bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Family Intervention on Physical Activity and Sedentary Behavior in Children Aged 2.5–12 Years: A Meta-Analysis
Authors: Huang Ting , Zhao Guanggao , Tan Haoyuan , Wu Hua , Fu Jinmei , Sun Shunli , Lv Wendi , He Zihao , Hu Qiming , Quan Minghui 
Published: August 2021

Introduction: To use a quantitative approach to examine the effects of family interventions on physical activity (PA) and sedentary behavior (SB) in children aged 2. 5–12 years.Methods: PubMed, OVID, Web of Science, and others were searched from their inception to May 2020. Intervention studies that examined the effects of family interventions on PA among children aged 2.5–12 years were included in this meta-analysis. Lastly, subgroup analyses were conducted to examine the potential modifying effects of family intervention's characteristics and study quality.Results: Eleven articles met the inclusion criteria for this review. Studies investigated a range of PA outcomes, including moderate-to-vigorous PA (MVPA), total PA (TPA), daily steps, and SB levels. Meta-analysis showed that family intervention had a significant effect on PA [standardized mean difference (SMD) = 0.10; 95% CI = 0.01–0.19], especially for daily steps [weight means difference (WMD) = 1,006; 95% CI = 209–1,803], but not for SB (WMD = −0.38; 95% CI = −7.21–6.46). Subgroup analyses indicated the improvements in PA occurred when children were 6–12 years old, intervention focused on PA only, intervention duration ≤ 10 weeks, and “low risk of bias” study performed.Conclusions: Family intervention may be a promising way to promote children's PA levels, especially for daily steps.Trial Registration: Meta-analysis protocol was registered on PROSPERO: CRD42020193667.
Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation
Authors: Zhang Yiwei , Qi Zhipeng , Wang Wenjie , Wang Lei , Cao Fuliang , Zhao Linguo , Fang Xianying 
Published: August 2021

It has been reported that Celtis sinensis Pers. is employed as a folk medicine for the treatment of inflammatory diseases. But the mechanism supporting its use as anti-inflammatory remains unclear. To investigate the anti-inflammatory of Celtis sinensis Pers. ICR mice were provided Celtis sinensis Pers. leaf extract (CLE) at 100, 200 mg/kg after ginkgolic acids (GA) sensitization. Our data showed that CLE and the main flavonoid isovitexin in CLE could ameliorate GA-induced contact dermatitis in mice. Ear swelling, inflammatory cell infiltration and splenomegaly were inhibited significantly by isovitexin, while the weight loss of mice in the isovitexin-treated group was much better than that in the dexamethasone-treated group (positive control drug). It has been reported in previous research that GA-induced inflammation is closely related to the T cell response. Therefore, T cells were the focus of the anti-inflammatory effect of isovitexin in this paper. The in vivo results showed that isovitexin (10, 20 mg/kg) inhibited the expression of proinflammatory cytokines (TNF-α, IFN-γ, IL-2 and IL-17A) in lymph nodes, inhibited the secretion of cytokines into the serum from mice with contact dermatitis and promoted the expression of apoptosis-related proteins. In vitro, isovitexin also induced apoptosis and inhibited proinflammatory cytokine expression in Con A-activated T cells. Further study showed that the MAPK and STAT signaling pathways and the phosphorylation of SHP2 were inhibited by isovitexin. Both molecular docking and biological experiments indicated that SHP2 may be an anti-inflammatory target of isovitexin in T cells. Taken together, isovitexin can serve as a potential natural agent for the treatment or prevention of GA-induced inflammatory problems.
Screening of Quality Markers During the Processing of Reynoutria multiflora Based on the UHPLC-Q-Exactive Plus Orbitrap MS/MS Metabolomic Method
Authors: Bai Junqi , Su He , Liang Youling , Shi Xuhua , Huang Juan , Xu Wen , Zhang Jing , Gong Lu , Huang Zhihai , Qiu Xiaohui 
Published: August 2021

The root of Reynoutria multiflora (Thunb.) Moldenke (syn: Polygonum multiflorum Thunb.) is a distinguished herb that has been popularly used in traditional Chinese medicine. The raw Reynoutria multiflora (RRM) should be processed by steaming before use, and the processing time is not specified in the processing specification. Our previous studies showed that the efficacy and toxicity of processed Reynoutria multiflora (PRM) at different processing times were inconsistent. A comprehensive identification method was established in this study to find a quality marker of raw Reynoutria multiflora (RRM) and processed Reynoutria multiflora (PRM) with different processing times. Metabolomics based on ultra-high-performance liquid chromatography tandem quadrupole/electrostatic field orbitrap high-resolution mass spectrometry (UHPLC-Q-Exactive plus orbitrap MS/MS) was used in this study. Using the CD.2 software processed database, multivariate statistical analysis methods coupled with cluster analysis and heatmap were implemented to distinguish between RRMs and PRMs with different processing times. The results showed that RRM and PRMs processed for 4, 8, 12, and 18 h cluster into group 1, and PRM processed for 24 and 32 h into group 2, indicating that it can effectively distinguish between the two groups and twenty potential markers, made the highest contributions to the observed chemical differences between two groups. Among them, tetrahydroxystilbene-O-hexoside-O-galloyl and sucrose can be used to identify PRM processed for 24 h. Therefore, the properties of RRM changed after 24 h of processing, and the quality markers were screened to distinguish RRM and PPM. It can also be used as an important control technology for the processing of RM, which has wide application prospects.
Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells
Authors: Gross Chase , Ramirez Dominique A. , McGrath Stephanie , Gustafson Daniel L. 
Published: August 2021

Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently used both as a nutraceutical and therapeutic. Despite anecdotal evidence as an anticancer agent, little is known about the effect CBD has on cancer cells. Given the intractability and poor prognoses of brain cancers in human and veterinary medicine, we sought to characterize thein vitrocytotoxicity of CBD on human and canine gliomas. Glioma cells treated with CBD showed a range of cytotoxicity from 4.9 to 8.2 μg/ml; canine cells appeared to be more sensitive than human. Treatment with &gt;5 μg/ml CBD invariably produced large cytosolic vesicles. The mode of cell death was then interrogated using pharmacologic inhibitors. Inhibition of apoptosis was sufficient to rescue CBD-mediated cytotoxicity. Inhibition of RIPK3, a classical necroptosis kinase, also rescued cells from death and prevented the formation of the large cytosolic vesicles. Next, cellular mitochondrial activity in the presence of CBD was assessed and within 2 hours of treatment CBD reduced oxygen consumption in a dose dependent manner with almost complete ablation of activity at 10 μg/ml CBD. Fluorescent imaging with a mitochondrial-specific dye revealed that the large cytosolic vesicles were, in fact, swollen mitochondria. Lastly, calcium channels were pharmacologically inhibited and the effect on cell death was determined. Inhibition of mitochondrial channel VDAC1, but not the TRPV1 channel, rescued cells from CBD-mediated cytotoxicity. These results demonstrate the cytotoxic nature of CBD in human and canine glioma cells and suggest a mechanism of action involving dysregulation of calcium homeostasis and mitochondrial activity.
Malignant Tumors Misdiagnosed as Liver Hemangiomas
Authors: Yıldırım Murat Baki , Şahiner İbrahim Tayfun , Poyanlı Arzu , Acunaş Bülent , Güllüoǧlu Mine , İbiş Cem , Tekant Yaman , Özden İlgin 
Published: August 2021

Background and Aim: To derive lessons from the data of patients who were followed for various periods with the misdiagnosis of liver hemangioma and eventually found to have a malignancy.Material and Methods: The records of 23 patients treated between 2003 and 2018 were analyzed retrospectively.Results: Twelve patients were men and 11 were women; median (range) age was 55 (35–80). The principal diagnostic modality for the initial diagnosis was ultrasonography (n:8), magnetic resonance imaging (MRI) (n:13), and computed tomography (CT) (n:2). At our institution, MRI was performed in 16 patients; the diagnosis was made with the available MRI and CT studies in five and two patients, respectively. In other words, the ultrasonography interpretations were not confirmed on MRI; in others, the MRI or CT examinations were of low quality or they had not been interpreted properly. Fifteen patients underwent surgery; the other patients received chemotherapy (n:6) or chemoembolization (n:2). The misdiagnosis caused a median (range) 10 (0–96) months delay in treatment. The final diagnoses were hepatocellular carcinoma in 12 patients, cholangiocarcinoma in four patients, metastatic mesenchymal tumor, metastasis of colon cancer, metastatic neuroendocrine carcinoma, sarcomatoid hepatocellular carcinoma, angiosarcoma, thoracic wall tumor, and metastatic tumor of unknown primary in one patient each.Conclusions: High-quality MRI with proper interpretation and judicious follow up are vital for the accurate differential diagnosis of liver lesions.
Health Profile of Precarious Migrants Attending the Médecins Du Monde’s Health and Social Care Centres in France: a Cross-Sectional Study
Authors: Halley Emeraude , Giai Joris , Chappuis Marielle , Tomasino Anne , Henaine Roland , Letrilliart Laurent 
Published: August 2021

Objective: The present study aimed to compare the precarious migrants’ health problems managed in Médecins du Monde’s health and social care centres (CASO) with those of patients attending general practice in France.Methods: We compared the most frequent health problems managed in the 19 CASO in metropolitan France with those of a national sample of usual general practice consultations, after standardisation for age and sex.Results: Precarious migrants had fewer health problems managed per consultation than other patients (mean: 1.31 vs. 2.16), and these corresponded less frequently to chronic conditions (21.3% vs. 46.8%). The overrepresented health problems among CASO consultations were mainly headache (1.11% vs. 0.45%), viral hepatitis (1.05% vs. 0.20%), type 1 diabetes (1.01% vs. 0.50%) and teeth/gum disease (1.01% vs. 0.23%). Their underrepresented health problems were mainly lipid disorder (0.39% vs. 8.20%), depressive disorder (1.36% vs. 5.28%) and hypothyroidism (0.50% vs. 3.08%). Prevention issues were nominal in precarious migrants (0.16%).Conclusion: Both chronic somatic and mental conditions of precarious migrants are presumably underdiagnosed. Their screening should be improved in primary care.
Anterior Fontanel Size Among Term Newborns: A Systematic Review and Meta-Analysis
Authors: Oumer Mohammed , Tazebew Ashenafi , Alemayehu Mekuriaw 
Published: August 2021

Background:Anterior fontanel is an integral element of an infant craniofacial system. There are six fontanels in the newborn skull, namely anterior, posterior, two mastoid, and two sphenoid fontanels. The anterior fontanel is the largest, prominent, and most important for clinical evaluation. Sex, race, genetics, gestational age, and region are the principal factors that influence anterior fontanel size. There exist inconclusive findings on the size of anterior fontanel in newborns. Therefore, this systematic review and meta-analysis aimed to determine the pooled mean size of anterior fontanel among term newborns and to identify the pooled mean difference of anterior fontanel size between males and females.Methods:PubMed/Medline, Google Scholar, Science Direct, JBI Library, embase, and Cochrane Library databases were systematically searched. All essential data were extracted using a standardized data extraction format. The heterogeneity across studies was assessed using the Cochrane Q test statistic, I2test statistic, andp-values. A fixed-effect model and random effect model were used to estimate the pooled mean size of anterior fontanel and the pooled mean difference between male newborns and female newborns, respectively. To deal with heterogeneity, sub-group analysis, meta-regression analysis, and sensitivity analysis were considered. JBI quality appraisal checklist was used to evaluate the quality of studies.Results:In this meta-analysis, 8, 661 newborns were involved in twenty-six studies. Among studies, 13 conducted in Asia, 7 in Africa, 5 in America, and 1 in Europe. The pooled mean size of anterior fontanel was 2.58 cm (95% CI: 2.31, 2.85 cm). The pooled mean size of anterior fontanel for Asia, Africa, America, and Europe region was 2.49, 3.15, 2.35, and 2.01 cm, respectively. A statistically significant mean difference was detected between male and female newborns (D + L pooled MD = 0.15 cm, 95% CI: 0.02, 0.29 cm).Conclusion:The pooled estimate of this review does provide the mean value of the anterior fontanel size in the newborns. There was a statistically significant mean fontanel size difference between male and female newborns. Therefore, male newborns had a significantly larger mean size than female newborns.
Neutron-Induced Nuclear Cross-Sections Study for Plasma Facing Materials via Machine Learning: Molybdenum Isotopes
Authors: Hamid Mohamad Amin Bin , Beh Hoe Guan , Oluwatobi Yusuff Afeez , Chew Xiao Yan , Ayub Saba 
Published: August 2021

In this work, we apply a machine learning algorithm to the regression analysis of the nuclear cross-section of neutron-induced nuclear reactions of molybdenum isotopes, 92Mo at incident neutron energy around 14 MeV. The machine learning algorithms used in this work are the Random Forest (RF), Gaussian Process Regression (GPR), and Support Vector Machine (SVM). The performance of each algorithm is determined and compared by evaluating the root mean square error (RMSE) and the correlation coefficient (R2). We demonstrate that machine learning can produce a better regression curve of the nuclear cross-section for the neutron-induced nuclear reaction of 92Mo isotopes compared to the simulation results using EMPIRE 3.2 and TALYS 1.9 from the previous literature. From our study, GPR is found to be better compared to RF and SVM algorithms, with R2=1 and RMSE =0.33557. We also employed the crude estimation of property (CEP) as inputs, which consist of simulation nuclear cross-section from TALYS 1.9 and EMPIRE 3.2 nuclear code alongside the experimental data obtained from EXFOR (1 April 2021). Although the Experimental only (EXP) dataset generates a more accurate cross-section, the use of CEP-only data is found to generate an accurate enough regression curve which indicates a potential use in training machine learning models for the nuclear reaction that is unavailable in EXFOR.
Effect of α-Terpineol on Chicken Meat Quality during Refrigerated Conditions
Authors: Hussein Khabat Noori , Csehi Barbara , József Surányi , Ferenc Horváth , Kiskó Gabriella , Dalmadi István , Friedrich László 
Published: August 2021

The present study was designed to evaluate the in vitro antimicrobial properties of nine bioactive compounds (BACs). Applying the disc paper and minimum inhibitory concentration (MIC) assays, we found that the BACs with the widest spectrum of in vitro antibacterial activity against the studied bacteria were carvacrol and α-terpineol (αTPN). Subsequently, αTPN was selected and applied at different concentrations into the fresh minced chicken meat. The meat was then vacuum packaged and stored for 14 days at 4 °C. Physicochemical properties, lipid oxidation (thiobarbituric acid reactive substances, TBARS), electronic-nose-based smell detection, and microbiological characteristics were monitored. At day 14, meat treated with higher concentrations of αTPN (MIC-2 and MIC-4) exhibited a significantly increased pH and lightness (L*), increased yellowness (b*), decreased redness (a*), caused a significant decrease in water holding capacity (WHC), and decreased lipid oxidation by keeping TBARS scores lower than the control. Although αTPN showed perceptibly of overlapped aroma profiles, the E-nose was able to distinguish the odor accumulation of αTPN between the different meat groups. During the 2-week storage period, αTPN, particularly MIC-4, showed 5.3 log CFU/g reduction in aerobic mesophilic counts, causing total inhibition to the Pseudomonas lundessis, Listeria monocytogenes, and Salmonella Typhimurium. These promising results highlight that αTPN is exploitable to improve the shelf life and enhance the safety of meat and meat products.
Sebaceoma y Síndrome de Muir Torre
Authors: Orantes Ana , Gramajo Marisol 
Published: August 2021

El sebaceoma es una neoplasia benigna, papulonodular, amarillenta, que suele aparecer en rostro, piel cabelluda o en áreas con abundantes glándulas sebáceas. Se ha descrito en la literatura la asociación de neoplasias sebáceas con el síndrome de Muir Torre. Se presenta el caso de un paciente masculino con antecedente de cáncer de colon y presencia de lesión cutánea única en tórax, dos años después del primer diagnóstico.
Maternal and fetal factors contributing to neonatal outcome in Al-Tibri Medical College and Hospital
Authors: Saboohi Erum , Seema Nighat , Hassan Abdulah Hadi 
Published: August 2021

Background: The study was done to identify the maternal and fetal factors contributing to neonatal outcome and to evaluate the correlation between risk factors and adverse neonatal outcome.
Subjects and methods: This prospective observational study was conducted on 126 mothers and their neonates fulfilling the selection criteria at Al-Tibri Medical College and Hospital. A self-designed Performa was used to enter data of subjects. Sick neonates were referred to neonatal intensive care unit for admission and management. The results were analyzed by using SPSS version 22. A p-values <0.05 was considered as significant.
Results: Out of 126 enrolled subjects, 81% mothers were multigravidas, 31% were unbooked, 13.5% had gestational comorbidities, 15% were drug addict, 2% were Hepatitis B positive. 22.2% underwent emergency LSCS while 31.7% delivered babies by elective LSCS. Regarding fetal factors contributing to sick babies, IUGR (20%), twin fetuses (15.4%), prematurity (47.7%) were significant. 65 were sick babies. Adverse neonatal outcomes observed were prematurity in 25.4%, IUGR in 11.1%, NICU admission in 33.3%, and neonatal death in 2%. Risk factors associated with adverse neonatal outcomes were positive maternal drug addiction (p-value = 0.028), preterm delivery (p-value<0.001), NICU admission (p-value<0.001) and low birth weight (p-value <0.001).
Conclusion: Compromised maternal antenatal care has profound deleterious effect on fetus and neonate. Obstetricians, perinatologists and neonatologists need to work in concord to improve maternal antenatal care hence improving neonatal outcome. In our study adverse neonatal outcome was associated with unbooked cases, delivery by EmLSCS, addicted mother, preterm delivery, LBW and neonates requiring NICU admission.
Prevalence of insomnia and anxiety in university students during the COVID-19 lockdown: A cross-sectional study
Authors: Mahmood-ul-Hassan Ameer Hamza , Sannan Abdul , Nooz Nehala , Ramay Ansa , Huzaifa Muhammad , Zaidi Syed Muhammad Jawad , Mahmood-ul-Hassan Ayesha 
Published: August 2021

Background: The world is facing COVID-19 pandemic and almost 70% of the world had gone under Lockdown. People are facing stress, insomnia and anxiety. The lack of basic awareness and spread of fake news are common causes of all these issues. This study was done to determine the prevalence of insomnia and anxiety in medical and non-medical students.
Subjects and methods: Subjects were approached through friends in universities using WhatsApp. People having insomnia and anxiety before quarantine were excluded from this study. People using anti-depressants and anti-psychotics before quarantine were also excluded from this study. A descriptive cross-sectional study was conducted among 965 students of medical and non-medical universities in the cities of Lahore, Rawalpindi and Islamabad. Consent was taken for using the Hamilton Anxiety Rating Scale and Insomnia Severity Index for scoring of anxiety and insomnia respectively. An online questionnaire made in Google forms was used for data collection. Independent t-tests, Pearson Correlation and Regression analysis were performed using SPSS v25.
Results: Increased prevalence of anxiety and insomnia in non-medical students as compared to the medical students was observed. There was statistically significant strong correlation between anxiety and insomnia of the enrolled subjects (r=0.742, p<0.001). A linear regression equation was formulated. Increased prevalence of anxiety and insomnia in females was also determined.
Conclusion: Non-medical students, compared to medical students, among which, females, compared to males, were more likely to suffer from anxiety and insomnia during lockdown.
ВСЕУКРАЇНСЬКИЙ ВЕБІНАР З НАЦІОНАЛЬНО-ПАТРІОТИЧНОГО ВИХОВАННЯ «УКРАЇНА — МОЯ БАТЬКІВЩИНА»
Authors: Рейпольська Ольга Дмитрівна , Малиношевський Руслан Васильович 
Published: August 2021

Представлено результати роботи Всеукраїнського вебінару з національно-патріотичного виховання «Україна — моя Батьківщина», який організовано з нагоди 30-річчя Незалежності України і проведено 22 червня 2021 р. Мета вебінару полягала в обговоренні актуальних проблем розроблення та впровадження технологій національно-патріотичного виховання дітей дошкільного віку в освітньому процесі закладів дошкільної освіти України, презентування новітніх практик та найкращого досвіду щодо виховання національної ідентичності дітей дошкільного віку в умовах закладів дошкільної освіти. Організаторами вебінару виступили Міністерство освіти і науки України, Національна академія педагогічних наук України (Відділення загальної педагогіки та філософії), Інститут проблем виховання Національної академії педагогічних наук України, Державна установа «Український інститут розвитку освіти».
An innovative model to quantify corneal transparency in donor corneal buttons
Authors: Rose Jeyanth , Wankhar Syrpailyne , Joshua Aarwin , Korah Sanita , Kuriakose Thomas 
Published: August 2021

Assessment of corneal transparency in donor corneal buttons has only been performed qualitatively. The quantification of corneal transparency has implications with respect to clinical suitability of the donor cornea and research involving corneal transparency as an outcome measure. In this study an artificial anterior chamber was modified to create a central transparent passage. This was made possible by replacing the base of the chamber with Perspex and a water tight seal. An inlet and outlet tube was a ached to the sides of chamber. This was done to maintain a standardized pressure within the chamber when connected to an IV bo le. A corneal button rejected for corneal transplant was placed on the artificial anterior chamber and the chamber was filled with normal saline. A digital camera and a laser source were placed on either side of the chamber at predetermined intervals. Alignment was achieved so that the laser light passed through the center of the cornea. The image of the laser spot was acquired and subjected to image analysis. To test this proof of concept, a human cornea rejected for human transplant was injected with intrastromal saline to create corneal haze. Pre and Post injection images were analyzed. The average pixel intensity that was calculated was found to be 111 pre-saline injury and 17.2 post-saline injection. Pre and Post-saline measurement showed a marked difference in average pixel intensity. This simple inexpensive setup and ease of analysis are advantages of this method of quantification.