bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unitarity of entanglement and islands in two-sided Janus black holes
Authors: Bak Dongsu , Kim Chanju , Yi Sang-Heon , Yoon Junggi 
Published: January 2021

Abstract
We explore the entanglement evolution of boundary intervals in eternal Janus black holes that can be embedded consistently into string theory in the low-energy limit. By studying the geodesics we show that there is a transition in the entanglement characteristic around the Page time, which manifests the unitarity of the evolution. We reproduce and reinterpret these bulk results from two different lower-dimensional perspectives: first as an interface CFT in the usual AdS/CFT correspondence and second as an effective gravity theory in one lower dimension coupled to a radiation background. In the limit where the number of interface degrees of freedom becomes large, we obtain an effective theory on appropriate branes that replace the deep interior region in the bulk, coined the shadow region. In this effective theory, we also identify the island of the radiation entanglement wedge and verify the newly proposed quantum extremization method. Our model clarifies that double holography with gravity in two higher dimensions can be realized in a concrete and consistent way and that the occurrence of islands is natural in one higher dimension. Furthermore, our model reveals that there can be a transitional behavior of the Page curve before the Page time, which is related to the emergence of new matter degrees of freedom on the branes.
Bone cement implantation syndrome in cemented hip hemiarthroplasty—a persistent risk
Authors: Weingärtner Karoline , Störmann Philipp , Schramm David , Wutzler Sebastian , Zacharowski Kai , Marzi Ingo , Lustenberger Thomas 
Published: January 2021

Abstract
Background
Every year, ~ 210,000 initial implantations of hip endoprostheses are carried out in Germany alone. The “bone cement implantation syndrome” (BCIS) is considered a severe peri- and early-postoperative complication when implanting cemented prostheses. The origin of the BCIS and its impact on the clinical outcome are still uncertain. This study investigates the clinical progression after BCIS cases in patients with cemented hemiarthroplasty. Risk factors for the occurrence of BCIS are evaluated.

Material and methods
Clinical data of all patients with a proximal femur fracture and which received a cemented hemiarthroplasty within a period of 9.5 years have been collected. BCIS (+) patients and BCIS (−) patients were compared with respect to their demographics and clinical outcome. Risk factors for the development of BCIS were identified.

Results
A total of 208 patients could be included with complete data sets. The mean age was 81.1 ± 10.0 years. Overall, 37% of the patients showed symptoms of BCIS. In comparison to BCIS (−) patients there was a significantly higher rate of cardiovascular complications (27.3% vs. 13.7%, p = 0.016) and a higher in-hospital mortality rate (15.6% vs. 4.6%, p = 0.006) in BCIS (+) patients. Age, absence of a femoral borehole and ASA status were identified as statistically significant risk factors of BCIS.

Conclusion
BCIS is frequently observed and in some cases severe complication. The therapy is exclusively symptomatic; identifying preventional measures might reduce the occurrence of BCIS.
Sexueller Missbrauch Pflegebedürftiger
Authors: Moser Fabian , Schütz Leonhard H. , Teubner Christian , Lahmann Nils , Kuhlmey Adelheid , Suhr Ralf 
Published: January 2021

Zusammenfassung
Hintergrund
Gewalt gegen pflegebedürftige ältere Menschen ist häufig. Hausärzte/-ärztinnen können bei der Prävention von Gewalt eine Rolle spielen. Insbesondere sexualisierte Gewalt ist stark tabuisiert und wenig untersucht.

Ziel der Arbeit
Ziel dieser Arbeit ist es, die Einstellung von Hausärzten/-ärztinnen zu ihrer Verantwortung bei sexuellem Missbrauch pflegebedürftiger Patienten/Patientinnen zu untersuchen. Zugleich sollen die subjektive Sicherheit hinsichtlich des Vorgehens bei einem Missbrauchsverdacht sowie die Fortbildungsinteressen von Hausärzten/-ärztinnen zum Thema erhoben werden.

Material und Methoden
In einer Querschnittsstudie wurden 1700 Hausärzte/-ärztinnen in Deutschland zwischen September und November 2016 schriftlich befragt. Fragebogen von 302 Ärzten/Ärztinnen konnten ausgewertet werden.

Ergebnisse
Die Unsicherheit hinsichtlich des weiteren Vorgehens bei Verdacht auf sexuellen Missbrauch von pflegebedürftigen Patienten/Patientinnen ist groß. Nahezu alle Befragten sehen es als Teil der ärztlichen Verantwortung, bei sexuellem Missbrauch pflegebedürftiger Patienten/Patientinnen zu intervenieren. Hauptsächliches Fortbildungsinteresse besteht zur Differenzialdiagnose des sexuellen Missbrauchs sowie zum richtigen Vorgehen im Verdachtsfall.

Schlussfolgerung
Fortbildungen, insbesondere zu den Anzeichen sexueller Gewalt gegen Pflegebedürftige, können einen Beitrag leisten, die Handlungssicherheit von Hausärzten/-ärztinnen zu stärken und ihre Bereitschaft zur Prävention zu erhöhen.
Effect of corpus callosum agenesis on the language network in children and adolescents
Authors: Bartha-Doering Lisa , Schwartz Ernst , Kollndorfer Kathrin , Fischmeister Florian Ph. S. , Novak Astrid , Langs Georg , Werneck Harald , Prayer Daniela , Seidl Rainer , Kasprian Gregor 
Published: January 2021

AbstractThe present study is interested in the role of the corpus callosum in the development of the language network. We, therefore, investigated language abilities and the language network using task-based fMRI in three cases of complete agenesis of the corpus callosum (ACC), three cases of partial ACC and six controls. Although the children with complete ACC revealed impaired functions in specific language domains, no child with partial ACC showed a test score below average. As a group, ACC children performed significantly worse than healthy controls in verbal fluency and naming. Furthermore, whole-brain ROI-to-ROI connectivity analyses revealed reduced intrahemispheric and right intrahemispheric functional connectivity in ACC patients as compared to controls. In addition, stronger functional connectivity between left and right temporal areas was associated with better language abilities in the ACC group. In healthy controls, no association between language abilities and connectivity was found. Our results show that ACC is associated not only with less interhemispheric, but also with less right intrahemispheric language network connectivity in line with reduced verbal abilities. The present study, thus, supports the excitatory role of the corpus callosum in functional language network connectivity and language abilities.
Human olfactory dysfunction: causes and consequences
Authors: Schäfer Laura , Schriever Valentin A. , Croy Ilona 
Published: January 2021

AbstractThe sense of smell essentially contributes to social communication, guides nutrition behaviour and elicits avoidance towards environmental hazards. Olfactory smell impairment may hence entail severe consequences for affected individuals. Compared with sensory loss in other modalities, reduced olfactory function is often unnoticed by those affected and diagnosed late. Those patients seeking help frequently suffer from long-term impairments resulting in reduced well-being and quality of life. The current review provides an overview of aetiology, prevalence and specifics of diagnostics in acquired and congenital olfactory loss and focusses on short- and long-term consequences. Compensation strategies are elaborated, and treatment options are mentioned. Individual characteristics associated with the development of serious mental health impairment are discussed in order to help practitioners identifying populations at risk.
COVID-19 and the Growth Potential
Authors: Grömling Michael 
Published: January 2021

AbstractThe lasting economic impact of the coronavirus pandemic will become apparent in the development of the macroeconomic factors of production — labour, capital, human capital as well as the stock of technical knowledge. Changes in behaviour such as a greater acceptance of technology can strengthen potential output permanently. By contrast, negative effects may arise from growing protectionist attitudes or long-lasting uncertainties and ‘scarring effects’. In any case, the coronavirus crisis has induced a technology push. This may be intensified if digitisation gains additional support from investments in infrastructure or if the pandemic heralds a renaissance in the natural sciences — with a corresponding impact on human and physical capital as well as on technical knowledge. For the time being, it is unclear what effects the restructuring and secular structural change will have on potential output. However, dangers are lurking in the acceleration of geopolitical tensions, a misunderstanding of technological sovereignty and increasing government interventions, which, as a whole, could hamper innovation and investment.
Molecular mechanism underlying Pyropia haitanensis PhHsp22-mediated increase in the high-temperature tolerance of Chlamydomonas reinhardtii
Authors: Chang Jing , Shi Jianzhi , Lin Jianzhang , Ji Dehua , Xu Yan , Chen Changsheng , Wang Wenlei , Xie Chaotian 
Published: January 2021

AbstractGlobal warming is one of the key limiting factors affecting the cultivation of Pyropia haitanensis which is an economically important macroalgae species grown in southern China. However, the mechanism underlying the high-temperature tolerance of P. haitanensis remains largely unknown. In a previous study, we showed that the expression of the small heat shock protein 22 gene (Hsp22) is upregulated in P. haitanensis in response to high-temperature stress, but the associated regulatory mechanism was not fully elucidated. In this study, a transgenic Chlamydomonas reinhardtii expression system was used to functionally characterize P. haitanensis Hsp22. Our analyses indicated that the C-terminal of PhHsp22 is highly conserved and contains an A-crystal structure domain. A phylogenetic analysis revealed PhHsp22 is not closely related to small heat shock protein genes in other species. Additionally, PhHsp22 expression significantly increased at 3 and 6 h after initiating 33 °C treatment, which improved the survival rate of transgenic C. reinhardtii during the early stage of high-temperature treatment. The further transcriptome analysis revealed that PhHsp22 expression can promote pathways related to energy metabolism, metabolites metabolism, and protein homeostasis in transgenic C. reinhardtii cells exposed to high temperatures. Therefore, PhHsp22 may be crucial for the response of Pyropia species to high-temperature stress. Furthermore, this gene may be useful for breeding new high-temperature algal strains.
Comparison of Accu Chek Inform II point-of-care test blood glucose meter with Hexokinase Plasma method for a diabetes mellitus population during surgery under general anesthesia
Authors: Lascaris B. , Freling H. G. , Edens M. A. , Fokkert M. J. , Olthof C. G. , Slingerland R. J. 
Published: January 2021

Abstract
Purpose
Blood glucose (BG) concentrations of patients with diabetes mellitus (DM) are monitored during surgery to prevent hypo- and hyperglycemia. Access to point-of-care test (POCT) glucose meters at an operating room will usually provide monitoring at shorter intervals and may improve glycemic control. However, these meters are not validated for patients under general anesthesia.

Methods
This cross-sectional study included 75 arterial BG measurements from 75 patients (71 with DM, mostly insulin dependent) who underwent elective non-cardiac surgery under general anesthesia. Arterial blood samples were taken at least 60 minutes after induction. One drop of blood was used for Accu Chek Inform II (ACI II) POCT BG meter and the residual blood was sent to the clinical laboratory for a Hexokinase Plasma reference method. A Bland–Altman plot was used to visualize the differences between both methods, and correlation was assessed using the intra-class correlation coefficient (ICC).

Results
The results showed an estimated mean difference of 0.8 mmol/L between ACI II and the reference method, with limits of agreement equal to -0.6 and 2.2 mmol/L. In general, the reference method produced higher values than ACI II. ICC was 0.955 (95% CI 0.634–0.986), P < 0.001, and concordance correlation coefficient (CCC) was 0.955 (95% CI 0.933–0.970).

Conclusion
Arterial BG measurements during surgery in patients with DM under general anesthesia using POCT BG meter are in general lower than laboratory measurements, but the ICC and CCC show a clinically acceptable correlation. We conclude that POCT measurements conducted on arterial specimens using the ACI II provide sufficiently accurate results for glucose measurement during surgery under general anesthesia.
The Mindful Hedonist? Relationships between Well-Being Orientations, Mindfulness and Well-Being Experiences
Authors: Richter Nadine , Hunecke Marcel 
Published: January 2021

AbstractOrientations to well-being, including personal values, motives and goals regarding one’s well-being are often related to the experience of well-being. At the same time, studies show positive effects of mindfulness on well-being. It is conceivable, that the strength of the connection between well-being orientations and experiences depend on the degree of dispositional mindfulness. To explore relationships between orientations and experiences of well-being as well as the potential moderation effect of mindfulness, two cross-sectional online studies with German-speaking participants were conducted. In Study 1 (N = 414) mindfulness moderated the relationship between life of pleasure (measured by the Orientations to Happiness Scale) and life satisfaction (β = −0.10, p = 0.017) as well as the relationship between life of meaning (β = −0.10, p = 0.028). As hypothesized, mindfulness moderated the connection between life of engagement and life satisfaction (β = −0.14, p = 0.001) as well as the negative relationship between search for meaning and life satisfaction (β = 0.15, p < 0.001). In Study 2 (N = 731) none of those effects were statistically replicated. Yet, mindfulness moderated the relationship between hedonia (measured by the Hedonic and Eudaimonic Motives for Action Questionnaire) and life satisfaction (β = −0.07, p = 0.048) as well as the relationship between search for meaning and psychological well-being (β = 0.07, p = 0.015). Overall, the results show that mindfulness has no substantial moderating effect on the well-being orientations and experiences relationship. Yet, in both studies, mindfulness and well-being orientations were consistently related to well-being experiences. This points out, that both are related to the experience of well-being, but beyond that not as interacting factors.
The rule of rules
Authors: Hamlin Alan 
Published: January 2021

AbstractRules are central to the constitutional political economy (CPE) approach. On this approach, rules, of a variety of types and forms, are necessary for the emergence of a political and social order, so that all genuine political order is rule-based. The central role of rules within the CPE approach is examined starting from an explicit definitional discussion of the concept of a rule and including discussion of the nature of rule-following behavior, the supply of rules, and rule enforcement.
Development of an EORTC questionnaire measuring instrumental activities of daily living (IADL) in patients with brain tumours: phase I–III
Authors:   on behalf of the EORTC Quality of Life Group, Oort Quirien , Dirven Linda , Sikkes Sietske A. M. , Aaronson Neil , Boele Florien , Brannan Christine , Egeter Jonas , Grant Robin , Klein Martin , Lips Irene , Narita Yoshitaka , Sato Hitomi , Sztankay Monika , Stockhammer Günther , Talacchi Andrea , Uitdehaag Bernard M. J. , Reijneveld Jaap C. , Taphoorn Martin J. B. 
Published: January 2021

Abstract
Purpose
Being able to function independently in society is an important aspect of quality of life. This ability goes beyond self-care, requires higher order cognitive functioning, and is typically measured with instrumental activities of daily living (IADL) questionnaires. Cognitive deficits are frequently observed in brain tumour patients, however, IADL is almost never assessed because no valid and reliable IADL measure is available for this patient group. Therefore, this measure is currently being developed.

Methods
This international multicentre study followed European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group module development guidelines. Three out of four phases are completed: phases (I) generation of items, (II) construction of the item list, and (III) pre-testing. This paper reports the item selection procedures and preliminary psychometric properties of the questionnaire. Brain tumour patients (gliomas and brain metastases), their informal caregivers, and health care professionals (HCPs) were included.

Results
Phase I (n = 44 patient-proxy dyads and 26 HCPs) generated 59 relevant and important activities. In phase II, the activities were converted into items. In phase III (n = 85 dyads), the 59 items were pre-tested. Item selection procedures resulted in 32 items. Exploratory factor analysis revealed a preliminary dimensional structure consisting of five scales with acceptable to excellent internal consistency (α = 0.73–0.94) and two single items. For three scales, patients with cognitive impairments had significantly more IADL problems than patients without impairments.

Conclusion
A phase IV validation study is needed to confirm the psychometric properties of the EORTC IADL-BN32 questionnaire in a larger international sample.
Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study
Authors: Rasmussen G. H. F. , Madeleine P. , Arroyo-Morales M. , Voigt M. , Kristiansen M. 
Published: January 2021

Abstract
Objective
Persistent pain and loss of shoulder function are common adverse effects to breast cancer treatment, but the extent of these issues in comparison with healthy controls is unclear for survivors beyond 1.5 years after treatment. The purpose of this study was to benchmark differences in pressure pain thresholds (PPT), maximal isokinetic muscle strength (MIMS), and active range of motion (ROM) of females with persistent pain ≥1.5 years after breast cancer treatment (BCS) compared with pain-free matched controls (CON), and examine the presence of movement-evoked pain (MEP) during assessment of MIMS.

Methods
The PPTs of 18 locations were assessed using a pressure algometer and a numeric rating scale was used to assess intensity of MEP. Active ROM and MIMS were measured using a universal goniometer and an isokinetic dynamometer, respectively.

Results
A two-way analysis of variance revealed that PPTs across all locations, MIMS for horizontal shoulder extension/flexion and shoulder adduction, active ROM for shoulder flexion, horizontal shoulder extension, shoulder abduction, and external shoulder rotation were significantly lower for BCS compared with CON (P < 0.05). MEP was significantly higher for BCS and MEP intensity had a significant, negative correlation with PPTs (P < 0.01).

Discussion/conclusion
BCS with persistent pain ≥1.5 years after treatment demonstrates widespread reductions in PPTs and movement-specific reductions in MIMS and active ROM of the affected shoulder, along with MEP during physical performance assessment.

Implications for cancer survivors
BCS with persistent pain ≥1.5 years after treatment shows signs of central sensitization and may benefit from individualized rehabilitation.
Does physical appearance perfectionism predict disordered dieting?
Authors: Czepiel Diana , Koopman Hendricus M. 
Published: January 2021

AbstractDespite that disordered eating has been repeatedly associated with perfectionism, the results are inconsistent as to which exact dimensions of perfectionism it is related to. Moreover, the increasing evidence that perfectionism is best conceptualized as a domain-specific, as opposed to a global, trait contribute to the lack of clarity. Therefore, the aim of this study was to examine which dimensions of global and physical appearance perfectionism statistically predict disordered dieting in a non-clinical adult female sample. In total 437 participants completed the Short Almost Perfect Scale, which distinguishes between adaptive and maladaptive perfectionism, the Physical Appearance Perfectionism Scale, which distinguishes between hope for perfection and worry about imperfection, and the Dieting subscale of the Eating Attitudes Test-26. A hierarchical regression analysis revealed that only maladaptive, as opposed to adaptive, global perfectionism statistically predicted disordered dieting. Furthermore, both dimensions of physical appearance perfectionism statistically predicted disordered dieting, although worry about imperfection, its maladaptive dimension, was the strongest statistical predictor. The present results demonstrate that worry about imperfection is an effective statistical predictor of disordered dieting among women, possibly serving as a starting point for further research investigating the utility of its incorporation in prevention and treatment protocols for disordered eating.
Stapler-less burst pressure in an ex vivo human gastric tissue: a randomized controlled trial
Authors: del Genio Gianmattia , Gambardella Claudio , Tolone Salvatore , Brusciano Luigi , Parmeggiani Domenico , Lanza Volpe Mariachiara , Lucido Francesco Saverio , Docimo Ludovico 
Published: January 2021

AbstractStapler-less laparoscopic sleeve gastrectomy (LSG) is emerging as a new potential affordable cost-effective alternative procedure. However, no pre-clinical data are currently available on human tissue. We aimed to evaluate whether traditionally suturing without the use of surgical stapling may produce a comparable bursting pressure on human gastric tissue. A prospective cohort of consecutive patients undergoing LSG was divided in two groups to compare a barbed extra-mucosal running suture (stapler-less) versus a standard stapler line. A burst pressure test was applied to the gastric specimen employing high-resolution manometric catheter. Type, location and features of the leak were described. We enrolled a total of 40 obese patients, 20 patients for each group. Median burst pressures of the stapler-less group resulted statistically significant increased (p < 0.0001) than the one in standard stapler group. In all cases, leak occurred along the surgical closure site independently from the used technique (group 1 vs 2; p = N.S.), more often at the proximal stomach (p < 0.05). In human ex vivo model, traditional surgical suture (i.e. running hand-sewn) produced an effective temporary closure, with superior resistance to increasing volume and pressure. How this may impact on clinical LSG outcomes needs further evaluations and was not the object of this study.
Rekurrenz – Evokation – Konnotation: Bausteine für eine strukturalistische Analyse literarischer Texte
Authors: Knobloch Clemens 
Published: January 2021

ZusammenfassungÜber welche theoretischen und methodologischen Ressourcen verfügt ein (strukturalistisch sozialisierter) Linguist für die Analyse dessen, was einen literarischen Text ausmacht? Von zwei Gesichtspunkten her geht der Beitrag dieser Frage nach: Einmal von Eugenio Coserius textlinguistischer Reflexion der Besonderheiten von Literatur, mit dem Schwerpunkt auf geordneter Rekurrenz von Elementen in allen Ebenen, und zum anderen von den Theorien des US-Sprachphilosophen und Literaturkritikers Kenneth Burke. Illustriert werden die Deutungsverfahren an Beispielen aus Lyrik und Prosa.