bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the clathrate complex of selenopyran and β-cyclodextrin on the rate of healing of a conditionally aseptic full-thickness planar wound in rats
Authors: Zayats D. V. , Buyklinskaya O. V. , Fedotova Ju. R. , Felenko N. S. 
Published: December 2021

Introduction. Selenopyran is an organic selenium compound with sharply hydrophobic properties. An increase in solubility in water (and as a consequence – and bioavailability) is possible due to the formation of inclusion complexes with cyclodextrins.Aim. The aim of this work was to study the effect of a gel containing a clathrate complex of selenopyran with β-cyclodextrin on the rate of wound healing on a model of a conditionally aseptic full-thickness planar wound in rats.Materials and methods. The object of the study was a gel containing a clathrate complex of selenopyran with β-cyclodextrin (the content of selenopyran in the gel was 0.1 %). A model of a full-thickness planar wound in sexually mature male rats was used. 20 individuals were divided into 2 groups – intact (without treatment) and experimental (received gel treatment). Efficacy was assessed by the change in wound area at 3, 5, 7, 9, 11 and 14 days after application of wound.Results and discussion. The results of the study showed that the relative area of the wounds in the treated animals by the 3rd day of the experiment was less than in the intact ones. On the fifth day of the experiment, the differences were statistically significant (57.49 ± 12.51 % in treated animals versus 85.27 ± 26.61 % in intact animals). By the 14th day of the experiment, there were practically no differences in the groups of animals.Conclusion. The results obtained indicate that when using a gel containing selenopyran in combination with β-cyclodextrin, it accelerates the transition from the inflammation phase to the proliferation phase. This is most likely due to the antioxidant properties of selenopyran. Considering the lower concentration of selenopyran in comparison with the therapeutic concentrations of other antioxidants (taurine, allantoin), it can be considered as a promising wound healing agent for further study.
Laboratory diagnosis of the Tropicamide non-drug consumption
Authors: Strelova O. Yu. , Slustovskaya Yu. V. , Grebenyuk A. N. 
Published: December 2021

Introduction. Lately, medical services have reported a lot of cases caused by taking Tropicamide alone or with other drugs together. Moreover, it has been declared that the increase in the number of resistance cases to Tropicamide consumption has. Due to those facts, Tropicamide was included in the List of Drugs for Medical Use that should be served by the prescriptions in 2015. However, nowadays in Russia there are many combinations of medicines, for instance, Tropicamide and α-adrenergic agonist (phenylephrine) (Midrimax, Fenikamid, Appamide plus) that are not under that regulation. As a result, those medicines are served in pharmacies without any prescriptions. Thus, method developing for Tropicamide determination in the hair samples to establish his consumption period has become a perspective one.Aim. The research aimed to develop a method for the isolation and determination of Tropicamide in the hair samples.Materials and method. Reference standard of Tropicamide was used in this research. The following enzymes – papain, chymopsin, chymotrypsin, and hyaluronidase – were applied in the experiment. To design the long-term consumption of Tropicamide, laboratory animals (Guinea pigs, average masses about 200 – 250 g) with fair and brown nature colour hair were used in this research. The hair of laboratory animals was dyed by professional hair-dye "Estel Professional De Luxe". The following equipment was applied: balance "Sartorius СР224S", pH-meter " FiveEasy ", ball mill Retsch MM-200. The hair samples extracts were analyzed by gas chromatography with mass selective detection (Gas chromatograph model 7890А with mass selective detector model 5977 and MassHunter GC/MS software by Agilent Technologies).Results and discussion. All developed methods of enzymatic hydrolysis (by papain, chymopsin, chymotrypsin, and hyaluronidase) revealed comparable results for the Tropicamide determination in the hair samples. The research showed that the amount of the analyte isolated from the pigmented hair was a bit higher in comparison with the other hair samples (fair hair), despite the melanin gives chemical steadiness property to hair stuff. Moreover, the amount of Tropicamide extracted from the dyed hair samples increased by 30 %. The degradation products of the analyte of interest were not found in the extracts obtained for the dyed hair samples. Thus, the colorant does not destroy the xenobiotic during the hair dying procedure and does not impact the enzymatic hydrolysis process. The values of the validation parameters (precision and accuracy) met the required criteria for bioanalytical methods. Therefore, the enzymatic hydrolysis method can be recommended for application in laboratory practice.Conclusion. In the course of the study, a method for laboratory diagnostics of non-drug use of tropicamide was developed, the reproducibility of which meets the acceptance criteria for bioanalytical methods, which makes it possible to recommend it for work in laboratory practice.
Comparative GC-MS analysis of the composition of metabolites of aboveground and underground parts of Comarum palustre L
Authors: Strugar J. , Orlova A. A. , Povydysh M. N. 
Published: December 2021

Introduction. Understanding the mechanisms of accumulation of individual groups of biologically active substances in promising types of plant raw materials and the possibility of predicting them is important for solving fundamental and applied problems of pharmaceuticals. To date, differences have been revealed in the qualitative and quantitative composition of secondary metabolites in the aboveground and underground of Comarum palustre L., however, the issue remains unstudied.Aim. Comparative metabolomic study of the composition of the primary metabolites of the aboveground and underground parts of Comarum palustre L.Materials and methods. The object of the study was the aboveground and underground parts of Comarum palustre L., harvested in the vicinity of the nursery of medicinal plants of the St. Petersburg State Chemical and Pharmaceutical University (Leningrad Region, Vsevolozhsky District, Priozerskoe Highway, 38 km) in 2019 and dried. Metabolomic studies based on GC-MS method was perfomed. A statistical analysis based on the MetaboAnalyst 5.0 platform was used.Results and discussion. Analysis of the chromatograms obtained using the GC-MS method revealed the content of 933 primary metabolites in the aboveground and underground parts of Comarum palustre L., 120 of which were identified. Using a number of statistical methods, 10 metabolites from monosaccharides, acids and alcohols, making the greatest contribution to the manifestation of differences between the studied samples, were identified.Conclusion. The study revealed the relationship between the composition of primary and secondary metabolites in medicinal plant raw materials.
Tafsir Ayat-Ayat Kekerasan Seksual: Analisis Metodologis Terhadap Penafsiran Kongres Ulama Perempuan Indonesia (KUPI)
Authors: Muflihah Anisa , Mursyid Ali 
Published: December 2021

Data telah menunjukkan bahwa, kasus kekerasan seksual angkanya terus meningkat, termasuk dalam lembaga pendidikan sekalipun. Sementara itu Permendikbud No. 30 tahun 2021 yang bertujuan untuk mencegah dan menangani kekerasan seksual di Perguruan Tinggi. Pada tahun 2017, diselenggarakan Kongres Ulama Perempuan Indonesia (KUPI), yang di antaranya membahas tentang kekerasaan seksual. Penafsiran ayat-ayat kekerasan seksual dalam perspektif KUPI di antaranya menyatakan dua hal: Pertama, kekerasan seksual baik dilakukan di luar perkawinan maupun di dalam perkawinan, hukumnya haram. Kedua, perkosaan dan perzinahan, meski sama-sama hubungan seksual yang dilarang Islam, namun keduanya berbeda. Perkosaan adalah hirâbah di mana pelaku memaksa korban untuk berhubungan seksual, dalam hal ini pelaku dan korban berbeda. Pelaku melakukan dua tindakan terlarang sekaligus yakni perzinahan dan pemaksaan. Sementara korban tidak melakukan kesalahan karena dipaksa, sehingga korban kekerasan seksual tidak boleh disamakan dengan kasus perzinahan, dan seharusya korban kekerasan seksual diberikan konpensasi. Inilah di antara hasil Kongres Ulama Perempuan Indonesia (KUPI) yang tertulis dalam Dokumen KUPI. Adapun dalam menganalisa digunakan pisau analisa Ilmu Tafsir, yang menganlisa sumber penafsiran, paradigma dan prinsip penafsiran, metode tafsir dan corak penafsiran. Dari hasil analisa tersebut, tentang metodologi penafsiran KUPI terkait ayat-ayat kekerasan seksual adalah: pertama, sumber penafsiran pada KUPI adalah campuran, menafsirkan dengan sumber bi al-ma‟tsûr dan menafsirkan dengan sumber bi alra‟yi. Sumber bi al-ma‟tsûr-nya menafsirkan Al-Qur‟an dengan AlQur‟an dan Al-Qur‟an dengan Sunnah/Hadits. Dalam hal ini KUPI menggunakan munâsabah antar ayat dengan ayat lainnya, antar ayat dengan hadis. Sedangkan sumber bi al-ra‟yi-nya itu dengan merujuk padangan-pandangan para ulama ahli fiqih. Kedua, prinsip-prinsip penafsiran KUPI adalah prinsip kemanusiaan, keadilan, kesetaraan, ketersalingan, kebaikan, kemaslahatan, kebangsaan, dan keadilan gender. Ketiga, metode Penafsiran KUPI menggunakan metode maudhu`i dengan pendekatan teori mubadalah. Keempat, corak penafsiran KUPI menggunakan corak fiqih, karena memang pembahsan penafsiran ayat yang dilakukan, kemudian berujung pada penetapan hukum Islam. Selain itu juga karena pandangan ulama-ulama tafsir yang dirujuk juga kebanyakan adalah mufassir dan para ahli fiqih.
The concept of real losses as a component of the concept of losses in the sphere of intellectual property: category of law and economics
Authors: Shulpin Ihor 
Published: December 2021

Keywords: real losses, intellectual property rights, object of intellectual propertyrights, subject of intellectual property rights, right to own, use and dispose of intellectualproperty rights, contractual obligations, non-contractual legal relations
This article provides an analysis and formulation of the category of «real losses» in thefield of intellectual property. The categories of «real losses» in relation to the propertysphere and the sphere of intellectual property are analysed and justified.First, the author will consider the concept of «real losses» in the property sphere,which was previously studied by many well-known legal scholars and lawyers. Further,we are talking about the structure and Element-by-Element composition of reallosses. Then, the concept of incurred and future expenses is considered.The author notes that everything that concerns the property sphere will also applyto the sphere of intellectual property to a certain extent, but a significant differencewill be that real losses in these areas apply to different subjects, objects and rights. After that, the author will try to provide and analyse the definition of the concept of«real losses» for regarding the sphere of intellectual property.Further, the author focuses on the concept of intellectual property law, the subjectof intellectual property rights, intellectual property rights, objects of intellectualproperty rights under the Civil Code of Ukraine. Also, the article deals with such conceptsas the rights of the owner of rights: the right to own, the right to use and theright to dispose. Further, we are talking about real expenses in the field of intellectualproperty.Summing up the theoretical material presented above and taking into account thechanges of the author that he proposed, the definition of the concept of "real losses" inthe field of intellectual property is given.According to the author, such a legal norm could be included in the fourth book«Intellectual Property Law», Chapter 35 «general provisions on intellectual propertylaw» of the Civil Code of Ukraine, in the article on losses.
Role of intellectual property as key element of innovation activities: legal grounds
Authors: Yarmoliuk Anastasiia 
Published: December 2021

Keywords: intellectual property, intellectual property rights, innovation activities,innovation activity companies (entities), open innovations concept, open innovationplatforms
The article determinates that, on the background of a digitaleconomics actively development, the open innovations become a key source of digitalbreakthrough. The author states that within such a concept, the entities carryinginnovation activity, keep focus on monetizing both the internal research results aswell as the external ideas. Such approach, enhanced with external partners involvementinto the innovations process, helps the innovative technologies to move remarkablyfaster through the lifecycle. It is also emphasized that the approach enabling externalaccess to the companies’ innovations, need a concept to be set up, with focus onintellectual property rights protection. The author draws attention that the key roleof legal instruments for intellectual property protection, is to minimize the risk forthose companies which contribute to the innovations market development. It is clarifiedthat within such a concept, the innovation activity companies provide their partnersthe right to use the intellectual assets, which may be either already in use bysuch companies or idle to use. Thus, the companies providing legal protection of theintellectual property, have more favourite conditions to come into a strategic partnership.The author highlights that the innovations-industry companies make profitfrom getting access to science-research and related production outputs which areowned by their partners, as well as from further development of their own productsresulting from the intellectual property under the strategic agreement. The articlealso proposes creation of digital platforms which will facilitate the effective partnershipof the business, state organizations and innovation teams within the developmentprocess of innovation products.
Satisfacción de la atención en el servicio de emergencia de una institución privada de salud
Authors: Matzumura Kasano Juan , Gutiérrez Crespo Hugo , Zamudio Eslava Luisa 
Published: December 2021

La satisfacción del paciente es uno de los objetivos más importantes de cualquier sistema de salud. El objetivo de este estudio plantea describir la satisfacción de la atención en el servicio de emergencia de una institución privada de salud de categoría III-1. Para ello se realizó un estudio descriptivo de corte transversal. La población de estudio estuvo conformada por los pacientes y/o acompañantes con una muestra constituida por 206 participantes. El instrumento utilizado fue tomado de la Guía Técnica para la Evaluación de la Satisfacción del Usuario Externo, aprobada por el Ministerio de Salud del Perú, que consta de dos componentes: percepciones y expectativa, con 22 preguntas cada uno. Los resultados mostraron que la edad media de los pacientes fue de 51,8 años con predominio del sexo femenino. Así mismo, en la dimensión fiabilidad, la insatisfacción fue 57,4 %; en la dimensión capacidad de respuesta, se encontró 63 % de insatisfacción; la dimensión seguridad, 56,9 % de insatisfacción, las dimensiones empatía y aspectos tangibles, obtuvieron un 55.6% de insatisfacción. Se concluye que la dimensión capacidad de respuesta obtuvo la mayor puntuación de insatisfacción, mientras que la dimensión empatía y aspectos tangibles obtuvieron mejores resultados de satisfacción. La puntuación final fue 42,4 % de satisfacción.

Palabras Clave: Satisfacción, emergencia, paciente, atención

Abstract
Patient satisfaction is one of the most important objectives of any health system. The objective of this study is proposed to describe the satisfaction of the attention in the emergency service of a private health institution of category III-1. For this purpose, it was realized a cross-sectional descriptive study was carried out, the study population was made up of the patients and/or companions, the sample consisted of 206 participants. The instrument used was taken from the Technical Guide for the Evaluation of External User Satisfaction approved by the Ministry of Health, which consists of two components; perceptions and expectation, with 22 questions each. The results showed that patients’ average age was 51.8 years with a predominance of females. Likewise, in the reliability dimension, the dissatisfaction was 57.4 %; in the response capacity dimension, it was 63 % of dissatisfaction; the safety dimension, 56.9 % of dissatisfaction, and the dimensions of empathy and tangible aspects was 55.6 % of dissatisfaction. It is concluded that the response capacity dimension obtained the highest dissatisfaction score; while the empathy dimension and tangible aspects obtained better satisfaction results. The final score was 42.4 % satisfaction.

Keywords: Satisfaction, emergency, patient, attention
Evolución de la mortalidad por cáncer gástrico en el adulto mayor Cuba 1987-2015
Authors: Gámez Sánchez Donelia , Dueñas Moreira Odeite , Saguet Karen Alfonso , Varona Pérez Patricia , Pérez Jiménez Dianellys , Corona Miranda Beatriz 
Published: December 2021

El cáncer gástrico afecta principalmente a las personas de edad avanzada. Con el objetivo de caracterizar la evolución de la mortalidad por cáncer gástrico en el adulto mayor en Cuba durante los años 1987-2015, según variables sociodemográficas seleccionadas, se realizó un estudio ecológico de series temporales. El universo estuvo conformado por 16713 fallecidos mayores de 60 años en Cuba, cuya causa de muerte registrada en el certificado de defunción fue el cáncer gástrico. Se analizaron tasas anuales crudas y ajustadas por grupos de edad y sexo. Predominó el sexo masculino con 62,3 % y el grupo de edad de 70-79 años con 37,1 %, mayor frecuencia de morir en hombre 1,6:1. El 38,6 % de los fallecidos tenía color de la piel blanca, más frecuente en el sexo masculino. Fue evidente que a la hora de la muerte predominó la condición de fallecidos sin parejas estables en 57,4 %. Las tasas de mortalidad ajustadas por grupos de edad aumentan después de la octava década de la vida. La evolución de la mortalidad por cáncer gástrico durante los últimos 28 años muestra una tendencia ascendente a predominio del sexo masculino, se hace necesario diseñar e implementar programas de detección precoz que vayan dirigidos a la disminución de la mortalidad en los adultos mayores.

Palabras clave: Cáncer gástrico, adulto mayor, tasa de mortalidad, tasa bruta de mortalidad y tasa ajustada de mortalidad.

Abstract

Gastric cancer affects mainly the elderly. Objective: to characterize the evolution of mortality due to gastric cancer in the elderly. Cuba 1987-2015 according to selected sociodemographic variables. Method: ecological study of time series. Universe: 16713 deaths in the country over 60 years whose basic cause of death recorded in the death certificate was gastric cancer. Crude annual rates adjusted for age and sex groups were analyzed. Results: male sex predominated with 62.3 % and the age group of 70-79 years with 37.1 %, higher frequency of death in male 1.6: 1. 38.6 % of the deceased had white skin color, more frequent in the male sex. It was evident that at the time of death the condition of deceased without stable partners predominated in 57.4 %. Mortality rates adjusted for age groups increase after the eighth decade of life. Conclusion: the evolution of mortality from gastric cancer during the last 28 years shows an ascending tendency to predominance of the male sex, it is necessary to design and implement early detection programs that are aimed at reducing mortality in the elderly.

Keywords: Gastric cancer, older adult, mortality rate, crude and adjusted rates.
Fiebre reumática, errores diagnósticos comunes y retraso del tratamiento: a propósito de un caso
Authors: Moreira Vera Diana Victoria , Cedeño Vélez David Ramón , Mendoza Guillem Egny María 
Published: December 2021

La fiebre reumática es la secuela más común por amigdalitis debida al estreptococo β-hemolítico del grupo A, siendo la causa más frecuente de valvulopatía adquirida en niños. Se presenta el caso de una niña de 10 años de edad que acudió a emergencias debido a artralgia en rodillas, piernas y tobillos, de ocho días de evolución alternando su intensidad 48 horas en cada articulación y fiebre de 39ºC. Antecedentes de faringoamigdalitis a repetición desde los dos años con sugerencia de amigdalectomía. Se observaron valores de antiestreptolisina positivos. Se encontró artritis como criterio mayor y la fiebre junto con los valores de la antiestreptolisina como criterios menores, además de los antecedentes de amigdalitis a repetición. Su relevancia recae en el abordaje variado que recibió la paciente y la duda diagnóstica de la enfermedad.

Palabras clave: Fiebre reumática, poliartritis, faringitis, criterios de Jones.

Abstract
Rheumatic fever is the most common sequel due to tonsillitis caused by the group A β-hemolytic streptococci, being the most frequent reason of acquired valvulopathy in children. The case of a 10-year-old girl who went to the emergency room due to arthralgia in the knees, legs and ankles of eight days of evolution - alternating its intensity 48 hours in each joint - and fever of 39 ºC is presented. History of pharyngotonsillitis repeated since two years-old with suggestion of tonsillectomy. Anti streptolysin values were positive. Arthritis was found as major criterion and fever along with anti streptolysin values as minor criteria, in addition to the history of recurrent tonsillitis. Its relevance lies in the varied approach that the patient received and the diagnostic doubt of the disease.

Keywords: Rheumatic fever, polyarthritis, pharyngitis, Jones criteria.
Susceptibilidad antimicrobiana de cepas aisladas de muestras clínicas en el laboratorio del Hospital General Dr. Liborio Panchana Sotomayor
Authors: Suárez González Patricia 
Published: December 2021

La causa principal de la resistencia es el abuso de los antimicrobianos. El objetivo de este estudio fue determinar la resistencia antimicrobiana en aislamientos bacterianos de muestras biológicas de pacientes que acuden al hospital de Santa Elena (Ecuador) en 2017. Se efectuó un estudio retrospectivo correspondiente a los principales agentes infecciosos aislados de muestras de pacientes del área de la Península de Santa Elena. Las cepas aisladas fueron analizadas por el método difusión Kirby-Bauer. Escherichia coli se destacó como principal agente causal, seguida por Klebsiella spp. Se aislaron en mayor proporción de infecciones del tracto urinario tanto en pacientes hospitalarios como la comunidad. En el caso de los aislamientos de Pseudomonas aeruginosa provinieron de exudados óticos en pacientes ambulatorios, mientras que en pacientes hospitalizados se aislaron de muestras de aspirados traqueales. Staphylococcus aureus fue identificado en muestras de hemocultivo.

Palabras clave: Escherichia coli, sensibilidad, antibióticos, betalactamasas.

Abstract
The main cause of resistance is the abuse of antimicrobials. The objective of this study was to determine the antimicrobial resistance in bacterial isolates from biological samples of patients who attended the Santa Elena hospital (Ecuador) in 2017. A retrospective study was carried out corresponding to the main infectious agents isolated from samples of patients in the area of the Santa Elena Peninsula. The isolated strains were analyzed by the Kirby-Bauer diffusion method. Escherichia coli stood out as the main causative agent, followed by Klebsiella spp. They were isolated in a higher proportion of urinary tract infections both in hospital patients and in the community. In the case of Pseudomonas aeruginosa isolates, they came from otic exudates in outpatients, while in hospitalized patients they were isolated from tracheal aspirate samples. Staphylococcus aureus was identified in blood culture samples.

Keywords: Escherichia coli, sensitivity, antibiotics, beta-lactamases.