bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Cardiac Safety and Survival Outcomes of Neoadjuvant Pegylated Liposomal Doxorubicin in Elderly Patients or Prone to Cardiotoxicity and Triple Negative Breast Cancer. Final Results of the Multicentre Phase II CAPRICE Study
Authors: Gil-Gil Miguel J. , Bellet Meritxell , Bergamino Milana , Morales Serafín , Barnadas Agustí , Manso Luís , Saura Cristina , Fernández-Ortega Adela , Garcia-Martinez Elena , Martinez-Jañez Noelia , Melé Mireia , Villagrasa Patricia , Celiz Pamela , Perez Martin X. , Ciruelos Eva , Pernas Sonia 
Published: July 2021

BackgroundThe CAPRICE trial was designed to specifically evaluate neoadjuvant pegylated liposomal doxorubicin (PLD) in elderly patients or in those with other cardiovascular risk factors in whom conventional doxorubicin was contraindicated. The primary analysis of the study showed a pathological complete response (pCR) of 32% and no significant decreases in LVEF during chemotherapy. Here, we report important secondary study objectives: 5-year cardiac safety, disease-free survival (DFS), overall survival (OS) and breast cancer specific survival (BCSS).MethodsIn this multicentre, single-arm, phase II trial, elderly patients or those prone to cardiotoxicity and high risk stage II-IIIB breast cancer received PLD (35 mg/m2) plus cyclophosphamide (600 mg/m2) every 4 weeks for 4 cycles, followed by paclitaxel for 12 weeks as neoadjuvant chemotherapy (NAC). Left ventricular ejection fraction (LVEF) monitorization, electrocardiograms and cardiac questionnaires were performed at baseline, during treatment and at 9, 16, 28 and 40 weeks thereafter. The primary endpoint was pCR and 5-year cardiac safety, DFS, BCSS and OS were also analyzed.ResultsBetween Oct 2007, and Jun 2010, 50 eligible patients were included. Median age was 73 (35-84) years, 84% were older than 65; 64% of patients suffered from hypertension, and 10% had prior cardiac disease. Most of tumors (88%) were triple negative. No significant decreases in LVEF were observed. The mean baseline LVEF was 66.6% (52-86) and after a median follow-up of 5 years, mean LVEF was 66 (54.5-73). For intention to treat population, 5-year DFS was 50% (95% CI 40.2-68.1) and 5-year OS was 56% (95%CI 41.2-68.4). There were 8 non-cancer related deaths, achieving a 5 years BCSS of 67.74% (CI 95%:54.31%- 81.18%).ConclusionAt 5-year follow-up, this PLD-based NAC regimen continued to be cardiac-safe and effective in a population of very high-risk breast cancer patients. This scheme should be considered as an option in elderly patients or in those with other risks of developing cardiotoxicity.Trial Registration NumberClinicalTrials.gov reference NCT00563953.
Development of a Nomogram Based on Preoperative Bi-Parametric MRI and Blood Indices for the Differentiation Between Cystic-Solid Pituitary Adenoma and Craniopharyngioma
Authors: Zhao Zhen , Xiao Dongdong , Nie Chuansheng , Zhang Hao , Jiang Xiaobing , Jecha Ali Rajab , Yan Pengfei , Zhao Hongyang 
Published: July 2021

BackgroundGiven the similarities in clinical manifestations of cystic-solid pituitary adenomas (CS-PAs) and craniopharyngiomas (CPs), this study aims to establish and validate a nomogram based on preoperative imaging features and blood indices to differentiate between CS-PAs and CPs.MethodsA departmental database was searched to identify patients who had undergone tumor resection between January 2012 and December 2020, and those diagnosed with CS-PAs or CPs by histopathology were included. Preoperative magnetic resonance imaging (MRI) features as well as blood indices were retrieved and analyzed. Radiological features were extracted from the tumor on contrast-enhanced T1 (CE-T1) weighted and T2 weighted sequences. The two independent samples t-test and principal component analysis (PCA) were used for feature selection, data dimension reduction, and radiomics signature building. Next, the radiomics signature was put in five classification models for exploring the best classifier with superior identification performance. Multivariate logistic regression analysis was then used to establish a radiomic-clinical model containing radiomics and hematological features, and the model was presented as a nomogram. The performance of the radiomics-clinical model was assessed by calibration curve, clinical effectiveness as well as internal validation.ResultsA total of 272 patients were included in this study: 201 with CS-PAs and 71 with CPs. These patients were randomized into training set (n=182) and test set (n=90). The radiomics signature, which consisted of 18 features after dimensionality reduction, showed superior discrimination performance in 5 different classification models. The area under the curve (AUC) values of the training set and the test set obtained by the radiomics signature are 0.92 and 0.88 in the logistic regression model, 0.90 and 0.85 in the Ridge classifier, 0.88 and 0.82 in the stochastic gradient descent (SGD) classifier, 0.78 and 0.85 in the linear support vector classification (Linear SVC), 0.93 and 0.86 in the multilayers perceptron (MLP) classifier, respectively. The predictive factors of the nomogram included radiomic signature, age, WBC count, and FIB. The nomogram showed good discrimination performance (with an AUC of 0.93 in the training set and 0.90 in the test set) and good calibration. Moreover, decision curve analysis (DCA) demonstrated satisfactory clinical effectiveness of the proposed radiomic-clinical nomogram.ConclusionsA personalized nomogram containing radiomics signature and blood indices was proposed in this study. This nomogram is simple yet effective in differentiating between CS-PAs and CPs and thus can be used in routine clinical practice.
Effect of a Topical Nonsteroidal Anti-Inflammatory Drug (0.1% Pranoprofen) on VEGF and COX-2 Expression in Primary Pterygium
Authors: Yao Bangtao , Wang Fei , Zhao Xiaogui , Wang Bei , Yue Xiaoli , Ding Yuhua , Liu Gang 
Published: July 2021

Purpose:To evaluate the effect of a topical nonsteroidal anti-inflammatory drug (0.1% pranoprofen) on the expression of VEGF and Cox-2 in primary pterygium.Methods:This was a prospective, randomized study. Between January 2019 and April 2020, 120 patients diagnosed with primary pterygium were enrolled and randomly divided into three groups before operation: 1) 40 patients in group 1 received topical pranoprofen 0.1% four times daily for 4 weeks, 2) 40 patients in group 2 received topical fluorometholone 0.1% four times daily for 4 weeks, and 3) patients in group 3 did not receive treatment. For each group, the age, sex, eye type, best-corrected visual acuity (BCVA), intraocular pressure (IOP), duration of onset, combined systemic diseases, and the results regarding vascular endothelial growth factor (VEGF) and cyclo-oxygen-ase-2 (COX-2) in postoperative pterygial tissues were evaluated in detail.Results:There were no significant differences regarding age, sex, eye type, combined systemic diseases, duration of onset, IOP, and BCVA within the three groups (p&gt; 0.05). The reduction of VEGF and CoX-2 expression of pterygial vascular endothelial cells in group 1 were statistically significant compared to group 2 and group 3 (p&lt; 0.05). There were significant correlations between COX-2 and VEGF expression of pterygial tissues within the three groups (p&lt; 0.05).Conclusion:The present findings suggested that the topical pranoprofen 0.1% could reduce the expression of VEGF and COX-2 in primary pterygium. We confirmed that treatment with pranoprofen offers advantages in early intervention and has therapeutic potential in reducing the postoperative recurrence of primary pterygium patients.Clinical Trial registration: The study was registered with the Chinese Clinical Trial Registry. (http://www.chictr.org.cn/index.aspx, Registration Number: ChiCTR2100047726).
Sustainable Scheduling of the Production in the Aluminum Furnace Hot Rolling Section with Uncertain Demand
Authors: Huang Yiping , Yang Qin , Liu Jinfeng , Li Xiao , Zhang Jie 
Published: July 2021

In order to reduce the energy consumption of furnaces and save costs in the product delivery time, the focus of this paper is to discuss the uncertainty of demand in the rolling horizon and to globally optimize the sustainability of the production in the aluminum furnace hot rolling section in environmental and economic dimensions. First, the triples α/β/γ are used to describe the production scheduling in the aluminum furnace hot rolling section as the scheduling of flexible flow shop, satisfied to constraints of demand uncertainty, operation logic, operation time, capacity and demand, objectives of minimizing the residence time of the ingot in the furnace and minimizing the makespan. Second, on the basis of describing the uncertainty of demand in rolling horizon with the scenario tree, a multi-objective mixed integer linear programming (MILP) optimization model for sustainable production in the aluminum furnace hot rolling section is formulated. Finally, an aluminum alloy manufacturer is taken as an example to illustrate the proposed model. The computational results show that when the objective weight combination takes the value of α=0.7, β=0.3, the sustainability indicators of the environmental and economic dimensions can be optimized to the maximum extent possible at the same time. Increasingly, managerial suggestions associated with the trade-off between environmental and economic dimensions are presented. Scheduling in the rolling horizon can optimize the production process of the aluminum furnace hot rolling section globally, indicating that it is more conducive to the sustainable development of the environment and economic dimensions than scheduling in a single decision time period.
Comparative characteristics of analysis methods of the corporate social responsibility management
Authors: Nadeyko Mykola 
Published: July 2021

The purpose of the article is to form the theoretical foundations of the state (level) analysis of social responsibility for the enterprise management needs. The study used identification, systematization and analysis of the advantages and disadvantages of existing methods, which made it possible to identify methodological recommendations for improving of social responsibility process. It was characterized the state of assessing the social responsibility of national enterprises at the level of Ukrainian rating agencies over the past five years. Leading enterprises in the field of corporate social responsibility have been identified based on the results of national ratings. The existing methods of corporate social responsibility management analysis were analyzed. Their content and methods used in them are identified. The main factors for evaluation are summarized. The expediency of assessing the effectiveness of management by external and internal vectors of social responsibility is noted. The activities aimed at introducing an effective social responsibility management system are presented. For practical usage we have proposed the list of measures that will contribute to the implementation of an effective management system of social responsibility, increase its level and develop this process. As a result of the ratings analysis at the country level, the trends of changes occurring both in the social responsibility management system and in terms of covering information on its implementation are generalized. The conducted studies allow us to conclude that today there is no universal methodology for assessing the level of social responsibility. In this regard, the management of social responsibility of the enterprise was offered to use the advantages of various methods to form its own comprehensive methodology, taking into account management needs and target audience. Therefore, the social responsibility management of the enterprise was offered to use advantages of various methods to form its own comprehensive methodology, taking into account management needs and target audience.
Prospects for development of inbound tourism in Ukraine with using of digital marketing tools
Authors: Nazarenko Olga 
Published: July 2021

The article considers the issues of theory and practice of digital marketing to solve the problems of the tourism business. It is shown that the use of online marketing tools is a necessary condition for the successful development of tourism enterprises. The current state, problems and prospects of development of tourist services market of Ukraine are analyzed. It was found that the priority directions are the development of both inbound and domestic tourism, which are important factors in improving of life quality in Ukraine, creating additional jobs, replenishing the foreign exchange reserves of the state and improving the brand image of Ukraine in the international arena. It has been determined that the strategy of inbound tourism development should provide for the use of a structural and functional method that allows combining various components of the tourism industry and its infrastructure. The main problems that hinder the development of the tourism industry in the country and require further solutions are considered. It is proved that it is possible to stimulate the development of inbound tourism possibly by improving the information and technical infrastructure, improving the service quality, and development of international tourist routes. According to the results of the study, it is proposed ways to increase the subscriber base, create valuable and relevant content for customers, personalize communication with customers and automate this process, as well as formulate recommendations for turning a new customer into a loyal one. It is proved that there are all prerequisites for the tourism sphere development in Ukraine, since Ukraine has significant recreational potential: favorable geographical location, favorable climatic conditions, varied relief, an extensive transport network and preserved monuments of cultural heritage.
Factores de riesgo asociados con alteraciones respiratorias clínicas, espirométricas y radiográficas a seis meses de seguimiento en pacientes con nueva influenza A(H1N1)
Authors: Grajeda-Ancca Pablo 
Published: July 2021

Introducción. En 2009, en la Región Cusco se reportaron 395 casos confirmados de nueva influenza A(H1N1) –NIAH1N1–, 15 defunciones, con alta tasa de letalidad (3,8 %). Los efectos posteriores al cuadro agudo son los temas menos investigados, aunque es importante estudiar la presencia de disfunción respiratoria a seis meses de seguimiento. Objetivo. Determinar los factores de riesgo asociados (FRA) a la presencia y características de las alteraciones respiratorias clínicas, espirométricas y radiográficas al sexto mes de seguimiento en sujetos con antecedente e infección por la NIAH1N1. Métodos. Estudio de corte transversal, en 118 pacientes mayores de 14 años, seis meses después de haber tenido un cuadro de NIAH1N1, confirmado por PCRrt, sin antecedente de afección pulmonar previa en 2009. Resultados. Casi 7 de cada 10 sujetos presentó lguna alteración, las espirométrica y clínica fueron las más frecuentes. La patología de riesgo asociada (RP = 4,11 [IC95% = 2,49-6,78], p = 0,0000002), la demora en el inicio del tratamiento antiviral específico (RP = 4,56 [IC95% = 2,48- 8,37], p = 0,0000001) y la presencia de insuficiencia respiratoria aguda grave (IRAG) (RP = 11,35 [IC95% = 4,27- 30,17], p = 0,0000000) son FRA a alteraciones clínicas; la patología de riesgo asociada (RP = 12,52 [IC95% = 2,7-58,08], p = 0,00003), un FRA a alteración radiográfica; la presencia de IRAG (RP = 1,33 [IC95% = 1,02-1,74], p = 0,04), un FRA a alteración espirométrica. Conclusiones. La NIAH1N1 produce alteraciones clínicas, espirométricas y radiográficas a seis meses de presentado el cuadro agudo, y los FRA son patología de riesgo asociada, demora en el inicio del tratamiento antiviral específico y presencia de IRAG, que deben ser considerados para el tratamiento apropiado, y realizar el seguimiento respectivo y prevenir estas alteraciones.
Evaluación de la eficacia y seguridad del ácido hialurónico por vía oral asociado con glucosamina sulfato, condroitín sulfato y metilsulfonilmetano comparado con la asociación por vía oral de glucosamina sulfato, condroitín sulfato ymetilsulfonilmetano en la osteoartritis de rodilla
Authors: Castañeda Oswaldo , Kuroiwa Rita , Torres David , Castañeda Alejandra , Manche-Kuroiwa Sandra , Priori Ennio 
Published: July 2021

Objetivo. Comparar la eficacia y la seguridad de la asociación de ácido hialurónico (AH), glucosamina sulfato (GS), condroitina sulfato (CS) y metilsulfonilmetano (MSM) versus GS, CS y MSM en el control de los síntomas de la osteoartritis (OA) de rodilla. Material y método. Estudio comparativo, aleatorizado prospectivo, a doble ciego, en pacientes con OA de rodilla, divididos en dos grupos, durante tres meses de tratamiento diario, vía oral. El grupo 1 recibió AH 120 mg + GS 1 500 mg + CS 1 200 mg + MSM 1 000 mg y el grupo 2, la misma asociación pero sin AH. Se incluyeron hombres y mujeres mayores de 40 años y menores de 80 años con diagnóstico de OA de rodilla, según el criterio modificado del Colegio Americano Reumatología (ACR). Se realizaron cuatro evaluaciones, inicial y a las 4, 8 y 12 semanas de tratamiento. El dolor se evalúo con la escala de WOMAC 3.1 y la escala visual análoga (EVA) y el estado de salud, con el cuestionario SF-36 versión 2. En todas las visitas se proporcionó al paciente un formulario para que anote la presencia de algún evento adverso. Resultados. Los grupos 1 y 2 tuvieron similares datos en edad, género, grado de instrucción y tiempo de enfermedad, sin diferencia estadística significativa. Todos los pacientes cumplieron con los criterios del ACR. El grupo 1 tuvo mejores puntajes con diferencia estadísticamente significativa en la variable EVA entre todos los grupos en la semana 12 y en la variable SF-36 en la semana 12. Conclusiones. Se puede concluir que la asociación GS-CS-MSM-AH por vía oral sería más eficaz de igual seguridad que la asociación GS-CS-MSM en el control de los síntomas de la OA de rodilla.
Dexametasona versus dimenhidrinato en la profilaxis de las náuseas y vómitos postoperatorios en pacientes adultos sometidos a cirugía general y digestiva
Authors: Shiraishi-Zapata Carlos 
Published: July 2021

Introducción. Las náuseas y vómitos postoperatorios (NVPO) son complicaciones frecuentes en los pacientes quirúrgicos. Se han publicado una serie de guías clínicas y revisiones que recomiendan diferentes fármacos para la profilaxis y tratamiento de NVPO. Los fármacos dexametasona (DEX) y dimenhidrinato (DIM) son ampliamente utilizados para este fin; sin embargo, la evidencia científica que apoya la efectividad del DIM en el contexto de NVPO, es escasa. Objetivo. Determinarla dosis del fármaco (DIM o DEX con mayor efectividad en la profilaxis de náuseas y vómitos postoperatorios en pacientes adultos sometidos a cirugía general y laparoscópica. Asimismo, determinar la aparición de náuseas, vómitos, náuseas y vómitos postoperatorios, necesidad de tratamiento de rescate y efectos adversos de ambos medicamentos. Material y método. Ensayo clínico aleatorizado realizado en el Hospital II EsSalud de Talara, Piura, Perú con 102 participantes (18 hombres y 84 mujeres) con un riesgo bajo y moderado para NVPO (09 y 93 respectivamente), los que fueron asignados en dos grupos de 51 pacientes cada uno. Un grupo de pacientes recibió DEX (4 mg) y otro DIM (50 mg) luego de la inducción de la anestesia general. Resultados. La incidencia de NVPO en la población tratada con DEX fue de 7,84% y de 39,22% en la población de pacientes que recibieron DIM. Conclusiones. La administración de 4 mg de dexametasona en el acto anestésico provee mejor profilaxis de náuseas y vómitos postoperatorios respecto a 50 mg de dimenhidrinato.
Conceptual and cognitive field of prevention of deviant behavior in departmental universities
Authors: Mescheryakova Elena 
Published: July 2021

The actual problem of preventing departmental university graduates’ deviant behavior, whose professional activity is particularly important for society and the state, is analyzed in the aspect of cadets’ valuable and meaningful dominants formation in the process of moral education, aimed at their professional identity development and professional marginalisation prevention.
The research problem relevance is determined by need to resolve conflicts continued in modern conditions of anomie, especially for professional communities of servicemen and law enforcement agencies. In addition, the importance of the research problem is explained by the fact that many aspects are not elaborated in national psychological and pedagogical research.
In order to prevent deviant behavior in the educational process of departmental institutions, the author proposes the pedagogical technology of formation of valuable and meaningful dominants, which is implemented in cadets’ moral education and ensures their professional identity development and prevention of its antipode – professional marginalization.
The article presents refined concepts of “professional identity”, “professional marginalization”. Moral education characteristic, implemented in line with cadets’ personal development in departmental institutions’ educational process is given. Pedagogical technology of education content and structure, methodological approaches to its development are described.
On the basis of conducted research, directions for further development of studied problem are proposed: holistic concept substantiation of cadets’ moral education in line with the formation of valuable and meaningful dominants of departmental institutions graduates’ professional activity; identification and testing of pedagogical conditions that ensure prevention of deviant behavior; methodological support development for pedagogical technology implementation, taking into account the latest pedagogical science and practice achievements; selection of methods and tools for diagnosing the formation of valuable and meaningful dominants of cadets and assessing the dynamics of their professional identity formation at various stages of pedagogical technology of education implementation.
Deviant behavior of employees of internal affairs bodies: experience of dialectical assessment
Authors: Milyukov Sergey , Nikulenko Andrey 
Published: July 2021

In modern Russia, the problem of countering socially dangerous manifestations acts as a national project that proclaims the right of citizens to safe living conditions. Much attention is paid to the ability of law enforcement officers to resist criminal expansion legally, to be able to protect themselves and others by means of legal use of force against persons who commit socially dangerous encroachments. Guided by the concept of deviance, the authors made an attempt to analyze the problem of lawful behavior by law enforcement officers, primarily police officers. The researchers came to a reasonable conclusion about the need to adjust the current state of affairs. The legislation and the practice of its application cannot satisfy the interests of representatives of law enforcement agencies engaged in official activities for the protection of public order and ensuring of public safety. Imperfect legislation is the main reason of deviant behavior of police officers who are in permanent stress situations. Their abundance also provokes deviant behavior of police officers, which sometimes manifests itself in extreme brutality
towards lawbreakers.
From our point of view, the current norms of the Criminal Code of the Russian Federation, primarily the norms of Chapter 8, are not clear enough. Moreover, their legislative wording is far from being perfect and gives the opportunity to shift the blame for causing harm to persons who do it in circumstances that exclude the criminality of the act.
The proposed careful adjustment of the norms of criminal legislation will significantly increase the effectiveness of their practical implementation, instill confidence in the consciousness of police officers about the importance and possibility of offensive legitimate steps to influence crime, as well as to increase their legal protection.