bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Peningkatan Mutu Pelayanan Perpustakaan Madrasah Aliyah Negeri (MAN) 3 Palembang
Authors: Saputra Ade Akhmad , Syafi'i Syafi'i , Zainuri Ahmad , Ibrahim Duski 
Published: June 2021

Penelitian ini bertujuan untuk menganalisis strategi peningkatan mutu layanan perpustakaan di MAN 3 Palembang dan menganalisis karakteristik strategi peningkatan mutu layanan perpustakaan di MAN 3 Palembang. Penelitian ini merupakan penelitian kualitatif, adapun yang menjadi sumber primer dalam penelitian ini berjumlah 3 orang, yakni kepala perpustakaan, dua orang pengelola perpustakaan. Adapun teknik analisis data menggunakan metode analisis mengunakan Model Miles dan Huberman yang terdiri dari tiga tahapkan yaitu: reduksi data, tampilan data, dan gambar kesimpulan atau verifikasi. Berdasarkan hasil penelitian dan pembahasan, maka untuk strategi peningkatan mutu layanan perpustakaan di MAN 3 Palembang ada lima strategi yang dilakukan, yaitu; Realiabilitas, memberikan layanan perpustakaan sesuai dengan SOP perpustakaan. Daya tangggap, merespon permintaan pemustaka. Jaminan, akses layanan dengan mudah. Empati, pengelola perpustakaan berusaha berpikir untuk bisa memahami kebutuhan pemustaka. Bukti fisik, menata dan merawat sarana prasarana agar suasana nyaman. Ciri dari strategi peningkatan mutu layanan perpustakaan di MAN 3 Palembang, yaitu: Pertama, Fokus dari strategi peningkatan mutu layanan perpustakaan adalah pengembangan koleksi, promosi layanan dan buku baru. Kedua, Keunikan pada program book lover, program promosi, layanan infak buku, dan layanan pendampingan diperuntukkan kepada siswa yang akan mengikuti olimpiade dan perlombaan di luar sekolah. Ketiga, perpustakaan memiliki nama Baitul Hikmah dan slogan-slogan yang menarik.
Pengaruh Model Pembelajaran Snowball Throwing terhadap Motivasi Belajar Siswa Pendidikan Agama Islam di SMPN 1 Kotabaru
Authors: Aliyah Gina Himatul , Darmiyanti Astuti , Aisyah Dewi Siti 
Published: June 2021

Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh model pembelajaran snowball throwing terhapad motivasi belajar siswa pada mata pelajaran PAI. Metode yang digunakan adalah menggunakan metode penelitian Kuantitatif. Hasil penelitian tersebut menentukan bahwa Ada Pengaruh yang signifikan antara Variabel model pembelajaran snowball throwing terhadap motivasi belajar siswa pada mata pelajaran PAI di SMP N 1 Kotabaru. Hal ini dapat di ketahui dari analisis data secara menyeluruh. Berdasarkan Uji hipotesis asosiatif atau hubungan dua variabel yang datanya bersekala interval atau rasio maka menggunakan korelasi Product Moment dengan menggunakan SPSS tipe 16.0 hasil perhitungan dari 40 siswa kelas VII sebesar 0,732 dengan nilai p=0,000 hal ini menunjukkan bahwa hubungan kedua varibel tersebut kuat, yaitu berada pada interval 0,600-0,799. Dengan demikian dapat disimpulkan bahwa hipotesis yang diajukan diterima. Artinya terdapat pengaruh model pembelajaran snowball throwing terhadap motivasi belajar siswa pada mata pelajaran PAI di SMP N 1 Kotabaru. Hal ini dibuktikan Dengan derajat pengaruh sebesar 46,5% artinya masih terdapat 53,5% faktor lain yang bisa mempengaruhi atau memberikan kontribusi kepada motivasi belajar siswa.
Mulyasa, E. 2016. Menjadi Guru Profesional. Bandung: PT Remaja Rosdakarya.
UU RI Nomor 20/2003 Tentang Sistem Pendidikan Nasional 2003. Jakarta: Cemerlang.
Padjrin, P. (2016). Pola Asuh Anak dalam Perspektif Pendidikan Islam. Jurnal Intelektualita: KeIslaman, Sosial Dan Sains, 5(1), 1 - 14. https://doi.org/https://doi.org/10.19109/intelektualita.v5i1.720
Zaini, H., Hadi, A., Sofyan, F. A., & Hamzah, A. (2021). Covid-19 and Islamic Education in School: Searching for Alternative Learning Media. Webology, 18(1).
Suprijono, Agus. Cooperative Learning. Yogyakarta: Pustaka Belajar. 2012.
Implementasi Manajemen Kurikulum 2013 di SMP IT Az-Zhahiriah
Authors: Ulviana Iqrimah Silvi , Abubakar Abubakar , Ramdhani Khalid 
Published: June 2021

Penelitian ini bertujuan untuk mengetahui implementasi Kurikulum 2013 di SMP IT Az-Zhahiriah dalam upaya meningkatkan mutu pendidikan Islam. Metode penelitian yang digunakan adalah metode deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan metode wawancara, observasi dan studi dokumentasi. Teknik analisis data dengan mereduksi data dan penyajian data dalam bentuk naratif. Penelitian ini menunjukkan bahwa 1) perencanaan kurikulum 2013 di SMP IT Az-Zhahiriah terbagi menjadi dua yaitu perencanaan kurikulum internal dan eksternal. Perencanaan internal meliputi a) penyusunan perangkat pembelajaran; b) pembuatan kalender akademik; c) menganalisa kebutuhan guru, mengintegrasikan kurikulum umum dan tahfiz, menyesuaikan dengan silabus yang ditetapkan oleh Dinas Pendidikan. Sedangkan perencanaan eksternal yaitu dengan mengundang pengawas untuk sosialisasi terkait perangkat pembelajaran; dan 2) evaluasi manajemen kurikulum dilakukan dengan a) evaluasi input yang meliputi alokasi waktu evaluasi mingguan, semester, dan tahunan; b) evaluasi proses yang meliputi pembahasan evaluasi dimana dalam pembahasan evaluasi yaitu yang berkaitan dengan permasalahan-permasalahan yang belum tuntas tentang perangkat pembelajaran dan penyebaran angket ke siswa; dan c) evaluasi output yang meliputi perbaikan kurikulum kedepannya.
DIGITAL IMAGE AUTHENTICATION MODEL
Authors: Ruban Igor , Bolohova Nataliia , Martovytskyi Vitalii , Koptsev Oleh 
Published: June 2021

The development of new technologies, the growing volume of data and the total consumption of content in the digital environment are changing the ecosystem of modern media. Data can be easily and completely duplicated. It brings great convenience to life, work, scientific research and other areas of human activity. However, information security issues have appeared that have attracted a lot of attention. The purpose of this article is to present a model for digital image authentication. This article proposes a model for reliable verification of digital image authenticity with a high degree of protection and parameters for assessing the effectiveness of such systems. Reliability is achieved because the watermark is hidden not in the whole image, but in its fragment, which is most suitable for hiding the image, as well as for using anti-noise codes as a watermark. Based on the current state of watermarking methods, it is recommended to use modern algorithms and architectures of convolutional neural networks to ensure a high degree of security.
A Delphi consensus to advance on a Clinical Case Definition for Post COVID-19 condition: A WHO protocol
Authors: Diaz Janet V , Soriano Joan B 
Published: June 2021

Abstract
Background: While most people developing COVID-19 recover quickly and completely, a proportion of those infected with SARS-CoV-2 develop persistent symptoms, which can be disabling. After establishing the interim nomenclature for Post COVID-19 condition, there is a need to establish a clinical case definition to be used by all parties in all settings. Of the many definitions available to date, none is universal and the WHO has engaged in formally defining the Post COVID-19 condition based on existing evidence and by means of the most robust methodology. A key element for success is to engage patients and advocacy groups in this exercise.The objective of the study “Delphi consensus to advance on a Clinical Case Definition for Post COVID-19 condition” is to determine the domains, variables and values (thresholds) for inclusion into a clinical case definition for Post COVID-19 condition, using a Delphi consensus methodology. Methods: This study is a prospective, Delphi consensus-seeking exercise, mixed, iterative survey of internal and external experts, patients and other stakeholders. Panelists (individual participants who will fill the online survey in) will fulfil the criteria of balanced representativity of all WHO regions, age and gender balance, specialty diversity, and patients.We aim to sample approximately 100 panelists for this Delphi task, and the COMET Initiative DelphiManager software will be used. DelphiManager is a web-based system designed to facilitate the building and management of Delphi surveys.From an initial, comprehensive list of 14 domains identified, 10 have been selected, some of them with a number of sub-domains. It is envisaged that panelists will reach consensus after two Delphi rounds. The questionnaire with all agreed domains/variables will be followed by a series of questions relating to these variables with eventual values/thresholds (Appendix 2). Registration of panelists and the actual Delphi questionnaire are accessible via this link https://delphimanager.liv.ac.uk/DefiningPostCOVID/Delphi‘Consensus’ will be obtained on a question if 70% or more of the responses fall within the same response on a 9-point Likert scale. ‘Disagreement’ will occur if 35% or more of responses fall in both of the two extreme ranges of possible options on the Likert scale. All other combinations of panel answers will be considered ‘partial agreement’. Discussion: Establishing a satisfactory clinical case definition of Post COVID-19 condition is needed to enable systematic investigations of the incidence, duration and pathogenesis of Post COVID-19 condition, and to eventually develop effective treatments and successful management strategies and care pathways. This working clinical case definition may change as new evidence emerges, data are pooled and our understanding of the consequences of COVID-19 develops further.
Measuring flavin mononucleotide concentrations in whole blood, red cell based or acellular perfusate samples by fluorescence spectrometry
Authors: Wylin Tine , Heedfeld Veerle , Jochmans Ina 
Published: June 2021

Abstract
Flavin mononucleotide (FMN) is non-covalently bound to complex I of the mitochondrial respiratory chain. During ischemia-reperfusion injury, reduced FMN is released from complex I, leaving the complex impaired. In literature, FMN measured during ex situ organ perfusion has been considered as a biomarker for organ graft quality. With this protocol the FMN concentrations in perfusate samples taken during organ perfusion can be estimated quickly and easily by fluorescence spectrometry. The use of non-binding plates is essential. A fresh standard curve using riboflavin 5'-monophosphate sodium salt hydrate must be prepared every day. To quantitatively compare sample concentrations between different plates, it is advisable to include an internal standard. This internal standard is best prepared by pooling samples from experiments that use the same perfusate composition. This assay will work for samples acquired from whole blood, red cell based solutions or acellular solutions.
Possibly Appropriate Maintenance dose of Voriconazole in pediatric patients: a single center observational study
Authors: Zhao Yi-Chang , Zou Yang , Tang Dan , Xiao Chen-Lin , Xiao Yi-Wen , Wang Feng , Zhang Bi-Kui , Xiang Da-Xiong , Yu Feng , Yan Miao 
Published: June 2021

Abstract
Background: Voriconazole is a triazole antifungal agent and a commonly used first-line treatment for invasive aspergillosis (IA). The study was performed to explore the factors affecting voriconazole trough concentration and maintenance dose to optimize voriconazole dosage in pediatric patients. Method: The demographic information, concentration data, CYP2C19 genotypes, and clinical outcomes of eligible pediatric patients from January 1th, 2016 to December 31th, 2018 were collected retrospective . Result: The study finally included 145 voriconazole trough concentrations from 94 pediatric patients. Steady trough concentration ranged from 0.04 to 16.11 μg/mL. Morerover, the distinction between the maximum and the minimum corrected concentration of per kilogram maintenance dosage is as high as 907 folds and children ≤2 years old showed the minimum variation compared to other individuals (P<0.001). A high inter- and intra-individual variability of voriconazole in pediatric patients were observed. Only 54.5% of the pediatric patients achieved the target range (1.0 to 5.5 μg/mL) at unadjusted initial dosage, while 35.9% of children were subtherapeutic, only 9.6% of children were supratherapeutic at unadjusted initial dosing. The younger children (≤12 years) seem to have a lower trough concentration (P=0.0096) and lower percentage of target achievements (P=0.004). And 98.97% of the maintenance dosage was below 9.0 mg/kg. For pediatric patients of different ages, it was found that most of them was underdosed. While, to achieve targeted therapeutic level for different age groups of ≤2, 2-6, 6-12, and 12-18 years, the median voriconazole maintenance doses were 5.7, 6.7, 5.0, and 3.3 mg-1kg/12h, respectively had been required in order to achieve therapeutic level (P<0.001). Conclusion: Pediatric patients especially those ≤12 years old might need a higher dosage regime to achieve therapeutic trough concentration. Importantly, early and repeat monitoring of voriconazole is essential to ensure the effectiveness and safety of voriconazole in children.
Successful Treatment of stage IIIb intrahepatic Cholangiocarcinoma After Neoadjuvant Therapy With PD-1blockade Camrelizumab: A Case Report and Review of Literature
Authors: Zhu Shuguang , Li Haibo , Zhang Jianwen , Qiu Chunhui , Dai Tianxing , Li Hua , Wang Guoying 
Published: June 2021

Abstract
Prognosis of ICC with lymph node metastasis is poor. And the feasibility of operation is uncertain, which is a contraindication in NCCN guidelines. In addition, in the neoadjuvant therapy of ICC, the role of immunotherapy is not clear. We describe a case of ICC with lymph node metastasis was successfully treated with neoadjuvant therapy.
Title: E-cigarettes and smoking in Irish teens: A logistic regression analysis of current (past 30-day) use of e-cigarettes
Authors: Hanafin Joan , Sunday Salome , Clancy Luke 
Published: June 2021

Abstract
Aim: Electronic cigarette use among Irish teenagers has risen significantly. In 2019, prevalence of current use (last 30 days) among 15-17-year olds was 17.3%. We examine social determinants of adolescent e-cigarette current use. Subject and Methods: A stratified random sample of 50 schools in Ireland was surveyed in 2019, part of the European School Survey Project on Alcohol and other Drugs (ESPAD), with 3,495 students aged 15, 16 and 17. Bivariate and multivariable logistic regression (providing adjusted odds ratios (AORs)) analyses were performed using Stata version 16. Results: Current e-cigarette users were more likely to be male (AOR=0.55, 95% CI:0.32-0.96, p<.01), younger (AOR=0.34, 95% CI:0.17-0.67, p=<.05), to participate in sport (AOR=2.21, 95% CI:1.05-4.65, p<.05), to have higher-educated parents (maternal higher education: AOR=27.54, 95% CI:1.50-505.77, p=<.05, paternal higher education: AOR=2.44, 95% CI:1.00-5.91, p<.05), and less likely to consider their families better off (AOR=0.29, 95% CI:0.13-0.65, p<.01), or to report familial support (AOR=0.78, 95% CI:0.64-0.95, p<.05). They were more likely to be cigarette smokers (AOR=7.22, 95% CI:3.97-13.12, p<.001), to report problem cannabis use (AOR=3.12, 95% CI:1.40-6.93, p<.01), to be ‘binge’ drinkers (AOR=1.81, 95% CI:1.00-3.32, p=.054), and to have friends who get drunk (AOR=5.30, 95% CI:1.34-20.86, p<.05). Conclusion: Boys, smokers, binge drinkers, problem cannabis users, and sport-playing teenagers from higher-educated families, are at particular risk. As the number of young people using e-cigarettes continues to rise, including teenagers who have never smoked, improved regulation of e-cigarettes, similar to other tobacco-related products, is needed urgently to prevent this worrying new trend of initiation into nicotine addiction.
Establishment of callus induction system, histological evaluation and taxifolin production of Larch
Authors: Liu Xinglong , Zhao Yingchun , Chen Xueyan , Dong Ling , Zheng Yinan , Wu Ming , Ding Qiteng , Xu Shuang , Ding Chuanbo , Liu Wencong 
Published: June 2021

Abstract
Taxifolin in larch is an important natural active ingredient, which prevents and treats liver diseases and cardiovascular diseases, and has many health benefits and application values ​​such as anti-tumor, anti-virus, and anti-aging. However, the traditional extraction method is not conducive to the protection of the ecological environment, and also limits the industrial production of taxifolin from larch. Therefore, the purpose of this research is to establish a larch callus culture system and obtain taxifolin from callus. The shoots of the stem-tips of Larix olgensis were used as explants to be cultured. The light conditions, optimal medium and hormone ratio for callus induction were screened to evaluate the callus induction characteristics of larch and its influence on the accumulation of taxifolin. The results showed that: callus formation started on 28–51 days, and the best conditions for inducing callus were explored: 12 h/d light culture MS + 2,4-D 2 mg/L + 6-BA 1 mg/ L + KT 0.1 mg/L; the callus induction rate is 50%-80%; the highest condition for producing taxifolin 6-BA 1 mg/L + NAA 0.1 mg/L, reaching 0.414%. In conclusion, this study represents a suitable induction condition for larch callus culture and taxifolin accumulation.
Multi-Transcriptomic Analysis Points to Early Organelle Dysfunction in Human Astrocytes in Alzheimer’s Disease
Authors: Galea Elena , Weinstock Laura D. , Larramona-Arcas Raquel , Pybus Alyssa F. , Giménez-Llort Lydia , Escartin Carole , Wood Levi B. 
Published: June 2021

Abstract
BackgroundRecent gene profiling of human AD astrocytes using single-nucleus RNA sequencing is limited by the low number of differentially expressed genes detected, and the small size of cohorts. We improved on prior studies with a novel systems-biology-based approach that can be used with available data from large cohorts.Methods Brain-cell specific gene clusters were generated from RNA sequencing data from isolated healthy human brain cells using a cell-type enrichment score and clustering. The cell-specific gene clusters were localized in whole-brain transcriptomes from 766 subjects diagnosed with AD or mild cognitive impairment (MCI) by the Mount Sinai Hospital, the Mayo Clinic, and the Religious Order Study/Memory and Aging Project (ROSMAP). Gene clusters were organized into functional categories, and changes among subject groups determined by gene set variation analysis (GSVA) and principal component analysis (PCA).ResultsHierarchical clustering revealed molecular heterogeneity in individuals with the same clinical diagnosis. Particularly in the Mayo Clinic and ROSMAP cohorts, over 50% of Controls presented massive down-regulation of genes encoding synaptic proteins as described in AD, and 30% of AD patients looked like true Controls. The astrocytic gene profiles in AD patients presenting down-regulation of neuronal genes were termed ‘AD astrocytes’. According to GSVA and PCA, AD astrocytes showed down-regulation of genes encoding for mitochondrial and endolysosomal proteins, and up-regulation of genes related to perisynaptic astrocytic processes (PAP), and survival and stress responses. One limitation of the analysis is that gene clusters identified in healthy brain transcriptomes may no longer exist in AD. However, quantification of network reorganization in AD subjects using the metric ‘modular differential connectivity’ showed equal or enhanced connectivity in 95.5% of the modules, suggesting that clusters identified by co-expression analyses in healthy cells are preserved in AD. Another limitation is that changes in transcripts ubiquitous in all cell types may go undetected in our analysis relying on astrocyte-specific genes.DiscussionWe detected a profound transcriptional change in astrocytes in a high percentage of Control, MCI and AD subjects, affecting organelles and astrocyte-neuron interactions. We argue that therapies preventing organelle dysfunction in astrocytes may protect neural circuits in preclinical and clinical AD.
Isolated Adrenocorticotropic Hormone Deficiency Accompanied by Impaired Cognitive Function: A Case Report
Authors: IKENOUCHI ATSUKO , Seki Issei , Okamoto Naomichi , Konishi Yuki , Yoshimura Reiji 
Published: June 2021

Abstract
Background: Isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) is an adrenal insufficiency caused by a decrease in ACTH alone among the anterior pituitary hormones. IAD is often overlooked because it causes nonspecific symptoms. We report a case of IAD diagnosed after the appearance of mild cognitive impairment (MCI).Case presentation: Our department was consulted on a case of a 46-year-old man for whom dementia was suspected because he was speaking incoherently, wiped his nose with his hands and showed mild brain atrophy on MRI. He was previously diagnosed with some psychiatric diseases, such as narcolepsy and adjustment disorder. He could not continue working due to somnolence, general fatigue and appetite loss. At the examination, he had difficulty concentrating and sustaining attention, exhibited restlessness, and scored 25 points on the Mini Mental State Examination-Japanese (MMSE-J); MCI was observed. Blood tests showed decreased ACTH, cortisol and free thyroxine and increased thyroid-stimulating hormone levels. He received further evaluation, and he was diagnosed with IAD and primary hypothyroidism. Hydrocortisone (15 mg) was started, after which his physical problems and his difficulty concentrating disappeared. His MMSE-J score also increased to 30. His cognitive functions completely recovered. He returned to work and continued to work stably.Conclusion: This patient was diagnosed with IAD and treated with adrenocortical hormone replacement therapy. His cognitive functions recovered, his physical and mental disorders were alleviated, and he returned to society. It is important not to miss neurological and psychiatric symptoms that can be cured by physical treatment.
How does Foreign Direct Investment Influence the Environment in China? Prior and During the Covid-19 Pandemic
Authors: Salem Sultan , Kam Sanda , Lee Nicole 
Published: June 2021

Abstract
This study revisits the recent widely ongoing debate over the effects of FDI on the environment in China. Analysis has shown that firms seek to operate in countries with lax environmental standards, namely the PHV. However, the PHL counterargument is also prevalent. This theory stipulates FDI will bring higher environmental management standards and cleaner technologies into the host country. Empirical literature is inconclusive and at times conflicting between some hypotheses therefore this study aims to provide additional clarity on the impact of FDI on the environment in China. This study concludes the existence of both PHV and PHL hypotheses which can be explained by the impact mechanisms of FDI; scale, structural, technique and income effects. The development levels of China using the EKC model hypothesis is used to explain the varying impacts of FDI on the environment. Reflecting on these interesting recent findings in this study, policy implications are discussed and suggestions are provided to improve the impact of FDI on the environment. The future for China is expected to embody an environmental focus in promoting FDI in renewable energy and greener technologies to improve environmental quality.