bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eine akute Fazialisparese als mögliche Impfkomplikation bei einer Impfung gegen SARS-CoV-2
Authors: Volk Gerd Fabian , Kuttenreich Anna-Maria , Geitner Maren , Guntinas-Lichius Orlando 
Published: May 2021

ZusammenfassungObwohl die akute Fazialisparese (akute Gesichtsnervenlähmung, Bell-Lähmung) als mögliche Impfkomplikation auf eine Impfung gegen SARS-CoV-2 explizit im Aufklärungsmerkblatt der Impfstoffe erwähnt wird, überwiegt aus unserer Sicht klar der Nutzen der Impfung gegenüber möglichen Risiken. Aus den bisherigen Fallbeschreibungen lässt sich allenfalls, wenn überhaupt, ein gering erhöhtes Risiko ableiten. Das Risiko einer akuten Fazialisparese ist im Zusammenhang mit vielen Impfungen beschrieben; das Risiko scheint, wenn vorhanden, kein spezifisches Risiko zu sein. Andererseits sind auch Fälle von akuter Fazialisparese unter einer COVID-19-Erkrankung beschrieben, sodass sich die theoretische Frage stellt, inwieweit die Impfung möglicherweise eher das Auftreten einer Fazialisparese verhindert als befördert. Schlussendlich lässt sich die akute Fazialisparese, wenn schnell gehandelt wird, gut therapieren und ist von der Schwere und Folgeerscheinungen nicht mit der Krankheitsschwere und den möglichen Folgeerscheinungen einer COVID-19-Erkrankung zu vergleichen.
Surgery for Pulmonary Metastases: Long-Term Survival in 281 Patients
Authors: Dudek Wojciech , Schreiner Waldemar , Haj Khalaf Mohamed , Sirbu Horia 
Published: May 2021

Abstract
Background Despite weak evidence, pulmonary metastasectomy (PM) is widely performed with intent to improve patient survival. Our single-institution analysis aims to evaluate outcomes and to identify factors influencing survival of patients undergoing PM for metastases from wide range of primary tumors.
Materials and Methods All patients undergoing curative-intent PM between 2008 and 2018 were retrospectively analyzed. The impact of factors related to primary tumor, metastases, and associated therapy on overall survival (OS) was evaluated using univariable and multivariable Cox proportional hazard models. Cutoff values of continuous variables were determined by a receiver operating characteristic analysis.
Results In this study, 281 patients (178 male, median age 61 years) underwent PM. Two (0.7%) perioperative deaths and 23 (8.2%) major complications occurred. Median interval between the treatment of primary tumor and PM was 21 months. Median size of largest metastasis was 1.4 cm. After the median follow-up of 29 months, 134 patients (47.7%) had died. Five-year OS rate after first PM was 47.1%. Complete resection was achieved in 274 (97.5%) patients. Multivariable analysis identified genitourinary origin (hazard ratio [HR]: 0.30, 95% confidence interval [CI]: 0.15–0.60, p = 0.0008) as independent positive survival prognosticator; incomplete resection (HR: 3.53, 95% CI: 1.40–8.91, p = 0.0077) and age at PM of ≥66 years (HR: 1.97, 95% CI: 1.36–2.85, p = 0.0003) were negative prognosticators.
Conclusion The use of PM as a part of multimodal treatment is in selected population justified. Our analysis identified age, primary tumor origin, and completeness of resection as independent survival prognosticators.
Endoscopic-Assisted Microsurgical Resection of Right Recurrent Meckel's Cave Meningioma Extended to Cavernous Sinus
Authors: Fava Arianna , di Russo Paolo , Giammattei Lorenzo , Froelich Sébastien 
Published: May 2021

Abstract
Objective This study was aimed to present the complete removal of a large recurrent Meckel's cave meningioma.
Design This study is a case report.
Setting The study was conducted at Department of Neurosurgery and Skull Base Laboratory at Lariboisiére Hospital, Paris.
Participant A 53-year-old male was presented with a severe V1, V2, and V3 hypoesthesia and pain. He was operated 7 years ago for a right Meckel's cave meningioma with postoperative V1–V2 hypoesthesia. Magnetic resonance imaging (MRI) showed a large tumor recurrence extending into the cavernous sinus (CS), posterior fossa (PF), sphenoid sinus (SS), pterygopalatine (PPF), and infratemporal fossa (ITF; Fig. 1).
Main Outcome Measures Radiological results and postoperative course were assessed for this study.
Results The previous right frontotemporal approach was used. The lateral wall of the orbit, the middle fossa floor and the anterior temporal base were drilled to expose the orbit, PPF, and ITF. Foramen ovale (FO), foramen rotondum (FR), and superior orbital fissure (SOF) were opened. The meningoorbital band was cut and the lateral wall of CS was elevated (Fig. 2). The inferior orbital fissure was opened and tumor removed into the ITF, PPF, and orbit. After entering Meckel's cave from above, tumor was removed from PF. After microsurgical tumor removal, a 45-degree endoscope was used to remove tumor remnant and mucosa into SS. A watertight dural closure with pericranium was performed, reinforced with autologous fat and fibrin glue. Postoperative MRI showed complete tumor resection (Fig. 1). The patient experienced a right-side keratitis that resolved within 10 days and a V3 hypoesthesia that improved at 2 months.
Conclusion This surgical case shows how the anatomical knowledge is mandatory in skull base surgery and how the integration of microsurgical and endoscopic-assisted techniques allows to obtain optimal results.The link to the video can be found at: https://youtu.be/qxt_389AdWU.
Efficacy of Handpiece Mounted Continuous Irrigation System for the Removal of Residual Pulpal Debris During Root Canal Preparation
Authors: Sarwar Huma , Qazi Fazal , Ahmed Shahbaz , Abidi Yawar , Naeem Meshal , Shabbir Juzer , Khurshid Zohaib 
Published: May 2021

Abstract
Objective The removal of residual pulpal debris (RPD) from the root canal walls, especially in necrotic teeth is important for successful endodontic outcome. The aim of this study was to evaluate the RPD removal efficacy of handpiece mounted continuous irrigation with simultaneous root canal preparation from the apical third of root canals as compared to conventional syringe irrigation (SI).
Materials and Methods Ninety extracted teeth were randomly divided into three groups: SI; handpiece mounted continuous irrigation (CI); and both syringe and continuous irrigation (CI+SI). After root canal preparation, roots were sectioned at 1 (a), 3 (b) and 5 (c) mm from apex and prepared for Hematoxylin-Eosin staining. Sections were microscopically examined for presence of RPD.
Statistical Analysis Intergroup difference in average percentage of RPD at different root levels was calculated by using analysis of variance test (ANOVA). Tuckey test was used for pairwise comparison.
Results ANOVA showed significant difference between all three groups (p < 0.05). SI group showed a significantly higher percentage of RPD as compared with CI and CI+ SI groups at all root levels (p < 0.01). At root level a, CI showed a significantly higher percentage of RPD as compared with CI+SI (p < 0.01).
Conclusion Handpiece mounted CI during rotary instrumentation showed a significant reduction in RPD as compared with conventional syringe irrigation. This technique was found to be an effective method for an enhanced root canal debridement.
Evidence-Based Health Informatics as the Foundation for the COVID-19 Response: A Joint Call for Action
Authors: Fernandez-Luque Luis , Kushniruk Andre W. , Georgiou Andrew , Basu Arindam , Petersen Carolyn , Ronquillo Charlene , Paton Chris , Nøhr Christian , Kuziemsky Craig E. , Alhuwail Dari , Skiba Diane , Huesing Elaine , Gabarron Elia , Borycki Elizabeth M. , Magrabi Farah , Denecke Kerstin , Peute Linda W. P. , Topaz Max , Al-Shorbaji Najeeb , Lacroix Paulette , Marcilly Romaric , Cornet Ronald , Gogia Shashi B. , Kobayashi Shinji , Iyengar Sriram , Deserno Thomas M. , Mettler Tobias , Vimarlund Vivian , Zhu Xinxin 
Published: May 2021

Abstract
Background As a major public health crisis, the novel coronavirus disease 2019 (COVID-19) pandemic demonstrates the urgent need for safe, effective, and evidence-based implementations of digital health. The urgency stems from the frequent tendency to focus attention on seemingly high promising digital health interventions despite being poorly validated in times of crisis.
Aim In this paper, we describe a joint call for action to use and leverage evidence-based health informatics as the foundation for the COVID-19 response and public health interventions. Tangible examples are provided for how the working groups and special interest groups of the International Medical Informatics Association (IMIA) are helping to build an evidence-based response to this crisis.
Methods Leaders of working and special interest groups of the IMIA, a total of 26 groups, were contacted via e-mail to provide a summary of the scientific-based efforts taken to combat COVID-19 pandemic and participate in the discussion toward the creation of this manuscript. A total of 13 groups participated in this manuscript.
Results Various efforts were exerted by members of IMIA including (1) developing evidence-based guidelines for the design and deployment of digital health solutions during COVID-19; (2) surveying clinical informaticians internationally about key digital solutions deployed to combat COVID-19 and the challenges faced when implementing and using them; and (3) offering necessary resources for clinicians about the use of digital tools in clinical practice, education, and research during COVID-19.
Discussion Rigor and evidence need to be taken into consideration when designing, implementing, and using digital tools to combat COVID-19 to avoid delays and unforeseen negative consequences. It is paramount to employ a multidisciplinary approach for the development and implementation of digital health tools that have been rapidly deployed in response to the pandemic bearing in mind human factors, ethics, data privacy, and the diversity of context at the local, national, and international levels. The training and capacity building of front-line workers is crucial and must be linked to a clear strategy for evaluation of ongoing experiences.
Trevino and Doh’s discourse-based view: Do we need a new theory of internationalization?
Authors: Ault Joshua K , Newenham-Kahindi Aloysius , Patnaik Sanjay 
Published: May 2021

AbstractThis counterpoint examines the relevance of Trevino and Doh’s proposed new discourse-based view of internationalization for the field of International Business (IB). Trevino and Doh introduce their framework to address gaps in Internationalization Process Theory (IPT), which does not account for the underlying processes that lead to the initial managerial decision to internationalize. Framing our counterpoint around recent debates on how interdisciplinary research fields determine which new ideas to adopt, we explore whether the introduction of the discourse-based view adds sufficient novelty to justify the risk of fragmentation within IB. To stimulate debate around this question, we explore a number of issues, such as (1) whether the constructs found in the discourse-based view are distinct from pre-existing IB concepts, (2) the relative value of isolating the initial decision to internationalize within the broader internationalization process, and (3) the degree to which Trevino and Doh have isolated discourse as a primary mechanism driving the decision to internationalize. We conclude with a call for more dialog around the questions of how IB can embrace greater openness while still maintaining coherence and advancing collective knowledge.
Study of the radioactive contamination of the ion source complex in the Selective Production of Exotic Species (SPES) facility
Authors: Centofante L. , Donzella A. , Zenoni A. , Ferrari M. , Ballan M. , Corradetti S. , D’Agostini F. , Lilli G. , Manzolaro M. , Monetti A. , Morselli L. , Scarpa D. , Andrighetto A. 
Published: May 2021

The Isotope Separation On-Line (ISOL) technique is today established as one of the primary methods to produce high-intensity and high-quality radioactive beams. This technique produces, for a given amount of the desired isotope, many orders of magnitude of other radioactive species. Due to the activation generated by interactions of the primary beam, intense neutron fields, and deposition of the produced radioactive ions inside beam line elements, an ISOL facility in operation becomes an intense radioactive source. Therefore, the biological hazard imposes severe radiological safety challenges to the design, operation, maintenance, and final decommissioning of such facilities. A challenging component is the ion source complex, where the ion extraction electrode provides the extraction of radioactive ions from the ion source and the first acceleration to the extracted beam. The radioactive contamination of this sub-component is studied, by means of the FLUKA code, in the case of the Selective Production of Exotic Species facility, which is in the advanced construction phase at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Padua, Italy. The developed model includes isotope production by the interactions of a 40 MeV energy proton beam on a 238UCx target, selection of radioactive isotopes that are able to stick on the electrode tip, time evolution of the deposited isotopes during the operation and cooling periods before maintenance interventions, and evaluation of the ambient dose equivalent rate generated by the contamination of the electrode tip. Based on these results, the possibility of manual interventions for maintenance and emergency vs the use of remote handling systems is discussed.
Persulfidation of ATG18a regulates autophagy under ER stress inArabidopsis
Authors: Aroca Angeles , Yruela Inmaculada , Gotor Cecilia , Bassham Diane C. 
Published: May 2021

SignificanceEndoplasmic reticulum (ER) stress is a condition triggered by adverse environmental conditions, which in plants include extreme heat, pathogen infection, and drought. These stresses can have a devastating effect on agricultural productivity, and the appropriate responses of plants to stress are therefore critical. Autophagy is a macromolecular degradation pathway that is activated in response to stress, including ER stress, but the mechanism by which it is regulated is still unclear. Here, we describe a modification, persulfidation, of the key autophagy protein ATG18a that affects its binding to membranes and controls its activity. This tight regulation of autophagy therefore allows plants to control the tradeoff between growth and stress tolerance.
Bilin-dependent regulation of chlorophyll biosynthesis by GUN4
Authors: Zhang Weiqing , Willows Robert D. , Deng Rui , Li Zheng , Li Mengqi , Wang Yan , Guo Yunling , Shi Weida , Fan Qiuling , Martin Shelley S. , Rockwell Nathan C. , Lagarias J. Clark , Duanmu Deqiang 
Published: May 2021

Significance
Enzymes of the chlorophyll biosynthetic pathway, which bind protoporphyrin and Mg-porphyrins, are susceptible to damage by singlet oxygen production in the presence of light and oxygen. These studies show that heme-derived linear tetrapyrroles (bilins) both stimulate and protect the protoporphyrin-binding CHLH subunit of Mg chelatase, the first committed enzyme of the chlorophyll synthesis, from self-sensitized photodamage and turnover via formation of nonphotosensitizing GENOMES UNCOUPLED 4 (GUN4):bilin:porphyrin adducts, which deliver protoporphyrin to CHLH. GUN4:bilin adducts likely evolved to sustain chlorophyll biosynthesis in an oxic world, accounting for retention of bilin synthesis in nearly all oxygenic photosynthetic species on Earth.
Effects of relative permittivity on primary and secondary streamers in atmospheric pressure dielectric barrier discharge
Authors: Yoshida Keigo , Komuro Atsushi , Ando Akira 
Published: May 2021

Abstract
In this study, a two-dimensional simulation of atmospheric-pressure streamer discharge with a dielectric on the cathode was conducted to investigate the effects of relative permittivity on primary and secondary streamer characteristics. An electrode configuration with an air gap of 0.1 mm was employed. The input parameters of the simulations were the relative permittivity, dielectric thickness, and applied voltage, which were summarised with five simulation conditions. The propagation velocity and electric field strength of the primary streamer mostly depended on the initial electric field applied between the anode and the dielectric surface, which is determined by the relative permittivity, dielectric thickness, and applied voltage. Conversely, the length and electric field strength of the secondary streamer depended on the amount of charge supplied by the primary streamer and the capacitance of the dielectric, which is defined by the relative permittivity and dielectric thickness.
Mixed Mott–Hubbard and charge transfer nature of 4H–SrMnO3 thin film on Si (100)
Authors: Mandal Arup Kumar , Jana Anupam , Chowdhury Sourav , Tiwari Achyut , Choudhary R J , Phase D M 
Published: May 2021

Abstract
Room temperature electronic structure of polycrystalline 4H–SrMnO3 thin film grown on Si (100) substrate has been studied using resonance photo emission spectroscopy and soft x-ray absorption spectroscopy measurements. Presence of charge transfer screen Mn 3d

n

L
final state along with the 3d
n-1 final state at the valence band edge of 4H–SrMnO3 thin film confirms that the ground state is strongly mixed between Mn 3d and O 2p states. The estimated equivalent values of on-site Coulomb interaction energy (U) and O 2p to Mn 3d- charge transfer energy (Δ) (U ≈ Δ ≈ 4.8 eV) from the combination of occupied and unoccupied spectra further confirm the intermediate Mott–Hubbard and charge transfer insulator nature of 4H–SrMnO3 film. Despite having similar Mn 4+ valence state in 4H–SrMnO3 and cubic SrMnO3, 4H phase is observed to reveal much higher band gap ∼1.5 eV than the cubic phase (0.3 eV), which arises due to different MnO6 octahedra environment.
Large-scale MoS2(1−x)Se2x
monolayers synthesized by confined-space CVD
Authors: Zhang Jinming , Qian Yezheng , Nan Haiyan , Gu Xiaofeng , Xiao Shaoqing 
Published: May 2021

Abstract
Alloy engineering is efficient in modulating the electronic structure and physical and chemical properties of Transition metal dichalcogenides (TMDs). Here, we develop an efficient and simple confined-space CVD strategy by using a smaller quartz boat nested in a larger quartz boat for the preparation of ternary alloy MoS2(1−x)Se2x
monolayers on SiO2/Si substrates with controllable composition. The effect of hydrogen ratio of the mixed carrier gas (Ar/H2) on the resultant flakes are systematically investigated. A hydrogon ratio of 15% is demonstrated to be the most appropriate to synthesize large size (more than 400 μm) single crystalline MoS2(1−x)Se2x
alloy monolayers. The composition of the alloy can also be changed in a full range (2x = 0–2) by changing the weight ratio of Se and S powder. The as-grown monolayer MoS2(1−x)Se2x
alloys present continuously high crystal quality in terms of Raman and PL measurements. Furthermore, to visible light (532 nm), the MoS2(1−x)Se2x
based photodetectors display wonderful photoresponse with a fast response of less than 50 ms. Our work may be usedful in directing the synthesis of TMDs alloys as well as their optoelectronic applications.
A novel paper biosensor based on Fe3O4@SiO2–NH2 and MWCNTs for rapid detection of pseudorabies virus
Authors: Guo Xing , Hou Jianru , Yuan Zhongyun , Li Hongmei , Sang Shengbo 
Published: May 2021

Abstract
In this study, a novel paper biosensor based on Fe3O4@SiO2–NH2 magnetic polymer microspheres and multi walled carbon nanotubes (MWCNTs) for rapid detection of pseudorabies virus (PRV) was first developed. Fe3O4@SiO2–NH2 were functionalized with PRV antibody and doped in cellulose nitrate paper to fabricate the magnetic paper biosensor with good magnetic response and biocompatibility. Using MWCNTs to build conductive network of sensors, PRV antigen binds specifically to the immunomagnetic microspheres on the sensor, and the resulting immune complex changes the magnetic domain structure of the sensor and the structural gap of MWCNTs, causing the magnetic property and impedance change. TEM and EDS characterization proved that the biosensor was successfully doped with Fe3O4@SiO2–NH2 and effectively recognized PRV. Under optimized conditions, the impedance variation was found to be linearly related to the logarithm value of PRV concentrations in the range of 10–1 mg ml−1, with the detection limit of 10 ng ml−1. This paper biosensor demonstrated advantages of portability, high sensitivity and specificity, providing a valuable method for early control of PRV.
Collapse of superradiant phase and Dicke phase transition at finite temperature in a hybrid optical-mechanical system
Authors: Huang Shan , Liu Ni , Liang J.-Q. , Li Hebin 
Published: May 2021

Abstract
In this paper, we theoretically investigate Dicke phase transition at finite temperature in a hybrid optical-mechanical system. The thermodynamic equilibrium states are presented by means of the functional path-integral approach. We plot the mean photon number of the two cavities and the corresponding phase diagram showing the effects of the coupling strength between the two cavities, the nonlinear photon-phonon interaction strength, the finite temperature, the detuning of the two cavities. The coupling strength between the two cavities can make the phase boundary of the normal phase (NP) to the superradiant phase (SP) shift left with the increase of the atom-field coupling strength. The region of the SP is suppressed completely and the SP disappears completely with the increase of the coupling strength between the two cavities or the nonlinear photon-phonon interaction strength, finally just the NP and the dynamically unstable state (DUS) exist. The nonlinear photon-phonon coupling strength just affects the turning curve, but not the phase boundary. The unstable non-zero photon number state and the SP are coexistent, similar to the optical bistability.
Particle Physics with the Cosmic Microwave Background with SPT-3G
Authors: Avva J S 
Published: May 2021

Abstract
The cosmic microwave background (CMB) encodes information about the content and evolution of the universe. The presence of light, weakly interacting particles impacts the expansion history of the early universe, which alters the temperature and polarization anisotropies of the CMB. In this way, current measurements of the CMB place interesting constraints on the neutrino energy density and mass, as well as on the abundance of other possible light relativistic particle species. We present the status of an on-going 1500 sq. deg. survey with the SPT-3G receiver, a new mm-wavelength camera on the 10-m diameter South Pole Telescope (SPT). The SPT-3G camera consists of 16,000 superconducting transition edge sensors, a 10x increase over the previous generation camera, which allows it to map the CMB with an unprecedented combination of sensitivity and angular resolution. We highlight projected constraints on the abundance of sterile neutrinos and the sum of the neutrino masses for the SPT-3G survey, which could help determine the neutrino mass hierarchy.
Analysis and Dark Matter Search Results from DEAP-3600 with 231 Live Days at SNOLAB
Authors: Westerdale S 
Published: May 2021

Abstract
DEAP-3600 is a dark matter direct detection experiment in SNOLAB (Sudbury, Canada). This single-phase detector consists of 3.3 tonnes of liquid argon, viewed by an array of 255 photomultiplier tubes through 50 cm of acrylic. The collaboration has recently released dark matter search results from the first year of running (Nov. 2016 to Oct. 2017), with a total live time of 231 days. These proceedings detail the analysis underlying these results, including the development of a background model, which constitute the most sensitive search performed with a LAr target for WIMPs with a mass greater than 30 GeV.