bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Connecting Bridges on Vortex-induced Vibration of Skyscrapers
Authors: Köhserli Mehmet , Várkonyi Péter L. 
Published: December 2021

The shapes of slender skyscrapers are unfavourable for carrying horizontal loads. In this paper, we investigate the possibility of improving their structural behaviour by adding urban-scale networks of structural connections among the buildings. We focus on vibrations of skyscrapers in response to wind-induced vortex shedding. We develop a conceptual model of those structural networks composed of springs, dampers and point masses. The proposed model enables rapid numerical simulations involving large networks, which is not possible in the case of more detailed engineering models. The effect of connections, dilatation gaps, and network size are investigated for random collections of high-rise buildings, and triangular networks of horizontal bar connections among them. It is found that connections efficiently reduce vibrations in the network, especially for large network size. This study aims to be a first step towards uncovering the benefits of a novel form of urban development. A karcsú felhőkarcolók alakja kedvezőtlen a rájuk ható vízszintes terhek viselése szempontjából. Munkánkban a szerkezeti viselkedés javítási lehetőségeit vizsgáljuk az épületeket összekötő szerkezeti kapcsolatok városi léptékű hálózata segítségével. Vizsgálatunk középpontjában a szél által kiváltott örvényleválás okozta szerkezeti rezgések állnak. A rendszert rugókból, csillapítóelemekből és tömegpontokból álló koncepcionális modell segítségével írjuk le. Ez a megközelítésmód lehetővé teszi nagy hálózatok gyors numerikus szimulációját, amely részletesebb mérnöki modellek esetében nem lehetséges. Véletlenszerűen generált épületcsoportok, és vízszintes rúdszerű kapcsolatokból kialakított háromszögelt hálózatok esetén vizsgáljuk a kapcsolatoknak, a bennük kialakított dilatációs hézagoknak és a hálózat méretének a hatását. Eredményeink azt mutatják, hogy a kapcsolatok jelentősen csökkentik a hálózat rezgéseit, különösen nagy hálózati méret esetén. A tanulmány célja, hogy kezdeti lépéseket tegyünk egy újszerű városfejlesztési modell előnyeinek feltárására.
A comparative surface analysis of explanted hip prostheses: stainless steel and Co-Cr alloy versus titanium alloy
Authors: Bermúdez-Castañeda Ángela , Esguerra-Arce Johanna , Esguerra-Arce Adriana , Vargas-Pabón Sofia Valentina , Ortiz-Martínez Juan Guillermo , Blanco-Estupiñán David Leonardo , Castaño-González Juan Guillermo , Mischler Stefano 
Published: December 2021

The introduction of modular design in total hip arthroplasty has enabled the use of different materials in one single configuration and the adjustment of the prosthesis to the patient’s body, and facilitated medical revisions. However, modularity leads to the presence of new interfaces created between pieces in contact, raising the issue of degradation. Tribocorrosion phenomena have been identified as the main degradation mechanism due to the mechanical, chemical, and electrochemical conditions acting on the materials. In addition, conditions inside the human body are unclear, regarding electrochemical settings and the interaction between the electrochemical and mechanical action. This work is focused on the degradation of monopolar hip joint implants made from biomedical alloys such as stainless steel, Ti, and CoCr alloys. Three cases are presented and analyzed in terms of the degradation level along the trunnion length. Surface analysis done on a titanium trunnion showed a significant ploughing on the distal part, compared to what was found for stainless Steel and cobalt-chromium alloys, which can produce a stuck in this area. Meanwhile, in the proximal part, wear debris is found, which suggests more movement in the internal part. Although few debris particles were identified in CoCr trunnion, a large amount of material inside the contact was observed. This could be related to the ploughing generated in the distal thread pattern, which allowed the material to come inside and outside the contact.
Cattle Grazing and Forest Devastation in Brazil
Authors: Medrado Joana 
Published: December 2021

This article examines the history and present-day dynamics of deforestation and cattle grazing in Brazil’s Amazon. It discusses the long-standing strategic alliance between agribusiness and the Brazilian state, as well as the role of livestock grazing in Brazil’s developmental ideology of the frontier. It shows how the livestock industry is enlaced with soy production in the deterritorialization and deforestation of the Amazon, as well as the legalized theft of indigenous lands. It places these
Brazilian dynamics into larger international context and analyses the class structure and state capture of Brazil’s agro-industrial sector.
Study of histopathological spectrum of ovarian lesions
Authors: Patel Keval A , Parmar Riddhi A , Patel Jaimin M , Sharma Bhawana S , Patel Bimal , Patel Navin 
Published: December 2021

Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable. In order to have a better understanding of frequency and histomorphological patterns of different ovarian lesions study was encountered in our tertiary care hospital.To study the histopathology of ovarian non-neoplastic and neoplastic lesions and to study the distribution of ovarian lesions with respect to various parameters like age, bilaterality, gross and microscopic features.This is a prospective study of 125 ovarian specimens received in department of pathology, G.K. General Hospital, Bhuj during August 1, 2018 to July 31, 2020. Total 125 cases of ovarian specimens were studied, amongst them 58 were non-neoplastic and remaining 67 were neoplastic. The most common non-neoplastic lesion seen was follicular cysts 12 cases (21%), followed by endometriosis 9 cases (16%). Among 67 neoplastic ovarian lesions 58(87%) cases were benign, 3(4%) cases were borderline and 6 (9%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesions were serous cystadenoma 24 cases (36%) followed by 13 cases (20%) of mature cystic teratoma. In malignant cases, maximum was of high-grade serous cystadenocarcinoma.Ovarian epithelial tumours are the most common type, while serous cystadenocarcinoma was the most common malignancy. Histological examination is gold standard and in certain difficult cases require immunohistochemistry.Ovary is an important reproductive organ with involvement in production of progeny.Ovarian pathology ranges from innocuous non-neoplastic lesions to malignant neoplastic entities. Ovarian neoplasms have become increasingly important not only because of the wide range of neoplasms, but also because they have gradually increased the mortality rate. The incidence, clinical appearance and the behaviour of the different types of ovarian tumour is extremely variable.
Zur Aussprache niederländischsprachiger Familiennamen aus dem Bereich des Sports durch polnische Muttersprachler – theoretische Grundlagen und exemplarische Analysen
Authors: Tworek Artur 
Published: December 2021

The aim of the following article is to analyze the pronunciation of Dutch surnames by Polish native speakers. The research material consists of journalistic statements from the communicative-semantic area of sport that are present in public audiovisual mass media. The selected material guarantees the high frequency of its production and the associated perception within the real acts of communication. In particular, the examination includes Dutch sounds which either do not exist in Polish or occur in a different graphical-distributional context. The exemplary research results (the mode of phonetic integration of foreign speech sounds) represent mechanisms that are interpreted in relation to typical communication models. The study also analyzes the potential placement of such phonetic forms in the target language, i.e. Polish.
De (mythe van de) luie Javaan. De koloniale standpunten van een vader en zijn zoon (over Sytze en Philippus Pieter Roorda van Eysinga)
Authors: Honings Rick 
Published: December 2021

In 1818, Sytze Roorda van Eysinga travelled to the Dutch East Indies together with his wife and three daughters. After his arrival, he was appointed as church minister in Batavia by the governor-general. A short time later, his son Philippus Pieter Roorda van Eysinga, who stayed in the Netherlands after his parents’ departure, followed his family to the colony. In the following years, father and son both travelled through the Indonesian archipelago. After his return to the Netherlands, Philippus would become a prominent linguist in Javanese and Malay. After the death of Sytze in 1829, Philippus published his fathers’ and his own travel experiences in four volumes under the title: Verschillende reizen en lotgevallen van S. Roorda van Eysinga (1830–1832). Their texts provide a fascinating insight into colonial ideas in the first decades of the 19th century. How did Sytze and Philippus represent the indigenous people of the colony and what similarities and differences can be found in their accounts?
The Existence Of The University Of Muhammadiyah Malang Library During The Covid-19 Pandemic
Authors: Puspitasari Dian , Zawawi Moh 
Published: December 2021

The Covid-19 virus has caused a pandemic in Indonesia in 2020. This virus is classified as an infectious disease that results in policies such as physical distancing, social restrictions both small and large scale and lockdown. The impact of the Covid-19 virus has been felt in various sectors, including the college sector under which there are library units. The college library as an information center, of course, will provide information services to meet the needs of academic community. UPT UMM Library is one of the universities that still exists despite the Covid-19 pandemic. The purpose in this writing analyzes how the existence of UPT UMM Library during the pandemic. The study method used by descriptive study type with qualitative approach and data analysis technique using descriptive qualitative analysis model owned by John W Cresswell. Innovations made by UPT UMM Library during the Covid-19 pandemic to remain in existence, namely to innovate library services including creating myUMM Library, changing the concept of information literacy services into digital (online) and more actively providing library services through social media. In addition, librarians during the Covid-19 pandemic can still exist and develop by attending various online seminars and actively writing various scientific works to gain several champions.Keywords: Covid-19, Existence, Higher Education Library Services, Librarian, UMM LibraryABSTRAKVirus Covid-19 telah mengakibatkan terjadinya pandemi di Indonesia pada tahun 2020. Virus ini tergolong dalam penyakit menular yang mengakibatkan adanya kebijakan seperti physical distancing, pembatasan sosial baik berskala kecil ataupun besar dan lockdown. Dampak dari virus Covid-19 telah dirasakan berbagai sektor salah satunya sektor perguruan tinggi yang di bawah naungannya terdapat unit perpustakaan. Perpustakaan perguruan tinggi sebagai pusat informasi, tentunya akan memberikan layanan informasi guna memenuhi kebutuhan civitas akademika. UPT Perpustakaan UMM merupakan salah satu perpustakaan perguruan tinggi yang tetap eksis meskipun adanya pandemi Covid-19. Tujuan dalam penulisan ini menganalisis seberapa eksistensi UPT Perpustakaan UMM pada masa pandemi. Metode kajian yang digunakan adalah kajian deskriptif dengan pendekatan kualitatif dan teknik analisis data menggunakan model analisis kualitatif deskriptif milik John W Cresswell. Inovasiinovasi yang dilakukan UPT Perpustakaan UMM pada masa pandemi Covid-19 agar tetap eksis yaitu melakukan inovasi layanan perpustakaan diantaranya menciptakan myUMM Library, merubah konsep layanan literasi informasi ke dalam bentuk digital (online) serta lebih aktif memberikan layanan perpustakaan melalui media sosial. Selain itu, pustakawan di masa pandemi Covid-19 tetap bisa eksis dan berkembang dengan mengikuti berbagai seminar online dan aktif menulis berbagai karya ilmiah hingga mendapatkan beberapa juara.
Remote Mentoring Optimizes Virtual Collection of Patient-Reported Data: A Prospective Cohort Study with Adaptive Design Conducted in COVID-19 Era.
Authors: Kazazian Karineh , Bogach Jessica , Johnston Wendy , Ng Deanna , Swallow Carol J. 
Published: December 2021

Abstract
Prior to the COVID-19 pandemic, patients attending ambulatory clinics at cancer centers in Ontario completed the Edmonton Symptom Assessment Scale (ESAS) at each visit. At our center, completion was via touch pad, with assistance by clinic volunteers. As of March 2020, clinic appointments were conducted virtually when possible and touch pads removed. We anticipated a negative impact on the collection of patient-reported outcomes (PROs), and the recognition of severe symptoms.Methods: We performed a prospective cross-sectional cohort study to test the feasibility of remote ESAS completion by patients with appointments at a weekly surgical oncology clinic. Patients in the initial study cohort were asked to complete and return the ESAS virtually(V). Given low completion rates, the ensuing cohort was asked to complete a hard-copy(HC) ESAS. For the final cohort, we used an adaptive approach, providing remote, personal mentorship by a member of the care team to support virtual electronic ESAS completion (virtual-mentored(VM) cohort). Results: Between May-July 2020, a total of 174 patient encounters were included in the study. For the V cohort, 20/46 patients (44%) successfully completed and returned the electronic ESAS, compared to 49/50 (98%) for the HC cohort. For the VM cohort (n=78), the completion rate was 74%. Questionnaire completion was not predicted by age, sex or tumor site, although patients who completed the ESAS were more likely to be in active management rather than surveillance(p=0.04). Of all completed forms, 42% revealed a depression score ≥2, and 27% an anxiety score ≥4.Conclusions: We identified significant barriers to the virtual completion of ESAS forms, with a lack of predictive variables. The severe degree of psychological distress reported by ~50% of respondents demonstrates the need for ongoing regular collection/review of these data. Innovative solutions are required to overcome barriers to virtual collection of PROs.
The liver and muscle secreted Hfe2-protein maintains blood brain barrier integrity
Authors: Wang Xue Fan , Vigouroux Robin , Baglaenko Yuriy , Nikolakopoulou Angeliki , Ringuette Dene , Rus Horea , DiStefano Peter , Dufour Suzie , Shabanzadeh Alireza , Syonov Michal , Lee Seunggi , Mueller Bernhard , Charish Jason , Harada Hidekiyo , Fish Jason , Wither Joan , Wälchli Thomas , Cloutier Jean-Francois , Zlokovic Berislav , Carlen Peter , Monnier Philippe 
Published: December 2021

Abstract
Liver failure causes blood-brain-barrier (BBB) breakdown leading to central nervous system damage, however the mechanisms whereby the liver influences BBB-integrity remain elusive. One possibility is that the liver secretes an as-yet to be identified molecule(s) that circulate in the serum to directly promote BBB integrity. We developed light-sheet imaging for three-dimensional study of BBB function. We show that liver- or muscle-specific knockout of Hfe2 induces BBB breakdown, leading to accumulation of toxic-blood-derived fibrinogen in the brain, lower cortical neuron numbers, and behavioral deficits. In healthy animals, soluble Hfe2 competes with its homologue RGMa for binding to Neogenin, thereby blocking RGMa-induced downregulation of PDGF-B and Claudin-5 in endothelial cells and the ensuing BBB disruption. Hfe2 administration in an animal model of multiple sclerosis prevented paralysis and immune cell infiltration by inhibiting RGMa-mediated BBB alteration. This study has implications for the pathogenesis and potential treatment of diseases associated with BBB dysfunction such as multiple sclerosis.
Dynamic Response Prediction of Bi-State Emission of Quantum Dot Lasers Based on Machine Learning
Authors: Santos Wild Freitas da Silva , Filho Eduardo Furtado Simas , Thé George André Pereira 
Published: December 2021

Abstract
Dual-state emission is a common and important phenomenon which takes place in semiconductor Quantum Dot Lasers at different temperature and operating conditions usually investigated from microscopic carrier interaction modeling or even rate-equations based approaches. In this study, we revisit the topic, but the investigation is here performed from a system identification perspective; we built black-box models based on artificial neural networks approach, using the Multilayer Perceptron, the Extreme Learning Machine and a hybrid Echo State Network - Extreme Learning Machine. As a case study, we focused on switch-on transient and its prediction. The study revealed the model was able to separate and to predict, from the solely total power, without using any QDL design parameters, the optical power around the ground state and first excited state lasing lines of InAs/InGaAs quantum dot laser. The error performance was low as a RMSE of 2.81 μW and MAPE of 0.50% with processing time (training and testing time) of 15.27 s, enabling the alternative model to be used in optical filtering instrumentation as low-resolution and low-cost filters for applications in which it is not economically viable to use a spectrum analyzer, which can be replaced by a simple optical power meter.
Cryo-EM Structure-guided Selection of Computed Ligand Poses to Enhance Potency in MTA-synergic Inhibition of Human Protein Arginine Methyltransferase 5
Authors: Yadav Gaya , Zhou Wei , Yang Xiaozhi , Li Chenglong , Jiang Qiu-Xing 
Published: December 2021

Abstract
The potential of using cryo-electron microscopic (cryo-EM) structures of 2.5-4.0 Å resolutions for structure-based drug design was proposed recently, but is yet to be materialized. Here we show that a 3.1 Å cryo-EM structure of protein arginine methyltransferase 5 (PRMT5) is sufficient to guide the selection of computed poses of a bound inhibitor and its redesign for much higher potency. PRMT5 is an oncogenic target and its multiple inhibitors are in clinical trials for various cancer types. However, all these PRMT5 inhibitors manifest negative cooperativity with a metabolic co-factor analog --- 2-methylthioadenosine (MTA), which is accumulated substantially in cancer patients carrying defective MTA phosphorylase (MTAP). To achieve MTA-synergetic inhibition, we obtained a pharmacophore from virtual screen and synthesized a specific inhibitor (11-2F). Cryo-EM structures of the 11-2F/MTA-bound human PRMT5: MEP50 complex and its apo form together showed that the inhibitor binding in the catalytic pocket causes a shift of the cofactor-binding site by 1.5 – 2.0 Å, disfavoring cofactor-binding and resulting in positive cooperativity between 11-2F and MTA. Coarse-grained and full-atomistic MD simulations of the ligands in their binding pockets were performed to compare computed poses of 11-2F and its redesigned analogs. Three new analogs were predicted to have much better potency. One of them, after synthesis, was ~4 fold more efficient in PRMT5 inhibition in the presence of MTA than 11-2F itself. Computational analysis also suggests strong subtype specificity of 11-2F among PRMTs. These data demonstrate the feasibility of using cryo-EM structures of near-atomic resolutions and computational analysis of ligand poses for better small molecule therapeutics.
Hospitalized Children with Critical SARS-CoV-2 Infection Cared for in a Limited Resource Setting: Multicenter Cohort Study
Authors: de Fariasa Emmerson C.F. , Piva Jefferson P. , Junior Manoel J.C. Pavão , Sales Susan C.D. , Nascimento Luciana M.P. , Pavão Dalila C.A. , Santos Valeria T.S. dos , Pinheiroa Andressa H.O. , Alves Marília C.B. , Mello Mary L.F. M.F. , Carvalho Patricia B. , Justino Maria C.A. , Clemente Gleice , Terreri Maria Teresa 
Published: December 2021

Abstract
Background: Some children can develop severe forms of SARS-CoV-2 infection either acutely or later, as represented by multisystemic inflammatory syndrome in children (MIS- C). To identify the risk factors for worse outcomes in hospitalized children and adolescents with severe acute SARS-CoV-2 infection and MIS-C. Methods: This multicenter cohort study included all children and adolescents with confirmed or suspected critical SARS-CoV-2 infection admitted to the PICU between April 2020 and September 2021. The exclusion criteria were incomplete vaccinal status, immunocompromised status, and end-of-life decision. The main variables analyzed were epidemiological, clinical, and laboratory data, and ventilator settings at admission and after 72 h. The patients were divided into three groups (G): confirmed coronavirus disease (COVID-19) with MIS-C criteria (G1), confirmed COVID-19 without MIS-C criteria (G2), and MIS-C criteria without confirmed COVID-19. Results: The median age of the patients was 28 months in G1, with comorbidities in 40 patients (72.7%) (p < 0.0001). The duration of exposure (median 23 days; p = 0.004) and fever were longer in G1 (12 days; p = 0.001). Moreover, invasive mechanical ventilation (IMV) was required in 44 patients (80%, p < 0.0001), and cardiogenic shock occurred in 26 patients (54.2%, p < 0.0001) in G1. Subnutrition was most frequent in G1 in 55 cases (57.3%; p = 0.01). Under nutrition (< 2 SD for weight), longer exposure time (odds ratio [OR]: 2.11; 95% confidence interval [CI]: 1.37–3.25; p = 0.001), IMV time (OR: 2.6; 95% CI: 1.15–5.85; p = 0.03), and length of hospital stay (OR: 10.94; 95% CI: 1.93–63.1; p = 0.007) were associated with critical MIS-C in G1. Conclusions: In the Brazilian Amazon area, specifically in the Pará state, we identified a cluster of more severe forms of pediatric acute or late SARS-CoV-2 infection.
Dispersal and fire limit Arctic shrub expansion
Authors: Liu Yanlan , Riley William , Keenan Trevor , Mekonnen Zelalem , Holm Jennifer , Zhu Qing , Torn Margaret 
Published: December 2021

Abstract
Arctic shrub expansion has been widely reported in recent decades, with large impacts on carbon budgets, albedo, and warming rates in high latitudes. However, predicting shrub expansion across regions remains challenging because the underlying controls remain unclear. Observational studies and models typically use relationships between observed shrub presence and current environmental suitability (climate and topography) to predict shrub expansion, but such approaches omit potentially important biotic-abiotic interactions and non-stationary relationships. Here, we use long-term high-resolution satellite imagery across Alaska and western Canada to show that observed shrub expansion has not been controlled by environmental suitability during 1984-2014, but rather can only be explained by accounting for seed dispersal and fire. These findings provide the impetus for better observations of recruitment and for incorporating currently underrepresented processes of seed dispersal and fire in land models to project shrub expansion and future climate feedbacks. Integrating these dynamic processes with projected fire extent and climate, we estimate that shrubs will expand into 25% of the non-shrub tundra by 2100, in contrast to 39% predicted using a relationship with increasing suitability alone. Thus, using environmental suitability alone likely overestimates and misrepresents the spatial pattern of shrub expansion and its associated carbon sink.