bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptotic behavior of Newton-like inertial dynamics involving the sum of potential and nonpotential terms
Authors: Adly Samir , Attouch Hedy , Vo Van Nam 
Published: October 2021

AbstractIn a Hilbert space $\mathcal{H}$
H
, we study a dynamic inertial Newton method which aims to solve additively structured monotone equations involving the sum of potential and nonpotential terms. Precisely, we are looking for the zeros of an operator $A= \nabla f +B $
A
=
∇
f
+
B
, where ∇f is the gradient of a continuously differentiable convex function f and B is a nonpotential monotone and cocoercive operator. Besides a viscous friction term, the dynamic involves geometric damping terms which are controlled respectively by the Hessian of the potential f and by a Newton-type correction term attached to B. Based on a fixed point argument, we show the well-posedness of the Cauchy problem. Then we show the weak convergence as $t\to +\infty $
t
→
+
∞
of the generated trajectories towards the zeros of $\nabla f +B$
∇
f
+
B
. The convergence analysis is based on the appropriate setting of the viscous and geometric damping parameters. The introduction of these geometric dampings makes it possible to control and attenuate the known oscillations for the viscous damping of inertial methods. Rewriting the second-order evolution equation as a first-order dynamical system enables us to extend the convergence analysis to nonsmooth convex potentials. These results open the door to the design of new first-order accelerated algorithms in optimization taking into account the specific properties of potential and nonpotential terms. The proofs and techniques are original and differ from the classical ones due to the presence of the nonpotential term.
Ultrasound-accelerated thrombolysis in high-risk perioperative pulmonary embolism: two case reports and review of literature
Authors: Schmidt Götz , Edinger Fabian , Koch Christian , Wolff Matthias , Biehl Christoph , Hörbelt Rüdiger , Sander Michael 
Published: October 2021

Abstract
Introduction
Treatment of high-risk pulmonary embolism (PE) in perioperative patients remains challenging. Systemic thrombolysis is associated with a high risk of major bleedings and intracranial haemorrhage. High mortality rates are reported for open pulmonary embolectomy. Therefore, postoperative surgical patients may benefit substantially from catheter-directed ultrasound-accelerated thrombolysis (USAT).

Case presentation
We report two cases of high-risk perioperative PE. Both patients developed severe haemodynamic instability leading to cardiac arrest. After the implantation of a veno-arterial extracorporeal membrane oxygenation (ECMO), they were both successfully treated with USAT. Adequate improvement of right ventricular function was achieved; thus, ECMO could be successfully weaned after 3 and 4 days, respectively. Both patients showed favourable outcomes and could be discharged to rehabilitation.

Conclusion
Current guidelines on treatment of PE offer no specific therapies for perioperative patients with high-risk PE. However, systemic thrombolysis is often excluded due to the perioperative setting and the risk of major bleeding. Catheter-directed thrombolysis was shown to utilise less thrombolytic agent while obtaining comparable thrombolytic effects. The risk for major bleeding (including intracranial haemorrhage) is also significantly lowered. Until further trials determining the value of adopted treatment strategies of high-risk PE in perioperative patients are available, USAT should be considered in similar cases.
Phenotypic intrafamilial variability including H syndrome and Rosai–Dorfman disease associated with the same c.1088G > A mutation in the SLC29A3 gene
Authors: Chouk Hamza , Ben Rejeb Mohamed , Boussofara Lobna , Elmabrouk Haїfa , Ghariani Najet , Sriha Badreddine , Saad Ali , H’Mida Dorra , Denguezli Mohamed 
Published: October 2021

Abstract
Background
Mutations in the SLC29A3 gene, which encodes the nucleoside transporter hENT3, have been implicated in syndromic forms of histiocytosis including H syndrome, pigmented hypertrichosis with insulin-dependent diabetes, Faisalabad histiocytosis and Familial Rosai–Dorfman disease (RDD). Herein, we report five new patients from a single family who present with phenotypes that associate features of H syndrome and Familial Rosai–Dorfman disease.

Methods
We investigated the clinical, biochemical, histopathological and molecular findings in five Tunisian family members' diagnosed with Familial RDD and/or H syndrome. The solute carrier family 29 (nucleoside transporters), member 3 (SLC29A3) gene was screened for molecular diagnosis using direct Sanger sequencing.

Results
Genetic analysis of all affected individuals revealed a previously reported missense mutation c.1088 G > A [p.Arg363Gln] in exon 6 of the SLC29A3 gene. Four affected members presented with clinical features consistent with the classical H syndrome phenotype. While their cousin’s features were in keeping with Familial Rosai–Dorfman disease diagnosis with a previously undescribed cutaneous RDD presenting as erythematous nodular plaques on the face. This report underlines the clinical variability of SLC29A3 disorders even with an identical mutation in the same family.

Conclusion
We report a rare event of 5 Tunisian family members' found to be homozygous for SLC29A3 gene mutations but showing a different phenotype severity. Our study reveals that despite a single mutation, the clinical expression of the SLC29A3 disorders may be significantly heterogeneous suggesting a poor genotype–phenotype correlation for the disease.
Expression of circulating cell-free nucleic acids around miniscrew implant during orthodontic tooth movement—a prospective study
Authors: Qureshi Tabassum , Duggal Ritu , Kharbanda Om Prakash , Rajeswari Moganty R. 
Published: October 2021

Abstract
Objectives
Literature shows that the expression of various biomarkers in peri-miniscrew crevicular fluid (PMICF) is related to the stability of miniscrew implants (MSIs). The present study investigated the role and alterations in levels of circulating cell-free nucleic acids (cfNAs) in PMICF before and after orthodontic loading.

Material and methods
This prospective study consisted of forty-six MSIs placed between the second premolar and first molar in the maxillary and mandibular arches. Direct loading was done after 3 weeks of MSI insertion with nickel-titanium closed coil spring exerting a force of 200 g. The PMICF sample was collected at various time intervals, and the level of cfNA was determined. Clinical parameters, including implant mobility and gingival health, were also assessed. Pre-loading and post-loading parameters were assessed using Wilcoxon’s rank-sum test.

Results
Among 46 MSIs, 36 were stable during the study and 10 MSIs showed peri-implant inflammation and increased mobility. There was a significant rise in the cfNA concentration 24 h after implant insertion (0.4 ± 0.86 ng/μl). The level of cfNAs significantly decreased over 3 weeks and reached the baseline level (0.2 ± 0.31 ng/μl). There was also a significant rise in the levels of cfNA (0.8 ± 0.70 ng/μl) at 24 h after loading MSIs, which gradually decreased to 0.2 ± 0.24 ng/μl after 63 days. The expression of cfNAs was on the average 0.32 units more in the cases with failed implants (P = 0.05).

Conclusions
cfNA levels in PMICF showed an upward trend 24 h after MSI insertion and 24 h after orthodontic loading. The expression of cfNA was more in cases with failed MSIs. Hence, the cfNAs can be considered as a prognostic biomarker of MSI stability.
Comparison of zirconia degradation in dental implants and femoral balls: an X-ray diffraction and nanoindentation study
Authors: Gil Javier , Delgado-García-Menocal José Angel , Velasco-Ortega Eugenio , Bosch Begoña , Delgado Luis , Pérez-Antoñanzas Román , Fernández-Fairén Mariano 
Published: October 2021

Abstract
Background
New tetragonal zirconia polycrystal dental implants stabilized with yttria (Y-TZP) have appeared in the implantology market in the form of single piece or two-piece zircona implant system. These new type of implants improve the aesthetical properties compared to conventional commercially pure (c.p.) titanium used for implants, although the long term mechanical behavior of these new implants is not yet well known. In orthopaedics, the application of zirconia as femoral balls presented an important controversial use due to the premature fracture once implanted. Y-TZP dental implants can be affected by hydrothermal degradation and its behavior should be analysed to avoid a premature fracture. The scientific question behind the study is to analyse if the degradation mechanism observed in orthopaedics applications of Y-TZP is similar to that of Y-TZP for dental applications.

Materials and methods
For this purpose, 30 original Y-TZP dental implants and 42 Y-TZP femoral balls fractured in vivo have been studied. Dental implants were submitted to an accelerated hydrothermal degradation to compare with the femoral balls fractured in vivo. Phase transformation as well as the mechanical behaviour of the degraded samples was studied by X ray diffraction and nanoindentation tests, respectively.

Results
Results have shown that the fracture mechanism of dental implants does not resemble the mechanism observed in orthopaedic samples, presenting a good long-term behaviour.

Conclusion
The results ensure the good performance of zirconia dental implants, because the degradation of the ceramic is very limited and does not affect the mechanical properties.
Noise suppression using a near-source wavelet
Authors: Aghayan Afshin , Jaiswal Priyank 
Published: October 2021

Denoising becomes a nontrivial task when the noise and signal overlap in multiple domains, such as time, frequency, and velocity. Fortunately, signal and noise waveforms, in general, tend to remain morphologically different and such differences can be used to separate body-wave signals from other waveforms such as ground roll and cultural noise. The key in denoising using a near-source wavelet is to find a wavelet that is a close approximation of the true source signature and remains uncontaminated by the Green’s function in any significant manner. An inverse filter designed using such a wavelet selectively compresses the body waves that can be extracted using median and low-pass filters. The overall phenomenon is explained with a synthetic example. The idea is also tested on a land data set generated using a large weight-drop source in which the wavelet recorded approximately 3 m from the source location fulfills the criteria set in our method. The results suggest that the incremental effort of recording an extra trace close to the source location during acquisition may provide previously unavailable denoising opportunities during processing, although the trace itself may be redundant for imaging.
Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia
Authors: Linglart Agnès , Imel Erik A , Whyte Michael P , Portale Anthony A , Högler Wolfgang , Boot Annemieke M , Padidela Raja , van’t Hoff William , Gottesman Gary S , Chen Angel , Skrinar Alison , Scott Roberts Mary , Carpenter Thomas O 
Published: October 2021

Abstract

Purpose
In X-linked hypophosphatemia (XLH), excess fibroblast growth factor-23 causes hypophosphatemia and low calcitriol, leading to musculoskeletal disease with clinical consequences. XLH treatment options include conventional oral phosphate with active vitamin D, or monotherapy with burosumab, a monoclonal antibody approved to treat children and adults with XLH. We have previously reported outcomes up to 64 weeks, and here we report safety and efficacy follow-up results up to 160 weeks from an open-label, multicenter, randomized, dose-finding trial of burosumab for 5- to 12-year-old children with XLH.

Methods
After 1 week of conventional therapy washout, patients were randomized 1:1 to burosumab every 2 weeks (Q2W) or every 4 weeks (Q4W) for 64 weeks, with dosing titrated based on fasting serum phosphorus levels between baseline and week 16. From week 66 to week 160, all patients received Q2W burosumab.

Results
Twenty-six children were randomized initially into each Q2W and Q4W group and all completed treatment to week 160. In 41 children with open distal femoral and proximal tibial growth plates (from both treatment groups), total Rickets Severity Score significantly decreased by 0.9 ± 0.1 (least squares mean ± SE; P &lt; 0.0001) from baseline to week 160. Fasting serum phosphorus increases were sustained by burosumab therapy throughout the study, with an overall population mean (SD) of 3.35 (0.39) mg/dL, within the pediatric normal range (3.2-6.1 mg/dL) at week 160 (mean change from baseline P &lt; 0.0001). Most adverse events were mild to moderate in severity.

Main conclusions
In children with XLH, burosumab administration for 160 weeks improved phosphate homeostasis and rickets and was well-tolerated. Long-term safety was consistent with the reported safety profile of burosumab.

Clinicaltrials.gov
NCT02163577
Fetal and Neonatal Thyroid Dysfunction
Authors: Léger Juliane , Delcour Clemence , Carel Jean-Claude 
Published: October 2021

Abstract
Fetal and neonatal dysfunctions include rare serious disorders involving abnormal thyroid function during the second half of gestation, which may persist throughout life, as for most congenital thyroid disorders, or be transient, resolving in the first few weeks of life, as in autoimmune hyperthyroidism or hypothyroidism and some cases of congenital hypothyroidism (CH) with the thyroid gland in situ. Primary CH is diagnosed by neonatal screening, which has been implemented for 40 years in developed countries and should be introduced worldwide, as early treatment prevents irreversible neurodevelopmental delay. Central CH is a rarer entity occurring mostly in association with multiple pituitary hormone deficiencies. Other rare disorders impair the action of thyroid hormones. Neonatal Graves’ disease (GD) results from the passage of thyrotropin receptor antibodies (TRAbs) across the placenta, from mother to fetus. It may affect the fetuses and neonates of mothers with a history of current or past GD, but hyperthyroidism develops only in those with high levels of stimulatory TRAb activity. The presence of antibodies predominantly blocking thyroid-stimulating hormone receptors may result in transient hypothyroidism, possibly followed by neonatal hyperthyroidism, depending on the balance between the antibodies present. Antithyroid drugs taken by the mother cross the placenta, treating potential fetal hyperthyroidism, but they may also cause transient fetal and neonatal hypothyroidism. Early diagnosis and treatment are key to optimizing the child’s prognosis. This review focuses on the diagnosis and management of these patients during the fetal and neonatal periods. It includes the description of a case of fetal and neonatal autoimmune hyperthyroidism.
The Life Strike
Authors: Bentouhami Hourya 
Published: October 2021

Abstract
This article examines the forms of disobedience practiced by migrants at the European border to circumvent biotechnological modes of surveillance and identification, which are rooted in involuntary movements that can be used as evidence against migrants. What actually happens when bodily growth, heart rate, respiration, and body heat are integrated into technologies for the detection of life with a view to their measurement (biometrics) and the constitution of a database needed for border surveillance? What happens when life is turned against itself? How to disobey when the involuntary dimensions of the body—not only one's appearance but the body's very organicity and biochemistry—become the sites of a surveillance from which one can only escape by holding one's breath or burning one's fingerprints? This essay asks how the emerging tactics of migrants seek to escape their interior, organic lives, and identifies the “life strike” as a form of thanato-mimesis that consists in playing dead and limiting what in organic life is recognizable as such in order to go unnoticed and to interrupt racial interpellations.
Abolition Pedagogy
Authors: Gillespie Kelly , Naidoo Leigh-Ann 
Published: October 2021

Abstract
As the South African student movement of 2015–16 began to develop a deeper critique of the character of the transition out of apartheid and its minimal effect on the institutions of colonialism and apartheid, the administrators of postapartheid universities worked with the managers of the security infrastructure of the state to orchestrate a national police shutdown of the student and worker movement. This essay is an effort to sustain an objection to that coordinated effort, and to work through a proposal for how the new managers of the postapartheid state and university could have—should have—acted otherwise. This proposal is called abolition pedagogy, a refusal of the long-standing relationship between education and violence, and a reading of the pedagogic labor involved in antiviolence work. In the midst of the recent student protests, a 1969 exchange of letters between Theodor Adorno and Herbert Marcuse—in which Adorno justifies his having “called the police” on the student movement in Germany—was used to justify calling the police on South African students some fifty years later. This article unpacks the citation, and uses Adorno's own commitment to critique as a “force field” to show up the limitations of his position, and to call for a different mode of engagement with the difficulties and possibilities of ongoing struggle. Adorno's “force field” is contrasted with his poor reckoning with jazz and his inability to see the work of critique in jazz and by implication in many other forms. Abolition pedagogy pursues a transformative orientation to histories of violence, asking how to sustain strategies for their unmaking.
Acute Neuromuscular Response to Team Sports–Specific Running, Resistance, and Concurrent Training: A Crossover Study
Authors: CROSS REBECCA , LOVELL RIC , MARSHALL PAUL W. , SIEGLER JASON 
Published: October 2021

ABSTRACT

Purpose
This study aimed to examine the changes in muscle contractile function, voluntary activation, and muscle damage after lower limb resistance training (RT), intermittent sprint exercise, and concurrent training (CT).

Methods
Ten male, recreational team sport athletes with a history of RT participated in a randomized crossover study involving an intermittent sprint protocol (ISP), lower limb RT, and CT (ISP and RT separated by 1 h). Before (PRE), immediately after (POST), 24 h and 48 h after each exercise condition, quadriceps muscle activation, voluntary activation, muscle contractile function (evoked twitch responses), creatine kinase, muscle soreness, and Profile of Mood States (POMS)–fatigue were recorded.

Results
Quadriceps contractile function was hampered in all conditions, with a significantly greater decline observed POST RT (58.4% ± 18.0%) and CT (54.8% ± 8.6%) compared with ISP (35.9% ± 10.7%, P < 0.05), recovering at 48 h after all exercise conditions. POMS–fatigue ratings increased at POST in all conditions with CT and ISP eliciting the greatest increase, returning to baseline 48 h after all exercise conditions. Quadriceps muscle soreness remained elevated from PRE at 48 h after all exercise conditions. No changes across time were observed for voluntary activation and quadriceps surface EMG amplitude after any exercise condition. The volume and load lifted in the RT session was unaffected by previous intermittent exercise (ISP) in CT.

Conclusions
RT impairs contractile function, which is not exacerbated when performed 1 h after the ISP. Contractile function after all exercise conditions displayed the same recovery profile (48 h) despite the postexercise decrement being smaller after the ISP compared with RT and CT. Previous intermittent sprint exercise does not negatively affect the volume of exercise performed in a lower limb RT session.
Effects of Water Immersion on the Internal Power of Cycling
Authors: VINETTI GIOVANNI , FERRETTI GUIDO , HOSTLER DAVID 
Published: October 2021

ABSTRACT

Purpose
Water immersion adds additional drag and metabolic demand for limb movement with respect to air, but its effect on the internal metabolic power (Ė
int) of cycling is unknown. We aimed at quantifying the increase in Ė
int during underwater cycling with respect to dry conditions at different pedaling rates.

Methods
Twelve healthy subjects (four women) pedaled on a waterproof cycle ergometer in an experimental pool that was either empty (DRY) or filled with tap water at 30.8°C ± 0.6°C (WET). Four different pedal cadences (f
p) were studied (40, 50, 60, and 70 rpm) at 25, 50, 75, and 100 W. The metabolic power at steady state was measured via open circuit respirometry, and Ė
int was calculated as the metabolic power extrapolated for 0 W.

Results
The Ė
int was significantly higher in WET than in DRY at 50, 60, and 70 rpm (81 ± 31 vs 32 ± 30 W, 167 ± 35 vs 50 ± 29 W, 311 ± 51 vs 81 ± 30 W, respectively, all P < 0.0001), but not at 40 rpm (16 ± 5 vs 11 ± 17 W, P > 0.99). Ė
int increased with the third power of f
p both in WET and DRY (R
2 = 0.49 and 0.91, respectively).

Conclusions
Water drag increased Ė
int, although limbs unloading via the Archimedes’ principle and limbs shape could be potential confounding factors. A simple formula was developed to predict the increase in mechanical power in dry conditions needed to match the rate of energy expenditure during underwater cycling: 44 f
p
3 – 7 W, where f
p is expressed in Hertz.
Contribuições do kanban eletrônico e tradicional para a gerenciamento de leitos hospitalares
Authors: Silva Thainy Genny Esteves , Silva Mariane Francis Souza Bezerra da , Vieira Lara Camila Nery , Pimentel Cristiane Angra , Musetti Marcel Andreotti 
Published: October 2021

A falta de leitos resulta em filas de espera e em pacientes em corredores esperando em macas aguardando por leitos. Estes desafios geram a insatisfação nos pacientes e nos profissionais da saúde e podendo causar o aumento de gasto da organização, por conta do tempo elevado de permanência em internações e má gerenciamento dos recursos. O uso do gerenciamento de leito e de conceitos e ferramentas da filosofia Lean Healthcare, como o Kanban que permite melhor controle das demandas e auxilia no aumento da taxa de ocupação das instituições, maior utilização da capacidade disponível, tendo efeito direto no aumento da satisfação dos pacientes. Este artigo pretende apresentar as diferentes características do Kanban tradicional e eletrônico para a gerenciamento de leitos. A metodologia empregada foi a pesquisa exploratória e bibliográfica. Foram utilizados mecanismos de busca como Google Scholar, Web of Science e Scopus, conforme as palavras-chave: lean healthcare, kanban, kanban eletrônico, gerenciamento de leitos, entre outros termos relacionados para uma ampla busca sobre o conteúdo. Com a análise realizada os resultados encontrados foram as contribuições geradas da utilização da ferramenta Kanban eletrônico, que proporciona uma otimização no gerenciamento de leitos através da eficiência no acesso e atualização de dados, aumentando a autonomia dos agentes de saúde e oferecendo atendimentos com qualidade para os pacientes. O estudo contribui para a sociedade acadêmica fornecendo um panorama da utilização da ferramenta Kanban em unidades hospitalares para o gerenciamento de leitos.