bluuebunny/crossref_metadata_2025_split huggingface dataset:
QSAR Docking on Azoles as Inhibitors of Notum Carboxylesterase
Authors: Sivaperuman Amuthalakshmi , Natarajan Ramalakshmi , P Manimegalai , Subramani Arunkumar , Ayarivan Puratchikody 
Published: October 2021

Background:
Carboxylesterase Notum is a negative regulator of Wnt signaling. Notum
carboxylesterase is a carboxylic ester hydrolase enzyme that functions as a negative feedback regulator
of Wnt proteins by depalmitoylation reaction. It is of great importance to understand the pathway
of Wnt regulation because, conversely, misregulation of Wnt signaling is a telltale sign of cancer
and other degenerative diseases. The Wnt inhibition is important in the control of colorectal cancer.

Objective:
In the present study, we carried out a QSAR analysis of a series of reported compounds
with carboxylesterase Notum inhibitory activity using multiple regression analysis. A series of 83
compound datasets of pyrrole derivatives with carboxy Notum inhibitory values were taken from
the reported literature.

Methods:
The study was performed by conducting multiple linear regression analysis followed by
validation of the model. The multiple linear regression (MLR) models with the highest coefficients
of correlation (R2) and explained variance in leave-one-out (Q2 LOO) prediction and leave- manyout
(Q2 LMO) were selected for the whole dataset. The developed models were subjected to internal
and external validation. The reliability of the predicted model was checked by plotting the Williams
plot. The docking methodology was performed using Autodock 4 for the designed compounds
to study the interaction between the ligand and the receptor.

Results:
The best model generated exhibited an r2 value of 0.7413, Q2LOO =0.6379, Q2LMO
=0.6368. Novel compounds of phenyl pyrrolidine were designed based on generated QSAR equations.
The carboxylesterase Notum inhibitory activity was predicted using the QSAR equations.
The docking studies were carried out for designed compounds using Autodock against Carboxylesterase
Notum esterase.

Conclusion:
From the results, the designed compounds were found to inhibit Notum Carboxylase.
Thus, the study led to the development of a novel lead compound for Carboxylesterase Notum.
Development of Instagram and YouTube Content Videos’ for Online Learning
Authors: Dewanti Septinda Rima , Sujarwo Sujarwo 
Published: October 2021

Instructional videos uploaded on Instagram and Youtube for online learning media teachers are facing a problem regarding the student's complicity in the learning process. To captivate the student's interest in the learning activity, the teacher needs to use innovative media. The study aims to develop an instructional video that is uploaded on Instagram and YouTube. The research used educational design research. The research procedure is 1) analysis of practical problems by the researcher; 2) development of prototype solutions informed by existing design principles; 3) testing and refinement. The study used questionnaires and interviews as the instrument. The number of subjects is 40 students The study results show that the video that was developed meets the criteria relevance, consistency, practicality, and effectiveness. The average score of the study is 3. The conclusion of the research is the instructional video uploaded on social media can improve students' activities in online learning. Recommendation for future study is to pay more attention to the urgency of instructional media in online education. Pengembangan Konten Video pada Instagram dan YouTube untuk Pembelajaran Daring Salah satu kendala pelaksanaan pembelajaran secara online adalah rendahnya keterlibatan mahasiswa. Pembelajaran dengan memanfaatkan media sosial diharapkan dapat meningkatkan minat belajar mahasiswa. Tujuan dari penelitian ini adalah untuk mengembangkan video pembelajaran yang dapat diunggah di media sosial Instagram dan YouTube. Metode penelitian yang digunakan pada penelitian ini adalah educational design research. Prosedur penelitian yang dilakukan meliputi 1) penelitian pendahuluan; 2) tahap pengembangan atau prototipe; 3) tahap asesmen/evaluasi. Instrumen penelitian yang digunakan adalah kuisioner dan pedoman wawancara. Jumlah subjek pada penelitian ini adalah 40 mahasiswa. Hasil dari penelitian ini adalah video pembelajaran yang dikembangkan memenuhi kriteria relevansi, konsistensi, kegunaan dan keefektifan yang ditunjukkan dengan rata-rata skor penilaian produk 3. Kesimpulan dari penelitian ini adalah media berupa video yang diunggah di media sosial, efektif membantu pelaksanaan pembelajaran daring bagi mahasiswa. Penelitian ini memberikan rekomendasi kepada peneliti selanjutnya terhadap urgensi penggunaan media pembelajaran yang menarik minat mahasiswa sehingga penelitian yang lebih mendalam tentang media pembelajaran perlu dilakukan.
Lipid Lowering and Hepatoprotective Activity of Premna Tomentosa Leaf Extract (EPT) against Alcohol Induced Toxicity in Rats
Authors: Dr. T. Gomathi Priyadharsini  , Dr. M. Kavimani  
Published: October 2021

The present study aims to determine the hepatoprotective and lipid lowering property of ethanolic leaf extract of Premna tomentosa (EPT) in alcohol induced hepatotoxicity. Chronic ethanol consumption is a significant danger factor in deciding liver disorders and other metabolic conditions through various mechanisms, including the regulation of the lipid metabolism. Medicinal plants are accepted to be a significant wellspring of new chemical substances with expected remedial impacts. Premna tomentosa (Verbenaceae) is a popular medicinal plant used extensively for the treatment of various ailments widely used in liver disorders. In the present research study, the male albino Wister rats were grouped (I-V) each consisting of 6 animals. In-vivo administration of 40 % ethanol (1 ml/100 gm b w/day) for 60 days resulted in a significant elevation in Total cholesterol, Triglycerides, LDL, and VLDL levels whereas the levels of HDL was found to be decreased when compared with the control rats. Liver tissues disclose central vein and sinusoidal capillary dilation, interface hepatitis, cytoplasmic vacuolization and mononuclear cell infiltration which confirms the intensity of liver damage due to chronic alcohol ingestion. Simultaneous EPT supplementation (500mg/kg and 750 mg/kg bw) to alcohol -intoxicated rats, reduced the levels of Total cholesterol, triglycerides, and lipoproteins consequential as analogized with the unsupplemented alcohol- treated rats. Liver of rats pre-treated with ethanolic extract of Premna tomentosa (500 mg and 750 mg) manifest reduced formation of interface hepatitis, vascular congestion, and fatty degeneration and exhibits more hepatoprotection compared with the rats pre-treated in Liv 52. The blood parameters were amplified by the histopathological perusal of the liver. The lipid -lowering property by the derivatives of cinnamic acid showed anticholesteremic activity. The results confirm the Hepatoprotective and lipid -lowering ability of Premna tomentosa in alcohol-treated rats.
Comparative Study on the Effects of Pelvic Floor Muscle Exercises and Abdominal Muscle Training in Functional Constipation among Children
Authors: Kamatchi.K  , Naveen kumar.S  , Tharani.G  , Yuvarani.G  , Deepa.I  , Meena.S  , Kaviraja.N  
Published: October 2021

To compare the effects of pelvic floor muscle exercise and abdominal muscle training, breathing exercisesandabdominal massage in children with functional constipation. Functional constipation is one the most common gastrointestinal condition in pediatrics practice with an estimation prevalence ranging from 0.7% to 29.6%. It has a multifactorial pathophysiology mainly consisting of stool with holding and delayed colonic transit.30 subjects who met theRome-III criteriafor pediatric functional constipationwere randomly divided into 2 groups. Group-A was trained with pelvic floor muscle exercise along with squat walking for 5 min under supervision of parents. Exercise duration was increased 5 min per week, for two consecutive weeks and remained the same for the next six weeks and Kegels was performed for 10 seconds. Group-B was given isometric training of the abdominal muscle which was carried out in two ways. The patient was either lying down in a left lateral decubitus position with the hip and knee flexed at 90° with two series of eight contractions and relaxations until the third week and was then increased to two series of 12 contractions and relaxations for 6 weeks. In the sitting or lying down method, training began with one series of three contractions and relaxations lasting 10 s which was increased to five repetitions in the third week until the sixth week along with abdomen tuck-in exercise. Diaphragmatic breathing and abdominal massage was given to both groups in common. The intervention of the study was about 8 weeks.Results of statistical analysis showed that both Pelvic Floor Muscle Exercises and Abdominal Muscle Training are effective in treating functional constipation among children. However pelvic floor muscle exercise was better than abdominal muscle training on the basis of Wexner Construction Scoring System.
Impact of Covid-19 on the Buying Behaviour of Consumers with Respect to Purchase of Medicines Through online and Retail Outlets
Authors: Srikanth Medimpudi  , Lucklin Medimpudi  , Lakshmana Rao Ayyagari  
Published: October 2021

The unprecedented impact of Novel Coronavirus Disease 2019 (COVID-19) on the economy is transforming consumer behaviour in purchasing various drugs. This study examines the change in consumer awareness levels and purchasing patterns concerning online pharmacies and generic drugs in the wake of the recent pandemic. It also explores the reasons behind changing attitudes, implications of these new consumer habits, and measures pharmaceutical retailers can take to evolve stronger. We conducted a cross-sectional survey of 260 randomly selected consumers attending a retail pharmacy attached to a secondary diabetes care centre in Andhra Pradesh from December 2020 to January 2021. The study involved 150 males and 110 females. We collected each consumer's demographic data, including age, gender, location, annual household income, and educational level. We used a questionnaire to assess consumers' awareness levels and buying patterns regarding online pharmacies and generic drugs, as well as their favored approaches to future shopping. In our study, 63.8% of subjects knew about online pharmacies, but 20.5% of them were aware only after the outbreak. Thirteen percent of consumers purchased medicines online, while 35.3% of them did so in response to the pandemic. On the other hand, 64.6% of the subjects know about generic medicines, but 8.3% of them have not heard of them until after the pandemic. Furthermore, consumers purchased generic medicines in 20.8% of cases, and 11.1% of those who purchased generics did so after the pandemic. In addition, we found that 79.2% opted for branded medicines in the future, while 56.9% chose local stores. 'COVID-19 lockdown brought a surge in awareness about online pharmacies and generic medicines, as well as a surge in online and generic purchases. Yet consumer sentiments towards local stores and branded medicines are positive during the COVID-19 times. The post-COVID-19 sentiment is as well looking optimistic for local stores and branded medicines.
Virtual Generation of Flexible Ring Tire Models Using Finite Element Analysis: Application to Dynamic Cleat Simulations
Authors: Siramdasu Yaswanth , Li Kejing , Wheeler Robert 
Published: October 2021

ABSTRACT
The main goal of this work is to investigate if finite element (FE) model techniques with special applications of material properties accurately estimate the parameters of flexible ring tire models. It is known that commercially available ring tire models are used as standard tools for simulating and predicting vehicle ride and durability, e.g., rigid ring MF-Swift [1] and flexible ring Flexible Structure Tire Model (FTire) [2–5]. Despite wide acceptance of these models, difficulty in model parameterization limits their application in the vehicle development process. For estimation of tire dynamic stiffnesses and inertial properties, rolling tire cleat test data are required for most ring models. Although this test method produces reliable models, the parameterization is not time and cost effective as it requires measurement and processing of cleat data at multiple speeds and loads and is prone to test rig dynamic compliance variations. This approach also limits the ability to evaluate tire performances during the virtual stages of tire design. The objective of this work is to develop virtual data using time and cost effective FE-based methods towards the estimation of flexible ring model parameters rather than relying on measured cleat data on physical tires. Commercial product ABAQUS is used for the FE simulations and FTire for tire flexible ring model simulations. Two FE modeling techniques are utilized in this work. Firstly, it is shown that the dynamic stiffness of a rolling tire can be estimated from a steady state eigensolution modal analysis of a static tire using material properties characterized for a rolling tire. Secondly, a method of separation of the sidewall from the tread band is developed for the estimation of mass and bending properties of the tread band. The estimated stiffnesses, inertias, and dimensions from the FE model results are converted into FTire model parameters. Finally, to validate the virtually generated FTire model, simulated dynamic cleat data response trends at multiple inflation pressures and velocities are compared with measurements. The virtual FE based techniques presented in this work can be applied to other ring based models as well.
Pengaruh Model Pembelajaran Kooperatif Tipe NHT Terhadap Hasil Belajar Bola Voli pada Peserta Didik Kelas XI SMA PGRI Seririt Tahun Pelajaran 2019/2020.
Authors: Eka Yogantara Putu , Panca Adi I Putu , Satyawan I Made 
Published: October 2021

Tujuan penelitian ini yaitu untuk mengetahui pengaruh model pembelajaran kooperatif tipe NHT terhadap hasil belajar teknik dasar passing bola voli. Jenis penelitian ini adalah eksperimen semu (quasi eksperimental) dengan menggunakan rancangan penelitian the non randomized control group pretest-posttest design. Subjek penelitian adalah peserta didik kelas XI MIPA dan XI IS SMA PGRI Seririt tahun pelajaran 2019/2020 sebanyak 53 peserta didik. Data hasil belajar dikumpulkan melalui pretest dan posttest. Analisis data menggunakan Uji-t dengan SPSS 16.0 for Windows. Eksperimen dilakukan sebanyak 3 kali perlakuan di luar pretes-posttest. Data hasil belajar dikumpulkan melalui tes objektif, observasi dan unjuk kerja. Pada kelompok eksperimen nilai pretest didapatkan rata-rata nilai 66,48 sedangkan kelompok kontrol 64,0. Hasil nilai posttest pada kelompok eksperimen didapatkan nilai rata-rata 82,76. Sedangkan Kelompok kontrol didapatkan nilai rata-rata 78,18. Rata-rata gain score normalisasi yang didapatkan pada masing-masing kelompok adalah pada kelompok eksperimen sebesar 0,5 sedangkan kelompok kontrol sebesar 0,4. Angka signifikansi yang diperoleh sebesar sig 0,001<0,05. Dari hasil penelitian dapat disimpulkan hasil belajar peserta didik yang di berikan perlakuan dengan menggunakan model pembelajaran kooperatif tipe NHT lebih meningkat dibandingkan dengan kelompok kontrol yang diberikan model pembelajaran konvensional. Model pembelajaran kooperatif tipe NHT berpengaruh signifikan terhadap peningkatan hasil belajar teknik dasar passing bola voli pada peserta didik kelas XI SMA PGRI Seririt.
IMPLEMENTASI MODEL PEMBELAJARAN KOOPERATIF TIPE STUDENT TEAMS ACHIEVEMENT DIVISION (STAD) UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR TEKNIK DASAR (SHOOTING) BERLANDASAN BUDAYA LOKAL
Authors: Suardika I Kadek , Setiawan Gede Hendri 
Published: October 2021

Penelitian ini bertujuan untuk meningkatkan aktivitas dan hasil belajar teknik dasar teknik dasar menendang bola (shooting) dalam permainan sepak bola pada peserta didik kelas XI IPA I SMA Negeri 1 Sukasada Tahun pelajaran 2018/2019 Penelitian ini tergolong penelitian tindakan kelas. Bentuk tindakan penelitian yang digunakan adalah peneliti sebagai guru. Pelaksanaan penelitian menggunakan 2 siklus yang masing-masing siklus terdiri dari tahap perencanaan tindakan, pelaksanaan tindakan, observasi/evaluasi, dan refleksi. Data dianalisis menggunakan analisis statistik deskriptif. Pada siklus I aktivitas dan hasil belajar siswa secara klasikal mencapai (5,6). Berdasarkan rentangan ketuntasan 0% -57% dan (80%), berdasarkan rentang ketuntasan 78% – 87% dalam katagori (baik). Pada siklus II, aktivitas dan hasil belajar siswa secara klasikal adalah mencapai (7,7) berdasarkan rentang ketuntasan75% - 77% dan 90%, berdasarkan rentang ketuntasan 88% – 100 % dalam katagori (sangat baik). Rata-rata aktivitas dan hasil belajar teknik menendang bola (shooting) adalah 91 (sangat aktif) Disimpulkan aktivitas dan hasil belajar teknik dasar menendang bola (shooting) meningkat melalui penerapan model pembelajaran kooperatif tipe Student Teams Achievment Division (STAD) pada Siswa Kelas XI IPA I SMA Negeri 1 Sukasada Tahun Pelajaran 2018/2019
EVALUASI PROGRAM PEMBINAAN PRESTASI CABANG OLAHRAGA PANAHAN DI BALI
Authors: Vanagosi Kadek Dian , Dewi Putu Citra Permana 
Published: October 2021

Penelitian bertujuan untuk mengetahui pelaksanaan program pembinaan prestasi cabang olahraga panahan di Bali dengan pendekatan evaluasi CIPP Model. Subyek penelitian meliputi pengurus, pelatih, atlet, dan masyarakat sekitar Pengkab/Pengkot se-Bali. Instrumen yang digunakan adalah angket dan pedoman wawancara. Didapat hasil pada dimensi context bahwa diperlukan adanya kerjasama antara pemerintah daerah dan masyarakat untuk berperan serta atif dalam mendukung keberadaaan Pengcab Perpani Kabupaten/Kota di Bali, sehingga bisa menjadi sentra pembibitan atlet panahan di Bali. Pada dimensi input masuk dalam kategori cukup baik, yang perlu dikembangkan adalah pemenuhan sarana dan prasarana latihan berupa tempat latihan khusus olahraga panahan, peralatan memanah pada masing-masing divisi serta sarana pendukung. Pada dimensi procces, pelaksanaan program mulai dari penyeleksian atlet, pengorganisasian, pelaksanaan latihan, program latihan dan evaluasi/monev masuk dalam kategori cukup baik. Hal yang perlu dikembangkan yaitu peningkatan kualitas pelatih dan wasit melalui penataran pelatihan pelatih dan wasit panahan. Pada dimensi product, hasil yang didapat dari program pembinaan yang telah dijalankan masih dalam kategori kurang. Hal yang perlu dikembangkan berkaitan dengan perkembangan fisik, teknik dan mental atlet. Kata-kata kunci: evaluasi, CIPP, pembinaan, panahan
PENERAPAN MEDIA TRAFIC LIGHT UNTUK MENINGKATKAN HASIL BELAJAR PENJASORKES PADA SISWA KELAS IXA6 SMP NEGERI 1 SINGARAJA TAHUN PELAJARAN 2018/2019
Authors: BAGIASA I KOMANG 
Published: October 2021

Melihat permasalahan yang dihadapi, dimana kondisi pembelajaran dalam aktivitas kebugaran jasmani yang berlangsung tidak sesuai harapan, peserta didik cenderung menunjukkan sikap kurang tertarik ketika menyelesaikan gerak yang ditugaskan dan menunjukkan hasil yang kurang memuaskan. Penelitian ini bertujuan untuk mengetahui hasil belajar siswa kelas IXA6 dalam proses pembelajaran pendidikan jasmani khususnya pada materi kebugaran jasmani dengan menggunakan media traffic light. Dalam penerapan pembelajaran yang menggunakan media traffic light terdapat peningkatan hasil belajar kebugaran jasmani siswa, hal ini dapat dilihat dari perbandingan hasil belajar pada siklus I dan siklus II. Nilai rata-rata (mean) pada siklus I sebesar 79,75 menjadi 89,14 pada siklus II, mengalami peningkatan sebesar 11,77% dan melampaui KKM. (KKM=80). Ketuntasan klasikal pada siklus I sebesar 70% menjadi 100% pada siklus II, mengalami peningkatan sebesar 30% dan sesuai kriteria ketuntasan klasikal(100%.). Dapat dinyatakan bahwa penggunaan media traffic light pada materi kebugaran jasmani dalam proses pembelajaran pendidikan jasmani olahraga dan kesehatan sangat efektif terbukti mampu meningkatkan hasil belajar siswa. Kata Kunci: media, trafic light
EVALUASI PROGRAM PADA KEJUARAAN ATLETIK PELAJAR BULANAN DINAS OLAHRAGA PROVINSI DKI JAKARTA
Authors: Muhammad Arifka Fadil , Asmawi Moch , Hernawan . 
Published: October 2021

Penelitian ini bertujuan mengevaluasi program Kejuaraan Atletik Pelajar Bulanan (KAPB) yang dilaksanakan Dinas Olahraga DKI Jakarta. Desain penelitian menggunakan model evaluasi CIPP (context, input, process, product) dengan rancangan penelitian evaluasi kualitatif. Program ini dilakukan di DKI Jakarta dengan menyertakan pelatih, atlet, manager dan semua komponen yang terlibat. Pengumpulan data menggunakan wawancara, studi dokumentasi, observasi dan angket yang menyertakan 66 responeden. Hasil penelitian menujukkan 46,97% responden menyatakan skema program KAPB sudah dikategorikan “baik”, 47,0% mengidentifikasi pemanfaatan sumber daya yang meliputi atlet, pelatih, sarana prasarana juga dikategorikan “baik”. Sebesar 43,9% menujukkan identifikasi proses pelaksanaan program KAPB dan peran tim monitoring evaluasi program dikategorikan “baik” serta 50,0% menyatakan pencapaian hasil pretasi para atlet dari serangkaian pelaksanaan program KAPB dikategorikan “baik”. Disimpulkan program evaluasi KAPB yang dibuat ini efektif untuk memantau program latihan dan mengukur keberhasilan program pemerintah untuk prestasi atlet pelajar di Provinsi DKI Jakarta.
Pengaruh Model Pembelajaran dan Motivasi Terhadap Hasil Belajar PJOK pada Siswa SMP
Authors: Adi Kesuma I Nyoman Agus , Yoda I Ketut , Hidayat Syarif 
Published: October 2021

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar PJOK antara siswa yang menggunakan model pembelajaran Kooperatif Tipe Jigsaw dan model pembelajaran konvensional serta mengetahui interaksi antara Model pembelajaran dan motivasi belajar terhadap hasil belajar PJOK di SMP Negeri 1 Blahbatuh. Jenis penelitian yang digunakan adalah experimental dengan rancangan “treatment by level” dengan dua ketegori 2x2. Sampel penelitian berjumlah 20 orang dipilih berdasarkan kategori motivasi belajar tinggi dan motivasi belajar rendah. Data dianalisis menggunakan analisis varian (ANAVA) dua jalur dengan taraf signifikansi 0,05. Hasil penelitian menunjukkan: 1) Hasil belajar PJOK pada siswa yang mengikuti pembelajaran kooperatif jigsaw lebih tinggi dibandingkan siswa yang mengikuti Model pembelajaran konvensional dengan nilai signifikansi 0,000 < 0,05, 2) Terdapat interaksi antara model pembelajaran dan motivasi belajar terhadap hasil belajar PJOK dengan nilai signifikansi 0,000 < 0,05, 3) Pada kelompok siswa dengan motivasi belajar tinggi hasil belajar PJOK siswa yang mengikuti model pembelajaran kooperatif tipe jigsaw lebih tinggi dari model pembelajaran konvensional dengan nilai signifikansi 0,000 < 0,05 dan 4) Pada kelompok siswa dengan motivasi belajar rendah hasil belajar PJOK siswa yang mengikuti model pembelajaran kooperatif tipe jigsaw lebih rendah dari model pembelajaran konvensional dengan nilai signifikansi 0,015 < 0,05. Dari hasil penelitian dapat disimpulkan bahwa model pembelajaran kooperatif tipe jigsaw dan motivasi belajar berpengaruh signifikan terhadap hasil belajar PJOK, sehingga dalam penerapan Model pembelajaran kooperatif tipe jigsaw hendaknya mempertimbangkan tingkat motivasi belajar siswa.