bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of a gastrobronchial fistula and lung abscess caused by leakage from the staple line of a gastric tube after esophagectomy for esophageal cancer
Authors: Nishimura Tohru , Fuse Chisakou , Akita Masayuki , Takase Nobuhisa , Maeda Eri , Abe Koichiro , Kozuki Akihito , Yokoyama Kunio , Tanaka Tomohiro , Kishi Shinji , Sakamoto Toshihiko , Sakai Tetsuya , Kaneda Kunihiko 
Published: April 2021

Abstract
Background
Gastrobronchial fistulas are rare, but life-threatening, complications of esophagectomy. They are caused by anastomotic leakage and mainly occur around anastomotic sites. In the present paper, we report a rare case of leakage from the staple line of a gastric tube after esophagectomy for esophageal cancer, which was successfully treated using an intercostal muscle flap and lung resection.

Case presentation
A 61-year-old male underwent subtotal esophagectomy with regional lymphadenectomy for esophageal cancer. The sutures along the staple line of the gastric tube failed 11 days after surgery, and a pulmonary abscess was also found on imaging. The abscess did not heal after conservative treatment; therefore, right lower lobectomy, gastrobronchial fistula resection, primary closure, and patching of the leaking portion of the gastric tube with an intercostal muscle flap were performed 9 months after the first operation. The patient’s postoperative course was uneventful, and he was discharged on the 354th day.

Conclusions
We experienced a case involving a gastrobronchial fistula caused by leakage from the staple line of a gastric tube and successfully treated it by performing right lower lobectomy and patching the leak with an intercostal muscle flap.
Effect of hydrophilic or hydrophobic interactions on the self-assembly behavior and micro-morphology of a collagen mimetic peptide
Authors: Luo Xiaomin , Huo Qianqian , Liu Xinhua , Zheng Chi , Liu Ying 
Published: April 2021

Abstract
Peptide self-assembles with bionic properties have been widely utilized for bioactive drugs and biomedical materials. Collagen mimetic peptide (CMP) gains more attention due to its unique advantages in biosecurity and function. Unfortunately, the self-assembly mechanism of CMP, particularly the effect of intermolecular forces on its self-assembly behavior and morphology, is still unrecognized. Herein, the hydrophilic glycidol (GCD) and hydrophobic Y-glycidyl ether oxypropyl trimethoxysilane (GLH) were grafted onto the side chains of CMP through the ring-opening reaction (GCD/CMP, GLH/CMP). Subsequently, the effects of hydrophilic and hydrophobic interactions on the self-assembly behavior and morphology of CMP were further studied. The results substantiated that the GCD/CMP and GLH/CMP self-assembly followed “nucleation-growth” mechanism, and the supererogatory hydrophilic and hydrophobic groups prolonged the nucleation and growth time of CMP self-assembly. Noted that the hydrophilic interaction had stronger driving effects than hydrophobic interaction on the self-assembly of CMP. The GCD/CMP and GLH/CMP self-assembles exhibited fibrous 3D network and microsphere morphology, respectively. Furthermore, the GLH/CMP self-assembles had better resistance to degradation. Consequently, the microtopography and degradation properties of CMP self-assembles could be controlled by the hydrophilic and hydrophobic interactions between CMP, which would further provide a way for subsequent purposeful design of biomedical materials.

Graphical abstract
COVID-19 clinico-radiological mismatch: a proposal for a novel combined morphologic/volumetric CT severity score with blinded validation
Authors: Samir Ahmed , Elnekeidy Abdelaziz , Gharraf Heba Said , Baess Ayman Ibrahim , El-Diasty Tarek , Altarawy Dina 
Published: April 2021

Abstract
Background
Some COVID-19 patients with similar quantitative CT measurements had variable clinical presentation and outcome. The absence of reasonable clinical explanations, such as pre-existing comorbidities or vascular complications, adds to the confusion. The authors believed that neglecting the impact of certain severe morphologic features could be an alternative radiological explanation. This study aims to optimize the initial CT staging of COVID-19 and propose a new combined morphologic/volumetric CT severity index (CTSI) to solve this clinico-radiological mismatch.

Results
This multi-center study included two major steps. The first step of the study entailed a standardized combined morphologic/volumetric CT severity analyses to propose a new optimized CTSI. This was conducted retrospectively during the period from June till September 2020. It included 379 acutely symptomatic COVID-19 patients. They were clinically classified according to their oxygen saturation and respiratory therapeutic requirements into three groups: group A (mild 298/79%), group B (borderline severity 57/15%), and group C (severe/critical 24/6%). The morphologic and volumetric assessment of their HRCT was analyzed according to severity, by two consultant radiologists in consensus. A new 25 point-CTSI has been created, combining eight morphological CT patterns [M1:M8; 8 points] and four grades of volumetric scores [S1:S4; 17 points]. The addition of the M5 pattern (air bubble sign), M6 pattern (early fibrosis and architectural distortion), or M7 pattern (crazy-paving) proved to increase the clinical severity. The second step of the study entailed a standardized blinded/independent validation analysis for the proposed CTSI. This was prospectively conducted on other 132 patients during October 2020 and independently performed by other two consultant radiologists. Validation results reached 80.2% sensitivity, 91.8% specificity, AUROC-curve = 0.8356, and 90.9% accuracy.

Conclusion
A new optimized CTSI with accepted validation is proposed for initial staging of COVID-19 patients, using combined morphologic/volumetric assessment instead of the quantitative assessment alone. It could solve the clinico-radiological mismatch among patients with similar quantitative CT results and variable clinical presentation during the absence of pre-existing comorbidities or vascular complications.
Consensus on the Treatment and Follow-Up for the Nonmetastatic Castration-Resistant Prostate Cancer: A Report From the First Prostate Cancer Consensus Conference for Developing Countries
Authors: Pereira Felipe Moraes Toledo , Silva Adriano Gonçalves e , Dettino Aldo Lourenço Abbade , Cardoso Ana Paula Garcia , Sasse Andre Deeke , Kann Ariel Galapo , Dzik Carlos , Herchenhorn Daniel , Jardim Denis Leonardo Fontes , Lopera Diego , Ayadi Mouna , Salman Pamela , Kopp Ray Antonio Manneh , De Carvalho Ricardo Saraiva , Cavallero Sandro Roberto De Araujo , Aguiar Sergio , Souza Vinicius Carrera , Uson Junior Pedro Luiz Serrano , Soares Andrey 
Published: April 2021

PURPOSE To present a summary of the recommendations for the treatment and follow-up for the biochemical recurrence of castration-resistant prostate cancer (PCa) as acquired through a questionnaire administered at the Prostate Cancer Consensus Conference for Developing Countries. METHODS A total of 27 questions were identified as relating to this topic. Responses from the clinician were tallied and are presented in percentage format. Topics included the use of imaging in staging, treatment recommendations across different patient scenarios of life expectancy and prostate-specific antigen (PSA) doubling time, and follow-up for nonmetastatic castration-resistant PCa. RESULTS A consensus agreed that in optimal conditions, positron emission tomography-computed tomography with prostate-specific membrane antigen would be used although in limited resource situations the combined use of CT of the abdomen and pelvic (or pelvic MRI), a bone scan, and a CT of the thorax or chest x-ray was recommended. In cases when PSA levels double in < 10 months, more than 90% of clinicians agreed on the use of apalutamide or enzalutamide, regardless of life expectancy. With a doubling time of more than 10 months, > 54% of experts recommended no treatment independent of life expectancy. More than half of the experts, regardless of resources, recommended follow-up with a physical examination and PSA levels every 3-6 months and imaging only in the case of symptoms. CONCLUSION The voting results and recommendations presented in this document can be used by physicians to support management for biochemical recurrence of castration-resistant PCa in areas of limited resources. Individual clinical decision making should be supported by available data.
Standards-Based Physical Education in Schools: The Role of State Laws
Authors: Sprow Kyle , Perna Frank M. , Leider Julien , Turner Lindsey , Piekarz-Porter Elizabeth M. , Michael Shannon L. , Brener Nancy , Chriqui Jamie F. 
Published: April 2021

ABSTRACT
This study aimed to examine the association of state physical education (PE) laws (https://class.cancer.gov) with school policies addressing motor skill development, physical activity participation, and health-enhancing physical fitness (https://www.cdc.gov/healthyyouth/data/shpps/data.htm). National school-level data on PE standards were obtained from the 2014 School Health Policies and Practices Study of U.S. schools for analytical samples of 408–410 schools in 43 states. These data were linked to the Classification of Laws Associated with School Students data, which reflect the strength of state PE curriculum laws and the associated state PE curriculum standards. Logistic regressions and generalized linear models with a complementary log–log link examined associations between state law and school-level standards. Compared with having no state law, weak law (odds ratio [OR] = 5.07, 95% confidence interval [CI] = 1.02–25.27) or strong law (OR = 2.96, 95% CI = 1.04–8.37) was associated with higher odds of school PE standards addressing motor skill development, whereas only strong state law was associated with higher prevalence of addressing achievement and maintenance of physical fitness (coefficient = 0.63, 95% CI = 0.12, 1.14). State laws were not associated with addressing physical activity participation. Schools were more likely to address motor skills and physical fitness development when states had strong PE laws.
The role of preoperative diffusion tensor imaging in predicting and improving functional outcome in pediatric patients undergoing epilepsy surgery: a systematic review
Authors: Leon-Rojas Jose , Cornell Isabel , Rojas-Garcia Antonio , D’Arco Felice , Panovska-Griffiths Jasmina , Cross Helen , Bisdas Sotirios 
Published: April 2021

Objective: Diffusion tensor imaging (DTI) is a useful neuroimaging technique for surgical planning in adult patients. However, no systematic review has been conducted to determine its utility for pre-operative analysis and planning of Pediatric Epilepsy surgery. We sought to determine the benefit of pre-operative DTI in predicting and improving neurological functional outcome after epilepsy surgery in children with intractable epilepsy. Methods: A systematic review of articles in English using PubMed, EMBASE and Scopus databases, from inception to January 10, 2020 was conducted. All studies that used DTI as either predictor or direct influencer of functional neurological outcome (motor, sensory, language and/or visual) in pediatric epilepsy surgical candidates were included. Data extraction was performed by two blinded reviewers. Risk of bias of each study was determined using the QUADAS 2 Scoring System. Results: 13 studies were included (6 case reports/series, 5 retrospective cohorts, and 2 prospective cohorts) with a total of 229 patients. Seven studies reported motor outcome; three reported motor outcome prediction with a sensitivity and specificity ranging from 80 to 85.7 and 69.6 to 100%, respectively; four studies reported visual outcome. In general, the use of DTI was associated with a high degree of favorable neurological outcomes after epilepsy surgery. Conclusion: Multiple studies show that DTI helps to create a tailored plan that results in improved functional outcome. However, more studies are required in order to fully assess its utility in pediatric patients. This is a desirable field of study because DTI offers a non-invasive technique more suitable for children. Advances in knowledge: This systematic review analyses, exclusively, studies of pediatric patients with drug-resistant epilepsy and provides an update of the evidence regarding the role of DTI, as part of the pre-operative armamentarium, in improving post-surgical neurological sequels and its potential for outcome prediction.
Different therapeutic effects between diabetic and non-diabetic adipose stem cells in diabetic wound healing
Authors: Gong Jia-Hong , Dong Jiao-Yun , Xie Ting , Zhao Qingnan , Lu Shu-Liang 
Published: April 2021

Objective:This study aimed to investigate how adipose tissue-derived stem cells (ASCs) from diabetic and from non-diabetic rats affect wound healing in different microenvironments.Method:The two types of ASC-rich cells were distinguished by characteristic surface antigen detection. The ASC-rich cells were transplanted into the wounds of diabetic and non-diabetic rats. Wound healing rates were compared and the healing process in the wound margin sections was used to determine how ASC-rich cells affect wound healing in different microenvironments.Results:ASC density was decreased in diabetic rats. The generation time of ASC-rich cells from diabetic rats (d-ASC-rich cells) was longer than that of ASC-rich cells from non-diabetic rats. The number of pre-apoptotic cells in the third generation (passage 3) of d-ASC-rich cells was higher than that among the ASC-rich cells from non-diabetic rats. CD31 and CD34 expression was higher in d-ASC-rich cells than in ASC-rich cells from non-diabetic rats, whereas CD44 and CD105 expression was lower than that in ASC-rich cells from non-diabetic rats. Transplantation of ASC-rich cells from non-diabetic rats promoted wound healing in both non-diabetic and diabetic rats. In contrast, d-ASC-rich cells and enriched nuclear cells only promoted wound healing in non-diabetic rats. ASC-rich cell transplantation promoted greater tissue regeneration than d-ASC-rich cell transplantation.Conclusion:ASC-rich cells promoted wound healing in diabetic and non-diabetic rats. ASC density was lower in the adipose tissue of diabetic rats compared with non-diabetic rats. d-ASC-rich cells did not promote wound healing in diabetic rats, suggesting that caution is warranted regarding the clinical use of diabetic adipose stem cell transplantation for the treatment of diabetic wounds.
Field Reliability Estimation of Agricultural Tractors Based on Warranty Data
Authors: Zhao Zhilin , Cheng Fang 
Published: April 2021

HighlightsA LightGBM regression model for predicting tractor usage rates was established based on warranty data and considering agricultural tractors’ usage context (region and season) and was then interpreted using SHAP.The field reliability of tractors was estimated based on the usage of failed and unfailed tractors, after unfailed tractors’ usage was imputed using the LightGBM regression model.The proposed methodology was validated by predicting warranty claims using estimated reliability parameters.The proposed methodology was demonstrated using warranty data from a tractor manufacturing company in China.Abstract. Warranty data provide a valuable source of information for assessing the reliability of products in operation (called the field reliability). However, warranty data consist of failure information only. The unavailability of usage data for unfailed products makes it difficult to estimate the reliability of durable products such as agricultural tractors, for which usage is a greater concern than age for reliability analysis. Several studies have proposed methods to address this problem, but they did not include information on the usage context. This study proposes a methodology to estimate the field reliability of agricultural tractors from warranty data considering the tractors’ usage context. First, by taking features representing tractors’ usage context as the input, a usage rate regression model was established using a light gradient boosting machine (LightGBM). The usage of unfailed tractors was then generated. Finally, parametric estimates of the tractors’ reliability were determined based on the usage of failed and unfailed tractors. By interpreting the LightGBM model using SHapley Additive exPlanations (SHAP), it was found that tractors that were used more days in October and April had higher predicted usage rates. To validate the effectiveness of the proposed methodology, the estimated reliability parameters were used to predict the warranty claims of six types of tractors. The results showed that the proposed methodology performed the best in four cases and close to the best in two other cases when compared with two other baseline methods. The proposed methodology was demonstrated using warranty data from an agricultural tractor manufacturing company in China and can be applied to improve understanding of tractor reliability. Keywords: Field reliability, LightGBM, SHAP, Usage context, Warranty data.
Effect of parental smoking on their children’s urine cotinine level in Korea: A population-based study
Authors: Park Myung-Bae , Ranabhat Chhabi Lal 
Published: April 2021

Background
Children may be exposed to tobacco products in multiple ways if their parents smoke. The risks of exposure to secondhand smoke (SHS) are well known. This study aimed to investigate the association between parental smoking and the children’s cotinine level in relation to restricting home smoking, in Korea.

Methods
Using the Korea National Health and Nutrition Health Examination Survey data from 2014 to 2017, we analyzed urine cotinine data of parents and their non-smoking children (n = 1,403), in whose homes parents prohibited smoking. We performed linear regression analysis by adjusting age, sex, house type, and household income to determine if parent smoking was related to the urine cotinine concentration of their children. In addition, analysis of covariance and Tukey’s post-hoc tests were performed according to parent smoking pattern.

Finding
Children’s urine cotinine concentrations were positively associated with those of their parents. Children of smoking parents had a significantly higher urine cotinine concentration than that in the group where both parents are non-smokers (diff = 0.933, P < .0001); mothers-only smoker group (diff = 0.511, P = 0.042); and fathers-only smoker group (diff = 0.712, P < .0001). In the fathers-only smoker group, the urine cotinine concentration was significantly higher than that in the group where both parents were non-smoker (diff = 0.221, P < .0001), but not significantly different compared to the mothers-only smoker group (diff = - -0.201, P = 0.388). Children living in apartments were more likely to be exposed to smoking substances.

Conclusion
This study showed a correlation between parents’ and children’s urine cotinine concentrations, supporting the occurrence of home smoking exposure due to the parents’ smoking habit in Korea. Although avoiding indoor home smoking can decrease the children’s exposure to tobacco, there is a need to identify other ways of smoking exposure and ensure appropriate monitoring and enforcement of banning smoking in the home.
The effectiveness of two different exercise approaches in adolescent idiopathic scoliosis: A single-blind, randomized-controlled trial
Authors: Kocaman Hikmet , Bek Nilgün , Kaya Mehmet Hanifi , Büyükturan Buket , Yetiş Mehmet , Büyükturan Öznur 
Published: April 2021

Objectives
The purpose of this study was to compare the efficacy of two different types of exercise methods in patients with adolescent idiopathic scoliosis.

Methods
In total, 28 subjects with adolescent idiopathic scoliosis with a mild curve magnitude (10°–26°) were randomly divided into two groups: the Schroth group (n = 14) and the core group (n = 14). The patients in the Schroth group were treated with supervised Schroth exercises, and the patients in the core group were treated with supervised core stabilization exercises; both groups performed the exercises for three days per week for a total of 10 weeks, and both were given additional traditional exercises to perform. Assessment included Cobb angle (Radiography), trunk rotation (Adam’s test), cosmetic trunk deformity (Walter Reed Visual Assessment Scale), spinal mobility (Spinal Mouse), peripheral muscle strength (Biodex System 4-Pro), and quality of life (Scoliosis Research Society-22 questionnaire).

Results
It was found that patients in the Schroth group showed greater improvement in Cobb angles, thoracic trunk rotation angle, cosmetic trunk deformity, spinal mobility, and quality of life than those in the core group (p<0.05), except for in lumbar trunk rotation angle. Peripheral muscle strength improvement was greater in the core group than in the Schroth group (p<0.05).

Conclusion
Schroth exercises are more effective than core stabilization exercises in the correction of scoliosis and related problems in mild adolescent idiopathic scoliosis, and core stabilization exercises are more effective than Schroth exercises in the improvement of peripheral muscle strength.

Trial registration
NCT04421157
Influence of fibromucosa height and loading on the stress distribution of a total prosthesis: a finite element analysis
Authors: Paes Junior Tarcisio José de Arruda , Tribst João Paulo Mendes , Dal Piva Amanda Maria de Oliveira , Figueiredo Viviane Maria Gonçalves de , Borges Alexandre Luiz Souto , Inagati Cristiane Mayumi 
Published: April 2021

Purpose: To evaluate the effect of fibromucosa height on the stress distribution and displacement of mandibular total prostheses during posterior unilateral load, posterior bilateral load and anterior guidance using the finite element analysis (FEA). Material and methods: 3D virtual models were made to simulate the stress generated during different mandibular movements in a total prosthesis. The contacts were simulated according to the physiology, being considered perfectly bonded between cortical and medullar bones; and between cortical bone and mucosa. Non-linear frictional contact was used for the total prosthesis base and fibromucosa, allowing the prosthesis to slide over the tissue. The cortical bone base was fixed and the 100 N load was applied as unilateral load, posterior bilateral load and anterior guidance simulation. The required results were for maximum principal stress (MPa), microstrain (mm/mm) and total displacement (mm). The numerical results were converted into colorimetric maps and arranged according to corresponding scales. Results: The stress generated in all situations was directly proportional to the fibromucosa height. The maximum principal stress results demonstrated greater magnitude for anterior guidance, posterior unilateral and posterior bilateral, respectively. Only posterior unilateral load demonstrated an increase in bone microstrain, regardless of the fibromucosa height. Prosthesis displacement was lower under posterior bilateral loading. Conclusion: Posterior bilateral loading is indicated for total prosthesis because it allows lower prosthesis displacement, lower stress concentration at the base of the prosthesis and less bone microstrain.

Keywords
Finite element analysis; Occlusion; Total prosthesis.