bluuebunny/crossref_metadata_2025_split huggingface dataset:
“We are Performance Philosophy Problems”
Authors: Gibson Janet , Maguire-Rosier Kate , McCaffrey Tony 
Published: December 2024

This article originates from a KeyGroup presentation at the June 2022 Performance Philosophy Problems conference in Helsinki in which the performers of Different Light Theatre Company, a learning-disabled theatre company based in Christchurch, New Zealand, interrogated the conference process, proposing their own research questions for the conference participants as well as questions about theatre, Zoom, and thinking. At the conclusion of the presentation, Laura Cull Ó Maoilearca, asked how ‘we’ (academics and the learning-disabled) can be together in conferences in meaningful and inclusive ways. Two separate pieces form a response to Maoilearca’s question: one from McCaffrey and the other from Maguire-Rosier and Gibson, all participants of the KeyGroup.
McCaffrey starts and ends with videos of performance (and transcription). Firstly the video message sent by Different Light to the Helsinki conference and secondly The Journeyings of Different Light at the ADSA (Australasian Association for Theatre, Drama and Performance Studies) conference at the University of Auckland, New Zealand in December 2022. The performance questions the company's self or ‘voice’ as determined by the negotiation between the learning-disabled artists, the facilitation of a non-disabled director, and the reception of the performance by a (primarily) non-disabled audience. The middle section is an account by McCaffrey as an ‘unreliable director’ of the processes and politics of making learning-disabled theatre. It performatively demonstrates how the voices of the performers are ‘problems’ for theatrical performance, for an academic conference, and for performance philosophy. Maguire-Rosier and Gibson’s easy-read “story” introduces a dance theatre project in Australia (Days Like These) and a socially engaged theatre project in the USA (To Whom I May Concern) to open up scholarship to people usually excluded from academia due to the density of academic language. Although we keep the offerings separate, both advance the idea that learning-disabled theatre and theatres where people show and share disability and diagnoses of dementia disturb some of the key assumptions of theatre and performance studies, notably ‘withness’ and ‘aboutness’. In terms of ‘withusness’, learning disabled theatre provokes a reconsideration of long-held assumptions concerning liveness and co-presence.
Laguna de fracasos
Authors: Lagunaries  
Published: December 2024

EN:
Lagunaries arises as a practice in common from an online virtuality imposed in the context of isolation by the Covid-19 pandemic. Taking possible affections, bodies, knowledge and genealogies as repertoires, we look for altered ways to make the word act [to speak out], breaking the hegemonic device of knowledge transmission, of being together, hacking its binary logic. This group laboratory made up of dancers, performers, educators, researchers, filmmakers and archivists, takes the construction of collective knowledge and the potential of the virtual body as its nodal axis of research.
We perform theories, we investigate modes of escaping the lineal narrativity, using polyphonic and choral forms of thinking / moving / saying / existing. We inhabit the irony of a virtuality that imposes a distance on us and at the same time it hacks all geographical borders. A practice that does not yet have a name, a performance that is always provisional, weaving voices and actions through listening and activating our own and other people’s writings.
We ask ourselves: What is knowing/knowledge? What/where is its archive? How is collective knowledge built? What do we need to know about the other to build a common doing, an affection? What can a collective body do? What can a virtual/digital encounter achieve?

ESP:
Lagunaries surge como práctica común desde una virtualidad impuesta por el contexto de aislamiento por el Covid-19. Tomando como repertorios posibles afectos, cuerpxs, saberes y genealogías, buscamos formas alteradas para hacer acto la palabra, rompiendo el dispositivo hegemónico de transmisión del saber, del estar juntxs, hackeando su lógica binaria. Este laboratorio grupal compuesto por bailarinxs, performers, investigadorxs, cineastes, docentes, archivistas, toma como eje nodal de investigación la construcción del saber y el rol del cuerpo. Performeamos teorías, investigamos modos de fuga de la narratividad lineal, formas polifónicas, corales de pensar/mover/decir/existir. Habitamos la ironía de una virtualidad que nos impone distancia a la vez que hackea las fronteras geográficas. Una práctica que aún no tiene nombre, un hacer performático que siempre es provisorio, y entrama voces y acciones desde la escucha a partir de escritos propios y ajenos. Nos preguntamos ¿Qué es saber? ¿Cuál es su archivo? ¿Cómo se construye saber colectivo? ¿Qué necesitamos saber del otre para construir un hacer común, un afecto? ¿Qué puede un cuerpo colectivo? ¿Qué puede la presencia virtual?
Advances in Alzheimer's Disease Biomarkers
Authors: Li Kuan , Gao Yujie , Liu Muxi , Chen Yizhao 
Published: December 2024

Abstract:
Alzheimer's disease (AD) is a neurodegenerative condition characterized by gradual
onset and complex pathological mechanisms. Clinically, it presents with progressive cognitive decline
and behavioral impairments, making it one of the most common causes of dementia. The intricacies
of its pathogenesis are not fully understood, and current treatment options are limited, with
diagnosis typically occurring at intermediate to advanced stages. The development of new biomarkers
offers a crucial avenue for the early diagnosis of AD and improving patient outcomes.
Several biomarkers with high specificity have been identified. This article reviews biomarkers related
to tau protein, β-amyloid, and blood cells to deepen our understanding of AD and emphasize
the advantages and disadvantages of various biomarkers in order to explore further and mine new
biomarkers for AD diagnosis.
Knowledge Mapping of Stem Cell Therapy for Premature Ovarian Insufficiency: A Bibliometric Analysis (2000-2023)
Authors: Cao Yuting , Huang Jinyuan , Fan Xiaoyin , Dai Yinmei 
Published: December 2024

Background:
Premature Ovarian Failure (POI), a prevalent gynecological, endocrine
disease, significantly impairs the reproductive health of women of childbearing age and presents a
formidable challenge to clinicians. Until now, there has been a lack of effective treatments to fundamentally
improve ovarian function in patients with POI. Stem cell therapy has emerged as a promising
treatment in the field of POI, with notable research progress achieved to date.

Objective:
This review sought to analyze the current status and hotspots of research on stem cell
therapy for POI, forecasting future directions through bibliometrics.

Methods:
Research related to stem cell therapy for POI from 2000 to 2023 was searched in the Web
of Science Core Collection (WOSCC) database by setting subject-term, and the literature was analyzed
econometrically using VOSviewer, CiteSpace, and the R package "bibliometrix."

Results:
According to our search and screening strategy, 203 pieces of literature related to stem cell
therapy for POI were obtained and analyzed. There is a marked annual increase in publications, with
a particularly rapid ascent in recent years. China has become the most prolific country in this field,
with 136 publications. Shanghai Jiao Tong University ranked first among many universities and
institutions in terms of the number of publications and citations. Stem Cell Research & Therapy was
the most popular and influential journal in the field of stem cell therapy for POI. Lai Dongmei has
published the most papers, while Liu Te boasts the highest frequency of co-citations. Investigation
into the mechanisms of exosomes derived from stem cells and their associated signaling pathways is
anticipated to be a crucial research topic in stem cell therapy for POI.

Conclusion:
This review offers the first comprehensive and systematic analysis of the field of stem
cell therapy for POI, with a visual representation of the findings. By summarizing the current status
and projecting forthcoming trends, this study aims to offer guidance and a reference for scholars in
the field.
Intraarticular Injection of Stem Cell and Related Exosome Targeting Synovial Macrophages in Osteoarthritis
Authors: Li Zheng , Huang Yuanchi , Zhang Weisong , Jing Wensen 
Published: December 2024

Abstract:
Osteoarthritis is a costly and debilitating condition, especially as the population ages
and more people are affected. The primary osteoarthritis targets in the joint cavity are chondrocytes
and synovial cells. Researchers are increasingly convinced that macrophages play a crucial
role in the development or therapy of osteoarthritis despite being largely ignored in earlier studies
due to their capacity to switch from a pro-inflammatory to an anti-inflammatory phenotype. Stem
cell or similar extracellular vesicle intraarticular injection offers fresh promise for treating osteoarthritis.
However, the mechanism by which this works needs further investigation. It is important
to investigate the intricate cellular interactions between mesenchymal stem cells (MSCs) and
macrophages. Emerging routes using extracellular vesicles (EVs) are garnering more and more attention
in intercellular communication, which has historically focused on cytokines and soluble
mediators. Therefore, we focus on the polarization of macrophages as a primary consideration in
our study of stem cells and associated EVs utilization in treating knee osteoarthritis.
Immunomodulatory Roles of Mesenchymal Stem Cell-derived Extracellular Vesicles: A Promising Therapeutic Approach for Autoimmune Diseases
Authors: Ahad Mir PRINCE , Hussain Md Sadique , Ahmad Khanday Murtaza , Mohi-ud-din Roohi , Pottoo Faheem Hyder , Hasssan Mir Reyaz 
Published: December 2024

Abstract:
Autoimmune diseases pose a significant challenge due to their complex pathogenesis and
rising prevalence. Traditional therapies are often limited by systemic side effects, immunosuppression,
and lack of long-term efficacy. Mesenchymal stem cells (MSCs) have demonstrated immunomodulatory
properties, primarily through the secretion of extracellular vesicles (EVs), which are now
recognized as potent mediators of immune regulation. MSC-derived EVs carry bioactive molecules
such as microRNAs, proteins, and lipids that influence key immune pathways, making them a promising
therapeutic avenue for autoimmune diseases. This review critically examines the immunomodulatory
mechanisms of MSC-derived EVs, focusing on their role in regulating T cells, B cells,
and macrophages, which are central to autoimmune pathology. We explore recent preclinical and
clinical studies that highlight the ability of MSC-derived EVs to reduce inflammation, promote immune
tolerance, and restore tissue homeostasis in autoimmune settings. Furthermore, we discuss the
advantages of EV-based therapy over MSC-based therapies, including improved safety profiles, lower
immunogenicity, and scalability for clinical application. By evaluating the current landscape of
MSC-derived EV research, we identify key gaps and propose innovative strategies to optimize EVbased
therapies for autoimmune diseases. These strategies include engineering EVs to enhance their
specificity and therapeutic efficacy, as well as integrating them with biomaterials for targeted delivery.
Our review aims to provide a forward-looking perspective on the potential of MSC-derived EVs
as a novel therapeutic approach, moving beyond traditional cell-based therapies to offer more precise
and personalized treatment options for autoimmune diseases.
Acute Effect of Honey-sweetened Coffee on Blood Pressure, Heart Rate and Blood Glucose Level in Healthy Female Subjects
Authors: Aluko Esther Oluwasola , Effiong Etiemem Emmanuel , Olatunbosun Titilope Helen , Bassey Grace Edet 
Published: December 2024

Background:
The consumption of coffee as a beverage and honey as a sweetener is prevalent
worldwide, with each having potential health implications. However, studies on the combined
effect of coffee and honey on blood pressure, heart rate, and blood glucose level are lacking.

Objective:
The objective of this study is to determine whether a three-day consumption of honey-
sweetened coffee will significantly alter the systolic blood pressure (SBP), diastolic blood pressure
(DBP), mean arterial pressure (MAP), heart rate (HR), and fasting blood glucose (BG) levels
in young, healthy female adults.

Methods:
Thirty participants studying at the University of Uyo, aged 18 to 26 years, were randomly
assigned to three groups: control, coffee, and honey-sweetened coffee groups with 10 subjects
each. The control group was given 250 mL of warm water, the coffee group was given 2.25 g of
coffee dissolved in 250 mL of hot water, and the honey-sweetened coffee group was given 2.25 g
of coffee with 20 mL of honey dissolved in 250 mL of hot water for three consecutive days. Before
the start of the experiment, the subjects were asked to rest by sitting comfortably for 15 minutes.
Baseline measurements of blood pressure, heart rate, and blood glucose were taken and recorded
before the consumption of the assigned beverage. Follow-up measurements were taken at
15, 30, 45, and 60 minutes after consumption for blood pressure and heart rate and 30 and 60 minutes
for blood glucose level. This procedure was repeated for three days.

Results:
The results showed no significant changes in systolic blood pressure, diastolic blood pressure,
mean arterial pressure, heart rate, and blood glucose level in the coffee and honey-sweetened
coffee groups compared to the control group.

Conclusion:
The findings of this study revealed that honey-sweetened coffee has no acute effect
on blood pressure, heart rate, and blood glucose level in healthy female individuals. It can, therefore,
be concluded that honey-sweetened coffee has a neutral effect on these physiological parameters,
but a more elaborate study is highly recommended.
A Two-Stage Resilience Enhancement Strategy for Distribution Networks Considering Extreme Weather Conditions
Authors: Miao Luting , Zhang Qian , Zhao Zhenghui 
Published: December 2024

Background:
In the context of increasing extreme weather events and natural disasters,
enhancing the resilience and rapid recovery capabilities of distribution networks has become a critical
focus in power system research.

Objective:
Previous studies primarily focused on the post-disaster power restoration phase of distribution
networks affected by extreme weather without fully addressing the critical role of mobile
energy storage in pre-disaster prevention. To bridge this gap, this paper proposes a two-stage resilience
enhancement strategy for distribution networks, incorporating multi-source coordination
and network reconfiguration.

Methods:
This paper presents a two-stage resilience enhancement strategy for distribution networks
under extreme weather conditions. This strategy combines the coordinated optimization of
various DERs with network reconfiguration. In the pre-disaster stage, optimization is conducted to
manage uncertainties in wind and photovoltaic output. A pre-deployment approach for energy storage
is introduced, incorporating the coordination of the power grid and transportation network to
maximize expected load power recovery and minimize node voltage deviation. In the post-disaster
stage, the strategy integrates distributed resources such as photovoltaic systems, wind power, and
mobile energy storage. It uses a multi-source coordinated dynamic scheduling method to optimize
spatiotemporal energy distribution.

Results:
The results show that this approach significantly improves post-disaster recovery efficiency.
It reduces load shedding and enhances the system's adaptability and disaster resistance.

Conclusion:
The proposed approach enhances the overall resilience and recovery capacity of the
distribution network. This patented technology will be applied in the future.
Investigation of Genetic Variants of Alox12 (rs9904779) Gene in Dental Caries
Authors: Sidhic Nihala , Subbiah Usha 
Published: December 2024

Background:
Dental caries is a biofilm-mediated disease driven by dietary
sugars that reduce pH and promote cariogenic microorganisms. Caries result from a complex
interplay of behaviour, environmental, genetic, and physiological factors, with the
immune response and bacterial activity contributing to enamel demineralization and cavity
formation. Genetic factors, such as SNPs, also influence caries susceptibility, impacting
enamel hardness and inflammatory responses.

Aim:
This study aims to explore the association between the Alox12 gene variant,
rs9904779, and the susceptibility to dental caries.

Methods:
Patients were recruited following ethical approval and informed consent. Saliva
samples were collected and grouped by DMFT index, and genomic DNA was extracted.
PCR analysis focused on Alox12 gene polymorphism with the 223bp product and RFLP.
Statistical analysis was performed using Epi Info software, calculating genotype-risk associations
and a significance threshold of p < 0.05. Chi-square testing assessed genotype
and allele distributions across groups.

Results:
An SNP analysis of Alox12 was conducted to assess the susceptibility of dental
caries. In caries patients, CC genotype was most prevalent (42%), while CG was higher in
controls (52%). Genotype distribution deviated from Hardy-Weinberg equilibrium in caries
(p < 0.05) but not in controls (p > 0.05). The caries group had a higher prevalence of
the C allele, while the CG heterozygote was more frequent in controls (OR = 0.64, p =
0.32).

Conclusion:
This SNP analysis suggests that the Alox12 gene variant rs9904779 may be
a significant predictor for the development of dental caries, highlighting its potential as a
genetic marker for susceptibility to the disease.
Metaforest Algorithm Insights: Predictors of Nocebo Response in ADHD
Authors: Porta Mireia , Barcheni Maggie , Ramírez-saco David , Cunill Ruth , Farré Magí , Saez Marc , López Beatriz , Castells Xavier 
Published: December 2024

Background:
Predicting the nocebo response in randomized controlled trials (RCTs) is
crucial as it can help minimize its influence and improve the evaluation of the side effects of interventions
for ADHD. The aim of this study is to determine the effect of covariates related to study
design, intervention, and patients’ characteristics on the nocebo response in patients with Attention
Deficit Hyperactivity Disorder (ADHD) using Metaforest, and, ultimately, to investigate Metaforest’s
performance in predicting nocebo response in ADHD RCTs.

Methods:
This study is a secondary analysis of a previously published systematic review [1]. Nocebo
response was defined as the proportion of patients experiencing at least one AE while receiving
a placebo. We used Metaforest for investigating patient-, intervention, and study design-related
nocebo response moderators in ADHD RCTs.

Results:
One hundred and five studies were included. Overall, 55.4% of patients experienced at
least one AE while receiving placebo. However, between-study variability on nocebo response was
very high, with nocebo response ranging from 4.2% to 90.2%, leading to high statistical heterogeneity
(I2 = 88.3%). Older patients showed a higher nocebo response. The moderating effects of the
year of publication, treatment length and gender were also significant. The predictive performance
of the model was low-moderate (R2 test = 0, 1922; MSE = 0, 0408).

Conclusion:
Age was the most important nocebo response modifier, followed by year of publication,
treatment length and gender. Metaforest lacked the capability to predict nocebo responses in
future studies.
A Mechanism-Based Comparative Review on Functional Food with Phytomolecules and Marketed Formulation for Type II Diabetes Mellitus
Authors: D. Sureka , Y. Sam Rosan , B. Avinash , N. I. Blessy Victa , Christi V. E. Ida 
Published: December 2024

Abstract:
Type II diabetes mellitus is a chronic disorder characterized by pancreatic beta cell dysfunction,
insulin resistance, and hyperglycemia. Administration of different classes of anti-diabetic
drugs over the long term is essential to maintain normoglycemic levels in affected individuals. This
study is focused on natural analogs as substitutes for the most marketed synthetic and semi-synthetic
anti-diabetic drugs. This study aimed to review phytoconstituents with their mechanism of
action, which are comparatively equivalent to that of the allopathic anti-diabetic marketed drugs,
like biguanides, sulphonylurea, and thiazolidinediones. The methodology used for the review involved
using the keywords collected from online sites, like PubMed, ScienceDirect, and Google
Scholar. At present, different drugs are available for the treatment of diabetes and work with different
mechanisms, like metformin induces the AMPK pathway in hepatocytes and muscle fibers
with increased glucose uptake in peripheral tissues, whereas the phytoconstituents, like quercetin
(flavonoid), mahanimbine, and koenidine (carbazole alkaloids) involve same mechanism as metformin.
Sulfonylureas drugs bind to specific receptors in hepatocytes, resulting in glucose-independent
insulin release. The phytomolecule amyrins (pentacyclic triterpenoid) and kaempferol (flavonoid)
have similar effects as that of sulphonylureas. Thiazoglinediones target adipocytes and
cause GLUT-4 translocation and up-regulation of PPAR and adiponectin gene expression. Phytoconstituents,
like cyanidin-3-glucoside (anthocyanin) and protocatechuic acid (tannin), exhibit a
similar mechanism of action to that of thiazolidinediones. In this review, it can be concluded that
the selected compounds have the same antidiabetic activity as the synthetic drugs. In the future, a
new polyherbal formulation can be developed with these selected molecules having the same mechanisms
of action, with significant therapeutic value without side effects.
Determinants of Consumer Willingness to Pay for Organic Mustard: Evidence from a Consumer Survey in Surabaya
Authors: Sholihah Nadya Ash , Suprehatin  , Muflikh Yanti Nuraeni 
Published: December 2024

Currently, the Indonesian market for organic products is concentrated mainly in big cities such as Jakarta and Surabaya. This is a response to the rising interest of urban consumers in organic products including fresh vegetables. This study aims to examine consumers' willingness to pay (WTP) for organic mustard greens and relevant factors affecting consumers' WTP. The study used primary data from a 150-modern market consumer survey conducted in Surabaya during Mei-June 2023. The data were analyzed using a discrete choice experiment and logit regression model. The results showed that consumers were willing to pay a premium price ranging up to Rp2393.2, Rp3517 and Rp5622.6 per bundle of better-quality of organic mustard greens based on fresh smooth green leaves, branded organic, and lebelled organic attributes, respectively. The results also showed that factors such as age, level of education, and family income significantly influence consumer’s WTP. The findings provide useful information to both policymakers to assist in designing policies for the promotion of organic vegetable production and marketing and organic vegetable business to formulate marketing strategies.