bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family-Based Intervention Improves Maternal Psychological Well-being and Feeding Interaction of Preterm Infants
Authors: Meyer Elaine C. , Coll Cynthia T. Garcia , Lester Barry M. , Boukydis C. F. Zachariah , McDonough Susan M. , Oh William 
Published: December 2021

Objective. To determine the efficacy of an individualized, family-based intervention with preterm infants and their families.
Design. Randomized, repeated measures intervention outcome study.
Setting. Level III neonatal intensive care nursery.
Patients. Random sample of 34 preterm infants ≤1500 g and their families.
Interventions. Individualized, family-based intervention during the hospitalization and transition to home addressed problems identified by parents in four domains including: infant behavior and characteristics, family organization and functioning, caregiving environment, and home discharge and community resources.
Measurements and Main Results. Standardized questionnaires were administered at baseline and discharge to mothers, and predischarge bottle-feeding interactions were videotaped and coded by two blinded observers. Results were in favor of intervention (Int) versus control (Con) mothers (baseline; discharge) (P &lt; .05) on the Parental Stressor Scale Sights and Sounds subscale (Int 2.4 ± 1.0; 2.0 ± 0.8 vs Con 2.4 ± 0.9; 2.6 ± 0.8); Child's Appearance and Behavior subscale (Int 2.8 ± 1.0; 2.5 ± 1.1 vs Con 2.8 ± 0.8; 3.1 ± 0.6); and Total Stressor Score (Int 93.9 ± 36.6; 72.3 ± 41.8 vs Con 87.5 ± 26.7; 87.8 ± 26.2). On the Beck Depression Inventory, intervention mothers had significant decreases in depressive symptoms (39%; 11%) vs control mothers (31%; 44%). Maternal self-esteem in both groups improved over time. There were no significant group differences in family environment. During feeding interactions, intervention infants grimaced (P &lt; .001) and gagged (P &lt; .05) less than controls. Intervention mothers less frequently interrupted feedings (P &lt; .001); less frequently stimulated infant sucking (P &lt; .01); smiled more (P &lt; .001); vocalized more (P &lt; .01); demonstrated greater sensitivity to infant behavior (P &lt; .001), better quality of physical contact (P &lt; .001), and more positive affect (P &lt; .01).
Conclusions. Individualized, family-based intervention appears to reduce maternal stress and depression, and to enhance early mother-infant feeding interactions. Further research is needed to determine whether these short-term beneficial effects persist beyond the newborn period.
Tilt-Table Testing and Oral Metoprolol Therapy in Young Patients With Unexplained Syncope
Authors: O'Marcaigh Aengus S. , MacLellan-Tobert Susan C. , Porter Co-burn J. 
Published: December 2021

Objective. Tilt-table testing is useful for investigating unexplained syncope in pediatric patients. No data are available on the use of intravenous metoprolol during testing to identify children who might respond to subsequent oral β-adrenergic blockade or on the efficacy and safety of such oral therapy.
Design. To provide these data, we obtained follow-up information on 27 consecutive pediatric patients who had tilt-table testing for unexplained syncope.
Results. Nineteen patients (70%) had positive test results with or without isoproterenol infusion. All these patients had negative test results after intravenous infusion of metoprolol and subsequently were treated with oral metoprolol. Taking oral metoprolol therapy alone, 9 (47%) of the 19 patients were asymptomatic, 8 (42%) reported a decreased frequency of syncopal episodes, and 2 (11%) had unchanged or more frequent episodes. The mean dosage of metoprolol required to prevent symptoms was 1.5 mg/kg per day. Mild side effects were reported by 6 (32%) of the 19 patients. Six patients (32%) required additional medications.
Conclusions. We conclude that metoprolol is safe and effective for the treatment of most cases of neurocardiogenic syncope in children and that this response cannot be predicted accurately by the use of intravenous metoprolol during testing.
Geographic Mobility and Children's Emotional/Behavioral Adjustment and School Functioning
Authors: Simpson Gloria A. , Fowler Mary Glenn 
Published: December 2021

Objective. To evaluate the relationship of geographic mobility to children's emotional/behavioral adjustment and school functioning.
Design. Analysis of data from the 1988 National Health Interview Survey of Child Health in which multistage probability sampling was used to obtain data for nationally representative estimates of health and demographic characteristics of US children.
Participants. 10 362 US school-age children and their families.
Measurements. The 1988 National Health Interview Survey of Child Health includes data on health and demographic characteristics, emotional/behavioral variables, school functioning, and geographic mobility for 10 362 US school-age children. This study examined the relationship of children's geographic mobility to children's reported emotional problems, use of psychological help, scores on a Behavior Problem Index, repeating a grade in school, and being suspended or expelled from school.
Results. Twenty-four percent of children have never moved, 35% of children have moved once or twice, and 39% of children aged 6 to 17 years have moved three or more times in their lifetime. Using multiple logistic regression to control for important demographic variables, children who moved three or more times were 2.3 times more likely to have had emotional/behavioral problems, 2.2 times more likely to have received psychological help, 1.7 times more likely to have repeated a grade, and 1.9 times more likely to have been suspended or expelled from school compared with children who had never moved. Multiple regression was also used to analyze the impact of mobility in relation to scores on the Behavior Problem Index. Children who moved three or more times were 1.6 times more likely to be in the top tenth percentile of scores on the Behavior Problem Index compared with children who had never moved.
Conclusions. Children who move three or more times are at increased risk for emotional/behavioral and school problems. Thus, pediatricians, other health professionals, and educators should be alert to the potential educational and psychological problems among children from highly mobile families.
Geography of Pediatric Publication
Authors: Eldor Joseph 
Published: December 2021

The number of all medical publications in 1990 from online database EMBASE was related to physician population in 20 countries. United Kingdom ranked first, with Israel in second place.1
It was interesting to compare the country of the first author under the title of "Pediatrics" to the physician population of that country. For that the Excerpta Medica Abstract Journals on Silver-Platter CD-ROM of 1990 was searched. Excerpta Medica Abstract Journals encompasses 45 abstract journals published every year, covering a wide range of medical and biomedical subjects.
Usefulness of Specific IgM in the Diagnosis of Helicobacter pylori Infection
Authors: Blecker Uwe , Vandenplas Yvan 
Published: December 2021

Serologic enzyme-linked immunosorbent assay (ELISA) tests for the detection of Helicobacter pylon-specific IgG have been demonstrated to be comparable to invasive techniques.1 Therefore they have been proposed as a inexpensive and reliable screening method for the diagnosis of H pylori infection.2 To study further the value of last-generation serologic tests as a screening technique for H pylori infection, we evaluated a last-generation ELISA kit for the detection of H pylori-specific IgM.
During presurgical blood analysis venous blood was taken for last-generation ELISA tests for the detection of anti-H pylori IgG and IgM (Malakit Helicobacter pylori series, Biolab, Belgium) in 452 asymptomatic children (age 1 to 12 years, mean age 6.65 years) admitted for minor elective surgery.
Letter to the Editor
Authors: Hupert Jordan 
Published: December 2021

I wish to comment on the recent review/meta-analysis/guidelines article that discussed the management of young febrile children (0 to 36 months of age) in whom no source for the fever is discovered.1 Although I applaud the authors' attempt to bring order to a topic afloat in chaos, the article suffered from a number of significant deficiencies and methodological problems. Some of my concerns follow.
1. How was Medline searched? Specification of key words used in the search and number of articles obtained from the search were not provided.
Letter to the Editor
Authors: Baraff Larry J. , Bass James W. , Fleisher Gary R. , Klein Jerome O. , McCracken George H. , Powell Keith R. , Schriger David L. 
Published: December 2021

We are pleased at the interest the publication of the Practice Guideline created among the readers of Pediatrics and to have an opportunity to respond to the reader's comments.
Meta-analysis. We appreciate the thoughtful comments of Drs Lehmann and Andrews, Hupert, and Kokx regarding the methods of meta-analysis. The Medline search strategies were: (1) febrile (tw) or bacteremia (tw) and child (tw) or infant (tw) and not foreign language with subheadings of therapy, diagnosis, or epidemiology; (2) children (MESH) and explode fever (MESH) and not foreign language.
Konsistensi Putusan Hakim Terhadap Perkara Kerugian Lingkungan Hidup di Indonesia
Authors: Wahyuni Sri , Rahmawati Arum Nur , Kumala Dewi Cheryl Permata , Manika Widya Chrisna , Hermawan Sapto 
Published: December 2021

To ensure environmental sustainability, environmental management must be supported by the enforcement of environmental law through litigation process, whether on criminal, civil, or administrative aspects. (In Indonesia, there are numerous cases of environmental losses, as well as examples of environmental damage that have been attempted on the court of mandalawangi, natural kallista and sungailiat cases.) The purpose of this research is to find out the extent of court decisions’s consistencies on environmental cases Using normative legal research method, this research examined three court decisions form two different types of court, which are criminal court (Sungai Liat case) and civil court (Mandalawangi case and Kalistas case). It was found that these judicial decisions show inconsistencies. This condition may weaken the enforcement of environmental law in Indonesia. On the other hand, this difference in judgments may be apprehended as a new standpoint of environmental law in Indonesia. Keberlangsungan pengelolaan lingkungan hidup harus ditunjang dengan penegakan hukum lingkungan, baik melalui jalur peradilan maupun luar peradilan, baik yang bersifat perdata, pidana, maupun administrasi. Penelitian ini mengkaji tiga kasus lingkungan hidup yang diselesaikan melalui peradilan pidana dan perdata, yaitu Kasus Mandalawangi, Kasus Kallista Alam dan Kasus Sungailiat. Tujuan penelitian ini adalah untuk mengetahui problematika penegakan hukum lingkungan hidup di Indonesia, dan untuk mengetahui dampak dari konsistensi putusan hakim dalam perkara lingkungan di Indonesia yang berbeda-beda. Untuk mencapai tujuan tersebut, ketiga putusan hakim tersebut di atas dikaji dengan menggunakan metode penelitian hukum normatif. Hasil penelitin menunjukkan bahwa ketiga kasus tersebut diputuskan secara berbeda. Inkonsistensi tersebut dapat menjadi faktor pelemahan penegakan hukum lingkungan di Indonesia. Namun di samping itu dapat dimaknai sebagai suatu pandangan baru terhadap ketentuan lingkungan hidup di Indonesia.
SELECTION OF THE TECHNOLOGICAL PARAMETERS OF FERMENTATION OF HIGH-CONCENTRATION WORT WITH OSMOPHILIC YEAST RACES FOR OBTAINING BIOETHANOL
Authors: Kovalchuk S. , Mudrak T. 
Published: December 2021

Bioethanol production is a key issue that helps meet the growing demand for energy resources and ensure a sustainable economy. A promising direction is producing bioethanol by using the technology of fermentation of high-concentration wort obtained from the dry matter of grain raw materials. The purpose of this work is researching osmophilic races of distiller’s yeast under the conditions of fermentation of high-concentration wort at increased acidity. Selective breeding of a new strain of the yeast Saccharomyces cerevisiae DO-16 has allowed obtaining ethanol producers able to ferment grain wort with the dry matter concentration 24–34% at pH 6.0–3.0, with alcohol accumulation in the fermented wash up to 17% vol. It has been studied how the pH of wort affects the dynamics of yeast cell synthesis by the distiller’s yeast races Saccharomyces cerevisiae DO-11 and Saccharomyces cerevisiae DO-16. It has been established that at the pH values 2.5, 3.0, 3.5, and 4.0, the concentration of yeast cells in the race Saccharomyces cerevisiae DO-16 was higher by 2.6, 1.7, 1.5, and 1.4 times respectively, as compared with Saccharomyces cerevisiae DO-11. It has been found that culturing industrial yeast of these races at low pH values ​​will provide not only the required sterility of the substrate, but also a high content of yeast cells, which is 250–320 million/cm³. The chemical and technological parameters of the fermented wash obtained by using the yeast races Saccharomyces cerevisiae DO-11 and DO-16 at the wort concentration 20–34% DM have been studied. It has been found that under all research conditions, the yeast of the race Saccharomyces cerevisiae DO-16 synthesised more ethanol than the strain Saccharomyces cerevisiae DO-11 did. The use of a new high-productive strain of Saccharomyces cerevisiae DO-16 will allow fermenting wort with a high ethanol concentration in the wash. It will also reduce the consumption of heat expended on isolating alcohol from the wash and of water expended on cooling, and lessen the amount of post-alcohol stillage.
Characterization of women and youth smallholder agricultural entrepreneur’s in rural irrigation schemes in Vhembe district, South Africa
Authors: Mavhungu TJ , Nesamvuni AE , Tshikolomo KA , Raphulu T , Van Niekerk JA , Mpandeli NS , Nesamvuni AE 
Published: December 2021

The purpose of the study was to characterize irrigated smallholder agricultural enterprises (ISAEs) in selected areas of Vhembe District, Limpopo Province. The characterization focused on the geophysical environment and on participants in ISAEs. Precipitation was at most 460mmpa for villages along Madimbo Corridor and 701-1380mmpa for those along Mutale Valley, and temperatures were 38.1℃-44.0℃ (Madimbo) and 30.0℃-40.0℃ (Mutale). Groundwater supplemented surface water and was utilized more at Madimbo Corridor compared to Mutale Valley. The study area was characterized as semi-arid to sub-humid, hence technologies for efficient irrigation should be promoted. Participants in ISAEs were female (94.9%), and adult (52.72%) with low education levels (67.7% ≤ secondary education). The majority (88.65%) were not formally employed (54.61% self-employed, 34.04% full-time farmers). Participants experienced some level of poverty, 68.03 percent received low household incomes (R1001-R5000/month), 77 percent received social grants. Interestingly, the majority (65.31%) stayed in multiple-roomed houses, had cement brick walls, and corrugated iron roofs (54.42%), and all had electricity, a stove, and a fridge. Also, majority-owned radio (96.67%), DSTV (87.45%), vehicles (65.56%), and cellphones. Participants mostly provided adequate food supply (91.84%) with three meals/day (79.38%) except during hard times where 49.56 percent provided fewer meals mostly due to delayed readiness of farm produce. Strategies to empower ISAE participants to be more effective should consider their gender, age, education, and economic status estimated by income, asset ownership, and food security.
Unlocking the potential of value chains as climate change resilience strategies: can macadamia nuts (macadamia integrifolia) offer the gateway?
Authors: Bandason W , Parwada C , Musara JP , Nyamushamba GB , Kaseke T 
Published: December 2021

The consequences of climate change threaten existing agriculture systems across Zimbabwe. The researchers examined the possibility and potential for developing a smallholder farmer driven macadamia nuts value chain. Using the case of Chipinge district, Manicaland province, Zimbabwe, the study evaluated the potential of macadamia nut value chain functions as a climate change resilience strategy in Zimbabwe. Challenges faced by actors and positive developments made in incorporating smallholders into the macadamia nuts production sector were explored. The role of local markets and producers in the international trade in macadamia nuts were also examined, using a modified stakeholder analysis framework. Triangulation, a mixed methodology, was used to adequately capture the various quantitative and qualitative dimensions along the macadamia nuts value chain pillars. A sample of 220 farming units including Estates, A1 and A2 farmers was proportionately selected for the study. Primary data were collected from Key Informants through interviews and personal communications. Secondary data were collected from Agritex officers, buyers, and the Macadamia Association of Zimbabwe farmers’ records. The production-marketing interface for macadamia nuts is weakly coordinated in the study area as shown by the rudimentary production systems especially for the A1 and A2 farmers. Results show that the major missing links are the limited application of extension driven production enhancers and the limited visibility of farmers in more rewarding export markets. Production scales have, however, been increasing with more farmers allocating land towards the macadamia nuts trees. Decentralization of macadamia nuts markets and localized value addition needs to be done to realign domestic and export market prices.
Ikona niemieckiego Orgelbewegung – organy ośrodka Jugendhof Hassitz w Kłodzku-Jurandowie (Goszycach)
Authors: Prasał Andrzej 
Published: December 2021

Do pierwszych instrumentów powstałych na Śląsku w duchu Orgelbewegung należały organy Młodzieżowego Ośrodka Wypoczynkowo-Szkoleniowego w Kłodzku-Jurandowie. Ośrodek ten, założony z inicjatywy Richarda Poppego, stał się centrum odnowy ruchu śpiewaczego dla Niemiec wschodnich. Instrument nazwany Ver sacrum, czyli „Święta wiosna” miał upamiętniać i przypominać tych wszystkich, którzy poświęcili i oddali swoje życie za ojczyznę (zwłaszcza poległych w czasie I wojny światowej). Organy zostały wybudowane w 1929 r. przez firmę Sauer z Frankfurtu n. Odrą (opus 1400). Posiadały 27 głosów (w tym 21 realnych) i trakturę pneumatyczną z wiatrownicami typu kieszonkowego. Dyspozycję głosową opracował czołowy przedstawiciel ruchu Orgelbewegung dr Christhard Mahrenholz. O ile w warstwie brzmieniowej instrument nawiązywał do ideału organów z czasów Bacha, to jego mechanizm gry prezentował osiągnięcia XX wieku. Pod koniec 1945 r. organy zostały przekazane do kościoła parafialnego Trójcy Świętej w Strzelcach koło Kutna.
Structural and functional abnormalities of cell membranes in the end-stage chronic kidney disease
Authors: Ievlev E. N. , Kazakova I. A. , Sukhenko E. P. 
Published: December 2021

Background: Chronic kidney disease (CKD) is associated with abnormalities in all functions of the body systems including changes in intracellular processes. Assessment of erythrocyte electrophoretic mobility (EEM) in patients with CKD stage 5 on dialysis (5d) has becoming increasingly relevant, since this method characterizes the pathophysiological state of the patient and gives the possibility to modify treatment.Aim: To identify EEM characteristics in patients on programmed hemodialysis and their association with clinical and laboratory parameters.Materials and methods: We performed a cross-sectional observational study in 220 patients with confirmed CKD 5d. The average age of the patients was 56.5±1.4 years (26 to 85 years) and the duration of dialysis therapy was 3.7±0.4 years. The Kt/V urea adequacy index was 1.54±0.08. The control group included 60 healthy blood donors, comparable for their age and sex. EEM was assessed with Cyto-Expert kit (Axion Holding, Izhevsk, 2010) and the WT-Cell program (LLC Westtrade LTD, 2019). Statistical analysis was performed with BioStat 2019 software.Results: The patients on the programmed hemodialysis had lower values of oscillation amplitude (10.2±0.5 μm and 21.2±2.1 μm, p<0.001) and lower proportion of mobile red blood cells (69.5±1.8%, 89.7±9.9%, p<0.001), compared to the control group. Lower values of the oscillation amplitude were found in the age group of 25 to 44 years (9.0±1.0 μm, p<0.05). There was a weak positive correlation between age and amplitude of erythrocyte oscillation (R=0.20, p<0.05). There were differences in the oscillation amplitude values in the patients with various dialysis experience: 1 to 2 years, 11.3±0.8 μm, 2 to 5 years, 9.9±0.7 μm, 6 to 10 years, 9.4±1.3 μm, and over 11 years, 7.4±0.9 μm (p<0.05). The duration of dialysis therapy demonstrated a weak negative correlation with the amplitude of erythrocyte oscillation (R=-0.24, p<0.01). The erythrocyte oscillation amplitude was associated with systolic blood pressure before hemodialysis procedure (R=0.34, p<0.05) and with pulse pressure before hemodialysis (R=0.37, p<0.05). The proportion of mobile erythrocytes correlated with parathyroid hormone level (R=0.32, p<0.05).Conclusion: EEM in the patients receiving programmed hemodialysis have their specific characteristics related to a significant decrease in the oscillation amplitude proportional to the effective cell charge and lower proportions of mobile erythrocytes compared to those in the healthy control. The erythrocyte oscillation amplitude is negatively correlated with age and duration of dialysis therapy and is associated with blood pressure parameters and mineral bone indices.
Cryotherapy of the distal limbs: an effective treatment for equine laminitis following onset of lameness?
Authors: Ryde Lucy 
Published: December 2021

PICO question
In horses with acute laminitis, does cryotherapy of the distal limbs applied after onset of clinical signs lead to improved clinical outcomes compared to horses treated without cryotherapy?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Four papers were critically appraised; there were three randomised, controlled trials, and one retrospective cohort study.
Strength of evidence
Weak
Outcomes reported
There were reduced histological changes and lamellar injury in limbs treated with cryotherapy in the randomised controlled trials and reduced clinical severity of laminitis in horses treated with cryotherapy in the retrospective cohort study.
Conclusion
In horses with acute laminitis there is weak evidence to suggest that cryotherapy of the distal limbs is an effective treatment option when applied following onset of clinical signs. Further randomised, controlled trials should be performed to assess clinical outcomes of cryotherapy in order to draw definitive conclusions.

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.