bluuebunny/crossref_metadata_2025_split huggingface dataset:
AI enabled sign language recognition and VR space bidirectional communication using triboelectric smart glove
Authors: Wen Feng , Zhang Zixuan , He Tianyiyi , Lee Chengkuo 
Published: September 2021

AbstractSign language recognition, especially the sentence recognition, is of great significance for lowering the communication barrier between the hearing/speech impaired and the non-signers. The general glove solutions, which are employed to detect motions of our dexterous hands, only achieve recognizing discrete single gestures (i.e., numbers, letters, or words) instead of sentences, far from satisfying the meet of the signers’ daily communication. Here, we propose an artificial intelligence enabled sign language recognition and communication system comprising sensing gloves, deep learning block, and virtual reality interface. Non-segmentation and segmentation assisted deep learning model achieves the recognition of 50 words and 20 sentences. Significantly, the segmentation approach splits entire sentence signals into word units. Then the deep learning model recognizes all word elements and reversely reconstructs and recognizes sentences. Furthermore, new/never-seen sentences created by new-order word elements recombination can be recognized with an average correct rate of 86.67%. Finally, the sign language recognition results are projected into virtual space and translated into text and audio, allowing the remote and bidirectional communication between signers and non-signers.
Selective deoxygenative alkylation of alcohols via photocatalytic domino radical fragmentations
Authors: Guo Hong-Mei , Wu Xuesong 
Published: September 2021

AbstractThe delivery of alkyl radicals through photocatalytic deoxygenation of primary alcohols under mild conditions is a so far unmet challenge. In this report, we present a one-pot strategy for deoxygenative Giese reaction of alcohols with electron-deficient alkenes, by using xanthate salts as alcohol-activating groups for radical generation under visible-light photoredox conditions in the presence of triphenylphosphine. The convenient generation of xanthate salts and high reactivity of sequential C–S/C–O bond homolytic cleavage enable efficient deoxygenation of primary, secondary and tertiary alcohols with diverse functionality and structure to generate the corresponding alkyl radicals, including methyl radical. Moreover, chemoselective radical monodeoxygenation of diols is achieved via selective formation of xanthate salts.
Impact of global cooling on Early Cretaceous high pCO2 world during the Weissert Event
Authors: Cavalheiro Liyenne , Wagner Thomas , Steinig Sebastian , Bottini Cinzia , Dummann Wolf , Esegbue Onoriode , Gambacorta Gabriele , Giraldo-Gómez Victor , Farnsworth Alexander , Flögel Sascha , Hofmann Peter , Lunt Daniel J. , Rethemeyer Janet , Torricelli Stefano , Erba Elisabetta 
Published: September 2021

AbstractThe Weissert Event ~133 million years ago marked a profound global cooling that punctuated the Early Cretaceous greenhouse. We present modelling, high-resolution bulk organic carbon isotopes and chronostratigraphically calibrated sea surface temperature (SSTs) based on an organic paleothermometer (the TEX86 proxy), which capture the Weissert Event in the semi-enclosed Weddell Sea basin, offshore Antarctica (paleolatitude ~54 °S; paleowater depth ~500 meters). We document a ~3–4 °C drop in SST coinciding with the Weissert cold end, and converge the Weddell Sea data, climate simulations and available worldwide multi-proxy based temperature data towards one unifying solution providing a best-fit between all lines of evidence. The outcome confirms a 3.0 °C ( ±1.7 °C) global mean surface cooling across the Weissert Event, which translates into a ~40% drop in atmospheric pCO2 over a period of ~700 thousand years. Consistent with geologic evidence, this pCO2 drop favoured the potential build-up of local polar ice.
CryoEM structure of the super-constricted two-start dynamin 1 filament
Authors: Liu Jiwei , Alvarez Frances Joan D. , Clare Daniel K. , Noel Jeffrey K. , Zhang Peijun 
Published: September 2021

AbstractDynamin belongs to the large GTPase superfamily, and mediates the fission of vesicles during endocytosis. Dynamin molecules are recruited to the neck of budding vesicles to assemble into a helical collar and to constrict the underlying membrane. Two helical forms were observed: the one-start helix in the constricted state and the two-start helix in the super-constricted state. Here we report the cryoEM structure of a super-constricted two-start dynamin 1 filament at 3.74 Å resolution. The two strands are joined by the conserved GTPase dimeric interface. In comparison with the one-start structure, a rotation around Hinge 1 is observed, essential for communicating the chemical power of the GTPase domain and the mechanical force of the Stalk and PH domain onto the underlying membrane. The Stalk interfaces are well conserved and serve as fulcrums for adapting to changing curvatures. Relative to one-start, small rotations per interface accumulate to bring a drastic change in the helical pitch. Elasticity theory rationalizes the diversity of dynamin helical symmetries and suggests corresponding functional significance.
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
Authors: Dutta Debashis , Jana Malabendu , Majumder Moumita , Mondal Susanta , Roy Avik , Pahan Kalipada 
Published: September 2021

AbstractPathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) are unclear. Here, we show that preformed α-syn fibrils (PFF) increase the association between TLR2 and MyD88, resulting in microglial activation. The TLR2-interaction domain of MyD88 (wtTIDM) peptide-mediated selective inhibition of TLR2 reduces PFF-induced microglial inflammation in vitro. In PFF-seeded A53T mice, the nasal administration of the wtTIDM peptide, NEMO-binding domain (wtNBD) peptide, or genetic deletion of TLR2 reduces glial inflammation, decreases α-syn spreading, and protects dopaminergic neurons by inhibiting NF-κB. In summary, α-syn spreading depends on the TLR2/MyD88/NF-κB pathway and it can be reduced by nasal delivery of wtTIDM and wtNBD peptides.
Tissue-agnostic drug approvals: how does this apply to patients with breast cancer?
Authors: Weis Luiza N. , Tolaney Sara M. , Barrios Carlos H. , Barroso-Sousa Romualdo 
Published: September 2021

AbstractPrecision medicine has provided new perspectives in oncology, yielding research on the use of targeted therapies across different tumor types, regardless of their site of origin, a concept known as tissue-agnostic indication. Since 2017, the Food and Drug Administration (FDA) has approved the use of three different agents for tumor-agnostic treatment: pembrolizumab (for patients with microsatellite instability or high tumor mutational burden) and larotrectinib and entrectinib (both for use in patients harboring tumors withNTRKfusions). Importantly, the genomic alterations targeted by these agents are uncommon or rare in breast cancer, and little information exists regarding their efficacy in advanced breast cancer. In this review, we discuss the prevalence of these targets in breast cancer, their detection methods, the clinical characteristics of patients whose tumors have these alterations, and available data regarding the efficacy of these agents in breast cancer.
Properties of poly (vinyl chloride) membranes containing cadmium pigments, irradiated with UV radiation
Authors: Tworek Magdalena , Skowroński Łukasz , Makarewicz Edwin , Kowalik Joanna 
Published: September 2021

AbstractThe cadmium pigments were yellow, orange and red pigments. They consisted of cadmium sulphide and cadmium sulphide with zinc sulphide as well as cadmium sulphide with cadmium selenide. Their quantitative composition and specific surface area were examined. The pigments were used to color the poly (vinyl chloride) plastisol films, which were then exposed to UV radiation. The surfaces of the coloured membranes were examined by infrared spectroscopy before and after irradiation with UV. The changes occurred in the PVC membrane were investigated by thermogravimetric analysis. The degree of crystallinity of the pigments and the membrane was determined by X-ray diffraction. The color change of the membranes was determined from the spectra obtained by reflection spectroscopy, and the components of colour L*, a* and b* were calculated. Base of them, the tolerance of colour deviations (ΔE*) was determined. The calculations allowed for the determination of the effect of UV irradiation on the change of the colour of the membranes and confirmation of the degradation of the pigments and polymer membrane.
Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica
Authors: Dwivedi Vivek Dhar , Singh Ankita , El-Kafraway Sherif Aly , Alandijany Thamir A. , Faizo Arwa A. , Bajrai Leena Hussein , Kamal Mohammad Amjad , Azhar Esam Ibraheem 
Published: September 2021

AbstractJapanese encephalitis (JE) virus is a flavivirus causing encephalitis causing neurological damage. RNA-dependent-RNA-polymerase (RdRp) is responsible for genome replication making it excellent anti-viral target. In this study, the crystal structure of JE RdRp (jRdRp) and bioflavonoids reported in Azadirachta indica were retrieved from specific databases. Structure-based virtual screening was employed using MTiOpenScreen server and top four compounds selected with the most negative docking scores. Conformations were redocked using AutoDock Vina; these complexes showed mechanistic interactions with Arg474, Gly605, Asp668, and Trp800 residues in the active site of jRdRp, i.e., guanosine-5′-triphosphate. Furthermore, 100 ns classical molecular dynamics simulation and binding free energy calculation showed stability of docked bioflavonoids in the active jRdRp pocket and significant contribution of van-der-Waals interactions for docked complex stability during simulation. Therefore, this study predicted the anti-viral activity of Gedunin, Nimbolide, Ohchinin acetate, and Kulactone against jRdRp and can be considered for further antiviral drug development.
Highly conductive electronics circuits from aerosol jet printed silver inks
Authors: Skarżyński Kacper , Krzemiński Jakub , Jakubowska Małgorzata , Słoma Marcin 
Published: September 2021

AbstractRecently, low-cost electronics printed on lightweight, flexible and 3D shaped substrates are gaining importance in the markets of wearables and smart packaging. However, printed electronics do not meet the electrical performance of subtractive techniques because the resistivity of metallic printed patterns is still much higher than that of bulk material. To fulfil this need, low-resistive and easy printable inks for high resolution printed electronics techniques are needed. In this work, parameters of silver nanoparticles ink for micro-scale printed electronics technique, Aerosol Jet Printing, are being enhanced. To increase electrical conductivity and enhance printability, surfactants and dispersing agents were used to increase ultrasonic atomisation efficiency, obtain a uniform structure of printed lines, and narrow the width of printed patterns. Electrical measurements show a decrease in resistivity value in samples enhanced by cationic and non-ionic surfactants, by 95%, compared to initially prepared inks. Surfactant additions to silver nanoparticles Aerosol Jet Printing ink show promising features for application in modern electronics.
Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias
Authors: Kim Yun Gi , Choi Yun Young , Han Kyung-Do , Min Kyongjin , Choi Ha Young , Shim Jaemin , Choi Jong-Il , Kim Young-Hoon 
Published: September 2021

AbstractAtrial fibrillation (AF) is associated with various major adverse cardiac events such as ischemic stroke, heart failure, and increased overall mortality. However, its association with lethal ventricular arrhythmias such as ventricular tachycardia (VT), ventricular flutter (VFL), and ventricular fibrillation (VF) is controversial. We conducted this study to determine whether AF can increase the risk of VT, VFL, and VF. We utilized the Korean National Health Insurance Service database for this nationwide population-based study. This study enrolled people who underwent a nationwide health screen in 2009 for whom clinical follow-up data were available until December 2018. Primary outcome endpoint was the occurrence of VT, VFL, or VF in people who were and were not diagnosed with new-onset AF in 2009. We analyzed a total of 9,751,705 people. In 2009, 12,689 people were diagnosed with new-onset AF (AF group). The incidence (events per 1000 person-years of follow-up) of VT, VFL, and VF was 2.472 and 0.282 in the AF and non-AF groups, respectively. After adjustment for covariates, new-onset AF was associated with 4.6-fold increased risk (p < 0.001) of VT, VFL, and VF over 10 years of follow-up. The risk of VT, VFL, and VF was even higher if identification of AF was based on intensified criteria (≥ 2 outpatient records or ≥ 1 inpatient record; hazard ratio = 5.221; p < 0.001). In conclusion, the incidence of VT, VFL, and VF was significantly increased in people with new-onset AF. The potential risk of suffering lethal ventricular arrhythmia in people with AF should be considered in clinical practice.
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
Authors: Vilela Raquel , Huebner Marianne , Vilela Camila , Vilela Gabriella , Pettersen Bruno , Oliveira Claudia , Mendoza Leonel 
Published: September 2021

AbstractEver since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies. This pathogen infects the skin of humans and as long believed, dolphin skin. However, recent DNA analyses of infected dolphins placed its DNA sequences within Paracoccidioides species. This came as a surprise and suggested the human and dolphin pathogens may be different species. In this study, population genetic analyses of DNA from four infected dolphins grouped this pathogen in a monophyletic cluster sister to P. americana and to the other Paracoccidioides species. Based on the results we have emended the taxonomy of the dolphin pathogen as Paracoccidioides cetii and P. loboi the one infecting human. Our data warn that phylogenetic analysis of available taxa without the inclusion of unusual members may provide incomplete information for the accurate classification of anomalous species.
The effects of heterogeneous mechanical properties on the response of a ductile material
Authors: Song Yichi , Schiffer Andreas , Tagarielli Vito L. 
Published: September 2021

AbstractWe investigate numerically the small-strain, elastic–plastic response of statistically isotropic materials with non-uniform spatial distributions of mechanical properties. The numerical predictions are compared to simple bounds derived analytically. We explore systematically the effects of heterogeneity on the macroscopic stiffness, strength, asymmetry, stability and size dependence. Monte Carlo analyses of the response of statistical volume elements are conducted at different strain triaxiality using computational homogenisation, and allow exploring the macroscopic yield behaviour of the heterogeneous material. We illustrate quantitatively how the pressure-sensitivity of the yield surface of the solid increases with heterogeneity in the elastic response. We use the simple analytical models developed here to derive an approximate scaling law linking the fatigue endurance threshold of metallic alloys to their stiffness, yield strength and tensile strength.
Grading of endometrial cancer using 1H HR-MAS NMR-based metabolomics
Authors: Skorupa Agnieszka , Poński Michał , Ciszek Mateusz , Cichoń Bartosz , Klimek Mateusz , Witek Andrzej , Pakuło Sławomir , Boguszewicz Łukasz , Sokół Maria 
Published: September 2021

AbstractThe tissue metabolomic characteristics associated with endometrial cancer (EC) at different grades were studied using high resolution (400 MHz) magic angle spinning (HR-MAS) proton spectroscopy. The metabolic profiles were obtained from 64 patients (14 with grade 1 (G1), 33 with grade 2 (G2) and 17 with grade 3 (G3) tumors) and compared with the profile acquired from 10 patients with the benign disorders. OPLS-DA revealed increased valine, isoleucine, leucine, hypotaurine, serine, lysine, ethanolamine, choline and decreased creatine, creatinine, glutathione, ascorbate, glutamate, phosphoethanolamine and scyllo-inositol in all EC grades in reference to the non-transformed tissue. The increased levels of taurine was additionally detected in the G1 and G2 tumors in comparison to the control tissue, while the elevated glycine, N-acetyl compound and lactate—in the G1 and G3 tumors. The metabolic features typical for the G1 tumors are the increased dimethyl sulfone, phosphocholine, and decreased glycerophosphocholine and glutamine levels, while the decreased myo-inositol level is characteristic for the G2 and G3 tumors. The elevated 3-hydroxybutyrate, alanine and betaine levels were observed in the G3 tumors. The differences between the grade G1 and G3 malignances were mainly related to the perturbations of phosphoethanolamine and phosphocholine biosynthesis, inositol, betaine, serine and glycine metabolism. The statistical significance of the OPLS-DA modeling was also verified by an univariate analysis. HR-MAS NMR based metabolomics provides an useful insight into the metabolic reprogramming in endometrial cancer.
1/x power-law in a close proximity of the Bak–Tang–Wiesenfeld sandpile
Authors: Shapoval Alexander , Shapoval Boris , Shnirman Mikhail 
Published: September 2021

AbstractA cellular automaton constructed by Bak, Tang, and Wiesenfeld (BTW) in 1987 to explain the 1/f noise was recognized by the community for the theoretical foundations of self-organized criticality (SOC). Their conceptual work gave rise to various scientific areas in statistical physics, mathematics, and applied fields. The BTW core principles are based on steady slow loading and an instant huge stress-release. Advanced models, extensively developed far beyond the foundations for 34 years to successfully explain SOC in real-life processes, still failed to generate truncated 1/x probability distributions. This is done here through returning to the original BTW model and establishing its larger potential than the state-of-the-art expects. We establish that clustering of the events in space and time together with the core principles revealed by BTW lead to approximately 1/x power-law in the size-frequency distribution of model events.
Energy homeostasis deregulation is attenuated by TUDCA treatment in streptozotocin-induced Alzheimer’s disease mice model
Authors: Zangerolamo Lucas , Solon Carina , Soares Gabriela M. , Engel Daiane F. , Velloso Licio A. , Boschero Antonio C. , Carneiro Everardo M. , Barbosa Helena Cristina L. 
Published: September 2021

AbstractAlzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. While cognitive deficits remain the major manifestation of AD, metabolic and non-cognitive abnormalities, such as alterations in food intake, body weight and energy balance are also present, both in AD patients and animal models. In this sense, the tauroursodeoxycholic acid (TUDCA) has shown beneficial effects both in reducing the central and cognitive markers of AD, as well as in attenuating the metabolic disorders associated with it. We previously demonstrated that TUDCA improves glucose homeostasis and decreases the main AD neuromarkers in the streptozotocin-induced AD mouse model (Stz). Besides that, TUDCA-treated Stz mice showed lower body weight and adiposity. Here, we investigated the actions of TUDCA involved in the regulation of body weight and adiposity in Stz mice, since the effects of TUDCA in hypothalamic appetite control and energy homeostasis have not yet been explored in an AD mice model. The TUDCA-treated mice (Stz + TUDCA) displayed lower food intake, higher energy expenditure (EE) and respiratory quotient. In addition, we observed in the hypothalamus of the Stz + TUDCA mice reduced fluorescence and gene expression of inflammatory markers, as well as normalization of the orexigenic neuropeptides AgRP and NPY expression. Moreover, leptin-induced p-JAK2 and p-STAT3 signaling in the hypothalamus of Stz + TUDCA mice was improved, accompanied by reduced acute food intake after leptin stimulation. Taken together, we demonstrate that TUDCA treatment restores energy metabolism in Stz mice, a phenomenon that is associated with reduced food intake, increased EE and improved hypothalamic leptin signaling. These findings suggest treatment with TUDCA as a promising therapeutic intervention for the control of energy homeostasis in AD individuals.
Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis
Authors: Mirna Moritz , Schmutzler Lukas , Topf Albert , Hoppe Uta C. , Lichtenauer Michael 
Published: September 2021

AbstractNeutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are associated with the severity of various diseases. The aim of this study was to demonstrate the relationship of NLR and MLR with the severity of myocarditis. 202 consecutive patients with myocarditis were retrospectively enrolled in this study. Laboratory parameters and clinical data were extracted from hospital records and discharge letters. Median NLR was 2.48 (IQR 1.55–4.58) and median MLR was 0.42 (IQR 0.39–0.58). NLR and MLR correlated with HF, CRP and leukocyte count, MLR further correlated inversely with LV systolic function (rs = − 0.379, p = 0.030). Both ratios correlated better with length of hospital stay (NLR: rs = 0.435, p = 0.003; MLR: rs = 0.534, p < 0.0001) than CRP, leukocyte count, IL-6 or procalcitonin. AUCs for the prediction of prolonged hospital stay (NLR = 0.75, MLR = 0.80), and optimal cut-offs therefor were calculated. Patients who had in-hospital complications showed a higher NLR, however, this remained statistically insignificant. NLR and MLR correlated with the length of stay, as well as with several clinical and laboratory parameters in patients with myocarditis. Since white blood cell differentials are relatively easy and fast to perform, both ratios could facilitate further risk stratification in affected patients.