bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Expression and Biological Analysis of circRNA in Acute Ischemic Stroke
Authors: Zheng Ji Qing , Liu Yun , Long Yaobin , Liang Shijie , Lin Chengsen , He Mingwei , Yang Guanglin 
Published: May 2021

Abstract
Objective: The study aimed to analyze the function and signal pathway of target genes by bioinformatics software, and then explore the possible role of circRNA molecules in regulating the pathogenesis of AIS so as to provide new potential molecular targets for AIS therapy.Methods: The study searched the circRNA gene array of AIS from the Gene Expression Omnibus and selected the upregulated and downregulated TOP 10 circRNAs to predict the miRNA binding sites of circRNA, which was then intersected with the differentially expressed miRNAs(DEMs) by miRNA gene array. Furthermore, the downstream target genes of miRNA were predicted jointly by three websites and constructed the ceRNA regulatory network, Database for Annotation Visualization and Integrated Discovery function enrichment analysis and protein–protein interaction analysis by the target genes. Results: miR-337-3p and miR-383 were the binding sites of hsa_circ_0004183, and miR-338-3p and miR-140-3p were the binding sites of hsa_circ_0051778 and hsa_circ_0092342, respectively, in addition, the four miRNAs were closely related to AIS. Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that MAPK signaling pathway, PI3K-Akt signaling pathway, P53 signaling pathway, and erbB signaling pathway were upregulated and downregulated pathways. The MCODE plug-in of Cytoscape was used to screen out a set of the most significant core networks, 21 key protein components, 7 of which were closely related to the occurrence and development of AIS. Conclusions: These findings aim to provide reference for the study of the pathogenesis of AIS by circRNA and broaden the idea of treatment.
Feasibility and Utility of MRI and Dynamic 18F-FDG-PET in An Orthotopic Organoid-Based Patient-Derived Mouse Model of Endometrial Cancer
Authors: Espedal Heidi , Berg Hege Fredriksen , Fonnes Tina , Fasmer Kristine Eldevik , Krakstad Camilla , Haldorsen Ingfrid Salvesen 
Published: May 2021

Abstract
Background: Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in endometrial cancer (EC) patients, however the preclinical use of these imaging methods is currently limited. We demonstrate the feasibility and utility of MRI and dynamic 18F-fluorodeoxyglucoce (FDG)-PET imaging for monitoring tumor progression and assessing chemotherapy response in an orthotopic organoid-based patient-derived xenograft (O-PDX) mouse model of EC.Methods: 19 O-PDX mice (grade 3 endometrioid EC, stage IIIC1), selectively underwent weekly T2-weighted MRI (total scans=32), diffusion-weighted MRI (DWI) (total scans=9) and dynamic 18F-FDG-PET (total scans=26) during tumor progression. MRI tumor volumes (vMRI), tumor apparent diffusion coefficient values (ADCmean) and metabolic tumor parameters from 18F-FDG-PET including maximum and mean standard uptake values (SUVmax/SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and metabolic rate of 18F-FDG (MRFDG) were calculated. Correlation between imaging parameters was assessed using a two-tailed Spearman test. Further, nine mice were included in a chemotherapy treatment study (treatment; n=5, controls; n=4) and tumor ADCmean-values were compared to changes in vMRI and cellular density from histology at endpoint. A Mann-Whitney test was used to evaluate differences between groups. Results: Tumors with large tumor volumes (vMRI) had significantly higher metabolic activity (MTV and TLG; r=0.93, p<0.0001). Non-invasive calculation of MRFDG from dynamic 18F-FDG-PET (mean MRFDG=0.39 mmol/min) was feasible using an image-derived input function. Treated mice had higher tumor ADCmean (p=0.03) and lower vMRI (p=0.03) and tumor cellular density (p=0.02) than non-treated mice, all indicating treatment response.Conclusion: Preclinical imaging mirroring clinical imaging methods in EC is highly feasible for monitoring tumor progression and treatment response in the present orthotopic organoid mouse model.
RBM10 Interacts with CTBNNBIP1 and Represses Lung Adenocarcinoma Progression Through the Wnt/β- catenin Pathway
Authors: Cao Yingyue , Wang Xin , Meng Qingwei , Geng Jianxiong , Xu Shanqi , Lang Yaoguo , Zhou Yongxu , Qi Lishuang , Wang Zijie , Wei Zixin , Yu Yan , Pan Bo 
Published: May 2021

Abstract
Background: RNA-binding motif protein 10 (RBM10), one of the RNA-binding protein (RBP) family, has a tumor suppressor role in various tumors. However, the functional role of RBM10 in lung adenocarcinoma (LUAD) and the molecular mechanism remain unclear. The aim of this study was to explore the effect of RBM10 on LUAD growth and metastasis and its molecular mechanism.Methods: Bioinformatics analysis was used to predict RBM10 expression and its associations with clinicopathological features and prognosis in LUAD. Gain- and loss- of function experiments were conducted to investigate the biological functions of RBM10 both in vitro and in vivo. RNA-seq, bioinformatics programs, western blot, qRT-PCR, TOP/FOP flash reporter, co-immunoprecipitation (co-IP), nuclear and cytoplasmic protein extraction and rescue experiments were used to reveal the underlying mechanisms.Results: Bioinformatics analysis showed that RBM10 was significantly downregulated and closely correlated with poor prognosis in LUAD patients. RBM10 silencing significantly promoted the LUAD proliferation, migration, invasion ability, while RBM10 overexpression had the opposite effects. Furthermore, upregulation of RBM10 inhibited growth and metastasis of LUAD in vivo. Additionally, RBM10 suppressed tumor progression through inhibiting epithelial to mesenchymal transition (EMT) in LUAD cells. Mechanistically, RBM10 interacts with β-catenin interacting protein 1 (CTNNBIP1) and positively regulates its expression, thus inactivating the Wnt/β-catenin pathway. Conclusions: This is the first study that reported how RBM10 suppresses cell proliferation and metastasis of LUAD by negatively regulating the Wnt/β-catenin pathway through interaction with CTNNBIP1. These data suggest that RBM10 may be a promising new target or clinical biomarker for LUAD therapy.
Structural and Electrical Properties of Sprayed In2S3 Films on ITO/Glass Substrate
Authors: Koaib J. , Bouguila N. , Kraini M. , Halidou I. , Khirouni K. , Vázquez-Vázquez C. , López-Quintela M. A. , Alaya S. 
Published: May 2021

Abstract
In2S3 thin films were grown on indium tin oxide (ITO) glass substrate by chemical spray pyrolysis technique at 360°C. The structural analysis of the deposited films shows a combination of tetragonal and cubic structures. The average crystallite size is about 25 nm. The electrical properties of In2S3 thin films have been investigated in a wide frequency (40Hz-100MHz) and temperature (400 K-660 K) ranges.We find that the electrical conductance of the In2S3 thin films is frequency and temperature dependent. The dc conductance shows a semi-conductor behavior for In2S3 films over the explored range of temperature and it follows the Arrhenius law with different activation energies. The variation of ac conductance and the frequency exponent `s’ are explained by the correlated barrier hopping (CBH) model. The Nyquist plots of impedance exhibit semicircle arcs and an electrical equivalent circuit has been suggested to interpret the impedance results.
Comparison of TPF and TP Induction Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma Based on TNM Stage and Pretreatment Systemic Immune-Inflammation Index
Authors: Xiong Ying , Shi Liang liang , Zhu Sheng li , Peng Gang 
Published: May 2021

Abstract
Background: Induction chemotherapy (IC) was associated with a decreased risk of distant metastasis in locally advanced nasopharyngeal carcinoma (LA-NPC). However, compared with TPF, whether the TP regimen can reduce the related toxicities caused by 5-FU while ensuring the survival benefit remains unclear.Methods: 213 patients diagnosed with LA-NPC (stage III-IVA) were included retrospectively. The prognosis of TPF and TP was compared by Kaplan-Meier and Cox proportional hazard regression. The treatment-related toxicities were evaluated according to CTCAE v4.0 and RTOG criteria. Results: TPF was found to have a higher 5-year DMFS in stage IVA and N2-3 patients, which not applicable to stage III and N0-1. The optimal value of pre-treatment SII was 432.48. A further subgroup analysis revealed that patients in stage IVA combined with pretreatment SII≥432.48 could get higher OS (P=0.038) and DMFS (P=0.028) from TPF. Multivariate analysis showed that SII was a prognostic factor for PFS (HR 2.801, P=0.018) and DMFS (HR 3.735, P=0.032), and IC regimen (HR 2.182, P=0.049) for predicting DMFS. The rate of grade 3-4 leukopenia (P=0.038), neutropenia (P=0.021), radiation oral mucositis (P=0.048) and diarrhea (P=0.036) were more common in TPF group. Conclusion: Our study revealed that TPF regimen showed a higher 5-year DMFS for stage IVA and N2-3 patients, while TP may be enough for stage III and N0-1. In LA-NPC patients with high risk (stage IVA combined with pre-treatment SII ≥ 432.48), TPF had a higher 5-year OS and DMFS, although grade 3-4 toxicities were more common but tolerable.
Teaming In Interdisciplinary Chronic Pain Management Interventions In Primary Care: A Systematic Review Protocol
Authors: Giannitrapani Karleen F. , Connell Natalie B. , Zupanc Sophia N. , Prathivadi Pallavi , Singer Sara J. , Yano Elizabeth M. , Wong Hong-Nei , Lorenz Karl A. 
Published: May 2021

Abstract
BackgroundPatients with chronic cancer or non-cancer pain often struggle with physical, emotional, and psychological problems not easily addressed by a single clinician. Current pain management recommendations emphasize leveraging interdisciplinary teams. We aim to describe how we intend to identify key features of interdisciplinary team structures and processes associated with improved pain outcomes for patients experiencing chronic pain in primary care settings. Methods We will include randomized studies and systematic reviews of interventions involving teaming that address chronic or cancer-related pain. A systematic review of articles published in English and after 2009 in PubMed, EMBASE, CINAHL, and Cochrane Library will be conducted. The primary outcome will be a numeric, patient-reported pain score. Extracted data will include details about the team structures and processes used in the interdisciplinary interventions based in primary care. DiscussionThe intended systematic review will examine interventions that incorporate teamwork or teaming to manage chronic pain and will synthesize evidence as to which team structures and processes may help facilitate improved pain management, and thus improved pain outcomes. Results of this systematic review may help inform how to organize teams within primary care that will be most beneficial to chronic pain patients and highlight opportunities for future, high-quality randomized controlled trials exploring teaming models in primary care.Systematic review registration: PROSPERO #CRD42020191467
SDR Enabled C-RAN Implementation using OpenAirInterface
Authors: Mufutau Akeem Olapade , Guiomar Fernando Pedro , Oliveira Arnaldo , Monteiro Paulo Pereira 
Published: May 2021

Abstract
Towards enabling 5G radio access technologies and beyond to meet the requirements for continuous dynamic and diverse services, flexibility and scalability of the cellular network are therefore pertinent. The utilization of software-defined radio (SDR) aided with an open-source platform and virtualization techniques are increasingly exposing the realization of desirable flexibility for radio access network (RAN) while enabling the development of a prototype which can be directed at fostering further mobile network research activities. In this paper, we review OpenAirInterface (OAI) implementation and present an OAI based cloud RAN (C-RAN) testbed with which mobile fronthaul (MFH) solutions can be tested.
Application of Artificial Intelligence in Human Diagnosis and Public Health Management
Authors: Wang Weiwei , Zhao Xinjie , Jia Yanshu 
Published: May 2021

Abstract
To improve the diagnostic efficiency and accuracy of corona virus disease 2019 (COVID-19), and to study the application of artificial intelligence (AI) in COVID-19 diagnosis and public health management, the computer tomography (CT) image data of 200 COVID-19 patients are collected, and the image is input into the AI auxiliary diagnosis software based on the deep learning model, "uAI the COVID-19 intelligent auxiliary analysis system", for focus detection. The software automatically carries on the pneumonia focus identification and the mark in batches, and automatically calculates the lesion volume. The result shows that the CT manifestations of the patients are mainly involved in multiple lobes, and in density, the most common shadow is the ground glass opacity. The detection rate of manual detection method is 95.30%, misdiagnosis rate is 0.20% and missed diagnosis rate is 4.50%; the detection rate of AI software focus detection method based on deep learning model is 99.76%, the misdiagnosis rate is 0.08%, and the missed diagnosis rate is 0.08%. Therefore, it can effectively identify COVID-19 focus and provide relevant data information of focus to provide objective data support for COVID-19 diagnosis and public health management.
Adaptation of a Community-based Type-2 Diabetes Mellitus Remission Intervention During COVID-19: Empowering Persons Living With Diabetes to Take Control
Authors: Quimby Kim , Murphy Madhuvanti , Harewood Heather , Howitt Christina , Hambleton Ian , Jeyaseelan Selvi , Greaves Natalie , Sobers Natasha 
Published: May 2021

Abstract
Background: The Barbados Diabetes Remission Study-2 reported that a community-based low-calorie diet (LCD) for weight loss and diabetes remission was both an acceptable implementation strategy and a clinically effective intervention. This study aimed to examine the adaptability of the face-to-face BDRS-2 protocol into an online modality.Methods: The Iterative Decision‐making for Evaluation of Adaptations framework questions the necessity of the adaptation and the preservation of core elements of the intervention during the adaptation process – these elements were identified as the 12-week intervention duration, weekly monitoring of participants for change in weight and fasting blood glucose and daily 840kcal allowance. The adaptation outcomes were documented using the framework for reporting adaptations and modifications to evidence-based interventions. Implementation effectiveness was determined by fidelity to core intervention elements. Intervention effectiveness was determined from the analysis of clinical data.Results: We decided that an adaptation was needed as the COVID-19 measures to control transmission prohibited in-person interactions, and that key elements of the intervention could be preserved during the adaptation process. Adaptations were made to the following: (1) The context in which the data was collected: participants self-measured at home instead of being measured by community health advocates (CHA) at a community site. (2) The context in which the data was entered: participants first posted their measurements to a mobile application site which was accessible by the CHAs. As with the original protocol, CHAs then entered the measurements into an online database. (3) The formulation of the LCD: participants substituted the liquid formulation for a solid meal plan of equivalent caloric content. There was increased fidelity to the attendance schedule with the online format (1 incomplete entry out of 45 entries), as compared to the face-to-face modality (1 absence out of 20 visits). Regarding the solid meal plan, 1 participant logged difficultly averaging non-exact potion sizes. Weight change ranged from -14.3kgs to 0.4kgs over the 12-week period and all group members achieved induction of diabetes remission. Conclusion: Larger studies are needed to confirm that this adapted online protocol is both acceptable and clinically effective while maintaining fidelity to key elements of the original protocol.Trial Registration: NCT03536377 registered 24th May 2018 at https://clinicaltrials.gov/ct2/show/NCT03536377
Generation Mechanism and Dual Dynamic Simulations of Surface Patterns in Single-Point Diamond Turning of Single-Crystal Copper
Authors: Xiong Jie , Chen Yanbing , Dai Yuqi , Zhang Guoqing , Ran Jiaqi , To Sandy 
Published: May 2021

Abstract
Single-crystal copper (Cu), whose atom arrangement is in the same direction and has no grain boundary, is widely used in defense technology, civil electronics and network communication. As a diamond turnable material, fan-shaped patterns appear on the machined surface, which affects the machined surface quality and the optical function it carries. Previous studies on the surface generation mechanism in single-point diamond turning (SPDT) of Cu were limited to experimental analysis, while there is a lack of fundamental understanding of the fan-shaped pattern generation mechanism and suppression method. In the present study, the different fan-shaped patterns, surface quality, cutting force and chip morphology of the typical crystal planes (100), (110) and (111) planes of Cu were studied by both theoretical and experimental analyses. A molecular dynamics (MD) simulation was conducted to present the fundamental generation mechanism of the fan-shaped patterns from atom arrangement directions and its angle change with the main cutting direction, while a cutting dynamics model was established to simulate the generation of fan-shaped patterns on the machined surface. Based on theoretical and experimental analysis, it was found that the atom density arrangement directions of Cu and its angle change with the main cutting direction of SPDT caused fluctuations in the friction coefficient, which further caused the vibration of the cutting system and generated the fan-shaped patterns. The SPDT of crystal planes (100) can achieve the best surface quality. The present research provides a fundamental understanding of fan-shaped pattern formation on the machined surface, and provides an instruction for machining Cu to obtain better surface quality.
Spatial and Temporal Influence of Sea Level on Inland Stress based on Seismic Velocity Monitoring
Authors: Andajani Rezkia Dewi , Tsuji Takeshi , Snieder Roel , Ikeda Tatsunori 
Published: May 2021

Abstract
Earth’s crust responds to perturbations from various environmental factors. To evaluate this response, seismic velocity changes offer an indirect diagnostic, especially where velocity can be monitored on an ongoing basis from ambient seismic noise. Investigating the connection between the seismic velocity changes and external perturbations could be useful for characterizing dynamic activities in the crust. The seismic velocity is known to be sensitive to variations in meteorological signals such as temperature, snow, and precipitation as well as changes in sea level. Among these perturbations, the impact of variations in sea level on velocity changes inferred from seismic interferometry of ambient noise is not well known. This study investigates the influence of the ocean in a 3-year record of ambient noise seismic velocity monitoring in the Chugoku and Shikoku regions of southwest Japan. First, we applied a bandpass filter to determine the optimal period band for discriminating among different influences on seismic velocity. Then, we applied a regression analysis between the proximity of seismic station pairs to the coast and the ocean influence, as indicated by the correlation of sea level to seismic velocity changes between pairs of stations. Our study suggests that for periods between 0.0036 to 0.01 cycle/day (100–274 days), the ocean’s influence on seismic velocity decreases with increasing distance of station pairs from the coast. The increasing sea level deforms the ocean floor, affecting the stress in the adjacent coast. The stress change induced by the ocean loading may extend at least dozens of kilometers from the coast. The correlation between sea level and inland seismic velocity changes are negative or positive. Although it is difficult to clearly interpret the correlation based on simple model, they could depend on the in situ local stress, orientation of dominant crack, and hydraulic conductivity. Our study shows that seismic monitoring may be useful for evaluating the perturbation in the crust associated with an external load.
Influence of the Welding Angle on the Mechanical Behavior of Plates obtained by the Tailor Welded Blank (TWB) Process
Authors: Santos Wellington Augusto dos , de Andrade Etiene Pereira , Assunção Guilherme Souza , Santos Izabela Ângela , Silva Gilmar Cordeiro da 
Published: May 2021

Abstract
Tailor Welded Blank (TWB) is a top-welding technique (by unconventional processes) of sheets of different specifications (materials, thicknesses and/or coatings). Because it allows localised distribution of mechanical properties and mass, it can optimise the relationship between structural rigidity and total weight. The great challenge of this technique is to combine two processes with completely different demands, welding and mechanical forming. This work investigates the mechanical behavior of sheets obtained by the Tailor-blank process from the determination of the optimum angle. We performed tensile tests on sheets with different weld line inclinations, as the general objective is to consolidate knowledge about the process, characterise the conditions for sheet formation obtained by the technique, in a safe conformation range, with complex contours, dimensional qualities and free of catastrophic failure. Steel sheets, interstitial free (IF), of 1.10mm and 0.65mm thick were used. The TWB was applied with a welding line oriented from 0º to 90º (ranging from 15° to 15°). The optimum angle obtained was 30º, where there was a good relationship between the breaking load, purely tensile and shear stresses, and the total elongation. In relation to the angle of 0º, the optimum angle presented a superior elongation of approximately 40%. It was still possible to notice that the thickness of the plates influenced the optimum angle, even if the LSR (Limit Strength Ratio) is close.