bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skema network coding dan teknik pemilihan relay pada modul WARP di lingkungan indoor
Authors: Hidayati Nurul , Wijayanti Rieke Adriati , Yulianto Ahmad Wilda , Marya Dianthy , Suja'i Muhammad Syirajuddin 
Published: April 2021

Abstrak
Banyak cara untuk mengetahui keberadaan para dosen dan mahasiswa pada saat aktifitas perkuliahan, mulai dari cara lama menggunakan kertas lembar presensi, menggunakan barcode hingga cara yang sudah terkomputerisasi. Dan permasalahan yang sering timbul dalam Politeknik Negeri Malang adalah perhitungan absensi yang memakan waktu lama dan membutuhkan usaha ekstra untuk merekap data dari lembar absensi mahasiswa pada setiap kelas. Pada penelitian ini, sistem absensi akan menggunakan teknologi RFID (Radio Frequency Identification). Dimana setiap dosen dan mahasiswa akan memliki tag RFID dengan nomor identitas masing-masing yang akan digunakan untuk melakukan absensi. Tag RFID tersebut akan dipindai dan data yang didapat akan disimpan pada database berupa nama, tanggal, hari, jam hadir dan jam keluar. Dari data tersebut akan diolah shingga dapat diketahui jumlah kehadiran dosen, absensi, dan jumlah kompensasi dari mahasiswa. Pada penelitian ini kinerja, kecepatan, jarak jangkau dan ketahanan dari noise diteliti menggunakan aplikasi Wireshark. Dan didapatkan bahwa sistem dapat berjalan dengan waktu yang sangat singkat, waktu rata-rata yang digunakan untuk mengirimkan data adalah 447ms dan masih dapat bekerja meskipun terhalang oleh kertas dengan ketebalan dibawah 2.8cm. Sehingga dengan menggunakan aplikasi ini, proses absensi dan proses perhitungan kompensasi yang semula cukup lama dan membutuhkan usaha ekstra dapat dilakukan dengan cepat dan efisien.

Abstract
There are many ways to find out the whereabouts of lecturers and students during lecture activities, like using old method by writing in presence sheet paper, using barcodes or using computerized methods. And the problem that often arises in the State Polytechnic of Malang is the calculation of attendance which takes a long time and requires extra effort to recap the data from student attendance sheets in each class. In this study, the attendance system will use RFID (Radio Frequency Identification) technology. Where each lecturer and student will have an RFID tag with their respective identity numbers which will be used for attendance. The RFID tag will be scanned and the data obtained will be stored in the database in the form of name, date, day, time of attendance and time out. From this data, it will be processed so that it can be seen the number of lecturers' attendance, attendance, and the amount of compensation for each students. In this study, the performance, speed, range and resistance of noise were examined using the Wireshark application. And it was found that the system can run in a very short time, the average time used to transmit data is 447ms and can still work even though it is hindered by paper with a thickness below 2.8cm. so that by using this application, the attendance process and the process of calculating compensation, which were quite long and required extra effort, can be done quickly and efficiently.
Desain sensor massa menggunakan metode macrobending fiber optic
Authors: Junus Mochammad , Prasetyo Yoyok Heru 
Published: April 2021

Kecepatan dalam hal pengiriman data dan komunikasi merupakan hal terus menerus harus diperbaiki dalam era ini. Beberapa permasalahan dapat timbul karena adanya keterlambatan pengiriman data baik itu bertujuan untuk komunikasi atau pengiriman data pengukuran untuk keperluan tertentu. Salah satu solusi yang dapat di lakukan adalah dengan menggunakan fiber optik. Fiber optik kerap digunakan karena keunggulannya dalam kecepatannya dalam hal komunikasi dan pengiriman data. Saat ini, selain untuk berkomunikasi, fiber optik juga banyak dikembangkan di berbagai keperluan. Salah satunya adalah dalam pengiriman data sensor. Penelitian ini mengangkat topik permasalahan yaitu bagaimana mendesain sebuah sensor massa, dengan menggunakan fiber optik sebagai sensor massa dengan memanfaatkan metode macrobending. Kabel yang digunakan pada penelitian ini menggunakan tipe patch core singlemode FC to FC yang dililit dengan variasi 1,3,5,7, dan 9 kali lilitan pada selang elastis berdiamter ¼ inchi, ½ inchi, 5/8 inchi, ¾ inchi dan 1 inchi dengan massa 0,1 Kg- 10 Kg dengan range 200gram. Untuk input menggunkan OLS (Optical light Source) dengan nilai -7 dBm dan nilai output di terima dan dibaca oleh OPM (Optical Power Meter). Dari hasil pengukuran diperoleh nilai daya output, loss, losses macrobending, dan rugi-rugi tekanan. Dari penelitian ini, hasil yang didapatkan adalah sebuah rumus matematis hubungan antara beban atau massa dengan rugi-rugi tekanan pada kabel fiber optik.
Speed ​​in terms of data transmission and communication is something that must continuously be improved in this era. Several problems can arise due to delays in sending data, either for communication purposes or for sending measurement data for certain purposes. One solution that can be done is to use optical fiber. Optical fiber is often used because of its superiority in speed in terms of communication and data transmission. Currently, in addition to communicating, optical fiber is also being developed for various purposes. One of them is in sending sensor data. This research raises the topic of the problem, namely how to design a mass sensor, using optical fiber as a mass sensor by utilizing the macrobending method. The cables used in this study used a single patch core type FC to FC wrapped with variations of 1,3,5,7, and 9 turns on elastic hoses with diameters of ¼ inch, ½ inch, 5/8 inch, ¾ inch and 1 inch. with a mass of 0.1 kg - 10 kg with a range of 200 grams. For input using an OLS (Optical light Source) with a value of -7 dBm and the output value is received and read by the OPM (Optical Power Meter). From the measurement results obtained the value of output power, loss, macrobending losses, and pressure losses. From this research, the results obtained are a mathematical formula for the relationship between load or mass and pressure losses on fiber optic cables.
Rancangbangun Catu Daya Linier 5V, 12V dengan ZCD dan PWM
Authors: Sarwiji Fathoni , Pracoyo Agus , Sumarno Agus Sukoco Heru 
Published: April 2021

Penelitian ini dilakukan untuk mendapatkan sebuah prototype rangkaian catu daya linier yang dilengkapi dengan rangkaian zero crossing detector dan pembangkit PWM yang dapat digunakan sebagai pelengkap modul praktikum elektronika daya, terutama pada percobaan pengendaliaaan beban ac dengan TRIAC secara digital. Pemicuan dapat dilakukan berdasar sudut fasa, yang memerlukan pulsa ZCD dan pemicuan on-off yang memerlukan PWM. Catu daya linier dipilih dalam rancangbangun ini dengan alasan kemudahan perhitungan rancangan dan mempunyai gangguaninterferensi frekuensi radio yang rendah. Tegangan output catu daya linier adalah 5V dan 12V dengan arus output hingga 1.000 mA. Komponen utama rangkaian catu daya linier adalah regulator IC type LM78XX dengan penguat arus transistor type pnp. Pembangkitan PWM dilakukan dengan kendali ATmega328. Frekuensi output dapat dipilih dari 1dan 2 Hz serta variasi duty cycle, 0,2, 05, 07 dan 1. Pemilihan nilai frekuensi dan duty cycle dilakukan dengan rotary encoder switch. Pulsa output rangkaian ZCD dan PWM dirancang untuk standar TTL. Berdasar peruntukannya maka perangkat catu daya linier ini dilengkapi dengan pengaman hubung singkat pada jalur keluarannya.
This research was conducted to obtain a linear power supply circuit prototype equipped with a zero crossing detector circuit and a PWM generator that can be used as a complement to the power electronics practicum module, especially in the experiment of digitally control loads with a TRIAC. Triggering can be done based on phase angle, which requires ZCD pulses and on-off triggering which requires PWM. The linear power supply was chosen in this design for the reason that it is easy to calculate the design and has low radio frequency interferency. The output voltage of the linear power supply is 5V and 12V with an output current of up to 1,000 mA. The main component of the linear power supply circuit is the LM78XX type regulator IC with a PNP type transistor current amplifier. PWM generation is carried out by controlling the ATmega328.The output frequency can be selected from 1 and 2 Hz as well as variations of the duty cycle, 0.2, 05, 07 and 1. The selection of the frequency and duty cycle values ​​is done by a rotary encoder switch. The output pulses of the ZCD and PWM circuits are designed for the TTL standard. Based on its designation, this linear power supply device is equipped with a safety short circuit on its output line.
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential
Authors: Wu Haiyang , Wang Yulin , Tong Linjian , Yan Hua , Sun Zhiming 
Published: April 2021

Background: Ferroptosis is a newly proposed form of programmed cell death, and accumulating evidence suggests that it plays an essential role in the development of multiple diseases, especially cancers and neurodegenerative diseases. Since officially named in 2012, research on ferroptosis has grown rapidly. There are previous reviews focused on the research progress of ferroptosis from a certain aspect, but no bibliometric studies summarizing this field as a whole. This study aimed to assess the scientific output and activity regarding ferroptosis research from a global perspective.Methods: Publications related to ferroptosis from 2012 to 2020 were identified and selected from the Web of Science Core Collection. Excel 2019 and GraphPad Prism 8.0 was used to analyze quantitative variables including number of publications and citations, H-index, and journal citation reports. VOS viewer and CiteSpace were used to perform co-authorship, co-citation, and co-occurrence analysis of countries/institutes/authors/keywords.Results: A total of 1,285 publications on ferroptosis research were identified. The literature on ferroptosis had been continuously growing since 2012, and the expansion might continue at a rapid pace in the following years. China contributed the greatest proportion (43.74%) of ferroptosis publications, and the United States ranked first in the number of citation frequency (20,980 times) and H-index (70). B. R. Stockwell, D. L. Tang, and R. Kang were key researchers. The journal Cell Death Disease published the highest number of articles, with 42 articles. All the keywords could be divided into two clusters: cluster 1 (pathway and mechanism) and cluster 2 (treatment and effect). In terms of potential hotspots, keywords with the strong bursts and still ongoing recently were “neurodegeneration” (2017–2020), “chemotherapy” (2017–2020), “NF-kappa B” (2017–2020), and “photodynamic therapy” (2018–2020).Conclusion: There will be a dramatically increasing number of publications on ferroptosis research based on the current global trends. China has made significant progress in ferroptosis research, but the United States is actually dominated in this field. More focus will be placed on neurodegeneration, chemotherapy, nuclear factor κB, and photodynamic therapy, which may be the next popular topics in ferroptosis research.
Estimating Contact Rates Between Metarhizium anisopliae–Exposed Males With Female Aedes aegypti
Authors: Reyes-Villanueva Filiberto , Russell Tanya L. , Rodríguez-Pérez Mario A. 
Published: April 2021

IntroductionEffective control of Aedes aegypti will reduce the frequency and severity of outbreaks of dengue, chikungunya, and Zika; however, control programs are increasingly threatened by the rapid development of insecticide resistance. Thus, there is an urgent need for novel vector control tools, such as auto-dissemination of the entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana. The aim of this study was to estimate contact rates of M. anisopliae-exposed males with wild female Ae. aegypti. As a control the contact rates of untreated males with wild females was contrasted.MethodsThe study was conducted in Reynosa, Mexico. The treatment and control households (n = 15 per group) were geographically separated by an arid and hot area that naturally prevented the flight of males between arms. In each control household, 40 M. anisopliae-exposed male Ae. aegypti were released per week for 8 weeks (specimens were exposed to a concentration of 5.96 × 107 conidia/cm2 for 24 h; n = 4,800 males). In each control household, 40 untreated males were released per week for 8 weeks (n = 4,800 males). All specimens were dust-marked prior to release. Mosquito abundance was monitored with human landing collections, and captured Ae. aegypti were examined for any dust-marking.ResultsIn the treatment households, the contact rate of Ae. aegypti females with marked, fungus-treated males was 14% (n = 29 females marked from 197). Where in the control households, the contact rate of females with marked, untreated males was only 6% (n = 22 marked from 365). In the treatment households the recapture rate of released males was at 5% and higher than that for the control households (which was 2%). Auto-dissemination of M. anisopliae from infected males to female Ae. aegypti was demonstrated through the recovery of an infected female from the floor of a household.ConclusionsOverall, the contact rate between M. anisopliae-infected males with the natural female population was 60% higher than for the control group of healthy males. The results provide further support to the release of fungus-exposed males as a potentially useful strategy against Ae. aegypti, though further research is required.
Clinical and Functional Characterization of Novel INSR Variants in Two Families With Severe Insulin Resistance Syndrome
Authors: Zhou Qiaoli , Yu Jing , Yuan Xuewen , Wang Chunli , Zhu Ziyang , Zhang Aihua , Gu Wei 
Published: April 2021

ObjectiveDefects in the insulin receptor (INSR) gene cause various severe insulin resistance conditions, including Donohue syndrome (DS), Rabson-Mendenhall syndrome (RMS) and type A insulin resistance (type A-IR). This study aimed to investigate the clinical characterization and molecular defects in three Chinese children with INSR-related insulin resistance syndrome.MethodsWe reviewed the clinical data of three Chinese children with INSR-related insulin resistance syndrome from two unrelated kindreds. Genetic analysis was performed using whole-exome sequencing and the effects of the novel variants were further assessed by in vitro functional assays.ResultsThe proband with type A-IR presented with acanthosis nigricans, hypertrichosis, and euglycemia with mild insulin resistance in early childhood. His sister presented with features typical of type A-IR and was diagnosed with diabetes mellitus with severe insulin resistance at the age of 9.8 years. The proband with DS showed typical dysmorphic characteristics, severe intrauterine growth retardation, extreme insulin resistance, fasting hypoglycemia and postprandial hyperglycemia from birth. The heterozygote variants c.[3670G&gt;A]; c.[3614C&gt;T] were identified in both siblings with type A-IR; and c.[749_751del]; c.[3355C&gt;T] in the patient with DS. In vitro studies showed that the novel variant c.749_751del [p.(Thr250del)] in the α-subunit, reduced expression of the mature INSR protein and severely impaired INSR function. In contrast, the novel variant c.3670G&gt;A [p.(Val1224Met)] in the β-subunit had no effect on total protein expression and phosphorylation of INSR and Akt, suggesting that the variant p.Val1224Met appeared to be tolerated and was not responsible for the severe insulin resistance.ConclusionOur study detailed the clinical features of three patients with type A-IR and DS, and identified two novel variants in the INSR gene. Functional assays indicated the novel variant p.Thr250del was pathogenic. In contrast, the novel variant p.Val1224Met was suggested to be tolerated by our experimental data, even though bioinformatics analyses predicted the variant as deleterious.
Trans Fatty Acid Intake Induces Intestinal Inflammation and Impaired Glucose Tolerance
Authors: Okamura Takuro , Hashimoto Yoshitaka , Majima Saori , Senmaru Takafumi , Ushigome Emi , Nakanishi Naoko , Asano Mai , Yamazaki Masahiro , Takakuwa Hiroshi , Hamaguchi Masahide , Fukui Michiaki 
Published: April 2021

Background and AimsMany nutritional and epidemiological studies have shown that high consumption of trans fatty acids can cause several adverse effects on human health, including cardiovascular disease, diabetes, and cancer. In the present study, we investigated the effect of trans fatty acids on innate immunity in the gut by observing mice fed with a diet high in trans fatty acids, which have been reported to cause dysbiosis.MethodsWe used C57BL6/J mice and fed them with normal diet (ND) or high-fat, high-sucrose diet (HFHSD) or high-trans fatty acid, high-sucrose diet (HTHSD) for 12 weeks. 16S rRNA gene sequencing was performed on the mice stool samples, in addition to flow cytometry, real-time PCR, and lipidomics analysis of the mice serum and liver samples. RAW264.7 cells were used for the in vitro studies.ResultsMice fed with HTHSD displayed significantly higher blood glucose levels and advanced fatty liver and intestinal inflammation, as compared to mice fed with HFHSD. Furthermore, compared to mice fed with HFHSD, mice fed with HTHSD displayed a significant elevation in the expression of CD36 in the small intestine, along with a reduction in the expression of IL-22. Furthermore, there was a significant increase in the populations of ILC1s and T-bet-positive ILC3s in the lamina propria in mice fed with HTHSD. Finally, the relative abundance of the family Desulfovibrionaceae, which belongs to the phylum Proteobacteria, was significantly higher in mice fed with HFHSD or HTHSD, than in mice fed with ND; between the HFHSD and HTHSD groups, the abundance was slightly higher in the HTHSD group.ConclusionsThis study revealed that compared to saturated fatty acid intake, trans fatty acid intake significantly exacerbated metabolic diseases such as diabetes and fatty liver.
Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation
Authors: Della-Torre Emanuel , Lanzillotta Marco , Campochiaro Corrado , Cavalli Giulio , De Luca Giacomo , Tomelleri Alessandro , Boffini Nicola , De Lorenzo Rebecca , Ruggeri Annalisa , Rovere-Querini Patrizia , Castagna Antonella , Landoni Giovanni , Tresoldi Moreno , Ciceri Fabio , Zangrillo Alberto , Dagna Lorenzo 
Published: April 2021

BackgroundRestraining maladaptive inflammation is considered a rationale strategy to treat severe coronavirus disease-19 (COVID-19) but available studies with selective inhibitors of pro-inflammatory cytokines have not provided unequivocal evidence of survival advantage. Late administration is commonly regarded as a major cause of treatment failure but the optimal timing for anti-cytokine therapy initiation in COVID-19 patients has never been clearly established.ObjectivesTo identify a window of therapeutic opportunity for maximizing the efficacy of interleukin (IL)-1 and IL-6 blockade in COVID-19.MethodsSurvival at the longest available follow-up was assessed in severe hyper-inflamed COVID-19 patients treated with anakinra, tocilizumab, sarilumab, or standard of care, stratified according to respiratory impairment at the time of treatment initiation.Results107 patients treated with biologics and 103 contemporary patients treated with standard of care were studied. After a median of 106 days of follow-up (range 3-186), treatment with biologics was associated with a significantly higher survival rate compared to standard therapy when initiated in patients with a PaO2/FiO2 ≥ 100 mmHg (p &lt; 0.001). Anakinra reduced mortality also in patients with PaO2/FiO2 &lt; 100 mmHg (p = 0.04).ConclusionsIL-1 and IL-6 blocking therapies are more likely to provide survival advantage in hyper-inflamed COVID-19 patients when initiated before the establishment of severe respiratory failure.
Case Report: An Adult Patient With Deficiency of Adenosine Deaminase 2 Resembled Unilateral Frosted Branch Angiitis
Authors: Xu Yufeng , Shan Yi , Hu Yin , Cao Jing , Wang Yijie , Lou Lixia , Ye Panpan 
Published: April 2021

Purpose: Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive systemic autoinflammatory disorder. We describe a rare case of an adult patient with DADA2 who presented with unilateral frosted branch angiitis (FBA) combined with branch retinal vein occlusion and panuveitis.Method: This paper is a clinical case report.Results: A 31-year-old male patient complained of blurred vision in his right eye for 2 days. His fundus examination showed FBA combined with branch retinal vein occlusion and panuveitis. He had a medical history of intermittent and recurrent fever, skin rash and aphthous ulcer for 5 years, and lacunar infarction for 1 month. Laboratory examinations showed hypogammaglobulinemia and mild prolonged activated partial thromboplastin time (APTT). Brain magnetic resonance imaging (MRI) revealed old lacunar infarction in the right basal ganglia and the lateral ventricle and fresh lacunar infarction in the right pons, respectively. The perivascular sheathing of FBA and macular edema were resolved after steroid administration and treatment of intravitreal anti-VEGF injection. During the period of follow-up, the patient subsequently suffered from recurrence of strokes, abnormality of coagulation function, sudden hearing loss of the left ear, and diplopia. His gene sequencing results demonstrated several deletion mutations in ADA2, and the diagnosis of DADA2 was eventually confirmed.Conclusions: FBA represents a very rare ocular feature of DADA2 and may in some cases be the presenting manifestation. Therefore, ophthalmologists need to be aware of this rare autoinflammatory disease.
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
Authors: Abdel-Razik Ahmed , Mousa Nasser , Shabana Walaa , Yassen Ahmed H. , Abdelsalam Mostafa , Wahba Mohamed M. , Helmy Eman Mohamed , Tawfik Ahmed M. , Zalata Khaled , Hasan Ahmad S. , Elhelaly Rania , Elzehery Rasha , Fathy Aya Ahmed , El-Wakeel Niveen , Eldars Waleed 
Published: April 2021

Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD.Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined.Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P &lt; 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P &lt; 0.001) at cutoff values of &gt; 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P &lt; 0.001) at cutoff values of &gt;7.5.Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis.