bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of intraoperative digital scintigraphy in radioguided parathyroidectomy
Authors: Creighton Erin Weatherford , Dunlap Quinn , Peckham Merry M. , Elms Christopher , King Deanne , Stack Brendan C. 
Published: June 2021

AbstractBackgroundIntraoperative scintigraphy (IoS) has been proposed as a tool for real‐time intraoperative decision‐making regarding parathyroid adenoma localization and confirmation of excision.MethodsRetrospective review of patients who underwent minimally invasive parathyroidectomies with scintigraphy performed intraoperatively. Preoperative neck ultrasound, 4D computed tomography, as well as intraoperative parathyroid hormone (IOPTH) and gamma probe measurements were conducted per standard practice. IoS images were obtained prior to and following parathyroid excision. Cases were reviewed to determine accuracy of IoS for localizing parathyroid pathology and confirming successful excision.ResultsFifty‐six cases met the inclusion criteria. Twenty‐nine patients (51.8%) showed confirmation of excision of an abnormal gland on post‐excision IoS. There were no significant differences in IOPTH reduction and postoperative laboratory values between patients with IoS‐identified resolution and those without IoS‐identified resolution.ConclusionsWith low accuracy in correctly localizing abnormal glands and confirming their excision, there is no appreciable benefit of IoS at this time.
Consensus of free flap complications: Using a nomenclature paradigm in microvascular head and neck reconstruction
Authors: Mady Leila J. , Poonia Seerat K. , Baddour Khalil , Snyder Vusala , Kurukulasuriya Chareeni , Frost Ariel S. , Cannady Steven B. , Chinn Steven B. , Fancy Tanya , Futran Neal , Hanasono Matthew M. , Lewis Carol M. , Miles Brett A. , Patel Urjeet , Richmon Jeremy D. , Wax Mark K. , Yu Peirong , Solari Mario G. , Sridharan Shaum 
Published: June 2021

AbstractBackgroundWe aim to define a set of terms for common free flap complications with evidence‐based descriptions.MethodsClinical consensus surveys were conducted among a panel of head and neck/reconstructive surgeons (N = 11). A content validity index for relevancy and clarity for each item was computed and adjusted for chance agreement (modified kappa, K). Items with K < 0.74 for relevancy (i.e., ratings of “good” or “fair”) were eliminated.ResultsFive out of nineteen terms scored K < 0.74. Eliminated terms included “vascular compromise”; “cellulitis”; “surgical site abscess”; “malocclusion”; and “non‐ or mal‐union.” Terms that achieved consensus were “total/partial free flap failure”; “free flap takeback”; “arterial thrombosis”; “venous thrombosis”; “revision of microvascular anastomosis”; “fistula”; “wound dehiscence”; “hematoma”; “seroma”; “partial skin graft failure”; “total skin graft failure”; “exposed hardware or bone”; and “hardware failure.”ConclusionStandardized reporting would encourage multi‐institutional research collaboration, larger scale quality improvement initiatives, the ability to set risk‐adjusted benchmarks, and enhance education and communication.
Detailed streamflow data for understanding hydrologic responses in the Logan River Observatory
Authors: Neilson Bethany T. , Tennant Hyrum , Strong Patrick A. , Horsburgh Jeffery S. 
Published: June 2021

AbstractThe Logan River watershed, located in Northern Utah, USA, consists of a relatively pristine, mountainous area that drains to a lower elevation, valley area influenced by both urban development and agriculture. The Logan River Observatory has been collecting aquatic (streamflow and water quality) and climate data throughout the Logan River watershed since 2014. While streamflow measurements are commonly made at the outlets of research watersheds, the Logan River watershed consists of diverse hydrologic, topographic, and geologic settings that require a detailed understanding of streamflow variability over time at many locations. Here, we illustrate: (a) the importance of collecting streamflow time series throughout complex watersheds, and (b) how simple flow balances can provide much needed hydrologic insight into the locations and timing of gains and losses over reaches to guide future investigations.
Associations between maternal and environmental exposures on atopic disease in the offspring of mothers with asthma
Authors: Ali Zarqa , Jemec Gregor B.E. , Ulrik Charlotte Suppli 
Published: June 2021

AbstractBackground and ObjectiveAvailable data on the impact of perinatal and environmental factors on atopic diseases in the offspring are sparse and conflicting. We, therefore, investigated the impact of these factors on the risk of atopic diseases in the offspring of women with asthma.MethodsPregnant women referred to give birth at Copenhagen University Hospital‐Hvidovre, Denmark, have since 2007 been invited to participate in the Management of Asthma during Pregnancy program. Women with diagnosed asthma, currently prescribed asthma medication, first visit to the respiratory out‐patient clinic within the first 18 weeks of pregnancy that completed an online questionnaire about atopic diseases in their child were included in the current study.ResultsFive hundred and seventy‐one pregnancies were included. Among the off‐spring, 113 children (21%) had doctor‐diagnosed asthma, 178 (31%) atopic dermatitis (AD), and 55 (32%) both AD and doctor‐diagnosed asthma. AD in the offspring was associated with having a dog at home (odds ratio [OR], 2.56; 95% confidence interval [CI], [1.40–4.67], p = .002), whereas having a cat at home was associated with a higher risk of asthma in the offspring (OR, 2.16; 95% CI, [1.14–4.11], p = .02). The associations remained significant after adjusting for maternal age, smoking status, allergy, treatment with inhaled corticosteroids, forced expiratory volume in 1 s less than 80% predicted, uncontrolled asthma, and history of pre‐pregnancy asthma exacerbations. No association was found between gestational weight gain (GWG) in first trimester and total GWG and atopic disease in the offspring.ConclusionHaving pets at home is associated with AD and asthma in the offspring of mothers with asthma.
CircZNF124 regulates cell proliferation, leucine uptake, migration and invasion by miR‐199b‐5p/SLC7A5 pathway in endometrial cancer
Authors: Shu Liuping , Peng Yan , Zhong Liyan , Feng Xi , Qiao Lifu , Yi Yi 
Published: June 2021

AbstractBackgroundRecent studies have revealed that circular RNA participates in endometrial carcinoma (EC) progression. Here we investigated the role of circRNA zinc finger protein 124 (circZNF124) in EC genesis and underlying mechanism.MethodsThe expression levels of circZNF124, microRNA‐199b‐5p (miR‐199b‐5p) and solute carrier family 7 member 5 (SLC7A5) were detected by quantitative real‐time polymerase chain reaction. The expression of SLC7A5 and other indicated marker proteins was determined by western blot analysis. For functional assay, cell proliferation, leucine uptake and metastasis were investigated by total cell number, cell counting kit‐8, cell colony formation, leucine uptake or transwell assay. The interaction between miR‐199b‐5p and circZNF124 or SLC7A5 was predicted by starbase online database, and identified by mechanism assays. The impact of circZNF124 absence on tumor growth in vivo was revealed by xenograft mouse model assay. Immunohistochemistry assay was implemented to detect the positive expression rate of nuclear proliferation marker (Ki67).ResultsCircZNF124 and SLC7A5 expression were significantly increased, while miR‐199b‐5p was decreased in EC tissues and cells compared with normal endometrial tissues or cells. CircZNF124 expression was closely associated with EC severity and lymph node metastasis. Additionally, circZNF124 depletion repressed cell proliferation, leucine uptake, migration and invasion in both HEC1A and Ishikawa cells. CircZNF124 regulated SLC7A5 expression by binding to miR‐199b‐5p. MiR‐199b‐5p inhibitors or SLC7A5 overexpression attenuated circZNF124 silencing‐mediated EC malignant progression. Furthermore, SLC7A5 absence inhibited tumor growth in vivo.ConclusionCircZNF124 depletion inhibited EC cell malignancy by miR‐199b‐5p/SLC7A5 pathway, which demonstrated that circZNF124 had the potential as a therapeutic target for EC.
Childhood ovarian nonseminomatous germ cell tumors: A highly curable disease with few long‐term treatment‐related toxicities—Results of the French TGM95 study
Authors: Pavone Rossana , Pacquement Hélène , Pasquet Marlène , Sudour‐Bonnange Hélène , Hameury Fédéric , Sarnacki Sabine , Chastagner Pascal , Faure‐Conter Cécile , Poirée Marilyne , Taque Sophie , Patte Catherine , Fresneau Brice 
Published: June 2021

AbstractWe report survival and late effects analysis of TGM95 study for childhood (≤18 years) ovarian nonseminomatous germ cell tumors (NS‐GCT). Patients with localized tumors (FIGO‐stage IA) had no adjuvant treatment (low‐risk, LR). Patients with advanced‐stage received 3‐5 VBP (vinblastin‐bleomycin‐cisplatin) in intermediate‐risk group (IR: FIGO‐stage IC‐II‐III and AFP < 15 000 ng/mL) or 4‐6 VIP (etoposide‐ifosfamide‐cisplatin) in high‐risk group (HiR: metastatic or AFP ≥ 15 000 ng/mL). Seventy‐seven patients were included (median age = 12 years): 14 LR (13 FIGO‐stage IA, 1 retrospectively IC), 26 IR (12 IC, 12 II‐III, 2 not‐available) and 37 HiR (2 IA with AFP ≥ 15 000 ng/mL, 27 II‐III, 8 IV). After a median follow‐up of 13.4 years, 12 events (eight relapses) and six deaths (two GCT‐related, two due to acute myeloid leukemia and two noncancer related) occurred. All relapses (6 LR, 1 IR) occurred within 2 years. Four contralateral mature teratomas were observed within 8 years. Five‐year EFS and OS were 88.2% (95%CI = 79‐94%) and 94.6% (95%CI = 87‐98%). Seven patients (9%) had bilateral gonadectomy. Among 51 survivors at 2 years aged >15 years (median = 26 years) with remaining ovarian tissue, all had developed spontaneous puberty and 21 (41%) had at least one pregnancy (including two with infertility treatment). Among 69 patients treated with platinum‐based chemotherapy, chronic‐kidney‐disease was diagnosed in four patients (three after VIP) and significant ototoxicity occurred in three (all grade‐2). Childhood ovarian NS‐GCTs have an excellent prognosis with few late effects. The low‐intensive etoposide‐free VBP regimen could be an alternative in children with IR disease especially in cases of tumor rupture. The risk of contralateral mature teratoma needs regular monitoring of the remaining ovary.
A case of adenocarcinoma of the rete testis with durable response to cisplatin‐based chemotherapy
Authors: Owa Shunsuke , Sasaki Takeshi , Uchida Katsunori , Watanabe Susumu , Kato Momoko , Sugino Yusuke , Kato Manabu , Masui Satoru , Nishikawa Kouhei , Yoshio Yuko , Kanda Hideki , Sugimura Yoshiki , Inoue Takahiro 
Published: June 2021

IntroductionAdenocarcinoma of the rete testis is a rare malignancy with a poor prognosis. We report a case of adenocarcinoma of the rete testis with a durable response to cisplatin‐based chemotherapy.Case presentationA 48‐year‐old man with Down syndrome (trisomy 21) presented with a 1‐month history of painless swelling of the left scrotum. The physical examination revealed a left testis with a hydrocele associated with a tumor and enlarged pelvic and para‐aortic lymph nodes. He underwent a radical orchiectomy. The specimen was diagnosed as adenocarcinoma of the rete testis. The patient received 7 cycles of chemotherapy (1 cycle of BEP and 6 cycles of EP) postoperatively. The metastatic lymph nodes were reduced in size for at least 12 months. Our patient with adenocarcinoma of the rete testis obtained an acceptable response to cisplatin‐based chemotherapy.ConclusionWe treated a patient with an adenocarcinoma of the rete testis who had an acceptable response to platinum‐based chemotherapy.
Investigating the effect of multi‐coated hydrogel layer on characteristics of electrospun PCL membrane coated with gelatin/silver nanoparticles for wound dressing application
Authors: Nguyen Tien Ngoc‐Thuy , Do Thien Bui‐Thuan , Ho Minh Hieu , Tran Nam Minh‐Phuong , Dang Nhi Ngoc‐Thao , Do Thai Minh , Nguyen Hoai Thi‐Thu , Phan Thang Bach , Tran Quyen Ngoc , Van Vo Toi , Nguyen Hiep Thi 
Published: June 2021

AbstractIn this study, the effect of coated hydrogel layer on characteristics of the whole gelatin/silver nanoparticles multi‐coated polycaprolactone membrane (PCLGelAg) was investigated through systematic and typical wound dressing characterizations to select the optimal number of layers for practical applications. Scanning electron microscopy, free swell absorptive capacity and tensile test in both wet and dry conditions were conducted to characterize all fabricated membranes of six coating times. In vitro cytotoxicity and agar diffusion evaluation were also carried out to assess the biocompatibility and antibacterial activity of the membranes. The findings illustrated that as the coated layers increase, the absorptive capacity, and degradation rate were higher, the membranes were stiffer in dry state while the tensile strength in wet state, elongation, and cell viability were significantly decreased. PCLGelAg3 was chosen to be the best fit for wound healing since it maintained quite sufficient maximum buffer uptake, elasticity, cell viability along with inducing abnormalities in bacterial morphology and preventing biofilm formation.
Examining contextual influences on the service needs of homeless and unstably housed domestic violence survivors
Authors: Chiaramonte Danielle , Clements Kathryn A.V. , López‐Zerón Gabriela , Ayeni Oyesola Oluwafunmilayo , Farero Adam M. , Ma Wenjuan , Sullivan Cris M. 
Published: June 2021

AbstractDomestic violence (DV) is a leading cause of homelessness for women, yet many DV agencies are just beginning to focus on helping clients stabilize their housing situations. The purpose of this study was to better understand the contexts and service needs of unstably housed and homeless DV survivors, to promote more efficient and successful service matching from DV agencies. We examined whether DV survivors could be grouped by particular features, histories, and contextual factors, and how these group differences impacted what they needed from DV agencies. The sample included 406 homeless and unstably housed DV survivors who had recently sought DV services. Latent class analysis supported the identification of four distinct classes: (1) highest disadvantages service seeker, (2) moderate disadvantages—criminal legal system service seeker, (3) moderate disadvantages service seeker, and (4) lower disadvantages service seeker. Additionally, we were able to profile each class, and test the types of services survivors in each class needed from agencies.
The impact of public policies on acculturation: A mixed‐method study of Latinx immigrants' experiences in four US states
Authors: Buckingham Sara L. , Angulo Angela 
Published: June 2021

AbstractAimsThis study sought to understand the impact of public policies on Latinx immigrants' acculturation.MethodsFour hundred thirty‐eight first generation Latinx immigrants completed survey measures and a subset (n = 73) participated in 12 focus groups across four US states with distinct immigration‐related policies: Arizona, New Mexico, Maryland, and Virginia.ResultsLatinx immigrants living in states with more restrictive immigration‐related public policies were less likely to make cultural changes in the ways they desired. Policies impacted acculturation directly by requiring and restricting certain cultural expressions, and indirectly through cultivating the community's climate. Multiple factors appeared to shape policies' influences on acculturation, including confusion from swift policy changes, inconsistent policy implementation, competing policies at divergent ecological levels, and individuals' relative privilege from intersecting personal characteristics.ConclusionsMore inclusive and supportive immigration‐related policies may improve Latinx immigrants' abilities to acculturate in their preferred ways.
Extracellular vesicles carry SARS‐CoV‐2 spike protein and serve as decoys for neutralizing antibodies
Authors: Troyer Zach , Alhusaini Najwa , Tabler Caroline O. , Sweet Thomas , de Carvalho Karina Inacio Ladislau , Schlatzer Daniela M. , Carias Lenore , King Christopher L. , Matreyek Kenneth , Tilton John C. 
Published: June 2021

AbstractIn late 2019, a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) emerged in Wuhan, China. SARS‐CoV‐2 and the disease it causes, coronavirus disease 2019 (COVID‐19), spread rapidly and became a global pandemic in early 2020. SARS‐CoV‐2 spike protein is responsible for viral entry and binds to angiotensin converting enzyme 2 (ACE2) on host cells, making it a major target of the immune system – particularly neutralizing antibodies (nAbs) that are induced by infection or vaccines. Extracellular vesicles (EVs) are small membraned particles constitutively released by cells, including virally‐infected cells. EVs and viruses enclosed within lipid membranes share some characteristics: they are small, sub‐micron particles and they overlap in cellular biogenesis and egress routes. Given their shared characteristics, we hypothesized that EVs released from spike‐expressing cells could carry spike and serve as decoys for anti‐spike nAbs, promoting viral infection. Here, using mass spectrometry and nanoscale flow cytometry (NFC) approaches, we demonstrate that SARS‐CoV‐2 spike protein can be incorporated into EVs. Furthermore, we show that spike‐carrying EVs act as decoy targets for convalescent patient serum‐derived nAbs, reducing their effectiveness in blocking viral entry. These findings have important implications for the pathogenesis of SARS‐CoV‐2 infection in vivo and highlight the complex interplay between viruses, extracellular vesicles, and the immune system that occurs during viral infections.
B‐cell haematological malignancies and SARS‐CoV‐2 infection: Could immunological interventions influence the outcome?
Authors: Ochoa‐Grullón Juliana , Peña Cortijo Ascensión , Guevara‐Hoyer Kissy , Jiménez García Carlos , de la Fuente Eduardo , de la Peña Antonia Rodríguez , Fernández‐Arquero Miguel , González Fernández Ata , Sánchez‐Ramón Silvia 
Published: June 2021

AbstractB cell haematological malignancies (HMs) have been described as the worst cancer type for concomitant COVID‐19 in terms of mortality, with rates up to 65%. This risk factor for COVID‐19 cannot only be explained by comorbidities and advanced age of patients, but aggravated by secondary immunodeficiency (SID). We aimed at evaluating the impact of COVID‐19 on 86 HM patients with concomitant SID from a single centre. Only 14 HM patients of 86 (16.28%) patients suffered COVID‐19, with mortality rate of 7%. When we considered patients according to B‐cell defect only or multiple immune defect overlap (B‐T‐cell/NK cells/complement), patients with immune defect overlap presented 5.30‐fold higher risk of COVID‐19 than only B cell defect (95% CI, 1.67–17.0) (p = 0.004). Seven (50%) patients were on active IgRT; while five (36%) had received prior mucosal vaccines for respiratory infections. Our results show that modelling SID in HM may contribute to better prediction of infectious risk and to prompt more targeted and timely preventive therapies.
Synthesis, antioxidant, and antimicrobial activity of 3‐(1H‐indole‐3‐carbonyl)‐2H‐chromen‐2‐ones
Authors: Umar Basha Khadhar Navaz , Gnanamani Shanthi , Shanmugam Prakash , Venugopal Sujatha , Murthy Sangeetha , Ramasamy Balagurunathan 
Published: June 2021

AbstractA simple and convenient method for the one‐pot synthesis of 3‐(1H‐indole‐3‐carbonyl)‐2H‐chromen‐2‐one derivatives from the reaction of 3‐cyanoacetyl indole and salicylaldehyde in the presence of Na2CO3 in water: methanol (1:1) is described. Wider substrate scope, high yields, operational simplicity, and simple purification process make the protocol highly applicable in the synthesis of 3‐(1H‐indole‐3‐carbonyl)‐2H‐chromen‐2‐ones. For the first time, in vitro antioxidant and antimicrobial activity was studied. Compounds 5e, 7a, and 7b exhibits good radical scavenging ability against DPPH free radical. Compounds 7b, 5f, and 5g possess lower EC50 values than the Standards AA and BHA and thus proving their high reducing power. Compounds 5d and 5f show good antibacterial activity against gram‐positive bacteria (MRSA) while compounds 5c, 7a, and 7b exhibits good antibacterial activity against Bacillus sp. Compounds 5b and 5e show good antibacterial activity against gram negative bacterial strains (Escherichia coli, Klebsiella pneumoniae) and compounds 5g and 5h exhibits good antifungal activity against Candida albicans.
Nonsteroidal anti‐inflammatory drugs based new 1,2,3‐triazole derivatives: Their design, one‐pot synthesis and in vitro evaluation
Authors: Kuntala Naveen , Mareddy Jyoti , Telu Jhonsee Rani , Banothu Venkanna , Pal Sarbani , Anireddy Jaya Shree 
Published: June 2021

AbstractA series of novel and small molecules containing structural features of some well‐known nonsteroidal anti‐inflammatory drugs (NSAIDs) such as mefenamic acid or ibuprofen or naproxen and a heterocyclic moiety, for example, benzoxepine or quinoline were designed where a substituted 1,2,3‐triazole was used as a linker. These molecules were initially designed as potential antibacterial agents. Synthesis of these compounds was carried out using a Cu‐catalyzed azide‐alkyne cycloaddition (CuAAC) as the key step to construct the central 1,2,3‐triazole ring. The methodology involved regioselective and in situ azide formation from a dichloro derivative of heterocycle followed by click reaction with the appropriate alkyne containing the NSAID framework in the same pot. This one‐pot sequential reaction afforded 24 target compounds in good yields. To assess their antibacterial properties, all the synthesized compounds were tested against both Gram‐positive and Gram‐negative species bacterial strains. One compound was found to be effective against the Gram‐negative species P. aeruginosa. This compound also showed selective cytotoxicity against two cancer cell lines (COLO‐205 and HOP‐62) but no significant effect against noncancerous cell line (HEK293).