bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Can We Understand and Describe “Non‐Narrative” Narratives? A Qualitative Study of Workers with Recurring Sick Leave
Authors: Noda Miki , Oyama Yasuhiro 
Published: January 2021

AbstractThis study explored methodologies enabling us to hear the “non‐narrative” voices of participants in narrative research. Individual semi‐structured interviews were conducted with seven Japanese workers with recurring sick leave, and the data were analyzed using thematic analysis (TA) and dialogical narrative analysis (DNA). In narrators' apparently chaotic and fragmented statements, TA identified three divided self‐images that remained disconnected: image of present self with a sense of setbacks, image of past self, and image of ideal self. As the last two self‐images ceaselessly negate the first, these workers had lost a sense of autonomy and self‐confidence. On the other hand, DNA described their desperate endeavors to organize their sick leave experiences by appealing to the typology of the illness narrative; however, this effort remained a failure. Through two qualitative analyses that suspended the premise that each narrative enables the narrator's construction of self, we were able to understand the real status of participants who could not narrate their experiences. The ethical obligation of researchers to respect the “unfinalizability” of narrative and remain open to continuous dialogue is discussed.
Obesogenic home food availability, diet, and BMI in Pakistani and White toddlers
Authors: LeCroy Madison N. , Bryant Maria , Albrecht Sandra S. , Siega‐Riz Anna Maria , Ward Dianne S. , Cai Jianwen , Stevens June 
Published: January 2021

AbstractIndividuals of South Asian ethnicity have an increased risk for obesity and related diseases. Foods available in the home during the first 1000 days (conception to 24 months old) are an important determinant of diet, yet no study has examined the association of early‐life home food availability (HFA) with later diet and obesity risk in South Asian households. We examined whether obesogenic HFA at 18 months of age is associated with dietary intake and body mass index (BMI) at 36 months of age in low‐income Pakistani and White households in the United Kingdom. In this prospective birth cohort study (Born in Bradford 1000), follow‐up assessments occurred at 18 (n = 1032) and 36 (n = 986) months of age. Variety and quantity of snack foods and sugar‐sweetened beverages (SSBs) in the home and consumed were measured using the HFA Inventory Checklist and food frequency questionnaires, respectively. BMI was calculated using measured length/height and weight. Multinomial logistic regression models examined associations between HFA and tertiles of dietary intake, and multivariable linear regression models assessed associations between HFA and BMI. Pakistani households had a greater variety and quantity of snack foods and SSBs available compared with White households. Variety and quantity of snack foods and SSBs in the home at 18 months were positively associated with children's intake of these items at 36 months, but associations between HFA and BMI were null. Reducing obesogenic HFA during the first 1000 days may promote the development of more healthful diets, though this may not be associated with lower obesity risk during toddlerhood.
Patients Undergoing Primary Total Joint Arthroplasty with Primary Hypercoagulable States
Authors: Pan Xin , Shi Zhe , Shi Zhan‐jun , Yang Zhang , Lin Ze‐ming , Wu Xuan‐ping , Wang Jian 
Published: January 2021

ObjectiveTo analyze perioperative complications, resource consumption, and inpatient mortality of patients who receive total joint arthroplasty (TJA) with a concomitant diagnosis of a primary hypercoagulable state (PHS). The following questions were posed in the present paper. First, do patients undergoing TJA with PHS have increased risk of deep venous thrombosis (DVT), pulmonary embolism (PE), and periprosthetic joint infection (PJI)? Second, what other in‐hospital complications are more likely among PHS patients undergoing TJA? Third, do TJA patients with PHS usually consume greater in‐hospital resources? Fourth, do PHS patients suffer higher mortality rates compared to non‐PHS patients? Finally, have PHS patients received proper anticoagulant management in past arthroplasties?MethodsThe National Inpatient Sample (NIS) database for the years between 2003 and 2014 was searched to identify patients undergoing primary TJA. Patients with PHS were identified with the ICD‐9‐CM code 289.81. The χ2‐test, the Pearson test, and adjusted multivariate regression analysis were performed to evaluate the difference and odds ratios between the positive and negative diagnosis groups.ResultsFrom 2003 to 2014, a total of 2,044,356 patients were identified in the NIS as undergoing primary total hip arthroplasty (THA) or total knee arthroplasty (TKA) in the United States. A total of 4664 patients (0.2%) were identified as having PHS. Compared with the non‐PHS group, TJA patients with PHS had a higher risk of DVT (THA: odds ratio [OR] = 8.343, 95% CI: 5.362–12.982, P < 0.001; TKA: OR = 4.712, 95% CI: 3.560–6.238, P < 0.001) but did not have increased risk of PE (THA: OR = 1.306, 95% CI: 0.48–3.555, P = 0.602; TKA: OR = 1.143, 95% CI: 0.687–1.903), and only PHS patients in the THA group had higher risks of inpatient mortality (OR = 3.184, 95% CI: 1.348–7.522, P = 0.008) and periprosthetic joint infection (OR = 3.343, 95% CI: 1.084–10.879, P = 0.036). In addition, PHS patients had extended length of stay, higher total costs, and increased risks of certain other complications, such as peripheral vascular disease, hemorrhage, and thrombophlebitis.ConclusionIn the present study, PHS patients had higher risks of DVT, greater in‐hospital resource consumption, and certain other perioperative complications. However, PHS was not associated with increased risk of PE in TJA patients in the United States between 2003 and 2014. While potential hazards of PHS have already been recognized, the present study revealed additional concerns and demonstrated that further improvements in the perioperative management of patients with hereditary hypercoagulable disorders are essential.
Successful kidney transplantation in a patient with neonatal‐onset ILNEB
Authors: Okamoto Takayuki , Nakamura Akie , Hayashi Asako , Yamaguchi Takeshi , Ogawa Yayoi , Natsuga Ken , Yanagi Kumiko , Hotta Kiyohiko 
Published: January 2021

AbstractBackgroundILNEB constitute an autosomal recessive disorder caused by homozygous or compound heterozygous mutation of the gene for the ITGA3. To date, 8 ILNEB patients have been reported, but all 6 neonatal‐onset ILNEB patients suffered early death within 2 years. The most common cause of death among previously reported ILNEB patients was exacerbation of the respiratory condition.MethodsIn this study, we describe a case of ILNEB with neonatal onset in a female patient and the genetic and histopathological testing performed.ResultsOur patient had a compound heterozygous mutation in ITGA3. Compared to previously reported patients, this patient exhibited milder clinical and histopathological characteristics. After experiencing a life‐threatening respiratory infection at 8 months old, the patient started periodic subcutaneous immunoglobulin treatment once every 1‐2 weeks for nephrotic‐range proteinuria‐induced secondary hypogammaglobulinemia. At the age of 3 years, proteinuria gradually increased with severe edema despite strict internal management. Therefore, our patient underwent unilateral nephrectomy and insertion of a peritoneal dialysis catheter followed by another unilateral nephrectomy. One month later, she underwent an ABO‐compatible living‐donor kidney transplantation at the age of 4 years.ConclusionsOur patient is a neonatal‐onset ILNEB patient who survived for more than 2 years and underwent successful kidney transplantation.
Validation of the Short‐Form Survivor Unmet Needs Survey in older patients with myeloma
Authors: Pereira Maria da Graça , Pereira Marta , Vilaça Margarida , Ferreira Gabriela , Faria Sara , Monteiro Sara , Bacalhau Rosário 
Published: January 2021

BackgroundMultiple myeloma (MM) affects mainly the older population and is the second most prevalent haematologic cancer. MM patients' unmet needs are diverse, arise at different stages, and are associated with greater psychological distress. This study examined the psychometric properties of the Short‐Form Survivor Unmet Needs Survey (SF‐SUNS) in Portuguese MM patients.MethodsThis cross‐sectional study included 213 MM patients. The internal consistency of the scale was analyzed with Cronbach's α. Principal component analysis and confirmatory factor analysis were used to assess construct validity. Convergent validity was examined by using correlations with quality of life, satisfaction with social support, and psychological morbidity. Multiple regression analyses were conducted to explore the contribution of sociodemographic and clinical variables to unmet needs.ResultsThe Portuguese SF‐SUNS's factor structure follows the original's structure, although it includes fewer items. For each domain, Cronbach's α was ≤0.70, the minimum acceptable criterion. For construct validity, only unmet relationship and emotional needs had significant correlations (r ≥ 0.40)—specifically negative associations with quality of life and social support and positive associations with psychological morbidity. Regarding patient variables and SF‐SUNS results, only cancer stage contributed significantly to unmet information needs, with patients at stage I reporting more needs than patients at stage III.ConclusionsThe SF‐SUNS represents a valid and reliable tool to assess unmet needs among Portuguese MM patients. It may be useful in designing and monitoring interventions to improve well‐being in cancer survivors.
Development of a Metric Concept that Differentiates Between Normal and Abnormal Operational Aviation Data
Authors: Stogsdill Matthew , Baranzini Daniele , Ulfvengren Pernilla 
Published: January 2021

AbstractThere is a strong and growing interest in using the large amount of high‐quality operational data available within an airline. One reason for this is the push by regulators to use data to demonstrate safety performance by monitoring the outputs of Safety Performance Indicators relative to targeted goals. However, the current exceedance‐based approaches alone do not provide sufficient operational risk information to support managers and operators making proximate real‐time data‐driven decisions. The purpose of this study was to develop and test a set of metrics which can complement the current exceedance‐based methods. The approach was to develop two construct variables that were designed with the aim to: (1) create an aggregate construct variable that can differentiate between normal and abnormal landings (row_mean); and (2) determine if temporal sequence patterns can be detected within the data set that can differentiate between the two landing groups (row_sequence). To assess the differentiation ability of the aggregate constructs, a set of both statistical and visual tests were run in order to detect quantitative and qualitative differences between the data series representing two landing groups prior to touchdown. The result, verified with a time series k‐means cluster analysis, show that the composite constructs seem to differentiate normal and abnormal landings by capturing time‐varying importance of individual variables in the final 300 seconds before touchdown. Together the approaches discussed in this article present an interesting and complementary way forward that should be further pursued.
Spillovers in global production networks
Authors: Frohm Erik , Gunnella Vanessa 
Published: January 2021

AbstractThis paper studies the role of global input–output linkages in transmitting economic disturbances in the international economy. Our empirical results find that these links are both statistically significant and of economic importance for generating spillovers. We also provide evidence that it is not the inter‐linkages per se that matter for the international transmission but rather the presence of global hub sectors that are either large suppliers or purchasers of other sectors' inputs. When the links between these sectors and the rest of the global value chain are severed, the spillovers diminish strongly and eventually become statistically insignificant. This highlights the importance of the structure of the production network for enabling spillovers and outlines the prominent role played by hub sectors in the global economy.
Development of a shear device for precise simple shear measurements of rubber mats
Authors: Kanzenbach Lars , Ihlemann Jörn 
Published: January 2021

AbstractThis contribution deals with the development of a new shear specimen, which allows precise simple shear measurements for large shear values. The main idea is that the shear load for the rubber mat is applied via steel pins. A form fit connection has the advantage that for the load application, no clamping force or high friction coefficient is required. In addition, the disadvantages resulting from vulcanisation or bonding, for example, shrinkage, are avoided. This offers the big advantage that homogeneous ageing tests can be performed, and also fibre‐reinforced materials can be tested. In order to show the potential of the new pin design, simulation results are compared to each other, and also a first experimental implementation is conducted. The new shear specimen can be used for phenomenological investigations of rubber properties, like Payne effect, Mullins effect, anisotropy, permanent set, softening, recovery, creep and relaxation behaviour.
A modular graph transformation rule set for IFC‐to‐CityGML conversion
Authors: Tauscher Helga , Lim Joie , Stouffs Rudi 
Published: January 2021

AbstractConversion of Industry Foundation Classes (IFC) building models into CityGML city models is one of the operational scenarios for BIM–GIS integration, with a variety of applications producing and consuming data on either side. Given the in‐depth cross‐domain knowledge required to specify such conversions, the heterogeneity of the IFC input data and the use cases for the resulting CityGML, flexible and configurable solutions are needed that make conversion details accessible to domain specialists. Graph transformation as a conversion method fulfils these requirements. We propose to extend the modularity given by single transformation rules at a more coarse‐grained level and identify four layers with modules of associated rules. We describe a self‐contained set of rules across these modules and demonstrate its application to a range of building models.
Bacterial contamination of blood products in Africa
Authors: Ahmad Yembur , Heroes Anne‐Sophie , Hume Heather A. , Farouk Mohammed , Owusu‐Ofori Alex , Gehrie Eric A. , Goel Ruchika , Ness Paul M. , Tobian Aaron A. R. , Bloch Evan M. 
Published: January 2021

AbstractBackgroundBacterial contamination of blood components (notably platelets) remains a leading infectious risk to the blood supply. There has been extensive research in high‐income countries to characterize the risk of bacterial contamination along with adoption of strategies to mitigate that risk. By contrast, related data in Africa are lacking.Study Design and MethodsAn electronic survey was distributed to members of African Society of Blood Transfusion to assess existing or planned measures at African blood centers and hospitals to mitigate bacterial contamination of blood products. A literature review of studies pertaining to related transfusion‐associated risk in Africa was conducted to complement the findings.ResultsForty‐five responses were received, representing 16 African countries. All respondents were urban, either in blood centers (n = 36) or hospital‐based transfusion services (n = 9). Reported measures included skin disinfection (n = 41 [91.1%]); diversion pouches (n = 14 [31.1%]); bacterial culture (n = 9 [20%]); pathogen reduction (PR) (n = 3 [6.7%]); and point‐of‐release testing (PoRT) (n = 2 [4.4%]). Measures being considered for implementation included: skin disinfection (n = 2 [4.4%]); diversion pouches (n = 2 [4.4%]); bacterial culture n = 14 (31.1%); PR (n = 11 [24.4%]); and PoRT (n = 4 [8.9%]). Of the 38 respondents who reported collection of platelets, 14 (36.8%) and 8 (21.1%) reported using diversion pouches and bacterial culture, respectively. The literature review identified 36 studies on the epidemiology of bacterial contamination and septic transfusion reactions in Africa; rates of contamination ranged from 0% to 17.9%.ConclusionsThe findings suggest that prevention of bacterial contamination of blood components and transfusion‐associated sepsis in Africa remains neglected. Regional preventive measures have not been widely adopted.
The effect of restrictive measures on cross‐border investment in the European Union
Authors: Gregori Wildmer Daniel , Nardo Michela 
Published: January 2021

AbstractThis study sheds light on the effect of restrictive policies, such as screening procedures, on mergers and acquisitions (M&A) flows into EU Member States in the period 2011–18. By implementing an augmented gravity model, we show that different restrictive measures affect cross‐border investments unevenly. The presence of formal screening procedures per se does not negatively affect cross‐border investments on average. The exception is M&As flows from tax havens that are negatively affected by the presence of screening procedures in the target country. Other restrictive policies such as licensing requirements, quantitative limitations, restrictions to the market access and operation of foreign companies limit M&A flows. This is particularly relevant in manufacturing and nonfinancial services where M&A flows are negatively influenced by restrictions on foreign personnel being employed in key positions, and restrictions on the establishment of branches, land acquisition or profit and capital repatriations.
Immunopathogenesis of the feline atopic syndrome
Authors: Halliwell Richard , Banovic Frane , Mueller Ralf S. , Olivry Thierry 
Published: January 2021

RésuméContexteLes maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la dermatologie.ObjectifsDécrire le statut de recherche de l’immunopathogénie des maladies qui tombent dans le spectre du syndrome cutané atopique félin (FASS), résumer les conclusions, identifier les limites et recommander de futures directions de recherche.MéthodesUne étude bibliographique a été réalisée. Les forces et la validité des données et des contributions à nos connaissances actuelles sur l’immunopathogénie ont été analysées. Les dermatoses présumées d’origine allergique et l’asthme, ont été évalués séparément, ainsi que le rôle des anticorps, cellules et cytokines.RésultatsLa qualité des recherches était variée et ses impacts étaient souvent limités par un défaut d’utilisation de critères stricts de sélection des cas. Ceci reflète les difficultés des patrons de réaction cutanée associée à un grand nombre d’étiologies. La recherche sur l’asthme félin a été freinée par les difficultés d’explorer le matériel clinque et la plupart des informations utiles était dérivées de modèles expérimentaux.Conclusions et importance CliniqueLa revue des preuves supporte le rôle de l’immunoglobuline (Ig)E dans la pathogénie de l’asthme et du FASS quoique pas fortement. L’inflammation notée dans le FASS et l’asthme est accompagnée d’éosinophiles et de lymphocytes, et ces données, ensemble avec l’expression de cytokines, suggèrent d’une dérégulation immunitaire des T‐helper type 2 de certains chats (mais pas tous).
Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies
Authors: Helston Olivia , Amaya Enrique 
Published: January 2021

AbstractIn humans, myocardial infarction (MI) is associated with irreversible damage to heart tissue, resulting in increased morbidity and mortality in patients. By comparison, the zebrafish (Danio rerio) is capable of repairing damaged and injured hearts by activating a full regenerative response. By studying model organisms that can regenerate loss heart tissue following injury, such as the zebrafish, a greater insight will be gained into the molecular pathways that can induce and sustain a regenerative response following injury. There is hope that such information may lead to new treatments or therapies aimed at stimulating a better regenerative response in humans that have suffered heart attacks. Recent findings in zebrafish have highlighted an important role for sustained elevated levels of Reactive Oxygen Species (ROS), including hydrogen peroxide (H2O2) in the promotion of a regenerative response. Given that elevated levels of H2O2 can be harmful, simply elevating ROS levels directly may not be easy or practical to translate clinically. An alternative approach would be to identify the critical downstream targets of ROS in the promotion of heart regeneration, and then target these clinically using drugs. One such family of potential downstream targets of ROS during heart regeneration are the family of protein tyrosine phosphatases (PTPs), which are known to be exquisitely sensitive to redox regulation and whose inhibition have been linked to the promotion of heart regeneration in zebrafish. In this review, we present an overview of the zebrafish as a model organism for studying cardiac regeneration, including the molecular mechanisms by which cardiac regeneration occurs in response to injury. We then present recent findings linking elevated ROS levels to heart regeneration and their potential downstream targets, the PTPs, including protein tyrosine phosphatase 1B (PTP1B) and the dual specificity phosphatase 6 (DUSP6) in the promotion of heart regeneration.