bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on multi-sensor measurement system and evaluation method for roundness and straightness errors of deep-hole parts
Authors: Song Ci , Wang Xibin , Liu zhibing , Chen Hui 
Published: February 2021

Abstract
Precision deep-hole parts are widely used in various fields of industrial production and their machining quality has a great impact on fatigue limit, geometric accuracy, and stability of products. Since roundness and straightness errors are essential technical indexes to evaluate the machining quality of deep-hole parts, accurate measurement and effective evaluation of them are of great significance to ensure the performance of related products. A multi-sensor integrated device that can measure two kinds of shape errors simultaneously was developed based on laser displacement sensor, two-dimensional position-sensitive detector, angle sensor, and laser distance sensor. Aiming at the problem of roundness error evaluation, the solution process of the control points of the minimum zone circle was optimized by calculating the distance between points and searching according to the polygon removal rule. Besides, the rotating projection method was used to evaluate the straightness error effectively. Eventually, the effectiveness of the measuring device and the shape error evaluation method was verified by experimental research.
A Missed Opportunity: Underutilization of Inpatient Behavioral Health Services to Reduce Injection Drug Use Sequelae in Florida
Authors: Coye Austin , Jones Mackenzie T , Bornstein Kasha J. , Tookes Hansel E. , Onge Joan E. St. 
Published: February 2021

Abstract
Background: People who inject drugs (PWID) suffer high morbidity and mortality from injection related infections (IRI). The inpatient setting is an ideal opportunity to treat underlying substance use disorder (SUD), but it is unclear how often this occurs.Objectives: To quantify the utilization of behavioral health services for PWID during inpatient admissions for IRI.Design: Data for all hospital admissions in Florida in FY2017 were obtained from the Agency for Healthcare Administration.Subjects: Hospitalization for IRI were obtained using a validated ICD-10 algorithm and treatment for substance use disorder was quantified using ICD-10-Procedure Coding System (ICD-10-PCS) codes.Main Measure: Behavior health services associated with IRI admissionsKey Results: Among the 20,001 IRI admissions, there were 230 patients who received behavioral health services as defined by ICD-10-PCS SAT codes for treatment for SUD.Conclusions: In a state with a large number of IRI, only a very small portion of admissions received behavioral health services. Increased efforts should be directed to studying referral patterns among physicians and other providers caring for this population and increasing utilization of behavioral health services.
Spatiotemporal variations in groundwater and evaporative demand drive ecophysiological functioning of a phreatophyte in drylands
Authors: Torres-García Maria Trinidad , Salinas-Bonillo Maria Jacoba , Cleverly Jamie R. , Pacheco-Romero Manuel , Cabello Javier 
Published: February 2021

Abstract
Water is the main limiting factor for groundwater-dependent ecosystems (GDEs) in drylands. Predicted climate change (precipitation reductions and temperature increases) and anthropogenic activities such as groundwater drawdown jeopardize the structure and functioning of these ecosystems, presenting new challenges for their management. We developed a trait-based analysis to examine the spatiotemporal variability in the ecophysiology of Ziziphus lotus, a phreatophyte that dominates one of the few terrestrial GDEs of semiarid regions in Europe. We assessed morpho-functional and hydraulic traits along a naturally occurring gradient of depth-to-groundwater (DTGW, 2–25 m) in a coastal aquifer, and throughout the growing season of the species. Increasing DTGW and salinity negatively affected photosynthetic and transpiration rates, increasing plant water stress (lower predawn and midday water potential), and positively affected Huber value (sapwood cross-sectional area per leaf area), reducing leaf area and likely, plant hydraulic demand. However, higher atmospheric evaporative demand fostered higher transpiration rates and water stress. Differences in climatic conditions throughout the growing season drove temporal variability in Z. lotus responses along the DTGW gradient, with warmer and drier conditions promoting carbon assimilation and water loss more intensively at shallow water tables. This multiple-trait analysis allowed us to identify plant ecophysiological thresholds related to the increase in DTGW and evaporative demand during the growing season. These findings highlight the existence of tipping points in the ecophysiological functioning of phreatophytic plants in drylands, which contribute to disentangle the functional responses of the related GDEs under groundwater detriment because of climate change effects.
Clinicopathological and Prognostic Features of Hepatitis B Virus-associated Diffuse Large B-cell Lymphoma: A Single-Center Retrospective Study in China
Authors: Chen Dao-guang , Chen Gang , Wang Chang , Ke Long-feng , Wu Hui , He Hong-ming , Yang Yu , Chen Yanping 
Published: February 2021

Abstract
The main aim of our study was to retrospectively investigate the clinicopathological characteristics and prognosis factors of DLBCL patients with HBV infection in China. We collected 420 patients with DLBCL who were originally diagnosed and treated at Fujian Cancer Hospital, China. In our study, 127 (30.2%) patients were HBsAg-positive. HBsAg-positive DLBCL displayed a younger median onset age (50 vs. 54 years, P=0.002), more frequent involvement of the spleen (19.7% vs. 6.1% , P<0.001), less frequent involvement of the small and large intestine (2.3% vs 11.2%, P=0.003), more advanced disease (stage III/IV: 56.7% vs. 45.1%, P=0.028), and lower expression rate of MYC (49.1% vs. 66.7%, P=0.026). The median follow-up time was 61.9 months. Univariate analysis showed that there was no significant difference in overall survival (OS) between HBsAg-negative and -positive DLBCL (P=0.577). In the HBsAg-positive DLBCL subgroup, age older than 60 years, advanced disease, elevated lactate dehydrogenase (LDH), spleen involvement, B symptoms (fever, night sweats, weight loss), and double expressers of MYC and BCL2 had a significantly worse outcome, and patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) had a better prognosis. Multivariate analysis further confirmed that spleen involvement and rituximab use were independent prognostic factors in HBsAg-positive DLBCL patients. Our study indicates that HBsAg-positive DLBCL has unique clinicopathological features and independent prognostic factors. Moreover, HBV infection does not appear to affect the prognosis of DLBCL patients, and the use of rituximab significantly improves OS in HBsAg-positive DLBCL patients.
Assessment of Surface Water Quality of Mayur River in Khulna City
Authors: Hashan Md. Mahadi , Moniruzzaman S.M. 
Published: February 2021

Abstract
River water quality is one of the foremost concerns now a days as it plays a significant role in human and aquatic life. Mayur River, located on the northwestern side of the Khulna city, is important from numerous points of view like freshwater reservoir, navigation, water source for irrigation, ground for fishing and the main wastewater route of Khulna city. However along with human interruption, the unplanned and untreated crude dumping of domestic, industrial and household waste into it, the natural flow of the river is totally retarded and the river water quality has been degraded on a large scale due to water pollution. This pollution has colossal negative impact on day to day life of the inhabitants living alongside of this river as they use this water for domestic and sometimes drinking purposes. That is where the significance of assessing the water quality of Mayur River has come from. The core objectives of this study is to assess the water quality of Mayur River and to develop a model using statistical analysis between water quality parameters (WQP) and water quality index (WQI) to interpret relationship among them. Water quality was assessed on the basis of WQI calculation using National Sanitary Foundation water quality index method. The temporal WQI value showed that the water quality in Mayur River got worse in dry season than that of wet season due to dilution. Much higher values were obtained in case of biochemical oxygen demand (BOD), turbidity, total solids (TS), chloride, phosphate, nitrate and fecal coliform (FC). Pearson correlation coefficient shows negative relationship among temporal average WQI with other parameters except pH. Regression analysis indicates that 99.7% proportion of variance of dependent variable (temporal average WQI) can be predicted from the independent variables (Dissolved Oxygen (% saturation), BOD, turbidity, TS, pH, temperature change, phosphate, nitrate and FC). Total nine prediction equations were formed using regression coefficients that may be helpful to predict the WQI on the basis of WQP in future.
The Roles of Betulinic Acid on Circulating Concentrations of Creatine Kinase and Immunomodulation in Mice Infected With Chloroquine-Susceptible and Resistant Strains of Plasmodium Berghei
Authors: Olanlokun Oludele John , Okoro Praise Oghenegare , Olorunsogo Olufunso Olabode 
Published: February 2021

Abstract
Complete malarial therapy depends largely on the immunological and inflammatory response of the host to the invading potentials of malarial parasite. In this study, we evaluated the roles of betulinic acid on immunological response, anti-inflammatory potentials and concentrations of creatine kinase in mice infected with chloroquine susceptible (NK 65) and resistant (ANKA) strains of Plasmodium berghei. Serum Interlukins 1β and 6 (IL-1 β, IL-6), tumour necrosis factor alpha (TNFα), immunoglobulins G and M (IgG and IgM), C-reactive protein (CRP) and creatine kinas (CK). Furthermore, liver marker enzymes; aspartate, alanine aminotransferases (AST and ALT, respectively) and gamma glutammyl transferase (GGT) were determined. The results showed that betulinic acid dose dependently decreased IL-1 β, IL-6, TNFα and CRP relative to the infected control. The IgG and IgM levels significantly increased in both models while CK decreased insignificantly in both models. Serum AST, ALT and GGT significantly decreased compared to the infected control. These results showed that betulinic acid has anti-inflammatory, immunomodulatory and mitigating effects on malarial infection in mice. Furthermore, the down-regulatory effect of betulinic acid on CK is indicative of decrease in muscle injury which is a major pathological concern in malarial infection and treatment.
Inhibition of Microglia Over-activation Restores Neuronal Survival in a Mouse Model of CDKL5&nbsp;Deficiency Disorder
Authors: Galvani Giuseppe , Mottolese Nicola , Gennaccaro Laura , Loi Manuela , Medici Giorgio , Tassinari Marianna , Fuchs Claudia , Ciani Elisabetta , Trazzi Stefania 
Published: February 2021

Abstract
BackgroundCDKL5 Deficiency Disorder (CDD), a severe neurodevelopmental disorder characterized by early-onset epilepsy, intellectual disability, and autistic features, is caused by mutations in the CDKL5 gene. Evidence in animal models of CDD showed that absence of CDKL5 negatively affects neuronal survival, as well as neuronal maturation and dendritic outgrowth; however, knowledge of the substrates underlying these alterations is still limited. Neuro-inflammatory processes are known to contribute to neuronal dysfunction and death. Recent evidence shows a subclinical chronic inflammatory status in plasma from CDD patients. However, to date, it is unknown whether a similar inflammatory status is present in the brain of CDD patients and, if so, whether this plays a causative or exacerbating role in the pathophysiology of CDD. MethodsWe evaluated microglia activation using AIF-1 immunofluorescence, proinflammatory cytokine expression and signaling in the brain of a mouse model of CDD, the Cdkl5 KO mouse, which is characterized by an impaired survival of hippocampal neurons that worsens with age. Hippocampal neuron survival was determined by DCX, NeuN and cleaved caspase-3 immunostaining in Cdkl5 KO mice treated with luteolin (10 mg/kg), a natural anti-inflammatory flavonoid. Since hippocampal neurons of Cdkl5 KO mice exhibit increased susceptibility to excitotoxic stress, we evaluated neuronal survival in Cdkl5 KO mice injected with NMDA (60 mg/kg) after a 7-day treatment with luteolin. ResultsWe found increased microglial activation in the brain of the Cdkl5 KO mouse. We found alterations in microglial cell morphology and number, increased levels of AIF-1 and proinflammatory cytokines, and activation of STAT3 signaling. Remarkably, treatment with luteolin recovers microglia alterations as well as neuronal survival and maturation in Cdkl5 KO mice, and prevents the increase in NMDA-induced cell death in the hippocampus. ConclusionsOur results suggest that neuro-inflammatory processes contribute to the pathogenesis of CDD and imply the potential usefulness of luteolin as a treatment option in CDD patients.
NLRP3 Inflammasome Activation Attenuates Neuronal Apoptosis by Upregulating Autophagy through AMPK/Beclin-1 Pathway after Intracerebral Hemorrhage with Ventricular Extension in Rats
Authors: Zhang Zhaoqi , Guo Peiwen , Jia Zhengcai , Chen Tunan , Feng Hua 
Published: February 2021

Abstract
BackgroundIn brain, NLRP3 inflammasome, mainly derived from macrophage/microglia, is involved in proinflammatory and neurodeficits after hemorrhage, and autophagy is vital for neuronal homeostasis and functions. Accumulating evidence suggested that NLRP3 inflammasome and autophagy played an important role in intracerebral hemorrhage (ICH). Thus, this study was designed to further explore the pathogenesis of neurodeficits after in posthemorrhagic hydrocephalus.MethodsAutologous blood injection model was induced to mimic ICH with ventricular extension (ICH-IVH) in Sprague-Dawley rats. To elucidate the underlying mechanism, the NLRP3 inflammasome inhibitor MCC950 was administered abdominally at 1 h after ICH-IVH. Magnetic resonance imaging, neurobehavioral tests, immunofluorescence, western blotting, Fluoro-Jade C- staining, Tunel staining, and Quantitative RNA Sequencing were performed.ResultsIn the acute phase of ICH-IVH, both the expression of NLRP3 inflammasome and the autophagy of neurons were upregulated. The activated NLRP3 in macrophage/microglia promoted the release of IL-1β to extracellular, which contributed to excessive autophagy, leading to neurons apoptosis both in vivo and in vitro. AMPK/Beclin-1 pathway played an important role in NLRP3-related neurons autophagy. Using MCC950(NLRP3 inflammasome specific inhibitor) treatment after ICH-IVH significantly reduced ventricles dilation, improved neurofunction, down-regulated the release of IL-1β, and alleviated neuroinflammation and excessive autophagy.ConclusionsOur finding demonstrated that NLRP3 inflammasome activated in microglia/macrophage aggravated neurological outcomes and neuronal apoptosis by upregulating autophagy after ICH-IVH, which was partly mediated by the AMPK/Beclin-1 pathway. Therefore, inhibiting the activation of NLRP3 may be a potential therapeutic strategy for the neurodeficits of ICH-IVH patients.
The Relationship Between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study
Authors: Tang Molian , Zhou Yiquan , Wang Jialu , Wan Yanping , Xu Renying 
Published: February 2021

Abstract
BackgroundPrevious studies reported that aged population with overweight had a lower mortality after cardiovascular diseases attack, indicating being thinner might not be better. However, the debate is ongoing what is optimal range of body mass index (BMI) for aged population. We aimed to evaluate the association between BMI and incident diabetes mellitus (DM) in Chinese elderly people.Methods6,489 Chinese elderly people (3,828 men and 2,661 women) with medium age of 69 years (interquartile range: 67-74 years) were included in this cohort study. BMI was measured at baseline (2014). All the participants were further classified into eight groups based on baseline BMI with 2.0 kg/m2 interval: ≤17.9 kg/m2, 18.0-19.9 kg/m2, 20.0-21.9 kg/m2, 22.0-23.9 kg/m2, 24.0-25.9 kg/m2, 26.0-27.9 kg/m2, 28.0-29.9 kg/m2, and ≥30.0 kg/m2. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were annually measured during follow-up (2014-2019). DM was confirmed if either FBG ≥7.0 mmol/L or HbA1c ≥6.5%. We used the Cox proportional hazards regression model to evaluate the association between BMI and incident DM.ResultsComparing individuals with a BMI range of 20.0~21.9 kg/m2 (reference), the hazards ratio for incident DM was 2.07 (95% CI: 1.33, 3.22), 2.07 (95% CI: 1.33, 3.23), 2.18 (95% CI: 1.37, 3.47), 2.68 (95% CI: 1.61, 4.46), and 2.26 (95% CI: 1.17, 4.37) for the group with a BMI range of 22.0-23.9 kg/m2, 24.0-25.9 kg/m2, 26.0-27.9 kg/m2, 28.0-29.9 kg/m2, and ≥30.0 kg/m2 after adjusting baseline age, sex, blood pressure, lipid profiles, and eGFR. Each unit increase of BMI (=1.0 kg/m2) was associated with a high risk of 9% (HR=1.09, 95% CI: 1.05, 1.14, P for trend<0.001) after adjusting for above-mentioned confounders.ConclusionsHigh BMI was associated with high risk of developing DM in Chinese aged population. To lower the incidence of DM, it is better to be thinner than heavier.
Effect of Rainfall and pH on Musty Odor Produced in the Sanbe Reservoir
Authors: Kim Sangyeob , Hayashi Shohei , Masuki Shingo , Ayukawa Kazuhiro , Ohtani Shuji , Seike Yasushi 
Published: February 2021

Abstract
Harmful cyanobacterial blooms (HCBs) are continuously formed in water systems such as reservoirs and lakes around the world. In particular, geosmin and 2-methylisoborneol (2-MIB), which are made by cyanobacteria, have caused serious musty-odor problems in the drinking water of the Sanbe reservoir in Japan. To investigate the cause of this musty odor, we conducted field observations for five years (2015–2019). As a result, it was determined that the geosmin was caused by the cyanobacteria as Dolichospermum crassum and Dolichospermum planctonicum, and 2-MIB was caused by the cyanobacteria as Pseudanabaena sp and Aphanizomenon cf. flos-aquae. It was also determined that the occurrence of geosmin and 2-MIB are influenced by changes in water temperature and pH due to the inflow of rainfall. Especially, the geosmin and 2-MIB tended to occur in low rainfall conditions. When there is low rainfall, the reservoir changes to an alkaline state due to the consumption of CO2 by the photosynthesis of phytoplankton. In an alkaline reservoir, CO2 exists in the form of bicarbonate (HCO3-); thus, under these condition cyanobacteria will increase because it uses both CO2 and bicarbonate (HCO3-) for photosynthesis. Our study suggests that for solving the musty-odor problem in the reservoir, it is important to control the reservoir’s pH. Moreover, more focus should be place in managing the water quality problem of the Sanbe Reservoir, especially, during low rainfall years. The results of this study will help in addressing odor related water quality problem in other reservoirs.
Performance of the UCLA Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 Instrument as a Clinical Decision Aid in the Routine Clinical Care of Patients With Systemic Sclerosis
Authors: Zampatti Norina , Garaiman Alexandru , Jordan Suzana , Dobrota Rucsandra Cristina , Becker Mike Oliver , Maurer Britta , Distler Oliver , Mihai Carina 
Published: February 2021

Abstract
Background and objectivesThe University of California Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument 2.0 (UCLA GIT 2.0) is validated to capture gastrointestinal (GI) tract morbidity in patients with systemic sclerosis (SSc). The aims of this study were to determine in a large SSc cohort if the UCLA GIT 2.0 is able to discriminate patients for whom a rheumatologist with experience in SSc would recommend an oesophago-gastro-duodenoscopy (EGD), and if it could identify patients with endoscopically proven oesophagitis or with any pathologic finding on EGD. Methods We selected patients fulfilling the ACR/EULAR 2013 criteria for SSc from our EUSTAR center having completed at least once the UCLA GIT 2.0 questionnaire, and we collected data on gastrointestinal symptoms and EGD from their medical charts. We analysed by general linear mixed effect models several parameters, including UCLA GIT 2.0, considered as potentially associated with the indication of EGD, as well as with endoscopic oesophagitis and any pathologic finding on EGD.Results We identified 346 patients (82.7% female, median age 63 years, median disease duration 10 years, 23% diffuse cutaneous SSc) satisfying the inclusion criteria, who completed UCLA GIT 2.0 questionnaires at 940 visits. EGD was recommended at 169 visits. In multivariable analysis, UCLA GIT 2.0 and some of its subscales (reflux, distention/bloating, social functioning) were associated with the indication of EGD. In 177 EGD performed in 145 patients, neither the total ULCA GIT 2.0 score nor any of its subscales were associated with endoscopic oesophagitis, nor with any pathologic EGD findings.ConclusionsIn a real-life setting, the UCLA GIT 2.0 was able to detect patients with SSc who had an indication for EGD. This supports the utilization of the UCLA GIT 2.0 as a decision aid in routine care for upper GI tract investigation of patients with SSc.