bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heritage hands and tastes of the pandemic
Authors: Tracy Megan 
Published: May 2021

AbstractThe revitalization of fermentation projects during COVID-19 raises questions about the preservation of the pandemic’s material and ephemeral effects – a topic that heritage policy is well equipped to engage. These activities also emphasize the necessity of engaging with heritage practices as a kind of care, encompassing both methods of safekeeping and practices of empathy. In addition, heritage ferments prove “good to think” around themes of loss and preservation, the interpretation of novel viruses through traditional food practices, and the coupling of heritage to microbes. Connecting microbes with heritage allows us to consider points of overlap: as bearers of patrimony with cultural and material lineages, as central to heritage tastes, and as open to geographical indications or other protections to further a kind of microbial resource management. Despite the pandemic’s devastating impact, consideration of heritage ferments points to both emancipatory and constraining outcomes for our post-pandemic future.
Ianus Augustus, Caput Viae (Mengíbar, Spain): An interprovincial monumental border in Roman Hispania
Authors: Bellón Ruiz Juan Pedro , Lechuga Chica Miguel Ángel , Moreno Padilla María Isabel , Gutiérrez-Rodríguez Mario 
Published: May 2021

AbstractRecent research undertaken as part of the Iliturgi Project has located the remains of an Early Imperial building complex linked to the Via Augusta. They include the foundations of an arch and a monumental platform whose size and characteristics allow it to be identified as the Ianus Augustus, a monumental complex near the River Baetis that marked the limit between the Roman provinces of Baetica and Tarraconensis. Its location makes it a reference point for our knowledge of the ancient geography of Hispania and for understanding Roman interprovincial frontiers. Geophysical prospections in its surroundings have also revealed the possible remains of a bridge across the river.
Transcatheter closure of ventricular septal defects in children less than 10 kg: experience from a tertiary care referral hospital in Eastern India
Authors: Roy Mahua , Gangopadhyay Debasree , Goyal Noopur , Murthy Savita , Nandi Debabrata , Bandyopadhyay Biswajit , Dutta Joyeeta 
Published: May 2021

AbstractObjective:To assess the feasibility of percutaneous transcatheter device closure of ventricular septal defects in children weighing less than 10 kg.Background:Although percutaneous transcatheter device closure of ventricular septal defect is a well-established method of treatment in older children and adolescents, there is limited data on device closure in small children weighing less than 10 kg. We present our institutional experience of transcatheter VSD closure in children weighing less than 10 kg.Method:Medical records were reviewed for 16 children, who were selected for device closure of ventricular septal defects based on the inclusion criteria.Results:Out of 65 patients with a diagnosis of ventricular septal defect, 16 children less than 10 kg were attempted for percutaneous device closure. In 13 patients, the device was successfully released, and 3 patients needed surgical closure of the defect. Mean age and weight of the patients were 17.3 ± 12.7 months and 6.8 ± 3.2 kg, respectively. Mean defect size was 6 mm (range 3–10). There was no incidence of device embolisation or heart block or death. Five patients had residual left-to-right shunt immediately after the device release, which got closed by the first month’s follow-up. We had one accidental perforation of right ventricular free wall at the time of crossing of the defect, which was successfully repaired surgically.Conclusion:Percutaneous device closure of ventricular septal defect in small children with weight below 10 kg is feasible with good short-term outcome. Careful patient selection is essential for procedural success and to avoid complications.
The Standard Doctrine of Creation in Zoroastrian Pahlavi Texts
Authors: AHMADI AMIR 
Published: May 2021

AbstractThe main scheme of creation in Zoroastrian Pahlavi literature is adopted from the Young Avesta. In this scheme Ohrmazd creates the world in the manner of a skillful craftsman who conceives of the form of his product and then fashions it in matter. The number of the constituents of the world and the sequence in which they are created are already fixed in the Avesta. Pahlavi authors draw on Greek philosophical tradition to rationalise their account of the creation of the world. The article also explores some of the complications that their philosophical elaboration of the Avestan scheme occasions.
Pregnancy and lactation after Roux-en-Y gastric bypass worsen nonalcoholic fatty liver disease in obese rats and lead to differential programming of hepatic de novo lipogenesis in offspring
Authors: Bertasso Iala Milene , Pietrobon Carla Bruna , Ribeiro Rosane Aparecida , Soares Gabriela Moreira , Oliveira Janaina Chaves de , Alegre-Maller Ana Claudia Paiva , Boschero Antonio Carlos , Araújo Allan Cezar Faria , Guimarães Ana Tereza Bittencourt , Bonfleur Maria Lúcia , Balbo Sandra Lucinei 
Published: May 2021

AbstractMaternal obesity increases the risk of nonalcoholic fatty liver disease (NAFLD) in offspring. The Roux-en-Y gastric bypass (RYBG) is effective for achieving weight loss and ameliorates NAFLD. To determine whether these benefits are maintained after pregnancy and/or lactation, and whether they modulate hepatic morphofunction in the next generation, we evaluated hepatic lipid metabolism in Western diet (WD)-obese female rats that underwent RYGB and in their F1 offspring at adulthood. Female Wistar rats consumed a WD from 21 to 130 days of age, before being submitted to RYGB (WD-RYGB-F0) or SHAM (WD-SHAM-F0) operations. After 5 weeks, these females were mated with control male breeders, and the male and female F1 offspring were identified as WD-RYGB-F1 and WD-SHAM-F1. WD-RYGB-F0 dams exhibited lower serum lipids levels, but severe hepatic steatosis and pathological features of advanced liver injury. The hepatic proteins involved in lipogenesis were reduced in WD-RYGB-F0, as were the genes related to β-oxidation and bile acids (BAs). Although the female and male WD-RYGB-F1 groups did not exhibit hepatic steatosis, the livers of female WD-RYGB-F1 demonstrated higher amounts of lipogenic genes and proteins, while male WD-RYGB-F1 presented a similar downregulation of lipogenic factors to that seen in WD-RYGB-F0 dams. In contrast, maternal and offspring groups of both sexes displayed reductions in the expressions of genes involved in BAs physiology and gluconeogenesis. As such, RYGB aggravates NAFLD after pregnancy and lactation and induces a gender-dependent differential expression of the hepatic lipogenesis pathway in offspring, indicating that female WD-RYGB-F1 may be an increased risk of developing NAFLD.
The Observation and SD‐WACCM Simulation of Planetary Wave Activity in the Middle Atmosphere During the 2019 Southern Hemispheric Sudden Stratospheric Warming
Authors: Lee Wonseok , Song In‐Sun , Kim Jeong‐Han , Kim Yong Ha , Jeong Se‐Heon , Eswaraiah S. , Murphy D. J. 
Published: May 2021

AbstractA sudden stratospheric warming (SSW) is an extremely rare event in the Southern Hemisphere (SH), but occurred in early September 2019. From the Antarctic meteor radar (MR) stations, Davis (68.6˚S, 77.9˚E) and King Sejong Station (62.2˚S, 58.8˚W), quasi 10‐day oscillations were clearly observed in the zonal mesospheric winds before the central date (DOY 253) of the SSW. From the northern low‐latitude Tirupati (13.6˚N, 79.4˚E) MR, a strong wave activity with a period of ∼6 days was detected in the zonal winds right after the central date. This oscillation is also seen in the geopotential height measurements from the Microwave Limb Sounder (MLS) on board the Aura satellite near the Tirupati region. To elucidate the possible source of the quasi 6‐day wave (Q6DW), we use a specified dynamics version of the Whole Atmosphere Community Climate Model (SD‐WACCM) constrained by the reanalysis data from the surface to 50 km. The simulation results show that the amplitude of the westward and equatorward propagating Q6DW was enhanced after the SSW central date in the MLT region, and the Q6DW can be attributed to the baroclinic/barotropic instability in the SH high‐latitude mesosphere where the divergence of Eliassen‐Palm flux occurred. Thus, we suggest that the Q6DW activity observed by the Tirupati MR and MLS originated from the SH high‐latitude mesospheric region. Both the observation and the simulation results clearly demonstrate that the 2019 SH SSW affected not only the high‐latitude MLT region but also the low‐latitude MLT region.
Transverse Mixing in Rivers With Longitudinally Varied Morphology
Authors: Gond L. , Mignot E. , Le Coz J. , Kateb L. 
Published: May 2021

AbstractImproving the quantification of the transverse mixing coefficient in rivers is essential for a better estimation of pollutant dispersion. This coefficient is evaluated from tracing experiments or from semi‐empirical equations assuming uniform flow conditions. This assumption, verified for laboratory experiments, is questionable for river studies. For example, piedmont rivers exhibit nonuniform flows due to their longitudinal morphological variations. This work aims at studying the longitudinal variability of the transverse mixing coefficient in a river with longitudinally varied morphology and the overlooked impact of the flow nonuniformity on the coefficient’s values. Tracing experiments were conducted in the Durance River in France using slug injections and concentration measurements made at the cross‐sections delineating homogeneous sub‐reaches. Using the well‐known 1D transverse diffusion model, values of the transverse mixing coefficient are determined for all consecutive sub‐reaches. These values substantially vary along the studied river, with stronger mixing efficiency at pools and complex riffles and weaker mixing efficiency in straight sub‐reaches with emerging obstacles. The dimensionless transverse mixing coefficient is strongly related to a parameter quantifying the deviation from flow‐uniformity, i.e., indicating flow acceleration, deceleration or a succession of both within the sub‐reaches. While usual formulas from the literature fail to predict our empirical results, a new equation including the flow nonuniformity parameter fits our experimental data with high accuracy. After further validation, such equation may be used for predicting the transverse mixing coefficient in rivers with longitudinally varied morphology.
Global Simulation of the Jovian Magnetosphere: Transitional Structure From the Io Plasma Disk to the Plasma Sheet
Authors: Tanaka T. , Ebihara Y. , Watanabe M. , Fujita S. , Kataoka R. 
Published: May 2021

AbstractJupiter has a strong magnetic field, and a huge magnetosphere is formed through the solar wind‐Jupiter interaction. The generated magnetosphere–ionosphere system is reproduced based on the 9‐component Magnetohydrodynamics (MHD) and the current conservation in the ionosphere. Assuming Io plasma emission rate 1.4 t/sec, this paper reproduces self‐consistently global magnetic configuration, generations of the field‐aligned current (FAC) and aurora, formation of the Io plasma disk at 8–20 RJ, plasma corotation, instability in the plasma disk, transition from the Io plasma disk to the plasma sheet at 20–150 RJ, and the plasmoid ejection. The rotating Io plasma in the disk forms instabilities that promotes radial diffusion. H+ is supplied from the ionosphere along high‐latitude magnetic field lines and mixed with heavy ions around 15–20 RJ. Beyond 20 RJ, mixed plasma diffuses further outward by the centrifugal force that can exceed magnetic tension. In the ionosphere, the main oval occurs at 13.7°–15.5° colatitude. The Io disk is inner side of magnetic field lines traced from the low‐latitude edge of the main oval. Along magnetic field lines, the main oval is mapped from the outer edge of the Io disk to the entire plasma sheet accompanying rotation delay. Due to the corotation limit, convection is accompanied by plasmoid ejection. Back reaction of plasmoid ejection affects even transport process in the Io disk. The downward FAC occurs in the polar cap showing variability. The region of externally driven Dungey convection seems quite narrow.
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis
Authors: Fang Jian , Wang Hui , Zhou Yuping , Zhang Hui , Zhou Huiting , Zhang Xiaohong 
Published: May 2021

AbstractUlcerative colitis (UC) is a chronic recurrent intestinal inflammatory disease characterized by high incidence and young onset age. Recently, there have been some interesting findings in the pathogenesis of UC. The mucus barrier, which is composed of a mucin complex rich in O-glycosylation, not only provides nutrients and habitat for intestinal microbes but also orchestrates the taming of germs. In turn, the gut microbiota modulates the production and secretion of mucins and stratification of the mucus layers. Active bidirectional communication between the microbiota and its ‘slimy’ partner, the mucus barrier, seems to be a continually performed concerto, maintaining homeostasis of the gut ecological microenvironment. Any abnormalities may induce a disorder in the gut community, thereby causing inflammatory damage. Our review mainly focuses on the complicated communication between the mucus barrier and gut microbiome to explore a promising new avenue for UC therapy.
Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1
Authors: Kang Hyo Jae , Lee Kyung Jin , Woo Jisu , Kim Jiyeon , Kim Yun Kyu , Lee Chang-Hoon , Yoo Chul-Gyu , Lee Kyoung-Hee 
Published: May 2021

AbstractPulmonary fibrosis is a progressive and lethal lung disease characterized by the proliferation and differentiation of lung fibroblasts and the accumulation of extracellular matrices. Since pulmonary fibrosis was reported to be associated with adenosine monophosphate-activated protein kinase (AMPK) activation, which is negatively regulated by cereblon (CRBN), we aimed to determine whether CRBN is involved in the development of pulmonary fibrosis. Therefore, we evaluated the role of CRBN in bleomycin (BLM)-induced pulmonary fibrosis in mice and in transforming growth factor-beta 1 (TGF-β1)-induced differentiation of human lung fibroblasts. BLM-induced fibrosis and the mRNA expression of collagen and fibronectin were increased in the lung tissues of wild-type (WT) mice; however, they were significantly suppressed in Crbn knockout (KO) mice. While the concentrations of TGF-β1/2 in bronchoalveolar lavage fluid were increased via BLM treatment, they were similar between BLM-treated WT and Crbn KO mice. Knockdown of CRBN suppressed TGF-β1-induced activation of small mothers against decapentaplegic 3 (SMAD3), and overexpression of CRBN increased it. TGF-β1-induced activation of SMAD3 increased α-smooth muscle actin (α-SMA) and collagen levels. CRBN was found to be colocalized with AMPKα1 in lung fibroblasts. CRBN overexpression inactivated AMPKα1. When cells were treated with metformin (an AMPK activator), the CRBN-induced activation of SMAD3 and upregulation of α-SMA and collagen expression were significantly suppressed, suggesting that increased TGF-β1-induced activation of SMAD3 via CRBN overexpression is associated with AMPKα1 inactivation. Taken together, these data suggest that CRBN is a profibrotic regulator and maybe a potential target for treating lung fibrosis.
Advantages of robotic assistance over a manual approach in simulated subretinal injections and its relevance for gene therapy
Authors: Ladha Reza , Meenink Thijs , Smit Jorrit , de Smet Marc D. 
Published: May 2021

AbstractSubretinal injection is a method for gene delivery to treat genetic diseases of the photoreceptors and retinal pigment epithelium. A reflux-free subretinal injection is important to allow effective, safe, and cost-effective gene therapy to the retina. We report on a comparison between manual and robotic assistance in simulated subretinal injections using an artificial retina model. Nine surgeons carried out the procedure with and without the Preceyes Surgical System, using an OPMI Lumera 700 Zeiss surgical microscope equipped with intra-operative optical coherence tomography. Success in creating a bleb without reflux, injection duration, drift, tremor, and increase in the diameter of the puncture hole were analyzed. Robotic assistance improved drift (median 16 vs 212 µm), tremor (median 1 vs 18 µm), enlargement of the retinal hole, and allowed for prolonged injection times (median 52 vs 29 sec). Robotic assistance allowed higher rate of bleb formation (8/9 vs 4/9 attempts) with a moderate reduction in reflux (7/9 vs 8/9 attempts) in this artificial model. Robotic assistance can significantly contribute to subretinal injections and provide quantifiable parameters in assessing surgical and clinical success of novel retinal gene therapies.
A pilot study to investigate if the mesenteric circumferential location of colon cancer affects survival when compared to the anti-mesenteric side
Authors: Horwell E. , Sagias F. 
Published: May 2021

AbstractColorectal cancer is a leading cause of death in the western world. The main datum that is employed to guide treatment and prognosis are related to the pathological stage and the genetics of the cancer. Recent electron-microscopic study of the colonic border has suggested a difference between the micro-anatomy of the mesenteric border11, compared to the anti-mesenteric. With colorectal cancer increasing in incidence, the more information that we can employ to guide and tailor patient centred management, the better. A pilot study to test the hypothesis that the circumferential location on the colonic wall, mesenteric or anti-mesenteric, has an impact on the mortality rate associated with right-sided colon cancer. All patients undergoing a right hemicolectomy for non-metastatic adenocarcinoma between 2010 and 2013 were included (155 patients in total). T and N stage were recorded. There was no statistical difference between the groups for age or sex. Survival rates were then calculated according to the location of the cancer and analysed using Kaplan–Meir survival calculations. 100 patients were included in the final analysis. 90 patients had cancer on the antimesenteric border. The T and N stage were not statistically different between the two groups. The mean all-cause survival was 44 months for the mesenteric group and 77 for the antimesenteric (P = 0.002). Disease free survival was 41 versus 60 months accordingly (P = 0.021). Mesenteric cancer appears to have a shorter survival time, and may be a good candidate for future prognostication and treatment algorithms. Interesting this survival difference is observed even with a lower average T stage in the mesenteric group. The histological recording of the circumferential location is a zero cost and easy metric to record.
Discovery of primary prostate cancer biomarkers using cross cancer learning
Authors: Zhou Kaiyue , Arslanturk Suzan , Craig Douglas B. , Heath Elisabeth , Draghici Sorin 
Published: May 2021

AbstractProstate cancer (PCa), the second leading cause of cancer death in American men, is a relatively slow-growing malignancy with multiple early treatment options. Yet, a significant number of low-risk PCa patients are over-diagnosed and over-treated with significant and long-term quality of life effects. Further, there is ever increasing evidence of metastasis and higher mortality when hormone-sensitive or castration-resistant PCa tumors are treated indistinctively. Hence, the critical need is to discover clinically-relevant and actionable PCa biomarkers by better understanding the biology of PCa. In this paper, we have discovered novel biomarkers of PCa tumors through cross-cancer learning by leveraging the pathological and molecular similarities in the DNA repair pathways of ovarian, prostate, and breast cancer tumors. Cross-cancer disease learning enriches the study population and identifies genetic/phenotypic commonalities that are important across diseases with pathological and molecular similarities. Our results show that ADIRF, SLC2A5, C3orf86, HSPA1B are among the most significant PCa biomarkers, while MTRNR2L1, EEPD1, TEPP and VN1R2 are jointly important biomarkers across prostate, breast and ovarian cancers. Our validation results have further shown that the discovered biomarkers can predict the disease state better than any randomly selected subset of differentially expressed prostate cancer genes.
Optimization of whole-brain rabies virus tracing technology for small cell populations
Authors: Roelofs Theresia J. M. , Menting-Henry Shanice , Gol Lieke M. , Speel Annelijn M. , Wielenga Vera H. , Garner Keith M. , Luijendijk Mieneke C. M. , Hennrich Alexandru A. , Conzelmann Karl-Klaus , Adan Roger A. H. 
Published: May 2021

AbstractThe lateral hypothalamus (LH) is critically involved in the regulation of homeostatic energy balance. Some neurons in the LH express receptors for leptin (LepRb), a hormone known to increase energy expenditure and decrease energy intake. However, the neuroanatomical inputs to LepRb-expressing LH neurons remain unknown. We used rabies virus tracing technology to map these inputs, but encountered non-specific tracing. To optimize this technology for a minor cell population (LepRb is not ubiquitously expressed in LH), we used LepRb-Cre mice and assessed how different titers of the avian tumor virus receptor A (TVA) helper virus affected rabies tracing efficiency and specificity. We found that rabies expression is dependent on TVA receptor expression, and that leakiness of TVA receptors is dependent on the titer of TVA virus used. We concluded that a titer of 1.0–3.0 × 107 genomic copies per µl of the TVA virus is optimal for rabies tracing. Next, we successfully applied modified rabies virus tracing technology to map inputs to LepRb-expressing LH neurons. We discovered that other neurons in the LH itself, the periventricular hypothalamic nucleus (Pe), the posterior hypothalamic nucleus (PH), the bed nucleus of the stria terminalis (BNST), and the paraventricular hypothalamic nucleus (PVN) are the most prominent input areas to LepRb-expressing LH neurons.
Virtual splint registration for electromagnetic and optical navigation in orbital and craniofacial surgery
Authors: Schreurs Ruud , Baan F. , Klop C. , Dubois L. , Beenen L. F. M. , Habets P. E. M. H. , Becking A. G. , Maal T. J. J. 
Published: May 2021

AbstractIn intra-operative navigation, a registration procedure is performed to register the patient’s position to the pre-operative imaging data. The registration process is the main factor that determines accuracy of the navigation feedback. In this study, a novel registration protocol for craniofacial surgery is presented, that utilizes a virtual splint with marker points. The accuracy of the proposed method was evaluated by two observers in five human cadaver heads, for optical and electromagnetic navigation, and compared to maxillary bone-anchored fiducial registration (optical and electromagnetic) and surface-based registration (electromagnetic). The results showed minimal differences in accuracy compared to bone-anchored fiducials at the level of the infra-orbital rim. Both point-based techniques had lower error estimates at the infraorbital rim than surface-based registration, but surface-based registration had the lowest loss of accuracy over target distance. An advantage over existing point-based registration methods (bone-anchored fiducials, existing splint techniques) is that radiological imaging does not need to be repeated, since the need for physical fiducials to be present in the image volume is eradicated. Other advantages include reduction of invasiveness compared to bone-achnored fiducials and a possible reduction of human error in the registration process.