bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Machine Learning–Based Gap-Filling of Fine-Resolution Remotely Sensed Snow Cover Fraction Data by Combining Downscaling and Regression
Authors: Yatheendradas Soni , Kumar Sujay 
Published: October 2021

Abstract
Satellite-based remotely sensed observations of snow cover fraction (SCF) can have data gaps in spatially distributed coverage from sensor and orbital limitations. We mitigate these limitations in the example fine-resolution Moderate Resolution Imaging Spectroradiometer (MODIS) data by gap-filling using auxiliary 1-km datasets that either aid in downscaling from coarser-resolution (5 km) MODIS SCF wherever not fully covered by clouds, or else by themselves via regression wherever fully cloud covered. This study’s prototype predicts a 1-km version of the 500-m MOD10A1 SCF target. Due to noncollocatedness of spatial gaps even across input and auxiliary datasets, we consider a recent gap-agnostic advancement of partial convolution in computer vision for both training and predictive gap-filling. Partial convolution accommodates spatially consistent gaps across the input images, effectively implementing a two-dimensional masking. To overcome reduced usable data from noncollocated spatial gaps across inputs, we innovate a fully generalized three-dimensional masking in this partial convolution. This enables a valid output value at a pixel even if only a single valid input variable and its value exist in the neighborhood covered by the convolutional filter zone centered around that pixel. Thus, our gap-agnostic technique can use significantly more examples for training (∼67%) and prediction (∼100%), instead of only less than 10% for the previous partial convolution. We train an example simple three-layer legacy super-resolution convolutional neural network (SRCNN) to obtain downscaling and regression component performances that are better than baseline values of either climatology or MOD10C1 SCF as relevant. Our generalized partial convolution can enable multiple Earth science applications like downscaling, regression, classification, and segmentation that were hindered by data gaps.
A Single-Column Model Evaluation of Mixing Length Formulations and Constraints for the sa-TKE-EDMF Planetary Boundary Layer Parameterization
Authors: Strobach Edward J. 
Published: October 2021

Abstract
Parameterizing boundary layer turbulence is a critical component of numerical weather prediction and the representation of turbulent mixing of momentum, heat, and other tracers. The components that make up a boundary layer scheme can vary considerably, with each scheme having a combination of processes that are physically represented along with tuning parameters that optimize performance. Isolating a component of a PBL scheme to examine its impact is essential for understanding the evolution of boundary layer profiles and their impact on the mean structure. In this study we conduct three experiments with the scale-aware TKE eddy-diffusivity mass-flux (sa-TKE-EDMF) scheme: 1) releasing the upper limit constraints placed on mixing lengths, 2) incrementally adjusting the tuning coefficient related to wind shear in the modified Bougeault and Lacarrere (BouLac) mixing length formulation, and 3) replacing the current mixing length formulations with those used in the MYNN scheme. A diagnostic approach is adopted to characterize the bulk representation of turbulence within the residual layer and boundary layer in order to understand the importance of different terms in the TKE budget as well as to assess how the balance of terms changes between mixing length formulations. Although our study does not seek to determine the best formulation, it was found that strong imbalances led to considerably different profile structures both in terms of the resolved and subgrid fields. Experiments where this balance was preserved showed a minor impact on the mean structure regardless of the turbulence generated. Overall, it was found that changes to mixing length formulations and/or constraints had stronger impacts during the day while remaining partially insensitive during the evening.
The relevance analysis of GSTP1 rs1695 and lung cancer in the Chinese Han population
Authors: Xiao Jiang , Wang Yulu , Wang Zhimin , Zhang Yao , Li Yutao , Xu Chang , Xiao Man , Wang Haijian , Guo Shicheng , Jin Li , Wang Jiucun , Bao Yang , Shang Yan , Wu Junjie 
Published: October 2021

Background This study explored the relevance between rs1695 and susceptibility to the lung cancer in the Chinese Han population. Stratification analysis was conducted on the basis of age, gender, smoking status, tumor-related family history, and pathological type to observe relations between rs1695 and susceptibility to lung cancer in the subgroups. Methods A case-control study was performed with 974 lung cancer patients who were pathologically diagnosed and 1005 healthy cases based on physical examination to analyze the association between rs1695 and the risk of lung cancer. Results The frequencies of the AA, GA, and GG genotypes of rs1695 were 68.4%, 28.7%, and 2.9% in cases and 64.8%, 30.8%, and 4.2% in controls, respectively. After adjustment for age, gender, smoking status, and family history, it appears that the rs1695 G allele decreases the risk of lung cancer (OR = 0.811, 95% CI 0.684–0.961, P = 0.016). Moreover, compared with the AA genotype, the GA + GG genotype decreased lung cancer susceptibility (OR = 0.808, 95% CI 0.663–0.985, P = 0.035) and the GG genotype (OR = 0.591, 95% CI 0.347–0.988, P = 0.048). In a stratified analysis, the risk of lung cancer in the G allele carriers decreased among the males, patients without a tumor-related family history, and patients with lung adenocarcinoma, especially in smokers. Conclusion The polymorphism of locus rs1695 is related to the risk of lung cancer and is expected to be a target for the prediction of lung cancer.
Teledental Consultations Using a Messaging Application during the COVID-19 Pandemic: Experience from a Singapore COVID-19 Community Care Facility
Authors: Chong Gabriel Tse Feng 
Published: October 2021

Introduction During the ‘Circuit Breaker’ period of the COVID-19 pandemic in Singapore from April to June 2020, governmental policies restricted the practice of dentistry nationwide to the provision of emergency treatment only, regardless of the patient’s COVID status. As such, teledentistry was used as an alternative means to continue providing some form of dental care to COVID-19–positive patients who were admitted to a COVID-19 Community Care Facility. Description The patients were physically triaged by physicians who would send clinical photos to the author via a messaging application, who would in turn triage the patients and assess if they required referral for emergency dental treatment. For patients who did not meet the criteria for referral, the author would advise the physicians on the subsequent management plan which included, but was not limited to, the provision of symptomatic relief. Conclusions This article shows the feasibility of undertaking teledental consultations using clinical photos transmitted via a messaging application. The practical implication is a reduced barrier for patients and healthcare professionals to access teledentistry, without having to resort to sophisticated equipment. Hopefully, this will translate into the continued provision of some form of dental care to patients during the ongoing pandemic as opposed to no care at all.
Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios
Authors: Zhang Dan , Zhang Fan , Liu Meiling , Zhang Mingchao , Zhang Jiong , Wang Jinquan 
Published: October 2021

Introduction Cell-mediated autoimmunity, especially the autoreactivity of T cells, is known to underlie the initiation of anti-glomerular basement membrane disease. However, the T lymphocyte subsets that determine the disease activity, renal fibrosis, and prognosis of anti-GBM disease have not been clearly elucidated. Methods The T lymphocyte subsets (CD4+ and CD8+) were examined on peripheral blood and renal biopsy tissues from 65 patients with biopsy proven anti-GBM disease. Patients were divided into the high ratio group and low ratio group according to the cutoff values in the receiver operating characteristic curve analysis. The correlations of T lymphocyte subsets with clinical, pathological data, and renal outcome were analyzed. Results By the end of follow-up, 45 patients (69.2%) developed end-stage renal disease (ESRD). In peripheral blood, the CD4+/CD8+ ratio showed a predictive ability with a sensitivity and specificity of 91.3% and 52.9%, respectively, which gave rise to a cutoff value of 0.89. There was a significant difference in the activity index between these two groups (3.91 ± 1.38 vs. 2.89 ± 1.13, p = 0.007). In the renal tissues, the CD4+/CD8+ ratio had the optimal cutoff point of 0.82 with a sensitivity of 57.8% and specificity of 85%. The renal activity index was higher for the renal tissues with high CD4+/CD8+ ratios than that of tissues with low CD4+/CD8+ ratios (4.32 ± 1.55 vs. 3.37 ± 1.41, p = 0.016). Peripheral blood CD4+/CD8+ ratios of ≥0.89 or renal tissue CD4+/CD8+ ratios of < 0.82 positively correlated with poor renal prognosis in patients with anti-GBM nephritis. Conclusions The CD4+/CD8+ ratio was associated with renal activity index both in peripheral blood and renal tissue and predicts the renal prognosis of patients with anti-GBM nephritis.
Good in Providing Oral Care, but we Could be Better—Nursing Staff Identification of Improvement Areas in Oral Care
Authors: Andersson Maria , Persenius Mona 
Published: October 2021

Introduction Oral care to older people in short-term care units is a complex and challenging everyday practice for nursing staff. Oral care research and knowledge about prerequisites and obstacles is extensive. However, there is a lack of knowledge about how nursing staff in short-term care units describe their satisfaction about provided oral care in order to maintain older people's oral health. Objective The purpose of this study was to describe how nursing staff perceive their satisfaction of oral care provided for older people in short-term care units and to identify oral care improvements. Methods This study reports on the results of two open-ended questions that were part of a larger study. Informants ( n = 54) were nursing staff working in the involved short-term care units in municipalities from both densely and sparsely populated regions in central and northern Sweden. The answers to the open-ended questions were analyzed using content analysis. Results The analysis yielded one main category; “ Working together to improve satisfaction with older people's oral care” and four subcategories: “ Older people's oral health,” “ Consideration and respect for the older person's autonomy,” “ Having access to adequate products,” and “ Working together in the same direction.” Conclusion Identification of older people's oral health problems together with adequate nursing intervention will increase older people's health outcomes and quality of life. However, regardless of work role, the nursing staff might have difficulty changing their behavior or transforming intentions into actions. Oral care is a complicated and proactive practice that requires nursing staff's attention as well as both educational and organizational initiatives. Working in a supportive and collaborative relationship provides prerequisites for optimal oral care in short-term care units.
Racial and Gender Shoulder Arthroplasty Utilization Disparities of High- and Low-Volume Centers in New York State
Authors: Markes Alexander R. , Pareek Ayoosh , Mesfin Addisu , Benjamin Ma C. , Ward Derek 
Published: October 2021

Introduction The literature has consistently demonstrated utilization disparities in joint replacement procedures, though no studies have evaluated disparities in total shoulder arthroplasty with regard to operative volume. Methods We queried the New York (NY) Statewide Planning and Research Cooperative System (SPARCS) database for 32 410 total shoulder arthroplasties performed between 2009 and 2017. Patients were identified using Clinical Classifications Software code 154 for Non-Hip/Knee Arthroplasty and All Patient Refined-Diagnosis Related Group code 322 for Shoulder. Racial groups included Hispanic, non-Hispanic white, non-Hispanic black, and Other. High-volume centers were facilities that performed 2 standard deviations above the mean annual procedures. Utilization rates were calculated by dividing total shoulder arthroplasties per group by the 2010 NY Census population of that group. The Fisher exact test was used to determine significance. Results Total shoulder arthroplasty utilization increased from 43/100 000 to 73/100 000, two-thirds of which was driven by an increase in white resident utilization. More White residents per 100 000 underwent shoulder arthroplasty than Black, Hispanic, and Other residents per 100 000 residents of their respective race. White residents were 90% more likely than Hispanic residents to undergo total shoulder arthroplasty at high-volume centers ( P = .04). There were no differences in utilization rate regarding operative volume comparing Black or Other residents to White residents. More females underwent total shoulder arthroplasty than males, though there was no difference in utilization rate regarding operative volume. Conclusion Though total shoulder arthroplasty utilization nearly doubled, disparities persisted across gender and minority groups particularly in Hispanic utilization as White residents were 90% more likely than Hispanic residents to undergo shoulder arthroplasty at high-volume centers.
Indirect comparison of tisagenlecleucel and blinatumomab in pediatric relapsed/refractory acute lymphoblastic leukemia
Authors: Verneris Michael R. , Ma Qiufei , Zhang Jie , Keating Amy , Tiwari Ranjan , Li Junlong , Yang Hongbo , Agarwal Abhijit , Pacaud Lida 
Published: October 2021

Abstract
In the absence of head-to-head trials, an indirect-treatment comparison can estimate the treatment effect of tisagenlecleucel in comparison with blinatumomab on rates of complete remission (CR) and overall survival (OS) in patients with relapsed or primary refractory (R/R) acute lymphoblastic leukemia (ALL). Patient-level data from two pivotal trials, ELIANA (tisagenlecleucel; n = 79) and MT103-205 (blinatumomab; n = 70), were used in comparisons of CR and OS, controlling for cross-trial difference in available patient characteristics. Five different adjustment approaches were implemented: stabilized inverse probability of treatment weight (sIPTW); trimmed sIPTW; stratification by propensity score quintiles; adjustment for prognostic factors; and adjustment for both prognostic factors and propensity score. Comparative analyses indicate that treatment with tisagenlecleucel was associated with a statistically significant higher likelihood of achieving CR and lower hazard of death than treatment with blinatumomab. The tisagenlecleucel group exhibited a higher likelihood of CR than the blinatumomab group in every analysis regardless of adjustment approach (odds ratios: 6.71-9.76). Tisagenlecleucel was also associated with a lower hazard of death than blinatumomab in every analysis, ranging from 68% to 74% lower hazard of death than with blinatumomab, determined using multiple adjustment approaches (hazard ratios: 0.26-0.32). These findings support the growing body of clinical trials and real-world evidence demonstrating that tisagenlecleucel is an important treatment option for children and young adults with R/R ALL.
Cardiac toxicity after matched allogeneic hematopoietic cell transplant in the posttransplant cyclophosphamide era
Authors: Yeh Jason , Whited Laura , Saliba Rima M. , Rondon Gabriela , Banchs Jose , Shpall Elizabeth , Champlin Richard , Popat Uday 
Published: October 2021

Abstract
Graft-versus-host disease (GVHD) is one of the leading causes of nonrelapse mortality (NRM) after allogeneic hematopoietic cell transplantation (allo-HCT). Posttransplant cyclophosphamide (PTCy) has shown promise in managing GVHD. However, cyclophosphamide has known cardiac toxicity, and few studies have evaluated the cardiac toxicities that arise after PTCy. We completed a retrospective analysis of patients who underwent matched-donor allo-HCT at our institution and who received PTCy- or non-PTCy–based GVHD prophylaxis, with the goal of determining the incidence of cardiac toxicities up to 100 days after allo-HCT. We included 585 patients in our analysis and found that 38 (6.5%) experienced cardiac toxicity after allo-HCT. The toxicities included arrhythmias (n = 21), heart failure (n = 14), pericardial effusion (n = 10), and myocardial infarction or ischemia (n = 7). Patients who received PTCy had a 7.4% incidence of cardiac toxicity, whereas non-PTCy recipients had an incidence of 5.8% (P = .4). We found that age &gt;55 years (P = .02) and a history of hypertension (P = .01), arrhythmia (P = .003), diabetes (P = .04), and cardiac comorbidities (P &lt; .001) were significant predictors of cardiac toxicity, whereas none of the preparative and GVHD prophylaxis regimens were predictive. From these findings, we proposed the use of a Cardiac Risk Stratification Score to quantify the risk of cardiac toxicity after allo-HCT. We found that a higher score correlated with an incidence of cardiac toxicity. Furthermore, the development of cardiac toxicity was associated with worse 1-year overall survival (OS) and NRM. The use of PTCy was associated with improvements in 1-year OS and NRM rates.
Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation
Authors: Shim Young Jun , Chatterjee Victor , Swaidani Shadi , Alluri Ravi Kumar , Kundu Suman , Merkulova Alona , Angelini Dana , You Dewen , Whitney Samantha A. , Feener Edward P. , Barnard John , Schmaier Alvin H. , Khorana Alok A. , McCrae Keith R. 
Published: October 2021

Abstract
Extracellular vesicles (EV) have been implicated in diverse biological processes, including intracellular communication, transport of nucleic acids, and regulation of vascular function. Levels of EVs are elevated in cancer, and studies suggest that EV may stimulate thrombosis in patients with cancer through expression of tissue factor. However, limited data also implicate EV in the activation of the contact pathway of coagulation through activation of factor XII (FXII) to FXIIa. To better define the ability of EV to initiate contact activation, we compared the ability of EV derived from different cancer cell lines to activate FXII. EV from all cell lines activated FXII, with those derived from pancreatic and lung cancer cell lines demonstrating the most potent activity. Concordant with the activation of FXII, EV induced the cleavage of high molecular weight kininogen (HK) to cleaved kininogen. We also observed that EVs from patients with cancer stimulated FXII activation and HK cleavage. To define the mechanisms of FXII activation by EV, EV were treated with calf intestinal alkaline phosphatase or Escherichia coli exopolyphosphatase to degrade polyphosphate; this treatment blocked binding of FXII to EVs and the ability of EV to mediate FXII activation. In vivo, EV induced pulmonary thrombosis in wild-type mice, with protection conferred by a deficiency in FXII, HK, or prekallikrein. Moreover, pretreatment of EVs with calf intestinal alkaline phosphatase inhibited their prothrombotic effect. These results indicate that polyphosphate mediates the binding of contact factors to EV and that EV-associated polyphosphate may contribute to the prothrombotic effects of EV in cancer.
“The balloon was just the kick start, I had to do the rest myself”: Adolescents living with severe obesity experiences of an intra-gastric balloon alongside a lifestyle support programme
Authors: Reece Lindsey J. , Bissell Paul , Sachdev Pooja , Wright Neil , Mihrshahi Seema , Copeland Robert J. 
Published: October 2021

Abstract
Background
Few treatments exist for adolescents living with severe obesity. This qualitative study explored the experiences of severely obese adolescents and their families who participated in the BOB study.

Methods
Twelve adolescents (5 males;7 females; mean age 15 years; BMI > 3.5 s.d; puberty stage 4 +) who were engaged with the research study BOB (a non-randomised, pilot novel obesity treatment programme that involved the insertion of an intra-gastric balloon coupled with a family lifestyle behavioural support programme). Adolescents attended weekly lifestyle sessions before, during and post balloon insertion. All participants were interviewed at 3 months, (halfway through intra-gastric balloon insertion) and at 12 months follow-up (6 months post intra-gastric balloon removal, 3 months post lifestyle intervention).

Results
All BOB participants had exhausted all treatment options deeming this study their final option. Many alluded to feelings of desperation and referred to a sense of hope that this intervention would be effective. Family involvement and attendance within the structured sessions differed significantly. Adolescents and parents perceived support from the research study ceased when the intra-gastric balloon was removed at 6-months despite attendance post balloon removal being poor. All participants emphasised a need for further support longer term with the integration of the family a critical factor.

Conclusions
Further research is needed to explore the specific role families play within treatment to optimise health and wellbeing outcomes. Adolescents perspectives should be integrated within treatment to inform and improve the effectiveness of future treatment programmes for severely obese adolescents and their families.