bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining video telemetry and wearable MEG for naturalistic
imaging
Authors: O’Neill George C. , Seymour Robert A. , Mellor Stephanie , Alexander Nicholas A. , Tierney Tim M. , Bernachot Léa , Fahimi Hnazaee Mansoureh , Spedden Meaghan E. , Timms Ryan C. , Bush Daniel , Bestmann Sven , Brookes Matthew J. , Barnes Gareth R. 
Published: February 2025

Abstract
Neuroimaging studies have typically relied on rigorously controlled experimental paradigms to probe cognition, in which movement is restricted, primitive, an afterthought or merely used to indicate a subject’s choice. Whilst powerful, these paradigms do not often resemble how we behave in everyday life, so a new generation of ecologically valid experiments are being developed. Magnetoencephalography (MEG) measures neural activity by sensing extracranial magnetic fields. It has recently been transformed from a large, static imaging modality to a wearable method where participants can move freely. This makes wearable MEG systems a prime candidate for naturalistic experiments going forward. However, these experiments will also require novel methods to capture and integrate information about behaviour executed during neuroimaging, and it is not yet clear how this could be achieved.
Here we use video recordings of multi-limb dance moves, processed with open-source machine learning methods, to automatically identify time windows of interest in concurrent, wearable MEG data. In a first step, we compare a traditional, block-designed analysis of limb movements, where the times of interest are based on stimulus presentation, to an analysis pipeline based on hidden Markov model states derived from the video telemetry. Next, we show that it is possible to identify discrete modes of neuronal activity related to specific limbs and body posture by processing the participants’ choreographed movement in a dancing paradigm. This demonstrates the potential of combining video telemetry with mobile magnetoencephalography and other legacy imaging methods for future studies of complex and naturalistic behaviours.
Oscillatory signatures of monitoring and anticipatory strategies for
probabilistic vs deterministic cues
Authors: Tarasi Luca , Bertaccini Riccardo , Ippolito Giuseppe , Martelli Maria Eugenia , di Pellegrino Giuseppe , Romei Vincenzo 
Published: February 2025

Abstract
Perception is not exclusively determined by sensory input, being strongly shaped by expectations. Here, we manipulated target occurrence certainty - random (50%), probabilistic (63/75%), deterministic (100%) - to investigate how priors shape decision-making. Results revealed strong influence of expectations on decision-bias, with modulation increasing as priors attain predictive power. This influence was particularly evident in deterministic trials, where the prior’s absolute validity heightened performance. Notably, individuals exhibited wide variability in predictive strategies: some exhibited strong prior-driven choice (believers), while others relied more on sensory input (empiricists). Relative to empiricists, believers exhibited reduced midfrontal theta rhythm in probabilistic trials, indicating less monitoring for actual target occurrence, and higher motor beta desynchronization in deterministic trials, suggesting a shift toward motor strategy implementing prior-congruent action. Crucially, believers' prior-driven approach conferred an advantage in deterministic conditions. These findings highlight priors' impact on decision-making, emphasizing the interplay between monitoring and anticipatory mechanisms in leveraging expectations.
Implicit Neural Representation of Multi-shell Constrained Spherical
Deconvolution for Continuous Modeling of Diffusion MRI
Authors: Hendriks Tom , Vilanova Anna , Chamberland Maxime 
Published: February 2025

Abstract
Diffusion magnetic resonance imaging (dMRI) provides insight into the micro and macro-structure of the brain. Multi-shell multi-tissue constrained spherical deconvolution (MSMT-CSD) models the underlying local fiber orientation distributions (FODs) using the dMRI signal. While generally producing high-quality FODs, MSMT-CSD is a voxel-wise method that can be impacted by noise and produce erroneous FODs. Local models also do not use the spatial correlation between neighboring voxels to increase parameter estimating power. Additionally, voxel-wise methods require interpolation at arbitrary locations outside of voxel centers. These interpolations can be computationally costly or inaccurate, depending on the method of choice. Expanding upon previous work, we apply the implicit neural representation (INR) methodology to the MSMT-CSD model. This results in an unsupervised machine learning framework that generates a continuous representation of a given dMRI dataset. The input of the INR consists of coordinates in the volume, which produce the spherical harmonics coefficients parameterizing an FOD at any desired location. A key characteristic of our model is its ability to leverage spatial correlations in the volume, which acts as a form of regularization. We evaluate the output FODs quantitatively and qualitatively in synthetic and real dMRI datasets and compare them to existing methods.
Tramadol and mental health: A systematic review of case reports describing psychological side-effects
Authors: Gudla Sai Shashank , Bhumireddy Siva Krishna Adithya , Vadaga Anil Kumar 
Published: February 2025

Objective Tramadol is a synthetic opioid widely used in clinical practice to treat moderate to severe pain. While it is considered safer than traditional opioids, growing concerns have emerged regarding its adverse psychological effects. This systematic review examined tramadol-induced psychological side effects, identified risk factors, and evaluated possible underlying mechanisms that might help to guide safer clinical use. Methods A systematic search was conducted in PubMed, Scopus, Web of Science, and Google Scholar using the related keywords of tramadol and psychological effects. This review primarily focused on case reports, which were included if they provided detailed accounts of tramadol-induced mental health side-effects. Two independent reviewers screened the studies, and data was extracted on patient demographics, details of tramadol usage, psychological outcomes, and risk factors. The quality of the case reports was assessed using the Joanna Briggs Institute (JBI) scale. Results The review found that tramadol is associated with a range of psychological symptoms, including manic episodes, hypomania, serotonin syndrome, psychosis, and cognitive impairment. Risk factors included age, pre-existing psychiatric conditions, polydrug use, and prolonged tramadol use. Elderly individuals and those with psychiatric histories were particularly vulnerable. Conclusion Tramadol has the potential to cause serious psychological side effects, prompting cautious prescription, especially in vulnerable populations. Clinicians should closely monitor patients for these adverse effects, and further research is needed to understand the mechanisms involved and to reduce the psychological site-effects resulting from tramadol use.
Evaluation of the impact of extracorporeal membrane oxygenation (ECMO) oxygenator shunt flow on neonatal hemolysis: An in vitro study
Authors: Nemeh Christopher , Varner Caleb , Schmoke Nicholas , Trager Elon , Wu Yeu Sanz , Brewer Michael , Cain-Trivette Caitlin , Aw Nikki , Francis Richard O , Vargas Chaves Diana , Cheung Eva W , Middlesworth William 
Published: February 2025

Introduction Extracorporeal membrane oxygenation (ECMO) is utilized in critically ill neonates with severe cardiopulmonary failure. Hemolysis is a potential complication and is associated with significantly increased morbidity and mortality. The etiology of hemolysis in neonates is multifactorial, including shear forces generated by the ECMO pump, higher flow resistance from smaller tubing and smaller cannulas, the oxygenator, and other patient factors. Centrifugal pumps and oxygenators commonly have shunts with partially occluding clamps to regulate blood flow. We hypothesized that these clamps are significant contributors to hemolysis. Method An in vitro study was conducted with three identical ECMO circuits containing an integrated polymethylpentene (PMP) oxygenator and centrifugal pump (Cardiohelp HLS 5.0) and 1/4″ arteriovenous (AV) loop tubing. The circuits were primed with equal components, including expired ABO-compatible packed red blood cells (pRBCs), 25% albumin, 5% albumin, sodium bicarbonate, heparin, and calcium chloride. Circuit A had a completely occluded shunt. Circuit B had a partially occluded shunt, allowing 500 mL/min of shunt flow back to the oxygenator. Circuit C had a fully open shunt, generating 1000 mL/min of shunt flow back to the oxygenator. Plasma-free hemoglobin values were measured serially over 5 days. Results Baseline plasma-free hemoglobin levels were equal in all three circuits. Circuit C had the greatest increase in plasma-free hemoglobin daily (26.3 mg/dL/day) compared to Circuit A and Circuit B, which were 14.1 mg/dL/day and 12.9 mg/dL/day, respectively. Conclusions Our data suggests that partially occluding clamps are not a significant contributor to hemolysis; rather, increased flow through the oxygenator significantly increased the rate of hemolysis in neonatal ECMO circuits.
Prognostic impact of oligometastases in orthopaedic surgery for metastatic bone disease
Authors: Weschenfelder Wolfram , Weschenfelder Friederike , Spiegel Christian , Schrenk Karin Gabriela , Ernst Thomas , Hofmann Gunther Olaf 
Published: February 2025

Introduction The rising number of cancer patients with metastatic bone disease (MBD) reflects advancements in treatment. The concept of oligometastatic disease, associated with improved prognosis, has emerged. This study evaluated prognostic factors, including oligometastases, in patients undergoing urgent orthopaedic surgery for MBD to inform preoperative decision-making and reduce morbidity and mortality from immobilization. Materials and Methods We retrospectively analysed records of patients who underwent surgery for MBD between 2005 and 2022. Data included medical history, tumour type, metastatic status, surgical method, lesion location, imaging, and survival outcomes. Multivariate survival analyses were conducted. Results The number of metastases and presence of visceral metastases significantly influenced survival. Patients with single metastases had a median survival of 65 months, oligometastases 25 months, and polymetastases 11 months. Visceral metastases were associated with a median survival of 9 months versus 27 months without. Tumour type also impacted prognosis, with thyroid cancer patients having the highest median survival and lung cancer patients the lowest. Pathological fractures reduced survival significantly (11 months vs 36 months without fractures). Conclusion Oligometastatic disease is a strong prognostic factor for MBD patients undergoing orthopaedic surgery, with better outcomes compared to polymetastatic disease. Other key factors include tumour type, visceral metastases, and pathological fractures. Improved staging, risk assessment, and early interdisciplinary collaboration could mitigate pathological fractures and improve outcomes.
Encephalopathy at High Altitude: Hyponatremia or High Altitude Cerebral Edema?
Authors: Brant-Zawadzki Graham , Hew-Butler Tamara , Youngquist Drew C. , Fiore David , Hackett Peter 
Published: February 2025

Objective Brain dysfunction at high altitudes can be caused by both high altitude cerebral edema (HACE) and hyponatremic encephalopathy. Differentiating them is important for proper treatment but can be difficult. We present a case series of 11 patients with hyponatremic encephalopathy, all initially misdiagnosed as HACE, and we discuss key signs and symptoms that will help clinicians differentiate the 2 pathologies. Methods We compiled 11 cases of patients with severe hyponatremia who were diagnosed with HACE, verified through direct patient care or referral consultation. Results Patients included 5 males and 6 females aged 19 to 65 y, exercising between 2100 and 4300 m. Serum Na+ concentration ranged from 112 to 127 mmol·L–1. Features included ataxia, confusion, and progression to coma without the hallmark imaging features of HACE. Clinically, the rapid progression of symptoms, moderate altitude, short duration of altitude exposure, and seizure activity suggested hyponatremia rather than HACE. All but 1 patient shared classic risk factors for exercise-associated hyponatremia: moderate to extreme exercise, rapid high volume (>5 L) fluid intake, clamminess, pallor, and nausea. Five patients suffered seizures, 4 used nonsteroidal anti-inflammatory medications, 4 had pulmonary edema, and 3 showed features of the syndrome of antidiuretic hormone secretion. Conclusions Severe hyponatremia should be considered in persons with encephalopathy at high altitudes. Although there is no established causal link between hypobaric hypoxia and hyponatremia, the potential for high altitude exposure to exacerbate exercise-associated hyponatremia warrants further investigation because the consequences of developing or misdiagnosing this process may be severe.
Blending Western and Australian Aboriginal Approaches: A Study Protocol for Codesign of Bicultural Teleoncology Models of Care in Remote Australian Communities
Authors: Webster Emma , Purcell-Khodr Gemma , Townsend Billie , Hall Allan , Hill Yvonne , See Cecil , Ward Katrina , Honeyball Florian 
Published: February 2025

Cancer treatments have failed to reach people who live in rural and remote Australia. Geographic constraints on service delivery are exacerbated for Aboriginal and Torres Strait Islander peoples who continue to be marginalised by a colonial legacy that drives disparities in access to healthcare. This is particularly evident in the remote communities of Bourke and Brewarrina which are home to significant Aboriginal populations. They are located 100 km apart and 400 km from the nearest cancer centre. We aim to codesign bicultural models of care to deliver a bespoke cancer service, enabling administration of low and medium risk chemotherapies via teleoncology in two remote Australian communities. Aboriginal philosophy and pedagogy will be used with Community-Led participatory research methods. Maximum variation and snowball sampling will ensure diversity of participants in the codesign. Up to 100 participants will contribute, with multiple data collection events held in each monthly data collection cycle. Data will be collected in individual or small group yarning style sessions and recorded on a visual template. Framework analysis will be used to map each round of data collection to consolidate visual models of cancer care for each town. This incremental data collection involves participants in cycles of analysis and interpretation. Both communities have study-specific Research Governance Groups with representation from Aboriginal and non-Aboriginal community members to guide investigators. This study approaches codesign by following Aboriginal cultural protocols. Ethical (axiology) and relational (ontological) processes precede intellectual (epistemology) and operational (methodology) processes. A direct outcome of this research will be provision of teleoncology aligned with the models in each community supported by the nearest regional cancer centre (Western Cancer Centre Dubbo). Another novel aspect is use of the Australian Bicultural Model of care which was first described in an alcohol treatment context and is tested here for transferability to other settings.
Delineating the Role of Inter-Repetition Interval in the Relationship between Maximum Repetitions to Failure or Repetitions in Reserve and Movement Velocity
Authors: Martínez-Rubio Carlos , Baena-Raya Andrés , Quidel-Catrilelbún Mauricio Elías Leandro , Rodríguez-Pérez Manuel A. , Pérez-Castilla Alejandro 
Published: February 2025

Background: Maximum repetitions to failure (RTF) and repetitions in reserve (RIR) can be estimated through fastest mean velocity (MVfastest) and mean velocity (MV), respectively. However, the impact of inter-repetition intervals (IRI) on these relationships in free-weight back squat and bench press exercises is unclear. Hypothesis: The IRI would affect RTF-MVfastest and RIR-MV relationships, with a higher goodness-of-fit using self-selected IRI (SSIRI) compared with 0 seconds (IRI0) and 3 seconds (IRI3). Study Design: Crossover study design. Level of Evidence: Level 3. Methods: Eighteen male participants completed 1 session per IRI configuration, consisting of 3 single sets of RTF (65%-75%-85% of the 1-repetition maximum) during the free-weight back squat and bench press exercises. Results: Individualized RTF-MVfastest and RIR-MV relationships were stronger than generalized (median R2 = 0.98 vs 0.65 and 0.84 vs 0.40, respectively). The goodness-of-fit of the relationships was stronger for SSIRI than for IRI0 during back squat ( P < .01) and comparable between IRIs during bench press ( P ≥ .28). During back squat, MVfastest values were higher for IRI0 than for IRI3 and SSIRI (eighth-fifteenth repetitions; P ≤ .07), whereas during the bench press, they were higher for IRI0 than for IRI3 (eleventh-fifteenth repetitions; P ≥ .28). Overall, MV values associated with each RIR were higher for IRI0 than for SSIRI (10 out of 18 comparisons) during back squat, and for IRI0 than for IRI3 and SSIRI (16 and 14 out of 18 comparisons) during bench press. Conclusion: These results highlight the importance of standardizing the IRI during set-to-failure to establish RTF-MVfastest and RIR-MV relationships, with SSIRI recommended as a more accurate and effective procedure. Clinical Relevance: This information may provide practitioners with a valuable tool to objectively quantify the level of effort being exerted during resistance training sets by measuring movement velocity in free-weight exercises.
Novel Noninvasive Imaging Techniques to Assess Structural, Functional, and Material Properties of Tendon, Ligament, and Cartilage: A Narrative Review of Current Concepts
Authors: Retzky Julia S. , Koff Matthew F. , Nwawka Ogonna K. , Rodeo Scott A. 
Published: February 2025

Background: Novel noninvasive imaging modalities such as quantitative magnetic resonance imaging (qMRI) and shear wave elastography (SWE) allow for assessment of soft tissue microstructure and composition, which ultimately may be associated with functional and material properties. Purpose: To provide a narrative review of the scientific techniques and clinical applications of qMRI and SWE for the evaluation of soft tissue about the knee and shoulder, including the meniscus, the anterior cruciate ligament (ACL), and the rotator cuff. Study Design: Review. Methods: A literature search was performed in October 2022 via PubMed using the following keywords: “quantitative MRI tendon,” quantitative MRI ligament,”“quantitative MRI cartilage,” or “shear wave elastography tendon.” Only articles related to clinical applications were included in this review. Results: Conventional imaging techniques, including standard morphologic magnetic resonance imaging (MRI) and ultrasound imaging, have limited ability to evaluate the material and functional properties of soft tissue; qMRI builds on the limitations of conventional morphologic MRI by allowing for detection of early articular cartilage changes, differentiation of healed versus unhealed meniscal tissue, and quantification of ACL graft maturity. SWE can evaluate the material properties of rotator cuff and Achilles tendons after injury, which may provide insight into both the chronicity and the healing status of the aforementioned injuries. Conclusion: Our review of the literature showed that quantitative imaging techniques, including qMRI and SWE, may both improve early detection of pathology and aid in comprehensive evaluation after treatment.
New Graduate Nurses’ Transition to Practice During the COVID-19 Pandemic: Voices of Clinical Nurse Educators From the Front Lines
Authors: Djukic Maja , Pine Rosemary , Short Yashamika , Jackson Joy , McVey Caitlin , Cline Daniel D. 
Published: February 2025

Introduction Although COVID-19 may no longer be a global public health emergency, it is imperative to continue to reflect on the lessons learned from it, especially from the front-line nurses and nurse educators, to ensure effective nursing workforce response to disasters and emergencies of all kinds. The COVID-19 pandemic has disproportionately affected the new graduate nurses (NGNs) by altering their transition to practice (TTP) experiences. Many studies have examined perceptions and voices of educators from nursing education programs and NGNs about their experiences of transitioning to practice during the pandemic. However, clinical nurse educators’ voices are lacking. Method This qualitative descriptive study explored clinical nurse educators’ perspectives on the differences in TTP before and during the pandemic. Results The preliminary results encompassed two themes No hands on and Used to interacting with mannequins that point to root causes of greater struggles NGNs who transitioned to practice during the pandemic faced compared to their pre-pandemic counterparts. Conclusion Safely maintaining clinical access to learners during public health emergencies will be imperative to ensure NGNs enter practice prepared to provide safe and high-quality care.
Program Evaluation in Competence by Design: A Mixed-Methods Study
Authors: Milosek Jenna , Eady Kaylee , Moreau Katherine A. 
Published: February 2025

BACKGROUND The evaluation of Competence by Design (CBD) residency programs is crucial for enhancing program effectiveness. However, literature on evaluating CBD programs is limited. We conducted a 2-phase mixed-methods study to (a) assess the extent of program evaluation activities in CBD residency programs in Canada, (b) explore reasons for engaging or not engaging in these activities, (c) examine how CBD programs are conducting program evaluations, and (d) identify ways to build capacity for program evaluation. METHODS Phase 1 involved surveying 149 program directors from specialty/subspecialty programs that transitioned to CBD between 2017 and 2020. We calculated descriptive statistics for 22 closed-ended survey items. Phase 2 comprised interviews with a subset of program directors from Phase 1. Data analysis followed a 3-step iterative process: data condensation, data display, and drawing and verifying conclusions. RESULTS In Phase 1, we received 149 responses, with a 33.5% response rate. Of these, 127 (85.2%) indicated their programs engage in evaluation, while 22 (14.8%) do not. Among the 127 programs that engage in evaluation, 29 (22.8%) frequently or always develop evaluation questions, and 23 (18.1%) design evaluation proposals/plans. Reasons for engaging in evaluation included decision-making and stimulating changes in educational practices. Conversely, reasons for not engaging included lack of knowledge, personnel, and funding. In Phase 2, 15 program directors were interviewed. They reported that CBD programs face challenges such as limited resources and buy-in, rely on ad hoc evaluation methods, and use a team-based evaluation format. To enhance evaluation capacities, interviewees suggested (a) developing expertise in program evaluation, (b) acquiring evaluation resources, and (c) advocating for clear evaluation expectations. CONCLUSIONS Most CBD residency programs are engaged in program evaluations, but the quality is often questionable. To fully realize the potential of program evaluation, CBD programs need additional resources and support to improve evaluation practices and outcomes.