bluuebunny/crossref_metadata_2025_split huggingface dataset:
The new concept of quality in the digital era: a human resource empowerment perspective
Authors: Balouei Jamkhaneh Hadi , Shahin Arash , Parkouhi Sahar Valipour , Shahin Reza 
Published: August 2021

PurposeThis study aims to identify the drivers of human resource empowerment in understanding the new concept of Quality 4.0 in the digital era.Design/methodology/approachFirst, the literature of quality management evolution in the fourth industrial revolution (Industry 4.0) and the position of the required workforce in Quality 4.0 were reviewed and then by using the opinions of experts and managers of Knowledge-Intensive Business Services (KIBS) firms, a set of driver effects on the readiness and ability of human resources was identified in the context of Quality 4.0. After identifying the drivers, cause-and-effect relationships among these drivers were investigated using the Grey DEMATEL technique.FindingsA total of 29 Quality 4.0 drivers of readiness and workforce ability were identified, based on multiple interactions of quality management in different stages of the production cycle. They were divided into new valuation approaches, composite dimensions, team creativity and thorough inspection. “Technical abilities and capability to solve problems” was identified as the most significant driver.Practical implicationsFindings help KIBS firms to take necessary measures and plans. Consequently, they can increase the readiness and ability of human resources based on the changes in managing Quality 4.0. Also, considering the importance of each driver, they will be able to take a step towards total quality improvement.Originality/valueDespite extensive research on the subject of the fourth Industrial Revolution, research on the human aspects required for managing Quality 4.0 is limited. This study was performed to examine the cause-and-effect relationships between human resource drivers to adapt to the changes in Quality 4.0.
Viable but non‐cultivable state: a strategy for Staphylococcus aureus survivable in dual‐species biofilms with Pseudomonas aeruginosa?
Authors: Magalhães Andreia Patrícia , Grainha Tânia , Sousa Ana Margarida , França Ângela , Cerca Nuno , Pereira Maria Olívia 
Published: August 2021

SummaryPseudomonas aeruginosa and Staphylococcus aureus are two of the most prevalent respiratory pathogens in cystic fibrosis patients. Both organisms often cause chronic and recalcitrant infections, in large part due to their ability to form biofilms, being these mixed‐species infections correlated with poor clinical outcomes. In this study, the hypothesis that S. aureus adopts phenotypes allowing its coexistence with P. aeruginosa during biofilm growth was put forward. We noticed that S. aureus undergoes a viable but non‐cultivable (VBNC) state in the dominated P. aeruginosa dual‐species consortia, whatsoever the strains used to form the biofilms. Moreover, an increased expression of genes associated with S. aureus virulence was detected suggesting that the phenotypic switching to VBNC state might account for S. aureus pathogenicity and, in turn, influence the clinical outcome of the mixed‐species infection. Thus, P. aeruginosa seems to induce both phenotypic and transcriptomic changes in S. aureus, helping its survival and coexistence in the dual‐species biofilms. Overall, our findings illustrate how interspecies interactions can modulate bacterial virulence in vitro, contributing to a better understanding of the behaviour of P. aeruginosa–S. aureus dual‐species biofilms.
PP‐1β and PP‐2Aα modulate cAMP response element‐binding protein (CREB) functions in aging control and stress response through de‐regulation of αB‐crystallin gene and p300‐p53 signaling axis
Authors: Wang Ling , Zhang Lan , Gong Xiao‐Dong , Fu Jia‐Ling , Gan Yu‐Wen , Hou Min , Nie Qian , Xiang Jia‐Wen , Xiao Yuan , Wang Yan , Zheng Shu‐Yu , Yang Lan , Chen Huimin , Xiang Meng‐Qing , Liu Yizhi , Li David Wan‐Cheng 
Published: August 2021

AbstractThe function of the transcription factor, cAMP response element‐binding protein (CREB), is activated through S133 phosphorylation by PKA and others. Regarding its inactivation, it is not well defined. cAMP response element‐binding protein plays an essential role in promoting cell proliferation, neuronal survival and the synaptic plasticity associated with long‐term memory. Our recent studies have shown that CREB is an important player in mediating stress response. Here, we have demonstrated that CREB regulates aging process through suppression of αB‐crystallin and activation of the p300‐p53‐Bak/Bax signaling axis. First, we determined that two specific protein phosphatases, PP‐1β and PP‐2Aα, can inactivate CREB through S133 dephosphorylation. Subsequently, we demonstrated that cells expressing the S133A‐CREB, a mutant mimicking constant dephosphorylation at S133, suppress CREB functions in aging control and stress response. Mechanistically, S133A‐CREB not only significantly suppresses CREB control of αB‐crystallin gene, but also represses CREB‐mediated activation of p53 acetylation and downstream Bak/Bax genes. cAMP response element‐binding protein suppression of αB‐crystallin and its activation of p53 acetylation are major molecular events observed in human cataractous lenses of different age groups. Together, our results demonstrate that PP‐1β and PP‐2Aα modulate CREB functions in aging control and stress response through de‐regulation of αB‐crystallin gene and p300‐p53‐Bax/Bak signaling axis, which regulates human cataractogenesis in the aging lens.
The impact of COVID‐19 on the sensitivity of D‐dimer for pulmonary embolism
Authors: Elberts Samuel J. , Bateman Ryan , Koutsoubis Alexandra , London Kory S. , White Jennifer L. , Fields J. Matthew 
Published: August 2021

AbstractObjectiveThis study seeks to evaluate the test characteristics of D‐dimer for pulmonary embolism (PE) in patients with a concurrent diagnosis of COVID‐19. We hypothesized that the sensitivity of D‐dimer for PE at current institutional cut points would be similar to those without COVID‐19.MethodsThis is a multicenter retrospective observational cohort study across five urban and suburban EDs in the same health care system. The electronic health record was queried for all computed tomography pulmonary angiography (CTPA) studies from December 1, 2019, to October 22, 2020. All ED patients who underwent CTPA had D‐dimer and COVID‐19 testing completed in a single encounter were included in the study. Baseline demographics were obtained. Test characteristics of D‐dimer for PE were calculated for patients with and without COVID‐19. Additionally, receiver operator characteristics (ROC) curves were constructed for two different D‐dimer assays.ResultsThere were 1158 patient encounters that met criteria for analysis. Performance of D‐dimer testing for PE was similar between COVID‐19–positive and –negative patients. In COVID‐19–positive patients, the sensitivity was 100% (95% confidence interval [CI] = 87.6%–100%), specificity was 11.9% (95% CI = 7.9%–17.1%), and negative predictive value (NPV) was 100%. In COVID‐19–negative patients the sensitivity was 97.6% (95% CI = 91.5%–99.7%), specificity was 14.4% (95% CI = 12.1%–17%), and NPV was 98.3% (95% CI = 93.8%–99.6%). For assay 1 the area under the curve (AUC) for COVID‐19–positive patients was 0.76 (95% CI = 0.68–0.83), and for COVID‐19–negative patients, 0.73 (95% CI = 0.69–0.77). For assay 2, AUC for COVID‐19–positive patients was 0.85 (95% CI = 0.77–0.92), and for COVID‐19–negative patients, 0.80 (95% CI = 0.77–0.84). Inspection of the ROC curve for assay 1 revealed that 100% sensitivity was maintained up to a threshold of 0.67 FEU (fibrinogen equivalent units; from 0.50 FEU) with an increase in specificity to 29% (from 18.7%), and for assay 2, 100% sensitivity was maintained up to a threshold of 662 D‐dimer units (DDU; from 230 DDU) with an increased specificity to 59% (from 6.1%).ConclusionResults from this multicenter retrospective study did not find a significant difference in sensitivity of D‐dimer for PE due to concomitant COVID‐19 infection. Further study is required to determine if PE can safely be excluded based on D‐dimer results alone in patients with suspected or proven COVID‐19 or if adjusted D‐dimer levels could have a role in management.
Letter: the diagnostic and prognostic significance of liver histology in alcoholic hepatitis
Authors: Vaz Karl , McLean Catriona , Majeed Ammar , Little Robert , Kemp William , Roberts Stuart 
Published: August 2021

LINKED CONTENTThis article is linked to Forrest et al and Forrest & Goldin papers. To view these articles, visit https://doi.org/10.1111/apt.16157 and https://doi.org/10.1111/apt.16559
Chronic stress experience, sleep, and physical activity: Relations with change in negative affect and acute stress response to a naturalistic stressor
Authors: Nordberg Hannah , Kroll Juliet L. , Rosenfield David , Chmielewski Michael , Ritz Thomas 
Published: August 2021

ObjectivesPrior research indicates that chronic stress increases allostatic load and alters individuals’ affective response to stress. Recent studies have linked health‐related behaviours including poor sleep and physical inactivity with elevated negative affect responses to stress. This study extends prior work to investigate chronic stress experience, sleep, and physical activity as predictors of negative affect and acute stress experience during acute, sustained naturalistic stress.DesignStudents (N = 637) were assessed during an academic semester and end‐of‐term final exam period.MethodsSelf‐report ratings of chronic stress experience, negative affect, acute stress experience, sleep, physical activity, demographics, and health were obtained. Hierarchical multiple regression analyses examined the extent to which chronic stress experience, sleep duration and sleep quality, habitual physical activity, and their interactions, predicted changes in negative affect and acute stress experience during final exams. Health‐related behaviours were also examined as mediators between chronic stress experience and changes in negative affect and acute stress experience.ResultsGreater chronic stress experience and shorter exam period sleep duration, but not habitual sleep duration or physical activity, predicted greater increases in negative affect and acute stress experience. Poorer overall sleep quality was a significant predictor in these models and partially mediated the relation between chronic stress experience and negative affect and acute stress experience.ConclusionsFindings highlight the importance of chronic stress experience and sleep in predicting individuals’ affective health during naturalistic stress. Interventions that reduce chronic stress experience and improve sleep may help individuals’ buffer against impairments to affective health during these episodes.
Normal‐Driven Spherical Shape Analogies
Authors: Liu Hsueh‐Ti Derek , Jacobson Alec 
Published: August 2021

AbstractThis paper introduces a new method to stylize 3D geometry. The key observation is that the surface normal is an effective instrument to capture different geometric styles. Centered around this observation, we cast stylization as a shape analogy problem, where the analogy relationship is defined on the surface normal. This formulation can deform a 3D shape into different styles within a single framework. One can plug‐and‐play different target styles by providing an exemplar shape or an energy‐based style description (e.g., developable surfaces). Our surface stylization methodology enables Normal Captures as a geometric counterpart to material captures (MatCaps) used in rendering, and the prototypical concept of Spherical Shape Analogies as a geometric counterpart to image analogies in image processing.
Learning Direction Fields for Quad Mesh Generation
Authors: Dielen Alexander , Lim Isaak , Lyon Max , Kobbelt Leif 
Published: August 2021

AbstractState of the art quadrangulation methods are able to reliably and robustly convert triangle meshes into quad meshes. Most of these methods rely on a dense direction field that is used to align a parametrization from which a quad mesh can be extracted. In this context, the aforementioned direction field is of particular importance, as it plays a key role in determining the structure of the generated quad mesh. If there are no user‐provided directions available, the direction field is usually interpolated from a subset of principal curvature directions. To this end, a number of heuristics that aim to identify significant surface regions have been proposed. Unfortunately, the resulting fields often fail to capture the structure found in meshes created by human experts. This is due to the fact that experienced designers can leverage their domain knowledge in order to optimize a mesh for a specific application. In the context of physics simulation, for example, a designer might prefer an alignment and local refinement that facilitates a more accurate numerical simulation. Similarly, a character artist may prefer an alignment that makes the resulting mesh easier to animate. Crucially, this higher level domain knowledge cannot be easily extracted from local curvature information alone. Motivated by this issue, we propose a data‐driven approach to the computation of direction fields that allows us to mimic the structure found in existing meshes, which could originate from human experts or other sources. More specifically, we make use of a neural network that aggregates global and local shape information in order to compute a direction field that can be used to guide a parametrization‐based quad meshing method. Our approach is a first step towards addressing this challenging problem with a fully automatic learning‐based method. We show that compared to classical techniques our data‐driven approach combined with a robust model‐driven method, is able to produce results that more closely exhibit the ground truth structure of a synthetic dataset (i.e. a manually designed quad mesh template fitted to a variety of human body types in a set of different poses).
Surface Map Homology Inference
Authors: Born J. , Schmidt P. , Campen M. , Kobbelt L. 
Published: August 2021

AbstractA homeomorphism between two surfaces not only defines a (continuous and bijective) geometric correspondence of points but also (by implication) an identification of topological features, i.e. handles and tunnels, and how the map twists around them. However, in practice, surface maps are often encoded via sparse correspondences or fuzzy representations that merely approximate a homeomorphism and are therefore inherently ambiguous about map topology. In this work, we show a way to infer topological information from an imperfect input map between two shapes. In particular, we compute a homology map, a linear map that transports homology classes of cycles from one surface to the other, subject to a global consistency constraint. Our inference robustly handles imperfect (e.g., partial, sparse, fuzzy, noisy, outlier‐ridden, non‐injective) input maps and is guaranteed to produce homology maps that are compatible with true homeomorphisms between the input shapes. Homology maps inferred by our method can be directly used to transfer homological information between shapes, or serve as foundation for the construction of a proper homeomorphism guided by the input map, e.g., via compatible surface decomposition.
The Diamond Laplace for Polygonal and Polyhedral Meshes
Authors: Bunge A. , Botsch M. , Alexa M. 
Published: August 2021

AbstractWe introduce a construction for discrete gradient operators that can be directly applied to arbitrary polygonal surface as well as polyhedral volume meshes. The main idea is to associate the gradient of functions defined at vertices of the mesh with diamonds: the region spanned by a dual edge together with its corresponding primal element — an edge for surface meshes and a face for volumetric meshes. We call the operator resulting from taking the divergence of the gradientDiamondLaplacian. Additional vertices used for the construction are represented as affine combinations of the original vertices, so that the Laplacian operator maps from values at vertices to values at vertices, as is common in geometry processing applications. The construction is local, exactly the same for all types of meshes, and results in a symmetric negative definite operator with linear precision. We show that the accuracy of the Diamond Laplacian is similar or better compared to other discretizations. The greater versatility and generally good behavior come at the expense of an increase in the number of non‐zero coefficients that depends on the degree of the mesh elements.
Policing Race and Performing State Power: Immigration Enforcement and Undocumented Latinx Immigrant Precarity in Central Florida
Authors: Kline Nolan 
Published: August 2021

AbstractIn the United States, undocumented Latinx immigrants’ precarious social positions are rooted in aggressive immigration enforcement practices that create a contestant threat of detection and deportation. This threat extends into the US interior, and in some US cities, immigrant policing practices rely on law enforcement officers racially profiling Latinx immigrants. Several social scientists have described the numerous consequences of racially‐based immigrant policing, but insufficient scholarship examines the role urban and suburban spaces play in constructing the policing regimes that structure undocumented immigrants’ precarity. In this article, I examine the relationship between immigration enforcement regimes, automobiles, and the suburban roadways in a previously rural Central Florida exurb. Using frameworks of automobility, illegality, and necropolitics, I show how Central Florida’s expanding suburban infrastructure contributes to immigrant policing efforts. I further show how spectacles of immigration enforcement, such as parking border patrol vehicles along specific highways, are performances of state power to reinforce racial hierarchies. Overall, I argue that spatial and material conditions—such as driving vehicles that law enforcement officers associate with undocumented immigrants on specific roadways—serve to simultaneously underscore undocumented immigrants’ vulnerability and to signal to white residents how law enforcement officers maintain white supremacy by targeting undocumented Latinx drivers.
Augmentation stability and early wound healing outcomes of guided bone regeneration in peri‐implant dehiscence defects with L‐ and I‐shaped soft block bone substitutes: A clinical and radiographic study
Authors: Jung Eun‐Hee , Jeong Seong‐Nyum , Lee Jae‐Hong 
Published: August 2021

AbstractObjectivesTo retrospectively evaluate whether guided bone regeneration (GBR) with L‐ and I‐shaped demineralized bovine bone mineral with 10% collagen (DBBM‐C) differs from GBR with DBBM in terms of augmentation stability and early wound healing outcomes in peri‐implant dehiscence defects.MethodsA total of 91 peri‐implant defects were grafted with 24 L‐ (GBR‐L), 22 I (GBR‐I)‐shaped DBBM‐C, and 45 DBBM (GBR‐P). Cone‐beam computed tomography images were obtained after surgery and at 5 months follow‐up. The horizontal thickness (HT0, HT2, HT4), vertical thickness (VT), and VT at 45° angle (45‐VT) of the augmented hard tissue were measured. Early postoperative discomfort and wound healing outcomes were assessed 2 weeks after surgery, and periotest values were also measured at 5 months in all groups.ResultsAt 5 months follow‐up, the change at HT0 and VT of the GBR‐L (HT0: −0.63 ± 0.55 mm, VT: −0.77 ± 0.60 mm) and GBR‐I (HT0: −0.68 ± 0.53 mm, VT: −0.91 ± 0.73 mm) groups was significantly more stable than that of the GBR‐P (HT0: −1.30 ± 0.77 mm, VT: −1.57 ± 0.67 mm) group (p < .05). The GBR‐L group (−0.74 ± 0.54 mm) showed better augmentation stability than the other two groups at the change at 45‐VT. Early postoperative discomfort, wound healing outcomes, and periotest values did not differ significantly between the three groups.ConclusionWithin the limitations of this study, L‐ and I‐shaped DBBM‐Cs used for GBR were more beneficial in terms of horizontal augmentation stability than DBBM after a 5‐month healing period.
SLCO1B1 *15 allele is associated with methotrexate‐induced nausea in pediatric patients with inflammatory bowel disease
Authors: Mehta Rishi S. , Taylor Zachary L. , Martin Lisa J. , Rosen Michael J. , Ramsey Laura B. 
Published: August 2021

AbstractLow‐dose methotrexate (MTX) is an immunosuppressant used to treat inflammatory bowel disease (IBD). SLCO1B1 genetic variation has been associated with delayed MTX clearance and increased toxicity. The purpose of this study was to evaluate the association between SLCO1B1 genetic variation and MTX‐induced nausea in children with IBD. We performed a single center retrospective chart analysis of 278 patients who were prescribed MTX for IBD. Two hundred two patients had banked DNA and were genotyped for three SLCO1B1 single nucleotide polymorphisms (SNPs; rs4149056, rs2306283, and rs11045819). Diplotypes were determined by combining the SNPs into *1, *4, *5, *14, *15, and *37 alleles. Incidence of nausea was abstracted from clinician notes. Prescriptions and demographics were extracted from the medical record. The cohort was 69.8% boys, 89.1% White, and 87.6% had a diagnosis of Crohn’s disease with a mean age of 16.0 (± 3.8) years. MTX‐induced nausea was noted in 34% of the cohort. MTX‐induced nausea was associated with the number of reduced‐function *15 alleles (p = 0.034) and occurred 2.26 times more often in patients with at least one *15 allele who did not initiate MTX treatment with concomitant ondansetron (p = 0.034). MTX‐induced nausea was significantly independently associated with SLCO1B1 diplotype (p = 0.006) after controlling for MTX dose group and concomitant ondansetron. Our data demonstrate that the SLCO1B1 *15 allele is associated with MTX‐induced nausea in pediatric patients with IBD. Additionally, *15 allele carriers could benefit from a dose reduction of MTX to reduce exposure and treatment initiation with concomitant ondansetron to reduce nausea.
Giant benign lymphangioendothelioma with positive expression of Wilms tumor 1: A case report
Authors: Teixeira Diogo , Canelhas Áurea , Costa Miguel , Magalhães César , Ferreira Eduarda Osório , César Artur 
Published: August 2021

AbstractBenign lymphangioendothelioma (BL, acquired progressive lymphangioma) is a rare, slow‐growing lymphatic tumor, first described 40 years ago, with fewer than 50 published cases. Clinically, it presents as a skin‐colored or erythematous patch. Definitive diagnosis requires histopathological examination. The immunohistochemical staining profile is still controversial regarding Wilms tumor 1 (WT1) expression, a marker of proliferative and neoplastic, rather than malformative nature. Here, we report a case of a 60‐cm‐long BL on the breast of an adult female. Biopsy revealed irregular vascular spaces dissecting the collagen bundles lined by swollen endothelial cells but without cellular atypia. Positivity for podoplanin (D2‐40), CD31, and WT1 was observed, supporting the neoplastic nature of this lesion. Dermatologists and pathologists must be aware of this entity for early diagnosis and treatment.