bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Antimicrobial Screening of Some Novel 5-Substituted-1,10b-dihydroimidazole[1,2-c]quinazoline Derivatives
Authors: Rabari Haribhai , Vankar Hetal , Prajapati Beenkumar 
Published: May 2021

The emergence of multidrug microbial resistance is the main challenges that the modern scientists have so far been facing in the recent era. In this respect, new series of drug classes having potential to give antimicrobial effect have been synthesized. A new series of 5- substituted-1,10 b-dihydroimidazole[1,2-c]quinazoline derivatives 8a-e have been synthesized and screened for antibacterial activity and antifungal activity. Synthesized derivatives were characterized by IR, MASS and 1H-NMR spectroscopy. Synthesized compounds show good activity, which was comparable to the standard drug and it can be useful for the further clinical study. Antibacterial activity was evaluated against four different pathogenic bacterial strains like Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudo-monas aeruginosa. Among the screened compounds, 8e show good antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC of 50 and 100 μg/ml respectively. Antifungal activity was evaluated against two strains of fungi. Among the synthesized derivates, compound 8c was emerged out as the potent antifungal compound against Candida albicans and Aspergillus niger with MIC of 25 μg/ml and 75μg/ml respectively. Compound 8e also shows good antifungal activity with MIC of 50 μg/ml against both Candida albicans and Aspergillus niger. The overall results of this study indicated that synthesized quinazoline derivatives had the potential to act as an antibacterial and antifungal agent, hence further investigation is warranted.
Chemometrics and Monte-Carlo Simulation Assisted RP-LC Method for Estimation of Cinacalcet Hydro- chloride in Pharmaceutical Products
Authors: Bera Ravi Kumar Venkata Varaha , Panda Sagar Suman 
Published: May 2021

Cinacalcet hydrochloride (CNT) is a novel calcimimetic agent widely used in the treatment of hyperparathy- roidism. For the first time, the authors utilized the novel concept of analytical procedure development employing several unique scientific tools for quantification CNT from its pharmaceutical dosage form. The objective behind the present work was to establish a scientifically sound and systematic work frame that overcomes the drawbacks of the earlier reported method for estimating CNT level in samples and ensuring superior method performance throughout the analytical life-cycle. In this process, at first, the risky method variables were earmarked and were subjected to a response surface methodology, followed by Monte-Carlo simulation (MCS) based robust- ness-cum-optimization studies. The inclusion of the MCS approach assessed the method performance with no additional laboratory experimentation and established the innovative hyphenation's aptness with chemometrics tools. The control strategies were established based on analytical design space and method performance evaluation results by a simulative approach. The study revealed that methanol %, flow rate, and pH are the three critical method variables influencing analytical attributes: retention time, the number of plates, and tailing. The analytical conditions include a C18 column (150mm × 4.6mm, 5μm) with an isocratic mobile phase (80:20, % v/v) of methanol and 0.01M KH2PO4 buffer (pH maintained at 3.5 using orthophosphoric acid) flowing at 1.1ml/min. Diode array detection was performed at 282 nm. Method validation was befitting to federal needs as linearity (0.5-160 μg/ml), accuracy (>99%), and precision below 1% of relative standard deviation are indicative of method suitability for the purpose. In a nutshell, the present method describes a typical analytical workflow with the significant advantage of obtaining more excellent scientific information with less systematized experimentation. It was found suitable for routine quality control of CNT in drug substance and drug product.
Mitos Dan Religi Dalam ‘Geguritan I Dukuh Siladri’ Karya Sastra Kreatif Dan Dinamis
Authors: Sri Yudari A.A. Kade , Paramita I Gusti Agung , Ngurah I Gusti Ayu 
Published: May 2021

This article is a small part of research report on the oral tradition of ‘Nyurud di Setra’ in the Klungkung-Bali Pakraman community Village Pemenang. One of the subsections reveals the relationship between myth and religion towards the traditional inherentance of Pura Dalem Suladri which is implicitly described in ‘geguritan I Dukuh Siladri’. With the qualitative interpretative descriptive methods, it is understood that religion is one elements of universal culture which containts of beliefs and behavior related to supernatural power and powers. Meanwhile, myth is an important part of human life as a psychological necessity due to woory and fear of the wrath universe. In order for humans to avoid disaster, sacred and sacred stories are about objects that govern the universe are built, strengthened by sacred buildings and religious rituals. Thus, the‘geguritan I Dukuh Siladri’ appears to be a creative and dynamic literary work following the reality cummunity of social life according to the time.
Memorisation and implicit perceptual learning are enhanced for preferred musical intervals and chords
Authors: Sarasso Pietro , Perna Pasqualina , Barbieri Paolo , Neppi-Modona Marco , Sacco Katiuscia , Ronga Irene 
Published: May 2021

AbstractIs it true that we learn better what we like? Current neuroaesthetic and neurocomputational models of aesthetic appreciation postulate the existence of a correlation between aesthetic appreciation and learning. However, even though aesthetic appreciation has been associated with attentional enhancements, systematic evidence demonstrating its influence on learning processes is still lacking. Here, in two experiments, we investigated the relationship between aesthetic preferences for consonance versus dissonance and the memorisation of musical intervals and chords. In Experiment 1, 60 participants were first asked to memorise and evaluate arpeggiated triad chords (memorisation phase), then, following a distraction task, chords’ memorisation accuracy was measured (recognition phase). Memorisation resulted to be significantly enhanced for subjectively preferred as compared with non-preferred chords. To explore the possible neural mechanisms underlying these results, we performed an EEG study, directed to investigate implicit perceptual learning dynamics (Experiment 2). Through an auditory mismatch detection paradigm, electrophysiological responses to standard/deviant intervals were recorded, while participants were asked to evaluate the beauty of the intervals. We found a significant trial-by-trial correlation between subjective aesthetic judgements and single trial amplitude fluctuations of the ERP attention-related N1 component. Moreover, implicit perceptual learning, expressed by larger mismatch detection responses, was enhanced for more appreciated intervals. Altogether, our results showed the existence of a relationship between aesthetic appreciation and implicit learning dynamics as well as higher-order learning processes, such as memorisation. This finding might suggest possible future applications in different research domains such as teaching and rehabilitation of memory and attentional deficits.
Pengaruh Profitabilitas Terhadap Agresivitas Pajak Dengan Capital Intensity Sebagai Variabel Moderasi
Authors: Mustofa Muhamad Apep , Amini Maryam , Djaddang Syahril 
Published: May 2021

Penelitian ini bertujuan untuk menguji pengaruh profitabilitas terhadap agresivitas pajak dan pengaruh profitabilitas terhadap agresivitas pajak dengan capital intensity sebagai variabel moderasi.
Populasi yang digunakan dalam penelitian ini adalah perusahaan industri pertambangan batu bara yang telah terdaftar di Bursa Efek Indonesia tahun 2014-2018. Peneliti menggunakan metode purposive sampling dengan total sampel 40 sampel dari 17 perusahaan yang telah terpilih.
Hasil penelitian menujukkan bahwa capital intensity dapat memoderasi pengaruh profitabilitas terhadap agresivitas pajak. Dan juga profitabilitas berpengaruh terhadap agresivitas pajak.
Kata kunci: Profitabilitas, Capital Intensity, dan Agresivitas Pajak
Learning Nonlocal Phonotactics in a Strictly Piecewise Probabilistic Phonotactic Model
Authors: Dai Huteng 
Published: May 2021

Phonotactic learning is a crucial aspect of phonological acquisition and has figured significantly in computational research in phonology (Prince & Tesar 2004). However, one persistent challenge for this line of research is inducing non-local co-occurrence patterns (Hayes & Wilson 2008). The current study develops a probabilistic phonotactic model based on the Strictly Piecewise class of subregular languages (Heinz 2010). The model successfully learns both segmental and featural representations, and correctly predicts the acceptabilities of the nonce forms in Quechua (Gouskova & Gallagher 2020).
On the Phonology and Semantics of Deaccentuation
Authors: Shapiro Naomi Tachikawa , Anttila Arto 
Published: May 2021

The deaccentuation of given and/or repeated elements is familiar from many dialects of English. We propose that deaccentuation is essentially an optional postlexical phonological process of stress retraction triggered by two constraints: *Stress-Copy, which assigns a violation to a stress peak on a word with a segmentally identical copy in the left context, and Rightmost, which assigns a violation to every word between a stress peak and the right phrase edge. We quantify deaccentuation by defining it as being perceived with less stress than expected, where expected stress is calculated by an implementation of Liberman and Prince's (1977) phrasal stress algorithm. We provide empirical evidence for our analysis based on the first inaugurals of six former U.S. presidents.
WHEN TIME FLIES: STATE AND TRAIT BOREDOM, TIME PERCEPTION, AND HEDONIC TASK APPRAISALS
Authors: Weiss Emily R. , Todman McWelling , Pazar Özge , Mullens Sophia , Maurer Kristin , Romano Alexandra C. 
Published: May 2021

An abundance of empirical research has established that a robust, positive association exists between feelings of boredom and the illusion of temporal slowing. Although state and trait forms of boredom are distinct constructs, the way these variables interact with one another to impact time perception is unknown. To further explore the association between boredom and time perception, a modified replication of a study that examined the impact of discrepancies between expected and perceived time progression on hedonic appraisals was conducted. The paradigm was extended through the inclusion of validated measures of trait and recent state boredom. Seventy-two participants (N = 72, aged 18-52, M = 23.06, SD = 5.73) were led to believe that they would perform an intrinsically unengaging task for 5 (Time Drags), 10 (Real Time), or 15 minutes (Time Flies). Consistent with previous findings, participants in the Time Drags condition reported time as progressing significantly slower than participants in the other two conditions. Moreover, participants in the Time Drags condition rated the task as significantly more aversive than did participants in the Time Flies condition. This association remained significant even when controlling for levels of trait and recent state boredom. However, the Real Time and Time Flies conditions did not differ from one another in terms of task ratings or perceived time progression. Implications of these findings and directions for future research are discussed.
TINGKAT PENGETAHUAN ORANG TUA TENTANG COVID-19 DI RUANG RAWAT INAP PEDIATRIK RUMAH SAKIT ADVENT BANDUNG
Authors: Simbolon Nani 
Published: May 2021

ABSTRACT

Coronavirus Disease (COVID-19) is a pandemic disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and World Health Organization shows the increase number of confirmed cases from various countries massively. It is hoped that through good understanding and knowledge about COVID-19 from all elements of society it can form a behavior in accordance with the protocol and it can break the chain of transmission of the COVID-19 virus. This study aims to describe the level of knowledge about COVID-19 in pediatric’s parents at Bandung Adventist Hospital. This research design is descriptive quantitative, and the sample taken through purposive sampling with 50 people. The instrument used was a knowledge questionnaire about Covid-19. The result of this research found that the level of parents knowledge about COVID-19 is in the good category (84%).

Keywords: Knowledge, Coronavirus Disease

ABSTRAK

Coronavirus Disease 2019 (COVID-19) merupakan penyakit pandemi yang disebabkan oleh virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) dan data organisasi kesehatan dunia menunjukkan peningkatan jumlah kasus terkonfimasi dari berbagai negara secara masif. Diharapkan melalui pemahaman dan pengetahuan yang baik tentang COVID-19 dari seluruh elemen masyarakat dapat membentuk perilaku yang sesuai dengan protokol sehingga dapat memutuskan mata rantai penularan virus COVID-19. Penelitian ini bertujuan untuk melihat gambaran tingkat pengetahuan orang tua pasien pediatrik yang dirawat di Rumah Sakit Advent Bandung. Desain penelitian ini adalah kuantitatif deskriptif, dan jumlah sampel yang diambil menggunakan teknik total sampling adalah sebanyak 50 orang. Instrumen yang digunakan adalah kuesioner pengetahuan tentang Covid-19. Hasil penelitian ini memperoleh gambaran tingkat pengetahuan orang tua tentang COVID-19 berada dalam kategori yang baik (84%).
Korelasi Kecemasan dan Domain Kelelahan pada Pasien Tuberkulosis
Authors: Tasnim Tasnim , Lainsamputty Ferdy 
Published: May 2021

Tuberculosis (TB) is a major health problem in many countries worldwide, ranked at the same level as Human Immunodeficiency Virus (HIV). In patients with TB, anxiety comes from the worsening of disease that created feeling of distress and fatigue. This study aimed to examine the relationship between anxiety and fatigue domains among tuberculosis patients. This study used a descriptive correlation design with cross-sectional approach. Consecutive sampling technique was used to recruit 70 participants from a general hospital in Central Sulawesi Province, Indonesia. The questionnaires used were Hamilton Anxiety Rating Scale (HAM-A) and Multidimensional Assessment of fatigue (MAF). Descriptive statistics and Spearman Correlation used to examine the relationship between variables. Anxiety had a significant correlation with distress domain of fatigue (r = 0,24, p < 0,05). Those who experienced greater anxiety suffered more mental fatigue.
Tuberkulosis (TB) merupakan masalah kesehatan utama di berbagai negara di dunia, berada diperingkat sama dengan penyakit HIV yang mematikan. Kecemasan pada pasien TB bersumber dari progress memburuknya penyakit sehingga membuat pasien tertekan secara psikologis dan mengalami kelelahan. Penelitian ini bertujuan untuk mengetahui hubungan kecemasan dan domain kelelahan pada pasien tuberkulosis. Penelitian ini berjenis deskriptif korelasi dengan pendekatan potong lintang menggunakan 70 sampel, yang direkrut dengan teknik consecutive sampling dari salah satu rumah sakit umum daerah di Sulawesi Tengah. Kuesioner yang digunakan yaitu Hamilton Anxiety Rating Scale (HAM-A) dan Multidimensional Assessment of Fatigue (MAF). Statistik deskriptif dan korelasi Spearman digunakan untuk mencari hubungan antar variabel. Kecemasan memiiki korelasi yang siginifikan dengan domain tekanan kelelahan (r = 0,24, p < 0,05). Partisipan dengan kecemasan berat, menderita kelelahan mental yang lebih parah.
PENGGUNAAN METODE BENEISH RATIO DALAM PENDETEKSIAN KECURANGAN LAPORAN KEUANGAN
Authors: Murdihardjo Lukas , Nurjanah Yayuk , Sari Febriani Indah 
Published: May 2021

Penelitian ini bertujuan untuk mendeteksi kecurangan terhadap laporan keuangan dengan menggunakan Metode Beneish Rasio Indeks pada Perusahaan Subsektor Makanan dan Minuman yang Listing di Bursa Efek Indonesia. Data yang digunakan dalam penelitian ini adalah data sekunder periode 2015 sampai dengan 2019, yang diperoleh dari website www.idx.com dengan jumlah 12 sampel perusahaan subsektor makanan dan minuman untuk mengetahui perusahaan mana yang tergolong manipulator, non manipulator, dan grey company. Teknik pengambilan data menggunakan metode purposive sampling, dimana penulis hanya mengambil data- data yang sesuai dengan kriteria yang penulis inginkan. Penulis menggunakan teknik analsis data deskriptif kuantitatif dengan menggunakan Beneish Rasio Indeks. Berdasarkan penelitian , pendeteksian ini dapat diselesaikan dengan menggunakan 8 variabel Beneish Ratio Index yaitu DSRI, GMI, AQI, SGI, DEPI, SGAI, LVGI, dan TATA. Dimana hasil dari periode 2015 sampai dengan 2019 menunjukan bahwa ada 1 perusahaan yang terindikasi manipulator, 51 perusahaan non manipulator, dan 8 perusahaan grey company. Kata Kunci : Beneish Rasio Indeks, Kecurangan Laporan Keuangan, Kecurangan
Multiwavelength and Neutrino Emission from Blazar PKS 1502 + 106
Authors: Rodrigues Xavier , Garrappa Simone , Gao Shan , Paliya Vaidehi S. , Franckowiak Anna , Winter Walter 
Published: May 2021

Abstract
In 2019 July, the IceCube experiment detected a high-energy neutrino from the direction of the powerful blazar PKS 1502+106. We perform multiwavelength and multimessenger modeling of this source, using a fully selfconsistent one-zone model that includes the contribution of external radiation fields typical of flat-spectrum radio quasars. We identify three different activity states of the blazar: one quiescent state and two flaring states with hard and soft gamma-ray spectra. We find two hadronic models that can describe the multiwavelength emission during all three states: a leptohadronic model with a contribution from photohadronic processes to X-rays and gamma-rays, and a proton synchrotron model, where the emission from keV to 10 GeV comes from proton synchrotron radiation. Both models predict a substantial neutrino flux that is correlated with the gamma-ray and soft X-ray fluxes. Our results are compatible with the detection of a neutrino during the quiescent state, based on event rate statistics. We conclude that the soft X-ray spectra observed during bright flares strongly suggest a hadronic contribution, which can be interpreted as additional evidence for cosmic-ray acceleration in the source independently of neutrino observations. We find that more arguments can be made in favor of the leptohadronic model vis-a-vis the proton synchrotron scenario, such as a lower energetic demand during the quiescent state. However, the same leptohadronic model would be disfavored for flaring states of PKS 1502+106 if no IceCube events were found from the direction of the source before 2010, which would require an archival search.
Investigating Clumpy Galaxies in the Sloan Digital Sky Survey Stripe 82 Using the Galaxy Zoo
Authors: Mehta Vihang , Scarlata Claudia , Fortson Lucy , Dickinson Hugh , Adams Dominic , Chevallard Jacopo , Charlot Stéphane , Beck Melanie , Kruk Sandor , Simmons Brooke 
Published: May 2021

Abstract
Giant, star-forming clumps are a common feature prevalent among high-redshift star-forming galaxies and play a critical role in shaping their chaotic morphologies and yet, their nature and role in galaxy evolution remains to be fully understood. A majority of the effort to study clumps has been focused at high redshifts, and local clump studies have often suffered from small sample sizes. In this work, we present an analysis of clump properties in the local universe, and for the first time, performed with a statistically significant sample. With the help of the citizen science-powered Galaxy Zoo: Hubble project, we select a sample of 92 z < 0.06 clumpy galaxies in Sloan Digital Sky Survey Stripe 82 galaxies. Within this sample, we identify 543 clumps using a contrast-based image analysis algorithm and perform photometry as well as estimate their stellar population properties. The overall properties of our z < 0.06 clump sample are comparable to the high-redshift clumps. However, contrary to the high-redshift studies, we find no evidence of a gradient in clump ages or masses as a function of their galactocentric distances. Our results challenge the inward migration scenario for clump evolution for the local universe, potentially suggesting a larger contribution of ex situ clumps and/or longer clump migration timescales.
Observations of the Quiet Sun during the Deepest Solar Minimum of the Past Century with Chandrayaan-2 XSM: Elemental Abundances in the Quiescent Corona
Authors: Vadawale Santosh V. , Mondal Biswajit , Mithun N. P. S. , Sarkar Aveek , Janardhan P. , Joshi Bhuwan , Bhardwaj Anil , Shanmugam M. , Patel Arpit R. , Adalja Hitesh Kumar L. , Goyal Shiv Kumar , Ladiya Tinkal , Tiwari Neeraj Kumar , Singh Nishant , Kumar Sushil 
Published: May 2021

Abstract
Elements with low first ionization potential (FIP) are known to be 3–4 times more abundant in active region loops of the solar corona than in the photosphere. There have been observations suggesting that this observed “FIP bias” may be different in other parts of the solar corona and such observations are thus important in understanding the underlying mechanism. The Solar X-ray Monitor (XSM) on board the Chandrayaan-2 mission carried out spectroscopic observations of the Sun in soft X-rays during the 2019–2020 solar minimum, considered to be the quietest solar minimum of the past century. These observations provided a unique opportunity to study soft X-ray spectra of the quiescent solar corona in the absence of any active regions. By modeling high-resolution broadband X-ray spectra from XSM, we estimate the temperature and emission measure during periods of possibly the lowest solar X-ray intensity. We find that the derived parameters remain nearly constant over time with a temperature around 2 MK, suggesting the emission is dominated by X-ray bright points. We also obtain the abundances of Mg, Al, and Si relative to H, and find that the FIP bias is ∼2, lower than the values observed in active regions.
How Likely Are Snowball Episodes Near the Inner Edge of the Habitable Zone?
Authors: Wordsworth R. 
Published: May 2021

Abstract
Understanding when global glaciations occur on Earth-like planets is a major challenge in climate evolution research. Most models of how greenhouse gases like CO2 evolve with time on terrestrial planets are deterministic, but the complex, nonlinear nature of Earth’s climate history motivates study of nondeterministic climate models. Here a maximally simple stochastic model of CO2 evolution and climate on an Earth-like planet with an imperfect CO2 thermostat is investigated. It is shown that as stellar luminosity is increased in this model, the decrease in the average atmospheric CO2 concentration renders the climate increasingly unstable, with excursions to a low-temperature state common once the received stellar flux approaches that of present-day Earth. Unless climate feedbacks always force the variance in CO2 concentration to decline rapidly with received stellar flux, this means that terrestrial planets near the inner edge of the habitable zone may enter Snowball states quite frequently. Observations of the albedos and color variation of terrestrial-type exoplanets should allow this prediction to be tested directly in the future.