bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbedaan Penurunan Emesis Gravidarum dengan Minuman Jahe dan Aromaterapi Lemon di Tapos Depok
Authors: Kumaladewi Fazar , Uci Ciptiasrini 
Published: February 2021

Emesis gravidarum adalah gejala yang wajar atau sering terdapat pada kehamilan trimester pertama. Gejala-gajala ini biasanya terjadi 6 minggu setelah hari pertama haid terakhir dan berlangsung kurang lebih 10 minggu. Mual biasanya terjadi pada pagi hari, tetapi ada yang timbul setiap saat dan malam hari. Terapi yang digunakan untuk mengurangi rasa mual muntah ini biasanya dengan terapi farmakologis dan non farmakologis. Terapi non farmakologis yang dapat digunakan untuk mengurangi mual muntah adalah minuman sari jahe dan aromaterapi lemon. Tujuan Penelitian ini adalah untuk mengetahui penurunan tingkat emesis gravidarum pada ibu hamil trimester 1 dengan pemberian minuman sari jahe dan aromaterapi lemon di wilayah kerja puskesmas Kecamatan Tapos Kota Depok. Penelitian ini menggunakan rancangan penelitian true experiment design dengan bentuk pretest posttest design. Sampel pada penelitian ini adalah ibu hamil trimester 1 yang mengalami emesis gravidarum diambil secara quota sampling dari beberapa kriteria inklusi. Hasil dari penelitian ini yaitu terdapat perbedaan penurunan emesis gravidarum sebelum dan sesudah pemberian minuman sari jahe maupun aromaterapi lemon pada ibu hamil trimester 1, dengan nilai p value 0,000. Tenaga kesehatan dapat memberikan terapi non farmakologis kepada ibu hamil trimester 1 yang mengalami emesis gravidarum untuk mengurangi mual muntah.
Pemanfaatan Limbah Kolam Lele dan Bacillus sp untuk meningkatkan pertumbuhan dan hasil Padi (Oryza sativa)
Authors: Rahayuningsih Tri 
Published: February 2021

Abstract— Catfish pond waste has a high content of organic matter and nutrients (nitrogen) which can be used as a source of nutrition for rice plants, but on the other hand it also contains ammonia which can interfere with rice growth. Therefore, research is needed to reduce the negative effects of using catfish pond waste. in rice cultivation, by utilizing Bacillus sp. The purpose of this research is to obtain information about how to use catfish pond waste for rice cultivation, by utilizing the Bacillus sp. Bacteria. Bacillus sp is thought to increase nutrient availability for rice. The method to be carried out in this study used a randomized block design with treatment A0 (control), A1 (Bacillus sp), A2 (catfish waste), A3 (catfish waste + Bacillus sp), A4 (Urea fertilizer). The results of this study found that pond waste and Bacillus sp. Affected the growth and yield of rice. The highest results were obtained in the combination treatment of pond waste with Bacillus sp. Keywords—: Bacillus sp; catfish pond waste; organic rice.
Analisis Loyalitas Agen Biasa dan Agenstok Menggunakan Model RFM (Recency,Frequency, Monetery) dan Algoritma K-Medoids pada BC 4 HPAI Pekanbaru
Authors: Monalisa Siti , Erza Imelda 
Published: February 2021

PT.Herbal Penawar Alwahida Indonesia (HPAI) merupakan perusahaan bisnis halal network di Indonesia yang fokus pada produk-produk herbal. Salah satu BC (Bussines center) HPAI yang terdapat di pekanbaru yaitu,BC 4 HPAI beralamat dijalan Melati III No.4 Bina Widya,Panam. Berdasarkan obeservasi yang dilakukan, data transaksi pelanggan pada tahun 2019 di BC 4 mencapai 1000-2000 transaksi setiap bulannya, yang terdiri dari data agen biasa dan agenstok. Berdasarkan wawancara dengan owner BC 4 HPAI Pekanbaru, masalah yang terjadi yaitu pihak BC 4 HPAI belum bisa mendapatkan informasi dari setiap data agen biasa dan agen stok,mana pelanggan yang potensial dan loyal terhadap perusahaan. Sehingga menyebabkan pihak BC akan sulit untuk menentukan strategi pemasaran yang tepat dalam memanfaatkan kesempatan atau peluang yang ada dalam pemasaran. Mengatasi permasalahan tersebut, penelitian ini menerapkan strategi customer Relationship Management (CRM) yaitu menggunakan Metode RFM untuk mengetahui karakteristik atau prilaku agen biasa dan agenstok kemudian Clustering menggunakan Agoritma K-Medoids untuk pengelompokan sesuai kemiripan karakteristik agenbiasa dan agenstok yang telah didapat sebelumnya. Dengan percobaan 2 cluster sampai dengan 7 cluster, menghasilkan 2 Cluster Terbaik agen biasa dan 3 Cluster Terbaik agenstok berdasarkan DBI (Davies Bouldin Index). Dengan masing-masing nilai DBI terbaik 0.228 agen biasa dan 0.234 agenstok. Hasil tertinggi 2 cluster agen biasa berada pada cluster 1 dengan tipe pelanggan Superstar yang memiliki 472 customer loyal. dan hasil tertinggi dari 3 cluster agenstok berada pada cluster 3 dengan tipe pelanggan Superstar yang memiliki 60 customer loyal.
Innate Immune Responses of Galleria mellonella to Mycobacterium bovis BCG Challenge Identified Using Proteomic and Molecular Approaches
Authors: Asai Masanori , Sheehan Gerard , Li Yanwen , Robertson Brian D. , Kavanagh Kevin , Langford Paul R. , Newton Sandra M. 
Published: February 2021

The larvae of the insect Galleria mellonella, have recently been established as a non-mammalian infection model for the Mycobacterium tuberculosis complex (MTBC). To gain further insight into the potential of this model, we applied proteomic (label-free quantification) and transcriptomic (gene expression) approaches to characterise the innate immune response of G. mellonella to infection with Mycobacterium bovis BCG lux over a 168 h time course. Proteomic analysis of the haemolymph from infected larvae revealed distinct changes in the proteome at all time points (4, 48, 168 h). Reverse transcriptase quantitative PCR confirmed induction of five genes (gloverin, cecropin, IMPI, hemolin, and Hdd11), which encoded proteins found to be differentially abundant from the proteomic analysis. However, the trend between gene expression and protein abundance were largely inconsistent (20%). Overall, the data are in agreement with previous phenotypic observations such as haemocyte internalization of mycobacterial bacilli (hemolin/β-actin), formation of granuloma-like structures (Hdd11), and melanization (phenoloxidase activating enzyme 3 and serpins). Furthermore, similarities in immune expression in G. mellonella, mouse, zebrafish and in vitro cell-line models of tuberculosis infection were also identified for the mechanism of phagocytosis (β-actin). Cecropins (antimicrobial peptides), which share the same α-helical motif as a highly potent peptide expressed in humans (h-CAP-18), were induced in G. mellonella in response to infection, giving insight into a potential starting point for novel antimycobacterial agents. We believe that these novel insights into the innate immune response further contribute to the validation of this cost-effective and ethically acceptable insect model to study members of the MTBC.
Radiation Exposure Reduction and Patient Outcome by Using Very Low Frame Rate Fluoroscopy Protocol (3.8 + 7.5 fps) During Percutaneous Coronary Intervention
Authors: Gupta Ankush , Chhikara Sanya , Vijayvergiya Rajesh , Barwad Parag , Prasad Krishna , Datta Rajat , Mahesh Nalin K. , Maurya Preetika , Singh Navreet 
Published: February 2021

Objectives: In this study, we intend to analyze the feasibility and efficacy of very low frame rate fluoroscopy (VLFF) protocol using a combination of 3.8 and 7.5 fps while performing Percutaneous Coronary Intervention (PCI).Methods: A retrospective cohort including 193 patients undergoing PCI under the VLFF protocol (Post-VLFF group) was compared with a retrospective cohort of 133 patients, who underwent PCI prior to implementation of VLFF protocol (Pre-VLFF group). In the Pre-VLFF group, all PCIs were performed using fluoroscopy frame rate of 15 fps. In the Post-VLFF group, 3.8 fps was used to guide catheter engagement, coronary lesion wiring, pre-and post-dilation, and 7.5 fps was used for lesion assessment and stent placement. Increasing use of fluoroscopic storage in place of cineangiography was also encouraged. Cine acquisition in both groups was performed at 15 fps. Primary endpoint was radiation exposure measured by Air Kerma. Secondary endpoints were procedure related outcomes and patient related outcomes (Major Adverse Cardiac Events including all-cause mortality, Target Lesion Failure, Myocardial Infarction, and Stroke).RESULTS: Post-VLFF group showed 74.7% reduction in Air Kerma as compared to Pre-VLFF group (433 ± 27 mGy vs. 1,714 ± 140 mGy; p &lt; 0.0001), with no increase in the fluoroscopy time (15.38 ± 0.98 min Post-VLFF vs. 17.06 ± 1.29 min Pre-VLFF; p = 0.529) and contrast volume (116.5 ± 4.9 ml Post-VLFF vs. 116.7 ± 6 ml Pre-VLFF; p = 0.700). Both groups had comparable procedural success and complications rates as well as incidence of MACE.Conclusions: The very low frame rate fluoroscopy protocol is a feasible, effective, and safe method to significantly reduce the radiation exposure during PCI without any compromise on procedural and patient outcomes.
Ethnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review
Authors: Kotlyar Alexander M. , Seifer David B. 
Published: February 2021

Purpose of ReviewIn this review, we summarize ethnic/race- and age-related variation in AMH and discuss the underpinnings behind these differences.Recent findingsAnti-mullerian hormone (AMH) has become a widely used method of ovarian reserve testing over the last 15 years. Numerous studies have shown substantial ethnic/race and age-related differences. When compared to age-matched Caucasian women, AMH levels tend to be lower in black and Hispanic women. Chinese women tend to have significantly greater AMH levels prior to age 25 than Caucasian women. When considering subpopulations within ethnicities, at least one study noted lower AMH levels among Maya women compared to other Hispanic women. Age exhibits a positive trend with AMH up until at least 25 years of age with a consistent decline after 34 years of age extending to menopause.SummaryAMH levels are highly variable among ethnicities and race with higher age-matched levels typically seen in Caucasian women. Age does not exhibit a consistent linear relationship with AMH, but a consistent decline is seen starting in the third decade of life and proceeding to menopause.
Knee Cartilage Thickness Differs Alongside Ages: A 3-T Magnetic Resonance Research Upon 2,481 Subjects via Deep Learning
Authors: Si Liping , Xuan Kai , Zhong Jingyu , Huo Jiayu , Xing Yue , Geng Jia , Hu Yangfan , Zhang Huan , Wang Qian , Yao Weiwu 
Published: February 2021

Background: It was difficult to distinguish the cartilage thinning of an entire knee joint and to track the evolution of cartilage morphology alongside ages in the general population, which was of great significance for studying osteoarthritis until big imaging data and artificial intelligence are fused. The purposes of our study are (1) to explore the cartilage thickness in anatomical regions of the knee joint among a large collection of healthy knees, and (2) to investigate the relationship between the thinning pattern of the cartilages and the increasing ages.Methods: In this retrospective study, 2,481 healthy knees (subjects ranging from 15 to 64 years old, mean age: 35 ± 10 years) were recruited. With magnetic resonance images of knees acquired on a 3-T superconducting scanner, we automatically and precisely segmented the cartilage via deep learning and calculated the cartilage thickness in 14 anatomical regions. The thickness readings were compared using ANOVA by considering the factors of age, sex, and side. We further tracked the relationship between the thinning pattern of the cartilage thickness and the increasing ages by regression analysis.Results: The cartilage thickness was always thicker in the femur than corresponding regions in the tibia (p &lt; 0.05). Regression analysis suggested cartilage thinning alongside ages in all regions (p &lt; 0.05) except for medial and lateral anterior tibia in both females and males (p &gt; 0.05). The thinning speed of men was faster than women in medial anterior and lateral anterior femur, yet slower in the medial patella (p &lt; 0.05).Conclusion: We established the calculation method of cartilage thickness using big data and deep learning. We demonstrated that cartilage thickness differed across individual regions in the knee joint. Cartilage thinning alongside ages was identified, and the thinning pattern was consistent in the tibia while inconsistent in patellar and femoral between sexes. These findings provide a potential reference to detect cartilage anomaly.
Determinants of Frequent Attendance in Primary Care. A Systematic Review of Longitudinal Studies
Authors: Hajek André , Kretzler Benedikt , König Hans-Helmut 
Published: February 2021

Introduction: There is a lack of a systematic review synthesizing longitudinal studies investigating the determinants of frequent attendance in primary care. The goal of our systematic review was to fill this gap in knowledge.Methods: Three electronic databases (Medline, PsycINFO, and CINAHL) were searched. Longitudinal observational studies analyzing the predictors of frequent attendance in primary care were included. Data extraction covered methods, sample characteristics, and main findings. Selection of the studies, extracting the data and evaluation of study quality was performed by two reviewers. In the results section, the determinants of frequent attendance were presented based on the (extended) Andersen model.Results: In total, 11 longitudinal studies have been included in our systematic review. The majority of studies showed that frequent attendance was positively associated with the predisposing characteristics lower age, and unemployment. Moreover, it was mainly not associated with enabling resources. Most of the studies showed that need factors, and in particular worse self-rated health, lower physical functioning and physical illnesses were associated with an increased likelihood of frequent attendance. While most studies were of good quality, several of the included studies did not perform sensitivity analysis or described how they dealt with missing data.Discussion: Our systematic review showed that particularly lower age, unemployment and need factors are associated with the likelihood of becoming a frequent attender. Enabling resources are mainly not associated with the outcome measure. Future research should concentrate on the determinants of persistent frequent attendance due to the high economic burden associated with it.
Predicting Uncertain Multi-Dimensional Adulthood Outcomes From Childhood and Adolescent Data in People Referred to Autism Services
Authors: Forbes Gordon , Lord Catherine , Elias Rebecca , Pickles Andrew 
Published: February 2021

IntroductionAutism spectrum disorder is a highly heterogeneous diagnosis. When a child is referred to autism services or receives a diagnosis of autism spectrum disorder it is not known what their potential adult outcomes could be. We consider the challenge of making predictions of an individual child’s long-term multi-facetted adult outcome, focussing on which aspects are predictable and which are not.MethodsWe used data from 123 adults participating in the Autism Early Diagnosis Cohort. Participants were recruited from age 2 and followed up repeatedly through childhood and adolescence to adulthood. We predicted 14 adult outcome measures including cognitive, behavioral and well-being measures. Continuous outcomes were modeled using lasso regression and ordinal outcomes were modeled using proportional odds regression. Optimism corrected predictive performance was calculated using cross-validation or bootstrap. We also illustrated the prediction of an overall composite formed by weighting outcome measures by priorities elicited from parents.ResultsWe found good predictive performance from age 9 for verbal and non-verbal IQ, and daily living skills. Predictions for symptom severity, hyperactivity and irritability improved with inclusion of behavioral data collected in adolescence but remained modest. For other outcomes covering well-being, depression, and positive and negative affect we found no ability to predict adult outcomes at any age. Predictions of composites based on parental priorities differed in magnitude and precision depending on which parts of the adult outcome were given more weight.ConclusionVerbal and non-verbal IQ, and daily living skills can be predicted well from assessments made in childhood. For other adult outcomes, it is challenging to make meaningful predictions from assessments made in childhood and adolescence using the measures employed in this study. Future work should replicate and validate the present findings in different samples, investigate whether the availability of different measures in childhood and adolescence can improve predictions, and consider systematic differences in priorities.
Pathways From Family Violence to Adolescent Violence: Examining the Mediating Mechanisms
Authors: Li Spencer D. , Xiong Ruoshan , Liang Min , Zhang Xiaohua , Tang Wei 
Published: February 2021

PurposePast research has documented a significant relationship between family violence and adolescent violence. However, much is unknown about the processes through which this association occurs, especially in the non-Western cultural context. To address this gap, we propose an integrated model encompassing multiple pathways that connect family violence to adolescent violence. Specifically, this study investigates how family violence is related to adolescent violence through violent peer association, normative beliefs about violence, and negative emotions.MethodWe tested the model using the two-wave survey data collected from a probability sample of more than 1,100 adolescents residing in one of the largest metropolitan areas in China in 2015 to 2016.Results and ConclusionsThe results indicated that family violence predicted adolescent violence perpetration. Violent peer association, normative beliefs, and negative emotions, however, mediated much of the relationship between family violence and adolescent violence.
Adding Enzalutamide to First-Line Treatment for Metastatic Hormone-Sensitive Prostate Cancer: A Cost-Effectiveness Analysis
Authors: Zhang Peng-Fei , Xie Dan , Li Qiu 
Published: February 2021

Background: The aim of this study is to evaluate the pharmacoeconomic profile of adding enzalutamide to first-line treatment for metastatic, hormone-sensitive prostate cancer (mHSPC) from the US and Chinese payers' perspectives.Materials and Methods: A Markov model with three health states: progression-free survival (PFS), progressive disease (PD), and death, was constructed. All patients were assumed to enter the model in the PFS state and transit according to the transition structure. Efficacy data were derived from the ENZAMET trial and Weibull distribution curves were modeled to fit the survival curves. Costs in the model included cost of drugs, best-supportive care (BSC), follow-up, tests, and adverse events (AEs)-related treatments. The primary endpoint of the study was incremental cost-effectiveness ratio (ICER). In addition, the impact of several key parameters on the results of the cost-effectiveness analysis was tested with one-way sensitivity analyses and probabilistic sensitivity analyses.Results: Overall, ICERs were $430,933.95/QALY and $225,444.74/QALY of addition of enzalutamide to androgen deprivation therapy (ADT) vs. ADT from the US and Chinese payers' perspective, respectively. The most influential factors were the utility for the PFS state and the cost of enzalutamide. At the willingness-to-pay (WTP) thresholds of $100,000.00/QALY in the US and $28,988.40/QALY in China, the probability of adding enzalutamide to first-line treatment being a cost-effective option for mHSPC was 0%.Conclusions: Based on the data from the ENZAMET trial and the current price of enzalutamide, adding enzalutamide to first-line treatment is not cost-effective for patients with mHSPC from the US and Chinse payers' perspectives.
A 28 GHz Broadband Helical Inspired End-Fire Antenna and Its MIMO Configuration for 5G Pattern Diversity Applications
Authors: Zahra Hijab , Awan Wahaj Abbas , Ali Wael Abd Ellatif , Hussain Niamat , Abbas Syed Muzahir , Mukhopadhyay Subhas 
Published: February 2021

In this paper, an end-fire antenna for 28 GHz broadband communications is proposed with its multiple-input-multiple-output (MIMO) configuration for pattern diversity applications in 5G communication systems and the Internet of Things (IoT). The antenna comprises a simple geometrical structure inspired by a conventional planar helical antenna without utilizing any vias. The presented antenna is printed on both sides of a very thin high-frequency substrate (Rogers RO4003, εr = 3.38) with a thickness of 0.203 mm. Moreover, its MIMO configuration is characterized by reasonable gain, high isolation, good envelope correlation coefficient, broad bandwidth, and high diversity gain. To verify the performance of the proposed antenna, it was fabricated and verified by experimental measurements. Notably, the antenna offers a wide −10 dB measured impedance ranging from 26.25 GHz to 30.14 GHz, covering the frequency band allocated for 5G communication systems with a measured peak gain of 5.83 dB. Furthermore, a performance comparison with the state-of-the-art mm-wave end-fire antennas in terms of operational bandwidth, electrical size, and various MIMO performance parameters shows the worth of the proposed work.
INFLUENCE OF FINE-DISPERSED ADDITIVE FROM CONCRETE SCRAP ON STRUCTURE FORMATION OF PORTLANDCEMENT
Authors: Ahmed A. , Lesovik R. , Al'-Bo-Ali W. , Lesovik G. 
Published: February 2021

The object of the study is the effect of the introduction of a mineral additive (Ssp = 900 m2/kg) of the fraction (0.315–5 m) of the screening out of crushing concrete scrap into Portland cement for the production of various building products and structures. A fraction of concrete scrap of 0.315–5 mm is used in the work, since the X-ray phase analysis of various fractions of concrete scrap shows that these fractions have a rational content of non-hydrated particles of C3S and C2S. It is proved that the use of finely ground concrete scrap (Ssp = 900 m2/kg) as a mineral additive in Portland cement increaseINFLUENCE OF FINE-DISPERSED ADDITIVE FROM CONCRETE SCRAP
ON STRUCTURE FORMATION OF PORTLANDCEMENT
s the physical and mechanical properties of concrete. Comparative physical and mechanical indicators of the hardening of composite binders indicate that the most stable results with a uniform increase in strength is a composition with 5 % mineral additive, with an increase in strength from 2 to 7 days by 36 % and from 7 to 28 days by 46 %. It is found that the most rational are the compositions with 5 % and 10 % mineral additives providing an increase in the strength of the samples by 16% compared to the control composition. Due to the high dispersion, the mineral additive from concrete scrap acts as additional crystallization centers during the hydration of Portland cement, which leads to the creation of a skeleton coral-like structure, which additionally overgrows with submicroscopic crystals. With a specific surface area of 900 m2/kg, the best conditions are created for the formation of the primary frame and its further overgrowth with various crystalline calcium hydrates, which provide optimal density and strength.