bluuebunny/crossref_metadata_2025_split huggingface dataset:
Least-squares reverse-time migration with sparsity constraints
Authors: Wu Di , Wang Yanghua , Cao Jingjie , da Silva Nuno V , Yao Gang 
Published: May 2021

Abstract
Least-squares reverse-time migration (RTM) works with an inverse operation, rather than an adjoint operation in a conventional RTM, and thus produces an image with a higher resolution and more balanced amplitude than the conventional RTM image. However, least-squares RTM introduces two side effects: sidelobes around reflectors and high-wavenumber migration artifacts. These side effects are caused mainly by the limited bandwidth of seismic data, the limited coverage of receiver arrays and the inaccuracy of the modeling kernel. To mitigate these side effects and to further boost resolution, we employed two sparsity constraints in the least-squares inversion operation, namely the Cauchy and L1-norm constraints. For solving the Cauchy-constrained least-squares RTM, we used a preconditioned nonlinear conjugate-gradient method. For solving the L1-norm constrained least-squares RTM, we modified the iterative soft thresholding method. While adopting these two solution methods, the Cauchy-constrained least-squares RTM converged faster than the L1-norm constrained least-squares RTM. Application examples with synthetic data and laboratory modeling data demonstrated that the constrained least-squares RTM methods can mitigate the side effects and promote image resolution.
Case Report: Scarring Alopecia After Scalp Avulsion
Authors: Lorei Nathan C , Sullivan John F , Lennon Robert P , Milder Edmund A , Roman John W 
Published: May 2021

ABSTRACTScalp avulsion is a rare trauma in the developed world but is a common injury in countries with poorly established infrastructure and safety regulations. This case reports the long-term sequelae of this injury, observed while conducting a humanitarian mission, and discusses immediate actions for management in an acute setting. We aim to increase awareness about this injury, its risk factors, and treatment options to better prepare clinicians in the developed world to provide care for this condition in the austere environment, which may include not only chronic pain, functional, and aesthetic concerns, but also a psychological impact that persists years after the initial injury.
Promoting Compliance to COVID-19 Vaccination in Military Units
Authors: Segal David , Arzi Yonatan Ilibman , Bez Maxim , Cohen Matan , Rotschield Jacob , Fink Noam , Karp Erez 
Published: May 2021

ABSTRACT

Background
On December 27th, 2020, the Israeli Defense Forces initiated a mass COVID-19 vaccination campaign aiming to vaccinate its personnel. This population upheld specific characteristics in terms of age and sex, lack of significant comorbidities, and a general scarcity of risk factors for sustaining a severe COVID-19 illness. We present the measures taken to increase vaccination compliance, and the vaccination rate that followed these actions. Our secondary goal was to compare between vaccination rates in frontline battalions and highly essential military units (group A) and rear administration and support military units (group B).

Methods
This was a retrospective review that included 70 military units that were composed of 18,719 individuals of both sexes, mostly free of significant comorbidities. We divided the challenges of maximizing vaccination rates into two main categories: vaccine compliance (including communication and information) and logistical challenges. We compared the vaccination rates in groups A and B using a multivariable linear regression model. A P-value of .05 was considered significant.

Results
The mean age in 70 military units was 22.77 ± 1.35 (range 18-50) years, 71.13% males. A total of 726 (3.88%) individuals have been found positive for SARS-CoV-2 between March 1st, 2020 and February 18th, 2021. On February 18th, 2021, 54 days after the vaccination campaign was launched, 15,871 (84.79%) of the study population have been vaccinated by the first dose of Pfizer COVID-19 vaccine, expressing an 88.21% compliance rate (excluding recovered COVID-19 cases who were not prioritized to be vaccinated at this stage). Vaccination compliance in military units from group A was found to be higher when compared to group B (P &lt; .001), leading to a 90.02% of group A population being either previously SARS-CoV-2 positive or COVID-19 vaccinated.

Conclusions
A designated army campaign led by a multidisciplinary team could rapidly achieve a high COVID-19 vaccination rate. The information presented can serve organizations worldwide with similar characteristics that plan a mass COVID-19 vaccination campaign.
Resolving the ultraluminous X-ray sources in the Ly α emitting galaxy Haro 11
Authors: Gross Arran C , Prestwich Andrea , Kaaret Philip 
Published: May 2021

ABSTRACT
Lyman continuum and line emission are thought to be important agents in the reionization of the early Universe. Haro 11 is a rare example of a local galaxy in which Ly α and continuum emission have escaped without being absorbed or scattered by ambient gas and dust, potentially as a consequence of feedback from its X-ray sources. We build on our previous Chandra analysis of Haro 11 by analysing three new observations. Our subpixel spatial analysis reveals that the two previously known X-ray sources are each better modelled as ensembles of at least two unresolved point sources. The spatial variability of these components reveals X1 as a dynamical system where one luminous X-ray source (LX ∼ 1041 erg s−1) fades as a secondary source begins to flare. These might be intermediate-mass black holes or low-luminosity active galactic nuclei (AGNs) near the centre of the galaxy in the process of merging. Optical emission line diagnostics drawn from the literature suggest that while the galaxy as a whole is consistent with starburst signatures of ionization, the individual regions wherein the X-ray sources reside are more consistent with AGN/composite classification. The sources in X2 exhibit some degree of flux variability. X2a dominates the flux of this region during most observations (LX ∼ 6 × 1040 erg s−1), and gives the only evidence in the galaxy of a soft ultraluminous X-ray source capable of high-energy winds, which we suggest are responsible for allowing the coincident Ly α emission to escape.
Can cosmological simulations capture the diverse satellite populations of observed Milky Way analogues?
Authors: Font Andreea S , McCarthy Ian G , Belokurov Vasily 
Published: May 2021

ABSTRACT
The recent advent of deep observational surveys of local Milky Way ‘analogues’ and their satellite populations allows us to place the Milky Way in a broader cosmological context and to test models of galaxy formation on small scales. In this study, we use the Lambda cold dark matter (ΛCDM)-based ARTEMIS suite of cosmological hydrodynamical simulations containing 45 Milky Way analogue host haloes to make comparisons to the observed satellite luminosity functions, radial distribution functions, and abundance scaling relations from the recent Local Volume and SAGA observational surveys, in addition to the Milky Way and M31. We find that, contrary to some previous claims, ΛCDM-based simulations can successfully and simultaneously capture the mean trends and the diversity in both the observed luminosity and radial distribution functions of Milky Way analogues once important observational selection criteria are factored in. Furthermore, we show that, at fixed halo mass, the concentration of the simulated satellite radial distribution is partly set by that of the underlying smooth dark matter halo, although stochasticity due to the finite number of satellites is the dominant driver of scatter in the radial distribution of satellites at fixed halo mass.
Modeling the Evolutionary Architectures of Transcribed Human Enhancer Sequences Reveals Distinct Origins, Functions, and Associations with Human Trait Variation
Authors: Fong Sarah L , Capra John A 
Published: May 2021

Abstract
Despite the importance of gene regulatory enhancers in human biology and evolution, we lack a comprehensive model of enhancer evolution and function. This substantially limits our understanding of the genetic basis of species divergence and our ability to interpret the effects of noncoding variants on human traits.
To explore enhancer sequence evolution and its relationship to regulatory function, we traced the evolutionary origins of transcribed human enhancer sequences with activity across diverse tissues and cellular contexts from the FANTOM5 consortium. The transcribed enhancers are enriched for sequences of a single evolutionary age (“simple” evolutionary architectures) compared with enhancers that are composites of sequences of multiple evolutionary ages (“complex” evolutionary architectures), likely indicating constraint against genomic rearrangements. Complex enhancers are older, more pleiotropic, and more active across species than simple enhancers. Genetic variants within complex enhancers are also less likely to associate with human traits and biochemical activity. Transposable-element-derived sequences (TEDS) have made diverse contributions to enhancers of both architectures; the majority of TEDS are found in enhancers with simple architectures, while a minority have remodeled older sequences to create complex architectures. Finally, we compare the evolutionary architectures of transcribed enhancers with histone-mark-defined enhancers.
Our results reveal that most human transcribed enhancers are ancient sequences of a single age, and thus the evolution of most human enhancers was not driven by increases in evolutionary complexity over time. Our analyses further suggest that considering enhancer evolutionary histories provides context that can aid interpretation of the effects of variants on enhancer function. Based on these results, we propose a framework for analyzing enhancer evolutionary architecture.
Bartonella Seroreactivity Among Persons Experiencing Homelessness During an Outbreak of Bartonella quintana in Denver, Colorado, 2020
Authors: McCormick David W , Rowan Sarah E , Pappert Ryan , Yockey Brook , Dietrich Elizabeth A , Petersen Jeannine M , Hinckley Alison F , Marx Grace E 
Published: May 2021

Abstract
During a recent outbreak of Bartonella quintana disease in Denver, 15% of 241 persons experiencing homelessness who presented for severe acute respiratory syndrome coronavirus 2 testing were seroreactive for Bartonella. Improved recognition of B quintana disease and prevention of louse infestation are critical for this vulnerable population.
Development of a Multifaceted Antimicrobial Stewardship Curriculum for Undergraduate Medical Education: The Antibiotic Stewardship, Safety, Utilization, Resistance, and Evaluation (ASSURE) Elective
Authors: Wang Rebecca , Degnan Kathleen O , Luther Vera P , Szymczak Julia E , Goren Eric N , Logan Ashleigh , Shnekendorf Rachel , Hamilton Keith W 
Published: May 2021

Abstract
To address the growing need for dedicated stewardship training in undergraduate medical education, we developed an antimicrobial stewardship curriculum for medical students with the objectives of increasing expertise in antimicrobial prescribing, introducing antimicrobial stewardship fundamentals, and enhancing comfort with engagement in interprofessional antimicrobial stewardship activities.
Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection
Authors: Trivedi Shubhanshi , Grossmann Allie H , Jensen Owen , Cody Mark J , Wahlig Taylor A , Hayakawa Serpa Paula , Langelier Charles , Warren Kristi J , Yost Christian C , Leung Daniel T 
Published: May 2021

Abstract

Background
Pneumonia and diarrhea are among the leading causes of death worldwide, and epidemiological studies have demonstrated that diarrhea is associated with an increased risk of subsequent pneumonia. Our aim was to determine the impact of intestinal infection on innate immune responses in the lung.

Methods
Using a mouse model of intestinal infection by Salmonella enterica serovar Typhimurium (S. Typhimurium [ST]), we investigated associations between gastrointestinal infections and lung innate immune responses to bacterial (Klebsiella pneumoniae) challenge.

Results
We found alterations in frequencies of innate immune cells in the lungs of intestinally infected mice compared with uninfected mice. On subsequent challenge with K. pneumoniae, we found that mice with prior intestinal infection have higher lung bacterial burden and inflammation, increased neutrophil margination, and neutrophil extracellular traps, but lower overall numbers of neutrophils, compared with mice without prior intestinal infection. Total numbers of dendritic cells, innate-like T cells, and natural killer cells were not different between mice with and without prior intestinal infection.

Conclusions
Together, these results suggest that intestinal infection impacts lung innate immune responses, most notably neutrophil characteristics, potentially resulting in increased susceptibility to secondary pneumonia.
Herb and conifer roots show similar high sensitivity to water deficit
Authors: Bourbia Ibrahim , Pritzkow Carola , Brodribb Timothy J 
Published: May 2021

Abstract
Root systems play a major role in supplying the canopy with water, enabling photosynthesis and growth. Yet, much of the dynamic response of root hydraulics and its influence on gas exchange during soil drying and recovery remains uncertain. We examined the decline and recovery of the whole root hydraulic conductance (Kr) and canopy diffusive conductance (gc) during exposure to moderate water stress in two species with contrasting root systems: Tanacetum cinerariifolium (herbaceous Asteraceae) and Callitris rhomboidea (woody conifer). Optical dendrometers were used to record stem water potential at high temporal resolution and enabled non-invasive measurements of Kr calculated from the rapid relaxation kinetics of water potential in hydrating roots. We observed parallel declines in Kr and gc to &lt;20% of unstressed levels during the early stages of water stress in both species. The recovery of Kr after rewatering differed between species. T. cinerariifolium recovered quickly, with 60% of Kr recovered within 2 h, while C. rhomboidea was much slower to return to its original Kr. Recovery of gc followed a similar trend to Kr in both species, with C. rhomboidea slower to recover. Our findings suggest that the pronounced sensitivity of Kr to drought is a common feature among different plant species, but recovery may vary depending on root type and water stress severity. Kr dynamics are proposed to modulate gc response during and following drought.
High-throughput genotype-based population structure analysis of selected buffalo breeds
Authors: Thakor Prakash B , Hinsu Ankit T , Bhatia Dhruv R , Shah Tejas M , Nayee Nilesh , Sudhakar A , Rank Dharamshibhai N , Joshi Chaitanya G 
Published: May 2021

AbstractIndia is considered as the home tract of some of the best buffalo breeds. However, the genetic structure of the Indian river buffalo is poorly understood. Hence, there is a need to characterize the populations and understand the genetic structure of various buffalo breeds for selection and to design breeding strategies. In this study, we have analyzed genetic variability and population structure of seven buffalo breeds from their respective geographical regions using Axiom Buffalo Genotyping Array. Diversity, as measured by expected heterozygosity, ranged from 0.364 in Surti to 0.384 in Murrah breed, and pair-wise FST values revealed the lowest genetic distance between Murrah and Nili-Ravi (0.0022), while the highest between Surti and Pandharpuri (0.030). Principal component analysis and structure analysis unveiled the differentiation of Surti, Pandharpuri, and Jaffarabadi in first two principal components and at K = 4, respectively, while remaining breeds were grouped together as a separate single cluster and admixed. Murrah and Mehsana showed early linkage disequilibrium (LD) decay, while Surti breed showed late decay. In LD blocks to quantitative trait locis (QTLs) concordance analysis, 4.65% of concordance was observed with 873 LD blocks overlapped with 2,330 QTLs. Overall, total 4,090 markers were identified from all LD blocks for six types of traits. Results of this study indicated that these single-nucleotide polymorphism (SNP) markers could differentiate phenotypically distinct breeds like Surti, Pandharpuri, and Jaffarabadi but not others. So, there is a need to develop SNP chip based on SNP markers identified by sequence information of local breeds.
Nutrient intake and influence on markers of oxidative stress in zoo-managed male snow leopards (Uncia uncia)
Authors: Iske Cayla J , Herrick Jason R , Morris Cheryl L 
Published: May 2021

Abstract
Oxidative stress (OS) results from the overproduction of reactive species. Nutrient intake can contribute positively or negatively to OS, and the lack of established nutrient requirements for most of the exotic species managed in zoos exacerbates the possibilities for nutrient imbalances that potentially could lead to reactive species production. The objective of this study was to evaluate the influence of nutrient intake and nutritional husbandry on markers of OS in male snow leopards (n = 14) maintained in U.S. facilities (n = 12). Diet samples and husbandry information were obtained and snow leopards were immobilized once for collection of blood. Samples were analyzed for chemical composition (diet and blood), antioxidant capacity (blood), and markers of OS (blood). Correlations between weekly nutrient intakes and markers of OS were analyzed by linear regression. Analyzed markers of OS included antioxidant enzymes (superoxide dismutase [SOD] and glutathione peroxidase [GPx]) and ferric reducing antioxidant potential that are protective against OS, and protein carbonyls, thiobarbituric acid reactive substances, and DNA/RNA damage that are indicative of oxidative damage. Weekly copper intake (10.1 to 80.2 mg) was negatively correlated with DNA/RNA damage (R2 = 0.44; P = 0.01). Weekly sodium intake (4.4 to 12.7 g) was positively correlated with GPx activity (R2 = 0.43; P = 0.04). More frequent feeding of whole prey (0.3 to 3 times/wk) was correlated with increased blood SOD activity (R2 = 0.55; P &lt; 0.01). In conclusion, greater dietary copper intake and more frequent feeding of whole prey may reduce OS in snow leopards. Dietary sodium intake and relationship with GPx activity should be further evaluated to determine benefit or detriment. No cause and effect can be inferred from our results, but our data suggest altering dietary form and nutrient concentrations may influence OS in snow leopards.
Fitness facility staff demonstrate high fidelity when implementing an evidence-based diabetes prevention program
Authors: Dineen Tineke E , Banser Tekarra , Bean Corliss , Jung Mary E 
Published: May 2021

AbstractTranslating evidence-based diabetes prevention programs into the community is needed to make promising interventions accessible to individuals at-risk of type 2 diabetes. To increase the likelihood of successful translation, implementation evaluations should be conducted to understand program outcomes and provide feedback for future scale-up sites. The purpose of this research was to examine the delivery of, and engagement with, an evidence-based diet and exercise diabetes prevention program when delivered by fitness facility staff within a community organization. Ten staff from a community organization were trained to deliver the diabetes prevention program. Between August 2019–March 2020, 26 clients enrolled in the program and were assigned to one of the ten staff. Three fidelity components were accessed. First, staff completed session-specific fidelity checklists (n = 156). Second, two audio-recorded counseling sessions from all clients underwent an independent coder fidelity check (n = 49). Third, staff recorded client goals on session-specific fidelity checklists and all goals were independently assessed for (a) staff goal-setting fidelity, (b) client intervention receipt, and (c) client goal enactment by two coders (n = 285). Average self-reported fidelity was 90% for all six sessions. Independent coder scores for both counseling sessions were 83% and 81%. Overall staff helped clients create goals in line with program content and had a goal achievement of 78%. The program was implemented with high fidelity by staff at a community organization and clients engaged with the program. Findings increase confidence that program effects are due to the intervention itself and provide feedback to refine implementation strategies to support future scale-up efforts.
Precision Health Diagnostic and Surveillance Network uses S Gene Target Failure (SGTF) combined with sequencing technologies to identify emerging SARS-CoV-2 variants
Authors: Guerrero-Preston Rafael , Rivera-Amill Vanessa , Caraballo Karem , García Andrea Arias , Sánchez Torres Raphael , Zamuner Fernando Tadeu , Zanettini Claudio , MacKay Matthew J. , Baits Rachet , Beaubier Nike , Khullar Gaurav , Metti Jessica , Pipic Una , Purcell-Wiltz Ana , Vale Keilyn , Pérez Gabriela , De Jesus Lorena , Miranda Yaima , Ortiz Denise , García Negrón Amanda , Viera Liliana , Ortiz Alberto , Acevedo Jorge , Romaguera Josefina , Jiménez-Velazquez Ivonne , Marchionni Luigi , Rodríguez-Orengo José , Baez Adriana , Mason Christopher E. , Sidransky David 
Published: May 2021

AbstractSeveral genomic epidemiology tools have been developed to track the public and population health impact of SARS-CoV-2 community spread worldwide. A SARS-CoV-2 Variant of Concern (VOC) B.1.1.7, known as 501Y.V1, which shows increased transmissibility, has rapidly become the dominant VOC in the United States (US). Our objective was to develop an evidenced-based genomic surveillance algorithm that combines RT-PCR and sequencing technologies to identify VOCs. Deidentified data were obtained from 508,969 patients tested for COVID-19 with the TaqPath COVID-19 RT-PCR Combo Kit (ThermoFisher) in four CLIA certified clinical laboratories in Puerto Rico (n=86,639) and in three CLIA certified clinical laboratories in the US (n=422,330). TaqPath data revealed a frequency of S Gene Target Failure (SGTF) >47% for the last week of March 2021, in both Puerto Rico and US laboratories. The monthly frequency of SGTF in Puerto Rico steadily increased exponentially from 4% in November 2020 to 47% in March 2021.The weekly SGTF rate in US samples was high (>8%) from late December to early January, and then also increased exponentially through April (48%). The exponential increase in SGFT prevalence in Puerto Rico is concurrent with a sharp increase in VOCs among all SARS-CoV-2 sequences from Puerto Rico uploaded to GISAID (n=461). B.1.1.7 frequency increased from <1% in the last week of January 2021 to 51.5% of viral sequences from Puerto Rico collected in the last week of March 2021. The exponential increase in SGTF and B.1.1.7 prevalence in Puerto Rico and US requires an urgent response. According to the proposed evidence-based algorithm, approximately 50% of all positive samples should be managed as potential B.1.1.7 carriers with VOC quarantine and contact tracing protocols while their lineage is confirmed by WGS in surveillance laboratories. Patients infected with VOCs should be effectively triaged for isolation, contact tracing and follow-up treatment purposes.