bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palliative Care for Extracorporeal Life Support: Insights From the National Inpatient Sample
Authors: Williamson Catherine , Verma Arjun , Hadaya Joseph , Tran Zachary , Sanaiha Yas , Benharash Peyman 
Published: June 2021

Background Providing temporary cardiopulmonary support, extracorporeal membrane oxygenation (ECMO) carries a high risk of mortality. Palliative care (PC) may facilitate a patient-centered approach to end-of-life care in order to aid symptom management and provide psychosocial support to families. The present study aimed to identify factors associated with PC consultation and its impact on resource utilization in ECMO. Study Design All adults placed on ECMO at a PC capable center were identified in the 2006-2017 National Inpatient Sample. Indications for ECMO were identified using diagnosis codes and classified into postcardiotomy syndrome, respiratory failure, cardiogenic shock, mixed cardiopulmonary failure, and transplant related. Results Of 41 122 patients undergoing ECMO, 20 514 (49.9%) died in the same hospitalization. Of those, 3951 (19.3%) received a PC consult. Use of PC consults increased significantly from 5.5% in 2006 to 22.8% in 2017 (nptrend<.001). After multivariable risk adjustment, PC consults did not affect costs (β: –$7341, 95% CI: −22 572 to +7888) or duration of hospitalizations (β: −.37 days, 95% CI: −2.76 to +2.02). Conclusion Utilization of PC does not appear to negatively influence resource utilization among non-survivors of ECMO. Increased adaptation of PC in ECMO may improve end-of-life care, a factor that deserves future study.
Psychomythology of Psychopathology: Myths and Mythbusting in Teaching Abnormal Psychology
Authors: Curtis Drew A. , Kelley Leslie J. 
Published: June 2021

Background: A great amount of information is presented to psychology students through various mediums, often leading to misinformation and believing inaccurate psychological myths. Objective: We conducted two studies to examine psychomythology of psychopathology and whether mythbusting may be an effective pedagogical tool. Method: In Study 1, a total of 251 participants were recruited and asked about psychology myths they believed by using the Myths of Abnormal Psychology Questionnaire (MAP). In Study 2, a total of 46 students across two sections of abnormal psychology courses were asked about psychological myths they believed at the onset of class and at the end of class using the MAP. These students also were provided with an educational mythbusting intervention throughout the class. Results: Participants endorsed several myths of psychopathology and indicated that the greatest sources of their understanding came from instructors, the internet, movies, and mythbusting led to a decrease in myth endorsement. Conclusion: Students enter abnormal psychology courses believing several inaccurate myths and mythbusting appears to be a viable tool to address these misconceptions. Teaching Implications: Mythbusting can be implemented within abnormal psychology courses as an an engaging and effective teaching tool, as well as a means to model scientific thinking.
Post-Run T2 Mapping Changes in Knees of Adolescent Basketball Players
Authors: Chechik Yigal , Beit Ner Eran , Lysyy Oleg , Tal Sigal , Stern Neta , Agar Gabriel , Beer Yiftach , Ben-Eliezer Noam , Lindner Dror 
Published: June 2021

Objective: While articular cartilage defects are common incidental findings among adult athletes, the effect of running on the cartilage of adolescent athletes have rarely been assessed. This study aims to assess the variations in the articular cartilage of the knees in healthy adolescent basketball players using quantitative T2 MRI (magnetic resonance imaging). Design: Fifteen adolescent basketball players were recruited (13.8 ± 0.5 years old). Girls were excluded to avoid potential gender-related confounding effects. Players underwent a pre-run MRI scan of both knees. All participants performed a 30-minute run on a treadmill. Within 15 minutes after completion of their run, players underwent a second, post-run MRI scan. Quantitative T2 maps were generated using the echo modulation curve (EMC) algorithm. Pre-run scans and post-run scans were compared using paired t test. Results: Participants finished their 30-minute run with a mean running distance of 5.77 ± 0.42 km. Pre-run scans analysis found statistically significant ( P < 0.05) changes in 3 regions of the knee lateral compartment representing the cartilaginous tissue. No differences were found in the knee medial compartment. Post-run analysis showed lower T2 values in the medial compartment compared to the pre-run scans in several weight-bearing regions: femoral condyle central (pre/post mean values of 33.9/32.2 ms, P = 0.020); femoral condyle posterior (38.1/36.8 ms, P = 0.038); and tibial plateau posterior (34.1/31.0 ms, P < 0.001). The lateral regions did not show any significant changes. Conclusions: Running leads to microstructural changes in the articular cartilage in several weight-bearing areas of the medial compartment, both in the femoral and the tibial cartilage.
Increased Construct Stiffness With Meniscal Repair Sutures and Devices Increases the Risk of Cheese-Wiring During Biomechanical Load-to-Failure Testing
Authors: Müller Sebastian , Schwenk Tanja , de Wild Michael , Dimitriou Dimitris , Rosso Claudio 
Published: June 2021

Background: Cheese-wiring, the suture that cuts through the meniscus, is a well-known issue in meniscal repair. So far, contributing factors are neither fully understood nor sufficiently studied. Hypothesis/Purpose: To investigate whether the construct stiffness of repair sutures and devices correlates with suture cut-through (cheese-wiring) during load-to-failure testing. Study Design: Controlled laboratory study. Methods: In 131 porcine menisci, longitudinal bucket-handle tears were repaired using either inside-out sutures (n = 66; No. 0 Ultrabraid, 2-0 Orthocord, 2-0 FiberWire, and 2-0 Ethibond) or all-inside devices (n = 65; FastFix360, Omnispan, and Meniscal Cinch). After cyclic loading, load-to-failure testing was performed. The mode of failure and construct stiffness were recorded. A receiver operating characteristic curve analysis was performed to define the optimal stiffness threshold for predicting meniscal repair failure by cheese-wiring. The 2-tailed t test and analysis of variance were used to test significance. Results: Loss of suture fixation was the most common mode of failure in all specimens (58%), except for the Omnispan, which failed most commonly because of anchor pull-through. The Omnispan demonstrated the highest construct stiffness (30.8 ± 3.5 N/mm), whereas the Meniscal Cinch (18.0 ± 8.8 N/mm) and Ethibond (19.4 ± 7.8 N/mm) demonstrated the lowest construct stiffness. The Omnispan showed significantly higher stiffness compared with the Meniscal Cinch ( P < .001) and Ethibond ( P = .02), whereas the stiffness of the Meniscal Cinch was significantly lower compared with that of the FiberWire ( P = .01), Ultrabraid ( P = .04), and FastFix360 ( P = .03). While meniscal repair with a high construct stiffness more often failed by cheese-wiring, meniscal repair with a lower stiffness failed by loss of suture fixation, knot slippage, or anchor pull-through. Meniscal repair with a stiffness >26.5 N/mm had a 3.6 times higher risk of failure due to cheese-wiring during load-to-failure testing (95% CI, 1.4-8.2; P < .0001). Conclusion: Meniscal repair using inside-out sutures and all-inside devices with a higher construct stiffness (>26.5 N/mm) was more likely to fail through suture cut-through (cheese-wiring) than that with a lower stiffness (≤26.5 N/mm). Clinical Relevance: This is the first study investigating the impact of construct stiffness on meniscal repair failure by suture cut-through (cheese-wiring).
Multi-labelled proteins recognition for high-throughput microscopy images using deep convolutional neural networks
Authors: Zhang Enze , Zhang Boheng , Hu Shaohan , Zhang Fa , Liu Zhiyong , Wan Xiaohua 
Published: June 2021

AbstractBackgroundProteins are of extremely vital importance in the human body, and no movement or activity can be performed without proteins. Currently, microscopy imaging technologies developed rapidly are employed to observe proteins in various cells and tissues. In addition, due to the complex and crowded cellular environments as well as various types and sizes of proteins, a considerable number of protein images are generated every day and cannot be classified manually. Therefore, an automatic and accurate method should be designed to properly solve and analyse protein images with mixed patterns.ResultsIn this paper, we first propose a novel customized architecture with adaptive concatenate pooling and “buffering” layers in the classifier part, which could make the networks more adaptive to training and testing datasets, and develop a novel hard sampler at the end of our network to effectively mine the samples from small classes. Furthermore, a new loss is presented to handle the label imbalance based on the effectiveness of samples. In addition, in our method, several novel and effective optimization strategies are adopted to solve the difficult training-time optimization problem and further increase the accuracy by post-processing.ConclusionOur methods outperformed the SOTA method of multi-labelled protein classification on the HPA dataset, GapNet-PL, by above 2% in the F1 score. Therefore, experimental results based on the test set split from the Human Protein Atlas dataset show that our methods have good performance in automatically classifying multi-class and multi-labelled high-throughput microscopy protein images.
Transcriptomic responses to drought stress among natural populations provide insights into local adaptation of weeping forsythia
Authors: Li Yong , Shi Long-Chen , Pei Nan-Cai , Cushman Samuel A. , Si Yu-Tao 
Published: June 2021

Abstract
Background
Understanding the genetic mechanisms of local adaptation is an important emerging topic in molecular ecology and evolutionary biology.

Results
Here, we identify the physiological changes and differential expression of genes among different weeping forsythia populations under drought stress in common garden experiments. Physiological results showed that HBWZ might have higher drought tolerance among four populations. RNA-seq results showed that significant differential expression in the genes responding to the synthesis of flavonoids, aromatic substances, aromatic amino acids, oxidation–reduction process, and transmembrane transport occured among four populations. By further reanalysis of results of previous studies, sequence differentiation was found in the genes related to the synthesis of aromatic substances among different weeping forsythia populations.

Conclusions
Overall, our study supports the hypothesis that the dual differentiation in gene efficiency and expression increases among populations in response to heterogeneous environments and is an important evolutionary process of local adaptation. Here, we proposed a new working model of local adaptation of weeping forsythia populations under different intensities of drought stress, which provides new insights for understanding the genetic mechanisms of local adaptation for non-model species.
Evaluation of acute flaccid paralysis surveillance indicators in Sokoto state, Nigeria, 2012–2019: a secondary data analysis
Authors: Raji Ismail Abdullateef , Abubakar Auwal Usman , Ahmad Abdulrahman , Gidado Saheed , Olorukooba Abdulhakeem Abayomi , Lawal Bola Biliaminu , Umeokonkwo Chukwuma David , Balogun Muhammad 
Published: June 2021

Abstract
Background
Nigeria, the last endemic country in the WHO African Region, was certified free of Wild Polio Virus (WPV) in 2020. However, due to low immunity in some communities in Sokoto, outbreaks of the circulating Vaccine Derived Polio Virus (cVDPV) occur. The aim of this study is to evaluate the Acute Flaccid Paralysis (AFP) surveillance indicators in Sokoto state, Nigeria.

Methods
This retrospective study was an analysis of routinely collected AFP surveillance data between 2012 and 2019 by the Sokoto state surveillance network. We assessed the Sokoto state AFP surveillance system using the AFP surveillance performance indicators. We performed all analyses using Microsoft Excel 2019.

Results
Cumulatively, 3001 Acute Flaccid Paralysis (AFP) cases were reported over the evaluation period, out of which 1692 (56.4%) were males, and 2478 (82.4%) were below five years. More than half, 1773 (59.1%), had a fever at the beginning of the disease, and 1911 (63.7%) had asymmetric paralysis. The non-polio AFP rate (9.1 to 23.5% per 100,000 children < 15 years old) and stool adequacy rate (92.5 to 100%) indicate high sensitivity. The proportion of cases that had stool samples collected early, timely transported to the laboratory and arrived at the laboratory in optimal condition were all above the World Health Organization (WHO) minimum standard of 80%. There was inadequate profile documentation of some suspected cases.

Conclusions
Sokoto State has exceeded the WHO minimum standards in most of the AFP surveillance indicators. The performance of the system is sufficient enough to detect any reintroduction of WPV into the state. However, there is a need for improvement in data quality.
Record linkage under suboptimal conditions for data-intensive evaluation of primary care in Rio de Janeiro, Brazil
Authors: Coeli Claudia Medina , Saraceni Valeria , Medeiros Paulo Mota , da Silva Santos Helena Pereira , Guillen Luis Carlos Torres , Alves Luís Guilherme Santos Buteri , Hone Thomas , Millett Christopher , Trajman Anete , Durovni Betina 
Published: June 2021

Abstract
Background
Linking Brazilian databases demands the development of algorithms and processes to deal with various challenges including the large size of the databases, the low number and poor quality of personal identifiers available to be compared (national security number not mandatory), and some characteristics of Brazilian names that make the linkage process prone to errors. This study aims to describe and evaluate the quality of the processes used to create an individual-linked database for data-intensive research on the impacts on health indicators of the expansion of primary care in Rio de Janeiro City, Brazil.

Methods
We created an individual-level dataset linking social benefits recipients, primary health care, hospital admission and mortality data. The databases were pre-processed, and we adopted a multiple approach strategy combining deterministic and probabilistic record linkage techniques, and an extensive clerical review of the potential matches. Relying on manual review as the gold standard, we estimated the false match (false-positive) proportion of each approach (deterministic, probabilistic, clerical review) and the missed match proportion (false-negative) of the clerical review approach. To assess the sensitivity (recall) to identifying social benefits recipients’ deaths, we used their vital status registered on the primary care database as the gold standard.

Results
In all linkage processes, the deterministic approach identified most of the matches. However, the proportion of matches identified in each approach varied. The false match proportion was around 1% or less in almost all approaches. The missed match proportion in the clerical review approach of all linkage processes were under 3%. We estimated a recall of 93.6% (95% CI 92.8–94.3) for the linkage between social benefits recipients and mortality data.

Conclusion
The adoption of a linkage strategy combining pre-processing routines, deterministic, and probabilistic strategies, as well as an extensive clerical review approach minimized linkage errors in the context of suboptimal data quality.
Developing automated methods for disease subtyping in UK Biobank: an exemplar study on stroke
Authors: Rannikmäe Kristiina , Wu Honghan , Tominey Steven , Whiteley William , Allen Naomi , Sudlow Cathie ,   the UK Biobank
Published: June 2021

Abstract
Background
Better phenotyping of routinely collected coded data would be useful for research and health improvement. For example, the precision of coded data for hemorrhagic stroke (intracerebral hemorrhage [ICH] and subarachnoid hemorrhage [SAH]) may be as poor as < 50%. This work aimed to investigate the feasibility and added value of automated methods applied to clinical radiology reports to improve stroke subtyping.

Methods
From a sub-population of 17,249 Scottish UK Biobank participants, we ascertained those with an incident stroke code in hospital, death record or primary care administrative data by September 2015, and ≥ 1 clinical brain scan report. We used a combination of natural language processing and clinical knowledge inference on brain scan reports to assign a stroke subtype (ischemic vs ICH vs SAH) for each participant and assessed performance by precision and recall at entity and patient levels.

Results
Of 225 participants with an incident stroke code, 207 had a relevant brain scan report and were included in this study. Entity level precision and recall ranged from 78 to 100%. Automated methods showed precision and recall at patient level that were very good for ICH (both 89%), good for SAH (both 82%), but, as expected, lower for ischemic stroke (73%, and 64%, respectively), suggesting coded data remains the preferred method for identifying the latter stroke subtype.

Conclusions
Our automated method applied to radiology reports provides a feasible, scalable and accurate solution to improve disease subtyping when used in conjunction with administrative coded health data. Future research should validate these findings in a different population setting.
Evidence-based narratives in European research programming
Authors: Schepelmann Philipp , Fischer Susanne , Drews Martin , Bastein Ton , Kropp Jürgen , Krummenauer Linda , Augenstein Karoline 
Published: June 2021

AbstractThe article introduces and exemplifies the approach of evidence-based narratives (EBN). The methodology is a product of co-design between policy-making and science, generating robust intelligence for evidence-based policy-making in the Directorate General for Research and Innovation of the European Commission (DG RTD) under the condition of high uncertainty and fragmented evidence. The EBN transdisciplinary approach tackles practical problems of future-oriented policy-making, in this case in the area of programming for research and innovation addressing the Grand Societal Challenge related to climate change and natural resources. Between 2013 and 2018, the EU-funded RECREATE project developed 20 EBNs in a co-development process between scientists and policy-makers. All EBNs are supported with evidence about the underlying innovation system applying the technological innovation systems (TIS) framework. Each TIS analysis features the innovation, its current state of market diffusion and a description of the innovation investment case. Indicators include potential future market sizes, effects on employment and environmental and social benefits. Based on the innovation and TIS function analyses, the EBNs offer policy recommendations. The article ends with a critical discussion of the EBN approach.
Investigating the associations of early numeracy activities and skills with mathematics dispositions, engagement, and achievement among fourth graders in the United Arab Emirates
Authors: Balala Maha Mohamed Abdulla , Areepattamannil Shaljan , Cairns Dean 
Published: June 2021

AbstractThe present study aimed to examine the relations of early numeracy activities and skills to mathematics dispositions, engagement, and achievement among 26,859 fourth graders in the United Arab Emirates who took part in the sixth cycle of the Trends in International Mathematics and Science Study (TIMSS) in 2015. The study also explored the mediating effects of mathematics dispositions and engagement on the relations between early numeracy activities and skills and mathematics achievement among these fourth graders. Results of path analyses, after controlling for participants’ demographic and socioeconomic characteristics, indicated that early numeracy activities and skills were significantly and positively related to mathematics dispositions, engagement, and achievement. Further, results of mediational analyses suggested that confidence in mathematics had a significant mediating effect on the relations between early numeracy activities and skills and mathematics achievement. The findings of the study highlight the crucial role that early numeracy activities and skills play in enhancing fourth graders’ mathematics dispositions, engagement, and achievement in the United Arab Emirates.
Imaging ground surface deformations in post-disaster settings via small UAVs
Authors: Ybañez Richard L. , Ybañez Audrei Anne B. , Lagmay Alfredo Mahar Francisco A. , Aurelio Mario A. 
Published: June 2021

AbstractSmall unmanned aerial vehicles have been seeing increased deployment in field surveys in recent years. Their portability, maneuverability, and high-resolution imaging are useful in mapping surface features that satellite- and plane-mounted imaging systems could not access. In this study, we develop and apply a workplan for implementing UAV surveys in post-disaster settings to optimize the flights for the needs of the scientific team and first responders. Three disasters caused by geophysical hazards and their associated surface deformation impacts were studied implementing this workplan and was optimized based on the target features and environmental conditions. An earthquake that caused lateral spreading and damaged houses and roads near riverine areas were observed in drone images to have lengths of up to 40 m and vertical displacements of 60 cm. Drone surveys captured 2D aerial raster images and 3D point clouds leading to the preservation of these features in soft-sedimentary ground which were found to be tilled over after only 3 months. The point cloud provided a stored 3D environment where further analysis of the mechanisms leading to these fissures is possible. In another earthquake-devastated locale, areas hypothesized to contain the suspected source fault zone necessitated low-altitude UAV imaging below the treeline capturing Riedel shears with centimetric accuracy that supported the existence of extensional surface deformation due to fault movement. In the aftermath of a phreatomagmatic eruption and the formation of sub-metric fissures in nearby towns, high-altitude flights allowed for the identification of the location and dominant NE–SW trend of these fissures suggesting horst-and-graben structures. The workplan implemented and refined during these deployments will prove useful in surveying other post-disaster settings around the world, optimizing data collection while minimizing risk to the drone and the drone operators.