bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF THE CHUVASH ATHLETES’ PERFORMANCES AT THE OLYMPIC GAMES FROM 1952 TO 2016
Authors: Пьянзин Андрей Иванович , Пьянзина Надежда Николаевна 
Published: April 2021

На сегодняшний день имеет место противоречие между большим объемом эмпирического и статистического материала по достижениям чувашских спортсменов в крупнейших международных соревнованиях и недостаточно глубоким их анализом, лежащим в основе выявления закономерностей и перспектив развития спорта в республике. Целью исследования является выявление динамики и закономерностей участия спортсменов Чувашской Республики в составе сборной команды страны на Олимпийских играх 1952-2016 гг. Методы исследования: теоретический анализ исторической и справочной литературы по теме исследования, анализ документальных материалов, методы математической статистики. В советский период наибольшее число участников Олимпийских игр среди спортсменов Чувашской Республики (по 4 человека) приходится на игры 1972 и 1976 гг. Самыми успешными можно признать выступления спортсменов Чувашской Республики на Олимпийских играх 1968, 1976 и 1980 гг. Наиболее высокое среднее место приходится на бокс, фехтование, командную велогонку, борьбу классическую. В постсоветский период представительство спортсменов Чувашской Республики в составе Олимпийской сборной России заметно увеличилось и составило по 10 человек на играх в 2000 и 2004 гг., 9 человек на играх в 2008 г. Можно выделить 20-летний период успешного выступления спортсменов Чувашской Республики на Олимпийских играх - с 1992 по 2012 гг. Наиболее высокое среднее место приходится на спортивную гимнастику, бег 3000 м с препятствиями.
Today, there is a contradiction between a large volume of empirical and statistical material on the achievements of athletes of the Chuvash Republic in major international competitions and insufficient analysis, which is the basis for identifying the regularities and prospects for the development of sports in the republic. The aim of the study is to identify the dynamics and patterns of participation of athletes of the Chuvash Republic in the national team at the Olympic Games of 1952-2016. The research methods are theoretical analysis of historical and reference literature on the research topic, analysis of documentary materials, methods of mathematical statistics. In the Soviet period, the largest number of participants in the Olympic Games among athletes of the Chuvash Republic (4 people) was in the 1972 and 1976 Games. The performances of the Chuvash athletes at the Olympic Games of 1968, 1976 and 1980 can be considered the most successful. The most striking results were achieved in boxing, fencing, team cycling, and Greco-Roman wrestling. In the post-Soviet period, the representation of athletes of the Chuvash Republic in the Russian Olympic team has noticeably increased and amounted to 10 people at the games in 2000 and 2004, 9 people - at the games in 2008. A 20-year period from 1992 to 2012 can be considered most successful. The greatest results were achieved in gymnastics and steeplechase.
MODEL OF PEDAGOGICAL INTERACTION OF SOCIAL INSTITUTIONS IN FORMATION OF PATRIOTIC CULTURE AT STUDENTS
Authors: Тимофеев Андрей Александрович 
Published: April 2021

Личностные характеристики и нравственные ориентиры подрастающего поколения определяются сложившимися и принятыми социумом моральными нормами и приоритетами. Ведущие ориентиры поведения и жизнедеятельности как система ценностей обусловливают поведение человека и его поступки, формируясь с детского возраста на основе духовного и социально ориентированного воспитания. Особое место в системе ценностей отводится патриотизму - категории нравственного контура, которая оказывает существенное влияние на личность и распространяется на все население страны в контексте социально-экономической жизнедеятельности и безопасности. Поиск новых форм и ресурсов патриотического воспитания, способных привлечь молодежь к социально активной созидательной деятельности, определяет тему исследования. Авторская структурно-функциональная модель представлена через описание совокупности блоков (нормативно-целевого, теоретико-методологического, содержательного, организационно-технологического и диагностическо-результативного), последовательно раскрывающих процесс педагогического взаимодействия социальных институтов в формировании патриотической культуры учащейся молодежи. Статья предназначена для сотрудников сферы общего и дополнительного образования, работников общественных организаций, профильных ведомств, занимающихся вопросами патриотического воспитания молодежи.
Personal qualities and moral guide of younger generation are conditioned by accepted moral standards. The key guidelines of behavior and living as a system of values determine the behavior of a person since childhood basing on spiritual and society-oriented education. Patriotism is given a special place in the system of values. It has a significant influence on the individual and extends to the entire population of the country in the context of socio-economic life and security. The search for new forms and resources of patriotic education that can attract young people to socially active creative activities determines the topic of the study. The author’s structural-functional model is presented through a description of a set of blocks (normative-target, theoretical-methodological, substantive, organizational-technological and diagnostic-effective), which consistently reveals the process of pedagogical interaction of social institutions in the formation of patriotic culture at young students. The article is intended for specialists of general and additional education, employees of public organizations, specialized departments dealing with issues of patriotic education of youth.
Safe Prescription for Junior Doctors in Accordance with All Wales Prescribing Standards
Authors: Naz Mavra , Khan Adil Umer , Aslam Muhammad Usama , Ameer Muhammad Kamran , Mehboob Faiza 
Published: April 2021

Background: Prescribing errors are quite common and according to one estimate out of 100 patients admitted into UK hospitals 15 will have some form of prescribing error in their records. It is a general understanding that most of the time these errors are made due to lack of awareness. Severity of these errors can range from minor to major mistakes that can lead to fatal results.
Materials and Methods: A simplified anonymous approach of identifying these errors and then using a step wise approach to educate the prescribers’ especially junior doctors can be quite fruitful in reducing these errors. Unfortunately there are not many studies or projects available to back our proposal however these seems a logical way forward and is exactly what we have shown in our study.
Results: We performed a prospective snapshot study involving 100 inpatients to get baseline measurements. The errors and mistakes were identified and fed back to the junior doctors in an anonymous manner. Clear & legible writing, frequency of use, responsible consultant name, allergy box filled, VTE assessment, oxygen prescribing and labeling of medication discontinuation were the most common negligence identified. At the same time junior doctors were reminded of local prescription standards and guidelines which usually don’t form part of induction.
Conclusion: Multiple deficient areas were identified during this audit like legible writing, dosage frequency, VTE prophylaxis and oxygen prescription. It was highlighted to junior doctors how important are these components as they play a key role in patient getting better after medical review. Above mentioned steps did improve prescription errors to an extent, but aim should be to achieve 100% results. Repeated reminders are important in this case as that helps to improve practice and avoid clinical accidents.
MODEL OF PSYCHOLOGICAL INFLUENCE IN SOCIAL MEDIA
Authors: Занковский А. Н. , Латынов В. В. 
Published: April 2021

Статья посвящена изложению предложенной авторами модели психологического воздействия в социальных сетях. Основанием модели послужили теоретические подходы, направленные на понимание особенностей реагирования отдельного человека, столкнувшегося с потоком информации в социальных сетях, а также концепции, ориентированные на анализ роли социальной идентичности человека и его социального окружения в процессах воздействия. Описаны элементы модели: субъект воздействия, объект воздействия, средства, эффекты и контекст воздействия. Охарактеризованы четыре группы факторов эффективности психологического воздействия в социальных сетях: характеристики субъекта воздействия, особенности средств и контекста воздействия, характеристики объекта воздействия.
The article is devoted to the presentation of the model of psychological influence on social media proposed by the authors. The model is based on theoretical approaches aimed at understanding the characteristics of the individual's response to the flow of information in social networks, as well as concepts focused on analyzing the role of a person's social identity and social environment in the impact processes. The elements of the model are described: subject of influence, object of influence, means, effects and context of influence. Four groups of factors of the effectiveness of psychological influence in social media are characterized: characteristics of the subject of influence, features of the means of influence and context of influence, characteristics of the object of influence.
THE RELATIONSHIP OF LIFE AND VALUE ORIENTATIONS OF ENTREPRENEURS AND THE CHARACTERISTICS OF THEIR ECONOMIC SELF-DETERMINATION
Authors: Позняков В.П. 
Published: April 2021

Представлены результаты теоретико-эмпирического исследования взаимосвязей смысложизненных и ценностных ориентаций личности предпринимателей и показателей их экономического самоопределения. Результаты корреляционного анализа показали наличие множественных статистически значимых связей смысложизненных ориентаций предпринимателей с показателями их экономического самоопределения. Наибольшее число обнаружили шкалы «Процесс жизни или интерес и эмоциональная насыщенность жизни» и «Локус контроля - жизнь или управляемость жизни». Высокая значимость ценностей, объединенных Ш. Шварцем в блоки «открытость изменениям» (самостоятельность и стимуляция) и «самовозвышение» (власть и достижения), в сочетании с высокой значимостью ценности «гедонизм», которая, по Шварцу, составляет отдельный блок и включает элементы как открытости изменениям, так и самовозвышения, которые положительно коррелируют с показателями экономического самоопределения, характеризующимися позитивными оценками своей деловой активности и динамики ее изменения, отношения к конкуренции и риску, собственных возможностей в повышении успешности своего бизнеса и успешности своей предпринимательской деятельности. Результаты исследования подтверждают правомерность рассмотрения смысложизненных и ценностных ориентаций личности в качестве факторов самоопределения предпринимателей.
The article presents the results of a theoretical and empirical study of the interrelationships of the meaning-life and value orientations of the individual entrepreneurs and the indicators of their economic self-determination. The results of the correlation analysis showed the presence of multiple statistically significant relationships between the meaning-of-life orientations of entrepreneurs and indicators of their economic self-determination. The scales "Life process or interest and emotional saturation of life" and "Locus of control - life or manageability of life" found the greatest number of correlations with indicators of economic self-determination. The high importance values, the United Schwartz block "openness to change" (self-direction and stimulation) and "self-exaltation (power and achievement) combined with high significance values "hedonism", which, according to Schwartz, is a separate unit, and includes elements of both openness to change and self-exaltation, is positively correlated with indicators of economic self-determination, characterized by positive assessments of their business activity and the dynamics of its changes, the relationship of competition and risk, their own opportunities to increase the success of their business and the success of their business activities. The results of the study confirm the validity of considering the meaning of life and value orientations of the individual as factors of self-determination of entrepreneurs.
Treatment Modification after Second-Line Failure among People Living with HIV in Asia-Pacific
Authors: Jiamsakul Awachana , Azwa Iskandar , Zhang Fujie , Yunihastuti Evy , Ditangco Rossana , Kumarasamy Nagalingeswaran , Ng Oon Tek , Chan Yu-Jiun , Ly Penh Sun , Choi Jun Yong , Lee Man-Po , Pujari Sanjay , Kiertiburanakul Sasisopin , Chaiwarith Romanee , Merati Tuti Parwati , Sangle Shashikala , Khusuwan Suwimon , Sim Benedict LH , Avihingsanon Anchalee , Do Cuong Duy , Tanuma Junko , Ross Jeremy , Law Matthew ,   the TREAT Asia HIV Observational Database of IeDEA Asia-Pacific
Published: April 2021

Background The World Health Organization recommends continuation with the failing second-line regimen if third-line option is not available. We investigated treatment outcomes among people living with HIV in Asia who continued with failing second-line regimens compared with those who had treatment modifications after failure. Methods Treatment modification was defined as a change of two antiretrovirals, a drug class change or treatment interruption (TI), all for >14 days. We assessed factors associated with CD4 changes and undetectable viral load (UVL <1,000 copies/ml) at 1 year after second-line failure using linear and logistic regression, respectively. Survival time was analysed using competing risk regression. Results Of the 328 patients who failed second-line ART in our cohorts, 208 (63%) had a subsequent treatment modification. Compared with those who continued the failing regimen, the average CD4 cell increase was higher in patients who had a modification without TI (difference =77.5, 95% CI 35.3, 119.7) while no difference was observed among those with TI (difference =-5.3, 95% CI -67.3, 56.8). Compared with those who continued the failing regimen, the odds of achieving UVL was lower in patients with TI (OR=0.18, 95% CI 0.06, 0.60) and similar among those who had a modification without TI (OR=1.97, 95% CI 0.95, 4.10), with proportions of UVL 60%, 22% and 75%, respectively. Survival time was not affected by treatment modifications. Conclusions CD4 cell improvements were observed in those who had treatment modification without TI compared with those on the failing regimen. When no other options are available, maintaining the same failing ART combination provided better VL control than interrupting treatment.
Amelioration of Graft-versus-Host Disease by Exopolysaccharide from a Commensal Bacterium
Authors: Kalinina Olga , Talley Sarah , Zamora-Pineda Jesus , Paik Wonbeom , Campbell Edward M. , Knight Katherine L. 
Published: April 2021

Abstract
Acute graft-versus-host disease (aGvHD) is a severe, often lethal, complication of hematopoietic stem cell transplantation, and although prophylactic regimens are given as standard pretransplantation therapy, up to 60% of these patients develop aGvHD, and require additional immunosuppressive intervention. We treated mice with a purified probiotic molecule, exopolysaccharide (EPS) from Bacillus subtilis, shortly before and after induction of aGvHD and found that, whereas only 10% of control mice survived to day 80, 70% of EPS-treated mice survived to 80 d. EPS treatment of donor-only mice resulted in ∼60% survival. Using a biosensor mouse model to assess inflammation in live mice during aGvHD, we found that EPS prevented the activation of alloreactive donor T cells. In vitro, EPS did not affect T cells directly but, instead, induced bone marrow–derived dendritic cells (BMDCs) that displayed characteristics of inhibitory dendritic cells (DCs). Development of these BMDCs required TLR4 signaling through both MyD88 and TRIF pathways. Using BMDCs derived from IDO knockout mice, we showed that T cell inhibition by EPS-treated BMDCs was mediated through the suppressive effects of IDO. These studies describe a bacterial molecule that modulates immune responses by inducing inhibitory DCs in a TLR4-dependent manner, and these cells have the capacity to inhibit T cell activation through IDO. We suggest that EPS or EPS-treated DCs can serve as novel agents for preventing aGvHD.
Autoreactivity of Peripheral Helper T Cells in the Joints of Rheumatoid Arthritis
Authors: Sakuragi Takahide , Yamada Hisakata , Haraguchi Akihisa , Kai Kazuhiro , Fukushi Jun-ichi , Ikemura Satoshi , Akasaki Yukio , Fujiwara Toshifumi , Tsushima Hidetoshi , Tsutsui Tomoko , Kondo Masakazu , Yoshikai Yasunobu , Okada Seiji , Nakashima Yasuharu 
Published: April 2021

AbstractAutoreactive CD4 T cells are thought to play pivotal roles in the pathogenesis of rheumatoid arthritis (RA). Recently, a subset of CD4 T cells that express high levels of programmed death-1 (PD-1) but are distinct from follicular helper T cells have been identified in the joints of RA patients and named peripheral helper T (Tph) cells. Because PD-1 is expressed on T cells chronically stimulated with the Ags, we tested a hypothesis that Tph cells are the pathogenic autoreactive CD4 T cells in RA. We found that human Tph cells in RA joints produce proinflammatory effector cytokines, including IFN-γ, TNF-α, and GM-CSF, in addition to B cell–helping cytokines, such as IL-21 and CXCL13. Flow cytometric analysis showed different bias of TCR Vβ usage between PD-1high Tph cells and PD-1low/neg CD4 T cells, including Th1 cells, in the joint or memory CD4 T cells in the peripheral blood, whereas there was little difference between the latter two subsets. In line with this, deep sequencing of TCR demonstrated an overlap of expanded clones between peripheral blood memory CD4 T cells and PD-1low/neg CD4 T cells but not Tph cells in the joint. Interestingly, Tph cells preferentially exhibited autologous MLR in vitro, which required recognition of self–MHC class II and was pronounced by blocking PD-1 signaling. Taken together, these results suggest that Tph cells are the pathogenic autoreactive CD4 T cells in RA, which expand locally in the joints and are regulated by PD-1 signaling.
Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients
Authors: Yan Qihong , Li Pingchao , Ye Xianmiao , Huang Xiaohan , Feng Bo , Ji Tianxing , Chen Zhilong , Li Feng , Zhang Yudi , Luo Kun , Chen Fengjuan , Mo Xiaoneng , Wang Jianhua , Feng Liqiang , Hu Fengyu , Lei Chunliang , Qu Linbing , Chen Ling 
Published: April 2021

Abstract
Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients developing severe illness or even death. Disease severity has been associated with increased levels of proinflammatory cytokines and lymphopenia. To elucidate the atlas of peripheral immune response and pathways that might lead to immunopathology during COVID-19 disease course, we performed a peripheral blood RNA sequencing analysis of the same patient’s samples collected from symptom onset to full recovery. We found that PBMCs at different disease stages exhibited unique transcriptome characteristics. We observed that SARS-CoV-2 infection caused excessive release of inflammatory cytokines and lipid mediators as well as an aberrant increase of low-density neutrophils. Further analysis revealed an increased expression of RNA sensors and robust IFN-stimulated genes expression but a repressed type I IFN production. SARS-CoV-2 infection activated T and B cell responses during the early onset but resulted in transient adaptive immunosuppression during severe disease state. Activation of apoptotic pathways and functional exhaustion may contribute to the reduction of lymphocytes and dysfunction of adaptive immunity, whereas increase in IL2, IL7, and IL15 may facilitate the recovery of the number and function of lymphocytes. Our study provides comprehensive transcriptional signatures of peripheral blood response in patients with moderate COVID-19.
Predictors of acceptance and willingness to pay for the COVID-19 vaccine in the general public of India
Authors: Goruntla Narayana , Chintamani Sai Harshavardhan , Bhanu P , Samyuktha S , Veerabhadrappa Kasturi Vishwanathasetty , Bhupalam Pradeepkumar , Ramaiah Jinka Dasaratha 
Published: April 2021

Objective:
To determine the predictors of acceptance and willingness to pay (WTP) for the COVID-19 vaccine among the Indian public and to provide insights for future demand forecasts and pricing considerations.

Methods:
A nationwide, web-based, self-administered, cross-sectional survey was conducted from 5 to 20 October 2020. The health belief model (HBM) approach was used as a theoretical framework to assess the predictors of acceptance of and WTP for the COVID-19 vaccine.

Results:
Of 2 480 respondents, 2 451 completed the online survey, yielding a response rate of 98.8%. Participants who participated in the survey had diverse demographics in terms of their location, educational level, occupation type, and family income. Among 2 451 respondents, the majority (89.3%) intended to receive the COVID-19 vaccine. Respondents with high perceived benefits of COVID-19 vaccination, such as reduction in worry (OR 5.87; 95% CI 4.39-7.96) and sickness (OR 4.31; 95% CI 3.31-5.62), showed higher intention to receive the vaccine. However, respondents with a high perception of the side effects and barriers to vaccination (OR 0.36; 95% CI 0.25-0.54) and vaccine shortage (OR 0.58; 95% CI 0.41-0.81) showed lower intention to receive the vaccine. The majority (2 162, 88.21%) of respondents were willing to pay an amount of INR: 500-1 000 or USD: 6.81-13.62 for a dose of COVID-19 vaccine, with a median (Q1, Q3) of INR: 500 (500, 1 000) or USD: 6.81 (6.81, 13.62). The higher marginal WTP for the COVID-19 vaccine was influenced by advanced age, marital status, female sex, intermediate educational background, high family income, fair or poor perceived health status, and no affordable barriers.

Conclusions:
The majority of respondents intended to receive the COVID-19 vaccine. Healthcare interventions focusing on HBM constructs and demographic predictors associated with low intention to receive the vaccine can be effective in enhancing the coverage of the COVID-19 vaccine. The findings of this study provide guidance for the future price considerations of the COVID-19 vaccine.