bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reexamining the Potential to Classify Lava Flows From the Fractality of Their Margins
Authors: Schaefer E. I. , Hamilton C. W. , Neish C. D. , Sori M. M. , Bramson A. M. , Beard S. P. 
Published: March 2021

AbstractCan fractal analysis of a lava flow's margin enable classification of the lava's morphologic type (e.g., pāhoehoe)? Such classifications would provide insights into the rheology and dynamics of the flow when it was emplaced. The potential to classify lava flows from remotely‐sensed data would particularly benefit the analysis of flows that are inaccessible, including flows on other planetary bodies. The technique's current interpretive framework depends on three assumptions: (1) measured margin fractality is scale‐invariant; (2) morphologic types can be uniquely distinguished based on measured margin fractality; and (3) modification of margin fractality by topography, including substrate slope and confinement, would be minimal or independently recognizable. We critically evaluate these assumptions at meter scales (1–10 m) using 15 field‐collected flow margin intervals from a wide variety of morphologic types in Hawaiʻi, Iceland, and Idaho. Among the 12 margin intervals that satisfy the current framework's suitability criteria (e.g., geomorphic freshness, shallowly‐sloped substrates), we show that five exhibit notably scale‐dependent fractality and all five from lava types other than ‘a‘ā or pāhoehoe would be classified as one or both of those types at some scales. Additionally, an ‘a‘ā flow on a 15° slope (Mauna Ulu, Hawaiʻi) and a spiny pāhoehoe flow confined by a stream bank (Holuhraun, Iceland) exhibit significantly depressed fractalities but lack diagnostic signatures for these modifications. We therefore conclude that all three assumptions of the current framework are invalid at meter scales and propose a new framework to leverage the potential of the underlying fractal technique while acknowledging these complexities.
Bias Correction of Ocean Bottom Temperature and Salinity Simulations From a Regional Circulation Model Using Regression Kriging
Authors: Chang Jui‐Han , Hart Deborah R. , Munroe Daphne M. , Curchitser Enrique N. 
Published: March 2021

AbstractIt is well known that climate and circulation model simulation output are often systematically biased. However, existing bias correction methods typically ignore spatial autocorrelation of the biases and correct only the overall mean and variance, resulting in mismatched spatial variability between bias‐corrected simulations and observations. In this study, we propose using regression kriging (RK) to correct for biased spatial patterns and apply this method to Regional Ocean Modeling System (ROMS) simulated ocean bottom temperature and salinity for the Mid‐Atlantic Bight, USA. RK combines modeling non‐stationary trends using (generalized) regression with ordinary kriging (OK) of the regression residuals. We compared the performance of RK to a simpler OK method and a quantile mapping (QM) method often used for bias correction of such model output. These methods were evaluated using the Structural Similarity (SSIM) index that can simultaneously evaluate model accuracy, precision, and spatial similarities. Our results show that while both RK and QM can correct for overall biases of the mean and variation, only RK can effectively reduce the spatial‐temporal autocorrelation of the biases. The RK method was able to bias correct while preserving the spatial‐temporal trends of the ROMS simulated bottom temperature and salinity surfaces. The RK approach can easily be applied to any similar climate and circulation model simulation output. This study has profound implications for studies that use the output from such a model for fine‐scale mapping, habitat suitability modeling, species distribution modeling, or predicting the effects of climate change.
Influences of Recent Particle Formation on Southern Ocean Aerosol Variability and Low Cloud Properties
Authors: McCoy Isabel L. , Bretherton Christopher S. , Wood Robert , Twohy Cynthia H. , Gettelman Andrew , Bardeen Charles G. , Toohey Darin W. 
Published: March 2021

AbstractControls on pristine aerosol over the Southern Ocean (SO) are critical for constraining the strength of global aerosol indirect forcing. Observations of summertime SO clouds and aerosols in synoptically varied conditions during the 2018 SOCRATES aircraft campaign reveal novel mechanisms influencing pristine aerosol‐cloud interactions. The SO free troposphere (3–6 km) is characterized by widespread, frequent new particle formation events contributing to much larger concentrations (≥1,000 mg−1) of condensation nuclei (diameters > 0.01 μm) than in typical sub‐tropical regions. Synoptic‐scale uplift in warm conveyor belts and sub‐polar vortices lifts marine biogenic sulfur‐containing gases to free‐tropospheric environments favorable for generating Aitken‐mode aerosol particles (0.01–0.1 μm). Free‐tropospheric Aitken particles subside into the boundary layer, where they grow in size to dominate the sulfur‐based cloud condensation nuclei (CCN) driving SO cloud droplet number concentrations (Nd ∼ 60–100 cm−3). Evidence is presented for a hypothesized Aitken‐buffering mechanism which maintains persistently high summertime SONdagainst precipitation removal through CCN replenishment from activation and growth of boundary layer Aitken particles. Nudged hindcasts from the Community Atmosphere Model (CAM6) are found to underpredict Aitken and accumulation mode aerosols andNd, impacting summertime cloud brightness and aerosol‐cloud interactions and indicating incomplete representations of aerosol mechanisms associated with ocean biology.
Size‐Fraction‐Specific Stable Isotope Variations as a Framework for Interpreting Early Eocene Bulk Sediment Carbon Isotope Records
Authors: Bhattacharya Joyeeta , Yeung Laurence Y. , Cong Lin , Dickens Gerald R. , Sun Tao 
Published: March 2021

AbstractCarbon isotope (δ13C) records from marine sediments and sedimentary rocks have been extensively used in Cenozoic chemostratigraphy. The early Paleogene interval in particular has received exceptional attention because negative carbon isotope excursions (CIEs) documented in the sedimentary record, for example, at the Paleocene Eocene Thermal Maximum (PETM), ca ∼56 Ma, are believed to reflect significant global carbon cycle perturbations during the warmest interval of the Cenozoic era. However, while bulk carbonate δ13C values exhibit robust correlations across widely separated marine sedimentary basins, their absolute values and magnitude of CIEs vary spatially, especially over time intervals characterized by major deviations in global carbon cycling. Moreover, bulk carbonates in open‐marine environments are an ensemble of different components, each with a distinct isotope composition. Consequently, a comprehensive interpretation of the bulk‐δ13C record requires an understanding of co‐evolution of these components. In this study, we dissect sediments, from the late Paleocene‐early Eocene interval, at ODP Site 1209 (Shatsky Rise, Pacific Ocean) to investigate how a temporally varying bulk carbonate ensemble influences the overall carbon isotope record. A set of 45 samples were examined for δ13C and δ18O compositions, as bulk and individual size fractions. We find a significant increase in coarse‐fraction abundance across the PETM, driven by a changing community structure of calcifiers, modulating the size of the CIE at Site 1209 and thus making it distinct from those recorded at other open‐marine sites. These results highlight the importance of biogeography in the marine stable isotope record, especially when isotope excursions are driven by climate‐ and/or carbon cycle changes. In addition, community composition changes will alter the interpretation of weight percent coarse fraction as proxy for carbonate dissolution.
Study of the Impact of Past Extreme Solar Events on the Modern Air Traffic
Authors: Hubert G. , Aubry S. 
Published: March 2021

AbstractThe ancient solar energetic particle (SEP) events of 774/775 CE and 993/994 CE were characterized thanks to radionuclide productions stored in environmental archives as ice cores or tree rings. Primary cosmic ray spectra deduced from these cosmogenic isotope data indicate that the impact of these extreme SEP events would have been much more significant than any of the ones observed during the modern era. However, the impact of these should be studied more accurately in the framework of the ambient dose equivalent impacting aircrew and passengers in the air traffic context by considering physical parameters such as time profile or anisotropy properties. In this study, the impact that 774/775 CE and 993/994 CE past extreme SEP events could have had on modern air traffic is discussed. Possible event spectra for these ancient events are derived from the spectra ground‐level enhancement (GLE) 5 and GLE 69, which have been observed during the modern era and have been widely studied/characterized using measurements. The investigations include the impact of the SEP activity on ambient dose equivalent, including detailed analyses considering route, airplane characteristics (departure, arrival, continent, airplane type), and the time occurrence of the SEP event. Statistical analyses show that additional dose levels can reach values on the order of 70 mSv, which is absolutely significant considering the current air traffic recommendations. The orders of magnitude of the ambient dose equivalent induced during past extreme SEP events raises a number of issues, both for aircrews and for avionics hardware. This study demonstrates that simulations can be useful for the evaluation of risks in case of extreme SEP events.
Fill‐and‐Spill: A Process Description of Runoff Generation at the Scale of the Beholder
Authors: McDonnell Jeffrey J. , Spence Christopher , Karran Daniel J. , van Meerveld H. J. (Ilja) , Harman Ciaran J. 
Published: March 2021

AbstractDescriptions of runoff generation processes continue to grow, helping to reveal complexities and hydrologic behavior across a wide range of environments and scales. But to date, there has been little grouping of these process facts. Here, we discuss how the “fill‐and‐spill” concept can provide a framework to group event‐based runoff generation processes. The fill‐and‐spill concept describes where vertical and lateral additions of water to a landscape unit are placed into storage (the fill)—and only when this storage reaches a critical level (the spill), and other storages are filled and become connected, does a previously infeasible (but subsequently important) outflow pathway become activated. We show that fill‐and‐spill can be observed at a range of scales and propose that future fieldwork should first define the scale of interest and then evaluate what is filling‐and‐spilling at that scale. Such an approach may be helpful for those instrumenting and modeling new hillslopes or catchments because it provides a structured way to develop perceptual models for runoff generation and to group behaviors at different sites and scales.
Biophotonic sensors with integrated Si3N4-organic hybrid (SiNOH) lasers for point-of-care diagnostics
Authors: Kohler Daria , Schindler Gregor , Hahn Lothar , Milvich Johannes , Hofmann Andreas , Länge Kerstin , Freude Wolfgang , Koos Christian 
Published: March 2021

AbstractEarly and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection. Within this context, waveguide-(WG)-based optical biosensors on the silicon-nitride (Si3N4) platform represent a particularly promising option, offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range. However, while passive Si3N4-based photonic circuits lend themselves to highly scalable mass production, the integration of low-cost light sources remains a challenge. In this paper, we demonstrate optical biosensors that combine Si3N4 sensor circuits with hybrid on-chip organic lasers. These Si3N4-organic hybrid (SiNOH) lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light source. Fabrication of the devices is simple: The underlying Si3N4 WGs are structured in a single lithography step, and the organic gain medium is subsequently applied by dispensing, spin-coating, or ink-jet printing processes. A highly parallel read-out of the optical sensor signals is accomplished with a simple camera. In our proof-of-concept experiment, we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length (L-)-related sensitivity of S/L = 0.16 rad nM−1 mm−1. To our knowledge, this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light source. We expect that the versatility of the device concept, the simple operation principle, and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics.
Quantification of T cell clonality in human T cell leukaemia virus type-1 carriers can detect the development of adult T cell leukaemia early
Authors: Wolf Sonia N. , Haddow Jana , Greiller Claire , Taylor Graham P. , Cook Lucy B. M. , Rowan Aileen G. 
Published: March 2021

AbstractAdult T cell leukaemia/lymphoma (ATL) arises from clonally expanded T cells that are infected with human T cell leukaemia virus type-1 (HTLV-1). Here, we show that ATL can be detected early in HTLV-1-carriers through quantification of T-cell receptor (TCR)Vβ subunit diversity on T-cells infected with HTLV-1 (CD3+ CCR4+ CD26− T-cells) using an ‘oligoclonality index’ (OCI-flow). We established a reference range for OCI-flow by analysing peripheral blood mononuclear cells (PBMCs) from HTLV-1-carriers who had not developed ATL in a median of 10.5 years follow up (n = 38) and patients with ATL (n = 30). In the third cohort of HTLV-1-carriers with no history or clinical evidence of ATL (n = 106), 19% of high proviral load (PVL, ≥4 copies of HTLV-1/100 PBMCs) carriers had an OCI-flow in the ATL range, >0.770. Carriers with an OCI-flow >0.770 (n = 14) had higher lymphocyte counts and PVLs and were more likely to have a family history of ATL than carriers with OCI-flow ≤0.770. ATL subsequently developed in two of these 14 carriers but no carriers with OCI-flow ≤0.770 (p = 0.03, cumulative follow-up 129 person-years). This method can be used to identify a subset of high-PVL HTLV-1-carriers at increased risk of developing ATL who may benefit from intervention therapy, prior to the detection of disease.
E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition
Authors: Liu Pei-Yao , Chen Cheng-Cheung , Chin Chia-Ying , Liu Te-Jung , Tsai Wen-Chiuan , Chou Jian-Liang , Huang Chuan-Yu , Chen Yu-Guang , Chen Ying-Chuan 
Published: March 2021

AbstractIn obese adults, nonalcoholic fatty liver disease (NAFLD) is accompanied by multiple metabolic dysfunctions. Although upregulated hepatic fatty acid synthesis has been identified as a crucial mediator of NAFLD development, the underlying mechanisms are yet to be elucidated. In this study, we reported upregulated expression of gene related to anergy in lymphocytes (GRAIL) in the livers of humans and mice with hepatic steatosis. Grail ablation markedly alleviated the high-fat diet-induced hepatic fat accumulation and expression of genes related to the lipid metabolism, in vitro and in vivo. Conversely, overexpression of GRAIL exacerbated lipid accumulation and enhanced the expression of lipid metabolic genes in mice and liver cells. Our results demonstrated that Grail regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1. Thus, Grail poses as a significant molecular regulator in the development of NAFLD.
Interferometric control of magnon-induced nearly perfect absorption in cavity magnonics
Authors: Rao J. W. , Xu P. C. , Gui Y. S. , Wang Y. P. , Yang Y. , Yao Bimu , Dietrich J. , Bridges G. E. , Fan X. L. , Xue D. S. , Hu C.-M. 
Published: March 2021

AbstractThe perfect absorption of electromagnetic waves has promoted many applications, including photovoltaics, radar cloaking, and molecular detection. Unlike conventional methods of critical coupling that require asymmetric boundaries or coherent perfect absorption that require multiple coherent incident beams, here we demonstrate single-beam perfect absorption in an on-chip cavity magnonic device without breaking its boundary symmetry. By exploiting magnon-mediated interference between two internal channels, both reflection and transmission of our device can be suppressed to zero, resulting in magnon-induced nearly perfect absorption (MIPA). Such interference can be tuned by the strength and direction of an external magnetic field, thus showing versatile controllability. Furthermore, the same multi-channel interference responsible for MIPA also produces level attraction (LA)-like hybridization between a cavity magnon polariton mode and a cavity photon mode, demonstrating that LA-like hybridization can be surprisingly realized in a coherently coupled system.
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
Authors: Zheng Kai , Hu Fan , Zhou Yang , Zhang Juan , Zheng Jie , Lai Chuan , Xiong Wan , Cui Ke , Hu Ya-Zhuo , Han Zhi-Tao , Zhang Hong-Hong , Chen Jian-Guo , Man Heng-Ye , Liu Dan , Lu Youming , Zhu Ling-Qiang 
Published: March 2021

AbstractAberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer’s disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a mouse model of AD. miR-135a-5p levels are significantly reduced in excitatory hippocampal neurons of AD model mice. This decrease is tau dependent and mediated by Foxd3. Inhibition of miR-135a-5p leads to synaptic disorder and memory impairments. Furthermore, excess Rock2 levels caused by loss of miR-135a-5p plays an important role in the synaptic disorder of AD via phosphorylation of Ser726 on adducin 1 (Add1). Blocking the phosphorylation of Ser726 on Add1 with a membrane-permeable peptide effectively rescues the memory impairments in AD mice. Taken together, these findings demonstrate that synaptic-related miR-135a-5p mediates synaptic/memory deficits in AD via the Rock2/Add1 signaling pathway, illuminating a potential therapeutic strategy for AD.
Hospital load and increased COVID-19 related mortality in Israel
Authors: Rossman Hagai , Meir Tomer , Somer Jonathan , Shilo Smadar , Gutman Rom , Ben Arie Asaf , Segal Eran , Shalit Uri , Gorfine Malka 
Published: March 2021

AbstractThe spread of Coronavirus disease 19 (COVID-19) has led to many healthcare systems being overwhelmed by the rapid emergence of new cases. Here, we study the ramifications of hospital load due to COVID-19 morbidity on in-hospital mortality of patients with COVID-19 by analyzing records of all 22,636 COVID-19 patients hospitalized in Israel from mid-July 2020 to mid-January 2021. We show that even under moderately heavy patient load (>500 countrywide hospitalized severely-ill patients; the Israeli Ministry of Health defined 800 severely-ill patients as the maximum capacity allowing adequate treatment), in-hospital mortality rate of patients with COVID-19 significantly increased compared to periods of lower patient load (250–500 severely-ill patients): 14-day mortality rates were 22.1% (Standard Error 3.1%) higher (mid-September to mid-October) and 27.2% (Standard Error 3.3%) higher (mid-December to mid-January). We further show this higher mortality rate cannot be attributed to changes in the patient population during periods of heavier load.
A noninvasive fluorescence imaging-based platform measures 3D anisotropic extracellular diffusion
Authors: Chen Peng , Chen Xun , Hepfer R. Glenn , Damon Brooke J. , Shi Changcheng , Yao Jenny J. , Coombs Matthew C. , Kern Michael J. , Ye Tong , Yao Hai 
Published: March 2021

AbstractDiffusion is a major molecular transport mechanism in biological systems. Quantifying direction-dependent (i.e., anisotropic) diffusion is vitally important to depicting how the three-dimensional (3D) tissue structure and composition affect the biochemical environment, and thus define tissue functions. However, a tool for noninvasively measuring the 3D anisotropic extracellular diffusion of biorelevant molecules is not yet available. Here, we present light-sheet imaging-based Fourier transform fluorescence recovery after photobleaching (LiFT-FRAP), which noninvasively determines 3D diffusion tensors of various biomolecules with diffusivities up to 51 µm2 s−1, reaching the physiological diffusivity range in most biological systems. Using cornea as an example, LiFT-FRAP reveals fundamental limitations of current invasive two-dimensional diffusion measurements, which have drawn controversial conclusions on extracellular diffusion in healthy and clinically treated tissues. Moreover, LiFT-FRAP demonstrates that tissue structural or compositional changes caused by diseases or scaffold fabrication yield direction-dependent diffusion changes. These results demonstrate LiFT-FRAP as a powerful platform technology for studying disease mechanisms, advancing clinical outcomes, and improving tissue engineering.
Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection
Authors: Wang Xiaohui , Lin Xiang , Zheng Zihan , Lu Bingtai , Wang Jun , Tan Andy Hee-Meng , Zhao Meng , Loh Jia Tong , Ng Sze Wai , Chen Qian , Xiao Fan , Huang Enyu , Ko King-Hung , Huang Zhong , Li Jingyi , Kok Kin-Hang , Lu Gen , Liu Xiaohui , Lam Kong-Peng , Liu Wanli , Zhang Yuxia , Yuen Kwok-Yung , Mak Tak Wah , Lu Liwei 
Published: March 2021

AbstractInnate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung γδ T cells to produce interleukin 17 A (IL-17A) for early protection against H1N1 influenza infection. During infection, the lung γδ T cell pool is constantly supplemented by thymic output, with recent emigrants infiltrating into the lung parenchyma and airway to acquire tissue-resident feature. Single-cell studies identify IL-17A-producing γδ T (Tγδ17) cells with a phenotype of TCRγδhiCD3hiAQP3hiCXCR6hiin both infected mice and patients with pneumonia. Mechanistically, host cell-released lipids during viral infection are presented by lung infiltrating CD1d+B-1a cells to activate IL-17A production in γδ T cells via γδTCR-mediated IRF4-dependent transcription. Reduced IL-17A production in γδ T cells is detected in mice either lacking B-1a cells or with ablated CD1d in B cells. Our findings identify a local host-immune crosstalk and define important cellular and molecular mediators for early innate defense against lung viral infection.