bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Multidimensional Assessment for Pediatric Patients in Radiotherapy (M.A.P.-RT) Tool for Customized Treatment Preparation: RADAR Project
Authors: Chiesa Silvia , Marconi Elisa , Dinapoli Nicola , Sanfilippo Maria Zoe , Ruggiero Antonio , Mastronuzzi Angela , Panza Giulia , Serra Annalisa , Massaccesi Mariangela , Cacchione Antonella , Beghella Bartoli Francesco , Chieffo Daniela Pia Rosaria , Gambacorta Maria Antonietta , Valentini Vincenzo , Balducci Mario 
Published: March 2021

Aims: Pediatric patients may experience considerable distress during radiotherapy. Combining psychological interventions with standard therapies can reduce the need for sedation. The RADAR Project aims to use a systematic method of recording data that can reveal patients' difficulties and fragility during treatment.In this context, the aim of our study was to investigate the ability of a multidimensional assessment tool (M.A.P.-RT schedule) to predict the need for sedation during radiotherapy. The schedule, which is administered during the first evaluation, was created to collect information on patients and their families in a standardized way.Materials and Methods: The study enrolled pediatric patients (aged 0–18 years or 18–21 with cognitive impairment). Data were collected by means of the M.A.P.-RT module; this explores various thematic areas, and is completed by the radiation oncologist, psychologist and nurse during their first evaluation. Features were selected by means of the Boruta method (random forest classifier), and the totals of the significant partial scores on each subsection of the module were inserted into a logistic model in order to test for their correlation with the use of anesthesia and with the frequency of psychological support. The results of logistic regression (LR) were used to identify the best predictors. The AUC was used to identify the best threshold for the scores in the evaluation.Results: A total of 99 patients were considered for this analysis. The feature that best predicted both the need for anesthesia and the frequency of psychological support was the total score (TS), the AUC of the ROC being 0.9875 for anesthesia and 0.8866 for psychological support.Conclusion: During the first evaluation, the M.A.P.-RT form can predict the need for anesthesia in pediatric patients, and is a potential tool for personalizing therapeutic and management procedures.
KRAS Mutational Regression Is Associated With Oligo-Metastatic Status and Good Prognosis in Metastatic Colorectal Cancer
Authors: Ottaiano Alessandro , Nasti Guglielmo , Santorsola Mariachiara , Altieri Vincenzo , Di Fruscio Giuseppina , Circelli Luisa , Luce Amalia , Cossu Alessia Maria , Scognamiglio Giosuè , Perri Francesco , Correra Marco , Belli Andrea , Delrio Paolo , Botti Gerardo , Caraglia Michele 
Published: March 2021

BackgroundWe previously reported that loss of KRAS mutations (“regressive” mutational trajectories) from primary tumors to metastases associated with the oligo-metastatic status in colorectal cancer (CRC). The present study was undertaken in order to analyze the mutational trajectories of KRAS in a well-characterized cohort of CRC patients who developed poly- or oligo-metastatic disease.Material and MethodsPatients were treated and followed-up according to European Society of Medical Oncology guidelines. Primary CRC FFPE tissue and metastatic circulating-free DNA were extracted using the QIAamp DNA specific kits (Qiagen, Hilden, Germany). Samples were sequenced with the Oncomine Solid Tumour DNA kit (Thermo Fisher Scientific, Waltham, MA, USA). Plasma collection for liquid biopsy was done from 1 to 14 days before starting first-line chemotherapy. Analysis of the prognostic power of KRAS evolutionary trajectories was done with uni- and multivariate analyses.ResultsOne-hundred-fourteen patients were enrolled. Sixty-three patients presented with mutated KRAS (mutKRAS) and 51 with wild-type KRAS (wtKRAS). KRAS mutational concordance was high (70.1%).Two divergent subsets were identified: mutKRAS in primary tumors and wtKRAS in metastatic ones (regressive: mutKRAS → wtKRAS in 8.8% of patients), and vice versa (progressive: wtKRAS → mutKRAS in 21.1% of patients). An association between KRAS regressive trajectory and the oligo-metastatic status (P &lt;0.0001) was found. At multivariate analysis, regressive and progressive mutational trajectories emerged as independent prognostic factors for survival, with Hazard Ratios of 0.22 (CI 95%: 0.08–0.61; median survival: not reached) and 2.70 (CI 95%: 1.11–6.56, median survival: 12.1 months), respectively.ConclusionsOur data provide evidence that the evolutionary trajectories of KRAS can have a strong clinical prognostic role and that they can be involved in discriminating between poly-metastatic aggressive vs oligo-metastatic indolent CRC.
Photodynamic Therapy Using Cerenkov and Radioluminescence Light
Authors: Spinelli Antonello E. , Boschi Federico 
Published: March 2021

In this short review the potential use of Cerenkov radiation and radioluminescence as internal sources for Photodynamic therapy (PDT) is discussed. PDT has been developed over the course of more than 100 years and is based on the induced photo conversion of a drug called photosensitizer (PS) that triggers the production of cytotoxic reactive oxygen species (ROS) leading to the killing of the cells. In order to overcome the problem of light penetration in the tissues, different solutions were proposed in the past. The use of radioisotopes like: 18F, 64Cu, 90Y, 177Lu as internal light sources increase the light fluence at the PS compared to an external source, resulting in a larger cytotoxic effect.
Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells
Authors: Chen Yating , Huang Yun , Bai Jing , Liu Chuanbin , Ma Shanshan , Li Jiaxin , Lu Xu , Fu Zihao , Fang Lihua , Li Yang , Zhang Jiancheng 
Published: March 2021

AimThe aim was to study the effect of Allitridum (Allicin) on the heterologous expression of the late sodium current on the ΔKPQ-SCN5A mutations in HEK293 cells, with a view to screening new drugs for the treatment of long QT syndrome type 3 (LQT3).Methods and ResultsThe ΔKPQ-SCN5A plasmid was transiently transferred into HEK293 cells by liposome technology and administered by extracellular perfusion, and the sodium current was recorded by whole-cell patch-clamp technology. Application of Allicin 30 μM reduced the late sodium current (INa,L) of the Nav1.5 channel current encoded by ΔKPQ-SCN5A from 1.92 ± 0.12 to 0.65 ± 0.03 pA/pF (P &lt; 0.01, n = 15), which resulted in the decrease of INa,L/INa,P (from 0.94% ± 0.04% to 0.32% ± 0.02%). Furthermore, treatment with Allicin could move the steady-state inactivation of the channel to a more negative direction, resulting in an increase in channel inactivation at the same voltage, which reduced the increase in the window current and further increased the inactivation of the channel intermediate state. However, it had no effect on channel steady-state activation (SSA), inactivation mechanics, and recovery dynamics after inactivation. What’s more, the Nav1.5 channel protein levels of membrane in the ΔKPQ-SCN5A mutation were enhanced from 0.49% ± 0.04% to 0.76% ± 0.02% with the effect of 30 mM Allicin, close to 0.89% ± 0.02% of the WT.ConclusionAllicin reduced the late sodium current of ΔKPQ-SCN5A, whose mechanism may be related to the increase of channel steady-state inactivation (SSI) and intermediate-state inactivation (ISI) by the drug, thus reducing the window current.
A Highly Compact Antipodal Vivaldi Antenna Array for 5G Millimeter Wave Applications
Authors: Dixit Amruta Sarvajeet , Kumar Sumit , Urooj Shabana , Malibari Areej 
Published: March 2021

This paper presents a compact 1 × 4 antipodal Vivaldi antenna (AVA) array for 5G millimeter-wave applications. The designed antenna operates over 24.19 GHz–29.15 GHz and 30.28 GHz–40.47 GHz frequency ranges. The proposed antenna provides a high gain of 8 dBi to 13.2 dBi and the highest gain is obtained at 40.3 GHz. The proposed antenna operates on frequency range-2 (FR2) and covers n257, n258, n260, and n261 frequency bands of 5G communication. The corrugations and RT/Duroid 5880 substrate are used to reduce the antenna size to 24 mm × 28.8 mm × 0.254 mm, which makes the antenna highly compact. Furthermore, the corrugations play an important role in the front-to-back ratio improvement, which further enhances the gain of the antenna. The corporate feeding is optimized meticulously to obtain an enhanced bandwidth and narrow beamwidth. The radiation pattern does not vary over the desired operating frequency range. In addition, the experimental results of the fabricated antenna coincide with the simulated results. The presented antenna design shows a substantial improvement in size, gain, and bandwidth when compared to what has been reported for an AVA with nearly the same size, which makes the proposed antenna one of the best candidates for application in devices that operate in the millimeter frequency range.
Prospects of using less common autochthonous grape varieties for production of wines in Armenia
Authors: Самвелян Гаруш Александрович , Самвелян Агнесса Гарушевна , Манукян Арман Эмилевич , Симонян Нуне Рубеновна , Аветисян Гор Маркосович , Остроухова Елена Викторовна 
Published: March 2021

Возросший интерес к винам из стран, считающихся родиной виноделия (Армения, Грузия, Греция, Румыния), связан со своеобразием ароматов и вкусов, обусловленных местными традиционными сортами винограда. Однако сортовой состав автохтонного винограда, используемый в производстве вин в Армении, весьма ограничен. Нами поставлена цель выявить и изучить перспективность малораспространенных, забытых аборигенных армянских сортов винограда для производства высококачественных вин. Актуальность работы связана с увеличением сырьевых ресурсов виноградовинодельческой отрасли республики. Для исследования были выбраны аборигенные красные сорта Тозот, Кохбени, Арени (контроль) из двух регионов Армении. Опытные виноматериалы были приготовлены в условиях микровиноделия. Двухлетние изучения технохимических показателей и органолептическая оценка опытных образцов выявили перспективность использования красных (Тозот и Кохбени) сортов автохтонного винограда в качестве сырья для производства вин высокого качества в разных регионах Армении.
Recent years the increased interest in wines from countries considered to be the birthplace of winemaking (Armenia, Georgia, Greece, Romania) is associated with the uniqueness of aroma and flavor of the local traditional grape varieties. However, the variety assortment of autochthonous grapes used in wine production in Armenia is very limited. Our goal is to find out and study the prospects of less common autochthonous Armenian grape varieties for the high quality wine production. The relevance of this work is associated with the increase in the amount of raw materials of the viticultural and winemaking industry of the Republic. Red autochthonous grape varieties 'Tozot', 'Koghbeni', 'Areni' (as the control) from two regions of Armenia were selected for the research. Experimental base wines were produced in the conditions of microvinification. A two-year research of technochemical indicators and organoleptic assessment of experimental samples revealed the potential of using local red varieties ('Tozot' and 'Koghbeni') as raw materials for the high quality wine production in different regions of Armenia. The research was carried out with the financial support of State Science Committee of the Ministry of Education and Science of the Republic of Armenia within the framework of scientific project No. 18T-2K024.
Further on the History of the Veneration of the wonder-working icon of Nicholas of Zaraysk
Authors: Мазуров А.Б. 
Published: March 2021

В статье рассмотрены иконографические особенности иконы «Никола Зарайский в житии», являвшейся в XVII – начале XX вв. храмовым образом и главной святыней Никольского собора г. Зарайска. Икона, являющаяся списком с древнего утраченного византийского («корсунского») оригинала XIII века, ранее датировалась 1513 г. Предлагается отнести памятник к 1528-1531 гг. и связать его появление с моментом завершения строительства наиболее раннего каменного Никольского храма XVI в., являвшегося духовным центром строившегося в это же время Зарайского кремля. Образ является ценным источником для реконструкции особенностей его прототипа. Доказывается, что древний корсунский образ не имел житийных клейм. Чтимая в народе икона породила значительное количество копий и повторений. Выявлено более 40 иконографических источников XIII - первой трети XVI вв. (живописные иконы, деревянные и каменные резные иконы и иконки, произведения шитья, крест-мощевик), которые восходят к древнему оригиналу (наиболее яркая черта которого, помимо иконографии Николы Зарайского, – крестчатая фелонь), повторяя его во многих деталях. Вместе с тем, акцентирована и возможность вариаций в трактовке деталей. Проанализированный массив источников позволяет утверждать, что прототип списка 1528–1531 г. в том виде, в каком мы его знаем сейчас, существовал уже не позднее конца XIII века.
The article studies the iconographic details of the icon «Nicolas of Zaraysk in His Life» which was the principal image and the main shrine of St. Nicholas Cathedral in Zaraysk between the 17th and the early 20th centuries. Copied from the Byzantine (Korsun) icon from the 13th century, the icon has been traditionally dated 1513. The author suggests that the icon's origin should be dated 1528–1531 and associated with the end of the construction of the earliest stone St. Nicholas Church of the 16th century. It was the religious center of the Zaraysk Kremlin which was also under construction at the time. The image is a critical source for recreating the details of its prototype. The author brings evidence that the Korsun image had no hagiographic border scenes. The popular icon has been copied numerous times. Over 40 iconographic sources from between the 13th and the first third of the 16th centuries have been identified (pictorial icons, wood, and stone carved icons and miniatures, sewing works, a reliquary cross) that go back to the medieval original (the cross phelonion being the most striking feature, apart from the iconography of Nicholas of Zaraysk) and copy its many details. Besides that, the possibility of variable details has been emphasized. Based on the analyzed sources, the author suggests that the prototype of the copy from 1528–1531, as we know it today, had already existed in the late 13th century or earlier.
Optimal phase shift mask and multilayer stack with the evaluation of imaging performance and process latitude in extreme ultraviolet high numerical aperture
Authors: Kang In-Hwa , Park Jang-Gun , Ban Chung-Hyun , Oh Hye-Keun 
Published: March 2021

Abstract
In high numerical aperture (NA) extreme ultraviolet lithography, which is used to implement a finer linewidth of 10 nm or lower, serious problems arise in patterning as the NA increases. To alleviate such problems, a thin absorber and a multilayer with good reflective efficiency and improved pattern quality are required. To develop an effective EUV photomask for the commercialization of high-NA systems, we determined the optimal ruthenium (Ru)/silicon (Si) multilayer structure using a phase-shift mask (PSM) absorber. A Ru/Si multilayer

d

R
u

=
2.2

nm
,

d

S
i

=
4.7

nm

using PSM as an absorber has a smaller best-focus range and placement error compared to the molybdenum (Mo)/silicon (Si) multilayer. At the same time, it provides improved image contrast, enabling more stable patterning. Even when the number of layers of the Ru/Si multilayer was reduced, it was confirmed that the reflectance efficiency and image quality were maintained.
Fabrication of nano-capillary emitter arrays for ionic liquid electrospray thrusters
Authors: Suzuki Kanta , Nagao Masayoshi , Liu Yongxun , Murakami Katsuhisa , Khumpuang Sommawan , Hara Shiro , Takao Yoshinori 
Published: March 2021

Abstract
In this study, we fabricated nano-capillary emitter arrays for stable ion emission of ionic liquid electrospray thrusters, employing the fabrication of field emitter arrays or gated nano electron sources. A nano-capillary emitter was successfully fabricated with a 100–300 nm capillary diameter, which prevented ionic liquid leakage by significantly increasing the fluidic impedance of the ionic liquid compared to a previously proposed emitter. An ion emission experiment was conducted with 1-ethyl-3-methylimidazolium dicyanamide as the propellant. Ion emission started at a low voltage of 61 V owing to a small gap of approximately 1 μm between the emitter and extractor electrode. The maximum current density was 43 mA cm−2 on the positive side and −13 mA cm−2 on the negative side without leakage of the ionic liquid, which was more than 100 times higher than that of conventional electrospray thrusters. Moreover, we obtained continuous ion emission without current intercepted by the extractor.
Effectiveness Of Stepping Dose Ozonated Virgin Coconut Oil For Wound Healing In Autologous Full Thickness Skin Graft In Terms Of Fibroblast Proliferation And The Expression Of Vascular Endothelial Growth Factor In Sprague Dawley Rats
Authors: Napitupulu Johan Rinto Even , Hardian Hardian , Najatullah Najatullah 
Published: March 2021

Abstract
Background: Now, Skin grafts are one of the therapies of choice in the wound healing process. And this is still developing today. The process of formation fibroblas and the formation of vascular endothelial growth factor have an important role in healing skin graft wounds. Ozonated virgin coconut oil has an important role in wound healing.
Objective: To prove the effect of ozonated virgin coconut oil in various doses in increasing number of fibroblas and expression of vascular endothelial growth factor of skin graft wounds.
Methods: This study is an experimental study with "Randomized parallel study with controlled group design" on 40 Sprague Dawley rats which are performed an autologous skin graft at the same time. Samples were divided randomly into 8 groups (K1 and K2 = without ozonated VCO), (A1 and A2 = ozonated VCO 50,4 mg/ml), (B1 and B2 = ozonated VCO 103,2 mg/ml), (C1 and C2 = ozonated VCO 204 mg/ml). Evaluation of the amount of fibroblas was done by staining hematoxylin & eosin after the 6th day and the expression of vascular endothelial growth factor was done by staining immunohistochemistry after the 12th day after skin graft.
Results: Statistical analysis of the amount of fibroblas after the 6th day was found to be significantly different between the K1 vs A1 group (p = 0.029), K1 vs B1 (p = 0.004), K1 vs C1 (p = 0.000), on the 12th day was found significantly different the amount of fibroblast between K2 vs A2 ( p = 0,029 ), K2 vs B2 ( p = 0,010 ), K2 vs C2 ( p = 0,001 ). The expression of vascular endothelial growth factor on the 6th day was found a significant difference between the K1 vs A1 group (p = 0.024), K1 vs B1 (p = 0.005), K1 vs C1 (p = 0.001), on the 12th day was found significantly different the expression of vascular endothelial growth factor between K2 vs A2 ( p = 0,011 ), K2 vs B2 ( p = 0,036 ), K2 vs C2 ( p = 0,004 ) .
Conclusion: Ozonated VCO can increase the amount of fibroblas and expression of vascular endothelial growth factor in the wound healing process of autologous skin graft in Sprague Dawley rats.
Keywords: Ozonated VCO, full thickness skin graft, fibroblas, VEGF.
Pengaruh Latihan Zumba Terhadap Resting Heart Rate dan Peak Expiratory Flow Rate Pada Wanita Usia Dewasa Muda
Authors: Ruberto Sandro , Supatmo Yuswo , Setiawati Erna , Ambarwati Endang 
Published: March 2021

Latar Belakang: Kurangnya aktivitas fisik merupakan salah satu faktor risiko terjadinya mortalitas, sehingga sangat penting untuk melakukan aktivitas fisik secara rutin. Zumba adalah salah satu metode aktivitas fisik yang banyak diminati dan memiliki manfaat terutama untuk kesehatan kardiorespirasi.
Tujuan: Mengetahui pengaruh latihan Zumba terhadap Resting Heart Rate (RHR) dan Peak Expiratory Flow Rate (PEFR) sebagai indikator kesehatan sistem kardiorespirasi.
Metode: Penelitian ini merupakan penelitian eksperimental menggunakan pre-test and post-test control group design. Terdapat 26 subjek penelitian yang dibagi ke dalam 2 kelompok yaitu kelompok perlakuan dan kontrol. Latihan Zumba dilakukan selama 60 menit dengan frekuensi 2 kali seminggu selama 8 minggu secara virtual. Pengukuran RHR dilakukan secara mandiri oleh subjek penelitian pada pagi hari saat bangun tidur dan pengukuran PEFR dilakukan dengan menggunakan peak flow meter.
Hasil: Setelah dilakukan latihan Zumba selama 8 minggu didapatkan penurunan RHR pada kelompok perlakuan dari 71 ± 9 denyut/menit menjadi 70 ± 8 denyut/menit namun tidak signifikan (p>0,05). Pada kelompok perlakuan juga mengalami peningkatan PEFR yang signifikan dari 364 ± 36 liter/menit menjadi 397 ± 42 liter/menit (p<0,05). Namun, hasil RHR dan PEFR kelompok perlakuan tidak berbeda bermakna dengan kelompok kontrol.
Simpulan: Latihan Zumba dapat meningkatkan PEFR dan menurunkan RHR. Namun, peningkatan PEFR dan penurunan RHR ini tidak berbeda signifikan dengan kelompok yang tidak mendapatkan latihan Zumba. Hal ini bisa disebabkan karena faktor ketepatan gerak yang dilakukan masih kurang karena tidak adanya supervisi gerakan yang dilakukan subjek penelitian oleh instruktur Zumba.
Kata Kunci : peak expiratory flow rate ; resting heart rate ; zumba
Growing Dimorphandra wilsonii in different substrates and levels of shading
Authors: Queiroz M. M. , Frigo G. B. , Dias L. C. , Castro R. V. O. 
Published: March 2021

Dimorphandra wilsonii Rizzini is a tree species endemic to transition area between the “Cerrado” and the Atlantic Forest in the central region of the State of Minas Gerais, Brazil. The aim of this study was to evaluate the influence of different substrate compositions and levels of shading on the growth of Dimorphandra wilsonii. Seedlings were grown in different substrates: subsoil from Paraopeba; subsoil; commercial substrate BIOPLANT®; cattle manure; soil from Paraopeba and cattle manure (1:1); subsoil and cattle manure (1:1); commercial substrate and cattle manure (1:1); as well as in different levels of shading, as follows: abundant sunlight; half shading (Sombrite® 50%); and full shading (Sombrite® 80%). This study used a completely randomized experimental design. Producing D. wilsonii seedlings using a substrate comprised of 50% cattle manure and 50% subsoil in a shaded greenhouse proved to be effective
Hasil belajar model discovery learning dalam peningkatan partisipasi belajar pembelajaran PPKn kelas X SMAN 1 Lemahabang
Authors: Suhimo  , Firmansyah Yudi , Susanto Erwin 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui hasil belajar dalam peningkatan partisipasi belajar model discovery learning dalam pembelajaran Pendidikan Pancasila dan Kewarganegaraan siswa kelas X SMAN 1 Lemahabang. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriftif. Subjek dalam penelitian ini ialah guru PPKn, siswa Kelas X, wakasek kurikulum, teknik pengumpulan data dalam penelitian ini terdiri dari observasi, wawancara, dokumentasi. teknik analisis data dalam penelitian ini adalah triangulaasi. Hasil penelitian menunjukan bahwa hasil belajar ketika menerapkan model discovery learning Pendidikan Pancasila dan Kewarganegaraan partisipasi belajar siswa meningkat, siswa juga lebih aktif pada saat pembelajaran berlangsung, siswa juga terbiasa untuk menyampaikan pendapatnya sendiri. Rekomendasi penelitian ini, bagi sekolah selaku pemangku kebijakan diharapkan untuk mendukung guru ketika menerapkan model discovery learning untuk mendapatkan hasil belajar yang maksimal, bagi guru diharapkan untuk selalu menerapkan model discovery learning secara maksimal untuk mencapai hasil belajar yang diharapkan, bagi siswa diharapkan ketika guru menerapkan model discovery learning dalam pembelajar siswa menjadi lebih aktif pada saat pembelajaran berlangsung.