bluuebunny/crossref_metadata_2025_split huggingface dataset:
National disparities in colorectal cancer screening in patients with comorbid conditions: an analysis of the Behavioral Risk Factor Surveillance System
Authors: Greiner Benjamin , Gandhi Ronak , Abrol Robinder , Patel Milee , Hartwell Micah 
Published: April 2021

Abstract

Context
Each year, approximately 53,200 people die in the U.S. from colorectal cancer (CRC), indicating a need to increase screening efforts. Some studies have suggested mammography use is higher in patients with comorbid conditions, a reflection of increased follow up. Another study found that patients with obesity were less likely to be screened for CRC than nonobese patients. However, no study has assessed the impact of multiple comorbidities on CRC screening.

Objectives
To analyze CRC screening rates in patients with comorbidities compared with healthy patients, and to assess whether the number of comorbid diagnoses impacted screening rates.

Methods
A cross sectional analysis of patients who received CRC screening was performed using the 2018 and 2019 Behavioral Risk Factor Surveillance System (BRFSS). Respondents were classified as having had CRC screening if they answered “yes” to either of the following: “Have you ever had a blood stool test?” or “Have you ever had a sigmoidoscopy/colonoscopy?” Respondents younger than age 50 were excluded. A weighted multivariate logistic regression model was constructed to determine adjusted risk ratios (ARR). Confidence intervals (CI) were reported at 95%.

Results
We identified 279,784 respondents who met inclusion criteria. Of those, 79.7% (sample n=222,879; population N=46,304,360) of respondents had received CRC screening. Patients with diabetes, hypertension, skin cancer, chronic obstructive pulmonary disease (COPD), arthritis, depression, and chronic kidney disease were significantly more likely to be screened than those without comorbidities. There was no statistically significant difference in screening rates between patients with and without cardiovascular disease. Compared with patients with zero comorbidities, those with one were significantly more likely to receive screening (ARR, 1.11; CI, 1.09–1.12) as were those with two to four (ARR, 1.2; CI, 1.18–1.22). Patients with five or more comorbidities were significantly less likely to be screened than those with two to four (ARR, 1.12; CI, 1.1–1.14).

Conclusions
Patients with one or more comorbidities were more likely to be screened than those without comorbidities, but those with five or more conditions were less likely to be screened than patients with two to four conditions. This indicates that physicians may be more fatigued and less likely to recommend CRC screening to patients with many comorbidities compared with patients diagnosed with only a few conditions. The results of this study add to the literature by identifying an interaction between the number of comorbidities and likelihood of being screened for CRC.
Poetik einer neuen Metamorphose: zu Róža Domašcynas Dichtung
Authors: Koschmal Walter 
Published: April 2021

Summary
The paper characterizes the poetics of the Sorbian poet Róža Domašcyna (*1951). Domašcyna creates diverse methods of metamorphosis in her numerous lyrical works. Different concepts of metamorphosis from Ovid to Goethe as well as concepts of Chinese philosophy are discussed. The novelty of Domašcyna’s concept lies in her language, particularly in the mutation of sound and transformation of all reality. The paper uses “parkfiguren,” a speech composition created together with the composer Harald Muenz, as an example to analyze Domašcyna’s new metamorphosis. It is precisely her extremely uncertain take on metamorphosis that makes this poetic language the language of our present.
Chemical composition of Satureja spicigera essential oil and its insecticidal effectiveness on Halyomorpha halys nymphs and adults
Authors: Gokturk Temel 
Published: April 2021

Abstract
The brown marmorated stink bug, Halyomorpha halys (Stål 1855) (Hemiptera: Pentatomidae) is an invasive and economically important agricultural and ornamental insect pest nowadays established in many countries. There are numerous methods used for its control. Due to the increased risk of chemical contamination upon the application of synthetic insecticides to control harmful insects, essential oils are gaining increasing attention. In this research, the insecticidal effectiveness of Satureja spicigera (C. Koch) Boiss (Laminaceae) essential oil at 10, 15 and 20 μL/mL doses, and 24, 48, 72 and 96 h against five nymph instars and adults of H. halys was investigated. In addition, the chemical analysis of S. spicigera essential oil was done by GC-MS. The major components of the S. spicigera oil were carvacrol (32.14%), thymol (20.01%), ɣ-terpinene (17.05%), p-cymene (9.08%) and carvacrol methyl ether (5.70%). At the 96th h of the study, the essential oil caused a mortality rate of between 20.1 and 87.5%. The positive control (Nimbecidine®) had the highest mortality rates for nymphs (100%) and adults (90.3%). According to the LD50 and LD90 values, while the most toxic LD50 values were recorded as 0.63 and 4.66 μL/mL for the N1 instar and adults, the lowest LD90 values were 19.12 and 26.32 μL/mL for the N5 instar and adults, respectively. In conclusion, results showed that S. spicigera oil had a highly toxic effect against five nymph instars and adults of H. halys.
Umfrage zum Änderungsmanagement in der Produktion Status quo, industrielle Anwendung der Änderungsauswirkungsanalyse und Stand der Digitalisierung
Authors: Sippl Fabian , Schellhaas Lukas , Bauer Harald 
Published: April 2021

Abstract
Das zunehmend turbulente Umfeld produzierender Unternehmen erfordert die permanente Anpassung der Produktion an neue interne und externe Anforderungen. Daher ist ein effizientes Änderungsmanagement in der Produktion (MCM) ein Schlüsselfaktor zur Sicherung der langfristigen Wettbewerbsfähigkeit. Im Rahmen der in diesem Beitrag vorgestellten Studie wurden Mitarbeitende produzierender Unternehmen zum Status quo des MCM und zur Anwendung der Änderungsauswirkungsanalyse (ÄAA) befragt. Die Studie liefert Informationen bezüglich der aktuellen Bedeutung und der Digitalisierung des MCM sowie bestehender Hindernisse bei der Durchführung der ÄAA. Um die aktuellen Entwicklungen einordnen zu können, werden die Kernaussagen in Relation zu einer in der Vergangenheit durchgeführten Studie gesetzt.**
Presence of the Diffuse Idiopathic Skeletal Hyperostosis in Avinganya rural population (Lleida, Iberian Peninsula).
Authors: Fuentes-Sánchez Daniel , López-Onaindia Diego , Dinarès Rosa , Subirà M. Eulàlia 
Published: April 2021

Diffuse idiopathic skeletal hyperostosis (DISH) has largely been associated with high socioeconomic status rather than lower social status in paleopathological studies. This difference has been explained as a consequence of a high intake of fats and sedentary lifestyle that could be related to metabolic syndrome and obesity, associated risk factors in DISH by some clinical authors. This association is also known as the ‘monastic way of life’. In this work, we present a DISH case corresponding to a male individual exhumed from a civil burial site of the necropolis of the Trinitarian Monastery of Avinganya, in the North-East of Iberian Peninsula. In this case, DISH coexists with some evidences of occupational stress markers (back lesions and traumas) that indicate a non-sedentary lifestyle, despite the individuals overweight. Therefore, the present case of DISH seems to contradict the ‘monastic way of life’ association. The previous relationship can be explained as a bias in the sample analysed, where high status individuals have longer survival ratios, so more probabilities to develop DISH, because age is a proved risk factor. In this way, mechanical stress is proposed as another risk factor of DISH, which is more accurate to explain this case.
Role of Electrical Source Imaging in Pediatric Epilepsy and Pre-Surgical Evaluation
Authors: Thurairajah Arun 
Published: April 2021

Children with drug-resistant epilepsy undergo an extensive pre-surgical evaluation to determine the part of the brain thought to be the cause of seizures. The employment of non-invasive diagnostic imaging tools plays an important role in establishing surgical candidacy, preventing the need for invasive procedures. Electrical source imaging (ESI) has been explored as a modern alternative to traditional diagnostic techniques in pre-surgical workup. Through computational analysis of recorded electric potentials and individualized head scans, ESI provides a non-invasive method of obtaining more accurate localizations. However, its use within the clinical setting is limited. The following review looks to examine the literature surrounding ESI and advocates for its inclusion within the pre-surgical workup of children.
Breastfeeding, Physical Growth, and Cognitive Development
Authors: Wallenborn Jordyn T. , Levine Gillian A. , Carreira dos Santos Angélica , Grisi Sandra , Brentani Alexandra , Fink Günther 
Published: April 2021

BACKGROUND AND OBJECTIVES:
Breastfeeding is an evidence-based recommendation for all countries, but breastfeeding rates have been declining in many middle-income settings. One reason behind this decline is the perception that breastfeeding may not be necessary in modern urban settings, where clean water is available and alternative foods are abundant. We investigate the importance of breastfeeding for early childhood development in the modern urban context of São Paulo, Brazil.

METHODS:
In our study, we used data from the ongoing prospective Western Region Birth cohort in São Paulo, Brazil. Children were recruited at birth and managed for 3 years. Durations of exclusive and mixed breastfeeding were our primary independent variables. Our secondary independent variable was an indicator for compliance with World Health Organization (WHO) breastfeeding recommendations. Our primary outcomes of interest were indicators of children’s physical, cognitive, language, and social-emotional development at 3 years of age. Adjusted estimates and 95% confidence intervals were calculated by using linear and logistic regression.

RESULTS:
Complying with WHO recommendations to exclusively breastfeed for 6 months followed by complementary feeding until 2 years of age was associated with a 0.4-SD increase in overall child development (β: .38; confidence limit = 0.23 to 0.53), a 0.6-SD increase in height-for-age z score (β: .55; confidence limit = 0.31 to 0.79), and a 67% decrease in the odds of stunting (odds ratio = 0.33; 95% confidence interval = 0.20 to 0.54).

CONCLUSIONS:
Our results suggest that even in settings with easy access to complementary foods, complying with WHO breastfeeding recommendations is important for healthy physical growth and cognitive development.
Cognitive Behavioral Therapy for Autism Spectrum Disorders: A Systematic Review
Authors: Wang Xinyuan , Zhao Jinzhu , Huang Shan , Chen Shuling , Zhou Tuo , Li Qing , Luo Xiaoping , Hao Yan 
Published: April 2021

CONTEXT:
In several studies, authors have reported on cognitive behavioral therapy (CBT) for children and adolescents with autism spectrum disorders (ASDs), but inconsistent treatment effectiveness was revealed from these studies.

OBJECTIVE:
To evaluate the effectiveness of CBT on the symptoms of ASD and social-emotional problems in children or adolescents with ASD by using a meta-analytic approach.

DATA SOURCES:
Data sources included PubMed, Embase, and the Cochrane Library.

STUDY SELECTION:
We selected randomized controlled trials (RCTs) in which authors reported effectiveness of CBT on the symptoms of ASD and social-emotional problems in children or adolescents with ASD from database inception to May 2019.

DATA EXTRACTION:
For each study, 2 authors extracted data on the first author’s surname, publication year, country, sample size, mean age, CBT target, intervention, outcome measurement, follow-up duration, and investigated outcomes.

RESULTS:
Forty-five RCTs and 6 quasi RCTs of 2485 children and adolescents with ASDs were selected for the final meta-analysis. There was no significant difference between CBT and control for symptoms related to ASD based on self-reported outcomes (standard mean difference: −0.09; 95% confidence interval: −0.42 to 0.24; P = .593), whereas CBT significantly improved the symptoms related to ASD based on informant-reported outcomes, clinician-rated outcomes, and task-based outcomes. Moreover, the pooled standard mean differences indicated that CBT has no significant effect on symptoms of social-emotional problems based on self-reported outcomes.

LIMITATIONS:
The quality of included studies was low to modest, significant heterogeneity among the included studies for all investigated outcomes was detected, and publication bias was inevitable.

CONCLUSIONS:
These findings indicate that CBT may significantly improve the symptoms of ASD and social-emotional problems in children or adolescents with ASD.
¿Cómo y con quien nos comunicamos por medio de las TIC? Uso de internet en estudiantes y docentes universitarios del área de humanidades
Authors: Espinosa Pastora Moreno , González-Quiñones Fidel , Tarango Javier 
Published: April 2021

En esta investigación se analiza el uso de las Tecnologías de Información y Comunicación (TIC), en los docentes y estudiantes de seis carreras del área de humanidades en la Universidad Autónoma de Chihuahua. El objetivo principal fue establecer un perfil de los usuarios tomando en cuenta el tiempo que pasan conectados al internet, la temática abordada durante estas sesiones, los navegadores, buscadores y bases de datos utilizados y por último la forma y el tipo de personas con quien el usuario se comunica. La muestra analizada constituye un nicho en el cual todos los encuestados tienen contacto constante con las TIC y aun cuando existe una brecha importante en las variables sociodemográficas de estudiantes y docentes, se detectó que estas diferencias digitales entre ambos grupos son muy pequeñas.Con la información recabada se podrá reflexionar sobre cuáles son los retos para dar a las TIC un uso que permita sacar su máximo provecho en aras de incrementar la productividad de estudiantes y maestros. Fidel González-QuiñonesORCID: 0002-8404-0098Universidad Autónoma de Chihuahua Pastora Moreno EspinosaORCID: 0001-6494-130XUniversidad de Sevilla
Role of inflammation and iron exchange disorders in progression of liver cirrosis
Authors: Bulatova I. A. , Shchekotova A. P. , Paducheva S. V. 
Published: April 2021

Objective. To assess the role of the main pathogenetically significant molecules, including tumor necrosis factor alpha (TNF-) and transferrin, as an inflammatory protein, in the progression of chronic diffuse liver diseases (CDLD).
Material and methods. The study involved 86 patients with cirrhosis of the liver (LC) of viral, alcoholic and mixed etiology. Inflammatory parameters were studied, including tumor necrosis factor alpha (TNF-), indicators of iron metabolism, -fetoprotein (AFP), vasculoendothelial growth factor (VEGF), and functional liver biochemical tests. The control group consisted of 70 persons.
Results. It was revealed that the LC severity class is interrelated with the clinical manifestations of the disease, the severity of biochemical syndromes as well as a significant increase in the concentration of -globulins, CRP, the amount of TNF- up to 3.5 (2.64.7) pg/ ml (p 0.001) and ferritin up to 325.8 (209; 401) ng / ml (p 0.001) compared to the control group. An increase in TNF- and ferritin as inflammatory protein in LC confirms the growth of the activity of inflammation in the liver and correlates with other parameters involved in the pathogenesis of LC: with VEGF, as a marker of endothelial dysfunction, which is involved in the activation of fibrosis and neoangiogenesis, and AFP, reflecting regeneration processes in the liver.
Conclusions. The progression of liver damage in cirrhosis is based primarily on the secondary inflammation caused by portal hypertension with the entry of intestinal antigens and toxins into the central bloodstream. At the same time, the perverse circle of the development of the disease is closed.
O livro que [r]existe: a confluência de gêneros como signo da contemporaneidade em <i>Livro</i> de José Luiz Peixoto
Authors: Navas Diana , Tavares José Luiz Cordeiro Dias 
Published: April 2021

O presente estudo, que assume como corpus o romance Livro (2012), de José Luís Peixoto, almeja apresentar a confluência de gêneros que se observa na composição desta obra, evidenciando como seu hibridismo mantém estreito diálogo com o contexto contemporâneo em que se insere. Partindo de uma breve reflexão acerca das marcas da atual ficção contemporânea portuguesa – a confluência dos gêneros, a metaficção, a polifonia e a paródia – , apresentamos, a seguir, o romance de Peixoto, evidenciando como nele os gêneros literários e não-literários se fundem e se (con)fundem, promovendo a construção de um livro híbrido. Nessa obra, não apenas a poesia insere-se no romance, mas o ensaio e outros gêneros perpassam a narrativa, tornando o espaço romanesco plural e heterogêneo. Ao final, demonstramos como a confluência de gêneros neste romance está em consonância com o atual cenário contemporâneo, também marcado pela multiplicidade e heterogeneidade.
Patogenesis dan virulensi Burkholderia pseudomallei penyebab melioidosis dan Burkholderia cepacia sebagai patogen oportunis
Authors: Tjampakasari Conny Riana 
Published: April 2021

Diantara genus Burkholderia terdapat dua spesies yang menjadi perhatian dalam bidang kesehatan, yaitu B. pseudomallei dan B. cepacia. Kedua bakteri ini menyebabkan masalah klinis yang berbeda. Penyakit melioidosis kerap disebabkan oleh B.pseudomallei, sedangkan B. cepacia complex (Bcc) seringkali ditemukan pada pasien cystic fibrosis (CF). Burkholderia pseudomallei merupakan kelompok bakteri patogen intracellular Gram negatif, memiliki bentuk seperti peniti. Demikian pula B. cepacia merupakan kelompok bakteri Gram negatif basil, tidak dapat membentuk spora, bersifat aerobik, katalase dan oksidase positif, serta mempunyai flagel polar multitrik. Meskipun jalur patogenesis kedua bakteri ini sedikit berbeda, faktor virulensi yang dimiliki oleh kedua spesies ini hampir sama. B. pseudomallei memiliki kemampuan untuk menginfeksi berbagai jenis sel dan menghindari respon imun manusia. Bakteri ini masuk melalui kulit atau selaput lendir dan bereplikasi di sel epitel. Di dalam sel inang, bakteri bergerak dengan menginduksi polimerisasi aktin inang, mendesak dinding membran membentuk tonjolan yang meluas ke sel lain. Tonjolan ini menyebabkan sel tersebut bergabung, membentuk sel raksasa berinti (multinucleated giant cell /MNGC). MNGC akan membentuk plak sebagai tempat bagi bakteri untuk bereplikasi. Setelah memasuki saluran pernafasan pasien penderita CF, B. cepacia menempel pada permukaan sel mukosa ataupun sel epitel inang. Lapisan mukus yang menebal pada paru mendukung efikasi antimikrobia dan meningkatkan respon inflamasi. Kemampuan untuk melewati barier epitelial dan menemukan akses ke aliran darah hanya dimiliki oleh strain kelompok ini karena patogen lain yang ditemukan pada pasien CF tidak menyebabkan bakteremia. Faktor virulensi bertugas membantu proses invasi sel inang oleh bakteri patogen. Secara umum, kedua spesies ini memiliki jenis faktor virulensi yang sama, diantaranya adalah intracellular survival, quorum sensing, adherence factor, sistem sekresi, LPS dan EPS, biofilm, toksin dan resistensi antimikrobia.
Além do económico
Authors: Trindade Catarina Casimiro 
Published: April 2021

Neste artigo, discuto as definições atribuídas ao xitiki, conhecido como uma prática endógena de poupança e crédito rotativo bastante comum na cidade de Maputo, Moçambique. Partindo de uma discussão sobre as implicações de se traduzir a palavra xitiki por poupança, o objectivo deste artigo é mostrar como as definições e descrições existentes na bibliografia sobre este tipo de prática, não só em Moçambique mas um pouco por todo o mundo, são limitadoras e não dão conta dos significados articulados e das relações estabelecidas por estas práticas.
KEANEKARAGAMAN JENIS POHON PENYUSUN ARBORETUM KONSERVASI HUTAN HUJAN TROPIS PT ASMIN BARA BRONANG KABUPATEN KAPUAS KALIMANTAN TENGAH
Authors: Maimunah Siti , Mudzakir Hasan , Sopan Mohammad , Samek Jay H. 
Published: April 2021

The arboretum area is inside the concession area in Barunang Village, Kapuas Regency, Central Kalimantan, which is in the heath forest area towards the lowland forest. Arboretum area 28 ha with a elevation on 114 mdpl.The research methodology uses a modified version of the Biodiversity Assessment Tool originally developed by the High Conservation Values Resource Network (HCVRN) and the World Wildlife Fund (WWF). The method developed by USAID LESTARI and the University Consortium together with Michigan State University USA.The results showed that there were 29 arboretum tree compilers which were dominated by Myrtaceae family of 36 tree species, 32 species of Dipterocarpaceae and 20 species of Myristicaceae which were distributed in groups according to the topography and associated species associations. Species Richness 93; Menhinick's Richness Index 5.57; Margalef Richness Index 16.34; Shannon Sspecies Diversity index 4.07, Simpson Diversity Index 0.98; type evenness index 0.90; Most Abundance Species is Jambu-jambu B (Syzygium spp. B) 3.30 and Importance Values Index with dominan species is Tagaron ( Crataeva adansonii) 7.51. This arboretum area is a secondary forest area that has been cleared in several parts which can be maximized in its management with various methods for saving nature, recreation, education and research and other zones including animal breeding.
Komodifikasi Pada Upacara Simah Laut Di Desa Ujung Pandaran Kecamatan Teluk Sampit Kabupaten Kotawaringin Timur, Kalimantan Tengah
Authors: Rahmawati Yeni 
Published: April 2021

Upacara simah laut adalah salah satu kebudayaan masyarakat pesisiryang ada di Kabupaten Kotawaringin Timur, Kalimantan Tengah.Upacara ini sekitar tahun 2007 dijadikan pemerintah setempat sebagai salah satu program kerja Dinas Kebudayaan dan Pariwisata setempat.Upaya pemerintah untuk mempromosikan daerah dengan menggunakan upacara simah laut membuat upacara ini menjadi terkomodifikasi. Penelitian ini bertujuan untuk:(I) mengetahui bagaimana prosesi upacara simah laut. (II)mengetahuibagaimana makna simah laut bagi pelaksana upacara, pengunjung, pedagang, dan pemerintah. (III) mengetahui bagaimana upaya pemerintah dalam mengembangkan upacara simah laut sebagai sebuah komoditas. Penelitan ini menggunakan metode kualitatif. Teknik pengumpulan data adalah purposive sampling. Instrument penelitian adalah peneliti sendiri. Hasil dari penelitian menunjukkan bahwa dalam prosesi upacara simah laut terdapat unsur upacara tradidisional yaitu berkorban, bersaji, berdoa, dan makan bersama. Makna upacara simah laut bagipelaksanaupacara dapat memberi kesejahteraan, ketentram, juga keselamatan, sebagai identitas masyarakat,serta keuntungan ekonomi. Bagi pengunjung sebagai hiburan dan pengetahuan. Bagi pedagang adalah kesempatan mendapat keuntungan ekonomi.Bagi pemerintah sebagai aset budaya serta keuntungan materil dan moril. Upaya pemerintah dalam mengembangkan upacara simah laut sebagai suatu komoditasyaitu dengan mempromosikan upacara ini melalui media elektronik, media cetak, dan media online.Dalam pengembangannya ternyata upacara simah laut mengalami komodifikasi dalam bentuk produksi, distribusi, dan konsumsi. Kata Kunci: Komodifikasi, Upacara, dan Simah Laut