bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Metode Pembelajaran Berbasis Masalah Pada Pembelajaran Tema 2 “Selalu Berhemat Energi” Kelas IV Peserta Didik MIN 2 Kediri
Authors: Diba Farah 
Published: February 2021

The background of this research is: to attract students in theme learning, there needs to be a fun learning method. Therefore, problem based learning methods is selected. Researchers chose the PBL because this approach uses a learning step by steps that define problems, diagnose problems, formulate alternative strategies, define and implement preferred strategies and evaluations. The focus of this research is: (1) Implementation of problem-based Learning method (problem-Based learn) in theme 2 Always save energy learners class IV D MIN 2 Kediri (2) supporting factors in implementing learning methods Problem-based Learning Methods (IVD MIN 2 Kediri Class). While the purpose of this research is: (1) to describe the implementation of problem-based learning method in theme 2 "Always save energy. 2 To describe supporting factors in implementing a problem-based learning method. The research uses a qualitative approach using class action research (PTK). A qualitative approach is chosen, because with this research, it is hoped that we can collect the data obtained, then process, analyses and symbolize it, so that there is a clear understanding of the effectiveness of the method Problem-based learning in theme learning. Data collection is done by conducting observations, interviews, and documentation. Then data in analysis using data analysis is data reduction, data presentation and conclusion results. The results of the study are: (1) there is a success indicator of the successful learning percentage of the pre-action which is only 65.71% with an average value of 71.8. (2) On the complete learning to be 71.42 with a flat average of 74.9, so there is an increase of 5.71% (3) in the cycle II the satisfaction of learning reaches 88.57% with the average value of class 80.7 and there is an increase of cycle I and cycle II as much as 17.15. (4) With this can be seen the increase of the membership of the class as much as 22.86% from the activities of pre-action until cycle II already met the success indicator is amounting to more than 75% of the number of learners.
Kepemimpinan Kepala Sekolah Perempuan Lembaga Pendidikan Islam Dasar Di Kecamatan Nglegok Kabupaten Blitar
Authors: Badrus  , Wahyuni Lilik Sri 
Published: February 2021

This study aims to: (1) describe the Leadership of Women's School Principals in Nglegok, Blitar Regency; (2) describing the factors that support and hinder the leadership of women school principals in Nglegok, Blitar Regency. This research is a qualitative research. The research sites are Islamic Elementary Echool “Kreatif Zaid Bin Tsabit”, Primary School Ngoran 02, and Integrated Islamic Elementary School Wildan Mukholladun Nglegok Blitar. Resource persons for the study are principals, teachers, and operators. Data collection uses participant observation, interviews, and documentation. Data validity uses triangulation with data sources. Data analysis techniques by data reduction, data presentation, data analysis, drawing conclusions, and verification. The results showed: (1) Leadership of female school principals in Nglegok Sub-District, Blitar Regency had been going well, it was proven that the school principal had carried out several strategic policies. (2) Factors that support the leadership of female school principals in Nglegok District, Blitar Regency include government policies, technological advances, increased awareness of the potential and existence of women, state recognition of women's potential, human rights enforcement and a democratic system. While the inhibiting factors are rigidity in interpreting the text of religion, feelings of doubt and lack of confidence in some women.
Impaired Left Atrial Performance Resulting From Age-Related Arial Fibrillation Is Associated With Increased Fibrosis Burden: Insights From a Clinical Study Combining With an in vivo Experiment
Authors: Lin Kai-bin , Chen Kan-kai , Li Shuai , Cai Ming-qi , Yuan Min-jie , Wang Yan-peng , Zhang Xue , Wei Meng , Yan Mei-Ling , Ma Xin-Xin , Zheng Dong-Yan , Wu Qi-han , Li Jing-bo , Huang Dong 
Published: February 2021

Background: Atrial fibrillation (AF) is increasingly considered an age-related degenerative disease, whose process is associated with the development of impaired left atrial (LA) performance. However, the subtle dynamic changes of LA performance in AF during aging have yet to be fully elucidated. Atrial fibrosis is a key substrate for the development of AF, but the progression of fibrosis during aging and its relationship with LA dysfunction need to be further explored.Methods: A total of 132 control individuals and 117 persistent AF patients were prospectively studied. Subjects were further stratified into three age groups (age group 1: younger than 65 years, age group 2: between 65 and 79 years old, and age group 3: older than 80 years). The two-dimensional speckle tracking imaging was carried out for analyzing the alterations in LA function underlying LA remodeling, whereas electroanatomic mapping was performed to investigate LA fibrosis burden. In animal study, aged mice and young mice served as research subjects. Echocardiography and histological staining were used to assess LA performance and fibrosis burden, respectively.Results: Echocardiography showed progressive increases in LA dimension and LA stiffness index, and progressive decreases in LA global longitudinal strain and LA strain rates with advancing age in both AF and control cohorts, which was more prominent in AF cohort. Electroanatomic mapping showed progressive decrease in mean LA voltage and progressive increases in LA surface area, low-voltage area %, and LA volume with advancing age, whereas more significant alterations were observed in AF patients. Moreover, left atrial global longitudinal strain was positively correlated with mean LA voltage, whereas LA stiffness index was negatively related to mean LA voltage. In animal experiment, increased LA size and pulmonary artery dimension as well as longer P-wave duration and more prominent LA fibrosis were found in aged mice.Conclusions: This study provides new evidence of subtle changes in structure and performance of left atrium and their association with atrial fibrosis in both AF and non-AF subjects during physiological aging. In addition, our study also provides normal values for LA structure and performance in both AF and non-AF conditions during aging. These measurements may provide an early marker for onset of AF and LA adverse remodeling.
Social Network Structure Is Related to Functional Improvement From Home-Based Telerehabilitation After Stroke
Authors: Podury Archana , Raefsky Sophia M. , Dodakian Lucy , McCafferty Liam , Le Vu , McKenzie Alison , See Jill , Zhou Robert J. , Nguyen Thalia , Vanderschelden Benjamin , Wong Gene , Nazarzai Laila , Heckhausen Jutta , Cramer Steven C. , Dhand Amar 
Published: February 2021

Objective: Telerehabilitation (TR) is now, in the context of COVID-19, more clinically relevant than ever as a major source of outpatient care. The social network of a patient is a critical yet understudied factor in the success of TR that may influence both engagement in therapy programs and post-stroke outcomes. We designed a 12-week home-based TR program for stroke patients and evaluated which social factors might be related to motor gains and reduced depressive symptoms.Methods: Stroke patients (n = 13) with arm motor deficits underwent supervised home-based TR for 12 weeks with routine assessments of motor function and mood. At the 6-week midpoint, we mapped each patient's personal social network and evaluated relationships between social network metrics and functional improvements from TR. Finally, we compared social networks of TR patients with a historical cohort of 176 stroke patients who did not receive any TR to identify social network differences.Results: Both network size and network density were related to walk time improvement (p = 0.025; p = 0.003). Social network density was related to arm motor gains (p = 0.003). Social network size was related to reduced depressive symptoms (p = 0.015). TR patient networks were larger (p = 0.012) and less dense (p = 0.046) than historical stroke control networks.Conclusions: Social network structure is positively related to improvement in motor status and mood from TR. TR patients had larger and more open social networks than stroke patients who did not receive TR. Understanding how social networks intersect with TR outcomes is crucial to maximize effects of virtual rehabilitation.
Synthesis and Preliminary Evaluation of a Novel 18F-Labeled 2-Nitroimidazole Derivative for Hypoxia Imaging
Authors: Lu Jing , Zhang Chi , Yang Xi , Yao Xi-Juan , Zhang Qun , Sun Xin-Chen 
Published: February 2021

ObjectiveHypoxia is prevalent in tumors and plays a pivotal role in resistance to chemoradiotherapy. 18F-MISO (18F-labeled fluoromisonidazole) is currently the preferred choice of PET hypoxia tracers in clinical practice, but has severe disadvantages involving complex labeling methods and low efficient imaging due to lipophilicity. We aimed to design a novel nitroimidazole derivative labeled by 18F via a chelation technique to detect hypoxic regions and provide a basis for planning radiotherapy.Materials and MethodsFirst, we synthesized a 2-nitroimidazole precursor, 2-[4-(carboxymethyl)-7-[2-(2-(2-nitro-1H-imidazol-1-yl)acetamido)ethyl]-1,4,7-triazanonan-1-yl]acetic acid (NOTA-NI). For 18F-labeling, a 18F solution was reacted with a mixture of AlCl3 and NOTA-NI at pH 3.5 and 100°C for 20 min, and the radiochemical purity and stability were evaluated. Biological behaviors of Al18F-NOTA-NI were analyzed by an uptake study in ECA109 normoxic and hypoxic cells, and a biodistribution study and microPET imaging in ECA109 xenografted mice.ResultsAl18F-NOTA-NI required a straightforward and efficient labeling procedure compared with 18F-MISO. The uptake values were distinctly higher in hypoxic tumor cells. Animal studies revealed that the imaging agent was principally excreted via the kidneys. Due to hydrophilicity, the radioactivities in blood and muscle were decreased, and we could clearly distinguish xenografted tumors from para-carcinoma tissue by PET imaging.ConclusionsThe nitroimidazole tracer Al18F-NOTA-NI steadily accumulated in hypoxic areas in tumors and was rapidly eliminated from normal tissue. It appears to be a promising candidate for hypoxia imaging with high sensitivity and resolution.
Case Report: Pseudoprogression With Nivolumab and Bevacizumab Followed by Recurrent Immune-Related Pneumonitis in Urothelial Carcinoma With Lung Metastasis
Authors: Yang Zizhong , Zhang Guoqing , Sun Qiong , Liu Minglu , Shao Jiakang , Jiao Shunchang 
Published: February 2021

BackgroundCombination therapy with immune checkpoint inhibitors (ICIs) and antiangiogenic agents is generally effective and well tolerated and might be effective for metastatic urothelial carcinoma (UC). However, ICI treatment is often associated with unique responses, such as pseudoprogression and ICI-related pneumonitis (CIP), which may influence clinical decision making and affect treatment. Although there have been many studies on the mechanism of pseudoprogression and CIP, the characteristics and relationship of these special events in a clinical setting remain rarely reported.Case PresentationHere, we present a patient with lung metastatic UC who underwent surgery and two lines of chemotherapy. The programmed cell death-1 (PD-1) inhibitor nivolumab and antiangiogenics agent bevacizumab were used as maintenance treatments. The patient experienced pseudoprogression after 2 PD-1 inhibitor cycles. The lesions in both lungs were enlarged on computed tomography (CT) imaging, and treatments were continued for another two cycles, after which the tumor size decreased to below baseline, followed by a durable response. However, after 4 months of pseudoprogression, the patient then developed CIP. The CIP was responsive to glucocorticoid therapy but recurred during ICI rechallenge, leading to the termination of immune therapy. Ultimately, the patient achieved durable, stable disease for over 18 months without further anticancer treatment.ConclusionsOur case shows that pseudoprogression can occur in UC during immunotherapy even when combined with an effective antiangiogenic agent. In addition, pseudoprogression may be correlated with future adverse effects and a durable response. In the management of CIP, early rechallenge with ICIs may lead to CIP recurrence, which could be more severe and needs to be treated early and with appropriate drugs. Clinicians should be aware of atypical responses to ICIs and adjust the treatment plan accordingly.
Case Report: Investigation of the Time Evolution of Optical Breakdown Plasma During Irradiation of Aqueous Solutions of Fe Nanoparticles
Authors: Baimler Ilya V. , Chevokin Viktor K. , Podvyaznikov Vitaliy A. , Gudkov Sergey V. 
Published: February 2021

The time sweeps of images of optical breakdown plasma flashes under irradiation of aqueous solutions of Fe nanoparticles with Nd: YAG laser radiation (λ = 1,064 nm, τ = 10 ns, ν = 10 kHz, ε = 2 mJ) are studied. It is shown that the sizes of plasma flares, the plasma glow intensity, and the time to reach the maximum intensity are concentrated around certain values. So, for example, the values of 30 μm are most typical for the maximum size of flares. The maximum luminescence is usually reached in 3–4 ns. It is found that at initial stage of optical breakdown process the water-vapor boundary moves at typical speed of 11 km/s and have maximum and minimum values at 15 and 4 km/s respectively. It is assumed in this work that such a distribution may be associated with the initiation of breakdown on nanoparticles located in different places of the laser radiation waist.
Manzuaat wa Musharadat, Uprooted and Scattered: Refugee Women Escape Journey and the Longing to Return to Syria
Authors: Rizkalla Niveen , Adi Suher , Mallat Nour Khaddaj , Soudi Laila , Arafa Rahma , Segal Steven P. 
Published: February 2021

ObjectiveViolent conflict forced millions of Syrians to flee their homes to host countries. This study examines Syrian refugee women’s experiences from the war’s outset through their journey to Jordan. It addresses the toll this journey had on their lives.MethodsTwenty-four in-depth interviews were completed with Syrian refugee women who currently reside in urban areas of Jordan. Researchers translated, transcribed, and analyzed the interviews using group narrative methodology.ResultsThe Syrian women had unique nostalgic memories of times before the war. They experienced atrocities during the war that forced their decision to escape Syria. Their journey narratives testify of internal displacement, personal and collective traumatic journeys via legal and illegal routes. Almost all the women were placed in refugee camps during their transitions to host country residency. In Jordan, they faced diverse hurdles of displacement and extremely different realities compared to the ones they had in Syria. Despite how very different but difficult each of their journeys were, every single woman longed to return home to Syria.ConclusionsThis study presents a new understanding of the role and process of the journeys undertaken and highlights the concept of “return” as the defining element for Syrian refugee women. Regardless of the hardships women endured to escape their homeland to find safety, “return” marks an ending to their horror journey and the beginning of a new journey of hope for a better future.
Implementing an Action Over Inertia Group Program in Community Residential Rehabilitation Services: Group Participant and Facilitator Perspectives
Authors: Rees Erin F. , Ennals Priscilla , Fossey Ellie 
Published: February 2021

Introduction:A time-use focused intervention, Action Over Inertia (AOI) designed to address restricted activity patterns and support recovery, was adapted for use in Australian community residential mental health services.Method:Qualitative case study research explored the use of AOI groups across three Community Care Units from the perspectives of group participants with enduring mental illness and group facilitators. Fifteen interviews were conducted: five group participants were interviewed twice 4 weeks apart, and five group facilitators on completion of the group intervention. Interview data were analyzed thematically using constant comparative methods.Findings:Two overarching themes, “Making Change” and “Facilitating Change” were identified. Efforts to make change in their lives were supported by participants recognising the value of personally meaningful activities for well-being and of activity experiences that fostered hope and recovery, whereas a sense of “stuckness,” time for activities and life events could disrupt “getting me going.” For the facilitators, facilitating change involved recognizing inertia as a challenge; getting people going; and looking at how AOI intervention works to impact inertia.Conclusion:AOI in a group format supports participants to identify barriers to more active living; to appreciate how time-use and well-being interrelate; and to reframe and take steps to overcome inertia. Further research should evaluate AOI groups as a means of providing individualized support for activity re-engagement as part of recovery oriented mental health rehabilitation.
Comment Proust fut autorisé à exercer la pharmacie (1820)
Authors: Fournier Josette 
Published: February 2021

How Proust was authorized to practise pharmacy (1820) – According to Dr. David (1938) Proust was authorized by the École de pharmacie de Paris (1820) to practise pharmacy after his brother’s death, though he did not achieve his formation (Fournier, 1999) as gagnant-maîtrise of the Salpêtrière hospital. This authorization has never been localized until the discovery (AD 49) of a set of independant papers from Proust himself, of the prefect and of the medical departmental jury which
confirm it existence.
Клиничен случай на пациент с Болест на Стил – диагностично предизвикателство или закъсняла диагноза?
Authors: Emin Soner , Boyadzhieva Vladimira , Stoilov Nikolay , Stoilov Rumen 
Published: February 2021

Болестта на Стил при възрастни представлява рядко системно автоинфламаторно заболяване с недобре изяснена етиология, характеризиращо се с ежедневни температурни пикове, полиартрит и преходен макуло-папулозен обрив с цвят на сьомга. Екстремно високи нива на феритин се наблюдават при голям процент от болните, което го прави важен лабораторен тест при поставяне на диагнозата. Болестта на Стил при възрастни е важен диагностичен и терапевтичен проблем, който в редица случаи остава неразпознат поради рядкостта в популацията и разнообразната клинична картина. Представяме ви клиничен случай на 34-годишна жена, с първа изява - обрив по дорзалната повърхност на двете гривнени стави и в областта на двете коленни стави, по време на първа бременност в 6-та гестацинонна седмица. При гинекологичен преглед се установява интраутеринна смърт на плода, което е наложило преждевременно прекъсване на бременността в 8-ма гестационна седмица. По същото време пациентката съобщава за поява на фебрбилитет до 39°C. На фона на започната комбинирана антибиотична терапия, при болната се наблюдават персистиращи фебрилни епизоди с втрисане и тенденция към повишаване на острофазовите показатели. Пациентката е хоспитализирана в нефрологично отделение в увредено общо състояние, където е проведена комбинирана антибиотична и кортикостероидна терапия без задоволителен ефект. При пациентката е установен двукратно отрицателен резултат от PCR-тест за COVID-19. От проведените микробиологични изследвания за бактериални, вирусологични и гъбични инфекции, се доказа повишен титър на IgG- антитела за бруцелоза. Инфекцията е потвърдена от положителен PCR-тест в Клиника по инфекциозни болести и назначен 2-месечен антибиотичен курс с Доксициклин 200мг/дневно, на фона на който фебрилитетът персистира. Болната се хоспитализира в Клиника по Ревматология “ УМБАЛ “ Св. Ив. Рилски” в увредено общо състояние, с неясно фебрилно състояние до 39°С, полиартралгии, полимиалгии, макулозен еритемен обрив в областта на гърдите, левкоцитоза, тромбоцитоза, повишени LDH, феритин, ГГТ, острофазови показатели, микроцитна, хипохромна анемия, отрицателни имунологични изследвания (анти-MCV, анти-ССР, ANA-screen, ANA-blot, anti-dsDNA, ANCA, anti-MPO, anti-PR3, аCL, antiB2GPI, anti-Protrombin), Quantiferon (-) отр. При пациентката се прие диагноза Болест на Стил и се започна лечение с Метилпреднизолон 60 мг/дневно, на фона на който се наблюдава трайно афебрилно състояние и значително подобрение в клиничното състояние и лабораторните показатели.
PENGARUH PEMBACAAN AL-QURAN BIN NAGHAM (TILAWAH) PADA KETENANGAN JIWA SANTRI PONPES LSQ AR-RAHMAH BANTUL
Authors: Rosyidin Andy 
Published: February 2021

The Qur'an is interesting to study because it has secrets that many people don't know about without being aware of. One of them is about the element of ash-Shifa, namely the Koran as a medicine / antidote as stipulated in the Koran Surah Al-Isra ': 82. In some interpretations the purpose of the drug or the antidote is not limited to disturbances in the body but dzohir / physical also feltthe presence of these miracles. Various methods can be done by someone to get the miracle of al-Qur'an as ash-Shifa, one of them is by reciting the Qur'an method. Namely reading the Koran by using tones and charts (tausyih) which have been commonly used in MTQ starting from method. Namely reading the Koran by using tones and charts (tausyih) which the baby and its derivation to the level of the Jiharkah song. In processing this article the authors used a descriptive-qualitative method that is by describing the evidence that the Qur'an read by the recitation method has an influence on the psychology (peace of mind) of readers and listeners. Then use interviewtechniques as a data collection. As for the scope of this study, the author focuses on the students at the Islamic Boarding School LSQ ar-Rahmah Bantul Yogyakarta.
A Trace of Similarity within Even Greater Dissimilarity
Authors: Tabaczek Mariusz 
Published: February 2021

This article readdresses the Przywara-Barth controversy concerning analogia entis. The main point of our analysis is the question of whether the concept of analogy presented by Erich Przywara was in line with the classical Aristotelian-Thomistic definition and use of analogy in theistic predication. First, we ask about Przywara’s strong conviction that analogy is primarily a metaphysical and not merely a grammatical doctrine. Secondly, after presenting the complexity of Aquinas’ notion of analogy, as well as the variety of opinions on this subject among his commentators, we analyze (1) the objectives of Przywara’s view of analogia entis, (2) his grounding it in the terminology taken from the typology offered by Cajetan and juxtaposing analogia proportionalitatisand analogia atributionis, and (3) his introduction of the concept of “a new ‘attributive analogy’”, proceeding form above to below and sustaining the tension within analogia entis. We show that Przywara remained a faithful student and interpreter of Thomas, which makes Barth’s accusation that the Catholic doctrine of analogia entisputs God and creatures on a common plane of being, unjustified.