bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of immunodiagnostics in dynamic observation of tuberculosis treatment in children
Authors: Romanova M. A. , Mordyk A. V. , Kurieva K. B. , Churyak K. I. 
Published: August 2021

The use of recombinant tuberculosis allergen (ATR) expands the possibilities of detecting tuberculosis. Nevertheless, the issue of the predictive value of the ATR test for assessing the result of tuberculosis therapy remains insufficiently studied.Purpose.Тo clarify the information content of changes in the results of a test with a recombinant tuberculosis allergen against the background of chemotherapy for tuberculosis in children.Materials and methods. We used the data of patients with active tuberculosis aged 0 to 14 years who were hospitalized. The main group in the study (1st) included 280 children with a pronounced reaction to ATR, the comparison group (2nd) consisted of 42 children with a moderate, mild and doubtful reaction to ATP at the time of tuberculosis detection.Results.After 6 months from the beginning of the intensive phase of tuberculosis treatment, a hyperergic reaction to the administration of ATR was diagnosed in 74 (38.7%) children of the 1stgroup and 4 (16.7%) children of the 2nd group (p = 0.025). A twofold decrease in the sample size was observed in children of the 1st group (121 children – 63.4%) than the 2nd(7 children – 29.2%) (χ2 = 8.97, p = 0.003; OR = 4.198; 95% CI 1.66–10.62). The increase in the sample is 2.9 times higher in children of the 2nd group (44 children – 23%) than in children of the 1st (χ2 = 20.17, p = 0.000).Conclusions.The extinction of sensitivity to the ATR test after specific therapy is 2 times higher in children who initially had a pronounced reaction. In the same group, a hyperergic reaction to the sample often persists or occurs after the intensive phase of anti-tuberculosis therapy.
Study on the Effects of Kuanxiong Aerosol on the Isolated Artery and
Rabbits Acute Myocardial Ischemia Model
Authors: Zhu Wanping , Liu Xia , Huang Feihua , Lu Xiao , Wang Yuji , Cai Tingting , Peng Aiping 
Published: August 2021

Background:
Kuan Xiong aerosol (KXA) is a Chinese herbal compound used to regulate
qi-flowing to relieve pain and improve angina. However, only a few pharmacological studies
on this traditional Chinese medicine preparation have been reported to confirm these activities.

Objective:
This article aims to observe the effect of resisting acute myocardial ischemia (AMI) in
vivo and dilating vessel in vitro of KXA.

Materials:
The AMI model involves intravenously injecting pituitary (2 U.kg-1) into the ear of rabbits. Electrocardiograph (ECG) T waves were then recorded after administration and the falling range was calculated. Following this, the level of serum Cardiac troponin T (cTn-T) and the histopathology of the cardiac muscle tissue was evaluated. In vitro, the effect of KXA on vasodilation of isolated aortic rings that had been pre-contracted with KCl (30 mM) was observed.

Results:
The AMI model involves intravenously injecting the pituitary (2 U.kg-1) into the ear of
rabbits. Electrocardiograph (ECG) T waves were then recorded after administration, and the falling
range was calculated. Following this, the level of serum Cardiac troponin T (cTn-T) and the histopathology
of the cardiac muscle tissue were evaluated. In vitro, the effect of KXA on vasodilation
of isolated aortic rings that had been pre-contracted with KCl (30 mM) was observed.

Conclusions:
These results suggest that KXA protects against AMI, contributes to the dilation of
blood vessels, and has long-acting effectiveness.
Correlation between Intrapartum Cardiotocogram Findings and Cord
Blood pH in Term and Preterm Labors
Authors: Rao Shubha , Jain Himanshi , Suneel Anjali , Shivananda Roopa Padavagodu , Vasudeva Akhila 
Published: August 2021

Background:
The purpose of intrapartum fetal monitoring by cardiotocograph (CTG) is
to identify early signs of developing hypoxia so that appropriate action can be taken to improve the
perinatal outcome. Although CTG findings are well known to monitor the progress of the labor due
to the paucity of recommendations, there has always been a clinical dilemma as the term fetuses respond
differently than a preterm fetus. However, umbilical cord blood pH can distinguish the infant
at high risk for asphyxia and related sequel. Therefore, because of differences in fetal physiology
in term and preterm fetuses, CTG findings vary, and hence the validity of CTG to determine fetal
acidosis should be different.

Aims and Objectives:
This study aimed to correlate abnormal intrapartum CTG findings with umbilical
cord blood pH in term and preterm labor and thus evaluate the success of CTG in predicting
fetal acidosis during labor.

Methods:
The present study included 210 women in labor (70 preterm and 140 term) with abnormal
intrapartum CTG that was classified as per 2015 revised International Federation of Gynecologists
and Obstetrician (FIGO) guidelines. Immediately after delivery, 2 ml Umbilical artery cord
blood sample was taken in a pre-heparinized syringe for analysis, pH <=7.2 was taken as acidosis
and pH >7.2 was taken as normal. The measured data were general maternal characteristics which
included gravida status, associated comorbidities, method of induction and character of liquor, the
intrapartum CTG tracings recorded, the cord arterial blood pH and the neonatal characteristics such
as APGAR score and neonatal outcome.

Results:
Data from 70 preterm labor was compared with 140 term labor. In this study, 20.9% of the
babies had acidosis. Suspicious CTG due to decreased variability were more common in the
preterm group than in the term group (21.4% vs. 8.6% p<0.05). Positive predictive value (PPV) of
abnormal CTG for fetal acidosis in the preterm group was found to be higher than that in the term
group, PPV of pathological CTG being even higher than suspicious CTG. Women with suspicious
CTG had 82% less risk of fetal acidosis as compared to pathological CTG. Women with Bradycardia
had 5.9 times the risk of fetal acidosis as compared with normal and tachycardia.

Conclusion:
Abnormal CTG should be managed appropriately without any delay to prevent acidosis
and cord blood pH should be done in all labors with abnormal CTG. However, our findings of a
higher incidence of lower cord blood pH and suspicious CTG due to decreased variability alone
highlight the limitation of criteria currently used for interpretation of CTG in preterm labors.
SDF-1 Molecularly Imprinted Biomimetic Scaffold as a Potential Strategy to Repair the Infarcted Myocardium
Authors: Rosellini Elisabetta , Madeddu Denise , Barbani Niccoletta , Frati Caterina , Lagrasta Costanza , Quaini Federico , Cascone Maria Grazia 
Published: August 2021

Background:
In situ cardiac tissue engineering aims to heal the infarcted myocardium by guiding tissue regeneration within the patient body. A key step in this approach is the design of a bioactive scaffold, able to stimulate tissue repair at the site of damage.
In the development of bioactive scaffolds, molecular imprinting nanotechnology has been recently proposed as a new functionalization strategy.

Objectives:
In this work, Molecularly Imprinted Particles (MIP) with recognition properties towards the stromal-derived factor-1 (SDF-1) were synthesized, characterized and used for the functionalization of a biomimetic scaffold. MIP are expected to favor the enrichment of the SDF-1 bioactive molecule within the scaffold, thereby promoting myocardial regeneration.

Methods:
MIP were obtained by precipitation polymerization, using the SDF-1 molecule as a template. Alginate/gelatin/elastin sponges were fabricated by freeze-drying and functionalized by MIP deposition. Morphological, physicochemical and functional analyses were performed both on MIP and on MIP-modified scaffolds. A preliminary biological in vitro investigation was also carried out using rat cardiac progenitor cells (rCPCs).

Results:
Imprinted nanoparticles with an average diameter between 0.6 and 0.9 µm were obtained. Infrared analysis of MIP confirmed the expected chemical structure. Recognition and selectivity tests showed that MIP were able to selectively recognize and rebind the template, even after their deposition on the scaffold. In vitro biological tests showed that cell adhesion to the scaffold was promoted by MIP functionalization.

Conclusion:
Results obtained in the present study suggest that biomimetic alginate/gelatin/elastin sponges, functionalized by MIP with recognition properties towards SDF-1, could be successfully used for tissue engineering approaches to repair the infarcted heart.
Epidemiology of Orbital Fractures in a Large Hospital in the Netherlands: Results of Implementation of a Multidisciplinary Orbital Trauma Team
Authors: Kooger Tamar J. A. , Joosse Maurits V. , van Minderhout Ellen M. , Hergaarden Kenneth , Khouw Yu-Lan 
Published: August 2021

Introduction:
This study aims to describe the epidemiology, aetiology and therapy of orbital fractures in a large municipal hospital in The Hague, the Netherlands, and to demonstrate the effectiveness of an integrated approach of orbital trauma care with a team consisting of an ophthalmologist, an orthoptist and an oral and maxillofacial (OMF) surgeon.

Methods:
We obtained data from patients with an orbital fracture between June 2015 until July 2018. Primary outcomes were the classification of orbital fractures and treatment (conservative or surgical).

Results:
182 patients were included in this study. The most common type of orbital fracture was an isolated orbital floor fracture (n=56, 30.8%). In most cases, therapy was conservative (69.2%). When surgical repair was indicated, a polydioxanone (PDS) plate was most commonly used (11.5%). The main cause of an orbital fracture was a fall accident (38.5%), followed by assault (32.4%). 32.4% of the patients were intoxicated with alcohol.

Conclusion:
In our study population, almost 70% (69.2%) of the patients were treated conservatively in our study. Compared to the international literature, this percentage is considerably higher than in other studies. In our opinion, our integrated approach to orbital trauma has led to a justifiable reduction of the proportion of cases receiving surgical intervention in orbital fractures. We would like to advocate the implementation of a similar team in other hospitals to improve the quality and cost-effectiveness of treatment in patients with orbital fractures.
The Therapeutic Effect and Mechanism of Qishen Yiqi Dripping Pills on
Cardiovascular and Cerebrovascular Diseases and Diabetic Complications
Authors: Zhao Chunlai , Wang Wenjia , Yan Kaijing , Sun He , Han Jihong , Hu Yunhui 
Published: August 2021

Abstract:
The alterations in vascular homeostasis are deeply involved in the development of numerous
diseases, such as coronary heart disease, stroke, and diabetic complications. Changes in
blood flow and endothelial permeability caused by vascular dysfunction are the common mechanisms
for these three types of diseases. The disorders of glucose and lipid metabolism can bring
changes in the energy production patterns in endothelium and surrounding cells which may consequently
cause energy metabolic disorders, oxidative stress, and inflammatory responses. Traditional
Chinese medicine (TCM) follows the principle of the “treatment by the syndrome differentiation.”
TCM considers coronary heart disease, stroke, and diabetes complications all as the type of
Qi-deficiency and blood stasis syndrome, which mainly occurs in the vascular system. Therefore,
the common pathogenesis of these three types of diseases suggests that the treatment strategy by
TCM should be in a close manner and referred to as “treating different diseases by the same treatment.”
Qishen Yiqi dripping pill is a modern Chinese herbal medicine that has been widely used
for the treatment of patients with coronary heart disease characterized as Qi-deficiency and blood
stasis in China. Recently, many clinical reports have demonstrated the potential therapeutic effects
of Qishen Yiqi dripping pills on ischemic stroke and diabetic nephropathy. Based on these reports,
we will summarize the clinical applications of Qishen Yiqi dripping pills on coronary heart disease,
ischemic stroke, and diabetic nephropathy, including the involved mechanisms discussed in
various research works.
The Quality of Family Interpersonal Communication during COVID-19
Authors: Ades Andaleep 
Published: August 2021

Background:
The occurrence of the COVID-19 pandemic has significantly impacted the general lifestyle of people across the globe, especially with the new safety directives, which have affected people’s interactions in many different ways.

Objective:
The aim of the study was to examine the quality of interpersonal communication among family members during COVID-19 restrictions in Saudi Arabia. The study objective was achieved through investigating the three main questions: How is the pandemic influencing the connection and communication between the family members? How do the family members stay connected during the COVID-19 restrictions in Saudi Arabia? And lastly, what type of social media platforms are families using to stay connected with each other?

Methodology:
The present research used a Google survey form as a tool to receive responses from 400 participants in Saudi Arabia.

Results
The results have shown that COVID-19 has greatly affected people's interactions, including family interpersonal communication. Families have
been forced to adapt modern forms of communication rather than indulging in normal face-to-face interactions, as various governments across the
world encourage virtual communication.

Conclusion:
IMO has become very popular among various family members; however, some other applications have also been used to stay connected with the family, like Twitter, Facebook, and WhatsApp.
A Numerical Study for Determining the Effect of Raffia, Alfa and Sisal Fibers on the Fiber-matrix Interface Damage of Biocomposite Materials
Authors: Achour Bouchra , Mokaddem Allel , Doumi Bendouma , Ziadi Abdelkader , Belarbi Lahcen , Boutaous Ahmed 
Published: August 2021

Background:
Nowadays, natural fibers are used in all industrial fields, particularly in
automotive technology and civil engineering. This great emergence is due to their biodegradability,
recyclability and have no environmental effect.

Objective:
In this article, the effect of raffia, alfa and sisal fibers on the damage of biocomposite
materials (raffia/PLA (polylactic acid), alfa/PLA and sisal/PLA), subjected to the same mechanical
shear stress, has been investigated.

Method:
To calculate the damage to the interface, the genetic operator crossing is employed
based on the fiber and matrix damage.

Result:
The results have shown that the raffia / PLA and alfa/PLA biocomposite materials are
better mechanical properties compared to sisal / PLA, this observation has been confirmed by different
values of interface damage of the biocomposite studied.

Conclusion:
The numerical results are similar and coincide perfectly with the results of Cox
where he demonstrated that the Young's modulus of fibers improves the resistance of the interface.
These conclusions are in very good agreement with our numerical data presented by the red
cloud, and in good agreement with the work presented by Antoine Le Duigou et al. and Bodros et
al. in which they have shown that natural fibers greatly improve the physical characteristics of
composite materials.
Program mindful parenting untuk menurunkan kecemasan pada caregiver anak berkebutuhan khusus
Authors: Sari Dian Sartika 
Published: August 2021

Abstrak : Sebagai pengasuh anak berkebutuhan khusus berhubungan dengan munculnya permasalah fisik dan psikologis pada caregiver. Hal ini memunculkan adanya gejala gejala kecamasan yang tinggi. Intervensi dengan berbasis mindfulness terbukti dapat membantu memberikan ketenangan dan meningkatkan kebahagiaan. Penelitian ini bertujuan untuk menguji pengaruh program mindfulness parenting untuk menurunkan kecemasan pada caregiver anak berkebutuhan khusus. Penelitian ini menggunakan one group pre test dan post test design. Pengukuran kecemasan diukur dengan menggunakan Beck Anxiety Inventory (BAI). Program Mindfulenss parenting terdiri dari 8 sesi program dalam 4 kali pertemuan. Analisis dengan menggunakan uji Wilcoxon rank test menujukkan hasil significant. Hal ini menunjukkan bahwa program mindfulness parenting dapat menurunkan kecemasan pada caregiver anak berkebutuhan khusus Kata Kunci: Mindfulness Parenting. Kecemasan. Caregiver. Anak Berkebutuhan Khusus Mindfulness Parenting program for decreasing anxiety on caregiver who has children with disability Abstract: Caregiver in children with disability related with physically and psychological problem for example the symptoms of anxieties. They have high score in anxiety. Therapy based on mindfulness has evidence helping them in be calmer dan increase happiness. The aim of this study is to examine the effectiveness of “Mindfulness parenting” program in decreasing anxiety on caregiver who has child with disability. This study used a one-group pretest-posttesttt design. “Mindful Parenting” program attended 8 sessions of “Mindful parenting” program in four meetings. Analysis using Wilcoxon signed rank test showed significance result. It conclude that there was significant effect of “Mindfulness parenting” program on decrease anxiety score on caregiver of children with disability. Keywords: Mindfulness Parenting. Anxiety. Caregiver. Children with disability.
MONITORING FEATURES IN UNDERGROUND DEVELOPMENT OF OLD FIELDS
Authors: Бурдзиева О.Г. , Разоренов Ю.И. , Дзеранов Б.В. 
Published: August 2021

Систематизированы сведения об управлении геомеханическим состоянием рудовмещающего массива в сложных горно-геологических условиях путем организации системы геомеханического мониторинга его напряженно-деформированного состояния геофизическими методами при подземной разработке скальных месторождений. Дан критический анализ теорий управления состоянием напряженно-деформированных скальных массивов. Приведены сведения о функциях, способах и схеме организации геофизического мониторинга подземных горных работ. Даны результаты использования геофизических методов на предприятиях – аналогах. Дан анализ геомеханических процессов при разработке старых месторождений Северного Кавказа и показаны особенности их разработки. Показано, что геофизический мониторинг добычных процессов позволяет оценивать устойчивость массива при различных условиях. Даны рекомендации по организации геофизического мониторинга при возобновлении добычных работ в зоне погашенного выработанного пространства.
The information on the geomechanical condition management of ore-bearing massif in difficult mining and geological conditions through the organization of geomechanical monitoring system of its stress-strain state using geophysical methods in underground mining of rock deposits is systematized. A critical analysis of the theories of state management of stress-strain rock massive is given. The information about the functions, methods and scheme of organization of geophysical monitoring of underground mining operations. The results of the use of geophysical methods in the companies – analogues are presented. The analysis of the geomechanical processes in the development of old fields of the North Caucasus and the features of their development are given. It is shown that geophysical monitoring of production processes allows to assess the stability of the massive under various conditions. Recommendations on the organization of monitoring with the resumption of mining processes in the area of gotten oaf are given.
DATA OF DEEP GEOPHYSICAL SURVEYS ALONG CHEGEM PROFILE (CENTRAL BLOCK, THE GREATER CAUCASUS)
Authors: Кухмазов С.У. , Чотчаев Х.О. , Шемпелев А.Г. 
Published: August 2021

Геофизические наблюдения вдоль Чегемского профиля (перевал Китлод – г. Буденновск) являются продолжением глубинных исследований структуры Большого Кавказа комплексом геофизических характеристик разреза земной коры в крест всей структуры орогена. На основании фактических материалов МОВЗ, МТЗ и гравимагнитных съёмок выделяются отдельные элементы структуры Большого Кавказа, как части Альпийского коллизионного пояса, очевидно возникшей при пологом надвиге с севера земной коры Скифской плиты на консолидированную кору закавказских микроплит.
Geophysical observations along the chegemsky profile (pass Titled - Budennovsk) are a continuation of the deep studies of the structure of the greater Caucasus the complex geophysical characteristics of the section of the earth crust in the cross the entire structure of the orogen. On the basis of actual materials of the method of exchange waves of earthquakes, the method of telluric current and gravity-filming separate elements of the structure of the greater Caucasus as part of the Alpine collisional belt, obviously occurred when the canopy on thrusting from the North of the earth’s crust of the Scythian plate in the consolidated crust of the Transcaucasian microplate.
BLOCK AND KEY LITHOSPHERIC STRUCTURE OF THE ACTIVE ASIAN NORTH-EASTERN CONTINENTAL MARGIN. KORYAK-KAMCHATKA REGION
Authors: Яроцкий Г.П. 
Published: August 2021

Показана система северо-западных разломов, определивших продольную зональность региональных геоструктур активной окраины Северо-Востока Азии. Они обусловили линейные и гнездовые вулканогены Северо-Западно- и Юго-Восточно-Корякских орогенных поясов и связь с ними рудных районов. Поперечные разломы создают условия субвертикальных движений окраины геоструктур: погружения и воздымания. В килях слоёв прогнутых горизонтов и замках – выгнутых, возникают продольно-осевые разломы – зоны максимальных геодинамических напряжений. На их сочленении с глубинными границами разновозрастных морских террейнов образуются вертикальные сейсмогенные колонны с гипоцентрами сильных (М > 6,6) землетрясений Корякского сейсмичного пояса.
The abstract presents the system of NW faults determining longitudinal zonation of regional geo-structures on the North-East Asia active margin. They defined linear and nested volcanogenic rocks of NW and SE Koryak orogenic belts and their association with ore regions. Transverse faults resulted in possible near-vertical dipping or uplifting of marginal geo-structures. Longitudinal-axial faults are zones of maximum geodynamic stresses arising in troughs of down-horizons’ layers and in curves of convex horizon’s layers. Vertical seismogenic columns with hypocenters of strong (M > 6,6) earthquakes of the Koryak seismic belt are formed on their junction with deep boundaries of multi-aged marine terrains.