bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of factors related to carbohydrate intolerance II: OGTT glucose at 120 minutes (LB298)
Authors: Galvan E , Levers K , Coletta A , Dalton R , Jung Y , O'Connor A , Goodenough C , Simbo S , Seesselberg C , Bonin B , Koozehchian M , Sanchez B , Barringer N , Rasmussen C , Greenwood M , Kreider R 
Published: June 2021

The OGTT is a gold standard in assessing carbohydrate intolerance (CI) and insulin resistance. However, the test is costly and time consuming. This study examined whether responses to a carbohydrate intolerance survey (CI) could predict response to an OGTT. 108 women (31.6±13 yrs, 34.7±7% body fat, 25.3±4 kg/m2) donated fasting blood samples, completed a CI inventory, had body composition and health measures determined, and underwent a 75g, 2‐hr OGTT. Pearson product correlations were performed to determine which factors correlated with OGTT glucose at 120 minutes (G120). Results revealed significant correlations (p<0.05) in G120 (112±25 mg/dl) to glucose AUC (r=0.60), glucose AUMC (r=0.73), Cmax (r=0.34), fasting insulin (r=0.34), HOMA (r=0.37), height (r=‐0.33), resting HR (r=0.29), BMC (r=‐0.34), BMD (r=‐0.23), FFM (r=‐0.39), DEXA body fat (0.24), BIA body fat (r=0.22), and perceptions of being more than 25 lbs overweight (r=0.25). These findings indicate that OGTT G120 is positively correlated to OGTT glucose AUC, fasting insulin, and HOMA. Further, that shorter women who perceive themselves as more than 25 lbs overweight with a higher body fat and resting HR with lower FFM, BMC, and BMD were more related to G120 during a OGTT.Grant Funding Source: Supported by Curves International (Waco, TX)
Assessment of factors related to carbohydrate intolerance III: Fasting HOMA (LB300)
Authors: Dalton R , Levers K , Galvan E , Coletta A , Jung Y , O'Connor A , Goodenough C , Simbo S , Seesselberg C , Bonin B , Koozehchian M , Sanchez B , Barringer N , Rasmussen C , Greenwood M , Kreider R 
Published: June 2021

The fasting homeostatic model assessment (HOMA) is a gold standard in assessing insulin resistance. However, the test is costly and time consuming. This study examined whether responses to a carbohydrate intolerance survey (CI) correlate to HOMA, an OGTT, body composition and/or markers of health. 108 women (31.6±13 yrs, 34.7±7% body fat, 25.3±4 kg/m2) donated fasting blood samples, completed a CI inventory, had body composition and health measures determined, and underwent a 75g, 2‐hr OGTT. Pearson product correlations were performed to determine which factors correlated with HOMA. Results revealed significant correlations (p<0.05) in HOMA (1.51±1.1) to G120 (r=0.37), glucose AUC (r=0.30), glucose AUMC (r=0.32), Cmax (r=0.24), fasting insulin (r=0.99), G/I ratio (r=‐0.49), height (r=‐0.27), waist circumference (r=0.26), BMI (r=0.21), BMC (r=‐0.21), BMD (r=‐0.27), DEXA body fat (r=0.28), and BIA body fat (r=0.23). However, HOMA did not significantly correlate to any question on the CI or symptoms during the OGTT. Results indicate that HOMA is positively correlated to OGTT glucose values, fasting insulin, the G/I ratio, waist circumference, BMI, and %BF and negatively correlated with height, BMC, and BMD but not related to CI questionnaire items or CI symptoms during an OGTT. Grant Funding Source: Curves International, Inc. (Waco, TX)
An extensively hydrolyzed infant formula with a new emulsifier system is well tolerated in young infants (LB310)
Authors: Borschel Marlene , Baggs Geraldine 
Published: June 2021

Extensively hydrolyzed formulas have less physical stability than intact protein formulas. Ingredient(s) are needed to stabilize these formulas. The purpose of the study was to evaluate the tolerance of infants to casein hydrolysate formulas containing different carbohydrates (CHO) and emulsifiers.113 infants were enrolled at 0‐8 d of age and fed a hydrolysate formula (Similac® Expert Care Alimentum® powder, Abbott Nutrition, Columbus, OH [CF]) or a formula with different CHO sources and emulsifier (EF) until 28 d of age. A 3rd formula was studied but not reported here. CHO in CF was maltodextrin (MD) and sucrose with DATEM as the emulsifier. CHO in EF was MD, sucrose, and modified cornstarch with no DATEM. The primary variable was mean rank stool consistency (MRSC) from entry to 28 d. Intake and stool records were completed daily and feeding, stooling and formula satisfaction questionnaires were completed at exit.No significant differences were observed in MRSC, 2.28+0.09 for CF and 2.18+0.08 for EF (calculated as 1=watery, 2=loose/mushy, 3=soft, 4=formed, 5=hard). No differences in # of stools/d, percentage of stool consistencies/colors, incidence of spit‐up/vomiting, or adverse events were observed. Parents of CF infants reported significantly better formula odor than those of EF infants (p=0.0267).In conclusion, the results of the study support that EF was a safe and well tolerated feeding for young infants.Grant Funding Source: Supported by Abbott Nutrition, Abbott Laboratories
Does Mode of Feeding Influence Infant Behavior? (LB312)
Authors: Marriage Barbara , Baggs Geraldine 
Published: June 2021

Breastfeeding is the ideal feeding for infants but when formula is used it is not known whether mode of feeding influences behavior. The goal was to determine if behavior of formula‐fed (FF) and breast‐fed (BF) infants were similar.Infants were enrolled at 0‐8 days of age and exclusively fed a milk‐based formula or BF. Infant behavior was assessed by a validated questionnaire (IBQ) at 4 months of age. Only those IBQ questions (22 total) or dimensions (clusters of related questions) that satisfied at least 1 of 2 a priori criteria were considered equivalent.A total of 228 infants (114 FF, 114 BF) were included. IBQs were completed at a mean of 121 days of age. Responses of 4 questions met the equivalence criteria along with the Colic (5 questions) and Overall Behavior Dimensions (20 questions). The results were similar for FF infants (n=88) fed a slightly reduced energy formula compared to BF infants (n=90) In conclusion, infant behavior, as assessed by parents using an IBQ at 4 months of age suggests that behavior of infants was similar and not influenced by mode of feeding. FF and BF babies showed similarity in crying behavior, days in good mood, and happy and quiet when waking up.Grant Funding Source: Supported by Abbott Nutrition
The impact of vitamin D on disease activity in Crohn’s disease (CD) (LB330)
Authors: Alrefai Dania , Vatanparast Hassanali , Jones Jennifer , El‐matary Wael , Aljebreen Abdulrahman 
Published: June 2021

Background: The impact of vitamin D on disease activity among CD patients has been studied as a modulator for autoimmune system. Since higher levels of vitamin D may significantly decrease disease activity. However, little is known about the effect of high doses of vitamin D on disease activity among CD patients. Objectives: Our aims are to determine vitamin D status and disease activity among CD cases in Canada and Saudi Arabia, and evaluate the impact of higher doses of vitamin D compared to EAR on disease activity among CD patients. Methods: This pilot study is a double‐blind, randomized, control trial involving approximately 60 recent, active CD patients engaged in induction therapy. The sample size includes patients in Saskatoon, Saskatchewan, Canada (n=30) and Riyadh, Saudi Arabia (n=30). The patients have been divided into three groups to receive different oral doses of vitamin D including: 1: 400 IU/day (Control group, EAR level) 2: 2,000 IU/day 3: 10,000 IU/day. The study is expected to last between January and April 2014, with nine weeks duration of intervention. Data are collected at baseline (0), 9 weeks, and at 2 months follow‐up. Along with anthropometric measurements, participants undergo laboratory examinations such as, WBC, Hg, Hct, ferritin, vitamin D, hsCRP and submit fecal samples, fill out the health related quality of life, socio‐demographic and physical activity questionnaires. We assess their dietary intake at the baseline and week 9 using three 24‐hour dietary recalls. Results: Since vitamin D is utilized in autoimmune disease, we expect to see CD patients with active disease in high dose group will benefit the most from vitamin D supplementation.Grant Funding Source: Supported by the Saudi Arabian Cultural Bureau in Ottawa and University of Saskatchewan
The effects of parenteral arginine and aminoguanidine on oxidant‐antioxidant homeostasis of organs in rats with subacute peritonitis (LB339)
Authors: Lo Hui‐Chen , Lee Chien‐Hsing 
Published: June 2021

Evidence showed that total parenteral nutrition support and inflammatory diseases are closely related to oxidative stress. Our previous study demonstrated that parenteral arginine and aminoguanidine, a selective inhibitor of inducible nitric oxide synthase, may elevate circulating antioxidants and antioxidant enzyme activities. The aim of this study was to investigate the effects of arginine and aminoguanidine on oxidant‐antioxidant homeostasis in peritonitis‐affected organs, that is, the liver, lung, and kidneys. Male Wistar rats with cecal puncture‐induced subacute peritonitis were infused with conventional or arginine‐, aminoguanidine‐, or arginine plus aminoguanidine‐supplemented parenteral nutrition solutions for 7 days. Healthy, orally fed and sham‐operated, parenterally fed rats were included. The results showed that parenteral nutrition significantly decreased activities of glutathione peroxidase (GPx) and catalase in the liver and decreased thiol group, lipid peroxidation, and superoxide dismutase (SOD) activity in the lung. Subacute peritonitis with parenteral feeding significantly decreased glutathione and SOD and GPx activities in the liver and decreased oxidized glutathione in the lung. In rats with subacute peritonitis, parenteral arginine supplementation significantly increased glutathione levels in the liver and lung and SOD and GPx activities in the kidneys. Aminoguanidine supplementation significantly increased thiol groups, glutathione, and SOD activity in the liver and thiol groups and oxidized glutathione in the lung. Arginine plus aminoguanidine supplementation significantly increased oxidized glutathione in the lung. Taken together, parenteral arginine may have beneficial effects on oxidant‐antioxidant homeostasis in the liver, lung, and kidneys and aminoguanidine may improve peritonitis‐induced oxidative stress in the liver in rats with subacute peritonitis.Grant Funding Source: Supported by 103‐CCH‐IRP
Mistletoe (Cladocolea loniceroides) Fruit Extract on Viability of Breast Cancer Cell Cultures (LB366)
Authors: SERRANO MALDONADO MARIA JOSE , GARCIA GASCA TERESA , DAMIAN MATZUMURA PABLO , SORIANO SANTOS JORGE 
Published: June 2021

Mistletoe is a tree parasitic plant; its impact is rather negative causing great tree mortality and economic losses around the world. Cladocolea (C.) loniceroides, Mexican mistletoe represents a serious pest and it has not been studied until today. It was considered useless because of the pruning problem, however the authors found that aqueous fruit extract of C. loniceroides presents antioxidant activity. The aim of this research was to identify if the antioxidant aqueous extract of mistletoe fruit provokes cell death in various breast cancer cell cultures.Doses‐response curves were built to ZR75‐1, MCF7, MDA‐MB‐231 and MCF10A as negative control. LC50 were 91, 42, 45.6 and 198.6 µg gallic acid eq./mL, respectively after 48 h treatment. Mistletoe fruit extract induces cell death to breast cancer cultures; which are most sensitive (two times por ZR75‐1 and four times for MCF7, respectively) than noncancerous cell line and this effect may be possible by the presence of some phytochemicals with antioxidant activity.
Association of Body Composition and Vitamin D Levels with Cardiac Geometric Pattern in Rheumatoid Arthritis Patients. (LB374)
Authors: Azevedo Paula , Batista Andrea , Baccaro Antonio , Narimatsu Karina , Modesto Pamela , Albano Aline , Polegato Bertha , Pereira Elenize , Rocha Oswaldo , Gradella Luciana , Minicucci Marcos , Zornoff Leonardo , Zanati Silmeia , Okoshi Marina , Paiva Sergio 
Published: June 2021

Chronic inflammation presented in rheumatoid arthritis (RA) is associated with systemic manifestations, that include micronutrient deficiency, changes in body composition and cardiac morphofunctional alterations. The aim of this study is to evaluate the association of serum vitramin D and body composition with cardiac geometric pattern in patients with RA.Methods: 30 patients with RA were submitted to clinical, nutritional and biochemical evaluation. Bioimpedance analysis and dual‐energy X‐ray absorptiometry (DEXA) was performed to evaluate body composition. Transthoracic dopller‐ echocardiography was performed to evaluate left ventricle mass and relative wall thickness (RWT) in order to find cardiac geometry patterns. Patients were divided in Normal or abnormal pattern (concentric remodeling or concentric hypertrophy.) Results: The mean age was 53±9 years; 70% were woman, 43% presented with hypertension. All patients have been treated with methotrexate and a biological agent and presented with Disease activity Score (DAS28) 2,7±1,2. Serum vitamin D (ng/mL) was 30± 10,Body composition showed: BMI (kg/m2 ) 26±6, abdominal circumference (cm) 96±12, hand grip (kgf) 19±4,6 ; fat mass evaluated by DEXA (%) 33,8 ± 9,5 and by bioimpedance (%) 34,7±8,3; phase angle 6,6±0,6. Normal Cardiac geometric pattern was observed in 45%, concentric remodeling in 31% and concentric hypertrophy in 24%. Multiple logistic regression showed that hypertension and phase angle explain abnormalities in geometric pattern, even when adjusted by age, gender and hypertension. Vitamin D correlated with RWT, however it is not associated with geometric pattern. Conclusion: phase angle may be a potential marker of cardiac geometric pattern in patients with RA.Grant Funding Source: FAPESP: Fundação de Amparo à Pesquisa do Estado de São Paulo
A nutrition environment evaluation of grocery and convenience stores in low‐income communities using the Nutrition Environment Measurement Survey for Stores (NEMS‐S) (LB382)
Authors: Hemmingson Kailtyn , Leone Ryan , Remley Daniel , Zies Susan , Lindshield Erika , Kidd Tandalayo , Adhikari Koushik , Muturi Nancy , Kattelmann Kendra 
Published: June 2021

INTRO: As part of a 5‐year multi‐state adolescent obesity prevention project, the nutrition environments of grocery and convenience stores were assessed in selected low income communities in Kansas, South Dakota, and Ohio (KS, SD, and OH). One control and one intervention community was selected per state.METHODS: Grocery and convenience stores (n=23) were identified for audit using the validated Nutrition Environment Measurement Survey for Stores (NEMS‐S). NEMS‐S evaluates availability of healthful food, price of healthy versus unhealthy food, and quality of fresh produce. Standard NEMS‐S scoring methods were used; higher overall scores indicate greater quality and availability of healthy items as well as lower or equal prices of healthy compared to unhealthy items (range ‐9‐54). Stores that did not meet NEMS‐S parameters were excluded.RESULTS: Using non‐parametric testing, no significant differences were found between average NEMS‐S scores of control and intervention communities within or among states (p > 0.05). Scores ranged from 2‐41, combined average score for all states was 14.57 ± 12.52 (mean ± SD).CONCLUSIONS: Results indicate that the selected low‐income communities in KS, SD, and OH have limited availability to affordable, quality, healthful food in community stores.Grant Funding Source: Agriculture and Food Research Initiative (AFRI) grant #2012‐68001‐19619 from the USDA National Institute for Food and Agriculture
Antioxidative Effects of Each Fraction of Buckwheat Sprout Grown under Different Visible Light (LB388)
Authors: Kang Myunghwa , Kim Myojung , Kim EunSong , Jang MoonSik , Jung Uk‐Sun , Eom SeokHyun , Lee Bomo , Park Solp , Jo Chaewon 
Published: June 2021

Antioxidative Effects of Each Fraction of Buckwheat Sprout Grown under Different Visible Light 1) Myojung Kim, 1)EunSong Kim, 2)MoonSik, Jang, 2)Uk‐Sun Jung 3)SeokHyun Eom, 1)Bomo Lee, 1)Soip Park, 1)Chaewon Jo, 1)Myunghwa Kang 1) 3Department of Food Science & Nutrition/Institute of Basic Science, Hoseo University, Asan, Korea, Republic 2)Natural Solution Co., Ltd, Suwon, Korea, Republic 3) Department of Horticultural Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, Korea, Republic In this study, buckwheat sprouts were grown under blue light, red light, dark room and fluorescent light in plant company. Their were subjested to different drying processes as freeze drying and hot air drying. Each solvent fractions has studied total polyphenol acid contents, flavonoids contents, DPPH, ABTS radical scavenging activities, SOD‐liked activities, reducing power measurement and hydroxyl radical scavenging activity. Total phenolic acid contents were 3.07 ± 0.0355mg/ml in FDR(freeze drying red light) butanol fraction layer, 3.05mg/ml in FDR ethyl acetate layer and 2.93 ± 0.1000mg/ml in HDD(hot air dry dark light) ethyl acetate layer. DPPH scavenger activity were 84.15% in FDR butanol layer, 82.94% in HDF ethyl acetate layer and 81.09% in FDF(freeze drying white) butanol layer. SOD ‐like activity were 91.53 ± 0.4088mg/ml in HDF ethyl acetate layer, 91.29 ± 0.000mg/ml in HDD ethyl acetate layer and 88.55 ± 0.1665mg/ml in HDD chloroform layer. ABTS activity were FLB 94.14 ± 0.3872mg/ml, 93.98 ± 0.0877 mg / ml in HDR hexane layer and 93.98 ± 0.7896 mg / ml in FDF hexane layer. Total flavonoid content were 5.17 ± 0.2276% in butanol layer FDR, 4.82 ± 0.0710% in FDR ethyl acetate layer and 4.79 ± 0.1049% in HDB butanol layer, respectively.Grant Funding Source: No
Comparison of extract and flavonoid‐rich Fraction from mulberry on proliferation and lipid accumulation in 3T3‐L1 adipocytes (LB392)
Authors: Kim Gun‐Hee , Park Hee Sook 
Published: June 2021

This study was performed to investigated the effect of ethanol extracts and fraction of Morus alba L. on adipocyte differentiation in 3T3‐L1 cell. Obesity is major obstacle for improving health. Therefore, the therapeutic approach using natural plants has been proposed as a novel strategy for preventing obesity. Fruits of mulberry (Morus alba L.) belonging to the Moraceae family have been widely used for therapeutic purposes in Asian countries for centuries. Many study investigated that mulberry fruits can be used as a warming agent, as a remedy for dysentery, and as a tonic, sedative, laxative, odontalgic, anthelmintic, expectorant, and emetic. This study was performed to investigated the effect of ethanol extract and flavonoid‐rich fraction (A2) of Morus alba. on adipocyte differentiation in 3T3‐L1cell. The anti‐proliferation effects of ethanolic extracts and A2 fraction were measured by MTT assay. Cell viability of ehtanolic extract decreased but not A2 fraction during 72 hr in preadipocyte. For anti‐adipogenic effects of Morus alba, ethanolic extract and A2 fraction were examined Oil red O staining assay. Treatment of 3T3‐L1 cells with ethanolic extracts and A2 fraction decreased adipocyte differentiation in a dose‐dependent manner by 18.1% and 32.7% in 100 μg/ml, respectively. The results indicate that Morus alba L. is a possible candidate for regulating lipid accumulation in obesity.Grant Funding Source: This work was supported by Priority Research Centers Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(KNF‐2009‐0094017).
Oxidative stress is decreased with short‐term Protandim use when piperine is substituted for ashwagandha (LB399)
Authors: Scalzo Rebecca , Davis Janelle , Beals Joseph , Biela Laurie , Giordano Gregory , Paris Hunter , Miller Benjamin , Hamilton Karyn , Bell Christopher 
Published: June 2021

Ashwagandha is an active ingredient of Protandim, a commercially available, plant‐based nutraceutical that activates nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2). In some countries ashwagandha is considered medicinal and thus is subject to regulation. The purpose of this study was to evaluate the effect of Protandim without ashwagandha, and Protandim with piperine substituted for ashwagandha, on circulating markers of oxidative stress. 33 overweight/obese adults, aged 45‐69 years, were assigned to one of three 30‐day interventions comprising daily consumption of: placebo (PLAC: 719 mg maltodextrin), Protandim minus ashwagandha (P‐A: a blend of milk thistle extract, bacopa monnieri extract, green tea extract, turmeric powder, and maltodextrin), or Protandim with piperine substituted for ashwagandha (P+P). Compared with baseline, circulating plasma thiobarbituric acid reactive substances were unaffected by PLAC (n=13; 4.70±0.44 vs. 6.09±0.84 nmol/mL; mean±SE), or P‐A (n=7; 5.44±0.86 vs. 7.79±1.42 nmol/mL), but were decreased with P+P (n=13; 6.31±0.91 vs. 4.90±0.47 nmol/mL); P=0.02. Nrf2 activation may provide protection from chronic diseases associated with increased oxidative stress. These preliminary data suggest, in countries where ashwagandha is considered medicinal, piperine may be an acceptable substitute ingredient in the Nrf2 activator, Protandim.Grant Funding Source: Supported by LifeVantage
Thiamin intakes and status of Korean adults (LB401)
Authors: Choi Ji Young , Kim Young‐Nam , Kang Keum Jee , Cho Youn‐OK 
Published: June 2021

The purpose of this study was to determine thiamin intakes and status of Korean adults. Three consecutive 24‐hour recalls and urine samples were collected from 149 healthy adults (68 males and 81 females) living in Seoul and metropolitan area, Republic of Korea. The means age of the subjects (mean+/‐SD) was 36.9+/‐11.6 years and there was no significant difference by gender. The mean thiamin intakes were 1.29 mg/day and 0.67 mg/1000 kcal. Thiamin intake of males was significantly higher than that of females (P=<0.001), but there was no significant difference in the ratio of thiamin to energy intake by gender. The percentage contribution from plant foods in thiamin intakes was 63.1%. The Korean adults consuming less the Korean Estimated Average Requirements for thiamin was 10.7% of total subjects. Average urine thiamin concentration was 51.0+/‐50.5 μg/g creatinine. There was no significant difference in urine thiamin levels by gender. Approximately 35.6% of the subjects were thiamin deficient (urine thiamin <27 μg/g creatinine), and urine thiamin concentrations of 42.3% were 27‐<65 μg/g creatinine, which is representative of low riboflavin status. Therefore, some of these Korean adults were at risk of inadequate thiamin status. Korean adults may need to be encouraged to consume thiamin‐rich foods.Grant Funding Source: Supported by 2013 research fund of National Research Foundation of Korea (NRF‐2011‐0021273).