bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric psoriasis induced by HLA‐B46‐Cw1 haplotype: A retrospective study of psoriasis onset after hematopoietic stem cell transplantation
Authors: Terui Hitoshi , Yamasaki Kenshi , Hagiwara‐Takita Akiko , Shimada‐Omori Ryoko , Tsuchiyama Kenichiro , Saito‐Nanjo Yuka , Rikiishi Takeshi , Sasahara Yoji , Aiba Setsuya 
Published: May 2021

AbstractGenome‐wide association studies have identified more than 60 susceptibility loci for psoriasis, highlighting the role of genetics in psoriasis development. Although the HLA region is suggested as the most prominent susceptibility locus, the role of the HLA haplotype in the development of psoriasis is unclear. The aim of this study is to investigate how HLA haplotype changes affect the onset of psoriasis and which HLA haplotypes are associated with the development of psoriasis. A longitudinal, retrospective case series study of children was conducted at Tohoku University Hospital in Japan, between November 1981 and October 2020. We evaluated a total of 378 pediatric patients who underwent hematopoietic stem cell transplantation in the Department of Pediatrics. The background of these patients and their HLA haplotypes before and after transplantation was assessed. Among the 378 cases, aged 0–22 years old (median age 6) identified, 117 cases received autologous transplantation, 260 cases received allogeneic transplantation, and one case received syngeneic transplantation. Only two cases developed de novo psoriasis, and these cases had acquired HLA‐B46‐Cw1 after allogeneic transplantation. Others who had HLA‐B46‐Cw1 before and after allogeneic transplantation did not develop psoriasis. Our findings suggest that the HLA‐B46 and HLA‐Cw1 combination contributes to the development of psoriasis in this Asian population.
Sudden death due to cardiac contusion: Forensic implications in a rare pediatric case
Authors: Gentile Guendalina , Tambuzzi Stefano , Giovanetti Giulio , Zoja Riccardo 
Published: May 2021

AbstractBlunt chest trauma (BCT) often results in blunt cardiac injuries of little clinical concern, but cases of severe heart damage with high mortality rates have also been described. In particular, BCT should never be underestimated, especially when it is located in the anterior thoracic region. Among traffic accidents, motorcyclists are the most vulnerable and at the greatest risk. We report the case of a 14‐year‐old boy who experienced BCT following a motorcycle accident. He was evaluated at the hospital and was found to be in good medical condition, without bruises or rib fractures. Electrocardiography revealed a left bundle branch block. The patient was kept overnight for observation and was discharged the following morning in a good health condition. However, five days later, the patient suddenly died. Autopsy revealed a cardiac contusion associated with a full‐thickness myocardial rupture and massive hemopericardium. Histologically, hemorrhagic infiltration foci, fibrin deposits, neutrophilic granulocytes, and well‐defined areas of necrosis were detected in the context of recent fibrosis. Coronary thrombosis was not observed. The cause of death was identified as cardiac contusion that caused myocardial necrosis and, ultimately, cardiac rupture. Because the boy suffered a recent BCT and was assessed at the hospital, issues of medical malpractice were raised. This case demonstrates the potential lethality of blunt chest trauma in pediatric patients and demonstrates the importance of not underestimating such events, even in the absence of clinically identified chest injuries.
Employees perceptions of non‐monetary recognition practice and turnover: Does recognition source alignment and contrast matter?
Authors: Chênevert Denis , Hill Kevin , Kilroy Steven 
Published: May 2021

AbstractNonmonetary recognition originates from various sources (distal and proximal) and research has yet to examine the interplay among them. Results of a 2‐year time‐lagged study (N = 221), employing polynomial regression and response surface analysis, revealed that when distal organisational nonmonetary recognition is aligned with recognition from proximal sources, employees had lower turnover intentions and, indirectly, were less likely to quit 2 years later. For the most part, these relationships do not differ significantly based on the level at which alignment of distal and proximal recognition occurs. In terms of contrasts, when distal recognition exceeds the level of proximal recognition from the supervisor, turnover intentions are higher. For other proximal sources (co‐workers, physicians and patients), turnover intentions were higher irrespective of the type of contrast. This study adds to the strategic HRM literature by showing that contrasts between distal and proximal recognition undermine HR practice perception and employees' organisational attachment.
Improvements in radiation therapy services in Myanmar: 2012–2020
Authors: Opie Craig , Shwe Kaung Myat 
Published: May 2021

AbstractIntroductionMyanmar is a Low‐Middle Income Country (LMIC) in South‐East Asia. Over the last decade, reforms to the health system have included significant improvements in the delivery of radiation therapy services in both government and private‐for‐profit sectors.MethodsThis review uses limited cancer registry data, observations from in‐person visits, and data from key informants in Myanmar radiation therapy centres, to report on developments in radiation therapy services in recent years.ResultsRising national cancer incidence estimates presented in this article are supplemented with annual cancer case and radiation therapy course completion statistics from three hospital / regional contexts. Strategies which enabled the increased delivery of radiation therapy services are described. Data regarding the geographic locations of radiation therapy centres, their equipment and software inventories, is tabulated. The impact on clinical practice standards through upgraded equipment and software used for treatment planning and delivery is discussed. Clinical staffing at each centre is catalogued, role descriptions are given, and increases in staff numbers in recent years are documented. The present clinical and academic education challenges for radiation therapy staff and the importance of these issues for technical practice advancements are discussed.ConclusionMyanmar’s successes and continued challenges in radiation therapy service delivery are emulated in other LMIC’s. Strategic planning for new and existing radiation therapy centres, further staff increases and improved academic and clinical learning for radiation therapy staff should assist in meeting these challenges. Further international engagement could also enhance these processes.
Primary ciliated muconodular papillary tumor: A rare pulmonary disease and literature review of 65 cases
Authors: Wang Yanye , Wang Dan , Wang Jun , Zhao Shikang , Ren Dian , Chen Gang , Wang Qiuhui , Xu Dongbo , Xu Song 
Published: May 2021

AbstractA ciliated muconodular papillary tumor (CMPT) or bronchiolar adenoma (BA) is a rather rare and unique type of lung tumor characterized by tripartite cellular components with a papillary‐predominant structure including ciliated columnar cells, mucinous cells, and basal cells. Here, we present the case of a 64‐year‐old woman who was diagnosed with CMPT in our center. In addition to reporting the clinicopathological characteristics of this case, we also conducted whole exome sequencing (WES) to explore the underlying mechanism. According to current evidence, CMPTs tends to be benign or of low grade malignancy. However, this requires further validation.
5‐HT6R null mutatrion induces synaptic and cognitive defects
Authors: Sun Zehui , Wang Bingjie , Chen Chen , Li Chenjian , Zhang Yan 
Published: May 2021

AbstractSerotonin 6 receptor (5‐HT6R) is a promising target for a variety of human diseases, such as Alzheimer's disease (AD) and schizophrenia. However, the detailed mechanism underlying 5‐HT6R activity in the central nervous system (CNS) is not fully understood. In the present study, 5‐HT6R null mutant (5‐HT6R−/−) mice were found to exhibit cognitive deficiencies and abnormal anxiety levels. 5‐HT6R is considered to be specifically localized on the primary cilia. We found that the loss of 5‐HT6R affected the Sonic Hedgehog signaling pathway in the primary cilia. 5‐HT6R−/− mice showed remarkable alterations in neuronal morphology, including dendrite complexity and axon initial segment morphology. Neurons lacking 5‐HT6R exhibited increased neuronal excitability. Our findings highlight the complexity of 5‐HT6R functions in the primary ciliary and neuronal physiology, supporting the theory that this receptor modulates neuronal morphology and transmission, and contributes to cognitive deficits in a variety of human diseases, such as AD, schizophrenia, and ciliopathies.
Persistent dependent behaviour is accompanied by dynamic switching between the ventral and dorsal striatal connections in internet gaming disorder
Authors: Wang Min , Zheng Hui , Zhou Weiran , Jiang Qing , Dong Guang‐Heng 
Published: May 2021

AbstractCross‐sectional studies have suggested that functional heterogeneity within the striatum in individuals with addictive behaviours may involve the transition from ventral to dorsal partitions; however, due to limitations of the cross‐sectional design, whether the contribution of this transition to addiction was confused by individual differences remains unclear, especially for internet gaming disorder (IGD). Longitudinal functional magnetic resonance imaging (fMRI) data from 22 IGD subjects and 18 healthy controls were collected at baseline and more than 6 months later. We examined the connectivity features of subregions within the striatum between these two scans. Based on the results, we further performed dynamic causal modelling to explore the directional effect between regions and used these key features for data classification in machine learning to test the replicability of the results. Compared with controls, IGD subjects exhibited decreased functional connectivity between the left dorsal striatum (putamen) and the left insula, whereas connectivity between the right ventral striatum (nucleus accumbens [Nacc]) and the left insula was relatively stable over time. An inhibitory effective connectivity from the left putamen to the right Nacc was found in IGD subjects during the follow‐up scan. Using the above features, the classification accuracy of the training model developed with the follow‐up was better than that of the model based on the initial scan. Persistent IGD status was accompanied by a switch in the locus of control within the striatum, which provided new insights into association between IGD and drug addiction.
Plant functional traits explain species abundance patterns and strategies shifts among saplings and adult trees in Araucaria forests
Authors: Klipel Joice , Bergamin Rodrigo Scarton , Seger Guilherme Dubal Dos Santos , Carlucci Marcos Bergmann , Müller Sandra Cristina 
Published: May 2021

AbstractSpecies‐rich communities are composed of several locally rare and a few abundant species. A trait‐based approach can derive general explanations for such species abundance distribution. However, for tree species in forests, the intraspecific variation of traits associated with the ontogeny and understory/canopy conditions must be considered. Here, we quantified intraspecific variation of leaf traits across saplings and adults in trees and tested if leaf and/or regenerative traits mediate the species abundance distribution of saplings and adults, and if saplings abundance also determines the abundance of adults in tree communities of Araucaria forests in Southern Brazil. We found intraspecific variation for specific leaf area (SLA) and leaf dry matter content (LDMC), but not for leaf area (LA). Adults have higher LDMC and lower SLA than saplings, suggesting a shift in investment strategies. Species abundant in saplings were associated with larger LA, whereas abundant species in the adults had lower SLA and LA and a larger number of seeds per fruit. The abundance of saplings also contributed to explaining the abundance of species as adults. Saplings experience low light availability in the understory, larger leaves are essential to maximising light capture. On the other hand, adult trees face high irradiation, windy and frost exposure conditions; species with lower SLA reach higher abundance. Regenerative traits were only relevant for the model of adults. Species abundance distribution in forests is related to functional traits, but the relationship is distinct for saplings and adults as leaf traits vary according to the ontogenetic stage and/or the environmental conditions imposed to individuals. In addition, we suggest the assembly of trees in the upper forest stratum is not only mediated by abiotic and biotic filters that favour some leaf and regenerative attributes, but also by lasting effects of variables that filtered out individuals in former development stages.
The effect of peri‐operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non‐cardiac surgical patients: a randomised, double‐blind placebo‐controlled trial
Authors: van Norden J. , Spies C. D. , Borchers F. , Mertens M. , Kurth J. , Heidgen J. , Pohrt A. , Mueller A. 
Published: May 2021

SummaryDelirium occurs commonly following major non‐cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive dysfunction; increased length of hospital stay; and major postoperative complications and morbidity. The aim of this study was to investigate the effect of peri‐operative administration of dexmedetomidine on the incidence of postoperative delirium in non‐cardiac and cardiac surgical patients. In this randomised, double‐blind placebo‐controlled trial we included 63 patients aged ≥ 60 years undergoing major open abdominal surgery or coronary artery bypass graft surgery with cardiopulmonary bypass. The primary outcome was the incidence of postoperative delirium, as screened for with the Confusion Assessment Method. Delirium assessment was performed twice daily until postoperative day 5, at the time of discharge from hospital or until postoperative day 14. We found that dexmedetomidine was associated with a reduced incidence of postoperative delirium within the first 5 postoperative days, 43.8% vs. 17.9%, p = 0.038. Severity of delirium, screened with the Intensive Care Delirium Screening Checklist, was comparable in both groups, with a mean maximum score of 1.54 vs. 1.68, p = 0.767. No patients in the dexmedetomidine group died while five (15.6%) patients in the placebo group died, p = 0.029. For patients aged ≥ 60 years undergoing major cardiac or non‐cardiac surgery, we conclude that the peri‐operative administration of dexmedetomidine is associated with a lower incidence of postoperative delirium.
Infill asymptotics for adaptive kernel estimators of spatial intensity
Authors: van Lieshout M.N.M. 
Published: May 2021

SummaryWe apply the Abramson principle to define adaptive kernel estimators for the intensity function of a spatial point process. We derive asymptotic expansions for the bias and variance under the regime thatnindependent copies of a simple point process in Euclidean space are superposed. The method is illustrated by means of a simple example and applied to tornado data.
Depth and outliers for samples of sets and random sets distributions
Authors: Cascos Ignacio , Li Qiyu , Molchanov Ilya 
Published: May 2021

SummaryWe suggest several constructions suitable to define the depth of set‐valued observations with respect to a sample of convex sets or with respect to the distribution of a random closed convex set. With the concept of a depth, it is possible to determine if a given convex set should be regarded an outlier with respect to a sample of convex closed sets. Some of our constructions are motivated by the known concepts of half‐space depth and band depth for function‐valued data. A novel construction derives the depth from a family of non‐linear expectations of random sets. Furthermore, we address the role of positions of sets for evaluation of their depth. Two case studies concern interval regression for Greek wine data and detection of outliers in a sample of particles.
Exploring vaccination practices of midwives in British Columbia
Authors: Bettinger Julie A. , Rubincam Clara , Greyson Devon , Weissinger Sandra , Naus Monika 
Published: May 2021

AbstractBackgroundRegistered midwives in British Columbia (BC) are primary health care practitioners for healthy people throughout pregnancy and for approximately 6 weeks postpartum. BC registered midwives are authorized to prescribe and administer certain vaccines to adults under their care during the perinatal period and hepatitis B vaccine to high‐risk newborns. However, little has been documented about their recommendations for, and administration of, prenatal and infant vaccinations. This study surveyed midwives currently practicing in British Columbia to understand their vaccination practices.MethodsAn online survey was administered to the members of the Midwives Association of BC in spring 2018. Outcome measures were the proportion of midwives who discussed, recommended, and administered the following vaccines: influenza, varicella, rubella, and infant hepatitis B. The proportion of midwives who discussed and recommended infant vaccines was measured. Barriers to discussion, recommendation, and administration of vaccines were captured.ResultsSixty‐three percent of 108 respondents administered vaccines to their clients. Hepatitis B and rubella were the most frequent vaccines administered. Logistical concerns were the greatest barrier to vaccine administration. This was followed by the perception that vaccine administration is not within the scope of practice of midwives, especially for influenza vaccine. Midwives who administered vaccines were significantly more likely to discuss and recommend vaccines to their clients and their infants.ConclusionsThe majority of BC midwives discuss, recommend, and administer vaccines to their clients. Our survey highlighted key areas to address to strengthen midwifery capacity to discuss, recommend, and provide prenatal and infant vaccines.
Staying on target: A systematic literature review on learner‐facing learning analytics dashboards
Authors: Valle Natercia , Antonenko Pavlo , Dawson Kara , Huggins‐Manley Anne Corinne 
Published: May 2021

AbstractThe advances in technology to capture and process unprecedented amounts of educational data has boosted the interest in Learning Analytics Dashboard (LAD) applications as a way to provide meaningful visual information to administrators, parents, teachers and learners. Despite the frequent argument that LADs are useful to support target users and their goals to monitor and act upon the information provided, little is known about LADs’ theoretical underpinnings and the alignment (or lack thereof) between LADs intended outcomes and the measures used to evaluate their implementation. However, this knowledge is necessary to illuminate more efficient approaches in the development and implementation of LAD tools. Guided by the self‐regulated learning perspective and using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) framework, this systematic literature review addressed this gap by examining whether and how learner‐facing LAD’s target outcomes align with the domain measures used to evaluate their implementations. Out of the 1297 papers retrieved from 15 databases, 28 were included in the final quantitative and qualitative analysis. Results suggested an intriguing lack of alignment between LADs’ intended outcomes (mostly cognitive domain) and their evaluation (mostly affective measures). Based on these results and on the premise that LADs are designed to support learners, a critical recommendation from this study is that LADs’ target outcomes should guide the selection of measures used to evaluate the efficacy of these tools. This alignment is critical to enable the construction of more robust guidelines to inform future endeavours in the field.
Practitioner notesWhat is already known about this topic

There has been an increased interest and investment in learning analytics dashboards to support learners as end‐users.
Learner‐facing learning analytics dashboards are designed with different purposes, functionalities and types of data in an attempt to influence learners’ behaviour, achievement and skills.
What this paper adds

This paper reports trends and opportunities regarding the design of learner‐facing learning analytics dashboards, contexts of implementation, as well as types and features of learner‐facing learning analytics dashboard studies.
The paper discusses how affect and motivation have been largely overlooked as target outcomes in learner‐facing learning analytics dashboards.
Implications for practice and/or policy

Based on the evidence gathered through the review, this paper makes recommendations for theory (eg, inclusion of motivation as an important target outcome).
The paper makes recommendations related to the design, implementation and evaluation of learning analytics dashboards.
The paper also highlights the need for further integration between learner‐facing learning analytics dashboards and open learner models.
Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: overactivated WNT/β‐catenin signalling by parallel RNA sequencing and dysfunctional phenotypes
Authors: Xu Ruohao , Huang Xin , Li Chao , Deng Chengxin , Li Minming , Wu Ping , Geng Suxia , Lai Peilong , Lu Zesheng , Weng Jianyu , Du Xin 
Published: May 2021

SummarySophisticated cross‐talk between bone marrow mesenchymal stromal cells (BM MSCs) and haematopoietic/leukaemic stem cells in patients with myelodysplastic syndromes (MDS) and myeloid leukaemia have been emphasized in previous reports. However, mesenchymal elements in patients with chronic myelomonocytic leukaemia (CMML) were poorly investigated. By utilizing a parallel RNA‐sequencing method, we investigated the transcriptional profile and functional defects of primary BM MSCs from patients with CMML for the first time. Within a 24‐patient cohort, transcriptional and functional analysis reveals a prominent enrichment of WNT/β‐catenin signalling and multiple biology processes. Deregulated expression of WNT/β‐catnin factors CTNNB1, CMYC, LEF1, and FRZB is associated with impaired proliferation, senescence phenotype, and abnormal secretion in CMML MSCs. The impaired ability to support healthy CD34+ haematopoietic stem and progenitor cells (HSPCs) correlates with activation of WNT/β‐catenin signalling in CMML MSCs. Furthermore, we observed an association between WNT/β‐catenin factors and treatment response to hypomethylating agents (HMAs) in a cohort of patients with MDS/myeloproliferative neoplasms (MPNs). Taken together, our study provides evidence for transcriptional and functional abnormalities in CMML MSCs, and suggests potential prognostic value of evaluating WNT/β‐catenin signalling in patients with CMML.