bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway
Authors: Han Yiran , Lu Zeyuan , Chen Shaotao , Zhong Chongwen , Yan Minghui , Wang Heran , Meng Meng , Liu Mingjun 
Published: May 2021

AbstractAbdominal massage (AM), a traditional Chinese medicine-based treatment method, has received considerable attention in the recent years. The aim of the present study was to investigate the effect of AM on high-fat diet (HFD)-induced insulin resistance (IR) in comparison with resveratrol (RSV) treatment. Forty-eight male Sprague-Dawley rats were randomly divided into the following four groups: standard chow diet (control group), high-fat diet (model group), HFD + abdominal massage (AM group), and HFD + resveratrol (RSV group). A rat model of IR was established by feeding HFD to rats for 8 weeks followed by treatment with AM or RSV for 4 weeks. The underlying HFD-induced IR molecular mechanisms were studied in rat serum and skeletal muscles. RSV and AM significantly improved glucose intolerance, hyperglycemia, obesity, and significantly reduced lipid accumulation [triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], adipocytokine [free fatty acids (FFA), adiponectin (ADPN)] and serum pro-inflammatory cytokines (IL-6 and TNF-α) secretion. In addition, AM activated the AMPK/SIRT1 signaling pathway in rat skeletal muscle. In conclusion, our results showed that AM could improve IR by regulating the secretion of adipocytokines, pro-inflammatory cytokines as well as related signaling pathways in the skeletal muscle of rats, which might provide insights into development of new treatment methods for the clinical treatment of IR.
Polymorphism in BACH2 gene is a marker of polyglandular autoimmunity
Authors: Fichna Marta , Żurawek Magdalena , Słomiński Bartosz , Sumińska Marta , Czarnywojtek Agata , Rozwadowska Natalia , Fichna Piotr , Myśliwiec Małgorzata , Ruchała Marek 
Published: May 2021

Abstract
Purpose
Genetically predisposed individuals may develop several autoimmune diseases—autoimmune polyendocrine syndromes (APS). APS types 2–4, are complex disorders, which combine various organ-specific autoimmune conditions. Recent reports support the considerable role of the BACH2 gene in immune cell differentiation and shifting the T-cell balance towards regulatory T-cells. BACH2 polymorphisms are associated with autoimmune disorders, including Addison’s disease (AD), Graves’ disease (GD), and probably type 1 diabetes (T1D). Our study was aimed to investigate the BACH2 variant, rs3757247, in endocrine autoimmunity in the Polish population.

Methods
The analysis comprised 346 individuals with APS, 387 with T1D only, and 568 controls. Genotyping was performed using TaqMan chemistry.

Results
APS type 2 was found in 219 individuals, type 3 in 102, and type 4 in 25 subjects. Overall, AD was diagnosed in 244 subjects, Hashimoto’s thyroiditis—in 238, T1D—in 127, GD—in 58, vitiligo and chronic gastritis each in 40 patients, celiac disease—in 28, premature menopause in 18, and alopecia in 4 patients. Minor T allele at rs3757247 was found in 56.4% APS vs. 44.1% control alleles (OR 1.59; 95%CI: 1.30–1.95, p < 0.0001). The distribution of genotypes revealed excess TT homozygotes in the APS cohort (33.2 vs. 20.1% in controls, p < 0.0001). The frequencies of rs3757247 alleles and genotypes in T1D patients did not present significant differences vs. controls (p-values > 0.05).

Conclusions
These results provide evidence of the association between BACH2 polymorphism and polyglandular autoimmunity. Since carriers of rs3757247 display increased risk for additional autoimmune conditions, this variant could identify individuals prone to develop APS.
Interactions between simultaneous aerobic exercise and mental rotation
Authors: Jost Leonardo , Weishäupl Andreas , Jansen Petra 
Published: May 2021

AbstractWhile the effects of aerobic exercise during a cognitive task on the performance of said cognitive task have been extensively studied, it has not been investigated whether cognitive performance during aerobic exercise influences the physical performance. For this, it is the main goal of the study to investigate the physical and cognitive performance during a simultaneous conduction of aerobic exercise and mental rotation. Forty-one German sport students cycled at 60% intensity while simultaneously performing a mental rotation task. In a within-subject design, both physical and cognitive performances were compared with isolated cycling and mental rotation as control conditions using both objective (heart rate and pedal cadence in the cycling task, reaction time and accuracy in the mental rotation task) and subjective (RPE) cognitive and physical measures. The results analyzed with hierarchical linear modeling revealed no effect of either simultaneous cognitive tasks on objective (heart rate) or subjective (RPE) physical effort, nor of simultaneous exercise on reaction time or accuracy in cognitive performance. However, we have found lower cadence during cognitive tasks, which was also stable in time compared to an increase in cadence during exercise control. Furthermore, our results demonstrated increased cognitive effort during exercise. Our findings suggest that increased effort, both physiological and cognitive, is required during combined physical and cognitive work in support of neurological resource conflicts caused by the differing demands of exercise and executive function.
Subjective experience of time in dementia with Lewy bodies during COVID-19 lockdown
Authors: Torboli Dylan , Mioni Giovanna , Bussé Cinzia , Cagnin Annachiara , Vallesi Antonino 
Published: May 2021

AbstractDementia with Lewy bodies (DLB) is a neurodegenerative disease characterized by cognitive, behavioral and motor symptoms and has a more challenging clinical management and poorer prognosis compared to other forms of dementia. The experience of lockdown leads to negative psychological outcomes for fragile people such as elderly with dementia, particularly for DLB, causing a worsening of cognitive and neuropsychiatric symptoms. Since an individual’s feeling of time passage is strongly related to their cognitive and emotional state, it is conceivable to expect alterations of this construct in people with DLB during such a difficult period. We therefore assessed the subjective experience of the passage of time for present and past time intervals (Subjective Time Questionnaire, STQ) during the lockdown due to coronavirus disease (COVID−19) in 22 patients with DLB (17 of which were re-tested in a post-lockdown period) and compared their experience with that of 14 caregivers with similar age. Patients showed a significantly slower perception of present and past time spent under lockdown restrictions. We argue that these alterations might be related to the distinctive features of DLB and their exacerbation recorded by the patients’ caregivers during the period of lockdown, though our results show that the patients’ experience of time passage in a post-lockdown period remained similarly slow. Overall, we show an impairment of the subjective perception of time passage in DLB tested during the COVID-19 lockdown.
Producing High-Dose Liqui-Tablet (Ketoprofen 100 mg) for Enhanced Drug Release Using Novel Liqui-Mass Technology
Authors: Lam Matthew , Nokhodchi Ali 
Published: May 2021

Abstract
Purpose
Liqui-Tablet is a dosage form derived from Liqui-Mass technology. It has proven to be a promising approach to improve drug dissolution rate of poorly water-soluble drugs. So far, Liqui-Tablet is feasible for low-dose drugs. In this study, an attempt was made to produce high-dose Liqui-Tablet, whilst maintaining ideal physicochemical properties for ease of manufacturing.

Methods
Liqui-Tablets containing 100 mg of ketoprofen were produced using various liquid vehicles including PEG 200, Span 80, Kolliphor EL, PG, and Tween 85. Investigations that were carried out included saturation solubility test, dissolution test, tomographic study, and typical quality control tests for assessing flowability, particle size distribution, friability, and tablet hardness.

Results
The weight of these Liqui-Tablets was acceptable for swallowing (483.8 mg), and the saturation solubility test showed PEG 200 to be the most suitable liquid vehicle (493 mg/mL). Tests investigating physicochemical properties such as flowability, particle size distribution, friability, and tablet hardness have shown no issue concerning quality control and manufacturability. The drug release test of the best formulation has shown extremely rapid drug release at pH 7.4 (100% after 5 min). At pH 1.2 the drug release was reasonable considering the formulation was yet to be optimized.

Conclusion
Despite the high amount of API and liquid vehicle, it is possible to produce a high-dose dosage form with acceptable size and weight for swallowing using the novel Liqui-Mass technology. This has the potential to diversify the technology by removing the restriction of high dose drug that has been seen in liquisolid technology.
A Case Series of Life-Threatening Hemorrhagic Events in Patients with COVID-19
Authors: Hajian Abbas 
Published: May 2021

AbstractSince venous microthrombotic and thromboembolic events in end organs have been pathophysiologically confirmed as a component of thrombo-inflammatory cascade in COVID-19 syndrome, anticoagulant prescription with prophylactic or therapeutic goal is recommended. Different guidelines for the above are introduced; however, there is no general consensus on any neither the type of anticoagulant nor for the dosage and duration of prescription. In our medical center, adopted internal guideline was considered for patients COVID-19. We consulted patients with COVID-19 who suffered from concurrent hematoma. Appropriate surgical approach was considered. Finally autopsy study was performed for patients. In this article, we presented a series of seven SARS-CoV-2 confirmed cases faced with bleeding complication following initiation of anticoagulation protocol. The rectus sheath hematoma with extension to pelvic and/or retroperitoneal space, even involving bowel mesentery was seen most commonly. Despite receiving appropriate surgical care, all seven cases died. Finally, in all cases, autopsy studies revealed no evidence for confirmation of DIC/SIC or organ failure as the reason of death although pulmonary involvement with SARS-CoV-2 and bleeding phenomena were approved. The nature of the COVID-19 syndrome makes patients vulnerable to hemorrhagic events following anticoagulant administration which relatively causes or accelerates patient’s expiration.
Students’ attitudes towards somatic genome editing versus genome editing of the germline using an example of familial leukemia
Authors: Vajen Beate , Ronez Joelle , Rathje Wiebke , Heinisch Laura , Ebeling Smilla , Gebhard Ulrich , Hößle Corinna , Schlegelberger Brigitte 
Published: May 2021

AbstractAlthough the discussion on possibilities and pitfalls of genome editing is ever present, limited qualitative data on the attitudes of students, who will come into contact with this technology within a social and professional context, is available. The attitude of 97 medical students and 103 students of other subjects from Hannover and Oldenburg, Germany, was analyzed in winter 2017/18. For this purpose, two dilemmas on somatic and germline genome editing concerning familial leukemia were developed. After reading the dilemmas, the students filled out a paper-and-pencil test with five open questions. The qualitative evaluation of the answers was carried by a deductive-inductive procedure of content analysis. There was a high approval for the use of somatic genome editing. When it came to germline genome editing, concerns were raised regarding enhancement, interventions in nature, and loss of uniqueness. The students recognized that somatic genome editing and germline genome editing prove different ethical challenges and need to be judged separately. Many students expressed not feeling fully informed. The results of this project show the importance of educating the public about the possibilities, limitations, and risks of somatic and germline genome editing. We recommend that this should already be addressed in schools in order to optimally prepare students and adults for participation in public discourse. Especially for patients affected by genetic diseases, it is of great importance that the treating physicians and geneticists are sufficiently informed about the method of genome editing to ensure good counseling.
Application of gold nanoparticles for improvement of analytical characteristics of conductometric enzyme biosensors
Authors: Soldatkin O. O. , Soldatkina O. V. , Piliponskiy I. I. , Rieznichenko L. S. , Gruzina T. G. , Dybkova S. M. , Dzyadevych S. V. , Soldatkin A. P. 
Published: May 2021

AbstractIn the work, the possibility of using nanoparticles of gold (AuNPs) to upgrade bioselective elements of biosensors in order to improve their analytical characteristics is considered. The bioselective elements of biosensors based on acetylcholinesterase (AChE), butyryl cholinesterase (BuChE) and glucose oxidase (GOD) were used as an experimental model. Immobilization of enzymes on the surfaces of conductometric transducers was performed by the crosslinking of corresponding enzymes using glutaraldehyde. The conditions of immobilization of AChE with gold nanoparticles were optimized. Thus, we determined the optimal values of concentration of crosslinking agent (glutaraldehyde), duration of immobilization, the enzyme to AuNPs ratio, the AuNPs concentration and size. The performance characteristics of the biosensors based on enzymes and AuNPs were investigated and compared with the characteristics of biosensors based on enzymes only. It was also examined how the addition of AuNPs to the bioselective element of biosensors affects the biosensor stability. In particular, the reproducibility of preparation and continuous operation of biosensors was tested as well as their stability at storage. It was shown that the presence of AuNPs in the composition of bioselective elements can improve some characteristics of biosensors, which may be promising for further study and use.
Intangible cultural heritage: a benefit to climate-displaced and host communities
Authors: Aktürk Gül , Lerski Martha 
Published: May 2021

AbstractClimate change is borderless, and its impacts are not shared equally by all communities. It causes an imbalance between people by creating a more desirable living environment for some societies while erasing settlements and shelters of some others. Due to floods, sea level rise, destructive storms, drought, and slow-onset factors such as salinization of water and soil, people lose their lands, homes, and natural resources. Catastrophic events force people to move voluntarily or involuntarily. The relocation of communities is a debatable climate adaptation measure which requires utmost care with human rights, ethics, and psychological well-being of individuals upon the issues of discrimination, conflict, and security. As the number of climate-displaced populations grows, the generations-deep connection to their rituals, customs, and ancestral ties with the land, cultural practices, and intangible cultural heritage become endangered. However, intangible heritage is often overlooked in the context of climate displacement. This paper presents reflections based on observations regarding the intangible heritage of voluntarily displaced communities. It begins by examining intangible heritage under the threat of climate displacement, with place-based examples. It then reveals intangible heritage as a catalyst to building resilient communities by advocating for the cultural values of indigenous and all people in climate action planning. It concludes the discussion by presenting the implications of climate displacement in existing intangible heritage initiatives. This article seeks to contribute to the emerging policies of preserving intangible heritage in the context of climate displacement.
Simple cyclic covers of the plane and the Seshadri constants of some general hypersurfaces in weighted projective space
Authors: Küronya Alex , Rollenske Sönke 
Published: May 2021

AbstractLet$$X \subset {\mathbb P}(1,1,1,m)$$X⊂P(1,1,1,m)be a general hypersurface of degreemdfor some for$$d\ge 2$$d≥2and$$m\ge 3$$m≥3. We prove that the Seshadri constant$$\varepsilon ( {\mathcal O}_X(1), x)$$ε(OX(1),x)at a general point$$x\in X$$x∈Xlies in the interval$$\left[ \sqrt{d}- \frac{d}{m}, \sqrt{d}\right] $$d-dm,dand thus approaches the possibly irrational number$$\sqrt{d}$$dasmgrows. The main step is a detailed study of the case whereXis a simple cyclic cover of the plane.
Diversity and Sources of Airborne Eukaryotic Communities (AEC) in the Global Dust Belt over the Red Sea
Authors: Aalismail Nojood A. , Díaz-Rúa Rubén , Geraldi Nathan , Cusack Michael , Duarte Carlos M. 
Published: May 2021

AbstractAirborne eukaryotic communities (AEC), rank among the least studied aerobiological components, despite their adverse impacts on human health and the environment. Here, we describe the AECs in the global dust belt, the area between the west coast of North Africa and Central Asia, which supports the highest dust fluxes on the planet. We sampled atmospheric dust over 14 months (fall 2015–fall 2016) from onshore and offshore locations of the Red Sea, the only waterbody that entirely encompassed in the global dust belt. We also sampled surface water samples to determine the potential transfer of taxa across the air-sea interface. To target the eukaryotes, we performed Miseq sequencing of atmospheric dust and surface water samples. Analysis of amplicon sequencing indicates a total pool of 18,816 sequence variants (SVs). Among 33 unique eukaryotic phyla in the AEC over the Red Sea, the most dominant taxa were Streptophyta, Apicomplexa, and Ascomycota. Aerosol eukaryotes originated from various sources and formed more diverse communities than eukaryotic communities of the Red Sea surface water. AECs were dominated by phylotypes released from plant material and soils, and including taxa reported to be harmful to human health. The AEC composition was significantly influenced by sampling locations and seasonal conditions but not by the origin of the air masses nor dust loads. This work is original and uses state-of-the-art methods and very powerful NGS- bioinformatics and statistical approaches. The selected study site has high interest and it has been well chosen because of the unique combination of high loads of dust deposition, being the only fully contained seawater body in the area acting as a sink for the atmospheric dust, and the lack of riverine inputs and watershed effects empathizing the role of atmospheric inputs in the ecology of the system.
Executive function as a mechanism linking socioeconomic status to internalizing and externalizing psychopathology in children and adolescents
Authors: McNeilly Elizabeth A. , Peverill Matthew , Jung Jiwon , McLaughlin Katie A. 
Published: May 2021

ABSTRACTIntroductionThe association between low socioeconomic status (SES) in childhood and increased risk for psychopathology is well established, but the mechanisms explaining this relationship are poorly understood. Here, we investigate the potential role of difficulties in executive functioning (EF) as a mechanism linking childhood and adolescent SES with externalizing and internalizing psychopathology.MethodsWe examined whether difficulties with EF mediated the association between SES and externalizing and internalizing psychopathology in two cross‐sectional samples of children and adolescents (Study 1: N = 94, ages 6–18, 51.1% male; Study 2: N = 259, ages 8–16, 54.1% male) from diverse SES backgrounds in the United States. EF was measured through behavioral tasks and parent‐reported behavioral regulation (BR).ResultsIn both samples, children and adolescents from lower SES families were more likely to experience both externalizing and internalizing psychopathology than youth from more advantaged backgrounds and exhibited greater EF difficulties – they had lower performance on a task measuring inhibitory control and lower parent‐rated BR. Reduced inhibitory control and BR, in turn, were associated with higher externalizing and internalizing psychopathology. In Study 1, difficulties with BR mediated the association of low‐SES with both externalizing and internalizing psychopathology. In Study 2, low inhibitory control mediated the association between low‐SES and externalizing psychopathology. These findings largely persisted after adjusting for exposure to violence, a form of adversity that is common in children from low‐SES backgrounds.ConclusionsThese findings suggest that reduced EF may be an underlying mechanism through which low‐SES confers risk for psychopathology in children and adolescents.
Coaches’ Attitudes Toward Campus Board Training in Adolescent Climbers in the United States
Authors: McMullen Christopher W. , Mugleston Brian J. , Booker Lyndsey N. 
Published: May 2021

Introduction Campus board training in adolescent climbers is controversial. Evidence, albeit limited, suggests this type of training may lead to the development of finger epiphyseal stress fractures. The purpose of the present study was to investigate coaches’ attitudes toward campus board training in the United States. Methods Surveys were sent to 116 coaches at gyms across the United States with affiliated adolescent climbing teams. Outcomes collected included demographic information, training time, campus board use prevalence, coaches’ attitudes toward campus board use, and willingness to participate in future research. Results Seventy-three coaches representing 3090 adolescent climbers completed the survey. Forty-six coaches (63%) reported using full weight (no foot contact) campus board training in some or all of their climbers. A variety of factors were cited by coaches when deciding which climbers should or should not use the campus board, including physical maturity, climbing ability, and age, among others. Conclusions Climbing coaches in the United States disagree on the use of campus board training in adolescent climbers. Some coaches avoid using this training modality entirely, whereas others believe certain climbers can use it safely. There is lack of consensus in determining who those certain climbers are.