bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylaxis Against Thromboembolic Events During Chemotherapy for Germ Cell Cancer
Authors: Meng Xiaosong , Ahmed Murtaza , Courtney Kevin D. , Arafat Waddah , Ibrahim Ibrahim , Margulis Vitaly , Nichols Craig , Bagrodia Aditya 
Published: October 2021

IntroductionPatients with advanced germ cell tumors (GCT) receiving cisplatin-based chemotherapy have high rates of thromboembolic events (TEE) which can negatively affect their overall survival. While primary TEE prophylaxis during chemotherapy may prevent these events, it is unclear which patients will benefit in this setting.Materials and MethodsA review of PubMed/Medline was conducted in December 2020 and all pertinent articles were evaluated for relevancy and quality of data for inclusion in the review.ResultsStudies on patients receiving initial cisplatin-based chemotherapy for advanced GCT have reported up to a 19% rate of TEE. This high rate may be associated with multiple factors including retroperitoneal lymphadenopathy, advanced clinical stage, high risk Khorana scores and presence of a central line. Large phase III clinical trials have demonstrated the benefit of low-molecular-weight-heparin and direct oral anticoagulants for primary prophylaxis and against recurrent TEE. However, primary prophylaxis is currently underutilized with GCT patients starting chemotherapy.ConclusionPrecise models to predict TEE risk and consideration of anticoagulation are difficult to develop owing to the relatively uncommon nature of GCT and lack of representation in primary TEE prophylaxis clinical trials. Despite these limitations, we believe that the benefits of prophylactic anticoagulation outweigh the risk of major bleeding in select GCT patients with higher risk of TEE. We have developed a simple algorithm to help guide TEE prophylaxis selection based on patient factors and route of chemotherapy administration. Given the high rate of TEE in GCT patients, we believe better utilization of primary prophylaxis in patient starting cisplatin-based chemotherapy will have clinical benefit.
Effects of Cytochrome P450 and Transporter Polymorphisms on the Bioavailability and Safety of Dutasteride and Tamsulosin
Authors: Villapalos-García Gonzalo , Zubiaur Pablo , Navares-Gómez Marcos , Saiz-Rodríguez Miriam , Mejía-Abril Gina , Martín-Vílchez Samuel , Román Manuel , Ochoa Dolores , Abad-Santos Francisco 
Published: October 2021

Dutasteride and tamsulosin are one of the first-line combination therapies for the management of benign prostatic hyperplasia (BPH). Despite being more effective than monotherapies, they produce frequent adverse drug reactions (ADRs). Institutions such as Food and Drug Administration and European Medicines Agency recommend precaution with CYP2D6 poor metabolizers (PMs) that receive CYP3A4 inhibitors and tamsulosin. However, no specific pharmacogenetic guideline exists for tamsulosin. Furthermore, to date, no pharmacogenetic information is available for dutasteride. Henceforth, we studied the pharmacokinetics and safety of dutasteride/tamsulosin 0.5 mg/0.4 mg capsules according to 76 polymorphisms in 17 candidate pharmacogenes. The study population comprised 79 healthy male volunteers enrolled in three bioequivalence, phase-I, crossover, open, randomized clinical trials with different study designs: the first was single dose in fed state, the second was a single dose in fasting state, and the third was a multiple dose. As key findings, CYP2D6 PMs (i.e., *4/*4 and *4/*5 subjects) and intermediate metabolizers (IMs) (i.e., *1/*4, *1/*5, *4/*15 individuals) presented higher AUC (p = 0.004), higher t1/2 (p = 0.008), and lower Cl/F (p = 0.006) when compared with NMs (*1/*1 individuals) and UMs (1/*1 × 2 individuals) after multiple testing correction. Moreover, fed volunteers showed significantly higher tmax than fasting individuals. Nominally significant associations were observed between dutasteride exposure and CYP3A4 and CYP3A5 genotype and between tamsulosin and ABCG2, CYP3A5, and SLC22A1 genotypes. No association between the occurrence of adverse drug reactions and genotype was observed. Nonetheless, higher incidence of adverse events was found in a multiple-dose clinical trial. Based on our results, we suggest that dose adjustments for PMs and UMs could be considered to ensure drug safety and effectiveness, respectively. Further studies are warranted to confirm other pharmacogenetic associations.
Suppression of PTRF Alleviates Post-Infectious Irritable Bowel Syndrome via Downregulation of the TLR4 Pathway in Rats
Authors: Zhou Hui-hui , Zhang Ye-ming , Zhang Sheng-peng , Xu Qi-xiang , Tian Ya-qing , Li Ping , Cao Di , Zheng Yong-qiu 
Published: October 2021

Background: Accumulating evidence suggests that the polymerase I and transcript release factor (PTRF), a key component of the caveolae structure on the plasma membrane, plays a pivotal role in suppressing the progression of colorectal cancers. However, the role of PTRF in the development of functional gastrointestinal (GI) disorders remains unclear. Post-infectious irritable bowel syndrome (PI-IBS) is a common functional GI disorder that occurs after an acute GI infection. Here, we focused on the role of PTRF in the occurrence of PI-IBS and investigated the underlying mechanisms.Methods: Lipopolysaccharide (LPS) (5 μg/ml) was used to induce inflammatory injury in human primary colonic epithelial cells (HCoEpiCs). Furthermore, a rat model of PI-IBS was used to study the role of PTRF. Intestinal sensitivity was assessed based on the fecal water content. A two-bottle sucrose intake test was used to evaluate behavioral changes. Furthermore, shRNA-mediated knockdown of PTRF was performed both in vitro and in vivo. We detected the expression of PTRF in colonic mucosal tissues through immunohistochemistry (IHC), western blotting (WB), and immunofluorescence (IF) analysis. Luciferase activity was quantified using a luciferase assay. Co-localization of PTRF and Toll-like receptor 4 (TLR4) was detected using IF analysis. The activation of the signaling pathways downstream of TLR4, including the iNOs, p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) pathways, was detected via WB. The levels of NO, IL-1β, IL-6, and TNF-α were measured using enzyme-linked immunosorbent assays.Results: LPS significantly induced PTRF expression and signaling downstream of TLR4, including p38, ERK, and JNK pathways, in HCoEpiCs. Moreover, shRNA-mediated knockdown of PTRF in HCoEpiCs significantly decreased the phosphorylation of JNK, ERK, and p38 and iNOS expression. In PI-IBS rats, the lack of PTRF not only reduced fecal water content and suppressed depressive behavior but also increased the body weight. Furthermore, we found a strong co-localization pattern for PTRF and TLR4. Consistently, the lack of PTRF impaired TLR4 signaling, as shown by the decreased levels of p-JNK, p-ERK, and p-p38, which are upstream factors involved in iNOS expression.Conclusion: PTRF promoted PI-IBS and stimulated TLR4 signaling both in vitro and in vivo. The results of this study not only enlighten the pathogenesis of PI-IBS but also help us understand the biological activity of PTRF and provide an important basis for the clinical treatment of PI-IBS by targeting PTRF.
Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies
Authors: Ting Darren Shu Jeng , Li Jianguo , Verma Chandra S. , Goh Eunice T. L. , Nubile Mario , Mastropasqua Leonardo , Said Dalia G. , Beuerman Roger W. , Lakshminarayanan Rajamani , Mohammed Imran , Dua Harminder S. 
Published: October 2021

Background/Aim: Host defense peptides (HDPs) have the potential to provide a novel solution to antimicrobial resistance (AMR) in view of their unique and broad-spectrum antimicrobial activities. We had recently developed a novel hybrid HDP based on LL-37 and human beta-defensin-2, named CaD23, which was shown to exhibit good in vivo antimicrobial efficacy against Staphylococcus aureus in a bacterial keratitis murine model. This study aimed to examine the potential CaD23-antibiotic synergism and the secondary structure and underlying mechanism of action of CaD23.Methods: Peptide-antibiotic interaction was evaluated against S. aureus, methicillin-resistant S. aureus (MRSA), and Pseudomonas aeruginosa using established checkerboard and time-kill assays. Fractional inhibitory concentration index (FICI) was calculated and interpreted as synergistic (FIC&lt;0.5), additive (FIC between 0.5–1.0), indifferent (FIC between &gt;1.0 and ≤4), or antagonistic (FIC&gt;4). SYTOX green uptake assay was performed to determine the membrane-permeabilising action of CaD23. Molecular dynamics (MD) simulations were performed to evaluate the interaction of CaD23 with bacterial and mammalian mimetic membranes. Circular dichroism (CD) spectroscopy was also performed to examine the secondary structures of CaD23.Results: CaD23-amikacin and CaD23-levofloxacin combination treatment exhibited a strong additive effect against S. aureus SH1000 (FICI = 0.60–0.69) and MRSA43300 (FICI = 0.56–0.60) but an indifferent effect against P. aeruginosa (FIC = 1.03–1.15). CaD23 (at 25 μg/ml; 2xMIC) completely killed S. aureus within 30 min. When used at sub-MIC concentration (3.1 μg/ml; 0.25xMIC), it was able to expedite the antimicrobial action of amikacin against S. aureus by 50%. The rapid antimicrobial action of CaD23 was attributed to the underlying membrane-permeabilising mechanism of action, evidenced by the SYTOX green uptake assay and MD simulations studies. MD simulations revealed that cationicity, alpha-helicity, amphiphilicity and hydrophobicity (related to the Trp residue at C-terminal) play important roles in the antimicrobial action of CaD23. The secondary structures of CaD23 observed in MD simulations were validated by CD spectroscopy.Conclusion: CaD23 is a novel alpha-helical, membrane-active synthetic HDP that can enhance and expedite the antimicrobial action of antibiotics against Gram-positive bacteria when used in combination. MD simulations serves as a powerful tool in revealing the peptide secondary structure, dissecting the mechanism of action, and guiding the design and optimisation of HDPs.
Emotional Processing and Its Association to Somatic Symptom Change in Emotional Awareness and Expression Therapy for Somatic Symptom Disorder: A Preliminary Mediation Investigation
Authors: Maroti Daniel , Ljótsson Brjánn , Lumley Mark A. , Schubiner Howard , Hallberg Henrik , Olsson Per-Åke , Johansson Robert 
Published: October 2021

Objective: The aim of this study was to investigate emotional processing as a potential mediator in therapist-guided, internet-based Emotional Awareness and Expression Therapy (I-EAET) for somatic symptom disorder, using data from a previously published pilot study.Methods: Participants (N = 52) engaged in a 9-week I-EAET treatment. Before treatment and each week during treatment (i.e., 10 weekly measurements), emotional processing was assessed with the Emotional Processing Scale-25 (EPS-25), which contains five subscales, and somatic symptoms were assessed with the Patient Health Questionnaire-15 (PHQ-15).Results: Mediation analyses using linear mixed models showed that two EPS-25 subscales—Signs of Unprocessed Emotions and Impoverished Emotional Experience—were uniquely associated with somatic symptom reduction. The proportion of the mediated effect was 0.49, indicating that about half of the total association of the PHQ-15 with symptoms was accounted for by the two EPS-25 subscales.Conclusion: This preliminary mediation analysis suggests that improved emotional processing is associated with change in somatic symptoms in I-EAET. However, randomized controlled and comparison trials are needed to establish that I-EAET creates the change in emotional processing and that such changes are specific to I-EAET.
A Novel Matrix Profile-Guided Attention LSTM Model for Forecasting COVID-19 Cases in USA
Authors: Liu Qian , Fung Daryl L. X. , Lac Leann , Hu Pingzhao 
Published: October 2021

Background: The outbreak of the novel coronavirus disease 2019 (COVID-19) has been raging around the world for more than 1 year. Analysis of previous COVID-19 data is useful to explore its epidemic patterns. Utilizing data mining and machine learning methods for COVID-19 forecasting might provide a better insight into the trends of COVID-19 cases. This study aims to model the COVID-19 cases and perform forecasting of three important indicators of COVID-19 in the United States of America (USA), which are the adjusted percentage of daily admitted hospitalized COVID-19 cases (hospital admission), the number of daily confirmed COVID-19 cases (confirmed cases), and the number of daily death cases caused by COVID-19 (death cases).Materials and Methods: The actual COVID-19 data from March 1, 2020 to August 5, 2021 were obtained from Carnegie Mellon University Delphi Research Group. A novel forecasting algorithm was proposed to model and predict the three indicators. This algorithm is a hybrid of an unsupervised time series anomaly detection technique called matrix profile and an attention-based long short-term memory (LSTM) model. Several classic statistical models and the baseline recurrent neural network (RNN) models were used as the baseline models. All models were evaluated using a repeated holdout training and test strategy.Results: The proposed matrix profile-assisted attention-based LSTM model performed the best among all the compared models, which has the root mean square error (RMSE) = 1.23, 31612.81, 467.17, mean absolute error (MAE) = 0.95, 26259.55, 364.02, and mean absolute percentage error (MAPE) = 0.25, 1.06, 0.55, for hospital admission, confirmed cases, and death cases, respectively.Conclusion: The proposed model is more powerful in forecasting COVID-19 cases. It can potentially aid policymakers in making prevention plans and guide health care managers to allocate health care resources reasonably.
English Language for Refugees at Higher Education
Authors: Faruk Ipek Omer 
Published: October 2021

After the massive immigration caused by the war in middle east, English language filled the communicationgap between the people of host counties and refugees. Framing the study with language learning for resilience, in this qualitative case study, the status of refugee students at a Turkish higher education foreign language institution has been investigated to find out: (a) educational background of refugee students, (b)refugees’ current state of language learning for resilience, and (c) instructors’ positions on English education for resilience.Two Iraqi, one Syrian refugee students and their two language teachers participated in this study. Tocollect data, semi-structured interviews were conducted. The results showed us that although these students are coming from different educational backgrounds, they hold similar beliefs about English education and have hopes for their future. It is implied that with special and intensive assistance, being competent in English language will open the gates to global opportunities for refugees.
Covid 19 and Indian Healthcare System: Are We Really Ready to Face the Global Pandemic
Authors: Kumar Saurav 
Published: October 2021

The COVID-19 pandemic is worldwide wellbeing and financial emergency of a scale never saw. Starting in China, it has, inside a couple of months, crushed numerous nations throughout the planet, requiring an uncommon assembly of wellbeing frameworks. While the infection brought about by this novel infection is, for the most part, gentle and self-restricting, the danger of serious illness is lopsidedly great among old and those with basic ailments. Without an antibody or treatment, the general wellbeing techniques include: (a) forestalling transmission through early discovery and separation, following contacts and isolating them and execution of measures, for example, social removing and hand cleanliness and (b) decreasing mortality by enlarging clinical administration and protecting the weakest populaces in the general public. The pandemic is one more update. We need to put resources into general wellbeing, increase public abilities to recognize an illness early and react quickly to arising contaminations, fortify and regard our public establishments and depend on proof base for policymaking. Ample opportunity has already passed that we paid regard to these exercises and fortified immediately our wellbeing framework limit, as plagues and pandemics of this nature will keep on general testing wellbeing great into what’s to come. This paper attempts to comprehend the various parts of monetary difficulties looked at by the Indian medical services framework and devise the potential measures to beat the impact of the COVID-19 pandemic in India. It investigations the present moment and conceivable long haul effect of this pandemic on the medical services area of India as far as productivity and value.
The Impact of Covid 19 on Job Security and Psychological Wellbeing among Textile Employees in Tiruppur District
Authors: Uma R , Balakrishnan K P 
Published: October 2021

The purpose of the study is to examine the impact of the pandemic situation created by Covid 19 on job security and the subsequent effect it has on the psychological wellbeing of employees in the Textile Industry in the Tiruppur district of Tamilnadu. Job security is an important factor for promoting employee job satisfaction and is also associated with employee physical and mental health. Hence there is a need to examine the impact of Covid 19 on job security and the psychological wellbeing of employees. The respondents for the study include supervisory staff and the sample size is 104, collected by convenience sampling method. Data were analysed using SPSS and the statistical techniques employed are correlation and regression. The results have confirmed the employee concern with job security factors due to Covid 19 having a significant impact on their psychological well-being.
Ethnobotany, Phytochemistry, and Pharmacological Efficacy of Bixaorellana: A Review
Authors: Purushothaman T , Irfanamol K 
Published: October 2021

Bixa Orellana, commonly known as lipstick tree, is a small perennial tree with reddish triangular fruits. It is commonly utilised as a natural dye, which found a wide range of applications in both foods and textile industries. It is also used in traditional medicinal practices to treating various health ailments. This review aims to summarise the ethnobotanical, phytochemistry as well as the pharmacological potential of Bixa Orellana. It has been used for fever, skin problems, intestinal problems, and hepatoprotection by the various tribal communities worldwide. It is also employed as an antidote to bites and as an insect repellant. The phytochemical review demonstrated numerous bioactive compounds such as alkaloids, tannins, terpenoids, saponins, flavonoids, etc. The pharmacological investigations evidenced that the plant has excellent antimicrobial, antipyretic, antidiabetic, anticonvulsant, antioxidant, and anticancer properties. In addition, Bixa Orellana can be used as a photosensitiser in antimicrobial photodynamic inactivation therapy to eliminate micro-organisms. So, the pieces of evidence highlighted in this review will be helpful insights for further scientific studies for the discovery and development of novel therapeutic agents.
Wooden Toy of Chennapatna, India: Beauty of Form & Socio-Cultural Reflection on the Characterization of Toy
Authors: Biswas Pradipta 
Published: October 2021

Toy making is a part of almost every civilisation, and still, it is continuing as a living tradition in so many countries. Toys play an overall growth for a child. It developed a child mentally, physically, socially, and emotionally. Though it has started as a folk tradition or community-based craft, it has commercial and strong aesthetical value. This study focused on the Chennapatna toy from India. Chennapatna toy is a environment-friendly toy made with softwood, natural colour, and lacquer. This study critically analyses the beauty of the form of Chennapatna toys and also explore how this toy is made by natural substance. Like other art forms, toys also represent art, culture, religion, society, and civilisation. This study also critically analyses the socio-cultural issues, which are well reflected through this toy-making tradition.
Application of Emoji on Social Media: its Impact among Youngsters
Authors: Chitra V , Swaranalatha R 
Published: October 2021

The growth of communication shows a tremendous rise in today’s environment. The latest and shortest form of communication tool used in social media is Emoji. Emoji’s express the emotions of the user while in communication. This paper focuses on the use of Emoji on social media such as Facebook, Whatsapp and Instagram. The study results show that most of the users use Emoji’s to save time and for an easy way of communicating their thought to the receiver.
Paradigm Shift in School Curriculum: Need of the Hour
Authors: Saroh Tayum 
Published: October 2021

The school curriculum has to be analyzed occasionally to create a scope to encompass new disciplines and areas to make the curriculum appropriate to the prevailing situation. The conventional curriculum sometimes becomes obsolete and desires substitute to offer scope for new areas to be included in the curriculum. The effectiveness of a curriculum depends on how lots the curriculum is fulfilling the social needs and the educational objectives. Our generation has the right to explore new disciplines and areas through the updated curriculum in education. This paper offers the inclusion of environmental education rationalization of education, human rights education, and health education as part of a paradigm shift in school curriculum primarily based on the need of the hour.
Research Trends in Diabetes Applying VOS Viewer: A Scientometric Profile
Authors: Catherin Beula C , Velmurugan Chandran 
Published: October 2021

As diabetes is a non-communicable disease, many scientists try to cure it in different ways throughout the globe. Due to the remarkable scientific growth in this area, we focus on evaluating the scholarly publications and their current research trends in diabetes, particularly type 1 diabetes published by Indian scientists using statistical tools and scientometric analysis. A total of 83 318 global research productivity and a total number of research publications from India was 2 381 with 36, 408 global citations and the Period between 2009 and 2018. Further, the total number of authors (17712) and its average number of authors is 7.44, a total number of 782 core journals and 95 228 cited references found during the research period. To evaluate data, various scientometric techniques or indicators were used such as Authorship Pattern (Single vs Multiple), Degree of Collaboration, Relative growth rate (RGR) and Doubling Time (DT) and many more indicators used. This study limits with Indian research output did not include world literature. We try to identify the information in different types of type 1 diabetes between 2009 and 2018. This study will help to find out the core journals for collection management and for promoting diabetes research and developments in future. We chose the core keywords in type 1 diabetes with full records with abstracts, types of manuscripts, cited references using the Web of Science database.