bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma Levels of Keratinocyte Growth Factor Are Significantly Elevated for 5 Weeks After Minimally Invasive Colorectal Resection Which May Promote Cancer Recurrence and Metastasis
Authors: Shantha Kumara H. M. C. , Shah Abhinit , Miyagaki Hiromichi , Yan Xiaohong , Cekic Vesna , Hedjar Yanni , Whelan Richard L. 
Published: November 2021

Background: Human Keratinocyte Growth Factor (KGF) is an FGF family protein produced by mesenchymal cells. KGF promotes epithelial cell proliferation, plays a role in wound healing and may also support tumor growth. It is expressed by some colorectal cancers (CRC). Surgery's impact on KGF levels is unknown. This study's purpose was to assess plasma KGF levels before and after minimally invasive colorectal resection (MICR) for CRC.Aim: To determine plasma KGF levels before and after minimally invasive colorectal resection surgery for cancer pathology.Method: CRC MICR patients (pts) in an IRB approved data/plasma bank were studied. Pre-operative (pre-op) and post-operative (post-op) plasma samples were taken/stored. Late samples were bundled into 7 day blocks and considered as single time points. KGF levels (pg/ml) were measured via ELISA (mean ± SD). The Wilcoxon paired t-test was used for statistical analysis.Results: Eighty MICR CRC patients (colon 61%; rectal 39%; mean age 65.8 ± 13.3) were studied. The mean incision length was 8.37 ± 3.9 and mean LOS 6.5 ± 2.6 days. The cancer stage breakdown was; I (23), II (26), III (27), and IV (4). The median pre-op KGF level was 17.1 (95 %CI: 14.6–19.4; n = 80); significantly elevated (p &lt; 0.05) median levels (pg/ml) were noted on post-op day (POD) 1 (23.4 pg/ml; 95% CI: 21.4–25.9; n = 80), POD 3 (22.5 pg/ml; 95% CI: 20.7–25.9; n = 76), POD 7–13 (21.8 pg/ml; 95% CI: 17.7–25.4; n = 50), POD 14–20 (20.1 pg/ml; 95% CI: 17.1–23.9; n = 33), POD 21–27 (19.6 pg/ml; 95% CI: 15.2–24.9; n = 15) and on POD 28–34 (16.7 pg/ml; 95% CI: 14.0–25.8; n = 12).Conclusion: Plasma KGF levels were significantly elevated for 5 weeks after MICR for CRC. The etiology of these changes is unclear, surgical trauma related acute inflammatory response and wound healing process may play a role. These changes, may stimulate angiogenesis in residual tumor deposits after surgery.
THE EFFICIENCY OF RAISING DAIRY HEIFERS IN DIFFERENT TECHNOLOGIES
Authors: СИВКИН Н.В. , САЛУНБЕК П.Ж. , СТРЕКОЗОВ Н.И. 
Published: November 2021

Изучена эффективность выращивания телок молочных пород при различных технологиях. В качестве объекта исследований выступали 14 племенных хозяйств Центрального Федерального округа, разводящих высококровную по голштинам черно-пеструю и голштинскую породы крупного рогатого скота при использовании разных способов содержания и технологических схем выращивания телок до 6-месячного возраста. Содержание молодняка молочного периода на открытом воздухе, относительно помещений, способствует увеличению его сохранности до 12 мес. на 5,2%, а также более высокой энергии прироста и соответственно живой массы как в первый и шестой (на 11,8 кг и 38,1 кг, или 26,6% и 26,0%, Р≤0,01—0,001), так и десятый и двенадцатый месяцы жизни (на 46,1 кг и 52,3 кг, или 19,5% и 18,6%; Р≤0,05). В онтогенезе условия содержания и кормления телят раннего возраста оказывают наиболее существенное влияние на формирование продуктивных качеств скота. Так, в первые 2 мес жизни телки, когда основными кормами являлись цельное молоко и концентраты, коэффициент корреляции между среднесуточным приростом и надоем молока был наиболее высоким, достигая значений: r=0,34—0,42; с содержанием жира и белка на порядок ниже — r=0,19—0,22 и r=0,11—0,13 соответственно. В последующих возрастных периодах выращивания телок, с 4- до 10—12-месячного возраста корреляционная зависимость между этими признаками снижалась до минимальных значений.
Studies have been carried out to evaluate the efficiency of raising dairy heifer breeding using various technologies. The object of research were 14 breeding farms of the Central Federal District, breeding high-blooded Black-and-White and Holstein cattle breeds using different methods of housing and technological schemes for raising heifers up to 6 months of age. Housing young calves outdoors compared to building increases their survival rate up to 12 months by 5.2% and increased energy gain and live weight respectively in both the first and sixth months (by 11.8 kg and 38.1 kg, or 26.6% and 26.0%; P≤0.01-0.001) and the tenth and twelfth months (by 46.1 kg and 52.3 kg, or 19.5% and 18.6%; P≤0.05). During ontogeny, the conditions of housing and feeding of young calves have the most significant influence on the formation of productive qualities of livestock. Thus, in the first 2 months of the heifer's life, when the basic fodder was whole milk and concentrates, the correlation coefficient between an average daily gain in body weight and milk production was the highest, reaching the values: r=0.34-—0.42; with fat and protein content an order of magnitude lower - r=0.19-—0.22 and r=0.11—0.13, respectively. During the following age periods of heifer rearing, from 4 to 10—12 months of age, the correlation relationship between these traits decreased to minimum value.
DIFFERENCES OF APOLIPOPROTEIN A1 AND APOLIPOPROTEIN B LEVELS IN TYPE 2 DIABETES MELLITUS (T2DM) PATIENTS WITH DIABETIC RETINOPATHY AND WITHOUT DIABETIC RETINOPATHY
Authors: Hanifah Shabrina , Agni Angela Nurini , Mahayana Indra Tri , Suhardjo Suhardjo , Triyono Teguh 
Published: November 2021

Introduction Apolipoprotein A1 are antiatherogenic in blood serum and have an anti-inflammatory while Apolipoprotein B describes a protein structure that is potentially atherogenic.. Meanwhile, the inflammatory process plays a role in the diabetic retinopathy process. The aim of this study was to determine whether there were differences in the levels of apolipoprotein A1 and B in diabetic retinopathy patients and without diabetic retinopathy.
Methods: This study used a cross sectional design. The subjects of this study were type 2 diabetes mellitus patients with diabetic retinopathy and without diabetic retinopathy at Dr. Sardjito General Hospital from July to September 2020. Subjects consisted of 32 patients in the group with diabetic retinopathy and 31 patients without diabetic retinopathy. The levels of apolipoprotein A1 and apolipoprotein B were analyzed using independent T test. The factors affecting apolipoprotein A1 and apolipoprotein B were analyzed using multiple regression tests.
Result: There were no significant differences (p> 0.05) in age, gender, duration of diabetes, HDL, triglycerides, HbA1c, BMI, physical activity, and smoking history. The mean apolipoprotein A1 level in the diabetic retinopathy group was 1.46 ± 0.177 mg / dL higher than the non-diabetic retinopathy group, namely 1.44 ± 0.27 mg / dL (p = 0.699). The mean level of apolipoprotein B in the diabetic retinopathy group was 1.26 ± 0.289 mg / dl higher than the non-diabetic retinopathy group 1.01 ± 0.26 mg / dL (p = 0.001). The mean LDL levels were 162.5 ± 48.38 mmol / L in the diabetic retinopathy group and 127 ± 38.45 mmol / L in the group without diabetic retinopathy (p = 0.012).
Conclusion: Apolipoprotein B levels were found to be higher in the group with diabetic retinopathy than in the group without diabetic retinopathy and there was a significant difference between the two assumed due to an atherogenic process in the diabetic retinopathy group. Further research is needed to assess the causal relationship between elevated levels of Apo B and the incidence of diabetic retinopathy by calculating the ratio of apolipoprotein B to apolipoprotein A1.
Keywords: Apolipoprotein A1, Apolipoprotein B, Diabetic Retinopathy
PENERAPAN IOT (INTERNET OF THINGS) PADA PEMANTAUAN KESEHATAN KANDANG HEWAN JENIS LANDAK MINI BERBASIS ARDUINO DENGAN MENGGUNAKAN METODE LOGIKA FUZZY
Authors: Muzaky Mohammad Rizal , Pranoto Yosep Agus , Vendyansyah Nurlaily 
Published: November 2021

Hobi merawat binatang bagi sebagian orang dari usia muda sampai orang dewasa memiliki minat tersendiri, salah satunya memelihara binatang berjenis landak mini atau mempunyai bahasa latin hedgehog yang termasuk kedalam keluarga erinaceinae. Mengontrol suhu dan kelembaban kandang landak mini sangat penting bagi para pemelihara hewan tersebut apalagi ketika pemilik sedang tidak dirumah, landak mini dapat dipelihara dalam kotak kayu atau aquarium akrilik sebagai tempat pemeliharaan sehingga tidak memakan tempat yang lebih besar.
Dengan permasalahan latar belakang tersebut, penelitian mengembangkan sistem monitoring hewan jenis landak mini berbasis internet of things(IOT) agar pemilik dapat melakukan pemantauan kandang saat sedang tidak dirumah dan memberikan informasi secara langsung melalui internet, pada sistem ini terdapat beberapa sensor, modul dan aktuator ke dalam pembuatan sistem monitoring kandang hewan jenis landak mini berbasis Arduino seperti sensor DHT11, Motor Servo, sensor WaterLevel dan sensor Load Cell, Waterpump, Motor servo, lcd Display i2c,Hx711, L298N, Kipas dan Esp8266 yang digunakan untuk memonitoring kandang, sensor DHT11 digunakan untuk mendeteksi suhu dan kelembaban pada kandang, sensor Water Level digunakan untuk mendeteksi air minum pada kandang.
Dari hasil perhitungan, diketahui pengujian alat menggunakan sensor dht11 memiliki nilai keakuratan sebesar ± 93.82 % dengan rata presentase error sebesar 6,28%, sensor load cell memiliki nilai rata presentase error sebesar 3,08% sedangkan tingkat error pada sensor waterlevel sebesar 0,18%, kipas dapat menyala dengan kecepatan yang telah dihasilkan menggunakan basis aturan fuzzy mamdani, ketika suhu dan kelembaban kandang mencapai kondisi keanggotaan dingin, dan normal maka kipas akan berputar sedang, jika suhu dan kelembaban kandang mencapai panas dan lembab maka kipas akan menyala dengan cepat.
SISTEM MONITORING SUHU DAN KELEMBAPAN RUANGAN PASIEN ISOLASI COVID-19 BERBASIS IOT
Authors: Arfan Ravy Wahyu Pratama Mochamad , Agus Pranoto Yosep , Orisa Mira 
Published: November 2021

Situasi pandemi COVID-19 menjadi pembelajaran bagi Indonesia khususnya di bidang kesehatan. Problematika di bidang kesehatan semakin terlihat jelas di era pandemi COVID-19 ini. Kondisi saat ini tentunya menjadi kekhawatiran bagi seluruh masyarakat terkait dengan upaya pengendalian dan penanggulangan Pandemi COVID-19 ini di Indonesia, termasuk juga di kalangan medis dan tenaga kesehatan lainnya. Suhu tubuh normal berkisar antar 36,5⁰C - 37,5⁰C dan bila melebihi 38,5⁰C maka ada indikasi terinfeksi covid-19 yang kemudian akan diarahkan untuk isolasi baik mandiri atau di tempat yang telah disediakan.
Tujuan adanya ruang isolasi adalah untuk mengendalikan penyebaran penyakit menular yang bisa mewabah. Ruang isolasi adalah ruangan khusus, orang-orang yang bisa masuk ke ruangan ini juga sangat terbatas. Mengingat di ruang isolasi tidak bisa sembarangan keluar masuk, untuk itu dikembangkanlah sistem monitoring yang mampu memantau beberapa parameter yang dibutuhkan agar ruangan tersebut memenuhi standar operasional prosedur. Salah satunya adalah pengelolaan tata udara yang harus dijaga yaitu suhu ruangan dan kelembapan ruangan. Udara dalam ruangan dan kontaminan dalam ruangan minimal 6x pertukaran udara perjam dengan suhu ruangan 24 - 26 C dan kelembaban relatif 40 - 60%. Berdasarkan permasalahan diatas penulis ingin menerapkan Fuzzy logic metode Mamdani pada sistem monitoring suhu dan kelembapan ruangan pasien isolasi Covid-19 berabsis IOT ( Internet of Things ). Hal ini tentunya sangat membantu berbagai pihak mulai perorangan, hingga lembaga kesehatan utamanya rumah sakit umum.
Dari pengujian metode Fuzzy Logic tersebut diambil 10 data yang dibandingkan nilainya dengan Matlab, dapat dihasilkan rata-rata error output PWM sebesar 0.1%. Bedasarkan pengujian metode black box yang dilakukan dapat diketahui tampilan sistem sesuai dengan tampilan yang diharapkan, dengan persentase kesesuaian 100%. Untuk pengujian fungsional dapat diketahui tampilan website dapat berfungsi dengan baik pada browser Opera, Chrome, dan juga Microsoft Edge.
Uji Efektivitas Mukolitik Ekstrak Umbi Bawang Dayak (Eleutherine bulbosa (Mill) Urb)
Authors: Rambe Robiatun , Rani Zulmai , Thomas Nur Ain 
Published: November 2021

Dayak Onions are a typical Borneo plant that have been used by generations of Dayaks as herbal medicine. Empirically, tubers can be used as cough medicines. The purpose of this study was to determine the mucolytic effect of Dayak onion tuber extract by in vitro and the concentration range which gaves an equivalent effect with the effect of 0.1% acetylcysteine. This study conducted extraction using maceration. The test solution was made with a concentration of 0.5%, 1%, and 1.5% mixed with a mucus-phosphate buffer pH 7 20:80. The test solution was incubated for 30 minutes at 37oC. Further, positive control used was 0.1% acetylcysteine drug and the negative control was mucus solution without extract. Viscosity values obtained were analyzed using the One-way Anova statistical test with a confidence level of 99% (α 0.01). Based on the results, it was revealed that the extract of Dayak tuber with a concentration of 0.5%, 1%, and 1.5% showed a significant difference and a concentration of 0.5%. Mucolytic effectiveness was better than positive controls (acetylcysteine).
Colovesical fistula from infected urachal cyst
Authors: Forneiro Pérez R , Zurita Saavedra MS , Ramos Sanfiel J , Gutiérrez Sainz J , Mirón Pozo B 
Published: November 2021

Resumen

Introducción. Las anomalías uracales son raras tras el nacimiento presentándose la gran mayoría en niños menores de dos años (0,063% de los adultos).

Caso clínico. Varón de 27 años con un quiste uracal infectado sintomático que ha provocado además una fístula colovesical.

Discusión. Debido a su baja prevalencia y a la variabilidad de presentación clínica, supone un reto diagnóstico. El tratamiento consiste en una resección quirúrgica dada la posibilidad de malignización.
Supernova-driven Mechanism of Cusp-core Transformation: an Appraisal
Authors: Burger Jan D. , Zavala Jesús 
Published: November 2021

Abstract
We present and test an effective model for N-body simulations that aims at mimicking the impact of supernova (SN) feedback on the dark matter (DM) distribution of isolated halos hosting dwarf galaxies. Although the model is physically decoupled from the cosmological history of both the DM halo and the dwarf galaxy, it allows us to study the impact of different macroscopic parameters such as galaxy concentration, feedback energy, and energy injection time in the process of SN-driven core formation in a physically clear way. Using our effective model in a suite of N-body simulations of an isolated halo with different SN feedback parameters, we find that whether or not a DM core forms is determined by the total amount of SN feedback energy that is transferred to the DM particles. At a fixed injected energy, transfer of energy to the DM is more efficient the faster the energy is injected and the more compact the galaxy is, leading to an increased size of the formed DM core as a result. Analyzing the orbital evolution of kinematic tracers, we demonstrate that a core forms through SN feedback only if the energy injection is impulsive relative to the dynamical timescale of particles in the inner halo. However, there is no fundamental link between the total amount of injected energy and the injection rate. Consequently, the presence of signatures of impulsive changes of the gravitational potential is not a sufficient condition for dwarf-sized halos to have cored density profiles.
Stringent Tests of Gravity with Highly Relativistic Binary Pulsars in the Era of LISA and SKA
Authors: Miao Xueli , Xu Heng , Shao Lijing , Liu Chang , Ma Bo-Qiang 
Published: November 2021

Abstract
At present, 19 double neutron star (DNS) systems are detected by radio timing and two merging DNS systems are detected by kilohertz gravitational waves. Because of selection effects, none of them has an orbital period P

b
in the range of a few tens of minutes. In this paper we consider a multimessenger strategy proposed by Kyutoku et al., jointly using the Laser Interferometer Space Antenna and the Square Kilometre Array to detect and study Galactic pulsar-neutron star (PSR-NS) systems with P

b
∼ 10–100 minutes. We assume that we will detect PSR-NS systems by this strategy. We use standard pulsar-timing software to simulate times of arrival of pulse signals from these binary pulsars. We obtain the precision of timing parameters of short-orbital-period PSR-NS systems with orbital period P

b
∈ (8, 120) minutes. We use the simulated uncertainty of the orbital decay,

P

̇

b

, to predict future tests for a variety of alternative theories of gravity. We show quantitatively that highly relativistic PSR-NS systems will significantly improve the constraint on parameters of specific gravity theories in the strong field regime. We also investigate the orbital periastron advance caused by the Lense−Thirring effect in a PSR-NS system with P

b
= 8 minutes, and show that the Lense−Thirring effect will be detectable to a good precision.
S’accorder, vouloir dire et être reconnu·e au cours d’un entretien
Authors: Beldame Yann , Silvestri Laura 
Published: November 2021

Dans cet article nous analysons les interactions verbales survenues lors d’entretiens de recherche que nous avons réalisés avec des jeunes de 16 à 25 ans porteur·euse·s d’une trisomie 21 dans le cadre d’une enquête sur le devenir adulte des jeunes ayant des anomalies chromosomiques. Nous analyserons la manière dont les attentes et les représentations des enquêté·e·s, de leurs parents et des chercheur·e·s sur les personnes catégorisées « déficientes intellectuelles » ont pu contribuer à la constitution des normes d’interaction verbale et participer de la co-construction de situations de handicap. Nous nous arrêterons en particulier sur deux questions : celle de la compréhension mutuelle entre les chercheur·e·s et les enquêté·e·s, et celle des conditions de possibilité de l’expression de la parole des jeunes porteur·euse·s de trisomie 21. Cette dernière question permettra de s’interroger sur la possibilité de « vouloir dire » ce qui se dit lors d’un entretien de recherche, ainsi que sur les conditions de reconnaissabilité des personnes interviewées.
Chrysin ameliorates STZ-induced diabetes in rats
Authors: Salama Abeer , Asaad Gihan F. , Shaheen Aya 
Published: November 2021

Background and purpose:Growing evidence advocates that upregulation of toll-like receptor 4 (TLR4) has been suggested as a causative influence in the development and complications of diabetes mellitus. We aimed to study the antidiabetic activity of chrysin against streptozotocin (STZ)-induced diabetesviadown-regulation of TLR4/nuclear factor (NF-κβ)/heat shock protein 70 (HSP70) pathway as well as modulation of clusters of differentiation 4 (CD4+) in rats.Experimental approach:Fifty rats were divided into five groups (n = 10). Group I, normal rats received a single intraperitoneal injection of buffer citrate; group II, STZ-induced diabetic rats; groups III-V, diabetic rats received glimepiride (0.5 mg/kg; p.o.) or chrysin (40 and 80 mg/kg; p.o.) respectively, for 10 days. Serum samples were extracted to determine nitric oxide (NO), malondialdehyde (MDA), and reduced glutathione (GSH), insulin, CD4+, TLR4, and NF-κβ. Pancreatic tissue samples were extracted to determine glucose transporter 2 (GLUT2). Part of the pancreas was kept in formalin for pathological studies.Findings/Results:An elevation in blood glucose, NO, and MDA serum levels and a reduction of pancreatic GLUT2 content, insulin, and GSH serum levels were observed in diabetic rats. STZ injection, also, showed an increase in serum TLR4, NF-κβ, and HSP70 levels and a reduction in serum CD4+ levels with pancreatic cells necrosis. These biochemical and histological changes were reversed in glimepiride and chrysin groups.Conclusion and implications:The present study proved that chrysin has a potent anti-diabetic effect through the elevation of insulin and GLUT2 levels, the reduction of oxidative stress, and the inflammatory pathways TLR4/NF-κβ/HSP70 with the regulation of CD4+.
Oxypeucedanin and isoimperatorin extracted from Prangos ferulacea (L.) Lindl protect PC12 pheochromocytoma cells from oxidative stress and apoptosis induced by doxorubicin
Authors: Jalilian Fereshteh , Moieni-Arya Maryam , Hosseinzadeh Leila , Shokoohinia Yalda 
Published: November 2021

Background and purpose:
Doxorubicin (DOX) as a chemotherapeutic agent has been widely used in the treatment of various types of cancer. However, DOX exerts a toxic effect on normal tissues such as the brain. Furanocoumarins reduce the risk of cardiovascular and brain diseases because of their antioxidant activities. This study has been designed, for the first time, to evaluate the effect of known furanocoumarins oxypeucedanin and isoimperatorin extracted from Prangos ferulacea (L.) Lindl on oxidative stress and apoptosis induced by DOX toward pheochromocytoma cell line (PC12).

Experimental approach:
NMR and MASS spectrometers were used to characterize the isolated compounds. The protective effects of isolated compounds on DOX-induced cytotoxicity in PC12 cells were examined by MTT assay. PC12 cells were pretreated with oxypeucedanin and isoimperatorin for 2 and 21 h, respectively, subsequently exposure to DOX at IC50 concentration. Then, mitochondrial membrane potential (MMP), Bax and Bcl2 mRNA expressions, caspase-3 activation, and the generation of intracellular reactive oxygen species (ROS) were measured after 24 h.

Findings/Results:
Pretreatment with oxypeucedanin and isoimperatorin significantly decreased DOX-induced apoptosis through reduction of caspase-3 activity and ROS generation and an increase in MMP. In addition, our finding showed pretreatment with these compounds leads to regulation of Bcl-2.

Conclusion and implications:
Taken together our observation indicated that oxypeucedanin and isoimperatorin have a protective effect against apoptosis induced by DOX in PC12 cells by inhibition of ROS production.
Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
Authors: Motavallian Azadeh , Zamani Ehsan , Bouzari Saba , Rezaeyan Farzam , Karimian Paridokht , Evazalipour Mehdi 
Published: November 2021

Background and purpose:
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease characterized by the inflammation of the intestine. The available medicinal treatments for IBD are not efficacious enough since they exert various adverse effects. Therefore, the search for new therapeutic agents should be continued. The present study aimed to assess the anti-inflammatory effects of pregabalin on acetic acid-induced colitis in rats.

Experimental approach:
Using 2 mL of 3% acetic acid solution, colitis was intra-rectally induced in rats. Animals were randomly divided into 6 groups including the normal group, colitis control group, pregabalin treatment groups (30, 50, and 100 mg/kg; i.p., respectively), and dexamethasone treatment group (1 mg/kg; i.p.). Macroscopic, microscopic, and biochemical (myeloperoxidase, tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta) examinations were used to evaluate the efficacy of pregabalin in the inflamed colon.

Findings/Results:
All the applied doses of pregabalin significantly decreased the severity of macroscopic and microscopic colonic damages including ulcer severity, ulcer area, percentage of necrosis, and total colitis index compared to the colitis control group. These results were confirmed by the reduced colonic concentration of tumor necrosis factor-alpha, interleukin-6, interleukin-1 beta, and myeloperoxidase activity.

Conclusion and implications:
Results of this study indicated that pregabalin administration has beneficial effects upon the treatment of experimental colitis, which might be partly due to its anti-inflammatory properties.