bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Value of Nomogram Based on Kyoto Classification of Gastritis to Diagnosis of Gastric Cancer
Authors: Lin Jiejun , Su Huang , Guan Yaqi , Zhou Qingjie , Pan Jie , Zhou Leying 
Published: September 2021

Abstract
Background and Aim. It is of importance to predict the risk of gastric cancer (GC) for endoscopists because early detection of GC determines the determines the selection of best treatment strategy and the prognosis of patients. The aim of the study was to evaluate the utility of a predictive nomogram based on Kyoto classification of gastritis for GC. Methods. It was a retrospective study that included 2639 patients who received esophagogastroduodenoscopy and serum pepsinogen (PG) assay from January 2020 to November 2020 at the Endoscopy Center of the Department of Gastroenterology, Wenzhou Central Hospital. Routine biopsy was conducted to determine the benign and malignant lesions pathologically. All cases were randomly divided into the training set (70%) and the validation set (30%) by using bootstrap method. A nomogram was formulated according to multivariate analysis of training set. The predictive accuracy and discriminative ability of the nomogram were assessed by concordance index (C-index), area under the curve (AUC) of receiver operating characteristic curve (ROC) as well as calibration curve and were validated by validation set.Results. Multivariate analysis indicated that age, sex, PG I/II ratio and Kyoto classification scores were independent predictive variables for GC. The C-index of the nomogram of the training set was 0.79 (95% CI: 0.74 to 0.84) and the AUC of ROC is 0.79. The calibration curve of the nomogram demonstrated an optimal agreement between predicted probability and observed probability of the risk of GC. In the validation set, the C-index was 0.86 (95% CI: 0.79 to 0.94) with a calibration curve of better concurrence.Conclusion. The nomogram formulated was proven to be of high predictive value for GC.
A Retrospective Study of Micturition Interruption Exercise to Accelerate the Recovery of Urinary Incontinence after Radical Prostatectomy
Authors: Duan Yue , He Kangjie , Yang Xiangnan , Zhu Zheng , Dai Di , Zhang Jiacheng , Chen Jiaxing 
Published: September 2021

Abstract
Purpose: To explore the effectiveness of micturition interruption exercise in improving the incidence of urinary incontinence after radical prostatectomy.Materials and Methods: With a retrospective case-control study, 96 patients admitted in the Second Affiliated Hospital of Zhejiang Chinese Medical University from August 2016 to August 2020 and underwent radical prostatectomy were collected as the subjects. Those patients who used micturition interruption exercise (n=48)were set as the observation group, and the control group was collected according to the ratio of 1:1, the patients used Kegel exercise (n=48). To compare the rehabilitation of urinary incontinence in patients and the effect of training compliance on rehabilitation.Results: The recovery time of urinary incontinence in the observation group was significantly shorter than that of the control group. In the observation group, 83.3% of patients with training compliance reached an average or above, while the control group only accounted for 58.3%. International Consultation on Incontinence Questionnaire Short-Form score of the observation group was lower than that of the control group after surgery. Spearman analysis suggests that there is a negative correlation between the postoperative urinary incontinence recovery time and compliance with the micturition interruption exercise.Conclusions: Micturition interruption exercise could improve the patient's exercise compliance and shorten the recovery time of urinary incontinence after radical prostatectomy.
Optimization, validation and initial clinical implications of a Luminex-based immunoassay for the quantification of Fragile X Protein from Dried Blood Spots
Authors: Boggs Anna E , Schmitt Lauren M , McLane Richard D , Adayev Tatyana , LaFauci Giuseppe , Dominick Kelli C. , Gross Christina , Horn Paul S , Erickson Craig A 
Published: September 2021

Abstract
BackgroundFragile X syndrome (FXS) is the most common inherited form of intellectual disability affecting 1 in 4,000 males and 1 in 6-8,000 females. FXS is caused by a trinucleotide expansion in the 5’UTR of the Fragile X Mental Retardation (FMR1) gene which in full mutation carriers (>200 repeats) leads to hypermethylation and transcriptional silencing of the gene and lack of expression of Fragile X Protein (FXP, formerly known as Fragile X Mental Retardation Protein, FMRP). Phenotypic presentation of FXS is highly variable, and molecular markers explaining or predicting this variability are lacking. Recent studies suggest that trace amounts of FXP can be detected even in fully methylated individuals and may have clinical relevance; however, the lack of available reproducible, sensitive assays to detect FXP in peripheral tissue makes evaluation of peripheral FXP as a source of clinical variability challenging. MethodsWe optimized a Luminex-based assay to detect FXP in dried blot spots for increased reproducibility and sensitivity by improving reagent concentrations and buffer conditions. The optimized assay was used to quantify FXP in 187 individuals (101 males, 86 females; 0-78.4 years) including 35 typically developing controls (24 males, 11 females), 103 individuals carrying full mutations (70 males, 33 females), and 49 individuals with premutations (7 males, 42 females). A subset of these individuals showed repeat number or methylation mosaicism. We investigated the clinical relevance of peripheral FXP levels by examining its relationship with general intellectual functioning in a subset of individuals with available IQ scores. ResultsWe show that the optimized assay is highly reproducible and detects a wide range of FXP levels. Mosaic individuals had, on average, higher FXP levels than fully methylated individuals, and trace amounts of FXP were consistently detectable in a subset of individuals with full mutation FXS. IQ scores were positively correlated with peripheral FXP levels in male and female individuals with full mutation FXS. ConclusionsWe demonstrate that our optimized Luminex-based assay to detect FXP is reproducible, highly sensitive, and related to the core intellectual disability phenotype. Further, our data suggest that trace amounts of FXP detectable in dried blood spots of individuals with FXS could be clinically relevant and may be used to stratify individuals with FXS for optimized treatment. Future studies are needed with larger sample sizes, evaluating FXP across development and expanded analysis of the relevance of FXP levels for behavioral and electrophysiological phenotypes in FXS.
The influence of geomagnetic storms on the quality of magnetotelluric impedance
Authors: Chen Hao , Mizunaga Hideki , Tanaka Toshiaki 
Published: September 2021

Abstract
Magnetotelluric field data contain natural electromagnetic signals and artificial noise sources (instrumental, anthropogenic, etc.). Not all available time-series data contain usable information of the electrical conductivity distribution at depth with a low signal-to-noise ratio. The variation of the natural electromagnetic signal increases dramatically in a strong geomagnetic storm, and the signal-to-noise ratio increases. A more reliable impedance may be obtained using the storm data in a noisy environment. Three field data observed at mid-latitude were used to investigate the effect of geomagnetic storms on MT impedance quality. We mainly combined the coherence between the electric and magnetic fields and the result of MT impedance to evaluate the MT impedance quality; we also used the polarization direction, linear coherence and amplitude ratio between the local and remote magnetic field to evaluate the data quality in the noisy environments. The case studies showed that the utilization of the data observed during the geomagnetic storm could overcome the local noise and bring a reliable impedance.
Paraquat-induced intracellular Zn2+ dysregulation causes dopaminergic degeneration in the substantia nigra, but not in the striatum
Authors: Tamura Haruna , Nishio Ryusuke , Saeki Nana , Katahira Misa , Morioka Hiroki , Tamano Haruna , Takeda Atsushi 
Published: September 2021

Abstract
Parkinson's disease (PD) is characterized by a selective death of nigrostriatal dopaminergic neurons, while the difference in the vulnerability to the death between the substantia nigra pars compacta (SNpc) and the striatum is poorly understood. Here we tested the difference focused on paraquat (PQ)-induced intracellular Zn2+ toxicity via extracellular glutamate accumulation. When PQ was locally injected into the SNpc and the striatum, dopaminergic degeneration was observed in the SNpc, but not in the striatum. Intracellular hydrogen peroxide (H2O2) produced by PQ was increased in both the SNpc and the striatum. In contrast, extracellular glutamate accumulation was observed only in the SNpc and rescued in the presence of N-(p-amylcinnamoyl)anthranilic acid (ACA), a blocker of the transient receptor potential melastatin 2 (TRPM2) cation channels. PQ increased intracellular Zn2+ level in the SNpc, but not in the striatum. The increase was rescued by 1-naphthyl acetyl spermine (NASPM), a selective blocker of Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors. PQ-induced dopaminergic degeneration in the SNpc was rescued by ACA, NASPM, and GBR, a dopamine reuptake inhibitor. The present study indicates intracellular H2O2 produced by PQ, which is taken up through dopamine transporters, is retrogradely transported to presynaptic glutamatergic terminals, activates TRPM2 channels, accumulates glutamate in the extracellular compartment, and induces intracellular Zn2+ dysregulation via Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptor activation, resulting in dopaminergic degeneration in the SNpc. However, H2O2 signaling is not the case in the striatum. Paraquat-induced Zn2+ dysregulation plays a key role for neurodegeneration in the SNpc, but not in the striatum.
Eugenol and Lippia Alba Essential Oils as Effective Anesthetics for the Amazonian Freshwater Stingray Potamotrygon Wallacei (Chondrichthyes, Potamotrygonidae)
Authors: de Lima Cristiano Lopes , Morales-Gamba Ruben Dario , Neto Thiago Santana Malcher , Barcellos José Fernando Marques , Heinzmann Berta Maria , Schmidt Denise , Baldisserotto Bernardo , MARCON JAYDIONE LUIZ 
Published: September 2021

Abstract
This study assessed the potential of eugenol and the essential oil of Lippia alba (EOLA) in providing suitable anesthetic induction and recovery times, and their consequent effects on the blood and respiratory physiology, as well as the gill architecture of an Amazonian freshwater stingray, Potamotrygon wallacei, at the onset of the anesthetic event and after 48 h of recovery. Juveniles of P. wallacei (n = 12) were exposed to increasing concentrations of eugenol (75, 100, 125 and 150 µL L− 1) and EOLA (150, 175, 200 and 225 µL L− 1) in an immersion bath. Anesthetic induction was found to be faster with the use of eugenol compared to EOLA. On the other hand, the stingrays anesthetized with eugenol displayed a longer recovery time than those exposed to EOLA. The highest concentrations of eugenol caused moderate to severe histological changes in the gills. No significant changes were found for hematocrit and plasma metabolites in the stingrays anesthetized with all concentrations of both eugenol and EOLA just after the onset of anesthetic action, when compared to those recovered after 48 hours. Investigations regarding the potential use of these natural anesthetics are unprecedented for freshwater stingray species and 200 µL L− 1 EOLA is recommended as the most suitable anesthetic for use in juveniles of P. wallacei.
Development of New Catalytic Pigments: Dual Functional SiO2/TiO2-x Amorphous Photonic Crystals for Non-Iridescent Structural Color and Enhanced Photocatalytic Activity
Authors: Feng Li , Wang Fen , Xu Ze , Luo Hongjie , Zhao Ting , Zhu Jianfeng , Qin Yi 
Published: September 2021

Abstract
Biomimetic synthesis of amorphous photonic crystals (APCs) is a significant approach to obtain non-iridescent structural colors. However, the structural colors of artificially prepared APCs are dim or even white due to the influence of incoherent scattering. In this paper, we present an innovative method was proposed to combine APCs with black TiO2-x to construct non-iridescent structural color pigments with high visibility and photocatalytic activity. Due to absorption of incoherent scattered light by black TiO2-x, the color saturation of structural colors has been significantly increased. In addition, the utilization rate of photogenic carriers was effectively enhanced by slow light effect generated from pseudo-band gap of SiO2 APCs with TiO2-x absorbed full spectrum. The tone and color saturation of catalytic pigments are controlled by the diameter of SiO2 nanospheres and the ration of TiO2-x nanoparticles, which provides a controllable application study in color related fields such as artwork, environmental coatings and textiles.
Preparation and Properties of Naringin Epoxy/UiO-66 Composites
Authors: Du Yonggang , Shi Gonghui , Wang Hui , Zhao Ge , Li Wei , Liu Chuanfang , Zhao Zilong 
Published: September 2021

Abstract
The novel bio-based epoxy resin based on naringenin was synthesized. The naringenin epoxy/UiO-66 composites were prepared by casting process with UiO-66 as modifier and maleic anhydride as curing agent. The influences of UiO-66 content on mechanical properties, thermal stability and flame retardancy of naringenin epoxy/UiO-66 composites were investigated. The results showed that the impact strength, glass transition temperature and limiting oxygen index of pure naringenin epoxy resin were 2.0 kJ/m2, 96 ℃ and 1.2% higher than that of di-glycidyl ether of bisphenol A (DGEBA), respectively. UiO-66 can significantly improve the impact strength of naringenin epoxy resin while assisting improve its flame retardancy. When UiO-66 content was 4 wt%, the impact strength and limiting oxygen index of the naringenin epoxy/UiO-66 composite were 7.6 kJ/m2 and 24.5%, which were 85.4% and 3.5% higher than that of pure naringin epoxy resin, respectively.
The polarisation of remote work
Authors: Braesemann Fabian , Stephany Fabian , Teutloff Ole , Kässi Otto , Graham Mark , Lehdonvirta Vili 
Published: September 2021

Abstract

The Covid-19 pandemic has led to the rise of remote work with consequences for the global division of work. Remote work could connect labour markets, but it could also increase spatial polarisation. However, our understanding of the geographies of remote work is limited. Specifically, does remote work bring jobs to rural areas or is it concentrating in large cities, and how do skill requirements affect competition for jobs and wages? We use data from a fully remote labour market - an online labour platform - to show that remote work is polarised along three dimensions. First, countries are globally divided: North American, European, and South Asian remote workers attract most jobs, while many Global South countries participate only marginally. Secondly, remote jobs are pulled to urban regions; rural areas fall behind. Thirdly, remote work is polarised along the skill axis: workers with in-demand skills attract profitable jobs, while others face intense competition and obtain low wages. The findings suggest that remote work is shaped by agglomerative forces, which are deepening the gap between urban and rural areas. To make remote work an effective tool for rural development, it needs to be embedded in local skill-building and labour market programmes.
Prognostic significance of carbohydrate antigen 125 in acute heart failure: a prospective comparative study with N-terminal pro-B-type natriuretic peptide
Authors: Zhang Ji , Li Wenhua , Cai Gaojun , Xiao Jianqiang , Hui Jie , Shi Ganwei , Yu Lei , Xue Sheliang 
Published: September 2021

Abstract
Background

In acute heart failure (AHF), elevated carbohydrate antigen 125 (CA125) and N-terminal pro-B-type natriuretic peptide (NTproBNP) have shown to correlate with adverse events. We sought to quantify their prognostic usefulness in predicting the 6-month combined endpoint of death/heart failure readmission.
Methods

The study includes 352 patients admitted for AHF. The primary endpoint was 6-month combined endpoint of death/AHF rehospitalization. CA125 and NTproBNP were dichotomized according to the best cut-offs to predict 6-month primary endpoint. By multivariate Cox regression analysis, the independent association of CA125 and NTproBNP with the primary endpoint was assessed, and their incremental prognostic utility evaluated by net reclassification improvement (NRI) and integrated discrimination improvement (IDI) index.
Results

A total of 47 (13.4%) deaths and 113 (32.1%) AHF rehospitalizations were identified at 6-month follow-up. The subjects with CA125 ≥ 39.7 U/ml and NTproBNP ≥ 3900 pg/ml had significantly higher cumulative event rates (56.1% vs. 33.3% and 53.3% vs. 33.8%, both P < 0.001). Elevated CA125 (HR 1.93; 95%CI [1.32–2.83]; P = 0.001) was associated with higher HR than NTproBNP ≥ 3900 pg/ml (HR 1.71; 95%CI [1.19–2.48]; P = 0.004) after adjusting for established risk factors. Elevated CA125 still independently predicted adverse events when both CA125 and NTproBNP were entered together in the same multivariate model. Furthermore, risk reclassification analyses demonstrated significant improvements in NRI of 22.3% (P = 0.014) and IDI of 2.7% (P = 0.012) when adding CA125 to the base model + NTproBNP.
Conclusions

Elevated CA125 and NTproBNP predicted adverse outcomes in AHF patients. CA125 added prognostic value to NTproBNP, and thus, their combination conferred greater predictive capacity.
Kooperation an inklusiven Schulen: Zur Zusammenarbeit in einer inklusionsbezogenen Fortbildungsreihe und in der schulischen Praxis aus Sicht von Lehrkräften
Authors: Müller Ulrike Beate , Kuhl Poldi 
Published: September 2021

Kooperation gilt als ein Merkmal guter Schulen und erfolgreicher Schulentwicklung. Insbesondere an Schulen, die erfolgreich inklusiv arbeiten, wird Kooperation systematisch und auf einem hohen Niveau umgesetzt. Für ausgeprägte Formen der Kooperation sind allerdings langfristige und komplexe Interventionsformen bedeutsam, welche es in Form von Aus- und Weiterbildung von Lehrpersonen – insbesondere im Bereich der inklusiven Schulentwicklung – noch nicht in ausreichendem Maße gibt. Ein Schulentwicklungsprogramm, welches zur Professionalisierung von Lehrkräften im Umgang mit Heterogenität beitragen soll, ist Jede/r ist besonders (JIB) der Deutschen Schulakademie (DSA). Die zweite, zweijährige Zirkelrunde von JIB mit 24 Schulen in fünf Bundesländern wurde von 2017 bis 2020 wissenschaftlich mithilfe eines Mixed-Method-Ansatzes begleitet. Auf Grundlage des Modells zum Fortbildungserfolg nach Kirkpatrick wurde Kooperation innerhalb der Fortbildung und an den teilnehmenden Schulen untersucht. Ergebnisse aus drei Teilstudien weisen darauf hin, dass innerhalb der Fortbildung JIB erfolgreich kooperiert wird, dass Kooperation bedeutsam ist für die Umsetzung schulischer Entwicklungsziele und dass im Laufe der zwei Jahre von JIB das gemeinsame pädagogische Verständnis innerhalb der Kollegien und die außerschulische Zusammenarbeit an den JIB-Schulen weiterentwickelt werden konnten.

Abstract
Cooperation is a feature of high quality schools and successful school development. Especially schools that work successfully inclusive, cooperate systematically and at high levels. For elaborated forms of cooperation, long-term and extensive teacher training programmes are needed. A programme of school development that is set to qualify teachers to cope with heterogeneity, is JIB (Everyone is special) by the German School Academy. From 2017 to 2020 the second, two year term of JIB with 24 schools in five federal states in Germany was scientifically evaluated by a mixed-method study. Using the model of Kirkpatrick addressing success of training programmes, cooperation was analysed within the training programme JIB and in schools. Findings of three study parts suggest a successful way of cooperating within the teacher training programme, a significant role of cooperation in the realization of school development goals and an improvement of the collective pedagogical comprehension among teacher councils and of cooperation between parents and schools.
Mathematical simulation of air-water flow along Ski Jump Jet
Authors: Ahmadpour Roghayeh , Sarkardeh Hamed , Azamathulla Hazi 
Published: September 2021

AbstractIn the present study, using a quasi 3D analytical simulation, air concentration distribution in ski jump generated jet is calculated. A numerical simulation is also performed to verify the results of the analytical model in parallel with the available experimental and other analytical data. By solving continuity and momentum equations in the case of air-water flow for three different cases, it was confirmed that the air concentrations along the ski jet are uniquely linked to the relative black water core length. Results showed that the black water core length is also influenced by the approach flow depth, Froude number, geometrical parameters of ski jump and the chute bottom angle. Finally, an analytical equation is proposed to predict the air concentration distribution along the ski jump jet regarding different hydraulic and geometric parameters. By calculating the velocity profiles along the jet, it showed that increasing the air concentration reduces the jet velocity profile.
Selective Inhibitors of Histone Deacetylase 10 (HDAC-10)
Authors: Pojani Eftiola , Barlocco Daniela 
Published: September 2021

:
Histone acetylation balance is one epigenetic mechanism controlling gene expression associated with disease progression. It has been observed that histone deacetylase 10 (HDAC-10) isozyme contributes to the chemotherapy resistance; in addition, the poor clinical outcome observed in patients with aggressive solid tumors, such as neuroblastoma, has been associated with its overexpression. Moreover, HDAC-10 selective inhibition suppresses the autophagic response, thus providing an improved risk-benefit profile compared to cytotoxic cancer chemotherapy drugs. On these bases, HDAC-10 is becoming an emerging target for drug design.
Due to the rapid progress in the development of next-generation HDAC inhibitors, this review article aims to provide an overview on novel selective or dual HDAC-8/10 inhibitors, as new leads for cancer chemotherapy, able to avoid the severe side-effects of several actual approved “pan” HDAC inhibitors.
A literature search was conducted in MedLine, PubMed, Caplus, SciFinder Scholar databases from 2015 to the present.
Since the disclosure that the HDAC-6 inhibitor Tubastatin A was able to bind HDAC-10 efficiently, several related analogues were synthesized and tested. Both tricyclic (25-30) and bicyclic (31-42) derivatives were considered. The best pharmacological profile was shown by 36 (HDAC-10 pIC50 = 8.4 and pIC50 towards Class I HDACs from 5.2–6.4). In parallel, based on the evidence that high levels of HDAC-8 are a marker of poor prognosis in neuroblastoma treatment, dual HDAC-8/10 inhibitors were designed. The hydroxamic acid TH34 (HDAC-8 and 10 IC50 = 1.9 µM and 7.7 µM, respectively) and the hybrid derivatives 46d, 46e and 46g were the most promising both in terms of potency and selectivity.
Literature surveys indicate several structural requirements for inhibitory potency and selectivity towards HDAC-10, e.g., electrostatic and/or hydrogen bond interactions with E274 and complementarity to the P(E,A) CE motif helix.