bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of automated audit and feedback on data completeness in the electronic health record of the general physician: protocol for a cluster randomized controlled trial
Authors: Van den Bulck Steve , De Burghgraeve Tine , Raat Willem , Mamouris Pavlos , Coursier Patrick , Vankrunkelsven Patrik , Goderis Geert , Hermens Rosella , Van Pottelbergh Gijs , Vaes Bert 
Published: May 2021

Abstract
Background
The electronic health record (EHR) of the general physician (GP) is an important tool that can be used to assess and improve the quality of healthcare. However, there are some problems when (re) using the data gathered in the EHR for quality assessments. One problem is the lack of data completeness in the EHR. Audit and feedback (A&F) is a well-known quality intervention that can improve the quality of healthcare. We hypothesize that an automated A&F intervention can be adapted to improve the data completeness of the EHR of the GP, more specifically, the number of correctly registered diagnoses of type 2 diabetes and chronic kidney disease.

Methods
This study is a pragmatic cluster randomized controlled trial with an intervention at the level of GP practice. The intervention consists of an audit and extended electronically delivered feedback with multiple components that will be delivered 4 times electronically to general practices over 12 months. The data will be analyzed on an aggregated level (per GP practice). The primary outcome is the percentage of correctly registered diagnoses of type 2 diabetes. The key secondary outcome is the registration of chronic kidney disease. Exploratory secondary outcomes are the registration of heart failure, biometric data and lifestyle habits, and the evolution of 4 different EHR-extractable quality indicators.

Discussion
This cluster randomized controlled trial intends to primarily improve the registration of type 2 diabetes in the EHR of the GP and to secondarily improve the registration of chronic kidney disease. In addition, the registration of heart failure, lifestyle parameters, and biometric data in the EHR of the GP are explored together with 4 EHR-extractable quality indicators. By doing so, this study aims to improve the data completeness of the EHR, paving the way for future quality assessments.

Trial registration
ClinicalTrials.gov NCT04388228. Registered on May 14, 2020.
Single-cell sequencing of the small and AT-skewed genome of malaria parasites
Authors: Liu Shiwei , Huckaby Adam C. , Brown Audrey C. , Moore Christopher C. , Burbulis Ian , McConnell Michael J. , Güler Jennifer L. 
Published: May 2021

AbstractSingle-cell genomics is a rapidly advancing field; however, most techniques are designed for mammalian cells. We present a single-cell sequencing pipeline for an intracellular parasite, Plasmodium falciparum, with a small genome of extreme base content. Through optimization of a quasi-linear amplification method, we target the parasite genome over contaminants and generate coverage levels allowing detection of minor genetic variants. This work, as well as efforts that build on these findings, will enable detection of parasite heterogeneity contributing to P. falciparum adaptation. Furthermore, this study provides a framework for optimizing single-cell amplification and variant analysis in challenging genomes.
Existence and multiplicity of solutions for Kirchhof-type problems with Sobolev–Hardy critical exponent
Authors: Fan Hongsen , Deng Zhiying 
Published: May 2021

AbstractIn this paper, we discuss a class of Kirchhof-type elliptic boundary value problem with Sobolev–Hardy critical exponent and apply the variational method to obtain one positive solution and two nontrivial solutions to the problem under certain conditions.
Percolation-Based Image Processing for the Plastic Viscosity of Cementitious Mortar with Super Absorbent Polymer
Authors: Aryanfar Asghar , Şanal Irem , Marian Jaime 
Published: May 2021

AbstractSuper absorbent polymers (SAP) are the recent promising chemical admixtures with the potential for reducing the shrinkage, cracking, freeze/thaw and increasing the durability of the concrete. These polymers are classified as hydrogels when cross-linked and can retain exceptionally high amount of liquid solutions of their own weight. In this paper, the flowability of the concrete is quantified by means of developing a percolation-based image processing method and the transient behavior of the viscosity of the SAP-contained mortar mixture is characterized via numerical solution of Navier–Stokes relationship. In addition, rheological measurements and the analytical development has been carried out for complementary verification of the viscosity trends. Controlling the flow within such relatively short period of time is essential for tuning the functionality of concrete during the construction as well as it’s respective resilience during the extended period of application.
From information experiences to consumer engagement on brand’s social media accounts
Authors: Park Jee-Sun , Ha Sejin 
Published: May 2021

AbstractThe purpose of this paper is to propose and empirically validate a model that explains user experiences with information interactions on fashion brand pages, leading to consumer engagement on social media. Specifically, this study tests whether values involved in information interactions prompt positive emotions, which in turn foster experiential states contributing to customer engagement intentions. The moderating role of curiosity is also examined. Data from 290 users of fashion brand page in South Korea were collected using a web-based survey method. Structural equation modeling and the PROCESS macro were used to test the research hypotheses. The results revealed that the perceived values involved in information interactions (usefulness, enjoyment) elicit positive emotions, which foster experiential states (satisfaction, cognitive engagement, elaboration) that lead to engagement intentions with brand pages. The results also showed the moderating effect of curiosity on the relationship between perceived values and positive emotions. Theoretical and practical contributions are discussed.
Consumer store experience through virtual reality: its effect on emotional states and perceived store attractiveness
Authors: Jin Byoungho , Kim Gwia , Moore Marguerite , Rothenberg Lori 
Published: May 2021

AbstractBased on the stimuli-organism-response model, this study aims to examine whether consumers’ store experience through virtual reality (VR), compared to website experience, can attract them enough to perceive the online store as appealing. Two types of stimuli were developed for the experiments: consumers’ VR store experience (106 data) (i.e., having respondents experience 360-degree-based VR store videos recorded at a fashion retailer) and store website experience (107 data) (i.e., having respondents experience the same store’s website). The results revealed that relative to an ordinary store website, consumers’ VR store experience evoked positive emotions and increased perceived store attractiveness. This study also discovered that store familiarity does not moderate the relationship between the two store experience types and evoked emotions, implying that VR technology is effective regardless of consumers’ familiarity with a store. Text analytics were also utilized, providing additional insights about their VR store experiences. This study suggests an effective method for online retailers to emulate an attractive store environment and entice consumers through VR, regardless of the retailers’ fame. Specifically, it demonstrates the effectiveness of VR over website in enhancing store attractiveness, an under-studied area.
National Trends in Pediatric Admissions for Diabetic Ketoacidosis, 2006–2016
Authors: Everett Estelle M , Copeland Timothy P , Moin Tannaz , Wisk Lauren E 
Published: May 2021

Abstract

Background and Objectives
Diabetic ketoacidosis (DKA) rates in the United States are rising. Prior studies suggest higher rates in younger populations, but no studies have evaluated national trends in pediatric populations and differences by subgroups. As such, we sought to examine national trends in pediatric DKA.

Methods
We used the 2006, 2009, 2012, and 2016 Kids’ Inpatient Database to identify pediatric DKA admissions among a nationally representative sample of admissions of youth ≤20 years old. We estimate DKA admission per 10 000 admissions and per 10 000 population, charges, length of stay (LOS), and trends over time among all hospitalizations and by demographic subgroups. Regression models were used to evaluate differences in DKA rates within subgroups overtime.

Results
Between 2006 and 2016, there were 149 535 admissions for DKA. Unadjusted DKA rate per admission increased from 120.5 (95% CI, 115.9-125.2) in 2006 to 217.7 (95% CI, 208.3-227.5) in 2016. The mean charge per admission increased from $14 548 (95% CI, $13 971-$15 125) in 2006 to $20 997 (95% CI, $19 973-$22 022) in 2016, whereas mean LOS decreased from 2.51 (95% CI, 2.45-2.57) to 2.28 (95% CI, 2.23-2.33) days. Higher DKA rates occurred among 18- to 20-year-old females, Black youth, without private insurance, with lower incomes, and from nonurban areas. Young adults, men, those without private insurance, and from nonurban areas had greater increases in DKA rates across time.

Conclusions
Pediatric DKA admissions have risen by 40% in the United States and vulnerable subgroups remain at highest risk. Further studies should characterize the challenges experienced by these groups to inform interventions to mitigate their DKA risk and to address the rising DKA rates nationally.
Peptide Receptor Radionuclide Therapy With 177Lu-DOTATATE for Symptomatic Control of Refractory Carcinoid Syndrome
Authors: Zandee Wouter T , Brabander Tessa , Blažević Anela , Minczeles Noémie S , Feelders Richard A , de Herder Wouter W , Hofland Johannes 
Published: May 2021

Abstract

Context
Peptide receptor radionuclide therapy (PRRT) with [Lutetium-177-DOTA0-Tyr3]octreotate (177Lu-DOTATATE) results in an increase of progression-free survival and quality of life in patients with progressive, well-differentiated neuroendocrine neoplasms (NENs).

Objective
To study the effect of 177Lu-DOTATATE in patients with carcinoid syndrome and radiologically stable or newly diagnosed disease treated solely for the purpose of symptom reduction.

Design
Retrospective cohort study.

Setting
Tertiary care hospital.

Patients
Twenty-two patients with a metastatic midgut NEN, elevated urinary 5-hydroxyindolacetic acid excretion, and flushing and/or diarrhea despite treatment with a somatostatin analog, without documented disease progression.

Intervention
PRRT with 177Lu-DOTATATE (intended cumulative dose: 29.6 GBq) with a primary aim to reduce symptoms.

Results
After PRRT, mean bowel movement frequency (BMF) decreased from 6.1 ± 3.4 to 4.6 ± 3.6 per day (P = 0.009). Flushes decreased from 4.3 ± 2.9 to 2.4 ± 2.7 flushes per day (P = 0.002). A decrease of BMF of more than 30% occurred in 47% of patients with baseline BMF of 4 or more (n = 17). In patients with ≥2 episodes of flushing a day (n = 15), 67% of patients had more than 50% decrease of daily flushing. A decrease in urinary 5-hydroxyindolacetic acid excretion of more than 30% was seen in 56% of patients. The European Organization for Research and Treatment of Cancer–Core Module diarrhea subscale score showed a trend toward improvement by an average of 16.7 ± 33.3 points (P = 0.11).

Conclusion
PRRT with 177Lu-DOTATATE effectively reduced diarrhea and flushing in patients with carcinoid syndrome and can be considered for symptomatic treatment of carcinoid syndrome insufficiently controlled with somatostatin analogs.
“Did Emmett Till Die in Vain? Organized Labor Says No!”: The United Packinghouse Workers and Civil Rights Unionism in the Mid-1950s
Authors: Nichter Matthew F. 
Published: May 2021

Abstract
Emmett Till's mangled face is seared into our collective memory, a tragic epitome of the brutal violence that upheld white supremacy in the Jim Crow South. But Till's murder was more than just a tragedy: it also inspired an outpouring of protest, in which labor unions played a prominent role. The United Packinghouse Workers of America (UPWA) campaigned energetically, from the stockyards of Chicago to the sugar refineries of Louisiana. The UPWA organized the first mass meeting addressed by Till's mother, Mamie Bradley; packinghouse workers petitioned, marched, and rallied to demand justice; and an interracial group of union activists traveled to Mississippi to observe the trial of Till's killers firsthand, flouting segregation inside and outside the courtroom. Analysis of antiracist unions like the UPWA can help rectify a weakness in the “whiteness” literature by illuminating the contexts and strategies that have fostered durable interracial working-class solidarity. The UPWA, which managed to survive the Red Scare of the late 1940s and early 1950s relatively unscathed, represents an important link between the “civil rights unionism” of the 1930s and 1940s and the civil rights movement of the mid-1950s and 1960s.
The biomechanical basis of biased epithelial tube elongation in lung and kidney development
Authors: Conrad Lisa , Runser Steve Vincent Maurice , Fernando Gómez Harold , Lang Christine Michaela , Dumond Mathilde Sabine , Sapala Aleksandra , Schaumann Laura , Michos Odyssé , Vetter Roman , Iber Dagmar 
Published: May 2021

ABSTRACT
During lung development, epithelial branches expand preferentially in a longitudinal direction. This bias in outgrowth has been linked to a bias in cell shape and in the cell division plane. How this bias arises is unknown. Here, we show that biased epithelial outgrowth occurs independent of the surrounding mesenchyme, of preferential turnover of the extracellular matrix at the bud tips and of FGF signalling. There is also no evidence for actin-rich filopodia at the bud tips. Rather, we find epithelial tubes to be collapsed during early lung and kidney development, and we observe fluid flow in the narrow tubes. By simulating the measured fluid flow inside segmented narrow epithelial tubes, we show that the shear stress levels on the apical surface are sufficient to explain the reported bias in cell shape and outgrowth. We use a cell-based vertex model to confirm that apical shear forces, unlike constricting forces, can give rise to both the observed bias in cell shapes and tube elongation. We conclude that shear stress may be a more general driver of biased tube elongation beyond its established role in angiogenesis.
This article has an associated ‘The people behind the papers’ interview.
Lewis Wolpert (1929-2021)
Authors: Smith J. C. 
Published: May 2021

ABSTRACT
Lewis Wolpert, who died on 28 January 2021, was an inspirational figure to generations of developmental biologists, and a man whose influence extended far beyond his subject. By seeing significance in the commonplace, and by identifying and re-framing research questions, he inspired new ways of thinking about embryonic development. As a teacher and as a lecturer he was nonpareil, and his ideas were brilliantly distilled in his textbook Principles of Development, which will continue to imbue students with his clarity of thought. In writing about his depression, Wolpert reduced the stigma associated with the disease and provided scientific understanding, solace and hope. An open, kind and generous man, he went out of his way to support young scientists.
Sickness behaviors across vertebrate taxa: proximate and ultimate mechanisms
Authors: Lopes Patricia C. , French Susannah S. , Woodhams Douglas C. , Binning Sandra A. 
Published: May 2021

ABSTRACT
There is nothing like a pandemic to get the world thinking about how infectious diseases affect individual behavior. In this respect, sick animals can behave in ways that are dramatically different from healthy animals: altered social interactions and changes to patterns of eating and drinking are all hallmarks of sickness. As a result, behavioral changes associated with inflammatory responses (i.e. sickness behaviors) have important implications for disease spread by affecting contacts with others and with common resources, including water and/or sleeping sites. In this Review, we summarize the behavioral modifications, including changes to thermoregulatory behaviors, known to occur in vertebrates during infection, with an emphasis on non-mammalian taxa, which have historically received less attention. We then outline and discuss our current understanding of the changes in physiology associated with the production of these behaviors and highlight areas where more research is needed, including an exploration of individual and sex differences in the acute phase response and a greater understanding of the ecophysiological implications of sickness behaviors for disease at the population level.
Opposing effects of dopamine on agonistic behaviour in crayfish
Authors: Ibuchi Kengo , Nagayama Toshiki 
Published: May 2021

ABSTRACTThe effects of dopamine on the agonistic behaviour of crayfish were analysed. When dopamine concentrations of 1 μmol l−1 were injected into large crayfish, individuals were beaten by smaller opponents, despite their physical advantage. Injection of 10 μmol l−1 dopamine into small animals increased their rate of winning against larger opponents. Injection of a D1 receptor antagonist prohibited the onset of a ‘loser’ effect in subordinate animals, suggesting that the inhibitory effect of dopamine on larger animals is mediated by D1 receptors. Similarly, injection of a D2 receptor antagonist prohibited the onset of a ‘winner’ effect in dominant animals, suggesting that the facilitating effect of dopamine on small animals is mediated by D2 receptors. Since the inhibitory effect of 1 μmol l−1 dopamine was similar to that seen with 1 μmol l−1 octopamine and the facilitating effect of 10 μmol l−1 dopamine was similar to that of 1 μmol l−1 serotonin, functional interactions among dopamine, octopamine and serotonin were analyzed by co-injection of amines with their receptor antagonists in various combinations. The inhibitory effect of 1 μmol l−1 dopamine disappeared when administered with D1 receptor antagonist, but remained when combined with octopamine receptor antagonist. Octopamine effects disappeared when administered with either D1 receptor antagonist or octopamine receptor antagonist, suggesting that the dopamine system is downstream of octopamine. The facilitating effect of 10 μmol l−1 dopamine disappeared when combined with serotonin 5HT1 receptor antagonist or D2 receptor antagonist. Serotonin effects also disappeared when combined with D2 receptor antagonist, suggesting that dopamine and serotonin activate each other through parallel pathways.
Development of a Map of HR Trends and Technologies
Authors: Bushueva I. , Andreeva E. , Kryukova A. 
Published: May 2021

Currently, the emergence and development of technologies, including in personnel management, is happening at an exponential speed. The use of modern HR trends and technologies allows organizations to meet the requirements of the time. Despite a significant number of studies of trends in HR and related forecasts, this information requires generalization, structuring and visual presentation.
Presented in the article «Map of HR trends and technologies» gives an idea of the development directions of existing and future HR trends and technologies for the period 2020-2040. The developed map presents the development path of the role of an HR specialist, as well as trends in the main areas of HR activity: personnel management, personnel development, recruitment, HR branding, working environment. The map defines three time periods corresponding to the development horizons - near, middle and far.
The practical value of using the developed HR trend map lies in its usability, logic and structure of the presented information, as well as the content of a large number of the most relevant HR areas in modern organizations.
Posterior oblique ligament of the knee: state of the art
Authors: D’Ambrosi Riccardo , Corona Katia , Guerra Germano , Cerciello Simone , Ursino Chiara , Ursino Nicola , Hantes Michael 
Published: May 2021

The posterior oblique ligament (POL) is the predominant ligamentous structure on the posterior medial corner of the knee joint. A thorough understanding of the anatomy, biomechanics, diagnosis, treatment and rehabilitation of POL injuries will aid orthopaedic surgeons in the management of these injuries. The resulting rotational instability, in addition to valgus laxity, may not be tolerated by athletes participating in pivoting sports. The most common mechanism of injury – accounting for 72% of cases – is related to sports activity, particularly football, basketball and skiing. Moreover, three different injury patterns have been reported: those associated with injury to the capsular arm of the semimembranosus (SM), those involving a complete peripheral meniscal detachment and those involving disruption of the SM and peripheral meniscal detachment. The hallmark of an injury related to POL lesions is the presence of anteromedial rotatory instability (AMRI), which is defined as ‘external rotation with anterior subluxation of the medial tibial plateau relative to the distal femur’. In acute settings, POL lesions can be easily identified using coronal and axial magnetic resonance imaging (MRI) where the medial collateral ligament (MCL) and POL appear as separate structures. However, MRI is not sensitive in chronic cases. Surgical treatment of the medial side leads to satisfactory clinical results in a multi-ligamentous reconstruction scenario, but it is known to be associated with secondary stiffness. In young patients with high functional demands, return to sports is allowed no earlier than 9–12 months after they have undergone a thorough rehabilitation programme. Cite this article: EFORT Open Rev 2021;6:364-371. DOI: 10.1302/2058-5241.6.200127
Azolla microphylla and Pseudomonas aeruginosa for bioremediation of bioethanol wastewater
Authors: Annisa Khoirul , SUTARNO SUTARNO , SANTOSA SLAMET 
Published: May 2021

Abstract. Annisa K, Sutarno, Santosa S. 2021. Azolla microphylla and Pseudomonas aeruginosa for bioremediation of bioethanol wastewater. Biodiversitas 22: 1799-1805. Bioremediation is the right choice in wastewater treatment since it requires has low cost but works optimally. Azolla microphylla and Pseudomonas aeruginosa are considered to have the ability to optimize waste degradation. The aim of this study was to determine the best treatment for reducing pollutants in bioethanol waste, namely by using A. microphylla and P. aeruginosa. The twelve treatments in this experimental research included variations in the A. microphylla biomass and variations of biomass combinations with the density of the P. aeruginosa. Research method used was completely randomized design with three replications, and all 36 samples were taken on the seventh day. Research data collected were the quality parameters of bioethanol wastewater before and after the treatment. The results showed that TSS, BOD, COD were decreased during seven days of treatment, whereas pH and H2S levels were increased. The combination of 0.2 kg A. microphylla and 1010 cfu/mL P. aeruginosa showed the best result in reducing pollutants. This study showed that A. microphylla and P. aeruginosa could be used to reduce pollutants in bioethanol wastewater. Results of the research are expected to become an alternative solution to the bioethanol wastewater problem.