bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal autoimmune disease is not associated with cancer in the offspring
Authors: Seppälä Laura K. , Madanat‐Harjuoja Laura‐Maria , Troisi Rebecca , Sampson Joshua N. , Leinonen Maarit K. , Vettenranta Kim 
Published: February 2021

AbstractAimAutoimmune disease and its medication are associated with increased cancer risk in adults, but it is unknown whether maternal autoimmune disease and/or medication use in pregnancy are associated with increased cancer risk in offspring.MethodsIn this case‐control study, we identified all patients under 20 years of age with their first cancer diagnosis in 1996–2014 from the Finnish Cancer Registry (n = 2029) and 1:5 population‐based controls (n = 10,103) from the Medical Birth Register. We obtained information on maternal autoimmune disease and its medication from the relevant Finnish registries and used conditional logistic regression to analyse the risk of offspring cancer after maternal autoimmune disease exposure.ResultsThe odds ratio (OR) for cancer in offspring following maternal autoimmune exposure was 0.76 (95% confidence interval [CI] 0.47–1.23). Individual ORs for inflammatory bowel and connective tissue diseases were 1.08 (95% CI 0.56–2.01) and 0.50 (95% CI 0.23–1.08), respectively. The OR for maternal autoimmune medication was 0.95 (95% CI 0.80–1.14) overall and similar by drug subtype. There was an increased risk with medication in late pregnancy but the ORs were unstable owing to small numbers.ConclusionOur study does not support an increased cancer risk among offspring of women with autoimmune disease or its medication during pregnancy.
Validation of a phenol‐sulfuric acid method in a microplate format for the quantification of soluble sugars in ruminant feeds
Authors: Kondo Makoto , Mulianda Randi , Matamura Masaya , Shibata Toshiyuki , Mishima Takashi , Jayanegara Anuraga , Isono Naoto 
Published: February 2021

AbstractSoluble sugars in feeds are important for ruminant production; however, performing numerous sugar analyses within a short period is a laborious task. Here, we developed a phenol‐sulfuric acid (PSA) assay in a microplate format to quantify soluble sugars in ruminant feeds. This method is easy and quick and requires only a small quantity of harmful reagents. We found that assay measurements were not affected by the representative organic acids and sugar alcohol contained in feeds. The treatment of activated charcoal with ethanol extract prior to the PSA assay was effective in removing interfering compounds for a more accurate determination of soluble sugars in certain feeds. Furthermore, the inter‐day and intra‐day repeatability of the present method was acceptable. Hence, we conclude that the method developed in this study is suitable for routine analysis of soluble sugars content in ruminant feeds.
Estimation of the marbling development pattern in Japanese Black cattle by using serial ultrasound measurement data
Authors: Tokunaga Tadaaki , Jomane Fortune N. , Mandai Shintarou , Ishida Takafumi , Hirooka Hiroyuki 
Published: February 2021

AbstractThe objective of this study was to develop mathematical equations for describing the change in marbling in Japanese Black steers using longitudinal measurements. Serial ultrasound measurements were taken at 14, 16, 20, and 26 months of age and analyzed using an image analysis software. The longitudinal marbling measurements from the ultrasound images and carcasses were fitted into a nonlinear logistic curve. Data used for the analysis consisted of 749 steers that converged in nonlinear curve fitting and showed reasonable estimated parameters of the logistic curves. The average predicted mature beef marbling score (BMS) and maturation rate were 6.26 and 0.353, respectively, and the average maturity levels at 24 months of age were 83.9%. The heritability estimates for the predicted maturity traits were moderate, indicating that these traits may have potential for genetic improvement. There was a negative relationship between the expected progeny differences between carcass BMS and maturity traits, suggesting that genetic improvement by carcass BMS may lead to the selection of bulls with late maturity for marbling. The results indicate that ultrasound and model building for marbling can be useful tools to correctly select candidate bulls with high marbling in the early fattening period.
Thirty Years of The Australian Accounting Review: A Bibliometric Analysis
Authors: Pattnaik Debidutta , Kumar Satish , Burton Bruce 
Published: February 2021

AbstractThis study presents a retrospective review of the Australian Accounting Review (AAR) across its first 30 years of publication, 1991 to 2020. AAR’s academic contributions have grown by 17.01% year‐on‐year over this period, while its level of academic influence has risen by 20.21%. Authorship numbers have grown by 16.10% annually, from 11 authors in the year of inception to 969 individuals in 2020. Emerging initially as an important regional resource, the AAR has evolved to become an internationally renowned academic outlet with contributions sourced from 44 different countries. Emergent themes in the journal include integrated reporting, corporate social responsibility, investor protection and comprehensive income.
Role of A‐ and B‐type lamins in nuclear structure–function relationships
Authors: Patil Shalaka , Sengupta Kundan 
Published: February 2021

AbstractNuclear lamins are type V intermediate filament proteins that form a filamentous meshwork beneath the inner nuclear membrane. Additionally, a sub‐population of A‐ and B‐type lamins localizes in the nuclear interior. The nuclear lamina protects the nucleus from mechanical stress and mediates nucleo‐cytoskeletal coupling. Lamins form a scaffold that partially tethers chromatin at the nuclear envelope. The nuclear lamina also stabilises protein–protein interactions involved in gene regulation and DNA repair. The lamin‐based protein sub‐complexes are implicated in both nuclear and cytoskeletal organisation, the mechanical stability of the nucleus, genome organisation, transcriptional regulation, genome stability and cellular differentiation. Here, we review recent research on nuclear lamins and unique roles of A‐ and B‐type lamins in modulating various nuclear processes and their impact on cell function.
Design, synthesis, and biological evaluation of novel 4,4‐difluoro‐1‐methyl‐N, 6‐diphenyl‐5, 6‐dihydro‐4H‐pyrimido [4, 5‐b] [1, 2, 4] triazolo [4, 3‐d] [1, 4] diazepin‐8‐amine derivatives as potential BRD4 inhibitors
Authors: Li Jiuhui , Zhang Wenjie , Qiu Qianqian , Zhou Daoguang , Feng Ziying , Tong Zhenzhen , Wei Jiaxin , Huang Wenlong , Li Jieming , Qian Hai , Shi Wei 
Published: February 2021

AbstractBromodomain‐containing protein 4 (BRD4) plays an extremely important physiological role in cancer, and the BRD4 inhibitors can effectively inhibit the proliferation of tumor cells. By taking BI‐2536 (PLK1 and BRD4 inhibitor) as the lead compound, sixteen novel BRD4 inhibitors with the 4,4‐difluoro‐1‐methyl‐N,6‐diphenyl‐5,6‐dihydro‐4H‐pyrimido[4,5‐b] [1,2,4] triazolo[4,3‐d] [1,4] diazepine‐8‐amine structure were designed and synthetized. Among the target compounds, compound 15h exhibited outstanding inhibition for BRD4‐BD1 (IC50 value of 0.42 μM) in the BRD4‐BD1 inhibitory activity assay. Additionally, cell growth inhibition assay demonstrated that compound 15h potently suppressed the proliferation of MV4‐11 cells (IC50 value of 0.51 μM). Besides, compound 15h induced apoptosis and G0/G1 cycle arrest in MV4‐11 leukemia cells effectively, and downregulated the expression of c‐Myc in a dose‐dependent manner. In summary, the optimal compound 15h is expected to become the clinical therapeutic drug for further research.
Toll‐like receptor 4 antagonist FP7 alleviates lipopolysaccharide‐induced septic shock via NF‐kB signaling pathway
Authors: Li Chao , Wang Junhui , Zhao Mailiang , Zhang Sheng , Zhang Yanwei 
Published: February 2021

AbstractSeptic shock is the most severe complication of sepsis occurs when body has an overwhelming response to infection, making it the most prevalent cause of deaths in surgical intensive‐care units. Therefore, it is urgent to understand its pathogenesis and develop new therapeutic candidate drugs for septic shock. Here, we explored the effect of FP7, an antagonist of Toll‐like receptor 4 (TLR4), in the septic shock. First, we injected mice with FP7 and found that FP7 had no effect on immune cells. Then, bone marrow‐derived macrophages (BMDMs) isolated from mice were pretreated with FP7 followed by lipopolysaccharide (LPS) stimulation, and FP7 specifically suppressed LPS‐induced inflammatory responses in BMDMs via Nuclear factor kappa‐light‐chain enhancer of activated B cells (NF‐κB) signaling pathway, with no effect on other TLRs‐mediated inflammations. Finally, we injected mice with LPS and D‐galactosamine to induce septic shock, followed by the treatment of FP7, and FP7 significantly increased survival rate, improved lung necrosis, and inhibited the secretions of proinflammatory cytokines in the mice with septic shock. Therefore, our study suggested that FP7 had a protective role in septic shock and it might serve as a promising therapeutic candidate drug to treat septic shock.
Thriving alongside cystic fibrosis: Developing a grounded theory of empowerment in children and young people with cystic fibrosis during key life transitions
Authors: Fairweather Naomi H. , Jones Fergal W. , Harris Sally A. , Deiros Collado Martha , Shayle Amy 
Published: February 2021

AbstractBackgroundAlthough the importance of patient empowerment is increasingly recognized, little is known about empowerment in children and young people (CYP) with long‐term conditions. Empowerment may be particularly important in CYP with cystic fibrosis (CF) due to high treatment burden and limited opportunities for peer support.MethodsA Grounded Theory method was employed to develop a preliminary theory of empowerment in CYP with CF. Seven CYP with CF, five parents and four professionals were interviewed.Results and conclusionsThe emerging model suggests that ‘thriving alongside CF’ may be supported by interactions between ‘having a team’ and ‘taking charge and having a voice’, leading to ‘being able to just be a child’, that ‘concealing self’ may get in the way of ‘thriving alongside CF’ and that these processes occur within wider medical and developmental contexts. Study limitations, clinical and research implications are discussed.
Perspectives of nurturance within the parent–child relationship in resource‐constrained families
Authors: Goldschmidt Tessa , Petersen Lisa , Booley Shakierah , Roman Nicolette V. 
Published: February 2021

AbstractBackgroundNurturing parents raise children in an engaged, flexible, emotionally expressive and supportive manner, which is associated with positive outcomes for children. While parenting research within the South African context is increasing, there is a lack of focus on nurturance within the parent–child relationship. Thus, this study sought to explore how parents nurture their children in resource‐constrained environments in South Africa.MethodA qualitative approach with an exploratory research design was used. Participants were purposively recruited via non‐governmental institutions and key informants in the communities. A sample of 77 semi‐structured interviews was conducted with participants from two rural areas, Calvinia and Lamberts Bay, in South Africa.ResultsA thematic analysis of the data revealed two themes. The first theme is nurturance approaches, which encapsulate how parents nurture their children physically and emotionally. The second theme focuses on factors contributing to nurturance within the parent–child relationship with regard to parenting practices and external factors.ConclusionAlthough parents are nurturing children physically and emotionally, parenting capacity needs to be improved in the South African context.
Two‐piece zirconia implants supporting all‐ceramic crowns: Six‐year results of a prospective cohort study
Authors: Cionca Norbert , Hashim Dena , Mombelli Andrea 
Published: February 2021

AbstractObjectivesThe aim of this prospective clinical trial was to present the 6‐year outcomes of a two‐piece yttria‐stabilized tetragonal zirconia polycrystals (Y‐TZP) implant system in partially edentulous patients.Material and methodsForty‐nine two‐piece zirconia implants were placed in 32 patients systemically healthy. Zirconia abutments were connected with adhesive resin cement. Single‐unit full‐ceramic crowns were cemented. The cases have been followed for an average of 82.2 ± 5.86 months after loading (range 74.93–92.26 months).Results24 participants with 39 implants were available for examination 6 years after loading. The cumulative implant survival rate was 83%. On an implant level, the cumulative mechanical complication rate was 17.5%, the cumulative technical complication rate was 13%, and the biological complication rate was 8%. After 6 years, subjects reported good satisfaction with the treatment: 3.7 ± 4.4 on a visual analog scale (VAS) from 0 to 100 mm.ConclusionsWithin the limitations of this prospective case series study, two‐piece zirconia implants could offer an alternative for treatment of single edentulous spaces in the posterior region. The major complication on the long term of this pioneering system was the abutment fracture; however, due to the versatility of a two‐piece implant system, replacement of the broken parts was possible.
Interactive online informational and peer support application for patients with low anterior resection syndrome: patient survey and protocol for a multicentre randomized controlled trial
Authors: Moon Jeongyoon , Monton Olivia , Smith Allister , Garfinkle Richard , Zhao Kaiqiong , Zelkowitz Phyllis , Loiselle Carmen G. , Fiore Julio F. , Sender Liberman A. , Morin Nancy , Faria Julio , Ghitulescu Gabriela , Vasilevsky Carol‐Ann , Bhatnagar Sahir R. , Boutros Marylise 
Published: February 2021

AbstractAimLow anterior resection syndrome (LARS) refers to a constellation of bowel symptoms that affect the majority of patients following restorative proctectomy. LARS is associated with poorer quality of life (QoL), and can lead to distress, anxiety and isolation. Peer support could be an important resource for people living with LARS, helping them normalize and validate their experience. The aim of this work is to describe the development of an interactive online informational and peer support app for LARS and the protocol for a randomized controlled trial.MethodA multicentre, randomized, assessor‐blind, parallel‐groups pragmatic trial will involve patients from five large colorectal surgery practices across Canada. The trial will evaluate the impact of an interactive online informational and peer support app for LARS, consisting of LARS informational modules and a closed forum for peers and trained peer support mentors, on patient‐reported outcomes of people living with LARS. The primary outcome will be global QoL at 6 months following app exposure. The treatment effect on global QoL will be modelled using generalized estimating equations. Secondary outcomes will include patient activation and bowel function as measured by LARS scores.ResultsIn order to better understand patients' interest and preferences for an online peer support intervention for LARS, we conducted a single institution cross‐sectional survey study of rectal cancer survivors. In total, 35/69 (51%) participants reported interest in online peer support for LARS. Age <65 years (OR 9.1; 95% CI 2.3‐50) and minor/major LARS (OR 20; 95% CI 4.2‐100) were significant predictors of interest in LARS online peer support.ConclusionThere is significant interest in the use of online peer support for LARS among younger patients and those with significant bowel dysfunction. Based on results of the needs assessment study, the app content and features were modified reflect patients’ needs and preferences. We are now in an optimal position to rigorously test the potential effects of this initiative on patient‐centered outcomes using a randomized controlled trial.
Exploring the intersections of governance, constituencies, and risk in genetic interventions
Authors: Burgiel Stanley W. , Baumgartner Bridget , Brister Evelyn , Fisher Joshua , Gordon Doria R. , Novak Ben , Palmer Megan J. , Seddon Philip J. , Weber Michele 
Published: February 2021

AbstractIn June 2020, Revive & Restore hosted the Intended Consequences Workshop to explore how the field of conservation can realize the benefits of genetic interventions and address concerns about unintended consequences of these actions. A group of 57 participants from eight countries representing government, academia, and conservation practice discussed how implementation of genetic interventions designed to achieve conservation objectives can be optimized to both address concerns about risk and achieve the intended consequences. Genetic interventions are efforts designed to manipulate the genetic composition of a conservation target at a species or population level. The planning and implementation of genetic interventions in conservation raises questions about how key constituencies are involved in the process and how risks and benefits are characterized and evaluated. Governance frameworks are critical to structuring dialogue and decision‐making among interested parties around the development of these conservation efforts in a manner that addresses risks, benefits, and equity considerations. In this article, we explore related issues of policy and governance, key constituencies, and risk as raised during discussions at a 2020 workshop on “Intended Consequences” of conservation interventions. We examine how different constituencies characterize risks of genetic interventions within particular sociocultural contexts. We then revisit the characterization and framing of risks to suggest ways that the perspectives of different constituencies can be visualized in a manner to inform resulting policy decisions.
Investments in worker health and production: Evidence from Vietnam
Authors: Filippini Massimo , Srinivasan Suchita 
Published: February 2021

AbstractIn manufacturing industries, occupational health and safety measures ensure better working conditions for employees, which may influence their productivity. We study the impact of investments undertaken by small and medium enterprises in Vietnam in mitigating indoor pollution (including air quality improvements, heat and noise protection as well as lighting) on firm‐level gross output and value added. We find that the amount invested by the firm in health has a significant positive effect on both outcomes. Given historically poor working conditions in Vietnam, policy implications relate to incentivizing and enabling firms to undertake such investments, on both moral and economic grounds.
Effects of inter‐specific crossbreeding between the invasive pine wood nematode, Bursaphelenchus xylophilus and native B. mucronatus on morphology and reproduction of the hybrid offspring
Authors: Tomalak Marek , Filipiak Anna 
Published: February 2021

AbstractThe process of inter‐specific hybridization between the invasive, highly pathogenic pinewood nematode, Bursaphelenchus xylophilus and the Eurasian‐native, relatively harmless B. mucronatus has been examined with the aid of the B. xylophilus Roller (Bxy‐rol(tom3) mutation (Tomalak & Filipiak, 2019) as a morphological marker, in the breeding protocol. Validity of the morphologically based selection of the inter‐specific hybrids has been confirmed by examination of individual nematodes with the multiplex PCR technique with specific primers (Filipiak et al., 2017). The research showed that hybridization between both species was possible in F1 and to some extent in subsequent offspring generations. In the general body plan, the hybrids resembled the wild‐type parental species but differed in various morphological/anatomical details. The changes ranged from seemingly indistinct to heavily distorted or occasional missing of particular structures. The most affected were spicules, female tails, the development of gonads and the position of the excretory pore. The hybridization led to various distortions of mating, gametogenesis, embryogenesis and juvenile viability, and development in F1, F2 and subsequent generation offspring, which severely affected the nematode reproductive potential. Potential consequences of the spontaneous inter‐specific hybridization between both species are discussed.
Long‐term cardiac, vascular, hypertension, and effusion safety of bosutinib in patients with Philadelphia chromosome–positive leukemia resistant or intolerant to prior therapy
Authors: Cortes Jorge E. , Kantarjian Hagop M. , Mauro Michael J. , An Fiona , Nick Sonja , Leip Eric , Gambacorti‐Passerini Carlo , Brümmendorf Tim H. 
Published: February 2021

AbstractIntroductionLong‐term follow‐up (≥4 years) demonstrated a low incidence of cardiac and vascular treatment‐emergent adverse events (TEAEs) with bosutinib treatment. We evaluated cardiac, vascular, hypertension, and effusion TEAEs after ≥ 7 years of follow‐up in patients with Philadelphia chromosome–positive (Ph+) leukemia.MethodsThis retrospective analysis of a phase I/II study and its ongoing extension study included data from patients with chronic phase chronic myeloid leukemia (CML) treated with bosutinib after resistance/intolerance to imatinib (CP2L) or to imatinib plus dasatinib and/or nilotinib (CP3L), and those with accelerated/blast phase CML or acute lymphoblastic leukemia after treatment with, at a minimum, imatinib (ADV).ResultsIn all, 570 patients were treated with bosutinib; median treatment duration was 11.1 months (range: 0.03‐133.1). The incidence of cardiac, vascular, hypertension, and effusion‐related TEAEs was 10.9%, 8.8%, 9.1%, and 13.3%, respectively. Few patients had maximum grade 3‐4 TEAEs (cardiac, 3.9%; vascular, 4.0%; hypertension, 3.0%; effusion, 4.6%). Grade 5 TEAEs occurred in the cardiac (0.7%) and vascular (1.8%) clusters only. In years 5‐7, fewer than 5% of patients each year had newly occurring cardiac, vascular, hypertension, or effusion TEAEs. The exposure‐adjusted TEAE rates (patients with TEAEs/total patient‐year) pooled across CP2L, CP3L, and ADV cohorts were as follows: cardiac, 0.044; vascular, 0.035; hypertension, 0.038; and effusion, 0.056, of which, correspondingly, 0.9%, 1.2%, 0%, and 2.1% required treatment discontinuation.ConclusionsThe incidence of cardiac, hypertension, vascular, and effusion events was low in patients with Ph+ CML resistant or intolerant to prior therapy who were treated with bosutinib.