bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variance components of ratings of physician-patient communication: A generalizability theory analysis
Authors: Röttele Nicole , Schlett Christian , Körner Mirjam , Farin-Glattacker Erik , Schöpf-Lazzarino Andrea C. , Voigt-Radloff Sebastian , Wirtz Markus A. 
Published: June 2021

Background
The ratings of physician-patient communication are an important indicator of the quality of health care delivery and provide guidance for many important decisions in the health care setting and in health research. But there is no gold standard to assess physician-patient communication. Thus, depending on the specific measurement condition, multiple sources of variance may contribute to the total score variance of ratings of physician-patient communication. This may systematically impair the validity of conclusions drawn from rating data.

Objective
To examine the extent to which different measurement conditions and rater perspectives, respectively contribute to the variance of physician-patient communication ratings.

Methods
Variance components of ratings of physician-patient communication gained from 32 general practitioners and 252 patients from 25 family practices in Germany were analyzed using generalizability theory. The communication dimensions “shared decision making”, “effective and open communication” and “satisfaction” were considered.

Results
Physician-patient communication ratings most substantially reflect unique rater-perspective and communication dimension combinations (32.7% interaction effect). The ratings also represented unique physician and rater-perspective combinations (16.3% interaction effect). However, physicians’ communication behavior and the observed communication dimensions revealed only a low extent of score variance (1% physician effect; 3.7% communication dimension effect). Approximately half of the variance remained unexplained (46.2% three-way interaction, confounded with error).

Conclusion
The ratings of physician-patient communication minimally reflect physician communication skills in general. Instead, these ratings exhibit primarily differences among physicians and patients in their tendency to perceive shared decision making and effective and open communication and to be satisfied with communication, regardless of the communication behavior of physicians. Rater training and assessing low inferential ratings of physician-patient communication dimensions should be considered when subjective aspects of rater perspectives are not of interest.
Medication-related hospital readmissions within 30 days of discharge—A retrospective study of risk factors in older adults
Authors: Glans Maria , Kragh Ekstam Annika , Jakobsson Ulf , Bondesson Åsa , Midlöv Patrik 
Published: June 2021

Background
Previous studies have shown that approximately 20% of hospital readmissions can be medication-related and 70% of these readmissions are possibly preventable. This retrospective medical records study aimed to find risk factors associated with medication-related readmissions to hospital within 30 days of discharge in older adults (≥65 years).

Methods
30-day readmissions (n = 360) were assessed as being either possibly or unlikely medication-related after which selected variables were used to individually compare the two groups to a comparison group (n = 360). The aim was to find individual risk factors of possibly medication-related readmissions focusing on living arrangements, polypharmacy, potentially inappropriate medication therapy, and changes made to medication regimens at initial discharge.

Results
A total of 143 of the 360 readmissions (40%) were assessed as being possibly medication-related. Charlson Comorbidity Index (OR 1.15, 95%CI 1.5–1.25), excessive polypharmacy (OR 1.74, 95%CI 1.07–2.81), having adjustments made to medication dosages at initial discharge (OR 1.63, 95%CI 1.03–2.58) and living in your own home, alone, were variables identified as risk factors of such readmissions. Living in your own home, alone, increased the odds of a possibly medication-related readmission 1.69 times compared to living in your own home with someone (p-value 0.025) and 2.22 times compared to living in a nursing home (p-value 0.037).

Conclusion
Possibly medication-related readmissions within 30 days of discharge, in patients 65 years and older, are common. The odds of such readmissions increase in comorbid, highly medicated patients living in their own home, alone, and if having medication dosages adjusted at initial discharge. These results indicate that care planning before discharge and the provision of help with, for example, managing medications after discharge, are factors especially important if aiming to reduce the amount of medication-related readmissions among this population. Further research is needed to confirm this hypothesis.
Proměny konceptu zoo jako reflexe vztahu člověka a přírody
Authors: Nekolný Lukáš 
Published: June 2021

V průběhu historie lidstva se jeho vztah k přírodě a zvířatům měnil. Zoo jsou typickým sociálním konstruktem, který tento vztah vyjadřuje a reprezentuje. Tento článek se proto věnuje reflexi jejich vývoje a diskuzi současného stavu. Dlouhou dobu zoo antropocentricky působily jako symbol lidské kontroly nad přírodou. Se změnami společnosti se však měnily jejich role a podoba. Zoo 19. století k dosavadní zábavě a rekreaci přidaly výzkum a vzdělávání, což bylo ve 20. století rozšířeno o ochranu přírody. Ve vědecky řízených zoo aktuálně dochází ke klíčovému propojování těchto funkcí – v ideálním případě do ochranářského edutainmentu. Vznikají zážitkově a ekocentricky pojaté areály, v nichž mizí bariéry a návštěvníci se vnořují do prostředí společného se zvířaty. Záchrana druhu je nově dávána nad význam jedince. Aktuální stav je nicméně reflexí koevolučního vývoje, který se eklekticky zaznamenává do jejich podoby a zachycuje i mnohé z minulosti, nejen nejnovější trendy.
The (1, 2)-step competition graph of a hypertournament
Authors: Li Ruijuan , An Xiaoting , Zhang Xinhong 
Published: June 2021

Abstract
In 2011, Factor and Merz [Discrete Appl. Math. 159 (2011), 100–103] defined the

(

1
,
2

)

\left(1,2)

-step competition graph of a digraph. Given a digraph

D
=

(

V
,
A

)

D=\left(V,A)

, the

(

1
,
2

)

\left(1,2)

-step competition graph of D, denoted

C

1
,
2

(

D

)

{C}_{1,2}\left(D)

, is a graph on

V

(

D

)

V\left(D)

, where

x
y
∈
E

(

C

1
,
2

(

D

)

)

xy\in E\left({C}_{1,2}\left(D))

if and only if there exists a vertex

z
≠
x
,
y

z\ne x,y

such that either

d

D
−
y

(

x
,
z

)

=
1

{d}_{D-y}\left(x,z)=1

and

d

D
−
x

(

y
,
z

)

≤
2

{d}_{D-x}(y,z)\le 2

or

d

D
−
x

(

y
,
z

)

=
1

{d}_{D-x}(y,z)=1

and

d

D
−
y

(

x
,
z

)

≤
2

{d}_{D-y}\left(x,z)\le 2

. They also characterized the (1, 2)-step competition graphs of tournaments and extended some results to the

(

i
,
j

)

\left(i,j)

-step competition graphs of tournaments. In this paper, the definition of the (1, 2)-step competition graph of a digraph is generalized to a hypertournament and the (1, 2)-step competition graph of a k-hypertournament is characterized. Also, the results are extended to

(

i
,
j

)

\left(i,j)

-step competition graphs of k-hypertournaments.
Dogs are final hosts of Sarcocystis morae (Apicomplexa: Sarcocystidae): First report of this species in Hungary and its region – Short communication
Authors: Tuska-Szalay Barbara , Takács Nóra , Kontschán Jenő , Vizi Zsuzsanna , Hornok Sándor 
Published: June 2021

AbstractIn this study, faecal samples of four American Staffordshire terrier dogs (used for illegal fighting) were analysed by DNA extraction, molecular-phylogenetic and parasitological methods, in order to examine the occurrence of protozoan, apicomplexan parasites. In one sample, the DNA of Sarcocystis morae was shown to be present. This species was identified based on 100% identity with already reported sequences of S. morae from cervids in Lithuania and Spain. The result was also confirmed by phylogenetic analysis. The sporocysts of the canine S. morae isolate measured 14.95 × 9.75 μm on average. This is the first molecular evidence in support of the final host role of domestic dogs in the life cycle of S. morae. The most likely source of the infection was raw meat given to the examined dog to increase its physical achievement. In conclusion, under similar circumstances dogs may participate in the life cycle of S. morae in a ‘natural way’, shedding sporocysts/oocysts when used for hunting or taken to walks in forested areas.
Effect of combination antihypertensive therapy, including renin-angiotensin-aldosterone system inhibitors, on oxidative stress and arterial remodeling in hypertensive patients with heart failure with preserved ejection fraction
Authors: Akhilgova Z. M. , Roitman A. P. , Rakova N. G. , Bugrov A. V. , Pavlovskaya E. A. , Zastrozhin M. S. , Avtandilov A. G. 
Published: June 2021

Aim. To study the effect of triple combination therapy on oxidative stress and arterial remodeling in hypertensive patients with heart failure with preserved ejection fraction (HFpEF).Material and methods. The study involved 76 people with diagnosed HFpEF. After a comprehensive examination, patients were randomized into two equal groups: first group — patients who received perindopril 10 mg, indapamide 2,5mg and amlodipine 5 mg; second — patients who received losartan 100 mg, indapamide 2,5 mg, amlodipine 5 mg. Before and 16 weeks after the therapy initiation, cardiac ultrasound, assessment of endothelial function with estimating endothelium-dependent vasodilation, assessment of vascular stiffness by photoplethysmography and compression oscillometry were carried out. The plasma concentration of oxidative stress marker 8-isoprostane was studied.Results. During the follow-up period, a significant improvement in endothelial function was noted: in the first group — from 8,1% to 11,4% (p=0,001), in the second — from 5,8% to 8,3% (p=0,0007). In both groups, there was an improvement in microvessel elasticity: a significant decrease in specific peripheral vascular resistance, as well as a significant decrease in total peripheral resistance in the first group (p<0,002) and a tendency to decrease in the second one (p>0,05). There was a significant increase in the stiffness of the aorta and muscular arteries in both groupsю In the first group, a stiffness index decreased from 10,38 m/s to 8,33 m/s (p<0,0001), in the second — from 10,6 m/s to 9,3 m/s (p<0,01). In addition, resistance index in the first group decreased from 71,5% to 60% (p<0,0001), while in the second — from 68% to 60% (p=0,006). Also, both groups showed a significant decrease in the left atrial diastolic dimension and the left atrial volume index. A decrease in the 8-isoprostane plasma levels was noted, which indicates a decrease in oxidative stress.Conclusion. Oxidative stress, which develops due to chronic systemic inflammation, plays a key role in the pathogenesis of HFpEF. The results obtained show an improved endothelial function as a result of decrease in oxidative stress, which is accompanied by an improvement in vessel wall elasticity, thereby slowing down the heart failure progression.
Hormonal determinants of prehypertension in a random sample of St. Petersburg residents: data from the ESSE-RF study
Authors: Erina A. M. , Boyarinova M. A. , Moguchaya E. V. , Kolesova E. P. , Vasilyeva E. Yu. , Alieva A. S. , Paskar N. A. , Rotar O. P. , Baranova E. I. , Konradi A. O. , Shlyakhto E. V. 
Published: June 2021

Aim. To determine the association of prehypertension (PHTN) with cardiometabolic and hormonal factors in a population sample of St. Petersburg residents.Material and methods. As part of the ESSE-RF epidemiological study, a random sample of 1600 residents of St. Petersburg at the age of 25-64 was examined. All participants signed informed consent and completed the questionnaires. Anthropometry, fasting venous blood sampling, blood pressure (BP) measurements were performed. BP was measured by the OMRON BP monitor (Japan) twice on the right hand in a sitting position. Mean BP was calculated. Respondents, depending on the BP level and availability of antihypertensive therapy, were divided into 3 groups: optimal BP (<120/80 mm Hg), PHTN (120-139/80-89 mm Hg) and HTN (≥140/90 mm Hg or antihypertensive therapy). Blood levels of insulin, N-terminal pro-brain natriuretic peptide (NT-proBNP), thyroid-stimulating hormone, C-reactive protein (CRP), morning cortisol, leptin, adiponectin were assessed. The insulin resistance index was calculated using the Homeostatic Model Assessment (HOMA) according to the following equation: glucose (mmol/l) × insulin (μIU/ml))÷22,5. Mathematical and statistical data analysis was carried out using the SPSS Statistics 26 program.Results. The data from 1591 participants were analyzed. Among the surveyed persons, women predominated (n=1025; 64,4%). With BP increase from optimal to PHTN, HTN, the levels of CRP, insulin, HOMA-IR and leptin increases in male and female respondents. In addition, there is an increased prevalence of hyperinsulinemia and insulin resistance in the female population. Multiple logistic regression, adjusted for sex, age, obesity ( body mass index ≥30 kg/m2) and waist circumference (≥102 cm for men and 88 cm for women), revealed associations of PHTN with an increase in insulin >173,0 pmol/L (2,99 [1,22; 7,36], p=0,017), HOMA-IR >2,9 (2,12 [1,42; 3,19], p<0,0001) and associations of HTN with an increase in insulin >173,0 pmol/L (2,14 [1,30; 3,54], p=0,003), HOMA-IR >2,9 (1,83 [1,39; 2,42 ], p536 nmol/L (1,59 [1,25; 2,05], p125 pg/ml (2,05 [1,32; 3,20], p=0,002).Conclusion. In a random sample of St. Petersburg residents, the presence of hyperinsulinemia increases the risk of PHTN and insulin resistance by 3 and 2 times, respectively.
Eating habits among the Omsk Oblast population and poor nutrition in association with cardiovascular diseases according to the ESSE-RF2 study
Authors: Viktorova I. A. , Stasenko V. L. , Shirlina N. G. , Muromtseva G. A. , Livzan M. A. 
Published: June 2021

Aim. To assess the prevalence of eating habits among the Omsk Oblast population and their association with cardiovascular diseases (CVDs) according to the ESSERF2 study.Material and methods. In the ESSE-RF2 study with persons aged 25-64 years (random sample, n=1648), the dietary habits of 21 food groups were assessed using the questionnaire method. Results. Insufficient consumption of vegetables and fruits was revealed in 60,0% and 68,7% of the region’s population, which is 1,5-2,2 times higher than amongRussians. The daily intake of cereals is 2,3 times higher than that of pasta, especially in those with CVDs. In the region, poultry is preferred. Poultry at least once a week is consumed by 91,7% of Omsk residents, red meat — 74,8%, and fish — only 35,2% (vs 84,7%, 83,1% and 65,1% in Russians, respectively). The daily intake of liquid dairy products is low. Cheese and cottage cheese is consumed significantly lower than the national average, while legumes — 4 times lower. The presence of confectionery in the daily diet of 40,3% of Omsk residents looks more favorable than the average among Russians. In addition, 50% of the population eat pickles only 1-2 times a month (significantly less than in Russia). On the contrary, 60,9% of Omsk residents regularly (daily-weekly) consume meat and sausages (56,0% in Russia, p=0,000). Omsk residents with CVDs refrain from excessive consumption of sugar, other sweets, meat and sausages, pickles and marinades. They are almost 2 times more likely to exclude red meat from the diet or reduce its daily consumption than people without CVDs. Salting of cooked food, consumption of vegetables and fruits, fish, seafood and dairy products practically did not depend on CVDs.Conclusion. The food habits of Omsk residents differs from the national one in many products. People with CVDs have unfavorable eating habits: reduced consumption of fresh vegetables, fruits, fish, seafood, legumes and nuts. Patients do not change their diet in favor of cardioprotective products and decrease in adding more salt. Although, they more often refuse meat and sausages, pickles, marinades, sweets, and pasta, and increase the consumption of cereals.
Changes in mortality rates from acute types of coronary artery disease in Russia for the period from 2015 to 2019
Authors: Drapkina O. M. , Bubnova M. G. , Samorodskaya I. V. , Akulova O. A. , Aronov D. M. 
Published: June 2021

Aim. To identify regional specifics of changes in mortality rates from acute types of coronary artery disease (CAD) in 82 Russian regions for the period from 2015 to 2019.Material and methods. The study used data from the Federal State Statistics Service of Russia on mortality from acute CAD types in 82 Russian regions. Standardized death rates (SDRs) for 2015 and 2019 were estimated based on the European standard. We analyzed the SDRs of the population from acute (primary) and recurrent myocardial infarction (MI), other acute CAD types (I21-I22, I24.8 in the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10)).Results. Over the period from 2015 to 2019, mortality from all acute CAD types decreased by 21%, from acute MI — by 9%, from recurrent MI — by 22%, from any MI (acute/recurrent) recurrent — by 14%, and from other CAD types — by 21%. A decrease in mortality from all acute CAD types was recorded in 69 regions, from acute MI — in 58 regions, and recurrent MI — in 62 regions. However, a simultaneous decrease in SDRs from each of the acute CAD types (acute MI, recurrent MI and other acute CAD types) for the period 2015-2019 occurred only in 29 Russian regions. An increase in mortality from all acute CAD types was noted in 14 regions and from any MI — in 21 regions. The coefficient of variation (Cv) for recurrent MI and other acute CAD types of 69% and 103%, respectively, in 2015 and its growth (up to 75% and 134%, respectively) by 2019 indicate growing problems with the coding of death causes.Conclusion. In 2019, compared to 2015, a decrease in mortality from acute CAD types was recorded in most Russian regions. The identified regional specifics require clarification of approaches to death cause coding and the introduction of additions to mortality reduction programs, taking into account the specifics of each Russian region.
Antibody and T Cell Response to SARS-CoV-2 Messenger RNA BNT162b2 Vaccine in Kidney Transplant Recipients and Hemodialysis Patients
Authors: Bertrand Dominique , Hamzaoui Mouad , Lemée Veronique , Lamulle Julie , Hanoy Mélanie , Laurent Charlotte , Lebourg Ludivine , Etienne Isabelle , Lemoine Mathilde , Le Roy Frank , Nezam Dorian , Plantier Jean-Christophe , Boyer Olivier , Guerrot Dominique , Candon Sophie 
Published: June 2021

Significance Statement
Antibody and T cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines are poorly reported in kidney transplant recipients (KTRs) and patients on hemodialysis (HDPs). The authors investigated the response to BNT162b2 vaccine in 45 KTRs and ten HDPs. After the second dose, 88.9% of HDPs and only 17.8% of KTRs developed anti–SARS-CoV-2 antibodies. A specific T cell response was induced in 100% of HDPs and 57.8% of KTRs. The immune response seemed influenced by the immunosuppressive regimen in KTRs, particularly tacrolimus and belatacept. These results could help to better define the strategy of vaccination in this immunocompromised population.

Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in patients with ESKD, and vaccination is hoped to prevent infection.

Methods
Between January 18 and February 24, 2021, 225 kidney transplant recipients (KTRs) and 45 patients on hemodialysis (HDPs) received two injections of mRNA BNT162b2 vaccine. The postvaccinal humoral and cellular response was explored in the first 45 KTRs and ten HDPs.

Results
After the second dose, eight HDPs (88.9%) and eight KTRs (17.8%) developed antispike SARS-CoV-2 antibodies (P<0.001). Median titers of antibodies in responders were 1052 AU/ml (IQR, 515–2689) in HDPs and 671 AU/ml (IQR, 172–1523) in KTRs (P=0.40). Nine HDPs (100%) and 26 KTRs (57.8%) showed a specific T cell response (P=0.06) after the second injection. In responders, median numbers of spike-reactive T cells were 305 SFCs per 106 CD3+ T cells (IQR, 95–947) in HDPs and 212 SFCs per 106 CD3+ T cells (IQR, 61–330) in KTRs (P=0.40). In KTRs, the immune response to BNT162b2 seemed influenced by the immunosuppressive regimen, particularly tacrolimus or belatacept.

Conclusion
Immunization with BNT162b2 seems more efficient in HDPs, indicating that vaccination should be highly recommended in these patients awaiting a transplant. However, the current vaccinal strategy for KTRs may not provide effective protection against COVID-19 and will likely need to be improved.
Yusuf Ziya Paşa’nın Hayatı Ve Keban’da Yaptırdığı Konak Hamamı
Authors: YILDIRIM Selda , AYTAÇ İsmail 
Published: June 2021

Bu makalede nitel çalışma yöntemi kullanılmıştır. Yusuf Ziya Paşa’nın hayatı ve vakfetmiş olduğu eserlerden Elazığ İli Keban İlçesi’nde yer alan Konak Hamamı tanıtılarak, Osmanlı Siyasi ve Türk-İslam Sanatı Tarihi bakımından önemi değerlendirilmiştir. Yusuf Ziya Paşa, çeşitli alanlarda aldığı eğitimler ve kabiliyetinin bir sonucu olarak III. Selim ve II. Mahmut devirlerinde iki kez sadrazamlık olmak üzere birçok önemli görevde bulunmuştur. Bu özelliklerinin yanı sıra hayırsever bir kişiliğe sahip olan Paşa, kurmuş olduğu vakıflar yolu ile Malatya, Keban, Çemişgezek, Erzurum, Trabzon ve İstanbul gibi şehirlerde bani olarak, kendisinin yapmış olduğu hat levha örnekleriyle de Türk Sanatına katkılar sağlamış önemli bir devlet büyüğüdür. Yusuf Ziya Paşa’nın yaptırmış olduğu eserlerden makalemize konu olan Keban’daki konak hamamı büyük oranda tahrip olmuştur. Beden duvarları ayakta olan hamamın kubbe örtüsü tamamen çökmüştür. Hamam, 18. Yüzyıl sonu Osmanlı Mimarisini yansıtmaktadır. Bu yapı planı, malzemesi ve işlevi açıklandıktan sonra dönemi içerisinde değerlendirilmiştir.
La Suisse innove avec fide
Authors: MERCIER Dao 
Published: June 2021

Le système fide « Français, Italiano, Deutsch en Suisse », opérationnel depuis 2012, représente la volonté de la Suisse à promouvoir l’intégration linguistique des migrants adultes. En français, il s’intitule « fide français en Suisse – apprendre, enseigner, évaluer ». L’innovation de fide réside dans la cohérence de son système et dans ses principes didactiques s’inspirant du Cadre européen commun de référence pour les langues CECRL tout en respectant ceux déterminés dans l’andragogie ou la formation d’adultes. Ma contribution aura pour but de présenter le système fide en mettant l’accent sur cette application du CECRL dans ce contexte andragogique et ce, dans chaque étape du processus de l’apprentissage, de l’enseignement et de l’évaluation.
Les enjeux des cultures régionales chinoises dans la didactique du chinois langue étrangère et les perspectives pédagogiques innovantes
Authors: WANG Lei 
Published: June 2021

Lorsqu’un apprenant effectue son séjour en mobilité dans un pays comme la Chine, où les langues et les cultures régionales sont très variées et toujours vivantes, quelles conséquences peuvent avoir l’écart entre le capital linguistique et culturel standardisé que l’apprenant a acquis à l’école et ses expériences dans la région où il séjourne ? Comment l’apprenant mobilise-t-il ses compétences pour s’adapter à ces différences afin de réussir ? En travaillant sur le retour d’expériences des étudiants de chinois de l’Inalco, nous avons analysé les enjeux des cultures régionales dans la représentation, la compétence interculturelle et la motivation des étudiants. La fin de l’article est consacrée à des propositions pédagogiques qui visent à valoriser le séjour en mobilité des apprenants et à enrichir l’enseignement/l’apprentissage du chinois langue étrangère.