bluuebunny/crossref_metadata_2025_split huggingface dataset:
An oxidative metabolic pathway of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU) from alginate in an alginate-assimilating bacterium
Authors: Nishiyama Ryuji , Ojima Takao , Ohnishi Yuki , Kumaki Yasuhiro , Aizawa Tomoyasu , Inoue Akira 
Published: November 2021

AbstractAlginate-assimilating bacteria degrade alginate into an unsaturated monosaccharide, which is converted into 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU). DEHU is reduced to 2-keto-3-deoxy-D-gluconate by a DEHU-specific reductase using NAD(P)H. This is followed by pyruvate production via the Entner-Doudoroff pathway. Previously, we identified FlRed as a DEHU reductase in an alginate-assimilating bacterium, Flavobacterium sp. strain UMI-01. Here, we showed that FlRed can also catalyze the oxidation of DEHU with NAD+, producing 2-keto-3-deoxy-D-glucarate (KDGR). FlRed showed a predilection for NADH and NAD+ over NADPH and NADP+, respectively, and the Km value for NADH was approximately 2.6-fold less than that for NAD+. Furthermore, we identified two key enzymes, FlDet and FlDeg, for KDGR catabolism. FlDet was identified as an enzyme of the ribonuclease activity regulator A family, which converts KDGR to α-ketoglutaric semialdehyde (α-KGSA). FlDeg, a type II α-KGSA dehydrogenase, generated α-ketoglutaric acid by oxidizing the aldehyde group of α-KGSA using NAD(P)+. Consequently, unlike the conventional DEHU reduction pathway, DEHU can be directly converted to α-ketoglutaric acid without consuming NAD(P)H. Alginate upregulated the expression of not only FlRed and two enzymes of the DEHU-reduction pathway, but also FlDet and FlDeg. These results revealed dual pathways of DEHU metabolism involving reduction or oxidation by FlRed.
Innovative Angebote für Menschen mit Demenz in Deutschland
Authors: Ziegert Nadja , Hofbauer Lena , Rodriguez Francisca S. 
Published: November 2021

ZUSAMMENFASSUNGGegenstand und Ziel Das Bedürfnis nach einer Optimierung der Versorgung von Demenzerkrankungen hat in Deutschland zu diversen innovativen neuen Ansätzen geführt, welche beispielsweise mithilfe psychosozialer, kultureller, aber auch digitaler Methoden dazu beitragen wollen, das Wohlbefinden von Menschen mit Demenz zu verbessern. Ziel der vorliegenden Arbeit ist es, innovative Angebote für Menschen mit Demenz vorzustellen, um die Potenziale und die Vielfalt abseits von gegenwärtigen pflegerischen und medizinischen Angeboten in Deutschland aufzuzeigen.Material und Methoden Mithilfe einer Internetsuche wurde systematisch auf Bundesebene nach Angeboten für Menschen mit Demenz recherchiert.Ergebnisse Es wurden 50 demenzsensible Angebote identifiziert. Diese teilen sich in 39 direkte Angebote für Menschen mit Demenz und 11 demenzsensible Angebote für Berufsgruppen in der Versorgung auf.Schlussfolgerung Die Ergebnisse zeigen, dass es vielfältige demenzsensible Angebote gibt, die die medizinisch-pflegerische Versorgung ergänzen, aber auch unabhängig davon Demenzerkrankte in unsere Gesellschaft einbinden und sie teilhaben lassen.
Auswirkungen der COVID-19-Pandemie auf neuropsychiatrische Symptome von Menschen mit Demenz und die psychische Gesundheit ihrer pflegenden Angehörigen
Authors: Dominke Clara , Wei Grace , Piguet Olivier , Kumfor Fiona , Diehl-Schmid Janine 
Published: November 2021

ZUSAMMENFASSUNG
Ziel Diese Studie hatte zum Ziel, die Auswirkungen der COVID-19-Pandemie sowie der damit einhergehenden Einschränkungen (Ausgangsbeschränkungen, Social Distancing) auf neuropsychiatrische Symptome von Menschen mit Demenz sowie die psychische Gesundheit ihrer pflegenden Angehörigen in Deutschland zu untersuchen.
Methoden Pflegende Angehörige beantworteten einen Online-Fragebogen zu den Auswirkungen der COVID-19-Pandemie auf neuropsychiatrische Symptome von Menschen mit Demenz sowie auf die eigene psychische Gesundheit.
Ergebnisse 78 pflegende Angehörige nahmen an der Studie teil. Seit Beginn der Pandemie litten Menschen mit Demenz vermehrt unter neuropsychiatrischen Symptomen wie Apathie, Depression, Angst und Agitation. Das Getrenntleben von dem Angehörigen war mit einer Verschlechterung der depressiven Symptomatik des Patienten assoziiert. Ein besseres Verständnis der Situation auf Seiten des Menschen mit Demenz war hingegen mit einem geringeren Risiko verbunden. 51,3 % der befragten Angehörigen berichteten außerdem von einer Verschlechterung der eigenen psychischen Gesundheit. Gesteigerte Zukunftssorgen und das Gefühl von Einsamkeit seit dem Ausbruch der Pandemie standen in Zusammenhang mit dieser Verschlechterung.
Schlussfolgerungen Um eine Zunahme neuropsychiatrischer Symptome von Menschen mit Demenz und der Beeinträchtigung der psychischen Gesundheit von pflegenden Angehörigen entgegenzuwirken, sollten zukünftige Public-Health-Maßnahmen die individuellen Bedürfnisse dieser Gruppen zwingend berücksichtigen. Zusätzliche individuelle Unterstützungsangebote werden z. B. von der Mehrheit der Befragten als hilfreich bewertet und könnten die schädlichen psychologischen Effekte der Pandemie abmildern.
Planetary well-being
Authors:   JYU.Wisdom community, Kortetmäki Teea , Puurtinen Mikael , Salo Miikka , Aro Riikka , Baumeister Stefan , Duflot Rémi , Elo Merja , Halme Panu , Husu Hanna-Mari , Huttunen Suvi , Hyvönen Katriina , Karkulehto Sanna , Kataja-aho Saana , Keskinen Kirsi E. , Kulmunki Inari , Mäkinen Tuuli , Näyhä Annukka , Okkolin Mari-Anne , Perälä Tommi , Purhonen Jenna , Raatikainen Kaisa J. , Raippalinna Liia-Maria , Salonen Kirsi , Savolainen Katri , Kotiaho Janne S. 
Published: November 2021

AbstractTensions between the well-being of present humans, future humans, and nonhuman nature manifest in social protests and political and academic debates over the future of Earth. The increasing consumption of natural resources no longer increases, let alone equalises, human well-being, but has led to the current ecological crisis and harms both human and nonhuman well-being. While the crisis has been acknowledged, the existing conceptual frameworks are in some respects ill-equipped to address the crisis in a way that would link the resolving of the crisis with the pivotal aim of promoting equal well-being. The shortcomings of the existing concepts in this respect relate to anthropocentric normative orientation, methodological individualism that disregards process dynamics and precludes integrating the considerations of human and nonhuman well-being, and the lack of multiscalar considerations of well-being. This work derives and proposes the concept of planetary well-being to address the aforementioned conceptual issues, to recognise the moral considerability of both human and nonhuman well-being, and to promote transdisciplinary, cross-cultural discourse for addressing the crisis and for promoting societal and cultural transformation. Conceptually, planetary well-being shifts focus on well-being from individuals to processes, Earth system and ecosystem processes, that underlie all well-being. Planetary well-being is a state where the integrity of Earth system and ecosystem processes remains unimpaired to a degree that species and populations can persist to the future and organisms have the opportunity to achieve well-being. After grounding and introducing planetary well-being, this work shortly discusses how the concept can be operationalised and reflects upon its potential as a bridging concept between different worldviews.
Responsible Research and Innovation Training Programs: Implementation and Evaluation of the HEIRRI Project
Authors: Tokalić Ružica , Buljan Ivan , Mejlgaard Niels , Carrió Mar , Lang Alexander , Revuelta Gema , Marušić Ana ,   HEIRRI Consortium
Published: November 2021

ABSTRACT
Responsible research and innovation, or RRI, is a concept that aims to bring together society and science for a better future. There are six key elements of RRI: public engagement, gender equality, science education, open access, ethics and governance. Higher Education Institutions and Responsible Research and Innovation (HEIRRI) project aimed to bring the concept of RRI into the educational system. Using state-of-the-art review of good practices, HEIRRI team developed 10 training programs on RRI for different higher education institution educational levels, including a summer school and a massive open online course (MOOC). We conducted pilot of the trainings and evaluated participants’ experiences. Satisfaction with HEIRRI training programs on responsible research and innovation was high, both for participants and for the trainers, and trainings raised awareness of RRI. Participants’ feedback was used to identify areas that need improvement and provided for recommendations for final versions of the HEIRRI training programs. In order to equip researchers with skills to recognize and apply RRI values, RRI should be included in their education. HEIRRI training is suitable for a range of different disciplines, including forensic science, and is free to use and adjust for specific contexts (available from: https://rri-tools.eu/heirri-training-programmes). KEY POINTSRRI aims to make research inclusive, responsible, reflexive and to foster integrity of researchersHEIRRI project developed a toolbox of engaging activities for introduction of RRI concepts in higher educationHEIRRI training can be used to introduce RRI at all levels of higher education and members of the publicHEIRRI training is suitable for a range of different disciplines, including forensic science, and is free to use and adapt
Water storage and agricultural resilience to drought: historical evidence of the capacity and institutional limits in the United States
Authors: Smith Steven M , Edwards Eric C 
Published: November 2021

AbstractFood systems are particularly sensitive to changing precipitation patterns. Resilience via irrigation will depend on baseline conditions, water source, and institutional constraints which have not been studied jointly. We draw on over 100 years of agricultural production and weather data across the United States to identify the extent to which access to stored water—distinguished by its source and location—affects drought resiliency. Arid regions with access to stored water avoided the 13% losses in crop value experienced in irrigated areas with more limited storage during droughts. Humid regions are also beginning to adopt irrigation, but with less aggregate impact during drought. The incomplete governance of groundwater withdrawals in many areas allow resiliency in the near-term, but potentially at the expense of future water availability. Conversely, surface water rights allow for the widespread application of irrigation water, but with less resiliency during significant periods of drought.
Spatial Regression Modelling Impact of Population Movement Intensity and Land Use to Air Temperature in Semarang City, Indonesia
Authors: Widjonarko W. , Maryono M. 
Published: November 2021

Abstract
The built-up area and the number of population mobility are used to indicate urban growth. Many research’s found that number of population mobility which use motorized vehicle has contributed in increasing exhaust emissions in the air, and have an impact on air temperature, and so does the built-up area. The built-up area made the ability of the environment to absorb heat decreased. This phenomenon is also occurred in Semarang. Spatial regression modelling is use to describe the contribution of land use and population movement to Land Surface Temperature (LST) in Semarang City. Based on the spatial regression analysis, a spatial model of the effect of population movement and land use to land surface temperature can be formulated as follows, LST = 25.2 + 0.03X1 + 0.065X2 + 0.000093X3 - 0.001340X4 - 0.000091X5 - 0.000702X6. The increasing of of population movement (X1), industrial area (X2) and residential area (X3) will affect to increase the land surface temperature. Meanwhile, vacant land (X4), vegetated land (X5), and water bodies (X6) contribute to lowering air temperature. It means the air temperature in the city of Semarang become hotter in the future if the government doesn’t provide an enough open space as an instrument to reduce the increasing of air temperature.
The Impact of The Land-Use Changes on The Water Carrying Capacity in Kajen, Indonesia: A Spatial Analysis
Authors: Pugara A. , Pradana B. , Puspasari D. A. 
Published: November 2021

Abstract
Kajen Sub-District is the Capital of the Pekalongan Regency. This area is the center of activity that grows to be the urban area with trading and services as the economic pole. The trading and services activity is escalating inherent with the existence of IAIN and UNDIP campuses. The new campus increasing the need for a dormitory or housing and facilities area. Its result of land conversion in vegetation and agriculture. This spatial and development planning above contain in the Pekalongan Regency spatial document years 2020 – 2040. According to that document, the built-up area is predicted to be 50 % growth by the end of the planning period. The study regarding the influence of the land-use changes on the water carrying capacity in Kajen is conducted with the deductive–quantitative method. The deductive is begin to form theoretical synthesis about the themes and then search the empirical fact to compare. The quantitative approach means the data of the study is can be count rationally. The analysis tools of the study are spatial analysis and correlation. The study aims to examine the influence of the land-use change on the water carrying capacity and the most significant land use which influences it. The result of the study it the most influencing land use in water carrying capacity is a settlement with an 8.7-point level of correlation. The settlement appears from the agricultural land conversion, especially dry land and paddy field.
Quantification of Land Cover Changes in Sub-urban Areas of Pekanbaru City
Authors: Firmansyah F. , Raharja A. B. 
Published: November 2021

Abstract
Morphologically, land cover, urban and rural areas have different characteristics. It is the same as Pekanbaru City area that has unique characteristics including its surrounding regencies. However, the high level of land demand caused by increasing economic activity, high natural and non-natural population growth, makes the morphology of land cover in urban and rural areas unclear. Empirically this beginning to be considered common in urban areas that have a role as a strategic point or center of economic activity, but one of the concerns is the development of unplanned and dominating areas in a space that later create a more fragile environmental conditions in suburban areas. This study aimed to identify changes in land cover and assess the level of conformity of land use in the suburbs of Pekanbaru City. This study used a description method with two stages, (1). Identifying land cover using temporal images, (2). Analyze the level of conformity of land use. The results showed that there are four patterns of land cover change in the suburbs of Pekanbaru City, especially on the road axis connecting the surrounding area. These developments indicate nonconformity of land use which has an impact on the loss of protected land and productive plantation land in the suburbs of Pekanbaru City.
Mapping of Potential Village-Owned Enterprises (BUMDes) for Rural Economic Recovery during the COVID-19 Pandemic in Central Java, Indonesia
Authors: Sofianto A. , Risandewi T. 
Published: November 2021

Abstract
For several years the Government of Indonesia has been initiating the growth of Village-Owned Enterprises (BUMDes), economic institutions that manage the village’s economic resources. The Central Java Provincial Government also provides incentives to establish BUMDes in most villages in Central Java. During the COVID-19 pandemic, some rural communities were affected, and the village economy stagnated. BUMDes is one of the village economic institutions that is expected to be able to drive the village economy in the era of the COVID-19 pandemic. This study aims to analyze the potential of BUMDes as a solution to handling the impact of the COVID-19 pandemic in rural areas, especially from an economic aspect in Centra Java. This type of research is descriptive with the main qualitative approach assisted by quantitative (mixed method). The research technique used was a survey involving 337 villages. Respondents came from elements of village officials and BUMDes managers. The instrument used was through online media (google form). Data analysis used descriptive statistical techniques in the form of means and percentages. The conclusion of this study shows that BUMDes has the potential to play a role in economic recovery, but this function is not yet optimal. because the business sector managed by BUMDes is not based on the village’s superior potential, as well as the lack of a business development concept, weak human resource and capital capacity, and lack of cooperation.
Mapping of Re-Assessing Gentrification Process Post-Pandemic COVID-19 in The Old Town Semarang, Indonesia
Authors: Dewi S. P. , Susanti R. , Wungo G. L. 
Published: November 2021

Abstract
The revitalization of The Semarang Old Town revived this area as a tourist destination and generated regional economic growth. Several new restaurants, coffee shops, galleries, and other economic activities emerge along with tourism development. Job vacancies were offered and attracted newcomers to work as well as to invest. Consequently, properties that previously had no economic value became a potential asset, increasing land prices and building rental prices significantly. Hence, gentrification becomes an inevitable phenomenon. Local communities previously inhabited vacant buildings for years were displaced because the buildings would be restored and then rented out. However, these situations changed after the COVID-19 pandemic occurred, that many restrictions on community activities, including tourism. Visitors’ numbers decrease drastically, making many businesses in the Old Town suffer losses. It pointed by several coffee shops and restaurants closed, or they did not extend the rents. In contrast, the number of informal sectors which restricted surged in line with many work terminations. Hence, this study aims to re-assess the gentrification process along with the socio-economic changes after the COVID-19 pandemic. This study used a quantitative method by applying the spatial analysis method, which compares aspects such as physical transformation, space use, land prices, rent prices, land ownership, and population growth before and after the COVID-19 pandemic.
Mapping of Rural Health Services during Covid-19 Pandemic in Central Java, Indonesia: Rethinking Remoteness
Authors: Andini I. , Djunaedi A. 
Published: November 2021

AbstractCovidl9 pandemic, since 2019 in global world and 2020 in Indonesia, changed human daily life and affected the provision of public services, especially health services. As Covid19 spread through close interactions among humans, rural areas have the advantage of remoteness compared to higher-density urban areas. In the villages with relatively isolated access, the spread of Covid-19 is very low compared to the national average. This paper discusses how remoteness has become two sides of the coin during pandemic by examining at the data of health services in three rural areas in Provinsi Jawa Tengah, Indonesia. Data collected by in-depth interviews showed that although remoteness became a key factor in delaying the spread of Covid19, it also became a key factor in the deterioration of advanced health services in non-covid diseases throughout the pandemic. These findings confirmed the vulnerability of basic services in rural areas, even on Java Island as a center of growth in Indonesia. Using causal network analysis, the discussion revealed that the vulnerability stem from the territorial approach in health service provision making rural areas less resilient during pandemic. This paper concludes that while remoteness provides a barrier in retaining the spread of pandemic disease, it also worsens the medical treatment capacity in non-pandemic diseases in rural areas. Covid19 pandemic raises the need of specific arrangement public health services in remote rural areas.
The Use of Data and Information in Irrigation Water Management (Case Study: Colo Irrigation Area, Bengawan Solo River Basin)
Authors: Werdiningtyas R. , Suminar L. , Kusumastuti K. 
Published: November 2021

Abstract
In term of geography, water is a resource which is not favouring administrative boundaries. Water has its behaviour in flowing. However, we cannot confidently say that water flows following the laws of gravity. There is no guarantee that locations which are close to reservoir or water resource are not prone. Water scarcity when comparing the resource to demand for it is more relative than absolute. Irrigation water management is aimed to guarantee to make every agricultural land has access to water. In other hand, map is an important tool especially for portraying conditions of an area such as river basin. Map have played important roles in water management. This study aims to explore the use of data in decision making in irrigation water management practices. Colo irrigation area in Bengawan Solo river basin was chosen not only its vast coverage area but also because of its complexity in water management. It across two provinces and six municipalities. Content analysis was undertook to analyse two data sets: laws and regulation related to water management practice and the interview of policy actors. Elaborating the implementation of laws and regulations regarding to the use of data and information in irrigation water management, the comparison of the results also disclosed deviations among what it is regulated and what it is implemented. Quantitative and qualitative data that mostly used in practices cannot fully support to inform water conditions, physical and environmental conditions, social economic conditions in wider context. Spatial data is essential tools to represent comprehensive interconnected data and information in wider context. A profound understanding of stakeholder perspectives on the role of each data and information is essential for policy actors in the implementation of integration water resource management. Shared, comprehensive and interconnected data can promote common ground and collaboration potential.
First passage dynamics of stochastic motion in heterogeneous media driven by correlated white Gaussian and coloured non-Gaussian noises
Authors: Mutothya Nicholas Mwilu , Xu Yong , Li Yongge , Metzler Ralf , Mutua Nicholas Muthama 
Published: November 2021

Abstract
We study the first passage dynamics for a diffusing particle experiencing a spatially varying diffusion coefficient while driven by correlated additive Gaussian white noise and multiplicative coloured non-Gaussian noise. We consider three functional forms for position dependence of the diffusion coefficient: power-law, exponential, and logarithmic. The coloured non-Gaussian noise is distributed according to Tsallis’ q-distribution. Tracks of the non-Markovian systems are numerically simulated by using the fourth-order Runge–Kutta algorithm and the first passage times (FPTs) are recorded. The FPT density is determined along with the mean FPT (MFPT). Effects of the noise intensity and self-correlation of the multiplicative noise, the intensity of the additive noise, the cross-correlation strength, and the non-extensivity parameter on the MFPT are discussed.