bluuebunny/crossref_metadata_2025_split huggingface dataset:
DeeReCT-TSS: A novel meta-learning-based method annotates TSS in multiple cell types based on DNA sequences and RNA-seq data
Authors: Zhou Juexiao , zhang bin , Li Haoyang , Zhou Longxi , Li Zhongxiao , Long Yongkang , Han Wenkai , Wang Mengran , Cui Huanhuan , Chen Wei , Gao Xin 
Published: June 2021

Abstract
The accurate annotation of transcription start sites (TSSs) and their usage is critical for the mechanistic understanding of gene regulation under different biological contexts. To fulfil this, on one hand, specific high-throughput experimental technologies have been developed to capture TSSs in a genome-wide manner. On the other hand, various computational tools have also been developed for in silico prediction of TSSs solely based on genomic sequences. Most of these computational tools cast the problem as a binary classification task on a balanced dataset and thus result in drastic false positive predictions when applied on the genome-scale. To address these issues, we present DeeReCT-TSS, a deep-learning-based method that is capable of TSSs identification across the whole genome based on both DNA sequences and conventional RNA-seq data. We show that by effectively incorporating these two sources of information, DeeReCT-TSS significantly outperforms other solely sequence-based methods on the precise annotation of TSSs used in different cell types. Furthermore, we develop a meta-learning-based extension for simultaneous transcription start site (TSS) annotation on 10 cell types, which enables the identification of cell-type-specific TSS. Finally, we demonstrate the high precision of DeeReCT-TSS on two independent datasets from the ENCODE project by correlating our predicted TSSs with experimentally defined TSS chromatin states. Our application, pre-trained models and data are available at https://github.com/JoshuaChou2018/DeeReCT-TSS_release.
Replica Exchange Molecular Dynamics Simulations Reveal Self-association Sites in M- Crystallin Caused by Mutations Provide Insights of Cataract
Authors: Patel Sunita , Hosur Ramakrishna V. 
Published: June 2021

Abstract
Crystallins are ubiquitous, however, prevalence is seen in eye lens. Eye lens crystallins are long-lived and structural intactness is required for maintaining lens transparency and protein solubility. Mutations in crystallin often lead to cataract. In this study, we performed mutations at specific sites of M-crystallin, a close homologue of eye lens crystallin and studied by employing replica exchange molecular dynamics with generalized Born solvation model. Mutations were made on the Ca2+ binding residues (K34D and S77D) and in the hydrophobic core (W45R) which is known to cause congenital cataract in homologous γD-crystallin. The chosen mutations caused large motion of the N-terminal Greek key, concomitantly break the interlocking Greek keys interactions and perturbed the compact core resulting in several folded and partially unfolded states. Partially unfolded states expose large hydrophobic patches that can act as precursors for self-aggregation. Accumulation of such aggregates is the potential cause of cataract in homologous crystallins.
Inter-basin water transfer
Authors: Kheirinejad Shima , Bozorg-Haddad Omid , Quanrud David 
Published: June 2021

Abstract
Providing water to satisfy human demands is one of the greatest challenges of the present century and has been the source of many changes in the world. Since the amount of renewable water the Earth receives is only equal to, or even less than, that received many years ago, renewable water per capita decreases as human population increases. Inter-basin water transfer is a method to augment supply in water-scarce regions.
Increasing demand for water in some areas sometimes justifies the transfer of water from one basin to another. Water consumption in densely populated cities and in large industrial and agricultural operations produces an economic value that justifies the cost of expensive water transport equipment and infrastructure such as transmission channels, pipelines, pumping stations and dams. Under these conditions, water that is not in high demand in one basin is transferred to another basin for use. These projects are supply-driven engineering solutions to major social challenges. Inter-basin water transmission is carried out across local, regional, national, and international boundaries to overcome water scarcity, to meet demand in the agricultural, industrial and domestic sectors as well as to achieve economic and social development.
Inter-basin transfer (IBT) is an important water resource management tool that can have significant impacts on the donor and recipient basins. This chapter aims to provide insights into the concepts, logics, methods and tools used to evaluate inter-basin transfer projects. Challenges that may arise with implementation of such projects and management methods to overcome these challenges are reviewed. Several case study examples of existing projects are presented to provide insight into how to better manage such projects in the future.
Land use planning and overseas production
Authors: Bozorg-Haddad Omid , Rajabi Mohammad-Reza , Loáiciga Hugo A. 
Published: June 2021

Abstract
Land use planning is defined as the regulation of the relationship between space and human activities. Space occupied by human settlements, farmland and forests, parks, fallow land, rivers and lakes, and by transportation networks constitutes a network of areas dedicated to land uses such as agriculture, forestry, rangeland, industry, mining, recreation, and fishing. Land use planning is a comprehensive and long-term approach to planning human relations and their activities in space; it is the task of regulating and coordinating the strategies and general orientations of sectors, and it is the foundation of economies and human activities. The purpose of land use planning is to achieve an optimal distribution of economic and social activities. Land use selection and management are commonly done without regard to the carrying capacity of the land which, when exceeded, results in economic losses and in a reduction of environmental quality. The overall goal of land use planning is to achieve the optimal use of the land within the national interest framework. Accordingly, formulating a successful plan for managing the development of a country requires proper attention to the roles of geography and land use. Creation of a suitable balance between the Earth and its use by human activities can be achieved by proper land management. The increasing importance of environmental issues and human alteration of natural environments calls for sustainable development and land use practices that conserve natural resources while benefiting society and the environment. Nowadays, due to many factors such as climate change, population growth, changing standards of living, poverty, access to education, and mismanagement of natural and water resources, there is a need to diversify food and agricultural production in a variety of ways. Overseas cultivation is one of them, and it has potential for improving agricultural production. The practice of overseas cultivation by a country means planting and harvesting of a variety of agricultural products in other countries to be sold in its domestic market or in foreign markets. There are five basic principles that underline the success of overseas cultivation involving any group of countries: (1) mutual respect for the governance of all countries; (2) making and abiding by agreements between the countries; (3) non-interference in the internal problems of each country and respect for the territorial integrity of all countries; (4) optimal use of human resources and capacities to support agricultural activities and trade; and (5) expanding security and military cooperation.
Impact of climate change on hydro-meteorological drought over the Be River Basin, Vietnam
Authors: Khoi Dao Nguyen , Sam Truong Thao , Loi Pham Thi , Hung Bui Viet , Nguyen Van Thinh 
Published: June 2021

Abstract
In this paper, the responses of hydro-meteorological drought to changing climate in the Be River Basin located in Southern Vietnam are investigated. Climate change scenarios for the study area were statistically downscaled using the Long Ashton Research Station Weather Generator tool, which incorporates climate projections from Coupled Model Intercomparison Project 5 (CMIP5) based on an ensemble of five general circulation models (Can-ESM2, CNRM-CM5, HadGEM2-AO, IPSL-CM5A-LR, and MPI-ESM-MR) under two Representative Concentration Pathway (RCP) scenarios (RCP4.5 and RCP8.5). The Soil and Water Assessment Tool model was employed to simulate streamflow for the baseline time period and three consecutive future 20-year periods of 2030s (2021–2040), 2050s (2041–2060), and 2070s (2061–2080). Based on the simulation results, the Standardized Precipitation Index and Standardized Discharge Index were estimated to evaluate the features of hydro-meteorological droughts. The hydrological drought has a 1-month lag time from the meteorological drought and the hydro-meteorological droughts have negative correlations with the El Niño Southern Oscillation and Pacific Decadal Oscillation. Under the climate change impacts, the trends of drought severity will decrease in the future; while the trends of drought frequency will increase in the near future period (2030s), but decrease in the following future periods (2050 and 2070s). The findings of this study can provide useful information for the policy- and decisionmakers for a better future planning and management of water resources in the study region.
Modelling and optimization of hexavalent chromium removal from aqueous solution by adsorption on low-cost agricultural waste biomass using response surface methodological approach
Authors: Rzig Boutheina , Guesmi Fatma , Sillanpää Mika , Hamrouni Béchir 
Published: June 2021

Abstract
In this study, a response surface methodology (RSM) approach using central composite design (CCD) was investigated to develop a mathematical model and to optimize the effects of pH, adsorbent amount and temperature related to the hexavalent chromium removal by biosorption on peanut shells (PSh). The highest removal percentage of 30.28% was found by the predicted model under the optimum conditions (pH of 2.11, 0.73 g of PSh and 37.2 °C) for a 100 mg/L initial Cr(VI) concentration, which was very near to the experimental value (29.92%). The PSh was characterized by SEM, EDX, FTIR, BET, XRD analyses. Moreover, a Langmuir isotherm fitted well (R2 = 0.992) with the experimental data, and the maximum adsorption capacity was discovered to be 2.48 and 3.49 mg/g respectively at 25 and 45 °C. Kinetic data were well foreseen by pseudo second order. Thermodynamic study depicted that biosorption of Cr(VI) onto PSh was spontaneous and endothermic. Regeneration of the PSh using NaOH showed a loss &lt;5% in the Cr(VI) removal efficiency up to three recycle runs. In summary, the Cr(VI) removal onto economic, sensitive and selective biosorbent (PSh) was optimized using CCD to study biosorption behaviors.
Newly Designed Decellularized Scaffolds for Scaffold-based Gene Therapy from Elastic Cartilages via Supercritical Carbon Dioxide Fluid and Alkaline/ Protease Treatments
Authors: Huang Ching-Cheng 
Published: June 2021

Background:
Scaffold-based gene therapy provides a promising approach for tissue engineering,
which was important and popular as it combined medical applications and engineering materials’
knowledge.

Objective:
The decellularization techniques were employed to remove the cellular components from
porcine elastic cartilages, leaving a native decellularized Extracellular Matrix (dECM) composition
and architecture integrity of largely insoluble collagen, elastin, and tightly bound glycosaminoglycans.
For newly designed collagen scaffold samples, elastic cartilages were hydrolyzed by protease with different
concentrations to gain state completely and clearly.

Methods:
An extraction process of Supercritical Carbon Dioxide (ScCO2) was used to remove cellular
components from porcine elastic cartilage. The dECM scaffolds with collagen must be characterized
by Fourier transform infrared spectroscopy(FTIR), Thermo-Gravimetric Analysis (TGA), and Scanning
Electron Microscope (SEM).

Results:
The study provided a new treatment combined with supercritical carbon dioxide and alkaline/
protease to prepare dECM scaffolds with hole-scaffold microstructures and introduce into a potential
application on osteochondral tissue engineering using scaffold-based gene therapy. The new
process is simple and efficient. The pore-scaffold microstructures were observed in dECM scaffolds
derived from porcine elastic cartilages. The Tdmax values of the resulting dECM scaffolds were observed
at over 330oC.

Conclusion:
A series of new scaffolds were successfully obtained from porcine tissue by using ScCO2
and alkaline/enzyme treatments such as a mixing aqueous solution of NH4OH and papain. The dECM
scaffolds with high thermal stability were obtained. The resulting scaffold with clean pore-scaffold
microstructure could be a potential application for scaffold-based gene therapy.
Smart Bus System for Automatic Ticket Collection and Passenger Information Display using IoT and RFID Technology
Authors: Amrutha Ms. 
Published: June 2021

Buses are an integral means of conveyance in India. In metropolitan cities like Mumbai, Bangalore, Chennai and Delhi, 10-15 million people travel through public transport buses daily. Today, within the era of Digital India (a campaign launched by the govt of India) and Cashless Economy, conveyance must adapt the technology advancement. Even though the general public transport buses are providing fairly satisfactory services, there's a requirement for smart and reliable system. The major problems experienced by the passengers are undue waiting time at bus stops, non-refund of balance, negligence to supply seat to other passengers, etc. Thus, to provide an agile and smooth ticketing experience, we have proposed the smart application that will automatically shows the seat to passenger and mode of payment will be cashless there by promoting digitalization and smart cities initiatives. The user can check the availability	of seats. Keyword: Cashless Economy, Public transport, RFID and IOTI.
Epidemiology of the socio-demographic profile of HIV-positive people in Varna after 2015
Authors: Kolarova-Dimitrova M. , Paunov T. 
Published: June 2021

Introduction. The epidemic process of HIV/АIDS is a complex mix of diverse epidemics in and between different countries and regions around the world and is a leading public health crisis of our time.Aim. The purpose of this study is to analyze the socio-demographic profile of HIV-positive people in Varna. after 2015.Materials and methods. This study included a total of 100 HIV-positive people. All statistical analyzes are performed using SPSS v. 20.0 software. Analysis of variancecomparative analysis (r2), correlation analysis (Student’s coefficient, r) and risk analysis (RR) were used. Level of significance was taken to be 0.05 and 95% confidence interval were calculated.Results. The results of the epidemiological analysis show that the Varna region is characterized by a low endemic risk of HIV / AIDS. The majority of PLHIV are men (72.0%), mainly among men who have sex with men (72.0%), persons aged 20–29 (56.00%) with secondary education (58.0%), вulgarian ethnicity (66.0%) and those living in the city (82.0%) predominate. About 1⁄3 (32.0%) of the subjects had sexually transmitted infections, with syphilis rankng first (43.80%) followed by hepatitis C (25.0%).Conclusion. The city of Varna is defined as a successful model in the field of HIV/АIDS prevention, based on risk groups characteristics, with excellent cooperation between the interested institutions, and a good strategic approach in the planning and development of local HIV/AIDS prevention policies.
Loving GOD, Loving Others: The Evil of Hatred by Accidental Differences in Humankind
Authors: PhD Michael A. Milton, 
Published: June 2021

The rise of ideologies in the West that promote prejudicial treatment of
others based on accidental (humanly uncontrollable) features
(distinguishing ethnic physical traits, geographic origin, physical or
mental capacities, or native cultures, viz., Western
Civilization, that in all of its vicissitudes, has produced distinctive
behavioral, socio-religious, and intellectual norms) is an illogical,
cruel, and nationally self-destructive worldview that must be exposed
and rejected. The premise of “races” of human beings (Caucasian race,
negroid race, mongoloid race, etc.) , rather than the “race of
Mankind,” male and female, all originating from a common set of
ancestors, created by God, with “in-species” genetic variety (e.g.,
melanin production creating darker or lighter skin color) is not only
unsupported by the teachings of the Old and New Testaments, but singled
out as sins against God. The author examines a recent case of a medical
doctor dreaming of murdering white people. The statement is considered
from both scientific and spiritual viewpoints. The author cites personal
experience in the United States military, as well as peer-reviewed
articles, to establish the hypothesis that the rise of violent tribalism
(“Balkanization”) produces Socialistic authoritarianism, which
forcibly reunites divided “tribes” under the flag of autocratic rule.
This opinion-editorial article concludes by asserting that the Gospel of
Jesus Christ is the powerful antidote that liberates people from this
pestilent consequences of original sin to discover authentic fraternity
in our common Imago Dei (the image of God in
Man), and transformative freedom from the effects of the Fall,
i.e., to embrace and be embraced by a divine love that transcends our
sin. Only in knowing such love can we be free from the hatred that
divides, the bitterness that excludes, and the pain and sorrow that
inevitably follows.
MANAJEMEN ASUHAN KEBIDANAN BAYI BARU LAHIR PADA BAYI NY “I” DENGAN BERAT BADAN LAHIR RENDAH (BBLR) DI RSUD SYEKH YUSUF KABUPATEN GOWA TANGGAL 23 JULI - 25 JULI 2019
Authors: Ismayanah Ismayanah , Nurfaizah Nurfaizah , Syatirah Syatirah 
Published: June 2021

Bayi dengan Berat Badan Lahir Rendah merupakan bayi yang lahir dengan berat badan kurang dari 2.500 gram tanpa memandang masa kehamilan, pada umumnya berat badan lahir rendah disebabkan karena adanya faktor dari ibunya yang mengalami penyakit tertentu, malnutrisi, faktor ekonomi maupun usia ibu yang melahirkan < 20 tahun atau >35 tahun.Karya tulis ilmiah ini bertujuan untuk Melaksanakan Manajemen Asuhan Bayi Baru Lahir Pada Bayi Ny “I” dengan Berat Badan Lahir Rendah di RSUD Syekh Yusuf Gowa menggunakan pendekatan dengan metode manajemen asuhan kebidanan tujuh langkah Varney dan SOAP dimulai dari bayi baru lahir.Hasil asuhan pada bayi Ny “I” dengan berat badan lahir rendah Asuhan dilakukan selama 6 hari perawatan baik di RS maupun di rumah adalah pengawasan nutrisi, penimbangan berat badan secara rutin, mempertahankan suhu dengan ketat, pencegahan infeksi, mengajarkan metode kanguru dan pijat bayi serta memberikan konseling mengenai penanganan bayi baru lahir.Kesimpulan dari studi kasus setelah perawatan menunjukkan bahwa hasil berat badan bayi bertambah dari berat badan sebelumnya (2200 gram) menjadi normal (2600 gram), tanda-tanda vital dalam batas normal dan telah dilakukan pengkajian. Pendokumentasian semua temuan dan tindakan yang telah dilaksanakan pada bayi ny “I” dengan hasil tidak ditemukannya kesenjangan antara teori dan kasus.
MANAJEMEN ASUHAN KEBIDANAN ANTENATAL PADA NY”R” USIA KEHAMILAN 30-34 MINGGU DENGAN ANEMIA RINGAN DI PUSKESMAS BONTOMARANNU GOWA TANGGAL 24 JULI-23 AGUSTUS 2019
Authors: Apriani Apriani , Firdayanti Firdayanti , Inayah Sari Jelita 
Published: June 2021

Pendahuluan Anemia merupakan suatu kondisi dimana kadar hemoglobin (HB) dalam darah kurang dari normal. Anemia pada kehamilan yaitu ibu hamil dengan kadar hemoglobin kurang dari 11 gr%. Hal ini dapat menyebabkan masalah kesehatan karena sel darah merah mengandung hemoglobin yang berfungsi membawa oksigen ke seluruh jaringan tubuh. Metode Tugas akhir ini untuk melakukan pendekatan Asuhan Kebidanan Antenatal pada Ny “R” Usia Kehamilan 30-34 Minggu dengan Anemia Ringan di Puskesmas Bontomarannu Gowa Tahun 2019 selama 4 Minggu dengan melakukan pendekatan manajemen asuhan kebidanan 7 langkah menurut Helen Varney dan pendokumentasian dalam bentuk SOAP. Hasil Asuhan yang diberikan pada Ny “R” dengan kasus Anemia Ringan yakni pemberian tablet tambah darah, konseling dan kunjungan rumah untuk pemantauan pola istirahat dan gizi makanan untuk mencegah terjadinya komplikasi baik pada ibu maupun janin, keadaan umum ibu baik, serta tidak terjadi komplikasi pada masa persalinan maupun pasca persalinan. Hasil yang di dapatkan dari kadar Hb 9,8 gr% menjadi 11 gr%. Kesimpulan dari studi kasus dengan manajemen asuhan 7 langkah Varney dan SOAP yakni dari kunjungan pertama sampai kunjungan keempat dengan hasil asuhan kehamilan berlangsung normal ditandai dengan pembesaran perut sesuai usia kehamilan, keadaan ibu dan janin baik, keluhan yang dirasakan ibu teratasi. Dari hasil pendokumentasian semua temuan dan tindakan yang telah dilaksanakan pada Ny “R” dengan hasil tidak ditemukan kesenjangan antara teori dan kasus.
Semi-T-maximal sumodules
Authors: Hadi Inaam M. A. , Elewi Alaa A. 
Published: June 2021

Let be a commutative ring with identity and be an -module. In this work, we present the concept of semi--maximal sumodule as a generalization of -maximal submodule.
We present that a submodule of an -module is a semi--maximal (sortly --max) submodule if is a semisimple -module (where is a submodule of ). We investegate some properties of these kinds of modules.
The “Gospel of Fatness” and Acts of Sitophobia: The Foodscape and Power Relations at the Grahamstown Lunatic Asylum, 1890 to circa 1910
Authors: Du Plessis Rory 
Published: June 2021

The article explores the foodscape of the Grahamstown Lunatic Asylum, South Africa, from 1890 to circa 1910. The staff of the asylum were disciples of the “gospel of fatness” in which a patient’s weight gain was regarded as an index of restored physical health and possibly also the onset of convalescence from mental illness. Nevertheless, the practice of this gospel at the asylum did not amount to an equitable distribution of food. Instead, the diet scale that the patients received was based on their race, sex and status as paying or non-paying patients. Although the patients were able to secure more food rations via sanctioned and illicit foodways, it is of significance that some patients sought to resist the regimen of the asylum and its dietary scale by acts of sitophobia – the refusal to eat. The study concludes by investigating the themes presented in the acts of sitophobia committed by women.
Western “Supremacy” and the “Renaissance” Issue: Decolonising as Imitative Reaction
Authors: Venter Ponti 
Published: June 2021

Claude Levi-Strauss reminds us that “the notion of humanity, encompassing, without distinction of race or civilization, all forms of the human species, is a recent phenomenon and of limited expansion … But for the major part of the human species, dozens of millennia, this notion appears totally absent. Humanity stops at the frontiers of the tribe, the language group, often even of the village …” (Finkielkraut 1996, 1).
Article Title: “Corporate Entrepreneurship in the Public Sector – a Case Study of the South African Revenue Service as a Government Agency”
Authors: Benyera Everisto 
Published: June 2021

Politeia 35 (2) 2016: 21–51, #2368
https://doi.org/10.25159/0256-8845/2368
When this article was originally published, the first author’s details were omitted.
The author details on the article have now been corrected to read as follows:

Aidan Connolly
University of Pretoria
aidanconnolly72@gmail.com

Jurie van Vuuren
University of Pretoria
Jurie.vanVuuren@up.ac.za