bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using the Behaviour Change Wheel to design an intervention for partner abusive men in drug and alcohol treatment
Authors: Gilchrist Elizabeth , Johnson Amy , McMurran Mary , Stephens-Lewis Danielle , Kirkpatrick Sara , Gardner Benjamin , Easton Caroline , Gilchrist Gail 
Published: October 2021

Abstract
Background
We aimed to establish what core elements were required in a group therapy programme for men who disclose perpetrating intimate partner abuse in a substance use setting and develop, and test the feasibility of delivering an intervention in this setting.

Methods
We describe the theoretical development and feasibility testing of an integrated substance use and intimate partner abuse intervention (‘ADVANCE’) for delivery in substance use services. We employed a comprehensive eight-stage process to guide this development applying the ‘COM-B’ (‘capability’, ‘opportunity’, ‘motivation’ and ‘behaviour’) model for intervention design which specifies the following: (1) define the problem, (2) select the target behaviour, (3) specify the target behaviour, (4) identify what needs to change, (5) identify intervention functions, (6) identify policy categories, (7) select behaviour change techniques, and (8) design a mode of delivery. The development was informed by primary research conducted by the authors, consulting with organisation steering groups and by those with personal experiences. The identified targets for intervention and mode and method of delivery were then refined over 4 intervention development meetings, using the nominal group technique with the ADVANCE experts, then further refined following consultation with service user groups and wider expert groups via a learning alliance meetings.

Results
Our final intervention, the ADVANCE intervention consisted of a group intervention comprising of up to four pre-group individual interviews, followed by 12 × 2-h group sessions supported by integrated safety work for victim/survivors, and risk and safety support and integrity support for the professionals. The main targets for change were personal goal planning, self-regulation, and attitudes and beliefs supporting intimate partner abuse. The intervention was regarded as very acceptable to both staff and clients in substance use services, with group attendees reported positive behaviour changes and development of new skills.

Conclusion
We have demonstrated the ability to employ a structured eight-step process to develop an integrated intervention to address substance use-related intimate partner abuse that is acceptable to staff and clients in substance use services. This led to a feasibility study (ISRCTN 79435190) involving 104 men and 30 staff at three different locations across the UK was conducted to assess the feasibility and acceptability of the intervention and to refine the content and approach to delivery (BMC Public Health, 21: 980, 2021).
Adherence to antihypertensive medications in rural Lao PDR: a prospective observational study
Authors: Takahashi Emiri , Vilay Phoutnalong , Chanthakoummane Ketmany , Pongvongsa Tiengkham , Kounnavong Sengchanh , Kano Shigeyuki , Kobayashi Jun , Nonaka Daisuke 
Published: October 2021

Abstract
Background
Although hypertension is becoming more prevalent among the adult population of the Lao People’s Democratic Republic (PDR), with a prevalence of approximately 20% in 2013, treatment adherence of patients with hypertension, especially those in rural areas, remains poorly understood. The objective of the present study was to examine the rate of medication adherence to antihypertensive medicines among outpatients with hypertension in rural districts of the Savannakhet.

Methods
A prospective observational study was conducted in Xepon, Phin, and Nong districts. The study population was outpatients aged 18 years or older who were prescribed antihypertensive medicines at three district hospitals between February and August 2017. Data were collected on the first day of treatment (day 0) and the day of follow-up (around day 7) through interviews with the patients and outpatient registration books. The medication adherence rate was determined using the four-item Morisky Medication Adherence Scale. The level of adherence was evaluated by the sum of the scale, with scores ranging from 0 to 4 points. The adherent group, namely those with a score of 0, and the non-adherent group, namely those with scores of 1 to 4 points, were compared. Fisher’s exact test was used to identify factors associated with medication adherence.

Results
Of the 68 patients examined, 38.2% newly began treatment. Half of the patients (n = 34, 50.0%, 95% CI 0.38 to 0.62) adhered to medication instructions. The adherent group was more likely to have received written instructions when prescribed medication, compared to the non-adherent group (79.4% vs 55.9%, p = 0.068). Those who perceived that hypertension needs lifelong treatment were significantly more likely to adhere to the medication regimen (p = 0.028).

Conclusions
Medication adherence was present among 50% of outpatients with hypertension who visited a district hospital. Therefore, providing written instructions to patients would be effective for improving medication adherence.
Physiotherapists’ perception of physicians’ referral of patients for physiotherapy in the Nigerian health system
Authors: Okonkwo Uchenna Prosper , Ihegihu Ebere Yvonne , Maruf Fatai Adesina , Umunnah Joseph Onuwa , Maduagwu Stanley Monday , Okoye Emmanuel Chiebuka , Okeke Chukwuebuka Olisaemeka 
Published: October 2021

Abstract
Background
As the physiotherapy profession gradually evolves into a more autonomous profession, physicians continue to play a major role in the clinical practice of physical therapists globally, particularly as a source of patient referral. Therefore, an evaluation of Nigerian physiotherapists’ (NPTs) perception of physician’s referral (PR) of patients for physiotherapy may be a critical indicator of the relationship between the two professionals in the Nigerian health sector. The objective of the study was to determine the perception of Nigerian NPTs on the PR of patients for physiotherapy and the influence of demographic characteristics on the perception. The study was an online survey involving one hundred and fifty-four respondents. The instrument for the study was an 11-item self-developed questionnaire with two domains: demographics and perception. The participants were blind respondents reached through different physiotherapists’ WhatsApp platforms in Nigeria. The responses were collated electronically after 2 months and analyzed with the Statistical Package for Social Sciences (SPSS) version 23.

Results
The respondents have a negative perception of the 9 out of the 11-questionnaire items that were used to test the physiotherapists’ perception of the physicians’ referral of patients for physiotherapy in Nigeria health facilities. There was no significant difference (p>0.05) across the respondents’ gender, place of employment, areas of specialization, and educational qualifications and the respondents’ perception of doctors’ referrals of patients for physiotherapy. However, there was a significant difference (p<0.05) in each of the participants’ perceptions across the respondents’ years of practice, with the participants who had less than 5 years of practice having the least score.

Conclusions
Nigerian physiotherapists have a negative perception of physicians’ referral of patients for physiotherapy, and the perception was only influenced by the years of practice of the respondents.
Increased suicidal ideation in the COVID-19 pandemic: an employee cohort in Japan
Authors: Sasaki Natsu , Kuroda Reiko , Tsuno Kanami , Imamura Kotaro , Kawakami Norito 
Published: October 2021

Objectives
This study investigated the change in suicidal ideation and its risk factors among employees. A longitudinal cohort study was conducted, starting with the baseline online survey in March 2020 (T1), followed by May (T2), and August (T3). The change in suicidal ideation from T2 to T3 and relevant factors associated with suicidal ideation at T3 were examined. Suicidal ideation significantly increased between May and August 2020 among females, younger (under 39 years old), highly educated population, and those without pre-existing mental health conditions. Factors significantly associated with suicidal ideation were younger age, suicidal ideation at T2, and with pre-existing mental health conditions. Loneliness at T2 showed a significant association with suicidal ideation, if adjusting those without pre-existing mental health conditions. National and community support is needed to target people who are likely to be left behind, such as young people and those with pre-existing mental health conditions, in the pandemic.

Method
A longitudinal study was conducted with a cohort of full-time employees, starting with the baseline online survey in March 2020 (time point 1), followed by May (time point 2) and August (time point 3). The change in suicidal ideation from time point 2 to 3, and relevant factors associated with suicidal ideation at time point 3, were examined.

Results
Suicidal ideation significantly increased between time points 2 and 3 among women, younger people (aged <39 years), those who were highly educated and those without pre-existing mental health conditions. Factors significantly associated with suicidal ideation were younger age, suicidal ideation at time point 2 and pre-existing mental health conditions. Loneliness at time point 2 showed a significant association with suicidal ideation when adjusting for those without pre-existing mental health conditions.

Conclusions
National and community support is needed to target people who are likely to be left behind, such as young people, those with pre-existing mental health conditions and those experiencing loneliness, in the COVID-19 pandemic.
Mindfulness-based cognitive therapy added to usual care improves eating behaviors in patients with bulimia nervosa and binge eating disorder by decreasing the cognitive load of words related to body shape, weight, and food
Authors: Sala L. , Gorwood P. , Vindreau C. , Duriez P. 
Published: October 2021

Abstract

Background
This study aimed to investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) as a complementary approach in patients with bulimia nervosa (BN) or binge eating disorder (BED), and to assess how the reduction of the cognitive load of words related to eating disorders (ED) could constitute an intermediate factor explaining its global efficacy.

Methods
Eighty-eight women and men participated in clinical assessments upon inscription, prior to and following 8-week group MBCT. Mindfulness skills were assessed using the five facet mindfulness questionnaire; eating behaviors were assessed using the Three Factor Eating Questionnaire (TFEQ); comorbid pathologies were assessed using the beck depression index and the state-trait anxiety inventory. The cognitive load of words associated with ED was assessed through a modified version of the Stroop color naming task.

Results
Mindfulness skills improved significantly (p < .05) after group MBCT. The improvement of TFEQ scores was accompanied by reduced levels of depressive mood and trait anxiety. The positive impact of MBCT on TFEQ score was directly related to an improvement of the performance in the Stroop task.

Conclusions
MBCT represents an interesting complementary therapy for patients with either BN or BED, at least when cognitive and behavioral domains are concerned. Such efficacy seems to be mediated by the reduction of the cognitive load associated with ED stimuli, which offers a possible explanation of how MBCT could reduce binge-eating behaviors. Other studies are needed, in independent centers, to focus more directly on core symptoms and long-term outcome.
Infrastructure of Fertility Preservation Services for Pediatric Cancer Patients: A Report From the Children's Oncology Group
Authors: Frederick Natasha N. , Klosky James L. , Meacham Lillian R. , Quinn Gwendolyn P. , Kelvin Joanne Frankel , Cherven Brooke , Freyer David R. , Dvorak Christopher C. , Brackett Julienne , Ahmed-Winston Sameeya , Bryson Elyse , Chow Eric J. , Levine Jennifer 
Published: October 2021

PURPOSE: Fertility preservation (FP) services are part of comprehensive care for those newly diagnosed with cancer. The capacity to offer these services to children and adolescents with cancer is unknown. METHODS: A cross-sectional survey was sent to 220 Children's Oncology Group member institutions regarding institutional characteristics, structure and organization of FP services, and barriers to FP. Standard descriptive statistics were computed for all variables. The association between site-specific factors and selected outcomes was examined using multivariable logistic regression. RESULTS: One hundred forty-four programs (65.5%) returned surveys. Fifty-three (36.8%) reported a designated FP individual or team. Sperm banking was offered at 135 (97.8%) institutions, and testicular tissue cryopreservation at 37 (27.0%). Oocyte and embryo cryopreservation were offered at 91 (67.9%) and 62 (46.6%) institutions, respectively; ovarian tissue cryopreservation was offered at 64 (47.8%) institutions. The presence of dedicated FP personnel was independently associated with the ability to offer oocyte or embryo cryopreservation (odds ratio [OR], 4.7; 95% CI, 1.7 to 13.5), ovarian tissue cryopreservation (OR, 2.7; 95% CI, 1.2 to 6.0), and testicular tissue cryopreservation (OR, 3.3; 95% CI, 1.4 to 97.8). Only 26 (18.1%) participating institutions offered all current nonexperimental FP interventions. Barriers included cost (70.9%), inadequate knowledge or training (60.7%), difficulty characterizing fertility risk (50.4%), inadequate staffing (45.5%), and logistics with reproductive specialties (38%-39%). CONCLUSION: This study provides the most comprehensive view of the current landscape of FP infrastructure for children and adolescents with cancer and demonstrates that existing infrastructure is inadequate to offer comprehensive services to patients. We discuss modifiable factors to improve patient access to FP.
Understanding Drug Delivery to the Brain Using Liposome-Based Strategies: Studies that Provide Mechanistic Insights Are Essential
Authors: Juhairiyah Firda , de Lange Elizabeth C. M. 
Published: October 2021

AbstractBrain drug delivery may be restricted by the blood-brain barrier (BBB), and enhancement by liposome-based drug delivery strategies has been investigated. As access to the human brain is limited, many studies have been performed in experimental animals. Whereas providing interesting data, such studies have room for improvement to provide mechanistic insight into the rate and extent of specifically BBB transport and intrabrain distribution processes that all together govern CNS target delivery of the free drug. This review shortly summarizes BBB transport and current liposome-based strategies to overcome BBB transport restrictions, with the emphasis on how to determine the individual mechanisms that all together determine the time course offreedrug brain concentrations, following their administration as such, and in liposomes. Animal studies using microdialysis providing time course information on unbound drug in plasma and brain are highlighted, as these provide the mechanistic information needed to understand BBB drug transport of the drug, and the impact of a liposomal formulations of that drug on BBB transport. Overall, these studies show that brain distribution of a drug administered as liposomal formulation depends on both drug properties and liposomal formulation characteristics. In general, evidence suggests that active transporters at the BBB, either being influx or efflux transporters, are circumvented by liposomes. It is concluded that liposomal formulations may provide interesting changes in BBB transport. More mechanistic studies are needed to understand relevant mechanisms in liposomal drug delivery to the brain, providing an improved basis for its prediction in human using animal data.
Rethinking the Political Economy of Development in Mao's China
Authors: Meyskens Covell F. 
Published: October 2021

AbstractThis article examines two theoretical frameworks used to evaluate Maoist development. The first is based on neoclassical economic theory, and the second is rooted in the idea that the Chinese Communist Party made China into a state capitalist regime. Both these theoretical frameworks presume to know what economic practices the CCP should have engaged in and fault the Party for not conforming to their standards of judgment. This article finds this normative approach to analyzing Maoist development to be wanting for four reasons. In its drive to depict China as acting anomalously, this normative standpoint insufficiently attends to the empirical specificities of economic activities of the Mao era. It does not take enough into account how China's socialist identity shaped the CCP's economic initiatives. Nor does it dig deep enough into how the geopolitical dynamics of the Cold War influenced Chinese development. This way of writing the history of the Mao period also overlooks similarities between China and other developmental states in Cold War East Asia. This article calls on historians to adopt a different approach to the study of Chinese development and scour available documentation with the aim of comprehending the economic practices of Mao's China on their own terms.
Foundations of Theory in PRC History: Mass Communications Research, Political Culture, and the Values Paradigm
Authors: Johnson Matthew D. 
Published: October 2021

AbstractThis article describes the US origins of the field of PRC history. It argues that research on PRC history is widely derived from an approach to knowledge that predates area studies: the theory that societies can be controlled and changed through the transformation of human cognition—referred to as “public opinion,” “values,” “culture,” “political culture,” “tradition,” or “belief”—by nonviolent means. The author calls this approach to knowledge the values paradigm. A separate, but related argument is that this paradigm has proven more important than the availability or content of new sources in determining how PRC history has been written. The aim behind these arguments is twofold: to highlight the intellectual debt (or burden) that links PRC history, via area studies, to policy science; and to elucidate other ways of guiding research in place of the increasingly exhausted values paradigm–based approach. The conclusions they lead to are that historical and social scientific explanations of political change in China have become intellectually dependent on the abstraction of mass consciousness, and that this abstraction has been used to obscure the endemic violence of Maoism.
Syrian Men’s Disability and Their Masculine Trajectories in the Context of Displacement in Jordan and Turkey
Authors: Muhanna-Matar Aitemad 
Published: October 2021

AbstractThis article analyzes the relationship between men’s physical disability and the trajectories of negotiating masculinities in the context of Syrian refugee displacement in Jordan and Turkey. The article draws its analysis from the personal narratives of five displaced Syrian refugee men who sustained injuries during the war in Syria. It explores how Syrian refugee men with disabilities remake their masculine bodies and selves to create a new version of masculinity that responds to the changes in their socioeconomic circumstances and bodies. The article argues that the disabled Syrian refugee men went through multiple and contradictory masculine trajectories that intersect with multiple identities and different types of disability. Disabled Syrian refugee men’s emergent masculine embodiments created a version of masculinity that, although it adhered to the patriarchal family values of connectivity and intimacy, does not in its practice legitimate domination within the family and in the Syrian refugee community.
Muslim Fashionistas in Contemporary Turkey
Authors: Kütük-Kuriş Merve 
Published: October 2021

AbstractTurkey’s Islamic fashion market transformed during the 2010s with the entry of young, bourgeois, fashion-conscious Muslim female entrepreneurs. As designers, manufacturers, and retailers, these “Muslim fashionistas” not only gained the attention of young Muslim women but also became lifestyle gurus, projecting images of the successful entrepreneur, the ideal mother, the benevolent philanthropist, and the leisure enthusiast. This combination of roles resonates with the notion of the “ideal Muslim woman” promoted by the government. But its performance entails moments of imperfection and moral dilemma, as the demands of capitalism and consumerism place Muslim fashionistas in opposition to the teachings of their faith and traditional gender regimes. Drawing on practice theory, and on ethnographic fieldwork conducted in Istanbul, this article explores Muslim fashionistas’ everyday performances in the fields of family, charity, and leisure. The objective is to analyze how these agents negotiate and interpret quotidian inconsistencies between their religious and social ideals and those ideals’ manifestation.
Regulated inositol synthesis is critical for balanced metabolism and development in Drosophila melanogaster
Authors: Rivera Maria J. , Contreras Altagracia , Nguyen LongThy T. , Eldon Elizabeth D. , Klig Lisa S. 
Published: October 2021

ABSTRACT
Myo-inositol is a precursor of the membrane phospholipid, phosphatidylinositol (PI). It is involved in many essential cellular processes including signal transduction, energy metabolism, endoplasmic reticulum stress, and osmoregulation. Inositol is synthesized from glucose-6-phosphate by myo-inositol-3-phosphate synthase (MIPSp). The Drosophila melanogaster Inos gene encodes MIPSp. Abnormalities in myo-inositol metabolism have been implicated in type 2 diabetes, cancer, and neurodegenerative disorders. Obesity and high blood (hemolymph) glucose are two hallmarks of diabetes, which can be induced in Drosophila melanogaster third-instar larvae by high-sucrose diets. This study shows that dietary inositol reduces the obese-like and high-hemolymph glucose phenotypes of third-instar larvae fed high-sucrose diets. Furthermore, this study demonstrates Inos mRNA regulation by dietary inositol; when more inositol is provided there is less Inos mRNA. Third-instar larvae with dysregulated high levels of Inos mRNA and MIPSp show dramatic reductions of the obese-like and high-hemolymph glucose phenotypes. These strains, however, also display developmental defects and pupal lethality. The few individuals that eclose die within two days with striking defects: structural alterations of the wings and legs, and heads lacking proboscises. This study is an exciting extension of the use of Drosophila melanogaster as a model organism for exploring the junction of development and metabolism.