bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients
Authors: Chen Yu-feng , Yu Zhao-liang , Lv Min-yi , Zheng Bin , Tan Ying-xin , Ke Jia , Liu Xuan-hui , Cai Ze-rong , Zou Yi-feng , Lan Ping , Wu Xiao-jian , Gao Feng 
Published: June 2021

Background: Hypoxia is associated with a poorer clinical outcome and resistance to chemotherapy in solid tumors; identifying hypoxic-related colorectal cancer (CRC) and revealing its mechanism are important. The aim of this study was to assess hypoxia signature for predicting prognosis and analyze relevant mechanism.Methods: Patients without chemotherapy were selected for the identification of hypoxia-related genes (HRGs). A total of six independent datasets that included 1,877 CRC patients were divided into a training cohort and two validation cohorts. Functional annotation and analysis were performed to reveal relevant mechanism.Results: A 12-gene signature was derived, which was prognostic for stage II/III CRC patients in two validation cohorts [TCGA, n = 509, hazard ratio (HR) = 2.14, 95% confidence interval (CI) = 1.18 – 3.89, P = 0.01; metavalidation, n = 590, HR = 2.46, 95% CI = 1.59 – 3.81, P &lt; 0.001]. High hypoxic risk was correlated with worse prognosis in CRC patients without adjuvant chemotherapy (HR = 5.1, 95% CI = 2.51 – 10.35, P &lt; 0.001). After integration with clinical characteristics, hypoxia-related gene signature (HRGS) remained as an independent prognostic factor in multivariate analysis. Furthermore, enrichment analysis found that antitumor immune response was suppressed in the high hypoxic group.Conclusions: HRGS is a promising system for estimating disease-free survival of stage II/III CRC patients. Hypoxia tumor microenvironment may be via inhibiting immune response to promote chemoresistance in stage II/III CRC patients.
Novel Prognostic Biomarkers in Gastric Cancer: CGB5, MKNK2, and PAPPA2
Authors: Qin Min , Liang Zhihai , Qin Heping , Huo Yifang , Wu Qing , Yang Huiying , Tang Guodu 
Published: June 2021

IntroductionGastric cancer is one of the most common malignant tumors of the digestive tract. However, there are no adequate prognostic markers available for this disease. The present study used bioinformatics to identify prognostic markers for gastric cancer that would guide the clinical diagnosis and treatment of this disease.Materials and MethodsGene expression data and clinical information of gastric cancer patients along with the gene expression data of 30 healthy samples were downloaded from the TCGA database. The initial screening was performed using the WGCNA method combined with the analysis of differentially expressed genes, which was followed by univariate analysis, multivariate COX regression analysis, and Lasso regression analysis for screening the candidate genes and constructing a prognostic model for gastric cancer. Subsequently, immune cell typing was performed using CIBERSORT to analyze the expression of immune cells in each sample. Finally, we performed laboratory validation of the results of our analyses using immunohistochemical analysis.ResultsAfter five screenings, it was revealed that only three genes fulfilled all the screening requirements. The survival curves generated by the prognostic model revealed that the survival rate of the patients in the high-risk group was significantly lower compared to the patients in the low-risk group (P-value &lt; 0.001). The immune cell component analysis revealed that the three genes were differentially associated with the corresponding immune cells (P-value &lt; 0.05). The results of immunohistochemistry also support our analysis.ConclusionCGB5, MKNK2, and PAPPA2 may be used as novel prognostic biomarkers for gastric cancer.
The Efficacy of a Virtual Reality Exposure Therapy Treatment for Fear of Flying: A Retrospective Study
Authors: Gottlieb Amihai , Doniger Glen M. , Hussein Yara , Noy Shlomo , Plotnik Meir 
Published: June 2021

Background: Fear of flying (FoF) is a phobia with 10–40% prevalence in the industrialized world. FoF is accompanied by severe economic, social, vocational, and emotional consequences. In recent years, virtual reality (VR)-based exposure therapy (VRET) for FoF has been introduced. Positive long-term efficacy of FoF-VRET has been reported by several studies, which, however, were limited by relatively small, non-representative samples and a lack of comparative pre/post functional efficacy outcome measures. Our objective was to evaluate the efficacy of a VRET treatment utilizing a large-scale VR system, experienced by a representative sample of self-referred individuals.Methods: We conducted a retrospective survey. Of 274 individuals who received the treatment (over a period of 3 years), 209 met inclusion/criteria, and 98 agreed to participate. We mainly collected information regarding flight activity before and after treatment relying on evidence such as boarding passes and flight tickets. The primary outcome measures were (1) number of flights per month (FpM) and (2) number of flight hours per month (FHpM). For each participant, these outcomes were computed for the post-treatment period (≥6 months after FoF-VRET) and the corresponding pre-treatment period.Results: FpM (mean ± SD) increased from 0.04 ± 0.06 to 0.16 ± 14 flights (p &lt; 0.0001). FHpM rose from 0.19 ± 0.35 to 0.79 ± 0.87 h per month (p &lt; 0.0001).Conclusion: These results are indicative of FoF-VRET treatment efficacy. Future studies should evaluate long-term maintenance of the treatment effect and thus identify the optimal frequency for delivery of periodic booster treatments.
Health professionals’ identified barriers to trans health care: a qualitative interview study
Authors: Mikulak Magdalena , Ryan Sara , Ma Richard , Martin Sam , Stewart Jay , Davidson Sarah , Stepney Melissa 
Published: June 2021

BackgroundTrans and gender-diverse people face multiple barriers within health care. Primary care practitioners are key to providing health care to trans and gender-diverse people but they often lack training in, and understanding of, trans identities and healthcare options. Few studies have examined health professionals’ understanding of the barriers that exist in health care for trans and gender-diverse people.AimTo map out barriers to providing good-quality health care to trans and gender-diverse people, and explore ways to address them.Design and settingA qualitative interview study involving 20 health professionals working with young trans and gender-diverse people.MethodParticipants were recruited through purposive and snowball sampling. Data were generated using semi-structured qualitative interviews. A thematic analysis involved coding and categorising data using NVivo (version 12) software and further conceptual analysis in which developing themes were identified.ResultsFour barrier domains to good-quality care for trans and gender-diverse people were identified: structural (related to lack of guidelines, long waiting times, and shortage of specialist centres); educational (based on lack of training on trans health); cultural and social (reflecting negative attitudes towards trans people); and technical (related to information systems and technology).ConclusionThere is an urgent need to address the barriers trans and gender-diverse people face in health care. Structural-level solutions include health policy, professional education, and standards; at the practice level, GPs can act as potential drivers of change in addressing the cultural and technical barriers to better meet the needs of their trans and gender-diverse patients.
The Concept of God in Siddha Literature
Authors: Janakiraman Ilamathy 
Published: June 2021

The people of this World could attain good conscience only by way of faith in God and the same was experienced and preached by the Siddhas. The Siddhas are aware of the loss of faith in God among the people due to various circumstances. So the Siddhas proclaims that the world has the power to create it, the divine attributes, the way of worship, and so on. The Kagapusunda Kaviya explains that “Shakti” appears through something called “Brahmam” and creates Siva and other deities in this World. During the period of destruction, again everything goes into “Shakthi”. All Siddhas says that the God is one and not many. That said divine one is set differently according to period, environment and place. The Siddhas explains in his poems/songs that the fake monks are deceiving the people by pretending them as God and don’t fell prey to the fakes and further the people can worship by performing the four precepts of Sariya, Kriya, Yoga and Gnanam and one can become a God by attaining Gnanan. This Article explains the above said concepts by quoting the poems of the Siddhas.
Devotional Theory in Comics
Authors: S Prabavathi 
Published: June 2021

Vedic and non-Vedic religions spread their ideas directly, through songs and sermons. A sense of devotion was sown by making a connection between God and Human. In particular, devotional literature is designed to convey the flexibility of the structural definitions of religions. This can be seen by examining the background of all the devotional literatures and religious epics. The reading method, which was in the state of “Telling – Listening” have been changed into the state of “Seeing – Reading”. Thus, there was a significant place for paintings and pictures in journalism. Paintings and pictures were considered as tools to impress the readers. So, the magazines had the custom of drawing up a chart for the stories. Religious institutions changed the forms of expression as time went on. All the myths and Epics of poems were made into prose stories after the advent of journalism. Stories created as a series of illustrations (Sequential Art) throughout were put forward to explain the doctrine of Devotion. “Amarchitra Katha” is a globally recognized magazine that symbolizes the Indian comic book tradition. Similarly, the magazine ‘Sri Ramakrishna Vijayam’ made a significant contribution in Tamil. All the stories published in this way have been published as pamphlets under the name of “Kathaimalar”. Thus, this Article explores the notion that 'such magazines, which are based on devotion, treat religious virtues especially from evidences of the Epics”. Further, this article goes on to point out the way in which these stories have carried the doctrine of Devotion of religious institutions to the contemporary generation.
Mempersoalkan Mediasi Sebagai Upaya Penyelesaian Disharmoni Peraturan Menteri
Authors: Akbar Rahmat , Yasin Ahmad 
Published: June 2021

Diaturnya mediasi dalam peneyelesaian disharmonisasi peraturan perundang-undangan dinilai tidak sesuai dengan prinsip hukum yang dianut di Indonesia. Mediasi biasa diterapkan dalam peneyelesaian masalah privat, namun diadopsi untuk menyelesaikan sangketa disharmonisasi norma hukum. hal tersebut menuai penolakan karena dianggap tidak sesuai dengan norma yang mengatur mediasi secara umum. Tulisan ini dibuat dengan tujuan untuk mengkritisi dan memberikan saran terhadap perbakaikan pengaturan mediasi. Metode penelitian yang digunakan adalah penelitian hukum normative. Dengan isu hukum bahwa terdapat ketidak sesuaian norma dan/atau prinsip hukum. dengan pendekatan peraturan perundang-undangan. Hasil penelitian ini bahwa terdapat ketidak sesuaian pengunaan mediasi dalam praktik di Indonesia. mediasi yang diterapkan dalam hukum privat dicoba untuk diadopsi dalam penyelesaian masalah regulasi hal tersebut mendapat penolakan. Selinitu tidak terdapat norma yang memerintahkan harmonisasi peraturan Menteri untuk diatur dalam Peraturan Menteri Hukum Dan Hak Asasi Manusia Nomor 2 Tahun 2019.
FEATURES OF TECHNOLOGY FOR PRODUCING MIXED BINDERS BASED ON SMALL NON-CONDITIONAL SANDS
Authors: Сайдумов М. С. , Джандаров А. Ш. , Муртазаева Т. С-А. 
Published: June 2021

В работе представлены результаты исследований некоторых особенностей получения смешанных вяжущих на основе мелких некондиционных песков. Разработаны теоретические положения повышения эффективности использования мелких песков в вяжущих путем их активации. Получены рецептуры смешанных вяжущих веществ на основе портландцемента, наполнителя из мелких песков и суперпластификатора «Мелфлюкс» и исследованы их основные технологические и физико-механические свойства. Работа выполнена в рамках исследований по реализации научного проекта № 18-48-200001 «Высококачественные бетоны с повышенными эксплуатационными свойствами на основе местного природного и техногенного сырья», получившего поддержку Российского фонда фундаментальных исследований» (РФФИ).
The paper presents the results of studies of some features of obtaining mixed binders based on fine substandard sand. Theoretical provisions have been developed to increase the efficiency of the use of fine sands in binders by activating them. Formulations of mixed binders based on Portland cement, a filler from fine sands and Melfluxsuperplasticizerwere obtained and their main technological and physicomechanical properties were investigated. The work was implemented as part of research on the fulfillment of scientific project No. 18-48-200001 “High-quality concrete with enhanced performance properties based on local natural and secondary raw materials,” which received support from the Russian Foundation for Fundamental Research (RFFR).
ORGANIZATION OF AN AUTOMATED SYSTEM SCIENTIFIC RESEARCH IN THE CONTROL AND TESTING OF MACHINES IN THE STRUCTURE OF THE PROCESS MONITORING SYSTEM
Authors: Шамсадова Я. Ш. , Игнатьев А. А. , Исаева М. Р. , Визирова Х. Р. 
Published: June 2021

В данной статье приведены данные об экспериментальных исследованиях динамических характеристик и испытаний станков, что позволяет получить важные результаты для анализа виброакустических колебаний, возникающих в основных формообразующих узлах, для идентификации и диагностирования. В качестве практической реализации элементов автоматизированной системы научных исследований можно привести комплекс автоматизированных измерительных средств, применяемых в системе мониторинга технологического процесса изготовления деталей подшипников.
This article presents data on experimental studies of dynamic characteristics and tests of machines, which allows us to obtain important results for the analysis of vibroacoustic vibrations that occur in the main forming nodes, for identification and diagnosis. As a practical implementation of the elements of an automated system of scientific research, we can cite a set of automated measuring tools used in monitoring the technological process of manufacturing bearing parts.
PRESERVATION OF THE ETHNOCULTURAL HERITAGE OF THE NORTH CAUCASUS PEOPLES AS A FACTOR OF ENSURING THE STATE SPIRITUAL SECURITY
Authors: Акаев В. Х. , Солтамурадов М. Д. , Акаев А. В. 
Published: June 2021

Этнокультурное наследие народов Северного Кавказа - значительно, многообразно, нередко и противоречиво. И оно придает региону, его народам пестрый, мозаичный облик, сложившийся в ходе его созидательной деятельности. В целом эта этническая и социокультурная реальность составляет основу определенного типа цивилизации, именуемой кавказской. Оно локально, колоритно, разнообразно, уникально, что определяется его материальными и духовными ценностями, оставившими предками подрастающим поколениям, а последние, внося свою лепту, придают наследию прошлого современный характер. Для многих современников этнокультурное многообразие непонятно, сложно, не потому, что оно архаично, а потому, что многообразно, испытав много веяний, исходивших от разных культур и цивилизаций. Сохранение этнического, культурного наследия народов Кавказа, осмысление для современности - исключительно важная в научном, культурологическом отношении проблема.
The ethnocultural heritage of the peoples of the North Caucasus is significant, diverse, often contradictory. And it gives the region and its peoples a colorful, mosaic appearance that has developed in the course of its creative activity. In general, this ethnic and sociocultural reality is the basis of a certain type of civilization, called the Caucasian. It is local, colorful, diverse, unique, which is determined by its material and spiritual values, which left the ancestors of the younger generations, and the latter, contributing, give the heritage of the past a modern character. For many contemporaries, ethnocultural diversity is incomprehensible, complex, not because it is archaic, but because it is diverse, having experienced many trends coming from different cultures and civilizations. The preservation of the ethnic and cultural heritage of the peoples of the Caucasus, comprehension for the present, is an extremely important problem in a scientific and cultural sense.
CONTEMPORARY RUSSIAN EDUCATION: INTERRELATION OF ETHNIC AND RELIGIOUS ASPECTS
Authors: Залибекова А. З. 
Published: June 2021

В статье рассмотрено содержательное становление этнического и религиозного аспектов в российском образовании как выработка у учащихся все обновляющихся понятий о ключевых человеческих добродетелях и качествах. Этот процесс предстает как фактор консолидации и единения народов. У дагестанских народов рассмотренные в статье качества подчеркивают их коллективистский менталитет, что особо значимо в условиях, когда ёмким и интегральным свойством современного человека предстает межэтническая, межнациональная и межконфессиональная толерантность. Процесс этот продолжается, несмотря на то, что реализация этноконфессионального потенциала народов в воспитании молодежи с каждым годом усложняется, встречает на своем пути не только объективные преграды глобализационных тенденций.
The article discusses the meaningful formation of ethnic and religious aspects in Russian education as the development of ever-renewing concepts among students about key human virtues and qualities. This process appears as a factor in the consolidation and unity of peoples. Among the Dagestan peoples, the qualities considered in the article emphasize their collectivist mentality, which is especially significant in conditions where interethnic, interethnic, and interfaith tolerance appear to be a capacious and integral property of modern man. This process continues despite the fact that the realization of the ethno-confessional potential of peoples in the upbringing of youth is becoming more complicated every year, it encounters not only objective obstacles to globalization trends.
FORMATION SECURITY TECHNOLOGY AND VULNERABILITYOF IOT
Authors: Хашумов И. У. , Хаджиев М. Р. , Мальцагов Х. Х. 
Published: June 2021

В данной статье рассматривается проблема информационной безопасности IoT и уязвимость в различных областях использования интернета вещей. В настоящее время мы можем найти статьи о том, как находят уязвимости, например, в такой технике, как автомобиль, холодильник или системах домашней сигнализации. Все эти вещи могут быть объединены одним термином IoT (Интернет вещей), и на сегодняшний день данная тема и данная технология является одной из самых популярных. Само название Интернет вещей (IoT) вызывает в воображении две противоречивые мысли: с одной стороны, это доступность и удобство управления любой техникой, с другой стороны, это опасность со стороны злоумышленников и хакеров, опасение за то, что, если все подключено к интернету, любой хакер может подключиться и навредить, изобретая множество способов проникновения в вашу жизнь с помощью ваших же гаджетов. В статье исследуются потенциальные риски и способы их снижения, необходимые учесть, прежде чем эксплуатировать устройства с поддержкой IoT.
This article addresses the issue of IoT information security and vulnerability in various areas of the use of the Internet of things. Currently, we can find articles on how to find vulnerabilities, for example, in such techniques as a car, a refrigerator or home alarm systems. All these things that can be united by one term IoT (Internet of things), and today this topic and this technology is one of the most popular. The very name of the Internet of Things (IoT) conjures up two conflicting thoughts on the one hand, it is the accessibility and convenience of controlling any technology on the other hand, it is a danger from intruders and hackers, the fear that everything is connected to the Internet, any hacker can connect and harm by inventing millions of ways to enter your life with your gadgets. The article examines the potential risks, and the likelihood of their reduction, before using devices with IoT support.
DETERMINING VIBROACOUS AND PART PROCESSING QUALITY ON AUTOMATED GRINDERS
Authors: Шамсадова Я. Ш. , Шамсадов Х. Ш. , Визирова Х. Р. 
Published: June 2021

В данной статье рассматриваются результаты испытаний внутришлифовальных станков SIW-4, для получения представления об уровне технологической надежности станков. Далее сформулированы рекомендации по ремонтно-профилактическим работам в случае его снижения, при испытаниях станков одной модели можно определить эталонный станок по качеству обработки и динамическому качеству, а затем наметить и реализовать в рамках системы мониторинга техно - логического процесса (СМТП) план мероприятий по повышению динамического качества станков до уровня эталонного.
This article discusses the results of tests of SIW-4 internal grinding machines, to get an idea of the level of technological reliability of the machines. Further, recommendations are formulated for repair and maintenance work in the event of its reduction, when testing machines of one model, you can determine the reference machine for processing quality and dynamic quality, and then plan and implement an action plan to improve the dynamic quality of machines to the standard level within the framework of the process monitoring system (SMTP).
TRADITIONS IN THE CONTEXT OF ETHNOS COGNITIVE ACTIVITIES
Authors: Нанаева Б. Б. 
Published: June 2021

В публикации анализируется роль традиций в познавательной деятельности, представляющей собой сложный, часто противоречивый процесс познания мира, на основе исторически сложившихся традиций. Важное место отводится традициям этноса, формирующими его мировоззрения, поведенческие установки, отношение к окружающему миру, образ жизни. Представляется необходимым рассмотрение этнокультурных традиций как важнейшую форму познания мира представителями этноса, в ходе которой вырабатывается его ментальные особенности, понимание социальной реальности, формируется соответствующий образ жизни.
The publication analyzes the role of traditions in cognitive activity, which is a complex, often contradictory process of understanding the world, based on historically established traditions. An important place is given to the traditions of the ethnos, which form its worldview, behavioral attitudes, attitude to the world around it, and way of life. It seems necessary to consider ethnocultural traditions as the most important form of cognition of the world by representatives of an ethnos, in the course of which its mental characteristics, understanding of social reality are developed, an appropriate way of life is formed.
ENVIRONMENTAL AND ECONOMIC PROBLEMS OF USING NATURAL RESOURCES OF THE WORLD ECONOMY
Authors: Чекрыжов А. В. , Сазонов В. А. 
Published: June 2021

В статье авторами рассматриваются основные экологические и экономические проблемы, имеющиеся в сфере использования природных ресурсов мирового хозяйства, такие как: исчерпание ресурсов, отсутствие возможности их пополнения; рост объемов потребления ресурсов населением; загрязнение окружающей среды. В связи с этим, важным становится оптимизация взаимодействия общества и природы на основе повышения эффективности использования природных ресурсов. Проанализированы авторами причины и факторы, сформировавшие на сегодняшний день кризисное положение в экологии.
In the article, the authors consider the main environmental and economic problems that exist in the use of natural resources of the world economy, such as the exhaustion of resources, the lack of opportunities to replenish them; the growth of resource consumption by the population; environmental pollution. In this regard, it is important to optimize the interaction of society and nature by increasing the efficiency of natural resources use.The authors have analyzed the reasons and factors that have formed the current crisis in ecology.