bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional benefits of a chorioretinal anastomosis at 2 years in eyes with a central retinal vein occlusion treated with ranibizumab compared with ranibizumab monotherapy
Authors: McAllister Ian L , Smithies Lynne A , Chen Fred K , Mackey David A , Sanfilippo Paul G 
Published: March 2021

ObjectiveTo evaluate the functional benefits (best corrected visual acuity (BCVA), central subfield thickness, injection loads, central venous pressure (CVP)) of a laser-induced chorioretinal anastomosis (L-CRA) in patients with central retinal vein occlusion (CRVO) treated with ranibizumab compared with ranibizumab monotherapy.Methods and AnalysisThis is a post-hoc analysis of the 2-year randomised ranibizumab plus L-CRA for CRVO trial. Twenty-four patients (82.5%) developed a functioning or successful L-CRA; outcome effects were monitored in the monthly as-needed ranibizumab phase from months 7 to 24 and compared with the ranibizumab monotherapy group (n=29).ResultsFrom months 7 to 24, the mean (95% CI) injection load for the functioning L-CRA group was 2.18 (1.57 to 2.78) compared with 7.07 (6.08 to 8.06) for the control group (p<0.0001). The mean BCVA was averaged across all timepoints between the control and functioning L-CRA groups (average difference=11.46 (3.16 to 19.75) letters, p=0.01). At 2 years, there was an 82.5% reduction in the odds of high CVP (greater or equal to central retinal artery diastolic pressure) for those with a successful L-CRA compared with controls (p<0.0001).ConclusionFor patients with CRVO, adding L-CRA as a causal-based treatment to conventional therapy reduced CVP and injection loads and offered improved BCVA.Trial registration numberACTRN12612000004864.
Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade
Authors: Si Wei , Liang Hua , Bugno Jason , Xu Qi , Ding Xingchen , Yang Kaiting , Fu Yanbin , Weichselbaum Ralph R , Zhao Xin , Wang Liangliang 
Published: March 2021

ObjectiveOur goals were to evaluate the antitumour efficacy of Lactobacillus rhamnosus GG (LGG) in combination with immune checkpoint blockade (ICB) immunotherapies on tumour growth and to investigate the underlying mechanisms.DesignWe used murine models of colorectal cancer and melanoma to evaluate whether oral administration of LGG improves the efficacy of ICB therapies. We performed the whole genome shotgun metagenome sequencing of intestinal contents and RNA sequencing of dendritic cells (DCs). In a series of in vitro and in vivo experiments, we further defined the immunological and molecular mechanisms of LGG-mediated antitumour immunity.ResultsWe demonstrate that oral administration of live LGG augmented the antitumour activity of anti-programmed cell death 1 (PD-1) immunotherapy by increasing tumour-infiltrating DCs and T cells. Moreover, the combination treatment shifted the gut microbial community towards enrichment in Lactobacillus murinus and Bacteroides uniformis, that are known to increase DC activation and CD8+tumour recruitment. Mechanistically, treatment with live LGG alone or in combination with anti-PD-1 antibody triggered type I interferon (IFN) production in DCs, enhancing the cross-priming of antitumour CD8+ T cells. In DCs, cyclic GMP-AMP synthase (cGAS)/stimulator of IFN genes (STING) was required for IFN-β induction in response to LGG, as evidenced by the significant decrease in IFN-β levels in cGAS or STING-deficient DCs. LGG induces IFN-β production via the cGAS/STING/TANK binding kinase 1/interferon regulatory factor 7 axis in DCs.ConclusionOur findings have offered valuable insight into the molecular mechanisms of live LGG-mediated antitumour immunity and establish an empirical basis for developing oral administration of live LGG as a combination agent with ICB for cancer therapies.
Non-alcoholic fatty liver disease and increased risk of incident extrahepatic cancers: a meta-analysis of observational cohort studies
Authors: Mantovani Alessandro , Petracca Graziana , Beatrice Giorgia , Csermely Alessandro , Tilg Herbert , Byrne Christopher D , Targher Giovanni 
Published: March 2021

ObjectiveWe performed a meta-analysis of observational studies to quantify the magnitude of the association between non-alcoholic fatty liver disease (NAFLD) and risk of extrahepatic cancers.DesignWe systematically searched PubMed, Scopus and Web of Science databases from the inception date to 30 December 2020 using predefined keywords to identify observational cohort studies conducted in individuals, in which NAFLD was diagnosed by imaging techniques or International Classification of Diseases codes. No studies with biopsy-proven NAFLD were available for the analysis. Meta-analysis was performed using random-effects modelling.ResultsWe included 10 cohort studies with 182 202 middle-aged individuals (24.8% with NAFLD) and 8485 incident cases of extrahepatic cancers at different sites over a median follow-up of 5.8 years. NAFLD was significantly associated with a nearly 1.5-fold to twofold increased risk of developing GI cancers (oesophagus, stomach, pancreas or colorectal cancers). Furthermore, NAFLD was associated with an approximately 1.2-fold to 1.5-fold increased risk of developing lung, breast, gynaecological or urinary system cancers. All risks were independent of age, sex, smoking, obesity, diabetes or other potential confounders. The overall heterogeneity for most of the primary pooled analyses was relatively low. Sensitivity analyses did not alter these findings. Funnel plots did not reveal any significant publication bias.ConclusionThis large meta-analysis suggests that NAFLD is associated with a moderately increased long-term risk of developing extrahepatic cancers over a median of nearly 6 years (especially GI cancers, breast cancer and gynaecological cancers). Further research is required to decipher the complex link between NAFLD and cancer development.
Expression of programmed death-ligand 1 protein in pulmonary squamous cell carcinoma correlates with tumour necrosis but not with tumour differentiation
Authors: Tancoš Vladimír , Farkašová Anna , Kviatkovská Zuzana , Grendár Marián , Líšková Alena , Huťka Zdenko , Plank Lukáš 
Published: March 2021

AimsPulmonary squamous cell carcinoma (SqCC) represents the second most common non-small cell lung carcinoma type. The mechanisms which regulate programmed death ligand 1 (PD-L1) expression in this form of lung cancer are not fully elucidated yet.MethodsWe immunohistochemically determined the level of PD-L1 expression using the Tumour Proportion Score system in surgical resections of 133 patients with pulmonary SqCC. The results from PD-L1 immunohistochemistry were analysed in relation to tumour differentiation and the presence of necrotic areas comprising at least 20% of the tumour mass.ResultsNo significant differences in terms of PD-L1 expression were found between SqCC subtypes as defined by the current WHO classification: better differentiated, keratinising tumours (12/24, 50.0 %) compared with less differentiated, non-keratinising and basaloid forms (62/109, 56.9 %) were PD-L1 positive in a comparable proportion of cases (p=0.1903). Contrary to that, SqCCs with the presence of necrosis (51/61, 83.6 %) had significantly more PD-L1-positive cases (p<0.001) compared with SqCCs without necrotic areas (23/72, 32.0 %)ConclusionsWe demonstrated that PD-L1 expression in pulmonary SqCCs does not correlate with the traditionally defined degree of differentiation of these tumours. On the other hand, we found a significant association between the positive result of PD-L1 immunohistochemistry and tumour necrosis. Further investigation regarding the role of hypoxic pathways as presumable inducers of PD-L1 expression in pulmonary SqCCs might contribute to the understanding of this phenomenon.
Value of repeated imaging in patients with a stroke who are transferred for endovascular treatment
Authors: van Meenen Laura C C , Arrarte Terreros Nerea , Groot Adrien E , Kappelhof Manon , Beenen Ludo F M , Marquering Henk A , Emmer Bart J , Roos Yvo B W E M , Majoie Charles B L M , Coutinho Jonathan M 
Published: March 2021

BackgroundPatients with a stroke who are transferred to a comprehensive stroke center for endovascular treatment (EVT) often undergo repeated neuroimaging prior to EVT.ObjectiveTo evaluate the yield of repeating imaging and its effect on treatment times.MethodsWe included adult patients with a large vessel occlusion (LVO) stroke who were referred to our hospital for EVT by primary stroke centers (2016–2019). We excluded patients who underwent repeated imaging because primary imaging was unavailable, incomplete, or of insufficient quality. Outcomes included treatment times and repeated imaging findings.ResultsOf 677 transferred LVO stroke, 551 were included. Imaging was repeated in 165/551 patients (30%), mostly because of clinical improvement (86/165 (52%)) or deterioration (40/165 (24%)). Patients who underwent repeated imaging had higher door-to-groin-times than patients without repeated imaging (median 43 vs 27 min, adjusted time difference: 20 min, 95% CI 15 to 25). Among patients who underwent repeated imaging because of clinical improvement, the LVO had resolved in 50/86 (58%). In patients with clinical deterioration, repeated imaging led to refrainment from EVT in 3/40 (8%). No symptomatic intracranial hemorrhages (sICH) were identified. Ultimately, 75/165 (45%) of patients with repeated imaging underwent EVT compared with 326/386 (84%) of patients without repeated imaging (p<0.01).ConclusionsNeuroimaging was repeated in 30% of patients with an LVO stroke and resulted in a median treatment delay of 20 minutes. In patients with clinical deterioration, no sICH were detected and repeated imaging rarely changed the indication for EVT. However, in more than half of patients with clinical improvement, the LVO had resolved, resulting in refrainment from EVT.
Combined risk modelling approach to identify the optimal carotid revascularisation approach
Authors: Burke James Francis , Morgenstern Lewis B , Osborne Nicholas H , Hayward Rodney A 
Published: March 2021

BackgroundCarotid endarterectomy (CEA) results in fewer perioperative strokes, but more myocardial infarctions (MI) than carotid artery stenting (CAS). We explored a combined modelling approach that stratifies patients by baseline stroke and MI.MethodsBaseline registry-based risk models for perioperative stroke and MI were identified via literature search. We then selected treatment risk models in the Carotid Revascularisation Stenting versus Endarterectomy (CREST) trial by serially adding covariates (baseline risk, treatment (CEA vs CAS), treatment-risk interaction and age-treatment interaction terms). Treatment risk models were externally validated using data from the Society for Vascular Surgery (SVS) Vascular Quality Initiative (VQI) CEA and carotid stenting registries and treatment models were recalibrated to the SVS-VQI population. Predicted net benefit was estimated by summing the predicted stroke and MI risk differences with CEA versus CAS.ResultsPerioperative treatment models had moderate predictiveness (c-statistic 0.69 for stroke and 0.68 for MI) and reasonable calibration across the risk spectrum for both stroke and MI within CREST. On external validation in SVS-VQI, predictiveness was substantially reduced (c-statistic 0.61 for stroke and 0.54 for MI) and models substantially overpredicted risk.Most patients (86.7%) were predicted to have net benefit from CEA in CREST (97.0% of symptomatic patients vs 75% of asymptomatic patients).DiscussionA combined modelling approach that separates risk elements has potential to inform optimal treatment. However, our current approach is not ready for clinical application. These data support guidelines that suggest that CEA should be the preferred revascularisation modality in most patients with symptomatic carotid stenosis.
Multi-functional gallium arsenide photonic crystal polarization splitter with a gold core
Authors: Liu Chao , An Sinuo , Lv Jingwei , Yang Lin , Wang Famei , Liu Qiang , Li Xianli , Su Weiquan , Sun Tao , Chu Paul K. 
Published: March 2021

A multi-functional dual-core photonic crystal fiber (PCF) polarization beam splitter with a central oval hole filled with gold is designed and described. The first layer on the circular holes around the core is filled with the nematic liquid crystal (NLC) to enhance birefringence. The full-vector finite element method is employed to study the characteristics of the polarization beam splitter and derive the optimal parameters. When the fiber length is 14.55 [Formula: see text]m, the polarized light in the [Formula: see text]- and [Formula: see text]-directions can be separated at a wavelength of 1.31 [Formula: see text]m and the bandwidths are 257 and 238 nm, respectively, for extinction ratios bigger than 10 dB. When the fiber length is 10.86 [Formula: see text]m, the polarized light in the [Formula: see text]- and [Formula: see text]-directions can be separated at a wavelength of 1.55 [Formula: see text]m and the bandwidths are 239 and 174 nm, respectively for extinction ratios larger than 10 dB. The multifunctional polarization beam splitter with an ultra-short fiber length and broad bandwidth improves the sensing performance in comparison with single-function devices and our results provide insights into the design of beam splitters with multiple functions.
A Survey on Subgraph Counting
Authors: Ribeiro Pedro , Paredes Pedro , Silva Miguel E. P. , Aparicio David , Silva Fernando 
Published: March 2021

Computing subgraph frequencies is a fundamental task that lies at the core of several network analysis methodologies, such as network motifs and graphlet-based metrics, which have been widely used to categorize and compare networks from multiple domains. Counting subgraphs is, however, computationally very expensive, and there has been a large body of work on efficient algorithms and strategies to make subgraph counting feasible for larger subgraphs and networks.
This survey aims precisely to provide a comprehensive overview of the existing methods for subgraph counting. Our main contribution is a general and structured review of existing algorithms, classifying them on a set of key characteristics, highlighting their main similarities and differences. We identify and describe the main conceptual approaches, giving insight on their advantages and limitations, and we provide pointers to existing implementations. We initially focus on exact sequential algorithms, but we also do a thorough survey on approximate methodologies (with a trade-off between accuracy and execution time) and parallel strategies (that need to deal with an unbalanced search space).
Accuracy of the Informant Questionnaire on Cognitive Decline in the Elderly for Detecting Preexisting Dementia in Transient Ischemic Attack and Stroke
Authors: van Nieuwkerk Astrid C. , Pendlebury Sarah T. , Rothwell Peter M. ,   for the Oxford Vascular Study
Published: March 2021

Background and Purpose:
Prestroke dementia prevalence is high and impacts outcome. Although the IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly) is being used to assess prestroke cognition, data on its validity for prestroke dementia are lacking. We studied the accuracy of the short-form (16-item) IQCODE for pre-event dementia in a population-based study of all transient ischemic attack (TIA)/stroke.

Methods:
All patients with TIA/stroke in a defined population of ≈92 720 (Oxford Vascular Study, 2002–2017) with IQCODE were included. IQCODE questionnaires were given to participants at baseline interview with instructions to pass to an informant for completion and return by post. Diagnosis of pre-event dementia was defined as prior diagnosis of dementia, or dementia by the Diagnostic and Statistical Manual of Mental Disorders-IV criteria on study interview and hand-searching of the entire medical record blinded to IQCODE. Reliability of the IQCODE for dementia was determined by the area under the receiver operating characteristic curve, sensitivity and specificity, stratified by age, event severity, and first-ever stroke.

Results:

Among 2059 interviewed survivors, IQCODE were returned in 1068 (mean age/SD=72.9/12.3, 47% TIA, 52.3% male, 68 [6.4%] pre-event dementia). Area under the receiver operating characteristic curve for IQCODE for pre-event dementia was 0.94 (95% CI, 0.90–0.97,
P
<0.001) with similar results by age: 0.92, 0.88 to 0.96, <65 years; 0.94, 0.83 to 1.00, 65 to 74 years; 0.95, 0.92 to 0.99, 75 to 84 years; 0.89, 0.82 to 0.96, ≥85 years. The optimal cutoff score overall was >3.48 (sensitivity=89.7%; specificity=84.2%) but was nonsignificantly higher for major stroke (National Institutes of Health Stroke Scale score ≥3) than minor stroke/TIA (>3.85 versus >3.47). Performance was similar in patients with first-ever stroke (area under the receiver operating characteristic curve, 0.92 [0.88–0.97]; sensitivity=85.7%; specificity=84.8% for cutoff >3.48). All 16-IQCODE questions discriminated between dementia and no dementia (all
P
<0.001) with the greatest differences seen for finances, using gadgets, arithmetic, and learning new things.

Conclusions:
IQCODE has excellent accuracy for detecting preexisting dementia in TIA and stroke with the pattern of deficits suggesting prominent executive dysfunction.
Human Smuggling from Wollo, Ethiopia to Saudi Arabia: Askoblay Criminals or Enablers of Dreams?
Authors: Adugna Fekadu , Deshingkar Priya , Atnafu Adamnesh 
Published: March 2021

Abstract
Sensationalist accounts of human smuggling from Ethiopia towards Saudi Arabia allege that operations are controlled by criminal networks who converge in a variety of illegal markets posing a threat to national security. Such convergence narratives construct Ethiopian human smuggling as an organized criminal business that extracts profits from and inflicts violence on vulnerable people seeking a clandestine passage to work in the Gulf States. Our ethnographic research in Wollo, Ethiopia, challenges these narratives by showing that smuggling networks are developed through personalised relationships, based on co-ethnic bonds rather than extended and complex criminal networks. Smuggling has emerged in a particular context of surveillance and enforcement and the motives of smugglers are complex, making simple characterizations difficult. Smuggling is enabled by ethnic links on either side of the border where earnings from facilitation boost incomes in an otherwise impoverished context.
Coordinated Mobility: Disrupting Narratives of Convergence in the Irregular Migration of Youth from the Gaza Strip
Authors: Procter Caitlin 
Published: March 2021

Abstract
This article confronts the assumption that when irregular migration takes place in a context deemed to be terrorist, the two converge. The analysis is drawn from ethnographic fieldwork with young people engaged in the process of irregular migration from the Gaza Strip in occupied Palestine – a place often described as the largest open-air prison in the world. By analysing the process through which young people “coordinate” their movement out of Gaza, and their primary motivations for doing so, the article disrupts the idea of an incumbent criminal convergence of terrorism, irregular migration and human smuggling. It contributes to the growing literature which argues that, rather than operating with or through organized terrorist or criminal networks, the facilitation of irregular migration draws on improvised praxis. In the case of Gaza, it is also undertaken by youth in protest of the status quo of over twelve years of Israeli-Egyptian blockade of the Gaza strip, and the rule of the Hamas authority throughout this period. By attending to the experiences of youth in Gaza, the article explains the layers of economic and political agency that enable mobility in what is typically considered to be a highly immobile context.
An evaluation of size-resolved cloud microphysics scheme numerics for use with radar observations Part II: Condensation and evaporation
Authors: Lee Hyunho , Fridlind Ann M. , Ackerman Andrew S. 
Published: March 2021

AbstractAccurate numerical modeling of clouds and precipitation is essential for weather forecasting and climate change research. While size-resolved (bin) cloud microphysics models predict particle size distributions without imposing shapes, results are subject to artificial size distribution broadening owing to numerical diffusion associated with various processes. Whereas Part 1 addressed collision-coalescence, here we investigate numerical diffusion that occurs in solving condensation and evaporation. In a parcel model framework, all of the numerical schemes examined converge to one solution of condensation and evaporation as the mass grid is refined, and the advection-based schemes are recommended over the reassigning schemes. Including Eulerian vertical advection in a column limits the convergence to some extent, but that limitation occurs at a sufficiently fine mass grid, and the number of iterations in solving vertical advection should be minimized to reduce numerical diffusion. Insubstantial numerical diffusion in solving condensation can be amplified if collision-coalescence is also active, which in turn can be substantially diminished if turbulence effects on collision are incorporated. Large-eddy simulations of a drizzling stratocumulus field reveal that changes in moments of Doppler spectra obtained using different mass grids are consistent with those obtained from the simplified framework, and that spectral moments obtained using a mass grid designed to effectively reduce numerical diffusion are generally closer to observations. Notable differences between the simulations and observations still exist, and our results suggest a need to consider whether factors other than numerical diffusion in the fundamental process schemes employed can cause such differences.
Columbia University Master of Public Health Core Curriculum: Implementation, Student Experience, and Learning Outcomes, 2013-2018
Authors: Garbers Samantha , March Dana , Kornfeld Julie , Baumgartner Sabrina R. , Wiggin Maggie , Westley Lauren A. , Ballesteros-Gonzalez Diana , Delva Marlyn , Fried Linda P. 
Published: March 2021

Objectives: Public health education must respond to 21st-century public health challenges in an ever-evolving landscape. We describe implementation and educational outcomes of the Columbia University Master of Public Health (MPH) Core (hereinafter, Core) curriculum since its inception. Methods This retrospective evaluation combined 6 years (2013-2018) of student survey data collected from students (N = 1902) on the structure and delivery of the Core curriculum to quantify implementation, student experience, and learning outcomes, both during study (Core Evaluation Survey [CES]) and after graduation (Graduate Exit Survey [GES]). We used χ2 tests and analysis of variance to compare outcomes across years, and we used McNemar tests to compare differences in outcomes from the same students at different time points. Results Of 1902 respondents to the CES, 1795 (94.4%) completed the Core curriculum. During the study period, 81.7% of students were able to integrate concepts across Core curriculum modules with ease; postgraduation, a similar proportion of respondents were able to apply Core curriculum content to departmental and certificate coursework and applied field experiences. On-time graduation rates were high (range, 85%-93%). Conclusions: The high percentage of students who reported their ability to integrate concepts and who completed the Core during the study period likely reflected changes to teaching team structures, training, attention to inclusion and equity, and collaboration to implement active learning strategies. The Core curriculum meets its intended goals by providing critical learning abilities to support ongoing interdisciplinary work.