bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avoiding health technology assessment: a global survey of reasons for not using health technology assessment in decision making
Authors: Teerawattananon Yot , Painter Chris , Dabak Saudamini , Ottersen Trygve , Gopinathan Unni , Chola Lumbwe , Chalkidou Kalipso , Culyer Anthony J. 
Published: September 2021

Abstract
Introduction
Despite the documented benefits of using health technology assessments (HTA) to inform resource allocation in health care systems, HTA remains underused, especially in low- and middle-income countries. A survey of global health practitioners was conducted to reveal the top reasons (“excuses”) that they had heard from colleagues, policymakers or other stakeholders for not using HTA in their settings.

Methods
There were 193 respondents to the survey. Most responses were from individuals in research organisations (37%), ministries of health (27%) and other government agencies (14%). Participants came from Southeast Asia (40%), the Western Pacific (30%), Africa (15%), Europe (7%), the Americas (7%) and the Eastern Mediterranean region (2%).

Results
The top five reasons encountered by respondents related to lack of data, lack of technical skills for HTA, the technocratic nature of the work, the lack of explicit decision rules and the perception that HTA puts a “price on life”.

Conclusions
This study aimed to understand and address the top reasons for not using HTA. They fall into three categories: (1) misconceptions about HTA; (2) feasibility issues; and (3) values, attitudes and politics. Previous literature has shown that these reasons can be addressed when identified, and even imperfect HTA analyses can provide useful information to a decision-maker.
Study protocol for a type III hybrid effectiveness-implementation trial of strategies to implement firearm safety promotion as a universal suicide prevention strategy in pediatric primary care
Authors: Beidas Rinad S. , Ahmedani Brian K. , Linn Kristin A. , Marcus Steven C. , Johnson Christina , Maye Melissa , Westphal Joslyn , Wright Leslie , Beck Arne L. , Buttenheim Alison M. , Daley Matthew F. , Davis Molly , Elias Marisa E. , Jager-Hyman Shari , Hoskins Katelin , Lieberman Adina , McArdle Bridget , Ritzwoller Debra P. , Small Dylan S. , Wolk Courtney Benjamin , Williams Nathaniel J. , Boggs Jennifer M. 
Published: September 2021

AbstractBackgroundInsights from behavioral economics, or how individuals’ decisions and behaviors are shaped by finite cognitive resources (e.g., time, attention) and mental heuristics, have been underutilized in efforts to increase the use of evidence-based practices in implementation science. Using the example of firearm safety promotion in pediatric primary care, which addresses an evidence-to-practice gap in universal suicide prevention, we aim to determine: is a less costly and more scalable behavioral economic-informed implementation strategy (i.e., “Nudge”) powerful enough to change clinician behavior or is a more intensive and expensive facilitation strategy needed to overcome implementation barriers?MethodsThe Adolescent and child Suicide Prevention in Routine clinical Encounters (ASPIRE) hybrid type III effectiveness-implementation trial uses a longitudinal cluster randomized design. We will test the comparative effectiveness of two implementation strategies to support clinicians’ use of an evidence-based firearm safety practice,S.A.F.E. Firearm, in 32 pediatric practices across two health systems. All pediatric practices in the two health systems will receiveS.A.F.E. Firearmmaterials, including training and cable locks. Half of the practices (k= 16) will be randomized to receive Nudge; the other half (k= 16) will be randomized to receive Nudge plus 1 year of facilitation to target additional practice and clinician implementation barriers (Nudge+). The primary implementation outcome is parent-reported clinician fidelity to theS.A.F.E Firearmprogram. Secondary implementation outcomes include reach and cost. To understand how the implementation strategies work, the primary mechanism to be tested is practice adaptive reserve, a self-report practice-level measure that includes relationship infrastructure, facilitative leadership, sense-making, teamwork, work environment, and culture of learning.DiscussionThe ASPIRE trial will integrate implementation science and behavioral economic approaches to advance our understanding of methods for implementing evidence-based firearm safety promotion practices in pediatric primary care. The study answers a question at the heart of many practice change efforts: which strategies are sufficient to support change, and why? Results of the trial will offer valuable insights into how best to implement evidence-based practices that address sensitive health matters in pediatric primary care.Trial registrationClinicalTrials.gov,NCT04844021. Registered 14 April 2021.
High mean arterial pressure target to improve sepsis-associated acute kidney injury in patients with prior hypertension: a feasibility study
Authors: Dewitte Antoine , Labat Aurore , Duvignaud Pierre-Antoine , Bouche Gauthier , Joannes-Boyau Olivier , Ripoche Jean , Hilbert Gilles , Gruson Didier , Rubin Sébastien , Ouattara Alexandre , Boyer Alexandre , Combe Christian 
Published: September 2021

Abstract
Background
The optimal mean arterial pressure (MAP) in cases of septic shock is still a matter of debate in patients with prior hypertension. An MAP between 75 and 85 mmHg can improve glomerular filtration rate (GFR) but its effect on tubular function is unknown. We assessed the effects of high MAP level on glomerular and tubular renal function in two intensive care units of a teaching hospital. Inclusion criteria were patients with a history of chronic hypertension and developing AKI in the first 24 h of septic shock. Data were collected during two 6 h periods of MAP regimen administered consecutively after haemodynamic stabilisation in an order depending on the patient's admission unit: a high-target period (80–85 mmHg) and a low-target period (65–70 mmHg). The primary endpoint was the creatinine clearance (CrCl) calculated from urine and serum samples at the end of each MAP period by the UV/P formula.

Results
26 patients were included. Higher urine output (+0.2 (95%:0, 0.4) mL/kg/h; P = 0.04), urine sodium (+6 (95% CI 0.2, 13) mmol/L; P = 0.04) and lower serum creatinine (− 10 (95% CI − 17, − 3) µmol/L; P = 0.03) were observed during the high-MAP period as compared to the low-MAP period, resulting in a higher CrCl (+25 (95% CI 11, 39) mL/mn; P = 0.002). The urine creatinine, urine–plasma creatinine ratio, urine osmolality, fractional excretion of sodium and urea showed no significant variation. The KDIGO stage at inclusion only interacted with serum creatinine variation and low level of sodium excretion at inclusion did not interact with these results.

Conclusions
In the early stage of sepsis-associated AKI, a high-MAP target in patients with a history of hypertension was associated with a higher CrCl, but did not affect the kidneys' ability to concentrate urine, which may reflect no effect on tubular function.
Multitask adversarial attack with dispersion amplification
Authors: Haleta Pavlo , Likhomanov Dmytro , Sokol Oleksandra 
Published: September 2021

AbstractRecently, adversarial attacks have drawn the community’s attention as an effective tool to degrade the accuracy of neural networks. However, their actual usage in the world is limited. The main reason is that real-world machine learning systems, such as content filters or face detectors, often consist of multiple neural networks, each performing an individual task. To attack such a system, adversarial example has to pass through many distinct networks at once, which is the major challenge addressed by this paper. In this paper, we investigate multitask adversarial attacks as a threat for real-world machine learning solutions. We provide a novel black-box adversarial attack, which significantly outperforms the current state-of-the-art methods, such as Fast Gradient Sign Attack (FGSM) and Basic Iterative Method (BIM, also known as Iterative-FGSM) in the multitask setting.
Influence of permeability on the hydrothermal system at Vulcano Island (Italy): inferences from numerical simulations
Authors: Stissi Santina Chiara , Napoli Rosalba , Currenti Gilda , Afanasyev Andrey , Montegrossi Giordano 
Published: September 2021

AbstractVolcano-hydrothermal systems are governed by complex interactions between fluid transport, and geochemical and mechanical processes. Evidence of this close interplay has been testified by distinct spatial and temporal correlations in geochemical and geophysical observations at Vulcano Island (Italy). To understand the interaction between fluid circulation and the geochemical and geophysical manifestations, we perform a parametric study to explore different scenarios by implementing a hydro-geophysical model based on the equations for heat and mass transfer in a porous medium and thermo-poroelastic theory. Numerical simulations allow us to define the controlling role of permeability distribution on the different modeled parameters as well as on the geophysical observables. Changes in the permeability within the highly fractured crater area could be responsible for the fluctuations in gas emission and temperature recorded during the crisis periods, which are accompanied by shallow volcano-seismicity in the absence of significant deformation and gravity variations. Despite the general medium permeability of the volcanic edifice, the presence of more highly permeable pathways, which allow the gas to rapidly escape, as testified by the presence of a well-developed fumarolic field, prevents the pressure buildup at shallow depths.
Graphic abstract
The spatial diffusion of fertility decline in Egypt (1950–2006)
Authors: Doignon Yoann , Ambrosetti Elena , Miccoli Sara 
Published: September 2021

AbstractWhile the Egyptian fertility transition has been widely addressed in the literature, few researches have studied the spatial dimension of fertility. Using population census data, the aim of this study is to describe and measure the evolution of the geography of fertility on a subnational scale (qism/markaz), focusing on the period between 1960 and 2006. We assumed that the decline in fertility had spread spatially through Egypt, the spatial diffusion occurring through two traditional mechanisms: contagion and hierarchical diffusion. Our results confirm our hypotheses and highlight the importance of studying the spatial diffusion of the fertility transition. This study is unique for the Egyptian context given the long period and fine territorial scale considered. Our study constitutes an important addition to the existing group of studies on the spatial diffusion of fertility. Finally, it contributes to gaining further insight into a demographic dynamic which is fundamental for the future of Egypt.
Autoradiographic localization of [3H]-Nisoxetine binding sites in the CNS of male and female Japanese quail
Authors: Eaton Shannon E. , Pauly James R. , Hopkins Deann M. , Akins Chana K. 
Published: September 2021

Abstract
Background
In the central nervous system of mammals, transporters localized on the presynaptic nerve terminals regulate the reuptake of neurotransmitters. These transporters are selective for a specific neurotransmitter such as dopamine (DA) and norepinephrine (NE). Specifically in the synapse, the dopamine transporter (DAT) reuptakes DA and the norepinephrine transporter (NET) reuptakes NE. However previous research has found that avian species do not have a gene for DAT, and therefore, birds may be using the NET to clear both NE and DA from the synapse. The current study aimed to extend this finding by localizing NET expression in male and female Japanese quail (Coturnix japonica) brains using [3H]Nisoxetine, a selective NET blocker.

Results
High densities of binding sites were observed in the olfactory tubercle (OTu), the medial striatum (MSt), and the lateral striatum (LSt). Lower densities of binding sites were detected in the amygdala (AMY) and hypothalamus (Hyp), and low binding was found in the medial preoptic area (mPOA) and the pallium.

Conclusion
The areas with the highest densities of NET are also areas that previous research has shown to have high levels of DA activity but low levels of NE innervation (e.g. striatum). The distribution of this reuptake transporter is consistent with the theory that NET acts to clear both DA and NE from the synapse.
Virulence of four entomopathogenic nematode against different stages of the Mediterranean fruit fly, Ceratitis capitata Wiedemann (Diptera: Tephritidae)
Authors: Yağcı Mürşide , Akdeniz Fırat Tuğba , Erdoğuş F. Dolunay , Şahin Müge 
Published: September 2021

AbstractBackgroundCeratitis capitataWiedemann (Diptera: Tephritidae) (Mediterranean fruit fly), is one of the important polyphagous pest species in the world that harms almost all fruits causing significant yields losses. Control of this pest which is on the quarantine list of many countries is highly important. Due to the negative effects of chemical control on the environment and human health, biological control approaches have gained importance. Entomopathogenic nematodes (EPNs) are a potential biological control agent that can be used for effectively controlling the Medfly.ResultsIn this study, effects of four EPNs species on larvae, pupae and adults of Medfly were investigated under laboratory conditions. Four different concentrations of EPNs species were used against each stage of the pest. It pest showed different sensitivity to different concentrations of each of the tested EPNs. High mortality rate of 94% was caused byHeterorhabditis bacteriophora(11 KG),, followed byH. bacteriophora(TOK-20) with 91%,Steinernema carpocapsae(85%) andS. feltiae(Tokat-Emir) with 71% at highest concentration (200 IJ/larvae. The highest effect on adult mortality (100%) was recorded by the speciesS. feltiae(Tokat-Emir) at the highest concentration (200 IJ/adult) in the trials, followed byH. bacteriophora(11 KG) with 92%,H. bacteriophora(TOK-20) with 91% andS. carpocapsae(Tokat-Bakışlı05) with 87.37% mortality rates at the same concentrations.ConclusionsIt was determined that the EPNs tested in this study had insecticidal properties and they might be used in biological control programs against the Medfly.
A review of the health implications of heavy metals and pesticide residues on khat users
Authors: Oyugi Albert M. , Kibet Joshua K. , Adongo John O. 
Published: September 2021

AbstractBackgroundThere is an exponential rise in the use of farming chemicals in agricultural practices ostensibly to increase food production. The chewing of fresh khat leaves and shoots has spread across the world from ancient khat producing regions in East Africa and the Arabian Peninsula. Khat is a well-established socialization substance with stimulating characteristics. In this work, we have reviewed the deleterious impacts of several heavy metals such as lead, cadmium, iron in the khat plant and their health impacts. Survey on the health complications of farming chemicals used in khat production is also presented.Main body of the abstractThe toxic effects of heavy metals and farming chemicals in plant matter such as khat leaves are a serious health concern. Heavy metals including cadmium (Cd) and lead (Pb), for instance, bio-accumulate in the body and the food chain as precursors for disease. It has been established that blood that has lead levels of 40–60 ug/dL is a precursor for serious health illnesses such as cardiac arrest and cancer. On the other hand, cadmium is reported to bind itself onto metallothioneins hence forming cadmium–metallothionein complex that is transported to all body organs causing deleterious cell damage. The entry of farming chemical into the food chain especially via the chewing of contaminated khat has been known to contribute to health problems such as cancer, hypertension and liver cirrhosis. khat is branded a ‘substance of abuse’ by the World Health Organization (WHO) because of the adverse health risks it causes to humans. Relevant articles published between 2010 and 2021, and archived in PubMed, Google Scholar, Medley, Cochrane, and Web of Science were used in this review.Short conclusionThe health implications of heavy metals and farming chemicals arising from the consumption of contaminated khat shoots are a serious concern to the khat chewing community. Consequently, there is need to develop better farming practices that may minimize the absorption of heavy metals and farming chemicals by the khat plant. Information presented in this review is also important in sensitizing policy makers to advance control measures towards safer khat farming practices.
The antioxidant methyl gallate inhibits fungal growth and deoxynivalenol production in Fusarium graminearum
Authors: Liu Xin , Fang Xin , Wang Shuang , Wu Deliang , Gao Tao , Lee Yin-Won , Mohamed Sherif Ramzy , Ji Fang , Xu Jianhong , Shi Jianrong 
Published: September 2021

Abstract
Production of the Fusarium toxin deoxynivalenol (DON) is associated with oxidative stress and has been indicated to be part of an adaptive response to oxidative stress in the important wheat fungus Fusarium graminearum. In this study, we found that the antioxidant methyl gallate (MG) displays inhibitory effects against mycelial growth, conidial formation and germination, and DON biosynthesis in F. graminearum in a dose-dependent manner. Treatment with 0.05% (w/v) MG resulted in an abnormal swollen conidial morphology. The expression of the TRI genes involved in DON biosynthesis was significantly reduced, and the induction of Tri1-GFP green fluorescence signals in the spherical and crescent-shaped toxisomes was abolished in the MG-treated mycelium. RNA-Seq analysis of MG-treated F. graminearum showed that 0.5% (w/v) MG inhibited DON production by possibly altering membrane functions and oxidoreductase activities. Coupled with the observations that MG treatment decreases catalase, POD and SOD activity in F. graminearum. The results of this study indicated that MG displays antifungal activity against DON production by modulating its oxidative response. Taken together, the current study revealed the potential of MG in inhibiting mycotoxins in F. graminearum.

Graphical abstract
Association between body mass index and spatial gait parameters in primary school children
Authors: Elazeem Mohamed Rageh Abd , Eltohamy Amira Mohamed , Ali Mostafa Soliman 
Published: September 2021

Abstract
Background
Increasing BMI is associated with increased risk of mortality, cardiovascular disease, and some cancers whereas a lower BMI is associated with an increased risk of mortality, postsurgical complications, infection, and length of hospital stay as a result. Locomotion is a unique feature of the animal kingdom. It allows individuals to meet others, to find better food and a better climate, to pursue prey, or to escape impending danger. The aim of the current study was to determine the correlation between body mass index (BMI) and spatial gait parameters in primary school children.

Results
A total of 320 healthy children from primary schools were enrolled. The participants comprised 185 boys and 135 girls with a mean age of 10.05 ± 0.95 years, mean weight of 38.49 ± 12.2 kg, a mean height of 139.25 ± 10.12 cm, and a mean BMI of 19.35 ± 4.55 kg/m2. BMI was evaluated by the KINLEE Electronic Personal Scale with Height Measurement and CDC charts for boys and girls and equation of BMI. Spatial gait parameters were evaluated by a pediatric run-based anaerobic sprint test with an Omron pedometer to assess step and stride length.
Statistical analysis was performed by Pearson’s correlation coefficient to study the relationship between variables. A correlation was performed between the variables, and the coefficient of determination was calculated. The significance level was set at 5% for all analyses. There was no significant relationship between BMI and spatial gait parameters (step length and stride length) (r = 0.008, p = 0.88 and r = 0.02, p = 0.7, respectively).

Conclusion
According to the results, we concluded that there was no significant relationship between BMI and the measured gait parameters (step length and stride length).
Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations
Authors: Perret Mélanie , Lavallé Layla , Haesebaert Frédéric , Suaud-Chagny Marie-Françoise , Brunelin Jérôme , Mondino Marine 
Published: September 2021

Abstract

Background
Reality-monitoring process enables to discriminate memories of internally generated information from memories of externally derived information. Studies have reported impaired reality-monitoring abilities in schizophrenia patients with auditory hallucinations (AHs), specifically with an exacerbated externalization bias, as well as alterations in neural activity within frontotemporoparietal areas. In healthy subjects, impaired reality-monitoring abilities have been associated with reduction of the paracingulate sulcus (PCS). The current study aimed to identify neuroanatomical correlates of reality monitoring in patients with schizophrenia.

Methods
Thirty-five patients with schizophrenia and AHs underwent a reality-monitoring task and a 3D anatomical MRI scan at 1.5 T. PCS lengths were measured separately for each hemisphere, and whole-brain voxel-based morphometry analyses were performed using the Computational Anatomy Toolbox (version 12.6) to evaluate the gray-matter volume (GMV). Partial correlation analyses were used to investigate the relationship between reality-monitoring and neuroanatomical outcomes (PCS length and GMV), with age and intracranial volume as covariates.

Results
The right PCS length was positively correlated with reality-monitoring accuracy (Spearman’s ρ = 0.431, p = 0.012) and negatively with the externalization bias (Spearman’s ρ = −0.379, p = 0.029). Reality-monitoring accuracy was positively correlated with GMV in the right angular gyrus, whereas externalization bias was negatively correlated with GMV in the left supramarginal gyrus/superior temporal gyrus, in the right lingual gyrus and in the bilateral inferior temporal/fusiform gyri (voxel-level p < 0.001 and cluster-level p < 0.05, FDR-corrected).

Conclusions
Reduced reality-monitoring abilities were significantly associated with shorter right PCS and reduced GMV in temporal and parietal regions of the reality-monitoring network in schizophrenia patients with AHs.