bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secondary parkinsonism caused by chronic subdural hematomas owing to compressed cortex and a disturbed cortico–basal ganglia–thalamocortical circuit: illustrative case
Authors: Fukumura Masao , Murase Sho , Kuroda Yuzo , Nakazawa Kazutomo , Gon Yasufumi 
Published: June 2021

BACKGROUND
Chronic subdural hematoma (CSDH) is a commonly encountered condition in neurological and neurosurgical practice, but the presence of concomitant parkinsonism is extremely rare. Basal ganglia disturbance is a well-known underlying mechanism; however, few cases present with cerebral cortex compression as the cause of symptoms.

OBSERVATIONS
A 52-year-old man was referred to the authors’ hospital with a 5-week history of gait disturbance and suspected Parkinson’s disease. Neurological examination revealed a mask-like face, stooped posture, left-predominant rigidity, and postural instability. The authors initiated dopamine agonist administration, and brain magnetic resonance imaging (MRI) was scheduled. One week later, MRI showed bilateral CSDHs. The hematomas markedly compressed the bilateral cerebral cortex, whereas the midbrain and basal ganglia structures were intact. The patient underwent burr hole drainage and was discharged after 9 days without sequelae.

LESSONS
CSDH can cause parkinsonism by compressing the cerebral cortex, which is a part of the cortico–basal ganglia–thalamocortical circuit. Surgery leads to positive outcomes, as illustrated by this case, in which cerebral cortex compression caused parkinsonism.
GAMBARAN KEBIASAAN MEROKOK PENDUDUK DI INDONESIA
Authors: SATRIAWAN DODI 
Published: June 2021

Merokok merupakan kebiasaan yang dapat merusak kesehatan dan dapat menyebabkan berbagai macam penyakit yang dapat berakibat kepada terjadinya morbiditas maupun mortalitas dimana Angka Kematian Kasar (CDR) merupakan salah satu parameter mortalitas. Tujuan dari penelitian ini adalah untuk mengetahui gambaran Angka Kematian Kasar di Indonesia serta gambaran penduduk yang merokok di Indonesia menurut jenis kelamin, kegiatan seminggu terakhir, keluhan kesehatan dan kebiasaan merokok satu bulan terakhir dan sebelum satu bulan terakhir. Data yang digunakan dalam penelitian ini adalah data SUSENAS Maret 2019 dan analisis yang digunakan adalah analisis deskriptif. Dari hasil penelitian dapat dilihat bahwa penurunan CDR Indonesia lebih cepat dibandingkan Dunia. Dari hasil olah data SUSENAS tahun 2019 diketahui bahwa mayoritas kebiasaan merokok dilakukan oleh laki-laki dan hanya sebagian kecil perempuan, hanya sebagian kecil saja dari perokok aktif yang mengalami keluhan kesehatan namun terjadi kecenderungan peningkatan persentase keluhan kesehatan bagi penduduk yang punya kebiasaan merokok yang dilakukan setiap hari sebelum satu bulan terakhir (periode pencacahan SUSENAS), serta terdapat sejumlah perokok aktif yang merokok setiap hari dari kalangan penduduk yang berstatus mengurus rumah tangga.
The Analysis of Factors Affecting Preparation Level for the Industry 4.0 Era in the COVID-19 Pandemic on Employees in DKI Jakarta
Authors: Setiadi Rianti , Franky Franky 
Published: June 2021

This study analyses significant factors affecting the level of preparation for the industry 4.0 era related to anxiety about the COVID-19 pandemic on employees in DKI Jakarta. Apart from being influenced by the anxiety of the COVID-19 pandemic, the level of preparation for the industry 4.0 is also differentiated by gender, age, education, marital status, decreasing income, and loyalty. Therefore, companies can arrange the planning related to preparing the industry 4.0 during the COVID-19 pandemic if those factors have been figured out. This study used a quantitative method, and the population of this study is full-time employees in DKI Jakarta. The sample was selected by using the snowball sampling technique distributed to 12 companies in DKI Jakarta. The distribution was conducted through the WhatsApp application for a month, and it was gained 228 respondents. Snowball sampling technique used in correlation with the implementation of large-scale social restrictions caused by COVID-19 pandemic. The data analysis used a multiple linear regression model. The results show that factors affecting the level of employees’ preparation in DKI Jakarta for industry 4.0 related to the anxiety of the COVID-19 pandemic are loyalty and a decrease in income.
Enhancing Professional Practice and Professionalism among Canadian Rural Paramedics
Authors: Grenier Mathieu , van Vuuren Julia , Spelten Evelien 
Published: June 2021

Introduction The scope of paramedic practice is being redefined and expanded. Professional development and clinical expertise are not only necessary for paramedics to perform their clinical functions and operational responsibilities, they are at the very core of their professionalisation. Professionalisation is a complex process, and the degree to which it can accomplished will impact society's perception of the profession – and its trust in it – for years to come. This study investigated ways to enhance professional practice, from the point of view of the main healthcare providers in a rural area of Ontario, Canada. Methods A qualitative analysis informed by action research methodology was used. The research design was staged and consisted of focus groups and a World Café. The data were coded and organised into themes, using thematic analysis, and were triangulated with the literature. Results Three key themes emerged from the World Café and focus group conversations including current enablers of professionalisation; system components that promote professionalism; and community of practice to support professional development and clinical expertise. Conclusion Paramedic practice is evolving. This should be reflected in clinical practice and education, and more paramedic-led research. Paramedic training may need to move from the college to the university environment to reflect equal standing with colleagues in the broader healthcare system. This study shows strong motivation among paramedics and management to enhance professional practice and professionalism. To achieve this, a culture of trust, developing engagement and communication strategies and establishing a community of practice are crucial.
Alopecia Areata in Down Syndrome: Treatment With Systemic Steroid
Authors: Hye Mohammad A 
Published: June 2021

Down syndrome is the most common congenital abnormality affecting numerous organs including skin and is associated with an increased incidence of alopecia areata. Down syndrome is an extensively researched condition but alopecia areata seldom received appropriate attention. Alopecia areata in Down syndrome is very refractory to treatment and there are only few relevant published data are available in medical literature. Two cases of alopecia areata associated with Down syndrome are presented here. These patients were treated with a short course of prednisolone; a good result was observed in one case but that was unsatisfactory in another case. The disease relapses in both cases within few months of treatment.
CBMJ 2016 July: Vol. 05 No. 02 P: 43-46
50 years Institute for Nuclear Research: exploring the high-energy universe
Authors: Spiering C 
Published: June 2021

Abstract
This article is an attempt to review 50 years of high-energy cosmic particle physics at the Institute for Nuclear Research of the Russian Academy of Sciences. It is written by an outsider whose scientific career, to a large part, was shaped by collaborating with INR scientists in the late 1980s and 1990s. The review covers the fields of cosmic-ray, gamma-ray, and high-energy neutrino physics. The main focus will be on INR’s large facilities in the Baksan Valley and at Lake Baikal. Research at these facilities is accompanied by participation in top experiments at different places around the world: recently, the Telescope Array in the USA and the LHAASO detector in China.
Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation
Authors: Pinto Sneha M. , Kim Hera , Subbannayya Yashwanth , Giambelluca Miriam S. , Bösl Korbinian , Ryan Liv , Sharma Animesh , Kandasamy Richard K. 
Published: June 2021

Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage differentiation protocols exist, with phorbol 12-myristate-13-acetate (PMA) being the most commonly used and accepted method. However, the concentrations and duration of PMA treatment vary widely in the published literature and could affect the probed phenotype, however their effect on protein expression is not fully deciphered. In this study, we employed a dimethyl labeling-based quantitative proteomics approach to determine the changes in the protein repertoire of macrophage-like cells differentiated from THP-1 monocytes by three commonly used PMA-based differentiation protocols. Employing an integrated network analysis, we show that variations in PMA concentration and duration of rest post-stimulation result in downstream differences in the protein expression and cellular signaling processes. We demonstrate that these differences result in altered inflammatory responses, including variation in the expression of cytokines upon stimulation with various Toll-like receptor (TLR) agonists. Together, these findings provide a valuable resource that significantly expands the knowledge of protein expression dynamics with one of the most common in vitro models for macrophages, which in turn has a profound impact on the immune as well as inflammatory responses being studied.
Assessing Nigrostriatal Dopaminergic Pathways via 123I-FP-CIT SPECT in Dementia With Lewy Bodies in a Psychiatric Patient Cohort
Authors: Hansen Niels , Lange Claudia , Timäus Charles , Wiltfang Jens , Bouter Caroline 
Published: June 2021

Background(123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortro- pane single photon emission computed tomography (123I-FP-CIT SPECT) was validated to distinguish Alzheimer’s dementia from dementia with Lewy Bodies (DLB) by European medical agencies. Little evidence exists that validates 123 I-FP-CIT SPECT as a supplementary method to diagnose probable DLB in a psychiatric cohort of patients with psychiatric symptomatology and suspected DLB. We aim to elucidate differences in the clinical phenotype of DLB between those patients with and those without a positive 123 I-FP-CIT SPECT indicating a nigrostriatal deficit.MethodsTo investigate this, we included 67 patients from the Department of Psychiatry and Psychotherapy at University Medical Center Göttingen (UMG) in our study who had undergone 123I-FP-CIT SPECT in the Department of Nuclear Medicine (UMG) by evaluating their patient files.Results55% with a positive-123I-FP-CIT SPECT and probable DLB after the 123I-FP-CIT SPECT exhibited psychiatric features. The number of probable DLB patients in those exhibiting psychiatric symptoms was higher post-123I-FP-CIT SPECT than pre-123I-FP-CIT SPECT assessed cross-sectionally over a 6-year period (p &lt; 0.05). In addition, prodromal DLB and prodromal DLB patients with a psychiatric-phenotype yielded higher numbers post-123I-FP-CIT SPECT than pre-123I-FP-CIT SPECT (p &lt; 0.05). Furthermore, we discovered no phenotypical differences between those DLB patients with a positive and those with a negative 123I-FP-CIT SPECT. 123I-FP-CIT SPECT-positive DLB patients in our psychiatric cohort revealed a psychiatric onset more often (52%); DLB was less often characterized by an MCI onset (26%) (p &lt; 0.005).ConclusionsOur findings support 123I-FP-CIT SPECT as an adjuvant tool for improving the diagnosis of probable DLB and prodromal DLB in a cohort of psychiatric patients with often concomitant psychiatric symptomatology. The psychiatric-onset is more frequent than an MCI-onset in DLB patients presenting nigrostriatal dysfunction, giving us an indication of the relevance of deep clinical phenotyping in memory clinics that includes the assessment of psychopathology.
Multiparametric MRI for Characterization of the Basal Ganglia and the Midbrain
Authors: Schneider Till M. , Ma Jackie , Wagner Patrick , Behl Nicolas , Nagel Armin M. , Ladd Mark E. , Heiland Sabine , Bendszus Martin , Straub Sina 
Published: June 2021

ObjectivesTo characterize subcortical nuclei by multi-parametric quantitative magnetic resonance imaging.Materials and Methods:The following quantitative multiparametric MR data of five healthy volunteers were acquired on a 7T MRI system: 3D gradient echo (GRE) data for the calculation of quantitative susceptibility maps (QSM), GRE sequences with and without off-resonant magnetic transfer pulse for magnetization transfer ratio (MTR) calculation, a magnetization−prepared 2 rapid acquisition gradient echo sequence for T1mapping, and (after a coil change) a density-adapted 3D radial pulse sequence for23Na imaging. First, all data were co-registered to the GRE data, volumes of interest (VOIs) for 21 subcortical structures were drawn manually for each volunteer, and a combined voxel-wise analysis of the four MR contrasts (QSM, MTR, T1,23Na) in each structure was conducted to assess the quantitative, MR value-based differentiability of structures. Second, a machine learning algorithm based on random forests was trained to automatically classify the groups of multi-parametric voxel values from each VOI according to their association to one of the 21 subcortical structures.ResultsThe analysis of the integrated multimodal visualization of quantitative MR values in each structure yielded a successful classification among nuclei of the ascending reticular activation system (ARAS), the limbic system and the extrapyramidal system, while classification among (epi-)thalamic nuclei was less successful. The machine learning-based approach facilitated quantitative MR value-based structure classification especially in the group of extrapyramidal nuclei and reached an overall accuracy of 85% regarding all selected nuclei.ConclusionMultimodal quantitative MR enabled excellent differentiation of a wide spectrum of subcortical nuclei with reasonable accuracy and may thus enable sensitive detection of disease and nucleus-specific MR-based contrast alterations in the future.
Validation of the Clinical Treatment Score Post–Five Years in Breast Cancer Patients for Predicting Late Distant Recurrence: A Single-Center Investigation in Korea
Authors: Lee Jun-Hee , Lee Se Kyung , Chae Byung Joo , Yu Jonghan , Lee Jeong Eon , Kim Seok Won , Nam Seok Jin , Ryu Jai Min 
Published: June 2021

BackgroundEndocrine therapy is administered to hormone-positive breast cancer patients to prevent distant metastasis. It is important to evaluate the risk of recurrence and to determine which patients are viable candidates for such treatment because hormone therapy has side effects that can include postmenopausal symptoms. The Clinical Treatment Score post–five years (CTS5), a simple tool for identifying candidates for endocrine therapy, was recently introduced; however, CTS5 only has been applied in validation studies with postmenopausal women. We aimed to validate CTS5 among premenopausal breast cancer patients.MethodsWe identified patients treated between 1994 and 2014 at Samsung Medical Center in Seoul, Korea, and followed their treatment outcomes for more than 60 months after surgery using clinicopathologic parameters. According to menopausal status, we divided the study population into two groups: pre- and postmenopausal women. After calculating CTS5 values based on some parameters, we stratified the rate of late distant recurrence (DR) and analyzed the correlation between CTS5 value and late DR by risk.ResultsAmong 16,904 patients treated surgically for breast cancer, 2,605 with hormone receptor–positive breast cancer who received endocrine therapy were included. Of these, 1,749 (67.14%) patients were premenopausal women, and the median age was 44.00 years. When categorizing study participants according to CTS5-related risk for late DR, 86.79% were categorized as low risk, 5.95% were categorized as intermediate risk, and 7.26% were categorized as high risk. The annual rate of DR was 1.41% for those in the present study and was similar between pre- and postmenopausal participants (1.40 vs. 1.42). Distant metastasis-free survival was not different between the two groups (hazard ratio: 0.817, 95% confidence interval [CI]: 0.547–1.221). The area under the receiver operating characteristic curve at 10 years for premenopausal and postmenopausal patients was 61.75 (95% CI: 52.97–70.53) and 72.71 (95% CIs: 63.30–82.12), respectively.ConclusionsAlthough CTS5 was able to predict late DR, it should be applied with caution in premenopausal women. A CTS5 calculator for premenopausal women might be needed to not underestimate the risk of recurrence in Korea.
Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
Authors: Li Changxiang , Sui Conglu , Wang Wei , Yan Juntang , Deng Nan , Du Xin , Cheng Fafeng , Ma Xiaona , Wang Xueqian , Wang Qingguo 
Published: June 2021

Background: Baicalin (BCL), a candidate drug for ischemic stroke, has been indicated to protect neurons by promoting brain-derived neurotrophic factor (BDNF). However, the cellular source of BDNF release promoted by baicalin and its detailed protective mechanism after ischemia/reperfusion remains to be studied. The aim of this study was to investigate the neuroprotective mechanisms of baicalin against oxygen–glucose deprivation/reoxygenation (OGD/R) in a neuron–astrocyte coculture system and to explore whether the BDNF-TrkB pathway is involved.Methods and Results: A neuron–astrocyte coculture system was established to elucidate the role of astrocytes in neurons under OGD/R conditions. The results demonstrated that astrocytes became reactive astrocytes and released more BDNF in the coculture system to attenuate neuronal apoptosis and injury after OGD/R. BCL maintained the characteristics of reactive astrocytes and obviously increased the expression of cyclic AMP response element-binding protein (CREB) and the levels of BDNF in the coculture system after OGD/R. To further verify whether BDNF binding to its receptor tyrosine kinase receptor B (TrkB) was required for the neuroprotective effect of baicalin, we examined the effect of ANA-12, an antagonist of TrkB, on NA system injury, including oxidative stress, inflammation, and apoptosis induced by OGD/R. The results showed that treatment of NA systems with ANA-12 significantly attenuated the neuroprotection of BCL. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathways are two important downstream cascades of signaling pathways activated by BDNF binding to TrkB. We investigated the expressions of TrkB, PI3K, Akt, MAPK, and ERK. The results demonstrated that baicalin significantly increased the expressions of TrkB, PI3K/AKT, and MAPK/ERK.Conclusion: The neuroprotective effects of baicalin against oxidative stress, inflammation, and apoptosis were improved by astrocytes, mainly mediated by increasing the release of BDNF and its associated receptor TrkB and downstream signaling regulators PI3K/Akt and MAPK/ERK1/2.
Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction
Authors: Borghi-Silva Audrey , Goulart Cassia da Luz , Carrascosa Cláudia R. , Oliveira Cristino Carneiro , Berton Danilo C. , de Almeida Dirceu Rodrigues , Nery Luiz Eduardo , Arena Ross , Neder J. Alberto 
Published: June 2021

BackgroundRespiratory muscle unloading through proportional assist ventilation (PAV) may enhance leg oxygen delivery, thereby speeding off-exercise oxygen uptake (V.⁢O2) kinetics in patients with heart failure with reduced left ventricular ejection fraction (HFrEF).MethodsTen male patients (HFrEF = 26 ± 9%, age 50 ± 13 years, and body mass index 25 ± 3 kg m2) underwent two constant work rate tests at 80% peak of maximal cardiopulmonary exercise test to tolerance under PAV and sham ventilation. Post-exercise kinetics of V.⁢O2, vastus lateralis deoxyhemoglobin ([deoxy-Hb + Mb]) by near-infrared spectroscopy, and cardiac output (QT) by impedance cardiography were assessed.ResultsPAV prolonged exercise tolerance compared with sham (587 ± 390 s vs. 444 ± 296 s, respectively; p = 0.01). PAV significantly accelerated V.⁢O2 recovery (τ = 56 ± 22 s vs. 77 ± 42 s; p &lt; 0.05), being associated with a faster decline in Δ[deoxy-Hb + Mb] and QT compared with sham (τ = 31 ± 19 s vs. 42 ± 22 s and 39 ± 22 s vs. 78 ± 46 s, p &lt; 0.05). Faster off-exercise decrease in QT with PAV was related to longer exercise duration (r = −0.76; p &lt; 0.05).ConclusionPAV accelerates the recovery of central hemodynamics and muscle oxygenation in HFrEF. These beneficial effects might prove useful to improve the tolerance to repeated exercise during cardiac rehabilitation.
Adaptation and Psychometric Evaluation of the Chinese Counseling Competencies Scale-Revised
Authors: Xia Wei , Li William Ho Cheung , Liang Tingna , Luo Yuanhui , Ho Laurie Long Kwan , Cheung Ankie Tan , Song Peige 
Published: June 2021

Objectives: This study conducted a linguistic and psychometric evaluation of the Chinese Counseling Competencies Scale-Revised (CCS-R).Methods: The Chinese CCS-R was created from the original English version using a standard forward-backward translation process. The psychometric properties of the Chinese CCS-R were examined in a cohort of 208 counselors-in-training by two independent raters. Fifty-three counselors-in-training were asked to undergo another counseling performance evaluation for the test-retest. The confirmatory factor analysis (CFA) was conducted for the Chinese CCS-R, followed by internal consistency, test-retest reliability, inter-rater reliability, convergent validity, and concurrent validity.Results: The results of the CFA supported the factorial validity of the Chinese CCS-R, with adequate construct replicability. The scale had a McDonald's omega of 0.876, and intraclass correlation coefficients of 0.63 and 0.90 for test-retest reliability and inter-rater reliability, respectively. Significantly positive correlations were observed between the Chinese CCS-R score and scores of performance checklist (Pearson's γ = 0.781), indicating a large convergent validity, and knowledge on drug abuse (Pearson's γ = 0.833), indicating a moderate concurrent validity.Conclusion: The results support that the Chinese CCS-R is a valid and reliable measure of the counseling competencies.Practice implication: The CCS-R provides trainers with a reliable tool to evaluate counseling students' competencies and to facilitate discussions with trainees about their areas for growth.
Tunable Goos-Hänchen Shift Surface Plasmon Resonance Sensor Based on Graphene-hBN Heterostructure
Authors: Liu Zihao , Lu Fangyuan , Jiang Leyong , Lin Wei , Zheng Zhiwei 
Published: June 2021

In this paper, a bimetallic sensor based on graphene-hexagonal boron nitride (hBN) heterostructure is theoretically studied. The sensitivity of the sensor can be improved by enhancing the Goos–Hänchen (GH) shift in the infrared band. The theoretical results show that adjusting the Fermi level, the number of graphene layers and the thickness of hBN, a GH shift of 182.09 λ can be obtained. Moreover, sensitivity of 2.02 × 105 λ/RIU can be achieved with monolayer graphene, the thickness of gold layer is 20 nm, silver layer is 15 nm, and the hBN thickness of 492 nm. This heterogeneous infrared sensor has the advantages of high sensitivity and strong stability. The research results will provide a theoretical basis for the design of a new high-sensitivity infrared band sensor.