bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness of Ipilimumab Plus Anti-PD-1 Therapy Versus Ipilimumab Alone in Patients With Metastatic Melanoma Resistant to Anti-PD-(L)1 Monotherapy
Authors: Peng Ye , Zeng Xiaohui , Peng Liubao , Liu Qiao , Yi Lidan , Luo Xia , Li Sini , Wang Liting , Qin Shuxia , Wan Xiaomin , Tan Chongqing 
Published: November 2021

ObjectiveThe use of ipilimumab plus anti-PD-1 has recently been shown to significantly improve the survival of patients with metastatic melanoma resistant to anti-PD-(L)1 monotherapy. The study assessed the cost-effectiveness of ipilimumab plus anti-PD-1 therapy in this population from the US payer perspective.Materials and MethodsA Markov model was created based on a retrospective analysis of patients with metastatic melanoma who were resistant to anti-PD-(L)1. Cost information was obtained from the Centers for Medicare and Medicaid Services and literature-based costs. The utility value was derived from the published literature. The results of the model was the total cost, quality-adjusted life-year (QALY), and incremental cost-effectiveness ratio (ICER). The uncertainty of the model was addressed through sensitivity analysis. In addition, we also conducted subgroup analysis.ResultsIpilimumab plus anti-PD-1 provided an improvement of 1.39 QALYs and 2.48 LYs, at a ICER of $73,163 per QALY. The HR of OS was the variable that had the greatest impact on ICER. Compared to ipilimumab, the probability of ipilimumab plus anti-PD-1 being cost-effective was 94% at the WTP of $150,000/QALY. The results of the subgroup analysis showed that the ICER in the majority of the subgroups was less than $150,000/QALY.ConclusionsIpilimumab plus anti-PD-1 was likely to be cost-effective compared to ipilimumab for patients with metastatic melanoma who are resistant to anti-PD-(L)1 at a WTP threshold of 150,000/QALY.
AMPD1 Is Associated With the Immune Response and Serves as a Prognostic Marker in HER2-Positive Breast Cancer
Authors: Wang Long , Zhang Xue , Wang Mengxue , Li Yunhai , Xu Jiali , Wei Jiaying , Li Hongzhong , Ren Guosheng , Yin Xuedong 
Published: November 2021

BackgroundAlthough immunotherapy has been used in the treatment of metastatic triple negative breast cancer (TNBC), its therapeutic influence on human epidermal growth factor receptor 2 (HER2)-positive subtype remains controversial. It is therefore imperative to find biomarkers that can predict the immune response in HER2+ BC.MethodsESTIMATE was utilized to compute the ImmuneScore and StromalScore from data obtained from TCGA database, and differentially expressed genes (DEGs) were identified. In addition, univariate Cox regression was used to assess candidate genes such as AMPD1, CD33, and CCR5. Gene set enrichment analysis (GSEA) was used to further understand AMPD1-associated pathways. Moreover, immunohistochemical analyses were performed to further reveal the relationship among AMPD1, CD4 and CD8 genes.ResultsThe expression of AMPD1 was markedly associated with disease outcome and tumor-infiltrating immune cells (TICs). In addition, AMPD1 was associated with lymph node status, age and the expression of PD-L1 and PD-L2. High AMPD1 expression was linked to longer overall survival (OS). Upregulated expression of AMPD1 correlated with the enrichment of immune-related signaling pathways. In addition, immunohistochemical analyses demonstrated a co-expression profile among AMPD1, CD4 and CD8 genes.ConclusionsTaken together, our data demonstrated that AMPD1 might serve as a novel biomarker for predicting the immune response and disease outcome in HER2+ BC.
Lack of Association between Chlamydophila psittaci and Ocular Adnexal MALT Lymphoma in Korean Patients—Is the Geographic or Genetic Difference Significant?
Authors: Cho Uiju , Cho Inju , Lee Sung Hak , Yang Suk Woo , Cho Seok Goo , Lee Youn Soo , Lee Hye Won , Park Gyeongsin 
Published: November 2021

Clamydophila psittaci (C. psittaci) has been proposed to be an etiologic factor in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the ocular adnexa. However, the pathogenetical significance of the infection has not been fully elucidated. Many previous studies have shown controversial results regarding C. psittaci detection rates in said patients, ranging from 0 to 87%. We investigated the presence of C. psittaci in a single institutional cohort (n = 150) of ocular adnexal MALT lymphoma (OAML) patients in Korea. We tried to exclude the methodological biases derived from the different primer sets in polymerase chain reaction-based studies. For that reason, we applied five sets of primers, including four previously reported and one newly designed primer set. There was no case of C. psittaci-positive OAML in repeated trials validated with appropriate positive and negative controls. All 150 cases showed negative results with five primer sets. These results suggest that the pathogenetic role of C. psittaci in ocular adnexal MALT lymphoma might have been overestimated to date, at least in the Korean population. Therefore, the molecular diagnosis of C. psittaci is considered a very low priority.
KEDUDUKAN PERJANJIAN BERSAMA (PB) TERHADAP PERJANJIAN KERJA BERSAMA (PKB) DALAM HUBUNGAN INDUSTRIAL
Authors: Singadimedja Muhammad Holy One N 
Published: November 2021

ABSTRAKLegally that the relationship between workers and employers are the same even though the socio-economic position between employees and employers is different, the nature of the employment law has resulted in employment relationships are not always harmonious between workers / unions and employers in industrial relations, the number of employers who eliminate or reduce workers' rights to conduct collective bargaining (PB) to deviate the collective Labour agreement (CLA), whereas in the company there has been a Labour agreement (CLA) is still valid by reason of the collective labor agreement (CLA), which is not in accordance with laws and regulations.The conclusion obtained is that the position of the Collective Agreement (PB) as a Source of Law Autonomous Employment Law is part of the Collective Labor Agreement for the duration of the validity of PKB there are things that do not fit in the employment relationship so it is possible made the Collective Agreement which will then be included in the change PKB with the provisions PB must be registered at the Industrial Relations court, the legal effect of the NT tertentangan with CLA, PB may be declared null and void, cancellation of PB can be done through the judicial land in the area of collective agreements made, since the Industrial Relations court has no competence to resolve disputes cancellation of the Collective Agreement. Keywords: Position, the Collective Agreement, Working Agreement
PERSAMAAN HUKUM KEBEBASAN BERPOLITIK ANGGOTA TENTARA NASIONAL INDONESIA DAN KEPOLISIAN NEGARA REPUBLIK INDONESIA DALAM PEMILIHAN UMUM DI INDONESIA
Authors: Kurniawan Basuki 
Published: November 2021

ABSTRACT The members of INA and PIR don’t give right to vote and be elected in general elections because there is worried about right to vote and be elected will be bringing on not neutral in general election, with the result that general elections principle is direct, general, secret, honest, and fair will not be achieved if right to vote and be elected is given. Although that worried still be able to debate in theoretical. It is becaused if right to vote and be elected for members of INA and PIR are given, so will not influence the vote result majority in general elections. The concept to give right to vote and be elected for members INA and PIR in general elections need to be implemented, because in the first general elections in 1955 the members of INA and PIR follow to vote and be elected in general election, and than there was not problem happen in thats time. Because of that be alternative thought bargained in this thesis; The concept of legal protection for members INA and PIR in political freedom is looked from human right protection principle is given freedom for members INA and PIR to vote the candidates house representatives, house representative region, house representative people, President and Vice President with free without any pressures from the institution INA and PIR. And than for the members INA and PIR propose their self as candidates the members House Representative, House Representative Region, House Representative People, President and Vice President permitted to be candidate as form of political freedom to every people Keyword: legal equality, political freedom, general election.
PERLAWANAN PIHAK KETIGA (DERDEN VERZET) TERHADAP EKSEKUSI BARANG BUKTI ATAS PUTUSAN PENGADILAN YANG TELAH BERKEKUATAN HUKUM TETAP( INKRACHT VAN GEWIJSDE) TERKAIT TINDAK PIDANA
Authors: Gunawan Fatria 
Published: November 2021

ABSTRACT A judge's decision concerning evidence in a criminal case is not closed, possibly causing problems in the future. Including the emergence of resistance by third parties who feel that their rights and interests have been harmed by the evidence.The research method used is a normative juridical research method with a conceptual approach, a legal approach and case approach.Based on the results of the study can be concluded first; Ratio Desidendy the decision of the Binjai District Court Number: 22 / Pdt.Plw / 2012 / PN.BJ dated 21 February 2013 that resistance was the guarantor of Darman's debt to the CV Showroom. Jaya Mobilindo because of the principal agreement to buy and sell 1 unit of car carried out by Darman with CV Showroom. Jaya Mobilindo, where resistance does not know the relationship between Darman and the Survived Als. Adi related to the a quo car unit. Therefore according to the provisions of article 24 of Law No. 42 of 1999 concerning the Fiduciary Guarantee above, then The opponent should not be burdened with the obligation to bear the risk of loss of objects that are used as fiduciary guarantees for unlawful acts committed by Suriadi Als. Adi, Defendant in Case No. 265 / Pid.B / 2012 / PN.BJ. Therefore, opponents are third parties with good intentions that must be protected by their rights and interests.Second: The third party's legal efforts to defend civil rights against the execution of evidence related to criminal offenses are by carrying out resistance efforts (derdenverzet. As an extraordinary legal measure used by third parties to refute or fight the execution of seizures carried out by the court. this law is carried out by third parties with the intention that their rights and interests are harmed as a result of the execution of seizure to get legal protection.Criminal legal measures can also be taken by third parties when their interests and rights are harmed as a result of a court decision in a criminal case. Third party property is used as evidence in a criminal case, because it is used by the defendant in committing a crime, so that one of the dictums of the court decision in the criminal case is confiscating evidence for a country that is actually owned by a third party that is not involved am criminal case. Keywords, Derden Verzet, Decision, Execution, Evidence, Criminal Act
PENENGGELAMAN KAPAL TERKAIT TINDAK PIDANA ILLEGAL FISHING SEBELUM ADANYA PUTUSAN PENGADILAN YANG BERKEKUATAN HUKUM TETAP
Authors: Prasetya Banan 
Published: November 2021

ABSTRACTThis research will be reviewed by the legal facts of the act of sinking illegal fishing vessels conducted by law enforcement officers or fisheries investigators in the Indonesian Fisheries Waters. The sinking of ships was carried out given the increasingly widespread theft of fish by foreign ships. An interesting legal issue to explore is about the sinking of illegal fishing vessels in a review of Indonesia's legal perspective. The purpose of this study is to analyse the sinking of ships related to the crime of illegal fishing before a court decision has permanent legal force, whether it is following applicable law. The next objective is to analyse the legal consequences of the ship sinking in the practice of enforcing illegal fishing criminal acts before a court decision has permanent legal force. This research is legal research with normative legal research type so that the analysis method used is a qualitative study that is built based on legal arguments to answer the problematic issues of this research law. The results showed that the act of sinking illegal fishing vessels in Indonesian fisheries waters by law enforcement officers or Indonesian fisheries investigators, normatively dogmatically, was following the provisions of Indonesian national law, which had been informed in Article 69 Paragraph 4 of Law Number 45 the Year 2009 regarding Fisheries, has also been by the provisions of international law, as regulated in Article 73 of UNCLOS 1982. Furthermore, the legal consequences of the sinking of illegal fishing vessels before the existence of a court decision have permanent legal force, normatively, has juridical implications on three things, namely: First, after the sinking of illegal fishing vessels became the basis for law enforcement officers or fisheries investigators to conduct further investigations within the formal criminal law enforcement framework; Second, the sinking of the ship has a legal effect on the status of the ship that sunk into status as evidence of the proceeds of crime or criminal acts that can be confiscated; Third, the sinking of the illegal fishing vessel has legal implications on the offender who can be subject to the status of a suspect and can even be raised to the status of a defendant of an illegal fishing crime. The author recommends that the Indonesian government through the foreign ministry should make diplomatic efforts to the international community to urge the United Nations to make illegal fishing a transnational crime. The procedure of permanent sinking of illegal fishing vessels, should not only be limited to the regulations of the Director-General of Fisheries but by the Indonesian government in the form of special legislation. Kata Kunci: Penenggelaman Kapal, Illegal Fishing, dan Penegakan Hukum
POLITIK HUKUM PEMBENTUKAN UNDANG-UNDANG PERLINDUNGAN SAKSI DAN KORBAN, DILIHAT DARI PERLINDUNGAN WHISTLEBLOWER (SAKSI PELAPOR) DAN SAKSI AHLI DI INDONESIA
Authors: Irawan Aris 
Published: November 2021

Abstract The configuration of legal politics always influences the development (character) of legal products. democratic political configurations always give birth to responsive character laws, the Eradication and Prevention Policy on Corruption, Collusion and Nepotism, which states that there is a need for a law regulating witness protection. In the light of the Witness and Victim Protection Act, it turns out that the law on the protection of witnesses and victims in terms of legal politics has not yet been able to meet the needs of the community. There should have been a government policy in the form of a law to protect the reporting witnesses or also called the Whistleblower, as well as expert witnesses, meaning that the existing laws are not in accordance with community needs (not responsive to community development) Keywords: Politics of Law, Legal Protection, Reporting Witness, Expert Witness
Pengaruh Media Tebak Gambar Terhadap Keterampilan Berbahasa Pada Siswa Kelas SD Negeri 05 Mendo Barat
Authors: Linda Lestari  , Dian Nuzualia Armariena  , Rury Rizhardi  
Published: November 2021

Penelitian ini dilatarbelakangi oleh fakta bahwa keterampilan berbahasa, terutama pada keterampilan berbicara siswa kelas III SD Negeri 05 Mendo Barat belum maksimal, terutama pada proses pembelajaran berlangsung. Penelitian ini bertujuan untuk mengetahui ada atau tidaknya Pengaruh Media Tebak Gambar Terhadap. Keterampilan Berbicara Pada Siswa Kelas III SD Negeri 05 Mendo Barat. Metode dalam penelitian ini menggunakan pre experimental design dengan desain penelitian the one-group pretest-posttest design. Populasi dalam penelitian ini adalah seluruh siswa-siswi kelas III yang mengikuti pembelajaran di SD Negeri 05 Mendo Barat. Pengambilan sampel dalam penelitian ini yaitu menggunakan teknik total sampling sebanyak 30 siswa. Proses penelitian dilakukan sesuai dengan langkah- langkah yang telah ditetapkan melalui penilaian keterampilan berbicara berdasarkan rangsang gambar oleh Nurgiyantoro (2012). Dalam penelitian ini peneliti melakukan teknik analisis data yaitu menggunakan uji t. Berdasarkan analisis data yang telah dilakukan uji t menunjukkan nilai thitung = 9,742 lebih dari ttabel (0,05) (dk=n-1)=2,045 sehingga H0 ditolak. Sedangkan untuk nilai sig. Sebesar 0,000 < 0,025. Dapat disimpulkan bahwa Terdapat Pengaruh Media Tebak Gambar Terhadap Keterampilan Berbicara Pada Siswa Kelas III SD
Negeri 05 Mendo Barat.
Pemodelan Persentase Penduduk Miskin Kabupaten/Kota di Provinsi Jawa Barat dengan Pendekatan Regresi Nonparametrik Spline Truncated
Authors: Dani Andrea Tri Rian , Ni'matuzzahroh Ludia 
Published: November 2021

Estimator Spline Truncated adalah salah satu pendekatan dalam regresi nonparametrik yang dapat digunakan ketika pola hubungan antara variabel respon dan variabel prediktor tidak diketahui dengan pasti polanya. Estimator Spline Truncated memiliki fleksibilitas yang tinggi dalam proses pemodelan. Pada penelitian ini bertujuan untuk memodelkan persentase penduduk miskin Kabupaten/Kota di Provinsi Jawa Barat dengan menggunakan model regresi nonparametrik estimator Spline Truncated. Metode estimasi yang digunakan adalah Ordinary Least Squares (OLS). Kriteria kebaikan model regresi nonparametrik yang digunakan adalah Generalized Cross-Validation (GCV). Berdasarkan hasil analisis, diperoleh model terbaik dari regresi nonparametrik Spline Truncated, yaitu model dengan 3 titik knot, dimana diperoleh nilai GCV minimum sebesar 2.14. Berdasarkan hasil pengujian hipotesis, baik secara simultan maupun parsial, diketahui bahwa variabel prediktor yang digunakan pada penelitian ini, berpengaruh signifikan terhadap persentase penduduk miskin, dengan nilai koefisien determinasi sebesar 95.33%.
LEXICAL AND STYLISTIC FEATURES OF TRANSLATION OF DIPLOMATIC TEXTS (BASED ON THE TEXTS OF THE MINISTRY OF FOREIGN AFFAIRS OF RUSSIA WEBSITE INTHEPERIODOF 2018-2019)
Authors: Засецкова Елена Николаевна , Курникова Наталия Сергеевна 
Published: November 2021

В настоящей статье исследуются лексико-стилистические особенности дипломатических текстов путем сравнения текстов оригинала и перевода с применением сопоставительного анализа для выявления наиболее успешной стратегии перевода.Статья представляет выводы по результатам анализа 590 единиц, взятых из выступлений, пресс-конференций и интервью Министра иностранных дел Российской Федерации С. В. Лаврова и его представителей, а также брифингов и комментариев официального представителя МИДа России М. В. Захаровой. Предметом настоящего исследования выступают лексико-стилистические особенности перевода дипломатического текста. Целью исследования является выявление и анализ лексико-стилистических особенностей дипломатического текста в аспекте перевода. Для достижения поставленной цели исследования авторами были использованы следующие методы: сравнительно-сопоставительный и аналитический. В результате исследования было установлено, что при передаче лексических особенностей дипломатического текста переводчики наиболее часто используют такие приемы, как калькирование и смысловое развитие. При переводе стилистических особенностей используются такие приемы, как калькирование, эквивалентный перевод, деметафоризация и функциональная замена.
This article examines the lexical and stylistic features of diplomatic texts by comparing the original and translated texts with the use of comparative analysis to identify the most successful translation strategies. The article presents the results of the analysis of 590 items from the speeches, press conferences and interviews of the Minister of Foreign Affairs of the Russian Federation Sergey Lavrov and his representatives, as well as the briefings and comments of the official representative of the Russian Foreign Ministry Maria Zakharova. The subject of this study is the lexical and stylistic features of the translation of diplomatic texts. The goal of the study is to identify and analyze the lexical and stylistic features of the diplomatic text in the aspect of translation. To achieve the goal of the study, the authors used the following methods: comparative and analytical methods. As a result of the study, it was found that when translating the lexical features of the diplomatic text, translators most often use such techniques as calquing and semantic development. When translating stylistic features, translators use such techniques as calquing, equivalent translation, demetaphorization, and functional substitution.
NATIONAL IDENTITY AND FEATURES OF ITS REFLECTION IN THE MODERN DRAMA OF THE VOLGA REGION
Authors: Кириллова Ирина Юрьевна 
Published: November 2021

Статья посвящена вопросу национальной специфики литератур народов Поволжья, соотношению национального и регионального в понимании идентичности как таковой. В работе выявляются общие моменты в отражении национальной идентичности, этнических и общечеловеческих ценностей в современной драматургии Поволжья. В качестве объекта исследования выбраны произведения современных чувашских и татарских драматургов, в которых наиболее ярко выражена национальная проблема. Путем сравнительного анализа в статье рассмотрены формы проявления национальной идентичности в произведениях, такие как национальные мифы, образы, идеалы, архетипы, обращение к далекому прошлому народа, к типичным чертам национального характера. Важным идеологическим ресурсом национальной идентичности на современном этапе выступило историческое прошлое чувашского и татарского народов. В судьбе главных исторических личностей отразилась трагическая судьба булгарского народа. В чувашской драме «Часы с кукушкой» (2016) М. Карягиной и татарской монодраме «Микулай» (2019) М. Гилязова проблема идентичности рассматривается в отношении героев к национальным и общечеловеческим ценностям, таким как родная земля, дом, семья, память, нравственность, долг, ответственность и др.
The article is devoted to national specifics of the literatures of the peoples of the Volga region, the correlation of national and regional to the understanding of identity as such. The paper reveals common points in the reflection of national identity, ethnic and universal values in the drama of the Volga region. The works of modern Chuvash and Tatar playwrights, in which the national problem is most clearly expressed, are chosen as the object of research. By means of comparative analysis, the article considers the forms of national identity in the works, such as national myths, images, ideals, archetypes, reference to the distant past of the people, to the typical features of the national character. An important ideological resource of national identity was the historical past of the Chuvash and Tatar peoples. The fate of the main historical figures reflected the tragic fate of the Bulgarian people. In the Chuvash drama “The Cuckoo Clock” (2016) by M. Karyagina and the Tatar monodrama “Mikulai” (2019) by M. Gilyazov, the problem of identity is considered in the relation of their characters to national and universal values, such as their native land, home, family, memory, morality, duty, responsibility, etc.