bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric study on papillary muscles of human tricuspid valve-dissection method
Authors: Chandragirish S  , Harsha B R  , Patil Girish V 
Published: October 2021

Aim of the present study was to observe the measurements of anterior papillary muscles present in tricuspid valve of human heart. Measurements of anterior papillary muscles in tricuspid valve gains utmost importance in cardiac surgeries because they are the causes of myocardial infarction in recent times because of its variations and detection of these causes by advent in modern technologies which will help in treatment of tricuspid valve diseases. This study was carried out on 96 normal formalin fixed human heart specimens. Dissection was performed according to standard techniques. Anterior papillary muscles were observed and length, width and thickness of each muscle were measured and documented. In the present study, numbers of anterior papillary muscles were present with a frequency of 1-3, with most common appearance of 1 muscle in 66 hearts (68.8%) and least common incidence of 3 muscles in 6 hearts (6.3%). Anterior papillary muscles were present in all 96 hearts. In measurements, anterior papillary muscles mean height was 1.49±0.44 cm; mean width was 0.82±0.21 cm and mean thickness was 0.64±0.15 cm respectively. We hope this study will serve to understand the morphometry of anterior papillary muscles better and will help in various surgical procedures and cardiac treatment done on tricuspid valve.
Morphometric study of upper end of tibia and its implications in total knee replacement
Authors: Akhtar Md. Jawed , Reeti Raag , Kumar Binod , Sinha Rajiv Ranjan , Kumar Avanish 
Published: October 2021

: Knee deformities can be reliably assessed by using morphometric parameters of upper end of tibia. Total knee arthroplasties are done to treat many types of arthritis and injuries involving knee joint. So, there is a need to have data of various morphometric parameters of upper end of tibia in order to have better surgical outcomes. The present study was attempted to provide values of different parameters in the population of Bihar.: The present study was a cross-sectional and prospective study conducted on 50 tibia of unknown gender and age in the Department of Anatomy, Indira Gandhi Institute of Medical Sciences, Patna. Fully ossified, dried, macerated and thoroughly cleaned tibia were taken to measure different parameters of upper end with the help of digital vernier calliper. The data thus obtained were tabulated and analysed statistically using Microsoft excel software.: It was found that the diameters of medial condyle were more than the lateral condyle. The antero-posterior diameter was more than the transverse diameter in case of both the condyles. But the difference between the right and the left side was not statistically significant.: The present study will help in providing a baseline data for designing of the prosthesis used in total knee replacement surgeries. It will also be helpful to anthropologists and forensic experts.
Study of QT interval prolongation in asymptomatic type-2 diabetes mellitus patients with and without microalbuninuria
Authors: Mustafa Farzana , Mohammed Abdul Hai 
Published: October 2021

QT interval abnormalities are the best predictors of cardiovascular deaths. Microalbuminuria is an independent marker for cardiovascular disease in diabetes mellitus. Hence QT interval abnormalities in diabetics with or without microalbuminuria were evaluated in this study. To study QT interval abnormalities in asymptomatic type 2 diabetic patients with or without microalbuminuria. : Open label controlled study with 214 subjects of either sex. Group A healthy subjects (n=100), group B asymptomatic, type 2 diabetics with no clinical evidence of cardiac disease. Group B subdivided into B with microalbuminuria (n=62), Bwithout microalbuminuria (n=52). Corrected QT interval (QTC), microalbuminuria, and blood pressure were measured for all subjects. QTC was calculated by using Bazzet's formula. QTC more than 440msec was considered prolonged. QTC was within normal range in diabetic patients(415+25msec). Highly significant (p&#60;0.0001) prolongation was observed in diabetics, compared to healthy subjects. Both B(p&#60;0.0001) and B(p&#60;0.001) groups showed a significant increase in QTC than in healthy subjects. Among Band Bgroups QTC was not statistically significant. Prolongation of QTC is indicative of CAN. CAN is often under-recognised and undiagnosed cardiac complication.QTC was more in asymptomatic type 2 diabetics irrespective of microalbuminuria compared to healthy individuals, though values were within normal range. This denotes high risk for future cardiovascular complications in diabetic patients.
IMBALANCE OF ANTIOXIDANT-PROOXIDANT SYSTEM IN RAT'S JAW BONE TISSUE UNDER LONG-TERM INTRODUCTION OF ETHANOL
Authors: Makarenko О. А. , Kika V. V. , Mudrik L. M. 
Published: October 2021

Introduction. Nowadays, it is unclear what the trigger for bone resorption under the influence of chronic alcohol consumption is. As the reactions of conversion of ethanol into acetic acid are accompanied by an increase in the production of reactive oxygen species, it can be assumed that the formation of oxidative stress with prolonged alcohol consumption occurs in bone tissue as well.
Aim. Research of the effect of chronic administration of ethanol to females and males laboratory rats on indices of resorption, osteogenesis, the condition of the antioxidant-prooxidant system in bone tissue.
Materials and Methods. 2-month old animals received from 5 % to 15 % of ethanol in their drinking water with gradual increase of the concentration. The lower jaws were segregated, and the degree of atrophy of the alveolar process was calculated. The activity of elastase, acidic (AcF) and alkaline phosphatase (AlF), superoxide dismutase (SOD), catalase, glutathione reductase and malonic dialdehyde (MDA) content were determined in the bone tissue homogenates.
Results. Chronic alcohol consumption contributed to an increase in alveolar bone atrophy, increased activity of biochemical markers of bone resorption (elastase by 32.2 %, AcF – by 33.6 %), decreased osteogenesis (AlF activity by 32.4 %). Alcohol intoxication led to oxidative imbalance of bone tissue: a decrease in SOD activity by an average of 16.9 %, glutathione reductase activity by 36.2 %, increase in catalase activity by 35.9 % and an increase in MDA levels by 51.8 %.
Conclusion. Chronic alcohol consumption stimulates atrophy of the alveolar process of the rat jaw, induces oxidative imbalance in bone tissue, which can be a trigger pathogenetic factor in further development of resorption pro-inflammatory processes in bone tissue and inhibition of bone formation.
ABSORPTION OF CALCIUM IN SMALL INTESTINE OF RATS AFTER IMPACT OF VARIOUS XENOBIOTICS
Authors: Makarenko О. A. , Maikova H. V. , Kyrylenko N. A. , Hladkyi Т. V. , Eberle L. V. 
Published: October 2021

Relevance. Pathology of the thyroid and parathyroid glands, diseases of the digestive system, blood system, etc, as well as application of medications used for their treatment can result in the condition which is characterised by reduction of bone density – secondary osteoporosis.
The aim of the research was to determine absorption of calcium in the small intestine of rats under impact of various xenobiotics.
Materials and methods. The research was performed on white rats of herd breeding which, depending on the group obtained during 60 days: 1) cefoperazone (p/o, 180 mg/kg per day) and amoxiclav (p/o, 135 mg/kg per day); 2) mercazolil (p/o, 25 – 40 mg/kg per day); 3) L-thyroxine (p/o, 10 mg/kg per day); 4) hydrazine sulphate (50 mg/kg 2 times per week for 90 days).
Calcium absorption was studied in an isolated loop of the small intestine of the animals. The condition of the small intestine mucous membrane was estimated in accordance with inflammation markers (elastate and acid phosphatase activity, index of the degree of opportunistic microbiota (urease activity), index of non-specific antimicrobial protection of mucous membranes (lysozyme activity).
Long-term application of antibiotics contributed to reduction of calcium absorption in the small intestine of rats by 25.0 %, of mercazolil – by 29.7 %, of thyroxine – by 11.4 %, of hydrazine sulphate – by 34.5 %. The increase of elastase and acid phosphatase activity in the mucous membrane of the small intestine under the action of xenobiotics, as well as increase of urease activity and reduction of lysozyme activity testify to the change in the small intestine condition.
Сonclusions. So, the significant reduction of calcium absorption after long-term application of xenobiotics can be first of all connected with inhibition of antimicrobial protection of the small intestine mucous membrane under the action of antibiotics, mercazolil, thyroxine and hydrazine sulphate. More active multiplication of opportunistic bacteria, presence of dysbiosis, and, after application of antibiotics and hydrazine sulphate, development of inflammation can be the consequence of lysozyme activity reduction.
EXPERIMENTALSTUDY OF DYNAMIC EFFORTS DURING THE OPERATION OF THE MECHANISM OF MOVEMENT OF THE CARGO TROLLEYOF AN OVERHEAD CRANE
Authors: Fidrovska Nataliia , Slepuzhnikov Evgen , Ponomarenko Roman , Kozodoi Dmytro 
Published: October 2021

The article deals with the determination of the dynamic loads arising in the running wheels of a conventional (standard) and modernized design during the movement of the cargo carriage of an overhead crane. The redesigned wheel has an insert made from 7-7130 rubber compound. Also, a method for diagnosing running wheels of conventional and modernized design was determined.
The ZETLAB program was chosen as a program for signal registration and analysis. This program allows not only displaying the signal in real time with the possibility of scaling, but also allows you to digitize the signal with the possibility of further processing the results in various standards.
Finding out the occurrence of a defect in wheels and rails is mainly carried out by two methods, when shock pulses appear and according to an increased background of vibration. In practice, there is a process of "dry" rolling friction, and this means that the method of shock pulses for diagnosing the condition of wheels and a rail track can be used only in some cases in the form of extreme wear of the friction pairs of a wheel and a rail. That is, the method of spectral analysis of fluctuations in the power of random vibration can be successfully applied to diagnose the state of the rail track and crane wheel.
The diagnostic method based on the overall vibration level allows for an overall assessment of the technical condition. Such diagnostics makes it possible to identify defects only at the very last stage of development, when they lead or have already led to partial destruction of the rolling surface of the wheel and the surface of the rail, that is, to an increase in the overall level of vibration.
The performance evaluation criteria are fully focused on the corresponding standard vibration levels for the investigated friction pair. A friction pair is considered to be defective, the vibration of which exceeds the general standard. When determining an increased overall level of vibration, maintenance personnel must make a decision to replace parts or a unit to prolong its operation.
The results obtained indicate the advisability of using the wheels of the modernized design on the cargo carriage of an overhead crane.
ПОСТРОЕНИЕ ТРЕХМЕРНЫХ МОДЕЛЕЙ НЕФТЕНАСЫЩЕННОСТИ. ОСНОВНЫЕ ПРОБЛЕМЫ И ПОДХОДЫ К ИХ РЕШЕНИЮ
Authors: Белкина Валентина Александровна , Антипин Ярослав Олегович , Забоева Александра Александровна 
Published: October 2021

Актуальность развития методов построения трехмерных моделей начальной нефтенасыщенности обусловлена широким использованием их при решении важнейших задач нефтегазопромысловой геологии: подсчета запасов, проектирования и управления разработкой. Точность решения этих задач, в значительной степени обусловленная адекватностью и детальностью трехмерных моделей начальной нефтенасыщенности, позволяет заметно повысить эффективность извлечения углеводородов. Цель: проанализировать современное состояние алгоритмической и информационной базы трехмерного моделирования начальной нефтенасыщенности, выявить основные проблемы и наиболее перспективные направления их развития, позволяющие повысить их точность. Методы интерполяции и аппроксимации: детерминированные и стохастические, основанные на двух концепциях теории нефтегазонакопления: антиклинально-гравитационной и относительно недавно появившейся капиллярно-гравитационной. Для различных геологических ситуаций эти методы модифицируются способами использования широкого набора косвенной и априорной информации. Результаты. Выявлены основные возможности повышения точности трехмерных моделей начальной нефтенасыщенности. Во-первых, это создание методов, учитывающих наличие водонефтяных переходных зон, характерных для терригенных полимиктовых пород-коллекторов. Во-вторых, создание дискретно-непрерывных моделей, например, с классификацией по пористости. В этом подходе область моделирования разбивается на отдельные части, в каждой из которых используются свои тренды (одномерные, двумерные и трехмерные). Построение трендов основано на всем комплексе имеющейся эмпирической информации: данных РИГИС, гидродинамических исследований и результатах капиллярометрических исследований. Проклассифицированы способы проверки качества исходных данных и адекватности построенных моделей. Приведены конкретные алгоритмы создания моделей по двум наиболее перспективным направлениям развития алгоритмической базы трехмерного моделирования начальной нефтенасыщенности.
Participation and Psychological Capital in Adults With Parkinson's Disease: Mediation Analysis Based on the International Classification of Functioning, Disability, and Health
Authors: McDaniels Bradley , Bishop Malachy 
Published: October 2021

ObjectiveThe purpose of this study was to explore how the functional impact of Parkinson's disease affects participation and to evaluate whether positive psychological capital (PsyCap) mediates the relationship within the context of the World Health Organization International Classification of Functioning, Disability, and Health Model.MethodSurvey responses were analyzed from 144 adults with Parkinson's disease using a quantitative, correlational research design employing multiple regression and hierarchical regression analysis to examine hypothesized relationships.ResultsThe results of the correlation analysis indicated that there was a statistically significant, moderate-to-strong positive correlation between functioning and PsyCap and participation. Hierarchical regression analysis revealed that functioning accounted for 65% of the variance in participation. Although PsyCap was associated with participation, no mediating effect was observed.ConclusionsThe results are consistent with traditional clinical judgment that physical functioning is positively correlated with participation. This study represents the first evaluation of the role of PsyCap in people with Parkinson's disease, and the results of the correlational analysis suggest that continued investigation of these relationships is warranted.BackgroundParkinson's disease results in a variety of motor and non-motor features that frequently result in reduced participation in valued life activities.
Vibroextrusion flow of concrete mixtures in a right four-corner pyramidal channel
Authors: Andreiev Igor , Pinchuk Andrey , Kramar Oleksandra 
Published: October 2021

The purpose of the research was to obtain calculation formulas for describing the flow of concrete mixtures and determining their viscosity directly in the process of vibroextrusion in regular quadrangular pyramidal channels.
In solving the flow problems, it was taken into account that concrete mixtures are non-Newtonian systems in the conditions of a vibration field, and hydrodynamic theories were used to calculate the processes and rheological characteristics.
Since the calculation formulas for describing the flow of fluids in a regular quadrangular pyramidal channel are absent and the channel has a square cross section, an analytical dependence was used to characterize the process, which describes the flow of a Newtonian fluid in a rectangular channel of constant cross section. The authors proposed for use simplified formulas for determining the maximum flow rate and flow rate of a Newtonian fluid in a channel of rectangular cross-section.
The degree of decrease in the flow velocity and the flow rates of a Newtonian fluid in a channel of rectangular cross-section in comparison with the flow between flat parallel plates are analyzed.
To describe the flow of concrete mixtures in regular quadrangular pyramidal channels, the proposed coefficients for reducing the speed and flow rate, as well as the existing formulas for the flow between flat symmetric stationary walls, which converge, were used.
The possibility of using the obtained formula for the flow rate in a regular quadrangular pyramidal channel for calculating the viscosity of a concrete mixture during vibration extrusion is shown. To simplify the experimental procedure, a new formula for calculating the viscosity based on the expiration time for a certain amount of concrete mixture has been proposed.
The formulas obtained are convenient for further mathematical processing and have no restrictions in their application. The proposed method for determining the viscosity expands the possibilities of studying the rheological properties of concrete mixtures in the vibroextrusion of fiber-reinforced concrete mixtures.
O Dark Side da Digitalização na Era do Capitalismo de Vigilância: Um estudo dos Termos de Consentimento da Uber à Luz da Legislação Brasileira
Authors: Vianna Fernando Ressetti Pinheiro Marques , Da Rosa Maia Ressetti Vianna Juliana , Kanashiro Meneghetti Francis 
Published: October 2021

Objetivo: Analisamos os tipos de más-condutas que compõem os Termos de Consentimento de uma organização digitalizada, na era do capitalismo de vigilância, e a conduta do Estado em relação a tais práticas.
Enquadramento teórico: O artigo é desenvolvido a partir de uma perspectiva crítica amparada pelas teorias do drak side das organizações e do capitalismo de vigilância. Justifica-se tal opção pela relação de causa e efeito entre o chamado capitalismo de vigilância, e as práticas caracterizadas como má-conduta pela teoria do dark-side das organizações.
Metodologia: Adotou-se o método de análise documental, por meio do qual analisamos o conteúdo dos Termos de Consentimento da Uber e das Leis nº 12.965 de 2014 (“Marco Civil da Internet”), e nº 13.709 de 2018 (Lei Geral de Proteção de Dados).
Resultados: Verificou-se que os Termos de Consentimento da Uber conflitam com as Leis em mais de setenta pontos e obscurecem as práticas de expropriação de dados, caracterizando uma má conduta da organização. A legislação criada para proteger o usuário e seus dados tem sua vigência sistematicamente prorrogada, protegendo as organizações do capitalismo de vigilância e deixando os usuários vulneráveis.
Originalidade: O artigo amplia os estudos sobre a digitalização, que costumam analisá-la como avanço tecnológico ou forma de precarização do trabalho, em perspectivas funcionalistas ou críticas, respectivamente. Assim, analisamos a digitalização como forma de organizar a expropriação de dados dos usuários, para garantir os resultados financeiros e poder para as organizações.
Contribuições teóricas e práticas: A principal contribuição teórica desse trabalho repousa sobre o avanço da teoria do dark side das organizações e sua relação com o conceito de capitalismo de vigilância, e o papel do Estado no mundo digitalizado. Sobre as contribuições práticas, acreditamos que em uma sociedade digitalizada, a atenção à operacionalização das organizações plataformizadas é emergencial, assim como a cobrança da atuação do Estado como ator principal na regulação das relações entre plataformas e usuários.
Inovação e colaboração governamental para recuperar veículos roubados e furtados
Authors: Viana Guimarães Arthur , Cabral Sandro , Fernandes Ribeiro Priscila , Marchesini da Costa Marcelo 
Published: October 2021

Objetivo da pesquisa: O objetivo deste trabalho é discutir em que medida a intensidade de colaboração entre diferentes esferas governamentais molda o desempenho organizacional obtido a partir de inovações tecnológicas no setor público, tendo como base a implementação de um sistema de recuperação de veículos roubados e furtados, em que a Prefeitura de São Paulo e a Polícia Militar do Estado de São Paulo agiram conjuntamente.
Enquadramento teórico: Utiliza-se, como suporte para a análise, a literatura sobre governança colaborativa e inovações em governos, com destaque para a sua aplicação na área de segurança pública.
Metodologia: Por meio de regressões logísticas e análise de clusters espaciais, analisamos dados referentes a 319.487 veículos subtraídos no município de São Paulo entre 2015 e 2017.
Resultados: Enquanto identificamos um aumento estatisticamente relevante na probabilidade de se recuperar um veículo em decorrência dos esforços colaborativos empregados, encontramos também resultados heterogêneos nos diferentes distritos do município de São Paulo.
Originalidade: Este trabalho supre uma deficiência da literatura na medida em que, apesar do crescente uso de inovações como forma de aprimorar serviços públicos, pouco se sabe sobre a intensidade de colaboração necessária para gerar os resultados desejados diante da adoção de novas tecnologias.
Contribuições teóricas e práticas: Os resultados sugerem que a efetividade de inovações está associada à intensidade de colaboração entre os diferentes órgãos públicos. Isso indica caminhos para que a gestão pública potencialize os benefícios de inovações em suas atividades.
Droplet-based single-cell RNA sequencing of paraformaldehyde-fixed cells
Authors: Phan Hoang Van , Gent Michiel van , Drayman Nir , Basu Anindita , Gack Michaela U. , Tay Savas 
Published: October 2021

Abstract
Paraformaldehyde (PFA) fixation is a common fixation technique. However, current high-throughput single-cell RNA sequencing (scRNA-seq) methods are not compatible with PFA-fixed cells. Here we introduce FD-seq (Fixed Droplet RNA Sequencing), a method for droplet-based scRNA-seq of PFA-fixed, stained and sorted cells. FD-seq offers greater flexibility for researchers, and can readily be incorporated with existing Drop-seq experimental setup.