bluuebunny/crossref_metadata_2025_split huggingface dataset:
Confocal Endomicroscopy Diagnostic Criteria for Early Signet-Ring Cell Carcinoma in Hereditary Diffuse Gastric Cancer
Authors: Pilonis Nastazja D. , O’Donovan Maria , Richardson Susan , Fitzgerald Rebecca C. , Pietro Massimiliano 
Published: December 2021

Abstract
Background
Recognition of early signet-ring cell carcinoma (SRCC) in patients with hereditary diffuse gastric cancer (HDGC) undergoing endoscopic surveillance is challenging. We hypothesized that probe-based confocal laser endomicroscopy (pCLE) might help diagnose early cancerous lesions in the context of HDGC. The aim of this study was to identify pCLE diagnostic criteria for early SRCC.
Methods
Patients with HDGC were prospectively recruited and pCLE assessment was performed on areas suspicious for early SRCC and control regions. Targeted biopsies were taken for gold standard histologic assessment. In Phase I two investigators assessed video sequences off-line to identify pCLE features related to SRCC. In Phase II pCLE diagnostic criteria were evaluated in an independent video set by the investigators blinded to the histologic diagnosis. Sensitivity, specificity, accuracy, and interobserver agreement were calculated.
Results
42 video sequences from 16 HDGC patients were included in Phase I. Four pCLE patterns associated to SRCC histologic features were identified: (A) glands with attenuated margins, (B) glands with spiculated or irregular shape, (C) heterogenous granular stroma with sparse glands, (D) enlarged vessels with tortuous shape. In Phase II, 38 video sequences from 15 patients were assessed. Criteria A and B and C had the highest diagnostic accuracy, with a κ for interobserver agreement ranging from 0.153 to 0.565. A panel comprising these 3 criteria with a cut-off of at least one positive criterion had a sensitivity of 80.9% (95%CI:58.1 - 94.5%) and a specificity of 70.6% (95%CI:44.0 - 89.7%) for a diagnosis of SRCC.
Conclusions
We have generated and validated off-line pCLE criteria for early SRCC. Future real-time validation of these criteria is required.
Dirofilaria Repens Infection of the Eye
Authors: Engelsberg Karl , Bläckberg Jonas 
Published: December 2021

Abstract
We present the first report of a live subconjunctival Dirofilaria Repens in the Nordic countries. A woman had been in India five months before her symptoms started with redness and a foreign sensation in her eye. A worm that moved was found under her conjunctiva (film enclosed). She was instantly operated and the worm was removed (film enclosed). Surgical removal of the worm led to resolution of symptoms and a good clinical outcome.
Subnanometric Cu Clusters on Atomically Fe-doped MoO2 for Furfural Upgrading to Aviation Biofuels
Authors: Zhao Xin , Wang Fengliang , Kong Xiangpeng , Fang Ruiqi , Li Yingwei 
Published: December 2021

Abstract
Single cluster catalysts (SCCs) are considered as versatile boosters in heterogeneous catalysis due to their modifiable single cluster sites and supports. In this work, we report subnanometric Cu clusters dispersed on Fe-doped MoO2 support for biomass-derived furfural upgrading. Systematical characterizations suggest uniform Cu clusters (composing four Cu atoms in average) are homogeneously immobilized on the atomically Fe-doped ultrafine MoO2 nanocrystals (Cu4/Fe0.3Mo0.7O2@C). The atomic doping of Fe into MoO2 leads to significantly modified electronic structure and consequently charge redistribution inside the supported Cu clusters. The as-prepared Cu4/Fe0.3Mo0.7O2@C shows superior catalytic performance in the oxidative coupling of furfural with C3~C10 primary/secondary alcohols to produce C8~C15 aldehydes/ketones (aviation biofuel intermediates), outperforming the conventionally prepared counterparts. DFT calculations and control experiments are further carried out to interpret the structural and compositional merits of Cu4/Fe0.3Mo0.7O2@C in the oxidative coupling reaction, and elucidate the reaction pathway and related intermediates.
Appropriate cesarean rates using Robson’s Ten-Group Classification System in a Brazilian private practice
Authors: Campos Andrea Silveira de Queiroz , Rattner Daphne , Diniz Carmen Simone Grilo 
Published: December 2021

Abstract
Background
The increasing rates of cesarean sections (CS) in places with adequate access to health care are a global concern because they are related to higher rates of maternal and neonatal complications and do not provide a positive childbirth experience for women. The objective is to highlight the possibility of achieving CS rates acceptable by WHO standards, such as Nordic countries, following evidence-based protocols in Brazil.
Methods
A cross-sectional study evaluated CS rates by Robson Groups for women who sought vaginal delivery in a private health practice in Brazil, comparing the rates with Swedish data. A collaborative practice with midwives and obstetricians adopting evidence-based guidelines was offered. The overall CS rate, CS rate by Robson group, contribution of each Robson group to the overall CS rate, clinical and nonclinical interventions and vaginal birth, pre-labour CS and intrapartum CS proportions were estimated. The expected CS rate for the population was calculated by the WHO c-model tool. The analysis used Microsoft EXCEL and the software "R Studio" (version 1.2.1335. 2009-2019).
Results
The overall CS rate was 15.1% (as expected by the WHO c-model tool) in a population composed of 43.7% women in Robson Group 1, 11.4% in Group 2 and 14.9% in Group 5, the greatest responsible for higher rates of CS, who altogether contributed to 75.4% of all cesarean sections.
Conclusions
Multidisciplinary care following evidence-based protocols, associated with a high motivation of both women and professionals of childbirth care for a vaginal route for delivery, may lead to a significant and safe reduction of CS rates, obtaining better results even in contexts such as Brazil, where there is high medicalization of obstetric care and excess of CS.
Evolution of Lysine-Specific Demethylase 1 and REST Corepressor Gene Families and Their Molecular Interaction
Authors: Olivares Montserrat , Merello Gianluca , Verbel Daniel , Gonzalez Marcela , Andrés María , Opazo Juan 
Published: December 2021

Abstract
Lysine-specific demethylase 1A (LSD1) binds to RCOR gene family of corepressors to erase transcriptionally active marks on histones. Functional diversity in these complexes depends on the type of RCOR included, which modulates the complex´s catalytic activity. We studied the duplicative history of RCOR and LSD gene families, and analyzed the evolution of their interaction. We found that RCOR genes are the product of the two rounds of whole-genome duplications that occurred early in vertebrate evolution. In contrast, the origin of the LSD genes traces back before to the divergence of animals and plants. Coimmunoprecipitation experiments using resurrected RCOR and LSD1 proteins of the jawed vertebrate ancestor, and the common hop, date the origin of LSD1-RCOR interaction to the ancestor of animals, fungi, and plants. Overall, we trace LSD1-RCOR complex evolution and propose that animal, fungi, and plant non-model species offer advantages in addressing questions about the molecular biology of this epigenetic complex.
Conceptualization and Psychometric Properties of the Sleep Behavior Self-regulation Dimensions: A Theory-Based Instrument
Authors: ghasemi parvin , Eslami Ahmad Ali , Mazaheri Maryam Amidi 
Published: December 2021

Abstract
Background: Focus on sleep regulation is crucial due to the direct health consequences of insufficient sleep to adolescents’ health and education performance. This study aims to develop and validate an instrument to measure sleep behavior self-regulation (SBSR) and its influential factors in a student sample.Methods: A preliminary version of the measurement instrument was developed using a literature review and conceptual framework. Expert analysis of content validity, item analysis, factor analysis and reliability analysis was performed for the psychometric evaluation. This study has a total of 401 students. The data was analyzed using SPSS 22.0 and AMOS 22.0.Results: The exploratory factor analyses offered a structure with six factors. The model presents a good fit (χ2/df = 1.65, RMSEA = 0.053, CFI = 0.920, and GFI =0.826). General test reliability was good (α = 0.9).Conclusions: SBSRI is a multidimensional instrument and a valid and reliable way of obtaining information about sleep behavior self-regulation. The use of this instrument will make it possible to adjust behavior to subjective goals and real experiences to promote sleep-related behavior change.
Sedimentary, Diagenetic and Accumulation Characteristics of an Offshore Oil-gas Field—a Case Study of Huizhou Depression, Pearl River Mouth Basin, South China Sea
Authors: Liu Longlong , Wu Yinjiao , Dong Hongzhi , Fan Ronghua , Sun Zhongqiang , Huang Rihui , Zhang Jinliang 
Published: December 2021

Abstract
In the Z21 oil-gas field, a total of six depositional lithofacies and two depositional elements were identified based on core observation. Three main diagenetic processes, namely mechanical compaction, cementation, and dissolution of Miocene Zhujiang Formation sandstones were identified according to thin section and scanning electron microscope (SEM) of core samples. Cementations mainly contain silica cementation, carbonate cementation, clay minerals and pyrite. A total of three main pore types, residual primary intergranular pores, secondary dissolution pores and micropores, were identified. Sand sheet deposited in low-energy environment and is characterized by relatively low porosity and permeability values. Lager grain-sized sandstones are of higher quality compared to smaller-sized sandstones. Mechanical compaction, calcite cementation and clay mineral cementation play a key role in reducing porosity and permeability, whereas dissolution of feldspar and debris contribute significantly to improving the reservoir quality. The gas charge occurs prior to oil charge, forming a gas cap in the structural high and an oil ring in the lower formation. Irreducible water stored in the lenticular sandstone of low-porosity and permeability reservoir may convert to movable water as the drill and production perform.
Influence of Covid-19 Vaccination Coverage on Case Fatality Rate
Authors: Raham Tareef Fadhil 
Published: December 2021

Abstract
Background: Recent evidence suggested that an increase in Covid-19 attack rate is correlated to increased case fatality rate (CFR) Covid-19 disease severity. An increase in the attack rate was suggested to lead to an increase in the viral load a proposed mechanism leading to this association. In this context, we conduct this study to look for the influence of decreasing the number of Covid-19 cases through vaccination on CFR.Material and methods: We collected data concerning all countries/territories that implement Covid-19 vaccination at least for the last hundred days ending on 3d of April 2021. They were sixteen in number.Descriptive data analysis used included mean value, standard deviation, and graphical presentation by using Stem-Leaf charts and bar charts.Inferential data analyses used included the One-Sample Kolmogorov-Smirnov (K-S) test and general linear model procedure (GLM).Results: Findings showed that in a highly significant association the mean CFR decreased in countries with > 18 Covid-19 vaccine doses per 100 inhabitants.Conclusion: Vaccination coverage may constitute another factor that determines temporal and spatial variances in CFR.
Design And Synthesis Of Novel Pyrazolopyrimidine-Based Derivatives As Reversible BTK Inhibitors With Potent Antiproliferative Activity In Mantle Cell Lymphoma
Authors: Ran Fansheng , Liu Yang , Zhao Guisen 
Published: December 2021

Abstract
Development of Bruton’s tyrosine kinase (BTK) inhibitors is of great value and significance in the treatment of B-cell malignancies and autoimmune diseases. Herein, a novel class of pyrazolopyrimidine-based BTK inhibitors were designed and evaluated in mantle cell lymphoma (MCL) cell lines. We demonstrated that target compounds had made great progress in improvement of antiproliferative activity compared to lead compound. Compounds 13c, 13g, 13h, 13l, 13n and 13o demonstrated effectively antiproliferative activity in MCL cells lines with single-digit micromolar potency. Furthermore, compound 13l specifically disturbed mitochondrial membrane potential and increased reactive oxygen species level in Z138 cells in a dose-dependent manner. 13l induced cell apoptosis through the caspase 3- mediated apoptotic pathway in Z138 cells. Overall, this study provides valuable lead compounds for developing antitumor agents.
Silver-Chitosan Nanocomposite Prepared With Aqueous Sodium-hydroxide and Aqueous Acetic Acid Solutions: Characteristics and Their Cytotoxic Effects
Authors: Ebrahimi Laya , Hosseinzadeh Saeid , Montaseri Maryam , Berizi Enayat , Yousefi Mohammad Hashem , Jalaei Jaafar , Rahsepar Mansour 
Published: December 2021

Abstract
In this study cytotoxic effects of silver-chitosan nanocomposites with aqueous sodium-hydroxide solution (SCNC-ASHS), and aqueous acetic acid solution (SCNC-AAAS) were evaluated, in vitro. The morphology of the synthesized nanoparticles were characterized by Fourier-Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM). Their cytotoxicity were then evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) in concentrations of 1.56 to 400 µg/ml, and acridine orange/ethidium bromide (AO/EB) staining after 24h and 48h. Results showed the cytotoxicity of 400 µg/ml of SCNC-ASHS on Vero and HT-29 cells of 80.57% and 84.37% after 24h, and 82.20% and 84.84% after 48h. While, the values for SCNC-AAAS on Vero and HT-29 cell-lines were respectively 80.63% and 87.64% after 24h, and 83.60% and 87.44% after 48h. The most toxicity on HT-29 cells was belonged to SCNC-AAAS with IC50 of 40.4 µg/ml. In the staining procedure, cell viability for 25 µg/ml concentration of SCNC-AAAS was 41.84% in HT-29 cell and, for 6.25 µg/ml of SCNC-AAAS was 37.51% in Vero cells. A considerable decrease in cell viability was observed. Types of nanoparticles, synthesis methods, and different cell lines play role in inducing cytotoxicity. Anti-cancer effect of the nanoparticles on the colon cancerous cells (HT-29), of that SCNC-AAAS displayed higher effect than SCNC-ASHS.
Study On The Steel-Aluminum Plastic Clinching of The Inclined Wall Die
Authors: Wang Menghan , Chen Yifeng , Han Yan , Li Lei , Du Menglong 
Published: December 2021

Abstract
Aiming at the problems of low strength and unsatisfactory connection quality of plastic clinching of heterogeneous lightweight materials for the cars body, the Q235 steel sheets, and 5052 aluminum alloy sheets were taken as the research objects, and the inclined wall die for plastic clinching was designed based on the deformation and flow characteristics of sheets in the plastic clinching process. The elastic-plastic finite element numerical simulation and experimental research were used to analyze the plastic clinching process of the inclined wall die, and the failure mode and mechanism of the clinching joints in the shear and peel experiment were deeply studied. The results show that the inclined wall die can effectively increase the interlock value of the joints and reduce the maximum joining force during the clinching process under the condition of ensuring the neck thickness of the joints. When the inclined wall angle α increases from 90° to 100°, the interlock value increases by 38.9%, and the maximum joining force decreases by 8.3%. The influence of inclined wall structure on joint quality can be divided into extrusion stage, radial inflow stage, and stability stage. The comparison between the clinching experiment and the finite element results shows that the two results are in good agreement, which proves that the finite element model of plastic clinching of inclined wall die has a high degree of credibility, and verifies the feasibility of practical application of inclined wall die. Finally, under shear and peel loads, the main failure mode of the joints is separation failure.
Frameless Robot-Assisted Stereotactic Biopsies for Lesions of the Brainstem – A Series of 103 Consecutive Biopsies
Authors: Peciu-Florianu Iulia , Legrand Victor , Monfilliette-Djelad Apolline , Maurage Claude-Alain , Vannod-Michel Quentin , Blond Serge , Touzet Gustavo , Reyns Nicolas 
Published: December 2021

Abstract
PurposeTargeted treatment for brainstem lesions requires above all a precise histopathological and molecular diagnosis. In the current technological era, robot-assisted stereotactic biopsies represent an accurate and safe procedure for tissue diagnosis. We present our center’s experience in frameless robot-assisted biopsies for brainstem lesions. MethodsWe performed a retrospective analysis of all patients benefitting from a frameless robot-guided stereotactic biopsy at our University Hospital, from 2001 to 2017. Patients consented to the use of data and/or images. The NeuroMate® robot (Renishaw™, UK) was used. We report on lesion location, trajectory strategy, histopathological diagnosis and procedure safety. ResultsOur series encompasses 96 patients (103 biopsies) treated during a 17 years period. Mean age at biopsy: 34.0 years (range 1-78). Most common location: pons (62.1%). Transcerebellar approach: 61 procedures (59.2%). Most common diagnoses: diffuse glioma (67.0%), metastases (7.8%) and lymphoma (6.8%). Non conclusive diagnosis: 10 cases (9.7%). After second biopsy this decreased to 4 cases (4.1%). Overall biopsy diagnostic yield: 95.8%. Permanent disability was recorded in 3 patients (2.9%, all adults), while transient complications in 17 patients (17.7%). Four cases of intra-tumoral hematoma were recorded (one case with rapid decline and fatal issue). Adjuvant targeted treatment was performed in 72.9% of patients. Mean follow-up (in the Neurosurgery Department): 2.2 years. ConclusionFrameless robot-assisted stereotactic biopsies can provide the initial platform towards a safe and accurate management for brainstem lesions, offering a high diagnostic yield with low permanent morbidity.
Identification of the Potential Biomarkers in Barrett’S Esophagus Derived Esophageal Adenocarcinoma
Authors: Yi Nan , He Juan , Xie Xike , Liang Liexin , Zuo Guowen , Xiong Mingyue , Liang Yunxiao , Yi Tingzhuang 
Published: December 2021

Abstract
BackgroundClinically, almost 50% of esophageal adenocarcinoma (EAC) originates from the progression of Barrett’s esophagus (BE). EAC is often diagnosed at late stages and is related to dismal prognosis. However, there are still no effective strategies for stratification and therapy in BE derived EAC (BE-EAC).MethodsTwo public datasets (GSE26886 and GSE37200) are analyzed to identify differentially expressed genes (DEGs) between BE and EAC. A series of bioinformatics analyses are performed to explore potential biomarkers associated with BE-EAC.Results27 up- and 104 down-regulated genes are identified between GSE26886 and GSE37200. The GO and KEGG enrichment analysis indicate that the DEGs are highly involved in tumorigenesis. Subsequently, Weighted Gene Co-Expression Network Analysis (WGCNA) is performed to explore the potential genes related to BE-EAC, which are further validated in The Cancer Genome Atlas (TCGA) database. 5 up-regulated genes (MYO1A, ACE2, COL1A1, LGALS4, and ADRA2A) and 3 down-regulated genes (AADAC, RAB27A, and P2RY14) were found in BE-EAC. Among them, the expression level of AADAC, ACE2 and ADRA2A show a significant correlation with patients’ survival probability .Conclusion MYO1A, ACE2, COL1A1, LGALS4, ADRA2A, AADAC, RAB27A, and P2RY14 are potential diagnostic and prognostic biomarkers in BE-EAC.
Optical Sensor Using Space-Domain Active Fiber Cavity Ringdown Technique
Authors: Chen Wenjia , Ou Yiwen , Cheng Chunfu , Zhu Yuanchang , Xiao Wen , Lv Hui 
Published: December 2021

Abstract
A novel active fiber cavity ringdown (FCRD) technique using frequency-shifted interferometry (FSI) is proposed for the first time. Using this scheme, external parameters can be monitored in the space domain by measuring the ringdown distance instead of ringdown time. A bidirectional erbium-doped fiber amplifier (Bi-EDFA) is employed to compensate the inherent cavity loss for achieving higher sensitivity. And two band-pass filters are used to reduce the amplified spontaneous emission (ASE) noise of the Bi-EDFA. Compared with the well-known time-domain active FCRD scheme, our proposed method enables us to avoid using pulsed laser needed in time-domain active FCRD, it uses continuous-wave laser to inject into the fiber cavity and stabilize the optical power in the fiber cavity, which can suppress gain fluctuations of the EDFA and thus improve the detecting precision. Moreover, this novel method enables us to use differential detection method for further reducing the ASE noise, and thus eliminating the baseline drift of ringdown signal. A magnetic field sensor was developed as a proof-of-concept demonstration. The experimental results demonstrate that the proposed sensor with a sensitivity of 0.01537 (1/km·Gs) was achieved. This is the highest magnetic field sensitivity compared to the time-domain active FLRD method. Due to the reduced ASE noise, the stability of the proposed sensing system was also greatly improved.
Influence of Myocardial Bridge On Atherosclerotic Plaque Distribution and Characteristics Evaluated By Near-Infrared Spectroscopy Intravascular Ultrasound
Authors: Saito Kan , Kitahara Hideki , Mastuoka Takaaki , Mori Naoto , Tateishi Kazuya , Fujimoto Yoshihide , Kobayashi Yoshio 
Published: December 2021

Abstract
Purpose

This study aims to clarify whether myocardial bridge (MB) could influence atherosclerotic plaque characteristics assessed by using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) imaging.
Methods

One hundred and sixteen patients who underwent percutaneous coronary intervention (PCI) using NIRS-IVUS imaging were included. MB was defined as an echo-lucent band surrounding left anterior descending artery (LAD). In MB patients, LAD was divided into 3 segments: proximal, MB, and distal segments. In non-MB patients, corresponding 3 segments were defined based on the average length of the above segments. Segmental maximum plaque burden and lipid content derived from NIRS-IVUS imaging in the section of maximum plaque burden were evaluated in each segment. Lipid content of atherosclerotic plaque was evaluated as lipid core burden index (LCBI) and maxLCBI4mm. LCBI is the fraction of pixels indicating lipid within a region multiplied by 1000, and the maximum LCBI in any 4-mm region was defined as maxLCBI4mm.
Results

MB was identified in 42 patients. MB was not associated with maximum plaque burden in proximal segment. LCBI and maxLCBI4mm were significantly lower in patients with MB than those without in proximal segment. Multivariable analysis demonstrated both MB and maximum plaque burden in proximal segment to be independent predictors of LCBI in proximal segment.
Conclusion

Lipid content of atherosclerotic plaque assessed by NIRS-IVUS imaging was significantly smaller in patients with MB than those without. MB could be considered as a predictor of lipid content of atherosclerotic plaque when assessed by NIRS-IVUS imaging.