bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kościół i państwo w nauczaniu ks. Jerzego Popiełuszki
Authors: Sochoń Jan 
Published: November 2021

Artykuł przedstawia – na tle ważnych wydarzeń z biografii ks. Jerzego Popiełuszki – najważniejsze kwestie poruszane przez niego w cyklu homilii wygłaszanych w kościele św. Stanisława Kostki na warszawskim Żoliborzu podczas trwającego w Polsce stanu wojennego. Spośród treści wówczas przez niego formułowanych istotne miejsce zajmowały zagadnienia relacji Kościoła do państwa komunistycznego. Ksiądz Popiełuszko piętnując najgroźniejsze poczynania oficjalnej władzy był świadom, że w ten sposób naraża się na szykany, a nawet śmierć. Miał jednakowoż nadzieję, że stając w obronie prześladowanych i zamykanych w więzieniach dopełnia niejako „dyplomatyczną” aktywność ówczesnych hierarchów Kościoła i zarazem wypełnia osobistą misję duszpasterską. Msze św. za Ojczyznę i tych, którzy dla niej cierpią uznawał przecież za konieczne narzędzie oddziaływania na świadomość społeczną i próbę zawsze możliwego narodowego pojednania. Z dzisiejszej perspektywy należy te heroiczne poczynania uznać za wyraz nie tylko głębokiego patriotyzmu, ale także za znak religijnie pojętej ofiary.
Eschatologia w teorii i w praktyce. Próba prezentacji zagadnienia na podstawie wybranych tekstów ks. Jana Berthiera MS
Authors: Kulik Bogdan 
Published: November 2021

Artykuł jest próbą prezentacji dwóch tekstów ks. Jana Berthiera MS – założyciela Misjonarzy Świętej Rodziny: traktatu o rzeczach ostatecznych i praktycznej metody towarzyszenia umierającym. Celem artykułu nie jest krytyczna analiza eschatologii Berthiera, lecz wykazanie na jej przykładzie konieczności łączenia akademickiego wykładu eschatologii (teoria) z duszpasterstwem (praktyka). Dokonana prezentacja prowadzi do trzech wniosków: 1) nieustająca konieczność obecności eschatologii w nauczaniu i praktyce Kościoła; 2) potrzeba aktualizowania rozumienia jej treści i sposobu przekazu; 3) waga spójności teorii i praktyki eschatologicznej.
Truth and Error of Conscience According to the Magisterium of the Church
Authors: Spindelböck Josef 
Published: November 2021

The relation of truth and error in conscience according to the newer actual Magisterium of the Church is the theme of this article, following a hermeneutic of reform in continuity (Benedict XVI). Emphasis is given first on Veritatis splendor by Pope John Paul II, then on Humanae vitae by Pope Paul VI and finally, in a special way, to Amoris laetitia by Pope Francis. A focus is laid on the dimension of virtue education since this helps the persons involved not only to grasp the truth of relevant moral values but also to realise morally good acts with the help of Divine grace. Even in situations of personal limitation, there is always a light of God telling the person how to know and do the good.
Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia
Authors: Goodman William G. , Ward Donald T. , Martin Kevin J. , Drayer Debra , Moore Carol , Xu Jiahong , Lai James , Chon Yun , Nemeth Edward. F. 
Published: November 2021

Significance Statement
Hyperphosphatemia may contribute to secondary hyperparathyroidism among patients with CKD, but the mechanism responsible remains uncertain. Recent in vitro studies indicate that high levels of phosphorus attenuate the level of calcium receptor activation, and this observation has led to speculation that hyperphosphatemia diminishes the efficacy of calcimimetic agents when used clinically. Using data from large, prospective clinical trials of the calcimimetic agents etelcalcetide and cinacalcet, the authors demonstrate that hyperphosphatemia modestly reduces the effect of these agents in lowering parathyroid hormone (PTH) levels among those with secondary hyperparathyroidism undergoing hemodialysis. These findings demonstrate a role for phosphate as a negative modulator of calcium receptor activation in vivo in humans, but overall, it does not modify the PTH-lowering effect of either agent in a therapeutically meaningful way.

Background
Phosphorus levels in the range seen clinically among patients undergoing dialysis have been reported to attenuate calcium receptor activation and modify parathyroid hormone (PTH) release from isolated parathyroid glands in vitro. Some clinicians and providers of dialysis thus have suggested that calcimimetic agents are ineffective and should not be used to manage secondary hyperparathyroidism among those undergoing dialysis when serum phosphorus concentrations exceed certain threshold levels.

Methods
To determine whether hyperphosphatemia diminishes the therapeutic response to calcimimetic agents, we used data from large clinical trials to analyze the effects of etelcalcetide and cinacalcet to lower plasma PTH levels in individuals on hemodialysis who had secondary hyperparathyroidism and varying degrees of hyperphosphatemia.

Results
Plasma PTH levels declined progressively during 26 weeks of treatment with either etelcalcetide or cinacalcet without regard to the degree of hyperphosphatemia at baseline. However, with each calcimimetic agent, the decreases in PTH from baseline were less at each interval of follow-up during the trials among participants with serum phosphorus levels above one of three prespecified threshold values compared with those with serum phosphorus levels below these thresholds.

Conclusions
These in vivo findings are the first in humans to support the idea that hyperphosphatemia attenuates calcium receptor activation by calcium ions and by calcimimetic agents. The effect of hyperphosphatemia on the responsiveness to calcimimetic agents appears relatively modest, however, and unlikely to be significant therapeutically. The efficacy of treatment with calcimimetic agents for lowering plasma PTH levels among those with secondary hyperparathyroidism remains robust despite substantial elevations in serum phosphorus.
Students’ Power Relationships within an EFL Classroom
Authors: Gutiérrez Pulido Lila Maribel 
Published: November 2021

This paper reports the results of a research study whose main purpose was to identify aspects related to power relationships in a group of ninth-grade English learners. An EFL classroom was used as the setting to analyze power relationships among students. A qualitative case study was carried out in a public school from Sogamoso; the participants were 8 students, selected at random from a group of 35. The data was gathered through field notes, video recordings and focused interviews. After analyzing the data, it was found that aspects connected to power relationships sometimes either helped or hindered the participants’ English language learning process. Positive and negative features concerning power relationships within the EFL classroom were identified. Positive features include the use of power to motivate the accomplishment of tasks. Negative features include the use of power to suppress others thereby limiting their ability to express opinions in class.
The COVID-19 Pandemic: Role of Coping Humor and Internal Health Locus of Control on Social Dysfunction and Anxiety & Depression
Authors: Sumantri Muhammad Arief , Zahrani Zahrani , Ainiyah Hilda Rosa , Idham Azmul Fuady 
Published: November 2021

The concerns about the impact of social distancing on mental health have been widely discussed. This study aimed to know the predictive effect of coping humor and Internal Health Locus of Control (Internal HLoC) on social dysfunction and anxiety & depression during the implementation of the COVID-19 social distancing agenda. This study was also intended to assess the effect of humor content on coping humor. A quantitative approach was used as the method ofthe study with 243 online-recruited participants, and PLS-SEM analysis was applied to find out the predictive effect in this study. The results and conclusions showed that anxiety & depression predict social dysfunction (β = 0.584, t-value = 11.93, f2 = 0.563). It was found that coping humor was able to directly increase the Internal HLoC (β = 0.187, t-value = 2.60, f2 = 0.036) and indirectly decrease social dysfunction (β = -0.144, t-value = 2.85) and anxiety & depression (β = -0.070, t-value = 2.42). Humor content unrelated to the issue of COVID-19 directly increase the coping-humor level (β = 0.266, t-value = 4.13,f2= 0.076), and indirectly increase Internal HLoC (β = 0.050, t-value = 2.07), and decrease anxiety & depression level (β = -0.046, t-value = 2.20). On the other hand, Internal HLoC directly decrease levels of social dysfunction (β = -0.233, t-value = 4.126, f2 = 0.089) and anxiety & depression (β = -0.373, t-value= 7.84, f2 = 0.161).
Multiscale Intelligent Inversion of Water-Conducting Fractured Zone in Coal Mine Based on Elastic Modulus Calibration Rate Response and Its Application: A Case Study of Ningdong Mining Area
Authors: Xu Huicong , Lai Xingping , Zhang Shuai , Zhang Yun , Shan Pengfei , Zhang Xudong , Liu Bowei , Wan Peifeng 
Published: November 2021

Abstract
Water-conducting fractured zone is the direct inducement of water inrush, water losing, and environmental deterioration in coal mines. How to predict the height of water-conducting fractured zone economically and accurately has always been the research difficulty of water-preserved mining. The paper selects the Meihuajing coal mine in Ningdong mining area as the engineering background. Firstly, transform the distribution law of the water-conducting fractured zone into a deterioration mechanism of coal-rock strength under the action of water-rock. Through laboratory tests, the water-rock coupling degradation law of rock mass under uniaxial action is revealed, and an intelligent statistical model of damage rate response under different water content is proposed. Secondly, based on the cross-scale elastic modulus calibration principle and the rate response intelligent statistical model proposed above, the borehole elastic modulus instrument is used to quantitatively characterize the strength characteristics of elastic modulus rate response law and field lithological parameters. Finally, based on the 18 samples of the water-conducting fractured zone, a height prediction model of a water-conducting fractured zone based on the measured value of elastic modulus is proposed by using the method of PSO-SVR. Taking R2 and RMSE as evaluation indexes, the error comparison between PSO-SVR and the empirical formula is carried out. Research indicates that, compared with the empirical formula, R2 of the PSO-SVR model increased by 18.3% and RMSE decreased by 92.7%. The predicted value of the PSO-SVR is consistent with the measured value, which significantly improves the prediction accuracy of the height of the water-conducting fractured zone. It provides a theoretical basis and technical support for the coordinated development of safe and efficient development of coal and ecological protection in Ningdong mining area.
News Events and Their Relationship With US Vape Sales: An Interrupted Time Series Analysis
Authors: Janmohamed Kamila , Sakai Shinpei Nakamura , Soale Abdul-Nasah , Forastiere Laura , Kumar Navin 
Published: November 2021

Abstract
Objective News coverage around vaping-related events may have furthered misconceptions regarding the relative harms of vapes. Such information may influence the decisions of individuals who smoke, around switching to vaping, potentially affecting the overall tobacco mortality burden. Thus, it is prudent to study how news events (e.g., 2019 vaping illness epidemic) are associated with vape sales in the United States, to possibly reduce the tobacco mortality burden. Methods We used weekly retail sales data for e-cigarettes (30 December 2018 - 28 December 2019) from the US retail scanner data compiled by the Nielsen Company. We used an interrupted time series design with segmented regression analysis to determine immediate and longer-term impacts of individual news events (e.g. Trump administration's planned ban on flavored vaping products) on vape sales, controlling for pre-existing trends.Results Unexpectedly, we noted a statistically significant positive relationship between vape sales and the CDC announcing an investigation into vaping-related illnesses (Change: 6.59%, Estimate: 0.064; 95% CI: 0.036, 0.092; P<0.001). We also observed a similar positive association between vape sales and the CDC's announcement on the link between Vitamin E acetate and EVALI (Change: 2.93%, Estimate: 0.029; 95% CI: 0.003, 0.055; P<0.05). There was a steep decline in sales after these events.ConclusionsNews events are associated with US vape sales. Findings have implications for the management of risk perceptions around vaping to improve health outcomes of tobacco users. Information-based policy instruments can be applied to balance the effects of news events that may influence vape sales.
Chimeric CNS-Targeting-Peptide Engineered Exosomes for Experimental Allergic Encephalomyelitis Therapy
Authors: Wang Yingkai , Zhao Yunpeng , Ye Mingzhu , Wang Ling , Lan Tianshu , Wang Yue , Qi Zhongquan 
Published: November 2021

Abstract
Background: Multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS), leads to demyelination, neuronal injury, and loss of white matter, yet still can't be cured. Exosomes are double-layered membrane vesicles of 30–200 nm in size, which can easily penetrate the blood–brain barrier (BBB). Exosomes derived from umbilical cord mesenchymal stem cells exosomes (UMSC-exos) has been shown to treat experimental autoimmune encephalomyelitis (EAE) through the action of anti-inflammatory and immunomodulatory, but its clinical translation has been hampered by their inefficacious accumulation in CNS. Therefore, we developed a TAxI-peptide-chimeric UMSC-exos termed TAxI-exos for CNS-specific accumulation and curative effect in EAE.Methods: We used an EAE model in vivo, and actived T cells and BV-2 cells models in vitro. After two immunizations to establish the EAE model, UMSC-exos, TAxI-exos or DiR labeled exosomes were administered to EAE mice EAE mice for one dose (150μg) before the peak at day 15. On day 30, the mice were sacrificed to collect spinal cords, spleens, and blood for analysis of demyelination, inflammation, microglia, the proportions of T-cell subsets, and the expression of inflammatory cytokines. In vitro, for immune mechanism analyses, PBMCs and splenocytes isolated from healthy C57BL/6 mice, were activated and incubated with 0.15mg/mL UMSC-exos or TAxI-exos. Activated BV-2 cells were used to explore the targeting-ability and polarization-regulating ability of UMSC-exos and TAxI-exos.Results: As expected, TAxI-exos had significant curative effects in EAE mice compared with UMSC-exos via an enhanced targeting-ability. The treatment alleviated inflammation, facilitated microglial cell polarization from M1 to M2, reduced the proportions of T-cell subsets, increased the expression levels of IL-4, IL-10, TGF-β, and IDO-1, and decreased the levels of IL-2, IL-6, IL-17A, IFN-γ, and TNF-α. Conclusions: TAxI-exos have a great CNS-targeting ability and suppress pathological processes in EAE mice, which have a great potential therapeutic utility for MS and other CNS diseases.
AKR1C3 Expression in T and B Acute Lymphoblastic Leukemia/Lymphoma for Clinical Use as a Biomarker
Authors: Reddi Deepti , Seaton Brandon , Woolston David , Aicher Lauri , Monroe Luke , Mao Zhengwei , Harrell Jill , Radich Jerald , Advani Anjali , Papadantonakis Nikolaos , Yeung Cecilia 
Published: November 2021

Abstract
Objectives: To investigate aldo–keto reductase 1C3 (AKR1C3) expression in T and B acute lymphoblastic leukemia/lymphoma (ALL) patients.Methods: Three commercial antibodies were evaluated for AKR1C3 immunohistochemistry (IHC) staining performance: Polyclonal Thermofisher scientific (Clone#PA523667), rabbit monoclonal Abcam [EPR16726] (ab209899) and Sigma/Millipore anti-AKR1C3 antibody, mouse monoclonal, clone NP6.G6.A6, purified from hybridoma cell culture. Initial optimization was performed on cell line controls: HCT116 (negative control); genetically modified cell line HCT116 with AKR1C3 overexpression; Nalm and TF1 cell lines. Twenty normal bone marrows from archival B and T-ALL patient samples were subsequently examined. AKR1C3 expression levels in these samples were evaluated by immunohistochemistry, Protein Wes and quantitative RT-PCR.Results: Sigma/Millipore Anti-AKR1C3 antibody (mouse monoclonal, clone NP6.G6.A6) showed higher specificity compared to rabbit polyclonal antibody by immunohistochemistry. H-score was used to quantify percent of nuclear immunoreactivity for AKR1C3 with varying disease involvement. T-ALL samples had a higher H-score (172-190) compared to B-ALL cases (H-score, 30-160). The AKR1C3 expression in peripheral blood by Protein Wes and RT-qPCR showed concordance in relapsed/refractory and/or minimal residual T-ALL cases. Conclusions: Sigma/Millipore Anti-AKR1C3 antibody and mouse monoclonal, clone NP6.G6.A6 can be used to aid in AKR1C expression of T-ALL and in cases of relapsed/refractory and/or minimal residual disease.
Potassium Permanganate Dye Removal from Synthetic Wastewater Using A Novel, Low-Cost Adsorbent, Modified from The Powder of Foeniculum Vulgare Seeds
Authors: Bani-Atta Suhair 
Published: November 2021

Abstract
Seeds powder of Foeniculum vulgare (FVES) was used to prepare a novel adsorbent, the new adsorbent was characterized and its ability to eliminate potassium permanganate (KMnO 4 ) was examined. The impact of KMnO 4 concentration, adsorbent dose, contact temperature, contact time, and solution pH on the adsorption performance was also investigated. The experimental data of this adsorption was analyzed by different kinetic and isotherm models. As Constants of thermodynamic ΔG°, ΔH°, and ΔS° have been also evaluated. Surface area, pore volume, and pore size of the FVESP adsorbent were determined as 0.6806 m 2 .g -1 , 0.00215 cm 3 .g -1 , and 522.063 Å, as pH ZPC of Ox- FVESP was stated to be 7.2. The R 2 values obtained from applying different isotherm and kinetic models (0.999 and 0.996) showed that the adsorption performance of KMnO 4 follows the Langmuir and Pseudo 2 nd order models. Furthermore, high adsorption capacities of 1111.11, 1250.00, and 1428.57 (mg/g) were achieved at three temperatures that were used in this study. Constants of thermodynamic ΔG°, ΔH°, and ΔS° values indicate chemical and spontaneous adsorption at the adsorbent surface.
Analytical solution for low energy state estimation by quantum annealing to arbitrary Ising spin Hamiltonian
Authors: Yan Bin , Sinitsyn Nikolai 
Published: November 2021

Abstract
We point to the existence of an analytical solution to a general quantum annealing (QA) problem of finding low energy states of an arbitrary Ising spin Hamiltonian HI by implementing time evolution with a Hamiltonian H(t) = HI + g(t)Ht. We will assume that the nonadiabatic annealing protocol is defined by a specific decaying coupling g(t) and a specific mixing Hamiltonian Ht that make the model analytically solvable arbitrarily far from the adiabatic regime. In specific cases of HI, the solution shows the possibility of a considerable quantum speedup of finding the Ising ground state. We then compare predictions of our solution to results of numerical simulations, and argue that the solvable QA protocol produces the optimal performance in the limit of maximal complexity of the computational problem. Our solution demonstrates for the most complex spin glasses a power-law energy relaxation with the annealing time T and uncorrelated from HI annealing schedule. This proves the possibility for spin glasses of a faster than ∼ 1/logβT energy relaxation.
Missing data on ethnicity and socioeconomic status in high-impact medical journals
Authors: Buttery Sara , Philip Keir , Alghamdi Saeed , Williams Parris , Quint Jennifer , Hopkinson Nicholas 
Published: November 2021

Abstract
Reporting participant ethnicity and socioeconomic status (SES) in clinical research is needed for interpretation and to inform discussion around health inequalities. We assessed the frequency of reporting of ethnicity (or ‘race’) and SES indicators in a sample of 100 research articles, in which participant level are reported, published in the 10 highest impact general medical journals in Spring 2021. 35 reported ethnicity and 13 SES, while 99 reported age, and 97 reported sex or gender. Among the articles not reporting ethnicity only 3(5%) highlighted this as a limitation, and only 6(7%) where SES data were missing. Median number of articles reporting ethnicity per journal was 2.5/10 (range 0-9). In conclusion, reporting of research participant ethnicity and socioeconomic status in high-impact medical journals remains poor, and this omission is rarely acknowledged as a limitation. This situation persists despite the well-established importance of this issue. Standardized explicit minimum standards are required.
Assessment of Calcium and Vitamin D Medications Adherence in Patients with Hypoparathyroidism After Thyroidectomy
Authors: Bilginer Muhammet Cuneyt , Aydin Cevdet , Polat Burcak , Faki Sevgul , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir 
Published: November 2021

Abstract
Summary: In this study, we found that patients with hypoparathyroidism had a problem with calcium medication compliance, and this problem increased with the duration of the disease. We also showed that patients are concerned about the possible side effects of drugs.Introduction: In this study, we aimed to evaluate adherence to avtive vitamin D and calcium replacement in patients with post surgical hypoparathyroidism.Methods: To elucidate the medication adherence, we performed a questionnaire survey using the six item “Medication adherence questionnaire’’(MAQ). The first, second and sixth questions reflect the motivation status of the patients whereas the third, forth and sixth questions reflect the knowledge about the medication that is received. The responses are scored and patients are classified regarding their motivation to and knowledge about the particular drug.Results: Totally 64 patients (Male:12/Female:52; mean age 48.6±11.6 years) who had postoperative hypoparathyroidism were included in our study. Median disease durance was 60 months (min-max; 12-295 months). We found that motivation score of calcium usage was significantly lower compared to vitamin D usage (p<0.001). The calcium motivation score was reversely correlated with disease duration (r= -0.256 and p=0.046). The most common worry about calcium usage was nephrotoxicity, and the most common worries about calcitriol treatment were kidney damage and polyuria. One third of the patients were taking oral calcium and calcitriol less than the recommended dose.Conclusion: One third of patients lack motivation to use calcium whereas half of the patients’ experiences anxiety about drug related side effects. This is a preliminary study showing that vital calcium and active vitamin D intake may be interrupted due to side effect anxiety and motivation can be increased by frequent visits and acknowledging the patient about the deleterious effects of drug withdrawal.