bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstruction of Tsunami Occurrence on Okushiri Island, Southwestern Hokkaido, Japan
Authors: Urabe Atsushi , Kase Yoshihiro , Kawakami Gentaro , Nishina Kenji , Takashimizu Yasuhiro , Miyazawa Hiroyuki , Hirano Fumika 
Published: October 2021

Abstract
The eastern margin of the Japan Sea is located along an active convergent boundary between the North American and Eurasian tectonic plates. Okushiri Island, which is situated off the southwest coast of Hokkaido, is located in an active tectonic zone where many active submarine faults are distributed. Studying the records of past tsunamis on Okushiri Island is important for reconstructing the history and frequency of fault activity in this region, as well as the history of tsunamis in the northern part of the eastern margin of the Japan Sea. Five tsunami deposit horizons have been identified previously on Okushiri Island, including that of the 1741 tsunami, which are interbedded in the coastal lowlands and Holocene terraces. However, these known tsunami deposits date back only ~3,000 years. A much longer record of tsunami occurrence is required to consider the frequency of submarine fault activity. In this study, we cored from 7 to 25 m depth in the Wasabiyachi lowland on the southern part of Okushiri Island, where previous studies have confirmed the presence of multiple tsunami deposits on peat layer surfaces. The results indicate that the Wasabiyachi lowland comprises an area that was obstructed by coastal barriers between the lowland and the coast at ~8.5 ka and consists of muddy sediment and peat layers formed in lagoons and floodplains, respectively. In addition, event deposits and 15 tsunami horizons were observed among the turbidites and peat layers, dating back as far as 3,000 years. Combined with previous findings, Okushiri Island has sustained 20 tsunami events between ~7.5 ka and the present. These findings are critical for investigating the activities of submarine faults off the southwestern coast of Hokkaido, as well as for determining tsunami risks along the coast of the Japan Sea between North Tohoku and Hokkaido.
Association Between Vertebral Segmental Artery Occlusion and Kummell Disease: A Prospective Cohort Study Based On MRA
Authors: Zhan Sizheng , Zhang Tianyu , Xie Wenyong , Xue Feng , Zhang Dianying , Jiang Baoguo 
Published: October 2021

Abstract
Purpose

We designed a prospective cohort study based on magnetic resonance angiography (MRA) to identify whether the degree of Kummell disease (KD) vertebral artery occlusion is more severe than that of simple vertebral compression fractures.
Methods

We enrolled elderly patients with VCFs who met the established criteria from January 2019. MRA was used to determine the degree of vertebral artery occlusion. We defined the lesion segmental occlusion rate (LSOR) as the sum of the ischemic values of the bilateral vertebral segmental arteries (0 means expedite, 1 means stenosis, 2 means occlusion; range from 0–4). The average LSOR is the sum of LSORs divided by the number of vertebrae. Follow-up outcomes included VAS and ODI scores after surgery. X-rays were re-examined at 1 year after surgery to determine whether the vertebral body had recollapsed.
Results

25 cases of KD segments and 37 cases of non-KD segments were included. The average LSOR in KD segments was significantly higher than that in non-KD segments (1.44 vs 0.32, P<0.01). The recollapse rate of the KD segments after one year was significantly higher than that in non-KD segments (56% vs 27%, P=0.03). In non-KD segments, 57.1% of segments with a high LSOR (1–2) recollapsed, and 20% of segments with a low LSOR (0) recollapsed (P=0.045)
Conclusions

The degree of artery occlusion in the KD segment is more serious than that in the non-KD segment. KD segments or non-KD segments with a high degree of artery occlusion will have a higher recollapse rate.
Oral Hygiene Practices and their Socio-demographic Correlates among Adults in Burkina Faso: Results from the First National Survey
Authors: Diendéré Jeoffray , Ouattara Seydou , Kaboré Jean , Traoré Ibrahim , Zeba Augustin Nawidimbasba , Kouanda Séni 
Published: October 2021

Abstract
Background: Socio-demographic parameters are the driving determinants for oral hygiene practices. This purpose aims to describe oral hygiene practices and associated socio-demographic factors in Burkinabè population, using the first nationally-representative data.Methods: This descriptive, cross-sectional study included 4677 adults through multistage cluster sampling performed during the first WHO STEPS survey conducted in 2013 in Burkina Faso. The practices we considered were the frequencies of tooth cleaning, the fluoridated toothpaste use and a dentist visit within the last six months. Sociodemographic variables and oral hygiene practices were described and the first ones were used as the explanatory variables for the seconds in the multivariable analyses. Results: Individuals who cleaned teeth at least once a day represented 82.8% and at least twice a day 31.4%; those who used fluoridated toothpaste were 25.6% and 2.1% have visited a dentist. With the highest odds-ratio, only being educated was a favorable factor for each of oral hygiene practices. Living in an urban area or being younger adults were favorable factors to the daily repetitive tooth cleaning or the use of a fluoridated paste. Female gender applied more to a daily repetitive cleaning, as well as to the dentist visit.Conclusion: Cleaning teeth at least once a day was common among Burkinabè while cleaning at least twice a day, the use of fluoridated paste or dentist visiting were infrequent. Education was the key favorable determinant for healthy oral hygiene practices and improving oral health literacy interventions through basic health education should be promoted.
Energy Evolution and Water Immersion-Induced Weakening Mechanism in the Sandstone Roof of Coal Mines
Authors: Liu Wenjie , Yang Ke , Zhang Shuai , Zhang Zhainan , Xu Rijie 
Published: October 2021

Abstract
The instability of underground spaces in abandoned coal mines with water-immersed rocks is one of the main hazards hindering the geothermal energy utilization and ecological restoration of post-mining areas. This study conducted graded cyclic loading-unloading tests of five groups of sandstone samples with different water contents. The evolution laws of input, elastic, dissipated, damping, and plastic energies were explored in detail, taking into account the damping effect. The normalized plastic energy was used to characterize the damage evolution of sandstone samples, which failure modes were analyzed from both macroscopic and microscopic perspectives. The X-ray diffraction technique and scanning electron microscopy were used to reveal the softening mechanism of sandstone's strength and elastic energy storage limit. The results showed that the graded cyclic loading's input, elastic, and dissipated energies increased gradually. The elastic energy share first increased and then stabilized, while dissipated energy share variation had the opposite trend. In each cycle, the input energy was primarily stored in the form of elastic energy, while the dissipated energy was mainly used to overcome the damping of sandstone. When the normalized number of cycles approached unity, the plastic energy share sharply increased, while that of the dampening energy featured an abrupt drop. Such change indicated an inevitable instability failure of the water-bearing sandstone. As the water content increased, the pore water exhibited more substantial lubrication, water-wedging, and dissolution effects on mineral particles. As a result, the latter obtained a round form, and the elastic energy storage limit of the sandstone decreased. When the water content was increased, the damage factor of sandstone after the same number of cycles increased at a relatively higher rate, and there was a transition of failure mode from brittle to ductile.
MicroRNA miR-99b-5p Targets mTOR/AR axis, Induces Autophagy, and Inhibits Prostate Cancer Cell Proliferation
Authors: Niture Suryakant , Tricoli Lucas , Qi Qi , Gadi Sashi , Hayes Kala , Kumar Deepak 
Published: October 2021

Abstract
BackgroundMicroRNAs (miRNAs) are the small non-coding regulatory RNA molecules involved in gene regulation via base-pairing with complementary sequences in mRNAs. The dysregulation of specific miRNAs, such as miR-99b-5p (miR-99b), is associated with prostate cancer (PCa) progression. However, the mechanistic role of miR-99b in PCa remains to be determined. In this study, we aimed to investigate the functional and clinical significance of miR-99b in PCa.MethodsThe expression of miR-99b and its downstream targets mTOR/AR in the PCa samples were analyzed by RT/qPCR. The effects of miR-99b overexpression/inhibition on PCa cell survival/proliferation, spheroid formation, and cell migration were examined by specific assays. Luciferase reporter assays were performed to determine the binding of miR-99b to 3’ UTR of the mTOR gene. The effect of miR-99b on the expression of mTOR, AR, and PSA proteins, as well as on AKT/mTOR signaling, autophagy, and neuroendocrine differentiation markers, was analyzed by western blotting. The expression of miR-99b, mTOR, AR, PSA in AR-negative PC3 and AR-positive LNCaP cells was analyzed by RT/qPCR. The effect of miR-99b on global gene expression in PC3 cells was analyzed by RNA-seq. ResultsThe expression of miR-99b was downregulated in tumor samples from PCa patients, whereas the expression of mTOR and AR was upregulated. In PCa cell lines, overexpression of miR-99b inhibited cell proliferation and cell colony/spheroid formation; induced apoptosis, and increased sensitivity towards docetaxel (DTX). In contrast, inhibition of miR-99b by miR-99b inhibitor resulted in increased cell growth in PCa cells. Mechanistically, miR-99b inhibited the expression of the mammalian target of the rapamycin (mTOR) gene by binding to its 3’ untranslated region (UTR) and induced autophagy. Furthermore, miR-99b inhibited androgen receptor (AR) activity in LNCaP cells and induced apoptosis. Activation of AR signaling by dihydrotestosterone (DHT) downregulated miR-99b expression and promoted cell PCa cell growth/survival, whereas inactivation of mTOR by rapamycin or AR by enzalutamide deceased miR-99b mediated PCa cell growth. ConclusionsOur data suggests that miR-99b functions as a tumor suppressor by targeting the mTOR/AR axis in PCa cells, implicating miR-99b as a novel biomarker and therapeutic target for PCa management.
WITHDRAWN: Antimicrobial Resistance Pattern of Bacterial Meningitis Among Patients in Quetta, Pakistan
Authors: Ali Syeda Ayesha , Taj Muhammad Kamran , Ali Syeda Hafsa 
Published: October 2021

Abstract
Bacterial meningitis (BM) is lethal infectious disease that persists as substantial cause of morbidity and mortality. The antimicrobial drug resistances in BM pathogens possess a major threat in the community, while escalating challenges for clinicians. We for the first time elucidate incidence rate of BM and its drug resistance among the population of Quetta, Balochistan. A cross-sectional study was conducted (form January 2018 to March 2021) among meningitis patients admitted at Government Hospitals in Quetta. The cerebrospinal fluid (CSF) specimen was collected and processed for microbiological and cytological analysis. Bacterial isolates were identified and confirmed using phylogenetic analysis of 16S rRNA gene. We found 35.9% (321/894) confirmed cases of BM among the population of Quetta, Balochistan. The identified bacterial isolates comprised of Streptococcus pneumonia 14.7% (130/894), Staphylococcus aureus 6.9% (61/894), Neisseria meningitidis 5.7% (51/894). Haemophilus influenza 2.5% (22/894), Escherichia coli 4.5% (40/894), and Klebsiella pneumoniae 1.9% (17/894). A surge in male patients 20.8% (186/894) was identified as compare to female patients 15.1% (135/894). Extreme age groups such as Infants (age range: 1month- 1year) and adults (age range: 61years- 99years) with low immunity were critically affected with BM. Clinical parameters such as abnormal CSF appearance, pH, high WBCs in BM patients with endocarditis as underlying disease were significantly at elevated risk of fatal outcome. 16S rRNA gene phylogenetic analysis confirmed evolutionary similarity of isolated strains with prevailing pathogenic strains in Asia. Furthermore, age was identified as significant risk factors for clinical outcomes. Majority of the identified BM patients belonged to rural areas with limited healthcare facilities and paramedics’ staff. High fatality rate demonstrates increased antibiotic resistance among BM isolates, thereby stimulating its devastation among underdeveloped region. Timely detection and intensive treatment of BM may improve critical outcomes in patients
A Novel Systems Model to Simulate the Dynamics for the Analytical Study of the Proliferation of COVID-19
Authors: Welling Arpita , Patel Abhilasha , Kulkarni Padmaj , Vaidya Vinay G. 
Published: October 2021

Abstract
In this paper, we present a systems model for COVID-19 called ‘Multilevel Integrated Model with a Novel Systems Approach’ or MIMANSA for short. This model goes to the individual patient level and mimics small steps in the process of virus spread. Despite many models simulating the growth of COVID-19 cases, it is rare to see a comprehensive model that takes into account the transmissibility of variants, the prevalence of multiple variants, growth of the variants, percentage of vaccinated population, exposure rate, infection rate, silent carrier rate, secondary infection rate, mask usage, and people mobility all in one model.We begin by categorizing the in-person social interactions of an individual into three areas: household, workplace, and public places. With each interaction, the virus spreads from an infectiousperson to a healthy individual. We build the model, one level at a time, covering daily person-to-person interactions. Further, MIMANSA forms a new layer of network for every new day. These layers form a part of the virus proliferation network.MIMANSA models the virus incubation period using a Weibull distribution. Once the network starts building, the virus growth can be curtailed only through increased vaccinations or through non-pharmaceutical interventions such as mask usage, reduced mobility, and/or quarantine.MIMANSA takes the mobility data, mask usage data, variant prevalence data, and vaccination data as inputs. Despite the model being intricate, it uses only 5 parameters for training. Once the model is trained, it can be slightly adjusted by the daily environmental variable. This variable corrects for day to events as well as varying environmental conditions in a given location.We present the results of the training and validation for the USA, California, and the UK. It is seen that during the validation stage, the model accuracy is within 2%. Further, projections are made for about 3 weeks. In the end, we have presented the results of a study on the effect of vaccination on the number of COVID cases in the USA. It shows how MIMANSA can be used for studying the impact of multiple scenarios. Additionally, the model is not only useful for making predictions in the number of cases but also useful as an educational aid for explaining the proliferation network of the virus in real life. Although MIMANSA is originally developed for the SARS-CoV-2, it can be modified to study the spread of any other virus, and in any region.
PSICOLOGÍA POSITIVA Y EDUCACIÓN FAMILIAR: UNA PROPUESTA DE COMPLEMENTARIEDAD
Authors: Esponda Jones Gabriela 
Published: October 2021

La psicología positiva es una nueva y pujante rama de la psicología tradicional que estudia los estados emocionales positivos de la conducta humana con la finalidad de llevar a cabo una labor preventiva de los padecimientos de orden mental.
Este escrito pretende acercar esta rama de las ciencias de la conducta a la pedagogía —a través de la educación familiar—, mediante la presentación de dos de sus importantes áreas de estudio: el optimismo y la sabiduría. También intenta generar estrategias educativas que faciliten su implementación en la vida familiar. Estos dos aspectos, como todos los que estudia la psicología positiva, son educables. Los elementos que construyen estas actitudes positivas son el material básico para el aprendizaje de razonamientos y hábitos saludables que se traduzcan en una mejor calidad de vida y en la disminución de los índices de disfuncionalidad mental.
COMPETENCIAS DIRECTIVAS DEL DOCENTE UNIVERSITARIO
Authors: Villalobos Torres Elvia Marveya , Parés Gutiérrez Isabel 
Published: October 2021

En una institución educativa, las competencias directivas del docente universitario se contituyen, ante todo, por la integración y coordinación de las competencias personales; éstas representan una integración y una coordinación del savoir-faire, conocimientos y cualidades personales.
La visión del docente debe implicar su papel como directivo del grupo de estudiantes a su cargo. De él depende, en gran medida, la formación de jóvenes para que, con base en un perfil de egreso de las diversas áreas del conocimiento de las instituciones de educación superior (IES), sean personas competentes que colaboren en la mejora social. Sin esta visión del docente-líder, docente-director, difícilmente se alcanzarán los resultados que requiere la educación superior mexicana para continuar con el perfeccionamiento de cada persona y de la sociedad.
UNA CARACTERIZACIÓN DEL HUMOR VIOLENTO EN LA ENSEÑANZA UNIVERSITARIA
Authors: Fernández Poncela Anna María 
Published: October 2021

El objetivo general de este texto es revisar el humor violento a través de teorías y funciones del humor, en primer lugar. En segundo lugar, y en concreto, realizar una caracterización de los tipos o las formas, y las expresiones o los modos, en su práctica cotidiana en general, y especialmente en la enseñanza aprendizaje.
Esto se realizó con la participación de jóvenes universitarios que expresaron opiniones y relataron experiencias, a través de una encuesta de grupos de enfoque y de narraciones. Como principal resultado es posible afirmar la vigencia del humor violento e incluso su magnitud en nuestros días, en la vida y en el espacio educativo.
Response to Fluvoxamine in the Obsessive-Compulsive Disorder Patients: Bayesian Ordinal Quantile Regression
Authors: Safiloo Samad , Mehrabi Yadollah , Asadi Sareh , Khodakarim Soheila 
Published: October 2021

Background:Obsessive-Compulsive Disorder (OCD) is a chronic neuropsychiatric disorder associated with unpleasant thoughts or mental images, making the patient repeat physical or mental behaviors to relieve discomfort. 40-60% of patients do not respond to Serotonin Reuptake Inhibitors, including fluvoxamine therapy.Introduction:The aim of the study is to identify the predictors of fluvoxamine therapy in OCD patients by Bayesian Ordinal Quantile Regression Model.Methods:This study was performed on 109 patients with OCD. Three methods, including Bayesian ordinal quantile, probit, and logistic regression models, were applied to identify predictors of response to fluvoxamine. The accuracy and weighted kappa were used to evaluate these models.Results:Our result showed that rs3780413 (mean=-0.69, sd=0.39) and cleaning dimension (mean=-0.61, sd=0.20) had reverse effects on response to fluvoxamine therapy in Bayesian ordinal probit and logistic regression models. In the 75thquantile regression model, marital status (mean=1.62, sd=0.47) and family history (mean=1.33, sd=0.61) had a direct effect, and cleaning (mean=-1.10, sd=0.37) and somatic (mean=-0.58, sd=0.27) dimensions had reverse effects on response to fluvoxamine therapy.Conclusion:Response to fluvoxamine is a multifactorial problem and can be different in the levels of socio-demographic, genetic, and clinical predictors. Marital status, familial history, cleaning, and somatic dimensions are associated with response to fluvoxamine therapy.
Radioprotective and Anticancer Efficacies of Ganoderma Lucidum in a
Mouse Tumor Model
Authors: Gu Yeun-Hwa , Yamashita Takenori , Kang Ki-Mun , Inoue Tota 
Published: October 2021

Background:
Radiation dose is limited by deleterious nontarget effects, such as immunosuppression, necessitating the development of safe radioprotectants. In this study, we examined the radioprotective and anticancer efficacies of the traditional medicinal mushroom Ganoderma lucidum (GL) in a mouse xenograft tumor model.

Methods:
An aqueous extract was prepared from raw GL and administered by intraperitoneal injection. For the assessment of antitumor efficacy, ICR mice were inoculated with Sarcoma 180 cells and tumor growth (size and weight) compared among control (no treatment), GL alone, radiation alone, and GL plus radiation groups. For the assessment of the protection of the immune system, ICR mice received whole-body irradiation at 2 Gy for 2 weeks or longer with or without intraperitoneal GL administration, and changes in leukocyte, lymphocyte, and monocyte counts were measured. To examine the antioxidant efficacy of GL, ICR mice received whole-body radiation at 2 Gy with or without GL and plasma antioxidant activity measured by the luminol method.

Results:
Finally, the effects of GL on T helper (CD4-positive) and natural killer (CD8-positive) cell numbers were measured in C57BL mice by flow cytometry. GL administration alone suppressed tumor growth and the tumor-associated increase in lymphocyte and monocyte numbers. In addition, GL enhanced plasma antioxidant activity as well as both helper and natural killer T cell numbers in the presence and absence of irradiation.

Conclusion:
Collectively, these results demonstrate the antitumor and radioprotective efficacies of GL, which are likely mediated by protection against oxidative stress and preservation of immune cell populations.