bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salvia miltiorrhiza Ameliorates Disease Progression in Dextran-Sodium-Sulfate Induced Colitis in Mice
Authors: Chen Juan , Chen Danyu , Cheng Lu , Yang YongKang , Gu Weidong , Qin Dajiang , Wang Bin , Li Gang 
Published: October 2021

Abstract
Salvia miltiorrhiza (SM, or Danshen) extract has been approved by China FDA for the treatment of cardiovascular and cerebrovascular diseases owing to its potent anti-inflammatory effects. Whether SM may be used to treat inflammatory bowel disease (IBD) remains elusive. In the current study, Dextran-Sodium-Sulfate (DSS) induced colitis in mice was used as a model of IBD, and SM was given orally for 7 days. SM administration has significantly reduced the disease activity index (DAI) score and weight lost and colon shortening in the DSS-induced colitis mice. The macrophage infiltration was significantly reduced in the SM treatment group. To explore the mechanisms, macrophage processor cell line Raw 264.7 was used to verify the anti-inflammatory effect of SM. SM treatment inhibited lipopolysaccharide (LPS)-induced macrophage activation in RAW264.7 cells and significantly reduced the production of pro-inflammatory factors. The current study provided evidence that oral administration of SM ameliorates pathological deterioration of IBD in mice, and warrants future clinical application of SM for the management of IBD.
J-Aggregates of Boron Difluoride β-Diketonates in Polymer Matrix: Formation and Dissociation. Temperature-Dependent Luminescence.
Authors: Fedorenrko Elema V. , Mirochnik Anatolii G. 
Published: October 2021

Abstract
Temperature-dependent luminescence of polymer compositions doped with boron difluoride β-diketonates has been investigated. At room temperature, the luminescence of the samples is yellow-green, and it becomes blue when heated. The mechanism of the temperature-dependent luminescence consists in the dissociation of J-aggregates of dyes at heating. The process of dissociation of J-aggregates is reversible. These boron difluoride β-diketonates have the potential in wide-range applications in the field of temperature sensing.Trial registration number Date of registration
Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort
Authors: Soriano Sirena , Curry Kristen , Sadrameli Saeed , Wang Qi , Nute Michael , Reeves Elizabeth , Kabir Rasadul , Wiese Jonathan , Criswell Amber , Schodrof Sarah , Britz Gavin , Gadhia Rajan , Podell Kenneth , Treangen Todd , Villapol Sonia 
Published: October 2021

Abstract
Concussions, both single and repetitive, during contact sports cause brain and body alterations in athletes. The role of the brain-gut connection and changes in the microbiota have not been well established after a head injury or concussion-related health consequences. We recruited 33 Division I Collegiate football players and collected blood, stool, and saliva samples throughout the athletic season. Analysis of the gut microbiome reveals a decrease in abundance for two bacterial species, Eubacterium rectale, and Anaerostipes hadrus, after a diagnosed concussion. No significant differences were found regarding the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during athletic activity. Additionally, S100β and SAA blood levels were positively correlated with the abundance of Eubacterium rectale species among athletes exposed to subconcussive impacts. These novel findings provide evidence that detecting changes in the gut microbiome may pave the way for improved concussion diagnosis following head injury.
Translational Evaluation of a Dodecaborated Albumin Conjugate With Maleimide as a Boron Delivery System for a Neutron Capture Reaction to an F98 Rat Glioma Model
Authors: Kashiwagi Hideki , Kawabata Shinji , Yoshimura Kohei , Fukuo Yusuke , Kanemitsu Takuya , Takeuchi Koji , Hiramatsu Ryo , Nishimura Kai , Kawai Kazuki , Takata Takushi , Tanaka Hiroki , Watanabe Tsubasa , Suzuki Minoru , Miyatake Shin-Ichi , Nakamura Hiroyuki , Wanibuchi Masahiko 
Published: October 2021

Abstract
Boron neutron capture therapy (BNCT) is a biologically targeted, cell-selective particle irradiation therapy that utilizes the nuclear capture reaction of boron and neutron. Recently, accelerator neutron generators have been used in clinical settings, and expectations for developing new boron compounds are growing. In this study, we focused on serum albumin, a well-known drug delivery system, and developed maleimide-functionalized closo-dodecaborate albumin conjugate (MID-AC) as a boron carrying system for BNCT. Our biodistribution experiment involved F98 glioma-bearing rat brain tumor models systemically administered with MID-AC and demonstrated accumulation and long retention of boron. Our BNCT study with MID-AC observed statistically significant prolongation of the survival rate compared to the control groups, with results comparable to BNCT study with boronophenylalanine (BPA) which is the standard use of in clinical settings. Each median survival time was as follows: untreated control group; 24.5 days, neutron-irradiated control group; 24.5 days, neutron irradiation following 2.5 hours after termination of intravenous administration (i.v.) of BPA; 31.5 days, and neutron irradiation following 2.5 or 24 hours after termination of i.v. of MID-AC; 33.5 or 33.0 days, respectively. The biological effectiveness factor of MID-AC for F98 rat glioma was estimated based on these survival times and found to be higher to 12. This tendency was confirmed in BNCT 24 hours after MID-AC administration. MID-AC induces an efficient boron neutron capture reaction because the albumin contained in MID-AC is retained in the tumor and has a considerable potential to become an effective delivery system for BNCT in treating high-grade gliomas.
Modelling of 1D Triangular Ag-Grating for Enhanced Absorption in Thin Film Solar Cell
Authors: Iqbal Tahir , Zainb Zarqa , Tabassum Huma 
Published: October 2021

Abstract
This paper mainly focuses on Design and Optimization of 1-D triangular grating for Solar cell applications using Silver Metal. The weak light trapping in the active layer of thin film solar cells is a major issue in solar cell technology. Periodic grating is one of the methods used to improve light absorption in the thin film solar cell's substrate. The current study presents the effect of a 1-D triangular grating device on solar cell absorption enhancement. The 5.3a COMSOL RF module is used for the desired geometry comprising silicon (c-Si) crystalline as the substrate. The slit width of grating is optimized using near and far-Field Analysis in the designed structure magnifies the light-trapping process in the thin-film solar cell. For this purpose, the transmission spectrums are analyzed at various slit angles angle (142 o −148 o ), constant film thickness (100nm), and constant periodicity (700nm). The optimal value of the slit width is obtained as 350nm, which is half the frequency. Variation of θ= 144.57° yielded the highest value of electric field which corresponds to lowest value of relative transmission in full width at half maxima peak. The transmission spectra were taken by varying film angle (142 o −148 o ) at normal incidence to observe the acceptable value of film thickness for the optimization of the grating system. Such optimization is quite helpful for improvement in the light absorption hence over all efficiency of thin film solar cells.
Partial Relay Selection for Two-Way Mixed RF/FSO DF Networks in the Presence of I/Q Imbalance
Authors: Mittal Shweta , Yadav Pankaj , dwivedi vivek 
Published: October 2021

Abstract
In this paper, the study of mixed radio frequency (RF)/ free space optical (FSO) communication decode and forward (DF) two way relaying (TWR) has been presented. In fact, it has been considered that multiple relays are present out of which the best operational relay is selected as per the partial relay selection (PRS) methodology in the presence of outdated channel state information (CSI). Importantly, the relay nodes are assumed to operate in the presence of in phase (I) quadrature phase (Q) imbalance (IQI). The atmospheric turbulence on the FSO link has been modeled using the Malaga distribution with pointing errors. In addition to this, the impact of type of optical demodulation has been considered in the analysis. For the system model, outage probability expression has been derived in terms of Meijer-G
and Fox’s H-functions. In addition to this, for the TWR system, the outage probability expressions have been modified to present asymptotic results in terms of elementary functions. The numerical analysis of the research work suggests that the overall mixed RF/FSO DF TWR system is impacted by the image rejection ratio (IRR) due to IQI, correlation between outdated CSI, atmospheric turbulence, pointing error and type of optical demodulation in addition to the amount of fading on the RF link.
Exponentially Mean Stability Analysis of Positive Markov Jump Neural Networks with Time Delay
Authors: Yin Kai , Yang Dedong , Liu Jiao , Li Hongchao , Wang Li 
Published: October 2021

Abstract
A new result for the analysis of positive Markov jump neural networks(PMJNNs) with time delay is described in this paper. By rewriting the PMJNNs with time delay in both continues-time and discrete-time domains into equivalent positive neural networks(PNNs) and analyzing their stability issues, two delay-dependent sufficient conditions are presented to ensure that the continuous-time and the discrete-time PMJNNs with time delay are exponentially mean stable(EMS) through using the inequality technique. All conditions obtained in the paper are in terms of standard linear programming, which reduces the conservatism. Finally, two numerical examples are provided to verify the validity of our results.
Whole-Plant Corn Silage Improves Rumen Fermentation and Growth Performance of Beef Cattle by Altering Rumen Microbiota
Authors: Cui Yalei , Liu Hua , Gao Zimin , Xu Junying , Liu Boshuai , Guo Ming , Yang Xu , Niu Jiakuan , Zhu Xiaoyan , Ma Sen , Li Defeng , Sun Yu , Shi Yinghua 
Published: October 2021

Abstract
BackgroundIn recent years, whole-plant corn silage had been widely used in China. Roughage was an important source of nutrition for ruminants and had an important effect on rumen microbiota, which plays an important role in animal growth performance and feed digestion. To better understand the effects of different silages on rumen microbiota, the effects of whole-plant corn silage or corn straw silage on growth performance, rumen fermentation products, and rumen microbiota of Simmental hybrid cattle were studied. Results60 healthy Simmental hybrid cattle were randomly divided into 2 groups with 6 repeats in each group and 5 cattle in each group. They were fed with whole-plant corn silage (WS) diet and corn straw silage (CS) diet respectively. Compared with corn straw silage, whole-plant corn silage significantly increased daily gain and decreased feed-weight ratio of beef cattle. Whole-plant corn silage also decreased the acetic acid in the rumen and the acetate to propionate (A/P) ratio compared with corn straw silage. At the genus level, the relative abundance of Prevotella_1 was significantly increased while the relative abundance of Succinivibrionaceae_UCG-002, Succiniclasticum, norank_f_Bacteroidales_RF16_group, and Ruminococcus_1 was decreased in cattle fed whole-plant corn silage compared with those fed corn straw silage. Prevotella_1 was positively correlated with acetic acid and A/P ratio, Succinivibrionaceae_UCG-002 was positively correlated with propionic acid and butyric acid, and negatively correlated with pH, Succiniclasticum was positively correlated with pH and A/P ratio, and norank_f__F082 and Rikenellaceae_RC9_gut_group were positively correlated with pH, propionic acid and butyric acid. Feeding whole-plant corn silage improved amino acid metabolism, nucleotide metabolism, and metabolism of beef cattle compared with feeding corn straw silage. Correlation analysis between rumen microbiota and metabolic pathways showed that Succinivibrionaceae_UCG-002 was negatively correlated with Carbohydrate Metabolism, Glycan Biosynthesis, and Metabolism, while Prevotellaceae_UCG-003 was positively correlated with Amino Acid Metabolism, and Carbohydrate Metabolism. ConclusionsFeeding whole-plant corn silage can improve the production performance rumen fermentation of beef cattle by altering rumen microbiota, amino acid metabolism, and nucleotide metabolism.
Integrated Proteome and Phosphoproteome Analyses Reveal Early and Late-stage Protein Network of Traumatic Brain Injury
Authors: Huang Yutao , Zhang Haofuzi , Li Xin , Yue Kangyi , Gao Xiangyu , Yang Erwan , Dai Shuhui , Wei Jialiang , Yang Yuefan , Luo Peng , Jiang Xiaofan 
Published: October 2021

Abstract
Traumatic brain injury (TBI) is a major public health concern all around the world. Accumulating evidence suggests that pathological processes after brain injury continuously evolve. Here, we identified the differentially expressed proteins (DEPs) and differentially expressed phosphoproteins (DEPPs) in the early and late stages of TBI in mice using TMT labeling, enrichment of Phos affinity followed, and high-resolution LC-MS/MS analysis. Subsequently, integrative analyses, including functional enrichment-based clustering analysis, motif analysis, cross-talk pathway/process enrichment analysis, and protein-protein interaction enrichment analysis were performed to further identify the different and similar pathophysiologic mechanisms in the early and late stage. Our work reveals a map of early and late-stage protein networks in TBI, which shed light on useful biomarkers and the underlying mechanisms in TBI and its sequelae.
Association of the Geriatric Nutritional Risk Index with the survival of patients with non-small-cell lung cancer after platinum-based chemotherapy
Authors: Karayama Masato , Inoue Yusuke , Yasui Hideki , Hozumi Hironao , Suzuki Yuzo , Furuhashi Kazuki , Fujisawa Tomoyuki , Enomoto Noriyuki , Nakamura Yutaro , Inui Naoki , Suda Takafumi 
Published: October 2021

Abstract
Background
The nutritional status can potentially affect the efficacy of cancer therapy. We evaluated the relationships between the nutritional status and the efficacy of chemotherapy in patients with non-small-cell lung cancer (NSCLC).
Methods
The Geriatric Nutritional Risk Index (GNRI), calculated from body weight and serum albumin, was retrospectively evaluated in 148 patients with NSCLC who received first-line platinum-based chemotherapy and scored as low or high.
Results
Patients with a high GNRI had a significantly higher overall response rate (ORR; 61.8% [95% confidence interval {CI} = 52.5–70.3%] vs. 34.2% [95% CI = 21.2–50.1%, p < 0.004), longer median progression-free survival (PFS; 6.3 months [95% CI = 5.6–7.2 months] vs. 3.8 months [95% CI = 2.5–4.7 months], p < 0.001), and longer median overall survival (OS; 22.8 months [95% CI = 16.7–27.2 months] vs. 8.5 months [95% CI = 5.4–16.0 months], p < 0.001) than those with low GNRI. High GNRI was independently predictive of longer PFS and OS, but not ORR, in multivariate Cox proportional hazard analyses. In 71 patients who received second-line non-platinum chemotherapy, patients with high GNRI exhibited significantly longer PFS and OS than those with low GNRI (both p < 0.001).
Conclusions
GNRI was predictive of prolonged survival in patients with NSCLC who received first-line platinum-based chemotherapy and second-line non-platinum chemotherapy. Assessment of the nutritional status may be useful for predicting the efficacy of chemotherapy.
​Effects of Foliar Application of Nano-Se On Photosynthetic Characteristics and Se Accumulation in Paeonia Ostii
Authors: Wang Hui , Zhang Chunlai , Nie Mei , Cheng Dan , Chen Jianxin , Wang Shengji , Lv Jinhui , Niu Yanbing 
Published: October 2021

Abstract
Background Selenium is an essential micronutrient in human metabolism. However, the Se level in foods is far below the standards due to the fact that it is deficient in two thirds of arable soils. Therefore, consuming Se-enriched plant products which convert inorganic Se into organic Se might be a safe and effective way to supplement Se for the human body. Paeonia ostii is a unique medicinal and edible plant in China, and also a new special woody oil crop. It serves as a perfect mediator for Se biofortification. In this report the effects of nano-Se foliar application on photosynthetic parameters, physiological characteristics and Se-enrichment effect in various plant organs of P. ostii cultivar Feng Dan were investigated in randomized complete block design experiments with different doses of spray in Se-deficient soils.Results By contrast to the control, nano-Se sprays enhanced net photosynthetic rate, transpiration rate, stomatal conductance, intercellular CO2 concentration, and chlorophyll content of Feng Dan. The content of soluble sugar, soluble protein, proline and activities of superoxide dismutase and peroxidase were increased while malondialdehyde content was significantly reduced. The stimulatory effect at concentrations of 6.00 and 8.25 g·hm-2 was the best in this study. nano-Se application significantly increased the Se content in all organs of Fengdan except the root compared to the control, and Se contents in various organs were increased paralleled with the increase of concentrations applied, and ordered as follows under suitable concentration, Testa > leaf > kernel > stem > root.ConclusionsThe above results show that nano-Se sprays at concentrations of 6.00-8.25 g·hm-2 stimulated the growth of Feng Dan and achieved the best Se-enrichment effect in this study. It also proved that the Se biofortification effect depends on its dosage applied and types of plant organs. These results provide guidance on Se enrichment of horticultural crops.
A type IVB secretion system adapted for bacterial killing, biofilm invasion and biocontrol
Authors: Purtschert-Montenegro Gabriela , Cárcamo-Oyarce Gerardo , Pinto-Carbó Marta , Agnoli Kirsty , Bailly Aurelien , Eberl Leo 
Published: October 2021

Abstract
Many bacteria utilize contact-dependent killing machineries to eliminate rivals in their environmental niches. Here, we show that Pseudomonas putida IsoF is able to outcompete a wide range of bacteria with the aid of a novel type IVB secretion system (T4BSS) that can deliver toxic effectors into bacterial competitors. This extends the host range of T4BSSs, which were so far thought to transfer effectors only into eukaryotic cells, to prokaryotes. Bioinformatic and genetic analyses showed that this killing machine is entirely encoded by a rare genomic island, which has been recently acquired by horizontal gene transfer. IsoF utilizes this secretion system not only as a defensive weapon to antagonize bacterial competitors but also as an offensive weapon to invade existing biofilms, allowing the strain to persist in its natural environment. Furthermore, we show that IsoF can protect tomato plants against the plant pathogen Ralstonia solanacearum in a T4BSS-dependent manner, suggesting that IsoF capabilities can be exploited for pest control and sustainable agriculture.
STUB1-SMYD2 Axis Regulated Drug Resistance in Glioma cells
Authors: Pan Kailing , Hu Bin , Wang Lude , Fang Jinyong , Yuan Jianlie , Xu Wenxia 
Published: October 2021

Abstract
Aim: SMYD2 is an important epigenetic regulator that methylates histone and non-histone proteins. This study aims to investigate SMYD2 as an oncogene of gliomas and explore its degradation mechanism induced by cisplatin.Methods: Tumor tissue microarray of 441 glioma patients was collected for SMYD2 immunohistochemistry staining. Kaplan-Meier survival curves were constructed by using he overall survival. mRNA-sequencing analysis was detected for understanding the downstream mechanisms mediated by SMYD2. The half-inhibitory concentrations (IC50) of temozolomide and cisplatin in AZ505-treated and control cells were calculated. Thepotential E3 ubiquitin ligase of SMYD2 was predicted in UbiBrowser and confirmed by knockdown test. The effect of SMYD2 and its E3 ligase on gliomas apoptosis and migration were determined via cell-function assays.Results: High SMYD2 expression correlated with a high WHO stage (P=0.004) and a low survival probability (P=0.012). The inhibition of SMYD2 suppressed the process of EMT by downregulating the expression of COL1A1. AZ505 treatment significantly increased drug sensitivity of glioma cells. And the expression of SMYD2 was markedly reduced by cisplatin treatment via STUB1 mediated degradation. The knockdown of STUB1 could partly reverse the cell function impairment induced by cisplatin.Conclusion: These findings suggested that SMYD2 could be a potential drug target for the treatment of gliomas, and STUB1-mediated degradation of SMYD2 plays an important role in reversing chemotherapy resistance in gliomas.
SELENOT–Knockdown Leads to Reducing the Expression of Key Enzymes of ERAD–System in Cancer Cells Under ER–Stress
Authors: Goltyaev M. V. , Blinova E. V. , Varlamova E. G. 
Published: October 2021

Abstract
SELENOT is one of the seven selenoproteins localized in the ER. The purpose of this work was to study the effect of SELENOT–knockdown on mRNA expression of a large number of genes (ER–stress markers, physiological partners of SELENOT, ER–resident selenoproteins, other selenoproteins) under conditions of ER–stress caused by both selenium–containing compounds (sodium selenite and methylseleninic acid) and non–selenium–containing compounds (dithiothriitol) by the example of two human cancer cell lines A–172 (human glioblastoma) and Caco–2 (human colorectal adenocarcinoma). In the course of this work, it was found that SELENOT–knockdown does not significantly affect viability and proliferative properties, redox homeostasis in A–172 and Caco–2 cells and the acquisition of signs of normal cells by them, does not significantly affect the expression of ER–stress marker genes, ER–resident selenoproteins, with the exception of DIO2 and SELENOM. But it has a significant effect on reducing the levels of mRNA expression of AMFR and RNF5 are important enzymes of the ERAD–system, disrupting its work and leading to the accumulation of proteins with incorrect folding, thereby only aggravating ER stress.
Optimization of Atomized Spray Cutting Fluid Eco-Friendly Turning of Inconel 718 Alloy Using ARAS and CODAS Methods
Authors: Sivalingam Vinothkumar , Poogavanam Ganeshkumar , Natarajan Yuvaraj , Sun Jie 
Published: October 2021

Abstract
Atomized spray cutting fluid (ASCF) is a sophisticated machining technique that achieves higher productivity, enhanced surface quality, extended tool life, and cost benefits. This research aims to analyze the influence of cutting process parameters on Inconel 718 alloy turning in dry and ASCF cutting environments. The critical machining indices such as surface roughness, machining cost, power consumption, and tool life were analyzed concerning these two cooling environments. The cutting parameters were optimized using desirability functional analysis and two types of multicriteria decision making (MCDM) method, such as additive ratio assessment method (ARAS) and combinative distance-based assessment (CODAS) method, were investigated. The composite desirability index (CD) of optimum parameter setting(A2B1C2D2) is improved by 6.34 % compared to the initial parameter setting (A2B1C2D1). The optimum parameters from the MCDM technique are obtained as a cutting speed of 200 m/min, feed rate of 0.08 mm/rev, and depth of cut of 0.2 mm under ASCF environment. ASCF machining significantly minimize the surface roughness, machining cost and power consumption, maximize the tool life by about 16%, 51%, 17% and 48% respectively as compared with dry machining