bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-line palliative chemotherapy clinical benefit is a key determinant of survival in metastatic uterine leiomyosarcoma
Authors: ERASLAN Emrah , İLHAN Ayşegül , YILDIZ Fatih , DOĞAN Mutlu 
Published: November 2021

Aim: To evaluate whether obtaining a clinical benefit with first-line therapy in patients receiving palliative systemic therapy with a diagnosis of metastatic uterine leiomyosarcoma (ULMS) provides a survival benefit and the factors that may predict first-line therapy response.
Material and Method: This study was a retrospective observational single-center analysis conducted with patients diagnosed with metastatic ULMS. Patients who received palliative chemotherapy with an ECOG PS of 0 or 1 at the time of diagnosis of metastatic disease were included in the study. Main patient characteristics, first-line palliative treatment responses, progression-free survival, and overall survival (OS) were reviewed retrospectively. Multivariate analyses were performed to determine the independent predictive factors of first-line palliative treatment response and overall survival.
Results: Of the 36 patients whose medical records were evaluated retrospectively, 24 patients who were eligible for the study were included in the study. Gemcitabine plus docetaxel combination chemotherapy was the most commonly used treatment protocol (n=12, 50%) for first-line palliative treatment. While a complete response as a first-line treatment response could not be achieved, clinical benefit (partial remission and stable disease) and progressive disease were observed in 15 (62%) and 9 (37.5%) patients, respectively. Binary logistic regression analysis failed to detect any independent predictive factors for the clinical benefit of first-line palliative therapy. Median (OS) was 19.7 (95% CI, 4.1-35.3) months for all patients (N=24). Median OS was 25.6 (95% CI, 21.0-30.2) months and 6.9 (95% CI, 1.7-12.2) months for patients with and without the clinical benefit of first-line palliative chemotherapy (p=0.004). Cox-regression analysis revealed that increasing age at diagnosis of metastatic disease (HR=0.929, 95% CI 0.870-0.992, p=0.027), pulmonary metastasectomy (HR=0.162, 95%CI 0.031-0.863, p=0.033), and presence of first-line palliative chemotherapy clinical benefit (HR=0.195, 95% CI 0.063-0.606, p=0.005) were independent predictive factors for a better OS.
Conclusion: In metastatic ULMS, for which the survival benefit is not clear with palliative chemotherapy, prolonged survival can be obtained in patients with clinical benefit with first-line palliative chemotherapy. There is a need for new studies to determine the factors that will predict the clinical benefit of first-line palliative chemotherapy.
Evaluation nutritional status and anthropometric parameters in patients with chronic hepatitis B
Authors: YILMAZ ÖNAL Hülya 
Published: November 2021

Introduction: Hepatitis B continues to be a major health problem around the world. 257 million people are estimated to be chronically infected with hepatitis B worldwide. Chronic hepatitis B (CHB) patients are likely to develop various comorbidities, including diabetes, insulin resistance, hyperlipidemia, nonalcoholic fatty liver disease, and obesity. Proper nutrition is essential for the management of both hepatitis B and its associated comorbidities.
Material and Method: The study was completed a total of 105 patients. The universe of the study comprised of CHB patients who were admitted to the nutrition and dietetics outpatient clinic of a public hospital in Turkey between 1 October 2019 and 31 December 2019. Biochemical and ultrasound results, anthropometric measures, demographic characteristics, dietary habits, and 1-day food records were retrospectively recorded from patient files.
Results: Female patients were more likely to consume 2 main meals per day (57.8%) whereas most male subjects (75.6%) consumed 3 meals. Both female and male patients had above-normal Body Mass Index (BMI) (31.2 kg/m2 and 29.2 kg/m2, respectively), and they also had high dietary fat (%) and cholesterol consumption than recommendation. In addition, males had borderline The fasting blood glucose (FBG), total cholesterol, and triglyceride levels, and both sexes were at risk for abdominal obesity. Dietary carbohydrate, fiber, B1, B6, calcium, magnesium, and phosphorus intake were higher in males than in females.
Conclusion: This study was found on above-normal BMI values, and high dietary fat (%), and cholesterol consumption in both males and females. Moreover, males had borderline FBG, total cholesterol, and triglyceride levels, and both sexes were at risk for abdominal obesity. In the setting of CHB, it is crucial to maintain an adequate and balanced diet to control body weight, prevent nutritional disorders, protect the liver, and improve overall well-being. More comprehensive studies are needed to better understand the link between nutrition and hepatitis B.
Is macrocytic erythrocyte a new prognostic parameter in critical COVID-19 disease?
Authors: SOYLU Veysel Garani , GÜLTEN Sedat , YILMAZ Ayşe , TAŞKIN Öztürk , DEMİR Ufuk , ÇATAN İNAN Funda 
Published: November 2021

Introduction: In critical COVID- 19 patients, we aimed to examine the relationship mortality between the parameters and the macrocytic/microcytic erythrocyte population that are routinely evaluated in each patient admitted to the intensive care unit.
Material and Method: It is a retrospective cross-sectional study and was conducted in Kastamonu University, Faculty of Medicine, a tertiary hospital intensive care units located in the North of Turkey .198 nonanemic critical COVID-19 patients treated between November 2020 and February 2021 were evaluated. The patients were divided into two groups as survival and non survival. Apache II score, saps II score and routine blood examinations of the patients were evaluated.
Results: Among the groups; APACHE II score (p
Relationship between hope and fatigue levels in cancer patients
Authors: ÇELİK Melike , UĞUR Özlem , KARADAĞ Ezgi 
Published: November 2021

Aim: The aim of the present study is; to determine the relationship between fatigue and hope levels in cancer patients.
Material and Method: The study was conducted as a descriptive study. Data were collected using Socio-Demographic Data Qestionnaire, Herth Hope Index, Brief Fatigue Inventory (BFI). The questionnaires were filled outthrough face-to-face interviews.
Results: 213 cancer patients with 50.23% 21-54 years of age were taken into the study. There was no significant relationship between fatigue status of patients and sociodemographic variables. However, a significant correlation was found between the score of hope and the time after diagnosis(KW =2.608; p=0.053). In our study, the difference between mean score of hope level and gender, age,marital status, educational status and employment was not statistically significant.
Conclusions: There was a significant negative correlation between fatigue and hope total scores of the patients. This shows us that the management of fatigue during the illness and treatment positively affects the hope and patients are struggling with their disease. it is suggested that the diagnosis of fatigue and hope levels of the patients from the diagnosis and the planning of the attempts to manage them can be suggested.
The effect of body mass index on osteoporosis and fracture risk in patients with type 2 diabetes mellitus
Authors: ÖTEN Erol , ÇAPRAZ Mustafa 
Published: November 2021

Aim: Type 2 diabetes mellitus (DM), osteoporosis and obesity are increasingly common diseases due to the increase in the elderly population and the change in eating habits. However, the relationship between diabetes, obesity and osteoporosis has not been fully clarified in studies in the literature. In our study, it was investigated whether the combination of diabetes and obesity caused osteoporosis and increased fracture risk.
Material and Method: Our study was carried out with a total of 95 patients between the ages of 40 and 80, including 24 males and 71 females, who were tested due to the preliminary diagnosis of osteoporosis and diagnosed with type 2 DM in the physical medicine and rehabilitation outpatient clinic. The demographic characteristics, body mass index (BMI), bone mineral density (BMD) measurements, X-ray imaging, and fracture risk assessment scale (FRAX) calculations of patients were performed. Groups were compared in terms of BMD and FRAX according to the BMI classification.
Results: BMD and FRAX hip values were higher in the obese group according to the BMI classification compared to the pre-obese/normal group (p0.05).
Conclusion: As a result of our study, it was observed that type 2 DM and obesity were associated with increased fracture risk despite high BMD values.
The role of ECG as a mortality predictor in COVID-19 patients treated in the intensive care unit
Authors: AYDEMİR Semih , ŞAHAN Ekrem 
Published: November 2021

Background: COVID-19 infection has reached serious morbidity and mortality rates all over the world for a short time. Many studies have investigated the relationship of COVID-19 disease with mortality and morbidity. In this study, we wanted to elucidate the relationship between rhythm character (sinus rhythm vs atrial fibrillation) and QTc and frontal plane QRS-T angle, which parameters are reflecting the depolarization-repolarization kinetics, and mortality, which were not emphasized enough in previous studies.
Material and Method: 259 patients admitted to the intensive care unit due to COVID-19 infection between 01.04.2020 and 01.12.2020 was included in the study. The demographic characteristics of the patients, clinical backgrounds, laboratory values ​​at the time of admission to the intensive care unit, and 12 derivation ECG records were obtained from the patient files. Rhythm, PR distance, QRS duration and morphology, QT interval, T wave morphology, presence of atrioventricular (AV) block, QRS axis, presence of ventricular premature contraction, frontal plane QRS-T (f(QRS-T)) angle degree were determined on 12 derivation ECG records. Patient groups were classified as "deceased patient" and "survivors" and the relationship of these parameters with survival was tried to be elucidated.
Results: the frequency of atrial fibrillation was significantly higher in the "deceased patient" group. For patients in sinus rhythm, there was no difference between the two groups in terms of PR distance and 1st degree AV block. Severe AV block was not observed in either group. There was no difference between the two groups in terms of QRS morphology, T wave inversion, and ventricular premature contractions. QRS duration, corrected QTc duration, and frotal plane QRS-T angle values ​​were found to be statistically significantly higher in in the "deceased patient" group.
Conclusion: Atrial fibrillation, prolonged QTc duration and increased frontal plane QRS-T angle can be considered as mortality predictors in COVID-19 infection whose mortality rate is high all over the world.
A reliable source of information on botulinum toxin injection used in the treatment of spasticity: YouTube
Authors: ARAS Berke , KUZU Ömer 
Published: November 2021

Aim: The aim of the study is to assess the quality and reliability of YouTube videos on botulinum toxin injection for the treatment of spasticity.
Material and Method: In this cross-sectional study, a search of YouTube videos was made on 15 September 2020, using the keywords "botulinum toxin and spasticity", "botulinum toxin treatment for spasticity", “spasticity management with botulinum toxin" "treating spasticity with botox". Two experienced reviewers on botulinum toxin injection on spasticity reviewed the first 200 videos. The quality of the videos was evaluated according to the Global Quality Scale (GQS) and three groups were formed: high quality, intermediate quality and low quality. The DISCERN tool was used to evaluate the reliability of the videos.
Results: Of the 77 videos analyzed according to GQS, 36 (46.8%) were high quality, 31 (40.2%) were intermediate quality and 10 (13.0%) were low quality. Most of the videos (44.15%, n=34) uploaded by health professionals (physiatrist, orthopedist etc.) and the majority of the health professional groups had produced high quality videos (67.64%). When the parameters of the videos were compared according to quality levels, no significant differences were found in the number of view, comment, likes, dislikes, video length, days since upload (p>0.05). Significant differences were only found between the groups in respect of the DISCERN scores (p
Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy
Authors: YILMAZ Ebru , ARSLAN Memnune , AKYOL Şefika , ÖZCAN Alper , ZARARSIZ Gökmen , ABDULREZZAK Ümmühan , KONTAŞ Olgun , CANÖZ Özlem , ÜNAL Ekrem , KARAKÜKÇÜ Musa 
Published: November 2021

Aim: Hodgkin lymphoma (HL) constitutes 40% of childhood lymphomas and approximately 6% of all childhood cancers. It is tried to achieve cure with combined treatment modalities consisting of chemotherapy, radiotherapy, monoclonal antibodies, and new treatment agents such as nivolumab. Radiotherapy-related infertility, secondary cancer, thyroid dysfunction, cardiovascular diseases, pulmonary fibrosis, and local skin reactions can be seen in the pediatric age group with a long life expectancy. In this article, pediatric patients diagnosed with Hodgkin lymphoma without the use of radiotherapy in the treatment were evaluated retrospectively and the survival results were reported as a single-center experience.
Material and Method: The patients with Hodgkin Lymphoma in the Pediatrics Hematology-Oncology Center at Erciyes University between January 2010 and December 2019 were included in the study and the data of the patients were evaluated retrospectively.
Results: In 68 pediatric patients with a mean age of 10.7 (±4.6) years, the male/female ratio was 1.3. The most detected finding at the time of diagnosis was cervical lymphadenopathy (83.8%). The most common mixed cellular subtype was identified (48.5%). Stage I-II disease was observed in 38.3% of the patients, and stage III-IV disease was observed in 61.7% of the patients. The median follow-up period of the patients was 61 (range, 8.3-161.6) months. Disease-free survival and overall survival were 85.3% and 94.1%, respectively. Treatment modalities to be used in this disease group, which has a high chance of cure after cytotoxic treatment, should be selected considering treatment-related long-term complications.
Conclusion: Acceptable good results obtained without radiotherapy are satisfactory and the chance of curative success will increase with the addition of new target agents to the treatment.
Is there a relationship between the liver SUVmax values in FDG-PET/CT imaging and non-alcoholic fatty liver disease score?
Authors: ALTUNTUZCU Şadiye , GUZEL Fatih , UYAR Ali , KAPLAN İhsan , GÜZEL Yunus , TAŞDEMİR Bekir , YALÇIN Kendal 
Published: November 2021

Aim: Non-alcoholic fatty liver disease is one of the most common causes of liver disease worldwide with an estimated prevalence of 20%–30% in adult population. Following the widespread utilization of PET in the evaluation of malignant diseases, F-18 FDG have also been reported to be used in non-malignant processes. The aim of this study is to elucidate whether the FDG SUVmax values determined by PET/CT in different adipose tissue samples and the liver change according to NAFLD score. During our desktop research we did not find any published article therefore, it is the first study in this field.
Materials and Method: A total of 230 patients who applied to Dicle University Faculty of Medicine, Department of Nuclear Medicine between March and April 2020 and who have been conducted FDG PET/CT for diagnosis, staging, restaging and evaluation of response to treatment were included in the study. Patients were divided into three groups according to their NAFLD score as patients with fibrosis score 0.676 (severe fibrosis group) group-3.
Results: Liver SUVmax levels were found to be significantly higher in group-3 than group-1. No significant difference was observed between group-2 and group-3. SUVmax levels measured from supracalvicular region, posterior scapular region and mesentery region were not different from each other in all three groups. Glucose-corrected liver SUVglu levels were found to be significantly lower in group-1 than group-3 (p=0.001). In terms of liver SUVglu levels, group-1 and group-2 and group-2 and group-3 did not differ statistically from each other. Supracalvicular SUVglu, posterior scapular SUVglu and mesenteric SUVglu groups were not different from each other.
Conclusions: The most important result of this study could be elaborated with increased FDG uptake in NAFLD. Liver FDG uptake increases as the severity of NAFLD increases as demonstrated by the NAFLD score.
A utilização de pinos de fibra de vidros anatômicos como uma alternativa para a melhoria estética em tratamentos reabilitadores: revisão de literatura
Authors: Meireles Manuela Moraes , Coelho Neusimar Queiroz , Souza Gabriel Catunda de 
Published: November 2021

Introdução: Na odontologia são apresentados vários desafios e a reabilitação estética e funcional em dentes com destruição coronária é um deles. Objetivo Geral: elucidar uma revisão de literatura a respeito da reabilitação estética e funcional com pinos de fibra anatômicos. Metodologia: Para a construção desse artigo científico foi utilizada pesquisa de revisão bibliográfica descritiva da literatura. Resultados e Discussão: Quando apresentado casos onde existe uma grande perda na estrutura dentária, a utilização de pinos de fibra de vidro se apresenta como uma ótima alternativa oferecendo melhor suporte para reabilitar a unidade. Conclusão: concluímos que a técnica utilizada traz benefícios concretos tanto para o profissional quanto para o paciente. Por possuir o modulo de elasticidade próximo a dentina, possibilitando assim uma melhor distribuição de cargas, reduzindo assim o risco de fraturas.
Efetividade dos métodos de descontaminação em máscaras de tecido com luz ultravioleta e gás ozônio
Authors: Alves Débora Batista Pereira , Saraiva Lídia Lira , Souza Helen Patricia de Oliveira Duarte , Mota Mara Soares de Almeida , Santana Drielly Lima 
Published: November 2021

Com a pandemia de COVID-19, houve significativo aumento no consumo de Equipamentos de Proteção Individual, ocasionando escassez de máscaras para os profissionais da área da saúde, sendo que as máscaras em tecido desempenharam um papel fundamental na contenção da transmissão de doenças virais e bacterianas na população em geral. Diante da demanda do uso de máscaras, houve uma necessidade de pesquisar novos agentes antissépticos que pudessem proporcionar a sua reutilização. Portanto, este estudo tem como objetivo analisar a eficácia dos processos de descontaminação por ozônio e luz UV-C nas máscaras de proteção de uso não profissional em diferentes tipos de tecidos, diante da contaminação experimental por S. aureus. As máscaras foram recortadas em pequenos pedaços e contaminadas com uma solução 108 UFC/ML e comparada com a escala de Mac Farland a 0,5, descontaminadas com gás ozônio e UV-C. Os resultados mostraram eficiência em ambos os processos, ressaltando um melhor desempenho do gás ozônio mostrou em relação à UV-C. A distância da amostra em relação ao aparelho de descontaminação, o tempo de exposição e o modelo de equipamento de UV-C e ozônio podem influenciar na obtenção de resultados mais eficientes em relação a descontaminação. Mesmo com a grande variedade de produtos químicos disponíveis, busca-se reduzir os microrganismos das máscaras com UV-C ou ozônio, como forma alternativa, sem alterar estruturalmente os tecidos, e comprometer sua eficiência. O estudo pode contribuir para o lançamento de mais equipamentos que utilizem esse tipo de descontaminação, deixando esse processo mais simples e barato para a população.
УЧАСТЬ УКРАЇНСЬКОГО НАЦІОНАЛЬНОГО ПЕРСОНАЛУ В ДІЯЛЬНОСТІ МИРОТВОРЧИХ МІСІЙ МІЖНАРОДНИХ СИЛ ООН
Authors: Плазова Тетяна Іванівна , Тимощук Олександр Васильович 
Published: November 2021

З проголошенням незалежності України одним із пріоритетних напрямів зовнішньої політики нашої держави є участь у заходах міжнародної спільноти щодо підтримання миру та безпеки в світі, відвернення та врегулювання міжнарод­них конфліктів. Враховуючи, що на сучасному етапі безпека будь-якої з держав значною мірою залежить не лише від надійності її кордонів, але й від загального військово-політичного клімату, керівництво нашої країни спрямовує свою миро­творчу діяльність на співпрацю з Радою Безпеки ООН, при цьому дотримуючись загальновизнаних принципів та норм міжнародного права.
У даній статті досліджується та аналізується співпраця українського національ­ного персоналу в миротворчих місіях Міжнародних сил сприяння безпеці. Особлива увага у викладеному матеріалі приділяється законодавчій базі, що регламентує миротворчу діяльність України під егідою ООН та в рамках співпраці з НАТО. Виділено й основні завдання, які покладались на український національний персонал у міжнародних місіях.
Починаючи з липня 1992 року, вже в статусі незалежної держави Україна почала брати участь у миротворчих операціях під егідою міжнародних організацій. Такі дії нашої держави підтверджують прагнення активного підтримання всіх колективних заходів ООН щодо збереження миру та стабільності як у Європі, так і в світі загалом.
Участь України у міжнародних миротворчих операціях ООН та НАТО дає вагомі позитивні результати, а якісне і бездоганне виконання завдань з боку українських миротворців, відповідальність, мужність та високий професіоналізм сформували українським миротворцям заслужено високий авторитет.
Поряд з тим участь українських підрозділів в міжнародних місіях та операціях сприяють зміцненню іміджу нашої Держави, створенню сприятливого клімату для налагодження та активізації двостороннього співробітництва з окремими державами. Також українські військовослужбовці мають змогу отримувати унікальний професійний досвід, знайомитись з сучасними вимогами в коригу­ванні пріоритетів розвитку Збройних Сил та модернізацією озброєнь і військової техніки. Разом з тим мають нагоду вносити зміни та коригувати навчальний процес підготовки миротворчого персоналу, зокрема з використанням можли­востей військово-технічного співробітництва зі збройними силами інших держав.
Висока оцінка з боку наших міжнародних партнерів стала основним підґрун­тям для постійного запрошення України до участі у новостворюваних та вже існуючих миротворчих місіях, розширення географії залучення Збройних Сил України до миротворчої діяльності в усьому світі.
ПЕТРО ФРАНКО: ЖИТТЄПИС НА ТЛІ ЕПОХИ
Authors: Харук Андрій Іванович 
Published: November 2021

Рецензія на книгу
Тихолоз Н. (2021). Петро Франко: Формула долі (Життєпис на тлі доби). Львів: Львівський національний літературно-меморіальний музей Івана Франка, 288 с.
ПОДІЇ ДРУГОГО ЗИМОВОГО ПОХОДУ НА ТЕРИТОРІЇ ВОЛИНСЬКОЇ ГУБЕРНІЇ (1921)
Authors: Дем’янюк Олександр Йосипович 
Published: November 2021

У статті аналізуються проблеми, пов’язані із перебуванням підрозділів Дієвої Армії УНР на території Волинської губернії в жовтні-листопаді 1921 р. Звернута увага на передумови й підготовку військового походу на територію УСРР, зокрема на волинський терен. Визначено напрямки організаційної роботи щодо максималь­ного поширення повстанського руху на територію радянської України; обґрунто­вано, спираючись на зміни у суспільно-політичній ситуації в УСРР, найвдаліший момент для партизанського походу в Україну.
З’ясовано взаємини керівництва Партизансько-повстанського штабу з очіль­никами повстанських загонів на території Волинської губернії, проаналізовано причини поступового послаблення повстанського руху.
Визначено причини згортання партизанського походу в Україну, з’ясовано обставини повернення Волинської групи на територію ІІ Речі Посполитої. Названо прізвища вояків народжених на Волині, страчених більшовиками в м. Базар на Житомирщині.