bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISA KESIAPAN PENGUSAHA KOPI TERHADAP MINAT PEMANFAATAN MESIN ROASTING DENGAN MENGGUNAKAN MODEL UNIFIED THEORY OF ACCEPTANCE AND USE OF TECHNOLOGY (UTAUT)
Authors: Gartini Rini , Mauluddin Yusuf , Ikhwana Andri 
Published: July 2021

Kegiatan penelitian ini adalah menganalisis kesiapan pengusaha kopi terhadap minat pemanfaatan mesin roaster dengan merk North 500gr Coffee Roaster – TJ 068. Tujuan dari penelitian ini adalah terjelaskannya minat pemanfaatan mesin roaster oleh para pengusaha kopi dikabupaten garut. Mesin North 500gr Coffee Roaster – TJ 068 ini merupakan roaster kopi bertenaga listrik dengan kapasitas 500gr dibuat oleh North. Manfaat dari pemanfaatan mesin roaster ini membantu Pengusaha Kopi untuk melakukan pengolahan kopi dengan mesin yang standar. Model Unified Theory of Acceptance and Use of Technology yang dikembangkan oleh venkatesh, et al. (2003). Hasil yang diperoleh dari penelitian ini bahwa pengusaha kopi memberikan respon positif terhadap minat pemnafaatan mesin tersebut. Hasil temuan lain adalah perlunya pra kondisi yang harus dilakukian pengusaha apabila menggunakan mesin ini.
ANALISIS STRATEGI PEMASARAN USAHA MIE BASAH (Studi Kasus Di PD. LUGINA - Garut)
Authors: Hardiyansyah Andri , Ikhwana Andri , Kurniawati Rina 
Published: July 2021

Kegiatan penelitian yang dilakukan pada kesempatan kali ini adalah menganalisa stategi pemasaran di perusahaan mie basah di PD. Lugina. Tujuan dari penelitian ini adalah mengidentifikasi kekuatan, kelemahan, peluang dan ancaman perusahaan, kemudian menentukan strategi perusahaan berdasarkan faktor eksternal dan internal perusahaan setelah itu mendapatkan priorias strategi yang akan diterapkan. Dalam persaingan usaha suatu perusahaan dituntut untuk selalu mengembangkan strategi perusahaan agar dapat bertahan dan terus berkembang di tengah gencarnya persaingan usaha, oleh sebab itu perusahaan perlu mengembangkan suatu strategi yang tepat agar perusahaan dapat mempertahankan eksistensinya dan dapat memperbaiki kinerja perusahaan. Berdasarkan permasalahan tersebut akan dilakukan analisa internal dan eksternal menggunakan penggabungan metode BCG, matriks IFE&EFE serta Analisis SWOT. Kemudian dilakukan pembobotan menggunakan metode pendekatan AHP untuk mendapatkan prioritas strategi. Metode AHP merupakan pendekatan dasar untuk pengambilan keputusan. Dari hasil analisa diketahui bahwa prioritas strategi yang dapat digunakan PD. Lugina dalam menjalankan usahanya adalah dengan memperbaiki sistem manajemen.
STUDI KELAYAKAN PENINGKATAN KAPASITAS PERBAIKAN TABUNG GAS 3 KG DARI 25.000 MENJADI 30.000 PER BULAN DI PT. PATRA DINAMIKA
Authors: Dinika Asep Ihsan 
Published: July 2021

Penelitian ini bertujuan untuk menganalisis studi kelayakan peningkatkan kapasitas perbaikan tabung gas 3 kg dari 25.000 menjadi 30.000 perbulan, penambahan kapasitas ini dilakukan karena para pekerja dan mesin-mesin belum bekerja secara efektif dan efisien dikarenakan jumlah kuota yang diberikan oleh PERTAMINA kepada PT. Patra Dinamika sebanyak 25.000 perbulan sudah diselesaikan sebelum waktu yang ditentukan. Pengolahan data yang dilakukan yaitu mengenai harga pokok pabrik dan laporan laba rugi sehingga dapat dilakukan analisis dengan menggunakan metoda cash flow, payback period, net present value, internal rate of return dan break event point. Berdasarkan hasil tersebut diperoleh payback period selama 1 tahun 6 bulan, net present value sebesar Rp 2.175.890, internal rate of return sebesar 196% dan berdasarkan hasil perhitungan laporan laba rugi juga didapatkan keuntungan bersih Rp. 19.667.649 per bulan, sehingga dapat disimpulkan bahwa penambahan kapasitas perbaikan tabung gas 3 kg sebanyak 5.000 buah tabung per bulan ini layak.
PENETAPAN MODEL UPAH YANG AKAN DIBAYARKAN PADA KARYAWAN DI INDUSTRI RUMAHAN PRODUKSI JAKET
Authors: Hadianti Siti , Ikhwana Andri 
Published: July 2021

Tujuan dari penelitian ini adalah menetapkan model upah perangsang yang akan diterapkan pada perusahaan sebab ada ketidakadilan dalam memberikan insentif atau upah terhadap karyawan, hal ini merupakan hal yang melatar belakangi penelitian ini. Dalam upaya meningkatkan kinerja kerja karyawan, maka dilakukan penetapan model upah perangsang terhadap karyawan. Metode yang digunakan untuk memberikan upah perangsang kepada karyawan dengan menggunakan metode Premi 100%, Bedaux dan Emerson, dimana metode premi 100% memberikan keuntungan yang lebih besar. Hasil yang diperoleh dari ketiga metode tersebut yaitu harus ada perbaikan pemberian upah dengan menetapkan standar produksi sebanyak 26pcs/minggu atau menetapkan model upah premi 100% apabila dilihat dari sisi karyawan untuk meningkatkan keuntungan baik bagi karyawan maupun perusahaan.
ANALISIS ALIRAN AIR MELALUI BANGUNAN TALANG PADA DAERAH IRIGASI WALAHIR KECAMATAN BAYONGBONG KABUPATEN GARUT
Authors: Hakim Indra Lukman Nul , Permana Sulwan , Farida Ida 
Published: July 2021

Irigasi adalah kegiatan yang berhubungan dengan usaha mendapatkan air untuk sawah, ladang, perkebunan dan usaha-usaha pertanian lainnya. Oleh sebab itu perlu adanya keseimbangan antara kebutuhan dan ketersediaan air untuk memenuhi kebutuhan air Irigasi, maka debit yang tersedia harus cukup untuk di salurkan ke setiap saluran sampai kepetakan sawah. Oleh karena itu perlu di lakukan pengukuran debit air, kebutuhan air Irigasi, agar penyaluran air efektif dan efisien. Penelitian ini di lakukan di Daerah Irigasi Walahir, Kecamatan Bayongbong, Kabupaten Garut, penelitian ini di lakukan dengan cara mengambil data sekunder, data tersebut di kompilasikan dengan metode Hamon untuk menentukan evapotranspirasi, penyiapan lahan, penggunaan konsumtif, perlokasi, penggantian lapisan air, dan curah hujan efektif, dan menentukan pola tanamnya. Dengan menggunakan sistem pola tanam Padi-Padi-Palawij, dalam jangka waktu penyiapan lahan satu setengah bulan. Dari hasil analisis di dapatkan besarnya nilai debit kebutuhan air Irigasi maksimum untuk penyaluran air secara keseluruhan untuk Daerah Irigasi Walahir yang di ambil dari Sungai Cipandai melalui bangunan intake sebesar 181,35 lt/dtk, dengan luas area persawahan 60 Ha. Maka dari itu debit air yang mengalir di saat musim penghujan dari Bulan November sampai Bulan Mei sangat mencukupi untuk mengairi sampai ke petakan sawah terakhir, sedangkan hasil analisis terutama pada musim kemarau dari bulan Juni sampai bulan Oktober jumlah kebutuhan air lebih besar dari ketersediaan air. Maka dari itu antisipasinya dengan menggunakan sistem golongan atau sistem gilir pemberian air dengan jangka waktu satu minggu dua kali, supaya debit air yang tersedia di saat musim kemarau bisa mencukupi untuk kebutuhanya. Dengan kebutuhan air Irigasi untuk per hektarnya dari hasil analisis di dapat, kebutuhan air Irigasi 9 Ha dengan debit air 17,682 lt/dtk, kebutuhan air Irigasi 9 Ha dengan debit air 17,682 lt/dtk, kebutuhan air Irigasi 6 Ha dengan debit air 11,788 lt/dtk, kebutuhan air Irigasi 30 Ha dengan debit air 58,939 lt/dtk, dan kebutuhan air Irigasi 6 Ha dengan debit air 11,788l lt/dtk. Dan dari hasil analisis dimensi bangunan talang dengan debit rencana Q = 0,020135m3/dtk, dengan kecepatan standar aliran air V = 0,25 m/dtk, luas penampang basah A = 0,08054 m2, tinggi jagaan fb = 0,30 m, dan tinggi muka air yang baru 0,268 m, maka dimensi bangunan talang baru hasil analisis dengan debit rencana di dapat, lebar dasar saluran B = 0,30 m, dan tinggi total saluran H = 0,60 m.
Evaluasi Pondasi Bored Pile pada Proyek Kolam Ponds dengan Pile Driving Analyze Test
Authors: Permana Sulwan , Gunawan Anggi 
Published: July 2021

Dalam merencanakan suatu pondasi tiang, pertama perencana menghitung daya dukung pada pondasi yang menopang beban diatasnya. Pada pengujian pondasi proyek kolam Ponds PT. United Tractors PDA test dipilih untuk mengetahui kondisi pondasi tersebut. Penelitian ini bertujuan menganalisis daya dukung dan penurunan pondasi dibandingkan dengan result PDA serta menganalisis penyebab kerusakan pada tiang yang diuji. Metode penelitian yang digunakan adalah metode yang bersifat kualitatif lalu secara spesifik lebih diarahkan pada metode pendekatan studi kasus. Hasil dari penelitian ini yaitu perhitungan daya dukung pondasi tiang metode Schertmann & Nottingham Ø30 cm sebesar 39,62 ton, dan Ø40 cm sebesar 71,22 ton, sedangkan dengan metode Mayerhoff pondasi Ø30 cm sebesar 55,84 ton, dan Ø40 cm sebesar 92,49 ton. Hasil result PDA tiang bor titik 2 sebesar 89 ton, titik 10 sebesar 125 ton, titik 7 dan 8 tidak diketahui karena pondasi mengalami kerusakan, selisih daya dukung metode Schertmann & Nottingham dengan result PDA tiang bor titik 2 sebesar 19,97 %, dan tiang bor titik 10 sebesar 43 %, sedangkan metode Mayerhoff dengan result PDA titik 2 sebesar 19,97 %, dan tiang bor titik 10 sebesar -3,92 %, sehingga metode Mayerhoff disarankan untuk menganalisis pondasi tiang bored pile, hasil analisis penurunan pondasi tiang tunggal untuk pondasi Ø40 sebesar 0,055 m, sedangkan pondasi Ø30 sebesar 0,056 m, hasil penurunan pondasi PDA test untuk pondasi Ø40 masih dalam batas toleransi jika dibandingkan dengan hasil analisa 0,018 m ≤ 0,055 m (titik 2), dan 0,003 m ≤ 0,055 m (titik 10) sedangkan untuk pondasi titik 7 dan 8 tidak dapat dibandingkan karena data yang dibutuhkan tidak tersedia. Beberapa penyebab kerusakan tiang bor titik 7 dan 8 yaitu proses pekerjaan konstruksi, pengaruh air tanah, dan berat hammer, kemudian perbaikan untuk tiang bor yang rusak dengan cara metode chemical anchoor supaya tiang tidak mengalami deformasi.
Integrated Chromatin Accessibility and Transcriptome Landscapes of Doxorubicin-Resistant Breast Cancer Cells
Authors: Wang Xuelong , Yan Jizhou , Shen Baiyong , Wei Gang 
Published: July 2021

BackgroundDoxorubicin is one of the most effective chemotherapeutic drugs for breast cancer while its common drug resistance leads to poor patient prognosis and survival. Growing evidence indicate dynamically reorganized chromatin allows rapid access of the gene regulatory machinery to open genomic regions facilitating subsequent gene expression through direct transcription factor (TF) activation and regulatory element binding.MethodsTo better understand the regulatory network underlying doxorubicin resistance in breast cancer cells, we explored the systematic alterations of chromatin accessibility and gene expression by the assay for transposase-accessible chromatin using sequencing (ATAC-seq) in combination with RNA sequencing, followed by integrative analysis to identify potential regulators and their targets associated with differentially accessible regions (DARs) in doxorubicin-resistant MCF7 (MCF7-DR) cells.ResultsA total of 3,963 differentially expressed genes (DEGs) related to doxorubicin resistance were identified, including dramatically up-regulated MT1E, GSTP1, LDHB, significantly down-regulated TFF1, UBB, DSCAM-AS1, and histone-modifying enzyme coding genes HDAC2, EZH2, PRMT5, etc. By integrating with transcriptomic datasets, we identified 18,228 DARs in MCF7-DR cells compared to control, which were positively correlated with their nearest DEGs (r = 0.6). There were 11,686 increased chromatin-accessible regions, which were enriched in up-regulated genes related to diverse KEGG pathways, such as the cell cycle, regulation of actin cytoskeleton, signaling pathways of MAPK, PI3K/Akt and Hippo, which play essential roles in regulating cell apoptosis, proliferation, metabolism, and inflammatory responses. The 6,542 decreased chromatin-accessible regions were identified for the declined doxorubicin-associated biological processes, for instance, endocrine and insulin resistance, central carbon metabolism, signaling pathways of TGF-beta and P53. Combining data from TCGA, analyses of the DAR sequences associated with the DNA-binding motifs of significantly enriched TF families including AP-1, TEAD and FOX, indicated that the loss-function of FOXA1 might play a critical role in doxorubicin-resistant breast cancer cells (DOX-R BCCs).ConclusionThese data exhibit the non-genetic landscape of chromatin accessibility and transcript levels in the DOX-R BCCs, and provide clear insights and resources for the detection of critical TFs and potential cis-regulatory elements-based putative therapeutic targets.
A U-Shaped Relationship Between Selenium Concentrations and All-Cause or Cardiovascular Mortality in Patients With Hypertension
Authors: Tan Qiu-hong , Huang Yu-qing , Liu Xiao-cong , Liu Lin , Lo Kenneth , Chen Ji-yan , Feng Ying-qing 
Published: July 2021

Background: Given the antioxidant activity of selenium, it has been reported benefits for blood pressure control and hypertension prevention, but few studies have investigated the association between serum selenium with mortality in hypertensive population.Methods: All participants with hypertension aged ≥18 years at baseline were recruited from the National Health and Nutritional Examination Surveys (NHANES) 2003–2004, and followed for mortality through December 31, 2015. Subjects were categorized by quartiles of serum selenium (Q1: ≤124 μg/L, Q2: 125–135 μg/L, Q3: 136–147 μg/L, Q4: ≥148 μg/L). Multivariate Cox regression were implemented to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analysis and two-piecewise linear regression were used to evaluate the relationship of serum selenium with mortality. Survival curves were used to depict cause-specific mortalities.Results: A total of 929 participants (52.53% were male) were eligible for the current study with the average age of 63.10 ± 12.59 years. There were 307 deaths occurred including 56 cardiovascular death events during the mean follow-up time of 121.05 ± 40.85 months. A U-shaped association was observed between serum selenium and all-cause or cardiovascular mortality. In fully adjusted model, comparisons among quartiles revealed that risks of all-cause [HR (95%CI), 0.57 (0.39–0.81)] and cardiovascular death [HR (95%CI), 0.33 (0.13–0.86)] were lower in Q3. The nadir mortality of all-cause and cardiovascular was occurred at the serum selenium level of 136 μg/L and 130 μg/L, respectively.Conclusion: Serum selenium concentration showed a U-shaped association with all-cause and cardiovascular mortality.
Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart Failure
Authors: Kerp Helena , Hönes Georg Sebastian , Tolstik Elen , Hönes-Wendland Judith , Gassen Janina , Moeller Lars Christian , Lorenz Kristina , Führer Dagmar 
Published: July 2021

Purpose: Thyroid hormones (TH) play a central role for cardiac function. TH influence heart rate and cardiac contractility, and altered thyroid function is associated with increased cardiovascular morbidity and mortality. The precise role of TH in onset and progression of heart failure still requires clarification.Methods: Chronic left ventricular pressure overload was induced in mouse hearts by transverse aortic constriction (TAC). One week after TAC, alteration of TH status was induced and the impact on cardiac disease progression was studied longitudinally over 4 weeks in mice with hypo- or hyperthyroidism and was compared to euthyroid TAC controls. Serial assessment was performed for heart function (2D M-mode echocardiography), heart morphology (weight, fibrosis, and cardiomyocyte cross-sectional area), and molecular changes in heart tissues (TH target gene expression, apoptosis, and mTOR activation) at 2 and 4 weeks.Results: In diseased heart, subsequent TH restriction stopped progression of maladaptive cardiac hypertrophy and improved cardiac function. In contrast and compared to euthyroid TAC controls, increased TH availability after TAC propelled maladaptive cardiac growth and development of heart failure. This was accompanied by a rise in cardiomyocyte apoptosis and mTOR pathway activation.Conclusion: This study shows, for the first time, a protective effect of TH deprivation against progression of pathological cardiac hypertrophy and development of congestive heart failure in mice with left ventricular pressure overload. Whether this also applies to the human situation needs to be determined in clinical studies and would infer a critical re-thinking of management of TH status in patients with hypertensive heart disease.
Relationship Between Dams, Knickpoints and the Longitudinal Profile of the Upper Indus River
Authors: Zhou Liqin , Liu Weiming , Chen Xiaoqing , Wang Hao , Hu Xudong , Li Xuemei , Schwanghart Wolfgang 
Published: July 2021

Mass movements in mountainous areas are capable of damming rivers and can have a lasting effect on the river longitudinal profile. The long profile is commonly used to retrieve regional tectonic information, but how much dams may compromise geomorphometry-based tectonic analysis has not been systematically researched. In this study, we investigate the relationship between river dams and the longitudinal profile of the upper Indus River basin, based on interpretation and analysis of remote sensing imagery and digital elevation models (DEMs) and local field work. We identified 178 landslide, glacier and debris flow dams. Using TopoToolbox, we automatically extracted the river longitudinal profile from the 30 m SRTM DEM, determined the location of convex knickpoints and calculated the channel steepness index. One hundred and two knickpoints were detected with heights above 148 m, of which 55 were related to dams. There is good spatial correspondence between dams, convexities in the river longitudinal profile and relatively high steepness index. Different dam types have different impacts on the river profile; on the upper Indus, debris flow dams have a greater impact than landslide and glacier dams and can form knickpoints of up to 900 m. Therefore, dams may have a significant influence on the river longitudinal profile, knickpoints and steepness index, and should be considered when extracting information on regional tectonics using these indices.
The Influence of Previous Biology Lessons on Prospective Teachers’ Beliefs About Learning Biology
Authors: Schumacher Fabian , Basten Melanie , Großschedl Jörg , Klatthaar Moritz , Wilde Matthias 
Published: July 2021

Professional teaching competence is significantly influenced by beliefs about learning. Prospective teachers start their teacher training at university with quite persistent beliefs about learning processes. Beliefs about learning can be differentiated into two perspectives: beliefs about student learning and beliefs about one’s own learning. Theoretical considerations suggest that the latter influence beliefs about student learning and both perspectives are influenced by the way in which prospective teachers experienced their own lessons as pupils at school. We investigated how prospective biology teachers remembered their own biology lessons and how these experiences influenced their beliefs about learning regarding both perspectives. The sample consisted of 164 prospective biology teachers (Mage = 21.58 years, SDage = 2.5, 66.02% female) in Germany. Results of a simple mediation model indicate that previous experiences in biology lessons had an impact on both perspectives. Moreover, we found that the influence that previous lessons had on the beliefs about student learning was fully mediated by one’s beliefs about own learning processes. This suggests that experiences from one’s own schooling have an impact on how teachers view learning of their students. As implications for teacher training and future research, our findings suggest that both perspectives of beliefs need to be further taken into account and that an explicit focus on beliefs about teachers’ own learning is needed.
Analysis of IVF/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence on Cumulative Live Birth Rate
Authors: Zhong Chenyi , Gao Liusijie , Shu Li , Hou Zhen , Cai Lingbo , Huang Jie , Liu Jiayin , Mao Yundong 
Published: July 2021

ObjectiveTo study the influence of endometriosis activity on the pregnancy outcomes of patients with recurrent implantation failure (RIF) in in-vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI) cycles. The pregnancy outcomes were compared between RIF patients with endometriosis who received treatment at different occasions to explore the appropriate treatment plan for these patients and to optimize the pregnancy-support strategies.DesignAmbispective cohort study.MethodsA total of 330 patients with endometriosis were enrolled from 2008 to 2018 and included 1043 IVF/ICSI cycles. All patients were diagnosed with RIF after IVF/ICSI. Patients were assigned to three subtypes according to different control states of endometriosis, including the untreated, early-treatment, and late-treatment groups. The clinical pregnancy rate, live birth rate, and cumulative live birth rate of endometriosis patients with RIF were the main outcomes; additionally, the fertilization rate, available embryonic rate, and high-quality embryonic rate were also compared.ResultsThe early-treatment and late-treatment groups showed higher cumulative live birth rate than the untreated group (early-treated 43.6% vs. late-treated 46.3% vs. untreated 27.7%, P&lt;0.001), though patients in the two treatment groups had higher rates of adenomyosis and ovarian surgery. The two treatment group showed a better laboratory result than the untreated and especially, the early-treatment group. The untreated group (46.24%) had a lower IVF fertilization rate than the treated group (early-treated [64.40%] and late-treated [60.27%] (P&lt;0.001). In addition, the rates of available embryos and high-quality embryos in the early-treated group were much higher those that in the untreated group (90.30% vs. 85.20%, 76.50% vs. 64.47%). Kaplan–Meier curve showed that patients in the untreated group needed a mean of 23.126 months to achieve one live birth; whereas those in the treated group needed a comparatively shorter duration (early-treated: 18.479 ± 0.882 months and late-treated: 14.183 ± 1.102 months, respectively).ConclusionEndometriosis has a negative influence on IVF/ICSI outcome. The control of endometriosis activity can result in a higher cumulative live birth rate in patients. It is necessary for endometriosis patients to receive medical treatment to achieve a better prognosis especially for those with RIF.