bluuebunny/crossref_metadata_2025_split huggingface dataset:
Des usages de l’espace urbain à l’histoire intellectuelle de l’économie politique. Un hommage à Jean-Claude Perrot
Authors: Hoock ( - ) Jochen 
Published: November 2021

Résumé
Une fois posé l’arrière-plan des transformations de la discipline historique pendant les années 1970 et 1980, cet article restitue l’itinéraire intellectuel de Jean-Claude Perrot depuis ses travaux d’histoire économique et sociale sur la formation de la ville de Caen au XVIIIe siècle jusqu’à ses études et propositions pour l’histoire intellectuelle. Il met en évidence le lien généalogique entre ces deux moments, l’affinité des procédés d’analyse qu’ils ont comportés et la rencontre de ces tentatives menées en France avec des renouvellements analogues intervenus au même moment en Allemagne.
Descartes on the Passions of the Soul and Internal Emotions: Two Challenges for Interoception Research in Emotions
Authors: De Preester Helena , Dorsch John 
Published: November 2021

Abstract
On the basis of Descartes’s account of the passions of the soul, we argue that current interoception-based theories of emotions cannot account for the hallmark of a passion of the soul, i.e., that its effects are felt as being in the soul itself. We also pay attention to the epistemic functions of the passions and to Descartes’s category of emotions that are caused and occur in the soul alone. Certain passions of the soul and certain internal (or intellectual) emotions are similar to what are today called ‘epistemic (or noetic) feelings’ and ‘epistemic emotions.’ Descartes’s work reflects another challenge for contemporary embodied cognition: how might epistemic affect be embodied? Since the signature of embodiment is increasingly understood as interoceptive, the challenge to interoceptive research is demonstrating the degree to which (epistemic) affect results from interoception. This challenge also implies that the locus of emotional experience is taken into account.
Vascular and Neurological Injury in Children With Posterior Traumatic Knee Dislocation
Authors: Parrado Raphael H. , Notrica David M. 
Published: November 2021

Posterior knee dislocations (PKD) in children are uncommon but may be associated with vascular injury. The purpose of this study is to characterize the frequency of vascular injury in PKD as well as define patient characteristic, procedures, types of treating hospitals, and clinical outcomes. This study utilized the National Trauma Data Set (NTDS) from the American College of Surgeons on years 2015 and 2016. All demographic and clinical data on pediatric patients (≤18 years) with the ICD codes for PKD were obtained. 44 PKD were identified. The median age was 17 years [IQR 15,18], 70% male; 49% white. The mean body mass index was 29.6 [IQR 23-38]. We found that vascular injury was present in 16 patients (36%); 14 (30%) underwent repair (eight with saphenous vein graft) and fasciotomies in eight patients. Nerve injury was present in five patients (11%). Lower extremity amputation was performed in three patients (7%).
Thermal cycling and ultraviolet radiation effects on fatigue performance of triaxial CFRP laminates for bridge applications
Authors: Mosallam Ayman , Xin Haohui , He Shaohua , Agwa Ashraf AK , Adanur Suleyman , Salama Mohamed A 
Published: November 2021

Environmental processing such as thermal cycling and ultraviolet (UV) exposure contributes to degradation of polymer composites mechanical properties. This study focuses on assessing fatigue life of both unstressed and stressed triaxial carbon/epoxy composite laminates exposed to both thermal cycling and UV radiation. In this study, five test series were conducted to assess such effects on fatigue life of carbon fiber reinforced polymer laminates exposed to tensile-compressive (T-C) fatigue loading. This included the following: (i) Pre-exposure (baseline) test group tests; (ii) unstressed thermal cyclic aging; (iii) stressed (tensioned) thermal cyclic test group; (iv) stressed (compressed) thermal cyclic test group; and (v) UV radiation exposure test group. Fatigue life with 95%, 97.7%, and 99% guarantee rates is calculated based on stochastic analysis. In terms of different guarantee rates, the material parameters of S-N curves are fitted after transforming the data to a log–log space. Experimental results indicated that the difference of parameter [Formula: see text] is relatively small for different guarantee rates, and that the coefficient m decreased with increasing probabilistic guarantee rate. Furthermore, the ratio [Formula: see text] decreases with larger guarantee rates and increases as the stress range increases. Results of this study indicated that UV radiation exposure has the largest effect on fatigue life stress range less than 500.0 MPa. Also, fatigue life of pre-compressed specimens exposed to thermal cyclic is most affected when exposed to stress levels larger than 500.0 MPa. For stress ranges less than 500.0 MPa, the effects on fatigue life of unstressed and pre-compressed thermal cycled specimens are relatively large as compared to baseline group.
The AflibeRcept use in rEal life study for the treatment of diabetiC macular oedema In the French overseas territories: A 12 months follow-up Study - The RECIF Study
Authors: Morel Christophe , Conrath John , Morin Bruno , Parrat Eric , Zito Eleonora , Desoudain Catherine , Pernot Anne , Chauvet Guy , Hajjar Christian , Lemaitre Stephanie , Billiard Pascale , Blanquat Pierre Saint , Uzel Jean Louis , Bezeaud Dominique , Villeroy Frederic , N’Guyen Patrick , Devin François , Matonti Frederic 
Published: November 2021

Purpose The incidence and severity of diabetes is particularly high in the French overseas territories (FOT). The RECIF study evaluated real life management of diabetic macular oedema (DME) treated by aflibercept in FOT. Methods A prospective, noncomparative, multicentric, non-interventional, study that evaluated functional and anatomical results of patients treated by aflibercept. Twelve retina specialists working in French Polynesia, La Reunion, Guadeloupe and Martinique participated in the study. Results 67 eyes of 57 patients were followed for 12 months. Average VA gain was 7.8 ETDRS letters. 29.9% of eyes gained at least 15 letters, 6% lost 15 letters or more. 67.2% of eyes achieved visual acuity of 70 letters or better. Average central retinal thickness decrease was 115.3 µm. The mean number of injections during the 1st year of treatment was 4.9. 69% of eyes had a loading dose of at least three-monthly injections. 3 eyes were switched to steroid injections during the follow-up for lack of efficacy. Conclusion This study confirmed the efficacy of intravitreal treatment of DME by aflibercept, in the French overseas territories. This evaluation of real-life management of DME underlines the importance of improvement of patient education and collaboration with referring physicians.
Gender assignment: Monolingual constraints contribute to a bilingual outcome
Authors: Trawick Sonya , Bero Trevor 
Published: November 2021

Aims and objectives: This study explores the well-researched topic of gender assignment to English nouns in Spanish discourse through a usage-based framework. The goal is to elucidate the relative impact of both previously studied and novel constraints on the variable application of feminine determiners. Methodology: A variationist analysis of English nouns surrounded by Spanish discourse in the spontaneous speech of bilinguals. Data and analysis: Data come from the New Mexico Spanish–English Bilingual Corpus. Tokens ( N = 707) were coded for independent variables and submitted to a logistic regression. The goodness of fit was determined via the area under the receiver operating characteristic (ROC) curve method. Findings: All independent variables were selected as significant by the logistic regression model. Based on factor weight ranges, the hierarchy of constraints is the following, from the most to the least impactful: Analogical Gender, Phonological Shape, Syntactic Role, and Determiner Definiteness. These results suggest that bilinguals utilize a variety of constraints in gender assignment, as opposed to a single default strategy. Originality: While previous studies have tested and found similar results for constraints such as analogical gender and phonological shape, none have offered a unified analysis explaining findings from a usage-based approach. The originality and utility of this approach is most apparent in the discussions of prototypicality and schematicity. Significance/implications: A corpus-based approach and usage-based theory is shown to bring new insight to a topic of interest in many other linguistic sub-fields. The discussion reinterprets previous conclusions about gender assignment using a framework not proposed in previous research, despite similar overall results.
Age of Early Specialization, Competitive Volume, Injury, and Sleep Habits in Youth Sport: A Preliminary Study of US Youth Basketball
Authors: Meisel Peter L. , DiFiori John P. , Côté Jean , Nguyen Joseph T. , Brenner Joel S. , Malina Robert M. , Ryan Ed , Güllich Arne 
Published: November 2021

Background: Concerns for youth sports in the United States often focus on early sport specialization, overemphasis on competition, injuries, and burnout. Little research has addressed relationships among the preceding and other concerns, including time away from organized sport, sleep, and perceptions of physical and psychological well-being. Hypothesis: There is an association between reported competitive gameplay volume and specialization, injury, and fatigue among elite youth basketball players. Study Design: Cross-sectional study; convenience sample. Level of Evidence: Level 4. Methods: An anonymous questionnaire was administered to a convenience sample of youth basketball players between 13 and 18 years of age from across the United States. Participants were queried about multiple factors, including the extent of their participation in organized basketball and other sports, time away from organized basketball, injury, sleep, and feelings of exhaustion related to basketball participation. Results: A total of 772 participants (145 girls, 627 boys) completed a survey. All participants played for a select or elite club basketball team and/or a high school basketball team. Overall, 49% played more than 50 games within the past year. A total of 73% were specialized in basketball, 58% prior to age 14 years, and 35% prior to age 11 years. In all, 70% reported less than 1 month away from organized basketball within the past year, and 28% reported no time away. A total of 54% reported sleeping less than the recommended 8 hours each night during the school year. Within the prior year, 55% reported feeling physically exhausted and 45% reported feeling mentally exhausted from basketball. Regression analysis did not find any significant relationships between early specialization prior to age 14 years and basketball-related injury or feelings of mental or physical exhaustion. Conclusion: In this select group of youth basketball players, the majority specialized in basketball prior to age 14 years and reported a large number of competitive events with little time away from organized basketball. Clinical Relevance: The results from a sample of highly competitive youth basketball players indicate issues that warrant further attention and research regarding the potential impact of specialization, frequent competitions, lack of time away from organized sport, and perceptions of well-being in young athletes.
Total cerebral small vessel disease score and all-cause mortality in older adults of Amerindian ancestry: The Atahualpa Project
Authors: Del Brutto Victor J , Mera Robertino , Recalde Bettsy Y , Rumbea Denisse A , Costa Aldo F , Del Brutto Oscar H 
Published: November 2021

Introduction Cerebral small vessel disease (SVD) predicts all-cause mortality in Eastern Asian and Caucasian populations. However, little is known about SVD impact in individuals of different races/ethnic groups. In this study, we sought to estimate the mortality risk according to the total SVD (tSVD) score in older adults of Amerindian ancestry. Methods Participants aged ≥60 years from the prospective population-based Atahualpa Project cohort underwent brain MRI between June 2012 and June 2017. The tSVD score was calculated based on the presence of moderate-to-severe white matter hyperintensities, enlarged perivascular spaces, one or more lacune, and one or more cerebral microbleed. We ascertained all-cause mortality during post-MRI follow-up. Poisson regression and Cox-proportional hazards models adjusted for demographics and cardiovascular risk were obtained to estimate mortality risk according to the tSVD score. Results Analysis included 375 participants with available brain MRI and clinical data (mean age 69.0 ± 8.3 years, 56.3% women). The tSVD score was 0 point in 216 individuals (57.6%), 1 point in 71 (18.9%), 2 points in 53 (14.1%), and 3–4 points in 35 (9.3%). Increasing tSVD score was associated with advancing age, hypertension, low level of education, and physical inactivity. Using tSVD score of 0 as reference, a multivariate Poisson regression model showed an increased mortality for individuals with a tSVD score 3–4 points (IRR: 2.27; 95% CI: 1.20–4.28). Likewise, in the Cox-proportional model adjusted for demographics and cardiovascular risk, participants with a tSVD score 3–4 maintained a greater than two-fold mortality risk when compared to those with tSVD score of 0 points (HR: 2.32; 95% CI: 1.23–4.39). Conclusions High-burden SVD as determined by the tSVD score predicts mortality in community-dwelling older adults of Amerindian ancestry. Incidental diagnosis of covert SVD should prompt aggressive control of cardiovascular health.
Paraneoplastic tubulointerstitial nephritis exacerbated by immune checkpoint inhibitor
Authors: Scherer Thomas Paul , Saba Karim Alexander , Strebel Raeto Thomas , Gaspert Ariana , Cathomas Richard , Fehr Thomas 
Published: November 2021

Background: With the expanding indications and thus broader use of immune checkpoint inhibitors, clinicians are faced with a new kind of immune-related adverse events. Because of their immune modulating effects, immune checkpoint inhibitors have the potential to worsen autoimmunity in general. Paraneoplastic syndromes can be caused by tumor-induced autoimmune mechanisms. The use of immune-activating substances such as checkpoint inhibitors might lead to exacerbation of paraneoplastic syndromes causing premature discontinuation of the immunotherapy. Case presentation: We report on a 64-year-old patient with metastasized renal cell carcinoma who developed acute kidney failure after cytoreductive nephrectomy. Work-up revealed a paraneoplastic syndrome that caused tubulointerstitial nephritis (TIN). Glucocorticoid therapy successfully reversed the acute kidney injury. However, adjuvant therapy with Nivolumab provoked a flare-up of the paraneoplastic syndrome on two occasions, eventually leading to a treatment discontinuation. Conclusions: Many cases of Nivolumab-induced TIN have been described lately. However, our case demonstrates therapy failure due to a flare-up of a pre-existing paraneoplastic syndrome of the renal cancer. Against this background, it can only be speculated that some of the TIN cases discussed in prior literature might also have been flare-ups of subclinical autoimmunity.
Optimization Transmission Efficiency with Driver Intention for Automotive Continuously Variable Transmission under Slip Mode
Authors: Han Ling , Zhang Hui , Fang Ruoyu , Liu Hongxiang 
Published: November 2021

AbstractThis study proposes and experimentally validates an optimal integrated system to control the automotive continuously variable transmission (CVT) by Model Predictive Control (MPC) to achieve its expected transmission efficiency range. The control system framework consists of top and bottom layers. In the top layer, a driving intention recognition system is designed on the basis of fuzzy control strategy to determine the relationship between the driver intention and CVT target ratio at the corresponding time. In the bottom layer, a new slip state dynamic equation is obtained considering slip characteristics and its related constraints, and a clamping force bench is established. Innovatively, a joint controller based on model predictive control (MPC) is designed taking internal combustion engine torque and slip between the metal belt and pulley as optimization dual targets. A cycle is attained by solving the optimization target to achieve optimum engine torque and the input slip in real-time. Moreover, the new controller provides good robustness. Finally, performance is tested by actual CVT vehicles. Results show that compared with traditional control, the proposed control improves vehicle transmission efficiency by approximately 9.12%–9.35% with high accuracy.
Difficulty of internal bond prediction of particleboard using the density profile
Authors: Korai Hideaki 
Published: November 2021

AbstractThe relationship between density profile and internal bond (IB) of commercial particleboards was investigated. Minimum density was theoretically related to the IB, but the correlation coefficient between them was low at 0.435. The correlation coefficients between core layer densities and IB were also low. These correlation coefficients were approximately 0.460. The IB is influenced not only by density, but also by other factors such as the manufacturing conditions. In addition, commercial particleboards have a narrow density range. This narrow density range results in overfitting, showing a low correlation coefficient. Thus, predicting the IB using density profile was difficult.
The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression
Authors: Li Weihan , Wu Lei , Jia Hui , Lin Zenghua , Zhong Renhao , Li Yukun , Jiang Chenwei , Liu Shifan , Zhou Xiaorong , Zhang Erhao 
Published: November 2021

Abstract
Background
Liquid–liquid phase separation (LLPS) within the nucleus is directly linked to driving gene expression through transcriptional complexes. Histone lysine methyltransferase 2D (KMT2D) is widely present in many cancers. It is known to epigenetically stimulate the expression of genes associated with tumorigenesis and metastasis. Our analyses show that KMT2D possesses two distinct low-complexity domains (LCDs) capable of driving the assembly of membrane-less condensates. The dependence of the mechanisms underlying monomethylation of H3K4 on the LLPS microenvironment derived from KMT2D LCDs is unclear in tumor.

Methods
KMT2D LCD-depletion cells were used to investigate tumor cell proliferation, apoptosis, and migration. We identified some core proteins, including WDR5, RBBP5, and ASH2L, which are involved in the KMT2D-associated catalytic complex in KMT2D LCD-deficient cells to further elucidate the mechanism that decreases monomethylation of H3K4. We also evaluated the viability of KMT2D LCD-deficient cells in vivo. Finally, using 1,6-hexanediol (HD), an inhibitor of LLPS, we determined cell activities associated with KMT2D function in wild-type PANC-1 cells.

Results
Without the LLPS microenvironment in KMT2D LCD-deficient cells or wild-type PANC-1 cells treated with HD, the WDR5 protein was significantly less stable and the protein–protein interactions between the components of the KMT2D–enzyme complex were attenuated, impairing the formation of the complex. Moreover, with the decrease in H3K4me1 level at enhancers, transcription factors such as LIFR and KLF4 were markedly downregulated, effectively inhibiting tumor progression. In xenograft tumor models, PANC-1 cells lacking the KMT2D LCDs showed effectively suppressed tumor growth compared to normal cells.

Conclusions
Our data indicate that the two low-complexity domains of the KMT2D protein could form a stable LLPS microenvironment, promoting the KMT2D catalysis of H3K4 monomethylation through stabilization of the WDR5 protein and KMT2D–enzyme complex. Therefore, finding ways to regulate the LLPS microenvironment will be benefitial for new cancer treatment strategies.
Synergistic Photocatalytic-Adsorption Removal of Basic Magenta Effect of AgZnO/Polyoxometalates Nanocomposites
Authors: Tian Heyun , Luo Jie , Zhang Ke , Ma Chenguang , Qi Yiyi , Zhan Shixia , Liu Xiao , Li Mingxue , Liu Hongling 
Published: November 2021

AbstractThe bifunctional photocatalytic-adsorbent AgZnO/polyoxometalates (AgZnO/POMs) nanocomposites were synthesized by combining AgZnO hybrid nanoparticles and polyoxometalates [Cu(L)2(H2O)]H2[Cu(L)2(P2Mo5O23)]⋅4H2O (HL = C6H6N2O) into nanostructures via a sonochemical method. Transmission electron microscopy (TEM) indicated that AgZnO/POMs nanocomposites were uniform with narrow particle size distribution and without agglomeration. X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis confirmed the nanostructure and composition of AgZnO/POMs nanocomposites. The ultraviolet–visible spectra (UV–Vis) and photoluminescence spectra (PL) confirmed excellent optical properties of the AgZnO/POMs nanocomposites. 94.13% ± 0.61 of basic magenta (BM) in aqueous solution could be removed using the AgZnO/POMs nanocomposites through adsorption and photocatalysis. The kinetic analysis showed that both the adsorption and photocatalysis process conform to pseudo-second-order kinetics. In addition, the removal rate of AgZnO/POMs nanocomposites was found to be almost unchanged after 5 cycles of use. The bifunctional photocatalytic-adsorbent AgZnO/POMs nanocomposites with high stability and cycling performance have broad application prospects in the treatment of refractory organic dye wastewater containing triphenylmethane.
Prevalence of hepatopancreatic injury and clinical outcomes in patients with COVID-19 in USA
Authors: Rastogi Vaibhav , Banwait Ranjit , Singh Devina , Toklu Hale , Finer Lexie , Parajuli Dipendra , Ganti Latha 
Published: November 2021

Abstract
Background
(1) To determine the prevalence of hepatopancreatic injury in coronavirus disease 2019 (COVID-19) patients. (2) To correlate hepatopancreatic injury in COVID-19 with mortality, disease severity, and length of stay in this cohort.

Results
Forty-five thousand three hundred sixty patients were included in the analysis, 62.82% of which had either hepatic or pancreatic injury. There was a significant upward trend in transaminases, alkaline phosphatase, prothrombin time, bilirubin, lactate dehydrogenase, and lipase and a downward trend in albumin with an increase in disease severity. COVID-19-positive patients with hepato-pancreatic injury have a significantly higher mortality (OR 3.39, 95%CI 3.15–3.65) after controlling for the differences in age, sex, race/ethnicity, liver cirrhosis, and medication exposures. They also have increased disease severity (OR 2.7, 95%CI 2.5–2.9 critical vs mild/moderate; OR 1.4, 95% CI 1.3–1.5 severe vs mild/moderate) and longer hospital length of stay (2 days).

Conclusion
COVID-19 can cause liver injury. Mortality, disease severity, and hospital length of stay are increased in COVID-19 patients with hepatopancreatic injury.

Graphical Abstract