bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning-Based Ultrasomics Improves the Diagnostic Performance in Differentiating Focal Nodular Hyperplasia and Atypical Hepatocellular Carcinoma
Authors: Li Wei , Lv Xiao-Zhou , Zheng Xin , Ruan Si-Min , Hu Hang-Tong , Chen Li-Da , Huang Yang , Li Xin , Zhang Chu-Qing , Xie Xiao-Yan , Kuang Ming , Lu Ming-De , Zhuang Bo-Wen , Wang Wei 
Published: March 2021

BackgroundThe typical enhancement patterns of hepatocellular carcinoma (HCC) on contrast-enhanced ultrasound (CEUS) are hyper-enhanced in the arterial phase and washed out during the portal venous and late phases. However, atypical variations make a differential diagnosis both challenging and crucial. We aimed to investigate whether machine learning-based ultrasonic signatures derived from CEUS images could improve the diagnostic performance in differentiating focal nodular hyperplasia (FNH) and atypical hepatocellular carcinoma (aHCC).Patients and MethodsA total of 226 focal liver lesions, including 107 aHCC and 119 FNH lesions, examined by CEUS were reviewed retrospectively. For machine learning-based ultrasomics, 3,132 features were extracted from the images of the baseline, arterial, and portal phases. An ultrasomics signature was generated by a machine learning model. The predictive model was constructed using the support vector machine method trained with the following groups: ultrasomics features, radiologist’s score, and combination of ultrasomics features and radiologist’s score. The diagnostic performance was explored using the area under the receiver operating characteristic curve (AUC).ResultsA total of 14 ultrasomics features were chosen to build an ultrasomics model, and they presented good performance in differentiating FNH and aHCC with an AUC of 0.86 (95% confidence interval [CI]: 0.80, 0.89), a sensitivity of 76.6% (95% CI: 67.5%, 84.3%), and a specificity of 80.5% (95% CI: 70.6%, 85.9%). The model trained with a combination of ultrasomics features and the radiologist’s score achieved a significantly higher AUC (0.93, 95% CI: 0.89, 0.96) than that trained with the radiologist’s score (AUC: 0.84, 95% CI: 0.79, 0.89, P &lt; 0.001). For the sub-group of HCC with normal AFP value, the model trained with a combination of ultrasomics features, and the radiologist’s score remain achieved the highest AUC of 0.92 (95% CI: 0.87, 0.96) compared to that with the ultrasomics features (AUC: 0.86, 95% CI: 0.74, 0.89, P &lt; 0.001) and radiologist’s score (AUC: 0.86, 95% CI: 0.79, 0.91, P &lt; 0.001).ConclusionsMachine learning-based ultrasomics performs as well as the staff radiologist in predicting the differential diagnosis of FNH and aHCC. Incorporating an ultrasomics signature into the radiologist’s score improves the diagnostic performance in differentiating FNH and aHCC.
Complete Blood Count Score Model Predicts Inferior Prognosis in Primary Central Nervous System Lymphoma
Authors: Feng Yuhua , Liu Yiping , Zhong Meizuo , Wang Leyuan 
Published: March 2021

BackgroundPrimary central nervous system lymphoma (PCNSL), an aggressive type of non-Hodgkin lymphoma, has a poor prognosis. Currently available prognostic scoring systems are inadequate. We therefore aimed to investigate the predictive values of complete blood counts (CBCs) in PCNSL.Materials and MethodsThe cohort of this retrospective study comprised 73 PCNSL patients. The predictive values of selected CBCs, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI), were analyzed.ResultsAges and Memorial Sloan Kettering Cancer Center (MSKCC) scores of PCNSL patients correlated with NLR, PLR, and SII values (p &lt;0.05). Both age and MSKCC scores correlated with inferior progression-free survival (PFS) and overall survival (OS) (p &lt;0.05). High NLR, PLR, SII, and SIRI were significant predictors of shorter PFS and OS (p &lt;0.05). NLR, PLR, SII, and SIRI were integrated to generate a “CBC score” model that accurately stratified PCNSL patients into three risk groups. The median PFS for low-risk, intermediate-risk, and high-risk groups were 24 ((12.458–35.542), 17 (10.626–23.374), and 9 (8.893–19.107) months, respectively (p = 0.011), and the median OS were 33 (19.175–46.825), 18 (16.368–19.632), and 9 (6.521–11.479) months, respectively (p = 0.008). Multivariate Cox regression model showed that MSKCC score (hazard ratio (HR) = 3.791, p &lt;0.001), PLR (HR = 1.003, p = 0.013), and CBC score (HR = 1.873, p = 0.011) were independent predictors for PFS, whereas MSKCC score (HR = 4.128, p &lt;0.001), PLR (HR = 1.003, p = 0.005), and CBC score (HR = 1.907, p = 0.004) were independent predictors for OS.ConclusionThe CBC score model may be a promising predictive system for PCNSL patients.
Depression and Anxiety Among Quarantined People, Community Workers, Medical Staff, and General Population in the Early Stage of COVID-19 Epidemic
Authors: Li Xiaoling , Yu Hegao , Yang Weiqiang , Mo Qihua , Yang Zhanggui , Wen Shuangshuang , Zhao Fei , Zhao Weishun , Tang Yongyan , Ma Liang , Zeng Ruifen , Zou Xia , Lin Hanli 
Published: March 2021

Background: We described the prevalence of anxiety and depression related to COVID-19 pandemic among different types of population and examined their potential risk factors.Methods: A cross-sectional survey was conducted to collect demographic characteristics, exposure histories, and many other concerns about COVID-19. The Zung's self-rating anxiety scale (SAS) and self-rating depression scale (SDS), followed by a four-step multiple logistic regression analysis was performed to identify factors associated with mental health outcomes.Results: Out of 3,303 participants, the quarantined people (40.9%), community workstation staffs-policemen-volunteers (CPV) (36.4%) and general public (30.7%) reported higher percentages of depression than the general medical staff (18.4%). Moreover, the quarantined people (19.1%) also showed higher prevalence of anxiety than the general public (9.1%) and the general medical staff (7.8%). The quarantined people had the highest risk of anxiety and depression, whereas the self-rated health was negatively associated with the risks of anxiety and depression. Younger age group (18 to 30 years) showed higher risks of anxiety (OR = 6.22, 95% CI = 2.89–13.38, p &lt; 0.001) and depression (OR = 3.69, 95% CI = 2.40–5.69, p &lt; 0.001). People who had exposure history or contact from Hubei province after December 1, 2019 (OR = 1.57, 95% CI = 1.07–2.30, p &lt; 0.001), had family or friends engaged in front-line health care work (OR = 1.47, 95% CI = 1.02–2.14, p &lt; 0.001), had confirmed case nearby (OR = 2.44, 95% CI = 1.43–4.18, p &lt; 0.001) were all more likely to suffer from anxiety. Moreover, the negligence (OR = 1.85, 95% CI = 1.37–2.51, p &lt; 0.001) or overindulgence (OR = 1.45, 95% CI = 1.03–2.04, p &lt; 0.001) toward the epidemic information was associated with a higher risk of depression and anxiety.Conclusions: Our findings show that the CPV and quarantined people were most at-risk population. We have identified that the young people, people with exposure histories and negligence or overindulgence toward epidemic information are in grave need of attention.
Factors Associated With Healthcare Workers' Insomnia Symptoms and Fatigue in the Fight Against COVID-19, and the Role of Organizational Support
Authors: Zou Xia , Liu Shaokun , Li Jie , Chen Wen , Ye Jiali , Yang Yuan , Zhou Fenfen , Ling Li 
Published: March 2021

Background: Healthcare workers (HCWs) have been exposed to increased risks of insomnia and fatigue during the COVID-19 pandemic. In this study, we identify important risk factors associated with insomnia symptoms and fatigue among HCWs, and evaluate the effect of organizational support on insomnia and fatigue symptoms.Methods: This is an online cross-sectional survey of HCWs in China administered during the COVID-19 epidemic (from February 27, 2020 to March 12, 2020). We employed the AIS-8 scale for insomnia screening, and a self-reported ten-point scale to evaluate subjects' degrees of fatigue. We also designed a four-point scale to assess the degree of social support provided on an organizational level. Additionally, we conducted logistic regression analysis to identify risk factors.Results: This study included a total of 3,557 participants, 41% of which consisted of non-frontline HCWs and 59% of which was frontline HCWs. Of the non-frontline HCWs, 49% reported insomnia symptoms, and 53.8% reported a moderate to high degree of fatigue. Meanwhile, among the frontline HCWs, the percentages for insomnia and moderate to high fatigue were 63.4% and 72.2%, respectively. Additionally, frontline HCWs and HCWs employed at Centers for Disease Control and Prevention (CDCs) had elevated risks of insomnia and fatigue. However, with increased organizational support, insomnia symptoms decreased among frontline HCWs. Also, organizational support mitigated the positive correlation between daily working hours and degree of fatigue among HCWs.Conclusion: Frontline HCWs and staff in Chinese CDCs have been at a high risk of insomnia symptoms and fatigue during the fight against COVID-19. This study provides evidence for the positive effects of organizational support in relation to insomnia and fatigue among HCWs. This sheds light on government responses to the COVID-19 epidemic for other countries.
A Scooping-Binding Robotic Gripper for Handling Various Food Products
Authors: Wang Zhongkui , Furuta Haruki , Hirai Shinichi , Kawamura Sadao 
Published: March 2021

Food products are usually difficult to handle for robots because of their large variations in shape, size, softness, and surface conditions. It is ideal to use one robotic gripper to handle as many food products as possible. In this study, a scooping-binding robotic gripper is proposed to achieve this goal. The gripper was constructed using a pneumatic parallel actuator and two identical scooping-binding mechanisms. The mechanism consists of a thin scooping plate and multiple rubber strings for binding. When grasping an object, the mechanisms actively makes contact with the environment for scooping, and the object weight is mainly supported by the scooping plate. The binding strings are responsible for stabilizing the grasping by wrapping around the object. Therefore, the gripper can perform high-speed pick-and-place operations. Contact analysis was conducted using a simple beam model and a finite element model that were experimentally validated. Tension property of the binding string was characterized and an analytical model was established to predict binding force based on object geometry and binding displacement. Finally, handling tests on 20 food items, including products with thin profiles and slippery surfaces, were performed. The scooping-binding gripper succeeded in handling all items with a takt time of approximately 4 s. The gripper showed potential for actual applications in the food industry.
Risk Perception and Emotion Reaction of Chinese Health Care Workers Varied During COVID-19: A Repeated Cross-Sectional Research
Authors: Qianlan Yin , Ying Liu , Aibin Chen , Xiangrui Song , Wenpeng Cai , Guanghui Deng , Wei Dong 
Published: March 2021

Objectives: To examine risk perception and negative emotions during two periods of the COVID-19 and provide plausible intervention points for the psychological aid under a stressful condition.Methods: The current study adopted the repeated cross-sectional research and was participated by a cohort of Chinese HCWs who were assigned to work at the current disease resistance line. The between-group information about gender, profession, and location was collected in the demographic questionnaire. Risk perception questionnaire was adapted for COVID-19 to assess risk perception and the Chinese version of emotional self-rating scale (PANAS) was used to evaluate HCWs’ negative emotions.Results: Findings revealed the risk perception and negative emotions of HCWs varied in different gender, profession, location, as well as different periods of COVID-19. Over the different periods, the predominated negative emotion expressed by HCWs varied, but negative emotion was consistently associated with risk perception and could be a significant indicator of risk perception.Conclusion: The significance of this research lies in its examination of risk perception and negative emotions of HCWs confronting the COVID-19 during two periods of the pandemic, which underscored the importance of monitoring the risk perception and negative emotions of HCWs to ensure safety and prevent the return of the pandemics.
The Transcription Factor Sox6 Controls Renin Expression during Renal Artery Stenosis
Authors: Saleem Mohammad , Saavedra-Sánchez Luz , Barturen-Larrea Pierina , Gomez Jose A. 
Published: March 2021

Abstract

Key Points

Sox6 controls the increased renin expression that is induced during renal artery stenosis, and thus has a novel function in renovascular hypertension.Sox6 knockout in Ren1d+ cells inhibited the renovascular hypertension and kidney injury induced by renal artery stenosis.The results presented in this manuscript point to a new transcriptional regulatory network in renal artery stenosis which is controlled by Sox6.

Background
Renal artery stenosis (RAStenosis) or renal artery occlusion is an intractable problem affecting about 6% of people >65 and up to 40% of people with coronary or peripheral vascular disease in the Unites States. The renal renin-angiotensin-aldosterone system plays a key role in RAStenosis, with renin (which is mainly produced in the kidney) being recognized as the driver of the disease. In this study, we will determine a new function for the transcription factor Sox6 in the control of renal renin during RAStenosis.

Methods
We hypothesize that knocking out Sox6 in Ren1d-positive cells will protect mice against renovascular hypertension and kidney injury. To test our hypothesis, we used a new transgenic mouse model, Ren1dcre/Sox6fl/fl (Sox6 KO), in which Sox6 is knocked out in renin-expressing cells. We used a modified two-kidney, one-clip (2K1C) Goldblatt mouse model to induce RAStenosis and renovascular hypertension. BP was measured using the tail-cuff method. Renin, prorenin, Sox6, and NGAL expressions levels were measured with Western blot, in situ hybridization, and immunohistochemistry. Creatinine levels were measured using the colorimetric assay.

Results
Systolic BP was significantly lower in Sox6 KO 2 weeks after RAStenosis compared with Sox6 WT (Ren1dcre/Sox6wt/wt). Renin, prorenin, and NGAL expression levels in the stenosed kidney were lower in Sox6 KO compared with Sox6 WT mice. Furthermore, creatinine clearance was preserved in Sox6 KO compared with Sox6 WT mice.

Conclusions
Our data indicate that Sox6 controls renal renin and prorenin expression and, as such, has a function in renovascular hypertension induced by RAStenosis. These results point to a novel transcriptional regulatory network controlled by Sox6.
Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation
Authors: Miyazaki-Anzai Shinobu , Masuda Masashi , Shiozaki Yuji , Keenan Audrey L. , Chonchol Michel , Kremoser Claus , Miyazaki Makoto 
Published: March 2021

Key Points

CKD increases levels of DCA, which induces endoplasmic reticulum stress in vascular smooth muscle cells and vascular calcification.Inhibition of FXR selectively increases DCA, resulting in severe vascular calcification.Inhibition of ATF4 in vascular smooth muscle cells blocks DCA-induced vascular calcification in vitro and in vivo.

Background
Our metabolome approach found that levels of circulating, free deoxycholic acid (DCA) is associated with the severity of vascular calcification in patients with CKD. However, it is not known whether DCA directly causes vascular calcification in CKD.

Methods
Using various chemicals and animal and cell culture models, we investigated whether the modulation of DCA levels influences vascular calcification in CKD.

Results
CKD increased levels of DCA in mice and humans by decreasing urinary DCA excretion. Treatment of cultured VSMCs with DCA but no other bile acids (BAs) induced vascular calcification and osteogenic differentiation through endoplasmic reticulum (ER) stress–mediated activating transcription factor-4 (ATF4) activation. Treatment of mice with Farnesoid X receptor (FXR)–specific agonists selectively reduced levels of circulating cholic acid–derived BAs, such as DCA, protecting from CKD-dependent medial calcification and atherosclerotic calcification. Reciprocal FXR deficiency and DCA treatment induced vascular calcification by increasing levels of circulating DCA and activating the ER stress response.

Conclusions
This study demonstrates that DCA plays a causative role in regulating CKD-dependent vascular diseases through ER stress–mediated ATF4 activation.
Effects of incomplete ionization on forward current–voltage characteristics of p-type diamond Schottky barrier diodes based on numerical simulation
Authors: Seok Ogyun , Ha Min-Woo 
Published: March 2021

Abstract
The forward current–voltage characteristics of p-type diamond pseudo-vertical Schottky barrier diodes are investigated via numerical simulation. Impact ionization decrease the hole concentration of the p− drift layer from 1015 to 1014 cm–3 at 300 K, thereby increasing the forward voltage drop and on-resistance. When we consider an incomplete ionization with increasing temperature, the increase in the hole concentration is more dominant than the enhanced phonon scattering, thereby resulting in an increasing forward current. We modified the Ohmic contact for both metallic conduction at the p+ layer and incomplete ionization at the p– drift layer. The Baliga figure-of-merit of the device with and without incomplete ionization is 25 and 192 MW cm−2, respectively. Incomplete ionization should be considered in the numerical study of diamond power devices.
Upaya Meningkatkan Kinerja Guru Melalui Supervisi Akademik dengan Teknik Individual di SMPN 9 Depok
Authors: Salim Bangun  
Published: March 2021

Sebagai tenaga profesional, guru perlu memiliki kemampuan khusus, yang tidak mungkin dilakukan oleh mereka yang bukan guru. Tujuan penelitian ini untuk membantu guru mengembangkan kemampuannya dalam mencapai tujuan pembelajaran yang direncanakan bagi murid-muridnya melalui Supervisi Akademik. Metode penelitian ini yaitu Penelitian Tindakan Sekolah yang dilaksanakan pada bulan Juli 2020 sampai dengan Desember 2020. Subjek penelitiannya yaitu guru SMP Negeri 9. Instrumen yang digunakan dalam penelitian ini adalah observasi dan wawancara dengan menggunakan formulir wawancara, RPP, pengamatan pembelajaran dan penelitian administrasi. Berdasarkan hasil penelitian yaitu nilai rata-rata evaluasi kinerja guru dari pra siklus ke siklus 1 meningkat 8 poin, dan evaluasi guru dari siklus 1 ke siklus 2 meningkat 11 poin Hal ini dapat dilihat jumlah guru yang masuk kategori “baik” pada pra siklus adalah dari 0% menjadi 40% pada siklus 1 dan 2. Pada saat yang sama, jumlah guru di kategori pra-siklus "sangat baik" adalah 0%, meningkat menjadi 40% dalam siklus
Analisis Yuridis Penegakkan Hukum Dinas Perhubungan DKI Jakarta Terhadap Pemilik Kendaraan Yang Terparkir Tidak Pada Tempatnya
Authors: Juwita  , Yose Rizal  
Published: March 2021

Tujuan Penelitian ini adalah untuk mengetahui dan menganalisa secara yuridis Penegakan Hukum yang Dilakukan Dinas Perhubungan DKI Jakarta Terhadap Pemilik Mobil Yang Terparkir Tidak Pada Tempatnya dan untuk mengetahui dan menganalisa Penerapan sanksi terhadap Pemilik Mobil Yang Terparkir Tidak Pada Tempatnya. Metode Penelitian yang digunakan adalah jenis penelitian yuridis normatif dan empiris yaitu penelitian yang meletakan norma hukum sebagai bangunan sitem norma dikaitkan dengan gejala dan peristiwa serta fenomena yang terjadi di masyarakat, lembaga atau negara yang bersifat non pustaka dengan melihat fenomena yang terdapat di masyarakat. Hasil penelitian ini menunjukan bahwa penegakkan hukum yang dilakukan terhadap pengendara yang parkir tidak pada tempatnya adalah terdapat pada pasal 95 perda no. 5 Tahun 2014 tentang Transfortasi dengan sanksi administrasi berupa denda Rp. 500.000,- perhari dan apabila tidak dilakukan proses pengambilan tetap akan dikumulatif perharinya
Analisis Keputusan Membeli Berbasis Brand Awareness sebagai Impak Google Ads dan Facebook Ads (Kajian Pelanggan Lazada)
Authors: Sijabat Bertinus 
Published: March 2021

Penelitian ini bertujuan untuk menguji analisis keputusan pembelian berbasis Brand Awareness sebagai dampak pada Google Ads dan iklan Facebook. Penelitian dilakukan terhadap 97 responden yang merupakan pelanggan Lazada. Hasil penelitian ini menunjukkan: 1). Variabel Google Ads (X1) dengan brand awareness (Y1) terbukti memiliki efek dan efek yang signifikan terhadap brand awareness, dengan parameter koefisien 0,5081 (P Value <0,05) sebesar 0,0000. Hal ini menunjukkan bahwa variabel Google Ads memiliki efek signifikan pada variabel brand awareness (Y1). 2). Variabel iklan Facebook (X2) dengan brand awareness (Y1) terbukti berpengaruh dan signifikan terhadap brand awareness dengan parameter koefisien 0,3447 dan P Value < 0,05 dari 0,0000. Ini menunjukkan bahwa variabel Iklan Facebook mempengaruhi variabel brand awareness (Y1). 3). Variabel Google Ads (X1) dengan keputusan pembelian (Y2) terbukti memiliki efek signifikan pada keputusan pembelian dengan parameter koefisien 0,2385 dan nilai P<0,05 sebesar 0,0009. Ini menunjukkan bahwa variabel Google Ads mempengaruhi variabel keputusan pembelian (Y2). 4). Variabel iklan Facebook (X2) dengan keputusan pembelian (Y2) terbukti memiliki efek dan efek yang signifikan pada keputusan pembelian yaitu dengan parameter koefisien 0,2761 dan P Value<0,05 dari 0,0020. Ini menunjukkan bahwa variabel iklan Facebook mempengaruhi variabel keputusan pembelian (Y2). 5). Variable brand awareness (Y1) dengan keputusan untuk membeli (Y2) terbukti berpengaruh dan signifikan terhadap keputusan pembelian dengan parameter koefisien 0,4497 dan nilai P < 0,05 dari 0,0000. Ini menunjukkan bahwa variabel Brand Awareness terbukti memiliki efek pada variabel keputusan pembelian (Y2).
Evaluasi Kerusakan Jalan Soekarno-Hatta STA 09+000-STA 14+000 Kota Balikpapan
Authors: Rio Wahyu Yusuf , Fatmawati Fatmawati 
Published: March 2021

Pada penelitian ini dilakukan survei kondisi kerusakan jalan dengan lokasi pada km 9 hingga km 14 (STA 9+00 - STA 14+00) dengan tujuan mengetahui kondisi kerusakan jalan dan penanganannya dengan menggunakan metode Bina Marga dan Pavement Condition Index. Berdasarkan hasil analisis metode Bina Marga diketahui tingkat kerusakan jalan pada STA 9+00-STA 14+00 memiliki area sebesar 941,12 m2, adapun prioritas tertinggi sebesar 5.2 pada STA 12+000-STA 13+000 dan nilai kondisi jalan adalah 6.8. Sedangkan dari analisis dengan metode PCI diperoleh hasil indeks kondisi perkerasan sangat rendah dengan nilai PCI 14 yakni pada STA 12+850 hingga STA 12+900 dengan kategori kerusakan sangat buruk. Dari hasil penilaian kerusakan jalan maka perlu dilakukan pemeliharaan rutin dan melakukan perbaikan berupa tambalan, perawatan permukaan serta penutupan retak dapat dijadikan rekomendasi perbaikan jalan. Dari hasil penilaian terhadap kondisi jalan di ruas jalan Soekarno-Hatta STA 9+000-STA 14+000 kota Balikpapan diperoleh nilai kondisi perkerasan persegmen yang mengalami kerusakan dan harus mendapatkan prioritas penangganan terlebih dahulu yaitu STA 13+300 sampai STA 13+350 diperoleh nilai PCI 14 yang berarti dalam kondisi sangat buruk (very poor), STA 12+850 sampai STA 12+900 diperoleh nilai PCI 14 yang berarti dalam kondisi sangat buruk (very poor), STA 10+250 sampai STA 10+300 diperoleh nilai PCI 42 yang berarti dalam kondisi buruk (poor), STA 10+600 sampai STA 10+650 diperoleh nilai PCI 31 yang berarti dalam kondisi buruk (poor).