bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstructural features of subchondral radiolucent lesions in the medial femoral condyle of juvenile Thoroughbreds: A microcomputed tomography and histological analysis
Authors: Lemirre Thibeaut , Santschi Elizabeth M. , Girard Christiane A. , Fogarty Ursula , Janes Jennifer G. , Richard Helene , Laverty Sheila 
Published: June 2021

AbstractBackgroundThe aetiology of equine medial femoral condyle (MFC) subchondral bone radiolucencies (SR) is unknown.ObjectivesCharacterise the microstructural structural features of MFC SR in juvenile Thoroughbreds with microcomputed tomography (μCT) and histology.Study designCross‐sectional post‐mortem study.MethodsDistal femurs were collected at post‐mortem. Conventional tomodensitometry was employed to scout for MFCs with and without SR lesions (SR+ and SR−, respectively). Group 1 were CT MFC SR+ and Group 2 age‐matched SR− controls. Both underwent μCT and histological analysis. Group 3 CT MFC SR− foals, <6 months, were selected to search for chondronecrosis. Histological sections, processed from the lesion (Group 1) and a corresponding site in Groups 2 and 3, were assessed for chondronecrosis, fibrin, fibroplasia and osteochondral separation. Group 3 sections were surveyed for chondronecrosis alone.ResultsA total of 178 femurs from 89 Thoroughbreds were harvested. Of these horses 19.1% (95% CI: 10.9%‐27.3%) were CT MFC SR+ (17/23; 7.46 ± 4.36 months) and met the inclusion criteria for Group 1. Group 2 included 30 CT MFC SR− specimens (5.00 ± 2.73 months) and Group 3 had 44 CT MFC SR− s (2.68 ± 1.74 months). SR were located axially in foals <7 months of age, and centrally thereafter. All SRs had areas of thickened cartilage on histology and separation at the osteochondral junction containing fibrin (acute event) and fibroplasia (chronicity) in 73.9% (17/23; 95% CI: 56%‐91.9%). In Group 1 specimens, chondronecrosis was present in 82.6% (19/23; 95% CI: 67.1%‐98.1%) but four MFC SR+ had no evidence of chondronecrosis. Chondronecrosis was not detected in the Group 3 foal MFCs.Main limitationsNo longitudinal follow‐up.ConclusionsThe absence of chondronecrosis, pathognomic of osteochondrosis, in four MFC SR+s and in all of the CT MFC SR− foals suggests that osteochondrosis is not the cause, or the only cause, of these lesions and favours trauma as an alternate aetiological hypothesis.
Identification and analysis of stem‐specific promoters from sugarcane and energy cane for oil accumulation in their stems
Authors: Wang Jiang , Li Yaxin , Wai Ching Man , Beuchat Gabriel , Chen Li‐Qing 
Published: June 2021

AbstractConsiderable recent progress has been achieved in bioengineering oil accumulation in the vegetative tissues of plants, opening an opportunity for large scale production of biodiesel, jet fuel, lubricants, and high‐value lipid bioproducts. For the highly productive C4 crops, such as sugarcane, energy cane, Miscanthus, and fiber sorghums, the bulk of the biomass is the stem. However, little success has been made in accumulating oil in the stem. Since engineering a trait with a constitutive promoter often results in pleiotropic effects that counter trait improvement, identification of stem parenchyma‐specific promoters is a prerequisite for efficient use of the ample photoassimilates stored in mature stem parenchyma cells. In this study, we first identified two TST genes encoding homologues of tonoplast sugar transporters that were strongly and almost exclusively expressed in the stems of canes via a combination of RNA‐seq atlas analysis, in silico analysis of a sugarcane genome, phylogenetic analysis, and quantitative PCR analysis. They were further confirmed in the pith parenchyma cells of the mature stem by RNA in situ hybridization. When fused with the β‐Glucuronidase (GUS) reporter gene, the promoters of two alleles, TST2b‐1A and TST2b‐1C, from one TST gene demonstrated that they could drive the GUS expression exclusively in the stem in Arabidopsis.
The B‐Natural study—The outcome of immune tolerance induction therapy in patients with severe haemophilia B
Authors: Astermark Jan , Holstein Katharina , Abajas Yasmina L. , Kearney Susan , Croteau Stacy E. , Liesner Riana , Funding Eva , Kempton Christine L. , Acharya Suchitra , Lethagen Stefan , LeBeau Petra , Bowen Joel , Berntorp Erik , Shapiro Amy D. 
Published: June 2021

AbstractIntroductionInhibitors develop less frequently in haemophilia B (HB) than haemophilia A (HA). However, when present, the success of tolerization by immune tolerance induction (ITI) therapy is lower and the risk of complications higher.AimTo evaluate the use and outcome of ITI in patients with HB and inhibitors.MethodsSubjects include singletons or siblings with a current/history of inhibitors enrolled in B‐Natural—an observational study designed to increase understanding of clinical management of patients with HB. Patients were followed for 6 months and information on demographics, medical and social history, and treatment were recorded.ResultsTwenty‐nine patients with severe HB and inhibitors were enrolled in 24 centres. Twenty‐two underwent one or more courses of ITI with or without immune suppression. Eight patients (36.4%) were successfully tolerized after the first course of ITI. One of these successes (12.5%) experienced allergic manifestations, whereas the corresponding number for the 10 treatment failures was five (50%). One of seven (14.2%) patients with large deletions and three of eight (37.5%) with nonsense mutations were tolerized at the first attempt, and all patients experiencing nephrosis either failed or were on‐going. At study end, 11 (50%) were considered successfully tolerized after one or more ITI courses, three were unsuccessful, and eight were still undergoing treatment.ConclusionOur data underscore the possibilities and difficulties of achieving tolerization in patients with HB with inhibitors. The type of mutation and complications appear to correlate with ITI outcome, but more accurate definitions of successful ITI are warranted.
Understanding young adults’ reasons for seeking ‘clinically unnecessary’ urgent and emergency care: A qualitative interview study
Authors: Long Jaqui , Knowles Emma , Bishop‐Edwards Lindsey , O’Cathain Alicia 
Published: June 2021

AbstractBackgroundStudies have identified young adults as more likely to use emergency departments for ‘clinically unnecessary’ problems, with limited similar evidence for emergency ambulance use. Media portrayals depict young adults as motivated by ‘convenience’, but little research has explored the reasons for their help‐seeking behaviour.MethodsQualitative interviews with 16 young adults (18‐30) considered by clinicians to have made unnecessary use of emergency ambulance, emergency department or an urgent GP appointment. Data analysis was informed by interpretive phenomenological analysis.FindingsA number of interrelated factors contributed to participants’ decisions. They were anxious about the seriousness of their symptoms, sometimes exacerbated by reduced coping capacity due to poor mental health or life stresses. They looked to others to facilitate their decision making, who sometimes encouraged urgent contact. They wanted to avoid impact on existing day‐to‐day commitments including work or study. They had strong views about different health services, sometimes based on frustration with lack of resolution of on‐going health problems. Convenience was not identified as a significant factor, although some actions could be interpreted in this light if the context was not considered.ConclusionsYoung adults make ‘clinically unnecessary’ use of urgent and emergency care for more than convenience. Their decisions need to be understood in relation to the complexity of their experience, including lack of confidence in making health‐related decisions, lowered coping capacity and concern to maintain normal daily life.
Prognostic impacts of peripheral blood erythroblasts after single‐unit cord blood transplantation
Authors: Kaito Yuta , Konuma Takaaki , Monna‐Oiwa Maki , Kato Seiko , Isobe Masamichi , Okabe Motohito , Imai Yoichi , Takahashi Satoshi , Tojo Arinobu 
Published: June 2021

AbstractIntroductionThe appearance of erythroblasts (EBLs) in peripheral blood occurs in a variety of serious conditions and has been associated with mortality in critically ill patients. However, the incidence, risk factor, and outcomes of EBLs after cord blood transplantation (CBT) remain unclear.MethodsWe have investigated the impact of EBLs on transplant outcomes on 225 adult patients who underwent single‐unit CBT at our single institute.ResultsThe cumulative incidences of EBL ≥200 × 106/L and EBL ≥1000 × 106/L at 60 days after CBT were 17% and 4%, respectively, detected after a median of 35 days and 36.5 days. Multivariate analysis using erythroblastosis as time‐dependent covariates demonstrated the significant association of EBL ≥1000 × 106/L, but not EBL ≥200 × 106/L, with the development of grade III‐IV acute graft‐versus‐host disease (GVHD, hazard ratio [HR]: 18.56; P < .001), higher nonrelapse mortality (HR: 13.38; P < .001), and overall mortality (HR: 4.97; P = .001).ConclusionThese data suggested that higher levels of EBLs were recognized as a significant risk factor for severe acute GVHD and mortality after single‐unit CBT. Higher levels of EBLs may serve as a surrogate marker for poor single CBT outcomes.
A practical toolkit to support Australian mental health clinicians to manage Metabolic Syndrome: A pilot study
Authors: Porter Cassandra , Aggar Christina 
Published: June 2021

AbstractMetabolic syndrome (MetS) results in poor physical health outcomes and reduced life expectancy of up to 20 years less for people living with severe mental illness. The aim of this pilot study was to evaluate a locally developed practical toolkit (Let’s Get Physical‐Improved Physical Health in Mental Health Services‐A Practical Toolkit) to support mental health clinicians to manage MetS. The study explored clinician’s knowledge and attitudes towards managing MetS, confidence to screen for and intervene in MetS, and improvement in documentation. A longitudinal prospective study, utilizing audit and pre–post‐questionnaire design, was conducted. Of the 60 clinicians who were employed in the regional inpatient unit, 65% (n = 39) participated in at least one of the intervention education sessions. The final sample comprised 17 clinicians with matched pre‐ and post‐intervention data (28% of eligible participants). A total of 80 (20 per month) eMR metabolic monitoring form and patient file audits were conducted. Whilst the results were not statistically significant, this study found an overall improvement in clinicians’ knowledge of, and confidence to screen for and intervene in, MetS. Attitude scores were overall positive. There was also overall improvement in MetS documentation. The implementation of the practical evidence‐informed physical health in mental health services toolkit may have a positive impact on clinician knowledge, attitudes, and confidence in screening and intervening in MetS. Replicating this study with a larger sample is recommended.
Coping strategies in health care providers as second victims: A systematic review
Authors: Kappes Maria , Romero‐García Marta , Delgado‐Hito Pilar 
Published: June 2021

AbstractAimTo analyze personal and organizational strategies described in the literature for dealing with the second victim phenomenon among healthcare providers.BackgroundThe second victim phenomenon involves many associated signs and symptoms, which can be physical, psychological, emotional, or behavioral. Personal and organizational strategies have been developed to deal with this phenomenon.Materials and methodsA systematic review was carried out in PubMed, Cochrane Library, Web of Science, Scopus, PsycINFO, Science Direct, and Cumulative Index to Nursing and Allied Health Literature databases, searching for evidence published between 2010 and 2019 in Spanish, English, German, and Portuguese.ResultsSeven hundred and eighty‐three articles were identified. After eliminating duplicates, applying inclusion and exclusion criteria and critical analysis tools of the Joanna Briggs Institute, 16 research articles were included: 10 quantitative studies (design: descriptive, correlational, systematic, or integrative review) and six qualitative studies (descriptive, systematic review). There are several different personal and organizational strategies for dealing with the second victim phenomenon. Among these, peer support and learning from adverse events are highly valued. In personal strategies stands out the internal analysis of the adverse event that the professional performs to deal with the generated negative feelings. In organizational strategies, the most valued are second victim support programs with rapid response teams and made up of peers.ConclusionsThe main organizational coping strategies for tackling this phenomenon are online programs in countries such as the United States, Spain, and other European countries. Formal evaluation of these programs and research is required in Latin America.Implications for nursing and health policiesAdequately coping with the second victim phenomenon allows health professionals and organizations to learn from adverse events. Furthermore, by supporting health professionals who suffer from the second victim phenomenon, the organization takes care of its most valuable resource, its human capital. This contributes toward building a culture of healthcare quality in organizations, which will reduce adverse events in the future.
The effectiveness of preoperative stoma site marking on patient outcomes: A systematic review and meta‐analysis
Authors: Kim Young Man , Jang Hyun Jin , Lee Yun Jin 
Published: June 2021

AbstractAimsThis study systematically reviews the literature regarding preoperative stoma site marking and discusses the effectiveness of the procedure on complication rates, self‐care deficits and health‐related quality of life (HRQOL).DesignSystematic review and meta‐analysis.Data sourceOur review was conducted following the PRISMA guidelines. PubMed, EMBASE, Cochrane and CINAHL databases were searched to obtain articles published in English. Articles were also retrieved from Korean databases as well. Our last search was conducted on 2 June 2019.Review methodsTwo reviewers independently selected relevant studies, evaluated their methodological quality and extracted data. Experimental and observational studies were included. Our main focus was on complication rates, self‐care deficits and HRQOL. We conducted meta‐analysis using the statistical software spss 25.0 and Stata 13.0.ResultsOf the 1,039 articles reviewed, 20 were included for review, and 19 were used for quantitative synthesis. Preoperative stoma site marking reduced complication rates (odds ratio [OR]: 0.47; 95% confidence interval [CI]: 0.36–0.62; I2: 70.6%), lowered self‐care deficits (OR: 0.34; 95% CI: 0.18–0.64; I2: 0%), and increased HRQOL (standardized mean difference, 1.05; 95% CI: 0.70–1.40; I2: 0%). Quality appraisal results for both the individual studies and the studies overall were excellent. The possibility of publication bias was low.ConclusionsOur findings indicate that preoperative stoma site marking improves patient outcomes: stoma‐related complication rates and self‐care deficits decrease and HRQOL rises. For this reason, preoperative stoma site marking should be a mandatory procedure in clinical settings. The practice should also be supported by policymakers and healthcare expert associations.ImpactPreoperative stoma site marking reduces overall complication rates by 53% and skin problems by 59%. Preoperative stoma site marking also improves self‐care and health‐related quality of life. We recommend that preoperative stoma site marking should be a mandatory procedure in clinical settings.
Nurse turnover: A longitudinal survival analysis of the Korea Nurses' Health Study
Authors: Kim Young Taek , Kim Oksoo , Cha Chiyoung , Pang Yanghee , Sung Choa 
Published: June 2021

AbstractAimsTo identify factors influencing turnover among Korean female nurses from a longitudinal perspective.DesignA national cohort study called the Korea Nurses’ Health Study (2013–2020) was used.MethodsA national sample of female nurses from module 1 (N = 20,613, 2013–2014), module 5 (N = 11,527, 2016–2017), module 7 (N = 8,658, 2018–2019) and module 8 (N = 10,253, 2019–2020) was used. Based on a nurse turnover model, individual, health‐related, social work environment and work organizational factors were considered explainable variables for nurse turnover. Kaplan–Meier survival analysis and multivariate Cox regression analysis were used to identify the factors influencing female nurse turnover in South Korea.ResultsFemale nurses who had less education, were unmarried, were pregnant, and had higher stress levels and an increased probability of experiencing turnover as they aged. Those who perceived moderate health rather than good/very good health, had depressive symptoms, had a higher salary, were charge nurses/unit managers/supervisors or advanced practice nurses, were advanced practice nurses rather than registered nurses, worked shifts, worked in special care units or outpatient wards/administration as opposed to general wards, and worked in larger hospitals had a decreased probability of experiencing turnover as they aged. A two‐way interaction analysis revealed that those who had depressive symptoms and increased perceived stress were more likely to experience turnover as they aged.ConclusionMultiple factors influenced female nurse turnover, including individual, health‐related, social work environment and work organizational factors. A multidimensional approach is needed to reduce nurse turnover.ImpactVarious factors predict nurse turnover as nurses age, implying that a multifaceted approach is needed to manage nurse turnover. The influence of depressive symptoms on turnover should be evaluated by considering the perceived stress level. Nursing managers and policy makers could use our results to develop programs/policies to reduce nurse turnover.
They’re (not) playing our song: (Ir)religious identity moderates the effects of listening to religious music on memory, self‐esteem, and mood
Authors: Ysseldyk Renate , Karamally Talib , Kelly Ashleigh , Morton Thomas A. , Haslam S. Alexander 
Published: June 2021

AbstractPrevious research suggests that listening to music can enhance memory and well‐being. However, what is often missing from this analysis is consideration of the social dimensions of music—for example, its capacity to affirm or threaten listeners’ social identities. This study examined whether (ir)religious music that was potentially identity‐affirming or identity‐threatening (Christian hymns, Buddhist chants, classical, or no music) would affect Christians’ and Atheists’ (N = 267) well‐being and memory performance while listening. Analyses revealed significant interactions between (ir)religious group and music type on memory, self‐esteem, and mood. Listening to music that potentially threatened one's religious identity appeared to undermine both performance self‐esteem and actual memory performance, while increasing feelings of hostility. This pattern was found for Christians (vs. Atheists) who listened to Buddhist chants. Conversely, Atheists’ performance self‐esteem (and to some degree their memory performance) was lowest, and their hostility highest, when they listened to Christian hymns. In this way, listening to music that potentially threatened one's religious group identity (or lack thereof) appeared to be detrimental for memory, self‐esteem, and mood. These results bridge research on the psychology of religion, music psychology, and social identity theorizing by demonstrating that the effects of music on memory and well‐being may reflect important (even sacred) social identities, with potential implications for individual well‐being and intergroup relations.
Evaluation of peer bullying, internet addiction, and psychological adaptation level of students aged 9–15
Authors: Kelleci Meral , Tel Havva , Akgül Gündoğdu Nurcan , Temel Mert Zeynep 
Published: June 2021

AbstractPurposeThis study was conducted to evaluate peer bullying, internet addiction, and psychological adaptation capabilities of students in the 9–15 age group.Design and MethodsThe study was performed as cross‐sectional‐descriptive research with 880 students included in the research sample.FindingsOne‐fourth of the students in the 9–15 age group suffered from psychological adaptation issues, one‐fifth suffered from bullying issues, and 16.5% suffered from internet addiction.ConclusionThere is a need for early determination in risky age groups, a collaboration between parents and teachers in schools, and extended social studies on the prevention of peer bullying and internet addiction.
miR‐126‐3p is essential for CXCL12‐induced angiogenesis
Authors: Bassand Kévin , Metzinger Laurent , Naïm Meriem , Mouhoubi Nesrine , Haddad Oualid , Assoun Vincent , Zaïdi Naïma , Sainte‐Catherine Odile , Butt Amena , Guyot Erwan , Oudar Olivier , Laguillier‐Morizot Christelle , Sutton Angela , Charnaux Nathalie , Metzinger‐Le Meuth Valérie , Hlawaty Hanna 
Published: June 2021

AbstractAtherosclerosis, in the ultimate stage of cardiovascular diseases, causes an obstruction of vessels leading to ischemia and finally to necrosis. To restore vascularization and tissue regeneration, stimulation of angiogenesis is necessary. Chemokines and microRNAs (miR) were studied as pro‐angiogenic agents. We analysed the miR‐126/CXCL12 axis and compared impacts of both miR‐126‐3p and miR‐126‐5p strands effects in CXCL12‐induced angiogenesis. Indeed, the two strands of miR‐126 were previously shown to be active but were never compared together in the same experimental conditions regarding their differential functions in angiogenesis. In this study, we analysed the 2D‐angiogenesis and the migration assays in HUVEC in vitro and in rat's aortic rings ex vivo, both transfected with premiR‐126‐3p/‐5p or antimiR‐126‐3p/‐5p strands and stimulated with CXCL12. First, we showed that CXCL12 had pro‐angiogenic effects in vitro and ex vivo associated with overexpression of miR‐126‐3p in HUVEC and rat's aortas. Second, we showed that 2D‐angiogenesis and migration induced by CXCL12 was abolished in vitro and ex vivo after miR‐126‐3p inhibition. Finally, we observed that SPRED‐1 (one of miR‐126‐3p targets) was inhibited after CXCL12 treatment in HUVEC leading to improvement of CXCL12 pro‐angiogenic potential in vitro. Our results proved for the first time: 1‐the role of CXCL12 in modulation of miR‐126 expression; 2‐the involvement of miR‐126 in CXCL12 pro‐angiogenic effects; 3‐the involvement of SPRED‐1 in angiogenesis induced by miR‐126/CXCL12 axis.