bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-Level Mesoscale and Cloud-Scale Interactions Promoting Deep Convection Initiation
Authors: Marquis James N. , Varble Adam C. , Robinson Paul , Nelson T. Connor , Friedrich Katja 
Published: May 2021

AbstractData from scanning radars, radiosondes, and vertical profilers deployed during three field campaigns are analyzed to study interactions between cloud-scale updrafts associated with initiating deep moist convection and the surrounding environment. Three cases are analyzed in which the radar networks permitted dual-Doppler wind retrievals in clear air preceding and during the onset of surface precipitation. These observations capture the evolution of (i) the mesoscale and boundary layer flow, and (ii) low-level updrafts associated with deep moist convection initiation (CI) events yielding sustained or short-lived precipitating storms. The elimination of convective inhibition did not distinguish between sustained and unsustained CI events, though the vertical distribution of convective available potential energy may have played a role. The clearest signal differentiating the initiation of sustained versus unsustained precipitating deep convection was the depth of the low-level horizontal wind convergence associated with the mesoscale flow feature triggering CI, a sharp surface wind shift boundary, or orographic upslope flow. The depth of the boundary layer relative to the height of the LFC failed to be a consistent indicator of CI potential. Widths of the earliest detectable low-level updrafts associated with sustained precipitating deep convection were ~3–5 km, larger than updrafts associated with surrounding boundary layer turbulence (~1–3 km wide). It is hypothesized that updrafts of this larger size are important for initiating cells to survive the destructive effects of buoyancy dilution via entrainment.
Post-diagnosis young-onset dementia care in the National Disability Insurance Scheme
Authors: Cations Monica , Day Sally , Laver Kate , Withall Adrienne , Draper Brian 
Published: May 2021

Objective: Post-diagnosis service delivery for young-onset dementia (with onset prior to 65 years) recently moved to the disability system in an attempt to address systemic barriers to best practice in aged care. The objective of this study was to examine experiences and satisfaction with disability services so far among people with young-onset dementia and their care partners and identify strategies for service and system improvement. Methods: The 151 participating Australians living with young-onset dementia or providing informal care to a person with young-onset dementia were recruited via social media, advocacy bodies and specialist medical clinics. A cross-sectional online survey asked participants to provide a timeline of their interactions with the disability system so far and rate their satisfaction with the disability system, aged care and disability services. Results: Participants reported a mean age at symptom onset of 55 years. In all, 53% were diagnosed with Alzheimer’s disease and 25% were diagnosed with frontotemporal dementia. Sixty percent had received an approved plan from the National Disability Insurance Scheme, although 3% were rejected. More than 27% waited longer than 6 months to receive their plan, and half waited at least a month post-approval to access services. Less than 30% agreed that the National Disability Insurance Scheme understands dementia, and fewer than half felt that the process of accessing National Disability Insurance Scheme funding is easy and fast enough. Nonetheless, respondents remained overwhelmingly in favour of young-onset dementia services remaining in the disability system rather than in aged care. Conclusions: While people with young-onset dementia and their care partners strongly agree with their inclusion in the National Disability Insurance Scheme, a relatively low level of experience with dementia in the disability workforce and a lack of integration with the healthcare and aged care systems continue to create important barriers for accessing the services they need.
Exploring e-maturity in Italian local governments: empirical results from a three-step latent class analysis
Authors: Tangi Luca , Soncin Mara , Agasisti Tommaso , Noci Giuliano 
Published: May 2021

This article undertakes a quantitative and holistic approach to frame a model of e-maturity in local governments, defined as the extent to which technologies permeate public service delivery. Moreover, the study adds evidence on the performance associated with different levels of e-maturity. In so doing, we collect survey data from 814 Italian local governments and integrate it with secondary sources. We propose a new angle for assessing e-maturity at the local government level, where the novel approach is the categorisation of public services on the basis of their final users. The application of a latent class analysis shows that the level of e-maturity is quite limited among Italian local governments and that most of them tend to prioritise government-to-business rather than government-to-citizen services in their digitisation process. A high level of e-maturity is associated with greater effectiveness rather than efficiency. Points for practitioners • When assessing e-maturity, municipalities should treat differently Government to Citizen and Government to Business services. • Currently, municipalities are focused more on the digitization of Government to Business services. • Socio-economic and environmental factors have a partial effect on e-maturity. The size of the municipality and the income per capita are the most significant indicators. • E-maturity raises effectiveness without a clear effect on efficiency. Only when reaching a fully accomplished e-maturity a slight effect on municipalities' expenditures can be detected.
Relationship between Company Characteristics and HR Disclosure Level: Evidences from Indian Public Sector Companies
Authors: Aggarwal Kirti 
Published: May 2021

The main purpose of the study is to examine the effect of company characteristics on Human Resource (HR) disclosure practices of listed public sector companies in India. The present study has taken into consideration 71 Indian public sector companies listed on NSE-500 Index. To measure the level of voluntary disclosure of listed public sector companies in India, the Human Resource Disclosure Index (HRDI) is created. It consists of 90 items. The data of HR disclosure score are collected through content analysis of annual reports of selected sample companies. The study was conducted over a period from 2012–2013 to 2017–2018. The data are analysed through descriptive statistics, correlation, Ordinary Least Square (OLS) regression model and Kruskal–Wallis test. The results of the study demonstrate that market capitalization, ownership concentration, type of auditor, pages of an annual report and return on total assets significantly influence the HRDI of Indian public sector corporations. On the other hand, debt–equity ratio, net fixed assets, net sales, company age, EPS, return on equity, current ratio, profit after tax and listing status are insignificantly associated with HRDI of listed public sector companies in India. Further, it has been observed that the HR disclosure practices varied with various industrial sectors. The present study contributes to the existing studies. HRDI used in the study would be used by businesses as a yardstick to strengthen their HR disclosure in future. JEL Codes: M14, M41, M48, O15
Balloon occlusion as an adjunctive technique during sclerotherapy of Puig's classified advanced venous malformations
Authors: Sundararajan Sri Hari , Ranganathan Srirajkumar , Shellikeri Sphoorti , Srinivasan Abhay , Low David W , Pukenas Bryan , Hurst Robert , Cahill Anne Marie 
Published: May 2021

Objective Puig types 2 through 4 venous malformations (VMs) are challenging to treat with sclerotherapy given their robust systemic outflow. Endovenous balloon occlusion offers a means of temporarily occluding systemic venous outflow to allow for more complete sclerotherapy. This study reviews our experience of implementing this technique in patients with Puig advanced (types 2 through 4) VMs. Methods An IRB approved review of treated venous malformations from 2013–2016 revealed 10 patients fitting inclusion criteria. Patient demographics, pre-procedural imaging, intra-procedural technical parameters, and post-procedural follow-up outcomes were recorded. All patients underwent temporary balloon occlusion of a systemic or major draining vein during sclerotherapy. Embolic agents included n-butyl cyanoacrylate glue, sodium tetradecyl sulfate foam, and coils. Standard 5 French angioplasty balloons ranged from 4 to 8 mm diameter and 2 to 8 cm length depending on vessel requiring occlusion. All patients underwent minimum 3-year follow-up questionnaire administration re-assessing resolution of lesion symptomology and post-procedural quality of life (QoL) measures. Results Of the 10 VMs treated, 2 were Type 2, 6 were Type 3, and 2 were Type 4. More than one sclerotherapy session was required in 7/10 patients (mean: 2, range: 1–4). Most common sites of VM systemic drainage included subclavian, popliteal, internal/external jugular, and basilic veins. All patients had no indication for further sclerotherapy following adjunctive balloon occlusion. No non-target embolization or immediate post-procedural complications occurred. Follow-up questionnaires (mean interval: 3 years 6 months, range: 3 years–3 years 11 months) confirmed the persistence of embolization effects, improved QoL, and no additional sclerotherapy sessions for all patients in the cohort. Conclusions Endovenous balloon occlusion as an adjunct to sclerotherapy can be considered when treating patients with types 2–4 venous malformations. This technique lowers the risk of non-target systemic venous embolization, allowing for operator-driven deeper intralesional sclerosant penetration and subsequently maintained treatment efficacy.
Pelvic tilt impacts cup orientation on CT: how accurate is the gold standard?
Authors: Kaiser Moritz , Renkawitz Tobias , Benditz Achim , König Matthias , Thieme Max , Weber Markus 
Published: May 2021

Background Computed tomography (CT) is the gold standard for the accurate measurement of cup inclination and anteversion in total hip arthroplasty (THA). However, functional cup position strongly depends on the tilt of the pelvis and thus pelvic tilt in the supine position on the CT table harbors the risk of misinterpretation. Purpose To evaluate the influence of pelvic tilt on cup measurements in postoperative CT scans. Material and Methods This is a secondary outcome analysis of a prospective study. In 123 patients undergoing THA, anatomic cup inclination and anteversion as measured on postoperative 3D-CT scans were compared between: (i) the anterior pelvic plane (APP) resembling neutral pelvic tilt; and (ii) the coronal plane representing the standard planes on CT. Furthermore, the effect of the variation on cup positions within Lewinnek’s safe zone in relation to the applied reference plane was assessed. Results Mean pelvic tilt in supine position was –3.5° ± 5.6°. This resulted in a mean difference for anteversion between APP und coronal plane of 2.1° ± 3.7° and of 2.1° ± 1.9° for cup inclination, respectively. The change varied up to 20.2° for cup inclination and up 12.2° for cup anteversion. The overall conversion rate for inclination and/or anteversion regarding Lewinnek’s safe zone was high at 23.6% (29/123). Conclusion Pelvic tilt affects cup orientation on CT scans depending on the applied reference plane. Standard CT planes should be corrected regarding pelvic tilt before measurements to avoid errors in measurement.
Long noncoding RNA LINC01296 plays an oncogenic role in colorectal cancer by suppressing p15 expression
Authors: Xu Jianing , Zhang Zhehao , Shen Dong , Zhang Ting , Zhang Jinsong , De Wei 
Published: May 2021

Objective To examine the role of the long noncoding RNA LINC01296 in colorectal carcinoma (CRC) and to explore the underlying mechanism. Methods We detected LINC01296 expression levels in a cohort of 51 paired CRC and normal tissues. We also assessed the effects of LINC01296 on cell proliferation and apoptosis in CRC cells in vitro, and measured its effect on tumor growth in an in vivo mouse model. We identified the potential downstream targets of LINC01296 and assessed its regulatory effects. Results Expression levels of LINC01296 were elevated in 37/51 CRC tissues compared with the corresponding normal tissues and were significantly associated with tumor stage, lymph node metastasis, and distant metastasis. Knockdown of LINC01296 using antisense oligonucleotides inhibited cell proliferation and promoted apoptosis of colon cancer cells in vitro and inhibited tumor growth in vivo. Knockdown of LINC01296 also significantly increased the gene expression of p15 in colon cancer cells. LINC01296-specific suppression of p15 was validated by the interaction between enhancer of zeste homolog 2 and LINC01296. Conclusion Overexpression of LINC01296 suppressed the expression of p15 leading to CRC carcinogenesis. These findings may provide the basis for novel future CRC-targeted therapies.
Transhepatic hilar approach for Bismuth types III and IV perihilar cholangiocarcinoma with long-term outcomes
Authors: Xu Xinsen , Yang Linhua , Chen Wei , He Min 
Published: May 2021

Objective To compare the outcomes of the transhepatic hilar approach and conventional approach for surgical treatment of Bismuth types III and IV perihilar cholangiocarcinoma. Methods We retrospectively reviewed the medical records of 82 patients who underwent surgical resection of Bismuth types III and IV perihilar cholangiocarcinoma from 2008 to 2016. The transhepatic hilar approach and conventional approach was used in 36 (43.9%) and 46 (56.1%) patients, respectively. Postoperative complications and overall survival were compared between the two approaches. Results Similar clinical features were observed between the patients treated by the conventional approach and those treated by the transhepatic hilar approach. The transhepatic hilar approach was associated with less intraoperative bleeding and a lower percentage of Clavien grade 0 to II complications than the conventional approach. However, the transhepatic hilar approach was associated with a higher R0 resection rate and better overall survival. Multivariate analysis showed that using the transhepatic hilar approach, the Memorial Sloan-Kettering Cancer Center classification, and R0 resection were independent risk factors for patient survival. Conclusion The transhepatic hilar approach might be the better choice for surgical resection of Bismuth types III and IV perihilar cholangiocarcinoma because it is associated with lower mortality and improved survival.
Association between functional mitral regurgitation and recurrence of paroxysmal atrial fibrillation following catheter ablation: a prospective cohort study
Authors: Ke Fusheng , Huang Yinhui , Jin Zhexiu , Huang Lei , Xiong Qiang , Jia Fang , Chen Yu , Chen Gang 
Published: May 2021

Objective The present study aimed to investigate the effect of functional mitral regurgitation (FMR) on recurrence of paroxysmal atrial fibrillation (PAF) in patients undergoing radiofrequency catheter ablation. Methods This prospective cohort study comprised 107 patients with PAF. The patients were divided into the FMR and non-FMR groups. FMR was assessed by Doppler echocardiography before index ablation. All patients initially underwent circumferential pulmonary vein isolation (CPVI) and were followed up for 12 months after ablation. PAF, atrial tachycardia, or atrial flutter served as the endpoint indicator. Results The median duration of PAF was 24 (3–60) months. Binary logistic univariate and multivariate analyses showed that FMR was not a risk factor for recurrence of catheter ablation for PAF (hazard ratio=0.758, 95% confidence interval: 0.191–3.004; hazard ratio=0.665, 95% confidence interval: 0.134–3.300, respectively). Kaplan–Meier analysis showed no significant difference in the recurrence rate between the groups. Fifteen (15/107, 14%) cases of PAF were triggered by the pulmonary vein. Three (3/107, 2.8%) cases of PAF were triggered by the superior vena cava. Conclusions FMR is not an independent risk factor for predicting recurrence of catheter ablation for PAF. FMR does not affect patients undergoing radiofrequency catheter ablation for PAF.
Assessment of Skeletal Maturity and Postoperative Growth Disturbance After Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients: A Systematic Review
Authors: Fury Matthew S. , Paschos Nikolaos K. , Fabricant Peter D. ,   PLUTO Study Group, Anderson Christian N. , Busch Michael T. , Chambers Henry G. , Christino Melissa A. , Cordasco Frank A. , Edmonds Eric W. , Ganley Theodore J. , Green Daniel W. , Heyworth Benton E. , Lawrence J. Todd R. , Matava Matthew J. , Micheli Lyle J. , Milewski Matthew D. , Nepple Jeffrey J. , Parikh Shital N. , Pennock Andrew T. , Perkins Crystal A. , Saluan Paul M. , Shea Kevin G. , Wall Eric J. , Willimon Samuel C. , Kocher Mininder S. 
Published: May 2021

Background: Growth disturbance is an uncommon but potentially serious complication after anterior cruciate ligament (ACL) reconstruction in skeletally immature patients. Purpose: To describe how the pediatric ACL literature has assessed preoperative skeletal maturity and the amount of growth remaining and to comprehensively review the incidence, reporting, and monitoring of postoperative growth disturbance. Study Design: Systematic review; Level of evidence, 4. Methods: This review included studies reporting original research of clinical outcomes of skeletally immature patients after ACL reconstruction. Patient characteristics, surgical techniques, preoperative assessments of skeletal maturity or growth remaining, and postoperative assessments of growth disturbances were extracted. Results: A total of 100 studies met inclusion criteria. All studies reported chronological age, and 28 studies (28%) assessed skeletal age. A total of 44 studies (44%) used Tanner staging, and 12 studies (12%) obtained standing hip-to-ankle radiographs preoperatively. In total, 42 patients (2.1%) demonstrated a leg length discrepancy (LLD) >10 mm postoperatively, including 9 patients (0.5%) with LLD >20 mm; furthermore, 11 patients (0.6%) with LLD underwent growth modulation. Shortening was the most common deformity overall, but overgrowth was reported more frequently in patients who had undergone all-epiphyseal techniques. Most LLDs involved the femur (83%). A total of 26 patients (1.3%) demonstrated a postoperative angular deformity ≥5°, and 9 of these patients underwent growth modulation. The most common deformities were femoral valgus (41%), tibial recurvatum (33%), and tibial varus (22%). Although standing hip-to-ankle radiographs were the most common radiographic assessment of growth disturbance, most studies inadequately reported the clinical and radiographic methods of assessment for growth disturbance. Additionally, only 35% of studies explicitly followed patients to skeletal maturity. Conclusion: This systematic review described significant variability in the reporting and monitoring of growth-related complications after ACL reconstruction in skeletally immature patients. The incidence of LLD and angular deformity appeared to be low, but the quality of research was not comprehensive enough for accurate assessment. Registration: CRD42019136059 (PROSPERO)
Trauma-Informed Organizational Dynamics and Client Outcomes in Concurrent Disorder Treatment
Authors: Shier Micheal L. , Turpin Aaron 
Published: May 2021

Purpose: To test an empirical model of the effects of a trauma-informed organizational environment on service user outcomes in the context of concurrent disorder treatment. Methods: Service users ( n = 172) were surveyed while in treatment to determine the effects of trauma-informed organizational dynamics (i.e., safety, trust, choice, collaboration, and empowerment) on service user intrapersonal development outcomes (i.e., self-awareness, outlook, coping ability, self-worth, and self-determination) and improvements with concurrent disorder behaviors. After testing for validity and reliability of latent factors, data were analyzed using multivariate analysis. Results: As a concise analytical model, the trauma-informed organizational environment was found to significantly positively predict all service user intrapersonal outcomes as well as a reduction in concurrent disorder behaviors. Conclusions: This study informs developments in the design and implementation of trauma-informed practice frameworks for concurrent disorder treatment and emphasizes the importance of adapting organizational environments to support improved client outcomes.
Global changes to the chemotherapy service during the covid-19 pandemic
Authors: Chow Man-Chie , Chambers Pinkie , Singleton Georgina , Patel Jignesh , Cooper Silvie , Mythen Charlotte , Bautista-González Elysse , Chisnall Georgia , Djellouli Nehla , Thwaites Benjamin , Wong Ian CK , Vindrola-Padros Cecilia 
Published: May 2021

Purpose In response to the COVID-19 pandemic, changes to chemotherapy services were implemented as a means of managing imposed workload strains within health services and protecting patients from contracting COVID-19. Given the rapidly evolving nature of the pandemic many changes were rapidly adopted and were not substantiated by robust evidence. This study aimed to describe the changes adopted internationally to chemotherapy services, which may be used to guide future changes to treatment delivery. Methods A survey was developed to understand the impact of COVID-19 on the delivery of systemic anti-cancer therapies (SACT). It comprised 22 questions and examined the strategies implemented during the pandemic to prioritise and protect patients receiving SACT and the participants’ professional opinion of the strategies employed. The survey was available in English, Spanish and French and was distributed via professional bodies. Results 129 responses were obtained from healthcare professionals working across 17 different countries. 45% of institutions had to implement treatment prioritisation strategies and all hospitals implemented changes in the delivery of treatment, including: reduction in treatments (69%), using less immunosuppressive agents (50%), allowing treatment breaks (14%) and switching to oral therapies (45%). Virtual clinic visits were perceived by participants as the most effective strategy to protect patients. Conclusions The pandemic has forced chemotherapy healthcare professionals to adopt new ways of working by reducing health interactions. Many areas of research are needed following this period, including understanding patients’ perceptions of risks to treatment, utilisation of oral treatments and the impact of treatment breaks on cancer outcomes.