bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scoping review of initiation criteria for inhaled nitric oxide in preterm infants (born <34 weeks) after 7 days of age
Authors: Kato Shin , Minamitani Yohei , Hosokawa Miku , Nakashima Toshinori , Iwatani Sota , Hirata Katsuya , Oda Arata , Hanita Takushi , Miyata Masafumi , Namba Fumihiko , Ochiai Masayuki , Nakao Atsushi , Yoshimoto Seiji , Suzuki Daichi , Ota Erika , Nakanishi Hidehiko 
Published: December 2024

ObjectivesInhaled nitric oxide (iNO) is a known treatment for pulmonary hypertension (PH) associated with bronchopulmonary dysplasia in preterm infants after 7 days of age (postacute phase). However, a consensus regarding the optimal criteria for initiating iNO therapy in this population in the postacute phase is currently lacking. This study, therefore, aimed to identify the criteria for initiating iNO therapy, alongside the associated clinical and echocardiographic findings, in this population.DesignWe performed a scoping review using the population-concept-context framework following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.Data sourcesPubMed, Embase and the Japanese database ‘Ichushi’ were systematically searched for relevant articles published between January 2003 and August 2023.Eligibility criteriaThis study included randomised controlled trials, prospective and retrospective cohort studies, case–control studies and case series on iNO therapy in the postacute phase for preterm infants born before 34 gestational weeks, written in English or Japanese.Data extraction and synthesisData screening, extraction and charting were performed independently, with the characteristics and findings of the included studies subsequently summarised.ResultsWe included 10 reports that analysed the data from 10 separate studies. The use of iNO therapy was categorised as prophylactic and rescue purposes. While randomised controlled trials (RCTs) and retrospective analyses indicated the safety of iNO during the postacute phase, the latter highlighted poor prognoses associated with severe cases requiring rescue iNO therapy. Additionally, although echocardiography is currently the primary diagnostic tool for identifying PH in preterm infants, standardised diagnostic criteria are lacking. Further, reports of complications and side effects associated with iNO are rare.ConclusionOur exploration of the initiation criteria for iNO revealed that definitive guidelines have not been established. Nonetheless, iNO administration during the postacute phase appeared to be safe and devoid of complications.Trial registration numberUMIN000051498.
Treating shock with norepinephrine administered in midline catheters in an intermediary care unit: a retrospective cohort study
Authors: Karlsson Hanna , Afrasiabi Ajnaz , Ohlsson Marcus , Månsson Viktor , Hartman Hannes , Torisson Gustav 
Published: December 2024

ObjectivesA rising incidence of septic shock as well as recommendations for early vasopressor initiation has increased the number of patients eligible for norepinephrine (NE). Traditionally, NE has been administered through central lines, in intensive care units, due to the risk of extravasation in peripheral lines. The aim of the current study is to determine the rate of complications and patient outcomes when NE is administered through midline catheters (MCs) in intermediary care units (IMCUs).DesignRetrospective cohort study.SettingThree IMCUs in southern SwedenParticipantsPatients with septic shock who received NE through a MC from September 2020 through March 2023.Primary and secondary outcome measuresThe primary outcome was a major complication to treatment, defined as extravasation of NE, catheter-associated venous thromboembolism and catheter-associated bloodstream infection (BSI). Secondary outcomes included patient outcomes after intermediary care (either deceased, discharged to regular ward care or intensive care) and the need for additional central lines.ResultsOf 474 eligible patients, 472 were included, with a median (IQR) age of 73.5 (65–80) years, with 281 (60%) men. The median (IQR) duration of NE infusion was 21 (9–38) hours, with a median (IQR) dosage of 0.12 (0.08–0.20) µg/kg/min. Major complications occurred in 12 cases (2.5%), with one suspected extravasation, seven thromboembolic events and four catheter-related BSIs. After intermediary care, 334 patients (71%) were discharged to regular ward care, 66 patients (14%) were escalated to intensive care and 72 (15%) died in intermediary care, of whom 69 had a documented ceiling of care decision. 100 patients (21%) received a central line.ConclusionNE administration in MCs was associated with a low rate of short-term complications and could decrease the need for central lines. MCs can enable the initial management of circulatory failure outside intensive care, but more studies are needed to determine the long-term value of IMCUs.Trial registration numberNCT06121115.
Recognising the heterogeneity of Indigenous Peoples during the COVID-19 pandemic: a scoping review across Canada, Australia, New Zealand and the USA
Authors: Lyeo Joonsoo Sean , Liberda Eric N , Ahmed Fatima , Charania Nadia A , Moriarity Robert J , Tsuji Leonard J , White Jerry P , Zuk Aleksandra M , Spence Nicholas D 
Published: December 2024

ObjectivesThe COVID-19 pandemic has had a disproportionate impact on the health of Indigenous Peoples in Canada, Australia, New Zealand and the USA, as reflected in the growing literature. However, Indigenous Peoples are often homogenised, with key differences often overlooked, failing to capture the complexity of issues and may lead to suboptimal public health policy-making. The objective of this review was to assess the extent to which the heterogeneity of the Indigenous Peoples in Canada, Australia, New Zealand and the USA has been reflected in COVID-19 research.DesignThis study took the form of a scoping review.Data sourcesMedline, Embase, CINAHL and Web of Science were searched for studies investigating COVID-19 pandemic outcomes among Indigenous Peoples in Canada, Australia, New Zealand and the USA. The search dates included January 2019 to January 2024.Eligibility criteriaAll citations yielded by this search were subjected to title and abstract screening, full-text review and data extraction. We included original, peer-reviewed research investigating COVID-19-related outcomes among Indigenous Peoples in Canada, Australia, New Zealand or the USA.Data extraction and synthesisData extraction was conducted as an iterative process, reaching consensus between two of the study authors. All included studies were analysed through a combination of quantitative descriptive summary and qualitative thematic analysis.ResultsOf the 9795 citations found by the initial search, 428 citations were deemed eligible for inclusion. Of these citations: 72.9% compared Indigenous participants to non-Indigenous participants; 10.0% aggregated Indigenous and non-white participants; and 17.1% provided findings for Indigenous participants exclusively.ConclusionsBy overlooking the heterogeneity that exists among Indigenous Peoples in Canada, Australia, New Zealand and the USA, researchers and policy-makers run the risk of masking inequities and the unique needs of groups of Indigenous Peoples. This may lead to inefficient policy recommendations and unintentionally perpetuate health disparities during public health crises.
Long-term exposure to multiple air pollutants and risk of Parkinson’s disease: a population-based multipollutant model study
Authors: Chen Szu-Ju , Pan Shih-Chun , Wu Chih-Da , Li Hsun , Guo Yue Leon , Lin Chin-Hsien 
Published: December 2024

BackgroundRecent evidence suggests brain-first Parkinson’s disease (PD) may start from the olfactory system, indicating potential inhalational exposure to causal agents. We investigated the impact of long-term exposure to various air pollutants on PD incidence using both single- and multi-pollutant models to account for interactions between pollutants.MethodsThis retrospective population study used data from Taiwan’s National Health Insurance Research Database (2006 and 2018) and included individuals aged 40–65 without PD. Personal exposure levels to various air pollutants, including PM2.5, PM10, NO2, O3, SO2and CO, were calculated using the hybrid Kriging/land-use regression method. Cox regression models were used to analyse the association between pollutants and PD incidence, adjusting for covariates.ResultsA total of 5 113 322 individuals without PD (mean age 50.1±6.9 years, 47.3% men) were followed for an average of 11.2±2.4 years, during which 20 694 incident cases of PD were identified. In the single-pollutant model, exposure to PM2.5(HR 2.65 (95% CI 2.59 to 2.72)), PM10(HR 3.13 (3.04 to 3.22)), NO2(HR 1.74 (1.68 to 1.80)) and SO2(HR 1.68 (1.65 to 1.71)) was associated with an increased risk of PD. These associations remained robust in the multipollutant model. A positive association between exposure to O3and an increased risk of PD (HR 1.29 (1.25–1.33)) was observed after adjusting for co-pollutants.ConclusionsThis nationwide cohort study employing multiple-pollutant models for considering the interaction effects revealed an association between exposure to multiple air pollutants and the risk of PD, emphasising the need for early prevention strategies.
Stability of evolving cluster of stars and exotic matter
Authors: Shahid Wasee , Manzoor Rubab , Mumtaz Saadia , Mardan Syed Ali , Malik Adnan 
Published: December 2024

Abstract
This paper discusses the phenomenon of evolving spherically symmetric cluster of stars in the presence of an exotic matter. To discuss evolutionary mechanism, we use the Starobinsky model of f(R) gravity as exotic matter and the structure scalars as evolutional parameters. We study various evolution modes such as isotropic pressure, quasi-homologous evolution, density homogeneity, and geodesic nature. The stability of homogeneous density of baryonic and non-baryonic matter is discussed using dissipation, tidal forces, anisotropic pressures, expansion and shear-effects. It is observed that the dark matter has remarkable impact on the evolutionary changes. Also, it is shown that the dissipation factor produces density inhomogeneity in expanding clusters with shear effects. We observe that high curvature geometry enhances quasi-homologous evolution in the presence of shear. We use star Her X-1 as test star to discuss physical behavior of Starobinsky model. It is found that the density of dark matter overcomes the density of matter for large values of dark matter parameter n.
Storage Abstractions for SSDs: The Past, Present, and Future
Authors: Zhang Xiangqun , Bhimani Janki , Pei Shuyi , Lee Eunji , Lee Sungjin , Seong Yoon Jae , Kim Eui Jin , Choi Changho , Nam Eyee Hyun , Choi Jongmoo , Kim Bryan S. 
Published: December 2024

This article traces the evolution of SSD (solid-state drive) interfaces, examining the transition from the block storage paradigm inherited from hard disk drives to SSD-specific standards customized to flash memory. Early SSDs conformed to the block abstraction for compatibility with the existing software storage stack, but studies and deployments show that this limits the performance potential for SSDs. As a result, new SSD-specific interface standards emerged to not only capitalize on the low latency and abundant internal parallelism of SSDs, but also include new command sets that diverge from the longstanding block abstraction.
We first describe flash memory technology in the context of the block storage abstraction and the components within an SSD that provide the block storage illusion. We then describe the genealogy and relationships among academic research and industry standardization efforts for SSDs, along with some of their rise and fall in popularity. We classify these works into four evolving branches: (1) extending block abstraction with host-SSD hints/directives; (2) enhancing host-level control over SSDs; (3) offloading host-level management to SSDs; and (4) making SSDs byte-addressable. By dissecting these trajectories, the article also sheds light on the emerging challenges and opportunities, providing a roadmap for future research and development in SSD technologies.
Bifurcation in a G0 Model of Hematological Stem Cells With Delay
Authors: Suqi Ma , Hogan S. J. 
Published: December 2024

The periodical dynamics of a G0 cell cycle model of pluripotential stem cells is analyzed by DDE‐Biftool software. The cell cycle model is impressed by modeling the optional choice of Hill function, which is benefited by Fourier transformation. The cell cycle is based on DDEs with distributed time delay, in which the kernel function is denoted by Gamma‐distribution expression. Hopf bifurcation of the linear version of the cell cycle model with distribution time delay is analyzed analytically. The periodical solution continuation is simulated by the artificial handbook of DDE‐Biftool software. With the discrete time delay, the complex behavior of adding‐period bifurcation and period‐doubling bifurcation are simulated. With distribution time delay, the continuation work of the homoclinic solution is done, and the homoclinic bifurcation line crosses the generalized Hopf point nearly.JEL Classification: 34C25, 34K18, 37G15
Exploring the Research Focus of RNA‐Binding Proteins in Trauma and Burns
Authors: Xie Sujie , Liu Yifan , Zhang Wei , Lu Jianyu , Tong Xirui , Huang Jie , Zhu Yushu , Wu Minjuan , Guo Xinya , Sun Hanlin , Gu Minyi , Jiang Luofeng , Xian Shuyuan , Huang Runzhi , Xia Zhaofan , Ji Shizhao 
Published: December 2024

Background: Trauma and burns are leading causes of death and significant global health concerns. RNA‐binding proteins (RBPs) play a crucial role in post‐transcriptional gene regulation, influencing various biological processes of cellular RNAs. This study aims to review the emerging trends and key areas of research on RBPs in the context of trauma and burns.Methods: A series of relevant articles were manually reviewed, and scientific publications on RBPs related to trauma and burns were retrieved from the Web of Science Core Collection (WoSCC) on May 19, 2024. Bibliometric analysis was performed using R‐bibliometrix, VOSviewer, and CiteSpace. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines to conduct the meta‐analysis, followed by a comprehensive review of the selected papers.Results: A total of 539 publications were identified from 2000 to 2024. China was the most productive and collaborative country, with Zhang Y being the most prolific author and PLoS One being the leading publication source. Keyword analysis revealed four distinct clusters. The thematic analysis identified eight key topics, including “RNA‐binding proteins,” “traumatic brain injury,” and “inflammation.” Four studies involving 5.976 patients were included in the final meta‐analysis, which indicated a correlation between RBP expression levels and poor prognosis in traumatic brain injury (TBI).Conclusion: Our findings provide valuable insights into the developing trends and key areas of research on RBPs in trauma and burns. Notably, we identified two primary hotspots: RBPs in the pathophysiological mechanisms of various traumatic injuries and RBPs in the processes of cutaneous wound healing. This rapidly evolving field offers significant reference points for scientific researchers and clinical practitioners.
Genomic Profiling Reveals SMARCA4 Mutations Are Associated with Shorter Overall and Intracranial Progression-Free Survival in Patients with Melanoma Brain Metastases
Authors: Fischer Grant M. , Lamba Nayan , Vogelzang Jayne , Aizer Ayal , Ligon Keith L. 
Published: December 2024

Abstract

Purpose:
Melanoma brain metastases (MBM) are a common and lethal complication of metastatic melanoma. Despite improvements in treatments, subsets of patients with MBM experience rapid clinical decline, and currently, few prognostic biomarkers have been identified. An improved understanding of the molecular features specifically associated with MBM overall survival (OS) and intracranial progression-free survival (PFS) could facilitate the development of more effective clinical management strategies.

Experimental Design:
We established an initial cohort of 102 MBMs, 970 unmatched melanoma extracranial metastases (ECM), and 569 unmatched melanoma primaries with available targeted exome sequencing data covering 182 genes and a validation cohort of 50 MBMs with SMARCA4 genomically profiled. Kaplan–Meier analysis, log-rank test, and Cox proportional hazards model were used to evaluate associations between pathogenic genomic alterations and OS and intracranial PFS. We evaluated 14 MBMs and 19 ECMs with paired RNA sequencing and whole-exome sequencing data to identify genotype–transcriptome correlations.

Results:
Of 43 genes significantly mutated among MBMs, only pathogenic mutations in SMARCA4 significantly associated with shorter OS and intracranial PFS on univariable and multivariable analyses in patients with MBM but not from first ECM or primary tumor diagnosis. SMARCA4 mutations significantly associated with enrichment of oxidative phosphorylation and depletion of immune signaling gene sets.

Conclusions:
Pathogenic SMARCA4 mutations independently predict an association with shorter OS and intracranial PFS in patients with MBM and associate with expression of pathways known to mediate melanoma virulence. These findings add to our understanding of MBM pathogenesis and suggest their potential use as prognostic biomarkers in patients with MBM and possible therapeutic opportunities.
Triple Combination of MEK, BET, and CDK Inhibitors Significantly Reduces Human Malignant Peripheral Nerve Sheath Tumors in Mouse Models
Authors: Ortega-Bertran Sara , Fernández-Rodríguez Juana , Magallón-Lorenz Miriam , Zhang Xiaohu , Creus-Bachiller Edgar , Diazgranados Adriana Paola , Uriarte-Arrazola Itziar , Mazuelas Helena , Blanco Ignacio , Valverde Claudia , Carrió Meritxell , Villanueva Alberto , De Raedt Thomas , Romagosa Cleofé , Gel Bernat , Salvador Héctor , Ferrer Marc , Lázaro Conxi , Serra Eduard 
Published: December 2024

Abstract

Purpose:
Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft-tissue sarcoma that develops sporadically or in patients with neurofibromatosis type 1 (NF1). Its development is marked by the inactivation of specific tumor suppressor genes (TSG): NF1, CDKN2A, and SUZ12/EED (polycomb repressor complex 2). Each TSG loss can be targeted by particular drug inhibitors, and we aimed to systematically combine these inhibitors, guided by TSG inactivation status, to test their precision medicine potential for MPNSTs.

Experimental Design:
We performed a high-throughput screening in 3 MPNST cell lines testing 14 MEK inhibitors (MEKi), 11 cyclin-dependent kinase 4/6 inhibitors (CDKi), and 3 bromodomain inhibitors (BETi) as single agents and 147 pairwise co-treatments. Best combinations were validated in nine MPNST cell lines, and three were tested in one sporadic and one NF1-associated patient-derived orthotopic xenograft (PDOX) MPNST mouse model. A final combination of the three inhibitor classes was tested in the same PDOX models.

Results:
A high degree of redundancy was observed in the effect of compounds of the same inhibitory class, individually or in combination, and responses matched with TSG inactivation status. The MEKi–BETi (ARRY-162 + I-BET151) co-treatment triggered a reduction in half of the NF1-related MPNST PDOXs and all the sporadic tumors, reaching 65% reduction in tumor volume in the latter. Remarkably, this reduction was further increased in both models combining the three inhibitor classes, reaching 85% shrinkage on average in the sporadic MPNST.

Conclusions:
Our results strongly support precision therapies for MPNSTs guided by TSG inactivation status. MEKi–BETi CDKi triple treatment elicits a significant reduction of human MPNST PDOXs.
Cross-talk between WNT Signaling and Ferroptosis in Cancer
Authors: Wang Zheng , Zhang Zhixiang , Yue Yunhui , Hou Yifan , Cao Yujia , Guo Changsheng , Nie Xiaobo , Hou Junqing 
Published: December 2024

Abstract
Cancer remains one of the most formidable challenges in the medical field in this century, largely because of its poorly understood pathogenesis. Fortunately, recent advancements in the understanding of cancer pathogenesis have helped identify more therapeutic targets for improved treatment outcomes. The WNT signaling pathways are highly conserved cascades that participate in diverse physiologic processes, such as embryonic development, tissue homeostasis, and tissue regeneration. Ferroptosis, a unique iron-dependent form of cell death that is distinct from apoptosis, is driven by lipid peroxidation and excessive reactive oxygen species production. Emerging evidence shows that the dysregulation of WNT signaling pathways and ferroptosis, as well as their intricate cross-talk, plays crucial roles in cancer progression and therapeutic resistance, indicating their potential as targets for cancer therapies. This review provides a comprehensive overview of the current understanding of the cross-talk between WNT signaling pathways and ferroptosis in the pathogenesis and progression of cancer, with a specific focus on the regulatory role of the canonical WNT cascade in cancer-related ferroptosis. In addition, we discuss the pharmacologic mechanisms of current strategies that inhibit canonical WNT signaling and/or induce ferroptosis in cancer treatment. We propose that combining canonical WNT pathway inhibitors and ferroptosis inducers with current therapies represents a promising therapeutic strategy for personalized cancer treatment.
Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Authors: Nishino Jinsuke , Hu Wenhuo , Kishtagari Ashwin , Shen Bo , Gao Xiang , Blackman Caroline M. , Kassim Adetola , Marneni Naimisha , Cherukuri Abhisar V. , Vittrup Russell , Kalkan Fatma N. , Shah Rahul , Ahn Chul , Gao Ang , Ahmedrabie Abeer , Collins Robert H. , Zeidan Amer M. , Bidikian Aram , Gowda Lohith , Shaffer Brian C. , Madanat Yazan F. , Zhao Zhiyu , Chung Stephen S. , Morrison Sean J. 
Published: December 2024

Abstract
Peripheral nerves promote mouse bone marrow regeneration by activating β2- and β3-adrenergic receptor signaling, raising the possibility that nonselective β-blockers could inhibit engraftment after hematopoietic cell transplants (HCT). We observed no effect of β-blockers on steady-state mouse hematopoiesis. However, mice treated with a nonselective β-blocker (carvedilol), but not a β1-selective inhibitor (metoprolol), exhibited impaired hematopoietic regeneration after syngeneic or allogeneic HCTs. At two institutions, patients who received nonselective, but not β1-selective, β-blockers after allogeneic HCT exhibited delayed platelet engraftment and reduced survival. This was particularly observed in patients who received posttransplant chemotherapy for graft-versus-host disease prophylaxis, which also accentuated the inhibitory effect of carvedilol on engraftment in mice. In patients who received autologous HCTs, nonselective β-blockers were associated with little or no delay in engraftment. The inhibitory effect of nonselective β-blockers after allogeneic HCT was overcome by transplanting larger doses of hematopoietic cells.

Significance:
Patients who receive allogeneic HCTs followed by posttransplant chemotherapy for graft-versus-host disease prophylaxis may be at risk of delayed engraftment and increased mortality if administered nonselective β-blockers after transplantation. Transient discontinuation of nonselective β-blockers or transitioning to β1-selective inhibitors after HCT may accelerate engraftment and improve clinical outcomes.