bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life in Patients With Systemic Lupus Erythematosus Ramathibodi Hospital
Authors: Kafaksom Thanuchporn , Dechapaphapitak Nichapha , Suangtamai Thanitta , Ngamjanyaporn Pintip , Pitidhammabhorn Dhanesh , Ruchakorn Nopparat 
Published: September 2021

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease. It is a chronic disease and exhibits symptoms in many organs and patients will be offered a variety of immunosuppressants, which may cause many side effects and worsen the quality of life.
Objective: To study the quality of life in SLE patients receiving treatment in Ramathibodi Hospital.
Methods: A cross-sectional study of all SLE patients were collected during February 2017 to February 2018, by using questionnaires to measure the quality of life.
Results: Total of 510 SLE patients, 96.7% were female. The mean (SD) age was 40.9 (13.0) years, and the disease duration was 10.5 (8.2) years. Most of them got a bachelor’s degree or higher (54.1%). Universal coverage scheme was the most treatment welfare of the patients. Despite the disease limitation for pregnancy, 7.2% of the SLE patients had 3 children while only 17.0% had miscarriages while pregnant. The general quality of life (SF-36) was in a good level, and disease-specific quality of life (SLEQoL) was at a moderate level. The older patients and a longer disease duration were inversely related to quality of life including physical health, overall health.
Conclusions: SLE patients who received the treatment at Ramathibodi Hospital had a relatively good quality of life. Factors related to quality of life were age and duration of the disease.
Muuttuva teollisuusmaisema
Authors: Juola Marjo 
Published: September 2021

Entisillä teollisuusalueilla jälleenrakennuspaineet kasvavat uusien kaavoitusten myötä. Tällainen uusiorakentaminen muuttaa olennaisesti sekä maisemaa-, että koko aluetta. Tässä pro gradu -tutkielmaani pohjautuvassa artikkelissa tarkastelen haastatteluiden, karttojen ja valokuvien avulla, miten muutos näkyy entisen Pateniemen sahan (1873–1990) alueella sahaustoiminnan päätyttyä. Pateniemen sahan kukoistuksen aikana alueen maisemaa hallitsivat laajalle levittyvät tapulitarhat. Sahan toiminnan loputtua vuonna 1990 tuotantorakennukset on purettu ja tapulitarhat ovat saaneet väistyä uusien asuinrakennusten tieltä. Maisema on kokenut dramaattisen muutoksen kasvavien rakennuspaineiden myötä, jollaiset usein odottavat Pateniemen sahan kaltaisia entisiä teollisuusalueita. Jäljellejääneiden sahaan liittyvien rakennusten käyttötarkoitukset ovat muuttuneet, mikä on osaltaan myös vaikuttanut alueen luonteeseen. Yhdistämällä kartta-aineistoa, valokuvia ja haastatteluaineistoa materiaalisiin jäännöksiin, analysoin alueen elinkaaren muutosta. Sahan ja sen myötä työ- ja harrastusmahdollisuuksien loppumisella on ollut suuri vaikutus sekä alueen asukkaisiin, joista suurin osa sai elantonsa sahalta, että alueen maisemaan, joka on muuttunut entisestä työläisten asuinalueesta merellisen Oulun uudisrakentamisen lippulaivaksi.
Prioritarianism in Health-Care: Resisting the Reduction to Utilitarianism
Authors: Reichlin Massimo 
Published: September 2021

Tännsjö’s book Setting Health-Care Priorities defends the view that there are three main normative theories in the domain of distributive justice, and that these theories are both highly plausible in themselves, and practically convergent in their normative conclusions. All three theories (utilitarianism, the maximin/leximin theory and egalitarianism) point to a somewhat radical departure from the present distribution of medical resources: in particular, they suggest redirecting resources from marginal life extension to the care of mentally ill patients. In this paper I wish to argue, firstly, that prioritarianism should not be considered as an amendment to utilitarianism, as it is in Tännsjö’s view, but as a distinctive fourth option. This can best be appreciated if we focus on a reading of the theory that emphasizes its derivation from egalitarianism and its attempt to develop an intermediate approach between utilitarian and egalitarian intuitions. Secondly, in response to Tännsjö’s central objection to prioritarianism, I will argue that the theory does not apply in intrapersonal cases but is only relevant for decisions regarding the interpersonal distribution of benefits. Finally, I will suggest that a practical convergence of the four theories on specific issues such as artificial reproduction or mood enhancement is far less likely than Tännsjö seems to believe.
Robust and Fast Lithium Storage Enabled by Polypyrrole-Coated Nitrogen and Phosphorus Co-Doped Hollow Carbon Nanospheres for Lithium-Ion Capacitors
Authors: Zhang Mengdi , Zheng Xuan , Mu Jiawei , Liu Pengfei , Yuan Wenhan , Li Shuli , Wang Xiaobo , Fang Haiqiu , Liu Haiyan , Xing Tao , Hu Han , Wu Mingbo 
Published: September 2021

Lithium-ion capacitors (LICs) have been proposed as an emerging technological innovation that integrates the advantages of lithium-ion batteries and supercapacitors. However, the high-power output of LICs still suffers from intractable challenges due to the sluggish reaction kinetics of battery-type anodes. Herein, polypyrrole-coated nitrogen and phosphorus co-doped hollow carbon nanospheres (NPHCS@PPy) were synthesized by a facile method and employed as anode materials for LICs. The unique hybrid architecture composed of porous hollow carbon nanospheres and PPy coating layer can expedite the mass/charge transport and enhance the structural stability during repetitive lithiation/delithiation process. The N and P dual doping plays a significant role on expanding the carbon layer spacing, enhancing electrode wettability, and increasing active sites for pseudocapacitive reactions. Benefiting from these merits, the NPHCS@PPy composite exhibits excellent lithium-storage performances including high rate capability and good cycling stability. Furthermore, a novel LIC device based on the NPHCS@PPy anode and the nitrogen-doped porous carbon cathode delivers a high energy density of 149 Wh kg−1 and a high power density of 22,500 W kg−1 as well as decent cycling stability with a capacity retention rate of 92% after 7,500 cycles. This work offers an applicable and alternative way for the development of high-performance LICs.
Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Stroke: A Systematic Review and Meta-Analysis
Authors: Li Wenxia , Hou Miaomiao , Ding Zhibin , Liu Xiaolei , Shao Yuan , Li Xinyi 
Published: September 2021

Background: Stroke has become a major problem around the world, which is one of the main causes of long-term disability. Therefore, it is important to seek a biomarker to predict the prognosis of patients with stroke. This meta-analysis aims to clarify the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the prognosis of stroke patients.Methods: This study was pre-registered in PROSPERO (CRD42020186544). We performed systematic research in PubMed, Web of Science, and EMBASE databases for studies investigating the prognostic value of NLR. Based on the enrolled studies, patients were divided into the low-NLR cohort and the high-NLR cohort. Odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and analyzed by the Review Manager 5.3 and Stata 12.0 software. Heterogeneity was estimated by using Cochran's Q test and I2 value. Sensitivity analyses and subgroup analyses were also performed to explore the potential sources of heterogeneity. Publication bias was assessed with funnel plots and assessed by Egger's tests.Results: Forty-one studies with 27,124 patients were included. In the overall analysis, elevated NLR was associated with an increased mortality in acute ischemic stroke (AIS) patients (OR = 1.12, 95% CI = 1.07–1.16) and in acute hemorrhagic stroke (AHS) patients (OR = 1.23, 95% CI = 1.09–1.39), poorer outcomes in AIS patients (OR = 1.29, 95% CI = 1.16–1.44), and in AHS patients (OR = 1.11, 95% CI = 1.03–1.20). While in terms of hemorrhagic transformation (HT), elevated NLR was associated with an increased incidence of HT in AIS patients (OR = 1.15, 95% CI = 1.08–1.23).Conclusions: This study demonstrated that elevated NLR was significantly associated with poor prognosis of stroke patients. High NLR is associated with a 1.1- to 1.3-fold increased risk of poor outcomes of AIS/AHS patients. NLR could be helpful as a potential prognostic biomarker to guide clinical decision making.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020186544.
Propofol-Based Total Intravenous Anesthesia is Associated with Better Survival than Desflurane Anesthesia in Epithelial Ovarian Cancer Surgery: A Retrospective Cohort Study
Authors: Tseng Wei-Cheng , Lee Meei-Shyuan , Lin Ying-Chih , Lai Hou-Chuan , Yu Mu-Hsien , Wu Ke-Li , Wu Zhi-Fu 
Published: September 2021

Background: Previous studies have shown that anesthetic techniques can affect outcomes of cancer surgery. We investigated the association between anesthetic techniques and patient outcomes after elective epithelial ovarian cancer surgery.Methods: This was a retrospective cohort study of patients who received elective open surgery for epithelial ovarian cancer between January 2009 and December 2014. Patients were grouped according to the administration of propofol or desflurane anesthesia. Kaplan–Meier analysis was performed, and survival curves were constructed from the date of surgery to death. Univariate and multivariate Cox regression models were used to compare hazard ratios for death after propensity matching. Subgroup analyses were performed for age, body mass index, preoperative carbohydrate antigen-125 level, International Federation of Gynecology and Obstetrics staging, and operation and anesthesia time.Results: In total, 165 patients (76 deaths, 46.1%) who received desflurane anesthesia and 119 (30 deaths, 25.2%) who received propofol anesthesia were eligible for analysis. After propensity matching, 104 patients were included in each group. In the matched analysis, patients who received propofol anesthesia had better survival with a hazard ratio of 0.52 (95% confidence interval, 0.33–0.81; p = 0.005). Subgroup analyses also showed significantly better survival with old age, high body mass index, elevated carbohydrate antigen-125 level, advanced International Federation of Gynecology and Obstetrics stage, and prolonged operation and anesthesia time in the matched propofol group. In addition, patients administered with propofol anesthesia had less postoperative recurrence and metastasis than those administered with desflurane anesthesia in the matched analysis.Conclusion: Propofol anesthesia was associated with better survival in patients who underwent elective epithelial ovarian cancer open surgery. Prospective studies are warranted to evaluate the effects of propofol anesthesia on oncological outcomes in patients with epithelial ovarian cancer.
Bifidobacterium Strains Present Distinct Effects on the Control of Alveolar Bone Loss in a Periodontitis Experimental Model
Authors: Shimabukuro Natali , Cataruci Amália C. de S. , Ishikawa Karin H. , Oliveira Bruna E. de , Kawamoto Dione , Ando-Suguimoto Ellen S. , Albuquerque-Souza Emmanuel , Nicoli Jacques R. , Ferreira Caroline M. , de Lima Jean , Bueno Manuela R. , da Silva Leandro B. R. , Silva Pedro H. F. , Messora Michel R. , Camara Niels O. S. , Simionato Maria Regina L. , Mayer Marcia P. A. 
Published: September 2021

Periodontitis is an inflammatory disease induced by a dysbiotic oral microbiome. Probiotics of the genus Bifidobacterium may restore the symbiotic microbiome and modulate the immune response, leading to periodontitis control. We evaluated the effect of two strains of Bifidobacterium able to inhibit Porphyromonas gingivalis interaction with host cells and biofilm formation, but with distinct immunomodulatory properties, in a mice periodontitis model. Experimental periodontitis (P+) was induced in C57Bl/6 mice by a microbial consortium of human oral organisms. B. bifidum 1622A [B+ (1622)] and B. breve 1101A [B+ (1101)] were orally inoculated for 45 days. Alveolar bone loss and inflammatory response in gingival tissues were determined. The microbial consortium induced alveolar bone loss in positive control (P + B-), as demonstrated by microtomography analysis, although P. gingivalis was undetected in oral biofilms at the end of the experimental period. TNF-α and IL-10 serum levels, and Treg and Th17 populations in gingiva of SHAM and P + B- groups did not differ. B. bifidum 1622A, but not B. breve 1101A, controlled bone destruction in P+ mice. B. breve 1101A upregulated transcription of Il-1β, Tnf-α, Tlr2, Tlr4, and Nlrp3 in P-B+(1101), which was attenuated by the microbial consortium [P + B+(1101)]. All treatments downregulated transcription of Il-17, although treatment with B. breve 1101A did not yield such low levels of transcripts as seen for the other groups. B. breve 1101A increased Th17 population in gingival tissues [P-B+ (1101) and P + B+ (1101)] compared to SHAM and P + B-. Administration of both bifidobacteria resulted in serum IL-10 decreased levels. Our data indicated that the beneficial effect of Bifidobacterium is not a common trait of this genus, since B. breve 1101A induced an inflammatory profile in gingival tissues and did not prevent alveolar bone loss. However, the properties of B. bifidum 1622A suggest its potential to control periodontitis.
Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men
Authors: Kyriakidou Yvoni , Cooper Isabella , Kraev Igor , Lange Sigrun , Elliott Bradley T. 
Published: September 2021

Background: Exercise-induced muscle damage (EIMD) results in transient muscle inflammation, strength loss, and muscle soreness and may cause subsequent exercise avoidance. Research has recently proven that skeletal muscle can also release extracellular vesicles (EVs) into the circulation following a bout of exercise. However, EV’s potential role, including as a biomarker, in the response to eccentric resistance exercise stimulus remains unclear.Methods: Twelve (younger, n=7, 27.0±1.5years and older, n=5, 63.0±1.0years) healthy, physically active males, undertaking moderate, regular physical activity (3–5 times per week) performed a unilateral high intensity eccentric exercise protocol. Venous plasma was collected for assessment of EVs and creatine kinase (CK) prior to EIMD, immediately after EIMD, and 1–72h post-EIMD, and maximal voluntary isometric contraction (MVIC) and delayed onset muscle soreness (DOMS) were assessed at all time points, except 1 and 2h post-EIMD.Results: A significant effect of both time (p=0.005) and group (p&lt;0.001) was noted for MVIC, with younger participants’ MVIC being higher throughout. Whilst a significant increase was observed in DOMS in the younger group (p=0.014) and in the older group (p=0.034) following EIMD, no significant differences were observed between groups. CK was not different between age groups but was altered following the EIMD (main effect of time p=0.026), with increased CK seen immediately post-, at 1 and 2h post-EIMD. EV count tended to be lower in older participants at rest, relative to younger participants (p=0.056), whilst EV modal size did not differ between younger and older participants pre-EIMD. EIMD did not substantially alter EV modal size or EV count in younger or older participants; however, the alteration in EV concentration (ΔCount) and EV modal size (ΔMode) between post-EIMD and pre-EIMD negatively associated with CK activity. No significant associations were noted between MVIC or DOMS and either ΔCount or ΔMode of EVs at any time point.Conclusion: These findings suggest that profile of EV release, immediately following exercise, may predict later CK release and play a role in the EIMD response. Exercise-induced EV release profiles may therefore serve as an indicator for subsequent muscle damage.
Quality of Life and Factors Affecting It: A Study Among People Living Near a Solid Waste Management Facility
Authors: Phan Long Thanh , Nguyen Gia Thanh , Nguyen Quynh Anh Dac , Nguyen Hieu Song , Nguyen Tin Trung , Watanabe Toru 
Published: September 2021

Background: The amount of waste generated has been increasing over the years. Meanwhile, the capacity of solid waste management facilities (SWMFs) for waste disposal does not meet the needs, resulting in adverse consequences on the natural environment and health of residents living near these plants, which can significantly degrade their quality of life (QoL). This study aims to evaluate the QoL of residents living near an SWMF and the potential impacts it has on the residents.Methods: A cross-sectional descriptive study was conducted involving 801 subjects, aged 18 and above, who live near the SWMF of Hue City, Vietnam. The QoL of the subjects was quantitatively assessed using the WHO QoL assessment scale (WHOQOL-BREF). The general, health, and environmental factors influencing QoL were identified using bivariate and multivariate logistic regression analyses.Results: About 22.6% of the subjects had a good QoL. In particular, the proportions for good psychological health (6.9%) and environment (13.6%) were low, indicating an influence of the SWMF. Significant factors that degraded the QoL of residents were less education defined by not graduating from high school (odds ratio, OR = 2.78; 95% CI = 1.09–7.06), poor health status (OR = 2.50; 95% CI: 1.56–4.01), dissatisfaction with water quality (OR = 2.41; 95% CI: 1.10–5.25), and unacceptance of the SWMF presence (OR = 1.70; 95% CI: 1.11–2.60). Moreover, subjects living within 2 km of the plant had dermatological diseases and digestive disorders more frequently than those who lived away from the plant. They also reported more complaints regarding water, air, and soil quality, which were likely due to the operation of the SWMF.Conclusions: Burying and disposing of solid waste at the SWMF might lead to the degradation of the surrounding water and soil environments, and its collection and transportation are considered to cause odor and dust. The efforts of responsible authorities to strictly supervise and inspect these activities at the SWMF are essential, not only to protect the surrounding environment but also to improve the QoL of those who live nearby these plants.
METHOD COMPONENT OF THE CULTURE-DEFENSE PEDAGOGICAL CONCEPT OF V. SCHEPOTIEV (1880–1937)
Authors: Grin Julia , Lobach Olena 
Published: September 2021

Method component of pedagogical conception of culture protection by V. Schepotiev – the first rector of Poltava folk education Institute, professor of Ukrainian literature and philology, art critic, ethnographer, archivist and artist – is partially observed. The aim of pedagogical concept of the scholar is in national culture of young generation forming by the means of Ukrainian culture, because this generation is responsible before the offspring and is to be capable to culture protection activity providing.The classification of methods given includes two groups: 1) Pedagogical (traditional and innovative); 2) Scientific (theoretical and research). Authors analyze verbal (lection, storytelling, explanation, conversation and dispute); visual (art samples, the examples of patents, pedagogues, famous artists and social leaders); practical (work with the textbooks, fiction and scientific-popular sources studying, written and creative works doing – exercises, review, critique, original works; work with fiction text – biographical, problem – thematical, cultural-historical methods, image and meaning analyses); stimulating (convincing, interesting, requirement, contest). Innovative methods of the first quarter of the XX century are: play, dramatization, «literature court». Modern teachers of humanitarian disciplines are recommended to use the method of «literature court», elaborated by V. Schepotiev, in their professional activity.
METHODOLOGICAL RESOURCES FOR UKRAINIAN LANGUAGE STUDY IN TODAY'S CANADA
Authors: Mashkova Inna 
Published: September 2021

The article analyzes modern state and development of methodological resources for Ukrainian language study in Canada nowdays. Cultural development of Ukrainian Canadians, their efforts in preserving their national identity became an example of success for other ethnic groups in North America primarily through education and the printed media, where broad and diversified activities of the Ukrainian community in Canada are reflected.The analysis of psychological and pedagogical, methodological, culture studies and other works of prominent Ukrainian educators in North-American periodicals of Ukrainian Diaspora proves a considerable role and significance of professional periodicals in forming professional competency of teachers.Efforts and attempts of Ukrainian-Canadian educationalists resulted in high quality Ukrainian-language learning programs (for example English-Ukrainian Bilingual Program – EUBP) and methodology that are due to the cooperation of talented scientific and practical educational staff applying new innovative technologies. Since national self-identification is realized through the native language (mother tongue) its learning and practical using by the Ukrainian community in Canada for more than 100 years was the very challenge but due to the Ukrainian Diaspora activities and federal government support it is in Canada where Ukrainian- language studies are realized in the most effective way. In a special educational environment in many Canadian provinces children have the chance “to thrive” in the public school system while extending their language capabilities and cultural awareness. As a result, the heritage language program promotes self-esteem of children and their parents, enhances personal and cultural identity, provides for better communication and problem-solving skills, expends cultural, economic and professional opportunities preparing them for living and working in cross-cultural environments.The author considers schooling to be an important factor of Ukrainian diaspora self-identification and activities in Canada that promotes forming and maintaining national identity of new generations of Ukrainians abroad as an integral part of active Ukrainians worldwide and emphasizes the prospectives of the positive experience of multicultural education in Canada and their implementation into policultural nations' education systems.