bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic outcomes of left gastric artery embolization in obese patients (a pilot study)
Authors: Ramazanova Z. D. , Ametov A. S. , Pashkova E. Yu. , Khovalkin R. G. , Shpitonkov M. I. 
Published: October 2021

Rationale: According to the published data, bariatric procedure of left gastric artery embolization (LGAE) as one of the minimally invasive and innovative methods for obesity treatment promotes reductions in bodyweight and ghrelin levels.Aim: To evaluate the effect of LGAE on the parameters of fat and carbohydrate metabolism in obese patients.Materials and methods: Twenty three (23) patients (10 male and 13 female, mean age 40.2 ± 10.6 years) with morbid obesity (body mass index [BMI] > 40 kg/m2) and obesity grade 2 (BMI > 35 kg/m2) underwent a minimally invasive procedure in the form of bariatric embolization of the left gastric artery with polyvinyl alcohol particles of 500 to 700 mcm in diameter. We compared anthropometric parameters (height in cm, body-weight in kg, BMI in kg/m2, waist circumference in cm) at baseline and at 6 months after LGAE. Laboratory examinations included measurements of plasma adiponectin, ghrelin, leptin, fasting glucose, HbA1c, insulin, and HOMA-IR (insulin resistance index).Results: At 6 month after LGAE, the patients' bodyweight decreased from 138.1 ± 33.2 kg to 113 ± 26 kg (p < 0.01) (by 18.2%), BMI from 47.4 ± 9.3 kg/m2 to 38.1 ± 7.4 kg/m2 (p < 0.01) (by 19.6%), waist circumference from 130.4 ± 9.7 cm to 115 ± 10.3 cm (p < 0.01) (by 11.8%). Mean adiponectin levels increased significantly from 22.5 ± 8.1 μg/ml before LGAE to 42.4 ± 11 μg/ml at 6 months (p < 0.001) (by 88.4%). Baseline ghrelin levels of 20.23 ± 4.8 femtomol/μL decreased to 2.09 ± 0.6 femtomol/μL at 6 months (p < 0.001) (by 89.6%). Mean leptin levels were 23.3 ± 4.9 ng/ml and 10.5 ± 3.7 ng/ml at baseline and at 6 months, respectively (p < 0.001) (by 54.9%). At 6 months after LGAE, there was a positive and significant trends in the parameters of carbohydrate metabolism: fasting glucose decreased from 6.9 ± 1.5 mmol/L to 5.1 ± 0.9 mmol/L (p < 0.001) (by 26%), HbA1c from 6.2 ± 1% to 5.3 ± 0.6% (p < 0.01) (by 14.5%), insulin from 15.6 ± 7.7 μU/ml to 8.1 ± 0.7 μU/ml (p < 0.001) (by 48%), and the HOMA-IR index from 4.5 ± 1.2 to 1.9 ± 0.32 (p < 0.001) (by 57.7%).Conclusion: At 6 months after LGAE, the patients with obesity grades 2 and 3 have demonstrated a reduction in bodyweight of 18–19%, with a decrease in the levels of leptin (the obesity hormone), ghrelin (hunger inducing hormone), and an increase in adiponectin levels, which is a marker of metabolic health. The patients also achieved their individual glycemic goals with a decrease in fasting glucose, insulin, glycated hemoglobin, and demonstrated an improvement in HOMA-IR.
Codification Problems of Legislation on Sanitary and Epidemiological Welfare of the Population of the Russian Federation
Authors: Sakhno A. I. 
Published: October 2021

The current problems of administrative-legal regulation in the field of health protection and ensuring the sanitary-epidemiological well-being of the population of the Russian Federation are investigated, eurrent trends in its development and problems of systematization are considered. Based on the analysis of statistieal data and the practice of applying international legal acts regulating the issues of interaction in the field of preventing the spread of dangerous infectious diseases, the conclusions and recommendations of the World Health Organization and other international organizations, proposals are formulated for further improvement of national legislation in the field of ensuring the sanitary and epidemiological well-being of the population, methods are proposed its systematization and options for possible codification. The features of the mechanism of administrative and legal regulation of relations that develop during the implementation of state sanitary and epidemiological supervision in the conditions of the spread of dangerous diseases are analyzed. A new model for the development of sectoral legislation in the field of sanitary and epidemiological welfare is proposed, based on modern criteria and principles of systematization of regulatory legal acts that ensure sanitary and epidemiological welfare of the population and protection of public health. The main versions of draft model laws in the form of codified legal acts aimed at improving the activities of executive authorities and their officials performing the functions of state regulation and sanitary and epidemiological supervision in the studied sphere of relations are submitted for discussion.
Nullity of Administrative Acts: Grounds, Legal Regime, Discretion
Authors: Sherstoboev O. N. 
Published: October 2021

The issues of criteria for the nullity of administrative acts are considered, the ratio of an illegal and invalid act, as well as a null and void act, analyzed, the possibility of administrative discretion in determining an invalid administrative act is analyzed, the role of vague legal concepts when an administrative act is declared invalid is demonstrated. The Author uses a comparative legal method, including the analysis of the practice of Germany, Great Britain, South Africa, Canada, Japan, South Korea, Russia and other countries. Special attention is paid to the laws on administrative procedures adopted in the post-Soviet territory and the influence of the German doctrine on this process. It is concluded that for the continental legal order the most preferable way to formalize the criteria for the invalidity of an administrative act are laws on administrative procedures or their analogs, while in the common law states, legal doctrine and judicial practice are of great importance. At the same time, many countries avoid recognizing acts as null and void, preferring the construction of their voidability. This is related to ensuring the stability of public administration, the predictability of administrative activities, and the protection of legitimate expectations. In any case, the theory of the reality of the administrative act is prevailing, and nullity is rather viewed as an anomaly. Therefore, only acts that are adopted with the most significant violations, which do not allow talking about the fair consequences of their adoption, are considered invalid. The illegality of an act does not automatically entail its nullity. A similar trend can be traced in Russia, although individual norms of law and practice of courts indicate the possible formation of a doctrine of the invalidity of an administrative act in the Russian legal system. Insignificant acts do not give rise to consequences from the moment of their adoption, legally they do not exist, and nothing can generate anything. With this approach, the courts only fix the criterion of invalidity without a dispute about law. Insignificant acts should be distinguished from contested ones, the latter may turn out to be illegal, but for a number of reasons (for example, protection of trust) the fact of their existence is confirmed along with their consequences.
Além da forma-movimento: compilações do Movimento dos Pequenos Agricultores
Authors: Carvalho Priscila Delgado de 
Published: October 2021

Criado em meados da década de 1990, o Movimento dos Pequenos Agricultores foi inicialmente conhecido por suas demandas por crédito e por habitação rural. Ao longo dos anos, o MPA propôs também debates sobre o campesinato no Brasil, formulou ou ressignificou conceitos como alimergia e sistemas camponeses de produção, engajou-se em debates sobre políticas públicas, criou cooperativas e estruturou um Plano Camponês que orienta sua ação. O artigo reúne elementos da trajetória do MPA argumentando que a forma-movimento é sua primeira face visível, mas o MPA também construiu outros modos de compilar. Entre elas, a produção de conceitos em estreito diálogo com a academia e com debates de origem transnacional e a estruturação de projetos produtivos.
A Real World Study: What is The Proper Dose of PEG-rhG-CSF for Grade IV Myelosuppression in Asian Cancer Patients?
Authors: Fu Changfang , Li Yan , Han Xinhua 
Published: October 2021

Abstract
Purpose To evaluate the efficacy, safety and cost-effectiveness of different doses of PEGylated recombinant human granulocyte stimulating factor (PEG-rhG-SF) for grade IV myelosuppression in Asian cancer patients.Methods One hundred and thirty-two cases of patients with malignant tumors who had grade IV myelosuppression after chemotherapy from January 2019 to December 2020 were collected. According to the different doses, they were divided into two groups: 76 cases in group A (3mg PEG-rhG-CSF) and 56 cases in group B (6mg PEG-rhG-CSF). Clinical efficacy and adverse reactions were compared, and treatment cost was calculated so that cost-effectiveness analysis in pharmacoeconomic was compared between two groups.Results There was no significant difference in clinical efficacy between group A and group B (p > 0.05). There were no death, febrile neutropenia (FN) and hospitalization during the chemotherapy cycles. The incidences of adverse reactions were 15.79% and 32.14% in group A and group B and showed a significant difference (p < 0.05). The cost of these two regimens was RMB 1713 for group A and RMB 3418 for group B, the regimen in group A was more economical.Conclusion The regimen in group A (3mg PEG-rhG-CSF) is the proper option for grade IV myelosuppression in Asian cancer patients, considering the efficacy, safety, and cost-effectiveness analysis.
Circularly Polarized (CP) Wideband on Fabric (Textile) Stealth MIMO Antenna for Wearable Wireless UWB Applications
Authors: Laxman Pillalamarri , JAIN ANUJ 
Published: October 2021

Abstract
Stealth wearable wireless devices gained popularity in the personal security and fashion design industry. A multiple-input-output (MIMO) wideband circularly polarized textile is described in the present paper, where a wearable application uses a multiple-input-output (M.I.M.O). It consists of two MIMO antennas, the resonating elements are shaped like a peacock, and the ground plane is similar to a beautiful peacock. A voltage is applied to each antenna element; the ground plane contains a a Peacock-shaped small strip antenna used for circular polarizing. The antenna covers 3dB Axial Ratio Band-Width (A.R.B.W.) of 5.0–7.0 GHz and impedance bandwidth (S11 ≤ −10.5 dB) of 3.7–13.5 GHz. The improved fabric-textile Multple-input-multiple-output antenna showing Channel-Capacity-Loss about (C.C.L) <0.20 bits/sec/Hz, & Envelope-Correlation-Coefficient (E.C.C) less than 0.021, Total Active-Reflective-Coefficient (T.A.R.C) close to -10.4 dB , DiversityGain (D.G) close to 9.96, Mean-Effective-Gain (M.E.G) ratio close to ±0.5 dB . A Specific-Absorption-Rate(S.A.R) of the proposed antenna for tissues of human specimens is also discussed for different situations pertaining to the human body. The final dimention of the presented Circularly-Polarized textile wearable Multple-input-multiple-output antenna is 34:5×41×1.1mm3. The proposed antenna can make unrecognizable because of the beautiful peacock design that can easily mix with the designs of fabric.
Development and Validation of a Simple-to-Use Nomogram to Predict 3-Year Recurrence rate of Ovarian Cancer
Authors: Lin Yaduan , Zhu Shuo , He Fanchen , Wei Jiachun , Lu Han , Huang Chenlingzi , Shu Shanrong 
Published: October 2021

Abstract
Objective: To establish a reliable nomogram model to predict the recurrence rate of ovarian cancer after surgery. Methods: We retrospectively reviewed 216 patients diagnosed with ovarian cancer in our hospital, of which 164 cases were considered valid. Logistic regression model was used to analyze the possible predictors. After that, a nomogram model based on those significantly related predictors was established. We used the bootstrap to internally validate the predictive ability of the nomogram model and used the decision curve analysis (DCA) to compare the performance of the FIGO stage with this model. Results: The nomogram included seven significant recurrence predictors: age, histology type, FIGO stage, omentum involvement, lymphovascular space invasion (LVSI), liver metastasis, and serum CA125. The measurement values for accuracy were Brier score 0.131, correction slope 1.00, and c-index 0.870. which demonstrated this model had a good predictive ability. Compared with the FIGO stage, this hybrid model is more superior in predicting recurrence risk in ovarian cancer patients. Conclusions: We developed and validated a non-invasion and user-friendly nomogram model to predict the recurrence risk of patients with ovarian cancer after surgery.
Aizoon Extract As a Novel Eco-friendly Corrosion Inhibitor For Stainless Steel430 in HCl Solution
Authors: Molouk Ahmed F. , Atia Mohamed F. , Fouda Abd El-Aziz  S. 
Published: October 2021

Abstract
Aizoon extract used as anti-corrosion for stainless steel430 (SS430) in 2M hydrochloric acid solution. The mass reduction, electrochemical impedance, and potentiodynamic polarization were carried out to demonstrate the performance of Aizoon extract as corrosion resistance for SS430. Polarization revealed that the Aizoon extract is mixed type inhibitor with superiority to inhibiting the cathodic reaction. The inhibition percentage reaches 93% at 300 ppm extract. Adsorption of the extract on SS430 surface is regular with Langmuir adsorption model. Thermodynamic factors for adsorption and activation processes for SS430 dissolution were estimated and discussed. Furthermore, the SS430 surface is characterized using different techniques. The surface morphology of SS430 was tested utilizing several techniques. The experimental data were supported by the theoretical data.
Understanding Saffron Biology using Omics- and Bioinformatics Tools- A Step Towards Genome Modified Crocus sp.
Authors: Husaini Amjad M. , Haq Syed Anam ul , Jiménez Alberto José López 
Published: October 2021

Abstract
Saffron is a unique plant in many respects and its cellular processes are regulated at multiple levels. The genetic makeup in the form of eight chromosome triplets (2n = 3x = 24) with a haploid generic content (genome size) of 3.45 Gbp is decoded into different types of RNA by transcription. The RNA then translates into peptides and functional proteins, sometimes involving post-translational modifications too. The interactions of genome, transcriptome, proteome and other regulatory molecules ultimately result in the complex set of primary and secondary metabolites of saffron metabolome. These complex interactions manifest in the form of a set of traits ‘phenome’ peculiar to saffron. The phenome responds to the environmental changes occurring in and around saffron and modify its response in respect of growth, development, disease response, stigma quality, apocarotenoid biosynthesis, etc. Understanding these complex relations between different yet interconnected biological activities is quite challenging in saffron where classical genetics has a very limited role owing to its sterility, and the whole genome sequencing has not been done. Omics-based technologies are immensely helpful in overcoming these limitations and develop a better understanding of saffron biology. In addition to creating a comprehensive picture of the molecular mechanisms involved in apocarotenoid synthesis, stigma biogenesis, corm activity, flower development, etc. omics-technologies will ultimately lead to the engineering of saffron plants with improved phenome. In this review, we discuss the role of omics-technologies and bioinformatics tools in studying saffron biology, and in its improvement.
Associations Between Corpus Callosum Damage, Clinical Disability, and Surface-Based Homologous Inter-Hemispheric Connectivity in Multiple Sclerosis
Authors: Russo Andrew W. , Stockel Kirsten E. , Tobyne Sean M. , Ngamsombat Chanon , Brewer Kristina , Nummenmaa Aapo , Huang Susie Y. , Klawiter Eric C. 
Published: October 2021

Abstract
Axonal damage in the corpus callosum is prevalent in multiple sclerosis (MS). Although callosal damage is associated with disrupted functional connectivity between hemispheres, it is unclear how this relates to cognitive and physical disability. We investigated this phenomenon using advanced measures of microstructural integrity in the corpus callosum and surface-based Homologous Inter-hemispheric Connectivity (sHIC) in the cortex. We found that sHIC was significantly decreased in primary motor, somatosensory, visual, and temporal cortical areas in a group of 36 participants with MS (29 relapsing-remitting, 4 secondary progressive MS, and 3 primary progressive MS) compared with 42 healthy controls (cluster level, p < 0.05). In participants with MS, global sHIC correlated with fractional anisotropy and restricted volume fraction in the posterior segment of the corpus callosum (r = 0.433, p = 0.013; r = 0.325, p = 0.021). Lower sHIC, particularly in somatomotor and posterior cortical areas, was associated with cognitive impairment and higher disability scores on the Expanded Disability Status Scale (EDSS). We demonstrated that higher levels of sHIC attenuated the effects of posterior callosal damage on physical disability and cognitive dysfunction, as measured by the EDSS and Brief Visuospatial Memory Test-Revised (interaction effect, p < 0.05). We also observed a positive association between global sHIC and years of education (r = 0.368, p = 0.018), supporting the phenomenon of “brain reserve” in MS. Our data suggests that preserved sHIC helps prevent cognitive and physical decline in MS.
Features of Sepsis With Worse Outcomes in the ICU Admissions: a Cohort Study From Quick Diagnostic Tests
Authors: Tong Dao-Ming. , Zhou Ye-Ting. , Wang Shao-Dan. , Wang Guang-Sheng. , Wang Yuan-Wei. , Wang Ying. , Zhou Jin-Jin. 
Published: October 2021

Abstract
Background: Sepsis is still a global public health priority. We aimed to investigate the features of sepsis with worse outcomes in a single ICU of China..Methods: We enrolled patients with acute critically ill with sepsis from ICU in China (Jan 1, 2018 to Nov 30, 2019). All patients underwent quick diagnostic tests before and after on admission. We collected data on the features of sepsis cases from hospital medical records and follow-up information. Outcomes were compared between patients who were survivors and those who were not.Results: Of 520 ICU admissions, 214 (41.2%) critically ill adults with sepsis were analyzed. The median age was 66 years (range 18-91 years) and 140 (65.4%) patients were males. 144 (78.3%) community-acquired pneumonia in 184 pneumonia cases were identified by quick chest CT and need mechanically ventilation in ICU. The rate of community- acquired sepsis was 73.8% (158/214) and was associated with a high risk of dynamic profile of inflammatory mediators for nonsurvivors. The initial common symptoms 0f sepsis were fever (42.5%), altered mental status/delirium (41.1%), acute coma (34.1%), and cough/dyspnea (29.9%). Based on data with significant univariate at initial 24 hours in ICU, the multivariate logistic analysis revealed a higher SIRS score (OR,4.7; 95% CI, 2.004-14.37), a higher SOFA score which mainly showed higher prevalent lungs and brain failure (OR, 1.7; 95% CI, 1.299- 2.298), and a lower GCS score (OR, 0.8; 95% CI, 0.673- 0.987) were established as early risk factors for sepsis in nonsurvivors. The mortality of sepsis was 55.6% at 28 days.Conclusions and relevance: Sepsis cases are mainly from community-acquired pneumonia. Severe SIRS and lungs/brain failure are related to the high mortality of sepsis.
An Uncharacterized Protein from the Metagenome with no Obvious Homology to known Lipases Shows Excellent Alkaline Lipase Properties and Potential Applications in the Detergent Industry
Authors: Li Gang , Xiao Yue , Liu Yi-De , Yuan Ge , Mao Run-Qian 
Published: October 2021

Abstract
A novel lipase, Lip486, which has no obvious homology with known lipases, was discovered using functional metagenomics technology. Phylogenetic tree analysis suggested that the enzyme belongs to a new subfamily called lipolytic enzyme family II. To explore the enzymatic properties, lip486 was expressed heterologously and efficiently in Escherichia coli. The recombinant enzyme displayed the highest activity on the substrate p-nitrophenyl caprate with a carbon chain length of 10, and its optimum temperature and pH were 53 °C and 8.0, respectively. The recombinant Lip486 showed good activity and stability in strong alkaline and medium-low -temperature environments. The results of compatibility and soaking tests showed that the enzyme had good compatibility with 4 kinds of commercial detergents, and an appropriate soaking time could further improve the enzyme activity. Oil stain removal test results for a cotton cloth indicated that the washing performance of commercial laundry detergent supplemented with Lip486 was further improved. In addition, as one of the smallest lipases found to date, Lip486 also has the advantages of high yield, good stability and easy molecular modification. These characteristics reflect the good application prospects for Lip486 in the detergent and other industries in the future.
A Novel Defined Pyroptosis-Related Gene Signature For Predicting the Prognosis of Prostate Cancer
Authors: Hu Ding , Cao Qingfei , Tong Ming , Li Zizhi , Huang Weichao , Jin Yanyang , Tong Guangquan , Wang Yutao , Li Pengfei , Zhang Huashan 
Published: October 2021

Abstract
Background: Pyroptosis can not only inhibit the occurrence and development of tumors but also develop a microenvironment conducive to cancer growth. However, pyroptosis research in prostate cancer (PCa) has rarely been reported.Methods: The expression profile and corresponding clinical data were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Patients were divided into different clusters using consensus clustering analysis, and differential genes were obtained. We developed and validated a prognostic signature for biochemical recurrence (BCR) of PCa using univariate Cox analysis, LASSO-COX analysis, Kaplan-Meier (K-M) survival analysis, and time-dependent receiver operating characteristics (ROC) curves.Results: The expression levels of most pyroptosis-related genes (PRGs) are different not only between normal and tumor tissues but also between different clusters. Cluster2 patients have a better prognosis than cluster1 patients, and there are significant differences in immune cell content and biological pathway between them. Based on the classification of different clusters, we constructed an eight genes signature that can independently predict the progression-free survival (PFS) rate of a patient, and this signature was validated using a GEO data set (GSE70769). Finally, we established a nomogram model with good usability.Conclusions: In this study, PRGs were used as the starting point and based on the expression profile and clinical data, a prognostic signature with a high predictive value for biochemical recurrence (BCR) following radical prostatectomy (RP) was finally constructed, and the relationship between pyroptosis, immune microenvironment, and PCa was explored, providing important clues for future research on pyroptosis and immunity.