bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved Incidence of Cardiovascular Disease in Patients With Incident Rheumatoid Arthritis in the 2000s: A Population-based Cohort Study
Authors: Myasoedova Elena , Davis John M. , Roger Veronique L. , Achenbach Sara J. , Crowson Cynthia S. 
Published: February 2021

ObjectiveTo assess trends in incidence of cardiovascular disease (CVD) and mortality following incident CVD events in patients with rheumatoid arthritis (RA) onset in 1980–2009 vs non-RA subjects.MethodsWe studied Olmsted County, Minnesota residents with incident RA (aged > 18 yrs, 1987 American College of Rheumatology criteria met in 1980–2009) and non-RA subjects from the same source population with similar age, sex, and calendar year of index. All subjects were followed until death, migration, or December 31, 2016. Incident CVD events included myocardial infarction and stroke. Patients with CVD before RA incidence/index date were excluded. Cox models were used to compare incident CVD events by decade, adjusting for age, sex, and CVD risk factors.ResultsThe study included 905 patients with RA and 904 non-RA subjects. Cumulative incidence of any CVD event was lower in patients with incident RA in the 2000s vs the 1980s. The HR for any incident CVD in the 2000s vs 1980s was 0.53 (95% CI 0.31–0.93). The strength of association attenuated after adjustment for anti-rheumatic medication use (HR 0.64, 95% CI 0.34–1.22). Patients with RA in the 2000s had no excess in CVD over non-RA subjects (HR 0.71, 95% CI 0.42–1.19). Risk of death after a CVD event was somewhat lower in patients with RA after the 1980s with an HR of 0.54 (95% CI 0.33–0.90) in the 1990s vs 1980s and 0.68 (95% CI 0.33–1.41) in the 2000s vs 1980s.ConclusionThe incidence of major CVD events in RA has declined in recent decades. The gap in CVD occurrence between patients with RA and the general population is closing. Mortality after CVD events in RA may be improving.
Diagnostic Delay in Psoriatic Arthritis: A Population-based Study
Authors: Karmacharya Paras , Wright Kerry , Achenbach Sara J. , Bekele Delamo , Crowson Cynthia S. , Ogdie Alexis , Duarte-García Alí , Ernste Floranne C. , Tollefson Megha M. , Davis John M. 
Published: February 2021

ObjectiveTo examine demographic and clinical characteristics associated with diagnostic delay in psoriatic arthritis (PsA).MethodsWe characterized a retrospective, population-based cohort of incident adult (≥ 18 yrs) patients with PsA from Olmsted County, Minnesota, from 2000–2017. All patients met the classification criteria. Diagnostic delay was defined as the time from any patient-reported PsA-related joint symptom to a physician diagnosis of PsA. Factors associated with delay in PsA diagnosis were identified through logistic regression models.ResultsOf the 164 incident PsA cases from 2000 to 2017, 162 had a physician or rheumatologist diagnosis. Mean (SD) age was 41.5 (12.6) years and 46% were female. Median time from symptom onset to physician diagnosis was 2.5 years (IQR 0.5–7.3). By 6 months, 38 (23%) received a diagnosis of PsA, 56 (35%) by 1 year, and 73 (45%) by 2 years after symptom onset. No significant trend in diagnostic delay was observed over calendar time. Earlier age at onset of PsA symptoms, higher BMI, and enthesitis were associated with a diagnostic delay of > 2 years, whereas sebopsoriasis was associated with a lower likelihood of delay.ConclusionIn our study, more than half of PsA patients had a diagnostic delay of > 2 years, and no significant improvement in time to diagnosis was noted between 2000 and 2017. Patients with younger age at PsA symptom onset, higher BMI, or enthesitis before diagnosis were more likely to have a diagnostic delay of > 2 years, whereas patients with sebopsoriasis were less likely to have a diagnostic delay.
Concevoir une formation en ligne à partir d’une étude sur les enjeux interculturels des ingénieurs
Authors: Le Forestier Mélanie 
Published: February 2021

Dans cet article, nous présenterons le processus de conception d’une formation en ligne appelée POMI (Préparer et Optimiser sa Mobilité Internationale) destinée à des élèves-ingénieurs, mais qui peut être transposée dans d’autres contextes de formation. Le principal objectif pédagogique est d’accompagner les apprenants dans le développement d’une démarche interculturelle en s’appuyant sur leur expérience de mobilité internationale, obligatoire en formation d’ingénieur. La particularité de ce projet a été d’articuler ce travail d’ingénierie pédagogique à une recherche visant à identifier, au préalable, les besoins spécifiques des formations d’ingénieur en matière d’interculturalité. Nous proposons donc une conceptualisation du développement interculturel dans un modèle de « démarche interculturelle » qui a permis de construire un dispositif de formation adapté aux enjeux interculturels rencontrés par les ingénieurs professionnels. En première partie d’article, nous préciserons la façon dont nous nous saisissons du champ de l’interculturalité et comment cela nous a permis de proposer une conceptualisation de ce que nous appelons une démarche interculturelle dans un contexte ingénieur. Nous montrerons ensuite comment le modèle de démarche interculturelle a servi à construire le scénario et le cheminement pédagogique du dispositif POMI. La formation étant toujours en cours de construction, nous conclurons l’article en présentant la pédagogie privilégiée et qui correspond à celle que nous proposons aux enseignants et responsables pédagogiques qui souhaitent intégrer la dimension interculturelle dans leur pratique enseignante.
Designing a Pustekipad Computer Laboratory Loan Application for Learning ICT Subjects
Authors: Syafrizal Reza , Tabrani Ahmad 
Published: February 2021

This study explores the management system of technology center and database laboratory which is far from being optimal to facilitate ICT course. This study aims at developing an application used to facilitate ICT learning in order to optimize the computer laboratory use and make it more systematic. The method used in this research is a descriptive qualitative method. The data were collected through observation. The result of the study shows that the application which was developed could simplify the work of the users and administrators in the computer laboratory management system.
Tulisan ini dilatarbelakangi oleh belum optimalnya pemanfaatan laboratorium komputer pustekipad (Pusat Teknologi Informasi dan Pangkalan Data) untuk pembelajaran mata kuliah TIK. Dari permasalahan tersebut maka penulis melakukan penelitian untuk membuat sebuah aplikasi peminjaman laboratorium komputer tersebut. Metode yang digunakan dalam penelitian ini menggunakan metode deskriptif kualitatif. Metode observasi juga digunakan dalam pembuatan tulisan ini. Hasil penelitian berupa aplikasi yang digunakan untuk memudahkan penggunaan laboratorium komputer pustekipad untuk pembelajaran TIK. Dosen dan sivitas akademika yang menjadi pengguna di dalam laboratorium ini dengan mudah melakukan peminjaman laboratorium dengan memanfaatkan aplikasi yang telah dibuat. Hal itu mempermudah pengguna dan administrator dalam pengelolaan laboratorium.
Relationship among the Actors and Levels of Trust in Secondary Education Centers of the Guayaquil Canton (Ecuador)
Authors: Franco Pombo Mónica Rebeca , Fernández Martínez María del Mar , Luque de la Rosa Antonio , Gutiérrez Cáceres Rafaela 
Published: February 2021

The public policy of Ecuador has placed the improvement of educational quality as one of the main objectives of government management. The climate-school constructs, organizational climate, work climate, and institutional climate, are used in different environments to accentuate the importance of the relationship established between a management environment ­ factor and the quality of results in organizations.
Throughout this study, the objective has been to analyze the variations in the relationship among the actors, and the levels of trust between the actors of the school organizational climate, according to the socioeconomic level, the role played in the educational community, or the type of socio-educational center.
The study follows a new approach of an experimental, descriptive-comparative investigation, using techniques such as the survey, the interview, and the discussion group, adjusting to the mixed methodology according to the objectives and sense of the research proposed.
In consideration of the results, we will appreciate that the relationships between the actors and the confidence levels of the actors show mostly positive indicators based on the responses of the participants in the study. However, the percentage of negative perceptions (24.34%) is a factor to consider, since it might suggest that these perceptions underlie indicators of distrust that should be taken into account for any future interventions.
In conclusion, the schools participating in this study have built a mostly positive school organizational climate, which generates favorable spaces for innovation and change processes.
La recuperación de la universalidad de la asistencia sanitaria tras el Real Decreto-ley 7/2018, de 27 de julio
Authors: López Insua Belén del Mar 
Published: February 2021

El derecho a la salud se configura, dada su equivocada ubicación en el texto constitucional, como un principio rector de la política social y económica (artículo 43 de la CE) al que se le otorga una debilitada protección que no queda exenta de críticas. Son muchos los vaivenes que, en torno a esta materia, ha protagonizado la doctrina del Tribunal Constitucional. Sin embargo, lo cierto es que a pesar del constante tira y afloja, el derecho a la salud se ha erigido en pilar fundamental para la construcción de un constitucionalismo democrático-social que pretende dar primacía a los ciudadanos (derecho subjetivo) frente a los intereses económicos y mercantilistas propios de sociedades poco inclusivas. Por todo ello, al derecho a la salud se le otorga y reconoce (tanto en la normativa internacional, como en la comunitaria) el carácter de derecho primario y fundamental vinculado al derecho a la vida, a la integridad física y la dignidad de toda persona. En esta línea, se sitúa el Real Decreto-Ley 7/2018, de 27 de julio, sobre el acceso universal al Sistema Nacional de Salud. Y es que, gracias a esta normativa, el derecho a la asistencia sanitaria se configura ahora como un derecho de ciudadanía, de carácter universal y no solamente ligado a la nacionalidad y a la residencia legal, por lo que el mismo se hará igualmente extensible (aunque con alguna limitación) a las personas que se encuentren irregularmente en España.
Pinus tabulaeformis Pollen as Replacement for 17-alpha-methyltestosterone in the Diet of Oreochromis niloticus Larvae for Sex Reversal and Growth
Authors: Nian Cherry T. , Tumbokon Barry Leonard M. , Serrano Augusto E. 
Published: February 2021

Three experiments were conducted to investigate the use of pollen from Pinus tabulaeformis (PP), as a possible replacement for synthetic 17-alpha-methyltestosterone (MT) in Nile tilapia, Oreochromis niloticus larvae diets. In experiment 1, the attractability of a diet containing PP (640mg/kg) compared to a control diet containing no PP was assessed. Experiment 2, lasting 8 weeks, evaluated the effects of PP on growth, food conversion efficiency, survival, and sex inversion compared with that of 17a-methyltestosterone (MT). Results showed that after 60 days of feeding, 100% of Nile tilapia fed the MT diet converted to male; this was statistically similar to the percentage of fish fed the PP diets (81.0% to 89.1% male, p<0.05). Results of the growth trial showed that final weight (FW) and weight gain (WG) of fish fed diets containing 0.08 g/kg PP and 0.64 g PP/kg were significantly higher than those fed the MT diet (p<0.05). Feed intake (FI) of all experimental fish were statistically similar (p>0.05). The group fed 0.08 g PP/kg diet exhibited significantly higher SGR than the MT group. The MT group exhibited lower food conversion efficiency (i.e. higher FCR) than the control group. Fish fed diets containing 0.08 and 0.64 g PP/kg exhibited better FCR than those fed the MT diet. Survival was statistically similar for all dietary treatments (p>0.05). In experiment 3, fish larvae were fed: no PP (control diet), a medium dose (0.32 g/kg), and a high dose (0.64 g/kg) of PP for 14 days and assayed for alpha amylase and trypsin activities. Results showed that diets containing PP were significantly more attractive to the fish than the control diet (p<0.05) for the first 5 min. At the 6th min, results were statistically similar for both PP diets. In conclusion, PP could replace MT in effecting sex reversal from female to male with statistically similar results; it could also promote better growth and food conversion efficiency at the minimum dietary level of 0.08 mg PP/kg.
ROLE OF ARKA TAILA AND BAAKUCHIKADYAM CHURNA ON VICHARCHIKA: A RANDOMIZED CONTROL TRIAL
Authors: Sheetal Yadav  , Anita Sharma  , Dinesh C. Chouhan  
Published: February 2021

In the present era skin diseases like atopic dermatitis/eczema get a suitable atmosphere especially in developing countries like India, due to unhygienic living condition, Disturbed life style, Polluted environment and repeated use of chemical additives. This type of diseases make a person feels much more humiliation in society because no one wants to touch them, forbidden by everyone, in that conditions person leads to lack of confidence and feels underestimated mentally as well as physically. Due to this life disturbing condition this disease was chosen for the study.
The study was conducted in 30 clinically diagnosed patients of Vicharchika (Atopic Dermatitis) and randomly divided in to two groups, namely group A and group B. Each group has 15 number of patients. Group A is treated with Arka Taila (external application) used twice in a day for 45 days along with Baakuchikadyam Churna for internal consumption (3-6 grams). Group B is treated with Cutis Capsule (2 Capsules) twice a day orally along with external application of Cutis Cream as required for 45 days.
Acrylic Foreign Body in the Orbit: A Multidisciplinary Approach
Authors: Dhorje Nikhil Rajendra , Shah Kshitij Dhaval , V Madhusudhan , Kulkarni Pushkaraj Abhay , Bradoo Renuka Anil 
Published: February 2021

Introduction
Foreign body in the eye is one of the leading causes of temporary as well as permanent visual problems in developing world.
Case Report
We are presenting a case of 17 year old male with alleged history of traumatic insertion of foreign body acrylic glass in right orbit due to bursting of cracker in acrylic bottle and its subsequent management.
Discussion
It was removed with endoscopic guidance and floor of orbit was reconstructed to provide stability to eyeball and also to prevent secondary complications. We present this case to highlight importance of multidisciplinary approach in tertiary health care centre.
Hydatid Cyst of Submandibular Region
Authors: Phookan Jyotirmoy , Chatterjee Pritam , De Sritama 
Published: February 2021

Introduction
Hydatid cysts in the neck are relatively exceptional. We report a rare case of a hydatid cyst localized in the right submandibular region of the neck with a second cyst in lung discussing diagnostic and management algorithm with brief review of literature.
Case Report
A 6 years old boy presented to us in Gauhati Medical College & Hospital with a gradually enlarging painless swelling in right submandibular region since last 4 months. The patient was thoroughly evaluated. Imaging and FNAC was performed. Suspected common locations were also screened prior to surgery. He was treated with total pericystectomy and followed up regularly.
Discussion
Hydatid disease is a widespread public health problem in developing countries. The possibility of hydatid disease, especially in endemic regions, may always be considered in the differential diagnosis of mesenchymal neoplasms or soft tissue cystic masses in the neck. Radiologic imaging modalities in such cases are mandatory for the diagnosis. The prognosis is excellent in hydatid cyst cases treated with total removal of the cyst without rupture.
Different Faces of Sinonasal Mass Lesions
Authors: T Devika , Bhat Shubha P , Bhat Vadisha Srinivas , Aroor Rajeshwary , Bhandary B Satheesh Kumar , MK Gautham , KJ Samatha 
Published: February 2021

Introduction
Mass in the nasal cavity presents with a wide range of symptoms, when a presumptive diagnosis is often made with the help of imaging and endoscopy. This study focussed on correlating clinical diagnosis with the histopathological diagnosis so that appropriate treatment can be offered to improve the quality of life of the patient.
Materials and Methods
The study included 120 cases who presented with symptoms and signs of mass in the nasal cavity, undergoing surgery or diagnostic biopsy. They were evaluated with a detailed history and clinical examination, diagnostic nasal endoscopy, and relevant radiological investigations. Histopathological examination of the biopsy of the excised specimen was performed by Haematoxylin and Eosin stain. Special stains and Immunohistochemistry (IHC) were performed whenever indicated. The clinical diagnosis was correlated with histopathological diagnosis.
Results
Nasal obstruction was the most frequent symptom followed by nasal discharge. Non-neoplastic lesions made up 85% of cases, while16% of cases were proved as neoplastic lesions. Among neoplastic lesions, 7% were benign, and 9% were malignant. The inflammatory polyp was the most common non-neoplastic lesion. Fischer's exact test showed a correlation between clinical diagnosis and histopathological diagnosis. Non-neoplastic lesions were common in the 4th decade of life; benign lesions were common in the 3rd decade of life, while malignant lesions were common in the 5th decade of life.
Conclusion
Sinonasal masses present with overlapping clinical features, and sometimes the definite diagnosis is possible only by histopathological examination of the specimen. However, in the presence of characteristic clinical features, accurate clinical diagnosis is possible in most cases, and appropriate treatment can be performed without delay, pending histopathological examination.
Usefulness of The Reflux Symptom Index in the Management of Laryngopharyngeal Reflux
Authors: Thejas Saai Ram , Rajamohan Ganganamoni , Mohan Sindu , Swarna Kowsalya 
Published: February 2021

Introduction
Laryngopharyngeal Reflux (LPR) is highly prevalent in the general population and its impact on health systems is growing dramatically by the day. The contents of the stomach flowing back into the oesophagus, pharynx and larynx because of a transient relaxation of the lower oesophageal sphincter leads to a spectrum of symptoms diagnosed as LPR and Gastroesophageal Reflux Disease (GERD). The aim was to study in detail the symptoms of LPR and to ascertain if and how they hamper the routine of an individual by using the Reflux Symptom Index (RSI).
Materials and Methods
The Reflux Symptom Index (RSI) is a self-administered nine-item outcomes instrument for LPR. Ninety-one patients with clinically diagnosed LPR were taken up for this study and were issued the RSI (translated into the local language for better results) before and after treatment. Data was assessed at the end of 3 months and 6 months.
Results
The tabulated data showed significant improvement in the symptomatic index after treatment.
Conclusion
It can thus be concluded that RSI is still highly valid in the follow-up for patients with LPR because it can be easily administered and gives accurate results with excellent validation.
Midline Nasal Tip Sinus
Authors: Gupta Nitin , Gupta Himani , Singhal Surinder Kumar 
Published: February 2021

Introduction
Congenital midline sinus over tip of nose is a rare clinical presentation. Accurate diagnosis should be done to rule out intracranial extension and to prevent recurrence. Appropriate surgical approach depends upon location, extent and degree of intracranial extension. Management entails complete surgical excision of sinus tract. We discuss a rare case, where external rhinoplasty approach was used for excising recurrent sinus and patient was disease free.
Case Report
A 29 year old male patient with midline nasal tip sinus presented in our institute with history of opening over tip of nose since childhood associated with recurrent episodes of discharge from opening. Our objective is to present clinic-radiological-pathological profile of congenital nasal sinus along with review of literature.
Discussion
Nasal dermoid is rare embryological anomaly of ectodermal and mesodermal origin. Radiological imaging should be considered to rule out any intracranial extension. Goal of management is complete surgical excision with meticulous pre-operative and surgical planning to avoid complications and recurrence. External rhinoplasty provides best surgical exposure and allows excision of sinus tract.
Complications of Thyroidectomy in Hashimoto Thyroiditis vis-à-vis Benign Goitres
Authors: Lasrado Savita , Aramani Anita , Hegde Aishwarya , Moras Kuldeep , Dsouza Cimona 
Published: February 2021

Introduction
Surgery for Hashimoto thyroiditis (HT) can be difficult due to dense inflammatory process surrounding the gland and postoperatively patient can develop hypocalcaemia, recurrent laryngeal nerve injury, haematoma and infection. Purpose of this study was to compare the rate of post-operative complications in HT with that in benign goitres.
Materials and Methods
Data of the patients, who underwent thyroidectomy for benign goitres between January 2013 and December 2017, were reviewed retrospectively. Patients were divided in to two groups. Group A included patients confirmed to have Hashimoto thyroiditis (n=148) and Group B included patients who underwent thyroidectomy for other benign thyroid disorders (n=430).
Results
A total of 578 patients who underwent thyroidectomy for benign thyroid diseases were included in the present retrospective study. Group A consisted of 148 patients who had HT. Group B consisted of 430 patients who had other benign thyroid diseases. The data was analysed using SPSS 23 and p-value < 0.05 was considered as statistically significant. Patients undergoing thyroidectomy in HT had significantly higher post-operative complication rate (p<0.005). Of the 148 patients with HT, 31.6% (77) had hypocalcaemia while 68.4% (167) with benign goitres had hypocalcaemia. In addition, 51.8% of the patients in the HT group were later diagnosed with malignancy; there were no malignancies present in the group B.
Conclusion
Though patients with HT suffer higher rate of complications after thyroidectomy when compared to benign goitres, careful pre-operative planning and risk counselling of patients with improved surgical techniques helps to minimize postoperative morbidity.