bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desinfecção à base de radiação ultravioleta-c: um estudo bibliométrico no contexto internacional
Authors: Couto Jackeline Franco , Silva Maguel Souza da , Machado Wiliam César Alves , Tyrrel Maria Antonieta Rúbio , Couto Fellipe Franco , Nunes Márcia Adriana Silva , Figueiredo Nébia Maria  Almeida de 
Published: January 2021

Objetivo: Identificar e analisar a produção científica sobre o uso de raios ultravioleta-c para fins de desinfecção, descontaminação e esterilização, publicada em artigos de periódicos no período de 2014 a 2018. Métodos: Pesquisa exploratória com abordagem quali-quantitativa, realizada na base de dados Web of Science. Resultados: Foram recuperados 230 artigos científicos, o ano de 2018 apresentou o maior número de artigos (29%). Estados Unidos da América (28%) foi o maior país gerador de publicações e o idioma inglês (98%) o mais recorrente. O mapeamento da distribuição de artigos por periódico, apontou que 16 (15%) revistas concentraram a publicação de 99 (43%) artigos. A averiguação das aplicações da radiação ultravioleta-c apontou a predominância em alimentos (32%) e as bactérias (53%) dentro do levantamento dos microrganismos alvos. Conclusão: As publicações sobre o uso da tecnologia apontam sua diversidade de aplicação nos diferentes segmentos, tais como indústria de alimentos e ambientes hospitalares.
Antisynthetase Syndrome-Associated Interstitial Lung Disease: Monitoring of Immunosuppressive Treatment Effects by Chest Computed Tomography
Authors: Korsten Peter , Rademacher Jan-Gerd , Riedel Linn , Schnitzler Eva-Maria , Olgemöller Ulrike , Seitz Cornelia Sabine , Schmidt Jens , Larsen Jörg , Vasko Radovan 
Published: January 2021

Background: Antisynthetase syndrome (ASyS) is a rare autoimmune disease characterized by inflammatory myopathy, arthritis, fever, and interstitial lung disease (ILD). Pulmonary involvement in ASyS significantly increases morbidity and mortality and, therefore, requires prompt and effective immunosuppressive treatment. Owing to the rarity of ASyS, limited data exists on progression and prognosis of ILD under immunosuppression.Objectives: The objective of the study was to evaluate the radiological progression and outcome measures of ILD with immunosuppressive therapy in patients with ASyS.Methods: Twelve patients with ASyS-associated ILD (ASyS-ILD) were included. Demographic and clinical data, including organ involvement, pulmonary function tests (PFT), laboratory parameters, imaging studies, and treatment regimens were retrospectively analyzed from routinely collected data. The extent of ground glass opacities, fibrotic changes and honeycombing was analyzed and scored using high-resolution chest computed tomography (HRCT) scans. HRCT findings were compared between baseline and follow-up examinations. In addition, patients were stratified depending on whether they had received rituximab (RTX) or not.Results: Pulmonary function tests revealed stable lung function and follow-up HRCT scans showed an improvement of radiological alterations in the majority of ASyS patients under immunosuppressive therapy. We did not detect significant differences between the RTX- and non-RTX-treated groups, but the RTX-treated patients more frequently had myositis and relapsing disease.Conclusions: Radiographic alterations in ASyS-associated ILD respond to immunosuppressive treatment. RTX is a feasible treatment option with similar clinical and radiographic outcomes in patients with relapsing disease and clinically apparent myositis.
Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma
Authors: Xu Wenhao , Hu Xiaoxin , Anwaier Aihetaimujiang , Wang Jun , Liu Wangrui , Tian Xi , Zhu Wenkai , Ma Chunguang , Wan Fangning , Shi Guohai , Qu Yuan-Yuan , Zhang Hailiang , Ye Dingwei 
Published: January 2021

Purpose: Lipid metabolism reprogramming is a major pathway in tumor evolution. This study investigated fatty acid synthase (FASN) mRNA expression in anthropometric adipose tissue and elucidated the prognostic value and potential mechanism of clear cell renal cell carcinoma (ccRCC).Materials and Methods: Transcription profiles were obtained from 533 ccRCC samples in The Cancer Genome Atlas (TCGA) cohorts. Real-time quantitative PCR (RT-qPCR) and immunohistochemistry were performed to detect FASN expression in 380 paired ccRCC and normal tissues from the Fudan University Shanghai Cancer Center (FUSCC). Visceral adipose tissue (VAT) and subcutaneous adipose tissue were at the level of the umbilicus as measured by magnetic resonance imaging (MRI). Non-targeted metabolomics and in vitro experiments were used to reveal the biological functions of FASN.Results: Increased FASN expression was significantly relevant to advanced T, N, and American Joint Committee on Cancer (AJCC) stages (p &lt; 0.01) and significantly correlated to poor progression-free survival (PFS) and overall survival (OS) of 913 ccRCC patients in FUSCC and TCGA cohorts. Pearson's correlation coefficient indicated that FASN amplification was positively correlated to VAT% (r = 0.772, p &lt; 0.001), which significantly correlated to poor PFS (HR = 2.066, p = 0.028) and OS (HR = 2.773, p = 0.023) in the FUSCC cohort. Transient inhibition or overexpression of FASN significantly regulated A498 and 786O cell proliferation and migration by regulating epithelial–mesenchymal transition. Inhibition of FASN led to a higher apoptotic rate and decreased lipid droplet formation compared with normal control in ccRCC cells. Non-targeted metabolomics showed that decreased de novo lipogenesis might be required to sustain an elevation of glycolytic activity in 786O cells by regulating galactinol, dl-lactate, N-acetylaspartylglutamate, and sucrose, thereby participating in carcinogenesis and progression of ccRCC.Conclusion: This study demonstrated that FASN expression is positively related to aggressive cell proliferation, migration, apoptosis, and lipid droplet formation and regulates metabolic disorders of the ccRCC microenvironment. Additionally, elevated FASN mRNA expression is significantly correlated to the abdominal obesity distribution, especially VAT%, which is a significant predictor of a poor prognosis for ccRCC patients.
Risk and Prognosis of Secondary Bladder Cancer After Radiation Therapy for Rectal Cancer: A Large Population-Based Cohort Study
Authors: Guan Xu , Wei Ran , Yang Runkun , Lu Zhao , Liu Enrui , Zhao Zhixun , Chen Haipeng , Yang Ming , Liu Zheng , Jiang Zheng , Wang Xishan 
Published: January 2021

BackgroundAlthough radiation therapy (RT) improves local control for rectal cancer (RC), the long-term risks from RT, including development of a secondary malignancy, are controversial. The risk and prognosis of secondary bladder cancer (SBC) in RC patients undergoing RT have not been adequately studied. Our goal is to investigate the impact of RT on the risk of developing SBC and assess their survival outcomes.MethodsThis large population-based study included RC patients as their initial primary cancer from nine registries of the Surveillance, Epidemiology and End Results (SEER) database between 1973 and 2015. The cumulative incidence of SBC was assessed by using Fine and Gray’s competing risk regression. The standardized incidence ratio (SIR) was used to compare the incidence of SBC in RC survivors to the US general population. The Kaplan-Meier method was used to evaluate the 10-year overall survival (OS) and 10-year cancer specific survival (CSS) for patients with SBC.ResultsOf 74,646 RC patients, 24,522 patients were treated with surgery and RT and 50,124 patients were treated with surgery alone. The incidence of SBC was 1.85% among patients who received RT and 1.24% among patients who did not. The incidence of SBC in RC patients who received RT was higher than the US general population (SIR, 1.35; 95% CI, 1.19-1.53, P&lt;0.05), and decreased with increasing age at diagnosis, and increased with time since diagnosis. In competing risk regression analysis, undergoing RT was associated with a higher risk of SBC (hazard ratio [HR], 1.443, 95% confidence interval [CI], 1.209-1.720; P&lt;0.001). The results of the dynamic SIR for SBC revealed that a slightly increased risk of SBC was observed after RT in the early latency, and was significantly related to the variations of age at RC diagnosis and decreased with time progress. The 10-year OS and CSS among SBC patients after RT were comparable to SBC patients after NRT.ConclusionRadiation was associated with an increased risk of developing SBC in RC patients, and special attention should be paid to the surveillance of these patients.
Creatinine Trends to Detect Ibuprofen-Related Maturational Adverse Drug Events in Neonatal Life: A Simulation Study for the ELBW Newborn
Authors: van Donge Tamara , Allegaert Karel , Pfister Marc , Smits Anne , van den Anker John 
Published: January 2021

Background:Recognizing a change in serum creatinine concentrations is useful to detect a renal adverse drug reaction signal. Assessing and characterizing the nephrotoxic side-effects of drugs in extremely low birth weight (ELBW, ≤1000 g) neonates remain challenging due to the high variability in creatinine in this population. This study aims to investigate and quantify the impact of ibuprofen treatment on kidney function, reflected by serum creatinine.Method:A recently developed dynamical model for serum creatinine was used to simulate creatinine profiles for typical, reference ELBW neonates with varying gestational and postnatal ages whilst being exposed to ibuprofen treatment.Results:The increase of serum creatinine concentrations due to ibuprofen treatment is most apparent during the first week of life. The difference in serum creatinine values between ibuprofen-exposed vs. non-exposed neonates decreases with increasing postnatal age, independent of gestational age.Conclusion:The difference in serum creatinine concentrations between ibuprofen-exposed vs. non-exposed neonates decreases with postnatal age, indicating an increased clearing capacity and resulting in a weak ibuprofen-related adverse drug reaction signal beyond early neonatal life.
Inflammatory Activities in Type 2 Diabetes Patients With Co-morbid Angiopathies and Exploring Beneficial Interventions: A Systematic Review
Authors: Nwadiugwu Martin C. 
Published: January 2021

Background: Diabetes is a long-term condition that can be treated and controlled but do not yet have a cure; it could be induced by inflammation and the goal of managing it is to prevent additional co-morbidities and reduce glycemic fluctuations. There is a need to examine inflammatory activities in diabetes-related angiopathies and explore interventions that could reduce the risk for future outcome or ameliorate its effects to provide insights for improved care and management strategies.Method: The study was conducted in Embase (1946–2020), Ovid Medline (1950–2020), and PubMed databases (1960–2020) using the PICO framework. Primary studies (randomized controlled trials) on type 2 diabetes mellitus and inflammatory activities in diabetes-related angiopathies were included. Terms for the review were retrieved from the Cochrane library and from PROSPERO using its MeSH thesaurus qualifiers. Nine articles out of 454 total hits met the eligibility criteria. The quality assessment for the selected study was done using the Center for Evidence-Based Medicine Critical Appraisal Sheet.Results: Data analysis showed that elevated CRP, TNF-α, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome. Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events. Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant (p &lt; 0.05) reduction in inflammatory activities.Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.
Sensitive detection of alkyne-terminated hydrophobic drug by surface-enhanced stimulated Raman scattering in cetyltrimethylammonium bromide-coated gold nanorod suspensions
Authors: Mizuguchi Takaha , Nuriya Mutsuo , Yasui Masato , Iino Takanori , Ozeki Yasuyuki , Saiki Toshiharu 
Published: January 2021

Abstract
We demonstrate the sensitive detection of alkyne-terminated ethinylestradiol (EE2) in a cetyltrimethylammonium bromide (CTAB)-coated gold nanorod (AuNR) suspension by surface-enhanced stimulated Raman scattering (SRS). Since alkynes show a distinct Raman peak at the silent wavenumber region, EE2 can be detected by obtaining the alkyne-specific SRS signals. Here we find the CTAB coating uniformly adsorbs the hydrophobic EE2 and enables it to exist in the plasmonic hotspot of AuNRs without the alkyne binding to AuNR surfaces. As a result, ensemble-averaged plasmonic enhancement using a CTAB-coated AuNR suspension improved the detection limit for SRS signals from EE2 by one order of magnitude.
Polyresistance of salmonell serovov, isolated from Poultry and from poultry products
Authors: Loshchinin M. N. , Sokolova N. A. , Abdullaeva A. M. 
Published: January 2021

Salmonellosis remains an important problem not only in the Russian Federation, but throughout the world, both in veterinary medicine and in medicine. Poultry is the most affected by salmonella. Most often, S. Enteritidis, S. Typhimurium, S. Infantis, S. Gallinarum-pullorum are isolated from poultry and poultry products. It is these salmonella serovars that cause outbreaks of foodborne diseases in humans. For the prevention and treatment of salmonellosis, antibiotics of various groups are used: β-lactams, fluoroquinolones, cephalosporins, etc. Unfortunately, at present, most of the latest generation antibiotics are ineffective. However, many Salmonella isolates have been found to have multiple drug resistance (MDR). MDR strains began to actively displace those that were resistant to only one or two antibiotics. Antibioticresistant bacterial strains are transmitted to humans through the use of insufficiently heattreated poultry meat, through contact with raw poultry products, as well as through eggs and egg products. 45 strains of Salmonella isolated from sick poultry, as well as carcasses and poultry meat products were studied. Cultivation, study of biochemical, serological properties and virulence were carried out according to standard methods. Sensitivity to 35 antibiotics was determined using the disk diffusion method. In the study of antibiotic resistance of Salmonella serovars S. Enteritidis, S. Typhimurium, S. Infantis, it was found that they all had multidrug resistance, and most of the strains were resistant to 11–18 drugs out of 35 used. №t a single strain was found that was resistant to only 1–7 antibiotics. All strains were multiresistant, with 100% of Salmonella resistant to clindamycin, tylosin, oleandomycin, rifampicin, ampicillin, and penicillin. More than 80% of the studied strains were resistant to erythromycin, doxycycline, tetracycline. Aminoglycosides (kanamycin, neomycin, streptomycin, gentamicin, amikacin), amphenicols (chloramphenicol) suppressed the growth of 60–90% of Salmonella strains. The most effective were fluoroquinolones of the 2nd and 3rd generation, capable of inhibiting the growth of 80-100% of isolates, especially ciprofloxacin and enrofloxacin. These drugs are backup antibiotics. However, isolates resistant to ciprofloxacin and enrofloxacin have been found, which is alarming. 4th generation fluoroquinolones have been shown to be less effective, especially for S. infantis. Perhaps this is due to the use of fluoroquinolones among poultry at large poultry enterprises for the prevention of salmonellosis. Only about 30% of isolates were resistant to first-generation cephalosporins (cefazolin, cephalexin). Among the 3rd generation cephalosporins, the most effective were cephaperazone and especially ceftriaxone, to which no Salmonella isolate was resistant. 47% of S. Typhimurium is resistant to cefepime (4th generation cephalosporin), while sensitivity to other serovariants is up to 67%.
Protection of planting of potatoes from segetal vegetation
Authors: Shyta О. 
Published: January 2021

Goal. To investigate measures of limiting the number of weeds in planting potatoes on the yield of culture.
Methods. Field, comparative and analytical.
Results. The data of technical and economic efficiency of application in landings of potatoes of soil and insurance herbicides, as well as their mixtures are given. It was established that the application after formation of the crests of soil herbicide Zenkor Likvid SC in the normal rate of 1.1 l/ ha provided technical efficiency in 30 days at 77.8%, but did not provide full protection of planting of potato from cereal weeds. Spraying to seedlings with herbicide Zenkor Liquid SC normally consumes 1.1 l/ha and the introduction of Panther antimicrobial herbicide during the period of vegetation, the normally consumes 2.0 l / hectares provided technical efficiency in 30 days at 88.9%. Application in the growing season of the herbicide mixture culture Zenkor Liquid SC + Titus 25, WG in the norms of consumption of 0.2 l/ha + 30 g/ha + surfactant Trend 90, 200 ml / hectare provided technical efficiency at the level of 94.4% for the height of plants of culture 5—10 cm, and at for plant height 10—15 cm — 86.1%. Technical efficiency of the herbicide Titus 25, WG Normally, the consumption of 50 g/ha + surfactant Trend 90, 200 ml/ha was 88.9%, 30 days after spraying, and manual gutting — 80.6%. In variants with application of herbicides yield of potatoes at the level of 18.4—22.0 t/ ha was obtained, in the manual with manual propelling — 18.6 t/ ha, with a yield of 11.2 t/ha.
Conclusions. To reduce segetal vegetation in potato positions and obtain high yields of tubers it is expedient to spray with soil herbicide Zenkor Liquid SC after the formation of crests to the seedlings of the culture and weeds, the COP normally consumes 1.1 l/ha (metrubuzin, 600 g/l) and in Period of vegetation with herbicide against cereal weeds. During the growing season of potatoes, at a height of culture of 5—10 cm, when weed plants are in the initial stages of growth, landing is sprayed with a mixture of soil and insurance herbicide Zenkor Liquid SC + Titus 25, WG in reduced rates of spending.
Knowledge of Mothers Regarding Measles Control in Primary Health Care Centers in Al- Samawa City
Authors: Salwan Abdullah Naji , Khadija S. AL-Mizury, Shatha K. Atrah  
Published: January 2021

Background:Measles is a very communicable viral illness that can be prevented by immunization.
knowledge is key tools to control of disease.
Objectives:The aims of study were identify mothers knowledge regarding measles control and immunization.
Methods:A cross sectional study (descriptive study ) was conducted in Al-Samawa city/Iraq during the
period between 2/3/ 2019 to1/7/ 2019. Data collected from (450) mothers who have at least one child less
than(5)years of age,though using a special questionnaire format.
Results: The study finding out about (72.9%) of mothers participant were acceptable knowledge of measles
control and(24.4%) were poor knowledge while the(2.4%) have agood knowledge.
Conclusion:The study concluded most of mothers had been acceptable levels for knowledge. However,
educational program is still needed to increase the parents’ knowledge especially among illiterate and less
educated parents.
Performance Assessment of Mobile Laser Scanning Systems Using Velodyne Hdl-32e
Authors: Alsadik Bashar 
Published: January 2021

Mapping systems using multi-beam LiDARs are widely used nowadays for different geospatial applications graduating from indoor projects to outdoor city-wide projects. These mobile mapping systems can be either ground-based or aerial-based systems and are mostly equipped with inertial navigation systems INS. The Velodyne HDL-32 LiDAR is a well-known 360° spinning multi-beam laser scanner that is widely used in outdoor and indoor mobile mapping systems. The performance of such LiDARs is an ongoing research topic which is quite important for the quality assurance and quality control topic. The performance of this LiDAR type is correlated to many factors either related to the device itself or the design of the mobile mapping system. Regarding design, most of the mapping systems are equipped with a single Velodyne HDL32 in a specific orientation angle which is different among the mapping systems manufacturers. The LiDAR orientation angle has a significant impact on the performance in terms of the density and coverage of the produced point clouds. Furthermore, during the lifetime of this multi-beam LiDAR, one or more beams may be defected and then either continue the production or returned to the manufacturer to be fixed which then cost time and money. In this paper, the design impact analysis of a mobile laser scanning (MLS) system equipped with a single Velodyne HDL-32E will be clarified and a clear relationship is given between the orientation angle of the LiDAR and the output density of points. The ideal angular orientation of a single Velodyne HDL-32E is found to be at 35° in a mobile mapping system. Furthermore, we investigated the degradation of points density when one of the 32 beams is defected and quantified the density loss percentage and to the best of our knowledge, this is not presented in literature before. It is found that a maximum of about 8% point density loss occurs on the ground and 4% on the facades when having a defected beam of the Velodyne HDL-32E.
Antenatal care status of refugees: a tertiary center experience
Authors: SOYSAL Sunullah , KARAKUŞ Betül , TOPAL Esra , CANSIZ Cennet , BUDANCAMANAK Zeynep 
Published: January 2021

Aim: Refugees around the world is a major health problem. Lack of antenatal care among pregnant refuges may result in poor maternal and neonatal outcomes. In this study it was aimed to show current antenatal care status of refugees and evaluate intrapartum and postpartum features in a tertiary center in south west of Turkey.
Material and methods: Demographic, antenatal, peripartum and postpartum clinical features of 311 refugee women who gave birth in a tertiary hospital in Turkey are evaluated.
Results: Adolescent pregnancy was seen in 21.5% of refugees. Consanguineous marriage was seen in %14.1of women. Ninety nine percent of refugee pregnants didn’t have regular antenatal care. Cesarean section rate was 22.5% among refugee labors.
Conclusion: This study reveals that refugee women lack enough antenatal care. Although antenatal care is free and easily accessible in Turkey, refugee women don’t attend antenatal care programs. For this reason, refugee women should be educated and informed about the importance of antenatal care.