bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
Authors: Spiteri Alanna G. , Wishart Claire L. , Pamphlett Roger , Locatelli Giuseppe , King Nicholas J. C. 
Published: December 2021

AbstractIn neurological diseases, the actions of microglia, the resident myeloid cells of the CNS parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive immune-mediated pathology. However, defining the precise roles of each cell type has historically been impeded by the lack of discriminating markers and experimental systems capable of accurately identifying them. Our ability to distinguish microglia from monocytes in neuroinflammation has advanced with single-cell technologies, new markers and drugs that identify and deplete them, respectively. Nevertheless, the focus of individual studies on particular cell types, diseases or experimental approaches has limited our ability to connect phenotype and function more widely and across diverse CNS pathologies. Here, we critically review, tabulate and integrate the disease-specific functions and immune profiles of microglia and monocytes to provide a comprehensive atlas of myeloid responses in viral encephalitis, demyelination, neurodegeneration and ischemic injury. In emphasizing the differential roles of microglia and monocytes in the severe neuroinflammatory disease of viral encephalitis, we connect inflammatory pathways common to equally incapacitating diseases with less severe inflammation. We examine these findings in the context of human studies and highlight the benefits and inherent limitations of animal models that may impede or facilitate clinical translation. This enables us to highlight common and contrasting, non-redundant and often opposing roles of microglia and monocytes in disease that could be targeted therapeutically.
Analysis of the energy balance and CO2 flow under the influence of the seasonality of climatic elements in a mangrove ecosystem in Eastern Amazon
Authors: Freire Antonio Sérgio C. , Vitorino Maria Isabel , de Souza Adriano Marlisson L. , Germano Michell Fontenelle 
Published: December 2021

AbstractAn unprecedented study was carried out in a mangrove ecosystem in the northeastern coast of the Brazilian Amazon to understand the behavior of climatic elements in a year with the occurrence of El Niño (2015), associated with the seasonal function source/sink of CO2 by the ecosystem. Global radiation (Rg), net radiation (Rn), temperature, relative humidity, precipitation, horizontal wind speed and direction, as well as turbulent flows of sensible heat (H), latent heat (LE), and carbon (f_CO2) were recorded using eddy covariance, a system for studying turbulent flows of heat and gases in the atmosphere. We observed a drastic reduction in rainfall volumes, which accounts for 63.7% of the expected total according to the region’s climatology. Regarding f_ CO2, the highest values of photosynthesis, autotrophic, and heterotrophic respiration of the ecosystem occurred in the wet season due to precipitation, ideal photosynthetically active radiation, lower soil salinity, and higher NDVI of the ecosystem. In the 2nd semester of the year, we observed that the decrease in cloudiness, causing a higher radiation supply in the forest canopy, accompanied by a reduction in precipitation and an increase in the value of H and soil salinity, favored the increase of foliar abscission by the dominant genus Rhizophora and Avicennia, thus influencing the reduction of magnitudes of carbon source/sink functions in the ecosystem during this season, even on high tide days.
Momentary versus Retrospective Sexual Consent Perceptions
Authors: Willis Malachi , Jozkowski Kristen N. 
Published: December 2021

AbstractPerceiving potential indicators of a person’s willingness is an integral component of sexual consent. Preliminary qualitative evidence using vignettes suggested that consent perceptions can change over the course of a sexual scenario. In the present study, we extended previous research by directly comparing momentary and retrospective sexual consent perceptions using a quantitative study design. Employing a staggered vignette protocol, we examined participants’ (n = 962; 72.0% female) momentary perceptions of fictional characters’ sexual consent and compared them with participants’ retrospective perceptions of the characters’ consent. We hypothesized that participants would demonstrate a hindsight bias in that they would retrospectively indicate they thought the fictional characters were first willing to engage in sexual behavior earlier than when they did momentarily. We found that differences in participants’ momentary versus retrospective perceptions of characters’ sexual consent varied by the type of behavior. As we expected, participants demonstrated a hindsight bias for making out. Contrary to our hypothesis, participants were hesitant to retrospectively report that the characters were willing to engage in the other sexual behaviors (e.g., oral, vaginal, anal sex) at a point earlier than their momentary perceptions. That momentary and retrospective sexual consent perceptions significantly differ corroborates previous recommendations that sexual consent be conceptualized as an ongoing process.
National nuclear forensics libraries: a case study on benefits and possibilities for identification of sealed radioactive sources
Authors: Vesterlund Anna , Canaday Jody , Chamberlain David B. , Curry Michael R. , Sandström Björn , Schnaars David D. , Ramebäck Henrik 
Published: December 2021

AbstractA National Nuclear Forensic Library (NNFL) is a useful nuclear forensics tool which consists of information and subject matter expertise on radioactive and nuclear (RN) materials produced, used or stored within a State. If RN material is found out of regulatory control the NNFL can be used as part of a nuclear forensics investigation to help identify whether or not the material is consistent with a country’s national holdings. In previous work, a number of signatures which can be useful to identify sealed sources of 241Am were investigated. To validate the measurement results, an official query concerning information about two of the previously investigated 241Am sources was sent to the United States Department of State, the international point-of-contact (POC) for the U.S. NNFL. The aim of this work is to show how data obtained in a characterization of a radioactive source can be used in conjunction with an NNFL to investigate the history of a source out of regulatory control.
Investigation of Fluorine-18 Labelled Peptides for Binding to Cholecystokinin-2 Receptors with High Affinity
Authors: Khan Naeem-Ul-Haq , Corlett Alicia , Hutton Craig A. , Haskali Mohammad B. 
Published: December 2021

AbstractMany cancers of neuroendocrine origin overexpress cholecystokinin-2 receptors (CCK-2R) including medullary thyroid cancer, small cell lung cancer and other lung carcinoids. Fluorine-18 labelled peptides targeting CCK-2R enable direct visualization and quantification of this receptor in vivo using positron emission tomography imaging. CP04 1 and MG11 2 are two previously described truncated peptides derived from the native CCK-2R hormone ligand, gastrin. The N-terminus of the MG11 2 octopeptide was chemically modified with various fluorine containing aromatic (4-fluorobenzoate), heterocyclic (6-fluoronicotinate) and aliphatic (2-fluoropropionate) moieties. To assess the impact these modifications had on CCK-2R binding, ligand-binding assays were conducted using A431 cells overexpressing human CCK-2R. MG11 2 modified by 4-fluorobenzoate (FB-MG11 3) demonstrated the highest binding affinity (0.20 nM) followed by MG11 2 modified by 6-fluoronicotinate (FNic-MG11 4; 0.74 nM) and 2-fluoropropionate (FP-MG11 5; 1.80 nM), respectively. Whilst indirect labelling of MG11 2 using fluorine-18 labelled activated esters of fluorobenzoate and 6-fluoronicotinate was unsuccessful, direct fluorine-18 labelling at the N-terminus modified with 6-nitronicotinate afforded a 47.6% radiochemical yield of [18F]FNic-MG11. Unfortunately, [18F]FNic-MG11 4 was chemically unstable, decomposing slowly through defluorination, thereby impeding any further work with this radiotracer.
Problem Gambling and Problem Gaming in Elite Athletes: a Literature Review
Authors: Håkansson Anders , Durand-Bush N. , Kenttä G. 
Published: December 2021

Abstract
Researchers have raised concerns about mental health in elite athletes, including problem gambling, where research hitherto is scarce. While gambling has been assessed in the younger student-athlete population, neither gambling nor the recently recognized behavioral addiction of gaming disorder has been sufficiently addressed in the elite athlete population. The present systematic literature review aimed to summarize research knowledge on the prevalence and correlates of problem gambling and problem gaming in elite athletes. Research papers were searched systematically using the Scopus, PsycINFO, and PubMed/MEDLINE databases and evaluated following a PRISMA paradigm. For the elite athlete population, eight reports on problem gambling and one report on problem gaming were found. While at least five papers indicated an increased risk of problem gambling in elite athletes compared to the general population, one study from Australia indicated the opposite. Problem gambling was generally more common in male athletes. Knowledge of problem gaming prevalence is thus far limited. It is concluded that increased research in problem gambling and problem gaming in elite athletes is warranted.
Neutrophils associate with Bowman’s capsule rupture specifically in PR3-ANCA glomerulonephritis
Authors: Hakroush Samy , Tampe Björn 
Published: December 2021

Abstract
Background
Renal involvement is a common and severe complication of ANCA (antineutrophil cytoplasmic antibody) associated vasculitis (AAV) potentially resulting in a pauci-immune necrotizing and crescentic antineutrophil cytoplasmic antibody (ANCA) glomerulonephritis (GN) with acute kidney injury (AKI), end-stage renal disease (ESRD) or death. We recently described that Bowman’s capsule rupture links glomerular damage to tubulointerstitial inflammation in ANCA-associated glomerulonephritis. Herein we provide a comprehensive histological subtyping of immune cell infiltrates in association with Bowman’s capsule rupture in ANCA GN.

Methods
A total of 44 kidney biopsies with ANCA GN were retrospectively included in a single-center observational study. Within a renal biopsy specimen, each glomerulus was scored separately for the presence of extensive and focal Bowman’s capsule rupture in injured glomeruli. Infiltrates of neutrophils, eosinophils, plasma cells, and mononucleated cells (macrophages, lymphocytes) were quantified as a fraction of the area of total cortical inflammation.

Results
Extensive Bowman’s capsule rupture was associated with tubulointerstitial inflammation containing infiltrates of neutrophils, eosinophils and plasma cells. A similar association was observed for the presence of focal Bowman’s capsule rupture, correlating with tubulointerstitial inflammation containing neutrophils, eosinophils and plasma cells. Multiple logistic regression confirmed that extensive Bowman’s capsule rupture correlated with tubulointerstitial inflammation containing neutrophils, and focal Bowman’s capsule rupture correlated with neutrophil and plasma cell infiltration. Furthermore, this association was specifically observed in PR3-ANCA GN.

Conclusion
To our knowledge, this is the first report linking Bowman’s capsule rupture directly to tubulointerstitial inflammation by immune cell subtypes. This underscores a pathomechanistic link between tubulointerstitial and glomerular lesions in ANCA GN and needs further investigation.

Graphical abstract
Oxidative stress and hepcidin expression in pediatric sickle cell anemia with iron overload
Authors: Elbostany Eman A. , Elghoroury Eman A. , Thabet Eman H. , Rashad Alaa A. , Rasheed Enas A. , El-Saeed Gamila S.M. , Abdelhalim Dalia A. , Abdelfattah Safa N. , Salama Iman I. , Salama Niveen 
Published: December 2021

Background:
Blood transfusion (BT) is essential in treating sickle cell disease (SCD); however, it leads to iron overload (IO) and oxidative stress. We studied the relationship between oxidative stress, iron status parameters, hepcidin mRNA gene expression, and IO in SCD patients.

Methods:
We classified all SCD patients (n = 90) into two groups: Group I, 45 children (s.ferritin ≥ 938 ng/mL) and Group II, 45 children (s.ferritin < 938 ng/mL). A total of 55 children, age and sex matched, participated as a control group. Malondialdehyde (MDA), nitrite, s.iron, s.total iron-binding capacity (sTIBC), transferrin saturation %, s.ferritin, s.hepcidin, and hepcidin mRNA gene expression were assessed.

Results:
Among SCD BT-dependent patients (>3 times/year), 63% were from Group I and 37% from Group II, p < .01. The two patient groups had significantly lower s.hepcidin and hepcidin gene expression than controls (p < .001). TIBC, s.iron, s.ferritin, transferrin saturation %, ferritin/hepcidin ratio, and MDA levels were higher among SCD patients than controls (p < .001). Group I had higher mean level of ferritin/hepcidin ratio and MDA than Group II (p < .01). The higher level of MDA and increased frequency of BT were the significant predicting risk factors for IO (p < .05). A receiver-operating characteristic curve indicates that MDA is the outstanding significant biomarker for high level of s.ferritin with subsequent IO progression.

Conclusion:
MDA may serve as a biomarker of oxidative stress and IO in SCD patients. This result paid attention for urgent initiation of antioxidant and chelation therapy on detecting increased MDA level.
Revision ofCerinomyces(Dacrymycetes,Basidiomycota) with notes on morphologically and historically related taxa
Authors: Savchenko A. , Zamora J.C. , Shirouzu T. , Spirin V. , Malysheva V. , Kõljalg U. , Miettinen O. 
Published: December 2021

Cerinomyces (Dacrymycetes,Basidiomycota) is a genus traditionally defined by corticioid basidiocarps, in contrast to the rest of the class, which is characterized by gelatinous ones. In the traditional circumscription the genus is polyphyletic, and the monotypic familyCerinomycetaceaeis paraphyletic. Aiming for a more concise delimitation, we reviseCerinomyces s.l.with a novel phylogeny based on sequences of nrDNA (SSU, ITS, LSU) and protein-coding genes (RPB1, RPB2, TEF1-α).We establish that monophyleticCerinomyces s.s.is best characterized not by the corticioid morphology, but by a combination of traits: hyphal clamps, predominantly aseptate thin-walled basidiospores, and low content of carotenoid pigments. In our updated definition,Cerinomyces s.s.encompasses five well-supported phylogenetic clades divided into two morphological groups: (i-iii) taxa with arid corticioid basidiocarps, including the generic typeC. pallidus; and (iv-v) newly introduced members with gelatinous basidiocarps, likeDacrymyces enatusandD. tortus. The remaining corticioid species ofCerinomyces s.l.are morphologically distinct and belong to theDacrymycetaceae: our analysis places the carotenoid-richCerinomyces canadensisclose toFemsjonia, and we transfer the clamps-lackingC. grandinioidesgroup toDacrymyces.In addition, we address genera related toCerinomyces s.l.historically and morphologically, such asCeracea,DacryonaemaandUnilacryma. Overall, we describe twenty-four new species and propose nine new combinations in bothCerinomycetaceaeandDacrymycetaceae.
The public health approach to suicide prevention in Ireland
Authors: Rochford S. , Dodd P. , Austin C. 
Published: December 2021

AbstractThis article provides an overview of the public health approach to suicide in Ireland. The authors provide detail on the current suicide prevention strategy in Ireland, Connecting for Life, which is a whole-of-government, systemic, multicomponent national strategy. As the strategy enters its final extended phase of implementation over the period 2020–2024, the public health elements of Connecting for Life are presented, including the population level and more targeted approaches. The findings of an interim review of the strategy are discussed, in addition to the local and national implementation structures which are in place to assist implementation and monitoring of the strategy.
Through COVID-19 and beyond: developing a multidisciplinary telehealth family intervention in first episode psychosis
Authors: O’Keeffe Donal , Marshall David , Wheeler Andrew , Allen Eoghan , Ronan Helena , Buckley Amy , Counihan Eimear , Clarke Mary 
Published: December 2021

AbstractThe COVID-19 pandemic presents unique challenges to high quality, safe Early Intervention in Psychosis (EIP) service provision. Due to the necessity to ensure EIP continues despite this, we developed a multidisciplinary, blended, telehealth intervention, incorporating psychoeducation and peer support, for family members of first episode psychosis service users: PERCEPTION. This perspective article aims to: describe PERCEPTION; offer reflections on our experience of delivering it; make recommendations for future research; and synthesise key learning to assist the integration of similar interventions in other EIP services. We provide a descriptive account of PERCEPTION’s development and implementation, with reflections from the clinicians involved, on supporting families using this approach. We experienced telehealth as patient-focused, safe, and efficient and believe the intervention’s blended nature augmented families’ engagement. The approach adopted can assist service providers to attain balance between protecting public health and offering a meaningful, therapeutic intervention to support families in the current epoch.
Jewish Ethics Regarding Refugees: Ideology and Realization
Authors: Rashi Tsuriel 
Published: December 2021

AbstractThis article addresses the Jewish ethical approach to refugees. According to Jewish ethics, help must be offered to refugees of a foreign people, and sometimes, for the sake of peace, even to those of an enemy state. Reviewing the Jewish sources, I conclude that from an ethical point of view, preference should be given to refugees who are near the border over those from farther away. Priority must be given to those in acute distress who lack the basic items of sustenance. Sometimes there is a special value in finding a way to assist even one's enemies in the hope that such help will break down the barriers of hatred. Similarly, it is ethically preferable to offer help to blameless children over adults, whose intentions might be suspect.
COSMOGENIC14CO FOR ASSESSING THE OH-BASED SELF-CLEANING CAPACITY OF THE TROPOSPHERE
Authors: Brenninkmeijer Carl A M , Gromov Sergey S , Jöckel Patrick 
Published: December 2021

ABSTRACTAn application of radiocarbon (14C) in atmospheric chemistry is reviewed.14C produced by cosmic neutrons immediately forms14CO, which reacts with hydroxyl radicals (OH) to14CO2. By this the distribution and seasonality (the lifetime of14CO is ∼1 month) of the pivotal atmospheric oxidant OH can be established.14CO measurement is a complex but unique application which benefitted enormously from the realization of AMS, bearing in mind that14CO abundance is of the order of merely 10 molecules per cm3not only provides14CO an independent measure for the OH based self-cleansing capacity of the troposphere, but also enabled detection of14C production due to high energy solar protons in 1989. Although its production takes place throughout the atmosphere and does not have the character of a point source, transport processes in the atmosphere affect the distribution of14CO. Vertical mixing in the troposphere renders gradients in its production rate less critical, but considerable meridional gradients exist. One question has remained open, namely confirmation of calculated14C production by direct measurement. A new sampling method is proposed. The conclusions are a guide to future work on14CO in relation to OH and atmospheric transport.
Decolonizing Authority: The Conflict on Wet'suwet’en Territory
Authors: Eisenberg Avigail 
Published: December 2021

AbstractOne of the leading features of colonialism is the imposition on a given territory and people a framework for what constitutes authority that renders pre-existing governing practices and legal orders unrecognizable as features of legitimate law and governance. Understood in this way, colonialism renders Indigenous law and governing practices invisible. As a result, decolonization requires changing how authority is apprehended and not only how it is distributed. This article compares two frameworks of authority in relation to the conflict on Wet'suwet’en territory: liberal postcolonial statism and relational pluralism. It shows how each framework provides a distinct lens through which to understand the pertinent features of political authority but argues that relational pluralism presents a better account of how to reconceive political authority in the context of real-world conflict.
Is consanguineous marriage related to spousal violence in India? Evidence from the National Family Health Survey, 2015–16
Authors: Rahaman Margubur , Sen Shalini , Rana Md Juel , Ghosh Saswata 
Published: December 2021

AbstractViolence against women is a global phenomenon, and intimate partner violence is the most common form of violence faced by women in the world. Around 30% of women in the world, on average, and 33% in India experience intimate partner violence during their lifetime. The main aim of this study was to investigate whether consanguinity protects women from spousal violence. National Family Health Survey 2015–16 (NFHS-4) data were used. The study sample comprised 60,824 currently married women aged 15–49 years. The results of the logistic regression model showed that the likelihood of all types of spousal violence against women was higher among consanguineous unions compared with non-consanguineous unions in India. The association between consanguineous marriage and spousal violence was found to be positive and significant in the southern and eastern regions of India and among Scheduled Castes and Scheduled Tribes. The association was not significant among Muslims. Differences in socio-cultural norms and practices across the regions of India, and among different socio-cultural groups, can perhaps explain these variations. Women belonging in higher age groups, from Other Backward Castes, those who were working and those with a low level of educational attainment and socioeconomic standing had a higher risk of experiencing intimate partner violence. Couples in a consanguineous marriage should be given adequate counselling to reduce intimate partner violence in India, and similarly culturally diverse countries. This would also help reach Target 5.2 of the Sustainable Development Goals by 2030.
Populist parties shifting the political discourse? A case study of the Economic Freedom Fighters in South Africa
Authors: Fölscher Marine , de Jager Nicola , Nyenhuis Robert 
Published: December 2021

ABSTRACTThis article examines the use of populist discourse in South African politics. We investigate speeches of leaders from the ruling African National Congress (ANC) and opposition parties, the Democratic Alliance (DA) and the Economic Freedom Fighters (EFF). We find that the EFF consistently employs populist appeals, while both the incumbent ANC and official opposition DA largely refrain. Our longitudinal analysis allows an examination of fluctuation across party leaders and electoral cycles, and illustrates that neither the ANC nor the DA have modified their political discourses in light of a rising populist challenger. However, there is some evidence that the two most dominant parties have reformed their programmatic offerings and behaviour in an attempt to compete with the EFF's popular appeal. The South African case offers important insights into the study of oppositional populism on the African continent, and a window into how major political parties may respond to emerging populist contenders.