bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of artificial cycles with and without gonadotropin-releasing hormone agonist pretreatment on frozen embryo transfer outcomes in patients with adenomyosis
Authors: Li Muzi , Xu Lihong , Zhao Heng , Du Yanbo , Yan Lei 
Published: September 2021

AbstractGonadotropin-releasing hormone agonist (GnRH-a) is generally added to the improve pregnancy outcomes of hormone replacement therapy cycles among patients with adenomyosis. We aimed to investigate whether adding GnRH-a can result in better pregnancy outcomes. This retrospective analysis included 341 patients with adenomyosis who underwent frozen embryo transfer (FET) after in vitro fertilization (IVF). The control group was treated only with hormone replacement therapy cycles to prepare the endometrium, and GnRH-a was added to the study group before hormone administration to adjust the menstruation cycle. Based on the similar baseline values and embryological data, there was no significant difference in the clinical pregnancy rates (40.63% vs. 42.54%, P = 0.72) and live birth rates (23.75% vs. 23.75%, P = 0.74) of the control and study groups. Other secondary outcomes, including the rates of clinical miscarriage, ectopic pregnancy, preterm birth and term birth, were not significantly different between the two groups. Compared with the hormone replacement therapy cycle alone, GnRH-a downregulation based on a hormone replacement therapy cycle may not increase the rate of clinical pregnancy or live birth of IVF-ET with FET among infertile patients with adenomyosis.
Effects of common rice field weeds on the survival, feeding rate and feeding behaviour of the crayfish Procambarus clarkii
Authors: Yuan Quan , Tian Zhihui , Lv Weiwei , Huang Weiwei , Sun Xiaolin , Lv Weiguang , Bi Yonghong , Shen Guohui , Zhou Wenzong 
Published: September 2021

AbstractTo check if it is possible for crayfish to reduce the weed biomass in a paddy field, we hypothesised that crayfish can feed on common weeds in a paddy field. The feeding ability of red swamp crayfish, Procambarus clarkii, males and females for 4 weeds, Ludwigia prostrata Roxb., Leptochloa chinensis (L.) Nees, Echinochloa crusgalli (L.) Beauv and Eclipta prostrata L., commonly found in rice–crayfish fields were evaluated using a quantitative feeding experiment and behaviour observation experiment. The results of the quantitative feeding and behaviour experiments were highly consistent. The P. clarkii gender and weed species had no interactive effects on survival rate, the daily feed intake (FI) and percentage of daily feed intake (PFI). The results of the quantitative feeding experiment showed that the FI and PFI values of both P. clarkii females and males were significantly higher in the P. clarkii feed group than in the weed treatment group. Both FI and PFI were significantly higher in the L. chinensis group than in the other treatment groups. The survival rate of P. clarkii was significantly lower in the E. crusgalli group than in the other treatment groups. The behaviour observation experiment showed that the feeding frequency and duration were in the order of L. chinensis > E. prostrata > L. prostrata > E. crusgalli. The results indicate that the P. clarkii specimens liked to eat L. chinensis (mean PFI was more than 2%), hardly fed on E. crusgalli.
The safety and efficacy of high-speed train transport for critical children: a retrospective propensity score matching cohort study
Authors: Zhao Zhe , Liu Yingyue , Yang Baowang , Zhang Huiling , Liu Xiaohong , Zhu Yanjuan , Hong Xiaoyang , Feng Zhichun 
Published: September 2021

AbstractIt is widely acknowledged that efficiency of pediatric critical care transport plays a vital role in treatment of critically-ill children. In developing countries, most critically-ill children were transported by ambulance, and a few by air, such as a helicopter or fixed airplane. High-speed train (HST) transport may be a potential choice for critically-ill children to a tertiary medical center for further therapy. This is a single-center, retrospective cohort study from June 01, 2016 to June 30, 2019. All the patients transported to the Pediatric Intensive Care Unit (PICU) of PLA general hospital were divided into two groups, HST group and ambulance group. The propensity score matching method was performed for the comparison between the two groups. Finally, a 2:1 patient matching was performed using the nearest-neighbor matching method without replacement. The primary outcome was hospital mortality. Secondary outcomes included duration of transport, transport cost, hospital stay, and hospitalization cost. A total of 509 critically-ill children were transported and admitted. Of them, 40 patients were transported by HST, and 469 by ambulance. The hospital mortality showed no difference between the two groups (p > 0.05). The transport distance in the HST group was longer than that in the ambulance group (1894.5 ± 907.09 vs.902.66 ± 735.74,p < 0.001). However, compared to the HST group, the duration of transport time by ambulance was significantly longer (p < 0.001). No difference in vital signs, blood gas analysis, and critical illness score between groups at admission was noted (p > 0.05). There was no death during the transport. There was no difference between groups regarding the transport cost, hospital stays, and hospitalization cost (p > 0.05). High-quality tertiary medical centers are usually located in megacities. HST transport network for critically-ill children could be established to cover most regions of the country. Without increasing financial burden, HST medical transport can be a potentially promising option to improve the outcomes of critically-ill children in developing countries with developed HST network.Clinical Trial Registration: This study was registered athttp://www.chictr.org.cn/index.aspx(chiCTR.gov; Identifier: ChiCTR2000032306).
Molecular principles of recruitment and dynamics of guest proteins in liquid droplets
Authors: Kamagata Kiyoto , Iwaki Nanako , Hazra Milan Kumar , Kanbayashi Saori , Banerjee Trishit , Chiba Rika , Sakomoto Seiji , Gaudon Virginie , Castaing Bertrand , Takahashi Hiroto , Kimura Michiko , Oikawa Hiroyuki , Takahashi Satoshi , Levy Yaakov 
Published: September 2021

AbstractDespite the continuous discovery of host and guest proteins in membraneless organelles, complex host–guest interactions hinder the understanding of the molecular grammar governing liquid–liquid phase separation. In this study, we characterized the localization and dynamic properties of guest proteins in liquid droplets using single-molecule fluorescence microscopy. Eighteen guest proteins of different sizes, structures, and oligomeric states were examined in host p53 liquid droplets. Recruitment did not significantly depend on the structural properties of the guest proteins, but was moderately correlated with their length, total charge, and number of R and Y residues. In contrast, the diffusion of disordered guest proteins was comparable to that of host p53, whereas that of folded proteins varied widely. Molecular dynamics simulations suggest that folded proteins diffuse within the voids of the liquid droplet while interacting weakly with neighboring host proteins, whereas disordered proteins adapt their structures to form tight interactions with the host proteins. Our study provides insights into the key molecular principles of the localization and dynamics of guest proteins in liquid droplets.
Critical behavior of density-driven and shear-driven reversible–irreversible transitions in cyclically sheared vortices
Authors: Maegochi S. , Ienaga K. , Okuma S. 
Published: September 2021

AbstractRandom assemblies of particles subjected to cyclic shear undergo a reversible–irreversible transition (RIT) with increasing a shear amplitude d or particle density n, while the latter type of RIT has not been verified experimentally. Here, we measure the time-dependent velocity of cyclically sheared vortices and observe the critical behavior of RIT driven by vortex density B as well as d. At the critical point of each RIT, $$B_{\mathrm {c}}$$

B
c

and $$d_{\mathrm {c}}$$

d
c

, the relaxation time $$\tau $$
τ
to reach the steady state shows a power-law divergence. The critical exponent for B-driven RIT is in agreement with that for d-driven RIT and both types of RIT fall into the same universality class as the absorbing transition in the two-dimensional directed-percolation universality class. As d is decreased to the average intervortex spacing in the reversible regime, $$\tau (d)$$

τ
(
d
)

shows a significant drop, indicating a transition or crossover from a loop-reversible state with vortex-vortex collisions to a collisionless point-reversible state. In either regime, $$\tau (d)$$

τ
(
d
)

exhibits a power-law divergence at the same $$d_{\mathrm {c}}$$

d
c

with nearly the same exponent.
Nomograms for predicting the overall survival of patients with cerebellar glioma: an analysis of the surveillance epidemiology and end results (SEER) database
Authors: Li Jie , Huang Wobin , Chen Jiajing , Li Zhuhui , Liu Bocong , Wang Peng , Zhang Jun 
Published: September 2021

AbstractAt present, our understanding of cerebellar glioma is still insufficient. This study collected information on patients in the SEER database to identify the predictive factors for patients with cerebellar glioma. Data from patients with cerebellar glioma diagnosed from 1975 to 2018 were retrieved from the Surveillance Epidemiology and End Results Database. We randomly divided the patients into a training group and a validation group, established a nomogram based on the training group, and used the validation group data to verify the clinical value of the model. A total of 508 patients were included in this study. Multivariate analysis was performed based on the data before randomization, and the results showed that the patient's age, WHO grade, histological type, and extent were significantly correlated with the survival rate. The C-index of the OS nomograms of the training cohort was 0.909 (95% CI, (0.880–0.938)) and 0.932 (95% CI, (0.889–0.975)) in the validation group. The calibration curve of OS for 3 and 5 years showed that there was good consistency between the actual survival probability and the predicted survival probability. For patients with cerebellar glioma, the age at diagnosis, WHO grade of the glioma, histological type, and extension are the four factors that most strongly affect the overall survival outcomes. Furthermore, our model may be a useful tool for predicting OS in these patients.
Improved mechanical strength, proton conductivity and power density in an ‘all-protonic’ ceramic fuel cell at intermediate temperature
Authors: Azad Abul K. , Abdalla Abdalla M. , Afif Ahmed , Azad Atia , Afroze Shammya , Idris Azam Che , Park Jun-Young , Saqib Mohammad , Radenahmad Nikdalila , Hossain Shahzad , Elius Iftakhar Bin , Al-Mamun Md. , Zaini Juliana , Al-Hinai Amer , Reza Md. Sumon , Irvine John T. S. 
Published: September 2021

AbstractProtonic ceramic fuel cells (PCFCs) have become the most efficient, clean and cost-effective electrochemical energy conversion devices in recent years. While significant progress has been made in developing proton conducting electrolyte materials, mechanical strength and durability still need to be improved for efficient applications. We report that adding 5 mol% Zn to the Y-doped barium cerate-zirconate perovskite electrolyte material can significantly improve the sintering properties, mechanical strength, durability and performance. Using same proton conducting material in anodes, electrolytes and cathodes to make a strong structural backbone shows clear advantages in mechanical strength over other arrangements with different materials. Rietveld analysis of the X-ray and neutron diffraction data of BaCe0.7Zr0.1Y0.15Zn0.05O3−δ (BCZYZn05) revealed a pure orthorhombic structure belonging to the Pbnm space group. Structural and electrochemical analyses indicate highly dense and high proton conductivity at intermediate temperature (400–700 °C). The anode-supported single cell, NiO-BCZYZn05|BCZYZn05|BSCF-BCZYZn05, demonstrates a peak power density of 872 mW cm−2 at 700 °C which is one of the highest power density in an all-protonic solid oxide fuel cell. This observation represents an important step towards commercially viable SOFC technology.
Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats
Authors: Gillis Ellen E. , Belanger Kasey , Abdelbary Mahmoud , Mohamed Riyaz , Sun Jingping , Brands Michael W. , Sullivan Jennifer C. 
Published: September 2021

AbstractOver the past decade there has been increasing support for a role of the immune system in the development of hypertension. Our lab has previously reported that female spontaneously hypertensive rats (SHRs) have a blood pressure (BP)-dependent increase in anti-inflammatory renal regulatory T cells (Tregs), corresponding to lower BP compared with males. However, little is known regarding the mechanism for greater renal Tregs in females. The current study was designed to test the hypothesis that the greater relative abundance of renal Tregs in female SHR is due to greater Treg production. To test this hypothesis, T cell profiles were measured in the spleen by flow cytometry in male and female SHR at 5 and 14 weeks of age. Splenic Tregs did not differ between males and females, suggesting sex differences in renal Tregs is not due to differences in production. To assess the role of the spleen in sex differences in renal Tregs and BP control, rats were randomized to receive sham surgery (CON) or splenectomy (SPLNX) at 12 weeks of age and implanted with telemeters to measure BP. After 2 weeks, kidneys were harvested for flow cytometric analysis of T cells. Splenectomy increased BP in both sexes after 2 weeks. Renal Tregs decreased in both sexes after splenectomy, abolishing the sex differences in renal Tregs. In conclusion, splenic Tregs were comparable in male and female SHRs, suggesting that sex differences in renal Tregs is due to differences in renal Treg recruitment, not Treg production.
Combination of Comorbidities as a Reference Standard for Evaluating Auditory Processing Disorder: Response to the Letter to the Editor From Schow et al. (2021)
Authors: Ahmmed Ansar U. 
Published: September 2021

Purpose:Concerns expressed by Schow et al. (2021) around the evidence-based diagnostic criteria suggested by Ahmmed (2021a) are addressed here. The use of combination of comorbidities as a reference standard for evaluating auditory processing tests is a valid strategy, consistent with the Research Domain Criteria framework from the National Institute of Mental Health as well as the Standards for Reporting of Diagnostic Accuracy Studies. The correlations between auditory processing tests and some comorbidities in Ahmmed (2021a) were significant atp< .01. The low sensitivity and specificity reported was not related to the principle of using comorbidities as a reference standard but due to the choice of comorbidities combined in the reference standard. Ahmmed (2021a) suggested the option of inclusion of other comorbidities in addition to language impairment and impaired manual dexterity in the reference standard. Visual processing impairment could be considered as the additional comorbidity to improve sensitivity and specificity of the approach suggested by Ahmmed (2021a).
Effects of a Systematic Augmentative and Alternative Communication Intervention Using a Speech-Generating Device on Multistep Requesting and Generic Small Talk for Children With Severe Autism Spectrum Disorder
Authors: Chavers Tiffany N. , Morris Madison , Schlosser Ralf W. , Koul Rajinder 
Published: September 2021

Purpose
The purpose of this study was to determine the effects of augmentative and alternative communication (AAC) intervention using a speech-generating device (SGD) on acquisition, maintenance, and generalization of multistep requesting and generic small talk in three children with severe autism spectrum disorder (ASD) between the ages of 7 and 13 years.

Method
A multiple-baseline design across participants combined with a posttreatment multiple-generalization-probe design was used to assess acquisition, generalization, and maintenance of target communicative behaviors with the experimenter and the participants' familiar communication partners (FCPs). Intervention was composed of systematic instruction in the use of an SGD using least-to-most prompting, constant time delay, error correction, and reinforcement.

Results
Visual analysis established a strong functional relationship between the independent variable and the two dependent variables (i.e., requesting preferred activities, engaging in generic small talk) for all three participants. Effect size indicator analyses corroborated these findings, indicating strong effects for performing multistep requesting and medium effects for engaging in generic small talk. All participants were able to generalize the acquired communicative behaviors to request new and untrained snacks and activities and engage in generic small talk with FCPs who were not part of the training. Maintenance of acquired communicative behaviors was demonstrated 3 weeks post completion of intervention.

Conclusion
This study provides preliminary evidence that AAC intervention using an SGD and incorporating least-to-most prompting, constant time delay, error correction, and reinforcement is effective in terms of multistep requesting and generic small talk behaviors in children with severe ASD.

Supplemental Material

https://doi.org/10.23641/asha.16663630
Speech Development Between 30 and 119 Months in Typical Children II: Articulation Rate Growth Curves
Authors: Mahr Tristan J. , Soriano Jennifer U. , Rathouz Paul J. , Hustad Katherine C. 
Published: September 2021

Purpose
We aimed to develop normative growth curves for articulation rate during sentence repetition for typically developing children. Our primary goal was the development of quantile/percentile growth curves so that typical variation in articulation rate with age could be estimated. We also estimated when children became adultlike in their articulation rate, and we examined the contributions of age and utterance length to articulation rate.

Method
This cross-sectional study involved collection of in-person speech samples from 570 typically developing children (297 girls; 273 boys) who passed speech, language, and hearing screening measures. Pauses greater than 150 ms in duration were removed from the samples, and articulation rate was measured in syllables per second (sps).

Results
Articulation rate reliably increased with age and utterance length. Rate in all key percentiles increased with age. The median rate (50th percentile) increased from 2.7 sps at 36 months to 3.3 sps at 96 months. The 5th percentile increased from 2.3 to 3.1 sps over the same age range. Using 3.2 sps as a benchmark for adultlike speech, we found the 25th, 50th, and 75th percentiles reached adultlike rates at 99, 75, and 53 months, respectively.

Conclusions
Articulation rate increases from early childhood into middle childhood, and it is generally adultlike by 10 years of age. Variability in articulation rate among typical children was substantial. Implications for prior research and for clinical usage are discussed.
Service-Learning in Audiology: A Systematic Review
Authors: Ronney Alexis , Kirby Benjamin J. 
Published: September 2021

Purpose
Service-learning has the potential to improve student outcomes by providing students opportunities to apply their knowledge and skills in real-world contexts and is well suited to graduate education in communication sciences and disorders. However, relatively few service-learning studies in the literature focus on audiology, and the range of outcomes specific to audiology service-learning has not yet been characterized in a systematic way. The purpose of this critical review was to characterize the impact of service-learning on audiology students and clients/patients as evidenced by reflection activities and outcome measures, as well as to describe the common challenges and best practices in the available literature that may inform future research on service-learning in the field.

Method
A systematic search of the literature using multiple databases was completed according to standard guidelines. The impact of each study was evaluated using a standard scale of training efficacy. Study methods, including reflection activities and outcome measures, were recorded.

Results
Nine peer-reviewed studies on service-learning in audiology were selected. Six of the nine studies reported changes in student attitudes or awareness related to issues of clinical practice; five of the nine studies reported improvements in student knowledge/skills.

Conclusions
Overall, results of the review indicated benefits of service-learning to student clinicians. However, evidence for transference of service-learning benefits to organizational or departmental practice and benefit to patients/clients was lacking. Methodological limitations in the measurement of outcomes in prior works complicated evaluation of their impact; best practices were identified and synthesized for use in future research on audiology service-learning experiences.
Fundamentals of Epidemiology for the Audiologist
Authors: Torre Peter , Reavis Kelly M. 
Published: September 2021

Purpose
Epidemiology is the study of the distribution and determinants of disease and other health-related events in populations. An understanding of epidemiology among audiologists is important for ear and hearing health care practice. This tutorial presents an overview of the fundamental concepts of epidemiology for the practicing audiologist and audiology students.

Method

The authors provide an overview of epidemiology and focus on its applicability to audiology. The most common epidemiologic study designs, measures of occurrence, and measures of association are highlighted and discussed. Concepts related to
p
values, confidence intervals, confounding, and bias are introduced. Finally, the authors discuss screening as a means to control adverse hearing health outcomes.

Conclusions
Epidemiologic approaches are of value to the audiologist involved in the evidence-based decision processes of planning, monitoring, and treating individuals with ear and hearing problems. For audiologists to make practice recommendations based on epidemiologic data, they need insight into epidemiologic study design and interpretation of data from these studies. Understanding the fundamentals of epidemiology and applying epidemiologic principles to the clinical practice of audiology can increase the quality of care individuals receive.
Coherent integration and detection algorithm for hypersonic target based on modified pulse compression and Keystone transform
Authors: Yu Wenchao , Lu Xingyu , Su Weimin , Gu Hong , Yang Jianchao 
Published: September 2021

AbstractThis letter considers the coherent integration and detection for hypersonic target in the first‐order approximate (FOA) echo model. The proposed algorithm first accomplishes the modified pulse compression utilising the designed reference signal, then conducts the Keystone transform (KT) based coherent integration method to detect the target. Compared with the existing methods which model the received signal without considering the target's intrapulse motion, the proposed method has a lower modeling error and can maintain good noise robustness for weak hypersonic target detection. Experimental results are given to show the effectiveness of the proposed method.