bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANAJEMEN PENDIDIKAN ADAB DI PESANTREN TQH AL-HASYIMI TENGGULUN SOLOKURO LAMONGAN
Authors: Shafwan Muhammad Hambal , Hasna Hana Nadiatul 
Published: December 2024

This research aims to discuss how to manage adab education at the TQH al-Hasyimi Tenggulun Solokuro Lamongan Islamic Boarding School. This research is qualitative research with a case study approach, which means this research was conducted in a natural context to understand the phenomena that occur. The methods used include various techniques to carry out in-depth interpretation of the phenomenon. The results of this research explain that adab education at the TQH al-Hasyimi Islamic boarding school uses the book "at-Tibyan fi adab Hamalah al-Qur'an" as a guide. Implementation of learning of the book "al-Tibyân fî Âdâb Hamalah al-Qur'ân" at the Tahfidz Qur'an-Hadith al-Hasyimi Islamic Boarding School, with a management process that includes planning, organizing, actualling and supervision (controlling), requires time that is not instant and a continuous process. In practice, students are expected to be able to apply the etiquette taught in the book, such as: (1) Cleaning the Heart: Protecting the heart from despicable qualities and always trying to gain the approval of Allah SWT; (2) Polite Appearance: Ensure a neat and polite appearance when participating in learning activities; (3) Consistency of deposit times: Prioritize deposit times in the morning to repeat memorization with discipline; (4) Getting used to night Qira'ah: Performing tadarus and night prayers regularly to increase spirituality and understanding of the Koran.
Penelitian ini bertujuan untuk membahas bagaimana manajemen pendidikan adab di Pesantren TQH al-Hasyimi Tenggulun Solokuro Lamongan. Penelitian ini merupakan penelitian kualitatif dengan pendekatan studi kasus, yang berarti penelitian ini dilakukan dalam konteks alami untuk memahami fenomena yang terjadi. Metode yang digunakan mencakup berbagai teknik untuk melakukan interpretasi secara mendalam terhadap fenomena tersebut. Hasil penelitian ini menjelaskan bahwa Pendidikan adab di pesantren TQH al-Hasyimi menggunakan panduan kitab “at-Tibyan fi adab Hamalah al-Qur’an”. Pelaksanaan pembelajaran kitab “al-Tibyân fî Âdâb Hamalah al-Qur’ân” di Pesantren Tahfidz Qur’an-Hadits al-Hasyimi, dengan proses pengelolaan yang mencakup perencanaan (planning), pengorganisasian (organizing), pelaksanaan (actualling), dan pengawasan (controlling), memerlukan waktu yang tidak instan dan proses yang berkelanjutan. Dalam praktiknya, santri diharapkan dapat menerapkan adab-adab yang diajarkan dalam kitab tersebut, seperti: (1) Membersihkan Hati: Menjaga hati dari sifat-sifat tercela dan selalu berusaha mendapatkan ridha Allah SWT; (2) Berpenampilan Sopan: Memastikan penampilan yang rapi dan sopan saat mengikuti kegiatan pembelajaran; (3) Konsistensi Waktu Setoran: Mengutamakan waktu setoran di pagi hari untuk mengulang hafalan dengan disiplin; (4) Membiasakan Qira’ah Malam: Melakukan tadarus dan shalat malam secara rutin untuk meningkatkan spiritualitas dan pemahaman al-Qur’an.
Talveen liittyviä tunteita saariston arjessa – kirjeitä ja päiväkirjoja jäiden keskeltä
Authors: Haanpää Riina , Seesmeri Laura 
Published: December 2024

Tarkastelemme artikkelissamme kahden aikakauden ja saaristopaikkakunnan asukkaiden talveen ja erityisesti jäihin liittyviä tunteita ja vaikutuksia arkeen. Kysymme, mitä yhteneväisyyksiä ja eroja jääolosuhteet tuovat tutkimiemme kahden saaristolaisen elämään. Aineistoina käytämme Porin Reposaaressa vuosina 1897–1953 eläneen Urho Saralehdon päiväkirjoja sekä eteläisessä Nauvossa Borstön saarella vuosina 1917–1979 eläneen Erna Anderssonin kirjeitä ystävättärelleen.
Keskitymme esittelemään henkilökohtaisten biografisten lähteiden mahdollisuuksia syventyä affektiivisiin sisältöihin ja tutkimuskysymyksiin. Millaisia tunteita päiväkirjat ja kirjeet välittävät ja miten luemme näitä aineistoja affektiivisella otteella? Miten niissä paikantuvat talven sääolosuhteet ja jäätilanne? Millä tavoin saaristolaisuus hahmottuu jäistä ja omasta elämästä kirjoittamisen kautta?
Aineistomme osoittavat, että jää ja talven olosuhteet ovat vaikuttaneet tunteisiin; ei vain arjen käytäntöihin tai elinkeinon harjoittamiseen ja elannon saamiseen. Jäistä kertominen on ollut hyvin affektiivista ja se yhdistää erilaisia saaristopaikkakuntia eri aikoina. Jääolosuhteet ovat muovanneet tunnerekisteriä, jolla omaan lähiympäristöön on suhtauduttu. Sille on asetettu toiveita ja sitä on kiitetty tai pelätty. Jääolosuhteet ovat myös muovanneet sosiaalista elämää, sillä jäätilanne on voinut eristää tai se on voinut erityisesti helpottaa etenkin lasten ja naisten liikkumista saaristossa. Jää on näin tullut osaksi merkityksellistä ympäristösuhdetta ja on olennainen osa erilaisia saaristolaisuuksia. Jään voidaan tulkita olevan tärkeä yhdistävä tekijä saaristolaisuuden affektiivisuudessa ja kokemuksellisuudessa.
Morphological features of white adipose tissue in rats with different levels of energy metabolism in visceral obesity
Authors: Yanko R. V. , Safonov S. L. , Levashov M. I. 
Published: December 2024

Histomorphological changes of visceral white adipose tissue in obesity as a function of the level of energy metabolism in the body have not been sufficiently studied. The aim of this study was to investigate and compare the structural changes of visceral white adipose tissue in rats with different metabolic levels and severe visceral obesity. The study was carried out on male Wistar rats aged 3 months at the start of the experiment. Control animals received standard diet. Experimental rats were fed a high calorie diet for 12 weeks. At the end of the experiment, rats from both the control and experimental groups were divided into low and high level of energy metabolism depending on the intensity of total oxygen consumption. Histological preparations of visceral white adipose tissue were prepared according to the standard method. Histomorphometry was performed on digital images using the “Image J 1.34p” computer program. Biochemical methods were used to determine the concentration of triglycerides, lipids and cholesterol in blood serum. The method of multifrequency bioimpedance was used to assess the biophysical properties of visceral white adipose tissue. The data obtained were processed by methods of variational statistics using one-way analysis of variance. It was shown that long-term use of a high-calorie diet led to the development of visceral obesity, which was manifested by a significant increase in the weight of visceral fat and an increase in the concentration of indicators of lipid metabolism in blood serum. It was found that a high-calorie diet altered the morphological structure of the rat’s visceral white adipose tissue, leading to adipocyte hypertrophy, reduced blood volume and increased the amount of connective tissue in it. The bioelectrical properties of the visceral white adipose tissue changed, as evidenced by an increase in its electrical impedance and a decrease in its frequency dispersion coefficient. The intensity of structural, biochemical and biophysical changes in the visceral white adipose tissue was more pronounced in rats with low level of energy metabolism and depended on the degree of obesity. The results obtained are important for practical medicine in the development of new effective methods for the prevention and treatment of obesity in patients according to level of energy metabolism.
Impact of gamma-aminobutyric acid receptors modulators on renal and liver functional, molecular and histological characteristics in white male mice
Authors: Al-Azzawie A. F. , Ajeel M. A. , Al-Bayti A. A. H. 
Published: December 2024

The gamma-aminobutyric acid (GABA) receptors are considered the main receptors that inhibit neurotransmitters in the mammalian brain, and they have been proven to exist in non-neuronal cells. The study's purpose is to determine the impact of GABA modulation on renal and liver functions and molecular and histological characteristics using different doses of lorazepam. Lorazepam, one of the benzodiazepine drugs known for its modulatory effect on GABA receptors, has been used as a modulator to determine the impact of GABA modulation on renal and liver functions and molecular and histological characteristics in 30 albino male mice, out of which 21 were divided into 3 groups. Each group were treated with different dose of lorazepam (1 mg/kg, 2 mg/kg and 3 mg/kg body weight respectively). The rest 9 of animals were considered as a control group. Histological and functional parameters were studied in kidney and liver functional states to evaluate the impact of GAPA modulation using lorazepam. Total genomic DNA was extracted from liver, brain, kidney and blood and random amplification polymorphic DNA (RAPD) technique were used to detect the molecular impact of GABA modulation on the genomic DNA. The data were analyzed using SPSS Version 20.0 (SPSS Inc.), with means and standard deviations (SD) calculated for quantitative variables, and ANOVA applied for comparing group means. Functional parameters (blood urea, creatinine, GOT, GPT, GGT) and histopathological examination showed a significant change in treated groups compared to the control group. In both the liver and kidneys of mice, with increasing doses of lorazepam, there was an increase in the severity of congestive phenomena in blood vessels with the appearance of hemorrhages, signs of inflammation, and cell degeneration and necrosis. The molecular investigation indicated substantial changes in RAPD profiles of treated groups, with normal bands disappearing and novel bands appearing in contrast to the control group. The RAPD profiles of the treated and control samples revealed 432 bands, with 109 as control bands, 167 (loss of normal bands and emergence of novel bands) as polymorphic bands, and 156 as homomorphic bands. It is concluded that GABA modulation by lorazepam increases the functional and histopathological alterations, producing variations in the genomic DNA.
HETEROPOLYSACCHARIDE OF KGM-XANTHAN HYDROGELS FOR THE REMOVAL OF BACTERIA IN A WOUND MODEL
Authors: Shahbuddin Munira , Abdul Raus Raha , Yusof Aqilah , Mahamad Siti Syazwani 
Published: December 2024

This project focused on the development of polysaccharides hydrogels from Konjac Glucomannan (KGM) and Xanthan gum in removing the bacterial load on wound. This new therapy design is due to the traditional wound care methods using antibiotic and normal hydrogel cannot adequately treat biofilm infected wounds to healing process. For the treatment of bacterial infected wound, bacterial removal need to be done physically and manually by debridement, which is very painful and require the use of general anesthesia. Therefore, to reduce the formation of slough and necrotic tissue by the formation of bacterial biofilm, there is a need of specific hydrogels that will able to remove bacterial from the wounded site so it will prevent further infection and enhance the healing process. This study focused on the design and optimization of polysaccharide based hydrogels for the wound treatment. Polysaccharide based hydrogels from Konjac Glucomannan (KGM) and Xanthan gum were developed at different ratio to optimize the physical and chemical properties of the hydrogel that relate to the effectiveness of bacterial removal. Film casting technique was used in the development of the hydrogel film. Konjac Glucomannan (KGM) and Xanthan gum were selected because of their natural polymers properties which are non – toxic, biocompatible and safe to be used. The hydrogels were tested in vitro for bacterial removal efficacy, using E.coli species colonies cultured on a gel inside a petri dish to represent the condition of bacteria infested wound bed. Hydrogel with 50 : 50 % composition blend of KGM-XG was found to be the most effective in the removal of E.coli colonies with 13x103 CFU/mL at 95% water content. Morphological studies of hydrogels showed flat interfacial morphologies, except the sample with 100% of Xanthan without KGM. The results present in this study suggested that the biological activities and adhesion of the hydrogels were not controlled only by the chemical structure but also the composition of compound and the amount of water present in the hydrogels.
Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology
Authors: Perie Luce , Stippa Selina , Saffer Christoph , Hartmann Andrea , Mörgelin Mathias , Zipfel Svante L. H. , Figge Marc Thilo , Wiech Thorsten , Skerka Christine , Zipfel Peter F. 
Published: December 2024

IntroductionFHR1 is a multifunctional human plasma protein with three C-terminal domains, namely short consensus repeats (SCR) 3–5, showing 98% sequence-identity with the complement inhibitor Factor H. We show that FHR1 uses all three C-terminal SCR to make surface contact. The conserved C-terminal regions of FHR1 and Factor H are altered in patients with atypical-hemolytic-uremic-syndrome. Therefore, we compared FHR1 isoforms with sequence-variations in SCR3, and pathogenic mutants with sequence variations in SCR5.MethodsFHR1 binding to apoptotic cells was evaluated EM and fluorescent microscopy and in kidney biopsies. FHR1 and Factor H variants and mutants were generated and expressed. The variants and mutant proteins were tested in binding studies to C3b , C3d and heparin, in hemolytic assays and for the induction of inflammatory cytokines. The action profiles of FHR1 and Factor H were calculated and compared.ResultsFunctional data revealed that residues YVQ vs HLE in SCR3 and LA vs SV in SCR5 altered ligand binding and surface interaction, influenced target recognition and complement control. Amino-acid-sequence variations in SCR3 influenced FHR1 contact with surface constituents, such as glycosaminoglycans. By contrast, SCR5, the most C-terminal domain, was more relevant for C3b/C3d contact. Notably, wild-type FHR1LA selected C3d, while pathogenic aHUS-associated alterations FHR1SV selected C3b. In consequence mutant FHR1SV altered fined-tuned FHR1-directed effector functions while pathogenic Factor HLA modified C3-convertase control.DiscussionThis influences timing of complement control and inflammatory effector actions at modified self-surfaces. Pathogenic FHR1SV, directed to C3b-decorated targets, adds inflammatory activity at a time when C3-convertase control is appropriate and conversely, mutant Factor HLA adds C3-convertase control at C3d-coated surfaces when inflammatory effector functions are favorable. Further, our computational modeling approach confirms such distinct effects of FHR1 monomers and dimers as compared to flexible Factor H. These effects may explain inappropriate timing of complement regulation and inflammation of the aHUS-derived mutant proteins FHR1SV and Factor HLA.
THE UTILIZING OF DIGITAL CROSSWORD PUZZLE GAME TO ENHANCE STUDENTS’ VOCABULARY MASTERY
Authors: Madaniyah Nurul Asyifah , Anita Anita , Oktaviana Fadilla 
Published: December 2024

This research investigated the implementation of digital crossword puzzle games to enhance students’ vocabulary mastery and to know the enhancement on students’ vocabulary mastery by using digital crossword puzzle games. This research used a quantitative approach with the type of pre-experiment one group pre-test post-test. Data collection was carried out by conducting pretest, posttest, and observation. The participants in this research were 35 students from class X5 of SMAN 3 Kota Serang. Before the treatment was carried out, students were given a pretest first then on the next day students were given treatment using a digital crossword puzzle game and at the end, students were given a posttest to determine the final score of students after being given treatment. The pretest and posttest questions used include the types of questions, which are 10 questions cloze test, 5 questions gap filling the verbs, 5 questions matching words and 10 questions gap filling test (sentences completion).The results showed that based on observations of teacher and student activities in the implementation of digital crossword puzzle games conducted by English teacher at Sman 3 Kota Serang, there are 10 aspect indicators for observation of teacher and student activity assessments, the results of the observations showed that both teacher and students have shown an improvement in the quality of learning, this can be seen from the results of observations of all indicators for teacher assessments got a good category with a percentage of 72% and 78%. While for student activity assessments got good and excellent category with percentage of 80% and 90%. In addition, the value of t count was greater than t table, namely 5.72 > 1.69, and sig 0.00 < 0.05, then H0 is rejected and H1 is accepted.
LITERATURA POR APROPRIAÇÃO E CULTURA DIGITAL NO MANIFESTO COPISTA, DE MESSIAS BOTNARO E JOANIM PEPPERONI, PHD
Authors: Cei Santos Vitor 
Published: December 2024

Resenha da plaquete digital Manifesto Copista, de Messias Botnaro e Joanim Pepperoni, PhD, pseudônimos ou avatares de escritores que permanecem no anonimato.
ENTRELACES DA TERRA E DA CARNE:
Authors: Bernardes de Souza Júnior Carlos Roberto 
Published: December 2024

A fenomenologia merleau-pontiana possui significativas contribuições para a reflexão acerca das questões socioambientais, especialmente em suas investigações sobre a natureza, a Terra, a carne e o quiasma. Cada qual em sua virtualidade, esses conceitos colaboram para elucidar as dinâmicas existenciais dos mundos mais-que-humanos. Tais concepções foram recentemente retomadas pelos teóricos da ecofenomenologia e possibilitam pontos de interação para a expansão da perspectiva geográfico-fenomenológica de Dardel. Desse modo, esse ensaio objetiva perscrutar a potencialidade da análise filosófica da natureza composta pelas obras tardias de Merleau-Ponty e de suas revisões contemporâneas para a compreensão da realidade geográfica. Para tanto, realiza-se uma análise geográfica e filosófica que articula o pensamento merleau-pontiano com as (re)interpretações ecofenomenológicas. Entende-se que a Terra é o arco originário da experiência que garante a ontogênese carnal dos fenômenos como entrelaces existenciais. Nesse sentido, é por meio dela que a realidade geográfica pode emergir como potencialidade experiencial mais-que-humana por meio da qual há relações de intercorporeidade e intersubjetividade. Tomada em seu nexo primacial, a condição carnal da Terra é uma dimensão de unicidade e de partilha de mundos que pluralizam a experiência geográfica, com especial foco para a dinâmica transpessoal e outra-que-humana dos afetos que nela são partilhados em reciprocidade e reversibilidade. Conclui-se que outras formas de ver, sentir e ser-da-e-na-Terra podem colaborar para minar o especismo humano que está entre os baluartes das fissuras ecológicas contemporâneas.
Palavras-chave: Carnalidade; Quiasma; Natureza; Mundos mais-que-humanos; Geografia Humanista.
Fatores de risco associados à depressão pós-parto: revisão integrativa
Authors: Aguiar Priscilla Ferraz Alves , Sa Luiz Vitor Marques de Abreu , Triaca Matheus de Sousa , Alencar Keyla Stefany Araújo de , Barreto Adriana Edwirgens de Albuquerque 
Published: December 2024

Objetivo: Investigar na literatura os fatores de risco associados ao desenvolvimento da DPP. Método: Revisão Integrativa da Literatura baseada na pergunta de investigação “Quais os fatores de risco associados à DPP?”. O levantamento eletrônico ocorreU nas bases de dados LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde) e Pubmed (National Library of Medicine; National Institutes of Health). A busca dos estudos foi realizada utilizando-se as palavras-chave registradas nos Descritores em Ciências da Saúde (DeCs) da seguinte forma: “Depressão pós-parto”, “Puerpério”, “Fatores de risco”, “Saúde mental”. Resultados: Foram selecionados 6 estudos para serem discutidos nesta revisão integrativa. Todos os estudos avaliaram os fatores de risco em mulheres pós gestação. Discussão: Mulheres jovens com baixa escolaridade, experiência em traumas físicos ou sexuais, gravidez não intencional, modo de parto operatório ou histórico de transtornos depressivos e ansiosos ou síndrome pré-menstrual parecem estar em risco de transtornos depressivos ou ansiosos incidentes e recorrentes durante o período periparto. Os preditores independentes mais fortes de DPP foram exposição a estressores sociais extremos, como testemunhar um crime violento/perigo de ser morta. Considerações finais: A identificação precoce do risco potencial para a DPP deve incluir a avaliação da personalidade, histórico psiquiátrico, avaliação sociodemográfica, eventos de vida recentes e fatores obstétricos. Os principais fatores de risco associados com a DPP foram mulheres jovens com baixa escolaridade, experiência em traumas físicos ou sexuais, gravidez não intencional, modo de parto operatório ou histórico de transtornos depressivos e ansiosos ou síndrome pré-menstrual parecem estar em risco de transtornos depressivos ou ansiosos.
Relação entre disbiose intestinal e transtorno do déficit de atenção com hiperatividade: uma revisão integrativa
Authors: Carretta Lucca Tamara Alves , Teixeira Pedro Rodrigues , Faria Lucas Copolillo , Valbão Nicolas Pimenta , Oliveira Vanessa Cristina Rodrigues de , Duarte Neto Caio , Duarte Simone Karla Apolonio 
Published: December 2024

O transtorno de déficit de atenção com hiperatividade (TDAH) é um transtorno do neurodesenvolvimento que vem apresentando aumento no número de diagnósticos e visibilidade pública nos dias atuais; com prevalência de 7,8% em crianças e adolescentes brasileiros. Devido ao crescente interesse científico acerca da relação da saúde entérica com o tema, o presente estudo tem por objetivo principal identificar a possível relação entre a disbiose intestinal e o TDAH e como objetivos secundários, avaliar se existe algum padrão de composição da microbiota e a frequência da disbiose. Trata-se de uma revisão integrativa, para a qual foram utilizadas as bases de dados PubMed, Biblioteca Virtual em Saúde e SciELO, com a estratégia de busca “(dysbiosis OR microbiota) AND ‘Attention Deficit Disorder with Hyperactivity’", sendo encontrados 124 artigos, dos quais 6 eram duplicados, 42 eram revisões, 64 foram eliminados por leitura do título, ou resumo ou íntegra, restando 12 artigos selecionados para compor esta revisão. Apesar da heterogeneidade dos estudos em relação à etnia, faixa etária e tamanho das amostras analisadas, os resultados encontrados, embora ainda limitados, são promissores e destacam a relevância de aprofundar as investigações sobre a complexa interconexão entre o eixo intestino-cérebro e o TDAH.
Principais doenças e agravos de interesse na saúde pública por regiões brasileiras
Authors: Regis Thiago Gurgel , Oliveira Ana Carolina Alves de , Matoso Ana Luiza Cardoso Pereira , Dantas Isaac de Moura , Nogueira João Lucas Filgueira , Alves Liliany Mirelly Bezerra , Henriques Renata Paula de Sousa Azevedo , Silva Filho Ronaldo Adão da , Barbosa Elane da Silva 
Published: December 2024

Objetivo: apresentar as principais causas de morbimortalidade no Brasil, a partir da sua distribuição por regiões. Métodos: estudo epidemiológico do tipo descritivo, com coleta de dados do DATASUS. A população selecionada foi subdividida de acordo com as regiões brasileiras, sendo posteriormente analisada sob os filtros do CID-10 de morbidade e de mortalidade, a partir dos quais foram quantificados os cinco agravos mais prevalentes regionalmente. Resultados: identificaram-se os principais problemas de saúde de cada região brasileira, os quais variam em cada região, e como esses são influenciados por fatores como clima, investimento em saúde e renda média populacional. Conclusão: constata-se que as políticas e estratégias devem ser adaptadas para atender às necessidades específicas de cada localidade e a compreensão dessas diferenças é essencial para o desenvolvimento de intervenções mais eficazes.