bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurodevelopmental Status of Moderate to Late Preterm Infants at 6 Months Corrected Age
Authors: Hoq Tanjina , Chowdhury Pranab Kumar , Ahmed Farid Uddin , Datta Mitra , Hafiz Promugdha , Das Rita 
Published: November 2021

Background: Moderate Preterm (MP) and Late Preterm (LP) infants together comprise more than 80% of all prematurely born infants. Since last decade, there has been growing concern about Neurodevelopmental Abnormality (NDA) in these infants. This study was aimed to assess neurodevelopmental status of moderate to late preterm born neonates and to determine factors associated with adverse neurodevelopmental outcome in a tertiary hospital in Bangladesh.
Materials and methods: In this prospective observational study 215 preterm (32 to <37 completed weeks gestation at birth) infants (107 MP and 108 LP) were enrolled from the Special Care Neonatal Unit (SCANU) Chittagong Medical College Hospital from June 2018 to May 2019. Neurodevelopmental assessment was done by Rapid Neurodevelopmental Assessment (RNDA) at 1, 3 and 6 months of Corrected Age (CA).
Results: Of the 215 enrolled children, 63 (29.3%) attended all the 3 follow-up, 123 (57.2%) had incomplete follow-up or lost and 29 (13.5%) died. At final follow-up out of 63 infants 43 (68.3%) had no abnormality in all 8 domains of RNDA. Seven infants (11.1%) had abnormality in one domain and 13 (20.6%) had abnormality in more than one domain. Gross motor abnormality was most common abnormality (28.6%), followed by cognition (14.3%), vision (12.7%) and behavior (12.7%). Small for gestational age and lower birth weight were found to be independent predictive factors for NDA in moderate to late preterm infants.
Conclusion: Study has shown that NDA persist till 6 months of CA in moderate to late preterm infants. It is important to closely monitor the neurodevelopmental status and provide early intervention in referred cases.
Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 50-54
Clinico-Pathological Profile of Cutaneous Lupus Erythematosus Patients: A Report from A Tertiary Care Center of Chattogram
Authors: Mowla Mohammad Rafiqul , Barua Deva Pratim , Zaman Shakila , Hossain Chowdhury Mohammad Ismail , Dutta Papri , Ali Mridha Md Wazed 
Published: November 2021

Background : Nearly all epidemiologic studies have involved patients with Systemic Lupus Erythematosus (SLE). Few authors have investigated the characteristics of patients with Cutaneous Lupus Erythematosus (CLE). We aim to describe the epidemiologic, clinical, and immunologic characteristics of a series of patients diagnosed with CLE.
Materials and methods : This is a descriptive retrospective cross-sectional study carried out using the register records of total 218 patients attending the ‘Lupus Clinic’ in Chittagong Medical College Hospital during the period 2010 and 2020. The disease activity and damage of CLE were assessed according to the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI).
Results : There were 187 females (86%) and 31 males (14%) with the female: male ratio being 6.1:1. The mean age was 28 ± 10.06 (mean ± SD) ranging between 11 and 65 years. The Chronic Cutaneous Lupus Erythematosus (CCLE) patients accounted 154 (71%) followed by Acute Cutaneous Lupus Erythematosus (ACLE) 46 (21%) and Subacute Cutaneous Lupus Erythematosus (SCLE) 18 (8%). On the basis of CLASI score, 91 (42%) patients were in mild form, 85 (39%) in moderate form and 42 (19%) in severe state. In LE specific skin lesions, common manifestation was photosensitivity 198 (91%) followed by discoid rash 154 (71%) and maculo-papular lupus rash 55 (25%). Oral ulcer was seen in 49 (22%) patients and malar rash in 46 (21%) patients. Other observed LE specific skin manifestations were papulo squamous rash 11 (5%), Toxic epidermal necrolysis like lesions 7 (3%) and lichenoid lesions 6 (3%). Among LE nonspecific skin lesions, common manifestation was nonscarring alopecia 123 (56%) followed by Raynaud’s phenomenon 17 (8%) livedo reticularis 17 (8%) Vasculitis 15 (7%) Periungual telangiectasia 7 (3%) erythema multiforme 6 (3%) and leg Ulcer 5 (2%). Antinuclear Antibody (ANA) 132 (61%) was the most common autoantibody followed by anti-ds DNA 91 (42%) anti-Sm antibody 2 (1%) anti-phospholipid antibodies 9 (4%) and anti-RNP 3 (1%). Hematological manifestations were seen in 161 (73.85%) where erythrocyte sedimentation rate was the most common hematological abnormality 161(73.85%) followed by lymphopenia 126 (57.80%) leucopenia 113 (51.80%) thrombocytopenia 107 (49.10%) anemia 92 (42%) monocytopenia 37 (16.97%). Conclusions: CCLE was the most common subtypes of CLE. Patients with different subtypes of CLE have distinct clinical and pathological characteristics. The onset or concurrence of SLE mandates the involvement of other disciplines depending on organ involvement. In the absence of consensus on a definition that makes it possible to differentiate cutaneous forms of LE from SLE, the dermatologist’s role in the correct diagnosis and classification of such patients is fundamental.
Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 79-84
Placental Polyp : A Rare Case Report
Authors: Yeasmin Most Sabina , Nourin Nishat Anjum , Begum Tahera , Mabud Farah Naz , Surovi Farjana Ahmed 
Published: November 2021

Placental polyp is the retained fragment of placental tissue which presents as a polypoidal or pedunculated mass within the uterus. It is a rare entity and has an incidence of less than 0.25 % of all pregnancies. There are also very few reported cases of the clinical placental polyp. Here,we report a case of 22-year-old P1 woman presenting with vaginal bleeding and something coming down into vagina.Her last pregnancy had occurred one year ago.Laboratory investigation revealed slightly elevated serum b-hCG. Ultrasonography revealed thick endometrium, broad cervix (5.2cm) and a hyperechoic mass within the cervix. Extraction of the placental polyp followed by endometrial curettage were done and tissue sent for histopathology. Definite diagnosis was made by histopathological examination and which was a placental polyp.
Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 85-88
Carrying capacity analysis of nature tourism at Selabintana, Gunung Gede Pangrango National Park, West Java
Authors: Sofiyudin Andriyatno , Rosadi Rosadi , Priatna Dolly 
Published: November 2021

Selabintana management area is one of the nature tourism areas in the Gunung Gede Pangrango National Park (GGPNP) which located in Sukabumi District, West Java. Within the management area which covers 2,547.93 ha, there is a camping ground and waterfall which both are the most attracted for visitors. Efforts are needed to harmonize nature tourism activities with conservation mission, so that visitors can enjoy but the natural environment is maintained. The objective of this research is to determine the carrying capacity for daily tourism and camping activities by considering the aspect of physical, environmental and management aspects. The survey conducted through interviews and questionnaires to 62 tourists, traders and managers of the national park area. The data were analyzed using the carrying capacity assessment method developed by Cifuentes, i.e. calculating the Physical Carrying Capacity (PCC), Real Carrying Capacity (RCC), and Effective Carrying Capacity (ECC). As a result, EEC for daily tourism is 84 visitors/day (PCC RCC ECC with a score of 3,269 98 84), while EEC for camping is 60 visitors/day (PCC RCC with a score of 2,155 69 60). Thus, carrying capacity of nature tourism activities in conservation areas can be calculated based on physical carrying capacity, real carrying capacity, and effective carrying capacity.Kawasan pengelolaan Selabintana merupakan salah satu areal wisata alam yang ada di Taman Nasional Gunung Gede Pangrango (TNGGP) yang terletak di Kabupaten Sukabumi, Jawa Barat. Di dalam areal pengelolaan yang luasnya 2.547,93 ha terdapat camping ground dan air terjun yang merupakan daya tarik utama yang bagi para pengunjung. Diperlukan adanya upaya untuk menyelarasakan kegiatan wisata alam dengan misi konservasi, agar pengunjung dapat menikmati namun lingkungan alam tetap terjaga. Tujuan dari penelitian ini adalah menentukan carrying capacity untuk kegiatan wisata harian dan berkemah dengan mempertimbangkan aspek fisik, lingkungan dan manajemen. Survey dilakukan melalui interview dan kuisioner terhadap 62 wisatawan, pedagang dan pengelola kawasan taman nasional. Data dianalisis dengan metode penilaian carrying capacity yang dikembangkan oleh Cifuentes, yaitu menghitung Daya Dukung Fisik (PCC), Daya Dukung Ril (RCC), serta Daya Dukung Efektif (ECC). Sebagai hasil, EEC untuk wisata harian adalah 84 pengunjung/hari (PCC RCC ECC dengan skor 3.269 98 84), sedangkan EEC untuk berkemah adalah 60 pengunjung/hari (PCC RCC dengan skor 2.155 69 60). Jadi, carrying capacity dalam kegiatan wisata alam di dalam kawasan konservasi dapat ditentukan berdasarkan daya dukung fisik, daya dukung riil, dan daya dukung efektif.
Correlation between the willingness to compromise and effectiveness of regional regulations with green consumer behaviour
Authors: Lina Lina , Retnowati Rita , Istiadi Yossa 
Published: November 2021

The objective of this study is to find the correlation between the effectiveness level of regional regulations and willingness to compromise with green consumer behaviour. This research applied use correlational surveys with 100 samples housewives in Bogor city. The data analysis technique used is multiple regression. The result of this research shows that there is a very significant positive relationship that has a local regulation permit with green consumer behaviour, with a variable contribution of 56.2%. There is a very significant positive relationship between willingness to compromise with green consumer behaviour, with the variable contribution being 38.3%. There is a very significant positive relationship between the application of local regulations and the willingness to compromise together with green consumer behaviour, with the variable contribution being 57.9%. The functional relationship between the application of local regulations and willingness to compromise with the green consumer behaviour variable fulfills the regression equation Ŷ12 = 21.866 + 0.404X1 + 0.214X2 and this relationship is significant.Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara tingkat efektivitas peraturan daerah dan kemauan berkompromi dengan perilaku konsumen hijau. Penelitian ini menggunakan metode survei korelasional dengan sampel 100 ibu rumah tangga di kota Bogor. Teknik analisis data yang digunakan adalah regresi berganda. Hasil penelitian menunjukkan bahwa terdapat hubungan positif yang sangat signifikan antara izin peraturan daerah dengan perilaku konsumen hijau, dengan kontribusi variabel sebesar 56,2%. Terdapat hubungan positif yang sangat signifikan antara kesediaan berkompromi dengan perilaku konsumen hijau, dengan kontribusi variabel sebesar 38,3%. Terdapat hubungan positif yang sangat signifikan antara penerapan peraturan daerah dengan kemauan berkompromi dengan perilaku konsumen hijau, dengan kontribusi variabel sebesar 57,9%. Hubungan fungsional antara penerapan peraturan daerah dan kemauan berkompromi dengan variabel perilaku konsumen hijau memenuhi persamaan regresi 12 = 21,866 + 0,404X1 + 0,214X2 dan hubungan ini signifikan.
Mechanical Properties of Isolated Primary Cilia Measured by Micro-tensile Test and Atomic Force Microscopy
Authors: Do Tien-Dung , Katsuyoshi Jimuro , Cai Haonai , Ohashi Toshiro 
Published: November 2021

Mechanotransduction is a well-known mechanism by which cells sense their surrounding mechanical environment, convert mechanical stimuli into biochemical signals, and eventually change their morphology and functions. Primary cilia are believed to be mechanosensors existing on the surface of the cell membrane and support cells to sense surrounding mechanical signals. Knowing the mechanical properties of primary cilia is essential to understand their responses, such as sensitivity to mechanical stimuli. Previous studies have so far conducted flow experiments or optical trap techniques to measure the flexural rigidity EI (E: Young’s modulus, I: second moment of inertia) of primary cilia; however, the flexural rigidity is not a material property of materials and depends on mathematical models used in the determination, leading to a discrepancy between studies. For better characterization of primary cilia mechanics, Young’s modulus should be directly and precisely measured. In this study, the tensile Young’s modulus of isolated primary cilia is, for the first time, measured by using an in-house micro-tensile tester. The different strain rates of 0.01–0.3 s−1 were applied to isolated primary cilia, which showed a strain rate–dependent Young’s modulus in the range of 69.5–240.0 kPa on average. Atomic force microscopy was also performed to measure the local Young’s modulus of primary cilia, showing the Young’s modulus within the order of tens to hundreds of kPa. This study could directly provide the global and local Young’s moduli, which will benefit better understanding of primary cilia mechanics.
Accurate Analysis of Anisotropic Carrier Mobility and Structure–property Relationships in Organic BOXD Crystalline Materials
Authors: Wang Shi-Ping , Wang Yu , Chen Fang-Yi , Wang Hai-Tao , Sheong Fu-Kit , Bai Fu-Quan , Zhang Hong-Xing 
Published: November 2021

Charge mobility is an essential factor of organic crystalline materials. Although many investigators have made important progress, the exact relationship between the crystal structure and carrier mobility remains to be clarified. Fortunately, a series of bis-1,3,4-oxadiazole derivatives have been successfully prepared and reported. They have similar main molecular fragments but different crystal packing modes, which provide an ideal research objective for studying the effect of molecular packing on charge mobility in organic photoelectric conversion systems. In this work, the charge mobilities of these molecules are systematically evaluated from the perspective of first-principles calculation, and the effect of a molecular overlap on orbital overlap integral and final charge carrier mobility is fully discussed. It can be seen that the small intermolecular distance (less than 6 Å) is the decisive factor to achieve high electron mobility in π stacking, and better mobility can be obtained by increasing the hole migration distance appropriately. A larger dihedral angle of anisotropy is an important point limiting the charge mobility in the herringbone arrangement. It is hoped that the correlation results between the crystal structure and mobility can assist the experimental study and provide an effective way to improve the photoelectric conversion efficiency of the organic semiconductor devices and multiple basis for multiscale material system characterization and material information.
Post-interventional Evaluation and Follow-Up in Children With Patent Ductus Arteriosus Complicated With Moderate to Severe Pulmonary Arterial Hypertension: A Retrospective Study
Authors: Rong Xing , Ye Qiaofang , Wang Qiaoyu , Wang Jiajun , Zhu Qiongjun , Chen Youran , Wu Rongzhou 
Published: November 2021

Background:Transcatheter closure is an important treatment for patent ductus arteriosus (PDA) complicated with moderate and severe pulmonary arterial hypertension (PAH). This report presents our experience with transcatheter closure of PDA complicated with moderate and severe PAH.Methods:The 49 cases of PDA complicated with moderate and severe PAH were collected in the Second Affiliated Hospital and Yuying Children's Hospital from January 2014 to December 2019 with transcatheter closure of PDA and follow-up. All patients were invited for transthoracic echocardiography, electrocardiogram, and thoracic radiography check-up.Results:Device implantation was successful in 48 of 49 patients (98.0%). Among them, 30 cases were in the PAH after defect correction (CD) group, and 19 examples were in the Non-PAH after defect correction (NCD) group. Pulmonary systolic pressure, left atrial diameter, and left ventricular end-diastolic diameter immediately after interventional therapy and 6 months later were lower than the pre-operative levels (p&lt; 0.05). The incidence of the immediate residual shunt (RS) in this study was 34.9%, most of which were minimal amount shunt. RS disappeared in all patients within 1 year of therapy. Four patients had thrombocytopenia and one patient had left pulmonary artery stenosis. No other serious adverse event occurred during the follow-up period. The pressure gradient tricuspid valve regurgitation (PGTI) and the right heart catheterization (RHC) consistency points were 93.75% (15/16) and were within the 95% consistency limit by the Bland-Altman method. The Logistic regression analysis concluded that the pre-operative Pp/Ps and the narrowest diameter of PDA are risk factors for post-operative PAH (p&lt; 0.05). The cut-off point of the pre-operative Pp/Ps and the narrowest diameter of PDA were calculated to be 0.595 and 4.75 mm, respectively.Conclusion:Interventional occlusion in children with PDA complicated with moderate and severe PAH is safe, effective, and has few complications. Targeted drug therapy has a good clinical effect. The narrowest diameter of PDA and the pre-operative Pp/Ps may be one of the risk factors of residual PAH after interventional therapy.
Neurofilament Light Chain Protein Is a Predictive Biomarker for Stroke After Surgical Repair for Acute Type A Aortic Dissection
Authors: Zhang Kai , Wang Zhu , Zhu Kai , Dong Songbo , Pan Xudong , Sun Lizhong , Li Qing 
Published: November 2021

Background: Although great progress has been made in surgery and perioperative care, stroke is still a fatal complication of acute type A aortic dissection (ATAAD). Serum biomarkers may help assess brain damage and predict patient's prognosis.Methods: From March, 2019 to January, 2020, a total of 88 patients underwent surgical treatment at the Department of Cardiovascular Surgery of Beijing Anzhen Hospital, China, and were enrolled in this study. Patients were divided into two groups according to whether they had suffered a stroke after the operation. Blood samples were collected at 8 time points within 3 days after surgery to determine the level of S100β, neuron-specific enolase (NSE) and neurofilament light chain protein (NFL). Receiver operating characteristic curves (ROC) were established to explore the biomarker predictive value in stroke. The area under the curve (AUC) was used to quantify the ROC curve.Results: The patient average age was 48.1 ± 11.0 years old and 70 (79.6%) patients were male. Fifteen (17.0%) patients suffered stroke after surgery. The NFL levels of patients in the stroke group at 12 and 24 h after surgery were significantly higher than those in the non-stroke group (all P &lt; 0.001). However, the NSE and S100β levels did not differ significantly at any time point between the two groups. The predictive value of NFL was the highest at 12 and 24 h after surgery, and the AUC was 0.834 (95% CI, 0.723–0.951, P &lt; 0.001) and 0.748 (95% CI, 0.603–0.894, P = 0.004), respectively. Its sensitivity and specificity at 12 h were 86.7 and 71.6%, respectively. The NFL cutoff value for the diagnosis of stroke at 12 h after surgery was 16.042 ng/ml.Conclusions: This study suggests that NFL is an early and sensitive serum marker for predicting post-operative neurological prognosis of ATAAD patients. Further studies, including large-scale prospective clinical trials, are necessary to test whether the NFL can be used as a biomarker for clinical decision-making.
Cancer and Infective Endocarditis: Characteristics and Prognostic Impact
Authors: Cosyns Bernard , Roosens Bram , Lancellotti Patrizio , Laroche Cécile , Dulgheru Raluca , Scheggi Valentina , Vilacosta Isidre , Pasquet Agnès , Piper Cornelia , Reyes Graciela , Mahfouz Essam , Kobalava Zhanna , Piroth Lionel , Kasprzak Jarosław D. , Moreo Antonella , Faucher Jean-François , Ternacle Julien , Meshaal Marwa , Maggioni Aldo P. , Iung Bernard , Habib Gilbert 
Published: November 2021

Background: The interplay between cancer and IE has become of increasing interest. This study sought to assess the prevalence, baseline characteristics, management, and outcomes of IE cancer patients in the ESC EORP EURO-ENDO registry.Methods: Three thousand and eighty-five patients with IE were identified based on the ESC 2015 criteria. Three hundred and fifty-nine (11.6%) IE cancer patients were compared to 2,726 (88.4%) cancer-free IE patients.Results: In cancer patients, IE was mostly community-acquired (74.8%). The most frequently identified microorganisms were S. aureus (25.4%) and Enterococci (23.8%). The most frequent complications were acute renal failure (25.9%), embolic events (21.7%) and congestive heart failure (18.1%). Theoretical indication for cardiac surgery was not significantly different between groups (65.5 vs. 69.8%, P = 0.091), but was effectively less performed when indicated in IE patients with cancer (65.5 vs. 75.0%, P = 0.002). Compared to cancer-free IE patients, in-hospital and 1-year mortality occurred in 23.4 vs. 16.1%, P = 0.006, and 18.0 vs. 10.2%; P &lt; 0.001, respectively. In IE cancer patients, predictors of mortality by multivariate analysis were creatinine &gt; 2 mg/dL, congestive heart failure and unperformed cardiac surgery (when indicated).Conclusions: Cancer in IE patients is common and associated with a worse outcome. This large, observational cohort provides new insights concerning the contemporary profile, management, and clinical outcomes of IE cancer patients across a wide range of countries.
Harnessing the Potential of Human Pluripotent Stem Cell-Derived Motor Neurons for Drug Discovery in Amyotrophic Lateral Sclerosis: From the Clinic to the Laboratory and Back to the Patient
Authors: Lamas Nuno Jorge , Roybon Laurent 
Published: November 2021

Amyotrophic Lateral Sclerosis (ALS) is a motor neurodegenerative disorder whose cellular hallmarks are the progressive death of motor neurons (MNs) located in the anterior horn of the spinal cord, brainstem and motor cortex, and the formation of intracellular protein aggregates. Over the course of the disease, progressive paralysis takes place, leading to patient death within 3–5 years after the diagnosis. Despite decades of intensive research, only a few therapeutic options exist, with a limited benefit on the disease progression. Preclinical animal models have been very useful to decipher some aspects of the mechanisms underlying ALS. However, discoveries made using transgenic animal models have failed to translate into clinically meaningful therapeutic strategies. Thus, there is an urgent need to find solutions to discover drugs that could impact on the course of the disease, with the ultimate goal to extend the life of patients and improve their quality of life. Induced pluripotent stem cells (iPSCs), similarly to embryonic stem cells (ESCs), have the capacity to differentiate into all three embryonic germ layers, which offers the unprecedented opportunity to access patient-specific central nervous system cells in an inexhaustible manner. Human MNs generated from ALS patient iPSCs are an exciting tool for disease modelling and drug discovery projects, since they display ALS-specific phenotypes. Here, we attempted to review almost 2 decades of research in the field, first highlighting the steps required to efficiently generate MNs from human ESCs and iPSCs. Then, we address relevant ALS studies which employed human ESCs and iPSC-derived MNs that led to the identification of compounds currently being tested in clinical trials for ALS. Finally, we discuss the potential and caveats of using patient iPSC-derived MNs as a platform for drug screening, and anticipate ongoing and future challenges in ALS drug discovery.