bluuebunny/crossref_metadata_2025_split huggingface dataset:
(g − 2)μ versus K → π + Emiss induced by the (B − L)23 boson
Authors: Kang Zhaofeng , Shigekami Yoshihiro 
Published: April 2021

Abstract
To address the long-standing (g − 2)μ anomaly via a light boson, in ref. [1] we proposed to extend the standard model (SM) by the local (B − L)23, under which only the second and third generations of fermions are charged. It predicts an invisible Z′ with mass $$ \mathcal{O}(100) $$
O

100

MeV, and moreover it has flavor-changing neutral current (FCNC) couplings to the up-type quarks at tree level. Such a Z′, via KL→ π0 + Z′(→$$ v\overline{v} $$
v

v
¯

) at loop level, may be a natural candidate to account for the recent KOTO anomaly. In this article, we investigate this possibility, to find that Z′ can readily do this job if it is no longer responsible for the (g − 2)μ anomaly. We further find that both anomalies can be explained with moderate tuning of the CP violation, but may contradict the B meson decays.
Service robots for affective labor: a sociology of labor perspective
Authors: Dobrosovestnova Anna , Hannibal Glenda , Reinboth Tim 
Published: April 2021

AbstractProfit-oriented service sectors such as tourism, hospitality, and entertainment are increasingly looking at how professional service robots can be integrated into the workplace to perform socio-cognitive tasks that were previously reserved for humans. This is a work in which social and labor sciences recognize the principle role of emotions. However, the models and narratives of emotions that drive research, design, and deployment of service robots in human–robot interaction differ considerably from how emotions are framed in the sociology of labor and feminist studies of service work. In this paper, we explore these tensions through the concepts of affective and emotional labor, and outline key insights these concepts offer for the design and evaluation of professional service robots. Taken together, an emphasis on interactionist approaches to emotions and on the demands of affective labor, leads us to argue that service employees are under-represented in existing studies in human–robot interaction. To address this, we outline how participatory design and value-sensitive design approaches can be applied as complimentary methodological frameworks that include service employees as vital stakeholders.
Geometric Presentations of Braid Groups for Particles on a Graph
Authors: An Byung Hee , Maciazek Tomasz 
Published: April 2021

AbstractWe study geometric presentations of braid groups for particles that are constrained to move on a graph, i.e. a network consisting of nodes and edges. Our proposed set of generators consists of exchanges of pairs of particles on junctions of the graph and of certain circular moves where one particle travels around a simple cycle of the graph. We point out that so defined generators often do not satisfy the braiding relation known from 2Dphysics. We accomplish a full description of relations between the generators for star graphs where we derive certain quasi-braiding relations. We also describe how graph braid groups depend on the (graph-theoretic) connectivity of the graph. This is done in terms of quotients of graph braid groups where one-particle moves are put to identity. In particular, we show that for 3-connected planar graphs such a quotient reconstructs the well-known planar braid group. For 2-connected graphs this approach leads to generalisations of the Yang–Baxter equation. Our results are of particular relevance for the study of non-abelian anyons on networks showing new possibilities for non-abelian quantum statistics on graphs.
18F-Fluorothymidine PET is an early and superior predictor of progression-free survival following chemoimmunotherapy of diffuse large B cell lymphoma: a multicenter study
Authors: Minamimoto Ryogo , Fayad Luis , Vose Julie , Meza Jane , Advani Ranjana , Hankins Jordan , Mottaghy Felix , Macapinlac Homer , Heinzel Alexander , Juweid Malik E. , Quon Andrew 
Published: April 2021

Abstract
Purpose
To determine whether interim 3′-deoxy-3′-[18F]fluorothymidine (iFLT) PET/CT is a superior predictor of progression-free survival (PFS) compared with interim 18F-fluorodeoxyglucose (iFDG) PET/CT in patients with diffuse large B cell lymphoma (DLBCL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH).

Methods
Ninety-two prospectively enrolled patients with DLBCL underwent both FLT-PET/CT and FDG-PET/CT 18–24 days after two cycles of R-CHOP/R-EPOCH. Deauville-criteria, PERCIST1.0, standardized uptake value (SUV), total lesion glycolysis (TLG), and metabolic tumor volume were used to interpret iFDG-PET/CT while dichotomous visual interpretation was used to interpret iFLT-PET/CT and the results were compared with the 3- and 5-year PFS.

Results
iFLT-PET/CT was negative in 67 (73%) and positive in 25 (27%) patients. iFDG-PET/CT by Deauville criteria was negative (Deauville scores [DS] of 1–3) in 53 (58%) and positive (DS = 4–5) in 39 (42%) patients. Of the 67 iFLT-PET/CT-negative patients, 7 (10.4%) progressed at a median of 14.1 months whereas 14/25 (56.0%) iFLT-PET/CT-positive patients progressed at a median of 7.8 months (P < .0001). Of the 53 Deauville-negative patients, 9 (17.0%) progressed at a median of 14.1 months whereas 12/39 (30.8%) Deauville-positive patients progressed at a median of 5.6 months (P = .11). In multivariate analysis, including iFLT-PET/CT, PERCIST, interim TLG, and interim SUVmax, only iFLT-PET/CT was an independent predictor for 3- and 5-year PFS (P < .0001 and P = .001, respectively).

Conclusions
In patients with DLBCL given R-CHOP/R-EPOCH, iFLT-PET/CT is a superior independent predictor of outcome compared with iFDG-PET/CT.
PET/MRI for staging patients with Hodgkin lymphoma: equivalent results with PET/CT in a prospective trial
Authors: Picardi M. , Cavaliere C. , Della Pepa R. , Nicolai E. , Soricelli A. , Giordano C. , Pugliese N. , Rascato M.G. , Cappuccio I. , Campagna G. , Cerchione C. , Vigliar E. , Troncone G. , Mascolo M. , Franzese M. , Castaldo R. , Salvatore M. , Pane F. 
Published: April 2021

AbstractTo compare FDG-PET/unenhanced MRI and FDG-PET/diagnostic CT in detecting infiltration in patients with newly diagnosed Hodgkin lymphoma (HL). The endpoint was equivalence between PET/MRI and PET/CT in correctly defining the revised Ann Arbor staging system. Seventy consecutive patients with classical-HL were prospectively investigated for nodal and extra-nodal involvement during pretreatment staging with same-day PET/CT and PET/MRI. Findings indicative of malignancy with the imaging procedures were regarded as lymphoma infiltration; in case of discrepancy, positive-biopsy and/or response to treatment were evidenced as lymphoma. Sixty of the 70 (86%) patients were evaluable having completed the staging program. Disease staging based on either PET/MRI or PET/CT was correct for 54 of the 60 patients (90% vs. 90%), with difference between proportions of 0.0 (95% CI, −9 to 9%; P=0.034 for the equivalence test). As compared with reference standard, invasion of lymph nodes was identified with PET/MRI in 100% and with PET/CT in 100%, of the spleen with PET/MRI in 66% and PET/CT in 55%, of the lung with PET/MRI in 60% and PET/CT in 100%, of the liver with PET/MRI in 67% and PET/CT in 100%, and of the bone with PET/MRI in 100% and PET/CT in 50%. The only statistically significant difference between PET/MRI and PET/CT was observed in bony infiltration detection rates. For PET/CT, iodinate contrast medium infusions’ average was 86 mL, and exposure to ionizing radiation was estimated to be 4-fold higher than PET/MRI. PET/MRI is a promising safe new alternative in the care of patients with HL.
Evaluation of the mediastinal-thoracic volume ratio on postmortem computed tomography
Authors: Chatzaraki Vasiliki , Ebert Lars C. , Thali Michael J. , Haidich Anna-Bettina , Ampanozi Garyfalia 
Published: April 2021

AbstractObjectivesThe aim of this study was to measure the mediastinal-thoracic volume ratio (CTR_VOL) on PMCT as a more accurate version of traditional CTR, in order to assess the terminal positional relationship between the heart and lungs in the different causes of death with regard to age, gender, BMI, cardiomegaly, and lung expansion.MaterialsTwo hundred fifty consecutive postmortem cases with pre-autopsy PMCT and full forensic autopsy were retrospectively evaluated. The lungs and the mediastinum were manually segmented on the PMCT data and the correspondent volumes were estimated in situ. CTR_VOL was calculated as the ratio of the mediastinal to the thoracic volume. The volume measurements were repeated by the same rater for the evaluation of the intrarater reliability. Age, gender, body weight and height, heart weight at autopsy, and cause of death were retrieved from the autopsy reports. Presence of lung expansion was radiologically evaluated in situ.ResultsCTR_VOL was positively associated with age and BMI but not with gender and was higher for cardiomegaly compared to normal hearts, lower for asphyxiation-related deaths compared to cardiac deaths and intoxications, and lower for cases with lung expansion. The intrarater reliability was excellent for the calculated volumes of both lungs and mediastinum.ConclusionThe results of the present study support CTR_VOL as a tool to assess the relationship between the heart and lungs in situ, which differs significantly between the studied cause of death categories.
Machine learning based multiscale calibration of mesoscopic constitutive models for composite materials: application to brain white matter
Authors: Field Duncan , Ammouche Yanis , Peña José-Maria , Jérusalem Antoine 
Published: April 2021

AbstractA modular pipeline for improving the constitutive modelling of composite materials is proposed.The method is leveraged here for the development of subject-specific spatially-varying brain white matter mechanical properties. For this application, white matter microstructural information is extracted from diffusion magnetic resonance imaging (dMRI) scans, and used to generate hundreds of representative volume elements (RVEs) with randomly distributed fibre properties. By automatically running finite element analyses on these RVEs, stress-strain curves corresponding to multiple RVE-specific loading cases are produced. A mesoscopic constitutive model homogenising the RVEs’ behaviour is then calibrated for each RVE, producing a library of calibrated parameters against each set of RVE microstructural characteristics. Finally, a machine learning layer is implemented to predict the constitutive model parameters directly from any new microstructure. The results show that the methodology can predict calibrated mesoscopic material properties with high accuracy. More generally, the overall framework allows for the efficient simulation of the spatially-varying mechanical behaviour of composite materials when experimentally measured location-specific fibre geometrical characteristics are provided.
Origin, migration and secondary processes of oil and natural gas in the western part of the Polish Outer Carpathians: geochemical and geological approach
Authors: Kotarba Maciej J. , Bilkiewicz Elżbieta , Jurek Krzysztof , Więcław Dariusz , Machowski Grzegorz 
Published: April 2021

AbstractThe origin, migration pathways, as well as the influence of secondary processes of oil and natural gas accumulated in lower Cretaceous to lower Miocene strata of the western part of the Polish Outer Carpathians (between Kraków and Pilzno towns) based on results of organic geochemical analyses are investigated in this paper. Oil and thermogenic hydrocarbon gases were generated mainly from type II kerogen, and type II and III kerogen mixed in various proportions. These kerogens mainly occur in the Oligocene Menilite beds of the Silesian and Dukla nappes. Oils were generated from early to late “oil window”. Secondary cracking was recorded in oils from Dukla nappe, other secondary processes including biodegradation, water washing and evaporative fractionation were also developed to a various extent in many oils. The most biodegraded oils occur in seep S-Li, and the most extensive water washing is observed in the oil from seep S-Sa/1. The evaporative fractionation processes most significantly occur in the selected deepest parts of the multi-horizontal Biecz field. Hydrocarbon gases originated during both microbial and thermogenic processes of organic matter transformation. Natural gas has not been subjected to biodegradation processes. Carbon dioxide is derived from both microbial and thermogenic decomposition processes of organic matter and was generated together with hydrocarbon gases.
Polyphase extensional basins: interplay between tectonics and sedimentation in the Neogene Siena-Radicofani Basin (Northern Apennines, Italy)
Authors: Martini Ivan , Ambrosetti Elisa , Brogi Andrea , Aldinucci Mauro , Zwaan Frank , Sandrelli Fabio 
Published: April 2021

AbstractRift-basins are the shallow effects of lithosphere-scale extensional processes often producing polyphase faulting. Their sedimentary evolution depends on the mutual interplay between tectonics, climate, and eustasy. Estimating the role of each factor is generally a challenging issue. This paper is focused on the tectono-sedimentary evolution of the Neogene Siena-Radicofani Basin, a polyphase structural depression located in the inner Northern Apennines. Since Miocene, this basin developed after prolonged extensional tectonics, first as a bowl-shaped structural depression, later reorganized into a half-graben structure due to the activation of high-angle normal faults in the Zanclean. At that time the basin contained coeval continental and marine settings controlled by the normal faulting that caused the development of local coarse-grained depositional systems. These were investigated to: (i) discriminate between the influences of tectonics and climate on sedimentation patterns, and (ii) provide detailed time constraints on fault activity. The analysed successions were deposited in an interval between 5.08 and 4.52 Ma, when a climate-induced highstand phase occurred throughout the Mediterranean. However, evidence of local relative sea-level drops is registered in the sedimentary record, often associated with increased accommodation space and sediment supply. Such base-level fluctuations are not connected to climate changes, suggesting that the faults generally control sedimentation along the basin margins.
The impact of COVID-19 on the lives and mental health of Australian adolescents
Authors: Li Sophie H. , Beames Joanne R. , Newby Jill M. , Maston Kate , Christensen Helen , Werner-Seidler Aliza 
Published: April 2021

AbstractThere has been significant disruption to the lives and mental health of adolescents during the COVID-19 pandemic. The purpose of this study was to assess the psychological and lifestyle impact of the pandemic on Australian adolescents, using an online survey, administered during the outbreak. Self-report surveys were administered online to a sample of 760 Australian adolescents aged 12–18 years assessing impact on a range of domains including behaviour, education, relationships, lifestyle factors (exercise, technology use, and sleep), and mental health outcomes (psychological distress, loneliness, health anxiety and well-being). Results showed that three quarters of the sample experienced a worsening in mental health, since the pandemic began, with negative impacts reported on learning, friendships and family relationships. There were also high higher levels of sleep disturbance, psychological distress and health anxiety, relative to normative samples. Effects on mental health were worse among those who reported a previous diagnosis of depression and/or anxiety relative to those without no such history. Adolescents are already vulnerable to the onset of mental illness at this developmental stage, and the current research underscores the need to find rapid and accessible ways to support adolescent mental health during times of crisis.
What is the best approach to adopt for identifying the domains for a new measure of health, social care and carer-related quality of life to measure quality-adjusted life years? Application to the development of the EQ-HWB?
Authors: Peasgood Tessa , Mukuria Clara , Carlton Jill , Connell Janice , Devlin Nancy , Jones Karen , Lovett Rosemary , Naidoo Bhash , Rand Stacey , Rejon-Parrilla Juan Carlos , Rowen Donna , Tsuchiya Aki , Brazier John 
Published: April 2021

AbstractEconomic evaluation combines costs and benefits to support decision-making when assessing new interventions using preference-based measures to measure and value benefits in health or health-related quality of life. These health-focused instruments have limited ability to capture wider impacts on informal carers or outcomes in other sectors such as social care. Sector-specific instruments can be used but this is problematic when the impact of an intervention straddles different sectors.An alternative approach is to develop a generic preference-based measure that is sufficiently broad to capture important cross-sector outcomes. We consider the options for the selection of domains for a cross-sector generic measure including how to identify domains, who should provide information on the domains and how this should be framed. Beyond domain identification, considerations of criteria and stakeholder needs are also identified.This paper sets out the case for an approach that relies on the voice of patients, social care users and informal carers as the main source of domains and describes how the approach was operationalised in the ‘Extending the QALY’ project which developed the new measure, the EQ-HWB (EQ health and wellbeing instrument). We conclude by discussing the strengths and limitations of this approach. The new measure should be sufficiently generic to be used to consistently evaluate health and social care interventions, yet also sensitive enough to pick up important changes in quality of life in patients, social care users and carers.
Acorn storage in tree cavities by Eurasian jay (Garrulus glandarius L.)
Authors: Wróbel Aleksandra , Kurek Przemysław , Dobrowolska Dorota 
Published: April 2021

AbstractSeed hoarding by granivorous animals requires cache-protection strategies which allow to protect hoarded seeds against pilferage. This study reports the first case of acorn hoarding in tree cavities by Eurasian Jays (Garrulus glandarius). Out of 116 removed acorns of both pedunculate oak (Quercus robur) and Northern red oak (Q. rubra), we localized 14 consumed and 102 stored acorns. Five experimental acorns (4.9% of stored acorns) were found stored in tree cavities. The notion that hoarding seeds in tree cavities may constitute a cache-protection behavior of Eurasian Jays represents a working hypothesis that ought to be tested in future studies.
Towards Transabdominal Functional Photoacoustic Imaging of the Placenta: Improvement in Imaging Depth Through Optimization of Light Delivery
Authors: Huda Kristie , Swan Kenneth F. , Gambala Cecilia T. , Pridjian Gabriella C. , Bayer Carolyn L. 
Published: April 2021

AbstractFunctional photoacoustic imaging of the placenta could provide an innovative tool to diagnose preeclampsia, monitor fetal growth restriction, and determine the developmental impacts of gestational diabetes. However, transabdominal photoacoustic imaging is limited in imaging depth due to the tissue’s scattering and absorption of light. The aim of this paper was to investigate the impact of geometry and wavelength on transabdominal light delivery. Our methods included the development of a multilayer model of the abdominal tissue and simulation of the light propagation using Monte Carlo methods. A bifurcated light source with varying incident angle of light, distance between light beams, and beam area was simulated to analyze the effect of light delivery geometry on the fluence distribution at depth. The impact of wavelength and the effects of variable thicknesses of adipose tissue and muscle were also studied. Our results showed that the beam area plays a major role in improving the delivery of light to deep tissue, in comparison to light incidence angle or distance between the bifurcated fibers. Longer wavelengths, with incident fluence at the maximum permissible exposure limit, also increases fluence within deeper tissue. We validated our simulations using a commercially available light delivery system and ex vivo human placental tissue. Additionally, we compared our optimized light delivery to a commercially available light delivery system, and conclude that our optimized geometry could improve imaging depth more than 1.6×, bringing the imaging depth to within the needed range for transabdominal imaging of the human placenta.
Minimal Theory of Causation and Causal Distinctions
Authors: Sikorski Michał 
Published: April 2021

AbstractThe Minimal Theory of Causation, presented in Graßhoff and May, 2001, aspires to be a version of a regularity analysis of causation able to correctly predict our causal intuitions. In my article, I will argue that it is unsuccessful in this respect. The second aim of the paper will be to defend Hitchcock’s proposal concerning divisions of causal relations (presented in Hitchcock, 2001) against criticism made, in Jakob, 2006 on the basis of the Minimal Theory of Causation.
Selinexor in combination with topotecan in patients with advanced or metastatic solid tumors: Results of an open-label, single-center, multi‐arm phase Ib study
Authors: Thein Kyaw Zin , Piha-Paul Sarina A. , Tsimberidou Apostolia , Karp Daniel D. , Janku Filip , Zarifa Abdulrazzak , Shah Jatin , Milton Denái R. , Bean Stacie , McQuinn Lacey , Gong Jing , Colen Rivka , Carter Brett W. , Subbiah Vivek , Ogbonna Deby C. , Pant Shubham , Meric-Bernstam Funda , Naing Aung 
Published: April 2021

SummaryBackground Selinexor, a first-in-class, oral selective inhibitor of nuclear export (SINE) compound inhibits Exportin-1(XPO1), had demonstrated synergistic activity with many chemotherapies and conferred in vivo antitumor efficacy in hematologic as well as solid tumors. Methods This open-label, single-center, multi-arm phase 1b study used a standard 3 + 3 design and a “basket type” expansion. Selinexor with intravenous topotecan was given in one of the 13 parallel arms. Patients with advanced or metastatic relapsed/refractory solid tumors following prior systemic therapy, or in whom the addition of selinexor to standard chemotherapy deemed appropriate, were eligible. Results Fourteen patients with the median age of 61 years (range, 22–68years) were treated, and the most common cancer types were gynecological cancers; ovarian (n = 5), endometrial (n = 2), and 1 each with fallopian tube and vaginal cancers. Of the 14 patients treated, 12 (86 %) had at least one treatment-related adverse event (TRAE). The most common TRAEs were anemia (71 %), thrombocytopenia (57 %), hyponatremia (57 %), vomiting (57 %), fatigue (50 %), nausea (50 %), and neutropenia (36 %). Two patients had dose limiting toxicities. One patient dosed at selinexor 80 mg had grade 3 nausea and vomiting and one patient dosed at selinexor 60 mg experienced grade 4 neutropenia and thrombocytopenia. Of the 13 efficacy evaluable patients, one (8 %) with endometrial cancer achieved unconfirmed partial response (uPR) and the time-to-treatment failure (TTF) was 48 weeks, whereas 6 of the 13 (46 %) patients had stable disease (SD) contributing to the clinical benefit rate of 46 %. The median TTF for all patients was 9 weeks (range, 2–48weeks). Conclusions Once weekly selinexor in combination with topotecan was viable and showed some preliminary tumor efficacy. The recommend phase 2 dose of selinexor was 60 mg once weekly in combination with IV topotecan.Trial registration: NCT02419495. Registered 14 April 2015, https://clinicaltrials.gov/ct2/show/NCT02419495