bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wild Animals and Duties of Assistance
Authors: Jalagania Beka 
Published: March 2021

AbstractIs there a moral requirement to assist wild animals suffering due to natural causes? According to the laissez-faire intuition, although we may have special duties to assist wild animals, there are no general requirements to care for them. If this view is right, then our positive duties toward wild animals can be only special, grounded in special circumstances. In this article I present the contribution argument which employs the thought that the receipt of benefits from wild animals is one such kind of special circumstance. If this argument is correct, then the circle of moral agents required to assist some wild animals is significantly widened.
Probabilistic Modelling for Incorporating Uncertainty in Least Cost Path Results: a Postdictive Roman Road Case Study
Authors: Lewis Joseph 
Published: March 2021

AbstractThe movement of past peoples in the landscape has been studied extensively through the use of least cost path (LCP) analysis. Although methodological issues of applying LCP analysis in archaeology have frequently been discussed, the effect of DEM error on LCP results has not been fully assessed. Due to this, the reliability of the LCP result is undermined, jeopardising how well the method can confidently be used to model past movement. To strengthen the reliability of LCP results, this research proposes the use of Monte Carlo simulation as a method for incorporating and propagating the effects of error on LCP results. Focusing on vertical error, random error fields are calculated and incorporated into the documented and reproducible LCP modelling process using the R packageleastcostpath. By graphically communicating the impact of vertical error using probabilistic LCPs, uncertainty in the results can be taken into account when interpreting LCPs. The method is applied to a Roman road case study, finding that the incorporation of vertical error results in the identification of multiple ‘least cost’ routes within the landscape. Furthermore, the deviation between the roman road and the probabilistic LCP suggests that the location of the roman road was influenced by additional factors other than minimising energy expenditure. This research finds that the probabilistic LCP derived using Monte Carlo simulation is a viable method for the graphical communication of the uncertainty caused by error within the input data used within the LCP modelling process. Therefore, it is recommended that probabilistic LCPs become the default approach when modelling movement using input data that contains errors.
Modelling inelastic Granular Media Using Dynamical Density Functional Theory
Authors: Goddard B. D. , Hurst T. D. , Ocone R. 
Published: March 2021

AbstractWe construct a new mesoscopic model for granular media using Dynamical Density Functional Theory (DDFT). The model includes both a collision operator to incorporate inelasticity and the Helmholtz free energy functional to account for external potentials, interparticle interactions and volume exclusion. We use statistical data from event-driven microscopic simulations to determine the parameters not given analytically by the closure relations used to derive the DDFT. We numerically demonstrate the crucial effects of each term and approximations in the DDFT, and the importance of including an accurately parametrised pair correlation function.
Corporate governance and IPO underpricing: evidence from the italian market
Authors: Teti Emanuele , Montefusco Ilaria 
Published: March 2021

AbstractThis paper aims to analyse the impact of firms’ corporate governance characteristics on the degree of first-day returns (i.e., underpricing) in the Italian initial public offering (IPO) market. In particular, this work investigates the impacts of the characteristics of boards of directors (BoDs) and ownership structure on the underpricing of newly offered shares. By studying a sample of 128 Italian IPOs between 2000 and 2016, it is concluded that corporate governance characteristics affect the degree of first-day returns following a company’s IPO. More specifically, the size of the BoD negatively affects underpricing, while the ownership of institutional investors and board members has a positive effect on the degree of underpricing. Conversely, no significant evidence is found with regard to board independence, the number of female directors in the boardroom, the implementation of stock option plans and ownership concentration.
Osteoblast role in the pathogenesis of rheumatoid arthritis
Authors: Berardi S. , Corrado A. , Maruotti N. , Cici D. , Cantatore F. P. 
Published: March 2021

AbstractIn the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritis, osteoarthritis, osteoporosis, alterations in osteoblast growth, differentiation and activity play a role. In particular, in rheumatoid arthritis bone homeostasis is perturbed: in addition to stimulating the pathologic bone resorption process performed by osteoclasts in course of rheumatoid arthritis, proinflammatory cytokines (such as Tumor Necrosis factor-α, Interleukin-1) can also inhibit osteoblast differentiation and function, resulting in net bone loss. Mouse models of rheumatoid arthritis showed that complete resolution of inflammation (with maximal reduction in the expression of pro-inflammatory factors) is crucial for bone healing, performed by osteoblasts activity. In fact, abnormal activity of factors and systems involved in osteoblast function in these patients has been described. A better understanding of the pathogenic mechanisms involved in osteoblast dysregulation could contribute to explain the generalized and focal articular bone loss found in rheumatoid arthritis. Nevertheless, these aspects have not been frequently and directly evaluated in studies. This review article is focused on analysis of the current knowledge about the role of osteoblast dysregulation occurring in rheumatoid arthritis: a better knowledge of these mechanisms could contribute to the realization of new therapeutic strategies.
EDXRF for screening micronutrients in lentil and sorghum biofortification breeding programs
Authors: Guild Georgia E. , Stangoulis James C. R. 
Published: March 2021

Abstract
Background and aims
This study explores the use of energy dispersive x-ray fluorescence (EDXRF) for screening micronutrient concentrations in lentil and sorghum grain for biofortification breeding programs.

Methods
Lentil and sorghum seed was provided from biofortification breeding programs and analysed with inductively coupled plasma mass spectrometry (ICP-MS) to determine the reference concentration levels of Ca, Mn, Fe, Cu and Zn. A subset of these samples was used to establish the EDXRF calibration and another subset used for validation of the method.

Results
The results show the EDXRF analyses of the lentil and sorghum are not significantly different to the reference ICP-MS for all elements analysed, except for Mn with %RSD of replicate analysis < 5 % for lentil analysis and < 10 % for sorghum.

Conclusions
EDXRF analysis enables rapid and accurate analysis of Ca, Mn, Fe, Cu and Zn in lentil and sorghum.
The patient journey to diagnosis and treatment of congenital sucrase-isomaltase deficiency
Authors: Smith Heather , Romero Beverly , Flood Emuella , Boney Anne 
Published: March 2021

Abstract
Purpose
Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic disorder characterized by a deficiency of the sucrase-isomaltase (SI) enzyme complex within the brush border membrane of the small intestine. Mutations in the SI gene result in abnormal synthesis and/or incorrect transport of the SI enzyme. Patients with CSID generally have reduced sucrase activity, but levels of isomaltase activity range from absent to almost normal. This study sought to better understand the experience of patients with CSID prior to, during, and after their diagnosis and its subsequent treatment with sacrosidase.

Methods
This was a cross-sectional interview study conducted in conjunction with a longitudinal, observational study of US patients prescribed and taking sacrosidase for at least three consecutive months as treatment for CSID. The observational study included both children and adults.

Results
This qualitative interview study explored the experiences of 43 adult and pediatric patients (n = 8 adults and n = 35 children/adolescents) with CSID pre-, during, and post-diagnosis. Findings suggest that a CSID diagnosis is particularly problematic given the disparate range of more commonly understood gastrointestinal (GI) disorders. After diagnosis and treatment with sacrosidase, participants reported considerable improvement in symptoms and health-related quality of life (HRQL), yet symptoms persist that continue to affect daily life, indicating areas of potential unmet need.

Conclusion
Educating clinicians about CSID may help improve the overall diagnosis experience. As this research is the first of its kind in CSID, additional research, qualitative and quantitative, will be important to furthering the understanding of HRQL impact and unmet need experienced by this population and identifying ways to best meet those needs.
Weighing the costs: the epistemic dilemma of no-platforming
Authors: Peters Uwe , Nottelmann Nikolaj 
Published: March 2021

Abstract‘No-platforming’—the practice of denying someone the opportunity to express their opinion at certain venues because of the perceived abhorrent or misguided nature of their view(s)—is a hot topic. Several philosophers have advanced epistemic reasons for using the policy in certain cases. Here we introduce epistemic considerations against no-platforming that are relevant for the reflection on the cases at issue. We then contend that three recent epistemic arguments in favor of no-platforming fail to factor these considerations in and, as a result, offer neither a conclusive justification nor strong epistemic support for no-platforming in any of the relevant cases. Moreover, we argue that, taken together, our epistemic considerations against no-platforming and the three arguments for the policy suggest that no-platforming poses an epistemic dilemma (i.e., a difficult choice situation involving two equally undesirable options). While advocates and opponents of no-platforming alike have so far overlooked this dilemma, it should be addressed not only to prevent that actual no-platforming decisions create more epistemic harm than good, but also to put us into a better position to justify the policy when it is indeed warranted.
Riparian populations of minnesota reed canarygrass (Phalaris arundinacea) are most likely native, based on SNPs (DArTseqLD)
Authors: Noyszewski Andrzej K. , Anderson Neil O. , Smith Alan G. , Kilian Andrzej , Dalbotten Diana , Ito Emi , Timm Anne , Pellerin Holly , Kubátová Barbora , Kávová Tereza , Januš Vojtěch , Čurn Vladislav , Edwards Keith R. , Bastlová Daša , Květ Jan 
Published: March 2021

AbstractThe native vs. exotic status of reed canarygrass (RCG), a major invasive species of Minnesota wetlands, is unknown. The aim of this study was to investigate this native vs. exotic status to enhance its management. Genetic comparison of wild RCG populations from six Minnesota and six Czech Republic rivers was performed. A total of 2521 polymorphic SNP markers (single nucleotide polymorphisms) were used to evaluate 478 RCG samples across all collections. In the PCoA, all (n = 256) tested extant wild, riparian RCG genotypes from six Minnesota Rivers and six Czech Republic Rivers were genetically distinct, although some SNPs were common in both populations since they are the same species. DAPC analysis also resulted in the formation of two primary clusters separating the Minnesota Rivers and Czech Republic Rivers riparian samples, with little overlap; STRUCTURE analysis also supported this clustering with k = 4 groups as it separated the Czech Republic Rivers populations into three groups, along with Minnesota Rivers. The uniformity of PCoA, DAPC, STRUCTURE, and Evanno results indicates the distinct separation of Minnesota Rivers and Czech Republic Rivers populations. Portions of the genome (specific SNPs) are preserved or in common across continents, as indicated by STRUCTURE similarities. Nonetheless, overall significant SNP differences between the continents indicate that the Minnesota riparian populations are distinct enough from the European (Czech) collections to be delineated as native N. American RCG. PCoA of all the Minnesota RCG collections clustered Minnesota Rivers, Herbarium, Extant Herbarium, Research Field and Native Field collections together. STRUCTURE analysis (k = 2; Evanno) divided these Minnesota collections from the Commercial Field and Cultivars collections. There are two genetically distinct groups of RCG in Minnesota and since the Minnesota Rivers, the Research Field, the Native Field and pre-1930 herbaria collections clustered together, they are most likely native N. American types. Analysis of molecular variance (AMOVA) indicated that the genetic variation was more significant within, rather than among, the RCG populations. Native, historic herbaria types cluster together with all wild RCG river populations in Minnesota, all of which were distinct from those in Central Europe, suggesting native RCG type persistence in N. America. Also, cultivated forage types of RCG are distinct from wild RCG Minnesota river populations. The SNP genetic data shows that riparian Minnesota RCG populations are native. These data will facilitate future management strategies to control RCG as a native, but invasive, species.
Can a Bodily Theorist of Pain Speak Mandarin?
Authors: Nie Chenwei 
Published: March 2021

AbstractAccording to a bodily view of pain, pains are objects which are located in body parts. This bodily view is supported by the locative locutions for pain in English, such as that “I have a pain in my back.” Recently, Liu and Klein (Analysis, 80(2), 262–272, 2020) carry out a cross-linguistic analysis, and they claim that (1) Mandarin has no locative locutions for pain and (2) the absence of locative locutions for pain puts the bodily view at risk. This paper rejects both claims. Regarding the philosophical claim, I argue that a language without locative locutions for pain only poses a limited challenge to the bodily view. Regarding the empirical claim, I identify the possible factors which might have misled Liu and Klein about the locative locutions for pain in Mandarin, and argue that Mandarin has a wide range of locative locutions for pain by conducting a corpus analysis. I conclude that compared to English, Mandarin lends no less, if not more, support to the bodily view of pain.
Plasmonic Coupler and Multiplexer/Demultiplexer Based on Nano-Groove-Arrays
Authors: Udupi Aparna , Madhava Sathish Kumar 
Published: March 2021

AbstractA novel plasmonic unidirectional coupler and its extension to a multiplexer/demultiplexer are proposed and simulated. The proposed structure can be etched adjacent to metal-insulator-metal (MIM) waveguides which can result in considerable reduction in footprint of optical signal processing systems. Simulated results show very good agreement with design. Extinction ratio (ER) of more than 11 dB was achieved for both the coupler as well as the multiplexer/demultiplexer. Crosstalk as well as full width at half maximum (FWHM) was also highly acceptable for the multiplexer/demultiplexer. The proposed structures have an additional attractive feature of being amenable to integration with other relevant functionalities as demonstrated in the results.
Hoffa’s fat pad thickness: a measurement method with sagittal MRI sequences
Authors: Ricatti Giovanni , Veronese Nicola , Gangai Ilaria , Paparella Mariateresa , Testini Valentina , Guglielmi Giuseppe 
Published: March 2021

Abstract
Background
Hoffa’s fat pad is a structure located within the fibrous joint capsule of the knee joint, but outside the synovial cavity. It plays an important biomechanical and metabolic role in knee joint, reducing the impact of forces generated by loading and producing cytokines. Changes in its size can induce modifications in the knee homeostasis. However, a great variability exists regarding its measurements. This work aims to evaluate the reliability of a measurement method of Hoffa’s fat pad dimensions through MRI.

Methods
3T sagittal IW 2D TSE fat-suppressed MRI sequences, taken from the OAI (Osteoarthritis initiative) database, of 191 male and female patients, aged between 40 and 80 years, were analysed; a manual measurement of the thickness of Hoffa’s fat pad of each subject was then performed by two different readers. The interobserver reliability and intraobserver reliability of the measurements were described by coefficient of variation (CV), Pearson correlation and Bland–Altman plots.

Results
All statistical analyses have shown that not significant intra- or interobservers differences were evident (intraobserver CV % for the first observer was 2.17% for the right knee and 2.24% for the left knee, while for the second observer 2.31% for the right knee and 2.24% for the left knee; linear correlation was for the first observer r = 0.96 for the right knee and r = 0.96 for the left knee, while for the second observer r = 0.97 for the right knee and r = 0.96 for the left knee; in addition, the interobserver CV % was 1.25% for the right knee and 1.21% for the left knee and a high interobserver linear correlation was found: r = 0.97 for the right knee and r = 0.96 for the left knee).
All results suggest that this manual measurement method of Hoffa’s fat pad thickness can be performed with satisfactory intra- and interobserver reliability.

Conclusions
Hoffa’s fat pad thickness can be measured, using sagittal MRI images, with this manual method that represents, for his high reliability, an effective means for the study of this anatomical structure.
Quo vadis? Historical distribution and impact of climate change on the worldwide distribution of the Australasian fungus Clathrus archeri (Phallales, Basidiomycota)
Authors: Pietras Marcin , Kolanowska Marta , Selosse Marc-André 
Published: March 2021

AbstractClathrus archeri is a fungus native to Australia and New Zealand that has started to expand into Europe, and it is considered a potentially invasive species. In this study, we examine the historical occurrence, current geographical range and potential future changes in the distribution of C. archeri using worldwide distribution data. Ecological modelling was used to assess the locations of the potential climatic niches of C. archeri within both its native and introduced ranges in the past, present and future. Our study clearly shows that the coverage of suitable habitats of this fungus has decreased since the last glacial maximum, and anthropogenic climate changes are accelerating the process of niche loss. The highest rate of C. archeri range contraction is expected in Australia, where the fungus should be considered a threatened species in the future. Highly valuable habitats will be available in Tasmania and New Zealand. However, a significant expansion rate of C. archeri will still probably be observed in Europe, where the climatic conditions preferred by the fungus will allow its quick expansion northeast into the continent.
Improved strategies to efficiently isolate thermophilic, thermotolerant, and heat-resistant fungi from compost and soil
Authors: Witfeld Frederick , Begerow Dominik , Guerreiro Marco Alexandre 
Published: March 2021

AbstractThermophilic, thermotolerant and heat-resistant fungi developed different physiological traits, enabling them to sustain or even flourish under elevated temperatures, which are life-hostile for most other eukaryotes. With the growing demand of heat-stable molecules in biotechnology and industry, the awareness of heat-adapted fungi as a promising source of respective enzymes and biomolecules is still increasing. The aim of this study was to test two different strategies for the efficient isolation and identification of distinctly heat-adapted fungi from easily accessible substrates and locations. Eight compost piles and ten soil sites were sampled in combination with different culture-dependent approaches to describe suitable strategies for the isolation and selection of thermophilous fungi. Additionally, an approach with a heat-shock treatment, but without elevated temperature incubation led to the isolation of heat-resistant mesophilic species. The cultures were identified based on morphology, DNA barcodes, and microsatellite fingerprinting. In total, 191 obtained isolates were assigned to 31 fungal species, from which half are truly thermophilic or thermotolerant, while the other half are heat-resistant fungi. A numerous amount of heat-adapted fungi was isolated from both compost and soil samples, indicating the suitability of the used approaches and that the richness and availability of those organisms in such environments are substantially high.
Overlooked nitrogen-cycling microorganisms in biological wastewater treatment
Authors: Xu Shaoyi , Wu Xiaolong , Lu Huijie 
Published: March 2021

AbstractNitrogen-cycling microorganisms play key roles at the intersection of microbiology and wastewater engineering. In addition to the well-studied ammonia oxidizing bacteria, nitrite oxidizing bacteria, heterotrophic denitrifiers, and anammox bacteria, there are some other N-cycling microorganisms that are less abundant but functionally important in wastewater nitrogen removal. These microbes include, but not limited to ammonia oxidizing archaea (AOA), complete ammonia oxidation (comammox) bacteria, dissimilatory nitrate reduction to ammonia (DNRA) bacteria, and nitrate/nitrite-dependent anaerobic methane oxidizing (NOx-DAMO) microorganisms. In the past decade, the development of high-throughput molecular technologies has enabled the detection, quantification, and characterization of these minor populations. The aim of this review is therefore to synthesize the current knowledge on the distribution, ecological niche, and kinetic properties of these “overlooked” N-cycling microbes at wastewater treatment plants. Their potential applications in novel wastewater nitrogen removal processes are also discussed. A comprehensive understanding of these overlooked N-cycling microbes from microbiology, ecology, and engineering perspectives will facilitate the design and operation of more efficient and sustainable biological nitrogen removal processes.
The adult sex ratio of European regions predicts female, but not male, subjective well-being
Authors: Richardson Thomas 
Published: March 2021

AbstractIn recent years, researc in subjective well-being has found several ecological factors that may underpin societal differences in happiness. The adult sex ratio, the number of males relative to females in an environment, influences many behaviours in both humans and non-human animals. However, the possible influence of the sex ratio on subjective well-being has received little attention. I investigated the relationship between the adult sex ratio and subjective well-being in over 29,000 respondents from 133 regions of Europe. I find that women report lower subjective well-being in areas with more female-biased sex ratios, but males’ well-being was unaffected. I did not find that the sex ratio influences the sex specific probability of marriage, or marriage rates overall. I also find that increased population density is associated with lower well-being. Drawing from sociological and evolutionary theories, I suggest that results may be due to females’ decreased bargaining power in the dating market.