bluuebunny/crossref_metadata_2025_split huggingface dataset:
Movement patterns of a Critically Endangered elasmobranch (Dipturus intermedius) in a Marine Protected Area
Authors: Lavender Edward , Aleynik Dmitry , Dodd Jane , Illian Janine , James Mark , Wright Peter J. , Smout Sophie , Thorburn James 
Published: December 2021

Abstract

Marine Protected Areas (MPAs) are widely used in marine management, but for mobile species understanding the spatio‐temporal scale of management measures that is required to deliver conservation benefits depends on a detailed knowledge of species’ movements that is often lacking. This is especially the case for species of skate (Rajidae) for which relatively few movement studies have been conducted.
In Scotland, the Loch Sunart to the Sound of Jura MPA covering 741 km2 has been designated for the conservation of the Critically Endangered flapper skate (Dipturus intermedius), but fine‐scale movements within this area remain poorly understood.
A passive acoustic telemetry study which coupled acoustic tagging of 42 individuals and a static array of 58 receivers was conducted from March 2016 to June 2017. Using acoustic detection time series, angler capture–recapture data and depth time series from archival tags, fine‐scale movements of individuals were investigated.
Overall, 33 of the 42 tagged individuals were detected. Residency, site fidelity and transiency were documented. Residency around receivers, lasting from 3 to more than 12 months, was documented in 16 acoustically detected individuals (48%) and all life‐history categories, but was most noticeable among females. Acoustic detections were associated with depth, salinity and season, but there was no evidence that individuals formed close‐knit groups in the areas in which they were detected.
Taken together with historical occurrence records of flapper skate, the prevalence and scale of residency documented here suggest that the MPA is sufficiently large to benefit a notable percentage (38 [24–52]%) of skate found in the study area over monthly and seasonal timescales. This result strengthens the case for the use of MPAs to support the conservation of flapper skate and other skate species that display similar movement patterns in areas of high local abundance.
Effects of nonnutritional sugars on lipid and carbohydrate content, physiological uptake, and excretion in Drosophila suzukii
Authors: Price Briana E. , Yoon June‐Sun , Choi Man‐Yeon , Lee Jana C. 
Published: December 2021

AbstractThe nonnutritive sugar, erythritol, has the potential to be a human‐safe management tool for the small fruits and cherry pest, Drosophila suzukii, or spotted‐wing drosophila. Feeding on erythritol decreases fly survival and oviposition by starving and creating an osmotic imbalance in the body. Recently, we demonstrated that erythritol combined with another nonnutritive sugar, sucralose, was fed upon more than erythritol alone and hastens D. suzukii mortality. This suggests that sucralose is a suitable nonnutritive phagostimulant alternative to sucrose. Although promising, the nutritional and physiological impacts of sucralose on D. suzukii are unknown. In this study, we investigated whether sucralose is metabolized or excreted by D. suzukii when fed various erythritol, sucrose, and sucralose formulations. We found that sucralose cannot be metabolized or converted into any nutritional substitutes or storage carbohydrates in D. suzukii. Instead, sucralose molecules were largely accumulated in the hemolymph and slowly excreted from the body, creating a significant osmotic imbalance in D. suzukii. To excrete unused sugars, flies will use their own body fluids to restore homeostasis, resulting in losing a substantial amount of body weight and becoming desiccated in the process. In summary, ingesting sucralose leads to starvation and hyperosmotic pressure in the body, causing a decrease in fitness. With confirmation of sucralose being non‐metabolizable and phagostimulative to D. suzukii, the erythritol+sucralose formulation is a promising insecticide for growers to use.
The neurocognitive profiles of justice involved people with foetal alcohol spectrum disorder: A systematic review
Authors: Khalifa Najat , Magee Taylor , Shirazi Shayan , Salman Shamir , Yang Cheng‐Chang , Mela Mansfield 
Published: December 2021

AbstractFoetal alcohol spectrum disorder (FASD) is highly prevalent in criminal justice settings. Despite increased awareness of the neurocognitive deficits among justice‐involved individuals with FASD, no systematic evaluation of the literature in the field has been conducted to date. We aimed to conduct a systematic review of the literature on the neurocognitive profiles of justice‐involved individuals with FASD, by searching five key electronic databases, dissertations database, and Google scholar, up to January 2021. The findings indicate that when contrasted with comparison groups, justice‐involved individuals with FASD display significant impairment in a greater number of neurocognitive domains including intellectual capacity, executive function, language, academic achievements, motor skills, and adaptive living skills. The relatively small number of the studies included in the review, along with the confounding effects of comorbidities among study participants, precludes drawing firm conclusions about the true extent and implications of neurocognitive deficits in this population. To advance the field further, there is an urgent need to conduct robust studies involving larger samples of justice‐involved individuals with FASD and suitable comparison groups. Advancing knowledge in the field can have important implications for understanding of the antecedents of offending behaviour in this population, and informing strategies for early identification and intervention.
Exploring secondary teachers' perspectives on implementing competency‐based education
Authors: Rogers Audrey P. 
Published: December 2021

AbstractBackgroundCompetency‐based education (CBE) has been implemented to varying degrees in the last several decades. New Hampshire has led the way in policy changes to promote its adoption. However, there has been a tension between the goals of the initiative and how teachers’ beliefs inform implementation.AimsThe purpose of this study was to take an in‐depth examination of NH middle and high school teachers’ beliefs around CBE and its impact on their classroom practices and students.MethodsThis study utilized a sequential explanatory mixed methods approach through survey data and follow‐up interviews and observations in three NH districts. The Concerns‐Based Adoption Model (CBAM) conceptual framework served as a lens to analyze data.ResultsThe three districts revealed varying levels of implementation mitigated in part by teachers’ beliefs. Participants in the district with more advanced CBE implementation described the largest perceived impact of transformed pedagogical practices and an ability to persist with or without administrative support. Some participants noted an increase in students’ access to the curriculum and a decrease in students’ anxiety and feelings of being judged.DiscussionFindings suggested that contextual factors informed participants’ beliefs and subsequent practices. Districts with administrative support revealed more widespread impact on teachers and students. Structural supports promoting implementation also supported teachers’ integration of CBE principles.ConclusionDistrict leaders need to attend to teachers’ beliefs to offer differentiated professional development and build on CBE elements already in place. Further study in how CBE principles may reduce student anxiety is timely and needed.
METTL3 is a key regulator of milk synthesis in mammary epithelial cells
Authors: Wang Lulu , Qi Hao , Li Dong , Liu Lijie , Chen Dongying , Gao Xuejun 
Published: December 2021

AbstractThe enzyme m6A methyltransferase‐like 3 (METTL3) catalyzes N6‐methyladenosine (m6A) modification in eukaryotic messenger RNAs (mRNAs). However, the physiological function and molecular mechanism of METTL3 in mammalian cells have not been fully understood. Here we showed that METTL3 was highly expressed in mouse mammary gland of the lactation period. METTL3 was located in the nucleus of bovine mammary epithelial cells (MECs), and methionine (Met) and β‐estrodial (E2) upregulated METTL3 protein level. METTL3 knockdown decreased milk protein and fat synthesis, whereas its overexpression had the opposite effects. METTL3 overexpression stimulated mRNA expression and protein phosphorylation of the mechanistic target of rapamycin (mTOR) and mRNA and protein expression of sterol regulatory element binding protein 1 (SREBP1), whereas METTL3 knockdown blocked the stimulatory effects of Met and E2 on these processes. Furthermore, METTL3 overexpression led to increased mRNA m6A methylation of mTOR and SREBP1, whereas METTL3 knockdown suppressed the stimulatory effects of Met and E2 on these processes. The interaction between METTL3 and glycyl‐tRNA synthetase (GlyRS) was confirmed by Co‐immunoprecipitation and fluorescence resonance energy transfer approaches, and colocalization observation further showed that Met and E2 treatment increased this interaction. GlyRS knockdown abolished METTL3 protein levels upregulated by Met and E2, and METTL3 knockdown markedly decreased the effects of GlyRS overexpression on mTOR expression and phosphorylation and SREBP1 expression. In summary, we demonstrate that METTL3 is a key positive regulator of Met and E2‐stimulated and GlyRS‐mediated mTOR and SREBP1 signaling pathways and milk protein and fat synthesis in mammary epithelial cells.
CDK5 inhibition improves glucose uptake in insulin‐resistant neuronal cells via ERK1/2 pathway
Authors: Manglani Kapil , Dey Chinmoy S. 
Published: December 2021

AbstractRole of CDK5 and its inhibition in various neuronal processes and functions are well established. However, role of CDK5 and its inhibition in neuronal insulin—signaling and—resistance is not yet explored. In the present study, we investigated the effect of CDK5 inhibition in neuronal insulin signaling, specifically insulin‐stimulated glucose uptake. CDK5 expression in neuro‐2a cells was increased under insulin‐resistant state, developed by chronic treatment of insulin, confirming the crucial role of CDK5 in insulin resistance in neuronal cells. However, whether increased expression of CDK5 in hyperinsulinemia‐mediated insulin‐resistant conditions is a cause or a consequence, is still an unanswered question. We showed that CDK5 inhibition did not affect basal insulin signaling; however, insulin‐stimulated glucose uptake enhanced in insulin‐resistant cells. Moreover, CDK5 inhibition could improve glucose uptake, the ultimate outcome of insulin signaling, in insulin‐resistant neuro‐2a cells. We first time showed that CDK5 inhibition by roscovitine could ameliorate insulin resistance and increase glucose uptake in neuronal cells via ERK1/2 pathway. Our study provides intriguing insights about the effect of CDK5 inhibition on neuronal insulin resistance and opens up a new paradigm to develop new therapeutic strategies for neuronal insulin resistance and associated pathophysiological conditions.
Five‐year follow‐up report: Box lesion radiofrequency ablation procedure for atrial fibrillation under video‐assisted thoracoscope
Authors: Ji Yupeng , He Li , Cheng Zeyi , Shi Jun , Liu Lulu , Guo Yingqiang 
Published: December 2021

AbstractWe report the initial 5‐year follow‐up of a novel mini‐invasive procedure for epicardial ablation for the treatment of atrial fibrillation. The initial 5‐year survival rate is acceptable and comparable with that of hybrid ablation. And this shared procedure has the advantages of shorter operation time and less surgical trauma.
Novel compound heterozygous mutations in the CYP4F22 gene in a patient with autosomal recessive congenital ichthyosis
Authors: Tang Haiyan , Shi Xiaoliu , Zhang Guiying 
Published: December 2021

AbstractAutosomal recessive congenital ichthyosis (ARCI) is a rare form of keratinization disorder of the skin, which can be caused by mutations in 14 ARCI genes. We present a rare case of ARCI that carried a novel null mutation and a novel splice site mutation in the CYP4F22 gene.
Sinonasal immunoglobin G4—related disease: case report and review
Authors: Wilson Caleb P. , Brownlee Benjamin P. , El Rassi Edward T. , McKinney Kibwei A. 
Published: December 2021

AbstractImmunoglobin G4—related disease (IgG4‐RD) is a chronic fibro‐inflammatory condition that presents as a single or multiple tumefactive lesions affecting virtually any organ system. Here we report a case of recurrent sinonasal IgG4‐RD and review the literature of this evolving entity.
Clinical course involving thrombocytosis and thrombocytopenia in a patient with bladder cancer treated with gemcitabine and cisplatin
Authors: Watanabe Ayako , Momo Kenji , Tanaka Katsumi , Nagata Takuya , Kuchira Remi , Morita Masashi , Sasaki Tadanori 
Published: December 2021

AbstractGemcitabine induce thrombocytopenia and thrombocytosis as toxicity. In this report, we show detailed time‐course for platelet fluctuation. Our case emphasis attention to monitor see‐saw‐like toxicity on platelet count.
Perceval sutureless aortic valve replacement after ascending aortic replacement
Authors: Yajima Shin , Satoh Ayaka , Sekiya Naosumi , Yamazaki Sachiko , Uemura Hisashi , Tanaka Hiroe , Yamamura Mitsuhiro , Sakaguchi Taichi 
Published: December 2021

AbstractIn patients with a narrow sinotubular junction, small sinus of Valsalva, or extensibility loss in the aortic root, aortic valve replacement (AVR) with a standard valve is challenging due to limited surgical field. Detailed preoperative measurements of the aortic root render performing AVR using the Perceval valve easy.
Lemierre’s syndrome caused by Fusobacterium necrophorum complicated with multiple brain abscesses—A case report, literature review, and suggested management
Authors: Kjellberg Anders , Bjerin Olof , Franzén‐Röhl Elisabeth , Bartek Jiri , Lindholm Peter 
Published: December 2021

AbstractWe present an unusual case of Lemierre´s syndrome complicated by multiple brain abscesses, a literature review and suggested management. A young man with multiple brain abscesses deteriorated despite two weeks of directed antibiotics. A multidisciplinary approach was successful. Hyperbaric oxygen treatment (HBOT) should be considered in refractory or severe cases.
Normoglycemic diabetic ketoacidosis in a type 2 diabetes patient on dapagliflozin: A case report
Authors: Matli Venkata Vinod Kumar , Fariduddin Maria M. , Asafo‐Agyei Kwabena Oppong , Bansal Nidhi 
Published: December 2021

AbstractA 48‐year‐old male patient with Type 2 diabetes mellitus(T2D), on insulin replacement therapy, glipizide, and dapagliflozin presented with generalized weakness with weight loss of 40 pounds in 6 months ever since he was started on dapagliflozin. He was hemodynamically stable on arrival with a finger stick glucose of 121 gm%. Physical examination was unremarkable except for dry mucus membranes. His laboratory results on arrival are shown in Table 1. His serum osmolar gap was within the normal range. He was treated insulin drip per DKA protocol and gap was closed, the patient was clinically and biochemically back to baseline, and he was discharged home. Delayed diagnosis of normoglycemic diabetic ketoacidosis (DKA) in adults with diabetes treated with multiple antidiabetic drugs (eg, sodium‐glucose cotransporter‐2 [SGLT‐2] inhibitors) can potentially increase morbidity and mortality. Patient education in terms of symptoms and signs, physician awareness of early recognition of ketoacidosis in the setting of paradoxically normal or near‐normal blood glucose levels in these patients is the primary focus of this case study. This is paradoxical DKA because theoretically patient is not meeting one of the criteria for DKA which include triad of hyperglycemia, Ketoacidosis with widened anion gap, Ketonemia. This is a short case report of presumed SGLT‐2 inhibitor euglycemic diabetic ketoacidosis. The main teaching point is recognition and early diagnosis of this issue when multiple diabetic medications are present with the absence of hyperglycemia. This is, by current definition, not DKA because theoretically, the patient does not meet one of the criteria for DKA as the patient was apparently not hyperglycemic, albeit with, ketoacidosis and widened anion gap. (ketonemia)
Acute lower limb ischemia in an ICU admitted patient diagnosed with the COVID‐19: A case report
Authors: Sadeghi Armin , Moselmi Mohammadreza 
Published: December 2021

AbstractThromboembolic events have been reported in the hospitalized patient since the beginning of the COVID‐19 pandemics. ICU‐admitted patients demonstrated a significantly higher risk of developing VTE. Although evidence of arterial thrombosis was less common in ICU‐admitted patients, consequences were typically more severe, including limb loss and death. This study reports another ICU‐admitted patient with lower extremity arterial thrombosis diagnosed with COVID‐19.
A successful pediatric case of vaginal foreign body detection on transabdominal ultrasonography
Authors: Nishiyama Kazutaka , Horikawa Shogo , Ono Yusuke 
Published: December 2021

AbstractVaginal foreign bodies usually present with bleeding and foul‐smelling discharge. It is often difficult to detect and identify vaginal foreign bodies in pediatric cases without any symptoms. Therefore, detection of vaginal foreign bodies using noninvasive methods, like transabdominal ultrasonography, is important in pediatric patients.
Confined placental mosaicism of trisomy 6 detected through genome‐wide NIPT was associated with placental abruption
Authors: Nishiyama Miyuki , Wada Seiji , Hasegawa Fuyuki , Uehara Yohji , Ozaki Mamoru , Hata Kenichiro , Ito Yushi , Sago Haruhiko 
Published: December 2021

AbstractConfined placental mosaicism (CPM) leads to discordant noninvasive prenatal testing (NIPT) results. We describe a very rare case of CPM of trisomy 6 detected through genome‐wide NIPT. This case was associated with placental abruption, which might suggest an association between certain types of CPM detected by NIPT and pregnancy complications.
Spontaneous pneumomediastinum mimicking acute pericarditis
Authors: Chaudhary Haseeb , Yousaf Zohaib , Nasir Usama , Waheed Tayyab , Syed Khezar 
Published: December 2021

AbstractST elevations on electrocardiogram (ECG) have a broad differential diagnosis that can vary from benign to more ominous pathologies. These include early repolarization, coronary vasospasm, acute pericarditis, ST‐elevation myocardial infarction, ventricular aneurysms, and dissecting aneurysm of the aorta reaching the pericardium. ST‐segment changes may also provide a clue to the presence of spontaneous pneumomediastinum (SPM). These ECG changes are seldom reported in literature. We describe two SPM cases with concomitant pneumopericardium that closely mimicked acute pericarditis with a deceptive clinical spectrum.
A rare and distinct bilateral ovarian tumor: Carcinosarcoma
Authors: Limaiem Faten , Halouani Ahmed , Saffar Khalil , Bouraoui Saâdia 
Published: December 2021

AbstractCarcinosarcomas are aggressive biphasic neoplasms composed of high‐grade, malignant, epithelial, and mesenchymal elements. They usually occur in the uterus and rarely involve the ovaries. Only 10% of them are bilateral. Their diagnosis relies on histological examination coupled with immunohistochemistry.
Inguinal hernia detected using radiography
Authors: Takashima Yoshito , Suda Tsuyoshi , Soga Shingo 
Published: December 2021

AbstractThere are various clinical presentations of inguinal hernia. Computed tomography is a well‐known tool to help diagnose inguinal hernia; however, radiographs are rarely reported to be useful in this aspect. We present a rare case wherein radiographs helped in the diagnosis of inguinal hernia.
Secondary hemophagocytic lymphohistiocytosis due to nivolumab/ipilimumab in a renal cell cancer patient—A case report
Authors: Masood Adeel , Wahab Ahsan , Clifford Tanya , Weaver Eric J. , Ehsan Hamid , El Ayass Walid 
Published: December 2021

AbstractSecondary immune‐related hemophagocytic lymphohistiocytosis is a rare but life‐threatening complication of immune checkpoint inhibitors. HLH‐2004 and HLH‐1994 guidelines originally developed for primary HLH are the only available guidelines. It has proven to have a good prognosis if diagnosed promptly with discontinuation of immunotherapy and treated with corticosteroid monotherapy.
Leukocyte chemotactic factor 2–related amyloidosis presenting with severe jaundice and hepatic encephalopathy
Authors: Almasri Hussam , Razok Almurtada , Badi Ahmed , Almohannadi Muneera , Lutf Abdo , Petkar Mahir , Elzouki Abdelnaser 
Published: December 2021

AbstractAmyloidosis is a well‐known disease with various types and subtypes. One of the most recently identified types is leukocyte chemotactic factor 2 amyloidosis (LECT 2), which was found to be common in certain ethnic backgrounds. It is suggested that the diagnosis of this type is vital to prevent any therapy‐related complications when it is erroneously diagnosed as AL amyloidosis. The clinical presentation is usually slowly progressive kidney disease and mild hepatic impairment. We report a case of LECT2 amyloidosis, which presented with severe painless cholestasis and hepatic encephalopathy alongside progressive kidney disease.
Integrated Water Treatment System for Peat Water Treatment
Authors: Khayan Khayan , Sutomo Adi Heru , Rasyid Ashari , Puspita Widyana Lakshmi , Hariyadi Didik , Anwar Taufik , Wardoyo Slamet , Sahknan Raja , Aziz Alkausyari 
Published: December 2021

AbstractThe supply of clean water is a major problem in both developed and developing countries. The abundant amount of peat water can be a potential source of clean water in areas with peatlands. Peat water treatment can be conducted effectively and efficiently by integrating various existing methods, such as aeration, sedimentation, and filtration using shell sand and activated carbon. The results show that the parameters of color, turbidity, Ferrum (Fe), microbiological parameters, and pH of peat water can be conditioned according to clean water standards. The average peat watercolor parameter before processing is 866.7 PtCo, 10.96 NTU turbidity, 2.48 mg L–1Fe, Fe, 4.30 pH, and coliform (microbial) peat water at 1068 CFU and after passing the color combination treatment to 28.83 PtCo, turbidity 2.19 NTU, Fe 0.22 mg L–1, and coliform 20 CFU and pH 6.83. Integrated peat water treatment is the most effective at the filtration and adsorption stages.
Projection‐based model reduction for the immersed boundary method
Authors: Luo Yushuang , Li Xiantao , Hao Wenrui 
Published: December 2021

AbstractFluid–structure interactions are central to many biomolecular processes, and they impose a great challenge for computational and modeling methods. In this paper, we consider the immersed boundary method (IBM) for biofluid systems, and to alleviate the computational cost, we apply reduced‐order techniques to eliminate the degrees of freedom associated with the large number of fluid variables. We show how reduced models can be derived using Petrov–Galerkin projection and subspaces that maintain the incompressibility condition. More importantly, the reduced‐order model (ROM) is shown to preserve the Lyapunov stability. We also address the practical issue of computing coefficient matrices in the ROM using an interpolation technique. The efficiency and robustness of the proposed formulation are examined with test examples from various applications.