bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liebeskummer
Authors: Walter Henrik 
Published: December 2021

ZUSAMMENFASSUNGLiebeskummer, die emotionale Reaktion auf romantische Zurückweisung, ist ein normaler Bestandteil des Lebens und wird üblicherweise nicht als psychische Erkrankung verstanden. Dennoch kann er zu viel Leid führen und ist ein wichtiger Risikofaktor für Suizid bei Jugendlichen und im jungen Erwachsenenalter. In diesem Artikel wird der Liebeskummer genauer unter die psychiatrische Lupe genommen. Dabei werden seine Psychologie, Neurobiologie und Therapie dargestellt, die Frage gestellt, ob er mehr als eine Anpassungsstörung sein kann und sein soziologischer Kontext und seine Zukunft untersucht. Dem Liebeskummer, so das Fazit, sollte in Psychiatrie und Psychotherapie mehr Aufmerksamkeit geschenkt werden. Zudem kann er der psychiatrischen Forschung als Modell dienen, um Aspekte stressbezogener Erkrankungen wie Anpassungsstörungen, anhaltende Trauer, posttraumatische Belastungsstörungen, Depressionen und Sucht besser untersuchen und verstehen zu können.
Rape myths in practice: the everyday work of accounting for rape survivors
Authors: Brooker Phillip , Butler Catherine 
Published: December 2021

Abstract‘Rape mythologising’ has been found to be a reason why survivors of rape feel blamed, and might contribute to low rates of reporting or conviction. No research to date examines whether ‘rape mythologising’ occurs in the conversations of sexual health staff when discussing rape cases. Conversation Analysis was used to analyse a focus group conversation between five sexual healthcare clinic staff who routinely provided support to rape survivors, on the topic of three rape cases presented at the clinic. Three forms of conversation were noted in the focus group: (1) assessing ‘relatability’ in cases, (2) diagnostically reconstructing events and (3) apportioning blame to rapists. Implications for professional training are discussed. In all three, a tension was noted between drawing on rape myths and professional non-blaming discourses. This research demonstrates the need for further training of those who work with rape survivors.
The influence of transformational leadership and teachers’ trust in principals on teachers’ working commitment
Authors: Mansor Azlin Norhaini , Abdullah Rosnita , Jamaludin Khairul Azhar 
Published: December 2021

AbstractThe responsibilities of teachers and principals in Government Funded Religious Schools (GFRS) in Malaysia have become more demanding as the enrolment rates have risen over time. The principals’ transformational leadership (TL) potentially affects teachers’ trust (TT), which directly influences their work commitment (WC) in school. However, limited evidence is available to support this assertion. Thus, this study seeks to investigate: (a) the level of TL, TT, and WC and (b) the influence of TT as a mediator between TL and WC from the teachers’ perspective in the Government Funded Religious Schools (GFRS) in Selangor. This study employed a survey research design. A survey questionnaire was administered to 297 GFRS teachers in Selangor. These teachers were selected using a stratified random sampling technique. Descriptive (means, standard deviation, frequency, and percentage) and inferential statistics (analysis of regression and predictive accuracy) were employed to analyse the data. The findings suggested that the overall level TL (M = 4.077, SD = 0.533), TT (M = 4.070, SD = 0.521) and WC (M = 4.188, SD = 0.413) in GFRS in Selangor were ‘high’. It was also found that TL was a significant predictor of TT (B = 0.867, SE = 0.026, p < 0.05) and WC (B = 0.361, SE = 0.083, p < 0.05), with approximately 29% of the variance in WC accounted for by TL (R2 = 0.290). However, TT was not a significant predictor of WC (B = 0.064, SE = 0.085, p > 0.05), suggesting that TT did not mediate the relationship between TL and WC. Even though this study exemplified that the level of TL, TT and WC was at a high level, TT was found to have an insignificant effect on WC. This provides a new insight in understanding this complex relationship. The dynamic of relationships—among teachers, between teachers and staff, and with outside parties, might have an impact on developing TT and WC among these teachers.
Process expertise in policy advice: Designing collaboration in collaboration
Authors: Molinengo Giulia , Stasiak Dorota , Freeth Rebecca 
Published: December 2021

AbstractComplex societal and environmental challenges motivate scholars to assume new roles that transcend the boundaries of traditional academic expertise. The present article focuses on the specialised knowledge, skills, and practices mobilised in the context of science–policy interfaces by researchers who advise policymakers on collaborative governance processes intended to address these pressing issues. By working on the backstage of collaborative arrangements, researchers support policymakers in the co-design of tailor-made strategies for involving groups of institutional and non-institutional actors in collaboration on a specific issue. The present article examines the expertise underpinning this practice, which we termprocess expertise. While already quite widely practiced, process expertise has not yet been comprehensively theorised. The study employs a self-reflective case narrative to illuminate its constitutive elements and investigates the advisory work of the authors’ research team, called “Co-Creation and Contemporary Policy Advice”, located at the intersection of science, policymaking, and civil society. The findings show that process expertise, when exercised by researchers and supported by an assemblage of enabling conditions inherent to the research context, goes beyond the possession of a set of skills at the individual level. Instead, process expertise in the context of science–policy interfaces unfolds in interaction with other types of knowledge and fulfils its task by generating a weakly institutionalised “in-between space”, in which researchers and policymakers interact to find more inclusive ways of tackling complex challenges. In this realm, relational work contributes to establishing a collaborative modus operandi at the very outset of the advisory process, while working at the processual level supports knowledge co-production among multiple actors. The article argues that it is the ongoing work of process experts at the intersection of relational and processual levels that helps maintain momentum in these collaborative partnerships. By formulating and discussing five constitutive elements of process expertise, this paper untangles the complex work that is required in collaborative research settings and gives a language to the invisible work performed by researchers who offer policymakers—and other invited actors—advice on theprocessof designing collaborationincollaboration.
Effects of social economic status and parenting values on adolescents’ expected field of study
Authors: Keijer Micha G. 
Published: December 2021

AbstractField of study decisions are important for children’s future life chances, as significant differences exist in terms of financial and status benefits across fields of study. We examine whether the economic or the cultural status of the parents is more influential in shaping their children’s expectations about their future field of study. We also test whether children’s expectations about field of study choices are mediated by the child-rearing values that parents hold. Results show that parental economic status increased the likelihood of adolescents expecting to opt for extrinsic rewarding fields of study. Adolescent girls, not boys, with high cultural status parents were more likely to expect to opt for intrinsically rewarding fields of study. An upbringing that is characterized by conformity increased the expectations of boys to choose an extrinsically rewarding study, while self-direction increased the expectations of girls to opt for an extrinsic field of study
Quality of Evidence and Legal Decision-Making
Authors: Ganuza Juan José , Gomez Fernando , Penalva Jose 
Published: December 2021

Abstract
We analyze a setting where the court has to impose liability with imperfect evidence on the defendant’s actions, and where the court is concerned about both deterrence and judicial errors. We provide a formal definition of the quality of evidence that allows us to compare evidence from very different sources and of a very different nature in terms of informativeness. When imposing liability, the court’s optimal policy is to set an evidentiary standard. The main result of the article is that with a higher quality of evidence, more lenient evidentiary standards generate greater welfare. We also find that when the agent can influence the informativeness of the evidence the interests of court and agent are not aligned. The optimal court policy may involve penalizing (even forbidding) actions leading to less informative evidence.
On Dissonance and Its Functions in Asian American Criticism
Authors: Cruz Denise 
Published: December 2021

Abstract
Building upon recent work in Asian and Asian American studies, this essay explores dissonance, rather than disinterestedness, and its function and form for literary studies in our present time. It is inspired not only by my rereading of Matthew Arnold’s essay but also the convergence of key events over the course of the last few years, ranging from recent attention to Asian and Asian American cultural production to anti-Asian hate crimes. As an Asian Americanist, I research and teach in a field whose very emergence was tied to activist claims for institutional and disciplinary space. I therefore find it profoundly difficult to imagine our endeavors in American literary studies as “disinterested.” I am less invested in making the case whether or not the study of Asian American literature “matters”; rather, here I explore why Asian American literary studies—a method that seeks out and dwells in dissonance and urgency rather than disinterestedness and patience—might be a model worth continuing.
Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab
Authors: Ginthör Noemi E , Artinger Katharina , Pollheimer Marion J , Stradner Martin H , Eller Kathrin 
Published: December 2021

ABSTRACT
Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab.
Dizziness in an avid cyclist: an unusual presentation of a common problem
Authors: Sinha Aish , Demir Ozan M , Ellis Howard , Perera Divaka 
Published: December 2021

Abstract

Background
Presyncope and syncope are common presentations with a wide range of differential diagnoses; when it occurs primarily on exertion, a cardiovascular cause is more likely. Structural abnormalities and primary rhythm disturbances are the usual culprits in these patients.

Case summary
A 75-year-old gentleman presented with a history of progressive exertional presyncope. His investigations demonstrated normal cardiac structure, function, and rhythm. He underwent an exercise stress test, which demonstrated a significant reduction in peak blood pressure with equivocal electrocardiogram changes and absence of ischaemic symptoms. In view of his age and gender, a computerized tomography coronary angiogram (CTCA) was organized to exclude obstructive coronary artery disease (CAD). Intriguingly, the CTCA demonstrated a severe proximal left anterior descending (LAD) artery stenosis. This stenosis was confirmed to be functionally significant using invasive coronary physiology and was treated with percutaneous coronary intervention. At follow-up, there was no recurrence of exertional presyncope and the patient was continuing to return to his baseline function.

Conclusion
Presyncope and/or syncope as the sole manifestation of obstructive CAD, in the presence of normal ventricular function and valves, has rarely been reported. Myocardial ischaemia-mediated presyncope and/or syncope may be secondary to numerous mechanisms, which are described in this case report. Revascularization of the functionally significant proximal LAD stenosis resulted in cessation of exertional presyncope in our patient. The long-term outcome of revascularization in patients with presyncope and syncope needs to be further investigated.
Restating US Foreign Relations Law: Lessons from the Treaty Materials
Authors: Bradley Curtis A , Swaine Edward T 
Published: December 2021

Abstract
This short article responds to observations made by Alina Miron and Paolo Palchetti about the treaty sections of the Restatement of the Law (Fourth): The Foreign Relations Law of the United States. We describe the nature of the Restatement process and explain why the choices made in the Restatement (Fourth) were more constrained than what might be suggested by Miron and Palchetti’s critique. We also engage with some of their specific observations about the Restatement (Fourth)’s approach to treaties, resisting the suggestion that the approach marks a retreat from engagement with international law.
On The Robustness Of Respondent-Driven Sampling Estimators To Measurement Error
Authors: Fellows Ian E 
Published: December 2021

Abstract
Respondent-driven sampling (RDS) is a popular method of conducting surveys in hard to reach populations where strong assumptions are required in order to make valid statistical inferences. In this paper we investigate the assumption that network degrees are measured accurately by the RDS survey and find that there is likely significant measurement error present in typical studies. We prove that most RDS estimators remain consistent under an imperfect measurement model with little to no added bias, though the variance of the estimators does increase.
ET-1 Translational research platform for malignant brain tumors
Authors: Tateishi Kensuke , Miyake Yohei , Nakamura Taishi , Sasame Jo , Hayashi Takahiro , Oshima Akito , Honma Hirokuni , Ikegaya Naoki , Yamamoto Tetsuya 
Published: December 2021

Abstract
Introduction: The standard therapy for malignant brain tumors includes surgery and combination therapy with radiation and chemotherapy, but to provide individualized treatment based on the biological and molecular genetic background of the tumor, integrate genetic information with various functional data are required. In this study, we present an overview of our integrated approaches for translational research and clinical management. Methods: In glioma, pre-and intra-operative clinical information, including intraoperative genetic diagnosis, and intraoperative rapid immunohistochemistry is obtained, then a multidisciplinary treatment approach is started based on these integrated data. Specimens collected intraoperatively are cryopreserved for future analysis, and primary cultured cells are routinely collected. The cultured cells are transplanted into the brain of immunodeficient mice to establish patient-derived xenograft model (PDX). Genetic screening, such as IDH, TERT, BRAF, H3F3A mutation and MGMT methylation analysis are routinely assessed within a few days after surgery and used as information for integrated diagnosis. In case of PDX establishment or recurrence, we perform whole exon sequencing or comprehensive genomic assessment to identify genetic abnormalities. If genomic alterations for possible molecular targeted therapy are identified, we assess drug sensitivity test in vitro and in vivo, which are utilized for research to develop optimal molecular targeted therapy. The results, such as the therapeutic effects of molecular targeted drugs, are used for clinical applications. Results: Since the platform was established, we have treated a total of 286 patients, including 189 gliomas and 37 central nervous system lymphomas based on the integrated information. We are currently collecting clinical data to examine if this integrated approach could provide clinical benefit.Conclusion: The translational research system for malignant brain tumors plays an important role in the promotion of clinical and basic research.
ET-8 Integrated diagnostic approach to predict prognosis for malignant gliomas
Authors: Isoda Masataka , Tateishi Kensuke , Sasame Jo , Hayashi Takahiro , Miyake Youhei , Oshima Akito , Honma Hirokuni , Yamamoto Tetsuya 
Published: December 2021

Abstract
Previous studies indicated that MGMT promoter methylation status with IDH and TERT promotor mutation are major prognostic factors in glioma. In addition to these molecular features, we have been assessing drug sensitivity against several chemotherapeutic agents, including temozolomide (TMZ). Here, we examined if this combined information could strongly predict drug sensitivity and the prognosis in glioma patients. One hundred and twenty-five IDH wild-type gliomas (WHO grade III and grade IV) were included in this study and retrospectively analyzed. Among them, we focused on 37 patients with partial surgical resection and biopsy to assess radiological difference on MRI. The primary cultured tumor cells were exposed with several compounds for 72 hours, then ATP based cell viability assay was performed. The favorable radiological therapeutic effect was found in 6 out of 8 (75%) with MGMT promoter methylated cases, while unfavorable in 23 of 29 (79.3%) with MGMT promoter unmethylated cases (p=0.008). The drug screening assay demonstrated that 7 of 10 cases with favorable TMZ sensitivity in vitro showed response on MRI, whereas 22 of 27 (81.5%) cases with TMZ resistance in vitro indicated tumor progression (p=0.006). Of note, all 5 cases with sensitive to TMZ and methylated MGMT promoter demonstrated favorable radiological response (p=0.002). These 5 cases tended to survive longer (median survival time, 697 days) as compared to others (median survival time, 391 days, p=0.13). These data indicate that integrated approach with genomic assessment and drug screening test may predict therapeutic response to chemotherapy and contribute selecting optimal therapy in glioma patients.
TB-2 Patient-derived meningioma organoid model demonstrates FOXM1 dependent tumor proliferation
Authors: Yamazaki Shintaro , Ohka Fumiharu , Hirano Masaki , Shiraki Yukihiro , Motomura Kazuya , Tanahashi Kuniaki , Tsujiuchi Takashi , Motomura Ayako , Aoki Kosuke , Shinjo Keiko , Murofushi Yoshiteru , Kitano Yotaro , Maeda Sachi , Kato Akira , Shimizu Hiroyuki , Yamaguchi J Unya , Adilijiang Alimu , Wakabayashi Toshihiko , Saito Ryuta , Enomoto Atsushi , Kondo Yutaka , Natsume Atsushi 
Published: December 2021

Abstract
Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific molecular alterations have not yet been identified because of the limited number of representative research models of meningiomas.
We established 18 organoid models comprising of two malignant meningioma cells (HKBMM and IOMM-Lee), 10 benign meningiomas, four malignant meningiomas, and two solitary fibrous tumors (SFTs). Using immunohistochemistry and molecular analyses consisting of whole exome sequencing, RNA-seq, and DNA methylation analyses, we compared the histological findings and molecular profiling of organoid models with those of parental tumors. The organoids exhibited consistent histological features and molecular profiles with those of the parental tumors. Using a public database of meningioma, we identified that upregulated forkhead box M1 (FOXM1) was correlated with increased tumor proliferation. Overexpression of FOXM1 in benign meningioma organoids increased organoid proliferation; depletion of FOXM1 in malignant organoids decreased proliferation. Additionally, thiostrepton, a FOXM1 inhibitor combined with radiation therapy, significantly inhibited proliferation of malignant meningioma organoid models (P&lt;0.01).
An organoid model for meningioma enabled us to elucidate the tumor biology of meningioma along with potent treatment targets for meningioma.
TB-3 miR-33a depletion accelerate medulloblastoma generation and invasion
Authors: Mineharu Yohei , Matsui Yasuzumi , Oichi Yuki , Kamata Takahiko , Morimoto Takaaki , Nakao Tetsushi , Horie Takahiro , Ono Koh , Terada Yokinori , Tanji Masahiro , Arakawa Yoshiki , Miyamoto Susumu 
Published: December 2021

Abstract
Background and purposes: Lipid metabolism have been shown to be associated with tumorigenicity in various malignancies. The purpose of this study was to investigate the association of miR-33, a key regulator of lipid metabolism, in tumorigenicity and progression of medulloblastoma. Methods: Incidence of medulloblastoma and histopathological findings were compared between ptch1+/- mice and ptch1+/- miR-33a-/- mice. Tumors extracted from these mice were transplanted subcutaneously in nude mice (n=14 for ptch1+/-, n=19 for ptch1+/- miR-33a-/-) and in C57BL/6 mice (n=12 for each). Gene expression profile was compared between tumors from ptch1+/- mice and those from ptch1+/- miR-33a-/- mice. Results: Knockout of miR-33a in ptch1+/- transgenic mouse model increased the incidence of spontaneous generation of medulloblastoma from 34.5% to 84.0% (p&lt; 0.001) at 12 months. Histopathological analysis showed infiltrative tumor borders in ptch1+/- miR-33a-/- tumors as compared with ptch1+/- ones. Tumor formation was observed in 21.4% for ptch1+/- tumors and 68.4% for ptch1+/- miR-33a-/- tumors in nude mice (p= 0.008). It was observed in 0% and 16.7% in immune competent mice. RNA sequencing detected that SCD1 and SREBF1 was upregulated in tumors from miR-33a knockout mice. Discussion: Our results demonstrated that depletion of miR-33a accelerated medulloblastoma generation and invasion. miR-33a may also be important for immune evasion. SCD1, which is reported to play a role in tumor stem cell maintenance and metastasis, can be a potential therapeutic target for medulloblastoma.