bluuebunny/crossref_metadata_2025_split huggingface dataset:
Massive MIMO relaying with imperfect RF chains and coarse ADC/DAC in beyond 5G networks
Authors: Wang Meng , Yue Dian‐Wu , Nguyen Ha H. , Jin Si‐Nian 
Published: November 2021

AbstractMassive connectivity, low cost, and energy saving are key requirements in providing Internet of Things (IoT) services in the beyond 5G (B5G) communication networks. Motivated by these requirements, we investigate a massive multiple‐input multiple‐output (MIMO) relaying system with imperfect radio frequency (RF) chains and coarse analog‐to‐digital converters/digital‐to‐analog converters (ADCs/DACs), where IoT user pairs communicate through the assistance of a relay equipped with transceiver antennas in quantity. First, the accurate and the approximate achievable rate expressions are derived in closed form. Then, we evaluate the impacts of critical design parameters on the rate performance. Moreover, scaling laws for transmit powers and RF hardware impairments are established when the number of antennas, M, at the relay grows infinity. It is revealed that, as M increases, the system can yield a non‐vanishing rate while cutting down the transmit powers of the IoT devices and relay, and/or scaling up the RF impairments of the relay. The power allocation scheme for maximizing the sum rate is proposed. Numerical results are conducted to demonstrate the analysis and show that, in the large scale antennas regime, employing high‐quality RF hardware at the IoT users and high‐resolution DACs at the transmit end of the relay can significantly improve the system's sum rate.
Oligodendrocytes regulate the adhesion molecule ICAM‐1 in neuroinflammation
Authors: González‐Alvarado María Nazareth , Aprato Jessica , Baumeister Melissa , Lippert Magdalena , Ekici Arif B. , Kirchner Philipp , Welz Tobias , Hoffmann Alana , Winkler Jürgen , Wegner Michael , Haase Stefanie , Linker Ralf A. 
Published: November 2021

AbstractRecently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize the interaction of Ol with pathogenic T cells. RNA expression analysis revealed an upregulation of immune‐modulatory genes and adhesion molecules (AMs), ICAM‐1 and VCAM‐1, in Ol when isolated from mice undergoing experimental autoimmune encephalomyelitis (EAE). To explore whether AMs are involved in the interaction of Ol with infiltrating T cells, we performed co‐culture studies on mature Ol and Th1 cells. Live cell imaging analysis showed direct interaction between both cell types. Eighty percentage of Th1 cells created contacts with Ol that lasted longer than 15 min, which may be regarded as physiologically relevant. Exposure of Ol to Th1 cells or their supernatant resulted in a significant extension of Ol processes, and upregulation of AMs as well as other immunomodulatory genes. Our observations indicate that blocking of oligodendroglial ICAM‐1 can reduce the number of Th1 cells initially contacting the Ol. These results suggest that AMs may play a role in the interaction between Ol and Th1 cells. We identified Ol interacting with CD4+ cells in vivo in spinal cord tissue of EAE diseased mice indicating that our in vitro findings are of interest to further scientific research in this field. Further characterization and understanding of Ol interaction with infiltrating cells may lead to new therapeutic strategies enhancing Ol protection and remyelination potential. Oligodendrocytes regulate immune modulatory genes and adhesion molecules during autoimmune neuroinflammation Oligodendrocytes interact with Th1 cells in vitro in a physiologically relevant manner Adhesion molecules may be involved in Ol‐Th1 cell interaction.
Natural MHD convection for an impulsively started infinite vertical plate with diffusion‐thermo effect, induced magnetic field, and ramped wall temperature and concentration
Authors: Ahmed Nazibuddin , Gohain Dipunja 
Published: November 2021

AbstractThe major motive of the current investigation is to analyze an exact solution for an unsteady magnetohydrodynamics natural convective flow of a viscous incompressible electrically conducting non‐gray optically thick fluid past an impulsively started infinite vertical plate with ramped wall temperature and concentration in the presence of radiation, diffusion‐thermo effect, and induced magnetic field. Laplace transform method is used to acquire the specific solutions of the dimensionless domain equations. The impact of various physical parameters on fluid velocities, temperature, concentration, and moreover on the rate of heat transfer, mass transfer, and skin friction at the wall are shown graphically. It is also found that the Dufour effect causes an increase in fluid velocity as well as temperature. The ramped condition influences the rise in Nusselt number.
Abdominal hysterectomy and high frailty score are associated with complications among older patients
Authors: Wainger Julia J. , Yazdy Golsa M. , Handa Victoria L. 
Published: November 2021

AbstractObjectiveTo evaluate effects of frailty and hysterectomy route on 30‐day postoperative morbidity for older hysterectomy patients.MethodsParticipants included patients in the American College of Surgeons' National Surgical Quality Improvement Program database aged 60 years or older and undergoing simple hysterectomy from 2014 to 2018. The Five‐Factor Modified Frailty Index approximated frailty: women with scores of 3 or more, indicating more severe comorbidities, were considered frail. Logistic regression multivariable models with and without an interaction term were used to study the independent and interactive effects of frailty and route on postoperative complications.ResultsOf 19 888 hysterectomies, 4356 (21.9%) were abdominal, 13 382 (67%) were laparoscopic, and 2150 (10.8%) were vaginal, with 251 (1.3%) frail patients. Frailty (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.32–2.70, P = 0.001) and abdominal versus laparoscopic hysterectomy (OR 2.14, 95% CI 1.88–2.45, P < 0.001) increased complication odds. Assessing interaction, complication odds for abdominal versus laparoscopic hysterectomy were higher for frail patients (OR 4.12, 95% CI 1.96–8.67, P < 0.001) versus non‐frail patients (OR 2.10, 95% CI 1.84–2.40).ConclusionFrail older patients have increased risk for hysterectomy complications, especially with abdominal hysterectomy versus laparoscopic hysterectomy. A frailty index can be a useful preoperative tool to guide counseling and route choice.
Risk of Bleeding Associated With Nonsteroidal Anti‐inflammatory Drug Use in Patients Exposed to Antithrombotic Therapy: A Case‐Crossover Study
Authors: Paternoster Morgane , Steichen Olivier , Lapeyre‐Mestre Maryse , Blanchon Thierry , Rossignol Louise , Vilcu Ana‐Maria , Launay Titouan , Sarazin Marianne , Bagheri Haleh , Conte Cécile , Turbelin Clément , Hanslik Thomas , Souty Cécile 
Published: November 2021

AbstractConcomitant nonsteroidal anti‐inflammatory drug (NSAIDs) and antithrombotic drug use is associated with an increased risk of bleeding, mainly gastrointestinal. The goal of this study was to quantify the transient increase in the risk of hospitalization for bleeding associated with NSAID use in patients treated with antiplatelet agents or anticoagulants. We performed a unidirectional case‐crossover study using the EGB (Échantillon généraliste de bénéficiaires), a permanent random sample of the French nationwide health database. Patients receiving antithrombotic therapy and hospitalized for bleeding between 2009 and 2017 were included. We compared their NSAID exposure during a 15‐day hazard window immediately before hospital admission to 3 earlier 15‐day control windows. The risk of hospitalization for bleeding associated with the recent use of NSAIDs was estimated using conditional logistic regression to estimate odds ratios (ORs). During the study period, 33 patients treated with anticoagulants and 253 treated with antiplatelet agents received NSAIDs and were included in the case‐crossover analysis. We found an increased risk of hospitalization for gastrointestinal bleeding after exposure to NSAIDs, with an adjusted OR of 3.59 (95%CI, 1.58‐8.17) in patients receiving anticoagulant therapy and 1.44 (95%CI, 1.07‐1.94) in patients receiving antiplatelet therapy. The risk of nongastrointestinal bleeding was also increased after exposure to NSAIDs with an adjusted OR of 2.72 (95%CI, 1.23‐6.04) in patients exposed to anticoagulant therapy. The risk of gastrointestinal and nongastrointestinal bleeding increases after NSAID use in patients treated with anticoagulants, while the risk of gastrointestinal bleeding increases, but to a lesser extent in those treated with antiplatelets.
Association between gestational diabetes mellitus and periodontitis via the effect of reactive oxygen species in peripheral blood cells
Authors: Bunpeng Nattawan , Boriboonhirunsarn Dittakarn , Boriboonhirunsarn Chatkoew , Sawangpanyangkura Teerat , Tansriratanawong Kallapat 
Published: November 2021

AbstractBackgroundPeriodontitis (P) has emerged as a risk factor for gestational diabetes mellitus (GDM) through immune cell function alterations, elevated proinflammatory mediators, and increased reactive oxygen species (ROS). The main objective of present study was to determine associations between pregnancy with and without GDM and P. The secondary objective was to compare ROS production in peripheral blood cells (PBCs) of pregnant women with and without GDM.MethodsThis cross‐sectional case‐control study included 128 pregnant women: 64 with and 64 without GDM. All participants were examined for clinical parameters of GDM and periodontal conditions. Associations between GDM‐related periodontal data and GDM risk were evaluated by multiple logistic regression. PBCs were isolated and cultured. ROS productions in each PBCs types was investigated by flow cytometry with ROS antibodies.ResultsP was significantly more prevalent in pregnant women with GDM than in those without GDM (57.8% versus 37.5%), with an odds ratio (OR) of 2.28, and a 95% confidence interval (CI) of 1.12 to 4.64 (P = 0.022). The OR (95% CI) was 2.59 (1.19 to 5.65) (P = 0.017) after adjusting for potential confounding factors, including diabetes mellitus (DM) family history, age ≥30 years, body mass index, and maternal age. ROS levels in all PBCs types were significantly higher in the GDM than in the non‐GDM group (P < 0.05).ConclusionThis study supported the association between P and GDM and indicated that P may be a risk factor for GDM. High levels of ROS production in the PBCs of pregnant women with GDM emphasized the association with GDM.
Deep‐frying oil induces cytotoxicity, inflammation and apoptosis on intestinal epithelial cells
Authors: Li Xue , Nian Bin‐Bin , Tan Chin‐Ping , Liu Yuan‐Fa , Xu Yong‐Jiang 
Published: November 2021

AbstractBACKGROUNDDeep‐frying oil has been found to cause inflammatory bowel disease (IBD). However, the molecular mechanism of the effect of deep‐frying palm oil on IBD still remains undetermined.RESULTSIn the present study, bioinformatics and cell biology were used to investigate the functions and signal pathway enrichments of differentially expressed genes. The bioinformatics analysis of three original microarray datasets (GSE73661, GSE75214 and GSE126124) in the NCBI‐Gene Expression Omnibus database showed 17 down‐regulated genes (logFC < 0) and 2 up‐regulated genes (logFC > 0) existed in the enteritis tissue. Meanwhile, pathway enrichment and protein–protein interaction network analysis suggested that IBD is relevant to cytotoxicity, inflammation and apoptosis. Furthermore, Caco‐2 cells were treated with the main oxidation products of deep‐frying oil‐total polar compounds (TPC) and its components (polymerized triglyceride, oxidized triglycerides and triglyceride degradation products) isolated from deep‐frying oil. The flow cytometry experiment revealed that TPC and its components could induce apoptosis, especially for oxidized triglyceride. A quantitative polymerase chain reaction analysis demonstrated that TPC and its component could induce Caco‐2 cell apoptosis through AQP8/CXCL1/TNIP3/IL‐1.CONCLUSIONThe present study provides fundamental knowledge for understanding the effects of deep‐frying oils on the cytotoxic and inflammatory of Caco‐2 cells, in addition to clarifying the molecular function mechanism of deep‐frying oil in IBD. © 2021 Society of Chemical Industry.
Quilting following mastectomy reduces seroma, associated complications and health care consumption without impairing patient comfort
Authors: van Zeelst Lotte J. , ten Wolde Britt , van Eekeren Ramon R. J. P. , Volders José H. , de Wilt Johannes H. W. , Strobbe Luc J. A. 
Published: November 2021

AbstractBackgroundAn important complication following mastectomy is seroma formation. Quilting, in which skin flaps are sutured to the underlying muscle, is reported to reduce seroma incidence, but might induce pain and impair shoulder function. Main objective is to compare quilting with conventional wound closure, regarding seroma incidence, health care consumption, and patient discomfort.MethodsIn a combined prospective and retrospective study, 254 patients undergoing mastectomy and/or axillary lymph node dissection (ALND) were included. Patients received quilting sutures or conventional closure. Primary outcome was clinical significant seroma (CSS). In prospectively included patients shoulder function and analgesic use was observed.ResultsCSS incidence was 12.9% in the quilted versus 62.3% in the nonquilted cohort (p < 0.001). Surgical site infections were reported significantly less in the quilted cohort. Duration of hospital stay was shorter and outpatient clinic visits were less in the quilted cohort. Surgical procedure required 10 additional minutes for quilting. No significant differences were observed in postoperative shoulder function and analgesic use.ConclusionQuilting following mastectomy reduces CSS incidence. Quilting requires 10 additional minutes during surgery. It facilitates day treatment and results in less additional outpatient clinic visits culminating in reduced health care consumption. Shoulder function and pain are not affected by quilting.
A population‐based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet)
Authors: Conway Kristin M. , Gedlinske Amber , Mathews Katherine D. , Perlman Seth , Johnson Nicholas , Butterfield Russell , Hung Man , Bounsanga Jerry , Matthews Dennis , Oleszek Joyce , Romitti Paul A. 
Published: November 2021

AbstractIntroduction/AimsScoliosis is a common comorbidity among individuals diagnosed with a dystrophinopathy. We examined associations between clinical predictors and scoliosis in childhood‐onset dystrophinopathy.MethodsThe progression and treatment of scoliosis were obtained from data collected by the US population‐based Muscular Dystrophy Surveillance, Tracking, and Research Network. Associations between loss of independent ambulation (LoA) and corticosteroid use and scoliosis outcomes (ages at or exceeding Cobb angle thresholds [10°, 20°, 30°]; surgery) were estimated using Kaplan–Meier curve estimation and extended Cox regression modeling.ResultsWe analyzed curvature data for 513 of 1054 individuals ascertained. Overall, approximately one‐half had at least one radiograph and one‐quarter had a curvature of at least 20°. The average maximum curvature was 25.0° (SD = 21.5°) among all individuals and 42.8° (SD = 18.8°) among those recommended for surgery. Higher adjusted hazards ratio of curvature (aHR(curvature) [95% confidence interval]) were found among individuals with LoA compared to those without LoA (aHR(10) = 6.2 [4.4, 8.7], aHR(20) = 15.3 [7.4, 31.7], aHR(30) = 31.6 [7.7, 128.9]), among individuals who did not use corticosteroids compared to those who did (aHR(10) = 1.2 [0.9, 1.7], aHR(20) = 1.8 [1.1, 2.7], aHR(30) = 2.3 [1.3, 4.0]), and among non‐ambulatory individuals who used corticosteroids after LoA compared to those who did not (aHR(10) = 1.8 [1.2, 2.8], aHR(20) = 1.6 [1.0, 2.6], aHR(30) = 3.6 [1.6, 7.9]). Scoliosis surgery among individuals with LoA who did not use corticosteroids was more than double compared to those who used (aHR = 2.3 [1.3, 4.2]).DiscussionOur retrospective observational study suggests corticosteroids may delay spinal curvature progression and need for scoliosis surgery. Continuing corticosteroids after LoA also showed potential benefits of delaying curvature progression, additional studies are needed to confirm this finding or address the magnitude of benefit.
Four‐dimensional ultrasound biometry following botulinum toxin type A injection to the pelvic floor
Authors: Nesbitt‐Hawes Erin M. , Dietz Hans Peter , Ledger William L. , Abbott Jason A. 
Published: November 2021

AbstractAimsThe objective of this study was to provide follow‐up data on four‐dimensional ultrasound (4DUS) morphometry for women having botulinum toxin type A (BoNT‐A) treatment of pelvic floor tension myalgia (PFTM).Materials and MethodsA prospective cohort study was performed from October 2013 to June 2018, recruiting women scheduled for BoNT‐A injection in the pelvic floor musculature. Translabial 4DUS, vaginal pressure assessment by manometry and pain visual analog scales (VAS) were performed on all women before injection and again at 4, 12, and 26 weeks. The BoNT‐A injection was performed under 4DUS guidance.ResultsTwenty‐nine women had 44 injections over the course of the study. Although improvements were seen in VAS scores for dysmenorrhea, nonmenstrual pelvic pain, and dyspareunia, there were no significant differences in ultrasound biometry at either rest, Valsalva, or on contraction when comparing postinjection measurements at 4, 12, and 26 weeks with pre‐injection baseline. Similarly, vaginal pressure readings at rest demonstrated a significant improvement throughout the 4, 12, and 26 week follow‐up, with a reduction in maximal contraction at 4 and 12 but not 26 weeks.ConclusionsThis study demonstrates that 4DUS biometry of the pelvic floor does not correlate with clinical pain and vaginal pressure outcomes for BoNT‐A injection in the context of PFTM.
An augmenting‐flow algorithm for a class of node‐capacitated maximum flow problems
Authors: Curry Robert M. , Smith J. Cole 
Published: November 2021

AbstractWe consider a class of maximum flow problems (MFPs) having node‐ and arc‐capacity constraints, in which each unit of flow on arcconsumes a positive amount of capacity at nodei. This problem arises in wireless sensor network optimization applications, where node capacities refer to sensor energy limits. This version of the MFP is traditionally solved using linear programming due to the presence of the complicating node‐capacity constraints. As an alternative scheme, we prescribe an approach for this problem based on augmenting flows along paths and cycles, showing why sending flows on augmenting cycles becomes necessary in this class of problems. Although our augmenting flow algorithm ultimately requires the solution of auxiliary linear programs, we demonstrate the computational advantages of our approach on randomly generated test instances.
Inverting the Parameters of RDD Explosion Source Based on Temporal and Spatial Distribution of Explosion Cloud
Authors: Duan Zhong‐Shan , Lin Yuan‐Ye , Wu Ya‐Li , Feng Xiao‐Jie , Gong Ming‐Fu , Guo Hui‐Ping , Lv Jin‐Xu 
Published: November 2021

AbstractIn order to invert the explosion equivalent and cloud top height of “Radiological Dispersal Device”(RDD) by cloud distribution, we firstly analyzed the temporal and spatial distribution of the cloud uplift of explosive experiments and revealed that the height of the explosion cloud increased with time according to a power function and this relationship was of certain stability. Based on the computational fluid dynamics (CFD) simulations and experimental proof, we further characterized cloud distribution of 12 TNT explosions, analyzed the diffusion patterns and parameters change of the cloud, and established a calculation model of cloud top height and equivalent of a radiological dispersal device by fitting. Finally, a calculation model for the inversion of explosion equivalent and height based on the temporal and spatial parameters of the cloud was constructed using the generalized regression neural network (GRNN) data‐driven algorithm, and verified by six different explosion tests with different equivalent. The results showed the explosion equivalent and height could be quickly inverted by combining the high dynamic information of the explosion cloud at the visual stage with the nonlinear regression mathematical method. The average error of the inverted explosion equivalent and height were 12.3 % and 7.1 % respectively compared with the experimental ones, indicating that the calculation model can be used for off‐site rapid detection, early warning and evaluation of unknown explosion source.
Using Surface Grooves on Propellant Grain to Control the Erosive Burning in Solid Rocket Motors
Authors: Mahdi Tahsini Amir , Karam Ghareh Gheshlaghi Maziar , Razzaghi Behrooz 
Published: November 2021

AbstractThis paper aims to introduce a new technique to eliminate the erosive burning phenomenon in solid rocket motors. The erosive burning which occurs in motors with high volumetric loadings and small port to throat area ratios, has some disadvantages like an early phase over‐pressure and exposing the rocket chamber casing by hot combustion gas flows. The innovative simple practical method is based on the geometrical treatment of the propellant grain, locating some grooves on the surface at its aft‐end, to reduce the rate of the heat transfer into the burning surface where the erosive burning is likely to occur. The numerical analysis of the flow on the grooved wall is utilized to physically explain the correctness of this idea, and the quasi‐one‐dimensional simulation of the internal ballistics of the solid rocket motor is performed to demonstrate the effect of grooves on the performance map of the motor. The results show that by using this suggested simple technique, the designer can eliminate the erosive burning and improve the motor‘s performance maps.