bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Pengelolaan Barang Pada Optik Mandiri Condet Jakarta
Authors: Apriyanto Apriyanto 
Published: September 2021

Saat ini teknologi informasi melaju dengan cepatnya seiring dengan perkembangan komputer yang menjadi alat untuk memprosesnya. Software dan hardware penunjang kemajuan teknologi informasi sangat memegang peran penting didalam pengelolaan sebuah sistem disamping peran manusia sebagai operatornya. Optik Mandiri Condet di Jakarta membutukan sekali adanya suatu sistem informasi pengelolaan barang yang akan memudahkan dalam hal pelayanan kepada setiap pelanggan. Sistem yang ada pada Optik Mandiri Condet ini masih dilakukan secara manual, mulai dari pencatatan customer yang membeli barang, sampai penyimpanan data-data lainnya yang berhubungan dengan proses penjualan hingga sampai pembuatan laporan, sehingga memungkinkan pada saat proses berlangsung terjadi kesalahan dalam pencatatan, kurang akuratnya laporan yang dibuat dan keterlambatan dalam pencarian data-data yang diperlukan. Untuk itu dibuatlah sebuah sistem pengelolaan barang dengan tujuan untuk pelayanan dalam hal penjualan dan pengelolaan barang yang ada pada Optik Mandiri Condet Jakarta. Metode yang digunakan pada perancangan sistem ini menggunakan model waterfall, perancangan database menggunakan Entity Relationship Diagram dan logical Recors Structure. Digunakan juga struktur navigasi untuk alur jalannya proses program. Bahasa pemrograman menggunakan PHP sebagai program web, dan MySQL sebagai aplikasi database. Perancangan sistem informasi ini merupakan solusi terbaik untuk memecahkan permasalahan yang ada pada perusahaan ini terutama permasalahan dalam pelayanan dan pengelolaan barang dengan memanfaatkan kemajuan teknologi informasi dan komunikasi
Analisis Dan Perancangan Sistem Informasi Website Penjualan Kosmetik Beautycare
Authors: Salim Rin Rin Meilani 
Published: September 2021

Website menjadi kebutuhan bagi sebuah organisasi, instansi, perusahaan komersil, dan lain sebagainya. Kebutuhan tersebut biasanya tidak hanya untuk promosi, namun juga kegiatan bisnis. E-commerce biasanya berkaitan dengan penjualan. Beautycare merupakan website yang bergerak dalam bidang penjualan kosmetik sehingga sangat membutuhkan media pemasaran yang lebih luas sekaligus untuk memberikan pelayanan yang lebih baik kepada pelanggan. Untuk itu dalam penulisan tugas akhir ini, penulis membuat website kosmetik yang menyediakan layanan konsultasi dengan dokter kecantikan. Dalam perancangan website penulis menggunakan metode pengembangan SDLC. Untuk desain website yang digunakan adalah Adobe XD cc dan database yang digunakan adalah MySql. Website dinilai efektif sebagai media alternatif untuk pemasaran dan sekaligus memberikan layanan terbaru kepada pelanggan, selain itu dengan adanya sistem informasi penjualan dan pemesanan secara online ini, diharapkan dapat meningkatkan pelayanan kepada konsumen. Hal ini dilihat dari kebutuhan pelanggan terhadap informasi tentang kecantikan yang semakin lama semakin meningkat, sehingga dibutuhkan sebuah sistem yang dapat melayani kebutuhan pelanggan tersebut.
Disaster Recovery Centre Menggunakan Hot Standby System pada BPR Universal
Authors: Rosano Andi 
Published: September 2021

Kehidupan manusia pada saat ini tak bisa dilepaskan dari perkembangan teknologi informasi (TI), dimana manusia sudah sangat tergantung kepadanya. Bukan hanya individu manusia namun juga perusahaan, instansi pemerintah, institusi pendidikan pun juga sangat tergantung pada teknologi informasi. Pemanfaatan TI untuk kegiatan usaha keuangan, khususnya perbankan, sudah merupakan keharusan, baik operasional maupun layanan masyarakat dan promosi. Kegiatan bisnis BPR Universal yang mengandalkan TI sebagai sarana untuk meningkatan keuntungan dan kinerja tentulah menuntut tingkat ketersediaan sistem yang tinggi. Sistem dengan availabilitas tinggi sangat penting dimiliki, oleh karena itu diperlukan sebuah perencanaan untuk mengatasi masalah jika terjadi gangguan pada infrastruktur TI, server, aplikasi dan data. Untuk mengatasi masalah yang timbul setiap saat dan akan menimbulkan down time yang lama pada sistem data centre, maka diperlukan sebuah disaster recovery centre. Banyak cara atau metode yang dapat digunakan, namun pada tulisan ini akan dibahas penggunaan metode Hot standby untuk menanggulangi kegagalan sistem akibat bencana. Metode Sistem hot standby mengaktifkan semua infrastruktur TI data centre utama dan data centre cadangan, sehingga ketika terjadi masalah secara otomatis data centre cadangan akan langsung aktif untuk mengganti peran dari data centre utama dalam operasional.
Rancang Bangun Aplikasi Belajar Mengajar Pada Bimbel Bahasa Inggris berbasis web
Authors: Hidayat Rachmat , Zahra Zahra , Asmadi Iwan 
Published: September 2021

Internet sudah banyak digunakan dalam berbagai bidang, seperti informasi, telekomunikasi, perdagangan, hingga pendidikan, sehingga memudahkan suatu perusahaan atau institusi memberikan informasi yang sangat berguna bagi masyarakat terkadang masih ada juga instansi yang belum menggunakan aplikasi berbasi web untuk kegiatan usahanya, salah satunya adalah lembaga pendidikan bimbingan belajar bahasa inggris yang berada di kota tangerang dengan jumlah siswa dan pengajar yang banyak, masih menerapkan sistem penjadwalan secara konvensional, dimana pihak admin akan menghubungi siswa dan pengajar melalui telepon jika ada kelas pengajaran, kendala lainya pihak admin lupa memberitahukan ke siswa dan pengajar jika ada jadwal, jadwal yang diberikan tidak sesuai dan bentrok dengan kelas lain, siswa atau pengajar tidak dapat menghubungi pihak admin untuk mendapatkan informasi jadwal. Dengan memafaatkan teknologi informasi permasalahan tersebut dapat dipermudah dengan dibuatkan racngan bangun aplikasi belajar mengajar berbasis web yang dikembangkan dengan metode waterfall. Metode pengembangan ini meliputi analisis kebutuhan, perancangan, implementasi, dan pengujian. Pada tahap analisis kebutuhan dilakukan pemodelan proses bisnis to-be yang dibuat berdasarkan hasil wawancara dengan stakeholder dan analisis permasalahan. Hasil perancangan aplikasi menghasilkan aplikasi yang dapat melakukan manajemen pengelolahan penjadwal data pengajar, data pelajararan dan data siswa, yang akan tersimpan didalam database.
Ultrasound-Guided Radiofrequency Ablation Versus Surgical Resection for the Treatment of T1bN0M0 Papillary Thyroid Carcinoma in Different Age Groups
Authors: He Hongying , Wu Rilige , Zhao Jiahang , Song Qing , Zhang Yan , Luo Yukun 
Published: September 2021

PurposeWe aimed to compare the efficacy and safety of radiofrequency ablation (RFA) to that of surgical resection (SR) in patients with T1bN0M0 papillary thyroid carcinoma (PTC) in different age groups.MethodsTotally, 204 patients with an isolated, solitary, intrathyroidal T1bN0M0 PTC, who underwent either RFA (n=94) or SR (n=110) between April 2014 and December 2019, were retrospectively enrolled and were divided into two subgroups according to age (&lt;45 years, ≧45 years). Patients with pathologically aggressive or advanced lesions were excluded from the study. Tumor progression and procedural complications were the primary and secondary endpoints, respectively. Tumor recurrence in situ, newly discovered tumors, lymph node involvement, or distant metastases indicated tumor progression. Complications included pain, fever, voice change, choking, numbness in the limbs, and cardiac events. Incidence rates of all endpoint events were compared between different age subgroups.ResultsThere were no significant differences in age, sex, and tumor size between the treatment groups. While the RFA group incurred less cost and experienced significantly shorter operative duration than the SR group, no significant differences were observed in incidences of both tumor progression and complications. Further, subgroup analysis of patients &lt;45 years versus those ≧45 years showed no significant differences in the incidence of tumor progression and complications within or between different treatment groups. Older patients in the SR group incurred higher hospital costs than younger counterparts, but this difference was not observed in the RFA group.ConclusionsOur results indicated that RFA had a similar prognosis as that of SR but was associated with lower overall cost in both young (&lt;45 years) and middle-aged patients (≧45 years) with T1bN0M0 PTC. Therefore, RFA may be an effective and safe alternative to surgery for the treatment of patients with T1bN0M0 PTC.
Landscape of Immune Microenvironment Under Immune Cell Infiltration Pattern in Breast Cancer
Authors: Xu Qianhui , Chen Shaohuai , Hu Yuanbo , Huang Wen 
Published: September 2021

BackgroundIncreasing evdence supports the suggestion that the immune cell infiltration (ICI) patterns play a pivotal role in tumor progression in breast cancer (BRCA). Nonetheless, there has been no comprehensive analysis of the ICI patterns effects on the clinical outcomes and immunotherapy.MethodsMultiomic data for BRCA samples were downloaded from TCGA. ESTIMATE algorithm, ssGSEA method, and CIBERSORT analysis were used to uncover the landscape of the tumor immune microenvironment (TIME). BRCA subtypes based on the ICI pattern were identified by consensus clustering and principal-component analysis was performed to obtain the ICI scores to quantify the ICI patterns in individual tumors. Their prognostic value was validated by the Kaplan-Meier survival curves. Gene set enrichment analysis (GSEA) was applied for functional annotation. Immunophenoscore (IPS) was employed to explore the immunotherapeutic role of the ICI scores. Finally, the mutation data was analyzed by using the “maftools” R package.ResultsThree different immune infiltration patterns with a distinct prognosis and biological signature were recognized among 1,198 BRCA samples. The characteristics of TIME under these three patterns were highly consistent with three known immune profiles: immune- excluded, immune-desert, and immune-inflamed phenotypes, respectively. The identification of the ICI patterns within individual tumors based on the ICI score, developed under the ICI-related signature genes, contributed into dissecting biological processes, clinical outcome, immune cells infiltration, immunotherapeutic effect, and genetic variation. High ICI score subtype, characterized with a suppression of immunity, suggested an immune-exhausted phenotype. Abundant effective immune cells were discovered in the low ICI score patients, which corresponded to an immune-activated phenotype and might present an immunotherapeutic advantage. Immunophenoscore was implemented as a surrogate of immunotherapeutic outcome, low-ICI scores samples obtained a significantly higher immunophenoscore. Enrichment of the JAK/STAT and VEGF signal pathways were activated in the ICI low-score subgroup. Finally, the synergistic effect between the ICI score and the tumor mutation burden (TMB) was confirmed.ConclusionThis work comprehensively elucidated that the ICI patterns served as an indispensable player in complexity and diversity of TIME. Quantitative identification of the ICI patterns in individual tumor will contribute into mapping the landscape of TIME further optimizing precision immunotherapy.
Type 2 Diabetes Mellitus and Latent Tuberculosis Infection Moderately Influence Innate Lymphoid Cell Immune Responses in Uganda
Authors: Ssekamatte Phillip , Nakibuule Marjorie , Nabatanzi Rose , Egesa Moses , Musubika Carol , Bbuye Mudarshiru , Hepworth Matthew R. , Doherty Derek G. , Cose Stephen , Biraro Irene Andia 
Published: September 2021

BackgroundType 2 diabetes mellitus (T2DM) is a major risk factor for the acquisition of latent tuberculosis (TB) infection (LTBI) and development of active tuberculosis (ATB), although the immunological basis for this susceptibility remains poorly characterised. Innate lymphoid cells (ILCs) immune responses to TB infection in T2DM comorbidity is anticipated to be reduced. We compared ILC responses (frequency and cytokine production) among adult patients with LTBI and T2DM to patients (13) with LTBI only (14), T2DM only (10) and healthy controls (11).MethodsUsing flow cytometry, ILC phenotypes were categorised based on (Lin−CD127+CD161+) markers into three types: ILC1 (Lin−CD127+CD161+CRTH2-CD117−); ILC2 (Lin−CD127+CD161+CRTH2+) and ILC3 (Lin−CD127+CD161+CRTH2−NKp44+/−CD117+). ILC responses were determined using cytokine production by measuring percentage expression of interferon-gamma (IFN-γ) for ILC1, interleukin (IL)-13 for ILC2, and IL-22 for ILC3. Glycaemic control among T2DM patients was measured using glycated haemoglobin (HbA1c) levels. Data were analysed using FlowJo version 10.7.1, and GraphPad Prism version 8.3.ResultsCompared to healthy controls, patients with LTBI and T2DM had reduced frequencies of ILC2 and ILC3 respectively (median (IQR): 0.01 (0.005-0.04) and 0.002 (IQR; 0.002-0.007) and not ILC1 (0.04 (0.02-0.09) as expected. They also had increased production of IFN-γ [median (IQR): 17.1 (5.6-24.9)], but decreased production of IL-13 [19.6 (12.3-35.1)]. We however found that patients with T2DM had lower ILC cytokine responses in general but more marked for IL-22 production (median (IQR): IFN-γ 9.3 (4.8-22.6); IL-13 22.2 (14.7-39.7); IL-22 0.7 (IQR; 0.1-2.1) p-value 0.02), which highlights the immune suppression status of T2DM. We also found that poor glycaemic control altered ILC immune responses.ConclusionThis study demonstrates that LTBI and T2DM, and T2DM were associated with slight alterations of ILC immune responses. Poor T2DM control also slightly altered these ILC immune responses. Further studies are required to assess if these responses recover after treatment of either TB or T2DM.
Statin Treatment in the Acute Phase and the Risk of Post-stroke Pneumonia: A Retrospective Cohort Study
Authors: Li Changling , Ma Mengmeng , Dong Shuju , Hong Ye , Bao Jiajia , Zhang Yang , Gao Lijie , Cui Chaohua , Guo Jian , He Li 
Published: September 2021

Background: We aimed to investigate the impact of statin treatment in the acute phase on the risk and severity of post-stroke pneumonia because of the uncertain effects of statins on post-stroke pneumonia.Methods: Consecutive cases of acute ischemic stroke (AIS) between January 2014 and February 2019 were retrospectively analyzed. Additionally, the association of statin treatment in the acute phase with the risk and severity of post-stroke pneumonia was estimated with logistic regression. We registered the present study in the Chinese Clinical Trial Registry (ChiCTR 2000032838).Results: Of the 1,258 enrolled patients, no significant difference was observed in post-stroke pneumonia risk between the two groups (with/without statin treatment in the acute phase) after propensity score matching (35.1 vs. 27.9%, p = 0.155). We did not find statin treatment in the acute phase to significantly increase the risk of post-stroke pneumonia both before and after matched analysis [odds ratio (OR) = 1.51, 95% confidence interval (CI) = 0.85–2.67, p = 0.157; OR = 1.57, 95% CI = 0.77–3.18, p = 0.213, respectively]. In the 271 patients with post-stroke pneumonia, no significant difference was found in its severity between two groups (19.6 vs. 19.4%, p = 0.964). No significant association was found between statin treatment and post-stroke pneumonia severity (OR = 0.95, 95% CI = 0.39–2.31, p = 0.918).Conclusions: There appeared to be no additional benefits of statin treatment in the acute phase for post-stroke pneumonia reduction among AIS patients.Clinical Trial Registration:http://www.chictr.org.cn, identifier: ChiCTR2000032838.
Effects of Transcutaneous Spinal Direct Current Stimulation (tsDCS) in Patients With Chronic Pain: A Clinical and Neurophysiological Study
Authors: Guidetti Matteo , Ferrucci Roberta , Vergari Maurizio , Aglieco Giada , Naci Anisa , Versace Sara , Pacheco-Barrios Kevin , Giannoni-Luza Stefano , Barbieri Sergio , Priori Alberto , Bocci Tommaso 
Published: September 2021

Background and Aims: Chronic pain is a complex clinical condition, often devastating for patients and unmanageable with pharmacological treatments. Converging evidence suggests that transcutaneous spinal Direct Current Stimulation (tsDCS) might represent a complementary therapy in managing chronic pain. In this randomized, double-blind and sham-controlled crossover study, we assessed tsDCS effects in chronic pain patients.Methods: Sixteen patients (aged 65.06 ± 16.16 years, eight women) with chronic pain of different etiology underwent sham and anodal tsDCS (anode over the tenth thoracic vertebra, cathode over the somatosensory cortical area: 2.5 mA, 20 min, 5 days for 1 week). As outcomes, we considered the Visual Analog Scale (VAS), the Neuropathic Pain Symptom Inventory (NPSI), and the components of the lower limb flexion reflex (LLFR), i.e., RIII threshold, RII latency and area, RIII latency and area, and flexion reflex (FR) total area. Assessments were conducted before (T0), immediately at the end of the treatment (T1), after 1 week (T2) and 1 month (T3).Results: Compared to sham, anodal tsDCS reduced RIII area at T2 (p = 0.0043) and T3 (p = 0.0012); similarly, FR total area was reduced at T3 (p = 0.03). Clinically, anodal tsDCS dampened VAS at T3 (p = 0.015), and NPSI scores at T1 (p = 0.0012), and T3 (p = 0.0015), whereas sham condition left them unchanged. Changes in VAS and NPSI scores linearly correlated with the reduction in LLFR areas (p = 0.0004).Conclusions: Our findings suggest that tsDCS could modulate nociceptive processing and pain perception in chronic pain syndromes.
Factors That Influence Compliance to Long-Term Remote Ischemic Conditioning Treatment in Patients With Ischemic Stroke
Authors: Zhao Jie , Fan Kaiting , Zhao Wenbo , Yao Hui , Ma Jiayue , Chang Hong 
Published: September 2021

Objectives: To investigate the treatment compliance of patients with ischemic stroke to remote ischemic conditioning (RIC) and to determine the factors that influence compliance.Methods: We conducted a retrospective study of patients with ischemic stroke who were treated with RIC. Treatment compliance was determined and analyzed in patients who had received 1 year of RIC training. Factors that influenced patient compliance were also determined using univariate and multivariate regression analyses.Results: Between March 2017 and February 2018, 91 patients were recruited into this study. The mean (±SD) age was 57.98 ± 10.76 years, and 78 (85.7%) patients were male. The baseline Kolcaba comfort scale of patients with good compliance scores were higher than those with poor compliance. The scores of the four dimensions in the scale and the total score are as follows: physiological dimensions, 15.0 (12.0,17.0) vs 17.0 (13.0,19.0); psychological dimensions, 30.0 (25.0,34.0) vs 31.0 (27.0,35.0); sociological dimensions, 20.0 (18.0,24.0) vs 21.0 (18.0,23.0); environmental dimensions, 19.0 (12.0,24.0) vs 20.0 (17.0,22.0); and total points, 82.0 (69.0,94.0) vs 91.0 (78.0,98.0). the differences between the groups were significant (p &lt; 0.05), except for the sociological dimensions. A history of hypertension, number of follow-ups, and the physiological, psychological, and environmental dimensions of the comfort scale were related to patient compliance, out of which the number of follow-ups (Adjusted OR = 2.498, 95% confidence interval (CI) 1.257–4.964) and the physiological discomfort (Adjusted OR = 1.128, 95% CI 1.029–1.236) independently influenced compliance (p &lt; 0.05).Conclusion: In patients with ischemic cerebrovascular disease who were treated with RIC, the number of follow-up visits and physiological discomfort associated with RIC treatment independently influenced patient compliance. Further studies are needed to investigate the RIC protocols and their corresponding nursing models.
Changes in Mortality Related to Traumatic Brain Injuries in the Seychelles from 1989 to 2018
Authors: Abio Anne , Bovet Pascal , Valentin Bernard , Bärnighausen Till , Shaikh Masood Ali , Posti Jussi P. , Lowery Wilson Michael 
Published: September 2021

Introduction: Traumatic Brain Injuries (TBIs) are a significant source of disability and mortality, which disproportionately affect low- and middle-income countries. The Republic of Seychelles is a country in the African region that has experienced rapid socio-economic development and one in which all deaths and the age distribution of the population have been enumerated for the past few decades. The aim of this study was to investigate TBI-related mortality changes in the Republic of Seychelles during 1989–2018.Methods: All TBI-related deaths were ascertained using the national Civil Registration and Vital Statistics System. Age- and sex-standardised mortality rates (per 100,000 person-years) were standardised to the age distribution of the World Health Organisation standard population.Results: The 30-year age-standardised TBI-related mortality rates were 22.6 (95% CI 19.9, 25.2) in males and 4.0 (95% CI 2.9, 5.1) in females. Road traffic collisions were the leading contributor to TBI-related mortality [10.0 (95% CI 8.2, 11.8) in males and 2.7 (95% CI 1.8, 3.6) in females, P &gt; 0.05]. TBI-related mortality was most frequent at age 20–39 years in males (8.0) and at age 0–19 in females (1.4). Comparing 2004–2018 vs. 1989–2003, the age-standardised mortality rates changed in males/females by −20%/−11% (all cause mortality), −24%/+39.4% (TBIs) and +1%/+34.8% (road traffic injury-related TBI).Conclusion: TBI-related mortality rates were much higher in males but decreased over time. Road traffic collisions were the single greatest contributor to TBI mortality, emphasising the importance of road safety measures.
Linking Dietary Patterns to Environmental Degradation: The Spatiotemporal Analysis of Rural Food Nitrogen Footprints in China
Authors: Xian Chao-Fan , Gong Cheng , Lu Fei , Zhang Lu , Ouyang Zhi-Yun 
Published: September 2021

Background: China has a large emerging economy that illustrates how dietary patterns can affect food-source nitrogen (N) cycling. The indicator of food nitrogen footprint (NF) reflects the amount of reactive nitrogen (Nr) emissions and impacts of these emissions on the environment. It is a result of food production and consumption to satisfy basic dietary demands of a given population. Different from urban food consumption with improved waste treatment, rural food consumption significantly affects the environment from food production to waste disposal. We therefore, performed a nationwide case study to link dietary patterns to environmental degradation based on rural food NF accounting.Methods: The N-Calculator model was adopted to reveal the spatiotemporal characteristics of food NFs per capita, and regional food NFs related to rural diets in China from 2000 to 2019. Then, food-source Nr emissions to regional environment were quantified based on food NF accounting and relevant inventory of regional Nr emissions.Results: (i) The average annual food NF per-capita in rural regions was lower than that of its national counterpart, but exhibited regional differences, mainly attributed to the dietary role of cereals. (ii) There existed significant spatiotemporal characteristics among regional food NFs that were mainly contributed by plant-derived food consumptions (73%). Sichuan, Henan, Shandong, and Hunan exhibited larger regional food NFs, and Beijing, Shanghai, and Tibet showed a growth in NFs, wherein rural diets were dominated by animal-derived food. (iii) Rural diets affected the environment by the pathways of ammonia and nitrous oxide volatilization processes, as well as Nr loss to water, accounting for a 33, 5, and 62% average of food NFs across regions. (iv) Although current rural dietary patterns suggest reliance on cereal and vegetable consumptions, more animal-derived types of food would be consumed as urbanization continues, especially in developed regions, creating a barrier for further reduction in national food NF.Conclusion: The findings of this study highlight the importance of changing dietary patterns to the human health-environment dilemma. Strategies that include improvements in N recycling rates, adjustments in dietary patterns, and reductions in food wastes could mitigate regional N pollution with rural dietary shifts.