bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract TP400: Evoked Functional Cerebral Hemodynamic and Metabolic Responses in Premature Infants with and without Germinal Matrix Hemorrhage
Authors: Lin Pei-Yi , Cheng Fang-Yu , Hagan Katherine , Sheldon Yvonne , Grant Ellen P. , Franceschini Maria Angela 
Published: June 2021

We have created an innovative new method which uses frequency domain near-infrared spectroscopy (FDNIRS) in
combination with diffuse correlation spectroscopy (DCS) to quantitatively measure cerebral blood flow (CBF) and oxygen

metabolism (CMRO
2
) right at the infant’s bedside. We have previously found CBF and CMRO
2
are more sensitive indicators

of cerebral pathophysiology than hemoglobin saturation (SO
2
). Using FDNIRS-DCS, we had found extremely premature

infants with germinal matrix hemorrhage (GMH) have lower cerebral blood flow (CBF) and oxygen metabolism

(CMRO
2
)

than gestational age-matched controls. For this study, we investigate whether GMH, along with age and

hematocrit levels, affect evoked hemodynamic responses. The study protocol was reviewed and approved by the
Institutional Review Board for Partners Healthcare. We enrolled eleven premature infants in the neonatal intensive care
unit at Brigham and Women’s Hospital. Three of them had Grade I GMH diagnosed by head ultrasound on the first three
days of life. We integrated continuous wave NIRS (CWNIRS) with DCS to measure dynamic changes of cerebral hemoglobin
concentrations (HbO) and CBF in response to somatosensory stimuli. For each measurement, we measured differential
path length factors and baseline cerebral hemoglobin concentrations with FDNIRS to quantify relative hemodynamic and

metabolic changes (rHbO, rCBF and rCMRO
2
) in response to tactile stimulation. We observed a faster response time to

reach peak value in preterm infants with increasing postmenstrual age (PMA), demonstrating the response matures with
age to become more adult-like (r=-0.513, p=0.007). In addition, infants measured at older PMA tend to have responses

with a larger undershoot in HbO. However, the HbO undershoot did not translate into an undershoot in CMRO
2
. The HbO

undershoot may therefore be a consequence of low hematocrit during the first two months of life which results in
insufficient oxygen supply and leads to abnormally large oxygen extraction from the blood. We found the activation
pattern of Grade I GMH infants did not differ from premature infants without hemorrhage. The study is ongoing and shows
our method is suitable to measure cerebral maturation in neonates with hemorrhage.
Naming for Kin during World War I: Baby Names as Markers for War
Authors: Todd Nicolas , Coulmont Baptiste 
Published: June 2021

Abstract
The choice of baby names can reveal how rapidly individuals adapt to new circumstances. A French genealogy database of 5.5 million individuals born between 1905 and 1925 permits an analysis of name transmission from father to son/daughter and uncle to nephew/niece as a reaction to the family disruptions caused by the exigencies of World War I. Immediately following mobilization, the rate of paternal name transmission increased by about 50 percent for both males and females, enhanced by a father’s level of risk as a soldier. Transmission of an uncle’s name increased following his death regardless of whether he died at war, though the phenomenon was significantly more sustained if he did so.
The Efficiency of (videolaryngo) stroboscopy in Detecting T1a Glottic Carcinoma and Its Preliminary Stages
Authors: Heyduck Adrienne , Brosch Sibylle , Pickhard Anja , Hoffmann Thomas K. , Reiter Rudolf 
Published: June 2021

Objective: The efficiency of laryngovideostroboscopy (LVS) in detecting premalignancies of the vocal fold and early glottic cancer was determined in a prospective monocentric study. In addition, the recovery rate of the mucosal membrane on the vocal fold after surgical intervention was determined by LVS. Methods: We included 159 patients with a leukoplakia of the vocal folds and 50 healthy controls. Clinicopathological data and LVS characteristics (amplitude, mucosal wave, nonvibratory segment, glottic closure, phase symmetry, periodicity) at the lesion site were obtained and compared with the histopathological results. LVS parameters were recorded before cordectomy and in a 12-month follow-up interval. Patients who had prior laryngosurgery, radiotherapy, or laryngeal scarring were excluded. Results: Absent or greatly reduced mucosal waves were found in all patients with an invasive carcinoma, in 94% with a severe intraepithelial neoplasia (SIN III), in 38% with a moderate squamous intraepithelial neoplasia (SIN II), in 32% with a mild squamous intraepithelial neoplasia (SIN I), and in 23% with a hyperkeratosis without dysplasia. The sensitivity and specificity of LVS in predicting an invasive carcinoma based on the absence or reduction of mucosal waves was 0.96 and 0.90, respectively. Following surgical intervention, the recovery rate of the mucosal wave and amplitude was 12% in the invasive carcinoma group, 36% in the SIN III group and up to 80% for both these parameters in the SIN I, SIN II, and hyperkeratosis groups. Conclusion: LVS is a valid tool to identify early glottic carcinoma and its high risk premalignancy carcinoma in situ (CIS). Even when there is no definitive differentiation between SIN I and II, the invasive character of a CIS and an invasive glottic carcinoma can be identified. Especially strobosopic signs of abnormal amplitude and/or mucosal waves, particularly phoniatric halt, are an early indication for a CIS or an invasive carcinoma.
The Clinical Challenges Experienced by New Graduate Occupational Therapists: A Matrix Review
Authors: Moir Elizabeth M. A. , Turpin Merrill J. , Copley Jodie A. 
Published: June 2021

Background. The transition from student to new graduate occupational therapist is recognized as stressful. Current literature has not specifically drawn together the challenges new graduates face when learning to work with clients. Purpose. This review aimed to synthesize common challenges that new graduate occupational therapists face when working with clients. Methods. Searches of online scholarly databases located research articles. Content related to working with clients in practice was charted using the Matrix Method. Findings. From 21 articles, four categories of challenges were identified: “reasoning and decision-making,” “using knowledge and skills in practice with clients,” “the context of service provision,” and “managing caseload and priorities.” “Having self-doubt” was a theme that pervaded the data. Implications. New graduates often do not feel fully prepared for all aspects of occupational therapy practice. As they may not have access to substantial workplace support, exploring personal resources and professional support may assist this challenging transition.
Double, triple or quadruple hits? Exploring the impact of cybercrime on victims in the Netherlands
Authors: Notté Raoul , Leukfeldt E.R. , Malsch Marijke 
Published: June 2021

This article explores the impact of online crime victimisation. A literature review and 41 interviews – 19 with victims and 22 with experts – were carried out to gain insight into this. The interviews show that most impacts of online offences correspond to the impacts of traditional offline offences. There are also differences with offline crime victimisation. Several forms of impact seem to be specific to victims of online crime: the substantial scale and visibility of victimhood, victimisation that does not stop in time, the interwovenness of online and offline, and victim blaming. Victims suffer from double, triple or even quadruple hits; it is the accumulation of different types of impact, enforced by the limitlessness in time and space, which makes online crime victimisation so extremely invasive. Furthermore, the characteristics of online crime victimisation greatly complicate the fight against and prevention of online crime. Finally, the high prevalence of cybercrime victimisation combined with the severe impact of these crimes seems contradictory with public opinion – and associated moral judgments – on victims. Further research into the dominant public discourse on victimisation and how this affects the functioning of the police and victim support would be valuable.
Endovascular Repair of Postdissection Thoracoabdominal Aortic Aneurysm in Patients With Vascular Ehlers-Danlos Syndrome
Authors: Eleshra Ahmed , Panuccio Giuseppe , Spanos Konstantinos , Rohlffs Fiona , Kodolitsch Yskertvon , Detter N. Christian , Tsilimparis Nikolaos , Kölbel Tilo 
Published: June 2021

Purpose To report endovascular repair of postdissection thoracoabdominal aortic aneurysm (TAAA) in 2 patients with vascular Ehlers-Danlos syndrome (vEDS). Case Reports Case 1. A 56-year-old vEDS male patient with a 50-mm type III TAAA [history of aortic root repair, hemiarch replacement, and thoracic endovascular aortic repair (TEVAR) for acute type A aortic dissection (TAAD) 7 years ago] was treated by a 2-stage procedure; first, cervical debranching of the left subclavian artery and second TEVAR and t-branch. The postoperative course was uneventful. Follow-up computed tomography angiography (CTA) 3.5 years postoperatively demonstrated aortic remodeling with patency of targeted visceral vessels and no endoleak. Case 2. A 47-year-old vEDS male patient presented with a TAAA (diameter of 67 mm). The patient had a history of aortic valve and arch replacement with elephant trunk for acute TAAD, and consequently a TEVAR and candy-plug procedure after a ruptured false lumen (FL) aneurysm of the descending thoracic aorta. He also had a surgical repair by an aorto-bi-iliac graft. Two years later, CTA demonstrated aneurysmal FL dilatation distally to the candy-plug and he was treated with fenestrated EVAR (F-EVAR). Conclusion Endovascular repair of postdissection TAAA was feasible and safe with good short-term outcome in 2 patients with vEDS.
Mechanical Effects of Lag Screw Retightening in a Simulated Hindfoot Arthrodesis Model
Authors: Rugg Amanda L. , Requist Melissa R. , Johnson Brooks W. , Son Michelle M. , Alvarez Alicia , Latt L. Daniel 
Published: June 2021

Background: Nonunion following hindfoot arthrodesis may be caused by failure to maintain compression at the arthrodesis site. The ability of lag screws, commonly used in arthrodesis, to maintain compression in hindfoot bones has not been well characterized. The aim of this work was to quantify the stress relaxation response of hindfoot bone with initial and repeated compression with a lag screw. Methods: Ten sets of 25-mm-diameter bone cylinders were cut from the talus and calcaneus in fresh-thawed cadaveric feet. A load cell was compressed between cylinders with an 8.0-mm partially threaded cannulated lag screw simulating arthrodesis. For 7 sets, screws were tightened by 3 quarter-turns, rested for 3 minutes, retightened 1 quarter-turn, and rested for 30 minutes. Three sets served as controls in which screws were not retightened. Results: Maximum compression after initial screw tightening and retightening averaged 275 and 337 N ( P = .07), respectively. Compression 3 minutes after initial screw tightening and retightening averaged 199 and 278 N ( P = .027), respectively. The compression recorded 3 minutes after screw retightening was an average of 40% higher than that recorded 3 minutes after initial tightening. The average compression 30 minutes after screw retightening was 255 N, a compression loss of 25% from the average maximum compression after retightening. Eighty percent of this compression loss happened in an average of 5.5 minutes. Conclusion: Hindfoot bones exhibit compression loss over time during simulated arthrodesis. Compression maintenance in bone is improved with screw retightening. Further work is needed to understand the mechanism of action and determine optimum time for recompression. Clinical Relevance: Retightening lag screws before wound closure may improve compression at the arthrodesis site and thereby decrease the chance of nonunion. Level of Evidence: N/A, laboratory experiment.
Intraspecific variation in the Cambrian: new observations on the morphology of the Chengjiang euarthropod Sinoburius lunaris
Authors: Schmidt Michel , Liu Yu , Hou Xianguang , Haug Joachim T. , Haug Carolin , Mai Huijan , Melzer Roland R. 
Published: June 2021

AbstractBackgroundThe Chengjiang biota from southwest China (518-million-years old, early Cambrian) has yielded nearly 300 species, of which more than 80 species represent early chelicerates, crustaceans and relatives. The application of µCT-techniques combined with 3D software (e.g., Drishti), has been shown to be a powerful tool in revealing and analyzing 3D features of the Chengjiang euarthropods. In order to address several open questions that remained from previous studies on the morphology of the xandarellid euarthropodSinoburius lunaris, we reinvestigated the µCT data with Amira to obtain a different approach of visualization and to generate new volume-rendered models. Furthermore, we used Blender to design 3D models showing aspects of intraspecific variation.ResultsNew findings are: (1) antennulae consist of additional proximal articles that have not been detected before; (2) compared to other appendages, the second post-antennular appendage has a unique shape, and its endopod is comprised of only five articles (instead of seven); (3) the pygidium bears four pairs of appendages which are observed in all specimens. On the other hand, differences between specimens also have been detected. These include the presence/absence of diplotergites resulting in different numbers of post-antennular appendages and tergites and different distances between the tip of the hypostome and the anterior margin of the head shield.ConclusionsThose new observations reveal intraspecific variation among Chengjiang euarthropods not observed before and encourage considerations about possible sexual dimorphic pairs or ontogenetic stages.Sinoburius lunarisis a variable species with respect to its morphological characters, cautioning that taxon-specific variabilities need to be considered when exploring new species.
Transcriptome analysis reveals Vernalization is independent of cold acclimation in Arabidopsis
Authors: Li Fei , Hu Qian , Chen Fadi , Jiang Jia Fu 
Published: June 2021

Abstract
Background
Through vernalization, plants achieve flowering competence by sensing prolonged cold exposure (constant exposure approximately 2-5 °C). During this process, plants initiate defense responses to endure cold conditions. Here, we conducted transcriptome analysis of Arabidopsis plants subjected to prolonged cold exposure (6 weeks) to explore the physiological dynamics of vernalization and uncover the relationship between vernalization and cold stress.

Results
Time-lag initiation of the two pathways and weighted gene co-expression network analysis (WGCNA) revealed that vernalization is independent of cold acclimation. Moreover, WGCNA revealed three major networks involving ethylene and jasmonic acid response, cold acclimation, and chromatin modification in response to prolonged cold exposure. Finally, throughout vernalization, the cold stress response is regulated via an alternative splicing-mediated mechanism.

Conclusion
These findings illustrate a comprehensive picture of cold stress- and vernalization-mediated global changes in Arabidopsis.
Therapeutic inertia in proteinuria management among type 2 diabetes (T2DM) patients in primary care settings: prevalence and associated risk factors
Authors: Chan FU Leung , Li Yim Chu , Chen Xiao Rui Catherine 
Published: June 2021

Abstract
Background
Therapeutic inertia (TI), defined as physicians’ failure to increase therapy when treatment goals are unmet, is an impediment to chronic disease management. This study aimed to identify the prevalence of TI in proteinuria management among T2DM patients managed in primary care settings and to explore possible associating factors.

Methods
This was a cross-sectional study. T2DM patients with proteinuria (either microalbuminuria or macroalbuminuria) and had been followed up in 7 public primary care clinics of the Hospital Authority of Hong Kong from 1 Jan, 2014 to 31 Dec, 2015 were included. The prevalence of TI in proteinuria management and its association with patients’ demographic and clinical parameters and the working profile of the attending doctors were explored. Student’s t test and analysis of variance were used for analyzing continuous variables and Chi square test was used for categorical data. Multivariate stepwise logistic regression was used to determine the association between TI and the significant variables from patients' and doctors' characteristics.

Results
Among the 22,644 T2DM patients identified in the case register, 5163 (26.4%) patients were found to have proteinuria. Among the sampled 385 T2DM patients with proteinuria, TI was identified in 155 cases, with a prevalence rate of 40.3%. Male doctor, doctor with longer duration of clinical practice and have never received any form of Family Medicine training were found to have a higher TI. Patients with microalbuminuria range and lower systolic and diastolic blood pressure (BP) were also found to have higher TI. Logistic regression study revealed that patients’ systolic BP level and microalbuminuria range of proteinuria were negatively associated with the presence of TI, whereas doctor’s year of clinical practice being over 20 years and patients being treated with submaximal dose of medication were positively associated with the presence of TI.

Conclusions
TI is commonly present in proteinuria management among T2DM patients, with a prevalence of 40.3% in primary care. Systolic BP and microalbuminuria range of urine ACR were negatively associated with the presence of TI, whereas submaximal ACEI/ARB dose and doctors practicing over 20 years were positively associated with the presence of TI. Further studies exploring the strategies to combat TI are needed to improve the clinical outcome of T2DM patients.
Exploring the impact of Patient Reported Outcome Measures (PROMs) among orthopaedic surgeons in mainland China: systematic review and survey-based study on hip and knee instruments
Authors: Ngwayi James Reeves Mbori , Tan Jie , Liang Ning , Obie Kenedy Uzoma , Porter Daniel Edward 
Published: June 2021

Abstract
Background
Patient Reported Outcome Measures (PROMs) are widely used in Europe and North America in a variety of areas including research, clinical governance, clinical registries and insurance ascertainment. The aim of this study was to assess commonly used knee and hip PROMs among Chinese surgeons and to gain an insight into their impact on evaluation of clinical outcomes.

Methods
1. A systematic literature search of databases Medline, EMBASE, CINAHL and CNKI was performed from the earliest records to 22/07/2020 for knee instruments and 22/08/2020 for hip instruments, to retrieve Chinese Mandarin cross culturally adapted and validated knee and hip PROMs. 2. An 11-item electronic questionnaire was then designed under four domain categories. The survey was distributed via a ubiquitous online social media platform to orthopaedic surgeons. Responses were collected and analyzed. Output from 1. was used to populate parts of the survey questionnaire.

Results
The systematic online search yielded a total of 41 evaluation instruments, (10 hip and 31 knee); all of which were incorporated as response options. 234 viable questionnaires were retrieved with the largest group representing attending surgeons. 59.0% were familiar with the concept of PROMs among which 78.4% reported to have used PROMs themselves. In order of frequency of use, PROMs were purposed for clinical assessment (55.6%), research (40.7%), health regulation policies (18.6%) and insurance service requirements (10.6%). Implementation was prompted by both departmental (43.4%) and institutional policy (34.5%). 89.4% of PROMs users reported difficulties in the use of PROMs, with major barriers including license fees, limited access, inadequate training and burden of fill-out time (all > 40%).

Conclusion
There is evidence of limited familiarity with knee and hip PROMs among orthopaedic surgeons. Barriers to their use are significant. Development of a Chinese language PROMs database would be helpful.
Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population
Authors: Kim Hang-Rai , Jung Sang-Hyuk , Kim Jaeho , Jang Hyemin , Kang Sung Hoon , Hwangbo Song , Kim Jun Pyo , Kim So Yeon , Kim Beomsu , Kim Soyeon , Jeong Jee Hyang , Yoon Soo Jin , Park Kyung Won , Kim Eun-Joo , Yoon Bora , Jang Jae-Won , Hong Jin Yong , Choi Seong Hye , Noh Young , Kim Ko Woon , Kim Si Eun , Lee Jin San , Jung Na-Yeon , Lee Juyoun , Kim Byeong C. , Son Sang Joon , Hong Chang Hyung , Na Duk L. , Seo Sang Won , Won Hong-Hee , Kim Hee Jin 
Published: June 2021

Abstract
Background
Genome-wide association studies (GWAS) have identified a number of genetic variants for Alzheimer’s disease (AD). However, most GWAS were conducted in individuals of European ancestry, and non-European populations are still underrepresented in genetic discovery efforts. Here, we performed GWAS to identify single nucleotide polymorphisms (SNPs) associated with amyloid β (Aβ) positivity using a large sample of Korean population.

Methods
One thousand four hundred seventy-four participants of Korean ancestry were recruited from multicenters in South Korea. Discovery dataset consisted of 1190 participants (383 with cognitively unimpaired [CU], 330 with amnestic mild cognitive impairment [aMCI], and 477 with AD dementia [ADD]) and replication dataset consisted of 284 participants (46 with CU, 167 with aMCI, and 71 with ADD). GWAS was conducted to identify SNPs associated with Aβ positivity (measured by amyloid positron emission tomography). Aβ prediction models were developed using the identified SNPs. Furthermore, bioinformatics analysis was conducted for the identified SNPs.

Results
In addition to APOE, we identified nine SNPs on chromosome 7, which were associated with a decreased risk of Aβ positivity at a genome-wide suggestive level. Of these nine SNPs, four novel SNPs (rs73375428, rs2903923, rs3828947, and rs11983537) were associated with a decreased risk of Aβ positivity (p < 0.05) in the replication dataset. In a meta-analysis, two SNPs (rs7337542 and rs2903923) reached a genome-wide significant level (p < 5.0 × 10−8). Prediction performance for Aβ positivity increased when rs73375428 were incorporated (area under curve = 0.75; 95% CI = 0.74–0.76) in addition to clinical factors and APOE genotype. Cis-eQTL analysis demonstrated that the rs73375428 was associated with decreased expression levels of FGL2 in the brain.

Conclusion
The novel genetic variants associated with FGL2 decreased risk of Aβ positivity in the Korean population. This finding may provide a candidate therapeutic target for AD, highlighting the importance of genetic studies in diverse populations.