bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality Among Neutropenic Cancer Patients Within the United States: The Association With Hospital Volume
Authors: Urban Damien , Urban Gavin E. , Margalit Ofer , Amit Uri , Jacobson Galia , Symon Zvi , Golan Talia , Boursi Ben , Lawrence Yaacov Richard 
Published: January 2021

PURPOSE: Neutropenia is a serious complication of chemotherapy in patients with solid tumors. The influence of hospital volume on outcomes in patients with neutropenia has been little investigated. We hypothesized that large-volume hospitals would have reduced mortality rates for neutropenic patients compared with small-volume institutions. METHODS: We used the Nationwide Inpatient Sample database of the Healthcare Cost and Utilization Project, for the years 2007-2011. All adult inpatient episodes with a diagnosis of both neutropenia and solid-tumor malignancy were included. Hospital volume was defined as the number of neutropenic cancer episodes per institution per year. Mortality was defined as death during admission. A multilevel mixed-effects logistic regression model was applied. RESULTS: Twenty thousand three hundred and ten hospitalizations were included in the study, from 1,869 different institutions. Median age was 62 years. The overall inpatient mortality was 2.3%, and was dependent on age (age 50-59 years—1.6% and age 80-89 years—5.3%). The median number of neutropenic inpatient episodes in each institution per year was 14 (range, 1-168). Mortality was 3.3%, 2.7%, 2.2%, 2.2%, and 1.2% for each quintile of hospital volume (from lowest to highest volume, P < .001). Likewise, the proportion discharged home was 85.7%, 90.3%, 91.5%, 92.7%, and 95.4% ( P < .001). The association between hospital volume and mortality remained significant after adjustment for patient-level and hospital-level variables. DISCUSSION: Patients with neutropenia hospitalized in large-volume institutions have a substantially lower mortality compared with those hospitalized at low-volume institutions. Further study is required to validate our findings or overcome potential biases, understand mechanism, and investigate how smaller institutions can improve outcomes.
Dipolar drift and collective instabilities of skyrmions in crossed nonuniform electric and magnetic fields in a chiral magnetic insulator
Authors: Andreev Pavel A. , Trukhanova Mariya Iv. 
Published: January 2021

Abstract
Skyrmions dynamics in the approximation of point-particle skyrmions is considered in the multiferroic insulators, where the spiral magnetic structure is accompanied by finite electric dipole moment. The skyrmion motion is studied in the gradients of perpendicular magnetic and electric fields. The nonuniform magnetic field with a fixed gradient magnitude leads to the spiral motion, where skyrmion circulates in the plane perpendicular to the direction of the magnetic field. The frequency of circulation is fixed by the derivative of the external magnetic field and the magnitude of the dipole moment. Application of the additional electric field leads to the drift motion of skyrmions resulting in the magneto-dipolar Hall effect, the electric field is perpendicular to the magnetic field, but their gradients have the same direction. Hydrodynamics of the gas of interacting skyrmions in the crossed nonuniform electric and magnetic fields shows the new type of hydrodynamical instability caused by the drift motion. Three regimes of instability are described.
Mapping coupled time-series onto a complex network
Authors: Ardalankia Jamshid , Askari Jafar , Sheykhali Somaye , Haven Emmanuel , Reza Jafari G. 
Published: January 2021

Abstract
In order to extract hidden joint information from two possibly uncorrelated time-series, we explored the measures of network science. Alongside common methods in time-series analysis of the economic markets, the mapping joint structure of two time-series onto a network provides insight into hidden aspects embedded in the couplings. We quantise the amplitude of two time-series and investigate relative simultaneous locations of those amplitudes. Each segment of a quantised amplitude is considered as a node. The simultaneity of the amplitudes of the two time-series is considered as the links in the network. The frequency of occurrences forms the weighted links. In order to extract information, we need to measure to what extent the coupling deviates from the coupling of two uncoupled series. Also, we need to measure to what extent the couplings inherit their charachteristics from a Gaussian distribution or a non-Gaussian distribution. We mapped the network from two surrogate time-series. The results show that the couplings of markets possess some features which diverge from the same features of the network mapped from white noise, and from the network mapped from two surrogate time-series. These deviations prove that there exist joint information and cross-correlation therein. By applying network's topological and statistical measures and the deformation ratio in joint probability distribution, we distinguished basic structures of cross-correlation and coupling of cross-markets. It was discovered that even two possibly known uncorrelated markets may possess some joint patterns with each other. Thereby, those markets should be examined as coupled and weakly coupled markets.
Interprofessional Abortion Opposition: A National Survey and Qualitative Interviews with Abortion Training Program Directors at U.S. Teaching Hospitals
Authors: Bennett Ariana H. , Freedman Lori , Landy Uta , Langton Callie , Ly Elizabeth , Rocca Corinne H. 
Published: January 2021

CONTEXTHospital policies and culture affect abortion provision. The prevalence and nature of colleague opposition to abortion and how this opposition limits abortion care in U.S. teaching hospitals have not been investigated.METHODSAs part of a mixed‐methods study, a nationwide survey of residency and site directors at 169 accredited obstetrics‐gynecology training programs was conducted in 2015–2016, and 18 in‐depth interviews with program directors were conducted in 2014 and 2017. The prevalence and nature of interprofessional opposition were examined using descriptive statistics, and regional differences were investigated using logistic regression. A modified grounded theoretical approach was used to analyze interview data.RESULTSAmong the 91% of survey respondents who reported that they or their colleagues had wanted or needed to provide abortions in the prior year, 69% faced opposition from colleagues. Most commonly, opposition came from nurses (58%), nursing administration (30%) and anesthesiologists (30%), manifesting as resistance to participating in or cooperating with procedures (51% and 38%, respectively). Fifty‐nine percent of respondents had denied care to patients in the prior year because of colleagues’ opposition. Respondents in the Midwest and South were more likely than those in the Northeast to deny abortion care to patients because of such opposition (odds ratios, 3.2 and 4.4, respectively). Interviews revealed how participants had to circumvent opposing colleagues, making abortion provision difficult and leading to delays in and, infrequently, denial of abortion care.CONCLUSIONSInterprofessional opposition to abortion is widespread in U.S. teaching hospitals. Interventions are needed that prioritize patients’ needs while recognizing the challenges hospital colleagues face in their abortion participation decisions.
All-fiber Fabry–Pérot interferometer for reducing noise on the basis of
differential structure
Authors: Liang Hongwei , Liu Dongdong , Kan Lingling 
Published: January 2021

In this study, we propose a new optical fiber interferometer based on
differential structure. The phase delay exists in the two output arms
of the coupler. When the interference signal passes through the phase
delay twice in the transmission, it produces a phase shift of

π

with the original signal. This
feature can be used to differentially reduce noise. The experimental
results show that the signal-to-noise ratio increases by 1.29 dB, and
the waveform of the reconstructed signal is reduced by 12 nm. Thus,
the structure can effectively improve the quality of the measured
signal.
High-stability, high-energy Nd:glass rod regenerative amplifier with compensation for cavity misalignment
Authors: Shi Yusen , Zhang Peng , Jiang Youen , Wang Jiangfeng , Zhou Li , Lu Xinghua , Fan Wei , Li Xuechun , Zhu Jianqiang 
Published: January 2021

We report on an Nd:glass large-mode rod regenerative amplifier with a pulse energy of 125 mJ at 1053 nm. The amplifier contains a linear-type resonator, which is designed in Stability Zone II with a misalignment sensitivity factor of 12.9 m. A method is proposed for analyzing the sensitivity of the mode displacement on the gain media to cavity misalignment, and the optimum solution to compensation for cavity misalignment is obtained and applied to the amplifier. The amplifier exhibits excellent energy stability with a fluctuation of 0.47% (RMS) within 7 h and high spatial beam quality with

M
2

=

1.17

. The beam pointing stability in the horizontal and vertical axes within 7 h is 2.7 and 3.6 µrad (RMS), respectively.
Starting dynamics of a linear-cavity femtosecond Mamyshev oscillator
Authors: Chen Yi-Hao , Sidorenko Pavel , Thorne Robert , Wise Frank 
Published: January 2021

Mamyshev oscillators can generate high-power femtosecond pulses, but
starting a mode-locked state has remained a major challenge due to the
suppression of continuous-wave lasing. Here, we study the starting
dynamics of a linear Mamyshev oscillator designed to generate
high-power femtosecond pulses while avoiding component damage.
Reliable starting to stable mode-locking is achieved with a
combination of modulation of the pump power and shifting of a filter
passband. The starting process is automated, with full electronic
control. The laser delivers 21-nJ pulses that are dechirped to 65 fs
in duration outside the cavity.
Intra-oscillator high harmonic generation in a thin-disk laser operating in the 100-fs regime
Authors: Fischer Julian , Drs Jakub , Labaye François , Modsching Norbert , Wittwer Valentin J. , Südmeyer Thomas 
Published: January 2021

We demonstrate that Kerr lens modelocking is well-suited for operating an ultrafast thin-disk laser with intra-oscillator high harmonic generation (HHG) in the 100-fs pulse duration regime. Exploiting nearly the full emission bandwidth of the gain material Yb:YAG, we generate 105-fs pulses with an intracavity peak power of 365 MW and an intracavity average power of 470 W. We drive HHG in argon with a peak intensity of ∼7⋅1013 W/cm2 at a repetition rate of 11 MHz. Extreme-ultraviolet (XUV) light is generated up to the 31st harmonic order (H31) at 37 eV, with an average power of ∼0.4 µW in H25 at 30 eV. This work presents a considerable increase in performance of XUV sources based on intra-oscillator HHG and confirms that this approach is a promising technology for simple and portable XUV sources at MHz repetition rates.
Ultra-low frequency dynamic strain detection with laser frequency drifting compensation based on a random fiber grating array
Authors: Wang Yuan , Lu Ping , Mihailov Stephen , Chen Liang , Bao Xiaoyi 
Published: January 2021

Dynamic strain sensing over a frequency range from 0.01 to 20 Hz can be used for monitoring earthquakes and volcanoes, charting rock and petroleum formations beneath the earth. However, significant laser frequency drifting (LFD) has limited the detection in this frequency range, especially for distributed frequency detection with phase optical time domain reflectometry (OTDR), where the LFD will introduce a time dependent noise destroying the dynamic strain reconstruction. In this study, a simple and effective method that utilizes the referenced random fiber grating to monitor the variation of laser frequency has been both theoretically analyzed and experimentally demonstrated. During the maximum up to 200 s data acquisition time, the frequency variation of a distributed feedback (DFB) laser with MHz linewidth is obtained from the referenced portion of sensing signal, and then the 1 Hz and 0.01 Hz dynamic strain variations with amplitude of 30 µ

ε

are reconstructed with strain measurement standard deviation of 66 n

ε

. Due to signal-to-noise ratio (SNR) enhanced Rayleigh traces from random fiber gratings, a minimum detectable frequency drifting of 7.28 MHz could be achieved over the optical frequency of

2

×

10

14

H
z

.
Burst-mode dual-comb spectroscopy
Authors: Zhang Yu , Weeks Reagan R. D. , Lecaplain Caroline , Harilal Sivanandan S. , Yeak Jeremy , Phillips Mark C. , Jones R. Jason 
Published: January 2021

We introduce a new, to the best of our knowledge, modality of dual-comb spectroscopy (DCS) that enables a simplified and powerful new approach for time-resolved measurements with increased acquisition rates. This “burst mode” form of DCS relies on the multiplexing of each probe pulse into a short train of pulses. With this approach we demonstrate a time-resolved series of absorption-based spectroscopic measurements of a laser-induced plasma using only a single laser ablation shot and identify 22 Nd lines not previously reported in the literature. The transmission spectra spanned 3.1 THz and were acquired at an effective acquisition rate of 25 kHz with 40 µs time resolution. This simple modification to

∼

100

M
H
z

level dual-comb systems provides a flexible approach for studying transient and low-duty-cycle events such as laser-induced plasmas, combustion, and explosive reactions.
Patient harm associated with serial phlebotomy and blood waste in the intensive care unit: A retrospective cohort study
Authors: Bodley Thomas , Chan Maverick , Levi Olga , Clarfield Lauren , Yip Drake , Smith Orla , Friedrich Jan O. , Hicks Lisa K. 
Published: January 2021

BackgroundIntensive care unit (ICU) patients are at high risk of anemia, and phlebotomy is a potentially modifiable source of blood loss. Our objective was to quantify daily phlebotomy volume for ICU patients, including blood discarded as waste during vascular access, and evaluate the impact of phlebotomy volume on patient outcomes.MethodsThis was a retrospective observational cohort study between September 2014 and August 2015 at a tertiary care academic medical-surgical ICU. A prospective audit of phlebotomy practices in March 2018 was used to estimate blood waste during vascular access. Multivariable logistic regression was used to evaluate phlebotomy volume as a predictor of ICU nadir hemoglobin < 80 g/L, and red blood cell transfusion.ResultsThere were 428 index ICU admissions, median age 64.4 yr, 41% female. Forty-four patients (10%) with major bleeding events were excluded. Mean bedside waste per blood draw (144 draws) was: 3.9 mL from arterial lines, 5.5 mL central venous lines, and 6.3 mL from peripherally inserted central catheters. Mean phlebotomy volume per patient day was 48.1 ± 22.2 mL; 33.1 ± 15.0 mL received by the lab and 15.0 ± 8.1 mL discarded as bedside waste. Multivariable regression, including age, sex, admission hemoglobin, sequential organ failure assessment score, and ICU length of stay, showed total daily phlebotomy volume was predictive of hemoglobin <80 g/L (p = 0.002), red blood cell transfusion (p<0.001), and inpatient mortality (p = 0.002). For every 5 mL increase in average daily phlebotomy the odds ratio for nadir hemoglobin <80 g/L was 1.18 (95% CI 1.07–1.31) and for red blood cell transfusion was 1.17 (95% CI 1.07–1.28).ConclusionA substantial portion of daily ICU phlebotomy is waste discarded during vascular access. Average ICU phlebotomy volume is independently associated with ICU acquired anemia and red blood cell transfusion which supports the need for phlebotomy stewardship programs.
Rapid visual detection of FecB gene expression in sheep
Authors: Liu Li , Hu Ruirui , Li Cunyuan , Li Xiaoyue , Ni Wei , Yao Rui , Zhang Mengdan , Li Huixiang , Xu Yueren , Ullah Yaseen , Hu Shengwei 
Published: January 2021

AbstractSheep play an important role in agricultural production and people’s lives, and fecundity is one of the most important economic traits of sheep for sheep breeders. The Booroola fecundity (FecB) gene has a certain correlation with litter size in sheep. Therefore, this study aims to detect FecB expression quickly, accurately and visually. Here, we used the nucleic acid dye SYBR Green I to detect FecB with the amplification refractory mutation system (ARMS), which can efficiently, rapidly, economically and visually detect FecB expression in sheep. After ARMS polymerase chain reaction (PCR), SYBR Green I was directly added to the ARMS products, and whether the sheep carried FecB was judged by directly observing the color change in the PCR tube. Homozygous (BB) or heterozygous (B+) samples with FecB mutation were bright green, while wild type (++) samples without FecB were orange yellow. This study suggested that this method has 100% accuracy and 0.5 ng/µL sensitivity. To our knowledge, this is the first report that shows the integration of the ARMS with SYBR Green I to detect FecB expression in sheep visually.
The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study
Authors: Gregoriano Claudia , Koch Daniel , Kutz Alexander , Haubitz Sebastian , Conen Anna , Bernasconi Luca , Hammerer-Lercher Angelika , Saeed Kordo , Mueller Beat , Schuetz Philipp 
Published: January 2021

Abstract

Objectives
Midregional pro-adrenomedullin (MR-proADM) is a vasoactive peptide with key roles in reducing vascular hyperpermeability and thereby improving endothelial stability during infection. While MR-proADM is useful for risk stratification in patients with sepsis, clinical data about prediction accuracy in patients with severe acute respiratory syndrome coronavirus 2 disease (COVID-19) is currently missing.

Methods
We included consecutively adult patients hospitalized for confirmed COVID-19 at a tertiary care center in Switzerland between February and April 2020. We investigated the association of MR-proADM levels with in-hospital mortality in logistic regression and discrimination analyses.

Results
Of 89 included COVID-19 patients, 19% (n=17) died while in the hospital. Median admission MR-proADM levels (nmol/L) were increased almost 1.5-fold increased in non-survivors compared to survivors (1.3 [interquartile range IQR 1.1–2.3]) vs. 0.8 [IQR 0.7–1.1]) and showed good discrimination (area under the curve 0.78). An increase of 1 nmol/L of admission MR-proADM was independently associated with a more than fivefold increase in in-hospital mortality (adjusted odds ratio of 5.5, 95% confidence interval 1.4–21.4, p=0.015). An admission MR-proADM threshold of 0.93 nmol/L showed the best prognostic accuracy for in-hospital mortality with a sensitivity of 93%, a specificity of 60% and a negative predictive value of 97%. Kinetics of follow-up MR-proADM provided further prognostic information for in-hospital treatment.

Conclusions
Increased levels of MR-proADM on admission and during hospital stay were independently associated with in-hospital mortality and may allow a better risk stratification, and particularly rule-out of fatal outcome, in COVID-19 patients.
Semi-kinematic geodetic reference frame based on the ITRF2014 for Malaysia
Authors: Azhari M. , Altamimi Z. , Azman G. , Kadir M. , Simons W.J.F , Sohaime R. , Yunus M.Y. , Irwan M.J. , Asyran C.A. , Soeb N. , Fahmi A. , Saiful A. 
Published: January 2021

Abstract
Malaysia is located at the stable part of the tec-tonic Sundaland platelet in SE Asia. The platelet is surrounded in almost every direction by tectonically active convergent boundaries, at which the Philippine Sea, the Australian and the Indian Plates are subducting respectively from the East, South and West.The current Malaysia geodetic reference frame called MGRF2000 is a static reference frame and hence did not incorporate the effects of plate motion and the ensuing deformation from (megath-rust) earthquakes. To prevent degradation of Continuously Operating Reference Station (CORS) coordinates, a new time-dependent national reference frame was developed. Taking advantage of the availability of the GNSS data of the CORS network in Malaysia, notably the Malaysia Active GPS System (MASS) and Malaysia Real-Time Kinematic GNSS Network (MyRTKnet), a more accurate and robust Malaysian geodetic reference frame was determined, fully aligned and compatible with ITRF2014. The cumulative solution obtained from stacking Malaysian CORS position time series formed the basis of the new MGRF2020 realization. It consists of 100+ station positions at epoch 2020.0, station velocities and Post-Seismic Deformation (PSD) parametric models for stations subjected to major earthquakes. The (1999-2018) position time series exhibit Weighted Mean Root Square (WRMS) values of 3.0, 3.2 and 7.6 mm in respectively the East, North and Vertical components. A new semi-kinematic geodetic datum (GDM2020) for Malaysia, useable for GIS, mapping and cadastre applications is proposed to replace the existing static datum (GDM2000). A transformation suite to convert the spatial databases from GDM2000 to GDM2020 was also developed.
The domination number of round digraphs
Authors: Zhang Xinhong , Xue Caijuan , Li Ruijuan 
Published: January 2021

Abstract
The concept of the domination number plays an important role in both theory and applications of digraphs. Let

D
=
(
V
,
A
)

D=(V,A)

be a digraph. A vertex subset

T
⊆
V
(
D
)

T\subseteq V(D)

is called a dominating set of D, if there is a vertex

t
∈
T

t\in T

such that

t
v
∈
A
(
D
)

tv\in A(D)

for every vertex

v
∈
V
(
D
)
\
T

v\in V(D)\backslash T

. The dominating number of D is the cardinality of a smallest dominating set of D, denoted by

γ
(
D
)

\gamma (D)

. In this paper, the domination number of round digraphs is characterized completely.
MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway
Authors: Zhang Aichun , Jin Yangzi 
Published: January 2021

Abstract
Allergic rhinitis (AR) is one of the most common chronic diseases. This study examined whether microRNA (miR)-182-5p plays a role in AR by regulating toll-like receptor 4 (TLR4). First, data demonstrated that TLR4 was a target of miR-182-5p. Subsequently, AR mouse model was established to explore the role of miR-182-5p and TLR4 in AR in vivo. Initially, quantitative reverse transcription-PCR (qRT-PCR) analysis indicated that miR-182-5p was downregulated, while TLR4 expression was upregulated in AR mice. Then we found that miR-182-5p mimic reduced the frequency of sneezing and nose rubbing of the AR mice. In addition, miR-182-5p mimic significantly increased ovalbumin (OVA)-specific IgE and leukotriene C4 expression levels in nasal lavage fluid (NLF) and serum of AR mice. miR-182-5p mimic decreased the number of inflammatory cells in NLF of AR mice. It also reduced the levels of inflammatory factors in the serum of AR mice, such as interleukin (IL)-4, IL-5, IL-13, IL-17 and tumor necrosis factor (TNF)-α, while increasing the release of IFN-γ and IL-2. Finally, miR-182-5p mimic inhibited NF-κB signaling pathway activation in AR mice. However, all effects of miR-182-5p mimic on AR mice were reversed by TLR4-plasmid. In conclusion, miR-182-5p/TLR4 axis may represent a novel therapeutic target for AR.
Crystal structure of 5,7,7-trimethyl-4,6,7,8-tetrahydrocyclopenta[g]isochromen-1(3H)-one, C15H18O2
Authors: Tian Kaixin , Wang Yanhong , Xun Miaomiao , Yuan Changchun , Fu Kai 
Published: January 2021

Abstract
C15H18O2, monoclinic, P21/n (no. 14), a = 12.7072(5) Å, b = 11.2947(6) Å, c = 17.7857(7) Å, β = 95.807(1)°, V = 2539.6(2) Å3, Z = 8, R

gt
(F) = 0.0606, wR

ref
(F
2) = 0.1759, T = 170 K.
The crystal structure of N-(adamantan-1-yl)-piperidine-1-carbothioamide, C16H26N2S
Authors: Bari Ahmed , Hosten Eric C. , Abdulrahman AlObaid , Usman Ghani 
Published: January 2021

Abstract
C16H26N2S, monoclinic, P21/n (no. 14), a = 6.4855(4) Å, b = 20.1110(12) Å, c = 11.2575(7) Å, β = 92.014(2)°, V = 1467.41(16) Å3, Z = 4, R

gt
(F) = 0.0324, wR

ref
(F
2) = 0.0889, T = 200 K.