bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis
Authors: Baeken Marius W. , Behl Christian 
Published: May 2021

AbstractThe B‐cell CLL 2‐associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and degeneration, BAG3 has exhibited an essential role often related to its capabilities to organize and remove aggregated proteins. Exciting studies in different species ranging from human, murine, zebrafish, and plant samples have delivered vital insights into BAG3s' (and other BAG proteins') functions and their regulations. However, so far no studies have addressed neither BAG3's evolution nor its phylogenetic position in the BAG family.
Diagnostic and therapeutic potencies of miR‐18a‐5p in mixed‐type gastric adenocarcinoma
Authors: Wang Li , Zhang Mingxin , Wang Jiansheng , Zhang Jia 
Published: May 2021

AbstractMixed‐type gastric adenocarcinoma (by Lauren Classification) has poor clinical outcomes with few targeted treatment options. The primary objective of this study was to find the prognostic factors, accurate treatment approaches, and effective postoperative adjuvant therapy strategies for patients with mixed‐type gastric adenocarcinoma (GA). A microRNA sequencing data set and the corresponding clinical parameters of patients with gastric cancer were obtained from The Cancer Genome Atlas. Differentially expressed microRNAs (DEMs) of diffuse‐ and intestinal‐type GA were, respectively, determined. Kaplan–Meier and log‐rank tests were subsequently carried out to evaluate the prognostic relevance of each DEM. To study the common factors between diffuse‐ and intestinal‐type GA, a pathway enrichment analysis was performed on the target genes of identified DEMs using the PANTHER database. After data preprocessing, we analyzed a total of 230 samples from 210 patients with GA. Eighty‐six DEMs in diffuse‐type GA samples and 59 DEMs in intestinal‐type GA samples were, respectively, identified (p  2.0). The Kaplan–Meier survival method further screened out six prognosis‐related DEMs for diffuse‐type GA and seven prognosis‐related DEMs for intestinal‐type GA (p < 0.05). MiR‐18a‐5p was found to be the only common prognosis‐related DEM between diffuse‐ and intestinal‐type GA. The common signaling pathways further revealed that target genes of miR‐18a‐5p are involved in mixed‐type GA progression. This study suggests that miR‐18a‐5p acts as a potential target for treatment, and common signal pathways provide a rich basis to seek reliable and effective molecular targets for the diagnosis, clinical treatment, and postoperative adjuvant therapy strategy of mixed‐type GA.
Prediction of lymph node metastasis in oral tongue squamous cell carcinoma using the neutrophil‐to‐lymphocyte ratio and platelet‐to‐neutrophil ratio
Authors: Wang Bo , Liu Junwen , Zhong Zhengrong 
Published: May 2021

AbstractBackgroundLymph node metastasis in a variety of tumors is associated with systemic inflammatory markers. However, this association has not been reported in oral tongue squamous cell carcinoma (OTSCC). This study aimed to investigate how the preoperative neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐neutrophil ratio (PNR) in OTSCC patients correlated with the occurrence of OTSCC and lymph node metastasis.MethodsThe data of 73 patients with primary OTSCC who underwent surgical resection were retrospectively analyzed. Patients with other malignant tumors, patients who had received radiotherapy or chemotherapy before surgery, and patients with active inflammation were excluded. The enrolled patients were divided into groups N0 (no early‐stage lymph node metastasis) and N1 (early‐stage lymph node metastasis). Venous blood samples were collected before surgery and at the third week after surgery and subjected to complete blood counting in a blood analyzer. Eighty‐seven healthy people were included as a control group. In addition, the NLR and PNR in OTSCC patients were compared with those in the controls, and the postoperative NLR and PNR of group N0 were compared with those of group N1.ResultsThe NLR was significantly higher in the OTSCC patients than the controls (p < 0.05). The area under the receiver operating characteristic curve was 0.595. Further comparison of the NLR and PLR between group N0 and group N1 showed that when NLR was ≤1.622, and the probability of early‐stage lymph node metastasis in OTSCC patients was 73.3%, and when PNR was >60.889, the probability was 86.7%. In re‐examination 3 weeks postoperatively, the NLR and PNR were not significantly different between groups.ConclusionThe NLR has certain reference value for the diagnosis of OTSCC. The preoperative NLR and PNR can be used to predict early‐stage lymph node metastasis in patients with histopathologically confirmed OTSCC.
Microaggressions towards lesbian and transgender women: Biased information gathering when working alongside gender and sexual minorities
Authors: Anzani Annalisa , Sacchi Simona , Prunas Antonio 
Published: May 2021

AbstractObjectiveMicroaggressions, a concept originally introduced for ethnic minorities, represent subtle day‐to‐day discrimination, damaging the psychological health and well‐being of lesbian, gay, bisexual, and transgender individuals as well. This study aimed to assess whether microaggressions occur in psychotherapists’ assessments of clients who identify as either lesbian or transgender woman when compared with those identifying as heterosexual woman.MethodsThe study included a sample of 135 licensed psychotherapists (110 cisgender women and 25 cisgender men). Participants were presented with an audio file of a woman introducing herself during her first therapy session. Three versions were presented: a transgender, a lesbian, and a heterosexual client. Participants were asked to assess the clinical relevance of 10 questions defined as neutral (N = 5) and microaggressive (N = 5), used to determine a clinical impression of the client. A repeated measure analysis of variance was conducted to understand the likelihood of clients of different gender identity and sexual orientation receiving microaggressions.ResultsParticipants were more prone to consider microaggressive questions relevant where the client identified as either lesbian or transgender.ConclusionsThe findings highlighted a bias against lesbian and trans women in evaluating the relevance and usefulness of clinical information while making a psychological assessment of a case.
Pseudomelanosis coli, its relation to laxative use and association with colorectal neoplasms: A comprehensive review
Authors: Mohammed Abdul , Paranji Neethi , Singh Amandeep , Sanaka Madhusudhan R 
Published: May 2021

AbstractPseudomelanosis coli is historically associated with anthraquinone laxatives and is often used as a surrogate marker for chronic laxative use. The opioid epidemic has seen an increase in laxative use for chronic constipation. Anthraquinone laxatives have demonstrated tumorigenic potential in animal studies due to their apoptotic effects on colonic epithelial cells. Colorectal cancer is associated with significant mortality and morbidity worldwide. Human studies have not shown a significant correlation between anthraquinone laxative use, pseudomelanosis coli, and colorectal carcinoma. The characteristic pigmentation of pseudomelanosis also appears to be absent macroscopically and on histology of neoplastic epithelium. However, there appears to be a slightly higher risk of adenoma development. This has been attributed to a higher polyp detection rate during endoscopy on account of the color contrast between the polyp against a darker background of pseudomelanosis.
Gabapentin for acute pain in sickle cell disease: A randomized double‐blinded placebo‐controlled phase II clinical trial
Authors: Puri Latika , Nottage Kerri , Hankins Jane S. , Wang Winfred C. , McGregor Olivia , Gossett Jeffrey M. , Kang Guolian , Anghelescu Doralina L. 
Published: May 2021

AbstractPain in sickle cell disease (SCD) can have a neuropathic component. This randomized phase II double‐blinded placebo‐controlled study evaluated the efficacy of gabapentin in reducing pain and opioid consumption (morphine‐equivalent dose [MED]) during acute vaso‐occlusive crisis (VOC). Of 90 patients aged 1–18 years with VOC pain, 45 were randomized to a single gabapentin dose (15 mg/kg) and 45 to placebo, in addition to standard treatment; 42 and 44 patients were evaluable in the gabapentin and placebo arms, respectively. A decrease in pain of ≥33% was reported in 68% of patients in the gabapentin arm and 60% of those in the placebo arm (one‐sided p = 0.23). The median MED (mg/kg) in the gabapentin (0.12) and placebo arms (0.13) was similar (p = 0.9). However, in the subset of patients with the HbSS genotype (n = 45), the mean (SD) absolute pain score decrease by the time of discharge was significantly greater in the gabapentin arm (5.9 [3.5]) than in the placebo arm (3.6 [3.3]) (p = 0.032). Pain scores in the overall study population were not significantly reduced when gabapentin was added to standard treatment; however, gabapentin benefited individuals with the more severe genotype, HbSS, during acute VOC. Larger, prospective studies are needed to confirm these findings.
One‐Minute Multi‐contrast Echo Planar Brain MRI in Ischemic Stroke: A Retrospective Observational Study of Diagnostic Performance
Authors: Kits Annika , De Luca Francesca , Kolloch Jens , Müller Susanne , Mazya Michael V. , Skare Stefan , Falk Delgado Anna 
Published: May 2021

BackgroundFast multi‐contrast echo planar MRI (EPIMix) has comparable diagnostic performance to standard MRI for detecting brain pathology but its performance in detecting acute cerebral infarctions has not been determined.PurposeTo assess the diagnostic performance of EPIMix for the detection of acute cerebral infarctions.Study TypeRetrospective observational cohort.PopulationOne hundred and seventy‐two consecutive patients with a clinical suspicion of non‐hyperacute ischemic stroke (January 2018 to December 2019).Field Strength and Sequence1.5 T or 3 T. EPIMix ((echo‐planar based: diffusion weighted (DWI), T2*‐weighted, T2‐weighted, T2‐ and T1‐fluid attenuated inversion recovery (FLAIR) images) vs. standard MRI: echo‐planar DWI, echo‐planar T2*‐weighted or susceptibility weighted, turbo spin‐echo T2‐weighted, T2‐ and T1‐FLAIR turbo spin‐echo sequences.AssessmentThree neuroradiologists rated EPIMix and standard MRI on two separate occasions. Incongruent assessments were resolved in consensus with the fourth reader. The ratings included the diagnostic category (acute infarct, normal, and other pathology). Congruent diagnoses together with consensus diagnoses served as the reference standard.Statistical TestsThe diagnostic performance of EPIMix and standard MRI against the reference standard was calculated by the area under the receiver operating characteristic curve (AUC) and compared by DeLong's test. Sensitivity and specificity were determined. Inter‐rater agreements were evaluated by Fleiss's kappa.ResultsOf 172 patients (61 ± 16 years, 103 men), acute infarcts were present in 80/172 (47%), normal findings in 60/172 (35%), and other pathology in 32/172 (19%). Across readers, the AUCs were .94–.95 for EPIMix and .95–.99 for standard MRI, with overlapping 95% CI (P = .02–.18). Inter‐rater agreement for EPIMix was 0.90 and for standard MRI was 0.93. The sensitivity for EPIMix and standard MRI was 88–91% and 91–98%, respectively, while the specificity was 98–100% and 98–99%, both with overlapping 95% CI.ConclusionMulti‐contrast echo planar MRI showed a high but marginally lower diagnostic performance compared to standard MRI for the detection and characterization of acute brain infarct.Level of Evidence3Technical EfficacyStage 2
Impact of bisoprolol transdermal patch on early recurrence during the blanking period after atrial fibrillation ablation
Authors: Suzuki Yuya , Kuroda Masaru , Fujioka Tomoo , Kintsu Masayuki , Noda Tsubasa , Matsumoto Akinori , Kawata Masahito 
Published: May 2021

AbstractBackgroundEarly recurrences of atrial arrhythmias (ERAAs) after ablation may require therapeutic intervention. The optimal medical therapy that prevents ERAAs requires clarification. This study aimed to compare the incidence of ERAAs between patients who received or did not receive bisoprolol transdermal patches (BTPs) at 3 months postablation.MethodsThis single‐center retrospective study enrolled 203 consecutive patients with paroxysmal atrial fibrillation (AF) who had undergone their first ablation, comprising 59 in the BTP group and 144 in the non‐BTP group. Follow‐up assessments were conducted monthly for 3 months. We evaluated the incidence of ERAAs.ResultsDuring the initial 1‐week observational period, the rate of ERAAs was lower in the BTP group (5.0%) than that in the non‐BTP group (18.8%) (P = .013). At 3 months postablation, the rate of ERAAs was lower in the BTP group (6.8%) than that in the non‐BTP group (25.7%) (P = .002). The cumulative freedom from ERAAs was significantly lower in the BTP group than in the non‐BTP group (log‐rank: P = .003). Administering BTPs was an independent factor that protected against ERAAs (odds ratio 0.181, [95% confidence interval 0.059‐0.559], P = .003).ConclusionBTPs may prevent ERAAs after ablation.
Divergent changes of the elevational synchronicity in vegetation spring phenology in North China from 2001 to 2017 in connection with variations in chilling
Authors: Dai Junhu , Zhu Mengyao , Mao Wei , Liu Ronggao , Wang Huanjiong , Alatalo Juha Mikael , Tao Zexing , Ge Quansheng 
Published: May 2021

AbstractMountain ecosystems are sensitive to climate change, and vegetation phenology provides one of the best signals to exemplify ecosystem responses to climate change. Vegetation phenology of mountain ecosystems is usually characterized with an elevational pattern, with the growing season starts earlier and ends later in lower versus higher elevations. With climate change, this elevational gradient of vegetation phenology is likely to shift as well. However, both the patterns and the underlying driving forces for potential changes in this elevational gradient of vegetation phenology are still unclear. Here, we used 500‐m resolutioned normalized difference vegetation index (NDVI) data from Moderate Resolution Imaging Spectroradiometer (MODIS) for the period of 2001 to 2017 to investigate changes in the start of growing season (SOS) along the elevational gradient for six mountains in northern China dominated by broadleaf deciduous forests. We found that while SOS consistently advanced for most of the pixels, the elevational lapse rate of SOS (SE) showed various trends for different mountains. Specifically, SE showed a significant (p‐value < .05) decreasing trend for the two southernmost mountains, indicating an increasing elevational synchronization in SOS. However, such phenological synchronization was not found in other temperate mountains. As warming has caused relatively consistent increases in heat forcing across different elevations and among different mountains but has led to highly various changes in chilling hours between high and low elevations, we suggested that the distinctive pattern in elevational synchronicity of spring phenology between southern and northern mountains in temperate China was primarily due to their different recent changes in chilling hours. Our work provides a novel key hypothesis for explaining the divergent changes in elevational gradients of vegetation phenology that can be tested in other regions for mountain ecosystems.
HPLC‐QTOF/MS‐based metabolomics to explore the molecular mechanisms of Yiqi Fumai Lyophilized Injection in heart failure mice
Authors: Yuan Guang‐ying , Liu Ze‐liang , Lai Qiong , Fu Fei , Zhang Lu , Kou Jun‐ping , Yu Bo‐yang , Li Fang 
Published: May 2021

AbstractChronic heart failure is a common and fatal disease triggered by loss of normal cardiac function. Yiqi Fumai Lyophilized Injection is widely used in the treatment of cardiovascular diseases, especially chronic heart failure. In this study, a model of chronic heart failure in mice was established with permanent coronary artery ligation followed by Yiqi Fumai Lyophilized Injection intervention for 14 days. Then, the endogenous metabolites of mice plasma and urine samples were screened through nontargeted metabolomics techniques. The results indicated that Yiqi Fumai Lyophilized Injection treatment changed the metabolic pattern of chronic heart failure and regulated valine, leucine, and isoleucine biosynthesis, taurine and hypotaurine metabolism, histidine metabolism and arginine biosynthesis, etc. Finally, the cardioprotective mechanism of Yiqi Fumai Lyophilized Injection was further verified in the mouse model of chronic heart failure and angiotensin II‐induced cardiac fibroblasts based on metabolomics. The results showed that Yiqi Fumai Lyophilized Injection could inhibit myocardial fibrosis to improve chronic heart failure. This study firstly elucidated the metabolic network and pathways regulated by Yiqi Fumai Lyophilized Injection, which might facilitate the realization of the clinically accurate application of Yiqi Fumai Lyophilized Injection in the treatment of chronic heart failure.
CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR‐145/STMN1 axis
Authors: Wang Jin , Lin Yan , Jiang Dong‐Hui , Yang Xi , He Xiao‐Guang 
Published: May 2021

AbstractNasopharyngeal carcinoma (NPC) is the most common type of human malignant tumor in the head and neck, and tumor angiogenesis is essential for its development. Here, we showed that the circRNA ZNF609/microRNA (miR)‐145/Stathmin 1 (STMN1) axis regulated angiogenesis in NPC.Circ‐ZNF609, miR‐145, and STMN1 expression in NPC cells and NPC samples were examined using qRT‐PCR. The protein levels of STMN1, VEGFR1, and VEGFR2 were evaluated using western blotting. VEGF level was determined by ELISA. The proliferation of NPC cells and HUVECs was examined using a CCK‐8 assay. Transwell assays and wound‐healing assays were applied to assess the migration of NPC cells and HUVECs, respectively. Angiogenesis of HUVECs was evaluated by an angiogenesis assay. In addition, a dual‐luciferase reporter assay and RNA pull‐down assays were employed to verify the binding relationship between circ‐ZNF609 and miR‐145 as well as between miR‐145 and STMN1. Here, we showed that circ‐ZNF609 and STMN1 expression was increased, while miR‐145 expression was decreased in NPC cells and NPC samples. Circ‐ZNF609 may negatively regulate miR‐145 expression by acting as a ceRNA. Silencing circ‐ZNF609 suppressed cell proliferation, migration, and angiogenesis in NPC, while knockdown of miR‐145 reversed these effects. In addition, we found that STMN1 was the downstream target of miR‐145. MiR‐145 overexpression suppressed cell proliferation, migration, and angiogenesis in NPC, which was abolished by STMN1 overexpression. Our data suggested that circ‐ZNF609 promotes cell proliferation, migration, and angiogenesis in NPC by upregulating the expression of STMN1 by sponging miR‐145 in NPC.
Podocentric view of glomerular proteinuria: Focused on cytoskeletal changes and toward promising targeted therapies and challenges
Authors: Kuo Mei‐Chuan , Liang Peir‐In , Chang Jer‐Ming 
Published: May 2021

AbstractAmong renal cells, podocytes (glomerular epithelial cells) are the most critical to prevent plasma proteins from excessive loss by forming their sophisticated foot processes (FP) and slit diaphragms (SD). A general finding in the glomeruli of patients with nephrotic syndrome is the foot processes “effacement” resulted from dysregulated actin cytoskeleton reorganization. Ultrastructural analysis in patients with nephrotic syndrome has demonstrated that such changes tend to be dynamic and can sometimes be reversible. In a more molecular sense, injured podocytes can no longer maintain their tight regulation and “retract” their FP, but not “efface” them. Past studies have revealed multiple exquisite mechanisms and arrays of proteins participating in the regulation of cytoskeletal rearrangement, and these mechanisms serve as potential targets to treat. A major challenge to develop specific therapies is the targeted mechanism has to be crucial and specific enough for podocyte‐oriented kidney diseases, and it would be even better to manifest in most of the glomerulonephritis. Studies have shown many approaches targeting different mechanisms, but none of them has been proved to be effective in clinical medicine. Up to the present, Abatacept (Orencia) is the first (and the only) clinical targeted therapy demonstrating limited success. It inhibits the co‐stimulatory response of B7‐1 (CD80) induced in various types of glomerulonephritis. Future clinical studies have to be expanded to substantiate this highly specific targeted therapy because the Abatacept effect is not generally accepted even within the nephrology community. Nevertheless, there are ongoing searches for specific treatment targeting podocytes through various approaches.
Has IMRD become IMRDi in management journals? Implications as an independent structural component of research articles
Authors: S. Plakhotnik Maria 
Published: May 2021

AbstractThe purpose of this study was to understand the practice of separating implications into separate sections or sub‐sections in scholarly articles that report empirical research in social sciences. Using a stratified random sampling strategy, I selected 120 articles from 40 journals in the field of management available via the Social Sciences Citation Index. I analysed the articles using qualitative content analysis that was guided by two research questions: (1) do journal articles include implications as an independent component? and (2) What guidance do journal editors provide about the presentation of implications in article submissions? The results show that 72% of articles separated implications into a section or sub‐section whilst the remaining 28% integrated them into other main sections. Of the first group, three quarters of authors separated implications into sub‐sections of the Discussion section and one quarter presented them as independent main sections that followed the Discussion. Several patterns related to the range, length, order, and type of implications sections and sub‐sections emerged. The results also showed that only 4% of journals mention implications in their guidelines for authors. Journal editors could use the results of this study to discuss the importance of implications to the journal strategic development, articulate their position on the article structure, and audit their guidelines. Researchers might use the study results to improve their article structure and, hence, increase chances of receiving positive editorial decision.