bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nivolumab in combination with cabozantinib for metastatic triple-negative breast cancer: a phase II and biomarker study
Authors: Barroso-Sousa Romualdo , Keenan Tanya E. , Li Tianyu , Tayob Nabihah , Trippa Lorenzo , Pastorello Ricardo G. , Richardson III Edward T. , Dillon Deborah , Amoozgar Zohreh , Overmoyer Beth , Schnitt Stuart J. , Winer Eric P. , Mittendorf Elizabeth A. , Van Allen Eliezer , Duda Dan G. , Tolaney Sara M. 
Published: August 2021

AbstractThis single-arm phase II study investigated the efficacy and safety of cabozantinib combined with nivolumab in metastatic triple-negative breast cancer (mTNBC). The primary endpoint was objective response rate (ORR) by RECIST 1.1. Biopsies at baseline and after cycle 1 were analyzed for tumor-infiltrating lymphocytes (TILs), PD-L1, and whole-exome and transcriptome sequencing. Only 1/18 patients achieved a partial response (ORR 6%), and the trial was stopped early. Toxicity led to cabozantinib dose reduction in 50% of patients. One patient had a PD-L1-positive tumor, and three patients had TILs > 10%. The responding patient had a PD-L1-negative tumor with low tumor mutational burden but high TILs and enriched immune gene expression. High pretreatment levels of plasma immunosuppressive cytokines, chemokines, and immune checkpoint molecules were associated with rapid progression. Although this study did not meet its primary endpoint, immunostaining, genomic, and proteomic studies indicated a high degree of tumor immunosuppression in this mTNBC cohort.
Automated stopping criterion for spectral measurements with active learning
Authors: Ueno Tetsuro , Ishibashi Hideaki , Hino Hideitsu , Ono Kanta 
Published: August 2021

AbstractThe automated stopping of a spectral measurement with active learning is proposed. The optimal stopping of the measurement is realised with a stopping criterion based on the upper bound of the posterior average of the generalisation error of the Gaussian process regression. It is revealed that the automated stopping criterion of the spectral measurement gives an approximated X-ray absorption spectrum with sufficient accuracy and reduced data size. The proposed method is not only a proof-of-concept of the optimal stopping problem in active learning but also the key to enhancing the efficiency of spectral measurements for high-throughput experiments in the era of materials informatics.
Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds
Authors: Dele-Oni Deborah O. , Christianson Karen E. , Egri Shawn B. , Vaca Jacome Alvaro Sebastian , DeRuff Katherine C. , Mullahoo James , Sharma Vagisha , Davison Desiree , Ko Tak , Bula Michael , Blanchard Joel , Young Jennie Z. , Litichevskiy Lev , Lu Xiaodong , Lam Daniel , Asiedu Jacob K. , Toder Caidin , Officer Adam , Peckner Ryan , MacCoss Michael J. , Tsai Li-Huei , Carr Steven A. , Papanastasiou Malvina , Jaffe Jacob D. 
Published: August 2021

AbstractWhile gene expression profiling has traditionally been the method of choice for large-scale perturbational profiling studies, proteomics has emerged as an effective tool in this context for directly monitoring cellular responses to perturbations. We previously reported a pilot library containing 3400 profiles of multiple perturbations across diverse cellular backgrounds in the reduced-representation phosphoproteome (P100) and chromatin space (Global Chromatin Profiling, GCP). Here, we expand our original dataset to include profiles from a new set of cardiotoxic compounds and from astrocytes, an additional neural cell model, totaling 5300 proteomic signatures. We describe filtering criteria and quality control metrics used to assess and validate the technical quality and reproducibility of our data. To demonstrate the power of the library, we present two case studies where data is queried using the concept of “connectivity” to obtain biological insight. All data presented in this study have been deposited to the ProteomeXchange Consortium with identifiers PXD017458 (P100) and PXD017459 (GCP) and can be queried at https://clue.io/proteomics.
Characterizing right-angled vessel in macular telangiectasia type 2 with structural optical coherence tomography
Authors: Chung Yoo-Ri , Kim Young Ho , Oh Jaeryung , Kim Seong-Woo , Lee Christopher Seungkyu , Yun Cheolmin , Lee Boram , Ahn So Min , Choi Eun Young , Jang Sungmin , Lee Kihwang 
Published: August 2021

AbstractWe investigated the structural findings on spectral-domain optical coherence tomography (SD-OCT) related to the presence of right-angled vessels (RAV) in patients with macular telangiectasia (MacTel) type 2 with severity 3 in Korea. A retrospective multicenter cross-sectional study was conducted in six tertiary hospitals in Korea; the study included 116 MacTel type 2 eyes with severity 3. The SD-OCT findings were compared between eyes with RAV on fundus photography or fluorescein angiography and those without RAV. Logistic regression was performed to determine factors associated with the presence of RAV. Fifty eyes presented with RAV and 61 eyes without RAV. More eyes presented with only inner retinal (IR) cavities on SD-OCT among eyes without RAV than among those with RAV (P < 0.001). However, eyes with RAV presented with IR disorganization, outer retinal (OR) cavity, and ellipsoid zone (EZ) disruption more frequently than eyes without RAV did (all P < 0.001). These SD-OCT findings were significantly associated with the presence of RAV. The presence of RAV was closely related to IR disorganization, OR cavities, and EZ disruption on SD-OCT. These findings suggest an advanced phase of MacTel type 2.
Ultrahigh-energy sodium ion capacitors enabled by the enhanced intercalation pseudocapacitance of self-standing Ti2Nb2O9/CNF anodes
Authors: She Liaona , Zhang Feng , Jia Congying , Kang Liping , Li Qi , He Xuexia , Sun Jie , Lei Zhibin , Liu Zong-Huai 
Published: August 2021

Ti2Nb2O9/CNF anode with excellent sodium storage performance is fabricated by electrospinning and carbonization treatment. The assembled Ti2Nb2O9/CNF//AC SIC exhibits a high energy density of 129 W h kg-1 at 75 W kg-1.
Audiologist-Supported Internet-Based Cognitive Behavioral Therapy for Tinnitus in the United States: A Pilot Trial
Authors: Beukes Eldré W. , Andersson Gerhard , Fagelson Marc , Manchaiah Vinaya 
Published: August 2021

BackgroundPatients often report that living with a condition such as tinnitus can be debilitating, worrying, and frustrating. Efficient ways to foster management strategies for individuals with tinnitus and promoting tinnitus self-efficacy are needed. Internet-based cognitive behavioral therapy (ICBT) for tinnitus shows promise as an evidence-based intervention in Europe, but is not available in the United States. The aim of this pilot study was to evaluate the feasibility of an ICBT intervention for tinnitus in the United States.MethodThis study reports the Phase 1 trial intended to support implementation of a larger randomized clinical trial (RCT) comparing ICBT to a weekly monitoring group. As a pilot study, a single-group pretest–posttest design was used to determine outcome potential, recruitment strategy, retention, and adherence rates of ICBT for tinnitus. The primary outcome was a change in tinnitus distress. Secondary outcome measures included measures of anxiety, depression, insomnia, tinnitus cognitions, hearing-related difficulties, and quality of life.ResultsOf the 42 screened participants, nine did not meet the inclusion criteria and six withdrew. There were 27 participants who completed the intervention, with a mean age of 55.48 (± 9.9) years.Feasibility was established, as a large pretest–posttest effect size ofd = 1.6 was found for tinnitus severity. Large pretest–posttest effect sizes were also found for tinnitus cognitions and hearing-related effects, and a medium effect was found for insomnia and quality of life. Treatment adherence varied with a retention rate of 85% (n = 23) at post-intervention assessment and 67% (n = 18) for the follow-up assessment.ConclusionsThis pilot study supported the feasibility of ICBT for tinnitus in the United States. Ways of improving intervention retention and recruitment rates need to be explored in future ICBT studies. Protocol refinements that were identified will be implemented prior to further RCTs to investigate the efficacy of ICBT for tinnitus in the United States.Supplemental Materialhttps://doi.org/10.23641/asha.15501135
Long‐term generation scheduling for renewable‐dominant systems concerning limited energy supporting capability of hydrogeneration
Authors: Lin Yisha , Qiao Ying , Lu Zongxiang 
Published: August 2021

AbstractRenewable‐dominant mixtures with hydrogeneration and variable renewable energies (VREs) have been the focus for decarbonization of power systems. Hydrogeneration with large reservoir becomes the main regulating source. The long‐term generation scheduling (LTGS) on monthly reservoir regulation for the approaching year becomes more significant because reserving adequate water storage is related to intramonth balance, considering that hydrogeneration has to supplement deficit energy of VRE generation. However, conventional LTGS method that is based on monthly averages overestimates the hydrogeneration's intramonth energy supporting capability, whereas rolling short‐term generation scheduling method cannot account the long‐term effect of reservoir regulation decisions. This paper proposes a new LTGS method accounting intramonth imbalance risk that the energy deficit of VRE generation exceeds the maximum supporting energy of hydrogeneration. Since intramonth imbalance risk is coupled with LTGS in an uncertain and implicit way, intramonth extreme scenarios are introduced based on distribution quantiles of natural inflow of reservoirs and VRE generation, and the probabilistic intramonth imbalance risk constraints can be transformed as the hydrogeneration must supplement energy deficit of VRE generation during the extreme scenarios. A case study is conducted on a Wind‐PV‐Hydro energy base of southwestern China. The proposed method is found able to improve the feasibility and reliability of LTGS compared to other LTGS methods. Moreover, the high calculation efficiency of conventional LTGS method is inherited.
Focal cartilage defects of the lateral compartment do influence the outcome after high tibial valgus osteotomy
Authors: Heinz Tizian , Reppenhagen Stephan , Wagenbrenner Mike , Horas Konstantin , Ohlmeier Malte , Schäfer Thomas , Rudert Maximilian , Barthel Thomas , Weißenberger Manuel 
Published: August 2021

Introduction: High tibial medial open-wedge valgus osteotomy (HTO) is a well-established procedure for unicompartimental medial osteoarthritis of the young and active patient. However, the influence of cartilage defects of the lateral compartment on the total outcome remains obscure.Methods: From 2005 to 2012, a total of 63 patients underwent HTO for medial osteoarthritis of the knee at a single university orthopaedic center. Baseline data as well as intraoperative findings, including the grade and location of cartilage lesions, were evaluated retrospectively. Two groups were formed regarding the integrity of the lateral tibiofemoral compartment as measured by the Outerbridge score (group A: no lateral cartilage defects, group B: mild to moderate lateral cartilage defects). Functional outcome was assessed using the Knee and Osteoarthritis Outcome Score (KOOS), including its five subscores.Results: Comparing pre- and postoperative data, we identified an overall benefit of the HTO procedure as measured by the KOOS. Group A (no lateral cartilage defects) showed an increase in all five KOOS subscores (p = 0.00–0.01), whereas for group B (mild to moderate lateral cartilage defects), only two KOOS subscores revealed a significant increase (p = 0.03–0.04). There was also a statistically significant difference in the total KOOS score with higher values for group A at the postoperative visit. Cartilage defects with a higher Outerbridge score were associated with lower postoperative KOOS subscores.Discussion: Mild to moderate cartilage defects of the lateral compartment humble the total outcome after HTO procedure. Thus, indication for HTO should be made very carefully if any degree of lateral cartilage degeneration is present.
Does Age Affect the Short- and Long-Term Outcomes of Coronary Bypass Grafting?
Authors: Anand Pavan Ashwini , Keshavamurthy Suresh , Shelley Ellis M. , Saha Sibu 
Published: August 2021

AbstractThe etiology of coronary artery disease (CAD) is multifactorial, stemming from both modifiable and nonmodifiable risk factors such as age. Several studies have reported the effects of age on various outcomes of coronary artery bypass grafting (CABG). This article reviews age-related outcomes of CABG and offers direction for further studies in the field to create comprehensive, evidence-based guidelines for the treatment of CAD. Ninety-two primary sources were analyzed for relevance to the subject matter, of which 17 were selected for further analysis: 14 retrospective cohort studies, 2 randomized clinical trials, and 1 meta-analysis. Our review revealed four broad age ranges into which patients can be grouped: those with CAD (1) below the age of 40 years, (2) between the ages of 40 and 60 years, (3) between the ages of 60 and 80 years, and (4) at or above 80 years. Patients below the age of 40 years fare best overall with total arterial revascularization (TAR). Patients between the ages of 40 and 60 years also fare well with the use of multiarterial grafts (MAGs) whereas either MAGs or single-arterial grafts may be of significant benefit to patients at or above the age of 60 years, with younger and diabetic patients benefitting the most. Arterial grafting is superior to vein grafting until the age of 80 years, at which point there is promising evidence supporting the continued use of the saphenous vein as the favored graft substrate. Age is a factor affecting the outcomes of CABG but should not serve as a barrier to offering patients CABG at any age from either a cost or a health perspective. Operative intervention starts to show significant mortality consequences at the age of 80 years, but the increased risk is countered by maintenance or improvement to patients' quality of life.
Investigation of Thermal Response of Disc Brake System: A Review
Authors: Thakre Sachin , Shahare Achal , Awari G. K. 
Published: August 2021

Abstract
A comprehensive review of the thermal response of disc brake system has been made. Extensive research has been carried out on the operating problems, the material for the rotor, design of the rotor and the braking conditions of the disc brake systems and numerous methods of improvement are proposed. Various ventilation patterns have been studied in order to enhance thermal efficiency, and structural performance reductions have been found in most cases. Which creates need for the design of discs with optimal thermal and structural characteristics, so that disc brake performance can be enhanced without compromising in strength and other parameters of the disc brake system. It is expected that this exhaustive and comprehensive review will help the research fraternity in identifying the research gaps for their future work. The prime purpose of this paper is to provide an exhaustive overview of developments going on in this field. The proposed research work attempts to develop and modify the system which uses the effective method to minimise the temperature and weight of disc brake rotor by thermo-mechanical analysis to optimise the performance of Disc brake. The proposed design of disc brake offers a promising solution to improve the braking efficiency by 15%and overall reduction in weight of disc brake by 10%.
Review on Reactivity Controlled Compression Ignition Engines: an Approach for BSVI emission Norms
Authors: Kumbhar V S , Shahare Achal , Awari G K 
Published: August 2021

Abstract
In BSVI diesel engines, the limits of the NOx (oxides of nitrogen) and PM (particulate matter) reduced by 68% and 82% as compared to BSIV engines for the category of the vehicle having gross weight less than 3500kg. It is subjected to implement a complex and costly emission reduction system which reduces fuel economy. Reactivity controlled compression ignition (RCCI) is a duel fuel combustion strategy which has great potential to reduce NOx and PM and the need for an advanced after treatment system with enhanced thermal efficiency. The paper reviews potential of the RCCI strategy, to achieve the emission standards of BSVI norms, which reflects the need for cost assessment of existing engines equipped with advanced after treatment technologies.
Design and Development of Modular Arm Cast Using Additive Manufacturing
Authors: Waghmare G , Bagde S , Khan Sabir 
Published: August 2021

Abstract
The plaster cast and fiberglass cast are the popular elbow dislocation treatment method for immobilization. These are relatively heavy, non-removable, and poorly ventilated, hence might create skin diseases, irritation under the cast and joint injury, if not cast properly. It takes long preparation time and cannot be adjusted after casting, which may lead to improper healing in case if the bone gets little shift insidethe cast. In this work, the orthopedics arm cast prototype is designed and fabricated by using additive manufacturing with ABS material. The core concept of the model is the elbow support and modular rings with a specific width added to achieve a specific support length. After properly positioning the patient’s arm the pressure on the arm can be adjustsed by the small clamps with velcro straps. This has advantages over conventional cast that it provide cast adjustments, proper ventilation, washable, and reusable.
Climate Change: A Very Short Introduction
Authors: Maslin Mark 
Published: August 2021

Abstract
Climate Change: A Very Short Introduction examines the science, the history, and the politics of climate change. Drawing on the latest science from the recent IPCC reports, this VSI examines the potential catastrophic impacts of climate change in the future. Global awareness of climate change has grown very rapidly, as shown by the wide support for campaigners like Greta Thunberg and groups like Extinction Rebellion, and the declaration by many governments that we are now in a climate emergency. It is a threat that forces us to examine the whole basis of modern society. This VSI explores the geopolitical, economic, technological, and social solutions to climate change, and argues for new modes of thinking in tackling the climate crisis.
Minimally Invasive Approach for Dorsal Arachnoid Web: 2-Dimensional Operative Video
Authors: Dauleac Corentin , Leroy Henri-Arthur , Assaker Richard 
Published: August 2021

Abstract
A 67-yr-old patient presented with severe paraparesis and lower limb spasticity. The spinal cord magnetic resonance imaging (MRI) revealed the “scalpel sign”
1,2
at the T7 level, suggesting a diagnosis of a dorsal arachnoid web. This video demonstrates a microsurgical technique for the excision of a dorsal arachnoid web with a minimally invasive approach. A paramedian skin incision, understanding the muscular aponeurosis, was performed from T7 to T8. Then, we inserted the tubular dilators until the lamina, to perform a muscle-sparing approach. An expandable tubular retractor of adequate length was passed over the widest dilator and docked into place along the subperiosteal plane. The T7 lamina was drilled, and the resection of the superior and inferior adjacent spine levels was completed with a rongeur. Additional contralateral bone resection was performed after tubular retractor tilt to the midline.
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After dura mater opening, it was carefully suspended and the dorsal arachnoid leaflet was cut to drain the dorsolateral and lateral spinal cisterns.
4
The dorsal arachnoid web was, first, disconnected from its lateral anchorages. It was then gently removed with microsurgical forceps, to help its microdissection from the spinal cord surface. At this step, peculiar attention was paid to limit the traction or displacements of the spinal cord and surrounding vessels. Once the dorsal arachnoid web was removed, the quality of the spinal cord decompression was confirmed by its re-expansion. In conclusion, the minimally invasive approach is a safe and appropriate technique for dorsal arachnoid web excision.
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The patient gave her informed and signed consent for the writing and publication of this article.
Image at 1:00 reused with permission from Castelnovo G et al, Spontaneous transdural spinal cord herniation, Neurology, 2014;82(14):1290.
Chikungunya virus molecular evolution in India since its re-emergence in 2005
Authors: Chaudhary Sakshi , Jain Jaspreet , Kumar Ramesh , Shrinet Jatin , Weaver Scott C , Auguste Albert J , Sunil Sujatha 
Published: August 2021

Abstract
Chikungunya virus (CHIKV), an alphavirus of the Togaviridae family, is among the most medically significant mosquito-borne viruses, capable of causing major epidemics of febrile disease and severe, chronic arthritis. Identifying viral mutations is crucial for understanding virus evolution and evaluating those genetic determinants that directly impact pathogenesis and transmissibility. The present study was undertaken to expand on past CHIKV evolutionary studies through robust genome-scale phylogenetic analysis to better understand CHIKV genetic diversity and evolutionary dynamics since its reintroduction into India in 2005. We sequenced the complete genomes of fifty clinical isolates collected between 2010 and 2016 from two geographic locations, Delhi and Mumbai. We then analysed them along with 753 genomes available on the Virus Pathogen Database and Analysis Resource sampled over fifteen years (2005–20) from a range of locations across the globe and identified novel genetic variants present in samples from this study. Our analyses show evidence of frequent reintroduction of the virus into India and that the most recent CHIKV outbreak shares a common ancestor as recently as 2006.
A Case of MuSK Myasthenia Gravis Presenting With Persistent Respiratory Insufficiency
Authors: Tsai Carolyn , Howard James F. , Mehrabyan Anahit 
Published: August 2021

Abstract
Muscle-specific kinase (MuSK) antibody is seen in 4%–10% of patients with myasthenia gravis (MG), with 40% of these patients reporting bulbar weakness as the initial symptom. We present the case of a 40-year-old woman with MuSK MG whose only presenting symptom was progressive respiratory insufficiency necessitating BiPAP use 16–24 hours daily. She was unresponsive to treatment for cardiac and pulmonary causes and thus referred to neurology. Initial workup directed toward autoimmune and genetic myopathies was unrevealing. MuSK antibodies were positive (60.7 nmol/L, nl 0.00–0.02). Electrodiagnostic studies were unremarkable other than single fiber electromyography which was consistent with a defect in neuromuscular transmission. Treatment with prednisone, plasma exchange, and rituximab led to improvement to reliance on BiPAP only at night. However, her most treatment refractory and quality of life limiting symptom continues to be respiratory insufficiency. Further investigation to better characterize differential response to treatment in this subset of patients with MuSK MG may be needed.