bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of responsible management education: practices, outcomes and challenges
Authors: Abdelgaffar Hala A. 
Published: November 2021

PurposeResearch on management education (ME) over the past 2 decades signals a growing level of concern in response to increasing societal demands for ethical, responsible and sustainable considerations in management decisions in light of the current economic situation. The purpose of this paper is to review extant literature on responsible management education (RME) over the past decade.Design/methodology/approachThe author carried out a systematic literature review of peer-reviewed publications, which were mapped and analysed according to the following six categories: (1) types of papers, (2) geographical context, (3) RME purpose, (4) strategies, (5) intended outcomes and (6) challenges. The analysis resulted in a descriptive overview of article content and synthesis of review data categorised by topical focus.FindingsAnalysis of the review sample reveals how scholarly interest in RME has accelerated over the last decade. This is accompanied by a growing institutionalisation and development of RME. The descriptive analysis indicates that the vast majority of publications focus on RME implementation strategies, mostly focussing on on-campus – curricular, pedagogical and operational – changes and the unique experiences of particular schools. Recent publications reveal interest in how RME can respond to triple bottom line (TBL) concerns that benefit the wider society and to sustainable development (SD) goals that target the local and global community. A budding interest is revealed in examining the perceptions of diverse stakeholder groups of sustainability requirements in RME curricula to create relevant and practical content.Originality/valueThis paper contributes to the adoption and/or development of RME.
Users' needs and expectations on information services provided in libraries: case of four public university libraries from the western region of Kenya
Authors: Nyakweba Irene , Bukirwa Joyce Muwanguzi , Sendikadiwa Eunice , Ratanya Felicitas Ciabere 
Published: November 2021

PurposeThe purpose of this study is to assess the users' needs and expectations on information services provided in libraries, in four public universities from the western region of Kenya. The study explores the extent to which the libraries address users' needs and expectations examining the challenges being encountered, remedies and best practices put in place to mitigate the challenges. The level of users satisfaction towards the information services provided is also examined.Design/methodology/approachStructured questionnaires were distributed among undergraduates (384) and lecturers (86), where 342 were successfully filled and returned, giving a response rate of 73%. The study interviewed ten library staff revealing their views in addressing users' needs and expectations in respective libraries. Collected data were analysed descriptively using statistical methods and presented in figures and tables. Qualitative data were analysed in narrative form.FindingsMajority of users had a positive perception towards the library, while others indicated that their needs were yet to be meet. The study noted the poor state of affair with inadequacies in information materials infrastructure, dwindling budget, facilities and unskilled personnel. The study recommended the need for additional library budget to facilitate acquisition of additional and up-to-date information resources and facilities.Originality/valueThe concept of user needs and expectations has been widely discussed in developed countries. Identifying and understanding users’ requirements in the context of public libraries in developing countries would start up constructive trends towards building useable collections.
Paper development in qualitative accounting research: bringing social contexts to life
Authors: Ahrens Thomas 
Published: November 2021

PurposeExpanding on an invited talk at the 1st Paper Development Workshop of the Qualitative Management Accounting Research Group, the purpose of this study is to offer some suggestions for developing qualitative accounting papers. Emphasis is put on the potential of qualitative research to situate evocative accounts of the organisational functionings of accounting in their wider social contexts.Design/methodology/approachTo think about paper development as an exercise in communicating worthwhile findings to the readership by interweaving the researcher’s impressions of the field, recorded field material and different social theories to create qualitative accounting scholarship.FindingsQualitative accounting papers can, through the use of different theories, show the embedding of the organisational in the social. Development of qualitative accounting papers is an achievement that emerges in the process of writing.Practical implicationsOutlines five summary recommendations for paper development.Originality/valueReflects on paper development designed to create qualitative accounting research.
Developing youth justice policy and programme design in Australia
Authors: Butcher Luke , Day Andrew , Miles Debra , Kidd Garry , Stanton Steven 
Published: November 2021

AbstractThe national Closing the Gap reform provides a mandate for mainstream organisations to undergo structural transformation to better address the needs and concerns of Aboriginal and Torres Strait Islander communities. In the criminal justice sector, the reform resonates strongly with ongoing discussions about how both policy and practice can address the significant over‐representation of Aboriginal people across the criminal justice system. One way that structural transformation can occur is through the genuine involvement of Aboriginal knowledge holders and communities in policy development. This study illustrates how this might happen in relation to youth justice policy and programme design. Eighteen Aboriginal community members from a town in rural New South Wales participated in a series of interviews relevant to the Closing the Gap target. Qualitative content analysis was used to identify four key themes relevant to the development of justice policy: supporting cultural identity in a post‐colonial context; articulating strengths and resources which can be mobilised in the community; the centrality of poverty to offending; and responding to intergenerational trauma. The study illustrates how non‐Indigenous policymakers and practitioners might approach the task of engagement and consultation by identifying Aboriginal knowledge as a legitimate epistemic resource that they can draw upon to guide the ongoing development of evidence‐based policy and programmes.
Imagining genomic medicine futures in primary care: General practitioners’ views on mainstreaming genomics in the National Health Service
Authors: Mwale Shadreck , Farsides Bobbie 
Published: November 2021

AbstractGenomic medicine has captured the imaginations of policymakers and medical scientists keen to harness its health and economic potentials. In 2012, the UK government launched the 100,000 Genomes Project to sequence the genomes of British National Health Service (NHS) patients, laying the ground for mainstreaming genomic medicine in the NHS and developing the UK’s genomics industry. However, the recent research and reports from national bodies monitoring genomic medicine's roll‐out suggest both ethical and practical challenges for health‐care professionals. Against this backdrop, this paper, drawing on qualitative research interviews with general practitioners (GPs) and documentary analysis of policy, explores GPs’ views on mainstreaming genomic medicine in the NHS and implications for their practice. Analysing the NHS’s genomic medicine agenda as a ‘sociotechnical imaginary’, we demonstrate that whilst sociotechnical imaginaries are construed as collectively shared understandings of the future, official visions of genomic medicine diverge from those at the forefront of health‐care service delivery. Whilst policy discourse evokes hope and transformation of health care, some GPs see technology in formation, an unattainable ‘utopia’, with no relevance to their everyday clinical practice. Finding space for genomics requires bridging the gap between ‘work as imagined’ at the policy level and ‘work as done’ in health‐care delivery.
Maternal and neonatal outcomes following waterbirth: a cohort study of 17 530 waterbirths and 17 530 propensity score‐matched land births
Authors: Bovbjerg ML , Cheyney M , Caughey AB 
Published: November 2021

ObjectiveInvestigate maternal and neonatal outcomes following waterbirth.DesignRetrospective cohort study, with propensity score matching to address confounding.SettingCommunity births, United States.SampleMedical records‐based registry data from low‐risk births were used to create waterbirth and land birth groups (n = 17 530 each), propensity score‐matched on >80 demographic and pregnancy risk covariables.MethodsLogistic regression models compared outcomes between the matched waterbirth and land birth groups.Main outcome measuresMaternal: immediate postpartum transfer to a hospital, any genital tract trauma, severe (3rd/4th degree) trauma, haemorrhage >1000 mL, diagnosed haemorrhage regardless of estimated blood loss, uterine infection, uterine infection requiring hospitalisation, any hospitalisation in the first 6 weeks. Neonatal: umbilical cord avulsion; immediate neonatal transfer to a hospital; respiratory distress syndrome; any hospitalisation, neonatal intensive care unit (NICU) admission, or neonatal infection in the first 6 weeks; and neonatal death.ResultsWaterbirth was associated with improved or no difference in outcomes for most measures, including neonatal death (adjusted odds ratio [aOR] 0.56, 95% CI 0.31–1.0), and maternal or neonatal hospitalisation in the first 6 weeks (aOR 0.87, 95% CI 0.81–0.92 and aOR 0.95, 95% CI 0.90–0.99, respectively). Increased morbidity in the waterbirth group was observed for two outcomes only: uterine infection (aOR 1.25, 95% CI 1.05–1.48) (but not hospitalisation for infection) and umbilical cord avulsion (aOR 1.57, 95% CI 1.37–1.82). Our results are concordant with other studies: waterbirth is neither as harmful as some current guidelines suggest, nor as benign as some proponents claim.Tweetable abstractNew study demonstrates #waterbirth is neither as harmful as some current guidelines suggest, nor as benign as some proponents claim. @TheUpliftLab @BovbjergMarit @31415926abc @NICHD_NIH.
Applications of bioactive compounds extracted from olive industry wastes: A review
Authors: Madureira Joana , Margaça Fernanda M. A. , Santos‐Buelga Celestino , Ferreira Isabel C. F. R. , Verde Sandra Cabo , Barros Lillian 
Published: November 2021

AbstractThe wastes generated during the olive oil extraction process, even if presenting a negative impact for the environment, contain several bioactive compounds that have considerable health benefits. After suitable extraction and purification, these compounds can be used as food antioxidants or as active ingredients in nutraceutical and cosmetic products due to their interesting technological and pharmaceutical properties. The aim of this review, after presenting general applications of the different types of wastes generated from this industry, is to focus on the olive pomace produced by the two‐phase system and to explore the challenging applications of the main individual compounds present in this waste. Hydroxytyrosol, tyrosol, oleuropein, oleuropein aglycone, and verbascoside are the most abundant bioactive compounds present in olive pomace. Besides their antioxidant activity, these compounds also demonstrated other biological properties such as antimicrobial, anticancer, or anti‐inflammatory, thus being used in formulations to produce pharmaceutical and cosmetic products or in the fortification of food. Nevertheless, it is mandatory to involve both industries and researchers to create strategies to valorize these byproducts while maintaining environmental sustainability.
Tenebrio molitoras a source of interesting natural compounds, their recovery processes, biological effects, and safety aspects
Authors: Errico Simona , Spagnoletta Anna , Verardi Alessandra , Moliterni Stefania , Dimatteo Salvatore , Sangiorgio Paola 
Published: November 2021

AbstractNowadays, it is urgent to produce in larger quantities and more sustainably to reduce the gap between food supply and demand. In a circular bioeconomy vision, insects receive great attention as a sustainable alternative to satisfy food and nutritional needs. Among all insects,Tenebrio molitor(TM) is the first insect approved by the European Food Safety Authority as a novel food in specific conditions and uses, testifying its growing relevance and potential. This review holistically presents the possible role of TM in the sustainable and circular solution to the growing needs for food and nutrients. We analyze all high value‐added products obtained from TM (powders and extracts, oils and fatty acids, proteins and peptides, and chitin and chitosan), their recovery processes (evaluating the best ones in technical and environmental terms), their nutritional and economical values, and their biological effects. Safety aspects are also mentioned. TM potential is undoubted, but some aspects still need to be discussed, including the health effects of substances and microorganisms in its body, the optimal production conditions (that affect product quality and safety), and TM capacity to convert by‐products into new products. Environmental, economic, social, and market feasibility studies are also required to analyze the new value chains. Finally, to unlock the enormous potential of edible insects as a source of nutritious and sustainable food, it will be necessary to overcome the cultural, psychological, and regulatory barriers still present in Western countries.
Efficacy of medium cut‐off dialyzers and comparison with high‐flux dialyzers in patients on maintenance hemodialysis: A systematic review and meta‐analysis
Authors: Yang Jia , Ke Guibao , Liao Yuanjiang , Guo Yong , Gao Xiaoling 
Published: November 2021

AbstractMedium cut‐off (MCO) dialyzers were designed to provide better clearance of uremic toxins. We conducted a meta‐analysis comparing MCO with high‐flux (HF) dialyzers for the effect on uremic toxins in maintenance hemodialysis (HD) patients. Five databases were systematically searched for relevant studies and nine studies were identified finally. Reduction ratio (RR) of urea, urea, creatinine, β2‐macroglobulin (β2‐MG), kappa free light chain (κFLC), and lambda FLC (λFLC) levels were not significantly different between MCO and HF dialyzers. But RR of β2‐MG, κFLC, and λFLC were greater for MCO than HF dialyzers. MCO dialyzers could better reduce tumor necrosis factor‐α (TNF‐α) levels. Subgroup analysis stratified by study design indicated that in randomized controlled trial (RCT) studies, albumin levels was lower in MCO than HF dialyzers group, but the two dialyzers treatments were equivalent in non‐RCT subgroup. Compared with HF dialyzers, MCO dialyzers provided higher middle‐molecules uremic toxins clearance and obviously reduced TNF‐α levels.
Efficiency of calcined Aluminum‐Magnesium layered double hydroxide for adsorption of aflatoxin M1 from solution and matrix of milk
Authors: Jahanmard Elham , Keramat Javad , Nasirpour Ali , Emadi Rahmatollah 
Published: November 2021

AbstractDetoxification of aflatoxin M1 from solution and milk using layered double hydroxides was investigated. The Aluminum‐Magnesium layered double hydroxide (Al‐Mg LDH) and Iron‐Magnesium layered double hydroxide (Fe‐Mg LDH) were selected in their calcined and non‐calcined forms to evaluate the effect of the calcination on detoxification. These materials were produced using the co‐precipitation method. Preliminary adsorption tests confirmed use of Al‐Mg LDH as the selected adsorbent. Characteristics of the adopted adsorbent were studied and confirmed by XRD, FTIR, SEM, and BET methods. Effects of the initial content of aflatoxin, amount of the adsorbents and detoxification time were investigated. Influence of the adsorbents on the nutritional aspects of milk were also studied. The study showed that while the non‐calcined forms of LDH were not able to adsorb aflatoxin M1 more than 23%, the calcined form of Al‐Mg LDH exhibited 100% adsorption in the solutions and about 70–100% in the contaminated milk samples. The reason is pointed to the fact that calcination of Al‐Mg LDH considerably increased the surface area, the total pore volume, and the pore size of the material. Multivariate regression analysis and calculation of the Pearson correlation factor showed that the remained aflatoxin at each time was more strongly correlated with the initial amount of aflatoxin and the elapsed time and less strongly with the amount of the adsorbent. It was found that the adsorption isotherms fitted to the Freundlich equation with a high adsorption capacity of 555.5 mg g−1.Practical ApplicationThis study is focused on examining ability of layered double hydroxides (LDH) for adsorbing AFM1. LDHs are promising layered materials due to some of their interesting characteristics, such as ease of synthesis and uniqueness of structure. In practice, results of this study can be used for detoxification of aflatoxin, especially in milk, at high efficiency in shorter time durations.
LncRNA and mRNA expression associated with myasthenia gravis in patients with thymoma
Authors: Ke Ji , Du Xin , Cui Jian , Yu Lei , Li Hui 
Published: November 2021

AbstractObjectivePathological alterations of the thymus are observed in the majority of patients with myasthenia gravis (MG). To explore the potential mechanisms of these alterations, we performed a transcriptome analysis and measured co‐expression of aberrant long non‐coding RNAs (lncRNAs) and messenger RNAs (mRNAs).MethodsRNA was extracted from eight patients with thymoma, five of whom had MG. Transcriptome profiles were acquired through mRNA and lncRNA microarray analysis. Quantitative reverse transcription polymerase chain reaction was used to verify the results of the microarray analysis. LncRNAs co‐expressed with mRNA were analyzed with Pearson's coefficient. Next, cis‐regulated and trans‐regulated target genes were predicted. The functions of aberrant lncRNAs were explored on the basis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of target mRNAs.ResultsThe comparative microarray analysis identified 4360 lncRNAs and 2545 mRNAs with significant differential expression. The most significant GO enrichment terms were phosphoric ester hydrolase activity, phosphatase activity, and hydrolase activity, which were assigned as molecular functions. Regulation of endosome size was the most significant GO enrichment term assigned as a biological process, and Golgi apparatus was the most significant GO enrichment term assigned as cellular component. The reliability prediction terms of KEGG included calcium signaling pathway, glycosphingolipid biosynthesis, and caffeine metabolism.ConclusionMG‐positive thymoma is associated with overactive biological processes and molecular functions, especially dephosphorylation and hydrolysis, which may affect thymocyte survival during selection in the thymus.
Estimating allometric energy allocation between somatic and gonadic growth
Authors: Shimadzu Hideyasu , Wang Hui‐Yu 
Published: November 2021

Abstract

Quantifying growth patterns and energy allocation strategies is essential to comprehend the biological characteristics of organisms and their interactions with broader biological communities in which they reside. Mathematical models, such as mono‐ and diphasic allometric energy‐based growth models, play a pivotal role in delineating such body growth patterns. However, modelling approaches often face some major challenges that stem from both model nonlinearity and data limitation in practice.

The present study investigates the nature of the challenges and develops a flexible diphasic allometric growth model. The proposed modelling framework offers an effective parameter estimation approach directly built upon statistical smoothing techniques and numerical optimisation methods.

The simulation study undertaken demonstrates that the proposed approach can provide accurate parameter estimates. The illustrative example analyses the individual body and gonadic weight of subtropical cutlassfish Trichiurus japonicus from the cooler northern and warmer southern coasts of Taiwan. The results reveal the linear growth of fish in the south compared with those in the north, which distinctive growth pattern results from the lower dependency to body mass in the somatic and gonadic growth.

The proposed unified modelling framework offers new advances in growth modelling to shed light upon the intraspecific life‐history strategies, quantifying growth patterns and energy allocation strategies.
Ethanol attenuates presentation of cytotoxic T‐lymphocyte epitopes on hepatocytes of HBV‐infected humanized mice
Authors: Ganesan Murali , Wang Weimin , Mathews Saumi , Makarov Edward , New‐Aaron Moses , Dagur Raghubendra Singh , Malo Antje , Protzer Ulrike , Kharbanda Kusum K. , Casey Carol A. , Poluektova Larisa Y. , Osna Natalia A. 
Published: November 2021

AbstractBackground and AimsApproximately 3.5% of the global population is chronically infected with Hepatitis B Virus (HBV), which puts them at high risk of end‐stage liver disease, with the risk of persistent infection potentiated by alcohol consumption. However, the mechanisms underlying the effects of alcohol on HBV persistence remain unclear. Here, we aimed to establish in vivo/ex vivo evidence that alcohol suppresses HBV peptides‐major histocompatibility complex (MHC) class I antigen display on primary human hepatocytes (PHH), which diminishes the recognition and clearance of HBV‐infected hepatocytes by cytotoxic T‐lymphocytes (CTLs).MethodsWe used fumarylacetoacetate hydrolase (Fah)‐/‐, Rag2‐/‐, common cytokine receptor gamma chain knock‐out (FRG‐KO) humanized mice transplanted with human leukocyte antigen‐A2 (HLA‐A2)‐positive hepatocytes. The mice were HBV‐infected and fed control and alcohol diets. Isolated hepatocytes were exposed ex vivo to HBV 18‐27‐HLA‐A2‐restricted CTLs to quantify cytotoxicity. For mechanistic studies, we measured proteasome activities, unfolded protein response (UPR), and endoplasmic reticulum (ER) stress in hepatocytes from HBV‐infected humanized mouse livers.Results and ConclusionsWe found that alcohol feeding attenuated HBV core 18‐27‐HLA‐A2 complex presentation on infected hepatocytes due to the suppression of proteasome function and ER stress induction, which diminished both the processing of HBV peptides and trafficking of HBV‐MHC class I complexes to the hepatocyte surface. This alcohol‐mediated decrease in MHC class I‐restricted antigen presentation of the CTL epitope on target hepatocytes reduced the CTL‐specific elimination of infected cells, potentially leading to HBV‐infection persistence, which promotes end‐stage liver disease outcomes.