bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic Artery Infusion of Floxuridine in Combination With Systemic Chemotherapy for Pancreatic Cancer Liver Metastasis: A Propensity Score-Matched Analysis in Two Centers
Authors: Peng Changli , Xu Bin , Xiao Juxiong , Zhou Chunhui , Li Xiaodong , Shi Hongbing , Qiang Weiguang , Wang Tianming , Zhao Jiemin , Liu Fei , Li Gang , Li Haiping , Chen Changyong , Shi Liangrong 
Published: April 2021

AimTo evaluate the efficacy of hepatic artery infusion (HAI) of floxuridine (FUDR) in combination with systemic chemotherapy in patients with pancreatic cancer liver metastases (PCLM).Patients and MethodsWe retrospectively collected clinical data of 347 patients with PCLM who underwent first-line chemotherapy at two Chinese centers between 2012 and 2019. Propensity score matching between patients with and without HAI was performed to compensate for differences in baseline characteristics. Objective response rate (ORR) and overall survival (OS) between groups were compared. HAI pump functionality was recorded.ResultsData of 258 patients (62 patients with HAI and 196 patients without HAI) were used for matching. After 1:1 ratio matching, 62 patients per group were included. The intrahepatic ORR was 66.1% in the HAI group and 22.6% in the non-HAI group (P &lt; 0.001), and the extrahepatic ORR was 25.0 versus 28.9% (P = 0.679). The median OS was significantly longer in HAI group (14.0 versus 10.8 months, P = 0.001). Multivariance COX regression showed HAI led to a decrease in hazard ratio for death by 61.8% (HR = 0.382; 95% CI: 0.252–0.578; P&lt; 0.001). Subgroup analysis revealed that patients without EHM, with higher intrahepatic tumor burden and with synchronous liver metastasis benefited more from HAI. Dysfunction of HAI pump occurred in 5.7% of patients during the period of follow-up.ConclusionsIn patients with PCLM, first-line treatment with HAI FUDR plus SCT resulted in higher intrahepatic response and better OS.
A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe
Authors: Koomen Jeroen V. , Stevens Jasper , Monster-Simons Margje H. , Heerspink Hiddo J. L. , Mol Peter G. M. 
Published: April 2021

Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control. Nonetheless, dose selection of anti-diabetic drugs is typically based solely on glycaemic effects. We evaluated whether off-target drug effects are currently considered for dose justification to regulatory agencies.Methods: In the European Union, anti-diabetic drugs are registered by the European Medicines Agency. We extracted available information regarding dose selection from public assessment reports and marketing application dossiers. Descriptive statistics were used to summarise the extracted information.Results: In total, 14 drugs of three drug classes were included; sodium-glucose co-transporter-2 inhibitors (n = 4), dipeptidyl peptidase-4 inhibitors (n = 4) and glucagon-like peptide-1 receptor agonists (n = 6). For these drugs, 21 dose-finding trials were submitted including results of multiple off-target effects, of which body weight (n = 18) and low-density lipoprotein cholesterol (n = 14) were most frequently reported. Dose-response curves for off-target effects appeared to be different compared to the glycaemic dose-response curve. Glycated hemoglobin (100%) and fasting plasma glucose (42.9%), were used most frequently for the dose justification, but generally off-target effects (&lt;25%) were not.Conclusions: Dose justification to regulatory authorities was mainly based on glycaemic effects. The dose-response relationship for the off-target effects did not necessarily follow the dose-response relationship of the on-target effects suggesting that selection of the optimal anti-diabetic dose could benefit from including off-target effects in the dose selection process as well.
Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity
Authors: Grotell Milo , den Hollander Bjørnar , Jalkanen Aaro , Törrönen Essi , Ihalainen Jouni , de Miguel Elena , Dudek Mateusz , Kettunen Mikko I. , Hyytiä Petri , Forsberg Markus M. , Kankuri Esko , Korpi Esa R. 
Published: April 2021

Mephedrone (4-MMC), despite its illegal status, is still a widely used psychoactive substance. Its effects closely mimic those of the classical stimulant drug methamphetamine (METH). Recent research suggests that unlike METH, 4-MMC is not neurotoxic on its own. However, the neurotoxic effects of 4-MMC may be precipitated under certain circumstances, such as administration at high ambient temperatures. Common use of 4-MMC in conjunction with alcohol raises the question whether this co-consumption could also precipitate neurotoxicity. A total of six groups of adolescent rats were treated twice daily for four consecutive days with vehicle, METH (5 mg/kg) or 4-MMC (30 mg/kg), with or without ethanol (1.5 g/kg). To investigate persistent delayed effects of the administrations at two weeks after the final treatments, manganese-enhanced magnetic resonance imaging brain scans were performed. Following the scans, brains were collected for Golgi staining and spine analysis. 4-MMC alone had only subtle effects on neuronal activity. When administered with ethanol, it produced a widespread pattern of deactivation, similar to what was seen with METH-treated rats. These effects were most profound in brain regions which are known to have high dopamine and serotonin activities including hippocampus, nucleus accumbens and caudate-putamen. In the regions showing the strongest activation changes, no morphological changes were observed in spine analysis. By itself 4-MMC showed few long-term effects. However, when co-administered with ethanol, the apparent functional adaptations were profound and comparable to those of neurotoxic METH.
Survey on the Progression of Myopia in Children and Adolescents in Chongqing During COVID-19 Pandemic
Authors: Wang Wujiao , Zhu Lu , Zheng Shijie , Ji Yan , Xiang Yongguo , Lv Bingjing , Xiong Liang , Li Zhuoyu , Yi Shenglan , Huang Hongyun , Zhang Li , Liu Fangli , Wan Wenjuan , Hu Ke 
Published: April 2021

Background: The Covid-19 pandemic restricts children and adolescents from doing normal daily activities such as playing outdoors and going to school. The incidence and prevalence of myopia have increased during the COVID-19 pandemic. The aim of this study was to investigate and evaluate the impact of the home confinement during the COVID-19 pandemic on the progression of myopia among children and adolescents in Chongqing, China.Methods: The survey was conducted by using stratified samplings. Samples were randomly selected from the 2019 National Student Physique and Health Survey database, and their visual function and refractive data were compared with those in 2020. Vision-related behavior questionnaire including digital screen exposure was applied to investigate the correlation between eye parameter and eye health-related behavior.Results: A total of 1,733 and 1,728 students were enrolled in 2020 and 2019, respectively. The percentage of myopia students was 55.02% in 2020, which was higher than that in 2019 (44.62%). The mean uncorrected visual acuity (UCVA, LogMAR, 0.35 ± 0.42) in 2020 was higher than that in 2019 (0.27 ± 0.36, P &lt; 0.001). The mean spherical equivalent (SE) refraction (−1.94 ± 2.13 D) in 2020 was lower than that in 2019 (−1.64 ± 5.49 D, P &lt; 0.001). For students who used digital devices for online courses, the mean SE in the television group (−1.10 ± 1.49 D) was better than that in the computer group (−2.03 ± 2.37 D, P = 0.0017) and in the cell phone group (−2.02 ± 2.09 D, P = 0.0028). The average duration of online classes (r = −0.27, P &lt; 0.0001), the number of online classes per day (r = −0.33, P &lt; 0.0001), as well as digital screen exposure time (r = −0.20, P &lt; 0.0001) were negatively correlated with SE, and the average time of outdoor activity (r = 0.20, P &lt; 0.0001) was positively correlated with SE.Conclusions: Increased digital screen exposure contributes to myopic progression in children and adolescents of Chongqing during the COVID-19 pandemic. Suitable digital devices should be provided for online classes and outdoor activity should be advocated to prevent myopic pandemic.
Aplicación web para fortalecer la gestión del transporte en la recolección de residuos sólidos urbanos
Authors: Apacani Fernández Carla Claudia 
Published: April 2021

El propósito de la investigación es el desarrollo de una aplicación Web para para fortalecer la gestión del transporte en la recolección de residuos sólidos urbanos de la Empresa Municipal de Aseo Potosí (EMAP). Se parte de un diagnóstico de las necesidades de los usuarios y prestadores de servicio. Se estableció como objeto de estudio al sistema de gestión del transporte en esta empresa. La investigación es proyectiva tecnológica, el diseño es de campo. Las técnicas de recolección de datos son la observación, la encuesta y la entrevista y los instrumentos la guía de observación, el cuestionario y el guion de entrevista. Como resultado se presenta la aplicación Web para la gestión del transporte en EMAP que se construyó aplicando la metodología de gestión de proyectos SCRUM que permite dar respuesta a las necesidades de la empresa.
Study of Municipal Sludge Ash as a Brick Material -A Review
Authors: M Jagadeshwaran , K Vijaya Sundravel 
Published: April 2021

The municipalities produce sludge of different quality and in different quantities. Sludge resulting from municipalities creates problems of disposal. Generally, dewatered sludge’s are disposed of by spreading on the land or by land filling. However, for highly urbanized cities, sludge disposal by land filling might not be appropriate due to land limitation. Incineration might be an alternative solution. However, a substantial amount of ash will be produced after the burning process and must be disposed of by other means. This paper presents the results of the utilization of sludge ash as brick making materials. The different engineering properties were also studied by conducting tests on brick specimens of various mix proportions prepared. It was seen that when percentage of sludge was increased, water requirement as well as water absorption of the bricks increased. But at the same time, compressive strength of the brick decreased. But on addition of cement and fly ash the compressive strength increased and the properties of the bricks improved. Further it can be added that other alternatives like sisal fibres, charcoal husk, lime whose addition shall enhance the properties which can be considered as the scope for future research.
الــــركن المـــــادي لجريمة تجنيد الأطفال في النزاعات المُسلحـــــة
Authors: ابراهيم صباح سامي , جاسم اسراء عبد الصاحب 
Published: April 2021

تعد النزاعات بحكم طبيعتها ظرفاً مناسباً لارتكاب تجاوزات وانتهاكات لحقوق الانسان , وان اكثر الناس تعرضاً لويلاتها واضرارها هم الفئات الضعيفة ولاسيما الاطفال . إذ يعد الاطفال الفئة الاكثر تضرراً في النزاعات المسلحة , وذلك لتعدد وتنوع صور الاعتداء عليهم , الذي يعد تجنيدهم في النزاعات المسلحة احد هذه الصور واخطرها عليهم , لذا فإن استخدام الاطفال في النزاعات المسلحة ليست ظاهرة حديثة تقتصر فقط على النزاعات المسلحة المعاصرة , وانما تم استخدامهم في الحروب القديمة وعبر الازمنة والحضارات المختلفة , الا ان هذه الظاهرة اخذت ابعاداً جديدة في ظل النزاعات المعاصرة , ذلك لان بعض الاطراف المتحاربة باتت تعتبر وجود الاطفال شيئاً اساسياً في صفوفها , كونها فئات يسهل استخدامهم وتجنيدهم في النزاعات المسلحة , إذ لم يعد يقتصر وجودهم على القيام بإدوار مساعدة في تلك النزاعات , وانما باتوا يمارسون ادواراً اساسية فيها تتمثل بحمل الاسلحة والاشتراك في القتال في الصفوف الامامية لتلك النزاعات .
وبذلك تعد جريمة تجنيد الاطفال في النزاعات المسلحة من الجرائم الخطرة وذات الاهمية المتجددة , كونها تشكل انتهاكاً واضحاً وصريحاً لكل القواعد الجنائية الدولية والداخلية والاخلاقية التي تحث على احترام حقوق الاطفال ورعايتهم وتوفير سبل الحماية لهم .
Expansion patterns of single Shockley stacking faults from scratches on 4H-SiC
Authors: Do Euihyeon , Kaneko Mitsuaki , Kimoto Tsunenobu 
Published: April 2021

Abstract
Single Shockley-type stacking faults (1SSFs) in the 4H-SiC epilayer exhibits numerous expansion patterns determined by the relationship between initial basal-plane dislocation (BPD) direction and Burgers vector. In this study, patterns of BPDs and 1SSFs generated by UV illumination near linear scratches on a SiC epilayer were investigated. The correlation between the observed 1SSF patterns and the scratch line directions was discussed by considering shear stress near the scratch lines. This result suggests that it is possible to form 1SSFs with a desired shape by adjusting the components of shear stress through the setting of scribing conditions.
Dependence of dose rate on the sensitivity of the resist under ultra-high flux extreme ultraviolet (EUV) pulse irradiation
Authors: Okamoto Kazumasa , Kawai Shunpei , Ikari Yuta , Hori Shigeo , Konda Akihiro , Ueno Koki , Arai Yohei , Ishino Masahiko , Dinh Thanh-Hung , Nishikino Masaharu , Kon Akira , Owada Shigeki , Inubushi Yuichi , Kinoshita Hiroo , Kozawa Takahiro 
Published: April 2021

Abstract
Efforts are being focused on increasing the power of extreme ultraviolet (EUV) light sources used in semiconductor manufacturing to increase the throughput. As a result, the investigation of the effect of high power sources on resist materials is a critical issue. A chemically amplified resist (CAR) and a non-CAR were irradiated with 13.5 nm EUV high-flux pulses from a soft X-ray free-electron laser (FEL). In the non-CAR, the positive-tone resist (ZEP520A) exhibited lower sensitivity at high irradiation densities, while the negative-tone resist exhibited a higher sensitivity. In addition, the dose rate did not considerably affect the sensitivity of the CAR.
Characteristics of EGFR Gene Mutation in Lung Adenocarcinoma at Adam Malik General Hospital
Authors: Ambarita Novita Margaretta , Soeroso Noni Novisari , Tarigan Setia Putra , Zalukhu Fotarisman 
Published: April 2021

Background: Epidermal growth factor (EGFR) is a transmembrane receptor that plays an important role in the development of cancer phenotypes. Some patients with lung cancer have genetic mutations. Several studies have found a close correlation of EGFR gene mutation with 15-20% of lung adenocarcinoma cases. This study aimed to determine the EGFR profile in adenocarcinoma lung cancer patients at Haji Adam Malik General Hospital.Methods: This was a prospective cohort study conducted at Haji Adam Malik General Hospital, Medan. This study used patients data for 3 years, starting from January 1, 2014 to D1ecember 31, 2016. The sample size in this study was 34 patients. The data were then analyzed using SPSS.Results: All patients were adenocarcinoma lung cancer patients with positive EGFR mutation. There were 9 subjects with EGFR mutation in exon 19; 11 subjects with exon 21 L858R mutation; and 3 subjects with exon 21 L861Q mutation. Meanwhile, there were 3 subjects with uncommon EGFR mutations, namely exon 18 mutation. Majority of subjects with exon 19 mutation were male, aged >60 years, smokers with mixed types of cigarettes and severe brinkmann index. In subjects with exon 21 L858R mutation, most of the patients were male, aged 50-60 years, smokers with mixed cigarette types and severe brinkmann index. The same characteristics were also observed in subjects with exon 18 mutation. However, for exon 21 L861Q mutation, the majority of subjects were female with varying ages, and were not smokers.Conclusion: Most of the study subjects profiles were male, aged over 60 years, smokers, with mixed types of cigarettes, and with severe Brinkman Index. The EGFR mutations most commonly occured in exon 21, followed by exon 19 (ins/del exon 19), exon 18, and a combination of 2 exons.
EVALUATION OF THE POSSIBILITY OF THE PRODUCTION A SOLVENT WITH A LOW CONTENT OF AROMATIC HYDROCARBONS IN JSC «ANHK»
Authors: Bahmatov Mihail , Kuzora Igor' 
Published: April 2021

. In connection with the emerging demand for gasoline solvent with a low content of
aromatic hydrocarbons we carrier out the analysis of intermediate products obtained in JSC " ANHK "
suitable for the producing of the solvent. The most suitable for the separation of the fraction are gaso line fractions producing from the hydrogenation product of the hydrocracking of light vacuum gas oil
and the hydrogenation product of high conversion hydrogenation of the heavy middle distillate frac tions. We performed work on the recovery of a narrow fraction of gasoline solvent and its tests for
compliance with the requirements.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUASAN PELANGGAN PADA JASA TRANSPORTASI PERUSAHAAN OTOBUS BUDIMAN JURUSAN TASIKMALAYA-CIKARANG
Authors: Rismawati  , Ina Ratnasari  
Published: April 2021

Tujuan dari penelitian ini adalah untuk menguji dan menganalisis faktor-faktor apa saja yang mempengaruhi kepuasan pelanggan pada jasa transportasi perusahaan otobus budiman jurusan tasikmalaya-cikarang. Faktor-faktor yang akan dianalisis dalam penelitian ini adalah faktor biaya perjalanan, faktor waktu perjalanan, faktor waktu tunggu, faktor aksesibilitas, faktor kesesuaian, faktor keamanan/keselamatan. Hasil penelitian yang diperoleh dari uji analisis faktor menunjukkan bahwa diperoleh 3 faktor yang berpengaruh paling dominan terhadap kepuasan pelanggan dalam memilih angkutan jasa transportasi umum bus budiman jurusan tasikmalaya-cikarang. faktor-faktor tersebut adalah : faktor biaya perjalanan 36,59%, faktor waktu perjalanan 12,86%, faktor keamanan/keselamatan 7,422%. Faktor yang paling dominan mempengaruhi kepuasan pelanggan adalah faktor biaya perjalanan, faktor waktu perjalanan dan faktor keamanan/keselamatan. sedangkan sisanya dipengaruhi oleh faktor lain yang tidak diteliti.
Kata Kunci : Analisis Faktor, Jasa Transportasi Umum, kepuasan Pelanggan.

The purpose of this study is to examine and analyze the factors that affect customer satisfaction in the transportation services of the Budiman bus company, majoring in Tasikmalaya-Cikarang. The factors that will be analyzed in this study are the travel cost factor, the travel time factor, the waiting time factor, the accessibility factor, the suitability factor, the security/safety factor. The data were obtained from distributing questionnaires to 277 respondents who used the Budiman bus majoring in Tasikmalaya-Cikarang. The data analysis technique used is the scale range technique and the factor analysis technique. The results of the research obtained from the factor analysis test showed that there were 3 factors that had the most dominant influence on customer satisfaction in choosing public transportation services, the Budiman bus majoring in Tasikmalaya-Cikarang. These factors are: travel cost factor 36.59%, travel time factor 12.86%, security/safety factor 7.422%. The most dominant factors affecting customer satisfaction are travel costs, travel time factors and security/safety factors. while the rest is influenced by other factors not examined.
Keywords: Factor Analysis, Public Transportation Services, Customer Satisfaction
SELF CARE PADA PASIEN DIABETES MELITUS DENGAN PENYULIT ULKUS KAKI DIABETIK
Authors: Megayanti Sri Dewi , Suantika, S.Kep.,M.Kep Ns. Putu Inge 
Published: April 2021

ABSTRAKLatar Belakang: Diabetes self-care merupakan perilaku perawatan diri pasien diabetes yang meliputi pengaturan diet, penggunaan insulin, olahraga dan perawatan kaki. Diabetes self-care memiliki efek langsung pada kontrol glikemik dalam terjadinya ulkus kaki diabetic. Skor PEDIS merupakan form pemeriksaan yang digunakan perawat dalam menilai keparahan ulkus kaki. Keterbatasan intervensi ulkus kaki yang diberikan oleh perawat saat ini disebabkan oleh terbatasnya data tentang self-care pada pasien diabetes. Tujuan penelitian mengetahui self-care pasien diabetes dengan komplikasi ulkus kaki menggunakan metode pengukuran skor PEDIS yang teridiri dari pemeriksaan perfusi, luas luka, kedalaman luka, keberadaan infeksi dan sensasi kaki.Metode: Penelitian ini termasuk penelitian kuantitatif, dimana penentuan responden menggunakan teknik Convenience sampling dengan jumlah sampel adalah 125, analisa data yang digunakan dengan metode deskriptif.Hasil: Pada penelitian ini 53,8 % reponden memiliki diabetes self-care yang adekuat dan rata- rata responden memiliki Skor PEDIS 2,08.Kesimpulan: dalam penelitian ini sebagian besar responden memiliki diabetes self-care yang tidak adekuat. Nilai Diabetes self-care dapat digunakan oleh perawat untuk mengetahui tingkat kualitas perawatan diri pasien selama ini sehingga memudahkan dalam menentukan intervensi yang tepat untuk mencegah terajadinya perburukan ulkus kaki. Kata kunci: diabetes mellitus tipe 2, diabetes self-care, dan ulkus kaki diabetik. ABSTRACTBackground: Diabetes self-care is a diabetes patient self-care behavior that includes diet management, insulin use, exercise and foot care. Diabetes self-care has a direct effect on glycemic control in the occurrence of diabetic foot ulcers. The PEDIS score is an examination form that nurses use in assessing the severity of foot ulcers. The limitations of the foot ulcer intervention given by nurses at this time are due to limited data on self-care in diabetic patients. The aim of this study was to determine the self-care of diabetic patients with complications of foot ulcers using the PEDIS score measurement method which consists of examination of perfusion, wound area, wound depth, presence of infection and foot sensation.Methods: This research is a quantitative study, where the determination of the respondents using the convenience sampling technique with a sample size of 125, the data analysis used is the descriptive method.Results: In this study 53.8% of respondents had adequate diabetes self-care and the mean of respondents had a PEDIS score of 2.08. Conclusion: in this study most of the respondents had inadequate self-care diabetes. The value of diabetes self-care can be used by nurses to determine the level of quality of patient self-care so far, making it easier to determine the right intervention to prevent worsening of foot ulcers. Keywords: type 2 diabetes mellitus, diabetes self-care, and diabetic foot ulcers.
Intermedialidad y circulación de los relatos en "Los abrazos rotos" de Pedro Almodóvar
Authors: González Álvarez José Manuel 
Published: April 2021

El presente estudio se propone analizar la génesis, el flujo y el entrecruzamiento de los relatos en Los abrazos rotos (2009) de Pedro Almodóvar. Desde un enfoque postestructuralista se hace énfasis en el complejo entramado de relaciones transtextuales (Genette) que mantienen las narraciones contenidas en la película, en virtud del cual subrayamos el afán del cineasta por urdir un tejido artístico donde lo ficcional se constituye en única realidad al absorber la materia extradiegética. Ello nos lleva a contemplar el film desde la “precedencia de los simulacros” (Baudrillard) y a ponderar la relevancia que allí cobran los continuos espejeos discursivos. En este sentido, destacamos cómo los distintos soportes enunciativos y receptores se alternan y por momentos se homologan (texto, cámara, pantallas de cine, ordenador, televisión….), en un nudo semiótico intrincado donde cada relator o filmador aparece a su vez enmarcado. En suma, se desgranan desde la narratología los rasgos fundamentales del discurso postmoderno almodovariano, sustentado en la intertextualidad, la hibridación de géneros, el diálogo inter artes, la relectura de imaginarios cinematográficos y pictóricos y, en gran medida, el juego persistente con la ilusión de lo metaficcional.