bluuebunny/crossref_metadata_2025_split huggingface dataset:
V1 as an egocentric cognitive map
Authors: Linton Paul 
Published: September 2021

AbstractWe typically distinguish between V1 as an egocentric perceptual map and the hippocampus as an allocentric cognitive map. In this article, we argue that V1 also functions as a post-perceptual egocentric cognitive map. We argue that three well-documented functions of V1, namely (i) the estimation of distance, (ii) the estimation of size, and (iii) multisensory integration, are better understood as post-perceptual cognitive inferences. This argument has two important implications. First, we argue that V1 must function as the neural correlates of the visual perception/cognition distinction and suggest how this can be accommodated by V1’s laminar structure. Second, we use this insight to propose a low-level account of visual consciousness in contrast to mid-level accounts (recurrent processing theory; integrated information theory) and higher-level accounts (higher-order thought; global workspace theory). Detection thresholds have been traditionally used to rule out such an approach, but we explain why it is a mistake to equate visibility (and therefore the presence/absence of visual experience) with detection thresholds.
COPII Sec23 proteins form isoform-specific endoplasmic reticulum exit sites with differential effects on polarized growth
Authors: Chang Mingqin , Wu Shu-Zon , Ryken Samantha E , O’Sullivan Jacquelyn E , Bezanilla Magdalena 
Published: September 2021

AbstractCoat Protein complex II (COPII), a coat protein complex that forms vesicles on the endoplasmic reticulum (ER), mediates trafficking to the Golgi. While metazoans have few genes encoding each COPII component, plants have expanded these gene families, leading to the hypothesis that plant COPII has functionally diversified. In the moss Physcomitrium (Physcomitrella) patens, the Sec23/24 gene families are each composed of seven genes. Silencing Sec23/24 revealed isoform-specific contributions to polarized growth, with the closely related Sec23D/E and Sec24C/D essential for protonemal development. Focusing on Sec23, we discovered that Sec23D/E mediate ER-to Golgi transport and are essential for tip growth, with Sec23D localizing to presumptive ER exit sites. In contrast, Sec23A, B, C, F, and G are dispensable and do not quantitatively affect ER-to-Golgi trafficking. However, Δsec23abcfg plants exhibited reduced secretion of plasma membrane cargo. Of the four highly expressed protonemal Sec23 genes, Sec23F/G are members of a divergent Sec23 clade specifically retained in land plants. Notably, Sec23G accumulates on ER-associated foci that are significantly larger, do not overlap with, and are independent of Sec23D. While Sec23D/E form ER exit sites and function as bona fide COPII components essential for tip-growing protonemata, Sec23G and the closely related Sec23F have likely functionally diversified, forming separate and independent ER exit sites and participating in Golgi-independent trafficking pathways.
Duncan Tanner Essay Prize Winner 2020
Authors: Morris George 
Published: September 2021

Abstract
Between 1899 and 1907, the medium Rosalie Thompson—giving voice to her dead daughter, Nelly—participated in a number of experimental seances with the Society for Psychical Research (SPR), which were formative in the development of the society’s theories of telepathy, personality and survival. Using the extensive séance notes taken by the researchers, and the range of published materials related to the case, this article situates psychical research as an intimate practice; its scientific method relied on the production of intimate evidence by the medium, including the intimacy of touch; its leading proponents were neighbours, friends and relatives, who began communicating via Thompson once key members began to die from 1900. By keeping the focus on the life of Thompson herself, however, the article seeks to use the ‘small history’ of Mrs Thompson to tell a bigger and more complex story about intimacy in early twentieth-century Britain.
How and why? Technology and practices used by university mathematics lecturers for emergency remote teaching during the COVID-19 pandemic
Authors: Ní Fhloinn Eabhnat , Fitzmaurice Olivia 
Published: September 2021

AbstractThe COVID-19 pandemic led to closures of university campuses around the world from March 2020 onwards. With little or no time for preparation, lecturers turned to emergency remote teaching to continue to educate their students. Online mathematics education poses particular challenges in terms of both the hardware and software necessary for effective teaching, due to issues with mathematical symbols and notation, among others. In this paper, we report upon an online survey of 257 university mathematics lecturers across 29 countries, which explores what hardware and software they used for emergency remote teaching, for what purposes they used these and what training and support were made available to them at the time. We also consider what approaches they took to emergency remote teaching and what were their reasons for this.
Willingness of Mothers to Receive Reminders for Routine Vaccination Appointments in Northern Nigeria: A Multi-Centre Cross-Sectional Study
Authors: Ibraheem Rasheedat Mobolaji , Bello Afeez Oyesola , Ibrahim Olayinka Rasheed , Garba Bilkisu Ilah , Aliu Rasaki , Abdulkadir Mohammed Baba , Hashim Rabiu , Ibrahim Lawal Magaji , Mohammed Salihu Sheni , Sambo Amina Hannatu , Ahmed Grace , Akintola Moshood Adebayo 
Published: September 2021

AbstractBackgroundRoutine vaccination, a cost-effective means of preventing deadly childhood disease, has a low coverage in Nigeria. The study assessed the willingness of mothers to receive reminder messages for routine vaccination appointments in Northern Nigeria.MethodsA multi-centre cross-sectional study involving at least 363 mother–infant pairs per centre from five states in Northern Nigeria. Data collected include the socio-demographic details, responses on parental phone ownership, mothers’ willingness to receive reminders for immunization appointments and the reminder type characteristics. Data analysis was done with SPSS.ResultsOf the 1952 mother–infant pairs, ownership of at least one household phone was 97.7%. In total, 1613 (82.6%) mothers were willing to receive reminders. A majority (62.2%) of mothers preferred phone calls. A day before the vaccination appointment was the preferred timing (78.1%), and the predominant communication language was the local language for each region.The odds of being willing to receive reminders were 3.1 times, 2.6 times and 1.8 times higher in those with no formal education, primary education and secondary education, respectively, compared with mothers with tertiary education, each p &lt; 0.05. Mothers who delivered at home were significantly less likely to want reminder messages (p = 0.03).ConclusionEight of 10 women in Northern Nigeria are willing to receive a reminder for their child. The predominant mode of reminder preferred is phone calls using the local language. Deployment of mobile phone reminders strategy in Northern Nigeria as a means to improve vaccination uptake is feasible. The institution of this strategy can be in collaboration with service providers.
Optimizing reproductive health management in lupus and Sjogren's syndrome
Authors: Birru Talabi Mehret , Himes Katherine P. , Clowse Megan E.B. 
Published: September 2021

Purpose of review
People with childbearing capacity who are diagnosed with systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS) have specific and important reproductive health considerations.

Recent findings
Recommendations from the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) provide rheumatologists and other clinicians with guidance for reproductive health management of patients with rheumatic diseases. Patient-centered reproductive health counseling can help clinicians to operationalize the EULAR and ACR guidelines and enhance patient care.

Summary
Disease activity monitoring, risk factor stratification, and prescription of pregnancy-compatible medications during pregnancy help to anticipate complications and enhance pregnancy outcomes in SLE and SS. Assisted reproductive technologies are also safe among people with well-controlled disease. Safe and effective contraceptive methods are available for patients with SLE and SS, and pregnancy termination appears to be safe among these patients.
In Vivo Syndesmotic Motion After Rigid and Flexible Fixation Using 4-Dimensional Computerized Tomography
Authors: Wong Murray T. , Wiens Charmaine , LaMothe Jeremy , Edwards W. Brent , Schneider Prism S. 
Published: September 2021

Introduction:
Maintaining reduction after syndesmotic injury is crucial to patient function; however, malreduction remains common. Flexible suture button fixation may allow more physiologic motion of the syndesmosis compared with rigid screw fixation. Conventional syndesmotic imaging fails to account for physiologic syndesmotic motion with ankle range of motion (ROM), providing misleading results. Four-dimensional computerized tomography (4DCT) can image joints through a dynamic ROM. Our purpose was to compare syndesmotic motion after rigid and flexible fixation using 4DCT.

Methods:
We analyzed 13 patients with syndesmotic injury who were randomized to receive rigid (n = 7) or flexible (n = 6) fixation. Patients underwent bilateral ankle 4DCT while moving between ankle dorsiflexion and plantar flexion. Measures of syndesmotic position and rotation were extracted from 4DCT to determine syndesmotic motion as a function of ankle ROM.

Results:
Uninjured ankles demonstrated significant decreases in syndesmotic width of 1.0 mm with ankle plantar flexion (SD = 0.6 mm, P < 0.01). Initial rigid fixation demonstrated reduced motion compared with uninjured ankles in 4 of 5 measures (P < 0.01) despite all patients in the rigid fixation group having removed, loose, or broken screws by the time of imaging. Rigid fixation led to less motion than flexible fixation in 3 measures (P = 0.02–0.04). There were no observed differences in syndesmotic position or motion between flexible fixation and uninjured ankles.

Conclusion:
Despite the loss of fixation in all subjects in the rigid fixation group, initial rigid fixation led to significantly reduced syndesmotic motion. Flexible fixation recreated more physiologic motion compared with rigid fixation and may be used to reduce rates of syndesmotic malreduction.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Strategies for Lynch syndrome identification in selected and unselected gynecological cancers
Authors: Carnevali Ileana , Sahnane Nora , Chiaravalli Anna Maria , Di Lauro Eleonora , Facco Carla , Facchi Sofia , Casarin Jvan , Ghezzi Fabio , Sessa Fausto , Tibiletti Maria Grazia 
Published: September 2021

Background
Endometrial carcinoma represents a sentinel cancer for Lynch syndrome (LS) identification. It is crucial to highlight how other types of tumors can arise in the gynecological tract acting as sentinel tumors in LS patients.
Up to now, no established LS patient management strategy has incorporated the presence of these additional candidate sentinel tumors to improve the prevention and management of LS tumors.

Methods
In order to investigate the involvement of the most frequent gynecological cancers in gynecological cancers, we studied different subsets of gynecological cancers using both somatic approaches, including mismatch repair (MMR) gene immunohistochemical expression, microsatellite instability, and germline analyses ofMSH2, MSH6, MLH1, PMS2 and EPCAM genes.
A total of 261 patients referring to the Cancer Genetic Counselling Service of our institution were included in the study. In detail, our series was composed of 131 patients affected by uterus cancers including endometrial, isthmus and non-HPV endocervical carcinomas, 113 patients affected by ovarian cancers and 17 patients affected by synchronous endometrial/ovarian carcinomas (SEOC).
In addition, we studied 115 cases of endometrial cancers identified by 2 years of universal testing (endometrial cancers/UTs) using IHC analysis of four MMR proteins.

Results and conclusions
The incidence of MMR defective gynecological cancers ranged from 7.1 to 47.1% depending on cancer site and selection. LS patients carriers of pathogenetic MMR variants were identified in 19.8% of uterus cancers, 35.3% of SEOC, 4.4% of ovarian cancers. In addition, pathogenetic MMR variants were identified in 4.3% of endometrial cancers/universal testing investigated with universal screening.
In conclusion, gynecological cancers are heavily involved in LS and our study shows that MMR screening using immunohistochemical pattern and MSI analysis of endometrial and ovarian cancers as well as of rare entities such as non-HPV related endocervical cancers and synchronous endometrial and ovarian cancers are sentinels for LS.
Tumor testing approach improves early identification of MMR defective gynecological cancers and this is an effective strategy to detect high-risk patients and to offer them and their relatives personalized cancer prevention.
Epigenetic clocks in the pediatric population: when and why they tick?
Authors: Wang Jing , Zhou Wen-Hao 
Published: September 2021

Abstract
Recent research efforts have provided compelling evidence of genome-wide DNA methylation alterations in pediatrics. It is currently well established that epigenetic clocks, composed of DNA methylation sites, can estimate the gestational and chronological age of cells and tissues from different ages. Also, extensive research is aimed at their correlation with early life exposure and pediatric diseases. This review aimed to systematically summarize the epigenetic clocks in the pediatric population. Publications were collected from PubMed and Web of Science databases up to Apr 2021. Epigenetic clocks, DNA methylation clocks, epigenetic age acceleration or deceleration, pediatric and the pediatric population were used as search criteria. Here, we first review the currently applicative pediatric epigenetic clocks. We then highlight the interpretation for epigenetic age deviations in the pediatric population and their association with external factors, developmental trajectories, and pediatric diseases. Considering the remaining unknown of pediatric clocks, research strategies into them are also discussed. In all, pediatric epigenetic clocks may act as potent tools to understand development, growth and diseases in early life.
Influencing factors on women's attitudes toward menopause: a systematic review
Authors: Dashti Sareh , Bahri Narjes , Fathi Najafi Tahereh , Amiridelui Masoumeh , Latifnejad Roudsari Robab 
Published: September 2021

Abstract

Importance:
Menopause is a natural stage of the reproductive life of a woman. This natural event might affect activities of daily living and cause problems for women. Positive attitudes toward menopause can improve women's quality of life and reduce the severity of menopausal symptoms.

Objective:
The aim of this systematic review was to assess the factors influencing women's attitudes toward menopause.

Evidence review:
This systematic review was conducted based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guideline in medical databases including PubMed, Web of Science, Scopus and Google Scholar, as well as Magiran, and SID until October 2020.

Findings:
A total of 7,512 articles were identified. Eight articles were included in the review after excluding the duplicates and screening the articles based on the inclusion and exclusion criteria. The majority of the studies used the Attitude Toward Menopause Scale to assess the attitudes toward menopause. This variable differed between the studies conducted in different regions and countries. Furthermore, postmenopausal women had more positive attitudes toward menopause compared with peri- or premenopausal women. Other influencing factors of attitudes toward menopause included age, menopausal symptoms, psychological and socioeconomical status, and profession and ethnicity.

Conclusion and relevance:
The findings showed that menopausal stage, menopausal symptoms, and psychological and socioeconomic status can influence the attitude of women toward menopause. Therefore, these factors should be considered in interventions that aim to improve women's attitudes toward menopause.
Adolescent, Parent, and Provider Perspectives of a Social-Media–Based Support Tool for Parents of Teens in Treatment for Substance Use
Authors: Schulte Marya T. , Kelleghan Annemarie R. 
Published: September 2021

Abstract
Adolescent substance use disorder contributes to negative psychosocial and physical health outcomes. Parents best support their child's treatment and recovery when they are equipped with knowledge and skills; however, barriers hinder parental engagement. Social-media-based groups present an opportunity for parents who may not otherwise seek support. Qualitative data were collected via focus groups to examine the opinions of adolescents, parents, and treatment providers on the potential utility and possible concerns of a Facebook-based parent support group; input constituted the development phase for an online group (PURPOSE). Fifty-eight participants, recruited through adolescent treatment programs, took part in six focus groups: two parent (n = 18), two adolescent (n = 21), and two provider (n = 19) groups. Groups were audio recorded and transcribed, and themes were extracted. Three main themes emerged: (a) traditional support groups and treatment services, (b) PURPOSE intervention content and delivery, and (c) issues related to PURPOSE implementation. Traditional treatment/support groups can be helpful, but participation in them is limited. Emotional support offered by peers is valuable, but parents also need and seek out psychoeducation, parenting skills, and self-care support. PURPOSE could offer easy access to skills and real-time peer support.
Remote patient triage: Shifting toward safer telehealth practice
Authors: Kobeissi Mahrokh M. , Ruppert Susan D. 
Published: September 2021

ABSTRACT
Telehealth is a tool used to diagnose and treat patients at a distance. Telehealth quickly became essential during the COVID-19 pandemic as a result of stay-at-home orders. Regulatory waivers encouraged the use of telehealth as an alternative to the in-person encounter to limit the spread of disease. The pandemic incited a rapid growth in telehealth, and new legislation, new technologies, and providers new to virtual care changed the delivery of traditional telehealth. Postpandemic planning is necessary to support the safe integration of telehealth in the health care system. The purpose of this article is to discuss the current issues affecting telehealth and offer recommendations for safer virtual care. Critical considerations, beginning with an assessment of remote patient acuity, are needed to ensure the standard of care for telehealth is equivalent to the in-person setting. A triage protocol to screen patients seeking virtual services is required to prevent underestimation of severity of illness, sort patients to place of service, and determine if a need exists to escalate to an in-person evaluation or higher level of care. A standard approach to triage may minimize the risks to patient safety and support the appropriate use of telehealth technologies.
Nurses' Intent to Leave their Position and the Profession During the COVID-19 Pandemic
Authors: Raso Rosanne , Fitzpatrick Joyce J. , Masick Kevin 
Published: September 2021

OBJECTIVE
The aim of this study was to describe the relationships between perceptions of the pandemic impact on clinical nurses' and nurse leaders' intent to leave their current position and the profession and the differences in pandemic impact and intent to leave variables based on background factors.

BACKGROUND
There is much discussion and concern about the COVID-19 pandemic impact on nurses' health and the nursing workforce.

METHODS
More than 5000 nurses from a national sample participated in a cross-sectional, descriptive study. Participants rated their perceptions of the pandemic impact on their practice and their intent to leave their position and profession.

RESULTS
Pandemic impact was rated high overall and was highest in nurses with 25+ years of experience and in managers/directors. Eleven percent of the total sample indicated they intended to leave their position, and 20% were undecided. Nurses who rated pandemic impact at the highest level had higher intent to leave their position. Of the respondents, less than 2% indicated they were leaving the nursing profession, whereas 8% were undecided.

CONCLUSIONS
This is the 1st quantitative report of perceived level of pandemic impact on direct care nurses and nurse managers/directors at the time of this writing. The combination of those who intend to leave and those who are uncertain about leaving their positions could cause instability in the workforce if not reversed. Organizational attention to nurse well-being, work environment and staffing is imperative.
A Qualitative Exploration of Chief Nursing Officer Perspectives on Maintaining Magnet® Designation
Authors: Urden Linda D. , Baclig Jannise T. , Sanchez Kimberly 
Published: September 2021

OBJECTIVE
The purpose of this study was to determine chief nursing officer (CNO) perspectives on how to sustain the infrastructure required for successful American Nurses Credentialing Center (ANCC) Magnet® redesignation.

BACKGROUND
American Nurses Credentialing Center Magnet designation is a prestigious achievement reflective of years of dedication, innovation, mentoring, and leadership support. As challenging as the initial attainment of Magnet status can be, sustaining the success and becoming redesignated is considered even more difficult by many CNOs. However, there have been no published reports indicating how to be successful in Magnet redesignation.

METHOD
A grounded theory qualitative approach was used, and data were collected through telephone interviews with CNOs who had successfully attained at least 1 redesignation.

RESULTS
Fourteen CNOs participated; data were organized into 6 themes and 15 subthemes describing the critical elements for Magnet redesignation.

CONCLUSION
Relationships among the 6 themes and subthemes are theorized in the form of a wheel with 6 spokes. When “set in motion,” the wheel gathers momentum and all of the model elements become coalesced into the organizational ethos.
Cartilage Remodeling in Nasal Tip Rhinoplasty Using “Lateral Crural Steal” and “Tongue in Groove” Strategies: A Randomized Controlled Trial
Authors: Gentile Pietro , Cervelli Valerio 
Published: September 2021

Background:
The authors present their experience using “Lateral Crural Steal” (LCS) and “Tongue in Groove” (TING) techniques in nasal tip remodeling.

Objectives:
The paper aimed to evaluate the efficacy and safety of the use of LCS and TING in nasal tip remodeling for aesthetic improvement.

Methods:
A randomized controlled trial was conducted. Thirty-five patients affected by low and boxy nasal tips were treated with LCS and TINGs (study group [SG]), comparing results with the control group (CG) (n = 30) treated with cartilage grafts. The preoperative analysis has been performed with an accurate clinical evaluation, a photographic assessment, and a computed tomography scan. Postoperative follow-up took place at 1, 2, and 4 weeks, 3, 6, and 12 months, and then annually.

Results:
A total of 82.9% (n = 29) of SG patients showed excellent cosmetic and functional results after 1 year compared with the CG patients, who showed the same results in only 40% (n = 12) of cases. The tip projection maintenance and contour restoring in the SG were higher than that in the CG (P < 0.0001 versus CG).

Conclusions:
The use of LCS and TING was safe and effective in this series of cases performed.