bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Do Pregnant Women Experiencing Intimate Partner Violence Expect of Their Health Providers and Hospital Systems?
Authors: Kyei-Onanjiri M , Koziol-McLain J , Spangaro J , Walsh J , Hegarty K 
Published: July 2021

Abstract
Background: Intimate partner violence is a pervasive public health and human rights problem with multidimensional effects on women’s physical, mental and reproductive well-being. The World Health Organization has recommended a first-line response to disclosures of intimate partner violence. However, a strong evidence base of which interventions work best is lacking and there is a greater need to listen to the voices of survivors to tailor responses. The primary purpose of this paper was to explore what pregnant women experiencing IPV wish for from their health providers and hospital systems.Methods: This paper is part of a broader study which included a survey of 1,067 pregnancy care patients at a large tertiary hospital in Melbourne. For this paper, we analysed an open-ended question related to victim/survivor women’s needs and what they wish for from health practitioners and the healthcare system. Overall, while 571 women responded to the open-ended questions, only those relating to women who screened positive on the composite abuse scale or responded ‘Yes’ to screening questions (n = 142) or had been afraid of their partner in the previous 12 months (n = 13) or had experienced reproductive coercion in the last 12 months (n = 6) were analysed for this paper, making a total of 161 respondents. Results: Four main themes emerged from the women in this study: 1) woman-centred care; 2) relationship and domestic violence-specific concerns; 3) male partner involvement and education; and 4) hospital system reform.Conclusions: This study shows that women experiencing intimate partner violence value care that is supportive of them, provides tailored health information, and involves their partner, as well as a health system that is well-organized, accessible and provides continuity of care. It is important to align maternal health services with attributes of care valued by women to meet the complex health needs of pregnant women experiencing intimate partner violence.
Effect of Tai Chi Combined With Kinesio Taping on Posture Control of Football Players With FAI: Protocol For a Randomized Controlled Trial
Authors: LI YH , Li Youhua 
Published: July 2021

Abstract
Background: Functional ankle instability (FAI) of college football players is an important risk factor affecting their training and competition. Physical therapy and appropriate sports intervention can improve the stability of FAI patients. Previous studies have shown that Tai Chi (TC) and Kinesio Taping (KT) can improve the posture control ability of FAI patients. However, whether Tai Chi combined with kinesio taping effect patch can be used as an effective exercise for the rehabilitation of college football players with FAI is not yet proven.Methods/design: 53 FAI college football players were randomly assigned to 3 groups: TC+KT (n=20); TC+KTp (Placebo Kinesio taping, KTp, placebo) (n=17); KT (N=16). The TC+KT group received TC and KT functional correction technical intervention, the TC+KTp group received TC and placebo KT technical intervention, and the KT group received KT functional correction technical intervention. Each of the three groups received 30 minutes each time, 3 times a week, for a total of 6 weeks of intervention training. Star Excursion Balance Test (SEBT) and UniPedal Stance Test (UST) at baseline (before), 4 weeks after intervention (middle) and 6 weeks after intervention (after) , Toe Touch Test (TTT) for evaluation.Discussion: For the first time in this trail, the impact will be evaluated. If the results are the same as expected, they will provide evidence that Tai Chi combined with kinesio taping sticking intervention can promote the posture control of college football players with FAI.。Trial registration: Chinese Clinical Trial Registry, ChiCTR1900027253.Registered on 6 November 2019.
Ki67 Assessment By qRT-PCR In OncotypeDx® Breast Recurrent Score®: Low Correlation With Immunohistochemistry Assessment of Ki67 And Prognostic Impact of Ki67 RNA Level of Expression.
Authors: Selmani Zohair , Molimard Chloé , Overs Alexis , Bazan Fernando , Chaigneau Loic , Dobi Erion , Meneveau Nathalie , Mansi Laura , Paillard Marie-Justine , Meynard Guillaume , Viot Julien , Algros Marie-Paule , Borg Christophe , Feugeas Jean-Paul , Pivot Xavier , Prétet Jean-Luc , Curtit Elsa 
Published: July 2021

Abstract
Breast cancers expressing high levels of Ki67 are associated with poor outcomes. Oncotype DX® test was designed for ER+/HER2- early-stage breast cancers to help adjuvant chemotherapy decision by providing a Recurrent Score® (RS®). RS® measures the expression of 21 specific genes from tumor tissue, including Ki67. The primary aim of this study was to assess the agreement between Ki67RNA obtained with Oncotype DX® RS® and Ki67IHC. Other objectives were to analyze the association between the event free survival (EFS) and the expression level of Ki67RNA; and association between RS® and Ki67RNA.Herein, we report a low agreement of 0.24 by Cohen’s kappa test between Ki67IHC and Ki67RNA in a cohort of 98 patients with early ER+/HER2- breast cancers. Moreover, Ki67RNAhigh tumors were significantly associated with the occurrence of events (p=0.02). On the other hand, we did not find any association between Ki67IHC and EFS (p=0.25).We observed of low agreement between expression level of Ki67RNA and Ki67 protein labelling by IHC. Unlike Ki67IHC and independently of the RS®, Ki67RNA could have a prognostic value. It would be interesting to better assess the prognosis and predictive value of Ki67RNA measured by qRT-PCR. The Ki67RNA in medical routine could be a good support in countries where Oncotype DX® is not accessible.
The Distribution of Giant Manta Rays In The Western North Atlantic Ocean Off The Eastern United States
Authors: Farmer Nicholas A. , Garrison Lance P. , Horn Calusa , Miller Margaret , Gowan Timothy , Kenney Robert D. , Vukovich Michelle , Willmott Julia Robinson , Pate Jessica , Webb D. Harry , Mullican Timothy J. , Stewart Joshua D. , Bassos-Hull Kim , Jones Christian , Adams Delaney , Kajiura Stephen , Waldron Jordan 
Published: July 2021

Abstract
In 2018, the giant manta ray (Manta birostris) was listed as threatened under the U.S. Endangered Species Act. We integrated decades of sightings and survey effort data from multiple sources in a comprehensive species distribution modeling (SDM) framework to evaluate the distribution of giant manta rays off the eastern United States, including the Gulf of Mexico. Manta rays were most commonly detected at productive nearshore and shelf-edge upwelling zones at surface thermal frontal boundaries within a temperature range of approximately 15–30 °C. SDMs predicted high nearshore concentrations off Northeast Florida during April, with the distribution extending northward along the shelf-edge as temperatures warm, leading to higher occurrences north of Cape Hatteras, North Carolina from June to October, and then south of Savannah, Georgia from November to March as temperatures cool. In the Gulf of Mexico, the highest nearshore concentrations were predicted near the Mississippi River delta from April to June and again from October to November. SDM predictions will allow resource managers to more effectively protect manta rays from fisheries bycatch, boat strikes, oil and gas activities, contaminants and pollutants, and other threats.
The Effect of Talus Osteochondral Defects of Different Area Size on Ankle Joint Stability: A Finite Element Analysis
Authors: Li Jia , Wang Yezhou , Wei Yu , Kong Dan , Lin Yuan , Wang Duanyang , Cheng Shi , Yin Pengbin , Wei Min 
Published: July 2021

Abstract
(1) Background: Osteochondral lesion of the talus (OLT) is one of the common ankle injuries, which will lead to biomechanical changes in the ankle joint and ultimately affect the ankle function. The finite element analysis (FEA) was used to clarify the effect of talus osteochondral defects in different depths on the stability of the ankle joint. However, there is no clear research about the area of talus osteochondral defects that should be intervened in time. In this research, FEA is used to simulate the effect of different areas size of talus osteochondral defect on the stress and stability of ankle joint under a certain depth defect.; (2) Methods: The different area size (Normal, 2 mm* 2 mm, 4 mm* 4 mm, 6 mm* 6 mm, 8 mm* 8 mm, 10 mm* 10 mm, 12 mm* 12 mm) of osteochondral defects three-dimensional finite element model was established to simulate and calculate joint stress and displacement of the articular surface of the distal tibia and the proximal talus while the ankle joint was in the push-off phase, midstance phase and heel-strike phase; (3) Results: When OLT occurred, the contact pressure of articular surface, the equivalent stress of the proximal talus, tibial cartilage and talus cartilage did not change significantly with the increase of osteochondral defect area size in heel-strike phase below 6 mm * 6 mm, it increased gradually from 6 mm * 6 mm in midstance phase and push-off phase, and reached the maximum when the defect area size is 12 mm * 12 mm. The talus displacement also has the same tendency.; (4) Conclusions: The effect of cartilage area size defects of the talus on the biomechanics of the ankle is obvious especially in the midstance phase and push-off phase. When the defect size reaches 6 mm * 6 mm, the most obvious change in the stability of the ankle joint occurs, and the effect does not increase linearly with the increase in the depth of the defect.
The Effects of Chemotherapeutic Drugs on PD-L1 Gene Expression in Breast Cancer Cell Lines
Authors: Majidi Misagh , Safaee Sahar , Amini Mohammad , Baghbanzadeh Amir , Hajiasgharzadeh Khalil , Hashemzadeh Shahriar , Shotorbani Siamak Sandoghchian , Mokhtarzadeh Ahad , Baradaran Behzad 
Published: July 2021

Abstract
Breast cancer is the most common cancer among women in terms of prevalence and mortality, and chemotherapy is one of the most effective treatments at higher stages. However, resistance to chemotherapy is the main obstacle in the treatment of this cancer. Accumulated evidence identified the PD-L1 protein as an essential protein in the development of different cancers. Abnormal expression of this protein in various tumor cells is linked to cancer development and inhibiting the function of immune cells, which correlated with reduced beneficial effects of chemotherapy drugs. In the present study, the effects of common chemotherapy drugs including doxorubicin, paclitaxel, and docetaxel on the expression of the PD-L1 gene were investigated by qRT-PCR before and after the treatment with these drugs in MD231, MD468, SKBR3 breast cancer cell lines. Also, the MTT test was applied to examine the effects of drugs on the growth and proliferation of cancer cells considering PD-L1 expression. The expression of the PD-L1 gene increased after 24 and 48 hours of treatment with chemotherapy drugs. The obtained results indicate the enhancing effects of chemotherapy drugs on PD-L1 gene expression, which have a suppressive effect on the immune system against breast cancer. The use of these drugs as the first line of chemotherapy in triple-negative breast cancer is not recommended. However, there is still a need for further experimental and clinical research on the exact effects of these drugs on undesired immune cells exhaustion in breast cancer therapy.
NeoSeq: A New Method of Genomic Sequencing for Newborn Screening
Authors: wang huaiyan , yang yuqi , zhou lignna , wang yu , long wei , Yu Bin 
Published: July 2021

Abstract
Objective
To explore the clinical application of NeoSeq in newborn screening.
Methods
Based on the results obtained from traditional newborn screening (NBS), three cohorts were recruited into the present study: 36 true positive cases (TPC), 60 false-positive cases (FPC), and 100 negative cases. The dried blood spots of the infants were analyzed with NeoSeq, which is based on multiplex PCR amplicon sequencing.
Results
Overall, the sensitivity of both NeoSeq and traditional NBS projects was 55.6% (20/36) in the detection of TPC. NeoSeq detected disease-related genes in 20 of 36 TPC infants, while it could not identify these genes in eight children. Five cases (3.1%) with disease risk were found in the FPC and NC cohorts. There was a significant time difference in the diagnostic result cycles between the two methods − 10 days for NeoSeq vs. 43 days for traditional NBS.
Conclusions
NeoSeq is an effective method of genomic sequencing for newborn screening. It can detect most inborn errors of metabolism, reduce the rate of false positive results, shorten the reporting cycles, and reduce the screening cost.
Model-free Control of Manipulator in Task Space Containing Mismatched Uncertainty
Authors: Yang Xiaohui , Xu Zhenghong , Zhang Wenjie , Zhang Wei , Liu Peter Xiaoping 
Published: July 2021

Abstract
In this paper, a novel trajectory tracking control method for manipulator task space containing mismatched uncertainty is proposed. This paper considers the mismatched uncertainty that exists in the signal conversion between joint space and task space in the robotic arm system. The time delay estimation is employed to approximate the dynamic and kinematic parameters of the system to achieve model-free control. The time delay estimation errors is treated as part of the system disturbances and a disturbance observer based on an auxiliary control system capable of estimating both matched and mismatched disturbances is designed, which does not require additional design of adaptive laws to compensate for disturbances or upper bounds on the derivatives of disturbances. We transform the control error by a prescribed performance function to accomplish transient control of the error, and design a fast terminal sliding surface for the virtual control variables based on the backstepping design method to improve the convergence speed of the controller. Based on the Lyapunov criterion, the closedloop stability of the whole system is demonstrated. The feasibility and superiority of the method in this paper is demonstrated by numerical simulation compared with other control methods.
Correlation of Knee Instability With Alignment And Repetitive Physical Activity In Patients With Knee Osteoarthritis: A Cross-Sectional Study
Authors: Wada Makoto , Miyazaki Tsuyoshi , Yamamoto Yusuke , Sakamoto Takumi , Adachi Takahiro 
Published: July 2021

Abstract
Objectives. Malalignment, dynamic knee instability, and repetitive physical activity are considered biomechanical risk factors for knee osteoarthritis (KOA), though the correlations among these factors are poorly understood. The purpose of this study was to elucidate the relationship between knee instability and alignment, and to determine the effects of repetitive physical activity on knee instability in patients with KOA.Methods. The study subjects were 68 patients with radiographic tibiofemoral KOA and 68 control subjects. Each participant underwent clinical evaluation, muscle strength test, radiography, and knee instability test. Instability was evaluated before and after repetitive stepping exercise using triaxial accelerometer. Results. Mediolateral acceleration correlated (p<0.01) with two coronal alignments (mechanical axis; HKA and joint line convergent angle; JLCA). Pearson correlation coefficient was small (r=0.23-0.24) before but increased after stepping (r=0.28-0.33). Increased mediolateral acceleration after stepping correlated with JLCA (r=0.37, p<0.001) . There were significant differences in coronal alignments, gait speed, mediolateral acceleration, and accelerations in all directions between the control and KOA groups. Anteroposterior acceleration did not correlate with sagittal knee alignment. Multiple logistic regression analysis identified HKA/JLCA, and increased mediolateral acceleration after stepping as significant diagnostic predictors of KOA.Conclusion. We found a direct relationship between knee instability and knee alignment or repetitive physical activity. Repetitive stepping activity significantly increased mediolateral acceleration in KOA patients, compared to the control. Stepping increased the correlation between mediolateral acceleration and coronal alignment. In knees with large JLCA, repetitive stepping provided much larger mediolateral instability. Our results suggest that, in addition to JLCA, the increase in mediolateral acceleration after repetitive physical activity, possibly contributes to the development of KOA.Trial registrationTan-nan Regional Medical Center TRMC No. 2018-1
Synthesis of New Calixarene Derivatives and Evaluation of Their Cytotoxic Activity
Authors: Oguz Mehmet , Yildirim Ayse , Durmus Irem Mukaddes , Karakurt Serdar , Yilmaz Mustafa 
Published: July 2021

Abstract
Since calixarenes are more easily synthesized and functionalized than other supramolecules, they are compounds of interest in organic chemistry. In this study, the dihydrazide (3a and 3b) and diamino propyl (6a and 6b) derivatives of p-tert-butylcalix[4]arene and calix[4]arene were synthesized. Then the L-proline methyl ester substituted chlorocyclopropenium was reacted with the calix[4]arene derivatives (3a, 3b, 6a, and 6b) at room temperature in CH2Cl2 to obtain calix[4]arene superbase derivatives (4a, 4b, 7a, and 7b) in 75%, 60%, 70% and 55% yield, respectively. The synthesized compounds' structure was elucidated by using spectroscopic techniques (FTIR, 1H NMR, and 13C NMR ). The cytotoxic properties of the calix[4]arene superbase derivatives were investigated against different human cancerous cells, including A549, DLD-1, HEPG2, and PC-3, as well as human healthy epithelium cell line PNT1A. The cytotoxicity results showed that calix[4]arene superbase derivatives inhibited the proliferation of DLD-1, A549, HEPG2, and PC-3 cells in a dose-dependent manner. Compound 7a had the highest toxic effect on colorectal carcinoma (IC50: 4.7 µM), and the IC50 values were 18.5 µM and 74.4µM against human prostate and lung cancer cells, respectively. Furthermore, the compound 4b was found more effective on hepatocellular carcinoma cells (IC50: 210.2 µM). As a result, the synthesized calix[4]arene superbase derivatives can be developed to treat different human cancer cells. They can be considered as a preliminary result for molecular-level research.
Vibrio Gaelis sp. nov. Isolated From the Skin of Southern Atlantic Sharpnose-puffer (Canthigaster Figueiredoi)
Authors: de Azevedo Gustavo Pitta Reis , Mattsson Hannah K. , Tonon Luciane , Arruda Tatiane , Salazar Vinicius , Bielinski Vincent A. , Chagas Fernanda , Tschoeke Diogo A. , Thompson Cristiane C. , Thompson Fabiano L. 
Published: July 2021

Abstract
Description of a Gram-negative, motile, circular-shaped bacterial strain, designated A621T obtained from the skin of the pufferfish Canthigaster figuereidoi (Tetraodontidae Family), collected in Arraial do Cabo, Brazil. Optimum growth occurs at 20 - 28 °C in the presence of 3% NaCl. The Genome sequence of the novel isolate consisted of 4.224 Mb, 4,431 coding genes and G+C content of 44.5%. Genomic taxonomy analysis based on Average Amino Acid (AAI), Genome-to-Genome-Distance (GGDH) and phylogenetic reconstruction placed A621T (= CBAS 741T) into a new species of the genus Vibrio (Vibrio gaelis sp. nov.). The genome of the novel species contains 4 gene clusters (~56.17 Kbp in total) coding for different types of bioactive compounds that hint to several possible ecological roles in the pufferfish host.
Stratifin as a Novel Diagnostic Biomarker in Serum for Diffuse Alveolar Damage
Authors: Arakawa Noriaki , Ushiki Atsuhito , Abe Mitsuhiro , Matsuyama Shinichiro , Saito Yoshinobu , Kashiwada Takeru , Horimasu Yasushi , Gemma Akihiko , Tatsumi Koichiro , Hattori Noboru , Tsushima Kenji , Saito Kosuke , Nakamura Ryosuke , Toyoda Takeshi , Ogawa Kumiko , Sato Motonobu , Takamatsu Kazuhiko , Mori Kazuhiko , Nishiya Takayoshi , Izumi Takashi , Ohno Yasuo , Saito Yoshiro , Hanaoka Masayuki 
Published: July 2021

Abstract
Among the various histopathological patterns of drug-induced interstitial lung disease (DILD), diffuse alveolar damage (DAD) is associated with poor prognosis. However, there is no reliable biomarker for its accurate diagnosis. Here, we show stratifin/14-3-3σ (SFN) as a biomarker candidate found in a proteomic analysis. The study included two independent cohorts and controls (n = 432 samples). SFN was specifically elevated in DILD patients with DAD, and was superior to the known biomarkers, KL-6 and SP-D, in discrimination of DILD patients with DAD from patients with other DILD patterns or other lung diseases, including bacterial pneumonia. SFN was also increased in serum from patients with idiopathic DAD, and in lung tissues and bronchoalveolar lavage fluid of patients with DAD. In vitro analysis using the A549 cell line suggested that extracellular release of SFN occurred via p53 activation. We conclude that serum SFN is a promising biomarker for DAD diagnosis.
The Logic Fundamentals of Machine Consciousness: Theory of Tri-State
Authors: Wang Zhiwei , ZHOU Ao , LIU Xin 
Published: July 2021

Abstract
For a long time, the system of scientific methodology has been composed of logic, empirical (falsification), qualitative, quantitative and deterministic, and corresponding thinking tools. However, under the background of complexity science, the category of methodology should be changed, that is, on the basis of traditional methodology, non-classical logic, hierarchy, stereotype (topological invariant) and uncertainty should be added. This is also the main idea behind the “Thoery of Tri-state” in the first part of this paper. The core idea in the theory of “Tri-state” is “Tri-state Logic” (“positive | negative | uncertain state”). The ontology of “Tri-state Logic” aims to reveal the meta space-time movement law of things transforming from one form to another, that is, the coupling of time and space in the development of things, and the orientation and evolution of the continuity of things. The mathematical basis of “Tri-state Logic” is knot theory and dynamics theory. The second part of this paper designs a machine-consciousness model framework based on the “Theory of Tri-state” (Tri-state Logic). Its research starting point is the perspective of cognitive dynamics (cognitive psychology + dynamics), which is very different from the research ideas proposed by Minsky's “The Emotion Machine”. At the same time, this paper also tries to answer Turing's questions from different space-time dimensions, and gives an experimental idea of “kindergarten game” by comparing Turing's “imitation game”.