bluuebunny/crossref_metadata_2025_split huggingface dataset:
A contribuição das TICs para aumentar a credibilidade da imagem do destino. Estudo exploratório para o segmento de turismo acadêmico
Authors: Rodrigues Soares Jakson Renner 
Published: March 2021

A existência de estudantes internacionais em Galícia é uma situação cada vez mais evidente nas universidades galegas. Devido à competitividade existente não só entre destinos, mas também entre universidades, entender quais são os aspectos que influenciam na eleição do estudante, e saber como podemos influenciar na decisão desse turista é um ponto vital para a competitividade destes dois entes. Neste trabalho buscamos definir a mobilidade estudantil internacional como segmento turístico, além de propor variáveis que conformam a sua imagem. A pesquisa foi realizada segundo uma óptica qualitativa exploratória. Com ela se logrou identificar um conjunto de características do processo de formação da imagem. Aspectos afetivos e cognitivos que são considerados pelo turista acadêmico e que influem no seu comportamento de escolha do destino. Para chegar a esses resultados empiricamente, utilizou-se como métodos de coleta e análises dos dados a entrevista qualitativa e a análise de conteúdo, respectivamente. Dentre os resultados encontrados, cabe destacar a importância dada às informações orgânicas consultadas pelos entrevistados, que podem e devem ser consideradas pelos stakeholders de um destino que trabalhe com este segmento turístico.
Análisis turístico de Almadén (Ciudad Real). Propuestas de mejora en un entorno Patrimonio de la Humanidad
Authors: Azuara Grande Alberto , Del Río de la Hoz Isabel 
Published: March 2021

Venimos asistiendo en las últimas décadas a un incremento continuado de la importancia del turismo cultural tanto en nuestro país como en el resto de Europa, planteándose como un modelo alternativo al tradicional “turismo de sol y playa”. Este turismo “de interior” toma distintas posiciones dependiendo del destino a visitar, motivación del turista o tipo de oferta turística seleccionada, surgiendo así diferentes posibilidades de oferta turística, proporcionada a través de destinos de turismo cultural urbano, turismo de naturaleza o de turismo rural, a grandes rasgos. Estas formas de turismo no resultan independientes entre sí, y pueden mostrarse en combinación formando amplios espacios territoriales turísticos, pudiendo contener productos y elementos más innovadores como son el caso de las acciones de desarrollo del turismo cultural relacionado con la industria y la minería. En estos territorios se ha conseguido recuperar el patrimonio industrial y minero, acompañado de la implantación de oferta turística como elemento capaz de contribuir a desarrollar la zona. El caso de Almadén es paradigmático en España, debido a su reciente declaración como Patrimonio de la Humanidad, de ahí que sea necesario evaluar cuál es la situación en la que se encuentra actualmente el lugar, qué es lo que se ha venido haciendo hasta ahora, y en base a esto, qué debe realizarse en adelante desde la planificación y la gestión turística para continuar en el desarrollo y consolidación del destino, sin perder de vista los elementos de autenticidad e integridad recogidos por la UNESCO
Assessment of job satisfaction among community pharmacists in Baghdad, Iraq: a cross-sectional study
Authors: Ibrahim Inas R. , Ibrahim Mohamed I. , Majeed Ibrahim A. , Alkhafaje Zahraa 
Published: March 2021

Background: Pharmacists have the unique position of providing safe and effective care. Hence, addressing their feelings about their working life is crucial to provide good pharmacy services.
Objective: this study aimed to assess job satisfaction among Iraqi community pharmacists and determine the effect of pharmacist characteristics on job satisfaction.
Methods: A cross-sectional study was conducted among community pharmacists in Baghdad, the capital of Iraq. A simple random sample technique was adopted to select community pharmacists. A survey questionnaire using Warr-Cook-Wall satisfaction scale (ranging from extremely dissatisfied to extremely satisfied) was used to assess job satisfaction.
Results: Community pharmacists experienced moderate satisfaction with their jobs. The mean satisfaction score for all pharmacists was 20.4 (SD 3.7). The lowest mean scores occurred for recognition (1.4; SD 0.7), public respect (1.8; SD 0.9), and pharmacy regulations (1.9; SD 0.9). Job satisfaction was significantly affected by pharmacist characteristics, including gender (p<0.001), age (p<0.001), degree level (p=0.003), years in practice (p<0.001), working patterns (p< 0.001), and working hours (p<0.001). Regression analysis indicated pharmacist gender and age had the highest effect on job satisfaction, while, years in practice, working hours, and working pattern had the lowest effect.
Conclusions: Community pharmacists expressed moderate satisfaction with their jobs with satisfaction levels being affected by gender, age, years in practice, working patterns, and working hours. New strategies will require support for Iraqi pharmacists by the Ministry of Health and Syndicate of Iraqi Pharmacists before being included in extended pharmacy services.
NILAI TOLERANSI DALAM NOVEL “AYAT-AYAT CINTA 2” KARYA HABIBURRAHMAN EL-SHIRAZY
Authors: Kahfi Muhammad Rajul 
Published: March 2021

Penelitian ini dilatar belakangi oleh kepopuleran Novel Ayat-ayat Cinta 2 karya Habiburrahman El-Sirazhy yang menggambarkan harmonisasi antarumat beragama. Ayat-ayat Cinta 2 karya Habiburrahman El-Sirazhy merupakan salah satu karya sastra yang bersifat kompleks, unik dan tidak langsung dalam pengungkapannya masih memerlukan penjelasan yang tepat agar memberikan pemahaman yang sesuai tentang toleransi dan klasifikasinya. Penelitian dilakukan dengan metode deskripsi kualitatif terhadap Novel Aya-ayat Cinta 2 karya Habiburrahman El-Shirazhy dengan mendokumentasikan data yang terdapat dalam novel, mengolah data, dan menyusun hasil identifikasi serta menyimpulkan hasil data yang dianalisis secara keseluruhan dalam bentuk tulisan. Hasil penelitian diuraikan dengan memandang nilai-nilai toleransi pada Novel Ayat-ayat Cinta 2 karya Habiburrahman El-Shirazy sesuai dengan klasifikasi toleransi yaitu: kultural, suku, jenis kelamin, agama, dan sebagainya berdasarkan UUD 1945.
KEMAMPUAN MEMBACA KRITIS PESERTA DIDIK KELAS VIII SMP NEGERI 15 BANJARMASIN
Authors: Sapiah  , Jumadi  , Taqwiem Ahsani 
Published: March 2021

Tujuan penelitian, mendeskripsikan kemampuan, (a) mengingat dan mengenali fakta tersurat isi bacaan, (b) menginterpretasikan makna tersirat isi bacaan, (c) mengaplikasikan konsep isi bacaan, (d) menganalisis isi bacaan, (e) menyintesis isi bacaan, (f) menilai isi bacaan, dan (g) membaca kritis secara komprehensif peserta didik kelas VIII SMP Negeri 15 Banjarmasin. Jenis penelitian ini adalah penelitian kuantitatif dengan metode deskriptif. Pengambilan sampel menggunakan teknik sampling sederhana. Pangambilan sampel 25% dari pupolasi, yakni sebanyak 52 orang. Teknik pengumpulan data melalui tes.Teknik analisis data dilakukan dengan beberapa tahapan. Berdasarkan analisis hasil penelitian, yaitu kemampuan (a) mengingat dan mengenali fakta tersurat kategori baik, dengan nilai rata-rata 66,15. (b) menginterpretasikan makna tersirat kategori cukup, dengan nilai rata-rata 65. (c) mengaplikasikan konsep dikategorikan baik, dengan nilai rata-rata 66,53. (d) menganalisis dikategorikan baik, dengan nilai rata-rata 72,5. (e) menyintesis dikategorikan baik, dengan nilai rata-rata 75,19. (f) menilai isi bacaan, dikategorikan cukup, dengan nilai rata-rata 62,5. Untuk kemampuan membaca kritis secara komprehensif dikategorian baik, dengan nilai rata-rata 70,10.
Development Characteristics and Quantitative Prediction of Multiperiod Fractures in Superdeep Thrust-Fold Belt
Authors: Feng Jianwei , Qu Junxiao , Zhang Pengfei , Qin Feng 
Published: March 2021

Abstract
For a superdeep imbricated thrust-fold belt in the Kuqa depression of Tarim Basin, NW China, the structural fractures have a great impact on the tight gas reservoir productivity. In this research, structural fractures were characterized from core data and imaging logging data. Numerically, the finite element (FE) method was applied to simulate the 3-D paleotectonic stress field of the key fracture-generating period as well as the present-day stress field in the Keshen gas field. Based on previously developed geomechanical models, we further derived the models of fracture aperture and porosity under the palaeostress field. A fracture permeability model considering fracture filling degree and stress was developed based on the Fracture Seepage Theory. Finally, we obtained a series of calculation models for the present-day fracture aperture and permeability. The predictions based on these models agreed well with actual measurement results, with most of the relative errors less than 20%. The developed 3-D FE geomechanical model and fracture parameter prediction method hold great promise for characterizing fractures in other deep low-permeability reservoirs.
A New Effective Multiwalled Carbon Nanotube-Foam System for Mobility Control
Authors: Ramanathan Raja , Abdelwahab Omar , Nasr-El-Din Hisham A. 
Published: March 2021

SummaryNanoparticles have improved a surfactant's ability to create long-lasting foam. Recent studies have widely recommended the use of silica nanoparticles to enhance foam stability. This paper presents an experimental investigation of a new and highly effective alpha olefin sulfonate (AOS)–multiwalled carbon nanotube (MWCNT) system for mobility control during gas enhanced oil recovery (EOR) operations.The new AOS–MWCNT system was evaluated for its foam stability at 150°F using a high-pressure view cell. The MWCNT was obtained as solid particles of aspect ratio up to 100 and silica nanoparticles of median size of 118 nm. The foam system was optimized for its maximum half-life by varying the concentration of the AOS and the nanotube from 0.2 to 1% and 250 to 1,000 ppm, respectively. Compatibility testing with salts was done as well. Coreflood experiments with 1.5-in.-diameter, 6-in.-long Berea sandstone cores were run to calculate the mobility reduction factor at 150°F. Nitrogen foam was injected into the core at 80% foam quality in the tertiary recovery mode, and the pressure drop across the core was measured. The formation brine had a salinity of 5 wt% sodium chloride (NaCl), and the foaming solutions were prepared with 2 wt% NaCl.The optimal concentrations of the AOS solution and the nanotubes for maximum foam stability were determined to be 0.5% and 500 ppm, respectively. The optimized AOS–MWCNT system yielded 60% greater nitrogen foam half-life (32 minutes) than an optimized AOS–silica system at 150°F. The foam half-life of a stand-alone 0.5% AOS solution was 7 minutes. In the presence of crude oil, the foam half-life decreased for all the tested systems. Coreflood experiments at 150°F showed a significant increase in the mobility reduction factor when the new AOS–MWCNT system was used as the foamer instead of stand-alone AOS or AOS–silica system. The new foaming system was stable through the duration of the experiment, yielding foam in the effluent samples. There was no formation damage observed. Salt tolerance for the MWCNT nanofluid was higher than the silica nanofluid.Foam needs to be stable for long periods of time to ensure effective mobility control during gas injection for EOR. This paper investigates a new highly effective AOS-multiwalled carbon nanotube system that outperforms the AOS–silica foaming systems in terms of foam stability and mobility control at 150°F.
Assigning Secondary Structure in Proteins Using AI
Authors: Antony Jisna Vellara , Madhu Prayagh , Balakrishnan Jayaraj Pottekkattuvalappil 
Published: March 2021

Abstract
Knowledge about protein structure assignment enriches the structural and functional understanding of proteins. Accurate and reliable structure assignment data is crucial for secondary structure prediction systems. Since the '80s various methods based on hydrogen bond analysis and atomic coordinate geometry, followed by Machine Learning, have been employed in protein structure assignment. However, the assignment process becomes challenging when missing atoms are present in protein files. Our model develops a multi-class classifier program named DLFSA for assigning protein Secondary Structure Elements(SSE) using Convolutional Neural Networks(CNN). A fast and efficient GPU based parallel procedure extracts fragments from protein files. The model implemented in this work is trained with a subset of protein fragments and achieves 88.1% and 82.5% train and test accuracy, respectively. Our model uses only Cα coordinates for secondary structure assignments. The model is successfully tested on a few full-length proteins also. Results from the fragment-based studies demonstrate the feasibility of applying deep learning solutions for structure assignment problems.
Insisting on Life Dignity: Advance Care Planning in Taiwan During COVID-19 Pandemic
Authors: Yang Chun-Yi , Liu Ching-Nu , Yang Chi-Cheng , Tsai Zong-Dar , Lin Su-Fei , Lin Hsin-Yi , Huang Yen-Rong , Sun Fu-Min , Huang Feng-Chiao , Liu M.S Chia-Jen , Huang Tsun -Cheng , Huang Sheng-Jean 
Published: March 2021

Abstract
Background:The coronavirus disease 2019 (COVID-19) outbreak is a global public health crisis that has affected the implementation of advance care planning (ACP) in Taiwan. The purpose of this study is to (1) confirm that COVID-19 significantly reduced public participation in ACP, (2) identify factors influencing the implementation of ACP during the COVID-19 pandemic and how they differ from those before the COVID-19 outbreak.Methods: An observational study from retrospective review of medical chart and clinical information.This is a hospital-based study to examine the characteristics of ACP implementation in Taiwan during COVID-19. A total of 1,253 participants were recruited, including 916 people who had completed ACP from September through December 2019, and 337 people from January through April 2020.Results:This study representing an approximately 65% decrease in ACP participation after COVID-19 outbreak. The cancellation rate of ACP during COVID-19 is higher before outbreak. After COVID-19 outbreak, Participation rate of disadvantaged populations increased from 16.92% to 21.66%. The percentage of participants with caregiver experiences decreased from 31.66%to to 23.44% . Participants who did not wish for their families to bear decision-making responsibilities increased from 44.00% to 52.52%. The percentage of offspring participation increased from 86.57% to 90.80%. The percentage of individuals completing ACP after the outbreak without signing an advance directive increased from 5.57% to 9.20%. The COVID-19 pandemic significantly reduced participation in ACP. Conclusions: This study directly compared the ACP implementation before and after COVID-19, which is a tremendous global health crisis influencing the conceptions of life and death.COVID-19 has threatened the public’s health and has changed ACP in the healthcare system by increasing public awareness of the topic of death. After COVID-19, both medical staff and the public should clearly express their opinions on terminal care.Policy supports and active participation of medical team can encourage disadvantages to complete ACP.Healthcare workers should provide palliative and terminal care services in which patient comfort and dignity are the primary focus of care.Trial registration:This study was approved on 3 June 2020 by the Taipei City Hospital Institutional Review Board (Case No.: TCHIRB-10808008-E).
Management of Chronic Noninfectious Uveitis with Low-Dose Methotrexate
Authors: Kim Yong-Hui , Ko Mi-Ryong , Ryu Kang-Chol , Kang Il-Hyok 
Published: March 2021

Abstract
Purpose

To evaluate the effectiveness of low-dose oral methotrexate(5mg/week) among chronic noninfectious uveitis patients who were unresponsive to conventional steroids therapy.
Methods

27 patients with chronic noninfectious uveitis who were treated with low-dose methotrexate (MTX) at ophthalmology department of Pyongyang University of Medical Science Hospital from 2017 to 2020 were participated in this study.Each patient received oral MTX at dose of 5mg/week except that 2 patients were given 7.5mg/week MTX for the first 4 weeks. The treatment effects were evaluated based on ratio of inflammation control, Log MAR visual acuity, mean number of relapses and steroid-sparing effect. Every adverse effect associated with drug use was recorded.
Results

Control of inflammation was achieved in 92.6% of patients. Visual acuity was improved in 82.9% (29 eyes among 35 eyes) and maintained in 5.7% (2 eyes). The mean number of relapses was decreased from 4.2 (before therapy) to 1.9 (after therapy). Steroid-sparing effect was achieved in 85.2% patients. There was no serious side effect requiring discontinuation of therapy but some adverse reactions were recorded in 22.2% of patients.
Conclusions

Low-dose methotrexate(5mg/week) is supposed to be able to successfully control chronic noninfectious uveitis and has a steroid-sparing effect. It is also safer because it shows less adverse effects.
Deregulation of miR-34a, miR-221 and miR-222 after HT29 cells treatment with Silibinin encapsulated in polymersomes as an anti-cancer stem cell agent
Authors: Hosseinzadeh Samaneh , Pakizehkar Safura , Ranji Najmeh , Sohi Alireza Naderi , Najafi Farhood 
Published: March 2021

Abstract
Colorectal Cancer (CRC) has the most common malignant gastrointestinal cancer which representing about13% of all malignant tumor. CRC Cancer Stem Cell is the major reasons for recurrence of disease cause of solid tumor metastasis, relapse of cancer after treatment and drug resistance. Silibinin, an herbal extract from milk thistle plant, has been identified as a potential cancer medicine that can target the signaling pathway of CSCs and change their abilities. In our study, the results of CSC confirmation test such as specific surface CD markers and ability to form colonospheres was indicated the HT-29 cells as CSC-CRC. To increase the effectiveness of Silibinin, and also, to evaluate therapeutic intentions on HT-29 cancer stem-like cells, we encapsulated Silibinin in polymersome nanoparticle and validated the anti-proliferative and apoptotic activities of this new patent by MTT assay, AnnexinV/PI method, cell cycle analysis and DAPI staining. Furthermore, the efficacy of drug on Multicellular Tumor Spheroid (MCTS) and single cell suspension was showed that SPN had succeed to decrees the expression level of CSC CD markers compared with control group. Follow by using miRNAs as a novel and minus invasive expertise for prognostic, RT-qPCR confirmed that SPNs can repress oncogenic miRNAs such as miR-221 and miR-222. Silibinin encapsulated in Polymersome Nanoparticles (SPNs) can also enhance the expression of tumor suppressor miR-34a and some of its proapoptotic target genes such as P53, BAX, CASP9, CASP3, and CASP8. Our results suggested that SPNs can be recognized as a new stimulant factor to direct the HT-29 cancer cells toward apoptosis pathways thorough modify expression of some miRNAs and their apoptotic target genes directly and/or indirectly.
Antecedent water condition determines carbon exchange response to extreme precipitation events across global drylands
Authors: Zhao Huichen , Xu Xiyan , Jia Gensuo , Zhang Anzhi , Wang Hesong 
Published: March 2021

Abstract
The global hydrological cycle is predicted to be intensified under the warming climate, with more extreme precipitation events and longer dry spell in between. Here, we evaluated how extreme precipitation events (EPEs) with antecedent dry (dry-EPEs) and wet (wet-EPEs) water conditions influence carbon exchange along gradient of arid, semi-arid and sub-humid ecosystems based on eddy covariance datasets. After EPEs, ecosystem respiration (Re) and gross primary productivity (GPP) were stimulated by pulses of soil moisture in arid and semi-arid regions, but suppressed by decreased soil temperature in sub-humid region. Antecedent water condition determined asynchronous response of Re and GPP to EPEs, and therefore fluctuations in net carbon balance. Net carbon uptake capacity was enhanced immediately following wet-EPEs because of more rapid and greater response of GPP than Re. However, after dry-EPEs, net carbon uptake capacity decreased immediately and increased thereafter because the response of GPP to dry-EPEs lagged behind Re. More antecedent precipitation further stimulated accumulative net carbon uptake. Along the aridity gradient, duration and magnitude of net carbon release were greater in wetter regions than that in drier regions after dry-EPEs, while net carbon uptake duration was shorter in wetter regions after wet-EPEs. The accumulative net carbon uptake after EPEs decreased with increasing aridity index, indicating that net carbon uptake capacity in drier regions benefited more from EPEs. We concluded that antecedent water conditions and local climate regimes need to be considered when interpreting the response of carbon exchange to EPEs in dryland ecosystems.
A retrospective investigation of twenty-five cases with periocular pilomatrixoma
Authors: Song Wei , Ma Zhenyi 
Published: March 2021

Abstract
Purpose

Pilomatrixoma is an uncommon benign skin tumor, developing from hair follicle matrix. It consistently presents in the head and neck region patients with pediatric predominance, from infancy to senior. Thus far, few case series studies have been focused on the periocular lesions that involve the eyelid and eyebrow. In the present study, we carried out a case series with 25 patients of periocular pilomatrixoma.
Methods

Records from the Hospital Information System (HIS) of our hospital were reviewed retrospectively between the years 2009 and 2020 to search for all patients that were diagnosed as pilomatrixoma of eyelid or eyebrow. All patients received excision in the Department of Ophthalmology and histological examinations in the Department of Pathology. Patients’ information and characterization of tumors features were recorded and analyzed.
Results

These clinical conditions were mostly found in female patients in their early twenties. All tumors developed at upper eyelids or eyebrows and both right and left sides were equally affected. Basophilic cells and shadow cells were the basic components of the lesions, with or without calcification and foreign body giant cells. Complete surgical resection was the essential therapeutical approach for this disease and no recurrence or malignant transformations were noticed upon follow-up.
Conclusion

The findings of current case series analysis are in concordance with the clinical and histopathological features of periocular pilomatrixoma.