bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome
Authors: İremli Burçin Gönül , Şendur Süleyman Nahit , Ünlütürk Uğur 
Published: May 2021

Abstract

Context
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome) can be seen as a postvaccination phenomenon that occurs after exposure to adjuvants in vaccines that increase the immune responses. There are very limited data regarding ASIA syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

Objectives
This work aims to report cases of subacute thyroiditis related to the SARS-CoV-2 vaccine.

Methods
We describe the clinical, laboratory, and imaging features of 3 cases of subacute thyroiditis after inactivated SARS-CoV-2 vaccine (CoronaVac®). Three female healthcare workers have applied to our clinic with anterior neck pain and fatigue 4 to 7 days after SARS-CoV-2 vaccination. Two of them were in the breastfeeding period. They were negative for thyroid antibodies, and there was no previous history of thyroid disease, upper respiratory tract infection, or COVID-19. Laboratory test results and imaging findings were consistent with subacute thyroiditis.

Results
SARS-CoV-2 vaccination can lead to subacute thyroiditis as a phenomenon of ASIA syndrome. Subacute thyroiditis may develop within a few days after the SARS-CoV-2 vaccination. Being in the postpartum period may be a facilitating factor for the development of ASIA syndrome after the SARS-CoV-2 vaccination.

Conclusions
This is the first report of subacute thyroiditis as a phenomenon of ASIA syndrome after inactivated COVID-19 vaccination. Clinicians should be aware that subacute thyroiditis may develop as a manifestation of ASIA syndrome after the inactive SARS-CoV-2 vaccine.
The multifunctional spindle midzone in vertebrate cells at a glance
Authors: Wadsworth Patricia 
Published: May 2021

ABSTRACT
During anaphase, a microtubule-containing structure called the midzone forms between the segregating chromosomes. The midzone is composed of an antiparallel array of microtubules and numerous microtubule-associated proteins that contribute to midzone formation and function. In many cells, the midzone is an important source of signals that specify the location of contractile ring assembly and constriction. The midzone also contributes to the events of anaphase by generating forces that impact chromosome segregation and spindle elongation; some midzone components contribute to both processes. The results of recent experiments have increased our understanding of the importance of the midzone, a microtubule array that has often been overlooked. This Journal of Cell Science at a Glance article will review, and illustrate on the accompanying poster, the organization, formation and dynamics of the midzone, and discuss open questions for future research.
The Cajal body protein coilin is a regulator of the miR-210 hypoxamiR and influences MIR210HG alternative splicing
Authors: Logan Madelyn K. , Lett Katheryn E. , Hebert Michael D. 
Published: May 2021

ABSTRACT
Hypoxia is a severe stressor to cellular homeostasis. At the cellular level, low oxygen triggers the transcription of a variety of genes supporting cell survival and oxygen homeostasis mediated by transcription factors, such as hypoxia-inducible factors (HIFs). Among many determinants dictating cell responses to hypoxia and HIFs are microRNAs (miRNAs). Cajal bodies (CBs), subnuclear structures involved in ribonucleoprotein biogenesis, have been recently proven to contribute to miRNA processing and biogenesis but have not been studied under hypoxia. Here, we show, for the first time, a hypoxia-dependent increase in CB number in WI-38 primary fibroblasts, which normally have very few CBs. Additionally, the CB marker protein coilin is upregulated in hypoxic WI-38 cells. However, the hypoxic coilin upregulation was not seen in transformed cell lines. Furthermore, we found that coilin is needed for the hypoxic induction of a well-known hypoxia-induced miRNA (hypoxamiR), miR-210, as well as for the hypoxia-induced alternative splicing of the miR-210 host gene, MIR210HG. These findings provide a new link in the physiological understanding of coilin, CBs and miRNA dysregulation in hypoxic pathology.
Resilience of cardiac performance in Antarctic notothenioid fishes in a warming climate
Authors: O'Brien Kristin M. , Joyce William , Crockett Elizabeth L. , Axelsson Michael , Egginton Stuart , Farrell Anthony P. 
Published: May 2021

ABSTRACTWarming in the region of the Western Antarctic Peninsula is occurring at an unprecedented rate, which may threaten the survival of Antarctic notothenioid fishes. Herein, we review studies characterizing thermal tolerance and cardiac performance in notothenioids – a group that includes both red-blooded species and the white-blooded, haemoglobinless icefishes – as well as the relevant biochemistry associated with cardiac failure during an acute temperature ramp. Because icefishes do not feed in captivity, making long-term acclimation studies unfeasible, we focus only on the responses of red-blooded notothenioids to warm acclimation. With acute warming, hearts of the white-blooded icefish Chaenocephalus aceratus display persistent arrhythmia at a lower temperature (8°C) compared with those of the red-blooded Notothenia coriiceps (14°C). When compared with the icefish, the enhanced cardiac performance of N. coriiceps during warming is associated with greater aerobic capacity, higher ATP levels, less oxidative damage and enhanced membrane integrity. Cardiac performance can be improved in N. coriiceps with warm acclimation to 5°C for 6–9 weeks, accompanied by an increase in the temperature at which cardiac failure occurs. Also, both cardiac mitochondrial and microsomal membranes are remodelled in response to warm acclimation in N. coriiceps, displaying homeoviscous adaptation. Overall, cardiac performance in N. coriiceps is malleable and resilient to warming, yet thermal tolerance and plasticity vary among different species of notothenioid fishes; disruptions to the Antarctic ecosystem driven by climate warming and other anthropogenic activities endanger the survival of notothenioids, warranting greater protection afforded by an expansion of marine protected areas.
Participation in a Weekly Physical Activity–Related Book Club Improves Health Outcomes over 12 Weeks in Rural Women
Authors: Edwards Elizabeth Skidmore , Sackett Sarah Carson , Sullivan Mariah , Huberty Jennifer 
Published: May 2021

ABSTRACT
Despite the well-documented benefits of physical activity (PA) participation, over half of women do not meet PA guidelines, with greater disparities seen among rural populations. Interventions that include behavioral and cognitive strategies for promoting behavior change are important to improve health outcomes among women. This study aimed to determine whether a book club (i.e., Fit Minded) could improve PA participation, clinical markers of health, and psychosocial measures related to PA and self-perception in adult rural women. Women participated in a 12-wk book club that incorporated reading and discussions related to physical activity and self-worth. PA participation using Fitbits; clinical outcomes (e.g., weight and blood pressure); psychosocial measures related to PA and self-perception, including perceived exercise benefits and barriers, outcome expectations to exercise, PA goal setting, planning, and scheduling; physical self-worth; and global self-worth, were measured at pre- and postintervention (12 wk) in adult rural women. Thirty-two women (age, 48.09 ± 8.96 yr) completed at least 10/12 sessions and all pre- and postintervention measures. Steps per day did not increase from baseline to week 12; however, participants had significant reductions in weight (P = 0.022), body mass index (P = 0.022), and systolic blood pressure (P = 0.047). Participants had significant improvements in several psychosocial measures related to PA participation and self-worth (perceived exercise benefits and barriers, PA goal setting, PA planning and scheduling, all subscales of physical self-worth, and global self-worth; P values < 0.001–0.032), but not outcome expectations related to exercise. Results demonstrate that Fit Minded, with no face-to-face PA component, can improve psychosocial factors related to PA participation and physical self-worth, along with modest improvements in clinical markers of health in rural women. Although objectively assessed PA did not increase, there is evidence of improved health behaviors, which may translate to greater effects over time.
Adaptation and validation of simple tools to screen and monitor for oral PrEP adherence
Authors: Zissette Seth , Tolley Elizabeth E. , Martinez Andres , Hanif Homaira , Gill Katherine , Mugo Nelly , Myers Laura , Casmir Ednar , Duyver Menna , Ngure Kenneth , Doncel Gustavo F. 
Published: May 2021

Introduction
Oral, vaginal and other pre-exposure prophylaxis (PrEP) products for HIV prevention are in various stages of development. Low adherence poses a serious challenge to successful evaluation in trials. In a previous study, we developed tools to screen for general adherence and specifically monitor intravaginal ring adherence within the context of HIV prevention clinical trials. This study aimed to further validate the screening tool and to adapt and provide initial psychometric validation for an oral pill monitoring tool.

Materials and methods
We administered a cross-sectional survey between June and October 2018 at a trial site located near Cape Town, South Africa, and another in Thika, Kenya, with 193 women who had experience using daily oral pills. We fit confirmatory factor analysis models on the screening tool items to assess our previously-hypothesized subscale structure. We conducted an exploratory factor analysis of oral PrEP monitoring items to determine the underlying subscale structure. We then assessed the construct validity of each tool by comparing subscales against each other within the current sample and against our original sample, from a study conducted in four sites in South Africa, including Cape Town.

Results
The screening tool structure showed moderate evidence of construct validity. As a whole, the tool performed in a similar way to the original sample. The monitoring tool items, which were revised to assess perceptions about and experiences using daily oral PrEP, factored into five subscales that showed moderate to good reliability. Four of the five subscales had a similar structure overall to the vaginal ring monitoring tool from which they were adapted.

Conclusions
Accurate measurement of HIV-prevention product adherence is of critical importance to the assessment of product efficacy and safety in clinical trials, and the support of safe and effective product use in non-trial settings. In this study, we provide further validation for these measures, demonstrating the screening tool’s utility in additional populations and adapting the monitoring tool’s utility for different HIV-prevention products.
Cross-cultural adaptation and psychometric properties of the Italian version of the Body Perception Questionnaire
Authors: Cerritelli Francesco , Galli Matteo , Consorti Giacomo , D’Alessandro Giandomenico , Kolacz Jacek , Porges Stephen W. 
Published: May 2021

Background/Objective
The purpose of this study was to cross-culturally adapt the Body Perception Questionnaire Short Form (BPQ-SF) into Italian and to assess its psychometric properties in a sample of Italian subjects.

Methods
A forward-backward method was used for translation. 493 adults were recruited for psychometric analysis. Structural validity was assessed with confirmatory factor analysis and a hypothesis testing approach. Internal consistency was assessed by Cronbach’s alpha and McDonald’s omega. Measurement invariance analysis was applied with an age-matched American sample.

Results
The single-factor structure fit the awareness subscale (RMSEA = .036, CFI = .983, TLI = .982). Autonomic reactivity (ANSR) was well-described by supra- and sub-diaphragmatic subscales (RMSEA = .041, CFI = .984, TLI = .982). All subscales were positively correlated (r range: .50-.56) and had good internal consistency (McDonald’s Omega range: .86-.92, Cronbach’s alpha range: .88-.91). Measurement invariance analysis for the Awareness model showed significant results (p<0.001) in each step (weak, strong and strict) whereas the ANSR showed significant results (p<0.001) only for the strong and strict steps.

Conclusions
Our results support the Italian version of the BPQ as having consistent psychometric properties in comparison with other languages.
Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia
Authors: Forsblom Erik , Tervahartiala Taina , Ruotsalainen Eeva , Järvinen Asko , Sorsa Timo 
Published: May 2021

Background
Matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinases-1 (TIMP-1) have been shown to predict prognosis in sepsis. However, MMP-8 and TIMP-1 in Staphylococcus aureus bacteremia (SAB) lacks evaluation and their role in the pathogenesis of SAB is unclear.

Methods
MMP-8 and TIMP-1 and MMP-8/TIMP-1 molar ratio were determined at days 3, 5 and 28 from positive blood cultures in patients with methicillin-sensitive SAB and the connection to disease severity and early mortality was determined.

Results
Altogether 395 SAB patients were included. Patients with severe sepsis or infection focus presented higher MMP-8 levels at day 3 and 5 (p<0.01). Higher day 3 and 5 MMP-8 levels were associated to mortality at day 14 and 28 (p<0.01) and day 90 (p<0.05). Day 3 MMP-8 cut-off value of 203 ng/ml predicted death within 14 days with an area under the curve (AUC) of 0.70 (95% CI 0.57–0.82) (p<0.01). Day 5 MMP-8 cut-off value of 239 ng/ml predicted death within 14 days with an AUC of 0.76 (95% CI 0.65–0.87) (p<0.001). The results for MMP-8/TIMP-1 resembled that of MMP-8. TIMP-1 had no prognostic impact. In Cox regression analysis day 3 or 5 MMP-8 or day 3 MMP-8/TIMP-1 had no prognostic impact whereas day 5 MMP-8/TIMP-1 predicted mortality within 14 days (HR, 4.71; CI, 95% 1.67–13.3; p<0.01).

Conclusion
MMP-8 and MMP-8/TIMP-1 ratio were high 3–5 days after MS-SAB diagnosis in patients with an infection focus, severe sepsis or mortality within 14 days suggesting that matrix metalloproteinase activation might play a role in severe SAB.
Diagnostic accuracy of pelvic magnetic resonance imaging for the assessment of bone marrow involvement in diffuse large B-cell lymphoma
Authors: Ke Qing , Liao Cheng-Cheng , Tan Xiao-Hong , Guo Bao-Ping , Cen Hong , Li Le-Qun 
Published: May 2021

Purpose
We investigated the efficacy of pelvic magnetic resonance imaging (MRI) in the diagnosis of bone marrow involvement (BMinv) in diffuse large B-cell lymphoma (DLBCL) patients.

Patients and methods
This was a retrospective study of data from a previous study (NCT02733887). We included 171 patients who underwent bone marrow biopsy (BMB) and bone marrow smear (BMS), pelvic MRI, and whole-body positron emission tomography-computed tomography (PET/CT) from January 2016 to December 2019 at a single center. BMB/BMS and whole-body PET/CT results were used as reference standards against which we calculated the diagnostic value of pelvic MRI for BMinv in DLBCL patients. A chi-square test was used to compare detection rates, and a receiver operating characteristic curve was used to evaluate diagnostic value of pelvic MRI. Propensity-score matching was performed according to clinical information, and Kaplan-Meier curves were constructed to compare progression-free survival (PFS) and overall survival (OS) of patients.

Results
The BMinv detection rate of pelvic MRI (42/171) was higher (P = 0.029) than that of BMB/BMS (25/171), and similar to that of PET/CT (44/171; P = 0.901). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of pelvic MRI were 83.33%, 98.37%, 94.15%, 95.24%, and 93.80%, respectively. Median PFS values were as follows: BMB/BMS-positive, 17.8 months vs. BMB/BMS-negative, 26.9 months (P = 0.092); PET/CT-positive, 24.8 months vs. PET/CT-negative, 33.0 months (P = 0.086); pelvic MRI-positive, 24.9 months vs. pelvic MRI-negative, 33.1 months (P<0.001). Median OS values were as follows: BMB/BMS-positive, 22.3 months vs. BMB/BMS-negative, 29.8 months (P = 0.240); PET/CT-positive, 27.9 months vs. PET/CT-negative, 33.9 months (P = 0.365); pelvic MRI-positive, 27.3 months vs. pelvic MRI-negative, 35.8 months (P = 0.062).

Conclusion
Pelvic MRI is effective for detecting BMinv in DLBCL patients, providing a more accurate indication of PFS than BMB/BMS and PET/CT do. It may ultimately be used to improve the accuracy of clinical staging, guide patient treatment, and evaluate prognosis.
Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study
Authors: Yen Hsu-Heng , Su Pei-Yuan , Huang Siou-Ping , Wu Lisha , Hsu Tsui-Chun , Zeng Ya-Huei , Chen Yang-Yuan 
Published: May 2021

Background/purpose
An increased prevalence of non-alcoholic fatty liver disease (NAFLD) is observed in patients with inflammatory bowel disease (IBD) in Western countries. Both intestinal inflammation and metabolic factors contribute to the pathogenesis of IBD-associated NAFLD. The burden of NAFLD is not clear in the Asian population. This study aimed to evaluate the prevalence of NAFLD and liver fibrosis in a cohort of Taiwanese patients with IBD.

Methods
From January to December 2019, patients with IBD who underwent ultrasound examination were enrolled. Hepatic steatosis and fibrosis were measured with liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) using FibroScan. Patients with a history of excessive alcohol or recent steroid use were excluded. Univariate and multivariate analysis were performed.

Results
A total of 81 consecutive patients were enrolled and included in the analysis (45 with ulcerative colitis, 36 with Crohn’s disease). The median age was 42 years old. The patients were classified in terms of body mass index as normal weight (54.3%), underweight (11.1%), overweight (28.4%), and obese (6.2%). The mean CAP increased to 162.22 dB/m in the underweight group, 210.86 dB/m in the normal weight group, 260.7 dB/m in the overweight group, and 274.0 dB/m in the obese group. NAFLD was observed in 29.6% of the patients, 1.2% of which had significant fibrosis. Increased body mass index (odds ratio [OR] 1.33, 95% confidence interval [CI] 1.1–1.62) and older age at IBD diagnosis (OR: 1.05, 95% CI 1–1.11) was found to be associated with the presence of NAFLD.

Conclusion
In this study, the prevalence of NAFLD was lower (29.6%) in IBD patients than in the Western population. Higher BMI and older age were associated with NAFLD in our study.
Double-blinded randomized controlled trial to reveal the effects of Brazilian propolis intake on rheumatoid arthritis disease activity index; BeeDAI
Authors: Matsumoto Yoshinari , Takahashi Kanae , Sugioka Yuko , Inui Kentaro , Okano Tadashi , Mandai Koji , Yamada Yutaro , Shintani Ayumi , Koike Tatsuya 
Published: May 2021

Background and aims
Brazilian propolis reportedly contributed to suppressing disease activity in a mouse model of rheumatoid arthritis (RA), suggesting new treatment options using Brazilian propolis. However, only results from animal experiments have been available, and the suppressive effects of Brazilian propolis on disease activity in humans with RA remain unknown. The purpose of this study was to clinically validate how Brazilian propolis intake changes disease activity in RA patients.

Methods
This study was conducted as a multicenter, double-blinded, randomized, placebo-controlled, parallel-group study of 80 women with RA (median age, 61.5 years; interquartile range, 56.0 to 67.3 years) showing moderate disease activity on Disease Activity Score in 28 joints using erythrocyte sedimentation rate (DAS28-ESR). Test tablets containing Brazilian propolis were used in Group P (40 patients), and Brazilian propolis-free placebo tablets were used as control in Group C (40 patients). Group P received 5 tablets of propolis (508.5 mg of propolis) daily, and Group C received 5 tablets of placebo daily. The intervention lasted 24 weeks, with change in DAS28-ESR set as the primary endpoint. As secondary endpoints, other disease activity assessment (DAS28 using C-reactive protein, simplified disease activity index, clinical disease activity index), ultrasonographic evaluation of synovitis, activities of daily living, quality of life, changes in cytokine levels, and adverse events over the course of the study were also assessed. Data were statistically analyzed by analysis of covariance.

Results
No significant differences in the primary endpoint were identified between groups (Group P vs Group C, effect: 0.14, 95% confidence interval: -0.21 to 0.49, p = 0.427). Likewise, no significant differences were seen between groups for any secondary endpoints. The adverse event rate during the study period was 28% in Group P and 33% in Group C.

Conclusions
Brazilian propolis exerted no effects on disease activity in patients with RA.
Оценка общественного мнения о соблюдении антиотмывочного законодательства в России
Authors: Танющева Наталия Юрьевна , Куницына Наталья Николаевна 
Published: May 2021

Соблюдение законодательства в целом и Федерального закона «О противодействии легализации (отмыванию) доходов, полученных преступным путем, и финансированию терроризма» (ПОД/ФТ) в частности — гражданская обязанность населения и должностных лиц. Вместе с тем информация о его нарушениях довольно часто транслируется в средствах массовой информации и на интернет-ресурсах. В этой связи авторы преследовали цель изучить ценностные установки специалистов по отношению к закону о ПОД/ФТ, а также оценить эффективность надзорно-контрольной деятельности по его соблюдению путем социологического опроса. Состав участников сформирован методом многоступенчатой выборки. Результаты анкетирования обработаны с помощью адаптированной методики Table of Eleven (T11), основанной на концепции рационального выбора, теории обоснованных действий и нормативной теории права.
Исследование факторов, влияющих на соблюдение антиотмывочного закона, осуществлено посредством обобщения и анализа мнений специальных должностных лиц (СДЛ) коммерческих банков, специалистов в области ПОД/ФТ Центрального банка РФ, сотрудников подразделений по борьбе с экономической и организованной преступностью правоохранительных органов. Результаты исследования свидетельствуют, что государственная антиотмывочная политика находит отклик у СДЛ, сам закон понятен исполнителям, однако организация контроля над банками, реализация санкций по отношению к нарушителям и безучастность населения и бизнес-сообщества в информационном взаимодействии с контролирующими органами не способствуют полноценному соблюдению положений антиотмывочного законодательства. Существенному улучшению среды реализации закона призваны способствовать меры по развитию общей солидарности в обществе и расширению программ финансовой грамотности среди предпринимателей.
Благодарность. Исследование выполнено при финансовой поддержке РФФИ в рамках научного проекта № 20-010-00243.