bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability Analysis and Control Technology of Gob-Side Entry Retaining with Double Roadways by Filling with High-Water Material in Gently inclined Coal Seam
Authors: Xie Shengrong , Wang En , Chen Dongdong , Li Hui , Jiang Zaisheng , Yang Hongzeng 
Published: June 2021

Abstract
Roadside filling body in traditional gob-side entry retaining (GER) has several shortcomings such as the insufficient support resistance, the inability to adapt to the deformation of surrounding rock and isolate the goaf effectively. Taking the GER with double roadways by filling with 1.8-m-wide high-water material in gently inclined coal seam of Zuozegou mine as a project case, the mechanical model of GER with double roadways in the gently inclined coal seam is constructed, and the reasonable width of the filling body of GER is verified by combining with the peak strength of high-water material. The FLAC3D numerical simulation method is used to study the distribution characteristics of stress and plastic zone of GER after being affected by the mining disturbance, and the failure range of surrounding rock of GER with double roadways is obtained. Based on this, a coupling control technology named anchor cables and bolts in the roof and solid coal + single props in entry-in support and goaf side of the outer roadway + anchor bolts in roadside high-water material + short anchor cables below the filling body is proposed and conducted in industrial test. Through the coupling methods of arranging borehole peeping and observing the convergences of surrounding rock, the stability of GER with double roadways is analyzed. The results show that GER with double roadways by filling with 1.8-m-wide high-water material has good control effect. The above research has played an active role in promoting the application of high-water material in roadside filling of GER.
Prognostic Implication of Isolated Pulmonary Nodules in Patients with a History of Breast Cancer
Authors: Zhao Weigang , Zhu Shu , Song Zuodong 
Published: June 2021

Abstract
Background: Isolated malignant pulmonary nodules were frequently seen in patients with breast cancer. These were metastasis from the breast cancer or new primary lung cancer. The role of surgery for such pulmonary nodules remains unclear.Methods: A total of 90 patients who underwent surgery for solitary malignant pulmonary nodules between January 2010 and April 2018 after curative operation for breast cancer were reviewed.Results: The pathologic diagnoses revealed 63 patients with primary lung cancer (PLC) and 27 patients with pulmonary metastatic breast cancer (MBC), which were divided into two groups. All patients were female with a mean age of 55.08±9.84 years (range 31-75). Age differences between the two groups were insignificant. Of the 63 patients with PLC, 55(87%) had a lobectomy with lymphadenctomy and 8(13%) had a limited resection, while the majority of patients (78%) with MBC had a limited resection. All nodules were adenocarcinomas and their mean diameter was 1.63±0.57cm. 7/55 of patients with PLC had N1 disease while 3/6 of those with MBC had involvement of N1 nodes. For all patients, the overall survival (OS) was 86.1% at 5 years and the disease free survival (DFS) was 86.0% at 5 years. Patients with PLC had the better surgical outcomes including OS and DFS than those with MBC did (94.2% versus 72.8%, p=0.017; 93.6% versus 63.9%, p=0.002).Conclusions: Surgical outcomes of isolated malignant pulmonary nodules in breast cancer patients were favorable. Surgery should be considered as an option for breast cancer patients with isolated pulmonary nodules.
A Case Report of Prolongation of Neuromuscular Blockade by Clindamycin in a Vegetarian
Authors: Liu Xiaojie , Yin Jihui , Hua Zhen , Chu Haichen 
Published: June 2021

Abstract
BackgroundPrevious study has illustrated that the factors can affect the duration of neuromuscular blockade. Vegetarian habits may affect osteoporosis and respiratory muscle tone.Case PresentationThe purpose of this report is to record the first unusual prolonged neuromuscular block by concomitant clindamycin in a vegetarian. ConclusionClinical doses of clindamycin may significantly prolong the neuromuscular blockade of “short-acting” no depolarizing muscle relaxants when the patient is so weak and vegetarian. This requires vigilance and routine monitoring of the neuromuscular junction by the anesthesiologist.
Breast Epithelial-myoepithelial Carcinoma With HER2 Gene Amplification: a Rare Case and Review of Literature
Authors: Hu Min , Yue Junqiu , Guo Fang , Jin Su , Wang Mingwei , Fang Na 
Published: June 2021

Abstract
Background: Epithelial-myoepithelial carcinoma is a very rare carcinoma that both luminal and myoepithelial components are malignant. What’s more, HER2 gene amplification has not been detected in the literature up to now. Herein, we report a rare case of breast epithelial-myoepithelial carcinoma with HER2 gene amplification.Case presentation: An 80-year-old woman presented with a mass in the upper outside region of her left breast. The core needle biopsy of the left breast mass revealed invasive breast carcinoma, and then modified radical mastectomy of left breast was performed. Macroscopically, the tumor was measured 6cm in diameter, and it was a solid and lobulated mass with areas of cystic and hemorrhagic lesions. Microscopically, the histological findings of tumor were consisted of 3 components. One component showed biphasic proliferation of both eosinophilic luminal epithelial and pale abluminal myoepithelial cells, arranging predominantly in dilated tubular architecture, which accounted for most of the lesion. Papillary architecture and eosinophilic secretions could be seen in some dilated ducts. The second component was proliferation of myoepithelial cells with pale cytoplasm around the glandular epithelium forming casing-like structures. The third component was few solid-appearing areas which was displayed a predominance of monophasic proliferation of myoepithelial cells. Both cell types exhibited enlarged and markedly atypical nuclei, with obvious nucleoli and prominent mitoses (up to 10-15/10 high power fields). Foci of infiltration were identified at the periphery of the lobules and the surrounding adipose tissue. Areas of central necrosis and stromal hyalinization could be seen. A diagnosis of EMC was made by morphology and immunohistochemistry. It's worth noting that HER2 gene amplification has not been detected in malignant adenomyoepitheIioma in the literature up to now; While in our present report, HER2 was 2+ membranous immunoreactivity, and then HER2 gene amplification was detected by fluorescence in situ hybridization. Conclusion: Accurate diagnosis of malignant adenomyoepitheIioma is challenging but of great importance, and the management of malignant adenomyoepitheIioma would be made according to histologic features.
Risk Factor Stratification of Lung Metastasis in Children and Adolescent Papillary Thyroid Cancer
Authors: Wang Liying , Liu Feng , Zhang Lingyun , Rui Shu , Liu Yang , Liu Wanting , Shen Feiyang , Huang Rui , Wei Tao , Gong Rixiang , Zhu Jingqiang , Luo Han , Li Zhihui 
Published: June 2021

Abstract
Background: Lung metastasis (LM) in pediatric papillary thyroid cancer (pPTC) is significantly higher than in adults. While spare information about pPTC and LM hampers to formulate specific guideline. Hence, we retrospectively analyzed the whole pPTCs in our center to investigate factors associated with LM and therapy outcomes.Materials and Methods: PTCs with age＜20 years who received initial operations in ourcenterfrom December 2008 to December 2018 were retrospectively reviewed. Clinicopathological information, treatment pipelineand outcomes were analyzed retrospectively.Results:Totally, 114 pPTC patients were enrolled in our study, LM was observed in 17 (14.9 %) cases. Significant risk factors associated with LM were age, sex, tumor size, multifocality, extrathyroidal extension, lymph node metastasis, number of metastatic lymph nodes (NMLNs)and postoperative stimulated thyroglobulin (sTg). NMLNs ＞14 was identified as an independent risk factor for LM by multivariate analysis (OR 25.166, 95% CI 2.814 - 225.009, p = 0.004) with a sensitivity of 86.7% and specificity of 81.1% for LM, which was verified by integrated meta-analysis. In terms ofresponse to radioiodine treatment in LM, 2 cases reached ‘‘excellent’’ response. ‘‘Biochemically incomplete’’, ‘‘structurally incomplete’’ and “indeterminate” were in 3,12, 2 of 17 patients respectively. Postoperative sTg was correlated with the response to therapy of LM in pPTCs(p = 0.003).Conclusion: LM was frequently observed in pPTCs. NMLNs ＞14 was an independent risk factor for LM in our study and other cohorts, and postoperative sTg was a potential predictor for the therapy outcome of LM in pPTCs.
Topic duplication and research waste at the ‘Overviews of systematic reviews’ level: Survey of overlapping overviews
Authors: Lunny Carole , Zhang Jia He , Chen Alyssa , Neelakant Trish , Shinger Gavindeep , Stevens Adrienne , Tasnim Sara , Sadeghipouya Shadi , Adams Stephen , Zheng Yi Wen , Lin Lester , Yang Pei Hsuan , Dosanjh Manpreet , Ngsee Peter , Ellis Ursula , Shea Beverley J. , Reid Emma K. , Wright James M. 
Published: June 2021

Abstract
Background
Multiple overviews of systematic reviews conducted on the same topic (“overlapping overviews”) represent a waste of research resources and can confuse or mislead clinicians and policymakers. We aimed to assess the frequency and characteristics of published overviews addressing the same clinical question or topic.
Methods
We used MEDLINE, Epistemonikos and Cochrane databases to locate overviews that: focused on synthesising reviews; conducted systematic searches; had a methods section; and examined a health intervention or clinical treatment. We then determined which overviews addressed the same or overlapping populations/settings, interventions, and outcomes [PIO]). Overlap in topic was defined as: duplication of PIO elements, not representing an update of a previous overview, and not a replication for quality purposes.
Results
Of 541 overviews located (2000–2018), 178 (33%) overlapped with another overview addressing a similar PIO. The topics of overlapping overviews fell within 13 WHO ICD-10 medical classifications, and there were 65 overlapping topics in total. The most prevalent topic with overlap across 7 overviews was smoking cessation (pharmacologic and non-pharmacologic interventions). Five overlapping overviews related to acupuncture for pain, 5 addressed cannabinoids for pain and symptoms, and 5 addressed exercise for bone and muscle health. For 15/65 (22%) of these topics, one author was involved in at least two of the overlapping overviews.
Conclusions
We found significant duplication and unnecessary overlap across overviews. To avoid waste and redundancy, protocols of overviews should be registered in a targeted database, and overviews should cite other studies on similar topic with a rationale.
Involvement of Ethylene in Reversal of Salt Stress by Salicylic acid in Presence of Sulfur in Mustard (Brassica juncea L.)
Authors: Rasheed Faisal , Sehar Zebus , Fatma Mehar , Iqbal Noushina , Masood Asim , Anjum Naser , Khan Nafees 
Published: June 2021

Abstract
The involvement of ethylene in reversal of salt stress inhibited photosynthetic activity and growth by salicylic acid (SA) together with sulfur (S) was studied in mustard (Brassica juncea L.) plants. Application of SA (0.5 mM) plus SO42- (2.0 mM) improved photosynthetic activity through markedly increased S-assimilation, antioxidant enzymes activity and optimized ethylene and glutathione (GSH) production for reduced reactive oxygen species (ROS) in plants under 50 mM NaCl stress. As SA acts as an inhibitor of ethylene, and S-assimilation is associated with ethylene synthesis, we tried to figure out the interaction of ethylene in SA and SO42- mediated salt tolerance. The involvement of ethylene was studied by supplementing salt treated plants with 200 µL L-1 ethephon (an ethylene-releasing compound) or 100 µM norbornadiene (NBD, ethylene action inhibitor) to SA and SO42- treatments. The ethephon application to salt treated plants suppressed stress ethylene and optimized ethylene formation and increased ethylene sensitivity to enhance photosynthesis of plants by affecting antioxidative capacity of plants. Application of NBD to plants receiving SA plus SO42- in presence of salt showed inhibited photosynthetic characteristics, stomatal behavior and growth. These plants exhibited minimal capacity of S-assimilation and antioxidant enzymes activity and GSH content. This explained that ethylene was involved in the reversal of salt stress by SA plus SO42-. Thus, the study showed that ethylene intervenes the effect of SA in the presence of SO42- to upregulate the antioxidants that lead to increased S-assimilation, and imparted tolerance to salt in mustard plants.
Onsite versus remote working: the impact on satisfaction, productivity, and performance of medical call center workers
Authors: Alfaleh Amjad , Alkattan Abdullah , Alageel Alaa , Salah Mohammed , Almutairi Mona , Sagor Khlood , Alabdulkareem Khaled 
Published: June 2021

Abstract
Background
Job satisfaction is determined as the measure to know the individuals’ feelings toward their work. The working conditions that can affect the call center agents’ satisfaction, and performance have received particular concern.
Methods
This study included 124 agents working in a governmental medical call center in Saudi Arabia. Each agent was receiving a questionnaire that investigates their satisfaction, productivity and performance during working in the medical call center.
Results
Seventy-seven physicians working onsite were compared to 47 physicians working in the medical call center remotely. Onsite agents were more satisfied concerning job nature, supervisor support, productivity and performance compared to remote agents. Overall, general satisfaction was more seen in physicians working onsite as opposed to remote workers in the medical call center in Saudi Arabia (64.90% vs. 54.25%, [p-value < 0.01]).
Conclusion
It was found that onsite agents were significantly more satisfied in most investigated aspects compared with remote agents.
Bi-modular fusion proteins, a versatile therapeutic tool for re-directing a pre-existing Epstein-Barr virus antibody response towards defined target cells
Authors: Gamain Benoît , Brousse Carine , Rainey Nathan , Diallo Béré , Paquereau Clara-Eva , Desrames Alexandra , Ceputyte Jolita , Semblat Jean-Philippe , Bertrand Olivier , Gangnard Stéphane , Teillaud Jean-Luc , CHENE Arnaud 
Published: June 2021

Abstract
Industrial production of therapeutic monoclonal antibodies is mostly performed in eukaryotic-based systems, allowing post-translational modifications mandatory for their functional activity. Nevertheless, the resulting elevated product cost limits therapy access to some patients, thus increasing medical inequality. To address this limitation, we conceptualized a novel immunotherapeutic approach aiming at redirecting a pre-existing polyclonal antibody response against Epstein-Barr virus (EBV) towards defined target cells. We engineered bi-modular fusion proteins (BMFPs), notably expressible in bacteria-based systems, comprising a Fc-deficient binding moiety (Nanobody, scFv) specifically targeting an antigen expressed at the surface of a target cell, fused to the P18 EBV antigen, which would recruit circulating endogenous anti-P18 IgG in individuals chronically infected by EBV. Opsonization of BMFP-coated target cells efficiently triggered antibody-mediated clearing effector mechanisms in vitro, such as the complement cascade, erythrophagocytosis by macrophages and FcγRIII-mediated activation of cellular pathways leading to antibody-dependent cell-mediated cytotoxicity (ADCC). When assessed in a mouse tumour model, therapy performed with an anti-huCD20 BMFP significantly led to increased mice survival and total cancer remission in some animals. These results indicate that BMFPs are versatile tools for redirecting an Epstein-Barr virus pre-existing immune antibody response towards pre-defined target cells and could represent potent and useful therapeutic molecules to treat a broad range of diseases.
Entomopathogenic nematode-gastropod interactions
Authors: Schurkman Jacob , Dillman Adler R. 
Published: June 2021

Abstract
Entomopathogenic nematodes (EPNs) infect and kill insects and have been successfully used in the biological control of some insect pests. Slugs and snails are known to be significant pests of agriculture and serve as vectors for disease-causing microbes that can affect crops and humans. The potential of EPNs to be used in the biological control of gastropods has not been well-studied. The few studies that have been performed on the efficacy of EPNs in controlling gastropod pests and vectors were reviewed. Suggested criteria for further assessments of EPN-gastropod interactions are: Dose of EPNs used, length of infection assays, host biology, nematode biology and development, and Koch’s postulates. There are provocative data suggesting that EPNs may be useful biological control agents against gastropod pests of agriculture and vectors of disease, though additional studies using the suggested criteria are needed, including the publication of negative data or studies where EPNs were not efficacious or successful in controlling gastropods.
Reporte anual de visibilidad e impacto 2021
Authors: Fernández-Osorio Andrés Eduardo , Miron Marina 
Published: June 2021

Este reporte compila los aportes académicos de la RCGJMC a la investigación y el debate sobre el uso legítimo del poder y su adecuado ejercicio en relación con los intereses nacionales, para el beneficio de la formulación de políticas y la gestión pública.
The effect of nurse case coordination on management of chronic conditions
Authors: Mittal Aayush 
Published: June 2021

A clinical decision report using:
Ishani A, Greer N, Taylor BC, et al. Effect of nurse case management compared with usual care on controlling cardiovascular risk factors in patients with diabetes: a randomized controlled trial. Diabetes Care. 2011;34(8):1689-1694. https://doi.org/10.2337/dc10-2121
for a patient requiring care coordination for management of hypertension, diabetes, and hyperlipidemia.
The Determinants of External Auditors’ Independence for Politically Connected Firms in Malaysia
Authors: I.K Norziaton , Muharam Nurul Nadhirah 
Published: June 2021

The auditing profession is a major concern for stakeholders and has been in a quagmire for the past years. To overcome the concern, client firms must take the initiative to assure that the management does not put pressure on the external auditors. Therefore, firms need to take part in positively influencing external auditors‟ independence to reduce the complexity of audit procedures, and consequently, improve external auditors‟ independence. Thus, the determinants of factors are needed to assure and maintain the independence of the external auditors at any time to perform their audit work. Hence, the main objective of this study is to examine the determinants of external auditors‟ independence among politically connected firms in Malaysia. The determinants are classified into two which are, first, auditor attributes namely, audit tenure and non-audit fee, and second, audit committee characteristics which consist of audit committee‟s independence and audit committee‟s diligence. Four hypotheses were developed and tested using a total of 46 sample firms from 2014 to 2018 with 230 firm-year observations. This study used secondary data from which the information was obtained from annual reports and DataStream. The results reveal that non-audit fee and audit committee‟s diligence influenced external auditors‟ independence, whereas audit tenure and audit committee‟s independence did not. Altogether, this study has provided useful information and implications for the professional bodies and Bursa Malaysia to help strengthen the principles of auditors‟ independence in politically connected firms.
Keywords: Auditor Attributes, Audit Committee, Auditor Independence, Political Connection
The Potential Use of Collaborative ESP Testing Implementation Framework (CETIF) in Addressing Underlying Issues in ESP Curriculum and Testing Faced by English Lecturers Teaching Engineering Students
Authors: Ahmad Norkhairi , Muhammad Ahmad Mazli , Jamil Asiah 
Published: June 2021

Albeit the presence of educational quality initiatives like Outcome Based Education (OBE) and Common European Framework of Reference (CEFR) to enhance the implementation and outcome of university language courses, deep seated issues continue to leave a trail of shortcomings in the outcomes and abilities of university graduates in terms of language and communication. Detailed qualitative responses via purposive sampling elicited from experienced English lecturers teaching ESP courses to engineering students at universities in Malaysia, revealed underlying issues that stemmed from the systemic aspects of the engineering curriculum planning and execution. Issues like inaccurate course positioning in programme structure and marginalized roles of English lecturers that affect ESP courses implementation were identified via contextual analysis. Guided by the list of issues and theoretical underpinnings, a framework was proposed for mitigation efforts. The collaborative ESP testing implementation framework (CETIF) which is tied-up to language testing principles of Validity, Reliability, Impact, Practicality, and Quality management (VRIPQ) and ESP principles like specificity, authenticity and learners’ needs, embodies mitigation efforts and synergy between practitioners like English lecturers, engineering lecturers, and industry personnel. Discussion on the potential use of CETIF is put forth and the potential benefits to be yielded include enhancement of English lecturers’ professional roles, forming of positive beliefs and views and cultivation of good ESP testing practices.
La Organización de las Naciones Unidas a los 75 años. Cómo los retos de hoy configurarán los siguientes 25 años
Authors: Malon David M. , Day Adam 
Published: June 2021

En el marco del 75 aniversario de la Organización de las Naciones Unidas (onu), celebrado en 2020, el artículo hace un balance de la situación y señala cómo la fuerza que ha perdido el multilateralismo en muchos de los temas más apremiantes a nivel global ha repercutido negativamente varias de sus actividades fundamentales. La situación se evalúa en cuatro grandes campos de acción de las Naciones Unidas: paz y seguridad, desarrollo internacional, ayuda humanitaria y derechos humanos, y se argumenta que varios logros importantes alcanzados en cada rubro actualmente corren el riesgo de sufrir un retroceso o diluirse. En cada uno de estos grandes temas, se analizan los principales retos que enfrenta la organización, al tiempo que se proponen algunas líneas de acción que deberían profundizarse o hacia las que la onu debería reenfocar su labor.
La reflexión resulta más que pertinente dado que los retos que el mundo enfrenta hoy en día –particularmente los relacionados con el cambio climático, pero también con los gigantescos cambios demográficos de las décadas por venir y el impacto de la tecnología– sólo pueden atenderse mediante la acción colectiva, y las Naciones Unidades deberían desempeñar un rol central al respecto.