bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alleviation of nonlinear channel effects in long‐haul and high‐capacity optical transmission networks
Authors: Ali Farman , Habib Usman , Muhammad Fazal , Khan Yousaf , Armghan Ammar , Alenezi Fayadh , Abbas Ziaul Haq , Ali Asar , Qamar Muhammad Salman 
Published: November 2021

SummaryOptical transmission networks (OTxNs) provide a cost‐effective solution towards ultrahigh data intercontinental transmission. However, nonlinear effects such as four‐wave mixing (FWM) and cross‐phase modulation (XPM) are the major performance limiting factors for OTxNs. This paper proposes the use of differential quadrature phase shift keying (DQPSK) modulation format and uneven channel spacings for dispersion compensation and investigates the nonlinear mitigation performance for a 32 channels ultradense wavelength division multiplexing (UDWDM) with data rate of up to 10 Gbps per channel. In addition, this paper presents an analysis on power budget and power penalties with a cost benefit analysis (CBA) for the proposed framework. The transmission link of the proposed UDWDM model is analyzed in terms of bit error rate (BER) for various lengths of optical fiber in long‐haul transmission, launch power, nonlinear effective area, and nonlinear refractive index. The analytical model is developed for mitigation of nonlinearity for the modeled UDWDM long‐haul and ultrahigh‐capacity system, beyond 1200‐km path span. The simulation results show systems advantages of having narrower spectrum than on‐off‐keying (OOK) modulation, significant tolerance to nonlinearities and low cost, compared with current OTxNs with 2.8‐dB optical signal‐to‐noise ratio (OSNR) improvement and successful mitigation of nonlinearities for as high launch powers as +4 dBm for such long distance transmission in dispersive channel.
Aetiological classification and prognosis in patients with heart failure with preserved ejection fraction
Authors: Fayol Antoine , Wack Maxime , Livrozet Marine , Carves Jean‐Baptiste , Domengé Orianne , Vermersch Eva , Mirabel Mariana , Karras Alexandre , Le Guen Julien , Blanchard Anne , Azizi Michel , Amar Laurence , Bories Marie‐Cécile , Mousseaux Elie , Carette Claire , Puymirat Etienne , Hagège Albert , Jannot Anne‐Sophie , Hulot Jean‐Sébastien 
Published: November 2021

AbstractAimsHeart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with various causes that may influence prognosis.Methods and resultsWe extracted the electronic medical records for 2180 consecutive patients hospitalized between 2016 and 2019 for decompensated heart failure. Using a text mining algorithm looking for a left ventricular ejection fraction ≥50% and plasma brain natriuretic peptide level >100 pg/mL, we identified 928 HFpEF patients. We screened for a prevailing cause of HFpEF according to European guidelines and found that 418 (45.0%) patients had secondary HFpEF due to either myocardial (n = 125, 13.5%) or loading condition abnormalities (n = 293, 31.5%), while the remaining 510 (55.0%) patients had idiopathic HFpEF. We assessed the association between the causes of HFpEF and survival collected up to 31 December 2020 using Cox proportional hazards analysis. Even though patients with idiopathic HFpEF were older, frequently female, and had frequent co‐morbidities and a higher crude mortality rate compared with secondary HFpEF patients, their prognosis was similar after adjustment for age and sex. Unsupervised clustering analysis revealed three main phenogroups with different distribution of idiopathic vs. secondary HFpEF. The phenogroup with the highest proportion of idiopathic HFpEF (69%) had (i) an excess rate of non‐cardiac co‐morbidities including chronic obstructive pulmonary disease (31%) or obesity (41%) and (ii) a better prognosis compared with the two other phenogroups enriched with secondary HFpEF.ConclusionsAetiological classification provides clinical and prognostic information and may be useful to better decipher the clinical heterogeneity of HFpEF.
Understanding the Binding Properties of N‐heterocyclic Carbenes through BDE Matrix App
Authors: Morán‐González Lucía , Pedregal Jaime Rodríguez‐Guerra , Besora Maria , Maseras Feliu 
Published: November 2021

AbstractThe interaction of N‐heterocyclic carbene (NHC) ligands with transition metal centers is analyzed with a set of descriptors derived from the statistical treatment of density functional theory (DFT) computational results. These descriptors, labeled as hidden descriptors (HD), had been previously defined in our group and here are applied with the help of a user‐friendly web application developed for that purpose: BDE Matrix App. Five HDs are computed with little computational effort for each NHC under consideration. Expectations are confirmed in that the binding to the metal center is largely ruled by the first two descriptors, suitably associated to σ donation and π backdonation, and the approach leads to a straightforward comparison of their quantitative values. The study is extended beyond NHCs, and other neutral ligands, such as cyclopropenylidenes, phosphines, and amines are considered. The procedure is shown to be well suited to provide a unified framework for the comparison of these diverse ligands.
Effect of using a porous gas cooler on the performance of trans‐critical carbon dioxide refrigeration cycle
Authors: Tarawneh Mohammad 
Published: November 2021

AbstractUsing porous gas coolers is a novel method that can be used to enhance performance parameters in the trans‐critical carbon dioxide refrigeration cycle. The behavior of trans‐critical carbon dioxide and the effect of using porous gas coolers in refrigeration systems are researched in this experimental study. Cycle coefficient of performance, heat rejection rate, evaporator cooling capacity, evaporator cooling capacity enhancement factor, coefficient of performance enhancement factor, power consumption per ton of refrigeration, and pressure drop were investigated as functions of gas cooler outlet temperature, gas cooler porosity, gas cooler pressure ratio, and air ambient temperature. Porosities of 100% (empty gas cooler; no steel balls are used during this test), 48%, 40%, and 34% were considered. Experiments were conducted at 4°C evaporating temperature and 5°C superheat. Evaporator cooling capacity and evaporator cooling capacity enhancement factor are increased by about 103% and 35.4% when reducing gas cooler outlet temperature and porosity up to 36°C and 34%, respectively. Results of this study showed that cycle coefficient of performance, coefficient of performance enhancement factor, and gas cooler heat rejection rate can be increased up to 94.4%, 55.8%, and 85.5%, respectively when reducing gas cooler porosity and gas cooler outlet temperature up to 34% and 36°C. Increasing the gas‐cooler pressure ratio up to 1.341 and reducing gas cooler porosity up to 34% resulted in an increase of about 76.2% in the coefficient of performance. A decrease in power consumption per ton of refrigeration by about 43.9% is recorded when decreasing gas cooler inlet pressure and porosity up to 84 bars and 34%, respectively. Experiments revealed that a decrease in pressure drop of about 43.7% can be achieved by increasing gas cooler outlet temperature up to 52.1°C and keeping gas cooler porosity at 34%. The cycle coefficient of performance can be increased by decreasing air outside ambient temperature.
Predicted long‐term impact of COVID‐19 pandemic‐related care delays on cancer mortality in Canada
Authors: Malagón Talía , Yong Jean H. E. , Tope Parker , Miller Wilson H. , Franco Eduardo L. ,   McGill Task Force on the Impact of COVID‐19 on Cancer Control and Care
Published: November 2021

AbstractThe COVID‐19 pandemic has affected cancer care worldwide. This study aimed to estimate the long‐term impacts of cancer care disruptions on cancer mortality in Canada using a microsimulation model. The model simulates cancer incidence and survival using cancer incidence, stage at diagnosis and survival data from the Canadian Cancer Registry. We modeled reported declines in cancer diagnoses and treatments recorded in provincial administrative datasets in March 2020 to June 2021. Based on the literature, we assumed that diagnostic and treatment delays lead to a 6% higher rate of cancer death per 4‐week delay. After June 2021, we assessed scenarios where cancer treatment capacity returned to prepandemic levels, or to 10% higher or lower than prepandemic levels. Results are the median predictions of 10 stochastic simulations. The model predicts that cancer care disruptions during the COVID‐19 pandemic could lead to 21 247 (2.0%) more cancer deaths in Canada in 2020 to 2030, assuming treatment capacity is recovered to 2019 prepandemic levels in 2021. This represents 355 172 life years lost expected due to pandemic‐related diagnostic and treatment delays. The largest number of expected excess cancer deaths was predicted for breast, lung and colorectal cancers, and in the provinces of Ontario, Québec and British Columbia. Diagnostic and treatment capacity in 2021 onward highly influenced the number of cancer deaths over the next decade. Cancer care disruptions during the COVID‐19 pandemic could lead to significant life loss; however, most of these could be mitigated by increasing diagnostic and treatment capacity in the short‐term to address the service backlog.
Angle‐ply scaffold supports annulus fibrosus matrix expression and remodeling by mesenchymal stromal and annulus fibrosus cells
Authors: Borem Ryan , Madeline Allison , Theos Chris , Vela Ricardo , Garon Alex , Gill Sanjitpal , Mercuri Jeremy 
Published: November 2021

AbstractThe angle‐ply multilaminate structure of the annulus fibrosus is not reestablished following discectomy which leads to reherniation of the intervertebral disc (IVD). Biomimetic scaffolds developed to repair these defects should be evaluated for their ability to support tissue regeneration by endogenous and exogenous cells. Herein a collagen‐based, angle‐ply multilaminate patch designed to repair the outer annulus fibrosus was assessed for its ability to support mesenchymal stromal and annulus fibrosus cell viability, elongation, alignment, extracellular matrix gene expression, and scaffold remodeling. Results demonstrated that the cells remained viable, elongated, and aligned along the collagen fiber preferred direction of the scaffold, upregulated genes associated with annulus fibrosus matrix and produced collagen on the scaffold yielding biaxial mechanical properties that resembled native annulus fibrosus tissue. In conclusion, these scaffolds have demonstrated their potential to promote a living repair of defects in the annulus fibrosus and thus may be used to prevent recurrent IVD herniations.
The Influence of Conventional Treatment on Symptoms and Complaints in Patients With Chronic Postsurgical Hypoparathyroidism
Authors: Stamm Bettina , Blaschke Martina , Wilken Lara , Wilde Deborah , Heppner Christina , Leha Andreas , Herrmann‐Lingen Christoph , Siggelkow Heide 
Published: November 2021

ABSTRACTQuality of life (QoL) is impaired in patients with chronic hypoparathyroidism (HypoPT). With a recently developed specific patient questionnaire, the 28‐item Hypoparathyroid Patient Questionnaire (HPQ 28), we were able to demonstrate an effect of laboratory parameters on symptoms and complaints identified by scales and items of the HPQ 28. Here, we evaluated the effect of conventional treatment modalities on QoL using this specific questionnaire. In this cross‐sectional study, we included 49 HypoPT (41 female and 8 male) patients. Laboratory values of total serum calcium, magnesium, phosphate, calcium‐phosphate product (CPP), and 24‐hour urine for calcium and phosphate were analyzed. Patients completed the HPQ 28 questionnaire during the corresponding visit. Mean age was 57.3 ± 10.5 years and duration of disease 12.6 ± 9.8 years. Most patients (86%, n = 42) were treated with the active vitamin D analogs calcitriol, alfacalcidol, or dihydrotachysterol (DHT). The use of calcium and magnesium supplements influenced scales on HPQ 28 in a dose‐dependent manner. We detected a dose‐dependent increase on the HPQ 28 scales “depression and anxiety” and “pain and cramps,” and the item “numbness and tingling” related to calcitriol. This effect was independent of gender, age, underlying disease, kind of surgery, serum 25‐hydroxyvitamin D3, calcium, or phosphate values. This study presents the first data on specific symptoms of HypoPT patients dependent on different treatment modalities. Our data suggest that in part the reduced QoL in these patients might be caused by conventional treatment. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Child‐centered play therapy and adverse childhood experiences: A randomized controlled trial
Authors: Ray Dee C. , Burgin Elizabeth , Gutierrez Daniel , Ceballos Peggy , Lindo Natalya 
Published: November 2021

AbstractThere is a preponderance of evidence that adverse childhood experiences (ACEs) result in harmful physical, learning, social, emotional, and behavioral health outcomes during childhood, with far reaching effects lasting across the lifespan. The cumulative effect of childhood adversity and its relationship to childhood trauma represent an urgent call to action among stakeholders, yet treatment studies are rare. The purpose of this randomized controlled trial was to explore the impact of child‐centered play therapy (CCPT) among children with two or more ACEs on improvement of social and emotional assets and behavioral problems. Results of a repeated measures linear mixed model demonstrated statistically significant increases in social‐emotional competencies including empathy, social competence, and self‐regulation/responsibility and decreases in total behavior problems among children who participated in CCPT. Results of this study support the effectiveness of CCPT among children who have experienced ACEs and at risk for complex trauma.
Channel regulation through solvents for Cd‐MOFs based on p‐methoxyphenyl imidazole dicarboxylate: Synthesis, crystal structure, fluorescence, and explosive identification
Authors: Jiang Yuxuan , Dong Jianping , Li Ruixue , Sun Fugang , Wu Huilu 
Published: November 2021

AbstractUnder different solvent systems, the reaction of Cd(NO3)2·4H2O with 2‐p‐methoxyphenyl‐1H‐imidazole‐4,5‐dicarboxylic acid (p‐H3MOPhIDC) ligand produce two new Cd‐MOFs, [Cd(p‐HMOPhIDC)(C2H5OH)]n (1) and [Cd2(p‐HMOPhIDC)2(Py)(C2H5OH)]n (2). Structural analysis shows that although the two Cd‐MOFs have the same six‐coordinated distorted octahedron geometry of the Cd(II) centers and the similar framework structure, they have different coordinated polymerization unit symmetry and internal environment in the channels. Among them, the polymerization unit in the channel of Cd‐MOFs 1 is centrosymmetric, while the polymerization unit in the channel of Cd‐MOFs 2 is asymmetric. Compared with the free p‐H3MOPhIDC ligand, the fluorescence peaks of the two Cd‐MOFs in the solid‐state have undergone a slightly red shift and enhancement. This is due to the increased rigidity of the ligand after the coordination of the metal ions with the ligand, which reduces the energy loss of thermal vibration. The fluorescence enhancement of Cd‐MOFs 1 is greater than that of 2, which is related to the symmetry of the coordination polymerization units in the two Cd‐MOFs channels. In addition, Cd‐MOFs 2 can highly sensitive sense 2,4‐dinitrotoluen (DNP) and 2,4,6‐trinitrophenol (TNP) through luminescence quenching effect, whereas 1 cannot. This result is due to the difference in the environment within their channels.
Expression of SET domain bifurcated histone lysine methyltransferase 1 and its clinical prognostic significance in hepatocellular carcinoma
Authors: Wang Chunnian , Xia Zhaoxia , Li Zheng , Ye Fusang , Ji Shengqiang , Lu Changjiang , Zhang Huizhi 
Published: November 2021

AbstractBackgroundTo detect the expression of histone methyltransferase SETDB1 in hepatocellular carcinoma, and to analyze the relationship between SETDB1 expression and tumor size, microvascular invasion, pTNM stage, gender, age, tumor number, tumor differentiation, and other clinicopathological characteristics.MethodsImmunohistochemical method was used to detect the expression of SETDB1 proteins in liver cancer tissues and adjacent tissues of 100 cases. The qRT‐PCR method was used to detect the expression of SETDB1 mRNA in hepatocellular carcinoma and adjacent tissues of 64 cases.ResultsThe expression of SETDB1 protein and mRNA in hepatocellular carcinoma was higher than that of adjacent normal liver tissue (p < 0.05). High protein expression of SETDB1 was associated with tumor size, MVI presence, and pTNM stage (p < 0.05). Univariate analysis revealed that the tumor size, tumor differentiation, MVI grade, and pTNM stage were correlated with DFS, while tumor size, MVI grade, pTNM stage, and SETDB1 protein expression were correlated with OS. Multivariate analysis showed that the combination of MVI grade and pTNM stage has statistical significance in predicting prognosis, while SETDB1 protein expression was not significant prognosis factor.ConclusionsSETDB1 has a certain role in HCC progression and may act as a prognostic predictor concerning the survival of HCC patients.
Racial and ethnic differences in emotion regulation: A systematic review
Authors: Weiss Nicole H. , Thomas Emmanuel D. , Schick Melissa R. , Reyes Miranda E. , Contractor Ateka A. 
Published: November 2021

AbstractObjectiveEmotion regulation is a transdiagnostic mechanism with relevance to the etiology, maintenance, and treatment of a wide range of clinically relevant outcomes. This study applied systematic review methods to summarize the existing literature examining racial and ethnic differences in emotion regulation.MethodsWe systematically searched four electronic databases (PsycINFO, Embase, MEDLINE, and CINAHL Plus) using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines.ResultsOf the initial 1253 articles, 25 met the inclusion criteria. Findings for emotion regulation strategies generally provide evidence for racial/ethnic differences (71% of reviewed studies), with ethnoracial minorities largely exhibiting greater use of emotion regulation strategies. Whereas the results for emotion regulation potential were slightly more mixed (63% of reviewed studies found racial/ethnic differences), ethnoracial minorities were also largely found to report lower emotion regulation potential.ConclusionThis review advances the literature by providing additional support for racial and ethnic differences in emotion regulation.
Morphological characterization and distribution of antennal sensilla of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) using scanning electron microscopy
Authors: Abalavadi Thammaiah Rani , Pathour Shashank , Meshram Naresh , Kammar Vasudev , Majumder Sujan , Srivastava Chitra , Pandey Koshlendra , Singh Jagdish 
Published: November 2021

AbstractHelicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) is a serious polyphagous pest of various field and horticultural crops. A complete knowledge on the morphological features of antennal sensory structures is essential for efficient semiochemical‐based control methods. The external structure and distribution of antennal sensilla in male and female adults of H. armigera were investigated using scanning electron microscopy. Eight distinct morphological types of sensilla were identified in both sexes: sensilla trichodea, sensilla basiconica, sensilla auricillica, sensilla coeloconica (multiporous), sensilla chaetica (uniporous), sensilla styloconica, sensilla squamiformia, and Böhm sensilla (aporous) in varying numbers and distribution along the length of the antennae. Of these sensilla, the most widespread are sensilla trichodea and sensilla basiconica on the antennae of both sexes. Female antennae have comparatively greater number of sensilla trichodea than male antennae. Among eight types of sensilla, sensilla basiconica, auricillica, styloconica type II, squamiformia, and Böhm sensilla were identified and reported for the first time in H. armigera. Sexual dimorphism in H. armigera was mainly detected as the variations in sensilla shape, numbers, and distribution of each type of sensilla. The sexual difference was observed in the numbers of sensilla coeloconica, chaetica, styloconica, and squamiformia per flagellomere. The possible functions of these sensilla were discussed in view of previously reported lepidopteran insects. The findings provide fundamental information on the morphology and distribution of antennal sensory structures in H. armigera. It would be useful for further detailed studies on physiological and behavioral function of each sensillum type and helpful for formulating related pest control methods.
Evolutionary analysis of rotavirus G1P[8] strains from Chennai, South India
Authors: Selvarajan Sribal , Reju Sudhabharathi , Gopalakrishnan Krithika , Padmanabhan Ramachandran , Srikanth Padma 
Published: November 2021

AbstractRotaviruses by virtue of its segmented genome generate numerous genotypes. G1P[8] is the most common genotype reported globally. We intend to identify the evolutionary differences among G1P[8] strains from the study with vaccine strains. Stool samples collected from children <5 years were screened for rotavirus antigen by enzyme linked immunosorbent assay. The samples that tested positive for rotavirus were subjected to VP7 and VP4 semi‐nested RT‐PCR. Sanger sequencing was performed in randomly chosen VP7 and VP4 rotavirus strains. Phylogenetic analysis showed less homology between study strains and vaccine strains and they were placed in different lineages. The VP7 and VP4 proteins of rotavirus were analyzed by two different platforms to identify the amino acid substitutions in the epitope regions. Nine amino acid substitutions with respect to Rotarix®, RotaTeq® and Rotasiil®—V66A, A/T68S, Q72R, N94S, D100E, T113I, S123N, M217T, and I281T were observed in VP7. There were five amino acid substitutions—S145G, N/D195G, N113D, N/I78T, E150D in VP4 (VP8 portion) with respect to Rotarix® and RotaTeq® vaccine strains. M217T substitution in VP7 (epitope 7‐2) and N113D, D195G substitution in VP4 (epitope 8‐3, 8‐1) confer changes in polarity/electrical charge with respect to vaccine strains, thus indicating the need for continued surveillance.
Holomorphic function spaces on the Hartogs triangle
Authors: Monguzzi Alessandro 
Published: November 2021

AbstractThe definition of classical holomorphic function spaces such as the Hardy space or the Dirichlet space on the Hartogs triangle is not canonical. In this paper we introduce a natural family of holomorphic function spaces on the Hartogs triangle which includes some weighted Bergman spaces, a candidate Hardy space and a candidate Dirichlet space. For the weighted Bergman spaces and the Hardy space we study the mapping properties of Bergman and Szegő projection respectively, whereas for the Dirichlet space we prove it is isometric to the Dirichlet space on the bidisc.