bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards Enhanced Catalytic Activity of Magnetic Nanoparticles Integrated into 3D Reduced Graphene Oxide for Heterogeneous Fenton Organic Dye Degradation
Authors: Sadegh Fatemeh , Politakos Nikolaos , Sanz Oihane , Modarresi-Alam Ali Reza , Tomovska Radmila 
Published: April 2021

Abstract
Composite Fenton nanocatalyst was prepared by water-based in situ creation of Fe3O4 nanoparticles integrated within self-assembly 3D reduced graphene oxide (rGO) aerogel. It was used for degradation of Acid Green 25 (AG-25) organic dye in aqueous solution, in presence of H2O2. By investigating the conditions that maximize the dye adsorption by the 3D composite, it was found that the pH of the solution should be adjusted between the pKa of the functional groups presented on the rGO surface (carboxylic acid) and that of the dye (sulfonic acid) to promote electrostatic interactions dye − 3D structure. Performed under these conditions, Fenton degradation of AG-25 in presence of H2O2 was completed in less than 30 min, including all the intermediate products, as demonstrated by MALDI-TOF-MS analysis of the aqueous solution after discoloration. Moreover, this was achieved in a solution with as high dye concentration as 0.5 mg/mL, with only 10 mg of 3D composite catalyst, at room temperature and without additional energy input. The high performance was attributed to the creation of charge transfer complex between the rGO and Fe3O4 nanoparticles throughout covalent bond C-O-Fe, the formation of which was promoted by the in situ synthesis procedure.
A Bibliometric Analysis of the Cannabis and Cannabinoid Research Literature
Authors: Ng Jeremy Y. 
Published: April 2021

Abstract
Background: Cannabis refers to a flowering plant in the family Cannabaceae, which has been used medically, recreationally, and industrially. The history of cannabis has been both long and complex, however, the last few decades have seen a large increase in the volume of literature on this topic. The objective of the present bibliometric analysis is to capture the characteristics of peer-reviewed publications on the topic of cannabis and cannabinoid research.Methods: Searches were run on April 02, 2021, and results were exported on the same day to prevent discrepancies between daily database updates. Only “article” and “review” publication types were included; no further search limits were applied. The following bibliometric data were collected: number of publications (in total and per year), authors and journals; open access status; journals publishing the highest volume of literature and their impact factors; language, countries, institutional affiliations, and funding sponsors of publications; most productive authors; and most highly-cited publications. Trends associated with this subset of publications were identified and presented. Bibliometric networks were constructed and visualized using the software tool VOSviewer.Results: A total of 29 802 publications (10 214 open access), published by 65 109 authors were published in 5474 journals from 1829 to 2021. The greatest number of publications were published over the last 20 years. The journal that published the largest number of publications was Drug and Alcohol Dependence (n=705). The most productive countries included the United States (n= 12 420), the United Kingdom (n=2236), and Canada (n=2062); many of the most common intuitional affiliations and funding sponsors also originated from these three countries.Conclusions: The number of publications collectively published on the topic of cannabis follows an upward trend. Over the past 20 years, the volume of cannabis research has grown steeply, which can be largely attributed to the existence of a large amount of funding dedicated to research this topic. Future research should continue to investigate changes in the publication characteristics of emerging cannabis research, especially as it is expected that the body of publications on this topic is expected to rapidly grow.
Fabrication and Characterization of an Antibacterial Chitosan/Silk Fibroin Electrospun Nanofiber Loaded with a Cationic Peptide for Wound-dressing Application
Authors: Khosravimelal Sadjad , Chizari Milad , Farhadihosseinabadi Behrouz , Moghaddam Mehrdad Moosazadeh , Gholipourmalekabadi Mazaher 
Published: April 2021

Abstract
Wound infections are still problematic in many cases and demand new alternatives for current treatment strategies. In recent years, biomaterials-based wound dressings have received much attention due to their potentials and many studies have been performed based on them. Accordingly, in this study, we fabricated and optimized an antibacterial chitosan/silk fibroin (CS/SF) electrospun nanofiber bilayer containing different concentrations of a cationic antimicrobial peptide (AMP) for wound dressing applications. The fabricated CS/SF nanofiber was fully characterized and compared to the electrospun silk fibroin and electrospun chitosan alone in vitro. Then, the release rate of different concentrations of peptide (16, 32, and 64 µg/ml) from peptide-loaded CS/SF nanofiber was investigated. Finally, based on cytotoxic activity, the antibacterial activity of scaffolds containing 16 and 32 µg/ml of peptide was evaluated against standard and multi-drug resistant strains of Staphylococcus aureus and Escherichia coli isolated from burn patients. The peptide-loaded CS/SF nanofiber displayed appropriate mechanical properties, high water uptake, suitable biodegradation rate, a controlled release without cytotoxicity on Hu02 human foreskin fibroblast cells at the 16 and 32 µg/ml concentrations of peptide. The optimized CS/SF containing 32 µg/ml peptide showed strong antibacterial activity against all experimental strains from standard to resistant. The results showed that the fabricated antimicrobial nanofiber has the potential to be applied as a wound dressing for infected wound healing, although further studies are needed in vivo.
A Long contiguous stretches of homozygosity disclosed a novel biallelic pathogenic variant in STAG3 causing Primary Ovarian Insufficiency
Authors: Mellone Simona , Zavattaro Marco , Vurchio Denise , Ronzani Sara , Caputo Marina , Leone Ilaria , Prodam Flavia , Giordano Mara 
Published: April 2021

Abstract
Background: Primary ovarian insufficiency (POI) refers to an etiologically heterogeneous disorder characterized by hypergonadotropic hypogonadism that represents a major cause of infertility in women under 40 years. Most cases of isolated POI still appear sporadically, but ∼10–15% have an affected first-degree relative, indicating a significant genetic etiology. Several genes implicated in development, meiosis, hormonal signaling and metabolism are involved in the genetic form of the disorder in both syndromic and isolated POI. However, most cases of POI remain unsolved even after exhaustive investigation. Results: Here is reported a 19-year-old Senegalese female affected by non-syndromic POI showing primary amenorrhoea, who well answered to the hormonal induction of puberty reaching a complete sexual maturation in two years. In order to investigate the presence of a genetic defect, aCGH-SNP analysis was performed. A 13.5 Mb long contiguous stretch of homozygosity (LCSH) region on chromosome 7q21.13-q22.1 was identified where the exome sequencing revealed a novel homozygous 4-bp deletion (c.3381_3384delAGAA) in STAG3 . Pathogenic variants in this gene, encoding for a meiosis-specific protein, have been previously reported as cause POI in only seven families and recently as cause of infertility in a male. The here identified mutation leads to the truncation of the last 55 aminoacids, confirming the important role in meiosis of the STAG3 C-terminal domain. Conclusions: In conclusion we identified a loss of function variant in STAG3 in a Senegalese woman with POI reinforcing the role the cohesin complex in the genetic etiology of this disorder. This gene should be included in the screening of POI to offer a better genetic counseling and long term follow-up considering the risk of ovarian tumor in woman carrying pathogenic variants in genes involved in germ cell differentiation.
The Effect of the COVID-19 Pandemic on Health Care Workers’ Anxiety Levels: A Meta-Analysis (Preprint)
Authors: Zhang Lunbo , Yan Ming , Takashima Kaito , Guo Wenru , Yamada Yuki 
Published: April 2021

BACKGROUND

The COVID-19 pandemic has been declared a public health emergency of international concern; this has caused excessive anxiety among health care workers. In addition, publication bias and low-quality publications have become widespread, which can result in the dissemination of unreliable findings.

OBJECTIVE

This paper performed a meta-analysis with the following two aims: (1) to examine the prevalence of anxiety among health care workers and determine whether it has increased due to the COVID-19 pandemic, and (2) to investigate whether there has been an increase in publication bias.

METHODS

All related studies that were published/released from 2015 to 2020 were searched in electronic databases (Web of Science, PubMed, PsyArXiv, and medRxiv). The risk of bias in individual studies was assessed using the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) checklist. The heterogeneity of the studies was assessed using the I2 statistic. The effect size (prevalence rates of anxiety) and a 95% CI for each paper were also calculated. We used a moderator analysis to test for the effect of COVID-19 on health care workers’ anxiety levels and detect publication bias in COVID-19 studies. We also assessed publication bias using the funnel plot and Egger regression.

RESULTS

The pooled meta-analysis prevalence was 35.3% (95% CI: 32.2%−38.4%). The moderator analysis revealed no significant difference between articles related to COVID-19 and those unrelated to COVID-19 (p = 0.831). Moreover, no significant difference was found between articles related to COVID-19 and preprints (p = 0.981). Significant heterogeneity was found in each subgroup. Egger’s tests revealed publication bias in articles related to COVID-19 and preprints (p < 0.001).

CONCLUSIONS

Our study found no significant differences in the effect sizes (prevalence of anxiety) between studies related and those unrelated to COVID-19. Concluding whether the anxiety state of health care workers is altered by the COVID-19 pandemic currently is difficult. However, we have strong evidence that their anxiety levels are always high, although this could also be a false positive caused by a large publication bias. Moreover, without comparing the results with those of non-healthcare workers, we cannot be sure that their anxiety is particularly high. The present study highlights the need to generalize valid and reliable measurements to more accurately examine health care workers’ anxiety in the future. Furthermore, we found a large publication bias in studies; however, the quality of the studies is relatively stable and reliable.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/24136
The health-related quality of life of patients with a benign gynecological condition: a 2-year follow-up
Authors: Pynnä Kristiina , Räsänen Pirjo , Sintonen Harri , Roine Risto P , Vuorela Piia 
Published: April 2021

Aim:
To assess health-related quality of life (HRQoL) of patients with benign gynecological disorders.
Materials & methods:
Prospective 2-year follow-up with the 15D HRQoL-instrument of 311 women treated in Helsinki-area hospitals in 2012–2013.
Results:
The initially impaired HRQoL regarding excretion, discomfort and symptoms, and vitality and sexual activity improved after treatment. However, only sexual activity reached similar levels as in the general population. Treatment of endometriosis, fibroids and polyps resulted in best and that of unspecific pelvic pain and bleeding disorders in worst HRQoL scores. Results were independent of hospital size.
Conclusion:
The impaired HRQoL dimensions were improved by treatment but HRQoL still remained poorer than in the general female population. Treatment of unspecific pelvic pain and bleeding disorders needs further evaluation.
Faktor-Faktor Risiko Yang Berhubungan Dengan Hipertensi Di Wilayah Kerja Puskesmas Rawang Kota Sungai Penuh Tahun 2020
Authors: Kartika Mory , Subakir Subakir , Mirsiyanto Eko 
Published: April 2021

World Health Organization (WHO) tahun 2015 menunjukkan sekitar 1,13 miliar orang di dunia menyandang hipertensi. Jumlah penderita hipertensi yang terhitung pada bulan Februari – Maret sebanyak 122 orang, bulan Juni sebanyak 72 orang dan bulan Juli sebanyak 22 orang. Penelitian ini bertujuan untuk mengetahui faktor-faktor risiko yang berhubungan dengan hipertensi di wilayah kerja Puskesmas Rawang Kota Sungai Penuh Tahun 2020. Penelitian ini merupakan penelitian analitik dengan pendekatan case control. Penelitian ini bertempat di pemukiman wilayah kerja Puskesmas Rawang Kota Sungai Penuh yang dilakukan pada bulan September 2020. Populasi dalam penelitian ini kelompok kasus adalah seluruh pasien yang menderita hipertensi pada bulan Juni-Juli 2020 yang berjumlah 72 orang. Analisa data dalam penelitian ini secara univariat dan bivariat. Penelitian ini dilakukan dengan menggunakan lembar kuesioner. Hasil penelitian ini menunjukkan bahwa ada hubungan kegemukan dan merokok dengan kejadian hipertensi di wilayah kerja Puskesmas Rawang Kota Sungai Penuh Tahun 2020 dimana nilai p < 0,05. Tidak ada hubungan stres dengan kejadian hipertensi di wilayah kerja Puskesmas Rawang Kota Sungai Penuh Tahun 2020. Diharapkan hasil penelitian ini dapat meningkatkan pelayanan kesehatan kepada tenaga medis khususnya dalam melakukan identifikasi dan intervensi hipertensi dan faktor risikonya sehingga dapat meningkatkan kesehatan penderita hipertensi.
Kata Kunci: kegemukan, merokok, stres, hipertensi
Analisis belanja daerah menurut urusan dan hubungannya terhadap jumlah pengangguran di Provinsi Jambi
Authors: Naza Danal Al Ahlul , Rahmadi Selamet , Rosmeli Rosmeli 
Published: April 2021

This study aims to determine and analyze: 1). The dynamics of regional expenditure development according to functions, namely mandatory and optional functions as well as the number of unemployed people in Jambi Province during the period 2008 - 2018, 2). Allocation of regional expenditure to regional expenditure according to mandatory and optional functions in Jambi Province during the period 2008 - 2018 and 3). The relationship between regional expenditure according to mandatory functions and optional functions to the number of unemployed people in Jambi Province during the period 2008-2018. The data analysis method used in this study was the Pearson development, ratio, and correlation formulas. Based on the results of research during the years 2010-2018, the results are regional expenditure according to mandatory functions, regional expenditure according to selected functions, and the number of unemployed in Jambi Province has increased on average. The allocation of regional expenditures according to mandatory functions and regional expenditures according to selected functions in Jambi Province has increased on average. Expenditures according to mandatory functions and expenditures according to selected functions have a very strong and negative relationship to the number of unemployed in Jambi Province during 2010-2018 at α = 1% two-tailed (2-tailed) test.
Keywords: Obligatory affairs, regional spending according to selected functions, the number of unemployed
Long stent graft for frozen elephant trunk repair in acute type A aortic dissection
Authors: Wang Chaojie , Zhang Wenqian , Peng Jihai , He Jie , Xu Wenliu , Chen Guangtian , Fan Xiaoping 
Published: April 2021

OBJECTIVES: The frozen elephant trunk (FET) technique has become an
important tool in the treatment of acute type A aortic dissection. The
aim of this study was to evaluate the effect of long FET on spinal cord
injury (SCI) and distal aortic remodeling after acute type A aortic
dissection based on clinical and radiological outcomes. METHODS: From
January 2018 to November 2019, 158 patients [mean age 51.8 years
(range 32 - 78 years), 88.6% male] with acute type A aortic
dissection were treated by FET with 100 mm (n=113) or 150 mm (n=45) open
hybrid stent graft prosthesis. Patients were divided into two groups
according to the length of FET. The clinical and radiological outcomes
of the patients were reviewed retrospectively. RESULTS: Postoperative
outcomes did not differ significantly: in-hospital mortality (9.7% vs
6.7%, P=0.758) and SCI (5.3% vs 2.2%, P=0.674). Aortic remodeling,
which was evaluated by aortic diameter, true lumen diameter, false lumen
diameter and the rate of false lumen complete thrombosis, was more
positive in long FET group in the descending thoracic aorta during the
follow-up period. At the abdominal level, there was no statistically
significant difference between the two groups. CONCLUSIONS: The long
version of FET does not increase the risk of SCI in patients with acute
type A aortic dissection. The application of long FET can achieve better
results in terms of remodeling of the thoracic aorta in the short- and
medium-term follow-up.
PARÁSITOS METAZOARIOS Y OTROS EPIBIONTES EN EL OSTIÓN DEL PLACER CRASSOSTREA CORTEZIENSIS (HERTLEIN, 1951) EN DOS ZONAS COSTERAS DEL PACÍFICO MEXICANO
Authors: Tejeda-Arenas Denisse , Medina-Jasso Alejandra , Nieves-Soto Mario , Grano-Maldonado Mayra I. 
Published: April 2021

El objetivo de este estudio fue determinar la presencia de parásitos metazoarios y epibiontes en el ostión del placer Crassostrea corteziensis (Hertlein, 1951) en dos localidades costeras y pesqueras del estado de Sinaloa, en el noroeste del Pacífico mexicano. Se colectaron 30 ostiones en la cooperativa pesquera de “Playa norte” en la bahía de Mazatlán, Sinaloa y se realizó una comparación con la presencia de parásitos en ostiones en la laguna costera de “Ceuta”. La inspección de ostiones en la laguna costera reveló la presencia de 36 metacercarias encapsuladas de la familia Acanthocolpidae en la gónada del ostión C. corteziensis. En la bahía de Mazatlán, en la zona de Playa norte, se encontraron seis metacercarias: tres de la sp. 1 (pertenece a la familia Hemiuridae) en el manto, un espécimen de sp.2 (Familia Fellodistomidae) en la glándula digestiva y una metacercaria sp3. no identificada en el manto, una metacercaria de (Familia Zoogonidae) en la glándula digestiva, dos nemátodos de vida libre del género Theristus sp. Como organismos epibiontes se encontraron siete ejemplares de poliquetos de la familia Nereididae en la concha de los ostiones. Este trabajo reporta por primera vez la invasión del digeneo Stephanostomum sp. Looss, 1899 de la familia Acanthocolpidae parásito de la gónada del ostión C. corteziensis en el Pacífico mexicano. Así como, la presencia de digeneos pertenecientes a la familia Fellodistomidae, Hemiuridae y Zoogonidae. Los resultados de este trabajo contribuyen al conocimiento en la biología, la biodiversidad y la preferencia del hospedero de estos parásitos, con posibles implicaciones en los riesgos para la salud que plantea el consumo humano del ostión del placer, con gran regionalización en el consumo de mariscos crudos que presentan amplia identidad social gastronómica en estas zonas costeras en el Pacífico mexicano.
25. Snapping Turtle Conservation in Ontario
Authors: Wilson Rachel , Samuel Payal , Teather Molly , Usher Leslie , Windsor Jake 
Published: April 2021

Populations of snapping turtles are declining in Ontario. These reptiles play essential roles in wetland habitats through removal of dead animals and weeds, and their eggs provide food sources for mammals and birds. Despite being listed as a species of special concern under Ontario’s Endangered Species Act, hunting of snapping turtles is permitted in some regions of Ontario. Snapping turtles are further threatened by pollution, road mortality, and habitat loss. The developmental process of this species also acts as an obstacle to their recovery, as sexual maturity is not reached until the age of 16-19 and only 7 out of 10,000 eggs is expected to survive to adulthood. With the assistance of contacts at the Suzuki Foundation, Guelph University, and other institutions, we intend to develop a conservation strategy for snapping turtles that consists of four components. First, we recommend a government-mandated, province-wide survey of snapping turtle statistics to determine turtle populations and threats. Then we will address whether sustainable hunting is possible. The current catch allowance of two turtles per person daily, as deemed sustainable by the MNR, should be suspended until further review. Next, barriers to recovery will be addressed. Prevention of threats could be achieved through conservation area designations, signs indicating turtle presence, information on how to avoid causing turtle injury and distribution of information to persons whose property contains snapping turtle habitat. Finally, increasing public awareness of snapping turtle demographics is crucial to our strategy. Education through multiple channels will generate public interest and funding.
MEMBANTU NAGARI MEMBANGUN DI AUR KUNING KECAMATAN PASAMAN KABUPATEN PASAMAN BARAT
Authors: Nurmiati Nurmiati , Prastika Ossy Y. , Fadhlan M. Fiqri 
Published: April 2021

Nagari Aua Kuniang is one of the Nagari in Pasaman Subdistrict, West Pasaman Regency, having an area of 13,745 km2 consisting of 6 jorong, Jorong Padang Tujuh, Sukomananti, Pinaga, Lubuak Landua, Bukik Nilam and Lembah Binuang. The Income of the community depend on plantations such as Oil Palm and Cocoa and crops planting such as corn and with existing tourism potential such as mountain tourism, waterfalls and most importantly cultural tourism and religious tourism such as prohibited fish in the Surau Inyiak Lubuak Landua complex, then the development of the Aua Kuniang village is very likely to be developed. The low level of public education is one of the factors that can hinder the development of the nagari. To help nagari Aua Kuniang develop, counseling, training or pilot activities are conducted covering the fields of Nutrition and Health, the Environment, Education, Religion and Culture and the Law and Human Rights, which are carried out through the KKN-PPM program from Andalas University involving students from various study programs. During the program implementation, counseling, training or piloting have been carried out 12 programs in the field of Nutrition and Health, 9 programs in the field Environment, 11 programs in the field of Education, Religion and Culture and Law and 7 programs in the field of Human Rights.
Comparación de sustratos en la propagación sexual y asexual del árbol de la quina (Cinchona officinalis)
Authors: Vásquez Castañeda Julvio Horacio , Lápiz Sabaleta Epifanio , Barboza Hernández Marlitt K. Y. , Vásquez Meza Stefany Nicole , Quispe Sánchez Luz Maribel 
Published: April 2021

<p>En la investigación se comparó ocho tipos de sustratos en la propagación sexual y asexual de <em>C. officinalis</em> en proporciones de , (70 % de humus + 20 % de tierra orgánica + 10% de arena); (70 % de hojarasca +20 % de tierra orgánica +10 % de arena) ; (70 % franco arenoso + 20% de tierra orgánica +10 % de arena); (35% de humus + 35% de hojarasca + 20% tierra orgánica + 10% de arena); (35% de humus + 35% franco arenoso +20% tierra orgánica + 10% de arena); (35% hojarasca + 35% franco arenoso +20% tierra orgánica + 10% de arena); (25% de humus + 25% de hojarasca + 20% tierra orgánica + 10% de arena) ; (25% de humus + 25% de hojarasca +25% franco arenoso + 20% tierra orgánica + 10% de arena) , más 1 testigos (50% tierra orgánica + 50% arena); en la propagación sexual se evaluó el porcentaje de germinación de las semillas, obteniendo, que el T6 (35% de hojarasca + 35% de franco arenoso + 20 % de tierra orgánica y 10% de arena) alcanzo el mayor porcentaje de germinación con un 30%, alcanzando a los 60 días una altura de 4.2 cm por plántula. Mientras que; en la propagación asexual se realizó: ensayos de enraizamiento de estacas, evaluando el número de brotes, número de raíces, longitud de raíces por estaca; alcanzando el T6 el mayor número de brotes por estaca con 3 brotes; con una longitud de raíces de 4 cm por estaca plantada.</p>