bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-management of social well-being in a cross-sectional study among community-dwelling older adults: The added value of digital participation
Authors: Scheffer Mariska MJ , Menting Juliane , Boeije Hennie R 
Published: October 2021

Abstract
Background
This study aimed to examine associations between self-management abilities and digital participation among community-dwelling older adults with chronic conditions in the Netherlands.

Methods
The study utilized a cross-sectional design. Community-dwelling older adults were sampled from a Dutch nationwide panel study performed in October and November of 2019. We selected all adults of 65 years and above who had one or more chronic diseases (n = 1,656). Self-management was measured by six abilities (e.g., investing in resources for long-term benefits and taking care of a variety of resources), whereas digital participation was estimated with the frequency of four social internet uses (e.g., using social network websites and calling digitally).

Results
When predicting self-management abilities from digital participation, hierarchical multiple regression analysis determined statistically significant and positive relationships, in particular for e-mailing (β = 0.21; p < .001) and meeting new people online (β = 0.07; p < .05). Correlation analyses showed that highest associations were found between internet usage and the self-management abilities ‘taking initiative’ (r = .23; p < .001) and ‘being self-efficacious’ (r = .21; p < .001). Moreover, the study confirmed that higher age (β = -0.13; p < .001) and increased severity of disability (β = -0.12; p < .01) negatively impact abilities for self-management.

Conclusions
These findings suggest that internet usage and self-management abilities are positively related in the older adult population. Further research should be undertaken to examine the links between self-management abilities and digital participation more closely.
COVID-19 hotspots through clusters analysis in France (may–October 2020): where should we track the virus to mitigate the spread?
Authors: Spaccaferri Guillaume , Calba Clémentine , Vilain Pascal , Garras Loïc , Durand Cécile , Pilorget Corinne , Atiki Nahida , Bernillon Pascale , Bosc Laëtitia , Fougère Erica , Hanon Jean-Baptiste , Henry Valérie , Huchet-Kervella Caroline , Martel Mélanie , Pontiès Valérie , Mouly Damien , Rolland du Roscoat Enguerrand , Le Vu Stéphane , Desenclos Jean-Claude , Laporte Anne ,   Regional MONIC group, Rolland Patrick 
Published: October 2021

Abstract
Background
In France, the lifting of the lockdown implemented to control the COVID-19 first wave in 2020 was followed by a reinforced contact-tracing (CT) strategy for the early detection of cases and transmission chains. We developed a reporting system of clusters defined as at least three COVID-19 cases, within seven days and belonging to the same community or having participated in the same gathering, whether they know each other or not. The aim of this study was to describe the typology and criticality of clusters reported between the two lockdowns in France to guide future action prioritisation.

Methods
In this study we describe the typology and criticality of COVID-19 clusters between the two lockdowns implemented in France (between May and end of October 2020). Clusters were registered in a national database named “MONIC” (MONItoring des Clusters), established in May 2020. This surveillance system identified the most affected communities in a timely manner. A level of criticality was defined for each cluster to take into consideration the risk of spreading within and outside the community of occurrence, and the health impact within the community. We compared the level of criticality according to the type of community in which the cluster occurred using Pearson’s chi-square tests.

Results
A total of 7236 clusters were reported over the study period, particularly in occupational environment (25.1%, n = 1813), elderly care structures (21.9%, n = 1586), and educational establishments (15.9%, n = 1154). We show a shift over time of the most affected communities in terms of number of clusters. Clusters reported in occupational environment and the personal sphere had increased during summer while clusters reported in educational environment increased after the start of the school year. This trend mirrors change of transmission pattern overtime according to social contacts. Among all reported clusters, 43.1% had a high level of criticality with significant differences between communities (p < 0.0001). A majority of clusters had a high level of criticality in elderly care structures (82.2%), in disability care centres (56.6%), and health care facilities (51.7%).

Conclusion
These results highlight the importance of targeting public health action based on timely sustained investigations, testing capacity and targeted awareness campaigns. The emergence of new SARS-CoV-2 variants strengthen these public health recommendations and the need for rapid and prioritise vaccination campaigns.
Gender differences in depressive symptoms of rural Chinese grandparents caring for grandchildren
Authors: Zhao Dantong , Zhou Zhongliang , Shen Chi , Ibrahim Sahardid , Zhao Yaxin , Cao Dan , Lai Sha 
Published: October 2021

Abstract
Background
Caring for grandchildren is regarded as one of the principle roles of middle- and old-aged adults, especially among rural Chinese grandparents. This study aims to examine the gender differences in depressive symptoms of rural Chinese grandparents caring for grandchildren, based on the gender differences in grandparental role engagement and the theories of role strain and role enhancement.

Methods
A total of 4833 rural citizens with one or more grandchildren were selected from the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2015. Grandchild care was measured by continuous variable (duration) and categorical variable (no care, low intensity, moderate intensity, high intensity). Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression Scale (CES-D). We used coarsened exact matching (CEM) to balance the covariates of caregivers and non-caregivers. Following CEM, 1975 non-caregivers and 2212 caregivers were identified (N = 4187). Multilevel linear regression was employed to examine the gender differences in depressive symptoms. We also tested for the moderating role of gender on the association between grandchild care and depressive symptoms.

Results
Grandmothers were more likely to provide grandchild care (54.42% vs 51.43%) at high intensity (61.46% vs 51.01%), with longer duration (39.24 h vs 33.15 h) than that given by grandfathers. Grandmothers suffered more from depressive symptoms than grandfathers, and such gap increased when grandparents were involved in high-intensity care. Grandmothers providing grandchild care, particularly at moderate intensity, were associated with fewer depressive symptoms (Coef. = − 0.087, 95%CI: − 0.163, − 0.010; Coef. = − 0.291, 95%CI: − 0.435, − 0.147), compared with non-caregivers. Grandmothers giving moderate intensity of grandchild care were also associated with fewer depressive symptoms (Coef. = − 0.171, 95% CI: − 0.313, − 0.029), compared with those with low-intensity care. However, such associations were not significant among grandfathers.

Conclusions
Our findings highlight the gender differences in depressive symptoms of rural Chinese grandparents caring for grandchildren. Grandparents should be encouraged to engage in grandchild care, but at moderate intensity. The health status of middle- and old-aged adults, particularly females, should be monitored closely. Humanistic care, preventive care and curative treatment strategies focusing on such populations should be developed and refined.
Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation
Authors: Zeng Dejun , Hu Zhengyang , Yi Yanjun , Valeria Besskaya , Shan Guangyao , Chen Zhencong , Zhan Cheng , Lin Miao , Lin Zongwu , Wang Qun 
Published: October 2021

Abstract
Background
Differences in genetics and microenvironment of LUAD patients with or without TP53 mutation were analyzed to illustrate the role of TP53 mutation within the carcinogenesis of LUAD, which will provide new concepts for the treatment of LUAD.

Methods

In this study, we used genetics and clinical info from the TCGA database, including somatic mutations data, RNA-seq, miRNA-seq, and clinical data. More than one bioinformatics tools were used to analyze the unique genomic pattern of TP53-related LUAD.

Results
According to TP53 gene mutation status, we divided the LUAD patients into two groups, including 265 in the mutant group (MU) and 295 in the wild-type group (WT). 787 significant somatic mutations were detected between the groups, including mutations in titin (TTN), type 2 ryanodine receptor (RYR2) and CUB and Sushi multiple domains 3(CSMD3), which were up-regulated in the MU. However, no significant survival difference was observed. At the RNA level, we obtained 923 significantly differentially expressed genes; in the MU, α-defensin 5(DEFA5), pregnancy-specific glycoprotein 5(PSG5) and neuropeptide Y(NPY) were the most up-regulated genes, glucose-6-phosphatase (G6PC), alpha-fetoprotein (AFP) and carry gametocidal (GC) were the most down-regulated genes. GSVA analysis revealed 30 significant pathways. Compared with the WT, the expression of 12 pathways in the mutant group was up-regulated, most of which pointed to cell division. There were significant differences in tumor immune infiltrating cells, such as Macrophages M1, T cells CD4 memory activated, Mast cells resting, and Dendritic cells resting. In terms of immune genes, a total of 35 immune-related genes were screened, of which VGF (VGF nerve growth factor inducible) and PGC (peroxisome proliferator-activated receptor gamma coactivator) were the most significant up-regulated and down-regulated genes, respectively. Research on the expression pattern of immunomodulators found that 9 immune checkpoint molecules and 6 immune costimulatory molecules were considerably wholly different between the two groups.

Conclusions
Taking the mutant group as a reference, LUAD patients in the mutant group had significant differences in somatic mutations, mRNA-seq, miRNA-seq, immune infiltration, and immunomodulators, indicating that TP53 mutation plays a crucial role in the occurrence and development of LUAD.
Factors associated with mortality in rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis
Authors: Qiu Meihua , Jiang Jing , Nian Xueyuan , Wang Yutie , Yu Pengfei , Song Jie , Zou Shenchun 
Published: October 2021

Abstract
Background
Interstitial lung disease (ILD) is a common and potentially life-threatening complication for rheumatoid arthritis (RA) patients. However, there is a lack of clear prognostic factors in rheumatoid arthritis-associated interstitial lung disease (RA-ILD) patients. The purpose of this study was to complete a systematic review and meta-analysis of the factors associated with mortality in RA-ILD patients.

Methods
Medline, EMBASE and the Cochrane Library were searched up to September 1, 2020. The Newcastle–Ottawa Scale (NOS) was applied to assess the methodological quality of the eligible studies. Study characteristics and magnitude of effect sizes were extracted. Then, pooled hazard ratios (HRs) with the corresponding 95% confidence intervals (CIs) and pooled risk ratios (RRs) with 95% CIs were calculated to assess the factors associated with mortality in RA-ILD.

Results
Twenty-three of 3463 articles were eligible, and ten factors associated with mortality for RA-ILD were evaluated in the meta-analysis. Older age (HRs = 1.04, 95% CI 1.03–1.05), male sex (HRs = 1.44, 95% CI 1.21–1.73), having a smoking history (HRs = 1.42, 95% CI 1.03–1.96), lower diffusing capacity of the lung for carbon monoxide (DLCO)% predicted (HRs = 0.98, 95% CI 0.97–1.00), forced vital capacity (FVC)% predicted (HRs = 0.99, 95% CI 0.98–1.00), composite physiological index (CPI) (HRs = 1.04, 95% CI 1.02–1.06), usual interstitial pneumonia (UIP) pattern on HRCT (HRs = 1.88, 95% CI 1.14–3.10 and RRs = 1.90, 95% CI 1.50–2.39), emphysema presence (HRs = 2.31, 95% CI 1.58–3.39), and acute exacerbation of ILD (HRs = 2.70, 95% CI 1.67–4.36) were associated with increased mortality in RA-ILD, whereas rheumatoid factor (RF) positive status was not associated.

Conclusions
Through this systematic review and meta-analysis, we found that older age, male sex, smoking history, higher CPI, lower DLCO% predicted, lower FVC% predicted, UIP pattern on HRCT, emphysema presence and acute exacerbation of ILD were associated with an increased risk of mortality in RA-ILD.
Lymph node metastasis pattern and significance of left gastric artery lymph node dissection in esophagectomy for esophageal cancers
Authors: Deng Xiu-Mei , Zhu Tian-Yu , Wang Guo-Jun , Gao Bu-Lang , Wang Jing-Tao , Li Rui-Xin , Zhang Yun-Fei , Ding Heng-Xuan 
Published: October 2021

Abstract
Purpose
To investigate the lymph node metastasis pattern and significance of dissection of the left gastric artery lymph nodes in radical en bloc esophagectomy for esophageal squamous carcinomas based on the lymphatic drainage pathway revealed by carbon nanoparticle labeling.

Materials and methods
Patients who underwent en bloc esophagectomy endoscopically were retrospectively enrolled. Carbon nanoparticles were injected in the submucosa of upper thoracic esophagus to label the relevant draining lymph nodes. The clinical data, lymph nodes dissected, surgical technique, and complications were analyzed.

Results
En bloc esophagectomy was successful in all 179 patients. Metastases to the left gastric artery lymph nodes were positive in 42 patients (23.5%) but negative in 137 (76.5%). The left gastric lymph nodes were labeled, whereas no celiac lymph nodes were labeled by carbon nanoparticles. A total of 4652 lymph nodes were resected, with 26 lymph nodes per patient. Seventy-three patients had lymph node metastasis (73/179). Seventeen patients had metastasis to the recurrent laryngeal nerve lymph nodes (9.5%). The metastasis rate of the lower thoracic esophageal cancer to the left gastric artery lymph nodes was 37.0%, significantly greater than that at the middle (15.4%) or upper (6.7%) thoracic segment. The lymph node metastasis rate was significantly (P < 0.05) increased with the length of the cancerous lesion, infiltration depth, and poor differentiation. Univariate analysis revealed that the metastasis rate to the left gastric artery lymph nodes was significantly (P < 0.05) associated with paraesophageal lymph node metastasis, para-cardial lymph metastasis, and TNM classification. Multivariate analysis indicated that cancer location (odds ratio 8.32, 95% confidence interval 2.12–32.24) was significantly (P < 0.05) associated with metastasis to the left gastric artery lymph nodes, with the cancer at the middle and lower thoracic segments significantly more than in the upper thoracic segment.

Conclusion
Certain patterns exist in lymph node metastasis of esophageal cancer, and in radical esophagectomy of esophageal cancers, dissection of the left gastric artery lymph nodes is necessary to prevent possible residual or metastasis of esophageal squamous carcinomas based on the lymphatic drainage pathway of esophageal carcinomas demonstrated by carbon nanoparticle labeling.
Recent advances in immunoassays and biosensors for mycotoxins detection in feedstuffs and foods
Authors: Li Runxian , Wen Yang , Wang Fenglai , He Pingli 
Published: October 2021

AbstractMycotoxins are secondary metabolites produced by fungus. Many mycotoxin species are highly toxic and are frequently found in cereals and feedstuffs. So, powerful detection methods are vital and effective ways to prevent feed contamination. Traditional detection methods can no longer meet the needs of massive, real-time, simple, and fast mycotoxin monitoring. Rapid detection methods based on advanced material and sensor technology are the future trend. In this review, we highlight recent progress of mycotoxin rapid detection strategies in feedstuffs and foods, especially for simultaneous multiplex mycotoxin determination. Immunoassays, biosensors, and the prominent roles of nanomaterials are introduced. The principles of different types of recognition and signal transduction are explained, and the merits and pitfalls of these methods are compared. Furthermore, limitations and challenges of existing rapid sensing strategies and perspectives of future research are discussed.
Seismic microzonation of a region with complex surficial geology based on different site classification approaches
Authors: Salsabili Mohammad , Saeidi Ali , Rouleau Alain , Nastev Miroslav 
Published: October 2021

AbstractA seismic microzonation study was conducted to refine the seismic hazard model for the city of Saguenay, Canada. The Quaternary geology underlying Saguenay shows complex glacial and post-glacial stratigraphy with a number of buried valleys filled with fluvioglacial and glaciomarine sediments. High impedance contrast between rock formations and surficial sediments is prone to seismic amplification. To evaluate their applicability, advantages and limitations in capturing the geological specificity of the study area, four site classification methods were applied: the current National Building Code of Canada (NBCC) and Eurocode 8, both mainly based on the average shear-wave velocity for the surficial sediments (VS,avg) and for the top 30 m (VS,30); a method based on the fundamental site period (T0); and a hybrid method based on the combination of VS,30, T0 and VS,avg. The study specifically aimed to evaluate the importance of the site classification parameters on the resulting microzonation maps. VS,30 is capable to present the geological and geotechnical site conditions, however, the results may be further improved by considering Vs,avg in shallow and T0 in thick layers of soil sediments as secondary parameters. The T0 method gives also satisfactory results with T0 showing a better correlation to Vs,30 than to Vs,avg. The versatile hybrid method may be challenging to apply in certain cases with its nine different site categories and parameters.
Person authentication based on eye-closed and visual stimulation using EEG signals
Authors: Yap Hui Yen , Choo Yun-Huoy , Mohd Yusoh Zeratul Izzah , Khoh Wee How 
Published: October 2021

AbstractThe study of Electroencephalogram (EEG)-based biometric has gained the attention of researchers due to the neurons’ unique electrical activity representation of an individual. However, the practical application of EEG-based biometrics is not currently widespread and there are some challenges to its implementation. Nowadays, the evaluation of a biometric system is user driven. Usability is one of the concerning issues that determine the success of the system. The basic elements of the usability of a biometric system are effectiveness, efficiency and user satisfaction. Apart from the mandatory consideration of the biometric system’s performance, users also need an easy-to-use and easy-to-learn authentication system. Thus, to satisfy these user requirements, this paper proposes a reasonable acquisition period and employs a consumer-grade EEG device to authenticate an individual to identify the performances of two acquisition protocols: eyes-closed (EC) and visual stimulation. A self-collected database of eight subjects was utilized in the analysis. The recording process was divided into two sessions, which were the morning and afternoon sessions. In each session, the subject was requested to perform two different tasks: EC and visual stimulation. The pairwise correlation of the preprocessed EEG signals of each electrode channel was determined and a feature vector was formed. Support vector machine (SVM) was then used for classification purposes. In the performance analysis, promising results were obtained, where EC protocol achieved an accuracy performance of 83.70–96.42% while visual stimulation protocol attained an accuracy performance of 87.64–99.06%. These results have demonstrated the feasibility and reliability of our acquisition protocols with consumer-grade EEG devices.
What has the COVID-19 pandemic taught us about conducting patient and public involvement remotely? Insights from a series of digital meeting observations
Authors: Lampa Elin , Sonnentheil Björn , Tökés Antónia , Warner Georgina 
Published: October 2021

Abstract
Background
During the COVID-19 pandemic many work tasks are being done remotely through digital meetings, including PPI in research. Yet, some PPI activities have been paused or cancelled altogether during the pandemic. In this commentary, we share our insights from observing digital meetings with researchers and public contributors, representing vulnerable groups. Additionally, we discuss how remote PPI activities can be understood and improved.

Main body
As part of a PPI evaluation project, live observations were conducted by two trained observers, using a semi‐structured observation protocol developed to objectively assess aspects of group dynamics in PPI research meetings with public contributors with experience of seeking refuge and parents facing economic hardship. This project’s data collection is ongoing and the insights in this commentary is based on the observers’ discussion. We discuss these insights through the lens of the Media Richness Theory, stating that the choice of media we communicate through should be guided by what kind of information we want to communicate to each other. The more complex the information is, the richer the media tool needs to be. For example, information in a text message is more easily misinterpreted than information given in person. This is because meeting in person gives us more information, for example through body language and tone of voice. Based on our experiences from observing digital research meetings, we give suggestions on how to improve digital meetings with public contributors. A few key points are: actively choosing which media to use; being prepared to guide contributors to the chosen media in a way that is suitable for them; and the increased importance of the person chairing the meeting to actively include all participants.

Conclusions
We reach the conclusion that digital meetings with public contributors is possible, but that researchers need to make a commitment and actively work to solve practical issues. Finally, the format and structure of digital meetings should be co-created together with public contributors.