bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carotid plaque inflammatory activity assessed by 2-[18F]FDG-PET imaging decrease after a neurological thromboembolic event
Authors: Urbak Laerke , Ripa Rasmus S. , Sandholt Benjamin V. , Kjaer Andreas , Sillesen Henrik , Graebe Martin 
Published: March 2021

Abstract
Background
Atherosclerotic plaque vulnerability is comprised by plaque composition driven by inflammatory activity and these features can be depicted with 3D ultrasound and 2-[18F]FDG-PET, respectively. The study investigated timely changes in carotid artery plaque inflammation and morphology after a thromboembolic event with PET/CT and novel ultrasound volumetric grayscale median (GSM) readings. Patients with a single hemisphere-specific neurological symptom and the presence of an ipsilateral carotid artery atherosclerotic plaque were prospectively included to both 2-[18F]FDG PET/CT and 3D ultrasound scans of the plaque immediately after their event and again three months later. On PET/CT images the maximum standardized uptake value (SUVmax) was measured and the volumetric ultrasound acquisitions were analyzed using a semiautomated software measuring GSM values.

Results
Baseline scans were performed by a mean of 7 days (range 2–14) after the symptom and again after 98 days (range 91–176). For the entire group (n = 14), we found a decrease in average SUVmax from baseline to follow-up of − 0.18 (95% confidence interval: − 0.34 to − 0.02, P = 0.034). GSM did not increase significantly over time (mean change: + 2.21, 95% confidence interval: − 17.02 to 21.44, P = 0.808).

Conclusion
A decrease in culprit lesion 2-[18F]FDG-uptake 3 months after an event indicates a decrease in inflammatory activity, suggesting that carotid plaque stabilization over time. 3D ultrasound morphological quantitative differences in GSM were not detectable after 3 months.
Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody
Authors: Kaneko Yutaro , Hatano Ryo , Hirota Naoto , Isambert Nicolas , Trillet-Lenoir Véronique , You Benoit , Alexandre Jérôme , Zalcman Gérard , Valleix Fanny , Podoll Thomas , Umezawa Yoshimi , Takao Seiichi , Iwata Satoshi , Hosono Osamu , Taguchi Tetsuo , Yamada Taketo , Dang Nam H. , Ohnuma Kei , Angevin Eric , Morimoto Chikao 
Published: March 2021

Abstract
Background
The phase I trial of the humanized anti-CD26 monoclonal antibody YS110 for CD26-expressing tumors was conducted recently. The present study identifies a potential prognostic biomarker for CD26-targeted therapy based on the phase I data.

Methods
Box and Whisker plot analysis, Scatter plot analysis, Peason product moment correlation/Spearman’s rank-difference correlation, Bar graph analysis, and Receiver Operating Characteristics (ROC) were used to examine the correlation between sCD26 titer variation with YS110 administration and tumor volume change, RECIST criteria evaluation and progression free survival (PFS). Mechanism for serum sCD26 titer variation was confirmed by in vitro experimentation.

Results
Serum sCD26/DPP4 titer was reduced following YS110 administration and gradually recovered until the next infusion. Serum sCD26/DPP4 titer before the next infusion was sustained at lower levels in Stable Disease (SD) cases compared to Progressive Disease cases. ROC analysis defined the cut-off level of serum sCD26/DPP4 titer variation at day 29 pre/post for the clinical outcome of SD as tumor response or PFS. In vitro experimentation confirmed that YS110 addition reduced sCD26 production from CD26-expressing tumor and non-tumor cells.

Conclusions
Our study indicates that serum sCD26/DPP4 titer variation in the early phase of YS110 treatment is a predictive biomarker for evaluating therapeutic efficacy.
NGSS-based teacher professional development to implement engineering practices in STEM instruction
Authors: Christian Kimberly B. , Kelly Angela M. , Bugallo Mónica F. 
Published: March 2021

AbstractBackgroundWith widespread adoption of the Next Generation Science Standards (NGSS) in the USA (US), research is needed on how secondary science, technology, engineering, and mathematics (STEM) teachers conceptualize the integration of engineering knowledge and practices in traditional STEM classrooms. The present study explored the affective impacts of participation in an engineering education workshop for secondary STEM teachers as part of a 200-h professional development program. The workshop focused on the implementation of electrical engineering and biotechnology principles and design practices in disciplinary instruction, as well as training teachers to differentiate among engineering fields and advise on career pathways. The conceptual framework for the workshop design was based upon elements of the interconnected model of professional growth to identify influences contributing to engineering pedagogical self-efficacy and career awareness.ResultsThe overarching research questions addressed how professional development in engineering education affected secondary STEM teachers’ beliefs about the value of using engineering design to support learning, their self-efficacy regarding teaching engineering in their courses, perceived obstacles to effective STEM integration, and their confidence advising students about engineering post-secondary study and careers. The convergent parallel mixed methods design involved factor analysis, comparisons of means, and phenomenology with elements of grounded theory. The survey sample included 60 STEM teachers in the treatment group and 28 teachers in the control group. Six science teachers participated in interviews before and after the engineering workshops. Findings indicated that participating teachers significantly improved their confidence in engineering pedagogy, as well as their knowledge of engineering careers and precollege preparation for post-secondary engineering. Teachers expressed their views of engineering as a potentially powerful tool in developing students’ critical thinking and problem-solving skills, particularly when integrating the practices of science and engineering with the instruction of disciplinary content.ConclusionsThe results from this study demonstrate that a university-based professional development workshop series, developed by engineering and science education faculty, is an effective first-step intervention to improve the engineering knowledge and skills of secondary STEM educators, ultimately facilitating NGSS adoption in classroom instruction. Educating teachers on engineering career pathways is another innovation for the promotion of more diverse participation in engineering fields.
Multiple sclerosis patients and COVID-19
Authors: Mado Hubert , Adamczyk-Sowa Monika 
Published: March 2021

AbstractCoronavirus disease 2019 (COVID-19) is now a major issue for all fields of medicine. Due to the higher mortality rate among patients with chronic diseases, it has also caused concern in patients with multiple sclerosis (MS), who in addition are often receiving immunosuppressive drugs. The aim of this article is to discuss what is currently known about the severity of COVID-19 in MS patients.
Vulvar lipoma: So giant and rare?
Authors: Büyüközsoy Ayşegül Karadayı , Aydıner Ömer 
Published: March 2021

Abstract
Background
Lipomas are often small tumors and rarely reach a size larger than 2 cm. Vulvar lipoma is a rare tumor localization, and only a few cases have been reported. It is important to distinguish lipomas from other vulvar masses like liposarcomas, Nuck canal cyst, Bartholin’s cyst, and inguinal hernias.

Case presentation
We report on a case of a 43-year-old woman who presented with a giant left vulvar mass and discuss the magnetic resonance imaging (MRI) results.

Conclusions
MRI is useful in evaluating vulvar lipomas and differentiating them from other vulvar pathologies.
The effect of anaesthetic dose on response and remission in electroconvulsive therapy for major depressive disorder: nationwide register-based cohort study
Authors: Kronsell Alexander , Nordenskjöld Axel , Bell Max , Amin Ridwanul , Mittendorfer-Rutz Ellenor , Tiger Mikael 
Published: March 2021

Background
Electroconvulsive therapy (ECT) is a safe and effective treatment for major depressive disorder (MDD). ECT treatment effect relies on induced generalised seizures. Most anaesthetics raise the seizure threshold and shorten seizure duration. There are no conclusive studies on the effect of anaesthetic dose on response and remission rates with ECT for MDD.

Aims
We aimed to examine the effect of different dose intervals of anaesthetics on response and remission after ECT for MDD.

Method
We conducted a nationwide cohort study, using data from Swedish registers. Low-, medium- and high-dose intervals, adjusted for age and gender, were constructed for each anaesthetic drug. Response and remission were measured with the Clinical Global Impression – Severity and Improvement scales (CGI-I and CGI-S), and a self-rated version of the Montgomery–Åsberg Depression Rating Scale (MADRS-S). Logistic regression models were used to calculate adjusted odds ratios for response and remission rates.

Results
The study included 7917 patients who received ECT for MDD during 2012–2018. Patients were given either thiopental (64.1%) or propofol (35.9%). Low-dose intervals of anaesthetics were associated with increased rates of response (CGI-I: odds ratio 1.22, 95% CI 1.07–1.40, P = 0.004; MADRS-S: odds ratio 1.31, 95% CI 1.09–1.56, P = 0.004) and remission (CGI-S: odds ratio 1.37, 95% CI 1.17–1.60, P ≤ 0.001; MADRS-S: odds ratio 1.31, 95% CI 1.10–1.54, P = 0.002).

Conclusions
We found improved treatment outcomes with low- compared with high-dose anaesthetic during ECT for MDD. To enhance treatment effect, deep anaesthesia during ECT for MDD should be avoided.
Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium
Authors: Beyer Jörg , Collette Laurence , Sauvé Nicolas , Daugaard Gedske , Feldman Darren R. , Tandstad Torgrim , Tryakin Alexey , Stahl Olof , Gonzalez-Billalabeitia Enrique , De Giorgi Ugo , Culine Stéphane , de Wit Ronald , Hansen Aaron R. , Bebek Marko , Terbuch Angelika , Albany Costantine , Hentrich Marcus , Gietema Jourik A. , Negaard Helene , Huddart Robert A. , Lorch Anja , Cafferty Fay H. , Heng Daniel Y. C. , Sweeney Christopher J. , Winquist Eric , Chovanec Michal , Fankhauser Christian , Stark Daniel , Grimison Peter , Necchi Andrea , Tran Ben , Heidenreich Axel , Shamash Jonathan , Sternberg Cora N. , Vaughn David J. , Duran Ignacio , Bokemeyer Carsten , Patrikidou Anna , Cathomas Richard , Assele Samson , Gillessen Silke ,   for the International Germ Cell Cancer Classification Update Consortium
Published: March 2021

PURPOSE The classification of the International Germ-Cell Cancer Collaborative Group (IGCCCG) has been a major advance in the management of germ-cell tumors, but relies on data of only 660 patients with seminoma treated between 1975 and 1990. We re-evaluated this classification in a database from a large international consortium. MATERIALS AND METHODS Data on 2,451 men with metastatic seminoma treated with cisplatin- and etoposide-based first-line chemotherapy between 1990 and 2013 were collected from 30 institutions or collaborative groups in Australia, Europe, and North America. Clinical trial and registry data were included. Primary end points were progression-free survival (PFS) and overall survival (OS) calculated from day 1 of treatment. Variables at initial presentation were evaluated for their prognostic impact. Results were validated in an independent validation set of 764 additional patients. RESULTS Compared with the initial IGCCCG classification, in our modern series, 5-year PFS improved from 82% to 89% (95% CI, 87 to 90) and 5-year OS from 86% to 95% (95% CI, 94 to 96) in good prognosis, and from 67% to 79% (95% CI, 70 to 85) and 72% to 88% (95% CI, 80 to 93) in intermediate prognosis patients. Lactate dehydrogenase (LDH) proved to be an additional adverse prognostic factor. Good prognosis patients with LDH above 2.5× upper limit of normal had a 3-year PFS of 80% (95% CI, 75 to 84) and a 3-year OS of 92% (95% CI, 88 to 95) versus 92% (95% CI, 90 to 94) and 97% (95% CI, 96 to 98) in the group with lower LDH. CONCLUSION PFS and OS in metastatic seminoma significantly improved in our modern series compared with the original data. The original IGCCCG classification retains its relevance, but can be further refined by adding LDH at a cutoff of 2.5× upper limit of normal as an additional adverse prognostic factor.
Multiparty quantum communication protocol based on quantum stabilizer codes with identity authentication
Authors: Li J. X. , He Z. X. , Zhao S. , Yan D. D. , Ma H. Y. 
Published: March 2021

Abstract
Quantum communication has been extensively studied and continuously developed due to its theoretical absolute security. In this work, a novel multiparty quantum communication protocol based on quantum stabilizer codes (QSC) is proposed. Firstly, a trusted third party provides quantum identity authentication (QIA) for users. Secondly, users prepare quantum multiparticle entangled states for transmitting secret information. Thirdly, the secret information is encoded by the QSC to resist channel noise. A part of the encoded qubits is selected to detect the security of the communication. In this protocol, QIA prevents active attacks such as impersonation attacks; the physical laws of quantum entangled state ensure information security; the theory of QSC corrects the flipping errors of qubits, and improves the communication efficiency. In addition, we prove the security of the protocol, and further verify the communication efficiency. Compared with existing protocols, this protocol has better performance on communication efficiency.
19-hydroxy Steroids in the Aromatase Reaction: Review on Expression and Potential Functions
Authors: Abaffy Tatjana , Matsunami Hiroaki 
Published: March 2021

Abstract
Scientific evidence related to the aromatase reaction in various biological processes spanning from mid-1960 to today is abundant; however, as our analytical sensitivity increases, a new look at the old chemical reaction is necessary. Here, we review an irreversible aromatase reaction from the substrate androstenedione. It proceeds in 3 consecutive steps. In the first 2 steps, 19-hydroxy steroids are produced. In the third step, estrone is produced. They can dissociate from the enzyme complex and either accumulate in tissues or enter the blood.
In this review, we want to highlight the potential importance of these 19-hydroxy steroids in various physiological and pathological conditions. We focus primarily on 19-hydroxy steroids, and in particular on the 19-hydroxyandrostenedione produced by the incomplete aromatase reaction. Using a PubMed database and the search term “aromatase reaction,” 19-hydroxylation of androgens and steroid measurements, we detail the chemistry of the aromatase reaction and list previous and current methods used to measure 19-hydroxy steroids.
We present evidence of the existence of 19-hydroxy steroids in brain tissue, ovaries, testes, adrenal glands, prostate cancer, as well as during pregnancy and parturition and in Cushing’s disease. Based on the available literature, a potential involvement of 19-hydroxy steroids in the brain differentiation process, sperm motility, ovarian function, and hypertension is suggested and warrants future research.
We hope that with the advancement of highly specific and sensitive analytical methods, future research into 19-hydroxy steroids will be encouraged, as much remains to be learned and discovered.
Tyrosine sulfation and O-glycosylation of chemoattractant receptor GPR15 differentially regulate interaction with GPR15L
Authors: Okamoto Yukari , Shikano Sojin 
Published: March 2021

ABSTRACTGPR15 is a G-protein-coupled receptor (GPCR) that directs lymphocyte homing to the colon and skin. Recent studies have identified a chemokine-like protein GPR15L (also known as C10orf99) as a functional ligand of GPR15. In this study, we examined the structural elements that regulate the GPR15–GPR15L interaction with primary focus on post-translational modifications (PTMs) of receptor N-terminus and on the C-terminus of the ligand. Our findings reveal that the GPR15 receptor is sulfated on the N-terminal tyrosine residue(s) and disruption of tyrosine sulfation inhibits binding of GPR15L. In contrast, the disruption of O-glycosylation on the N-terminal threonine or serine residues, or the removal of α2,3-linked sialic acids from O-glycans, enhances the GPR15L binding. Thus, GPR15 represents a unique chemoattractant receptor in which different N-terminal PTMs regulate its ligand binding in a contrasting manner. We further demonstrate that, unlike canonical chemokines, GPR15L activity critically requires its extreme C-terminal residue and that its hydrophobicity may be a key attribute that facilitates an optimal interaction with the receptor. Our results reveal novel insights into chemoattractant receptor–ligand interaction and provide a valid footing for potential intervention targeting the GPR15–GPR15L axis.
AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer
Authors: Li Wanyun , Liu Cong , Huang Zilan , Shi Lei , Zhong Chuanqi , Zhou Wenwen , Meng Peipei , Li Zhenyu , Wang Shengyu , Luo Fanghong , Yan Jianghua , Wu Ting 
Published: March 2021

ABSTRACT
Autophagy is considered to be an important switch for facilitating normal to malignant cell transformation during colorectal cancer development. Consistent with other reports, we found that the membrane receptor Neuropilin1 (NRP1) is greatly upregulated in colon cancer cells that underwent autophagy upon glucose deprivation. However, the mechanism underlying NRP1 regulation of autophagy is unknown. We found that knockdown of NRP1 inhibits autophagy and largely upregulates the expression of aldo-keto reductase family 1 B10 (AKR1B10). Moreover, we demonstrated that AKR1B10 interacts with and inhibits the nuclear importation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and then subsequently represses autophagy. Interestingly, we also found that an NADPH-dependent reduction reaction could be induced when AKR1B10 interacts with GAPDH, and the reductase activity of AKR1B10 is important for its repression of autophagy. Together, our findings unravel a novel mechanism of NRP1 in regulating autophagy through AKR1B10.
Lie detection in the brain - Moral, social, legal and religious challenges
Authors: Poulou Chrysa G 
Published: March 2021

Lie detection and recognition has been an ardent human desire since ancient times. Over the centuries, various methods have been devised to detect fraud. Some methods are low-tech, like the recognition of specialized facial expressions, while others use devices, such as the polygraph or "lie detector" designed in the early 20th century, which measure changes in human body like sweating, heart rate and blood pressure, in order to detect the lie. These methods have various applications in areas such as justice, the military and the secret services. Recent attempts to detect falsehood have focused on measuring brain activity. This approach, unlike previous emotional arousal methods, detects physiological changes associated with cognitive processes during deception and therefore, according to the proponents of the technique, could detect the process of deception itself. The most well-known method of detecting a "neurophysiological difference between deception and truth" in the brain is functional Magnetic Resonance Imaging (fMRI), an MRI brain scan which reveals that deception is located in the prefrontal cortex, just behind the forehead.However, how accurate and reliable are these “brain mapping” approaches to detect lies? What are the moral, legal, religious and social issues arising from the “invasion” of so-called neuroscience into personal data, individual freedom, and the right of non-self-incrimination and the "free will" of human beings? Critical questions, addressed in this paper, in an attempt to approach lie detection in the brain and the challenges - concerns that may determine the way we perceive human society in the future.
Population attributable risk for colorectal and breast cancer in England, Wales, Scotland, Northern Ireland, and the United Kingdom
Authors: Goon Shatabdi , Kim Hanseul , Giovannucci Edward L. 
Published: March 2021

Background: The population attributable risk (PAR) is a statistic commonly used for quantifying preventability of cancer. We report here PAR estimates for the United Kingdom (UK) along with its constituent countries for up-to-date risk factor-attributable colorectal cancer (CRC) and breast cancer (BC), focusing on diet and nutrition related factors and tobacco (CRC) using representative national surveys. Methods: The PAR was calculated using established, modifiable risk factors by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR): physical activity, body mass index (BMI), alcoholic drinks, red meat, processed meat, dietary fiber, dietary calcium, as well as cigarette smoking for CRC, and physical activity, BMI, alcoholic drinks, and fruits and vegetable consumption for BC. National prevalence estimates and relative risks (RRs) for CRC and BC were obtained from meta-analyses or large pooled analyses. Results: Based on eight dietary and lifestyle risk factors, the estimates for attributable cases of CRC for males and females, respectively, were as follows: England: 67% and 60%; Scotland: 68% and 59%, Wales: 66% and 61%; Northern Ireland: 67% and 61%; and UK: 67% and 60%. Excluding smoking, the PAR for the UK was 61% for men and 52% for women. Based on four dietary and lifestyle risk factors, the estimates for BC were as follows: England: 26%, Scotland: 27%; Wales: 25%; Northern Ireland: 26%; and UK: 27%. Conclusion: Up to 67% for CRC and 27% of BC were attributable to modifiable dietary and lifestyle factors in the UK. Moderate differences in PAR are observed between countries due to different prevalence of exposure to risk factors.
All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes
Authors: Hughes Alice E. , Hayes M. Geoffrey , Egan Aoife M. , Patel Kashyap A. , Scholtens Denise M. , Lowe Lynn P. , Lowe Jr William L. , Dunne Fidelma P. , Hattersley Andrew T. , Freathy Rachel M. 
Published: March 2021

Background: Using genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational diabetes (GDM) have different implications for genetic susceptibility to raised fasting glucose and type 2 diabetes in women from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) and Atlantic Diabetes in Pregnancy (DIP) studies. Methods: Cases were divided into three subgroups: (i) FPG ≥5.1 mmol/L only, n=222; (ii) 1-hour glucose post 75 g oral glucose load ≥10 mmol/L only, n=154 (iii) 2-hour glucose ≥8.5 mmol/L only, n=73; and (iv) both FPG ≥5.1 mmol/L and either of a 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, n=172. We compared the FPG and T2D GS of these groups with controls (n=3,091) in HAPO and DIP separately. Results: In HAPO and DIP, the mean FPG GS in women with a FPG ≥5.1 mmol/L, either on its own or with 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, was higher than controls (all P <0.01). Mean T2D GS in women with a raised FPG alone or with either a raised 1-hour or 2-hour glucose was higher than controls (all P <0.05). GDM defined by 1-hour or 2-hour hyperglycaemia only was also associated with a higher T2D GS than controls (all P <0.05). Conclusions: The different diagnostic categories that are part of the WHO 2013 criteria for GDM identify women with a genetic predisposition to type 2 diabetes as well as a risk for adverse pregnancy outcomes.