bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional content overrides spatial attention
Authors: Bekhtereva Valeria , Craddock Matt , Müller Matthias M. 
Published: May 2021

AbstractSpatial attention is our capacity to attend to or ignore particular regions of our spatial environment. However, some classes of stimuli may be able to override our efforts to ignore them. Here we assessed the relationship between involuntary attentional capture with emotional images and spatial attention at early stages of perceptual processing. Multiple scenes of unpleasant and neutral content were displayed in rapid serial visual presentation (RSVP) streams that elicited the steady‐state visual evoked potential (SSVEP), a neural marker of selective attention at early visual areas. In a spatial cueing task, participants were cued to covertly attend to RSVP streams presented at 4 and 6 Hz presentation rates in the left and right visual hemifields. The task was to detect square targets occasionally displayed within the image streams, responding only to those appearing on the cued side. The RSVP streams were always neutral pictures in one visual hemifield but would unpredictably switch from neutral to aversive content in the other visual hemifield. We found that SSVEP amplitude was consistently modulated by a change in emotional valence of image streams, regardless of whether the change in content occurred in the attended or unattended spatial location, reflecting an automatic sensory amplification for affective stimuli. The present data provide further evidence in support that emotional images can attract visual processing resources independently of spatial attention allocation, and are consistent with sustained sensory facilitation of early visual areas through re‐entrant feedback projections from higher‐order cortical areas involved in the extraction of affective information.
Longitudinal Strength, Power, and Push-Start Performance Changes in a Skeleton Athlete: Case Study
Authors: Mosey Tim J. , Mitchell Lachlan J.G. 
Published: May 2021

Objectives: The purpose of this study was to document the longitudinal strength and power characteristic changes and race performance changes of a skeleton athlete. Method: Longitudinal strength and power changes were assessed with strength and power diagnostic testing over a 9-year period. Trends over 9 years for relative strength were analyzed using a linear model. Push-start time was recorded across multiple tracks. Trends over 9 years for start performance at each track were assessed using a mixed-effects linear model to account for the impact of different tracks. Lower-body strength and power changes were assessed via a 1-repetition-maximum squat and a body-weight countermovement jump. The relationship between strength and power changes was assessed over time. The relationship between strength changes and start performance was determined by assessing the fixed effect of relative strength changes on push-start time. Results: Relative lower-body strength ranged from 1.6 kg per body weight to 1.9 kg per body weight and showed a significant mean improvement of 0.05 kg per body weight per year (R2 = .71, P < .01). A negative correlation (R2 = .79) between relative strength changes and push-start performance across multiple tracks was found. The mixed-effects model indicated that push-start time improved significantly year to year (0.02 s; P < .001; R2 = .74) when controlling for the effect of track. Conclusions: The longitudinal analysis of push-start time and the associations with changes in strength suggest that training this quality can have a positive effect on push-start performance.
Physical Fitness of Rural Polish School Youth: Trends Between 1986 and 2016
Authors: Bartkowiak Sylwia , Konarski Jan M. , Strzelczyk Ryszard , Janowski Jarosław , Karpowicz Małgorzata , Malina Robert M. 
Published: May 2021

Background: The objective of the study was to evaluate secular changes in the physical fitness of rural school youth, 7–15 years, in west-central Poland between 1986 and 2016.Methods: The fitness of cross-sectional samples of school youth resident in the same 10 communities was evaluated in 4 decennial surveys: 1986—1417 boys/1326 girls; 1996—979 boys/947 girls; 2006—871 boys/843 girls; and 2016—1189 boys/1105 girls. Five tests evaluated speed (5-m run), agility (figure 8 run), explosive power (vertical jump), flexibility (stand and reach), and cardiovascular fitness (modified Harvard step test). Age- and sex-specific descriptive statistics were calculated by survey, while differences among surveys were compared in 3 broad age groups (7–9, 10–12, and 13–15 y) using analysis of variance with age and age squared as covariates.Results: Speed and flexibility declined, while the jump and step test index changed variably across surveys. Although agility improved across surveys, the major improvement occurred between 1986 and 1996.Conclusions: Performances of rural school youth on 5 tests of physical fitness changed significantly, but, variably, between 1986 and 2016. The results were generally consistent with other studies of Polish school youth that spanned a similar interval.
Implementing pharmaceutical track-and-trace systems: a realist review
Authors: Kootstra Joeke , Kleinhout-Vliek Tineke 
Published: May 2021

IntroductionOne way to prevent falsified medical products from entering the regulated pharmaceutical supply chain is to implement a pharmaceutical track-and-trace system (PTTS). Such systems in the most extensive versions generally mandate a scan at every point of contact with the medical product: from the point of entry to dispensation. There have been several attempts to implement such systems; for example, a ‘full’ PTTS in Turkey and the more pared-down version offered by the European Union’s Falsified Medicines Directive and Delegated Act. This study aims to identify facilitators and barriers to implementing (elements of) a PTTS, with the Turkish system used as a benchmark.MethodsWe conducted a ‘realist’ review, which synthesises literature and aims to establish how a specific technology works, for whom, under which circumstances. We searched Embase, Medline Ovid, Web of Science, Cochrane Central and Google Scholar databases, yielding 2,790 scholarly articles. We selected 21 for review.ResultsImplementation of PTTS elements has been attempted in different compositions in several primarily high-income and middle-income countries. Factors that affected implementation included stakeholders like the government and supply chain actors, the coordination between them, and their awareness, knowledge, and skills, as well as regulation and legislation, monetary investments, and technical and digital requirements.ConclusionThe interplay between contextual factors is crucial for successful PTTS implementation. Specifically, the findings indicate that aligning the incentives for all actors and allowing for adjustments in a continuous implementation process will likely facilitate implementation.
Unmet need for primary healthcare and associated individual and household-level factors in Kenya: results from a national survey
Authors: Otieno Peter O , Kiroro Francis , Runyenje Cynthia , Kamau Pauline 
Published: May 2021

ObjectiveTo determine the prevalence of unmet need for primary healthcare and associated individual and household-level factors in Kenya.DesignThe data for this study are drawn from the 2016 Kenya Integrated Household Budget Survey (KIHBS). A multistage sampling technique involving a systematic selection of clusters at the national level and final selection of households was used.SettingThis study was conducted in Kenya. The KIHBS is a nationally representative survey on a wide range of indicators to assess the progress made in improving the living standards of the population at the national level.ParticipantsA total of 9447 households comprising 15 539 household members who reported a sickness or injury over the 4 weeks preceding this survey were included in this study. The study respondents comprised of the household heads.Primary outcome measureThe primary outcome of this study is unmet need for primary healthcare defined as an unexpressed demand for primary healthcare following a reported sickness or injury over the 4 weeks preceding this survey.ResultsAbout one in every five study participants experienced an unexpressed demand for primary care. The odds of having unmet need for primary healthcare were 68% higher among participants without health insurance coverage compared with those with health insurance (adjusted OR 1.68; p<0.001; 95% CI 1.34 to 2.09) and 45% higher among households headed by single or unmarried persons compared with the those who were in a marital union (adjusted OR 1.45; p<0.05; 95% CI 1.06 to 1.98).ConclusionsOur findings show that there is still a considerable unexpressed demand for primary care services despite widespread implementation of Universal Health Coverage (UHC) in Kenya, with households without a health insurance cover bearing the highest burden. Therefore, the design of UHC reforms in Kenya should focus on embedding social health protection to escalate the demand for primary healthcare services.
Association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19 including clinical course, morbidity and mortality outcomes? A systematic review
Authors: Grove Amy , Osokogu Osemeke , Al-Khudairy Lena , Mehrabian Amin , Zanganeh Mandana , Brown Anna , Court Rachel , Taylor-Phillips Sian , Uthman Olalekan A , McCarthy Noel , Kumar Sudhesh , Clarke Aileen 
Published: May 2021

ObjectiveTo systemically review and critically appraise published studies of the association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19, including clinical course, morbidity and mortality outcomes.DesignSystematic review.Data sourcesMEDLINE (OVID), Embase (OVID), Cochrane Central Register of Controlled Trials, MedRxiv and BioRxiv preprint databases. COVID-19 databases of the WHO, Cochrane, CEBM Oxford and Bern University up to 10 June 2020.Study selectionStudies that assessed vitamin D supplementation and/or low serum vitamin D in patients acutely ill with, or at risk of, severe betacoronavirus infection (SARS-CoV, MERS-CoV, SARS-CoV-2).Data extractionTwo authors independently extracted data using a predefined data extraction form and assessed risk of bias using the Downs and Black Quality Assessment Checklist.ResultsSearches elicited 449 papers, 59 studies were eligible full-text assessment and 4 met the eligibility criteria of this review. The four studies were narratively synthesised and included (1) a cross-sectional study (n=107) suggesting an inverse association between serum vitamin D and SARS-CoV-2; (2) a retrospective cohort study (348 598 participants, 449 cases) in which univariable analysis showed that vitamin D protects against COVID-19; (3) an ecological country level study demonstrating a negative correlation between vitamin D and COVID-19 case numbers and mortality; and (4) a case–control survey (n=1486) showing cases with confirmed/probable COVID-19 reported lower vitamin D supplementation. All studies were at high/unclear risk of bias.ConclusionThere is no robust evidence of a negative association between vitamin D and COVID-19. No relevant randomised controlled trials were identified and there is no robust peer-reviewed published evidence of association between vitamin D levels and severity of symptoms or mortality due to COVID-19. Guideline producers should acknowledge that benefits of vitamin D supplementation in COVID-19 are as yet unproven despite increasing interest.
Association between early bronchiolitis and the development of childhood asthma: a meta-analysis
Authors: Wang Guizuo , Han Dong , Jiang Zhengdong , Li Manxiang , Yang Shumei , Liu Lu 
Published: May 2021

ObjectiveEarly life bronchiolitis has been hypothesised to be associated with the subsequent risk of persistent wheezing or asthma. However, the link remains controversial. The objective of our study was to evaluate the association between bronchiolitis before 2 years of age and the late-onset wheezing/asthma.DesignSystematic review and meta-analysis.MethodsPubMed, Embase and Web of Science databases were systematically searched for studies published between 1955 and January 2020. Meanwhile, we also checked through the reference lists of relevant articles to see whether these references included reports of other studies that might be eligible for the review. Cohort and case–control studies assessing the association between early-life bronchiolitis and late-onset wheezing/asthma were included in this meta-analysis. Data were extracted by two independent reviewers. Results were pooled using a random-effects model or fixed-effects model according to the heterogeneity among studies.Results32 original articles with 292 844 participants, which met the criteria, were included in this meta-analysis. Bronchiolitis before 2 years of age was associated with an increased risk of subsequent wheezing/asthma (relative risk=2.46, 95% CI 2.14 to 2.82, p<0.001). After categorising studies into different groups based on age at the end of follow-up, geographical region and study quality, the association still remained significant.ConclusionsThe meta-analysis indicates an association between bronchiolitis before 2 years of age and the wheezing/asthma in later life. Well-designed and highly standardised prospective studies that better address bias due to potential confounding factors are needed to validate the risk identified in our meta-analysis.PROSPERO registration numberCRD42018089453.
Identifying factors associated with overweight and obesity among intermediate school students aged 12–15 years in school settings: mixed-methodology protocol
Authors: Almutairi Naif Saleh , Burns Sharyn , Portsmouth Linda 
Published: May 2021

IntroductionChildhood obesity is a public health concern globally. In Arab countries, the prevalence of overweight and obesity has increased significantly over the last three decades. The level of childhood overweight and obesity in the Kingdom of Saudi Arabia (KSA) is high and continues to increase. This study will explore factors associated with overweight and obesity among adolescents and identify barriers and enablers to the implementation of comprehensive school-based obesity prevention interventions.Methods and analysisSocioecological model will inform this mixed-methods study. The study will include three phases: (1) a scoping review of the literature; (2) the development of a student survey instrument and (3) a mixed-method study comprising a cross-sectional survey targeting students aged 12–15 years with the collection of the students’ height and weight measurements; one-on-one interviews with physical education teachers and school principals; and the administration of school climate audits using the Health Promoting School framework. Reliability and validity of the survey instrument will be examined during survey development. Descriptive, inferential and thematic analysis will be employed using appropriate statistical software.Ethics and disseminationEthical approval has been granted from the Curtin University of Human Research Ethics Committee (HR2020-0337) and from the KSA Ministry of Education (4181827686). School principals will provide permission to conduct the study in individual schools. Individual consent/assent will be obtained from students and their parents, and teachers. Study findings will be disseminated via peer-review publications, reports and conferences.
COVID-19 prevention practices in urban setting during early introduction of the disease: results from community survey in SNNP Region, Ethiopia
Authors: Endriyas Misganu , Kawza Aknaw , Alano Abraham , Hussen Mamush , Shibru Endashaw 
Published: May 2021

ObjectiveTo assess community practices related to COVID-19 prevention and its associated factors during the early introduction of the disease to the study area.Setting and participantsA community-based cross-sectional study was conducted in Southern Nations, Nationalities and People’s Region, Ethiopia. Ten zonal towns with high population density and mobility and 1239 participants were included in the study.Outcome measureA semistructured questionnaire was uploaded to SurveyCTO data collection system with security patterns. Mask usage was assessed by observation, while social distancing and handwashing were assessed by interview. Data were collected by health professionals who have Bachelor of Science degree and above and analysed using SPSS V.25. Descriptive statistics and binary logistic regression were performed.ResultsFrom 1239 individuals, about half, 657 (53%), of respondents were women and about two-thirds, 795 (64.2%), were married. Nearly 9 out of 10 (90.3%) and about 8 out of 10 (82.0%) respondents reported that they frequently wash hands with soap and/or use sanitiser and keep social distancing as means to prevent COVID-19, respectively. Less than three-fifths (57.8%) of respondents wore masks during the interview. In summary, about half (48.9%) of respondents were practising the three recommended methods (social distancing, handwashing and wearing masks). Sex, educational status, family size and overall knowledge about COVID-19 were associated with practising COVID-19 prevention measures.ConclusionCOVID-19 prevention practice was low as only about half of participants were practising social distancing, handwashing and wearing masks. Although awareness creation has been implemented through different forms of media, it should be strengthened in different local languages. Concerned government bodies should strictly follow using masks in public gatherings.
Use of the ReSVinet Scale for parents and healthcare workers in a paediatric emergency service: a prospective study
Authors: Camacho-Cruz Jhon , Briñez Shirley , Alvarez Jorge , Leal Victoria , Villamizar Gómez Licet , Vasquez-Hoyos Pablo 
Published: May 2021

IntroductionMost scales for acute respiratory infection (ARI) are limited to healthcare worker (HCW) use for clinical decision-making. The Respiratory Syncytial Virus network (ReSVinet) Scale offers a version for parents that could potentially help as an early warning system.ObjectiveTo determine whether or not the ReSVinet Scale for ARI in infants can be reliably used by HCWs and parents in an emergency service.MethodsA prospective study was done of infants with ARI who were admitted to a paediatric emergency room to assess the ReSVinet Scale when used by faculty (paediatric doctor-professors), residents (doctors doing their first specialty in paediatrics) and parents. Spearman’s correlation and a weighted kappa coefficient were used to measure interobserver agreement. Internal consistency was also tested by Cronbach’s alpha test.ResultsOverall, 188 patients, 58% male, were enrolled. A Spearman’s correlation of 0.92 for faculty and resident scoring and 0.64 for faculty or resident and parent scoring was found. The weighted kappa coefficients were 0.78 for faculty versus residents, 0.41 for faculty versus parents, and 0.41 for residents versus parents. Cronbach’s alpha test was 0.67 for faculty, 0.62 for residents and 0.69 for parents.ConclusionThere was good correlation in the ReSVinet scores between health professionals when used in the paediatric emergency area. Agreement between parents and health professionals was found to be more variable. Future studies should focus on finding ways to improve its reliability when used by parents before the scale is used in the emergency room.
Dengue virus infection induces inflammation and oxidative stress on the heart
Authors: Kangussu Lucas Miranda , Costa Vivian Vasconcelos , Olivon Vania Claudia , Queiroz-Junior Celso Martins , Gondim Antônio Nei Santana , Melo Marcos Barrouin , Reis Daniela , Nóbrega Natália , Araújo Natália , Rachid Milene Alvarenga , Souza Renan Pedra de , Tirapelli Carlos Renato , Santos Robson Augusto Souza dos , Cruz Jader dos Santos , Teixeira Mauro Martins , Souza Danielle da Glória de , Bonaventura Daniella 
Published: May 2021

ObjectiveDengue fever is one of the most important arboviral diseases in the world, and its severe forms are characterised by a broad spectrum of systemic and cardiovascular hallmarks. However, much remains to be elucidated regarding the pathogenesis triggered by Dengue virus (DENV) in the heart. Herein, we evaluated the cardiac outcomes unleashed by DENV infection and the possible mechanisms associated with these effects.MethodsA model of an adapted DENV-3 strain was used to infect male BALB/c mice to assess haemodynamic measurements and the functional, electrophysiological, inflammatory and oxidative parameters in the heart.ResultsDENV-3 infection resulted in increased systemic inflammation and vascular permeability with consequent reduction of systolic blood pressure and increase in heart rate. These changes were accompanied by a decrease in the cardiac output and stroke volume, with a reduction trend in the left ventricular end-systolic and end-diastolic diameters and volumes. Also, there was a reduction trend in the calcium current density in the ventricular cardiomyocytes of DENV-3 infected mice. Indeed, DENV-3 infection led to leucocyte infiltration and production of inflammatory mediators in the heart, causing pericarditis and myocarditis. Moreover, increased reactive oxygen species generation and lipoperoxidation were also verified in the cardiac tissue of DENV-3 infected mice.ConclusionsDENV-3 infection induced a marked cardiac dysfunction, which may be associated with inflammation, oxidative stress and electrophysiological changes in the heart. These findings provide new cardiac insights into the mechanisms involved in the pathogenesis triggered by DENV, contributing to the research of new therapeutic targets for clinical practice.