bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kikuchi‐Fujimoto disease: investigating comprehensive clinicopathological features and risk factors for recurrence
Authors: Nishimura Midori Filiz , Sakao Chikako , Kurokawa Yuka , Nishimura Yoshito , Nishikori Asami , Yamamoto Hidetaka , Sato Yasuharu 
Published: February 2025

AimsKikuchi‐Fujimoto disease (KFD) is a rare disease that typically manifests with fever and cervical lymphadenopathy. Little is known about the risk factors associated with recurrence and their correlation with clinicopathologic features.Methods and ResultsWe analysed 112 patients with KFD, predominantly female (61/112, 54.5%), with an average age of 29.4 years. The incidence was higher in males up to the age of 20 and higher in females from their 30s onwards. Of the 70 patients with follow‐up data, 23% experienced recurrence. Recurrence was associated with lower C4 levels (P = 0.038) and higher antinuclear antibody (ANA) rates (P = 0.007) compared to transient disease. The mean duration of symptoms was 71.5 days. Lymph node histology in 98 cases (excluding 14 needle biopsy specimens) was classified into three patterns: proliferative (n = 75, 77%), necrotizing (n = 22, 22%), and xanthomatous (n = 1, 1%). The necrotizing pattern associated with significantly enlarged lymph nodes (P = 0.047) and a longer symptom duration (P = 0.009) than the proliferating pattern. The number of CD4‐positive lymphocytes was significantly lower in the necrotizing type than in the proliferative type (P < 0.001).ConclusionThese results indicated that low C4 levels and positive ANA were associated with KFD recurrence. Although the aetiology of KFD remains elusive, given that some cases develop autoimmune disease, the results suggest that patients with recurrent KFD represent an intermediate status between those with transient KFD and those with overt autoimmune disease. The comprehensive clinicopathological findings of this study may be useful for elucidating its pathogenesis and predicting the clinical course.
Maternal sleep disturbance during pregnancy and child intelligence quotient: A metabolome‐wide association study in the Shanghai Birth Cohort
Authors: Huang Yun , Luo Fei , Wang Guanghai , Zhang Ting , Zhang Lin , Fan Lichun , Zhang Jun 
Published: February 2025

BackgroundThe impact of maternal sleep disturbances during pregnancy on long‐term neurodevelopment and the role of metabolites in this process are not well understood. In a prospective cohort study, we aimed to investigate the associations between maternal sleep disturbances during each trimester and child intelligence quotient (IQ) at the age of 4 years and to identify metabolites that might mediate these relationships.MethodsThis study included 1,870 mother–child pairs from the Shanghai Birth Cohort (SBC). Maternal sleep quality was assessed using the Pittsburgh sleep quality index (PSQI) questionnaire in the first and second trimesters, and a simplified version of the PSQI was used in the third trimester. Child IQ was evaluated at age 4 using the Wechsler Primary and Preschool Scale of Intelligence‐Fourth Edition (WPPSI‐IV). We conducted untargeted analyses of maternal serum metabolomics in the first trimester in 1,461 subjects. We employed multiple linear regression models to examine the associations between maternal sleep disturbances during each trimester and child IQ. Additionally, we utilized longitudinal latent class analysis (LLCA) to identify patterns of sleep quality changes throughout the three trimesters and employed multiple linear regression models to investigate how these sleep patterns across the entire pregnancy were associated with child IQ. We applied a ‘meet‐in‐the‐middle’ approach to identify potential metabolites linking maternal sleep disturbances during early pregnancy with child IQ.ResultsLonger sleep latency was associated with lower child Full‐Scale IQ (FSIQ) and verbal comprehension index (VCI) for the first trimester, while lower child fluid reasoning index (FRI) for the second trimester. Longer sleep latency throughout the pregnancy was associated with decreased FSIQ (β = −4.68; 95% CI: −8.32, −1.03), VCI (β = −6.38; 95% CI: −10.39, −2.37), and FRI (β = −4.29; 95% CI: −7.96, −0.63). We found that inositol, indoleacrylic acid, and 4‐hydroxyquinoline emerged as potential biomarkers that play an intermediary role in the association between maternal sleep disturbances and child IQ.ConclusionsSleep disturbance during pregnancy may be a risk factor for compromised IQ in preschool‐aged offspring. Alterations in inositol and tryptophan metabolism might be the mediator for the link between maternal sleep disturbances and child IQ.
Future disposal surge: A new quantification approach for predicting waste from external thermal insulation composite systems in Germany
Authors: Bischof Rafael , Volk Rebekka , Schultmann Frank 
Published: February 2025

AbstractThis study quantifies external thermal insulation composite systems (ETICS), in particular expanded polystyrene (EPS) as the insulation layer, installed in Germany between 1969 and 2022. Employing a bottom‐up approach, it conducts mass quantification, localization at the NUTS‐3 level, determination of installation years, and prediction of future waste for both ETICS in general and EPS ETICS specifically. The methodology involves categorizing the German residential and non‐residential building stock into further subcategories and construction age classes to determine their respective insulation parameters such as insulation rate and thickness providing insights into the distribution of ETICS quantities across building categories and types, construction years, and administrative districts. Additionally, waste stream predictions are carried out through surveys on ETICS lifetimes and single‐house‐level sampling of probabilistic lifetimes. The findings project a quadrupling of annual EPS waste generation from ETICS by 2050 compared to today, with 79% attributed to residential and 21% to non‐residential buildings, predominantly in urban areas. The results of the ETICS waste prediction indicate that currently established disposal routes are unfit to handle future waste generation, underlining the importance of alternative recycling paths for ETICS and improved waste disposal policies.
Frontiers in radiopharmaceuticals for neuroendocrine tumors
Authors: Puranik Ameya D. , Dev Indraja D. , Prasad Vikas 
Published: February 2025

AbstractNeuroendocrine tumors encompass a wide range of tumors which originate from neural crest cells. These tumors were thought to be rare tumors, however, with the advent of advanced diagnostic techniques along with better understanding of the clinical presentation and histology of these tumors, the incidence of these tumors is exponentially rising. As the incidence and detection rate of NENs increased, the concept of ‘heterogeneity’ came into picture, which in turn led to dual‐tracer imaging with addition of FDG PET/CT. Despite an imaging‐based decision‐making approach for NENs, there is still a significant subset of patients where the imaging‐based biomarkers fall short in disease assessment, prognostication and improving outcomes. Alternate pathways as well as better peptide vectors for targeting the somatostatin receptor need to be studied. In this article, we address the existing as well as emerging trends in radiopharmaceuticals used for NENs, which are likely to impact not just the diagnostic algorithms in future, but also management strategies.
The Effect of Communication in Emergency Department Isolation Rooms Using Smart Glasses: A Mixed‐Methods Study
Authors: Park Soyoung , Lee Hyeongsuk 
Published: February 2025

ABSTRACTAimTo assess the effectiveness of using smart glasses to facilitate communication among nurses inside and outside the emergency department.DesignComplementary mixed‐methods study with a one‐group pretest‐posttest design.MethodsThirty emergency nurses participated in surveys on demographics, digital literacy, and communication clarity before and after using smart glasses. Qualitative interviews explored user experiences.ResultsSmart glasses improved communication clarity. No significant correlation was found between demographics or clinical experience and communication clarity. Qualitative analysis identified five facilitating factors—reduced nursing workload, enhanced patient care, improved efficiency, reliable support, and professional feel—and five barriers—user interface issues, surveillance burden, communication errors, technology‐integration limitations, and ethical/patient privacy concerns.ConclusionSmart glasses improved communication in emergency isolation rooms, potentially enhancing patient safety and reducing treatment delays. Addressing usability and ethical concerns is key for successful integration.Implications for the Profession and/or Patient CareSmart glasses offer significant potential to enhance communication. To maximise their benefits, it is crucial to address challenges such as the added stress on novice nurses, potential increases in workload, and ethical concerns regarding patient privacy. Providing comprehensive training and refining the technology will help to reduce user burden and ensure robust data security, ultimately improving patient care and supporting nursing staff in high‐stress environments.ImpactSmart glasses can improve communication among emergency nurses, especially in isolation rooms, by reducing treatment delays and enhancing collaboration, thus improving patient safety.Reporting MethodTREND (Nonrandomised evaluations of behavioural and public health interventions).Patient or Public ContributionEmergency nurses' feedback was integral to evaluating the usability and effectiveness of smart glasses.
Gender and housework in the post‐retirement context: Longitudinal evidence from the U.S.
Authors: Hwang In Jeong , Svec Joseph , Lee Jeong Eun 
Published: February 2025

AbstractObjectiveThis study assesses the role of retirement as an equalizer for couple's housework production in tandem with changing demands for different types of housework after retirement.BackgroundRetirement has received attention as an equalizer for household gender inequality. Among various changes brought by retirement, changing demands for housework can have different implications depending on chore types due to gender task segregation.MethodsUsing the Health and Retirement Study from 976 couples (N = 3,404) and fixed effects models, we predict the difference between husbands’ and wives’ housework time among different‐gender married dual‐earner couples as a function of retirement arrangements, time spent on feminine‐ and masculine‐typed chores, controlling for sociodemographic characteristics and time.ResultsCouple's retirement arrangements were generally not independently associated with housework gender inequality, but they moderated the effects of demands for gender‐normative tasks. Consistent with the prediction that feminine‐typed chores fall upon wives and masculine‐typed chores on husbands, couples were more egalitarian when there was less feminine‐typed chore to distribute. More masculine‐typed chore contributed to gender equality but only under limited circumstances.ConclusionWe found some evidence of gender task segregation but limited support for retirement as an equalizer. Even though husbands’ retirement brings an opportunity to improve housework gender equality, the success depends on the level of demands for gender‐normative tasks.ImplicationsThis study highlights how gender ideological scripts can frame relational expectations and persist despite shifts in economic contributions to the household.
Study the past if you would define the future: Historical methods in medical education scholarship
Authors: Ellaway Rachel , MacLeod Anna , van Schalkwyk Susan , Cleland Jennifer 
Published: February 2025

AbstractIntroductionA study was conducted to describe the state of historical scholarship in medical education including its strengths and opportunities as well as its shortcomings, lacunae, inattentions, and failings. The study took a particular focus on historical methods and methodologies and whether they have been applied appropriately and with rigour. The study serves as a descriptive scan of historical scholarship, as a guide to the use of historical methods for authors, editors and reviewers, and as a possible course correction for improved standards in approaching and reporting on the past in medical education scholarship.MethodA meta‐study review was conducted to explore the current state of historical scholarship in medical education, to understand the state of the art, and to improve methodological, analytical and reporting rigour. Structured searches were conducted, returns were filtered for inclusion, and 85 articles and chapters were critically analysed.ResultsAlthough there were some exemplary articles identified, the majority reflected many deficits in scholarly practice. Seven broad issues in historical scholarship in medical education were identified that all spoke to the absence of key dimensions of sound scholarship namely: an explicit methodology, explicit engagement with theory, attention to replicability, reflective critique, sources of evidence, a balanced argument, and attention to positionality.DiscussionThe issue at hand is not simply about aligning historical scholarship with the standards of social science (such as engaging with methodology, theory and reflexivity), although the authors argue that scholars should do so where appropriate. Rather, it is about the implications these findings have for future work in the field of medical education in studying its many intertwined histories. To that end, there is a discursive space for historical scholarship in medical education that needs further exploration and development to bring together the best of scholarship from the traditions of medical education and history.
The Prevalence of Onchomycosis in Psoriasis Patients: A Systematic Review and Meta‐Analysis
Authors: Liu Mengying , Kang Yuying , Zhang Ruijun 
Published: February 2025

ABSTRACTIntroductionOnychomycosis, a common nail disease characterised by thickened, discoloured and brittle nails, has been observed to have varying prevalence rates in psoriasis patients compared to the general population. Psoriasis is a chronic autoimmune condition affecting approximately 2%–3% of the global population, with nail involvement impacting up to 79% of these patients. The clinical features of onychomycosis and nail psoriasis often overlap, complicating accurate diagnosis. This systematic review and meta‐analysis aims to evaluate whether the prevalence of onychomycosis differs between psoriasis patients and non‐psoriasis individuals, thereby providing evidence‐based insights for clinical practice.MethodsThe research question and keywords were developed following the Population, Intervention, Comparator, and Outcome (PICO) framework. As of October 26, 2024, records in English or Chinese were obtained from PubMed, Embase, Cochrane Library, CNKI, CBM and Web of Science, using the keywords “onychomycosis,” “psoriasis,” etc. Furthermore, the meta‐analysis was carried out with STATA.ResultsA total of 967 records were identified, with 13 studies comprising 2751 psoriasis patients and 10,967 non‐psoriasis individuals included in the final analysis. The meta‐analysis revealed that psoriasis patients had a significantly higher prevalence of onychomycosis, 1.68 times greater than those without psoriasis (95% CI: 1.21–2.33). Subgroup analysis showed that among clinically unsuspected patients, the risk of onychomycosis in those with psoriasis was 1.78 times higher (95% CI: 1.33–2.38) than in non‐psoriasis individuals. The majority of the studies included were of moderate to low bias.ConclusionThe prevalence of onychomycosis is significantly higher in psoriasis patients compared to those without. However, limitations in research methods, variability in study populations, and small sample sizes in some studies suggest that further investigation is necessary. Future research should employ standardised methodologies, larger sample sizes, and long‐term follow‐up to enhance the accuracy and reliability of findings. Based on the results of this review and meta‐analysis, it is crucial to rule out onychomycosis‐related nail lesions before diagnosing psoriasis, especially prior to initiating immunosuppressive treatments such as steroids, methotrexate, or biologics, as these may exacerbate fungal infections.Protocol RegistrationPROSPERO—CRD42023399195.
MitoQ Preserves Epigenetic Modifications and Quality Parameters of Rooster Sperm During Cryopreservation Process
Authors: Alipour‐Jenaghard Parisa , Daghigh‐Kia Hossein , Masoudi Reza , Hatefi Ali 
Published: February 2025

ABSTRACTCryopreservation in rooster semen is a helpful procedure to spread qualified semen samples for reproductive goals. Nevertheless, some post‐thawed qualified semen samples showed a considerably poor fertility rate that might be related to epigenetic modifications during the cryopreservation process. This study aims to investigate the effect of the cryopreservation process in the presence of MitoQ as a mitochondrial‐targeted antioxidant on epigenetic changes and other quality parameters (motility, morphology, mitochondrial activity, acrosome integrity, lipid peroxidation, DNA fragmentation, apoptosis status, and ROS concentration) of rooster sperm. The collected semen samples were divided into four groups of fresh samples and three groups that were supplemented by MitoQ 0, 10, and 100 nM and cryopreserved. The cryopreservation process reduced (p ≤ 0.05) DNA methylation, H3K9 acetylation, H3K4 methylation, motility parameters, membrane integrity, mitochondrial activity, acrosome integrity, viability, and increased (p ≤ 0.05) lipid peroxidation, DNA fragmentation, ROS concentration, and apoptotic‐like changes compared to the fresh semen group. However, in frozen sperm groups, MitoQ 10 and 100 nM resulted in significant improvements (p ≤ 0.05) in the epigenetic modifications and other mentioned quality parameters compared to the control group (MitoQ 0). Generally, although the cryopreservation process reduced semen quality, using MitoQ could be useful in cryopreserved rooster semen quality.
Integrated testing strategies for cost‐sensitive time‐efficient hazard classification of new chemicals: The case of skin sensitization
Authors: Raseta Marko , Pitchford Jon , Cussens James , Doe John 
Published: February 2025

AbstractWe offer an alternative approach to toxicological risk assessment of new chemicals. We combine Operations Research techniques with those from Machine Learning to tackle the decision‐making process. More specifically, we use Markov decision processes and Bayesian networks to derive the optimal cost‐sensitive time‐efficient Integrated Testing Strategies for chemical hazard classification under minimal expected cost in a mathematically rigorous fashion. We develop Bayesian networks which outperform state‐of‐the‐art mechanistic causal models previously reported. More specifically, these models exhibit accuracy of 90% and sensitivity and specificity of 93% and 84%, respectively. Moreover, the inferred Bayesian networks are of considerably simpler structure as they comprise only the permeation coefficient, octanol/water coefficient, and TIMES software compared to their counterparts already in print, which comprise 15 descriptors. We use these simplified causal models to study the effect of varying misclassification costs on the nature of the optimal policy by means of sensitivity analysis. We note such analysis was previously computationally infeasible due to the fact that the variables which comprised the mechanistic model were categorical assuming a large number of possible values. We find that a variety of optimal policies can emerge subject to different misclassification costs assumed. Theoretical modeling framework developed is illustrated on the concrete example of hazard classification of skin allergens of previously unknown toxicological characteristics via integrating data obtained from in silico assays alone thus contributing to the literature of toxicological decision making based on nonanimal tests.
Hydrocarbon Revenues, the Non‐Hydrocarbon Tax Offset, and the Government Policy Mix
Authors: Elbahnasawy Nasr G. , Sweidan Osama D. , Razavi Rouzbeh 
Published: February 2025

ABSTRACTThe paper investigates the influence of the government policy‐mix choices of fiscal, exchange rate, and monetary policies, as reflected in reserve money changes, on government tax effort and the non‐hydrocarbon tax offset. We find a positive association between changes in reserve money and the non‐hydrocarbon tax offset. Hydrocarbon‐dependent countries that rely more on seigniorage or allocate a larger share of hydrocarbon revenues to the current budget will exhibit higher reserve money growth and reduced tax effort. The combined effect of hydrocarbon revenues and reserve money growth indicates that tax effort is significantly lower than previously suggested in the literature, with a tax offset of approximately 60%, implying higher adjustment costs and a greater need to develop tax capacity in hydrocarbon‐dependent countries. Furthermore, reserve money growth conditions the magnitude of the non‐hydrocarbon tax offset arising from hydrocarbon revenues.
Economies of Scale for Household Wealth: An Analysis of Equivalence Scales
Authors: Rapp Severin 
Published: February 2025

ABSTRACTMeasures of private wealth often refer to households or tax‐units, but how does household wealth relate to individual welfare? Analogous to household economies of scale for consumption, this paper offers a methodology and empirical results to account for household wealth scale effects. These scale effects vary depending on the purpose of savings: funding consumption versus holding wealth for motives such as status (wealth‐in‐utility savings). Using the German Socio‐Economic Panel's stated preference data, I estimate that economies of scale for wealth‐in‐utility savings are high. In addition, the paper offers an empirical application with regard to inequality measurement. As high wealth‐in‐utility economies of scale dominate among the wealthy, estimates of inequality tend to increase. Accounting for scale effects has moderate effects on the Gini index and top wealth shares in Germany, but reduces the wealth share of the bottom 50% of the distribution by up to half.