bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the cell cycle progression score to differentiate indolent from aggressive prostate cancer in men diagnosed through transurethral resection of the prostate biopsy
Authors: Cuzick Jack M. , Stone Steven , Lenz Lauren , Flake Darl D. , Rajamani Saradha , Moller Henrik , Berney Daniel Maurice , Cohen Todd , Scardino Peter T. 
Published: August 2021

AbstractBackgroundValidation of biomarker‐based prognostic models to improve risk stratification in men with localized prostate cancer (PrCa) remains a clinical need. It has previously been shown that the cell cycle progression (CCP) test provides significant, independent prognostic information for men who were incidentally diagnosed with PrCa after transurethral resection of the prostate (TURP) and were conservatively managed.AimThe results have been extended in a newly analyzed retrospective cohort of UK men diagnosed through TURP biopsy (TURP1B; N = 305).Methods and ResultsThe CCP score was derived from TURP biopsy tissue and combined with a modified UCSF Cancer of the Prostate Risk Assessment score (CAPRA) to generate the clinical cell‐cycle risk score (CCR). The primary endpoint was PrCa‐specific mortality (PSM). Hazard ratios (HR) were calculated for a one‐unit change in score. Median follow‐up was 9.6 (IQR: 5.4, 14.1) years, and 67 (22%) men died from PrCa within 10 years of diagnosis. The median CCP score was 1.1 (IQR: 0.6, 1.7). In univariate analyses, CCR proved a significant prognosticator of PSM (HR per unit score change = 2.28; 95% CI: 1.89, 2.74; P = 1.0 × 10−19). In multivariate analyses, CCR remained a significant prognosticator of PSM after adjusting for CAPRA (HR per unit score change = 4.36; 95% CI: 2.65, 7.16; P = 1.3 × 10−8), indicating that its molecular component, CCP, provides significant, independent prognostic information.ConclusionThese findings validate a combined clinicopathologic and molecular prognostic model for conservatively managed men who are diagnosed through TURP, supporting the use of CCR to inform clinical management.
An Insight into Tunable Innate Piezoelectricity of Silk for Green Bioelectronics
Authors: Veronica Asmita , Hsing I‐ming 
Published: August 2021

AbstractCommercially available bioelectronics account for significant percentage of e‐waste, especially battery waste, that demand immediate intervention due to rising environmental concerns. Consumers are becoming increasingly aware and cautious of their contribution to carbon footprint on a regular basis. It has become imperative to adopt sustainability in every aspect of production of bioelectronics taking into consideration the growing market for wearable healthcare monitoring system. Green electronics is a relatively new concept gaining tremendous attention within the scientific and industrial community with the ultimate goal of employing organic, biodegradable, and self‐sustainable system to replace the conventional inorganic battery‐powered electronics. Silk is a green material that has been extensively explored for its use in functional electronics due to its tunable biodegradability and flexibility. Nevertheless, an intriguing property of Silk is its innate piezoelectricity. This review highlights the importance of crystal orientation and structure of Silk Fibroin to display piezoelectric response and documents possible strategies for its enhancement. It also provides insight into the possibility of using piezoelectric Silk as a piezoelectric sensor, actuator, and energy harvester to form self‐powered hybrid systems for autonomous bioelectronics
The positive and negative sleep appraisal measure: Towards a clinical validation of sleep spectrum cognitions
Authors: Pearson Lydia , Parker Sophie , Mansell Warren 
Published: August 2021

AbstractBackgroundSleep disturbance is considered a transdiagnostic process due to high comorbidity with mental health difficulties. In particular, sleep disturbances are a feature of mood disorders. To advance transdiagnostic psychological interventions targeting sleep, the Positive and Negative Sleep Appraisal Measure (PANSAM) was developed. The PANSAM is a theory‐driven measure based on an Integrative Cognitive Sleep Model and proposes that positive and negative sleep appraisals for excessively long and short sleep durations play a key role in the development of insomnia, hypersomnia, and reduced need for sleep. This study evaluated clinical validity of this new measure.MethodsParticipants were those who met bipolar at risk criteria and bipolar diagnoses (bipolar spectrum group) (N = 22), major depressive disorder (unipolar depression group) (N = 18), and a nonclinical group (N = 22). To compare against previous insomnia and bipolar disorder relevant research, administered measures included the Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS) and the Hypomanic and Positive Predictions Inventory (HAPPI).ResultsAnalysis of variance (ANOVA) tests revealed that the clinical groups scored significantly higher on the PANSAM. The same was shown for the DBAS and HAPPI. Post hoc analyses showed that the PANSAM scale and subscales had significant correlations with all clinical measures. Effect sizes are reported due to sample size limitations.ConclusionThis study has initially validated the PANSAM with clinical populations and highlighted its applicability to a transdiagnostic approach.
Cost‐aware co‐locating of services in Internet of Things by using multicriteria decision making
Authors: Jamali Shahram , Abbasalizadeh Maryam 
Published: August 2021

SummaryInternet of Things (IoT) as an emerging technology is going to play a critical rule in the physical‐cyber ecosystem. In this environment, sensing and actuating are considered as services for building intelligent applications. From performance point of view, a main question is how to locate these services on devices can realize a remarkable cost‐efficiency and energy saving. In this paper, the goal is to specify which accompanying service with another specific service can be set on a device to optimize the energy consumption, load amount on devices, and the service response time. For this purpose, we formulate this goal as a multiobjective decision‐making problem, and then we solve it by using the PROMETHEE method. In this solution, the utility of each device is determined and estimated based on entropy technique that used for computing weights for different criteria. Numerical simulation results show that the proposed co‐locating algorithm, called p‐co‐locating, outperforms none‐co‐locating approach in terms of energy consumption, load amount, and the service response time.
Effective and transient mapping of protein–protein interactions: Application of novel releasable photoaffinity linkers
Authors: Wang Jin , Ma Yuexiang , Li Jing , Zhang Qingqing , Pan Xiaoyan , Lu Wen , Zhang Jie 
Published: August 2021

AbstractHerein, two novel multifunctional releasable photoaffinity linkers were developed for effective and transient tracking interacting proteins with the overall objective of understanding their in vivo biological functions in real‐time. These linkers could be used for the chemical modification of protein under moderate experimental conditions to form protein photoaffinity probes. These probes incorporated with both photoaffinity labels and tag‐transfer, enable photo‐crosslinking of bait proteins along with the release of unrelated groups. These photoaffinity linkers can be utilized to construct probes for disease markers, which could enable rapid diagnosis in a clinical setting at minimal interference with normal physiology.
Parental history of childhood maltreatment and child average RSA shape parent–child RSA synchrony
Authors: Fuchs Anna , Lunkenheimer Erika , Brown Kayla 
Published: August 2021

AbstractWe examined whether dynamic parent–child RSA synchrony varied by individual differences in child average RSA and parental history of childhood maltreatment (CM), which has been linked to parental behavioral and physiological dysregulation. We also examined whether RSA synchrony was curvilinear, reflecting homeostatic regulation. Synchrony was defined as the dynamic association between parent and child RSA reactivity (change relative to their own mean) within epoch across a challenging task. Eighty‐three mother–preschooler and 61 father–preschooler dyads participated. State‐trait modeling showed that RSA synchrony was curvilinear such that significant relations were only found at lower and higher child reactivity. Children's higher task average RSA predicted maternal RSA augmentation and lower task average RSA predicted maternal RSA withdrawal, regardless of whether child reactivity in the moment was low or high, suggesting individual differences in child regulatory capacity were associated with dynamic maternal reactivity. When maternal CM history and child average RSA were both higher, mothers showed RSA augmentation. Father–child synchrony was not moderated by child average RSA but greater paternal CM history predicted fathers’ greater RSA withdrawal regardless of whether child RSA reactivity was low or high. Findings offer novel insights into the nature and meaning of RSA synchrony with parents at risk.
Psychometric properties of infant electroencephalography: Developmental stability, reliability, and construct validity of frontal alpha asymmetry and delta–beta coupling
Authors: Anaya Berenice , Ostlund Brendan , LoBue Vanessa , Buss Kristin , Pérez‐Edgar Koraly 
Published: August 2021

AbstractResting‐state electroencephalography (EEG) provides developmental neuroscientists a noninvasive view into the neural underpinnings of cognition and emotion. Recently, the psychometric properties of two widely used neural measures in early childhood—frontal alpha asymmetry and delta–beta coupling—have come under scrutiny. Despite their growing use, additional work examining how the psychometric properties of these neural signatures may change across infancy is needed. The current study examined the developmental stability, split‐half reliability, and construct validity of infant frontal alpha asymmetry and delta–beta coupling. Infants provided resting‐state EEG data at 8, 12, and 18 months of age (N = 213). Frontal alpha asymmetry and delta–beta coupling showed significant developmental change from 8 to 18 months. Reliability for alpha asymmetry, and alpha, delta, and beta power, individually, was generally good. In contrast, the reliability of delta–beta coupling scores was poor. Associations between frontal alpha asymmetry and approach tendencies generally emerged, whereas stronger (over‐coupled) delta–beta coupling scores were associated with profiles of dysregulation and low inhibition. However, the individual associations varied across time and specific measures of interest. We discuss these findings with a developmental lens, highlighting the importance of repeated measures to better understand links between neural signatures and typical and atypical development.
Sociodemographics and chronic stress in mother–toddler dyads living in poverty
Authors: Bates Randi A. , Ford Jodi L. , Jiang Hui , Pickler Rita , Justice Laura M. , Dynia Jaclyn M. , Ssekayombya Prosper 
Published: August 2021

AbstractExperiencing chronic stress early in life is associated with later health disparities, and poverty may be a significant stressor for both mothers and children. With a sample of primarily Black and White mothers (N = 75) and toddlers (N = 71) living in poverty in the United States, we examined the direct relations between sociodemographic conditions of poverty and chronic physiological stress. Mothers completed questionnaires on sociodemographics, including mother/toddler race, mother's education, father's education, poverty level, economic hardship, marital status, unemployment status, and toddler sex. Physiological chronic stress was measured by assaying the cortisol content of 4 cm samples of hair cut from the posterior vertex of mothers and toddlers (20–24 months of age) to represent 4 months of stress. Mothers’ and toddlers’ chronic stress was significantly, moderately, and positively associated. Toddlers had a trending relationship of moderately higher chronic stress if they were Black compared to not Black. Mothers had significantly, moderately higher chronic stress if they were Black or had a Black toddler (compared to not Black), not married (compared to married), or were working (compared to not working). The findings suggest that these mothers, simultaneously navigating poverty and parenting a toddler, need resources to reduce chronic stress.
Longitudinal investigation of shyness and physiological vulnerability: Moderating influences of attention biases to threat and safety
Authors: Hassan Raha , Schmidt Louis A. 
Published: August 2021

AbstractShyness has long been identified as a vulnerability factor to developing psychosocial problems, but there is heterogeneity in these observed outcomes. One potential factor underlying these relations is individual differences in threat sensitivity. Using a longitudinal design, we examined whether attentional biases toward social threat and safety measured during adulthood moderated the association between shyness measured in emerging adulthood (N = 83, nfemale = 48; Mage = 23.56 years, SDage = 1.09 years) and frontal electroencephalogram (EEG) asymmetry at rest, a physiological index of vulnerability to psychopathology, measured nearly a decade later in adulthood (Mage = 31.68 years, SDage = 2.27 years). We found that only biases to threat moderated the association between shyness and resting frontal EEG asymmetry longitudinally. In individuals who displayed relative vigilance to social threat, shyness was associated with greater relative right frontal EEG activity at rest (i.e., increased physiological vulnerability). These findings suggest that attentional biases to threat may play a role in understanding the relation between shyness and some known physiological vulnerabilities to psychopathology in adults.
Stereospecific Synthesis of Conjugated Dienes by Carbenoid Eliminative Cross‐Coupling Using Lithiated Allylic Carbamates
Authors: Tanpure Subhash D. , Blakemore Paul R. 
Published: August 2021

Abstract1,2,4‐Trisubstituted 1,3‐butadienes were prepared in a stereocontrolled manner by carbenoid eliminative cross‐coupling between stereodefined lithiated secondary allylic carbamates and α‐carbamoyloxyalkyl boronates. All four geometric isomers of 4,7‐dimethyl‐1‐phenylocta‐3,5‐diene were stereospecifically generated [yields 44–73 %, dr (Δ3,4)=84 : 16 to 97 : 3] by appropriate combinations of (S,E)‐ or (S,Z)‐i‐PrCH=CHCLi(Me)OCb with (R)‐Ph(CH2)2CH(Bneo)OCb. A conjugated cyclohexenylidene and a model diene representing the C5‐C12 domain of cytotoxin callystatin A, were similarly elaborated in a stereochemically programmed manner. The configuration of the 1,2‐disubstituted alkene within the Li‐carbenoid was preserved in the diene product and the newly generated trisubstituted alkene component of the diene could be selectively installed in either (E)‐ or (Z)‐configuration by variation in carbenoid stereochemical pairing (like or unlike) and/or the mode of the elimination stage (syn or anti).
A novel structure preserving semi‐implicit finite volume method for viscous and resistive magnetohydrodynamics
Authors: Fambri Francesco 
Published: August 2021

AbstractIn this work we introduce a novel semi‐implicit structure‐preserving finite‐volume/finite‐difference scheme for the viscous and resistive equations of magneto‐hydrodynamics (VRMHD) based on an appropriate 3‐split of the governing PDE system, which is decomposed into a first convective subsystem, a second subsystem involving the coupling of the velocity field with the magnetic field, and a third subsystem involving the pressure‐velocity coupling. The nonlinear convective terms are discretized explicitly, while the remaining two subsystems accounting for the Alfvén waves and the magneto‐acoustic waves are treated implicitly. Thanks to this, the final algorithm is at least formally constrained only by a mild CFL stability condition depending on the velocity field of the pure hydrodynamic convection. To preserve the divergence‐free constraint of the magnetic field exactly at the discrete level, a proper set of overlapping dual (staggered) meshes is employed. The resulting linear algebraic systems are shown to be symmetric and therefore can be solved by means of an efficient standard matrix‐free conjugate gradient algorithm. The final scheme can be regarded as a novel shock‐capturing, conservative, and structure preserving semi‐implicit scheme for VRMHD. Several numerical tests are presented to show the main features of our novel divergence‐free semi‐implicit FV/FD solver: linear‐stability in the sense of Lyapunov is verified at a prescribed constant equilibrium solution; a second‐order of convergence is obtained for a smooth time‐dependent solution; shock‐capturing capabilities are proven against a standard set of stringent MHD shock‐problems; accuracy and robustness are verified against a non‐trivial set of two‐ and three‐dimensional MHD problems.
Covariate adjusted inference of parent‐of‐origin effects using case–control mother–child paired multilocus genotype data
Authors: Zhang Kai , Zhang Hong , Hochner Hagit , Chen Jinbo 
Published: August 2021

AbstractIt is of great interest to identify parent‐of‐origin effects (POEs) since POEs play an important role in many human heritable disorders and human early life growth and development. POE is sometimes referred to as imprinting effect in the literature. Compared with the standard logistic regression analyses, retrospective likelihood‐based statistical methods are more powerful in identifying POEs when data are collected from related individuals retrospectively. However, none of existing retrospective‐based methods can appropriately incorporate covariates that should be adjusted for if they are confounding factors. In this paper, a novel semiparametric statistical method, M‐HAP, is developed to detect POEs by fully exploring available information from multilocus genotypes of case–control mother–child pairs and covariates. Some large sample properties are established for M‐HAP. Finite sample properties of M‐HAP are illustrated by extensive simulation studies and real data applications to the Jerusalem Perinatal Study and the Danish National Birth Cohort study, which confirm the desired superiority of M‐HAP over some existing methods. M‐HAP has been implemented in the updated R package CCMO.
Role of primary tumor resection in patients with metastatic medullary thyroid cancer who have unresectable distant metastases
Authors: Zhuang Shi‐Min , Xie Liang‐En , Pang Feng , Zhong Qian‐Yi , Sun Xiao‐Mei , Wen Wei‐Ping , Liu Tian‐Run 
Published: August 2021

AbstractBackgroundWhether patients with medullary thyroid carcinoma (MTC) who have unresectable synchronous distant metastases should undergo primary surgical resection (PTR) remains controversial. This study aimed to identify predictive factors associated with the survival of such patients.MethodsWe conducted a retrospective study of patients with MTC who were registered in the Surveillance, Epidemiology, and End Results registry. The overall and cancer‐specific mortality rates were assessed using risk‐adjusted Cox proportional hazards regression modeling and stratified propensity score matching.ResultsOne hundred and eight matched patients were assessed. Patients in the PTR group had lower overall mortality than did those in the non‐PTR group. The 1‐, 3‐, and 5‐year overall and cancer‐specific survival rates in the PTR group were significantly higher.ConclusionsPTR appears to be the most appropriate intervention for patients with good performance status. Such patients are likely to benefit from surgery and to experience long‐term stable disease.
RGD‐pectin microfiber patches for guiding muscle tissue regeneration
Authors: Campiglio Chiara Emma , Carcano Anna , Draghi Lorenza 
Published: August 2021

AbstractOpportunely arranged microscaled fibers offer an attractive 3D architecture for tissue regeneration as they may enhance and stimulate specific tissue regrowth. Among different scaffolding options, encapsulating cells in degradable hydrogel microfibers appears as particularly attractive strategy. Hydrogel patches, in fact, offer a highly hydrated environment, allow easy incorporation of biologically active molecules, and can easily adapt to implantation site. In addition, microfiber architecture is intrinsically porous and can improve mass transport, vascularization, and cell survival after grafting. Anionic polysaccharides, as pectin or the more popular alginate, represent a particularly promising choice for the fabrication of cell‐laden patches, due to their extremely mild gelation in the presence of divalent ions and widely accepted biocompatibility. In this study, to combine the favorable properties of hydrogel and fibrous architecture, a simple coaxial flow wet‐spinning system was used to prepare cell‐laden, 3D fibrous patches using RGD‐modified pectin. Rapid fabrication of coherent self‐standing patches, with diameter in the range of 100–200 μm and high cell density, was possible by accurate choice of pectin and calcium ions concentrations. Cells were homogeneously dispersed throughout the microfibers and remained highly viable for up to 2 weeks, when the initial stage of myotubes formation was observed. Modified‐pectin microfibers appear as promising scaffold to support muscle tissue regeneration, due to their inherent porosity, the favorable cell–material interaction, and the possibility to guide cell alignment toward a functional tissue.
Ginsenoside Rg3 attenuates cisplatin‐induced kidney injury through inhibition of apoptosis and autophagy‐inhibited NLRP3
Authors: Zhai Jinghui , Gao Huan , Wang Shuo , Zhang Sixi , Qu Xiaoyu , Zhang Yueming , Tao Lina , Sun Jingmeng , Song Yanqing , Fu Li 
Published: August 2021

AbstractThe NOD‐like receptor family pyrin domain‐containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)‐induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng, is reported to protect against CP‐induced nephrotoxicity. However, the mechanisms underlying renoprotection by SY have not been established to date. Our results indicate that SY attenuated CP‐induced apoptosis and damage in vivo and in vitro, as evidenced by increased cell viability, decreased the proportion of late apoptotic cells, elevated mitochondrial membrane potential, and ameliorated histopathological damage of the kidney. SY ameliorated CP‐induced human renal tubular (HK‐2) cells and kidney injury through upregulation of LC3II/I and beclin‐1, inhibition of p62, NLRP3, ASC, caspase‐1, and interleukin‐1β. However, blockade of autophagy by 3‐methyladenine reversed the suppression of SY on NLRP3 inflammasome activation and the protection of SY on HK‐2 cells. Our collective results support the utility of SY as a therapeutic agent that effectively protects against CP‐induced kidney injury by activating the autophagy‐mediated NLRP3 inhibition pathway.