bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation the performance of conventional water-based mud characteristics by applying Zinc Oxide and Silica Dioxide Nanoparticles materials for a selected well in The Kurdistan/ Iraq
Authors: AlBajalan Ahmed Rafiq , Haias Huner 
Published: May 2021

Abstract
Nanomaterials have gained a wide interest in the oil and gas industry due to its immense applicability. Nanomaterial is being used for formulating a new generation of drilling mud which is known as Nano- mud. Where it has the ability to improve mud properties and eliminate bore hole problems. Using nanoparticles as an additive agent in conventional drilling mud can lead to a more efficient drilling process in troublesome formations. In this experimental study, several conventional water-based muds from a selected well drilled in the Kurdistan / Iraq oil field have been prepared. Then nano-drilling muds were formulated by dispersing SiO2 and ZnO nanoparticles in concentrations ranging from (0.25 to 1 wt.%) to conventional water-based mud (WBM). The objective of this experimental study is evaluating and comparing the performance of conventional water-based muds after adding SiO2 and ZnO nanoparticles. This comparison was performed by carrying out a series of laboratory experiments to determine the rheological and mud filtrate properties. The results demonstrated that adding SiO2 and ZnO NPs to conventional water-based mud improved the rheological behavior and provided better filtration control compared to conventional drilling muds. However, there was little or no impact of nanomaterials on the mud density for all mud systems.
Combined small cell lung carcinoma with pulmonary adenocarcinoma
Authors: shen cheng , Guowei Che 
Published: May 2021

Abstract
Background

Combined SCLC is defined as SCLC combined with an additional component that consists of any of the histological types of non-SCLC, usually squamous cell carcinoma or large cell carcinoma. CSCLC contains adenocarcinoma is extremely rare and has been reported to account for less than 1–3% of CSCLC.
Case presentation:

We report a case with a rare and surgically treated CSCLC with adenocarcinoma in an elderly and concerned with the clinical features of this disease. The patient has remained well for over 2 weeks after the treatment without any signs of disease recurrence.
Conclusion

Combined small cell carcinoma is uncommon, but is nevertheless a well-described diagnostic category in lung cancers. To facilitate the preoperative diagnosis and avoid the misdiagnosis of such rare disease, more cases will need to be reported.
Experimental Investigation on Map-Environment Disparity to the Performance of Image-Retrieval-Based Localization
Authors: Takahashi Junji , Shimmra Kohei , Yu Yong , Shibata Akihiro , Sakamoto Toshiaki 
Published: May 2021

Abstract
This paper deals with a problem of map-based localization. When a robot has a pre-constructed map of an environment and explores there with sensing, the localization problem boils down to the problem of finding the closest data pattern to the sensing data from the map. Although, the map quality as well as the sensing data quality greatly affects to the localization performance, however it has been rarely discussed up to this point. To study the influence of the map quality to the localization performance, we propose a simulational experiment using an architectural 3D CAD models. We prepared a precisive 3D CAD model imitating a corridor of elementary school and generated a 3D wireframe map and virtual sensing images from the CAD model. The precisive 3D CAD model is regarded as the ground-truth data through the whole experiments. Then, we prepared several levels of broken maps with randomly shifted joinery parts such as, doors and windows. For localization process, our previously developed image-retrieval based localization method is used. Totally 3,500 number of localization experiments are conducted with various broken map setting. We show the influence of map-environment disparity to the localization performance by comparing these experimental results and discuss the requirements of map quality.
Different Montages of Transcranial Direct Current Stimulation on Dual-Task Walking and Cortical Activity in Chronic Stroke: Double-Blinded Randomized Controlled Trial
Authors: Wong Pei-Ling , Yang Yea-Ru , Tang Shun-Chang , Huang Shi-Fong , Wang Ray-Yau 
Published: May 2021

Abstract
Background: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation to modulate cortical activity for improving motor function. However, the different tDCS applications for modulating cortical activity and dual task gait performance in chronic stroke have not yet been investigated. This study investigated the effects of different tDCS applications on dual task gait performance and contralesional M1 activation in chronic stroke.Methods: Forty-eight participants were randomized to anodal, bilateral, cathodal, and sham tDCS groups. Each group received 20 mins of tDCS stimulation, except the sham group. Gait performance was measured by GaitRite system during cognitive dual task (CDT) walking, motor dual task (MDT) walking, and single walking (SW). Contralesional M1 activity of unaffected tibialis anterior (TA) was measured using transcranial magnetic stimulation (TMS). Intragroup difference was analyzed by Wilconxon sign ranks test with Bonferroni correction, and Kruskal-Wallis one-way analysis of variance by ranks was used for intergroup comparisons, followed by post-hoc Mann-Whitney U tests with Bonferroni correction.Results: The bilateral tDCS (p=0.017) and cathodal tDCS (p=0.010) improved the CDT walking speed more than sham group. The bilateral tDCS (p=0.048) and cathodal tDCS(p=0.048) also improved the MDT walking speed more than sham group. Furthermore, bilateral tDCS (p=0.012) and cathodal tDCS (p=0.040) increased the silent period (SP) more than the anodal and sham group. Thus, one-session of bilateral and cathodal tDCS improved dual task walking performance paralleled with increasing contralesional corticomotor inhibition in chronic stroke.Conclusions: Our results indicate that one-session of bilateral and cathodal tDCS increased contralesional corticomotor inhibition and improved dual task gait performance in chronic stroke. Trial registration: Thai Clinical Trials Registry (TCTR20180116001). Registered on 16th Jan, 2018.
­­­­GMP-conform production of [ 68Ga ]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor
Authors: Pretze Marc , Reffert Laura , Diehl Steffen , Schönberg Stefan O. , Wängler Carmen , Hohenberger Peter , Wängler Björn 
Published: May 2021

Abstract
Background: [68Ga]Ga-NeoB is a novel DOTA-coupled Gastrin Releasing Peptide Receptor (GRPR) antagonist with high affinity for GRPR and good in vivo stability. This study aimed at (1) the translation of preclinical results to the clinics and establish the preparation of [68Ga]Ga-NeoB using a GMP conform kit approach and a licensed 68Ge/68Ga generator and (2) to explore the application of [68Ga]Ga-NeoB in patients with gastrointestinal stromal tumors (GIST) before and/or after interventional treatment (selective internal radiotherapy, irreversible electroporation, microwave ablation).Results: Validation of the production and quality control of [68Ga]Ga-NeoB for patient use had to be performed before starting the GMP production. Six independent batches of [68Ga]Ga-NeoB were produced, all met the quality and sterility criteria and yielded 712 ± 73 MBq of the radiotracer in a radiochemical yield of >50%, a radiochemical purity of >95% and a molar activity of 14.2 ± 1.5 GBq/µmol within 20 min synthesis time and additional 20 min quality control. Three patients (2 females, 1 male, 51–77 yrs of age) with progressive gastrointestinal stromal tumor metastases in the liver or peritoneum not responsive to standard tyrosine kinase inhibitor therapy underwent both [68Ga]Ga-NeoB scans prior and after interventional therapy. Radiosynthesis of 68Ga-NeoB was performed using a kit approach under GMP conditions. No specific patient preparation such as fasting or hydration was required for [68Ga]Ga-NeoB PET/CT imaging. Contrast-enhanced PET/CT studies were performed. A delayed, second abdominal image was acquired at 120 minutes p.i. of admistration of the first dose of [68Ga]Ga-NeoB.Conclusions: A fully GMP compliant kit preparation of [68Ga]Ga-NeoB enabling the routine production of the tracer under GMP conditions was established for clinical routine PET/CT imaging of patients with metastatic GIST and proved to adequately visualize tumor deposits in the abdomen expressing GRPR. Patients could benefit from additional information derived by [68Ga]Ga-NeoB diagnosis to assess the presence of GRPR in the tumor tissue and monitor antitumor treatment.
Radiolabeling of Iranian Androctonus crassicauda Scorpion Venom with Technetium-99m for Biological Studies
Authors: Yekany Leila Valipour , Mofrad Farshid Babapour , Shirmardi Seyed pezhman , Erfani Mostafa , Mirakabadi Abbas Zare 
Published: May 2021

Abstract
Background: Androctonus crassicauda has a neurotoxin venom that can affect most of the vital organs of the body and result in death. In this study 99mTc-labeling and biological evaluation of Androctonus crassicauda scorpion venom are described.Method: In this research, Toxic fraction of this venom was labelled with 99mTc. Radiochemical purity of the labelled toxic fraction was obtained by using chromatographic system. Animal biodistribution studies were performed after injection of labelled compound into normal rats.Results: Radiochemical purity was obtained more than 90%. Biodistribution studies in normal rats showed moderate clearance of blood circulation system. The results of the study indicated that scorpion venom labeling with 99mTc can be a useful tool for the biodistribution and kinetic studies of the venoms for clinical use.
Long-term outcome of postpartum psychosis: a prospective clinical cohort study in 106 women
Authors: Rommel Anna-Sophie , Molenaar Nina Maren , Gilden Janneke , Kushner Steven A. , Westerbeek Nicola J. , Kamperman Astrid M. , Bergink Veerle 
Published: May 2021

Abstract
Objective: We aimed to investigate the outcome of postpartum psychosis over a four-year follow-up, and to identify potential clinical markers of mood/psychotic episodes outside of the postpartum period. Methods: One hundred and six women with a diagnosis of first-onset mania or psychosis during the postpartum period were included in this prospective longitudinal study. Women were categorized into either 1) recurrence of non-postpartum mood/psychotic episodes or 2) mania/psychosis limited to the postpartum period. We summarize the longitudinal course of the illness per group. We used a logistic regression model to identify clinical predictors of recurrence of mood/psychotic episodes outside of the postpartum period. Results: Over two thirds of the women included in this study did not have major psychiatric episodes outside of the postpartum period during follow-up. The overall recurrence rate of mood/psychotic episodes outside the postpartum period was ~33%. Of these women, most transitioned to a bipolar disorder diagnosis. None of the women fulfilled diagnostic criteria for schizophrenia or schizophreniform disorder. No clinical markers significantly predicted recurrence outside of the postpartum period. Conclusions: For the majority of women with first-onset postpartum psychosis, the risk of illness was limited to the period after childbirth. For the remaining women, postpartum psychosis was part of a mood/psychotic disorder with severe non-postpartum recurrence, mainly in the bipolar spectrum. No clinical predictors for risk of severe episodes outside the postpartum period emerged. Our findings add to previous evidence suggesting a fundamental link between postpartum psychosis and bipolar disorder, which may represent two distinct diagnoses within the same spectrum.
REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical multicentre trial
Authors: Brede Jostein Rødseth , Skulberg Arne Kristian , Rehn Marius , Thorsen Kjetil , Klepstad Pål , Tylleskär Ida , Farbu Bjørn , Dale Jostein , Nordseth Trond , Wiseth Rune , Krüger Andreas Jørstad 
Published: May 2021

Abstract
Background Survival after out-of-hospital cardiac arrest (OHCA) is poor and dependent on high-quality cardiopulmonary resuscitation. Resuscitative endovascular balloon occlusion of the aorta (REBOA) may be advantageous in non-traumatic OHCA due to the potential benefit of redistributing the cardiac output to organs proximal to the aortic occlusion. This theory is supported by data from both preclinical studies and human case reports. Methods This multicentre trial will enrol 200 adult patients, who will be randomised in a 1:1 ratio to either a control group that receives advanced cardiovascular life support (ACLS) or an intervention group that receives ACLS and REBOA. The primary endpoint will be the proportion of patients who achieve return of spontaneous circulation with a duration of at least 20 minutes. The secondary objectives of this trial are to measure 30-day survival with good neurological status, to describe the haemodynamic physiology of aortic occlusion during ACLS, and to document adverse events. Discussion Results from this study will assess the efficacy and safety of REBOA as an adjunctive treatment for non-traumatic OHCA. This novel use of REBOA may contribute to improve treatment for this patient cohort. Trial registration The trial is approved by the Regional Committee for Medical and Health Research Ethics in Norway (reference 152504) and is registered at ClinicalTrials.gov (reference NCT04596514) and as Universal Trial Number WHO: U1111-1253-0322.
Highly Hydrophilic Ultrafiltration Membranes Synthesized From Acrylic Acid Grafted Polyethersulfone For Downstream Processing Of Therapeutic Insulin And Cobalamin
Authors: Nandala Shiva Prasad , Nimmagadda Lakshmi Gayatri , Bala Naga Sandhya , Swayampakula Kalyani , Sundergopal Sridhar 
Published: May 2021

Abstract
The significance of the present study is to purify small therapeutic biomolecules such as urea, cobalamin, and insulin of molecular weights below 10 kDa through surface grafted polyethersulfone (PES) ultrafiltration (UF) membranes. The membranes were synthesized by adding an additive of 6 kDa polyethylene glycol (PEG) and grafted with acrylic acid (AA) by varying the concentrations from 2 to 6 wt. % under UV-induce phtocataltic reaction. These membranes were characterized by various tools such as Scanning electron microscope ((SEM), Fourier transforms infrared spectra (FTIR), thermogravimetric analysis (TGA), and contact angle for membrane morphological, structural, thermal stability, and hydrophilicity, respectively. The degree of grafting and their MWCOs of the indigenous membranes were analyzed using various molecular weight solutions of PEG. After PEG doping, the PWF of the membrane was enhanced to 41.50 L m− 2 h− 1 for PES [6+] [0], and a similar trend was also observed for the PEG doped PES grafted membranes. From the experimental results, the synthesized membranes of additive loaded with 5 and 6 wt. % AA grafted PES reject 90 % of the insulin and cobalamin. The results are found to be in correlation with the MWCO values of these membranes ranging from 1 to 10 kDa. From the overall characterization and experimental observations, it can be confirmed that these indigenously synthesized flat sheet grafted membranes showed excellent permeabilities and higher % rejection towards the therapeutic biomolecules.
Effect of Monotherapy Weifuchun Tablets on Chronic Atropic Gastritis: A Randomized Controlled Trial
Authors: He Jiamin , Shen Weiyi , Zhang Yawen , Hu Mengjia , Fang Yanfei , Deng Yanyong , Chen Shujie , Wang Lan , Mo Jianling 
Published: May 2021

Abstract
Background and Aim:

Chronic atrophic gastritis is a common gastric disease which shows a positive correlation with the occurrence of gastric cancer. Traditional chinese medicines have been used in the treatment of chronic atrophic gastritis. There is no solid evidence for the curative effects of traditional chinese medicines. This study aimed to investigate the clinical efficacy of Weifuchun tablets on patients with chronic atrophic gastritis.
Methods

97 patients of chronic atrophic gastritis without current H. pylori infection were divided into two groups: an experiment group treated with Weifuchun and a control group treated with teprenone and folic acid for six months. Pathological examination of gastric biopsies and clinical symptoms assessment were performed for all patients before and after treatments. Primary outcome was the pathological response rate in each group evaluated by changes of histological scores.Secondary outcome was the clinical symptom scores.
Results

Twenty four patients in the Weifuchun group and twenty eight patients in the control group completed the study. The pathological response rates for atrophy and intestinal metaplasia were 66.7% and 45.8% in the Weifuchun group and 66.7% and 42.9% in the folic acid group, respectively, without statistical significance between groups.Clinical symptoms failed to improve after treatments in either group.
Conclusions

Weifuchun is effective to improve pathological changes of chronic atrophic gastritis in patients without current H. pylori infection. Monotherapy of Weifuchun had a similar efficacy to the combined therapy by teprenone and folic acid in the treatment of chronic atrophic gastritis.
Trial registration:

Evaluation of Weifuchun Pills on chronic atrophic gastritis, ChiCTR-IPR-17013939, Registered 15 December 2017, http://www.chictr.org.cn/ showproj.aspx?proj = 23910.
Identical Shapes Results in a Failed Memory Formation of Location of Dark Surroundings in Planarians
Authors: Huang Kaiyuan 
Published: May 2021

Abstract
Planarians, the first kind of animal to have evolved a brain structure yet has not evolved vision, were demonstrated to have a capability of spatial learning in the last several decades, but what does the navigation of planarians depends on is still unknown. Here, we provide an objective, strictly variable-controlled planarian training method using 3D printing techniques fabricated mazes. Then we use modifications of the mazes to first demonstrate a learning paradigm that worms can memorize the location of a darkened surrounding through training. However, a memory formation failure was found that in the situation of providing identical shapes in a maze, planarians cannot memorize the location of the darkened surrounding. Thus, this result shows the planarians associated darkness with the crude shape of the objects they’ve crawled, which is a kind of spatial learning. This finding not only provides a key insight into spatial learning information that planarians are processing, but also an interpretation of the origin of memory formation where higher grades of memory formation might originate from.
Clinical characteristics of late recurrence in granulosa cell tumor of ovary
Authors: Zheng Yawen , Gu Ying , Zhang Wenjin , Yang Xingsheng , Dong Ruiying 
Published: May 2021

Abstract
Objective: To explore the clinical features and treatment of 22 patients with recurrent ovarian granulosa cell tumor (GCT). Methods: The clinical data of 22 females with recurrent ovarian GCT and received treatments in Qilu hospital were retrospectively analyzed. Results: During the recurrence interval, late recurrence (≥5 years) appeared in 14 patients, early recurrence (<5 years) were in 8 patients. Among the 22 recurrent patients, 8 cases had second relapses during the time of follow-up. Of the 14 late recurrent cases, 10 cases had FIGO stage Ⅰ cancers, 4 had stage Ⅲ cancers. Among the 8 early recurrent GCT cases, 5 had FIGO stage Ⅰ cancers. FIGO stage and whether performed fertility-sparing surgery or not had significant impacts on the recurrence type (P =0.035 and 0.016, respectively). Conclusions: The intervals of GCT recurrence are usually long after the initial diagnosis. Continuous long-term follow-up is absolutely required, especially for those with early stage and complete surgery.
Use of a Feedback Device in Simulated Cardiopulmonary Arrest can improve cardiopulmonary resuscitation better than training
Authors: Zeng Rong , Liu Daoquan , Ma Haoli , Lin Lian , Zhou Xianlong , Zhao Yan , Jin Xiaoqing 
Published: May 2021

Abstract
Background:High-quality cardiopulmonary resuscitation (CPR) is the basis of successful cardiac arrest resuscitation, but the bystanders often perform inadequate compressions.Objective:To determine whether the use of an audiovisual feedback (AVF) device during cardiopulmonary resuscitation(CPR) training or a simulated cardiopulmonary arrest (CPA) scenario is more conducive to improving the quality of chest compression (CC).Methods:A total of 160 participants from Wuhan University and senior clinical medicine undergraduates who had not participated in any CPR training before and had no actual CPR experience were recruited.They were randomly divided into the following 4 groups.First,all participants practiced on the Resusci Anne QCPR manikin during CPR training. All participants practiced at least 3 cycles of CC each time (Group C and Group D received the AVF device) until they passed the assessment. Finally, they took part in a 2-minute continuous CC during simulated CPA (Group B and Group D received the AVF device)Results:CC quality was improved with the AVF device during simulated CPA. With the AVF device compared with no AVF device improved depth compliance during simulated CPA by 22.8% (P<0.001) and rate compliance by 11.3% (P=0.003). The use of the AVF device during CPR training resulted in a –2.6% (P =0.61) change in appropriate CC depth compliance compared with no AVF device. At the same time, there was a –1.3% (P = 0.724) change in compliance with rate guidelinesConclusion:Use of a feedback device in simulated cardiopulmonary arrest can improve cardiopulmonary resuscitation better than training.