 91,6 dengan rata rata dari ke empat indicator sebesar 95,8% dengan kriteria sangat baik.Dalam penelitian best praktis ini juga didapat hasil belajar yang baik yaitu rata rata nilai kelas 85. Nilai rata rata 85 ini merupakan nilai rata rata di atas kriteria ketuntasan minimal (KKM) yaitu 75 ,BEST PRACTICE
PENINGKATAN KOMPETENSI GURU MATA PELAJARAN DALAM PEMBUATAN RPP MELALUI KEGIATAN MGMP SEKOLAH DI SMP NEGERI 3 DEPOK
Authors: Iriani Erna 
Published: May 2021

Penelitian Tindakan Sekolah. Peningkatan Kompetensi Guru Mata Pelajaran dalam Pembuatan Rencana Pelaksanaan Pembelajaran Kurikulum 2013 melalui Kegiatan MGMP Sekolah di SMP Negeri 3 Depok Tahun 2019. Penelitian ini bertujuan mengetahui efektifitas MGMP sebagai wadah peetemuan Guru mata pelajaran sejenis untuk memecahkan masalah, terutama dalam hal pembuatan RPP kurikulum 2013. Penelitian ini dilaksanakan selama 3 bulan sejak bulan Agustus sampai awal nopember 2019. Untuk melihat efektifitas kegiatan, maka MGMP Sekolah sementara hanya dilaksanakan pada guru mata pelajaran yang di Ujian Nasionalkan, seperti Bahasa Indonesia, Matematika, Bahasa Inggris dan IPA, berjumlah 21 orang guru. Sebelum dilakukan kegiatan MGMP sekolah pada umumnya Para guru kebingungan dalam menyusun Rencana Pelaksanaan Pembelajaran sesuai dengan Peraturan Mentri Pendidikan no 103 tahun 2014. Penelitian ini dilaksanakan selama dua siklus , tiap siklusnya terdiri dari tahap perencanaan, pelaksanaan, observasi dan refleksi. Hasil refleksi siklus pertama kemudian dijadikan awalan bagi siklus kedua dan seterusnya. Untuk melihat Hasil keja Guru mata Pelajaran dalam membuat RPP Kurilas, maka dilakukan penelahaan RPP dengan menggunakan format telaah RPP, sebanyak 8 item dan 43 butir indikator. Hasil telaah RPP dengan menggunakan format telah RPP yang terdiri dari 8 item yaitu Identitas Mata pelajaran, Kompetensi Inti dan Kompetensi Dasar, Petumusan Indikator, Perumusan Tujuan pembelajaran, Pemilihan Bahan ajar, Pemilihan sumber belajar, Pemilihan Media Belajar, Model Pembelajaran, Metode Pembelajaran, Skenario Pembelajaran dan Rancangan Penilaian pembelajaran, dengan skala 1 sampai 3. Ketentuan diberi skor 1 jika tidak sesuai / tidak lengkap, diberi skor 2 jika Sesuai sebagian atau kurang lengkap, dan diberi skor 3 jika sesuai atau lengkap. Dari 8 item tersebut diuraikan dalam 41 butir instrumen, sehingga skor maksimal sebesar 123 point. Hasil penelitian pada siklus 1 ini diperoleh jumlah nilai 1730, 89 dengan rata rata nilai 82,27. Nilai tertinggi diperoleh sebesar 96,75 sedangkan skor terendah sebesar 72,36. Hasil penelitian siklus kedua Dari 8 item tersebut diuraikan dalam 41 butir instrumen, sehingga skor maksimal sebesar 123 point. Hasil penelitian pada siklus 2 ini diperoleh jumlah nilai 1956,10 dengan rata rata nilai 93,15. Nilai tertinggi diperoleh sebesar 99,19 sedangkan skor terendah sebesar 82,11 Data yang diperoleh kemudian diolah dengan menggunakan SPSS ver. 20.0 untuk memperoleh gambaran dan penyebaran data yang diperoleh.
Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity
Authors: Vreeken Dianne , Bruikman Caroline Suzanne , Stam Wendy , Cox Stefan Martinus Leonardus , Nagy Zsófia , Zhang Huayu , Postma Rudmer Johannes , van Zonneveld Anton Jan , Hovingh Gerard Kornelis , van Gils Janine Maria 
Published: May 2021

Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are emerging as regulators of atherosclerosis, we set out to investigate the expression and function of inflammation-regulated NGCs.Methods and results: NGC expression in human monocytes and endothelial cells was assessed using a publicly available RNA dataset. Next, the mRNA levels of expressed NGCs were analyzed in primary human monocytes and endothelial cells after stimulation with IL1β or TNFα. Upon stimulation a total of 14 and 19 NGCs in monocytes and endothelial cells, respectively, were differentially expressed. Since plexin A4 (PLXNA4) was strongly downregulated in endothelial cells under inflammatory conditions, the role of PLXNA4 in endothelial function was investigated. Knockdown of PLXNA4 in endothelial cells markedly impaired the integrity of the monolayer leading to more elongated cells with an inflammatory phenotype. In addition, these cells showed an increase in actin stress fibers and decreased cell-cell junctions. Functional assays revealed decreased barrier function and capillary network formation of the endothelial cells, while vascular leakage and trans-endothelial migration of monocytes was increased.Conclusion: The current study demonstrates that pro-inflammatory conditions result in differential expression of NGCs in endothelial cells and monocytes, both culprit cell types in atherosclerosis. Specifically, endothelial PLXNA4 is reduced upon inflammation, while PLXNA4 maintains endothelial barrier function thereby preventing vascular leakage of fluids as well as cells. Taken together, PLXNA4 may well have a causal role in atherogenesis that deserves further investigation.
Deriving Planform Morphology and Vegetation Coverage From Remote Sensing to Support River Management Applications
Authors: Boothroyd Richard J. , Nones Michael , Guerrero Massimo 
Published: May 2021

With the increasing availability of big geospatial data (e.g., multi-spectral satellite imagery) and access to platforms that support multi-temporal analyses (e.g., cloud-based computing, Geographical Information Systems, GIS), the use of remotely sensed information for monitoring riverine hydro-morpho-biodynamics is growing. Opportunities to map, quantify and detect changes in the wider riverscape (i.e., water, sediment and vegetation) at an unprecedented spatiotemporal resolution can support flood risk and river management applications. Focusing on a reach of the Po River (Italy), satellite imagery from Landsat 5, 7, and 8 for the period 1988–2018 were analyzed in Google Earth Engine (GEE) to investigate changes in river planform morphology and vegetation dynamics associated with transient hydrology. An improved understanding of these correlations can help in managing sediment transport and riparian vegetation to reduce flood risk, where biogeomorphic processes are commonly overlooked in flood risk mapping. In the study, two established indices were analyzed: the Modified Normalized Difference Water Index (MNDWI) for monitoring changes in the wetted river planform morphology, inferring information about sediment dynamics, and the Normalized Difference Vegetation Index (NDVI) for evaluating changes in vegetation coverage. Results suggest that planform changes are highly localized with most parts of the reach remaining stable. Using the wetted channel occurrence as a measure of planform stability, almost two-thirds of the wetted channel extent (total area = 86.4 km2) had an occurrence frequency &gt;90% (indicating stability). A loss of planform complexity coincided with the position of former secondary channels, or zones where the active river channel had narrowed. Time series analysis of vegetation dynamics showed that NDVI maxima were recorded in May/June and coincided with the first peak in the hydrological regime (occurring in late spring and associated with snowmelt). Seasonal variation in vegetation coverage is potentially important for local hydrodynamics, influencing flood risk. We suggest that remotely sensed information can provide river scientists with new insights to support the management of highly anthropized watercourses.