bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Never sacrifice anything to laboratory work”: The “physiological psychology” of Charles Richet (1875–1905)
Authors: Evrard Renaud , Gumpper Stéphane , Beauvais Bevis , Alvarado Carlos S. 
Published: February 2021

AbstractWhilst best known as a Nobel laureate physiologist, Charles Robert Richet (1850–1935) was also a pioneer of scientific psychology. Starting in 1875 Richet had a leading role in the habilitation of hypnosis, in the institutionalization of psychology in France, and in the introduction of methodological innovations. Authoring several psychology books, Richet's works contributed to the recognition of the scientific nature of the discipline. This role is often underplayed by some historians and psychology textbooks in favor of his later position as a proponent of the controversial discipline he christened metapsychics in 1905, which today lies within the province of parapsychology. In this article, we show how his psychological approach guided by physiology, or physiological psychology, facilitated the reception of psychology. We hypothesize a strong continuity between his physiological psychology and his metapsychics, as he himself considered metapsychics as an advanced branch of physiology, and thus also an outpost of psychology.
Prenatal development in Lagostomus maximus (Rodentia, Chinchillidae): A unique case among eutherian mammals of physiological embryonic death
Authors: Acuña Francisco , Barbeito Claudio G. , Portiansky Enrique L. , Miglino María A. , Flamini Mirta A. 
Published: February 2021

AbstractEmbryonic death followed by resorption is a conserved process in mammals. Among the polyovular species, Lagostomus maximus (plains viscacha) constitutes a model of early and physiological embryonic death, since out of a total of 10–12 implants, 8–10 are resorbed during early/intermediate gestation, surviving are only the most caudal implantations of each uterine horn. This regular reproductive event is unique to this species, but many characteristics of the implantations during the early gestation of L. maximus, when embryonic death processes begin are unknown. The aim of the present work was to analyze the implantation sites of this species using morphological, morphometric, histochemical, lectinhistochemical, and immunohistochemical techniques to infer the possible causes of this event. Macroscopically, the length and width of the implantation sites significantly increased in a craniocaudal direction. Histochemically, the implantation sites did not differ in the expression of glycoconjugates and glycosidic residues. Furthermore, no variations were observed in cell renewal, hormone receptor expression, and decidualization. Both the glandular and vascular areas of the implantation sites significantly increased in the craniocaudal axis. Some necrotic cells and an inflammatory response with a predominance of lymphocytes and fibrin were observed in the cranial and middle but not in the caudal implantation sites. We conclude that signs of embryonic death and resorption are already observed in the early gestation of L. maximus. Our results reaffirm the hypothesis that postulates the key potential role of uterine glands and blood vessels in the gestation of the species, with emphasis on embryonic death. This pattern of embryonic death in L. maximus makes this species an unconventional mammalian model, which adds to the peculiarities of polyovulation (200–800 oocytes/estrus) and hemochorial placentation.
Catholic priests in the Archdiocese of Jakarta: Evidence of entrepreneurial leadership
Authors: Wulandari Respati , Zoubir Yahia H. 
Published: February 2021

AbstractThe Catholic Archdiocese of Jakarta, Indonesia, has existed for more than 200 years. Throughout its development, it has faced numerous internal and external challenges. To address these challenges, the role of parish priests has changed from being primarily that of a religious leader, to include being a leader and manager of an organization. Using a theoretical framework of entrepreneurial leadership consisting of 14 precursors, and conducting interviews with 19 priests in charge of parishes, this article shows how the parish priests in the Archdiocese of Jakarta behave as entrepreneurs. It illustrates entrepreneurial behavior within the Church, which, unlike for‐profit organizations, is not orientated towards financial growth. The study shows that the 14 precursors of entrepreneurial leadership can also be applied to the activities of Roman Catholic priests in Jakarta. It lays the groundwork for further research by grouping the 14 precursors into three new categories. It also demonstrates that entrepreneurial leadership in non‐profit activities mirrors entrepreneurial leadership in for‐profit organizations, with the main difference being that there is no material (financial) expectation.
Retail employee theft: When retail security alone is not enough
Authors: Korgaonkar Pradeep , Becerra Enrique P. , Mangleburg Tamara , Bilgihan Anil 
Published: February 2021

AbstractRetailers and local governments lose revenue, and inevitably consumers pay higher prices due to theft. In 2018, the amount lost to employee theft per incident was $1361. This is in comparison to the amount per incident lost to shoplifting of $302. Despite this difference, the scholarly attention in marketing on retail employee theft is sparse. The current study aims to fill this gap. The framework developed and tested is based on routine activity theory, the theory of reasoned action and findings from the retailing and management literature. Data were collected from a national sample of 665 retail employees. The framework simultaneously examines the influence of attitudes, antecedents, and social norms regarding stealing on employee intentions to steal and the influence of a moral compass and organizational commitment on attitudes toward stealing and intentions to steal. Results indicate that attitudes toward stealing are driven by the availability of suitable targets, the absence of guardianship, and a moral compass. Behavioral intentions to steal are influenced by attitudes toward stealing, suitable targets (but indirectly), and the employee's level of employment.
Understanding the potential adoption of autonomous vehicles in China: The perspective of behavioral reasoning theory
Authors: Huang Youlin , Qian Lixian 
Published: February 2021

AbstractPowered by artificial intelligence (AI), autonomous vehicles (AVs) are one of the most disruptive technologies to reduce road incidents, improve road efficiency and enhance mobility for underserved populations. However, existing literature of AV adoption is either based on descriptive analysis or simple applications of conventional behavioral frameworks. Drawing on behavioral reasoning theory (BRT), we examine the effect of reasoning process on consumers' attitudes and intentions toward adopting AVs, and how their psychological traits moderates the relationships. By conducting a nationwide survey in China (n = 849), we identify positive (negative) effects of individuals' reasons for (against) adopting AVs on their adoption intentions for AVs, and positive influence of face consciousness on the reasoning process. More importantly, we find that the psychological trait of need for uniqueness strengthens the association between consumers' reasoning for AVs and their adoption intention, while the risk aversion trait intensifies the negative relationships between consumers' reasoning against AVs and their attitude/adoption intention. We contribute to the literature of AI adoption by establishing the important roles of consumers' reasons for and against such innovations. We also extend the BRT framework by identifying the roles of psychological traits in moderating the relationships among reasoning, attitude, and adoption intention.
The adoption of AI service robots: A comparison between credence and experience service settings
Authors: Park Sungjun S. , Tung ChunTing D. , Lee Heejung 
Published: February 2021

AbstractWould consumers experience the same psychological processes when adopting AI service robots in different service areas? Results of multigroup structural equation modeling (n = 517) indicate that consumers' psychological processes are not the same in different service areas. Specifically, how consumers perceive AI service robots' usefulness is shown to be a significant underlying mechanism affecting consumers' attitudes toward adopting AI service robots in a service setting with a credence attribute (e.g., a hospital), but is not significant for a service setting with an experience attribute (e.g., a café). Furthermore, regardless of the different service settings, both privacy concerns and trust toward AI technology are shown to be significant antecedents, consistent with previous literature. Our results provide empirical insights at the intersection of psychology, marketing, and AI technology on how consumers adapt to using service robots across different service areas.
The investigation of genetic and clinical features in patients with hereditary spastic paraplegia in central‐Southern China
Authors: Wang Chen , Zhang Yun‐Jian , Xu Ci‐Hao , Li De , Liu Zhi‐Jun , Wu Yan 
Published: February 2021

AbstractObjectiveHereditary spastic paraplegias (HSP) is a clinically and genetically heterogeneous group of neurodegenerative disorders. We describe the genetic and clinical features of a cohort of five HSP families from central‐southern China.MethodsUsing targeted exome‐sequencing technology, we investigated the genetic and clinical features in five HSP families. We reviewed the clinical histories of these patients as well as the molecular and functional characterization of the associated gene variants. We also performed functional analysis of an intron variant of SPAST in vitro.ResultsWe identified a known SPAST mutation (p.Pro435Leu) in a family with autosomal dominant HSP (AD‐HSP) and four novel variants in two HSP families and a sporadic case. These identified four novel variants included a variant in SPG11 (p.Val1979Ter), two variants in B4GALNT1 (p.Ser475Phe and c.1002 + 2 T > G), and a splicing site variant in SPAST (c.1245+5G>A). Minigene analysis of the splicing variant in SPAST (c.1245+5G>A) revealed that the mutation resulted in mRNAs with a loss of exon 9. The SPG4 family carrying c.1245+5G>A variant in SPAST exhibited genetic anticipation, with a decreased age at onset and increased severity in successive generations. The proband with p.Val1979Ter variant in SPG11 showed characteristic clinical features of early‐onset, severe spasticity, and corpus callosum atrophy which were highly suggestive of the diagnosis of SPG11‐associated HSP.ConclusionsOur findings strongly support variable phenotype of B4GALNT1‐related SPG26 and also expand the clinical and mutation spectrum of HSP caused by mutations in SPAST, SPG11, and B4GALNT1. These results will help to improve the efficiency of early diagnosis in patients clinically suspected of HSP.
Genetic etiology study of four Chinese families with two nonsyndromic deaf children in succession by targeted next‐generation sequencing
Authors: Xiao Caixia , Liu Shuang , Wang Hongyue , Ding Yibing , Chen Yaqiu , Liu Haiyan 
Published: February 2021

AbstractBackgroundGenetic components contribute significantly to the cause of hearing loss. Nonsyndromic hearing loss has been shown to have high genetic heterogeneity. For families who had given birth to two nonsyndromic deaf children in succession, it seems that their deafness was highly related to genetics.ObjectivesThis study aimed to disclose the genetic causes of the subjects from the four Chinese families with two nonsyndromic deaf children in succession who failed to find the genetic etiology of the hearing loss by common deafness genetic screening (GJB2, GJB3, SLC26A4, and MT‐RNR1, including 20 hot variants in 4 genes).MethodsTargeted next‐generation sequencing (NGS) of 127 known deafness genes was performed in probands of four families, followed by a series of comprehensive analyses of all family members combined with a literature review of related genes.ResultsWe identified pathogenic variants in three families including c.919‐2A>G/c.1985G>A in SLC26A4; c.109G>A (p.V37I) in GJB2; and m.7505T>C in MT‐TS1. Sanger sequencing confirmed that these variants segregated with the hearing impairment of each family. We also identified c.331C>T/c.625‐5C>T/c.5717G>A in CDH23; c.138T>C in POU3F4 in two families, in which the pathogenicity in clinical was likely pathogenic or unknown.ConclusionsUsing the NGS detection technology, we found the genetic etiology of the HL in part of deaf families. Our study provided a useful piece of information for the variant spectrum of hearing loss in Chinese families with two deaf children in succession.
CUL4B renders breast cancer cells tamoxifen‐resistant via miR‐32‐5p/ER‐α36 axis
Authors: Wang Yuxing , Pan Xiaohua , Li Yanjun , Wang Ru , Yang Yuanyuan , Jiang Baichun , Sun Gongping , Shao Changshun , Wang Molin , Gong Yaoqin 
Published: February 2021

AbstractTamoxifen (TAM) resistance is a significant clinical challenge in endocrine therapies for estrogen receptor (ER)‐positive breast cancer patients. Cullin 4B (CUL4B), which acts as a scaffold protein in CUL4B–RING ubiquitin ligase complexes (CRL4B), is frequently overexpressed in cancer and represses tumor suppressors through diverse epigenetic mechanisms. However, the role and the underlying mechanisms of CUL4B in regulating drug resistance remain unknown. Here, we showed that CUL4B promotes TAM resistance in breast cancer cells through a miR‐32‐5p/ER‐α36 axis. We found that upregulation of CUL4B correlated with decreased TAM sensitivity of breast cancer cells, and knockdown of CUL4B or expression of a dominant‐negative CUL4B mutant restored the response to TAM in TAM‐resistant MCF7‐TAMR and T47D‐TAMR cells. Mechanistically, we demonstrated that CUL4B renders breast cancer cells TAM‐resistant by upregulating ER‐α36 expression, which was mediated by downregulation of miR‐32‐5p. We further showed that CRL4B epigenetically represses the transcription of miR‐32‐5p by catalyzing monoubiquitination at H2AK119 and coordinating with PRC2 and HDAC complexes to promote trimethylation at H3K27 at the promoter of miR‐32‐5p. Pharmacologic or genetic inhibition of CRL4B/PRC2/HDAC complexes significantly increased TAM sensitivity in breast cancer cells in vitro and in vivo. Taken together, our findings thus establish a critical role for the CUL4B–miR‐32‐5p–ER‐α36 axis in the regulation of TAM resistance and have important therapeutic implications for combined application of TAM and the inhibitors of CRL4B/PRC2/HDAC complex in breast cancer treatment. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Peptide and protein engineering by modification of backbone and sidechain functional groups
Authors: Kordbacheh Shadi , Kasko Andrea M 
Published: February 2021

AbstractModifications of the sidechain and backbone of peptides and proteins are commonly used to improve their stability, to enhance their biological function, to enable and improve imaging and detection capabilities via conjugation to imaging agents and to otherwise introduce new properties. The most common approaches for modification and conjugation typically target amino acids such as lysine and cysteine. However, less abundant residues such as tyrosine, methionine and tryptophan are also potential targets for orthogonal modification. Non‐traditional modifications of common amino acids such as cysteine can also be used to introduce novel functional groups in a peptide sidechain. Additionally, modification via sortase is also very precise and site specific in biological conditions. This mini‐review article describes recent advances in selective modification reactions of peptides and proteins via these less common approaches. © 2021 Society of Industrial Chemistry.
Resistance to spirodiclofen in Brevipalpus yothersi (Acari: Tenuipalpidae) from Brazilian citrus groves: detection, monitoring, and population performance
Authors: M Rocha Claudiane , F Della Vechia Jaqueline , J Savi Patrice , Omoto Celso , J Andrade Daniel 
Published: February 2021

AbstractBACKGROUNDBrevipalpus yothersi mite is the main vector of Citrus leprosis virus (CiLV), the causal agent of citrus leprosis disease. The acaricide spirodiclofen has been widely used to control this mite. However, failures in control using spirodiclofen have been frequently reported by citrus growers. In this study, we estimated the diagnostic concentration to monitor the resistance to spirodiclofen of B. yothersi populations collected in nine citrus groves in Brazil. We then selected the B. yothersi population that showed lowest mortality with the estimated diagnostic concentration of spirodiclofen to characterize the frequency of resistant individuals, as well as demographic and life table parameters.RESULTSVariability was higher between populations in terms of susceptibility to spirodiclofen. The frequency of resistant eggs between populations ranged from 0.7% to 85.8%. The resistance ratio of B. yothersi to spirodiclofen was low to moderate. Survival rates of the immature stage, total adult longevity, oviposition days, and female fecundity were lower in the resistant strain. Furthermore, net reproduction rate, intrinsic rate of increase, finite rate of increase, and mean length of a generation were also lower in the R strain.CONCLUSIONAlthough variations in resistance to spirodiclofen were observed between populations, the resistance ratio was low to moderate. Such data can be useful in the development of resistance management strategies for B. yothersi in Brazilian citrus groves. © 2021 Society of Chemical Industry.
Supporting Scientific Discussions: Moving Kindergartners’ Conversations Forward
Authors: West JoAnne M. , Wright Tanya S. , Gotwals Amelia W. 
Published: February 2021

AbstractBackground knowledge and oral language have long been linked to reading and writing outcomes. Discussions are one way to build both oral language and background knowledge. Nevertheless, designing discussions to support children’s content knowledge and oral language development, as well as build discipline specific speaking practices, can prove challenging. This article describes discussions in one kindergarten classroom during a unit on force and motion. Throughout the unit, children were supported to discuss force and motion in multiple ways and across different types of activities.
Incremental treatments of the full configuration interaction problem
Authors: Eriksen Janus J. , Gauss Jürgen 
Published: February 2021

AbstractThe recent many‐body expanded full configuration interaction (MBE‐FCI) method is reviewed by critically assessing its advantages and drawbacks in the context of contemporary near‐exact electronic structure theory. Besides providing a succinct summary of the history of MBE‐FCI to date within a generalized and unified theoretical setting, its finer algorithmic details are discussed alongside our optimized computational implementation of the theory. A selected few of the most recent applications of MBE‐FCI are revisited, before we close by outlining its future research directions as well as its place among modern near‐exact wave function‐based methods.This article is categorized under:
Electronic Structure Theory > Ab Initio Electronic Structure Methods
No-scale hybrid inflation with R-symmetry breaking
Authors: Moursy Ahmad 
Published: February 2021

Abstract
In this paper we provide a no-scale supergravity scenario of hybrid inflation with R-symmetry being broken maximally. We investigate the inflation dynamics in details in both cases of pure F-term hybrid inflation and when adding constant Fayet-Iliopoulos D-terms. The effective inflation potential is asymptotically flat in a region of the parameter space in both cases. We explore all regions in the parameter space when discussing the constraints from the observables. We point out a connection between inflation, R-symmetry breaking and GUT scales. The moduli backreaction and SUSY breaking effects are investigated in a specific stabilization mechanism. We emphasis that a successful reheating is not affected by R-symmetry breaking, but it has interesting consequences. We study the reheating in flipped GUT model. We argue in favor of Z2 symmetry associated with flipped GUT models to avoid phenomenologically dangerous operators and allow for decay channels for the inflaton to right-handed neutrinos (sneutrinos).
Atmospheric CO2 availability induces varying responses in net photosynthesis, toxin production and N2 fixation rates in heterocystous filamentous Cyanobacteria (Nostoc and Nodularia)
Authors: Wannicke Nicola , Herrmann Achim , Gehringer Michelle M. 
Published: February 2021

AbstractHeterocystous Cyanobacteria of the genus Nodularia form major blooms in brackish waters, while terrestrial Nostoc species occur worldwide, often associated in biological soil crusts. Both genera, by virtue of their ability to fix N2 and conduct oxygenic photosynthesis, contribute significantly to global primary productivity. Select Nostoc and Nodularia species produce the hepatotoxin nodularin and whether its production will change under climate change conditions needs to be assessed. In light of this, the effects of elevated atmospheric CO2 availability on growth, carbon and N2 fixation as well as nodularin production were investigated in toxin and non-toxin producing species of both genera. Results highlighted the following:

Biomass and volume specific biological nitrogen fixation (BNF) rates were respectively almost six and 17 fold higher in the aquatic Nodularia species compared to the terrestrial Nostoc species tested, under elevated CO2 conditions.

There was a direct correlation between elevated CO2 and decreased dry weight specific cellular nodularin content in a diazotrophically grown terrestrial Nostoc species, and the aquatic Nodularia species, regardless of nitrogen availability.

Elevated atmospheric CO2 levels were correlated to a reduction in biomass specific BNF rates in non-toxic Nodularia species.

Nodularin producers exhibited stronger stimulation of net photosynthesis rates (NP) and growth (more positive Cohen’s d) and less stimulation of dark respiration and BNF per volume compared to non-nodularin producers under elevated CO2 levels.

This study is the first to provide information on NP and nodularin production under elevated atmospheric CO2 levels for Nodularia and Nostoc species under nitrogen replete and diazotrophic conditions.