bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia
Authors: Sun Fei , Wang Guolun , Pradhan Arun , Xu Kui , Gomez-Arroyo Jose , Zhang Yufang , Kalin Gregory T. , Deng Zicheng , Vagnozzi Ronald J. , He Hua , Dunn Andrew W. , Wang Yuhua , York Allen J. , Hegde Rashmi S. , Woods Jason C. , Kalin Tanya V. , Molkentin Jeffery D. , Kalinichenko Vladimir V. 
Published: June 2021

Background:

Pulmonary hypertension (PH) is a common complication in patients with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with mutations in the
FOXF1
gene. Although the loss of alveolar microvasculature causes PH in patients with ACDMPV, it is unknown whether increasing neonatal lung angiogenesis could prevent PH and right ventricular (RV) hypertrophy.

Methods:

We used echocardiography, RV catheterization, immunostaining, and biochemical methods to examine lung and heart remodeling and RV output in
Foxf1

WT/S52F

mice carrying the
S52F Foxf1
mutation (identified in patients with ACDMPV). The ability of
Foxf1

WT/S52F

mutant embryonic stem cells to differentiate into respiratory cell lineages in vivo was examined using blastocyst complementation. Intravascular delivery of nanoparticles with a nonintegrating
Stat3
expression vector was used to improve neonatal pulmonary angiogenesis in
Foxf1

WT/S52F

mice and determine its effects on PH and RV hypertrophy.

Results:

Foxf1

WT/S52F

mice developed PH and RV hypertrophy after birth. The severity of PH in
Foxf1

WT/S52F

mice directly correlated with mortality, low body weight, pulmonary artery muscularization, and increased collagen deposition in the lung tissue. Increased fibrotic remodeling was found in human ACDMPV lungs. Mouse embryonic stem cells carrying the
S52F Foxf1
mutation were used to produce chimeras through blastocyst complementation and to demonstrate that
Foxf1

WT/S52F

embryonic stem cells have a propensity to differentiate into pulmonary myofibroblasts. Intravascular delivery of nanoparticles carrying
Stat3
cDNA protected
Foxf1

WT/S52F

mice from RV hypertrophy and PH, improved survival, and decreased fibrotic lung remodeling.

Conclusions:
Nanoparticle therapies increasing neonatal pulmonary angiogenesis may be considered to prevent PH in ACDMPV.
Lack of Reperfusion Rather Than Number of Passes Defines Futility in Stroke Thrombectomy: A Matched Case-Control Study
Authors: Mohammaden Mahmoud H. , Haussen Diogo C. , Pisani Leonardo , Al-Bayati Alhamza R. , Bianchi Nicolas , Liberato Bernardo , Bhatt Nirav , Jillella Dinesh , Frankel Michael R. , Nogueira Raul G. 
Published: June 2021

Background and Purpose:
There is a robust relationship between the duration of ischemia and functional outcomes after mechanical thrombectomy. Higher number of mechanical thrombectomy passes strongly correlate with lower chances of favorable outcomes. Indeed, previous studies have suggested that after multiple passes the procedure may be futile. However, using uncontrolled thresholds to define thrombectomy futility might be misleading. We aim to compare the outcome of successful reperfusion after 4 to 5 passes and ≥6 passes with those of failed reperfusion.

Methods:
A prospectively acquired mechanical thrombectomy database from January 2012 to October 2019 was reviewed. Patients were included if they had intracranial internal carotid artery or middle cerebral artery-M1/M2 occlusions and either achieved successful reperfusion after ≥4 passes or failed reperfusion. Reperfused patients (mTICI2b-3) were divided into 2 subgroups; (1) 4 to 5 passes and (2) ≥6 passes. Each subgroup was compared with a matched group of mechanical thrombectomy failure (mTICI0-2a). The primary outcome was the shift in the degree of disability at 90-day as measured by the modified Rankin Scale.

Results:

A total of 273 patients were included. As compared with matched failed reperfusion patients (n=62), those reperfused after 4 to 5 passes (n=62) had a favorable shift in the overall modified Rankin Scale score distribution (adjusted odds ratio, 3.992 [95% CI, 1.807–8.512],
P
=0.001] and higher rates of functional independence (31% versus 8.9%,
P
=0.004, adjusted odds ratio; 9.860 [95% CI, 2.323–41.845],
P
=0.002) at 90 days. Similarly, when compared with a matched group of failed reperfusion (n=42), patients reperfused after ≥6 passes (n=42) demonstrated a favorable shift in the overall modified Rankin Scale score distribution (adjusted odds ratio, 2.640 [95% CI, 1.073–6.686],
P
=0.037) and had higher rates of functional independence (36.8% vs 11.1%,
P
=0.004, adjusted odds ratio, 5.392 [95% CI, 1.185–24.530],
P
=0.029) at 90 day. Rates of parenchymal hematoma type-2 and 90-day mortality were comparable in the reperfused and nonreperfused groups.

Conclusions:
Achieving reperfusion despite multiple passes leads to improved outcomes compared with failed procedures. Arbitrary uncontrolled thresholds for a maximum number of passes to predict futile recanalization may lead to inappropriate early termination of procedures.
Implementation Studies in Mathematics Education: What Theoretical Resources?
Authors: Artigue Michèle 
Published: June 2021

Abstract
This article is devoted to the theoretical resources likely to support implementation studies. After the introductory section, we focus on the potential offered by resources internal to the field of mathematics education, especially those offered by design-based research, by the systemic and ecological perspective underlying the anthropological theory of the didactic, and by the documentational approach to didactics regarding the teachers’ relationship with educational resources. We then examine particular examples of implementation studies, paying specific attention to the way they combine internal and external resources. For that purpose we consider on the one hand, European projects aiming at the large-scale implementation of inquiry-based learning and teaching in STEM education, especially the PRIMAS project, and on the other hand, the contributions to the thematic working group devoted to implementation and replication studies at CERME 10 and CERME 11. We conclude with more general reflections.
ENTRAINMENT IN A SIMULATED SUPERCELL THUNDERSTORM, PART I: THE EVOLUTION OF DIFFERENT ENTRAINMENT MECHANISMS AND THEIR DILUTIVE EFFECTS
Authors: Lasher-Trapp Sonia , Jo Enoch , Allen Luke R. , Engelsen Bryan N. , Trapp Robert J. 
Published: June 2021

AbstractThe current study identifies and quantifies various mechanisms of entrainment, and their diluting effects, in the developing and mature stages of a simulated supercell thunderstorm. The two stages, differentiated by the lack or presence of a rotating updraft, are shown to entrain air by different, but related mechanisms that result from the strong vertical wind shear of the environment. The greatest entrainment rates in the developing stage result from the asymmetric overturning of large eddies near cloud top on the down-shear side. These rates are greater than those published in the literature for cumuli developing in environments lacking strong shear. Although the entrainment rate increases exponentially in time throughout the developing stage, successive cloud turrets help to replenish some of the lost buoyancy and condensate, allowing the nascent storm to develop further. During the mature stage, the greatest entrainment rates occur via “ribbons” of horizontal vorticity wrapping around the rotating updraft that ascend in time. The smaller width of the ribbons in comparison to the wider storm core limits their dilutive effects. Passive tracers placed in the low-level air ingested by the mature storm indicate that on average 20% of the core contains some undiluted air ingested from below the storm base, unaffected by any entrainment mechanism.
Finding Feminism through Faith: Casa Yela, Popular Feminism, and the Women-Church Movement in Chile
Authors: Hiner Hillary 
Published: June 2021

Among the popular feminist projects of the dictatorship period in Chile was the Yela group in Talca, made up of pobladoras (women shantytown residents) and two Maryknoll sisters. Of particular interest is the manner in which this group’s popular feminism and antiviolence work during the 1980s was shaped by the women-church movement and feminist theology related to patriarchy, violence against women, and women’s collective resistance strategies. Over the long term, religious elements were gradually excluded from Casa Yela’s antiviolence work in favor of more secular feminist interpretations. Entre los proyectos feministas populares durante la época de la dictadura en Chile se encuentra la presencia del grupo Yela de Talca, formado por pobladoras (mujeres residentes de poblaciones) y dos hermanas Maryknoll. De particular interés es la forma en que el feminismo popular y antiviolencia de este grupo durante la década de 1980 se moldeó a partir del movimiento mujer-iglesia y la teología feminista relacionada con el patriarcado, la violencia contra las mujeres y las estrategias de resistencia colectiva de mujeres. A largo plazo, los elementos religiosos fueron gradualmente excluidos del trabajo antiviolencia de Casa Yela en favor de interpretaciones feministas más seculares.
The World March of Women: Popular Feminisms, Transnational Struggles
Authors: Díaz Alba Carmen Leticia 
Published: June 2021

The World March of Women is an example of the transnationalization of popular feminism from below as defined by four elements: the diversity of women’s struggles, grassroots women as political subjects, alliances with mixed movements, and popular education as a feminist methodology. Class analysis is most prominent, with tensions and challenges linked to attempts to address issues of heteronormativity and racial colonialism, in part because of differences between local spaces in a global network and between relatively more localized and transnationalized scales of practice. A Marcha Mundial das Mulheres é um exemplo de transnacionalização do feminismo popular desde abaixo definido por quatro elementos: diversidades nos obstáculos das mulheres, as mulheres de raiz como sujeitos políticos, alianças com movimentos mistos e educação popular como metodologia feminista. A análise de classe é mais proeminente, com tensões e desafios ligados às tentativas que abordam questões de heteronormatividade e colonialismo racial, em parte por causa das diferenças entre espaços locais dentro de uma rede global e entre escalas de prática relativamente locais e transnacionalizadas.
The effect of opening windows on the airflow distribution inside naturally ventilated residential bedrooms with ceiling fans
Authors: Jayasree Thaliyara Kesavan , Jinshah Basheer Sheeba , Srinivas Tadepalli 
Published: June 2021

Ceiling fans are the most common equipment in any household with electricity to induce a higher air movement since the potential of natural ventilation is limited. However, the higher airflow region is generally limited to the zone below the fan. The non-uniform distribution of airflow is also affected by the furniture layout and airflow from window openings. This study attempts to evaluate the effect of the different window-opening patterns on the airflow inside naturally ventilated bedrooms, having a ceiling fan for air movement with numerical simulations and on-site measurements. The airflow pattern created by a ceiling fan in a room with furniture is modelled and simulated with ANSYS Fluent 2019 R3. The results were validated with on-site measurements and compared with the literature. The air velocity was measured in bedrooms of three different sizes. It was observed that the opening of windows created a better distribution of air irrespective of room size. The non-uniformity of the air velocity is reduced from 76% to 39% with the opening of windows in the larger-sized room. The reduction in non-uniformity is influenced by the location of windows also. The practice of opening windows along with the induced air movement by ceiling fans results in a better distribution of air in the space. Practical application: People tend to depend mainly on ceiling fans even if windows are open in naturally ventilated rooms. A study of patterns of non-uniform distribution of airflow can help designers to improve comfort conditions by specifying the number and location of fans and windows while designing room furniture layout. This aids the building services engineers to provide thermal comfort without always depending on alternative active ventilation strategies.
Management Strategy of Local Subcutaneous Effusion After Auricle Reconstruction
Authors: Guo Rui , Liu Tun , Wang Bingqing , Zhang Qingguo 
Published: June 2021

Objectives: Microtia is a severe congenital malformation of the external ear, and auricular reconstruction is still a challenge for plastic surgeons because of the complicated procedures and rare conditions. This study aimed to describe the location of subcutaneous effusion after auricular reconstruction and explore the clinical efficacy of the indwelling needle puncture drainage method in the treatment of local subcutaneous effusion. Methods: From January 2017 to December 2019, 1240 patients (1296 affected sides) who underwent auricular reconstruction using autogenous cartilage framework in the Plastic Surgery Hospital of Chinese Academy of Medical Science and Peking Union Medical College were selected. The local subcutaneous effusion occurred within 5 days after the drainage tube was removed, and the indwelling needle was used for puncture and drainage in the postoperative treatment. Results: A total of 55 patients had subcutaneous effusion after the operation, including 24 cases with Nagata’s method and 31 cases with the expanded single-flap method. One patient showed no obvious reduction after puncture and drainage by indwelling needle and improved after the secondary operation. Two patients had slight cartilage absorption. The remaining patients had good results. Conclusions: The method of the indwelling needle for puncture and drainage is easy to operate. The problem of local subcutaneous effusion after auricular reconstruction can be solved and good efficacy can be obtained.
Sleep disturbance: The overlooked side after open heart surgery in adults
Authors: Bakry Ahmed MA , Abdelmohty Hysam , Badawy Ahmed E , Shorbagy Mohammed S , Eldib Osama S 
Published: June 2021

Background Sleep is essential for full mental and physical renewal. Cardiac surgery improves the life expectancy and quality. But unfortunately, some patients lacked that merit as they suffered sleep disturbance. We used validated questionnaire applied to 153 cardiac surgery patients to assess the sleep disturbances after surgery. Results About 70 (45.8%) had valve procedure, 55 (36%) had revascularization, 19 (12.4%) had both procedures and 9 (5.8%) had other procedures. The majority had no post-operative bleeding nor infection. About 78% had sleeping difficulty for one month. About 50% used different medications to fall asleep, mostly analgesics. About 76% slept after 2–6 h irrespective of sleep quality. Some patients had poor sleep quality in the form of nightmares and night terrors. Conclusion Sleep quality was disturbed immediately following cardiac surgery. There was a reduction of night sleep compensated by increased daytime sleepiness. These changes almost reverted one month after surgery.
Clinical features, treatment and outcome of discospondylitis in cats
Authors: Gomes Sergio A , Garosi Laurent S , Behr Sebastien , Toni Cristina , Tabanez Joana , Rusbridge Clare , Targett Mike , Lowrie Mark 
Published: June 2021

Objectives There is a paucity of information on feline discospondylitis. This study aimed to describe the signalment, clinical and laboratory findings, aetiological agents, treatment and outcome in cats affected by discospondylitis. Methods This was a retrospective review of the medical records of cats diagnosed with discospondylitis at four referral institutions. Results A total of 17 cats were identified. Most were domestic shorthair cats (76.5%) and male (58.8%), with a median age of 9 years (range 0.9–14) and a median duration of clinical signs of 3 weeks (range 0.3–16). All cats presented with spinal hyperaesthesia; 3/17 had pyrexia. Neurological dysfunction was found in 64.7% of cats, which was indicative of a T3–L3 or L4–S2 spinal segment, associated nerve root or associated nerve neurolocalisation. Haematology, serum biochemistry and urinalysis revealed occasional inconsistent non-specific changes. All cats underwent urine culture; 9/17 cats also had a distinct tissue cultured. Positive bacterial cultures were obtained in two cats (11.8%) for Staphylococcus species (urine, blood and intradiscal fine-needle aspirate) and Escherichia coli (urine); both presented with multifocal discospondylitis. Treatment was non-surgical in all cats, with sustained antibiotic therapy for a median of 3 months (range 1–9). Analgesia provided included non-steroidal anti-inflammatory drugs, alone or in combination with gabapentin. Restricted exercise was advised for a minimum of 4 weeks. Outcome information available in 12 cats was excellent in terms of pain control and neurological function in 10 cats (83.3%) at the time of stopping antibiotics. Recurrence occurred in one case, which had received a single antibiotic for 6 weeks, and relapsed 4 months after presentation. One other case failed to improve and was euthanased during the course of hospitalisation. Conclusions and relevance Feline discospondylitis is uncommon and no obvious signalment predisposition was found in this study. Spinal hyperaesthesia was universally present, with neurological dysfunction also highly prevalent. Bacterial culture was unrewarding in most cases. Amoxicillin–clavulanic acid or cephalosporins are reasonable choices for first-line antibiotics. Prognosis was favourable, with no long-term evidence of recurrence in cats on sustained antibiotic therapy, for a mean duration of 3 months.
Lacrimal Function and Ocular Complications in Patients Treated with Systemic Isotretinoin
Authors: Bozkurt B. , ÍRkeç M.T. , Atakan N. , Orhan M. , Geyik P.Ö. 
Published: June 2021

Purpose To evaluate the effect on lacrimal function and ocular complications in patients with severe acne vulgaris during systemic treatment with 13- cis -retinoic acid (isotretinoin). Methods Forty patients with acne vulgaris were treated with systemic isotretinoin at dosages of 0.5-1 mg/kg per day for two months. Full ophthalmologic examination, Schirmer / test, fluorescein break-up (BUT) and microbiological investigations of the conjunctival flora were done before, during the second month and at least one month after the end of the treatment. Results The average Schirmer values before and after the treatment were 21.6 mm/5 minutes (SD ± 7.01) and 18.48 mm/5 minutes (SD ± 7.87) respectively. After the treatment BUT was less than 10 seconds in 50% of the patients and 55% had blepharitis. Subjective symptoms like dryness, itching and contact lens intolerance occurred in 42.5% and colonization of the conjunctiva by Staphylococcus aureus increased significantly during treatment (p = 0.031). All abnormal findings disappeared one month after the cessation of treatment. Discussion Isotretinoin causes signs and symptoms of dry eye, probably by reducing meibomian gland function, but ocular complications are generally not serious when low doses are used for a limited time, and are reversible after discontinuation.
No difference in whole-blood metal ions between 32-mm and 36- to 44-mm femoral heads in metal-on-polyethylene total hip arthroplasty: a 2-year report from a randomised control trial
Authors: Bunyoz Kristine I , Tsikandylakis Georgios , Mortensen Kristian , Gromov Kirill , Mohaddes Maziar , Malchau Henrik , Troelsen Anders 
Published: June 2021

Aim: To investigate the effect of femoral head size on blood metal-ion levels caused by taper corrosion in metal-on-polyethylene total hip arthroplasty, comparing 36- to 44-mm heads with 32-mm heads. Methods: In a randomised, controlled, single-blinded trial, 96 patients were allocated to receive either a 32-mm metal head or the largest possible metal head (36–44 mm) that could be accommodated in the thinnest available vitamin E, cross-linked polyethylene insert. Blood metal ion levels were collected at 1- and 2-year follow-ups. Results: At 1-year, metal-ion levels did not differ between the groups. The median (interquartile range) blood-ion levels for the 32-mm versus the 36- to 44-mm group were 0.11 µg/L (0.08–0.15) versus 0.12 µg/L (0.08–0.22), p = 0.546, for cobalt, 0.50 µg/L (0.50–0.59) versus 0.50 µg/L (0.50–1.20), p = 0.059, for chromium and 1.58 µg/L (1.38–2.05) versus 1.48 µg/L (1.14–1.87), p = 0.385, for titanium. At 2 years, there was no difference either and the corresponding values were 0.15 µg/L (0.12–0.24) versus 0.18 µg/L (0.12–0.28), p = 0.682 for cobalt, 0.50 µg/L (0.50–0.50) versus 0.50 µg/L (0.50–0.57), p = 0.554, for chromium and 1.54 µg/L (1.16–1.87) versus 1.42 µg/L (1.01–1.72), p = 0.207 for titanium. Conclusions: The use of the largest possible metal head (36–44 mm) compared to a 32-mm head in metal–on-polyethylene bearings does not appear to elevate blood metal-ion levels up to 2 years postoperatively. As taper corrosion is probably time-dependent, longer-term reports are needed to evaluate the association between large metal heads and blood metal ion levels. Trial registration: ClinicalTrials.gov (reg. ID NCT0231 6704)
Researching language and cognition in bilinguals
Authors: Bassetti Bene , Filipović Luna 
Published: June 2021

Aims: This article reviews recent research on the relationship between language and thinking in bilinguals. Approach: The paper reviews aspects of previous research, and links it to the articles in this special issue. Conclusions: Research on language and cognition in bilinguals requires both depth (in-depth investigations of one area in order to test approaches and methods) and breadth (investigations of a wide range of research areas). It should cover all levels of language and all aspects of cognition, in line with the latest theoretical and methodological developments in relevant disciplines (e.g. using linguistic and non-linguistic tasks, collecting quantitative and qualitative data). Originality and significance: This introduction discusses important theoretical and methodological aspects of recent developments in the field.