bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aesthoecology and Its Implications for Art and Design Education: Examining the Foundations
Authors: Hall Emese , Turner Chris 
Published: December 2021

AbstractAesthoecology can be described as an ‘onto‐epistemology’ which fuses a theory of being with a theory of knowledge and deals with the affective, connected and temporal aspects of education. Where the aesthetic aspect of aesthoecology – appearance and feelings/ sensation – concerns the affective domain, the ecological aspect – spaces, places and relationships – concerns connectedness. In our title, ‘foundations’ refers both to the foundations of aesthoecology and the foundations of art and design education. We highlight the implications of aesthoecology for the art and design education of young children, as elsewhere we consider its implications for higher education. Below, we explain aesthoecology in detail; identify some of aesthoecology’s implications for art and design education; and apply these to an examination of current English early years education policy. There is much room for improvement here, thus, in the spirit of Rancière, we invite aesthoecologically informed dissensus.
Nurses' strengths use and turnover intention: The roles of job crafting and self‐efficacy
Authors: Chu Xixi , Zhang Lihua , Li Mengyi 
Published: December 2021

AbstractAimsBased on conservation of resources theory, the study aimed to investigate how nurses' strengths use affects their turnover intention and its potential mechanisms and boundary conditions.DesignThe study adopted a time‐lagged research design.MethodsThe study was conducted from October 2019 to January 2020, with a sample of 234 registered nurses in a tertiary hospital in Beijing, China. The study used bootstrapping to test the hypotheses.ResultsStrengths use had a significant negative effect on turnover intention, and job crafting completely mediated the relationship between strengths use and turnover intention. Furthermore, self‐efficacy positively moderated the direct relationship between strengths use and job crafting and the indirect relationship between strengths use and turnover intention via job crafting.ConclusionThe study is the first to examine the relationships among nurses' strengths use and turnover intention, demonstrating that the activation and accumulation of work resources through job crafting can effectively reduce nurses' turnover intention. Additionally, by emphasizing the moderating effect of self‐efficacy, the study contributes to finding a way for hospitals to enhance the effectiveness of nurses' strengths use in terms of increased job crafting and reduced turnover intention.ImpactNurse managers should help nurses identify their strengths to improve their strengths use, provide nurses with more freedom to craft their jobs and take actions to build nurses' self‐efficacy and positive expectations about their jobs.
The Legal Architecture of the Economic Responses to COVID‐19: EMU beyond the Pandemic*
Authors: Fabbrini Federico 
Published: December 2021

AbstractThis article analyses from a law and policy perspectives the measures adopted by the European Union (EU) to address the devastating economic effects of COVID‐19, assessing their implications for Europe's economic and monetary union (EMU). The article first sets the background by exploring the main features of EMU before COVID‐19. Subsequently, it examines the multiplicity of policies deployed by the EU institutions to contain the socio‐economic damages of the pandemic – including, most crucially, the EU recovery fund "Next Generation EU" – and underlines their transformative effect on the EU architecture of economic governance. As the article argues, the responses to COVID‐19 have produced a significant rebalancing of EMU, bridging the asymmetry between EU monetary and economic policy. Finally, the article considers whether the COVID‐19‐related responses are likely to be only temporary, or rather a new normal for EMU, and sheds light on further constitutional adaptations which are needed to sustain this unprecedented transfer of fiscal power to the EU level.
An Introduction: “Macroeconomic Policy Coordination and Domestic Politics: Policy Coordination in the EU from the European Semester to the Covid‐19 Crisis”*
Authors: D'Erman Valerie , Verdun Amy 
Published: December 2021

AbstractThe Next Generation EU (NGEU) and the Recovery and Resilience Facility (RRF) encompassed the European Semester. To understand how and why this happened we apply different theoretical approaches so as to emphasize different aspects of this process. The contributions in this collection discuss three main questions: (1) Is the Semester successfully implemented in the domestic arena? (2) Do domestic institutions and stakeholders play a crucial role in the success (or lack thereof) of the Semester? (3) What lessons can we learn from past economic policy coordination for the challenges ahead? In answering these questions, one's lens needs to be focused at both the EU and the domestic levels. Various factors play a role: solidarity, mutual understanding, relations between the ‘South’ and the ‘North’, questions about democracy, the rule of law, the interaction between economic and social issues, and even the need to address the climate crisis (the Green Deal).
Non‐coding RNAs underlying the pathophysiological links between type 2 diabetes and pancreatic cancer: A systematic review
Authors: Dehghanian Fariba , Azhir Zahra , Khalilian Sheyda , Grüning Björn 
Published: December 2021

ABSTRACTType 2 diabetes is known as a risk factor for pancreatic cancer (PC). Various genetic and environmental factors cause both these global chronic diseases. The mechanisms that define their relationships are complex and poorly understood. Recent studies have implicated that metabolic abnormalities, including hyperglycemia and hyperinsulinemia, could lead to cell damage responses, cell transformation, and increased cancer risk. Hence, these kinds of abnormalities following molecular events could be essential to develop our understanding of this complicated link. Among different molecular events, focusing on shared signaling pathways including metabolic (PI3K/Akt/mTOR) and mitogenic (MAPK) pathways in addition to regulatory mechanisms of gene expression such as those involved in non‐coding RNAs (miRNAs, circRNAs, and lncRNAs) could be considered as powerful tools to describe this association. A better understanding of the molecular mechanisms involved in the development of type 2 diabetes and pancreatic cancer would help us to find a new research area for developing therapeutic and preventive strategies. For this purpose, in this review, we focused on the shared molecular events resulting in type 2 diabetes and pancreatic cancer. First, a comprehensive literature review was performed to determine similar molecular pathways and non‐coding RNAs; then, the final results were discussed in more detail.
Association between fat mass index, fat‐free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community‐based Cohort Study
Authors: Takase Masato , Nakamura Tomohiro , Hirata Takumi , Tsuchiya Naho , Kogure Mana , Itabashi Fumi , Nakaya Naoki , Hamanaka Yohei , Sugawara Junichi , Suzuki Kichiya , Fuse Nobuo , Uruno Akira , Kodama Eiichi N , Kuriyama Shinichi , Tsuji Ichiro , Kure Shigeo , Hozawa Atsushi 
Published: December 2021

AbstractAims/IntroductionFat mass and fat‐free mass affect glycated hemoglobin A1c (HbA1c) levels and blood glucose levels, respectively. The aim of the present study was to examine the association between the fat mass index and fat‐free mass index with HbA1c.Materials and MethodsWe carried out a cross‐sectional study that included 3,731 men and 9,191 women aged ≥20 years, living in Miyagi Prefecture, Japan, who were not treated for diabetes. The fat mass index and fat‐free mass index were calculated as fat mass and fat‐free mass divided by the height squared, respectively. The indices were classified into sex‐specific quartiles and combined into 16 groups. An analysis of covariance was used to assess associations between the combined fat mass index and fat‐free mass index with HbA1c adjusted for potential confounders. The linear trend test was carried out by stratifying the fat mass index and fat‐free mass index, entering the number as a continuous term in the regression model.ResultsIn multivariable models, a higher fat mass index was related to higher HbA1c levels in men and women in all fat‐free mass index subgroups (P < 0.001 for linear trend). When we excluded the participants who had been identified as having diabetes, the fat‐free mass index was also related to higher HbA1c levels in most fat mass index subgroups (P < 0.05 for linear trend).ConclusionsFat mass index was positively related to HbA1c levels. The fat‐free mass index was also related to HbA1c levels when we excluded participants who had been identified as having have diabetes.
Colonoscopy utilization and outcomes in older adults: Data from the New Hampshire Colonoscopy Registry
Authors: Calderwood Audrey H. , Tosteson Tor D. , Walter Louise C. , Hua Peiying , Onega Tracy 
Published: December 2021

AbstractBackgroundColonoscopy is frequently performed in older adults, yet data on current use, and clinical outcomes of and follow‐up recommendations after colonoscopy in older adults are lacking.MethodsThis was an observational study using the New Hampshire Colonoscopy Registry of adults age ≥65 years undergoing colonoscopy for screening, surveillance of prior polyps, or evaluation of symptoms. The main outcomes were clinical findings of polyps and colorectal cancer and recommendations for future colonoscopy by age.ResultsBetween 2009 and 2019, there were 42,611 colonoscopies, of which 17,527 (41%) were screening, 19,025 (45%) surveillance, and 6059 (14%) for the evaluation of symptoms. Mean age was 71.1 years (SD 5.0), and 49.3% were male. The finding of colorectal cancer was rare (0.71%), with the highest incidence among diagnostic examinations (2.4%). The incidence of advanced polyps increased with patient age from 65–69 to ≥85 years for screening (7.1% to 13.6%; p = 0.05) and surveillance (9.4% to 12.0%; p < 0.001). Recommendations for future colonoscopy decreased with age and varied by findings at current colonoscopy. In patients without any significant findings, 85% aged 70–74 years, 61.9% aged 75–79 years, 39.1% aged 80–84 years, and 27.4% aged ≥85 years (p < 0.001) were told to continue colonoscopy. Among patients with advanced polyps, 97.2% aged 70–74 years, 89.6% aged 75–79 years, 78.4% aged 80–84 years, and 66.7% aged ≥85 years were told to continue colonoscopy (p < 0.001).ConclusionsWithin this comprehensive statewide registry, clinical findings during colonoscopy varied by indication and increased with age. Overall rates of finding advanced polyps and colorectal cancer are low. Older adults are frequently recommended to continue colonoscopy despite advanced age and insignificant clinical findings on current examination. These data inform the potential benefits of ongoing colonoscopy, which must be weighed with the low but known potential immediate and long‐term harms of colonoscopy, including cost, psychological distress, and long lag time to benefit exceeding life expectancy.
Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1‐mediated DNA damage response, and antagonizing global DNA hypermethylation
Authors: Wang Qianqian , La Yumei , Xia Huihui , Zhou Shaoxia , Zhai Zhaoyu , La Honggui 
Published: December 2021

AbstractArabidopsis methylation elevated mutant 1 (mem1) mutants have elevated levels of global DNA methylation. In this study, such mutant alleles showed increased sensitivity to methyl methanesulfonate (MMS). In mem1 mutants, an assortment of genes engaged in DNA damage response (DDR), especially DNA‐repair‐associated genes, were largely upregulated without MMS treatment, suggestive of activation of the DDR pathway in them. Following MMS treatment, expression levels of multiple DNA‐repair‐associated genes in mem1 mutants were generally lower than in Col‐0 plants, which accounted for the MMS‐sensitive phenotype of the mem1 mutants. A group of DNA methylation pathway genes were upregulated in mem1 mutants under non‐MMS‐treated conditions, causing elevated global DNA methylation, especially in RNA‐directed DNA methylation (RdDM)‐targeted regions. Moreover, MEM1 seemed to help ATAXIA‐TELANGIECTASIA MUTATED (ATM) and/or SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) to fully activate/suppress transcription of a subset of genes regulated simultaneously by MEM1 and ATM and/or SOG1, because expression of such genes decreased/increased consistently in mem1 and atm and/or sog1 mutants, but the decreases/increases in the mem1 mutants were not as dramatic as in the atm and/or sog1 mutants. Thus, our studies reveals roles of MEM1 in safeguarding genome, and interrelationships among DNA damage, activation of DDR, DNA methylation/demethylation, and DNA repair.
Spontaneous disseminated T‐cell lymphoma in a buff‐headed capuchin (Sapajus xanthosternos)
Authors: Pereira Asheley Henrique Barbosa , Maruyama Fernanda Harumi , Dutra Valéria , Moreira Silvia Bahadian , Pissinatti Alcides , Ubiali Daniel Guimarães 
Published: December 2021

AbstractReports of spontaneous hematopoietic neoplasms in Platyrrhines species are scarce. We present the gross, histological, and immunohistochemical findings of disseminated T‐cell lymphoma in a male 25‐year‐old Sapajus xanthosternos kept in a Brazilian conservation center. No molecular evidence of betaherpesvirus or gammaherpesvirus was associated with the occurrence of this neoplasm.
Mitigating the detrimental effect of skeuomorphism on gambling behavior
Authors: Meng Matthew D. , Leary R. Bret 
Published: December 2021

AbstractSkeuomorphism is a design style that retains superfluous aspects in modern designs. A strong proponent of skeuomorphism is the gambling industry, with many digital games appearing similar to physical games (e.g., barrels “spinning” on digital slot machines), even though these elements serve no functional purpose. Despite the extensive use of skeuomorphs in modern gambling interfaces, little research has examined their link to gambling behavior and, in particular, their potential negative effects on well‐being. Through three studies, the current research finds evidence that skeuomorphic design elements (vs. flat design) can increase amount gambled in games of pure chance, an effect that is moderated by locus of control (i.e., internals show a greater effect). Further, highlighting the uncontrollability of skeuomorphic games significantly reduces intended amount bet, thus impacting well‐being. Implications of these findings for consumers, advocacy groups, policy makers, and marketers are discussed.
Bank compliance with national transaction account standards: Evidence from a mid‐western metropolitan area
Authors: Birkenmaier Julie , Huang Jin , Balu Alana 
Published: December 2021

AbstractIncreasing the fully banked population is related to the availability of affordable bank accounts. This study investigates the factors that are associated with bank response to voluntary national bank account standards for an affordable transaction account. We also examine the degree to which account information is available from bank websites. Account feature data were collected from public bank websites and bank tellers (N = 108) in a mid‐western metropolitan area. Results suggest that most banks offer an account that meets the majority of the standards. On average, bank websites are missing information about eight (44%) of the voluntary standards. There is weak evidence to suggest that bank asset size is associated both with the number of standards met and the numbers of standards about which a viewer cannot assess from information on their website. Practice and policy implications of the voluntary standards on the availability of affordable transaction accounts are discussed.
Cushing's syndrome caused by intra‐adrenocortical adrenocorticotropic hormone in a dog
Authors: Soler Arias Elber A. , Castillo Víctor A. , Louiset Estelle , Lefebvre Herve 
Published: December 2021

AbstractA 13‐year‐old Labrador retriever was diagnosed with Cushing's syndrome (CS) caused by primary bilateral nodular adrenocortical hyperplasia with adrenocorticotropic hormone (ACTH) expression. The pituitary origin of CS was ruled out by suppression of plasma ACTH concentration and absence of a proliferative lesion on histological evaluation of the pituitary gland using periodic acid‐Schiff (PAS) staining, reticulin staining, and immunostaining for ACTH. A pheochromocytoma also was found at necropsy examination. On histological evaluation of both adrenal glands, at the junction of the fascicular and glomerular zones, multiple cell clusters distributed in both hyperplastic adrenal cortices expressed ACTH, whereas the pheochromocytoma cells did not. These results indicate that a disease similar to primary bilateral macronodular adrenocortical hyperplasia in humans also occurs in dogs, with intra‐adrenocortical expression of ACTH, glucocorticoids excess, and clinical signs of CS. Therefore, the term ACTH‐independent could be inappropriate in some cases of bilateral adrenocortical hyperplasia and suppressed plasma ACTH concentration in dogs.
Longitudinal, 5‐year long‐term outcomes for urinary continence and quality of life after robot‐assisted radical prostatectomy in Japanese patients
Authors: Hikita Katsuya , Honda Masashi , Shimizu Ryutaro , Teraoka Shogo , Kawamoto Bunya , Yumioka Tetsuya , Tsounapi Panagiota , Iwamoto Hideto , Morizane Shuichi , Takenaka Atsushi 
Published: December 2021

AbstractObjectivesThe aim of this study was to investigate the longitudinal 5‐year long‐term outcomes for urinary continence and quality of life (QOL) after robot‐assisted radical prostatectomy (RARP), particularly nerve‐sparing.MethodsAmong patients who underwent RARP between October 2010 and October 2015, postoperative urinary symptoms were retrospectively examined using the International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire‐Short Form (ICIQ‐SF), QOL index, and number of pads used. Patients were divided into nerve‐sparing and non‐nerve‐sparing groups, and all data were evaluated before and at 1, 3, 6, 12, 24, 36, 48, and 60 months after surgery.ResultsAfter propensity score matching, 47 patients each were included in the two groups. No significant difference in the IPSS or QOL index was seen between groups. The IPSS and QOL index showed an increase in the first month after RARP, but at 6 months, values were lower than preoperative levels and then slowly improved. Pad‐free rates at 5 years after surgery were 93.6% and 80.1% in the nerve‐sparing and non‐nerve‐sparing groups, respectively (P = .029). ICIQ‐SF scores were significantly improved in the nerve‐sparing compared with the non‐nerve‐sparing group at 1, 3, and 6 months after surgery. After 12 months, no significant changes were identified until 60 months.ConclusionsIn this study, nerve‐sparing had a strong impact on urinary continence in the early postoperative period. After 12 months, urinary continence remained stable until 60 months.
Optimal fund menus
Authors: Cvitanić Jakša , Hugonnier Julien 
Published: December 2021

AbstractWe study the optimal design of a menu of funds by a manager who is required to use linear pricing and does not observe the beliefs of investors regarding one of the risky assets. The optimal menu involves bundling of assets and can be constructed from the solution to a calculus of variations problem that optimizes over the indirect utility that each type receives. We provide a complete characterization of the optimal menu and show that the need to maintain incentive compatibility leads the manager to offer funds that are inefficiently tilted towards the asset that is not subject to the information friction.
Searching for “the usual suspects”: The role of discretion and target group constructions in the frontline of policy implementation
Authors: Nørup Iben , Jacobsen Betina 
Published: December 2021

AbstractThis study investigates the implementation of preventive policy targeting children. Based on longitudinal survey data we analyze how frontline workers assign meaning to core concepts of the policy and categorize the children and in this light how their exercise of discretion affects policy implementation. Many studies problematize the effects of limiting the discretion in the frontline. We identify a case where the policy is highly ambiguous, the definitions of target groups, core concepts, or central goals are vague, and the general steering of the frontline is not characterized by a lack of discretion but a lack of organizational boundaries to shape the discretion. This expands not only the policymaking role of the frontline but also becomes a barrier to developing a stronger preventive effort. The findings give nuanced insight into how organizational boundaries affect the discretion and target group construction in the frontline during frontline implementation of welfare policies.
Challenges with pediatric anesthesia and intraoperative ventilation of the child in the resource‐constrained setting
Authors: Ndikontar Kwinji Raymond , Evans Faye , Gray Rebecca M. 
Published: December 2021

AbstractThe systemic challenges in providing safe anesthesia, including safe ventilation, to children in resource‐constrained settings are many. For anesthesia providers caring for children, the lack of appropriate equipment, inadequate anesthesia workforce and deficiencies in postoperative care are especially difficult. The clinical decisions made by anesthesia providers around when and how to ventilate a child for surgery are influenced by all of these factors and can result in patient management which may vary significantly from that in a high‐resource setting. This educational review considers the intraoperative ventilation of a small child in a resource‐constrained setting and discusses specific challenges and context‐sensitive solutions.
Ratiometric Fluorescent Sensor for Copper(II) and Phosphate Ions from Aminopyrene Derivatives
Authors: Asavasuthiphan Voravin , Nuisin Roongkan , Kraiya Charoenkwan , Sukwattanasinitt Mongkol , Rashatasakhon Paitoon 
Published: December 2021

ABSTRACTThree derivatives of 1‐aminopyrene are functionalized with 2‐picolyl and 2‐picolinyl groups and are tested as fluorescent sensors for metal ions. The target compounds are successfully synthesized in yields of 50–90% and characterized by 1H‐NMR, 13C‐NMR, and HRMS. The compound with an amino picolyl group (P1) exhibits an excellent selectivity toward Cu(II) ion as the fluorescent signal shifts from 433 to 630 nm. From a fluorescence titration experiment, the limit of detection for Cu(II) ion is estimated as 0.19 µm. The fluorescence spectral shift by Cu(II) ion is reliant on the use of acetonitrile as a co‐solvent, and the results from cyclic voltammetry and UV‐Vis spectroscopy suggest that the sensing mechanism involves a coordination complex between the P1, acetonitrile and Cu(II) ion. Furthermore, this P1‐Cu complex can also be used as a selective fluorescent sensor for PO43− ion with a detection limit of 0.44 µm.