bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of Probiotic Properties of L. fermentum MT308789 and L.oris MT308790 Isolated from Mother Breast Milk
Authors: Shradhdha M Gondaliya  , Vimal M Ramani  
Published: January 2021

Mother milk is a complete food for the child. It contains vital nutrients and biomolecules required for the growth and development of a child. It mainly contains carbohydrates, proteins, fats and minerals. Recently, it was also found that it contains certain different microorganisms which play a vital role in the body. Most of the microorganism of milk belongs to the Lactobacilli family. Knowing the importance of Lactobacilli in health, certain food industries have focused on these microorganisms to be used as a health supplement nowadays called probiotics. Here in this study, Lactobacilli were isolated from mother breast milk and their probiotic characteristics were studied to determine their potential for probiotic. Strains were isolated using MRS medium and analyzed for their biochemical properties, pH resistance, bile salt tolerance, NaCl concentration and antimicrobial activity. Results of the study have shown that out of two strains, one strain was L. fermentum MT308789 and other was L oris MT308790. Both the species have shown good resistance to acidic pH and bile salt. They were also having good antimicrobial activity. Based on the study it was found that both strains have potential to be used as probiotic.
A Review on the Development of Spectroscopic Sensors for the Detection of Creatinine in Human Blood Serum
Authors: Krishanu Sarkar  
Published: January 2021

Creatinine measurement is the key parameter in detecting renal, muscular and thyroid dysfunction. The accurate detection of creatinine level may be informative regarding the functional processes of these systems and help in early detection of acute diseases.There are lots of techniques available for detecting creatinine in human blood serum, most of them are of mainly based on spectroscopic (spectrophotometry, colorimetry and fluorimetric). Other techniques are based on electrochemical, impedometrical, Ion Selective Field-Effect Transistor (ISFET) and chromatography techniques. Each method has its own advantages and few limitations(limitation would be better word) regarding selectivity, sensitivity, reproducibility, cost effective, point-of-care level detection etc. Few methods based on electrochemical techniques are recently promising in detecting creatinine at the point-of-care level with adequate sensitivity and selectivity. On the other hand some biosensors based on spectroscopic techniques are recognized as the most promising substitute in recent years. As creatinine levels in the blood serum offer better information about patient status, here in this review it is thoroughly discussed over other biological samples such as urine, saliva.
Social Deprivation and Incident Diabetes-Related Foot Disease in Patients With Type 2 Diabetes: A Population-Based Cohort Study
Authors: Riley Jenny , Antza Christina , Kempegowda Punith , Subramanian Anuradhaa , Chandan Joht Singh , Gokhale Krishna , Thomas Neil , Sainsbury Christopher , Tahrani Abd A. , Nirantharakumar Krishnarajah 
Published: January 2021

OBJECTIVE
To investigate the relationship between social deprivation and incident diabetes-related foot disease (DFD) in newly diagnosed patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
A population-based open retrospective cohort study using The Health Improvement Network (1 January 2005 to 31 December 2019) was conducted. Patients with type 2 diabetes free of DFD at baseline were stratified by Townsend deprivation index, and risk of developing DFD was calculated. DFD was defined as a composite of foot ulcer (FU), Charcot arthropathy, lower-limb amputation (LLA), peripheral neuropathy (PN), peripheral vascular disease (PVD), and gangrene.

RESULTS
A total of 176,359 patients were eligible (56% men; mean age 62.9 [SD 13.1] years). After excluding 26,094 patients with DFD before/within 15 months of type 2 diabetes diagnosis, DFD incidentally developed in 12.1% of the study population over 3.27 years (interquartile range 1.41–5.96). Patients in the most deprived Townsend quintile had increased risk of DFD compared with those in the least deprived (adjusted hazard ratio [aHR] 1.22; 95% CI 1.16–1.29) after adjusting for sex, age at type 2 diabetes diagnosis, ethnicity, smoking, BMI, HbA1c, cardiovascular disease, hypertension, retinopathy, estimated glomerular filtration rate, insulin, glucose/lipid-lowering medication, and baseline foot risk. Patients in the most deprived Townsend quintile had higher risk of PN (aHR 1.18; 95% CI 1.11–1.25), FU (aHR 1.44; 95% CI 1.17–1.77), PVD (aHR 1.40; 95% CI 1.28–1.53), LLA (aHR 1.75; 95% CI 1.08–2.83), and gangrene (aHR 8.49; 95% CI 1.01–71.58) compared with those in the least.

CONCLUSIONS
Social deprivation is an independent risk factor for the development of DFD, PN, FU, PVD, LLA, and gangrene in newly diagnosed patients with type 2 diabetes. Considering the high individual and economic burdens of DFD, strategies targeting patients in socially deprived areas are needed to reduce health inequalities.
ANALISIS PENGARUH ANOMALI IKLIM TERHADAP CURAH HUJAN DI PROVINSI BENGKULU
Authors: Ismail Muhammad Rizky , Zakaria Ahmad , Susilo Gatot Eko 
Published: January 2021

Provinsi Bengkulu adalah salah satu daerah di Indonesia yang terpengaruh anomali iklim diantaranya adalah bencana banjir dan kekeringan, sehingga diperlukan penelitian untuk mengetahui pengaruh anomali iklim terhadap curah hujan di provinsi Bengkulu. Tujuan dari penelitian ini adalah untuk mengetahui daerah yang dominan terpengaruh anomali iklim, Mengetahui perulangan anomali iklim dan kecendrungan pertumbuhan anomali iklim di provinsi Bengkulu. Metode yang digunakan dalam analisis ini adalah Metode Fast Fourier Transform dan Lomb Periodogram. Hasil dari analisis ini adalah periode frekuensi dominan adalah Perulangan 2,8035 tahun untuk FFT, sedangkan Lomb periodogram adalah 3,8 – 4,4 tahun. hasil analisis FFT bahwa nilai Amplitudo dari data BMKG adalah 1,2 mm2-3,4 mm2. Untuk data TRMM hasil amplitudo adalah 0,1 mm2 – 0,6 mm2. Dengan metode Lomb Periodogram didapatkan nilai amplitudo 2,5 mm2 – 25 mm2 dari data BMKG. Sedangkan untuk TRMM adalah 0,28 mm2- 0,37 mm2 Kesimpulan dari analisis ini adalah bahwa anomali iklim yang berpengaruh menurut hasil FFT adalah IODM dengan perulangan 2,8035 tahun. untuk hasil dari Lomb Periodogram yang berpengaruh adalah ENSO dengan perulangan 3,8 – 4,4 tahun. disimpulkan pula, daerah dominan terpengaruh anomali iklim menurut data BMKG adalah Kepahiyang, sedangkan untuk TRMM adalah fatmawati dan Pulau Baai. Untuk kecendrungan pertumbuhan Pengaruh anomali Iklim. Bahwa setiap stasiun kecuali fatmawati BMKG punya kecendrungan naik pengaruhnya.
READING DIGITAL TEXT AS A NEW LITERACY IN ELT: TEACHERS' PERCEPTION & PRACTICES
Authors: Laeli Anita Fatimatul , Setiawan Slamet , Anam Syafi'ul 
Published: January 2021

Technological developments in the 21st-century impacted teaching and learning English. one of the impacts of this technological development is reading activities and competencies, reading experienced a phase of change from printed text to digital text. The change from Printed text to digital text requires new literacies, such as locating information and synthesizing online information. This study aims to investigate teachers' perceptions of reading digital texts in ELT. About twenty-three ELT teachers, both in junior and senior high schools around East Java, were involved in this study. An online open questionnaire was distributed to portray ELT teachers' attitudes, knowledge, and practices in reading digital text. The study reveals that all teachers have a positive attitude toward the practice of reading digital text. However, most teachers have misconceptions about knowledge and practice in implementing reading digital text activities. Surprisingly, all teachers in this study claimed that they never received a particular workshop to read digital text activities for English class. Hopefully, this study's result could contribute to the ELT curriculum in responding to the need to facilitate the new literacy in (online) reading and teacher professional development to develop teachers' reading digital text competencies. However, teachers as facilitators in classroom learning activities must recognize new literacy in online reading (especially reading digital text) to help students achieve reading competence in today's digital-based information era.
TEKNIK WATERMARKING MENGGUNAKAN METODE LEAST SIGNIFICANT BIT PADA CITRA UNTUK PERLINDUNGAN HAK CIPTA MOTIF BATIK
Authors: WIDIYONO WIDIYONO , WIBOWO ARI PUTRA , DARMAWAN ARIEF SOMA 
Published: January 2021

Batik merupakan karya seni yang dijadikan kultur budaya asli Indonesia. Sehingga batik dikenal dunia sebagai ciri khas Indonesai, dengan banyak sekali motif yang beranekaragam. Keanekargaman motif batik merupakan khas dari masing-masing daerah se-Indonesia. Motif Batik Pekalongan memiliki khas keanekaragman warna, perpaduan motif alam, dan motif moderen. Pada era digital pemasaran batik melalui marketplace yang telah menjangkau dunia dengan tidak terbatas. Tetapi motif batik digital rawan untuk dimanipulasi sehingga diperlukan perlindungan hak cipta motif batik secara digital. Untuk itu pada penelitian ini dilakukan perancangan dan pengembangan aplikasi watermarking dengan menggunakan metode Least Signnificant Bit (LSB). Pembuatan aplikasi watermarking pada penelitian ini menggunakan bahasa pemrograman java dengan netbeans versi 7.4. Dari sistem aplikasi watermarking yang dirancang dilakukan pengujian, bahwa aplikasi ini dapat berfungsi dengan baik sebagai solusi untuk perlidungan hak cipta motif batik. Kata Kunci: Least Significant Bit, Motif Batik, Watermaking,
DESAIN 3D KEMASAN MINYAK WANGI APLIKASI CAD (COMPUTERED AIDED DESIGN) DENGAN METODE API (ANALYSIS PRODUCT INSPECTION)
Authors: MUCHID MOCHAMMAD 
Published: January 2021

Pembuatan produk yang sempurna tidak terlepas dari proses design yaitu 3D modeling & 2D Drawing. Penelitian ini bertujuan adalah membuat rancangan model 3D pada produk kemasan minyak wangi dengan aplikasi CAD, Menghitung hasil pengukuran tutup kemasan minyak wangi secara CPK (Penyimpangan) dan secara Average (rata-rata). Metode yang digunakan pada penelitian ini adalah pengambilan data keputusan menggunakan api (analysis product inspection). Hasil penelitian yang diperoleh adalah hasil pengukuran tutup kemasan minyak wangi secara CPK (penyimpangan) mendapatkan hasil 0.89, 0.08, -0.41 dan 0.40 diantara nol dan satu menandakan rata-rata proses terletak dalam batas spesifikasi tetapi bagian variasi terletak diluar spesifikasi. Hasil Pengukuran tutup kemasan minyak wangi Secara average, terdapat angka yang berwarna merah yang menandakan dimensi inspection keluar dari basic dimensions khususnya pada point nomer 3 sample 1 sampai 5 semuanya keluar dari batas toleransi . Kata Kunci : Model 3D, Aplikasi CAD, API
SISTEM DETEKSI INTRUSI DAN PREVENSI BERBASIS OPEN SOURCE
Authors: NUR HIDAYAT ANDI MUHAMMAD 
Published: January 2021

Dalam infrastruktur pembuat jaringan nirkabel menjadi dilirik oleh semua orang. Hal ini menimbulkan resiko yang dapat terjadi dikarenakan setiap pengguna yang mampu menangkap gelombang elektromagnetik yang ditransmisikan oleh Access Point. Pengguna disini bisa memanfaatkan celah yang terjadi pada jaringan Nirkabel. Celah yang dimaksud adalah serangan yang dilakukan oleh orang yang tidak bertanggung jawab, sehingga membuat pengguna lain kehilangan data, informasi penting dan sebagainya. Maka perlu adanya aplikasi yang dapat mendeteksi dan mencegah serangan yang dapat terjadi. Salah satu aplikasi yang cukup baik yaitu WAIDPS berbasis opensource sehingga dapat dikembangkan lebih lanjut oleh penggunanya. Pada penelitian kali ini, aplikasi WAIDPS digunakan untuk mendeteksi serangan yang terjadi, terlebih dahulu dibuat scenario untuk menguji aplikasi tersebut. Saat pengujian scenario serangan yang dilakukan mampu dideteksi oleh aplikasi WAIDPS dan aplikasi WAIDPS dapat berjalan pada komputer dengan resource memory yang cukup kecil. Kata Kunci: WAIDPS, Sistem Deteksi Intrusi, Open Source, Security;
Efficacy and safety of the metformin-mazindol anorectic combination in rat
Authors: Argüelles-Tello Federico , Roa-Coria José Eduardo , Zúñiga-Romero Ángel , Huerta-Cruz Juan Carlos , Quiñonez-Bastidas Geovanna Nalley , Flores-Murrieta Francisco Javier , Rocha-González Héctor Isaac , Reyes-García Juan Gerardo 
Published: January 2021

Abstract
The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED
40t) did not differ from the experimental effective dose 40 (ED
40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED
40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors.
Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity
Authors: Monton Chaowalit , Chuanchom Panupong , Popanit Puwadon , Settharaksa Sukanya , Pathompak Pathamaporn 
Published: January 2021

Abstract
The aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. Curcuma longa alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of C. longa and C. aromatica in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that C. longa alone exhibited the highest antioxidant activity.
The Engineers Case Centenary: SCOTUS and the Origins of Australia's Scabrous Constitutional Signature
Authors: Gussen Benjamen Franklen , Araghi Sahar 
Published: January 2021

Abstract
Since the Engineers Case decision in 1920, the role of the United States Constitution in interpreting the Australian Constitution has been diminished, leading to inefficiencies in High Court of Australia (HCA) dealing with constitutional issues. To explain this thesis, the article looks at the 7,657 cases decided by the HCA, from the first case in 1903, to the 31st of August 2020, the centenary of the Engineers Case. The analysis identifies outliers that have much higher complexity (in terms of word-length) than the other judgments. This complexity has one common denominator: comparative analysis with the United States Constitution. The article explains why this common denominator has resulted in such complexity, and concludes with possible research extensions on the roles of the Australian judiciary in embracing SCOTUS jurisprudence when interpreting the Australian Constitution.
Are new genome variants detected in SARS-CoV-2 expected considering population dynamics in viruses?
Authors: Ergoren Mahmut Cerkez , Tulay Pinar , Dundar Munis 
Published: January 2021

Abstract
The pandemic COVID-19 is caused by a highly transmissible severe acute respiratory coronavirus 2 (SARS-CoV-2) which showed the highest morbidity and mortality rates among the other coronavirus infections such as SARS-CoV and MERS-CoV. However, the numbers of infected cases as well as mortality rates are varying from population to population. Therefore, scientist has urged the SARS-CoV-2 genome and host genetic factors investigations. Recently, new SARS-CoV-2 variants has been detected and though to affect the diseases transmission from human to human. In this mini-review, we aimed to explained detected SARS-CoV-2 variants that thought to influence the COVID-19 severity and transmission using the literature.
Vitamin D3 as possible diagnostic marker of Eating Disorders
Authors: Bella Vanessa La , Gizzi Giulia , Albi Elisabetta , Codini Michela , Marucci Simonetta , Ragione Laura Dalla , Beccari Tommaso , Ceccarini Maria Rachele 
Published: January 2021

Abstract

Purpose
Eating Disorders (EDs) refer to a group of psychiatric conditions in which disorderly food intake results in impaired psychological functioning or physical health. Nowadays, these disorders represent an increasing problem in modern society. There are no universally validated clinical parameters to confirm, disprove or simply help to identify EDs except for diagnostic criteria on psychiatric basis. The aim of this study was the assessment of Vitamin D3 level in patients with EDs to understand if it might be a valid clinical biochemistry parameter useful as prognostic marker.

Methods
The sample consists of 28 female patients, who suffer from EDs. Blood samples were examined in terms of blood count, glucose, cholesterol and Vitamin D3 levels. The other clinical biochemistry parameters were analysed to understand if the Vitamin D3 was the only altered parameter.

Results
The parameters that appear altered are glycemia, cholesterol and, in particular, Vitamin D3. Significant results were obtained comparing controls with restrictive-type anorexia nervosa (p value= 0,003) and with purging-type anorexia nervosa (p value= 0,007).

Conclusion
There are currently no universally validated and diagnostic reliable clinical biochemistry parameters for EDs but, in the light of the findings, but our research indicates the potential use of Vitamin D3 as a biomarker for anorexia nervosa.

Level of evidence
Level III: Evidence obtained from a single-center cohort study.
ANALISIS REALISASI PENANAMAN MODAL ASING SEBELUM DAN SAAT TERJADINYA PANDEMI COVID-19 DI JAWA TIMUR
Authors: Nadia Meria Ulva 
Published: January 2021

ABSTRACT
Foreign investment in east java province has increased from 2011 to 2013. In 2011, foreign investment amounted to US$ 1312 million, in 2012 it was US$ 2298,9 million. Meanwhile, for 2013 it reached US$ 3396,3 million. However, when Indonesia was hit by the Covid-19 pandemic which had a negative impact on the Indonesian economy and various other sectors. So this study aims to analyze the differences in the realization of foreign investment before and during the Covid-19 pandemic in East Java. The population and sample in this study are the realization of foreign investment. The sample is the realization of foreign investment in East Java. The data used is secondary data obtained from the investment coordinating board. The statistical test used to test the hypothesis is paired sample t-test. The results of this study are that there are differences in the realization of foreign investment before and during the Covid-19 pandemic in East Java. Despite the Covid-19 pandemic in Indonesia, the realization of foreign investment in East Java has increased compared to before the Covid-19 pandemic, namely in the first to third quarters of 2019.
Keywords: Covid-19 event study, investment, foreign investment.
Legal regulation of the protection of paleontological objects: the Canadian experience
Authors: Belolyubskaya Galina Stepanovna 
Published: January 2021

The protection of paleontological material occupies one of the central places in the field of preservation of objects of historical and cultural heritage. Each country has its own legal traditions and system for the protection of fossil sites on its territory. In this article, attention is paid to the legislative regulation of the search, collection and collecting of paleontological objects in Canada. The experience of this country is of particular interest for Russian practice. Unlike other countries, Russia and Canada are united by the similarity of climate, geography and natural conditions, the presence of permafrost and deposits with fossils. Therefore, the Canadian experience in the protection of paleontological objects deserves separate consideration. В Based on the analysis of the legislative acts of the provinces and territories of Canada, the article examines the features of legal regulation in this area and the organization of the state system for the protection of fossil remains. The novelty of the work lies in the fact that the focus of the study is on the formation and distribution of ownership rights to fossil objects and fossils. This allowed us to come to the following conclusions: all fossil objects, as a cultural and historical value, are owned by provinces and territories, which prevents their transformation into a commodity unit; the organization of the protection of paleontological objects has a horizontal structure, where the priority is not federal authorities, but provincial and territorial.
Traditional culture as the main marker of the ethnic identity of the Arctic peoples (on the example of the Anabar national (Dolgan-Evenki) ulus of the Republic of Sakha (Yakutia))
Authors: Mestnikova Akulina E. 
Published: January 2021

The subject of this research is the content and form of preservation, transmission of traditional culture as the most important marker of the ethnic identity of the Arctic peoples. The article presents the results of field research conducted in 2020 in the Anabar National (Dolgan-Evenki) ulus of the Republic of Sakha (Yakutia), including in the village of Yuryung-Khaya, which is the only place of compact residence of Dolgans in Yakutia. The cultural landscape of this region, including the ethno- and linguistic cultures of Dolgans, Evenks, Evens, Nganasans, Ents, Nenets, is characterized by the mutual influence of long-term ethno-cultural contacts and their reflection in cultural traditions. В The analysis of the results of the sociological survey showed that the majority of respondents (60.2%) believe that the choice of nationality is determined by: firstly, culture and traditions, secondly, native language (26.9%), thirdly, history and territory (10.4%). Based on the results of quantitative and qualitative sociological research (questionnaires, informal interviews, psycholinguistic experiment) and based on the analysis of modern scientific research, the conclusion is made about the leading positions of culture and traditions as the most important ethnoidentifiers and the determining role of traditional economic and cultural activities in the process of ethnic self-identification of indigenous peoples.