bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualized Physical Activity Prescriptions for Children and Adolescents With Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Dong Yijie , Ban Yating , Zhong Ting , Guo Yijia , Tang Dongyan , Yu Runting , Liu Ke 
Published: December 2024

Background
For improved health outcomes, children and adolescents with cancer must maintain physical activity. Individualized physical activity prescription is an effective way to promote physical activity in this group.

Objective
We reviewed and meta-analyzed evidence on the effectiveness of individualized physical activity prescriptions for improving physical activity and other health outcomes among children and adolescents with cancer.

Methods
Seven databases were searched from inception up to January 2024 for randomized controlled trials. Two researchers independently extracted data and assessed the quality of studies using the Risk-of-Bias tool. Data were pooled into Review Manager 5.3 for data synthesis and subgroup analyses.

Results
Seventeen randomized controlled trials were included. The systematic review summarized the characteristics of recent interventions. Meta-analyses showed that although individualized physical activity prescriptions had no overall effect on physical activity (n = 8 studies), anthropometry and body composition (n = 5), functional capacity (n = 3), quality of life (n = 8), fatigue (n = 3), and self-efficacy (n = 5), they improved cardiovascular fitness (n = 8, P = .02) and muscle strength (n = 8, P = .04). Subgroup analyses showed that studies providing 6-month interventions (P = .003) or such interventions combined with motivational interviewing (P = .002) reported significantly increased physical activity in patients.

Conclusions
Individualized physical activity prescriptions appear to improve cardiovascular fitness and muscle strength in children and adolescents with cancer.

Implications for Practice
High-quality studies providing long-duration interventions and motivational interviewing are needed for optimal physical activity programs for children and adolescents with cancer. The application of electronic devices should increase the types of physical activities for this group to further improve health outcomes.
When It Really Counts
Authors: Anderson Ida , Grimley Karen , Miltner Rebecca 
Published: December 2024

OBJECTIVE
This program evaluation assessed the existing nursing workload acuity (NWA) tool embedded in the electronic health record at a large academic medical center in southern California.

METHODS
The NWA was evaluated using both quantitative and qualitative methods. The American Nurses Association's Principles for Nurse Staffing provided a conceptual framework with 5 core principles: healthcare consumer, interprofessional teams, workplace culture, practice environment, and evaluation.

RESULTS
Units met average staffing needs based on NWA 96% to 99% of the evaluation period. Statistical control charts revealed the shift-to-shift range of nurse staffing deficit to overage to be −2.0 to 2.2. Thematic analysis of charge nurse interviews revealed expertise in daily staffing decisions and knowledge deficits surrounding comprehensive nursing resource planning.

CONCLUSIONS
The tool provides valuable objective information that assists in both daily and annual nursing resource planning. A comprehensive evaluation of nursing resources should move beyond averages to include statistical control information to examine the nuances introduced by shift-to-shift staffing variances.
Atp6v0d2 deficiency partially restores defects in Mcoln1-deficient mouse corpus luteum
Authors: Li Yuehuan , El Zowalaty Ahmed E. , Hancock Jonathan Matthew , Wang Zidao , Martin Taylor Elijah , Zhan Tingjie , Wang Yingzheng , Andersen Christian Lee , Viswanathan Suvitha , Bromfield Jaymie , Atluri Venkata Abhigna , Kallish Karly Rae , Grismer Hope Nicole , Xiao Shuo , Ye Xiaoqin 
Published: December 2024

Objective:
ATP6V0d2 is a subunit of the vacuolar-type H+-ATPase (V-ATPase) that pumps H+ ions into lysosomes. TRPML1 (MCOLN1/Mcoln1) transports cations out of lysosomes. Mcoln1
−/− mice recapitulate the lysosomal storage disorder mucolipidosis type IV (MLIV) phenotype. We previously demonstrated that Mcoln1
−/− female mice quickly became infertile at 5 months old (5M) with degenerating corpora lutea (CL) and progesterone (P4) deficiency. We tested our hypothesis that Atp6v0d2 deficiency could partially compensate for Mcoln1 deficiency to restore CL functions in Atp6v0d2
−/−
Mcoln1
−/− mice.

Methods:
Control and Atp6v0d2
−/−
Mcoln1
−/− female mice underwent fertility test from 2M to 7M old. A subset of them was dissected at 5M on day 3.5 post-coitum (D3.5). The D3.5 ovaries from 5M old control, Mcoln1
−/−, and Atp6v0d2
−/−
Mcoln1
−/− mice were evaluated for CL morphology, lipid droplet staining, and markers of mitochondria and P4 steroidogenesis in the luteal cells.

Results:
The fertility test of Atp6v0d2
−/−
Mcoln1
−/− female mice (2M–7M) revealed normal mating activity but reduced fertility compared with the control; yet ~25% of them remained fertile at 5–7M but with dystocia. We analyzed a subset of 11 Atp6v0d2
−/−
Mcoln1
−/− mice (5M old) in the fertility test on D3.5: three (27.3%) had normal P4 levels and all examined CL parameters, indicating fully restoration of CL function compare with Mcoln1
−/−; whereas eight had P4 deficiency, with two (18.2%) infertile and six (54.5%) once fertile. In contrast to Mcoln1
−/− CLs, which had extensive amorphous cellular debris, indicating cell degeneration, Atp6v0d2
−/−
Mcoln1
−/− CLs had reduced amorphous cellular debris regardless of P4 levels. However, similar to Mcoln1
−/− CLs, P4-deficient Atp6v0d2
−/−
Mcoln1
−/− CLs showed impaired differentiation, enlarged lipid droplets, disorganized expression of endothelial basal lamina marker collagen IV, and reduced expression of mitochondrial marker HSP60 and steroidogenesis rate-limiting protein StAR, indicating that additional Atp6v0d2 deficiency compensates for Mcoln1 deficiency-induced cell degeneration, but is insufficient to restore luteal cell differentiation and P4 steroidogenesis in P4-deficient Atp6v0d2
−/−
Mcoln1
−/− CLs.

Conclusion:
This study shows that Atp6v0d2
−/−
Mcoln1
−/− CLs had varied improvements compared with Mcoln1
−/− CLs, and it provides in vivo genetic evidence of the coordination between different lysosomal channels in CL function.
C5aR1+ Macrophages are Involved in the Progression of Endometriosis
Authors: Chen Xi , Zuo Wei-Wen , Zhang Guo-Dong , Xu Cong-Jian 
Published: December 2024

Objective:
Immune dysfunction plays an important role in the pathogenesis of endometriosis. C5a, a by-product of complement activation, binds to its receptor (C5a receptor 1, C5aR1) in various cells, including macrophages. The combination of C5a and C5aR1 in macrophages induces M2 polarization. There is no consistent conclusion regarding macrophage polarization status and its participation in the pathogenesis of endometriosis.

Methods:
We analyzed the expression of C5aR1 and the immunophenotype of macrophages in samples from patients with endometriosis using immunohistochemistry and flow cytometry. We tested the equivalent item in a mouse model and the THP-1 cell line in vivo and in vitro. Single-cell RNA sequencing (scRNA-seq) from the Gene Expression Omnibus (GEO, GSE213216) was used to investigate the phenotype and function of C5aR1+ macrophages.

Results:
The infiltration of C5aR1+ macrophages were associated with the severity of endometriosis. C5aR1+ macrophages polarized more toward the M2 phenotype and transformed into an immunosuppressive state. Inhibiting C5aR1 using PMX-53 decreased the expression of C5aR1+ macrophages and reduced their polarization to the M2 phenotype, consequently shrinking lesion size in a mouse model.

Conclusion:
Our study emphasizes the importance of C5aR1 and the macrophage phenotype in the pathogenesis of endometriosis. We propose PMX-53 as a potential therapeutic agent for endometriosis.
Retrobulbar Hematoma: Presentation, Management, and Visual Outcomes
Authors: Elghannam Magdi , Hassan Bashar A.﻿ , Shams Nawal , Merbs Shannath L. , Manson Paul N. , Grant Michael P. 
Published: December 2024

Retrobulbar hematoma (RH) is a diagnostic and therapeutic emergency that may cause permanent vision loss. Lateral canthotomy and cantholysis (LCC) is typically performed when IOP is elevated or vision is compromised. The authors describe the outcomes of the largest cohort of patients with RH to date. Patients who presented with acute facial trauma and RH to the R. Adams Cowley Shock Trauma Center (2014–2022) were analyzed to describe their presentation, management, and visual outcomes. In 41 eyes (39 patients) with RH, the most common presenting ocular symptoms and signs were orbital pain [19 (46%)] and subconjunctival hemorrhage [33 (81%)], respectively. LCC was performed in half the cases (n=20). The median (IQR) intraocular pressure (IOP) was significantly higher in the LCC group versus observation: 33 mm Hg (26–44) versus 18 mm Hg (15–21) (P=0.001). Compared with the observation group, patients treated by LCC were significantly more likely to have no light perception (NLP) vision [0 (0%) versus 6 (50%), P=0.004] and higher IOP [median [IQR] 16 mm Hg (15–21) versus 33 mm Hg (23–44), P=0.001] at presentation. Although 1 of the 6 NLP patients managed by LCC regained some vision, LCC was not associated with significantly different odds of restoration of normal vision [aOR (95% CI) 0.32 (0.04–2.98)]. Visual acuity (VA) at presentation was the only significant predictor of visual acuity after follow-up (B=0.64, P=0.016). LCC is indicated for elevated IOP, as it effectively reduces IOP and improves intraocular perfusion. VA at presentation is the most reliable predictor of VA on follow-up.
Technology-assisted Pain Management in Pediatric and Adolescent Burn Care: A Systematic Review and Meta-analysis
Authors: Larasati Anjani , Widyani Ni Made Sarastri , Tania Felicitas 
Published: December 2024

Objective:
Burn injuries are one of the leading causes of disability in the pediatric and adolescent population globally. Current practice in pediatric burn management uses opioid analgesics as acute pain management. Technology-assisted pain management, including the application of video games and virtual reality (VR), offers an attractive alternative that can be used to help alleviate pain and anxiety in pediatric and adolescent patients with burns. This systematic review and meta-analysis aim to update and collate the most recent evidence on the effectiveness of said technologies in reducing pain and anxiety in pediatric and adolescent burn patients.

Methods:
The authors conducted a systematic search in the following databases: PubMed, Cochrane, Scopus, and ProQuest. Studies that applied any form of technology assistance and VR with participants 18 years or younger of age were included. Ten randomized controlled trials were included in the final analysis and were assessed with the primary outcome being the objective assessment of pain experienced by patients in said studies.

Results:
From the literature search conducted, 1224 articles were identified. Three reviewers independently screened titles and abstracts. Out of 1224 articles, 42 were included for full-text screen and review, and 32 were then excluded because they did not satisfy the inclusion and exclusion criteria. Nine randomized controlled trials and one quasi-experimental pilot study were included in the final systematic review and meta-analysis.

Conclusion:
Findings from this study demonstrate that VR and other forms of technological assistance are promising and effective in reducing pain in pediatric and adolescent patients with burns.
DKC1-mediated pseudouridylation of rRNA targets hnRNP A1 to sustain IRES-dependent translation and ATF4-driven metabolic adaptation
Authors: Gupta Anamika , Bansal Mohit , Ding Jane , Pandit Madhuparna , Sudarshan Sunil , Ding Han-Fei 
Published: December 2024

AbstractThe pseudouridine synthase DKC1 regulates internal ribosome entry site (IRES)-dependent translation and is upregulated in cancers by the MYC family of oncogenic transcription factors. We investigated the functional significance of DKC1 in MYCN-amplified neuroblastoma and its underlying mechanisms. A key function of DKC1 is to promote an ATF4-mediated gene expression program for amino acid metabolism and stress adaptation. We identified hnRNP A1, an IRES trans-acting factor, as a critical downstream mediator of DKC1 in sustaining ATF4 expression and IRES-dependent translation. We found that DKC1-mediated pseudouridylation at two specific 28S rRNA sites is essential for maintaining hnRNP A1 protein expression. Moreover, hnRNP A1 interacts with and stabilizes ATF4 mRNA, significantly increasing the protein expression of the ATF4 V1 variant, which contains an IRES element in its mRNA. Additionally, we found that cellular stress induces hnRNP A1, which is required for ATF4 induction under such conditions. Collectively, our study reveals a MYC-activated DKC1-hnRNP A1 axis that drives ATF4-mediated metabolic adaptation, supporting cancer cell survival under metabolic stress during cancer development.
Quantifying the ∼75-95% of Peptides in DIA-MS Datasets that were not Previously Quantified
Authors: Saxena Gautam , Fu Qin , Binek Aleksandra , Van Eyk Jennifer E 
Published: December 2024

AbstractWe demonstrate an algorithm termed GoldenHaystack (GH) that, compared to the leading DIA-MS algorithm, (a) quantifies and identifies with better FDR accuracy the peptides found in FASTA search spaces (∼5-25% of analytes in DIA-MS datasets), (b) quantifies the remaining ∼75-95% of analytes that were previously unquantified, and (c) runs ∼40-200x faster (or ∼1-10x faster than the LC-MS). Specifically, without a FASTA or spectral library, GH can deconvolute and accurately quantify chimeric LC-MS spectra. The central idea that enables this claim is: for sufficiently sized projects (e.g., ≥ ∼50 LC-MS files), pairs of peptides that co-elute in one subset of LC-MS files do not exactly co-elute in a different subset of files. GH thus analyzes a project holistically: it usesmulti-partite matching to match fragment ions across all samples, separates and regroups the fragment ions into unique analyte signatures, reduces stochastic noise, and then quantifies those unique analyte signatures.
Optimizing short food supply chains through understanding consumer preferences for organic foods via e-commerce platforms and last-mile logistics
Authors: Kumar Vikas , Sindhwani Rahul , Zhang Justin Zuopeng , Gaur Jighyasu 
Published: December 2024

PurposeThis paper investigates the impact of last-mile logistics on consumers’ intentions when purchasing organic foods through e-commerce. By addressing challenges such as trust, pricing and supply chain issues, the study aims to demonstrate how sustainable delivery options can improve consumer perceptions of the long-term viability of organic foods. It examines how e-commerce platforms can mitigate these challenges, drawing on the “Stimulus-Organism-Response” model and the “Theory of Planned Behavior” to explore the cognitive processes that shape consumer decisions in the context of organic food purchases. This research contributes to a deeper understanding of how last-mile logistics affect consumer behavior in online organic food shopping.Design/methodology/approachTo validate the proposed model, survey data were collected from 412 respondents across 19 Indian states through both online and offline channels. The data were analyzed using partial least squares structural equation modeling (PLS-SEM) with SmartPLS version 4. The study also examines the mediating role of perceived trust in influencing consumers’ willingness to pay for organic food adoption.FindingsThe study reveals that environmental concerns, last-mile logistics and website response time are key factors in determining consumers’ willingness to pay for organic foods. Furthermore, the findings indicate that price fairness and health consciousness significantly influence consumers’ behavioral intentions to purchase organic foods online.Social implicationsThe study emphasizes that consumer awareness campaigns are crucial for fostering green e-commerce adoption and achieving a sustainable future. It also underscores the potential of e-commerce platforms to address environmental and health concerns associated with organic food consumption.Originality/valueThis research highlights essential elements of organic food adoption that can increase consumer confidence, particularly through the role of last-mile logistics and e-commerce platforms. It underscores the importance of consumer awareness programs and education in promoting greener e-commerce practices, organic food adoption and a more sustainable future.
Is CSR a solution for crisis? Assessing the impact of three CSR dimensions on SME performance in the Nordic context
Authors: Kangas Emilia , Joensuu-Salo Sanna , Viljamaa Anmari 
Published: December 2024

PurposeThis study aims to investigate the relationship of corporate social responsibility (CSR) dimensions on the financial and nonfinancial performance of Finnish small and medium-sized enterprises (SMEs) amidst crises.Design/methodology/approachSurvey data was collected from 204 SME owner-managers in Finland during the COVID-19 pandemic using a purposive sampling technique, focusing on SMEs in South Ostrobothnia representing Finnish SMEs. The study tests the direct and indirect effects of CSR dimensions on both financial and nonfinancial performance during challenging times using linear regression analysis and path analysis with SEM.FindingsThe analysis reveals that CSR systems thinking competence positively affects financial performance but does not significantly impact nonfinancial performance. On the other hand, community social responsibility and socially responsible human resource management positively influence nonfinancial performance and have an indirect effect on financial performance.Originality/valueThis research underscores the beneficial performance outcomes of SME engagement in CSR during challenging times, emphasizing the enduring value of investing in employees. It highlights that despite industry performance affecting financial outcomes, CSR systems thinking competence contributes to financial performance and community social responsibility and socially responsible human resource management maintain a positive association with nonfinancial performance. Furthermore, this study enriches the existing literature on the CSR-SME performance relationship by exploring its effects within the unique context of a Nordic welfare society facing a crisis.
The development and validation of the Individual Knowledge Worker Proactivity Scale – an example from the Business Services Sector
Authors: Rogozińska-Pawełczyk Anna , Wiktorowicz Justyna 
Published: December 2024

PurposeProactivity is a multidimensional construct, influenced by many variables. The purpose of this paper is to develop a standardised, psychometrically robust tool for the emerging construct of knowledge worker proactivity.Design/methodology/approachUsing a systematic framework to design a survey questionnaire as a reference point (i.e. creating items, item reduction and scale evaluation), this article discusses the development and validation of an instrument that can be used to measure individual knowledge worker proactivity. Analysis was based on data from the random (calibration) sample of 500 non-managers and 500 managers employed in the Business Services Sector (BSS) (piloting sample: 256 employees, validating sample: 155 employees and managers). Statistical analysis was conducted using especially confirmatory and exploratory analysis, reliability and validity measures, structural modelling.FindingsThe analysis confirms that the three-dimensional proactivity model can be successfully applied to BSS. All important fit indices of the confirmatory factor analysis model showed a good fit, and the model proposed for knowledge worker proactivity has appropriate validity.Research limitations/implicationsThe results suggest that the proposed Individual Knowledge Worker Proactivity (IKWP) Scale is internally reliable and valid in the sense that it is conceptually and empirically correlated with proactive work behaviours, proactive strategic behaviours and proactive person–environment fit behaviour constructs.Originality/valueA comprehensive and BSS-specific scale has been created to assess the proactive behaviour of knowledge workers and their managers. This opens the way for the instrument to be used in practice, e.g. by talent or employee teams to work more effectively on new innovative solutions or by top management as a support for key decisions within the organisation.
Optimizing supplier selection for prefabricated components: a comprehensive evaluation
Authors: Lin Chengxin , Chen Jieyi , Feng Chao , Li Xiaojuan 
Published: December 2024

PurposePrefabricated building has emerged as a hallmark of modern construction industrialization and a pivotal driver of industrial upgrading. In this new building type, the supply of high-quality prefabricated components plays a crucial role in ensuring project quality, cost-effectiveness and on-time completion. Consequently, selecting the optimum suppliers for these components is vital. This study provides valuable insights for construction enterprises, guiding them in the optimal selection of prefabricated component suppliers and thereby contributing to the sustainable development of the construction industry.Design/methodology/approachThe entropy weight method is used to integrate and rank 19 commonly used evaluation indices, forming a supplier evaluation system from the enterprises perspective. Subsequently, the VIKOR multi-attribute decision model, combined with a comprehensive evaluation method based on cloud modeling, is applied to identify the most suitable suppliers through case study.FindingsThe findings emphasized that product quality, particularly the component compliance rate, is paramount in supplier selection. Additionally, companies should prioritize cost management and fundamental supplier capabilities, such as transportation efficiency and operational flexibility, while fostering strong partnerships with high-quality suppliers. Furthermore, all stakeholders need to enhance the supply chain’s responsiveness and adaptability, ensuring these improvements are achieved without strict cost controls.Originality/valueThis study minimizes the influence of subjective biases from decision-makers’ by integrating quantitative and qualitative analysis methods, thereby enhancing the comprehensiveness and accuracy of evaluations. By effectively addressing the fuzziness and uncertainty inherent in evaluation data, it establishes a robust system for selecting prefabricated building suppliers. This approach offers reliable and practical decision support, providing theoretical backing for enterprises in choosing prefabricated component suppliers and promoting the sustainable development of the prefabricated construction industry.