bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?
Authors: Carosso Andrea Roberto , EEKELEN Rik van , Revelli Alberto , Canosa Stefano , Mercaldo Noemi , Benedetto Chiara , Gennarelli Gianluca 
Published: September 2021

Abstract
BackgroundSeveral researches have investigated alternative markers related to ovarian responsiveness in order to better predict IVF outcomes, particularly in advanced reproductive aged women. The follicular output rate (FORT), the follicle-oocyte index (FOI) and the ovarian sensitivity index (OSI) are among the most promising. However, these three metrics have not been investigated as independent predictors of live birth in women of advanced reproductive age, neither have been compared to the two ‘component’ characteristics that were used to calculate them.MethodsA logistic regression model containing all relevant predictors of ovarian reserve or response was used to evaluate the potential of FORT, FOI and OSI as predictors of live birth. After, the non-linear associations between FORT, FOI and OSI and the probability of live birth was evaluated. Finally, we fitted multiple logistic regression models to compare whether FORT, FOI and OSI were more informative predictors than the two ‘components’ used to calculate them. Results590 couples received a total of 740 IVF cycles, after which 127 (17.5%) obtained a live birth. None of FORT, FOI and OSI showed a strength of association or a p-value even close to female age (Odds ratio for live birth (95% Confidence Interval) 1.00 (0.99-1.01), 1.00 (0.99-1.01), 0.98 (0.88-1.11) and 0.58 (0.48-0.72), respectively). The three models comparing FORT, FOI and OSI with the two ‘components’ used to calculate them were not more informative.Conclusion(s)In a population of women of advanced age with unexplained infertility, none of FORT, FOI and OSI were predictive of live birth and more predictive than the two ‘components’ characteristics that were used to calculate them. We suggest clinicians and researchers still to use female age as the most reliable predictor of an IVF treatment.Trial registrationretrospectively registered
Management of Paediatric Head Injuries in Sweden: A 5 National Cross-Sectional Survey
Authors: Wickbom Fredrik , Persson Linda , Olivecrona Zandra , Undén Johan 
Published: September 2021

Abstract
Background Previous studies have shown varying management of children with traumatic brain injury (TBI) in Sweden. Recently, new guidelines have been introduced which may have affected management of these patients. Methods Cross-sectional structured survey, containing different management domains, in Sweden during 2020, using an on-line survey system aiming to describe initial (first 24 hours) management of TBI in children. Data presented as descriptive analysis and comparisons with Fisher exact test when applicable. Results 56 hospitals of differing size were included in the analysis (response rate 93%). 76% used established guidelines. Children with TBI are predominately managed by inexperienced doctors (84%), primarily from non-paediatric specialities (75%). Most hospitals (75%) have the possibility to observe children with TBI and almost all have complete access to CT scans. In larger hospitals, it was more common for nurses to discharge patients without doctor assessment (p<0.001). Use of established guidelines and written observation routines has increased significantly since 2006 (p<0.001). Conclusions Management of children with TBI still varies in Sweden, although many aspects have significantly improved over the last 15 years. Most hospitals use established guidelines, utilise dose-reduction protocols for CT, use written observation routines and provide adequate information to patients/guardians at discharge.
Comparison of Sleep Quality Deterioration by Subgroup of Painful Temporomandibular Disorder Based on Diagnostic Criteria for Temporomandibular Disorders
Authors: Lee Yeon-Hee , Auh Q-Schick 
Published: September 2021

Abstract
This study investigated whether sleep deterioration in patients with painful temporomandibular disorder depends on the origin of pain, and also analyzed which clinical disease characteristics and whether psychological distress affected sleep quality. A total of 337 consecutive patients (215 women; mean age, 33.01 ± 13.01 years) with painful temporomandibular disorder (myalgia [n = 120], temporomandibular joint arthralgia [n = 62], mixed joint–muscle temporomandibular disorder pain [n = 155]) based on the diagnostic criteria for temporomandibular disorder were enrolled. They completed a battery of standardized reports on clinical sign and symptoms, and answered questions on sleep quality, excessive daytime sleepiness, and patients’ psychological status. The mean global Pittsburgh Sleep Quality Index scores were significantly higher in the mixed temporomandibular disorder pain group (6.97 ± 3.38) and myalgia group (6.40 ± 3.22) than in the arthralgia group (5.16 ± 2.94) (p = 0.001). Poor sleepers were significantly more prevalent in the mixed temporomandibular disorder pain group (76.8%) and myalgia group (71.7%) than in the arthralgia group (54.8%) (p = 0.006). The presence of psychological distress in the myalgia group (β = 1.236, p = 0.022), global severity index of the Symptom Checklist-90-Revised in the arthralgia group (β = 1.668, p = 0.008), and presence of headache (β = 1.631, p = 0.002) and self-reported sleep problems (β = 2.849, p < 0.001) in the mixed temporomandibular disorder pain group were associated with an increase in the Pittsburgh Sleep Quality Index score. Because there is a difference in sleep quality and influencing factors according to the pain source of painful temporomandibular disorder, and the complex interplay between sleep and pain can vary, sophisticated treatment is required for patients.
A Quest to Capture Latent Fabry’s Disease in a High-Risk Subpopulation of FMF.
Authors: Maller Tomer , Ben-Zvi Ilan , Lidar Merav , Livneh Avi 
Published: September 2021

Abstract
Background: Familial Mediterranean fever (FMF) is an autosomal recessive disease, associated with mutations in the Mediterranean fever gene (MEFV), and manifests with recurrent episodes of febrile serositis. Fabry’s disease (FD) is an X-linked lysosomal storage disease caused by mutations in the alpha- galactosidase A gene, and presents with a wide range of gastrointestinal, skin, vascular, renal and neurological manifestations. FMF and FD share similar manifestations, which may lead to misdiagnosis of one as the other; mostly FD is misdiagnosed as FMF. Moreover, various overlapping manifestations may stem from comorbidities, commonly coupled to FMF, as well as from colchicine adverse effects, which may add to the diagnostic confusion. Thus, we postulated that screening FMF for FD will lead to the identification of patients falsely diagnosed as FMF, or who suffer from FD that was previously missed.Methods: To find missed FD among FMF population, we performed chemical and genetic analyses for FD in blood samples obtained from a cohort of FMF patients followed in the specialized FMF center of our institution. To increase the likelihood of detecting patients with FD, we enriched the surveyed FMF population with patients exhibiting manifestations shared by patients with FD or who deviate from the typical FMF presentation.Results and conclusions: Of 172 surveyed FMF patients in a cohort derived from a clinic dedicated to FMF, none had FD. Thus, the postulation of increased odds for detecting FD in patients with FMF was not confirmed.
Knockdown of KCNQ1OT1 Alleviates the Activation of NLRP3 Inflammasome Through miR-17-5p/TXNIP Axis in Retinal Müller Cells
Authors: Liu Yu , Cao Guoping , Dong Lili , Li Lele , Dou Yuping , Xue Aihua , Chen Xiujuan , Sang Aimin , Zhu Manhui 
Published: September 2021

Abstract
Diabetic retinopathy (DR) is one of the most severe and common complications caused by diabetic mellites. Inhibiting NLRP3 inflammasome activation displays a crucial therapeutic value in DR. Studies have shown that KCNQ1OT1 plays a critical role in regulating NLRP3 inflammasome activation and participates in the pathogenesis of diabetic complications. The present study aims to explore the role, and the potential mechanism of KCNQ1OT1 in regulating the activation of NLRP3 inflammasome in DR. The expression of KCNQ1OT1 and the activation of NLRP3 inflammasome were increased in experimental DR models. KCNQ1OT1 knockdown alleviated NLRP3 inflammasome-associated molecules expression. In addition, KCNQ1OT1 was found to be localized mainly in the cytoplasm of Müller cells and facilitated TXNIP expression by acting as a miR-17-5p sponge. KCNQ1OT1 promoted the activation of NLRP3 inflammasome through miR-17-5p/TXNIP axis. Moreover, the clinical samples of patients with DR showed that the expression of KCNQ1OT1 and the activation of NLRP3 inflammasome were all increased, further supporting the hypothesis that the KCNQ1OT1 dysregulation may be the molecular mechanism of the pathogenesis of DR. Therefore, KCNQ1OT1 may serve as a new therapeutic target for DR.
Integrated Multi-Omic Data Analysis and Validation with Yeast Model Show Oxidative Phosphorylation Modulate Protein Aggregation in Amyotrophic Lateral Sclerosis
Authors: Swaroop Sai , PS Akhil , Pradhan Sai Sanwid , Prasad Bandana , Rao Raksha , Manjunath Meghana , Choudhary Bibha , Sivaramakrishnan Venketesh 
Published: September 2021

Abstract
Amyotrophic Lateral Sclerosis is a progressive, incurable amyloid aggregating neurodegenerative disease involving the motor neurons. Identification of potential biomarkers and therapeutic targets can assist in the better management of the disease. We used an integrative approach encompassing analysis of transcriptomic datasets of human and mice from GEO database. Our analysis of ALS patient datasets showed deregulation in Non-alcoholic fatty acid liver disease and oxidative phosphorylation. Transgenic mice datasets pertaining to SOD1, FUS and TDP-43 showed deregulation in oxidative phosphorylation and ribosome associated pathways. Commonality analysis between the human and mice datasets showed oxidative phosphorylation as a major deregulated pathway among the different datasets. Further, gene expression analysis of mitochondrial electron transport chain show downregulation of genes belonging to Complex I and IV. The results were then validated using the yeast model system. Inhibitor studies using metformin (complex-I inhibitor) and malonate (complex-II inhibitor) did not have any effect in mitigating the amyloids while antimycin (complex-III inhibitor) and azide (complex-IV inhibitor) reduced amyloidogenesis. Knock-out of QCR8 (complex-III) or COX8 (complex–IV) completely cleared the amyloids. Taken together, our results show a critical role for mitochondrial oxidative phosphorylation in amyloidogenesis and as a potential therapeutic target in ALS.
Anti-PT Transformations and Complex PT-Symmetric Superpartners
Authors: Kartal Sehban , Koohrokhi Taha , Mohammadi Ali 
Published: September 2021

Abstract
A quantum mechanical system with unbroken super-and parity-time (PT)-symmetry is derived and analyzed. Here, we propose a new formalism to construct the complex PT-symmetric superpartners by extending the additive shape invariant potentials to the complex domain. The probabilistic interpretation of a PT-symmetric quantum theory is correlated with the calculation of a new linear operator called the C operator, instead of complex conjugation in conventional quantum mechanics. At the present work, we introduce an anti-PT (A PT) conjugation to redefine a new version of the inner product without any additional considerations. This PT-supersymmetric quantum mechanics, satisfies essential requirements such as completeness, orthonormality as well as probabilistic interpretation.
Low Frequency-Repetitive Nerve Stimulation and Factors Affecting Decremental Response in Amyotrophic Lateral Sclerosis: A Retrospective Study of 449 Cases
Authors: Zhang Jinghong , Wang Hongfen , Yang Fei , He Zhengqing , Cui Fang , Li Mao , Sun Bo , Huang Xusheng 
Published: September 2021

Abstract
A number of studies have demonstrated that decremental response to low frequency repetitive nerve stimulation (LF-RNS) is frequently observed in amyotrophic lateral sclerosis (ALS). However, due to the small sample size involved in previous studies, large discrepancies exist about the positivity rates of LF-RNS tests and factors affecting decremental response. This retrospective study of 449 cases, the largest sample size ever reported, shows that the overall positivity rate of LF-RNS is 49.9%. 3Hz RNS delivered to the accessory nerve has the best sensitivity and highest positivity rate. It obviously increases in response to upper limb onset, disease progression rate < 0.5 score/month, definite ALS and electromyography positive(EMG(+)) in sternocleidomastoid muscle. There is a linear increase in the decrement percentage of CMAP amplitude at 3Hz RNS delivered to the accessory nerve in response to longer disease duration, longer MUP duration and greater MUP duration increment percentage. These findings substantially advance the understanding of RNS results in ALS patients and effectively instruct clinical application.
All-fiber ultrafast amplifier at 1.9 μm based on thulium-doped normal dispersion fiber and LMA fiber compressor
Authors: Voropaev Vasilii , Batov Daniil , Voronets Andrey , Vlasov Dmitrii , Jafari Rana , Donodin Aleksandr , Tarabrin Mikhail , Trebino Rick , Lazarev Vladimir 
Published: September 2021

Abstract
The duration reduction and the peak power increase of ultrashort pulses generated by all-fiber sources at a wavelength of 1.9 μm are an urgent tasks. Finding an effective and easy way to improve these characteristics of ultrafast lasers can allow a broad implementation of wideband coherent supercontinuum sources in the mid-IR range required for various applications. As an alternative approach of sub-100 fs pulse generation we present an ultrafast all-fiber amplifier based on a normal-dispersion germanosilicate thulium-doped active fiber and a large-mode-area silica-fiber compressor. The output pulses have the following characteristics: the pulse duration of 71 fs, the central wavelength of 1.9 μm, the repetition rate of 23.8 MHz, the energy per pulse period of 25 nJ, the average power of 600 mW, the maximum estimated peak power of 220 kW, and a random output polarization. The pulse intensity and phase profiles were measured via the second-harmonic-generation frequency-resolved optical gating technique. The dynamics of ultrashort pulses propagation in the amplifier was analyzed using numerical simulation.
Mathematical modeling and optimal intervention strategies of the COVID-19 outbreak
Authors: Mondal Jayanta , Khajanchi Subhas 
Published: September 2021

Abstract
32,737,939 active cases and 438,210 deaths because of COVID-19 pandemic were recorded on 30 August 2021 in India. To end this ongoing global COVID-19 pandemic, there is an urgent need to implement multiple population-wide policies like social distancing, testing more people and contact tracing. To predict the course of the pandemic and come up with a strategy to control it effectively, a compartmental model has been established. The following six stages of infection are taken into consideration: susceptible ($S$), asymptomatic infected ($A$), clinically ill or symptomatic infected ($I$), quarantine ($Q$), isolation ($J$) and recovered ($R$), collectively termed as SAIQJR. The qualitative behavior of the model and the stability of biologically realistic equilibrium points are investigated in terms of the basic reproduction number. We performed sensitivity analysis with respect to the basic reproduction number and obtained that the disease transmission rate has an impact in mitigating the spread of diseases. Moreover, considering the non-pharmaceutical and pharmaceutical intervention strategies as control functions, an optimal control problem is implemented to mitigate the disease fatality. To reduce the infected individuals and to minimize the cost of the controls, an objective functional has been constructed and solved with the aid of Pontryagin's Maximum Principle. The implementation of optimal control strategy at the start of a pandemic tends to decrease the intensity of epidemic peaks, spreading the maximal impact of an epidemic over an extended time period. Extensive numerical simulations show that the implementation of intervention strategy has an impact in controlling the transmission dynamics of COVID-19 epidemic. Further, our numerical solutions exhibit that the combination of three controls are more influential when compared with the combination of two controls as well as single control. Therefore the implementation of all the three control strategies may help to mitigate novel coronavirus disease transmission at this present epidemic scenario.
Complementary and Alternative Medicine application in cancer patients in Iran
Authors: Nejat Nazi , Rahbarian Amir , Mehrabi Fatemeh , Rafiei Fatemeh 
Published: September 2021

Abstract
Purpose

Nowadays, complementary and alternative medicine (CAM) is used by cancer patients all over the world. The aim of this study was to investigate the prevalence of CAM use in patients with cancer in Iran.
Methods

This descriptive-analytical study was conducted on 320 cancer patients in Arak. For gathering information, a researcher-made questionnaire was used. This questionnaire was consisted of two parts: demographic and clinical information; and patient’s attitude toward using complementary and alternative medicine treatments and their effectiveness, as well as how much they used different kinds of these treatments. The data was analyzed using SPSS software version 16.
Results

Our findings showed that average age of participants was 55.11 ± 15.58. Most of them had leukemia (25.9%) and underwent chemotherapy (55%), and 141 (44.3%) of individuals were using CAM. Majority of patients (73.2%) were using CAM to improve physical conditions, 61.4% were using it simultaneously with conventional medical treatments, and 25% to reduce pain. Participants have reported visiting holy places, yoga, prayer therapy, and using medicinal plants and special diets, respectively.
Conclusion

considering the high number of patients using CAM treatments, proper planning and implementation to educate professional members of health team, especially doctors and nurses about CAM treatments is essential. The most important CAM treatments to be educated are spiritual therapies, yoga, medicinal plants and diet therapy. Moreover, support and education about using these kinds of treatment, should be considered in the supportive care program for patients with cancer.
Process Limits in High Performance Peel Grinding of Hardened Steel Components With Coarse CBN Grinding Wheels
Authors: Denkena Berend , Kroedel Alexander , Wilckens Michael 
Published: September 2021

Abstract
Recent developments in the production processes for cubic boron nitride (CBN) abrasive grains have led to commercially available grain sizes larger than lg > 300 µm. These superabrasive grains allow higher material removal rates during grinding of hardened steel components. Currently, these components are pre-machined by turning processes before being hardened and eventually finished by grinding. However, the turning process can be substituted by grinding with coarse CBN-grains since higher depths of cut are achievable when machining hardened components. This paper investigates the process behaviour of vitrified and electroplated grinding wheels with large grain sizes during the machining of hardened steel components. Process forces, wear behaviour and workpiece surface roughness are investigated for three different grain sizes and the process limits of both bond types are examined.The investigations show that the vitrified tools do not fully suit the demands for peel grinding process with very high material removal rates since wear by means of bond breakage occurs. The electroplated tools on the other hand are capable of very high material removal rates. Their wear behaviour is characterized by clogging of the chip space if the process limit is reached. Even so, both tools outperform a standard hard-turning process in terms of process time by 74 % and 94 % respectively.
Impact of Type 1 Diabetes and Its Duration on Wall-to-lumen Ratio and Blood Flow in Retinal Arterioles
Authors: Stefański Adrian , Harazny Joanna M , Wolf Jacek , Miszkowska-Nagórna Eliza , Wolnik Bogumił , Narkiewicz Krzysztof , Schmeider Roland E 
Published: September 2021

Abstract
Background Subclinical damage to both the small and large vessels may contribute to the development and progression of cardiovascular disease. Scanning laser Doppler flowmetry (SLDF), an established method used to measure retinal microcirculation, has been successfully applied in hypertensive and post-stroke patients. To the best of our knowledge, no previous studies have assessed the impact of type 1 diabetes and its duration on retinal arteriole structure denoted by wall-to-lumen ratio (WLR) and retinal capillary flow (RCF). MethodsRetinal microcirculation was assessed in 158 patients with type 1 diabetes and 38 age-matched healthy controls. The diabetics were divided into 3 groups: group A with diabetes duration <12 months, group B with diabetes duration between 1 and 10 years, and group C >10 years of diabetes. Retinal capillary structure and perfusion were evaluated using a Heidelberg retina flowmeter and automatically analyzed with full-field perfusion imaging. Diabetes control was assessed by HbA1c measurement. ResultsBoth age and BMI were comparable in all the diabetic patients and the controls (mean age 24.8 ± 4.7 years, mean BMI 22.9 ± 4.1). The patients with newly diagnosed diabetes had the highest HbA1c (11.1%) whereas groups B and C were comparable in this respect (7.8% ± 1.9%; 8.0% ± 1.7%, respectively). In the univariate analyses, RCF was significantly higher in group A (297 ± 121 arbitrary units [AU]) vs group B (236 ± 52 AU; p = 0.007) and group C (236 ± 70 AU; p = 0.008) and comparable to that of the controls (p = 0.46). Additionally, the WLR was highest in group C compared to the other diabetic subgroups and controls (p = 0.47). ConclusionsNew-onset diabetes is associated with an increase in RCF, which then gradually decreased with the duration of the disease. Structural changes of the retinal arterioles estimated via WLR are evident later in the course of diabetes, especially when the disease duration exceeded 10 years. These results could not be explained by age or diabetes control. Our findings may have important implications for the understanding of the mechanisms underlying increased cardiovascular risk in type 1 diabetes.