bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare Earth Electrolysis: key issues for measurement of greenhouse gases from oxide-fluoride systems
Authors: Fukurozaki Sandra Harumi , Landgraf Fernando José Gomes 
Published: October 2021

Abstract
Over the past decade, the reduction of greenhouse gases (GHG) has been recognized as one of the key factors for sustainable primary metal production, in which the rare earth (RE) industry can be affected both in terms of price and use by GHG reduction policies and non-tariff technical barriers. From environmental and economic standpoint, the perfluorocarbons (PFC) emissions generated in RE electrolysis during events known as anode effects (AE) are strong infrared-absorbing GHG and play an important role for RE metals process improvements. However, there is no standard methodology to account these GHG emissions from RE metal production industry and the assessment of the contribution of PFC emissions from different technologies to the global warming is urgently needed. This paper focuses on the analysis of PFC measurements from RE metal production in terms of GHG inventory and sustainable production. The state of art of RE fused oxide-fluoride electrolysis, particularly of neodymium electrolysis, provides the technical fundamentals for the evaluation of PFC emissions factors reported in scientific articles. Based on International Panel on Climate Change (IPCC) standard methods and US Environmental Protection Agency (EPA) and International Aluminium Institute (IAI) protocol applied to analogous industrial process, the analysis of key issues for estimate CF4 and C2F6 emission factors from electrolytic RE production indicates the additional refinements are necessary to optimize the accuracy of total PFC emission amount from each currently RE technology. Additionally, the selection of emission estimation technique (EET) or mix EET should be considered on case-by-case basis as to their purposes and suitability for a particular process and facility. Finally, this paper highlights the technological implications related to the PFC emissions measurements and trends towards to set goals and develop strategies for GHG mitigation.
Evaluating the Predictive Value of Fetal Doppler Indices and Neonatal Outcome in Late-onset Preeclampsia With Severe Features: a Cross-sectional Study in a Resource-limited Setting
Authors: Moawad Eman Mohamed Ibraheim , Tammam Amr Samir Fouad , Mosaad Maha Mohamed , Sayed Hadeer Mashaal El , Elaimy Adel Mohammed Atef Mohammed 
Published: October 2021

Abstract
Background: Preeclampsia constitutes a major health problem with substantial maternal and perinatal morbidity and mortality. The aim of this study was to detect the diagnostic efficacy of fetal Doppler in predicting adverse outcomes in severe late onset preeclampsia (LOP). Methods: A prospective study was conducted among childbearing women who presented with severe LOP and matched controls. Umbilical artery (UA) and middle cerebral artery (MCA) Doppler indices including pulsatility index (PI), resistance index (RI), systolic/diastolic ratio (S/D) and cerebroplacental ratio (CPR) were measured.Results: All UA indices were significantly higher in the case group compared to the controls (p < 0.001). UA PI and RI were significantly correlated with all neonatal adverse outcomes except cord pH status (p < 0.05). Abnormal CPR was the most sensitive index that positively correlated with intrauterine growth retardation (IUGR), low 5- minute Apgar score and neonatal intensive care unit admission (79 %, 72.8 % and 73.3 %, respectively). In the same context, Abnormal UA PI and RI represented the most specific tool for predicting IUGR, low 1- and 5- minutes Apgar score with positive predictive values were 52 %, 87 % and 57 %, respectively.Conclusion: In severe LOP, UA Doppler remains the preferential indicator for adverse birth outcomes with CPR is the best index that could be solely used for predicting such outcome.
Prevalence and Molecular Characterization of Novel Pathogenic Strains of Macrococcus Caseolyticus Isolated From External Wounds of Donkeys in Khartoum State –Sudan
Authors: Ali Dania , Allam Mushal , Altayb Hisham , Mursi Dalia , Abdalla M. A , Mohammed N. O , Khaier Mona A. M. , Salih Manal , Abusalab Sarah , Ahmed Abbas 
Published: October 2021

Abstract
A pathogenic strains of Macrococcus caseolyticus was isolated from wounds infection during investigation on donkeys in Khartoum State. Samples were collected from external wounds (head, abdomin, back and leg), during different seasons of the year. One isolate (124B) was identified using whole-genome sequence analysis. RAST software identified thirty-one virulent genes of disease and defense including methicillin resistant genes, TatR family and ANT(4’)-Ib. Plasmid rep22 wasidentified by PlasmidFindet-2.0 Server and a CRISPR. MILST-2.0 predicted many novel alleles. NCBI notated the genome as a novel strain of M.caseolyticus strain (DaniaSudan). The MLST-tree-V1 revealed that DaniaSudan and KM0211a strains were interrelated. Strain Daniasudan was resistant to ciprofloxacin, ceftazidime, erythromycin, oxacillin, clindamycin and kanamycin. The prevalence of the strain was 4.73%, with significant differences between collection seasons and locations of wounds. Mice modling showen bacteremia and many clinical (swelling, allergy, wounds and loss of hair). Enlarged, hyperemia, adhesions and abscesses were observed in many organs. This represents the first report of pathogenic strains of M.caseolyticus worldwide.
New Candidates for Furin Inhibition as Probable Treat for COVID-19: Docking Output
Authors: Dayer Mohammad Reza 
Published: October 2021

Abstract
Furin is a serine protease that takes part in the processing and activation of the host cell pre-proteins. The enzyme also plays an important role in the activation of several viruses like the newly emerging SARS-CoV-2 virus that causes COVID-19 disease with a high rate of virulence and mortality. Unlike viral enzymes, furin owns a constant sequence and active site characteristics and seems to be a better target for drug design for COVID-19 treatment. Considering furin active site as receptor and some approved drugs from different classes including antiviral, antibiotics, and anti protozoa/anti parasites with suspected beneficial effects on COVID-19, as ligands we have carried out docking experiments in HEX software to pickup those capable to bind furin active site with high affinity and suggest them as probable candidates for clinical trials assessments. Our docking experiments show that saquinavir, nelfinavir, and atazanavir with cumulative inhibitory effects of 2.52, 2.16, and 2.13, respectively seem to be the best candidates for furin inhibition even in severe cases of COVID-19 as adjuvant therapy, while clarithromycin, niclosamide, and erythromycin with cumulative inhibitory indices of 1.97, 1.90, and 1.84, respectively with lower side effects than antiviral drugs could be suggested as prophylaxes for the first stage of COVID-19 treatment.
Acute Hepatitis E Virus Superinfection Increases Mortality in Patients with Cirrhosis
Authors: Lee Sang Soo , Cho Jin-Kyu , Kim Hee Jin , Cha Ra Ri , Lee Jae Min , Kim Hyun Jin , Jung Woon Tae , Lee Ok-Jae , Choi Jung Woo , Son Ho Jin , Jeon Hankyu 
Published: October 2021

Abstract
Background: Although acute hepatitis E is not fatal in healthy individuals, it is unclear whether hepatitis E superinfection increases mortality in patients with pre-existing liver disease. Thus, we investigated the prognosis of patients with acute hepatitis E according to their cirrhosis diagnosis, and the prognosis according to the development of acute-on-chronic liver failure (ACLF) in patients with cirrhosis and chronic liver disease (CLD). Methods: This study included 74 consecutive patients who were diagnosed with acute viral hepatitis E between January 2007 and December 2019. Of them, 39 patients without CLD, 13 patients with non-cirrhotic CLD, and 22 patients with cirrhotic CLD were analyzed. Results: Among the 74 patients with HEV infection, 7 (9.5%) died within 180 days: 5 with underlying cirrhosis (71.4%) and 2 without cirrhosis (28.6%). The 180-day mortality was significant higher for patients with cirrhosis than for patients without cirrhosis (22.7% vs. 3.8%, P = 0.013). The age- and sex-adjusted proportional-hazard model revealed an approximately 8-fold increase in 180-day mortality risk in patients with cirrhosis compared to patients without cirrhosis. In addition, development of hepatitis E virus-related ACLF due to acute liver function deterioration in patients with pre-existing CLD or cirrhosis worsened the 180-day mortality rate. Conclusions: Our findings suggest that the acute hepatitis E mortality rate was low in heathy individuals but higher in patients with cirrhosis, and especially high in those with ACLF.
Time to Recovery and Determinants of Uncomplicated Severe Acute Malnutrition Among 6–59 Months Children From the Outpatient Therapeutic Feeding Program in North Shewa Zone of Oromia Region, Ethiopia. A Prospective Follow-Up Study.
Authors: Taye Amare Bekalu , Asebe Degemu Sahlu , Tadesse Addisu Walelign 
Published: October 2021

Abstract
Introduction: Community-based management of acute malnutrition is implementing in Ethiopia. But there is scarce information in our study set up regarding the time to recovery and its predictors of SAM among 6-59 months children, so this study aimed to assess the time to recovery and its predictors of uncomplicated SAM among 6-59children managed at the OTP in north Shewa zone, Ethiopia.Methods: A health post-based prospective follow-up study had conducted on 6-59months children from November 20/2020 – February 20/2021. A total of 423 children had included in the study. A structured interviewer-administered questionnaire had used. The median time to recovery had calculated using the Kaplan Meier (KM) curve. The predictors of time to recovery were determined using both bi-variable and multi-variable Cox regression models with a 95% confidence interval (CI). Finally, the variable that had a p-value < 0.05 in the multi-variable analysis was declared as the predictors of time to recovery. Proportional hazard assumption was checked graphically and using Schoenfeld residual test.Result: From the total 423 Children, 327 (77.3%) recovered. The median time to recovery was 42 + IQR of 14 days. Children from food secure households; AHR= 9.6 with 95% CI (8.1-18.5), mild food insecure; AHR= 6.5 with 95% CI (3.1, 13.8), moderate food insecure; AHR= 2.5 with 95% CI (1.2-5.3). Mothers who traveled less than 2 hours walking distance to the health post; AHR=2.6 with 95% CI (1.8-18.7). Children who received the correct dose of the RUTF AHR=1.6 with 95% CI (1.1-2.3), children who measured their weight weekly AHR= 1.5 with 95% CI (1.1-2.0), and children treated by health extension worker who took the Nutrition-related training AHR= 2.1 with 95% CI (1.0-4.5) were predictors of time to recovery. Conclusion and recommendation: The median time to recovery was within the acceptable range of the Ethiopian protocol for the management of uncomplicated SAM in the Outpatient setup. Household food security status, the distance between home and health posts, the correct dose of RUTF, weekly weight measurement per protocol, and HEWs nutrition-related training status were the significant predictors of time to recovery. It is advisable to improve the household food security status, and the Health extension worker's (HEWs) nutrition-related training.
Development and Validation of a Nomogram for Predicting Bladder Calculi Risk in Patients With Benign Prostatic Hyperplasia
Authors: Xie Euxu , Gu Xuelian , Ma Chen , Guo Li , Li Man , Du Yuefeng 
Published: October 2021

Abstract
Objective To develop and validate a nomogram for predicting bladder calculi risk in patients with benign prostatic hyperplasia (BPH).Methods A total of 368 patients who underwent transurethral resection of the prostate (TURP) and had histologically proven BPH from January 2018 to January 2021 were retrospectively collected. Eligible patients were randomly assigned to the training and validation datasets. Least absolute shrinkage and selection operator (LASSO) regression was used to select the optimal risk factors. A prediction model was established based on the selected characteristics. The performance of the nomogram was assessed by calibration plots and the area under the receiver operating characteristic curve (AUROC). Furthermore, decision curve analysis (DCA) was used to determine the net benefit rate of of the nomogram. Results Among 368 patients who met the inclusion criteria, older age, a history of diabetes and hyperuricemia, longer intravesical prostatic protrusion (IPP)and larger prostatic urethral angulation (PUA) were independent risk factors for bladder calculi in patients with BPH. These factors were used to develop a nomogram, which had a good identification ability in predicting the risk of bladder calculi in patients, with AUROCs of 0.911 (95% CI: 0.876–0.945) in the training set and 0.884 (95% CI: 0.820–0.948) in the validation set. The calibration plot showed that the model had good calibration. Moreover, DCA indicated that the model had a goodclinical benefit. Conclusion We developed and internally validated the first nomogram to date to help physicians assess the risk of bladder calculi in patients with BPH, which may help physicians improve individual interventions and make better clinical decisions.
Efficacy Comparison of Three Kinds of Distal Tibial Hemiepiphyseal Implants in the Treatment of Postoperative Ankle Valgus of Congenital Pseudarthrosis of the Tibia
Authors: Hu Xiongke , Li Anping , Liu Kun , Mei Haibo 
Published: October 2021

Abstract
Background: Congenital pseudarthrosis of the tibia is a complex and serious disease in orthopedics which often requires multiple operations for treatment. Postoperative ankle valgus deformity is easily seen after the operation of congenital pseudarthrosis of the tibia. The aim of this study is to retrospectively evaluate the safety of three different implants for treating postoperative ankle valgus after congenital pseudarthrosis of the tibia.Methods: A total of 41 patients with postoperative ankle valgus after congenital pseudarthrosis of the tibia from December 2010 to July 2019 were selected. Out of these 41 patients, 23 patients were treated with “U”-shaped tension screw, 10 patients were treated with hollow screw and 8 patients were treated with cortical bone screw. The evaluation index was tibiotalar angle. The general data, preoperative, postoperative and final follow-up imaging data were recorded, and the deformity correction rate and complications were compared. Results: all the patients were performed with postoperative follow-up visit for at least 12 months (31 months on average). In the “U”-shaped tension screw group, the preoperative tibiotalar angle was (74.8±4.8°), the tibiotalar angle was (85.8±4.5°) when the internal fixation was removed; in the hollow screw group, the average preoperative tibiotalar angle was (72.2±6.1°), the average tibiotalar angle was (88.4±5.1°) when the internal fixation was removed; in the cortical bone screw group, the average preoperative tibiotalar angle was (75.1±4.2°), the average tibiotalar angle was (88.4±5.1°) when the internal fixation was removed. The correction effect of the “U”-shaped tension screw group was better than that of the other two groups, but the difference was not significant (the correction rate of the “U”-shaped tension screw group was 0.71°/month, with that of in the hollow screw group and cortical bone screw group being 0.64°/month and 0.61°/month respectively, P＞0.05). One case of internal fixation complication was reported in the hollow screw group; two cases of missing correction effect were reported, one in cortical bone screw group and one in hollow screw group; and two cases showing symptom of wound pain were reported in the “U”-shaped screw group. Conclusion: Ankle valgus is a common postoperative complication of congenital tibial pseudarthrosis. Temporary hemiepiphyseal is an effective treatment for postoperative ankle valgus deformity of congenital pseudarthrosis of the tibia in children. Through comparison, the "U"-shaped tension screw provides relatively better orthopedic results and has a lower rate of internal fixation complications.
Comparing the Effectiveness of 3D Printing Technology in the Treatment of Clavicular Fracture between Surgeons with Different Experiences
Authors: Guo Jiang long , Li Hong yi , Zhao Kui , Zhang Meng , Ye Jing zhi , Chen Jun , xiao mengqiang , Liu Jing feng 
Published: October 2021

Abstract
Purpose

To comparethe effectiveness of the three-dimensional (3D) printing technology in the treatment of clavicularfracturebetween experienced and inexperienced orthopedic surgeons.
Methods

A total of 80 patients with clavicle fracture (from February 2017 to May 2021)were enrolled in our study. Patients were divided randomly into four groups: group A: Patients underwent low-dose CT scan and 3D models were printed before surgeries performed by inexperienced surgeons; group B: Standard-dose CT were taken and 3D models were printed before surgeries performed by experienced surgeons; group C and D: Standard-dose CT were taken in both groups, and the operations were performed differently by inexperienced (group C) and experienced (group D) surgeons. Operation time, blood loss, length of incision and number of intraoperative fluoroscopy were recorded.
Results

No statistically significant differences were found in age, gender, fracture site and fracture type (P value: 0.23–0.88).Group A showed shorter incision length and less intraoperative fluoroscopy times than group C and D (P value < 0.05). There were no significant differences in blood loss volume, incision length and number of intraoperative time between group A and group B (P value range: 0.11–0.28). The operation time of group A was no longer than that of group C and D (P value range: 0.11 and 0.24).
Conclusion

The surgical effectiveness of inexperienced surgeons who applied 3D printing technology before clavicular fracture operation were better than those of both inexperienced and experienced surgeons did not use preoperative 3D printing technology.
Using Mobile Phone Data to Understand the Demographic Characteristics and Behavioral Patterns of Park Visitors in a Megacity, Beijing, China
Authors: Wu Yihang , Zhao Wenhao , MA JIN , Yaxi Liu , Pei Tao , Liu Qiyuan , Qu Yajing 
Published: October 2021

Abstract
BackgroundUrban parks are important places that allow urban residents to experience nature but are also associated with the risk of exposure to contaminated soil. Local researches on demographic characteristics and population behavior patterns are the basis of soil exposure assessment. The objectives were to determine park visitors’ demographic characteristics and behavioral patterns. MethodsA total of 86 urban parks in Beijing were selected, and mobile phone data were used to quantify the park visits, identify the demographic characteristics of the visitors, and determine the visitors’ stay times. A Kruskal-Wallis test and kernel density estimation were used for difference analysis and to describe the spatial aggregation of visitors, respectively. A random forest model was used to analyze the factors influencing the visitors’ stay times.ResultsVisitor numbers at comprehensive parks and theme parks decreased significantly in winter, whereas seasonal variations in visitor numbers at community parks and country parks were small. Almost half of the visitors to Beijing’s urban parks were foreign visitors, who, unlike local visitors, preferred to visit parks located in the city’s center. Parks were mostly used by males and visitors aged 31–45. Most visitors stayed in the park for 1–2 h, and the distance from a given visitor’s home to the park was the most important factor affecting stay time, contributing 80.65% of the difference in stay time.ConclusionsThis study provides a quantitative analysis of the patterns relating to urban park use by different groups of people. Changes in behavior patterns of different groups of people should be considered when assessing soil exposure.
Genotypic Diversity and Antimicrobial Resistance of Escherichia Coli Isolated From Pigs in Hubei, China
Authors: Li Xiaoyue , Liu Zewen , Wang Ningning , Liu Wei , Gao Ting , Zhou Danna , Yang Keli , Guo Rui , Liang Wan , Bei Weicheng , Yuan Fangyan , Tian Yongxiang 
Published: October 2021

Abstract
BackgroundIntestinal infections with Escherichia coli (E. coli) are mostly occur in piglets between 1~10 days old, which major lead to diarrhea and edema in newborn piglets. These diseases caused by E. coli can increase mortality, morbidity and growth delay of piglets, which are responsible for economic losses. In this study was to investigate the prevalence of antibiotic resistance, transmission mechanisms, and molecular epidemiology of E. coli strains isolated from pig farms in Hubei province. Furthermore, clonal and genetic diversity of isolates were identified. ResultsA total of 29 E. coli isolates were obtained from fecal of weaned piglets from Hubei province. The E. coli isolates in different regions demonstrate different genetic diversity. Multilocus sequence typing (MLST) presented that ST165 was the common sequence type, accounting for 27.6% of all E. coli isolates, followed by ST744, ST1081, ST101 and ST10. All of the isolates were resistant to the tested antibiotics to vary degrees, and more than 80% of E. coli isolates presented high resistance rates to ampicillin, lincomycin, doxycycline, tetracycline, sulfaisoxazole and ampicillin. There was one E. coli strain that was resistant to the fifteen antimicrobial agents tested. Overall, most of the isolates were conferring resistance to 5-7 antimicrobial agents tested.ConclusionsOur study reported E. coli isolates with high antimicrobial resistance and explores the genetic diversity of E. coli isolated from swine-origin. From the results obtained it can be concluded that these isolates present high prevalent multi-drug resistance. These data provide a greater understanding of the genetic diversity and antimicrobial resistance of E. coli.
“Trying to Avoid Fentanyl and Other Dangerous Fakes”: A Thematic Analysis of Risk-Mitigating Strategies in Opioid Reddit Posts
Authors: Nguyen Jennifer , Gilbert Lauren R. , Shaw George 
Published: October 2021

Abstract
Background: The opioid crisis has fuelled dramatic increases in fatal drug overdoses, with illicitly manufactured fentanyl and fentanyl analogues driving the opioid-related overdose death rates among all groups. One way to address these overdose deaths is through increasing public awareness about opioid overdoses and encouraging people who use drugs to make safe choices about opioids. The ease, convenience, and privacy of social media sites provide an inside look into the world of opioid users. This study seeks to understand the nature and significance of Reddit discussions regarding opioid overdoses and safe choices. Methods: We systematically searched Reddit during the month of August (2019). We collected 4,844 posts, across 25 distinct r/opiates subreddit forums using the search terms “opioids,” “drugs,” and “fentanyl”. We then used qualitative thematic analysis methods to code 49 unique original posts. Results: The posts from these Reddit discussions provide insight into this online opioid community and how they are sharing and normalizing risk-mitigating strategies to avoid opioid-related overdoses through (1) recognizing the dangers and avoiding fentanyl; (2) knowing the signs and symptoms of opioid overdoses; and (3) having and using naloxone to treat opioid overdoses. Conclusions: These informal and social interactions provide insight into the complexity the opioid epidemic crisis and can inform future strategies and interventions to address the opioid crisis.