bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons
Authors: Vyleta Nicholas P. , Snyder Jason S 
Published: March 2021

ABSTRACTCritical period plasticity at adult-born neuron synapses is widely believed to contribute to the learning and memory functions of the hippocampus. Experience regulates circuit integration and for a transient interval, until cells are ~6 weeks old, new neurons display enhanced long-term potentiation (LTP) at afferent and efferent synapses. Since neurogenesis declines substantially with age, this raises questions about the extent of lasting plasticity offered by adult-born neurons. Notably, however, the hippocampus receives sensory information from two major cortical pathways. Broadly speaking, the medial entorhinal cortex conveys spatial information to the hippocampus via the medial perforant path (MPP), and the lateral entorhinal cortex, via the lateral perforant path (LPP), codes for the cues and items that make experiences unique. While enhanced critical period plasticity at MPP synapses is relatively well characterized, no studies have examined long-term plasticity at LPP synapses onto adult-born neurons, even though the lateral entorhinal cortex is uniquely vulnerable to aging and Alzheimer’s pathology. We therefore investigated LTP at LPP inputs both within (4-6 weeks) and beyond (8+weeks) the traditional critical period. At immature stages, adult-born neurons did not undergo significant LTP at LPP synapses, and often displayed long-term depression after theta burst stimulation. However, over the course of 3-4 months, adult-born neurons displayed increasingly greater amounts of LTP. Analyses of short-term plasticity point towards a presynaptic mechanism, where transmitter release probability declines as cells mature, providing a greater dynamic range for strengthening synapses. Collectively, our findings identify a novel form of new neuron plasticity that develops over an extended interval, and may therefore be relevant for maintaining cognitive function in aging.
Arpin regulates migration persistence by interacting with both tankyrases and the Arp2/3 complex
Authors: Simanov Gleb , Dang Irene , Fokin Artem I. , Oguievetskaia Ksenia , Campanacci Valérie , Cherfils Jacqueline , Gautreau Alexis M. 
Published: March 2021

AbstractDuring cell migration, protrusion of the leading edge is driven by the polymerization of Arp2/3-dependent branched actin networks. Migration persistence is negatively regulated by the Arp2/3 inhibitory protein Arpin. To better understand Arpin regulation in the cell, we looked for interacting partners and identified both Tankyrase 1 and 2 (TNKS) using a yeast two hybrid screen and co-immunoprecipitation with full-length Arpin as a bait. Arpin interacts with ankyrin repeats of TNKS through a C-terminal binding site on its acidic tail overlapping with the Arp2/3 binding site. To uncouple the interactions of Arpin with TNKS and Arp2/3, we introduced point mutations in the Arpin tail and attempted to rescue the increased persistence of the Arpin knock-out using random plasmid integration or compensating knock-in at theARPINlocus. Arpin mutations impairing either Arp2/3- or TNKS-interaction were insufficient to fully abolish Arpin activity. Only the mutation that affects both interactions rendered Arpin completely inactive, suggesting the existence of two independent pathways, by which Arpin controls migration persistence. Arpin was found to dissolve liquid-liquid phase separation of TNKS upon overexpression. Together these data suggest that TNKS might be mediating the function of Arpin rather than regulating Arpin.
Factors-driven comparison between BIM-based and traditional 2D quantity takeoff in construction cost estimation
Authors: Wahab Abdul , Wang Jun 
Published: March 2021

PurposeQuantity Takeoff (QTO) is an integral part of the decision-making process. Currently, QTO is mostly done using manual or 2D method, and practitioners are considering the use of BIM quantity takeoff as an effective alternative to the traditional 2D software takeoff. However, the existing literature does not have adequate studies to confirm that the use of BIM-based QTO is better than the 2D method. Therefore, this paper aims to expand and improve the existing literature into a more detailed analysis of each element to investigate that BIM is indeed a better option of the two QTO methods.Design/methodology/approachA total of 19 factors in four broad categories, i.e. timely decision making, accuracy, collaboration, and level of details were identified to draw a significant comparison between the two procedures, i.e. BIM-based quantity takeoff and traditional 2D takeoff. Surveys and case study are used to collect data for analysis to achieve the research goals.FindingsThe questionnaire survey showed that using BIM for the QTO process has significant benefits in achieving higher productivity on takeoff, accuracy, clarity and collaboration among the team members. The case study results also showed improvement in BIM-based QTO by achieving higher accuracy and productivity.Originality/valueUnderstanding the difference between the two QTO processes is a challenging task; therefore, this paper contributes to drawing a comparison line between the two processes by introducing the factors that affect the QTO process.
Antecedents of small business financial performance: the role of human resource management practices and strategy
Authors: Chinyamurindi Willie , Kyogabiirwe Janatti Bagorogoza , Kabagabe Jolly Byarugaba , Mafabi Samuel , Dywili MTutuzeli 
Published: March 2021

PurposeThere is noted emphasis on the role of small businesses as conduits for economic development especially in emerging economies. Given this, there is need for constantly seeking for ways to assist small businesses achieve success. Calls exist in the literature to investigate the combined role that strategy and human resource management practices can play leading to efforts of financial success.Design/methodology/approachA structured questionnaire was utilised and data collected from 401 small businesses operating in the Eastern Province of South Africa. Pearson product–moment correlation and hierarchical regression were used in the data analysis.FindingsThe results confirm that a direct relationship exists between strategy and financial performance. Further, the relationship is made significant only through the mediation effect of human resource management practices.Practical implicationsTo fully realise the enactment of strategy within small businesses there is need to pay attention to the role that human resource management practices may potentially have on financial performance. Small business owner-managers need to ground their strategies with sound human resource management practices. Through this, firm financial performance can be attained.Originality/valueThe paper sheds light and presents a model that illustrates the mediating role of human resource management practices on the relationship between strategy and financial performance.
Health literacy and mental health of school principals. Results from a German cross-sectional survey
Authors: Dadaczynski Kevin , Kotarski Claudia , Rathmann Katharina , Okan Orkan 
Published: March 2021

PurposeSchool principals are generally seen as key facilitators for the delivery and long-term implementation of activities on school health promotion, including health literacy. However, there is little evidence on the health literacy and health status of this occupational group. The purpose of this paper is to investigate the health literacy of school principals and its association with mental health indicators.Design/methodology/approachA cross-sectional online survey with German school principals and members of the management board (vice principals) was conducted (n = 680, 68.3% female). Demographic (gender, age) and work characteristics (type of school, professional role) as well as health literacy served as independent variables. Mental health as a dependent variable included well-being, emotional exhaustion and psychosomatic complaints. Next to uni- and bivariate analysis, a series of binary logistic regression models was performed.FindingsOf the respondents, 29.2% showed a limited health literacy with significant differences to the disadvantage of male principals. With regard to mental health, respondents aged over 60 years and those from schools for children with special educational needs were less often affected by low well-being as well as frequent emotional exhaustion and psychosomatic complaints. Taking into account demographic and work characteristics, regression models revealed significant associations between a low level of health literacy and poor mental health across all indicators.Research limitations/implicationsThe cross-sectional nature of this study does not allow to draw conclusions about the causal pathways between health literacy and mental health. Although the sample has been weighted, the results cannot be generalized to the whole population of school principals. There is a need for evidence-based interventions aiming at promoting health literacy and mental health tailored to the needs of school principals.Originality/valueThis is the first study to investigate health literacy and its association with health indicators among school principals.
The role of perceived value of entrepreneurial identity in growth motivation
Authors: Prasastyoga Bramesada , Harinck Fieke , van Leeuwen Esther 
Published: March 2021

PurposeThree studies aimed to investigate the role of perceived value of entrepreneurial identity (i.e. one's evaluation of the worthiness of one's entrepreneurial role) in the relationship between motives for entrepreneurship and business growth motivation among small-business owners.Design/methodology/approachTwo studies were conducted online (Studies 1 and 2) and one study in the field in Indonesia (Study 3); both employed a cross-sectional design with a mixed correlational and experimental approach.FindingsOpportunity-based entrepreneurship, but not necessity-based entrepreneurship, was positively associated with perceived value of entrepreneurial identity. Perceived value of entrepreneurial identity was a positive predictor of future time perspective and growth-pursuit intentions. Study 2 further showed the potential of increasing the salience of both personal and others' positive views of one's business for increasing one's perceived value of their entrepreneurial identity.Research limitations/implicationsThe investigation of perceived value of entrepreneurial identity in this paper extends current knowledge regarding the mechanism through which motives for entrepreneurship predict business growth motivation.Practical implicationsThe paper provides practitioners and policy-makers with useful insights into the importance of small-business owners' perceived value of entrepreneurial identity for business growth motivation, and offers suggestions on how to increase it.Originality/valueThe paper sheds light on the important role of perceived value of entrepreneurial identity in explaining the association between motives for entrepreneurship and business growth motivation.
Estimating the economic return to education in Ghana: a gender-based perspective
Authors: Asravor Richard Kofi 
Published: March 2021

PurposeThe increasing rate at which individuals, especially, females in Ghana are seeking higher education calls for an estimation of the returns to schooling and education in Ghana.Design/methodology/approachThe study employs the Mincer equation to a representative cross-sectional micro-data from Ghana using OLS and instrumental variable (IV) methodologies. The paper uses spouse's education as instruments in the IV estimation.FindingsReturn to schooling was found to be higher for females than males, likewise, membership of an old student associations and location of the household. Returns to education increases as the level of education rises whilst the rate of returns initially increases but fall as labour market experience rises. The study also found that the rates of return to education were higher for Christian, followed by Muslim and believers of other lesser-known religion in Ghana.Research limitations/implicationsReturn to schooling was found to be higher for females than males. Likewise, individuals who are members of an old student association and are in urban areas were found to have a higher return to schooling than individuals who are not members of an old student association and are in rural areas. Returns to education increases as the level of education rises whilst the rate of returns initially increases but fall as labour market experience rises. The study also found that the rates of return to education were higher for Christian, followed by Muslim and believers of other lesser-known religion in Ghana.Practical implicationsWage determination process is different for males and females, across religion and residency. The higher returns to schooling for females imply education is a good investment for women and girls and should be a development priority.Social implicationsThe higher returns to schooling for females imply an investment in girl's education should be a development priority.Originality/valueThe paper extends the existing literature by focussing on the role of religion, old student's association (alma mater) and gender on the differential earning returns to schooling.
Intra-household distribution of resources and income poverty and inequality in Visegrád countries
Authors: Fialová Kamila , Mysíková Martina 
Published: March 2021

PurposeThe authors aim to demonstrate the impact of allowing for unequal intra-household distribution of resources on income poverty and income inequality.Design/methodology/approachThe paper applies a collective consumption model to study the intra-household distribution of resources in Visegrád countries (V4). It utilises subjective financial satisfaction as a proxy for indirect utility from individual consumption to estimate the indifference scales within couples instead of the traditional equivalence scale. The European Union Statistics on Income and Living Conditions (EU-SILC) 2013 and 2018 data are applied.FindingsThis study’s results indicate substantial economies of scale from living in a couple that are generally higher than implied by the commonly applied equivalence scale. The sharing rule estimates suggest that at the mean of distribution factors, women receive a consumption share between 0.4 and 0.6; however, some of the results are close to an equal sharing of 0.5. The female consumption share rises with her contribution to household income. Regarding income poverty and inequality, the authors show that both these measures might be underestimated in the traditional approach to equal sharing of resources.Originality/valueThe authors add to the empirics by estimating indifference scales for Czechia (CZ), Hungary (HU), Poland (PL) and Slovakia (SK), countries that have not been involved in previous research.
Behavioral study of social media followers of a music event: a case study of a Chinese music festival
Authors: Chen Yunxi , Lei Weng Si (Clara) 
Published: March 2021

PurposeWith the increasing importance of social media in promoting events, understanding the relationship between event followers' motivations and their behaviors on an event's social media platform becomes a key success factor to attract event-goers. Previous studies on exploring the relationship between social media and event attendees have concentrated mostly on a Western context social media, for example, Facebook, and Western festivals; studies concerning the East or China are scant. This study uses the Strawberry Music Festival in China as a case study and researches its two official social media platforms: WeChat and Weibo.Design/methodology/approachThe research explores the hedonic and utilitarian motivation of social media followers and investigates followers' browsing and participation behaviors as well as the influence of their usage behaviors on intentions to attend an event. A total of 190 valid responses were collected through an online questionnaire from social media followers of the music festival.FindingsThe findings reveal that both utilitarian and hedonic motivation have significant effects on browsing and participation behaviors. More importantly, browsing and participation behaviors also affect the intentions to attend an event and the electronic word-of-mouth (eWOM) effect.Practical implicationsThe research results provide practical insights for event organizers regarding potential event-goers' usage patterns on social media platforms and their intention to visit events.Originality/valueThis study contributes to the authors’ understanding of the relationship between event attendance and social media behavior, in particular of the East.
Rare plant species are at a disadvantage when both herbivory and pollination interactions are considered in an alpine meadow
Authors: Xi Xinqiang , Zhou Wenlong , Li Zhao , Hu Lei , Dong Yuran , Niklas Karl J. , Sun Shucun 
Published: March 2021

Abstract

Rare plant species often suffer less damage than common species because of positive density‐dependent herbivory, and it has been suggested that this ‘rare species advantage’ fosters plant species coexistence. However, it is unknown whether rare species have an advantage when pollination interactions are also considered.

We hypothesized that a ‘positive density‐dependent pollination success’ across plant species would result in common plants experiencing higher seed set rates compared to rare species, and that positive density‐dependent effects would negate or even override the positive density‐dependent damage due to herbivory resulting in higher seed loss rates in common plant species.

We tested this hypothesis by concurrently examining a plant–predispersal seed predator system and a plant–pollinator system for 24 Asteraceae species growing in an alpine meadow community (Sichuan Province, China). Having previously reported a positive density‐dependent effect on seed loss rates due to seed predators, we here focus on the density‐dependent effects on pollination success by investigating pollinator species richness, visitation frequencies and seed set rates for each plant species. We also estimated the seed output rate of each plant species as the product of seed set rate and the rate of surviving seeds (i.e. 1 − the seed loss rate).

Consistent with our hypothesis, a positive density‐dependent effect was observed for pollinator species richness, visitation frequencies and seed set rates across plant species. Moreover, the positive effect overrode the negative density‐dependent effect of herbivores on seed production, such that common species tended to have a higher seed output rate than rare species (i.e. we observed a ‘rare species disadvantage’).

These results indicate that the low seed output rate of rare species might result from a pollination limitation, and that both mutualistic and antagonistic interactions should be examined simultaneously to fully understand plant species coexistence in local communities.
Chronic pain in parturients with an accidental dural puncture: A case‐controlled prospective observational study
Authors: Binyamin Yair , Heesen Philip , Orbach‐Zinger Sharon , Gozal Yaacov , Halimi David , Frenkel Amit , Ioscovich Alexander 
Published: March 2021

AbstractBackgroundWe set out to examine incidence of chronic headache and back pain in women with PDPH after accidental dural puncture during labor.MethodsChronic headache, backache, and disability were assessed 18‐24 months postpartum. Women with PDPH treated with epidural blood patch (PDPH‐EBP) were identified and matched with women who had a PDPH without epidural blood patch (PDPH‐no EBP), with women with uncomplicated epidural analgesia and with women without epidural analgesia. Our primary outcome was incidence of chronic headache and backache. Secondary outcome was the effect of epidural blood patch on chronic pain development. We used Chi‐square or Fisher's exact test to calculate odds ratios.ResultsThere was no statistically significant difference in demographic characteristics between groups. In the no epidural group, no women reported chronic headache and 2/116 (1.7%) reported chronic backache. In the uncomplicated epidural group, no women reported chronic headache and 7/116 (6.0%) reported chronic backache. In the PDPH‐no EBP group, 9/56 (16.1%) women reported chronic headache and 10/56 (17.9%) reported chronic backache. In the PDPH‐EBP group, 12/59 (20.3%) had chronic headache and 14/59 (23.7%) had chronic backache. No women in the no epidural or uncomplicated epidural group reported disability (chronic pain score of 3 or 4). High disability was reported by 8.9% of women in the PDPH‐no EBP group and by 8.4% in the PDPH‐EBP group.ConclusionWomen with PDPH had a high incidence of chronic headache, back pain, and disability. We did not find a statistically significant difference in chronic pain development between conservatively treated and EBP‐treated patients.
Stand boundary effects on obligate seeding Eucalyptus delegatensis regeneration and fuel dynamics following high and low severity fire: Implications for species resilience to recurrent fire
Authors: Gale Matthew G. , Cary Geoffrey J. 
Published: March 2021

AbstractIncreased fire frequency can result in a decline of obligate seeding plants, which rely on re‐seeding for population persistence following canopy scorching fire. The resilience of obligate seeding plants to fire at any point in time depends on plant maturity and the size of plants in relation to potential fire scorch height. We investigated variation in the resilience of post‐fire regenerating Eucalyptus delegatensis subsp. delegatensis (alpine ash) to a short inter‐fire interval at its boundaries with E. fastigata (brown barrel) stands. The resilience of post‐fire E. delegatensis regeneration was modelled across these stand boundaries as a function of the height of the plants, their reproductive maturity and predicted fire behaviour derived from local fuel characteristics. We measured these attributes 14 years following the Canberra 2003 wildfires and stratified study sites by fire severity. The height and reproductive maturity of post‐fire E. delegatensis saplings decreased at stand boundaries with E. fastigata, while fuel was uniformly abundant and capable of supporting canopy scorching fire under mild fire weather conditions. This suggests that E. delegatensis is less resilient to frequent fire in the presence of interspecific competition and other environmental conditions that occur at stand boundaries, which represent the edge of the species’ realised niche. With forecasts for increased fire frequency in south eastern Australia, persistence of E. delegatensis may be greatest in pure stands corresponding to the core of the species’ realised niche, and in moist and sheltered topographic areas that are less prone to frequent canopy scorching fire. Our findings suggest the importance of considering fine‐scale spatial variation in important obligate seeding plant traits when predicting and managing the response of obligate seeding species to frequent fire.