bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drawing Parallels Among Past Public Health Crises and COVID-19
Authors: Contreras George W. , Burcescu Brigitte , Dang Tiffany , Freeman Jeanette , Gilbreth Nathan , Jacobson Juliet , Jayaseelan Keerthana , Markenson David S. 
Published: June 2021

AbstractIn the early stages of the coronavirus disease 2019 (COVID-19) pandemic, there were shortages of personal protective equipment (PPE) and health-care personnel across severely affected regions. Along with a lack of testing, these shortages delayed surveillance, and possible containment of the virus. The pandemic also took unprecedented tolls on the mental health of many health-care workers who treated and witnessed the deaths of critically ill patients. To address these effects and prepare for a potential second wave, a literature review was performed on the response of health-care systems during the influenza pandemics of 1918, 1957, 2009, and the epidemics of Ebola, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). We can use lessons identified to develop a competent and effective response to the current and future pandemics. The public must continue to engage in proper health mitigation strategies, including use of face coverings, physical distancing, and hand washing. The impact the pandemic has had on the mental health of frontline health-care workers cannot be disregarded as it is essential in ensuring effective patient care and mitigating psychological comorbidities. The lessons identified from past public health crises can help contain and limit morbidity and mortality with the ongoing COVID-19 pandemic.
Risk Stratification of Nursing Homes to Plan COVID-19 Responses: A Case Study of Victoria, Australia
Authors: Ibrahim Joseph E. , Li Yingtong , Brown Charlotte , McKee Grace , Eren Hagar , Pham Tony 
Published: June 2021

AbstractObjective:Emergency management responses to coronavirus disease 2019 (COVID-19) in nursing homes lacked preparation and nuance; moving forward, responses must recognize nursing homes are not generic organizations or services, and individually appreciate each’s unique nature, strengths, and limitations. The objective of this study was to describe an approach to stratifying nursing homes according to risk for COVID-19 outbreak.Methods:Population-based cross-sectional study of all accredited nursing homes in Victoria (n = 766), accommodating 48,824 permanent residents. We examined each home’s facility structure, governance history, socio-economic status, proximity to high-risk industry, and proximity and size of local acute public hospital, stratified by location, size, and organizational structure.Results:Privately owned nursing homes tend to be larger and metropolitan-based, and publicly owned homes regionally based and smaller in size. The details reveal additional nuance, eg, privately owned metropolitan-based medium- to large-sized facilities tended to have more regulatory noncompliance, no board of governance, and fewer Chief Executive Officers with clinical background. In contrast, the smaller, publicly owned, remote facilities perform better on those same metrics.Conclusions:Nursing homes should not be regarded as generic entities, and there is significant underlying heterogeneity. Stratification of nursing homes according to risk level is a viable approach to informing more nuanced policy direction and resource allocation for emergency management responses.
Disaster Training Following COVID-19 for Pediatric Medical Residents: Demand and Format
Authors: Boggs Kaitlyn , Goodwin Tress , Simpson Joelle 
Published: June 2021

AbstractObjectives:Assess the knowledge, confidence, and attitudes of residents toward disaster medicine education in the coronavirus disease 2019 (COVID-19) era.Methods:Survey distributed to pediatric residents at a tertiary care center, assessing confidence in disaster medicine knowledge and skills, and preferred educational methods. Based on residents’ responses, virtual and in-person educational session implemented with a postsurvey to analyze effectiveness of education.Results:Distributed to 120 residents with a 51.6% response rate. Almost half (46.8%) of residents had less than 1 h of disaster training, with only 9.7% having experience with a prior disaster event. However, most residents were motivated to increase their knowledge of disaster medicine due to COVID-19 and other recent disasters, with 96.8% interested in this education as a curriculum standard. Simulation and peer learning were the most preferred method of teaching. Subsequent virtual and in-person educational session demonstrated improvement in confidence scores. However, 66.7% of the virtual subset conveyed they would have preferred in-person learning.Conclusions:COVID-19 has highlighted to trainees that disasters can affect all specialties, and pediatric residents are enthusiastic to close the educational gap of disaster medicine. However, residents stressed that, although virtual education can provide a foundation, in-person simulation is preferred for effective training.
Design, installation and commissioning of the ELI-Beamlines high-power, high-repetition rate HAPLS laser beam transport system to P3
Authors: Borneis S. , Laštovička T. , Sokol M. , Jeong T.-M. , Condamine F. , Renner O. , Tikhonchuk V. , Bohlin H. , Fajstavr A. , Hernandez J.-C. , Jourdain N. , Kumar D. , Modřanský D. , Pokorný A. , Wolf A. , Zhai S. , Korn G. , Weber S. 
Published: June 2021

AbstractThe design and the early commissioning of the ELI-Beamlines laser facility’s 30 J, 30 fs, 10 Hz HAPLS (High-repetition-rate Advanced Petawatt Laser System) beam transport (BT) system to the P3 target chamber are described in detail. It is the world’s first and with 54 m length, the longest distance high average power petawatt (PW) BT system ever built. It connects the HAPLS pulse compressor via the injector periscope with the 4.5 m diameter P3 target chamber of the plasma physics group in hall E3. It is the largest target chamber of the facility and was connected first to the BT system. The major engineering challenges are the required high vibration stability mirror support structures, the high pointing stability optomechanics as well as the required levels for chemical and particle cleanliness of the vacuum vessels to preserve the high laser damage threshold of the dielectrically coated high-power mirrors. A first commissioning experiment at low pulse energy shows the full functionality of the BT system to P3 and the novel experimental infrastructure.
Swarm Observations of Dawn/Dusk Asymmetries Between Pedersen Conductance in Upward and Downward Field‐Aligned Current Regions
Authors: Olifer L. , Feltman C. , Ghaffari R. , Henderson S. , Huyghebaert D. , Burchill J. , Jaynes A. N. , Knudsen D. , McWilliams K. , Moen J. I. , Spicher A. , Wu J. 
Published: June 2021

AbstractThe locations of region 1 and 2 field‐aligned current systems were determined using fluxgate magnetometer measurements from 875 dawn‐dusk passes of the Swarm A satellite. Within each field‐aligned current region, the ionospheric Pedersen conductance was derived from the newly corrected Swarm electric and magnetic field measurements. The Pedersen conductances are generally consistent with photoionization models. However, we show that the in situ method of determining Pedersen conductance allows for a more complete description of magnetosphere‐ionosphere coupling and should be used in future studies when possible. We show that, overall, the Pedersen conductance is larger in the upward current region than in the downward region by ∼0.6 S on the dawn side of the Earth. Meanwhile, the dusk side Pedersen conductance is equivalent in both current regions. We attribute this asymmetry to dawn side energetic electron precipitation, commonly associated with substorm electron injections from the magnetotail.
Spatial Evolution of Wave‐Particle Interaction Region Deduced From Flash‐Type Auroras and Chorus‐Ray Tracing
Authors: Ozaki Mitsunori , Inoue Tomohiro , Tanaka Yoshimasa , Yagitani Satoshi , Kasahara Yoshiya , Shiokawa Kazuo , Miyoshi Yoshizumi , Imamura Kousuke , Hosokawa Keisuke , Oyama Shin‐ichiro , Kataoka Ryuho , Ebihara Yusuke , Ogawa Yasunobu , Kadokura Akira 
Published: June 2021

AbstractIn‐situ observations of spatial variations of the wave‐particle interaction region require a large number of satellite probes. As an alternative, flash‐type auroras, a kind of pulsating aurora, driven by discrete chorus elements, can be used to investigate the interaction region with a high spatial resolution. We estimated the spatial extent of wave‐particle interaction region from ground‐based observations of flash aurora at Gakona (62.39°N, 214.78°E), Alaska at subauroral latitudes, and found that the auroral expansion was predominantly to the low‐latitude side. The spatial displacement is thought to be caused by the propagation effects of chorus waves in the magnetosphere. Using ray tracing analysis to take into account chorus wave propagation, we reconstructed the spatiotemporal evolution of the volume emission rate and confirmed that the predominant expansion is toward the lower‐latitude side in the ionosphere. This study shows that chorus wave propagation in the magnetosphere gives new insight for characterizing the transverse size (across the geomagnetic field line) of wave‐particle interaction regions. The calculated spatial scale of the column auroral emission shows a correlation with the magnetic latitude of the resonance region at magnetic latitudes within 10° of the equatorial plane of the magnetosphere. Our results suggest that the spatial scale of a flash aurora is indirectly related to the chorus amplitude because the latitudinal range of the wave‐particle interaction is important for the growth of wave amplitude.
Maintenance power requirements of anammox bacteria “Candidatus Brocadia sinica” and “Candidatus Scalindua sp.”
Authors: Okabe Satoshi , Kamigaito Atsushi , Kobayashi Kanae 
Published: June 2021

Abstract
Little is known about the cell physiology of anammox bacteria growing at extremely low growth rates. Here, “Candidatus Brocadia sinica” and “Candidatus Scalindua sp.” were grown in continuous anaerobic membrane bioreactors (MBRs) with complete biomass retention to determine maintenance energy (i.e., power) requirements at near-zero growth rates. After prolonged retentostat cultivations, the specific growth rates (μ) of “Ca. B. sinica” and “Ca. Scalindua sp.” decreased to 0.000023 h−1 (doubling time of 1255 days) and 0.000157 h−1 (184 days), respectively. Under these near-zero growth conditions, substrate was continuously utilized to meet maintenance energy demands (me) of 6.7 ± 0.7 and 4.3 ± 0.7 kJ mole of biomass-C−1 h−1 for “Ca. B. sinica” and “Ca. Scalindua sp.”, which accorded with the theoretically predicted values of all anaerobic microorganisms (9.7 and 4.4 kJ mole of biomass-C−1 h−1at 37 °C and 28 °C, respectively). These me values correspond to 13.4 × 10−15 and 8.6 × 10−15 watts cell−1 for “Ca. B. sinica” and “Ca. Scalindua sp.”, which were five orders of magnitude higher than the basal power limit for natural settings (1.9 × 10−19 watts cells−1). Furthermore, the minimum substrate concentrations required for growth (Smin) were calculated to be 3.69 ± 0.21 and 0.09 ± 0.05 μM NO2− for “Ca. B. sinica” and “Ca. Scalindua sp.”, respectively. These results match the evidence that “Ca. Scalindua sp.” with lower maintenance power requirement and Smin are better adapted to energy-limited natural environments than “Ca. B. sinica”, suggesting the importance of these parameters on ecological niche differentiation in natural environments.
Thermodynamic non-ideality and disorder heterogeneity in actinide silicate solid solutions
Authors: Marcial J. , Zhang Y. , Zhao X. , Xu H. , Mesbah A. , Nienhuis E. T. , Szenknect S. , Neuefeind J. C. , Lin J. , Qi L. , Migdisov A. A. , Ewing R. C. , Dacheux N. , McCloy J. S. , Guo X. 
Published: June 2021

AbstractNon-ideal thermodynamics of solid solutions can greatly impact materials degradation behavior. We have investigated an actinide silicate solid solution system (USiO4–ThSiO4), demonstrating that thermodynamic non-ideality follows a distinctive, atomic-scale disordering process, which is usually considered as a random distribution. Neutron total scattering implemented by pair distribution function analysis confirmed a random distribution model for U and Th in first three coordination shells; however, a machine-learning algorithm suggested heterogeneous U and Th clusters at nanoscale (~2 nm). The local disorder and nanosized heterogeneous is an example of the non-ideality of mixing that has an electronic origin. Partial covalency from the U/Th 5f–O 2p hybridization promotes electron transfer during mixing and leads to local polyhedral distortions. The electronic origin accounts for the strong non-ideality in thermodynamic parameters that extends the stability field of the actinide silicates in nature and under typical nuclear waste repository conditions.
Classical variational simulation of the Quantum Approximate Optimization Algorithm
Authors: Medvidović Matija , Carleo Giuseppe 
Published: June 2021

AbstractA key open question in quantum computing is whether quantum algorithms can potentially offer a significant advantage over classical algorithms for tasks of practical interest. Understanding the limits of classical computing in simulating quantum systems is an important component of addressing this question. We introduce a method to simulate layered quantum circuits consisting of parametrized gates, an architecture behind many variational quantum algorithms suitable for near-term quantum computers. A neural-network parametrization of the many-qubit wavefunction is used, focusing on states relevant for the Quantum Approximate Optimization Algorithm (QAOA). For the largest circuits simulated, we reach 54 qubits at 4 QAOA layers, approximately implementing 324 RZZ gates and 216 RX gates without requiring large-scale computational resources. For larger systems, our approach can be used to provide accurate QAOA simulations at previously unexplored parameter values and to benchmark the next generation of experiments in the Noisy Intermediate-Scale Quantum (NISQ) era.
Preclinical study of a novel therapeutic vaccine for recurrent respiratory papillomatosis
Authors: Lee Maxwell Y. , Metenou Simon , Brough Douglas E. , Sabzevari Helen , Bai Ke , Jochems Caroline , Schlom Jeffrey , Allen Clint T. 
Published: June 2021

AbstractActivation of antigen-specific T-lymphocyte responses may be needed to cure disorders caused by chronic infection with low-risk human papillomavirus (lrHPV). Safe and effective adjuvant therapies for such disorders are needed. The safety and efficacy of a novel gorilla adenovirus vaccine expressing a protein designed to elicit immune responses directed against HPV6 and HPV11, PRGN-2012, was studied using in vitro stimulation of T lymphocytes from patients with recurrent respiratory papillomatosis, in vivo vaccination studies, and therapeutic studies in mice bearing tumors expressing lrHPV antigen. PRGN-2012 treatment induces lrHPV antigen-specific responses in patient T lymphocytes. Vaccination of wild-type mice induces E6-specific T-lymphocyte responses without toxicity. In vivo therapeutic vaccination of mice bearing established HPV6 E6 expressing tumors results in HPV6 E6-specific CD8+ T-lymphocyte immunity of sufficient magnitude to induce tumor growth delay. The clinical study of PRGN-2012 in patients with disorders caused by chronic infection with lrHPV is warranted.
Prediction model for early graft failure after liver transplantation using aspartate aminotransferase, total bilirubin and coagulation factor
Authors: Rhu Jinsoo , Kim Jong Man , Kim Kyunga , Yoo Heejin , Choi Gyu-Seong , Joh Jae-Won 
Published: June 2021

AbstractThis study was designed to build models predicting early graft failure after liver transplantation. Cox regression model for predicting early graft failure after liver transplantation using post-transplantation aspartate aminotransferase, total bilirubin, and international normalized ratio of prothrombin time was constructed based on data from both living donor (n = 1153) and deceased donor (n = 359) liver transplantation performed during 2004 to 2018. The model was compared with Model for Early Allograft Function Scoring (MEAF) and early allograft dysfunction (EAD) with their C-index and time-dependent area-under-curve (AUC). The C-index of the model for living donor (0.73, CI = 0.67–0.79) was significantly higher compared to those of both MEAF (0.69, P = 0.03) and EAD (0.66, P = 0.001) while C-index for deceased donor (0.74, CI = 0.65–0.83) was only significantly higher compared to C-index of EAD. (0.66, P = 0.002) Time-dependent AUC at 2 weeks of living donor (0.96, CI = 0.91–1.00) and deceased donor (0.98, CI = 0.96–1.00) were significantly higher compared to those of EAD. (both 0.83, P < 0.001 for living donor and deceased donor) Time-dependent AUC at 4 weeks of living donor (0.93, CI = 0.86–0.99) was significantly higher compared to those of both MEAF (0.87, P = 0.02) and EAD. (0.84, P = 0.02) Time-dependent AUC at 4 weeks of deceased donor (0.94, CI = 0.89–1.00) was significantly higher compared to both MEAF (0.82, P = 0.02) and EAD. (0.81, P < 0.001). The prediction model for early graft failure after liver transplantation showed high predictability and validity with higher predictability compared to traditional models for both living donor and deceased donor liver transplantation.
Life expectancy estimations and determinants of return to work among cancer survivors over a 7-year period
Authors: Chen Wei-Liang , Chen Yuan-Yuei , Wu Wei-Te , Ho Ching-Liang , Wang Chung-Ching 
Published: June 2021

AbstractDue to advances in medical science and technology, the number of cancer survivors continues to increase. The workplace needs and employment difficulties cancer survivors face after treatment need to be addressed to protect these individuals’ right to work and to maintain the overall labor force of the country. We conducted a retrospective cohort study with a follow-up period from 2004 to 2010. All data analyzed in the study were obtained from the Labor Insurance Database, the Taiwan Cancer Registry of the Ministry of Health and Welfare, and the National Health Insurance Research Database. The relationships between risk factors and the presence of returning to work were analyzed by a Cox proportional hazard model. The survival rates of patients with different cancer stages were evaluated using Kaplan–Meier survival analysis. Among the employees with an initial diagnosis of cancer, 70.4% remained employed through 1 year after the diagnosis, accounting for 83.4% of all cancer survivors; only 51.1% remained employed through 5 years after the diagnosis, accounting for 78.7% of all cancer survivors, a notable decrease. Age, gender, salary, treatment method, company size, and cancer stage were the factors that affected whether employees could return to work or not. The long-term survival of people diagnosed with cancer depends on their chances of returning to work. Strengthening existing return-to-work policies and assisting cancer survivors with returning to work after the treatment should be priorities for protecting these individuals’ right to work and for maintaining the overall labor force.
The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation
Authors: Norizadeh Abbariki Tannaz , Gonda Zita , Kemler Denise , Urbanek Pavel , Wagner Tabea , Litfin Margarethe , Wang Zhao-Qi , Herrlich Peter , Kassel Olivier 
Published: June 2021

AbstractThe process of myogenesis which operates during skeletal muscle regeneration involves the activation of muscle stem cells, the so-called satellite cells. These then give rise to proliferating progenitors, the myoblasts which subsequently exit the cell cycle and differentiate into committed precursors, the myocytes. Ultimately, the fusion of myocytes leads to myofiber formation. Here we reveal a role for the transcriptional co-regulator nTRIP6, the nuclear isoform of the LIM-domain protein TRIP6, in the temporal control of myogenesis. In an in vitro model of myogenesis, the expression of nTRIP6 is transiently up-regulated at the transition between proliferation and differentiation, whereas that of the cytosolic isoform TRIP6 is not altered. Selectively blocking nTRIP6 function results in accelerated early differentiation followed by deregulated late differentiation and fusion. Thus, the transient increase in nTRIP6 expression appears to prevent premature differentiation. Accordingly, knocking out the Trip6 gene in satellite cells leads to deregulated skeletal muscle regeneration dynamics in the mouse. Thus, dynamic changes in nTRIP6 expression contributes to the temporal control of myogenesis.
A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures
Authors: Diossy Miklos , Sztupinszki Zsofia , Borcsok Judit , Krzystanek Marcin , Tisza Viktoria , Spisak Sandor , Rusz Orsolya , Timar Jozsef , Csabai István , Fillinger Janos , Moldvay Judit , Pedersen Anders Gorm , Szuts David , Szallasi Zoltan 
Published: June 2021

AbstractPARP inhibitors are approved for the treatment of solid tumor types that frequently harbor alterations in the key homologous recombination (HR) genes, BRCA1/2. Other tumor types, such as lung cancer, may also be HR deficient, but the frequency of such cases is less well characterized. Specific DNA aberration profiles (mutational signatures) are induced by homologous recombination deficiency (HRD) and their presence can be used to assess the presence or absence of HR deficiency in a given tumor biopsy even in the absence of an observed alteration of an HR gene. We derived various HRD-associated mutational signatures from whole-genome and whole-exome sequencing data in the lung adenocarcinoma and lung squamous carcinoma cases from TCGA, and in a patient of ours with stage IVA lung cancer with exceptionally good response to platinum-based therapy, and in lung cancer cell lines. We found that a subset of the investigated cases, both with and without biallelic loss of BRCA1 or BRCA2, showed robust signs of HR deficiency. The extreme platinum responder case also showed a robust HRD-associated genomic mutational profile. HRD-associated mutational signatures were also associated with PARP inhibitor sensitivity in lung cancer cell lines. Consequently, lung cancer cases with HRD, as identified by diagnostic mutational signatures, may benefit from PARP inhibitor therapy.
Timed daily exercise remodels circadian rhythms in mice
Authors: Hughes Alun Thomas Lloyd , Samuels Rayna Eve , Baño-Otálora Beatriz , Belle Mino David Charles , Wegner Sven , Guilding Clare , Northeast Rebecca Catrin , Loudon Andrew Stewart Irvine , Gigg John , Piggins Hugh David 
Published: June 2021

AbstractRegular exercise is important for physical and mental health. An underexplored and intriguing property of exercise is its actions on the body’s 24 h or circadian rhythms. Molecular clock cells in the brain’s suprachiasmatic nuclei (SCN) use electrical and chemical signals to orchestrate their activity and convey time of day information to the rest of the brain and body. To date, the long-lasting effects of regular physical exercise on SCN clock cell coordination and communication remain unresolved. Utilizing mouse models in which SCN intercellular neuropeptide signaling is impaired as well as those with intact SCN neurochemical signaling, we examined how daily scheduled voluntary exercise (SVE) influenced behavioral rhythms and SCN molecular and neuronal activities. We show that in mice with disrupted neuropeptide signaling, SVE promotes SCN clock cell synchrony and robust 24 h rhythms in behavior. Interestingly, in both intact and neuropeptide signaling deficient animals, SVE reduces SCN neural activity and alters GABAergic signaling. These findings illustrate the potential utility of regular exercise as a long-lasting and effective non-invasive intervention in the elderly or mentally ill where circadian rhythms can be blunted and poorly aligned to the external world.