bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma
Authors: Yin Zixun , Zhang Ya , Wang Xin 
Published: July 2021

AbstractB-cell non-Hodgkin lymphoma (B-NHL) is a group of heterogeneous disease which remains incurable despite developments of standard chemotherapy regimens and new therapeutic agents in decades. Some individuals could have promising response to standard therapy while others are unresponsive to standard chemotherapy or relapse after autologous hematopoietic stem-cell transplantation (ASCT), which indicates the necessity to develop novel therapies for refractory or relapsed B-NHLs. In recent years, a novel cell therapy, chimeric antigen receptor T-cell therapy (CAR-T), was invented to overcome the limitation of traditional treatments. Patients with aggressive B-NHL are considered for CAR-T cell therapy when they have progressive lymphoma after second-line chemotherapy, relapse after ASCT, or require a third-line therapy. Clinical trials of anti-CD19 CAR-T cell therapy have manifested encouraging efficacy in refractory or relapsed B-NHL. However, adverse effects of this cellular therapy including cytokine release syndrome, neurotoxicity, tumor lysis syndrome and on-target, off-tumor toxicities should attract our enough attention despite the great anti-tumor effects of CAR-T cell therapy. Although CAR-T cell therapy has shown remarkable results in patients with B-NHL, the outcomes of patients with B-NHL were inferior to patients with acute lymphoblastic leukemia. The inferior response rate may be associated with physical barrier of lymphoma, tumor microenvironment and low quality of CAR-T cells manufactured from B-NHL patients. Besides, some patients relapsed after anti-CD19 CAR-T cell therapy, which possibly were due to limited CAR-T cells persistence, CD19 antigen escape or antigen down-regulation. Quite a few new antigen-targeted CAR-T products and new-generation CAR-T, for example, CD20-targeted CAR-T, CD79b-targeted CAR-T, CD37-targeted CAR-T, multi-antigen-targeted CAR-T, armored CAR-T and four-generation CAR-T are developing rapidly to figure out these deficiencies.
Development of the Departmental Climate around Teaching (DCaT) survey: neither psychological collective climate nor departmental collective climate predicts STEM faculty’s instructional practices
Authors: Shi Lu , Stains Marilyne 
Published: July 2021

Abstract
Background
Investigations into drivers and barriers to the uptake of learner-centered instructional practices in STEM courses have identified the climate within a department as a potential influential factor. However, few studies have explored the relationship between adoption of learner-centered instructional practices and departmental climate around teaching. Moreover, surveys that have been designed to measure climate around teaching have been focused on measuring individual faculty member’s description of their colleagues’ perceptions of the climate within their department (psychological collective climate) and ignored whether there was a consensus among respondents within the same department on these descriptions. This latter measure (departmental collective climate) is best aligned with the definition of organizational climate. There is thus a need to explore whether departmental climate measured at the individual or collective level relate to the use of learner-centered instructional practices.

Results
This study demonstrates that the Departmental Climate around Teaching (DCaT) survey provides valid and reliable data that can be used to measure psychological collective climate within a STEM department. Analysis of the 166 faculty members who responded to the survey indicated that (1) four different types of psychological collective climate existed among our population and (2) multiple types could be present within the same STEM department. Moreover, it showed that measuring departmental collective climate is challenging as few constructs measured by the DCaT survey reached high level of consensus within faculty members from the same department. Finally, the analysis found no relationship between psychological collective climate and the level of use of learner-centered instructional practices.

Conclusions
Results from the validation studies conducted on the DCaT survey that most elements that define a climate (e.g., policies, practices, expectations) are lacking when it comes to teaching. These findings could explain the challenges experienced in this study in measuring departmental collective climate. Without these climate elements, faculty members are left to work autonomously with little expectations for growth in their instructional practices. Establishing policies, practices, and expectations with respect to teaching is thus an essential step toward instructional change at a departmental level.
Strawberry agro-industrial by-products as a source of bioactive compounds: effect of cultivar on the phenolic profile and the antioxidant capacity
Authors: Villamil-Galindo Esteban , Van de Velde Franco , Piagentini Andrea M. 
Published: July 2021

AbstractThe post-harvest processing of strawberries generates considerable amounts of by-products that consist of the inedible parts of the fruit (sepal, calyx, stem, and non-marketable portion of the fruit), which is an environmental problem for local producers and industries. This study aimed to revalue these kinds of tissues through identifying and quantifying the genotype influence on the total phenolic content, phenolic profile, and the antioxidant activity of the by-products from three strawberry cultivars: ‘Festival’ (FE), ‘San Andreas ‘ (SA), and ‘Camino Real’ (CR). The total phenolic content was determined by the Folin–Ciocalteu method, in-vitro antioxidant activity by the DPPH* radical scavenging method and the phenolic profile by PAD–HPLC. The different genotypes showed significant differences (p < 0.05) in total phenolic content (TPC), FE being the one with the highest TPC (14.97 g of gallic acid equivalents < GAE > /Kg of by-product < R >), followed by SA and CR cultivars. The antioxidant capacity of the SA and FE tissues were similar (p > 0.05) and higher (15.1–16.3 mmol Trolox equivalents < TE > /Kg R) than CR. Eight main phenolic compounds were identified and quantified on the three cultivars. Agrimoniin was the principal polyphenol (0.38–1.56 g/Kg R), and the cultivar FE had the highest concentration. This compound showed the highest correlation coefficient with the antioxidant capacity (R2 0.87; p < 0.001). This study highlighted the impact of the multi-cultivar systems in strawberry production on the bioactive potential and the diversity of secondary metabolites obtained from strawberry agro-industrial by-products at a low cost.
Association between milk and yogurt intake and mortality: a community-based cohort study (Yamagata study)
Authors: Nakanishi Akiko , Homma Erika , Osaki Tsukasa , Sho Ri , Souri Masayoshi , Sato Hidenori , Watanabe Masafumi , Ishizawa Kenichi , Ueno Yoshiyuki , Kayama Takamasa , Konta Tsuneo 
Published: July 2021

Abstract
Background
Dairy products are known as health-promoting foods. This study prospectively examined the association between milk and yogurt intake and mortality in a community-based population.

Methods
The study population comprised of 14,264 subjects aged 40–74 years who participated in an annual health checkup. The frequency of yogurt and milk intake was categorized as none (< 1/month), low (< 1/week), moderate (1–6/week), and high (> 1/day) intake. The association between yogurt and milk intake and total, cardiovascular, and cancer-related mortalities was determined using the Cox proportional hazards model.

Results
During the follow-up period, there were 265 total deaths, 40 cardiovascular deaths and 90 cancer-related deaths. Kaplan–Meier analysis showed that the total mortality in high/moderate/low yogurt intake and moderate/low milk intake groups was lower than that in none group (log-rank, P < 0.01). In the multivariate Cox proportional hazard analysis adjusted for possible confounders, the hazard ratio (HR) for total mortality significantly decreased in high/moderate yogurt intake group (HR: 0.62, 95% confidence interval [CI]: 0.42–0.91 for high intake, HR: 0.70, 95%CI: 0.49–0.99 for moderate intake) and moderate milk intake group (HR: 0.67, 95% CI: 0.46–0.97) compared with the none yogurt and milk intake groups. A similar association was observed for cancer-related mortality, but not for cardiovascular mortality.

Conclusions
Our study showed that yogurt and milk intake was independently associated with a decrease in total and cancer-related mortalities in the Japanese population.
Successive perioperative management of laparoscopic liver resection in the reverse Trendelenburg position for a patient with Fontan physiology: a case report
Authors: Saito Kazutomo , Toyama Hiroaki , Saito Moeka , Yamauchi Masanori 
Published: July 2021

Abstract
Background
Laparoscopic surgery for a patient with Fontan physiology is challenging because pneumoperitoneum and positive pressure ventilation could decrease venous return and the accumulated partial pressure of arterial carbon dioxide (PaCO2) could increase pulmonary vascular resistance, which might lead to disruption of the hemodynamics.

Case presentation
A 25-year-old man with Fontan physiology was scheduled to undergo laparoscopic liver resection for Fontan-associated liver disease (FALD) with noninvasive monitoring of cardiac output (CO) by transpulmonary thermodilution in addition to transesophageal echocardiography. The abdominal air pressure was maintained low, and we planned to switch to open abdominal surgery promptly if hemodynamic instability became apparent because of the accumulated PaCO2 or postural change. Consequently, the pneumoperitoneum had limited influence on circulatory dynamics, but central venous pressure significantly decreased with postural change to the reverse Trendelenburg position. Laparoscopic liver resection for FALD was performed successfully with no significant changes in CO and central venous saturation.

Conclusions
With strict circulation management, laparoscopic surgery for a patient with Fontan physiology can be performed safely. Comprehensive hemodynamic assessment by noninvasive transpulmonary thermodilution can provide valuable information to determine the time for shift to open abdominal surgery.
Annual dialysis data report of the 2018 JSDT Renal Data Registry: dementia, performance status, and exercise habits
Authors: Nitta Kosaku , Nakai Shigeru , Masakane Ikuto , Hanafusa Norio , Goto Shunsuke , Taniguchi Masatomo , Hasegawa Takeshi , Wada Atsushi , Hamano Takayuki , Hoshino Junichi , Joki Nobuhiko , Yamamoto Keichi , Miura Kenichiro , Abe Masanori , Nakamoto Hidetomo ,   on behalf of Japanese Society for Dialysis Therapy Renal Data Registry Committee, Maeno Kazuyuki , Kawata Tetsuya , Oyama Chikara , Seino Koji , Sato Toshinobu , Sato Shigeru , Ito Minoru , Kazama Junichiro , Ueda Atsushi , Saito Osamu , Ando Tetsuo , Ogawa Tomonari , Kumagai Hiroo , Terawaki Hiroyuki , Ando Ryoichi , Abe Masaki , Kashiwagi Tetsuya , Hamada Chieko , Shibagaki Yugo , Hirawa Nobuhito , Shimada Hisaki , Ishida Yoichi , Yokoyama Hitoshi , Miyazaki Ryoichi , Fukasawa Mizuya , Kamijyo Yuji , Matsuoka Teppei , Kato Akihiko , Mori Noriko , Ito Yasuhiko , Kasuga Hirotake , Koyabu Sukenari , Arimura Tetsuro , Hashimoto Tetsuya , Inaba Masaaki , Hayashi Terumasa , Yamakawa Tomoyuki , Nishi Shinichi , Fujimori Akira , Yoneda Tatsuo , Negi Shigeo , Nakaoka Akihisa , Ito Takafumi , Sugiyama Hitoshi , Masaki Takao , Nitta Yutaka , Okada Kazuyoshi , Yamanaka Masahito , Kan Masaharu , Ota Kazumichi , Tamura Masahito , Mitsuiki Koji , Ikeda Yuji , Nishikido Masaharu , Miyata Akira , Tomo Tadashi , Fujimoto Shoichi , Nosaki Tsuyoshi , Oshiro Yoshinori 
Published: July 2021

AbstractAccording to the annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) conducted at the end of 2018, there were a total of 339,841 patients receiving dialysis (hereinafter, dialysis patients) in Japan. The survey included questions regarding the presence/absence of dementia, the performance status (PS), and the exercise habits of individual patients. The survey revealed that 10.8% of all dialysis patients had dementia (1.8% in the age group of less than 65 years, 6.8% in the age group of 65–74 years, and 22.7% in the age group of 75 years or older). These prevalences of dementia were approximately equal to those estimated from the survey conducted in 2010. Regarding PS, the percentage of patients with lower activity levels tended to be relatively high among patients who were less than 15 years old and those who were 60 years old or older. Concerning the exercise habits of dialysis patients, the percentage of patients who were classified as “not at all or hardly” in response to the question about exercise habit was the highest (60–80%) of all the exercise habit classifications in each of the age groups analyzed.
Exploring the effect of three scaffoldings on the collaborative problem-solving processes in China’s higher education
Authors: Ouyang Fan , Chen Zixuan , Cheng Mengting , Tang Zifan , Su Chien-Yuan 
Published: July 2021

AbstractCollaborative problem-solving (CPS) engages students in solving ill-structured problems, creating group knowledge, and developing self-regulation and collaboration skills. Different scaffoldings, such as minimal-guided, task-oriented, and idea-oriented, can be used to facilitate students’ CPS activities, but their effects have not been comprehensively explored. In this research, we use minimally-guided, task-oriented, and idea-oriented scaffoldings to promote Chinese university students’ online CPS activities and use a multi-method approach to analyze the effects of three scaffolding on collaboration. The results indicate relatively complicated collaborative processes and outcomes supported by three scaffoldings. It is initially shown that the idea-centered scaffolding strengthens students’ connections between idea contribution, metacognitive regulation, and knowledge artifact behaviors, which are critical factors for improving the CPS quality. Based on the empirical research results, we conclude that future instructional design should carefully consider the educational culture, time constraint, and student regulation to better facilitate CPS practices.
The role of appendectomy in the development of Parkinson’s disease: a retrospective study in a teaching hospital in Jordan
Authors: Dahbour Said Salah , Subuh Aseel , Haddad Rama , Al-Samardali Tulay , Dahbour Aladdin 
Published: July 2021

Abstract
Background
Parkinson’s disease is a degenerative brain disease related to the accumulation of an abnormally aggregated alpha-synuclein protein. A hypothesis was presumed that this protein will be transported retrogradely from the gastrointestinal tract ultimately leading to the disease. Various epidemiologic studies have shown conflicting results. This study reports the prevalence of appendectomy in Jordanian parkinsonian patients and compares it to controls seen at one major teaching hospital in Jordan. This is a retrospective study of 266 patients compared to a control group of 500 patients randomly selected from the hospital. The prevalence of appendectomy in the 2 groups was studied.

Results
The rate of appendectomy in patients and controls was 26/266 (9.8%) and 27/500 (5.4%), respectively (relative risk 1.30, odds ratio 1.81, χ2, p = 0.026). Appendectomy in the patients was independent of gender (χ2, p = 0.297). Also, there was no difference in patients with and without appendectomy regarding their age, age at diagnosis of PD, and duration of use of levodopa (p = 0.827, 0.960, and 0.688, respectively, Student t test). The mean duration from appendectomy to the diagnosis of the disease varied widely 23 ± 18.7 years, range −12–59 years.

Conclusions
Appendectomy occurred significantly more frequent in patients with Parkinson’s disease than in control. There was no difference regarding the age of onset of disease in the patients with and without appendectomy. Though the appendix in this study seems to have a protective role against the development of the disease, the relationship is quite complex requiring prospective in-depth evaluation.
Delayed post-traumatic stress and memory inflation of life-threatening events following a natural disaster: prospective study
Authors: Heir Trond , Hussain Ajmal , Kristensen Pål , Weisæth Lars 
Published: July 2021

Background
The causes of delayed post-traumatic stress disorder (PTSD) are debated, and the validity of late-onset PTSD has been questioned.

Aims
We aimed to examine predictors of delayed PTSD in a community sample of survivors of a natural disaster.

Method
Norwegian survivors of the 2004 Indian Ocean tsunami (n = 532) responded to a questionnaire at 6 and 24 months post-disaster. The questionnaire measured PTSD symptoms, recalled exposure and immediate stress responses to the disaster, recalled perceived life threat, personality dimensions, social support and other subsequent adverse life events.

Results
When dichotomising PTSD symptom scores, 331 participants had low and 194 had high PTSD scores (early-onset PTSD) at 6 months. Of those with initially low scores, 43 (13.0%) had high symptom scores (delayed PTSD) at 24 months. The delayed PTSD group had a lower degree of initially assessed threat and witness experiences of death or suffering, lower immediate stress response and higher degree of memory inflation of perceived threat than the early-onset PTSD group. Among those with low PTSD scores at 6 months, onset of delayed PTSD was associated with neuroticism and memory inflation of life threat, but not with the degree of initially assessed disaster exposure or reports of subsequent adverse life events.

Conclusions
Lack of association between trauma exposure and delayed onset of PTSD symptoms casts doubt on whether the traumatic event is actually the primary causative factor for delayed PTSD. Our findings suggest that delayed PTSD may be a manifestation of personality factors and memory inflation of the severity of an event.
Pregnancy-specific Adaptations in Leptin and Melanocortin Neuropeptides in Early Human Gestation
Authors: Andrikopoulou Maria , Panigrahi Sunil K , Jaconia Giselle D , Gyamfi-Bannerman Cynthia , Smiley Richard M , Page-Wilson Gabrielle 
Published: July 2021

AbstractIntroductionPregnancy is characterized by increased appetitive drive beginning early in gestation, yet the central mechanisms underlying this adaptation are poorly understood in humans. To elucidate central mechanisms underlying appetite regulation in early pregnancy, we examine plasma and cerebrospinal fluid (CSF) leptin and Agouti-related peptide (AgRP) as well as CSF proopiomelanocortin (POMC) as surrogates for brain melanocortin activity.MethodsPlasma leptin, soluble leptin receptor, AgRP, and CSF leptin, POMC, and AgRP were collected from pregnant women before cerclage placement (16.6 ± 1.1 weeks; N = 24), scheduled cesarean section (39.2 ± 0.2 weeks; N = 24), and from nonpregnant controls (N = 24), matched for age and body mass index.ResultsPlasma leptin was 1.5 times higher in pregnancy vs controls (P = 0.01), but CSF leptin did not differ. CSF/plasma leptin percentage was lower in early pregnancy vs controls (0.8 ± 0.1 vs 1.7 ± 0.2; P &lt; 0.0001) and remained unchanged at term (0.9 ± 0.1), supporting a decrease in leptin transport into CSF in pregnancy. Plasma AgRP, a peripheral biomarker of the orexigenic hypothalamic neuropeptide, was higher in early pregnancy vs controls (95.0 ± 7.8 vs 67.5 ± 5.3; P = 0.005). In early gestation, CSF AgRP did not differ from controls, but CSF POMC was 25% lower (P = 0.006). In contrast, at term, CSF AgRP was 42% higher vs controls (P = 0.0001), but CSF POMC no longer differed. Overall, the CSF AgRP/POMC ratio was 1.5-fold higher in early pregnancy vs controls, reflecting a decrease in melanocortin tone favoring appetitive drive.ConclusionsPregnancy-specific adaptions in the central regulation of energy balance occur early in human gestation and are consistent with decreased leptin transport into brain and resistance to the effects of leptin on target melanocortin neuropeptides.
Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism
Authors: Liu Yu , Kuang Alan , Bain James R , Muehlbauer Michael J , Ilkayeva Olga R , Lowe Lynn P , Metzger Boyd E , Newgard Christopher B , Scholtens Denise M , Lowe William L 
Published: July 2021

Abstract

Context
Gestational diabetes is associated with a long-term risk of developing a disorder of glucose metabolism. However, neither the metabolic changes characteristic of gestational diabetes in a large, multi-ancestry cohort nor the ability of metabolic changes during pregnancy, beyond glucose levels, to identify women at high risk for progression to a disorder of glucose metabolism has been examined.

Objective
This work aims to identify circulating metabolites present at approximately 28 weeks’ gestation associated with gestational diabetes mellitus (GDM) and development of a disorder of glucose metabolism 10 to 14 years later.

Methods
Conventional clinical and targeted metabolomics analyses were performed on fasting and 1-hour serum samples following a 75-g glucose load at approximately 28 weeks’ gestation from 2290 women who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Postpartum metabolic traits included fasting and 2-hour plasma glucose following a 75-g glucose load, insulin resistance estimated by the homeostasis model assessment of insulin resistance, and disorders of glucose metabolism (prediabetes and type 2 diabetes) during the HAPO Follow-Up Study.

Results
Per-metabolite analyses identified numerous metabolites, ranging from amino acids and carbohydrates to fatty acids and lipids, before and 1-hour after a glucose load that were associated with GDM as well as development of a disorder of glucose metabolism and metabolic traits 10 to 14 years post partum. A core group of fasting and 1-hour metabolites mediated, in part, the relationship between GDM and postpartum disorders of glucose metabolism, with the fasting and 1-hour metabolites accounting for 15.7% (7.1%-30.8%) and 35.4% (14.3%-101.0%) of the total effect size, respectively. For prediction of a postpartum disorder of glucose metabolism, the addition of circulating fasting or 1-hour metabolites at approximately 28 weeks’ gestation showed little improvement in prediction performance compared to clinical factors alone.

Conclusion
The results demonstrate an association of multiple metabolites with GDM and postpartum metabolic traits and begin to define the underlying pathophysiology of the transition from GDM to a postpartum disorder of glucose metabolism.