bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isoflurane Suppresses Proliferation, Migration, and Invasion and Facilitates Apoptosis in Colorectal Cancer Cells Through Targeting miR-216
Authors: Cai Zhe , Suo Liangyuan , Huang Zeqing 
Published: August 2021

Objective: Surgery is the first line treatment of colorectal cancer (CRC). Anesthetic isoflurane may improve outcomes of cancer surgery. Herein, we investigated the effects of isoflurane on malignant behaviors of CRC cells and its underlying therapeutic target.Methods: SW620 and HCT116 CRC cells were exposed to a series of concentrations of isoflurane. CCK-8 assay was utilized for determination of the optimal concentration of isoflurane. Under treatment with isoflurane, proliferation, migration, and invasion were separately assessed via clone formation and transwell assays. Apoptotic levels were observed via flow cytometry and expression of Bax, Bcl-2, and Caspase3 proteins was quantified through western blot. MiR-216 expression was detected in isoflurane-induced SW620 and HCT116 cells by RT-qPCR. Following transfection with miR-216 mimic, malignant biological behaviors were examined in isoflurane-treated SW620 and HCT116 cells.Results: 40 μM isoflurane distinctly restrained proliferative, migrated, and invasive capacities and elevated apoptotic levels in SW620 and HCT116 cells. Up-regulation of miR-216 was found in CRC cells. Its expression was suppressed by isoflurane. MiR-216 mimic ameliorated the reduction in proliferation, migration, and invasion and the increase in apoptosis for 40 μM isoflurane-induced SW620 and HCT116 cells.Conclusion: Isoflurane, a promising drug of CRC, may suppress malignant biological behaviors of tumor cells. Furthermore, miR-216 is an underlying target of isoflurane. Thus, isoflurane could be adopted for CRC treatment.
Classifying Ruptured Middle Cerebral Artery Aneurysms With a Machine Learning Based, Radiomics-Morphological Model: A Multicentral Study
Authors: Zhu Dongqin , Chen Yongchun , Zheng Kuikui , Chen Chao , Li Qiong , Zhou Jiafeng , Jia Xiufen , Xia Nengzhi , Wang Hao , Lin Boli , Ni Yifei , Pang Peipei , Yang Yunjun 
Published: August 2021

ObjectiveRadiomics and morphological features were associated with aneurysms rupture. However, the multicentral study of their predictive power for specific-located aneurysms rupture is rare. We aimed to determine robust radiomics features related to middle cerebral artery (MCA) aneurysms rupture and evaluate the additional value of combining morphological and radiomics features in the classification of ruptured MCA aneurysms.MethodsA total of 632 patients with 668 MCA aneurysms (423 ruptured aneurysms) from five hospitals were included. Radiomics and morphological features of aneurysms were extracted on computed tomography angiography images. The model was developed using a training dataset (407 patients) and validated with the internal (152 patients) and external validation (73 patients) datasets. The support vector machine method was applied for model construction. Optimal radiomics, morphological, and clinical features were used to develop the radiomics model (R-model), morphological model (M-model), radiomics-morphological model (RM-model), clinical-morphological model (CM-model), and clinical-radiomics-morphological model (CRM-model), respectively. A comprehensive nomogram integrating clinical, morphological, and radiomics predictors was generated.ResultsWe found seven radiomics features and four morphological predictors of MCA aneurysms rupture. The R-model obtained an area under the receiver operating curve (AUC) of 0.822 (95% CI, 0.776, 0.867), 0.817 (95% CI, 0.744, 0.890), and 0.691 (95% CI, 0.567, 0.816) in the training, temporal validation, and external validation datasets, respectively. The RM-model showed an AUC of 0.848 (95% CI, 0.810, 0.885), 0.865 (95% CI, 0.807, 0.924), and 0.721 (95% CI, 0.601, 0.841) in the three datasets. The CRM-model obtained an AUC of 0.856 (95% CI, 0.820, 0.892), 0.882 (95% CI, 0.828, 0.936), and 0.738 (95% CI, 0.618, 0.857) in the three datasets. The CRM-model and RM-model outperformed the CM-model and M-model in the internal datasets (p &lt; 0.05), respectively. But these differences were not statistically significant in the external dataset. Decision curve analysis indicated that the CRM-model obtained the highest net benefit for most of the threshold probabilities.ConclusionRobust radiomics features were determined related to MCA aneurysm rupture. The RM-model exhibited good ability in classifying ruptured MCA aneurysms. Integrating radiomics features into conventional models might provide additional value in ruptured MCA aneurysms classification.
Why Does Child Mortality Decrease With Age? Modeling the Age-Associated Decrease in Mortality Rate Using WHO Metadata From 25 Countries
Authors: Dolejs Josef , Homolková Helena 
Published: August 2021

Background: Our previous study analyzed the age trajectory of mortality (ATM) in 14 European countries, while this study aimed at investigating ATM in other continents and in countries with a higher level of mortality. Data from 11 Non-European countries were used.Methods: The number of deaths was extracted from the WHO mortality database. The Halley method was used to calculate the mortality rates in all possible calendar years and all countries combined. This method enables us to combine more countries and more calendar years in one hypothetical population.Results: The age trajectory of total mortality (ATTM) and also ATM due to specific groups of diseases were very similar in the 11 non-European countries and in the 14 European countries. The level of mortality did not affect the main results found in European countries. The inverse proportion was valid for ATTM in non-European countries with two exceptions.Slower or no mortality decrease with age was detected in the first year of life, while the inverse proportion model was valid for the age range (1, 10) years in most of the main chapters of ICD10.Conclusions: The decrease in child mortality with age may be explained as the result of the depletion of individuals with congenital impairment. The majority of deaths up to the age of 10 years were related to congenital impairments, and the decrease in child mortality rate with age was a demonstration of population heterogeneity. The congenital impairments were latent and may cause death even if no congenital impairment was detected.
Defense Mechanism Functioning in Patients With Breast Cancer: Using the Defense Mechanism Rating Scale
Authors: Saab Marwa , Hartmann Matias , Han Xue 
Published: August 2021

Background: Breast cancer (BC) is one of the highest incidence rates in Lebanon. Previous studies had focused scarcely on the unconscious protective shield of patients with BC or BC survivors against cancer, while only some studies had focused on the relationship between defense mechanisms (DMs) and high adaptation with the disease process and progress. Therefore, this study aimed to investigate the reaction of inpatients with BC toward the disease by measuring DMs in the Lebanon context.Methods: Seventy inpatients with BC were recruited randomly from six hospitals. Their DMs were measured using the Defense Mechanism Rating Scale. Moreover, the Relationship Anecdotes Paradigm (RAP) was used with three recent life vignettes of initial diagnosis, family, and daily life. The data were analyzed using repeated measure ANOVA, Wilcoxon rank-sum test, and Spearman's rank.Results: Patients with stage 2 BC used more high-adaptive defense levels than patients with stage 4 BC who used more minor image distorting defense levels. Moreover, patients with stage 2 BC used more self-observation and undoing, while patients with stage 4 BC used more devaluation.Conclusion: The severity of BC, the age of carriers, and the social status may lead to higher use of DMs, at the level of the individual defense and the hierarchal or the tripartite levels.
Internal Consistency and Structural Validity of the Norwegian Translation of the Ten-Item Personality Inventory
Authors: Thørrisen Mikkel Magnus , Sadeghi Talieh , Wiers-Jenssen Jannecke 
Published: August 2021

Background: The Ten-Item Personality Inventory (TIPI) is a validated brief instrument measuring the five-factor model (FFM) personality dimensions, developed for instances where more comprehensive FFM instruments are impractical to use. The TIPI has been translated into several languages, but psychometric properties of the Norwegian version (N-TIPI) have not been systematically explored.Objectives: This study aimed to explore the psychometric properties of the N-TIPI, in terms of internal consistency and structural validity.Methods: In a cross-sectional study, responses on the N-TIPI were collected from 5,009 Norwegian master graduates. Descriptive statistics for the subscales and correlations between subscales were calculated. Internal consistency was assessed with inter-item correlations, Cronbach’s α and Spearman-Brown coefficients. Structural validity was explored with principal component analysis, parallel analysis, and visual scree plot inspection. Results for the N-TIPI were compared with those previously reported for the original TIPI as well as the German, French, Spanish, and Portuguese versions.Results: Compared with the original and non-English versions of TIPI, results for N-TIPI showed comparable subscale rank order of means, standard deviations, and pattern of correlations between subscales, as well as inter-item correlations and Cronbach’s α. The 10 N-TIPI items were adequately reduced to five components, theoretically corresponding with the FFM personality domains.Conclusion: The N-TIPI demonstrated acceptable internal consistency and satisfactory structural validity. Although further research is warranted, the instrument stands out as feasible when it is essential to minimize participants’ response burden in studies that aim to explore personality as one among several concepts or utilize personality traits as covariates.
Effect of Carbon Black Nanoparticle on Neonatal Lymphoid Tissues Depending on the Gestational Period of Exposure in Mice
Authors: Onoda Atsuto , Okamoto Saki , Shimizu Ryuhei , El-Sayed Yasser S. , Watanabe Shiho , Ogawa Shuhei , Abe Ryo , Kamimura Masao , Soga Kohei , Tachibana Ken , Takeda Ken , Umezawa Masakazu 
Published: August 2021

Introduction:Particulate air pollution, containing nanoparticles, enhances the risk of pediatric allergic diseases that is potentially associated with disruption of neonatal immune system. Previous studies have revealed that maternal exposure to carbon black nanoparticles (CB-NP) disturbs the development of the lymphoid tissues in newborns. Interestingly, the CB-NP-induced immune profiles were observed to be different depending on the gestational period of exposure. It is important to identify the critical exposure period to prevent toxic effects of nanoparticles on the development of the immune system. Therefore, the present study was aimed to investigate the effect of CB-NP on the development of neonatal lymphoid tissues in mice, depending on the gestational period of exposure.Methods:Pregnant ICR mice were treated with a suspension of CB-NP (95 μg/kg body weight) by intranasal instillation; the suspension was administered twice during each gestational period as follows: the pre-implantation period (gestational days 4 and 5), organogenesis period (gestational days 8 and 9), and fetal developmental period (gestational days 15 and 16). The spleen and thymus were collected from offspring mice at 1, 3, and 5-days post-partum. Splenocyte and thymocyte phenotypes were examined by flow cytometry. Gene expression in the spleen was examined by quantitative reverse transcription-polymerase chain reaction.Results:The numbers of total splenocytes and splenic CD3−B220−phenotype (non-T/non-B lymphocytes) in offspring on postnatal day 5 were significantly increased after exposure to CB-NP during the organogenesis period compared with other gestational periods of exposure and control (no exposure). In contrast, expression levels of mRNA associated with chemotaxis and differentiation of immune cells in the spleen were not affected by CB-NP exposure during any gestational period.Conclusion:The organogenesis period was the most susceptible period to CB-NP exposure with respect to lymphoid tissue development. Moreover, the findings of the present and previous studies suggested that long-term exposure to CB-NP across multiple gestational periods including the organogenesis period, rather than acute exposure only organogenesis period, may more severely affect the development of the immune system.
ОСОБЛИВОСТІ ЛІКУВАННЯ ІНТРААРТИКУЛЯРНИХ ФУНКЦІОНАЛЬНИХ РОЗЛАДІВ СКРОНЕВО-НИЖНЬОЩЕЛЕПНОГО СУГЛОБА З ВИКОРИСТАННЯМ ОКЛЮЗІЙНИХ КАПОВИХ КОНСТРУКЦІЙ
Authors: Клочан С. М. , Біда В. І. 
Published: August 2021

Найпоширенішою групою інтраартикулярних функціональних розладів скронево-нижньощелепного суглоба (СНЩС) є біомеханічні розлади комплексу «суглобова голівка – суглобовий диск» із переднім зміщенням сугло-бового диска. Клінічні діагностичні критерії дозволяють визначити факт наявності патології, натомість, важливим в діагностиці для лікаря є встановлення його причини з метою надання максимально ефективної лі-кувальної допомоги. Ортопедичне лікування з використанням оклюзійних капових конструкцій (оклюзійна сплінт-терапія) є важливою стоматологічною складовою в лікуванні інтраартикулярних розладів СНЩС.
Вибір оклюзійної капової конструкції, її лікувальний ефект залежить від патобіомеханічних характеристик функціональних розладів, стадії та вираженості патологічного процесу, клінічної симптоматики та функціо-нальних ускладнень.Мета. Дати узагальнену характеристику основних оклюзійних капових конструкцій для лікування інтраа-ртикулярних функціональних розладів СНЩС.Результати. Конструктивні особливості оклюзійних кап залежать від їх функціонального призначення. При інтракапсулярних функціональних розладах СНЩС застосовують релаксаційно-стабілізуючі оклюзійні ка-пи для стабілізації положення нижньої щелепи та нормалізації роботи жувальних м’язів, репозиційні капи за-стосовують для встановлення нижньої щелепи в лікувальне положення із нормалізацією суглобових елементів «голівка - диск - ямка». Незнімні оклюзійні накладки, виготовлені із бісакрилового матеріалу дозволяють пос-тійно зберігати позицію нижньої щелепи з оптимізацією внутрішньо-суглобових взаємовідношень та усунення надмірних травматичних навантажень на СНЩС.Висновки. Застосування оклюзійних капових конструкцій (сплінт-терапії) для усунення біомеханічних проявів інтракапсулярних розладів СНЩС, таких як зміщення суглобового диска, є важливою складовою ліку-вальної тактики та показало позитивну динаміку у зниженні клінічних проявів, в тому числі запального процесу та больового синдрому.
Kelaikan Penyelenggaraan Makanan pada Rumah Makan berdasarkan Pemeriksaan Fisik dan Laboratorium
Authors: Dwi Alristina Arie , Rossa Kurnia Ethasari  , Dewinta Hayudanti  
Published: August 2021

Various kinds of health problems that commonly occur in restaurants include food poisoning and diarrhea outbreaks caused by negligence in the process of organizing food. Therefore, the fulfillment of food hygiene and sanitation is needed in testing the feasibility of organizing food according to the provisions stipulated based on Permenkes RI No. 1096 / Menkes / PER / VI / 2011 concerning Jasaboga Sanitation Hygiene. This research was conducted to assess the feasibility of serving food in a restaurant. The study was conducted descriptively through an experimental and observational design. The instrument used was a physical test by interview and observation as well as laboratory test of food samples and tableware. Physical test includes requirements for food hygiene and sanitation consisting of building elements, sanitation facilities, personnel / handlers, equipment and food. The results of the feasibility assessment at the Jibsteak Restaurant were 70.08%, where the eligibility standard for the A3 class restaurants was 74%. This means that the restaurant has not met the feasibility of physically organizing food. Likewise, the results of laboratory tests on eating utensils and food were still found to be contaminated with E. coli bacteria. This means that the restaurant also has not met the eligibility standards by laboratory tests which require the E. coli germ count 0 / gr of food samples.
ABSTRAK
Berbagai macam masalah kesehatan yang biasa terjadi di rumah makan diantaranya adalah keracunan makanan dan wabah penyakit diare yang diakibatkan karena kelalaian dalam proses penyelenggaraan makanan. Oleh karena itu terpenuhinya higiene dan sanitasi makanan sangat diperlukan dalam uji kelaikan penyelenggaraan makanan sesuai ketentuan yang diatur dalam Permenkes RI No. 1096/Menkes/PER/VI/2011 tentang Higiene Sanitasi Jasaboga. Penelitian ini bertujuan menilai kelaikan penyelenggaraan makanan di rumah makan. Metode: Penelitian dilakukan secara deskriptif melalui pendekatan analisa kualitatif. Instrumen yang digunakan adalah pemeriksaan fisik dengan wawancara dan observasi serta pemeriksaan laboratorium terhadap sampel makanan dan peralatan makan. Hasil: Pemeriksaan fisik meliputi persyaratan higiene dan sanitasi makanan yang terdiri atas unsur bangunan, fasilitas sanitasi, ketenagaan/penjamah, peralatan dan makanan. Hasil penilaian kelaikan pada Rumah Makan Jibsteak sebesar 70,08% dimana standar kelaikan untuk rumah makan golongan A3 sebesar 74%. Hal ini berarti rumah makan tersebut belum memenuhi kelaikan penyelenggaraan makanan secara fisik. Begitu pula hasil pemeriksaan laboratorium pada peralatan makan dan makanan masih ditemukan kontaminasi bakteri E. coli. Hal ini berarti rumah makan tersebut juga belum memenuhi standar kelaikan secara pemeriksaan laboratorium yang mensyaratkan angka kuman E. coli 0/gr sampel makanan.
A STUDI FENOMENOLOGIS : KEKERASAN DALAM PACARAN PADA REMAJA DI KECAMATAN X KABUPATEN SEMARANG
Authors: Pranoto Heni , Masruroh  
Published: August 2021

Dating violence is one of the crucial issues at a global level facing adolescents and young adults. Dating violence includes physical, emotional, verbal, social, and sexual aggression behaviors aimed at controlling and hurting a partner. The cause of the high rate of dating violence is that many women do not understand the forms of physical, psychological and sexual violence in love.This study aims to find the description of dating violence on youth. This was a qualitative study with phenomenological approach. Respondents were 5 youth aged 18-21 years and had been dating. The data sampling used snowball sampling technique, and data analysis used the kualitatif method. The results of this study indicate that the types of dating violence include jealousy, interrogation, threats, being called by unwelcome term, promised to call, forced kissing, touching, sexual intercourse, slapped and pinched. From these results, it can be concluded that violence in dating is still common, whether it is emotional violence, sexual violence, or physical violence. The youth are expected to have good communication with their partners and have more assertiveness in taking attitudes, dare to refuse and ask for help if they experience acts of violence.
Guías de recuperación acelerada en cirugía ginecológica
Authors: Godínez Lisbeth , Samayoa Carmen , Rodas Luisa , Alvarado Sebastián , Estrada Adriana , Hernández Nancy , Knoepffler Adriana , Blanco Angélica , Rivas Diego , González Carmen 
Published: August 2021

Recuperación acelerada después de cirugía (Enhanced Recovery After Surgery : ERAS), ha sido creada para todas las disciplinas quirúrgicas y de anestesia, con el objetivo de mejorar la atención del paciente y ofrecer una recuperación más rápida, cómoda, con menos complicaciones y con el fin de un regreso rápido a sus actividades diarias. Tomando en cuenta la importancia de llevar a cabo el protocolo ERAS, se presenta el siguiente caso clínico manejado en el Hospital de Gineco-Obstetricia del Instituto Guatemalteco de Seguridad Social (IGSS), de una paciente femenina quien fue sometida a histerectomía abdominal total. Se analizará como el caso fue manejado conforme a las guías ERAS con el objetivo de una recuperación acelerada y óptima de la paciente.
Effect of anti-tuberculosis treatment on weight of tuberculous patients following up in Gulab Devi Hospital, Lahore
Authors: Rahman Usman Ali , Razzaq Anjum , Iftikhar Muhammad Adil , Changazi Shabbar Hussain , Bhatti Samiullah , Ahmad Qamar Ashfaq 
Published: August 2021

Background: Tuberculosis is the most prevalent disease in Pakistan. Multiple studies have been conducted on disease pattern and anti-tuberculosis therapy however; there is sparse literature of anti-tuberculosis therapy on weight gain of patients. The objective of this study was to measure the effect of anti-tuberculosis treatment on weight of the patient.
Subjects and methods: It was a cross sectional study conducted for a period of 1 year at Pulmonology and Surgical OPD of Gulab Devi Chest Hospital Lahore. Interview of 400 patients were recorded and there record of weight and height was collected at start of the treatment, at 02 months and at 6 months of treatment.
Results: Mean weight change in 400 patients were 3.06 ± 3.97 Kg. Out of 400 patients 310 had weight gain, 50 patients had weight loss and in 40 patients weight remain unchanged. Mean weight gain in 310 patients was 4.53 ± 2.95 kg with maximum weight gain of 16 Kg. Mean weight loss in 50 patients was 3.67 ± 2.63 Kg with maximum weight loss of 14 Kg.
Conclusion: A significant weight gain was seen in patients undergoing anti tuberculosis treatment. Younger age group, treatment completion and drug compliance had positive association with weight gain of the patient. Diabetes mellitus was the only co morbidity found to have negative association with weight gain of the patient.
Neonatal outcomes of birth asphyxia in tertiary care hospital of low-income country
Authors: Siddiqui Muhammad Asif , Masood Sehrish , Butt Tayyaba Khawar , Tariq Shahla 
Published: August 2021

Background: Pakistan has highest neonatal mortality in the region and birth asphyxia is one of the main preventable contributors to this. Objective of this study is to determine the frequency of different neonatal outcomes in neonates with birth asphyxia.
Subjects & Methods: It was descriptive case series study conducted in Department of Pediatrics Medicine, Services Hospital, Lahore in 6 months period during 6th Dec 2016 to 5th June 2017. 150 cases were included using non probability, consecutive sampling with 95% confidence level, 6% margin of error taking an expected percentage of neonate mortality as 15%. Data was analyzed with SPSS version 23. Categorical variables i.e., gender and neonatal outcomes in terms of neonatal mortality, discharge and neurological complications were expressed by frequency and percentage. Post stratification chi square test was applied. A p-value of <0.05 was taken as significant.
Results: The mean age of neonates was 3.09±0.8 hours. Outcomes of these neonates was seen in terms of mortality, discharge and neurological problems. Out of total 150 patients, 51 (34%) neonates expired and 99 (66%) neonates were survived. And neonates 69 (46%) neonates were diagnosed with neurological complications.
Conclusion: We found, birth asphyxia has significant association with neonatal mortality and neurological complications. Prevention of birth asphyxia with appropriate resuscitation at birth may be helpful in reduction of morbidity and mortality due to birth asphyxia.Neonates