bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis
Authors: Lan Yujia , Zhao Erjie , Zhang Xinxin , Zhu Xiaojing , Wan Linyun , A Suru , Ping Yanyan , Wang Yihan 
Published: August 2021

Background
Glioblastoma multiforme (GBM) is a highly, malignant tumor of the primary central nervous system. Patients diagnosed with this type of tumor have a poor prognosis. Lymphocyte activation plays important roles in the development of cancers and its therapeutic treatments.

Objective
We sought to identify an efficient lymphocyte activation-associated gene signature that could predict the progression and prognosis of GBM.

Methods
We used univariate Cox proportional hazards regression and stepwise regression algorithm to develop a lymphocyte activation-associated gene signature in the training dataset (TCGA, n = 525). Then, the signature was validated in two datasets, including GSE16011 (n = 150) and GSE13041 (n = 191) using the Kaplan Meier method. Univariate and multivariate Cox proportional hazards regression models were used to adjust for clinicopathological factors.

Results
We identified a lymphocyte activation-associated gene signature (TCF3, IGFBP2, TYRO3 and NOD2) in the training dataset and classified the patients into high-risk and low-risk groups with significant differences in overall survival (median survival 15.33 months vs 12.57 months, HR = 1.55, 95% CI [1.28–1.87], log-rank test P < 0.001). This signature showed similar prognostic values in the other two datasets. Further, univariate and multivariate Cox proportional hazards regression models analysis indicated that the signature was an independent prognostic factor for GBM patients. Moreover, we determined that there were differences in lymphocyte activity between the high- and low-risk groups of GBM patients among all datasets. Furthermore, the lymphocyte activation-associated gene signature could significantly predict the survival of patients with certain features, including IDH-wildtype patients and patients undergoing radiotherapy. In addition, the signature may also improve the prognostic power of age.

Conclusions
In summary, our results suggested that the lymphocyte activation-associated gene signature is a promising factor for the survival of patients, which is helpful for the prognosis of GBM patients.
Segmented Swing‐Structured Fur‐Based Triboelectric Nanogenerator for Harvesting Blue Energy toward Marine Environmental Applications
Authors: Pang Hao , Feng Yawei , An Jie , Chen Pengfei , Han Jiajia , Jiang Tao , Wang Zhong Lin 
Published: August 2021

AbstractReducing carbon emissions to realize carbon neutrality is crucial to the environmental protection, and developing clean and renewable energy sources is an effective means to achieve this goal. Triboelectric nanogenerators (TENGs) provide a promising energy technology for converting the abundant renewable ocean wave energy on the earth surface. In this work, a segmented swing‐structured fur‐based TENG (SSF‐TENG) is designed and fabricated to harvest low frequency water wave energy. The introduction of soft and dense rabbit furs reduces the frictional resistance and material wear, and the design and optimization of segmented structures further enhance the output performance of TENG. The use of ultra‐lubricated bearings makes the SSF‐TENG achieve an extended period of energy harvesting of more than 5 min after one triggering, with a total energy conversion efficiency of up to 23.6%. Under the real water wave triggering, the SSF‐TENG can deliver a maximum peak power of 6.2 mW and an average power of 0.74 mW. Furthermore, through effective water wave energy harvesting by the SSF‐TENG or array, self‐powered marine environmental applications are successfully demonstrated, which establishes a solid foundation for large‐scale blue energy harvesting and realization of smart oceans.
Silicon Anodes with Improved Calendar Life Enabled By Multivalent Additives
Authors: Zhang Yunya , Li Xiang , Sivonxay Eric , Wen Jianguo , Persson Kristin A. , Vaughey John T. , Key Baris , Dogan Fulya 
Published: August 2021

AbstractSilicon is widely recognized as the most promising upgrade for graphite anodes due to its much higher capacity, natural abundance, and ability to be directly applied in the slurry‐based, roll‐to‐roll production lines. However, in addition to the fast capacity decay, silicon anodes also suffer from inferior calendar life in practical applications due to the unstable solid‐electrode interface (SEI). Until now, strategies to effectively improve the calendar life by tailored SEIs remain largely unclear, especially in high‐Si content, zero‐graphite anodes. Here, silicon anodes with superior calendar life are developed by adding small concentrations of multivalent salts into the baseline electrolyte. The Ca additive reacts with the F ions in the electrolyte, forming a layer of nanocrystalline CaF2 that is closely coated around the silicon particles. The CaF2‐enabled new SEI is strong and dense, which effectively protects the silicon core from side reactions, leading to lower capacity decay after calendar aging at high voltage. More importantly, the Ca additive is effective universally for all available commercial silicon or SiO sources. This study provides a feasible and low‐cost solution for developing silicon anodes with long calendar life, paving the way towards commercially viable silicon anodes.
Filler‐size‐dependent dynamic mechanical properties of polyethylene glycol/zircon composites
Authors: Fauziyah Nur Aini , Nurmalasari Muthia Diah , Hilmi Allif Rosyidy , Triwikantoro Triwikantoro , Baqiya Malik Anjelh , Zainuri Mochamad , Pratapa Suminar 
Published: August 2021

AbstractThe thermomechanical properties of polyethylene glycol (PEG) composites filled with various zircon sizes were studied. The zircon powders were derived from natural (well‐known as puya) sand collected from Kereng Pangi, Central Kalimantan, Indonesia. The effects of the zircon size and content were examined to understand the thermomechanical properties of the composites using dynamic mechanical analysis in shear mode. Pure zircon powders with micron to nanometer sizes were prepared. The microzircon powders were prepared by heating zircon at 500, 1000, and 1200°C. Moreover, the nanozircon powders were prepared by a wet milling method with milling times of 5, 10, and 15 hours. Furthermore, the composites were prepared by a wet mixing method. According to elemental analysis of scanning electron microscopy/energy dispersive X‐Ray spectroscopy (SEM/EDX) data, it was found that the various zircon sizes caused different distribution effects, that is, in general, the smaller the size was, the better the distribution. Filler size variation also affected the thermomechanical properties of the composites. The addition of microzircon heated at 1200°C had the lowest storage moduli (G'), that is, 154.90 MPa and 155.55 MPa for 5 wt.% and 10 wt.%, respectively. Moreover, the maximum value of G' was obtained for the composite with the addition of nanozircon milled for 10 h (Z10h), that is, 679.27 MPa and 706.37 MPa for 5 and 10 wt.%, respectively. The addition of nanozircon slightly reduced room‐temperature G', presumably due to the agglomerated filler, as confirmed by the SEM/EDX data. Moreover, a decrease in zircon size caused an increase in the melting temperature (Tm) of the matrix. In contrast, 15 h of milling had a minor effect on Tm and G', whereas the loss modulus (G") decreased with the addition of nanozircon. The effects of filler size on the thermomechanical properties of PEG/zircon composites are discussed in detail.
Human body donation: How informed are the donors?
Authors: Zealley Jeffrey A. , Howard Dana , Thiele Courtney , Balta Joy Y. 
Published: August 2021

AbstractDeceased human bodies are donated for education and research. Informed consent has become the standard for research on the living. A question could be asked on how informed are the donors and their families about the process before this generous gift is given. The aim of this study is to evaluate and compare the published donation forms used by body donation programs in the United States and assess them according to the guidelines published by the American Association of Clinical Anatomists. The findings of this study shows that the level of information given to donors and families, before consenting to whole body donation, varies greatly throughout the United States. Many of the forms fail to include the recommendations made by professional societies. Additional information needs to be added to whole body donation forms to better inform donors and families about the donation process, what happens to the body, and the final disposition of the bodies once studies are completed. Overall, it was concluded that in some cases consent is being obtained but much more needs to be done before institutions can claim to obtain informed consent.
Late metastatic presentation is associated with improved survival and delayed wide‐spread progression after ablative stereotactic body radiotherapy for oligometastasis
Authors: Chen Xuguang , Chen Hanbo , Poon Ian , Erler Darby , Badellino Serena , Biswas Tithi , Dagan Roi , Foote Matthew , Louie Alexander V. , Ricardi Umberto , Sahgal Arjun , Redmond Kristin J. 
Published: August 2021

AbstractBackgroundStereotactic body radiotherapy (SBRT) is increasingly used to treat oligometastatic disease (OMD), but the effect of metastasis timing on patient outcomes remains uncertain.MethodsAn international database of patients with OMD treated with SBRT was assembled with rigorous quality assurance. Early versus late metastases were defined as those diagnosed ≤24 versus >24 months from the primary tumor. Overall survival (OS), progression‐free survival (PFS), and incidences of wide‐spread progression (WSP) were estimated using multivariable Cox proportional hazard models stratified by primary tumor types.ResultsThe database consists of 1033 patients with median follow‐up of 24.1 months (0.3–104.7). Late metastatic presentation (N = 427) was associated with improved OS compared to early metastasis (median survival 53.6 vs. 33.0 months, hazard ratio [HR] 0.59, 95% confidence interval [CI]: 0.47–0.72, p < 0.0001). Patients with non‐small cell lung cancer (NSCLC, N = 255, HR 0.49, 95% CI: 0.33–0.74, p = 0.0005) and colorectal cancer (N = 235, HR 0.50, 95% CI: 0.30–0.84, p = 0.008) had better OS if presenting with late metastasis. Late metastasis correlated with longer PFS (median 17.1 vs. 9.0 months, HR 0.71, 95% CI: 0.61–0.83, p < 0.0001) and lower 2‐year incidence of WSP (26.1% vs. 43.6%, HR 0.60, 95% CI: 0.49–0.74, p < 0.0001). Fewer WSP were observed in patients with NSCLC (HR 0.52, 95% CI: 0.33–0.83, p = 0.006) and kidney cancer (N = 63, HR 0.37, 95% CI: 0.14–0.97, p = 0.044) with late metastases. Across cancer types, greater SBRT target size was a significant predictor for worse OS.ConclusionLate metastatic presentation is associated with improved survival and delayed progression in patients with OMD treated with SBRT.
Psoriatic transversal nail grooves on biologics
Authors: Yamanaka Keiichi , Kondo Makoto 
Published: August 2021

AbstractWe noticed transverse grooves on the nails of a psoriasis vulgaris patient being treated with ixekizumab. The indentation might have appeared during the period when the effective concentration of ixekizumab was low and psoriasis activity in the nail matrix had increased shortly before the monthly dose.
Indolent renal involvement with BRAFV600E mutation: Erdheim‐Chester, a rare disease with a wide spectrum of clinical manifestations
Authors: Vanhomwegen Charlotte , Mestrez Fabienne , Faverly Daniel , Holz Serge , Taylor Stephen , Rossi Camelia 
Published: August 2021

AbstractWe present the case of a patient with three‐year indolent bilateral ureteral and perirenal masses. Clinical presentation, radiological context, and histopathological findings with detection of BRAFV600E mutation confirmed the diagnosis of Erdheim‐Chester disease (ECD). A review of current knowledge regarding diagnosis, clinical assessment, management, and treatment of ECD is also presented.
Immune thrombocytopenia in a 68‐year‐old woman after COVID‐19 vaccination
Authors: Kenney Ashley , Adhikari Anju 
Published: August 2021

AbstractThis case discusses a patient who presented with immune thrombocytopenia purpura (ITP) one week after COVID‐19 vaccination, introducing ITP as a consideration for a potential, but rare, adverse reaction to COVID‐19 vaccination.
Creutzfeldt‐Jakob disease with neuroleptic malignant syndrome
Authors: Čiauškaitė Julija , Puleikytė Ieva , Jesmanas Simonas , Jurkevičienė Giedrė , Vaitkus Antanas , Rastenytė Daiva 
Published: August 2021

AbstractCreutzfeldt‐Jakob disease (CJD) is a rare rapidly progressive fatal neurodegenerative disease. Neuroleptic malignant syndrome (NMS) is a complication of antipsychotic medications which may be used to treat neuropsychiatric symptoms of CJD. We present a case of a 51‐year‐ old woman with CJD who developed NMS after being prescribed quetiapine.
A novel SRY pathogenic variant from a 46,XY female harboring a nonsense point mutation (G to A) in position 293
Authors: Qin Shengfang , Wang Xueyan , Li Yunxing 
Published: August 2021

Abstract46,XY female is a genetic disorder characterized by gonad gender not consistent with chromosomal sex. The SRY gene mutation is a common cause of 46,XY reversal type 1 (OMIM: 400044). Peripheral blood was collected from a 46,XY female patient and her father. Sex chromosomes were confirmed by karyotype analysis and fluorescence in situ hybridization (FISH) detection of the specific probe of sex chromosomes with cultured lymphocytes. After extracting blood genomic DNA, SRY characteristic fluorescence peak was detected by quantitative fluorescence PCR (QF‐PCR) method. Whole exome was sequenced with NGS, and SRY gene was sequenced by Sanger sequencing, respectively. The chromosomes X and Y of the patient were confirmed by karyotype of 46,XY, and FISH specific probe of chromosome X and Y. SRY specific fluorescence peak was observed by QF‐PCR. The whole‐exome sequencing results showed chrY: 2655352(GRCh37): c.293G>A hemizygote mutation, confirmed by Sanger sequencing. The de novo mutation resulted in the mRNA encoding the tryptophan codon of 98 (UGG) change into a termination codon (UAG) (P.Trp98ter), and the translation process was terminated prematurely. The discovery of this novel mutation in the SRY gene helps elucidate the molecular mechanism of 46,XY female sex reversal and enriches such patients’ genetic mutation spectrum.
Supported Plasmonic Nanocatalysts for Hydrogen Production by Wet and Dry Photoreforming of Biomass and Biogas Derived Compounds: Recent Progress and Future Perspectives
Authors: Ćwieka Karol , Czelej Kamil , Colmenares Juan Carlos , Jabłczyńska Katarzyna , Werner Łukasz , Gradoń Leon 
Published: August 2021

AbstractNowadays, the pursuit of a circular economy and sustainability pushes the world's efforts toward less fossil fuel‐dependent energy production strategies. The sense of sustainability, thus, means searching for effective approaches involving ecological fuels, and processes with a little environmental concern. Approaches for utilization of such renewable resources like solar energy as a driving force, and biomass‐derived compounds as feedstocks for simultaneous hydrogen production as the most promising energy carrier, are currently gaining their momentum as the solutions for sustainable energy generation and tackling climate change. In this paper, we review the scientific advances in photocatalytic hydrogen production from biomass‐derived compounds via wet‐ and dry‐ photoreforming over metal‐loaded‐semiconductor photocatalysts. Based on the recent literature reports, we narrowed focus particularly to designing the state‐of‐the‐art photocatalysts which renders substantial enhancement of their performance possible via localized surface plasmon resonance effect.
Amyloidogenic Properties of Peptides Derived from the VHL Tumor Suppressor Protein
Authors: Kumar Vijay , Viswanathan Guru Krishna Kumar , Ralhan Krittika , Gazit Ehud , Segal Daniel 
Published: August 2021

AbstractThe von Hippel‐Lindau tumor suppressor protein (pVHL) is involved in maintaining cellular oxygen homeostasis through the regulated degradation of HIF‐α. The intrinsically disordered nature of pVHL makes it prone to aggregation that impairs its function, and this is further aggravated in mutant versions of the protein, thus promoting tumor development. By using in silico analysis, we predicted six peptide fragments from pVHL to be amyloidogenic. This was verified for two of the peptides by biophysical approaches, which demonstrated self‐assembly and formation of β‐sheet‐rich aggregates, which, under transmission electron microscopy, atomic force microscopy, and X‐ray diffraction, displayed typical fibrillar amyloid characteristics. These motifs may serve as proxies for exploring the nature of pVHL aggregation.
International remote collaboration enabled inaugural endoscopic sleeve gastroplasty in Japan
Authors: Dobashi Akira , Uno Kohei , Matsui Hiroaki , Furuhashi Hiroto , Futakuchi Toshiki , Kamba Shunsuke , Ono Shingo , Tamai Naoto , Watanabe Atsushi , Gostout Christopher J. , Sumiyama Kazuki 
Published: August 2021

AbstractObesity causes multiple conditions such as type 2 diabetes, cardiovascular disease, and so on, and an intervention is needed for controlling weight and improving metabolic syndrome. However, the effectiveness of lifestyle interventions and pharmacotherapy are restrictive for losing weight. Endoscopic sleeve gastroplasty (ESG) was developed as a new therapy, picking the best of both medication and surgery, less invasive and more effective. Recently, ESG is gradually spreading in Western countries, but there is Case report doesn't need conclusion/result for Japanese patients. We herein reported the first clinical case of ESG in Japan.Given the situation of the pandemic of COVID‐19, we could not invite a proctor from Western countries and receive the instruction of the device setting and maneuver face to face. Thus, we conducted the training for device setting, maneuver, and operation under a web‐based international remote collaboration. Eventually, we completed ESG without an adverse event. We could prove this web‐based proctor system was useful through the introduction of ESG in Japan. The international remote collaboration could become a new normal even in the endoscopy field post‐COVID‐19 era.
Comprehensive evaluation of the allelopathic potential of Elymus nutans
Authors: Quan Xiaolong , Qiao Youming , Chen Mengci , Duan Zhonghua , Shi Huilan 
Published: August 2021

AbstractElymus nutans has been widely planted together with other perennial grasses for rebuilding degraded alpine meadow atop the Qinghai‐Tibetan Plateau. However, the rebuilt sown pastures begin to decline a few years after establishing. One of the possible causes for the degradation of sown grassland may come from allelopathy of planted grasses. The purpose of this study was to examine allelopathic potential of Elymus nutans. Three types of aqueous extract from Elymus nutans and its root zone soil were prepared, and 5 highland crops and 5 perennial grasses were used as recipient plants. Elymus nutans exhibited strong allelopathic potential on germination and seedling growth of 5 crops, but different crops or perennial grasses respond to the extract differently. The pieces aqueous extract have stronger inhibition than whole plant extract and root zone soil extract. Hordeum vulgar var. nudum, Avena sativa, and Festuca sinensis were the most affected, while Chenopodium quinoa and Elymus sibiricus were the least affected. Elymus nutans presented less influence on Poa pratensis and Poa crymophylla than on Festuca sinensis. It is recommended that the species combination of mixture for restoration should be considered for allopathic effects on the coseeding to decrease the seeding rate ratio of Elymus nutans. The annual dicot crop seeds of Chenopodium quinoa and Brassica napus can be used as alternative subsequent crop for the seed field of Elymus nutans monoculture.
The evaluation and selection of core materials for microencapsulation: A case study with fragrances
Authors: Zhao Hongbin , Fei Xuening , Liang Chao , Xian Zhiming , Cao Lingyun , Yang Tingyu 
Published: August 2021

AbstractThis work focuses on the universal applicability of microencapsulation on core materials. From this point, nine different fragrance oils were selected as core materials, and the corresponding melamine resin shell microcapsules were prepared by a uniform process. According to characterization results, the microencapsulation shows good universality for most core materials, but their encapsulation efficiency (E%, 17.28%‐88.26%), particle size distribution (D50, 9.65‐33.82 μm) and optical micro‐morphology are significantly different. By analysing the influence of the interfacial tension (F), relative dielectric constant (ε), viscosity (τ), density (ρ) and refractive index (n) of the core materials on encapsulation, it was found that the F determines whether the core material is suitable, and f ≥ 1 is the basic condition for the core material to have the value of microencapsulation. Besides, the ε and n both can be used as auxiliary criteria, τ and ρ also influence the microencapsulation process. Based on these data, a “Dimensionless encapsulation number” was tentatively established, and the mathematical relation between it and corresponding E% was constructed, which could be applied as a semi‐empirical formula in practical work.
Transcriptome analysis of messenger RNA and long noncoding RNA related to different developmental stages of tail adipose tissues of sunite sheep
Authors: He Xige , Wu Rihan , Yun Yueying , Qin Xia , Chen Lu , Han Yunfei , Wu Jindi , Sha Lina , Borjigin Gerelt 
Published: August 2021

AbstractThe tail fat of sheep is the most typical deposited fat, and it can be widely used in human daily life, such as diet, cosmetics, and industrial raw materials. To understand the potential regulatory mechanism of different growth stages of tail fat in Sunite sheep, we performed high‐throughput RNA sequencing to characterize the long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression profiles of the sheep tail fat at the age of 6, 18, and 30 months. A total of 223 differentially expressed genes (DEGs) and 148 differentially expressed lncRNAs were found in the tail fat of 6‐, 18‐, and 30‐month‐old sheep. Based on functional analysis, we found that fat‐related DEGs were mainly expressed at 6 months of age and gradually decreased at 18 and 30 months of age. The target gene prediction analysis shows that most of the lncRNAs target more than 20 mRNAs as their transregulators. Further, we obtained several fat‐related differentially expressed target genes; these target genes interact with different differentially expressed lncRNAs at various ages and play an important role in the development of tail fat. Based on the DEGs and differentially expressed lncRNAs, we established three co‐expression networks for each comparison group. Finally, we concluded that the development of the sheep tail fat is more active during the early stage of growth and gradually decreases with the increase in age. The mutual regulation of lncRNAs and mRNAs may play a key role in this complex biological process.