bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis
Authors: Stazi Martina , Lehmann Sandra , Sakib M. Sadman , Pena-Centeno Tonatiuh , Büschgens Luca , Fischer Andre , Weggen Sascha , Wirths Oliver 
Published: December 2021

AbstractEpidemiological studies indicate that the consumption of caffeine, the most commonly ingested psychoactive substance found in coffee, tea or soft drinks, reduces the risk of developing Alzheimer’s disease (AD). Previous treatment studies with transgenic AD mouse models reported a reduced amyloid plaque load and an amelioration of behavioral deficits. It has been further shown that moderate doses of caffeine have the potential to attenuate the health burden in preclinical mouse models of a variety of brain disorders (reviewed in Cunha in J Neurochem 139:1019–1055, 2016). In the current study, we assessed whether long-term caffeine consumption affected hippocampal neuron loss and associated behavioral deficits in the Tg4-42 mouse model of AD. Treatment over a 4-month period reduced hippocampal neuron loss, rescued learning and memory deficits, and ameliorated impaired neurogenesis. Neuron-specific RNA sequencing analysis in the hippocampus revealed an altered expression profile distinguished by the up-regulation of genes linked to synaptic function and processes, and to neural progenitor proliferation. Treatment of 5xFAD mice, which develop prominent amyloid pathology, with the same paradigm also rescued behavioral deficits but did not affect extracellular amyloid-β (Aβ) levels or amyloid precursor protein (APP) processing. These findings challenge previous assumptions that caffeine is anti-amyloidogenic and indicate that the promotion of neurogenesis might play a role in its beneficial effects.
Membrane-bound IL-6R is upregulated on Th17 cells and inhibits Treg cell migration by regulating post-translational modification of VASP in autoimmune arthritis
Authors: Yan Shuaifeng , Golumba-Nagy Viktoria , Kotschenreuther Konstantin , Thiele Jan , Refaian Nasrin , Shuya Deng , Gloyer Lydia , Dittrich-Salamon Mara , Meyer Anja , Heindl Ludwig M. , Kofler David M. 
Published: December 2021

AbstractAutoimmune arthritis is characterized by impaired regulatory T (Treg) cell migration into inflamed joint tissue and by dysregulation of the balance between Treg cells and Th17 cells. Interleukin-6 (IL-6) is known to contribute to this dysregulation, but the molecular mechanisms behind impaired Treg cell migration remain largely unknown. In this study, we assessed dynamic changes in membrane-bound IL-6 receptor (IL6R) expression levels on Th17 cells by flow cytometry during the development of collagen-induced arthritis (CIA). In a next step, bioinformatics analysis based on proteomics was performed to evaluate potential pathways affected by altered IL-6R signaling in autoimmune arthritis. Our analysis shows that membrane-bound IL-6R is upregulated on Th17 cells and is inversely correlated with IL-6 serum levels in experimental autoimmune arthritis. Moreover, IL-6R expression is significantly increased on Th17 cells from untreated patients with rheumatoid arthritis (RA). Interestingly, CD4+T cells from CIA mice and RA patients show reduced phosphorylation of vasodilator-stimulated phosphoprotein (VASP). Bioinformatics analysis based on proteomics of CD4+T cells with low or high phosphorylation levels of VASP revealed that integrin signaling and related pathways are significantly enriched in cells with low phosphorylation of VASP. Specific inhibition of p-VASP reduces the migratory function of Treg cells but has no influence on effector CD4+T cells. Importantly, IL-6R blockade restores the phosphorylation level of VASP, thereby improving the migratory function of Treg cells from RA patients. Thus, our results establish a link between IL6R signaling and phosphorylation of VASP, which controls Treg cell migration in autoimmune arthritis.
The Vortex-like Behavior of the Riemann Zeta Function to the Right of the Critical Strip
Authors: Sepulcre J. M. , Vidal T. 
Published: December 2021

AbstractBased on an equivalence relation that was established recently on exponential sums, in this paper we study the class of functions that are equivalent to the Riemann zeta function in the half-plane $$\{s\in {\mathbb {C}}:\mathrm{Re}\, s>1\}$$

{
s
∈
C
:
Re

s
>
1
}

. In connection with this class of functions, we first determine the value of the maximum abscissa from which the images of any function in it cannot take a prefixed argument. The main result shows that each of these functions experiments a vortex-like behavior in the sense that the main argument of its images varies indefinitely near the vertical line $$\mathrm{Re}\, s=1$$

Re

s
=
1

. In particular, regarding the Riemann zeta function $$\zeta (s)$$

ζ
(
s
)

, for every $$\sigma _0>1$$

σ
0

>
1

we can assure the existence of a relatively dense set of real numbers $$\{t_m\}_{m\ge 1}$$

{

t
m

}

m
≥
1

such that the parametrized curve traced by the points $$(\mathrm{Re} (\zeta (\sigma +it_m)),\mathrm{Im}(\zeta (\sigma +it_m)))$$

(
Re

(
ζ

(
σ
+
i

t
m

)

)

,
Im

(
ζ

(
σ
+
i

t
m

)

)

)

, with $$\sigma \in (1,\sigma _0)$$

σ
∈
(
1
,

σ
0

)

, makes a prefixed finite number of turns around the origin.
Modelling the complexity of pandemic-related lifestyle quality change and mental health: an analysis of a nationally representative UK general population sample
Authors: Butter Sarah , Murphy Jamie , Hyland Philip , McBride Orla , Shevlin Mark , Hartman Todd K. , Bennett Kate , Gibson-Miller Jilly , Levita Liat , Martinez Anton P. , Mason Liam , McKay Ryan , Stocks Thomas V. A. , Vallières Frédérique , Bentall Richard P. 
Published: December 2021

Abstract
Purpose
The COVID-19 pandemic has affected the way many individuals go about their daily lives. This study attempted to model the complexity of change in lifestyle quality as a result of the COVID-19 pandemic and its context within the UK adult population.

Methods
Data from the COVID-19 Psychological Research Consortium Study (Wave 3, July 2020; N = 1166) were utilised. A measure of COVID-19-related lifestyle change captured how individuals’ lifestyle quality had been altered as a consequence of the pandemic. Exploratory factor analysis and latent profile analysis were used to identify distinct lifestyle quality change subgroups, while multinomial logistic regression analysis was employed to describe class membership.

Results
Five lifestyle dimensions, reflecting partner relationships, health, family and friend relations, personal and social activities, and work life, were identified by the EFA, and seven classes characterised by distinct patterns of change across these dimensions emerged from the LPA: (1) better overall (3.3%), (2) worse except partner relations (6.0%), (3) worse overall (2.5%), (4) better relationships (9.5%), (5) better except partner relations (4.3%), (6) no different (67.9%), and (7) worse partner relations only (6.5%). Predictor variables differentiated membership of classes. Notably, classes 3 and 7 were associated with poorer mental health (COVID-19 related PTSD and suicidal ideation).

Conclusions
Four months into the pandemic, most individuals’ lifestyle quality remained largely unaffected by the crisis. Concerningly however, a substantial minority (15%) experienced worsened lifestyles compared to before the pandemic. In particular, a pronounced deterioration in partner relations seemed to constitute the more severe pandemic-related lifestyle change.
Vascular Response on a Novel Fibrin-Based Coated Flow Diverter
Authors: Mühl-Benninghaus Ruben , Fries Frederik , Kießling Mara , Tomori Toshiki , Krajewski Stefanie , Simgen Andreas , Bauer Sabina , Hey Natascha , Brynda Eduard , Taborska Johanka , Riedel Tomáš , Reith Wolfgang , Cattaneo Giorgio , Brochhausen Christoph 
Published: December 2021

Abstract
Purpose
Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown to reduce material thrombogenicity and promote endothelial cell proliferation in vitro. We compared the biocompatibility of coated (Derivo Heal) and non-coated (Derivo bare) FDs with DAPT in an animal model.

Methods
Derivo® bare (n = 10) and Derivo® Heal (n = 10) FD were implanted in the common carotid arteries (CCAs) of New Zealand white rabbits. One additional FD, alternately a Derivo bare (n = 5) or Derivo Heal (n = 5), was implanted in the abdominal aorta (AA) for assessment of the patency of branch arteries. Histopathological examinations were performed after 28 days. Angiography was performed before and after FD implantation and at follow-up.

Results
Statistical analysis of the included specimens showed complete endothelialization of all FDs with no significant differences in neointima thickness between Derivo® bare and Derivo® Heal (CCA: p = 0.91; AA: p = 0.59). A significantly reduced number of macrophages in the vessel wall of the Derivo Heal was observed for the CCA (p = 0.02), and significantly reduced fibrin and platelet deposition on the surface of the Derivo Heal was observed for the AA. All branch arteries of the stented aorta remained patent.

Conclusion
In this animal model, the novel fibrin-based coated FD showed a similar blood and tissue compatibility as the non-coated FD.
Digital Literacy
Authors: Rolf Arno 
Published: December 2021

ZusammenfassungIn diesem Beitrag geht es nicht um fachspezifische Inhalte der Informatik. Um sie kümmern sich viele Lehrende in Forschung und Lehre und seit mehr als einem Jahr unter den erschwerten Bedingungen der Pandemie. Es geht um das Innovative der digitalen Transformation, um die Herausforderungen und Potenziale für Gesellschaft, Ökonomie und Umwelt und wie diese Teil der Informatiklehre werden können. Orientierung und Urteilsfähigkeit über den Prozess der digitalen Transformation zu erwerben, sollte im Zentrum von Digital Literacy stehen. Der Beitrag basiert auf Lehrerfahrungen aus mehreren Semestern, über die wir berichten werden.
Das Nationale Krebspräventionszentrum
Authors: Baumann Michael , Braun Anja , Helbig Ulrike , Nettekoven Gerd , Will Ursula 
Published: December 2021

Zusammenfassung
Hintergrund
Die Zahl der Krebserkrankungen wird sich in den nächsten Jahren deutlich erhöhen. Liegt die Zahl der Neuerkrankungen in Deutschland aktuell bei rund 500.000 pro Jahr, prognostizieren Experten für 2030 einen Anstieg um 20 % auf 600.000 Neuerkrankungen. Mit den zur Verfügung stehenden primärpräventiven Maßnahmen könnten schon heute rund 40 % aller Krebserkrankungen verhindert werden. Laut Schätzungen im europäischen Raum wäre über den gesamten translationalen Ansatz von Krebsforschung und onkologischer Versorgung einschließlich Ansätzen der Prävention ein krebsspezifisches 10-Jahres-Überleben von etwa 75 % im Jahr 2030 zu erreichen. Dennoch ist das Gesundheitswesen in Deutschland weit davon entfernt, dieses Potenzial voll auszuschöpfen – es fehlt an evidenzbasierten, kosteneffektiven und flächendeckenden Präventionsangeboten.

Schlussfolgerung
Ein systematischer Ausbau der angewandten Prävention und Präventionsforschung ist notwendig, um das Entstehen von Krebserkrankungen zu verhindern und den Anteil früh erkannter und mit heutigen Methoden heilbarer Krebserkrankungen messbar zu erhöhen. Hier setzt das im Herbst 2019 gemeinsam vom Deutschen Krebsforschungszentrum und der Deutschen Krebshilfe gegründete Nationale Krebspräventionszentrum an. Das Zentrum soll im Sinne eines Comprehensive Prevention Center hochrangige Präventionsforschung, Aus- und Weiterbildung sowie Öffentlichkeitsarbeit und Politikberatung direkt unter einem Dach vereinen und über Outreach-Programme und Netzwerkbildung flächendeckend implementieren. Dabei folgt es einer translationalen Strategie von der Grundlagenforschung bis hin zur Einführung neuer Methoden in evidenzbasierte flächendeckende Präventionssysteme.
Ethical Marketing in the Blockchain-Based Sharing Economy: Theoretical Integration and Guiding Insights
Authors: Tan Teck Ming , Salo Jari 
Published: December 2021

AbstractSince the introduction of Ethereum in 2015, blockchain technology (BT) has been evolving, and BT has been associated with the concept of the sharing economy by business academics. Despite the marketing research on the sharing economy that has been extensively conducted in the last decade, the linkage between BT and ethical marketing in the sharing economy remains unclear. Through a systematic literature review of 163 articles and a co-citation analysis, this study identifies the key elements of blockchain capabilities, blockchain attributes, and the underlying economic theories of blockchain. It also synthesizes and proposes a shift of ethical marketing logic in the blockchain-based sharing economy that delineates the principles of stakeholder capitalism. The article concludes with a list of future research directions that underline three approaches of stakeholder theory (i.e., the descriptive, instrument, and normative approaches). These directions aim to guide marketing scholars concerning how BT enables an institutionally embedded view of ethical marketing activities and practices that enhance collaborative marketing and subsequently innovate value chains and create sustainable business models in the sharing economy, as well as to the metaverse.
What About Us? Experiences of Relatives Regarding Physician-Assisted Death for Patients Suffering from Mental Illness: A Qualitative Study
Authors: Pronk Rosalie , Willems D. L. , van de Vathorst S. 
Published: December 2021

AbstractPhysician-assisted death (PAD) for patients suffering from mental illness is legally permitted in the Netherlands. Although patients’ relatives are not entrusted with a legal role, former research revealed that physicians take into account the patient’s social context and their well-being, in deciding whether or not to grant the request. However, these studies focussed on relatives’ experiences in the context of PAD concerning patients with somatic illness. To date, nothing is known on their experiences in the context of PAD concerning the mentally ill. We studied the experiences of relatives with regard to a PAD request by patients suffering from mental illness. The data for this study were collected through 12 interviews with relatives of patients who have or had a PAD request because of a mental illness. We show that relatives are ambivalent regarding the patient’s request for PAD and the following trajectory. Their ambivalence is characterised by their understanding of the wish to die and at the same time hoping that the patient would make another choice. Respondents’ experiences regarding the process of the PAD request varied, from positive (‘intimate’) to negative (‘extremely hard’). Some indicated that they wished to be more involved as they believe the road towards PAD should be a joint trajectory. To leave them out during such an important event is not only painful, but also harmful to the relative as it could potentially complicate their grieving process. Professional support during or after the PAD process was wanted by some, but not by all.
Delineation of molecular interactions of plant growth promoting bacteria induced β-1,3-glucanases and guanosine triphosphate ligand for antifungal response in rice: a molecular dynamics approach
Authors: Jha Yachana , Dehury Budheswar , Kumar S. P. Jeevan , Chaurasia Anurag , Singh Udai B. , Yadav Manoj Kumar , Angadi U. B. , Ranjan Rajiv , Tripathy Minaketan , Subramanian R. B. , Kumar Sunil , Simal-Gandara Jesus 
Published: December 2021

Abstract
Background
The plant growth is influenced by multiple interactions with biotic (microbial) and abiotic components in their surroundings. These microbial interactions have both positive and negative effects on plant. Plant growth promoting bacterial (PGPR) interaction could result in positive growth under normal as well as in stress conditions.

Methods
Here, we have screened two PGPR’s and determined their potential in induction of specific gene in host plant to overcome the adverse effect of biotic stress caused by Magnaporthe grisea, a fungal pathogen that cause blast in rice. We demonstrated the glucanase protein mode of action by performing comparative modeling and molecular docking of guanosine triphosphate (GTP) ligand with the protein. Besides, molecular dynamic simulations have been performed to understand the behavior of the glucanase-GTP complex.

Results
The results clearly showed that selected PGPR was better able to induce modification in host plant at morphological, biochemical, physiological and molecular level by activating the expression of β-1,3-glucanases gene in infected host plant. The docking results indicated that Tyr75, Arg256, Gly258, and Ser223 of glucanase formed four crucial hydrogen bonds with the GTP, while, only Val220 found to form hydrophobic contact with ligand.

Conclusions
The PGPR able to induce β-1,3-glucanases gene in host plant upon pathogenic interaction and β-1,3-glucanases form complex with GTP by hydrophilic interaction for induction of defense cascade for acquiring resistance against Magnaporthe grisea.

Graphical abstract
Student participation in university administration: factors, approaches and impact
Authors: Shahabul Haque , Muthanna Abdulghani , Sultana Monira 
Published: December 2021

AbstractWhat motivates students to participate in student organizations, how students participate in university administration decision-making, and how such participation influences students’ overall development is under-researched in Bangladesh. Therefore, to uncover such dynamics we employed document analyses, observations, and in-depth interviews with 25 university administrators, teachers, students, and social and cultural activists. As a result of this research, the findings reveal several factors behind students’ participation in student organizations that also participate in university administration. While such participation is positive for students’ overall development, the participation in university administration is not that effective. This requires of the university administration to reconsider students’ voices and interests while making decisions related to students’ overall development.
The sequence of manipulation matters: Abstract thinking offsets ego-depletion when induced before, but not after a depleting task
Authors: Unger Alexander , Papastamatelou Julie 
Published: December 2021

AbstractBased on theoretical and empirical studies dealing with the facilitation and inhibiting effects of different psychic distances (low vs. high construal-level), we tested if the exhibition of self-control under a high construal-level is a more efficient and less resource exhausting mode, compared to the exhibition of self-control under a low construal level. Prior studies already showed that the execution of self-control results in a lower construal-level and a high construal-level has facilitating effects on self-control. We expand upon these studies by: 1. operationalizing the whole process of ego-depletion through two sequential self-control tasks, 2. combining one ego-depletion and one construal-level manipulation in a 2 by 2 design and 3. varying the sequence of manipulations. In Experiment 1, we examined how the manipulation of the participants before and after being depleted, affects the self-control performance in a final task. In Experiment 2, we re-tested the offset of ego-depletion on another self-control measurement, with the condition of a high construal-level manipulated first. In Experiment 1 the ego-depletion effect remained existent when the construal-level was manipulated after the execution of self-control in a stroop test, but it was offset, when the construal-level was manipulated before the stoop test. Drawing on measurements of the perceived available self-control resources in Experiment 2, we were able to rule out an alternative approach, explaining similar results by an attentional shift towards reduced resources under low construal-level.
RhoGEF Trio Regulates Radial Migration of Projection Neurons via Its Distinct Domains
Authors: Wei Chengwen , Sun Mengwen , Sun Xiaoxuan , Meng Hu , Li Qiongwei , Gao Kai , Yue Weihua , Wang Lifang , Zhang Dai , Li Jun 
Published: December 2021

AbstractThe radial migration of cortical pyramidal neurons (PNs) during corticogenesis is necessary for establishing a multilayered cerebral cortex. Neuronal migration defects are considered a critical etiology of neurodevelopmental disorders, including autism spectrum disorders (ASDs), schizophrenia, epilepsy, and intellectual disability (ID). TRIO is a high-risk candidate gene for ASDs and ID. However, its role in embryonic radial migration and the etiology of ASDs and ID are not fully understood. In this study, we found that the in vivo conditional knockout or in utero knockout of Trio in excitatory precursors in the neocortex caused aberrant polarity and halted the migration of late-born PNs. Further investigation of the underlying mechanism revealed that the interaction of the Trio N-terminal SH3 domain with Myosin X mediated the adherence of migrating neurons to radial glial fibers through regulating the membrane location of neuronal cadherin (N-cadherin). Also, independent or synergistic overexpression of RAC1 and RHOA showed different phenotypic recoveries of the abnormal neuronal migration by affecting the morphological transition and/or the glial fiber-dependent locomotion. Taken together, our findings clarify a novel mechanism of Trio in regulating N-cadherin cell surface expression via the interaction of Myosin X with its N-terminal SH3 domain. These results suggest the vital roles of the guanine nucleotide exchange factor 1 (GEF1) and GEF2 domains in regulating radial migration by activating their Rho GTPase effectors in both distinct and cooperative manners, which might be associated with the abnormal phenotypes in neurodevelopmental disorders.
Characterization of the Geometric Distribution Via Linear Combinations of Observations and of Records
Authors: Arnold Barry C. , Villasenor Jose A. 
Published: December 2021

AbstractIn a sequence of independent identically distributed geometric random variables, the sum of the first two record values is distributed as a simple linear combination of geometric variables. It is verified that this distributional property characterizes the geometric distribution. A related characterization conjecture is also discussed. Related discussion in the context of weak records is also provided.