bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of Curcuma longa on fasting blood glucose, MMP-9 and IFN-γ in diabetes mellitus: an experimental study
Authors: Ovaditya Shafira Zahra , Brilliantika Surya Pratama , Chodidjah Chodidjah , Sumarawati Titiek 
Published: January 2025

Background: Turmeric (Curcuma longa) contains curcumin as an active ingredient that has ability as a potent antioxidant and antiinflammation. Turmeric extract can improve glucose level and surpress micro and microangiopathy complication in Diabetes Mellitus Type 2. The aim of this study was to investigate the role of turmeric extract administration on fasting glucose level, MMP-9, and IFN-γ.
Methods: Experimental PostTest Only Control Group Design study was conducted. Twenty four Wistar rats aged 2 months weighing 180-200 grams were adapted for 2 days, divided into 4 groups randomly: negative control group induced by STZ-NA only (P1), positive control group induced by STZ-NA and received metformin 45mg/kgBW/day (P2), treatment group induced by STZ-NA and received turmeric extract 200mg/kgBW/day (K1), and ), treatment group induced by STZ-NA and received combination of metformin 22,5mg/kgBW/day and turmeric extract 100mg/kgBW/day. The levels of fasting glucose serum were measured by spectrophotometric method, while ELISA measured the levels of MMP-9 and IFN-γ.
Results: Mean + SD Fasting blood glucose level was decreased respectively from K1, K2, P1 and P2 (277.00 + 4.00, 100.00 + 2.00, 98.04 + 3.00, 92.00 + 3.00 mg/dl). MMP-9 level was decreased respectively from K1, K2, P1 and P2 (653.09 + 18.00, 328.00 + 14.00, 156.00 + 4.00, 131.00 + 4.00 ng/ml). IFN–γ level was decreased respectively from K1, K2, P1 and P2 (300 + 16.00, 85.00 + 3.00, 61.05 + 2.04, 49.00 + 1.09 ng/ml.) Kruskal Wallis test for Fasting blood glucose, MMP-9, dan IFN–γ shows significant differences among groups. (p=0.004, p=0.004, dan p=0.004). Using post hoc test, all groups significantly differ with p=0.000.
Conclusion: The administration of turmeric extract improves fasting glucose level, MMP-9, and IFN-γ in type 2 DM Wistar rats
Correlation of 5-minutes heart rate variability with health performance of resident physicians in covid 19 pandemic
Authors: Ridwan Muhammad , Pamungkas Subhan Rio , Husna Fauzul , Syafrida Willa Mutia , Lestari Inda 
Published: January 2025

Introduction: Resident physicians have high exposure risk and infection rate of Covid 19. Their health condition is one of determining factors in Covid-19 prevalence. Thus, we evaluated the following variables: exercise capacity, Resting Heart Rate (RHR), several body compositions from Bioelectrical Impedance Analysis (BIA), and Body Mass Index (BMI) that resemble health conditions. Then, those variables were correlated with HRV (Heart Rate Variability), which strongly influences fitness and immunity.
Method: This cross-sectional study was conducted from March to September 2021 and involved 149 resident physicians in medical faculty of Universitas Syiah Kuala. The basic data of respondents was filled in through questionnaires and other data obtained from measuring HRV, RHR, 6 minutes walk test (6mwt), BIA, and BMI. We used Spearman's correlation to assess the relationship of each data with HRV.
Result: Standard deviation of NN interval (SDNN) and low frequency (LF) negatively correlated with RHR (p = 0.000, r = -0.400 and p = 0.000, r = -0.332, respectively); BMI (p = 0.004, r = -0.233 and p=0.024, r=-0.185); and BIA variable (total fat) (p = 0.000, r = -0.286 and p=0.000, r=-0.319). SDNN and LF positively correlated with 6MWT (p= 0.040, r= 0.169 and p=0.021, r=0.189).
Conclusion Increasing exercise capacity plays an important role in increasing fitness levels, which is marked by increased HRV values. While the increase in RHR, BIA, and BMI values ​​causes a decrease in HRV values ​​, indicating a decrease in fitness level.
Chronic limb-threatening ischemia Rutherford VI, successful infra inguinal stenting: a case report
Authors: Zulfa Putri Oktaviani , Habibie Yopie Afriandi 
Published: January 2025

Introduction: Chronic limb-threatening ischemia (CLTI) is a remarkably morbid condition that causes significant mortality, limb loss, pain, as well as reduce health-related quality of life in those who are affected. The cornerstone of CLTI therapy is revascularization, which can lower the amputation rate.
Case description: A diabetic type II 68-year-old female patient presented with complaints of pain, swelling, and itching in the left leg that was felt for approximately 1 month ago. The wound persists although the ankle was already amputated. CT-angiography showed total occlusion in 1/3 distal of left femoral artery and no visualization of left popliteal artery. She was diagnosed as left CLTI femoral popliteal Rutherford VI TASC II type D with ischemic rest pain. The patient planned for an endovascular revascularization procedure. Victory 14 wire 0.014” was inserted but recanalization did not penetrate, continued with Victory 18 wire the lesion could penetrate. Digital Subtract Angiography (DSA) evaluation found significant residual stenosis, thus continued using Abbott Supera peripheral stent system. The patient was successfully treated showed left femoral artery was seen well visualized with TIMI flow 3, left popliteal artery was still seen 50% no significant residual stenosis with TIMI flow 2. Followed up after 3 months, she did not complain any ischemic pain at left leg.
Discussion: The Supera peripheral stent system was developed to withstand the femoropopliteal artery's unique stressors. There have been few studies on the use of supera stenting in complex CLTI, and the primary patency at 1 year was 77% in lesions measuring 92-236 mm. In this case report, the procedure was successfully applied in complex CLTI (mean length >200mm) with no restenosis and repeat target limb revascularization after one year of procedure.
Conclusion: We successfully performed revascularization using supera stenting, and the femoropopliteal artery showed good TIMI flow results. In CLTI patients, stenting may be an option to lower the risk of major lower limb amputation.
Mechanism of neurological deficit improvement through analysis in cerebral artery stenosis, Endothelial Progenitor Cells (EPC), Asymmetric Dimethylarginine (ADMA), Malondialdehyde (MDA), and Superoxide Dismutase (SOD) after balloon angioplasty procedure in ischemic stroke patients
Authors: Musadir Nasrul , Soetojo  , Syahrul  , Sudiana Ketut , Utomo Budi , Muhammad Hamdan  , Usman Fritz Sumantri , Siti Pariani  
Published: January 2025

Link of Vodeo Abstract: https://youtu.be/tOBWYoEAbiw

Backgrounds: Balloon angioplasty is one of the endovascular procedures which aims to open atherosclerotic stenosis or occlusion of the cerebral blood vessels. Balloon angioplasty has been performed on ischemic stroke patients with arteriosclerotic stenosis. However, the procedure's outcomes vary, and no microcellular indicator has become a standard for balloon angioplasty.
Methods: NIHSS examination and Digital Subtraction Angiography (DSA) were performed on 35 ischemic stroke patients. NIHSS examination is used to determine the severity of neurological deficits. At the same time, Digital Subtraction Angiography (DSA) is a diagnostic procedure to determine the location and size of the stenotic lesion in the arteries. Patients underwent several laboratory biomarker analyses, including EPC, ADMA, MDA and SOD, followed by balloon angioplasty. Afterward, repeat the DSA procedure. EPC, ADMA, MDA and SOD were re-analysed seven days later and NIHSS was re-examined thirty days after balloon angioplasty.
Results: Stenosis, EPC (p<0.001), MDA (p=0.001), SOD (p=0.001), and NIHSS (p<0.001) have significant output before and after balloon angioplasty (p<0.001). EPC and SOD significantly correlate with neurological deficits alteration (p<0.05). EPC and SOD have a cut-off value of 50% improvement in neurological deficits. EPC and SOD significantly improve neurological deficit (p=0.008 and p<0.001).
Conclusion: The mechanism of neurological deficit improvement in balloon angioplasty procedure happened through the elevation of EPC and SOD levels. The outcomes of balloon angioplasty could be estimated by measuring the EPC and SOD values as the standard for indicators adjustment to measure clinical progress after balloon angioplasty in ischemic stroke patients.
Bevacizumab and triamcinolone acetonide intravitreal effect on Transforming Growth Factor Beta (TGF-β) and Plasminogen Activator Inhibitor-1 (PAI-1) expression in open globe injury model
Authors: Abiyoga Kautsar , Delfitri Lutfi  , Yulia Primitasari  , Citra Dewi Maharani  , Clarisa Finanda  , Wimbo Sasono  , Nurwasis  , Evelyn Komaratih  , Joko Legowo  
Published: January 2025

Introduction: Triamcinolone acetonide (TA) and bevacizumab have anti-inflammation and anti-proliferation in the wound-healing process caused by ocular injury. There was no medicament to treat ocular injury besides corticosteroids and anti-VEGF, but their comparison is not yet elucidated. This study aimed to compare the effects of injection of intravitreal triamcinolone acetonide and bevacizumab in an expression of TGF-β and PAI-1 in an experimental rabbit model of open-globe injury (OGI). TGF beta and PAI-1 have an important role in the hemostasis of the wound healing process, wherein the eye, the wound healing process should not occur excessively because it can cause PVR (unlike wound healing in the skin or other organs in the body).
Methods: This study was an experimental study of 30 eye rabbits with an OGI model. Six eyes as control and 24 eyes received treatment for 21 days. Thirty Male New Zealand rabbits and we make OGI in the superotemporal quadrant of the right eyes by making a 5 mm circumferential incision, 6 mm behind the limbus. TA and bevacizumab were treated in different groups. The subjects were divided into several groups: A) OGI group (PC), (B) OGI with intravitreal TA group 3 days after (T3), (C) OGI with intravitreal TA group 7 days after (T7), (D) OGI with intravitreal bevacizumab group 3 days after (B3), and (E) OGI with intravitreal bevacizumab group 7 days after (B7). A negative control group (NC) was randomly selected, including five left eyes from the treatment group (n = 6 each). All eyes were examined and evaluated by measuring the expression level of TGF-β and PAI-1. Normality test was done using Shapiro-Wilk, and the expression was compared using One-way ANOVA and Tukey post-hoc test.
Results: The expression of PAI-1 was significantly lower in the treatment group than in the control group (PC) (PC = 10,08 ± 1,23 %, p-value 0,0444). However, the expression of TGF-β was higher in the treatment group compared to the control group (PC) (PC = 6,60 ± 3,30 %, p-value 0,0228).
Conclusion: Triamcinolone acetonide and bevacizumab treatments after OGI significantly weakened the upregulation of PAI-1 but could not reduce TGF-β expression in the retina and wound site tissue. It reduces the risk of developing posttraumatic complications of proliferative vitreoretinopathy (PVR).
Scleromalacia perforans in young patient: a unique case
Authors: Karima Annisa , Lutfi Delfitri , Awalia  , Zuhria Ismi 
Published: January 2025

Link of Video Abstract: https://youtu.be/gC8cCxUUSQc

Background: Scleromalacia perforans is a systemic autoimmune disease such as rheumatoid arthritis, lupus, and Wegener's granulomatosis that may compromise vision and globe integrity. The great challenge to treat disease is determined by the genetic examination. This case report aims to describe a unique case of Scleromalacia perforans in young patient.
Case description: A 19-year-old female with a progressed protrusion of the left eye since she was 1 year old. Six years ago, she had redness, worsen protrusion, photophobia, tearing, and pain, but resolved without treatment. Her cousin had the same condition but refused to continue the examination. Visual acuity of the left eye was no light perception with 4x4 mm of corneal leukoma, and 360 degrees of anterior scleral ectasia covered with conjunctival neovascularization. USG showed posterior vitreous detachment and 28,9 mm axial length. ANA test and HLA B27 were normal, positive hypermobility joint, and Rheumatologists ruled out the possibility of autoimmune disease. Myoconjuctival enucleation was performed with a dermis fatty graft for cosmetics, and histopathological examination showed nonspecific chronic inflammation.
Conclusion: Scleromalacia perforans is a rare case that is strongly believed to have an association with systemic autoimmune disease. Collaboration between ophthalmologists, rheumatologists, and geneticists is essential to manage this case.
Clinical improvement of gastroesophageal reflux disease (GERD) patients with warm ear stimulation, initial exploratory study on the anterior branch of the vagal nerve (Jacobson's nerve)
Authors: Saleh Arman Yurisaldi , Zakaria Hasballah , Allya Paramita Koesoema  , Retno Yulianti  , Prabowo Imam , Taufiq Fredrik Pasiak  
Published: January 2025

Link of Video Abstract: https://youtu.be/mVByi-Qg-xo

Introduction: Jacobson's nerve, also known as the auricular branch of the vagus nerve, is situated on the medial part of the earlobe. Research has demonstrated that electrical stimulation of this nerve can influence various aspects of gastrointestinal motility and function. This study investigated how warm stimulation affects Jacobson's nerves as an adjuvant therapy in patients with gastroesophageal reflux disease (GERD).
Methods: The investigation was carried out using a single-blind design, wherein the participants were unaware of their assigned group and the nature of the ear-warming therapy they were getting, whether genuine or placebo. The present study involved a sample of 15 individuals who were diagnosed with gastroesophageal reflux and had undergone medical treatment. The participants were allocated into three distinct groups for the study. Group 1 was administered anti-gastritis medication and instructed to utilize ear warmers. Group 2 was given a placebo medication and required a device resembling an ear warmer. Lastly, Group 3 was solely administered anti-gastritis medication without additional ear warmers instructions.
Results: This study showed a significant difference between the three groups after the intervention (p = 0.03). Post-intervention comparison between groups 1 and 3 revealed a significant difference [9 (3-11) vs 15 (14-16), p = 0.008].
Conclusions: Warm stimulation can serve as a viable and secure supplementary therapeutic approach for individuals diagnosed with gastroesophageal reflux disease (GERD).
Immunohistochemical examination of recurrence and giant cell tumor specificity, is it correlated? cohort retrospective study
Authors: Surachman Achmad Jadi Didy , Kamal Achmad Fauzi , Septelia Inawati Wanandi , Siregar Nurjati Chairani , Rahyussalim  , Alida Roswita Harahap , Dewi Soemarko Sumaryani 
Published: January 2025

Link of Video Abstract: https://youtu.be/h3ku5ujtEY4

Introduction: GCT is a benign tumor that has an aggressive local character. GCT recurrence after disinfection still often occurs. The reasons for treatment failure and triggering a recurrence are believed to be the role of the accumulation of stem cells in promoting tumor initiation and recurrence.
Methods: Study Cohort Retrospective cohort in patients who had undergone surgery with a diagnosis of GCT at RSUPN Dr. Cipto Mangunkusumo in 2017-2022. The subjects were separated into two groups, recurrence patients and non-recurrence patients. The tissue biopsy will be assessed with ALCAM+, Oct4, and Stro-1 biomarkers for tumor stem cells.
Results: A total of 38 patients were diagnosed with Giant Cell Tumor. There were 31.6% of recurrent patients with an age range between 31-40 years and 41-50 years. The most common location is the Distal Radius with a score of 41.7% in recurrent patients and 38.5% in non-recurrent patients. Based on the data, the expression of ALCAM+, OCT4 and Stro-1 did not have significant differences between the two groups. The Recurrence group in p63 was expressed more than in the Non-Recurrence group p=0.002. In CD147, the Recurrence group was also expressed more than in the Non-Recurrence group p=0.003
Conclusion: Increased expression of ALCAM+, OCT4, and Stro-1 occurred in Recurrence and Non-Recurrence patients, although Stro-1 appeared to be more sensitive in detecting GCT progression, but was not statistically different. CD147 and p63 are statistically different between recurrence and non-recurrence.
Preliminary study: the future insight of relationship between nutrigenomic risk and sepsis
Authors: Veterini Anna Surgean , Semedi Bambang Pujo , Airlangga Prananda Surya , Rejeki Purwo Sri , Firdaus Khildan Miftahul , Mutiar Airi , Adi Annis Catur , Sumara Rauzan , Meirawan Rizky Fajar 
Published: January 2025

Link of Video Abstract: https://youtu.be/K5y8Rmm7JZk

Introduction: In field observations, we frequently encountered cases of sepsis at a young age and rarely in older individuals. Most cases are caused by a bacterial infection, which causes pneumonia that progresses to septic shock. There are several possible causes of infection and subsequent septic shock. Among these, certain genetic code abnormalities cause disturbances in nutrient metabolism, which facilitates the emergence of infections. This study aimed to explore the nutrigenomic patterns in patients with septic shock.
Methods: Nutrigenomic examination was performed at the General Academic Hospital in Surabaya, Indonesia, to determine the micronutrient genotype risk in patients with septic shock. We compared cases of septic shock with control groups containing normal subjects to identify a unique pattern in the nutrigenomic results between these two groups. DNA testing was in collaboration with Nutrigenme, using saliva and buccal swabs. The data were analyzed using the chi-square test and all statistical analyses were performed using the R statistics software.
Results: The results of the saliva testing demonstrated that there was an endurance ultra-risk category (PGC1a, rs8192678; genotype GG) in the control group; however, this category was not observed in the case group. In addition, the genomic risk of vitamin C was elevated in the septic shock group (Group A) but was typical in the control group (Group B).
Conclusion: We observed a deletion in GSTT1 rs2266633 in the sepsis group, which may play a role in the development of sepsis. Furthermore, we discovered that the control group exhibited an ultra-type risk for endurance, suggesting that the ability to extract oxygen and frequent exercise may play a role in limiting disease development.
The role of urine Angiotensin-II (ANG-II) in predicting the occurrence of Acute Kidney Injury (AKI) induced by sepsis in children
Authors: Abdullah Arwini Avissa , Ganda Idham Jaya , Lawang St. Aizah 
Published: January 2025

Link of Video Abstract: https://youtu.be/ml-58zJ21gM

Background: The incidence of AKI has increased by 2.8% per year. Sepsis is one of the main causes of AKI. Sepsis is a major cause of intensive care unit (ICU) mortality and morbidity in developing countries. ANG-II is an active peptide of the renin-angiotensin system (RAAS) that activates pro-inflammatory and pro-fibrotic pathways associated with the development of AKI. This study aims to identify the role of urinary angiotensin-II (ANG-II) in predicting the occurrence of acute renal impairment due to sepsis in children.
Methods: This study was an observational study with a prospective cohort approach. The population of this study were sepsis patients who initially did not experience AKI aged 1 month to 18 years who were hospitalized in the PICU with a total sample of 40 samples. Data were analyzed using SPSS version 25.0 for Windows.
Results: Based on the results of statistical tests using univariate tests, it was found that there was an association between ANG-II values and AKI in pediatric patients with sepsis, with higher values in children with AKI. Urinary Angiotensin-II value of 207.63 ng/ml is a predictor value of AKI in pediatric patients with sepsis with a sensitivity value of 76.7% and sensitivity of 70%.
Conclusion: This study concludes that urinary Angiotensin-II value can be used to predict the incidence of AKI in pediatric patients with sepsis.
Effectiveness of conditioned medium mesenchymal stem cells intracutaneous for trophic ulcer due to morbun hansen
Authors: Tan Sukmawati Tansil , Firmansyah Yohanes , Halim Kelvin Cristian , Aisyah Putri Bennya , Hendrawan Siufui 
Published: January 2025

Link of Video Abstract: https://youtu.be/S9VOt1uCYlY

Introduction: The facts in the field that more than 50% of chronic ulcers, especially trophic ulcers due to leprosy fail to heal with usual treatment. Stem cell therapy or one of them is conditioned medium mesenchymal stem cell is a promising therapy because of its biological and physiological processes resembling the mechanism of wound healing
Methods: This research is a clinical trial research "Open Trial" Phase 2 to see the side effects caused by the intervention. Minimum sample size of 20 respondents with trophic ulcers due to leprosy that is difficult to resolve with usual treatment. The main outcome is wound healing in terms of the length and extent of the wound. The secondary outcome is treatment toxicity 4 weeks after administration. Follow-up visits will be scheduled at 2, 4, and 12 weeks post-treatment.
Results: 24 of 27 respondents successfully followed the study until the end. Prior to intracutaneously injecting CM MSC, the mean width, length, and area of tropical ulcers in patients with Morbus Hansen were 1.1 (0.3 - 12.0) cm, 2.0 (0.5 - 9.0) cm, and 2.38 (0.25 - 108) cm square, and after intracutaneously injecting CM MSC at the first follow up were 1.0 (0 - 4.5) cm, 1.5 (0 - 8.5) cm, and 1.0 (0 - 38.25) cm. The change between the start and finish of the intervention was statistically significant (p-value 0.05). Neither systemic nor local adverse effects were observed during or up to two months after the intervention.
Conclusion: The use of intracutaneous CM MSC injection has been proven effective in accelerating the process of wound healing, especially trophic ulcers due to leprosy with side effects that are not present in this study.
Perioperative factors of fast track extubation success following coronary artery bypass graft surgery: a literature review
Authors: Wiratama Siddiq , Sembiring Yan Efrata , Setiawan Philia 
Published: January 2025

Introduction: Various studies have shown that fast-track cardiac care which its final aim is for early extubation after surgery, reduces hospital length of stays, cost, and post-operative morbidity rate. The main purpose of this study is to evaluate some perioperative factors as an independent predictor for a successful outcome for fast-track extubation (FTE) in patients undergoing coronary artery bypass graft surgery (CABG).
Method: This study analyzed multiple references using the keyword “Fast track Extubation”, “Perioperative Factors”, and “CABG”. Search engines such as PubMed, Google Scholar, ProQuest, and ClinicalKey were used to search for relevant papers from the last 15 years. We obtained total of 6 articles that meet our review criteria. We excluded some articles for not meeting our review methods considerations and by the year of publication that does not meet our standard.

Result: A total of 6 studies were identified regarding fast tract extubation post-CABG procedure. Numerous risk factor has been identified for successful of fast tract intubation after intubation such as post-operative bleeding, aortic cross-clamp time, cardio-pulmonary bypass time, chronic obstructive pulmonary disease, atrial fibrillation, ejection fraction pre-operative, diabetes mellitus, renal function, and patient age.
Conclusions: This study confirms that better perioperative profile such as age, good ejection fraction >40% has better chance for FTE success in patients undergoing CABG surgery.