bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence
Authors: Li Yanfei , Duan Ranran , Gong Zhe , Jing Lijun , Zhang Tian , Zhang Yong , Jia Yanjie 
Published: November 2021

Background: Alcohol dependence, a global public health problem, leads to structural and functional damage in the brain. Alcohol dependence patients present complex and varied clinical manifestations and live with general complaints existing in contemporary society, making most people with alcohol dependence hard to identify. Therefore, it is important to find potential biomarkers for the diagnosis and evaluation of alcohol dependence. In the study, we explored potential biomarkers for the diagnosis and monitoring of diseases and evaluated brain structural changes in alcohol dependence patients.Methods: Enzyme-linked immunosorbent assay (ELSA) was employed to detect the expression of serum nucleotide-binding oligomerization domain containing 3 (NLRP3) and single-molecule array (Simoa) assay was used to detect the expression of serum neurofilament light (NfL) in 50 alcohol dependence patients and 50 controls with no drinking history. Alcohol consumption was measured by standard drinks. Neuropsychological assessments, including the Montreal cognitive assessment (MoCA), Pittsburgh sleep quality index (PSQI), generalized anxiety disorder (GAD-7), and patient health questionnaire-9 (PHQ-9), were conducted to evaluate cognitive function and psychological state. The degree of white matter lesions (WMLs) was rated using the Fazekas scale based on magnetic resonance imaging analysis. White matter structure was quantified using the voxel-based morphometry method. The correlations between NLRP3 levels, NfL levels, neuropsychological dysfunction, the degree of WMLs, and white matter volume (WMV) were analyzed in alcohol dependence patients.Results: Serum NLRP3 and NfL levels were higher in the alcohol dependence group. NLRP3 levels were irrelevant to monthly alcohol assumption as well as to the MoCA, PSQI, GAD-7, PHQ-9, and Fazekas scale scores and WMV. NfL levels were positively correlated with the PSQI and PHQ-9 scores as well as the degree of WMLs and negatively correlated with the MoCA scores and WMV. No associations were evident between NfL and monthly alcohol assumption and GAD-7 scores in the alcohol dependence group.Conclusion: This study supports the potential value of serum NfL as a non-invasive biomarker in alcohol dependence. The association with neuropsychological dysfunction and degree of WMLs has implications to use NfL as a promising biomarker to assess the severity of brain damage as well as the progression and prognosis of alcohol dependence.
Comparison of Delay in Tuberculosis Diagnosis Between Migrants and Local Residents in an Eastern County of China: An Analysis of the Electronic Data Between 2015 and 2019
Authors: Xiao Wenhui , Chen Bin , Huang Dajiang , Chan Olivia , Wei Xiaolin , Zhou Lin , Zou Guanyang 
Published: November 2021

Introduction: China continues to rank among one of the countries with the highest number of tuberculosis (TB) cases globally. Migrants are a particularly at-risk subgroup for TB and pose a challenge for case management in contemporary China. The early diagnosis and treatment of patients with TB are pivotal for effective TB control. This study investigates the delay in the TB diagnosis of migrants as compared with residents, to provide an evidence base for improved case detection and the better management of migrant patients with TB.Materials and Methods: The data was collected from the Tuberculosis Information Management System (TBIMS) (2015–2019) in an eastern county of China. The total diagnostic delay, consisting of patient delay and health system delay, is defined as the interval between the onset of TB symptoms and the confirmation of TB diagnosis in the designated TB hospital. The comparison of the delay in the TB diagnosis between migrants and residents was conducted using a Mann-Whitney U-test and chi-square test. The difference in the delay curves between these two groups was examined using a log-rank test.Results: Of 2,487 patients with TB, 539 (22%) were migrants. The migrants tended to be younger, presented with less severe conditions, received an initial diagnosis at prefectural and above-level hospitals. Compared with the local patients with TB, the migrant patients with TB had a longer median total diagnostic delay (30 vs. 9, P = 0.000) and a higher proportion of patients with this delay &gt;28 days (52 vs. 13%, P = 0.000). Similarly, the migrant patients with TB also had a longer median patient delay (13 vs. 9, P = 0.000) and a higher proportion of patients with this delay &gt;14 days (47 vs. 30%, P = 0.000), longer median health system delay (9 vs. 0, P = 0.000), and a higher proportion of patients with this delay &gt;14 days (42 vs. 0.5%, P = 0.000) than the local patients with TB. The survival curves of delay showed that the longer the time interval was, the more likely the migrant patients with TB were to be diagnosed (P &lt; 0.05).Conclusions: Diagnosis is significantly delayed among migrant patients with TB. Our study highlights the importance of early screening and diagnosis for TB especially among migrants, to improve access and ensure better management for all patients with TB.
Effects of Preoperative Carbohydrate Intake on Inflammatory Markers and Clinical Outcomes in Elderly Patients Undergoing Radical Prostatectomy: A Single-Centre, Double-Blind Randomised Controlled Trial
Authors: Hu Zhen , Liu Ji , Wang Fen 
Published: November 2021

Background: This study aimed to analyse the effects of carbohydrate (CHO) intake on inflammatory markers, comfort, and clinical outcomes in elderly patients undergoing open radical prostatectomy.Methods: Patients aged ≥65 years who underwent open radical prostatectomy were randomly divided into CHO, drinking water, and fasting groups. A total of 90 patients were enrolled in this study (CHO group, n = 28; placebo group, n = 30 and fasting group, n = 32). Patients in the CHO group were given 800 and 400 ml of carbohydrates 8 and 2–3 h before surgery, respectively. Patients in the placebo group were given 800 and 400 ml of water 8 and 2–3 h before surgery, respectively. Patients in the fasting group did not consume any liquids. The main result is levels of inflammation markers. Secondary results included cellular immunity, comfort, body weight, grip index, and clinical results.Results: Compared with the fasting group, the CHO group exhibited a decrease in interleukin 6 (IL-6) levels on days 1 and 7 (75.47 and 7.06 pg/mL, respectively), IL-8 levels on day 1 (274.61 pg/mL) and tumour necrosis factor (TNF) levels on days 1, 3, and 7 (11.16, 9.55, and 9.67 pg/mL, respectively). The placebo group exhibited a decrease in IL-8 (390.26 pg/mL) and TNF levels (13.99 pg/mL) on day 1. Compared with the placebo group, the CHO group exhibited a decrease in IL-6 levels on day 1 and TNF levels on day 3. In the CHO and placebo groups, the thirst and hunger scores decreased on the morning of surgery.Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF. CHO and water can also reduce thirst and hunger scores. Therefore, we recommend that patients without contraindications should be given 200–400 ml of fluid 2–3 h before surgery, preferably CHO.Clinical Trial Registration:http://www.chictr.org.cn/edit.aspx?pid=21783&amp;htm=4; ChiCTR-INR-17012867.
Collateral Effects and Mortality of Kidney Transplant Recipients during the COVID-19 Pandemic
Authors: Schmidt-Lauber Christian , Günster Christian , Huber Tobias B. , Spoden Melissa , Grahammer Florian 
Published: November 2021

Key Points

Despite significant collateral effects on kidney transplant recipients during the early COVID-19 pandemic, mortality remained unchanged.Considerable temporary reductions in admissions are safe, whereas reducing immunosuppression results in increased allograft rejection risk.

Background
Collateral effects and consequences of the coronavirus disease 19 (COVID-19) pandemic on kidney transplant recipients remain widely unknown.

Methods
This retrospective cohort study examined changes in admission rates, incidences of diseases leading to hospitalization, in-patient procedures, and maintenance medication in long-term kidney transplant recipients with functioning graft during the early COVID-19 pandemic in Germany. Data were derived from a nationwide health insurance database. Analysis was performed from March 15 to September 30 and compared the years 2019 and 2020. Effects on mortality and adverse allograft events were compared with COVID-19-attributed effects.

Results
A total of 7725 patients were included in the final analysis. Admissions declined in 2020 by 17%, with the main dip during a 3-month lockdown (–31%) but without a subsequent rebound. Incidences for hospitalization did not increase for any investigated disease entities, whereas decreasing trends were noted for non-COVID-19 pulmonary and urogenital infections (incidence rate ratio 0.8, 95% CI, 0.62 to 1.03, and 0.82, 95% CI, 0.65 to 1.04, respectively). Non-COVID-19 hospital stays were 0.6 days shorter (P=0.03) and not complicated by increased dialysis, ventilation, or intensive care treatment rates. In-hospital and 90-day mortality remained stable. Incidences of severe COVID-19 requiring hospitalization was 0.09 per 1000 patient-days, and in-hospital mortality was 9%. A third (31%) of patients with calcineurin-inhibitor medication and without being hospitalized for COVID-19 reduced doses by at least 25%, which was associated with an increased allograft rejection risk (adjusted hazard ratio 1.29, 95% CI, 1.02 to 1.63). COVID-19 caused 17% of all deaths but had no significant association with allograft rejections. All-cause mortality remained stable (incidence rate ratio 1.15, 95% CI, 0.91 to 1.46), also when restricting analysis to patients with no or outpatient-treated COVID-19 (0.97, 95% CI, 0.76 to 1.25).

Conclusion
Despite significant collateral effects, mortality remained unchanged during the early COVID-19 pandemic. Considerable temporary reductions in admissions are safe, whereas reducing immunosuppression results in increased allograft rejection risk.
Model SEIRS Penyebaran Penyakit Tuberkulosis di Kota Makassar
Authors: Syam Rahmat , Side Syafruddin , Said Citra Suci 
Published: November 2021

Abstrak. Penelitian ini bertujuan untuk membangun model penyebaran penyakit tuberkulosis tipe SEIRS (Susceptible- Exposed- Infected- Recovered- Susceptible) dengan menambahkan asumsi bahwa manusia yang pulih dapat rentan kembali terkena tuberkulosis. Model ini dibagi menjadi empat kelas yaitu, rentan, terinfeksi tapi belum aktif, terinfeksi, dan sembuh. Data yang digunakan adalah data jumlah penderita penyakit tuberkulosis dari Dinas Kesehatan Kota Makassar tahun 2017. Model matematika tipe SEIRS digunakan untuk menentukan titik equilibrium. Berdasarkan hasil simulasi model SEIRS diperoleh bilangan reproduksi dasar ( ) sebesar 0,312 berarti bahwa seseorang yang terinfeksi penyakit tuberkulosis tidak menyebabkan orang lain terkena penyakit tuberkulosis di wilayah Kota Makassar.Kata Kunci: Titik Equilibrium, Bilangan Reproduksi Dasar, Tuberkulosis, Model SEIRS, Pemodelan.Abstract. This research aims to model of tuberculosis type SEIRS (Susceptible-Exposed-Infected-Recovery-Susceptible) by adding assumption that human that has been recovered can be suspected again by Tuberculosis. This model can be divided to four classes, those are suspected, exposed, infected, and recovered. The data that used is data on the number of tuberculosis sufferer from Health Department in Makassar City 2017. Mathematicsl model of SEIRS type is used to determine the equilibrium point. According to the simulation results of SEIRS model, obtained the base reproduction number ( ) is 0.312 means that people who infected by tuberculosis does not causes other people get tuberculosis in Makassat city.Keywords: Equilibrium Point, Basic Reproduction Numbers, Tuberculosis, SEIRS Model, modeling.
Bilangan Kromatik Pewarnaan Titik pada Graf Dual dari Graf Roda
Authors: Abdy Muhammad , Syam Rahmat , Tina T. 
Published: November 2021

Penelitian ini bertujuan mengkonstruksi graf dual dari graf roda (Wn*) dan menentukan bilangan kromatik graf dual dari graf roda (Wn*). Penelitian ini dimulai dari menggambarkan beberapa graf roda dari ke , kemudian membangun graf dual dari graf roda dengan memanfaatkan graf-graf dari ke , kemudian memberikan warna pada titik-titik dari graf dualnya dengan menentukan bilangan kromatiknya. Diperoleh hasil bahwa Graf roda merupakan graf self-dual karena isomorfik dengan graf dualnya yaitu . Pewarnaan titik diperoleh dengan menentukan bilangan kromatik graf dual dari graf roda, menentukan pola dari bilangan kromatik, dan memberikan warna. Berdasarkan hasil penelitian, diperoleh bilangan kromatik pewarnaan titik pada graf dual dari graf roda yakni Kata Kunci: Pewarnaan Titik, Bilangan Kromatik, Graf Dual dan Graf Roda.This research aims to construct a dual graph from a wheel graph (Wn*) and determine the dual graph chromatic number of the wheel graph (Wn*). This research starts from describing some wheel graph from to , then construct a dual graph from a wheel graph from to , then gives color to the vertices of the dual graph by determining the chromatic number. The result showed that the wheel graph is a self-dual graph because it is isomorphic with its dual graph, namely . The vertex coloring is obtained by determining the chromatic number of the dual graph of the wheel graph, determining the pattern of the chromatic number and giving the color. Based on the research results, the chromatic number of vertex coloring on dual graph of a wheel graph is: Keywords: Vertex Coloring, Chromatic Number, Dual Graph and Wheel Graph.
ПРОБЛЕМА ЕМОЦІЙНОЇ СТІЙКОСТІ ВИХОВАТЕЛЯ В СПЕЦІАЛЬНИХ ЗАКЛАДАХ ДОШКІЛЬНОЇ ОСВІТИ
Authors: Войтович Оксана 
Published: November 2021

Анотація. У статті аналізується проблема формування професійних якостей вихователя закладів спеціальної дошкільної освіти, зокрема особливості їх розвитку в процесі підготовки студентів до професійної діяльності. Здійснюється аналіз психолого-педагогічних досліджень проблеми. Подається визначення поняття емоційної стійкості педагога, аналізуються її складові та особливості їх формування; поняття емоційного вигорання та саморегуляції вихователя, а також симптоми порушень емоційної саморегуляції, наводяться чинники, які їх детермінують (негативний соціально-психологічний клімат, взаємини в колективі і з керівництвом, ставлення до об’єкта праці, наявність напруженості й конфліктів у професійному середовищі). Розглядаються засоби формування емоційної стійкості та саморегуляції в процесі підготовки здобувачів до професійної діяльності та профілактики порушень (семінари, практичні заняття з елементами тренінгу, спрямовані на ознайомлення з особливостями емоційної стійкості та професійної саморегуляції, феноменом професійного та емоційного вигоряння). Стаття презентує результати дослідження з даної проблеми, а саме визначення рівнів емоційної стійкості та саморегуляції здобувачів вищої освіти напряму спеціальна освіта та фахівців, а також напрями роботи з розвитку емоційної стійкості майбутніх вихователів закладів спеціальної освіти. Методи корекції, представлені в статті, спрямовані на підвищення рівня емоційної грамотності та самооцінки, рівня емпатії, впевненості в собі, формування мотивів домагань здобувачів.
MENJADI GURU SEKOLAH DASAR YANG INOVATIF DI ERA REVOLUSI INDUSTRI 4.0
Authors: Teguh Teguh 
Published: November 2021

AbstractIn the era of an industrial revolution of 4.0 education integrated Cyber technology into learning to prepare students for digital challenges. Students need to have the competence to be able to utilize information and communication technology. A diverse range of students with varying degrees of digital divide also demand teachers to be creative and innovative in their learning. Innovative learning by resting on the four principles of learning is student-centered, collaborative, context-and school-integrated with the community. Keywords: Innovative elementary school teacher, Industrial Revolution 4.0 AbstrakPada era revolusi industri 4.0 pendidikan mengintegrasikan teknologi siber ke dalam pembelajaran demi mempersiapkan siswa untuk menghadapi tantangan digital. Siswa perlu memiliki kompetensi untuk dapat memanfaatkan teknologi informasi dan komunikasi. Beragam kemampuan siswa dengan tingkat kesenjangan digital yang beragam pula menuntut guru untuk kreatif dan inovatif dalam pembelajaran. Pembelajaran yang inovatif dengan bertumpu pada empat prinsip pembelajaran yaitu berpusat pada siswa, bersifat kolaborasi, memiliki konteks, dan sekolah terintegrasi dengan masyarakat. Kata kunci: Guru SD Inovatif, Revolusi Industri 4.0
IMPLEMENTASI NILAI KARAKTER SISWA SD NEGERI 62 PALEMBANG MELALUI PENERAPAN MEDIA PEMBELAJARAN IPS SD BERBASIS EDUTAINMENT
Authors: Harini Bunda , Usman Nuraini 
Published: November 2021

This study aims to describe the implementation of character values for students of SD Negeri 62 Palembang through the application of edutainment-based social studies learning media. This research uses a qualitative approach with descriptive methods. The subjects of this study were second grade students of SD Negeri 62 Palembang. The data collection techniques used in this study were observation and questionnaires and documentation. Edutainment-based learning media used is a game of guessing style. The character values observed when students played the style guess were cooperation, self-confidence, and discipline. Based on the results of observations made, this game is less effective if it is done on grade II students who are included in the low class, because when playing, many students still lack self-confidence. Therefore, it should be applied to high grade students. Keywords: Implementation, Character Value, Edutainment-Based Learning Media
Améliorer la prévision de température en montagne par des descentes d'échelle
Authors: Arnould Gabriel , Dombrowski-Etchevers Ingrid , Gouttevin Isabelle , Seity Yann 
Published: November 2021

En montagne, la prévision du temps et d'aléas aussi dangereux et localisés que les avalanches requiert une modélisation de l'atmosphère à haute résolution spatiale. Palliant des simulations coûteuses, des méthodes de descente d'échelle ont été appliquées pour produire des champs météorologiques à 500 m de résolution, sur les massifs alpins, à partir des prévisions issues du modèle Arome à 1,3 km. L'évaluation s'est concentrée sur la température à 2 mètres, paramètre météorologique clé pour la physique du manteau neigeux. Une descente d'échelle exploite un profil thermique environnemental. Sa pertinence est démontrée dans certaines configurations météorologiques, mais les erreurs intrinsèques au modèle Arome contraignent son potentiel.
In mountain areas, a numerical model with high spatial resolution is necessary to forecast the local meteorological conditions and the natural hazard such as avalanches. To limit time-consuming computations, downscaling methods were used to produce meteorological fields within a grid spacing of 500 m in the Alps from the Météo-France 1.3 km resolution forecast model (Arome). The evaluation focuses on the 2 meters temperature which is a key variable in snowpack changes. One method employs a correction based on a local vertical temperature lapse rate. Its impact is quite positive in some atmospheric conditions but remains limited by the Arome bias.
What do digital tools add to classical tools for sociocommunicative and adaptive skills in children with Autism Spectrum Disorder?
Authors: Trémaud Maëla , Aguiar Yuska Paola , Pavani Jean-Baptiste , Gepner Bruno , Tardif Carole 
Published: November 2021

Contexte. On sait peu de choses sur l’effet respectif de l’utilisation des outils numériques vs des outils classiques sur les apprentissages d’enfants avec trouble du spectre de l’autisme et trouble du développement intellectuel associé (TSA TDI). Méthode. Pour travailler les compétences en socialisation, autonomie et communication, un groupe cible de 11 enfants (âge moyen : 9 ans 8 mois) utilisent une tablette tactile dotée d’applications (AMIKEO, Auticiel®) et un groupe de comparaison de 11 enfants (âge moyen : 9 ans 2 mois) utilisent des supports classiques recommandés par les evidence-based practices (EBP). Leurs compétences sont évaluées au début de l’étude et au terme d’une année de travail à partir de leurs scores aux items de la VINELAND-II. Résultats. Ces scores augmentent significativement chez les enfants du groupe cible, mais pas chez ceux du groupe de comparaison. Conclusion. Les outils numériques facilitent plus que les outils classiques les apprentissages des compétences adaptatives et sociocommunicatives des enfants avec TSA et TDI associé.
Reducing the split-attention effect of subtitles during video learning: might the use of occasional keywords be an effective solution?
Authors: Cojean Salomé , Martin Nicolas 
Published: November 2021

Les vidéos pédagogiques présentent des bénéfices (e.g., animations, multi-modalité) mais également des contraintes à prendre en compte. Par exemple, en présence de sous-titres, un effet d’attention divisée peut apparaître entre l’audio, le texte écrit et les illustrations. Une solution serait de présenter des mots-clés à la place des sous-titres afin d’éviter une redondance inutile et de guider l’apprenant à sélectionner l’information pertinente. Dans cette étude, 96 participants ont appris une vidéo de 12 minutes avec ou sans sous-titres, et avec ou sans information mise en saillance (i.e., mots-clés). Les résultats n’ont montré aucun effet des sous-titres, mais les mots-clés ont un effet négatif sur la mémorisation, la compréhension et le temps d’apprentissage. Ces résultats sont discutés en termes de stratégies mises en place. Les apprenants n’auraient pas utilisé les mots-clés pour les guider dans la sélection de l’information, mais les auraient considérés comme remplaçant ce processus, surestimant ainsi leur apprentissage.
Questionnaire MiFID et participation sur les marchés actions
Authors: Broihanne Marie-Hélène , Orkut Hava 
Published: November 2021

La Directive sur les marchés d’instruments financiers (MiFID) a pour objectif de protéger les investisseurs européens. Elle impose aux prestataires de services d’investissement de collecter des informations sur leurs clients via un questionnaire. Dans cet article, nous combinons les réponses au questionnaire MiFID et les données bancaires d’environ 50 000 clients d’une grande banque commerciale en France. Nous montrons que les indicateurs MiFID, c’est-à-dire la littératie financière subjective, la tolérance au risque et les attitudes face aux pertes auto-évaluées, affectent significativement la participation sur les marchés actions tout en contrôlant divers déterminants classiques, tels que les caractéristiques sociodémographiques et la richesse nette. Nos résultats sont robustes à une approche par variable instrumentale pour la littératie financière. Classification JEL : G02, G11, G28