bluuebunny/crossref_metadata_2025_split huggingface dataset:
The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects
Authors: Uthaug Malin Vedøy , Davis Alan K , Haas Trevor Forrest , Davis Dawn , Dolan Sean B , Lancelotta Rafael , Timmermann Christopher , Ramaekers Johannes G 
Published: May 2021

Background: Mescaline is a naturally occurring psychoactive phenethylamine found in several cacti and historically used ceremonially by Indigenous and Latin American populations. Broader recognition of its possible therapeutic value in Western science began in the 1950s; however, knowledge of the safety profile of mescaline and the extent of its use remains limited. The primary aim of this study is to examine the epidemiology of mescaline use among English-speaking adults. Methods: About 452 respondents completed a web-based survey designed to assess their previous experience with mescaline (subjective effects, outcome measures, and mescaline type used). Results: Most respondents reported that they had consumed mescaline infrequently (⩽once/year), for spiritual exploration or to connect with nature (74%). A small number of respondents reported drug craving/desire (9%), whereas very few reported legal (1%), or psychological problems (1%) related to its use, and none reported seeking any medical attention. Overall, respondents rated the acute mystical-type effects as “ moderate,” ego-dissolution and psychological insight effects as “ slight,” and challenging effects as “ very slight.” Most respondents reported that they used Peyote and San Pedro in their most memorable mescaline experience. Overall, the intensity of acute mescaline effects did not differ between mescaline types. About 50% of the sample reported having a psychiatric condition (i.e. depression, anxiety, etc.), and most (>67%) reported improvements in these conditions following their most memorable experience with mescaline. Conclusion: Findings indicate that the mescaline in any form may produce a psychedelic experience that is associated with the spiritual significance and improvements in the mental health with low potential for abuse.
The Multifocal Approach to Sharing in Shared Decision Making: A Critical Appraisal of the MAPPIN’SDM
Authors: Forner David , Noel Christopher W. , Boland Laura , Pieterse Arwen H. , Borkhoff Cornelia M. , Hong Paul 
Published: May 2021

Objective Shared decision making integrates health care provider expertise with patient values and preferences. The MAPPIN’SDM is a recently developed measurement instrument that incorporates physician, patient, and observer perspectives during medical consultations. This review sought to critically appraise the development, sensibility, reliability, and validity of the MAPPIN’SDM and to determine in which settings it has been used. Methods This critical appraisal was performed through a targeted review of the literature. Articles outlining the development or measurement property assessment of the MAPPIN’SDM or that used the instrument for predictor or outcome purposes were identified. Results Thirteen studies were included. The MAPPIN’SDM was developed by both adapting and building on previous shared decision making measurement instruments, as well as through creation of novel items. Content validity, face validity, and item quality of the MAPPIN’SDM are adequate. Internal consistency ranged from 0.91 to 0.94 and agreement statistics from 0.41 to 0.92. The MAPPIN’SDM has been evaluated in several populations and settings, ranging from chronic disease to acute oncological settings. Limitations include high reading levels required for self-administered patient questionnaires and the small number of studies that have employed the instrument to date. Conclusion The MAPPIN’SDM generally shows adequate development, sensibility, reliability, and validity in preliminary testing and holds promise for shared decision making research integrating multiple perspectives. Further research is needed to develop its use in other patient populations and to assess patient understanding of complex item wording.
Intravoxel incoherent motion magnetic resonance imaging in predicting IDH1 gene mutations in high-grade gliomas
Authors: Wang Chaochao , Dong Haibo 
Published: May 2021

Background Intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) has been applied to gliomas; however, the relationships between its parameters and isocitrate dehydrogenase 1 (IDH1) mutations in gliomas remain to be investigated. Purpose To investigate the value of IVIM in predicting IDH1 mutations in high-grade gliomas before surgery. Material and Methods A total of 72 patients with pathologically confirmed high-grade gliomas underwent conventional brain MRI and IVIM from September 2016 to May 2020. Among them, 22 cases were IDH1 mutant and 50 cases were IDH1 wild type. The independent samples t test (normal distribution and homogeneity of variance) or Mann–Whitney rank-sum test (non-normal distribution or heterogeneity of variance) was conducted, and receiver operating characteristic curves were generated to determine parameters for distinguishing IDH1-mutated from IDH1 wild-type high-grade gliomas. These parameters included apparent diffusion coefficient (ADC), true diffusivity (D), pseudo-diffusivity (D*), and perfusion fraction ( f). Results ADC, D, and f were significantly higher in IDH1-mutated gliomas than in IDH1 wild-type gliomas ( P < 0.05 for all). There was no significant difference in the D* value between the two groups ( P = 0.053). The areas under the curve of ADC, D, and f in predicting IDH1 mutations in gliomas were 0.798, 0.810, and 0.823, respectively. The specificity of ADC was highest (80.0%), and the sensitivity of the f value was the highest (100.0%). Conclusion IVIM can be used for the quantitative prediction of IDH1 mutations in high-grade gliomas before surgery, and the f value is the most effective.
Perioperative safety and short-term efficacy of functional minimally invasive esophagectomy
Authors: Liu Huibing , Jin Defeng , Wang Qian , Cui Zhaoqing , Zhang Luchang , Wei Yutao 
Published: May 2021

Background Standard minimally invasive McKeown three-field esophagectomy (SMIE) results in high perioperative risk and poor postoperative quality of life owing to considerable surgical damage and numerous postoperative complications. We created a modified procedure, functional minimally invasive esophagectomy (FMIE), which preserves the azygos arch, bronchial artery, pulmonary branch of the vagus nerve, and the mediastinal pleura. Our aim was to evaluate the efficacy and safety of FMIE and to determine whether it has limited invasiveness. Methods Between 2018 and 2020, FMIE was performed for 48 patients who were compared with 76 SMIE cases; 44 paired cases were matched using propensity score matching. Results Operation time, extubation time, and postoperative hospital stay were significantly lower in the FMIE group. FMIE was also associated with fewer pulmonary infections. Postoperative drainage volume on postoperative day (POD) 1 and POD 2, and white blood cell counts on POD 2 and POD 4 were also significantly lower in the FMIE group. There was no statistically significant difference in the number of dissected lymph nodes, short-term recurrence, metastasis rates, or survival rate between the two groups. Conclusions FMIE is a less invasive procedure and may be a suitable alternative for lower and early middle esophageal carcinoma.
Subtotal intracapsular tonsillectomy may be the first choice for tonsillectomy in children
Authors: Wang Jie , Dang Pan-hong , Chang Huan-huan , Wang Zi-han 
Published: May 2021

Objective To investigate the effect and prognosis of subtotal intracapsular tonsillectomy. Methods All children (n=162) with tonsillar hypertrophy and chronic tonsillitis were randomly divided into two groups: tonsillectomy (n=75) and subtotal intracapsular tonsillectomy (n=87). Tonsillectomy: the tonsillar tissue was completely removed along with the tonsillar capsule. Subtotal intracapsular tonsillectomy: 80% to 90% of the tonsils and the complete epithelium of the tonsillar crypts were removed without damaging the tonsillar capsule. The Face, Legs, Activity, Cry, and Consolability (FLACC) and parents’ postoperative pain measure (PPPM) scales were used to evaluate postoperative pain, and the obstructive sleep apnea (OSA)-18 questionnaire was used to assess the children’s postoperative quality of life. The patients were followed-up for 2 years. Results 1. The FLACC and PPPM scales indicated that the children’s postoperative pain after subtotal intracapsular tonsillectomy was significantly less than that of children undergoing tonsillectomy. 2. The OSA-18 scale scores indicated that subtotal intracapsular tonsillectomy significantly improved the children’s quality of life. 3. Two years after subtotal intracapsular tonsillectomy, no patients required reoperation. Conclusion Subtotal intracapsular tonsillectomy may be the first choice for tonsillar hypertrophy and chronic tonsillitis patients.
Uncemented versus cemented arthroplasty after metal-on-metal total hip replacement in patients with femoral neck fractures: a retrospective study
Authors: Liu Wenlu , Lin Huanyi , Zeng Xianshang , Chen Meiji , Tang Weiwei , Zhou Ting , Yu Weiguang , Liu Qilong , Xu Guixing 
Published: May 2021

Objective To compare the clinical outcomes of primary metal-on-metal total hip replacement (MoM-TR) converted to uncemented total hip replacement (UTR) or cemented total hip replacement (CTR) in patients with femoral neck fractures (AO/OTA: 31B/C). Methods Patient data of 234 UTR or CTR revisions after primary MoM-TR failure from March 2007 to January 2018 were retrospectively identified. Clinical outcomes, including the Harris hip score (HHS) and key orthopaedic complications, were collected at 3, 6, and 12 months following conversion and every 12 months thereafter. Results The mean follow-up was 84.12 (67–100) months for UTR and 84.23 (66–101) months for CTR. At the last follow-up, the HHS was better in the CTR- than UTR-treated patients. Noteworthy dissimilarities were correspondingly detected in the key orthopaedic complication rates (16.1% for CTR vs. 47.4% for UTR). Statistically significant differences in specific orthopaedic complications were also detected in the re-revision rate (10.3% for UTR vs. 2.5% for CTR), prosthesis loosening rate (16.3% for UTR vs. 5.9% for CTR), and periprosthetic fracture rate (12.0% for UTR vs. 4.2% for CTR). Conclusion In the setting of revision of failed primary MoM-TR, CTR may demonstrate advantages over UTR in improving functional outcomes and reducing key orthopaedic complications.
Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles
Authors: Wang Hanbi , Tang Xian , Bukulmez Orhan , Deng Chengyan , Yu Qi , Zhou Yuanzheng , Sun Zhengyi , Zhen Jingran , Wang Xue , Liu Meizhi 
Published: May 2021

Objective This prospective study aimed to assess the effect of short-acting gonadotropin-releasing hormone agonist (GnRHa) administration on pregnancy outcomes in frozen–thawed embryo transfer (FET) cycles. Methods Patients who planned to have FET in Peking Union Medical College Hospital (China) were recruited for this study and randomly assigned into two groups. Patients in the experimental group (n = 460) received triptorelin acetate on the day of embryo transfer along with routine luteal support. Patients in the control group (n = 433) only received luteal support. One dose (0.1 mg) of a short-acting GnRHa was administered on the day of blastocyte transfer. The rates for clinical pregnancy, biochemical pregnancy, implantation, miscarriage, and ectopic pregnancy were compared between the groups. Results There were no significant differences in the number and quality of blastocytes transferred between the two groups. In the experimental and control groups, the clinical pregnancy rate was 56.3% and 50.58%, the biochemical pregnancy rate was 15.78% and 18.94%, and the median implantation rate was 39.98% and 38.01%, respectively, with no significant difference between the groups. Biochemical pregnancy and abortion and the ectopic pregnancy rate were not significantly different between the two groups. Conclusion In FET cycles, a GnRHa does not affect the pregnancy outcome.
Pathogen distribution and risk factors for urinary tract infection in infants and young children with retained double-J catheters
Authors: Wang Jianfeng , Cao Yu , Zhang Li , Liu Guoqing , Li Chunjing 
Published: May 2021

Objectives To investigate the pathogens and potential risk factors for urinary tract infection (UTI) in patients with retained double-J catheters (DJCs). Methods In total, 107 infants and young children with DJCs were included in this retrospective analysis. Patients were included in the infection group (n = 30) or non-infection group (n = 77), according to UTI presence or absence. The species and characteristics of pathogens were investigated, and the clinical features of the patients were recorded for further analysis. Results Gram-negative bacilli were the most common causative pathogens (69.2%), among which Escherichia coli was most frequent (38.5%). The second most common causative pathogens were Gram-positive cocci (28.2%), among which Enterococcus faecalis was most frequent (10.3%). UTIs among patients in this study were associated with the following factors: catheter retention (long-term) (odds ratio [OR] = 2.514, 95% confidence interval [CI] = 1.176–5.373), sex (male) (OR = 2.966, 95% CI = 1.032–8.529), DJC retention (long-term) (OR = 1.869, 95% CI = 1.194–2.926), and DJC number (unilateral) (OR = 0.309, 95% CI = 0.103–0.922). Conclusions Infants and young children with DJCs were likely to experience UTIs, mainly caused by Gram-negative bacilli. Long-term catheter retention or DJC retention, male sex, and bilateral DJC retention were risk factors for UTI.
Outcomes of late Kasai portoenterostomy in biliary atresia: a single-center experience
Authors: Khayat Ammar , Alamri Aisha M. , Saadah Omar I. 
Published: May 2021

Objectives To describe the clinical, histopathologic, and outcomes data for a cohort of patients with biliary atresia (BA), and to identify the factors affecting survival. Methods This was a cross-sectional study of all BA patients diagnosed between 1999 and 2017. Clinical, biochemical, imaging, and histopathologic data were analyzed, and Kaplan–Meier survival rates were compared to identify potential prognostic factors. Results We evaluated 23 patients. The median age at the Kasai procedure was 77 ± 34 days, and the median overall survival was 12.5 ± 65 months. Thirteen (56%) patients survived with their native livers, 3 (13%) received a transplant, and 6 died (26%) while awaiting a transplant. Cholangitis and the use of ursodeoxycholic acid were associated with longer survival, while impaired synthetic function was associated with shorter survival. Conclusions Most patients presented late for the Kasai procedure. The survival rate with the native liver was comparable to other cohorts. Therefore, clinicians are encouraged to refer for the Kasai procedure even with late presentation (between 60 and 90 days), provided there is no hepatic decompensation.
Expression of Torque and Its Effect on Various Biological Structures Caused by Varying Archwire Material: A 3D FEM Study
Authors: Kothari Ridhi , Gupta Seema , Bhambri Eenal , Ahuja Sachin , Bharadwaj Ankit 
Published: May 2021

Objective: Studying torque expression and biomechanical effects of various wires on giving palatal root torque, using finite element (FE) method (FEM). Conclusion: TMA wires are most favourable for torquing, in terms of torque expression and susceptibility to root resorption. Materials and Method: Geometric model of maxillary right central incisor was developed, using computed tomography (CT) scan. 0.022" × 0.028" Standard edgewise brackets and 10-mm-long stainless steel (SS), titanium molybdenum (TMA) and titanium niobium (TiNb) archwires of dimension 0.019" × 0.025" were modeled and a palatal root torque of 25 degrees was applied on all wires. The angular displacement of the crown and root and nodal displacement at the incisal edge and root apex in y and z axis were analyzed along with stresses on periodontal ligament (PDL), bone, cementum, enamel, and bracket. Results: Buccal crown and palatal root movement was seen, which was maximum for SS and least for TMA. Angular displacement was also highest for SS. Compressive stresses were concentrated at the bucco-cervical and linguo-apical regions in the PDL, cementum, and bone and tensile stresses were concentrated in the linguo-cervical regions. In the enamel, the bracket attachment site showed maximum stresses, and slot base showed higher values of stresses than wings. All stress values were highest for SS and least for TMA.
Measurement and Comparison of Bracket Transfer Accuracy With Different Indirect Bonding Techniques: An In Vitro Study
Authors: Rastogi Sonam , Goyal Manish , Kumar Mukesh , Shaha Kalpit Shitalkumar , Yadav Ekta , Kaur Amandeep 
Published: May 2021

Objective: To measure and compare bracket transfer accuracy of 3 indirect bonding (IDB) techniques. Material and Methods: Three IDB techniques were studied using polyvinyl siloxane (PVS) putty, vacuum-form (VF), and glue gun (GG). A total of 120 orthodontic stone models were fabricated with die stone, out of which bonding was done on 60 working models and transferred to other 60 patient models. One quadrant was selected for each technique. Digital photography was used to measure the mesiodistal ( X-axis), occlusogingival ( Y-axis), and faciolingual ( Z-axis) position of each bracket on the working and patient models. Results: All the 3 IDB techniques have a very good bracket transfer accuracy. On comparing individual planes, greatest accuracy was seen in GG on X-axis, VF on Y-axis, and VF/PVS on Z-axis. Points A and B were compared for bracket rotation and the mean differences were insignificant indicating that there was no significant amount of rotation in 3 IDB techniques. Conclusions: We can say that all 3 IDB techniques had a very high bracket transfer accuracy. Out of the 3 IDB techniques VF was the most accurate, whereas PVS was the least accurate technique. The selection of technique should be based on tray cost and fabrication time.
Study of environmental factors and quality of life in children with cerebral palsy based on international classification of functioning, disability and health
Authors: Rezaei Amin , Raji Parvin , Mousavi Seyedeh Tahmineh , Mahmoodian Mahmoud , Baghestani Ahmad Reza 
Published: May 2021

Introduction Identification of environmental barriers is an important factor for improving quality of life. The aim was to investigate the relationship between environmental factors and quality of life of children with cerebral palsy and to prioritize environmental factors affecting the quality of life. Method In this cross-sectional study, participants were children with cerebral palsy ( n = 67) 8–12 years. The European Child Environment Questionnaire and cerebral palsy quality of life questionnaire were used. In order to prioritize environmental codes, each of the items in the European Child Environment Questionnaire was linked to environmental codes of the cerebral palsy ICF Core Set. Data were analyzed using SPSS and Pearson correlation and regression tests. Results There was a significant negative relationship between quality of life and environmental barriers ( p < 0.05, r = −0.36). The European Child Environment Questionnaire covered 75% of the environmental codes of cerebral palsy ICF Core Set. Also, e5 (services, systems and policies) was identified as the main priority of environmental factors affecting the quality of life. Conclusion Occupational Therapists should devote part of the interventional plan to reduce environmental barriers. On the other hand, decision-making organizations have to make supportive laws to improve the physical environment of the home, community, school, and work.
Exploring how occupational therapists and physiotherapists evaluate rehabilitation potential of older people in acute care
Authors: Bradley Gemma , Baker Katherine , Bailey Catherine 
Published: May 2021

Introduction Evaluations of rehabilitation potential are an everyday occurrence, yet the concept is poorly understood and there is a lack of understanding about the reasoning process. This study aimed to explore how occupational therapists and physiotherapists evaluated the rehabilitation potential of older people following an acute hospital admission. Method Focused ethnography was utilised, primarily using observation, interviewing and review of records within one acute medical ward in a general hospital in the United Kingdom. Five patient participants gave consent for their episode of care to be studied, for interactions with professionals to be observed and for their clinical records to be reviewed. Three occupational therapists and two physiotherapists then participated in individual interviews. Findings Thematic analysis of data led to the identification of a four-stage reasoning process. The four stages are as follows: gathering baseline information; provision of curative and supportive interventions; provision and monitoring of rehabilitative interventions; the evaluation of rehabilitation potential and decision about the subsequent pathway. Conclusions The reasoning process illustrates the professional reasoning of occupational therapists and physiotherapists when evaluating rehabilitation potential for older adults in acute care. However, it also highlights vulnerabilities to professional reasoning which may contribute to subjectivity, inconsistency or risk to patients.
Occupational balance and quality of life in mothers of children with cerebral palsy
Authors: Günal Ayla , Pekçetin Serkan , Wagman Petra , Håkansson Carita , Kayıhan Hülya 
Published: May 2021

Introduction Occupational balance (OB) is an important concept in occupational therapy and is considered as an essential component of health and well-being. The aim of this study was to show differences in OB and quality of life (QoL) between mothers of children with cerebral palsy (CP) and typically developing children. Methods Thirty-six mothers of children with CP and 36 mothers of typically developing children participated in the study. The mothers’ OB was evaluated using the Turkish Occupational Balance Questionnaire-11 (OBQ11-T), and their QoL was evaluated with the Nottingham Health Profile (NHP). Results The OBQ11-T, total score, and the item ‘balance between obligatory and voluntary occupations’ score differed significantly between the groups ( p < 0.05). There were also significant differences in NHP’s aspects of emotional reaction, social isolation, and sleep scores between the groups ( p < 0.05). A negative correlation was detected between OBQ11-T total and NHP total scores in mothers of children with CP ( p < 0.01). Conclusion This study demonstrates that occupational therapists should pay attention to balance between obligatory and voluntary occupations to promote occupational balance. Also, QoL in mothers of children with CP should be evaluated. Therefore, occupational therapists should implement interventions to increase them when necessary for mothers of children with CP.