bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffuse Large B Cell Lymphoma with uncommon cardiac invasion: Case Report from Palestine
Authors: Daralammouri Yunis , Hamayel Hamza , Ismail Yahya , Majadla Sajed , Odeh Razan 
Published: March 2021

Abstract
Background: Diffuse large B cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases and it is uncommon for DLBCL to present as a cardiac mass.Case Presentation: A 26-year-old female patient presented with progressive shortness of breath, facial swelling, and lower limb swelling. Echocardiography showed a large right atrial mass that was obstructing the tricuspid valve. Computed topography (CT) scan confirmed the findings and a large mediastinal mass with a filling defect in the right atrium occluding the distal Superior Vena Cava was identified. Histopathology showed DLBCL. She received 6 cycles R-CHOP chemotherapy (rituximab, cyclophosphamide, epirubicin, vincristine, and prednisone) with good response and complete resolution of the mass.Conclusions: DLBCL can present with atypical, uncommon sites as the first presentation, such as the heart. Early diagnosis and appropriate management is crucial given the poor outcome with late presentation. A high index of suspicion and the proper investigations including CT scan is recommended to allow for early intervention and favorable outcomes as what happened with the case under discussion.
Development of a Conceptual Framework of Patient-reported Outcomes in Light Chain Amyloidosis: A Qualitative Study
Authors: D'Souza Anita , Myers Judith , Cusatis Rachel , Dispenzieri Angela , Finkel Muriel , Panepinto Julie , Flynn Kathryn E 
Published: March 2021

Abstract
Background Light chain (AL) amyloidosis is a plasma cell neoplasm associated with high early mortality and severe morbidity that can cause severe disability. We explored the impact of AL amyloidosis on symptoms and well-being from the perspectives of patients and health care providers who regularly care for AL patients. We intended to develop a conceptual understanding of patient-reported outcomes in AL amyloidosis to identify the context of use and concept of interest for a clinical outcome assessments tool in this disease.Method Twenty patients and 10 professionals were interviewed. Patient interviews captured the spectrum of amyloidosis experience including time from diagnosis, type of organ involvement, and presence and type of treatment received. Interviews with professionals included physicians, advanced practice providers, registered nurse, and a patient advocate; these interviews covered similar topics. Results The impact of AL amyloidosis on patients’ life was multidimensional, with highly subjective perceptions of normality and meaning. Four major themes from patients and experts included diagnosis of AL amyloidosis, living with AL amyloidosis, symptom burden, and social roles. Barriers to patient-reported outcomes data collection in patients were additionally explored from experts. The themes provide a comprehensive understanding of the important experiences of symptom burden and its impact on daily life from AL amyloidosis patients’ and from the perspectives of professionals who care for patients with AL amyloidosis. Conclusion These findings further the conceptual understanding and identification of a preliminary model of concept of interest for development of a clinical outcome assessments tool for AL amyloidosis.
Resilient Event-based Control for Nonlinear Cyber-Physical Systems under Intermittent Deception Attacks
Authors: Yang Fan , Gu Zhou , Yan Shen 
Published: March 2021

Abstract
We address the resilient event-based control of nonlinear cyber-physical systems subject to deception attacks. In particular, an improved Takagi–Sugeno (T-S) fuzzy model is employed to solve the mismatch problem between the fuzzy system and fuzzy controllers. From the attacker's point of view, we construct a novel queuing model to depict the intermittent behaviors of deception attacks. Then, a resilient event-based communication scheme is proposed, which is dynamically switched with different attack modes. The idea is to appropriately reduce the number of triggers according to the severity level of attacks, which can further save network resources. By using piecewise Lyapunov functional methods, we find a solution to the co-design of fuzzy controllers and event-triggering parameters while the concerned system is guaranteed to be exponentially stable. Finally, we apply the proposed approaches to a mass–spring–damping system, where the effectiveness is well verified.
Energy harvested end nodes and performance improvement of LoRa networks
Authors: Gupta Gunjan , Van Zyl Robert 
Published: March 2021

Abstract
LoRa technology is derived from chirp spread spectrum (CSS) having embedded forward error correction (FEC). A wide band is used for transmissions to counter interference and to handle frequency offsets. The paper investigates low power wide area networks (LPWAN) transmissions in the uplink, where the end nodes are powered by using energy harvested from the surroundings. Long-range (LoRa) networks demonstrate their capability to support Internet of Things (IoT) applications, where the end nodes utilize the harvested energy for transmission to gateways using different spreading factor (SF) codes. The work fairly improves the throughput of the LoRa nodes while keeping the other parameters, like time duration of the energy harvesting (EH), SF, and transmit power, optimally. Initially, a mathematical expression is derived for collisions between packets of the end nodes; keeping this as an important factor, an algorithm is proposed that fairly assigns SFs to the nodes. Simulation results confirm the improvement in packet error rate and time on air when fewer LoRa nodes are used for lower SFs, as compared to higher SFs. The number of LoRa nodes that can communicate using SF = 7 is almost four times as compared to using SF = 11, while maintaining a low packet error rate. Also, for SF = 7, changing the coding rate from 1 to 4 increases time on air by around 20 ms, while time on air increases by 1,200 ms for SF = 12. The energy efficiency is also compared for different SFs and different transmission powers. A lower SF and lower transmission powers are more suitable for smaller distance and provides better energy efficiency.
Fusion Expression and Fibrinolytic Activity of rPA/SP-B
Authors: Tang Yi-Shan , Zhang Xiao-Jun , Wang Wan-Neng , Wang Ting , Cao Wu-Long , Zhang Qiu-Han , Chen Fu 
Published: March 2021

Background:
Pulmonary surfactant dysfunction is an important pathological factor in
acute respiratory distress syndrome (ARDS) and pulmonary fibrosis (PF).

Objective:
In this study, the characteristics of recombinant mature surfactant protein B (SP-B) and
reteplase (rPA) fusion protein maintaining good pulmonary surface activity and rPA fibrinolytic activity
in acute lung injury cell model were studied.

Methods:
We studied the characteristics of SP-B fusion expression, cloned rPA gene and N-terminal
rPA/C-terminal SP-B co-expression gene, and constructed them into eukaryotic expression vector
pEZ-M03 to obtain recombinant plasmids pEZ-rPA and pEZ-rPA/SP-B. The recombinant plasmids
was transfected into Chinese hamster ovary (CHO) K1 cells and the expression products were
analyzed by Western Blot. Lipopolysaccharide (LPS) was used to induce CCL149 (an alveolar
epithelial cell line) cell injury model. Fluorescence staining of rPA and rPA/SP-B was carried out
with the enhanced green fluorescent protein (eGFP) that comes with pEZ-M03; the cell Raman
spectroscopy technique was used to analyze the interaction between rPA/SP-B fusion protein and
the phospholipid structure of cell membrane in CCL149 cells. The enzyme activity of rPA in the fusion
protein was determined by fibrin-agarose plate method.

Results:
The rPA/SP-B fusion protein was successfully expressed. In the CCL149 cell model of
acute lung injury (ALI), the green fluorescence of rPA/SP-B is mainly distributed on the CCL149
cell membrane. The rPA/SP-B fusion protein can reduce the disorder of phospholipid molecules
and reduce cell membrane damage. The enzyme activity of rPA/SP-B fusion protein was 3.42, and
the fusion protein still had good enzyme activity.

Conclusion:
The recombinant eukaryotic plasmid pEZ-rPA/SP-B is constructed and can be expressed
in the eukaryotic system. Studies have shown that rPA/SP-B fusion protein maintains good
SP-B lung surface activity and rPA enzyme activity in acute lung injury cell model.
Highly Sensitive, Naked Eye, and On-Spot Detection of pH Change Using Novel Phenothiazine Based Schiff Base
Authors: Anand Vivek 
Published: March 2021

Background:
Visual pH sensors have received significant attention in the fields of environmental monitoring, analytical chemistry, food safety and biomedicine. Therefore, a single organic moiety showing both naked-eye and fluorescence sensing of pH change are rare and in higher demands.

Objective:
A novel phenothiazine based Schiff base PTz-SB was synthesized via facile organic transformations. This molecule showed promising naked-eye and on-spot pH sensing application, both using UV-visible and fluorescence techniques.

Method:
The novel phenothiazine based Schiff base was synthesized via facile organic transformation. The Schiff base was applied for both naked eye and fluorescence sensing of pH, using UV-visible and fluorescence techniques, respectively.

Result:
A Redshifts of 27 nm and 80 nm were observed in the λmax of absorption and emission
spectra, respectively, on changing the pH from 12.2 to 1. The naked-eye pH sensing
may be attributed to the change in colour from blue (higher pH) to dark green (lower pH),
under daylight conditions. Furthermore, the change in fluorescence spectra is more pronounced.
The fluorescence colour of the compound changes from dark blue to green and then
finally to orange, on changing the pH from 12.2 to 4 to 1.5, respectively. Moreover, the electrochemical
studies of the Schiff base were also procured. The bandgap obtained from the cyclic
voltammetry studies was found to be 2.04 eV, which is characteristic of green emission.

Conclusion:
The easily synthesizable novel Schiff base can be utilized for real-life, on-spot practical application of pH sensing, which does not require sophisticated analytical instruments. Moreover, the time and cost of detection of pH using this thermally robust Schiff base are also very promising.
Benzodiazepines, Amphetamines, Testosterone, and Sildenafil as New Candidate Drugs for Sexual Interest, Desire and/or Arousal Disorder
Authors: Wix Richard J. , Uribe Ezequiel 
Published: March 2021

Background:
The FDA approved drugs for female sexual interest, desidere and/or arousal disorder (FSIAD), and hypoactive sexual desire disorder (HSDD), however this have low tolerability for patients because its multiple side effects and does not show real therapeutic efficacy. Hypoactive Sexaul Desire affects from 750.000.000 to 1.400.000.000 people worldwide.

Methods:
In this paper we analyze therapeutic candidate in clinical practice as well as the methodologies clinical trials of possible therapeutic targets of different systems related to the dysfunction.

Results:
Therefore New Drugs (Benzodiazepines, Amphetamines, Testosterone, Sildenafil or New Compound) Clinical Trials to treat this disorder are necessary.
Processing, Characteristics And Applications Of Bulk Nanostructured Metals And Alloys
Authors: Srivatsan T. S. , Manigandan K. 
Published: March 2021

:
An ability to achieve useful properties in structural materials is largely dependent on their bulk microstructure. Over the years, the innate ability to achieve noticeable improvements in structural materials has relied upon processing as a viable means and/or alternative, which in turn determines the resulting microstructure and properties or behavior. Sustained research and development efforts in the domains encompassing materials science, materials engineering and manufacturing processes has made possible the arrival of a time period in which specific properties of a material can be obtained by carefully controlling the architecture of its constituents. Nanostructuring of materials to include both metals and their alloy counterparts is a key for obtaining extra ordinary properties that made them attractive for purpose of selection and use in both structural applications and functional applications. In recent years, the production of bulk nanostructured materials [BNMs] by techniques of severe plastic deformation [SPD] has attracted considerable scientific and technological interest since it offers new opportunities for the fabrication of commercial nanostructured metals and alloys that can be chosen for use in a variety of specific applications. Such nanostructured materials must essentially be not only porosity free and but also contaminant free, which makes them an ideal choice for studying, observing and documenting their characteristics spanning microstructure, properties and mechanical behavior. In this paper, we provide a compelling overview of the approaches most widely used for the purpose of achieving grain refinement using the technique of plastic deformation. An outline of the four most commonly used plastic deformation processing techniques is provided. Salient aspects specific to the technique of equal channel angular pressing [ECAP], high pressure torsion [HPT], accumulative roll bonding [ARB] of bulk nanostructured metals and surface mechanical attrition treatment [SMAT] of nanostructured layers is provided and briefly discussed. A need for the selection of certain metals and alloys for use in specific applications in the domains spanning medicine and technology are briefly discussed. The emergence and use of computational nanotechnology, which in essence synergizes the rapid developments in computational techniques and material development is presented and briefly discussed.
Virtual Health Care for Community Management of Patients With COVID-19 in Australia: Observational Cohort Study
Authors: Hutchings Owen Rhys , Dearing Cassandra , Jagers Dianna , Shaw Miranda Jane , Raffan Freya , Jones Aaron , Taggart Richard , Sinclair Tim , Anderson Teresa , Ritchie Angus Graham 
Published: March 2021

Background
Australia has successfully controlled the COVID-19 pandemic. Similar to other high-income countries, Australia has extensively used telehealth services. Virtual health care, including telemedicine in combination with remote patient monitoring, has been implemented in certain settings as part of new models of care that are aimed at managing patients with COVID-19 outside the hospital setting.

Objective
This study aimed to describe the implementation of and early experience with virtual health care for community management of patients with COVID-19.

Methods
This observational cohort study was conducted with patients with COVID-19 who availed of a large Australian metropolitan health service with an established virtual health care program capable of monitoring patients remotely. We included patients with COVID-19 who received the health service, could self-isolate safely, did not require immediate admission to an in-patient setting, had no major active comorbid illness, and could be managed at home or at other suitable sites. Skin temperature, pulse rate, and blood oxygen saturation were remotely monitored. The primary outcome measures were care escalation rates, including emergency department presentation, and hospital admission.

Results
During March 11-29, 2020, a total of 162 of 173 (93.6%) patients with COVID-19 (median age 38 years, range 11-79 years), who were diagnosed locally, were enrolled in the virtual health care program. For 62 of 162 (38.3%) patients discharged during this period, the median length of stay was 8 (range 1-17) days. The peak of 100 prevalent patients equated to approximately 25 patients per registered nurse per shift. Patients were contacted a median of 16 (range 1-30) times during this period. Video consultations (n=1902, 66.3%) comprised most of the patient contacts, and 132 (81.5%) patients were monitored remotely. Care escalation rates were low, with an ambulance attendance rate of 3% (n=5), emergency department attendance rate of 2.5% (n=4), and hospital admission rate of 1.9% (n=3). No deaths were recorded.

Conclusions
Community-based virtual health care is safe for managing most patients with COVID-19 and can be rapidly implemented in an urban Australian setting for pandemic management. Health services implementing virtual health care should anticipate challenges associated with rapid technology deployments and provide adequate support to resolve them, including strategies to support the use of health information technologies among consumers.
Temporal Dynamics of Public Emotions During the COVID-19 Pandemic at the Epicenter of the Outbreak: Sentiment Analysis of Weibo Posts From Wuhan
Authors: Yu Shaobin , Eisenman David , Han Ziqiang 
Published: March 2021

Background
The ongoing COVID-19 pandemic has led to an increase in anxiety, depression, posttraumatic stress disorder, and psychological stress experienced by the general public in various degrees worldwide. However, effective, tailored mental health services and interventions cannot be achieved until we understand the patterns of mental health issues emerging after a public health crisis, especially in the context of the rapid transmission of COVID-19. Understanding the public's emotions and needs and their distribution attributes are therefore critical for creating appropriate public policies and eventually responding to the health crisis effectively, efficiently, and equitably.

Objective
This study aims to detect the temporal patterns in emotional fluctuation, significant events during the COVID-19 pandemic that affected emotional changes and variations, and hourly variations of emotions within a single day by analyzing data from the Chinese social media platform Weibo.

Methods
Based on a longitudinal dataset of 816,556 posts published by 27,912 Weibo users in Wuhan, China, from December 31, 2019, to April 31, 2020, we processed general sentiment inclination rating and the type of sentiments of Weibo posts by using pandas and SnowNLP Python libraries. We also grouped the publication times into 5 time groups to measure changes in netizens’ sentiments during different periods in a single day.

Results
Overall, negative emotions such as surprise, fear, and anger were the most salient emotions detected on Weibo. These emotions were triggered by certain milestone events such as the confirmation of human-to-human transmission of COVID-19. Emotions varied within a day. Although all emotions were more prevalent in the afternoon and night, fear and anger were more dominant in the morning and afternoon, whereas depression was more salient during the night.

Conclusions
Various milestone events during the COVID-19 pandemic were the primary events that ignited netizens’ emotions. In addition, Weibo users’ emotions varied within a day. Our findings provide insights into providing better-tailored mental health services and interventions.
Pemanfaatan Autoclave Model 1925x Sebagai Alat Suling dengan Model Kondensor Graham dan Kondensor Allihn untuk Mendukung Praktikum Mahasiswadi Laboratorium Produksi Tanaman II Politeknik Negeri Lampung
Authors: Alqum Alqum , Tarsono Nono 
Published: March 2021

Autoclave model 1925X yang berfungsi pokok sebagai alat sterilisasi dapat dimanfaatkan fungsinya sebagai alat suling minyak atsiri dengan penggunaan bahan yang relatif sedikit dengan menambahkan model kondensor Graham dan kondensor Allihn. Perancangan alat penyulingan menggunakan autoclave sebagai alat suling dengan menambahkan kondensor Graham dan Allihn diharapkan dapat menghasilkan minyak atsiri dengan kualitas yang baik dengan rendemen yang tinggi. Modifikasi autoclave selain fungsi pokoknya sebagai alat sterilisasi juga dapat dioptimalkan fungsi lainnya yaitu sebagai alat penyulingan minyak atsiri akan mampu memberikan pelayanan yang optimal pada praktikum dan penelitian di Laboratorium. Tujuan penelitian ini adalah: (1) Mengetahui kemampuan autoclave sebagai sebagai alat suling minyak atsiri. (2) Mengetahui rendemen minyak atsiri yang dihasilkan autoclave sebagai optimalisasi fungsi alat suling dengan menggunakan jenis kondensor graham dan kondensor allihn. Metode analisis yang dipakai untuk menentukan apakah hasil perancangan alat suling autoclave model 1925X dengan menggunakan dua jenis kondensor yaitu Kondensor tipe graham dan Kondensor tipe allihn memberikann hasil rendemen minyak atsiri yaitu dengan uji deskriptik. Hasil penelitian menunjukan penggunaan autoclave dengan menggunakan kondensor tipe graham waktu keluar kondesat awal bahan sereh wangi 9,10 menit, nilam 14,61 menit, dan rimpang jahe 7,47 menit. Sedangkan rendemen bahan sereh wangi 0,44%, daun nilam 3.10% dan bahan rimpang jahe 1,42%. Sedangkan hasil penelitian dengan menggunakan kondensor Allihn waktu keluar kondesat awal bahan sereh wangi 9,10 menit, daun nilam 12,31 menit dan rimpang jahe 7,47 menit. Sedangkan rendemen bahan sereh wangi 0,24%, daun nilam 2.03% dan bahan rimpang jahe 0,10%. Rendemen minyak atsiri berbahan sereh wangi standar SNI = 1,2%, nilam standar SNI =5,5% dan bahan rimpang jahe Standar SNI=1,50%. Penelitian ini menunjukan bahwa dengan kondensor Graham menghasilkan rendemen yang lebih tinggi antara 34,5 % sampai dengan 92,9% bila dibandingkan dengan kondensor Allihn. Mampu menghasilkan minyak atsiri 63,7 % terhadap standar SNI.
Kesiapan Dinas Kesehatan Kota Surabaya Menghadapi Era Electronic Health Record (EHR)
Authors: Masyfufah Lilis , Uktutias Sendy Ayu Mitra 
Published: March 2021

Latar Belakang: E-Health merupakan inovasi Pemerintah Kota Surabaya di bidang pelayanan kesehatan yang terintegrasi antara data di puskesmas, rumah sakit, Dispendukcapil, dan Dinas Kesehatan Kota Surabaya. E-Health menjadi program layanan kesehatan mutakhir sebelum ke Electronic Health Record (EHR). Penilaian kesiapan EHR penting untuk dilakukan. Salah satu cara mengetahui kesiapan pelaksanaan adalah dengan EHR Assesment and Readiness Starter Assessment oleh Doctor’s Office Quality–Information Technology (DOQ-IT).Tujuan: Menganalisis kesiapan Dinas Kesehatan Kota Surabaya dalam menerapkan E-Health dalam rangka pelaksanaan Electronic Health Record (EHR).Metode: Penelitian deskriptif, bersifat kuantitatif. Unit analisisnya adalah satu staf bagian PIH Dinas Kesehatan Kota Surabaya dan lima staf bagian rekam medis di puskesmas perwakilan wilayah kota di Surabaya yang dipilih dengan cara acak. Teknik pengambilan data melalui wawancara. Data dianalisis berdasarkan panduan DOQ-IT. Hasil: Hasil menunjukkan sesuai indikator Penyelerasan Organisasi skor 36 dan Kapasitas Organisasi skor 68, sehingga skor total kesiapan adalah 104 (cukup kuat). Hal ini mengindikasikan kesiapan dalam menghadapi perubahan menjadi EHR dan mengindikasikan keberhasilannya. Nilai terkecil berada pada bagian koordinasi dengan seluruh pihak terkait yang masih kurang optimal. Kesimpulan: Dinas Kesehatan Kota Surabaya siap melaksanakan transformasi E-Health menjadi HER yang melibatkan semua komponen menjadi kunci keberhasilan dalam perubahan yang lebih inovatif.