bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family Talk versus usual services in improving child and family psychosocial functioning in families with parental mental illness (PRIMERA—Promoting Research and Innovation in Mental hEalth seRvices for fAmilies and children): study protocol for a randomised controlled trial
Authors: Furlong Mairead , McGilloway Sinead , Mulligan Christine , McGuinness Colm , Whelan Nuala 
Published: April 2021

Abstract
Background
Parental mental illness is common and can lead to dependent children incurring a high risk of developing mental disorders, physical illness, and impaired educational and occupational outcomes. Family Talk is one of the better known interventions designed to prevent the intergenerational transmission of mental illness. However, its evidence base is small, with few robust independent randomised controlled trials, and no associated process or cost evaluations. The PRIMERA (Promoting Research and Innovation in Mental hEalth seRvices for fAmilies and children) research programme involves a mixed method evaluation of Family Talk which is being delivered in mental health settings in Ireland to improve child and family psychosocial functioning in families with parental mental illness.

Methods
The study comprises a multi-centre, randomised controlled trial (RCT), with nested economic and process evaluations, to assess the clinical and cost-effectiveness and implementation mechanisms of Family Talk compared to usual services. The study is being conducted in 15 adult and child mental health settings in Ireland. Families with a parent with mental illness, and children aged 5–18 years (n = 144 families) will be randomised to either the 7-session Family Talk programme (n = 96) or to standard care (n = 48) using a 2:1 allocation ratio. The primary outcomes are child psychosocial functioning and family functioning. Secondary outcomes are as follows: understanding and experience of parental mental illness, parental mental health, child and parental resilience, partner wellbeing and service utilisation. Blind assessments will take place at pre-intervention and at 6- and 12-month follow-up.

Discussion
Given the prevalence and burden of intergenerational mental illness, it is imperative that prevention through evidence-based interventions becomes a public health priority. The current study will provide an important contribution to the international evidence base for Family Talk whilst also helping to identify key implementation lessons in the scaling up of Family Talk, and other similar interventions, within routine mental health settings.

Trial registration
ISRCTN Registry, ISRCTN13365858. Registered 5th February 2019.
The development of an effective synthetic route of rilpivirine
Authors: Zhang Tao , Yang Jiapei , Zhou Zhongxia , Fu Zhipeng , Cherukupalli Srinivasulu , Kang Dongwei , Zhan Peng , Liu Xinyong 
Published: April 2021

Abstract
Background
Rilpivirine (RPV) was approved by the U.S. FDA (Food and Drug Administration) in 2011 to treat individuals infected with human immunodeficiency virus 1 (HIV-1). Significantly, rilpivirine is three fold more potent than etravirine. Once-daily, it is used with a low oral dose (25 mg/tablet), decreasing the drug administration and bringing a better choice to the patients. However, there are many shortcomings in the existing synthesis route of RPV, such as the high cost, prolonged reaction time and low yield (18.5%).

Results
This article describes our efforts to develop an efficient and practical microwave-promoted method to synthesize rilpivirine using less toxic organic reagents and low boiling solvents. The last step's reaction time decreased from 69 h to 90 min through this optimized synthetic procedure, and the overall yield improved from 18.5 to 21%. In addition, the yield of intermediate 3 increased from 52 to 62% compared to the original patent.

Conclusion
Overall, through a series of process optimization, we have developed a practical synthesis method of rilpivirine, which is easy to scale with higher yield and shorter reaction time.
Falls and fear of falling among Israeli community-dwelling older people: a cross-sectional national survey
Authors: Frankenthal Dvora , Saban Mor , Karolinsky Dolev , Lutski Miri , Sternberg Shelley , Rasooly Iris , Laxer Irit , Zucker Inbar 
Published: April 2021

Abstract
Background
Falls and fear of falling are a major problem for older people and a leading cause of functional decline and institutionalization. There is limited data on the prevalence of falls in a 12-month period among Israeli older adults. Our main objective was to evaluate the prevalence of falls among Israeli community-dwelling older people aged ≥65 years and to identify factors associated with falls and fear of falling.

Methods
A national cross-sectional interview survey was conducted between February 2018 and April 2019 by the Israeli Center for Disease Control. The prevalence of falls was assessed by asking participants about falling within the 12 months prior to the survey. Fear of falling was assessed by asking participants about the fear of future falls. Multivariate analysis was used to identify factors associated with falls and with fear of falling.

Results
From 5281 households that were eligible for inclusion in this study, 3242 participants (61.4%) completed the survey. Falling at least once in the past year was reported by 23.8% of the respondents and fear of falling by 48.2%. The majority of the participants (91.1%) reported that they had never received any instruction about fall prevention from their medical care provider. In the multivariate analysis, falls and fear of falling were each a risk factor for the other; and were also significantly associated with female gender, major functional difficulties, the use of walking aids, cardiac disease, diabetes mellitus and psychotropic medications.

Conclusion
The prevalence of falls and fear of falling among Israeli community-dwelling older people is comparable to the rates published in other countries. Efforts should be made to increase awareness about falls and their health consequences among older people. The development of specific interventions to target those at higher risk for falls and fear of falling is strongly recommended.
Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
Authors: Seifi Najmeh , Jafarzadeh Esfahani Ali , Sedaghat Alireza , Rezvani Reza , Khadem-Rezaiyan Majid , Nematy Mohsen , Safarian Mohammad 
Published: April 2021

Abstract
Purpose
The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally fed critically ill adult patients.

Methods
MEDLINE, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally fed critically ill adult patients were included.

Results
Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU).

Conclusion
It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro, or synbiotics have no significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea.
25 Years of the International Bipolar Collaborative Network (BCN)
Authors: Post Robert M. , Altshuler Lori L. , Kupka Ralph , McElroy Susan L. , Frye Mark A. , Grunze Heinz , Suppes Trisha , Keck Paul E. , Nolen Willem A. 
Published: April 2021

Abstract
Background
The Stanley Foundation Bipolar Treatment Outcome Network (SFBN) recruited more than 900 outpatients from 1995 to 2002 from 4 sites in the United States (US) and 3 in the Netherlands and Germany (abbreviated as Europe). When funding was discontinued, the international group of investigators continued to work together as the Bipolar Collaborative Network (BCN), publishing so far 87 peer-reviewed manuscripts. On the 25th year anniversary of its founding, publication of a brief summary of some of the major findings appeared appropriate. Important insights into the course and treatment of adult outpatients with bipolar disorder were revealed and some methodological issues and lessons learned will be discussed.

Results
The illness is recurrent and pernicious and difficult to bring to a long-term remission. Virtually all aspects of the illness were more prevalent in the US compared to Europe. This included vastly more patients with early onset illness and those with more psychosocial adversity in childhood; more genetic vulnerability; more anxiety and substance abuse comorbidity; more episodes and rapid cycling; and more treatment non-responsiveness.

Conclusions
The findings provide a road map for a new round of much needed clinical treatment research studies. They also emphasize the need for the formation of a new network focusing on child and youth onset of mood disorders with a goal to achieve early precision diagnostics for intervention and prevention in attempting to make the course of bipolar illness more benign.
Sensitivity of migratory connectivity estimates to spatial sampling design
Authors: Vickers Stephen H. , Franco Aldina M. A. , Gilroy James J. 
Published: April 2021

Abstract
Background
The use of statistical methods to quantify the strength of migratory connectivity is commonplace. However, little attention has been given to their sensitivity to spatial sampling designs and scales of inference.

Methods
We examine sources of bias and imprecision in the most widely used methodology, Mantel correlations, under a range of plausible sampling regimes using simulated migratory populations.

Results
As Mantel correlations depend fundamentally on the spatial scale and configuration of sampling, unbiased inferences about population-scale connectivity can only be made under certain sampling regimes. Within a contiguous population, samples drawn from smaller spatial subsets of the range generate lower connectivity metrics than samples drawn from the range as a whole, even when the underlying migratory ecology of the population is constant across the population. Random sampling of individuals from contiguous subsets of species ranges can therefore underestimate population-scale connectivity. Where multiple discrete sampling sites are used, by contrast, overestimation of connectivity can arise due to samples being biased towards larger between-individual pairwise distances in the seasonal range where sampling occurs (typically breeding). Severity of all biases was greater for populations with lower levels of true connectivity. When plausible sampling regimes were applied to realistic simulated populations, accuracy of connectivity measures was maximised by increasing the number of discrete sampling sites and ensuring an even spread of sites across the full range.

Conclusions
These results suggest strong potential for bias and imprecision when making quantitative inferences about migratory connectivity using Mantel statistics. Researchers wishing to apply these methods should limit inference to the spatial extent of their sampling, maximise their number of sampling sites, and avoid drawing strong conclusions based on small sample sizes.
Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway
Authors: Wen Jian , Chen Hanren , Ren Zhongyu , Zhang Peng , Chen Jianjiao , Jiang Shulian 
Published: April 2021

AbstractIron-based nanoparticles, which could elicit ferroptosis, is becoming a promising new way to inhibit tumor cell growth. Notably, ultrasmall iron oxide nanoparticles (USIONPs) have been found to upregulate the autophagy process in glioblastoma (GBM) cells. Whether USIONPs could also elicit ferroptosis and the relationship between the USIONPs-induced autophagy and ferroptosis need to be explored. In the current study, our synthesized USIONPs with good water solubility could significantly upregulate the ferroptosis markers in GBM cells, and downregulate the expression of anti-ferroptosis genes. Interestingly,ferrostatin-1 could reverse USIONPs- induced ferroptosis, but inhibitors of apoptosis, pyroptosis, or necrosis could not. Meanwhile, autophagy inhibitor 3-methyladenine could also reverse the USIONPs-induced ferroptosis. In addition, shRNA silencing of upstream genes Beclin1/ATG5 of autophagy process could significantly reverse USIONPs-induced ferroptosis, whereas overexpression of Beclin1/ATG5 of autophagy process could remarkably promote USIONPs-induced ferroptosis. Furthermore, lysosome inhibitors could significantly reverse the USIONPs-induced ferroptosis. Collectively, these facts suggest that USIONPs-induced ferroptosis is regulated via Beclin1/ATG5-dependent autophagy pathway.
Recovery and evaluation of cellulose from agroindustrial residues of corn, grape, pomegranate, strawberry-tree fruit and fava
Authors: Vallejo Mariana , Cordeiro Rachel , Dias Paulo A. N. , Moura Carla , Henriques Marta , Seabra Inês J. , Malça Cândida Maria , Morouço Pedro 
Published: April 2021

AbstractConsidering the expected increasing demand for cellulose fibers in the near future and that its major source is wood pulp, alternative sources such as vegetable wastes from agricultural activities and agro-food industries are currently being sought to prevent deforestation. In the present study, cellulose was successfully isolated from six agroindustrial residues: corncob, corn husk, grape stalk, pomegranate peel, marc of strawberry-tree fruit and fava pod. Cellulose fibers were characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, stereomicroscopy and scanning electron microscopy (SEM). Despite the evident morphological differences among the extracted celluloses, results revealed similar compositional and thermal properties with the wood-derived commercial microcrystalline cellulose used as a control. Trace amounts of lignin or hemicellulose were detected in all cellulose samples, with the exception of corncob cellulose, that exhibited the greatest extraction yield (26%) and morphological similarities to wood-derived microcrystalline cellulose, visible through SEM. Furthermore, corncob cellulose was found to have thermal properties (TOnset of 307.17 °C, TD of 330.31 °C, and ΔH of 306.04 kJ/kg) suitable for biomedical applications.
Occurrence of Escherichia coli non-susceptible to quinolones in faecal samples from fluoroquinolone-treated, contact and control pigs of different ages from 24 Swiss pig farms
Authors: Amsler Morena , Zurfluh Katrin , Hartnack Sonja , Sidler Xaver , Stephan Roger , Kümmerlen Dolf 
Published: April 2021

Abstract
Background
Despite their indispensability in human medicine, fluoroquinolones (FQ) are used for the treatment of bacterial infections in farm animals which increases the risk of transferring FQ-resistant bacteria into the environment and via the food chain to humans. The objectives of this observational study were to follow-up of the presence of quinolone non-susceptible Escherichia coli (QNSE) qualitatively and quantitatively in faecal samples of pigs at four time points (2 weeks old, 4 weeks old, 2 weeks post weaning and during fattening period). Moreover differences between groups of FQ-treated pigs, pigs with contact to treated pigs and control pigs were investigated. Additionally, quinolone and FQ resistance of Escherichia coli isolates of the faecal samples were investigated by determining minimum inhibitory concentrations (MICs).

Results
40.9% of 621 fecal samples contained QNSE. Proportion of samples with detectable QNSE from treated and contact pigs did not differ significantly and were highest in piglets of 2 and 4 weeks of age. However, the proportions of samples with QNSE were significantly lowest in control pigs (7/90; 7.8%; CI = 3.5–14.7%) among all groups. Also, the number of colony-forming units was lowest in both weaners and fattening pigs of the control group compared to treated and contact groups. Following CLSI human breakpoints, in total, 50.4% out of 254 isolates in faecal samples were intermediate or resistant to ciprofloxacin.

Conclusions
QNSE were present in faeces of pigs independent of age or FQ background but significantly less were found in pigs from farms without FQ usage. Due to the long half-life of FQ, it is likely that only a prolonged absence of fluoroquinolone treatments in pig farming will lead to a reduced frequency of QNSE in the farm environment. Solutions need to be found to minimise the emergence and transfer of quinolone and FQ-resistant bacteria from treated pigs to contact pigs and to farms without FQ usage.
Single and multi-area multi-fuel economic dispatch using a fuzzified squirrel search algorithm
Authors: Sakthivel V. Ponnuvel , Sathya P. Duraisamy 
Published: April 2021

AbstractMulti-Area Multi-Fuel Economic Dispatch (MAMFED) aims to allocate the best generation schedule in each area and to offer the best power transfers between different areas by minimizing the objective functions among the available fuel alternatives for each unit while satisfying various constraints in power systems. In this paper, a Fuzzified Squirrel Search Algorithm (FSSA) algorithm is proposed to solve the single-area multi-fuel economic dispatch (SAMFED) and MAMFED problems. Squirrel Search Algorithm (SSA) mimics the foraging behavior of squirrels based on the dynamic jumping and gliding strategies. In the SSA approach, predator presence behavior and a seasonal monitoring condition are employed to increase the search ability of the algorithm, and to balance the exploitation and exploration. The suggested approach considers the line losses, valve point loading impacts, multi-fuel alternatives, and tie-line limits of the power system. Because of the contradicting nature of fuel cost and pollutant emission objectives, weighted sum approach and price penalty factor are used to transfer the bi-objective function into a single objective function. Furthermore, a fuzzy decision strategy is introduced to find one of the Pareto optimal fronts as the best compromised solution. The feasibility of the FSSA is tested on a three-area test system for both the SAMFED and MAMFED problems. The results of FSSA approach are compared with other heuristic approaches in the literature. Multi-objective performance indicators such as generational distance, spacing metric and ratio of non-dominated individuals are evaluated to validate the effectiveness of FSSA. The results divulge that the FSSA is a promising approach to solve the SAMFED and MAMFED problems while providing a better compromise solution in comparison with other heuristic approaches.
Part 1: exploring views from fathers and perinatal practitioners on the inclusion of fathers by perinatal services
Authors: Fenton SK , Joscelyne T , Higgins S 
Published: April 2021

BackgroundThis is the first of a two-part series exploring father's inclusion in the perinatal years. Part 2 will explore the results of the study and discuss in relation to previous literature and to professional practice. Positive father involvement during the perinatal period has important implications for families. However, previous research suggests that fathers experience marginalisation, while staff report a lack of training and time for engaging fathers.AimsThis study explored fathers' and perinatal professionals' experiences of fathers' involvement during the perinatal period, and ideas for paternal support.MethodA Delphi method was employed. Thematic analysis from focus groups informed an online survey which was completed by 24 fathers and 22 professionals. A third-round survey finalised group consensus.ResultsBoth groups agreed on the importance of fathers. Participants suggested improvement ideas, such as supporting fathers with psychological change. Groups disagreed on some ideas, such as fathers receiving a session alone to discuss concerns.DiscussionThe findings support the inclusion of fathers in perinatal services, and a focus on the whole family system. Limitations of this study include low participant diversity and possible selection bias. Implications for further research are discussed.
Conversations of opportunity in diabetes care
Authors: Phillips Anne 
Published: April 2021

Anne Phillips explores the ways in which diabetes consultations can be maximised to deliver the best effects for people living with diabetes and health professionals involved in their care Changes to diabetes care due to the COVID-19 pandemic have caused extra pressures for both people living with diabetes and the health professionals involved in their care. Virtual and remote consulting has caused many health professionals to experience stress and usual face-to-face conversations with people living with diabetes have changed in context, frequency and delivery. The nuances of non-verbal communication can be lost in virtual consultations, so it is vitally important that health professionals are aware of this and consider how to deliver consultation conversations to the best effect. It is imperative that every contact counts and every virtual and face-to-face consultation has meaning for the person living with diabetes to maximise the benefit for the individual and their circumstances.