bluuebunny/crossref_metadata_2025_split huggingface dataset:
Veno-occlusive unloading of the heart reduces infarct size in experimental ischemia–reperfusion
Authors: Hansen Esben Søvsø Szocska , Madsen Tobias Lynge , Wood Gregory , Granfeldt Asger , Bøgh Nikolaj , Tofig Bawer Jalal , Agger Peter , Lindhardt Jakob Lykke , Poulsen Christian Bo , Bøtker Hans Erik , Kim Won Yong 
Published: February 2021

AbstractMechanical unloading of the left ventricle reduces infarct size after acute myocardial infarction by reducing cardiac work. Left ventricular veno-occlusive unloading reduces cardiac work and may reduce ischemia and reperfusion injury. In a porcine model of myocardial ischemia–reperfusion injury we randomized 18 pigs to either control or veno-occlusive unloading using a balloon engaged from the femoral vein into the inferior caval vein and inflated at onset of ischemia. Evans blue and 2,3,5-triphenyltetrazolium chloride were used to determine the myocardial area at risk and infarct size, respectively. Pressure–volume loops were recorded to calculate cardiac work, left ventricular (LV) volumes and ejection fraction. Veno-occlusive unloading reduced infarct size compared with controls (Unloading 13.9 ± 8.2% versus Control 22.4 ± 6.6%; p = 0.04). Unloading increased myocardial salvage (54.8 ± 23.4% vs 28.5 ± 14.0%; p = 0.02), while the area at risk was similar (28.4 ± 6.7% vs 27.4 ± 5.8%; p = 0.74). LV ejection fraction was preserved in the unloaded group, while the control group showed a reduced LV ejection fraction. Veno-occlusive unloading reduced myocardial infarct size and preserved LV ejection fraction in an experimental acute ischemia–reperfusion model. This proof-of-concept study demonstrated the potential of veno-occlusive unloading as an adjunctive cardioprotective therapy in patients undergoing revascularization for acute myocardial infarction.
Physical characterization of biphasic bioceramic materials with different granulation sizes and their influence on bone repair and inflammation in rat calvaria
Authors: de Oliveira Junior Joviniano Martins , Montagner Pedro Giorgetti , Carrijo Rafael Coutinho , Martinez Elizabeth Ferreira 
Published: February 2021

AbstractBiphasic calcium phosphate bioceramics (BCP) consist of a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) within the same particle. Due to their osteoconductive properties, biocompatibility and resemblance to natural bone, these materials have become a promising and suitable alternative to autologous bone grafting. First, the topography characteristics, specific surface area, and total pore volume of BCP were evaluated using scanning electron microscopy and the BET and BJH methods. Next, this study aimed to evaluate the intensity of the inflammatory process and the bone neoformation capacity of various particle sizes of BCP in the repair of critical defects in the calvaria of rats. A xenogeneic biomaterial was used in the control group. After 30, 60, and 90 days, the animals were euthanized, followed by the processing of the samples to measure the intensity of inflammatory infiltrates and the areas of bone neoformation. Our results indicate that no considerable differences were observed in the inflammatory scores in sites treated with distinct BCP grain sizes. A greater area of bone neoformation was measured in the xenogeneic group at all analysis times, with no substantial differences in bone formation between the BCP particle size in the range of 250–500 µm and 500–1000 µm.
China’s first step towards probing the expanding universe and the nature of gravity using a space borne gravitational wave antenna
Authors:   The Taiji Scientific Collaboration, Wu Yue-Liang , Luo Zi-Ren , Wang Jian-Yu , Bai Meng , Bian Wei , Cai Rong-Gen , Cai Zhi-Ming , Cao Jin , Chen Di-Jun , Chen Ling , Chen Li-Sheng , Chen Ming-Wei , Chen Wei-Biao , Chen Ze-Yi , Cong Lin-Xiao , Deng Jian-Feng , Dong Xiao-Long , Duan Li , Fan Sen-Quan , Fan Shou-Shan , Fang Chao , Fang Yuan , Feng Ke , Feng Pan , Feng Zhun , Gao Rui-Hong , Gao Run-Lian , Guo Zong-Kuan , He Jian-Wu , He Ji-Bo , Hou Xia , Hu Liang , Hu Wen-Rui , Hu Zhi-Qiang , Huang Min-Jie , Jia Jian-Jun , Jiang Kai-Li , Jin Gang , Jin Hong-Bo , Kang Qi , Lei Jun-Gang , Li Bo-Quan , Li Dong-Jing , Li Fan , Li Hao-Si , Li Hua-Wang , Li Liu-Feng , Li Wei , Li Xiao-Kang , Li Ying-Min , Li Yong-Gui , Li Yun-Peng , Li Yu-Peng , Li Zhe , Lin Zhi-Yong , Liu Chang , Liu Dong-Bin , Liu He-Shan , Liu Hong , Liu Peng , Liu Yu-Rong , Lu Zong-Yu , Luo Hong-Wei , Ma Fu-Li , Ma Long-Fei , Ma Xiao-Shan , Ma Xin , Man Yi-Chuan , Min Jian , Niu Yu , Peng Jian-Kang , Peng Xiao-Dong , Qi Ke-Qi , Qiang Li-É , Qiao Cong-Feng , Qu Ye-Xi , Ruan Wen-Hong , Sha Wei , Shen Jia , Shi Xing-Jian , Shu Rong , Su Ju , Sui Yan-Lin , Sun Guang-Wei , Tang Wen-Lin , Tao Hong-Jiang , Tao Wen-Ze , Tian Zheng , Wan Ling-Feng , Wang Chen-Yu , Wang Jia , Wang Juan , Wang Lin-Lin , Wang Shao-Xin , Wang Xiao-Peng , Wang Yu-Kun , Wang Zhi , Wang Zuo-Lei , Wei Yu-Xiao , Di Wu  , Wu Li-Ming , Wu Peng-Zhan , Wu Zhi-Hua , Xi Dong-Xue , Xie Yi-Fang , Xin Guo-Feng , Xu Lu-Xiang , Xu Peng , Xu Shu-Yan , Xu Yu , Xue Sen-Wen , Xue Zhang-Bin , Yang Chao , Yang Ran , Yang Shi-Jia , Yang Shuang , Yang Yong , Yang Zhong-Guo , Yin Yong-Li , Yu Jin-Pei , Yu Tao , Zhang Ài-Bing , Zhang Chu , Zhang Min , Zhang Xue-Quan , Zhang Yuan-Zhong , Zhao Jian , Zhao Wei-Wei , Zhao Ya , Zheng Jian-Hua , Zhou Cui-Yun , Zhu Zhen-Cai , Zou Xiao-Bo , Zou Zi-Ming 
Published: February 2021

AbstractIn this perspective, we outline that a space borne gravitational wave detector network combining LISA and Taiji can be used to measure the Hubble constant with an uncertainty less than 0.5% in ten years, compared with the network of the ground based gravitational wave detectors which can measure the Hubble constant within a 2% uncertainty in the next five years by the standard siren method. Taiji is a Chinese space borne gravitational wave detection mission planned for launch in the early 2030 s. The pilot satellite mission Taiji-1 has been launched in August 2019 to verify the feasibility of Taiji. The results of a few technologies tested on Taiji-1 are presented in this paper.
Nondestructive microwave detection of a coherent quantum dynamics in cold atoms
Authors: Dubosclard William , Kim Seungjin , Garrido Alzar Carlos L. 
Published: February 2021

AbstractCold atom quantum sensors based on atom interferometry are among the most accurate instruments used in fundamental physics, metrology, and foreseen for autonomous inertial navigation. However, they typically have optically complex, cumbersome, and low-bandwidth atom detection systems, limiting their practical applications. Here, we demonstrate an enabling technology for high-bandwidth, compact, and nondestructive detection of cold atoms, using microwave radiation. We measure the reflected microwave signal to coherently and distinctly detect the population of single quantum states with a bandwidth close to 30 kHz and a design destructivity that we set to 0.04%. We use a horn antenna and free-falling molasses cooled atoms in order to demonstrate the feasibility of this technique in conventional cold atom interferometers. This technology, combined with coplanar waveguides used as microwave sources, provides a basic design building block for detection in future atom chip-based compact quantum inertial sensors.
Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor
Authors: Fu Ziwei , Wang Fei , Liu Xiyang , Hu Jiajia , Su Jiahui , Lu Xiaohan , Lu Aihua , Cho Jae Min , Symons J. David , Zou Chang-Jiang , Yang Tianxin 
Published: February 2021

Abstract
Until now, renin–angiotensin system (RAS) hyperactivity was largely thought to result from angiotensin II (Ang II)-dependent stimulation of the Ang II type 1 receptor (AT1R). Here we assessed the role of soluble (pro)renin receptor (sPRR), a product of site-1 protease-mediated cleavage of (pro)renin receptor (PRR), as a possible ligand of the AT1R in mediating: (i) endothelial cell dysfunction in vitro and (ii) arterial dysfunction in mice with diet-induced obesity. Primary human umbilical vein endothelial cells (HUVECs) treated with a recombinant histidine-tagged sPRR (sPRR-His) exhibited IκBα degradation concurrent with NF-κB p65 activation. These responses were secondary to sPRR-His evoked elevations in Nox4-derived H2O2 production that resulted in inflammation, apoptosis and reduced NO production. Each of these sPRR-His-evoked responses was attenuated by AT1R inhibition using Losartan (Los) but not ACE inhibition using captopril (Cap). Further mechanistic exploration revealed that sPRR-His activated AT1R downstream Gq signaling pathway. Immunoprecipitation coupled with autoradiography experiments and radioactive ligand competitive binding assays indicate sPRR directly interacts with AT1R via Lysine199 and Asparagine295. Important translational relevance was provided by findings from obese C57/BL6 mice that sPRR-His evoked endothelial dysfunction was sensitive to Los. Besides, sPRR-His elevated blood pressure in obese C57/BL6 mice, an effect that was reversed by concurrent treatment with Los but not Cap. Collectively, we provide solid evidence that the AT1R mediates the functions of sPRR during obesity-related hypertension. Inhibiting sPRR signaling should be considered further as a potential therapeutic intervention in the treatment and prevention of cardiovascular disorders involving elevated blood pressure.
Time‐phased electricity package design for electricity retailers considering bounded rationality of consumers
Authors: Zhang Zhi , Lin Zhenzhi , Wen Fushuan , Yang Li , Xue Yusheng 
Published: February 2021

AbstractThe ever‐increasing competition in electricity retail markets has become one of the pivotal causes for electricity retailers to provide attractive packages to consumers for enhancing their market shares. Based on the current user‐side time‐of‐use electricity price mechanism in China, a bi‐level optimization model for designing a time‐phased and quantity‐incentive electricity package is proposed for electricity retailers considering bounded rationality of consumers. In the upper‐level model, the optimization objective is to maximize the electricity purchase and sale revenue of a specified retailer. In the lower‐level model, consumers are modelled as bounded rational decision‐makers whose objective is to purchase the electricity package with the highest value, considering the value of the excess electricity of the package. In addition, consumer psychology theory is introduced to describe the bounded rational responses of consumers to electricity packages. Simulations based on data of residential consumers in a city of China illustrate that by properly determining package quotas in different time periods, electricity retailers can guide consumers to change consumption time and volume, and hence, increase their revenues by increasing trading volume or reducing electricity procurement costs in forward bilateral transactions and spot markets.
Automated classification system for drowsiness detection using convolutional neural network and electroencephalogram
Authors: Balam Venkata Phanikrishna , Sameer Venkata Udaya , Chinara Suchismitha 
Published: February 2021

AbstractDetecting drowsiness in drivers while driving is extremely important to avoid possible accidents and reduce the fatality rate due to drivers sleeping at the wheel. A real‐time alert generation when the driver might possibly go into sleepy state is essential to safeguard any unwarranted incidents. Wearable sensors to monitor vehicle movement and camera‐based systems to monitor driver behaviour are commonly used to detect driver drowsiness. Due to the fact that electroencephalogram (EEG) signals have the ability to monitor the mood of humans and are easily obtainable, many different EEG‐based drowsiness detection systems have been proposed to date. In this study, a novel deep learning architecture based on a convolutional neural network (CNN) is proposed for automated drowsiness detection using a single‐channel EEG signal. To improve the generalization performance of the proposed method, subject‐wise, cross‐subject‐wise, and combined‐subjects‐wise validations have been employed. The whole of the work is carried over pre‐recorded sleep state EEG data obtained from benchmarked dataset. The experimental results show a superior detection capability compared to the existing state–of–the–art drowsiness detection methods using single‐channel EEG signals.
New low-mass members of Chamaeleon I and ϵ Cha
Authors: Kubiak K. , Mužić K. , Sousa I. , Almendros-Abad V. , Köhler R. , Scholz A. 
Published: February 2021

Aims. The goal of this paper is to increase the membership list of the Chamaeleon star-forming region and the ϵ Cha moving group, in particular for low-mass stars and substellar objects. We extended the search region significantly beyond the dark clouds.
Methods. Our sample has been selected based on proper motions and colours obtained from Gaia and 2MASS. We present and discuss the optical spectroscopic follow-up of 18 low-mass stellar objects in Cha I and ϵ Cha. We characterize the properties of objects by deriving their physical parameters from spectroscopy and photometry.
Results. We add three more low-mass members to the list of Cha I and increase the census of known ϵ Cha members by more than 40%, thereby spectroscopically confirming 13 new members and relying on X-ray emission as youth indicator for 2 more. In most cases the best-fitting spectral template is from objects in the TW Hya association, indicating that ϵ Cha has a similar age. The first estimate of the slope of the initial mass function in ϵ Cha down to the substellar regime is consistent with that of other young clusters. We estimate our initial mass function (IMF) to be complete down to ≈0.03 M⊙. The IMF can be represented by two power laws: for M < 0.5 M⊙ α = 0.42 ± 0.11 and for M > 0.5 M⊙ α = 1.44 ± 0.12.
Conclusions. We find similarities between ϵ Cha and the southernmost part of Lower Centaurus Crux (LCC A0), which lie at similar distances and share the same proper motions. This suggests that ϵ Cha and LCC A0 may have been born during the same star formation event
Exploring the radial evolution of interplanetary coronal mass ejections using EUHFORIA
Authors: Scolini C. , Dasso S. , Rodriguez L. , Zhukov A. N. , Poedts S. 
Published: February 2021

Context. Coronal mass ejections (CMEs) are large-scale eruptions coming from the Sun and transiting into interplanetary space. While it is widely known that they are major drivers of space weather, further knowledge of CME properties in the inner heliosphere is limited by the scarcity of observations at heliocentric distances other than 1 au. In addition, most CMEs are observed in situ by a single spacecraft and in-depth studies require numerical models to complement the few available observations.
Aims. We aim to assess the ability of the linear force-free spheromak CME model of the EUropean Heliospheric FORecasting Information Asset (EUHFORIA) to describe the radial evolution of interplanetary CMEs in order to yield new contexts for observational studies.
Methods. We modelled one well-studied CME with EUHFORIA, investigating its radial evolution by placing virtual spacecraft along the Sun–Earth line in the simulation domain. To directly compare observational and modelling results, we characterised the interplanetary CME signatures between 0.2 and 1.9 au from modelled time series, exploiting techniques that are traditionally employed to analyse real in situ data.
Results. Our results show that the modelled radial evolution of the mean solar wind and CME values is consistent with the observational and theoretical expectations. The CME expands as a consequence of the decaying pressure in the surrounding solar wind: the expansion is rapid within 0.4 au and moderate at larger distances. The early rapid expansion was not sufficient to explain the overestimated CME radial size in our simulation, suggesting this is an intrinsic limitation of the spheromak geometry applied in this case. The magnetic field profile indicates a relaxation on the part of the CME structure during propagation, while CME ageing is most probably not a substantial source of magnetic asymmetry beyond 0.4 au. Finally, we report a CME wake that is significantly shorter than what has been suggested by observations.
Conclusions. Overall, EUHFORIA provides a consistent description of the radial evolution of solar wind and CMEs, at least close to their centres. Nevertheless, improvements are required to better reproduce the CME radial extension.
Inactivation of Herpes Simplex Virus by Photosensitizing Anthraquinones Isolated from Heterophyllaea pustulata
Authors: Mugas M. Laura , Marioni Juliana , Martinez Florencia , Aguilar Juan J. , Cabrera José L. , Contigiani Marta S. , Konigheim Brenda S. , Núñez-Montoya Susana C. 
Published: February 2021

Abstract
Heterophyllaea pustulata is a phototoxic plant from Argentina. Aerial parts extracts, high in photosensitizing anthraquinones, have shown in vitro antiviral activity. The purpose of this study was to study the antiherpetic activity of the main purified anthraquinones, even evaluating their competence as photodynamic sensitizers to photo-stimulate the antiviral effect. In vitro antiviral activity against Herpes Simplex virus type I and the photo-inactivation of viral particle were studied by the Neutral Red uptake test and observation of the cytopathic effect. Rubiadin 1-methyl ether and 5,5′-bisoranjidiol produced a significant effect (≥ 80% inhibition) with minimal damage to host cells (subtoxic concentration). Anthraquinones with poor antiherpetic activity at its maximum noncytotoxic concentration showed an important photo-stimulated effect, such is the case of soranjidiol and 5,5′-bisoranjidiol (28.0 ± 6.3 vs. 81.8 ± 2.1% and 15.5 ± 0.3
vs. 89.8 ± 1.7%, respectively). The study also proved the decrease of viral particles, necessary to reduce infection. Therefore, photosensitizing anthraquinones from natural resources could be proposed to develop new treatments for localized viral lesions with antimicrobial photodynamic therapy.
Poststationäre Weiterbehandlung von Patienten mit ICD-Diagnosen F3 und F4 in Psychiatrie und Psychosomatik (PfAD-Studie)
Authors: Bichescu-Burian Dana , Jaeger Susanne , Steinert Tilman , Uhlmann Carmen , Flammer Erich 
Published: February 2021

Zusammenfassung
Ziel Untersuchung poststationärer Behandlungswege und ihrer Prädiktoren.
Methode In einer prospektiven naturalistischen Studie wurden 320 Erwachsene, die in 4 stationären Settings behandelt wurden, bei Aufnahme, Entlassung und zu 2 Nachbeobachtungszeitpunkten untersucht. Mit standardisierten Instrumenten wurden soziodemografische und klinische Daten sowie Wege im Versorgungssystem im Halbjahr vor und im Jahr nach der Indexbehandlung erhoben. Deskriptive Analysen und logistische Regressionsmodelle wurden angewandt.
Ergebnisse Stationäre Behandlungen nach Entlassung aus der Indexbehandlung waren mehrheitlich geplante Weiterbehandlungen. Fast alle Patienten wurden ambulant nachbehandelt. Hauptprädiktoren für stationäre Behandlung nach Indexbehandlung und für ambulante Psychotherapie waren das Index-Setting (Psychiatrie/Psychosomatik) sowie vorbestehende und geplante Behandlungen.
Schlussfolgerung Die Behandlungswege in Psychiatrie und Psychosomatik entsprechen der vorgegebenen Indikation, verlaufen aber meist getrennt voneinander und zeigen wenig Überschneidung.
1-Year Evaluation of OT Bridge Abutments for Immediately Loaded Maxillary Fixed Restorations: A Multicenter Study
Authors: Acampora Rosario , Montanari Marco , Scrascia Roberto , Ferrari Emiliano , Pasi Massimo , Cervino Gabriele , Meloni Silvio Mario , Lumbau Aurea Immacolata , Xhanari Erta , Koshovari Alba , Tallarico Marco 
Published: February 2021

Abstract

Objective  Preliminary data on survival and success rates of immediately loaded, maxillary, screw-retained, implant-supported, fixed restorations delivered on narrow and low-profile OT Equator abutments (OT Bridge, Rhein’83) were evaluated.
Materials and Methods This retrospective study evaluated data collected from patients rehabilitated with OT Bridge prosthetic concept between November 2017 and February 2019 in six different centers. Outcome measures were implant and prosthetic survival rates, biological and technical complications, marginal bone loss (MBL), oral health impact profile (OHIP), bleeding on probing, and plaque index.
Results A total of 76 implants were inserted in 14 patients. Patients were followed for a mean period of 15.8 months (range = 12–24). All the patients receive OT Equator (Rhein'83) as intermediate abutments. One year after loading, one implant failed (1.3%). None of the prosthesis failed. One prosthetic complication was experienced in one patient. Three out of 76 implants were connected to the prosthetic framework using only the Seeger system, without screw. Difference in OHIP values was statistically significant (71.9 ± 8.5; p = 0.000). One year after loading, MBL was 0.21 ± 0.11 mm and p-value was 0.000. One year after loading, 8.7% of the examined implant sites present positive bleeding on probing, while 6.4% of the implant sites presented plaque.
Conclusion The OT Equator abutments (Rhein'83) showed successful results when used to support maxillary fixed dental prosthesis delivered on four to six implants. High implant and prosthetic survival rates, very low complications, high patient satisfaction, and good biological parameters, including only 0.2 mm of bone remodeling were experienced one year after function. Further studies are needed to confirm these preliminary results.
Evaluation and Medical Management of Uncomplicated Diverticulitis
Authors: Langenfeld Sean J. 
Published: February 2021

AbstractUncomplicated diverticulitis is common, and its evaluation and treatment have evolved over time. Most patients present in a nontoxic manner with localized pain, leukocytosis, and reliable findings on computed tomography (CT). Healthy and stable patients are typically treated in the outpatient setting with very high rates of success. Recently, the necessity of antibiotic therapy has come into question, and several alternative agents have emerged, with the jury still out on their relative roles in diverticular disease. Currently, colonoscopy is still recommended after the resolution of an index episode of uncomplicated diverticulitis, and recurrence rates remain low. Several diet and lifestyle modifications have been shown to impact the rates of diverticulitis recurrence.
Management of Traumatic Cervical Spondyloptosis
Authors: Rai Hitesh Inder Singh , Garg Kanwaljeet , Agrawal Deepak 
Published: February 2021

AbstractTraumatic cervical spondyloptosis is a 3-column fracture-dislocation resulting in a highly unstable spine requiring urgent reduction, stabilization, and fixation. Since its occurrence is not that common, there are a lot of controversies concerning its management. A holistic approach has been proposed regarding the management of traumatic cervical spondyloptosis.