bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery: Analysis of Effect and Prognostic Factors
Authors: Yan Junfang , Zheng Ziye , Zhu Jiawei , Hu Ke , Hou Xiaorong , Shen Jie , Lian Xin , Sun Shuai , Miao Zheng , Shen Jing , Guan Hui , Meng Qingyu , Zhang Fuquan 
Published: September 2021

ObjectiveThe role of salvage radiotherapy (RT) in the treatment for vaginal recurrence of cervical cancer in patients after prior surgery remains controversial. The aim of this study was to evaluate the efficacy and toxicity of salvage RT and explore prognostic factors associated with the survival after recurrence.MethodsPatients with cervical cancer, treated for vaginal recurrences at Peking Union Medical College Hospital between July 2011 and November 2019, were identified. All the patients underwent prior surgery for primary tumor and received salvage RT including external beam radiotherapy (EBRT), brachytherapy (BT), or both. The irradiation field and dose depended on the conditions of patients. Recurrence patterns were classified into four categories according to the site of recurrence. Prognostic factors on the overall survival (OS), progression-free survival (PFS), and local control (LC) were analyzed, and late toxicity was evaluated.ResultsA total of 141 patients were included in the analysis, with a median follow-up time of 40.8 months. The estimated 5-year OS, PFS, and LC rates were 81%, 75%, and 87%, respectively. In multivariate analysis, endovaginal recurrence and no irradiation history were favorable prognostic factors associated with OS (all p &lt; 0.05), PFS (all p &lt; 0.05), and LC (all p &lt; 0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of the recurrence pattern is larger than the stage of primary tumor (0.734 vs. 0.670).ConclusionsRT was an effective treatment with tolerable toxicity for vaginal recurrences of cervical cancer in patients with prior surgery. Recurrence pattern and irradiation history were important prognostic factors.
Efficacy and Safety of Fospropofol Disodium for Injection in General Anesthesia Induction for Adult Patients: A Phase 3 Trial
Authors: Wu Chao-Meng , Zhang Wen-Sheng , Liu Jin , Zhang Wei-Yi , Ke Bo-Wen 
Published: September 2021

Background:Fospropofol disodium for injection (FospropofolFD) is a prodrug that is metabolized into propofol to produce a general anesthesia effect when administered intravenously.Objective:This study aimed to assess the efficacy and safety of FospropofolFDin comparison with propofol medium/long-chain fat emulsion injections (propofol-MCT/LCT) for general anesthesia induction in adult patients undergoing elective surgeries.Setting:Nine academic medical centers in China.Method:This multicenter, randomized, double-blind, double-simulated, controlled, and non-inferiority trial evaluated 540 eligible adult patients randomly assigned (2:1) to the intervention (20 mg/kg FospropofolFD) or control (2 mg/kg propofol-MCT/LCT) groups.Main Outcome Measure:The primary efficacy endpoint was the success rate, defined as a Modified Observer’s Assessment of Alertness/Sedation Scale score of 1 within 5 min after study drug administration. The safety endpoints consisted of adverse events (AEs) related to consciousness, cognitive function, hemodynamic status, liver and kidney function, and blood tests.Results:A total of 347 (96.3%) and 175 (97.2%) patients in the intervention and control groups, respectively, completed the study. The success rate for the primary outcome was 97.7% for both study drugs. The most frequent AEs in the intervention group were abnormal feeling (62.0%), blood pressure reduction (13.5%), and injection site pain (13.3%). No AEs related to consciousness and mental and cognitive functions or serious adverse events were reported.Conclusion:FospropofolFD(20 mg/kg) is not inferior to propofol-MCT/LCT (2 mg/kg) in general anesthesia induction for American Society of Anesthesiologists (ASA) physical status I-II adult patients undergoing elective surgeries. It is safe and effective for clinical use under anesthesiologist monitoring.Impact on Practice Statement:FospropofolFDcan produce a general anesthesia effect and reduce the incidence of pain at the site of injection.
Serum Amyloid Biomarkers, Tau Protein and YKL-40 Utility in Detection, Differential Diagnosing, and Monitoring of Dementia
Authors: Wilczyńska Karolina , Maciejczyk Mateusz , Zalewska Anna , Waszkiewicz Napoleon 
Published: September 2021

Introduction: The diagnosis and treatment of dementia is one of the greatest challenges in contemporary health care. The widespread use of dementia biomarkers would improve the quality of life of patients and reduce the economic costs of the disease. The aim of the study was to evaluate the usefulness of proteins related to the Alzheimer's disease pathogenesis—amyloid beta isoform (Aβ) and total tau protein (t-tau), as well as the quite recently discovered marker YKL-40 in the most common types of dementia.Methods: 60 dementia (AD—Alzheimer's disease, VaD—vascular dementia, MxD—mixed dementia) and 20 cognitively normal subjects over 60 years old were examined. Subjects with dementia of etiology different than AD or VaD and with neoplastic or chronic inflammatory diseases were excluded. Concentrations of Aβ40, Aβ42, t-tau, and YKL-40 were measured in serum using ELISA kits on admission and after 4 weeks of inpatient treatment. ANOVA and Tukey's test or Dunn's test were used to perform comparison tests between groups. Correlations were measured using Pearson's coefficient. Biomarker diagnostic utility was assessed with ROC analysis.Results: YKL-40 differentiates between cognitively normal and mild dementia patients with 85% sensitivity and specificity and t-tau with 72% sensitivity and 70% specificity. YKL-40 and t-tau concentrations correlate with each other and with the severity of clinically observed cognitive decline.Conclusions: YKL-40 is a sensitive and specific biomarker of early dementia and, to a lesser extent, of dementia progression, however, many comorbidities may influence its levels. In such conditions, less specific but still reliable t-tau may serve as an alternative marker. Obtained results did not confirm the diagnostic utility of amyloid biomarkers.
Rubella Serosurvey Among Future Healthcare Workers
Authors: Trevisan Andrea , Mason Paola , Nicolli Annamaria , Maso Stefano , Bertoncello Chiara 
Published: September 2021

Objective: Rubella is a very diffusive but relatively benign infectious disease unless contracted during pregnancy, when it causes congenital rubella syndrome. The aim of this research was to determine the prevalence and titer of antirubella antibodies in a population of future healthcare workers (students at the school of medicine).Methods: The cohort consisted of 11,022 students who underwent antibody analysis after the presentation of a vaccine certificate.Results: Vaccination compliance was very high, particularly in younger students (born after 1995), reaching almost 100% (at least one dose). Unvaccinated students born before 1990 had high seropositivity (&gt;95%), but this percentage dropped to zero among the youngest students. Variables affecting antibody titer included year of birth and sex. Considering only vaccinated students, a greater antibody response was observed if the vaccine was administered between 8 and 10 years of age. Female sex was associated with more significant (p &lt; 0.0001) positivity and higher antibody titer after one and two doses. However, this difference appeared less consistent in relation to year of birth.Conclusions: The studied population exhibited excellent vaccination compliance, high seropositivity, and high antibody titer. Vaccine and immune coverage were higher than what is deemed necessary to achieve herd immunity.
Radial Sizes and Expansion Behavior of ICMEs in Solar Cycles 23 and 24
Authors: Mishra Wageesh , Doshi Urmi , Srivastava Nandita 
Published: September 2021

We attempt to understand the influence of the heliospheric state on the expansion behavior of coronal mass ejections (CMEs) and their interplanetary counterparts (ICMEs) in solar cycles 23 and 24. Our study focuses on the distributions of the radial sizes and duration of ICMEs, their sheaths, and magnetic clouds (MCs). We find that the average radial size of ICMEs (MCs) at 1 AU in cycle 24 is decreased by ∼33% (∼24%) of its value in cycle 23. This is unexpected as the reduced total pressure in cycle 24 should have allowed the ICMEs in cycle 24 to expand considerably to larger sizes at 1 AU. To understand this, we study the evolution of radial expansion speeds of CME-MC pairs between the Sun and Earth based on their remote and in situ observations. We find that radial expansion speeds of MCs at 1 AU in solar cycles 23 and 24 are only 9% and 6%, respectively, of their radial propagation speeds. Also, the fraction of radial propagation speeds as expansion speeds of CMEs close to the Sun are not considerably different for solar cycles 23 and 24. We also find a constant (0.63 ± 0.1) dimensionless expansion parameter of MCs at 1 AU for both solar cycles 23 and 24. We suggest that the reduced heliospheric pressure in cycle 24 is compensated by the reduced magnetic content inside CMEs/MCs, which did not allow the CMEs/MCs to expand enough in the later phase of their propagation. Furthermore, the average radial sizes of sheaths are the same in both cycles, which is also unexpected, given the weaker CMEs/ICMEs in cycle 24. We discuss the possible causes and consequences of our findings relevant for future studies.
Quality and Oxidative Changes of Minced Cooked Pork Incorporated with Moringa oleifera Leaf and Root Powder
Authors: Lungu Nobuhle S. , Afolayan Anthony J. , Thomas Ronald S. , Idamokoro Emrobowansan M. 
Published: September 2021

Consumers are currently demanding meat products produced using natural additives due to their potential health benefits. Consequently, there has been a progressive interest in the search for more natural antioxidant sources. The aim of this study was to evaluate the effect of varying levels of M. oleifera root and leaf powder on the oxidative stability and quality of cooked minced pork during eight days of refrigerated storage at 4 °C. The leaves contained significantly higher (p ˂ 0.05) concentrations of total phenols (50.08 ± 0.01 mg GAE/g), while the roots contained the highest amounts of flavonoids (375.15 ± 0.19 mg QE/g) and proanthocyanidins (132.62 ± 0.4 mg CE/g). Both plant parts demonstrated good 2,2-Diphenyl-2-picrylhydrazyl (DPPH) and 2,2 íazino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) free radical scavenging activity. Minced cooked pork incorporated with M. oleifera leaf and root powder had significantly lower pH and thiobarbituric acid-reactive substances (TBARS) values compared to the control (p < 0.05). The ferric reducing antioxidant power (FRAP) was also significantly higher in the samples that incorporated antioxidants compared to the control (p < 0.05). Findings from this study suggest that M. oleifera leaves and roots are potent antioxidant sources which can be incorporated in meat to improve quality attributes during storage.
ACTIVITY OF THE ART STUDIES DEPARTMENT IN POLTAVA INSTITUTE OF PUBLIC EDUCATION IN THE PERIOD FROM 1921 TO 1933 YEAR
Authors: Dem’yanko Natalija 
Published: September 2021

The article outlines the essence of the activity of the Department of Art Studies in Poltava Institute of Public Education (INO) for the training of pedagogical staff in the period from 1921 to 1933. The material and organizational-methodical conditions of its creation and functioning under direction of the famous Ukrainian musicologist, teacher, ethnographer, choreographer, conductor and composer V. M. Verkhovinets are revealed. The main directions of department's activity are described: musical- theoretical, conductor-choir, instrumental-performing, methodical training of future teachers; organization of research work and pedagogical practice of students in various educational institutions; preparation of concert programs and performances of student choir and other amateur art groups; conducting active public and cultural- mass work within the educational institution, city and region. The forms of educational process organization, including lecture classes, laboratory and scientific workshops, scientific observations and experiments, practice of teaching, studying of techniques, textbooks, scientific and educational and popular literature of corresponding specialties, labor practices, holding of student conferences for discussion of practical results are determined. The features of organization and diverse activities (educational, rehearsal, concert) of student choir in Poltava INO are revealed. Methods and principles (scientific, systematic, consistency, accessibility, visibility, unity of theory and practice of teaching educational disciplines are revealed).
SPIRITUALITY IN THE EDUCATIONAL TRADITION OF HUMANISTS OF THE EPOСHE OF THE EUROPEAN REVIVAL (END OF XIV – XVI CENTURY)
Authors: Hod Borys , Hod Nataliia 
Published: September 2021

In connection with the integration of Ukraine into the European community, there is a need for a more substantive study of the European experience of education and upbringing, in particular the legacy of representatives of «Christian humanism». European humanism had a common Renaissance foundation, but the emphasis in different currents did not coincide.The religious and philosophical movement «devoteo moderna» (founder G. Grote) was propagated in Germany and the Netherlands. Its representatives supported the individualization of education, moral perfection of the individual through persistent mental and emotional work, «imitation of Christ», reading religious literature, caring for the sick and the unable. They had an initiative to establish fraternal schools, and later – the organization of book printing.The main propagandist of the ideas of spirituality in England became the group of «Oxford intellectuals (reformers)» (V. Grossin, J. Colet, V. Lilly, T. Linekr, etc.). The group developed the idea of renewal of society through enlightenment, propaganda of morality on the model of Gospel and practices of early Christianity.J. Kolet called for the restoration of the true meaning of the teachings of Christ by addressing the project of creating a new grammatical school with a humanistic program of education and upbringing.T. Moore and H. Vives continued the ideas of Pico della Mirandolly, partly Gallic priests-druids. T. Moore linked the spiritual development of a person with the socio-political transformations of society on the basis of «true» Christian ethics in the mould of the doctrine of Christ, a broad tolerance. The teaching of children in the state of utopians was practiced by priests as «"guardians of traditions».«Philosophy of Christ» by Erasmus of Rotterdam was formed under the influence of «new piety», the ideas of J. Kolet, Florentine Neoplatonism and early Christian patristic literature. He believed that ritualism should not interfere with the true meaning of Christ's doctrine, urged as soon as possible to begin the upbringing of a Christian, to maintain self-perfection through reflection and confession. «Mentor of Europe» offered the actual ethical principles and values for the present.In our time, when searches for new forms and methods of spiritual and moral education in the conditions of overcoming the spiritual crisis are conducting, it is useful to apply to the pedagogical ideas and experience of humanists of the epoch of the European Renaissance, verified by centuries of practice.
Enhanced decomposition of toxic pollutants by underwater pulsed discharge in the presence of hydrogen peroxide and microbubbles
Authors: Matsuura Risako , Kometani Noritsugu , Horibe Hideo , Shirafuji Tatsuru 
Published: September 2021

Abstract
The decomposition of phenol and 4-chlorophenol by underwater pulsed discharge has been examined. The addition of hydrogen peroxide improved the decomposition rate of phenol by about 2.5 times and that of 4-chlorophenol by about 1.5 times. Analysis using a fluorescent probe suggested that the addition of hydrogen peroxide enhanced the production of hydroxyl radicals by about 3 times. We have also examined the effect of using microbubbles on the decomposition of phenol. The use of only microbubbles resulted in a slight increase of the decomposition rate, while the use of both microbubbles and hydrogen peroxide led to a remarkable enhancement of the decomposition rate by about 3.5 times with the conversion of phenol reaching 70% at discharge time of 3 h, which corresponded to the energy yield of 4.39 × 10–9 mol J−1.
Preparation of iron nanosized powder by pulsed wire discharge
Authors: Suematsu Hisayuki , Hayashi Yoshiki , Hieu Nguyen Duy , Dung Do Thi Mai , Nakayama Tadachika 
Published: September 2021

Abstract
Organic matter coated Fe nanosized powders were prepared by pulsed wire discharge. X-ray diffraction showed no crystalline phases except for α-Fe. Transmission electron microscopy (TEM) and infrared absorption spectroscopy results indicated that the prepared particles were coated by mineral oil. From the TEM results, the particle size distributions were also obtained and the geometric mean diameters were calculated to be from 20.2 to 42.4 nm. The relation between the geometric mean diameter and theoretical plasma/vapor density was close to that predicted by the known particle size determining equation. Saturation magnetization as high as 172 emu g−1 was obtained for the prepared Fe nanosized powder.
Characterization of Nd: LaVO4 single-crystal scintillator emitting near-infrared photons
Authors: Akatsuka Masaki , Nakauchi Daisuke , Kato Takumi , Kawaguchi Noriaki , Yanagida Takayuki 
Published: September 2021

Abstract
Nd: LaVO4 single crystals were prepared and were evaluated for their photoluminescence (PL) and radioluminescence properties. The 0.1% Nd-doped LaVO4 single crystals showed the highest PL quantum yield (36.3%) of all the samples. Regarding the scintillation properties, the Nd-doped samples showed scintillation peaks at around 900, 1060, and 1320 nm owing to the electronic transition of Nd3+. In addition, we estimated the correlation between the scintillation signal intensity and the exposure dose rate of the X-ray in the spectral range from 900 nm through 1600 nm. Among all the samples, the 3.0% Nd-doped sample had the highest sensitivity.
Design and fabrication of photonic crystal resonators for single-mode and vertical surface emission from strain-compensated quantum cascade lasers operating at 4.32 μm
Authors: Saito Shinji , Hashimoto Rei , Kaneko Kei , Kakuno Tsutomu , Yao Yuanzhao , Ikeda Naoki , Sugimoto Yoshimasa , Mano Takaaki , Kuroda Takashi , Tanimura Hirotaka , Takagi Shigeyuki , Sakoda Kazuaki 
Published: September 2021

Abstract
Photonic crystal resonators with the C4v symmetry were designed and fabricated on quantum cascade lasers with a strain-compensated multiple quantum well to achieve single-mode and vertical surface emission at 4.32 μm. Their fabrication accuracy was confirmed by high-resolution reflection spectroscopy. The maximum output power was 10 mW at 77 K. A far-field pattern with a small divergence angle below 1 degree was observed. Its main peak had a donut shape, which was attributed to the spatial symmetry of the resonance mode of the photonic crystal.
Platinum and gold placer from Tugidak Island, Alaska: Platinum-group minerals and their inclusions, gold, and chromite mineralogy
Authors: Belkin Harvey E. , Grosz Andrew E. 
Published: September 2021

ABSTRACT
Black sand beach placers from Kodiak, Sitkinak, and Tugidak Islands, Alaska, have been mined intermittently for gold and minor platinum-group alloys for more than 100 years. High-grade platinum-rich magnetic separate and accompanying black sand from the southern beach placer of Tugidak Island were studied using electron microprobe WDS and scanning electron microscope EDS; mineral classification and identification were based on these techniques. The major platinum mineral is isoferroplatinum, followed by minor tetraferroplatinum and tulameenite, and rare ferronickelplatinum. Two types of alteration were identified in about 3–4% of the alloy grains: rim formation involving Pt loss and increased Fe, Ni, and/or Cu, and fracturing and vein filling by Cu-rich alloy. Ruthenium-Ir-Os-Pt alloys occur as inclusions and veins as well as form part of composite grains. Ten percent of the alloy grains contain a large variety of platinum-group minerals (PGM). Inclusions of cuprorhodsite, malanite, cuproiridsite, laurite, erlichmanite, cooperite, braggite, bowieite, kashinite, miassite, hollingworthite, irarsite, sperrylite, stillwaterite, genkinite, stibiopalladinite, keithconnite, zvyagintsevite, and probable palladodymite and vincentite were identified. Two unidentified inclusion phases also occur. Most of the PGM inclusions are primary and were trapped by a growing crystal from a melt; some inclusions exhibit textures that suggest trapping of an As,Te,S-rich immiscible melt. Secondary inclusions and evidence of deformation were observed in a few alloy grains. Associated with PGM inclusions or as separate inclusions are various base-metal sulfides. Two silicate-melt inclusions in one isoferroplatinum grain have an andesite–shoshonite composition. Minor gold and Ag-rich gold in the high-grade magnetic separate contain magnetite, pyrrhotite, and chromite inclusions. The gold composition suggests that their sources are the numerous quartz veins and apophyses related to granitoids on Kodiak Island. The composition of the placer chromite is similar to chromite from the Border Ranges mélange fault system and suggests that the Uyak Complex ultramafic and mafic rocks are part of a supra-subduction-zone ophiolite and are the source of the platinum-group minerals.
Presentation of Russian quantitative adverbs for foreign students: the system of exercises. Part 2. Lexemes немного, мало and their derivatives
Authors: Панков Ф.И. , Гулидова Е.Н. 
Published: September 2021

В статье рассматриваются особенности представления русской адвербиальной лексики в иноязычной аудитории. В результате функционально-коммуникативного анализа квантитативов немного, мало и мотивированных ими лексем было создано их интегральное лингводидактическое описание. Оно послужило основой для разработки системы упражнений и заданий (СУЗ), направленных на обучение инофонов корректному употреблению названных лексем в речи. Фрагмент разработанной СУЗ представлен в данной статье.
The articles deals with the peculiarities of presenting Russian adverbs at the lessons of Russian as a foreign language. The results of the functional communicative analysis of quantitative words немного, мало, and their derivatives carried out by the authors allowed to create the integral linguodidactic description of the chosen words. This description laid the foundation for the working-out of a system of exercises aimed at teaching foreign students the correct use of the above-said lexical items in their speech. The article presents the fragment of this system.