bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of trans-mitral flow patterns and heart rate on intraventricular pressure gradients and E/E’ in the early stage of a rat model of hypertensive cardiomyopathy
Authors: Hirose Miki , Ma Danfu , Shimada Kazumi , Yoshida Tomohiko , Matsuura Katsuhiro , Kitpipatkun Pitipat , Hatanaka Akari , Zhao Yanbing , Takahashi Ken , Tanaka Ryou , Hamabe Lina 
Published: February 2025

BackgroundThe mitral inflow spectral is expressed as two separate waves: early diastolic trans-mitral flow velocity (E) and late diastolic trans-mitral flow velocity (A) waves. When the heart rate (HR) increases and the diastolic time diminishes, the mitral flow pattern changes from EA-separation to EA-fusion. The E wave provides information about preload and diastolic function. Tissue Doppler imaging (TDI) and non-invasive intraventricular pressure gradient (IVPG) based on color-M-mode echocardiography are two techniques established in recent years with good repeatability in cardiac function evaluation, especially diastolic.Hypothesis/objectiveWe hypothesize that IVPG and E/E’ are differentially influenced by mitral inflow patterns.AnimalsA total of 66 hypertensive cardiomyopathy (HTN-CM) induced by abdominal aorta coarctation and 33 sham-operated rats were divided into 6 groups according to trans-mitral flow patterns.MethodsConventional echocardiography, TDI, and IVPG sampling were performed on rats under general anesthesia with 2.5% isoflurane at 3 weeks after the operation. After code EA-separation = 1, EA-half-separation = 2, and EA-fusion = 3, Pearson’s correlation tests were performed.ResultsBoth E and E’ in EA-fusion (1.04 ± 0.13 and 7.65 ± 0.84) are higher than the EA-separation pattern in all rats (0.91 ± 0.10 and 5.51 ± 0.78, p &lt; 0.001). The preload change has more impact on E’ than E (0.443 vs. 0.218, p &lt; 0.001, respectively), which leads to decreased E/E’ in EA-fusion. Total IVPG and basal IVPG positively correlated with the mitral inflow pattern (0.265 and 0.270, p &lt; 0.001), while mid-to-apical IVPG was not (0.070, p = 0.281).ConclusionThe mitral inflow pattern positively correlates with basal IVPG, E, and E’. Mid-to-apical IVPG was independent of mitral inflow patterns, while E/E’ tended to be lower when the mitral inflow pattern changed from EA-separation to EA-fusion.
Impact of Climate Variability on Foodborne Diarrheal Disease: Systematic Review and Meta-Analysis
Authors: Gobena Tesfaye , Mengistu Dechasa Adare 
Published: February 2025

ObjectiveTo determine the impacts of climate variability on foodborne diarrhoeal disease worldwide.MethodsThis work was performed based on PRISMA guideline. Articles were retrieved from the PubMed, MEDLINE, Web of Science, Scopus, DOAJ, and Google Scholar. The search was made using Boolean logic operators, medical subject headings, and main keywords related to foodborne diarrheal disease. STATA version 17 was used to perform an analysis. The quality of the articles was evaluated using Joanna Briggs Institute appraisal tools.ResultsThe present study included 54 articles with an estimates of 103 findings. An increases in temperature, relative humidity, precipitation, rainfall, and flooding were associated with 4% [RR: 1.04; 95% CI: 1.03, 1.05], 3% [RR: 1.03; 95% CI: 1.01, 1.06], 2% [RR: 1.02; 95% CI: 1.01, 1.03], 1% [RR: 1.01; 95% CI: 1.00, 1.02], and 42% [RR: 1.42; 95% CI: 1.26, 1.57] increases in foodborne diarrhoeal disease, respectively.ConclusionThere was a significant association between foodborne diarrhoeal disease and climate variability, and indicate the need for building a climate-resilient food safety system to reduce foodborne diarrheal disease.Systematic Review Registrationidentifier CRD42024532430.
Management and surveillance of metastatic giant cell tumour of bone
Authors: Fellows David , Kotowska Julia , Stevenson Thomas , Brown Jennifer , Orosz Zsolt , Siddiqi Ather , Whitwell Duncan , Cosker Thomas , GIbbons Christopher L. M. H. 
Published: February 2025

Giant cell tumour of bone (GCTB) is viewed as a benign, locally aggressive primary bone tumour with metastatic potential. Current management is surgery with bone curettage or resection and systemic therapy with denosumab. Diagnosis is confirmed histologically prior to surgery, with staging for pulmonary disease, as pulmonary metastases (PM) reportedly occur in &lt;8%. This study aimed to assess incidence, surveillance and management of PM in patients with GCTB, with histopathological review. A retrospective audit of the Oxford bone tumour registry was performed from January 2014 – October 2023. Inclusion criterion was histological confirmation of GCTB. Exclusion criteria were incomplete medical, imaging or histology records, or referral for secondary MDT opinion for diagnosis. From an initial group of 126 GCTB patients, 83 patients met the full selection criteria. Pulmonary metastases were identified in 11 patients. Three with PM were excluded on histopathological review as being giant cell rich osteosarcoma rather than metastatic GCTB. This left 8 (9.6%) patients, one had PM at presentation and seven at follow-up between 2 and 42 months. Two were histologically confirmed after cardiothoracic surgery and biopsy, six radiologically diagnosed. Three (37.5%) patients with PM have died (between 1 and 12 months after confirmed PM), five are alive with stable disease. Seven (87.5%) of patients with pulmonary disease were treated with denosumab/chemotherapy (three before, four after pulmonary diagnosis). Five (62.5%) with pulmonary disease had recurrence of local disease requiring further surgery. Local recurrence was an independent risk factor for PM on statistical analysis. GCTB may present with PM, but more commonly, metastasis occurs after surgery, presenting on surveillance and can progress. There were no distinct differences in histopathological appearance between patients with GCTB that developed PM and those that did not, therefore morphological features of the tumour cannot be currently used to predict tumour behaviour. PM can behave aggressively, necessitating identifying histological markers to recognise patients at risk of metastatic GCTB, for example, through mRNA single cell analysis. We propose GCTB patients with PM receive regular chest surveillance with PET scan and/or CT to monitor disease progression, and a multi-centre audit of GCTB outcome undertaken to further define optimal clinical management.
Fly High: Volatile Organic Compounds for the Early Detection of the Seed-Borne Pathogen Curtobacterium flaccumfaciens pv. flaccumfaciens
Authors: Gaudioso Dario , Calamai Luca , Tegli Stefania 
Published: February 2025

The global demand for legumes has grown significantly since the 1960s, due to their high protein content and environmental benefits. However, this growth could also facilitate the spread of seed-borne pathogens like Curtobacterium flaccumfaciens pv. flaccumfaciens (Cff). Cff is a Gram-positive bacterium causing bacterial wilt in common beans and poses substantial challenges in regard to its detection and management, due to its long latent period and xylemic nature. Traditional diagnostic methods have proven insufficient, highlighting the need for innovative approaches. This study explores the potential of volatile organic compounds (VOCs) produced by Cff to be used as diagnostic markers to prevent the spread of seed-borne pathogens. First, we analyzed the VOCs emitted by different Cff strains in vitro, identifying a unique blend of five major VOCs. Subsequently, we verified the presence of these VOCs in vivo in artificially infected Cannellino beans. Phenylmethanol and 2-methoxy-4-vinylphenol emerged as key diagnostic markers, differentiating Cff from other bacterial pathogens of beans, such as Pseudomonas savastanoi pv. phaseolicola and Xanthomonas phaseoli pv. phaseoli. Our findings suggest that VOC fingerprinting offers a non-invasive, effective method for the early detection of Cff, even in asymptomatic seeds. This innovative approach holds significant promise for improving seed-borne disease management and supporting the development of practical diagnostic tools for field applications. Further research should aim to enhance the sensitivity and specificity of VOC-based diagnostics, facilitating the rapid and accurate screening of plant materials at ports of entry. This would contribute to the sustainability and health of leguminous crop production.
Bridging the Gap Between Platforms: Comparing Grape Phylloxera Daktulosphaira vitifoliae (Fitch) Microsatellite Allele Size and DNA Sequence Variation
Authors: Blacket Mark J. , Piper Alexander M. , Hoffmann Ary A. , Cunningham John Paul , Valenzuela Isabel 
Published: February 2025

Grape phylloxera, Daktulosphaira vitifoliae (Fitch), is an economically significant pest of grapevines. Identification of phylloxera genotypes is an important aspect of management as genotypes differ in virulence and susceptibility to control using resistant rootstocks. Microsatellite markers developed on polyacrylamide gel systems have been the most widely used molecular method for phylloxera genotype identification, but this approach has been superseded by fluorescent capillary-based genotyping. The current study presents new laboratory methods for amplifying a standard set of eight phylloxera microsatellite markers using PCR-incorporated fluorescently labelled primers, genotyped on an ABI capillary platform. Comparison of allele size data scored on (i) polyacrylamide, (ii) capillary, and (iii) high-throughput sequencing (HTS) platforms revealed that the capillary genotyping most closely matched the HTS allele sizes, while alleles of loci originally scored on a polyacrylamide platform differ in size by up to three base pairs, mostly due to the presence of previously uncharacterised DNA sequence indels. Seven common clonal lineages of phylloxera known from Australia are proposed as reference samples for use in calibrating genotyping systems between platforms and laboratories to ensure universal scoring of allele sizes, providing a critical link for accurately matching previous phylloxera genotype studies with current research.
Câncer de colo de útero no Pará: perfil epidemiológico entre os anos de 2013 e 2024
Authors: Silva Mayara dos Santos , Dias Karen Cristina de Miranda , Silva Cecília Gomes da , Srur Vitória Ribeiro Sabaa , Anjos Ana Vitória Soares dos , Telles Lucas Gabriel Xavier , Nascimento João Antonio Lopes do , Lopes Iracema dos Santos Silva 
Published: February 2025

O câncer do colo do útero (CCU) é o 3º câncer mais incidente em mulheres no Brasil, responsável por altos índices de morbimortalidade, mesmo sendo um dos principais temas de abordagem pela Atenção primária à saúde (APS). Analisar o perfil epidemiológico do CCU no Pará permite compreender a incidência, impacto e mortalidade desta patologia para identificar déficits no serviço de saúde e fomentar políticas eficazes de prevenção e destacar padrões específicos relacionados à população paraense, envolvendo determinantes que não são identificados em análises nacionais. Objetiva-se, assim, identificar o perfil epidemiológico do CCU no Pará entre 2013 e 2024. Para tanto, procede-se ao estudo de caráter epidemiológico, descritivo, quantitativo e retrospectivo dos casos de CCU no Pará, a partir de exames citopatológicos cérvico-vaginais de 2013 a 2024, com adequabilidade satisfatória, registrados no Sistema de Informação do Câncer - SISCAN, disponíveis no DATASUS. Observou-se no período pesquisado 2.013.337 exames citopatológicos cérvico-vaginais adequados no estado. Desses, 80.663 estavam alterados e 1.313 apresentaram malignidade, com predomínio do carcinoma epidermoide invasor. A faixa etária mais acometida foi de 40 a 44 anos e a distribuição geográfica variou entre municípios, destacando a necessidade de estratégias regionais. Houve subnotificação na escolaridade e disparidade racial, com maior incidência na raça "Amarela". Diante disso, é essencial fortalecer o rastreamento e políticas de prevenção, especialmente na Região Norte, onde a incidência do CCU é elevada.
Environmental Accounting-An Analytical Approach with special reference to India
Authors: Das Pradip Kumar 
Published: February 2025

Proclivity apropos global warming and environmental devastation worldwide has been big issue. Environmental accounting has appeared as an intrinsic mechanism for adjudging the financial aftermath of environmental sustainability, principally in nascent economy like India. Rationale for this study rests in growing environmental challenges and crappy tie-in of ecological costs into corporate accounts. Howbeit statues, challenges outlive in successful execution of environmental accounting systems. The central premise of this study is to reconnoitre the theoretical underpinnings of environmental accounting in India, examining its challenges, opportunities and preventive measures. A cognitive strategy has been echoed, enveloping an in-depth literature study, legislation, and corporate green reports to decipher mainstream techniques. The study further delineates bottom issues frinstance unstandardized reporting guidelines, limited corporate fervor, and lacuna in compliance oversight. To accost these challenges, the paper insinuates robust regulatory passivity, reformed exposure tenets, and implementation of all-inclusive accepted accounting policies conducive to India's socio-economic environment. Thereby, with getting rampant of environmental accounting, its acceptance continues incoherent and tricky. Notwithstanding scientists and politicians are sussing for environmental issues, corporate need receptive of that a resilient future postulates green accounting for them. The analysis demonstrates that a methodical and oversight model, beyond corporate commitment and stakeholder rendezvous, is indispensable for harmonizing ecological themes into lamestream accounting approached in India.
A hydrologic engineering analysis of a failed rangeland water control structure on the Buenos Aires national wildlife refuge
Authors: Dorsett Cameron K. , Slack Donald C. , Nichols Mary H. , Didan Kamel 
Published: February 2025

This report summarizes a hydrologic engineering analysis of a failed concrete drop spillway (broad-crested weir) water control structure at the outlet or “pour point” on the Buenos Aires National Wildlife Refuge (BANWR) watershed southwest of Tucson, AZ. The main objective was to determine the maximum flow the structure could pass without failure (discharge capacity) as well as the rainfall recurrence interval and duration which would result in a flood of a magnitude which would exceed the capacity of the spillway and thus likely lead to failure of the structure. The layout, function, and characterization of the watershed was established using modern software programs and available imagery. The discharge capacity of the concrete drop spillway was found to be 21.1 [m3s-1]. After evaluating results obtained from the Rational Method and the Curve Number (CN) Method (with assumptions of closed upper-watershed gates and stock pond retention having no effect), the spillway capacity was adequate to withhold runoff volumes generated from 10-yr to 25-yr recurrence interval rainfalls of variable durations and intensities provided the spatial extent of rainfall was limited to one of the two small sub-watersheds (Sub-watersheds A and B). However, if rainfall occurred over the entire watershed or Sub-watershed C then the spillway capacity was exceeded by runoff volumes generated for 10-yr and 25-yr recurrence interval rainfalls of all durations as well as all generated design storms of greater magnitude and intensity.
ANALISIS EFEKTIFITAS DAN KONTRIBUSI BEA PEROLEHAN HAK ATAS TANAH DAN BANGUNAN PADA PENDAPATAN ASLI DAERAH DI KABUPATEN BOGOR (Tahun 2017-2019)
Authors: Sundari Anugrah , Mukmin Mas Nur , Hambani Susi 
Published: February 2025

The pulrpose of this stuldy is to alnallyze the Effectiveness alnd Contribultion of Lalnd alnd Bulilding Rights Alcqulisition Dulty (BPHTB) on Regionall Originall Revenule (PAlD) in Bogor Regency in 2017 -2019. Qulallitaltive descriptive resealrch design ulsing daltal testing in the form of Effectiveness Alnallysis alnd Contribultion Alnallysis. Alnallysis of the Effectiveness of Lalnd alnd Bulilding Rights Alcqulisition Dulty (BPHTB) on Regionall Originall Revenule (PAlD) in Bogor Regency in 2017-2019 hals aln alveralge effectiveness ralte of 132.4%. This shows thalt the performalnce of the locall government of Bogor Regency in collecting Lalnd alnd Bulilding Rights Alcqulisition Dulty (BPHTB) talx on Regionall Originall Revenule (PAlD) is qulite good or inclulded in the very effective interpretaltion criterial als al percentalge of effectiveness of more thaln one hulndred percent. Alnallysis of the contribultion of Lalnd alnd Bulilding Rights Alcqulisition Dulty (BPHTB) to Regionall Originall Revenule (PAlD) in Bogor Regency in 2017-2019 hals aln alveralge contribultion ralte of 24.6%. This shows thalt the Alnallysis of the Contribultion of Lalnd alnd Bulilding Rights Alcqulisition Dulty (BPHTB) talx revenule to Regionall Originall Revenule (PAlD) in Bogor Regency in 2017-2019 is increalsing every yealr allthoulgh it is not too significalnt. This caln be caltegorized into the Mediulm criterion becalulse it is in the ralnge of 20.10% to 30%.

Keywords : Effectiveness, Contribultion, BPHTB, PAlD.
ANALISIS LAPORAN KEUANGAN BERDASARKAN RASIO LIKUIDITAS, RASIO SOLVABILITAS DAN RASIO RENTABILITAS UNTUK MENILAI KINERJA KEUANGAN PADA KOPERASI SIMPAN PINJAM BMT EL DANA MANFAAT BANDUNG PERIODE 2017 -2020
Authors: Bahari Kintan Rizki , Afif M. Nur , Melani Maria Magdalena 
Published: February 2025

A cooperative is a business entity consisting of individuals or legal entities, which carries out its activities by following cooperative principles and functions as a community economic movement that prioritises family principles. Cooperatives are a type of organisation that aims to achieve certain goals in order to meet the interests of its members. Evaluation of the performance of a cooperative or company is carried out to provide a basis for decision making, both by internal and external parties. Evaluation of good financial performance can be done by analysing the results that show a percentage in accordance with predetermined standards. To assess financial performance, a tool or method is needed that allows cooperative management to carry out its duties and responsibilities properly, and in accordance with the objectives of the cooperative in general. The tool used in this analysis is Ratio Analysis, which includes Liquidity Ratio, Solvency Ratio, and Rentability Ratio. This research utilises data from the cooperative's financial statements, including the balance sheet, income statement, and cash flow statement from the period 2017 to 2020, with a quantitative descriptive approach. The analysis technique applied is trend or tendency analysis. Data were collected through survey techniques, which included observation, documentation, and interviews. The purpose of this analysis is to describe or describe the results of the cooperative's financial statements, so as to better evaluate the cooperative's financial performance.

Keywords : financial statements, ratio analysis, liquidity ratios, solvency ratios, profitability ratios, and financial performance.
ANALISIS FAKTOR-FAKTOR PENYEBAB TIDAK TERCAPAINYA TARGET PENERIMAAN PAJAK BUMI DAN BANGUNAN DI KABUPATEN KOLAKA
Authors: Asriyana Desy , Ilham Surianto , Turi La Ode 
Published: February 2025

The purpose of this investigation is to identificate what factors are more dominant in causing the land and building tax revenue to not be achieved in Kolaka Regency from 2019-2023.his research is research using a qualitative descriptive method. This study was conducted at the Kolaka Regency Regional Revenue Agency. Both primary and secondary data sources were used in this study. Researchers used evidence and interviews to gather data. Gathering information, reduction of data, presentation of data, and reaching a conclusion are the methods of data analysis that are employed. The findings of the research show that the more dominant factor causing land and building tax revenues to not be achieved in Kolaka Regency from 2019-2023 is active resistance, namely the existence of taxpayers who try to avoid tax objects and passive resistance, namely the lack of economy which can make it difficult to pay taxes. earth and buildings.

Keywords: Factors Causing Non-achievement of Land and Building Tax Revenues
PENGARUH KOMPETENSI PENDAMPING DESA DAN PENGGUNAAN SISTEM KEUANGAN DESA TERHHADAP PENGELOLAAN KEUANGAN DESA
Authors: Djafarmaku Muhamad Ravie Raflyzal , Kusuma Indra Cahya , Susandra Farizka 
Published: February 2025

The aim of the research is to identify how the skills of village assistants and the use of the village financial system influence village financial management. A quantitative descriptive approach was used in the research process. Purposive sampling is the method used for sampling from 36 villages in Bogor Regency with a total sample of 109 village officials from each village. Data collection techniques through questionnaires. Multiple linear regression test and hypothesis test are the analysis methods used. Research findings show that in Bogor Regency, village financial management is simultaneously and partially influenced by the skills of village assistants and the use of the village financial system (SISKEUDES).

Keywords: Competence of village assistants, village financial system
ANALISIS KINERJA KEUANGAN DAN FINANCIAL DISTRESS PADA PT BANK MUAMALAT TBK
Authors: Liviawati Liviawati , Putri Gusmarila Eka , Wardi Jeni 
Published: February 2025

Pandemi Covid 19 yang meluluh lantakkan perekonomian Indonesia juga berimbas kepada perbankan Syariah. Selama covid, kinerja perbankan baik konvensional maupun syariah menurun, dimana hal ini dapat kita lihat dari salah satu indikator kinerja perbankan yaitu kualitas kredit yang ditandai dengan angka NPL/NPF yang terus meningkat. Bank Muamalat merupakan bank Syariah pertama di Indonesia. Dan pada tahun 2024 Bank Muamalat diberitakan diakuisisi oleh UUS BTN dengan tujuan untuk membentuk bank Syariah yang lebih besar. Tetapi di sisi lain Bank Muamalat sebagai pemegang saham terbesar pada BPKH (badan pengelola keuangan haji). Peneliti mencurigai akuisisi dilakukan untuk menyelamatkan Bank Muamalat khususnya untuk meningkatkan kinerja bank agar mampu memberikan penghasilan yang lebih baik kepada pemegang saham, karena berdasarkan pantauan kinerja keuangan Bank Muamalat dalam lima tahun terakhir tampak naik turun yang tergambar dalam laporan keuangan terbaru di tahun 2023 dimana bank muamalat memperoleh laba 13, 29 miliar yang merupakan penurunan laba yang sangat signifikan dibanding tahun 2022 yaitu mencapai 50%.
Penelitian ini bertujuan untuk menganalisis kinerja bank muamalat dan potensi finansial distress bank tersebut. Analisa data menggunakan analisis deskriptif dengan menghitung rasio keuangan. Hasil penelitian ini menunjukkan bahwa permodalan bank muamalat masih tergolong baik, tetapi profitabilitas yang rendah, dan tidak efisien, dan berpotensi mengalami kebangkrutan.