bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Serum Vitamin D Levels in Children With Pityriasis Alba: A Retrospective Study
Authors: Chen Xiao-Yi , Xiao Jing , Ji Xiu-Wai , Gao Hai-Mei , Zhong Lian-Sheng 
Published: October 2021

Objective:
This study was performed to analyze the correlation between pityriasis alba (PA) and the serum 25-hydroxyvitamin D status in children.

Methods:
The study population comprised 460 patients with PA and 254 age- and sex-matched healthy controls. The serum level of 25-hydroxyvitamin D was compared between the two groups by student t test.

Results:
The serum level of 25-hydroxyvitamin D was significantly lower in patients with PA than in healthy controls (P < 0.001). There were statistically significant differences in the serum vitamin D status between the PA group and control group (P < 0.001); specifically, patients with PA had a significantly higher frequency of vitamin D deficiency (52.83% vs. 24.35%, P = 0.001) and lower frequency of vitamin D sufficiency (22.83% vs. 37.01%, P < 0.001) than controls. PA patients showed significantly lower serum level of vitamin D than controls in deficient and sufficient groups (P = 0.005 and 0.027, respectively), and in insufficient group, serum vitamin D level was lower in PA patients than in controls, but it showed no statistical difference (P = 0.061).

Conclusion:
Vitamin D may play a role in the pathogenesis of PA. Further investigations are required to establish the relationship between the severity of PA and the vitamin D status and to evaluate the potential for use of vitamin D in the treatment of PA.
Prevalence of Acne Inversa (Hidradenitis Suppurativa) in China: A Nationwide Cross-Sectional Epidemiological Study
Authors: Wang Zhong-Shuai , Li Jing , Ju Qiang , Lai Wei , Geng Song-Mei , Kang Xiao-Jing , Jiang Xian , Jin Hong-Zhong , Xie Hong-Fu , Sun Qing , Li Hang , Li Shan-Shan , Yuan Chen , He Li , Fang Hong , Wang Gang , Tao Juan , Gao Xing-Hua , Wu Yan , Lin You-Kun , Li Yu-Zhen , Gu Jun , Yan Yan , Wang Baoxi 
Published: October 2021

Abstract

Objective:
This study was performed to estimate the prevalence of hidradenitis suppurativa (HS) in China and describe the demographic and clinical features of HS in the Chinese population.

Methods:
This multicenter clinic-based cross-sectional study was conducted in dermatology clinics within 19 hospitals located in 15 cities/provinces across China from September to October 2020. The prevalence of HS was calculated as the percentage of patients with HS among all visitors at participating clinics during the 1-month study period. HS was independently diagnosed by two certified dermatologists at each site. All visitors at participating clinics were screened, and all patients with HS were invited to participate in a questionnaire survey to elucidate the demographics and clinical features of HS in the Chinese population.

Results:
We identified 92 patients with HS among 274,742 visitors at participating clinics. The prevalence rate was 0.03349% or 33.49 per 100,000 population (95% confidence interval, 26.64-40.32), and the female:male ratio was 1.0:4.7.

Conclusion:
The overall prevalence of HS in China was lower than that in Western and other Asian countries with a predominance of male patients.
Transcanal Transvestibular Endoscopic Neurectomy: First Experience
Authors: Marchioni Daniele , Caiazza Nicole , Calabrese Cinzia , Soloperto Davide 
Published: October 2021

Objective:
Ménière's disease is an idiopathic inner ear disorder characterized by recurrent vertigo, fluctuating sensorineural hearing loss, and persistent tinnitus. In 10% to 30% of cases, conservative therapy fails, and Ménière's disease is defined as intractable. In these patients, ablative techniques with unilateral vestibular deafferentation are mandatory. Several approaches for vestibular neurectomy, which preserve hearing capability, are described. In patients presenting severe dizziness associated with high-grade sensorineural hearing loss, surgical labyrinthectomy, or selected vestibular neurectomy through a translabyrinthine approach are the treatments commonly considered. This study reports the first application of transcanal transvestibular endoscopic neurectomy in two patients with frequent disabling vertigo and high-grade sensorineural hypoacusia.

Methods:
This was a retrospective chart review including patients with intractable Ménière's disease who underwent vestibular neurectomy, performed in our ENT department between January 2017 and January 2020, selecting patients with disabling vertigo and high-grade sensorineural hypoacusia. We describe step-by-step the surgical technique of transcanal transvestibular endoscopic neurectomy.

Results:
Overall, two patients underwent transcanal transvestibular endoscopic neurectomy. We performed transcanal transvestibular neurectomy in all cases. No intraoperative complications were observed. On the 2nd postoperative day, one patient presented CSF leak, leading to surgical revision. A complete resolution of vertigo attacks was observed 6 months after surgery.

Conclusion:
Even though this study presents a limited number of cases, transcanal transvestibular neurectomy is a promising, safe, and effective procedure in selected cases.
Effects of Danhong injection on cardiac function and blood lipid in patients with angina pectoris of coronary heart disease
Authors: Liang Jian , He Xiaojiao , Zhou Hongyu , Liang Peng 
Published: October 2021

Abstract

Background:
Angina pectoris of coronary heart disease is the leading cause of death worldwide. Danhong injection is a supplement for angina pectoris of coronary heart disease. A large number of studies have confirmed its efficacy and safety. However, there is no rigorous clinical study to evaluate the effects of Danhong injection on cardiac function and blood lipid in patients with angina pectoris of coronary heart disease.

Methods:
This is a prospective, randomized, double-blind, placebo-controlled trial to study the effects of Danhong injection on cardiac function and lipid profile in patients with angina pectoris of coronary heart disease. Participants will be randomly divided into treatment group and control group. The treatment group will be treated with Danhong injection and the control group will be treated with placebo under basic treatment according to recommended guideline, and followed up for 3 months after 14 consecutive days of treatment. Outcomes include: cardiac function (left ventricular end-diastolic diameter); left ventricular end-systolic diameter; left ventricular ejection fraction, blood lipid levels (total cholesterol; triacylglycerol; low density lipoprotein cholesterol; high density lipoprotein cholesterol), the number of angina attacks per week, total amount of nitroglycerin tablets, and adverse reactions.

Discussion:
This study will evaluate the efficacy of Danhong injection in improving cardiac function and blood lipid in patients with angina pectoris of coronary heart disease. The results of this study will provide reference for clinical use of Danhong injection to improve cardiac function and blood lipid in patients with angina pectoris of coronary heart disease.
Trial registration: OSF Registration number: DOI 10.17605/OSF.IO/TPZJ5.
The relationship between fetuin-A and coronary atherosclerotic heart disease (CHD) and CHD-related risk factors
Authors: Zheng Jianping , Huang Maozhi , Huang Qilei , Chen Qiaoxing , Chen Ziguo 
Published: October 2021

Abstract
Fetuin-A plays an important role in antivascular calcification and inflammatory response, it is necessary to explore the relationship between fetuin-A and coronary atherosclerotic heart disease (CHD) and CHD-related risk factors.
A total of 92 patients with CHD as the research group, and 60 healthy persons as the control group were enrolled from May 2019 to May 2020. Fetuin-A levels were determined by enzyme-linked immunosorbent assay, and the characteristics and clinical data were collected and compared. Logistic regression was used to analyze the factors influencing CHD.
The age, proportion of males, patients with hypertension and diabetes, as well as fetuin-A level in the research group were significantly higher than those in the control group, but the high-density lipoprotein cholesterol level was significantly lower than that in the control group (P < .05). Logistic regression analysis and correction showed that gender, age, blood pressure, and diabetes were related to the onset of CHD, and there was a significant correlation between the level of fetuin-A and age (P < .05).
Serum fetuin-A was related to the onset risk of CHD, and showed a significant correlation with age.
Effect of non-pharmacological interventions on sleep in preterm infants in the neonatal intensive care unit
Authors: Huang Qingchun , Lai Xin , Liao Jianhua , Tan Yingchao 
Published: October 2021

Abstract

Background:
Premature infants are prone to suffer multisystem complications after birth due to the incomplete development of organ tissues and low immunity, and they require a longer period of supervised treatment in the neonatal intensive care unit (NICU). However, due to the specificity of medical care in the NICU, the sleep of preterm infants is highly susceptible that has an impact on the prognosis of preterm infants. Recently, various non-pharmacological interventions have been applied to the sleep of preterm infants in the NICU, which have shown positive outcomes. However, the efficacy and safety of them are unclear. This study aims to evaluate the effects of non-pharmacological interventions on sleep in preterm infants in the NICU through a network meta-analysis.

Methods:
Randomized controlled trials of non-pharmacological interventions on sleep in preterm infants in the NICU published before September 2021 will be searched in online databases, including the Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, Wanfang, China Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web of Science. Two researchers will be independently responsible for screening and selecting eligible literatures, extracting data and evaluating the risk of bias in the included studies. Stata 14.0 software will be used for data analysis.

Results:
The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.

Conclusion:
This study will provide comprehensive and reliable evidence-based references for the efficacy and safety in different non-pharmacological interventions on sleep in preterm infants in the NICU.
Titanium elastic nailing can be used in 6 to 10 years old pediatric with Delbet IV femoral neck fractures
Authors: Zhu Dongsheng , Xu Xiangfei , Zhang Ming , Wang Tong 
Published: October 2021

Abstract
The purpose of this study was to analyze the outcomes of titanium elastic nail (TEN) for the children in 6 to 10 years old who sustained a Delbet IV femoral neck fracture.
A total of 56 children aged 6 to 10 years old with Delbet IV femoral neck fracture treated with TEN or cannulated screw (SC) were identified at our hospital from January 2009 to December 2019. Of which 24 were treated with TEN, and 32 with SC. All of them were followed up for 1 year after operation, and the differences in operation time, intraoperative blood loss, hospitalization time, hip joint function, and complication between the 2 groups were compared. Harris and Ratliff hip score were used to evaluate the hip function.
All 56 fractures united properly. No major complications were noted in both groups. The intraoperative blood loss and operation time in TEN group and SC group were (11.42 ± 3.41) mL, (19.66 ± 4.05) mL (P = .000) and (33.58 ± 7.89) min, (40.22 ± 7.48) min (P = .002), respectively. There was no significant statistical difference between hip regarding range of motion and femoral neck-shaft angle in both groups, as well as Harris and Ratliff hip score between the 2 groups.
TEN represent safe and effective methods in the treatment of Delbet IV femoral neck fracture in 6 to 10 years old children. TEN internal fixation is a minimal invasive and simpler technique and suitable for young children of Delbet IV femoral neck fracture.
Underwater endoscopic mucosal resection of a follicular lymphoma
Authors: Kim Tae Un , Kim Su Jin , Choi Cheol Woong 
Published: October 2021

Abstract

Introduction:
Endoscopic resection of a follicular lymphoma (FL) presenting as a gastric subepithelial tumor (SET), along with periodic follow up can be a treatment option because gastrointestinal FL cells tend to reside in the primary site, which may explain its indolent nature.

Patient concerns:
A gastric lesion was found incidentally during a screening endoscopy in 73-year-old woman without any gastrointestinal symptom.

Diagnosis:
The patient was diagnosed with a grade I FL that was 1.4 cm large, at the greater curvature of lower-body.

Intervention:
We performed underwater endoscopic mucosal resection (UW-EMR), and there was no serious complication, such as bleeding and perforation.

Outcomes:
Complete en bloc resection was achieved with UW-EMR. Follow-up endoscopic biopsy after 3 months revealed no residual tumor on the resection site.

Conclusion:
UW-EMR may be a simple and safe resection method for gastric FL without metastases, that measure >1 cm.
Lingual thyroid with severe hypothyroidism
Authors: Huang Hsuan , Lin Yi-Hsin 
Published: October 2021

Abstract

Introduction:
Ectopic thyroid tissue presenting at the base of the tongue, called lingual thyroid, is a clinical rarity. Clinical presentation varies depending upon either the severity of regional symptoms associated with the enlargement of gland size, or the features related to thyroid dysfunction.

Patient concerns:
We reported a case of a 29-year-old female who presented with symptoms of easy fatigue and depression for 3 months.

Diagnosis:
After a series of diagnostic workup, the lingual thyroid with severe hypothyroidism was diagnosed.

Intervention and outcome:
She received conservative treatment with thyroid hormone replacement and the symptoms improved significantly.

Lessons:
Lingual thyroid is a rare entity that needs careful diagnostic workup including clinical examination, biochemical tests, imaging methods such as ultrasonography, scintigraphy, computed tomography, magnetic resonance imaging, and fine-needle aspiration cytology to plan the management. Lingual thyroid with hypothyroidism and no neck regional symptoms can be conservatively treated and requires regular follow-up for the prevention of potential risk of malignant transformation.
Post-pregnancy osteoporosis-related multiple vertebral fractures associated with post-partum thyroiditis
Authors: Han Hyeong-Wook , Jeon Na-Mo , Lee Jae-Min , Kim Jae-Hyung 
Published: October 2021

Abstract

Introduction:
Osteoporosis is a condition commonly observed in elderly and postmenopausal women. Pregnancy and lactation-induced osteoporosis are rare, and the development of severe vertebral fractures is uncommon. Postpartum thyroiditis (PPT) is a minor cause of osteoporosis. To the best of our knowledge, the development of osteoporosis associated with pregnancy has not yet been reported.

Patient concerns:
Here, we report a rare case of post-pregnancy osteoporosis-related multiple vertebral fractures associated with PPT. A 25-year-old woman developed lower back pain after her first delivery. She was then admitted to our medical center because of aggravated back pain.

Diagnosis:
On radiographic examination, she had multiple compressions of the lumbar spine. Bone mineral density was associated with osteoporosis. Laboratory tests, thyroid scans, and thyroid ultrasonography were performed. The patient was diagnosed with PPT.

Interventions:
The patient stopped lactating immediately. She was administered bisphosphate at 3 mg/3 months intravenously, elementary calcium at 1000 mg/day, and calcitriol 0.5 μg/day.

Outcomes:
A month later, her pain was relieved by proper management and she could independently walk indoors.

Conclusion:
PPT might play a role in aggravating post-pregnancy osteoporosis. It should be considered as a differential diagnosis in patients presenting with postpartum osteoporosis-related multiple spine fractures.
Successful treatment of radiotherapy and apatinib in patient with mediastinal mixed non-seminomatous germ cell tumor
Authors: Ren Congcong , Zhao Jing , Kang Lin , Di Yan , Qiu Gang , Wang Qingxue 
Published: October 2021

Abstract

Rationale:
Mediastinal non-seminomatous germ cell tumors (MNSGCTs) are rare malignancies. Chemotherapy followed by surgical resection has been regarded as the standard management, but treatment options for chemotherapy-refractory patients or those with unresectable tumors are limited, resulting in a very poor prognosis.

Patient concerns:
An 18-year-old female presented with symptoms of cough, chest tightness, and shortness of breath for 2 months, and the symptoms gradually worsened.

Diagnosis:
Computed tomography (CT) revealed a large mediastinal mass invading the pericardium and great blood vessels. Serum human chorionic gonadotropin (HCG) and α-fetoprotein (AFP) levels were normal. Histopathological examination of biopsy specimens revealed mixed MNSGCT with embryonal carcinoma and immature teratoma components.

Interventions:
The patient achieved complete remission (CR) and long-term survival after multimodal therapy comprising chemotherapy, positron emission tomography/CT (PET/CT)-guided volumetric-modulated arc therapy (VMAT), and anti-angiogenic targeted therapy.

Outcomes:
The patient was followed up for more than 4 years without recurrence, metastasis, or treatment-related adverse effects.

Lessons:
The case presented here highlights the importance of multidisciplinary diagnosis and treatment, providing evidence that radiotherapy and anti-angiogenic therapy may play an important role in unresectable or residual tumors after failure of conventional treatments of MNSGCT. Percutaneous biopsy is necessary for diagnosis if the tumor is unresectable, and serum AFP and HCG levels are normal. Additionally, PET/CT is an effective method for evaluation of efficacy and radiotherapy guidance for patients with MNSGCTs.
Posttraumatic Vernet syndrome without fracture
Authors: Braut Tamara , Maršić Matej , Ravlić Iva , Maržić Diana , Marijić Blažen , Malvić Goran , Vrebac Ilinko , Velepič Marko 
Published: October 2021

Abstract

Rationale:
The aim of this case is to emphasize the need to include nerve traction in the differential diagnosis of nerve deficits associated with Vernet syndrome. This mechanism of injury has been described only once, but must not be overlooked and should be considered and included as a possible cause in diagnostic algorithms.

Patient concerns:
A patient presenting with dysphagia, extreme hoarseness, and limited shoulder movement after head injury was admitted to the emergency department.

Diagnoses:
Multidisciplinary evaluation was performed, and nerve traction-induced Vernet syndrome was established as a running diagnosis.

Interventions:
Intensive swallowing and speech exercises, assisted by a specialist, were performed.

Outcomes:
Swallowing and speech exercises significantly and objectively improved the patient's swallowing and voice, with mild hoarseness of voice remaining as the main symptom. Spectral acoustic analysis went from a voice pitch of 163.77 Hz to normal (187.77 Hz), jitter improved from 17.87% to 0.86% and shimmer values decreased from 39.86% to 19.60%. Breathiness during phonation measuring 2.91% was reduced to 1.08% and appropriate average intensity of voice (63.95 dB) was achieved. Initial dysphagia and fluid retention in the right piriform sinus, along with tracheal aspiration, were not observed in control fiberoptic endoscopic evaluation of swallowing.

Lessons:
According to our knowledge and literature data, this is the second reported case of posttraumatic Vernet syndrome without radiologically confirmed jugular foramen fracture, induced by nerve traction. Such patients need a prompt multidisciplinary approach in diagnosis and timely posttraumatic rehabilitation therapy for favorable clinical evolution and retrieval of nerve function.
Diarrhea in pediatric recipients of solid organ or bone marrow transplants
Authors: Phrommas Jirachart , Tanpowpong Pornthep , Getsuwan Songpon , Lertudomphonwanit Chatmanee , Chantarogh Songkiat , Anurathapan Usanarat , Treepongkaruna Suporn 
Published: October 2021

Abstract
Diarrhea is common in adults after solid organ transplantation (SOT) and bone marrow transplantation (BMT), but data in children are limited. Therefore, we aimed to determine the incidence and etiology of pediatric early-onset diarrhea in post SOT and BMT.
We reviewed children aged 6 months to 18 years who underwent liver transplantation, kidney transplantation or BMT between January 2015 and December 2019 with duration of diarrhea > 72 hours within the first 6 months after transplantation. Clinical data and diarrheal course were collected. Regression analyses were performed to define factors associated with the interested outcomes.
Among 252 transplanted patients, 168 patients (66.6%) had 289 documented episodes of diarrhea. A diagnosis of 68.2% of post-transplant diarrhea remained ‘indefinite’. Enteric infection in SOT and gastrointestinal acute graft-versus-host disease (GI-aGVHD) in BMT were the commonly identified etiologies. Among 182 episodes among BMT children, skin rash was more pronounced when compared the ones with diarrhea > 7 days vs ≤ 7 days (odds ratio [OR] 13.9; 95% CI 1.8, 107.6). Males were more likely to develop GI-aGVHD as compared to females (OR 8.9). We found that GI-aGVHD was more common in the ones with skin rash and the presence of white blood cells in stool examination (OR 8.4 and 3.1, respectively). Deaths occurred in 7.7%.
Two-thirds of post-transplant children experienced at least one episode of early-onset diarrhea, of which the etiology mainly remains undefined. Various clinical factors of prolonged/chronic diarrhea and GI-aGVHD may help clinicians when managing these children.
Effect of the COVID-19 pandemic in stroke code activations in the region of Madrid
Authors: Riera-López Nicolás , Fuentes Blanca , de Donlebún Jorge Rodríguez-Pardo 
Published: October 2021

Abstract
Acute sstroke is the most common time-dependent disease attended in the emergency medical service (EMS) of Madrid (SUMMA 112). Community of Madrid has been one of the most affected regions in Spain by the coronavirus disease 2019 (COVID-19) pandemic. A significant reduction in acute sstroke hospital admissions has been reported during the COVID-19 pandemic compared to the same period 1 year before. As international clinical practice guidelines support those patients with suspected acute stroke should be accessed via EMS, it is important to know whether the pandemic has jeopardized urgent pre-hospital stroke care, the first medical contact for most patients. We aimed to examine the impact of the COVID-19 in stroke codes (SC) in our EMS among 3 periods of time: the COVID-19 period, the same period the year before, and the 2019-2020 seasonal influenza period.
We compared the SC frequency among the periods with high cumulative infection rate (above the median of the series) of the first wave of COVID-19, seasonal influenza, and also with the same period of the year before.One thousand one hundred thirty SC were attended during the 3 periods. No significant reduction in SC was found during the COVID-19 pandemic. The reduction of hospital admissions might be attributable to patients attending the hospital by their means. The maximum SC workload seen during seasonal influenza has not been reached during the pandemic. We detected a nonsignificant deviation from the SC protocol, with a slight increase in hospitals’ transfers to hospitals without stroke units.