bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immersive virtual reality enables technical skill acquisition for scrub nurses in complex revision total knee arthroplasty
Authors: Edwards Thomas C. , Patel Arjun , Szyszka Bartosz , Coombs Alexander W. , Liddle Alexander D. , Kucheria Rakesh , Cobb Justin P. , Logishetty Kartik 
Published: July 2021

Abstract
Introduction
Immersive Virtual Reality (iVR) is a novel technology which can enhance surgical training in a virtual environment without supervision. However, it is untested for the training to select, assemble and deliver instrumentation in orthopaedic surgery—typically performed by scrub nurses. This study investigates the impact of an iVR curriculum on this facet of the technically demanding revision total knee arthroplasty.

Materials and methods
Ten scrub nurses completed training in four iVR sessions over a 4-week period. Initially, nurses completed a baseline real-world assessment, performing their role with real equipment in a simulated operation assessment. Each subsequent iVR session involved a guided mode, where the software taught participants the procedural choreography and assembly of instrumentation in a simulated operating room. In the latter three sessions, nurses also undertook an assessment in iVR. Outcome measures were related to procedural sequence, duration of surgery and efficiency of movement. Transfer of skills from iVR to the real world was assessed in a post-training simulated operation assessment. A pre- and post-training questionnaire assessed the participants knowledge, confidence and anxiety.

Results
Operative time reduced by an average of 47% across the 3 unguided sessions (mean 55.5 ± 17.6 min to 29.3 ± 12.1 min, p > 0.001). Assistive prompts reduced by 75% (34.1 ± 16.8 to 8.6 ± 8.8, p < 0.001), dominant hand motion by 28% (881.3 ± 178.5 m to 643.3 ± 119.8 m, p < 0.001) and head motion by 36% (459.9 ± 99.7 m to 292.6 ± 85.3 m, p < 0.001). Real-world skill improved from 11% prior to iVR training to 84% correct post-training. Participants reported increased confidence and reduced anxiety in scrubbing for rTKA procedures (p < 0.001).

Conclusions
For scrub nurses, unfamiliarity with complex surgical procedures or equipment is common. Immersive VR training improved their understanding, technical skills and efficiency. These iVR-learnt skills transferred into the real world.
Analysing the life index of diamond cutting tools for marble building stones based on laboratory and field investigations
Authors: Bahri Maziyar , Ghasemi Ebrahim , Kadkhodaei Mohammad Hossein , Romero-Hernández Rocío , Mascort-Albea Emilio J. 
Published: July 2021

AbstractCutting tool wear constitutes one of the principal parameters in the processing cost of building stone. The life index of the cutting tool is obtained by evaluating the wear of diamond segments in the processing plants and examining the main parameters thereof. The purpose of this study is to determine the life index of the diamond cutting tool by considering the physico-mechanical properties of marble stones and the operational parameter of cutting speed. To this end, a dataset was provided by collecting the data from eight building stone processing plants in the provinces of Tehran, Isfahan, and Yazd of Iran. In this regard, the number of square metres of building stone that every diamond cutting tool can cut during its lifetime is defined as the cutting tool life index (TLI). After collecting the required data, SPSS software was employed for statistical analysis. The results revealed that the Brazilian tensile strength is the main parameter that affects the cutting tool life index. Linear and non-linear regression analyses were then considered for the development of predictive models for the TLI based on the Brazilian tensile strength. The performance of the developed models was subsequently examined by using three different criteria: the coefficient of determination, the variance accounted for, and the root-mean-square error. The results of this study show that the non-linear predictive model of the TLI presents a very good performance, and thus, the diamond cutting tool life index can be obtained for marble stones by considering the model developed herein.
Psychological factors associated with headache frequency, intensity, and headache-related disability in migraine patients
Authors: Klonowski Theresa , Kropp Peter , Straube Andreas , Ruscheweyh Ruth 
Published: July 2021

Abstract
Background
Several psychological cofactors of migraine have been identified, but relationships to different headache parameters (e.g., headache frequency vs. headache-related disability) are only incompletely understood.

Methods
We cross-sectionally assessed 279 migraine patients at their first presentation at our tertiary headache center. We obtained headache and acute medication frequency, pain intensity, the Migraine Disability Assessment Scale (MIDAS), and the Pain Disability Index (PDI) as headache-related outcomes as well as scores of the Hospital Anxiety and Depression Scale (HADS), the Pain Catastrophizing Scale (PCS), Pain-Related Control Scale (PRCS), and Avoidance Endurance Questionnaire (AEQ) as psychological factors.

Results
Linear regression models revealed the highest associations of the psychological factors with the PDI (adjusted R2 = 0.296, p < 0.001, independent predictors: PCS, AEQ social avoidance, depression) followed by the MIDAS (adjusted R2 = 0.137, p < 0.001, predictors: depression, AEQ social avoidance) and headache frequency (adjusted R2 = 0.083, p < 0.001, predictors: depression, AEQ humor/distraction). Principal component analysis corroborated that psychological factors were preferentially associated with the PDI, while the MIDAS loaded together with headache frequency.

Conclusion
Our results suggest that psychological factors are more strongly associated with the subjective degree of headache-related disability measured by the PDI than with the days with disability (MIDAS) or the more objective parameter of headache frequency. This once again highlights the need for comprehensive assessment of migraine patients with different headache parameters and the need for considering psychological treatment, especially in patients with high disability.
Analysis of the spectral symbol associated to discretization schemes of linear self-adjoint differential operators
Authors: Bianchi Davide 
Published: July 2021

AbstractGiven a linear self-adjoint differential operator $$\mathscr {L}$$
L
along with a discretization scheme (like Finite Differences, Finite Elements, Galerkin Isogeometric Analysis, etc.), in many numerical applications it is crucial to understand how good the (relative) approximation of the whole spectrum of the discretized operator $$\mathscr {L}\,^{(n)}$$

L

(
n
)

is, compared to the spectrum of the continuous operator $$\mathscr {L}$$
L
. The theory of Generalized Locally Toeplitz sequences allows to compute the spectral symbol function $$\omega $$
ω
associated to the discrete matrix $$\mathscr {L}\,^{(n)}$$

L

(
n
)

. Inspired by a recent work by T. J. R. Hughes and coauthors, we prove that the symbol $$\omega $$
ω
can measure, asymptotically, the maximum spectral relative error $$\mathscr {E}\ge 0$$

E
≥
0

. It measures how the scheme is far from a good relative approximation of the whole spectrum of $$\mathscr {L}$$
L
, and it suggests a suitable (possibly non-uniform) grid such that, if coupled to an increasing refinement of the order of accuracy of the scheme, guarantees $$\mathscr {E}=0$$

E
=
0

.
Recent strategies in nanodelivery systems for natural products: a review
Authors: Vanti Giulia 
Published: July 2021

AbstractNatural products are major molecules for drug discovery due to their structural diversity and their interaction with various biological targets, yet their clinical application is limited by poor water solubility or low lipophilicity, inappropriate molecular size, low dissolution rate and permeation, instability, high metabolic rate and rapid clearance. These issues can be solved by nanomedicine, by improving bioavailability and therapeutic efficacy. Here we review nanocarriers made of polymer or lipid constituents. Specifically, we describe the technological characteristics of each nanosystem, with examples of application to single natural constituents or plant extracts, and possible routes of administration. We report in vitro and in vivo studies and we conclude with the potential advantages of nanodelivery systems in terms of increased stability and solubility, improved biodistribution and efficacy, reduced adverse effects and toxicity.
Modelling the damage costs of invasive alien species
Authors: Ahmed Danish A. , Hudgins Emma J. , Cuthbert Ross N. , Haubrock Phillip J. , Renault David , Bonnaud Elsa , Diagne Christophe , Courchamp Franck 
Published: July 2021

AbstractThe rate of biological invasions is growing unprecedentedly, threatening ecological and socioeconomic systems worldwide. Quantitative understandings of invasion temporal trajectories are essential to discern current and future economic impacts of invaders, and then to inform future management strategies. Here, we examine the temporal trends of cumulative invasion costs by developing and testing a novel mathematical model with a population dynamical approach based on logistic growth. This model characterises temporal cost developments into four curve types (I–IV), each with distinct mathematical and qualitative properties, allowing for the parameterization of maximum cumulative costs, carrying capacities and growth rates. We test our model using damage cost data for eight genera (Rattus,Aedes,Canis,Oryctolagus,Sturnus,Ceratitis,SusandLymantria) extracted from the InvaCost database—which is the most up-to-date and comprehensive global compilation of economic cost estimates associated with invasive alien species. We find fundamental differences in the temporal dynamics of damage costs among genera, indicating they depend on invasion duration, species ecology and impacted sectors of economic activity. The fitted cost curves indicate a lack of broadscale support for saturation between invader density and impact, including forCanis,OryctolagusandLymantria, whereby costs continue to increase with no sign of saturation. For other taxa, predicted saturations may arise from data availability issues resulting from an underreporting of costs in many invaded regions. Overall, this population dynamical approach can produce cost trajectories for additional existing and emerging species, and can estimate the ecological parameters governing the linkage between population dynamics and cost dynamics.
Change in mammography screening attendance after removing the out-of-pocket fee: a population-based study in Sweden (2014–2018)
Authors: Lagerlund Magdalena , Åkesson Anna , Zackrisson Sophia 
Published: July 2021

Abstract
Purpose
To assess the change in mammography screening attendance in Sweden—overall and in sociodemographic groups at risk of low attendance—after removal of the out-of-pocket fee in 2016.

Methods
Individual-level data on all screening invitations and attendance between 2014 and 2018 were linked to sociodemographic data from Statistics Sweden. Odds ratios and 95% confidence intervals (CIs) for attendance by time period and sociodemographic factor were computed using mixed logistic regression to account for repeated measures within women. The study sample included 1.4 million women, aged 40–75, who had a mammography screening appointment in 2014–2015 and/or 2017–2018 in 14 of Sweden’s 21 health care regions.

Results
Overall screening attendance was 83.8% in 2014–2015 and 84.1% in 2017–2018 (+ 0.3 percentage points, 95% CI 0.2–0.4). The greatest increase in attendance was observed in non-Nordic women with the lowest income, where attendance rose from 62.9 to 65.8% (+ 2.9 points, 95% CI 2.3–3.6), and among women with four or more risk factors for low attendance, where attendance rose from 59.2 to 62.0% (+ 2.8 points, 95% CI 2.2–3.4).

Conclusion
Screening attendance did not undergo any important increase after implementing free screening, although attendance among some sociodemographic groups increased by almost three percentage points after the policy change.
When intuition falters: repeated testing accuracy during an epidemic
Authors: Hay James A. , Hellewell Joel , Qiu Xueting 
Published: July 2021

AbstractWidespread, repeated testing using rapid antigen tests to proactively detect asymptomatic SARS-CoV-2 infections has been a promising yet controversial topic during the COVID-19 pandemic. Concerns have been raised over whether currently authorized lateral flow tests are sufficiently sensitive and specific to detect enough infections to impact transmission whilst minimizing unnecessary isolation of false positives. These concerns have often been illustrated using simple, textbook calculations of positivity rates and positive predictive value assuming fixed values for sensitivity, specificity and prevalence. However, we argue that evaluating repeated testing strategies requires the consideration of three additional factors: new infections continue to arise depending on the incidence rate, isolating positive individuals reduces prevalence in the tested population, and each infected individual is tested multiple times during their infection course. We provide a simple mathematical model with an online interface to illustrate how these three factors impact test positivity rates and the number of isolating individuals over time. These results highlight the potential pitfalls of using inappropriate textbook-style calculations to evaluate statistics arising from repeated testing strategies during an epidemic.
The role of Caenorhabditis elegans sex-determination homologs, Mi-sdc-1 and Mi-tra-1 in Meloidogyne incognita
Authors: Baniya Anil , Joseph Soumi , Duncan Larry , Crow William , Mengistu Tesfamariam 
Published: July 2021

AbstractSex determination is a key developmental event in all organisms. The pathway that regulates sexual fate has been well characterized at the molecular level in the model free-living nematode Caenorhabditis elegans. This study aims to gain a preliminary understanding of sex-determining pathways in a plant-parasitic nematode Meloidogyne incognita, and the extent to which the roles of the sex determination genes are conserved in a hermaphrodite species, C. elegans, and plant-parasitic nematode species, M. incognita. In this study, we targeted two sex-determining orthologues, sdc-1 and tra-1 from M. incognita using RNA interference (RNAi). RNAi was performed by soaking second-stage juveniles of M. incognita in a solution containing dsRNA of either Mi-tra-1or Mi-sdc-1 or both. To determine the effect of RNAi of the target genes, the juveniles treated with the dsRNA were inoculated onto a susceptible cultivar of cowpea grown in a nutrient pouch at 28 °C for 5 weeks. The development of the nematodes was analyzed at different time points during the growth period and compared to untreated controls. Our results showed that neither Mi-sdc-1 nor Mi-tra-1 have a significant role in regulating sexual fate in M. incognita. However, the silencing of Mi-sdc-1 significantly delayed maturity to adult females but did not affect egg production in mature females. In contrast, the downregulation of Mi-tra-1 transcript resulted in a significant reduction in egg production in both single and combinatorial RNAi-treated nematodes. Our results indicate that M. incognita may have adopted a divergent function for Mi-sdc-1 and Mi-tra-1distinct from Caenorhabditis spp. However, Mi-tra-1 might have an essential role in female fecundity in M. incognita and is a promising dsRNA target for root-knot nematode (RKN) management using host-delivered RNAi.
Volumetric study reveals the relationship between outcome and early radiographic response during bevacizumab-containing chemoradiotherapy for unresectable glioblastoma
Authors: Takigawa Kosuke , Hata Nobuhiro , Michiwaki Yuhei , Hiwatashi Akio , Yonezawa Hajime , Kuga Daisuke , Hatae Ryusuke , Sangatsuda Yuhei , Fujioka Yutaka , Funakoshi Yusuke , Otsuji Ryosuke , Sako Aki , Togao Osamu , Yoshiura Takashi , Yoshimoto Koji , Mizoguchi Masahiro 
Published: July 2021

Abstract
Purpose
Although we have shown the clinical benefit of bevacizumab (BEV) in the treatment of unresectable newly diagnosed glioblastomas (nd-GBM), the relationship between early radiographic response and survival outcome remains unclear. We performed a volumetric study of early radiographic responses in nd-GBM treated with BEV.

Methods
Twenty-two patients with unresectable nd-GBM treated with BEV during concurrent temozolomide radiotherapy were analyzed. An experienced neuroradiologist interpreted early responses on fluid-attenuated inversion recovery (FLAIR) and gadolinium-enhanced T1-weighted images (GdT1WI). Volumetric changes were evaluated using diffusion-weighted imaging (DWI) and GdT1WI according to the Response Assessment in Neuro-Oncology (RANO) criteria. The results were categorized into improved (complete response [CR] or partial response [PR]) or non-improved (stable disease [SD] or progressive disease [PD]) groups; outcomes were compared using Kaplan–Meier analysis.

Results
The volumetric GdT1WI improvement was a significant predictive factor for overall survival (OS) prolongation (p = 0.0093, median OS: 24.7 vs. 13.6 months); however, FLAIR and DWI images were not predictive. The threshold for the neuroradiologist’s interpretation of improvement in GdT1WI was nearly 20% of volume reduction, which was lesser than 50%, the definition of PR applied in the RANO criteria. However, even less stringent neuroradiologist interpretation could successfully predict OS prolongation (improved vs. non-improved: p = 0.0067, median OS: 17.6 vs. 8.3 months). Significant impact of OS on the early response in volumetric GdT1WI was observed within the cut-off range of 20–50% (20%, p = 0.0315; 30%, p = 0.087; 40%, p = 0.0456).

Conclusions
Early response during BEV-containing chemoradiation can be a predictive indicator of patient outcome in unresectable nd-GBM.
A general framework for modeling and dynamic simulation of multibody systems using factor graphs
Authors: Blanco-Claraco Jose-Luis , Leanza Antonio , Reina Giulio 
Published: July 2021

AbstractIn this paper, we present a novel general framework grounded in the factor graph theory to solve kinematic and dynamic problems for multibody systems. Although the motion of multibody systems is considered to be a well-studied problem and various methods have been proposed for its solution, a unified approach providing an intuitive interpretation is still pursued. We describe how to build factor graphs to model and simulate multibody systems using both, independent and dependent coordinates. Then, batch optimization or a fixed lag smoother can be applied to solve the underlying optimization problem that results in a highly sparse nonlinear minimization problem. The proposed framework has been tested in extensive simulations and validated against a commercial multibody software. We release a reference implementation as an open-source C++ library, based on the GTSAM framework, a well-known estimation library. Simulations of forward and inverse dynamics are presented, showing comparable accuracy with classical approaches. The proposed factor graph-based framework has the potential to be integrated into applications related with motion estimation and parameter identification of complex mechanical systems, ranging from mechanisms to vehicles, or robot manipulators.
Young People’s Well-Being and the Association with Social Capital, i.e. Social Networks, Trust and Reciprocity
Authors: Tuominen Minna , Haanpää Leena 
Published: July 2021

AbstractThe paper explores the association between social capital of young people at 12–13 years and their subjective well-being using Finland’s sub-sample of the third wave of the International Survey of Children’s Well-Being. Despite much previous research on this topic, relatively little knowledge is accumulated given that different studies define and measure social capital differently. In line with Robert Putnam, we understand social capital as a combination of social networks, trust, and norms of reciprocity. We measure well-being with two context-free scales: a one-dimensional overall life satisfaction scale and a five-dimensional Student’s life satisfaction scale. The analysis is done with linear and unconditional quantile regression. The results indicate that all three dimensions of social capital are significantly associated with well-being. Of the three, trust is the strongest predictor explaining over 30% of the variance in both well-being scales. The study demonstrates the relevance of considering all dimensions of social capital together to avoid unobserved variable bias. Quantile regression reveals that while social capital is important for well-being across the quantiles, it is particularly important for the youth who fare poorly otherwise. Family-related variables showed the strongest association with well-being while relationships with friends, schoolmates, teachers, and other people mattered considerably less.
Testing the extraction of 12 mycotoxins from aqueous solutions by insoluble beta-cyclodextrin bead polymer
Authors: Mohos Violetta , Faisal Zelma , Fliszár-Nyúl Eszter , Szente Lajos , Poór Miklós 
Published: July 2021

AbstractMycotoxins are toxic metabolites of filamentous fungi; they are common contaminants in numerous foods and beverages. Cyclodextrins are ring-shaped oligosaccharides, which can form host-guest type complexes with certain mycotoxins. Insoluble beta-cyclodextrin bead polymer (BBP) extracted successfully some mycotoxins (e.g., alternariol and zearalenone) from aqueous solutions, including beverages. Therefore, in this study, we aimed to examine the ability of BBP to remove other 12 mycotoxins (including aflatoxin B1, aflatoxin M1, citrinin, dihydrocitrinone, cyclopiazonic acid, deoxynivalenol, ochratoxin A, patulin, sterigmatocystin, zearalanone, α-zearalanol, and β-zearalanol) from different buffers (pH 3.0, 5.0, and 7.0). Our results showed that BBP can effectively extract citrinin, dihydrocitrinone, sterigmatocystin, zearalanone, α-zearalanol, and β-zearalanol at each pH tested. However, for the removal of ochratoxin A, BBP was far the most effective at pH 3.0. Based on these observations, BBP may be a suitable mycotoxin binder to extract certain mycotoxins from aqueous solutions for decontamination and/or for analytical purposes.
Influence of plastic fines content on the liquefaction susceptibility of sands: monotonic loading
Authors: Goudarzy Meisam , Sarkar Debdeep , Lieske Wolfgang , Wichtmann Torsten 
Published: July 2021

AbstractThe paper presents an experimental study on the effect of plastic fines content on the undrained behavior and liquefaction susceptibility of sand–fines mixtures under monotonic loading. The results of undrained monotonic triaxial compression tests conducted on mixtures of Hostun sand with varying amount (0–20%) and type (kaolin and calcigel bentonite) of plastic fines are presented. The specimens were prepared with different initial densities using the moist tamping method and consolidated at two different isotropic effective stresses. The results demonstrate that for both types of plastic fines, an increase in the fines content leads to a more contractive response and lower values of mobilized deviatoric stress. Despite similar relative density and fines content, the sand–kaolin mixtures showed a more contractive behavior than the sand–calcigel specimens. The steady-state lines (SSLs) ine–p´ space generally move downwards with increasing clay content. While the slopes of the SSLs for the clean Hostun sand and the mixtures with 10 and 20% kaolin are quite similar, the SSL lines for the specimens containing 10% or 20% calcigel run steeper or flatter, respectively. The inclination of the SSL in theq–p′ plane was found independent of clay type and content. The sand–kaolin mixtures were observed to be more susceptible to instability and flow liquefaction than the sand–calcigel mixtures.