bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of summit visits on bilateral trade: Empirical evidence from China
Authors: Fan Jianting , Lu Bo 
Published: August 2021

AbstractThe relationship between international trade and politics is very close, but we know little about the effects of summit visits on trade. This article divides summits into visits by top‐level and secondary leaders, based on manually collect and collate data; inspects the outward and inward visits between China and other countries and examines the relationship between summit visits and bilateral trade using panel data covering 163 countries from 2001 to 2014. The study finds that (1) both inward and outward visits promote exports, although the effect on imports is unclear; (2) the higher the level of the summit leaders, the greater the promotion effect (the visit effect of China's top‐level leaders is especially prominent); (3) reciprocal summit visits between China and developing countries have a greater trade promotion effect; (4) the promotion effect of China's leaders on exports has time‐leading and ‐lagging effects, and the effect of summit visits is different for different categories of export products.
Reviewer Acknowledgements (Vol. 7, No. 3)
Authors: Willianms Ellery 
Published: August 2021

Business and Management Studies (BMS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether BMS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 7, Number 3 Abdul-Kahar Adam, University of Education, Winneba, GhanaAndrzej Niemiec, Poznań University of Economics and Business, PolandAshford Chea, Benedict College, USAIulia Cristina Muresan, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, RomaniaIza Gigauri, St. Andrew the First-Called Georgian University, GeorgiaJason Caudill, King University, USAJulia Stefanova, Bulgarian Academy of Sciences, BulgariaKonstantinos N. Malagas, University of the Aegean, GreeceLucie Andreisová, University of Economics in Prague, CzechMarica Ion Dumitrasco, Academy of Sciences of Moldova, MoldovaPaduloh Paduloh, Bhayangkara Jakarta Raya University, IndonesiaSandeep Kumar, Tecnia Institute of Advanced Studies, Affiliated to GGSIP University Delgi, IndiaZeki Atıl Bulut, Dokuz Eylul University, Turkey
Patient navigation programs for people with dementia, their caregivers, and members of their care team: a scoping review protocol
Authors: Doucet Shelley , Luke Alison , Anthonisen Grailing , Kelly Katherine J. , Goudreau Alex , MacNeill A. Luke , MacNeill Lillian 
Published: August 2021

ABSTRACT

Objective:
The objective of this review is to map the literature on the characteristics, barriers, and faciliators of patient navigation programs for people with dementia, their caregivers, and/or members of their care team across all settings.

Introduction:
Patient navigation refers to a model of care that helps guide people through the health care system, matching their unmet needs to appropriate resources, services, and programs. Patient navigation may be beneficial to people with dementia because this is a population that frequently faces fragmented and uncoordinated care and has individualized care needs.

Inclusion criteria:
This review will focus on patient navigation programs for people living with dementia, their caregivers, and/or members of their care team, while excluding programs that do not explicitly focus on dementia. It will include patient navigation across all settings, delivered in all formats, and administered by all types of navigators, as long as the program is aligned with this article's definition of patient navigation, while excluding case management.

Methods:
This review will be conducted in accordance with JBI methodology for scoping reviews. The MEDLINE, CINAHL, PsycINFO, Embase, and ProQuest Nursing and Allied Health databases will be searched for published articles. Two independent reviewers will screen articles for relevance against the inclusion criteria. The results will be presented in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews flow diagram, and the extracted data will be presented in both tabular and narrative format.
Contribution of orbital forcing and Deccan volcanism to global climatic and biotic changes across the Cretaceous-Paleogene boundary at Zumaia, Spain
Authors: Gilabert Vicente , Batenburg Sietske J. , Arenillas Ignacio , Arz José A. 
Published: August 2021

AbstractUntangling the timing of the environmental effects of Deccan volcanism with respect to the Chicxulub impact is instrumental to fully assessing the contributions of both to climate change over the Cretaceous-Paleogene boundary (KPB) interval. Despite recent improvements in radiometric age calibrations, the accuracy of age constraints and correlations is insufficient to resolve the exact mechanisms leading to environmental and climate change in the 1 m.y. across the KPB. We present new high-resolution planktic foraminiferal, geochemical, and geophysical data from the Zumaia section (Spain), calibrated to an updated orbitally tuned age model. We provide a revised chronology for the major carbon isotope excursions (CIEs) and planktic foraminiferal events and test temporal relationships with different models of the eruptive phases of the Deccan Traps. Our data show that the major CIEs near the KPB, i.e., the late Maastrichtian warming event (66.25–66.10 Ma) and the Dan-C2 event (65.8–65.7 Ma), are synchronous with the last and the first 405 k.y. eccentricity maximum of the Maastrichtian and the Danian, respectively, and that the minor Lower C29n event (65.48–65.41 Ma) is well constrained to a short eccentricity maximum. Conversely, we obtained evidence of abrupt environmental change likely related to Deccan volcanism at ca. 65.9 Ma, based on a bloom of opportunistic triserial guembelitriids (Chiloguembelitria). The orbital, isotopic, and paleobiological temporal relationships with Deccan volcanism established here provide new insights into the role of Deccan volcanism in climate and environmental change in the 1 m.y. across the KPB.
Landslide hypothesis for the origin of Haleakala volcano's crater and great valleys, Hawaii
Authors: Bishop Kim M. 
Published: August 2021

Abstract
Active Haleakala volcano on the island of Maui is the second largest volcano in the Hawaiian Island chain. Prominently incised in Haleakala's slopes are four large (great) valleys. Haleakala Crater, a prominent summit depression, formed by coalescence of two of the great valleys. The great valleys and summit crater have long been attributed solely to fluvial erosion, but two significant enigmas exist in the theory. First, the great valleys of upper Keanae/Koolau Gap, Haleakala Crater, and Kaupo Gap are located in areas of relatively low annual rainfall. Second, the axes of some valley segments are oblique for long distances across the volcanic slopes. This study tested the prevailing erosional theory by reconstructing the volcano's topography just prior to valley incision. The reconstruction produces a belt along the volcano's east rift zone with a morphology that is inconsistent with volcanic aggradation alone, but it is readily explained if it is assumed the surface was displaced along scarps formed by a giant landslide on Haleakala's northeastern flank. Although the landslide head location is well defined, topographic evidence is lacking for the toe and lateral margins. Consequently, the slope failure is interpreted as a sackung-style landslide with a zone of deep-seated distributed shear and broad surface warping downslope of the failure head. Maximum downslope displacement was likely in the range of 400–800 m. Capture of runoff at the headscarps formed atypically large streams that carved Haleakala's great valleys and explains their existence in low-rainfall areas and their slope-oblique orientations. Sackung-style landslides may be more prevalent on Hawaiian volcanoes than previously recognized.
Detrital zircon provenance and depositional links of Mesozoic Sierra Nevada intra-arc strata
Authors: Attia Snir , Paterson Scott R. , Saleeby Jason , Cao Wenrong 
Published: August 2021

Abstract
A compilation of new and published detrital zircon U-Pb age data from Permo-Triassic to Cretaceous intra-arc strata of the Sierra Nevada (eastern California, USA) reveals consistent sedimentary provenance and depositional trends across the entire Sierra Nevada arc. Detrital zircon age distributions of Sierra Nevada intra-arc strata are dominated by Mesozoic age peaks corresponding to coeval or just preceding arc activity. Many samples display a spread of pre-300 Ma ages that is indistinguishable from the detrital age distributions of pre-Mesozoic prebatholithic framework strata and southwestern Laurentian continental margin deposits. Synthesis of detrital zircon age data with tectonostratigraphic constraints indicates that a marine to subaerial arc was established in Triassic time, giving way to widespread shallow- to deep-marine deposition in latest Triassic to Early Jurassic time that continued until the emergence of the arc surface in the Early Cretaceous. No data presented herein require the existence of Mesozoic exotic terranes and/or outboard arcs that were previously hypothesized to have been accreted to the Sierra Nevada. We conclude that Sierra Nevada intra-arc strata formed within a coherent depositional network that was intimately linked to the southwestern United States Cordilleran margin throughout the span of Mesozoic arc activity.
Discomfort, pain and fatigue levels of 160 cyclists after a kinematic bike-fitting method: an experimental study
Authors: Scoz Robson Dias , Amorim Cesar Ferreira , Espindola Thiago , Santiago Mateus , Mendes Jose Joao Baltazar , Oliveira Paulo Rui de , Ferreira Luciano Maia Alves , Brito Romulo Nolasco 
Published: August 2021

ObjectiveTo analyse rider’s subjective responses after a standardised bicycle ergonomic adjustment method.MethodsExperimental study of 160 healthy, amateur mountain bikers analysed previously and 30 days after a bike-fitting session. The main outcome measures were subjective comfort level (Feeling Scale, FEEL), fatigue (OMINI Scale) and pain (Visual Analogue Scale, VAS).ResultsAll variables demonstrated statistical significance between groups pre and post bike-fit session (p<0001). FEEL, OMNI and VAS-knee demonstrated large effect sizes (d=1.30; d=1.39 and d=0.86, respectively). VAS-hands, VAS-neck and VAS-back indicated moderate effect size (d=0.58; d=0.52 and d=0.43, respectively). VAS-groin and VAS-ankle indicated a small size effect (d=0.46 and d=0.43, respectively).ConclusionsOverall discomfort, fatigue and pain in healthy mountain biker adults improved according to all three scales. The major improvements in pain levels were detected on the knee, hands, back and neck compared with presession values. Groin and ankle pain had smaller improvements but were still significant. Future clinical trials should address the bias effects of this experimental study.
Emergent universe in $$D \ge 4$$ dimensions with dynamical wormholes
Authors: Paul Bikash Chandra 
Published: August 2021

AbstractWe present a flat emergent universe (EU) in Einstein gravity with non-linear equation of state (nEoS) in the usual four and in higher dimensions. The EU is assumed to evolve from an initial Einstein’s static universe (ESU) in the infinite past. For a homogeneous Ricci scalar we determine the shape function and obtain a new class of dynamical wormholes that permits EU. The nEoS $$p= A\rho -B \sqrt{\rho _o \rho }$$

p
=
A
ρ
-
B

ρ
o

ρ

is equivalent to three different cosmic fluids which is identified with barotropic fluid for a given A. We obtain EU models in flat, closed and open universes and tested the null energy condition (NEC). At the throat of the wormhole which is recognized as the seed of ESU, we tested the NEC for a given size of the neck. As the EU evolves from an asymptotic past and approaches $$t=0$$

t
=
0

, it is found that NEC does not respect. This triggers the onset of interactions at $$t=t_i$$

t
=

t
i

, and a realistic flat EU scenario can be obtained in four and in higher dimensions. The origin of the ESU at the throat of the wormhole is also explored via a gravitational instanton mechanism. We compare the relative merits of dynamical wormholes for implementing EU.
Liquid Biopsy for Cancer Detection: Clinical and Epidemiologic Considerations
Authors: Wentzensen Nicolas , Clarke Megan A. 
Published: August 2021

Abstract
Detection of circulating nucleic acids, also referred to as liquid biopsy, has been evaluated for detection of cancer in a variety of settings. We describe important clinical and epidemiologic considerations for liquid biopsy applications in cancer early detection and for monitoring of cancer recurrence.
See related article by Jeannot et al., p. 5869
Current Advances and Trends inKRASTargeted Therapies for Colorectal Cancer
Authors: Teo Michelle Yee Mun , Fong Jung Yin , Lim Wan Ming , In Lionel Lian Aun 
Published: August 2021

AbstractKirsten Rat Sarcoma (KRAS) gene somatic point mutations is one of the most prominently mutated proto-oncogenes known to date, and accounts for approximately 60% of all colorectal cancer cases. One of the most exciting drug development areas against colorectal cancer is the targeting of undruggable kinases and kinase-substrate molecules, although whether and how they can be integrated with other therapies remains a question. Current clinical trial data have provided supporting evidence on the use of combination treatment involving MEK inhibitors and either one of the PI3K inhibitors for patients with metastatic colorectal cancer to avoid the development of resistance and provide effective therapeutic outcome rather than using a single agent alone. Many clinical trials are also ongoing to evaluate different combinations of these pathway inhibitors in combination with immunotherapy for patients with colorectal cancer whose current palliative treatment options are limited. Nevertheless, continued assessment of these targeted cancer therapies will eventually allow patients with colorectal cancer to be treated using a personalized medicine approach. In this review, the most recent scientific approaches and clinical trials targeting KRAS mutations directly or indirectly for the management of colorectal cancer are discussed.
Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes
Authors: Aoyagi Yasushige , Hayashi Yoshihiro , Harada Yuka , Choi Kwangmin , Matsunuma Natsumi , Sadato Daichi , Maemoto Yuki , Ito Akihiro , Yanagi Shigeru , Starczynowski Daniel T. , Harada Hironori 
Published: August 2021

Abstract

Ineffective hematopoiesis is a fundamental process leading to the pathogenesis of myelodysplastic syndromes (MDS). However, the pathobiological mediators of ineffective hematopoiesis in MDS remain unclear. Here, we demonstrated that overwhelming mitochondrial fragmentation in mutant hematopoietic stem cells and progenitors (HSC/P) triggers ineffective hematopoiesis in MDS. Mouse modeling of CBL exon deletion with RUNX1 mutants, previously unreported comutations in patients with MDS, recapitulated not only clinically relevant MDS phenotypes but also a distinct MDS-related gene signature. Mechanistically, dynamin-related protein 1 (DRP1)–dependent excessive mitochondrial fragmentation in HSC/Ps led to excessive reactive oxygen species production, induced inflammatory signaling activation, and promoted subsequent dysplasia formation and impairment of granulopoiesis. Mitochondrial fragmentation was generally observed in patients with MDS. Pharmacologic inhibition of DRP1 attenuated mitochondrial fragmentation and rescued ineffective hematopoiesis phenotypes in mice with MDS. These findings provide mechanistic insights into ineffective hematopoiesis and indicate that dysregulated mitochondrial dynamics could be a therapeutic target for bone marrow failure in MDS.

Significance:
We demonstrated that excessive mitochondrial fragmentation is a fundamental pathobiological phenomenon that could trigger dysplasia formation and ineffective hematopoiesis in MDS. Our findings provide mechanistic insights into ineffective hematopoiesis and suggest dysregulated mitochondrial dynamics as a therapeutic target for treating MDS.
This article is highlighted in the In This Issue feature, p. 1
Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry
Authors: Gallo Francesco , Gallone Guglielmo , Kim Won-Keun , Reifart Jörg , Veulemans Verena , Zeus Tobias , Toggweiler Stefan , De Backer Ole , Søndergaard Lars , Mangieri Antonio , Khokhar Arif , De Marco Federico , Regazzoli Damiano , Reimers Bernhard , Muntané-Carol Guillem , Estévez-Loureiro Rodrigo , Espino Antonio , Moscarelli Marco , Armario Xavier , Mylotte Darren , Gorla Riccardo , Bhadra Oliver Daniel , Conradi Lenard , Marroquin Donday Luis Alfonso , Nombela-Franco Luis , Barbanti Marco , Reddavid Claudia , Criscione Enrico , Brugaletta Salvatore , Regueiro Ander , Pérez-Fuentes Pedro , Nicolini Elisa , Piva Tommaso , Tzanis Giorgos , Rodes-Cabau Josep , Colombo Antonio , Giannini Francesco 
Published: August 2021

Background:
An increased degree of aortic angulation (AA) represents a challenging feature for bioprosthesis positioning. Whether AA has an impact on procedural outcomes of contemporary self-expanding valves remains unsettled. The aim of this study was to evaluate the impact of AA on procedural outcomes of transcatheter aortic valve replacement with contemporary self-expanding valves.

Methods:
The HORSE (Horizontal Aorta in Transcatheter Self-Expanding Valves) is an international, retrospective registry including 3862 consecutive patients undergoing transcatheter aortic valve replacement with either Evolut R/PRO (n=1959) or ACURATE neo (n=1903) devices. Patients undergoing Evolut R 34 mm implantation were excluded as no comparable prosthesis size for ACURATE neo is available. AA was evaluated with preprocedural computed tomography, and its impact on device success was evaluated.

Results:

In the overall population, AA did not have any impact upon device success, also when adjusting for in-study outcome predictors (odds ratio for 1° increment, 0.99 [95% CI, 0.98–1.01],
P
=0.306). However, increased AA was associated with lower device success with use of the Evolut R/PRO valves (odds ratio, 0.97 [95% CI, 0.95–0.99];
P
=0.004), but not the ACURATE neo valves (odds ratio, 1.00 [95% CI, 0.98–1.03],
P
=0.304). The best AA cutoff value predicting device success was 49° (47% of the study cohort). Among patients with AA≥49°, Evolut R/PRO valves were associated with lower device success as compared to the ACURATE neo valve (inverse probability weighting odds ratio, 0.62 [95% CI, 0.46–0.83];
P
=0.002).

Conclusions:
Horizontal aorta, as defined by an AA ≥49°, is a common feature among transcatheter aortic valve replacement candidates and predicts device failure of the Evolut R/PRO valves, but not of the ACURATE neo valve. AA may be an effect modifier of the association between self-expanding valve type and device success.
Post-Operative Wound Infection by Multiple Zoonotic Organisms
Authors: Albert Matthew , Wright Jesse P. , Ocariz Brandon 
Published: August 2021

Rhodococcus hoagii (formerly Rhodococcus equi), originally isolated from equine species, is primarily transmitted through inhalation of contaminated aerosols such as dust and even breath of infected livestock. Pasteurella multocida is a common cause of cellulitis secondary to canine and feline bites. These are 2 zoonotic microbes that can present with potentially life-threatening, systematic illness in immunocompromised patients. In this brief report, we delineate the clinical course of a 42-year-old post-operative patient (status post-elective exploratory laparotomy, extensive adhesiolysis, and excision of enterocutaneous fistula with creation of an end ileostomy) who developed multiple infections involving these two zoonotic microbes. The patient is an enthusiast of exotic animals with an extensive occupational history as a zookeeper. She was determined to be HIV negative but has a significant history of Crohn’s disease managed with systemic immunosuppressive therapy. This case highlights her unusual constellation of post-operative infections and her subsequent medical management.
A Qualitative Study of the Social and Lived Experiences of Homebound Older Adults
Authors: Cheng Joyce M. , Batten George P. , Yao Nengliang (Aaron) 
Published: August 2021

Objective: The number of homebound older adults is increasing in the United States. We aimed to examine their social and lived experiences and to understand their perspectives on their situation, feelings, and coping mechanisms. Methods: We conducted a cross-sectional qualitative study using semi-structured interviews with 18 older homebound individuals in Central Virginia. Results: Homebound older adults experienced both physical and mental health challenges that restricted their ability to participate in activities of daily living, recreation, and social interactions. Participants often felt dependent, helpless, lonely, and socially isolated. Those who communicated regularly with friends, family, and health care providers reported positive benefits from these interactions. Discussion: Participants faced challenges to their physical, emotional, and mental well-being. Our findings might help clinicians, policymakers, and community organizations understand how to better support homebound older adults. We should provide educational opportunities, respect their autonomy, and implement initiatives to address their isolation and loneliness.
Tumor lysis Syndrome in a Patient with Metastatic Breast Cancer Treated with Alpelisib
Authors: Handy Caitlin , Wesolowski Robert , Gillespie Michelle , Lause Michael , Sardesai Sagar , Williams Nicole , Grimm Michael , Kassem Mahmoud , Ramaswamy Bhuvaneswari 
Published: August 2021

Purpose: Tumor lysis syndrome (TLS) is a rare but life-threatening phenomenon that occurs mainly in patients with aggressive hematologic or highly chemotherapy sensitive solid tumors such as high-grade neuroendocrine carcinoma or testicular cancer. Tumor lysis syndrome is exceedingly rare in hormone receptor-positive, HER2-negative breast cancer. Furthermore, TLS following treatment with alpelisib, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor used to treat PIK3CA-mutated (gene encoding p110α subunit of PI3K), hormone receptor positive advanced breast cancer, has never been described in patients with nonhematologic malignancies. Methods: In the following case, we present a patient with hormone receptor-positive, HER2-negative, PIK3CA-mutated metastatic breast cancer who developed TLS 12 days after starting fulvestrant and alpelisib. Results: Patient was promptly treated with improvement in her renal function to baseline without requiring renal replacement therapy. Alpelisib was resumed at a reduced dose with no further complications. Conclusion: Through this case, we discuss the potential complications of TLS and the importance of prompt recognition and treatment.