bluuebunny/crossref_metadata_2025_split huggingface dataset:
F-18 Fluorodeoxyglucose PET/CT as a Diagnostic Tool in Orbital Inflammatory Disorders
Authors: Elourimi Ghassan , Soussan Michael , Groh Matthieu , Martin Antoine , Héran Françoise , Galatoire Olivier , Dhote Robin , Vicaut Eric , Abad Sébastien 
Published: January 2021

Abstract

Background: In the last decade, FDG-PET/CT has become routine practice in the management of lymphoma or autoimmune diseases. In the current study, we aimed to assess the usefulness of FDG-PET/CT as a potential diagnostic tool for detecting underlying systemic diseases (SD) in patients with orbital inflammatory disorders (OID).Methods: All consecutive patients managed for new-onset OID between 2011 and 2018 in a tertiary referral center for OID, who underwent FDG-PET/CT as part as the etiological diagnostic workup were enrolled. PET-FDG/CT scans were reviewed blindly and were considered as positive for SD detection if they showed lymphadenopathy and/or other visceral lesions with an uptake above blood pool background. We used the standard diagnostic workup (performed in all patients at presentation) as relevant comparator. To quantify the incremental value of FDG-PET/CT over the standard diagnostic workup, the Net Reclassification Index (NRI) and Integrated Discrimination Index (IDI) were used. The final diagnosis was based on international criteria for autoimmune diseases, or histological confirmation for lymphoma, xanthogranuloma, crystal storing histiocytosis (CSH), or idiopathic orbital inflammation syndrome (IOIS). Results: Among the 22 patients enrolled, 14 (63%) had underlying SD (granulomatosis with polyangiitis (GPA), n=1; IgG4-related disease (IgG4-RD), n=5; CSH, n=1; adult onset asthma and periocular xanthogranuloma (AAPOX), n=3; lymphoma, n=4) while the remaining 8 (37%) patients were diagnosed with IOIS. Eleven (50%) patients had a positive FDG-PET/CT. After clinicobiological evaluation, FDG-PET/CT correctly reclassified 29% of patients with SD (p=0.04) and 13% with IOIS (p=0.3), corresponding to an elevated NRI of 0.41±0.17 (p=0.03). The IDI test used to evaluate the improvement of FDG-PET/CT for SD detection was 0.38±0.08 (p<0.001). After FDG-PET/CT, probability changes for SD and IOIS were measured at 0.14 and -0.24, respectively (relative gain of 3.04 for IDI). FDG-PET/CT successfully detected asymptomatic lesions in all patients with a final diagnosis of lymphoma. Conclusion: FDG-PET/CT enabled accurate reclassification of more than one quarter of patients with SD, suggesting its potential value for detecting SD (especially extraorbital lymphoma).
Efficacy of Quetiapine for Delirium Prevention in Hospitalized Older Medical Patients: a Randomized Double-blind Controlled Trial
Authors: Thanapluetiwong Saran , Ruangritchankul Sirasa , Sriwanno Orapitchaya , Chansirikarnjana Sirintorn , Ittasakul Pichai , Ngamkala Tipanetr , Sukumalin Lalita , Charernwat Piangporn , Saranburut Krittika , Assavapokee Taweevat 
Published: January 2021

Abstract
Background: Delirium is a common disorder among hospitalized older patients and results in increased morbidity and mortality. The prevention of delirium is still challenging in older patient care. The role of antipsychotics in delirium prevention has been limited. Therefore, we conducted a trial to investigate the efficacy of quetiapine use to prevent delirium in hospitalized older medical patients.Methods: This study was a randomized double-blind controlled trial conducted at Ramathibodi Hospital, Bangkok, Thailand. Patients aged ≥ 65 years hospitalized in the internal medicine service were randomized to quetiapine 12.5 mg or placebo once daily at bedtime for a maximum 7-day duration. The primary end point was delirium incidence. Secondary end points were delirium duration, length of hospital stay, ICU admission, rehospitalization and mortality within 30 and 90 days.Results: A total of 122 patients were enrolled in the study. Eight (6.6%) left the trial before receiving the first dose of the intervention, whereas 114 (93.4%) were included in an intention-to-treat analysis allocated to the quetiapine or placebo group (n=57 each). The delirium incidence rates in the quetiapine and placebo groups were 14.0% and 8.8% (OR=1.698, 95% CI 0.520-5.545, P=0.381), respectively. Other endpoints in the quetiapine and placebo groups were the median length of hospital stay, 6 (4-8) days versus 5 (4-8) days (P=0.133), respectively; delirium duration, 4 (2.3-6.5) versus 3 (1.5-4.0) days (P=0.557), respectively; ICU admission, 3 (5.3%) patients from both groups (P=1.000); and mortality in the quetiapine and placebo groups, 1 (1.8%) versus 2 (3.5%) at 30 days (P=0.566) and 7 (12.3%) versus 9 (15.8%) days at 90 days (P=0.591). There were no significant differences in other outcomes. None of the participants reported adverse events.Conclusions: Quetiapine prophylaxis did not reduce delirium incidence in hospitalized older medical patients. The use of quetiapine to prevent delirium in this population group should not be recommended.Trial registration: This trial was retrospectively registered with the Thai clinical trials registry (TCTR) at clinicaltrials.in.th (TCTR20190927001) on September 26, 2019.
Hemodynamic Analysis for Endovascular Treatment in Small Unruptured Intracranial Aneurysms: A Matched Comparison Study of Flow Diverter Versus LVIS
Authors: Liu Jian , Li Wenqiang , Zhang Yisen , Wang Kun , Yang Xinjian , Zhang Ying 
Published: January 2021

Abstract
BackgroundWe compared the treatment of small unruptured intracranial aneurysms (UIAs) with flow diverter and LVIS assisted coiling to determine the effects of hemodynamic changes caused by different stent and coil packing in endovascular treatment.MethodsFifty-one UIAs in 51 patients treated with pipeline embolization device (PED) were included in this study, and defined as the PED group. We matched controls 1:1 and enrolled 51 UIAs who treated with LVIS stent, which defined as the LVIS group. Computational fluid dynamics were performed to assess hemodynamic alterations between PED and LVIS. Clinical analysis was also performed between these two groups after the match.ResultsThere was no difference in procedural complications between two groups (P=0.558). At the first angiographic follow-up, the complete occlusion rate was significantly higher in the LVIS group compared with that in the PED group (98.0% vs 82.4%, P = 0.027). However, during the further angiographic follow-up, the complete occlusion rate in PED group achieved 100%, which was higher than that in LVIS group (98.0%). Compared with the LVIS group after treatment, cases in PED group showed a higher value of velocity in the aneurysm (0.03 ± 0.09 vs 0.01 ± 0.01, P=0.037) and WSS on the aneurysm (2.32 ± 5.40 vs 0.33 ± 0.47, P=0.011). Consequently, the reduction ratios of these two parameters were also showed statistical differences. These parameters in LVIS group showed much higher reduction ratios. However, the reduction ratio of the velocity on the neck plane was comparable between two groups. ConclusionsBoth LVIS and PED were safe and effective for the treatment of small UIAs. However, LVIS-assisted coiling produced greater hemodynamic alterations in the aneurysm sac compared with PED. The hemodynamics in the aneurysm neck may be a key factor for aneurysm outcome.
Biomechanical Study of Tile C3 Pelvic Fracture Fixation Using an Anterior Internal System Combined With Sacroiliac Screws
Authors: liu lin , Zeng Donggui , Fan Shicai , Peng Yongxing , Song Hui , Jin Dadi , Zeng Letian 
Published: January 2021

Abstract
BackgroundThis study aimed to investigate the effectiveness of different methods of fixation of Tile C3 pelvic fractures. We applied minimally-invasive treatment using an anterior internal fixator combined with sacroiliac screws. ObjectivesTo compare the biomechanical properties of different fixation models in pelvic facture specimens, using an internal fixation system or a steel plate combined with sacroiliac screws. MethodsSixteen fresh adult cadaver pelvic specimens were randomly separated into four groups named A, B, C and D. The four groups were respectively stabilized using a two-screwed, three-screwed, or four-screwed anterior internal fixator or a steel plate with sacroiliac screws. All models were tested in both standing and sitting positions. Vertical loads of 600 N were applied increasingly. Shifts of bilateral sacroiliac joints and pubis rupture were measured. ResultsThe shifts in sacroiliac joints and pubis rupture in the standing position were all less than 3.5 mm and the shifts in the sitting position were all less than 1 mm. In the standing position, the results of shifts in the sacroiliac joints were: Group C < Group D < Group B < Group A. For comparisons between A:B and C:D, P > 0.05. For comparisons between A, B:C, D, P < 0.05. The results of shifts in pubis ruptures were: Group D < Group C < Group B < Group A. In the comparison between C:D, P > 0.05, for comparisons between A:B, A:C, A:D, B:C, and B:D, P < 0.05. In the sitting posture, the results of shifts in the sacroiliac joints were: Group C < Group D < Group B < Group A, the shifts in the pubis ruptures were: Group D < Group C < Group B < Group A. For comparison between C:D, P > 0.05. For comparisons between A:B, A:C, A:D, B:C, and B:D, P < 0.05. ConclusionUse of an anterior internal fixator combined with sacroiliac screws effectively stabilized Tile C3 pelvic fractures. Among the options tested, a two-screwed internal fixator combined with sacroiliac screws was easier to operate. The stability of specimens increased as the number of screws in the internal fixator increased.
Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice
Authors: Sun Shihui , He Lei , Zhao Zhongpeng , Gu Hongjing , Fang Xin , Wang Tiecheng , Yang Xiaolan , Chen Shaolong , Deng Yongqiang , Li Jiangfan , Zhao Jian , Li Liang , Li Xinwang , He Peng , Li Ge , Li Hao , Zhao Yuee , Gao Chunrun , Lang Xiaoling , Wang Xin , Fei Guoqiang , Li Yan , Geng Shusheng , Gao Yuwei , Wei Wenjin , Hu Zhongyu , Han Gencheng , Sun Yansong 
Published: January 2021

Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to infect people globally. The increased COVID-19 cases and no licensed vaccines highlight the need to develop safe and effective vaccines against SARS-CoV-2 infection. Multiple vaccines candidates are under pre-clinical or clinical trails with different strengths and weaknesses. Here we developed a pilot scale production of a recombinant subunit vaccine (RBD-Fc Vacc) with the Receptor Binding Domain of SARS-CoV-2 S protein fused with the Fc domain of human IgG1. RBD-Fc Vacc induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and mice, and the antibodies induced in macaca fascicularis neutralized three divergent SARS-CoV2 strains, supporting broader neutralizing ability. Three times immunizations protected Macaca fascicularis (20ug or 40ug per dose) and mice (10ug or 20ug per dose) from SARS-CoV-2 infection respectively, including the protection against SARS-CoV-2 adapted virus MASCp6 which contains N501Y mutation, a key residue increasing binding affinity to human and murine ACE2. These data support clinical development of SARS-CoV-2 vaccines and provide a promising strategy to prevent different stains of SARS-CoV-2 infection. RBD-Fc Vacc is currently being assessed in randomized controlled phase 1/II human clinical trails
The Circulating Levels of CTRP1 and CTRP5 Are Associated with Obesity Indices and Carotid Intima-Media Thickness (cIMT) Value in Patients with Type 2 Diabetes: A Preliminary Study
Authors: Majidi Ziba , Emamgholipour Solaleh , Omidifar Abolfazl , Fard Soheil Rahmani , Poustchi Hossein , Shanaki Mehrnoosh 
Published: January 2021

Abstract
Background: There is growing evidence that the C1qTNF-related protein (CTRP) family has a crucial role in the physiology and pathophysiology of metabolic disorders such as Type 2 Diabetes (T2D) and obesity. We sought to identify the association of CTRP1 and CTRP5 circulating levels with various obesity parameters such as visceral adipose tissue (VAT) thickness, visceral adiposity index (VAI), and with carotid intima-media thickness (cIMT) in patients with T2D and healthy subjects. Methods: This preliminary study consisted of men with T2D (n=42) and men without T2D (n=42). cIMT and VAT thickness measurement was performed using an Accuvix XQ ultrasound. Circulating levels of CTRP1, CTRP5, and adiponectin were measured by enzyme-linked immunosorbent assay (ELISA).Results: CTRP-1 and CTRP1/CTRP5 ratio was markedly higher in patients with T2D compared to controls (p < 0001 and p = 0004 respectively). Interestingly, binominal logistic regression revealed that a higher circulating level of CTRP1 was associated with the presence of T2D (odds ratio [OR]: 1.009 [95% CI: 1.004-1.015]; P=.001). CTRP1 circulating levels were correlated with WHR, VAT, and HOMA-IR in the whole population study. Also, we observed that the ratio of CTRP1 to CTRP5 in plasma (β = 0.648, P=0.005) and CTRP5 circulating levels (β = 0.444, P=0.049) are independently associated with cIMT value.Conclusions: Our results indicated that CTRP1 and CTRP5 concentrations were correlated with atherosclerosis in men with T2D and these adipokines might have a causal role for cardiometabolic risk in T2D.However, more studies in large sample sizes are required to clarify the role of CTRPs in T2D pathogenesis.
Effects of active gases on droplet transfer and weld morphology in pulsed-current NG-GMAW of mild steel
Authors: Liu Guoqiang , Tang Xinhua , Xu Qi , Lu Fenggui , Cui Haichao 
Published: January 2021

Abstract
The current research of narrow-gap gas metal arc welding (NG-GMAW) primarily focuses on improving the sidewall fusion and avoiding the lack-of-fusion defect. However, the high cost and operation difficulty of the methods limit the industrial application. In this study, small amount of active gases CO2 and O2 were added into pure argon inert shielding gas to improve the weld formation of pulsed-current narrow-gap gas metal arc welding (NG-GMAW) of mild steel. Their effects on droplet transfer and arc behavior were investigated. A high-speed visual sensing system was utilized to observe the metal transfer process and arc morphology. When the proportion of CO2, being added into the pure argon shielding gas, changes from 5% to 25%, the metal transfer mode changes from pulsed spray streaming transfer to pulsed projected spray transfer, while it remains the pulsed spray streaming transfer when 2% to 10% O2 is added. Both CO2 and O2 are favorable to stabilizing arc and welding process. O2 is even more effective than CO2. However, O2 is more likely to cause slags on the weld surface, while CO2 can improve the weld appearance in some sense. The weld surface concavity in NG-GMAW is greatly influenced by the addition of active gas, but the weld width and weld penetration almost keep constant. This study proposes a new method which is beneficial to improving the weld bead formation and welding process stability.
Measuring PrEP Preferences Among U.S. Military Men Who Have Sex with Men: Results of an Adaptive Choice Based Conjoint Analysis Study
Authors: Gutierrez Jose I , Dubov Alex , Altice Frederick , Vlahov David 
Published: January 2021

Abstract
Background Pre-exposure prophylaxis (PrEP) effectively prevents HIV infection, yet its uptake remains low among U.S. military men who have sex with men (MSM). Research shows that health services matching preferences produce favorable outcomes. Therefore, an early step for planning program design is to characterize and identify preferences for improved PrEP delivery within this population. Methods HIV-negative military MSM were recruited through a closed, LGBT military social media group. Participants completed an anonymous survey presenting five experimentally varied attributes of interest related to PrEP administration (dosing method, provider type, visit location, lab work evaluation location, and dispensing venue). Relative importance and part-worth utility scores were generated using Hierarchical Bayes (HB) estimation, and the randomized first choice model was used to examine participation interest across eight possible PrEP program scenarios.Results Among the 429 participants and the eight scenarios that varied the five attributes into delivery profiles, the most preferred scenarios featured a daily tablet, PrEP injection, or PrEP implant, along with a military provider, smartphone/telehealth visit, and on-base locations for lab evaluation and medication pick-up. Responses emphasized the importance for providers to be familiar with PrEP prescription knowledge, and to provide interactions sensitive to sexual identity and mental health.Conclusion These results suggest that a daily tablet PrEP program within a military healthcare setting is preferred over a civilian or off-site one, yet more importantly, it points to a high value placed on the quality of clinical interactions. High interest in long-acting implants and injections also suggest potential markets for future PrEP engagement.
Findings and Feasibility of Major Salivary Gland Ultrasound in Childhood-Onset Systemic Lupus Erythematosus: A Pilot Study
Authors: McDonald Joseph , Vega-Fernandez Patricia , Ting Tracy 
Published: January 2021

Abstract
Background: Childhood-onset systemic lupus erythematosus (cSLE) is a complex autoimmune disorder with multi-organ manifestations and can be associated with other rheumatic diseases including Sjögren’s syndrome (SS). Salivary gland ultrasound (SGUS) represents a noninvasive tool to screen for salivary gland disease in rheumatic disease patients. The aims of this cross-sectional study were to determine feasibility of major SGUS in a clinic setting and to identify characteristics in a cohort of cSLE patients (without confirmed SS) that may be associated with salivary gland abnormalities consistent with secondary SS.Methods: Patients with SLE onset prior to age 18 were recruited. Patients completed questionnaires rating symptoms and underwent major SGUS examination. Disease and demographic differences were compared between cSLE patients with abnormal SGUS vs. cSLE patients with normal SGUS using t-tests and Fisher’s exact tests.Results: 31 cSLE patients were recruited, 84% were female, 55% were Caucasian. The average disease duration among all patients was 5 years. Average time to complete the SGUS examination and scoring protocol was 7 minutes. 35% of SGUS scores were abnormal and significantly associated with IgG level at diagnosis, and anti-Ro and anti-La antibodies.Conclusions: This is one of the first studies to our knowledge that assesses major SGUS in a cohort of patients with cSLE without prior diagnoses of SS. The SGUS protocol was feasible to perform by rheumatologists in a clinic setting. Although the sample size was small, SGUS abnormalities were identified in one-third of patients. IgG level at diagnosis and anti-Ro and anti-La antibodies may be associated with SGUS abnormalities.
Optimizing Access to Financial Capital of Creative Economy for Startups Towards Global Competitiveness
Authors: Santoso Sugeng 
Published: January 2021

The lack of understanding of the financial capital of the creative economy regarding non-bank financial institutions limits the growth of Indonesia’s creative economy. Strategies through policies, capital owners, creative economy players and bring together capital owners with players. The capital of the creative economy is represented on the criteria: entrepreneurial characteristics, product/service characteristics, market characteristics, and financial characteristics. The method used is a qualitative analysis and quantitative analysis which starts from data collection, data analysis, participatory discussion, drawing conclusions, formulating policies and stakeholder synergy. The startup mentoring scoring instrument is a framework for investor’s decision making to invest in the startup. 3 scoring elements of mentoring startup scoring: Product & key person with a weight of 55%, Traction with a weight of 25%, and Investment with a weight of 20%. Primary data were obtained by participatory observation, field studies, and key informant interviews through startup mentoring programs, workshops, and startup competitions. Results: Among 20% of startups pitched in front of investors, there are 11% of startups that investors interested in and got funding from a consortium of Indonesian and foreign venture capital companies. Matchmaking activities increase added value, and the implemented policy also increases added value.
Investigation for synchronization characteristics of double cam vibrating screen
Authors: Hou Yongjun , Zou Rui , Fang Pan , Liu Youping , Peng Hong , He Yinkai 
Published: January 2021

Aiming at the shortcomings of traditional vibrating screens with large vibration mass, a double eccentric cam self-synchronous vibrating screen is proposed. The motion differential equation of the vibrating screen system is derived by using Lagrange equation and the steady state solution is obtained. According to Hamilton principle, the synchronization condition of the vibration system is deduced, and the stability condition of the self-synchronization motion is obtained. The influencing factors of synchronization and stability are investigated by using numerical calculation and simulation analysis methods. The results show that stable self-synchronous motion of the vibration system is implemented when the synchronization and stability conditions are satisfied; the value of the stable phase difference of two cams varies in the range of (–1.5 rad, 0), and compared with the residual torque difference, the eccentricity of eccentric cams has a greater impact on the stable phase difference; additionally, a linear motion track of the vibrating screen is achieved.