bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thiol-Ene Click Synthesis of Adsorption Functionalized Poly(Ionic Liquid)s: Influence of the Mole Fraction of Pendant Enes
Authors: Li Wen , Wang Aili , Ye Tingting , Li Siqiang , Wang Minghua , Zhou Qijie , Zheng Tanghong 
Published: September 2021

Abstract
Adsorption functionalized poly(ionic liquid)s could be thiol-ene click synthesized within surfactant-free ionic liquid microemulsions. However, the influence of the mole fraction of pendant enes on the as-prepared polymer is still unclear. Herein, the influence of the mole fraction of pendant enes on the molecular structure, surface morphology, thermostability and adsorption performance of poly(ionic liquid)s were investigated in detail. To characterize the as-prepared polymers, FTIR, NMR, TGA, DSC, SEM and UV–vis were used, and the adsorption isotherm/kinetics studies were carried out. The results show that the mole fraction of pendant enes had a significant difference on the characterization of poly(ionic liquid)s. The lower mole fraction of pendant enes donated lower T10% value, slower degradation rates and lower Tg, and the value of 0.30 was the boundary of forming structure with various beading sizes and structure with various irregularly shaped apertures. In addition, poly(ionic liquid)s with different mole fraction of pendant enes all showed excellent adsorption performance to DR, also indicate remarkable potential in the application of dying wastewater treatment.
Efficient Detection of Multiple FBG Wavelength Peaks using Matched Filtering Technique
Authors: Kumar Sunil 
Published: September 2021

Abstract
We propose an efficient technique for FBG peak detection based on matched filtering technique. The matched filtering process is based on resonance point estimation between a standard reference spectral signal and a reflected spectrum of FBG. The desired peak wavelength and corresponding peak intensity are predicted by determining of the cross-correlation between the FBG signal and 3rd derivative of the reference signal. The peak wavelength and intensity are found from the zero-crossing points of the cross-correlation function. The Mexican-hat wavelet function is chosen as the reference spectral signal due to its narrow shape. The proposed algorithm can suitably be used for multiple peak detection when several FBGs are cascaded and if the FBG signal is weak and noisy.
Itaconate Inhibits TET DNA Dioxygenases to Dampen Inflammatory Responses
Authors: Ye Dan , Chen Leilei , Morcelle Carmen , Cheng Zhouli , Chen Xiufei , Xu Yanping , Gao Yajing , Song Jun-Bin , Li Zhijun , Smith Matthew , Shi Miao , Zhu Yezhang , Zhou Neng , Cheng Meng , He Chenxi , Liu Kwei-Yan , Lu Guoping , Zhang Lei , Zhang Cheng , Zhang Jinye , Sun Yiping , Qi Tuan , Lyu Yingying , Ren Zhi-Zhong , Tan Xian-Ming , Lan Fei , Liu Ying , Yang Hui , Duan Caiwen , Chang Xing , Zhou Yufeng , Shen Li , Baldwin Albert , Guan Kun-Liang , Xiong Yue 
Published: September 2021

Abstract
The immune-response gene 1 (IRG1) plays a key role in anti-pathogen defense, as deletion of Irg1 in mice causes severe defects in response to bacterial and viral infection, and decreased survival1, 2. IRG1 transcription is rapidly induced by pathogen infection and inflammatory conditions primarily in cells of myeloid lineage3. IRG1 encodes a mitochondrial metabolic enzyme, aconitate decarboxylase 1 (ACOD1), that catalyzes the decarboxylation of cis-aconitate to produce the anti-inflammatory metabolite itaconic acid (ITA)4. Several molecular processes are affected by ITA, including succinate dehydrogenase (SDH) inhibition5, resulting in succinate accumulation and metabolic reprogramming6, 7, and alkylation of protein cysteine residues, inducing the electrophilic stress response mediated by NRF2 and IκBζ8, 9 and impairing aerobic glycolysis10. However, the mechanisms by which ITA exerts its profound anti-inflammatory effect still remains to be fully elucidated. Here, we show that ITA is a potent inhibitor of the TET family DNA dioxygenases, which catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) during the process of active DNA demethylation. ITA binds to the same site of α-ketoglutarate (α-KG) in TET2, inhibiting its catalytic activity. Lipopolysaccharides (LPS) treatment, which induces Irg1 expression and ITA accumulation, inhibits Tet activity in macrophages. Transcriptome analysis reveals TET2 is a major target of ITA in suppressing LPS-induced genes, including those regulated by NF-κB and STAT signaling pathways. In vivo, ITA decreases 5hmC, reduces LPS-induced acute pulmonary edema and lung and liver injury, and protects mice against lethal endotoxaemia in a manner that is dependent on the catalytic activity of Tet2. Our study thus identifies ITA as an immune modulatory metabolite that selectively inhibits TET enzymes to dampen the inflammatory response.
Enhancement of concrete performance via mixed limestone and granite powders
Authors: Zeng Hao , Zhang Jin , Zhang Kai 
Published: September 2021

Abstract
The granite and limestone powders are commonly exploited as a replacement for cement; however, the effects of different mixing dosages of them on the mechanical properties and durability of concrete have not been scrutinized carefully. Under different environmental conditions, the compressive strength of the specimens is measured using cube compressive, splitting tensile, freeze-thaw cycles, and sulfate immersion tests. The phase composition of hydration products and microstructure is evaluated by SEM scanning analysis. The results indicate that the composite mixture of granite and limestone powders shows a complementary synergistic effect and improves the mechanical properties, freeze-thaw resistance, and sulfate erosion resistance of the concrete. The best values for the mechanical properties and freeze-thaw resistance are obtained when the dosages of granite and limestone powders in order are 10% and 5%. For the case of granite and limestone powders equal to 10% and 15%, respectively, the best sulfate erosion resistance is reported.
Spectral Detector CT-Derived Pulmonary Perfusion Maps And Pulmonary Parenchyma Characteristics For The Semiautomated Classification of Pulmonary Hypertension
Authors: Gertz Roman Johannes , Gerhardt Felix , Kröger Jan Robert , Shahzad Rahil , Caldeira Liliana , Kottlors Jonathan , Hokamp Nils Große , Maintz David , Rosenkranz Stephan , Bunck Alexander Christian 
Published: September 2021

Abstract
Objectives: To evaluate the usefulness of spectral detector CT (SDCT)-derived pulmonary perfusion maps and pulmonary parenchyma characteristics for the semiautomated classification of pulmonary hypertension (PH).Methods: A total of 162 consecutive patients with right heart catheter (RHC)-proven PH of different etiologies as defined by the Nice classification who underwent CT pulmonary angiography (CTPA) on SDCT and 20 patients with an invasive rule-out of PH were included in this retrospective study. Semiautomatic lung segmentation into normal and malperfused areas based on iodine content as well as automatic, virtual noncontrast-based emphysema quantification were performed. Corresponding volumes, histogram features and the ID SkewnessPerfDef-Emphysema-Index (O-index) accounting for the ratio of ID distribution in malperfused lung areas and the proportion of emphysematous lung parenchyma were computed and compared between groups.Results: Patients with PH showed a significantly greater extent of malperfused lung areas as well as stronger and more homogenous perfusion defects. In Nice class 3 and 4 patients, ID skewness revealed a significantly more homogenous ID distribution in perfusion defects than in all other subgroups. The b-index allowed for further subclassification of subgroups 3 and 4 (p < 0.001), identifying patients with chronic thromboembolic PH (CTEPH, subgroup 4) with high accuracy (AUC: 0.92, 95%-CI, 0.85-0.99).Conclusion: Abnormal pulmonary perfusion in PH can be detected and quantified by semiautomated SDCT-based pulmonary perfusion maps. ID skewness in malperfused lung areas, and the j-index allow for a classification of PH subgroups, identifying Nice class 3 and 4 patients with high accuracy, independent of reader expertise.
Ninety Days and In-Hospital Mortality after Gastrointestinal and Hepatopancreatic Biliary Surgery- A Case Series Analysis.
Authors: vasavada bhavin bhuendra , patel Hardik 
Published: September 2021

Abstract
Aim: The aim was to do a retrospective analysis and audit of our 90 days and in-hospital mortality after gastrointestinal and hepatopancreatic biliary surgery performed in our department and analyze factors predicting it.Patients and methods:All patients who underwent gastrointestinal and hepatopancreatic biliary surgery in our department in the last 3 years were evaluated for 90 days postoperative and in-hospital mortality and various factors affecting it. Categorical values were analyzed using the chi-square test or fisher's exact test wherever appropriate. Continuous variables were analyzed using the student t-test for parametric data and Mann Whitney U test for nonparametric data after skewness and kurtosis analysis. Multivariate analysis was done using logistic regression analysis. A p-value less than 0.05 was considered statistically significant. Statistical analysis was done using SPSS version 23(IBM).Results:412 patients underwent gastrointestinal and hepatobiliary surgery in the last 3 years at our institute. Ninety days all-cause mortality was 5.8%, all-cause in-hospital mortality was around 4.6%. 90 days mortality in elective and emergency surgeries were respectively 3.2% and 18%. In-hospital mortality in elective and emergency surgeries were respectively 2.35% and 15.2%. On multivariate analysis age, nontechnical complications, open surgery, and emergency surgery independently predicted 90 days mortality. On multivariate analysis age, acute kidney injury, non-procedural complications, and emergency surgeries independently predicted in-hospital mortalities.Conclusion:Age, non-technical complications, open surgery, and emergency surgeries are independently associated with 90 days mortality, and age, acute kidney injury, non-procedural complications, and emergency surgery independently predict in-hospital mortality.
Development and Evaluation of an Electronic Nursing Documentation System
Authors: Shafiee Mohsen , Shanbehzadeh Mostafa , Nassari Zeinab , Kazemi-Arpanahi Hadi 
Published: September 2021

Abstract
Introduction:
nursing documentation is a critical aspect of the nursing care workflow. There is a varying degree in how detailed nursing reporting is described in scientific literature and care practice, and no uniform structured documentation is given.
Aims
This study aimed to describe the process of designing and evaluating the content of an electronic nursing documentation system to provide consistent and unified reporting in this context.
Methods
A four-step sequential methodological approach was utilized. The Minimum Data Set (MDS) development process consisting of two phases, as follows: A literature review was performed to attain an exhaustive overview of relevant elements of nursing and map the available evidence underpinning the development of the MDS. Second, the data included from the literature review were analyzed using a two-round Delphi study with content validation by an expert panel. Next, the electronic nursing system (ENS) was developed according to the finalized MDS, and finally, its performance was evaluated by involved the end-users.
Results
The proposed MDS was divided into administrative and clinical sections; including nursing assessment and nursing diagnosis process. Then, a web-based system with modular and layered architecture was designed based on derived MDS. Finally, to evaluate it, a survey by participating 150 registered nurses (RNs) was conducted and the positive impacts and negative impacts of the system were identified.
Conclusion
The developed system is suitable for the documentation of patient care in nursing care plans. However, nurses need further training in documenting patient care according to the nursing process, and in using the standard reporting templates to increase patient safety and improve documentation.
Src Family Kinases Activity is Required for Transmitting Purinergic P2X7 Receptor Signaling in Cortical Spreading Depression and Neuroinflammation
Authors: Nie Lingdi , Ma Dongqing , Quinn John P , Wang Minyan 
Published: September 2021

Abstract
Background Purinergic P2X7 receptor plays a key role in migraine pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling in migraine remains unclear. This study explores the hypothesis that P2X7 receptor transmits signaling to Src family kinases (SFKs) during cortical spreading depression (CSD) and CSD-induced neuroinflammation. Methods CSD was recorded using electrophysiology in rats, and intrinsic optical imaging in mouse brain slices. Cortical IL-1β and TNFα mRNA expression were detected using qPCR. Glutamate release in mouse brain slices was detected using glutamate assay. Results The data showed that systematic deactivation of SFKs by PP2 reduced cortical susceptibility to CSD in rats and CSD-induced IL-1b and TNF-a gene expression in rat ipsilateral cortices. Consistently, in mouse brain slices, inhibition of SFKs activity by saracatinib and P2X7 receptor by A740003 similarly reduced cortical susceptibility to CSD. When the interaction of P2X7 receptor-SFKs was disrupted by TAT-P2X7, a marked reduction of cortical susceptibility to CSD, CSD-induced IL-1b gene expression and glutamate release were observed in mouse brain slices. The reduced cortical susceptibility to CSD by TAT-P2X7 was restored by NMDA and disrupting Fyn-NMDA interaction using TAT-Fyn (39-57), but not disrupting Src-NMDA receptor using TAT-Src (40-49), reduced cortical susceptibility to CSD. Furthermore, activation of P2X7 receptor by BzATP restored the TAT-Fyn (39-57)-reduced cortical susceptibility to CSD. Conclusion This study reveals that SFKs activity mediates P2X7 receptor pore formation facilitating CSD propagation, CSD-induced neuroinflammation and glutamate release, of particular relevance to migraine.
Cranial autonomic symptoms: prevalence, phenotype and laterality in migraine and two potentially new symptoms
Authors: Karsan Nazia , Nagaraj Karthik , Goadsby Peter J 
Published: September 2021

Abstract
BackgroundWhilst cranial autonomic symptoms (CAS) are typically associated with the trigeminal autonomic cephalalgias (TAC’s), they have also been reported in migraine. Identification and understanding of these symptoms in migraine is important to ensure timely diagnosis and effective management. MethodsMigraineurs seen within our tertiary headache service between 2014-2018 ( n =340): cohort one, and a separate cohort of headache patients seen between 2014-May 2021 reporting voice change and/or throat swelling as CAS were selected ( n =64); cohort two. We examined, as a service evaluation, our records regarding age, sex, diagnosis, headache and CAS frequency and laterality as acquired from the first consultation, during which a detailed headache history is taken by a trained physician. ResultsCohort 1: Mean age 43 (range 14-94, SD 15). The most common diagnosis was chronic migraine (78%). Median monthly headache frequency was 26 days (IQR 15-75). At least one CAS was reported in 74%, with a median of two (IQR 0-3). The most common were nasal congestion (32%), lacrimation (31%) and aural fullness (25%). Most patients reported unilateral headache (80%) and strictly unilateral CAS (64%). There was a positive association between headache and CAS laterality (ꭓ 2 1 = 20.7, P < 0.001), with a positive correlation between baseline headache frequency and number of CAS reported ( r = 0.11, P = 0.047). Cohort two: mean age 49 (range 23-83, SD 14). Diagnoses were chronic migraine (50%), chronic cluster headache (11%), undifferentiated continuous lateralised headache (9%), SUNCT/SUNA (8%), hemicrania continua (8%), episodic migraine (8%), episodic cluster headache (3%) and trigeminal neuropathies (3%). Most (89%) described trigeminal distribution pain; 25% involving all three divisions. Throat swelling was reported by 54, voice change by 17, and both by 7. The most common CAS reported were lacrimation ( n = 47), facial swelling ( n = 45) and rhinorrhoea ( n = 37). There was significant agreement between the co-reporting of throat swelling (ꭓ 2 1 = 7.59, P = 0.013) and voice change (ꭓ 2 1 = 6.49, P = 0.02) with aural fullness. ConclusionsCAS are common in migraine, are associated with increasing headache frequency and tend to co-lateralise with headache. Voice change and throat swelling should be recognized as possible parasympathetically-mediated CAS. They may be co-associated and associated with aural fullness, suggesting a broadly somatotopic endophenotype.
Enhancement of Electrochromic Properties of Polyaniline Induced By Copper Ions
Authors: Gao Xiaohui , Qin Ting , Deng Lianwen , Zhang Pin , Tang Min , Li Chen , Xie Haipeng , Huang Shengxiang 
Published: September 2021

Abstract
Driven by the urgent need for adaptive infrared (IR) electrochromic devices, the improvement of electrochromic properties based on polyaniline (PANI) conducting polymers has become one of the research focuses. In recent years, the doping strategy has been proven to efficiently increase the IR modulation ability of PANI, but only limited to the acid species. Herein, the effects of copper ions on the structure and electrochromic properties of polyaniline were investigated. Compared to the pure polyaniline, the Cu-doped PANI porous films show better IR modulation ability. With the increasing concentration of copper ions, the emittance variation (∆ε) of Cu-doped PANI films exhibits a trend in volcanic pattern due to the critical role of the polarons and bipolarons. The optimal IR emissivity (ε) modulation obtained on Cu-doped PANI films shows the ∆ε modulation of 0.35 and 0.3 in the wavelength range of 8–14 µm and 2.5–25 µm, superior to previous reported pure sulfuric acid-doped PANI. Furthermore, a flexible IR electrochromic device was fabricated with the present Cu-doped PANI porous films. The modulation of the emittance variation varied between 0.513 and 0.834 (∆ε = 0.32 in ranges of wavelength 8–12 µm), suggesting the great potential for applications in military camouflage and intelligent IR thermal management.
Respiratory outcomes after six months of hospital discharge in patients affected by COVID-19: a prospective cohort
Authors: Prestes Gabriele da Silveira , Simon Carla Sasso , Walz Roger , Ritter Cristiane , Pizzol Felipe Dal 
Published: September 2021

Abstract
Background
Considering millions of people affected by COVID-19, long-lasting sequelae can significantly impact health worldwide. Data from prospective studies in lower-middle-income countries on persistent lung dysfunction secondary to COVID-19 are lacking. This work aims to determine risk factors and the impact of persistent lung dysfunctions in COVID-19 survivors.
Methods
observational and prospective cohort of patients admitted to a tertiary hospital from June 2020 to November 2020. Persistence of chest computed tomography (CT) scan alterations, desaturation in the six-minute walk test (6MWT), forced expiratory volume in one second (FEV1), lung carbon monoxide diffusion (DLCO), and maximum inspiratory pressure (MIP) were measured six months after hospital discharge. Additionally, the Barthel index (BI) and the Modified Medical Research Council (mMRC) Dyspnea Scale were used to determine the impact of lung dysfunction in activities of daily living (ADL).
Results
It was included 44 patients. Sixty percent had persistent lung CT scan abnormalities. From 18 to 43 percent of patients had at least one pulmonary function dysfunction, a decrease in FEV1 was the least prevalent (18%), and a reduction in DCLO and MIP was the most frequent (43%). In general, female gender, comorbidity index, and age were associated with worse lung function. Additionally, the presence of lung dysfunction could predict worse BI (r-square 0.28) and mMRC (r-square 0.32).
Conclusion
Long-term lung dysfunction is relatively common in survivors from severe COVID-19 and impacts negatively on ADL and the intensity of dyspnea, similar to studies in high-income countries.
Strain-induced Localization-delocalization Transition on a Lieb Ribbon Lattice
Authors: Román-Cortés Diego , Fadic Guillermo , Cid-Lara Christofer , Guzmán-Silva Diego , Real Bastián , Vicencio Rodrigo A. 
Published: September 2021

Abstract
Ribbon lattices are kind of transition systems in between one and two dimensions, and their study is crucial to understand the origin of different emerging properties. In this work, we study a Lieb ribbon lattice and the localization-delocalization transition occurring due to a reduction of lattice distances (compression) and the corresponding flat band deformation. We observe how above a critical compression ratio the energy spreads out and propagates freely across the lattice, therefore transforming the system from being a kind of insulator into a conductor. We implement an experiment on a photonic platform and show an excellent agreement with the predicted phenomenology. Our findings suggest and prove experimentally the use of compression or mechanical deformation of lattices to switch the transport properties of a given system.
MiR30a Inhibits Inflammation by Targeting Klf14 in Autoimmune Hepatitis
Authors: Yuan Xiaofeng , Pan Shunwen , Li Mingliang , Quan Li , Zhang Kouxing , Bi Xiaogang 
Published: September 2021

Abstract
MiR30a plays diverse roles in inflammatory diseases, including autoimmune hepatitis (AIH). Klf14 is associated with the inflammation in AIH. We investigated whether miR30a exerts its regulatory function via Klf14. Concanavalin A (Con A)-induced AIH mice were infected with a miR30a agomir or antagomir. MiR30a expression was quantified using qRT-PCR. TargetScan and luciferase reporter assays were used to predict the relationship between miR30a and Klf14. Liver inflammation was evaluated by measuring serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, performing histology, and measuring mRNA expressions of inflammatory cytokines and Klf14 by qRT-PCR, protein of Klf14 by western blotting, and Tregs by FACS. MiR30a was downregulated in the hepatocytes (HCs) of AIH mice, which was negatively associated with the liver inflammation. MiR30a overexpression alleviated the inflammation, whereas downregulation of endogenous miR30a aggravated it. The mRNA and protein level of Klf14 were inversely correlated with the miR30a expression. The luciferase reporter assay validated the relationship between Klf14 and miR30a. Moreover, the frequency of Tregs was consistently correlated with the expression of miR30a. MiR30a may play an essential role in AIH, and its ability to regulate the inflammatory responses may, at least partially, be mediated by targeting Klf14 to modulate Tregs.