bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘My Contributions Made a Significant Difference’: Young Carers’ Reflections on Their Participation in Social Work Admissions
Authors: Newman Andrea , Carey Bridgit , Kinney Malcolm 
Published: September 2021

Abstract
Whilst the participation of service users and carers (SUCs) in Social Work admissions (SWAs) has significantly developed over the past decades, concerns have been raised about the tokenistic nature of SUC involvement (Barnes, D., Carpenter, J. and Bailey, D. (2000) ‘Partnerships with service users in interprofessinal education for community mental health: A case study’, Journal of Interprofessional Care, 14(2), pp. 189–200) particularly in relation to young people (YP). Liverpool John Moores University (LJMU) in partnership with Barnardo’s Action with Young Carers Liverpool have (BAWYC) worked to develop meaningful participation for YP in SWA. In this article, we discuss our approach to YPs’ participation, exploring their experiences of involvement. Using a co-production approach, drawing on participatory action research methodology, we utilise in-depth interviews from a purposive sample of young carers (YCs) to ask questions about the nature of YPs’ participation including: How meaningful they consider their involvement; what are the outcomes and benefits and what are the continuing barriers? Adopting a reflective thematic analysis, research findings indicate that YCs feel valued and respected in their SWA role, and surprised at the level of involvement and decision making ascribed to them. They report personal development and feelings of self-worth and increased confidence, helping them to consider their own futures in a more aspirational way.
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Authors: Salman Mootaz M , Kitchen Philip , Halsey Andrea , Wang Marie Xun , Törnroth-Horsefield Susanna , Conner Alex C , Badaut Jerome , Iliff Jeffrey J , Bill Roslyn M 
Published: September 2021

AbstractAquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at the glia limitans, where it mediates water exchange across the blood–spinal cord and blood–brain barriers (BSCB/BBB), and controls cell volume, extracellular space volume, and astrocyte migration. Perivascular enrichment of AQP4 at the BSCB/BBB suggests a role in glymphatic function. Recently, we have demonstrated that AQP4 localization is also dynamically regulated at the subcellular level, affecting membrane water permeability. Ageing, cerebrovascular disease, traumatic CNS injury, and sleep disruption are established and emerging risk factors in developing neurodegeneration, and in animal models of each, impairment of glymphatic function is associated with changes in perivascular AQP4 localization. CNS oedema is caused by passive water influx through AQP4 in response to osmotic imbalances. We have demonstrated that reducing dynamic relocalization of AQP4 to the BSCB/BBB reduces CNS oedema and accelerates functional recovery in rodent models. Given the difficulties in developing pore-blocking AQP4 inhibitors, targeting AQP4 subcellular localization opens up new treatment avenues for CNS oedema, neurovascular and neurodegenerative diseases, and provides a framework to address fundamental questions about water homeostasis in health and disease.
Inaccurate cortical tracking of speech in adults with impaired speech perception in noise
Authors: Vander Ghinst Marc , Bourguignon Mathieu , Wens Vincent , Naeije Gilles , Ducène Cecile , Niesen Maxime , Hassid Sergio , Choufani Georges , Goldman Serge , De Tiège Xavier 
Published: September 2021

Abstract
Impaired speech perception in noise despite normal peripheral auditory function is a common problem in young adults. Despite a growing body of research, the pathophysiology of this impairment remains unknown. This magnetoencephalography study characterizes the cortical tracking of speech in a multi-talker background in a group of highly selected adult subjects with impaired speech perception in noise without peripheral auditory dysfunction. Magnetoencephalographic signals were recorded from 13 subjects with impaired speech perception in noise (six females, mean age: 30 years) and matched healthy subjects while they were listening to 5 different recordings of stories merged with a multi-talker background at different signal to noise ratios (No Noise, +10, +5, 0 and −5 dB). The cortical tracking of speech was quantified with coherence between magnetoencephalographic signals and the temporal envelope of (i) the global auditory scene (i.e. the attended speech stream and the multi-talker background noise), (ii) the attended speech stream only and (iii) the multi-talker background noise. Functional connectivity was then estimated between brain areas showing altered cortical tracking of speech in noise in subjects with impaired speech perception in noise and the rest of the brain. All participants demonstrated a selective cortical representation of the attended speech stream in noisy conditions, but subjects with impaired speech perception in noise displayed reduced cortical tracking of speech at the syllable rate (i.e. 4–8 Hz) in all noisy conditions. Increased functional connectivity was observed in subjects with impaired speech perception in noise in Noiseless and speech in noise conditions between supratemporal auditory cortices and left-dominant brain areas involved in semantic and attention processes. The difficulty to understand speech in a multi-talker background in subjects with impaired speech perception in noise appears to be related to an inaccurate auditory cortex tracking of speech at the syllable rate. The increased functional connectivity between supratemporal auditory cortices and language/attention-related neocortical areas probably aims at supporting speech perception and subsequent recognition in adverse auditory scenes. Overall, this study argues for a central origin of impaired speech perception in noise in the absence of any peripheral auditory dysfunction.
Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethality
Authors: Sargent Dorian , Cunningham Lindsey A , Dues Dylan J , Ma Yue , Kordich Jennifer J , Mercado Gabriela , Brundin Patrik , Cowell Rita M , Moore Darren J 
Published: September 2021

Abstract
Neurodegenerative diseases are characterized by the selective degeneration of neuronal populations in different brain regions and frequently the formation of distinct protein aggregates that often overlap between diseases. While the causes of many sporadic neurodegenerative diseases are unclear, genes associated with familial or sporadic forms of disease and the underlying cellular pathways involved tend to support common disease mechanisms. Underscoring this concept, mutations in the Vacuolar Protein Sorting 35 Orthologue (VPS35) gene have been identified to cause late-onset, autosomal dominant familial Parkinson’s disease, whereas reduced VPS35 protein levels are reported in vulnerable brain regions of subjects with Alzheimer’s disease, neurodegenerative tauopathies such as progressive supranuclear palsy and Pick’s disease, and amyotrophic lateral sclerosis. Therefore, VPS35 is commonly implicated in many neurodegenerative diseases. VPS35 plays a critical role in the retromer complex that mediates the retrieval and recycling of transmembrane protein cargo from endosomes to the trans-Golgi network or plasma membrane. VPS35 and retromer function are highly conserved in eukaryotic cells, with the homozygous deletion of VPS35 inducing early embryonic lethality in mice that has hindered an understanding of its role in the brain. Here, we develop conditional knockout mice with the selective deletion of VPS35 in neurons to better elucidate its role in neuronal viability and its connection to neurodegenerative diseases. Surprisingly, the pan-neuronal deletion of VPS35 induces a progressive and rapid disease with motor deficits and early post-natal lethality. Underlying this neurological phenotype is the relatively selective and robust degeneration of motor neurons in the spinal cord. Neuronal loss is accompanied and preceded by the formation of p62-positive protein inclusions and robust reactive astrogliosis. Our study reveals a critical yet unappreciated role for VPS35 function in the normal maintenance and survival of motor neurons during post-natal development that has important implications for neurodegenerative diseases, particularly amyotrophic lateral sclerosis.
Assessing the Longitudinal Relationship between Theta-Gamma Coupling and Working Memory Performance in Older Adults
Authors: Brooks Heather , Mirjalili Mina , Wang Wei , Kumar Sanjeev , Goodman Michelle S , Zomorrodi Reza , Blumberger Daniel M , Bowie Christopher R , Daskalakis Zafiris J , Fischer Corinne E , Flint Alastair J , Herrmann Nathan , Lanctôt Krista L , Mah Linda , Mulsant Benoit H , Pollock Bruce G , Voineskos Aristotle N , Rajji Tarek K 
Published: September 2021

Abstract
Theta-gamma coupling (TGC) is a neurophysiologic mechanism that supports working memory (WM). TGC is associated with N-back performance, a WM task. Similar to TGC, theta and alpha event-related synchronization (ERS) and desynchronization (ERD) are also associated with WM. Few studies have examined the longitudinal relationship between WM performance and TGC, ERS, or ERD. This study aimed to determine if changes in WM performance are associated with changes in TGC (primary aim), as well as theta and alpha ERS or ERD over 6 to 12 weeks. Participants included 62 individuals aged 60 and older with no neuropsychiatric conditions or with remitted Major Depressive Disorder (MDD) and no cognitive disorders. TGC, ERS, and ERD were assessed using electroencephalography (EEG) during the N-back task (3-back condition). There was an association between changes in 3-back performance and changes in TGC, alpha ERD and ERS, and theta ERS in the control group. In contrast, there was only a significant association between changes in 3-back performance and changes in TGC in the subgroup with remitted MDD. Our results suggest that the relationship between WM performance and TGC is stable over time, while this is not the case for changes in theta and alpha ERS and ERD.
Temporal Alterations to Central Auditory Processing without Synaptopathy after Lifetime Exposure to Environmental Noise
Authors: Occelli Florian , Hasselmann Florian , Bourien Jérôme , Puel Jean-Luc , Desvignes Nathalie , Wiszniowski Bernadette , Edeline Jean-Marc , Gourévitch Boris 
Published: September 2021

Abstract
People are increasingly exposed to environmental noise through the cumulation of occupational and recreational activities, which is considered harmless to the auditory system, if the sound intensity remains &lt;80 dB. However, recent evidence of noise-induced peripheral synaptic damage and central reorganizations in the auditory cortex, despite normal audiometry results, has cast doubt on the innocuousness of lifetime exposure to environmental noise. We addressed this issue by exposing adult rats to realistic and nontraumatic environmental noise, within the daily permissible noise exposure limit for humans (80 dB sound pressure level, 8 h/day) for between 3 and 18 months. We found that temporary hearing loss could be detected after 6 months of daily exposure, without leading to permanent hearing loss or to missing synaptic ribbons in cochlear hair cells. The degraded temporal representation of sounds in the auditory cortex after 18 months of exposure was very different from the effects observed after only 3 months of exposure, suggesting that modifications to the neural code continue throughout a lifetime of exposure to noise.
Sex Differences and Exogenous Estrogen Influence Learning and Brain Responses to Prediction Errors
Authors: Joue Gina , Chakroun Karima , Bayer Janine , Gläscher Jan , Zhang Lei , Fuss Johannes , Hennies Nora , Sommer Tobias 
Published: September 2021

AbstractAnimal studies show marked sex differences as well as effects of estrogen (E2) in the mesocorticolimbic dopaminergic (DA) pathways, which play a critical role in reward processing and reinforcement learning and are also implicated in drug addiction. In this computational pharmacological fMRI study, we investigate the effects of both factors, sex and estrogen, on reinforcement learning and the dopaminergic system in humans; 67 male and 64 naturally cycling female volunteers, the latter in their low-hormone phase, were randomly assigned, double-blind, to take E2 or placebo. They completed a reinforcement learning task in the MRI scanner for which we have previously shown reward prediction error (RPE)-related activity to be dopaminergic. We found RPE-related brain activity to be enhanced in women compared with men and to a greater extent when E2 levels were elevated in both sexes. However, both factors, female sex and E2, slowed adaptation to RPEs (smaller learning rate). This discrepancy of larger RPE-related activity yet smaller learning rates can be explained by organizational sex differences and activational effects of circulating E2, which both affect DA release differently to DA receptor binding capacities.
Preparatory Control Against Distraction Is Not Feature-Based
Authors: Liesefeld Heinrich R , Liesefeld Anna M , Müller Hermann J 
Published: September 2021

Abstract
Salient-but-irrelevant stimuli (distractors) co-occurring with search targets can capture attention against the observer’s will. Recently, evidence has accumulated that preparatory control can prevent this misguidance of spatial attention in predictable situations. However, the underlying mechanisms have remained elusive. Most pertinent theories assume that attention is guided by specific features. This widespread theoretical claim provides several strong predictions with regard to distractor handling that are disconfirmed here: Employing electrophysiological markers of covert attentional dynamics, in three experiments, we show that distractors standing out by a feature that is categorically different from the target consistently captures attention. However, equally salient distractors standing out in a different feature dimension are effectively down-weighted, even if unpredictably swapping their defining feature with the target. This shows that preparing for a distractor’s feature is neither necessary nor sufficient for successful avoidance of attentional capture. Rather, capture is prevented by preparing for the distractor’s feature dimension.
Shorter Contextual Timescale Rather Than Memory Deficit in Aging
Authors: Todd Juanita , Yeark Mattsen D , Paton Bryan , Jermyn Alexandra , Winkler István 
Published: September 2021

Abstract
Many aspects of cognitive ability and brain function that change as we age look like deficits on account of measurable differences in comparison to younger adult groups. One such difference occurs in auditory sensory responses that index perceptual learning. Meta-analytic findings show reliable age-related differences in auditory responses to repetitive patterns of sound and to rare violations of those patterns, variously attributed to deficits in auditory sensory memory and inhibition. Here, we determine whether proposed deficits would render older adults less prone to primacy effects, robustly observed in young adults, which present as a tendency for first learning to have a disproportionate influence over later perceptual inference. The results confirm this reduced sensitivity to primacy effects but do not support impairment in auditory sensory memory as the origin of this difference. Instead, the aging brain produces data consistent with shorter timescales of contextual reference. In conclusion, age-related differences observed previously for perceptual inference appear highly context-specific necessitating reconsideration of whether and to what function the notion of deficit should be attributed, and even whether the notion of deficit is appropriate at all.
Brain-Generated 17β-Estradiol Modulates Long-Term Synaptic Plasticity in the Primary Auditory Cortex of Adult Male Rats
Authors: Soutar Chloe N , Grenier Patrick , Patel Ashutosh , Kabitsis Pauline P , Olmstead Mary C , Bailey Craig D C , Dringenberg Hans C 
Published: September 2021

Abstract
Neuron-derived 17β-estradiol (E2) alters synaptic transmission and plasticity in brain regions with endocrine and non-endocrine functions. Investigations into a modulatory role of E2 in synaptic activity and plasticity have mainly focused on the rodent hippocampal formation. In songbirds, E2 is synthesized by auditory forebrain neurons and promotes auditory signal processing and memory for salient acoustic stimuli; however, the modulatory effects of E2 on memory-related synaptic plasticity mechanisms have not been directly examined in the auditory forebrain. We investigated the effects of bidirectional E2 manipulations on synaptic transmission and long-term potentiation (LTP) in the rat primary auditory cortex (A1). Immunohistochemistry revealed widespread neuronal expression of the E2 biosynthetic enzyme aromatase in multiple regions of the rat sensory and association neocortex, including A1. In A1, E2 application reduced the threshold for in vivo LTP induction at layer IV synapses, whereas pharmacological suppression of E2 production by aromatase inhibition abolished LTP induction at layer II/III synapses. In acute A1 slices, glutamate and γ-aminobutyric acid (GABA) receptor-mediated currents were sensitive to E2 manipulations in a layer-specific manner. These findings demonstrate that locally synthesized E2 modulates synaptic transmission and plasticity in A1 and suggest potential mechanisms by which E2 contributes to auditory signal processing and memory.
Big Thunder, Little Rain: The Yellow Peril Framing of the Pandemic Campaign Against China
Authors: Sautman Barry 
Published: September 2021

Abstract
Yellow Peril ideology has long cast Chinese as cruel, deceitful, incompetent disease vectors. Many US elites now tie such notions to China’s response to Covid-19. Their racialized framing of the drive to condemn and sue China however exemplifies a Chinese idiom—“big thunder, little rain” (雷声大, 雨点小)—which means noisy, yet ineffective. There are empirical obstacles to convincing the world of Chinese responsibility for the pandemic, such as that the virus spread much more from Europe and the US than from China, many Western states failed against the virus, and pandemic-related agitation against China has resulted in many anti-Asian actions. The ongoing claims are thus unlikely to be convincing beyond the Anglosphere, but still spread racism and advance a US-led anti-China mobilization.
A Novel, Simple Rapid Reverse-Phase HPLC-DAD Analysis, for the Simultaneous Determination of Phenolic Compounds and Abscisic Acid Commonly Found in Foodstuff and Beverages
Authors: Whelan Laura Curtin , Geary Michael , Healy Jim 
Published: September 2021

AbstractA novel, simple, rapid, 7-minute HPLC-DAD method for the determination of 10 phenolic compounds and abscisic acid commonly found in teas, wines, fruit and honey was successfully developed and validated according to the International Council of Harmonization (ICH) guidelines. This reverse-phase (RP) HPLC-DAD method boasts rapid separation and excellent resolution while introducing green chemistry techniques. The Agilent 1200 series diode array detector SL coupled with a reverse-phase Advanced Materials Technology Halo C18 column (100 × 3.0 mm i.d., 2.7 μm) contributed to the rapid analyses. This, together with a 0.1% formic acid in water (v/v) and methanol mobile phase, a flow rate of 0.8 mL/min and the utilization of a meticulous gradient elution resulted in a validated method for the determination of 10 phenolic compounds and abscisic acid commonly found in various foodstuffs. The resulting method proved to be rapid, accurate, precise and linear with sensitive detection limits from 0.025 μg/mL to 0.500 μg/mL and percentage recoveries of 98.07%–101.94%. Phenolic compounds have been acknowledged throughout literature for their therapeutic properties, interalia, antioxidant, anti-inflammatory and antiaging due to free radical scavenging potentials. However, resulting analysis, can be frequently complicated and long and very often discounts green chemistry techniques. The developed and validated method successfully and rapidly analyses, gallic acid, caffeic acid, trans-p-coumaric acid, rutin, myricetin, abscisic acid, trans-cinnamic acid, quercetin, luteolin, kaempferol and chrysin with excellent resolution and precision.
Politics of discontent in Spain: the case of Vox and the Catalonian independence movement
Authors: Arana Arantza Gomez 
Published: September 2021

AbstractSince the return to democracy, the negotiations on decentralisation of policies and decision-making developed with the framework of Comunidades Autónomas had been intended as a way of dealing with the existent tensions between Spanish and regional nationalisms. However, the escalation of the tension between regions reached a new level with the unofficial referendum in Catalonia over potential independence from Spain in October 2017 together with the increase in support for the first time in 40 years for a Spanish extreme right-wing party, VOX. The reasons behind both the support for VOX and the support for Catalonian independence can be linked to the degree of discontent over regional and Spanish nationalistic ideas respectively.
Epidemic thresholds of infectious diseases on tie-decay networks
Authors: Chen Qinyi , Porter Mason A 
Published: September 2021

Abstract
In the study of infectious diseases on networks, researchers calculate epidemic thresholds to help forecast whether or not a disease will eventually infect a large fraction of a population. Because network structure typically changes with time, which fundamentally influences the dynamics of spreading processes and in turn affects epidemic thresholds for disease propagation, it is important to examine epidemic thresholds in models of disease spread on temporal networks. Most existing studies of epidemic thresholds in temporal networks have focused on models in discrete time, but most real-world networked systems evolve continuously with time. In our work, we encode the continuous time-dependence of networks in the evaluation of the epidemic threshold of a susceptible–infected–susceptible (SIS) process by studying an SIS model on tie-decay networks. We derive the epidemic-threshold condition of this model, and we perform numerical experiments to verify it. We also examine how different factors—the decay coefficients of the tie strengths in a network, the frequency of the interactions between the nodes in the network, and the sparsity of the underlying social network on which interactions occur—lead to decreases or increases of the critical values of the threshold and hence contribute to facilitating or impeding the spread of a disease. We thereby demonstrate how the features of tie-decay networks alter the outcome of disease spread.
An Israeli–Palestinian Hecuba: Hanoch Levin’s Anti-Tragedy
Authors: Akavia Abigail 
Published: September 2021

AbstractThe Lost Women of Troy by Hanoch Levin, Israel’s foremost playwright of the twentieth century, is an adaptation of Euripides’ Trojan Women and Hecuba. Staged in Tel Aviv in 1984 during the First Lebanon War, Lost Women focuses on the bereavement and humiliation of Hecuba. Levin reconfigures this character to reflect mothers on both sides of the Israeli–Palestinian conflict. Through a subversion of the aesthetics of tragedy, Levin’s play is an indictment of the notion of heroism prevalent in Israeli society. It presents a bitter criticism of his public’s acceptance of the ideology of war and their participation in a narrative that glorifies those who die in combat as heroes. Levin’s critique, I argue, is formulated as a textual sparagmos, a violent tearing apart of Euripides’ tragedies and the conventions in which they operate. Levin’s metatheatrical violence against the tragic genre parallels the inherent violence of the discourse of heroism which his adaptation seeks to expose and denounce.