bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Metastases of Endometrial Carcinoma Treated by Surgery: Report on 13 Patients and Review of The Medical Literature
Authors: Wang Jingyuan , Dai Yibo , Ji Tao , Guo Wei , Wang Zhiqi , Wang Jianliu 
Published: January 2021

Abstract

Objective: The aim of this study was to describe the clinicopathological features of EC patients with bone metastases treated with surgery and to systematically review the literature. Methods: We performed a retrospective study to include patients with bone metastases of EC at Peking University People’s Hospital during 2000 to 2019. Clinicopathological features and survival outcomes were collected.Results: Among the 1662 patients with EC, 14 (0.84%) were identified with bone metastases, and all were treated surgically. 13 cases were analyzed. Four had bone metastases when diagnosed; and the remaining 9 cases had bone metastases when first relapsed with the median time to recurrence of 13 months (range, 5-144). The median age of the 13 patients was 58 years old (range, 45-76). Twelve were endometrioid carcinoma. The majority sites of bone metastases were pelvis, followed by the spine. The median overall survival (OS) was 57 months. We further combined the 13 patients with another 24 cases identified from literature research. There was no significant difference in clinicopathological characteristics between the patients with bone metastases when diagnosed and when first relapsed. The median OS was numerically longer for patients with bone metastases when diagnosed than when first relapsed (57 vs. 36 months, P=0.084). The median OS was significantly longer in patients with endometrioid carcinoma than in those with type II carcinoma (57 vs. 4 months, P=0.003). Conclusions: Patients with bone metastases of EC might benefit from comprehensive treatment based on surgery, as symptoms can be palliated and survival can be extended probably.
Scalable Analysis of COVID-19 Spatiotemporal Patterns Based on Data Mining Tools: Using 3D Bins to Predict Short-time Focus Locations
Authors: Cos Olga de , Castillo Valentín , Cantarero David 
Published: January 2021

Abstract
Background: An interesting research line is related to COVID-19 behavior from a territorial and temporal perspective. Hence, the use of 3D space-time bins is a useful tool to contrast limitations of visual assessment and reveal the detailed areas most at risk for the pandemic or even more the emergency hotspots can be useful to not only study but also predict spatial pattern of the COVID-19 at an intra-urban scale.Methods: We developed the SITAR Fast Action Territorial Information System using ESRI Technologies Ecosystem. More specifically, we used ArcGIS Pro (desktop) and ArcGIS Online (cloud). Therefore, our general research methodology is based on Geographic Information Technologies from a multiscalar perspective and based on detailed entities (geocoded COVID-19 cases for the region of Cantabria, Spain). The main research method is related to data mining tools using 3D bins and analysing emerging hotspots.Results: The spatial autocorrelation analysis of the COVID-19 reveals that the distribution of the cases is not random. Otherwise, the Moran´s Index confirms that the spatial pattern of COVID-19 cases is statistically significative, and it presents a clustered distribution. And in the cases of elderly homes, COVID-19 outbreaks and spatial focus are linked while in the rest of the cases there is not this spatial association. The analysis of 3D bins and emerging hotspots is revealing from the point of view of geoprevention in that it significantly limits the territory on which it would be important to focus the analysis. In fact, of the 1,414 starting cubes, focusing on the 602 remaining cubes (with statistical significance), all correspond to a hotspot pattern.Conclusions: Our results evidence the existence of significant space-temporal trends that it can serve as support of emerging hotspots of COVID-19 that it can be used as a prelude to what will happen in the next future. To our knowledge, this is the first study for Spain that demonstrates the interest of the 3D space-time cubes method to engage the prevention measures proposed by policy makers with a scalar perspective. 3D bins can therefore be used as a proxy to assess the spatiotemporal patterns in public health studies.
577-nm High-Power Optically Pumped Semiconductor Laser is Safe and Effective in The Treatment of Inflammatory Acne: A Prospective, Single-Center, Split-Face Comparative Study
Authors: EEM Mohamed , Tawfik KM , IB Elsayed , Boelke Edwin , PA Gerber 
Published: January 2021

Abstract
Objective: This study aimed to appraise the efficacy of a 577 nm high-power optically pumped semiconductor laser (HOPSL) for the treatment of inflammatory acne.Methods: The study included 50 patients with acne vulgaris (inflammatory type), 14 men, and 36 females; patient ages ranged from 16 to 35 years. The left side of the face was treated with a single pass of a 577 nm high-power optically pumped semiconductor laser every 2 weeks for 3 sessions. Patients were examined prior to the first session and 4 weeks after the last session (Investigator's Global Assessment of acne severity, IGA; single lesion count).Results: At baseline, no statistically significant difference in the severity of inflammatory acne lesions between both sides was observed. One month after the final session, a significant improvement (IGA reduction of >50 percent) of the over-all severity of the acne was observed in 49 patients (98 percent) on laser-treated side versus 41 (82 percent) the control side of the face (P < .05). Accordingly, we found a significant reduction in the mean percentage of inflammatory papules, pustules, and nodules (79.33 vs 56.92, 78.04 vs 43.33, 64.85 vs 21.93 percent, respectively) (P<0.05). Side effects in the form of erythema and irritation during sessions were transient and tolerated by the patients.Conclusion: The 577 nm high-power optically pumped semiconductor laser is effective and safe for the treatment of inflammatory lesions (papules, pustules, and nodules) in acne patients.Running title: 577 nm high-power optically pumped semiconductor laser (HOPSL) for the treatment of inflammatory acne
A Randomized Study on The Prophylactic Use of Acetaminophen to Prevent Fever After The Removal of Drainage Tubes in Lumbar Surgery
Authors: Ye Kaifeng , Li Yan , Xing Yong , Liu Kaixi , Zhu Tengjiao , He Baichuan , Zhou Fang , Tian Yun , Zhang Yanping 
Published: January 2021

Abstract
Study design: a prospectively random clinical trialObjective: To explore the efficacy of prophylactic use of Acetaminophen in preventing fever after the removal of tube drainage in lumbar surgery.Summary and background data: Many inpatients encountered a fever in the first 24 hours when the drainage tube was removed. When fevers appeared, it was costly to exclude the possibility of deep infection and always failed to identify the etiology. Just like the postoperative fever, we suggested that the fever was caused by the normal inflammatory response, and tried to figure out whether the prophylactic use of Acetaminophen could lower the possibility of fever or not.Methods: 183 consecutive patients undergoing lumbar spine surgery were prospectively randomized into 2 groups. 91 patients were allocated into the study group, they would receive a pill of Acetaminophen (Tylenol, 650mg) before the removal of lumbar tube drainage, and another one at 8p.m. The rest 92 patients were divided into the control group, they were treated in routine treatment without Acetaminophen. In the first 24 hours, a temperature higher than 37.7°C was defined as fever. The 2 groups were then compared for differences in age, gender, height, weight, body mass index (BMI), surgical segments, surgical time, blood loss, blood transfusion, American Society of Anesthesiologists (ASA) score, duration of the tube drainage, total volume of the drainage collection, variation of the levels of WBC, CRP, hospital stay since the removal of drainage to discharge and the rate of fever.Results: There were no differences in all the basic information of 2 groups, but the fever rate of the 2 groups had significant differences (P=0.006), the fever rate of the study group (14/91, 15.38%) was significant lower than the control group (30/92, 32.61%).Conclusion: Fever after the removal of tube drainage was caused by normal inflammation response, and a small dose of acetaminophen could significantly lower the possibility fever. Trail registration: This trail was registered in the ClinicalTrial.gov PRS on July 13, 2019, and the ID was NCT04042948.
Rainfall Driven and Wild-bird Mediated Avian Influenza Virus Outbreaks in Australian Poultry
Authors: Ferenczi Marta , Beckmann Christa , Klaassen Marcel 
Published: January 2021

Abstract
Globally, outbreaks of Avian Influenza Virus (AIV) in poultry continue to burden economies and endanger human, livestock and wildlife health. Wild waterbirds are often identified as possible sources for poultry infection. Therefore, it is important to understand the ecological and environmental factors that directly influence infection dynamics in wild birds, as these factors may thereby indirectly affect outbreaks in poultry. In Australia, where large parts of the country experience erratic rainfall patterns, intense rainfalls lead to wild waterfowl breeding events at temporary wetlands and increased proportions of immunologically naïve juvenile birds. It is hypothesized that after breeding, when the temporary wetlands dry, increasing densities of immunologically naïve waterbirds returning to permanent water bodies might strongly contribute to AIV prevalence in wild waterfowl in Australia. Since rainfall has been proven to be an important environmental driver in AIV dynamics in wild waterbirds in southeast Australia and wild waterbirds are identified globally to have a role in virus spillover into poultry, we hypothesise that rainfall events have an indirect effect on AIV outbreaks in poultry in southeast Australia. In this study we investigated this hypothesis by examining the timing of AIV outbreaks in poultry in and near the Murray-Darling basin in relation to temporal patterns in regional rainfall since 1970. Our findings support our hypothesis and suggest that the risk of AIV outbreaks in poultry increases after a period of high rainfall, with peak AIV risk two years after the onset of the high-rainfall period. This is presumably triggered by increased rates of waterbird breeding and consequent higher proportions of immunologically naïve juvenile waterbirds entering the population directly after major rainfall events, which subsequently aggregate near permanent water bodies when the landscape dries out.
Drivers of Soil Bacterial Diversity in Sandy Grasslands in China
Authors: Pan Chengchen , Feng Qi , Li Yulin , Yu Xiaoya , Ren Shilong 
Published: January 2021

Abstract
Bacteria constitute great abundances and groups on Earth and control many important processes in terrestrial ecosystems. However, our understanding of the interactions between soil bacteria and environmental factors remains limited, especially in sensitive and fragile ecosystems. In this study, geographic patterns of bacterial diversity across the four sandy grasslands along a 1600 km north-south transect in northern China were characterized by high-throughput 16S rRNA gene sequencing. Then, we analyzed the driving factors behind the patterns in bacterial diversity. The results showed that of the 21 phyla detected, the most abundant were Proteobacteria, Actinobacteria, Acidobacteria and Firmicutes (average relative abundance > 5%). Soil bacterial α diversity, calculated as the bacterial phylotype richness and Faith’s phylogenetic diversity, was highest in the Otingdag Sandy Land and lowest in the Mu Us Sandy Land. Soil EC was the most influential factor driving bacterial α diversity. The bacterial communities differed significantly among the four sandy grasslands, and the bacterial community structure was significantly affected by environmental factors and geographic distance. Of the environmental variables examined, climatic factors (MAT and MAP) and edaphic properties (pH and EC) explained the highest proportion of the variation in bacterial community structure. Biotic factors such as plant species richness and aboveground biomass exhibited weak but significant associations with bacterial α diversity. Our findings revealed the important role of climate and salinity factors in controlling bacterial diversity; understanding these roles is critical for predicting the impacts of climate change and promoting sustainable management strategies for ecosystem services in these sandy lands.
Hip Arthroscopy has Good Clinical Outcomes in the Treatment of Osteoid Osteoma of the Acetabulum
Authors: Gao Guanying , Wu Ruiqi , Liu Rongge , Ao Yingfang , Wang Jianquan , Xu Yan 
Published: January 2021

Abstract
Background: Osteoid osteoma (OO) of the acetabulum is a relatively rare disease. The clinical outcomes of hip arthroscopy for treatment of OO of the acetabulum is still uncertain.Methods: We evaluated consecutive patients who were diagnosed with OO of the acetabulum and underwent hip arthroscopy for treatment in our hospital between January 2013 and March 2020. All patients underwent preoperative physical examination. Preoperative supine anteroposterior hip radiographs, cross-table lateral radiographs, CT images, and MR images were obtained for all patients. Alpha angle and lateral center-edge angle were measured before surgery. Supine anteroposterior hip radiographs and CT images were obtained for all patients postoperatively. Preoperative patient-reported outcomes (PROs), including visual analog scale (VAS), the International Hip Outcome Tool-12 (iHOT-12) and modified Harris Hip Score (mHHS), and PROs at final follow-up were evaluated.Results: A total of 6 patients (mean age, 18.7 years; age range, 6-31 years; 5 males and 1 females) were included in this study. The average follow-up period after surgery was 28.3 months (range, 6–90 months). Before surgery, mean mHHS was 45.2±10.5 (range, 33-56), mean iHOT-12 was 33.3±14.5 (range, 13-49), and mean VAS was 8.2±1.0 (range, 7-9). At one month after surgery, mean mHHS was 78.7±1.9 (range, 77-81), iHOT-12 was 71.0±4.5 (range, 68-80), and mean VAS was 0. At the final post-operative follow-up, mean mHHS was 89.2±2.1 (range, 86-91), iHOT-12 was 93.5±5.0 (range, 88-98), and mean VAS was 0. All results, except VAS between one month after surgery and at final follow-up, demonstrated statistically significant improvement (P < 0.05). One patient underwent revision surgery.Conclusion: Hip arthroscopy has good clinical outcomes in the treatment of OO of the acetabulum.
Benefit Clarification of Longxuetongluo Capsule Towards Ischemic Stroke Rats by ischemic stroke rats by LC MS/MS Based Metabolomics
Authors: Jing Sun , Chen Xianyang , Fan Bei , Pan Bo , Liu Jiani , Chen Xiaonan , Zheng Jiao , Tu Pengfei , Han Jiarui , Song Yuelin , Jun Li 
Published: January 2021

Abstract
Background:Longxuetongluo Capsule (LTC) that was prepared from the phenolic compound cluster of Chinese dragon’s blood, has been clinically utilized for years towards ischemic stroke. However, its therapeutic mechanism s remain unclear. The present study aimed to evaluate the therapeutic effect and to explore the underlying mechanisms of LTC on ischemic stroke rats characterized by cerebral ischemia 6 re perfusion injury. Method:Ischemic stroke rats were simulated by middle cerebral artery occlusion ( and validated by the assays in terms of histological and behavioral assessments . The plasma metabolome comparisons amongst different groups were conducted by UHPLC Q Executive MS in combination with subsequent multivariate statistical analysis , aiming to finding the molecules in respond to the surgery or LTC treatment . Result:Intragastric administration of LTC significantly decreased not only the neurobehavioral abnormality scores but also the cerebral infarct area of MCAO rats. A total of 21 potential biomarkers related to ischemic stroke were observed, and 18 biomarkers (such as LysoPC, PE, SM, N1-Methyl-4-pyridone-3-carboxamide, PE (24:1/18:3 etc.) were selected after Youden index >0.7. The results showed that LTC was beneficial to ischemic stroke rats induced by ischemia reperfusion injury by Glycerophospholipid metabolism , Glycosylphosphatidylinositol (GPI) anchor biosynthesis , Nicotinate and nicotinamide metabolism and Sphingolipid metabolism Conclusion:The present study could provide evidence that metabolomics, as system systematicatic approach, revealed its capacity to evaluate tapproach, revealed its capacity to evaluate the holistic efficacy of TCM, he holistic efficacy of TCM, and investigate the molecular mechanism underlying the clinical treatment of LTC on and investigate the molecular mechanism underlying the clinical treatment of LTC on ischemic stroke. ischemic stroke.
An Outbreak of RSV Infections in the Neonatology Clinic of the University Obstetrics and Gynecology Hospital, Sofia, 2019 – a Case Series
Authors: Vakrilova Liliya , Nikolova Stanislava Hitrova – , Radulova Petya , Slancheva Boryana 
Published: January 2021

Abstract
Background: Respiratory syncytial virus (RSV) is the predominant cause of lower respiratory tract infections (LRTI) in infancy. Preterm infants with bronchopulmonary dysplasia (BPD) are at the highest risk of severe RSV-LRTI. We report retrospectively a nosocomial outbreak of RSV-infections in the Neonatology of the University O&G hospital, Sofia. Methods: Two groups of infants without contact between them were diagnosed with RSV-infection: 14 infants who were treated in the Department for healthy newborns, and 7 preterm infants, treated in the NICU. The detection of RSV was performed using Real-Time PCR in nasal/throat swabs.Results: Respiratory symptoms occurred 2-5 days after discharge in 14 of 148 healthy term infants born from 5 to 18 February 2019; 12 babies were re-hospitalized with LRTI and recovered in a few days. In 6 infants the RSV-PCR was positive, in the others, RSV etiology was suggested due to similar symptoms and contact between them.The first NICU-patient with RSV-LRTI was a 26 gestational weeks (GW) twin with BPD. From 19 February to 15 March 26 babies, 26-34 GW at birth were tested for RSV (33 nasal/throat swabs). They received a first or subsequent palivisumab-injection. We identified 11 positive samples in 7 of the babies. Six of them were with symptoms of LRTI, two needed mechanical ventilation. In 4 babies despite the recovery, the second RSV-PCR remained positive. After stabilization 6 babies were discharged home, one was transferred to the Paediatric department for further treatment of BPD. Conclusions: The reported outbreak of RSV-infections in neonates was the most serious since the RSV-PCR diagnostic in Bulgaria was introduced. The course of RSV-LRTI was severe in extremely preterm newborns with underlying BPD. So routine in-hospital RSV-prophylaxis with palivizumab should be considered for infants at the highest risk.
Different Gastrointestinal Microbiota Related to Bile-Acid Metabolism in Hypertensive Patients With or Without Nephropathy
Authors: LI XIN , WANG LI , MA SHAOJUN , LIN SHAOHUI , WANG CHUNYAN , WANG HAIYA 
Published: January 2021

Abstract
Background: The human microbiome is a mixed group of microorganisms and has been verified the relationship between gastrointestinal microbiota and blood pressure. The intestinal microbiota of chronic kidney disease (CKD) patients in the distribution of bacterial species is different from the flora of people with no CKD. The purpose of this research is to study on the different intestinal microbiota of hypertensive patients with and without nephropathy and to find possible bio-markers to diagnose hypertensive nephropathy, as well as one of the basis for hypertensive nephropathy or CKD clinical intervention treatment.

Methods: The study subjects were divided into three groups, normal control, simple hypertension and hypertensive nephropathy. Sequencing, bioinformatics and statistical analysis were performed on the 16S rRNA gene of the flora of the subjects' stool samples.

Results: This research shows the difference of intestinal flora in hypertension patients with and without nephropathy; it investigates the relationship of the differences in the intestinal microbiota with bile-acid metabolism; it also explores bile-acid metabolism mechanism of intestinal microbiota differences of hypertensive with or without nephropathy.

Conclusions: The different gastrointestinal microbiota is related to bile-acid metabolism in hypertensive patients, and can be one of the factors causing CKD.

Trial registration: This article does not report the results of a health care intervention on human participants.
Antibiotic Resistance and Virulence Profiles of Gram-Negative Bacteria Isolated from Loggerhead Sea Turtles (Caretta Caretta) of the Island of Maio, Cape Verde
Authors: Fernandes Matilde Costa , Grilo Miguel L. , Cunha Eva , Carneiro Carla , Tavares Luís , Patino-Martinez Juan , Oliveira Manuela 
Published: January 2021

Abstract

Background: Several studies detected high levels of antibiotic-resistance in loggerhead sea turtles (Caretta caretta) and pointed this species as prime reservoirs of antibiotic-resistant bacteria and carriers of potentially pathogenic bacteria. This study aimed to characterize, for the ﬁrst time, the Gram-negative aerobic microbiota of the Cape Verdean loggerhead subpopulation. Cloacal, oral and egg content swab samples from 33 nesting loggerheads (n = 99) of the Island of Maio were analysed regarding the presence of Gram-negative bacteria and their antibiotic resistance and virulence proﬁles. Results: Shewanella putrefaciens (27.78%), Morganella morganii (22.22%) and Vibrio alginolyticus (22.22%) were the most prevalent species isolated from the animals under study. A low incidence of antibiotic-resistant bacteria (26%) was detected, and no multidrug-resistant isolates were identiﬁed. Non-Enterobacteriaceae isolates presented the most complex virulence proﬁles, revealing the ability to produce hemolysins (100%), DNases (89%), lipases (79%), proteases (53%), lecithinases (21%), gelatinases (16%), and also bioﬁlms (74%). Moreover, higher virulence indices were obtained for turtles with high parasite intensities compared with apparently healthy animals, and a positive correlation between antibiotic resistance and virulence was observed. Conclusions: Results suggest that this loggerhead population may be less exposed to antimicrobial compounds, probably due to the low anthropogenic impact observed in both their nesting (the Island of Maio) and foraging sites. Nevertheless, the presence of potentially pathogenic bacteria expressing virulence factors may threat both sea turtles’ and humans’ health.