bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Acupuncture On Cognitive Function In Poststroke Depression: Study Protocol For A Randomized, Placebo-Controlled Trial
Authors: Chen Ling , Chen Yi , Wu Lihua , Fu Wen , Wu Luanmian , Fu Wenbin 
Published: June 2021

Abstract
Introduction: Poststroke depression (PSD) is the most common mental complication after stroke and has a serious impact on functional outcomes and quality of life. Antidepressants are the first-line treatment for PSD, but many reported side effects remain. Clinical research has shown that acupuncture has a positive effect on PSD. This trial aims to study the efficacy and safety of acupuncture for PSD and to explore its effect on cognitive function. It is hypothesized that acupuncture treatment improves depressive symptom, cognitive behavior and negative emotion processing bias in PSD.Methods: In this randomized, placebo-controlled, single-blinded trial, fifty-six people with PSD will be randomly allocated into the intervention (n=28) or control (n=28) groups. The intervention group will receive acupuncture treatment, and the control group will receive sham acupuncture treatment, in 20 sessions over 4 weeks. The primary outcome is the change from baseline in the Hamilton Depression Scale-17 (HAMD-17) scores at week 4. Secondary outcomes include the Wisconsin Card Sorting Test (WCST) and latency and amplitude of P1, N170 and P3 of the event-related potentials (ERPs) components to assess the changes in cognitive function and electroencephalography. Outcomes are assessed at baseline and post intervention.Discussion: Acupuncture therapy could become an alternative treatment for PSD, and it is expected that this trial will provide reliable clinical evidence for the future use of acupuncture for the treatment of PSD.Trial registration: Chinese Clinical Trial Registry: ChiCTR1900026948. Registered on 27 October 2019.
Internet of things-based home noninvasive positive pressure ventilation in COPD patients with hypercapnic chronic respiratory failure: study protocol for a multicenter randomized controlled trial
Authors: Jiang Weipeng , Song Yuanlin 
Published: June 2021

Abstract
BackgroundHome noninvasive positive pressure ventilation (NIPPV) have become evidence-based care for stable hypercapnic chronic obstructive pulmonary disease (COPD) patients. There are still other challenges including appropriate follow-up, telemonitor and management to ensure treatment effectiveness, compliance and security, and to improve quality of life. The Internet of Things (IOT) is the name given to the network of devices and other “things” with built-in sensors, software, electronics and network connectivity, communicating these objects over wireless networks and sending data to a cloud platform. The study aims to evaluate the effectiveness and safety of the IOT-based management of NIPPV for the COPD patients with hypercapnic chronic respiratory failure.MethodsThis multicenter, prospective, randomized controlled trial will be conducted with a total of 200 COPD patients with chronic hypercapnic respiratory failure. Using a computer-generated randomization process, patients will be randomized (in a 1:1 ratio) into usual NIPPV (control group) or to receive additional IOT-based management (intervention group) for 12 months. The primary outcome is Severe Respiratory Insufficiency (SRI) questionnaire. Secondary outcomes include compliance with the ventilator, gas exchange, lung function, Health-related Quality of Life, hospitalization frequency, time to death within 1-year, all-cause mortality, safety analysis and cost-effectiveness analysis.DiscussionThis study will be the first and largest randomized trial in China to evaluate the effectiveness and safety of the IOT-based management of NIPPV for COPD patients with chronic hypercapnic respiratory failure. The results will help to understand the current situation of IOT based home ventilation and may provide new evidence for home NIPPV treatment and management in the future.Trial registrationChinese Clinical Trials Registry ChiCTR1800019536. Registered 17 November, 2018.
Comparative studies on adsorptive and photocatalytic potential of differently synthesized ferric oxide nanoparticles for malachite green
Authors: Kaur Kakanpreet , Kaur Manpreet , Ubhi Manpreet Kaur , Kaur Pervinder 
Published: June 2021

Abstract
In the present work, effect of different fuels on the structural, morphological, magnetic, adsorptive and photocatalytic properties of ferric oxide nanoparticles (Fe2O3 NPs) was evaluated. Fe2O3 NPs were synthesized via combustion method by using oxalyl dihydrazide (ODH), polyethylene glycol (PEG) and urea as fuels. The indigenously synthesized NPs were characterized by different analytical tools. XRD patterns confirmed the presence of α- and γ-Fe2O3 phases. TEM micrographs displayed average particle size was less than 30 nm. Saturation magnetization amplified with increase in the γ-Fe2O3 content, which was correlated to the fuel used for synthesis. Adsorptive and photocatalytic activity of synthesized NPs was studied using malachite green (MG) dye as a model compound. The uptake behavior for MG dye was influenced by the solution pH, contact time, adsorbent dose, temperature and dye concentration. Thermodynamic studies indicated the endothermic nature of the adsorption phenomenon. The adsorption was well defined with Langmuir and Freundlich isotherms in comparison to Dubinin-Radushkevitch adsorption isotherm model. The trend for percentage removal of MG dye using NPs synthesized by different fuels was: urea &gt; PEG &gt; ODH. Fe2O3 NPs facilitated photo degradation of dye solution in ultra-violet and visible light irradiations.
CHINA'S ROAD TO DIGITAL LEADERSHIP
Authors: Kuznetsova G. V. 
Published: June 2021

The article discusses the characteristics of China's advance to the position of the world digital leadership. The objectives of the study are the identifying of the most dynamically developing areas of digital transformation based on the integration of modern technologies, big data, artificial intelligence (AI), robotics, 3D printing, cloud technologies into supply chains for implementation in production processes. The impact of digitalization processes on the formation of a new society based on both traditional cultural values and high susceptibility to Western innovations is analyzed. There is a reversal of China's global strategy from a development model based on external factors to a wider use of internal regional reserves, which, in particular, is facilitated by the confrontation with the United States and the effect of the COVID-19 pandemic. It is concluded that achieving digital leadership in the competition with the United States for China is hardly possible in the foreseeable future. There are still insurmountable barriers on the way: the lack of economic freedoms, including in the field of using the Internet, environmental challenges that require structural restructuring of the economy, the presence of regional and social imbalances, a decline in economic growth, uncertainty in relations with the United States.
JOSEPH BIDEN’S NEW ECONOMIC POLICY: GLOBAL DIMENSION
Authors: Lebedeva L. F. , Aksenov P. A. 
Published: June 2021

The Biden’s administration took office when the US’s facing the global challenge of pandemic and the recession. Changes in American policy, particularly as concerning international trade, immigration; climate policy initiatives, represent new effects and challenges. Rejoining the Paris climate agreement was one of the first decisions of the new administration. The climate agenda means keeping global warming under control; and trade policy may be part of this process. Making economic development more inclusive and decarbonized, introducing new fuel efficiency standards needs time; as CO2 emissions per capita in US and Canada now are much higher than in France, Great Britain, Germany. Although president Biden entered office having majority in both chambers of Congress, it may not be enough for passing legislation concerning some aspects of his policy agenda, including climate, budget, immigration. So the President started to realize his policy immediately after inauguration through executive orders. Addressing the trade issues, environment agenda, the new administration underlines that approach to international economic relations will be different (from Trump’s priorities), restoring American leadership abroad. Being at the pathway toward recovery at the beginning of the current year, the American economy still needs support and stimulus under struggling with pandemic consequences.
IDENTIFICATION PRIORITY AREAS OF TRADE FACILITATION TO PROMOTE THE DEVELOPMENT OF RUSSIA'S FOREIGN TRADE
Authors: Nenadyshina Tatiana S. 
Published: June 2021

Currently global economic characterized such trends as increased geopolitical tensions and the expansion of the protectionist measures in the regulation of trade by the world biggest economies. An additional factor that seriously slowed down the global economy growth was the COVID-19 pandemic. These crisis effects provide opportunities for re-engineering the structure of global value chains and development Russian foreign trade. Based on the statistical data contained in the ratings and reports periodically published by the World Bank, the Organization for Economic Cooperation and Development, the International Institute for Management Development, the author identified the main problem areas that impede the conduct of foreign economic activity in Russia as well as barriers of the cross-border movement of goods. The integrated trade facilitation index for Russia was calculated having regard of above mentioned problem areas and barriers. The index characterizes the state of identified problem areas and barriers in relation to 121 countries. The main directions of trade facilitation to stimulate foreign trade and the integration of Russian manufacturers into the global value chains are proposed based on the factor analysis carried out on the basis of the integrated trade facilitation index variables.
A Didactic Escape Game for Emergency Medicine Aimed at Learning to Work as a Team and Making Diagnoses: Methodology for Game Development
Authors: Abensur Vuillaume Laure , Laudren Garry , Bosio Alexandre , Thévenot Pauline , Pelaccia Thierry , Chauvin Anthony 
Published: June 2021

Background
In the health care environment, teamwork is paramount, especially when referring to patient safety. We are interested in recent and innovative solutions such as escape games, which is a type of adventure game that may be highly useful as an educational tool, potentially combining good communication skills with successful gamification. They involve teams of 5 to 10 individuals who are “locked” in the same room and must collaborate to solve puzzles while under pressure from a timer.

Objective
The purpose of this paper was to describe the steps involved in creating and implementing an educational escape game. This tool can then be put into service or further developed by trainers who wish to use it for learning interprofessional collaboration. Therefore, we started with an experience of creating an educational escape game for emergency medicine teams.

Methods
We chose to develop an educational escape game by using 6 successive steps. First, we built a team. Second, we chose the pedagogical objectives. Third, we gamified (switched from objectives to scenario). Next, we found the human and material resources needed. Thereafter, we designed briefing and debriefing. Lastly, we tested the game.

Results
By following these 6 steps, we created the first ambulant educational escape game that teaches people, or nurses, doctors, and paramedics, working in emergency medicine to work as a team.

Conclusions
From a pedagogic point of view, this game may be a good tool for helping people in multidisciplinary fields (medical and paramedical teams) to learn how to work collaboratively and to communicate as a group. Above all, it seems to be an innovative tool that complements medical simulation–based learning and thus consolidates traditional education.
INVESTIGATION OF IN VITRO ANTIOXIDANT ACTIVITY AND CYTOTOXICITY ON HUMAN SKIN FIBROBLASTS OF PLUCHEA INDICA (L.) LESS. LEAVES EXTRACT AND DEVELOPMENT TO MICROEMULSION FOR SKIN COSMETIC PRODUCT
Authors: K ITSARASOOK , P PROMPAMORN , J TANGHIRANRAT , T PANICHAKUL 
Published: June 2021

Objectives: The aim of this study was to determine the antioxidant activity and cytotoxicity on normal human skin fibroblasts of Pluchea indica (L.) Less. leaves extract and to prepare the extract into microemulsions for application in skin cosmetic ingredient.
Methods: The total phenolics and total flavonoids content in ethanolic (30%, 70%, and 95% ethanol) and aqueous extracts of P. indica leaves were determined by Folin-Ciocalteu assay and aluminum chloride method. The quantification of 4,5-O-dicaffeoylquinic acid in the extracts was determined by an ultra-high performance liquid chromatography method. The antioxidant activity of extracts was examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), and ferric reducing antioxidant power (FRAP) assays. The cytotoxicity on human fibroblast cell was tested by sulforhodamine B assay. The oil in water microemulsion was prepared by pseudoternary phase diagram. The characterization of prepared-microemulsion including morphology, particle size, and polydispersity index (PDI) was studied and the physicochemical stability of microemulsions was evaluated.
Results: All P. indica leaves extracts contain a phenolic, flavonoid, and 4,5-O-dicaffeoylquinic acid contents. The 70% ethanolic extract possessed higher the antioxidant activities than 30% ethanolic, aqueous, and 95% ethanolic extracts, respectively, followed by DPPH, ABTS, and FRAP assay. Thus, the 70% ethanolic extract was selected to develop in skin cosmetic. The 70% ethanolic extract had not cytotoxicity on dermal human skin fibroblasts cell. The microemulsion loaded extract provided a mean particle size of 24.397±1.20 nm with minimum PDI of 0.397±0.05 which shown a spherical shape. The microemulsion loaded extract showed a good stability.
Conclusion: From all results, it has concluded that the 70% ethanolic extract of P. indica leaves contain phenolic, flavonoid, and 4,5-O-dicaffeoylquinic acid contents which possessed DPPH, ABTS+, and FRAP activities. In addition, this extract had no cytotoxic to normal human skin fibroblasts. Finally, the microemulsion loaded extract showed a good characterization and physicochemical stability.
ACUTE AND SUBACUTE TOXICITY STUDIES OF ETHANOLIC EXTRACT OF MIRABILIS JALAPA LINN IN WISTAR ALBINO RATS
Authors: C SENTHIL KUMARI , KESAVELU DHANASEKHAR 
Published: June 2021

Objective: The objective of the study was to evaluate the toxicological potential of the ethanolic extract of leaves of Mirabilis jalapa linn through acute and subacute toxicity studies in albino Wistar rats.
Methods: For acute toxicity studies, the ethanolic extract of M. jalapa was given up to 2000 mg/kg and then the animals were observed for 14 days to find out any adverse effect or death. For sub-acute toxicity studies, the exact was given for 28 days and the following parameters were observed such as changes in body weight, food intake, water intake, hematological parameters, biochemical parameters, lipid profile, urine analysis, and histopathological studies were undertaken.
Results: Single oral administration of 2000 mg/kg of the ethanolic extract of M. jalapa produced no mortality or signs of toxicity. During subacute toxicity there were no changes in body weight, food intake and water intake were observed. There were no changes in lipid profile, hematological parameters, and biochemical parameters. In histopathological changes, there were no structural changes in treated groups when compared to control.
Conclusion: The leaves of ethanolic extract of M. jalapa is safe when administered for 28 days.
There were no deaths or signs of toxicity in treated rats during acute toxicity studies and subacute toxicity studies.
EVALUATION OF IN VITRO ANTICANCER ACTIVITY OF AERIAL PARTS OF AVICENNIA ALBA PLANT METHANOLIC EXTRACT AGAINST HELA AND MCF-7 CELL LINES
Authors: MICHAEL RA ZERUBABEL 
Published: June 2021

Objective: The current study emphasizes the effects of stem and leaf methanolic extract of mangrove plant Avicennia alba on human tumor cell lines HeLa and MCF-7.
Method: The collected mangrove plant sample was subjected to extraction with methanol and screened for anticancer activity according to 3-(4,5-dimethythiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method. The ability of the plant extract to inhibit the proliferation of HeLa and MCF-7 cell lines procured from NCCS Pune was compared parallel to inhibitory effect of standard drug Cisplatin. The spectrophotometric optical densities obtained were plotted on graph and consecutive data were obtained to depict the inhibitory effect and IC50 values. The histopathology studies were also done for a clear insight to understand the depth of inhibition microscopically.
Results: The MTT assay performed illustrates the plant samples with different concentrations (10, 20, 25, 30, and 50 μg) showed significant inhibitory effect on comparison with the standard drug Cisplatin. The IC50 values and the inhibitory OD values elucidate effective projection of plant as a potential source of anticancer activity based on comparative study. The histopathology studies revealed an insight to a clearer picture of how the cells growth was controlled. It was found that the methanolic extract of A. alba exhibited more activity against HeLa cell lines than MCF-7 cell lines.
Conclusion: The synergistic effect of various phytochemicals present in the methanolic plant extract played a significant role in establishing the plant as a significant anticancer source.
COMPARATIVE STUDY OF INCIDENCE RATES AND ANTIBIOGRAM OF CATHETER-ASSOCIATED URINARY TRACT INFECTIONS IN INTENSIVE CARE UNIT VERSUS NON-INTENSIVE CARE UNIT AT A TERTIARY CARE TEACHING HOSPITAL
Authors: JOB MICAH , MONACHAN MOBISHA , SCARIA RESMI , BABU MERLIN 
Published: June 2021

Objective: Catheter-associated urinary tract infections (CAUTI) is the most common HAI which leads to increased hospital stay and morbidity. The study aimed to compare the incidence rates of CAUTI per 1000 catheter days and their antimicrobial susceptibility pattern between intensive care unit (ICU) and non ICU and to determine predisposing risk factors, indications, and outcomes of CAUTI.
Methods: A comparative observational study was conducted in ICU and non ICU for a period of 6 months. The sample size of the study was 120. The data were collected, analyzed in terms of both inferential and descriptive statistics.
Results: The incidence rate per thousand catheter days in non ICU was more as compared to ICU. The significant risk factors associated with CAUTI were the duration of catheterization and type 2 diabetes mellitus. The majority of the patients were catheterized for indications such as critically ill and unconsciousness followed by measurement of urine output. The outcomes of CAUTI were increased duration of hospitalization and recovery of patients. All the Gram-positive and Gram-negative isolates from non ICU were sensitive to piperacillin + tazobactam and meropenem. All the isolates from ICU and non ICU were resistant to co-trimoxazole.
Conclusion: The urinary catheter is an essential part of modern medical care. Unfortunately, when used inappropriately or when left in place for too long, it is a hazard to the patient. This study helps to prevent indiscriminate and irrational use of antibiotics which contribute to emerging of drug resistance strains.
IN VITRO AND IN VIVO ANTIFUNGAL ACTIVITY OF ALKALOID 3,5-bis(4,4’’-dimethoxy- [1,1’:2’,1’’-terphenyl]-4’-yl)-4H-pyrazole-4,4-diol FROM DERRIS INDICA (LAM) BENNETT SEEDS
Authors: TABASSUM NUZHAT , G. M. VIDYASAGAR , D RAGHUNANDAN , I SHIVAKUMAR 
Published: June 2021

Objectives: The aim of the present study is to isolate an antifungal compound from Derris indica (Lam) Bennett seed oil with various solvents and evaluation of its antifungal activity against the clinical species of Candida.
Methods: D. indica seed hexane extract was tested against Trichophyton rubrum, Trichophyton tonsurans and Candida albicans. Hexane extract was fractioned using different solvents through column chromatography (CC). Isolated compound D1 was identified and characterized using ultraviolet, Fourier-transform infrared, 1HNMR, and mass spectroscopy. In vitro evaluation of D1 carried out against 12 Candida strains. In vivo evaluation of D1 carried out against T. rubrum, T. tonsurans, and C. albicans using an excision wound healing model on male Wistar rats.
Results: Different concentrations of hexane extract showed antimicrobial activity against tested microorganism with varying minimum inhibitory concentration values. On fractionation with hexane-petroleum ether through CC, it yielded a crystalline fraction. Compound D1 characterized as a 3,5-bis (4,4’’-dimethoxy-[1,1’: 2’,1’’-terphenyl]-4’-yl)-4H-pyrazole-4,4-diol. A novel alkaloid compound from D. indica is a new report and proved to be inhibitory against C. albicans MTCC 3017 (14.83±0.28), MTCC 1637 (16.0±0.0), Candida glabrata MTCC 3814 (16.83±0.28) and MTCC 3014 (16.66±0.57), Candida tropicalis MTCC 230 (20.0±0.0), MTCC 1406 (12.33±0.57). C. glabrata MTCC 3981 was found to be resistant to the compound. In vivo studies showed no visual symptoms at the end of treatment indicating the therapeutic property of the compound.
Conclusion: The D1 was found to be effective against human fungal pathogens and can be used as a base molecule in designing new antifungal drugs.
COMPARISON OF PROGRESSION OF SPONTANEOUS VERSUS INDUCED LABOR IN PRIMI AND MULTIPAROUS WOMEN
Authors: MADAN ANITA , SHARMA SUJATA , YEDLA YASHASVINI , KAUR JAGDEEP 
Published: June 2021

Objectives: The objectives of the study were to compare progression of spontaneous versus induced labor in primigravida and multigravida women.
Methods: Pregnant women admitted in Labor room of Bebe Nanaki mother and Child Care Centre, Amritsar during April 2019–March 2020 were selected for this study. A total of 200 pregnant women were selected and divided into two groups. Women in group A were induced while in group B were women with spontaneous onset of labor. Labor progression in both was compared.
Results: In group A, the mean duration of the active phase in primigravida was 4.08±2.30 h and in multigravida was 4.02±2.20 h. In group B, the mean duration of active phase in primigravidas was 7.24±1.39 h and in multigravidas was 6.48±1.40 h. In group A, the mean duration of the second stage in a primigravida was 25.5±8.15 min and in a multigravida was 17.38±9.95 min. In group B, the mean duration of the second stage in a primigravida was 41.3±9.6 min, while in a multigravida was 22.72±6.2 h.
Discussion: The mean duration of active phase in group A in the primigravida and multigravida was almost similar, showing that induction does not have any effect on the duration of active phase. The mean duration of the second stage of group A in primigravida was 25 min and multipara was 17 min showing that induction reduces the duration of the second stage.
Conclusion: Induction of labor when done at the right gestational age for correct indication is beneficial to women as it reduces the complications caused due to the continuation of high-risk pregnancies.