bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of accuracy, exclusivity, limit-of-detection and ease-of-use of LumiraDx™: An antigen-detecting point-of-care device for SARS-CoV-2
Authors: Krüger Lisa J. , Klein Julian A. F. , Tobian Frank , Gaeddert Mary , Lainati Federica , Klemm Sarah , Schnitzler Paul , Bartenschlager Ralf , Cerikan Berati , Neufeldt Christopher J. , Nikolai Olga , Lindner Andreas K. , Mockenhaupt Frank P. , Seybold Joachim , Jones Terry C. , Corman Victor M. , Pollock Nira R. , Knorr Britta , Welker Andreas , de Vos Margaretha , Sacks Jilian A. , Denkinger Claudia M. ,   ACE-IT Study Group, Assaad K. , Fuhs A. , Harter C. , Schulze C. , Schmitt G. , Klemmer Anja , Müller Rico , Fink Martina , Fougereau Mathilde , Schirmer Maximilian , Small Annika , Meinlschmidt Matthias , Dürr Valerie , Schuckert Alina , Backes Ann-Kathrin , Steinke Salome , Ellinghaus Henrik , Abutaima Loai , Kollatzsch Mandy , Wintel Mia , Kausch Franka , Hommes Franziska , Bölke Alisa , Bernhard Julian , Hülso Claudia , Linzbach Elisabeth , Rössig Heike , Gertler Maximilian , Burock Susen , von dem Busche Katja , Patberg Stephanie 
Published: August 2021

Abstract
Purpose
Rapid antigen-detecting tests (Ag-RDTs) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can transform pandemic control. Thus far, sensitivity (≤ 85%) of lateral-flow assays has limited scale-up. Conceivably, microfluidic immunofluorescence Ag-RDTs could increase sensitivity for SARS-CoV-2 detection.

Methods
This multi-centre diagnostic accuracy study investigated performance of the microfluidic immunofluorescence LumiraDx™ assay, enrolling symptomatic and asymptomatic participants with suspected SARS-CoV-2 infection. Participants collected a supervised nasal mid-turbinate (NMT) self-swab for Ag-RDT testing, in addition to a professionally collected nasopharyngeal (NP) swab for routine testing with reverse transcriptase polymerase chain reaction (RT-PCR). Results were compared to calculate sensitivity and specificity. Sub-analyses investigated the results by viral load, symptom presence and duration. An analytical study assessed exclusivity and limit-of-detection (LOD). In addition, we evaluated ease-of-use.

Results
The study was conducted between November 2nd 2020 and 4th of December 2020. 761 participants were enrolled, with 486 participants reporting symptoms on testing day. 120 out of 146 RT-PCR positive cases were detected positive by LumiraDx™, resulting in a sensitivity of 82.2% (95% CI 75.2–87.5%). Specificity was 99.3% (CI 98.3–99.7%). Sensitivity was increased in individuals with viral load ≥ 7 log10 SARS-CoV2 RNA copies/ml (93.8%; CI 86.2–97.3%). Testing against common respiratory commensals and pathogens showed no cross-reactivity and LOD was estimated to be 2–56 PFU/mL. The ease-of-use-assessment was favourable for lower throughput settings.

Conclusion
The LumiraDx™ assay showed excellent analytical sensitivity, exclusivity and clinical specificity with good clinical sensitivity using supervised NMT self-sampling.

Trial registration number and registration date
DRKS00021220 and 01.04.2020
Machine learning based approach for the interpretation of engineering geophysical sounding logs
Authors: Abordán Armand , Szabó Norbert Péter 
Published: August 2021

AbstractIn this paper, a set of machine learning (ML) tools is applied to estimate the water saturation of shallow unconsolidated sediments at the Bátaapáti site in Hungary. Water saturation is directly calculated from the first factor extracted from a set of direct push logs by factor analysis. The dataset observed by engineering geophysical sounding tools as special variants of direct-push probes contains data from a total of 12 shallow penetration holes. Both one- and two-dimensional applications of the suggested method are presented. To improve the performance of factor analysis, particle swarm optimization (PSO) is applied to give a globally optimized estimate for the factor scores. Furthermore, by a hyperparameter estimation approach, some control parameters of the utilized PSO algorithm are automatically estimated by simulated annealing (SA) to ensure the convergence of the procedure. The result of the suggested ML-based log analysis method is compared and verified by an independent inversion estimate. The study shows that the PSO-based factor analysis aided by hyperparameter estimation provides reliable in situ estimates of water saturation, which may improve the solution of environmental end engineering problems in shallow unconsolidated heterogeneous formations.
Geometry deviation effects of railway catenaries on pantograph–catenary interaction: a case study in Norwegian Railway System
Authors: Song Yang , Jiang Tengjiao , Nåvik Petter , Rønnquist Anders 
Published: August 2021

AbstractThis paper presents a non-contact measurement of the realistic catenary geometry deviation in the Norwegian railway network through a laser rangefinder. The random geometry deviation is included in the catenary model to investigate its effect on the pantograph–catenary interaction. The dispersion of the longitudinal deviation is assumed to follow a Gaussian distribution. A power spectrum density represents the vertical deviation in the contact wire. Based on the Monte Carlo method, several geometry deviation samples are generated and included in the catenary model. A lumped mass pantograph with flexible collectors is employed to reproduce the high-frequency behaviours. The stochastic analysis results indicate that the catenary geometry deviation causes a significant dispersion of the pantograph–catenary interaction response. The contact force standard deviations measured by the inspection vehicle are within the scope of the simulation results. A critical cut-off frequency that covers 1/16 of the dropper interval is suggested to fully describe the effect of the catenary geometry deviation on the contact force. The statistical minimum contact force is recommended to be modified according to the tolerant contact loss rate at high frequency. An unpleasant interaction performance of the pantograph–catenary can be expected at the catenary top speed when the random catenary geometry deviation is included.
Effects of methylenetetrahydrofolate reductase single‐nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities
Authors: Wang Zheng , Li Kai , Ouyang Ling , Iko Hidasa , Safi Ahmad Javid , Gao Shan 
Published: August 2021

AbstractBackgroundRecent studies identifying methylenetetrahydrofolate reductase (MTHFR) polymorphisms associated with breast cancer (BC), ovarian cancer (OC), cervical cancer, and endometrial cancer (EC) have reported conflicting results and been underpowered. To clarify the correlation between MTHFR mutations and these common female malignancies, we conducted a comprehensive meta‐analysis incorporating all eligible publications.MethodsRelevant reports published before January 20, 2020, were retrieved from PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure databases. The odds ratio and 95% confidence interval summaries for the MTHFR 677C/T and 1298A/C polymorphisms in BC, OC, cervical cancer, and EC were estimated.ResultsA total of 171 studies comprising 56,675 cancer cases and 67,559 controls were included. The results showed a markedly elevated risk of cancer susceptibility related to MTHFR 677C/T based on all genetic models. Similarly, we identified a significant correlation between 1298A/C mutation and cancer risk based on overall comparisons among all models, except the heterozygous model. Moreover, subgroup analysis by cancer type revealed a significantly increased risk of BC associated with 677C/T in the five models and of cervical cancer associated with 1298A/C in some models. Based on ethnicity, significant associations were observed between Asian, African, and mixed populations for 677C/T and the Asian population for 1298A/C. With regard to the sample type used for analysis, we detected a positive association between using blood as the DNA source and cancer risk for 677C/T in all genetic models and for 1298A/C in some genetic models. Further stratification of the results revealed that a notably increased risk was associated with the use of polymerase chain reaction‐restriction fragment‐length polymorphism or TaqMan as the genotyping method, as well as with the use of population‐or hospital‐based groups as the controls for 677C/T and 1298A/C, respectively.ConclusionThis meta‐analysis suggests that MTHFR 677C/T and 1298A/C polymorphisms correlate with the risk of common gynecological cancers, with these findings potentially applicable for overall comparisons of related data.
The Story of Blood for Shock Resuscitation: How the Pendulum Swings
Authors: Carmichael Samuel P. , Lin Nicholas , Evangelista Meagan E. , Holcomb John B. 
Published: August 2021

Whole blood transfusion (WBT) began in 1667 as a treatment for mental illness, with predictably poor results. Its therapeutic utility and widespread use were initially limited by deficiencies in transfusion science and antisepsis. James Blundell, a British obstetrician, was recognized for the first allotransfusion in 1825. However, WBT did not become safe and therapeutic until the early 20th century, with the advent of reliable equipment, sterilization, and blood typing. The discovery of citrate preservation in World War I allowed a separation of donor from recipient and introduced the practice of blood banking. During World War II, Elliott and Strumia were the first to separate whole blood into blood component therapy (BCT), producing dried plasma as a resuscitative product for “traumatic shock.”
During the 1970s, infectious disease, blood fractionation, and financial opportunities further drove the change from WBT to BCT, with few supporting data. Following a period of high-volume crystalloid and BCT resuscitation well into the early 2000s, measures to avoid the resulting iatrogenic resuscitation injury were developed under the concept of damage control resuscitation. Modern transfusion strategies for hemorrhagic shock target balanced BCT to reapproximate whole blood. Contemporary research has expanded the role of WBT to therapy for the acute coagulopathy of trauma and the damaged endothelium. Many US trauma centers are now using WBT as a front-line treatment in tandem with BCT for patients suffering hemorrhagic shock. Looking ahead, it is likely that WBT will once again be the resuscitative fluid of choice for patients in hemorrhagic shock.
Estimated Prevalence and Demographic Correlates of Compulsive Sexual Behavior Among Gay Men in the United States
Authors: Gleason Neil , Finotelli Itor , Miner Michael H. , Herbenick Debra , Coleman Eli 
Published: August 2021

ABSTRACTBackgroundCompulsive sexual behavior (CSB) is a clinical syndrome that causes significant distress and impairment for many individuals in the United States. Gay men are thought to have a higher prevalence of CSB, and it is associated with many relevant health outcomes including HIV risk behavior.AimTo estimate the prevalence and examine demographic correlates of CSB among gay men in the United States.MethodsA U.S. national probability sample of 227 gay-identified men were collected as part of the 2015 National Survey of Sexual Health and Behavior (NSSHB).OutcomesParticipants completed the Compulsive Sexual Behavior Inventory (CSBI-13) and demographic measures.RESULTSEighteen participants (7.93%) scored above the CSBI-13 clinical cut point, indicating they would likely meet criteria for clinically significant compulsive sexual behavior. To assess demographic correlates of CSB, demographic variables were entered into a logistic regression. Results of the logistic regression indicated that participant age, education, and religious affiliation were significant predictors of CSB status. Individuals scoring above the cut point were younger on average (M = 39.17; SD = 14.84) than those scoring below the cut point (M = 47.52; SD = 14.62; P = .02). Odds of scoring above the cut point were about six times greater for religiously affiliated participants compared to non-religiously affiliated participants (P = .005), and four times greater for those who had attended college compared to those who had not (P = .03).Clinical ImplicationsThese results indicate the prevalence of CSB in gay men is more modest than previously estimated, and is similar to the general population prevalence estimated in a previous study. The strongest predictor of CSB in this sample was religious affiliation, which underscores the importance of evaluating the role of religiosity in the etiology and/or identification of this clinical syndrome.Strengths and LimitationsThese findings are strengthened by the national probability sampling methodology and the use of the empirically validated CSBI-13 cut point. However, this sample was also older and had higher income and educational attainment than the larger population of gay men in the U.S.CONCLUSIONThese results indicate gay men may have a CSB prevalence rate similar to the general population, which contradicts previous research suggesting they are at greater risk for CSB.
Gendered access to land and household food insecurity: Evidence from Nigeria
Authors: Nnaji Amaka , Ratna Nazmun N. , Renwick Alan 
Published: August 2021

AbstractIn this article, we examine the joint influence of land access and gender of household head on household food insecurity by employing a logit model and using data from the 2015/2016 Nigerian General Household Survey. Our results show that female-headed households (FHHs) are more food insecure than male-headed households. However, with a 1-acre increase in their access to land, FHHs are 16 percent less likely to be food insecure. This finding provides policy insights into how improving access to arable land for land-poor FHHs can enhance food security in Nigeria.
Sodium Valproate Versus Dopamine Antagonists for Acute Migraine in the Emergency Department: A Systematic Review
Authors: Viau J. Alexander , Patel Dilan , Cheng Wei , Cortel-LeBlanc Miguel , Nath Avik , Perry Jeffrey J. 
Published: August 2021

ABSTRACT:Background:Migraine is a common primary headache disorder diagnosed in the emergency department (ED). This systematic review sought to compare the efficacy of sodium valproate (SV) to dopamine antagonists (DA) in relieving pain due to acute migraine.Methods:Two research librarians helped create a search strategy including Embase, Ovid Medline, and the Cochrane Database of Clinical Trials from inception to June 1, 2020, updated May 19, 2021. Two investigators identified randomized control trials (RCTs) including adult patients with acute migraine presenting to the ED or acute clinical setting comparing SV to a DA with the aim of relieving pain. Primary outcome was headache relief at 1 hour from treatment. Secondary outcomes included pain relief at 24 hours, relief of associated symptoms (e.g. nausea, photo-/phonophobia, etc.), and need for rescue analgesia. Meta-analysis was performed and presented as odds ratios.Results:Four RCTs with 470 patients were identified from an initial pool of 454 titles. Two studies compared SV to a DA alone and two compared SV to a DA plus one other agent (sumatriptan or dihydroergotamine). Three studies were included for meta-analysis. Pain relief had a pooled odds ratio of 1.14 at 1 hour and 0.42 at 24 hours. Three articles reporting the need for rescue analgesia had pooled odds ratio of 2.76.Conclusions:Sodium valproate is not more effective than DA at reducing migraine headache pain at 1 hour and less effective at 24 hours. Dopamine antagonists should be used over SV for the management of patients with acute migraine.
A redescription ofStenoporaand the type speciesStenopora tasmaniensisLonsdale, 1844 (Trepostomata, Bryozoa)
Authors: Reid Catherine M. 
Published: August 2021

AbstractType material forStenopora tasmaniensisLonsdale, 1844 was lost in the late nineteenth century, and subsequent descriptions of the genus have been based on material incorrectly assigned to the type species. A neotype is erected forS. tasmaniensisfrom the original type locality and the genus redescribed. The genus exhibits ramose, frondescent, encrusting, and massive colony morphologies, diaphragms are absent, and acanthostyles of a single size surround each aperture. This single size of acanthostyles aligns with the original type species description; however, it differs from the subsequently accepted genus description and may result in existing species being removed from the genus. Analysis of zooecial characters of a single colony exhibiting both frondescent and ramose morphologies reveals statistically significant differences between subsampled sections, despite being from the same colony. Differences relate to details of zooecial parameters and are not controlled by colony morphology. This variation within a single colony confirms the importance of using qualitative characters alongside quantitative measures in defining Paleozoic bryozoan species.
SOME QUESTIONS OF UNIFORMITY IN ALGORITHMIC RANDOMNESS
Authors: BIENVENU LAURENT , CSIMA BARBARA F. , HARRISON-TRAINOR MATTHEW 
Published: August 2021

AbstractThe
$\Omega $
numbers—the halting probabilities of universal prefix-free machines—are known to be exactly the Martin-Löf random left-c.e. reals. We show that one cannot uniformly produce, from a Martin-Löf random left-c.e. real
$\alpha $
, a universal prefix-free machine U whose halting probability is
$\alpha $
. We also answer a question of Barmpalias and Lewis-Pye by showing that given a left-c.e. real
$\alpha $
, one cannot uniformly produce a left-c.e. real
$\beta $
such that
$\alpha - \beta $
is neither left-c.e. nor right-c.e.
Prospective association of confectionery intake with depressive symptoms among Japanese workers: the Furukawa Nutrition and Health Study
Authors: Shimmura Nao , Nanri Akiko , Kashino Ikuko , Kochi Takeshi , Eguchi Masafumi , Kabe Isamu , Mizoue Tetsuya 
Published: August 2021

AbstractHigh intake of sweet foods such as cakes, cookies, chocolate and ice cream has been reported to be associated with depressive symptoms. However, prospective studies are scarce and no study has been conducted in Asian populations. We prospectively investigated the association between confectionery intake and depressive symptoms in a Japanese working population. Participants were 911 workers (812 men and 99 women; aged 19–68 years) without depressive symptoms at baseline who completed a 3-year follow-up survey. Dietary intake was assessed using a validated self-administered diet history questionnaire. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple logistic regression was used to estimate the OR of depressive symptoms according to tertile of confectionery intake with adjustment for covariates. At the time of the 3-year follow-up survey, 153 (16·8 %) workers were newly identified as having depressive symptoms (CES-D score ≥ 16). Confectionery intake was significantly associated with increased odds of developing depressive symptoms. The multivariable-adjusted OR of depressive symptoms for the highest v. lowest tertile of confectionery intake was 1·72 (95 % CI 1·03, 2·86) after adjustment for covariates including dietary factors such as folate, vitamin B6, vitamin B12, n-3 PUFA, Mg, Zn and soft drink (Pfor trend = 0·012). Our results suggest that confectionery intake is associated with a higher risk of depressive symptoms in a Japanese working population predominantly comprised of men.
Policy Ideology and Local Ideological Representation in Canada
Authors: Lucas Jack , Armstrong David A. 
Published: August 2021

AbstractTo enable new research on local ideology and representation in Canada, we construct a latent measure of the policy ideology of 37,500 Canadian Election Study respondents using 56 policy-relevant questions and then use multilevel regression and poststratification to estimate the average ideological position of each of Canada's 338 federal electoral districts and 250 largest municipalities. We use these local ideology estimates to examine ideological representation in Canadian municipal politics. Combining our municipal ideology estimates with elite survey data from more than 900 Canadian municipal politicians, we find evidence of a strong relationship between mass and elite ideology. This relationship is consistent across differing municipal population sizes and institutional structures. We conclude with additional detail on our publicly available individual and aggregate measures and describe their potential uses for future research on ideology and representation in Canadian politics at all levels.
Milk metabolites, proteins and oxidative stress markers in dairy cows suffering from Staphylococcus aureus subclinical mastitis with or without spontaneous cure
Authors: Tabatabaee Nasim , Heidarpour Mohammad , Khoramian Babak 
Published: August 2021

AbstractOur objective was to evaluate relationships between milk components (acute phase proteins, enzymes, metabolic parameters and oxidative indices) and the spontaneous cure outcome of Staphylococcus aureus subclinical mastitis in dairy cows. The values of haptoglobin, serum amyloid A (SAA), malondialdehyde (MDA), total antioxidant capacity, milk urea nitrogen (MUN), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), electrolytes (Cl and K), total protein, albumin, α-lactalbumin, β-lactoglobulin, and immunoglobulin were measured in milk samples of S. aureus subclinical mastitis cows with spontaneous cure (n = 23), S. aureus subclinical mastitis cows without spontaneous cure (n = 29) and healthy cows (n = 23). The comparison of measured parameters revealed that subclinical mastitis cows with spontaneous cure had lower ALP and haptoglobin concentrations both at diagnosis and after cure (P < 0.05). In contrast, total antioxidant capacity and MDA concentration in subclinical mastitis cows without spontaneous cure significantly increased with time (P < 0.05). We can suggest that elevated haptoglobin concentration and higher ALP activity indicative of enhanced oxidative stress could potentially serve as early diagnostic indicators of chronic disease and the persistence of S. aureus subclinical mastitis in dairy cows.
First description of aRaphidascarisspecies (Nematoda: Raphidascarididae) in a mudskipperApocryptes bato(Actinopterygii: Gobiidae) from West Bengal, India
Authors: Patra B.K. , Choudhury A. , Thorn R. , Ash A. 
Published: August 2021

AbstractA new nematode species,Raphidascaris mundeswariensisn. sp. (Raphidascarididae), is described from male and female specimens found in the intestines of the mudskipperApocryptes bato(Hamilton, 1822) (Gobiidae) from the Mundeswari River of West Bengal, India. This species is distinguished from its congeners by 214–255-μm-long spicules, 14 pairs of preanal papillae of two markedly different sizes, one pair of adanal papillae, six pairs of postanal papillae and the absence of lateral alae. Phylogenetic analyses using partial sequences of the 28S ribosomal RNA gene place the new species in a clade containingRaphidascaris gigi,Raphidascaris lophii,Raphidascaris longispiculaand two species ofHysterothylacium. The molecular analyses also corroborate results of previous studies that have foundRaphidascarisandHysterothylaciumto be paraphyletic. The finding ofR.mundeswariensisinA.batois the firstRaphidascarisspecies described from a mudskipper anywhere.