bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of gravity and geospatial data to determine geological hazard prospect zones in the Halmahera, North Molucca using GIS Weighted Overlay Index (WOI) method
Authors: Aprina P U , Santoso D , Alawiyah S , Prasetyo N 
Published: December 2024

Abstract
Halmahera Island is one of the Indonesian archipelagos that formed from the interaction among three major plates, Indo-Australian, Eurasia, and Pacific. This convergence causes Halmahera Island presumably to be a geological hazard susceptibility area. This study used gravity data to delineate subsurface structure based on the Euler Deconvolution technique and further combined with various geospatial data, including lineament density extracted from Sentinel-1A imagery, rainfall rate, PGA, and vegetation index (NDVI) derived from optical imagery processing, to generate a geological hazard potential zone map based on the Geographic Information System (GIS) implementation. Each thematic map is weighted using the Analytical Hierarchy Process (AHP) approach, normalized by the Weighted Overlay Index (WOI) technique, and summed up to calculate the Hazard Potential Index (HPI). The calculated map is ranked and reclassified as the most and least dangerous zone of geological hazard vulnerability. HPI shows the most dangerous area is located in several places, including the north and south arms of Halmahera with an index of 0.63 and 0.51, respectively, while the lowest potential zone is in the southeast arm (0.15). The outcome of this mapping is presumably to be used as a hazard mitigation reference henceforward.
Effect of Salt Addition on Sedimentation Rate and Mine Wastewater Quality
Authors: Norfaeda R , Kartini  , Saptarini D L , Fajar R A 
Published: December 2024

Abstract
Prediction of sedimentation rate is one of the efforts to carry out good ex-mining water treatment. The sedimentation rate can be accelerated by the addition of chemical and biological additives, one of which is the addition of salt.
The purpose of this study was to determine the relationship between the addition of salt content to the sedimentation rate and its effect on the quality of wastewater produced by settling ponds. The sample used is a solution made from coal seam overburden dissolved in water as a representative sample of waste water that flows into the settling pond. The sample solutions were added of 10%, 20% and 30% of salt from total solid. The sedimentation rate and water quality parameters of the salt solution were measured using a Multiparameter tool.
Addition of salt with a concentration of 30% was the fastest, with a sedimentation rate of 6.25 x 10−5 m/s, for 20% and 10%, respectively, of 5.83 x 10−5 m/s. Based on 3 experiments were concluded that the optimal salinity value in accelerating the sedimentation rate with good water quality was 20%. This research indicates that more salt content will accelerate the sedimentation rate but will affect the water quality in terms of increasing the pH to become more alkaline and increasing the salinity in the water.
Enhancing the efficiency of hybrid Schottky diode by decoration of 2D Cs:ZnO nanosheets with CNTs via a facile co-precipitation approach
Authors: Al-Sayed A , Siddiq Miad Ali , Elgazzar Elsayed 
Published: December 2024

Abstract
The Cs:ZnO@CNTs nanocomposite was synthesized by chemical co-precipitation method and characterized using XRD, EDX, SEM, and TEM techniques, which revealed small crystalline size, high atomic density, and large surface area. The thin films showed intense optical absorption near the visible region with optical band gaps of 3.12 eV and 3.06 eV for Cs:ZnO and Cs:ZnO@CNTs nanostructures, respectively. The hybrid Schottky diode was fabricated by depositing Cs:ZnO nanosheets on p-Si using drop casting technique and the metal contacts were thermally deposited via thermal evaporation technique. The electronic parameters were evaluated in a dark environment, revealing reduced series resistance

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R

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and a decreased potential barrier

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relative to the undoped diode. The photodiode demonstrated elevated responsivity and specific detectivity under illumination conditions influenced by CNT additions, which expanded optical absorption and increased photocarrier density. The

C
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V

and

R

s

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V

measurements were executed over a wide frequency range, indicating the significant impact of trapped centers at interfacial layers on capacitance, conductance, and series resistance characteristics. The obtained results confirmed the potential use of hybrid photoactive materials in the development of solar power devices.
Methods for estimating beneficiary populations targeted by health and nutrition interventions for women, pregnant women, infants, and young children
Authors: Gune Soyra , Nguyen Phuong H , Chakrabarti Suman 
Published: December 2024

Abstract
Utilization of maternal and child interventions is typically tracked in low- and middle-income countries (LMICs) using coverage estimates from population representative surveys. These estimates cannot be directly applied to assess resource gaps in intervention delivery for which data on the population eligible is required. Moreover, coverage improvements may not necessarily reflect an expansion in utilization because of a decline in the population eligible. We develop a method to estimate the populations eligible for interventions across the continuum of care. The method uses data from the World Population Prospects and the Demographic Health Survey, data sources which are available for most LMICs. Additionally, we develop a method to estimate the eligible population covered by each intervention. Using the illustration of India, we estimate populations eligible for, and covered by interventions during preconception, pregnancy, delivery, lactation, and childhood. We find that between 2015 and 2020, the eligible population declined for all beneficiary groups. Additionally, coverage expansion was not entirely driven by an increase in the population accessing an intervention, but rather also by a decline in the eligible population. Our illustration highlights the importance of including population estimates alongside coverage for interventions, particularly in LMIC contexts due to changing fertility dynamics.
Male Chest Athletic Definition: A Comprehensive View from an Anatomical and Physiological Perspective
Authors: Mera-Cruz Giovanni , Murillo-Romero Natalia , Barragán-Guadalupe Carlos , Duran Michael , Camacho-Domínguez Laura , Guio-Gómez Yulia Daniela , Mera-Herrera Isabella 
Published: December 2024

Abstract

Background
In order to obtain a natural but athletic contour through liposuction, the management of the male pectoral region is constantly changing. Cutting-edge methods including mammary gland excision and fat grafting to the pectoralis major have been created. There isn't yet a single method that can handle all long-term problems, like gynecomastia with eventual loss of pectoral definition, fat graft asymmetries, and/or unnatural definition..vic

Objectives
This article proposes a surgical technique to improve the male pectoral region through liposuction in specific areas, muscular volumization with objectively established fat volumes based on intracompartimental pressure measurements, and the management and prevention of gynecomastia. This approach aims to ensure the maximal survival of the fat graft with reduced fat necrosis, long-term asymmetry, and sustained results over time.

Methods
Measurement of the pectoralis major pressure, following fat graft, was conducted between January 2021 and June 2023. Patients aged between 19 and 60 years at the time of surgery, with a body mass index below 30 kg/m², were included. The surgical technique is presented in this article.

Results
The two models used in this study exhibited strong explanatory power, indicating that a significant portion of the variability in fat graft resorption could be explained by the variables included in these models. Postoperative exercise, patients age, and intramuscular pressure of the transferred fat showed statistically significant results in the survival of fat grafts. BMI did not show a statistically significant relationship.

Conclusions
This technique can treat and prevent gynecomastia while simultaneously improving the appearance of the male chest through volumization of the pectoralis major with safe fat grafts volumes. The established volumes did not exceed 8 mmHg intracompartimental pressure. Higher volumes reduced fat survival. Large volumes lead to greater postoperative asymmetry and loss of fat grafts
PAGE-based transfer learning from single-cell to bulk sequencing enhances model generalization for sepsis diagnosis
Authors: Jin Nana , Nan Chuanchuan , Li Wanyang , Lin Peijing , Xin Yu , Wang Jun , Chen Yuelong , Wang Yuanhao , Yu Kaijiang , Wang Changsong , Chen Chunbo , Geng Qingshan , Cheng Lixin 
Published: December 2024

Abstract
Sepsis, caused by infections, sparks a dangerous bodily response. The transcriptional expression patterns of host responses aid in the diagnosis of sepsis, but the challenge lies in their limited generalization capabilities. To facilitate sepsis diagnosis, we present an updated version of single-cell Pair-wise Analysis of Gene Expression (scPAGE) using transfer learning method, scPAGE2, dedicated to data fusion between single-cell and bulk transcriptome. Compared to scPAGE, the upgrade to scPAGE2 featured ameliorated Differentially Expressed Gene Pairs (DEPs) for pretraining a model in single-cell transcriptome and retrained it using bulk transcriptome data to construct a sepsis diagnostic model, which effectively transferred cell-layer information from single-cell to bulk transcriptome. Seven datasets across three transcriptome platforms and fluorescence-activated cell sorting (FACS) were used for performance validation. The model involved four DEPs, showing robust performance across next-generation sequencing and microarray platforms, surpassing state-of-the-art models with an average AUROC of 0.947 and an average AUPRC of 0.987. Analysis of scRNA-seq data reveals higher cell proportions with JAM3-PIK3AP1 expression in sepsis monocytes, decreased ARG1-CCR7 in B and T cells. Elevated IRF6-HP in sepsis monocytes confirmed by both scRNA-seq and an independent cohort using FACS. Both the superior performance of the model and the in vitro validation of IRF6-HP in monocytes emphasize that scPAGE2 is effective and robust in the construction of sepsis diagnostic model. We additionally applied scPAGE2 to acute myeloid leukemia and demonstrated its superior classification performance. Overall, we provided a strategy to improve the generalizability of classification model that can be adapted to a broad range of clinical prediction scenarios.
Immune-related genes for the prediction of response to imatinib therapy in chronic myeloid leukemia
Authors: Yang Pu , Yu Qian 
Published: December 2024

Abstract
Chronic myeloid leukemia (CML) is a malignant hyperplastic tumor that originates from pluripotent hematopoietic stem cells in the bone marrow. The introduction of tyrosine kinase inhibitors has significantly improved the survival rates of CML patients. This study aimed to identify immune-related genes associated with the response to imatinib (IM) therapy in CML. Gene expression profiles from IM-treated CML patients were obtained from the Gene Expression Omnibus database and categorized into high- and low-score groups based on immune scores calculated using the ESTIMATE algorithm. Subsequent bioinformatics analysis identified 428 differentially expressed immune-related genes in the CML context. Functional enrichment analysis revealed that these genes were involved in immune-related pathways, including T-cell receptor signaling and cytokine–cytokine receptor interaction. Finally, based on five modules in weighted gene co-expression network analysis and the top-ranked degree, 10 hub genes were identified. Receiver operating characteristic analysis in two Gene Expression Omnibus datasets identified IL10RA, SCN9A, and SLC26A11 as potential biomarkers for predicting IM response. We further validated these biomarkers in an independent clinical cohort of 60 CML patients treated with IM. Results from quantitative real-time polymerase chain reaction (qRT-PCR) revealed high expression of IL10RA and SLC26A11 in responders, while SCN9A showed low expression. All three genes had an area under the curve greater than 0.75, confirming their potential as predictive biomarkers. These findings deepen our understanding of functional characteristics and immune-related molecular mechanisms underlying IM response and offer promising predictive biomarkers.
Defying Uganda’s morality police: the grammar of social media protest images
Authors: Ssozi Javie , Dowling David O 
Published: December 2024

Abstract
This study examines the social media movement protesting Uganda’s 2014 Anti-Pornography Act (APA) designed to regulate women’s attire. The legislation fueled mob attacks on women wearing miniskirts in public, sparking public protests documented with images of demonstrators bearing placards voicing their dissent. Unlike the traditional public sphere where gatekeeping remains pervasive and entrenched, social media’s loosely regulated platforms give interested users unabated access to issues and the public. Images, text, and hashtags play a vital role in conveying grievances. Through critical discourse analysis (CDA) relevant to communication through images, findings reveal how the circulation of protest images online shapes public opinion and legislative outcomes on contested issues such as sex, morality, and women’s rights. The images operationalize a visual grammar of resistance that negotiates and contests the meaning of women’s bodies in defiance of the repressive government.
Detection of antibodies to infliximab in routine care: a 4-year French retrospective study
Authors: Bertin Daniel , Aghzadi Jehanne , Balandraud Nathalie , Roman Céline , Serrero Mélanie , Desplat-Jégo Sophie 
Published: December 2024

Abstract
Despite its wide use to treat various inflammatory diseases, infliximab becomes ineffective in some patients due to inadequate drug levels and production of anti-drug antibodies (ADA). The aim of this study was to compare the prevalence and ADA levels in a large cohort of patients. ADA and infliximab (IFX) through levels measured by enzyme-linked immunosorbent assay were collected from 505 patients within a period of 4 years. The results indicate that (i) 13.5% of patients produce ADA, (ii) male patients were more likely to produce ADA at levels above 10 000 ng/ml than female patients, (iii) ADA levels were lower when associated with immunosuppressant drugs, (iv) there was an inverse relationship between ADA presence and IFX detection, and (v) no correlation was observed between ADA levels and number of injections or brand of IFX administered. This study improves our understanding of the factors promoting IFX immunogenicity and highlights the need to develop personalized treatment strategies.
Asymmetrical patterns of β-amyloid deposition and cognitive changes in Alzheimer’s disease: the SILCODE study
Authors: Yu Xianfeng , Zhang Ying , Cai Yue , Rong Ning , Li Ruixian , Shi Rong , Wei Min , Jiang Jiehui , Han Ying 
Published: December 2024

Abstract
The asymmetric pattern of β-amyloid plaque distribution across Alzheimer’s disease clinical progression stages remains unclear. In this study, 66 participants with normal cognition, 59 with subjective cognitive decline, 12 with mild cognitive impairment, and 11 with Alzheimer’s disease dementia were included in the Sino Longitudinal Study on Cognitive Decline (SILCODE) cohort. A regional asymmetry index, denoting the left–right asymmetry of β-amyloid plaques, was derived for each region based on the Anatomical Automatic Labeling atlas. The level of β-amyloid plaques in each region was compared among different clinical stages of Alzheimer’s disease using the analysis of variance. An additional correlation analysis examined the relationship between each region of interest’s cognitive performance scores and asymmetry index values. We found that β-amyloid appears to be lateralized in different stages of Alzheimer’s disease. In addition, there is a significant correlation between β-amyloid asymmetry in various brain regions and cognition. The observed Aβ lateralization could potentially be utilized as a neuroimaging biomarker throughout AD progression.
The more eye-like, the more intimidating—visual illusion gives new evidence for the anti-predation mechanism of eyespots
Authors: Long Xiaoyu , Chen Qiuyang , Zhang Yigui , Zhao Yumeng , Cheng Yuwen , Li Zhongqiu 
Published: December 2024

Abstract
Eyespots have been shown to perform an anti-predator function by intimidating predators. However, whether predators are deterred by the eyespots’ mimicking eyes of higher-order predators, or by the conspicuousness of the spots, is still being debated. The anti-predator mechanism of eyespots, which involves the predator’s visual perception and cognition, urges to be examined. To explore the “eye mimicry hypothesis” and “conspicuous signal hypothesis,” we designed prey with deceptive eyespots eliciting 2-dimensional (2D) or 3-dimensional (3D) visual illusions for domestic chicks (as predators). For 2D visual illusion, we provided prey with occluded eyespots for chicks. Chicks can “complete” the occluded eyespots into a full 2D concentric circle by the amodal completion mechanism, that is, one of visual illusion. For 3D visual illusion, we created the crescent-shaped sparkles on the eyespots to simulate a visually 3D eye. Our result indicated that (1) 2D: chicks hesitated more when facing preys with occluded eyespots than facing preys with broken eyespots and (2) 3D: compared to prey with no-sparkle eyespots, chicks spent more time approaching prey with sparkle eyespots and were more likely to approach them tangentially. Thus, the visual illusion perceived by chicks would impact the anti-predation effectiveness of eyespots. Eyespots that more closely resemble the real eyes, especially those with 3-dimensionality, provided more effective protection. Our study supported the eye mimicry hypothesis from the perspective of visual illusion.
Interpretable predictive value of including HDL-2b and HDL-3 in an explainable boosting machine model for multiclass classification of coronary artery stenosis severity in acute myocardial infarction patients
Authors: Wang Bin , Li Dong , Geng Yu , Jin Feifei , Wang Yujie , Lv Changhua , Lv Tingting , Xue Yajun , Zhang Ping 
Published: December 2024

Abstract

Aims
The aim of this study was to use explainable boosting machine (EBM) to evaluate the predictive value of HDL-2b and HDL-3 levels in comparison with traditional lipid parameters in three-class classification of coronary artery stenosis severity in acute myocardial infarction (AMI) patients.

Methods and results
In this cross-sectional study, 1200 AMI patients were evaluated. HDL subtypes were quantified via microfluidic chip detection, and stenosis severity was assessed via the Gensini scoring system. The Gensini scores were divided into three groups: low group (&lt;36.5), moderate group (36.5–72), and high group (&gt;72). Explainable boosting machine, an interpretable machine learning technique, was employed to assess the predictive value of HDL-2b and HDL-3 compared with traditional lipid markers. Explainable boosting machine was used as the main model in this study, whereas logistic regression, XGBoost, and Random Forest were selected as reference models for predictive performance. Model performance was evaluated using receiver operating characteristic curves. The HDL-3 (%) values were divided into three risk categories: low (&gt;43), moderate (30–43), and high (&lt;30). The incorporation of HDL-2b and HDL-3 levels into lipid profiling significantly increased the group importance scores. The macro-average area under the curve values for the four models were as follows: 0.56 for the logistic model, 0.54 for the EBM model, 0.50 for the Random Forest model, and 0.49 for the XGBoost model.

Conclusion
HDL-3 provides superior predictive value for evaluating coronary artery stenosis severity in AMI patients compared to HDL-2b and other conventional lipid markers.
The Effects of Graded Levels of Calorie Restriction XXI: impact of short term graded restriction on gene expression profiles of stomach and skeletal muscle
Authors: Xia Fan , Wu Yingga , Li Min , Mitchell Sharon E , Speakman John R 
Published: December 2024

Abstract
Calorie restriction (CR) extends lifespan and prevents several aging related diseases. During short-term restriction, we previously showed that lean tissues generally decrease in size, but the alimentary tract (especially the stomach) grows. To illuminate pathway alterations in these contrasting tissues we compared gene expression profiles (bulk RNAseq) of the skeletal muscle and stomach, in the same male C57BL/6J mice exposed to 3 months of graded CR (0-40%). Transcriptomic analysis showed the numbers of differentially expressed genes (DEGs) relative to 12h ad libitum (12AL) feeding increased as the level of restriction increased. We found the canonical CR and aging related pathways, eukaryotic translation initiation factor 2 (EIF2) and mammalian target of rapamycin (mTOR), were significantly up- and downregulated respectively in gastrocnemius muscle, but less so in the stomach. These changes were consistent with the differential growth status of the two tissues under CR. However, various immune-related pathways such as pathogenesis of influenza and interferon signalling pathway were downregulated and the PD-1/PD-L1 cancer immunotherapy pathway was upregulated with increased CR level in the stomach, indicating an impaired ability of anti-virus and improvement of cancer treatment. Furthermore, in the mTOR and NF-kB aging related pathways, more genes in muscle tissue were significantly correlated with CR level than in the stomach and liver. Suggesting muscle is an important aging related tissue responding to caloric restriction. These two pathways were altered in a manner consistent with increased lifespan as CR level increased in both tissues.
Digital Determinants: The Inclusion of Social Media in Health Conceptualization
Authors: Wade Michelle Elaine , Parks Kortnie 
Published: December 2024

Abstract
Social determinants of health (SDOH) are vital components to helping address health equity and the social and economic factors that impact health and health outcomes. Two important aspects of SDOH to consider are informational access and accuracy. In an era increasingly influenced by digital platforms, this study delves into the significant role of social media as an SDOH. Through an exploratory sequential mixed-methods design, this study captures mental health professionals’ perspectives regarding the professional use of social media. The findings of this study reveal a need for further guidance on how to professionally utilize social media and address boundary and confidentiality concerns. Additionally, the findings demonstrate that social media could be a valuable tool for health education, community support, and public health messaging, and highlights a necessity for accurate informational accessibility. This study underscores the need for a nuanced understanding of social media’s role in health, advocating for informed and strategic use in mental health practice.