bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory Aspects of Personalised Medicines
Authors: Dhingra Ishita , Mani Neel , Thakkar Arti R. 
Published: February 2021

:
The advent of big data analysis, genetic engineering and epigenetics has transformed the
healthcare system by shifting the strategy for diagnosis, prevention and treatment of diseases from
“one-size-fits-all” approach to “personalised” approach. Identification of biomarkers from molecular
diagnosis has made tailoring of the medical treatment possible. Optimization of treatment decreases
the costs related to the ineffective treatments and helps in avoiding possible side effects
and adverse drug reactions. The efficient development of personalised medicine is largely dependent
on the tools, sequencing techniques used and regulatory policies related to the personalised
medicine products, tests and companion diagnostics. The uncertainties in the regulations governing
personalised medicine should be eliminated and specific guidelines should be laid down by the respective
regulatory authorities to bridge the emerging tools and technologies with the regulatory
policies. Also, proper regulatory approval pathways for companion diagnostics will resolve the
complications of organized development of therapeutic products and diagnostic tests.
Design Guidelines of a Computer-Based Intervention for Computer Vision Syndrome: Focus Group Study and Real-World Deployment
Authors: Hwang Youjin , Shin Donghoon , Eun Jinsu , Suh Bongwon , Lee Joonhwan 
Published: February 2021

Background
Prolonged time of computer use increases the prevalence of ocular problems, including eye strain, tired eyes, irritation, redness, blurred vision, and double vision, which are collectively referred to as computer vision syndrome (CVS). Approximately 70% of computer users have vision-related problems. For these reasons, properly designed interventions for users with CVS are required. To design an effective screen intervention for preventing or improving CVS, we must understand the effective interfaces of computer-based interventions.

Objective
In this study, we aimed to explore the interface elements of computer-based interventions for CVS to set design guidelines based on the pros and cons of each interface element.

Methods
We conducted an iterative user study to achieve our research objective. First, we conducted a workshop to evaluate the overall interface elements that were included in previous systems for CVS (n=7). Through the workshop, participants evaluated existing interface elements. Based on the evaluation results, we eliminated the elements that negatively affect intervention outcomes. Second, we designed our prototype system LiquidEye that includes multiple interface options (n=11). Interface options included interface elements that were positively evaluated in the workshop study. Lastly, we deployed LiquidEye in the real world to see how the included elements affected the intervention outcomes. Participants used LiquidEye for 14 days, and during this period, we collected participants’ daily logs (n=680). Additionally, we conducted prestudy and poststudy surveys, and poststudy interviews to explore how each interface element affects participation in the system.

Results
User data logs collected from the 14 days of deployment were analyzed with multiple regression analysis to explore the interface elements affecting user participation in the intervention (LiquidEye). Statistically significant elements were the instruction page of the eye resting strategy (P=.01), goal setting of the resting period (P=.009), compliment feedback after completing resting (P<.001), a mid-size popup window (P=.02), and CVS symptom-like effects (P=.004).

Conclusions
Based on the study results, we suggested design implications to consider when designing computer-based interventions for CVS. The sophisticated design of the customization interface can make it possible for users to use the system more interactively, which can result in higher engagement in managing eye conditions. There are important technical challenges that still need to be addressed, but given the fact that this study was able to clarify the various factors related to computer-based interventions, the findings are expected to contribute greatly to the research of various computer-based intervention designs in the future.
Matching-adjusted indirect comparison of palbociclib versus ribociclib and abemaciclib in hormone receptor-positive/HER2-negative advanced breast cancer
Authors: Rugo Hope S , Haltner Anja , Zhan Lin , Tran Anh , Bananis Eustratios , Hooper Becky , Mitra Debanjali , Cameron Chris 
Published: February 2021

Aim:
Palbociclib (PAL), ribociclib (RIB) and abemaciclib (ABM), in combination with fulvestrant (FUL), are approved for the treatment of hormone receptor-positive, HER2-negative advanced breast cancer. This study aims to determine relative efficacy of PAL+FUL versus RIB+FUL and ABM+FUL using matching-adjusted indirect treatment comparisons.
Patients & methods:
Anchored matching-adjusted indirect treatment comparisons were conducted using individual patient data from PALOMA-3 and published summary-level data from MONARCH 2 and MONALEESA-3. The primary outcome was overall survival (OS).
Results:
OS was similar for PAL+FUL versus ABM+FUL (hazard ratio: 0.87; 95% CI: 0.54–1.40) and RIB+FUL (hazard ratio: 0.89; 95% CI: 0.48–1.63).
Conclusion:
Adjusting for cross-trial differences suggests similar OS between treatments, underscoring the importance of accounting for these differences when indirectly comparing treatments.
SARS-CoV-2 en aguas residuales y superficiales: ¿cómo lidiar con el problema?
Authors: Rodríguez Rodríguez Yaset , Regla Rosa Domínguez Elena , Jauregui-Haza Ulises , Boluda Carlos José , Rodríguez de Francisco Luis Enrique 
Published: February 2021

Introducción: hoy la humanidad sufre uno de los peores episodios debido a la pandemia causada por el SARS-CoV-2. Su alta infectividad, rápida propagación y persistencia en ciertas superficies dificultan el combate de este virus. Su presencia en aguas residuales y posible transmisión fecal-oral podría ser una nueva amenaza para la salud pública.
Objetivo: alertar a la comunidad científica internacional y a los gobiernos sobre la presencia de SARS-CoV-2 en las aguas residuales y sobre qué hacer para evitar su propagación por este medio.
Métodos: se realizó una revisión de artículos referenciados en SCOPUS y Web of Science desde el año 2019 relacionados con la presencia del virus en aguas residuales y superficiales.
Resultados y discusión: es necesario establecer sistemas de monitoreo, utilizar métodos analíticos sensibles y rápidos para la detección del virus en las aguas residuales y superficiales. Asimismo, implantar protocolos de inactivación del virus en las unidades de salud y en las plantas de tratamiento de aguas. Se recomiendan procesos con oxidantes químicos, radiación ultravioleta, fotocatálisis, foto-Fenton, ozono o filtración por membrana. Además, se debe alertar a la población sobre la importancia del lavado y de la desinfección de productos agrícolas, así como del cuidado en su manejo por parte de los trabajadores agrícolas.
Relación entre nivel del antígeno prostático específico y hallazgos gammagráficos en el cáncer de próstata, Instituto de Oncología Doctor Heriberto Pieter, enero-junio 2018
Authors: Arias Rodríguez Samuels , Capellan Mata Cinthia Lisbeth , Díaz Mora Carlene 
Published: February 2021

Se realizó un estudio relacional, transversal y de fuente retrospectiva de la información, cuyo objetivo fue determinar la relación entre el nivel del antígeno prostático específico y hallazgos gammagráficos en el cáncer de próstata, Instituto de Oncología Dr. Heriberto Pieter. El universo estuvo conformado por 262 pacientes diagnosticados con cáncer de próstata y la muestra por 216 pacientes, representando un 82,4 %. Para la recolección de los datos se utilizó un formulario con ocho preguntas a partir de las variables de estudio. Los resultados mostraron que 69,4 % de los pacientes evidenciaron una relación entre el nivel de antígeno prostático específico y la gammagrafía ósea. El grupo etario más afectado con cáncer de próstata fue mayor de 75 años. 46,5 % de los pacientes con metástasis ósea mostraron un nivel de PSA mayor o igual a 100 ng/mL. Los principales focos metastásicos fueron columna lumbosacra y la pelvis con 24,3 y 20,7 % de metástasis, respectivamente. La escala de Gleason más frecuente en pacientes metastásico fue siete, mientras que en los no metastásico fue menor o igual a seis con 53,8 %
Penerapan Model Pembelajaran Kooperatif Tipe Think Pair and Share untuk Meningkatkan Prestasi Belajar Matematika Siswa Kelas IV Sekolah Dasar
Authors: Suwela I Ketut 
Published: February 2021

PenelitianinidilatarbelakangiolehrendahnyahasilbelajarPendidikanMatematikasiswakelas IVSekolahDasarNegeri 1 Sukadana.Sebagianbesarsiswabelummencapaiketuntasan minimal padapelajaranpendidikanMatematika.PenelitianinibertujuanuntukmeningkatkanhasilbelajarPendidikanMatematikasiswakelas IVSekolahDasarNegeri 1 Sukadanadenganpenerapanpembelajarankooperatiftipe think pair and share.PenelitianinimerupakanPenelitianTindakanKelas (PTK),yang dilaksanakandalam 2 siklus.Subyekdalampenelitianinisiswakelas IVSekolahDasarNegeri 1 Sukadanatahunpelajaran 2019/2020 sebanyak 30orang.Analisis data dalampenelitianinimenggunakandeskriftifkuantitatif .Hasilpenelitianmenunjukkanhasilbelajarsiswapadasiklus I skor rata-rata hasilbelajardengankategorirendah. Nilai rata-rata hasilbelajarsiswapadasiklus I yaitu64,83denganketuntasanklasikal64,83%, dayaserap 70 %.Kemudianpadasiklus II mengalamipeningkatan ,rata-rata hasilbelajarmenjadi 75,33 ketuntasanklasikalmenjadi 75,33 % dandayaserapmenjadi 100 %. Dan hasilanalisishasilbelajarsiklus I dan II mengalamipeningkatannilai rata-rata hasilbelajarsebesar 10,5 ketuntasanklasikalsebesar 30% dayaserapsebesar 10,5 % denganpenerapanpembelajarankooperatiftipe think pair and share.Berdasarkanhasilpenelitianinidapatdisimpulkanpenerapanpembelajarankooperatiftipe think pair and sharedapatmeningkatkanprestasibelajarPendidikanMatematika. Diajukan saran kepadapihakterkaitsebagaiberikut Peneliti lain diharapkanmengadakanpenelitianlanjutanterkaitdenganpenerapan model pembelajaran yang inovatif.
Kepemimpinan Lurah Terhadap Pemberdayaan Masyarakat Di Kelurahan Lautang Benteng Kabupaten Sidenreng Rappang
Authors: Mustanir Ahmad , Samad Zainuddin , Jabbar Abdul , Ibrahim Monalisa , Juniati Juniati 
Published: February 2021

Tujuan penelitian ini untuk mengetahui kepemimpinan lurah terhadap pemberdayaan masyarakat di Kelurahan Lautang Benteng Kecamatan Maritengngae Kabupaten Sidenreng Rappang. Tipe penelitian deskriptif kuantitatif. Sampel dalam penelitian yaitu 96 orang masyarakat dengan teknik purposive sampling menggunakan rumus Slovin. Pengumpulan data dilakukan melalui observasi dan kuesioner. Data yang ada dianalisis melalui tabel frekuensi menggunakan skala likert dan dilakukan metode analisis regresi linear sederhana melalui pengolahan SPSS 22.0. Hasilnya memperlihatkan bahwa: Kepemimpinan Lurah sebesar 45,17% termasuk dalam kategori cukup baik; Pemberdayaan Masyarakat sebesar 39,6% termasuk dalam kategori kurang baik; dan penelitian memperlihatkan kepemimpinan lurah berpengaruh terhadap pemberdayaan masyarakat. Ini dibuktikan melalui dengan perolehan output data dari tabel summary R2, kepemimpinan lurah memiliki pengaruh 13,3% terhadap pemberdayaan masyarakat sedangkan sisanya 86,7% dimungkinkan dipengaruhi oleh variabel lain diluar kerangka penelitian.
Psychological Impact of the COVID-19 Pandemic on Nurses Employed by the Palestinian Ministry of Health in Gaza
Authors: Radwan Abdalkarim Said 
Published: February 2021

Introduction: Coronaviruses hit the world at the end of 2019, but the first two cases inGaza Strip were diagnosed on 21 March in the quarantine centers. Nurses working with infected or suspected cases are at high risk to get the disease which may generate anxiety among them. Therefore, this study aimed to assess the psychological impact of COVID-19 pandemic on Palestinian nurses employed by the Palestinian Ministry of Health in Gaza Strip, Palestine.
Materials and methods: A toal of 424 nurses completed an online questionnaire packet that included demographic data and the 7-item Generalized Anxiety Disorder Scale (GAD-7).
Results: Results from this study revealed that while only 22.4% of the participants worked at quarantine centers designated to take care of infected/suspected cases of COVID-19, but a huge number of them (77.6%) got in direct contact with infected people. Variant levels of anxiety were reported by participants with 35.4% of them having mild, 23.6 % moderate and 13.4 % severe levels of anxiety while 27.6% did not manifest anxiety.
Factors contributed to the level of anxiety include having a family member diagnosed with COVID-19, a family member died with COVID-19 and getting in direct contact with people infected/ suspected to have COVID-19.
Conclusions and implications for practice: The high level of exposure to contamination of Corona virus represent risk factor of nurse's fear and anxiety through their contact with patients, friends, relatives and family members. Psycho-social support programs as setting channels of one-to-one online or phone counseling for nurses may be effective to alleviate negative psychological effects and to enhance the mental health of nurses.
Comparison of intra− and postoperative variables between laparoscopic and open ovariectomy in rabbits (Oryctolagus cuniculus)
Authors: Kabakchiev Claudia , Singh Ameet , Dobson Samantha , Beaufrère Hugues 
Published: February 2021

Abstract

OBJECTIVE
To compare intraoperative and short-term postoperative variables pertaining to laparoscopic ovariectomy (LapOVE) and open ovariectomy (OVE) in rabbits (Oryctolagus cuniculus).

ANIMALS
Twelve 4− to 5-month-old female New Zealand White rabbits.

PROCEDURES
Rabbits were randomly assigned to undergo LapOVE (n = 6) or OVE (6), with a vessel-sealing device used to seal and transect the ovarian pedicles. Laparoscopic ovariectomy was performed with a 3-port approach. Variables were measured during surgery (surgery and anesthesia times and incision lengths) and for up to 7 days after surgery (food consumption, feces production, body weight, vital parameters, blood glucose and cortisol concentrations, abdominal palpation findings, facial grimace scale scores, and ethograms).

RESULTS
Mean surgery (43.2 vs 21.7 minutes) and anesthesia (76.2 vs 48.8 minutes) times were longer and mean incision length was shorter (24.0 vs 41.5 mm) for LapOVE versus OVE. No significant differences in postoperative variables were identified between groups. During LapOVE, small intestinal perforation occurred in 1 rabbit, which was then euthanized. Postoperative complications for the remaining rabbits included superficial incisional dehiscence (LapOVE, 1/5; OVE, 2/6), subcutaneous emphysema (LapOVE, 1/5; OVE, 0/6), and seroma formation (LapOVE, 1/5; OVE, 0/6).

CONCLUSIONS AND CLINICAL RELEVANCE
Surgery time for LapOVE was twice that of OVE, and LapOVE resulted in unique complications in rabbits. No evidence of a reduction in pain or faster return to baseline physiologic status was found for LapOVE. Further evaluation of LapOVE in rabbits is warranted, with modification to techniques used in this study or a larger sample size.
Zmiany w funkcjonowaniu rosyjskich parków naukowo-technologicznych
Authors: Grzyb Urszula 
Published: February 2021

Science and technology was thought to be one of the main assets of the Russian Federation, the basis for an economic recovery once it was no longer submitted to central planning. It was expected that this wealth of knowledge bequeathed from the Soviet Union would give rise to a boom in the creation of innovation companies and that foreign investment would flow in large amounts into the science sector, but both these expectations did not materialise.In Russia the first science park (science parks created by universities are called by the Russian name technoparks) was established in Tomsk in 1990 by higher education, scientific institutions and industrial enterprises jointly. Federal programmes provide support to the existing technoparks, but this support is rather meagre. Due to the industrial crisis and to the severe cutbacks in federal financing, the scientific institutions, more than 70% of which were in 1990 still connected with the military industrial complex, are nowadays experiencing a serious crisis. The number of scientific workers decreased more than twofold between 1989 and 1994 and continues to fall. Nowadays the innovation centres have a more commercial profile and, therefore, are more selective in the choice of the tenants as they have to become self-sufficient and repay the debts arising from re-construction of their premises.
Zróżnicowanie przestrzenne siły ekonomicznej wiodących przedsiębiorstw w regionie świętokrzyskim
Authors: Brambert Patryk 
Published: February 2021

The economic performance of Świętokrzyskie Voivodeship is not one of the best in the country. The level of its development is visibly lower than in the majority of provinces. However, this situation is improving, especially due to development-oriented activities of the largest regional companies. The present study shows the spatial diversity of leading enterprises’ economic power in the Świętokrzyskie Region. The market power of the enterprises which were selected from among 120 of the leading entities was determined on the basis of the following factors: income value, number of employees and the number of capital and personal relationships. The ownership and generic structures were also taken into consideration
Przemiany w geografii przemysłu
Authors: Stryjakiewicz Tadeusz 
Published: February 2021

The article has a ‘celebratory’ character connected with two jubilees:– the 25th anniversary of the Conference on Industrial Geography, organised by the Institute of Geography, Cracow Pedagogical University, in collaboration with the Industrial Geography Committee of the Polish Geographical Society; and – the 80th birthday of Professor Stanisław Misztal, Honorary President of the Industrial Geography Committee of the Polish Geographical Society.This is a good opportunity to analyse and discuss the changes which have taken place in industrial geography over this period. The discussion, presented in the first section, embraces the following issues:1. Change in the definition of the substantive scope of industrial geography;2. Methodological trends and research directions;3. A new look at the location of economic activity;4. The place of industry in on-going spatial processes.The next section of the article addresses the question of how the changes are reflected in the 25-years’ history of the Cracow Conference. The last section presents evaluation of the current state of the Polish industrial geography, including its strengths and weaknesses.
El problema de la relación entre derecho y moral
Authors: López Fuentes José Luis 
Published: February 2021

RESUMEN: En el presente trabajo, con base en las teorías iusnaturalistas y del positivismo jurídico, se busca ofrecer un breve acercamiento al desarrollo que han tenido a través del tiempo las tesis más importantes en torno al problema de la relación entre derecho y moral, hasta llegar a lo que actualmente es denominado antipositivismo jurídico, pues el objetivo de este documento es presentar un análisis y exposición de las aportaciones de esta corriente de pensamiento a la teoría jurídica contemporánea, para lo cual, se analizan las propuestas de Ronald Dworkin y Robert Alexy, en especial de la tesis de los principios, y su relevancia en la interpretación y aplicación de la ley.ABSTRACT: In this work, based on natural law theories and legal positivism, I seek to offer a brief approach to the development that the most important theses have had throughout time regarding the problem of the relationship between law and morality, arriving at what we now call legal anti-positivism, the objective of this document is to present an analysis and exposition of the contributions of this current of thought to contemporary legal theory, for which the proposals of Ronald Dworkin and Robert Alexy are analyzed, specially the thesis of the principles, and its relevance in the interpretation and application of the law.Keywords: Natural law theories, legal positivism, legal antipositivism, moral, thesis of principles.
Epidemiologia do escorpionismo na faixa etária pediátrica no estado de Minas Gerais
Authors: De Lima Caio Augusto , Alves Caroline Coutinho Horácio , Mendonça Kaio Saramago , Pires Priscilla Larissa Silva , Medeiros Nathalia Amado da Silva , Júnior Elias Rodrigues de Almeida , Carvalho Mariana , Calegari Tatiany , De Oliveira Stefan Vilges 
Published: February 2021

Objetivo: Descrever o perfil epidemiológico do escorpionismo em crianças até 14 anos no estado de Minas Gerais, Brasil. Métodos: Estudo epidemiológico, transversal, descritivo que analisou os acidentes produzidos por escorpiões em crianças, ocorridos no estado de Minas Gerais, notificados no período de janeiro de 2007 a dezembro de 2017. Resultados: Foram registrados casos de escorpionismo em 699 municípios de Minas Gerais. Os acidentes aconteceram com maior frequência na faixa etária de 10 a 14 anos, com 13.430 casos (37,63%). No grupo de um a quatro anos ocorreram 8.236 casos (23,07%) e no de cinco a nove anos 11.446 casos (32,07%). As regiões corporais mais acometidas por picadas foram o pé com 8.425 (23,60%) casos, dedo da mão com 7.244 (20,30%), mão com 5.326 (14,92%) e dedo do pé com 3.512 (9,84%). Conclusão: No período de dez anos o perfil epidemiológico foi de crianças pardas do sexo masculino, na faixa etária de 10 a 14 anos de idade, que habitam a região urbana, com evolução para cura e sobrevida. As regiões anatômicas mais acometidas foram os dedos das mãos e os pés. As manifestações clínicas foram predominantemente de leve intensidade, sendo primordial que ocorra a busca imediata por atendimento e tratamento.
A study of serum cortisol levels in patients with lichen planus
Authors: Subhash Swaroopa , Bindu R. S. , Nair Pradeep S. , George Anuja Elizabeth 
Published: February 2021

Objectives:
Primary objective was to compare between the serum cortisol levels in patients with lichen planus (LP) and normal subjects. The secondary objective was to compare between the serum cortisol levels of LP patients with and without oral lesions.

Materials and Methods:
This is a cross-sectional analytical study comparing the serum cortisol levels in patients with LP with that of age- and gender-matched normal subjects who attended a tertiary referral centre.

Results:
There were a total of 52 patients with LP in this study. The mean age was 48.1 ± 12.6 years. Male/female ratio was 1:1.9. Fifteen (28.8%) patients gave a history of recent stress in the 1 month before the onset of illness. Classical LP (34, 65.4%) was the most common type. Oral cavity was involved in 24 patients (46.2%). The mean serum cortisol level of patients with LP was higher than the same noted in age- and gender-matched normal subjects and this was statistically significant (P < 0.001). Statistically significant difference (P = 0.02) was noted between the serum cortisol levels of patients with different types of LP. No significant difference in the cortisol levels was observed between LP patients with and without oral lesions.

Limitations:
The main limitation of the study was the small sample size.

Conclusion:
This study showed a significant increase in serum cortisol levels in patients with LP when compared to normal subjects, while no significant difference was noted in cortisol levels between LP patients with and without oral lesions.