bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Antibacterial and Anti-biofilm Activities of Two Thiazolidione Derivatives (H2-60 and H2-81) Against Clinical Enterococcus Faecium Strains
Authors: Chen Zhong , Xiong Yanpeng , Tang Yuanyuan , Zhao Yuxi , Chen Junwen , Zheng Jinxin , Wu Yang , Deng Qiwen , Qu Di , Yu Zhijian 
Published: June 2021

Abstract
Background: Previous reports have demonstrated two thiazolidione derivatives (H2-60 and H2-81) can robustly inhibit the planktonic growth and biofilm formation of S. epidermidis and S. aureus by targeting the histidine kinase (HK) YycG. Whereas the antibacterial and anti-biofilm activity of these two thiazolidione derivatives (H2-60 and H2-81) against Enterococcus faecium remains elusive. Here, the YycG recombinant proteins containing HisKA and HATPase_c domain of E. faecium DO were in vitro expressed in E. coli competent cell BL21 (DE3) and then purified for the autophosphorylation test, indicating these two thiazolidione derivatives (H2-60 and H2-81) could directly impact the kinase phosphoration activity of YycG of E. faecium.Results: The MICs of H2-60 and H2-81 in the clinical isolates of E. faecium was in the range from 3.125mg/L to 25mg/L. Moreover, either H2-60 or H2-81showed the excellent bactericidal activity against E. faecium with the single dose or its combination with daptomycin (4 × MIC) by time-killing assay. Furthermore, over 90% of E. faecium biofilm formation could markedly be inhibited by two thiazolidione derivatives (H2-60 and H2-81) within 1/4×MIC value. In addition, the frequency of the eradicated viable cells embedded in mature biofilm were evaluated by the confocal laser microscopy, suggesting that of H2-60 combined with ampicillin or daptomycin was significantly high when compared with its monotherapy (78.17% and 74.48%vs.41.59%, respectively, P< 0.01). Conclusion: Two thiazolidione derivatives (H2-60 and H2-81) exhibit the robust antibacterial and anti-biofilm activity against E. faecium by targeting the histidine kinase (HK) YycG.
Development of an Efficient Gene-targeting System for Elucidating Infection Mechanisms of the Fungal Pathogen Trichosporon Asahii
Authors: Matsumoto Yasuhiko , Nagamachi Tae , Yoshikawa Asami , Yamazaki Hideki , Yamasaki Yusuke , Yamada Tsuyoshi , Sugita Takashi 
Published: June 2021

Abstract
Trichosporon asahii is a pathogenic fungus that causes severe, deep-seated fungal infections in neutropenic patients. Elucidating the infection mechanisms of T. asahii based on genetic studies requires a specific gene-targeting system. Here, we established an efficient gene-targeting system in a highly pathogenic T. asahii strain identified using the silkworm infection model. By comparing the pathogenicity of T. asahii clinical isolates in a silkworm infection model, T. asahii MPU129 was identified as a highly pathogenic strain. Using an Agrobacterium tumefaciens-mediated gene transfer system, we obtained a T. asahii MPU129 mutant lacking the ku70 gene, which encodes the Ku70 protein involved in the non-homologous end-joining repair of DNA double-strand breaks. The ku70 gene-deficient mutant showed higher gene-targeting efficiency than the wild-type strain for constructing a mutant lacking the cnb1 gene, which encodes the beta-subunit of calcineurin. The cnb1 gene-deficient mutant showed reduced pathogenicity against silkworms compared with the parental strain. These results suggest that an efficient gene-targeting system in a highly pathogenic T. asahii strain is a useful tool for elucidating the molecular mechanisms of T. asahii infection.
Rents, Administrative Sanctions and Conventional Corruption-Control Approach: Evidence from the Prevention of Corruption Act, India.
Authors: Perumal Kannan 
Published: June 2021

Abstract
This study challenges the argument that making it mandatory for the anti-corruption agencies to obtain prior administrative approvals from public authorities before detecting and prosecuting the corrupt can bring-in efficiency in corruption control. Applying the political economy concepts rents and rent seeking, this study explores the intricate relationships that exist between discretions available with the public authorities and their decisions to allow the anti-corruption enforcement to detect and prosecute public servants in corruption cases. Issue of similar facts getting differently appreciated by different public authorities has also been brought out by this study. This study argues that prior approvals by public authorities in high discretionary and low risk environments can promote rent seeking behaviour in public organizations. Findings of this study shows that limiting the discretions of authorities that decide administrative approvals and holding them accountable for their decisions can be the conditions critical for efficient anti-corruption enforcement in India.
An efficient sentiment analysis using topic model based optimized recurrent neural network
Authors: Pathik Nikhlesh , Shukla Pragya 
Published: June 2021

Abstract
In recent years, topic modeling and deep neural network-based methods have attracted much attention in sentiment analysis of online reviews. This paper presents a hybrid topic model-based approach for aspect extraction and sentiment classification of textual reviews. Latent Dirichlet allocation applied for aspect extraction and two-layer bi-directional long short-term memory (LSTM) for sentiment classification. This work also proposes a hill climbing-based approach for tunning model hyperparameters. The proposed model evaluated on three different datasets. Compared to the single-layer Bi-LSTM model, the proposed model gives 95, 95, and 86% accuracy for the movie, mobile, and hotel domain, respectively.
Flood risk assessment in Ya'an, Sichuan, China based on the emergy theory
Authors: Shu Xiaolong , Ren Yufeng , Duan Zhe , Liu Xing , Hua Xiaojun , Lei Huike 
Published: June 2021

Abstract
The emergy theory provides a new approach for flood risk assessment from an ecological perspective. By employing the emergy method, we used five indicators (rainfall runoff, medical workers and students per 10,000 people, social fixed assets investment, unit land GDP, and land-use types) from three dimensions (natural environment, population, and social economy) and the GIS technique to assess the potential impact and risk of a flood disaster on different regions in Ya'an City. Our findings revealed regional differences in the distribution of flood risks in Ya'an City: Lushan County and Yucheng District face the highest risks, followed by Tianquan County and Mingshan District, and Shimian County has the lowest risk. The index method was employed to analyze the regional differences. By training a back-propagation neural network with data on flood disasters in the study area, we produced a flood risk distribution map. We found that Mingshan District, Lushan County and Yucheng District have higher risks than other regions. The results largely agree with what we obtained using the emergy method. Our study shows that flood risk assessment based on the emergy theory can provide a scientific basis for flood control and disaster relief initiatives.
Better Heat and Power Integration of an Existing Gas-Oil Plant in Egypt Through Revamping the Design and Organic Rankine Cycle
Authors: Gadalla Mamdouh A. , Elmasry Alaa , Alhajri Ibrahim , Ashour Fatma H. , Elazab Hany A. 
Published: June 2021

Objective:
The current study aims mainly to Maximize Condensate Recovery (NGLs), focusing on a gas processing train of Gas-Oil Separation Plant (GOSP) located in Egypt with a capacity of 4,230 kmole/h.

Methods:
The research study accounts for the constraint of Reid Vapor Pressure (RVP) specification, which makes the storage in floating roof tanks is of a great risk. The study proposes the installation of the cryogenic train that recovers condensates (C4+). This train comprises of compression unit, expansion unit, three-phase separators and a re-boiled absorber. The problem of RVP will no longer exist because of the re-boiled absorber achieving RVP according to export specifications (RVP below 82.74 kPa). Heat integration is applied over the whole process to minimize the reliability of the external utilities. Further, an Organic Rankine cycle (ORC) is introduced to the existing unit for more heat integration to develop useful work from process waste heat. Furthermore, both environmental emissions of CO2 and economic implications are investigated.

Results:
Energy integration played a vital role in decreasing the compressing power by about 31%, the cooling load by about 81%, and eliminating the heating load leading to zero CO2 emissions.

Conclusion:
The new energy-integrated retrofit scenarios exceed the recommended revamping schemes by previous works and base case in all aspects of condensate recovery, energy-saving, environmental concerning and economics.
Formulation and Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumarate
Authors: Patel Keyur S. , Rao Akshar N. , Patel Deepa R. , Patel Dhaval M. , Patel Advaita B. 
Published: June 2021

The objective of the present study was to develop gastroretentive floating tablets of quetiapine fumarate. The gastroretentive floating tablets of quetiapine fumarate were formulated using natrosol 250 HHX as a sustained release polymer and sodium bicarbonate as a gas forming agents. A 32 factorial design was employed to study the influence of concentration of natrosol HHX 250 (X1) and concentration of sodium bicarbonate (X2) on the dependent variables % drug release at 1h (Y1), % drug release at 8 h (Y2) and floating lag time (Y3). The optimized formulation (O1) showed floating lag time 49 ± 3 sec and % drug release 99.54± 0.81 at 12 h. The in vitro release of F1-F9 batches were found in between 99.95 ± 1.18 % to 86.32 ±1.71 % at 12 h. Floating lag time of F1-F9 batches were found to be 25± 2 sec to 178 ± 3 sec. FTIR studies shown that there was no interaction between quetiapine fumarate and excipients. From the factorial design batches it was found that floating lag time was decreased with increasing the amount of sodium bicarbonate and decreasing the amount of natrosol 250 HHX. Here % release of drug was decreased with increase the extent of natrosol 250 HHX. The in-vitro release kinetics revealed Korsmeyer-Peppas model is followed and drug release is by anomalous diffusion.
Keywords: Quetiapine fumarate, Natrosol 250 HHX, Sodium bicarbonate, Gastroretentive floating tablets
Formulation and Evaluation of Lignocaine Hydrochloride Proniosomes Loaded Orabase for Dental Anaesthesia
Authors: G. V. Radha , MYNENI GANESH SAI , N Sunayana , G. V. R. L. Soujanya , K Charan 
Published: June 2021

The aim of this research is to prepare and evaluate lignocaine HCl Proniosomal orabase for enhanced permeation and prolonged dental anaesthesia effect. Objective: Various lignocaine proniosomal gels were formulated employing various surfactants. Methods: The formulations were scrutinized for entrapment efficiency, optical microscopy, in-vitro diffusion and release studies, mucoadhesive strength, ex-vivo permeation studies and drug – excipient interactions were determined by FTIR spectroscopy. Results: span 80 was found to be superior and significant for loading in to orabase. Considering the best entrapment efficiency with span 80 (91.60%) and optimum vesicle shape, along with prolonged drug permeation (33.6% for 24 h) the formulation F4 was selected and optimized for loading into orabase. The formulation F4 loaded orabase exhibited significant prolonged release over 10 h, and permeation profiles exhibited nearly two – fold increased flux in comparison with control. Good mucoadhesive strength was observed for proniosomal orabase 6273dynes/cm2, No evidence of incompatibility amongst formulation components from FTIR studies. SEM images revealed the particle size range from 50 μmt to 100 μmt for proniosomal orabase. Conclusion: Orabase can be an effective carrier for proniosomes with enhanced retention time at the site of application and provide prolonged release for oro-dental conditions.
Keywords: lignocaine Hcl, Oro-dental anaesthesia, Proniosomal gel, Orabase, Entrapment efficiency, prolonged release.
In-Situ Forming Polymeric Drug Delivery Systems for Ophthalmic Use: An Overview
Authors: Chhetri Pranal , Chakraborty Prithviraj , Das Debasmita , Afnan Tamanna 
Published: June 2021

Delivery of drug into the ocular region is hindered by the protective layers that encapsulate the eyes, it has always been a major problem to get an effective bioavailability of the active drug in the ocular region due to the low precorneal resident time of most of the ocular delivery systems specifically convention once such as ointment, solution and suspension, as a result, most of the delivery systems are not capable of effectively treating ocular diseases. Several works have and are being carried out to overcome this problem one of which is using in-situ forming polymeric systems. Ocular In-situ gelling systems are a novel class of ocular drug delivery systems that are initially in a solution form but instantaneously gets converted into a viscous gel upon introduction or installation in the ocular cavity from which the active drugs get released in a sustained manner. This sol-to-gel phase transition depends upon various factors like change in pH, ion presence and change in temperature. Gel formed after the transformation has preferred viscosity along with bio-adhesive property, which increases the gel’s resident time in the ocular area and also releases the drug in a prolonged and sustained manner unlike conventional eye drops and ointments. This review emphasizes various ocular in-situ systems namely, pH triggered, Ion activated, and Temperature triggered systems which have prolonged residence time in the cul-de-sac area of the eye, hence increasing the ocular bioavailability.
Keywords: In-situ gel, Ocular Drug delivery, Ocular Bioavailability, Polymer
Potential of Allium cepa in thromboembolism in Ulcerative Colitis in Rats
Authors: Ige Serah Funke , Adekola Aminat Aderayo 
Published: June 2021

Colitis and coagulation influence each other and patients with colitis have been reported to have an increased risk of thromboembolic events. Allium cepa has been reported to have anti-coagulative activity and anti-inflammatory activity. This research was carried out to investigate the effect of Allium cepa on coagulation changes in colitis
Twenty eight rats weighed 180 ± 20g were used for this study. They were divided into four groups; Control group, Colitis group, Allium Cepa + Colitis group and Allium Cepa group. Allium Cepa + Colitis group and Allium Cepa were given 1ml/100g body weight of Allium cepa extract daily for 28days orally. Colitis was induced by a single dose of intra-rectal administration of 1ml/100g body weight of 6% acetic acid. Forty eight hours after the colitis induction, blood was taken by cardiac puncture for clotting time test, Prothrombin time (PT), Partial thromboplastin time with kaolin test (PTT.K), platelet count, Calcium ion and Potassium ion test.
Calcium ion was significantly decreased while potassium ion, platelet count, significantly increased and partial thromboplastin time shortened in colitis animals when compared with control. Calcium ion, potassium ion, platelet count and partial thromboplastin time showed no significant difference in Allium Cepa + Colitis group when compared with control. It can be concluded that Allium cepa has potential to reduced the risk of thromboembolism in colitis
Keywords: Colitis, Allium cepa, thromboembolism
O Corpo Racializado nos Muros da Cidade: imagem e decolonialidade nas intervenções urbanas de Éder Oliveira
Authors: Viviani Maria Cristina Simoes , Morais Rômulo Fonseca 
Published: June 2021

A obra do artista contemporâneo paraense Éder Oliveira cria ressonâncias com o imaginário popular sobre os corpos racializados que pinta monocromaticamente nos muros da cidade de Belém do Pará. Este artigo traça paralelos entre autores decoloniais e o contexto brasileiro a partir da análise da obra de Oliveira. Ao esboçar as singularidades de seu trabalho, procuramos refletir sobre as potencialidades que este tem de instigar e dialogar com seus interlocutores, principalmente na problematização do racismo estrutural presente na sociedade brasileira. A partir dessa reflexão, buscamos ressaltar o importante viés crítico que a arte contemporânea exposta e acessível na cidade pode assumir na descolonização dos olhares e percepções sobre estes corpos.Palavras-Chave: Decolonialidade. Corpo. Imagem. Arte. Urbano. THE RACIALIZED BODY ON THE WALLS OF THE CITY:IMAGE AND DECOLONIALITY IN URBAN INTERVENTIONS BY ÉDER OLIVEIRA Abstract: The work of the contemporary artist Éder Oliveira from Pará, Brazil, creates resonances with popular imagination regarding bodies seen in a racial light that he paints in monochromatic murals in Belém, the capital city of his home state. This article draws parallels between decolonial authors and the Brazilian context from the analysis of Oliveira's work. When sketching the singularities of his work, we attempt to reflect on the potential it has to instigate and talk to the audience, especially on the problem of structural racism present in Brazilian society. From that reflection, we strive to highlight the important critical bias that contemporary art, when exposed and accessible throughout the city, can achieve when it comes to decolonizing the sights and perceptions on those bodies.Keywords: Decoloniality. Body. Image. Art. Urban.
Kontribusi Minat Belajar Dan Kompetensi Kepribadian Guru Terhadap Hasil Belajar Pada Mata Diklat Seni Grafis Jurusan Multimedia di SMK Negeri 1 Kecamatan Luak
Authors: Bukharla Isranika , Naansah Zulkifli , Jaya Putra 
Published: June 2021

This study aimed to determine the contribution of learning interest and personal competence of teachers toward student’s grade for Graphic Arts subject at X class of Multimedia Department at SMK Negeri 1 Kecamatan Luak. The type of this research is a descriptive correlational. Population in this research are 65 students, and samples are amount to 39 students. Samples are taken by simple random sampling technique. Student’s grade data obtained from teacher’s of graphic arts at SMK Negeri 1 Kecamatan Luak. And data of learning interest and personal competence of teachers were collected through a questionnaire using a Likert scale that has been tested for validity and reliability. The results of data analysis showed: (1) Learning interest and personal competence of teachers together contributed 61.5% for student’s grade, (2) Learning interest contributed 17.14% for student’s grade, (3) Competence teacher's personality contributed 16.64% for student’s grade. This research suggest that student’s interest in learning and personal competence of teachers give contribution to student’s grade.
Analisis Performance Jaringan 2G Global System For MobileComunication (GSM) Frekuensi 900 MHz dan 1800 MHz Berdasrkan Data Drive Test di PT. Telkomsel Padang
Authors: Pratama Putra Kenny , Faiza Delsina , Huda Yasdinul 
Published: June 2021

This research was motivated by a decline in performance on the BTS Batang Marau, which indicates the level of Rx Level, Rx Qual and SQI not meet KPI targets, so the presence of the area around the base stations that do not meet the standard Rx Level to make phone calls (blankspot). The purpose of this study was to determine the performance of GSM 900 and 1800 networks, as well as to improve the performance of base stations Batang Marau Power Link Budget calculation method. This study discusses the improving performance of GSM network at the site decreased performance, where performance is observed through measurement results based on the data drive test. The results of data analysis showed : (1) From the analysis, GSM 1800 already meet KPI targets for Rx Level >95 %, Rx Qual >94 % and SQI >93 %. In GSM 900 results analysis and Rx Qual SQI already meet the target KPI Rx Qual >94 % and SQI >93 %, while the results of the analysis of Rx level at 09.00 already reached the target KPI >95 %, at 15:00 and 20:00, still has not reached the target KPI <95 %, which indicates the time of measurement using tools Tems Investigation, there are several areas that Rx the level of poor quality. (2) Value Rx level in the area around the base stations are <-95 dBm indicates blankspot area (can lead to a drop call). (3) The estimated increase in performance on the GSM network by the method of link power budget on the BTS Batang Marau shows 69.3 dBm Rx Level (Good quality) at a distance of 2.5 km, so it can be concluded that the performance of GSM 900 base stations have been increased Batang Marau performances.
Pemanfaatan Jejaring Sosial Sebagai Media Pendukung Proses Pembelajaran Teknologi Informasi Dan Komunikasi di Sekolah Menengah Atas Negeri 4 Payakumbuh
Authors: Nidya Stephanie Kiki , Slamet Legiman , Jufri Ahmad 
Published: June 2021

This study specifically aims to determine the use of facebook amongst students of SMAN 4 Payakumbuh, and to investigate the students' response to the use of facebook as a medium of learning support. This study uses a descriptive study, in which only describe a situation or event does not explain the relationship and do not test hypotheses and make predictions. The study population was a tenth grade students of SMAN 4 Payakumbuh, semester 1. By using purposive sampling technique, class X4 obtained as a sample class. Data were obtained from the research literature (library research) and field research (field research) with a questionnaire instrument that contains 22 written statement, which must be answered by the respondents. A technique of data analysis in this research is to use the technique of percentage. The results showed that, in general, students of SMAN 4 Payakumbuh have regular and accustomed to using facebook, and for this use the facebook application just for fun. The research shows that the use of facebook as a medium of learning support have a positive impact for students, because not only students can play the facebook app, but can also use facebook as a medium for learning and discussion about learning. Keyword : facebook, media, descriptive
RANCANG BANGUN ANIMASI 3 DIMENSI SEBAGAI MEDIA PEMBELAJARAN PADA MATA PELAJARAN MENGINSTALASI PC
Authors: Yuningsih Febri , Hadi Ahmaddul , Huda Asrul 
Published: June 2021

One of the success of an organization of educators in implementing the learning is how educators attempt to deliver the message , and information theory to the students to understand the lessons and information more quickly and make the lessons more interesting and easier to understand, then educators need to create an exciting learning media such as media learning 3D animation ( three- dimensional ) . The purpose of this thesis is to design and build 3D animated instructional media on subjects Installing PC on Skills Program Computer Engineering and Networks . 3D animation creation using real-time , with the Pre-Production stages that include a search of ideas and materials will be made in 3D animation , character design , script, and storyboard creation , later stages of production , including the manufacture of modeling a design object / character , the next stage is the stage of post- production is a compilation of Final Editing and pengecekkan element if an error occurs then the process is repeated . Afterwards, proceed to the next stage of the rendering which will output the video as a whole . In the process of making 3D animsi using Blender 3D application version 2.6.5 . This final project will result in a medium of learning in subjects install the PC in the Program of Computer Engineering and Networks. Keywords : learning process , instructional media , 3D animation