bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic, Genomic and Biophysical Case Study: Familial 46, XY Sex Reversal due to a Novel Inherited Mutation in Human Testis-Determining Factor SRY
Authors: Vaiani Elisa , Chen Yen-Shan , Ramirez Pablo , Racca Joseph , Baquedano Maria Sonia , Malosetti Carmen , Touzon Maria Sol , Marino Roxana , Costanzo Mariana , Bailez Marcela , Berensztein Esperanza , Galluzzo-Mutti Maria Laura , Chatterjee Deepak , Yang Yanwu , Belgorosky Alicia , Weiss Michael A. 
Published: May 2021

AbstractObjectiveTo describe the clinical, histopathological and molecular features of a novel inheritedSRYallele (p.Met64Val; consensus box position 9) observed within an extensive pedigree: two 46, XY sisters with primary amenorrhea (16 and 14 years of age; probands P1 and P2), their normal father and brother, and an affected paternal XY grandaunt.Design, Setting, Participants and Outcome MeasurementsFollowing DNA sequencing to identify the SRY mutation, hormonal studies of the probands and histopathological examination of their gonads were performed. Functional consequences of p.Met64Val (and other mutations at this site) were also investigated.ResultsBreast development in P1 and P2 was Tanner II and IV, respectively. Müllerian structures and gonads resembling ovaries were found in each sister. Histopathology revealed gonadal dysgenesis, gonadablastoma and dysgerminoma. AMH/MIS, P450 SCC, and P450 aromatase were expressed in gonadoblastoma tissues. Genomic sequencing revealed no candidate mutations in other genes related to sexual differentiation. Variant p.Met64Val impairedSox9transcriptional activation associated with attenuated occupancy of the testis-specific enhancersEnh13andTESCO. Biophysical studies indicated that the mutant HMG box retains specific DNA binding and DNA bending but with accelerated rate of protein-DNA dissociation.ConclusionThe partial biological activity of p.Met64Val SRY, maintained at the threshold of SRY function, rationalizes opposing paternal and proband phenotypes (the “the father-daughter paradox”). Steroidal biosynthesis by gonadoblastoma may delay genetic diagnosis and recognition of gonadal tumors. Quantitative assessment of inherited SRY alleles highlights the tenuous transcriptional threshold of developmental decision-making in the bipotential gonadal ridge.
The Effect of Minnelide against SARS-CoV-2 in a Murine Model
Authors: Caballero Van Dyke Marley C. , Mead Heather L. , Bryant Mitchell , Laux Klaire L. , Kollath Daniel R. , Coyne Vanessa K. , Miller Karis J. , Stone Nathan E. , Jaramillo Sierra A. , Keim Paul , Milikowski Clara , Gupta Vineet K. , Vickers Selwyn M. , Saluja Ashok K. , Velagapudi Mohana R. , Barker Bridget M. 
Published: May 2021

AbstractSevere acute respiratory syndrome coronavirus 2, SARS-CoV-2, is the causative agent of coronavirus disease 2019, COVID-19, and the current COVID-19 pandemic. Even as more vaccine candidates are released, more treatment options are critically needed. Here, we investigated the use of Minnelide, a water soluble pro-drug with anti-inflammatory properties, for the treatment of COVID-19. To do this, k18-hACE2 mice were infected with SARS-CoV-2 or given PBS control intranasally. The next day mice were either treated daily with low dose (0.0025mg/day) or high dose Minnelide (0.005mg/day), or given vehicle control intraperitoneal. Mice were weighed daily, and sacrificed at day 6 and 10 post-infection to analyze viral burden, cytokine response, and pathology. We observed a reduction in viral load in the lungs of Minnelide-treated mice infected with SARS-CoV-2 at day 10 post-infection compared to day 6 post-infection. All SARS-CoV-2 infected non-treated mice were moribund six days post-infection while treatment with Minnelide extended survival for both low (60% survival) and high (100% survival) dose treated mice ten days post-infection. Interestingly, cytokine analysis demonstrated a significant reduction in IL-6 (lung and heart) and D-dimer (serum) in high dose treated SARS-CoV-2 infected mice compared to mice infected with SARS-CoV-2 alone at day 6 post-infection. Additionally, histology analysis revealed that Minnelide treatment significantly improved lung pathology ten days post-infection with SARS-CoV-2 with all the mice exhibiting normal lung tissue with thin alveolar septa and no inflammatory cells. Overall, our study exhibits potential for the use of Minnelide to improve survival in COVID-19 patients.
Optimizing network neuroscience computation of individual differences in human spontaneous brain activity for test-retest reliability
Authors: Jiang Chao , He Ye , Betzel Richard F. , Wang Yin-Shan , Xing Xiu-Xia , Zuo Xi-Nian 
Published: May 2021

ABSTRACTA rapidly emerging application of network neuroscience in neuroimaging studies has provided useful tools to understand individual differences in intrinsic brain function by mapping spontaneous brain activity, namely intrinsic functional network neuroscience (ifNN). However, the variability of methodologies applied across the ifNN studies - with respect to node definition, edge construction, and graph measurements-makes it difficult to directly compare findings and also challenging for end users to select the optimal strategies for mapping individual differences in brain networks. Here, we aim to provide a benchmark for best ifNN practices by systematically comparing the measurement reliability of individual differences under different ifNN analytical strategies using the test-retest design of the Human Connectome Project. The results uncovered four essential principles to guide ifNN studies: 1) use a whole brain parcellation to define network nodes, including subcortical and cerebellar regions, 2) construct functional networks using spontaneous brain activity in multiple slow bands, 3) optimize topological economy of networks at individual level, 4) characterise information flow with specific metrics of integration and segregation. We built an interactive online resource of reliability assessments for future ifNN (ibraindata.com/research/ifNN).AUTHOR SUMMARYIt is an essential mission for neuroscience to understand the individual differences in brain function. Graph or network theory offer novel methods of network neuroscience to address such a challenge. This article documents optimal strategies on the test-retest reliability of measuring individual differences in intrinsic brain networks of spontaneous activity. The analytical pipelines are identified to optimize for highly reliable, individualized network measurements. These pipelines optimize network metrics for high inter-individual variances and low inner-individual variances by defining network nodes with whole-brain parcellations, deriving the connectivity with spontaneous high-frequency slow-band oscillations, constructing brain graphs with topology-based methods for edge filtering, and favoring multi-level or multi-modal metrics. These psychometric findings are critical for translating the functional network neuroscience into clinical or other personalized practices requiring neuroimaging markers.
Critical point equation on almost f-cosymplectic manifolds
Authors: Kumara H. Aruna , Venkatesha V. , Naik Devaraja Mallesha 
Published: May 2021

PurposeBesse first conjectured that the solution of the critical point equation (CPE) must be Einstein. The CPE conjecture on some other types of Riemannian manifolds, for instance, odd-dimensional Riemannian manifolds has considered by many geometers. Hence, it deserves special attention to consider the CPE on a certain class of almost contact metric manifolds. In this direction, the authors considered CPE on almost f-cosymplectic manifolds.Design/methodology/approachThe paper opted the tensor calculus on manifolds to find the solution of the CPE.FindingsIn this paper, in particular, the authors obtained that a connected f-cosymplectic manifold satisfying CPE with \lambda=\tilde{f} is Einstein. Next, the authors find that a three dimensional almost f-cosymplectic manifold satisfying the CPE is either Einstein or its scalar curvature vanishes identically if its Ricci tensor is pseudo anti‐commuting.Originality/valueThe paper proved that the CPE conjecture is true for almost f-cosymplectic manifolds.
Management and maintenance of research data by researchers in Zimbabwe
Authors: Chigwada Josiline Phiri 
Published: May 2021

Purpose
The concept of research data management (RDM) is new in Zimbabwe and other developing countries. Research institutions are developing research data repositories and promoting the archiving of research data. As a way of creating awareness to researchers on RDM, the purpose of this paper is to determine how researchers are managing their research data and whether they are aware of the developments that are taking place in RDM.

Design/methodology/approach
A survey using a mixed method approach was done and an online questionnaire was administered to 100 researchers in thirty research institutions in Zimbabwe. Purposive sampling was done by choosing participants from the authors of articles published in journals indexed by Google Scholar, Scopus and Web of Science. Interviews were done with five top researchers. The data was analysed using NVIVO. The results were presented thematically. The questionnaire was distributed using the research offices of the selected 30 research institutions. There was a 75% response rate.

Findings
The findings indicated that all the researchers are aware of the traditional way of managing research data. A total of 70% of the respondents are not aware of the current trends in RDM services, as they are keeping their data on machines and external hard drives, while 97.3% perceive RDM services as useful, as it is now a requirement when applying for research grants. Librarians have a bigger role to play in creating awareness on RDM among researchers and hosting the data repositories for archiving research data.

Practical implications
Research institutions can invest in research data services and develop data repositories. Librarians will participate in educating researchers to come up with data management plans before they embark on a research project. This study also helps to showcase the strategies that can be used in awareness creation campaigns. The findings can also be used in teaching RDM in library schools and influence public policy both at institutional and national level.

Social implications
This study will assist in building capacity among stakeholders about RDM. Based on the findings, research institutions should prioritise research data services to develop skills and knowledge among librarians and researchers.

Originality/value
Few researches on RDM practices in Zimbabwe were done previously. Most of the papers that were published document the perception of librarians towards RDM, but this study focused mainly on researchers’ awareness and perception. The subject is still new and people are beginning to research on it and create awareness amongst the stakeholders in Zimbabwe.
A bibliometric analysis of CSR in the banking industry: a decade study based on Scopus scientific mapping
Authors: Zainuldin Mohd Haniff , Lui Tze Kiat 
Published: May 2021

PurposeThis study bibliometrically describes and depicts the intellectual structure and knowledge progress of CSR studies in the banking industry.Design/methodology/approachBibliometric analysis is used to quantitatively examine the bibliographic data that gathered from Scopus database. The evaluative and relational techniques are employed to produce the findings and mappings for research themes, impact and directions, as well as collaboration trends. A topical classification is also included to review the results of different types of analysis.FindingsThis study discusses how the CSR literature in the banking industry has evolved between 2009 and 2019. The publications increase significantly from 2015 to 2019 and the top journals, authors, affiliations and countries are identified. Stakeholder, disclosure, financial performance, Islamic banks, corporate governance and international banks are among the popular research and collaboration trends found in the extant literature. Reflecting on the arguments in the previous literature, several key research gaps and further suggestions are acknowledged for future studies.Research limitations/implicationsThe bibliographic data used in this study bounds to Scopus database and the methodology itself suffers a few limitations, which integration of other methodologies will be worthwhile to unearth the field beyond the current discovery.Practical implicationsThis study is beneficial to potential researchers, scientific journal editors, and bankers to understand the current research progression and evolution within CSR field in the banking sector.Originality/valueCompared to the existing bibliometric literature, this study is among the pioneer wide-ranging bibliometrics study covering co-word, citation, bibliographic coupling, co-authorship and co-citation for CSR research in the banking sector.
Strategic priorities and competitiveness of businesses operating in different entrepreneurial ecosystems: a benefit of the doubt (BOD) analysis
Authors: Lafuente Esteban , Alonso-Ubieta Suyen , Leiva Juan Carlos , Mora-Esquivel Ronald 
Published: May 2021

PurposeThis study evaluates the relationship between the entrepreneurial ecosystem and business competitiveness in four different contexts (i.e. France, Spain, Hungary and Costa Rica).Design/methodology/approachThe study uses a sample of 348 manufacturing and knowledge-intensive business service firms operating in four countries with different entrepreneurial ecosystems (France, Spain, Costa Rica and Hungary) for 2019. Firm competitiveness is computed via the “benefit-of-the-doubt” (BOD) method, and a multilevel model is employed to assess the connection between the entrepreneurial ecosystem and firm competitiveness.FindingsThe results of the multilevel model indicate that the entrepreneurial ecosystem is related to firm competitiveness, while the BOD results suggest that firms operating in settings with a more consolidated entrepreneurial ecosystem are better able to realize the outcomes of strategic choices linked to the exploitation of key resources and capabilities. Country-specific results suggest that “human capital” is the most relevant competitive pillar prioritized by all sampled businesses.Originality/valueThe proposed analysis of the connection between the entrepreneurial ecosystem and business competitiveness in different contexts contributes to the development of the entrepreneurial ecosystem frame by offering insights into how the properties of the entrepreneurial ecosystem (i.e. interactions among individuals, organizations and institutions) can produce economically meaningful effects on business performance.
Usability and responsiveness of artificial intelligence chatbot on online customer experience in e-retailing
Authors: Chen Ja-Shen , Le Tran-Thien-Y , Florence Devina 
Published: May 2021

PurposeThe rapid evolution in artificial intelligence (AI) has redefined the customer experience and created huge opportunities for companies to interact with customers using chatbots. This study explores the role of AI chatbots in influencing the online customer experience and customer satisfaction in e-retailing.Design/methodology/approachA research model based on the technology acceptance model and information system success model is proposed to describe the interrelationships among chatbot adoption, online customer experience and customer satisfaction. Personality is a moderator in the model. The authors used a quantitative approach to collect 425 useable online questionnaires and Statistical Product and Service Solutions (SPSS) and SmartPLS to analyze the measurement model and proposed hypotheses.FindingsThe usability of the chatbot had a positive influence on extrinsic values of customer experience, whereas the responsiveness of the chatbot had a positive impact on intrinsic values of customer experience. Furthermore, online customer experience had a positive relationship with customer satisfaction, and personality influenced the relationship between the usability of the chatbot and extrinsic values of customer experience.Originality/valueThis research extends understanding of the online customer experience with chatbots in e-retailing and provides empirical evidence by showing that extrinsic and intrinsic values of online customer experience are enhanced by chatbot adoption.
Lubrication performance analysis of multi-groove sleeve bearing considering journal misalignment
Authors: Wang Lili , He Mengxue , Wang Min , Wei Yuliang 
Published: May 2021

Purpose
Under the influence of loading, manufacturing, installation and other factors, the axis of sleeve bearing and journal will not be aligned, which will have a great impact on running stability and life of bearing. The existence of oil groove can effectively improve the life of sleeve bearing and working efficiency. The lubrication performance of two and three grooves sleeve bearing considering journal misalignment is analyzed.

Design/methodology/approach
To solve the difference of discontinuous position of oil film thickness, it is necessary to use the flow balance relationship in the finite control space, and oil film thickness equation of multi-groove sleeve bearing considering journal misalignment is gained.

Findings
The friction and bearing capacity of journal bearing with oil groove increase with the increase of journal inclination angle. At the same journal inclination angle, the bearing capacity of two-axial groove journal bearing is larger than that of three-axial groove journal bearing, but the friction of two-axial groove journal bearing shows the trend of the first bigger and then smaller than that of three-axial groove journal bearing.

Originality/value
The research has great significance to optimize bearing lubrication performance and increase bearing working life.
Developing a novel index to evaluate labour chapters in trade agreements: Canada’s ambition–enforceability compromise
Authors: Williams Hanna , Lilly Meredith B. 
Published: May 2021

Purpose
Lack of progress advancing labour provisions in multilateral trade instruments has led some countries to develop their own labour chapters in bilateral and plurilateral trade agreements. This study aims to track the evolution of 25 years of labour chapters in Canadian trade agreements.

Design/methodology/approach
Modelled on Hoekman (1995), the authors present a novel index using the International Labour Organization’s (ILO) core labour standards to compare and evaluate ambition and enforcement in Canada’s labour chapters.

Findings
The quality of Canada’s labour chapters has steadily improved from 1994 to 2020, with scores rising from 46 to 91 out of 100. In addition, Canada has used its negotiating leverage to encourage partners with weak labour regimes to make improvements. Yet, the highest quality chapters were achieved with trade partners similar to Canada, and those chapters have not pushed either party to improve their own domestic labour regimes. The authors discuss the limits of the ILO standards for addressing contemporary debates about labour and trade.

Originality/value
The authors’ assessment provides the first empirical evidence to demonstrate that Canada’s labour chapters have evolved over time, and that the origins of this evolution predate the Liberal government’s progressive trade agenda by several decades. The authors also suggest that Canada’s “middle road” compromise on ambition versus enforceability may increase the relevance of the index for research on other middle powers and potentially countries in the global south.
Justice and development: the transnational bride trafficking from Vietnam to China
Authors: Nguyen Hung 
Published: May 2021

Purpose
This paper aims to provide an overview of transnational bride trafficking from Vietnam to China, enriching the human trafficking literature with the Vietnamese perspective. It proposes to analyze this bride trade in the developmental context and outline how the supplies and demands for brides root in socio-economical-legal forces such as poverty, lack of law enforcement and culture. This study also brings to attention the involvement of organized crime and collusion of government officials as the main drivers of the trafficking activities.

Design/methodology/approach
This paper opts for an analytical study using published data, including newspaper reports, previous research studies and public records. The data were complemented by the analysis of the trafficking victim’s stories, descriptions of trafficking activities, copies of statistics and the examination of the legal framework that concerns human trafficking in China and Vietnam.

Findings
This paper provides empirical insights into how transnational bride trafficking is brought about. It suggests that while the vulnerability to trafficking stems primarily from developmental forces, the most crucial element that makes this transnational bride trafficking possible is the involvement of organized crime.

Research limitations/implications
Because of the chosen research approach, this paper lacks originality in data, and some data might not be up-to-date because of the lack of sufficient interest.

Practical implications
This paper includes implications for developing a more nuanced understanding of transnational bride trafficking and the development of new policies that could remedy the issue.

Originality/value
Despite the fact that Vietnam is among countries most affected by human trafficking, there are only a few studies from the Vietnamese perspective. This paper fulfills the need to enrich the debate by providing an informative work on bride trafficking in Vietnam.
Properties of quenched and self-tempered reinforcing steel subjected to high temperature and different cooling conditions
Authors: Hager Izabela , Kańka Stanisław , Maślak Mariusz 
Published: May 2021

Purpose
The study presents test results concerning the impact of high temperature and different cooling conditions on the mechanical properties of quenched and self-tempered reinforcing steel. The purpose of this paper is to clarify the extent of the history of the material’s temperature development profile, the course and the intensity of fire exposure and how cooling conditions determines its properties.

Design/methodology/approach
Each specimen series was heated to the temperatures of T = 200°C, 400°C, 600°C, 700°C, 800°C and 1,000 °C. The specimens were either slowly cooled down or subjected to rapid cooling with water quenching, which can be encountered during a firefighting operation. Additionally, stress–strain relationships, microhardness and structural observations were also performed.

Findings
The results of the presented experiments have shown that the steel bars previously heated in fire conditions were very sensitive to the cooling intensity. The test results from the steel specimens – that were heated and quenched with water – demonstrate an increase in tensile strength but a significant reduction in material plasticity.

Originality/value
The presented piece of work provides a contribution for fire safety engineering giving insight into the fire behaviour of reinforcing steel under fire conditions and subjected to rapid or slow cooling. This study has shown the threats arising from thermally induced changes in steel microstructure because of high-temperature exposure. It should also be noted that structure changes may have a local character and refer to steel rebars that are exposed because of fire spalling of concrete cover.