bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporting quality of surgical randomised controlled trials in head and neck cancer: a systematic review
Authors: Canagarajah Netanya Aarabi , Porter George James , Mitra Kurchi , Chu Timothy Shun Man 
Published: February 2021

AbstractPurposeRandomised controlled trials (RCTs) are considered the gold standard for evaluating the efficacy of an intervention. However, previous research has shown that RCTs in several surgical specialities are poorly reported, making it difficult to ascertain if various biases have been appropriately minimised. This systematic review assesses the reporting quality of surgical head and neck cancer RCTs.MethodsA literature search of PubMed and Embase was performed. Papers were included if they reported RCTs which assessed a surgical technique used to treat or diagnose head and neck cancer published during or after 2011. The CONSORT 2010 checklist was used to evaluate the reporting quality of these trials.Results41 papers were included. The mean CONSORT score was 16.5/25 (66% adherence) and the scores ranged from 7.5 (30%) to 25. The most common omissions were full trial protocol (found in 14.6%), participant recruitment method (22%) and effect size with a precision estimate for all outcome measures (29.3%). The full design and implementation of the randomisation methods were reported in 6 (14.6%). Papers published in journals which endorsed CONSORT had significantly higher scores (p = 0.02) and the journal impact factor was significantly correlated with CONSORT score (p = 0.01).ConclusionWe have identified several pieces of information that are underreported in surgical head and neck cancer RCTs. These omissions make understanding and comparing the methodologies and conclusions of RCTs more difficult. The endorsement of CONSORT by journals improved adherence, suggesting that wider adoption of the checklist may improve reporting.
Organ doses of the fetus from external environmental exposures
Authors: Petoussi-Henss Nina , Satoh Daiki , Schlattl Helmut , Zankl Maria , Spielmann Vladimir 
Published: February 2021

AbstractThis article presents nuclide-specific organ dose rate coefficients for environmental external exposures due to soil contamination assumed as a planar source at a depth of 0.5 g cm−2in the soil and submersion to contaminated air, for a pregnant female and its fetus at the 24th week of gestation. Furthermore, air kerma free-in-air coefficient rates are listed. The coefficients relate the organ equivalent dose rates (Sv s−1) to the activity concentration of environmental sources, in Bq m−2or Bq m−3, allowing to time-integrate over a particular exposure period. The environmental radiation fields were simulated with the Monte Carlo radiation transport codes PHITS and YURI. Monoenergetic organ dose rate coefficients were calculated employing the Monte Carlo code EGSnrc simulating the photon transport in the voxel phantom of a pregnant female and fetus. Photons of initial energies of 0.015–10 MeV were considered including bremsstrahlung. By folding the monoenergetic dose coefficients with the nuclide decay data, nuclide-specific organ doses were obtained. The results of this work can be employed for estimating the doses from external exposures to pregnant women and their fetus, until more precise data are available which include coefficients obtained for phantoms at different stages of pregnancy.
Ten years of molecular ballistics—a review and a field guide
Authors: Euteneuer Jan , Courts Cornelius 
Published: February 2021

AbstractMolecular ballistics combines molecular biological, forensic ballistic, and wound ballistic insights and approaches in the description, collection, objective investigation, and contextualization of the complex patterns of biological evidence that are generated by gunshots at biological targets. Setting out in 2010 with two seminal publications proving the principle that DNA from backspatter collected from inside surfaces of firearms can be retreived and successfully be analyzed, molecular ballistics covered a lot of ground until today. In this review, 10 years later, we begin with a comprehensive description and brief history of the field and lay out its intersections with other forensic disciplines like wound ballistics, forensic molecular biology, blood pattern analysis, and crime scene investigation. In an application guide section, we aim to raise consciousness to backspatter traces and the inside surfaces of firearms as sources of forensic evidence. Covering crime scene practical as well as forensic genetic aspects, we introduce operational requirements and lay out possible procedures, including forensic RNA analysis, when searching for, collecting, analyzing, and contextualizing such trace material. We discuss the intricacies and rationales of ballistic model building, employing different tissue, skin, and bone simulants and the advantages of the “triple-contrast” method in molecular ballistics and give advice on how to stage experimental shootings in molecular ballistic research. Finally, we take a look at future applications and prospects of molecular ballistics.
Porcine Aorto-Renal Artery (PARA) model for laparoscopic transcystic common bile duct exploration: the evolution of a training model to meet new clinical needs
Authors: Brewer James O. , Navaratne Lalin , Marchington Stephen W. , Martínez Cecilia David , Quiñones Sampedro Jose , Muñoz Bellvis Luis , Isla Alberto Martínez 
Published: February 2021

Abstract
Background
The transcystic approach to laparoscopic common bile duct exploration has gained popularity for the single-stage management of choledocholithiasis with concomitant gallstones. Our team previously described the use of a porcine aorta segment to simulate the common bile duct during laparoscopic skill training.

Methods
With the advent of the transcystic approach as a contender for the first-line technique of accessing the common bile duct, we present an evolution of the laparoscopic training model using a Porcine Aorta-Renal Artery (PARA) specimen to simulate the structural integrity, dimensions and spatial distribution of both the human cystic and common bile ducts.

Results
This training model allows the use of a choledochoscope for transcystic exploration of the biliary tree. It combines fidelity and reproducibility required for a simulated training model to offer experience in laparoscopic transcystic common bile duct exploration. Validation of the model was demonstrated by 21 surgeons who completed a questionnaire after performing the simulated procedure. In all sections assessing reliability, face validity and content validity of the model, mean rating scores were between 4 and 5 out of five (good or excellent).

Conclusions
We present the evolution of an established training model for laparoscopic common bile duct exploration which focusses the attention on the transcystic approach to the common bile duct and the use of lithotripsy techniques. The need for such a model reflects the shift in the current practice of the laparoendoscopic management of choledocholithiasis with concomitant gallstones from transductal to transcystic approach.
How to improve eyewitness testimony research: theoretical and methodological concerns about experiments on the impact of emotions on memory performance
Authors: Głomb Kaja 
Published: February 2021

AbstractThe purpose of this paper is to present crucial shortcomings of research into eyewitness testimony. It presents the state-of-the-art of research on the relationship between emotions and memory performance. In addition, it addresses contradictions and concerns about previous studies. Despite the declarations of consensus on the role of emotions in memory coding and retrieving, there are as many studies suggesting that emotional events are better remembered than neutral ones, as there are reports that show the opposite. Therefore, by indicating the theoretical and methodological limitations of previous studies, this paper advocates a more rigorous approach to the investigation of emotions and their impact on the quality and quantity of testimony. It also provides a framework for inquiry that allows better comparisons between studies and results, and may help to build a more comprehensive theory of the effects of emotion on memory
Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors
Authors: Hegde Mangala , Joshi Manjunath B. 
Published: February 2021

AbstractSignificant reprogramming of epigenome is widely described during pathogenesis of breast cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is associated with aberrant DNA (de)methylation, which, through promoter and enhancer methylation changes, activates oncogenes and silence tumor suppressor genes in variety of tumors including breast. DNA methylation, one of the major epigenetic mechanisms is catalyzed by evolutionarily conserved isoforms namely, DNMT1, DNMT3A and DNMT3B in humans. Over the years, studies have demonstrated intricate and complex regulation of DNMT isoforms at transcriptional, translational and post-translational levels. The recent findings of allosteric regulation of DNMT isoforms and regulation by other interacting chromatin modifying proteins emphasizes functional integrity and their contribution for the development of breast cancer and progression. DNMT isoforms are regulated by several intrinsic and extrinsic parameters. In the present review, we have extensively performed bioinformatics analysis of expression of DNMT isoforms along with their transcriptional and post-transcriptional regulators such as transcription factors, interacting proteins, hormones, cytokines and dietary elements along with their significance during pathogenesis of breast tumors. Our review manuscript provides a comprehensive understanding of key factors regulating DNMT isoforms in breast tumor pathology and documents unsolved issues.
Locally-synchronous, iterative solver for Fourier-based homogenization
Authors: Glüge R. , Altenbach H. , Eisenträger S. 
Published: February 2021

AbstractWe use the algebraic orthogonality of rotation-free and divergence-free fields in the Fourier space to derive the solution of a class of linear homogenization problems as the solution of a large linear system. The effective constitutive tensor constitutes only a small part of the solution vector. Therefore, we propose to use a synchronous and local iterative method that is capable to efficiently compute only a single component of the solution vector. If the convergence of the iterative solver is ensured, i.e., the system matrix is positive definite and diagonally dominant, it outperforms standard direct and iterative solvers that compute the complete solution. It has been found that for larger phase contrasts in the homogenization problem, the convergence is lost, and one needs to resort to other linear system solvers. Therefore, we discuss the linear system’s properties and the advantages as well as drawbacks of the presented homogenization approach.
HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schönlein purpura nephritis in Finnish pediatric population: a genome-wide association study
Authors: Koskela Mikael , Nihtilä Julia , Ylinen Elisa , Kolho Kaija-Leena , Nuutinen Matti , Ritari Jarmo , Jahnukainen Timo 
Published: February 2021

Abstract
Background
The pathophysiology of Henoch-Schönlein purpura (HSP) is still unclear, but several findings suggest that genetic factors may influence disease susceptibility. We aimed to perform a genome-wide association study (GWAS) in pediatric HSP patients with an emphasis on severe HSP nephritis.

Methods
The study included 46 HSP patients, 42 of whom had undergone kidney biopsy. Forty-nine pediatric patients with an inflammatory bowel disease (IBD) served as an autoimmune disease control group while Finnish bone marrow and blood donors represented the general reference population (n = 18,757). GWAS was performed for HSP and IBD samples in a case-control manner against the reference population. The analysis also included imputation of human leukocyte antigen (HLA) alleles.

Results
GWAS analysis in HSP revealed several polymorphisms from the HLA region that surpassed the genome-wide significance level. Three HLA class II alleles were also significantly more frequent in HSP than in the reference population: DQA1*01:01, DQB1*05:01, and DRB1*01:01. Haplotype DQA1*01:01/DQB1*05:01/DRB1*01:01 occurred in 43.5% of HSP patients, whereas its frequency was 8.2% in IBD patients and 15.0% in the reference population. HSP patients with this haplotype showed similar baseline clinical findings and outcome as HSP patients negative for the haplotype. In IBD patients, no polymorphism or HLA allele appeared significant at the genome-wide level.

Conclusions
Our results suggest that haplotype DQA1*01:01/DQB1*05:01/DRB1*01:01 is associated with susceptibility to HSP, but not with the severity of the kidney involvement. These HLA associations did not occur in IBD patients, suggesting that they are specific to HSP and not related to susceptibility to autoimmune diseases in general.

Graphical abstract
Circulating calcification inhibitors are associated with arterial damage in pediatric patients with primary hypertension
Authors: Skrzypczyk Piotr , Stelmaszczyk-Emmel Anna , Szyszka Michał , Ofiara Anna , Pańczyk-Tomaszewska Małgorzata 
Published: February 2021

Abstract
Background
Circulating calcification inhibitors: fetuin A (FA) and osteoprotegerin (OPG) together with soluble ligand of receptor activator of nuclear factor kappa-B (sRANKL) have been linked to vascular calcifications and arterial damage. This study aimed to evaluate relationships between FA, OPG, sRANKL, and arterial damage in children with primary hypertension (PH).

Methods
In this cross-sectional single-center study, calcification inhibitors (FA, OPG, sRANKL) levels were measured in blood samples of 60 children with PH (median age 15.8, IQR: [14.5–16.8] years) and 20 age-matched healthy volunteers. In each participant, peripheral and central blood pressure evaluation (BP) and ambulatory BP monitoring (ABPM) were performed. Arterial damage was measured using common carotid artery intima media thickness (cIMT), pulse wave velocity (PWV), augmentation index (AIx75HR), and local arterial stiffness (ECHO-tracking—ET) analysis.

Results
Children with PH had significantly higher peripheral and central BP, BP in ABPM, thicker cIMT, higher PWV, and AIx75HR. FA was significantly lower in patients with PH compared to healthy peers without differences in OPG, sRANKL, and OPG/sRANKL and OPG/FA ratios. In children with PH, FA level correlated negatively with cIMT Z-score and ET AIx; sRANKL level correlated negatively with ABPM systolic blood pressure (SBP), SBP load, diastolic BP load, and AIx75HR; OPG/sRANKL ratio correlated positively with SBP load, while OPG/FA ratio correlated positively with ET AIx. In multivariate analysis, FA was a significant determinant of cIMT (mm) and cIMT Z-score.

Conclusions
This study reveals that in children with primary hypertension, arterial damage is related to lower fetuin A concentrations.

Graphical abstract
Fragility curves for non-engineered masonry buildings in developing countries derived from real data based on structural surveys and laboratory tests
Authors: Novelli Viviana Iris , De Risi Raffaele , Ngoma Ignasio , Kafodya Innocent , Kloukinas Panos , Macdonald John , Goda Katsuichiro 
Published: February 2021

AbstractMalawi is located within the southern branch of the active East African Rift System, where earthquakes of moment magnitude (Mw) 7.0 or greater can occur along major faults. The majority of dwellings in the country are non-engineered unreinforced masonry constructions, built by local artisans with little input from engineers. These constructions are highly vulnerable to seismic events due to poor-quality materials and lack of construction detailing. This study presents a new methodology to assess the seismic fragility curves of typical dwellings located in the Central and Southern Malawi. On-site inspections of buildings are carried out to assess geometrical and structural features of 646 façades, and an experimental campaign is performed to characterise the mechanical properties of local construction materials. The collected data allow the identification of different building typologies in terms of quality of materials and construction techniques. The critical failure modes for each of the inspected façade at their ultimate limit state are evaluated analytically. Damage limit states are defined and adopted to derive simplified Static Push-Over (SPO) curves, transformed into incremental dynamic analysis (IDA) curves by using SPO2IDA. The IDA curves are then used to obtain fragility curves for the specific damage limit states. The fragility curves presented herein are the first to be calculated for these building typologies, based on local data, and unfortunately, they show that buildings in Malawi are far more vulnerable to earthquakes than estimated from previously available international reference data. The fragility curves developed in this study may prove useful for assessing the seismic risk of these building typologies in Malawi and other East African countries.
Inflation expectations quantification with fuzzy control system
Authors: Rutkowska Aleksandra , Szyszko Magdalena 
Published: February 2021

AbstractThe inflation expectations of economic agents are one of the most important variables for central banks and monetary policy conduct, but such expectations are not directly observable. Consumers’ expectations are examined in qualitative surveys. The key task is to transform consumers’ survey responses into quantitative proxies of expectations. In this examination, we investigate an alternative method to quantify consumers’ inflation expectations using fuzzy rule-based systems. In order to generate rules in the learning phase, we compare two methods: the Wang-Mendel method based on space partition and the subtractive clustering method. The learning data are information about past inflation and consumers’ opinions as expressed in surveys. The system is built and tested on data from January 2002 to June 2019 for non-euro member states of the EU. The fuzzy rules-based system returns results that outperform a benchmark—the standard quantification procedure—in terms of correlation with a raw approximation of consumer expectations, which is survey balance statistics. The results are robust regarding the benchmark choice. We find the method more promising for economies with lower stability, as it gives more room for the training phase of the algorithm application.
Paleostress reconstruction of faults recorded in the Niedźwiedzia Cave (Sudetes): insights into Alpine intraplate tectonic of NE Bohemian Massif
Authors: Sobczyk Artur , Szczygieł Jacek 
Published: February 2021

AbstractBrittle structures identified within the largest karstic cave of the Sudetes (the Niedźwiedzia Cave) were studied to reconstruct the paleostress driving post-Variscan tectonic activity in the NE Bohemian Massif. Individual fault population datasets, including local strike and dip of fault planes, striations, and Riedel shear, enabled us to discuss the orientation of the principal stresses tensor. The (meso) fault-slip data analysis performed both with Dihedra and an inverse method revealed two possible main opposing compressional regimes: (1) NE–SW compression with the formation of strike-slip (transpressional) faults and (2) WNW–ESE horizontal compression related to fault-block tectonics. The (older) NE-SW compression was most probably associated with the Late Cretaceous–Paleogene pan-regional basin inversion throughout Central Europe, as a reaction to ongoing African-Iberian-European convergence. Second WNW–ESE compression was active as of the Middle Miocene, at the latest, and might represent the Neogene–Quaternary tectonic regime of the NE Bohemian Massif. Exposed fault plane surfaces in a dissolution-collapse marble cave system provided insights into the Meso-Cenozoic tectonic history of the Earth’s uppermost crust in Central Europe, and were also identified as important guiding structures controlling the origin of the Niedźwiedzia Cave and the evolution of subsequent karstic conduits during the Late Cenozoic.
Postural ergonomics and work-related musculoskeletal disorders in neurosurgery: lessons from an international survey
Authors: Mavrovounis Georgios , Meling Torstein R. , Lafuente Jesus , Fountas Konstantinos N. , Demetriades Andreas K. 
Published: February 2021

Abstract
Background
Work-related musculoskeletal disorders (WMSDs) affect a significant percentage of the neurosurgical workforce. The aim of the current questionnaire-based study was to examine the prevalence of WMSDs amongst neurosurgeons, identify risk factors, and study the views of neurosurgeons regarding ergonomics.

Methods
From June to August 2020, members of the “European Association of Neurosurgical Societies,” the “Neurosurgery Research Listserv,” and the “Latin American Federation of Neurosurgical Societies” were asked to complete an electronic questionnaire on the topics of WMSDs and ergonomics.

Results
A total of 409 neurosurgeons responded to the survey, with a 4.7 male to female ratio. Most of the surgeons worked in Europe (76.9%) in academic public hospitals. The vast majority of the participants (87.9%) had experienced WMSDs, mainly affecting the shoulder, neck, and back muscles. The most common operations performed by the participants were “Craniotomy for convexity/intrinsic tumors” (24.1%) and “Open lumbar basic spine” (24.1%). Neurosurgeons agreed that ergonomics is an underexposed area in the neurosurgical field (84.8%) and that more resources should be spend (87.3%) and training curricula changes should be made (78.3%) in order to alleviate the burden of WMSDs on neurosurgeons. Univariate analysis did not reveal any associations between the development of WMSDs and age, gender, tenure, average duration of operation, operating time per week, type of operation, and surgical approach.

Conclusions
The problem of WMSDs ought to be more closely addressed and managed by the neurosurgical community. More studies ought to be designed to investigate specific ergonomic parameters in order to formulate practice recommendations.
Room temperature stable multitalent: highly reactive and versatile copper guanidine complexes in oxygenation reactions
Authors: Paul Melanie , Hoffmann Alexander , Herres-Pawlis Sonja 
Published: February 2021

AbstractInspired by the efficiency of natural enzymes in organic transformation reactions, the development of synthetic catalysts for oxygenation and oxidation reactions under mild conditions still remains challenging. Tyrosinases serve as archetype when it comes to hydroxylation reactions involving molecular oxygen. We herein present new copper(I) guanidine halide complexes, capable of the activation of molecular oxygen at room temperature. The formation of the reactive bis(µ-oxido) dicopper(III) species and the influence of the anion are investigated by UV/Vis spectroscopy, mass spectrometry, and density functional theory. We highlight the catalytic hydroxylation activity towards diverse polycyclic aromatic alcohols under mild reaction conditions. The selective formation of reactive quinones provides a promising tool to design phenazine derivatives for medical applications.Graphic abstract