bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclosporine A blocks autophagic flux in tubular epithelial cells by impairing TFEB‐mediated lysosomal function
Authors: Li Zhi‐hang , An Ning , Huang Xi‐jie , Yang Chen , Wu Hong‐luan , Chen Xiao‐cui , Pan Qing‐jun , Liu Hua‐feng 
Published: May 2021

AbstractCyclosporine A (CsA) is an immunosuppressor widely used for the prevention of acute rejection during solid organ transplantation. However, severe nephrotoxicity has substantially limited its long‐term usage. Recently, an impaired autophagy pathway was suggested to be involved in the pathogenesis of chronic CsA nephrotoxicity. However, the underlying mechanisms of CsA‐induced autophagy blockade in tubular cells remain unclear. In the present study, we observed that CsA suppressed the activation and expression of transcription factor EB (TFEB) by increasing the activation of mTOR, in turn promoting lysosomal dysfunction and autophagy flux blockade in tubular epithelial cells (TECs) in vivo and in vitro. Restoration of TFEB activation by Torin1‐mediated mTOR inhibition significantly improved lysosomal function and rescued autophagy pathway activity, suppressing TEC injury. In summary, targeting TFEB‐mediated autophagy flux represents a potential therapeutic strategy for CsA‐induced nephrotoxicity.
Bilirubin is inversely related to diabetic peripheral neuropathy assessed by sural nerve conduction study
Authors: Abe Kentaro , Maeda Yasutaka , Matsuzaki Chitose , Yokomizo Hisashi , Inoue Tomoaki , Sonoda Noriyuki , Ogawa Yoshihiro , Inoguchi Toyoshi 
Published: May 2021

AbstractAims/IntroductionDiagnosis of diabetic peripheral neuropathy (DPN) depends on subjective findings, certain investigations for DPN risks have not been performed enough. Bilirubin protects against vascular complications by reducing oxidative stress in diabetes, but is not fully tested for DPN. This study aimed to evaluate sural nerve conduction impairments (SNCI) as an objective DPN marker and the contribution of bilirubin to SNCI.Materials and methodsUsing DPN‐Check®, SNCI was defined as a decline of amplitude potential or conduction velocity below the normal limit in 150 inpatients with diabetes. The correlations between SNCI and conventional DPN diagnosis criteria, the incidence of diabetic retinopathy/nephropathy, biomarkers for atherosclerosis, cardiac function by ultrasonic cardiogram, and bilirubin were statistically tested, followed by the comparison of logistic regression models for SNCI to find confounders with bilirubin.ResultsThe incidence of SNCI was 72.0%. The sensitivity and specificity of SNCI for DPN prediagnosis by simplified criteria were 54.6 and 90.5%, respectively, and similarly corresponded with diabetic retinopathy and nephropathy (sensitivity 57.4 and 50.0%, respectively). SNCI significantly related to diabetes duration, declined estimated glomerular filtration rate, albuminuria and total bilirubin. SNCI incidence was attenuated in the higher bilirubin tertiles (89.8/65.3/54.8%, P < 0.001). Bilirubin was an independent inverse risk factor for SNCI, even after adjustment by known risk factors for DPN and markers for microvascular complications.ConclusionsSNCI is a comprehensive marker for diabetic complications. We first showed the independent inverse relationship between bilirubin and SNCI through the independent pathway with other complications, provably reducing oxidative stress, as previously reported.
Impact of resin composite cement on color of computer‐aided design/computer‐aided manufacturing ceramics
Authors: Liebermann Anja , Mandl Alicia , Eichberger Marlis , Stawarczyk Bogna 
Published: May 2021

AbstractObjectiveTo analyze the impact of the color of a resin composite cement (RCC) on the optical properties of different computer‐aided design and computer‐aided manufacturing (CAD/CAM) ceramics.Materials and methodsSpecimens (N = 220, thickness: 0.9 ± 0.03 mm) were fabricated from: leucite (Initial LRF Block/IPS Empress CAD), lithium disilicate (Amber Mill/IPS e.max CAD), lithium metasilicate (Celtra Duo), and lithium alumina silicate ceramic (n!ce) in translucency levels HT and LT. All specimens were bonded with an RCC (Light+/Warm+). Color was analyzed (spectrophotometer) initially as well as after bonding of RCC with CAD/CAM ceramics using CIELab and CIEDE2000. Kolmogorov–Smirnov test, one‐way ANOVA and t test served for analyzing (α = 0.05).ResultsHighest impact on ΔE presented the choice of ceramic (ηp2 = 0.155/p < 0.001), followed by translucency level (HT/LT; ηp2 = 0.050/p = 0.001) as well as interaction between ceramic and translucency level (ηp2 = 0.175/p < 0.001). ΔE00 was mainly influenced by the choice of ceramic (ηp2 = 0.490/p < 0.001), the shade of resin composite (ηp2 = 0.031/p = 0.012) as well as the interaction between ceramic and resin composite (ηp2 = 0.258/p < 0.001).ConclusionsRCC shades presented differential impacts on color change of CAD/CAM ceramics.Clinical significanceKnowledge of the impact of available RCC shades on different CAD/CAM ceramics is crucial for an esthetic outcome and proper selection of ceramic restorations.
Diagnostic accuracy of virtual cognitive assessment and testing: Systematic review and meta‐analysis
Authors: Watt Jennifer A. , Lane Natasha E. , Veroniki Areti Angeliki , Vyas Manav V. , Williams Chantal , Ramkissoon Naveeta , Thompson Yuan , Tricco Andrea C. , Straus Sharon E. , Goodarzi Zahra 
Published: May 2021

AbstractBackground/ObjectivesVirtual (i.e., telephone or videoconference) care was broadly implemented because of the COVID‐19 pandemic. Our objectives were to compare the diagnostic accuracy of virtual to in‐person cognitive assessments and tests and barriers to virtual cognitive assessment implementation.DesignSystematic review and meta‐analysis.SettingMEDLINE, EMBASE, CDSR, CENTRAL, PsycINFO, and gray literature (inception to April 1, 2020).Participants and interventionsStudies describing the accuracy or reliability of virtual compared with in‐person cognitive assessments (i.e., reference standard) for diagnosing dementia or mild cognitive impairment (MCI), identifying virtual cognitive test cutoffs suggestive of dementia or MCI, or describing correlations between virtual and in‐person cognitive test scores in adults.MeasurementsReviewer pairs independently conducted study screening, data abstraction, and risk of bias appraisal.ResultsOur systematic review included 121 studies (15,832 patients). Two studies demonstrated that virtual cognitive assessments could diagnose dementia with good reliability compared with in‐person cognitive assessments: weighted kappa 0.51 (95% confidence interval [CI] 0.41–0.62) and 0.63 (95% CI 0.4–0.9), respectively. Videoconference‐based cognitive assessments were 100% sensitive and specific for diagnosing dementia compared with in‐person cognitive assessments in a third study. No studies compared telephone with in‐person cognitive assessment accuracy. The Telephone Interview for Cognitive Status (TICS; maximum score 41) and modified TICS (maximum score 50) were the only virtual cognitive tests compared with in‐person cognitive assessments in >2 studies with extractable data for meta‐analysis. The optimal TICS cutoff suggestive of dementia ranged from 22 to 33, but it was 28 or 30 when testing was conducted in English (10 studies; 1673 patients). Optimal modified TICS cutoffs suggestive of MCI ranged from 28 to 31 (3 studies; 525 patients). Sensory impairment was the most often voiced condition affecting assessment.ConclusionAlthough there is substantial evidence supporting virtual cognitive assessment and testing, we identified critical gaps in diagnostic certainty.
Methodology and optimization tool for a personalized low environmental impact and healthful diet specific to country and season
Authors: Walker Christie , Pfister Stephan , Hellweg Stefanie 
Published: May 2021

AbstractTo remain within the limits of the planetary boundaries and address increasing disease rates due to poor eating habits, there needs to be a major shift in dietary patterns. The composition of an optimal diet changes depending on location, season, and personalized dietary needs. We develop a methodology to build a 500+ food item, nutrient, and environmental impact database specific to a given country and month, which includes several life cycle stages of a food item and calculates impacts depending on from where the item is sourced. This database is then used to develop a detailed and personalized, healthful, low impact diet by using linear optimization. We applied this methodology to several case studies to compare what low impact diets would look like depending on country (Switzerland vs. Spain), season (August vs. February), sex, the inclusion of dietary supplements, and for different diet types and impact categories (climate change and biodiversity loss). Results indicate that, although optimized diets are similar, there are marked differences in the detailed composition depending on country, season, and impact considered, especially regarding legume choice. The lowest impact diet contained local and imported foods as well as fish. Vegan diets had the lowest impact only when incorporating a supplement to meet nutrient needs. We developed a tool to be used for personalized diet composition assessments for any global geographical location and season. We anticipate this work to be useful for developing country‐ and season‐specific dietary guidelines and for consumers hoping to reduce their own personal impacts.
A novel treatment of intertrigo in athletes and overweight subjects
Authors: Verzì Anna Elisa , Nasca Maria Rita , Dall’Oglio Federica , Cosentino Chiara , Micali Giuseppe 
Published: May 2021

AbstractBackgroundIntertrigo is a recurrent inflammatory dermatosis involving large/small body folds. Skin barrier products represent the mainstay of treatment in uncomplicated mild/moderate intertrigo.AimsTo assess by clinical and instrumental evaluation the efficacy and tolerability of a new barrier spray containing zinc gluconate‐taurine complex and zinc oxide combined with panthenol, glycerin, and Shea (Butyrospermum parkii) butter in mild‐to‐moderate intertrigo in athletes and overweight subjects.MethodsIn this open‐label prospective trial, 20 adult patients, with mild/moderate intertrigo enrolled at the Dermatology University Clinic of Catania (Italy), were instructed to apply the spray twice daily for 30 days. Degree of erythema was performed clinically and by polarized dermoscopy using a 5‐point severity scale (from 0=no erythema to 4=severe erythema) at baseline, and at 15 and 30 days. The measurement of pruritus was carried out by a subject‐completed visual analog scale (VAS) (from 0 mm=no pruritus to 100 mm=severe pruritus), at all time points. An Investigator Global Assessment (IGA) using a 6‐point scale (from −1=worsening to 4=complete response/clear) was also conducted at 30 days, along with a self‐administered tolerability questionnaire. Statistical analysis was performed using SAS version 9.ResultsAt 15 days, a statically significant reduction from baseline in erythema severity (mean from 3.4 ± 0.3 to 2.5 ± 0.2) along with pruritus intensity (mean from 70 ± 15.4 mm to 40 ± 9.5 mm) was observed. At 30 days, all evaluated parameters showed a further progressive statistically significant reduction from baseline. No relevant side effects were recorded.ConclusionsOur results suggest that the tested spay containing antiseptic/anti‐inflammatory and anti‐irritation agents may represent a valid therapeutic option for mild/moderate intertrigo.
Self‐stigma and psychosocial burden of patients with port‐wine stain: A systematic review and meta‐analysis
Authors: Wanitphakdeedecha Rungsima , Sudhipongpracha Tatchalerm , Ng Janice Natasha C. , Yan Chadakan , Jantarakolica Tatre 
Published: May 2021

AbstractBackgroundPort‐wine stain (PWS) is a congenital malformation that does not resolve spontaneously and can lead to social and self‐stigma. However, little is known about how PWS affects the patients' quality of life (QoL) and psychosocial well‐being. In this article, we examine the existing empirical evidence on self‐stigma caused by PWS.MethodsA systematic review was done using MEDLINE, PubMed, Embase, and Cochrane databases on January 15, 2021 to retrieve all case reports, cohort studies, and clinical trials written in English. The keywords used in this literature search included port‐wine stain, quality of life, self‐stigma, and social stigma.ResultsFrom the 74 initial records, eight articles were quantitative studies that assessed the QoL and self‐stigma experienced by PWS patients. With regard to perceived stigma or the patients’ understanding of how others think and act toward them, we found that the parents of children with facial PWS tend to have more perceived stigma than the children. For anticipated stigma or expectations of future stigma, young patients with PWS have less or no concern about their skin conditions. In terms of enacted stigma or experiences with discriminatory acts, there were significant differences in the QoL score between patients with facial PWS and those with non‐facial PWS.ConclusionThis study suggests that self‐stigma caused by PWS affects young patients and their parents. The parents in particular tend to suffer more than their children from perceived and anticipated stigma. Psychological support and early treatment can improve the livelihoods of young patients and their parents.
Nationwide survey (Japan) on spontaneous hemoperitoneum in pregnancy
Authors: Hagimoto Miki , Tanaka Hiroaki , Osuga Yutaka , Miura Kiyonori , Saito Shigeru , Sato Shoji , Sugawara Junichi , Ikeda Tomoaki 
Published: May 2021

AbstractAimThe purpose of this study was to evaluate the current state and clinical characteristics of spontaneous hemoperitoneum in pregnancy (SHiP) in Japan by performing a comprehensive survey.MethodsWe reviewed data on pregnant women who developed SHiP during 2013–2017 (for 5 years), and were admitted to any of the perinatal centers in Japan. The survey assessed maternal background and maternal and neonatal prognosis. We divided the cases into two groups, favorable and poor prognosis groups, and made comparisons between the two groups.ResultsOf the 407 facilities in Japan, 267 (66%) facilities responded to our survey. Overall, 31 cases of SHiP were registered. Maternal death occurred in one case (3%) due to liver bleeding with an unknown cause. Of 23 cases with a SHiP onset during pregnancy, 12 (53%) had been misdiagnosed as placental abruption. The prognosis for the fetuses included miscarriage or stillbirth in three cases (10%) and asphyxia in 12 cases (42%). There was no significant correlation between the amount of intra‐abdominal blood loss and neonatal prognosis based on umbilical artery pH. Incidences of preterm birth <32 gestational weeks (adjusted odds ratio, 35.75; 95% confidence interval, 3.46–368.82) were higher in the poor prognosis group than that in the favorable group. Endometriosis and artificial reproductive techniques were both associated with 19% of all cases of SHiP.ConclusionSHiP was associated with maternal death and poor fetal prognosis. Prematurity and persistent uterine contractions which might be misdiagnosed as placental abruption seem to contribute to poor fetal prognosis.
Toward a Regeneration of Revolutionary Theory
Authors: Abrams Benjamin 
Published: May 2021

AbstractRevolutionary theorists are currently immersed in a critical debate about the future of the field. Allinson has argued that a fifth generation of revolutionary theory has passed us by without our noticing, while I have contended that it is revolutionary theory's fourth generation that is decidedly imperilled. Ritter and Beck – for their part‐ contend that we should reject the very idea of theoretical ‘generations’, and instead think of progress in revolutionary theory as a series of ongoing and settled debates about certain key topics. The pair contend that revolutionary theory has reached a consensus on two core debates: defining our object of study and determining appropriate methods. Contrary to this position, I argue that while there is much to praise about rejecting generational imagery, doing so necessarily entails that we also critique the self‐proclaimed ‘fourth generation' with which such imagery is intertwined. Furthermore, I argue that there does not yet exist consensus among revolutionary theorists about a single definition of revolution, or on the question of which methods to use. Finally, I call for a regeneration of revolutionary theory which moves genuinely beyond the generational mythologies of the past.
Living with thalassaemia in Papua New Guinea, the experience of children, adolescents and their families
Authors: Nagiria Violet Regina , Vince John D , Duke Trevor 
Published: May 2021

AimThalassaemia, the commonest genetic blood disorder in Papua New Guinea (PNG) presents daunting challenges for the affected children, their parents and families, and the health system. We aimed to describe the quality of life of affected children and adolescents and the experience of and difficulties faced by their parents in the setting of a tertiary referral hospital in PNG.MethodsA mixed‐methods longitudinal study involving baseline questionnaire, then serial interviews with parents, children and adolescents living with β‐thalassaemia attending Port Moresby General Hospital.ResultsTwenty‐one patients and their families were interviewed over a 6‐month period. Most families originated outside the National Capital District and had migrated to be near the Port Moresby General Hospital and its blood bank services. Thirteen patients had at least one affected sibling and four families had experienced the death of at least one other affected child. No child was receiving chelating agents, and most had clinical evidence of iron overload. There were important impacts of thalassemia on quality of life, including very poor school attendance and some aspects of children's self‐perception. Families faced significant burdens and made genuine sacrifices to care for their children.ConclusionRegular blood transfusions increase the life‐span of children with thalassaemia but there is a need to achieve a hyper‐transfusion regimen coupled with chelation therapy. As for all chronic illness, a focused and holistic approach is needed to improve the quality of life for affected children and their families.
Another day, another chance: Daily workplace experiences and their impact on creativity
Authors: McKay Alexander S. , Mohan Mayoor , Reina Christopher S. 
Published: May 2021

AbstractCreative climate research shows that an employee's perception of their work environment impacts their creative performance. However, variable‐centered approaches (e.g., moderated regression) are often unable to study all climate factors interacting simultaneously, with researchers only able to focus on a few factors at a time. Further, longitudinal climate research shows these perceptions fluctuate over time. To overcome some limitations of variable‐centered approaches, we use a person‐centered approach with a longitudinal focus to (a) identify distinct daily workplace experience profiles, (b) explore the stability of people's workplace experiences over time, and (c) investigate whether daily workplace experiences relate to creativity. We used an archival dataset of 11,245 daily surveys from 221 people asking about their work environment to identify five daily workplace experience profiles. We find people have varying experiences over the course of a project, but that these experiences also appear to be stable within a one‐week period. Finally, we also found that these experiences influence creative self‐perceptions and creative performance behaviors. As such, this study helps integrate various creativity and organizational theories to develop a rich and more holistic understanding of how daily work environment perceptions impact creative work.
Atypical package design and product category prestige
Authors: Kim Tom Joonhwan , Petitjean Margaux 
Published: May 2021

AbstractInnovation in the design of products has become an important competitive tool of success in the market for many firms (see the virtual issue on Design Innovation in the Journal of Product Innovation Management [2020]). A few firms have had success in the market by adopting innovative designs. But not all innovative designs give success to firms. This research focuses on package design as an important marketing tool of innovation, influencing consumer responses to products. When designing packaging, firms typically follow category‐based visual codes, but they can adopt an innovative design that deviates from the codes, producing atypical package designs. This research shows that the effectiveness of atypical package design depends on product category prestige. Consumers respond to signals about product quality, such as package design, when they believe the signals are credible. When a product category is prestigious, consumers perceive package design as a diagnostic signal. Consumers are more likely to infer high product performance from an atypical package design and choose that product. We compare three dimensions of product design (aesthetics, functionality, and symbolism) to reveal that functionality is the reason why consumers prefer an atypical package design in a prestigious category. A series of studies show that the preference for atypical package design becomes stronger when consumers are choosing products in a prestigious category than in a standard category. The preference for atypical package design is attenuated when other information related to performance is provided, even when the aesthetics and symbolism of atypical package design do not change.
Species‐level ichthyoplankton dynamics for 97 fishes in two major river basins of the Amazon using quantitative metabarcoding
Authors: Mariac Cédric , Renno Jean‐François , Carmen Garcia‐Davila  , Vigouroux Yves , Mejia Eduardo , Angulo Carlos , Castro Ruiz Diana , Estivals Guillain , Nolorbe Christian , García Vasquez Aurea , Nuñez Jesus , Cochonneau Gérard , Flores Mayra , Alvarado Jhon , Vertiz José , Chota‐Macuyama Werner , Sánchez Homero , Miranda Guido , Duponchelle Fabrice 
Published: May 2021

AbstractThe Amazon basin holds the world's largest freshwater fish diversity. Information on the intensity and timing of reproductive ecology of Amazonian fish is scant. We use a metabarcoding method by capture using a single probe to quantify species‐level ichthyoplankton dynamics. We sampled the Marañón and the Ucayali rivers in Peru monthly for 2 years. We identified 97 species that spawned mainly during the flood start, the flood end or the receding periods, although some species had spawning activity in more than one period. This information was new for 40 of the species in the Amazon basin and 80 species in Peru. Most species ceased spawning for a month during a strong hydrological anomaly in January 2016, demonstrating the rapidity with which they react to environmental modifications during the breeding season. We also document another unreported event in the Amazon basin, the inverse phenology of species belonging to one genus (Triportheus). Overall larval flow in the Marañón was more than twice that of the Ucayali, including for most commercial species (between two and 20 times higher), whereas the Ucayali accounts for ~80% of the fisheries landings in the region. Our results are discussed in the light of the main anthropogenic threats to fishes, hydropower dam construction and the Hidrovía Amazónica, and should serve as a pre‐impact baseline.