bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIAGNOSIS DAN TATALAKSANA SINDROM MARFAN
Authors: Husniah Imraatul 
Published: July 2021

ABSTRAK
Sindrom Marfan merupakan kelainan genetik jaringan ikat, bersifat autosomal dominan, dan disebabkan oleh mutasi pada gen fibrilin-1 gene (FNB1). Prevalensi sindrom Marfan yaitu 2-3 per 10.000 penduduk. Rasio perbandingan penderita antara laki-laki dan perempuan adalah sama. Sekitar 75% pasien mempunyai riwayat keluarga menderita penyakit ini. Gejala yang timbul sangat kompleks, meliputi gejala pada sistem kardiovaskular, okular, skeletal, pulmonal, dan kulit. Dilatasi root aorta merupakan penyebab utama yang meyebabkan morbiditas dan mortalitas pada penyakit sindrom Marfan. Diagnosis sindrom Marfan ditetapkan berdasarkan kriteria diagnostik Ghent nasology, untuk pasien dengan atau tanpa riwayat keluarga. Umumnya kriteria ini dilihat dari aneurisma/diseksi aorta dan ektopia lentis. Selain itu juga terdapat kriteria sistemik sebagai alat diagnostik untuk manifestasi klinis pada sistem organ lain. Diperlukan adanya monitoring pada pasien sindrom marfan untuk mengontrol keabnormalitasan pada aorta. Monitoring penyakit biasanya dilakukan dengan ekokardiografi, computed tomography (CT) dan cardiovascular magnetic resonance (CMR). Terapi pada sindrom Marfan terbagi atas terapi medis dan pembedahan. Terapi medis yang digunakan yaitu penghambat β, Angiotensin converting enzyme inhibitors (ACEi), selective angiotensin II type I receprtor blockers (ARB), dan doksisiklin. Terapi pembedahan meliputi operasi root aota, terapi operasi stabilisasi untuk skolisosis, dan ekstraksi diafragma iris dan lensa untuk managemen terapi okular. Kata kunci: Sindrom Marfan, FNB1, Root aorta, Ektopia lentis ABSTRACT Marfan syndrome is a connective tissue disorder, autosomal dominant and caused by mutation of fibrilin-1 gene (FNB1). Prevalence is 2-3 per 10.000. No gender differences. Approximately 75% of patients have a family background of this disease. The clinical manifestation is complex, included abnormalities in cardiovascular, ocular, sceletal, pulmonal and skin. Dilatation in the aortic root is the main cause of morbidity and mortality in this disease. Diagnosis of Marfan syndrome set based on Ghent nasology diagnostic criteria, for the patient with or without family history. More weight will be given to the two cardinal features of Marfan syndrome: aortic root aneurysm/dissection and ectopia lentis. There is also systemic criteria for diagnosed the other clinical manifestation. The monitoring of patients with Marfan syndrome should undergo an echocardiographic, computed tomography (CT) and cardiovascular magnetic resonance (CMR). The theraphy of Marfan syndrome is using both medical and surgery. The medical therapy is using a β blockers, Angiotensin converting enzyme inhibitors (ACEi), selective angiotensin II type I receprtor blockers (ARB), and doxycycline. Meanwhile the surgery included root aortic surgery, scoliosis stabilization surgery, and diaphragma extraction of iris and lense for the ocular therapy. Keywords: Marfan syndrome, FNB1, Aortic root, Ectopia lentis
Pembelajaran Qur’an Berdasarkan Klan
Authors: Yusuf Muhamad , Mayalibit M. Yasin Un. 
Published: July 2021

This study aims to find out about the traditional model of learning Qur’an based on clan which is applied with ritual religion that maintained by the community in Samate Village South Salawati District Raja Ampat Island. Using a qualitative research with a social phenomenology paradigm. The results of this study found that every fam or clan has the people who capable to teach the Qur’an to their family and also the availability of teachers in reading Qur’an in Samate Village are much enough if it seen from the number of fam or clan. The difference of learning technique between the teachers are caused by the factor of teacher education in developing religious education innovation more programmed. The policy in selecting the teachers leads to the kinship structure between teachers and students which is a tradition from generation to generation. The people there really maintain harmony even they have different teachers where it can create social stability among the community. The origin of learning Qur’an is where everyone in one family or clan in society who has the ability to read the Qur’an has the opportunity to developing Qur’an education even that person does not receive a formal education.
Macrophage Migration Inhibitory Factor in Vitiligo: Pathogenesis and Potential Therapeutic Aspects
Authors: Ibrahim Hassan Mohammed , Abd El-Aziz Nada Essam El-din , Abdel-Hamid Ali Soheir , Hegazy Eisa Mohamed , Hassan Mohammed H. 
Published: July 2021

Vitiligo is an acquired skin disorder that is characterized by a gradual loss of skin pigmentation when melanocytes, the skin's pigment-producing cellsis lost. Pathogenicmechanisms are not well understood. Genetic, abnormal biochemical pathways, autoimmune, melanocyte adhesion deficits and nervous system imbalances are among the pathogenic triggers. Vitiligo lesions have also been shown to have macrophage infiltration.Macrophagemigration inhibitory factor (MIF) is a lymphokine that concentrates macrophages at inflammatory sites and is involved in cell-mediated immunity.MIF enhances chemotaxis and macrophage infiltration and upregulates inflammatory responses by inducing the expression of proinflammatory mediators such as TNF-α, nitric oxide and prostaglandin E2.Therapyfor vitiligo includes corticosteroids, immunomodulatory agents, vitamin D nalogues, antioxidants, phototherapy, laser and surgical therapy.However, no single treatment for vitiligo produces consistently good results and treatment response is variable. Narrow-band ultraviolet (NB-UVB, 311–313nm) phototherapy is viewed as backbone of treatment. Systemic therapies such as systemic corticosteroids and methotrexate were previously used to treat vitiligo which was assumed to be auto-immune nature.Pathogenic mechanisms, role of MIF and various treatment guidelines are discussed in this review
Physico-Chemical Quality Assessment of Various Bottled Commercial Water Brands in Okada Town, Edo State, Nigeria
Authors: Ngubi F. W. , Eiroboyi I. 
Published: July 2021

In this study, Physico-chemical assessment of some commercial drinking water sold in bottles in Okada Town was evaluated to ascertain their compliance with World Health Organization (WHO) and Nigerian Industrial Standard (NIS): Nigerian Standard for Drinking Water Quality threshold limits using standard analytical methods. Seven different bottled water samples obtained from different manufacturers labelled BWA to BWG were analyzed physically and chemically. Physical examination of the samples showed that they were odourless, colourless, and tasteless. Chemical quality parameters examined were pH, Chloride (Cl-), total hardness (TS), Phosphate (PHO3-), Nitrate (NO3-), Sulphate (SO42-), Iron (Fe), Potassium (K), Sodium (Na), Manganese (Mn), Zinc (Zn), total dissolved solids (TDS), conductivity, turbidity, and total suspended solids (TSS). The pH values of 57.1% of the water samples (BWA, BWB, BWC, BWE & BWF) were within the standards. The remaining chemical quality parameters (Cl-, TS, PHO3-, NO3-, Sulphate SO42-, Iron Fe, K, NA, Mn, Zn, TDS, Conductivity, turbidity, and TSS) of the branded bottled water samples were within the standards for clean and safe drinking. Therefore, they were considered safe and fit for human consumption.
Comparative Study of Native or Nano Quercetin on Epigenetic Modification and Nephropathy Biomarkers Post Challenges in Diabetic Hamsters
Authors: Nassar Soha Shebel , Sadek Mona Ahmed , Ismail Huda Mohamed , Moram Gehan Salah El-Din 
Published: July 2021

Aims: The aim of this study is to examine the regulatory effects of quercetin nanoparticles (QNPs) compared with native quercetin either with or without metformin against the abnormal molecular and biochemical pathways that eventually culminate in the pathologic condition clinically known as diabetic nephropathy (DN) in hamsters
Methodology: After synthesis and characterization of the QNPs, seventy male adult hamsters are divided as following; G1:healthy control, G2:untreated DN hamsters, G3:DN+metformin G4:DN+native quercetin, G5:DN+QNPs, G6:DN+native quercetin+ metformin and G7: DN + QNPs + metformin.
Results: Our results illustrated that the effect of QNPs + metformin is the most effective in IRS-1 and GLUT-4 gene expression that correlated with inhibition of HDACs which in turn improved diabetic and nephropathy biomarkers, this effectiveness followed by G6 then G3 and finally G4 after G5. These results were confirmed by immunohistochemical examinations. Levels of antioxidant and inflammatory biomarkers also reflected the protective effect of our treatments.
Conclusion: All tested treatments significantly exhibit renal improvement.
Incidence and Management of Post Cholecystectomy Biliary Fistula at Tertiary Care Hospital
Authors: Haq Ahtesham-Ul- , Memon Sohail Ahmed , Memon Riaz Ahmad , Rasool Bilal , Khatti Shahnawz , Khatoon Shahida 
Published: July 2021

Objective: To determine the incidence and management of post cholecystectomy biliary fistula at tertiary care Hospital.
Methodology: This was a prospective study which was conducted at general surgery department of Liaquat University of Medical and health Sciences, during one year from March 2017 to February 2018. All the patients those underwent laparoscopic cholecystectomy or open cholecystectomy, age more than15 years and either of gender were included. All the patients were evaluated for developed biliary fistula after cholecystectomies. All the patients of biliary fistula were managed conservatively and surgically and their management outcome was recorded. After operation most of patients were followed up to 6 months. The data was collected via study designed proforma. Data was analyzed by using SPSS version 20.
Results: Out of 318 patients, 280 patients underwent laparoscopic cholecystectomies, 38 patients underwent open cholecystectomies. Mean age of the patients was 41.34+8.23 years. Females were in majority 233(73.3%) and males were 95(29.7%). Out of all post-cholecystectomy biliary fistula was seen in 10(3.14%) patients. Incidence of post-cholecystectomy biliary fistula was insignificantly associated with types of cholecystectomies (p=0.425), while it was highly prevalent in females (p=0.001).
Conclusion: In the conclusion of this study the post cholecystectomy biliary fistula was observed to be 3.14% and mostly patients were manged via conservative treatment.
Evaluation of the Skin Infections and Conditions among Students of Gomal Medical College Pakistan
Authors: Parveen Shumaila , Alahmadi Yaser M. , Adnan Faryal , Darr Eshawa , Alalawi Ali , Rizvi Syed Shafqat Ali Shah , Awan Sadaqat Hussain , Ahmed Awais , Shahzad Muhammad Asif , Ahmed Tahseen , Shaikh Abdul Rashid , Mangi Altaf Ali 
Published: July 2021

Objective: The objective of the current study is to determine the pattern of dermatological disorders and to find out their connection with different socioeconomically factors among students of the Medical College.
Methodology: The Cross sectional observational study was carried out for the period of three months .The research instrument used was the well developed questionnaire.
Results: The questionnaire was administered among total 350 students and the most participant age group was the > 22 and that was about 47.4% of the total sample size the more skin complication seen was the acne that was about 59.7%, in addition to this dandruff contributed very heavily to the hair complexities which makes about 35.7% of the sample.
Conclusion: Skin infections especially the cosmetic are very common among the Medical students.
A Compact Analytical Profile of Aripiprazole: Analytical Methodologies
Authors: Athira O. V. , Rishad Muhamed , Babu K. Anand , Praseetha K. , Indukala . , Kathirvel S. 
Published: July 2021

Aripiprazole (APZ) is an antipsychotic drug that belongs to benzisoxazole derivatives and is used to treat schizophrenia as well as acute manic or mixed effects in patients with bipolar 1 disorder. APZ is used to treat certain mental, mood disorders such as bipolar disorder, Schizophrenia, Tourette's syndrome, and irritability associated with autistic disorder. It may also be used in combination with other medication to treat depression. The present review article would be useful for prospective studies for researchers interested in APZ formulation production and quality management. Using a thorough computer assisted literature survey; this review touches upon the various reported analytical methods for the quantification of APZ both in API (Active Pharmaceutical Ingredient) and pharmaceutical dosage forms. The present write-up also encompasses the various published research articles like Spectroscopy techniques, X- Ray Diffraction (XRD), Electro Chemical Technique, Differential Scanning Calorimeter (DSC) and Capillary Electrophoresis. This is the first review article in this series with focus on the analytical profile of APZ. Although, several methods were reported in the literature, HPLC stands out first for the quantification of APZ.
Steps towards Universal Health Coverage through Health and Wellness Center under Ayushman Bharat Programme Delivering Comprehensive Primary Health Care in Bhandara District
Authors: Ambekar Shrikant Madhukar , Quazi S. Z. , Gaidhane Abhay , Patil Manoj 
Published: July 2021

Background: In 2018-19 as recommended by National Health Policy an Ambitious health care scheme as Ayushman Bharat programme was started by Government of India steps toward the Universal health coverage. Ayushman Bharat is also known as Healthy India having two major component. Creation of Health and Wellness Centres and Pradhan Mantri Jan Arogya Yojana (PM-JAY). Comprehensive primary health care services will be delivered up gradation of existing health facility in various 10 core area and 13 different types of health services will be delivered at HWC health facility.
Progress in Health and Wellness under Ayushman Bharat Programme: First HWC was inaugurated by GOI in state of Chhattisgarh within Bijapur district at jangla village of Bhairamgarh Taluka on On 18th April 2018. Till 06th Feb 2021 total 58961 Health and wellness cneters are operational in India and In Maharashtra total 8423 Health and wellness cneters are operational where in Bhandara district total 177 Health and wellness cneters are operational which include 143 SHC Health and wellness center, 33 PHC Health and wellness center and 1 UPHC Health and wellness center.
Achievements in Health and Wellness Center: In Bhandara district 98% of Medical Officer, 90% of Staff Nurse, 93% of MPW Female, 88% of MPW Male and 99% of ASHA trained NPCDCS Programme. Where 10,69,219 screening test for Hypertension and 10,81,901 screening test for Diabetes conducted in HWC health facility. Total 4097 Yoga sessions conducted at HWC health facility.
Conclusion: 13 different types of health services which are delivered at Health and Wellness Centres health facility under Ayushman Bharat is step towards the Unvarsal health coverage provision in rural area of bhandara district.
Case Report on Left Ovarian Torsion: A Rare Complication in an Adolescent PCOS
Authors: Priyanjali . , Mohammed Shazia , Acharya Neema , Salve Mehul , Singh Priyanka 
Published: July 2021

Introduction: Ovarian torsion is an acute emergency and women in any age group having cysts may have this complication. With increase in number of women having PCOS mainly adolescent girls are also at risk of this complication. Here we report a case of young PCOS girl who presented with acute abdomen who was found to have left ovarian torsion. The emergency was managed by emergency laparoscopic derotation and oophoropexy.
Main symptoms and clinical findings: A 14 year old girl with PCOS presented with severe pain over right lower abdomen and was associated with 2 episodes of non-bilious vomiting. On examination she was anxious with tachycardia of 104 bpm. Right iliac fossa was tender without any distension, guarding or rigidity.
Main diagnoses, therapeutic interventions, and outcomes: Her lab investigation revealed leukocytosis with hormonal profile consistent with PCOS. On USG there was bulky left ovary of 7.9 x 5.5 x 4 cms and volume of 87cc with lack of arterial blood flow. She was promptly taken up for emergency laparoscopy where left ovary was rotated 360 degree clockwise with gangrenous looking cyst wall which improved on detorsion. Left ovary was then fixed to lateral pelvic wall in anatomical position.
Conclusion: All adolescent girls with ovarian torsion but no apparent ovarian pathology should be tested for PCOS using ultrasound and biochemical tests. Also girls with known PCOS in this age group presenting with acute abdomen, ovarian torsion should be considered and promptly investigated.
The Use of Bacteriophages and Immunological Monitoring for the Treatment of a Case of Chronic Septicemic Cutaneous Ulcerative Disease in a Loggerhead Sea Turtle Caretta caretta
Authors: Greene Whitney , Chan Benjamin , Bromage Erin , Grose Julianne H. , Walsh Cathy , Kortright Kaitlyn , Forrest Sue , Perry Grace , Byrd Lynne , Stamper M. Andrew 
Published: July 2021

Abstract
In this case study, phage therapy was applied to treat a multidrug-resistant case of septicemic cutaneous ulcerative disease (SCUD) caused by Citrobacter freundii in a loggerhead sea turtle Caretta caretta. Phages were applied topically, intravenously, into the carapace, and into the exhibit water using various phage cocktails specific to the causative agent over an 8-month period. This was performed in conjunction with antimicrobial therapy. The animal was monitored through weekly cultures, photographs, and complete blood cell counts, as well as immune assays (phagocytosis, plasma lysozyme and superoxide dismutase activity, and plasma electrophoresis profiles). The animal, in comparison to an untreated, unaffected control, had elevated antibody titers to the administered phages, which persisted for at least 35 weeks. Although cultures were clear of C. freundii after phage treatment, the infection did return over time and immune assays confirmed deficiencies when compared to a healthy loggerhead sea turtle. Immune parameters with statistically significant changes over the study period included the following: decreased phagocytosis, increased alpha- and gamma-globulin protein components, and an increased albumin : globulin ratio. When C. freundii appeared again, the multidrug-resistant status had reverted back to normal susceptibility patterns. Although not completely known whether it was another subspecies of bacteria, the therapy did resolve the multidrug-resistant challenge. Phage therapy in combination with antimicrobial agents may be an effective treatment for sea turtles with normally functioning immune systems or less-severe infections. Additional research is needed to better understand and quantify sea turtle immunology.
Flexible Osteogenic Glue as an All‐In‐One Solution to Assist Fracture Fixation and Healing
Authors: Tang Jincheng , Xi Kun , Chen Hao , Wang Lingjun , Li Dongya , Xu Yun , Xin Tianwen , Wu Liang , Zhou Yidi , Bian Jiang , Cai Zhengwei , Yang Huilin , Deng Lianfu , Gu Yong , Cui Wenguo , Chen Liang 
Published: July 2021

AbstractOsteogenic glue that reproduces the natural bone composition represents the final frontier of orthopedic adhesives with the potential to revolutionize surgical strategies against comminuted fractures. However, it is difficult to achieve an all‐in‐one formula, which could provide flexible and reliable adhesiveness while avoiding interfering with or even promoting the healing of glued fractures. Herein, an osteogenic glue characterized by inorganic‐in‐organic integration between amine‐modified mesoporous bioactive glass nanoparticles (AMBGN) and bioadhesive gelatin‐dextran network (GelDex) is introduced as an all‐in‐one tool to flexibly adhere and splice bone fragments and subsequently guide fracture healing during degradation. Relying on such integration, a 4‐fold improvement in cohesiveness is presented, followed by a nearly 5‐fold enhancement in adhesive strength in ex vivo porcine bone samples. The reversible and re‐adjustable adhesiveness also enables glue to effectively splice intricate fragments from highly comminuted fractures in the rabbit radius in an in vivo environment. Moreover, well‐preserved organic–inorganic integrity during degradation of the glue guides sustained interfacial osteogenesis and achieve satisfying healing outcomes in glued fractures, as observed by the 2‐fold improvement in biomechanical and radiological performance compared with commercially available cyanoacrylate adhesives. The current findings propose an all‐in‐one solution for the fixation of bone fragments during surgery.
2D Layered Dipeptide Crystals for Piezoelectric Applications
Authors: Zelenovskii Pavel S. , Romanyuk Konstantin , Liberato Michelle S. , Brandão Paula , Ferreira Fabio F. , Kopyl Svitlana , Mafra Luís M. , Alves Wendel A. , Kholkin Andrei L. 
Published: July 2021

Abstract2D piezoelectric materials such as transition metal dichalcogenides are attracting significant attention because they offer various benefits over bulk piezoelectrics. In this work, the fabrication of layered biomolecular crystals of diphenylalanine (FF) obtained via a co‐assembly of l,l‐ and d,d‐ enantiomers of FF monomers is reported. Their crystal structure, thermal and chemical stabilities, and piezoelectric properties are investigated. Single crystal X‐ray diffraction results show that FF enantiomers are arranged in the form of bilayers consisting of monomers with alternating chirality packed into a tape‐like monoclinic structure belonging to a polar space group P21. Each bilayer (≈1.5 nm thick) demonstrates strong out‐of‐plane piezoelectricity (d33 ≈ 20 pm V−1) that is almost an order of magnitude higher than in the archetypical piezoelectric material quartz. The grown crystals demonstrate better thermal and chemical stabilities than self‐assembled hexagonal FF nanotubes studied in the past. Piezoelectric bilayers, being held via weak aromatic interaction in the bulk crystals, can be exfoliated by mechanical or chemical methods, thus resulting in a 2D piezoelectric material, which can find various applications in biocompatible and ecologically friendly electromechanical microdevices, such as sensors, actuators, and energy harvesting elements used in implantable and wearable electronics.
Tuning the Electrolyte Solvation Structure to Suppress Cathode Dissolution, Water Reactivity, and Zn Dendrite Growth in Zinc‐Ion Batteries
Authors: Liu Sailin , Mao Jianfeng , Pang Wei Kong , Vongsvivut Jitraporn , Zeng Xiaohui , Thomsen Lars , Wang Yanyan , Liu Jianwen , Li Dan , Guo Zaiping 
Published: July 2021

AbstractThe cycle life of aqueous zinc‐ion batteries (ZIBs) is limited by the notable challenges of cathode dissolution, water reactivity, and zinc dendrites. Here, it is demonstrated that by tuning the electrolyte solvation structure, the issues for both the electrodes and the electrolyte can be addressed simultaneously. Specifically, a fire‐retardant triethyl phosphate (TEP) is demonstrated as a cosolvent with strong solvating ability in a nonaqueous/aqueous hybrid electrolyte. The TEP features a higher donor number (26 kcal mol−1) than H2O (18 kcal mol−1), preferring to form a TEP occupied inner solvation sheath around Zn2+ and strong hydrogen bonding with H2O. The TEP coordinated electrolyte structure can inhibit the reactivity of H2O with V2O5 and leads to a robust polymeric‐inorganic interphase (poly‐ZnP2O6 and ZnF2) on zinc anode effectively preventing the dendrite growth and parasitic water reaction. With such an optimized electrolyte, the Zn/Cu cells perform high average Coulombic efficiency of 99.5%, and the full cell with a low capacity ratio of Zn:V2O5 (2:1) and lean electrolyte (11.5 g Ah−1) delivers a reversible capacity of 250 mAh g−1 for over 1000 cycles at 5 A g−1. This study highlights the promise of a successful electrolyte regulation strategy for the development of high‐performance and practical ZIBs.