bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on tri-imidazole derivatives modified with triazine-trione structure as latent curing agents for epoxy resin
Authors: Wan Xiaodong , Liu Jianben , Chen Xi , Wang Jun 
Published: December 2021

AbstractIn this paper, four novel kinds of triazine-trione based tri-imidazole derivatives (IM-TT, 2MI-TT, 2EI-TT and EMI-TT) were synthesized through the addition reaction between triglycidyl isocyanurate (TGIC) and imidazole (IM), 2-methylimidazole (2MI), 2-ethylimidazole (2EI) and 2-ethyl-4-methylimidazole (EMI), respectively. The triazine-trione based tri-imidazole derivatives were blended with epoxy resin and the reactivity, thermal latency and thermal property were investigated. The results on curing behaviors indicated that the curing exothermic peaks of the blends with triazine-trione based tri-imidazole derivatives shifted to higher temperatures compared with those with commercial imidazoles. The curing exothermic peak temperatures (Tps) of the synthesized tri-imidazole derivatives were increased by 23–32 ℃ compared with the unmodified imidazoles. In addition, Rheological behavior results indicated that the EP blends with tri-imidazole derivatives also exhibited excellent storage stability which was as long as 38 days under room temperature. Last but not the least, the EP blends with triazine-trione based tri-imidazole derivatives also exhibited high glass transition temperatures due to introducing of triazine-trione structures with high crosslinking density. The glass transition temperatures (Tgs) of the prepared thermosets ranged from 128 to 152 ℃. The triazine-trione based tri-imidazole derivatives provide a way to prepare latency epoxy resin with high high glass transition temperature and long storage stability.Article HighlightsFour novel kinds of triazine-trione based tri-imidazole derivatives were synthesized.The EP cured with the tri-imidazole derivatives displayed great thermostability.The EP cured with the tri-imidazole derivatives exhibited long storage stability.
High-performance blockchain system for fast certification of manufacturing data
Authors: Costa Diogo , Teixeira Miguel , Pinto Armando N. , Santos José 
Published: December 2021

AbstractIntegration of blockchain systems into industrial applications show promise in increasing security, trust, and transparency along the value-chain during product and process tracking. However, current solutions suffer performance deficiencies, or often disregard legacy devices still in operation. We propose a blockchain system built upon an IoT architecture that is secure, modular, easily scalable, and deployable for fast certification of manufacturing data, compatible with current industrial landscapes. First, the proposed architecture is presented along with elements required to manage network functions. Second, easing integration with existing manufacturing solutions, custom APIs are created and subsequently explained. This grants the platform plug-and-play capabilities, requiring minimal hardware and software configuration for deployment. Lastly, a prototype is designed to validate the solution, concluding the viability of the proposed architecture as a fast and secure certification method of manufacturing data.
Roles of plant hormones in thermomorphogenesis
Authors: Lu Hai-Ping , Wang Jing-Jing , Wang Mei-Jing , Liu Jian-Xiang 
Published: December 2021

AbstractGlobal warming has great impacts on plant growth and development, as well as ecological distribution. Plants constantly perceive environmental temperatures and adjust their growth and development programs accordingly to cope with the environment under non-lethal warm temperature conditions. Plant hormones are endogenous bioactive chemicals that play central roles in plant growth, developmental, and responses to biotic and abiotic stresses. In this review, we summarize the important roles of plant hormones, including auxin, brassinosteroids (BRs), Gibberellins (GAs), ethylene (ET), and jasmonates (JAs), in regulating plant growth under warm temperature conditions. This provides a picture on how plants sense and transduce the warm temperature signals to regulate downstream gene expression for controlling plant growth under warm temperature conditions via hormone biosynthesis and signaling pathways.
Sexual Function of Women with Deep Endometriosis Before and After Surgery: A Prospective Study
Authors: Dior Uri P. , Reddington Charlotte , Cheng Claudia , Levin Gabriel , Healey Martin 
Published: December 2021

ABSTRACT

Background
Deep endometriosis (DE) may significantly affect women’s quality of life. Limited data exists on the effect of surgery on the several domains of sexual function.

Aim
To prospectively compare various domains of sexual function before and after laparoscopic surgery for DE.

Methods
A prospective observational cohort study in a tertiary university-affiliated referral center. Patients with suspected DE who were planned to undergo laparoscopic surgery completed the Female Sexual Function Index questionnaire before surgery. The same questionnaire was completed by the participants 6 weeks, 6 months, and 12 months after surgery. Rate of sexual dysfunction over time was compared using multilevel logistic regression. Summary scores were then compared at each time point to the corresponding score before surgery using multilevel linear regression. Multivariable analysis was performed of potential confounders.

Outcomes
Change in desire, arousal, orgasm, lubrication, satisfaction and pain summary scores as well as in the full-scale score between before and after surgery.

Results
We followed 149 patients with surgically confirmed DE. Sexual dysfunction rate as per the full-scale score was 75.5% before surgery and remained over 60% to 12 months after. The full-scale sexual function score improved at 6 (change in score = 2.8 ± 9.5, P = .004) and 12 months (change in score = 2.1 ± 9.9, P = .03). None of the summary scores improved at 6 weeks. Desire score (P &lt; .001), arousal score (P = .02), and pain score (P = .01) improved at 6 months. Desire score (P = .03) and pain score (P = .01) also improved at 12 months, as compared to before surgery. On multivariable multilevel analysis, scores before surgery significantly contributed to the scores after surgery (P &lt; .001).

Clinical translation
While sexual function improved after surgery, dysfunction rate remained substantial. Proper preoperative counseling should address sexual function measures and clinical and research attention should be given to seek ways to further reduce sexual dysfunction.

Strengths and limitations
The main strengths of our study are the prospective design, the relatively long follow-up and the use of a detailed validated questionnaire allowing assessment of a large variety of clinically relevant sexual function domains and scores as well as a full-scale score. Among our limitations are the lower response rate at 12 months and the limited generalizability as this is a single center study.

Conclusion
Sexual function is a major and often under reported domain of quality of life. Further research is needed to identify the specific populations who may improve, not change or experience deterioration in their sexual functioning after surgery.
Inter‐Hemispheric Coupling During Sudden Stratospheric Warming Events With Elevated Stratopause
Authors: Naren Athreyas Kashyapa , Garcia Rolando , Chandran Amal 
Published: December 2021

AbstractSudden stratospheric warmings (SSW) are large‐scale disruptions of the wintertime state of the stratosphere that can affect the circulation at synoptic and global scales, including altitudes up to the mesopause in both winter and summer hemispheres. In this study, the response of the summer mesosphere is analyzed during the SSW in the winter stratosphere. In particular, we focus on major SSW events where the climatological stratopause disappears and subsequently reforms at higher altitude, which we refer to as “extreme SSW” in this article. The summer mesosphere response to such extreme SSW events is analyzed in three different phases: (a) stratosphere warming phase, (b) stratopause discontinuity phase, and (c) stratopause reformation phase. Composites of anomalies with respect to climatology derived from the Microwave Limb Sounder and the extended version of the Whole Atmosphere Community Climate Model with specified dynamics are analyzed. The polar summer mesosphere cools during the stratospheric warming phase and warms in subsequent phases. A detailed lag‐correlation analysis shows strong negative correlation of −0.6 to −0.8 between the summer mesosphere and the winter stratosphere during the stratosphere warming phase, and a positive correlation of 0.4–0.6 in the phases thereafter. An attempt is made to explain the apparent drivers and dynamics responsible for these couplings, supported with evidence from observations and model output.
Sediment Recruitment and Redistribution in Mountain Channel Networks by Post‐Wildfire Debris Flows
Authors: Morell K. D. , Alessio P. , Dunne T. , Keller E. 
Published: December 2021

AbstractWe used lidar differencing and field observations to map volumes, and interpret the origins of, sediment mobilized from mountain canyons by large post‐wildfire debris flows near Montecito, CA, USA in 2018. The debris flows progressively entrained and partially redeposited 550,000 m3 of previously stored channel sediments throughout the canyon networks. The observations that scour depths and volumes were highest where the largest volumes of bouldery colluvium and debris‐flow deposits had accumulated, and that scour persisted beyond the mountain front, indicates that debris‐flow volumes in this extreme event were ultimately controlled by the coarse sediment reservoir available for scour. Because the volumes of available stored sediment result from the stochastic interaction of colluvial mass wasting, the magnitude and frequency of previous debris flows, and the accommodation space provided by valley morphology, the study reinforces the importance of estimating stored sediment volumes when developing debris‐flow hazard assessments.
Optimal Growth of IPV Lags AMV Modulations by up to a Decade
Authors: Yang Jun‐Chao , Zhang Yu , Lin Xiaopei , Chang Ping 
Published: December 2021

AbstractThe Interdecadal Pacific Variability (IPV) has global climate effects but its decadal prediction is a challenge. Here, we use linear inverse models to study the optimal growth of the IPV and reveal important precursor patterns. We find that the optimal growth of the IPV exists in observations due to interference among various sea surface temperature (SST) decadal variations. Small SST anomalies extending from the northeastern subtropical Pacific to the central tropical Pacific, in concert with thermocline dynamics, can develop into a mature phase of the IPV after ∼3 years. Furthermore, the initial SST anomalies lag the Atlantic Multidecadal Variability (AMV) by up to a decade, suggesting the potential importance of the AMV in IPV decadal predictability. As climate models commonly underestimate the AMV trans‐basin effect, our study calls for more efforts on reducing the model bias to improve IPV decadal prediction.
A Benthic Monitor for Coastal Water Dissolved Oxygen Variation: Mn/Ca Ratios in Tests of an Epifaunal Foraminifer
Authors: Guo Xiaoyi , Wei Qinsheng , Xu Bochao , Burnett William C. , Bernhard Joan M. , Nan Haiming , Lian Ergang , Yang Shouye , Yu Zhigang 
Published: December 2021

AbstractAn appropriate proxy could help to better understand dissolved oxygen variations in the past, helping to predict potential outcomes of future environmental changes. In the Changjiang Estuary (China), the foraminifer Cribrononion subincertum (C. subincertum) shows a distinct population maximum in the topmost sediment, an indication of an epifaunal species. Therefore, the geochemical composition of C. subincertum tests could record changes in the region’s bottom water chemistry. Our results showed that Mn/Ca ratios in tests of living (Rose‐Bengal stained) C. subincertum analyzed by LA‐ICP‐MS were responsive to variations of bottom water dissolved oxygen concentrations, with average foraminiferal Mn/Ca ratios three times higher during low‐oxygen period than in winter. In the uppermost centimeters of sediment, wider ranges of foraminiferal Mn/Ca occurred in summer compared to winter ranges. Our results imply that this epifaunal benthic foraminiferal species could serve as a useful benthic monitor with the Mn/Ca ratios representing a reliable proxy of hypoxia in the past.
Aerosol Physical‐Optical Properties and PBLH Under Different Air Pollution Levels From Ground Lidar and Satellite Observations Over Shouxian Area, China
Authors: Zhang Yuan , Wei Fan , Luo Hao , Su Yueyuan , Feng Yan , Huang Yong , Yang Jun , Wu Yonghua , Han Yong 
Published: December 2021

AbstractThe physical and optical properties of aerosols and the change of planetary boundary layer height (PBLH) are of great scientific significance for the study of atmospheric environment and air quality. This paper intends to present integrated observations of aerosol physical‐optical characteristics and PBLH properties under different air pollution levels in Shouxian (National Climatology Observatory (32°26’ N, 116°47’ E)), China. The combined measurements of ground‐based Lidar and Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) are analyzed from December 2016 to November 2017 in this study. Results show that the extinction coefficients decrease significantly with height below 2 km. The extinction coefficients below 1 km, the aerosol optical depth (AOD), and the PBLH increase with the aggravation of pollution. The daily average aerosol extinction coefficient near the surface is about 0.78 km−1, the AOD is 0.87 ± 0.33 m (mean ± std, the same below), and the PBLH is 827 ± 132 m in polluted conditions (PM2.5 > 115 μg m−3). With the increase in pollution and the decrease in PBLH, more aerosols are accumulated at a lower height. The daily average ratios of AOD below PBLH (AODPBLH) to total AOD (AODtot) are about 64% in polluted conditions. According to the CALIPSO‐observed aerosol vertical profile, aerosols are identified for about 20.54% of the vertical space below 6 km altitude under polluted conditions. The spherical fine particles with lower particulate depolarization ratio (PDR, 79% of the PDR is <0.2), lower color ratio (CR, 64% of the CR is <0.75), and stronger scattering ability are dominant in 0∼2 km.
Rainfall Stable Water Isotope Variability in Coastal Southwestern Western Australia and Its Relationship to Climate on Multiple Timescales
Authors: Griffiths Alan D. , Treble Pauline C. , Hope Pandora , Rudeva Irina 
Published: December 2021

AbstractThe factors driving variability in rainfall stable water isotopes (specifically δ18O and deuterium excess, d = δ2H − 8 δ18O) were studied in a 13‐year data set of daily rainfall samples from coastal southwestern Western Australia (SWWA). Backwards dispersion modeling, automatic synoptic type classification, and a statistical model were used to establish causes of variability on a daily scale; and predictions from the model were aggregated to longer temporal scales to discover the cause of variability on multiple timescales. Factors differ between δ18O and d and differ according to temporal scale. Rainfall intensity, both at the observation site and upwind, was most important for determining δ18O and this relationship was robust across all time scales (daily, seasonal, and interannual) as well as generalizing to a second observation site. The sensitivity of δ18O to rainfall intensity makes annual mean values particularly sensitive to the year's largest events. Projecting the rainfall intensity relationship back through ∼100 years of precipitation observations can explain ∼–0.4‰ shifts in rainfall δ18O. Twentieth century speleothem records from the region exhibit signals of a similar magnitude, indicating that rainfall intensity should be taken into account during the interpretation of regional climate archives. For d, humidity during evaporation from the ocean was the most important driver of variability at the daily scale, as well as explaining the seasonal cycle, but source humidity failed to explain the longer‐term interannual variability.
Mesospheric Short‐Period Gravity Waves in the Antarctic Peninsula Observed in All‐Sky Airglow Images and Their Possible Source Locations
Authors: Kam Hosik , Song In‐Sun , Kim Jeong‐Han , Kim Yong Ha , Song Byeong‐Gwon , Nakamura Takuji , Tomikawa Yoshihiro , Kogure Masaru , Ejiri Mitsumu K. , Perwitasari Septi , Tsutsumi Masaki , Kwak Young‐Sil 
Published: December 2021

AbstractThis study presents an analysis of OH airglow images observed from an all‐sky camera (ASC) at King Sejong Station (KSS), Antarctic for the 2012–2016 period. The two‐dimensional power spectra of short‐period gravity waves (<1 hr) as a function of phase velocities are obtained using the M‐transform method that employs the time sequence of ASC images. The amplitudes of the power spectral densities show that the mesospheric wave activity is the largest during winter (May, June, and July) and is the smallest in fall (February, March, and April). Wind‐blocking diagrams are constructed on the same two‐dimensional domain as in the two‐dimensional spectra using horizontal winds obtained from MERRA‐2 reanalysis at z = 0–80 km and from KSS meteor radar data at z = 80–90 km. Climatologically, the spectral regions of slowly propagating gravity waves (<30 m s−1) are overlaid by the wind‐blocking areas, which suggests the filtering of gravity waves with small phase speeds by winds below the upper stratosphere. Eastward propagating gravity waves in winter and intense south‐eastward waves in spring (October) are found to be unfiltered by the stratospheric winds. It is also found from the spectral analysis that these unfiltered gravity waves can originate from the upper stratosphere or the lower mesosphere, and not from the troposphere, which suggests the possibility of ASC observation of the secondary gravity waves generated near the stratopause.
Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors
Authors: You Zhi-Bing , Galaj Ewa , Alén Francisco , Wang Bin , Bi Guo-Hua , Moore Allamar R. , Buck Tristram , Crissman Madeline , Pari Sruti , Xi Zheng-Xiong , Leggio Lorenzo , Wise Roy A. , Gardner Eliot L. 
Published: December 2021

AbstractCocaine addiction is a significant medical and public concern. Despite decades of research effort, development of pharmacotherapy for cocaine use disorder remains largely unsuccessful. This may be partially due to insufficient understanding of the complex biological mechanisms involved in the pathophysiology of this disorder. In the present study, we show that: (1) elevation of ghrelin by cocaine plays a critical role in maintenance of cocaine self-administration and cocaine-seeking motivated by cocaine-conditioned stimuli; (2) acquisition of cocaine-taking behavior is associated with the acquisition of stimulatory effects of cocaine by cocaine-conditioned stimuli on ghrelin secretion, and with an upregulation of ghrelin receptor mRNA levels in the ventral tegmental area (VTA); (3) blockade of ghrelin signaling by pretreatment with JMV2959, a selective ghrelin receptor antagonist, dose-dependently inhibits reinstatement of cocaine-seeking triggered by either cocaine or yohimbine in behaviorally extinguished animals with a history of cocaine self-administration; (4) JMV2959 pretreatment also inhibits brain stimulation reward (BSR) and cocaine-potentiated BSR maintained by optogenetic stimulation of VTA dopamine neurons in DAT-Cre mice; (5) blockade of peripheral adrenergic β1 receptors by atenolol potently attenuates the elevation in circulating ghrelin induced by cocaine and inhibits cocaine self-administration and cocaine reinstatement triggered by cocaine. These findings demonstrate that the endogenous ghrelin system plays an important role in cocaine-related addictive behaviors and suggest that manipulating and targeting this system may be viable for mitigating cocaine use disorder.
Transformation and outcome of nodular lymphocyte predominant Hodgkin lymphoma: a Finnish Nationwide population-based study
Authors: Kalashnikov Ilja , Tanskanen Tomas , Pitkäniemi Janne , Malila Nea , Jyrkkiö Sirkku , Leppä Sirpa 
Published: December 2021

AbstractNodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare B-cell malignancy associated with excellent survival. However, some patients experience histological transformation into aggressive large B-cell lymphoma. Population-based data on transformation in patients with NLPHL is limited. We conducted a nationwide population-based study to estimate the risk of transformation and relative survival in patients diagnosed with NLPHL in Finland between 1995 and 2018. We identified a total of 453 patients (median age, 48 years; 76% males) with the incident NLPHL from the Finnish Cancer Registry. The cumulative incidence of transformation was 6.3% (95% CI, 4.2-9.6) at 10 years. After adjusting for sex, age and year of diagnosis, transformation was associated with a substantially increased risk of death (HR 8.55, 95% CI 4.49−16.3). Ten-year relative survival was 94% (95% CI, 89%‒100%). The patients diagnosed at a later calendar year had lower excess risk of death (HR, 0.38 per 10-year increase; 95% CI, 0.15‒0.98). We conclude that while the 10-year relative survival for the patients with NLPHL was excellent in this large population-based cohort for the entire study period, transformation resulted in a substantially increased mortality compared with the patients without transformation. Our results also suggest a reduction in excess mortality over time.
Longitudinal study of stool-associated microbial taxa in sibling pairs with and without autism spectrum disorder
Authors: Tataru Christine , Martin Austin , Dunlap Kaitlyn , Peras Marie , Chrisman Brianna S , Rutherford Erica , Deitzler Grace E , Phillips Alexandra , Yin Xiaochen , Sabino Kayleen , Hannibal Roberta L , Hartono Wiputra , Lin Michelle , Raack Edward , Wu Yonggan , DeSantis Todd Z , Iwai Shoko , Wall Dennis P , David Maude M 
Published: December 2021

Abstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder influenced by both genetic and environmental factors. Recently, gut dysbiosis has emerged as a powerful contributor to ASD symptoms. In this study, we recruited over 100 age-matched sibling pairs (between 2 and 8 years old) where one had an Autism ASD diagnosis and the other was developing typically (TD) (432 samples total). We collected stool samples over four weeks, tracked over 100 lifestyle and dietary variables, and surveyed behavior measures related to ASD symptoms. We identified 117 amplicon sequencing variants (ASVs) that were significantly different in abundance between sibling pairs across all three timepoints, 11 of which were supported by at least two contrast methods. We additionally identified dietary and lifestyle variables that differ significantly between cohorts, and further linked those variables to the ASVs they statistically relate to. Overall, dietary and lifestyle features were explanatory of ASD phenotype using logistic regression, however, global compositional microbiome features were not. Leveraging our longitudinal behavior questionnaires, we additionally identified 11 ASVs associated with changes in reported anxiety over time within and across all individuals. Lastly, we find that overall microbiome composition (beta-diversity) is associated with specific ASD-related behavioral characteristics.