bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
Authors: Harder Aster V.E. , Winsvold Bendik S. , Noordam Raymond , Vijfhuizen Lisanne S. , Børte Sigrid , Kogelman Lisette J.A. , de Boer Irene , Tronvik Erling , Rosendaal Frits R. , Willems van Dijk Ko , O'Connor Emer , Fourier Carmen , Thomas Laurent F. , Kristoffersen Espen S. ,   Cluster Headache Genetics Working Group, Fronczek Rolf , Pozo‐Rosich Patricia , Jensen Rigmor H. , Ferrari Michel D. , Hansen Thomas F. , Zwart John‐Anker , Terwindt Gisela M. , van den Maagdenberg Arn M.J.M 
Published: June 2021

ObjectiveIdentifying common genetic variants that confer genetic risk for cluster headache.MethodsWe conducted a case–control study in the Dutch Leiden University Cluster headache neuro‐Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord‐Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell‐derived RNA‐sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses.ResultsAn association was found with cluster headache for 4 independent loci (r2 < 0.1) with genomewide significance (p < 5 × 10−8), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33–1.72 near RP11‐815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37–1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26–1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54–0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene‐based mapping yielded ASZ1 as possible fifth locus. RNA‐sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients.InterpretationThis genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders. ANN NEUROL 2021;90:203–216
Decompressive Hemicraniectomy for Middle Cerebral Artery Stroke: Indications and Perioperative Care
Authors: Karasin Beth , Grzelak Monica , Rizzo Gina , Hardinge Tara , Eskuchen Lauren , Boyce Marissa , Watkinson Johanna 
Published: June 2021

ABSTRACTDecompressive hemicraniectomy (DHC) is a procedure performed in the setting of malignant cerebral edema after a large middle cerebral artery stroke. The decision to proceed with surgical decompression is one that must be made judiciously and rapidly. Although this can be a life‐saving surgery, it does not necessarily improve the patient’s quality of life. The neurosurgical team must thoroughly discuss the patient’s comorbidities, age, dominant versus nondominant hemispheric injury, and neurological expectations, and the procedure itself (ie, risks, benefits, expected postoperative course, goals of care) with the patient and his or her family before DHC. This article briefly reviews the anatomy of the brain and stroke presentation and provides an overview of DHC and the perioperative course. The article concludes with a case study of a patient with a medical history of hypertension and prediabetes who presents to the emergency department after a fall and undergoes an emergent DHC.
UV curable micro‐structured shape memory epoxy with tunable performance
Authors: Ren Hua , Xie Lulin , Xu Yang , Zhao Qian , Zheng Ning 
Published: June 2021

AbstractMicro‐structured shape memory polymer (SMP) surfaces are indispensable in various applications. Epoxy polymer emerged as an ideal candidate for SMP surfaces due to its low curing shrinkage and superior thermo‐mechanical properties. In this study, we develop a UV curable epoxy system with tunable glass transition temperature and superior shape memory performance. The glass transition temperatures can widely range from 49 to 164°C by simply tuning the ratio of two comonomers. All samples possess excellent shape fixity, shape recovery ratios, and cycling stability. The synergy of the moldable liquid epoxy precursors and the spatiotemporal UV light allows shape memory epoxy with both surface microstructures and complex macro‐geometries. We anticipate this UV curable epoxy will expand the scopes of surface shape memory applications.
Outcomes in patients with newly diagnosed TP53‐mutated acute myeloid leukemia with or without venetoclax‐based therapy
Authors: Venugopal Sangeetha , Shoukier Mahran , Konopleva Marina , Dinardo Courtney D. , Ravandi Farhad , Short Nicholas J. , Andreeff Michael , Borthakur Gautam , Daver Naval , Pemmaraju Naveen , Sasaki Koji , Montalban‐Bravo Guillermo , Marx Kayleigh R. , Pierce Sherry , Popat Uday R. , Shpall Elizabeth J. , Kanagal‐Shamanna Rashmi , Garcia‐Manero Guillermo , Kantarjian Hagop M. , Kadia Tapan M. 
Published: June 2021

BackgroundVenetoclax (VEN) in combination with a hypomethylating agent (HMA) has become the standard of care for patients aged >75 years and for those not eligible for intensive chemotherapy who have newly diagnosed acute myeloid leukemia (AML). The benefit of VEN‐based therapy in patients who have newly diagnosed AML with mutations in the TP53 gene (TP53mut) over standard therapy is undefined.MethodsIn this single‐institutional, retrospective analysis, the authors assessed the clinical outcomes of 238 patients with newly diagnosed TP53mut AML and compared the clinical characteristics, response to different therapies, and outcomes of those who received VEN‐based (n = 58) and non–VEN‐based (n = 180) regimens.ResultsPatients who received VEN‐based regimens were older (aged >65 years: 81% vs 65%; P = .02) and had higher response rates (complete remission, 43% vs 32%; P = .06) than those who received non–VEN‐based regimens. Compared with patients who received non–VEN‐based regimens, no difference in overall survival (median, 6.6 vs 5.7 months; P = .4) or relapse‐free survival (median, 4.7 vs 3.5 months; P = .43) was observed in those who received VEN‐based regimens, regardless of age or intensity of treatment.ConclusionsThe addition of VEN to standard treatment regimens did not improve outcomes in younger or older patients who had TP53mut AML. These data highlight the need for novel therapies beyond VEN to improve the outcome of patients with TP53mut AML.
Shared care for children with cancer in India through social and healthcare partnerships during the COVID‐19 pandemic
Authors: Mahajan Amita , Arora Ramandeep Singh , Sahi Puneet Kaur , Gomber Sunil , Radhakrishnan Nita , Bagchi Basab , Jain Prachi , Kumar Arvind , Singh Avinash , Gupta Haresh , Sharma Sonal , Ahamad Nasim , Bagai Poonam , Kumar Arvind 
Published: June 2021

AbstractBackgroundThe COVID pandemic posed a challenge for the tertiary centers to continue treatment. Some tertiary centers were designated as COVID‐only hospitals, making it difficult for existing childhood cancer patients to continue their treatment at those centres. The need for shared care in childhood cancer was perceived by Cankids and its partnering childhood cancer‐treating centers in North and East India.AimWe aim to show how Cankids upscaled its shared care model to ensure that COVID designated hospitals connected with other hospitals who have to continue to provide care to childhood cancer patients in the pandemic and thus ensured the continuation of treatment for these patients.Methods and resultThe need assessment of the beneficiaries was done in discussion with the hospital of origin and destination hospital. The need for shared care was also discussed with the families and consent was taken before shifting their children. Cankids with the help of advisors identified cases of high risk that need immediate attention, proactive regular monitoring, and help in care planning with the perspective and recommendation of the multiple providers. The shared care unit came forward with reasonable and discounted packages for treatment.There was a total of five hospitals requiring shared care, and 55 children were supported from April to November 2020. The median age was 8 years and their hospital of origin are in Bihar, Uttar Pradesh, West Bengal, and Delhi. The expenditure on the treatment of the 55 patients was INR 61 61 636 ($ 84 843), with a median of INR 41765 (IQR 19491–174 129) on each patient. Total 291 trips for the transport were arranged and all the patients combined stayed 174 days at Cankids accommodation facility.ConclusionThe shared care helped the patients access standard treatment and reduce the financial burden.
Exploring color attractiveness and its relevance to fashion
Authors: Kodžoman Duje , Hladnik Aleš , Pavko Čuden Alenka , Čok Vanja 
Published: June 2021

AbstractMany studies have been conducted on the phenomenon of color preference, with the aim of identifying the key color preferences. Most of the previous studies have been placing blue in the most preferred position and green‐yellow in the least preferred position. This study was conducted online and aims to showcase new color preference trends in the digital age. The colors selected for this study were based on the colors most frequently mentioned in previous color studies. Here, we show an evaluation using 14 Pantone colors as stimuli on the sample of (N = 146) participants based on pairwise adjectives (attractive‐unattractive). Principal component analysis and other multivariate statistics were used to examine participants' color attractiveness. In addition, gender and age were examined to determine if they had an impact on color attractiveness ratings. Results show that participants tend to prefer distinctive colors (black, pink, yellow), but there are slight differences in preferences that could be related to the influence of gender and age.
Parallel network component analysis technique for gene regulatory network inference
Authors: Elsayad Dina , Hamad Safwat , Shedeed Howida A. , Tolba Mohamed F. 
Published: June 2021

AbstractThe inference of gene regulatory network has a vital role in understanding the topological order of gene interactions, in addition to how genes are affected by the others genes. One of gene regulatory network techniques is Network Component analysis. The primary drawback of Network Component analysis technique is the intensive computation and time consummation. To avoid these drawbacks, parallel techniques are required. This work presents a parallel technique for gene regulatory network inference; referred as Improved Parallel Computation for Sparse Network Component Analysis (iPSparseNCA) algorithm. To improve the performance of network component analysis technique, iPSparseNCA implements a hybrid parallelism computational model that uses cannon's algorithm for the matrix operations. The performance of iPSparseNCA is measured using different genetic datasets. The computational results indicate that iPSparseNCA achieved high computational speedup, where the achieved speedup reached 1359.85 on 256 processing nodes. These computational results indicate that iPSparseNCA achieved super linear speedup, where, the achieved speedup exceeds the number of used processing nodes. Furthermore, iPSparseNCA has O (N2) time instead of O (M3N2) time for the sequential technique, where M is the number of genes in the dataset and N is the number of the samples.
Diverse values, philosophies and ideas beget innovation and resilience in ecology and for our world
Authors: Morrison Deb L. , Steltzer Heidi 
Published: June 2021

AbstractIntellectual diversity, which is often assessed through social diversity proxies, such as race, ethnicity, and gender, is essential to innovation in ecology. There are many diverse ways of knowing, valuing, and discerning alternatives within ecology and as it is applied to solve global‐change issues. However, science is a cultural activity, one that is affected by colonialism, racism, and White supremacy and, like other fields of science, the pursuit of ecological careers has historically been a space of limited opportunities for participation for Black, Indigenous, and People of Color (BIPOC)—narrowing the diverse ways of knowing, valuing, and engaging in ecological work. We seek to debunk the view that such limited participation is a result of BIPOC lacking interest in or proficiency in science, and instead offer that BIPOC communities are places of deep scientific understanding, sociocultural resilience, and cultural wealth. Scientists must broaden their consideration of the ecological sciences and work with BIPOC to establish community‐based scientific partnerships that will foster increased ecological career pathways for BIPOC youth.
Pitfall trap design affects the capture efficiency of harvestmen (Opiliones) and millipedes (Diplopoda)
Authors: Stašiov Slavomír , Čiliak Marek , Wiezik Michal , Svitok Marek , Wieziková Adela , Diviaková Andrea 
Published: June 2021

AbstractPitfall trapping is one of the standard methods used for the capture of ground‐active arthropod groups. Despite being frequently used, the standardization of this method is problematic due to the large range of combinations of the individual parameters of pitfall traps with varying efficacy under different environmental conditions. We evaluated the effects of the trap diameter, the fixing fluid, and their combination on the capture efficacy for harvestmen (Opiliones) and millipedes (Diplopoda). We used pitfall traps with three different diameters: 3 cm, 5 cm, and 12 cm, filled with three types of fixing fluids (saturated fluid of NaCl, 10:1 mixture of 70% ethanol and glycerol and 4% formaldehyde). Altogether, 90 traps representing nine combinations of trap diameters and fixing fluid were placed on a mown meadow in spring and autumn intervals for a total of 45 days. We sampled 1,488 individuals representing 11 harvestmen species and 881 individuals representing 11 millipede species. Large (d = 12 cm) and medium (5 cm) traps captured significantly more millipede species and individuals than the small‐sized traps (3 cm). The same effect was observed for harvestmen species richness, whereas the medium traps (d = 5 cm) captured the highest mean activity of harvestmen. By analyzing the differences in the body sizes of the studied arthropods in relation to the trap diameter and fluid, we found that larger traps, as well as traps filled with NaCl solution, captured larger harvestmen more frequently than the other trap types. Our results revealed that the combination of larger traps (d = 5 and 12 cm) and formaldehyde was most effective in the capture of both studied groups. However, the disadvantage of formaldehyde is its toxicity.
Natural history of the relict marsupial Monito del Monte at the most extreme altitudinal and latitudinal location
Authors: Mejías Carlos , Castro‐Pastene Carlos A. , Carrasco Héctor , Quintero‐Galvis Julian F. , Soto‐Gamboa Mauricio , Bozinovic Francisco , Nespolo Roberto F. 
Published: June 2021

AbstractUntil a few years ago, the “monito del monte” (Dromiciops gliroides) was considered the sole surviving species of Microbiotheria, the sister group of Australidelphia (Australian marsupials). However, the recent identification of a new species relegated to the northern range (Dromiciops bozinovici) and newly discovered populations of Dromiciops beyond the known limits for the geographic range demands for new studies in extreme locations. In this report, we describe the northernmost population of D. bozinovici at a high Andean location (Reserva Nacional Altos de Lircay [RNAL], which represents a record of Dromiciops distribution both in latitude [35° S] and in altitude [1696 m a.s.l.]). We live‐trapped individuals, performed behavioral observations, and extracted mtDNA (Cytb) for analyzing phylogenetic affinities. Together with confirming the phylogenetic position of RNAL within the D. bozinovici clade, interesting aspects of this isolated population arose, such as the sympatry with a didelphid marsupial (Thylamys elegans), and phylogenetic closeness with populations 300 km southward coastal. Our trapping effort yielded approximately 9.3 individuals/ha, which is relatively high compared with other small mammal populations, but typical for Dromiciops. Using in situ thermographic imaging during a night transect, we detected free‐ranging animals running vertically at ~3.6 km/h through the logs of mature trees (Nothofagus pumilio), which is fast compared with other small runners (e.g., cursorial rodents), and also compared with Dromiciops from other locations. We compared the critical time to escape, of RNAL individuals which resulted significantly higher than Dromiciops from Nahuelbuta and Valdivia, suggesting that animals from RNAL are more tolerant to human presence than other populations, which is probably due to the high level of isolation of this population. According to the IUCN the northernmost distribution of Dromiciops reaches Cauquenes, thus this report extends the distribution in 120 km to the North East. Interesting aspects, such as hibernation at freezing temperatures and the existence of a viable D. bozinovici population northward of RNAL, warrant further research on this interesting location.
Long‐term electro‐clinical profile of sudden cardiac arrest survivors
Authors: Shaker Hussam , Milan Anna , Alsallom Faisal , Newey Christopher , Hantus Stephen , Punia Vineet 
Published: June 2021

AbstractObjectiveRecent research has explored the use of continuous EEG (cEEG) monitoring for prognostication of spontaneous cardiac arrest (SCA). However, there is limited literature on the long‐term (post‐hospital discharge) electrographic findings among SCA survivors and their clinical correlates. Our study aims to fill this critical knowledge gap.MethodsWe retrospectively used our EEG database to identify adults (≥18 years) with SCA history who underwent an outpatient laboratory‐based EEG between 01/01/2011 and 12/31/2018. After electronic medical records (EMR) review, patients with epilepsy history and unclear/poorly documented SCA history were excluded. Outpatient EEGs were reviewed by authors. Acute EEG findings were extracted from the EEG database and EMR. In addition, we extracted data on acute and long‐term neuroimaging findings (CT/MRI), post‐SCA seizures, and anti‐seizure medications (ASM) status. Descriptive analysis and Fisher's exact test were performed.ResultsWe included 32 SCA survivors (50% women; mean age = 52.1 ± 13.6 years) in the study. During a median clinical follow‐up of 28.2 months, 3 patients suffered only clinical seizures, 3 only chronic post‐hypoxic myoclonus, and 5 had both [11 (34.4%) in total]. Interictal epileptiform discharges (IEDs) were noted in one‐third of the patients, which localized to vertex and frontocentral regions in all but one patient. Five (15.6%) of them did not suffer a clinical seizure despite the presence of EAs. Patients who developed epilepsy were significantly more likely to have abnormal neuroimaging findings [10/11 (90.9%)] during the follow‐up compared to the rest of the patients [OR = 25 (95% CI 2.6–>100, P = .002)]. Half of the study cohort was taking ASM at the last follow‐up.SignificanceOur small study reveals a signature location of IEDs in SCA survivors. Neuroimaging abnormalities seem to be a better indicator of epilepsy development, while EEG may reveal markers of potential epileptogenicity in the absence of clinical seizures. Future, larger studies are needed to confirm our findings.
Long‐term shifts in feedbacks among glacier surface change, melt generation and runoff, McMurdo Dry Valleys, Antarctica
Authors: Bergstrom Anna , Gooseff Michael , Fountain Andrew , Hoffman Matthew 
Published: June 2021

AbstractGlaciers of the McMurdo dry valleys (MDVs) Antarctica are the main source of streamflow in this polar desert. Because summer air temperatures hover near 0°C small changes in the energy balance strongly affect meltwater generation. Here we demonstrate that increased surface roughness, which alters the turbulent transfer of energy between the ice surface and atmosphere, yields a detectable increase in meltwater runoff. At low elevations on the glaciers, basin‐like topography became significantly rougher over 13 years between repeat lidar surveys, yielding greater melt. In contrast, the smoother ice at higher elevation exhibited no detectable change in roughness. We pose a conceptual model of the cycle of glacier surface change as a result of climate forcing whereby glacier surfaces transition from being dominated by sublimation to becoming increasingly melt‐dominated, which is reversible under prolonged cool periods. This research advances our understanding of warm season effects on polar glaciers.
Apalutamide‐associated skin rash in patients with prostate cancer: Histological evaluation by skin biopsy
Authors: Tohi Yoichiro , Kataoka Koki , Miyai Yumi , Kaku Yo , Dainichi Teruki , Haba Reiji , Tsunemori Hiroyuki , Sugimoto Mikio 
Published: June 2021

IntroductionApalutamide‐associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding.Case presentationCase 1: a 71‐year‐old man with metastatic castration‐sensitive prostate cancer developed a skin rash after 70 days of apalutamide treatment. Case 2: a 71‐year‐old man with non‐metastatic castration‐resistant prostate cancer developed a skin rash after 71 days of apalutamide treatment. In both cases, the skin rash presented as a slightly exudative erythema. The histology showed spongiosis of the epidermis and perivascular and interstitial infiltration of lymphocytes and eosinophils in the upper dermis without necrotic keratinocytes.ConclusionApalutamide‐induced skin rashes can involve an eczematous reaction clinically and histologically.
Cell–surface interactions on gold‐coated polydimethylsiloxane nanocomposite structures: Localized laser heating on cell viability
Authors: Danyuo Yiporo , Obayemi John David , Salifu Ali Azeko , Oyewole Oluwaseun Kehinde , Azeko ‪Salifu Tahiru , Ani Chukwuemeka Joseph , Dozie‐Nwachukwu Stella , Yirijor John , Abade‐Abugre Miriam , Odusanya Olushola Segun , McBagonluri Fred , Soboyejo Winston Oluwole 
Published: June 2021

AbstractThis article presents the results of cell–surface interactions on polydimethylsiloxane (PDMS)‐based substrates coated with nanoscale gold (Au) thin films. The surfaces of PDMS and PDMS–magnetite (MNP)‐based substrates were treated with UV‐ozone, prior to thermal vapor deposition (sputter‐coated) of thin films of titanium (Ti) onto the substrates to improve the adhesion of Au coatings. The thin layer of Ti was thermally evaporated to improve interfacial adhesion, which was enhanced by a 40‐nm thick film microwrinkled/buckled wavy layer of Au, that was coated to enhance cell–surface interactions and protein absorption. Cell–surface interactions were studied on the hybrid surfaces using a combination of optical and fluorescence microscopy. Consequently, cell proliferation and surface cytotoxicity (of the sputter‐coated PDMS surfaces) were elucidated by characterizing the metabolic activity in the presence of breast cancer and normal breast cells. The photothermal conversion efficiency associated with laser–materials interactions with the PDMS/PDMS–magnetite‐based composites was shown to have an optimum efficiency of ~31.8%. The implications of the results are discussed for potential applications of PDMS nanocomposites in implantable biomedical devices.