bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent Attitudes Toward Enhancing Cognition and Clinical Research Trials in Down Syndrome: A Mixed Methods Study
Authors: Christensen Kirsten M. , Hojlo Margaret , Milliken Anna , Baumer Nicole T. 
Published: February 2021

ABSTRACT:

Objective:
As understanding of the neurobiological basis of cognitive impairment in Down syndrome (DS) advances and new pharmaceutical interventions targeting neurodevelopment become available, an in-depth understanding of the family perspective is essential to inform research efforts. A mixed methods study was conducted with parents of individuals with DS to learn about attitudes toward pharmacological interventions to enhance cognition, participation in clinical research trials in DS, and the relationship between child/family-specific factors and parent attitudes.

Method:
Parents completed an online survey (N = 37) assessing family/child sociodemographic factors and to capture thoughts on cognitive enhancement and participation in clinical drug trials. A subset of interested parents participated in a follow-up phone interview (N = 21) or focus group (N = 3; 1 FG). Double-blind thematic analysis was used to analyze qualitative data.

Results:
Parents' attitudes toward improving cognition, reversing intellectual disability, and participation in clinical trials correlated with each other and were informed by specific parent and child factors (e.g., child attention-deficit hyperactivity disorder/behavioral diagnosis and parent education). Qualitative themes included advantages, disadvantages, and ethical implications of enhancing cognition. In addition, themes emerged regarding the need to understand the mechanism and potential side effects of experimental drugs, logistical factors relating to willingness to participate in clinical trials, and the evolution of parents' attitudes over time.

Conclusion:
The findings highlight the complexity of issues and implications of clinical trials for enhancing cognition in DS. Child-specific factors, logistical and safety considerations, and personal belief systems all inform parent attitudes and decision making. The findings reflect the importance of incorporating parent perspectives and values in research direction and design.
Exploring Links Between Prenatal Adversity and Adolescent Psychiatric Risk in a Canadian Population-Based Sample
Authors: Faltyn Mateusz , Savoy Calan , Krzeczkowski John E. , Ferro Mark A. , Colman Ian , Van Lieshout Ryan J. 
Published: February 2021

ABSTRACT:

Objective:
Adverse prenatal and postnatal exposures may have long-lasting effects on health and development. However, it remains unclear whether being exposed to a greater number of prenatal adversities affects mental health risk. The current study examined whether exposure to maternal health problems prenatally is associated with an increasing risk of psychiatric morbidity in adolescents.

Methods:
Using data from the 2014 Ontario Child Health Study (OCHS), we examined associations between a count of 7 prenatal risk factors (maternal hypertension, diabetes mellitus, bleeding during pregnancy, influenza, urinary tract infection, thyroid disease, and depression/anxiety) and adolescent psychiatric morbidity. Adolescents (N = 2219) aged 12 to 17 years were assessed using the Mini-International Neuropsychiatric Interview for Children and Adolescents.

Results:
Exposure to each additional prenatal adversity was correlated with increased odds of attention-deficit/hyperactivity disorder (odds ratio [OR] = 1.29, 95% confidence interval [CI] = 1.03–1.60), generalized anxiety disorder (OR = 1.27, 95% CI = 1.05–1.55), and social anxiety disorder (OR = 1.35, 95% CI = 1.01–1.80) after adjustment for confounding variables.

Conclusion:
Exposure to prenatal adversity in the form of maternal health problems was correlated with an increased risk of attention deficit hyperactivity disorder and anxiety disorders in adolescence. Future studies should further investigate the effects of antenatal environmental exposures on these associations to determine the potential value of close monitoring of those exposed to prenatal risks.
Genome Warehouse: A Public Repository Housing Genome-scale Data
Authors: Chen Meili , Ma Yingke , Wu Song , Zheng Xinchang , Kang Hongen , Sang Jian , Xu Xingjian , Hao Lili , Li Zhaohua , Gong Zheng , Xiao Jingfa , Zhang Zhang , Zhao Wenming , Bao Yiming 
Published: February 2021

AbstractThe Genome Warehouse (GWH) is a public repository housing genome assembly data for a wide range of species and delivering a series of web services for genome data submission, storage, release, and sharing. As one of the core resources in the National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB,https://bigd.big.ac.cn/), GWH accepts both full genome and partial genome (chloroplast, mitochondrion, and plasmid) sequences with different assembly levels, as well as an update of existing genome assemblies. For each assembly, GWH collects detailed genome-related metadata including biological project and sample, and genome assembly information, in addition to genome sequence and annotation. To archive high-quality genome sequences and annotations, GWH is equipped with a uniform and standardized procedure for quality control. Besides basic browse and search functionalities, all released genome sequences and annotations can be visualized with JBrowse. By December 2020, GWH has received 17,264 direct submissions covering a diversity of 949 species, and has released 3370 of them. Collectively, GWH serves as an important resource for genome-scale data management and provides free and publicly accessible data to support research activities throughout the world. GWH is publicly accessible athttps://bigd.big.ac.cn/gwh/.
Autonomous epithelial folding induced by an intracellular mechano–polarity feedback loop
Authors: Wen Fu-Lai , Kwan Chun Wai , Wang Yu-Chiun , Shibata Tatsuo 
Published: February 2021

AbstractEpithelial tissues form folded structures during embryonic development and organogenesis. Whereas substantial efforts have been devoted to identifying mechanical and biochemical mechanisms that induce folding, how they interact remains poorly understood. Here we propose a mechano–biochemical model for dorsal fold formation in the earlyDrosophilaembryo, an epithelial folding event induced by shifts of cell polarity. Based on experimentally observed apical domain homeostasis, we couple cell mechanics to polarity and find that mechanical changes following the initial polarity shifts alter cell geometry, which in turn influences the reaction-diffusion of polarity proteins, thus forming a feedback loop between mechanics and polarity. This model can induce spontaneous fold formationin silico, recapitulate polarity and shape changes observedin vivo, and confer robustness to tissue shape change against small fluctuations in mechanics and polarity. These findings reveal emergent properties of a developing epithelium under control of intracellular mechano–polarity coupling.
The impact of relational demography and communication apprehension on follower perceptions of leader–follower relationships in the hospitality industry
Authors: Jones-Carmack Joy , Criscione-Naylor Noel 
Published: February 2021

PurposeThe paper aims to clarify the multivariate effects of follower communication apprehension (CA) and demographic dissimilarity on follower perceptions of the leader–follower relationship quality (i.e. measured by leader–member exchange (LMX) theory). This study examined the possible mediating effects of follower CA on the relationship between demographic dissimilarity and LMX.Design/methodology/approachResearch was collected from self-report ratings of one member of the dyad; several proactive techniques were utilized to reduce common method variance in the development and administration of the survey instrument. In total, 260 (N = 260) full-time hospitality industry employees participated in the study.FindingsThe results of this study indicate demographic dissimilarity has minimal effect on LMX and CA. However, the results indicated that follower CA was negatively related to follower perceptions of LMX quality. In addition, the results indicated that tenure working with the supervisor was negatively related to follower CA and positively related to follower perceptions of LMX quality.Research limitations/implicationsResearch results may lack generalizability, and causality cannot be confirmed. Future studies utilizing longitudinal designs and/or data collected from each member of the dyad may provide support for current findings.Practical implicationsThis paper includes implications for understanding how situational characteristics influence follower CA and perceptions of LMX to encourage supervisors to increase communication with new subordinates, especially during the organizational acculturation process, thus reducing turnover. Furthermore, the significant relationship between age dissimilarity and CA offers practical implications for managing and celebrating generational differences in the workplace and bridging the gap between generations by maximizing communication between supervisors and subordinates. Communication is an essential consideration in the hospitality industry linked to creativity, relationship building and enhanced service experiences. Ultimately, this paper provides guidance for leaders to build sustainable, positive relationships with subordinates through more effective communication and build more inclusive service-based organizations.Originality/valueThis paper contributes to communication and leadership management practices by addressing four major problems: (1) limited research on situational characteristics that inhibit LMX quality, (2) limited research on communication variables as antecedents to LMX, (3) minimal research on the relationship between CA and LMX and (4) non-existent research on CA as a mediating variable in the relationship between demographic dissimilarity and LMX.
Impact of lean manufacturing: evidence from apparel industry in Bangladesh
Authors: Bashar Abul , Hasin Ahsan Akhtar , Adnan Ziaul Haq 
Published: February 2021

PurposeMany research findings demonstrate the benefits of lean manufacturing implementation. However, the impact of lean manufacturing on organizational performance in developing countries like Bangladesh remains unexplored. The purpose of this paper is to investigate the impact of lean manufacturing system (LMS) on the organizational performance of the apparel industry in Bangladesh.Design/methodology/approachEmpirical data were collected from 227 apparel manufacturing firms using a close-ended structured questionnaire. The causal relationships between the independent and dependent variables are examined by structural equation modeling using AMOS 20.0 software.FindingsThe results reveal significant evidence that the implementation of LMS has a direct impact on organizational performance in terms of operational and business performance.Practical implicationsThe findings of this study will create a substantial interest among the practitioners of the apparel industry to implement LMS. This study will also explore the opportunities to develop lean implementation framework and identify the benefits that will enhance the competitive advantages.Originality/valueThis paper explores the causal relationships and argues based on the empirical data in the context of the apparel industry in Bangladesh.
Learning online research skills in lower secondary school: long-term intervention effects, skill profiles and background factors
Authors: Alamettälä Tuulikki , Sormunen Eero 
Published: February 2021

Purpose
The purpose of this paper is to investigate the long-term development of online research skills among lower secondary school students and how various factors such as teaching interventions and students’ self-efficacy, attitudes, information and communication technology (ICT) activity and gender are associated with development.

Design/methodology/approach
Two intervention courses were implemented to improve online research skills among 7th-grade students. In the follow-up test in the 8th grade, students’ skills were measured in Web searching, critical evaluation of sources and argumentative use of Web information. Students’ self-efficacy beliefs in online research, their attitudes toward learning, behavioral intentions in online research and ICT activity were surveyed by questionnaires.

Findings
The main finding was that the effect observed immediately after the intervention in 7th grade did not last until the following year. A cluster analysis revealed six skill profiles characterizing strengths and weaknesses in students’ performance in the subtasks of online research and indicated that many students suffer from poor evaluation skills. Self-efficacy beliefs stood out as a student-related factor associated with the development of online research skills.

Originality/value
This study contributed to the pedagogy of online research skills. It indicates that small-scale interventions are not enough to enhance 7th-graders’ online research skills. Students need continuous practice in different contexts during their school years. It is important to support students’ self-efficacy to motivate them to develop their skills in all the subtasks of online research. This study also demonstrated the importance of follow-up studies in online research skills, as they have been rare thus far.
Exploration of COVID-19 impact on the dimensions of food safety and security: a perspective of societal issues with relief measures
Authors: Sharma Janpriy , Tyagi Mohit , Bhardwaj Arvind 
Published: February 2021

PurposeOutbreak of the COVID-19 pandemic has created the catastrophic situation, it has crippled all the economic activities and seized off the operations of food supply chain (FSC). Disrupted FSC escalated the societal concerns related to food safety and security. The purpose of this study is to consolidate various issues, exploring the perspectives associated with the agricultural practices, food industries and society concerns related with the FSC performance system dynamics amid of COVID-19 pandemic.Design/methodology/approachTo structure this work, a detailed research literature insight focussing on the key findings associated with the past disease outbreaks like influenza, avian flu, Ebola, bird flu, SARS, foot and mouth disease and ongoing phase of COVID-19, encompassing the perspective related with various agricultural and concerned supply chain practices is clustered. Furthermore, issues having relevancy with the notion of this work, sourced from platforms of print and electronic media have been incorporated to ground the reality associated with the impacts, for better visualisation of the perspectives.FindingsThis study outlays the key findings which are relevant with the past pandemic outbreaks from the core of the research literature. It details the impact of the current COVID-19 scenario on the various FSC operations, focussing on dimensions allied with the industry, economic and society concerns. For the same, to mitigate the effects, relief measures focussing on the short- and long-term perspectives have been incorporated. Steps ramped up by the Government of India (GOI) to safeguard masses from the threat of food security, accelerate pace of the FSC operations and upscale operating capacities of the industries and agriculture practices have incorporated.Research limitations/implicationsPresented work is persuaded amid of the COVID-19 lockdown restrictions hence it outlays the theoretical perspectives only. But, these perspectives portray the ongoing scenario's impacts, extending its implication to the people coming from the industry and academia background. This study can felicitate the government bodies to make them familiar with the various impacts which indented the FSCs, food industries and added woes to the society concerns.Originality/valueIndia is the second largest populated nation of the world, and outspread of the COVID-19 has capsized the FSCs and raised the various instances, making population vulnerable to the threats of food insecurity. This study encompasses effect of the FSC disruption by incorporating its effect on the food industries practices, societal issues and extending possible relief measures to restructure the FSC dynamics. As of now, study focussing on the Indian FSC concerns, detailing of impacts due to pandemic outbreak, relief measures to sail out of the hard times are not available.
Egyptian small and medium sized enterprises’ battle against COVID-19 pandemic: March–July 2020
Authors: Zaazou Zeinab Abbas , Salman Abdou Doaa 
Published: February 2021

PurposeThe impact of COVID-19 outbreak freeze economic actors and hold innovative startups. This triggered the researchers to investigate the effect of the pandemic on small- and medium-sized enterprises (SMEs) in Egypt and how do these start-ups deal on the whole with this serious situation.Design/methodology/approachThe research in hand used both qualitative and quantitative methods. It started first with semi-structured interview questions addressed to a number of participants, then a quantitative study took place, ending with conclusion and recommendations.FindingsThere is an agreement among all participants that entrepreneurs should always be flexible and seek for investments in innovation. However, there is a discrepancy among participants’ opinions regarding the measurements taken by the Egyptian Government post the pandemic outbreak.Research limitations/implicationsThe field study results and the exploratory research results would have come out more accurate if it was not confined only to geographical limitation (Cairo Governorate).Practical implicationsThe research in hand suggests that practical measurements should not only provide first aid to start-ups by alleviating the pressure caused by constrained cash flow but also consider long-term measures embedded in and supported by the wider entrepreneurial ecosystem to ensure start-ups rapid recovery and growth.Social implicationsSMEs attribute to social and economic change and have an impact on the local public and social services sector as a result of the business’s activities.Originality/valueThis study first illustrates the challenges entrepreneurs are facing because of the pandemic, then it presents how entrepreneurs are dealing with the effects of the crisis.
An applied approach to multi-criteria humanitarian supply chain planning for pandemic response
Authors: Malmir Behnam , Zobel Christopher W. 
Published: February 2021

PurposeWhen a large-scale outbreak such as the COVID-19 pandemic happens, organizations that are responsible for delivering relief may face a lack of both provisions and human resources. Governments are the primary source for the humanitarian supplies required during such a crisis; however, coordination with humanitarian NGOs in handling such pandemics is a vital form of public-private partnership (PPP). Aid organizations have to consider not only the total degree of demand satisfaction in such cases but also the obligation that relief goods such as medicine and foods should be distributed as equitably as possible within the affected areas (AAs).Design/methodology/approachGiven the challenges of acquiring real data associated with procuring relief items during the COVID-19 outbreak, a comprehensive simulation-based plan is used to generate 243 small, medium and large-sized problems with uncertain demand, and these problems are solved to optimality using GAMS. Finally, post-optimality analyses are conducted, and some useful managerial insights are presented.FindingsThe results imply that given a reasonable measure of deprivation costs, it can be important for managers to focus less on the logistical costs of delivering resources and more on the value associated with quickly and effectively reducing the overall suffering of the affected individuals. It is also important for managers to recognize that even though deprivation costs and transportation costs are both increasing as the time horizon increases, the actual growth rate of the deprivation costs decreases over time.Originality/valueIn this paper, a novel mathematical model is presented to minimize the total costs of delivering humanitarian aid for pandemic relief. With a focus on sustainability of operations, the model incorporates total transportation and delivery costs, the cost of utilizing the transportation fleet (transportation mode cost), and equity and deprivation costs. Taking social costs such as deprivation and equity costs into account, in addition to other important classic cost terms, enables managers to organize the best possible response when such outbreaks happen.
Factors affecting intention to adopt halal practices: case study of Indonesian small and medium enterprises
Authors: Silalahi Sahat Aditua Fandhitya , Fachrurazi Fachrurazi , Fahham Achmad Muchaddam 
Published: February 2021

Purpose
This study aims to investigate the effect of religiosity, government support, consumer demand, the expectation for higher revenue and competition intensity on Indonesian small and medium-sized enterprises’ (SMEs) intention to adopt halal practices.

Design/methodology/approach
This study used a quantitative approach and surveyed 228 SME owners through electronic media and direct contact. The study then applied the structural equation modeling to evaluate the relationship between constructs. This study also conducted some modifications on the hypotheses structured to obtain the best model.

Findings
This study found that religiosity, government support and expectation for higher revenue have positive and significant effects on SMEs’ intention to adopt halal practices; conversely, consumer demand and competition intensity do not have significant effects.

Originality/value
While in Indonesia, many studies have been conducted on consumers as subjects concerning halal awareness and they revealed a positive effect on the intention to consume the products, still, to the best of the authors’ knowledge, there are no studies targeting producers, especially SMEs, as the research subjects. This study had fulfilled some gaps on contributing factors that encourage the adoption of halal practices on the producers’ side, especially on SMEs. Therefore, this study provided insights into how to bridge the producers’ and consumers’ interests regarding halal fulfillment. The findings also provided input on the policy formulation at the early stage of halal policy implementation.
Halal tourism: exploring innovative marketing opportunities for entrepreneurs
Authors: Battour Mohamed , Salaheldeen Mohamed , Mady Khalid 
Published: February 2021

Purpose
The aim of this conceptual paper is to define Halal tourism based on the current practices and to explore the available innovative business opportunities in Halal travel industry that could be exploited by Halal entrepreneurs.

Design/methodology/approach
Critical assessment in Halal tourism literature is used to define Halal tourism and to link between Halal entrepreneurship and Halal tourism to explore innovative marketing opportunities for entrepreneurs.

Findings
New Halal tourism definition is suggested based on the current practices in this field. The paper also provided new prospects for Halal Entrepreneurs that could enable them to start new ventures in Halal tourism industry.

Originality/value
This study provides new theoretical and practical contribution in Halal tourism and Halal entrepreneurship. The findings could help tourism operators, Halal entrepreneurs to introduce Halal tourism products and services for catering Muslim traveler needs.