bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Gastro-retentive Dosage Form of a New Promising Anti-tuberculosis Drug Macozinone
Authors: Nesterenko V. G. , Bolgarin R. N. , Rudoy B. A. , Salakhetdinov D. K. , Kazaishvili Yu. G. , Scherbakova V. S. , Nikitina N. A. , Medvedev Yu. V. , Fisher E. N. , Malashenko E. A. , Shohin I. E. 
Published: August 2021

Introduction. Due to increase in the frequency of detecting cases of tuberculosis caused by strains of mycobacteria with resistance not only to traditional, but also recently introduced into clinical circulation anti-tuberculosis drugs, it is urgent to search for and develop new drugs that can be effective against multidrug-resistant (MDR-TB) and extensively drug resistant (XDR-TB) strains. One of the most promising classes of such compounds are fluorine derivatives of benzothiazinones, and particularly compound PBTZ169 (INN macozinone). This antibiotic has a high specificity against mycobacteria tuberculosis (M. tuberculosis), inhibiting one of the key enzymes of cell wall synthesis. However, macozinone as an active pharmaceutical ingredient has significant features of physical and chemical properties that hinder the development of oral dosage forms based on it. It is classified as class IV by BCS and is characterized by a very low solubility and lipophilicity, a pronounced dependence of dissolution rate on the pH of the medium, and very low bioavailability when taken orally.Aim. To substantiate the target profile, critical quality attributes and to develop a prototype of an oral dosage form with modified release of macozinone, allowing to maximize its pharmacological activity.Materials and methods. Using pharmaceutical substance macozinone hydrochloride and various excipients, experimental tablets with a dosage of 500 mg macozinone were developed. The influence of the composition of the media and the added excipients on the solubility of macozinone in various biorelevant media, the degree of swelling in the liquid and the degree of mucoadhesion of the experimental tablets to the mucus of the pig stomach were evaluated. The HPLC method was used to evaluate the kinetics of the release of the active substance.Results and discussion. In this work, the expediency of creating macozinone-containing gastro-retentive dosage forms with a slow release of the active substance, the delay mechanism of which is provided by swelling and increased adhesion to the gastric mucosa, has been substantiated. Various tablet samples were experimentally tested in which the modification of the release of the active substance and the degree of swelling and mucoadhesion were varied by introducing various excipients into the formulations, including known swelling and bioadhesive matrix agents.Conclusion. According to the results of the experiments, samples of high-dose (500 mg) swellable and mucoadhesive tablets created by the technology of two-stage granulation with the inclusion of macozinone - hydroxypropyl-beta-cyclodextrin mixtures in the primary granules and introduction of combinations of soluble and insoluble hydrophilic matrix agents into the intergranular space were recognized as the most promising for subsequent pharmacokinetic studies.
Modeling the Formation of Liposomes with Vinpocetine from Soy Lecithin Phospholipids by Molecular Dynamics
Authors: Polkovnikova Yu. A. 
Published: August 2021

Introduction. Liposomal preparations have the following advantages: they protect body cells from the toxic effects of drugs; prolong the action of the drug introduced into the body; protect medicinal substances from degradation; promote the manifestation of targeted specificity due to selective penetration from blood into tissues; change the pharmacokinetics of drugs, increasing their pharmacological effectiveness; allow you to create a water-soluble form of a number of medicinal substances, thereby increasing their bioavailability. The development of liposomal forms of vinpocetine is highly relevant. Currently, when developing the composition of liposomal forms, molecular modeling methods are widely used, which are a convenient method for predicting both the properties of the membranes themselves and aspects of the interaction of membranes with small molecules or proteins.Aim. The aim of this study is to model the process of liposome assembly from soy lecithin phospholipids in the presence of vinpocetine by the molecular dynamics method; as well as predicting the distribution of vinpocetine between the internal cavity of the liposome, the phospholipid membrane, and the dispersion medium based on the simulation results.Materials and methods. To simulate the process of liposome formation, the method of coarse-grained molecular dynamics in a Martini 2.2 force field was used using the Gromacs 2016.4 program. The assembly of the simulated system - a solution of soy lecithin phospholipids in water was performed using the Internet service Charmm-GUI-> Inputgenerator-> Martinimaker-> Randombuilder.Results and discussion. The results of molecular modeling showed that the vinpocetine molecules did not penetrate into the liposome, but were adsorbed on its surface. This is due to the low solubility of vipocetin in the hydrophobic medium of the soy lecithin liposome membrane.Conclusion. It was shown that the minimum diameter of a liposome formed from purified soy lecithin is 15.3 nm. Vinpocetine does not penetrate into liposomes from purified soy lecithin, but is adsorbed on the outer surface of their membrane. The surface excess in this case, according to the results of modeling coarse-grained molecular dynamics at a temperature of 298 K in an alcohol-water medium, is 1.2 • 10-7 mol/m2.
Akar Mimosa Pudica L yang Diozonasi Terhadap Penyembuhan Luka Ulkus Diabetikum
Authors: Ermawati Eli , Sari Anita Aprilia Yunita , Anggraini Musdhalifah Hesti , Pringgani Vida Dwi , Kusumaningrum Niken Safitri Dyah 
Published: August 2021

Diabetes mellitus adalahpenyakit tidak menular termasuk salah satu penyebab kejadian mortalitas di dunia, termasuk di Indonesia. Prevalensi diabetes di Indonesia berdasarkan data semakin meningkat dalam setiap tahunnya. Salah satu komplikasi yang paling mengancam adalah ulkus diabetikum. Selama beberapa dekade terakhir, perkembangan teknologi plasma medis menggunakan ozon sebagai agen yang membantu penyembuhan luka. Aplikasi dan riset Mimosa pudica L.sebagai wound healing. Tujuan dari review narrative ini untuk mengetahui potensi ekstrak Mimosa pudica L dengan ozonasi sebagai terapi topikal untuk meningkat penyembuhan ulkus diabetikum. Pencarian literatur menggunakan database Science direct, PubMed, Ebsco, Scopus dan ProQuest dengan kriteria inklusi yang ditentukan. Hasil dari studi literatur bahwa kandungan senyawa kimia pada ekstrak akar Mimosa pudica L. telah terbukti memiliki aktivitas penyembuhan luka dan aktivitas antidiabetik. Pemanfaatan ozonasi sebagai agen antibakteri dengan menggunakan alat degenerator ozon untuk mengubah gas ozon menjadi cair ke dalam suatu ekstrak menggunakan parameter tertentu dapat mendukung wound healing. Sehingga perpaduan ekstrak akar Mimosa pudica L. dengan proses ozonasi memiliki potensi untuk dikembangkan dalam menunjang penyembuhan ulkus diabetikum agar lebih efektif dan efisien.
Pengaruh Terapi Musik Flute Terhadap Penurunan Gula Darah Pada Pasien Diabetes Melitus Tipe II
Authors: Suryati Ida , Primal Def , Sulni Rahayu Putri 
Published: August 2021

Diabetes mellitus tipe II adalah kondisi hiperglikemia puasa yang terjadi meskipun insulin endogen tersedia. Adanya peningkatan kejadian angka dari tahun ke tahun sehingga membutuhkan intervensi untuk menurunkan kadar glukosa darah. Minimnya pengetahuan perawat puskesmas tentang cara lain dalam menurunkan gula darah seperti melakukan terapi musik Flute yang memberikan efek relaksasi pada penderita diabetes melitus sehingga dapat menghambat produksi hormon kortisol dan menurunkan kadar gula darah.. Adapun tujuan penelitian ini untuk menganalisis pengaruh terapi musik Flute terhadap penurunan gula darah pada pasien diabetes mellitus Tipe II dengan metode penelitian quasy eksperimental design, dengan pendekatan one group pretest-posttest design dengan sampel sebanyak 24 orang dengan teknik purposive sampling, data diolah menggunakan uji-t berpasangan. Adanya penurunan rata- rata kadar gula darah sebelum dibandingkan dengan sesudah dilakukan terapi musik flute. Hasil penelitian menunjukkan ada pengaruh terapi musik suling terhadap penurunan gula darah dengan selisih rata-rata sebelum dan sesudah dilakukan adalah 51,25 dengan p-value 0,000 (<0,05). Sehingga dapat disimpulkan bahwa ada pengaruh terapi musik flute terhadap penurunan gula darah pada pasien diabetes mellitus tipe II.
Keberhasilan Ibu Penyintas Covid dalam Kegiatan Menyusui
Authors: Meilinda Vittria 
Published: August 2021

Di saat pandemic Covid-19 yang sedang terjadi di Indonesia, menyusui menjadi perlindungan yang sangat baik untuk bayi. Keberhasilan menyusui sangat penting didapatkan bagi seorang ibu untuk kesehatan dan kelangsungan hidup bayi dimana efek perlindungan ASI sangat kuat dalam melawan infeksi penyakit melalui peningkatan daya tahan tubuh bayi. Hingga saat ini dalam berbagai penelitian bahwa virus ini belum pernah ditemukan di dalam ASI sehingga ini menjadi jalan untuk ibu terus melanjutkan pemberian ASI kepada bayi. Tujuan penelitian ini untuk mengetahui secara mendalam keberhasilan ibu penyitas covid dalam menyusui bayinya. Metode penelitian kualitatif langsung kepada 30 informan, dengan pendekatan studi fenomenologi. Pengumpulan data dilakukan melalui observasi dan in-depth interview. Data dianalisis dengan menggunakan Interpretative Phenomenological disesuaikan dengan ukuran Pelaksanaan Praktek Menyusui di masa Pandemi Covid-19 Kementerian Kesehatan. Hasil penelitian yang dilakukan selama masa pandemi di tahun 2020 menggambarkan hasil yang sangat signifikan dari upaya laktasi pada ibu dalam segi pengalaman menyusui dan masalah laktasi yang dihadapi saat pandemi dimana ibu sangat membutuhkan dukungan pada ibu menyusui . Disimpulkan bahwa upaya dalam keberhasilan ibu menyusui khusus pada masa pandemi terletak dari pengalaman menyusui serta dukungan yang baik untuk ibu terus memberikan ASI.
Hubungan Infeksi Soil Transmitted Helmith dengan Kadar Kolesterol Darah Pada Anak dan Dewasa di Daerah Endemik Kecacingan Sumatera Barat
Authors: Nurhayati Nurhayati , Hasmiwati Hasmiwati , Novita Eka 
Published: August 2021

Soil transmitted Helminth (STH) merupakan penyebab tersering dari infeksi kronis pada usus manusia. Kemampuan cacing memodulasi respon imun host melalui Th2 yang memicu sitokin anti inflamatori diduga mempengaruhi kadar kolesterol darah pada individu yang terinfeksi STH, yang akan memiliki efek protektif terhadap penyakit metabolik. Oleh karena itu penelitian ini bertujuan melihat hubungan infeksi STH dengan kadar kolesterol darah, sebagai dasar helminthic therapy dan evaluasi terhadap program pengobatan massal. Infeksi STH diperiksa dengan pemeriksaan tinja metode langsung dengan iodine, sedangkan untuk mengukur jumlah telur per gram tinja dilakukan dengan metode Kato Katz. Kadar kolesterol total darah diperiksa dengan metode enzimatik CHOD-PAP. Semua subjek penelitian yang terinfeksi STH pada penelitian ini tergolong infeksi ringan. Kadar kolesterol individu yang terinfeksi STH didapatkan lebih rendah dibandingkan kadar kolesterol individu yang tidak terinfeksi STH, baik pada anak ataupun dewasa (p<0,05), sehingga dapat disimpulkan bahwa terdapat hubungan yang bermakna antara infeksi STH dengan kadar kolesterol darah, sekalipun pada infeksi ringan.
Definitions of Severity in Treatment Seeking Studies of Febrile Illness in Children in Low and Middle Income Countries: A Scoping Review
Authors: Brunner Nina C. , Awor Phyllis , Hetzel Manuel W. 
Published: August 2021

Objectives: Understanding treatment seeking for severe febrile illness (SFI) is methodologically challenging. In this scoping review, we investigate definitions of severe febrile illness in treatment seeking studies on children under 5 years of age in low and middle income countries. We analyze the association of SFI definitions with different concepts of treatment seeking and identify related research gaps.Methods: We searched Pubmed, Scopus and WHOLIS, and screened references of included publications for eligibility.Results: Definitions of SFI had either a biomedical perspective (predominantly in quantitative studies) or a caregiver perspective (predominantly in qualitative studies). In quantitative analyses of treatment seeking, severity was more often conceptualized as a determinant rather than an outcome of a treatment seeking process. The majority of quantitative analyses only included surviving children or did not explicitly mention dead children.Conclusion: Different research questions lead to diverse definitions and concepts of severity and treatment seeking outcomes, which limits the comparability of the available evidence. Systematic exclusion of dead children is likely to bias inferences on the association of treatment seeking and health outcomes of children with SFI in low and middle income countries.
THE SURVIVABILITY OF SMALL MICRO ENTERPRISE (SME) IN INDRAGIRI HULU DURING THE EPIDEMIC
Authors: Saputra Marwan Indra , Fransinatra Ziko , Adjie Gerhana 
Published: August 2021

The spread of Corona Virus in along 2020 is unpredictable and uncontrolled. According to this condition, a lot of Big Company weakened and got involved in to a worst situation and even collapse. And of course, Small Micro Enterprise (SME) will be or had been bothered by the impact. Indonesian Government has made various efforts to avoid the effects of the COVID-19 epidemic on SME. There are a lot of ways and approaches implemented to overcome it. The objectives of the study is to find win-win solution for SME to keep survive during the COVID-19 epidemic. The population of the study is the Indragiri Hulu SME Entrepreneurs. The Category of five years are selected to be the sample which is limited to 10 successful survival entrepreneurs that represents the descriptive category. Moreover, the data analysis technique used in this study was data analysis with a data reduction model that was obtained from data collection and data display. The results of this study show six strategies based on push and pull factors theories, as social psychology theory which develop the survivalist entrepreneurship in Indragiri Hulu. The strategy also needs to pay attention on opportunity, added value, necessity, overcome and avoiding dissatisfaction of the previous way. Furthermore, it is also suggested that an entrepreneur of SME players needs to play strategy in order to establish and survive the business during the epidemic, because the epidemic is not the end of everything.
Maladies neurocutanées: bien connues et redécouvertes
Authors: Tölle Sandra 
Published: August 2021

L’association d’anomalies développementales du cerveau, de la peau et des yeux a été résumée en 1932 par l’ophtalmologue néerlandais Jan van der Hoeve sous le terme de phacomatoses. Il y incluait les neurofibromatoses, la sclérose tubéreuse et plus tard la maladie de von Hippel-Lindau. En même temps de l’autre côté de l’Atlantique, Paul Ivan Yakovlev et Riley H. Guthrie proposèrent le terme de maladie neurocutanée, étant arrivés à la conclusion que les malformations de l’ectoderme (peau, cerveau, rétine, œil), comme c’est le cas pour la neurofibromatose, la sclérose tubéreuse ou le syndrome de Sturge-Weber, ont souvent en commun des manifestations cutanées, des troubles cognitifs et une épilepsie. Ils ont aussi constaté que la peau est souvent une ouverture diagnostique vers le système nerveux central, ce qui est toujours le cas.
Pengaruh Leaflet Covid-19 Terhadap Ibu Dan Bayi Pada Masa Pandemi Di Praktik Mandiri Bidan
Authors: Maryani Deni , Himalaya Dara 
Published: August 2021

Early 2020, the Corona virus (Covid-19) was officially designated by the WHO as a dangerous infectious disease that can be transmitted to humans. During the pandemic situation, the group that is vulnerable to contracting Covid-19 is the midwife, whose main task is maternal and child health services at the basic level. Midwives must understand how the protocol for maternal and child health services is to avoid the transmission of Covid-19. The purpose of this study was to analyze the effect of the Covid-19 leaflet protocol on maternal and infant care, the research method used was quasi-experimental, with one group pre and post test. The population in the study was midwives who opened independent practice during the Covid-19 pandemic in Bengkulu City, the sampling technique was random sampling, which returned 35 samples. Data analysis with chi square method. The results of the statistical test showed that the level of knowledge of respondents after being given the Covid-19 protocol leaflet for maternal and infant services, there was an increase in the good category from 71.43% to 94.29%. The category was originally 57.1% to 5.71%, and knowledge was low from 20.0% to 0.0%. There is a difference in the level of knowledge after giving the intervention and before giving the intervention using leaflet media and there is no difference in attitude between before the intervention and the intervention after using the leaflet.

Keywords: Leaflet, Maternal Neonatal,Covid-19

ABSTRAK

Awal tahun 2020 Coronavirus (Covid-19) resmi ditetapkan oleh WHO sebagai penyakit infeksi berbahaya yang dapat menular ke manusia. Saat situasi pandemi kelompok yang rentan untuk tertular Covid-19 adalah bidan, dimana tugas utamanya adalah melayani kesehatan ibu dan anak ditingkat pelayanan dasar. Bidan harus memahami bagaimana protokol pelayanan kesehatan ibu dan anak, agar terhindar dari penularan Covid-19. Tujuan penelitian ini adalah menganalisis pengaruh leaflet protokol Covid-19 terhadap pelayanan ibu dan bayi, metode penelitian yang digunakan adalah quasi experiment, dengan satu grup pre dan post test. Populasi dalam penelitian adalah bidan yang membuka praktik mandiri selama pandemi Covid-19 di Kota Bengkulu, teknik pengambilan sampel dengan random sampling yaitu berjumlah 35 sampel. Analisis data dengan metode chi square. Hasil uji statistik didapatkan tingkat pengetahuan responden setelah diberikan leaflet protokol Covid-19 pelayanan ibu dan bayi, terjadi peningkatan untuk kategori baik dari 71.43% menjadi 94.29%. Kategori sedang yang awalnya 57.1% menjadi 5.71%, dan pengetahuan rendah dari 20.0% menjadi 0.0%. Terdapat perbedaan tingkat pengetahuan bidan setelah pemberian intervensi dan sebelum pemberian intervensi dengan menggunakan media leaflet dan tidak terdapat perbedaan sikap antara sebelum intervensi dan setelah intervensi dengan menggunakan leaflet.
Kata Kunci: Leaflet, Maternal Neonatal, Covid-19
Pengaruh Jus Bayam terhadap Peningkatan Kadar Hemoglobin Ibu Hamil Trimester I dan II
Authors: Zuiatna Dian , Liesmayani Elvi Era , Tan Reni Julia 
Published: August 2021

One of the threats that can harm pregnant women and fetuses is anemia. In Indonesia, in light of the consequences of Riskesdas in 2013, the pervasiveness of weakness in pregnant ladies was 37.1%. The motivation behind this examination was to decide the impact of spinach juice on expanding hemoglobin levels in pregnant ladies in the first and second trimesters at the Niar Pratama center in 2020. The exploration plan in understanding with this investigation was a semi test utilizing the One Group Pretest Posttest approach. The study was conducted in September 2020. The sample in this study was 10 people. Analysis of this statistical test using the t test (Test Paired Sample T Test). The results of this study using statistical tests obtained a p-value of 0.000 <0.05, so that there is an effect between giving spinach juice to increasing hemoglobin levels in pregnant women in the second and second trimesters. In light of the aftereffects of examination on the effect of spinach juice on expanding hemoglobin levels in pregnant ladies in the first and second trimesters at the Niar Pratama Clinic in 2020, explicitly there is an impact between giving spinach juice to increment hemoglobin levels in pregnant ladies.

Keywords: Spinach Juice, Hb, Pregnant Women
ABSTRAK

Salah satu ancaman yang dapat membahayakan ibu hamil dan janin adalah anemia. Di Indonesia, berdasarkan hasil Riskesdas tahun 2013, prevalensi anemia pada ibu hamil sebesar 37,1%. Tujuan penelitian ini adalah untuk mengetahui pengaruh jus bayam terhadap peningkatan kadar hemoglobin pada ibu hamil trimester I dan II di Klinik Pratama Niar tahun 2020. Desain penelitian yang sesuai dengan penelitian ini adalah Quasi Eksperimen dengan menggunakan pendekatan One Group Pretest Posttest. Penelitian dilakukan pada bulan September tahun 2020. Sampel pada penelitian ini yaitu sebanyak 10 orang. Analisa uji statistik ini menggunakan uji t (Uji Paired Sampel T Test). Hasil dari penelitian ini menggunakan uji statistik didapatkan nilai p-value sebesar 0,000 < 0,05, sehingga ada pengaruh antara pemberian jus bayam terhadap peningkatan kadar hemoglobin pada ibu hamil trimester I dan II. Berdasarkan hasil penelitian mengenai dampak jus bayam terhadap peningkatan kadar hemoglobin pada ibu hamil trimester I dan II di Klinik Pratama Niar tahun 2020, secara spesifik terdapat pengaruh antara pemberian jus bayam untuk meningkatkan kadar hemoglobin pada ibu hamil.

Kata Kunci: Jus Bayam, Hb, Ibu Hamil
Terapi Akupreseur Untuk Penurunan Nyeri Haid
Authors: Susanti Neny Yuli 
Published: August 2021

Based on a survey from the WHO showed that 80% of adolescents aged 17-21 years experienced menstrual pain. Menstrual pain or dysmenorrhea is a condition that bothers most women during menstruation regardless of age, with the highest percentage in their early teens experiencing menarche. One of the non-pharmacological treatment of menstrual pain is acupressure therapy. The purpose of this study was to determine the decrease in menstrual pain after giving acupressure therapy. The design of this research is pre-experimental (One group pre-test post-test). The research was carried out for 3 month. The population in this study were all young women at the Salafiyah Syafiiyah Islamic Boarding School in Situbondo and the sample size was 30 young women. The research instruments were in the form of observation sheets and questionnaires with accidental sampling technique. From the results of SPSS data analysis, it was found that the mean was 5.43 for the level of pain before acupressure therapy and the mean was 2.83 for the level of pain after the acupressure therapy. Acupressure is a simple form of therapy to reduce menstrual pain. This study can be used as a reference in developing alternative midwifery care related to reducing menstrual pain in adolescent girls with acupressure techniques.

Keywords: Acupressure Techniques, Menstrual Pain
ABSTRAK

Berdasarkan survey dari WHO memperlihatkan bahwa remaja usia 17-21 tahun 80% mengalami nyeri haid. Nyeri haid atau disminore biasa disebut dengan kondisi yang mengurangi kenyamanan saat beraktivitas dan sebagian besar perempuan saat menstruasi dan tidak melihat usia dengan jumlah mayoritas di saat remaja awal dan baru mengalami menstruasi awal. Salah satu penanganan nyeri haid secara non farmakologis adalah dengan terapi akupreseur . Tujuan penelitian ini adalah mengetahui penurunan nyeri haid setelah pemberian terapi akupreseur. Desain penelitian ini adalah pra experiment (one group pre test post test). Pelaksanaan penelitian dilakukan selama 3 bulan. Populasi dalam penelitian ini adalah seluruh remaja putri di Pondok Pesantren Salafiyah Syafiiyah Situbondo dan besar sampel 30 remaja putri. Intrument penelitian berupa lembar observasi dan kuesioner dengan teknis accidental sampling. Dari hasil analisa data SPSS didapatkan mean 5,43 untuk tingkat nyeri sebelum terapi akupreseur dan mean 2,83 untuk tingkat nyeri sesudah terapi akupreseur. Akupreseur merupakan salah satu bentuk terapi sederhana untuk menurunkan nyeri haid. Penelitian ini dapat digunakan sebagai referensi dalam pengembangan asuhan alternatif kebidanan yang berkaitan dengan penurunan nyeri haid pada remaja putri dengan teknik akupreseur.

Kata kunci : Terapi Akupreseur, Nyeri Haid