bluuebunny/crossref_metadata_2025_split huggingface dataset:
The HDPE composites reinforced with waste hybrid PET/cotton fibers modified with the synthesized modifier
Authors: Cao Wei , Li Qiuying , Wu Chifei 
Published: December 2021

Abstract
Large amounts of textile waste are generated every year and disposed of through landfill or incineration, leading to numerous environmental and social issues. In this study, waste hybrid polyethylene terephthalate (PET)/cotton fibers were used directly to reinforce high density polyethylene (HDPE) to prepare composites. In order to give full play to the fiber’s reinforcing characteristics, the PET/cotton fibers were further modified with the modifier using a novel synthesized tetraethyl orthosilicate/3-aminopropyl triethoxysilane (KH550)/polyethylene (PE)-g-MAH (MPE) hybrid (TMPE). Fourier transform infrared and scanning electron microscopy (SEM) confirmed that the TMPE was successfully coated on the surface of fibers. Furthermore, compared with the original and the MPE-modified fibers, the thermal stability of TMPE-modified fibers was significantly increased. SEM and mechanical test indicated that the compatibility of the modified fibers with HDPE had been significantly improved, which led to the improvement of mechanical properties. Compared with the original and MPE-modified fibers-reinforced HDPE composites, the bending strength, bending modulus, and impact strength of TMPE-modified fiber-reinforced HDPE composites were improved obviously by 31.7%, 25.7%, and 89.1%, respectively.
Non-Oscillating solutions of a generalized system of ODEs with derivative terms
Authors: Bharadwaj B V K , Baruah Pallav Kumar 
Published: December 2021

Abstract
We consider a system of ODEs of mixed order with derivative terms appearing in the non-linear function and show the existence of a solution which does not oscillate for such system. We applied the fixed point technique to show that under certain conditions there exists at least one solution to the system which is not only non-oscillating, but also asymptotically constant.
Different Paths of Neolithisation of the North-Eastern Part of Central Europe
Authors: Nowak Marek 
Published: December 2021

AbstractOrigins of the Neolithic in the north-eastern part of Central Europe were associated with migrations of groups of the Linear Pottery culture after the mid-sixth millennium BC, as in other parts of Central Europe. During these migrations, a careful selection of settlement regions took place, in terms of the ecological conditions most favourable for agriculture. The enclave-like pattern of the Neolithic settlement persisted into the fifth millennium BC when these enclaves were inhabited by post-Linear groups. The remaining areas, inhabited by hunter-gatherers, were not subject to direct Neolithisation. However, there are some indications of contact between farmers and hunter-gatherers. This situation changed from c. 4000 BC onwards because of the formation and spectacular territorial expansion of the Funnel Beaker culture (TRB). This archaeological unit for the first time covered in a relatively compact way the territory under consideration. The human substratum of this process consisted of both hunter-gatherers and farmers. Consequently, one can discourse about Neolithisation as such only in the former case. Not all Late Mesolithic hunter-gatherers accepted TRB patterns. Those communities still successfully carried on traditional lifestyle, gradually supplementing it with pottery (para-Neolithic). Their Neolithisation ended perhaps only in the first half of the second millennium BC.
Toward Ubimus Philosophical Frameworks
Authors: Keller Damián , Aliel Luzilei , Filho Marcos Célio , Costalonga Leandro 
Published: December 2021

AbstractWe tackle the philosophical implications of post-2020 music practices. To situate our discussion, we address pending issues in current definitions of music-making. Our analysis indicates that post-2020 definitions of music should feature sonic information and events, framed through social interactions and through the material grounding of the musical activity. Ubiquitous music (ubimus) furnishes a promising playing field for the emerging aspects of creative music-thinking. New frameworks that encompass the dynamic, multimodal and situated characteristics of music while skewing an anthropocentric perspective on creativity may provide meaningful targets for ubimus research toward a new notion of musicality. Three artistic projects serve to exemplify key aspects of this proposal: Atravessamentos, Memory Tree and Lyapunov Time. We address the philosophical implications of these artistic endeavors toward the construction of ubimus philosophical frameworks.
Ferroptosis-associated gene SLC7A11 is upregulated in NSCLC and correlated with patient’s poor prognosis: An integrated bioinformatics analysis
Authors: Huang He , Liu Juan , Wu Haiyan , Liu Fang , Zhou Xiaoxi 
Published: December 2021

Abstract

Objective
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC).

Material/methods
Ferroptosis inhibiting gene solute carrier family 7 member 11 (SLC7A11) mRNA expression was investigated in the database of TCGA and Oncomine and compared between the cancer tissue and the normal corresponding tissue of NSCLC patients. SLC7A11 gene mutation of NSCLC was investigated in the TCGA database by the online data analysis tool of Catalog of Somatic Mutations in Cancer (COSMIC) and cBioPortal. The protein–protein interaction (PPI) network of SLC7A11 and associated genes were constructed with the STRING database. Gene ontology (GO) and the KEGG pathway of genes involved in the PPI network were explored and demonstrated by a bubble plot. Progression-free survival (PFS), overall survival (OS) and postprogression survival (PPS) between SLC7A11high and SLC7A11low expression groups were compared and demonstrated by the survival curve.

Results
SLC7A11 mRNA was upregulated in cancer tissues compared to paired normal tissues in colorectal adenocarcinoma, esophageal squamous cell carcinoma, lung squamous cell carcinoma rectum adenocarcinoma and uterine corpus endometrial carcinoma. Missense and synonymous substitutions were 66.67% and 16.67% for lung squamous cell carcinoma. For lung adenocarcinoma, the missense and synonymous substitutions were 66.67% and 33.33% respectively. In the case of single nucleotide mutation, A>T, C>G, G>A, G>T for lung squamous cell carcinoma and G>T, C>A, G>A, T> for lung adenocarcinoma were the most common mutations in the SLC7A11 coding strand. Fifty-one genes were included in the PPI network with an edge number of 287, average node degree of 11.3 and local clustering coefficient of 0.694, which demonstrated that the PPI network was enriched significantly (p = 1.0 × 10−16). In terms of the KEGG pathway, the SLC7A11 and PPI-involved genes were mainly enriched in ferroptosis, NSCLC, pathways in cancer, tp53 signaling pathway, etc. The overall survival (OS) in the SLC7A11high group was significantly lower than those of SLC7A11low groups in NSCLC (HR = 1.15, 95% CI: 1.02–1.31, p = 0.027). However, the progression-free survival (PFS) (HR = 1.17, 95% CI: 0.97–1.42, p = 0.098) and postprogression survival (PPS) (HR = 1.00, 95% CI: 0.78–1.29, p = 0.97) between SLC7A11high and SLC7A11low expression groups were not statistically different.

Conclusion
SLC7A11 was upregulated in NSCLC and correlated with the patient’s poor overall survival. SLC7A11 may be a potential target for NSCLC treatment through the ferroptosis pathway.
The Relationship Between Initial Tender and Mini-Competition: EU and Lithuanian Perspectives on Framework Agreements
Authors: Andhov Marta , Soloveičik Deividas 
Published: December 2021

The article conducts a comprehensive scholarly analysis of framework agreements – a public procurement technique often used across different European jurisdictions. Besides examining the general legal framework of the EU and Lithuanian law on framework agreements, the article also examines the newest EU case law. The authors analyse the relationship between the initial tender procedure establishing the framework agreement and the subsequent mini-competition that follows under the former to award the public contract. In contrast to the Lithuanian legal regulation and related case law, the authors argue that these two stages are interconnected and must be viewed as a unified part of the same procurement process in line with European legal doctrine. Finally, the article highlights the differences between framework agreements and public contracts.
Математичне моделювання екологічного стану природних об'єктів навколишнього середовища
Authors: Каленчук-Порханова Анжеліна Олексіївна , Тульчинський Вадим Григорович 
Published: December 2021

Статтю присвячено фундаментальним і прикладним напрямам робіт Інституту кібернетики ім. В.М. Глушкова НАН України, пов'язаним з вирішенням проблем аналізу ризиків виникнення надзвичайних ситуацій, забезпечення безпеки функціонування екологічних систем, дослідженням та прогнозуванням складних динамічних процесів у неоднорідних середовищах, розробленням методів математичного моделювання і комплексів їх чисельної реалізації, створенням високонадійних систем захисту інформації та автоматизованих систем математичного моделювання станів об'єктів навколишнього середовища. Наявність в Інституті кібернетики фахівців високої кваліфікації та потужного обчислювального ресурсу дозволяє гарантувати достовірність результатів при вирішенні складних наукових проблем. У статті також згадуються деякі пов'язані з Чорнобильською катастрофою події, які мають безпосередній зв'язок з обговорюваними напрямами робіт.
Radiation Exposure of Premature Infants Beyond the Perinatal Period
Authors: Hogan Alexander H. , Bellin Eran , Douglas Lindsey , Levin Terry L. , Esteban-Cruciani Nora 
Published: December 2021

OBJECTIVES:To determine the odds of premature compared with term infants exceeding the recommended radiation exposure threshold in the first year after discharge from birth hospitalization.METHODS:In this observational retrospective cohort study, we compared the radiation exposure of premature and term infants between 2008 and 2015 in an urban hospital system. The primary outcome was crossing the radiation exposure threshold of 1 millisievert. We assessed prematurity’s effect on this outcome with multivariable logistic regression.RESULTS:In our study, 20 049 term and 2047 preterm infants met inclusion criteria. The population was approximately one-half female, predominantly multiracial or people of color (40% African American and 44% multiracial), and of low socioeconomic status. Premature infants had 2.25 times greater odds of crossing the threshold compared with term infants after adjustment for demographics (95% confidence interval [CI]: 1.66–3.05). Adjustment for complex chronic conditions, which are validated metrics of pediatric chronic illness, attenuated this association; however, premature infants still had 1.58 times greater odds of crossing the threshold (95% CI: 1.16–2.15). When the final model was analyzed by degree of prematurity, very preterm and extremely preterm infants were significantly more likely to cross the threshold (1.85 [95% CI: 1.03–3.32] and 2.53 [95% CI: 1.53–4.21], respectively), whereas late preterm infants were not (1.14 [95% CI: 0.73–1.78]).CONCLUSIONS:Premature infants crossed the recommended radiation threshold more often than term infants in the year after discharge from birth hospitalization.
Standardizing Pediatric Somatic Symptom and Related Disorders Care: Clinical Pathway Reduces Health Care Cost and Use
Authors: Kullgren Kristin A. , Klein Edwin J. , Sturza Julie , Hutton David , Monroe Kimberly , Pardon Alicia , Sroufe Nicole , Malas Nasuh 
Published: December 2021

BACKGROUND:
Pediatric somatic symptom and related disorders (SSRDs) are common with high health care costs and use because of lack of standardized, evidence-based practice. Our hospital implemented a clinical pathway (CP) for SSRD evaluation and management. Our study objective was to evaluate health care cost and use associated with the organization’s SSRD CP in the emergency department (ED) and inpatient settings hypothesizing lower cost and use in the CP group relative to controls.

METHODS:
We conducted a retrospective analysis of costs and use before and after implementation of the SSRD CP. Data were collected from the hospital’s electronic health record and the Pediatric Health Information System database. Participants included pediatric patients on the CP (“P” group) and control groups with an SSRD diagnosis and mental health consultation either the year before the CP (“C” group) or during the CP study period (“T” group). Primary outcomes included costs, length of stay, diagnostic testing, imaging, subspecialty consultation, and readmission rates.

RESULTS:
The ED P group had more lower-cost imaging, whereas the inpatient T group greater higher-cost imaging than other groups. The inpatient P group had significantly shorter length of stay, fewer subspecialty consults, and lower costs. There were no significant group differences in readmission rates. The CP reduced median total costs per patient encounter by $51 433 for the inpatient group and $6075 for the ED group.

CONCLUSIONS:
The CP group showed significant reductions in health care cost and use after implementation of a CP for SSRD care. In future work, researchers should explore patient and practitioner experience with the SSRD CP and long-term outcomes.
Improving Youth Suicide Risk Screening and Assessment in a Pediatric Hospital Setting by Using The Joint Commission Guidelines
Authors: Latif Finza , Patel Shilpa , Badolato Gia , McKinley Kenneth , Chan-Salcedo Clarissa , Bannerman Reginald , Schultz Theresa Ryan , Newton Jacqueline , Schott Meghan Marie , Tyson Colby M. , Wavra Theresa , Robb Adelaide S. 
Published: December 2021

OBJECTIVES:Hospitals accredited by The Joint Commission (TJC) are now required to use a validated screening tool and a standardized method for assessment of suicide risk in all behavioral health patients. Our aims for this study were (1) to implement a TJC-compliant process of suicide risk screening and assessment in the pediatric emergency department (ED) and outpatient behavioral health clinic in a large tertiary care children’s hospital, (2) to describe characteristics of this population related to suicide risk, and (3) to report the impact of this new process on ED length of stay (LOS).METHODS:A workflow using the Columbia Suicide Severity Rating Scale was developed and implemented. Monthly reviews of compliance with screening and assessment were conducted. Descriptive statistics were used to define the study population, and multivariable regression was used to model factors associated with high suicide risk and discharge from the ED. ED LOS of behavioral health patients was compared before and after implementation.RESULTS:Average compliance rates for screening was 83% in the ED and 65% in the outpatient clinics. Compliance with standardized assessments in the ED went from 0% before implementation to 88% after implementation. The analysis revealed that 72% of behavioral health patients in the ED and 18% of patients in behavioral health outpatient clinics had a positive suicide risk. ED LOS did not increase. The majority of patients screening at risk was discharged from the hospital after assessment.CONCLUSIONS:A TJC-compliant process for suicide risk screening and assessment was implemented in the ED and outpatient behavioral health clinic for behavioral health patients without increasing ED LOS.
SOME PEDIATRICIANS' VIEWS CONCERNING PROBLEMS OF HANDICAPPED CHILDREN
Authors: MCPEAK WILLIAM 
Published: December 2021

MANY obstacles must be overcome before the health agencies and professions can successfully rehabilitate handicapped persons or adequately protect others from similar disablement, according to outstanding American pediatricians.
A survey of pediatricians' attitudes toward physical and mental crippling, recently completed by the Association for the Aid of Crippled Children, New York City, revealed a universal awareness that many important needs of the handicapped are still unmet and a determination that greater, more imaginative efforts must be made to meet them.
The biggest obstacle to full relief for the handicapped, as viewed by many survey respondents, is the lack of basic scientific knowledge concerning the cause of their diseases. Another obstacle of comparable seriousness is the lagging dissemination, among practicing physicians and other health workers who treat the handicapped, of the scientific knowledge which does exist and of the latest developments in techniques.
Although pediatricians realize that serious shortages exist in health facilities, personnel and other resources for direct care and treatment of handicapped individuals, they show relatively greater concern over deficiencies in the relevant knowledge and ineffectiveness of the technics now available. One reason for this view lies in the feeling that some diseases—for example, cerebral palsy—can never be treated with full success, once they exist; and that the necessary alternative is to prevent onset by further study of their causes.
New Concepts of the Etiology, Diagnosis, and Treatment of Congenital Megacolon (Hirschsprung's Disease), by Orvar Swenson, MD, et al,Pediatrics, 1949;4:201–209
Authors: Fitzgerald Joseph F. 
Published: December 2021

The clinical syndrome known as Hirschsprung disease (HD), or congenital megacolon, had been recognized for more than a century. The pathogenesis of the dilation/hypertrophy of the colon without mechanical obstruction was puzzling, and the subject of great debate. Virtually all infants and children affected with this disorder died.The authors studied 26 patients with congenital megacolon admitted to Boston Children's Hospital during a 5-year period, from 1943 through 1947. Careful contrast radiographic study of the distal colon in all 26 revealed a functional obstruction produced by a dyskinesia of the rectum. This was detected by running a small amount of barium slowly into the rectum with the patient in an oblique position. A portion of the rectum/rectosigmoid was consistently subnormal in caliber. Barium then was allowed to run through this narrowed area into the dilated colon. The authors interpreted the radiographic findings as evidence of a physiologic partial obstruction of the rectum/rectosigmoid.Colostomies were performed in the dilated portion of the colon in 3 early patients, and all symptoms/signs of HD disappeared in each instance. These returned, however, with closure of the colostomies and persisted until the ostomy was reestablished. Colostomies then were performed in an additional 12 patients, and each was relieved of symptoms with restoration of a normal-caliber colon. The authors recognized that the distal obstructing segment would have to be removed before the colostomy could be closed.They devised a special “pull-through” form of resection and tested it in the laboratory. The operation was performed subsequently on 23 patients, with no fatalities. Closure of the colostomy was possible in all but 2. The authors outlined the operation in detail in the article. Three infants, the youngest being 2 months old, tolerated a one-stage operation. The authors indicated that all patients subsequently demonstrated the urge to defecate and had normal bowel control.Patients with HD have a physiologic obstruction in the nondilated segment of colon. Early colostomy relieves the symptoms/signs of obstruction, and removal of the narrowed segment results in cure.
The Maintenance Need for Water in Parenteral Fluid Therapy, by Malcolm A. Holliday, MD, and William E. Segar, MD,Pediatrics, 1957;19:823–832
Authors: Chesney Russell W. 
Published: December 2021

One of the major objectives of parenteral fluid therapy is provision of water to meet physiologic losses. These losses, the insensible and urinary losses, have been extensively studied and defined for infants and adults. It is established from these studies that both insensible loss of water and urinary water loss roughly parallel energy metabolism and do not parallel body mass (weight). Therefore, any values that are applicable to all ages must be derived from some function of energy metabolism.Initially, and to a large extent even today, needs for water have been determined on the basis of weight in infants and on the basis of total amounts in adults. Although this serves well for infants and adults, the hapless individual between these two groups receives, at best, a rough estimate of his requirement for water.Crawford and his associates have referred needs for water, and a variety of drug dosages as well, to a unit of surface area (SA) because SA closely parallels basal energy metabolism. In this system SA is computed from a height-weight nomogram.It is generally agreed that the maintenance requirements for water of individuals is determined by their caloric expenditure. By means of the following formulae, the caloric expenditure of hospitalized patients can be determined from weight alone. For weights ranging from 0 to 10 kg, the caloric expenditure is 100 cal/kg/day; for weights ranging from 10 to 20 kg the caloric expenditure is 1000 cal plus 50 cal/kg for each kilogram of body weight &gt;10; for weight &gt;20 kg the caloric expenditure is 1500 cal plus 20 cal/kg for each kilogram &gt;20.Maintenance requirements for water depend on insensible loss of water and renal loss. An allowance of 50 mL/100 cal/day will replace insensible loss of water, and 66.7 mL/100 cal/day will replace renal losses. As water of oxidation will supply approximately 16.7 mL/100 cal/day, the remaining 100 mL/100 cal/day must be supplied to meet the remaining water losses of patients on parenteral fluid therapy. Possible exceptions to this figure are discussed.Maintenance requirements of sodium, chloride, and potassium are 3.0, 2.0, and 2.0 mEq/100/cal/day, respectively.
Aerosol Beclomethasone Dipropionate Compared With Theophylline as Primary Treatment of Chronic, Mild to Moderately Severe Asthma in Children, by David G. Tinkelman, MD, et al,Pediatrics, 1993;92:64–77
Authors: Furukawa Clifton T. 
Published: December 2021

Objective. To compare the benefits and adverse reactions of theophylline and beclomethasone (BDP) in the long-term control of mild to moderate chronic asthma in children.Design. Multicentered, double-blind, double-placebo, randomized, controlled trial.Patients. One hundred ninety-five children between the ages of 6 and 16 years with mild to moderate asthma.Intervention. Treatment with either BDP, 84 μg four times a day, or sustained-release theophylline administered twice daily I doses adjusted for optimum control of symptoms.Main Outcome Measures. Daily diary record of symptoms, peak flow rates, supplemental bronchodilator and glucocorticoid treatment, doctor and hospital visits, absence from work and school, and side effects.Results. Aerosol BDP and sustained-release theophylline were effective primary treatments for mild to moderate chronic asthma. BDP resulted in comparable symptom control with less bronchodilator use and fewer courses of systemic steroids than did theophylline. Side effects were observed significantly more frequently with theophylline than with BDP. Growth velocity suppression was noted with BDP and was more pronounced in boys. Suppression was not associated with alterations in cortisol measurements either at baseline or following stimulation.Conclusions. Both theophylline and BDP are effective therapy for mild to moderate asthma. Caution must be used with the administration of BDP in children because of possible growth velocity suppression.