bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propuesta sobre las necesidades de los estudiantes de las residencias estudiantiles de la Universidad de Costa Rica
Authors: Vázquez Peñaranda Rita 
Published: November 2021

El artículo trata sobre las necesidades de estudiantes de escasos recursos, expresadas por ellos mismos, que viven en la Residencia Estudiantil de la Universidad de Costa Rica. Se propone que se refuercen los conocimientos en diferentes temas como por ejemplo: drogas, enfermedades venéreas, adicción, acoso y se llegue a crear un fondo solidario entre los mismos estudiantes, una vez que sean profesionales y se hayan insertado en el mercado laboral.
Modelo de autoevaluación participativa
Authors: Olguín Leticia 
Published: November 2021

El artículo propone dos objetivos: a) Sistematizar, profundizar y validar el modelo de autoevaluación.b) Aplicar el modelo propuesto en las Especialidades de Posgrado en Derecho de la UCR.El trabajo está organizado en cinco partes: la construcción del modelo tanto en las experiencias institucionales como en las vertientes teóricas; el modelo propuesto; aplicación y evaluación de la experiencia y comentarios finales a manera de hipótesis para próximas experiencias.
COVID-19 Sürecinde İkiz Açık ve Büyüme İlişkisi: Türkiye Ekonomisi Üzerine Ampirik Bir Çalışma
Authors: KOPUK Ezgi , ÖZÇELİK Özer 
Published: November 2021

Amaç: Çalışmada, günümüz dünyasını ve yaşamın her yönünü olumsuz etkileyen COVID-19 pandemisi süreci içerisinde Türkiye ekonomisinde gözlemlenen bütçe açığı ve cari açığın ekonomik büyüme üzerindeki etkisini belirlemek amaçlanmıştır.
Tasarım/Yöntem: Bütçe açığında ve cari açıkta gözlemlenen şoklarının ekonomik büyüme üzerinde yarattığı etki, Etki-Tepki analizi ve bu etkinin yüzdesel olarak açıklaması ise Varyans Ayrıştırma analizi ile tespit edilmiştir.
Bulgular: Analiz sonuçlarına göre cari açık ve bütçe açığında görülen şokların büyüme üzerindeki etkisi pozitif olmakla beraber bu şokların etkisi çok düşük derecededir ve büyümede meydan gelen bir standart sapmalık şok en fazla bütçe açıklarından kaynaklanmıştır. Ayrıca bütçe açıklarında gözlemlenen bir şoka cari açığın verdiği tepki ilk dönemlerde pozitifken, son dönemlerde negatif olmuştur. Bu durum bütçe açıklarında gözlemlenen açıkların cari açığı tetiklediğine dayanan İkiz Açık Hipotezinin, araştırılan dönemlerde geçerli olduğunu göstermektedir.
Sınırlılıklar: Araştırma, Türkiye ekonomisi ve 2018-M1:2021-M1 zaman aralığının kullanılması ile sınırlandırılmıştır.
Özgünlük/Değer: Günümüzde hala etkisini göstermekte olan COVID-19 pandemisi sürecinde ikiz açık sorununun Türkiye ekonomisi üzerindeki etkisini belirlemek, mevcut durum için politika önerileri ve sorunların yorumlanması bakımından önemlidir. Ayrıca bu çalışma ile pandemi sürecinde Türkiye ekonomisi için yapılan araştırmalara bir katkı sağlanacağı ve fikir birliği doğrultusunda uygun politika çıkarımlarının yapılabileceği düşünülmektedir.
PENERIMAAN DIRI WARGA LANJUT USIA YANG HIDUP SENDIRI
Authors: Ajisuksmo Clara Rosa Pudjiyogyanti , Permatasari Dyah Ayu 
Published: November 2021

This study aims at obtaining description of self-acceptance of elderly who live alone by themselves, as well as factors that affect their self-acceptance. This study implemented a qualitstivee approach by interviewing four participants, two males and two femaleswith age range of 60-70 years. Self-acceptance and self-understanding were measured by aspects of feeling equal with others, having self-confidence, being responsible, outward looking and open minded, having self-determination, realizing to self limitations, and accepting the characteristics as a human. Factors that support high self-acceptance are good self-understanding, religiousity, and the attitude of their surrounding that support their presence. Low self-acceptance is caused by failure to achieve dreams and hopes, lack of social support from their children, and weak economic conditions.

Abstrak
Penelitian ini bertujuan untuk memperoleh gambaran penerimaan diri warga lanjut usia yang tinggal seorang diri, serta faktor apa saja yang mempengaruhi penerimaan diri mereka. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif yaitu wawancara kepada empat partisipan (dua berjenis kelamin laki-laki dan dua berjenis kelamin perempuan) yang tinggal seorang diri dengan rentang usia 60-70 tahun. Penerimaan dan pemahaman akan diri diungkapkan dalam aspek perasaan sederajat dengan individu lain, percaya dengan kemampuan diri, bertanggung jawab, berorientasi keluar diri, berpendirian, menyadari keterbatasan dan menerima sifat-sifat kemanusiaan dirinya. Faktor yang mendukung penerimaan diri yang tinggi adalah pemahaman diri yang baik, nilai-nilai religiusitas, dan sikap masyarakat sekitar yang mendukung kehadiran mereka. Penerimaan diri yang rendah disebabkan oleh faktor, ketidakberhasilan diri meraih impian atau harapan, kurangnya dukungan sosial dari anak, dan kondisi ekonomi yang lemah.
Outcomes of COVID-19 and risk factors in patients with cancer - a cohort study
Authors: Sengar Manju , Chinnaswamy Girish , Ranganathan Priya , Ashok Apurva , Bhosale Shilpushp , Biswas Sanjay , Chaturvedi Pankaj , Dhamne Chetan , Divatia Jigeeshu , Dsa Karishma , Jain Hasmukh , Laskar Sarbani , Moulik Nirmalya , Mummudi Naveen , Nair Sindhu , Nayak Lingaraj , Nayak Prakash , Patkar Shraddha , Pawaskar Preeti , Ramaswamy Anant , Shetty Omshree , Singh Arjun , Epari Sridhar , Thorat Jayashree , Badwe Rajendra , Pramesh C S 
Published: November 2021

Abstract
Background
Patients with cancer who develop COVID-19 are at higher risk for severe disease and death. We aimed to study the outcomes of patients with cancer who were infected with SARS CoV2, and identify risk factors for adverse outcomes after COVID-19.
Methods
We included patients with cancer, who were diagnosed with SARS CoV2 between 11th April 2020 and February 2021 at a tertiary referral cancer centre in India. We collected data on age, sex, coexisting medical conditions, type of cancer, intent of cancer management, cancer treatment details, and severity and outcome of COVID-19. The primary outcome was a composite of severe COVID (defined as grade 6 or more on the WHO ordinal scale) or death within 30 days. We performed multivariable logistic regression analysis to identify risk factors for severe COVID or death.
Results
We obtained data on 1253 patients with cancer and SARS CoV2 infection, of whom 293 (23.6%) had hematological malignancies. The severity of COVID was mild (grade 1 to 3 on WHO ordinal scale) in 1014 (81%) patients, moderate (WHO grade 4 or 5) in 167 (13%) patients and severe (WHO grade 6 or 7) in 72 (6%) patients. The primary outcome was seen in 160 patients (12.8%) and the all-cause 30-day mortality was 10.9% (138 deaths). Advanced age [adjusted OR 1.84 (0.86; 3.94)], history of smoking [aOR 1.78 (1.10; 2.91)], palliative intent of treatment [aOR 3.57 (2.48 to 5.12)] and presence of more than 2 comorbidities [aOR 1.66 (1.03 to 2.67)] were significant risk factors for severe COVID or death. Advanced age and palliative intent of treatment remained significant risk factors for 30-day mortality. Recent systemic anti-cancer therapy, sex or cancer type did not influence outcomes.
Conclusion
Most patients with cancer who developed COVID-19 in our setting had mild disease; the elderly and those treated with palliative intent were at higher risk of severe COVID-19 or death. Recent cancer therapy did not impact COVID-19 severity or outcomes suggesting that in most patients with cancer, the management of cancer should continue uninterrupted during the pandemic.
Learning the statistics of pain: computational and neural mechanisms
Authors: Mancini Flavia , Zhang Suyi , Seymour Ben 
Published: November 2021

Abstract
Pain invariably changes over time, and these temporal fluctuations are riddled with uncertainty about body safety. In theory, statistical regularities of pain through time contain useful information that can be learned, allowing the brain to generate expectations and inform behaviour. To investigate this, we exposed healthy participants to probabilistic sequences of low and high-intensity electrical stimuli to the left hand, containing sudden changes in stimulus frequencies. We demonstrate that humans can learn to extract these regularities, and explicitly predict the likelihood of forthcoming pain intensities in a manner consistent with optimal Bayesian models with dynamic update of beliefs. We studied brain activity using functional MRI whilst subjects performed the task, which allowed us to dissect the underlying neural correlates of these statistical inferences from their uncertainty and update. We found that the inferred frequency (posterior probability) of high intensity pain correlated with activity in bilateral sensorimotor cortex, secondary somatosensory cortex and right caudate. The uncertainty of statistical inferences of pain was encoded in the right superior parietal cortex. An intrinsic part of this hierarchical Bayesian model is the way that unexpected changes in frequency lead to shift beliefs and update the internal model. This is reflected by the KL divergence between consecutive posterior distributions and associated with brain responses in the premotor cortex, dorsolateral prefrontal cortex, and posterior parietal cortex. In conclusion, this study extends what is conventionally considered a sensory pain pathway dedicated to process pain intensity, to include the generation of Bayesian internal models of temporal statistics of pain intensity levels in sensorimotor regions, which are updated dynamically through the engagement of premotor, prefrontal and parietal regions.
Effect of Health Belief Model on the Participation in Fobt Crc Screening Programme: Case/Control Study
Authors: Rodríguez Martín Menéndez , García-Morales Natalia , Pillado Teresa Seoane , Ramírez Jorge Garau , Salvador Alba Traver , Jiménez Yésica Hervás , Vieito Noel Pin , Rodríguez Luis Menéndez , Cubiella Joaquín 
Published: November 2021

Abstract
BackgroundColorectal cancer is the second cancer-related cause of death in the world. Tumor stage at diagnosis is the principal prognosis factor of survival. However, the participation in the program is around 50%. The aim of the study was to identify the benefits and barriers perceived by the population when participating in a colorectal cancer screening program with faecal occult blood test.MethodsWe carried out a cases-controls study with 408 participants. We analyzed epidemiological and social variables associated with lifestyle and behavioral factors based in the Health Belief Model. We conducted a descriptive analysis, and identified variables associated to adherence by a logistic regression. ResultsVariables independently associated with the participation in a colorectal cancer screening program were age (OR 1.06; 95% CI: 1.01-1.11), having a stable partner (OR 1.96; 95% CI: 1.20-3.18), the level of education (OR 1.59; 95% CI:1.02-2.47) and two of the barriers to participate in the faecal occult blood test screening: “not to know how to do it” (OR=0.46; 95% CI: 0.23-0.93) and “to take the test is currently not a major problem” (OR=0.43; 95% CI: 0.24-0.78).Conclusion The existing barriers for screening with faecal occult blood test are the best factor predicting. This is relevant when designing the intervention programs, as they should focus on reducing perceived barriers to increase the participation in colorectal cancer screening, thereby reducing colorectal cancer mortality.
Effects of Tumor-Rib Distance and Dose-Dependent Rib Volume on Radiation-Induced Rib Fractures in Patients with Breast Cancer
Authors: Lee Sang Mi , Lee Jeong Won , Kim Woo Chul , Min Chul Kee , Kim Eun Seog , Jo In Young 
Published: November 2021

Abstract
Background
Radiation-induced rib fracture (RIRF) is one of the adverse effects of conventional radiotherapy on breast cancer. This study aimed to investigate the effects of tumor-rib distance and dose-dependent rib volume on RIRFs in patients with breast cancer.
Methods
We retrospectively included 510 women with breast cancer who underwent curative surgical resection with subsequent adjuvant radiotherapy and were followed up using bone scintigraphy. Adjuvant radiotherapy was administered to the whole breast at 50 Gy in 25 fractions for 5 weeks and to the tumor bed at 10–16 Gy in 5–8 fractions. The tumor-rib distance was measured using preoperative computed tomography (CT) images. Postoperative chest wall thickness and dose-dependent rib volumes, which are absolute rib volumes receiving >20 Gy (V20), 30 Gy (V30), 40 Gy (V40), 45 Gy (V45), and 50 Gy (V50), were measured from the stimulation CT images for radiation treatment planning. RIRFs were identified using follow-up bone scintigraphy images. We assessed the relationship of RIRF with tumor-rib distance, postoperative chest wall thickness, and dose-dependent rib volumes.
Results
The median follow-up duration was 58.8 months, and 92 patients (18.0%) experienced RIRF. Univariate analysis revealed that osteoporosis, surgery type, radiation field, tumor-rib distance, postoperative chest wall thickness, V20, V30, V40, V45, and V50 were risk factors for RIRF (p<0.05). Patients with high values of tumor-rib distance and postoperative chest wall thickness had significantly lower risks of RIRF than those with low values. Patients with high values of V20, V30, V40, V45, and V50 had significantly higher risks of RIRF than those with low values. In multivariate analysis, tumor-rib distance and all five dose-dependent rib volumes, as well as osteoporosis and radiation field, were independent risk factors for RIRF (p<0.05).
Conclusions
Tumor-rib distance and dose-dependent rib volume were independent risk factors for RIRF in patients with breast cancer. Restriction of the absolute rib volumes in the radiation field could be effective in reducing the risk of RIRF.
A preliminary study for an intraoperative 3D bioprinting treatment of severe burn injuries.
Authors: Albouy Marion , Desanlis Adeline , Brosset Sophie , Auxenfans Celine , Courtial Edwin-Joffrey , Eli Kyle , Cambron Scott , Palmer Justin , Vidal Luciano , Thépot Amélie , Santos Morgan Dos , Christophe Marquette 
Published: November 2021

Abstract
Background: Intraoperative three-dimensional (3D) fabrication of living tissues could be the next biomedical revolution in patient treatment. Approach: We developed a surgery-ready robotic 3D bioprinter and demonstrated that a bioprinting procedure using medical grade hydrogel could be performed using a 6-axis robotic arm in vivo for treating burn injuries.Results: We conducted a pilot swine animal study on a deep third-degree severe burn model. We observed that the use of cell-laden bioink as treatment substantially affects skin regeneration, producing in situ fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF), necessary for tissue regeneration and re-epidermalization of the wound. Innovation and Conclusion: We described an animal study of intraoperative 3D bioprinting living tissue. This emerging technology brings the first proof of in vivo skin printing feasibility using a surgery-ready robotic arm-based bioprinter. Our positive outcome in skin regeneration, joined with this procedure's feasibility, allow us to envision the possibility of using this innovative approach in a human clinical trial in the near future.
What Facets of Picky Eating Relate To Eating Concerns in Undergraduate Students?: The Moderating Effects of Inflexible Eating and Mental Health Concerns
Authors: Barnhart Wesley R. , Dial Lauren A. , Jordan Amy K. , Studer-Perez Emma I. , Kalantzis Maria A. , Musher-Eizenman Dara R. 
Published: November 2021

Abstract
Purpose: Picky eating (PE) can occur in adulthood and is associated with mental health concerns. PE is often conceptualized as distinct from disordered eating, but recent research maps positive relationships between these maladaptive eating phenotypes. Relatedly, recent research suggests PE is more strongly related to eating concerns, a facet of disordered eating, via inflexible eating and mental health concerns, but precisely what PE facets explain these relations remain unknown.Methods: A large, undergraduate sample (N=509) completed an online survey assessing PE facets (Adult Picky Eating Questionnaire; meal presentation, food variety, meal disengagement, and taste aversion), disordered eating (Eating Disorder Examination Questionnaire), specifically eating concerns, mental health concerns (Depression, Anxiety and Stress Scale - 21 Items), and inflexible eating (Inflexible Eating Questionnaire).Results: Positive relationships emerged between PE facets, eating concerns, inflexible eating, and mental health concerns. Meal disengagement was more strongly associated with eating concerns when inflexible eating was higher, whereas food variety and meal presentation were more strongly associated with eating concerns when mental health concerns was higher. Inflexible eating and mental health concerns did not significantly interact with taste aversion to explain variance in eating concerns.Conclusions: Considering PE multidimensionally may yield important insights beyond the broader construct. Mental health concerns and inflexible eating may be treatment and research targets in addressing the overlap between PE facets such as meal presentation, meal disengagement, and food variety and eating concerns. Level of Evidence: Level V, cross-sectional descriptive study.
Smad Interacting Protein-1 is Essential for Oligodendrocyte Differentiation
Authors: Chen Ziwei , Wang Yuanmei , Fan Xiaobin , Huang Jufang , Fan Chunling 
Published: November 2021

Abstract
Precursor/stem cell substitutive therapy to promote remyelination is an ideal strategy for central nervous system demyelinating diseases such as spinal cord injury (SCI). However, the microenvironment of the injured area is not conducive to the survival, differentiation, and functions of the transplanted cells. Identifying and regulating the key inhibitory factors might be an important target for the treatment of demyelinating diseases. Smad interacting protein-1 (Sip1) is a transcription factor that binds to phosphorylated R-Smad in the nucleus, which promotes remyelination by inducing the differentiation of oligodendrocytes. In this study, we show that the expression of Sip1 is up-regulated and peaks by 1 day and then returns to normal levels 7 days after SCI. Most Sip1 positive cells were oligodendrocytes. In vitro, Sip1 was weakly expressed in the cytoplasm of oligodendrocyte progenitor cells (OPCs), significantly up-regulated in immature oligodendrocytes, and showed significant nuclear transposition. In contrast, Sip1 expression levels in mature oligodendrocytes decreased to levels similar to those in OPCs. The RNA interference of Sip1 in OPCs reduced the level of myelin basic protein (a mature oligodendrocyte marker protein, MBP) and pERK1/2 (a key molecule of the ERK/MAPK pathway) in oligodendrocytes. These findings suggest that Sip1 is essential for oligodendrocyte differentiation and might affect the ERK/MAPK signal pathway. The results provide a theoretical basis for the treatment of demyelinating lesions such as spinal cord injury by regulating Sip1 expression in oligodendrocytes.
Depression Scores and Quality of Life of Vertiginous Patients, Suffering from Different Vestibular Disorders
Authors: Molnár András , Maihoub Stefani , Mavrogeni Panayiota , Tamás László , Szirmai Ágnes 
Published: November 2021

Abstract
Background:Vertigo complaints are strongly associated with deterioration of patients’ quality of life (QoL). Vertigo and dizziness can result in depression and anxiety; therefore, the diagnosis and management of these concomitant psychiatric disorders can improve the patients’ quality of life. The aim of the present study was to contrast the QoL impairment and depression scores of patients suffering from different vestibular disorders. Methods:301 patients were examined due to vertiginous complaints at the Neurotologic Tertiary Rereferral Centre of the Department of Otolaryngology and Head and Neck Surgery of Semmelweis University. These patients completed the Hungarian version of the Dizziness Handicap Inventory (DHI), the Beck Depression Inventory, and the Symptom-Checklist-90-Revised (SCL-90-R) questionnaires. Results:According to neurotologic examination, the distribution of the different diagnoses was as follows: Ménière’s disease (n= 101), central vestibular disorders (n= 67), benign paroxysmal positional vertigo (n= 47), vestibular neuritis (n= 39), other unilateral peripheral vestibulopathy (n= 18), Persistent Postural-Perceptual Dizziness (n= 16), vestibular migraine (n= 8), and vestibular Schwannoma (n= 5). The results of the DHI questionnaire have indicated worsened QoL in 86.4%, out of which 33.6% was defined as severe. The Beck scale has shown depressive symptoms in 42.3% of the cases, with severe symptoms in 6.3%. Significantly higher total DHI and Beck scale results were observed in patients with central vestibular disorders, vestibular migraine, Persistent Postural-Perceptual Dizziness and unilateral peripheral vestibulopathy, contrasted to the results of the other four diagnosis groups. The onset of the symptoms did not significantly affect the severity of QoL worsening and depression symptoms.Conclusion:In this study, the QoL of vertiginous patients was worse in general, with the occurrence of depression symptoms. Difference was observed in case of the values of patients with different vestibular disorders, indicating the importance of different factors, e.g., central vestibular compensation, behavioural strategies and psychological factors.
Synthesis of typical sulfonamide antibiotics with [14C]- and [13C]-labelling on phenyl ring for environmental studies
Authors: Wu Xuan , Yao Yao , Wang Lianhong , Zhou Dashun , Sun Feifei , Chen Jianqiu , Corvini Philippe Francois-Xavier , Ji Rong 
Published: November 2021

Abstract
Background

As a kind of widely used antibiotics, sulfonamide antibiotics (SAs) has become ubiquitous environmental contaminants that caused public concerns. The behavior of SAs in complex environmental system need to be elucidated, which is hampered by unavailability or high cost of isotope-labelled SAs.
Results

Using commercially available uniformly [l4C]- and [l3C]-labelled aniline as starting material, we synthesized [phenyl-ring-14C]- and [phenyl-ring-l3C]-labelled sulfamethoxazole (SMX), sulfamonomethoxine (SMM), and sulfadiazine (SDZ) using four-step (via condensation of labelled N-acetylsulfanilyl chloride and aminoheterocycles) or five-step (via condensation of labelled N-acetylsulfonamide and chloroheterocycles) reactions in good yields (5.0−22.5% and 28.1−54.1% for [14C]- and [13C]-labelled SAs, respectively) and high purities (> 98.0%).
Conclusion

The synthesis of [l4C]-labelled SAs could be completed on milligram-level, being feasible for preparation of labelled SAs with high specific radioactivity. This study provides efficient and maneuverable methods to obtain a variety of [14C]- or [13C]-labelled SAs for studies on their environmental behavior, such as fate, transformation, and bioaccumulation.