bluuebunny/crossref_metadata_2025_split huggingface dataset:
The waveform inversion of mainshock and aftershock data of the 2006 M6.3 Yogyakarta earthquake
Authors: Saputra Hijrah , Wahyudi Wahyudi , Suardi Iman , Anggraini Ade , Suryanto Wiwit 
Published: January 2021

Abstract
This study comprehensively investigates the source mechanisms associated with the mainshock and aftershocks of the Yogyakarta earthquake of magnitude Mw = 6.3 on May 27, 2006. Therefore, this study is to provide a more precise answer to the controversial source mechanism. This study uses moment tensor inversion to obtain fault plane parameters and joint inversion to obtain spatial and temporal slip distributions during an earthquake. The coseismic slip distribution is overlaid with the relocated aftershock distribution to see the stress field variations around the tectonic area of the study. Moment tensor inversion uses near-field data, and joint inversion uses near-field and teleseismic body wave data. The data is filtered by trial and error using a bandpass filter with frequency pairs and velocity models from several previous studies. The green's function for moment tensor inversion calculated using the extended reflectivity method and joint inversion computed using the Kikuchi and Kanamori methods. In this study, we apply the Akaike Bayesian Information Criterion (ABIC) method to obtain more stable inversion results. The results of the mainshock and aftershock moment tensor inversion show different fault types. The mainshock fault types are strike-slip and dip-normal types, while the 8th aftershock is of the same type as the mainshock, while the 9th and 16th June are strike slips. The joint inversion results show two asperities. The maximum slip is 0.78 m, with the first asperity 10 km south of the mainshock and the second asperity 10 km north of the mainshock. The obtained source parameters are total seismic moment M0 = 0.4311E + 19 (Nm) or Mw = 6.4, with a source depth of 12 km and a source duration of 28 seconds. Slip distribution overlay with aftershock distribution shows compatibility. The type of focus mechanism that results from this joint inversion is the oblique.
High Aedes spp. larval indices in Kinshasa, Democratic Republic of Congo
Authors: Francis Wat’senga Tezzo , Sylvie Fasine , Zola Manzambi Emile , Carmen Marquetti Maria del , Guillaume Binene Mbuka , Gillon Ilombe , Richard Mundeke Takasongo , Nathalie Smitz , Andre Bisset Juan , Wim Van Bortel , Vanlerberghe Veerle 
Published: January 2021

Abstract
BACKGROUND: Dengue, yellow fever, chikungunya and Zika are among the most important emerging infectious vector-borne diseases worldwide. In the Democratic Republic of Congo (DRC), increases in cases of dengue and outbreaks of yellow fever and chikungunya have been reported since 2010. The main vectors of these arboviruses, Aedes aegypti and Aedes albopictus, have been reported in DRC, but there is a lack of detailed information on their presence and spread to guide disease control efforts.METHODS: In 2018, two cross-sectional surveys were conducted in Kinshasa province (DRC), one in the rainy (January/February) and one in the dry season (July). Four hundred houses were visited in each of the four selected communes (N’Djili, Mont Ngafula, Lingwala and Kalamu). Within the peri-domestic area of each household, searches were conducted for larval habitats which were then surveyed for the presence of Aedes larvae and pupae. A subset of the immature specimens were reared to adults for morphological identification followed by DNA-barcoding of the specimens to validate identifications.RESULTS: The most rural commune (Mont Ngafula) had the highest pupal index of 246 (20) pupae/100 houses and a Breteau Index of 82.2 (19.5)/100 houses, while this latter was 21.5 (4.7), 36.7 (9.8) and 41.7 (7.5) in Kalamu, Lingwala and N’Djili in the rainy (and dry) season, respectively. The House Index was on average across all communes 27.5% (7.6%); and the Container Index 15.0% (10.0%) in rainy (and dry) season, respectively. The vast majority of Aedes positive containers were found outside the houses (adjusted OR 27.4 (95%CI 14.9-50.1)). During the dry season, the most productive containers were the ones used for water storage, whereas in the rainy season rubbish and tires constituted key habitats. Both Ae. aegypti and Ae. albopictus were found. Anopheles larvae were found in different types of Aedes larval habitats, especially during the rainy season. CONCLUSIONS: In both surveys and in all communes, the larval indices (BI) were higher than the arbovirus transmission threshold values established by the World Health Organization. Management strategies for controlling Aedes in Kinshasa need to target the key containers, mainly located in outdoor spaces, for larval habitats destruction or reduction.
The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention
Authors: Liu Yong-Sheng , Wei Mei , Wang Le , Liu Gang , Ma Guo-Ping , Ono Katsushige , Cao Ze-Long , Yang Man , Zheng Ming-Qi 
Published: January 2021

Abstract
Background Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the association between SCH and long-term outcomes in older patients undergoing PCI.Methods and Results 3168 patients aged 65 years or older who underwent PCI from January 2012 to October 2013 were included. Patients were divided into SCH group (n=320) and euthyroidism (ET) group (n=2848) based on thyroid function test. Cox proportional hazard regression analyses were used to estimate the relative risks (RRs) of all-cause death and cardiac death for patients with SCH during a 4-year follow-up period. There were 227 deaths during the follow-up period including 124 deaths caused by cardiac events. There was no significant difference in mortality rate between the SCH group and the ET group (p>0.05). After adjustment for covariates, compared with patients with ET, the RRs of death from all-cause and cardiac in patients with SCH were 1.261 (95%CI: 0.802-1.982, p=0.315) and 1.231 (95%CI: 0.650-2.334, p=0.524), respectively. When SCH was stratified by age, gender, and degree of thyroid-stimulating hormone elevation, no significant associations were also found in any stratum. Conclusion Our investigation revealed that SCH was negatively associated with the outcome of PCI in older patients.
Graphene Oxide Exacerbates Dextran Sodium Sulfate-Induced Colitis via ROS/AMPK/p53 Signaling to Mediate Apoptosis
Authors: Liu Siliang , Xu Angao , Gao Yanfei , Xie Yue , Liu Zhipeng , Sun Meiling , Mao Hua , Wang Xinying 
Published: January 2021

Abstract
Background: Graphene oxide (GO), a novel carbon-based nanomaterial, has promising applications in biomedicine. However, it induces potential cytotoxic effects on the gastrointestinal (GI) tract cells, and these effects have been largely uncharacterized. The present study aimed to explore the toxic effects of GO on the intestinal tract especially under pre-existing inflammatory conditions, such as inflammatory bowel disease (IBD), and elucidate underlying mechanisms.Results: Our findings indicated that oral gavage of GO worsened acute colitis induced by 2.5% dextran sodium sulfate in mice. In vitro, toxic effects including decreased cell viability, as well as the elevated release of lactic dehydrogenase (LDH) in FHC cell line, an ideal model of intestinal epithelial cells (IECs), were observed. Moreover, GO treatment triggered apoptosis in FHC cells through the activation of reactive oxygen species (ROS)/AMP-activated protein kinase (AMPK)/p53 pathway, as evidenced by the upregulation of cytochrome c (Cytc), Bax, and cleaved caspase-3 (c-cas3) and the downregulation of Bcl-2. Interestingly, pretreatment with an antioxidant, N-acetyl-L-cysteine, and a specific inhibitor of AMPK activation, Compound C (Com.C), effectively inhibited GO-induced apoptosis in FHC cells.Conclusions: Our data demonstrate that GO-induced IECs apoptosis via ROS/AMPK/p53 pathway activation accounts for the exacerbation of colitis in mice. These findings provide a new insight into the pathogenesis of IBD induced by environmental factors. Furthermore, our findings enhance our understanding of GO as a potential environmental toxin, which helps delineate the risk of exposure to patients with disturbed intestinal epithelial barrier/inflammatory disorders such as IBD.
Structural stigma and its impact on healthcare for consumers with Borderline Personality Disorder: protocol for a scoping review
Authors: Klein Pauline , Fairweather A. Kate , Lawn Sharon , Stallman Helen , Cammell Paul 
Published: January 2021

Abstract
BackgroundStructural stigma in health systems experienced by consumers diagnosed with Borderline Personality Disorder (BPD), is a widespread phenomenon that causes major health inequities and harm for this population. Structural stigma in this context relates to institutional policies, cultural norms, and organizational practices that limits consumers’ access to health services, quality of care, and capacity to achieve optimal health and well-being. BPD is a serious mental illness with high morbidity and mortality, characterized by instability in interpersonal relationships, self-image, and emotional and behavioral deregulation, which stem from significant traumatic childhood/life events, and/or biological aetiologies. The objectives of this scoping review are to explore the international literature on structural stigma in healthcare systems specific to BPD, and to provide an overview of the impact of structural stigma on health services for BPD consumers, and their carers/families.MethodsThis scoping review will follow the Joanna Briggs Institute (JBI) scoping review guidelines. We will search the following electronic databases (from inception onwards): MEDLINE, CINAHL, PsycINFO, Scopus, Cochrane Library, and JBI-Evidence databases. Grey literature will be identified through the Google search engine. We will include all types of literature in English, published and unpublished, including any study design, reviews, clinical practice guidelines, policy reports, and other documents. No restrictions on publication date of sources of evidence will be applied. International literature should examine structural stigma associated with BPD in any healthcare setting such as, outpatients, inpatients, primary health care, or community-based facilities. Two reviewers will independently screen all titles, abstracts and full-text citations. Quality appraisal of the included sources of evidence will be assessed using the Mixed Methods Appraisal Tool (MMAT) 2018 version. Data analysis will involve quantitative (e.g., frequencies) and qualitative (e.g., thematic analysis) methods. DiscussionThis review is anticipated to enhance both identification and understanding of those structures in health systems (i.e., institutional policies, cultural norms, and practices), that manifest and perpetuate stigma experienced by consumers with BPD, and their carers/families. The findings can be used to inform future research, policy and practice relating to stigma reduction strategies that can be adopted to improve the provision of BPD-responsive services and care for this population. Systematic review registration: Open Science Framework (https://osf.io/bhpg4).
Genetic epidemiological characteristics of a Hungarian subpopulation of patients with Huntington’s Disease
Authors: Despotov Katalin , Zádori Dénes , Veres Gábor , Jakab Katalin , Gárdián Gabreilla , Tóth Eszter , Kincses Tamás Zsigmond , Vecsei Laszlo , Ajtay Andras , Bereczki Dániel , Klivenyi Peter 
Published: January 2021

Abstract
Background: Recent advances in therapeutic options may prevent deterioration related to Huntington’s disease (HD), even at the pre-symptomatic stage. Be that as it may, a well-characterized patient population is essential for screening and monitoring outcome. Accordingly, the aim of this study was to describe the characteristics of a Hungarian subpopulation of HD patients and mutation carriers diagnosed at the University of Szeged. Methods: We conducted a search for International Classification of Diseases (ICD) code G10H0 in the local medical database for the period of 1 January 1998 to 31 December 2018. Results: We identified 90 HD cases (male: 45, female: 45) and 34 asymptomatic carriers (male: 15, female: 19). The median age of onset was 45 years (range: 16-79). There were 3 cases of juvenile onset (3.3%), and 7 of late disease onset (7.8%). The median repeat length was 43 (range: 36-70) for the pathological and 19 for the non-pathological alleles (range: 9-35). 17.5% of the pathological alleles were in the decreased penetrance range, while 7% of non-pathological alleles were intermediate. Conclusions: The genetic and clinical features of the population examined in the present study were in line with the previous Hungarian study, as well as with international literature. The exceptions were the higher ratio of reduced penetrance and intermediate alleles.
MSE Minimized Joint Transmission in Coordinated MultiPoint Systems with Sparse Feedback and Constrained Backhaul Requirements
Authors: Nezafati Mohammad Bagher , Taki Mehrdad , Svensson Tommy 
Published: January 2021

Abstract
In a joint transmission coordinated multipoint (JT-CoMP) system, a shared spectrum is utilized by all neighbor cells. In the downlink, a group of base stations (BSs) coordinately transmit the users’ data to avoid serious interference at the users in the boundary of the cells, thus substantially improving area fairness. However, this comes at the cost of high feedback and backhaul load; In a frequency division duplex (FDD) system, all users at the cell boundaries have to collect and send feedback of the downlink channel state information (CSI). In centralized JT-CoMP, although with capabilities for perfect coordination, a central coordination node (CCN) have to send the computed precoding weights and corresponding data to all cells which can overwhelm the backhaul resources. In this paper, we design a JT-CoMP scheme, by which the sum of the mean square error (MSE) at the boundary users is minimized, while feedback and backhaul loads are constrained and the load is balanced between BSs. Our design is based on the singular value decomposition (SVD) of CSI matrix and optimization of a binary link selection matrix to provide sparse feedback -constrained backhaul link. For comparison, we adopt the previously presented schemes for feedback and backhaul reduction in the physical layer. Extensive numerical evaluations show that the proposed scheme can reduce the MSE with at least 25%, compared to the adopted and existing schemes.
Insight of Transcriptional Regulators reveals the Tolerance Mechanism of Carpet-grass (Axonopus compressus) Against Drought
Authors: Nawaz Mohsin , Li Liao , Azeem Farrukh , Shabbir Samina , Zohaib Ali , Ashraf Umair , Yang Hubiao , Wang Zhiyong 
Published: January 2021

Abstract
Background: Carpet grass [Axonopus compressus (L.)] is an important warm-season perennial grass around the world and is known for its adaptability to varied environmental conditions. However, Carpet grass lacks enough data in public data banks, which confined our comprehension of the mechanisms of environmental adaptations, gene discovery, and development of molecular markers. In current study, the DEGs (differentially expressed genes) in Axonopus compressus under drought stress (DS) were identified and compared with CK (control) by RNA-Seq. Results: A total of 263,835 unigenes were identified in Axonopus compressus, and 201,303 (also added to the numbers of the remaining 2 databases) a sequence of unigenes significantly matched in at least one of the seven databases. A total of 153697 (58.25%) unigenes classified to 144 KEGG pathways, and 7,444 unigenes were expressed differentially between DS and CK, of which 4,249 were up-regulated and 3,195 were down-regulated unigenes. Of the 50 significantly enriched GO terms, 18, 6, and 14 items were related to BP, CC, and MF respectively. Analysis of KEGG enrichment revealed 2569 DEGs involved in 143 different pathways, under drought stress. 2,747 DEGs were up-regulated and 2,502 DEGs were down-regulated. Moreover, we identified 352 transcription factors (TFs) in Axonopus compressus, of which 270 were differentially expressed between CK and DS. The qRT-PCR validation experiment also supports the transcriptional response of Axonopus compressus against drought. Accuracy of transcriptome unigenes of Axonopus compressus was assessed with BLAST, which showed 3,300 sequences of Axonopus compressus in the NCBI.Conclusion: The 7,444 unigenes were found to be between DS and CK treatments, which indicate the existence of a strong mechanism of drought tolerance in Axonopus compressus. The current findings provide the first framework for further investigations for the particular roles of these unigenes in Axonopus compressus in response to drought.
Communication of Pharmacogenomic Test Results and Treatment Plans in Pediatric Oncology: Deliberative Stakeholder Consultations with Parents
Authors: Longo Cristina , Rahimzadeh Vasiliki , Bartlett Gillian 
Published: January 2021

Abstract
Background: Effective communication in support of clinical decision-making is central to the pediatric cancer care experience for families. A new laboratory derived pharmacogenetic test (LDT) that can diagnose difficult-to-treat brain cancers has been developed to stratify children based on their ability to respond to available treatment; however, the potential implementation of the LDT may make effective communication challenging since it can potentially remove the option for curative treatment in those children identified as non-responders, i.e. those with a catastrophic diagnosis. Objective: We solicited the perspectives of parents of children with difficult-to-treat brain cancer on communication preferences surrounding the potential implementation of the LDT in standard care using deliberative stakeholder consultations.Methods: Eight bereaved parents of children who succumbed to difficult-to-treat brain cancer, and four parents of children currently undergoing treatment for similar cancers attended separate small-group deliberative consultations – a stakeholder engagement method that enables the co-creation of recommendations following the consideration of competing arguments and diverse opinions of parents with different experiences. In the small-group consultations (Phase I), parents discussed four questions about potential communication issues that may arise with the LDT in practice. In Phase II, a total of five parents from both stakeholder groups (4 bereaved and 1 in current treatment) attended a consultation, known as the ‘mixed’ consultation, with the purpose of co-developing concrete recommendations for implementation of the LDT.Results: Explaining the risks, benefits, and accuracy of the LDT were considered essential to parents. Once an LDT-based diagnosis/prognosis can be made, parents valued honesty, empathy, and clarity in communication. Parents also requested that all results and treatment options be presented to them in measured doses, and in an unbiased manner over the course of several meetings. This communication strategy allowed sufficient time to understand and accept the diagnosis/prognosis, particularly if it was catastrophic. Continuous access to the appropriate psychological and social support or counselling at and post-diagnosis was also strongly recommended.Conclusions: Deliberants co-created family-centered recommendations surrounding communication issues of the LDT, providing guidance to pediatric oncologists that could implement the test in practice.
An Approach to Exploring Associations between Hospital Structural Measures and Patient Satisfaction by Distance-based Analysis
Authors: Okuda Masumi , Yasuda Akira , Tsumoto Shusaku 
Published: January 2021

Abstract
Background: Patient satisfaction studies have explored domains of patient satisfaction, the determinants of domains, and score differences of domains by patient/hospital structural measures but reports on the structure of patient satisfaction with respect to similarities among domains are scarce. This study is to explore by distance-based analysis whether similarities among patient-satisfaction domains are influenced by hospital structural measures, and to design a model evaluating relationships between the structure of patient satisfaction and hospital structural measures.Methods: The Hospital Consumer Assessment of Healthcare Providers and Systems 2012 survey scores and their structural measures from the Hospital Compare website reported adjusted percentages of scale for each hospital. Contingency tables of nine measures and their ratings were designed based on hospital structural measures, followed by three different distance-based analyses - clustering, correspondence analysis, and ordinal multidimensional scaling – for robustness to identify homogenous groups with respect to similarities.Results: Of 4,677 hospitals, 3,711 (79.3%) met the inclusion criteria and were analyzed. The measures were divided into three groups plus cleanliness. Certain combinations of these groups were shown to be dependent on hospital structural measures. High value ratings for communication and low value ratings for medication explanation, quietness and staff responsiveness were not influenced by hospital structural measures, but the varied-ratings domain group similarities, including items such as global evaluation and pain management, were affected by hospital structural measures.Conclusions: Distance-based analysis can reveal the hidden structure of patient satisfaction. This study suggests that hospital structural measures including hospital size, the ability to provide acute surgical treatment, and hospital interest in improving medical care quality are factors which may influence the structure of patient satisfaction.
The impact of COVID-19 on chronic care according to providers: a qualitative study among primary care practices in Belgium
Authors: Danhieux Katrien , Buffel Veerle , Pairon Anthony , Benkheil Asma , Remmen Roy , Wouters Edwin , Olmen Josefien Van 
Published: January 2021

Abstract
Background. The COVID-19 pandemic affects the processes of routine care for chronic patients. A better understanding helps to increase resilience of the health system and prepare adequately for next waves of the pandemic.Methods. A qualitative study was conducted in 16 primary care practices: 6 solo working, 4 monodisciplinary and 7 multidisciplinary. 21 people (doctors, nurses, dieticians) were interviewed, using semi-structured video interviews. A thematic analysis was done using the domains of the Chronic Care Model (CCM).Results. Three themes emerged: changes in health care organization, risk stratification and self-management support. All participating practices reported drastic changes in organization with a collective shift towards COVID-19 care, and reduction of chronic care activities, less consultations, and staff responsible for self-management support put on hold. A transition to digital support did not occur. Few practitioners had a systematic approach to identify and contact high-risk patients for early follow-up. A practice with a pre-established structured team collaboration managed to continue most chronic care elements. Generally, practitioners expected no effects of the temporary disruption for patients, although they expressed concern about patients already poorly regulated.Conclusion: Our findings show a disruption of the delivery of chronic care in the Belgium prim care context. In such contexts, the establishment of the CCM can facilitate continuity of care in crisis times. Short term actions should be directed to facilitate identifying high-risk patients and to develop a practice organization plan to organize chronic care and use digital channels for support, especially to vulnerable patients, during next waves of the epidemic.