bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the Roof Slope on the Cost Variation of Residential Houses
Authors: Mbereyaho Leopold , Minani Doris Daniella Dusabe , Niyonshuti Alain , Nsenga Yvan Coppens 
Published: April 2021

Abstract
The building industry has been one of the fast-growing sectors in Rwanda, and multiple residential houses with amazing pitched roofs are being implemented in different cities. As the country is very hilly, the influence of wind loads on the buildings is high and therefore the selection step of roof slopes needs to be carefully undertaken, in order to ensure not only the structure safety, but also the economy. Available international and national guidelines give details about safety and functionality requirements, but don’t talk much about economic aspect, and this was the purpose of the given study. Using a well elaborated methodology, the influence of the roof slope on its cost was checked, and it was established that the slope’s increase of one degree would raise the roof cost by 3.6%. Therefore, during the roof slope selection and design process, economic requirements need more attention.
Cross‐regulation between CDK and MAPK control cellular fate
Authors: Durandau Eric , Pelet Serge 
Published: April 2021

BackgroundCommitment to a new cell cycle is controlled by a number of cellular signals. Mitogen‐activated protein kinase (MAPK) pathways, which transduce multiple extracellular cues, have been shown to be interconnected with the cell cycle and can modulate its progression.MethodsIn budding yeast, we have introduced fluorescent biosensors that monitor in real time the signaling activity of the MAPKs Fus3 and Kss1 and the cyclin‐dependent kinase (CDK) in individual cells. We have quantified in hundreds of live single cells the interplay between the MAPKs regulating the mating response and the CDK controlling cell cycle progression.ResultsDifferent patterns of MAPK activity dynamics could be identified by clustering cells based on their CDK activity, denoting the tight relationship between these two cellular signals. Our data suggest that beyond the already well‐established mechanisms of regulation between the MAPK and the CDK, additional mechanisms remain to be identified.ConclusionA tight interplay between MAPK pathways and the cell cycle is essential to control cellular proliferation and cell fate decisions.
Evolution of folate content during barley malt production
Authors: Koren D. , Hegyesné Vecseri B. , Kun-Farkas G. 
Published: April 2021

AbstractThe aim of this research was to study the effect of micro- and industrial scale malting on the folate content of barley. Two malting barley varieties (one spring and one winter) were studied, applying the same technology. Furthermore, a roasting experiment was carried out at given temperatures for different time periods. The total folate content was determined by microbiological method. The folate content of the barleys was between 10.1 and 23.4 µg/100 g dry matter. For micro- and industrial scale, malting folate content increased 6.5–8-fold and 4–7-fold, respectively, during the malting process. An unexpected result was observed during industrial malting: the folate content increased during kilning by 18–35%, unlike micro scale malting, where a 15–20% decrease was observed. Results obtained during roasting showed that folic acid content did not decrease when roasted for 20 min at 100 °C, but it decreased linearly with increasing temperature. Folate is completely degraded in 20 min at 200 °C. It can be stated that barley malt can serve as a relatively good source of folate, but barley variety and malting technology have significant impact on it.
Bleeding disorders in girls and women: setting the scene
Authors: Skouw-Rasmussen Naja , Lavin Michelle , Ven Minette van der 
Published: April 2021

Abstract
The prevalence and impact of bleeding disorders in women is not sufficiently acknowledged, with the organisation of care traditionally biased towards boys and men with haemophilia. In 2017, the European Haemophilia Consortium surveyed women with bleeding disorders, national member organisations (NMOs) and treatment centres to assess the impact of bleeding disorders in women in four domains: physical activity, active life, romantic and social life, and reproductive life. Most women had von Willebrand disease (VWD) or described themselves as a carrier. All reported a negative impact on physical activity, active life and romantic and social life. Up to 70% of women in all groups reported that their bleeding disorder had a significant impact on their ability or willingness to have children, or prevented it. Heavy menstrual bleeding was reported as the having the most significant impact on daily life. Women face barriers to diagnosis and care, including difficulty obtaining a referral and lack of knowledge among general practitioners and gynaecologists. While bleeding disorders share many symptoms, including bleeding after minor injury and trauma, the link between heavy menstrual bleeding and a bleeding disorder often goes unrecognised and its severity is underestimated. Screening is not offered to all eligible women despite the availability of long-established management guidelines; clinical tools to estimate severity may be unreliable. Failure to recognise a bleeding disorder in a woman is a multifactorial problem that is partly due to cultural reluctance to discuss menstruation. Public awareness campaigns are seeking to correct this, and many NMOs involve women in their initiatives and provide women-centred activities. However, a transformation in diagnosis is needed to shift the focus of treatment centres beyond boys and men with haemophilia, and to acknowledge the prevalence and severity of bleeding disorders in women.
Genetics 101: understanding transmission and genetic testing of inherited bleeding disorders
Authors: Biguzzi Eugenia , Galen Karin van , Kadir Rezan A 
Published: April 2021

Abstract
Haemophilia is an X-linked inherited disorder that affects males and females, though the bleeding risk in girls and women has traditionally been under-recognised. About one third of haemophilia cases occur in individuals where there is no known family history. The gene mutations for rare bleeding disorders are not carried on the X chromosome and are therefore not sex-linked; however, the risk of passing on the condition is greatly increased for consanguineous parents where both parents may carry a copy of the fault in the genetic code which causes the condition. Genetic testing should be offered to every prospective mother, ideally before conception. This should be supported by counselling as the implications for family planning are profound.
Von Willebrand factor (VWF) has an important role in primary and secondary haemostasis. Loss of function or low levels of VWF are associated with spontaneous bleeding causing nosebleeds, heavy periods and bruising as well as jpost-surgical bleeding. Joint bleeding and intracranial haemorrhage can also occur in those with a severe type of VWF. Diagnosis depends on bleeding assessment, family history and measurement of VWF. There are three types of VWD: Types 1 and 3 are caused by low or absent levels of VWD; Type 2 is caused by loss of function. Of these, Type 3 VWD is associated with the most severe bleeding risk but there is wide variation in bleeding phenotype among the other sub-types. The correlation between genetic mutation and bleeding phenotype is weak in VWD; therefore genetic testing is mainly useful for interpreting the risk when planning a family and to allow prenatal diagnosis in severe bleeding disorders.
Genetic testing is essential for prospective parents to make fully informed decisions about having a family and how or whether to proceed with a pregnancy. The rationale for prenatal testing is to determine the bleeding status of the foetus and to inform decisions about managing delivery. Women may choose to terminate a pregnancy to avoid having a child with severe haemophilia. For some couples the option of adoption or not having children may be explored. Options for prenatal diagnostic testing include non-invasive methods, e.g. assessment of free foetal DNA in maternal plasma to determine the sex of a baby from 10 weeks in pregnancy, and invasive methods, e.g. chorionic villus sampling or amniocentesis, to determine the inheritance of the genetic mutation. Invasive methods are associated with a very small increased risk of pregnancy loss or early labour, which many couples feel is an unacceptable risk. Advanced techniques such as preimplantation screening also available, but require a huge commitment as this involves an IVF technique.
Gynaecological issues in women with bleeding disorders: CSL Behring Symposium
Authors: Batorova Angelika , Galen Karin van , Mackensen Sylvia von , Tsimpanakos Ioannis , Grimberg Evelyn 
Published: April 2021

Abstract
The symposium focused on issues around surgery, ovulation bleeding, health-related quality of life (HRQoL) and pelvic pain in women with bleeding disorders.

Surgery
Young women with congenital bleeding disorders, especially those with severe forms, are more likely to experience gynaecological and obstetric disorders than unaffected women. Surgery may be required to manage heavy menstrual bleeding (HMB), ovulatory bleeding, endometriosis and delivery. Major surgery should be undertaken only in hospitals with a haemophilia centre and 24-hour laboratory capability. Correction of haemostasis, either by desmopressin, coagulation factor or platelet transfusion, is essential for a successful outcome of surgery. Management of pregnancy requires a multidisciplinary approach; the mode of delivery is based on the consensus of gynaecologist and haematologist, and with respect to the patient’s diagnosis.

Ovulation bleeding
Women with bleeding disorders are at risk for excessive gynaecological bleeding associated with menstruation, ovulation, pregnancy and delivery. Ovulation bleeding is associated with the rupture of ovarian cysts and causes abdominal pain; complications include haemoperitoneum, fertility problems and ovarian torsion. Management includes hormonal and haemostatic therapies, in combination if necessary, and surgery as a last resort. Current management is based on experience in a relatively small number of cases and more clinical data are needed.

Health-related quality of life
In addition to experiencing joint and tissue bleeds, women experience psychosocial and medical issues associated with menstruation, pregnancy, labour and delivery. HMB has the greatest impact, and is associated with impaired HRQoL in almost all and dissatisfaction with the burden of treatment. There is a need for focused psychosocial support and a specific tool for the assessment of HRQoL in women with bleeding disorders.

Pelvic pain
Gynaecological causes of pelvic pain in women with bleeding disorders include dysmenorrhoea, mid-cycle pain, bleeding into the corpus luteum and endometriosis. There is no correlation between bleeding tendency and endometriosis severity; however, screening for a bleeding disorder should be considered. Pharmacological management may be hormonal or non-hormonal. Gonadotrophin-releasing hormone agonists offer an alternative to surgery for women with severe bleeding disorders who have endometriosis. Paracetamol is the preferred early analgesic option. Endometrial ablation controls heavy bleeding and pelvic pain but is not recommended for women with large fibroids or a large endometrial cavity. Hysterectomy is an option of last resort. Education for health professionals should include raising awareness about the management of pain in women with bleeding disorders.
Perfil epidemiológico dos casos com microcefalia atendidos em maternidade de alto risco em Sergipe
Authors: Almeida Andria Silveira , Da Silva Elaine Ferreira , Figueredo Rodrigues dos Santos Ravena dias , Fontes Almeida Thaynara , Kelly Fraga Oliveira Fernanda , Melo Prado Lourivânia Oliveira 
Published: April 2021

OBJETIVO: Delinear o perfil epidemiológico dos casos atendidos com microcefalia em uma maternidade de alto risco no estado de Sergipe no ano de 2015. MATERIAIS E MÉTODOS: Trata-se de um estudo descritivo quantitativo dos casos de microcefalia em nascidos vivos de mães residentes no estado de Sergipe. Foi desenvolvido em uma maternidade pública de referência para gestantes e recém-nascidos de alto risco do município de Aracaju - Sergipe. A amostra selecionada por conveniência foi composta por 57 prontuários de casos de recém-nascidos microcefálicos. RESULTADOS: Em relação ao perfil dos recém-nascidos, 56,14% eram do sexo feminino, 85,96% tinham perímetro cefálico <32 cm, 82,45% Ápgar1` ? 7, 92,98% Ápgar 5 ?7 e 82,45% peso normal (2500-3999g). Quanto às características sociodemográficas das genitoras, 49,12% tinham entre 21 a 30 anos, 96,49% raça/cor parda, 26,3% ensino fundamental incompleto e 77,19% ocupação de doméstica. Durante o pré-natal, 8,77% realizaram exames de STORCH, 7,01% o exame de zika vírus, 8,77% exame para chikungunya e 3,50% sorologia para dengue. Em 2015, a microcefalia no estado foi considerada emergência de importância nacional. CONCLUSÃO: Houve predomínio de recém-nascido do sexo feminino e com perímetro cefálico <32. A maioria das genitoras eram adultas e com baixas condições socioeconômicas.
GASTRIC METASTASIS OF RENAL CELL CARCINOMA: A CASE REPORT
Authors: ERKILINÇ Gamze , BİRCAN Sema , BAŞPINAR Şirin , EVRİMLER Şehnaz , ŞENOL Altuğ , ERTUNÇ Onur , ÇETİN Bülent 
Published: April 2021

Primary gastric tumors are encountered more frequently
than metastatic tumors. The gastric metastasis of clear
cell renal cell carcinoma (CCRC) is very rare. We
herein report a case of gastric metastasis of CCRC.
A sixty-year-old man patient underwent a radical
nephrectomy and received adjuvant chemotherapy.
Pulmonary metastasis occurred at the second-year
follow-up, and interferon alpha-2a was used for
relapse. The Computed Tomography examination of
the patient presented with dyspepsia two years after
pulmonary metastases revealed 11 mm thickness in
the (along) gastric wall. Endoscopic examination was
suggestive of a neuroendocrine tumor.
Histopathologic evaluation of endoscopic biopsies
showed tumoral cell groups in a solid pattern composed
of clear, vacuolated cytoplasm. These tumor cells
were positive for RCC, PAX8 CD-10, Vimentin, and
immunohistochemistry findings were similar to the
initial tumor at diagnosis. Finally, the patient was
diagnosed with CCRC's gastric metastasis and treated
with a multi-targeted receptor tyrosine kinase inhibitor.
The Haidbach deposit in the Central Tauern Window, Eastern Alps, Austria: a metamorphosed orthomagmatic Ni-Cu-Co-PGE mineralization in the Polymetallic Ore District Venediger Nappe System – Hollersbach Complex
Authors: Melcher Frank , Schwabl Sonja , Onuk Peter , Meisel Thomas , Aiglsperger Thomas , Proenza Joaquín A. 
Published: April 2021

Abstract
Cu-Ni-Co-PGE mineralization occurs at Haidbachgraben in the Early Palaeozoic, Subpenninic Hollersbach Complex of the Central Tauern Window, Austria. Massive sulfide ore formed from sulfide melt segregated from silicate melt during intrusion of pyroxenite into magmatic rocks formed in an MORB-type environment. Relics of magmatic minerals include chromian spinel and polyphase sulfide droplets composed of pyrrhotite, chalcopyrite and pentlandite preserved in recrystallized pyrite. Both ore and host rocks were multiply deformed and metamorphosed, leading to hornblendite carrying the ore, enveloped by chlorite-epidote schist. Conditions of – likely Variscan – amphibolite facies metamorphism are documented by relict pargasitic cores in hornblende and actinolite-tremolite, and by ternary sulfarsenide compositions in the Co-Ni-Fe solid solution series that are the most common accessory minerals found in the sulfide ore. Pyrrhotite, pentlandite, chalcopyrite and pyrite are the major sulfide minerals. Chalcopyrite is Cd-rich and retains a high-temperature magmatic signature. High Co/Sb and moderate Se/As ratios in pyrite also point to a magmatic environment of mineralization. The accessory mineral assemblage of small grain size (mostly <10 µm) comprises native Au-Ag alloy and petzite as Au-Ag minerals, sperrylite, a variety of Pd tellurides and bismuthotellurides with elevated Sb, irarsite, and Re sulfides such as tarkianite and a Pb-Re sulfide. In addition, minor molybdenite, bournonite, scheelite and selenides have been identified. Two precious metal assemblages are present in individual samples: (1) hessite associated with Pd tellurides, often accompanied by sphalerite and chalcopyrite; (2) tarkianite forming euhedral inclusions in pyrite. Sperrylite and Au-Ag native alloys are present throughout and were also detected in silicate matrix. Most of the precious metal-bearing phases must have formed during recrystallization of base metal sulfides after the magmatic, and probably during later metamorphic events terminating in the Neoalpine Tauern crystallization.
RÉSIF-SI: A Distributed Information System for French Seismological Data
Authors: Péquegnat Catherine , Schaeffer Jonathan , Satriano Claudio , Pedersen Helle , Touvier Jérôme , Saurel Jean-Marie , Calvet Marie , Stehly Laurent , Arnoul Patrick , Bollard Philippe , Dewée Olivier , Engels Fabien , Grunberg Marc , Pardo Constanza , Wolyniec David , Arneodo Grégory , Bouazzouz Rima , Geber Olivier , Aubert Coralie , Langlais Mickaël , Roussel Sandrine , Brenguier Florent , Crawford Wayne C. , Lemarchand Arnaud , Maufroy Emeline , Olivier Serge , Rivet Diane , Vallée Martin , Vergne Jérôme , Chèze Jérôme , Debayle Éric , Delouis Bertrand , Guéguen Philippe , Lambotte Sophie , Mocquet Antoine , Paul Anne , Peix Fabrice , Schindelé François , Shapiro Nikolai , Stutzmann Éléonore , Volcke Pierre , Walpersdorf Andrea 
Published: April 2021

AbstractThe Résif project, which started in 2008, aims at gathering under a common research infrastructure the French seismological, Global Navigation Satellite Systems and gravimeter permanent networks, as well as the mobile instrument pools. A central part of Résif is its seismological information system, Système d'Information de Résif (Résif-SI) (started in 2012), which is in charge of collecting, validating, archiving, and distributing seismological data and metadata from seven national centers. Résif-SI follows a distributed architecture, in which the six data collection and validation centers (A-nodes) send validated data and metadata to a national data center (Résif Data Center [Résif-DC]), which is the central point for data archiving and distribution. Résif-SI is based on international standard formats and protocols, and is fully integrated into European and international data exchange systems (European Integrated Data Archive, European Plate Observing System [EPOS], Incorporated Research Institutions for Seismology, International Federation of Digital Seismograph Networks). In this article, we present the organization of Résif-SI, the technical details of its implementation, and the catalog of services provided to the end users. The article is aimed both at seismologists, who want to discover and use Résif data, and at data center operators, who might be interested in the technical choices made in the implementation of Résif-SI. We believe that Résif-SI can be a model for other countries facing the problem of integrating different organizations into a centralized seismological information system.
A comparative study of locking plate by minimally invasive percutaneous plate osteosynthesis versus closed interlocking intramedullary nail in extra-articular distal tibia fractures
Authors: Chitten Jojin Jose , Balasubramaniam R. 
Published: April 2021

<p><strong>Background</strong>: To compare functional outcome between minimally invasive percutaneous plate osteosynthesis (MIPO) and intramedullary interlocking nail (IMIL) in the distal one-third extra-articular tibia fracture.</p><p><strong>Methods</strong>: We retrospectively analysed 32 patients with closed distal tibia extra-articular fractures who underwent IMIL nail and locking plate MIPO technique in 16 patients each. All patients were followed for at least one year with assessment of clinico-radiological union and functional outcome scoring.</p><p><strong>Results</strong>: There was comparable functional outcomes, time to union and surgical time both in IMIL nail and MIPO fixation of closed distal extra-articular tibia fractures with similar complication rate. </p><p><strong>Conclusions</strong>: Our study suggests that both IMIL nail and MIPO fixation could be used for closed distal extra-articular tibia fractures as per surgeon’s preference. However, due to small sample size in our study, we cannot draw any definitive conclusions from our preliminary results but consider them as valuable basis for future studies.</p>
Reverse Sural Fascio-Cutaneous Flap for Management of Patients with Distal Third of Lower Limb Soft Tissue Defects Referring to the Emergency Department Following Traumatic Events; A Review of 13 Cases
Authors: Abdorrazzaghi Hosseinali , Hajibarati Babak , Mohammadi Fateme 
Published: April 2021

Introduction: Soft tissue defects over the distal leg and/or heel are probable injuries that need a flap. Various coverage techniques have been described in this regard. It seems that applying Reverse Sural Fascio-Cutaneous Flap (RSFCF) for reconstructing soft tissue defects of lower limbs has superiorities over other techniques. Objective: We intend to present a case series with soft tissue defect over the distal third of lower limb, covered using RSFCF technique.

Methods: This is a case series and longitudinal study in which patients with crush injuries who referred to the emergency department (Sina hospital, Tehran, Iran) from 2013 until 2020 and were treated with RSFCF technique were included. The data were collected using patients’ charts, by interviewing the patients, and from hospital records. The patients' wounds were prepared, examined, and the surgery was done. Tendon and bone defects were repaired, and wounds were closed using reverse sural Fascio-Cutaneous Flap.
Results: A total of 13 patients were eligible during the 6-year study period. Men were more commonly affected with no conclusive gender trend. The posterolateral part of the foot of the right leg was the most frequently injured part (53.8%). Only 1 patient had mentioned complications after surgery including mild congestion and abnormal sensory and motor examination. Patients were followed by the surgeons until 3 months after the operation and all of them had been able to resume their daily life activities by then.
Conclusion: According to our findings, almost all of the patients (except one) had received their flaps without any complications. All the patients had been able to resume their daily life activities three months after the surgery. This may show that RSFCF, which can be quickly performed and does not need microsurgical skills, could be a suitable option for the coverage of distal third of lower limb soft tissue defects caused mainly by trauma