bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a cardiac telehealth program to support cardiovascular diagnosis and care in a remote, resource-poor setting in Uganda
Authors: DeWyer Alyssa , Scheel Amy , Kamarembo Jenipher , Akech Rose , Asiimwe Allan , Beaton Andrea , Bobson Bua , Canales Lesley , DeStigter Kristen , Kazi Dhruv S. , Kwan Gene F. , Longenecker Chris T. , Lwabi Peter , Murali Meghna , Ndagire Emma , Namuyonga Judith , Sarnacki Rachel , Ssinabulya Isaac , Okello Emmy , Aliku Twalib , Sable Craig 
Published: August 2021

Introduction
To address workforce shortages and expand access to care, we developed a telemedicine program incorporating existing infrastructure for delivery of cardiovascular care in Gulu, Northern Uganda. Our study had three objectives: 1) assess feasibility and clinical impact 2) evaluate patient/parent satisfaction and 3) estimate costs.

Methods
All cardiology clinic visits during a two-year study period were included. All patients received an electrocardiogram and echocardiogram performed by a local nurse in Gulu which were stored and transmitted to the Uganda Heart Institute in the capital of Kampala for remote consultation by a cardiologist. Results were relayed to patients/families following cardiologist interpretation. The following telemedicine process was utilized: 1) clinical intake by nurse in Gulu; 2) ECG and echocardiography acquisition in Gulu; 3) echocardiography transmission to the Uganda Heart Institute in Kampala, Uganda; 4) remote telemedicine consultation by cardiologists in Kampala; and 5) communication of results to patients/families in Gulu. Clinical care and technical aspects were tracked. Diagnoses and recommendations were analyzed by age groups (0–5 years, 6–21 years, 22–50 years and > 50 years). A mixed methods approach involving interviews and surveys was used to assess patient satisfaction. Healthcare sector costs of telemedicine-based cardiovascular care were estimated using time-driven activity-based costing.

Results
Normal studies made up 47%, 55%, 76% and 45% of 1,324 patients in the four age groups from youngest to oldest. Valvular heart disease (predominantly rheumatic heart disease) was the most common diagnosis in the older three age groups. Medications were prescribed to 31%, 31%, 24%, and 48% of patients in the four age groups. The median time for consultation was 7 days. A thematic analysis of focus group transcripts displayed an overall acceptance and appreciation for telemedicine, citing cost- and time-saving benefits. The cost of telemedicine was $29.48/visit.

Conclusions
Our data show that transmission and interpretation of echocardiograms from a remote clinic in northern Uganda is feasible, serves a population with a high burden of heart disease, has a significant impact on patient care, is favorably received by patients, and can be delivered at low cost. Further study is needed to better assess the impact relative to existing standards of care and cost effectiveness.
Kant’s Argument for Transcendental Idealism in the Transcendental Aesthetic Revisited
Authors: Melamedoff-Vosters Damian 
Published: August 2021

AbstractThis paper provides a novel reconstruction of Kant’s argument for transcendental idealism in the Transcendental Aesthetic. This reconstruction relies on two main contentions: first, that Kant accepts the then-ubiquitous view that all cognition is either from grounds or consequences, a view he props up by drawing a distinction between logical and real grounds; second, that Kant, like most of his contemporaries, holds that our representations are the most immediate grounds of our cognition. By stressing these elements, the most threatening objection to Kant’s argument can be avoided, namely, the claim that Kant ignores the possibility that our representations of space and time are subjective in origin, but objective as regards their applicability. My reconstruction shows that this so-called neglected alternative objection is based on a conceptual confusion about the nature ofa prioricognition.
Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
Authors: Abdollahi-Karizno Mahdi , Aramjoo Hamed , Roshanravan Babak , Hosseini Mehran , Zarban Asghar , Naseri Mohsen 
Published: August 2021

Abstract

Objectives

Teucrium polium (TP) has been traditionally used for treatment of the diabetes mellitus, kidney and liver diseases, and inflammations but some studies have reported the hepatotoxicity effects of this plant. Therefore, this study was conducted to investigate the effect of TP aqueous extract on the liver of the diabetic rats.

Methods
Adult male Wistar rats were randomly divided into five groups: (Control) Normal rats that were gavaged with normal saline (1 mL), (TP100) Normal rats (Non-diabetic) that were gavaged with TP (100 mg/kg), (DM) diabetic model rats, which became diabetic by intraperitoneal injection of streptozotocin (50 mg/kg), (DTP100) diabetic rats that were gavaged with TP (100 mg/kg), and (DTP200) diabetic rats that were gavaged with TP (200 mg/kg). The effects of the aqueous extract on the blood glucose, body weight, the activities of enzyme markers of liver damage (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)) were investigated in the serum of the control and treated groups. At the end of study liver histopathology and the total antioxidant activity (TAA) test were evaluated. Finally, obtained data were analyzed by the SPSS software (version 16).

Results
Results showed that the AST and ALT levels were significantly increased in the diabetic rats (p<0.001). A comparison of 100 mg/kg and 200 mg/kg doses of TP administration in diabetic rats also showed a significant difference (p=0.01), indicating a better performance of 100 mg/kg dose. No significant difference was found between the control group and rats treated by the TP (TP100) (p=0.382). Also, triglyceride (TG) and cholesterol levels were significantly decreased in the treated groups compared to the diabetic untreated group.

Conclusions
Findings of the study revealed no hepatotoxicity, and the hepatoprotective effects of the TP were proved in the present study.
NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 infected patients: impact of melatonin as a medicinal supplement
Authors: Esmaeili Gouvarchin Ghaleh Hadi , Hosseini Abdolkarim , Aghamollaei Hossein , Fasihi-Ramandi Mahdi , Alishiri Gholamhossein , Saeedi-Boroujeni Ali , Hassanpour Kazem , Mahmoudian-Sani Mohammad-Reza , Farnoosh Gholamreza 
Published: August 2021

Abstract
The inflammasome as a multiprotein complex has a role in activating ASC and caspase-1 resulting in activating IL-1β in various infections and diseases like corona virus infection in various tissues. It was shown that these tissues are affected by COVID-19 patients. According to the current evidence, melatonin is not veridical while possessing a high safety profile, however, it possesses indirect anti-viral actions owing to its anti-oxidation, anti-inflammation, and immune improving properties. This study aims to assess the impacts of melatonin as the complementary treatments on oxidative stress agents and inflammasome activation in patients with COVID-19. Melatonin supplement (9 mg daily, orally) was provided for the patients hospitalized with a COVID-19 analysis for 14 days. For measuring IL-10, IL-1β, and TNF-α cytokines and malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) level and the expression of CASP1 and ASC genes, blood samples were gathered from the individuals at the start and termination of the therapy. Our findings indicated that melatonin is used as a complementary treatment to reduce the levels of TNF-α and IL-1β cytokines, MDA, and NO levels in COVID-19 patients and significantly increase SOD level, however, the levels of IL-10 cytokine possesses no considerable changes. The findings revealed that genes of CASP1 and ASC were dysregulated by melatonin regulating the inflammasome complex. Based on the findings of the current study, it is found that melatonin can be effective as a medicinal supplement in decreasing the inflammasome multiprotein complex and oxidative stress along with beneficial impacts on lung cytokine storm of COVID-19 patients.
A bronze hoard from Pusztasárkánytó (Mosdós-Sárkánytó puszta) and a grave assemblage from Ráksi (County Somogy) in the Piarist Museum in Budapest
Authors: Jankovits Katalin 
Published: August 2021

AbstractIn 1917, the Piarist gymnasium in Budapest (currently the Piarist Museum) acquired two important Middle Bronze Age assemblages: a hoard of the Transdanubian Encrusted Pottery culture from Pusztasárkánytó (Mosdós-Sárkánytó-puszta) (RB A2b-c) and what was probably a grave assemblage of the Koszider period from Ráksi (RB B1). Neither of these two finds has yet been fully published; J. Hampel only presented a typological selection of the finds. Archaeological scholarship lost sight of these two important assemblages after World War 2, which finally resurfaced in the exhibition organised by the Budapest History Museum in 2017. The typochronological assessment and archaeometallurgica examination of the two assemblages shed fresh light on the differences between the metalwork of the Transdanubian Encrusted Pottery culture and that of the later Koszider period.
Brick and tile kilns in Roman Pannonia – A state of research
Authors: Dobosi Linda 
Published: August 2021

AbstractDozens of Roman tile kilns have come to light in Pannonia during the last one hundred years. This paper summarizes the published tile manufacturing workshops of Pannonia in present-day Hungary, Austria, Slovenia, Croatia, and Serbia. In the first part it gives a short general overview of the structure of a workshop, discusses the problems of defining tile kilns, describes the parts of the kilns themselves and outlines the systems of classifications. The second part gives a description and catalogue of the Pannonian tile kilns.
Sacralised spaces of Mithras in Roman Dacia
Authors: Szabó Csaba 
Published: August 2021

AbstractThe Roman cult of Mithras is one of the most well documented cults in Roman Dacia, having almost 300 archaeological finds (epigraphic and figurative sources) produced in less than 170 years during the 2ndand 3rdcenturies AD. Although the rich materiality of the cult attracted European attention already in the 18thcentury, sacralised spaces of Mithras in Dacia – the mithraea of the province – were rarely analysed. This paper presents a systematic overview of the archaeologically and epigraphically attested sanctuaries. Based on the rich material of the cult it will present a new catalogue of sanctuaries of Mithras in Roman Dacia for the first time contextualising them in a new space taxonomy of Roman religious communication.
Can We Be Colleagues?
Authors: Newton Richard 
Published: August 2021

Bulletin editor Richard Newton reflects on the meaning of collegiality. Rather than a simple connection between co-workers, Newton suggests that the term is best understood as a relationship to be tended. This issue of the Bulletin reflects on the tumultuous events of 2020 and showcases the tremendous work scholars of religion have been doing in the face of the moment’s challenges. It also introduces a new advisory board while announcing the publication’s 50th anniversary, a moment that Newton hopes to celebrate— as colleagues— in future issues.
Student Engagement, Where Art Thou?
Authors: Newton Richard 
Published: August 2021

Three US professors discuss the challenge of teaching the study of religion within a higher educational setting marked by institutional and student ambivalence. Professors Matthew Baldwin (Mars Hill College), Kevin McGinnis (Stonehill College and Post University), and Leslie Dorrough Smith (Avila University) joined Richard Newton (Editor, Bulletin for the Study of Religion) for a conversation on this challenge, expressing frustrations and sharing tips. The exchange took began at the start of the Spring 2020 semester, paused during the spring recess in response to the COVID-19 pandemic, and resumed at the end of the term, offering a snapshot of the day’s challenges.
Application of Traditional Rules of Purity (Qinggui) in Contemporary Taiwanese Monasteries
Authors: Chiu Tzu-Lung 
Published: August 2021

Vinaya rules embody the ideal of how Buddhists should regulate their daily lives, and monastics are required to observe them, despite the fact that they were compiled nearly 2,500 years ago in India: a context dramatically different not only from Chinese Buddhism's present monastic conditions, but from its historical conditions. Against this backdrop, rules of purity (qinggui) were gradually formulated by Chinese masters in medieval times to supplement and adapt vinaya rules to China's cultural ethos and to specific local Chinese contexts. This study explores how the traditional qinggui are applied by the Buddhist sangha in present-day Taiwan, and contrasts modern monastics' opinions on these rules and their relation to early Buddhist vinaya, on the one hand, against classical Chan literature (such as Chanyuan qinggui) and the Buddhist canon (such as Dharmaguptakavinaya), on the other. This comparison fills a notable gap in the existing literature.
Development of the target program in the institution of general secondary education regarding the management of the process of formation of business qualities of schoolchildren
Authors: Martynets Liliia 
Published: August 2021

The most effective in the first problems of managing lighting systems in the first place is the program-centralized input. In the paper, the last steps of the school curriculum are discovered and the process of shaping the school curriculum is controlled. In general, the development of the whole program with clearly defined goals, objectives, predicted results, which is balanced with personnel and minds, obvious resources, is necessary. In the statistics, it is indicated, that the main program is intended for such goals: it is directed to the forecast of changes, updating the effectiveness of the foundation of the development and implementation of the strategy of development; it can make innovations straightforward, ensures the systematicity of the processes in the implementation of the innovation; works on the mission of the school, laying foundation for the image.
The approximate structure of the program is determined: substantiation of the problem; theoretical and methodological foundations; the purpose and objectives of the program; stages of program implementation; measures for the implementation of the program; Expected results; analysis and evaluation of the results of the innovation program.
It is established, that the development of the program has the following support: organizational support of the program – modernization of the working curriculum in accordance with the conceptual objectives of the institution; regulatory and legal support of the program – adjustment of the package of documents: development programs of the educational institution; target programs, regulations; scientific and methodological support of the program – theoretical substantiation of the subject of experimental research work; creation of a diagnostic complex for studying the personal sphere of pupils; organization of seminars, pedagogical consultations, scientific-practical conferences as effective means of directing self-educational activity of teachers on improvement of own experimental-research competence; development of special courses, focused on the formation of business qualities of pupils; material and technical support of the program – improvement of development of a methodical office; creation of a media cabinet; expansion of the school library fund, use of Internet opportunities, etc.
SOME FEATURES OF THE NOVEL FORM OF KADZUO ISHIGURO (REMAINING OF THE DAY, DON'T LET ME GO)
Authors: Silantyeva V.I. , Andreichykova O.A. 
Published: August 2021

The article examines the signs of devaluation of humanism in modern society in the context of multicultural thinking (English - Japanese). The objects of research are the novels of the Nobel (2017) and Booker (1989) Prize writer Kazuo Ishiguro - The Rest of the Day and Don't Let Me Go. In The Rest of the Day, an English writer of Japanese descent inherits and develops the tradition of the English novel, but at the same time synthesizes the peculiarities of the English mentality with the principles of honor and service in the Bushido samurai code. The subtle irony associated with the parallel "code of honor of the English butler and the Japanese samurai," according to the authors of the article, largely explains the logic of the plot of the work. The article also notes that Kazuo Ishiguro managed to reflect the deep commonality of postcolonial Englishness with the refined Japanese perception of being and duty. Although the author himself in his interviews and comments often insists that he remembers almost nothing about Japan and that he is interested in writing on universal topics, this practically always has a shocking effect in his novels. The novel Don't Let Me Go helps to understand that the peculiarity of this work is the proclamation of humanism as one of the main values of mankind at any time and under any conditions. It is noted that this idea is manifested in a conflict with the modern interpretation of the concept. Humanistic values in the novel are also revealed in the inner thoughts of the heroine, the relationship of the heroes, the actions of the heroes, and the author, even in a non-standard anti-utopian situation of ideals, ready to reflect on the moral foundations without which human life is unthinkable. In addition, the motive of man's detachment from his roots, which is very characteristic of Japanese culture, is projected on the modern European vision of the problem.
SOBRE A ARTE BRASILEIRA DA PRÉ-HISTÓRIA AOS ANOS 1960: Fabiana Werneck Barcinski (org.).
Authors: Maior Paulo Martin Souto 
Published: August 2021

Sobre a Arte Brasileira não é mais um tratado historicista dedicado aos diferentes períodos da história da arte no Brasil. Idealizado e organizado por Fabiana Barcinski, partiu de uma visão social da arte que pretendia dar um viés diferente à percepção da estética. Desde os primórdios da região como colônia portuguesa e como Nação independente depois, sem ignorar as raízes indígenas, a obra leva desde o início a uma reflexão sobre o que realmente seja a genuína arte brasileira. Para tanto, foram convidados escritores e pesquisadores de diversas instituições acadêmicas do Brasil. O resultado foi uma obra original, crítica e reflexiva sobre as múltiplas facetas da arte brasileira e sob os diferentes olhares de um grupo destacado de especialistas.
The Estimated Cost of Maintenance of Certification
Authors: LaVigne Caleb , Foulkes Guy , Kane Steve 
Published: August 2021

Background:
Maintenance of Certification (MOC) is a controversial topic in medicine for many different reasons. Studies have suggested that there may be associations between fewer negative outcomes and participation in MOC. However, MOC still remains controversial because of its cost. We sought to determine the estimated cost of MOC to the average orthopaedic surgeon, including fees and time cost, defined as the market value of the physician’s time.

Methods:
We calculated the total cost of MOC to be the sum of the fees required for applications, examinations, and other miscellaneous fees as well as the time cost to the physician and staff. Costs were calculated for the oral, written, and American Board of Orthopaedic Surgery Web-based Longitudinal Assessment (ABOS WLA) MOC pathways based on the responses of 33 orthopaedic surgeons to a survey sent to a state orthopaedic society.

Results:
We calculated the average orthopaedic surgeon’s total cost in time and fees over the decade-long period to be $71,440.61 ($7,144.06 per year) for the oral examination MOC pathway and $80,391.55 ($8,039.16 per year) for the written examination pathway. We calculated the cost of the American Board of Orthopaedic Surgery web-based examination pathway to be $69,721.04 ($6,972.10 per year).

Conclusions:
The actual cost of MOC is much higher than just the fees paid to organizations providing services. The majority of the cost comes in the form of time cost to the physician. The ABOS WLA was implemented to alleviate the anxiety of a high-stakes examination and to encourage efficient longitudinal learning. We found that the ABOS WLA pathway does save time and money when compared with the written examination pathway when review courses and study periods are taken. We believe that future policy changes should focus on decreasing physician time spent completing MOC requirements, and decreasing the cost of these requirements, while preserving the model of continued evidence-based medical education.
Gravitational Fields and Gravitational Waves
Authors: Yuan Tony 
Published: August 2021

Abstract
The relative velocity between objects with finite velocity affects the reaction between them. This effect is known as general Doppler effect. The Laser Interferometer Gravitational-Wave Observatory (LIGO) discovered gravitational waves and found their speed to be equal to the speed of light c. Gravitational waves are generated following a disturbance in the gravitational field; they affect the gravitational force on an object. Just as light waves are subject to the Doppler effect, so are gravitational waves. This article explores the following research questions concerning gravitational waves: What is the spatial distribution of gravitational waves? Can the speed of a gravitational wave represent the speed of the gravitational field (the speed of the action of the gravitational field upon the object)? What is the speed of the gravitational field? Do gravitational waves caused by the revolution of the sun affect planetary precession? Can we modify Newton’s gravitational equation through the influence of gravitational waves?
ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-driven transcription
Authors: Yuan Kai , Yu Chunhong , Lei Xiaoyun , Chen Fang , Mao Song , Lv Lu , Liu Honglu , Hu Xueying , Wang Runhan , Shen Licong , Zhang Na , Meng Yang , Shen Yunfan , Li Pishun , Huang Shi , Shao Hao , Lin Changwei , Zhang Zhuohua 
Published: August 2021

Abstract
The transposable elements (TEs) through evolutionary exaptation have become an integral part of human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While the functional impacts of TE-derived sequences on early embryogenesis are recognized, their role in malignancy has only started to emerge. Here we show that many TEs, especially the pluripotency-related endogenous retrovirus H (HERVH), are abnormally activated in colorectal cancer (CRC) samples. The transcriptional upregulation of HERVH is associated with mutations of several tumor suppressors including ARID1A. Knockout of ARID1A in CRC cells leads to increased accessibility at HERVH loci and enhanced transcription, which is dependent on ARID1B. Suppression of HERVH in CRC cells and patient-derived organoids impairs tumor growth. Mechanistically, HERVH transcripts colocalize with nuclear BRD4 foci, modulate their dynamics, and co-regulate many target genes. Altogether, we uncover a critical role for ARID1A in restraining HERVH, which can promote tumorigenesis by stimulating BRD4-dependent transcription when ARID1A is mutated.