bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Parathyroidectomy on Normocalcemic Primary Hyperparathyroidism and the Role of Intraoperative PTH Measurement
Authors: Alameer Ehab , Omar Mahmoud , Hoof Marcus , Shalaby Hosam , Abdelgawad Mohamed , Zora Ghassan , Shama Mohamed , Kandil Emad 
Published: November 2021

Background Normocalcemic primary hyperparathyroidism (NCpHPT) and normohormonal primary hyperparathyroidism (NHpHPT) are recently recognized variants of primary hyperparathyroidism. Current guidelines for the management hyperparathyroidism recognize NCpHPT as one of the areas that are recommended for more research due to limited available data. Methods A retrospective review of patients who had parathyroidectomy between 2014 and 2019. We excluded patients with multiple endocrine neoplasia syndromes and secondary and tertiary hyperparathyroidism. Included patients were classified based on the biochemical profile into classic or normocalcemic hyperparathyroidism group. Collected data included demographics, preoperative localizing imaging, intraoperative parathyroid hormone levels, and postoperative cure rates. Results 261 patients were included: 160 patients in the classic and 101 patients in the normocalcemic group. Patients in the normocalcemic group had significantly more negative sestamibi scans (n = 58 [8.2%] vs 78 [51.3%], P = <.01), smaller parathyroid glands (mean weight 436.0 ± 593.0 vs 742.4 ± 1109.0 mg, P = .02), higher parathyroid hyperplasia rates (n = 51 [50.5%] vs 69 [43.1%]), and significantly higher intraoperative parathyroid hormone at 10 minutes (78.1 ± 194.6 vs 43.9 ± 62.4 1, P = .04). Positive predictive value of both intraoperative parathyroid hormone and cure rate was lower in the normocalcemic group (84.2% vs 95.7%) and (80.5% vs 95%), respectively. Conclusion Normocalcemic hyperparathyroidism is a challenging disease. Surgeons should be aware of the lower cure rate in this group, interpret intraoperative parathyroid hormone with caution, and have a lower threshold for bilateral neck exploration and 4 glands visualization.
Outcomes, Union Rate, and Complications After Operative and Nonoperative Treatments of Neer Type II Distal Clavicle Fractures: A Systematic Review and Meta-analysis of 2284 Patients
Authors: Uittenbogaard Sophie J. , van Es Laurian J.M. , den Haan Chantal , van Deurzen Derek F.P. , van den Bekerom Michel P.J. 
Published: November 2021

Background: As nonoperative treatment of Neer type II distal clavicle fractures is associated with nonunion rates up to 33%, operative treatment is frequently advocated. However, evidence is lacking regarding which operative treatment to perform and whether this is superior to nonoperative treatment in terms of functional outcome and complication rate. Purpose: (1) To evaluate which surgical technique in the treatment of Neer type II distal clavicle fractures is optimal with regard to patient-reported outcomes and union and complication rates. (2) To review nonoperatively treated patients. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of the literature and meta-analysis were performed on January 27, 2021, in PubMed, Embase, CENTRAL, CINAHL/EBSCO, Web of Science/Clarivate Analytics, and SPORTDiscus/EBSCO. The search included all studies regarding nonoperative and operative treatment of Neer type II distal clavicle fractures with a minimum of 20 patients and follow-up of 12 months. The primary and secondary outcomes were patient-reported outcome measures at 12 months and union, complication, and revision rates. Results: A total of 59 articles were included involving 2284 patients. Coracoclavicular fixation, hook plate, transacromial pins, alternative plate, tension band wire/K-wire, a combination of surgical techniques, and a nonoperative group were described. Hook plates showed lower Constant-Murley scores as compared with coracoclavicular fixation (standard mean difference, –0.77; 95% CI, –1.26 to –0.28; P = .002). However, no significant difference was seen when the hook plate was compared with the locking plate and tension band wire/K-wire groups, and no significant difference in union rate was seen among all operative treatment groups. Operatively treated patients had significantly higher union rates than patients treated nonoperatively (standard mean difference: 0.05; 95% CI, 0.01 to 0.37; P = .004). Conclusion: Patients treated with hook plates showed significantly lower Constant-Murley scores and higher complication and revision rates as compared with those treated with coracoclavicular fixation, without differences in union rate. Higher Constant-Murley scores were seen in those patients with supplemental coracoclavicular fixation when using locking. Nonoperatively treated patients showed good functional outcome despite the 31% nonunion rate, although future studies are necessary to substantiate this conclusion. When using a locking plate, additional craniocaudal fixation showed significant better functional outcome.
Individual Experience and Engagement in Avatar-Mediated Environments: The Mediating Effect of Interpersonal Attraction
Authors: Alblehai Fahad M. 
Published: November 2021

The application of different virtual reality interventions has been recently gaining interest from researchers and practitioners. Due to the current COVID-19 pandemic, higher education institutions increased the use of these technologies to help create much value for educators and students. The relationship between individual experience and engagement in avatar-mediated environments has garnered empirical support, but still little is known about the mediating mechanisms underlying this relation. This study investigated the mediating role of interpersonal attraction (e.g., social, physical, and task attraction) in the link between individual experience and engagement in an avatar-mediated learning environment. A total of 112 participants (21–23 years; 73 male and 39 female) participated in online peer learning sessions in Second Life. After controlling for demographic covariates, the results showed that (1) individual experience was positively associated with students’ engagement; (2) social, physical, and task attraction was found to positively mediate the link between experience and engagement. The outcomes from this study provide valuable implications for promoting online learners’ engagement in avatar-mediated environments.
Multi-resBind: a residual network-based multi-label classifier for in vivo RNA binding prediction and preference visualization
Authors: Zhao Shitao , Hamada Michiaki 
Published: November 2021

Abstract
Background
Protein-RNA interactions play key roles in many processes regulating gene expression. To understand the underlying binding preference, ultraviolet cross-linking and immunoprecipitation (CLIP)-based methods have been used to identify the binding sites for hundreds of RNA-binding proteins (RBPs) in vivo. Using these large-scale experimental data to infer RNA binding preference and predict missing binding sites has become a great challenge. Some existing deep-learning models have demonstrated high prediction accuracy for individual RBPs. However, it remains difficult to avoid significant bias due to the experimental protocol. The DeepRiPe method was recently developed to solve this problem via introducing multi-task or multi-label learning into this field. However, this method has not reached an ideal level of prediction power due to the weak neural network architecture.

Results
Compared to the DeepRiPe approach, our Multi-resBind method demonstrated substantial improvements using the same large-scale PAR-CLIP dataset with respect to an increase in the area under the receiver operating characteristic curve and average precision. We conducted extensive experiments to evaluate the impact of various types of input data on the final prediction accuracy. The same approach was used to evaluate the effect of loss functions. Finally, a modified integrated gradient was employed to generate attribution maps. The patterns disentangled from relative contributions according to context offer biological insights into the underlying mechanism of protein-RNA interactions.

Conclusions
Here, we propose Multi-resBind as a new multi-label deep-learning approach to infer protein-RNA binding preferences and predict novel interactions. The results clearly demonstrate that Multi-resBind is a promising tool to predict unknown binding sites in vivo and gain biology insights into why the neural network makes a given prediction.
Changes in Australian community perceptions of non-communicable disease prevention: a greater role for government?
Authors: Grunseit Anne C. , Howse Eloise , Bohn-Goldbaum Erika , Mitchell Jo , Bauman Adrian E. 
Published: November 2021

Abstract
Background
Monitoring trends in community opinion can identify critical opportunities to implement upstream health policies or interventions. Our study examines change and demographic modifiers of change in community perceptions of government intervention for prevention of lifestyle-related chronic disease across two time points in Australia.

Methods
Data were drawn from the 2016 (n = 2052) and 2018 (n = 2601) waves of a nationally representative cross-sectional telephone survey, ‘AUSPOPS’. Survey questions gauged perceptions of government intervention for health in general, peoples’/organizations’ role in maintaining health (e.g., parents, government) and support for specific health interventions (e.g., taxing soft drink).
Bivariate and multivariate regression models tested for change between the two surveys, adjusted for demographic characteristics. Models with interactions between survey wave and demographic variables tested for differential change. One-tailed variance ratio tests examined whether opinions had become more polarized in 2018 compared with 2016.

Results
The large, significant increase observed in the perceived size of the role that government has in maintaining people’s health was uniform across demographic subpopulations. The role for employers and private health insurers was also perceived to be larger in 2018 compared with 2016, but the degree of change varied by gender, age and/or socioeconomic status. Support for some government interventions (e.g., taxing soft drinks) increased among specific demographic subgroups whilst exhibiting no overall change. Opinion was more polarized on general attitudes to government intervention for population health in 2018 compared to 2016, despite little change in central tendency.

Conclusions
Opportunities may exist to implement government health-promoting policies (e.g., taxing soft drinks), although advocacy may be needed to address the concerns of less supportive subpopulations. Attitudes on government intervention in general may be becoming more polarized; future research examining the association of such changes with exposure to different information sources could inform communication strategies for future health policy change.
Strengthening the role of community health workers in supporting the recovery of ill, undernourished children post hospital discharge: qualitative insights from key stakeholders in Bangladesh and Kenya
Authors: Njeru Rita Wanjuki , Uddin Md. Fakhar , Zakayo Scholastica Mutheu , Sanga Gladys , Charo Anderson , Islam Md. Aminul , Hossain Md. Alamgir , Kimani Mary , Mwadhi Mercy Kadzo , Ogutu Michael , Chisti Mohammod Jobayer , Ahmed Tahmeed , Walson Judd L. , Berkley James A. , Jones Caroline , Theobald Sally , Muraya Kui , Sarma Haribondhu , Molyneux Sassy 
Published: November 2021

Abstract
Background
Undernourished children in low- and middle-income countries remain at elevated risk of death following hospital discharge, even when treated during hospitalisation using World Health Organisation recommended guidelines. The role of community health workers (CHWs) in supporting post-discharge recovery to improve outcomes has not been adequately explored.

Methods
This paper draws on qualitative research conducted as part of the Childhood Acute Illnesses and Nutrition (CHAIN) Network in Bangladesh and Kenya. We interviewed family members of 64 acutely ill children admitted across four hospitals (a rural and urban hospital in each country). 27 children had severe wasting or kwashiorkor on admission. Family members were interviewed in their homes soon after discharge, and up to three further times over the following six to fourteen months. These data were supplemented by observations in facilities and homes, key informant interviews with CHWs and policy makers, and a review of relevant guidelines.

Results
Guidelines suggest that CHWs could play a role in supporting recovery of undernourished children post-discharge, but the mechanisms to link CHWs into post-discharge support processes are not specified. Few families we interviewed reported any interactions with CHWs post-discharge, especially in Kenya, despite our data suggesting that opportunities for CHWs to assist families post-discharge include providing context sensitive information and education, identification of danger signs, and supporting linkages with community-based services and interventions. Although CHWs are generally present in communities, challenges they face in conducting their roles include unmanageable workloads, few incentives, lack of equipment and supplies and inadequate support from supervisors and some community members.

Conclusion
A multi-pronged approach before or on discharge is needed to strengthen linkages between CHWs and children vulnerable to poor outcomes, supported by clear guidance. To encourage scale-ability and cost-effectiveness of interventions, the most vulnerable, high-risk children, should be targeted, including undernourished children. Intervention designs must also take into account existing health worker shortages and training levels, including for CHWs, and how any new tasks or personnel are incorporated into hospital and broader health system hierarchies and systems. Any such interventions will need to be evaluated in carefully designed studies, including tracking for unintended consequences.
Characterization and reverse genetic establishment of cattle derived Akabane virus in China
Authors: Chen Dongjie , Wang Di , Wei Fang , Kong Yufang , Deng Junhua , Lin Xiangmei , Wu Shaoqiang 
Published: November 2021

Abstract
Background
Akabane virus (AKAV) is an important insect-borne virus which is widely distributed throughout the world except the Europe and is considered as a great threat to herbivore health.

Results
An AKAV strain defined as TJ2016 was firstly isolated from the bovine sera in China in 2016. Sequence analysis of the S and M segments suggested that the isolated AKAV strain was closely related to the AKAV strains JaGAr39 and JaLAB39, which belonged to AKAV genogroup II. To further study the pathogenic mechanism of AKAV, the full-length cDNA clone of TJ2016 S, M, and L segment was constructed separately into the TVT7R plasmid at the downsteam of T7 promoter and named as TVT7R-S, TVT7R-M, and TVT7R-L, respectively. The above three plasmids were further transfected into the BSR-T7/5 cells simultaneously with a ratio of 1:1:1 to produce the rescued virus AKAV. Compared with the parental wild type AKAV (wtAKAV), the rescued virus (rAKAV) was proved to be with similar cytopathic effects (CPE), plaque sizes and growth kinetics in BHK-21 cells.

Conclusion
We successfully isolated a AKAV strain TJ2016 from the sera of cattle and established a reverse genetic platform for AKAV genome manipulation. The established reverse genetic system is also a powerful tool for further research on AKAV pathogenesis and even vaccine studies.
Enhanced recovery after surgery protocol and postoperative opioid prescribing for cesarean delivery: an interrupted time series analysis
Authors: Langnas E. M. , Matthay Z. A. , Lin A. , Harbell M. W. , Croci R. , Rodriguez-Monguio R. , Chen C. L. 
Published: November 2021

Abstract
Introduction
Enhanced recovery after surgery (ERAS) pathways have emerged as a promising strategy to reduce postoperative opioid use and decrease the risk of developing new persistent opioid use in surgical patients. However, the association between ERAS implementation and discharge opioid prescribing practices is unclear.

Study design
We conducted a retrospective observational quasi-experimental study of opioid-naïve patients aged 18+ undergoing cesarean delivery between February 2015 and December 2019 at a large academic center. An interrupted time series analysis (ITSA) was used to model the changes in pain medication prescribing associated with the implementation of ERAS to account for pre-existing temporal trends.

Results
Among the 1473 patients (out of 2249 total) who underwent cesarean delivery after ERAS implementation, 80.72% received a discharge opioid prescription vs. 95.36% at baseline. Pre-ERAS daily oral morphine equivalents (OME) on the discharge prescription decreased by 0.48 OME each month (p<0.01). There was a level shift of 35 more OME prescribed (p<0.01), followed by a monthly decrease of 1.4 OMEs per month after ERAS implementation (p<0.01). Among those who received a prescription, 61.35% received a total daily dose greater than 90 OME compared to 11.35% pre-implementation (p<0.01), while prescriptions with a total daily dose less than 50 OME decreased from 79.86 to 25.85% after ERAS implementation(p<0.01).

Conclusion
Although ERAS implementation reduced the overall proportion of patients receiving a discharge opioid prescription after cesarean delivery, for the subset of patients receiving an opioid prescription, ERAS implementation may have inadvertently increased the prescribing of daily doses greater than 90 OME. This finding highlights the importance of early and continued evaluation after new policies are implemented.
Nutrient resorption strategies of three oak tree species in response to interannual climate variability
Authors: Du Baoming , Ji Huawei , Liu Shirong , Kang Hongzhang , Yin Shan , Liu Chunjiang 
Published: November 2021

Abstract
Background
Nutrient resorption is critical for plants toward balancing their nutritional requirements and adapting to environmental variabilities, which further impacts litter quality and nutrient cycling. However, the interannual variability of nutrient resorption under climate change remains unclear.

Methods
We investigated the five-year nutrient resorption efficiencies (NuRE, %) of 14 elements in three deciduous oak tree species (Quercus aliena var. acuteserrata, Q. glandulifera, and Q. variabilis) in a warm-temperate forest of Central China and assessed their relationships with interannual climate and soil factors.

Results
Nutrient resorption did not differ between species but varied significantly between different years. For each year, N, P, S, K, C, Mg, and Zn were preferentially resorbed in all of the oak species in contrast to Ca, Na, Mn, Ba, Al, Fe, Cu, which were to some extent discriminated. Among the 14 elements, the NuRE of C, N, P, S, Ca, and Mg was more sensitive to interannual climate variations in the three oak species. The carbon resorption efficiency was significantly increased during the driest year of the study (2014); N resorption efficiency was reduced with temperature; whereas N and P resorption efficiency initially decreased and then increased with precipitation. Moreover, the elements with higher NuREs typically had lower coefficient of variation (CV) in all three oak species.

Conclusions
Different oak species exhibited analogous nutrient conservation strategies in response to annual climate variabilities, and interannual climate variations strongly impacted plant nutrient resorption. Deciduous plants may establish a tradeoff mechanism to rebalance somatic nutrients for regrowth at the end of the growing season.
Thermo physiological comfort of single jersey knitted fabric derivatives
Authors: Mishra Rajesh , Jamshaid Hafsa , Yosfani Sheraz Hussain Siddique , Hussain Uzair , Nadeem Muhammad , Petru Michal , Tichy Martin , Muller Miroslav 
Published: November 2021

AbstractThe main aim of this study is to determine the thermo-physiological comfort properties of single knit fabrics and their derivatives. As the Single Jersey knitted fabrics are the most widely used fabrics in the apparel sector, they have been selected for the analysis purpose. Derivatives of single jersey are developed and compared in order to understand the influence of structural variations. Physical properties e.g. thickness and areal density were evaluated for all knitted fabrics with 100% cotton yarn having three different yarn linear densities and after different stages of relaxation. Various thermo-physiological properties have been studied by changing the combed cotton yarn linear density as well as the structure of single knit fabric. Air permeability, thermal insulation and relative water vapor permeability of the fabrics were observed and investigated under wet relaxed states. It is determined that fabric physical properties are affected by changing yarn linear density and by the dry or wet relaxation stages. The percentage/number of tuck stitches (NTS), location of tuck stitches (LTS) and ratio of tuck to knit stitches (RTKS) have strong influence on physical and thermo-physiological properties of single knit fabrics, even though other knitting parameters remained the same.
Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis
Authors: Ramanauskaite Ausra , Fretwurst Tobias , Schwarz Frank 
Published: November 2021

AbstractPurposeTo evaluate the efficacy of alternative or adjunctive measures to conventional non-surgical or surgical treatment of peri-implant mucositis and peri-implantitis.Material and methodsProspective randomized and nonrandomized controlled studies comparing alternative or adjunctive measures, and reporting on changes in bleeding scores (i.e., bleed0ing index (BI) or bleeding on probing (BOP)), probing depth (PD) values or suppuration (SUPP) were searched.ResultsPeri-implant mucositis: adjunctive use of local antiseptics lead to greater PD reduction (weighted mean difference (WMD) = − 0.23 mm;p = 0.03, respectively), whereas changes in BOP were comparable (WMD = − 5.30%;p = 0.29). Non-surgical treatment of peri-implantitis: alternative measures for biofilm removal and systemic antibiotics yielded higher BOP reduction (WMD = − 28.09%;p = 0.01 and WMD = − 17.35%;p = 0.01, respectively). Surgical non-reconstructive peri-implantitis treatment: WMD in PD amounted to − 1.11 mm favoring adjunctive implantoplasty (p = 0.02). Adjunctive reconstructive measures lead to significantly higher radiographic bone defect fill/reduction (WMD = 56.46%;p = 0.01 and WMD = − 1.47 mm;p = 0.01), PD (− 0.51 mm;p = 0.01) and lower soft-tissue recession (WMD = − 0.63 mm;p = 0.01), while changes in BOP were not significant (WMD = − 11.11%;p = 0.11).ConclusionsAlternative and adjunctive measures provided no beneficial effect in resolving peri-implant mucositis, while alternative measures were superior in reducing BOP values following non-surgical treatment of peri-implantitis. Adjunctive reconstructive measures were beneficial regarding radiographic bone-defect fill/reduction, PD reduction and lower soft-tissue recession, although they did not improve the resolution of mucosal inflammation.