bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social isolation, inflammation, and cancer mortality from the National Health and Nutrition Examination Survey - a study of 3,360 women
Authors: Koh-Bell Alexander , Chan Joshua , Mann Amandeep K. , Kapp Daniel S. 
Published: July 2021

Abstract
Background
This study evaluates the role of social isolation on inflammation and cancer mortality among women.

Methods
Data were abstracted from the U.S. National Health and Nutrition Examination Survey from 1988 to 1994. The Social Network Index was used to assess participants’ degree of social isolation. C-reactive protein and fibrinogen levels were included as markers of inflammation. We used the National Death Index to identify causes and dates of mortality. Chi-square and multivariable Cox regressions were employed for statistical analyses.

Results
Of 3360 women (median age: 54 years), the most isolated, very isolated, somewhat isolated, and not isolated comprised 14.5, 30.2, 37.1, and 18.2% of the sample, respectively. The most isolated participants were more likely to have low income (56.8% vs 12.2%, p < 0.001), have fewer years of education (40.8% vs 12.3%; p < 0.001), have low physical activity (27.3% vs 14.7%; p < 0.003), be obese (32.5% vs 24.4%; p = 0.02), and be current smokers (34.2% vs 10.3%; p < 0.001) compared to the not isolated ones. Mean fibrinogen levels increased with degree of social isolation (p = 0.003), but C-reactive protein showed no association (p = 0.52). Kaplan-Meier estimates indicated higher cancer mortality rates among participants with elevated fibrinogen levels, though not with statistical significance (p = 0.08). Furthermore, there was no association between social isolation and cancer mortality (p = 0.54). On multivariate analysis, obesity (HR = 1.56; 95% CI: 1.11–2.18), higher education (HR = 1.36; 95% CI: 1.01–1.83), and smoking (HR = 4.42, 95% CI: 2.84–6.88) were independent predictors for cancer mortality, while high physical activity predicted for lower mortality from cancer (HR = 0.67, 95% CI: 0.51–0.87). However, social isolation was not a predictor.

Conclusion
Social isolation among women was associated with an increased level of fibrinogen, but not associated with cancer mortality. The relationship between inflammation and cancer mortality warrants further investigation.
Late initiation and low utilization of postnatal care services among women in the rural setting in Northwest Tanzania: a community-based study using a mixed method approach
Authors: Konje Eveline T. , Hatfield Jennifer , Sauve Reg , Kuhn Susan , Magoma Moke , Dewey Deborah 
Published: July 2021

Abstract
Background
Maternal and newborn mortality is high immediately after childbirth and up to 42 days postnatally despite the availability of interventions. Postnatal care is crucial in preventing mortality and improving the health of women and newborns. This prospective cohort study investigated the initiation and utilization of postnatal care at health facilities and explored users’ and providers’ perspectives on utilization of postnatal care services.

Methods
A sequential explanatory mixed method was used involving women who were followed from the 3rd trimester of pregnancy to 3–4 months postnatally in Northwest, Tanzania. From January to December 2018, a door-to-door survey was conducted 3–4 months postnatally among 1385 of these women. A convenience sample of women and community health workers participated in focus group discussions, and traditional birth attendants and nurses participated in key informant interviews to complement quantitative data. Data analyses were conducted using STATA version 13 and NVIVO version 12.

Study findings
Approximately, one half of participants attended postnatal care within 42 days after delivery. Postnatal care seeking within 48 h after delivery was reported by 14.6 % of the participants. Women who attended antenatal care at least four times, delivered at health facilities or experienced delivery-related complications were more likely to seek postnatal care. Limited knowledge on the postnatal care services and obstetric complications after childbirth, and not being scheduled for postnatal care by health providers negatively influenced services uptake. Overwhelming workload and shortages of supplies were reported to hinder the provision of postnatal care services.

Conclusions
Utilization of postnatal care services remains low in this setting as a result of a number of disparate and complex factors that influence women’s choices. Provision of effective postnatal care is hindered by lack of supplies, staffing, and inadequate infrastructure. To ensure accessibility and availability of quality services in this setting, both demand and supply sides factors need to be addressed.
Roles of noncoding RNAs in preeclampsia
Authors: Sun Ningxia , Qin Shiting , Zhang Lu , Liu Shiguo 
Published: July 2021

AbstractPreeclampsia (PE) is an idiopathic disease that occurs during pregnancy. It comprises multiple organ and system damage, and can seriously threaten the safety of the mother and infant throughout the perinatal period. As the pathogenesis of PE is unclear, there are few specific remedies. Currently, the only way to eliminate the clinical symptoms is to terminate the pregnancy. Although noncoding RNA (ncRNA) was once thought to be the “junk” of gene transcription, it is now known to be widely involved in pathological and physiological processes, including pregnancy-related disorders. Moreover, there is growing evidence that the unbalanced expression of specific ncRNA is involved in the pathogenesis of PE. In the present review, we summarize the expression patterns of ncRNAs, i.e., microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), and the functional mechanisms by which they affect the development of PE, and examine the clinical significance of ncRNAs as biomarkers for the diagnosis of PE. We also discuss the contributions made by genetic polymorphisms and epigenetic ncRNA regulation to PE. In the present review, we wish to explore and reinforce the clinical value of ncRNAs as noninvasive biomarkers of PE.
Cost-effectiveness analysis of a multiple health behaviour change intervention in people aged between 45 and 75 years: a cluster randomized controlled trial in primary care (EIRA study)
Authors: Aznar-Lou Ignacio , Zabaleta-Del-Olmo Edurne , Casajuana-Closas Marc , Sánchez-Viñas Alba , Parody-Rúa Elizabeth , Bolíbar Bonaventura , Iracheta-Todó Montserrat , Bulilete Oana , López-Jiménez Tomàs , Pombo-Ramos Haizea , Martín Miguel María Victoria , Magallón-Botaya Rosa , Maderuelo-Fernández Jose Ángel , Motrico Emma , Bellón Juan , Martí-Lluch Ruth , Rubio-Valera Maria , Serrano-Blanco Antoni 
Published: July 2021

Abstract
Background
Multiple health behaviour change (MHBC) interventions that promote healthy lifestyles may be an efficient approach in the prevention or treatment of chronic diseases in primary care. This study aims to evaluate the cost-utility and cost-effectiveness of the health promotion EIRA intervention in terms of MHBC and cardiovascular reduction.

Methods
An economic evaluation alongside a 12-month cluster-randomised (1:1) controlled trial conducted between 2017 and 2018 in 25 primary healthcare centres from seven Spanish regions. The study took societal and healthcare provider perspectives. Patients included were between 45 and 75 years old and had any two of these three behaviours: smoking, insufficient physical activity or low adherence to Mediterranean dietary pattern. Intervention duration was 12 months and combined three action levels (individual, group and community). MHBC, defined as a change in at least two health risk behaviours, and cardiovascular risk (expressed in % points) were the outcomes used to calculate incremental cost-effectiveness ratios (ICER). Quality-adjusted life-years (QALYs) were estimated and used to calculate incremental cost-utility ratios (ICUR). Missing data was imputed and bootstrapping with 1000 replications was used to handle uncertainty in the modelling results.

Results
The study included 3062 participants. Intervention costs were €295 higher than usual care costs. Five per-cent additional patients in the intervention group did a MHBC compared to usual care patients. Differences in QALYS or cardiovascular risk between-group were close to 0 (-0.01 and 0.17 respectively). The ICER was €5,598 per extra health behaviour change in one patient and €1,727 per one-point reduction in cardiovascular risk from a societal perspective. The cost-utility analysis showed that the intervention increased costs and has no effect, in terms of QALYs, compared to usual care from a societal perspective. Cost-utility planes showed high uncertainty surrounding the ICUR. Sensitivity analysis showed results in line with the main analysis.

Conclusion
The efficiency of EIRA intervention cannot be fully established and its recommendation should be conditioned by results on medium-long term effects.

Trial registration
Clinicaltrials.gov NCT03136211. Registered 02 May 2017 – Retrospectively registered
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
Authors: Bichmann Maria , Prat Oriol Nuria , Ercan-Herbst Ebru , Schöndorf David C. , Gomez Ramos Borja , Schwärzler Vera , Neu Marie , Schlüter Annabelle , Wang Xue , Jin Liang , Hu Chenqi , Tian Yu , Ried Janina S. , Haberkant Per , Gasparini Laura , Ehrnhoefer Dagmar E. 
Published: July 2021

Abstract
Background
Human tauopathies including Alzheimer’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neuronal dysfunction and degeneration. While PTMs on aggregated Tau have been studied in detail, much less is known about the modification patterns of soluble Tau. Furthermore, PTMs other than phosphorylation have only come into focus recently and are still understudied. Soluble Tau species are likely responsible for the spreading of pathology during disease progression and are currently being investigated as targets for immunotherapies. A better understanding of their biochemical properties is thus of high importance.

Methods
We used a mass spectrometry approach to characterize Tau PTMs on a detergent-soluble fraction of human AD and control brain tissue, which led to the discovery of novel lysine methylation events. We developed specific antibodies against Tau methylated at these sites and biochemically characterized methylated Tau species in extracts from human brain, the rTg4510 mouse model and in hiPSC-derived neurons.

Results
Our study demonstrates that methylated Tau levels increase with Tau pathology stage in human AD samples as well as in a mouse model of Tauopathy. Methylated Tau is enriched in soluble brain extracts and is not associated with hyperphosphorylated, high molecular weight Tau species. We also show that in hiPSC-derived neurons and mouse brain, methylated Tau preferentially localizes to the cell soma and nuclear fractions and is absent from neurites. Knock down and inhibitor studies supported by proteomics data led to the identification of SETD7 as a novel lysine methyltransferase for Tau. SETD7 specifically methylates Tau at K132, an event that facilitates subsequent methylation at K130.

Conclusions
Our findings indicate that methylated Tau has a specific somatic and nuclear localization, suggesting that the methylation of soluble Tau species may provide a signal for their translocation to different subcellular compartments. Since the mislocalization and depletion of Tau from axons is associated with tauopathies, our findings may shed light onto this disease-associated phenomenon.
The anxious-depressive attack severity scale: development and initial validation and reliability
Authors: Noda Shota , Matsumoto Satomi , Kawasaki Naoko , Masaki Mina , Fukui Itaru , Kaiya Hisanobu 
Published: July 2021

Abstract
Background
Anxious-depressive attack (ADA) is a symptom complex that comprises sudden intense feelings of anxiety or depression, intrusive rumination of regretful memories or future worries, emotional distress due to painful thoughts, and coping behaviors to manage emotional distress. ADA has been observed trans-diagnostically across various psychiatric disorders. Although the importance of ADA treatment has been indicated, a scale to measure the severity of ADA has not been developed. This study aimed to develop an Anxious-Depressive Attack Severity Scale (ADAS) to measure the severity of ADA symptoms and examine its reliability and validity.

Methods
A total of 242 outpatients responded to a questionnaire and participated in an interview, which were designed to measure the severity of ADA, depressive, anxiety, anxious depression, and social anxiety symptoms. Based on the diagnostic criteria for ADA, 54 patients were confirmed to have ADA and were included in the main study analyses.

Results
The exploratory factor analysis of the ADAS identified a two factor structure: severity of ADA symptoms and ADA frequency and coping behaviors. McDonald’s ωt coefficients were high for the overall scale and the first factor (ωt = .78 and ωt = .83, respectively) but low for the second factor (ωt = .49). The ADAS score was significantly positively correlated with clinical symptoms related to anxiety and depression.

Conclusion
The present study demonstrated that the ADAS has sufficient reliability and validity; however, internal consistency was insufficient for the second factor. Overall, the ADAS has potential to be a valuable tool for use in clinical trials of ADA.
Fungal deterioration of the bagasse storage from the harvested sugarcane
Authors: Peng Na , Yao Ziting , Wang Ziting , Huang Jiangfeng , Khan Muhammad Tahir , Chen Baoshan , Zhang Muqing 
Published: July 2021

Abstract
Background
Sugarcane is an essential crop for sugar and ethanol production. Immediate processing of sugarcane is necessary after harvested because of rapid sucrose losses and deterioration of stalks. This study was conducted to fill the knowledge gap regarding the exploration of fungal communities in harvested deteriorating sugarcane. Experiments were performed on simulating production at 30 °C and 40 °C after 0, 12, and 60 h of sugarcane harvesting and powder-processing.

Results
Both pH and sucrose content declined significantly within 12 h. Fungal taxa were unraveled using ITS amplicon sequencing. With the increasing temperature, the diversity of the fungal community decreased over time. The fungal community structure significantly changed within 12 h of bagasse storage. Before stored, the dominant genus (species) in bagasse was Wickerhamomyces (W. anomalus). Following storage, Kazachstania (K. humilis) and Saccharomyces (S. cerevisiae) gradually grew, becoming abundant fungi at 30 °C and 40 °C. The bagasse at different temperatures had a similar pattern after storage for the same intervals, indicating that the temperature was the primary cause for the variation of core features. Moreover, most of the top fungal genera were significantly correlated with environmental factors (pH and sucrose of sugarcane, storage time, and temperature). In addition, the impact of dominant fungal species isolated from the deteriorating sugarcane on sucrose content and pH in the stored sugarcane juice was verified.

Conclusions
The study highlighted the importance of timeliness to refine sugar as soon as possible after harvesting the sugarcane. The lessons learned from this research are vital for sugarcane growers and the sugar industry for minimizing post-harvest losses.
Trends in evolution of the Rhodniini tribe (Hemiptera, Triatominae): experimental crosses between Psammolestes tertius Lent & Jurberg, 1965 and P. coreodes Bergroth, 1911 and analysis of the reproductive isolating mechanisms
Authors: Ravazi Amanda , de Oliveira Jader , Campos Fabricio Ferreria , Madeira Fernanda Fernandez , dos Reis Yago Visinho , de Oliveira Ana Beatriz Bortolozo , de Azeredo-Oliveira Maria Tercília Vilela , da Rosa João Aristeu , Galvão Cleber , Alevi Kaio Cesar Chaboli 
Published: July 2021

AbstractBackgroundThe tribe Rhodniini is a monophyletic group composed of 24 species grouped into two genera:RhodniusandPsammolestes. The genusPsammolestesincludes only three species, namelyP. coreodes,P. tertiusandP. arthuri. Natural hybridization events have been reported for the Rhodniini tribe (for genusRhodniusspecifically). Information obtained from hybridization studies can improve our understanding of the taxonomy and systematics of species. Here we report the results from experimental crosses performed betweenP. tertiusandP. coreodesand from subsequent analyses of the reproductive and morphological aspects of the hybrids.MethodsCrossing experiments were conducted betweenP. tertiusandP. coreodesto evaluate the pre- and post-zygotic barriers between species of the Rhodniini tribe. We also performed cytogenetic analyses of the F1 hybrids, with a focus on the degree of pairing between the homeologous chromosomes, and morphology studies of the male gonads to evaluate the presence of gonadal dysgenesis. Lastly, we analyzed the segregation of phenotypic characteristics.ResultsInterspecific experimental crosses demonstrated intrageneric genomic compatibility since hybrids were produced in both directions. However, these hybrids showed a high mortality rate, suggesting a post-zygotic barrier resulting in hybrid unviability. The F1 hybrids that reached adulthood presented the dominant phenotypic segregation pattern forP. tertiusin both directions. These insects were then intercrossed; the hybrids were used in the cross betweenP. tertius♀ ×P. coreodes♂ died before oviposition, and the F1 hybrids ofP. coreodes♀ xP. tertius♂ oviposited and their F2 hybrids hatched (however, all specimens died after hatching, still in first-generation nymph stage, pointing to a hybrid collapse event). Morphological analyses of male gonads from F1 hybrids showed that they did not have gonadal dysgenesis. Cytogenetic analyses of these triatomines showed that there were metaphases with 100% pairing between homeologous chromosomes and metaphases with pairing errors.ConclusionThe results of this study demonstrate thatPsammolestesspp. have intrageneric genomic compatibility and that post-zygotic barriers, namely unviability of hybrid and hybrid collapse, resulted in the breakdown of the hybrids ofP. tertiusandP. coreodes, confirming the specific status of species based on the biological concept of species.Graphical abstract
CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies
Authors: Marofi Faroogh , Saleh Marwan Mahmood , Rahman Heshu Sulaiman , Suksatan Wanich , Al-Gazally Moaed E. , Abdelbasset Walid Kamal , Thangavelu Lakshmi , Yumashev Alexei Valerievich , Hassanzadeh Ali , Yazdanifar Mahboubeh , Motavalli Roza , Pathak Yashwant , Naimi Adel , Baradaran Behzad , Nikoo Marzieh , Khiavi Farhad Motavalli 
Published: July 2021

AbstractAdoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells in the treatment of cancer, especially hematological cancers, has exposed CAR’s potential. However, the toxicity and significant limitations of CAR-T cell immunotherapy prompted research into other immune cells as potential candidates for CAR engineering. NK cells are a major component of the innate immune system, especially for tumor immunosurveillance. They have a higher propensity for immunotherapy in hematologic malignancies because they can detect and eliminate cancerous cells more effectively. In comparison to CAR-T cells, CAR-NK cells can be prepared from allogeneic donors and are safer with a lower chance of cytokine release syndrome and graft-versus-host disease, as well as being a more efficient antitumor activity with high efficiency for off-the-shelf production. Moreover, CAR-NK cells may be modified to target various antigens while also increasing their expansion and survival in vivo. Extensive preclinical research has shown that NK cells can be effectively engineered to express CARs with substantial cytotoxic activity against both hematological and solid tumors, establishing evidence for potential clinical trials of CAR-NK cells. In this review, we discuss recent advances in CAR-NK cell engineering in a variety of hematological malignancies, as well as the main challenges that influence the outcomes of CAR-NK cell-based tumor immunotherapies.
Modeling of co-channel interference in bluetooth low energy based on measurement data
Authors: Kavousi Ghafi Hamid , Spindelberger Christian , Arthaber Holger 
Published: July 2021

AbstractThe intense use of the 2.4 GHz ISM band by several wireless technologies has resulted in increased co-channel interference between networks operating in this frequency band. The aim of this paper is to investigate modeling techniques of co-channel interference affecting bluetooth low energy devices. The models are derived from recorded interference. Two types of models are introduced: a time domain model utilizing IQ data as reference and a spectrum-based model in which the reference signal is captured in frequency domain by a real-time spectrum analyzer. The recorded interference is also used as a reference to analyze the accuracy of proposed models. The proposed IQ-based model shows a degradation in performance for the environments with dominant bluetooth interfering signals. The frequency-based model not only addresses this problem, but also results in a huge data decimation in recording the interference.
Approximation of linear one dimensional partial differential equations including fractional derivative with non-singular kernel
Authors: Kamal Raheel , Kamran  , Rahmat Gul , Ahmadian Ali , Arshad Noreen Izza , Salahshour Soheil 
Published: July 2021

AbstractIn this article we propose a hybrid method based on a local meshless method and the Laplace transform for approximating the solution of linear one dimensional partial differential equations in the sense of the Caputo–Fabrizio fractional derivative. In our numerical scheme the Laplace transform is used to avoid the time stepping procedure, and the local meshless method is used to produce sparse differentiation matrices and avoid the ill conditioning issues resulting in global meshless methods. Our numerical method comprises three steps. In the first step we transform the given equation to an equivalent time independent equation. Secondly the reduced equation is solved via a local meshless method. Finally, the solution of the original equation is obtained via the inverse Laplace transform by representing it as a contour integral in the complex left half plane. The contour integral is then approximated using the trapezoidal rule. The stability and convergence of the method are discussed. The efficiency, efficacy, and accuracy of the proposed method are assessed using four different problems. Numerical approximations of these problems are obtained and validated against exact solutions. The obtained results show that the proposed method can solve such types of problems efficiently.