bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients with presumed tuberculosis in sub-Saharan Africa that are not diagnosed with tuberculosis: a systematic review and meta-analysis
Authors: Jayasooriya S , Dimambro-Denson F , Beecroft C , Balen J , Awokola B , Mitchell C , Kampmann B , Campbell F , Dodd PJ , Mortimer K 
Published: May 2021

AbstractBackgroundMany patients in sub-Saharan Africa whom a diagnosis of tuberculosis is considered are subsequently not diagnosed with tuberculosis. The proportion of patients this represents, and their alternative diagnoses, have not previously been systematically reviewed.MethodsWe searched four databases from inception to April 27, 2020, without language restrictions (PROSPERO: CRD42018100004). We included all adult pulmonary tuberculosis diagnostic studies from sub-Saharan Africa, excluding case series and inpatient studies. We extracted the proportion of patients with presumed tuberculosis subsequently not diagnosed with tuberculosis and any alternative diagnoses received. We conducted a random-effects meta-analysis to obtain pooled estimates stratified by passive and active case finding.ResultsOur search identified 1799 studies, of which 18 studies with 14527 participants from 10 African countries were included. The proportion of patients with presumed tuberculosis subsequently not diagnosed with tuberculosis was 48.5% (95% CI 38.4-56.7) in passive and 92.7% (95% CI 83.1-97.0) in active case finding studies. This proportion increased with declining numbers of clinically diagnosed tuberculosis cases. Past history of tuberculosis was documented in only 55% of studies, with just five out of 18 reporting any alternative diagnoses.DiscussionNearly half of all patients with presumed tuberculosis in sub-Saharan Africa do not have a final diagnosis of active tuberculosis. This proportion may be higher when active case finding strategies are used. Little is known about the healthcare needs of these patients. Research is required to better characterise these patient populations and plan health system solutions that meet their needs.FundingNIHR, UK MRC
A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis
Authors: Li Shulin , Yan Rui , Xu Jialu , Zhao Shiqun , Ma Xinyu , Sun Qiming , Zhang Min , Li Ying , Liu Jun-Jie Gogo , Chen Liangyi , Li Sai , Xu Ke , Ge Liang 
Published: May 2021

ABSTRACTUnder stress, the endomembrane system undergoes reorganization to support autophagosome biogenesis, which is a central step in autophagy. How the endomembrane system remodels has been poorly understood. Here we identify a new type of membrane contact formed between the ER-Golgi intermediate compartment (ERGIC) and the ER-exit site (ERES) in the ER-Golgi system, which is essential for promoting autophagosome biogenesis induced by different stress stimuli. The ERGIC-ERES contact is established by the interaction between TMED9 and SEC12 which generates a short distance opposition (as close as 2-5 nm) between the two compartments. The tight membrane contact allows the ERES-located SEC12 to transactivate COPII assembly on the ERGIC. In addition, a portion of SEC12 also relocates to the ERGIC. Through both mechanisms, the ERGIC-ERES contact promotes formation of the ERGIC-derived COPII vesicle, a membrane precursor of the autophagosome. The ERGIC-ERES contact is physically and functionally different from the TFG-mediated ERGIC-ERES adjunction involved in secretory protein transport, and therefore defines a unique endomembrane structure generated upon stress conditions for autophagic membrane formation.
Centrosome maturation requires phosphorylation-mediated sequential domain interactions of SPD-5
Authors: Nakajo Momoe , Kano Hikaru , Tsuyama Kenji , Haruta Nami , Sugimoto Asako 
Published: May 2021

AbstractCentrosomes consist of two centrioles and surrounding pericentriolar material (PCM). PCM expands during mitosis in a process called centrosome maturation, in which PCM scaffold proteins play pivotal roles to recruit other centrosomal proteins. In C. elegans, the scaffold protein SPD-5 forms PCM scaffold in a PLK-1 phosphorylation-dependent manner. However, how phosphorylation of SPD-5 promotes PCM scaffold assembly is unclear. Here, we identified three functional domains of SPD-5 through in vivo domain analyses, and propose that sequential domain interactions of SPD-5 are required for mitotic PCM scaffold assembly. Firstly, SPD-5 is targeted to centrioles through direct interaction between its centriole localization (CL) domain and a centriolar protein PCMD-1. Then, intra- and inter-molecular interaction between SPD-5 phospho-regulated multimerization (PReM) domain and the PReM association (PA) domain is triggered by phosphorylation by PLK-1, which leads to PCM scaffold expansion. Our findings suggest that the sequential domain interactions of scaffold proteins mediated by Polo/PLK-1 phosphorylation is an evolutionarily conserved mechanism of PCM scaffold assembly.
The strategic choice of contract types in business process outsourcing
Authors: Ge Ling , Wang Xiaoyan , Yang Zhilin 
Published: May 2021

PurposeHow to determine the appropriate contractual structure for an outsourcing relationship has been a major theme in the business process outsourcing (BPO) literature. Drawing on transaction cost economics, this study aims to examine how anticipated coordination and adaptation costs in a BPO relationship affect the choice of contract types. Specifically, this research categorizes contracts types (fixed-price, time and materials and hybrid contracts) based on levels of contract design comprehensiveness and flexibility to change.Design/methodology/approachThe research setting is the BPO for a focal firm, involving a contractor. Data from 153 US companies are collected using a structured questionnaire on senior executives of functional areas of marketing, IT and finance. Hypotheses were tested using ordered probit model.FindingsThe results show that maturity is negatively associated with anticipated adaptation costs, while modularity and IT detachability are negatively related to anticipated coordination costs. Furthermore, adaptation costs have a direct impact on the choice, whereas the anticipated coordination costs do not have a significant direct impact on contract choice. The strength of adaptation costs' impact, however, is significantly reduced when coordination costs are high.Originality/valueThis study explicitly examines the role of anticipated coordination and adaptation costs in shaping the strategic choice of contract types in the BPO market. By differentiating the two types of anticipated transaction costs, this research enables a better understanding of the dynamics between transaction characteristics, anticipated transaction costs and contract types in complicated relationships such as BPO relationships.
Continuance intention in running apps: the moderating effect of relationship norms
Authors: Cheng Li Keng , Huang Hsien-Long , Lai Ching-Chi 
Published: May 2021

PurposeThe number of people using running apps has increased. Accordingly, a growing number of sports brands are launching running apps in hopes of improving their connection with consumers and thereby enhancing consumers' brand preference and purchase intention. This study adopted an integrated perspective to explore the effects of perceived usefulness, perceived ease of use and self-expression on consumers' continued use of running apps.Design/methodology/approachConvenience sampling was conducted among consumers in Taiwan (n = 251). Structural equation modeling using AMOS 21 was performed to analyze the data.FindingsThe study results revealed that (1) users' perceived usefulness, perceived ease of use and self-expression significantly positively affected continuance intention, and (2) continuance intention was significantly positively correlated with word-of-mouth (WOM) and brand intimacy. Furthermore, the study confirmed the moderating effect of consumers' relationship norms on the correlation between continuance intention and WOM and brand intimacy.Originality/valueAmid the increasing emphasis on self-expression, almost all running apps endeavor to enable users to share their achievements, such as accumulated mileage and routes. However, research has rarely focused on whether these features influence consumers' continued use of running apps and whether these influences in turn affect consumers’ attitudes toward a brand. Therefore, this study explored the effect of self-expression on the continued use of running apps.
Elderly and middle-aged intention to use m-health services: an empirical evidence from a developing country
Authors: Moudud-Ul-Huq Syed , Sultana Swarna Rebeka , Sultana Mahmuda 
Published: May 2021

Purpose
m-health services for different age groups are becoming an emerging field in the health-care industry, especially in low-resource environments such as developing countries such as Bangladesh. Hence, this study’s primary aim is to identify the factors that influence the middle-aged and elderly’s intention to use m-health services.

Design/methodology/approach
This study applied the extended version of the unified theory of acceptance and use of technology to explore middle-aged and elderly’s intention to use m-health services. There were 235 respondents, of which 123 (52.34%) were in the middle-aged group, whereas 112 (47.66%) were in the older group. Both groups were found to have more male participants than female participants. The partial least square (PLS) method was used to analyze data.

Findings
The study found that performance expectancy, effort expectancy, facilitating condition, technological anxiety and resistance to change (p < 0.05) had a significant influence on middle-aged intention to use m-health services. Social influence and perceived physical condition (p > 0.05) had no significant effect on middle-aged intention to use m-health services. On the other hand, performance expectancy, effort expectancy, facilitating condition and resistance to change (p <* 0.05) significantly influenced the elderly’s intention to use m-health services. However, the social impact of perceived physical condition and technological anxiety (p > 0.05) had no significant effect on the elderly’s intention to use m-health services.

Originality/value
A good number of studies are available in the current literature, examining the factors adoption of m-health services in both developed and developing economy context. However, very few studies examine the factors that influence behavioral intention to use m-health services concerning the two different age groups, such as middle-aged and elderly. Moreover, to the best of the authors’ knowledge, there is a shortage of literature on this topic built on the comparative analysis between the two age groups.
The role of transformative healthcare technology on quality of life during the COVID-19 pandemic
Authors: Salam Mohammad Asif , Bajaba Saleh 
Published: May 2021

Purpose
The purpose of this study is to investigate the role of the COVID-19 health-care system quality (HSQ) and its impact on the individual (satisfaction) and social (quality of life [QOL]) outcomes in the context of a transformative health-care delivery system using service-dominant logic (SDL).

Design/methodology/approach
A sample consisting of 1,008 individuals who have experienced the COVID-19 health-care system was drawn from four different regions of Saudi Arabia using the simple random sampling technique. The survey was conducted using an online survey and 1,008 respondents answered, based on their experience and knowledge of the COVID-19 health-care system. Partial least squares structural equation modeling was applied to test the proposed research model.

Findings
The study findings suggest that service system satisfaction (SAT) significantly mediates the role of the HSQ in delivering and enhancing the QOL. HSQ also has a significant role to play on the SAT as well as the QOL. These findings contribute to the body of knowledge on SDL in the context of HSQ in understanding the significant role of technologies can play in enhancing service satisfaction and better QOL during a crisis such as COVID-19. This study also improves the understanding of the importance of customer-centricity, real-time visibility through tracking and tracing of service flow, agile decision-making, fewer but better-defined service objectives, and finally shaping mindsets and behaviors of all the relevant parties involved in the HSQ service delivery process.

Research limitations/implications
One of the major limitations of this study is that, although COVID-19 is an ongoing global pandemic, cross-sectional data were collected in only one country. The findings may not be generalizable across subsequent waves of the pandemic. The best practices of HSQ could be studied around the globe and the results used to support continuous improvement.

Originality/value
This study advances the understanding of the SDL in the context of a transformative health-care system for a transitional economy by focusing on individual and social well-being during an unexpected crisis such as the COVID-19 pandemic. This study also contributes toward the understanding of the roles of enabling technologies to improve the service delivery system which results in an improved SAT, as well as better QOL for the society at large. Based on SDL this research validates the HSQ model, relevant measures and its overall impact on SAT and QOL in the context of a transformative health-care service system in Saudi Arabia.
Does e-government control corruption? Evidence from South Asian countries
Authors: Ali Muhammad , Raza Syed Ali , Puah Chin Hong , Arsalan Tazeen 
Published: May 2021

Purpose
This study aims to examine the relationship between e-government and corruption in selected South Asian countries (Pakistan, India, Bangladesh and Sri Lanka).

Design/methodology/approach
The sample data were gathered from reliable secondary sources over a sample period of 2003–2018. Additionally, this study incorporated other potential determinants or corruption, such as government effectiveness, press freedom, education and economy. To assess sample data, this study used panel data econometric procedures.

Findings
Results indicated that e-government had a positive and significant impact on corruption. Similarly, government effectiveness and education had a positive and significant influence on corruption. However, press freedom and the economy showed a negative and insignificant impact on corruption. This study further found the robustness of the results through sensitivity analysis. Overall, it was concluded that e-government plays a significant role to reduce corruption.

Originality/value
The governments should implement the e-governance system and provide a transparent and accountable environment to eliminate corruption.
Pandemic and the performing arts in New Zealand
Authors: Ramachandra Suresh 
Published: May 2021

Purpose
This paper aims to document the narratives that emerged in favour of and against the austerity measures proposed by the Auckland Council, with specific reference to performing arts organisations (PAOs) in the aftermath of the pandemic 2020.

Design/methodology/approach
Written submissions from stakeholders received in response to austerity measures were analysed to identify the arguments presented to support/oppose funding cuts to PAOs. These narratives were thematically grouped into accounting, political, artistic and social categories to deliberate on the tensions that exist between these when funding PAOs.

Findings
This study identifies the arguments presented by grass-root PAOs on the rationale of their existence from a Pacific perspective. The analysis suggests that accounting, hitherto considered as a “sword” can also be used as a “shield” if PAOs direct their research accordingly and offers future research directions.

Originality/value
Prior studies concerning funding difficulties of PAOs have relied on opinions obtained ex-post from selected stakeholders. There are no known studies, which factor the opinions of grass-root PAOs, captured “during” funding deliberations. This study bridges this gap in the New Zealand setting by providing an analysis of grass-root opinions from the Pacific perspective, conducted during a funding deliberation.
Postal or electronic voting? The analysis of the preferred voting methods in the context of failed electoral reform in Poland
Authors: Musiał-Karg Magdalena , Kapsa Izabela 
Published: May 2021

Purpose
This paper aims to discuss reasons for the failure of the 2020 postal-vote election reform in Poland and examine opinions of Poles on voting methods. The main goal is to answer the following research question: Which of the alternative voting methods – postal or electronic – would Poles prefer?

Design/methodology/approach
The approach is quantitative and based on the statistical analysis of voters’ attitudes toward alternative voting methods, in particular postal voting.

Findings
The main finding is that out of all voting methods available, most Poles favor electronic voting as a potential alternative to voting in person. On a general level, the conclusions from the Polish case highlight the need to establish special requirements and standards for democratic elections during emergency situations. The unsuccessful implementation of all-postal voting in Poland is an example of how changes to the law should not be made, especially when public health and democratic standards are at stake.

Practical implications
The paper presents practical implications and recommendations for state authorities and electoral administration while implementing electoral reforms, extending the list of available voting channels, and running elections – especially in extraordinary situations.

Originality/value
This paper adds to the knowledge on alternative voting channels, including their implementation during a pandemic. The Polish case is also relevant for other countries as regards safe and democratic elections during emergency situations. Policymakers are expected to benefit from the insight, as the results originate in public opinion polls and identify voting channels favored by citizens
Disturbance by invasive pathogenic fungus alters arthropod predator–prey food‐webs in ash plantations
Authors: Michalko Radek , Košulič Ondřej , Martinek Petr , Birkhofer Klaus 
Published: May 2021

Abstract

According to the disturbance‐succession theory, natural disturbances support biodiversity and are expected to increase the complexity of food‐webs in forest ecosystems by opening canopies and creating a heterogeneous environment. However, a limited number of studies have investigated the impact of disturbance by invasive pathogenic species and succession on arthropod predator–prey food‐webs in forest ecosystems.

Hymenoscyphus fraxineus is a pathogenic fungus of ash trees that is invasive in Europe and causes massive dieback, mainly of the common ash Fraxinus excelsior across its native range. Here we investigated how this pathogenic fungus affects food‐webs of web‐building spiders and their prey in understorey vegetation of ash plantations.

In 23 young and middle‐aged ash plantations that were distributed along a gradient of infestation by H. fraxineus (29%–86% infestation), we measured the vegetation structure (canopy openness, shrub coverage, herb/grass coverage), the trait composition of local spider communities (web type, body size), the prey availability and the prey intercepted by spider webs. We then evaluated the multivariate prey composition (prey type, body size) and network properties.

Hymenoscyphus fraxineus opened the ash tree canopy, which resulted in denser shrub coverage. The dense shrub vegetation changed the composition of web types in local spider communities and increasing fungus infestation resulted in reduced mean body size of spiders. Infestation by H. fraxineus reduced the availability of predaceous Coleoptera and increased the availability of herbivorous Coleoptera as potential prey. The mean body size of captured prey and the per capita capture rates of most prey groups decreased with increasing fungus infestation. Hymenoscyphus fraxineus infestation indirectly reduced the complexity in bipartite networks and the trophic functional complementarity in local web‐building spider communities. The plantation age affected the vegetation structure but did not affect the studied food‐webs.

Forest disturbance by the invasive pathogen affected four trophic levels (plant–herbivore–coleopteran intermediate predator–top predator web‐building spiders) and, contrary to the disturbance‐succession theory, disturbance by the fungus simplified the web‐building spider‐prey food‐webs. The results support the view that H. fraxineus represents a threat to the biodiversity and ecosystem functioning in the simplified ecosystems of ash plantations.
Reciprocal transplant gardens as gold standard to detect local adaptation in grassland species: New opportunities moving into the 21st century
Authors: Johnson Loretta C. , Galliart Matthew B. , Alsdurf Jacob D. , Maricle Brian R. , Baer Sara G. , Bello Nora M. , Gibson David J. , Smith Adam B. 
Published: May 2021

AbstractLocal adaptation is a fundamental phenomenon in evolutionary biology, with relevance to formation of ecotypes, and ultimately new species, and application to restoration and species’ response to climate change. Reciprocal transplant gardens, a common garden in which ecotypes are planted among home and away habitats, are the gold standard to detect local adaptation in populations.This review focuses on reciprocal transplant gardens to detect local adaptation, especially in grassland species beginning with early seminal studies of grass ecotypes. Fast forward more than half a century, reciprocal gardens have moved into the genomic era, in which the genetic underpinnings of ecotypic variation can now be uncovered. Opportunities to combine genomic and reciprocal garden approaches offer great potential to shed light on genetic and environmental control of phenotypic variation. Our decadal study of adaptation in a dominant grass across the precipitation gradient of the US Great Plains combined genomic approaches and realistic community settings to shed light on controls over phenotype.Common gardens are not without limitations and challenges. A survey of recent studies indicated the modal study uses a tree species, three source sites and one growing site, focuses on one species growing in a monoculture, lasts 3 years, and does not use other experimental manipulations and rarely employs population genetic tools. Reciprocal transplant gardens are even more uncommon, accounting for only 39% of the studies in the literature survey with the rest occurring at a single common site. Reciprocal transplant gardens offer powerful windows into local adaptation when (a) placed across wide environmental gradients to encompass the species’ range; (b) conducted across timespans adequate for detecting responses; (c) employing selection studies among competing ecotypes in community settings and (d) combined with measurements of form and function which ultimately determine success in home and away environments.Synthesis. Reciprocal transplant gardens have been one of the foundations in evolutionary biology for the study of adaptation for the last century, and even longer in Europe. Moving forward, reciprocal gardens of foundational non‐model species, combined with genomic analyses and incorporation of biotic factors, have the potential to further revolutionize evolutionary biology. These field experiments will help to predict and model response to climate change and inform restoration practices.