bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avoiding the ‘survivorship abyss’: Qualitative insights from 15‐year prostate cancer survivors
Authors: Mazariego Carolyn G. , Laidsaar‐Powell Rebekah , Smith David P. , Juraskova Ilona 
Published: May 2021

AbstractObjectiveAs many men diagnosed with prostate cancer (PC) are now living well beyond diagnosis and treatment, these survival gains necessitate improved understanding of long‐term survivorship experiences. This is the first qualitative study that aimed to provide insights into PC survivors' adjustment to diagnosis and any persisting or emerging cancer/treatment‐related issues over 15+ years.MethodsSemi‐structured interviews were conducted with 37 men purposively sampled from the 15‐year follow‐up phase of a population‐wide cohort study, the New South Wales Prostate Cancer Care and Outcomes Study (PCOS). Interview data were transcribed and thematically analysed applying a framework methodology.ResultsThe majority of participating men (88.6%) had been diagnosed with localised disease and were treated with radical prostatectomy as primary treatment (54.1%). Four main interconnecting themes relating to men's long‐term survivorship experience with PC were identified: (1) Survivorship reflections, (2) interactions with the healthcare system, (3) personal and social relationships and (4) dominant coping strategies. Many men reported gaps along the continuum of care and a feeling of abandonment across their long‐term survivorship, encompassed by a perceived lack of psychosocial and informational support for persisting treatment side‐effects, especially sexual dysfunction. Receiving adequate survivorship care and trusting patient–clinician relationships appeared to be associated with greater resilience and positivity in the men's acceptance of cancer‐related long‐term challenges and personal limitations.ConclusionsLong‐term PC survivors continue to experience lasting treatment impacts, with many men reporting unmet needs and a lack of continuity of multidisciplinary care. Implementation of coordinated and tailored survivorship care and shared care pathways with multidisciplinary practitioners will facilitate men's improved engagement and timely access to supportive care interventions, helping to avoid the ‘survivorship abyss’.
Evaluating the impact of the Patient Preference Assessment Tool on clinicians' recommendations for phase I oncology clinical trials
Authors: Hianik Rachel S. , Owonikoko Taofeek , Switchenko Jeffrey , Dixon Margie D. , Shaib Walid L. , Pentz Rebecca D. 
Published: May 2021

AbstractObjectiveMany groups recommend assessment of patient preferences particularly for patients with advanced, incurable cancer. We, therefore, developed the Patient Preference Assessment Tool (PPAT) to ascertain patient preferences in order to inform clinician recommendations and improve shared decision‐making. The aim of this study is to assess the PPAT's impact on clinicians' strength of recommendations for phase I oncology clinical trials.MethodsClinicians recorded the strength of their recommendation on a Likert scale before viewing the patient's PPAT. After viewing the PPAT, the clinician discussed the clinical trial with the patient and then recorded the strength of recommendation again. If there was a change, the clinician noted the reason for the change: clinical findings or patient preference. Clinicians were interviewed about the acceptability of the tool. Our threshold for determining if a change in recommendation due to the PPAT was significant was 20%, given the multiple factors influencing a clinician's recommendation. We also noted the type of phase I conversation observed based on classifications defined in prior work—priming, treatment‐options, trial logistics, consent.ResultsN = 29. The strength of the clinicians' recommendations changed due to patient preferences in 7 of 29 (24%) of the conversations. The seven changes due to preferences were all in the 23 treatment‐options conversations, for an impact rate of 30% in this type of conversation. 82% of clinicians found the PPAT useful.ConclusionThe PPAT was impactful in an academic setting, exceeding our 20% impact threshold. This tool helps achieve the important goal of incorporating patient preferences into shared decision‐making about clinical trials.
Moving pictures: Reassessing docking experiments with a dynamic view of protein interfaces
Authors: Prévost Chantal , Sacquin‐Mora Sophie 
Published: May 2021

AbstractThe modeling of protein assemblies at the atomic level remains a central issue in structural biology, as protein interactions play a key role in numerous cellular processes. This problem is traditionally addressed using docking tools, where the quality of the models is based on their similarity to a single reference experimental structure. However, using a static reference does not take into account the dynamic quality of the protein interface. Here, we used all‐atom classical Molecular Dynamics simulations to investigate the stability of the reference interface for three complexes that previously served as targets in the CAPRI competition. For each one of these targets, we also ran MD simulations for ten models that are distributed over the High, Medium and Acceptable accuracy categories. To assess the quality of these models from a dynamic perspective, we set up new criteria which take into account the stability of the reference experimental protein interface. We show that, when the protein interfaces are allowed to evolve along time, the original ranking based on the static CAPRI criteria no longer holds as over 50% of the docking models undergo a category change (which can be either toward a better or a lower accuracy group) when reassessing their quality using dynamic information.
Double‐valence photoionization of SUVA134a molecule (CFH2CF3)
Authors: Morcelle Viviane , Medina Aline , Ribeiro Leonardo C. , Prazeres Italo , Marinho Ricardo R. T. , Arruda Manuela S. , Mendes Luis A. V. , Santos Mabele de Jesus , Santos Antonio Carlos Fontes dos 
Published: May 2021

RationaleIn this work we investigate the single‐photon double ionization of the SUVA 134a (1,1,1,2‐tetrafluoroethane) molecule in the energy range from 21.21 to 320 eV. Our experimental data are supported by Thomas’ and Samson's models. It is shown that the double photoionization of the SUVA 134a can be expressed as a sum of the so‐called shake‐off (SO) and the knockout (KO) processes.MethodsThe experiments were executed at the TGM beamline at Laboratório Nacional de Luz Síncrotron in Campinas, Brazil. The source of EUV and X‐ray radiation was a bending magnet that enabled us to work in the photon energy range of 21.21 to 320 eV. The spectrometer was devised to collect 100% of the ions with kinetic energies up to 30 eV. The photoelectron‐photoion (PEPICO) and photoelectron‐photoion‐photoion (PE2PICO) coincidence techniques were used in the present work.ResultsThe ratio of double‐to‐total photoionization as a function of the photon energy for the SUVA molecule exhibits remarkably similar behavior with other atomic and molecular systems. SO depends on large excess energy above the ionization threshold, enabling the photoelectron to leave the interaction region rather speedily to yield a sudden change in the Coulomb field that the shaken electron feels. The measured asymptotic SO probability is PSO (∞) = 0.09.ConclusionsThe present analysis shows that the separation of SO and KO processes relies on the experimental evidence that there is no significant interference between SO and KO. The analysis also shows that the separate formulation of KO and SO presents a factual portrayal of double photoionization. Despite having 50 electrons, SUVA has lower double‐to‐total photoionization fraction (9%) in comparison, for instance, to argon atoms (~20%), which has 18 electrons. This lower e‐e correlation could be attributed to its larger volume, that is, lower electron density.
Pulmonary lymphomatoid granulomatosis: An uncommon disease but not to be forgotten—a single centre experience
Authors: Balakrishnan Pradeep , Ing Matthew , Househ Zaid , Raguparan Ajantha 
Published: May 2021

AbstractPulmonary lymphomatoid granulomatosis (PLG) is a rare multisystem Epstein–Barr virus (EBV)‐associated lymphoproliferative disorder. Exact incidence is unknown and, with its variable clinical presentation, making an accurate diagnosis of PLG can be difficult. We present two distinct cases at our tertiary centre that underline PLG's non‐specific clinical presentations. This resulted in the failure of recognizing PLG early with consequently progressive fatal outcomes. The rationale is to enlighten us concisely the knowledge surrounding PLG and consider it as a potential differential diagnosis, particularly in those immunosuppressed patients with radiological evidence of worsening pulmonary infiltrates not responding to customary treatment for common diagnoses. Having a high degree of suspicion for PLG in the right setting and pursuing lung biopsy early if appropriate for histopathology examination would be justified. This is essential to correctly diagnose PLG up‐front and subsequently utilize best management approach for a better survival and mortality risk outlook.
Fully distributed observer‐based protocols for bipartite consensus of directed nonlinear multi‐agent systems: A proportional‐integral‐gain perspective
Authors: Nan Xiaoya , Lv Yuezu , Duan Zhisheng 
Published: May 2021

AbstractThis paper presents a novel perspective on fully distributed adaptive protocol design for bipartite consensus under directed communication graphs. It is revealed that the fully distributed protocol is indeed a PI‐gain design approach. Based on such PI‐gain method, fully distributed observer‐based protocols are proposed to solve the consensus problem of nonlinear multi‐agent systems over directed cooperative‐antagonistic networks, where the neural network approximation is introduced to tackle the unknown nonlinearity. Fully distributed continuous protocols are further presented by modifying the sign function with a decaying variable, which takes the advantage of avoiding chattering problem. Theoretical analysis and numerical simulations are given to support our main results.
Hetero Metal‐Organic Hybrids as Highly Active Peroxidase Mimics for Biosensing Application
Authors: Alam Naveed , Sreeramareddygari Muralikrishna , Somasundrum Mithran , Jayaramulu Kolleboyina , Surareungchai Werasak 
Published: May 2021

AbstractWe have described a facile methodology for producing a series of novel homo and hetero metal organic hybrids (OGH) using Fe, Cu and trithiocyanuric acid (TTCA), and have demonstrated that the presence of both metals together considerably enhances the peroxidase activity of the hybrids, relative to either metal on its own. Characterization by XRD, FTIR, Raman spectroscopy and XPS indicated that the hetero materials consisted of predominantly Fe2+ and Cu+ and that bonding to Cu was largely through the N and S of the TTCA, while bonding to Fe was largely through Fe−S bonds. The Fe : Cu content of the hetero materials was varied systematically in the approximate ratios 1 : 1, 1 : 2 and 2 : 1, as confirmed by elemental analysis. Peroxidase activity was examined using 3,3′,5,5′‐tetramethylbenzidine (TMB), dopamine (DA) and luminol as co‐substrates. The 1 : 1 Fe : Cu catalyst was found to have the highest activity. Kinetic analysis indicated that TMB and dopamine oxidation proceeded by a sequential Bi−Bi mechanism. This mechanism utilized dissolved O2 and generated .OH radicals, as indicated by experiments with N2 purging and a hydroxyl trapping reagent. Based on KM values, substrate affinities were in the order TMB>H2O2>dopamine. Chemiluminescence in the presence of luminol and glucose oxidase‐generated H2O2 was used to calibrate glucose in the range 2–10 mM. The hetero metal hybrid catalyst was stable for two months when stored at room temperature.
Reactive Extrusion‐Processed Shape‐Memory Food Packaging Films Made from Native and Carboxymethylated Plantain Flour/Polystyrene Blends
Authors: Herniou‐‐Julien Clémence , Gutiérrez Tomy J. 
Published: May 2021

AbstractSeveral alternatives have been proposed to improve the properties of starch‐based films. However, single step processing and modification procedures such as reactive extrusion (REx) have been little studied in conjunction with carbohydrate polymers. Films were prepared from native and carboxymethylated plantain (Musa ssp., group AAB, sub‐group clone Harton) flour/polystyrene (PS) blends, with glycerol as a plasticizer, by REx using a twin‐screw extruder with chromium octanoate (Cr(Oct)3) as a catalyst (Cat), followed by thermo‐molding. The structural, physicochemical, thermal, surface, mechanical (shape memory) and antimicrobial properties relevant to the potential use of the films in food packaging applications, were then exhaustively characterized. The developed films could be used as shape materials due to their mechanical properties, which featured elastic, creep, and plastic zones, as long as the following mechanical thresholds are not reached: 1.00% strain and 1.14 MPa stress (for the film with the best characteristics). The results of the TGA, mechanical properties tests and antimicrobial activity assay suggest that Maillard reactions can occur simultaneously with the cross‐linking reactions generated by the Cat between the natural and synthetic polymers. The films made with the carboxymethylated flour were less hydrophilic than those prepared using the native flour due to the establishment of a higher dipole moment.
Redox of Viologen for Powering and Coloring
Authors: Sagara Takamasa , Tahara Hironobu 
Published: May 2021

AbstractViologen is among the most attractive and easiest‐to‐use organic redox active group in many functional molecular assemblies. It plays crucial roles as an electron transfer mediator in the artificial photo‐energy conversion systems and electron‐transfer protein assemblies and as a building block of supramolecules. Its features include electrochemically reversible redox activity and stability. Strong blue color and tendency to dimerization of the one‐electron reduced form, viologen mono‐radical mono‐cation, are remarkable. In this Account, we describe the use of viologen to give a powered movement of small molecules and motion of millimetre‐sized macroscopic soft‐matters and the use of viologen ionic liquid as electrochromic materials. Attractivities of the use of viologen units for powering and coloring are demonstrated and discussed. In particular, we highlight driving of mechanical movements by π–π stacking dimerization, incorporation in a hydrogel to attain highly deformable material, induction of 2D phase transformation, and sharp color change of very thin ionic liquid layer in a compartment‐less electrochromic display.
Managingmarketing–sales–servicerelationship conflict in aB2Bmultinational firm
Authors: Enyinda Chris I. , Enyinda Ifeoma E. , Mbah Chris H. , Ogbuehi Alphonso O. 
Published: May 2021

ABSTRACTManaging conflict in marketing–sales–customer service relationship is pivotal for seamless, end‐to‐end customer experience, satisfaction of customer changing needs, and business performance. Research examining conflict management in marketing–sales–service cross‐functional relationships is lacking in B2B multinational firms, and particularly in the electronics industry. This article draws on social exchange theory (SET) to posit that conflict management in a B2B electronics firm marketing–sales–service relationship can be successful if trust, commitment, and reciprocity exist. This article examines factors influencing conflict in the team relationship in the focal firm and how to manage them. Data were collected from the departmental managers and were then analyzed with the analytic hierarchy process (AHP)‐based multicriteria decision making (MCDM) framework. The findings reveal that the most important factor influencing conflict is task, followed by communication, inter alia. The overall best strategy in managing conflict is collaboration/integration, followed by confrontation. Our research enhances the understanding of conflict factors influencing the focal B2B interdepartmental relationships and the appropriate management strategies. Effectively managing the interdepartmental conflicts can lead to customer satisfaction and improved business performance.
Compound essential oils relieve oxidative stress caused by PM2.5 exposure by inhibiting autophagy through the AMPK/mTOR pathway
Authors: Ren Fei , Xu Xin , Xu Jingbin , Mei Yuhui , Zhang Jiahua , Wang Xuguang , Li Fasheng 
Published: May 2021

AbstractFine particulate matter (PM2.5) potentially damages the respiratory system and causes respiratory diseases. Compound essential oils (CEOs) have been shown to alleviate the damage to the lung and macrophages caused by PM2.5. However, the effect of PM2.5 exposure on the brain has rarely been investigated. When oxidative stress occurs in the brain, it readily causes neurological diseases. Autophagy is intimately involved in many physiological processes, especially processes important for the brain. Blocked or excessive autophagy causes a series of brain diseases, such as cerebral ischemia and stroke. This study investigated whether CEOs regulate excessive autophagy and reduce the oxidative stress caused by PM2.5 in the brain and BV2 microglial cells. PM2.5 increased the levels of ROS, Nox2, NF‐κB and MDA while decreasing superoxide dismutase and HO‐1 levels, which led to oxidative stress in the brain. The increased LC3 level and decreased P62 level suggested that PM2.5 exposure increased the level of autophagy. After exposure to PM2.5, the levels of 5′‐adenosine monophosphate‐activated protein kinase (AMPK) increased, while the levels of mammalian target of rapamycin (mTOR) decreased, suggesting that PM2.5 might induce autophagy by activating the AMPK/mTOR pathway. In addition, CEOs alleviated oxidative stress and autophagy induced by PM2.5. Therefore, we concluded that CEOs reduce oxidative stress induced by PM2.5 exposure by inhibiting autophagy via the AMPK/mTOR signaling pathway, and these findings provide new opportunities for the prevention of PM2.5‐induced brain diseases.
Bovine semen sexing: Sperm membrane proteomics as candidates for immunological selection of X‐ and Y‐chromosome‐bearing sperm
Authors: Quelhas Joana , Santiago Joana , Matos Bárbara , Rocha António , Lopes Graça , Fardilha Margarida 
Published: May 2021

AbstractThe use of sexed semen in dairy and beef farms ensures the production of animals of the desired sex, resulting in a reduction of costs and an improvement of environmental sustainability. Several methods have been developed over the years, but most of them were abandoned due to their limited efficacy. Currently, the only commercially available method for the separation of X‐ and Y‐chromosome‐bearing sperm is fluorescence‐activated cell sorting. However, this technique is expensive and has limited usefulness for the industry, considering that it cannot produce doses of sexed semen with the desired number of sperm for artificial insemination. Immunological methods have emerged as an attractive alternative to flow cytometry and proteomic knowledge of X‐ and Y‐sperm could be useful to the development of a new method. In this review, we identify the main applications of sexed semen, describe the existing methods and highlight future research opportunities in the field. We consider that immunological methods, based on sperm cell's surface proteins differentially expressed between X‐ and Y‐sperm, could be an interesting and promising approach to semen sexing.
A suspected non‐allergic anaphylactic reaction to intravenous administration of atracurium in a dog
Authors: Testa Barbara , Pawson Pat , Bell Andrew 
Published: May 2021

AbstractHypersensitivity reactions are rare events but have the potential to be life‐threatening. They are relatively more common during general anaesthesia. This is potentially due to multiple drugs being administered concurrently. An 8‐year‐old, female neutered Labrador Retriever with bilateral cataracts was anaesthetised for right phacoemulsification. Soon after atracurium administration, the patient's heart rate (HR) increased, alongside decreases in arterial blood pressure and end tidal carbon dioxide (ETCO2). The dog was treated with clorphenamine and ephedrine intravenously (IV), while receiving a crystalloid fluids bolus. After 20 minutes both HR and blood pressure normalised, and the remainder of anaesthesia and recovery were uneventful. We suspected a non‐allergic anaphylactic reaction to atracurium.
Geophysics conquering new territories: The rise of “agrogeophysics”
Authors: Garré Sarah , Hyndman David , Mary Benjamin , Werban Ulrike 
Published: May 2021

AbstractAgriculture is facing immense challenges. We have to produce enough food while safe‐guarding the environment for future generations. This results in the need to use less water and fertilizer, and to harness soil quality. Key to achieving this goal is improving the understanding of processes and interactions governing the soil–plant–atmosphere continuum of agricultural ecosystems. Geophysical tools have great potential to better characterize and quantify these processes noninvasively from the plot to landscape scale. Nevertheless, a number of challenges remain for geophysical results to be better exploited by different scientific communities and by decision‐makers. In this special section, we explore ongoing research in the relatively new field of agrogeophysics, and we provide an overview of potential applications and highlight future research needs.
Role of air scouring in anaerobic/anoxic tanks providing nitrogen removal by mainstream anammox conversion in a hybrid biofilm/suspended growth full‐scale WWTP in China
Authors: Yuan Quan , He Beiping , Qian Liang , Littleton Helen , Daigger Glen T. , van Loosdrecht Mark , Wells George F. , Wang Kaijun , Cai Hulin 
Published: May 2021

AbstractA full‐scale wastewater treatment plant in China experienced unintentional anammox bacterial enrichment on biofilm carriers placed in the anaerobic and anoxic zones of an anaerobic/anoxic/oxic process under ambient temperatures and without bioaugmentation. Here, we show that microaerophilic conditions resulting from air scouring needed for biofilm carrier suspension in the anaerobic/anoxic zones can support a robust nitritation/anammox process. Results from an in situ on/off air scouring test showed that air scouring strongly induced both ammonia and total inorganic nitrogen removal in the anaerobic/anoxic zones. Ammonium concentration in the anaerobic and anoxic tanks remained constant or even slightly increased when air scouring was off, indicating that air scouring made a noticeable difference in nitrogen profiles in the anaerobic/anoxic zones. Various batch tests further indicated that partial denitrification is not likely to generate nitrite for anammox bacteria. Robust nitritation, and anammox on the carriers, can occur at low dissolved oxygen conditions, as measured in the full‐scale facility. The observations show that mainstream deammonification without sidestream bioaugmentation at moderate temperature is feasible and further optimization by a more dedicated design can result in improved nitrogen removal in cases when chemical oxygen demand is limited in mainstream wastewater treatment.Practitioner points

Microaerophilic conditions in a full‐scale IFAS reactor caused mainstream anammox in moderate temperate area.
Robust nitritation, and anammox on the carriers, can occur at low dissolved oxygen conditions in anaerobic/anoxic tanks with air scouring.
Anammox can function well with conventional nitrification and denitrification process at mainstream conditions for stable nitrogen removal.