bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poly-IgA Complexes and Disease Severity in IgA Nephropathy
Authors: Zhang Xue , Lv Jicheng , Liu Pan , Xie Xinfang , Wang Manliu , Liu Dan , Zhang Hong , Jin Jing 
Published: October 2021

Background and objectives
Poly-IgA immune complex formation and glomerular deposition play a key role in IgA nephropathy. Our study sought to develop a new methodology for one-step serologic detection of poly-IgA levels.

Design, setting, participants, & measurements
A novel ELISA method using recombinant CD89 as a “capturing” probe was established for detecting poly-IgA immune complex in plasma. We applied semiquantitative measurements of these poly-IgA indices in patients recruited at Peking University First Hospital who had IgA nephropathy or other kidney disease types, as compared with healthy controls. The longitudinal trend of the poly-IgA index and the association with pathologic parameters and treatment responses were evaluated. Finally, we analyzed the molecular composition of poly-IgA complexes in patients by mass spectrometry.

Results
Recombinant CD89–mounted ELISA plates specifically captured plasma poly-IgA. The levels of poly-IgA immune complex (26.7 [interquartile range (IQR) 17.1–42.6] U/ml) in IgA nephropathy were significantly higher than those in healthy controls (15.5 [IQR 10.7–20.0] U/ml; P<0.001) or in controls with non-IgA nephropathy disease (14.8 [IQR 10.5–21.9] U/ml; P<0.001). Higher levels of poly-IgA immune complex were associated with lower eGFR and worse kidney outcome. Accuracy parameters and concordant statistics showed good discrimination between IgA nephropathy and healthy controls based on poly-IgA index levels (area under the curve [AUC], 0.78; 95% confidence interval [95% CI], 0.72 to 0.83; P<0.001), significantly outperforming galactose-deficient IgA1 levels (AUC, 0.70; P=0.05). Corticosteroid and immunosuppressant treatments lowered poly-IgA indices. After a recombinant CD89–directed workflow in conjunction with mass spectrometry, we also analyzed the molecular composition of IgA immune complex in patients with IgA nephropathy.

Conclusions
Higher level of recombinant CD89–bound poly-IgA immune complex was associated with the severity of the disease and with treatment response to steroids and immunosuppressants.
Los retos de la enseñanza de Química en la pandemia de COVID-19: la metodología flipped classroom adaptada para el modo virtual en Brasil
Authors: Oliveira de Freitas Augusto Gonzaga , Brasil Irala Valesca , Maciel Bordin Daniela 
Published: October 2021

<p>La llegada de la pandemia COVID-19 impuso una serie de restricciones a escala global. Una nueva dinámica social se tuvo que adoptar en todo el mundo, en un intento por contener sus efectos. Las actividades docentes, como no podía ser de otra manera, también tuvieron que adaptarse a la realidad totalmente virtual, como consecuencia de la necesidad de distanciamiento social. Uno de los principales desafíos fue implementar la enseñanza virtual de manera que llegara a toda la comunidad académica. Desde entonces, se han adoptado diferentes metodologías para satisfacer las demandas de los más variados contextos. En este texto reportamos el uso de la metodología <em>flipped classroom</em> (que se traduce como clase invertida) en dos asignaturas de Química General, adaptadas a la modalidad virtual, en el contexto de una universidad federal brasileña. Se evaluó la percepción de los estudiantes sobre la metodología y el trabajo de tutoría desarrollado en uno de los grupos. Los resultados muestran que el aula invertida se puede adaptar a la realidad totalmente virtual, siendo favorecida de diversas formas por el trabajo de tutoría.</p><p> </p>
Diseño, aplicación y resultado de una estrategia de ludificación como actividad de cierre en clases de química
Authors: Lozano Lucia Oscar Raúl , Sánchez López de Andujar Alicia 
Published: October 2021

<p>Este trabajo se basa en la premisa de la falta de interés del alumnado por las ciencias, desencadenada en parte por las metodologías de enseñanza que utiliza el profesorado. Se profundiza en el concepto de ludificación (más conocido por el anglicismo de <em>gamificación</em>) y especialmente en la aplicación de actividades de tipo <em>Cuarto de Escape</em> en el entorno educativo. Se diseña una actividad de ludificación de este tipo, donde se trabajan conceptos que pertenecen al bloque de contenidos de “la materia” del currículo de Física y Química de 4º de ESO de España (15-16 años) con evaluación del resultado del juego por parte de los estudiantes y los docentes. Esta actividad trata conceptos que el alumnado ya ha estudiado anteriormente, por lo tanto, puede ser considerada como una actividad final, de cierre, o de evaluación de los conocimientos de la materia. En la actividad, además, se introduce la visión de una ciencia contextualizada respecto a la historia y a la actualidad (CTSA). </p>
Conocimientos del profesorado universitario sobre la enseñanza de la química con laboratorios remotos
Authors: Idoyaga Ignacio Julio , Vargas-Badilla Laura , Moya Cesar Nahuel , Montero-Miranda Eric , Maeyoshimoto Jorge Esteban , Capuya Fernando Gabriel , Arguedas-Matarrita Carlos 
Published: October 2021

<p>El trabajo presenta un estudio exploratorio cuyo objetivo es describir y caracterizar el conocimiento declarativo sobre la enseñanza de Valoración Ácido Base con Laboratorios Remotos de un grupo de nueve profesores de química de la Universidad de Buenos Aires. Estos dispositivos permiten realizar actividades experimentales reales remotamente en cualquier momento y desde cualquier lugar. La metodología incluyó el diseño de un cuestionario de preguntas abiertas. Para la revisión de datos se recorrió a algunos aspectos del análisis del contenido y a categorías generadas de acuerdo a los lineamientos de la teoría fundamentada. Los principales resultados mostraron que los profesores sostienen aproximaciones didácticas vinculadas a los protocolos tipo receta y a la mimesis, que consideran intuitivos a los Laboratorios Remotos y que priorizan la enseñanza de los contenidos conceptuales. A modo de conclusión puede decirse que los profesores conciben el trabajo con laboratorios remotos de manera similar a los trabajos prácticos tradicionales. Como perspectiva se plantea que queda inaugurada una línea de investigación, centrada en el conocimiento del profesorado, que deberá incorporar nuevas y variadas estrategias metodológicas. </p>
Magnetic parameters and palaeoclimate: A case study of loess deposits of North-East of Iran
Authors: Alimohammadian Habib , Haskouei Fereshteh Mahdipour , Sabouri Jafar 
Published: October 2021

Environmental magnetism techniques enable us to reconstruct paleoclimate conditions in some deposition such as losses. The magnetic properties of minerals are used as proxies for environmental changes. For this study, loess/paleosol sequence of Kolet section at Neka, north-east of Iran were magnetically investigated. We applied environmental magnetism methods, to reconstruct paleoclimate changes. We investigated relationship between paleoclimate changes and environmental magnetism proxies like magnetic susceptibility (?) variation. The laboratory techniques indicated the presence of main factor of magnetic property in loess/paleosol sequence, such as magnetite, maghemite and etc. We also estimated magnetically parameters (like SIRM, HIRM and etc.) to confirm concentrations of both aeolian and pedogenic particles versus variations of magnetic susceptibility enhancement. The ? values show prominent peaks for the three well developed soil and paleosol horizons, Recent Soil (S0), Upper Paleosol (S1) and Lower Paleosol (S2); which refer to warmer and wetter conditions. As result, we concluded that the increase/decreasing of magnetic susceptibility is coinciding with palaeosol/loess sequence, and probably with humid/arid conditions. Moreover, variations of magnetic susceptibility versus lithological column of Kolet section enabled us to recognize paleoclimatically periods known as interglacial/glacial cycles. The obtained magnetic data indicate that during over the past 50 ka, there have been at least two glacial/interglacial periods and since last 20 ka, there was no main glaciation occurrence, in the study area.
Micromechanical modeling of ultrasonic velocity for pore-structure and porosity characterization considering anisotropy in carbonate samples
Authors: Mena-Negrete Joseline , Valdiviezo-Mijangos Oscar C. , Coconi-Morales Enrique , Nicolás-López Rubén 
Published: October 2021

This work presents an approach to characterize the pore-structure and anisotropy in carbonate samples based on the Effective Medium Method (EMM). It considers a matrix with spheroidal inclusions which induce a transverse anisotropy. The compressional wave (VP), vertical (VSV) and horizontal (VSH) shear wave velocities are estimated taking into account parameters as characteristic length, frequency, angle of wave incidence, aspect ratio, mineralogy, and pore-filling fluid to predict pore shape in carbonates. Ranges of aspect ratios are shown to discriminate different pore types: intercrystalline, intergranular, moldic, and vuggy. The angle of wave incidence is a determinant parameter in the estimation of VP(0º, 45º, 90º), VSV(0º) and VSH(90º) to calculate dynamic anisotropic Young’s modulus (E33) and Poisson’s ratio (v31), as well as the Thomsen parameters, Epsilon, Gamma and Delta for quantification of the anisotropic pore-structure. The obtained results establish that the size, as well as the pore-structure, have a more significant impact on the elastic properties when the porosity takes values greater than 4% for the three frequencies, ultrasonic, sonic, and seismic. This investigation predicts the pore-structure and pore-size to improve characterization and elastic properties modeling of carbonate reservoirs. Validation of results includes porosity measurements and ultrasonic velocity data for different carbonate samples.
Epidemiology Incidence and Mortality Worldwide Common cancers in males and Their Relationship with the Human Development Index (HDI): An Ecological Study Updated in the World
Authors: Goodarzi Elham , Beiranvand Reza , Mosavi-Jarrahi Alireza , Naemi Hasan , Khazaei Zaher 
Published: October 2021

This article provides a status report on the global burden of common cancers in male in worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality.
Based on the results of cancer records in 2018, 9456418 cases of malignancy were recorded in males, with cancer (1368524 cases, 14.5 %), prostat cancer (1276106 cases, 13.5%), colorectal cancer(1026215 cases, 10.9%), stomach cancer(683754 cases, 7.2%) and liver cancer (596574 caces, 6.3%) were the five most common cancers in men worledwide. the total of deaths due to cancer in human in 2018 is 5385640. the five cases of death due to cancer in men worldwide are lung cancer (1184947 case, 22%), liver (548375 cases, 2.10%), stumach cancer (513555 cases, 9.5%), colorectal cancer (484224 case, 9%) and prostat cancer (358989 cases, 7.7 %). our resulth showed that there was a positive correlation between the incidence of lung cancer ( r= 0.629, p<0.0001), prostat cancer (r= 0.534, p<0.0001), colorectal cancer (r=0.745, p<0.0001) and stomach cancer (r=0.268, p<0.0001) with HDI index, while there was no significant relationship between liver cancer and the HDI (r=0.079, p>0.05).
the results also showed that there was a positive and significant correlation between mortality from lung cancer (r=0.632, p<0.0001) and colorectal (r=0.627, p<0.0001) with HDI, wereas this correlation was negative for prostate cancer (r=-0.187, p<0.05).
In-Vivo evaluation of implantable film containing Microencapsulated Sustained Releas Dexamethasone Sodium Phosphate
Authors: Abdul Ameer Mohammed Wajeah , Maraie Nidhal K. , Alwaeli Ali Mohsin 
Published: October 2021

Objective: This work involved in vivo evaluation of the previously prepared implantable film dosage form containing microencapsulated dexamethasone sodium phosphate (which is equivalent to 16 mg dexamethasone) and 4.4 mg pure dexamethasone sodium phosphate (which is equivalent to 4 mg dexamethasone) to be inserted at the inflamed areas to get suitable precise controlled release.
Methods: the animals used were 33 rates divided into 8 groups and the inflammation was induced by using 2.0% carrageenan solution to be injected intra-dorsally then the film was inserted locally and then sacrifying the animals on different time tables to take sample from the site of inflammation for 5 months and examined under electron microscope.
Results: the results showed that the prepared implantable film had immediate anti-inflammatory effect upon insertion at the inflamed tissue and its action continued effectively for five months.
Conclusion: this work proved that implantable film containing dexamethasone should be used after surgery of joint replacement or any other surgery site as alternative to the applied regimen of giving IM injection of the commercially available 10mg dexamethasone intraoperatively and a second 10 mg within 24-hour postoperatively to reduce edema and pain followed by oral dexamethasone 0.5 mg on daily based till complete recovery which may last for 5 months or more and subject the patients to the serious systemic effects. The application of the implanted film therapy may reduce the rejection of the body to the replaced joint or other replacement surgery and improves patient compliance.
Satisfaction with focused and risk approach antenatal care services among pregnant women attending primary health care centers in Erbil city
Authors: Al-Khayat Amina , Al-Hadithi Tariq S 
Published: October 2021

Objectives: Client satisfaction is essential for further improvement of the quality of health care. This study aimed to assess the satisfaction with focused and risk approach antenatal care services among pregnant women in Erbil city of Iraq.
Methods: This cross-sectional study was conducted at two primary health care centers in Erbil city, one provides focused antenatal care services and the other provides risk approach antenatal care services. A convenience sample of 300 pregnant women (150 pregnant women from each center) participated in the study. An especially designed questionnaire was used for data collection.
Results: Around 61% of women attending focused antenatal care were very satisfied with care while only 12 % of women attending risk approach standard antenatal care were very satisfied with antenatal care (P <0.001). The perceived causes of dissatisfaction included crowding in the clinic in the morning, unfavorable waiting area and unavailability of daily sonar exam. A significantly higher proportion (P<0.001) of the high level of satisfaction (78%) was reported among women attending focused antenatal care than risk approach standard antenatal care (38%).
Conclusion: Women attending focused antenatal care were highly satisfied with services provided to them while those attending risk approach standard antenatal care were less satisfied with services. Further improvement of focused antenatal care services in Erbil is required.
Diagnosis of a tracheal tear by use of an oxygen analyzer in a dog with cervical trauma
Authors: Walters Kate L. , Knight Rebekah C. 
Published: October 2021

Abstract

CASE DESCRIPTION
A 7.75-year-old sexually intact male Welsh Terrier was examined because of cervical soft tissue wounds and an inability to maintain hemoglobin oxygen saturation without oxygen supplementation following a dog attack.

CLINICAL FINDINGS
A 2-cm-long penetrating wound that extended into a large open pocket was identified on the left ventral aspect of the dog’s neck. The dog was anesthetized and underwent advanced imaging, the findings of which suggested that the trachea was intact. However, when the cuff of the endotracheal tube was deflated during the dog’s recovery from anesthesia, sudden oxygen desaturation occurred. Given no radiographic signs of deteriorating lung injury, a tracheal tear was suspected. For rapid confirmation of a tracheal tear, without the need for additional advanced imaging, the oxygen concentration at the skin wound was investigated by use of an oxygen analyzer. When the dog was breathing 100% oxygen, the analyzer identified a higher oxygen concentration at the edge of the penetrating wound, compared with the concentration of oxygen in room air; the leakage of oxygen-rich gases from the airway through the wound confirmed the presence of a tracheal tear, immediately indicating the need for surgical exploration and repair.

TREATMENT AND OUTCOME
Surgical repair of the tracheal tear with a left sternothyroideus muscle flap was successfully performed.

CLINICAL RELEVANCE
For this dog, an oxygen analyzer was used to confirm the presence of a tracheal tear, suggesting that application of an oxygen analyzer may be useful in the emergency management of neck trauma cases.
Validating mid-upper arm circumference (MUAC) cut off points as an indicator of nutritional status among nine tribal populations of India
Authors: Kshatriya Gautam K. , Chakraborty Raja , Mondal Nitish , Bose Kaushik 
Published: October 2021

Mid-upper arm circumference (MUAC) is an alternative anthropometric measurement to assess undernutrition but a universally accepted cut-off is yet to be established. The objectives of the present study are to determine whether the proposed sex-specific global cut-offs are suitable across several tribes in India. This cross-sectional study was conducted among nine tribal populations in India (1046 males, 1087 females). Weight, height and MUAC values were obtained, and body mass index (BMI) was calculated. The BMI cut-off (<18.5 kg/m2) was used to determine chronic energy deficiency (CED). The ROC Curve analyses of binomial logistic regression for MUAC versus CED revealed optimal cut-off point of MUAC as 23.8 cm (in males) and 21.8 cm (in females). MUAC cut-offs were similar in females, relative to males, in all tribes. Males with MUAC<24cm and females with MUAC<22 encompassed significantly higher numbers of CED than those with MUAC≥24 and ≥22 cm, respectively (χ2-value males: 254.9, p<0.001; females: 493.60, p<0.01). A single cut off point of MUAC may not be universally applicable for diverse populations and both sexes as well. It seemed that there is no alternative than to undertake further validation studies in various populations before using the MUAC cut off to identify undernourished or CED condition.
Managing Nature-Based Tourism in Protected Karst Area Based on Tourism Carrying Capacity Analysis
Authors: Putri Indra A.S.L.P. , Ansari Fajri 
Published: October 2021

Abstract
Nature-based tourism relies on the beauty of nature to maintain sustainability and attraction. However, karst environment is vulnerable to disturbance due to tourism activity. This study, therefore, aims to analyze the social, ecological, physical, real, and effective carrying capacity of Pattunuang Assue Nature Tourism Object, Bantimurung Bulusaraung National Park. Data were collected through field measurement, observation, and interviews. Data of visitors’ favorite spot and its size were measured through observation and field measurement. Visitors’ perceptions related to the destination, including their duration activities were collected through interviews. It was further collected by observing the various spots of activity, and measuring the area of restrictive factors such as physical (number of rainy days), biotic (vegetation diversity at tree level, the diversity of birds during the busy visiting hours, the initial period of the Tarsius fuscus’ birth). We also observe the equipment and infrastructure of the destination and collected data related to management through interviews with the managers. This study reveals various carrying capacity value which can be used as an option for the managers to choose the best way to manage destination in the right way. The result showed that particular activities exceeded carrying capacity but other activities far below their carrying capacity value. The study furthermore discusses how to deal with numerous activities. It also suggests an increase in the number of visitors by considering their ecological characteristics and management capacity.
Anxiety and depression in tyrosine hydroxylase deficiency: a case report
Authors: Alarcon Belen Garcia , Walterfang Mark , Thevathasan Wesley 
Published: October 2021

Background:
Tyrosine hydroxylase (TH) deficiency is a very rare genetic disorder of monoamine synthesis which - alongside Guanosine triphosphate (GTP) cyclohydrolase deficiency - is one of the metabolic dopa-responsive dystonias. These disorders classically present as a dystonia with onset in adolescence which is non-progressive and responds to standard dopaminergic treatment: however, little is known about the relationship between TH deficiency and psychiatric illness.

Case Presentation:
We describe a case of a young woman who, in the absence of any heralding psychiatric symptomatology of any nature, developed a severe and limiting panic disorder at around the time of onset of her movement disorder in the setting of TH deficiency, which impacts dopamine synthesis.

Conclusion:
Neurometabolic disorders that affect neurotransmitter function frequently present with psychiatric symptomatology and can provide models for understanding some frequently presenting psychiatric illnesses such as depression and anxiety. We discuss the interplay between the dopaminergic and serotonergic systems, and how an ostensibly dopaminergic disorder could produce what has long been understood to be a serotonergically-driven anxiety syndrome.
Analisis Komentar Followers terhadap Identitas Gender Beauty Influencer Laki-Laki di Instagram
Authors: Novitaria Valent , Rusdi Farid 
Published: October 2021

A phenomenon that starts to become popular in social media, especially Instagram, is becoming a content creator that focuses on beauty, also known as beauty influencer. Beauty influencers are identical to pretty and feminine concepts, but as the time goes by, male beauty influencers started to emerge as well. This created positive and negative opinions in society, especially about their gender identities. In Indonesia, genderless issue starts to attract public attention. Many people started to question the stiff gender categories by expressing their opinions regarding this phenomenon. This research was conducted with qualitative approach with Teun Van Dijk text analysis method. Data collection was conducted by observations, interviews, and documentations. Based on analysis, it is found that changes in society may affect an individual's social system, attitude, value, and behavioural pattern. People in the past recognise that men are masculine and women are feminine. Nowadays, gender limitation line is getting thinner, prioritising human rights. This proves that the perception of gender identities in the society are slowly changing.Salah satu fenomena yang marak di media sosial khususnya Instagram adalah menjadi content creator di bidang kecantikan atau yang biasa disebut dengan beauty influencer.Beauty influencer identik dengan konsep cantik dan feminine. Seiring perkembangan zaman, saat ini ada pula beauty influencer berjenis kelamin laki-laki. Hal tersebut memunculkan berbagai opini positif maupun negatif dalam masyarakat, khususnya mengenai identitas gender yang mereka tampilkan. Di Indonesia, isu genderless semakin menjadi perhatian publik. Orang-orang mulai mempertanyakan kategori gender yang kaku dan mengemukakan berbagai pendapat atas fenomena ini. Penelitian ini dilakukan dengan pendekatan penelitian kualitatif menggunakan teknik analisis wacana Teun Van Dijk. Metode pengumpulan data dilakukan dengan menggunakan observasi, wawancara, dan dokumentasi. Berdasarkan hasil analisis dapat diketahui bahwa adanya perubahan dalam masyarakat dapat mempengaruhi sistem sosial, sikap, nilai, dan pola perilaku individu. Masyarakat pada zaman dulu memiliki persepsi bahwa pria harus maskulin dan perempuan feminin. Sementara zaman sekarang, garis pembatasan gender semakin tipis dan lebih mengutamakan hak manusia. Hal tersebut membuktikan bahwa persepsi mengenai identitas gender yang ada dalam masyarakat sudah perlahan-lahan berubah.