bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Clinical Outcomes of Robotic Intracorporeal Single-Stapled Anastomosis (RiSSA) in Total Mesorectal Excision for Rectal Cancer
Authors: Huang Shih-Feng , Tan Yung-Lin , Hsu Chao-Wen , Tseng Chin-Lun , Tseng Hsin-Ping , Miskovic Danilo , Wu Chih-Chien 
Published: December 2024

Abstract

Robotic intracorporeal single-stapled anastomosis (RiSSA) is an innovative technique in robotic low anterior resection with total mesorectal excision (LAR-TME), though its outcomes remain underreported, particularly among Asian rectal cancer patients. This study retrospectively evaluated early clinical outcomes of RiSSA in robotic LAR-TME performed at a tertiary medical center in Kaohsiung, Taiwan. A total of 22 rectal cancer patients undergoing robotic LAR-TME with RiSSA between May 2023 and September 2024 were reviewed. Demographic and tumor-related factors such as age, gender, BMI, tumor size, and location were analyzed, along with key surgical and postoperative outcomes including blood loss, operative time, complications, mortality, length of hospital stay, ICU admissions, readmissions, and reoperations. The median patient age was 60.4 years. 72.7% of the patients were male. Median BMI and tumor size were 23.0 kg/m² and 3.6 cm, respectively. 68.2% of the tumors were in the mid or lower rectum. The median console time was 186.5 minutes. The median intraoperative estimated blood loss was 40 mL. No mortality or anastomotic leakage occurred. The median hospital stay was 7 days, with only three minor complications (Clavien-Dindo I-II) reported, including wound infections and chyle leakage. No unplanned ICU admissions, readmissions, or reoperations occurred. These findings suggest that RiSSA during robotic LAR-TME is a safe and feasible alternative to conventional double-stapled anastomosis methods, demonstrating favorable short-term outcomes with minimal complications. Further large-scale studies are warranted to validate its long-term safety and clinical effectiveness.
Vonoprazan-containing dual and triple therapies are noninferior to bismuth-quadruple therapy for Helicobacter pylori eradication: A prospective, real-world study
Authors: Qi Ya-Bin , Li Xiao-Ting , Shao Qiao-Qiao , Xu Lu , Zhang Wen-Jing , Song Shuai-Bo , Yan Qin-Nan , Shi Shi-Yu , Hu Ruo-Bing , Mekky Amr , Zhang Chen , Ma Jing , Xiao Wei , Li Kuan , Liu Ting-Ting , Fang Xin-Hui , Zhang Li-Da , Yang Guo-Hong , Ding Song-Ze 
Published: December 2024

Abstract

Background
Vonoprazan and amoxicillin dual therapy (Vo-Amx) has shown promising results on H. pylori eradication. However, its efficacy needs to be verified in this both H. pylori and gastric cancer prevalent area, and it is also unknown if the modified Vo-Amx plus bismuth (Vo-Amx-Bis) regimen might increase its efficacy. We aimed to investigate the efficacy and safety of Vo-Amx and Vo-Amx-Bis regimens, and if the Vo-Amx-Bis regimen might be superior to Vo-Amx and bismuth-containing quadruple therapy (BQT) therapy for H. pylori eradication, as well as factors that affect the curing rate.
Methods
A total of 342 treatment-naïve H. pylori-infected patients were screened and 210 were enrolled and randomized into Vo-Amx, Vo-Amx-Bis, and BQT groups for treatment. H. pylori infection status was determined by 13C-urea breath test. The eradication rate and incidence of adverse events were assessed, and factors that might affect the curing rate were also analyzed.
Results
In per-protocol (PP) analysis, H. pylori eradication rates in Vo-Amx, Vo-Amx-Bis, and BQT groups were 95.1%, 92.3%, and 90.4%, respectively (p > 0.05). In intention-to-treat (ITT) analysis, eradication rates in Vo-Amx, Vo-Amx-Bis, and BQT groups were 91.8%, 90%, and 88.2%, respectively (p > 0.05). The eradication efficacy of Vo-Amx and Vo-Amx-Bis groups was non-inferior to that of BQT group, and the incidence of side effects (including nausea, vomiting, anorexia, abdominal pain, diarrhea, palpitation, dizziness, and debilitation) was lower than that of BQT group (6.1% and 5.1%, vs 45.8%, respectively, p < 0.001). Successful eradication was associated with lower body surface area (BSA) in BQT group (p < 0.05), but not in Vo-Amx and Vo-Amx-Bis groups. Gender, cigarette smoking, alcohol drinking, side effects, education level, body mass index (BMI), infection status of family members, and the frequency of dining out did not affect the curing rate in all three groups (p > 0.05).
Conclusion
Efficacy of the two vonoprazan-containing regimens was comparable and non-inferior to the bismuth-based quadruple therapy in this region, and could serve as the first-line regimen for H. pylori eradication, and reduced use of one antibiotic per each patient treatment in real-world clinical application. (ChiCTR2400087205).
Different clinical manifestations of Dengue fever
Authors: Abdel-Monem shimaa Arafat , Abdelmaksoud Aida Ahmed , Fahim Dalia Fahim Mohammed , Ali Shymaa Sayed Salem , Ghweil Ali A , Nafady Asmaa , Bazeed Ahmed Shamardan , Sayed Mennatallah Ali Abdelrhman , Bazeed Shamardan Ezzeldin Sayed 
Published: December 2024

Abstract

Background: Dengue fever is a widespread mosquito borne infection transmitted by Aedesa egypti arthropod.
Aim of study to assess gastrointestinal, cochleovestibular, and respiratory symptoms in patients with Dengue fever and to analyze the variables that affect it.
Methods: This was across-sectional survey study with 100 patient's dengue fever. All patients were assessed for different clinical presentations of dengue fever. All investigations were repeated for all patients after one and three months.
Results: The mean age was 37.97±16.1 years. There was clinical improvement apart from watery diarrhea with significant statistics after three months during follow up (P value 0.003). Four (4%) patients presented with hearing loss and tinnitus after the onset of fever. Two of them (2%) had bilateral mild sensorineural hearing loss, two (2%) had unilateral sudden profound sensorineural hearing loss. Four patients (4%) complaining of tinnitus only, PTA revealed mild to moderate high frequency sensorineural hearing loss during examination. On one and three months follow up, most of those patients show no improvement. As regards respiratory manifestations, twenty-eight (28%) patients were presented with respiratory symptoms. The most common symptom was dyspnea seen in 26 (26%) patients, cough in 22 (22%) patients, and Hemoptysis in 1 (1%) patient.
Conclusions: Patients with serologic confirmed dengue infection may present typical GI manifestations such as nausea, diarrhea, and abdominal pain. While A typical GI manifestations were splenomegaly, and ascites. Also, concomitant cochleovestibular and respiratory symptoms that were manifested for the first time. Their outcome was heterogonous.
Influence of Limestone-Treated Construction Waste Aggregates on Mortar Properties: Optimization Using Response Surface Methodology
Authors: Golla Uday Kiran , Ganesan Nakkeran , Roy Dipankar , Mamillapalli Indumathi , Bhukya Govardhan Naik 
Published: December 2024

Abstract

Multiple sectors, including agriculture and construction, have produced large amounts of waste in recent years, leading to significant environmental problems. The construction sector is currently faced with the severe difficulties of decreasing natural resources and a growing dependence on waste management, highlighting the need for quick action for an approach to recycling and the introduction of alternative materials. The study concentrates on recycling waste materials and developing innovative construction products. This includes replacing 20% of cement with limestone powder and rice husk, replacing 50% of fine aggregates with construction and demolition waste, and incorporating 1% coconut fiber. The evaluation of these materials involved conducting tests to assess compressive strength, split tensile strength, and flexural strength using cube, cylinder, and beam samples parallel to water absorption and non-distractive tests. The methods in machine learning, including Response Surface Methodology, were utilized for prediction, showing enhanced hardened properties. This study suggests that incorporating waste materials into construction practices can protect natural resources and provide sustainable options for the future.
Categorizing Crowd Emotions based on Cross Division Expressions and Anomalies
Authors: K Manojkumar , L Suji Helen 
Published: December 2024

Abstract

The crowd emotion sensing is a critical element in surveillance and management of the crowd in different environments. With exploding populations, and developing nations, the crowd in urban cities mandate state of art surveillance methodologies involving continuous monitoring and reporting of criminal activities. The research article presents a novel technique to compute the spatial and temporal features obtained from the crowd environments and combine the novelty of neural networks for detecting the emotions of crowds with better accuracy and swiftness. The features are obtained from the continuous feed of surveillance videos typically categorized into the common features of human beings namely anger, sadness, disgust, surprise, fear, happiness and obviously neutrality. Such features are extracted after careful background separation which are typically difficult in crowded environments, using techniques namely SIFT, and FAST termed to be the visual descriptors. Once the features are extracted, spatial and temporal features are classified into individual and combined features as defined in the cross-division environment in order to portray the crowd dynamics and characteristics. Cross division environment computes the necessary features for identifying the anomalies in the crowded situations in a neural network, after a series of operations such as dimensionality reduction, and principal component analysis. From the semantic information, crowd behaviours are detected based on interactive features in a dynamic environment and the proposed technique has demonstrated effective results in terms of 98.9% accuracy in detecting especially violence in crowd datasets collected from UMN.
Metode Drill dalam Pembelajaran Retorika Mahasiswa Program Studi Tadris Bahasa Indonesia IAIN Madura
Authors: Jinan Roihal 
Published: December 2024

One method that lecturers can apply to improve students' communication skills is the drill method. The drill method is a practical exercise that must be done repeatedly by students to gain knowledge and public speaking skills so that a person's speech becomes less rigid, fluent and structured. This research is included in qualitative descriptive research with research subjects, namely Indonesian Tadris students. To collect data, researchers used observation and documentation guidelines. The process of implementing the drill method in the rhetorical abilities of students in the Indonesian Tadris Study Program at IAIN Madura has gone well. This method is applied in stages 1) goal setting, 2) explanation of instructions, 3) precision, 4) practice, 5) evaluation, and 6) repetition. The application of the training method to Indonesian Language Tadris students at IAIN Madura is very good, not only improving speaking skills, but also increasing students' confidence in speaking in public in various communication contexts.
Sustainable biodiesel synthesis from oleic acid: kinetic study with carbonized bambara nutshell catalyst
Authors: Kefas Haruna Mavakumba , Abubakar Abdulhalim Musa , Aliyu Muhammad Jimada , Bulus Raymond , Stojchevski Martin , Soomro Suhail Ahmed 
Published: December 2024

Mineral content in bambara nutshell (BNS) can act as active sites for catalysis, while the protein content can be carbonized to produce support structures for the catalyst. BNS char based solid acid catalyst is produced in this study for biodiesel (FAME) production, using oleic acid esterified with methanol. The objective of the study is to determine the order of reaction ran at 50-65 for 180 min utilizing the integral kinetic rate expression. It also involves analyzing the rate constants obtained, so as to use it to estimate the activation energy () and pre-exponential factors () necessary to describe the mechanism of the reaction. Findings show that, the presence of -OH functional group in BNS makes it a good candidate for biodiesel production. Faster reaction and conversion to FAME product ( 52%) occurred at 65. The first-order model almost describes the experimental data at 60 and R2 = 0.9850, only that it has an intercept, which is not typical of the model; although not a sufficient reason to discard it. In this study, the best model fitted is second-order at the lowest temperature analyzed (i.e., 50 with rate constant, = 2 L/mol.min L/mol.min), due to faster reaction rate described by its higher value of 6.973 L/mol.min. However, the first-order rate’s low energy requirement ( 51.63 kJ/mol), was the reason for its sluggishness compared to second-order 65.17 kJ/mol; which explains the reason why the choice of the best model could go both ways, if energy efficiency is considered. Despite the performance of the oleic acid, which is favorably described by the first- and second-order rate, its conversion to biodiesel is moderately significant.
Protective Role of Vitamin C and Silymarin Against Olanzapine-Induced Hepatotoxicity in Albino Rats: A Histopathological and Biochemical Study
Authors: Kaleem Shahid , Bhat Ghulam Mohammad , Wani Lateef Ahmad , Zargar Rehana , Kaleem Zahid 
Published: December 2024

Background:
Olanzapine is an atypical antipsychotic drug for treating bipolar disorders and Schizophrenia. Regardless of being used as a common antipsychotic
drug, there are reports of hepatic abnormalities caused by using Olanzapine. Silymarin and Vitamin C have been shown to have hepatoprotective
effects.

Objective:
The purpose of the present was to study the hepatotoxic effects of Olanzapine and the hepatoprotective role of Silymarin and Vitamin C on the
Liver of Albino rats.

Methods:
The study was conducted on 24 albino rats. The animals were randomly divided into four groups of six rats each: Group A consisted of six rats and
served as the control group; Group B consisted of six rats who received orally 4mg/kg of Olanzapine daily; Group C consisted of six rats who
received 4mg/kg of Olanzapine plus 200mg/kg of Silymarin daily and Group D consisted of six rats which received orally 4mg/kg of Olanzapine
plus 15mg/kg of Vitamin C daily. The animals were sacrificed in two sittings at four and eight weeks, and tissues were processed by routine
histopathological technique. The liver enzymes (AST, ALP, ALT) were calculated and analyzed statistically using one-way ANOVA.

Results:
It was found that the liver of rats treated with Olanzapine showed sinusoidal dilatation, sinusoidal congestion, central venous congestion, central
venous dilatation, cellular infiltration, and portal triaditis. The liver enzymes (AST, ALP, ALT) were markedly raised in the drug-treated rats,
showing Olanzapine as a hepatotoxic agent. On the other hand, Silymarin and Vitamin C) both proved to show an excellent hepatoprotective effect.

Conclusion:
Olanzapine administration causes histopathological and biochemical abnormalities in the liver. Vitamin C and Silymarin are both potent
hepatoprotective agents against Olanzapine-induced hepatic toxicity.
Purification, Characterization, and Antimicrobial Activity Against
Candida parapsilosis and Staphylococcus aureus of a Highly Stable Type-1
Cystatin from Terminalia catappa L. Seeds
Authors: Moura Amanda M.A. , Oliveira José Tadeu A. , Sousa Daniele O.B. , Dias Lucas P. , Araújo Nadine M.S. , de O. Rocha Raquel , Aguiar Tawanny K.B. , Neto João M.M. , Silva Viviane O. , Feitosa Ricardo M. , Chaves Queilane L.S.G. , Ramos Márcio V. , Freitas Cleverson D.T. 
Published: December 2024

Introduction:
Clinic infections caused by various microorganisms are a public health
concern. The rise of new strains resistant to traditional antibiotics has exacerbated the problem.
Thus, the search for new antimicrobial molecules remains highly relevant.

Methods:
The current study purified, characterized, and assessed the antimicrobial activity of a papain
inhibitor from Terminalia catappa L. seeds.

Results:
The inhibitor was purified by heating the crude extract at 80°C for 30 min, followed by
ion exchange chromatography on a DEAE cellulose column. The purification index was 9-fold,
yielding 2.3%. SDS-PAGE and size exclusion chromatography revealed that the protease inhibitor
(TcPI) is a 15.9 kDa monomeric protein. The inhibition kinetics showed that TcPI is a competitive
inhibitor specific to papain (Ki = 1.02 x 10-4 M). TcPI remained active even after heating at 100oC
for 120 min and at pH conditions varying from 2.0 to 10.0. Even after 60 min, TcPI was resistant
to papain proteolysis. TcPI exhibited antimicrobial activity against Candida parapsilosis and Staphylococcus
aureus.

Conclusion:
Here, we show that TcPI is a highly stable type-1 cystatin with the potential to combat
infections caused by C. parapsilosis and S. aureus. Additional investigations into TcPI's structural
aspects and mechanism of action, as well as safety assessments, are essential prerequisites
for its potential application as a novel therapeutic intervention.
Preparation and Evaluation of Tetrandrine Nanocrystals to Improve Bioavailability
Authors: Xue Fei , Yang Lan , Ma Shuai , Chang Jin Hua , Liu Pei , Liu Xi Gang , Wang Ru Xing 
Published: December 2024

Background:
Tetrandrine (TET) has multiple pharmacological activities, but its water
solubility is poor, which is the main reason for its low bioavailability.

Objectives:
The purpose of this study was to prepare TET nanocrystals (TET-NCs) using a grinding
method to enhance the dissolution rate and ultimately improve the bioavailability of TET.

Methods:
TET-NCs were synthesized via media milling, employing Poloxam 407 (P407) as surface
stabilizer and mannitol as a cryoprotectant during freeze-drying. The crystal structure, particle diameter,
and zeta potential were characterized using differential scanning calorimetry (DSC), Fouriertransform
infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray diffraction
(XRD). The in vitro release behavior and pharmacokinetics of TET-NCs were assessed. The cytotoxicity
of TET and TET-NCS on RAW264.7 cells was determined by the CCK-8 method.

Results:
The particle size of TET-NCs was 360.0±7.03 nm, PDI was 0.26±0.03, and zeta potential
was 6.64±0.22 mV. The cumulative dissolution within 60 minutes was 96.40±2.31%. The pharmacokinetic
study showed that AUC0-72 h and Cmax of TET-NCs were significantly enhanced by 3.07
and 2.57 times, respectively, compared with TET (p<0.01). TET-NCs significantly increased the cell
inhibition on RAW264.7 cells compared to the TET (P<0.01).

Conclusion:
The preparation of TET-NCs enhanced dissolution rate and bioavailability significantly,
and it also improved the inhibition effect of RAW264.7 cells.
Factors Affecting Knowledge Management for the Elderly Health System: Case Studies from Sub-district Municipalities and Administrative Organizations in Thailand
Authors: Limmethee Apichat , Dhirathiti Nopraenue Sajjarax 
Published: December 2024

Background
Thailand is in the process of transitioning into an aging society, which will significantly impact the health system for the elderly. Local administrative organizations play a crucial role in providing public health services for the elderly, as they are the closest level of government management to the people. Employing knowledge management in the government sector has enabled the provision of various forms of public services.

Objective
The study aims to explore the factors and conditions related to knowledge management for elderly health within local administrative organizations in Thailand.

Methods
This qualitative research methodology uses a case study design, with the unit of analysis being the Sub-district municipality and Sub-district Administrative Organization. The research tools are interviews and focus groups. The data are analyzed by content and thematic analysis.

Results
The findings indicate that the main factors related to knowledge management for the elderly health system include organizational culture, leadership and vision, supporting networks within the local area, and government agencies. Supporting factors include local culture and community philosophers. Policy suggestions, including local administrative organizations, must act as a coordinator and supporters of the health system for the elderly, emphasizing the creation of a network both inside and outside the area, drawing people of various age groups to join the health network in the local area, and preparing the population to be healthy before they enter the elderly stage.

Conclusion
The study recommends that local administrative organizations prioritize promoting factors within their area to support knowledge management for the elderly health system, which significantly impacts operational success. Furthermore, they should collaborate with other government agencies to address diverse health issues for the elderly.
Low dietary diversity is associated with stunting among children aged 8-23 months in stunting locus area, Yogyakarta, Indonesia
Authors: Lestari Putri , Irawati Winda , Hositanisita Hastrin , Paratmanitya Yhona , Nurhayati Eka , Yi Lee Yi , Ariftiyana Siska , Rahayu Herwinda Kusuma 
Published: December 2024

<p align="center"><strong> </strong></p><p><strong><em>Background: </em></strong><em>Stunting is impaired growth and development that children experience, caused by poor nutrition during 1000 days of life</em><em>. Dietary diversity is one of the core indicators for assessing diet quality and adequacy of complementary feeding.</em></p><p><strong><em>Objectives: </em></strong><em>This study aimed to analyzed the relationship between dietary </em><em>d</em><em>iversity and </em><em>st</em><em>unting among children aged 8-23 months in Pajangan District, Bantul Regency, Yogyakarta.</em></p><p><strong><em>Methods: </em></strong><em>This was a quantitative observational cross-sectional study. Purposive random sampling was used to recruit a total of 167 children aged 8-23 months with their mothers/ caregivers as respondents. Individual dietary diversity was assessed by minimum dietary diversity with the consumption of 5 or more food groups of the total 7 food groups. Logistic regression, chi-square test, and descriptive statistics were used for data analysis.</em></p><p><strong><em>Results: </em></strong><em>Results showed that prevalence of stunting was 32.3% and 54.5% of children did not meet the minimum dietary diversity. There was a significant relationship between dietary diversity on complementary feeding and stunting (p=0.005, OR=2.558; 95%CI= 1.422-4.142). Furthermore, other factors related to dietary diversity were child’s age, mother's employment status</em><em>,</em><em> father's education, father’s employment, and family income.</em><em></em></p><p><strong><em>Conclusions: </em></strong><em>There was a relationship between dietary diversity and stunting among children aged 8-23 months in </em><em>Pajangan District, Bantul Regency</em><em>, Yogyakarta. Strategy to improve dietary diversity on complementary feeding are needed to prevent child malnutrition.</em></p><p><em> </em></p><p><strong>KEYWORDS</strong><strong><em>: </em></strong><em><em>complementary feeding; </em></em><em>d</em><em>ietary diversity</em><em>; stunting</em></p>