bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasticity of root anatomy during domestication of a maize-teosinte derived population
Authors: Chen Zhe , Sun Junli , Li Dongdong , Li Pengcheng , He Kunhui , Ali Farhan , Mi Guohua , Chen Fanjun , Yuan Lixing , Pan Qingchun 
Published: September 2021

AbstractMaize (Zea mays L.) has undergone profound changes in root anatomy for environmental adaptation during domestication. However, the genetic mechanism of plasticity of maize root anatomy during the domestication process remains unclear. In this study, high-resolution mapping was performed for nine root anatomical traits using a maize-teosinte population (mexicana × Mo17) across three environments. Large genetic variations were detected for different root anatomical traits. The cortex, stele, aerenchyma areas, xylem vessel number, and cortical cell number had large variations across three environments, indicating high plasticity. Sixteen quantitative trait loci (QTL) were identified, including seven QTL with QTL × environment interaction (EIQTL) for high plasticity traits and nine QTL without QTL × environment interaction (SQTL). Most of the root loci were consistent with shoot QTL depicting domestication signals. Combining transcriptome and genome-wide association studies revealed that AUXIN EFFLUX CARRIER PIN–FORMED LIKE 4 (ZmPILS4) serves as a candidate gene underlying a major QTL of xylem traits. The near-isogenic lines (NILs) with lower expression of ZmPILS4 had 18–24% more auxin concentration in the root tips and 8–15% more xylem vessels. Nucleotide diversity values analysis in the promoter region suggested that ZmPILS4 was involved in maize domestication and adaptation. These results revealed the potential genetic basis of root anatomical plasticity during domestication.
BnaC7.ROT3, the causal gene of cqSL-C7, mediates silique length by affecting cell elongation in Brassica napus
Authors: Zhou Xianming , Zhang Haiyan , Wang Pengfei , Liu Ying , Zhang Xiaohui , Song Yixian , Wang Zhaoyang , Ali Ahmad , Wan Lili , Yang Guangsheng , Hong Dengfeng 
Published: September 2021

Abstract
Siliques are a major carbohydrate source of energy for later seed development in rapeseed (Brassica napus). Thus, silique length has received great attention from breeders. We previously detected a novel quantitative trait locus cqSL-C7 that controls silique length in B. napus. Here, we further validated the cqSL-C7 locus and isolated its causal gene (BnaC7.ROT3) by map-based cloning. In ‘Zhongshuang11’ (parent line with long siliques), BnaC7.ROT3 encodes the potential cytochrome P450 monooxygenase CYP90C1, whereas in ‘G120’ (parent line with short siliques), a single nucleotide deletion in the fifth exon of BnaC7.ROT3 results in a loss-of-function truncated protein. Sub-cellular localization and expression pattern analysis revealed that BnaC7.ROT3 is a membrane-localized protein mainly expressed in leaves, flowers and siliques. Cytological observations showed that the cells in silique walls of BnaC7.ROT3-transformed positive plants were longer than those of transgene-negative plants in the background of ‘G120’, suggesting that BnaC7.ROT3 affects cell elongation. Haplotype analysis demonstrated that most alleles of BnaC7.ROT3 are favorable in B. napus germplasms, and its homologs may also be involved in silique length regulation. Our findings provide novel insights into the regulatory mechanisms of natural silique length variations and valuable genetic resources for the improvement of silique length in rapeseed.
MdUGT88F1-mediated phloridzin biosynthesis coordinates carbon and nitrogen accumulation in apple
Authors: Zhou Kun , Hu Lingyu , Yue Hong , Zhang Zhijun , Zhang Jingyun , Gong Xiaoqing , Ma Fengwang 
Published: September 2021

AbstractThe high accumulation of phloridzin makes apple (Malus domestica) unique in the plant kingdom, which suggests a vital role of its biosynthesis in physiological processes. In our previous study, silencing MdUGT88F1 (a key UDP-GLUCOSE: PHLORETIN 2’-O-GLUCOSYLTRANSFERASE gene) revealed the importance of phloridzin biosynthesis in apple development and Valsa canker resistance. Here, results from MdUGT88F1-silenced lines showed that phloridzin biosynthesis was indispensable for normal chloroplast development and photosynthetic carbon fixation by maintaining MdGLK1/2 (GOLDEN2-like1/2) expression. Interestingly, increased phloridzin biosynthesis did not affect plant (or chloroplast) development, but reduced nitrogen accumulation, leading to chlorophyll deficiency, light sensitivity, and sugar accumulation in MdUGT88F1-overexpressing apple lines. Further analysis revealed that MdUGT88F1-mediated phloridzin biosynthesis negatively regulated the cytosolic glutamine synthetase1-asparagine synthetase-asparaginase (GS1-AS-ASPG) pathway of ammonium assimilation and limited chlorophyll synthesis in apple shoots. The interference of phloridzin biosynthesis in the GS1-AS-ASPG pathway was also assumed to be associated with its limitation of the carbon skeleton of ammonium assimilation through metabolic competition with the tricarboxylic acid cycle. Taken together, our findings shed light on the role of MdUGT88F1-mediated phloridzin biosynthesis in the coordination between carbon and nitrogen accumulation in apple trees.
Overuse Injury in Military Working Dog Handlers: A Pattern of Behavior and a Path to Prevention
Authors: Patt Michael W , Oh Jeremiah T , Branstetter Joanna G , Benavides Jerome M 
Published: September 2021

ABSTRACT
Military working dog handlers and their canine partners continue to be invaluable team members on missions of national importance, but little information exists in the medical literature regarding specific musculoskeletal injuries to military working dog handlers. We report a case of a dog handler with overuse shoulder traction injuries due to leash lunges from their dog in an effort to provide diagnostic insight and treatment options and look at prevention of common musculoskeletal manifestations of overuse in working dog handlers.
Understanding matched filters for precision cosmology
Authors: Zubeldia Íñigo , Rotti Aditya , Chluba Jens , Battye Richard 
Published: September 2021

Abstract
Matched filters are routinely used in cosmology in order to detect galaxy clusters from mm observations through their thermal Sunyaev–Zeldovich (tSZ) signature. In addition, they naturally provide an observable, the detection signal-to-noise or significance, which can be used as a mass proxy in number counts analyses of tSZ-selected cluster samples. In this work, we show that this observable is, in general, non-Gaussian, and that it suffers from a positive bias, which we refer to as optimization bias. Both aspects arise from the fact that the signal-to-noise is constructed through an optimization operation on noisy data, and hold even if the cluster signal is modelled perfectly well, no foregrounds are present, and the noise is Gaussian. After reviewing the general mathematical formalism underlying matched filters, we study the statistics of the signal-to-noise with a set Monte Carlo mock observations, finding it to be well-described by a unit-variance Gaussian for signal-to-noise values of 6 and above, and quantify the magnitude of the optimization bias, for which we give an approximate expression that may be used in practice. We also consider the impact of the bias on the cluster number counts of Planck and the Simons Observatory (SO), finding it to be negligible for the former and potentially significant for the latter.
Atomic data and the density structures of planetary nebulae
Authors: Juan de Dios Leticia , Rodríguez Mónica 
Published: September 2021

ABSTRACT
We study the density structures of planetary nebulae implied by four diagnostics that sample different regions within the nebulae: [S ii] λ6716/λ6731, [O ii] λ3726/λ3729, [Cl iii] λ5518/λ5538, and [Ar iv] λ4711/λ4740. We use a sample of 46 objects with deep spectra that allow the calculation of the electron density from these four diagnostics, and explore the impact that different atomic data have on the results. We compare the observational results with those obtained from photoionization models characterized by three different density structures. We conclude that the atomic data used in the calculations of electron density fully determine the density structures that are derived for the objects. We illustrate this by selecting three combinations of atomic data that lead to observational results that are compatible with each of the three different density structures explored with the models.
Determining the full satellite population of a Milky Way-mass halo in a highly resolved cosmological hydrodynamic simulation
Authors: Grand Robert J J , Marinacci Federico , Pakmor Rüdiger , Simpson Christine M , Kelly Ashley J , Gómez Facundo A , Jenkins Adrian , Springel Volker , Frenk Carlos S , White Simon D M 
Published: September 2021

ABSTRACT
We investigate the formation of the satellite galaxy population of a Milky Way-mass halo in a very highly resolved magnetohydrodynamic cosmological zoom-in simulation (baryonic mass resolution mb = 800 $\rm M_{\odot }$). We show that the properties of the central star-forming galaxy, such as the radial stellar surface density profile and star formation history, are (i) robust to stochastic variations associated with the so-called Butterfly Effect and (ii) well converged over 3.5 orders of magnitude in mass resolution. We find that there are approximately five times as many satellite galaxies at this high resolution compared to a standard ($m_b\sim 10^{4-5}\, \rm M_{\odot }$) resolution simulation of the same system. This is primarily because two-thirds of the high-resolution satellites do not form at standard resolution. A smaller fraction (one-sixth) of the satellites present at high-resolution form and disrupt at standard resolution; these objects are preferentially low-mass satellites on intermediate- to low-eccentricity orbits with impact parameters ≲30 kpc. As a result, the radial distribution of satellites becomes substantially more centrally concentrated at higher resolution, in better agreement with recent observations of satellites around Milky Way-mass haloes. Finally, we show that our galaxy formation model successfully forms ultra-faint galaxies and reproduces the stellar velocity dispersion, half-light radii, and V-band luminosities of observed Milky Way and Local Group dwarf galaxies across six orders of magnitude in luminosity (103–$10^{9}\, \rm L_{\odot }$).
Statistical tests of young radio pulsars with/without supernova remnants: implying two origins of neutron stars
Authors: Cui Xiang-Han , Zhang Cheng-Min , Li Di , Zhang Jian-Wei , Peng Bo , Zhu Wei-Wei , Wu Qing-Dong , Wang Shuang-Qiang , Wang Na , Wang De-Hua , Yang Yi-Yan , Diao Zhen-Qi , Ye Chang-Qing , Chang Hsiang-Kuang 
Published: September 2021

ABSTRACT
The properties of the young pulsars and their relations to the supernova remnants (SNRs) have been the interesting topics. At present, 383 SNRs in the Milky Way Galaxy have been published, which are associated with 64 radio pulsars and 46 pulsars with high-energy emissions. However, we noticed that 630 young radio pulsars with the spin periods of less than half a second have been not yet observed the SNRs surrounding or nearby them, which arises a question of that could the two types of young radio pulsars with/without SNRs hold the distinctive characteristics? Here, we employ the statistical tests on the two groups of young radio pulsars with (52) and without (630) SNRs to reveal if they share the different origins. Kolmogorov–Smirnov (K–S) and Mann–Whitney–Wilcoxon (M–W–W) tests indicate that the two samples have the different distributions with parameters of spin period (P), derivative of spin period ($\dot{P}$), surface magnetic field strength (B), and energy loss rate ($\dot{E}$). Meanwhile, the cumulative number ratio between the pulsars with and without SNRs at the different spin-down ages decreases significantly after $\rm 10\!-\!20\, kyr$. So we propose that the existence of the two types of supernovae (SNe), corresponding to their SNR lifetimes, which can be roughly ascribed to the low- and high-energy SNe. Furthermore, the low-energy SNe may be formed from the $\rm 8\!-\!12\, M_{\odot }$ progenitor, e.g. possibly experiencing the electron capture, while the main-sequence stars of $\rm 12\!-\!25\, M_{\odot }$ may produce the high-energy SNe probably by the iron core collapse.
Asteroseismology of low-mass stars: the balance between partial ionization and Coulomb interactions
Authors: Brito Ana , Lopes Ilídio 
Published: September 2021

ABSTRACT
All cool stars with outer convective zones have the potential to exhibit stochastically excited stellar oscillations. In this work, we explore the outer layers of stars less massive than the Sun. In particular, we have computed a set of stellar models ranging from 0.4 to 0.9 M⊙ with the aim at determining the impact on stellar oscillations of two physical processes occurring in the envelopes of these stars. Namely, the partial ionization of chemical elements and the electrostatic interactions between particles in the outer layers. We find that alongside with partial ionization, Coulomb effects also impact the acoustic oscillation spectrum. We confirm the well-known result that as the mass of a star decreases, the electrostatic interactions between particles become relevant. We found that their impact on stellar oscillations increases with decreasing mass, and for the stars with the lowest masses (M ≲ 0.6 M⊙), it is shown that Coulomb effects dominate over partial ionization processes producing a strong scatter on the acoustic modes. The influence of Coulomb interactions on the sound-speed gradient profile produces a strong oscillatory behaviour with diagnostic potential for the future.
Lyman-alpha opacities at z = 4–6 require low mass, radiatively-suppressed galaxies to drive cosmic reionization
Authors: Ocvirk Pierre , Lewis Joseph S W , Gillet Nicolas , Chardin Jonathan , Aubert Dominique , Deparis Nicolas , Thélie Émilie 
Published: September 2021

ABSTRACT
The high redshift Lyman-α forest, in particular the Gunn-Peterson trough, is the most unambiguous signature of the neutral to ionized transition of the intergalactic medium (IGM) taking place during the Epoch of Reionization. Recent studies have shown that reproducing the observed Lyman-α opacity distributions after overlap required a non-monotonous evolution of cosmic emissivity: rising, peaking at z ∼ 6, and then decreasing onwards to z = 4. Such an evolution is puzzling considering galaxy buildup and the cosmic star formation rate are still continously on the rise at these epochs. Here, we use new RAMSES-CUDATON simulations to show that such a peaked evolution may occur naturally in a fully coupled radiation-hydrodynamical framework. In our fiducial run, cosmic emissivity at z &gt; 6 is dominated by a low mass (${\rm M_{DM}}\lt 2 \times 10^9 \rm \,M_{\odot }$), high escape fraction halo population, driving reionization, up to overlap. Approaching z = 6, this population is radiatively suppressed due to the rising ionizing UV background, and its emissivity drops. In the meantime, the high mass halo population builds up and its emissivity rises, but not fast enough to compensate the dimming of the low mass haloes, because of low escape fractions. The combined ionizing emissivity of these two populations therefore naturally results in a rise and fall of the cosmic emissivity, from z = 12 to z = 4, with a peak at z ∼ 6. An alternative run, which features higher escape fractions for the high mass haloes and later suppression at low mass, leads to overshooting the ionizing rate, over-ionizing the IGM and therefore too low Lyman-α opacities.
Galaxy evolution on resolved scales: ageing and quenching in CALIFA
Authors: Corcho-Caballero P , Casado J , Ascasibar Y , García-Benito R 
Published: September 2021

ABSTRACT
This work investigates the fundamental mechanism(s) that drive galaxy evolution in the local Universe. By comparing two proxies of star formation sensitive to different time-scales, such as EW($\rm H\,\alpha$) and colours like g − r, one may distinguish between smooth secular evolution (ageing) and sudden changes (quenching) in the recent star formation history of galaxies. Building upon the results obtained from a former study based on 80 000 Sloan Digital Sky Survey (SDSS) single-fibre measurements, we now focus on spatially resolved (on kpc scales) galaxies, comparing with a sample of 637 nearby objects observed by the Calar Alto Legacy Integral-Field Area survey. In general, galaxies cannot be characterized in terms of a single ‘evolutionary stage’. Individual regions within galaxies arrange along a relatively narrow ageing sequence, with some intrinsic scatter possibly due to their different evolutionary paths. These sequences, though, differ from one galaxy to another, although they are broadly consistent with the overall distribution found for the (central) SDSS spectra. We find evidence of recent quenching episodes (relatively blue colours and strong $\rm H\,\alpha$ absorption) in a small fraction of galaxies (most notably, low-mass ellipticals), on global scales and individual regions (particularly at high metallicity). However, we argue that most of the systems, over their entire extent, are compatible with a secular inside-out scenario, where the evolutionary stage correlates with both global (mass, morphology, and environment) and local (surface brightness and metallicity) properties.
Relationship between genetically determined telomere length and glioma risk
Authors: Saunders Charlie N , Kinnersley Ben , Culliford Richard , Cornish Alex J , Law Philip J , Houlston Richard S 
Published: September 2021

Abstract

Background
Telomere maintenance is increasingly recognized as being fundamental to glioma oncogenesis with longer leukocyte telomere length (LTL) reported to increase risk of glioma. To gain further insight into the relationship between telomere genetics and risk of glioma, we conducted several complementary analyses, using genome-wide association studies data on LTL (78 592 individuals) and glioma (12 488 cases and 18 169 controls).

Methods
We performed both classical and summary Mendelian randomization (SMR), coupled with heterogeneity in dependent instruments tests, at genome-wide significant LTL loci to examine if an association was mediated by the same causal variant in glioma. To prioritize genes underscoring glioma-LTL associations, we analyzed gene expression and DNA methylation data.

Results
Genetically increased LTL was significantly associated with increased glioma risk, random-effects inverse variance weighted ORs per 1 SD unit increase in the putative risk factor (odds ratio [OR]SD) 4.79 (95% confidence interval: 2.11-10.85; P = 1.76 × 10−4). SMR confirmed the previously reported LTL associations at 3q26.2 (TERC; PSMR = 1.33 × 10−5), 5p15.33 (TERT; PSMR = 9.80 × 10−27), 10q24.33 (STN1 alias OBFC1; PSMR = 4.31 × 10−5), and 20q13.3 (STMN3/RTEL1; PSMR = 2.47 × 10−4) glioma risk loci. Our analysis implicates variation at 1q42.12 (PSMR = 1.55 × 10−2), 6p21.3 (PSMR = 9.76 × 10−3), 6p22.2 (PSMR = 5.45 × 10−3), 7q31.33 (PSMR = 6.52 × 10−3), and 11q22.3 (PSMR = 8.89 × 10−4) as risk factors for glioma risk. While complicated by patterns of linkage disequilibrium, genetic variation involving PARP1, PRRC2A, CARMIL1, POT1, and ATM-NPAT1 was implicated in the etiology of glioma.

Conclusions
These observations extend the role of telomere-related genes in the development of glioma.
Intraoperative Methadone Use in Cardiac Surgery: A Systematic Review
Authors: Lobova Veronika A , Roll John M , Roll Marshall L C 
Published: September 2021

Abstract

Objective
To investigate the effects of intraoperative methadone in comparison with those of standard-of-care intraoperative opioids, such as fentanyl and morphine, on pain scores, opioid consumption, and adverse effects in adults undergoing cardiothoracic surgery.

Methods
The literature was reviewed in PubMed, Embase, Cochrane Library, and Google Scholar, followed by a manual search of the reference lists of the identified articles. Search terms included a combination of “intraoperative methadone,” “methadone,” and “cardiac surgery.” Our review includes four studies published between 2011 and 2020. Quality assessment of the studies was performed.

Results
The initial search identified 715 articles, from which 461 duplicates were removed and 236 were eliminated on the basis of inclusion and exclusion criteria. Eighteen articles underwent full-text review. Four studies evaluating a total of 435 patients with various cardiothoracic procedures were included in this review. We found that intraoperative methadone decreased acute postoperative pain and reduced postoperative opioid consumption in the first 24 postoperative hours in patients who received 0.1–0.3 mg/kg intraoperative methadone in comparison with morphine and fentanyl. No difference was found in adverse effects between the groups. Quality assessment of the studies showed a low risk of bias in three of the randomized controlled trials and a high risk of bias in the retrospective review because of the baseline confounding bias in the study design.

Conclusions
Intraoperative methadone use reduces acute postoperative pain and lowers opioid consumption in comparison with morphine and fentanyl. Initial results suggest that methadone may be an equivalent opioid to be administered during cardiothoracic procedures to reduce acute postsurgical pain, though further research is warranted.
Multivalve infective endocarditis in intravenous drug using patients: an epidemiological study
Authors: Khan Isa , Brookes Elizabeth , Yaftian Nima , Wilson Andrew , Darby Jonathan , Newcomb Andrew 
Published: September 2021

Summary

Background
Infective endocarditis (IE) remains a life-threatening condition. Intravenous drug use (IVDU) adds to the clinical challenge associated with IE due to clinical aberrations caused by the social issues associated with this population.

Aim
To improve survival, this study aimed to characterize the contemporary IVDU-associated IE population seen at our tertiary hospital, determine their long-term outcomes and find risk factors associated with mortality.

Design
Retrospective observational cohort study.

Methods
A total of 79 patients accounting for 89 presentations were treated for IVDU-associated IE at St Vincent’s Hospital Melbourne (SVHM) between 1999 and 2015. Patients were followed-up until death or January 2021. The primary outcome was all-cause mortality and Kaplan–Meier survival analysis was used to calculate long-term survival estimates. Cox proportional hazards analysis was used to examine risk factors for mortality.

Results
The IVDU population treated at SVHM had a high rate of multivalvular IE, at 18.98%. Multivariate analysis revealed that multivalvular IE is significantly associated with an increased risk of mortality in a dose–dependent relationship (two valves affected: HR = 4.73, P = 0.006, three valves affected: HR = 14.19, P = 0.014). The IVDU population has survival estimates of 83.78% (95%CI: 73.21–90.45%) at 1-year and 64.98% (95%CI: 50.94–75.92%) at 15-years.

Conclusion
IVDU patients have high rates of multivalvular endocarditis, which is associated with increased risk of mortality and difficult to identify on echocardiography. Clinicians should be suspicious of multivalve involvement in the IVDU population and decisions related to medical management/intervention should be made with the understanding that these patients are at a higher risk of death.