bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overview of Chemistry Teaching Transformation during COVID-19 Pandemic: An Experience from University of Botswana
Authors: S. Singh Girija 
Published: October 2021

COVID-19-related disruption in teaching in the University of Botswana led the school to prepare new strategies for running classes and to design innovative way of instruction. The most notable change was to replace face-to-face lectures with online teaching at least partially (blended teaching and learning). This posed many challenges, especially in the teaching of science and technology subjects. In a laboratory-based discipline such as chemistry the problems encountered were especially daunting. Moreover, writing mathematical equations, chemical reactions and reaction mechanisms posed their own difficulties. The present communication provides a brief overview of how chemistry education at the University, the premier national university of Botswana, has been transformed during the last three semesters. It is based on experience of the author and as judged by the feed-back received from colleagues and the students. Admittedly, the experience is limited and much discussion is still in progress to meet the unresolved challenges. Theory classes at undergraduate levels are now mostly taught online using packages such as Moodle and MS Teams. The tutorial and laboratory sessions have faced the greatest disruptions and the instructors continue to explore ways to conduct these virtually. Online examinations were found to be limited in their effectiveness, especially in the assessment of drawing chemical structure and reaction mechanisms as well as the students’ ability in scientific writing.
Nursing Skill and Responsibility in Administration of Low Molecular Weight Heparin by Prefilled Syringe
Authors: Tembhare Vaishali , Mujbaile Gaurav , Singh Seema , Sawarkar Achita , Shambharkar Maduri , Sakharwade Prerana 
Published: October 2021

Abstract: Low-molecular-weight heparins (LMWHs) have proven to be effective in the prevention and treatment of thrombotic disorders, as well as substitute for unfractionated heparin (UFH). LMWHs are a diverse collection of medicines with different biochemical and pharmacological characteristics, despite the fact that they all have antithrombotic actions. Medicine is administered into the subcutaneous tissues with these injections. Small amounts of injections are delivered by the subcutaneous approach, which involves inserting a small thin needle beneath the skin and slowly injecting the medicine. Low molecular weight heparins make up dalteparin and enoxaparin, two anticoagulants. The rights of medicine administration must be followed by nurses. For patients on LMWH medication, the most essential blood test is prothrombin time. Following administration, look for any signs of bleeding, such as occult blood in the stool, malena, bleeding gums, and skin discoloration/hematoma. The antidote for low molecular weight heparin is protamine sulphate. It is effective at counteracting the effects of LMWH. 100 units of LMWH are neutralised by 1 mg of protamine sulphate.If it's been more than 8 hours since you've given LMWH, provide 0.5 mg protamin per 100 units of LMWH.
Segredos e ‘verdades’ acerca da condição intersexual em Grey’s Anatomy
Authors: Siqueira Silva Luciana Aparecida , Santos Claudiene , Da Silva Laíne Lopes , Silva Elenita Pinheiro de Queiroz 
Published: October 2021

O binômio do sexo é uma obsessão do Ocidente. Esta é uma afirmação de Paul Beatriz Preciado em uma entrevista que concede em 2008. Com ela, analisamos como a condição intersexual e as pessoas intersexo são apresentadas em dois episódios da série Grey’s Anatomy. Perguntamos pelos discursos mobilizados nas narrativas dos episódios e pelo protagonismo ou invisibilidade e apagamento das vozes dos corpos intersexos. Ainda nos interessamos pelos ensinamentos da série sobre estes corpos. Encontramos a reiteração da heteronormatividade, a exploração das relações afetivas, o discurso médico, o diagnóstico e o segredo que guardam o corpo intersexo. Estes últimos, são usados como mecanismos de funcionamento do binômio do sexo e da produção de identidade de gênero e corpos ‘normais’, via família e medicina, que fazem acordos de silêncio quanto à adequação dos corpos a uma inteligibilidade de gênero alinhada ao sexo. A série transita mais no polo da ordem do que da desordem.
Hydrolytically Degradable Poly(β‐amino ester) Resins with Tunable Degradation for 3D Printing by Projection Micro‐Stereolithography
Authors: Muralidharan Archish , McLeod Robert R. , Bryant Stephanie J. 
Published: October 2021

AbstractApplications of 3D printing that range from temporary medical devices to environmentally responsible manufacturing will benefit from printable resins that yield polymers with controllable architecture, material properties, and degradation behavior. Towards this goal, poly(β‐amino ester) (PBAE)‐diacrylate resins are investigated due to the wide range of available chemistries and tunable material properties. PBAE‐diacrylate resins are synthesized from hydrophilic and hydrophobic chemistries and with varying electron densities on the ester bond to provide control over degradation. Hydrophilic PBAE‐diacrylates led to degradation behaviors characteristic of bulk degradation, while hydrophobic PBAE‐diacrylates led to degradation behaviors dominated initially by surface degradation and then transitioned to bulk degradation. Depending on the chemistry, the crosslinked PBAE‐polymers exhibited a range of degradation times under accelerated conditions, from complete mass loss in 90 min to minimal mass loss at 45 days. Patterned features with 55 µm resolution are achieved across all resins, but their fidelity is dependent on PBAE‐diacrylate molecular weight, reactivity, and printing parameters. In summary, simple chemical modifications in the PBAE‐diacrylate resins coupled with projection microstereolithography enable high‐resolution 3D printed parts with similar architectures and initial properties but widely different degradation rates and behaviors.
Lectin‐Functionalized Polyethylene Glycol for Relief of Mucosal Dryness
Authors: Blakeley Matthew , Sharma Prashant K. , Kaper Hans J. , Bostanci Nagihan , Crouzier Thomas 
Published: October 2021

AbstractThe importance of lubrication between oral surfaces provided by the salivary film is most acutely apparent when it is disrupted, a prevalent consequence of salivary gland hypofunction experienced with aging, a symptom of certain diseases, or a side effect of some medical interventions. Sufferers report difficulty with speech and oral food processing and collectively is detrimental to quality of life. Polyethylene glycol (PEG) is widely employed as a successful biocompatible boundary lubricant in engineering and biomedical applications. It is hypothesized that the immobilization of PEG to biological materials such as oral epithelial cells and tissue can mimic the salivary film and provide durable relief from the symptoms of mucosal dryness. To do so, PEG is functionalized with a sugar binding lectin (wheat germ agglutinin) to enhance epithelial adhesion through lectin‐sugar interactions. Retention and lubricity are characterized on an ex vivo oral tissue tribology rig. WGA‐PEG coats and retains on mucin films, oral epithelial cells, and porcine tongue tissue, and offers sustained reduction in coefficient of friction (COF). WGA‐PEG could be developed into a useful topical treatment for reducing oral friction and the perception of dry mouth.
Multicolor Photonic Pigments for Rotation‐Asymmetric Mechanochromic Devices
Authors: Li Zhiwei , Wang Xiaojing , Han Lili , Zhu Chenhui , Xin Huolin , Yin Yadong 
Published: October 2021

AbstractPhotonic crystals are extensively explored to replace inorganic pigments and organic dyes as coloring elements in printing, painting, sensing, and anti‐counterfeiting due to their brilliant structural colors, chemical stability, and environmental friendliness. However, most existing photonic‐crystal‐based pigments can only display monochromatic colors once made, and generating multicolors has to start with designing different building blocks. Here, a novel photonic pigment featuring highly tunable structural colors in the entire visible spectrum, made by the magnetic assembly of monodisperse nanorods into body‐centered‐tetragonal photonic crystals, is reported. Their prominent magnetic and crystal anisotropy makes it efficient to generate multicolors using one photonic pigment by magnetically controlling the crystal orientation. Further, the combination of angle‐dependent diffraction and magnetic orientation control enables the design of rotation‐asymmetric photonic films that display distinct patterns and encrypted information in response to rotation. The efficient multicolor generation through precise orientational control makes this novel photonic pigment promising in developing high‐performance structural‐colored materials and optical devices.
Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene‐Related Peptide
Authors: Mi Jie , Xu Jian‐Kun , Yao Zhi , Yao Hao , Li Ye , He Xuan , Dai Bing‐Yang , Zou Li , Tong Wen‐Xue , Zhang Xiao‐Tian , Hu Pei‐Jie , Ruan Ye Chun , Tang Ning , Guo Xia , Zhao Jie , He Ju‐Fang , Qin Ling 
Published: October 2021

AbstractThe neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited. Here it is shown that electrical stimulation (ES) directly promotes the biosynthesis and release of calcitonin gene‐related peptide (CGRP) by activating Ca2+/CaMKII/CREB signaling pathway and action potential, respectively. To accelerate rat femoral osteoporotic fracture healing which presents with decline of CGRP, soft electrodes are engineered and they are implanted at L3 and L4 dorsal root ganglions (DRGs). ES delivered at DRGs for the first two weeks after fracture increases CGRP expression in both DRGs and fracture callus. It is also identified that CGRP is indispensable for type‐H vessel formation, a biological event coupling angiogenesis and osteogenesis, contributing to ES‐enhanced osteoporotic fracture healing. This proof‐of‐concept study shows for the first time that ES at lumbar DRGs can effectively promote femoral fracture healing, offering an innovative strategy using bioelectronic device to enhance bone regeneration.
The potential impact of reducing sodium in packaged food: The case of the Chinese instant noodles market
Authors: Chen Yu , Zhen Chen 
Published: October 2021

AbstractReducing sodium intake has been identified as a priority and cost‐effective intervention in lowering the risk of hypertension and cardiovascular diseases. To accomplish the population‐wide sodium reduction, two main strategies regarding food supply have been widely discussed: one is to set mandatory standards for the sodium content of foods and the other is to call for efforts from the food industry to voluntarily reduce sodium. Using the Chinese instant noodles market as an example, we estimate a random‐coefficients logit demand model to quantify the degree of substitution between competing products and between sodium and fat. The demand estimates are then used to simulate three sodium reduction strategies: a unilateral reduction by one firm, and industry‐wide reductions by multiple firms with and without reformulation of fat content. We find that voluntarily sodium reduction by a single firm results in its sales loss to its competitors; an industry‐wide sodium reduction causes demand reduction to be more evenly distributed across participating firms; and an industry‐wide reduction accompanied by an increase in fat content largely negates the adverse effect of sodium reduction on sales but risks an increase in population fat intake. [EconLit Citations: D12; I18; L66].
Composition design ofPLA/TPUemulsion blends compatibilized with multifunctional epoxy‐based chain extender to tackle high impact resistant ductile structures
Authors: Kahraman Yusuf , Alkan Goksu Yonca , Özdemir Burcu , Eker Gümüş Beril , Nofar Mohammadreza 
Published: October 2021

AbstractIn this study, the composition of polylactide (PLA)/thermoplastic polyurethane (TPU) emulsion blends compatibilized with multifunctional epoxy‐based Joncryl chain extender was regulated to tackle high impact resistant structures with improved ductility. PLA/TPU blends at different blending ratios of 95wt/05wt, 85wt/15wt, 75wt/25wt, and 65wt/35wt were first melt blended with 0.5 wt% of Joncryl. In all compositions, although the TPU droplets were significantly refined with the addition of Joncryl, the impact strength and ductility of the blends increased dramatically only at 75wt/25wt and 65wt/35wt blending ratios. The 75wt/25wt blend was then melt blended with various Joncryl contents of 0.25, 0.5, 0.75, and 1.0 wt%. It was illustrated that 0.5 wt% Joncryl was high enough to reach a blend with the highest impact strength and ductility of around 110 kJ/m2and 150%, respectively. This was while the tensile strength and modulus values remained comparable with those of neat PLA. The rheological experiments and the dynamic mechanical analysis confirmed that the complex viscosity and the storage modulus of the compatibilized blends were improved as a result of increased melt strength of PLA and the interfacial compatibilization through using Joncryl.
Green synthesis of novel antifungal 1,2,4‐triazoles effective against γ‐irradiated Candida parapsilosis
Authors: El‐Hazek Reham M. , Elkenawy Nora M. , Zaher Nashwa H. , El‐Gazzar Marwa G. 
Published: October 2021

AbstractThis study reports the green synthesis of 11 novel 3‐substituted‐4‐amino‐5‐mercapto‐1,2,4‐triazole derivatives using water as a readily available nontoxic solvent. Evaluation of their antimicrobial potential against several clinical pathogenic microorganisms was carried out. The newly synthesized cysteine derivative 6 showed promising antifungal activity against both γ‐irradiated and nonirradiated Candida parapsilosis 216, with the lowest MIC (minimum inhibitory concentration) value of 3.125 µg/ml, probably through inhibition of 14α‐demethylase. In addition, compound 6 showed complete inhibition of gelatinase, a virulence enzyme of C. parapsilosis. Also, scanning electron microscopy was carried out. Interestingly, compound 6 acted as a dual agent as it also showed good antibacterial activity against strains of Gram‐positive bacteria used in the study. The synthesized compounds showed no cytotoxicity.
Asymptomatic detection of SARS‐CoV‐2 among cancer patients receiving infusional anti‐cancer therapy
Authors: Shaya Justin , Cabal Angelo , Nonato Taylor , Torriani Francesca , Califano Joseph , Lippman Scott , Sacco Assuntina , McKay Rana R. 
Published: October 2021

AbstractBackgroundLittle is known regarding the rate and clinical outcomes of asymptomatic carriers of SARS‐CoV‐2 among patients with cancer. Detection of asymptomatic carriers is important in this population given the use of myelosuppressive and immunomodulating therapies. Understanding the asymptomatic carrier rate will help to develop mitigation strategies in this high‐risk cohort.MethodsRetrospective cohort analysis of an asymptomatic screening protocol which required patients receiving infusional anti‐cancer therapy to undergo a symptom/exposure screen and SARS‐CoV‐2 PCR testing 24–96 h prior to their infusion. The primary outcome of this analysis was the rate of asymptomatic SARS‐CoV‐2 infection. Secondary outcomes included the rate of COVID‐19‐related hospitalization and mortality and delays in oncologic therapy.ResultsAmong a cohort of 2691 cancer patients who underwent asymptomatic screening, 1.6% (N = 43/2691) of patients were found to be SARS‐CoV‐2 positive on asymptomatic screening. 11.6% (N = 5/43) of the cohort ultimately developed COVID‐19‐related symptoms. Four patients required hospitalization for complications of COVID‐19 infection. No patient died from COVID‐related complications. 97.7% (N = 42/43) had their anti‐cancer therapy delayed or deferred with a median delay of 21 days (range: 7–77 days).ConclusionsOverall, among a cohort of active cancer patients receiving anti‐cancer therapy, an asymptomatic SARS‐CoV2 PCR‐based screening protocol detected a small cohort of asymptomatic carriers. The majority of these patients remained asymptomatic on long‐term follow‐up and outcomes were much more favorable compared to previously described outcomes of cancer patients with symptomatic COVID‐19 infection.
“At What Cost am I Doing This?” An interpretative phenomenological analysis of the experience of burnout among private practitioner psychotherapists
Authors: Finan Stephanie , McMahon Aisling , Russell Siobhán 
Published: October 2021

AbstractBurnout is an experience in response to chronic job stressors, understood to be composed of three components: exhaustion, cynicism and inefficacy. Burnout is an occupational hazard among psychotherapists that may result in poorer quality of care for clients and a diminished quality of life for clinicians. Several quantitative studies have shown that psychotherapists are at risk of developing burnout given the demanding nature of their work. While much research has been carried out with psychotherapists who work in organisations, there is a lack of available literature concerning the experience of the psychotherapy practitioner working in private practice. This study aimed to gain an understanding of psychotherapists’ lived experiences of burnout while working exclusively in private practice in Ireland. Eight semi‐structured interviews were conducted and analysed using interpretative phenomenological analysis. Three superordinate themes were identified: (a) A Professional Identity Crisis: “maybe I just don't have what it takes?”; (b) The Embodiment of Burnout: “constantly running on red”; and (c) The Process of Rebalancing: “being real”. The participants revealed a disillusionment with their career, alongside self‐criticism and shame for not meeting their internalised standards. They illuminated a profound felt sense of depletion and physical unwellness. They also shared their ongoing process of rebalancing rather than recovery from burnout. Participants universally described difficulty identifying and articulating burnout. The findings are discussed with reference to identity, embodiment of burnout and the process of rebalancing.
ACGME Interventional Cardiology Milestones 2.0–an overview: Endorsed by the Accreditation Council for Graduate Medical Education
Authors: Ijioma Nkechinyere N. , Don Creighton , Arora Vishal , Edgar Laura , Hawkins Beau , Monteleone Peter , Tcheng James E. , Helmy Tarek 
Published: October 2021

AbstractThis document provides an overview of the rationale, development, interpretation, and practical suggestions for implementation of the new Accreditation Council for Graduate Medical Education (ACGME) Interventional Cardiology (IC) Milestones 2.0. Previously, IC programs used the general ACGME Milestones for internal medicine. The IC Milestones version 2.0 updates the ACGME competencies to be specific to training in IC. In 2019 an ACGME working group consisting of IC program directors, a lay representative, and representatives from the American Board of Internal Medicine met to develop the IC Milestones version 2.0. The ACGME IC Milestones 2.0 establishes a framework for formative feedback for trainees within domains of patient care, medical knowledge, systems‐based practice, practice‐based learning and improvement, professionalism, and interpersonal and communication skills. The 2021 IC Milestones 2.0 provides a framework for IC mentors and trainees to identify areas for improvement or commendation help stimulate meaningful educational discussions, and provide the basis for self‐reflection and self‐improvement.
Endobronchial carcinoid presenting as Focal bronchiectasis in a young woman with systemic lupus erythematosus
Authors: Nasir Noreen , Akhlaq Safia , Shehzad Talha , Fatimi Saulat 
Published: October 2021

AbstractNon‐resolving pulmonary symptoms in a patient with SLE require evaluation to exclude rare pulmonary lesions, such as carcinoid tumors.
A case report of prostate adenocarcinoma with leptomeningeal carcinomatosis and intracerebral metastasis
Authors: Fazilat‐Panah Danial , Ahmadi Nahid , Moslemi Dariush , Karimi Masoumeh , Taji Alireza , Dehghani Mansoureh , Emadi Torghabeh Ali , Keshtpour Amlashi Zahra , Saghafi Mohammadreza , Fatemi Maedeh Alsadat 
Published: October 2021

AbstractDespite the fact that prostate cancer is the most prevalent cancer in men, metastases to the central nervous system including leptomeningeal involvement by prostate carcinoma is a rare event. The prognosis of metastatic prostate cancer is very poor due to lack of CNS penetrating therapeutic agents.
Extrahepatic biliary obstruction secondary to metastatic esophageal squamous cell carcinoma: An unusual presentation of Courvoisier's law
Authors: Atiba Kafi , Ramdass Michael , Oladiran Adedapo , Rahman Muhammad 
Published: October 2021

AbstractCourvoisier's law states, “In the presence of jaundice and a palpable bladder, the cause is unlikely to be due to stone”. Although esophageal squamous carcinoma is known to spread to celiac nodes, there is no description in the literature with it presenting and mimicking the above findings in Courvoisier's Law.
Kikuchi‐Fujimoto disease: A rare case report from Nepal
Authors: Rauniyar Rahul , Acharya Kshitiz , Mishra Aman , Pathak Nibesh , Chaudhary Gajendra , Bhandari Puja , Gaire Prabin 
Published: October 2021

AbstractClinicians and pathologists must be aware of the occurrence of Kikuchi‐Fujimoto Disease, as one of the differential diagnoses of cervical lymphadenopathy.
With lactase and lactose to electric current – enzymatic biofuel cell based on filter paper for chemistry lessons
Authors: Grandrath Rebecca , Bohrmann‐Linde Claudia 
Published: October 2021

AbstractBiologische Brennstoffzellen sind aktuell in Theorie und Praxis des schulischen Chemieunterrichts stark unterrepräsentiert. Es wird nachfolgend ein Schulversuch zu einer enzymatischen Brennstoffzelle im Kurzportrait vorgestellt. Dieses ist einfach und schnell aufzubauen und liefert reproduzierbar didaktisch prägnante Ergebnisse, die ein qualitatives Erschließen der Funktionsweise erlauben. Der Aufbau besticht durch die Verwendung kostengünstiger Materialien wie Filterpapierstreifen, Aktivkohle, Tensid, Lactase(‐Tabletten) und Lactose.