bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Resection of Esophageal Granular Cell Tumors: A Single Center Experience
Authors: Liu Kaipeng , Zhou Yangyang , Zheng Qingfen , Liu Dan , Yang Huiyu , Liu Bingrong 
Published: August 2021

Abstract
Background: Granular cell tumors (GCTs) are rare tumors probably originating from neurogenic Schwann cells. The aim was to evaluate the safety and feasibility of endoscopic resection for esophageal GCTs. Methods: The study retrospectively analyzed patients with pathologically diagnosed esophageal GCTs in our center from February 2012 to December 2020. Clinicopathological characteristics, endoscopic features and clinical outcomes were collected and analyzed. Results: 12 males and 10 females were identified. Lesions were located in the upper, middle and lower esophagus in three, six and thirteen cases respectively. 14 lesions (63.6%) exhibited white-to-yellow discoloration. The mean maximum diameter of these lesions was 5.7±2.2 mm (range 2-11.6 mm). The most lesions (91%) were located in the mucosa or submucosa layer, and 2 lesions (9.0%) were in the muscularis propria layer. Endoscopic mucosal resection (n=17), endoscopic submucosal dissection (n=4) and endoscopic submucosal excavation (n=1) were performed. En bloc resection was achieved in 20 lesions (90.9%). The R0 resection was achieved in 20 lesions (90.9%). No patients experienced intraoperative perforation or delayed bleeding in the mean length of postoperative hospital stay of 4.2±2.1 days (range 1-9 days). All patients had no recurrence or metastasis during the mean follow-up period of 48.1±27.2 months (range 2-102 months). Conclusion: Endoscopic resection is safe and effective for management of esophageal GCTs. Clinically, the appropriate approach of endoscopic resection should be selected according to the origin and size of the lesion.
Endovascular Revascularization Strategies Using Catheter-Based Thrombectomy Versus Conventional Catheter-Directed Thrombolysis for Acute Limb Ischemia
Authors: Gong Maofeng , He Xu , Zhao Boxiang , Kong Jie , Gu Jianping , Chen Guoping 
Published: August 2021

Abstract
Background
Acute limb ischemia (ALI) is an important clinical event threatening both life and the affected limbs, but the optimal treatment for ALI remains undefined. The aim of this study was to compare the safety and effectiveness of thrombectomy approaches via either catheter-based thrombectomy (CBT) or catheter-directed thrombolysis (CDT).
Methods
A total of 98 patients (mean age 69.7 years, 60 male) who underwent endovascular intervention for ALI from January 2015 to August 2018 were included. Of these, 57 were treated with primary CBT via a large-bore catheter, an AngioJet catheter or Rotarex catheter, and/or underwent low-dose CDT, and 41 were treated with primary CDT. The safety and effectiveness of CBT compared to conventional CDT and other various endovascular techniques were evaluated.
Results
More Rutherford IIb patients were treated with primary CBT (68.4%) than CDT (26.8%; P < .001). Patients who underwent primary CBT achieved a higher technical success rate than those who underwent primary CDT in a shorter procedure time (P < .001), whereas 42.1% of patients who underwent CBT did not need adjunctive CDT. The duration and dosage of adjunctive CDT in the CBT group were significantly decreased compared with those in the primary CDT group (both P < .001), and the CBT group achieved a shorter in-hospital length of stay (P < .001). Subgroup analysis revealed that patients treated with AngioJet and Rotarex catheters achieved slightly lower dosages, shorter CDT durations and shorter in-hospital stay lengths than those treated with large-bore catheters (P > .05). Clinical success was estimated to be achieved in 98.2% of patients who underwent CBT, which is similar to the 97.6% estimated in those who underwent primary CDT (P = 1.000), and this finding was similar among the CBT subgroups. Patients who underwent primary CBT had slightly fewer complications than those who underwent primary CDT (P = .059), especially minor complications (P = .036). The freedom from amputation at 6 and 12 months for CBT and CDT was assessed (93.0% vs 90.2% respectively, P = .625; 89.5% vs 82.5%, respectively, P = .34,). Comparable limb salvage was found for different techniques of large bore catheters, AngioJet catheters and Rotarex catheters. The Kaplan-Meier table analysis also showed similar limb salvage rates between groups.
Conclusions
Endovascular treatment of ALI with the use of catheter-based therapies is a safe and effective modality with similar safety and clinical outcome to conventional CDT alone, and this treatment modality overcomes the common shortcomings of CDT alone. Different CBT techniques have comparable efficacy but different adverse event profiles.
SnoRNA ENST00000391318 Suppressed Endometrial Receptivity by Competitively Binding To miRNA-3928-5p To Regulate CDH11 in Women in a GnRH Antagonist Stimulation Protocol
Authors: Ji Xiaowei , Liu Suying , Wang Lin , Xu Jun , Zou Xutong , He Liying , Chen Wei , Liu Miao , Dong Xi 
Published: August 2021

Abstract
Background

To determine the small nucleolar RNA (snoRNA) expression profiles in the endometrium during the implantation phase and identify their potential biological functions.
Methods

We used RNA sequencing to analyze the expression changes of snoRNAs in the endometrium of women during the implantation phase of the natural cycle and in the GnRH antagonist stimulation protocol. The expression of snoRNA ENST00000391318 was manipulated in endometrial cells by lentivirus. CCK-8, clone formation, flow cytometry, scratch and Transwell assays were used to detect the effects of ENST00000391318 on the proliferation, apoptosis, migration and invasion of endometrial cells. RNA pulldown and luciferase reporter gene experiments were used to detect the binding of ENST00000391318 to miRNA.
Results

Endometrial SNORNA ENST00000391318 was upregulated in the GnRH antagonist stimulation protocol. SNORNA ENST00000391318 overexpression inhibited cell proliferation and the cell cycle in Ishikawa cells, and SNORNA ENST00000391318 knockdown promoted cell proliferation and the cell cycle in Ishikawa cells. SNORNA ENST00000391318 overexpression inhibited cell migration and invasion in Ishikawa cells. SNORNA ENST00000391318 inhibited the expression of endometrium receptivity factor. miRNA-3928-5p is a target of SNORNA ENST00000391318 in Ishikawa cells. SNORNA ENST00000391318 regulates the expression of CDH11 through interaction with miRNA-3928-5p in Ishikawa cells.
Conclusions

The ENST00000391318/miR-3928-5p/CDH11 signaling pathway can regulate the receptivity of the endometrium for patients in the GnRH antagonist stimulation protocol. SNORNA ENST00000391318 downregulates the function of miR-3928-5p through a ceRNA mechanism to upregulate the expression of CDH11. SNORNA ENST00000391318 downregulates the receptivity of the endometrium by upregulating the expression of CDH11.
Patient-Reported Outcomes of Upadacitinib Versus Abatacept in Patients with Rheumatoid Arthritis and an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drugs: 12-Week Results of a Phase 3 Trial
Authors: Bergman Martin , Tundia Namita , Martin Naomi , Suboticki Jessica L , Goldschmidt Debbie , Song Yan , Wright Grace C 
Published: August 2021

Abstract
Background In previous clinical trials, patients with active rheumatoid arthritis (RA) treated with upadacitinib (UPA) have improved patient-reported outcomes (PROs). This post hoc analysis of SELECT-CHOICE, a phase 3, double-blind, randomized clinical trial evaluated the impact of UPA vs abatacept (ABA) with background conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) on PROs in patients with RA who have inadequate response or intolerance to biologic DMARDs (bDMARD-IR).Methods: Patients in SELECT-CHOICE received UPA (oral 15 mg once daily) or ABA (intravenous). PROs evaluated included Patient Global Assessment of Disease Activity (PtGA) by visual analog scale (VAS), patient’s assessment of pain by VAS, Health Assessment Questionnaire Disability Index (HAQ-DI), duration and severity of morning stiffness, 36-Item Short Form Health Survey (SF-36), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Work Productivity and Activity Impairment (WPAI), and EQ-5D 5-Level (EQ-5D-5L) index score. Least squares mean (LSM) changes from baseline to week 12 were based on an analysis of covariance model. Proportions of patients reporting improvements ≥ minimal clinically important differences (MCID) were compared using chi-square tests.Results: Data from 612 patients were analyzed (UPA, n=303; ABA, n=309). Mean age was 56 years and mean disease duration was 12 years. Thirty-two percent received >1 bDMARD and 72% received concomitant methotrexate at baseline. At week 12, UPA treatment showed significantly greater improvements than ABA treatment in PtGA, pain, HAQ-DI, morning stiffness severity, EQ-5D-5L, WPAI activity impairment domain, and 3/8 SF-36 domains and physical component summary (PCS) scores (P<0.05). Significantly more UPA- vs ABA-treated patients reported improvements ≥ MCID in HAQ-DI (74% vs 64%) and SF-36 PCS (79% vs 66%) and 4/8 domain scores (P<0.05). The proportions of patients achieving MCID in the remaining PROs were similar between groups.Conclusions: In this study, treatment with UPA or ABA resulted in clinically meaningful improvements in PROs at week 12 in patients with active RA. UPA treatment elicited greater improvements in key domains of physical functioning, pain, and general health, and earlier improvements in HAQ-DI compared with ABA.Trial registration: NCT03086343, March 22, 2017
Tourism Demand Forecasting Using Stacking Ensemble Model With Adaptive Fuzzy Combiner
Authors: Cankurt Selcuk , Subasi Abdulhamit 
Published: August 2021

Abstract
Over the last decades, several soft computing techniques have been applied to tourism demand forecasting. Among these techniques, a neuro-fuzzy model, Adaptive neuro fuzzy inference system (ANFIS) has started to emerge. A conventional ANFIS model cannot deal with the large dimension of a dataset, and cannot work with our dataset, which is a composed of a 62 time-series, as well. This study attempts to develop an ensemble model by incorporating neural networks with ANFIS to deal with the large number of input variables for multivariate forecasting. Our proposed approach is a collaboration of two base learners, which are types of the neural network models and a meta-learner of ANFIS in the framework of the stacking ensemble. The results show that the stacking ensemble of ANFIS (meta-learner) and ANN models (base learners) outperforms its stand-alone counterparts of base learners. Numerical results indicate that the proposed ensemble model achieved a MAPE of 7.26% compared to its single-instance ANN models with MAPEs of 8.50% and 9.18% respectively. Finally, this study which is a novel application of the ensemble systems in the context of tourism demand forecasting has shown better results compared to those of the single expert systems based on the artificial neural networks.
LSH-GAN: in-silico generation of cells for small
sample high dimensional scRNA-seq data
Authors: Lall Snehalika , Ray Sumanta , Bandyopadhyay Sanghamitra 
Published: August 2021

Abstract
A fundamental problem of downstream analysis of scRNA-seq data is the unavailability of enough cell samples compare to the feature size. This is mostly due to the budgetary constraint of single cell experiments or simply because of the small number of available patient samples. Here, we present an improved version of generative adversarial network (GAN) called LSH-GAN to address this issue by producing new realistic cell samples. We update the training procedure of the generator of GAN using locality sensitive hashing which speeds up the sample generation, thus maintains the feasibility of applying the standard procedures of downstream analysis. LSH-GAN outperforms the benchmarks for realistic generation of quality cell samples. Experimental results show that generated samples of LSH-GAN improves the performance of the downstream analysis such as feature (gene) selection and cell clustering.
A Prefix Based Approach for Joint Doppler and Channel Estimation in Underwater Communication
Authors: Bhadouria Vijay Singh , Agrawal Monika , Kumar Ritesh 
Published: August 2021

Abstract
Developing a reliable and robust underwater acoustic communication system is a difficult task, due to the complicated nature of the underwater channel, non-stationary noise, and a number of other factors. Indeed, channel estimation or equalization presents numerous challenges in this non-stationary, highly Doppler, multipath environment; as a result, traditional equalizers and PLL-based methods have limited performance. Generally, communication over such time-varying channels is accomplished via packets that contain a prefix/preamble signal for training, a payload containing the actual data, and a silent period for proper alignment. The prefix signal must be designed properly because it is used to estimate the channel and also to determine the start of packet. This paper proposes a novel prefix signal based on the hyperbolic chirp signal, where its Doppler invariance properties enable the extraction of the entire packet even when Doppler and severe multipath are present. Additionally, this proposed prefix enables an efficient and accurate method for fully characterising an underwater channel. The proposed prefix signal is used to estimate the multipath delay and amplitude, and different Doppler scales. Extensive simulations using various channel models are used to determine the proposed method robustness and efficacy under a wide range of conditions. Additionally, the proposed algorithm has been validated on a real-world channel.
High-Speed Joining of Tubes To Panel Sheets Using Electro-Hydraulic Forming
Authors: Babalo Vahid , Hossein Mohammad Reza Mirza , Fazli Ali , Solanpour Mehdi 
Published: August 2021

Abstract
This study presents a new method for high-speed joining of the sheet to the end of a tube without the need for any additional processes. Joining of the AA3105 sheets to the AA1170 tube is carried out with a thickness of 0.5 mm. The process is performed using electro-hydraulic forming which is a local deformation of the tube and sheet. In this method, the mechanical force is transmitted by working media in a very short time. The shock wave accelerates the panel sheet towards the die and tube to create a form-fit joint. To avoid friction between the mandrel and the flat sheet, the panel sheet is pre-drilled. The experimental tests were performed to show the effect of process parameters including; washer housing angle, sheet hole diameter, and the gap between the mandrel and top of the sheet. In addition, pull-out test is utilized to determine the strength of the joints in different conditions. Accordingly, the usage of electro-hydraulic forming on joining thin tubular parts to flat sheets was successful and the feasibility of this technique as an advanced joining approach was verified.
Ranking based RPL for Multipoint-to-Point Multi-modal Data Communication in IoT Network.
Authors: Bhat Archana , V Geetha 
Published: August 2021

Abstract
IPv6 Routing Protocol for low power and lossy networks (RPL) is a standardized and default routing protocol for low power lossy networks. However, this is basically designed for sensor networks with scalar data and not optimised for the networks with multi-modal sensors. The data rate of each multi-modal sensor varies based on various applications. RPL suffers from packet drops and re-transmissions which results in packet loss and energy consumption in case of multi-modal data transmission. Hence, the routing strategy implemented in RPL needs better scheduling strategy at parent node for forwarding packets based on various parameters. In this paper, relevant Objective Functions for multi-modal sensor data communication is proposed based on various parameters identified and a weighted ranking based scheduling strategy is proposed for multi-modal data communication called R-RPL. The goal of proposed ranking based RPL (R-RPL) is to increase the throughput and reduce the loss in terms of energy and delay based on proposed scheduling strategy for parent selection. The performance of the proposed R-RPL is evaluated in the contiki based Cooja simulator and compared with RPL protocol. The analysis shows that the R-RPL performs better compared to RPL with respect to packet delivery ratio and energy consumption.
Clinical validation, implementation, and reporting of polygenic risk scores for common diseases
Authors: Vassy Jason , Hao Limin , Kraft Peter , Berriz Gabriel , Hynes Elizabeth , Koch Christopher , Kumar Prathik , Parpattedar Shruti , Steeves Marcie , Yu Wanfeng , Antwi Ashley , Brunette Charles , Danowski Morgan , Gala Manish , Green Robert , Jones Natalie , Lewis Anna , Lubitz Steven , Natajaran Pradeep , Lebo Matthew 
Published: August 2021

Abstract
Implementation of polygenic risk scores (PRS) may improve disease prevention and management but requires the construction and validation of clinical assays, interpretation, and reporting pipelines. We developed a clinical genotype array-based assay for published PRS for 6 common diseases. First, we calculated PRS for 36,423 Mass General Brigham Biobank (MGBB) participants. Finding significant variation in the PRS distributions by race, we implemented adjustment for population structure with ancestry-informative principal components. We replicated published thresholds for odds ratio (OR)>2 in MGBB overall [ranging from 1.75 (1.57, 1.95) for Type 2 diabetes to 2.38 (2.07, 2.73) for breast cancer]. After confirming the high performance and robustness of the pipeline for use as a clinical assay, we analyzed the first 141 prospective samples from the Genomic Medicine at VA Study; frequency of PRS corresponding to published OR>2 ranged from 5/141 (3.6%) for colorectal cancer to 8/48 (16.7%) for breast cancer. Our development of a clinical PRS assay for multiple conditions illustrates the generalizability of this process and necessary technical and reporting decisions for meaningful clinical PRS implementation.
In situ grown bifacial graphene stabilizes composite electrode for efficient perovskite solar cells
Authors: Han Liyuan , Lin Xuesong , Su Hongzhen , He Sifan , Song Yenan , Wang Yanbo , Qin Zhenzhen , Wu Yongzhen , Yang Xudong , Han Qifeng , Fang Junfeng , Graetzel Michael 
Published: August 2021

Abstract
Instability of rear electrodes undermines the long-term operational durability of efficient perovskite solar cells (PSCs). Here, a composite electrode of copper-nickel (Cu-Ni) alloy stabilized by in situ grown bifacial graphene is designed. The alloying makes the work function of Cu suitable for regular PSCs and Cu-Ni is the ideal substrate for preparing high-quality graphene via chemical vapor deposition, which simultaneously protects the device from oxygen, water and internal components reaction. To rivet the composite electrode with semi-device, a thermoplastic copolymer is employed as an adhesive layer during hot pressing. The resultant device achieved power conversion efficiency of 24.34% with significantly improved stability; the devices without encapsulation retained 97% of their initial efficiency after the damp heat test at 85oC with relative humidity of 85% for 1440 hours and the encapsulated devices maintained 95% of their initial efficiencies after maximum power point tracking under continuous 1 sun illumination for 5000 hours.
Rheumatoid Arthritis, as a Clinical Disease, but Not Rheumatoid Arthritis-associated Autoimmunity is Linked to Cardiovascular Events
Authors: Gouze Helene , Aegerter Philippe , Said-Nahal Roula , Zins Marie , Goldberg Marcel , Morelle Guillaume , Schett Georg , Breban Maxime , D’Agostino Maria-Antonietta 
Published: August 2021

Abstract
Background: Rheumatoid Arthritis (RA) is characterized by increased cardiovascular (CV) mortality. CV events are particularly high in patients with RA-specific autoimmunity, including rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), raising the question whether RA-specific autoimmunity itself is associated with CV events.Methods: New CV events (myocardial infarction, stroke or death by CV cause) were recorded in 20,625 subjects of the Electricité de France – Gaz de France (GAZEL) cohort. Self-reported RA cases in the GAZEL cohort were validated by phone interview on the basis of a specific questionnaire. In 1,618 subjects, in whom serum was available, RF and ACPA were measured. A piecewise exponential Poisson regression was used to analyze the association of CV events with presence of RA as well as RA-specific autoimmunity (without RA).Results: CV events in GAZEL were associated with age, male sex, smoking, hypertension, hyperlipidemia and diabetes mellitus (HR from 1.06 to 1.87, p < 0.05). Forty-two confirmed RA cases were identified. Confirmed RA was significantly associated with CV risk increase (HR of 3.03; 95% CI: 1.13-8.11, p=0.03) independently of conventional CV risk factors. One hundred seventy-eight subjects showed RF or ACPA positivity without presence of RA. CV events were not associated with ACPA positivity (HR: 1.52, 95% CI: 0.47-4.84, p= 0.48) or RF positivity (HR: 1.15, 95% CI: 0.55-2.40, p= 0.70) in the absence of RA.Conclusions: RA, as a clinical chronic inflammatory disease, but not mere positivity for RF or ACPA in the absence of clinical disease is associated with increased CV risk.
Factors Affecting Drug Retention of Janus kinase Inhibitors in Patients with Rheumatoid Arthritis: The ANSWER Cohort Study
Authors: Ebina Kosuke , Hirano Toru , Maeda Yuichi , Yamamoto Wataru , Hashimoto Motomu , Murata Koichi , Onishi Akira , Jinno Sadao , Hara Ryota , Son Yonsu , Amuro Hideki , Takeuchi Tohru , Yoshikawa Ayaka , Katayama Masaki , Yamamoto Keiichi , Okita Yasutaka , Hirao Makoto , Etani Yuki , Kumanogoh Atsushi , Okada Seiji , Nakata Ken 
Published: August 2021

Abstract
Background: This multi-center, retrospective study aimed to clarify the factors affecting drug retention of the Janus kinase inhibitors (JAKi) baricitinib (BAR) and tofacitinib (TOF) in patients with RA.Methods: Patients were included as follows: females, 80.6%; age, 60.5 years; DAS28-ESR, 4.3; treated with either BAR (n = 166) or TOF (n = 185) and concomitant glucocorticoid (prednisolone [PSL] equivalent) 5.3 mg/day (46.7%) or methotrexate (MTX) 8.9 mg/week (60.7%); bDMARDs- or JAKi-switched cases (76.6%). The reasons for drug discontinuation were classified into four major categories: lack of effectiveness, toxic adverse events, non-toxic reasons and remission. The drug retention rate was estimated at 24 months using the Kaplan–Meier method and adjusted for potential confounders using multivariate Cox proportional hazards modelling.Results: Adjusted discontinuation rates for the corresponding reasons were as follows: lack of effectiveness (22.3%), toxic adverse events (13.3%), non-toxic reasons (7.2%) and remission (0.0%). Prior use of anti-interleukin-6 receptor antibody (aIL-6R) was significantly associated with discontinuation due to lack of effectiveness (P = 0.021). Ageing (P = 0.015), usage of PSL ≥5 mg/day (P = 0.017) and female sex (P = 0.041) were significantly associated with discontinuation due to toxic adverse events. Factors not associated with treatment discontinuation were: number of prior bDMARDs or JAKi, concomitant MTX usage, different JAKi and prior use of TNF inhibitor, CTLA4-Ig or other JAKi.Conclusions: Prior use of aIL-6R was associated with discontinuation due to lack of effectiveness, while ageing (≥75 years), PSL usage ≥5 mg/day, and female sex were associated with discontinuation due to toxic adverse events.