bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Preventive Effects of Perioperative Oral Care On Surgical Site Infections After Pancreatic Cancer Surgery: A Retrospective Study
Authors: Nobuhara Hiroshi , Matsugu Yasuhiro , Tanaka Junko , Akita Tomoyuki , Ito Keiko 
Published: June 2021

Abstract
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is the most malignant cancer of the gastrointestinal tract, and is associated with high rates of postoperative complications, including surgical site infections (SSIs). Perioperative oral care is an effective measure for preventing postoperative pneumonia. However, the preventive effects of perioperative oral care on SSIs have not been reported. We investigated the preventive effects of perioperative oral care on SSIs after pancreatic cancer surgery.Methods: A total of 103 patients with PDAC who underwent radical resection at Hiroshima Prefectural Hospital (2011–2018) were enrolled in this retrospective study. Of the 103 patients, 75 received perioperative oral care by dentists and dental hygienists (oral care group), whereas 28 did not (control group). Univariate and multivariate analyses with propensity score as a covariate were used to investigate the incidence and risk factors of SSIs in the oral care and control groups. Results: The incidence of SSIs was significantly lower in the oral care group than in the control group (12.0% vs. 39.3%, P = 0.004). Logistic regression analysis revealed that a soft pancreas, the surgical procedure (pancreaticoduodenectomy), blood transfusion, diabetes mellitus, and the absence of oral care intervention were risk factors for SSIs. The odds ratio for oral care intervention was 0.164 (95% confidence interval: 0.047–0.571; P = 0.004). Conclusion: Perioperative oral care reduced the risk of developing SSIs after pancreatic cancer surgery. Our findings indicate that perioperative oral care is a safe and effective infection prevention strategy that should be implemented in future perioperative management.UMIN registration number: UMIN000042082; October 15, 2020, retrospectively registered.
Emotional Regulation In Teens And Improvement of Constructive Skills (EmoTIConS): Study Protocol For A Randomized Controlled Trial
Authors: Pedrini Laura , Rossi Roberta , Magni Laura Rosa , Lanfredi Mariangela , Meloni Serena , Ferrari Clarissa , Macis Ambra , Lopizzo Nicola , Zonca Valentina , Cattaneo Annamaria 
Published: June 2021

Abstract
Background: Emotional dysregulation (ED) constitutes a relevant factor involved in the onset and maintenance of many mental disorders. Targeting ED during adolescence could be determinant both to identify high risk individuals and to promote preventive interventions. This study will aim to evaluate the impact of a brief Dialectical Behavioral Therapy (DBT)-based intervention for adolescent students by measuring changes in emotional regulation skills and impulsive behaviors. Moreover, alterations in biological features related to stress response and inflammation will be assessed as potential biological variables associated to ED.Methods: This is a randomized trial. A total of 20 classes of adolescent students will be recruited among high schools in Brescia, a city in the North of Italy. They will be randomized to the psychoeducational intervention (experimental group) or to a control condition (control group). The intervention will be based on DBT Skills Training for Emotional Problem Solving for Adolescents, and it will consist in four monthly 2-hours sessions (for a total of 8 hours) scheduled during regular school-time. Participants will be assessed at baseline, post-intervention, and at 3 and 6-month of follow-up. The primary outcome measures will be represented by changes in the use of emotional regulation skills (measured by the DBT-Ways of Coping Checklist) and by changes in the frequency of impulsive behaviours (measured by an ad-hoc created checklist). Salivary samples will be collected at baseline and post-intervention to explore possible biological features underlying ED.Discussion: Data from the present project will offer the opportunity to better understand the complex phenomenon of ED. Repeated assessment will cover several domains (emotional, behavioral, social, biological) as potential factors associated with ED. Moreover, it will be possible to measure the effect of the proposed intervention, contributing to improve knowledge on the impact of school-based universal preventive programs. Finally, the current trial will propose an integrated screening- and intervention-based model. Ultimately, this could reduce barriers to youth’s mental health care by fostering collaboration between schools and mental health services. Trial registration: ClinicalTrials.gov ID: NCT04349709. Registration date: 16/04/2020https://clinicaltrials.gov/ct2/show/NCT04349709
Metabolic And Biochemical Changes Associated With Root Growth Restriction Under Cd Stress During Maize Pre-Emergence
Authors: Matayoshi Carolina L. , Pena Liliana B. , Arbona Vicent , Gómez-Cadenas Aurelio , Gallego Susana M. 
Published: June 2021

Abstract
Cadmium (Cd) pollution of agricultural soils is a growing global problem. Plant growth restriction is the main visible symptom of Cd toxicity, and this metal may be particularly harmful to the preformed, seminal root during the pre-emergence stage. In the present study, we focused on Cd phytotoxicity on seminal root growth, nutrient composition, redox status, and hormone homeostasis during the pre-emergence stage, distinguishing between the root apex and the remaining root tissue. After 72 h of metal exposure (50 and 100 µM CdCl2), root length and biomass was diminished, as well as Ca, Fe, Mg, and Mn contents. A redox imbalance was evidenced by changes in peroxidase activities and decreased ascorbate-dehydroascorbate ratio in both root parts. There was less accumulation of carbonylated proteins in both root fractions upon exposition to 50 µM Cd, compared to 100 µM Cd, and this was related to increased 20S proteasome activities. Cd incremented ABA, IAA, and SA contents, but drastically reduced the biologically active gibberellin GA4 and the conjugate jasmonoyl isoleucine (JA-Ile). We demonstrated that the whole root tissue is involved in maize response to Cd stress, which entails redox and hormonal rearrangements, probably directed to widen plant defense lines at the expense of root growth.
Factors associated with single-family home survival in the 2018 Camp Fire, California
Authors: Knapp Eric , Valachovic Yana S , Quarles Stephen L , Johnson Nels G 
Published: June 2021

Abstract
Background

The 2018 Camp Fire, which destroyed 18,804 structures in northern California, including most of the town of Paradise, provided an opportunity to investigate vegetation and housing factors associated with home loss and determine whether California's 2008 adoption of exterior building codes for homes in the wildland-urban-interface (WUI) improved survival. We randomly sampled single-family homes constructed: before 1997, 1997 to 2007, and 2008 to 2018, the latter two time periods being before and after changes to the building code. We then quantified the nearby overstory canopy cover and the distance to the nearest destroyed home and structure from aerial imagery. Using post-fire photographs, we also assessed fire damage and assigned a cause for damaged but not destroyed homes.
Results

Homes built prior to 1997 fared poorly, with only 11.5% surviving, compared with 38.5% survival for homes built in 1997 and after. The difference in survival percentage for homes built immediately before and after the adoption of Chap. 7A in the California Building Code (37% and 44%, respectively), was not statistically significant. Distance to nearest destroyed structure, number of structures destroyed within 100 m, and overstory canopy cover within 100 m of the home were the strongest predictors of survival, but significant interactions with the construction time period suggested that factors contributing to survival differed for homes of different ages. Homes > 18 from a destroyed structure and in areas with overstory canopy cover within 30–100 m of the home of < 53% survived at a substantially higher rate. Most fire damage to surviving homes resulted from radiant heat from nearby burning structures or flame impingement from ignition of near-home combustible materials.
Conclusions

Strong associations between distance to nearest destroyed structure and vegetation within 100 m and home survival in the Camp Fire indicates building and vegetation modifications are possible that would substantially improve outcomes. Among those include improvements to windows and siding in closest proximity to neighboring structures, treatment of wildland fuels, and eliminating near-home combustibles, especially in areas closest to the home (0-1.5 m).
The Lag Effect of Long-Term Exposure to PM2.5 on Esophageal Cancer in Urban-Rural Areas Across China
Authors: li peng , Guo Xiya , Jing Jing , Hu Wenbiao , Wei Wen-Qiang , Qi Xin , Zhuang Guihua 
Published: June 2021

Abstract
Long-term exposure to PM 2.5 pollution is a significant health concern and increases risks for cancers in China. However, the studies regarding the effect of PM 2.5 and esophageal cancer incidence (ECI) among urban-rural areas are limited. In this study, we examined the sex- and area-specific association between long-term exposure to PM 2.5 and ECI, as well as explored the corresponding lag effects on ECI using a geographical weighted Poisson regression. We found that each 10 ug/m 3 PM 2.5 caused ECI risk increases of 1.22% (95% CI: 1.09%, 1.36%) and 1.90% (95% CI: 1.66%, 2.14%) for males and females after covariates controlled, respectively, during the study period. Moreover, the higher 0.17% and 0.64% incidence risks for males and females in rural areas than urban areas, as well as a larger lag period in rural areas, respectively. In addition, higher risks for both sexes appeared in north, northwestern, and east China. The findings indicated that long-term exposure to PM 2.5 was significantly associated with increased risks for ECI, which reinforce a comprehensive understanding for ECI related to PM 2.5.
After Total Knee Arthroplasty Different Knee Position Bring Distinct Effects-a Prospective Study of One Hundred Patients
Authors: zheng ke , Liu Wen-xiang , Zhang Jie-bin 
Published: June 2021

Abstract
Background Following total knee arthroplasty (TKA) blood loss is a major factor influencing functional recovery and quality of life in patients. The aim of this study was to determine the effect of postoperative leg position on blood loss and functional recovery after TKA.Methods One hundred consecutive patients were enrolled in this prospective randomized study, which with degenerative osteoarthritis of the knee. An equal number of patients were randomly allocated to either flexion or extension groups. In the flexion group, the affected leg was elevated 45° at the hip and with 45° of flexion at the knee, while patients in the extension group had the knee extended fully. Primary outcomes were calculated total blood loss (CBL), hidden blood loss(HBL), intraoperative blood loss(IBL),haemoglobin(HB) level and haematocrit(HCT).Results CBL, HBL, postoperative levels of HB and HCT, drop level of HB and HCT between the two groups after 72 hours were significantly different, with patients in the flexion group experiencing lower blood loss than those in the extension group (P < 0.05).However, there no difference between groups in the postoperative levels of HB and HCT, drop level of HB and HCT at 24 hours. Even though after 1 week range of motion (ROM) was statistical difference in groups, but after 6-week rehabilitation, patients from both groups attained a similar ROM in the knee. Conclusions The results of this study definite that after TKA execute the protocol，maintaining a position with the hip 45°flexion and the knee flexed at 45° prolong 48 hours, is an effective method for reducing blood loss and increasing functional ROM.
Clinicopathological Factors Associated with Recurrence in Patients Undergoing Resection of Pancreatic Solid Pseudopapillary Neoplasm
Authors: Paredes Oscar , Kawaguchi Yoshikuni , Luque-Vasquez Carlos , Chavez Ivan , Payet Eduardo , Ruiz Eloy , Celis Juan , Berrospi Francisco , Paredes Kori 
Published: June 2021

Abstract
Background: Solid pseudopapillary neoplasm (SPN) is an uncommon pathology with a low-grade malignancy. Surgery is the milestone treatment. Nevertheless, despite appropriate management, some patients present recurrence. Risk factors associated with recurrence are unclear. The objective of this study was to identify the clinicopathological factors associated with recurrence in patients with the diagnosis of SPN treated with pancreatic resection.Methods: In this retrospective single-center study, medical records of patients treated with pancreatic resection from January 2006 to January 2020 were evaluated. Patients with histological diagnosis of SPN were included. Survival analysis was performed to identify the clinicopathological factors related to recurrence.Results: A total of 589 patients underwent pancreatectomy and, 74(12.6%) were diagnosed with SPN. Seventy patients (94.6%) were female and 4 were male. The median age was 20 years old and, 49(67%) patients were <28 years. The principal symptom was abdominal pain (n=62)(83.8%). The pancreatic head was the most frequent tumor localization (n=32)(43.2%). Distal pancreatectomy was performed in 33(44.6%) patients, followed by pancreaticoduodenectomy (n=32)(43.2%). The median tumor diameter was 7.9cm and, 24(32%) patients presented tumors ≥ 10 cm. Multivisceral resection was performed in 9(12.2%) patients. Four(5.4%) patients presented lymph node metastasis. R0 resection was achieved in all cases. The overall 90-days postoperative morbidity and mortality were 54% and 1.4%, respectively. The pancreatic fistula was the principal postoperative complication(n=27;36.5%). Six(8%) patients presented recurrence after pancreas resection. Liver metastasis was the most frequent recurrence site(n=5). After a median follow-up of 40.2 months, 9(12%) patients died. Five(6.8%) patients died of disease progression. The 1-3-and-5-year OS was 97.1%,90.2% and 79.9%, respectively. The 1-3-and-5-year RFS was 98.4%,89.9% and 87%, respectively. In the univariate Cox regression analysis, age ≥28 years (HR=8.61,95%CI:1.1–73.8), tumor diameter ≥10cm (HR=9.3,95%CI:1.12-79.6), invasion of adjacent organs (HR=7.45,95%CI:1.5–36.9), lymph node metastasis (pN+) (HR=16.8,95%CI:2.96–94.9) and, AJCC(TNM) Stage III (HR=10.1,95%CI:1.2–90.9) were identified as predictors for recurrence. Conclusions: SPN is more frequently diagnosed in young women with a good overall prognosis after an R0 surgical resection even with disease recurrence. Age ≥28 years, larger tumors ≥10cm, invasion of adjacent organs, lymph node metastasis(N+) and, AJCC Stage III were predictors factors of recurrence in resected SPN.
Machine Learning Algorithms for the Identification of Potential Non-Syndromic Intellectual Disability Associated miRNAs
Authors: Betancur Julián González , Guevara-Coto José A , Romero Adarli 
Published: June 2021

Abstract
Background: Intellectual disabilities (IDs) are a group of developmental disorders with high phenotypic and genotypic heterogeneity. Association of genetic elements to IDs has typically been empirically accomplished, however recently, machine learning (ML) has proved to be an excellent instrument to elucidate these associations. miRNAs are short non-coding molecules that participate in spatiotemporal gene regulation, making them relevant for the understanding ID causality. Methods: In this study we used the BrainSpan spatio-temporal expression database to develop a series of machine learning predictors: SVM, RF, FF-ANN, and Stochastic Gradient Descent Classifier. These models were capable of recognizing gene expression profiles. The best classifier was used to label miRNAs associated with NS-IDs using the BrainSpan expression profiles. Results: The model with the best performance was a FF-ANN with 0.78 of F1-score, 0.78 of weighted recall and 0.78 of weighted precision. We used this model to identify miRNAs with high probability to be associated with NS-IDs using the spatio-temporal gene expression profile in the human brain. Labeled miRNAs that were annotated were associated with processes related to either IDs and-or neurodevelopmental processes. Conclusions: The development of a machine learning framework that identified potential NS-ID miRNAs represents an interesting approach for the identification of a potential list of on genes that could be subject for further experimental validation. This study also reinforces the potential of machine learning frameworks in their discovery of potential biomarkers that could improve disease detection and management. Keywords: miRNA association; artificial intelligence; machine learning; intellectual disability; biomarker
Favourable Functional Outcomes In Idiopathic Inflammatory Myositis- A Single Centre Experience Over 15 Years
Authors: Janardana Ramya , N Sangeetha K. , Bhat Vasudha , Balakrishnan Divya , Raj John Michael , Pinto Benzeeta , K Chanakya , Nadig Raghunandan , Mahadevan Anita , Shobha Vineeta 
Published: June 2021

Abstract
Background: To describe the long term clinical outcome and prognostic factors associated with outcome in a longitudinal cohort of idiopathic inflammatory myositis (IIM). Methods: In this retrospective cohort study, IIM patients were classified as per Bohan and Peter criteria. In those with ≥ 24 months of follow-up; treatment response, functional outcomes [health assessment questionnaire-disability index(HAQ-DI) and modified Rankin score(MRS)], Myositis damage index(MDI) at last follow-up was recorded. Results: The cohort consists of 175 patients, with a mean age of 40.9(+12.6) years, M:F 1:3.3; the IIM subsets were dermatomyositis(DM) 78(44.6%), overlap myositis(OM) 45(25.7%), antisynthetase syndrome(ASS) 11(6.3%), polymyositis(PM) 25(14.3%) and juvenile DM/OM in 15(8.6%) patients. Mortality rate was 13.4% and disease related deaths was 9.1%. Ninety-four patients have followed up for >24 months, the median (IQR) of 65(35,100.7) months. At last follow-up, 13.8% were in treatment free remission, 73.4%, 11.7% had complete clinical response and partial clinical response with treatment respectively. HAQ-DI and MRS were favourable in > 90% of patients. At last follow-up, one-third were off-steroids. Discontinuation of steroids was associated with HAQ-DI of 0 and lower MRS. Complete clinical response on/off medication at last follow-up was associated with HAQ-DI of 0[OR10.9; 95%CI(3.3,160)], better MRS[OR 3.2; 95%CI(1.4,7.3)] and lesser MDI[OR 1.7; 95% CI(1.1,2.7)] at the last follow-up as compared to partial response. Baseline parameters and IIM subsets did not significantly influence outcome.Conclusion: Our longitudinal cohort of IIM had a good outcome in all major myositis subsets. Partial clinical response on treatment is associated with worse functional outcomes and damage accrual.
Multi-Objective Optimal Model for Sustainable Management of Groundwater Resources in an Arid and Semi-arid Area Using a Coupled Optimization-Simulation Modeling
Authors: tabari mahmoud mohammad rezapour , Eilbeigi Mehdi , chitsazan Manouchehr 
Published: June 2021

Abstract
Increased abstraction from the aquifer, in addition to the progressive drawdown of groundwater table can increase the concentration of pollutants. This research, optimal scenario for withdrawing water from wells is proposed for the aquifer sustainable development. The aquifer quantitative and qualitative simulation was carried out with the GMS model. The developed code in MATLAB2018b provides the link between the simulation and the NSGA-II optimization tools. Optimal scenario was chosen based on applying the Multiple-Criteria Decision Making (MCDM) and Berda Aggregation Method (BAM). The results show that reducing the current withdrawal rate to 51.55% can establish the quantitative and qualitative stability of the aquifer. The spatial and temporal distribution of nitrate concentration after applying the optimal discharge of wells shows that the nitrate concentration in central and eastern parts of the aquifer have greatly reduced. The developed structure can be used to improve the quantitative and qualitative status of any aquifer.
A Comparative Study of Swine Tissue Composting With Woodchips, Rice Husk And Wheat Straw
Authors: Han Zhenzhen , Ruan Xinyi , Yang Xuchen , Shan Yajing , Chai Jin , Zheng Rong 
Published: June 2021

Abstract
This study evaluated the performance of woodchips (WS), rice husk (RH) and wheat straw (ST) in swine tissue composting. The ST treatment was shown to first reach the highest temperature (55℃) at 12 d of composting and lasted 9 days. The total nitrogen content (TN) was higher and nitrogen loss was lower in ST than in WS or RH treatment. Ammonium nitrogen content(AN) analysis demonstrated lower NH3 emission in ST than in WS or RH treatment. Bacterial community analysis indicated that bacterial diversity was higher in ST than in WS or RH treatment. The most dominant genera in all composting treatments were Pseudomonas, Streptomyces, Brevibacterium, Saccharoporyspora, Acinetobacter, Sphingobacterium, Devosia, Rhizobium, Microbacterium and Sanguibacter. The dominant bacteria were Pseudomonas, Staphylococcus and Sphingobacterium in ST treatment, Streptomyces, Acinetobacter and Sphingopyxis in WS treatment, and Sanguibacter, Pedobacter and Gordonia in RH treatment. Spearman correlation analysis revealed positive relationship of Brevibacterium, Devosia, Sanguibacter, Brachybacterium and Promicromonospora to temperature; Brevibacterium and Staphylococcus to TN; Brevibacterium, Devosia, Microbacterium, Sanguibacter, Brachybacterium and Promicromonospora to AN. This research provides useful information for improving the efficiency of swine tissue composting.