bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature‐inspired porous multichannel carbon monolith: Molecular cooperative enables sustainable production and high‐performance capacitive energy storage
Authors: Liu Mingquan , Wu Feng , Zheng Lumin , Feng Xin , Li Ying , Li Yu , Bai Ying , Wu Chuan 
Published: July 2021

AbstractThe advancement of supercapacitors (SCs) is closely bound up with the breakthrough of rational design of energy materials. Freestanding and thick carbon (FTC) materials with well‐organized porous structure is promising SC electrode delivering high areal capacitive performance. However, controllable and sustainable fabrication of such FTC electrode is still of great challenges. Inspired by natural honeycombs with cross‐linked multichannel structure, herein, an innovative molecular‐cooperative‐interaction strategy is elaborately provided to realize honeycomb‐like FTC electrodes. The nitrogen‐doped porous carbon monolith (N‐PCM) is obtained with advantages of interconnect pore structure and abundant nitrogen doping. Such strategy is based on naturally abundant molecular precursors, and free of pore‐templates, expensive polymerization catalyst, and dangerous reaction solvent, rendering it a sustainable and cost‐effective process. Systematic control experiments reveal that strong interactions among molecular precursors promise the structural stability of N‐PCM during carbonization, and rational selection of molecular precursors with chemical blowing features is key step for well‐developed honeycomb‐like pore structure. Interestingly, the optimized sample exhibits hierarchical pore structure with specific surface area of 626.4 m2 g−1 and rational N‐doping of 7.01 wt%. The derived SC electrode with high mass loading of 40.1 mg cm−2 shows an excellent areal capacitance of 3621 mF cm−2 at 1 mA cm−2 and good rate performance with 2920 mF cm−2 at 25 mA cm−2. Moreover, the constructed aqueous symmetric SC and quasi‐solid‐state SC produce high energy densities of 0.32 and 0.27 mWh cm−2, respectively. We believe that such a composition/microstructure controllable method can promote the fabrication and development of other thick electrodes for energy storage devices.image
In situ preparation of gel polymer electrolyte for lithium batteries: Progress and perspectives
Authors: Ma Chao , Cui Wenfeng , Liu Xizheng , Ding Yi , Wang Yonggang 
Published: July 2021

AbstractThe practical applications of Li‐ion batteries (LIBs) are challenged by their safety concerns when using liquid electrolytes (LEs). Solid‐state gel polymer electrolytes (GPEs) can address this challenge and have drawn increased attention recently. Normally, GPEs are prepared separately and then assembled into cells, which undoubtedly result in dissatisfactory solid/solid interfacial compatibility and low ionic conductivity. Fortunately, in situ GPEs are proposed to address the above challenges and simplify the preparation process. Typically, LE precursor is injected into the cells and gradually transformed into a quasi‐solid gel state under the conditions of thermal or chemical initiators. Consequently, the obtained in situ GPEs could fully infiltrate the electrode and better interface contact of gel electrolyte/electrode is thus inherited. In this review, the authors focus on the in situ GPEs used in lithium batteries (LBs), and summarize recent progress of the design, synthesis, and applications of in situ GPEs. Based on the different ways of triggering polymerization, there are mainly three methods: thermochemical gelation, polymerization by additional chemical initiators, and cross‐linking initiated by LiO bond. Composite GPEs based on in situ solidification method are introduced as a promising strategy to improve the electrochemical performances. Finally, up‐to‐date research progresses are discussed, and perspectives are provided on the development and challenges of in situ GPEs to meet the requirements for their practical applications in LBs.image
Effects of temperature and food availability on the filtration and excretion rates of Diplodon parallelopipedon (Hyriidae)
Authors: Marroni Soledad , Mazzeo Néstor , Iglesias Carlos 
Published: July 2021

AbstractBivalves can consume detritus, bacteria, phytoplankton, and zooplankton by filtering the water column. Ecological attributes like filtration rate (FR) and excretion rate (ER) are particularly important to better understand the role of bivalves in ecosystem. Here, we aimed to elucidate the FR/ER of Diplodon parallelopipedon in a five‐times replicated laboratory experiment under five levels of temperature (10°C, 15°C, 20°C, 25°C, and 30°C) and three levels of phytoplankton biomass (low, middle, and high). Temperature was the main factor regulating FR and ER in our experimental conditions, as we hypothesized the experimental results showed a nonlinear relationship between FR and water temperature. D. parallelopipedon exerted top‐down control over phytoplankton biomass throughout the temperature gradient tested. Contrarily to our expectation, FR and ER did not vary within the phytoplankton biomass range offered. The experimental evidence suggests D. parallelopipedon might control phytoplankton biomass in different temperature scenarios. Moreover, the excretion of nutrients by D. parallelopipedon, together with a capacity to avoid grazing shown by several phytoplankton species (i.e., buoyance regulation) reveal relevant challenges to our understanding of bivalve‐phytoplankton dynamics, and consequently to the whole ecosystem response, particularly in the presence of more diverse natural phytoplankton communities.
A one covariate at a time, multiple testing approach to variable selection in high‐dimensional linear regression models: A replication in a narrow sense
Authors: Núñez Héctor M. , Otero Jesús 
Published: July 2021

SummaryChudik, Kapetanios, & Pesaran (Econometrica 2018, 86, 1479‐1512) propose a one covariate at a time, multiple testing (OCMT) approach to variable selection in high‐dimensional linear regression models as an alternative approach to penalised regression. We offer a narrow replication of their key OCMT results based on the Stata software instead of the original MATLAB routines. Using the new user‐written Stata commands baing and ocmt, we find results that match closely those reported by these authors in their Monte Carlo simulations. In addition, we replicate exactly their findings in the empirical illustration, which relate to top five variables with highest inclusion frequencies based on the OCMT selection method.
Pharmacological inhibition of IRAK1 attenuates colitis‐induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial–mesenchymal transition
Authors: Feng Zeyu , Duan Zhenglan , Shi Guoping , Wang Qiong , Zhou Jinyong , Chen Yugen 
Published: July 2021

AbstractColorectal cancer (CRC) is the third most common type of cancer. Here, we studied the inhibitory effect of IRAK1 and IRAK4 as a preventive strategy using a colitis‐induced tumorigenesis mouse model. CRC clinical data were obtained from the Gene Expression Omnibus (GEO). An experimental inflammation‐dependent CRC model was induced by treatment with azoxymethane (AOM) and then dextran sodium sulfate (DSS) in C57BL/6 mice. Mice were administered an IRAK1/4 inhibitor by intraperitoneal injection at 3 mg/kg twice each week for 9 weeks. The IRAK1/4 inhibitor attenuated histological changes and prevented tumor growth. Tumor‐associated proteins, including p65 and Ki‐67, were downregulated by the IRAK1/4 inhibitor in AOM/DSS‐treated mice. Additionally, IRAK1/4 inhibitor administration effectively decreased the expression of inflammatory cytokines. Furthermore, we observed that IRAK1/4 inhibitor treatment attenuated colitis‐induced tumorigenesis by inhibiting epithelial–mesenchymal transition. These observations indicate that inhibition of IRAK1 and IRAK4 may suppress experimental colitis‐induced tumorigenesis by inhibiting inflammatory responses and epithelial–mesenchymal transition.
Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats
Authors: Xu Limin , Li Zhigang , Rong Junbo , Lang Lijuan 
Published: July 2021

AbstractThis study aimed to investigate the effect of the neuregulin‐1/epidermal growth factor 4 (NRG1/ErbB4) signaling pathway on visual cortex synaptic plasticity in adult amblyopic rats with monocular deprivation (MD). Compared with the control group, the P wave latency and amplitude of the MD group were prolonged and low, respectively, with reduced synaptic plasticity‐related protein expression, lower number of visual cortex neurons, and increased apoptosis of visual cortex neurons. Recombinant neuregulin‐1 (rNRG1) administration activated the NRG1/ErbB4 signaling pathway and improved the visual cortex synaptic plasticity in MD amblyopic rats. However, the effects of rNRG1 were reversed by AG1478 (ErbB4 receptor blockers). The NRG1/ErbB4 signaling pathway in the parvalbumin neurons from MD rats was also inactivated. Amblyopic rats had significantly low cell activity and downregulated expression of synaptic plasticity‐related proteins. Thus, exogenous administration of NRG1 can activate ErbB4 signal transduction and improve the damaged synaptic plasticity of the visual cortex among amblyopic rats. Further studies are warranted to explore the potential for clinical management of amblyopia.
Therapeutic plasmapheresis for the treatment of thyrotoxicosis: A retrospective multi‐center study
Authors: Builes‐Montaño Carlos E. , Rodriguez‐Arrieta Luis A. , Román‐González Alejandro , Prieto‐Saldarriaga Carolina , Alvarez‐Payares Jose C. , Builes‐Barrera Carlos A. , Arango‐Toro Clara M. 
Published: July 2021

AbstractBackground and aimsThyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and first‐line hyperthyroidism treatment is not always an option. Since the first report in 1970, plasmapheresis is a second‐line treatment for severe or otherwise untreatable thyrotoxicosis when rapid euthyroidism is desired.MethodsWe present a retrospective study of the experience in treating thyrotoxicosis with plasmapheresis between 2012 and 2020 in two specialized centers in Colombia. We register the demographic and clinical characteristic and compare the thyroid hormones and other biochemical measurements before and after treatment.ResultsData from 19 patients was obtained, 58% female with a median age of 35 years (IQR 23.5), and most of them with Graves' disease. The most frequent indication for plasmapheresis was thyroid storm. A median of 4 (IQR 2) sessions lead to a significant reduction in FT4 (P .0001) and TT3 (P < .0003) with a nonsignificant decrease in beta‐blocker (P .7353) dose, no change in hepatic enzymes, and no adverse events. After plasmapheresis, thyroidectomy was performed in 10 patients.ConclusionsPlasmapheresis is an effective and safe treatment option for reducing circulating thyroid hormones in severe thyrotoxicosis when other forms of treatment are contraindicated or in case of urgent thyroid and non‐thyroid surgery. It is limited by its cost and the need for highly specialized resources.
Hsa_circ_0054633 association of C peptide is related to IL‐17 and TNF‐α in patients with diabetes mellitus receiving insulin treatment
Authors: Dai Huixue , Hu Fei , Yang Xiangwei , Hu Peng , Chu Yudong , Bu Shizhong 
Published: July 2021

AbstractBackgroundChronic inflammation damaged the islet and resulted in dysfunction of T2D. Circular RNA is stable and better for biomarker in many diseases. Here, we aimed to identify potential circular RNA hsa_circ_0054633 that can be a biomarkers for the effects of insulin therapy in T2D.MethodsIn this retrospective case‐control study, patients were from Li Huili Hospital, Ningbo, China, from February 10, 2019, to August 15, 2019. We included 47 healthy adults, 46 new‐onset T2D with insulin resistance, and 51 patients with insulin therapy. Serum inflammation factors were tested by ELISA assays. We selected hsa_circ_0054633 as a candidate biomarker and measured its concentration in serum by qRT‐PCR. The Pearson correlation test was used to evaluate the correlation between this circRNA and clinical variables.ResultsClinical data indicated that serum C peptide was increased in T2D treatment with insulin. Serum hsa_circ_0054633 was decreased in insulin treatment group. Hsa_circ_0054633 was negative correlated with C peptide (r = −0.2841, p = 0.0433,). IL‐1 and IL‐6, IL‐17, and TNF‐α were higher in T2D patients and decreased after insulin treatment, only IL‐17 and TNF‐α showed a positive correlation to hsa_circ_0054633 (r = 0.4825, p < 0.0001, and r = 0.6190, p < 0.0001). The area under ROC curve was 0.7432, 0.5839, and 0.7573 for Hsa_circ_0054633, C peptide, and their combination.ConclusionHsa_circ_0054633 level was lower in T2D with insulin treatment than untreated and was a negative correlation with C peptide, and positively correlated with IL‐17 and TNF‐α, suggesting that hsa_circ_0054633 may be a potential early indicator of insulin treatment effect to improve inflammation condition.
Coinfection with severe acute respiratory syndrome coronavirus‐2 and other respiratory viruses at a tertiary hospital in Korea
Authors: Kim Zehwan , Lee Jong Ho 
Published: July 2021

AbstractBackgroundStudies have reported coinfection of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), the cause of coronavirus disease‐2019 (COVID‐19), with other viruses that cause respiratory tract infections (RTIs). We investigated the coinfection rate of SARS‐CoV‐2 and other RTI‐causing viruses, and whether the cycle threshold (Ct) value of a real‐time reverse transcriptase PCR (RT‐PCR) differed when the coinfection occurred during the first wave of COVID‐19 in Daegu, Republic of Korea, in 2020.MethodsAfter performing PCR for SARS‐CoV‐2, we additionally tested for the presence of RTI‐causing viruses to check for coinfection. Subsequently, we identified the specific coexisting respiratory viruses and calculated the coinfection rate. In addition, based on the coinfection status, we compared the Ct values obtained from RT‐PCR for SARS‐CoV‐2 in patients who tested positive for COVID‐19 PCR.ResultsOf 13,717 patients, 123 had positive results on COVID‐19 PCR testing and six tested positive for an RTI‐causing virus. Thus, the coinfection rate was 4.9%. There were no statistically significant differences in the mean Ct values of SARS‐CoV‐2 RT‐PCR between coinfected and non‐coinfected patients.ConclusionThis study computed the coinfection rate of SARS‐CoV‐2 and RTI‐causing viruses and revealed that the mean Ct values in SARS‐CoV‐2 real‐time RT‐PCR did not differ according to the coinfection status.
Age‐ and sex‐specific reference intervals for superoxide dismutase enzyme and several minerals in a healthy adult cohort
Authors: Ghazizadeh Hamideh , Kathryn Bohn Mary , Yaghooti‐Khorasani Mahdiyeh , Kamel Khodabandeh Atieh , Zare‐Feyzabadi Reza , Timar Ameneh , Mohammadi‐Bajgiran Maryam , Oladi Mohammad Reza , Rohban Mohadeseh , Esmaily Habibollah , Ferns Gordon A. , Adeli Khosrow , Ghayour‐Mobarhan Majid 
Published: July 2021

AbstractIntroductionThe aim of this study was to establish RIs for clinically important markers including superoxide dismutase (SOD), serum copper, zinc, calcium, magnesium, and phosphate in a cohort of healthy Iranian adults.MaterialsA subsample from MASHAD cohort study was used to assess serum SOD, copper, zinc, calcium, magnesium and phosphate. Serum SOD was measured according to its inhibitory potential of pyrogallol oxidation. Micro‐ and macro‐minerals were measured using flame atomic absorption spectrometry and a BT3000 autoanalyzer, respectively. Sex‐ and age‐specific RIs were then calculated based on CLSI Ep28‐A3 guidelines.ResultsReference value distributions for studied parameters did not demonstrate any age‐specific differences that were statistically significant. In addition, sex partitioning was not required for all parameters, apart from serum magnesium, which showed a wider range in females (0.81–1.26 mg/dl) compared with males (0.82–1.23 mg/dl).ConclusionThe RIs established in this study can be expected to improve mineral assessment and clinical decision‐making in the Iranian adult population.
Down‐regulated IL36RN expression based on peripheral blood mononuclear cells and plasma of periodontitis patients and its clinical significance
Authors: Zhou Yue , Liang Yufu 
Published: July 2021

AbstractBackgroundThe role of IL‐36 receptor antagonist (IL36RN), a mutated gene expression of IL‐36 in periodontitis patients with peripheral blood mononuclear cells (PBMC) and plasma remains to be undetermined.Materials and methodsOur study discovered the IL36RN expression through GEO public databases and further validated by PBMC and plasma of periodontitis patients and healthy participants. A total of 194 participants of public datasets, consisting of 97 cases of periodontitis and 97 cases of healthy control were retrospectively evaluated and explored the gene enrichment pathways and clinical significance of IL36RN expression accompanied by three different cytokines. Furthermore, the clinical significance of IL36RN was evaluated in mild‐to‐severe patients of periodontitis by the receiver operating curve (ROC) using the area under the curve (AUC).ResultsIL36RN expressions were notably down‐regulated in PBMC and plasma of periodontitis patients. Further, a positive correlation of IL36RN expression was significantly observed between PBMC and plasma of periodontitis patients while IL36RN expression was negatively correlated to serum‐based three different cytokines of periodontitis patients. Meanwhile, the ROC‐AUCs achieved a significantly higher range from 0.80 to 0.87 with PBMC of mild‐to‐severe and moderate‐to‐severe periodontitis patients whereas similar patients with plasma obtained a significant AUC range from 0.73 to 0.83.ConclusionIL36RN can distinctively be detectable in periodontitis patients with PBMC and plasma, which can act as a down‐regulated mutated gene that might play an effective role in causing periodontitis. IL36RN may involve by other inflammatory cytokines in the pathogenesis of periodontitis.
Diagnostic value of red blood cell distribution width, platelet distribution width, and red blood cell distribution width to platelet ratio in children with hemophagocytic lymphohistiocytosis
Authors: Xi Ya , Bai Yongying 
Published: July 2021

AbstractBackgroundTo investigate whether red blood cell distribution width (RDW), platelet distribution width (PDW), and red blood cell distribution width to platelet ratio (RPR) can serve as biomarkers to distinguish hemophagocytic lymphohistiocytosis (HLH) from sepsis in children.MethodsThis is a retrospective study, involving 71 HLH patients, 105 sepsis patients, and 88 normal controls from January 2018 to December 2019. RDW, PDW, and RPR values were obtained from peripheral blood samples before standard treatment. The clinical differential diagnostic values of RDW, PDW, and RPR were analyzed by receiver operating characteristic (ROC) curve. In addition, peripheral blood samples after treatment from HLH patients were also collected for the same analyses.ResultsRDW, PDW, and RPR levels of the HLH patients were significantly higher than those of sepsis and normal controls (p < 0.001). In ROC curve analysis of the RDW, PDW, and RPR for diagnosis of HLH, the area under the curve (AUC) could reach to 0.7799 (95% CI = 0.7113–0.8486), 0.7835 (95% CI = 0.7093–0.8577), and 0.9268 (95% CI = 0.8886–0.9649), respectively. When using the criteria of RDW >13.75, PDW >13.30, and RPR >0.08, the sensitivity was 76.06%, 67.61%, and 84.51%, while the specificity was 68.57%, 85.71%, and 87.62%, respectively. After treatment of HLH patients, PDW and RPR were significantly reduced (p < 0.001).ConclusionsThis study shows that RDW, PDW, and RPR, which can be easily and cheaply detected, are novel indicators for differential diagnosis of HLH. PDW and RPR are useful indices for monitoring the effects of treatment on HLH.
Bridging the science‐practice gap in treatment for posttraumatic stress disorder: Testing strategies to enhance beliefs toward exposure therapy
Authors: Klein Alexandra B. , Kline Alexander C. , Bowling Alexandra R. , Feeny Norah C. 
Published: July 2021

AbstractObjectiveExposure therapies (e.g., prolonged exposure [PE]), are first‐line interventions for posttraumatic stress disorder but remain underutilized, partially due to providers' negative beliefs about these interventions. We examined two experimental strategies aimed at enhancing beliefs towards PE and subsequent utilization.MethodClinicians (N = 155) were randomized to one of three conditions presenting a PE rationale: basic, empirically‐based, or emotionally‐based description. Participants were rerandomized to write or not write arguments for utilizing PE. Before and after PE rationales and 1‐month later, participants completed questions about PE beliefs and utilization.ResultsParticipants reported small yet durable belief change across all rationale conditions, with greatest change following the empirically‐based description. Across conditions, belief change was not impacted by writing condition or associated with utilization.ConclusionAddressing negative beliefs with empirical information may be a brief, cost‐effective strategy to improve clinicians' beliefs toward PE. Complementary strategies that leverage belief modification to increase utilization are needed.
Be under your own influence: Effectiveness of a Culturally‐Adapted drug prevention campaign targeting Reservation‐Dwelling American Indian youth
Authors: Crabtree Meghan A. , Stanley Linda R. , Kelly Kathleen J. , Swaim Randall C. 
Published: July 2021

AbstractBe Under Your Own Influence (BUYOI) is a previously validated school‐based intervention designed to delay adolescent substance use (SU) initiation. This study examined the effectiveness of a culturally‐adapted version of BUYOI in delaying SU initiation among reservation‐dwelling American Indian (AI) youth. Five reservation‐based middle schools participated. Three schools were randomly assigned to receive BUYOI‐AI (N = 321), and two schools served as controls (N = 176). Beginning in 7th grade, all participating students completed four assessments over the study period. Discrete time hazard models estimated the effects of BUYOI on students’ risk of initiating alcohol, alcohol intoxication and marijuana before the end of 8th grade. AI students exposed to BUYOI had a lower risk of initiating alcohol use or intoxication, though sex moderated the effect on intoxication. These findings provide preliminary support for the effectiveness of a culturally‐adapted version of BUYOI in delaying AI youth's first‐time alcohol use and intoxication.