bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insular epilepsy surgery: lessons learned from institutional review and patient-level meta-analysis
Authors: Kerezoudis Panagiotis , Singh Rohin , Goyal Anshit , Worrell Gregory A. , Marsh W. Richard , Van Gompel Jamie J. , Miller Kai J. 
Published: October 2021

OBJECTIVE
Insular lobe epilepsy is a challenging condition to diagnose and treat. Due to anatomical intricacy and proximity to eloquent brain regions, resection of epileptic foci in that region can be associated with significant postoperative morbidity. The aim of this study was to review available evidence on postoperative outcomes following insular epilepsy surgery.

METHODS
A comprehensive literature search (PubMed/MEDLINE, Scopus, Cochrane) was conducted for studies investigating the postoperative outcomes for seizures originating in the insula. Seizure freedom at last follow-up (at least 12 months) comprised the primary endpoint. The authors also present their institutional experience with 8 patients (4 pediatric, 4 adult).

RESULTS
A total of 19 studies with 204 cases (90 pediatric, 114 adult) were identified. The median age at surgery was 23 years, and 48% were males. The median epilepsy duration was 8 years, and 17% of patients had undergone prior epilepsy surgery. Epilepsy was lesional in 67%. The most common approach was transsylvian (60%). The most commonly resected area was the anterior insular region (n = 42, 21%), whereas radical insulectomy was performed in 13% of cases (n = 27). The most common pathology was cortical dysplasia (n = 68, 51%), followed by low-grade neoplasm (n = 16, 12%). In the literature, seizure freedom was noted in 60% of pediatric and 69% of adult patients at a median follow-up of 29 months (75% and 50%, respectively, in the current series). A neurological deficit occurred in 43% of cases (10% permanent), with extremity paresis comprising the most common deficit (n = 35, 21%), followed by facial paresis (n = 32, 19%). Language deficits were more common in left-sided approaches (24% vs 2%, p < 0.001). Univariate analysis for seizure freedom revealed a significantly higher proportion of patients with lesional epilepsy among those with at least 12 months of follow-up (77% vs 59%, p = 0.032).

CONCLUSIONS
These findings may serve as a benchmark when tailoring decision-making for insular epilepsy, and may assist surgeons in their preoperative discussions with patients. Although seizure freedom rates are quite high with insular epilepsy treatment, the associated morbidity needs to be weighed against the potential for seizure freedom.
Potensi dan Masalah Kawasan Pesisir Desa Sigarpenjalin Sebagai Kawasan Strategis Kabupaten Lombok Utara
Authors: Yuniarman Ardi , Kurniawan Agus , Sutikno Dodik , Insyan Osy 
Published: October 2021

Sektor pariwisata pada era otonomi daerah sekarang ini hanya semata-mata untuk meningkatkan Pendapatan Asli Daerah. Fenomena ini sering terjadi di dalam pengembangan dan perencanaan kawasan terutama kawasan yang berada di wilayah pesisir, sehingga perlunya penelitian ini untuk mengkaji lebih dalam terhadap potensi dan masalah yang ada di Desa Singar Penjalin, sehingga pentingnya penelitian ini untuk melihat potensi dan masalah pada kondisi fisik kawasan baik secara fisik dasar maupun fisik binaan. Metodologi penelitiaan ini menggunakan pendekatan deskriptif kwalitatif. Dari hasil yang ditemukan bahwa Kawasan Desa Singgar Penjalin merupakan kawasan pintu masuk kawasan Administrasi Perkotaan Tanjung yang melintang dari luar menuju kawasan pusat pemerintahan dengan beberapa kegiatan pariwisata dan fasilitas penunjang seperti hotel, kafe dan lapangan Golf, sudah memiliki arah pengembangan sebagai kawasan pariwisata dalam peraturan daerahnya, topografi yang variatif berpotensi memberikan atraktif sebagai kawasan wisata serta jenis tanah yang cocok sebagai fungsi pertanian. Ketidak jelasan pola pengembangan kawasan terlihat banyaknya alis fungsi lahan yang besar, susahnya mengidentifikasi kawasan akibat dari kurang kuatnya penanda kawasan dan citra sebagai ciri khas kawasan, pemanfaatan dan pembangunan fisik di area sempadan pantai yang merupakan kawasan lindung, serta akses yang masih kurang baik menuju kawasan wisata sepanjang pantai di Desa Sigar Penjalin.Abstract: The tourism sector in the current era of regional autonomy is only to increase Regional Original Income. This phenomenon often occurs in regional development and planning, especially areas located in coastal areas, so the need for this research is to examine more deeply the potential and problems that exist in Singar Penjalin Village, so the importance of this research is to see the potential and problems in the physical condition of the area. both basic physical and built physical. This research methodology uses a qualitative descriptive approach. From the results, it was found that the Singgar Penjalin Village Area is the entrance area of the Tanjung Urban Administration area that crosses from the outside to the central government area with several tourism activities and supporting facilities such as hotels, cafes and golf courses, already has a development direction asa tourism area in its regional regulations. , the varied topography has the potential to provide attractiveness as a tourist area as well as suitable soil types as agricultural functions. The unclear pattern of regional development can be seen from the large number of eyebrows of land functions, the difficulty of identifying areas as a result of the lack of strong regional markers and images as regional characteristics, physical use and development in the coastal border area which is a protected area, and poor access to the area. along the coast in Sigar Penjalin Village.
Peran Kepuasan Pelanggan Pada Hubungan Kausalitas Antara Kualitas Layanan Terhadap Niat Beralih
Authors: Rusdiana Alan , LM L Suparto 
Published: October 2021

This type of research is associative research. This research takes the title: “This type of research is associative research. This research takes the title: "The Role of Customer Satisfaction on the Causality Relationship Between Service Quality and Switch Intention (Study on Fitra Majalengka hotel visitors)”.
The purpose of this study was to determine the partial effect of core service quality and encounter on switching intentions with the mediating factor of customer satisfaction.
The population in this study were all visitors to the Fitra Majalengka hotel. The sampling technique used is purposive sampling. The number of respondents in this study was 120. The data were analyzed using structural equation modeling (SEM) with AMOS 21 software.
The results of this study indicate that 1) core service quality has no effect on switching intentions, 2) encounter service quality has no effect on switching intentions, 3) core service quality has a positive effect on customer satisfaction, 4) encounter service quality has a positive effect on customer satisfaction, 5 ) customer satisfaction has a negative effect on switching intentions, 6) customer satisfaction mediates the negative effect of core service quality on switching intentions, 7) customer satisfaction mediates the negative effect of encounter service quality on switching intentions. An important finding from this study is that it can confirm the concept of EDT in which customer satisfaction becomes a mediating variable between the relationship between core service quality and encounter with switching intentions.
Pengaruh Keadilan Prosedural Partisipatif Dan Pengembangan Karir Terhadap Kinerja Karyawan Pada PT. Pancaragam Toyindo Majalengka
Authors: Qustolani Asep , Rusyanti  
Published: October 2021

Performance is the work achieved by a person in carrying out his duties or work both in quantity and quality, namely in accordance with responsibilities and is the result of work that has been achieved by someone with predetermined standards. This research was conducted at PT. Pancaragam Toyindo Majalengka, as for the purpose of this study is to determine the effect of participatory procedural justice variables and career development on employee performance.
The research method used in this research is a survey method with a descriptive verification approach. The data obtained are primary data, namely data from respondents' responses which are distributed to respondents. Population of all employees as many as 200 people and a sample taken is 100 people. The analytical tools used in this research are validity test, reliability test, classical assumption test, multiple linear regression, coefficient determination and hypothesis testing, for partial test using t test and model feasibility test.
Based on the results of hypothesis testing, participatory procedural justice has a positive and significant effect on employee performance. Career development has a positive and significant effect on employee performance at
HUBUNGAN FREKUENSI LAMA MENJALANKAN HD DENGAN KADAR TROMBOSIT PADA PASIEN CKD DI RSPBA BANDAR LAMPUNG
Authors: Jannah Nurul , Rusmini Hetti , Purwaningrum Ratna , Kriswiastiny Rina 
Published: October 2021

Chronic Kidney Disease (CKD) merupakan masalah yang sangat serius, dimana terjadi kerusakan ginjal yang terjadi selama lebih dari 3 bulan, terapi yang biasa dilakukan untuk pasien ckd adalah dengan melakukan hemodialisa dimana digunakan untuk mengambil zat – zat nitrogen yang bersifat toksik dari dalam darah, tindakan tersebut mempunyai efek samping pada kondisi fisik serta psikologis penderita CKD. Trombosit memiliki peran penting yaitu melindungi integritas endotel pembuluh darah dalam proses hemostasis apabila terjadi kerusakan pada dinding pembuluh darah. Hasil pemeriksaan hitung trombosit dipengaruhi oleh suhu dan waktu sejak pengumpulan spesimen. Hasil pemeriksaan hitung trombosit dipengaruhi oleh suhu dan waktu sejak pengumpulan spesimen. Pada pemeriksaan laboratorium bisa terjadi kelainan pada trombosit yaitu trombositopenia dan trombositosis. Penelitian ini bersifat analitik retrospektif dengan desain cross sectional. Teknik pengambilan sampel secara total sampling, dengan sampel yang dipakai sebanyak 76. Berdasarkan lama menjalankan perawatan HD terhadap kadar trombosit diperoleh (p-value = 0,294), sedangkan lama waktu pelaksanaan HD terhadap kadar trombosit (p-value 0,014). Tidak terdapat hubungan yang signifikan lama menjalankan perawatan HD dengan kadar trombosit pada pasien CKD, dan terdapat hubungan yang signifikan lama proses HD dengan kadar trombosit pada pasien CKD di RSPBA Bandar Lampung Tahun 2019 – 2020.
Acidente Vascular Encefálico: uma revisão de escopo
Authors: Darwiche Mustafa , Fronza Dilson 
Published: October 2021

O AVE é uma doença com alta carga de morbimortalidade a nível nacional e global. Nos Estados Unidos é a quinta principal causa de morte, com prevalência geral de 2,6% no período entre 2009 e 2012. No Brasil, estima-se que há 2.231.000 pessoas com AVC e 568.000 com incapacidade grave. Este artigo busca descrever características deste agravo agudo para auxiliar os profissionais de saúde no encontro de informações importantes relacionadas a esta patologia. Fatores de risco como hipertensão arterial sistêmica (HAS), diabetes, dislipidemia, fibrilação atrial e estenose de carótidas foram associadas a maior risco de desenvolvimento de AVE, sendo a HAS a mais importante. Embora sinais e sintomas clínicos sejam importantes, a neuroimagem é fundamental para diferenciação dos quadros de AVE isquêmico do hemorrágico para guiar o tratamento mais adequado. Alguns dos diagnósticos diferenciais do AVE são acidente isquêmico transitório (AIT), convulsões, cefaleia, hipoglicemia, tumores, vertigem e alteração do estado mental. Algumas complicações médicas após AVEs são disfagia, incontinência urinária, embolia pulmonar, trombose venosa profunda (TVP), pneumonia, depressão e úlceras de pressão. É de extrema importância o diagnóstico correto e precoce do Acidente Vascular Encefálico (AVE) para evitar as sequelas deste evento agudo e o tratamento adequado da HAS, diabetes mellitus e dislipidemia são de grande importância para redução da elevada prevalência de AVE.
Relationship between obesity and musculoskeletal disorders: systematic review and meta-analysis
Authors: Fortunato Lucas Marques , Kruk Tatielly , Lima Júnior Emilton 
Published: October 2021

Introduction: Obesity is considered a public health problem and it is associated with various musculoskeletal disorders, that haven´t been reviewed systematically. Therefore, the objective of this study was to describe the relationship between these changes in individuals with obesity. Methods: Lilacs, PubMed, Scielo, Scopus and Web of Science electronic databases were systematically reviewed until July 2018, conducted according to Cochrane guidelines for the development of meta-analysis. Eligibility criteria: inclusion (studies with humans; with a BMI greater than 30 Kg/m² or above the 85th and 95th percentile for children and adolescents; articles published in Portuguese, English, and Spanish; articles with validated evaluation methods); exclusion (duplicate, non-indexed articles; special populations; meeting summaries, editorials, letters to the editor and reviews). Results: Based on moderate evidence, knee postural changes in patients with obesity were found in two studies (n=158) (OR 14,26, IC 95% 4,98-40,80), I2 = 0% (p = 0,000), foot postural changes were found in 3 studies (n =338) (OR 3,20, IC 95% 2,08-4,94), I2=0% (p=0,000). Two studies were identified for arthritis (n=1331) (OR 3,38, IC 95% 0,72-1582), I2=38,95% (p=0,122). Pain was reported in the lower limb and the spine. Four studies were found for the former (n=1560) (OR 5,51 IC 95% 2,07-14,61), I2=81,02% (p=0,001), and three for the latter (n=499) (OR 9,78 IC 95% 2,59-36,93), I2=86,58% (p=0,000). Conclusion: Results show that obesity has a negative impact on musculoskeletal health, with results statistically significant for knee and foot postural changes, arthritis, and pain in the spine and lower limbs.
Immunological evaluation of the crevicular fluid in patients with gingivitis, periodontitis, and peri-implantitis: a 1-year cross-sectional study
Authors: Faria Juliana Barbosa de , Furtado Taíssa Cássia de Souza , Assunção Thaís Soares Farnesi de , Abdalla Douglas Reis , Andrade Fabiane Minin , Bertoldo Bárbara Bellocchio , Amaral Eleonora de Paula , Rodrigues Denise Bertulucci Rocha , Rodrigues Júnior Virmondes , Pereira Sanivia Aparecida de Lima 
Published: October 2021

Objective: To assess the levels of IL-12, IL-15, IL-18, and IL-32 in the gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) in patients with gingivitis, periodontitis, and peri-implantitis before and one year after implant installation. Material and Methods: Forty-nine samples of GCF and PICF were collected from March 2018 to March 2019. The patients were classified: patients with gingivitis (n=7), patients with periodontitis (n=14), patients with peri-implantitis (n=4) and healthy patients (n=24). The crevicular fluid from the 49 patients was collected before implant installation (n=8) and one year after implant placement (n=8). The Enzyme-Linked Immunosorbent Assay (ELISA) was used to evaluate the levels of cytokines in crevicular fluid. Results: Patients with gingivitis, periodontitis, and peri-implantitis showed higher concentrations of IL-12, IL-15, IL-18, and IL-32 when compared with control group. In general, the levels of IL-12 and IL-15 increased when compared to the moments before and after implant installation. There was also an increase in the concentration of IL-18 in the control group volunteers after implant installation. Conclusion: The results and methodology of this study showed that there was no difference in the synthesis of IL-12, IL-15, IL-18, and IL-32 in healthy individuals or in those with periodontal injuries. However, there was an increase in the cytokines IL-12, IL-15, and IL-18 one year after implant installation, which would be increasing the inflammatory activity in peri-implantitis.
Estudo morfoanatômico, análise química e biológica do extrato metanólico das folhas de Mabea angustifolia Spruce ex Benth. (Euphorbiaceae)
Authors: Trindade Ívina Thayna Miranda , Silva Rafaela Rolim da , Guesdon Isabel Reis , Abegg Maxwell Adriano , Corrêa Geone Maia , Carmo Dominique Fernandes de Moura do 
Published: October 2021

Este estudo teve como objetivo avaliar o perfil químico do extrato metanólico (EMA-Met) das folhas de Mabea angustifolia Spruce ex Benth., sua ação biológica e descrever sua morfoanatomia. As folhas de M. angustifolia foram coletadas no município de Itacoatiara, Amazonas, Brasil. Em seguida, foram secas, trituradas e submetidas à extração com solventes em ordem crescente de polaridade. O extrato EMA-Met foi submetido às análises por espectrometria de massas (APCI-MS) e avaliado por triagem fitoquímica. A ação biológica dos extratos foi testada nas leveduras Candida albicans (C.P. Robin) Berkhout 1923, Candida parapsilosis (Ashford) Langeron & Talice 1932 e nas bactérias Salmonella Lignieres 1900 spp., Escherichia coli (Migula 1895) e Staphylococcus aureus Rosenbach 1884. A análise morfoanatômica das folhas identificou características valiosas para a identificação da espécie, como a forma e margem foliar, número e posição de nectários e coléteres, tricomas tectores ramificados e células papilosas na face abaxial da epiderme. A análise fitoquímica revelou a presença de saponinas, taninos condensados, fenóis e flavonoides. A análise por APCI– MS permitiu identificar flavonoides de reconhecida atividade biológica na literatura, sendo dois O- glicosídeos da quercetina, o 3-O-α-L-arabinopirasil quercetina e a quercetina-3-O-glucuronídeo, além da quercetina e a miricetina-3-O-ramanosídeo. A solução do extrato na concentração de 10 mg/mL inibiu a E. coli, com diâmetro médio do halo de 5 mm, o halo de inibição para C. albicans apresentou diâmetro médio de 15 mm e para C. parapsilosis foi de 16 mm. Os resultados são promissores, evidenciando o potencial antimicrobiano de M. angustifolia.
Formação docente: o contexto de pandemia COVID-19 e a atuação docente universitária no Brasil
Authors: Pereira Higinalice da Silva , Araújo Dakson Douglas , Xavier Filho José Ricardo Teixeira , Lima Neto Francisco Edmar Moreira de , Brito Manoel da Paixão , Silva Júnior Emanuel Carvalho , Veras Raiane Assunção , Silva Francisca Maria Leite , Costa João Marcos Antônio Rodrigues da 
Published: October 2021

A pandemia causada pelo novo coronavírus afetou a sociedade em diversos aspectos. No que diz respeito ao ensino e a necessidade de adequação às recomendações das organizações de saúde, as instituições buscaram nas estratégias de atividades educacionais remotas, uma alternativa para manter seus alunos em atividades acadêmicas. Objetivou-se com a revisão integrativa descrever os desafios e as possibilidades encontrados pelos educadores no processo ensino aprendizagem e a didática no espaço virtual nessa mudança emergencial. A pesquisa foi realizada nas bases de dados eletrônicas Scielo, Periódicos Capes e Biblioteca Virtual em Saúde (BVS) na busca por publicações em formato de artigos, compreendendo o período de 2020 a 2021, considerando os seguintes descritores: “ensino superior” “COVID-19” “ensino online” ”docente” e aplicando critérios de inclusão e exclusão.Foram encontrados 56 artigos (n=56), que foram reduzidos para (n=13) após análise. Os dados demonstram que a corrida para garantir a continuidade do ensino e a ausência de capacitação e formação continuada para manejo das tecnologias digitais resultaram na promoção de aulas remotas nos mais variados níveis e apesar dos esforços, o ensino remoto emergencial trouxe implicações negativas no processo de ensino-aprendizagem. No entanto, alguns trabalhos demonstram que quando se tem o conhecimento sobre a ferramenta é possível aumentar o engajamento dos alunos nas aulas.Esperamos contribuir tanto na reflexão crítica acerca da formação continuada de professores do ensino superior como fomentar as discussões da integração das TDIC aos currículos do Ensino Superior presencial.
Fratura Le Fort I em paciente vítima de acidente motociclístico: relato de caso
Authors: Cavalcante Vinícius Fernandes , Lima Diego Learth , Oliveira Neto Jair Queiroz de , Carneiro Junior Helder Cavalcante , Pinho Filho João Eudes Teixeira , Teixeira Neto Murilo Alves 
Published: October 2021

Relato de caso: Paciente F.J.L., gênero masculino, 51 anos de idade, normossistêmico, compareceu ao serviço de Cirurgia e Traumatologia Buco-Maxilo-Facial do Hospital Batista Memorial, Fortaleza / CE. Durante a avaliação clínica verificou-se mobilidade de maxila, presença de degrau em pilar zigomático bilateralmente, degrau em margem infra-orbitária e diplopia monocular em olho esquerdo. Após a análise do exame imaginológico foi constatado fratura do tipo Le Fort I e do complexo zigomático e em seguida o paciente foi submetido a cirurgia sob efeito de anestesia geral para realização de osteossíntese das fraturas faciais, utilizando placas e parafusos do sistema 2.0mm e 1.5mm. Atualmente, o paciente se encontra em acompanhamento pós-operatório de 6 meses sem queixas estéticos funcionais. Conclusão: A realização do tratamento realizado precocemente aliado ao correto planejamento das fraturas maxilofaciais minimizam significativamente os riscos de comprometimento estético-funcional, assim favorecendo o retorno precoce dos pacientes ao convívio social e minimizando os riscos de complicações pós-operatórias.
Determinação dos limiares auditivos de forma objetiva e automática em adultos normo-ouvintes
Authors: Potgurski Dayane Stephanie , Ribeiro GeorgeaEspindola , Silva Daniela Polo Camargo da 
Published: October 2021

Objetivo: verificar a aplicabilidade do exame de resposta auditiva de estado estável (RAEE), correlacionando os limiares auditivos obtidos neste exame com os limiares auditivos obtidos na audiometria tonal liminar (ATL) em indivíduos sem queixas auditivas. Metodologia: Foram avaliados 15 indivíduos adultos normo-ouvintes. A avaliação foi composta pela ATL e RAEE, ambas para verificação do grau da audição, sendo a primeira uma medida comportamental e a segunda, eletrofisiológica. Na ATL foram avaliadas a acuidade auditiva nas frequências de 250, 500, 1000, 2000, 3000, 4000, 6000 e 8000 Hz, de ambas as orelhas. A pesquisa da RAEE foi realizada em modo multifrequencial e dicótico, ou seja, foram pesquisas as frequência de 500, 1000, 2000 e 4000 Hz nas duas orelhas ao mesmo tempo, com o objetivo de avaliar o nível mínimo de resposta obtido de maneira automática. Resultados: Na ATL os limiares obtidos estiveram abaixo de 25 dBNA para todas as frequências avaliadas e a mediana dos valores encontrados foram menores do que os valores medianos encontrados na RAEE. No teste de correlação de Spearman, houve correlação significativa apenas na frequência de 500 Hz. Conclusão: Os limiares auditivos obtidos pela RAEE foram detectados em todos os participantes do estudo e os valores foram superiores aos encontrados na ATL, entretanto é comum os resultados eletrofisiológicos serem superiores aos observados em exames comportamentais. Não houve correlação entre os limiares obtidos entre as técnicas para a maioria das frequências avaliadas, em indivíduos adultos normo-ouvintes. Desta forma, sugere-se a realização de pesquisas futuras com um maior tamanho amostral, adotando-se a mesma metodologia aplicada nesse estudo.