bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does tourism increase CO2 emissions and health spending in Mexico? New evidence from nonlinear ARDL approach
Authors: Fan Yongxian , Ullah Irfan , Rehman Alam , Hussain Arif , Zeeshan Muhammad 
Published: September 2021

AbstractThis study investigates the nexus between tourism, CO2 emissions and health spending in Mexico. We applied a nonlinear ARDL approach for the empirical analysis for the time period 1996–2018. Mexico receives a large number of tourists each year, tourism improves foreign exchange earnings and contributes positively to the economic growth. However, tourist activities impose a serious environmental cost in terms of CO2 emissions which increase health spending. The empirical findings suggest that tourism leads to CO2 emissions which resultantly causes a high level of health spending in Mexico. Both short‐run and long‐run findings reported a significant positive association between tourism, CO2 emissions, and health expenditures. Therefore, the government needs legislation to reduce CO2 emissions, besides the use of renewable energy could also help to reduce the CO2 emissions and health expenditures in society. This study does not support to reduce the health expenditure, rather it suggests optimal utilization of the funds allocated to the health sector.
Responsiveness of hospitals to inpatient and outpatient services in the low‐ and middle‐income countries: A systematic review
Authors: Shaqura Iyad Ibrahim , Jaafaripooyan Ebrahim , Ahmadi Batoul , Akbari Sari Ali 
Published: September 2021

AbstractResponsiveness is the ability of health system to satisfy non‐clinical people's expectations. This review aimed at assessing responsiveness of hospitals' services in the low‐ and middle‐income countries, and identifying the influencing factors. This systematic review followed the PRISMA guidelines. PubMed, Scopus, Web of Science and ProQuest were searched. Studies of all designs aiming to assess responsiveness of hospitals' services in the period from 2005 up to the end of 2018 were included. Quality was appraised based on McMaster University tool. Results were presented as a narrative review. Fifteen studies originated from five low‐middle‐ income countries have been included. Results have been proposed under five subtopics; level and distribution of responsiveness and its domains at hospitals, rank of domains according to the participants, and factors affecting responsiveness and its related domains. Most studies have focused on responsiveness level, but not the distribution. Socioeconomic status, organisational, systemic, and contextual factors have led to varied responsiveness, consequently, policymakers would benefit from these valuable results while planning for improving health system in order to accomplish its intrinsic goals. Further research is required in the low‐ and middle‐income countries other than the five included in this review. Using the World Health Organization questionnaires for measuring responsiveness is recommended, and the contextual variations should be considered.
Hepatitis C virus testing in a clinical HIV cohort in Ontario, Canada, 2000 to 2015
Authors: Moqueet Nasheed , Grewal Ramandip , Mazzulli Tony , Cooper Curtis , Gardner Sandra L. , Salit Irving E. , Kroch Abigail , Burchell Ann N. ,   OHTN Cohort Study Team
Published: September 2021

AbstractBackgroundHIV‐positive individuals may acquire HCV via injection drug use (IDU) and condomless anal sex. HIV care provides opportunities for HCV testing and cure with direct‐acting antiviral agents (DAAs).MethodsWe analyzed data from the Ontario HIV Treatment Network Cohort Study. Among those not HCV‐positive or diagnosed previously (n = 4586), we used Cox regression to test the rates of ever HCV testing (serological or RNA) in HIV care by DAA era (pre‐DAA: 2000‐2010; after DAA: 2011‐2015) and compared the proportion diagnosed with HCV. We identified correlates of annual proportions of serological testing using Poisson generalized estimating equations.ResultsAfter DAA vs pre‐DAA, the hazard rate ratio (95% CI) of ever HCV testing was 1.70 (1.59, 1.81). The proportion (95% CI) tested annually increased from 9.2% (8.0%, 10.7%) in 2000 to 39.1% (37.1%, 41.1%) in 2015 (P < 0.0001). The proportion diagnosed with HCV declined by 74% pre‐DAA to 11% after DAAs. Annual testing increased per calendar year (16% steeper slope after DAA vs pre‐DAA) and was more common among men who have sex with men; those more educated (post‐secondary vs ≤ high school); and those positive for syphilis or reporting any IDU. Annual testing decreased per decade of age and time since HIV diagnosis.DiscussionAnnual HCV testing increased over time with higher testing among those reporting sexual or IDU risk factors, but fell short of clinical guidelines. Targeted interventions to boost testing may be needed to close these gaps and reach WHO 2030 HCV elimination targets.
Effect of digital elevation model spatial resolution on depression storage
Authors: Hou Jingming , Li Xinyi , Pan Zhanpeng , Wang Junhui , Wang Ruike 
Published: September 2021

AbstractSurface water storage—including wetlands and other small waterbodies—has largely been disregarded in traditional hydrological models. In this paper, the grid resampling method is adopted to study the influence of the digital elevation model (DEM) grid resolution on depression storage (DS) considering different rainfall return periods. It is observed that the DEM grid size highly affects DS, and the higher the grid resolution is, the larger the DS value. However, when the grid resolution reaches a certain value, the maximum DS value decreases. This suggests that a critical grid resolution value exists at which the water storage capacity of depressions is maximized, namely, 20 m in this work (except for the overall area simulation under infiltration). This phenomenon is further verified in two test cases with and without the infiltration process, that is, calculations of the local area and without infiltration area, respectively. This research may facilitate the accurate computation of the DS process, which is greatly affected by the grid resolution, thereby improving the reliability of hydrological models.
Ardières‐Morcille in the Beaujolais, France: A research catchment dedicated to study of the transport and impacts of diffuse agricultural pollution in rivers
Authors: Gouy Véronique , Liger Lucie , Ahrouch Samira , Bonnineau Chloé , Carluer Nadia , Chaumot Arnaud , Coquery Marina , Dabrin Aymeric , Margoum Christelle , Pesce Stéphane 
Published: September 2021

AbstractThe 8‐km2 Morcille catchment, which is a sub‐catchment of the 150‐km2 Ardières catchment in the Beaujolais region of France, is one of the first sites in Europe where research has been conducted on surface water contamination by pesticides. A consolidated hydrological and chemical dataset has been set up with data collected since 2002 on the Morcille River and since 2011 on the Ardières River. Additional data on the ecotoxicological and ecological impacts of pesticides on aquatic microbial communities and macroinvertebrates has also been recorded in both rivers since 2005. The ‘Site Atelier Ardières‐Morcille Dataset’ described here combines rainfall and stream water height measurements at gauged stations with concentrations of two trace elements and nine pesticides (mainly herbicides, fungicides and some of their metabolites) in both the Ardières and Morcille rivers. All contaminant concentration data showed spatial and temporal variability in water quality associated with pesticide use and rainfall patterns. This long‐term monitoring framework made it possible to estimate the persistence of two herbicides (diuron and norflurazon) after legislation banning them. It took 4 years for diuron and more than 10 years for norflurazon concentrations to fall below 0.1 μg/L. Concurrent biological data showed a gradient of impacts consistent with chemical anthropogenic pressure, and rapid recovery of phototrophic microbial communities after the diuron ban. Finally, monitoring data on pesticide transport in a grassed strip set on a slope of the Morcille catchment confirmed that vegetative filter strips can effectively reduce diuron fluxes in surface runoff (>80% abatement) and infiltration water (>70% abatement). The full dataset offers a valuable resource for the validation of hydrological models and the development of global approaches to better understand the pressure–transport–exposure–impact chain and aquatic community resilience at the small catchment scale.
Wnt pathway modulators in cancer therapeutics: An update on completed and ongoing clinical trials
Authors: Neiheisel Ann , Kaur Manpreet , Ma Nancy , Havard Patty , Shenoy Anitha K. 
Published: September 2021

AbstractWnt signaling plays an essential role in the initiation and progression of various types of cancer. Besides, the Wnt pathway components have been established as reliable biomarkers and potential targets for cancer therapy. Wnt signaling is categorized into canonical and noncanonical pathways. The canonical pathway is involved in cell survival, proliferation, differentiation and migration, while the noncanonical pathway regulates cell polarity and migration. Apart from its biological role in development and homeostasis, the Wnt pathway has been implicated in several pathological disorders, including cancer. As a result, inhibiting this pathway has been a focus of cancer research with multiple targetable candidates in development. In this review, our focus will be to summarize information about ongoing and completed clinical trials targeting various Wnt pathway components, along with describing current and emerging Wnt targeted therapies. In addition, we will discuss potential opportunities and associated challenges of inhibiting Wnt signaling for cancer therapy.
Low‐dose aspirin use and mortality risk in patients with head and neck cancer: A nationwide cohort study of 10 770 patients
Authors: de la Cour Cecilie D. , von Buchwald Christian , Dehlendorff Christian , Garset‐Zamani Martin , Grønhøj Christian , Carlander Amanda‐Louise F. , Friis Søren , Kjaer Susanne K. 
Published: September 2021

AbstractSeveral recent observational studies have linked low‐dose aspirin use to improved survival in patients with head and neck cancer. However, studies of patterns of aspirin use and risk of cancer‐specific mortality are lacking. This nationwide cohort study included all patients in the Danish Cancer Registry with a primary diagnosis of head and neck squamous cell cancer (HNSCC) during 2000 to 2016, aged 30 to 84 years, without prior cancer (except nonmelanoma skin cancer) and alive 1 year after diagnosis. Nationwide registries provided information on filled prescriptions, mortality and potential confounding factors. For a subpopulation, a clinical database provided additional information, including human papillomavirus (HPV) tumor status. We used Cox proportional hazards regression models to estimate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the association between postdiagnostic low‐dose aspirin use (≥1 prescription within first year after diagnosis) and risk of cancer‐specific mortality. We identified 10 770 patients with HNSCC during a median follow‐up of 3.9 years. Of these, 1799 (16.7%) were low‐dose aspirin users. Postdiagnostic use of low‐dose aspirin was associated with a HR of 0.97 (95% CI 0.82‐1.15) for cancer‐specific mortality. Similar neutral associations were found according to patterns of aspirin use. No apparent trends emerged according to age, sex, topography or stage. A tendency towards a decreased cancer‐specific mortality risk with low‐dose aspirin use was observed among HPV‐positive patients; however, the statistical precision was low. In conclusion, we did not observe an association between postdiagnostic low‐dose aspirin use and cancer‐specific mortality in a nationwide cohort of patients with HNSCC.
Childhood cancer drugs in China: An overview and comparison of regulatory approvals in China and the United States
Authors: Zhang Yichen , Katharina Wagner Anita , Du Haoxin , Han Taisen , Gupta Sumit , Denburg Avram E. , Frazier A. Lindsay , Guan Xiaodong , Shi Luwen 
Published: September 2021

AbstractDifferent from less developed countries, 80% of children with cancers in the United States are cured. Traditional chemotherapy drugs are the mainstay of therapies; new targeted medications have become available recently. Using publicly available data, we created a database of cancer drugs with paediatric malignancy indications approved by 31 October 2020 in China and the United States. We compared numbers, type, indications and listing on the World Health Organization Model List of Essential Medicines for Children (WHO EMLc) between the two countries, assessed the correlation between paediatric indications and cancer incidences, and described evidence supporting approvals of targeted medications in the two settings. Our study showed that by 31 October 2020, 31 and 39 cancer drugs available in China and the United States were approved for use in children, corresponding to 137 and 102 paediatric cancer indications, respectively. About half of these drugs (17 in China and 18 in the United States) were listed on the WHO EMLc. The correlation between indications and burden of disease was higher in the United States (r = 0.68) than China (r = 0.59). More traditional chemotherapy drugs were approved in China (n = 27) than the United States (n = 19). Of 20 targeted childhood anticancer medicines approved in the United States, mainly on the basis of single arm trials (27/32 indications, 84.4%), only four were approved for paediatric indications in China, at a median of 2.8 years after US Food and Drug Administration approval. A harmonised, evidence‐based regulatory framework is needed to ensure approvals of needed, safe and efficacious childhood cancer drugs across the world.
Pelvic inflammatory disease is associated with ovarian cancer development in women with endometriosis: A cohort study in Taiwan
Authors: Lo Hui‐Wen , Weng Shih‐Feng , Chen Hung‐Sheng , Tsai Eing‐Mei 
Published: September 2021

AbstractObjectiveEndometriosis and pelvic inflammatory disease are considered to be risk factors for ovarian cancer, as dysbiosis probably contributes to ovarian cancer development via chronic inflammation and immune response alteration. Therefore, we hypothesized that pelvic inflammatory disease predisposes to ovarian cancer development in women with endometriosis.MethodsWe selected patients who were diagnosed with endometriosis or pelvic inflammatory disease between January 1, 2000 and December 31, 2015, in a 2 million longitudinal health and welfare database in Taiwan with cancer and death registries. Patients were divided into five groups: (1) those with endometriosis, (2) those with pelvic inflammatory disease, (3) those with endometriosis diagnosed before pelvic inflammatory disease, (4) those with pelvic inflammatory disease diagnosed before endometriosis, and (5) healthy women. Propensity score matching with inverse probability of treatment weighting was used to adjust for covariates across the study groups.ResultsThe risk of ovarian cancer was significantly higher in women with endometriosis and subsequent pelvic inflammatory disease than in those with endometriosis alone (hazard ratio 8.07; 95% confidence interval 4.53–14.37; P < 0.001). The same result was found for ovarian cancer incidence per 1000 person‐years.ConclusionOur data show that pelvic inflammatory disease is associated with cancer development in women with pre‐existing endometriosis.
Observations and reports of incidents of how birthing persons are treated during childbirth in two public facilities in Argentina
Authors: Correa Malena , Klein Karen , Vasquez Paula , Williams Caitlin R. , Gibbons Luz , Cormick Gabriela , Belizan María 
Published: September 2021

AbstractObjectiveThis study sought to estimate the frequency and types of mistreatment during childbirth and explore health professionals’ opinions on barriers/facilitators to providing respectful childbirth care.MethodsThis prospective mixed‐methods investigation consisted of direct observations of childbirth (n = 250), at‐home surveys with birthing individuals (n = 45), and qualitative in‐depth health staff interviews (n = 6), conducted between January and July 2019, in two public facilities in Argentina. Frequencies of clinical practices and mistreatment and 5% confidence intervals were calculated. A logistic regression analysis was also conducted to examine associations between mistreatment and covariates of interest, with P < 0.05 considered statistically significant.ResultsOverall, 61/250 (24.4%, confidence interval 19.6%–30.6%) observations recorded instances of mistreatment; 20/45 surveyed participants (44.4%) reported at least one episode of mistreatment. The most frequent perpetrators were physicians (35.6%), birth companions (24.4%), midwives (22.2%), and nurses (13.3%). Participants with lower educational attainment and those racialized as non‐white had higher odds of being mistreated. Health providers reported that respectful childbirth is currently widely implemented due to authorities’ and communities’ awareness on respectful birth´s rights.ConclusionAlmost a quarter of birthing people were observed to suffer mistreatment – primarily verbal abuse – and 44.4% of surveyed individuals reported mistreatment. Future research is needed to determine how to ensure the provision of respectful childbirth care for all.A quarter of participants experienced mistreatment; mostly those with lower educational attainment and/or racialized as non‐white. Further research on implementation of respectful childbirth is warranted.
A case of pyelocalyceal diverticulum urothelial carcinoma that was difficult to distinguish from cystic renal cell carcinoma preoperatively
Authors: Matsuda Iori , Miyauchi Yasuyuki , Miura Takayoshi , Kato Takuma , Tsunemori Hiroyuki , Kimura Nachino , Miyai Yumi , Haba Reiji , Sugimoto Mikio 
Published: September 2021

IntroductionPyelocalyceal diverticulum is a rare disease sometimes difficult to distinguish from cysts. We report a case of urothelial carcinoma originating from a pyelocalyceal diverticulum, difficult to distinguish from cystic renal cell carcinoma preoperatively.Case presentationA 51‐year‐old Japanese man complained of gross hematuria. Computed tomography revealed a solid mass in one of the many cystic lesions in the left kidney. He was diagnosed with left cystic renal cell carcinoma and underwent retroperitoneal laparoscopic nephrectomy. Pathological examination revealed high‐grade invasive urothelial carcinoma arising within the renal pyelocalyceal diverticulum. The definitive diagnosis was high‐grade invasive urothelial carcinoma (pT3). In retrospect, the retrograde pyelography findings indicated the cyst and urinary tract connection. Residual ureterectomy and adjuvant chemotherapy were later performed. The patient has since been recurrence‐free.ConclusionWhether cystic renal cell carcinoma is suspected on imaging, pyelocalyceal diverticulum should be considered a differential diagnosis, though unlikely to be encountered in daily practice.
Hematopoietic progenitor cell counting can optimize peripheral blood stem cell apheresis process
Authors: Reberšek Katarina , Furlan Tadej , Zver Samo , Podgornik Helena 
Published: September 2021

AbstractIntroductionMonitoring of stem cell concentration in transplantation settings is crucial to determine the optimal time of apheresis and is currently based on enumeration of CD34+ cells by flow cytometry. No surrogate marker has replaced CD34+ cell enumeration to date. The aim of this study was the evaluation of the hematopoietic progenitor cell (HPC) parameter of the Sysmex XN‐1000 analyzer in terms of optimizing the peripheral blood stem cell apheresis process.Materials and MethodsResults of flow cytometric CD34+ cell and Sysmex HPC count were compared in 208 preharvest samples and 139 apheresis products.ResultsHPC and CD34+ cell counts showed significant differences in the multiple myeloma (MM) group. The correlation between preharvest HPC and CD34+ cell counts was good in the MM group (rho = .613) and strong in the lymphoma group (rho = .802), allogeneic donors (rho = .923), and other group of samples (rho = .816). The HPC positive cutoff demonstrating 100% specificity and positive predictive value for MM patients was high for ≥20/μL and ≥10/μL CD34+ cell counts, and therefore of limited value. The HPC negative cutoff demonstrating 100% sensitivity and negative predictive value was approximately <4/μL, irrespective of diagnosis.ConclusionsBased on proposed HPC positive cutoffs (≥31/μL in the lymphoma group and ≥11/μL in the other group of samples), routine HPC enumeration could improve the workflow by replacing CD34+ cell counting in allogeneic donors as well as non‐MM patients. Furthermore, based on proposed HPC negative cutoff (<4/μL), CD34+ cell counting could be fully omitted in donors and patients that are not adequately mobilized.
The relationship between problematic Internet use in adolescents and emotion regulation difficulty and family Internet attitude
Authors: Günaydın Nevin , Kaşko Arıcı Yeliz , Kutlu Fatma Y. , Yancar Demir Esra 
Published: September 2021

AbstractThe study aims to determine the relationship between problematic Internet use in adolescents and emotion regulation difficulty and family Internet attitude. The study used a descriptive and correlational design. The sample of the study consisted of 5916 students. The data were collected using the “Problematic Internet Use Scale,” “Difficulties in Emotion Regulation Scale,” “Internet Parental Style Scale.” The total score on the Problematic Internet Use Scale was 55.41 ± 19.60 while the total score on the Difficulties in Emotion Regulation Scale was 97.51 ± 17.84. Considering the Internet parental styles, it was found that 42.89% of the parents had a negligent attitude. According to the results of the logistic regression analysis performed, grade level was found to affect problematic Internet use. A highly significant correlation was found between problematic Internet use and emotional regulation difficulties and family control of family Internet attitude (p < 0.01). This study determined that adolescents' grade level and excessive Internet use of the father were effective in the problematic Internet use of the adolescents. Adolescents' difficulties in emotion regulation and the type of families' attitudes towards Internet use were associated with problematic Internet use. In accordance with these results, it can be recommended to form programs to decrease problematic Internet use.