bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma
Authors: Sheth Siddharth , Farquhar Douglas R. , Schrank Travis P. , Stepp Wesley , Mazul Angela , Hayward Michele , Lenze Nicholas , Little Paul , Jo Heejoon , Major M. Ben , Chera Bhishamjit S. , Zevallos Jose P. , Hayes D. Neil 
Published: June 2021

AbstractObjectivesPatients with laryngeal squamous cell carcinoma (LSCC) often fail radiation therapy (RT), when received as monotherapy or in combination with other treatment modalities. Mechanisms for RT failure are poorly understood. We hypothesized that tumors failing RT would have increased rates of somatic mutations in genes associated with radiation resistance, particularly in genes associated with the NFE2L2 oxidative stress pathway. Using targeted exome sequencing on pretreated LSCC tumors, we retrospectively compared somatic mutation profile with clinical data and response to treatment.MethodsTumors were classified as either radiation‐resistant (RR) or radiation‐sensitive (RS). RR was defined as persistent or recurrent disease within 2 years of receiving full‐dose RT. Early stage (ES) LSCC was defined as Stage I or II tumors without lymph node involvement. Eight genes associated with radiation resistance were prioritized for analysis. RT‐qPCR was performed on five NFE2L2 pathway genes.ResultsTwenty LSCC tumors were included and classified as either RR (n = 8) or RS (n = 12). No differences in individual rates of somatic mutations by genes associated with radiation resistance were identified. Higher rates of total mutational burden (TMB) and increased alterations associated with the NFE2L2 pathway was observed in RR vs RS tumors (P < .05). In an analysis of only ES‐LSCC patients (RR, n = 3 and RS, n = 3), RR tumors had increased NFE2L2 somatic pathway mutations (P = .014) and increased NQO1 mRNA expression (P = .05).ConclusionIncreased TMB and NFE2L2 pathway alterations were associated with radiation resistance in LSCC. NQO1 mRNA expression may serve as a biomarker for RT response in ES‐LSCC.Level of Evidence: II1.
Donor Morbidity Is Equivalent Between Right and Left Hepatectomy for Living Liver Donation: A Meta‐Analysis
Authors: Vargas Paola A. , McCracken Emily K.E. , Mallawaarachchi Indika , Ratcliffe Sarah J. , Argo Curtis , Pelletier Shawn , Zaydfudim Victor M. , Oberholzer Jose , Goldaracena Nicolas 
Published: June 2021

Maximizing liver graft volume benefits the living donor liver recipient. Whether maximizing graft volume negatively impacts living donor recovery and outcomes remains controversial. Patient randomization between right and left hepatectomy has not been possible due to anatomic constraints; however, a number of published, nonrandomized observational studies summarize donor outcomes between 2 anatomic living donor hepatectomies. This meta‐analysis compares donor‐specific outcomes after right versus left living donor hepatectomy. Systematic searches were performed via PubMed, Cochrane, ResearchGate, and Google Scholar databases to identify relevant studies between January 2005 and November 2019. The primary outcomes compared overall morbidity and incidence of severe complications (Clavien‐Dindo >III) between right and left hepatectomy in donors after liver donation. Random effects meta‐analysis was performed to derive summary risk estimates of outcomes. A total of 33 studies (3 prospective and 30 retrospective cohort) were used to identify 7649 pooled patients (5993 right hepatectomy and 1027 left hepatectomy). Proportion of donors who developed postoperative complications did not significantly differ after right hepatectomy (0.33; 95% confidence interval [CI], 0.27‐0.40) and left hepatectomy (0.23; 95% CI, 0.17‐0.29; P = 0.19). The overall risk ratio (RR) did not differ between right and left hepatectomy (RR, 1.16; 95% CI, 0.83‐1.63; P = 0.36). The relative risk for a donor to develop severe complications showed no differences by hepatectomy side (Incidence rate ratio, 0.97; 95% CI, 0.67‐1.40; P = 0.86). There is no evidence that the overall morbidity differs between right and left lobe donors. Publication bias reflects institutional and surgeon variation. A prospective, standardized, multi‐institutional study would help quantify the burden of donor complications after liver donation.
How do utilitarian versus hedonic products influence choice preferences: Mediating effect of social comparison
Authors: Shao Aiping , Li Hong 
Published: June 2021

AbstractThe present research explores how product type influences the trade‐off between relative and absolute best choice. We measure consumers' choice preferences and willingness to pay in five studies by manipulating different utilitarian versus hedonic products or different utilitarian versus hedonic goals of the same product. The results demonstrate that consumers prefer the absolute best choice for hedonic products and the relative best choice for utilitarian products (Studies 1a and 1b). When choosing a hedonic product, consumers are willing to pay significantly more for absolute than relative best choice. However, when choosing a utilitarian product, consumers are willing to pay more for the relative than absolute best choice, but the differences are not significant (Studies 2 and 3). Social comparison mediates the relationship between product type and choice preference. Specifically, compared to hedonic products, social comparison increases the relative best choice preference of utilitarian products (Study 4). Moreover, rivals moderate the effect of product type on choice preference (Study 5). The theoretical implication includes demonstrating the comparative advantage of product type on choice preference and interpreting the underlying mechanisms using social comparison. The findings also have important practical implications for utilitarian and hedonic consumption.
Methodological considerations on the means‐end chain analysis revisited
Authors: Kilwinger Fleur B. M. , van Dam Ynte K. 
Published: June 2021

AbstractMeans‐end chain analysis has been applied in a wide range of disciplines to understand consumer behavior. Despite its widespread acceptance there is no standardized method to analyze data. The effects of different analyses on the results are largely unknown. This paper makes a contribution to the methodological debate by comparing different ways to analyze means‐end chain data. We find that (1) a construct that is not mentioned can still be important to a respondent; (2) coding constructs at the same basic level or condensing constructs at a superordinate level lead to different results and both an increase and decrease of information; (3) aggregating data can be based on different algorithms which influences the results. Among available software packages there is no consistency in the used algorithm; (4) before applying means‐end chain analysis in a new research area the validity of assumptions underlying the research model should be evaluated. We conclude there is no universal “best way” to means‐end chain analysis, the most suitable approach depends on the research question. Research concerning how products are evaluated can best apply number‐of‐respondents‐based aggregation and low levels of condensation. Research concerning why products are valued can best apply frequency‐of‐responses‐based aggregation and high levels of condensation.
Banks CSR‐fit, customers' quality of life, and cross‐buying: A joint moderation model
Authors: Ogunmokun Oluwatobi A. , Timur Seldjan , Bayighomog Steven W. , Ikhide Juliet E. 
Published: June 2021

AbstractThe purpose of the current study is first to investigate attitudinal loyalty as a mediator of the relationship between corporate social responsibility (CSR)‐fit and cross‐buying, before examining the interaction of CSR‐fit, CSR support, and quality of life in predicting cross‐buying through attitudinal loyalty. In total, 821 bank customers provided data for this study by filling online and in‐person surveys. The results from data analysis reveal that customers' perceived CSR‐fit relationship with cross‐buying behavior is mediated by their attitudinal loyalty toward their bank. Moreover, the conditional process analysis indicated that while CSR support strengthened the relationship of CSR‐fit and attitudinal loyalty, quality of life weakened this relationship. Specifically, in response to their banks' CSR‐fit, respondents with high CSR support and perceived low quality of life were the most likely to be loyal and engage in cross‐buying behaviors. The least, however, are those with low support and perceived high quality of life. This study enlightens our understanding of the intricate relationship between CSR‐fit perceptions and loyalty attitudes and behaviors. It further proposes a complex model investigating the psychological contingencies of the relationship and its marketing implication in the financial sector.
Constructing Stable and Porous Covalent Organic Frameworks for Efficient Iodine Vapor Capture
Authors: Zhai Lipeng , Han Diandian , Dong Jinhuan , Jiang Wenqian , Nie Riming , Yang Xiubei , Luo Xiaolong , Li Zhongping 
Published: June 2021

AbstractCovalent organic frameworks (COF) with periodic porous structures and tunable functionalities are a new class of crystalline polymers connected via strong covalent bonds. Constructing COF materials with high stability and porosity is attracting and essential for COFs’ further functional exploration. In this work, two new covalent organic frameworks (TTA‐TMTA‐COF and TTA‐FMTA‐COF) with high surface area, large pore volume, and excellent chemical stability toward harsh conditions are designed and synthesized by integrating the methoxy functional groups into the networks. Both two COFs are further employed for iodine removal since radioactive iodine in nuclear waste has seriously threatened the natural environment and human health. TTA‐TMTA‐COF and TTA‐FMTA‐COF can capture 3.21 and 5.07 g g−1 iodine, respectively. Notably, the iodine capture capacity for iodine of TTA‐FMTA‐COF does not show any decline after being recycled five times. These results demonstrate both COFs possess ultrahigh capacity and excellent recyclability.
CircSPAG16 suppresses cadmium‐induced transformation of human bronchial epithelial cells by decoying PIP5K1α to inactivate Akt
Authors: Wang Qin , Pan Shuya , Jiang Qi , Li Luyao , Tu Wei , Zhang Qian , Zhou Xue 
Published: June 2021

AbstractCircular RNAs (circRNAs) have been implicated to have important regulatory functions in chemical carcinogenesis via sponging microRNAs to regulate gene expression. Our study revealed a novel mechanism of circRNA in cadmium carcinogenesis through directly binding with protein. Here, we used cadmium‐transformed human bronchial epithelial BEAS‐2B cells to study the involvement and mechanism of circRNA in lung carcinogenesis caused by cadmium. By high‐throughput sequencing, circSPAG16 was identified to be the most significantly downregulated circRNA in cadmium‐transformed cells. CircSPAG16 was downregulated at Week 8, 12, 16, and 20 during cadmium‐induced cell transformation. In addition, circSPAG16 overexpression prevented cadmium‐induced transformation of BEAS‐2B cells. Mechanistically, circSPAG16 inhibited the function of phosphatidylinositol 4‐phosphate 5‐kinase type‐1 α (PIP5K1α) by binding with it. We demonstrated that PIP5K1α acted as an oncogene to activate Akt and promoted cancer hallmarks including proliferation, migration, invasion, and anchorage‐independent growth in cadmium‐transformed cells. CircSPAG16 overexpression inactivates PIP5K1α/Akt signaling in the transformed cells. Furthermore, PIP5K1α overexpression significantly rescued the inhibitory effects of circSPAG16 overexpression on pAkt and cancer hallmarks in cadmium‐transformed cells. Collectively, our results revealed that circSPAG16 could prevent cadmium‐induced transformation through binding with PIP5K1α to inactivate Akt. These results provide a novel regulatory mechanism of circRNA into carcinogenesis induced by cadmium.
Radiofrequency‐induced heating of broken and abandoned implant leads during magnetic resonance examinations
Authors: Yao Aiping , Goren Tolga , Samaras Theodoros , Kuster Niels , Kainz Wolfgang 
Published: June 2021

PurposeThe risks of RF‐induced heating of active implantable medical device (AIMD) leads during MR examinations must be well understood and realistically assessed. In this study, we evaluate the potential additional risks of broken and abandoned (cut) leads.MethodsFirst, we defined a generic AIMD with a metallic implantable pulse generator (IPG) and a 100‐cm long lead containing 1 or 2 wires. Next, we numerically estimated the deposited in vitro lead‐tip power for an intact lead, as well as with wire breaks placed at 10 cm intervals. We studied the effect of the break size (wire gap width), as well as the presence of an intact wire parallel to the broken wire, and experimentally validated the numeric results for the configurations with maximum deposited in vitro lead‐tip power. Finally, we performed a Tier 3 assessment of the deposited in vivo lead‐tip power for the intact and broken lead in 4 high resolution virtual population anatomic models for over 54,000 MR examination scenarios.ResultsThe enhancement of the deposited lead‐tip power for the broken leads, compared to the intact lead, reached 30‐fold in isoelectric exposure, and 16‐fold in realistic clinical exposures. The presence of a nearby intact wire, or even a nearby broken wire, reduced this enhancement factor to <7‐fold over the intact lead.ConclusionBroken and abandoned leads can pose increased risk of RF‐induced lead‐tip heating to patients undergoing MR examinations. The potential enhancement of deposited in vivo lead‐tip power depends on location and type of the wire break, lead design, and clinical routing of the lead, and should be carefully considered when performing risk assessment for MR examinations and MR conditional labeling.
Open birdcage coil for head imaging at 7T
Authors: Nikulin Anton V. , Vignaud Alexandre , Avdievich Nikolai I. , Berrahou Djamel , de Rosny Julien , Ourir Abdelwaheb 
Published: June 2021

PurposeTo theoretically describe, design, and test the new geometry of the birdcage coil for 7 Tesla anatomical brain imaging, which includes a large window on top, without deliberately jeopardizing its homogeneity and efficiency. This opencage will not only improve patient comfort but also enable the volunteer to follow functional MRI stimuli. This design could also facilitate the tracking of patient compliance and enable better correction of the movement.MethodsVia the transfer matrix approach, a birdcage‐like coil with a nonperiodic distribution of rungs is constructed with optimized currents in the coil rungs. Subsequently, the coil is adjusted in full‐wave simulations. Then, the coil is assembled, fine‐tuned, and matched on the bench. Finally, these results are confirmed experimentally on a phantom and in vivo.ResultsIndeed, the computed isolation of −14.9 dB between the feeding ports of the coil and the symmetry of the circular polarized mode pattern transmit RF magnetic field () showed that the coil was properly optimized. An experimental assessment of the developed coil showed competitive transmit efficiency and coverage compared with the conventional birdcage coil of similar size.ConclusionThe proposed opencage coil can be designed and work without a dramatic drop of performance in terms of the field homogeneity, transmit efficiency (/), peak local specific absorption rate () and SAR efficiency (/).
A systematic review of utility‐based and disease‐specific quality of life measurement instruments for women with urinary incontinence
Authors: Wuytack Francesca , Moran Patrick , Daly Deirdre , Panda Sunita , Hannon Kathleen , Cusack Cinny , O'Donovan Maggie 
Published: June 2021

AbstractAimThis systematic review aims to identify disease‐specific and generic quality of life (QoL) outcome measurement instruments used in populations of women with urinary incontinence (UI) and to determine the most psychometrically robust and appropriate disease‐specific and generic tools for measuring the quality of life in this population.MethodsA systematic search was conducted of PubMed, Embase, SCIELO, and CINAHL databases for studies evaluating measurement properties of QoL instruments in women with UI. The methodological quality of studies and the quality of measurement properties were evaluated using the COnsensus‐based Standards for the selection of health status Measurement INtruments (COSMIN) checklist and quality criteria. Overall, evidence for measurement properties was graded using the modified grading of recommendations, assessment, development & evaluation approach.ResultsA total of 73 studies were included, and 27 specific and 6 generic instruments were identified. The Incontinence QoL questionnaire (IQoL) had the highest overall psychometric quality for English‐speaking populations and was the most widely translated tool. Evidence for generic QoL tools in this population is limited. Few studies evaluated measurement error or cross‐cultural validity.ConclusionThe IQoL is the most psychometrically robust disease‐specific tool for use in this population. More research is needed to determine the most psychometrically robust generic tool. Future studies should also evaluate measurement error and cross‐cultural validity as evidence for these properties is particularly lacking.
Pain and functionality improved when underlying neuromuscular dysfunction addressed in chronic pelvic pain patients
Authors: Natarajan Janaki , Ahmed Tayyaba , Patil Soha , Mamsaang Marjorie , Kapadia Rucha , Tailor Yogita , Shrikhande Allyson 
Published: June 2021

AbstractAimExamine the effects of treating underlying neuromuscular dysfunction in chronic pelvic pain (CPP) patients.MethodsA retrospective longitudinal study of 200 female and male patients with CPP was performed upon an Institutional Review Board (IRB) approval (IRB# 17‐0761). The outpatient protocol consisted of ultrasound‐guided trigger point injections to the pelvic floor musculature with peripheral nerve blocks once a week for 6 weeks in an outpatient setting. Pelvic pain and functionality were measured before and after treatment using the Visual Analogue Scale and the Functional Pelvic Pain Scale. Functionality categories assessed were intercourse, bladder, bowel, working, walking, running, lifting, and sleeping.ResultsPretreatment, mean VAS score was 6.44 (standard deviation [SD] = 2.50;p < 0.05, 95% confidence interval [CI] = 6.09–6.79). Posttreatment mean VAS score was 4.25 (SD = 2.63;p < 0.05, 95% CI = 3.88–4.61). The mean FPPS score before treatment was 10.77 (SD = 6.39;p < 0.05, 95% CI = 9.88–11.65). Posttreatment mean FPPS score was 7.42 (SD = 5.87;p < 0.05, 95% CI = 6.61–8.23). Analysis of subcategories within FPPS indicated statistically significant improvement in the categories of intercourse, working, and sleeping.ConclusionFindings show the treatment was efficient at decreasing pain in CPP patients. Results show promise for improving overall pelvic functionality, particularly within the categories of intercourse, sleeping, and working.
Age at surgery is not a prognostic factor for the AdVance‐XP male sling efficacy: A post‐hoc analysis of a prospective 7‐year multicentric study
Authors: Mumm Jan‐Niclas , Abrarova Benazir , Schütz Julius , Klehr Benedikt , Rodler Severin , Vilsmaier Theresa , Gozzi Christian , Rehder Peter , May Florian , Homberg Roland , Gebhartl Peter , Stief Christian G. , Buchner Alexander , Bauer Ricarda M. 
Published: June 2021

AbstractObjectiveTo evaluate the factor age at the surgery on long‐term postoperative outcomes in patients with postprostatectomy incontinence (PPI) after AdVance XP transobturator male sling implantation.MethodsA total of 115 male patients with PPI, who had undergone AdVance XP sling implantation, were included. Patients had PPI with endoscopically confirmed good sphincteric‐contractility and a positive coaptive response. Kruskal–Wallis test with Dunn post‐hoc tests were used to analyze the postoperative outcome differences between the patient groups aged less than 66, 66–75, and over greater than 75 years. Outcome measures were the 24 h pad test, the number of daily pads used, the International Consultation on Incontinence Questionnaire short form (ICIQ‐SF), International Quality of Life Score (IQOL), Patient Global Impression of Improvement (PGI‐I), International Index of Erectile Function‐5 (IIEF‐5), International Prostate Symptom Score (IPSS), and Visual Analog Scale scores. Observation time points were 3, 6, 12, 24, 36, 48, 60, and 84 months after surgery.ResultsBetween the age groups, there was no difference in the success rate of the procedure (defined as 0 pads/24 h and less than 5 g in the 24‐h pad test) at any point in time. Subjective parameters measures using the ICIQ‐SF, PGI‐I, IQOL, and IPSS scores showed no differences between the two cohorts. Only erectile function (IIEF‐5 score) was lower in older patients in comparison to the cohort aged less than 66 years (p < 0.05 at 3, 6, 12, 24, 36, and 48 months).ConclusionsThe present study complements the European multicentre AdVance XP follow‐up study. Here, we show that age at surgery does not affect the objective success, subjective success, or the complication rate. Thus, we do not recommend factoring in chronological age into surgical selection criteria for the AdVance XP implantation.
Eternal love locked in an embrace and sealed with a ring: A Xianbei couple's joint burial in North Wei era, China (386–534 CE)
Authors: Zhang Quanchao , Hou Xiaogang , Yang Shiyu , Ruan Sunzifeng , Wang Anqi , Li Pengzhen , Sun Xiaofan , Zhu Hong , Zhang Qun , Wang Qian 
Published: June 2021

AbstractLove as an important part of human emotion has been depicted in literature, folklore, and art since ancient China. However, in archaeological settings, direct skeletal evidence for love is rare. A joint burial from North Wei Dynasty (386–534 CE) was reported, in which skeletons of an adult male and an adult female were found placed in loving embrace posture with a ring in situ on the left ring finger of the female, displaying the desire for eternal love of the couple, and the respect to their love by people who buried them as well. It is likely that the wife sacrificed herself to be buried with her dead husband, though other scenarios could not be ruled out. The free expression and active pursuit of love in Chinese culture became prominent during the first millennium. This funerary practice might have been influenced by the customs from the Western Regions and beyond through the Silk Roads and the Sinicization and assimilation of the Xianbei people. This discovery is a unique display of human emotion of love in a burial, offering a rare glimpse people's views towards love, life, death, and afterlife in northern China during a time of intense cultural and ethnic exchange.