bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between proton pump inhibitors after percutaneous coronary intervention and risk of gastric cancer
Authors: Ng Andrew Kei-Yan , Ng Pauline Yeung , Ip April , Cheung Ka-Shing , Siu Chung-Wah 
Published: August 2021

BackgroundPrevious studies showing an association between chronic use of proton pump inhibitor (PPI) and gastric cancer are limited by confounding by indication. This relationship has not been studied in patients receiving PPI for prophylaxis, such as those undergoing percutaneous coronary intervention (PCI).MethodThis was a retrospective cohort study including 14 hospitals under the Hospital Authority of Hong Kong between 1 January 2004 and 31 December 2017. Participants were patients who underwent first-ever PCI, were not on PPI prescription within 30 days before admission for PCI, had no known malignancy and survived for 365 days after PCI. Propensity score matching was used to balance baseline characteristics and other prescription patterns. The primary outcome was diagnosis of gastric cancer made >365 days after PCI as a time-to-first-event analysis. The secondary outcome was death from gastric cancer.ResultsAmong the 13 476 patients (6738 pairs) matched by propensity score, gastric cancer developed in 17 (0.25%) PPI users and 7 (0.10%) PPI non-users after a median follow-up of 7.1 years. PPI users had a higher risk of gastric cancer (HR 3.55; 95% CI 1.46 to 8.66, p=0.005) and death from gastric cancer (HR 4.18; 95% CI 1.09 to 16.08, p=0.037), compared with non-users. The association was duration-dependent and patients who took PPI for ≥365 days were at increased risk.ConclusionsChronic use of PPI was significantly associated with increased risk of gastric cancer and death from gastric cancer in patients for whom it was prescribed as prophylaxis. Physicians should judiciously assess the relevant risks and benefits of chronic PPI use before prescription.
Role of locoregional surgery in treating FIGO 2009 stage IVB cervical cancer patients: a population-based study
Authors: Wang Yanhong , Ouyang Yi , Su Jingjing , Bai Zhigang , Cai Qunrong , Cao Xinping 
Published: August 2021

ObjectiveWe aimed to analyse the clinical value of primary site surgery in improving the cancer-specific survival (CSS) and overall survival (OS) of initial metastatic cervical cancer patients.DesignA population-based retrospective study.SettingNational Cancer Institute’s Surveillance, Epidemiology and End Results database.ParticipantsWe analysed 1390 patients with the International Federation of Gynecology and Obstetrics 2009 stage IVB cervical cancer with complete clinical data treated between 2010 and 2016.InterventionsPrimary site surgery.MeasuresPropensity score matching (PSM) with a ratio of 1:2 was used to balance measure covariates of comparison groups. Survival time was calculated using Kaplan-Meier methods and compared by the log-rank test. To eliminate the bias of site-specific metastasis, clinicopathological factors and subsequent therapy on survival analysis, subgroup analyses stratified by metastasis type, clinicopathological factors and subsequent therapy were employed to evaluate the effect of cervical surgery on survival. Combination of directed acyclic graph and change-in-estimate procedures was performed to indentified confounders, and Cox regression was used to assess the survival benefit of cervical surgery for primary metastatic cervical cancer patients. The consistency of our findings was evaluated through sensitivity analysis.ResultsMatching resulted in two comparison groups with minor differences in most variables. Pre-and-post-PSM, the median CSS and OS in the surgery group were 1.3 and 1.5, 1.1 and 1.2 times of those in the non-surgery group, respectively. Primary site surgery conferred prognosis superiority for patients with metastases to distant lymph node and other sites rather than organ metastases. After PSM and adjusting confounders, local surgery reduced the cancer related and overall mortality rates by 31% and 30%, respectively.ConclusionsSurgical procedures could promote survival in patients with primary metastatic cervical cancer and should be considered a therapeutic option for carefully chosen patients.
Assessing variation among the national essential medicines lists of 21 high-income countries: a cross-sectional study
Authors: Taglione Michael Sergio , Persaud Nav 
Published: August 2021

ObjectiveEssential medicines lists have been created and used globally in countries that range from low-income to high-income status. The aim of this paper is to compare the essential medicines list of high-income countries with each other, the WHO’s Model List of Essential Medicines and the lists of countries of other income statuses.DesignHigh-income countries were defined by World Bank classification. High-income essential medicines lists were assessed for medicine inclusion and were compared with the subset of high-income countries, the WHO’s Model List and 137 national essential medicines lists. Medicine lists were obtained from the Global Essential Medicines database. Countries were subdivided by income status, and the groups’ most common medicines were compared. Select medicines and medicine classes were assessed for inclusion among high-income country lists.ResultsThe 21 high-income countries identified were most like each other when compared with other lists. They were more like upper middle-income countries and least like low-income countries. There was significant variability in the number of medicines on each list. Less than half (48%) of high-income countries included a newer diabetes medicines in their list. Most countries (71%) included naloxone while every country including at least one opioid medicine. More than half of the lists (52%) included a medicine that has been globally withdrawn or banned.ConclusionEssential medicines lists of high-income countries are similar to each other, but significant variations in essential medicine list composition and specifically the number of medications included were noted. Effective medicines were left off several countries’ lists, and globally recalled medicines were included on over half the lists. Comparing the essential medicines lists of countries within the same income status category can provide a useful subset of lists for policymakers and essential medicine list creators to use when creating or maintaining their lists.
Association between television viewing and overweight and obesity among women of reproductive age in Timor-Leste: evidence from the demographic health survey 2016
Authors: Talukder Animesh , Das Gupta Rajat , Hashan Mohammad Rashidul , Haider Shams Shabab , Sajal Ibrahim Hossain , Sarker Malabika 
Published: August 2021

ObjectiveThis study aimed to assess the possible relationship between television viewing and overweight and obesity among Timorese women of reproductive age.MethodsThis cross-sectional study analysed the Timor-Leste Demographic and Health Survey 2016 dataset. A weighted sample of 11 398 Timorese women aged 15–49 years was chosen using a two-stage stratified random sampling technique. Asian criteria-based body mass index (BMI) cut-offs were used to define overweight (BMI 23.0 to <27.5 kg/m2) and obesity (BMI ≥27.5 kg/m2). Frequency of TV viewing was categorised into three groups: (1) not at all, (2) less than once a week and (3) at least once a week. Multilevel ordered logistic regression was performed to identify the correlates of overweight and obesity. Both crude and adjusted odds ratios (AOR) along with a 95% CI were calculated to show the strength of association.ResultsAmong 11 398 respondents, 19.4% were overweight or obese (overweight: 15.7% and obese: 3.8%). Although about half of the respondents reportedly did not watch TV at all, just over two-thirds watched TV at least once a week. Women who watched TV at least once a week were found to have 1.3 times the odds of being overweight or obese compared with those who never watched TV (AOR: 1.3, 95% CI: 1.1 to 1.5; p<0.001). However, when stratified by settlement type, the statistical significance stood for the rural women only (AOR: 1.5, 95% CI: 1.2 to 1.8; p<0.001), after adjusting for the covariates.ConclusionWatching TV at least once a week was found to be a significant correlate of overweight and obesity in rural Timorese women of reproductive age. Further studies need to be undertaken to assess physical activity, sedentary and dietary patterns to clarify the possible mechanism through which TV viewing may influence BMI in those groups.
Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis
Authors: Xiong Yilin , Zeng Chao , Doherty Michael , Persson Monica S M , Wei Jie , van Middelkoop Marienke , Lei Guanghua , Zhang Weiya 
Published: August 2021

IntroductionSymptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs). Treatment guidelines therefore have emphasised the need to identify predictors of treatment response through subgroup and multiple regression analysis. Individual participant data (IPD) meta-analysis is recommended as an efficient approach for this purpose. To our knowledge, this has not been undertaken for oral non-steroidal anti-inflammatory drugs (NSAIDs), including paracetamol, in OA. In this IPD meta-analysis, we aim to identify RCTs with specific mechanistic features related to OA pain, such as joint inflammation. We hypothesise that NSAIDs may work better for participants with joint inflammation, whereas paracetamol may not.Methods and analysisA comprehensive literature search will be conducted on the databases of Web of Science, Embase, Medline, CINAHL, AMED and the Cochrane Library from 1 January 1998 to 1 December 2020. All RCTs related to oral NSAIDs or paracetamol including placebo-controlled trials in people with OA that have evaluated pain-related peripheral risk factors (eg, clinically detected knee effusion, synovial hypertrophy or effusion on imaging, knee morning stiffness, elevated serum C-reactive protein (CRP) level) and/or central pain risk factors (eg, pain elsewhere, depression, anxiety, sleep disturbance) will be retrieved. The outcome will be change in pain from baseline. Change in function and patient global assessment will also be included as outcomes if available. Investigators of all eligible trials will be contacted for IPD. Multilevel regression models will be used to identify predictors for the specific (active–placebo) and the overall treatment effect (change from baseline in active group).Ethics and disseminationNo identifiable data will be included in this study and no formal ethics approval is required as no new data collection will be processed. Results of this hypothesis-driven IPD meta-analysis will be disseminated through conference presentations and publication in peer-reviewed journals.PROSPERO registration numberCRD42020165098.
High-intensity interval training or resistance training versus usual care in men with prostate cancer on active surveillance: a 3-arm feasibility randomized controlled trial
Authors: Papadopoulos Efthymios , Gillen Jenna , Moore Daniel , Au Darren , Kurgan Nigel , Klentrou Panagiota , Finelli Antonio , Alibhai Shabbir M.H. , Santa Mina Daniel 
Published: August 2021

This study assessed the feasibility of a phase II randomized controlled trial of high-intensity interval training (HIIT), resistance training (RT), and usual care (UC) in men with prostate cancer (PCa) on active surveillance and evaluated changes in clinically relevant outcomes. Eighteen men undergoing active surveillance for PCa were randomized to HIIT (n = 5), RT (n = 7), or UC (n = 6). Exercise participants attended 2 supervised sessions weekly and were instructed to complete 1 home-based session weekly for 8 weeks. UC participants were provided with physical activity guidelines. Feasibility was met for attendance, compliance, and retention, but not recruitment. HIIT increased leg press (mean: +8.2 kg, 95% CI 1.1 to 15.3) from baseline to 8 weeks. RT increased seated row (mean: +11.7 kg, 95% CI 6.1 to 17.3), chest press (mean: +10.4 kg, 95% CI 5.3 to 15.5), leg press (mean: +13.1 kg, 95% CI 5.9 to 20.3), serum insulin-like binding protein-3 (IGFBP-3) (mean: +400.0 ng/mL, 95% CI 94.5 to 705.5), and decreased interferon-γ (mean: −3.1 pg/mL, 95% CI −5.7 to −0.4). No changes were observed in the UC group. HIIT and RT may be effective strategies for improving muscle strength; however, only RT may increase serum IGFBP-3. Strategies that can enhance recruitment in men on active surveillance are important prior to conducting a phase II trial. Trial registration number: ClinicalTrials.gov number NCT04266262. Novelty: High-intensity interval training or resistance training are feasible during active surveillance for prostate cancer. Resistance training may suppress the tumour-promoting effects of insulin-like growth factor-I (IGF-I) via increased expression of IGFBP-3.
Tools for studying composite models
Authors: Panizzi Luca 
Published: August 2021

AbstractThis contribution provides an overview of available numerical tools for performing phenomenological studies related to the new physics predicted by composite scenarios. The overview focuses on model-independent constructions and aims at identifying the differences and connections between the implementations of numerical models, mostly focusing on the simplified-model approach. Attention is given to which kind of studies can be performed with such tools, with emphasis to the Higgs sector, new vector-like quarks and new bosonic states. A discussion of strategies for the analysis non-minimal simplified scenarios is also provided.
Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
Authors: Pham Elizabeth , Friedrich Matthias , Aeffner Famke , Lutteropp Michael , Mariano Natalie F. , Deegen Petra , Dahlhoff Christoph , Vogel Franziska , Bluemel Claudia , Harrold John M. , Brandl Christian , Grinberg Natalia , Rattel Benno , Coxon Angela , Bailis Julie M. 
Published: August 2021

Abstract
MUC12 is a transmembrane mucin that is highly expressed in &gt;50% of primary and metastatic colorectal tumors. MUC12 is also expressed by normal epithelial cells of the colon and small intestine. Although MUC12 localization in normal epithelial cells is restricted to the apical membrane, expression in tumors is depolarized and shows broad membrane localization. The differential localization of MUC12 in tumor cells as compared with normal cells makes it a potential therapeutic target. Here, we evaluated targeting of MUC12 with a BiTE (bispecific T-cell engager) molecule. We generated a panel of proof-of-concept half-life extended (HLE) BiTE molecules that bind MUC12 on tumor cells and CD3 on T cells. We prioritized one molecule based on in vitro activity for further characterization in vivo. In vitro, the MUC12 HLE BiTE molecule mediated T-cell–redirected lysis of MUC12-expressing cells with half-maximal lysis of 4.4 ± 0.9 to 117 ± 78 pmol/L. In an exploratory cynomolgus monkey toxicology study, the MUC12 HLE BiTE molecule administered at 200 μg/kg with a step dose to 1,000 μg/kg was tolerated with minimal clinical observations. However, higher doses were not tolerated, and there was evidence of damage in the gastrointestinal tract, suggesting dose levels projected to be required for antitumor activity may be associated with on-target toxicity. Together, these data demonstrate that the apically restricted expression of MUC12 in normal tissues is accessible to BiTE molecule target engagement and highlight the difficult challenge of identifying tumor-selective antigens for solid tumor T-cell engagers.
First records of Brazilian three-banded armadillo (Tolypeutes tricinctus, Mammalia, Cingulata, Chlamyphoridae) predation by jaguar (Panthera onca, Mammalia, Carnivora, Felidae)
Authors: Magalhães Rodolfo Assis , Sena Liana Mara Mendes de , Rodrigues Flávio Henrique Guimarães 
Published: August 2021

The jaguar Panthera onca and the Brazilian three-banded armadillo Tolypeutes tricinctus are two threatened mammals that coexist in the Caatinga dry forests and the Cerrado savannas of Brazil. Yet, to the best of our knowledge, interactions between these species have not been reported in the literature. Here, we present the first records of P. onca predation on T. tricinctus from two different areas in the Caatinga in northeastern Brazil. We showed that P. onca can pierce the hard carapace of T. tricinctus, which may be possible due to its distinctly strong bite and associated predation behavior. We argue that P. onca may be the most adapted non-human predator to feed on T. tricinctus, and that the smaller body sizes of P. onca individuals in the Caatinga may increase their likelihood to feed on smaller prey, including T. tricinctus. Thus, the originality of our records is probably more related to insufficient research in the areas where these species coexist than to the rarity of this interaction.
Characterization of shelters of the giant otter (Pteronura brasiliensis, Mammalia, Carnivora, Mustelidae) in the pantanal wetlands, state of Mato Grosso, Brazil
Authors: Damasceno Júnio de Souza , Shiraiwa Marília Couto Silva , Dalponte Júlio César 
Published: August 2021

The giant otter (Pteronura brasiliensis) is an endangered mammal that occupies aquatic environments, especially in the Amazon Rainforest and Pantanal wetlands in South America. The species uses shelters (dens and campsites), such as burrowed tunnels and tangles of branches and roots along watercourses, where it feeds mainly on fishes. In Espírito Santo Creek (northern portion of the Pantanal wetlands in the state of Mato Grosso, Brazil), 60 shelters (45 dens and 15 campsites) were identified and georeferenced during 12 fieldtrips between 2002 and 2003. The density was 1.8 dens/km. The shelters were significantly found in locations with partial (35%) or complete (55%) plant cover. The dens were dug mainly in soil associated with roots located, on average, 4.4 m in distance and 2.4 m in height in relation to the waterline. The campsites had a significantly smaller distance and height compared to the dens. The greater density of dens in the study area underscores the need for conserved environments with little human interference for the protection of giant otter populations. The vegetal coverage of riparian forests and the occurrence of ravines along Espírito Santo Creek offer greater protection to the shelters, hindering the access of predators to the interior of the shelter. Studies integrating biological and ecological knowledge with social participation in areas of occurrence of the giant otter are fundamental to the conservation of the species and its habitat in the Pantanal wetlands of Mato Grosso, Brazil.
35 years behind the scenes: range extension of the rare Gro’s manticore, Morunasaurus groi (Squamata, Hoplocercidae), in Colombia
Authors: Vásquez-Restrepo Juan Daniel 
Published: August 2021

Morunasaurus is a genus of Neotropical iguanid lizards of the family Hoplocercidae, inhabiting Central and northwestern South America. Their phylogenetic relationships are not completely clear but being presumably paraphyletic. Its type species, M. groi, is very rare, known only from two single localities and a handful of specimens. Here I report a new occurrence of this species for Colombia, which constitutes the southeastern record to the date, extending the species range by about 175 km and 510 m altitudinally. Additionally, I discuss about the intraspecific differences in coloration between Panamanian and Colombian specimens.
Redescription of the Neotropical species Trichodischia soror Bigot, 1885 (Diptera: Tachinidae), with a new generic synonymy
Authors: Alvarez-Garcia Deivys M. , Santis Marcelo Domingos de 
Published: August 2021

Trichodischia Bigot, 1885 is a Neotropical genus with a confusing taxonomic history. This was initially composed of two species: T. caerulea Bigot, 1885 and T. soror Bigot, 1885. Later, the genus Trichoraea Cortés, 1974 was erected for T. caerulea. When reviewing the taxonomic history of both species, we discovered that both genera have been considered synonymous based on erroneous information and without a formal synonymy being proposed. Herein, we redescribed T. soror, provide images of adults and describe the male terminalia for the first time. In addition, by examining the type material, we propose Trichoraea as a junior synonym of Trichodischia, syn. nov., confirm T. caerulea comb. rest. and T. soror as valid species and provide some comments about the taxonomy and host record of the genus.
First record and a new species of Euphrosynoplax (Crustacea: Pseudorhombilidae) from the southwestern Atlantic
Authors: Tavares Marcos Domingos Siqueira , Santana William Ricardo Amâncio 
Published: August 2021

A new species of deep-water brachyuran crab, Euphrosynoplax dincao, from southeastern Brazil is described and illustrated. The genus Euphrosynoplax currently consists of two species, E. clausa Guinot, 1969, and E. campechiensis Vázquez-Bader & Gracia, 1991, both only known from the Gulf of Mexico. The new species can be easily separated from its northern counterparts by a suite of carapace and appendage characters. Euphrosynoplax campechiensis is recorded for the first time from the Caribbenan Sea (Guadeloupe and between Saint Kitts and Nevis).
Report of an extra-pair copulation in the Rufous Hornero, Furnarius rufus (Aves: Furnariidae)
Authors: Diniz Pedro , Biagolini-Jr. Carlos 
Published: August 2021

In the last decade, studies in bird breeding biology have shown that infidelity is prevalent in socially monogamous species. Here, we describe an extra-pair copulation (EPC) event in the Rufous Hornero (Furnarius rufus), a socially monogamous bird with year-round territoriality and low levels of extra-pair paternity. Before the EPC, a within-pair copulation (WPC) occurred inside the pair’s territory. The WPC occurred on the ground and between a banded male (ca. 6 years-old) and an unbanded female. Ten minutes later this breeding pair invaded a neighboring territory, presumably to forage. The territorial male was chased back to its territory by an unbanded male neighbor after being detected. The male neighbor was paired with an unbanded female that did not participate in the aggressive interaction. When flying back to its territory the male neighbor copulated with the territorial female on the ground (ie. EPC). The territorial male flew, vocalized, and perched above the male neighbor, interrupting the EPC. The aggressive interaction then ceased as each pair resumed foraging in their respective territories. These observations suggest that Rufous Horneros can use EPC to obtain immediate benefits (food access in a neighbor’s territory). Moreover, WPC may be detected by neighbors and physical mate guarding and/or frequent WPC may be necessary to prevent EPC in the Rufous Hornero.
A new species and synonymy in Atrypanius Bates (Coleoptera, Cerambycidae, Lamiinae) from the Brazilian Amazon forest
Authors: Santos-Silva Antonio 
Published: August 2021

Atrypanius jauffreti sp. nov. is described from Brazil (Pará). Nyssodrys grisella Bates, 1864 (currently, Atrypanius grisellus) is synonymized with Lepturges lineatocollis Bates, 1863 (currently, Atrypanius lineatocollis), and the species is recorded for the Brazilian states of Rondônia and Mato Grosso.